RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Publish Subscribe Internet Technology'.

assistant: **Objectives**

The current Internet architecture focuses on communicating entities, leaving aside the exchanged information. However, trends show that WHAT is exchanged is becoming more important than WHO are exchanging it. As a result, the Internet is effectively moving from interconnecting machines to interconnecting information, questioning the necessity of endpoint identifiers as a foundation of internetworking.<br/>There have been efforts to introduce identifiers for information rather than endpoints on internetworking level, e.g., the FP7 PSIRP and the PARC CCN project, the former based on an information-centric publish/subscribe model and the latter based on a content-centric overlay. These efforts promise, among other things, more flexibility in adapting to new services, efficiency improvements on lower layers, and native multicast support.<br/>However, crucial questions remain, like (1) the role of caching, potentially leading to new concepts for congestion and error control, (2) the role of transport functions, (3) service-specific delivery solutions, and (4) support for disconnected operations. There are also open questions regarding the influence on lower layer operations, including resource allocation and reservation, resulting from the increased visibility of the exchanged information. Also, efficient re-allocation of optical resources and bundling of wireless resources need to be studied to gain insight into how such novel architecture can efficiently work with lower layers. Last, but not least, the socio-economic environment needs to be understood. The markets being created as well as the impact of socio-economics on design choices are as important as outlining the opportunities and threats for existing and new players to come. Demonstrating and validating practical so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Stability of sorbed arsenic by pipe scales and biofilms in drinking water distribution systems'.

assistant: **Concept**

The notion that inorganic contaminants behave conservatively between the point of entry (after conventional or reverse osmosis-desalination water treatment) and the point of use by consumers is currently being re-visited by EU regulatory agencies. One of the main reasons deteriorating the quality of home tap water is related to the accumulation of contaminants, such as arsenic (As) to scale and biofilm growth in drinking water pipe walls. The central hypothesis of the proposed research is that changes in solution chemistry of the finished water adversely influences the stability of sorbed As by pipe scales. Our long-range goal is to provide mechanistic insight to critical unanswered questions related to the stability of sorbed As by pipe scales and biofilm conglomerates (PSBC) in drinking water distribution systems, thereby eliminating health risk associated with human ingestion of As-contaminated water. If we identify the factors influencing the stability of sorbed As, then we could formulate guidelines to minimize the health risk from the release of sorbed As into the finished water. The stability of the pipe scales (amorphous masses of corrosion by-products mixed with biofilms) may be undermined by the presence of disinfection by-products, ii) to the nonconventional corrosivity of desalinated water or iii) by changes in bulk solution chemical properties and SBC surface chemical parameters. Knowledge obtained from this project will, i) minimize the human health risk associated with the presence of toxic As in the finished water; and ii) formulate specific guidelines for the effective decontamination of SBC in drinking water pipes. This IRG project will prove most useful to the recently reintegrated coordinator towards developing his Water and Health research program i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'West africa's savannah under change. sensitivity of the savannah in west africa to population change, cultivation change and climate change' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

WASAC is aiming at providing a common platform for understanding the stability of savannah region soils in relation to soil organic matter and emissions, nutrients and plant growth, different management types and the need for increased food production. This knowledge is essential for identifying the net carbon balance in terms of the Kyoto protocol.In the project:- existing data on carbon and gas emissions will be identified and collated;- different plant covers will be considered as management options;- effects of fertilizers and fires will be integrated with the vegetation concept;- a data base will be established for savannah carbon and nitrogen data;- a synthesis volume on soil carbon and gas emission will be produced;- guidelines on sustainable management will be elaborated by topic groups;- in two languages. The project is directly based on experience from bilateral cooperation and a EU contract.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ADVANCED TRACER SIMULATION MODULE TO IMPROVE OIL RECOVERY' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The software to be validated is the ITCR (IFE Tracer Reseasch Cooperation) module for modelling tracer flow in reservoirs. Tracers play an important role in mapping fluid flow and remaining oil and gas saturation. In this respect, it is crucial to possess a reliable modelling tool predicting tracer response curves, especially in the case of the recently developed partioning tracers. The project aims to validate and demonstrate the superiority (over conventional tracer options in standard commercial simulators) of the ITRC tracer module for use in field scale reservoir tracer simulation projects. In particular, the field cases to be studied for testing and validation of its performance should result in improved reservoir description and flow pattern of the Gullfaks field and a better description of the efficiency of the WAG pilot process in the Snorre field. The capabilities of the module will be demonstrated by coupling it to black oil (Eclipse) and Compositional (CMG) simulators.L%The field tracer data and core samples have been at the forefront of experimental and computational techniques for the structural and flow properties characterisation of a variety of porous materials (from micro- to macro-pores). Participation to collaborative projects (BRITE-EURAM, JOULE) has contributed to the development of expertise and the acquisition of modern characterisation facilities.Assuming that tracers do not affect the flow of other fluids in the reservoir, the calculation of tracer flow may be performed in a module separated from the rest of the reservoir simulator. At each timestep of the reservoir simulator, the tracer module needs flow parameters such as grid block pressures, phase velocities and saturations to be transferred from the host simulator. The advantage of such an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Use of genomic and proteomic tools for the development of contaminant specific biomarkers for the environmental risk assessment of aquatic ecosystems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The use of genomic tools is rapidly increasing in ecotoxicology, and results from transcriptomic and proteomic studies of the effects of environmental pollutants are becoming more and more available. Apart from the knowledge of the mechanisms involved in toxic processes, the aim of conducting research on genomic and proteomic level is the development of contaminant specific biomarkers for the risk assessment of aquatic ecosystems able to respond at environmentally relevant low contaminant concentrations. However, even if important information is gathered on differential gene and proteome expression, the development of contaminant specific biomarkers in model organisms is still a task to be tackled. In this context, an attempt to joint efforts for the discovery and development of susceptible genes and proteins to be employed in routine environmental risk assessment is highly desirable. Several marine species from different organizational and trophic levels (the marine microalgae, Phaeodactylum tricornutum, and Cylindritheca closterium; the copepods Tisbe battagliai, Tigriopus japonicus, and Nitokra spinipes; the estuarine amphipod Melita plumulosa; the clam, Ruditapes decussates and the cockle Cerastoderma glaucum; the mussel Mytilus galloprovincialis; the oysters Crassostrea brasiliana, Crassostrea gigas and Crassostrea rhizophora; and the guppy, Poecilia vivipara) will be tested for the genomic and proteomic effects of the exposure to priority contaminants and the responses analyzed for similarities at different organizational levels with the aim to develop interspecies relevant biomarkers for environmental risk assessment of the most important contaminants, while at the same time transferring knowledge and experience by providing excellent training in cutting edge tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unveiling the tripartite dynamics between satellites, helper phages and bacteria'.

assistant: **Innovation**

Phages, viruses that infect bacteria, play key roles in shaping bacterial fitness and evolution. At the same time, phages themselves are parasitized by satellites - mobile genetic elements (MGEs) lacking genes for autonomous replication but that can hijack (helper) phages for their own propagation. Despite billions of years of coevolution between satellites, phages and bacteria, we know little about how selection affects these elements and their interactions. Recent studies showed that P4-like satellites are diverse and widespread across distant bacterial genomes, but outside a few P2-like prophages described decades ago, the actual range of phages that P4-like elements can hijack is unknown. The aim of my project is to decipher the mobilization potential of P4-like satellites, study the genetic basis of this mobilization and reveal how selection acts on satellites, phages and bacteria when they coevolve. With access to over 200 strains of Escherichia coli and Klebsiella, I will combine experimental and computational analyses to shed light on the genetic and evolutionary interactions between P4-like satellites, their helpers and their common bacterial hosts. Leveraging my expertise in microbial evolution and molecular biology, this project will introduce new expertise in satellite biology, bioinformatics, and coevolutionary microbiology. This project will provide new models to explore satellite-helper dynamics, with potential applications in biotechnology and phage therapy. At the Institut Pasteur, I will collaborate in an interdisciplinary environment within the Department of Genomes and Genetics, receiving outstanding academic training with numerous opportunities for interdisciplinary collaborations. This provides unique prospects for my career development towards ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Modeling and Design of Thin Film Waveguides Terminated with Nano-optical Transducers'.

assistant: **Objectives**

Nano-optics is a rapidly growing field with potential uses in many practical applications. Near-field optical techniques that enhance localized surface plasmons are potential candidates for obtaining intense optical spots beyond the diffraction limit for various practical applications. Nano-optical transducers can be utilized in a traditional optical system to obtain spots beyond the diffraction limit. This system has a number of disadvantages for potential use in consumer electronic markets due to its large body mass, size, price, and difficulties in mass production. A thin film waveguide with planar optical lenses and mirrors having a nano-optical transducer around the focus can address these problems. In this work electromagnetic and thermal modeling and design tools will be developed to investigate this device. A volume integral equation based solution will be used for the solution of Maxwell’s equation, and a finite element method based solution will be used for the solution of heat transfer equation. Designs will be identified to obtain small optical spots beyond the diffraction limit. Designs will also be optimized to obtain high transmission efficiency, which is necessary for practical applications such as data storage. The heating of the designs will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'New battery for an automated people mover'.

assistant: **Objectives**

Automated Guided Vehicles (AGV) are driver-ess vehicles. They are mostly used to transport cargo in a warehouse, or from a storage room to processing departments. Usually, they are electrically driven, fed by a battery pack. A relatively new application is to use AGV technology for people movers, which are typically small vans. This project is proposed to eventually develop and demonstrate an automated people mover (APM) for 8- 12 people to be used at airports and other shuttle services with busy traffic.This project focuses on the development of a new battery based on the Zebra battery technology, as the current standard lead acid batteries and NiCd batteries used in AGV's have many disadvantages, such as a low specific energy, a limited life, hi maintenance costs and unreliable performance in severe outdoors conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Genetic architecture of intralocus sexual conflict in a wild bird population'.

assistant: **Concept**

Optimal trait values often differ between the sexes. However, when male and female traits are controlled by the same genes, the influence of directional selection in one sex will be counteracted by opposite selection in the other sex, resulting in negative cross-sex genetic covariance for fitness and evolutionary stasis. Such a situation, termed “intralocus sexual conflict” (ISC), is believed to be common but has received little attention. A better understanding of the evolutionary dynamic of ISCs is essential to develop realistic sexual selection models, better understand population dynamics and assess the importance of ISCs in the speciation process. To date, studies that have investigated the genetic architecture of ISCs were restricted to laboratory populations and unlikely captured the complexity of natural systems. In addition, despite substantial theoretical advances on the potential mechanisms allowing the resolution of ISCs, empirical data clearly lags behind. In this study, I propose to take advantage of a long-term field study of great tit (Parus major) and state-of-the-art quantitative genetics and genomic tools to address these topics. Specifically, I plan to utilize a genetic linkage map composed of 10 000 polymorphic markers to identify genomic regions containing genes involved in ISCs, verify if these “islands of conflict” are co-localized with regions influencing known fitness-related traits such as body mass or clutch size, and test for variability in the location, number and strength of such islands over ontogeny, time, and environmental conditions. In addition, I suggest testing the novel idea that ISCs in great tit are alleviated by the evolution of genetic correlations between sex-specific fitness and offspring sex ratio and locate genes influencin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning. Recently, we uncovered that endothelial cells migrate extensively in the immature vascular network, and that endothelial cells polarise against the blood flow direction. Here, we put forward the hypothesis that vascular patterning is dependent on the polarisation and migration of endothelial cells against the flow direction, in a continuous flux of cells going from low-shear stress to high-shear stress regions. We will establish new reporter mouse lines to observe and manipulate endothelial polarity in vivo in order to investigate how polarisation and coordination of endothelial cells movements are orchestrated to generate vascular patterning. We will manipulate cell polarity using mouse models to understand the importance of cell polarisation in vascular patterning. Also, using a unique zebrafish line allowing analysis of endothelial cell polarity, we will perform a screen to identify novel regulators of vascular patterning. Finally, we will explore the hypothesis that defective flow-dependent endothelial polarisation underlies arteriovenous malformations using two genetic models. This integrative approach, based on high-resolution imaging and unique experimental models, will provide a unifying model defining the cellular and molecular principles involved in vascular patterning. Giv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Teaching Lytic Polysaccharide Monooxygenases to do Cytochrome P450 Catalysis' in the context of a Horizon Europe call.

assistant: **Objectives**

Lytic polysaccharide monooxygenases (LPMO) and cytochrome P450 (CYP) are copper- and iron-dependent, respectively,enzymatic systems that perform regio- and stereospecific oxidation of non-activated hydrocarbons in Nature. To control suchreactions in modern industry and biotechnology is of utmost importance in creating products of value such as secondgenerationbioethanol and products of value for i.e. the pharmaceutical industry. Due to the major drawbacks of using CYPs,including their partially membrane bound nature and the requirement of a reductase in combination with reducing agentssuch as NAD(P)H to transfer electrons to the active site for oxygen activation, it is highly desirable to develop new type ofcatalyst that can perform the same type of reactions. An attractive alternative strategy is to engineer LPMOs to perform CYPcatalysis. LPMOs are small, robust, easy to produce in large scale, and rigid water-soluble proteins with a plethora ofelectron donors. The extended, flat LPMO surface, with huge natural sequence variation and thus, likely, mutability, providesa fantastic scaffold for engineering access to the active site as well as substrate affinity. We propose to use LPMOsengineered to accommodate typical CYP substrates and immobilize this on solid supports to provide confinement necessaryin bringing the oxygen species together with the C-H bond to be oxidized in a tailored, ""closed"" environment. Moreover, therate of LPMO catalysis can be greatly enhanced compared to traditional CYP catalysis by the addition H2O2 in the presenceof low, priming concentrations of an external reductant to achieve efficiency constants (kcat/Km) in the order of 106 M-1s-1,which is typical for peroxygenases. The proposed ground-breaking research fits excellently well with the wor