RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'innovative STructures for improvEd Light colLection in ARgon-based TPCs' to be submitted under Horizon Europe.

assistant: **Abstract**

STELLAR (innovative STructures for improvEd Light colLection in ARgon-based TPCs) goal is to boost the advancement of noble gas and liquid optical Time Projection Chamber (TPC) detectors for rare-event searches, with Dark Matter (DM) being one of the most compelling puzzles of todays fundamental physics. STELLAR plans to contribute to the development of novel amplification structures based on Micropattern Gas Detectors (MPGDs) technology incorporating wavelength-shifting materials, capable of providing improved light collection and greater operating stability at higher gains. STELLAR programme can further contribute to the understanding of underlying mechanisms of signal formation in TPCs, opening the possibility of studying the electron extraction efficiency and electroluminescence in electronegative gas mixtures. This is a specially relevant topic considering the recent technological developments observed in DM searches with the use of Negative Ion TPCs, eventually optically readout. It is anticipated that the floating wavelength-shifting Field-Assisted Gas Electron Multipliers (FAT-GEM) mechanical characteristics and performance, can be a valuable alternative to current amplification structures used in noble-element TPCs for DM searches, for instance DarkSide-LowMass, or currently planned for long baseline neutrino experiment DUNE.


**Keywords:** Dark matter,  Optical amplification structures,  Wavelength-shifting materials,  Electroluminescence,  Light collection efficiency,  Micropattern Gas Detectors (MPGD),  Dual-Phase Time Projection Chambers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Increasing reforestation success with a novel fungi-based bio-compound material' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Reforestation projects have a failure rate of 25%, which generate internal project losses of around 450M€/year and reduces the financial sustainability of forestation at global level.At the same time, agricultural and forestry production as well as various agro-industries annually produce tons of waste that can be used in the production of 100% biodegradable biocomposites, allowing a useful destination for these wastes and contributing to the circular economy. With a central focus on the circular economy, we have created our company SPAWNFOAM specifically to commercialize our novel biocomposite material constituted by forest residues that function as a matrix that can be colonized by a fungal mycelium that will assume the role of bonding agent.Our first application of the Spawnfoam material is a plant pot specifically engineered for the reforestation market, that increases the survival rate of plants, and also their growth, due to proprietary functionalization of our pot with specific minerals and structures that provide water and nutrients directly to plants, while protecting root systems and are biodegradable.As a startup created in January 2017 specifically for the development and commercialization of SPAWNFOAM, this project is the core of our company’s strategy. We have secured a total of over 75.000€, of which 50.000€ from the Portuguese Environmental Fund to study the proof-of-concept of Spawnfoam and are now closing a 100.000€ grant to implement the pre-industrial proof of concept, our next milestone before large-scale implementation and global market replication, which we wish to study with the SME Instrument Phase 1 Feasibility Study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Polypterids – development and evolution of a ’living fossil’' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Polypterids or bichirs are a small group of African freshwater fishes often regarded as 'living fossils' because of their large number of primitive characters. Bichirs form the most basal branch of extant actinopterygians and have played an outstanding role in any study on the evolution of the major vertebrate clades. As a first step towards a modern treatment of these extraordinary ray-finned fishes, the present project will provide an up-to-date taxonomic analysis of the family Polypteridae incorporating for the first time all major museum holdings in Europe and the rest of the world. In a second step the phylogenetic relationships of all polypterid species will be analysed using state-of-the-art morphological and molecular methods. The core of the proposed project will comprise a detailed description and analysis of polypterid skeletal ontogeny, based on complete developmental series of the two extant genera Polypterus and Erpetoichthys, which are unique in the world. Characters relevant for the phylogenetic placement of polypterids among gnathostomes will be reevaluated from an ontogenetic point of view. This part of the study will also address important question of skeletal homology among basal osteognathostomes and aid in their resolution. The results will form an important reference for future studies on the comparative anatomy and phylogeny of basal vertebrate groups, as well as developmental genetic studies searching for the basal pattern of vertebrate development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'The design of morphing aircraft'.

assistant: **Objectives**

Morphing aircraft structures are flight vehicles that change their shape to effect both a change in the mission of the aircraft and to perform flight control without the use of discrete control surfaces or seams.Aircraft constructed with morphing technology promise the distinct advantages of being able to fly multiple types of missions, to perform radically new manoeuvres not possible with conventional control surfaces, to be more fuel efficient, and to provide a reduced radar signature.The Wright brother s used a method of wing-warping to twist the wings for roll control, and today many aircraft use flaps for take off and landing. The difference with morphing aircraft is the full integration of the shape control into the wing structure; a truly smart structure. In the limit one could envisage a flying wing with no discrete control surfaces at all.This project will take a systems view of morphing aircraft structures and will consider the structural design, airflow, structural dynamics, flight control system, aeroservoelasticity, and sensors and actuators. All these areas interact extensively, for example designing how the structure changes shape is critically dependent on the aerodynamic loads and the required flight control.While each topic is a huge area in its own right, a systems approach is the only appropriate way forward. The primary objective of this project is to produce a fully integrated simulation of a morphing aircraft including the aerodynamics, compliant structures, structural dynamics and flight control.Of primary interest will be an accurate assessment of the loads required to actuate the structure that can be used to optimise the power requirements and controllability of the aircraft. As part of this overall objective wind tunnel models will be built,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Process Analytical Technologies for Industrial Nanoparticle Production' (NanoPAT).

assistant: **Concept**

Nano-scaled materials are abundant in different stages of industrial manufacturing. Physical and chemical properties of these materials are strongly dependent on their size. Characterisation of mean size, size distribution, and shape of nano-scaled particles is very critical for the quality and efficiency of manufacturing processes. Yet, conventional characterisation technologies still show manifold shortcomings which represent a major innovation obstacle for manufacturers of nanoparticles. The NanoPAT consortium aims at closing this gap by the demonstration of 3 novel, real-time nano-characterisation Process Analytical Technologies (PAT), namely Photon Density Wave spectroscopy (PDW), OptoFluidic force induction (OF2i) and Turbidity spectrometry (TUS) including real-time data handling for digital process monitoring and product quality control. Those will be validated in 5 different industrial ceramic, polymer and mineral nanoparticles manufacturing and converting environments. This implies that innovating PATs will be paired with new data-analytical technologies in order to provide, for the first time, a real-time analysis for manufacturing processes of particles in the nanometer scale with sub minute temporal resolution. The NanoPAT consortium consists of 14 members, representing instrument developers, process data and modelling experts, academic process researchers, industrial processing experts, as well as innovation and dissemination specialists. The consortium profits from the broad involvement of its members in EU networks and ongoing H2020 projects. NanoPAT will intensively contribute to enhancing the innovation capacity of the European nanotechnology sector. As a result, the NanoPAT real-time nano-characterisation technologies will have reached TRL 6, promising
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Studying in vivo differentiation of monocytes into intestinal macrophages and their impact on gut homeostasis' to be submitted under Seventh Framework.

assistant: **Abstract**

Monocytes are central players in inflammation. Progress in understanding their differentiation in target tissues bears potential to manipulate their activities for therapeutic purposes. Here we propose to study the generation of intestinal macrophages (MΦs) as a paradigm, taking advantage of a unique experimental system to elucidate in vivo monocyte fates.The intestine hosts billions of bacteria that assist food uptake, but also pose a challenge, as we have to tolerate these beneficial commensals, yet rapidly mount immune responses to invading pathogens. Failure to maintain this balance causes inflammatory bowel disorders (IBD). Gut resident MΦs are key players in gut homeostasis and inflammation. Here we will study molecular parameters governing their generation from monocytes, as well as their interactions with the immediate tissue surrounding under pathological conditions. We focus on the molecular mechanisms leading to education of monocytes in small and large intestine using genome wide profiling of gene expression, chromatin state and transcription factor binding of monocytes and MΦs. Secondly, we will investigate epithelial and microflora-derived instructing cues, as well as sensory molecules on the MΦs that drive the education. Thirdly, we will study the impact of MΦs that fail to be trained and their role in the development of inflammation. Finally, we will use the insights gained to develop monocyte manipulation strategies that could aid the future development of IBD therapies.Our experimental system allows to follow the in vivo differentiation of engrafted monocytes, as physiological precursor cells, that acquire in a rapid synchronized development in the gut tissue physiologically relevant fates. Expected include (1) fundamental insight into the acquisition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'eHealth Week 2016' under Horizon 2020.

assistant: **Concept**

The Dutch Ministry of Health, Welfare and Sport will organize an international conference focusing on the implementation eHealth in health systems and the use by citizens. This conference will be organized in joint cooperation with the European Commission and aligned with the European conference of the Healthcare Information and Management Systems Society, and together is called the 'eHealth Week 2016'. It is scheduled 6-10 of June 2016 in Amsterdam, The Netherlands.


**Keywords:** eHealth, Health IT, Digital Society, Digital Single Market, Health, Cloud, Cyber-Security, eID, Social innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Competence Centre for Users of In-formation Systems on the Environment' (E-CUISINE).

assistant: **Concept**

The main objective of the project E-CUISINE is to establish a (thematic) network of the main institutional decision makers who promote early deployment of innovative Environmental Information Management Systems (EIMS) in Europe. The aim is to start a continuous discussion and exchange of ideas and visions on the potential of new systems and solutions in the area of EIMS. The aim is that the thematic network is to ultimately become a self-sustained network. The network will facilitate and promote exploitation and take up of ICT, with particular attention for results from the EU's IST programmes, as well as ESD and national programmes in the domain of environmental applications. Members of the network will include national environment agencies and environment ministries of EU Members States, accession countries and others including relevant services of the European Commission (DG Environment, DG Information Society), EEA, UNEP and OECD, as well as some major stakeholders.Objectives:To establish a (thematic) network of the main institutional users of Systems for Environmental Information (SEI) in Europe, with the aim to start a continuous discussion and exchange of ideas and visions on environmental problem, products and solutions in the area of SEI and with the intention to continue its existence after the 2,5 years for which EU-support is requested. The network will facilitate and promote exploitation and take up of ICT, with particular attention for results from IST programmes, as well as ESD and national programmes in the domain of environmental applications.Work description:The work to be done for E-CUISINE can be structured into five main tasks:1. Initialisation of the network and its infrastructure, followed by day-to-day management;2. Preparation and organisation o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Role of the PI3Kbeta isoform in signalling and cancer invasion' under Seventh Framework.

assistant: **Concept**

PI 3-kinases (PI3Ks) generate lipids in cell membranes which bind a variety of intracellular protein effectors, affecting their localization and/or activity. The PI3K signalling axis is one of the most frequently deregulated pathways in cancer. Mammals have 8 isoforms of PI3K, divided into three classes. The class I PI3Ks consist of a p110 catalytic subunit (p110alpha, p110beta, p110delta and p110gamma) bound to a regulatory subunit. Recent work has revealed that PI3K isoforms have surprisingly distinct roles in biology. Compared to the other class I PI3Ks, the organismal role and signalling of p110beta is poorly understood. My preliminary data point to a new and unexpected role of p110beta isoform in the control of breast cancer invasion and endosomal functions. My hypothesis is that these two phenomena are interconnected. In this proposal, I seek to investigate the role and mechanism of action of p110beta in breast cancer cell invasion. I will determine effectors downstream of p110beta involved in the control of cancer cell shape, motility and invasion and unravel molecular details of how p110beta transmits signals in the cell, with a focus on endosomal biology in the context on cell invasion. This will be achieved combining both cell-based in vitro 3D-invasion techniques using p110beta-selective pharmacological inhibitors and in vivo models of cancer invasion using mice expressing an inactive p110beta. An siRNA screen as well and advanced techniques of microscopy, biochemistry and cell biology will be performed. The results of these studies have implications for the fundamental understanding of PI3K function and the use of PI3K isoform-selective inhibitors in cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Boosting the reduction of the environmental impact of pharmaceutical products throughout their entire life cycle.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ETERNAL aims to contribute to sustainable development of pharmaceutical manufacture, use and disposal, by using and promoting full life cycle approaches covering design, manufacture, usage, and disposal, assessing the environmental risks of not only the API and residues/metabolites, but other chemicals and by-products of the production process. This type of approach is essential to take into consideration the types of green manufacturing approach under consideration by the pharmaceutical industry, as evidenced by the range and scope of case studies being undertaken within ETERNAL. Specific application of our risk and life cycle assessment approaches to the ETERNAL case studies is a key element of the proposed work and will provide industry and policymakers with key examples of how whole life cycle assessment may be used to evaluate the changes in environmental impacts expected due to the introduction of green manufacturing processes.


**Keywords:** safe-by-design, green-by-design, compliant-by design, fate of pharmaceutical, medicines, healthcare, recycled solvents, continuous manufacturing, ERA,develop, validate, carcinogenic impurity capture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Poverty, Resource Equality, and Social Policies' in the context of a Seventh Framework call.

assistant: **Objectives**

This project aims at revisiting the economics of poverty by using recent advances in welfare economics. First, poverty measurement theory will be enriched by taking account of individual preferences over the several dimensions of poverty. New poverty indices will be defined. They will be applied using panel data of material standard of living and subjective satisfaction to study the recent evolution of poverty in developed societies. Second, the ethical value of poverty reduction will be added to theories of social welfare based on equality of opportunities. New evaluation criteria of taxation policies will be derived. These criteria will be applied to the design of fiscal reforms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Living In a Material World' (LMW) targeting Seventh Framework.

assistant: **Abstract**

Living in a Material World (LMW) will stage the first Researchers Night in the Yorkshire region of the UK to celebrate and showcase the exciting variety and blend of research taking place at the University of Huddersfield and our European Partners involved in Materials Science. LMW will create a platform for public interaction through an exciting array of events in which materials research is made visible and tangible and researchers from many different disciplines are afforded the opportunity to present interesting, and relevant science demonstrations in the context of a major event for the town and surrounding area of Huddersfield,Yorkshire. The night will embrace a diverse range of researchers from textiles, chemistry, pharmaceuticals, computing engineering, health sciences and professionals within industry who are actively engaged in materials research.  LMW is an ambitious but achievable programme based around one of the most successful of the new Universities in the UK. LMW will stage a night to remember and provide a unique opportunity for young and older members of the public to see bright research talent putting on and sharing in a fantastic mix of education and entertainment for all to see and learn.""