RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Formal verification and neural lossless compression' (FVNLC) under Horizon Europe.

assistant: **Objectives**

Techniques based on neural networks (NNs), the study of which is often referred to as ‘deep learning’, have recently been shown to be extremely effective as a basis for data compression systems. I will develop the new field of ‘neural compression’, which has emerged around these ideas, focussing primarily on lossless compression in the two directions which I believe are most important:Scale: NNs go hand in hand with parallel hardware, and I will investigate new parallel compression algorithms for efficiently compressing huge quantities of data. Specifically, I will develop two entirely new compression paradigms: Firstly, compression of volumetric images using generative models based on 3D convolutions, applied to medical imaging, where teleradiology and new cloud-based analysis make the need for efficient compression particularly acute. And secondly, compression of audio and video using time-series latent variable models, known as ‘state space models’, which offer uniquely efficient utilization of parallel hardware.Systems: I will research, design and implement a domain specific language (DSL) for concisely expressing codecs which are guaranteed to be lossless by construction. Until now, implementations of compression systems always separate the implementation of the encoder from the decoder, and rely on an ad-hoc debugging and testing process to ensure that data are recovered correctly. During my PhD, I discovered that it is sometimes possible for a computer to automatically convert an encoder function into a decoder, and vice versa, potentially halving the amount of code. I will explore the limits, in terms of flexibility and efficiency, of this novel idea, using insights from ‘automatic differentiation’, a related functional transformation, on which I am a leading ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Modelling r&d for sustainable development'.

assistant: **Concept**

The Lisbon strategic objective for European Union to become the most competitive and dynamic knowledge based economy in the world capable of sustainable growth" necessitates today useful analysis for the people in charge of economic policies. The following proposal comes within the scope of this new perspective: it consist in an econometric model for European Union (NEMESIS), suited to long term analysis, with endogenous growth mechanisms for technical progress, to extend it to USA and Japan, the two major countries for R&D and Innovation. Then, new sustainable development scenario will be defined and analysed, that is to define sustainable development indicators, their objectives and then policy instruments that will allow reaching these objectives, and assessing the cost of these instruments."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Non-linear effects and backreaction in classical and quantum cosmology' in the context of a Seventh Framework call.

assistant: **Objectives**

Cosmology has gone through an amazing revolution during the last decade owing to the large amount of new precise observational data. These data strongly indicate the existence of two periods of accelerated expansion in the history of the Universe. One in the primordial universe,the so-called inflationary phase, and one at the present era. The link between data and models is made mostly by linear perturbation theory on a spatially homogeneous and isotropic Friedmann Universe. But beyond linear order many interesting effects appear, such as the non-Gaussianity, that should be present in the CMB, and backreaction (BR) effects. In particular, quantum BR of  primordial fluctuations can significantly modify the dynamics of the early universe and its observational signatures, while  classical BR of large scale structure (LSS) might contribute to the observed late time acceleration. The goal of my project is to quantify these non-linear effects more precisely. First, I want to connect the BR of the LSS to observations using a light-cone averaging prescription. Then, I want to evaluate  BR effects from magnetic fields generated during inflation in a consistent way both using the effective equation for the cosmological backreaction andthe data inside the backward light-cone of a physical observer. I also plan to obtain observationalbounds on BR from the study of the effective equation of state it induces and from its effect on early phases of expansion, from preheating to CMB decoupling passing through the relativistic era that takes place before the Big-bang nucleosynthesis. Also an alternative approach compared to the BR of the LSS will be then considered, I will investigate how a smooth expand Universe can be obtained from small, static inhomogeneous cells that are glued toget
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement' (MOBILISE-D), addressing dissemination and exploitation.

assistant: **Impact**

Optimal treatment of the impaired mobility resulting from ageing and chronic disease is one of the 21st century's greatest challenges facing patients, society, governments, healthcare services, and science. New interventions are a key focus. However, to accelerate their development, we need better ways to detect and measure mobility loss.  Digital technology, including body worn sensors, has the potential to revolutionise mobility assessment. The overarching objectives of MOBILISE-D are threefold: to deliver a valid solution (consisting of sensor, algorithms, data analytics, outcomes) for real-world digital mobility assessment; to validate digital outcomes in predicting clinical outcome in chronic obstructive pulmonary disease, Parkinson’s disease, multiple sclerosis, proximal femoral fracture recovery and congestive heart failure; and, to obtain key regulatory and health stakeholder approval for digital mobility assessment.  The objectives address the call directly by linking digital assessment of mobility to clinical endpoints to support regulatory acceptance and clinical practice. MOBILISE-D consists of 35 partners from 13 countries with long, successful collaboration, combining the requisite expertise to address the technical and clinical challenges. To achieve the objectives, partners will jointly develop and implement a digital mobility assessment solution to demonstrate that real-world digital mobility outcomes can successfully predict relevant clinical outcomes and provide a better, safer and quicker way to arrive at the development of innovative medicines. MOBILISE-D's results will directly facilitate drug development, and establish the roadmap for clinical implementation of new, complementary tools to identify, stratify and monitor disability, so enabling wide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'NAMS WITHIN INTEGRATED SAFETY & EFFICACY EVALUATION OF CHEMICALS AND PHARMACEUTICALS' (NAMWISE) under Horizon Europe.

assistant: **Objectives**

The vision of the NAMWISE project is to provide a supporting framework to pave a scientifically substantiated way towards a paradigm-shift in (eco)toxicology that will not rely on in vivo data. To fulfil its vision the project will leverage the acquired knowledge on New Approach Methodologies (NAMs) and then gather new input from all stakeholders to refine, improve and optimize their use in regulatory contexts for chemicals and pharmaceuticals. The project will merge under its umbrella inputs from a multi-disciplinary consortium comprising academia, NAM-developers, NAM users (CROs), regulators while reaching out towards societal expectations. The workplan of NAMWISE is organized along far-reaching objectives driven by the interest for all the stakeholders:1. Sustain and amplify the momentum built by similar initiatives by combining expertise on in silico tools, in vitro assays and a widespread network with external projects.2. Provide a pragmatic approach based on case-studies for hazard/risk assessment and drug efficacy that will guide the project in implementing NAMs strategies. These procedures will be submitted to a peer-review to ensure that what the NAM community receive is of a high standard. 3. Deliver an analysis of requirements in terms of standardization and validation of NAMs that benefits from the input of the PEPPER platform on pre-validation, a unique French initiative on NAMs based on public and private funding.4. Foster fruitful interactions between stakeholders catalyzed by several actions, including a series of workshops and training initiatives targeted on the needs of CROs identified during the project. 5. Propose a way forward for solving NAMs’ shortcomings and enhancing their drivers.Finally, the project will provide a white paper during its final
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Recombination-derived replication in the eukaryotic microbe Leishmania: a genome-wide process?' to be submitted under Horizon 2020.

assistant: **Abstract**

In any organism, the need to reproduce is paramount, with genome replication being the earliest step in the process. The machinery and mechanisms of DNA replication are widely conserved, with initiation occurring at defined bi-directional DNA synthesis sites termed origins. Though origins may not be conserved DNA sequences, they are defined through binding conserved replication initiator factors. In some circumstances, such as after DNA damage or origin deletion, origin-independent replication can be observed in cellular organisms and can be driven by recombination. However, origin-independent replication is not normally considered to be a genome-wide, central reaction of genome replication. Very recently, genome-wide mapping of DNA replication initiation in two species of the kinetoplastid parasite Leishmania revealed only a single locus-specific origin per chromosome. Analyses of Leishmania S phase length and DNA synthesis speed suggest that a single origin-based strategy is insufficient for complete genome duplication, indicating replication in these eukaryotic microbes relies on origin-independent initiation to support origin-directed initiation. In this proposal, I will test the hypothesis that stochastic origin-independent DNA synthesis initiation events occur throughout the Leishmania genome due to homologous recombination acting on DNA lesions. If correct, this work will reveal the first example of a cellular organism that uses origin-independent replication as a core feature of genome duplication. The genome-wide use of recombination-driven replication would alter our view of DNA replication evolution and would explain the remarkable genome plasticity of Leishmania, with implications for how the parasite adapts genome structure and gene expression in the face o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Assembly-disassembly-organisation-reassembly of microporous materials' (ADOR) targeting Horizon 2020.

assistant: **Abstract**

Microporous materials are an important class of solid; the two main members of this family are zeolites and metal-organic frameworks (MOFs). Zeolites are industrial solids whose applications range from catalysis, through ion exchange and adsorption technologies to medicine. MOFs are some of the most exciting new materials to have been developed over the last two decades, and they are just beginning to be applied commercially. Over recent years the applicant’s group has developed new synthetic strategies to prepare microporous materials, called the Assembly-Disassembly-Organisation-Reassembly (ADOR) process. In significant preliminary work the ADOR process has shown to be an extremely important new synthetic methodology that differs fundamentally from traditional solvothermal methods. In this project I will look to overturn the conventional thinking in materials science by developing methodologies that can target both zeolites and MOF materials that are difficult to prepare using traditional methods – the so-called ‘unfeasible’ materials. The importance of such a new methodology is that it will open up routes to materials that have different properties (both chemical and topological) to those we currently have. Since zeolites and MOFs have so many actual and potential uses, the preparation of materials with different properties has a high chance of leading to new technologies in the medium/long term. To complete the major objective I will look to complete four closely linked activities covering the development of design strategies for zeolites and MOFs (activities 1 & 2), mechanistic studies to understand the process at the molecular level using in situ characterisation techniques (activity 3) and an exploration of potential applied science for the prepared materials (ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unravelling the role of neuronal antibodies and innate immunity partnership in human autoimmune encephalitis'.

assistant: **Innovation**

Autoimmune encephalitides (AE) are severe brain disorders mediated by antibodies against neuronal proteins, such as the N-Methyl-D-Aspartate receptor (NMDAR). The antibody effects are reversible, explaining recovery after antibody-depleting therapies. However, it is unknown why many patients have incomplete recovery and persistent deficits. In these cases, additional immune mechanisms might be at play.The objective of ImmuBRAIN is to define how the adaptive immune response (autoantibodies) cross-talks with innate immune-mechanisms, resulting in neuronal dysfunction or death, by using NMDAR encephalitis as a disease model. Cutting-edge antibody engineering will define the unexplored contribution of antibody glycosylation (which modulates innate functions) to neuropathology.ImmuBRAIN combines human studies with experimental models. Human studies will extensively profile patients NMDAR antibodies using a novel antibodyomics platform; characterize the compartmentalized antibody responses between brain and periphery using B-cell receptor repertoire analyses; define the distribution of brain innate infiltrates and quantify neuronal death using advanced microscopy. In vitro models will determine the effects of patients and glycan-modified antibodies on neurons using confocal microscopy and electrophysiology; explore the neuron-microglia interactions during trogocytosis using super-resolution and live cell imaging. Finally, a new mouse model of NMDAR encephalitis will serve to define the dynamics of antibody and innate responses over time and at different disease stages, and explore the therapeutic role of in vivo antibody glycan modifications in reversing the observed behavioural and molecular alterations.These findings will revolutionize the current understanding of innate im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HUMANISM BEHIND THE IRON CURTAIN: ITALIAN RENAISSANCE STUDIES IN THE SOVIET UNION' (2014-2020).

assistant: **Innovation**

The main goal of the project is to examine the Italian Renaissance Studies in the Soviet Union taken as an independent and considerably isolated scholarly tradition, but placed in the broader context of intellectual history and development of Renaissance historiography in the twentieth century. The project seeks to comprehend why and how Italian Renaissance philosophy, art and history was extensively studied in Soviet Union, what was the contribution of the Soviet scholars to the field on the international level, that is how they reshaped our understanding of this movement, and how these scholars, whose financial opportunities and academic mobility were significantly limited, participated in the international academic networks. The project will be the first comprehensive study of the Italian Renaissance scholarship in the Soviet Union examined as independent national tradition, but placed in the international discourse on Renaissance humanism. The project will contribute to the field of Renaissance Studies, Russian/Soviet studies, comparative and global intellectual history, and gender studies.


**Keywords:** Historiography of Renaissance, Renaissance humanism, Russian and Soviet Studies, global history of historiography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Centre of excellence for advanced mechanical systems - getting european dimension'.

assistant: **Innovation**

CoE for Advanced Mechanical Systems answers 5FPGrowth KA1TRA1.3 eco-efficient processing and design. The R&D activities involve virtual designing, making prototypes, man-machine interactions, and environmental impacts. The objectives of the proposal are to strengthen the CoE enabling to develop scientific and technical excellence, to integrate with ERA, to transform the potential towards advanced technologies and environmentally friendly systems. They will be achieved by a realization of a research programme, twinning activities with EU R&D organizations, networking on the national, NAS, NIS and EU levels, harmonization of standards and design rules, industry trainings, exchange of researchers, excelling of management activities, conferences and dissemination of results. These activities will contribute towards solving the problem of the industry modernization, adaptation of new challenges, quality development, minimization of use of natural resources and smoothing the integration into ERA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Green responsibLe privACy preservIng dAta operaTIONs' to be submitted under Horizon Europe.

assistant: **Abstract**

From edge to cloud, big data analytics is growing fast, and its energy consumption has become a reason of concern for national grids and they generate significant carbon emissions. The GLACIATION project aims to address this issue through energy-efficient privacy preserving data operations. By developing a novel Distributed Knowledge Graph (DKG) that stretches across the edge-core-cloud architecture, reduction in the energy consumption for data processing will be achieved through AI enforced minimal data movement operations. GLACIATION will achieve significant power consumption reduction through optimizing the location where analytics are carried out and where data is placed. The projects Metadata framework will provide tools that incorporate privacy and trust aspects in the data operations. GLACIATION is demonstrated on three relevant industry settings which benefit from optimized data movement and power consumption reduction. More specifically, GLACIATION use cases cover public-service, manufacturing, energy and enterprise data analytics.


**Keywords:** energy efficiency, data operations, public administration, industry, manufacturing, data management, privacy, edge, cloud, Artificial Intelligence, Distributed Knowledge Graph