RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'GLOBAL SMART SPACES' to be submitted under Fifth Framework.

assistant: **Abstract**

Our investigation is into underlying computational models for Ambient Systems on a global scale, which allow appropriate information to pass freely around the underlying infrastructure, allowing devices to be modular and communicative with other devices, in networks that keep recollection of use and user's characteristics whilst respecting privacy. Our models take explicit descriptions of context (physical and computational) and use these to drive the underlying infrastructures. Our investigation is into underlying computational models for Ambient Systems on a global scale, which allow appropriate information to pass freely around the underlying infrastructure, allowing devices to be modular and communicative with other devices, in networks that keep recollection of use and user's characteristics whilst respecting privacy. Our models take explicit descriptions of context (physical and computational) and use these to drive the underlying infrastructures.OBJECTIVES1. the precise understanding of how services (physical and information) are used and how users interleave various contexts (home life, work life, etc.) during usage;2. the natural representations of these usage patterns and contexts via narratives;3. novel programming and systems support for the narrative representations and execution;4. the development of essential middleware infrastructures for hybrid peer-to-peer and hierarchical systems;5. the development of abstract machine for interaction devices.DESCRIPTION OF WORKResearch focus:GLOSS takes the view that movement in real space is a source of opportunities. By leveraging the features of spaces - their uses, interconnections etc - we seek to use peoples' locations and movements (context) as both a source of task-level cues and a guide to appropriate informa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Predictive Reagent Antibody Replacement Technology' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Predictive Reagent Antibody Replacement Technology (PRe-ART) will create a foundational new technology platform to completely replace conventional antibody technology within medical diagnostics and basic life science research. In a multidisciplinary approach combining basic science, protein engineering and computational prediction, Pre-ART will generate non-antibody components which can be combined in an entirely modular fashion to create molecules that bind any peptide of choice. Such a biotechnological revolution is timely because of current failings in the reagent antibody market, after forty years still based on monoclonal antibodies (mAbs) to detect biomolecules, when 50% of all commercial reagent mAbs have been shown to not function correctly. By combining information science with directed evolution, PRe-ART will ultimately create an encyclopedia of pre-designed and experimentally pre-selected modules (like biological Lego bricks) that may be combined, without any further experiment, to generate unique binding molecules that function as antibody replacements. The PRe-ART vision is that mAbs for many applications in biological research will be replaced over the course of a decade by these designer molecules, with the potential to completely disrupt the industry selling low-quality commercial animal-derived reagent antibodies, and thus create a major new technology for biological research. Thus, PRe-ART will ultimately contribute not only to the health and wellbeing of the EU citizen through improved diagnostic capability, but also to the economy of the EU through the development of myriad detection products, enabled by this foundational platform technology. The interdisciplinary PRe-ART project will achieve this goal by bringing together three leading labs from dif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improving cellular cancer immunotherapy using chemotactic metabolite receptors' under Horizon Europe.

assistant: **Concept**

Chimeric antigen receptor T cell (CAR T) cellular immunotherapy has revolutionized treatment for patients with hematological cancers, but largely failed to provide benefits for patients with solid tumors. Ineffective CAR T migration into solid tumors caused by the lack of recruitment signals, including chemokines, is a key gap for current cellular immunotherapies. The very common accumulation of metabolites in tumors provides a yet unrecognized opportunity to guide immune cells into tumors. Therefore, my overall research objective for this project is to generate and use novel chemotactic metabolite receptors (MetaboTract) to enhance the efficacy of CAR T and natural killer (NK) in solid tumors. This innovative approach is expected to impact the therapeutic options for cancer patients with poorly infiltrated tumors and enhance the EUs competitiveness in the rapidly expanding market of cellular immunotherapies. Applying the gained knowledge on CAR NK cells could additionally reduce treatment costs and accelerate deployment of cellular therapies to patients. During the MSCA fellowship, I will learn vital new skills including cell migration assays, in vivo models for immunotherapies, project management, exploitation, and leadership in the renowned laboratory of Prof. Sebastian Kobold at the Ludwig-Maximilians-University (LMU) in Munich. The expertise of Prof. Kobolds lab with chemokine receptor CAR T cells and in vivo models together with my complementary skills in cellular immunology, NK cells, imaging, and bioinformatics gives the project a high likelihood of success. The publication of the results, the gained knowledge and skills, and the demonstrated mobility will strengthen my scientific independence and help me achieve my career goal of becoming a research group leade
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sounding the Depths of Providence: Mineral (Re)generation, Natural Resources, and Human-Environment Interaction in the Early Modern Period' in the context of a Horizon 2020 call.

assistant: **Objectives**

SOUNDEPTH is a research project on early modern conceptions of ore generation within the broader theoretical and practical contexts of natural philosophy, Earth sciences, and human-environment interactions. In carrying out an interdisciplinary study of these subjects, the project aims to disclose new insights into our understanding of geological phenomena and natural resources, thus giving a significant contribution to the history of science, environmental history, and to the ongoing environmental debate.These goals will be achieved through the acquisition of new scientific knowledge and skills, the strengthening of the existing ones, and the implementation of an interdisciplinary work that will combine 1) an in-depth analysis of the sources that influenced the early modern debate on mineral generation and 2) a confrontation with the existing secondary literature on the subject, with 3) the replication in laboratory of significant alchemical and mineral processes and the comparative exploration of historical mining sites in Europe.The outgoing phase at Johns Hopkins University (USA, month 1-24) will focus mainly on the analysis of sources and studies, on the acquisition of new scientific knowledge (geochemistry, geobiology, alchemy, experimental history of science), and on laboratory replications. The secondment period at Radboud University Nijmegen (Netherlands, month 25-27) and the incoming phase at Ca Foscari Venice (Italy, month 28-36) will be especially devoted to refining my existing expertise (history and philosophy of early modern science, Earth sciences, environmental history, ecology, digital humanities, textual criticism) and to the exploration of historical mining sites.Research outputs (conference presentations; open access, peer-reviewed publications; open
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TOPOLOGICALLY DYNAMIC SCALED OUT DATA CENTRE NETWORKS FOR ENERGY EFFICIENCY AND MANAGEMENT', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The proportional cost of networking in large Data Centre(DC) environments has increased from single digit % up to 30%, as DC scaled-out network architectures have been built to interconnect planet scale compute clusters. In addition,  the need to efficiently employ all DC compute and storage resources in a general purpose manner, require that all resources can be brought into use on an ""as needed"" basis by the User software application. Further, with the ever increasing port data rates in DCs and as the symptoms of exhaustion of switching silicon performance continue to emerge at 100G line rates, and above, there is an urgent need for a smart/novel crosslayer (software to photonics) technology approach to achieve viable economic solutions for next generation DCs networks.  Aperilink seeks to bring a patented software optimisation solution to the hybrid switching market place. This solution will augment current packet switches with optical flow switches, plus software networking,  enabling next generation integrated networking solutions.  This will benefit Large Enterprise users of private and hybrid DCs, both in Europe and Globally. The significant CAPEX cost reduction, coupled with the  reduced OPEX costs enabled by photonics, present a significant commercial opportunity to Aperilink.Photonics has a major part to play in next generation Data Centres and the A-STREAM project seeks to analyse the market feasibility of the use of crosslayer technologies in enabling this transition and adoption. Further, the current project seeks to perform market research in chosen market verticals, analyse the structure of these markets and to develop a Go-To-Market Strategy, including  pricing and margins.With a successful execution of A-STREAM in SME Instrument Phase I, it is intende
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Applied Mathematics in our Changing World, First EMS-SIAM Conference' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This is the first joint conference of the European Mathematical Society, EMS, and the Society of Industrial and Applied Mathematics, SIAM. SIAM is a North American, mainly US, based society, which however has worldwide many members outside north America. EMS and SIAM are currently discussing the next joint meeting. The European Mathematical Society covers all of Mathematics, pure, applied up to and including industrial applications. Since there is no society for applied mathematics in Europe EMS wants to bring together all applied mathematicians in Europe, especially the young ones and the very active researchers. For this reason the topics have been chosen very broadly. A main feature of the choice of applications is that these are modern applications, rather than classical ones. It was natural to do such an event together with SIAM, which already has a quite large membership among Europeans.Key features of this conference will be: - applications of mathematics in the following 10 fields: medicine, biotechnology, material science, environmental science, nanoscale technology, communication, traffic, market and finance, speech and image recognition, engineering design (for a more detailed description of these fields, see the enclosed dossier) - 10 invited plenary speakers, one from each of the above mentioned fields, will deliver keynotes. All these speakers are world leaders, 5 will be Europeans and 5 from the US. - a key feature of the conference is the minisymposia. These will attract the very best active researchers together with their students. In a minisymposia a special topic will be discussed by experts giving the young researchers the opportunity to get the most recent results in this field on a top scientific level in a compact form. The selection of the topics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Preparatory action to Boost Global Crop Yield for Food & Nutrition Security and fueling a Bioeconomy' (CropBooster-P) targeting Horizon 2020.

assistant: **Abstract**

Increasing  global crop productivity will be central in meeting some of the greatest challenges facing mankind: How will we sustainably feed 9.7 billion people by 2050, while also achieving the transition from a fossil economy towards a bio-economy in order to mitigate, or possibly reverse, the effects of global climate change? How can we assure and maintain the nutritional quality of our future crops? Additionally, how can we provide new crop cultivars adapted to the constraints imposed across vast areas by climate change? A doubling of global crop productivity is required to produce enough plant biomass to achieve food and nutrition security, as well as to meet the demands of a future bioeconomy. To ensure both Food and Nutrition Security this increase in crop production must be achieved without any loss of nutritional quality. In addition, future agriculture will require crops that combine sustainability - they must efficiently using scarce resources like minerals and water and preserving Earth’s biodiversity - with a high resilience to adverse climate conditions. In order to meet these challenging demands, our current crop plants will have to be re-designed and a “future proof” profiling is urgently needed. With a multitude of possible crops and genetic changes, combined with multiple environmental changes, policy and societal challenges, progress could be mired in a seemingly insurmountable complexity.  CropBooster-P will address this by identifying priorities and opportunities to adapting and boosting productivity to the environmental and societal changes.  While engaging with the public from the beginning, and by mobilizing European plant sciences, our objective is to produce a White Paper – a Roadmap –  that will describe the pathway to sustainably doubling Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Action “Establishing services enhancing the innovation management capacity of SME's in the Enterprise Europe Network”'.

assistant: **Innovation**

In order to address the challenges of increasing SMEs innovation potential and enabling them to bring their innovative ideas to the market, new programmes and support systems have been designed. Europe recognises the importance of innovation and SME’s as growth drivers and as such, this action shall provide specialized consulting services addressing the innovation management capacity of SMEs which possess significant innovation activities. Beneficiaries of the SME instrument shall as well receive support to enhance their innovation management capacity through this action.The Enterprise Europe Network is embedded in the regional innovation ecosystem within Wales, and will provide support for raising the innovation capacity of Welsh SMEs. This will be completed under the two types of 7 day packages of support available, which are: 1) Enhancing SME Innovation Management Capacity 2) Key Account Management for the beneficiaries of the SME Instrument. The objective of these services will be increasing and accelerating the economic returns from innovation in SMEs. A number of deliverable outputs have been defined in section 2.1 in order to ensure that the project meets the overall objective. The aim will be to strengthen the innovation capacity of SME’s and their contribution to the development and commercialisation of new technology. By expanding relevant networks, increasing the research effort and better exploitation of IP, Wales can maximise the ROI. The overall objective is to:• increase the economic impact from European R&D and innovation investment•  improve the  innovation capability of SMEs in Wales


**Keywords:** Enhancing Innovation Management Capacity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Commercialization of 3D scaffold platforms for neuronal cell culture models', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The ongoing MESO-BRAIN project aims at the development of functional three-dimensional (3D) human stem cell derived neural networks on laser fabricated artificial scaffold platforms. Previous and contemporaneous attempts at generating 3D neural networks usually rely on biological matrices or gels providing randomly connected networks. In MESO-BRAIN, 3D scaffolds are integrated with conductive electrodes that enable both electrical stimulation of the network development and recording of the neural network activity. The development of such technological platform will be foundational for a new era of biological and medical research. In this FET Launchpad “Scaffold-Needs” project, we aim to make 3D scaffolds and 3D scaffold platforms with integrated electrodes commercially available via MESO-BRAIN spin-off company Laser nanoFab GmbH. We envisage that the 3D scaffold platforms will enable scientific and medical researchers to use them for a variety of studies e.g. as 3D neuronal cell models for investigations of fundamental mechanisms of human neuronal activity; in tests of pharmacological and toxicological compounds, in modelling of neuronal diseases, etc. There is a unique opportunity for the creation of a marketable product stemming from the work already performed and intended in MESO-BRAIN project. The commercialisation of MESO-BRAIN 3D scaffolds in collaboration with Laser nanoFab GmbH with FET Launchpad support represents an added value innovation which will raise the TRL level to TRL 5 and provide a solid basis for continued exploitation in the industrial sector. Depending upon the market analysis feedback, a 2nd round of optimisation and modification of the 3D scaffold platforms may be essential based upon special needs of potential customers to better target the mar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine'.

assistant: **Objectives**

A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apoptosis or non-apoptotic (necrotic, autophagic, mitotic) cell death, perform data mining to integrate system-wide analyses on cell death (genome, epigenome, transcriptome, proteome, lipidome data), and use high-throughput methods (“omics”, CHiP-chip and genome-wide siRNA screens) for the experimental exploration of death pathways in human cell lines in vitro and in relevant disease models (in vitro in human cells and in vivo in mice and Drosophila). In addition, the consortium will establish mathematical models of lethal pathways to devise algorithms that predict apoptosis susceptibility and resistance, obtain data (genome, transcriptome, proteome, lipidome) on clinical samples (cancer cell lines, cancer tissues, serum, and blood samples) and perform biostatistical analyses on them in order to demonstrate the contribution of apoptotic process in human cancers and AIDS. Then, the consortium will integrate the knowledge into mathematical models for the optimal interpretation of clinical data, aiming at optimal diagnostic and prognostic performance as well as at the identification of possible therapeutic targets for the treatment of cancer and AIDS.