RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Three-Phase Topological Superconducting Diode Effect' (3PhaseTSDE) under Horizon Europe.

assistant: **Objectives**

Quantum computers promise unprecedented computational power, yet the lack of scalable, reliable quantum circuit components remains a major bottleneck to realizing practical quantum processors. A single error in a quantum circuit can corrupt an entire computation, so fault tolerance is essential to truly unlock quantum advantage. Here, topological qubits offer a leading pathway to fault-tolerant quantum computation, but their integration is currently hindered by the lack of essential directional elements.We address this gap with a novel three-phase topological superconducting diode that provides dissipationless, fully integrable directional control within topological materials. Our approach is compatible with existing superconductor and nanofabrication processes, requires only minimal magnetic fields, and can be integrated seamlessly into topological quantum processors. It enables scalable, energy-efficient quantum circuits that preserve coherence, eliminate bulky external components, and unlock seamless integration of Majorana-based qubits into functional processors. Our technology lowers error rates and cuts error-correction overhead, and may offer scalable, energy-efficient, and commercially viable circuits.Our PoC will reach TRL 4 by combining real-material simulations with experimental validation, optimizing three-phase control for reliable cryogenic operation within standard superconducting fabrication processes, while simultaneously defining the exploitation pathway and commercialization strategy. This PoC is a pivotal step toward practical quantum processors, providing a directional superconducting element for topological and superconducting qubit architectures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease' (4DCELLFATE), addressing dissemination and exploitation.

assistant: **Impact**

Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remodelling and Deacetylation (NuRD) complex and the Polycomb Repressive Complexes (PRCs), modulate chromatin structure to control stem cell renewal, lineage commitment and differentiation. Moreover, they are clearly implicated in cancer.The goal of 4DCellFate is to understand how the PRC/NuRD complexes and their plethora of interactions (protein/protein, protein/nucleosome, protein/nucleic acids) regulate cell fate. To obtain this global, quantitative and dynamic – 4D – understanding of the structure/functions of these two multi-protein machines during ES cell differentiation and in different disease states, we propose a large scale multi-disciplinary “data-gathering” approach combining European excellence in interactomics (affinity purification, quantitative mass spectrometry-based proteomics, ChIP-seq analysis, light microscopy), structural biology (X-ray crystallography, NMR, native-state mass spectrometry, Electron Microscopy, biochemistry/biophysics), cellular, tumour, and computational biology. We expect to significantly advance the technology, mainly in the fields of proteomics, structural biology, and small molecule screening, and to make our knowledge, reagents and data publicly available to the scientific community.The ultimate outcome of 4DCellFate will be to lay the foundations for understanding the role of the PRC/NuRD complexes in ES cell differentiation and cancer, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Biomechanical interactions in tissue engineering and surgical repair'.

assistant: **Objectives**

The aim of this project is to develop a protein-based subunit vaccine against diseases caused by S. pneumonia by preventing its colonisation of the human nasopharinx. Target antigens will be identified among surface proteins which act as adhesins. The first years will be devoted to the discovery of new adhesins and to determine the degree of their allelic/antigenic variation. The role of putative adhesins, selected via genomics and bioinformatics, will be tested using single and combined knock-out mutants in adhesion assays and in a mouse pharyngeal colonization model. Mouse immunization studies will be performed using purified recombinant proteins and the live vaccine vector S.gordonii. Mucosal delivery will be by the nasal route and by colonization of the upper respiratory tract with the live vector. Protection from colonization and from invasive disease will be evaluated, together with the local and systemic immune responses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High current bi-2223 conductors with innovative wire geometry for power applications (BIG-POWA)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

In the face of stiff competition from USA and Japan, this project will maintain Europe's depth of strength in the RTD of high temperature super conducting materials, so that European Industry can take full advantage of the new market in HTS applications that will emerge ten years from now. Round and square Bi-2223 wires with high currents will be designed, manufactured and then transposed and stranded for a power-link and a coil. New-loss conductors will be developed with twisted filaments and resistive barriers over 200m lengths. New reaction mechanisms will be defined with new precursor powders that will significantly increase the current capacity of Bi-2223 conductors. This work will be supported with new 3D modeling and characterization studies. These will aid the design of better geometries and quantify the conductor benefits.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Portable, versatile and multifunctional monitoring system that assures the energy output of low cost thermal solar facilities'.

assistant: **Innovation**

Our proposal is intended to take advantage of the traditional energy auditing procedure and audits performed by a monitoring system, while avoiding the disadvantages through a so-called portable monitoring system" that consists of: 1. Stand-alone sensors (temperature gages, flowmeters, pyrometers, etc.), that can store data for a predetermined time period (for instance, a week) every 15 minutes and fitted with their own microprocessor and memory, which is independent from that of the datalogger. 2. Development of a "portable reader" for these sensors, which would be fitted temporarily in the facility and would dump later the information to these "portable readers". 3. Development of a software program to determine the universal energy balances in each facility and once the hydraulic diagram of the installation has been plotted beforehand: - The minimum number of sensor gages required would be determined to define the energy balances in each component of the facility (boiler, pump, heat pump, solar collector, etc.) as well as on a global basis. - The energy balances will be computed as automatically as possible once the data collected from the facility by the portable sensor gages is dumped to the memory. 4. The sensor gages kit would be carried in an auditing handheld case. The gages have to allow for simplified fitting that will not disturb the facility's operations (contact gages, flowmeters to be fitted under load, etc.). The system is rather convenient since it can be used to show the possible buyer of a solar facility how much money and energy are wasted, and achieves this end using, instead of a complex and permanent monitoring equipment, just some components fined in a few hours, while the facility continues operations undisturbed"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enhanced Arrivals and Departures' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

In order to meet forecast traffic growth, PJ01 will develop concepts, tools and procedures to increase the capacity of Terminal Manoeuvring Areas (TMAs) in a safe, cost-effective and environmentally sustainable manner.  This will be achieved by taking advantage of the latest technological developments from both an airborne and a ground-system perspective and through the secure sharing of data. The needs of all Airspace Users will be addressed including General Aviation and Rotorcraft. All types of European TMA environments will be considered. For low to medium density/complexity TMAs the driver will be to exploit the environmental benefits achieved from Continuous Climb Operations, Continuous Descent Operations and improved arrival sequencing.  For the capacity-constrained high-density/complexity TMAs, particularly including multiple airports, the focus will be to minimise delays and improve resilience alongside providing environmental benefits. This will be achieved by enhancing arrival and departure management by the dynamic use of precision navigation routes.  Traffic flows will be optimised by improving the integration of the management of arrivals with departures and by improving the capability to balance traffic demand and available capacity across the network and airports. To provide increased resilience in poor weather and a reduction in go-arounds, investigations will assess the use of tools that display traffic information in the cockpit. This will help manage airborne spacing, sequencing and merging with other aircraft, under the overall control of Air Traffic Control in systemised airspace.  To ensure that the full benefits are achieved and that the expected performance improvements are realised in the context of the overall ATM network, close co-ordination
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An advanced data management system for G protein-coupled receptors' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

G protein coupled receptors (GPCRs) are the targetin the human body for most of today's medicines. Almost all European pharmaceutical companies market GPCR agonists or antagonists as drugs aimed at diverse disease states such as hypertension, sleeplessness, anxiety anddepression. The introduction of rational drug design has greatly enhanced the importance of fast and flexible access to data of different origins. Many different databases are queried routinely by academic and industrial scientists in the GPCR field. It would be a significant step forward in the rational drug design process if all existing GPCR related data were to reside in one well annotated, integrated database that could be queried in an intelligent manner. The goals of the proposed grant are: - Gathering data related to all aspects of G protein coupled receptors; - Verification of data quality and consistency; - Annotation of individual data items; - Storage of all heterogeneous data in an object oriented database; - Design of intelligent query systems and data-based inference engines; - Automation of the first four items. The participants will pursue these goals and combine the results in a database system that can be queried openly via computer networks. The innovation potential of this project is greatest for the rational design of drugs. Pharmaceutical industries will use this database during the design cycle (lead finding - lead optimisation drug optimisation) of new and better medicines. Four European companies have made a commitment to function as beta-testers during the development of the system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The industrial use of genome resources in Europe' (1994-1998) under Fourth Framework.

assistant: **Objectives**

This multi-centred research project (GB, FR, BE) aims to assess the impact of EU basic research programmes in genome analysis (Arabidopsis, Yeast, Drosophila, B. subtilus, various extremophiles and human) which now appear to have clear industrial applications. The overall goal is to provide an analysis by which the industrial utility of genome information can be evaluated and the mechanisms for optimal European exploitation identified. Europe has played a major role in the application of sequencing and mapping technologies in collaborative genetic research which is leading to the definitive description of the complete genetic (DNA) material in whole organisms, from pathogens to humans. Determining how industry can best exploit European strength in genome analysis through collaboration and technology transfer between the public and private sector will be a central objective of the research. Although industrial strategies towards the commercial development of genome data are at an early stage, there is no doubt that research in this area is being actively pursued by large and small companies in Europe, the US and Japan. Despite the major European commitment to public sector genomics, there are no European companies in this area. As the commercial exploitation of genome research gathers pace world-wide, it is clearly vital to understand how European companies are responding. An essential step in this direction is an analysis aiming to reveal which European MNEs and SMEs use genome information and for what purpose. In order to achieve the objectives, the research has been divided into four discrete but related work packages. These are: (a) a comprehensive analysis of the sectoral specialization of European companies using genome information, from SMEs to multinationals (MNE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Genetic interaction networks in a self-renewing human tissue' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Both epigenetic factors and microRNAs have the potential to control transcript levels of large sets of genes through transcriptional and post-transcriptional mechanisms. Faithful stem cell function is crucial for tissue maintenance and repair throughout life and requires these machineries to establish specific and dynamic transcription programs. However, how miRNAs and chromatin-factors cooperate to achieve this is poorly characterized. I previously developed genetic screening and computational approaches to determine the contribution of functional interplay among 332 chromatin-factors to epidermal differentiation. Now, I will pioneer the concept of genetic interactions between coding (chromatin-factors) and non-coding RNAs (miRNAs) using primary human epidermal stem cells as a well-characterised and clinically relevant model system. My lab will: (1) silence all individual miRNAs expressed in these cells to measure their contribution to stem cell renewal and differentiation. Innovative Bayesian statistics will then be employed to predict which miRNAs and chromatin-factors function together in functional/genetic interactions. (2) We will investigate the mechanism underlying these interactions using genomic, proteomic and cell biological approaches with particular attention to direct cooperation of nuclear miRNAs and chromatin-modifiers in transcription regulation. Together, understanding which genes in the genome cooperate, and how they do so, will not only deepen our understanding of normal biology, it will also help rationalise targeted (combination) therapies for disease, a major goal in modern clinical medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Connected Health Early Stage Researcher Support System' (CHESS).

assistant: **Innovation**

Changing demographics and increasing pressure on health related resources mean that new models of care must be found.  Fortunately, technology developments and increasing digital literacy mean that we can now put the correct information in the correct hands at the correct time.  This is connected health and it allows patients, clinicians, and planners to make better decisions.  Ultimately, these decisions can save lives, save money and ensure a better quality of life for the patient during and after treatment.Connected Health is an emerging market and an emerging science.  It requires “t-shaped” individuals with deep disciplinary expertise allied to a broad understanding of a variety of domains including business, economics, life science, health science, computer science, social science and engineering.  Current research and training programmes in Europe do not address this need and adoption of Connected Health solutions and practices is limited as a result.  CHESS will develop connected health scientists and champions who have a broad understanding of multiple domains, who can communicate in an interdisciplinary world and who can operate across the education, industry, health and policy sectors.CHESS will include intersectoral secondments, interdisciplinary communication skills, public engagement and outreach with particular focus on patient, clinician and policy-maker audiences.  This will build on the programme of interrelated core research projects which will address gaps in the knowledge and evidence base for Connected Health in terms of health economics, use of big data, personal sensing, business modelling, navigating markets and ecosystems, change management and user-led design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Holistic Approach of Spray Injection through a Generalized Multi-phase Framework' under Horizon 2020.

assistant: **Concept**

Development of fuel injection equipment (FIE) able to reduce pollutant emissions from liquid-fueled transportation and power generation systems is a top industrial priority in order to meet the forthcoming EU 2020 emission legislations. However, design of new FIE is currently constrained by the incomplete physical understanding of complex micro-scale processes, such as in-nozzle cavitation, primary and secondary atomization. Unfortunately, today’s computing power does not allow for an all-scale analysis of these processes. The proposed program aims to develop a large eddy simulation (LES) CFD model that will account for the influence of unresolved sub-grid-scale (SGS) processes to engineering scales at affordable computing time scales. The bridging parameter between SGS and macro-scales flow processes is the surface area generation/destruction occurring during fuel atomisation; relevant SGS closure models will be developed through tailored experiments and DNS and will be implemented into the LES model predicting the macroscopic spray development as function of the in-nozzle flow and surrounding air conditions. Validation of the new simulation tool, currently missing from today’s state-of-the-art models, will be performed against new benchmark experimental data to be obtained as part of the programme, in addition to those provided by the industrial partners. This will demonstrate the applicability of the model as an engineering design tool suitable for IC engines, gas turbines, fuel burners and even rocket engine fuel injectors. The proposed research and training programme will be undertaken by 15ESRs funded by the EU and one ESR funded independently from an Australian partner; ESRs will be recruited/seconded by universities, research institutes and multinational fuel in