RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From Topological Matter to Relativistic Quantum Vacuum' under Horizon 2020.

assistant: **Concept**

The structure of relativistic quantum vacuum (RQV) in our Universe is one of the main challenges in modern physics. We plan to advance our understanding of the vacuum structure and on this basis treat the most important unsolved problems in physics, such as the cosmological constant problem (why the measured vacuum energy is 120 orders of magnitude smaller than estimates from the zero point motion) and the hierarchy problem (why the masses of the known particles in the Standard Model (SM) of particle physics are much smaller than the Planck energy). The quantum vacuum shares many common properties with topological matter. The goal of the proposal is to concentrate both theoretical and experimental efforts in the investigation of connections between the topological quantum matter and RQV, to enhance understanding of topological condensed-matter systems especially in the ultra-low-temperature regime, and to apply this experience to solution of problems in SM & cosmology. As a condensed-matter system we shall use superfluid phases of liquid 3He – unique topological materials, which are the most close to SM and gravity: Superfluid 3He-A, where the low-energy excitations are topologically protected Weyl fermions, gauge bosons, and gravitons, is similar to the vacuum of SM above the electroweak transition. The fully gapped topological superfluid 3He-B with its Higgs bosons is the counterpart of SM vacuum in its broken symmetry phase. In particular, theory of relaxation of dark energy will be accompanied by experimental study of resonant decay of coherent states of non-equilibrium superfluid vacuum. Determination of the topological classes of the quantum vacua of SM including the vacua with Majorana fermions will be accompanied by experimental studies of Majorana fermions on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combining carbon nanotubes and gold nanorods to investigate the extracellular space around synapses during neuronal communication' (SynECS), addressing dissemination and exploitation.

assistant: **Impact**

The extracellular space (ECS) is a complex network of biomolecules that constitutes a key microenvironment for cellular communication, homeostasis, and clearance of toxic metabolites. In the brain, signalling molecules, neuromodulators, and nutrients transit via the ECS, therefore mediating the communication between cells. To date, understanding the role of the ECS in modulating neuronal communication represents a knowledge frontier in brain research. This limit has conceptual and methodological roots: the complex 3-D dynamical organization of the ECS and the current lack of dedicated relevant investigation tools. The aim of this project is to combine several innovative nanotechnological approaches to reveal the morphological and rheological properties of the brain extracellular space around synapses during neuronal communication processes. To decrypt the intimate interplay between ECS and synapses in neuronal communication, this Action proposes to use innovative optical nanoimaging and nanostimulation methodologies based on nano-probes (single-wall carbon nanotubes, SWCNTs, and gold nanorods, Au NRs). Au NRs will be used to stimulate individual neurons in hippocampal cultured organotypic slices, while SWCNTs will image and unveil the rheological characteristics of the ECS around synapses. The outcomes of this project will bring us a step closer to fully understand chemical-based neural communication and synaptic connectivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Advanced Design Tools for Safety Critical Systems'.

assistant: **Objectives**

SafeAir II will secure the leading edge ASDE (Avionics System Development Environment) tool set and its associated methodology developed in the IST SafeAir 1999-10913 project, while including relevant improved functionalities for end users and demonstrating dramatic cost effectiveness. Beyond SafeAir results, SafeAir II will result in a complete and coherent methodology and development framework to be customised in each industrial company involved in the embedded systems development, to be able to demonstrate the Y life-cycle in secure conditions. The tool kit adoption process will include an evaluation metrics definition as well as its qualification process.The project focuses on the European transport industry as a major domain for embedded systems with exploitation potential in a wide range of European industries with similar challenges.Objectives:SafeAir II is aimed to foster the future adoption of the ASDE methodology in actual real size industrial applications while securing the overall tool set implementation. SafeAir II defines the adaptation process of industrial ASDE exploitation. A methodology for the adaptation process will support the ASDE technology adoption. The connection to industry-standard requirements traceability tools will allow a better integration in the users context, and the automatic test generation will allow subsequent savings in the long run. Modifying the process step by step (from the classical V cycle to the Enhanced Y Cycle) and controlling the result with the preceding step is a major objective of the project. The major reduction in the development effort has to come from a severe cut down of the integration, verification and validation endeavor.Work description:SafeAir II will define and promote an adaptation process that will exploit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'GUIding multi-moDal thErapies against MRD by liquid biopsies -  GUIDE.MRD' in the context of a Horizon Europe call.

assistant: **Objectives**

Advancing personalized approaches in cancer therapy, aiding identification and adaptation of multi-modal treatment strategies for improved outcomes depends on clinical implementation of novel diagnostic technologies. For most cancer types the risk-features used to select individuals for post-operative adjuvant multimodal therapy are suboptimal, where many patients are overtreated and others undertreated. Liquid biopsy has opened a new diagnostic avenue to detect and monitor minimal residual disease (MRD) in individual cancer patients, especially for selecting patients for multi-modal therapies post-operatively. However, despite many circulating tumor DNA (ctDNA) diagnostics being developed there is a lack of standardization, harmonization, and robust data to demonstrate clinical validity. GUIDE.MRD is a consortium of leading academics, technology companies, pharmaceutical companies, and experts in multi-stakeholder engagements. Together, we will tackle the critical questions by developing reference standards for ctDNA diagnostics, clinically validate promising ctDNA diagnostics and develop data to guide the use of multi-modal therapies with a non-invasive diagnostic test. With robust engagement with regulatory authorities, payers and importantly patients themselves, we will develop recommendations and guidelines based on objective data to use ctDNA diagnostics to guide multi-modal therapy selection to improve patient outcomes.


**Keywords:** Circulating tumor DNA (ctDNA), minimal residual disease (MRD), standardization, precision medicine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Dissection of T cell cosignaling and development of vaccination strategies to cytomegalovirus'.

assistant: **Concept**

Cytomegalovirus (CMV, a β-herpesvirus) infects the majority of the world’s population, establishing a lifelong infection. This infection is largely asymptomatic in immune competent hosts, but causes severe disease in immunocompromised neonates and adults. In healthy persistently infected individuals huge numbers of CMV-specific T cells accumulate over time (i.e. “memory inflation”), a process recently associated with the immune risk profile and immune senescence in the elderly. CMV encodes numerous immunomodulatory (or immune-evasion) gene products that target pathways involved in T cell priming and activation, including the regulation of cosignaling molecules such as the B7 molecules. We seek to determine how targeting of these B7 cosignaling systems affects CD4 and CD8 T cell mediated control of MCMV during acute, persistent and latent infection from the virus perspective, using mutant viruses that lack immune evasion genes, as well as from the host perspective by using genetically deficient mice, blocking and stimulating reagents, and adoptive transfers. Additionally, we will investigate the role of other cosignaling molecules (i.e. the stimulating TNFR family members CD27 and OX-40 and the inhibitory CTLA-4 and PD-1 molecules) to determine their precise role during MCMV infection. In this way we will gain more insight in the factors involved in maintaining the delicate balanse between virus and host. Ultimately, we would like to use the obtained knowledge about the role of cosignaling in CMV infection to develop vaccination strategies against (lethal) CMV disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Sensory Emplacement on Trails: An Anthropological Study of Environmental Engagement in Outdoor Endurance Sports'.

assistant: **Concept**

As the climate crisis continues to escalate, engaging the public in meaningful conversations about climate change is more important than ever. To better understand how interactions with natural surroundings inform public participation and environmental engagement, TrailSense examines how participants in outdoor endurance sports—such as trail runners, hikers, and off-road cyclists—interact with their environments. Focused on emplacement and sensory experiences within outdoor endurance sports, TrailSense contributes to climate change discourses by examining and encouraging sustainable relationships with our natural environments. The project is designed to develop my methodological and leadership skills, employing sensory ethnography to examine the multisensory experiences of outdoor endurance participants within the Peak District National Park in the United Kingdom. Utilizing a combination of participant observation and sensation, go-along interviews, in-depth sit-down interviews, and visual anthropology using GoPro recordings and soundscapes, this project will provide rich, qualitative data on how individuals perceive and engage with their surroundings. TrailSense advances the concept of emplacement, emphasizing the importance of emplaced knowledges in promoting environmental sustainability, particularly in relation to trails. By examining the lived experiences of outdoor enthusiasts, the project will reveal the deeper connections people have with natural landscapes. In addition to its research focus, TrailSense embraces science communication and outreach by creating a multisensory installation in collaboration with the Peak District National Park and Trash Free Trails to effectively communicate the research process and its findings to the general public. In enhancing th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Fourth European conference on research infrastructures'.

assistant: **Innovation**

The aim of the proposed activity is to support the organisation of the fourth European Conference on Research Infrastructure (ECRI 2007), which will take place in Hamburg on June 5-6, 2007, under the German Presidency, following the previous successful events in Strasbourg (2000), Trieste (2003) and Nottingham (2005).Overall objectives of the conference are:1. to explore means of structuring and strengthening the European Research Area (ERA) with respect to research infrastructures (RI), and to better coordinate between countries, policies, instruments and funding mechanisms;2. to increase the efficiency of creating new research infrastructures, focusing e.g. on legal and managerial issues, on combination of funding sources, on specific past experiences at European level, taking into account also the social economic impacts of research infrastructures;3. to continue and intensify the exchange of views between decision-makers at international level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Financing systems’ effects on the Quality of Mental health care in Europe' (REFINEMENT).

assistant: **Innovation**

REFINEMENT will conduct the first ever comparative and comprehensive overview of links between the financing of mental health care in Europe and the outcomes of mental health services. Mental health is a key priority area for Europe, as evidenced by the publication by the European Commission in June 2008 of its European Pact on Mental Health and Wellbeing. Conducted across nine European Countries (Italy, Austria, UK, Spain, Finland, Norway, France, Estonia and Romania) it will bring together an experienced team of health economists, mental health service researchers, public health specialists and cover, in term of funding models and interfaces with social care services, a representative range of health care systems across Europe.Four core scientific objectives of REFINEMENT will help us attain our overarching goal of determining how variations in the structure and characteristics of mental health financing systems in nine European states: (1) impact on quality of care; (2) impact on the appropriateness of pathways through the services system; (3) help identify best practice and effective innovations and components of the financing system; and (4) allow us to draw conclusions and present recommendations on how best to structure funding systems in different country contexts. The first objective is to map and describe characteristics (including incentives) of financing systems for mental health care. In objective 2 using detailed descriptions of nine mental health systems, we wish to describe the outcomes of mental health services, including quality of care and met/unmet needs. Objective 3 will describe typical pathways through the health and social care system by people with mental health needs. Finally objective 4 is to build a series of health care financing models cond
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sustainable network for Independent Technical EXpertise of radioactive waste disposal - Interactions and Implementation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The coordination action SITEX-II aims at implementing in practice the activities along with the interaction modes issued by the FP7 program SITEX project (2012-2013), in view of developing an Expertise function network. This network is expected to ensure a sustainable capability of developing and coordinating joint and harmonized activities related to the independent technical expertise in the field of safety of deep geological disposal of radioactive waste. SITEX-II tasks include:– the definition of the Strategic Research Agenda (SRA) based on the common R&D orientations defined by SITEX (2012-2013), the definition of the ToR for the implementation of specific topics from the SRA, and the interaction with IGD-TP and other external entities mandated to implement research on radioactive waste disposal regarding the potential setting up of an European Joint Programming on radioactive waste disposal;– the production of a guidance on the technical review of the safety case at its different phases of development, fostering a common understanding on the interpretation and proper implementation of safety requirements for developing, operating and closing a geological repository and on the verification of compliance with these requirements;– the development of a training module for generalist experts involved in the safety case review process, including the implementation a pilot training session;– the commitment of CS in the definition of the SRA mentioned above, considering the expectations and technical questions to be considered when developing R&D for the purpose of Expertise function. Close interactions between experts conducting the review work will allow enhancing the safety culture of CS and more globally, proposing governance patterns with CS in the framework of geolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evaluation of Prenatal Diagnosis of Congenital Anomalies by Fetal Ultrasonographic Examination' (1994-1998).

assistant: **Innovation**

. To determine how many ultrasound examinations are performed during pregnancy in the European countries, at what stage, by which method. To provide information on European countries having a policy for ultrasound scanning during pregnancy and what is this policy. To evaluate the effectiveness and the efficiency of ultrasound scanning during gestation and its effect on the fetal outcome.Major congenital anomalies occur in 3 % of all newborn. They are becoming the most important cause of perinatal mortality (about a quarter of all perinatal deaths) in the countries of Europe and, after prematurity, the second cause of infant morbidity. Primary and tertiary prevention are at present limited. Regarding secondary prevention research is needed to determine how an optimal provision of prenatal diagnosis and use of services can be achieved. Prenatal diagnosis of chromosomal abnormalities and neonatal screening of metabolic defects are now performed in almost all European countries following well known policies, but they are able to prevent only around three per cent of all congenital anomalies. Therefore other methods of prenatal diagnosis are needed ; among them ultrasound examination of the fetus is now a routine part of antenatal care in many countries in Europe. How many fetal anomalies are actually detected by these procedures ? Registries of congenital anomalies can be used to answer this question. Several benefits can be obtained from ultrasound screening programmes. These are both medical and financial. Informed parents are prepared for problems to come, and appropriate delivery sites can be arranged where necessary. Antenatal diagnosis can reduce the number of postnatal investigations and hopefully, avoid a late clinical presentation. In the case of severe disabling c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Initial Training Network in Nanoscale Semiconductor Spintronics' under Seventh Framework.

assistant: **Concept**

We propose an Initial Training Network for advanced nanoscale semiconductor spintronics. This is a coordinated programme of technological, experimental and theoretical research, training and knowledge transfer, by a consortium of leading European academic and industrial research groups. Spintronics is becoming increasingly important as downscaling and power usage in microelectronics approaches fundamental limits. This ITN will provide a framework for structuring research and training efforts in this field and exploiting the new technology.  The programme will move well beyond the worldwide state-of-the-art, through development of novel multifunctional nanospintronic devices, by transfer of device concepts to room temperature operation, and by exploration of the potential of low-dimensional systems. This coordinated wide-ranging and multidisciplinary programme is only achievable through a cross-European approach.  The ITN will supply the required multidisciplinary and intersectorial training in materials development, device physics and technology and theory, which is crucial for ensuring a highly developed research infrastructure and a critical mass of qualified researchers in this key research area. Researcher mobility will be encouraged, with all appointed fellows spending periods at academic and industrial hosts. Industrial partners will be central to the training programme, ensuring that fellows have an understanding of the needs of end-users of the research. Transferable skills training will be supplied to meet wider employment market needs.   The proposal is highly relevant to the ITN objectives, the Information Society Technologies and Nanotechnologies thematic areas of FP7, and ERA strategies to network centres of excellence, increase researcher mobility, and imp