RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project '2-Dimensional Graphene/MoS2 HeteroStructures as AnodE Compartment of SodIum IoN BattEries' (SEINE), addressing dissemination and exploitation.

assistant: **Impact**

Lithium-ion batteries have been known as the main solution to the global demand for energy storage devices. However, the rising cost and limited availability of Li have hindered the further development of these batteries. Hence, the research paradigm has shifted to develop earth-abundant elements-based rechargeable batteries among which, sodium-ion batteries (SIBs) show promising potential.The main challenge in developing SIBs is to prepare anode material with high capacity and long cycle life. The low cost, versatile synthesis methods, and ample interlayer distance of MoS2 (MS) have attracted researchers to investigate the possibility of using it as the anode section of SIBs. SEINE aims to develop two-dimensional-heterostructures using derivatives of MS and graphene (Gr). While the presence of single-layer Gr with low defect density beneath MS enhances the electrical conductivity compared to pure MS, the formation of dopants and defects on N-doped MS and N-doped Gr (a) forms active sites for Na+ adsorption, (b) modifies the interlayer interactions, (c) affects the Solid-Electrolyte Interface evolution mechanism, and (d) promotes the stability of the anode. Each of these effects will be investigated in depth using different physical and electrochemical characterization methods.We believe that SEINEs outcomes will pave the way to answer fundamental questions regarding the mechanisms which affect the performance of SIBs and hence to develop cost-effective, durable, and high-capacity batteries. Thanks to the experiences obtained in this fellowship, Navid Solati Eskandar will be trained as a scientist with a broad interdisciplinary perspective and expertise in different electrochemical applications. Different steps and tasks of SEINE will be performed via collaboration betw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a lifing methodology for ceramic matrix composites in aero gas turbine engines' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives and content:Cost, performance, weight and emissions requirements for future aero gas turbines require increased temperatures without reducing component reliability. Only ceramic materials can offer a significant increase in material temperature capability in an oxidising environment, and in order to maintain damage tolerance and reliability these need to be used in the form of continuous fibre reinforced ceramic matrix composites.However, introduction of:Such materials into future engine development programs requires good prediction of the component integrity and life to be made before expensive engine tests are performed. Production application requires guaranteed component lives well beyond the experiences, which can be gained in development engines. At present, component lives can only be estimated by crude comparison with fatigue and stress rupture databases. No allowance can be made for progressive damage, multiaxial loading, and thermal cycling. This project is concerned with the identification of design criteria for these materials and the development and validation of a material model to permit the lifting of CMC components in aero gas turbines.The practical objectives of this research project are: Assessment of the life limiting degradation mechanisms under representative service conditions for examples of Oxide and Non-Oxide fibre based CMCs. Generation of a reliable mechanical property database covering representative engine/cyclic lives. Identification of design criteria. Development and validation of a life prediction model.These objectives will be tackled in six interlined tasks: Procurement and characterisation of material. Performance testing. Investigation of deformation and damage mechanisms. Development of a constitutive and lifetime predic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Anti-EGFR Monoclonal Antibody Conjugated Thermoresponsive Liposome for Triple Negative Breast Cancer Thermo-Chemotherapy'.

assistant: **Objectives**

In Europe, breast cancer is by far the most important cause of cancer death among women. In particular, triple negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and associated with poorer prognosis than other breast cancer subtypes. MULTIFUNSOME proposes the use of an anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody-conjugated thermoresponsive liposome to deliver simultaneously an anticancer drug and superparamagnetic iron oxide nanoparticles (SPIO) to TNBC cells for thermo-chemotherapy. We will investigate: 1) the effect of combining anti-EGFR targeting and magnetic hyperthermia (MH) on TNBC in such thermo-chemotherapy and 2) how chemical-physical properties of the SPIOs and liposomes influence the therapeutic activity of the formulation. By conjugating anti-EGFR monoclonal antibody to a liposomal delivery system for targeting, drug and SPIO internalization into EGFR overexpressing TNBC cells will be greatly enhanced. SPIO co-encapsulation in the drug nano-cargo will induce a thermal dose to the TNBC cells when an alternating magnetic field is applied. MH will make TNBC cells more sensitive to chemotherapy and trigger the release of drugs intracellularly by enhancing the lipid membrane permeability. As a result, the effectiveness of chemotherapy could be synergistically enhanced by the concurrent application of MH and chemotherapy. The core size of SPIO will serve as a design parameter that can be readily manipulated to maximize the heating efficient of the multicore SPIO so as to minimize the necessary iron oxide content and maximize the drug encapsulation efficiency. The fellowship program will include a comprehensive training which will help the fellow to develop a unique multidisciplinary expertise. F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Investigation of new genes identified as specific to neisseria meningitidis - a novel approach to study the pathogenesis of meningococcal meningitis'.

assistant: **Innovation**

Introduction Disease caused by Neisseria meningitidis (Nm), remains a serious public health problem worldwide. The molecular mechanisms underlying the pathogenesis of meningococcal meningitis are not fully understood. We addressed this problem by the discovery and investigation of new genes present in Nm but absent from the closely-related gonococcus (N. gonorrhoeae), which does not cause meningitis. Such genes may therefore define the differential pathogenicity of meningococcal disease. Using a genomic subtraction technique we isolated probes for genes which were present in Nm, but absent from N. gonorrhoeae. These genetic differences were found to be grouped in three distinct regions of the chromosome, one of which (about 20 kb in extent) was common to all the strains tested. Aims of the Project This project will investigate this common, Nm-specific region genetically and with respect to the virulence of the meningococcus. This will be achieved by sequencing and mutational analysis of the genes present in this region of DNA. Expected Benefits The information will lead to an understanding of the biological significance of this region of the meningococcal chromosome, and may shed light generally on the pathogenesis of meningitis and the crossing of the blood-brain barrier by bacterial pathogens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'How The Emotions of Politicians Explain their Representative Behavior', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

TEMPER sheds new light on the representative behavior of individual politicians by addressing an overlooked driver of that behavior: their emotions. What makes politicians decide to be responsive to public opinion signals at some occasions, but not at others? And how do politicians go about communicating their viewpoints, sometimes using very emotional or uncivil language, and at other times not? Whereas extant research has been preoccupied with studying the cognitive, strategic reasons that politicians may have to act so-or-so, TEMPER focuses on the emotional explanations of their behavior. It sketches a portrait of politicians who are, above everything, human.Doing so, TEMPER bridges the gap between theories of elite behavior and theories of the political behavior of citizens, which have—relying on insights from psychology—taken an ‘emotional turn’ decades ago. As emotions arise in response to concrete situations of signals, TEMPER pays attention to the situations or signals that provoke politicians to communicate and act. Its objectives are to explain (1) how characteristics of situations or signals elicit emotions in politicians, (2) how these emotions influence their subsequent representative behavior, and (3) how the resulting ‘emotional explanation’ of behavior maps onto existing (mostly cognitive) explanations of behavior.TEMPER studies the emotions of politicians directly, in a series of (1) survey-experiments with politicians; (2) interviews with politicians; and (3) direct observations of actual media debates and party meetings. It combines self-reported measures of emotion with psychophysiological measures of affect, which are less susceptible to rationalization and social desirability. The findings of TEMPER will reveal how patterns that we currently interp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Neurotrophic factors in Parkinson's and Huntington's disease models : A gene therapy approach' (1994-1998).

assistant: **Innovation**

Determine new possible functions of the neurotrophins, GDNF and Eph-ligands.Examine whether these factors are able to prevent or compensate the degeneration of neurons in animal models of Parkinson' s or Huntington' s diseases.Establish the basis for the development of a gene therapy approach for Parkinson' s and Huntington' s diseases, based on the grafting of neural progenitor cells expressing neurotrophic factors or on the direct administration of neurotrophic factors genes.The present project covers the following topics:Characterization of the role of the neurotrophins, GDNF and Eph-ligands on the survival and phenotype of embryonic neurons from the substantia nigra, locus coeruleus, raphe and striatum in culture.Study of the role of the neurotrophins, GDNF and Eph-ligands in vivo, both during the postnatal development and in the adult. This will be done in three steps: a) Establishment of cell lines expressing high levels of Eph-ligands (NGF, BDNF, NT3, NT4/5 and GDNF cell lines are currently available). b) Characterization of the levels of expression of neurotrophic factors and their receptors in lesion models of Parkinson' s and Huntington' s diseases. c) Assessment of: the neurotrophic action of the cell lines in the intact brain, the protective effect of the factors on neurons in the lesion models, and the induction of compensatory responses in neurons after the lesion, including hypertrophy, sprouting or induction of specific enzymatic activities.Investigate the function of these neurotrophic factors in mice with targeted deletions of the neurotrophin or trk genes. Possible alterations in the neurons of substantia nigra, locus coeruleus, raphe and striatum or in the innervation of their targets will be evaluated. Cell lines expressing neurotrophic factors will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electric-field driven magnetic domain wall motion for memory technologies' under Horizon 2020.

assistant: **Concept**

Memory technologies that are used in computers, smart phones, tablets, etc. can be coarsely divided into two classes: fast but volatile DRAMs (dynamic random access memory) and non-volatile flash memories. Racetrack memory based on the controlled motion of magnetic domain walls is a promising new technology for next generation memories, because it combines the speed of DRAMs and the non-volatile properties of flash memories. One key drawback, however, is the required use of intense electric currents to move magnetic domain walls along narrow wires, which causes undesirable heat dissipation and considerable power losses. With this ERC proof-of-concept proposal, we aim at exploring the empty technology space around a recent invention in our laboratory, namely the ability to drive magnetic domain walls using electric fields (i.e. voltages) rather than electric currents in ferroelectric-ferromagnetic bilayers. Since no electric currents are flowing through the insulating ferroelectric layer during prototype device operation, power consumption and heating are minimal. Moreover, electric-field control of magnetic domain wall motion in our experimental demonstrator is deterministic and completely reversible. Using the ERC proof-of-concept grant, time and money will be invested for obtaining IPR protection for this new technology, different ways for industrial collaboration will be investigated (e.g. licensing of the technology/IPR directly or founding of a technology licensing spin-out) and contacts will be sought. A market analysis will be performed and a commercialisation roadmap and IPR strategy will be created.


**Keywords:** Nanotechnology, magnetic memory, electric-field controlled magnetism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ALL ELECTRIC SUBSEA OIL PRODUCTION SYSTEM [STAGE 2]' (AESOP), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the project is to undertake in two stages the manufacture and demonstration of the Aesop All Electric Subsea Oil Processing System. Stage 1 will consist of Engineering design and Manufacture, Stage 2 will conclude with Assembly Testing and Demonstration. The oil industry is traditionnally conservative with regard to new technology and therefore the demonstration of the System is necessary to facilitate the commercial exploitation of the technology by proving its technical viability and reliability. The objective is to move towards a first oilfield application of the system through close involvement with oil company operators throughout the project, tailoring the test procedures to suit both the operators and certifying authorities.L%This reporting period is characterised by Hardy Oil & Gas buying equity in the new Alpha Thames Ltd and signing an agreement with two of Halliburton's business units, Halliburton Energy Development and Brown & Root Energy Services to deploy AlphaPrime technology on a worldwide basis. On the basis of initial information, Hardy's PY-3 field was chosen for AESOP development but the field proved to be commercially (and technically) unsuitable for testing the prototype AESOP. At the AESOP JIP meeting at Kockums on 8th July 1998, it was agreed that the first AESOP module be designed as a demonstration unit and would be tested and demonstrated using Kockums'ship lift facility. Meanwhile, potential offshore fields are being studied and marketing activities continue.The Aesop System is a complete subsea processing system with significant innovation in all areas: All Electric Power and Control - AESOP uses electricity as the common source for both motive power and control thereby reducing cabling and connection requirements. The removal of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'miRNA regulation of developmental sodium channel isoform transition and its implications for Dravet syndrome' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Dravet syndrome (DS) is a rare epileptic encephalopathy affecting ~1:20000 children, who suffer from infantile seizures and lifelong deficits in cognitive, motor, behavioural, and social skills. DS can cause premature mortality with up to 21% of patients not reaching adulthood. Despite the known genetic origin – 80% of patients carry a mutation in the SCN1A gene encoding the alpha1 subunit of the sodium voltage gated channel – there is no cure for this disease. The symptoms of DS start at ~ six months of age, shortly after the transition from the developmental Nav1.3 (SCN3A gene) to the postnatal Nav1.1 (SCN1A) channel isoform carrying the mutation. The mechanism of this transition remains unexplained, which hinders the Nav1.3 isoform-based DS therapy. I will build upon the recently discovered miRNAs’ (short, non-coding RNA) regulatory effect on SCN1A and 3A genes to elucidate regulation of the isoform transition. My ULTIMATE AIM is to harness the protective effect of the Nav1.3 isoform via miRNA regulation as a DS treatment. I will untangle the miRNA profile of DS from birth to the symptom onset in a well-established mouse model. Through miRNA expression manipulation, I will resolve miRNA function in SCN1A and 3A regulation, its impact on the brain, and ultimately on DS symptoms. My skills in developmental epilepsy models will combine with Prof Henshall’s expertise in miRNA function and use in treatment (shown by miRNA-based treatments for epilepsy in pre-clinical development) to deliver novel treatment options for devastating DS and advance the field of miRNA regulation in the brain. This training & collaboration with top neurobiologists at three excellent institutions – RCSI (host), UA & UMCU (secondment partners) – will advance my skills & employability and propel m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The most advanced micromotors in the world'.

assistant: **Objectives**

Micromotors are ubiquitous, used in your electric toothbrush, in your dentist’s drill and in modern industrial robots. The most important component that determines motor performance, functionality and longevity, is the copper winding, which dictates how much power a motor can generate for a given current. The way these copper windings are produced has not changed much over the last 40 years: they are either wound by hand for prototyping or for small production runs, or they are produced by expensive machines that are complex to operate, inflexible and viable only for large production runs. Mirmex is transforming the way micromotor windings are produced: instead of winding copper wire by hand, Mirmex prints them on PCB’s before rolling them with high precision. This approach to producing windings has many user benefits: motors are easier and less costly to prototype, they are more flexible in design terms, more durable, lighter, become hot less quickly, feature higher torque and greater dynamics - and all at a lower cost than the incumbent technologies. The go-to-market strategy will focus initially on the surgical/dental power tools segments because they care more about performance, weight and other value-added features than about price. Mirmex will then address the industrial/automotive sector and begin producing motors, in addition to windings. Demand is already strong: Mirmex has received purchase orders worth €80k for small quantities of prototype products and 8 LOIs. In order to fully exploit the very high commercial potential of our innovation, Mirmex needs to demonstrate that (i) it is able to manufacture windings of exceptional quality in commercial volume, (ii) the products meet the stringent requirements for autoclavability from medical customers and (iii) our