RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Engineering of low germination stimulant production to control witchweed infection in maize in Sub-Saharan Africa' in the context of a Horizon Europe call.

assistant: **Objectives**

The parasitic witchweeds, such as Striga hermonthica and Striga asiatica, pose an enormous threat for production of cereal crops, such as sorghum, millet and maize, in the African continent, threatening the livelihood of millions of people, especially in sub-Saharan Africa. Striga seeds lay dormant in the soil until their germination is triggered by strigolactones (SLs), signaling compounds exuded by roots of plants, including maize. Maize exudes at least six different SLs from its roots into the rhizosphere, two of which were structurally identified as zealactone and zeapyranolactone.In work on maize strigolactone biosynthesis that was part of the ERC Advanced grant CHEMCOMRHIZO we demonstrated that there is natural variation in the germination stimulant composition in the root exudate of maize varieties and that this results in a degree of Striga resistance. We have elucidated the entire biosynthetic pathway of all SLs in maize and we showed that the difference in strigolactone composition is the result of a difference in the expression of one of the genes in the pathway. The line with the strongest reduction in the expression of this gene, a North-American cultivar, displays almost full Striga resistance compared with a susceptible control. In collaboration with the CGIAR institute CIMMYT, we propose to create knock-out lines in this gene in two elite African maize varieties to deliver the proof-of-concept that this Striga resistance can be introduced into Africa.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of peptidoglycan in bacterial cell physiology: from bacterial shape to host-microbe interactions' under Seventh Framework.

assistant: **Concept**

Peptidoglycan (PGN) is a major essential and unique component of the cell wall of both of Gram-negative and Gram-positive bacteria. Because of the central role of PGN metabolism in bacterial cell structure and shape, in antibiotic resistance and in host-microbe interactions, any process affecting one of these aspects has direct consequence on the other two. Hence, the study of PGN metabolism is of seminal importance for a better understanding of bacteria in their environment. My project is centered on these three major aspects of PGN metabolism using several bacterial models. The project can be divided in two parts, one aimed at studying PGN metabolism to better understand how bacteria assemble a mature PGN that confers rigidity and shape to the cell despite a highly dynamic process to accompany cell growth and division (Part A). I propose to continue using Helicobacter pylori as a bacterial model since genome analysis indicates a minimal set of genes involved in PGN metabolism and assembly suggesting it might be a simpler model to study PGN metabolism. By characterizing the role of H. pylori PGN synthetases and hydrolases, my aim is to better understand PGN metabolism and to develop new therapeutic/antimicrobial strategies. The second part of my research project (Part B) is aimed at studying the role of PGN in host-microbe interactions and its detection by the recently identified intracellular receptors Nod1 and Nod2. Using several bacterial models, the objective is to understand how pathogens are able to subvert/modulate the host response by modifying their PGN. The different models include Helicobacter pylori, Neisseria meningitidis, Yersinia sp., Listeria monocytogenes among others. A second objective is to understand the dynamics of PGN sensing in the host cell dur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Romanian Research Community Integration in the European Research Area' in the context of a Sixth Framework call.

assistant: **Objectives**

ROINTERA Specific Support Actions will be implemented to stimulate, encourage and facilitate the participationof organizations from Romania in the activities of both priority thematic areas and cross-actions of FP6. These willcomprise information, awareness and training activities, promotion of the competencies of the Romanian researchcommunity, support, mainly, to researchers from Romania, but also from other EU and AC countries to participatein conferences in Romania and to prepare common proposals, establishment and reinforcement of networks of highquality research centres in Romania in order to improve the co-operation with similar centres from Member Statesand other ACC.ROINTERA project will cover three out of four issues presented in the Annex D 1- General Call of the Work progrmme:- Network the NCPs (National Contact Persons)- Network high quality centres of research- Organise information events.The ROINTERA project has 5 work packages (WPs):The goal of the WP 1 is to create a virtual network involving all of these people, but also, by this, to improve theirmutual co-operation, as well as the distribution of the FP6 related information within Romania and the distributionof the Romanian R&D related information to the Member States and ACC.The goal of the WP 2 is to network high quality centres of research and to support the operation of these networksin the specific scientific fields, including the priority thematic areas.The goal of the WP 3 is the organization of three annual national general information events to present the work programmes of the Sixth Framework Programme and the contents of the calls for proposal.The goal of the WP 4 is devoted to the design, development and implementation of the ROINTERA one stop shop" information system.The WP 5 is devoted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Australian/Chinese connections in the world city network: specification, modelling, and EU implications""' in the context of a Seventh Framework call.

assistant: **Objectives**

The overall scientific objective of this IOF research training project is to examine recent world city network (WCN) evolutions, with a specific focus on (i) how for Australia’s leading cites (Sydney and Melbourne in particular) this evolution is being driven and shaped by the booming economies/connectivities of China’s leading cities (Shanghai, Beijing and Hong Kong in particular) and (ii) the wider implications of the latter for Europe’s major metropolises.The methodological context is a model developed by the leading research group in this field, i.e. the Globalization and World Cities (GaWC) network, of which the applicant has recently become an associate director. The proposed IOF research training project will continue to draw on this GaWC model and the standard techniques for investigating the resulting datasets, but it will also seek to tease out two novel methodological approaches for understanding (evolutions in) the WCN. These novel methodologies will (i) concentrate on devising more detailed analyses of individual inter-city links and (ii) focus on ways to link up the fast-evolving WCN literature with the established literature on (the evolution of) social networks. In addition, the project will also entail a sizable research management component.The project’s EU host is Ghent University (Belgium), the third country host is Monash University (Australia). The choice for Monash University is based on unique combination of top-drawer research schools in tangible research domains which together sustain the ideal environment for carrying out the proposed research project. The project’s EU dimension is further secured through the presence of a prestigious European Union Research Centre at Monash University.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Large area pixelized intelligent" digital sensors for nuclear imaging in medical & industry: single crystalline cdte/cdznte, thick pixel detectors, integrated electronics, assembly in a modular set up and nuclear medecine demonstration ins"' to be submitted under Fifth Framework.

assistant: **Abstract**

Worldwide, digital imaging for nuclear medicine and industrial NDT testing is under development. For Europe is of great importance to have access to both the semi- conductor materials, sensors and I.C. electronics which constitute the key parts of this new technology. This project has in mind over the 36 months workprogramme to fulfill these needs: large area (50.0mm indiam.) Cadmium Telluride and Cadmium Zinc Tel- lurdie SINGLE CRYSTALS, new very thick INTEGRATED PIXEL DETECTORS, made from these semi-insulating crystals (new interpretation ramo theorem + single charge collection) I.C. multichannel low noise chip; hybrid modular assembly, with all connectors. Application in a nuclear medicine demonstrator, to demonstrate the image quality improvements due to pixel effect and strong dose reduction to the patient.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Ethics of Synthetic Data in the Age of Machine Learning and AI' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

SYNDATA develops a novel approach to understanding the ethical consequences of synthetic data for contemporary societies. Machine learning algorithms and AI models such as Gemini and GPT-4 are increasingly used to generate data (called ‘synthetic data’), which is in turn used to train other algorithmic models. This is leading to transformations in social and political life, because synthetic data embody a promise to address an array of ethical challenges associated with AI, such as the lack of ethnic diversity and gender representation in large training datasets, in addition to issues of privacy and confidentiality in sensitive datasets. In short, if some data cannot be collected in the real world, it can be generated via algorithms. This is particularly relevant in societal domains – such as healthcare, finance, and government – where an ethical question in the use of sensitive personal data is common. While there is a substantive literature outlining the various effects of data and algorithms on society, the area of synthetic data remains both under-researched and under-theorised. As such, SYNDATA will pioneer the first large-scale, systematic social science study of synthetic data. By examining the three pressing issues of generativity, representation, and resistance, the project will take seriously the ways that synthetic data are generated whilst also transforming how contemporary algorithms and AI models are trained and deployed in society. In order to do this, the project will conduct both archival research into the historical antecedents of synthetic data as well as path-defining studies of different areas where synthetic data is currently being generated and deployed as a way to train algorithmic systems: biometrics and facial recognition as well as weapons amm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Adaptation of microbial communities to organic contaminants in oligotrophic aquifers'.

assistant: **Objectives**

To explore the diversity, degradation capacity and resilience of the poorly known microbial communities in pristine and polluted subsurface aquifers, a comparison will be made between a set of logographic communities before and after exposure to a plume of pollutants. A combination of culture-dependent and -independent methods will reveal the functional and genetic characteristics of the communities involved in degradation of a selected range of contaminants (BTEX components) of the chosen aquifer. A detailed study of the genetic and physiological diversity, metabolic potential and adaptability in laboratory-scale model systems will demonstrate how the potential and performance of such communities may be optimised. This will eventually allow experimental manipulation of in-sit enhancement of bioremediation processes by making a rational use of the microbial diversity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Genetic analysis of the transcription factor tfiid subunit tafii28'.

assistant: **Objectives**

Research objectives and content Despite a wealth of data coming from in vitro transcription and transfection experiments the role of TFIID subunits (TAFIIs in trancriptional regulation in mammalian cells has not been strictly defined. I propose to use mammalian genetic techniques to address this question. Previous studies have implicated TAFII28 as a cell-specific TAFlI involved in transcriptional regulation by nuclear receptors. I will determine the mRNA and protein expression pattern of TAFII28 in established cell lines and in the developing and adult mouse. According to the results of this study, I will use the technique of conditional cre/lox mediated homologous recombination to inactivate TAFII28 either in F9 embryonal carcinoma cells or in ES cells allowing the generation of TAFII28 null mice. The phenotype of the resulting TAFII28 null F9 cells and/or mice will be characterised. Training content (objective, benefit and expected impact) The research I propose will enable me to learn important genetic techniques for the study of genes in mammalian cells and techniques in biochemistry. At the IGBMC I will gain important experience in the field of transcriptional regulation, embryology, and in the biology of nuclear receptors. The proposed research entails the use of homologous recombination in F9 cells, a procedure in which the IGBMC has considerable experience. I consider that the opportunity to learn these techniques at an outstanding institute such as the IGBMC is fundamental for my research carreer. Links with industry / industrial relevance (22) None
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DEliberative CItizens' DEbates in European science centres and museums' (DECIDE).

assistant: **Innovation**

DECIDE will raise awareness and understanding of deliberative democracy methods, produce a tool to conduct and facilitate deliberative consultations and monitor the change of attitudes among the European public on contemporary Life Sciences.It will produce a kit" to facilitate structured debates on controversial issues (stem cells, cloning, GMO, genetic property rights etc.) in many science centres and museums across Europe. The topics will have a direct link to current policy discussions. The kit includes a series of "cards" representing facts,issues, policies and scenarios (participants will be able add their own arguments as required) that help participants to visualize the debate on a discussion board and reach consensus. All materials will be translated in the languages of the countries where the meetings will take place. DECIDE will directly engage a very diverse audience of more than 2000 adult and young citizens in several countries via the European network of science museums and other institutions. All the products developed by DECIDE will be evaluated and made available for free to everybody. The results of the meetings will be published on the Internet, making it possible to see how different groups react to discussions about particular life science issues. DECIDE will rely on an international scientific advisory board during the whole project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Advanced clinical photoacoustic imaging systems based on optical microresonator detection'.

assistant: **Concept**

Photoacoustic imaging is widely viewed as one of the most exciting and promising biomedical imaging techniques to have emerged in recent years. It offers major opportunities for increasing our understanding of basic biological processes at an anatomical, physiological and molecular level, and for improving the clinical diagnosis and treatment of cancer and other major diseases. The aim of this project is to develop and evaluate a new generation of advanced photoacoustic scanners for clinical photoacoustic imaging based on a novel, highly sensitive, optical microresonator ultrasound sensor. This type of sensor offers the prospect of a major step forward in terms of imaging performance by providing orders of magnitude higher sensitivity than equivalently sized conventional detectors with the necessary broadband frequency response and small element size for high image quality. As a consequence, it promises greater penetration depth and improved image quality than possible with current state-of-the-art photoacoustic scanners. This will pave the way for in vivo high resolution human imaging at depths currently unattainable, opening up entirely new clinical applications in oncology, cardiovascular medicine, regenerative medicine and other areas which have hitherto been impossible due to hardware limitations. The project will involve the development of novel polymer optical microresonator sensors, advanced parallelised optical read-out schemes for real-time image acquisition, and engineering complete imaging instruments for use in clinical studies. These instruments will then be evaluated in a variety of clinical contexts including the assessment of skin cancer, head and neck cancers, cardiovascular disease and reconstructive surgery.


**Keywords:** Photoacoustic, optoacousti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Artificial Photosynthetic Stomatocyte for Intelligent Movement' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The discovery of first centimeter-sized chemical motors has brought great interest in the field of catalytic micro/nanomotors fabrication. By harnessing chemical energy from active fuels, nanomotors with long-range and sustainable movement have been achieved, promising their biomedical application. However, the potential side effect of active fuels and limited motion control still constrain the nanomotor field. Using biocompatible and abundant water as fuel to drive intelligent movement will enable an ideal nanomotor. The goal of this proposal is to exploit artificial photosynthetic water splitting to drive intelligent movement of stomatocyte nanomotor by taking inspiration from thylakoid, which has not been explored before. The highlight of this proposal is the compartmentalized immobilization of natural most efficient water oxidation catalyst, photosystem II and artificial metal-free water reduction catalyst, nitrogen-doped graphene quantum dots on stomatocyte nanomotor to drive translational and rotational motion by catalysing artificial photosynthetic water splitting. Motion speed and direction can be individually controlled for intelligent movement by regulating the translational and rotational motion. Solar energy is simultaneously converted into chemical and kinetic energy by the artificial photosynthetic stomatocyte nanomotor. This design will be a paradigm shift for future nanomotor development with controlled attributes driven by biocompatible resources, and artificial photosynthetic system development with high efficiency. The project clearly links to Marie Skłodowska-Curie Individual Fellowships work programme, which will diversify my individual competence in terms of skill acquisition through advanced training and international mobility together with strong