RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mimicking organs on chips for high throughput drug screening and basic research' (MIMIC), addressing dissemination and exploitation.

assistant: **Impact**

MIMIC is an interdisciplinary European Industrial Doctorate at the interface of cell biology, engineering and drug development. MIMIC aims to develop and improve novel “organs on chips” technology. This technology combines modern cell biology with microfluidics and chip-based techniques with the goal to mimic organ functionality. There is a high demand by the pharmaceutical industry for more reliable tissue models to test drug toxicity and drug efficiency at early stages of drug development. Early reliable drug testing will have a major impact on drug development costs and human health. Furthermore, ethical considerations urge for the search for alternatives to replace animal tests in drug development and basic research. Organs on chips are a new exciting possibility to closer mimic human organ functionality in vitro than conventional 2D or 3D cell cultures.Organs on chips allow both, the emulation of healthy organs as well as the emulation of specific disease conditions using corresponding engineered or patient derived human cells. Moreover, organs on chips are ideally suited for high-throughput drug screening. The EID-MIMIC will develop novel organs on chips prototypes, and validate their suitability for end-users for high throughput drug screening or basic research. MIMIC will train early stage researchers in cutting edge technologies, like novel chip based technologies e.g. cell micropatterning, soft-lithography and microfluidics technology, as well as state of the art microscopy like super resolution- and confocal spinning disc microscopy and modern genome editing techniques like CRISPR-technology. In addition, MIMIC has developed a 3 year modular curriculum including workshops on creativity and business skills, summer schools, business plan competitions and intern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New low impact cross-linkers to adoptin leather finishing technology' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives (recapitulation):The technical control of the efficiency and performance of the new crosslinkers, in combination with different binders; the development of a low impact efficient cross-linker system that can be adapted to different types of leather; the screening of application properties at a semi-industrial scale; the improvement of the quality of the sprayed leather through an extensive analysis of its characteristics; the determination of the toxicological properties of the new selected productsScientific achievements:Study of the filming properties and characterisation of the system cross-linkers-binders for 2 new cross-linkers at different weight ratio with respect to the binder; overview of aziridin toxicology and comparison with the new crosslinkers'; screening of application properties and ideal recipes for the new crosslinkers; finished samples of leather for different articlesSocio-economic relevance and policy implications:The relevance of the work performed at this level is high as it can bring to a substantial reduction of the health and safety potential problems of the tannery finishing workers and to the improvement of the health quality at the workplace through a lower danger of contamination of workers with hazardous spray mist and of skin contamination. More, it can bring to the end of use of aziridinic compound in the leather sector, raising the level of risk knowledge of the workers in tanneries. The early compliance with more severe legislation for hazardous substances to be issued in the future is another important point to stimulate the European leather sector to work towards an improvement of working conditions and a lowering of the environmental impactConclusions:The project can be considered extremely successful, more for the politi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Dark energy Analysis for W and Next-generation Surveys'.

assistant: **Objectives**

Type Ia Supernovae (SNe Ia) remain unparalleled probes of astronomical distances and provide crucial constraints when measuring the properties of dark energy. But recent cosmological analyses with SNe Ia have pushed the boundaries of our physical understanding of these standardisable candles. The largest source of cosmological systematic uncertainty for SNe Ia is the impact of astrophysical effects from both extrinsic host galaxy properties (such as dust content) and the intrinsic effects of the SN. Without better understanding how SNe Ia interact with, and are co-dependent on, their host environment, the key cosmology programs of future surveys, such as the legacy survey of space and time (LSST) from the Rubin Observatory, will not reach their goals.My MCSA Fellowship will make use of a new high-quality sample of 3,000 SNe Ia and their hosts taken from the Zwicky Transient Facility (ZTF) and the internationally-recognised expertise of the host, the University of Southampton. I will use this as a basis to better understand SNe Ia for use in cosmology and in astrophysics. I will create a catalogue of the host galaxies with high-quality measurements across the electromagnetic spectrum, providing global and local measurements of galaxy properties to probe how they impact SNe Ia. Then, I will use integral field spectroscopy of local SN hosts to provide hyper-local measurements at the site of the SN Ia explosion, augmenting the statistics of the host galaxy catalogue with in-depth measurements. These two work packages will then be combined to assess the impact of these host galaxy effects on cosmology, determining which galaxy evolution processes drive the observed correlations of SN Ia brightness, and the ideal tracer to use for the high-statistics cosmology analyses of Rub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Vascular antibody-mediated pharmaceutically induced tumour resection' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The most significant advance in cancer therapeutics in recent years has been the introduction of monoclonal antibodies into widespread clinical usage. A consequence of this rapid emergence of antibodies as therapeutics is a lack of trained scientists within the EU with the requisite skills to enable antibody development at a globally competitive pace. The University of Birmingham (UoB) together with the SME SomantiX (SOM) aims to address this need by training the next generation of scientists with the appropriate skills. Together with seven associated partners, we have created an intersectorial EID proposal titled “Vascular-Antibody Mediated Pharmaceutically Induced tumour REsection” or VAMPIRE. The primary aim of the proposal is to train 5 early stage researchers while conducting an internationally competitive oncology research project. VAMPIRE will provide training across a wide range of disciplines involved in the production of antibodies and in their evaluation as therapeutics in animal models of cancer. Training will be provided through an integrated partnership involving all of the partners in the consortium ensuring interdisciplinary and intersectoral experience for the ESRs. The antibodies that we aim to develop will target markers of the tumour vasculature that we have identified previously, including CLEC14A. The commercial partner SOM is a Dutch SME specialized in the development of tumour vascular targeting agents. The findings of this project will be of interest to cancer research and the wider public community. Intellectual property generated by the project is envisioned to be licensed to SOM.  Pre-clinical development of the antibodies is envisioned to be carried out via strategic alliances with academic partners and other small biotechnology companies. W
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Seed propagation of indigenous species and their use for restoration of eroded areas in the Alps' in the context of a Fourth Framework call.

assistant: **Objectives**

More than 11 million people live within the 180.000 km2 large alpine area. 7 nations, 43 regions and 5.800 communities have part of it. Erosion is a basic problem found in the entire alpine area. Due to development in the Alps in recent decades, thousands of hectares of land in high altitudes have been affected by ski-slopes, lifts, tourists infrastructure, roads, improvements of alpine pastures, power stations as well as protective measures against avalanches. According to the latest estimates 5.000 hectares have to be restored yearly, more than 50.000 hectares of already restored areas need imperative improvement. In addition to this, natural erosion causes increasingly more problems. All of these factors are pose serious threats to the valley inhabitants (floods, bed material load to the valleys etc.). The present used cheap but unsuitable commercial lowland species are bred for grassland or lawn areas in lowland regions. They are not adjusted to those areas, their use leads to unsatisfactory results. The resulting ecological and economical damage is considerable: flora falsification, degradation of the vegetation, soil erosion, damage to the countryside, enormous costs for repairs, frequent reseeding, constant fertilising, maintenance. The use of seed mixtures of indigenous subalpine and alpine species (produced by farmers) in combination with improved application techniques, would help to avoid all those problems and will lead to a new state of the art in restoration of damaged areas in high altitudes. The successful large scale propagation of these species will be basis for a lucrative production-niche to thousands of farmers. The potential area for cultivation of indigenous species is estimated on 12.000-15.000 hectare. The participating scientific institutes hav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of environmentally-friendly Bio-sources aerogel as the support Core for vacuum insulation panels (VIPs)' (VIPs), addressing dissemination and exploitation.

assistant: **Impact**

This Marie Sklodowska Curie Individual Fellowship will bring an outstanding experienced researcher to work in Europe and be mentored by a world leading expert in low energy building technologies. Over the past 20 years, the Incoming Research Fellow, Prof Fatang Jiang has specialised in biodegradable materials and been an active technology entrepreneur by successfully commercialising his research outcomes including polysaccharide sponges and aerogels, edible desiccants, biodegradable and structure controllable superabsorbents for water retention, and innovative water activity measurement. The proposed project has been carefully chosen to match the researcher's experience in bio-sources materials with the host scientists’ expertise in low energy building technologies to produce some innovative outcomes and create new benefits to the society in Europe. The project aims to develop an environmentally-friendly bio-sources aerogel as the support core for vacuum insulation panels (BioCore VIP). Thermal insulation is a primary approach to reduce the buildings’ energy demand. Aerogel, particularly encapsulated in vacuum panel with a multilayer film, is a super insulation material with an extremely low thermal conductivity and hence can obtain the required thermal resistance with a very small thickness, which is desirable commercially in order to minimise the effect of insulation on the building usable space. Development of the proposed aerogel requires comprehensive scientific knowledge including material preparation, freeze-drying, heat transfer and buildings’ energy analysis. Combination of the expertise between the Incoming Researcher and the host team matches this requirement perfectly. In addition to the scientific goals, the Incoming Researcher will contribute his expertise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Trait gene mapping in a cross between two divergent pig breeds - duroc and mangalica' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Foreseen ResultsThus, this project is aimed at moving from the low resolution mapping of QTLs through the high resolution mapping of these QTLs and towards the identification of the genes involved and the specific molecular variant within the gene causing the genetic variation. As knowledge of the molecular basis of QTL action is limited information produced in this project could have a significant influence of quantitative genetic theory and on future breeding programs. Our strategy is to focus of QTLs with the largest effect in a cross between two genetically divergent breeds - the Mangalica (or Hungarian lard) and the Duroc which is renowned for its meat quality - in order to maximize our precision in mapping the QTLs and hence our chance of ultimately cloning one or more of them. We will largely use the positional candidate gene approach, and having mapped the QTLs with high precision we will map candidate genes to the region from an adipose tissue cDNA library as well as mapping potential candidate genes which should map to the region on the basis of their map positions in other species, particularly man and the mouse. Strong candidates (on the basis of position and function) for the QTL effects in the pig will be explored thoroughly.The project objectives are fully consistent with area 9.1 on Genome mapping and improvement of farm animal selection" in the INCO COPERNICUS work program as they concern the use of established genetic maps for QTL analysis in relation to improving the quality of production.This project concerns the mapping of genes of economic importance in pigs and in particular those genes influencing fatness. Reduced carcass fatness brings benefits in both improved carcass quality and efficiency of production. However, reducing overall fatness also
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ESTIMATION AND CONTROL FOR SAFE WIRELESS HIGH MOBILITY COOPERATIVE INDUSTRIAL SYSTEMS' (EC-SAFEMOBIL), addressing dissemination and exploitation.

assistant: **Impact**

Autonomous systems and unmanned aerial vehicles (UAVs), can play an important role in many applications including disaster management, and the monitoring and measurement of events, such as the volcano ash cloud of April 2010. Currently, many missions cannot be accomplished or imply a high level of risk for the people involved (pilots and drivers), as unmanned vehicles are not available or not permitted. This also applies to search and rescue missions, particularly in stormy conditions, where pilots need to risk their lives. These missions could be performed or facilitated by using autonomous helicopters with accurate positioning and the ability to land on mobile platforms such as ship decks. These applications strongly depend on the UAV reliability to react in a predictable and controllable manner in spite of perturbations, such as wind gusts.On the other hand, the cooperation, coordination and traffic control of many mobile entities are relevant issues for applications such as automation of industrial warehousing, surveillance by using aerial and ground vehicles, and transportation systems.EC-SAFEMOBIL is devoted to the development of sufficiently accurate common motion estimation and control methods and technologies in order to reach levels of reliability and safety to facilitate unmanned vehicle deploymentin a broad range of applications. It also includes the development of a secure architecture and the middleware to support the implementation. Two different kinds of applications are included in the project:<br/>-\tVery accurate coupled motion control of two mobile entities. The technologies will be demonstrated in two challenging applications dealing with the landing on mobile platforms and launching of unmanned aerial vehicles from a manned vehicle.<br/>-\tDistribu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Noninvasive Manipulation of Gating in Ion Channels' in the context of a Horizon 2020 call.

assistant: **Objectives**

noMAGIC has the visionary goal of engineering genetically encoded ion channels, which can be remotely controlled (gated) by stimuli that penetrate deep into human tissue without negative side effects. The control over ion channel activity by deep penetrating stimuli will revolutionize research in neurobiology and physiology as it paves the way for remote and genuine non-invasive control of cell activity in vivo. Synthetic channels, which can be gated by magnetic fields (MF), near infrared (NIR) radiation or ultrasound (US) will be engineered in the frame of noMAGIC by three complementary work packages (WP1-3). Design and engineering of the channels will be performed in WP1 by reiterated steps of rational and irrational design, high throughput screening and in vitro and in vivo functional testing. We have identified two sensor modules for MF and NIR radiation, respectively, which will be functionally connected to a channel pore for a remote control of gating. For the US-gated channel we will engineer a channel pore that is maximally responding to local changes in the lipid environment induced by US. Design and engineering of channels will be complemented by a computational approach (WP2), which analyses, from elastic network models, the mechanical connections in the channel pore and which extracts information on the forces, which are required to gate a channel by the three stimuli. The outcome of WP2 will provide general design rules for synthetic channels with implications much beyond the present project. WP3 also contributes to the engineering effort in WP1 by a spectrum of avant-garde spectroscopic methods, which resolve structural changes of the channel proteins under the influence of remote stimuli. These structural insights will greatly advance our understanding of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Self-replicating Colloidal Assemblies' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Self-replication is the preeminent property of living systems and natural materials. Nature builds and repairs by self-replication. Purely synthetic materials so far lack this important ability. An indispensable prerequisite is the multi-directional control of interactions between the building blocks of materials. In order to generate colloidal building blocks, which are able to self-replicate in a non-biological two-step process, i.e. without the use of DNA, we propose to create a new class of patchy colloidal particles bearing three patches of two different chemical functionalities. The new production process will yield precise control over the patch location and chemistry and thus also gives particles that go well beyond known ABA- or ABC-type Janus particles. For synthesis and replication of colloidal superstructures (e.g. particle strands), the colloids will carry two patches that allow irreversible crosslinking of the self-assembled master-strand and one patch that serves for the recognition and reversible attachment of the single particles along the colloidal chain for the replication process. Thus, in analogy to the polymerase chain reaction (PCR) for DNA replication, single tri-valent colloids will reversibly attach to the colloidal master strand, followed by inter-particle crosslinking of the newly formed strand, which then is detached form the master by opening the bonds between the strands. The released chain copy will then serve as template for further replication processes in which the number of copies will double after each cycle.With this approach we aim to establish a technology platform for the production of sufficient quantities of simple and complex colloidal assemblies, where a well-defined or complex master-structure can only be produced and isolat