RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optimizing Antiambipolarity in OMIECs for Efficient Biohybrid Synapses' (OASYS).

assistant: **Innovation**

Neurological diseases are now the leading contributor to the global health burden, affecting one in three individuals worldwide. In response to this critical issue, the development of innovative organic mixed ionic-electronic conductors (OMIECs) that emulate the ion-regulated electronic conductivity and dynamics of biological ion channels when implemented in organic electrochemical transistors (OECTs) has paved the way for electronic devices capable of replicating neuronal functionality, namely conductance-based organic electrochemical neurons (c-OECNs). Despite the progress towards emulating biological neuron functions, current c-OECNs are limited by their inability to generate biologically plausible spike frequencies and their high power consumption, which hinder their integration with biological systems. In this sense, OASYS plans to overcome this challenge by developing innovative OMIECs with optimized ambipolarity characteristics and fabricating wearable and biorealistic c-OECNs that can be fully integrated with biological systems. This will be realized by using rationally designed bithiophene imide (BTI)-based polymers that operate at low gate voltages, enabling faster OECT devices with reduced power consumption and enhanced spike frequencies. OASYS integrates cutting-edge polymer design, advanced material characterization, and innovative device engineering in an application-oriented approach to tackle critical challenges such as antiambipolar tunability, selective sensing, wearability, and biointegration.


**Keywords:** organic mixed ionic-electronic conductors , organic electrochemical transistors, antiambipolarity, neuromorphic perception, conductance-based organic electrochemical neurons, biohybrid synapses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Increasing the information transfer of EEG-based brain-computer interfaces' (BRAINCOM).

assistant: **Concept**

Abstract: A Brain-Computer-Interface (BCI) transforms brain activity into control signal. The aim is to improve the performance. In order to improve the performance, well investigate multivariate and non-linear parameters of the EEG. In order to get under control the curse of dimensionality, a twofold approach will be used. First, parametric autoregressive (AR) models including multivariate and non-linear extensions will be applied. AR parameters are known to be a so-called maximum entropy spectral estimator, which minimizes the number of parameters. In order words, the same number of parameters allows to describe the EEG in more detail. Second, support vector machines (SVM) will be applied, since SVM's are able to handle high-dimensional feature space.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Noise pollution effects on auditory organ - pathogenesis, risk assessment, prevention and treatment' to be submitted under Sixth Framework.

assistant: **Abstract**

The mission of the proposal is to strengthen the international position of the Nofer Institute of Occupational Medicine in the field of occupational and environment-related hearing loss and shift the research and development potential towards advanced field of molecular biology and genetics.The main project objective is to transfer the knowledge to the Institute and improve the skills of Institute's researchers to develop advanced, multidisciplinary animal and human studies on individual risk assessment and treatment of noise-induced hearing loss (NIHL).The project will focus on:-exploring the data from currently being performed at the Institute clinical and epidemiological research studies on occupational hearing loss in order to predict individual risk of hearing loss;-advancing the study on the ototoxicity of organic solvents and its diagnostics; -developing advanced methods of molecular genetics to search for susceptibility genes for NIHL;-developing advanced methods of molecular genetics to explore the methods of medical prevention and gene-based therapy of NIHLThe objectives will be implemented by recruitment to the Institute experienced researchers of different specialities (epidemiolgy, biophysics, molecular biology, neurochemistry, neurophysiology and audiology) and training own staff by different experienced researchers.The project will result in development of long-lasting cooperation between the host organisation, fellow researchers and other institutions participating in the project. It will also contribute to organising the international postgraduate studies at the Institute, attracting young researchers to the field of occupational and environment-related hearing loss and hygienie, and developing their skills in the new areas.In addition, NoiseHear will h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'German presidency conference: The European research Council - an added value to the promotion of frontier research in the European research area""'.

assistant: **Innovation**

In January 2007 the Seventh Research Framework Programme (7th RFP) will start and establish the European Research Council (ERC). To celebrate the launch of the ERC and to effectively promote this key component of the Lisbon strategy, which aims to turn Europe into a globally competitive, knowledge based-society, an international conference is scheduled to take place in Berlin on 27 and 28 February 2007.With Germany assuming the Presidency of the Council of the EU then, the German government has asked the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) to design and organize this event. The main objectives of the 2-days conference are to communicate the strategy of the ERC and to discuss the major challenges the ERC is faced with in the ERA and beyond. The conference will stress the change of paradigms in European research policy since the 7th RFP has raised frontier research to a political priority and addresses excellent researchers to make Europe become the international leader in science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Building Active MicroLED displays By Additive Manufacturing' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The BAMBAM project aims at reintegrating the display manufacturing industry in Europe while enabling the era of the low energy µLED for this application. Microprinting of electrical and optical structures and active LEDs pixels (µLED on CMOS) are the solutions implemented in BAMBAM to get rid of the Thin Film Transistor (TFT) arrays controlling LCD and OLED displays; all of them being manufactured in Asia in dedicated expensive, enormous and energy-intensive plants. The new BAMBAM technology relies on the unique active µLEDs on silicon by ALEDIA, where each µLED has its own CMOS driver that can be connected to a low cost substrate by printing of micron scale bussing on any substrate.  Following micro-printing by University of Stuttgart of the XTPL's ink, containing Qustom dots color conversion components, on the µLED of Aledia, and their transfer on a low cost substrates by XDC and Xceleprint,  the contact ink is micro-printed to connect the active pixel elements to the substrates. The 2 types of display demonstrators, manufactured with this technology, are then adjusted and operated by Barco to achieve the best picture quality at the low energy consumption of the µLED for TV and video walls. The solution is compatible with a high pixel count and low pixel size on flexible substrates. Manufacturing displays in Europe, with a low energy consumption along the life cycle of the product, on low end flexible substrates and low cost, is being prepared by Aledia in its new european manufacturing-line, which is under construction with the help of partners from all over Europe.


**Keywords:** display, microLED, microPrinting, mass transfer, Quantum Dots, video walls, flexible display
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Therapeutic discovery for Inflammatory Bowel Disease' (FLAMINCO) under Horizon Europe.

assistant: **Objectives**

Inflammatory Bowel Disease (IBD)  a major cause of colorectal cancer (CRC) and a huge socioeconomic burden in Europe and beyond. IBD comprises diseases that are characterized by chronic inflammation in the gastrointestinal tract and includes ulcerative colitis (UC) and Crohns disease (CD). These diseases are lifelong, causing debilitating symptoms and can be life-threatening. IBD is caused by an interplay between the patients genetic predisposition, immune responses and environmental factors. Chronic inflammation with fibrosis is the key driver of disease complications such as stenosis, abscess formation and colon cancer. IBD affects about 3.2 million people in Europe. IBD patients have an increased risk of CRC caused mainly by chronic intestinal inflammation leading to pro-neoplastic effects. In fact, IBD patients have an alarming 2- to 5- fold increased risk of developing CRC compared to the general population. Despite many treatment options, there is no cure for IBD. The IBD health economic burden in Europe is high and estimated at over 5B /year. It is widely accepted that to overcome the challenges and to break through the therapeutic ceiling combination therapies or completely novel approaches will be needed. Due to the increasing incidence and prevalence and associated burden of IBD, the lack of effective long-term treatment options and the associated risks including CRC; IBD remains an important unmet medical need with an urgent need for novel therapies that can improve patient outcome. Here we will explore the use of a completely novel class of molecules exploiting a unique first-in-class mechanism-of-action and validate their efficacy as a therapeutic for IBD. Proof-of-concept studies will be performed in state-of-the-art mouse models. The data obtained will re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating the use of autonomously replicating plasmid vectors for cystic fibrosis gene therapy' (1994-1998).

assistant: **Concept**

The aim of the research project is to study the use of plasmids containing mammalian origins of replication for gene therapy of cystic fibrosis (CF). Previous reports from Dr. College's group have demonstrated the feasibility of using non-replicating plasmid/liposome complexes for CF gene therapy in vivo. Replicating versus non-replicating plasmids containing different reporter genes or the CFTR gene will be tested to assess whether autonomous replication improves the efficiency and duration of gene expression in vitro and in vivo. The test system will be optimised using plasmids containing viral origins of replication but since plasmids that encode viral transforming proteins are not suitable for human gene therapy trials, we will also generate plasmids that contain some of the recently identified mammalian origins of replication. Plasmid replication assays will be performed in vitro using murine and human cultured epithelial cells. Plasmids will be introduced into cells by electroporation, liposomes or calcium phosphate precipitation. Once the replicating plasmids have been tested for their relative transfection and expression efficiencies in vitro, they will be tested in vivo for correction of the C1- channel defect in CF mice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Modulating immune responses to mitigate neuroinflammation, bioenergetic decrease and cognitive decline in Alzheimer’s disease'.

assistant: **Objectives**

Background and rationale: Alzheimer's disease (AD) is the main cause of dementia, with substantial socio-economic burdens. Due to the absence of a cure, understanding disease mechanisms and developing new therapies is crucial. Age-related systemic and brain inflammation contributes to cognitive decline. Inhibiting prostaglandin 2 (PGE2) - PGE2 receptor 2 (EP2) signalling has restored youthful hippocampal functions in ageing mice, but its specific impact on AD-related deficits remains unclear. Aim: We seek to explore the effect of EP2 inhibition on bioenergetic and cognitive decline in an amyloid precursor protein knock-in (APP-KI) mouse model of AD, using neurobiology, immunology and data science. Objective 1: We will compare the effects of brain-penetrant and non-brain-penetrant EP2 antagonists on memory, synaptic function, glucose metabolism, systemic/brain inflammation and amyloid-beta (Aβ) pathology. Objective 2: We will study these effects in APP-KI mice injected with AD brain-derived pathological tau. We will then assess the impact of peripheral immune modulation on AD-like pathology spread. Objective 3: We will analyse the changes and interplay among synaptic dynamics, microglial activity, Aβ/tau pathology progression after EP2 inhibition via real-time imaging. Methodology: The study will involve various assessments, including behavioural tests, biochemical and immunohistochemical analyses, multianalyte assays, as well as multi-omics approaches that combine transcriptomics and metabolomics. Additionally, it will utilise two- and three-photon microscopy for live imaging. Expected results: We anticipate gaining valuable insights into a) PGE2-EP2 inhibition effects on AD-driven deficits, and b) whether peripheral immune re-programming restores brain functions beyond
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Joint Inference with the Universal Schema'.

assistant: **Concept**

We are getting better and better in solving various subproblems in Natural Language Processing (NLP), such as parsing, coreference or relation extraction; however, once assembled into an end-to-end system of the traditional pipeline architecture, errors cascade and magnify. The principle goal of this project is to enable new generation of NLP applications in which information flow is bidirectional, and acquired downstream knowledge increases the robustness of upstream processing. Specifically, we want to investigate bidirectional flow in scenarios where downstream processing can acquire knowledge in very rich representations, and learn from massive amounts of unlabeled data. While this goal is motivated by the need for more accurate NLP, it also relates to the fundamental problem building artificial cognitive systems that adapt to their environment, seamlessly connect complex layers of abstraction and never stop learning. The work will have direct applications, for example, in extracting meta-data from media archives, biomedical text mining and information extraction from clinical texts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Investigation and Maturation of Technologies for Hybrid Electric Propulsion' (IMOTHEP) targeting Horizon 2020.

assistant: **Abstract**

To meet the goal of a carbon neutral growth of commercial aviation, the top level objective of IMOTHEP is to achieve a key step in assessing the potential offered by hybrid electric propulsion  (HEP) and, ultimately, to build the corresponding aviation sector-wide roadmap for the maturation of the technology.The core of IMOTHEP is an integrated end-to-end investigation of hybrid-electric power trains for commercial aircraft, performed in close connexion with the propulsion system and aircraft architecture. Aircraft configurations will be selected based on their potential for fuel burn reduction and their representativeness of a variety of credible concepts, with a focus on regional and short-to-medium range missions. From the preliminary design of aircraft, target specifications will be defined for the architecture and components of the hybrid propulsion chain. Technological solutions and associated models will then be investigated with a twenty year timeframe perspective. In order to identify key technological enablers and technology gaps, the integrated performance of the electric components and power chain will be synthesized by assessing the fuel burn of the selected aircraft configurations, compared to conventional technologies extrapolated to 2035.The project will also address the infrastructures and tools required for HEP development, as well as the need for technology demonstrations or regulatory evolutions. Eventually, all these elements will feed the research and technology roadmap of HEP, which will constitute the final synthesis of the project.To achieve these ambitious goals, the 54-month project is supported by 7 R&D institutes, 11 industries (from aviation and electric systems), a service SME and 7 universities from 9 EU countries, plus 2 RTD organisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative modelling and assessment capabilities through MaaS for Manufacturing Ecosystem resiliency' to be submitted under Horizon Europe.

assistant: **Abstract**

DMaaST aims to enhance the manufacturing ecosystem's resiliency and capability of self-adaptation in response to external events. It is achieved through a Smart Manufacturing Platform comprising 4 layers: The data layer establishes a foundation for mapping manufacturing ecosystem information using ontologies and decentralized knowledge graphs, ensuring a trusted cross-organization real-time data integration. Next, a layer with a two-level cognitive digital twin is created, with the low-level DT modelling two use cases' manufacturing services production line; and the high-level DT modelling the main stages of use-cases’ sectors value chains. The resulting DTs will use human expertise-knowledge, data-driven algorithms and physical modelling to provide a reliable and robust DT of the manufacturing ecosystem. The next layer employs the data and modelling layer's information to present a multi-objective distributed decision support system algorithm combining multi-objective techniques and the latest trends in Federated Deep Learning. This makes DTs actionable models and provides the necessary information to make optimal production decisions. The fourth layer focuses on presenting the information in a user-friendly manner with timely scoreboards. Additionally, a dedicated module will assess the production's circularity and sustainability and considering products traceability through the EU-DPP. Therefore, the sustainability and remanufacturing opportunities of the production process will be improved. The project ensures scalability, providing information for replicating and trying new manufacturing processes thanks to the manufacturing services digital warehouse while assessing risks and opportunities for improvement. DMaaST innovations enable the manufacturing ecosystem to a