RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthetic glycoproteins and their interactions with receptors studied by NMR' (GLYCOSTUD), addressing dissemination and exploitation.

assistant: **Impact**

It is hard to overestimate the importance of glycoproteins as signalling molecules in Nature. Protein glycosylation is fundamental to many biologically essential processes and considering the increasing importance of glycosylation in therapeutic approaches, there is a need for novel methods for the preparation of glycoproteins in order to study their role in these cellular events, as well as to develop glycoproteins with therapeutic activities.  Most glycoprotein production methods produce mixtures of glycoforms. However, combining chemical control of post-translational modifications (PTM) like glycosylation, with readily available protein scaffolds provides a systematic platform for creating probes (homogeneous glycoproteins) of protein–PTM interactions.   To understand such interactions in biology, it is essential to study them from a structural and molecular point of view. In this project, the synthesis of naturally occurring carbohydrate-containing structures and their controlled conjugation with proteins will be carried out by means of the latest chemical and enzymatic approaches, rendering both oligosaccharides and synthetic glycoproteins amenable to be studied deeply in the context of protein-ligand binding. Well-established receptors like lectins will be selected at a first stage. A detailed picture of such interactions will be obtained through NMR experiments like STD or tr-NOESY. Additionally, the possibility to precisely incorporate synthetic carbohydrate structures containing labels, such as 13C, will greatly enhance such studies. Following these initial fundamental studies, medicinally relevant studies with e.g. selectins, siglecs, DC-SIGN and dectin will expand the project limit. The information obtained from the structural characterization of the protein-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FOSTERING WATER-AGRICULTURE RESEARCH AND INNOVATION IN MALTA' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

FOWARIM (Fostering Water-Agriculture Research and Innovation in Malta) objective is to strengthen the research capacity of the Malta College of Arts, Science & Technology (MCAST)’s Water Research and Training Centre in 4 crucial themes related to the field of water use in agriculture: (a) Decreasing Water Demand, (b) Making Use of Alternative Sources of Water (c) Renewable Desalinization, On-Farm Desalinization and Utilization of Saline Water and (d) Decreasing Negative Environmental Externalities Caused by Nutrient-Rich Farm Waters. This will be achieved by creating a favourable environment for capacity building targeting Maltese researchers, research institutions networking, research policy development. MCAST will be supported in addressing research deficiencies and networking gaps by EU partners of established scientific excellence in the targeted research topics. The proposal will develop over 3 years and is articulated into 5work packages, including one for management and coordination,  involving: capacity building through several targeted and advanced training courses, short-term staff exchanges, summer schools and virtual training; research networking and knowledge sharing through providing technical assistance to establish new demonstration sites to promote innovations and best practices in agricultural water management, (iii) helping foster new collaborations through co-design of research questions, and (iv) developing a joint strategy for high impact research and dissemination; designing a research strategy and performing dissemination and outreach activities. This will lead to strengthening  MCAST’s research and S&T capacity in water use in agriculture, enhance the dynamism between the different partners, extending the partnership of research Institutions in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combined action to study the oceans thermal skin.' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

There is in general a difference in temperature between the skin of the ocean which is observed by satellites and the sea surface temperature (SST) which has been measured conventionally from ships. Our present inability to predict how this difference varies in space and time threatens to restrict the applicability of satellite-derived global sea surface temperature datasets to studies of climate change. A number of small scientific groups around the world, including several in Europe, have developed an interest in the ocean thermal skin. In isolation such groups can make only a limited impact on questions which need to be addressed on global scales. This proposal seeks to enhance the work of individual groups within the EU by promoting collaboration in the study of the thermal skin of the oceans through a programme of concerted action. The programme aims: (a) to create a co-operative community of ocean skin temperature researchers and climate scientists using sea surface temperature, by co-ordinating European collaboration; (b) to increase European expertise in the measurement and climate applications of SST through meetings with selected international experts; and (c) to exchange practical experience and information on skin temperature measurements, techniques and problems, through workshops and exchange visits. The methods to achieve these goals will include, firstly, the creation of a communication network between the partners, using the World Wide Web. This will allow the participants to exchange scientific papers, reports, data sets, models and algorithms quickly and efficiently. The coordinating institution will have responsibility for the provision and maintenance of this facility. Secondly, two workshops will be organized in order to exchange scientific ideas,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Relay Centre for Central Italy' (RECITAL).

assistant: **Concept**

RECITAL has been active since 1995 and has achieved significant results in terms of the number of clients assisted (4157), SMEs involved in the technology transfer process (3992), company visits (495), Technology Offers (TOs) and requests (TRs) identified (357) and Transnational Technology Transfer (TTT) agreements signed (61). Moreover, RECITAL has developed and implemented new tools for the identification of qualified TRs and TOs and the classification of SMEs according to their level of innovation, as well as a best practice quality assurance (QA) procedure aimed at evaluating the real commitment of clients and the code of conduct of the IRC. In the consortium proposed, which maintains Consorzio Pisa Ricerche as co-ordinator and Etruria Innovazione, and Parco Tecnologico dell'Umbria-Sitech, as partners, Sviluppo Italia (which now focuses on Southern Italy only) will be replaced by Firenze Tecnologia, (sub-contractor of Consorzio Pisa Ricerche under the present mandate). The same geographical area ( Tuscany and Umbria) will be covered and the common strategy and communication tools which give the IRC characteristics of both a unique and an independent organization maintained. Thanks to the tools developed in the within the IRC network, the close con tacts established with other IRCs and the QA procedures activated, in the next 4 years phase of activity RECITAL aims to obtain even more concrete results than those achieved in the past. The target for signed TTT agreements in the present mandate 2000-200 4 is 20, the proposed TTT agreements were 25 (25% increase with respect to the present mandate), after evaluator recommendations our target for signed TTT agreements is 33 (33% increase with respect to the proposal submitted). This target is very ambitio us if we conside
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'REsearch network for forward looking activities and assessment of research and innovation prospects in the fields of Climate, Resource Efficiency and raw mATErials' in the context of a Seventh Framework call.

assistant: **Objectives**

RECREATE is a policy support network that will collect strategic and analyse information about medium and long term research and innovation trends and prospects.The aim of RECREATE is to overcome this fragmentation, and to create a clear cut research agenda for the Horizon 2020 priority of climate change, raw materials and resource efficiency using an RTD perspective for a transition management strategy that (a) looks at the trade-offs and synergies between raw materials, resource efficiency and climate change mitigation, (b) engages key stakeholders in a pro-active manner, and (c) has a perspective beyond the year 2020.RECREATE seeks to•Engage a wide range of stakeholders (industry, academia, research, etc) to create an effective, dynamic and sustainable network.•Provide policy makers with a detailed mapping of the most relevant actors and initiatives in the fields of Climate Change, Resources Efficiency and Raw Materials across Europe and overseas.•Provide the policy makers with detailed information regarding medium and long term research and innovation trends and prospects, and carry out forward looking analysis in the areas of Climate Change, Resources Efficiency and Raw Materials.•Propose, deploy and monitor indicators for assessing the impact (in terms of policy, economy, society, sustainability) of EU R&I cooperation both within the EU and overseas.•Produce regular quantitative and qualitative briefings with information, trends and strategic options for R&I addressed to EU research managers and policy makers.RECREATE is a balanced partnership that combines key players in the areas of raw materials, resource efficiency and climate actions, at scientific and industry levels, with strong methodological knowledge partners, ensuring that the network• has in depth know
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Tidal inlets dynamics and environment' (TIDE) under Fifth Framework.

assistant: **Objectives**

Tidal areas, such as lagoons and estuaries, are complex and delicate environments subject to rapid morphological and ecological change, often in response to strong human interference. The problems connected to tidal areas have been recognised by the International Ramsar Convention on Wetlands: 445 of the 844 protected wetlands of international importance listed by the Convention are located in Europe. The TIDE project aims at developing comprehensive models of tidal environments incorporating both physical and ecological processes. Useful models of tidal systems cannot separately describe their biology and physics without failing to predict the overall system behaviour. Progress in tidal research requires a new generation of models with far reaching economic and environmental benefits. This is the goal of the TIDE project. The socio-economic consequences of system change are considered as an integral part of the programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Calibration free optical monitoring systems for continuous on-line blood monitoring' in the context of a Fourth Framework call.

assistant: **Objectives**

Near patient testing has brought with it major benefits, particularly with regard to the reliability and efficiency with which the management of the critically ill patient is now achieved. The continuous feedback possible with some recent systems, Furthermore, allows ongoing titration of therapies with undoubted added benefits for final outcome, particularly in clinical states where aggressive treatment is required and where even marginal changes in therapeutic manoeuvres have a major impact on outcome. The core parameters that are the most import ant to monitor on a continuous basis are pH, PO2, pCO2, glucose and K+ (conclusion of EU Concerted Action ERB BMHI CT92 0015). However, to date, no viable, lo w cost or operationally simple monitor is available and widespread benefit for the EU healthcare system unlikely from existing cumbersome commercial samples. The basic analytical chemistry of the proposed parameters is well established, and it is the intention of the proposers to now integrate this into robust clinically feasible prototype monitoring equipment suitable for cardiopulmonary by pass, dialysis and general intensive care. Most importantly, it is intended to achieve a versatile calibration free monitor that for the first time removes the need for complicated drift/accuracy checks on the part of the clinical operator, and which can ultimately serve as a platform for further products in different (non health care) sectors. The technical objective will be a monitor with single sensors and sensor arrays that slot (in series) into existing extra corporeal blood sampling lines (venous and arterial). The sensors would exploit full optical spectral data emanating from analyse sensitive fluorescent/reflective membranes structured to give high blood compatibility. Uniqu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Understanding mechanisms behind reliable future extreme precipitation estimation over Europe' to be submitted under Horizon 2020.

assistant: **Abstract**

Extreme precipitation events are among the most damaging climate extremes worldwide. Globally, precipitation extremes are expected to intensify as the climate warms, however, Europe stands out as a region with weak confidence in future extreme precipitation changes. Our lack of knowledge is explained by the variety of mechanisms at play, from local to hemispheric scales, and by two persisting limitations: the deep convection not explicitly resolved in climate models and large uncertainties in future regional atmospheric circulation changes. UMBRELLE aims to characterise the evolution of precipitation extremes over the 21st century in Europe and to provide more reliable projected changes by better understanding the physical mechanisms at play. Innovative modelling experiments are proposed to explore how observed extreme precipitation case studies could respond to climate change and what mechanisms control the future changes. To that end, novel data, tools and methods will be exploited through the use of high-spatial convection-permitting regional climate modelling for the realistic simulation of extreme precipitation that will be combined with the emergent ‘storylines’ approach to identify plausible future pathways for regional atmospheric circulation from a large ensemble of state-of-the-art Earth System Models.The original framework offered by UMBRELLE will allow a leap in our understanding of the regional impacts of climate change on extreme precipitation. It directly addresses each of the two current limitations in our knowledge and provides an innovative way to bridge the gap between the fine scale explicit simulation of precipitation and the most comprehensive simulation of the climate system in order to benefit from their respective strengths and latest advances.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deciphering the molecular mechanisms of HIV DNA nuclear import and the impact of 3D genome organization on integration site selection' (RetroChrom).

assistant: **Innovation**

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA functions, primarily transcription. During retroviral infection, histone-free viral DNA copy is synthesized from viral genomic RNA. vDNA will ultimately integrate into the host genome to ensure its maintenance and expression.  Understanding retrovirus-host interactions at the genomic level, and the peculiar mechanisms by which lentiviruses, including HIV-1, and their related gene transfer vectors, are imported into the nucleus, loaded with nucleosomes, integrate in, and interact with, the human genome will provide valuable information about lentiviral replication and establish the basis for the development of safer and more efficacious lentiviral vectors for human gene therapy. Our objectives are: 1-To identify and characterize cellular proteins associated with the HIV-1 PIC, and determine their roles in nuclear import and/or integration. 2-To explore the role of the epigenome of unintegrated vDNA in HIV-1 gene expression from unintegrated and integrated vDNA. 3- To determine the impact of nuclear organization on integration site selection and on viral and host transcription. State of the art technologies will be applied to achieve these challenging objectives. If successful, this project will make an outstanding contributions not only to the field of HIV biology but also for the development of safe lentiviral vectors for gene therapy.


**Keywords:** HIV, nuclear import, epigenome, 3D genome structure, integration sites selection, gene therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Higher-dimensional topological solids realized with multiterminal superconducting junctions'.

assistant: **Innovation**

Recently I revealed a deep operational analogy between an exotic material and an electronic device, i.e. between a 3-dimensional topological solid and a 4-terminal superconducting junction. Specifically, the 3d Weyl singularities revealed in the energy spectrum of this quantum device give rise to quantized trans-conductance in two leads that is typical for 2-dimensional topological Quantum Hall materials. The quantized value can be  tuned with the third control phase. I propose to capitalize on this breakthrough by realizing artificial n-dimensional (topological) solid materials by (n+1)-terminal superconducting junctions. This seemed to be fundamentally forbidden so far. In particular, in the framework of one research direction I will address the realization of higher Chern numbers. The edges and interfaces are important in topological solids, they need to be structured. For the artificial topological materials made with multi-terminal superconducting junctions such structuring is impossible in geometric coordinate space. However, the fact that the charge and superconducting phase are quantum-conjugated quantities provide the unique possibility for  the structuring in multi-dimensional charge space that I will access in the framework of another direction.  These two research directions will be supplemented by a more technical effort devoted to computational (quantum) dynamics of multi-terminal superconducting junctions.The proposed way to ""conquer"" higher dimensions for condensed matter physics is of clear fundamental importance. Exciting applications are at the horizon, too. The exotic quantum states under consideration can be topologically protected and thus useful for quantum information processing. Quantized trans-resistance as well as other topological invariant