RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'BREATH: Biomarkers for Respiratory diseases detected in Exhaled Air through a new Technological instrument for research and Healthcare markets.'.

assistant: **Objectives**

Each year in Europe, lung diseases are responsible of more than one million deaths and extensive costs estimated at €380 billion. These respiratory diseases, such as chronic obstructive pulmonary disease, lung cancer, asthma and tuberculosis, are very difficult to detect and usually diagnosed in late-stages once there is a significant burden of disease within them. BREATH project consists to develop, manufacture and market a research instrument to study and to diagnose respiratory diseases. The concept is based on a completely new method to collect and analyse particles via exhaled air in the small airways to easily identify chemical changes and potential biomarkers for respiratory diseases. The PExA method has the potential to fundamentally change the way lung diseases are diagnosed and treated today by offering a best alternative of the existing methods on market, which brings a substantial commercial potential. By doing a simple breathing test and without any potential risk for the patients, PExA's instrument provides a quantitative, reliable, user friendly, non-invasive, less painful, faster, repeatable method for early-stage diagnosis. PExA's clients are all those who are currently actively looking for biomarkers to figure out the patient's health conditions such as lung researchers and healthcare professionals within health services, academia and pharmaceutical companies initially in the EU and then the US. The objectives of BREATH project Phase1 are to: (1) prove through a feasibility study the potential to develop a real-time and stand-alone analysis/diagnostic device; (2) enhance the competitiveness and profitability of the service by improving the quality and reliability of the system via (i) the checking system, (ii) designing and developing our own disposabl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeting tumour-host interactions in paediatric malignant gliomas to reinvigorate immunity and improve radio- and immunotherapy efficacy' (HIT-GLIO).

assistant: **Innovation**

Paediatric high-grade gliomas (pHGGs) are malignant, deadly tumours developing in infants and children. Mutations in histone coding genes disturb epigenetic regulation and in cooperation with other oncogenes promote tumour initiation and progression. pHGGs are fast-growing and diffusive which makes them hard to remove or treat. Surgery (unattainable in midline brain regions) and radiotherapy (RT) remain the only option with transient benefits as median survival is 9-15 months. Those tumours are immunosuppressed, thus immunotherapy is ineffective. We propose that knowledge of tumour-host interactions in the tumour microenvironment (TME) would reveal novel targets allowing to find new ways to eradicate mutated tumour cells, improve efficacy of RT, and reinvigorate anti-tumour immunity. To achieve these ambitious goals we built up the international, multidisciplinary consortium HIT-GLIO. We will i) use latest single-cell technologies and multimodal imaging to characterise tumour-immune cell interactions in a large spectrum of pHGG patient samples; ii) create cellular and animal models of increasing complexity: human glioma-microglia co-cultures, DIPG-derived organoids complemented with iPSC-derived immune cells and syngeneic pHGG mouse models which would be platforms for mechanistic studies and drug screening; iii) evaluate hypoxia-inducible epigenetic inhibitors and blockers of tumour-host interactions to improve RT and immunotherapy responses; iv) generate nanocarriers functionalised to target immune cells and deliver drugs to the brain; v) develop more effective CAR-T cells that together with TME reprogramming and RT would boost anti-tumour immunity; vi) assess neurodevelopmental alterations and psychological consequences of disease and foster psychological approaches t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Characterising the spatial organisation and regulation of the Wnt receptor complex in stem cells and cancer' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Wnts are a family of secreted glycoproteins that control maintenance and proliferation of stem cell reservoirs during tissue homeostasis and regeneration after injury. Deregulated Wnt signalling due to mutations in important signalling intermediates is strongly linked to disease. The complex molecular mechanisms mediating Wnt-induced cell responses are therefore of wide interest and the underlying protein interactions provide attractive drug targets, particularly in regenerative medicine and cancer treatment. The earliest events that occur after Wnts bind their receptors at the cell surface, such as receptor endocytosis and recruitment of cytoplasmic effectors, are decisive for downstream gene activation but the underlying mechanisms by which these events process and tune the Wnt signal remain poorly understood. The key objective of this proposal is to resolve critical molecular events that drive initiation of the Wnt cascade in stem and cancer cells. By using a novel tool developed in the Maurice laboratory to detect endogenous Wnt-bound complexes, The Applicant will focus on the following central objectives: 1. To elucidate Wnt receptor localisation in sub-cellular compartments2. To examine the regulation of Wnt receptor trafficking and turnover in response to Wnt signalling3. To investigate how cancer cells exploit Wnt receptor trafficking to drive tumour growthTo meet these objectives, The Applicant will be trained to employ an integrated approach combining biochemistry and genome editing in intestinal organoid cultures with advanced imaging including immuno-electron microscopy to develop a unique set of tools to study Wnt receptor trafficking and turnover at the endogenous level. The expected insights will be vital to understand how pathway activation is controlled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Energy efficiency Building Enhancement through performance guarantee Tools'.

assistant: **Concept**

EBENTO is aiming to develop an integrated platform for all actors involved in building and renovation sector to provide one-stop-shop to better coordinate and manage Energy Performance Contracting, bringing together the needs from all actors involved in enhancing the building stock.Through EBENTO, citizens will increase their implication in building energy efficiency enhancement, and both public institutions and energy communities will be able to identify potential energy efficiency improvements in residential housing stock, with SMEs and ESCOs support. Furthermore, with EBENTO platform, new business models for optimizing the financial (and, indirectly, other) resources available will be validated:•EBENTO will explore the best financing and collaboration schemes to set up energy services.•EBENTO will study how to enhance current Energy Performance Contracting (EPC) for Demand Side Mechanism (DSM) services and what kind of investment options (grants, loans…) can be implemented to increase the number and impact of energy efficiency projects in the city/region•By using digital tools, EBENTO will gather data from EPCs, financial schemes and energy savings to give to the citizens the required trust for investing in new solutions, and to companies the relevant information to reduce costs and easily replicate the work developed.EBENTO will ensure the exchange of relevant information between the different actors, making the renovation process cost-efficient and easy to operate and replicate. The platform will collect data related to performance contracts and guarantees, devices monitoring, energy savings, building information modelling, users’ opinions and comfort levels, among others.


**Keywords:** Renovation, energy efficiency, one-stop-shop, Energy Performance Contracting,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Highly Ethanol-Selective Electrocatalytic CO2 Reduction Enabled by Site-Specific Heteroatoms Doped Single Atom Catalysts Supported Cu Clusters' (SAC-Cu-CO2RR).

assistant: **Innovation**

Electrochemical CO2 reduction reaction (CO2 RR) driven by renewable power is a promising way to convert CO2 to fuels and chemicals, which has been proposed as a sustainable process for the artificial carbon cycle. Among all products, ethanol (C2H5OH) has received extensive attention because it can be directly used as fuel in internal combustion engines and industrial power generation. Cu-based catalysts can efficiently promote C-C coupling toward C2+ products in CO2 RR. However, most Cu-based catalysts still show an insufficient selectivity for C2H5OH (<50 %) due to unfavorable adsorption of several oxygen-containing key intermediates, which cannot achieve its commercial value. As a frontier in materials science, single-atom motifs anchored on N-doped C support (carbon-based SACs), are widely investigated due to their maximum atom-utilization efficiency and highly metal dispersion. Especially, in the field of eCO2 RR, compared to the pure N-C, SACs exhibit an excellent CO selectivity because of the easily optimized coordination environment along with a reconstructed structure. Therefore, combining SACs with Cu-based catalysts in the proper configuration can increase the local CO concentration near Cu-based materials at a low overpotential where Cu alone would be incapable of doing the CO2-to-CO conversion. Meanwhile, the moderate electron-donating ability of SACs will further stabilize the oxygenic C2 intermediate to make the hydrogenation pathway toward C2H5OH production more favorable. As a result, the objective of this project is to design a carbon-based SACs supported Cu clusters architecture by a chemical in-situ growth process to let it serve as a high-efficient catalyst for achieving a high C2H5OH selectivity (> 75 %) at a low overpotential (< 800 mV). This proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Enhancing the innovation management capacities of SMEs in East Poland' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main objective of the project is to facilitate the access to European and international markets by providing growthoriented, integrated business and innovation support services that will help to strengthen the competitiveness and sustainability of the enterprises in the EU countries. The proposal also focuses on strengthening the collaboration between different key actors in the innovation chain. Main objective of the project will be implemented by specific objectives: 1. Economic potential increase among enterprises benefiting from SME Instrument in the framework of Horizon 2020 by ensuring that the SME Instrument beneficiaries will receive the most appropriate services to enhance the probability of successful exploitation of the innovation project supported by the Instrument and to leave a footprint for the future sustainable growth of the beneficiary by identifying bottlenecks and indicated solutions with the help of a capable coach. This objective will be implemented by the tailor made service of The Key Account Management (KAM) in the framework of WP1. 2. Increase of innovation potential of small and medium sized enterprises by providing hider quality innovation support services. This objective will be implemented by specially designed activity: Enhancing the innovation management capacity of SMEs (EIMC) in the framework of WP2 of this project and will be addressed to SMEs with a real potential for international growth via product, process, service or business model innovation but lack the knowledge, skills or ability to manage innovation activities. The main goal of the service is to make the innovation system, in the company, more efficient and effective. Specific objectives will be implemented by five Partners of Enterprise Europe Network East Poland Consort
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Harnessing Non-Classical Carbocations for Stereoselective Synthesis' under Horizon Europe.

assistant: **Concept**

Stereoselective synthesis is a central aspect of modern organic chemistry, enabling the precise formation of specific stereoisomers in complex molecular architectures. Key to this process are reactive intermediates such as carbenes, radicals, and carbocations. However, achieving complete stereocontrol over non-classical carbocations in the stereoselective synthesis of acyclic molecules remains a formidable challenge.These fascinating carbocations, despite decades of research, exhibit unpredictable reactivity, making the controlled creation of stereocenters particularly difficult. In this proposal, our primary goal is to achieve comprehensive stereocontrol over non-classical carbocations. We plan to accomplish this by first identifying the specific substitution pattern necessary to generate these carbocations as a single isomer. Then, we will focus on precisely controlling their reactivity to form stereodefined adjacent C–X and C–C bonds at distant positions from the initial carbocation, through molecular rearrangement. This approach not only aims to tame the unpredictable nature of non-classical carbocations but also to harness their reactivities to create highly complex and defined acyclic molecular structures. Additionally, we aim to pioneer new strategies for synthesizing polysubstituted cyclobutanes, and strained fused ring system utilizing bismetalated species, an accomplishment that has never been achieved, despite the growing use of these structures as potential bioisosteres. These methods represent a significant advancement in the stereocontrolled synthesis of complex molecules, addressing longstanding challenges in regioselectivity, substitution patterns, and stereochemistry. By harnessing the unique reactivity of strained rings and non-classical carbocations,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Epicuticular electrification: spontaneous charging of materials at the world's largest bio-air interface', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The materials on the outer plant surface create the world's largest bio-air interface. Invisibly, this surface spontaneously charges when hit by raindrops and solid materials. This is due to contact electrification, a phenomenon used in technologies like printing and energy harvesting. Yet, extraordinarily little is known about its role in nature and how biosurfaces charge.   EpiC will target two exciting and unresolved questions: a) can one exploit the generated charges to power high-tech devices at the leaf-air interface? and b) how is the organism affected by the electric fields generated on the outer leaf surface? The core of EpiC is thus a detailed surface analysis to gain the highest resolved insights in solid and liquid contact electrification of biosurfaces. To achieve this, I will combine studies of materials surface charging, chemical, and topographical analyses with observations of cellular responses, plant growth, and adaptation.This data set will then indicate how to engineer material systems named 'artificial leaves' that can be installed on the plant leaf or sprayed on it to harvest the contact charges for technical purposes. EpiC will eventually enable energy harvesting, environmental and plant health sensing, communication with robots, and electrocatalytic reactions - autonomously driven by electricity and reactants from the leaf environment. Moreover, I will develop additional features in the materials of the artificial leaf to specifically protect the plant and to boost its growth during energy harvesting.The result of EpiC will be new insights into contact charging of materials in nature, its effect on plant life, and a ground-breaking, energy-autonomous, and sustainable technology platform for the world's most significant bio-air interface with cros
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'European Master of Science Course in Radiation Biology'.

assistant: **Concept**

The European Master of Science course in Radiation Biology has been developed over a period of 5 years. It is characterized by a joint and integrated action of five universities from five Member States. Its overall aim is to maintain and expand the expertise and competence within the European Union and other European countries in the radiobiological basis of radiation protection, to disseminate the latest results of national and Community research programmes to those who enter into the field and to produce experts with sufficient breadth of knowledge in all areas of classical and molecular radiation biology. Since no single institution in Europe could run such a course a cooperative action of several universities from different EU Member States has been developed for this purpose.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of the first Water-based industrial chiller cooled by ambient air'.

assistant: **Objectives**

Most industrial production processes require cooling to ensure appropriate temperature for effective operations. Data centers, manufacturing facilities, petrochemical plants, etc. all depend on the degree to which cooling systems provide optimal operating temperatures to tools, workpieces and machinery. These refrigerants often contain fluorinated gases (which pose a threat to the environment), while most natural refrigerants result in usage constraints (compliance with dangerous substances and explosive atmospheres regulations; flammable properties, very high-pressure conditions).  Leviathan Dynamics is an innovative startup founded in 2016. LD aims at developing a Water-based industrial chiller cooled by ambient air offering various advantages: abundant and inexpensive base material, no operational risks and 30% higher energy efficiency when compared to current solutions. We have already developed a relevant prototype which has been tested in our laboratory, allowing us to reach TRL 6.  Our technology aims at developing vapor-compression mechanical refrigeration systems (chillers) involving closed recirculating systems using a single fluid to produce cold and to transfer cold to the process. We are currently developing the four components of our chillers: heat exchanger blending the circulating loop and the refrigeration loop, high speed compressors, multi-channels condensers and adjustable expansion valves.  Starting with two market segments (Laser machine cooling and Electrical cabinets cooling), our ambition is to remove fluorinated gases from the cooling industry. We have already validated our supply chain and we have negotiated distribution agreements (sales under white label, tied sales) with value added resellers. We are applying SME Phase 1 to validate the tec