RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Translational and Transdisciplinary research in Modeling Infectious Diseases'.

assistant: **Concept**

TransMID focuses on the development of novel methods to estimate key epidemiological parameters from both serological and social contact data, with the aim to significantly expand the range of public health questions that can be adequately addressed using such data. Using new statistical and mathematical theory and newly collected as well as readily available serological and social contact data (mainly from Europe), fundamental mathematical and epidemiological challenges as outlined in the following work packages will be addressed: (a) frequency and density dependent mass action relating potential effective contacts to transmission dynamics in (sub)populations of different sizes with an empirical assessment using readily available contact data, (b) behavioural and temporal variations in contact patterns and their impact on the dynamics of infectious diseases, (c) close contact household networks and the assumption of homogeneous mixing within households, (d) estimating parameters from multivariate and serial cross-sectional serological data taking temporal effects and heterogeneity in acquisition into account in combination with the use of social contact data, and (e) finally the design of sero- and social contact surveys with specific focus on serial cross-sectional surveys. TransMID is transdisciplinary in nature with applications on diseases of major public health interest, such as pertussis, cytomegalovirus and measles. Translational methodology is placed at the heart of TransMID resulting in the development of a unifying methodology for other diseases and settings. The development of a toolbox and accompanying software allow easy and effective application of these fundamentally improved techniques on many infectious diseases and in different geographic contexts, wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Elimination of Senescent Cells Approach for treatment of COPD'.

assistant: **Innovation**

Chronic Obstructive Pulmonary Disease (COPD) is estimated to affect up to 600 million people worldwide and by 2020 it will become the third most frequent cause of death. In Europe alone, COPD affects up to 10% of people (i.e. more people than breast cancer and diabetes) and it takes the life of around 300,000 Europeans each year. Current therapies are associated with a variety of side effects some of which can be acute and even life threatening. Moreover, none of the existing medications for COPD has been shown conclusively to modify the long-term decline in lung function thus, COPD remains a disease with a significant unmet medical need.Our approach is focusing on the pharmacological elimination of senescent cells (i.e. cells that have stopped dividing, but do affect their microenvironment) which accumulate in tissues with age and contribute to multiple age-related diseases, including COPD. In particular, we recently discovered that with the use of a particular molecule, we could efficiently target the molecular mechanisms that are responsible for the viability of senescent cells, leading to specific elimination of these cells from tissues. In turn, the goal of the PoC project is two-fold. (1) The first goal is to establish the technical feasibility of our idea by testing the effect of the identified molecule on the disease development and progression using the COPD mouse model we developed. (2) The second goal is to establish the business feasibility of our revolutionary approach by taking the necessary steps towards its commercialization, focusing on the creation of strategic alliances with key private sector companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Homeostatic regulation of mesenchymal stem cells in the haematopoietic stem-cell niche', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The cells forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear. Our recent studies have demonstrated that mesenchymal stem cells (MSC) identified using expression of the intermediate filament protein nestin constitute an essential HSC niche component. Nestin+ cells contribute to bone formation, contain all the mesenchymal activity and can self-renew and expand in serial transplantations. Nestin+ MSC are spatially associated with HSC and fibres from the sympathetic nervous system, and highly express HSC maintenance genes. These genes and others triggering nestin+ MSC differentiation are selectively downregulated during enforced HSC mobilisation or β3-adrenoceptor activation. Parathormone treatment doubles bone marrow nestin+ cells and favours their osteoblastic differentiation. In contrast, in vivo nestin+ MSC depletion rapidly mobilises HSC from the bone marrow to extramedullary sites. Purified HSC rapidly home near nestin+ MSC in the bone marrow of lethally irradiated mice, whereas in vivo nestin+ MSC depletion significantly reduces bone marrow homing of haematopoietic progenitors. These results uncover an unprecedented partnership between two distinct somatic stem cell types and argue for a unique niche in the bone marrow. Nestin+ MSC sharing some properties with the ones previously characterised in post-natal bone marrow are present in the foetal liver. In this proposal, we will characterise specific functions nestin+ cells in the adult HSC niche, and will analyse the role of nestin+ MSC during developmental HSC migration. We will also study the homeostatic regulation of the bone marrow stem-cell niche by analysing the role of autonomic and hormonal signals on the proliferation and fate of MSC and HSC. These studies will offer insight into
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Formation and Visualisation of the Social and Political Order of Princes in late Medieval Europe. A Comparative Study between the Empire and England' in the context of a Seventh Framework call.

assistant: **Objectives**

This project examines the formation and differentiation of princely elites in pre-modern European rank societies. The project concentrates on the late Middle Ages (1200–1500), a key period in these processes, with geographic focus on the Empire and England. In both polities new princely elites emerged during this period. Yet, they did so in the context of the establishment of two different monarchical principles, the elective kingship in the Empire and the hereditary kingship in England. In the Empire, the electoral princes became a distinctive group and constituted themselves as the pillars of the imperium. In England, the title of duke appears to have been introduced to distinguish members of the royal family from other magnates. In examining these complex social and political processes in both polities the project contributes to establish a typology of different ways of constructing societies in pre-modern Europe using an interdisciplinary, comparative approach. The project combines history, architectural and art history, archaeology and semiotics to analyse princely actions, princely architecture and heraldry. In so doing we will endeavour to determine the strategies developed and deployed by princes in late medieval Europe to represent and improve their rank and thus their significance. The comparison sheds light on several key issues such as whether the emperorship, unique in Europe, enabled the development of a king-like position for (electoral) princes, and how in different political contexts the position of the magnates in relation to each other and the king was communicated and perpetuated. This project breaks new ground on several frontiers. Interconnecting different disciplines, it crosses existing subject boundaries and thus opens up new ways of fruitful co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Phospholipid and glycolipid recognition, interactions and structures by magnetic resonance', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

In this specific targeted research project we intend to use cutting-edge nuclear magnetic resonance (NMR) techniques to develop a sensitive, rapid and integrated approach to understanding the mechanisms of lipid binding proteins. The project will generalize and accelerate the efforts to characterise a range of peripheral membrane proteins, thus providing new insight into an important class of proteins which play a key role in regulating complex cellular pathways.Model membranes will be designed to mimic various types of cellular membranes for selected protein modules which will be prepared by specific advanced tailored protein expression methods. The generation of focussed lipid molecule libraries will allow definition of membrane targeting specificity, and the synthesis of novel spin labels and micelle-forming compounds will facilitate the measurement of the angles and depths of bilayer insertion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enhanced selectivity VOC detection using novel GC-QEPAS' (EVOQUE), addressing dissemination and exploitation.

assistant: **Impact**

Volatile organic compounds (VOCs) are organic chemicals that have a high vapor pressure at room temperature. Based on their origin and formation mechanisms, VOCs can be markers in many industrial processes; in food production as quality markers, technological indicators, process contaminants; in plant phenotyping as botanical/geographical tracers, authenticity markers; and in crops storage as shelf-life indicators. VOCs also pose a range of hazards to human health and the environment. EVOQUE’s main objective is to develop a novel photonic-based sensory system with potential to outperform the current standards and to meet the challenging requirements of at-line, on-line & in-field needs of Agriculture, Food, Environmental Pollution monitoring and Industrial Emissions monitoring. EVOQUE will combine gas chromatography (GC), Quartz Enhanced Photo-Acoustic Spectroscopy (QEPAS), long wavelength quantum cascade lasers (QCLs) and mid-IR metasurfaces to produce a compact, easy to use, low cost, at-line and ultimately online, field deployable VOCs analyser that will have equivalent performance to the gold standard lab based GC-MS. EVOQUE will leverage GC’s separation of components from complex mixtures, and QEPAS’s high sensitivity, specificity and quantification. Unlike simpler GC detectors, QEPAS will provide molecular recognition based on the specific spectral features of single VOCs. The system measures the target compound even in presence of interferents, thus avoiding issues with poor repeatability of elution times and reducing the false positive rate relative to GC with non-specific detectors. Also, optical spectroscopy of many VOCs is hampered by absorption by atmospheric compounds at the wavelengths of interest or overlapping absorption features of related molecules; us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Strong, sustainable and waterproof cardboard pallet that equals load carrying capacity of wooden pallets'.

assistant: **Objectives**

According to the United Nations Economic Commission for Europe (UNECE), there are 4 billion wooden pallets in circulation in Europe right now, this means 108 billion kg of dead weight. To transport this weight 100 km, trucks will require 334M litres of fuel that will emit 880M kg of CO2.MANDRILADORA ALPESA S.L., a company founded in 1991 that manufactures and commercialises mandrels, tubes and rings spiral cardboard, has developed Upalet.Upalet will be the first commercial cost-effective and recyclable cardboard pallet that is as strong and has the same load capacity as wooden EUR pallets (1500 kg), yet it is 19 mm lower (13%) and 21.5 kg lighter (80%).Currently, there are several models of cardboard pallets on the market, but none of them offers all the benefits as Upalet has: strength and durability; massive CO2 reductions and fewer trucks on the road (traffic congestion, wear and tear to highways...); 100% recycled (corrugated cardboard and cardboard tubes attached only with green adhesives); suitable for heavy loads (1,500 kg);; waterproof and resistant to wet conditions; do not need special forklift attachment; no need for any thermal or phytosanitary treatment; 25% cheaper that EUR pallets.The project provides significant returns. By 2023 there will be 20 people employed directly in manufacturing and selling UPALET, with many more employed indirectly, both within the company, their suppliers and the companies that license the technology. Considering total project costs of 2M, by 2023, the project earns a return on investment of over 1000%, an internal rate of return of 66% and a net present value of over 15M€.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Services enhancing the innovation management capacity of SMEs in the Enterprise Europe Network 2019' to be submitted under Horizon 2020.

assistant: **Abstract**

Successful growth companies tend to be significantly better at innovation management than average. However, most SMEs and SME support organisations consider the inability to manage innovation processes efficiently and effectively as one of the most important barriers to create European economic impact (competitiveness, growth and jobs) from innovation activities in SMEs.   The objective of this project proposal is to address these problems by providing services enhancing the innovation management capacity of SMEs wishing to develop innovation projects with a strong European or international potential. There are two SME target groups that will receive 74 7-day work packages.1. 37 SME beneficiaries of the funding schemes SME Instrument, Fast Track to Innovation (FTI) and Future and Emerging Technologies Open ( FET-Open) under H2020  will be supported by Key Account Managers (KAM); and 2. 37 SMEs with significant innovation activities and a high potential for internationalisation will be supported by EIMC experts to ensure that the innovation management capacity of the SME is increased The specific objectives related to the first target group are to ensure that SME beneficiaries of H2020 can exploit their full innovation potential. A KAM will identify weaknesses in the innovation capacities of the SME, identify suitable coaches who will address the identified weaknesses and facilitate the SME- coach interaction. The specific objectives related to the second target group are to ensure that the innovation management capacities of the SMEs increase. An EIMC export will carry out innovation management capacity assessments, set up an action plans to address identified bottlenecks and implement the action plans.  Five partners: IVF, Acreo, RISE, LTU Business AB and Invest in Ska
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Enhancing Tensor Network Approaches for Rydberg Atom Quantum Simulators' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Recent experiments with ultracold atoms, trapped ions, Rydberg atoms, and superconducting circuits succeeded in realizing quantum many-body states at unprecedented sizes and thus investigating their static and dynamical properties. These achievements have boosted the search for protocols to observe exotic phases of matter in quantum simulators and to implement quantum computations unaffordable for classical supercomputers. I aim to investigate Rydberg-atom platforms, improving their efficiency for future quantum simulation and computation tasks, motivated by their versatility and manipulation capability. Classical numerical simulations are fundamental to developing quantum simulators, engineering efficient experimental protocols, and benchmarking the results. Still, an exact representation for large quantum many-body states is highly inefficient and impossible to achieve for the sizes available in current experiments. I will exploit advanced numerical tensor network methods to simulate the out-of-equilibrium properties of highly constrained quantum phases, as topological spin glasses and quantum scars, recently realized on Rydberg-atom high-dimensional lattices. Indeed, tensor networks are a balanced approximation between accuracy and computational resources and are the ideal set of tools to investigate constrained regimes in quantum many-body systems. Realizing this project first at the Lukin Quantum Optics Group at Harvard University and then at theQuantum Theory Group at Padova University, I will access world-leading experimental and numerical expertise to perform cutting-edge analytical, numerical, and experimental investigations on Rydberg atom platforms. In addition, I will acquire experiment modeling expertise and apply them at the near-future quantum computation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GRAIL-2: GNSS-based ATP System for Railway Low Density Lines' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The objective of GRAIL-2 is to develop and validate a GNSS based ETCS prototype/application in Rail Low Density Lines. Starting from the work of GRAIL, GRAIL-2 goes further in the implementation and testing of one of its applications so that a real validation of the application against user needs can be performed, thus achieving a system/application closer to a final product.The proposed application is Absolute Positioning, combined with Train Integrity, in a context of Low Density Lines.Absolute Positioning is considered to be a very promising application as it can achieve a full on-board localisation of the train, thus reducing or eliminating the trackside equipment for localisation (balises). Besides, combined with the Train Integrity application, we can achieve the “positive train detection” that allows a future implementation of “moving block” systems (future ETCS level 3). That is also compatible with other initiatives like Low Cost ETCS or Regional ETCS. Freight transport will also benefit by knowing the completeness of the train.The framework of low density lines is considered to be more adequate for a short-term implementation of the GNSS applications:- The operational requirements of the application are less demanding.- There is no need for interoperability in short term, therefore, we can propose an application without the need of a formal adoption of the changes needed in the ETCS specification, but allowing for a future interoperable implementation when the ETCS specifications will be upgraded.- Costs are kept low: The current ATP/ETCS means great investments in the LDL but this is not feasible because of the limited budget dedicated to the LDL in the railway community.The ETCS environment is also preferred because ETCS is a standard system whose features a