RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Kleptoplasty: The sea slug that got away with stolen chloroplasts' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Rationale: Photosynthesis is almost exclusively restricted to algae and plants, with the exception of some protozoans, flatworms and marine slugs that acquire chloroplasts from algae. In metazoans, the capacity to incorporate functional chloroplasts (kleptoplasty) for long periods of time has only been described in sacoglossan sea slugs. Some species retain kleptoplasts photosynthetically active for several months that persist without access to algal gene products and despite the release of potentially dangerous metabolites, including reactive oxygen species (ROS). While kleptoplasty is intriguing from an evolutionary perspective, there are many unresolved questions on how the algal organelle is incorporated into the metabolism of an animal cell and what the host-associated benefits are.  Aim: This proposal will unravel the cellular mechanisms supporting the sequestration and maintenance of functional chloroplasts inside metazoan cells and determine the host benefits of harboring kleptoplasts.  Approach: The expertise in keeping a variety of species will form the backbone of my state-of-the-art experimental strategy, comparing a wide range of different animal-alga associations in their response to chloroplast incorporation and variable ability to functionally maintain them. Lipidomic and transcriptomic analyses will unravel in a comparative approach the species-specific maintenance strategies underlying kleptoplasty. In addition, the impact of cytotoxic compounds produced by active kleptoplasts and in particular ROS production and scavenging will be explore. Finally, I will determine the fate of inorganic carbon and nitrogen to explore the contribution of photosynthesis-derived compounds to the physiology of the host.  Impact: This analysis will resolve some of the long
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A simple blood test for prognosis and monitoring of patients undergoing cancer therapy.' to be submitted under Horizon 2020.

assistant: **Abstract**

The objective of the ONCOCHECK project is to bring to the healthcare market a unique solution for cancer prognosis and monitoring which is a simple and inexpensive (<€200/test) blood test that will allow oncologists the prediction and evaluation of disease progression (monitoring) in patients affected by the great majority of cancers, with no distinction between haematological or solid tumors. The ONCOCHECK test is based on the determination of telomere length in peripheral blood, which is a blood cell marker that has been identified in the majority of cancers. The great advantage of the ONCOCHECK tests over any competing blood tests based on cancer tumor markers is that ONCOCHECK will serve for monitoring virtually all types of cancer, while competing tumor marker based solutions are useful only for a specific cancer/tumor. Therefore, Life Length´s test will offer a universal solution for cancer monitoring, with no competitors offering a similar approach.Considering the more than 35 million of people affected by cancer all over the world and that ONCOCHECK will serve for monitoring all cancer types, the business opportunity seems unquestionable. Through the ONCOCHECK project, we seek positioning our company as a leading player in the Advanced Next Generation Cancer Diagnostic Market, which was already  estimated globally to generate €7.1 billion in sales in 2015 and is forecast to exceed €13.1 billion by 2020. The main market drivers are the development of less invasive and less costly tools that can contribute to a more efficient, more frequent and sustainable management of cancer. In line with this, the ONCOCHECK project will offer oncologist a cost effective solution to the current challenges in regular cancer monitoring and management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated exposure management tool characterizing air pollution-relevant human exposure in urban environment' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The objective of the proposed cooperative research is the quantification of total human exposure from air pollutants and chlorine disinfections by-products of drinking water in several European urban areas. The environmental and policy-relevant products of the present proposal is the development of scientific methods in conjunction with a robust multiphase modelling environmental management system for facilitating more appropriate public health strategies for mitigation of the effects of air pollutants and drinking water to European citizens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Research on the behaviour and biology of a major African childhood malignancy, burkitt's lymphoma, and its associated virus, ebv' (1994-1998).

assistant: **Innovation**

* To seek a better prognosis for BL, based on clinical re-evaluation and reassessment of treatment, particularly for patients with non-responsive tumors, correlating patient data with molecular exploration of tumor tissue, and/or sera or whole blood analyses.* To establish new assays for diagnosis, some of which will be designed for use on site in Malawi, and analyzing viral (and cellular) gene expression, correlating data with clinical information.* To generate useful questionnaires regarding patient and family histories, as they may relate to onset of the disease, or the different individual clinical patterns observed, looking for possible genetic and/or environmental links to disease.* To explore viral markers that may have bearing on treatment of disease, aimed at correlation with clinical behavior. To build up a profile of EBV gene expression alongside patients data.* To train local personnel to help in management of the BL programme, both with regard to data collection, analysis, patient management and laboratory work.Expected Outcome* Data that lead to the re-evaluation of BL, and improved methodologies for correlating gene expression with patient prognosis.* New assays relevant to diagnosis and treatment of BL, and an overall better understanding of this major childhood tumor in sub-Saharan Africa.* Trained local personnel to work on BL projects in longer term.* Distribution of findings to other African countries where BL is a major childhood tumor, and publication of data as a means of distributing information further afield.* To establish an effective communications system among the partners, both with regard to exchange of data and of materials.* To train local personnel with respect to sample and data collection and interpretation, also with regard to labora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'PaaSage: Model Based Cloud Platform Upperware' (PaaSage).

assistant: **Innovation**

Cloud computing is a popular and over-hyped concept in ICT.  The concept of infinitely scalable elastic resources changing without complex systems administration and paying only for resources used is attractive. These benefits are not immediately realisable. Within-organisation benefits are realisable at considerable cost.  IaaS (Infrastructure as a Service) public CLOUDs have different interfaces and conditions of use thus for an organisation to 'scale out' requires considerable investment using skilled technical staff.<br/>The business need is to allow organisations to 'scale out' from their private CLOUD to public CLOUDs without a technical chasm between.  This cannot easily be achieved.  Aligned with the EU strategic direction of an open market for services, SOA (service-oriented architecture) offers a way to virtualise across heterogeneous public CLOUDs and organisational private CLOUDs.  It opens a market for European SMEs to provide services to be utilised (and paid for) by business applications and for all organisations to benefit from a catalogue of services that can be used across the environment.<br/>PaaSage will deliver an open and integrated platform, to support both deployment and design of Cloud applications, together with an accompanying methodology that allows model-based development, configuration, optimisation, and deployment of existing and new applications independently of the existing underlying Cloud infrastructures.  Specifically it will deliver a Cloud Application Modelling and ExecutionLanguage (CAMEL), an IDE (Integrated development environment), execution-level mappers and interfaces and a metadata database,<br/>The Consortium bring together ERCIM for management and STFC as scientific coordinator together with experts in different aspects of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Fluid mechanical stirring and mixing: the lagrangian approach'.

assistant: **Objectives**

Fluid flows enhance dramatically the transport of mixing of contaminants, tracers and particles. Understanding and controlling the dispersion of various species in a flow is a major objective for many important industrial and natural applications. The difficulty of the problem comes from the intricate nature of the underlying fluid flow, which involves many length scales, and from the lack of precise experimental knowledge about the motion of fluid particles. The field of turbulence, in particular in relation to mixing, has been recently the subject of very substantial progress. The development of new theoretical concepts, as well as of innovative experimental techniques permitting to follow tracers of fluid particles with a high resolution, open new prospects for the understanding of fundamental properties of tracer dispersion. The participants of the network have a unique expertise, and will pursue the investigation of fundamental studies in turbulent dispersion. The acquisition and the analysis of trajectories of individual tracer particles will lead to a completely new situation in this field. The results will be confronted to the results of theoretical and numerical studies. We are planning to apply the resulting insight to the crucial problem of modeling. In particular, we expect that the results should allow us to improve the numerous ad-hoc approximations used in models. We are planning to investigate in detail configurations of environmental interest, such as dispersion in seas or in the atmosphere, as well as of engineering relevance, such as mixing near a wall. New models will be tested in these demanding problems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spontaneous and sensory-evoked activity shape neural circuits in the developing brain' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

To generate brain circuits that are both flexible and stable requires the coordination of powerful developmental mechanisms acting at different scales. How does the brain prepare to efficiently compute information and reliably generate behavior during early development without any previous experience? A prominent transient feature of developing circuits is the ability to generate spontaneous activity before sensory organs mature. We know little about the detailed structure of this activity; however, blocking or perturbing this activity leads to miswiring defects, suggesting its powerful role in shaping local and brain-wide neural circuits. After the onset of sensory experience, ongoing activity continues to modify sensory circuits, and plays an important functional role in the mature brain. Together with advances in experimental techniques, we propose that theory and models are needed to establish a unifying framework of neural circuit development. Using quantitative data analysis, experiment-driven theory and computational modeling, we will derive key principles for how neural circuits are built and organized during early postnatal development into functional units, and how they are modified by intact and perturbed sensory-evoked activity. We will provide a quantitative analysis of longitudinal recordings of single neuron and network activity for the first time by synthesizing data from three collaborating labs. Our goal will be to reveal novel aspects of this activity that drive circuit refinement over a prolonged timescale during development, and to identify the powerful ways in which activity and circuit properties influence each other. Our models will generate and test hypotheses for how individual components affect different aspects of circuit organization during
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The one-stop-shop for urban and regional mobility' (MSH).

assistant: **Concept**

With cities mobility changing rapidly, new trends such as sharing-economy and smartphone penetration and challenges such as densification and pollution, commuters are dreading for solutions than can effectively integrate the diverse mobility landscape and improve their travelling experience. The Mobility as a Service (MaaS) concept is as such gaining interest as a solution to increase public and shared transport modalities and offer a smooth commuting. However, it also brings complexities as many different transport players and stakeholders have to be integrated. In response to that, we have developed Mobility Services Hub (MSH), a unique platform that provides the necessary interoperability to allow the different transport stakeholders to collaborate with each other. MSH’s platform combines all kinds of transport options from different providers and handles everything from travel planning to ticket booking and payments, reservations or billing services; and supplies reliable real-time data and incident information. Moreover, MSH will incorporate a Green Loyalty Scheme, a green-points approach to encourage and reward travellers for using eco-friendly transport modes, and health and safety services through a collection points approach. Our MSH pilot in Vienna – SMILE, was recognised as one of the most innovative projects in “The Future of urban Mobility 2.0”, in 2014.At MEP, we are experts in innovation in mobility and mobile payment. Together with our partner Fluidtime, a software developing company with over 10 years’ experience creating tomorrow’s mobility solutions, we envision cities that are smart, easy to live in and green. The global intelligent mobility market is estimated to grow from its current annual value of €57bn to over €1000bn a year by 2025, a staggerin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The geometrical and physical basis of cell-like functionality' to be submitted under Horizon Europe.

assistant: **Abstract**

Can systems with life-like properties be built from scratch with only a minimal set of components? While progress has been made experimentally in the development of such minimal systems, there is a lack of theoretical underpinnings that could provide mechanistic principles. My goal is to discover such principles by combining theoretical modeling and in-silico evolution to explore the potential for life-like functions of minimal systems consisting of only two core elements of cells: reaction compartments enclosed by lipid membranes (liposomes) and equipped with a protein reaction network. Towards this goal, we will develop new multi-scale approaches to investigate the mechanistic interplay between the ability of protein networks to form spatiotemporal patterns by decoding information about the membrane geometry and to reshape the membrane through mechano-chemical feedback. Using methods from differential geometry we will develop projection techniques that reduce the model to the two-dimensional manifold of the membrane. Building on my expertise with protein pattern formation I will design coarse-graining methods using machine learning concepts to link scales. These theories will give unprecedented insights into the relative role of reaction networks, membrane elasticity, and mechanochemical feedback in forming different types of protein patterns and membrane morphologies. Moreover, they will provide an efficient computational platform, which I will use to in-silico explore the potential of supported lipid bilayers with adhering liposomes as a platform to generate functions such as cell migration, cell division, and collective cell-cell communication. This will lead to theoretical insights into the mechanistic principles of the emergent behavior of these systems, make spe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Nanomaterials for conservation of European architectural heritage developed by research on characteristic lithotypes'.

assistant: **Objectives**

The project NANO-CATHEDRAL aims at developing, with a nano-metric scale approach, new materials, technologies and procedures for the conservation of deteriorated stones in monumental buildings and cathedrals and high value contemporary architecture, with a particular emphasis on the preservation of the originality and specificity of materials. The objective is providing “key tools” for restoration and conservation:•On representative lithotypes•On European representative climatic areas•With a time-scale/environmental approach•With technology validated in relevant environment (industrial plant and monuments)•Exploiting results also on modern stone made buildingsA general protocol will be defined for the identification of the petrographic and mineralogical features of the stone materials, the identification of the degradation patterns, the evaluation of the causes and mechanisms of alteration and degradation, including the correlations between the relevant state of decay and the actual microclimatic and air pollution conditions. Moreover, innovative nano-materials will be developed suitable for:•Surface consolidation: in this case water-based formulations based on nano-inorganic or nano-hybrid dispersions such as nano-silica, nano-titania, nano-hydroxyapatite, nano-calcite and nano-magnesia as well as their synergic combinations with organic and inorganic compounds will be considered. •Surface protection: in this case, innovative composites will be developed consisting of polymers and nano-fillers. The use of hydrophobins, nano-assembled hydrofobic proteins extracted from fungi, and  photocatalytic nano-particles (for favoring the decomposition of volatile organic molecules carried by polluted atmosphere and to prevent biofilm growth) will be considered.The project will co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Zero Emissions Platform supPORT secretariat' in the context of a Seventh Framework call.

assistant: **Objectives**

ZEPPORT (Zero Emission Platform supPORT secretariat) is the secretariat for the European Technology Platform for Zero Emission Fossil Fuel Power Plants (ETP-ZEP). It is the continuation of the previous secretariat that operated between 2006 and 2009 under the name “ZEST"" and between 2009 and 2011 under the name ""ZEPPOS"".The objective of ZEPPORT is to provide the level of support to ETP-ZEP that it needs for achieving its own goal: to enable commercial availability of technologies for CCS (Carbon Capture and Storage).Primarily ZEPPORT provides process support. This includes administrative activities but also organizational activities (initiate and structure ZEP-activities, networking activities and input for the discussions) and, if needed, fund raising and financial management. The process support is provided to the various bodies that make up the ZEP platform (the Advisory Council, Executive Committee, Coordination Group, Taskforces, Government Group and Temporary Working Groups).The increasingly important role of Member States, as a consequence of CCS (and ZEP-activities) moving into the demonstration and implementation phase, gets specific attention in our approach. ZEPPORT also provides communication activities for the intra-platform coordination of activities and the dissemination of information. Further, ZEPPORT manages and supports the recently established ZEP-C whose responsibility is the external communications.ZEPPORT is staffed by 3 people, all of which have worked for the ZEP secretariat during its first years of existence. ZEPPORT and its staff  members are independent from participating organizations and constituent groups (industry, NGO’s, research) and is therefore without vested CCS-related interests. The home base of ZEPPOS is The Hague, Netherlands