RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Development of a new method to increase the degrees of freedom of myoelectric upper-limb prostheses and construction of a new neuromuscular model to improve their controllability'.

assistant: **Objectives**

Prostheses are artificial replacements of body parts that have been removed, e.g., by amputation following a traumatic event or a disease. Currently, three types of prosthetic hands are commercially available;- cosmetic: passive devices with a simple aesthetic purpose,- body-powered: powered and controlled by body movements, generally by shoulder or back muscles, and- myoelectric: electrically powered and controlled by electromyographic signals, which are the weak electrical signals produced by contracting muscles.These devices are still too simple to mimic the functionality of the natural lost limb because they have only one or two degrees of freedom (d.o.f.s), which allow a very limited variety of movements. In addition, their control is just in o n/off or in simple proportional mode, which is quite far from the natural way of controlling movements.On the contrary, robotics hands are highly sophisticated devices with several d.o.f.s; however, they are unsuitable as prosthesis due to their rather bul ky size and control complexity. The aim of this multidisciplinary project is to construct an innovative type of myoelectric prosthetic hand bearing a superior functionality and a simple controllability, providing upper-limb amputees with a device that will be the closest ever reached to the real human hand.To this end, a highly innovative biomimetic interdisciplinary approach will be used:- a novel model of the human neuromuscular system will be constructed using system identification tools to obtain a m ore natural movement and control of the fingers;- a powerful statistical technique (ICA) will be employed to increase the number of controlling signals obtained from the muscles of the subject's stump and thus the number of d.o.f.s, highly increasing the variety of movemen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Oocyte Biology Research Innovation Training Net' under Horizon 2020.

assistant: **Concept**

The hallmark of successful mammalian reproduction is the fusion between a haploid spermatozoon and a metaphase II oocyte. The generation of such an oocyte involves a series of steps whereby germinal-vesicle oocytes (in which the nuclei are intact) at prophase I are stimulated to resume meiosis and mature to metaphase II, a sequence of events that prepares the oocyte for fertilization. Although the treatment of infertility by Assisted Reproduction Technologies (ART) has been increasingly successful, the efficiency remains low with only about 1 in 10 eggs retrieved from women undergoing infertility treatments healthy enough to produce a pregnancy and birth. In healthy fertile livestock species, where ARTs are applied for production purposes this number increases to 1 in 6 eggs retrieved, which is still remarkably inefficient. The greatest block to advancement, is the substantial lack of knowledge on the key regulatory checkpoints and processes that determine oocyte health. Such knowledge is key not just to treating infertility and maximising livestock genetic potential and productivity, but also to the field of regenerative medicine, where the reprogramming potential of the oocyte cytoplasm is critical to reprogramming somatic genomes.  The EUROVA ETN will train a consolidate European Oocyte Biology Research, train a new cohort of Reproductive scientists and  generate new knowledge. A deeper knowledge and understanding of the mechanisms set in place during the trajectory of oocyte growth, maturation, fertilization and oocyte to zygote transition will lead to innovations in ART, animal breeding, endangered species preservation, regenerative medicine and reproductive toxicology.


**Keywords:** Fertility, Oocyte, Embryo, Reproduction, Ovulation, Oogenesis, Oocyte developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Investigation of Novel biomarkers and Definition of the role of the microbiome  In Graves’ Orbitopathy (INDIGO).' (INDIGO) targeting Seventh Framework.

assistant: **Abstract**

Graves' orbitopathy (GO), also known as thyroid eye disease, affects approximately 3 million people in Europe with an estimated socioeconomic burden of 6.4 billion euros per annum. GO is a complication of Graves' disease which is an autoimmune disease and the commonest cause of an overactive thyroid gland. The treatment of GO remains unsatisfactory and the majority of patients report long-term impairment of quality of life. To improve the outcomes of people with GO and thus reduce long-term illness and cost to society, research is needed to address the identification of risk factors, develop a better understanding of the pathophysiology of the disease, devise approaches for early diagnosis during the pre-clinical stage of the disease, and create novel and safe interventions. INDIGO will refine and optimise animal and in vitro models of Graves’ disease and GO, which are urgently required to facilitate the study of the pathogenesis of GO. INDIGO will address the identification of risk factors for the initiation and perpetuation of autoimmunity that causes disease, using the latest generation technologies to study variations in the microbiome in Graves and GO patients and controls. The interaction of the gut derived antigens, from micro-organisms and nutrients on the autoimmune response in both the animal model by probiotic and “contra-biotic” intervention. State of the art technology will be used to search for biomarkers that will identify patients that will progress to GO, during the preclinical phase of the disease when intervention is most likely to be successful. The successful completion of the project will be ensured by a partnership involving 2 SMEs, 3 academic institutions and the European Group on Graves' Orbitopathy, each contributing complementary expertise and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'advanCEd REar end Structural test program – low level tests' (CERES), addressing dissemination and exploitation.

assistant: **Impact**

CERES aims to develop and execute innovative testing solutions to conduct the test program for the coupons level tests. The outcomes of this project will enable to demonstrate the feasibility of novel design concepts, materials and processes for Advanced Rear End (ARE). Ultimately, the validation of these new concepts will contribute to the development of a highly integrated rear end offering lighter weight and improved mechanical performance pursued by LPA IADP Work Package 1.2. The project will be carried out in a 34-month time span.


**Keywords:** Structural testing, advanced rear end, innovative monitoring methods, augmented reality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Industrial novelty dampers by development of advanced materials with high performance under electromagnetic rheological stimulation (IND-DAMPERS)' (IND-DAMPERS).

assistant: **Concept**

The project addresses the distributing vibrations to man, machinery and structures for reasons of safety, comfort, reliability and for gaining a competitive edge, as it aims at developing a generic technology for the manufacture of purpose-oriented high-performance magnetorheological materials, and to demonstrate their validity through the design and construction of semi-active, real-time controllable dampers. When successful, these innovative systems could be widely used. These dampers require little energy to operate and are by definition fail-proof since in case of failure a passive component is always present. The work will encompass defining the semi-active requirements, proceed over numerical modeling and prototype development to a phase of up-scaling and performance validation.- Semi-active magnetorheological (MR) damper for high speed trains;- Semi-active MR force limiter for civic structures and seismic protection;- Semi-active MR dampers for motorcycles and scooters;-Techniques and algorithms for MR semi-active control;- Semi-active MR valve for aircraft;- Thixotropic magnetorheological fluids, with improved sedimentation stability, based on silicone or mineral;- Mineral oil based magnetorheological emulsions with wide range of viscosity, for low viscosity applications;- Method for producing compound particles with enhanced ferromagnetic properties to be used in MR-fluids;- Method for producing polymer coated ferromagnetic particles for magnetorheological fluid;- Method for measuring sedimentation rate of magnetorheological fluids;- Method for measuring viscosity of magnetorheological fluids in magnetic field;- Magnetorheological solids based on millable rubbers;- Magnetorheological solids based on two component systems;- Magnetorheological solids based on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrative water sampling for the detection and identification of antiandrogenic contaminants in European rivers' in the context of a Seventh Framework call.

assistant: **Objectives**

Endocrine disrupting chemicals (EDCs) are environmental contaminants which have the potential to disrupt the normal functioning of the neuroendocrine system in animals and so result in physiological dysfunction. The effects of EDCs on wildlife and their potential effects on human health are a major concern to the scientific community and public. In Europe, EDCs with estrogenic activity are prevalent in effluents from wastewater treatment works (WwTWs), and may result in feminization of male fish in downstream waters reducing their fertility. Most recently, studies have shown that WwTWs effluents contain high concentrations of antiandrogenic activity, but unlike estrogenic chemicals, the identity of the antiandrogenic contaminants is currently unknown. This project aims to identify the antiandrogenic contaminants in WwTWs effluents using passive sampling techniques to obtain an integrative extract of contaminated waters over time. Antiandrogens in effluent extracts will be identified by bioassay-directed fractionation using a combination of in vitro androgen receptor assays and mass spectrometry analyses. Once identified, the range of concentrations of key antiandrogenic chemicals in river waters will be determined using integrative passive sampling of sites upstream and downstream of effluent discharges. This project will provide a more informed knowledge of the range of EDCs in river waters. The work will contribute to environmental impact assessments of these new and emerging environmental chemicals and have importance in the regulation of discharges, and thus is of very wide interest to the government regulatory bodies, environment protection groups, industry and the wider public in Europe. The project will bring Dr Liscio to work with Dr Hill, and allow her to benef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genomic instability and genomic alterations in pre-cancerous lesions and/or cancer' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

GENINCA will address two tumor entities, for which we have good access to pre-malignant lesions and in which genomic instability is a common feature: colorectal and liver cancer. Colorectal cancer amounts to 13.2% of all incident cases of cancer, the second most common form of cancer, surpassed only by lung cancer (13.3%). Liver cancer accounts for about 2% of total cancers, however, the most common liver cancer, i.e. hepatocellular carcinoma (HCC), is among the most lethal form of cancer, and its incidence in Europe has been steadily rising over the last few decades. GENINCA represents a collaborative study of 8 academic and 3 industrial partners from 5 European countries. GENINCA will focus on exploring pre-cancerous and cancer lesions of the two aforementioned tumor entities and their respective microenvironment. As the recent identification of human colon-cancer initiating cells by one of our academic consortium members paves the way for completely new strategies for studying mechanisms of tumorigenesis, a particular focus of this grant proposal will be the detailed characterization of these cancer initiating stem cells. At present, it is still a matter of debate which genomic changes are already present in precursor lesions and whether these lesions already show genetic instability. We will therefore address the occurrence of genomic instability and explore their underlying mechanisms especially in pre-cancerous and early cancer lesions. This will be greatly facilitated by in vivo endomicroscopy approaches, sophisticated animal models and large-scale genomic and proteomic analyses. Furthermore, we will include an in-depth analysis of the corresponding microenvironment. As this represents a translational research effort, we expect to identify markers for novel thera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Determination and measure of transport and mixing at the tropopause' (DEMETRA) under Sixth Framework.

assistant: **Objectives**

The transport and mixing occurring across the tropopause is a fundamental mechanism determining atmospheric and climate dynamics. Examples of phenomena affected by tropopause exchange include water vapour distribution (and thus weather patterns), greenhou se gases vertical distribution, ozone depletion, and fate of pollutants like airplanes exhausts. Many mathematical tools are available for extracting from wind datasets transport and mixing information, but when applied to the tropopause and compared with tracer profiles often provide conflicting answers. This is due to the fact that the tropopause is a complex, active interface, and hence each method only unveils one aspect. This project proposes to integrate several methods for studying the exchange event s occuring at the tropopause. The outcome of this approach will be used to explain tracer profile observed in tracer measurements of airborne missions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Production of Fibreboard Through High-Speed Refining, Double-wire Pressing & High-Level Intelligent Control'.

assistant: **Innovation**

Objectives and content The objective of PROFILE is the development of an optimised process for the production of fibreboard. It will minimise the use of resources (wood, energy) and environmental impact. The fibreboard produced with this new process will be an environmentally friendly superior quality product based on renewable resources. Due to the high quality of the end-product, PROFILE has the potential to substitute plastic materials by a natural wood fibre product in the automobile industry (moulded internal parts) as well as drill base plates in the electronic industry. It will allow easy non-polluting disposal and recycling of the product after usage. PROFILE will improve the fibreboard production process by: - reducing the electrical energy for dewatering by more than 60%; - increasing the dryness after mechanical dewatering to about 50% as opposed to the present value of 30%-35%; - reducing the thermal energy by more than 20%; - reducing pressing time and therefore increasing throughput by between 20% and - improving the quality of the plate. PROFILE will achieve its objectives by designing and building: - A new Refining Process. Through the use of high speed refiners operating at 3,000 rpm under very strictly controlled conditions, a reduction of 20% mainline energy consumption will be achieved without decrease in fibre quality. - A new Dewatering Process. The use of double wire pressing instead of a conventional Fourdriniere machine will lead to increase in dryness, and thus larger throughout, reduction of electric power consumption (through elimination of the vacuum pumps), a decrease in the thermal energy requirement and an improvement in plate quality. - A new Control Process. Total control to guarantee high quality at the new operating conditions will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Developmental Basis of Beak Shape Variation in Darwin’s Finches' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Darwin’s finches display an extremely high beak shape diversity associated with occupation of various ecological niches. They are the classic textbook example of adaptive radiation under natural selection. The supervisor of this proposal – Dr. Arkhat Abzhanov and colleagues previously used a combination of morphometrics, comparative developmental genetic and functional tests to reveal basic principles underlying beak shape morphogenesis. They showed that the enormous beak diversity in Darwin’s finches could be reduced to three “group shapes” (A, B, and C) and revealed molecular mechanisms causing the scaling–based variation within group “A”, but not yet the processes underlying the more complex shear-based saltational transformation that produced variation between groups. The main objective of this project is to identify the developmental programs underlying the leaps of beak shape diversification during Darwin’s finches’ adaptive radiation – the variation between “group shapes”. I will employ an extensive whole-transcriptome sequencing (RNAseq) screen to search for novel transcripts whose gene expression is associated with the group shape-specific beak curvatures. This will be complemented with genome-wide association study (GWAS) to identify upstream regulators of the actual effector molecules that cause the phenotype. I will validate the best candidates by gain- and loss-of-function tests using retroviral vectors on developing chicken and zebrafinch embryos to reveal their roles in beak morphogenesis. This project will provide novel insights on intrinsic mechanisms that facilitate adaptive morphological diversity, will offer an opportunity for interdisciplinary research interactions and will generate resources valuable to the entire biological community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'BLUE ENERGY OFFSHORE INSTALLATION ACCELERATOR' (BLUE-X).

assistant: **Innovation**

Key principles of the Green Deal are to prioritise energy efficiency, develop a power sector based largely on renewable resources, to secure an affordable EU energy supply and to have a fully integrated, interconnected digitalised EU energy market. However, renewable energy scale up in Europe faces increasing resistance due to limitations in applicable land area and the willingness of local communities to have wind or solar parks close by. One possibility to resolve this issue is the usage of offshore space. Blue renewable energy sources such as offshore (floating) wind, floating solar (FPV), waves, tides and currents have a high and still unused potential to be explored. This is of particular importance in view of the current energy crisis and changing energy policy. For all offshore technologies, lengthy and expensive MetOcean, geophysical and environmental campaigns are needed, which slow down the upscaling of offshore renewables. The proposed Blue Energy Offshore Installation Accelerator (BLUE-X) will contribute to the Green Deal objectives and its related policies, in particular with regard to increasing the EUs climate ambition for 2030 and 2050, supplying clean, affordable and secure energy, mitigating natural hazards and preserving and restoring ecosystems and biodiversity. BLUE-X is an innovative Copernicus based solution for optimising and accelerating decision making for blue renewable energy projects in all phases, from planning to construction, operation and decommissioning. The heart of this solution is a cloud-based IT network of relevant Earth observation and MetOcean data streams that are combined in decision support tools for each phase. As a result, the planning and construction phase can be significantly optimised, thereby reducing costs, and require