RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Adaptive nanostructures in next generation metallic materials: Converting mechanically unstable structures into smart engineering alloys' (SMARTMET), addressing dissemination and exploitation.

assistant: **Impact**

The design of advanced high strength and damage tolerant metallic materials for energy, mobility, and health applications forms the engineering and manufacturing backbone of Europe's industry. Examples are creep-resistant Ni-alloys in power plants and plane turbines; ultrahigh strength steels, Al- and Mg-alloys for light-weight mobility and aerospace design; or Ti-implants in aging societies.Since the Bronze Age the design of metallic alloys rooted in trial and error, owing to the complexity of the physical and chemical mechanisms involved and the engineering conditions imposed during manufacturing. This traditional approach has two shortcomings. First, current alloys are not developed via systematic design rules but via empirical methods. This approach is time consuming and inefficient. Second, the increase in strength via traditional hardening mechanisms always causes a dramatic decrease in ductility, i.e., making the material brittle and susceptible to failure.SMARTMET aims at solving this inverse strength-ductility problem: The joint use of advanced synthesis and atomic characterization (expertise of PI) together with ab initio modeling (expertise of Co-PI) opens a new path to the design of next generation metallic alloys. The objective is to use these methods to identify and utilize strengthening mechanisms that allow to overcome the inverse relationship between strength and ductility. The key idea is to incorporate phases into alloys that are close or beyond their mechanical and thermodynamic stability limit. They undergo transformations under load acting as self-organized repair mechanism. SMARTMET contains risks and gains: (i) Mechanical stability through unstable phases includes the risk of material weakening but it may break the inverse strength-ductility prin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Economics of impacts' under Fourth Framework.

assistant: **Concept**

1. Provide tool for measurement of socio-economic impact of transport infrastructure investments and transport system improvements (structuring effects).2. Work carried out in five countries (France, UK, Germany, Spain, Finland).3. Scope in France (where research has already been carried out); refine models on basis of time savings and analyse possible dampening effects at national and regional levels.4. Scope in UK, Germany, Spain, Finland: provide a first set of models linking employment, value added and production, with explanatory variables at country or regional level amongst which transport infrastructure investments. %Compare socio-economic impacts in various European countries according to countries characteristics (population, density of population, GDP, size of the country, level of economic development ...).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Real time investigation of the solidification of metallic alloys by coherent synchrotron radiation imaging'.

assistant: **Concept**

The dynamics of the solidification process of Al-based alloys will be studied in situ" and in real-time by X-Ray Imaging. The influence of the growth defects on the solidification front will be investigated and the results compared to numerical simulations."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Identifying key axis to modulate CD8 T cell exhaustion and improve cancer immunotherapy'.

assistant: **Innovation**

Cancer Immunotherapy has revolutionized Clinical Oncology. Yet, CD8 T-cell exhaustion remains a leading cause of treatment failure. This hypofunctional program suppresses anti-tumor CD8 T-cell responses and is reinforced by a stable epigenetic program that prevents exhausted CD8 T-cells (Tex) from reverting to more functional states. Checkpoint inhibitors such as anti-PD-1 can temporally relieve some constraints on TEX and be curative. However, this approach alone does overcome the epigenetic restraints of exhaustion which likely explains the lack of long-term benefits in many patients. Combinatorial approaches are needed to achieve durable protection in more patients. Yet, an incomplete understanding of TEX biology has provided little rationale for relevant therapeutic interventions.    Recent identification of an “effector-like” subset of TEX (TEX intermediate; TEXint) that mediates the benefits of PD-1 therapy and partially escapes the epigenetic strains of exhaustion, has brought new therapeutic perspective. Indeed, manipulating key pathways related to TEXint cells formation such as the IL-2/Stat5a axis potentiates TEX responses to PD-1 blockade and partially reprogram these cells towards more durably protective cell states. These findings provide compelling proof-of-concept that targeting key pathways driving Texint cell formation can unlock new strategies to overcome exhaustion and bolster PD-1 therapy. Building on this novel concept, our proposal utilizes advanced murine models alongside molecular engineering, large-scale genetic perturbation tools (CRISPR), and single-cell multiomics to uncover and characterize new regulatory pathways for Texint cell development. Our goal is to unveil new strategies to improve PD-1 therapy and advance next-generation anti-cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The world’s first remote, automated training tool and autonomous diagnostics solution for independent and OEM car dealerships and automotive education centers' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

An average new car has more lines of code than Facebook and more micro-controllers than a fighter jet. Finding motor mechanics who understand complex electronics is a problem today. In the UK, for example, 80% of independent garages say they have trouble finding able technicians, and there will be an estimated 25,000 mechanics needed in the USA by 2020. This problem will intensify as electric vehicles (EVs) are increasingly on the road. Industry estimates predict up to 20 million EVs in circulation by 2020 . There is an urgent need for education and training to update technicians’ skills with EV technology. Automotive training is still mostly done the same way as decades ago: with a teacher in a training center using brand-specific training simulators. Our core innovation, the KG System, is a patent-pending hardware module that can connect to any car brand/model, plus a software platform and mobile app that connects instructors to technicians anywhere in the world. The instructor remotely controls the module to activate failure simulations on the cars that the technicians are training with - a breakthrough, highly scalable and practical coaching approach. KG Pro 2.0 will take our technology to a new level, with fully remote and autonomous training, and automated diagnosis, in line with sector trends and needs.The EU automotive aftermarket is currently worth €221Bn, with opportunities for new digital, automated and autonomous solutions. KG Protech is an award-winning startup based in the UK, France and Brazil. Our technology and subscription-based business model have been validated by our trial users: car manufacturers, car dealerships and automotive education centers. The main objectives of phase 1 are to refine our go-to-market plan, mitigate risks, and to plan and all
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'LOcal sound for a new MUSicality. Enhancing musical participation through a local sonic practice'.

assistant: **Innovation**

Participation in music-making has shown to produce cognitive and behavioural benefits, enhance social participation, and contribute to shaping both individual and collective identity. However, access to music-making is reserved for people who possess some level of specialised musical training. LOMUS aims at developing a pioneering method that uses easy-to-use Calabrian sounding objects as a tool for facilitating non-trained individuals' participation in music-making: it unlinks music-production abilities from specialised instrumental training to enable non-musicians to make music without requiring mastery of an instrument, of specific musical idioms and techniques. By combining ethnomusicology, contemporary music and community music studies, LOMUS provides a sophisticated understanding of a local sonic practice and investigates how this could inform the emergence of a new global practice for music-making that challenges public conceptions of musicality and of a musician. The research will: study the Calabrian sounding objects to understand how they contribute to shaping the musicality of the community and how they could contribute to creating new types of musicality; investigate contemporary music practices and strategies that can be used to include non-trained individuals in music-making; develop a new method that uses Calabrian sounding objects and contemporary music strategies to enable amateurs and non-trained individuals to make music. The resulting method will be relevant to different rural or urban communities and it can be used to explore elements of a communitys soundscape as an inclusive tool for music-making. LOMUS challenges established concepts and practices around music and musicality, promotes social innovation by initiating new ways of relating with othe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dynamical evolution of small galaxy systems' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Detailed available data on compact groups of galaxies still have to be fitted in a consistent cosmological context. Specifically, no comparison exists between the observed space density of compact groups and the predictions of cosmological models. I propose to use numerical simulations to estimate the formation rate and the current space density of compact groups based on my recent demonstration that these systems form in short-lived structures within rich looser groups. These properties are expected to be sensitive to the cosmological model chosen and so may discriminate between otherwise possible models. This proposal fits within a major project currently under way at the MPA which involves cosmological simulations on parallel computers including gas dynamics effects. I will use simulations run on a Cray T3E to be installed in Garching in early 1996. These simulations will allow me to understand the evolution of compact groups in a cosmological context and their relation to the origin and transformation of galaxy morphology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Smart systems for environmental pollution detection and biogas production based on cloud-connected silicon photonic and microelectronic hyperspectral sensors' (SYMPHONY) targeting Horizon Europe.

assistant: **Abstract**

Air pollution poses a great environmental risk to health, accounting for nearly half a million premature deaths each year in Europe. Biogas production is an enabling technology to achieve net-zero emissions, while accelerating the energy diversification in Europe. Both, air quality control and biogas production demand critical improvements in sensor technology. SYMPHONY will develop a new technology enabling the implementation of dense networks of cloud-connected, low-cost, portable and easy-to-use sensors, capable of multi-target detection for applications in air quality control, pollution monitoring, industrial process control and safety. SYMPHONY will address this challenge by making key developments in silicon photonics, neuromorphic circuits, artificial intelligence, integration, and packaging, while exploiting state-of-the-art silicon microelectronics for ultra-low power edge computing with artificial intelligence, and the connected sensor network for spatially-resolved analysis and prediction. The main focus of SYMPHONY smart sensors are gases related to the biogas production and gases that have been identified by the European Environmental Agency (EEA) as highly pollutant and contributing to the greenhouse effect, such as CO2, CH4 and NO2. SYMPHONY smart sensors will be validated in three different relevant scenarios: city pollution monitoring in Cyprus, process control and leakage detection in biogas micro-plants in multiple locations in Europe. With this ambition in mind, SYMPHONY has gathered a transversal consortium, comprising three academic institutions, two research institutes, four companies and two end-users, coming from seven different countries in Europe. The consortium covers the full value chain, including silicon photonics, neuromorphic circuits, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of p110alpha isoform of PI 3-kinase in oncogenesis and cellular senescence' to be submitted under Seventh Framework.

assistant: **Abstract**

Mammals have 8 distinct isoforms of PI3K. One of the key PI3K isoforms in cancer is p110a, as this isoform is extremely frequently activated by mutation. How p110a achieves this function is not clear, and my main aim is to investigate the role and mechanism of action of p110a in an oncogenic context,  to provide a comprehensive picture of the molecular events controlled by p110a, and to identify molecular pathways interacting with p110a signalling. This is anticipated not only to provide a better fundamental understanding of PI3K signalling but could also reveal potential new targets for intervention in cancer.  During the 7 months I have been in the Host Laboroatory, I have discovered that loss-of-function of p110a leads to a peculiar form of cell senescence, and a key aspect of my proposed work will be the further dissection of the underlying signalling mechanisms. This will be done by a detailed analysis of known players in cell senescence but also by carrying out a rescue screen, which provides a more unbiased approach. I believe that this is possible, as I have found that p53 RNAi can rescue the senescent phenotype, providing 'proof-of-principle' for this approach. In pararel, I will also investigate the cellular and organismal impact of the most prevalent p110a point mutation found in cancer, by making use of a new mouse line which carries a germline p110a H1047R point mutation in the kinase domain.  This post-doctoral period will allow me to be familiarized with advanced and unique approaches used by the Host Group, including gene-targeted mice and sophisticated cell biology. Other than widening my scientific horizon and allowing me to establish international contacts, this project will also widen my expertise in basic research to the field of tumor biology in wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Singularities' under Fifth Framework.

assistant: **Concept**

The conference Singularities. Literature - Science - Responsibility. The Humanities in the Context of European Educational Policy" refers to the measures currently being taken regarding educational policies at European universities. The humanities are in the process of being put under a high amount of pressure to standardise, which is appearing as debates on legitimisation and method, and which is increasingly determining the institutional framework as well as the direction of teaching and research.Starting with the study of literature, we hope to establish a link between these debates. This conference hopes to work out specific characteristics of literature, in order to tackle the questions of forms of institutionalising the structure of literature. Regarding the restructuring of scientific disciplines, the specific "knowledge of literature" and the position of the humanities will be investigated within the framework of the study of German literature."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design of environmental decontaminants using calixarenes' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main objectives are described as follows :* To design new calixarene derivatives containing aliphatic and alicyclic amines and mixed donor atoms (sulfur and nitrogen) in which the distance between the phenolic oxygens and the amine nitrogens (or sulfur) is increased (-CH2-CH2-instead of -CH2-) in order to :i) induce selective complexation with polluting cations (mercury, cadmium and lead) while reducing the accessibility of the phenol oxygens to interact with essential cations (Na+, K+, Ca2+, Mg2+);ii) use the protonated calixamines and thiocalixamines for anion complexation with polluting anions (AsO4-3);iii) investigate the hosting properties of the hydrophobic cavity for interaction with polluting chlorinated aliphatic and aromatic compounds.* To incorporate these macrocycles in solid supports (natural products of Latin America, alumina, polymeric frameworks) for the development of recyclable materials and in membranes for the production of sensors for the detection of inorganic polluting ions.* To put calixarene based decontaminants into action by testing their capabilities on polluted natural resources (water) and to compare them with the currently used ion exchange methods.Expected Outcome* Availability of recyclable solid materials for water purification of higher efficiency than the ones currently used based on the use of ion exchange systems.* The development of new sensors based on these new materials for the detection of toxic metal cations in aqueous medium.* Quantitative information regarding the amount of polluting agents in contaminated waters stored in a database prior and after treatment with new materials.The key activities involve :* Synthesis and characterisation of calixamines and thiocalixamines : phase transfer catalysis for the synthesis of d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Sustainable exploitation of bioactive components from the Black Sea Area traditional foods'.

assistant: **Innovation**

BaSeFood aims to promote sustainable development and exploitation of Traditional Foods containing emerging bioactive compounds with putative health effects in the Black Sea Region (BSR). The Consortium includes 13 partners covering the BSR, EuroFIR partners with experience on traditional foods and bioactive compounds at the pan-European level, and one representing 11 European Food and Drink Federations. The objectives of BaSeFood are: (1) To investigate the knowledge base of traditional foods of the BSR in order to identify those foods to be collected and analysed. (WP1).  (2) To define, characterise and collect nutrient and bioactive data for a subset of about 30 prioritised traditional foods using previously developed and validated EuroFIR guidelines and bioactive databases, with appropriate analyses (WP2).  (3) To carry out case human intervention studies (priority: cardiovascular disease protection), supported by intensive in vitro and in vivo laboratory tests, to address the requirement for supporting evidence in nutrition and health claims (WP3).  (4) To accurately map and describe the flow charts of BSR traditional foods preparation and processing, and determine bioactive retention at both laboratory and pilot plant scale in close collaboration with industry partners (WP4).  (5) To evaluate attitudes of processors and consumers in order to optimise and enhance the whole food chain for improved availability and health benefits of BSR traditional foods (WP5). (6) To widely disseminate results and findings in order to enhance awareness and sustainable development of traditional foods of the BSR for improved health (WP6).  The project objectives are entirely congruent with those of the call, and will serve to (a) make a significant contribution to the substantiation