RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Most Easy, Efficient and Low Cost Geothermal Systems for Retrofitting Civil and Historical Buildings'.

assistant: **Concept**

The solutions to apply the shallow geothermy will be different in function of the building type, the climate and the geological conditions of the underground, the geothermal system (drilling methodology, GSHE, grouting,..). The main objectives will be : -identify and where missing develop building blocks solutions in drilling (machines and methods), GSHE types, heat pumps and other renewable energy/storage technologies, heating and cooling terminals with the focus on every type of built environment, civil and historical;-generate and demonstrate the most easy to install and cost-effective geothermal energy solutions using and improving existing and new tools.In the area of shallow geothermy  of further innovations are needed to provide a pan – European solution base for all the parameter combinations. More efficient borehole heat exchangers and lower cost drilling methodologies/machines adapted to the built environment will be realised as improvement or innovation related to the previous projects. This approach will bring to a easy applicability in the building refurbishment presenting different constrains, to reduce the overall drilling cost in the given geological conditions, will to avoid replacement of heating terminals constructing modular high temperature heat pumps and hence to reduce the deep retrofit costs. The association with tools (DSS, APPs, etc.) will enable to find the best solution for each combination of building type/climate/geology y. Moreover, the design tools will reduce overall engineering costs, avoid design mistakes and form the basis for a major dissemination effort. Application tools will help the users for different practical aspects. Finally to help knowledge dissemination and formations of the future experts a pan – European network of centr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Exploiting big data and machine learning techniques for LHC experiments'.

assistant: **Innovation**

Large international scientific collaborations will face in the near future unprecedented computing and data challenges. The analysis of multi-PetaByte datasets at CMS, ATLAS, LHCb and Alice, the four experiments at the Large Hadron Collider (LHC), requires a global federated infrastructure of distributed computing resources. The HL-LHC, the High Luminosity upgrade of the LHC, is expected to deliver 100 times more data than the LHC, with corresponding increase of event sizes, volumes and complexity. Modern techniques for big data analytics and machine learning (ML) are needed to cope with such unprecedented data stream. Critical areas that will strongly benefit from ML are data analysis, detector operation including calibration and monitoring, and computing operations. Aim of this project is to provide the LHC community with the necessary tools to deploy ML solutions through the use of open cloud technologies such as the INDIGO-DataCloud services. Heterogeneous technologies (systems based on multi-cores, GPUs, ...) and opportunistic resources will be integrated. The developed tools will be experiment-independent to promote the exchange of common solutions among the various LHC experiments. The benefits of such an approach will be demonstrated in a real world use case, the optimization of the computing operations for the CMS experiment. In addition, once available, the tools to deploy ML as a service can be easily transferred to other scientific domains that have the need to treat large data streams.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sexual system and genetic diversity in Mercurialis annua: a patch-level test of the metapopulation model' (GENEDIVPATCH) under Sixth Framework.

assistant: **Objectives**

Plants show a wide variety of sexual systems. Part of this variation can be explained with the colonisation history and population dynamics. During colonization, the need for reproductive assurance selects for self-compatible monoecy (system with only herm aphroditic plants present in a population).When population size increases, factors like tradeoffs between investment in male and female function start to play a role, a level of inbreeding is decreasing and males can invade the population. In large, stable populations dioecy (system with separate female and male plants) is considered to be an evolutionary stable strategy.Such changes in sexual system will have also consequences for the genetic diversity, because with the lowering level of inbreeding the genetic diversity is increasing and the genetic differentiation among the populations is decreasing. Although, these predictions are implicit from the many theoretical studies, empirical evidence for them is still very poor.This project aims at testing the predicted association between the sexual system and genetic diversity. As a study species, Mercurialis annua will be used because it shows a unique variety of sexual systems from monoecy to androdioecy (where males coexist with hermaphroditic plants) and finally to dioecy. Androdioecious populations differ widely with the percentage of male individuals.We hypothesise that such fine-scale patterns of sex-ratio variation in M. annua are due to colonisation and patch dynamics at a small scale within sampling localities, and that these processes will be evident as signatures in the patterns of neutral genetic diversity.The percentage of males in a population will be correlated with the genetic diversity measured by means of microsatellite loci. Then a hierarchical popula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New Adaptive Computational Methods for Fluid-Structure Interaction using an Unified Continuum Formulation with Applications in Biology, Medicine and Industry' in the context of a Seventh Framework call.

assistant: **Objectives**

For many problems involving a fluid and a structure, decoupling of the two is not possible to accurately model the phenomenon at hand, instead the fluid-structure interaction (FSI) problem has to be solved as a coupled problem. This includes a multitude of important problems in biology, medicine and industry, such as the modeling of insect flight, the blood flow in our heart and arteries, human speech, acoustic noise generation in vehicles and wind induced vibrations in bridges and other structures. Major open challenges of computational FSI include; (i) robustness of the fluid-structure coupling, (ii) efficiency and reliability of the computations in the form of adaptivity and quantitative error estimates, and (iii) in the case of high Reynolds number flow the computation of turbulent flow. In this project we address (i)-(iii) by a novel approach which we refer to as a Unified continuum formulation (UCF), where we formulate the fundamental conservation laws for mass, momentum and energy for the combined FSI domain, which is treated as one single continuum, with the only difference being the constitutive relations for the fluid and the structure. The stability problems connected to FSI are related to the exchange of information (stresses and displacements) over the fluid-structure interface, but with UCF we achieve (i) by the global coupling of the conservation laws where the fluid-structure interface is just an interior surface. We achieve (ii)-(iii) by extending to FSI our technology for adaptive finite element methods for turbulent flow with a posteriori error estimation using duality. We typically discretize the equations using a Lagrangian coordinate system for the structure and Arbitrary Lagrangian-Eulerian (ALE) coordinates for the fluid. Preliminary results for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'WNT3A IN NEUROIMMUNE INTERACTIONS IN STROKE BRAIN' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

A stroke, or cerebrovascular accident, is the rapid loss of brain function due to disturbance in the blood supply to the brain. Ischemic stroke is currently the leading cause of adult chronic disability, the second most common cause of cognitive impairment and the third most frequent cause of mortality in industrialised countries. Consequently, it is presently of outmost importance to study, to understand and to characterize the etiopathological mechanisms underlying stroke.Neuroinflammation is undoubtedly linked to stroke and many other neurological disorders, since immune response impacts on the diseased nervous system modulating the progression of them. Neuroimmune interactions constitute an important part of this immune response and they seem to control several regenerative processes in the brain, including neurogenesis. This crosstalk is mediated by different molecules and among them, Wnt proteins have emerged as interesting modulators. We here propose to analyze the putative neuroprotective role of a specific immune-secreted Wnt subtype, Wnt3a, in stroke, as well as the effects of this ligand on adult neurogenesis processes.The project will include two different approaches: a first in vitro part to isolate, characterize and modify with lentiviral constructions Bone-Marrow (BM) derived cells in order to overexpress or to abolish Wnt3a expression. A second in vivo part to generate chimeric mice by transplantation into the brain of the previously modified BM derived cells.This fellowship will give important information on the role of Wnt3a in stroke as well as providing a powerful in vivo tool and will open direct leads for therapeutics. I will acquire a more complete and diversified scientific knowledge and technical preparation through a multi-disciplinary approach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biological, Individual and Contextual Factors of Fertility Recovery' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The age at which people have their children has increased tremendously since the 1970s in the low fertility countries. The reasons for delayed reproduction have been explored extensively, but very little attention has been given to the factors that facilitate and constrain fertility at later ages (from age 30). Yet, the desire and ability of those who did not have children in their 20s to have them later (“fertility recuperation”) is decisive for future fertility levels, and for life satisfaction among those who wish children. BIC.LATE will fill this gap by studying the biological, individual and contextual factors of later reproduction in the low-fertility countries, and possible catch-up behaviour of those who did not have a child earlier. In this new perspective, we will:1)Measure the effect of biological limits on fertility recuperation with contemporary data for women and men, accounting for changes in Assisted Reproductive Technologies;2)Identify the remaining individual factors of later fertility (demographic and socio-economic) among women and men, exploring factors more relevant at that ages (health, dedication to work);3)Understand to what extent the structural and cultural context of a country (e.g. policies, economic situation, social norms) matters for fertility recuperation in a comparative perspective;4)Estimate the link of these factors with fertility recuperation and draw cutting-edge meta-scenarios of cohort fertility. We will use data from social surveys (cross-sectional, panels) and aggregate cohort fertility data in Europe, the English-speaking oversea countries and East Asia, and data from a fertility clinic in Vienna. The research design includes survival analysis on panel data and on retrospective family history, aggregate correlations and cohort
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of novel rapid design methods for separation of enantiomers by crystallization: a process systems engineering approach'.

assistant: **Objectives**

Pharmaceutical industries face continuous challenges in terms of process development for new drug substances and product. Considerable amount of time and resources, both human and material, are spent on the engineering research, including the process, scale-up and control development for the promising molecules synthesized often in micro-gram scale firstly. Crystallization is a particularly important in the pharmaceutical industry as it links the drug substance (active pharmaceutical ingredient) and drug product (e.g. tablets, injectables etc.) manufacturing. Good operation of crystallization is not only important to achieve the desired yield, but the purity, polymorphism, chirality and also the particle size and shape strongly impact the performance of the drug product, e.g. the bioavailability, dissolution rate and, not rarely, the toxicity. Crystallization processes are currently being designed in pure experimental fashion, relying on the pharmaceutical Quality by Design (QbD), which undoubtedly moved and moves the pharmaceutical industry forward, but it has tremendous experimental burden. The digital era paws the way for competitive and often complementary computer aided process design techniques. The goal of this project is the development of novel process systems engineering methods that are suitable for rapid and robust-optimal crystallization process design. For experimental and simulation demonstration, to keep the simplicity without loss of generality, a challenging but frequently occurring pharmaceutical crystallization process will be considered: the preferential crystallization of enantiomers. For rapid experimental design, process analytical technology based feedback and feedforward control techniques will be developed as a direct alternative for QbD strat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A comprehensive multidisciplinary study on the epidemiology of the haemorrhagic fevers leptospirosis and dengue in central america' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Leptospirosis and dengue are easily confused because of their clinical resemblance. Both diseases, which are of considerable medical and economic importance, are emerging in Central America. The establishment of an international infrastructure, consisting of a sub-regional centre and national institutes, hospitals and health posts, is proposed to perform epidemiological survey in this area. The project is expected to provide(a) the backbone for a future surveillance network for haemorrhagic fevers,(b) laboratory tools for diagnosis and characterisation of causative agents,(c) a system for international data handling and exchange,(d) knowledge of circulating types and servers,(e) identification of leptospiral infection reservoirs and risk factors for Dengue Haemorrhagic Fever, and(f) a rational design of control and prevention measures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Algorithmic Foundations of Geometry Understanding in Higher Dimensions' (GUDHI).

assistant: **Innovation**

The central goal of this proposal is to settle the algorithmicfoundations of geometry understanding in dimensions higher than 3.  Wecoin the term geometry understanding to encompass a collectionof tasks including the computer representation and the approximationof geometric structures, and the inference of geometric or topologicalproperties of sampled shapes.The need to understand geometric structures is ubiquitous in scienceand has become an essential part of scientific computing anddata analysis.Geometry understanding is by no means limited tothree dimensions. Many applications in physics, biology,andengineering require a keen understanding of the geometry of a varietyof higher dimensional spaces tocapture concise information from the underlying often highlynonlinear structure ofdata. Our approach is complementary to manifold learningtechniques and aims at  developing an effective theory for geometric andtopological data analysis.To reach these objectives,  the guiding principle will be to foster asymbiotic relationship between theory and practice, and to addressfundamental research issues along three parallel advancingfronts. We will simultaneously develop mathematical approachesproviding theoretical guarantees, effective algorithms that areamenable to theoretical analysis and rigorous experimental validation,and perennial software development.  We will undertake thedevelopment of a high-quality open source software platform toimplement the most important geometric data structures and algorithmsat the heart of geometry understanding in higher dimensions. Theplatform will be a unique vehicle towards researchers from otherfields and will serve as a basis for groundbreaking advances inscientific computing and data analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Tracing the carbon and water cycle in terrestrial ecosystems with stable isotope spectroscopy' (ISOCYCLE).

assistant: **Innovation**

Understanding the processes and mechanisms that control carbon and water flow through terrestrial ecosystems is essential both to estimate the current capacity of terrestrial ecosystems to absorb carbon from the atmosphere and to predict the ecosystem's responses under a changing climate. Stable isotopes of carbon and oxygen provide a powerful tool to trace the flow of carbon and water through ecosystems and to elucidate the interplay between various ecosystem compartments. So far, stable isotope research has been restricted to discontinuous field sampling due to laborious flask sampling and expensive lab analysis.With this project we propose to build one of the first laser spectroscopy facilities for stable isotope ecology research in Europe based on a newly developed laser spectroscopy technology from the USA. Based on these laser systems for continuous stable carbon and oxygen isotope measurements together with the eddy covariance technique and chamber systems we want to (a) quantify a complete stable carbon isotope budget of an ecosystem in the field, (b) trace the flow of carbon from the atmosphere through the plant to the soil via isotopes in natural abundance and isotope labelling, (c) link the carbon and water cycle at ecosystem level, and (d) study the impact of climatic extreme events, such as drought, on the carbon flow. The project will combine observational fieldwork with manipulative drought experiments and ecosystem scale modelling.This project will complement research activities at the host ETH Zürich and will integrate into European carbon cycle projects. Findings from this project are expected to contribute to a better mechanistic understanding of the terrestrial carbon sink in Europe and of its response to climatic extreme events.