RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '10 Years of Hercules Euroconference' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The HERCULES Course is designed to train young European researchers, either Phd students or post doctoral scientists to optimise their use of the Large Installation (L.I) of neutron (n) and synchrotron radiation (S.R) for studies in the fields of Solid State Physics and Chemistry, Structural Molecular Biology, Materials Science, Geoscience and Industrial Applications. Since its inception in 1991, the principal emphasis of this course has been placed on laboratory practicals carried out in four partner L.I. (ESRF, ILL, LURE, LLB), accompanied by tutorials and lectures. The need for such a training at a European level has been clearly expressed: at the end of the 1999 session, about 650 European young researchers will have attended the course, out of 1200 applicants, with the permanent financial support of the CEC (Science, HCM, TMR).One of the aims of HERCULES was to help build a European network of young researchers using n. and S.R. for condensed matter studies. In this context, on the occasion of the 10th anniversary of the Course, we wish to reactivate the links and reinforce the contacts between the past HERCULES participants by organizing the HERCULES X EuroConference at the end of the normal HERCULES 2000 sessions. The main objective of this EuroConference is to bring together all the HERCULES participants (past and HERCULES 2000 sessions) and high level lecturers on challenging topics and highlights related to recent developments and applications of n. and S.R. in the multidisciplinary fields covered by the Courses. The organizers will do their best to magnify, as far as possible, the scientific exchange between all the attendees (HERCULES participants, invited lecturers, ESRF and ILL permanent scientists) via oral contributions, poster sessions, clips and round
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Linking Latin. Building a Knowledge Base of Linguistic Resources for Latin' in the context of a Horizon 2020 call.

assistant: **Objectives**

Although the research area dealing with building, sharing and exploiting linguistic resources and tools for automatic processing of Latin (and, more generally, of ancient languages) has seen a large growth across the last decade, linguistic resources for Latin are still not interoperable. This means that linguistic information is split up in many products that just do not talk to each other.Such a situation results in poor exploitation of the richness provided by all those digital objects for Latin that were produced across years of work. Since Latin is a dead language (thus missing native speakers), all we can and must do is to exploit to the best the information contained in those few and precious texts that survived from the past. This means:- to make the best possible organization and use of the available linguistic resources for Latin (enhanced with web-services for Natural Language Processing – NLP –) for a fruitful integration of the information they provide, i.e. to retrieve and combine information from different sources in the most efficient way;- to make it available linguistic resources whose quality is assessed (curated data sets).The objective of the LiLa project is to connect and, ultimately, to exploit the wealth of linguistic resources and NLP tools for Latin assembled so far, in order to bridge the gap between raw language data, NLP and knowledge descriptions, thus enabling scholars to exploit to the best the currently available resources and tools.To address such a challenge, LiLa intends to incorporate the linguistic resources for Latin into the Linked Data framework, making it possible for them to be published and interlinked on the web and to interact with each other. To this aim, the project will build an open-ended knowledge base for Latin by usin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Proactive synergy of inteGrated Efficient Technologies on buildings’ Envelopes' (Pro-GET-OnE) under Horizon 2020.

assistant: **Objectives**

The innovative aspect in Pro-GET-OnE (Proactive synergy for Greater Efficiency On buildings’ Envelopes) consists in the following holistic vision: To combine in a same integrated system based on pre-assembled components the highest performances (iii) in terms of i) Energy requirements – by adding (or substituting the existing with) new prefab and plug and play high energy performing envelopes ii) Safety – by using appropriate steel structures to reduce horizontal loads and implementing the structural safety while supporting the new envelopes (timber for opaque parts/surfaces, glass, PV and solar panels)iii) Social sustainability – by ensuring tailored and customized solutions for users and increase the desirability of retrofit options.Building upon the previous experiences, Pro-GET-OnE aims at promoting a holistic optimized approach that goes beyond the results of EU and national projects and the IEA report on Prefabricated Systems for Low Energy Renovation of Residential Buildings.In fact, PRO-GET-ONE proposes the highest transformation of the existing building’s shell with volumetric increase and buffer zones (i.e. sunspace between the building and the outdoor environment, extra room, etc.). These solutions have been designed and analysed in a large set of existing buildings.Being the openings guaranteed, this solution would efficiently provide an effective zone to reduce thermal losses in the cold winter season while ensuring shadow during summer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Unraveling the role of transgenerational epigenetic inheritance mediated by paramutation in natural animal populations.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Understanding how organisms rapidly adapt to changing environments is a fundamental question in evolutionary biology. Transgenerational epigenetic inheritance (TEI) has been proposed as a mechanism that allows organisms to respond flexibly to environmental variation and thus plays a central role in rapid adaptation to fluctuating environments. A compelling example of this process is paramutation, in which epigenetic information is transferred from one allele to another, leading to heritable changes in gene expression across generations. However, our understanding of paramutation in natural animal populations remains limited, with most evidence coming from laboratory models. This knowledge gap hinders our understanding of the role of paramutation in nature.Here, we will study paramutation in different natural populations of Drosophila melanogaster to investigate its potential to drive transgenerational epigenetic inheritance and gene expression variation that can shape evolution. We will investigate the responsiveness of paramutation to environmental changes and its heritable stability across generations. We will also establish a model to dissect the molecular mechanisms of paramutation regulation, assessing the role of insulator proteins such as Su(Hw) and 3D chromatin conformation. This project will provide a comprehensive investigation of the role of paramutation in natural animal populations at multiple levels of information, including genetics, epigenetics, gene expression, and 3D chromatin structure.This research proposal aims not only to determine the biological relevance of a case of transgenerational epigenetic inheritance such as paramutation in natural animal populations but more importantly to provide an excellent model system for its in-depth molecular disse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European network for the advancement of clinical gene transfer and therapy' (CLINIGENE), addressing dissemination and exploitation.

assistant: **Impact**

The field of gene therapy has matured and the prospects are exciting and hopeful since some treatments have now been shown to be effective in the clinic. However, precise quality and safety standards for clinical gene transfer have yet to be defined. Defining optimal methods for the production of standard vector systems would pave the way for accelerated development and improved safety. This would be of enormous value to industry, individual investigators and regulators.The NoE goal is the creation of a European Network for the Advancement of Clinical Gene Transfer and Therapy (CLINIGENE) integrating multidisciplinary research & development in gene therapy and mobilising all major stakeholders involved in the development of gene therapy medicinal products: academia, industry, regulatory bodies, clinics and patients. CLINIGENE will generate platform databases for particular vectors with respect to their safety and efficacy to ensure product manufacturing according to well-defined quality and safety standards in order to accelerate clinical trials. This will be achieved by compiling all available information and then ranking test and control methods by comparison and through validation by expert partners. The JPA comprises 1. Integration activites: sharing facilities, exchange and high-level training of personnel, e-communication, collaboration with the ESGT2. Research activities: 6 horizontal activities serving integration towards the generation of reference/standard profile data-bases - AAV, gamma-retrovirus, lentivirus, adenovirus, genetically-modified cells & non-viral vectors - & 4 vertical activities defining a path to optimised clinical protocols - quality and efficacy (manufacture), safety (pharm-tox and virus safety); pre-clinical models and novel assessment tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An innovative environmentally friendly gelcoating technology for composites for marine and wind-Turbine applications to reduce VOC emissions, processing time and cost' (INGECT).

assistant: **Concept**

Gel coats are applied to fibre-reinforced composite materials for aesthetic or protection purposes. Styrene is an essential part of these gelcoats, with ~25% of this released during possessing. These styrene emissions cause irritation and neurological effects as well as possibly being carcinogen. One of the biggest negative effects of styrene is the perceived odour both by the workforce and neighbourhoods. As a result styrene emissions are limited under the Solvent Emissions Directive.Although the adoption of closed mould technologies for the production of composite parts have gone a long way to reducing styrene emissions during manufacture, gelcoating must still be undertaken under open-mould conditions as no viable in-mould gelcoating technology is commercially available.We are developing an innovative in-mould gel-coating process, requiring minimal equipment modification (and therefore low capital expenditure) based on the innovative application of low-viscocity gelcoats and a spacer fabric. The proof-of-concept work undertaken to date has this technology has the potential to achieve significant benefits beyond the current state of the art to produce parts that are fit for purpose whilst reducing styrene emissions to <5ppm.The overall aim of the InGeCt project is to develop technical textiles and gel-coat formulations in combination with process design and optimisation that will enable significant reductions in VOC emissions whilst reducing production times by 18.5% and manufacturing cost by 10.5%. Our technology will therefore be very attractive to composites processors, giving significant economic and societal benefits to consumers and manufacturers. The SME consortium target a significant  penetration of the EU market within a 5 year period, achieving direct annua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Destabilization of the Epithelial Tissue Architecture by Competition with e-cadherin Homo-dimer formation: small molecule-induced disruption of the epithelium integrity and functions' (DETACH) under Seventh Framework.

assistant: **Objectives**

Cadherin expression on the surface of cells is critical for cell-cell adhesion and, consequently, for the development and the integrity of solid tissues. In mammals, impaired cadherin mediated adhesion has been implicated in all steps of tumor progression. E-cadherin, a prominent member of the cadherin family, is expressed on the surface of epithelial cells in the digestive tract, in the lungs as well as in the testis and other organs and is therefore responsible for the integrity of the mucosal tissues that protect a vast surface of the inner body. Cell adhesion mediated by E-cadherin and other type I cadherins involves homophilic “trans” interactions that are brought about by a strand exchange mechanism involving the N-terminal extracellular domain. The epithelial tissue constitutes the body’s first line of defense and, as such, is exposed to a large number of small, potentially toxic molecules from the environment whose chemical and structural features are reminiscent of the tryptophan residue (Trp2) used by E-cadherin in its dimerization mechanism. These molecules can mimic the Trp2 function in E-cadherin by inserting into the hydrophobic acceptor pocket of E-cadherin and by occuping the site of Trp2 docking, thus potentially interfering with the E-cadherin mechanism of self-adhesion. We hypothesize that such events can disrupt the integrity of the epithelial tissue, ultimately causing tissue remodeling and the loss of the epithelium’s protective properties. The main aim of this project is to use X-ray crystallographic analysis to determine whether a number of known environmental pollutants that are present in the atmosphere as well as in foods or other media to which the population is commonly exposed can bind into or in the vicinity of the E-cadherin hydrophobic p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Digital On-Line Pilot Project to Help Intermodal Networking & Short-Sea-Shipping' to be submitted under Fifth Framework.

assistant: **Abstract**

The aim of DOLPHINS project is to build an e-commerce platform where innovative telematic smart-maps can stimulate and facilitate new and existing business in short-sea-shipping. With these tools, based on low cost Intranet/Internet platform, people can remotely access information through an intuitive interface, linked to online database services and assistance. DOLPHINS will use on-line dynamic interactive smart-maps enable to provide intermodel solutions of transport.DOLPHINS is a new e-commerce system, where smart-maps have the purpose to:- combine booking, scheduling, negotiation, brokerage, payment and invoicing data in a timely and effective manner;- connect users (MTOs, transport operators, ship-owners, shipping companies, forwarders, SMEs, etc.) together and allow them to share dynamically.DOLPHINS will be a marketing instrument, extending the accessibility of user-friendly information to SMEs.Work description:Using smart-map technology, people can share and link multimedia information via time-sensitive animated maps. DOLPHINS employs low-cost internet/intranet TCP/IP platforms. An essential feature correlates time-series scheduling information with geographic/spatial and routing information. Remote users can access to this functionality easily using the world-wide-web.In the negotiation phase, which will be achieved by combining scheduling and impact on pricing, clients can have a first level of web-self-negotiation" according to their needs.The smart map can be seen as an on-line interactive web-site able to offer real-time convenient solutions for intermodal transport."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New mouse models for genetic deafness: a systematic approach to understanding the molecular and biological basis of deafness' (1994-1998).

assistant: **Innovation**

- A considerable number (around 35) of new hearing-impaired mouse mutants will be found from mutagenesis programmes. - All the new mutations will be localised at a low resolution and high resolution genetic maps will be generated for around 25 of these. - The development of auditory pathology will be investigated in those mutants which are of greatest interest (around 15).The objective is to double the number of known loci involved in non-syndromic deafness in mice, and to make significant steps towards identifying the responsible genes and understanding the pathological processes leading to hearing impairment. This will be done by adding a new screen for non-syndromic deafness to two large ongoing mutagenesis programmes. Around 35 new hearing-impaired mutants should be found in this way. All the new mutations will be mapped to a mouse chromosome at low resolution, to establish which are new loci and which may be new mutations of known deafness loci. A positional candidate approach to identifying the responsible genes will be initiated in around 25 of the new mutations by generating high resolution (<0.1 cM) genetic maps. Such detailed maps will enable the selection of suitable candidate genes for mutation screening from the rapidly-growing transcript map of the mouse genome. The development of the hearing impairment will be investigated in about 15 new mutants using electrophysiological measures of cochlear function combined with gross structural and ultrastructural study of the middle and inner ear. This information about the phenotype will indicate the cells or tissues which are first affected by the mutation, and help our choice of likely candidate genes for mutation screening, as well as provide a framework for interpreting the molecular basis of the defect when th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Using in-depth genomic knowledge to understand and Using in-depth genomic knowledge to understand and predict short- and long-term responses to climate change in a commercially targeted marine species' in the context of a Horizon Europe call.

assistant: **Objectives**

Making the most of genomic tools to understand and predict species response to global change is increasingly important, especially in exploited marine species. In EVOLOCT, I aim to determine the genomic basis of local adaptation, while understanding the past, present, and future population dynamics of Octopus vulgaris. This ecologically and economically significant species has recently expanded northwards in the northeast Atlantic, possibly due to climate change or human exploitation, yet the exact causes and the population stability remain unknown. Moreover, while the importance of structural variants (SVs) has been increasingly recognised in underlying ecotypes and cryptic population structures, SVs remain poorly represented in eco-evolutionary studies. To address these gaps, I will integrate modelling, genomics, and environmental data to characterise present population structure and dynamics, reconstruct their demographic history, and predict their future distribution, abundance, and vulnerability. Pushing the boundaries of current genomics studies, I will incorporate SVs beyond the classic SNPs while combining simulated data with empirical data, as a powerful and comprehensive technique in predicting short- and long-term responses to climate change. I will hone my skills at the host lab of Dr Mérot alongside Prof Charrier and Dr Le Luyer, French experts in evolutionary biology and ecology. My secondment with Asst Prof Oomen in Sweden will expand my skills in modelling and SV analyses. Through these collaborations, I will learn new multidisciplinary approaches and techniques in modelling and genomics. EVOLOCT will undoubtedly enable me to gain a competitive advantage in establishing my career in the dynamic and critical field of evolutionary ecology. Finally, EVOLOCT