RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Trans-Sialidase of Trypanosoma Cruzi: Analysis by molecular dynamics and QM/MM methods of the reaction and the ligand affinity of a potential drug target' in the context of a Sixth Framework call.

assistant: **Objectives**

The trans-sialidase of Trypanosoma Cruzi (TcTS) has been identified as a potential target to fight the Chagas disease, which affects 16-18 million people in Latin America and lacks an effective cure. No effective inhibitor is known for TcTS. Therefore, a de tailed understanding of its mode of action and the associated energetics is of interest and could help the design of such an inhibitor. We propose to perform this study by computational means in tight collaboration with the crystallographic group in the Institute Pasteur (P. Alzari) to further exploit their data.On the one hand, we will analyse the contribution of different residues and ligand moieties to the binding affinities. For that, it appears important to take ligand and enzyme relaxation, as well as explicit solvent molecules into account because the recently solved high- resolution crystal structures have revealed conformational switches along the reaction and flexibility of the active site. We will use a molecular dynamics-based free energy method recently developed in the Pasteur Institute group, which fulfils these requirements and has predicted mutation effects with similar accuracy as the experiment. Furthermore, we propose to analyse the binding properties of new molecules made up of moieties taken from known ligands in order to attempt to identify the combinations giving tighter binders.This novel computational approach will, if successful, become a very valuable tool in other projects. On the other hand, we will study the chemical steps leading to the formation of a glycosyl-enzyme covalent intermediate allowing the trans-sialidase function whilst preventing the hydrolysis (sialidase function). A quantum mechanics/molecular mechanics potential will be used to understand how the enzyme forms this cova
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Variable Compression Ratio System for the reduction of fuel consumption and CO2 emissions in motor vehicles' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Increasingly stringent emission and fuel economy standards have been pushing old combustion engines into an accelerated evolution phase. In this context, OEMs in the industry have shifted their R&D efforts towards more thermally efficient, less polluting and down-sized engines, thus viewing the production of low emission and fuel consumption vehicles. The concept of VCR engines (i.e. the compression ratio (CR) of the internal combustion engine can be modified under dynamic driving conditions and performance needs) has been considered as an essential future technology to meet these targets. However limitations associated with their effect in engine’s architecture, their impact on the reduction of CO2 emissions and additional productions costs have hindered their widespread commercial application.Our ground-breaking VCR system will be the first able to address the burning needs of the industry. Gomecsys VCR system is a highly innovative system differentiated from alternatives due to its engineering simplicity able to significantly enhance the performance of conventional combustion engines achieving a staggering 5-10% reduction on fuel consumption and CO2 emissions. Our core aim is to commercialize the 6th generation of our VCR system in 2020 and its commercial viability will be based on our ability to define business opportunities in target markets and attract key partners and customer OEMs for our project. Moreover, we are convinced that our project will provide “resource efficient transport that respects the environment” which is considered a critical aspect to meet “Smart, Green and Integrated Transport” societal challenge addressed by Horizon 2020 programme.Finally, through the completion of Gomecsys VCR system project we expect to reach €15 million revenues five year
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enhancing the capacities of the ELIRI Research Institute in applied research to enable the integration of Moldova in the European Research Area on the basis of scientific excellence' (MOLD-NANONET).

assistant: **Innovation**

The objective of MOLD-NANONET is to assist the ELIRI Research Institute to develop and implement a research strategy that will expand its activities and increase its level of excellence in micro-nano-electronics related to the development of intelligent systems, so that it can compete and collaborate with leading research institutions in Europe. MOLD-NANONET will create a unified infrastructure in Moldova by integrating the R&D capabilities of the city of BELTI with those of the capital city (Chisinau). Training activities will be opened up and integrate with activities in other relevant research institutions in Moldova and with the new Technological Park affiliated to ELIRI. MOLD-NANONET will stimulate the creation of a bridge between applied research and innovative business. Focus is on a new research and training program for young researchers at ELIRI and BELTI in integrated nanostructure networks for implementation in intelligent systems. This will be realized through:- Combining existing facilities at ELIRI in the field of micro-nano-technology with new equipment to extend the expertise to integrated networks of nanostructures based on magnetic, thermoelectric and shape memory metals for applications in intelligent systems based on synergetic integration of nanoelectronics, fine mechanics, product design and soft development.- Establishment of a training program to integrate the principles of nanoscale science in research and coursework for the development of a new generation of experts at the intersection of nanoelectronics, fine mechanics, product design and soft development.- Training modules to teach Master and PhD students how to promote a new technology, novel material or device to the market via technology transfer based on innovation.- Training modules will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'The missing galaxy question at large scales: challenging the paradigm of galaxy formation'.

assistant: **Objectives**

The standard theory of structure formation and evolution via accretion and hierarchical merging of cold dark matter-dominated halos (CDM) is able to explain most of the present observations of the Universe on large scales. However, recent analyses of structure on galactic and subgalactic scales show discrepancies with observations.Using N-body/SPH cosmological simulations this project will address one of the most severe challenges faced by current models of galaxy formation: the missing satellite question. In particular, numerical simulations of CDM predict over an order of magnitude more subhalos around Milky Way-like galaxies than the number of dwarf galaxies observed around the Milky Way.This inconsistency persists in overluminous elliptical galaxies (o r fossil groups) that have masses up to 40% of the nearby galaxy cluster Virgo. Fossil groups are missing ~500 satellites with luminosities that occur at the predicted frequency in the Virgo cluster. Moreover, the 'missing galaxies' in fossil groups are as luminous as the Milky Way with a velocity dispersion ~150 km/s.These mass scales of the missing galaxies are so high that it is much more difficult to invoke gas processes to cause them to disappear. Combining unique data spectroscopy inferred from ESO telescopes for a sample of fossil groups with high-resolution simulations for groups with similar masses will test how pervasive the missing satellite question is on the scale of groups and small clusters.The research project will address the nature of the transition from objects with a weak substructure function like Milky Way or fossil groups to the abundant substructure of galaxy clusters. It will try to answer to the question whether these systems have properties more similar to galactic systems or to mini-cluster
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EUROPEAN APPLICATIONS IN SURGICAL INTERVENTIONS' (EASI).

assistant: **Concept**

EASI uses health care telematics to assist the interdisciplinary tasks of image-guided surgery (IGS), involving professionals from surgery, radiology, and imaging sciences. Established methods for pre-operative surgical planning will be extended to IGS in neuro-and vascular surgery, in which prior three-dimensional viewing of injuries and the surrounding anatomy will underpin a surgical plan for transfer onto patients via registration tools. During surgery, the plan will be tracked and updated in the light of progress and changes in the patient's condition. The project will boost the cost-effectiveness of surgery, while reducing its risks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Regulation of expression and function of integrin alpha6beta1 during leukocyte migration'.

assistant: **Innovation**

Leukocyte migration through blood vessels and directional migration in the extravascular tissue towards sites of infection and/or injury are fundamental components of the organism’s immune response. Their inappropriate occurrence is also an important contributing factor to the development of many inflammatory conditions such as stroke and atherosclerosis. Many details of the associated mechanisms remain unclear in particular the role(s) of leukocyte interactions with extracellular matrix proteins. Of relevance, studies from the host lab have shown that neutrophils upregulate their principal laminin receptor, integrin alpha6beta1 in order to migrate through the vascular basement membrane during extravasation. The aims of my project will be to build on these novel findings through investigations that address the molecular mechanisms involved in alpha6beta1 upregulation and studies into the functional role of this integrin in monocyte migration through venular walls and in interstitial migration of monocytes and neutrophils. These objectives will be studied through the use of in vitro and in vivo models. Specifically, leukocyte expression of alpha6 will be analysed during transmigration in vivo by fluorescence microscopy. The molecular mechanisms leading to alpha6 upregulation will be examined with a series of in vitro experiments and leukocyte migration through the vessel wall and in the interstitium will be explored using intravital microscopy incorporating advanced imaging techniques established in the host laboratory. The obtained results will advance our understanding of the mechanisms that leukocytes employ to migrate towards inflammatory sites and will help to identify potential new targets for development of novel clinical interventions for inflammatory conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Support to the coordination of national research and innovation programmes in areas of activities of the European Energy Research Alliance', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The SUPEERA project supports the implementation of the SET-Plan. Since the SET-Plan does not yet have a mechanism for using cross-cutting research capacities or pooling interdisciplinary activities, SUPEERA will improve the exchange of information between the Implementation Working Groups and make recommendations for joint actions. SUPEERA will also help to accelerate the uptake of new technologies by industry and to examine the impact of EU policies in the view of bringing the SET-Plan forward in the broader context of the Clean Energy Transition.


**Keywords:** SET-Plan, SET-Plan Implementation Plan, Implementation Working Group, EERA, Clean Energy Transition, Accelerating Innovation, Transfer to Industry, Indicators, Policy Translation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'PERmanent MAgnet Network for the European Transition'.

assistant: **Innovation**

PERMANET is a Sustainable REE Innovation and Supply Network covering the full Rare Earth Elements (REE) Permanent Magnet (PM) value chain. It is structured upon 5 layers: 1) Three Sustainable, Connected Tech ‘Hubs’ segmented along the full REE PM value chain and organizing thematic collaborative R&D and supply ecosystems 2) 13 fully Scalable Innovations to reach TRL7 and expand in scale and deployment range along the entire value chain 3) A structural layer of R&D infrastructure, equipment and services to fuel Pilot and Demonstration activities 4) Five Enabling “Engines” addressing the key conditions for sustainable and competitive REE supply 5) All embedded within a single PERMANET Network Infrastructure with its own, sustainable organizational model.The Network accelerates leading-edge innovations, from REE extraction from mining tailings and hydrometallurgical processes to oxide reduction and innovative production processes, all the way to the production of innovative PM and their testing by end users in industrial environment across 1/ E-Mobility 2/ Energy 3/ Industrial Equipment. PERMANET also secures key sources of REE such as leading mining projects from the EU and Partner Countries, as well as End of Life (EoL) sectors (WEEE, EV, etc.). The project relies on enabling activities ranging from strategic venturing to investment support to build sub-optimal EU REE PM Segments. The project unlocks viable reserves of REE including unconventional sources and will demonstrate novel, cost-effective, and environmentally sound REE extraction, processing, and separation routes, as well as demonstrate the first EU hub for PM boosting circular PM technologies to deploy at market scale. The project is ready to be fully integrated with other EU-backed PM Hubs and aims to grow in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Incentives and Dynamics of Innovation'.

assistant: **Concept**

Innovation is the key driver of competitiveness and growth. It supplants existing technologies and erodes the market position of firms. This creative destruction lies at the heart of endogenous growth models. This proposal studies how patent rights shape innovation incentives and the micro-dynamics of technological competition in Europe and the U.S.  Patent rights are a key policy instrument to enhance incentives, and it is critically important that patent-granting agencies function effectively. These incentives influence the dynamics of technological competition, and the extent to which small firms compete effectively with large firms. This proposal exploits patents as a window onto the dynamics of technological competition. Creative destruction operates through innovation and patents reflect the dynamics at this level. Patents are more informative when granting agencies effectively screen to ensure that inventions meet an appropriate patentability standard. Thus, screening is integrally linked to the broader study of innovation competition and creative destruction. This proposal fills critical gaps in the literature, using frontier methodological and empirical tools, and contributes to evidence-based policymaking in science and technology. There are four thematically linked research strands, all of which break new ground. The first strand develops an economic model of screening by the European Patent Office, which incorporates its unique institutional features and enables us to quantify its effectiveness. The second empirically analyses key administrative mechanisms in the European and U.S. patent offices designed to correct screening errors. The third develops a methodology to assess whether the patentability standard is set at the efficient level for society. The fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project '‘Freedom, dignity and justice’: A comprehensive approach to the understanding of youth exclusion and the prospects for youth inclusion and overall change in the South and East Mediterranean'.

assistant: **Objectives**

The 2010-2011 youth-led wave of protests in the South and East Mediterranean, could be described as the coming on the scene of a new generation united by a shared experience of marginalisation and by new ways to protest and act. Important as this phenomenon could be for the future of the SEM, it still escapes the main frames of analysis utilised by academic research. Youth studies in the SEM, while producing important findings and insights, have failed so far to give a multi-dimensional and comprehensive understanding of the economic, political and social disadvantages faced by youth in the region and of the possible evolution of young people’s role in national or regional developments.This project aims at filling this important gap in our knowledge of the SEM by offering a comprehensive multi-level, interdisciplinary and gender-sensitive approach to the understanding of youth in the region. By combining the economic, political and socio-cultural spheres and a macro (policy/institutional), meso (organisational) and micro (individual) level analysis, POWER2YOUTH will explore the root causes and complex dynamics of youth exclusion, while investigating the factors fostering youth inclusion.Building on a conceptualisation of youth that gives prominence to youth as potential agents of change, the project starts out from the assumption that youth exclusion is the result of unequal power relations in society, in as much as effective youth inclusion can only be fostered by a bottom-up process of transformation of the systemic inequalities that lead to exclusion in the first place. From this premise comes the project’s emphasis on the study of the potentially transformative impact of individual and collective youth agency searching for instances of empowerment leading to active
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Engineering Bio-inspired Materials for Biosensing and Regenerative Medicine'.

assistant: **Concept**

In Naturale CG I propose transformative bioengineering approaches that will overcome severe limitations in current materials in two main areas, namely 1) Biosensing and 2) Regenerative Medicine. A key focus is on understanding and engineering the biomaterial interface using innovative designs and state of the art materials characterisation methods. Firstly I aim to transform the way that we can currently detect disease through innovations in the design and development of nanomaterials-based biosensors that could be used to detect a number of diseases with global implications, such as cancer, malaria, heart failure and tuberculosis. These innovations in biosensor design will involve both building on our existing highly successful work on plasmonic biosensors and also involve the design and development of completely new polymersome and fluorescent based biosensors. Another key aim of Naturale CG is to design first in kind biosensors for the facile detection of microRNAs. Secondly, the goal of regenerating failing organs before the body as a whole is ready to surrender, is now timelier than ever and one in which the design of new bio-inspired materials can play an important role. In Naturale CG I will build on my previous research in the design of 3-dimensional tissue engineering scaffolds and address an important new direction in the engineering of new bio-inspired conducting polymers as tissue engineering materials to promote cardiac tissue regeneration. First-in-field biomaterials-based innovations generated from this programme could enable far more effective regeneration of functional myocardial tissue which has been notoriously difficult to achieve thus far. Whilst I will lead this grant and the research within it, the proposed innovations are truly multidisciplinary