RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Technology Advances and Key Enablers for Module Integration for 5 nm'.

assistant: **Objectives**

In line with industry needs, Moore’s law, scaling in ITRS 2013/2015, and ECSEL JU MASP 2016, the main objective of the TAKEMI5 project is to discover, develop and demonstrate lithographic, metrology, process and integration technologies enabling module integration for the 5 nm node. This is planned with available EUV/NA0.33 scanners that are optimized for mix and match with existing DUV/NA1.35 scanners, and with system design and development of a new hyper NA EUV lithography tool to enable more single exposure patterning at 5 nm to create complex integrated circuits. Process steps for modules in Front-end, Middle and Back-end of line are discovered and developed using the most advanced tool capabilities and they are evaluated morphologically and electrically using a relaxed test vehicle. During the development, specific challenges in metrology are assessed and metrology tools are upgraded or newly developed. The results are demonstrated in the imec pilot line with qualified metrology tools at the 5 nm node. The TAKEMI5 project relates to the ECSEL work program topic Process technologies – More Moore. It addresses and targets, as set out in the MASP, at a (disruptive) new Semiconductor Process, Equipment and Materials solutions for advanced CMOS processes that enable the module integration of electronic devices for the 5nm node in high-volume manufacturing and fast prototyping. The project touches the core of the continuation of Moore’s law which has celebrated its 50th anniversary. The cost aware development process supports the involved companies, and places them in an enhanced position for their worldwide competition. Through their worldwide affiliations, the impact of the TAKEMI5 project will be felt outside Europe in America and Asia Pacific semiconductor centers an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'VolThinSens. Challenging societal needs involving ions detection: New strategies for the development of Voltammetry ion Sensors based on Thin membranes'.

assistant: **Innovation**

Modern society is evolving to a scenario in which all daily activities will be monitored using smart sensors. The provision of rapid, reliable and decentralized data is crucial and chemical sensors are current candidates for this purpose. VolThinSens puts forward an innovative sensing strategy from the ground up for reliable detection of ions addressing problems that constitute the bottleneck for the final application of electrochemical sensors in real contexts. To achieve this, the research methodology of VolThinSens involves the exploration of thin ion-sensing membranes based on new materials by using voltammetry and innovative techniques that the project will put forward for the study of the membrane robustness. The developed sensors will be interrogated using coulometry towards a calibration-free technology based on counting charges of the ion analyte that are implied in the electrochemical process. VolThinSens will provide a solution for these two challenges offering robust ion sensors with a wide application perspective within EU priorities such as “citizens’ welfare” and “protecting nature”, among others. The final demonstration of the concept is conceived as the integration of the developed voltammetric sensors for the detection of two ions with pharmacological/clinical and environmental relevance as proof-of-concept: lithium and ammonium. Thus, lithium will be detected in urine, serum and dissolution testing of pharmaceuticals and ammonium in aquatic systems. Interestingly, in situ sensing is aimed through the implementation of the ammonium sensor into a custom-built profiler ion analyser and its deployment in a lake for levels mapping in depth and time axis. VolThinSens will enhance EU excellence and competitiveness in pharmacological/clinical control as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Accelerating Energy renovation solution for Zero Energy buildings and Neighbourhoods'.

assistant: **Concept**

RenoZEB aims to unlock the nZEB renovation market leveraging the gain on property value through a new systemic approach to retrofitting that will include innovative components, processes and decision making methodologies to guide all value-chain actors in the nZEB building renovation process; including integrated solutions with highest impact in the revalorization of the building. This will be achieved through: (a) Development of an innovative holistic, cost-effective and fast deep retrofitting methodology fornZEB. (b)Supporting the methodology for nZEB renovation, through ICT tools. (c) Development of a cost-effective and non-intrusive prefabricated multifunctional modular “plug and  play” system for the renovation of buildings, (d) Increasing the post-retrofitting property value, through the transformation of buildings into an Active Energy. (e)Nodes through a smart control & monitoring system (f) New collaborative multi-value, multi-stakeholder methodologies and decision making process for selecting the best energy efficient renovation strategy. (g) Creation of new drivers of change for the Real Estate Industry creating fresh post-renovated property value schemes. (h) Demonstration to the Market of the Replicability of the Holistic Methodology and New Technologies through. (i) Three Virtual Demonstration sites. (j) Boosting the NZEB market through training and awareness of the value chain. RenoZEB addresses all the relevant aspects from the call, but also many of the issues expressed in the work programme. RenoZEB will provide cost-effective plug&play solutions for  a large scale deep NZEB rehabilitation schemes, ensuring the integrability of all its components, methodologies, training, guidelines, and demonstration cases (real and virtual) that show and ensure the r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nucleosome Structure & Function across Biological Scales and Biological Function' (NUCLEOSOME4D).

assistant: **Innovation**

Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand how nucleosome structure is established, maintained and manipulated. Our Marie Curie Initial Training Network will carry out multidisciplinary, collaborative research projects focused on deciphering nucleosome structure and function in space and time (Nucleosome4D). Our main objective is to provide our young researchers with world-class research & training in nucleosome biology. We will use cutting-edge, interdisciplinary methods and collaborative projects to determine how nucleosomes are remodeled during transcription, when genes are silenced, as cell divide, as stem cells differentiate, during organismal development and in human disease. We utilize state-of-the-art approaches in structural biology, biophysics, cell biology, live-cell imaging, biochemistry, genetics, genomics and bioinformatics. We will implement a comprehensive training plan for scientific and career development using the best local approaches to research & training, by promoting exchanges, using the advise of our industrial partners and three Visiting Scientists, by sharing reagents and expertise, as well as through a structured set of scientific workshops and complementary skills training courses. Together, our effort will ensure the multidisciplinary and intersectorial training of a new cohort of young European researchers. This will allow our trainees to take the opportunities and meet the challenges of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deep-learning for structure-based discovery of adaptive immune receptors' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

B- and T- cell adaptive immune receptor (AIR) repertoires are highly diverse, enabling response to a wide range of pathogens. While sequencing of an individual's immune repertoires is becoming common, our ability to convert these datasets into comprehensive antigen exposure information to inform clinical decisions is limited. The major challenges are to identify the antigens recognized by B-cell and T-cell immune receptors (BCRs/antibodies and TCRs), model their structures and determine their epitopes. Experimental approaches for epitope mapping are costly and low-throughput. While deep learning-based models have revolutionized structural biology by predicting highly accurate structures of proteins and protein complexes, they rely on multiple sequence alignments (MSAs) that are not available for the AIR-antigen interactions. Recently, my group has designed geometric deep learning models for AIR structure modeling and for epitope prediction without MSA. In this project, I will build on my expertise in modeling protein-protein interactions, including AIR-antigen, and in geometric deep learning to develop accurate and high-throughput models that address the specific challenges of AIR-antigen systems. My main goals are to develop deep learning-based models for: (i) accurate and high-throughput end-to-end structure modeling of AIR-antigen interactions; (ii) design of epitope-specific AIRs for targeting broadly neutralizing epitopes and optimized antigenicity profiles; and (iii) structure-based specificity prediction for mining large AIR repertoires.These approaches will advance the analysis of immune repertoires, improve our understanding of immune response, and enable designing vaccines and therapeutics with broad specificity and resistance to antigenic mutations. Moreover,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CENTRAL ITALY INNOVATION RELAY CENTRE' in the context of a Sixth Framework call.

assistant: **Objectives**

CIRCE will provide cost effective services and qualified support to SMEs and research centres of Latium, Abruzzi and Sardinia in the fields of transnational technology transfer, and more in general, in all matters concerning Innovation. In regions where investment in research and innovation is slowly increasing and the industrial framework is characterised mostly by small traditional enterprises not yet completely innovation oriented and with scarce attitude of working transnationally, CIRCE, within the IRC Network and together with other local innovation key players, has the important role of improving and creating a friendly and homogeneous innovation environment by stimulating a better integration between the world of research and industries and by encouraging local companies to work with European ones.To reach these aims CIRCE will guarantee to its clients:a)a bidirectional flow of information linking all available innovation opportunities arisen in Europe with local needs and skills;b)a niche network infrastructure grouping local innovation providers able to support them, with customised assistance, in the different aspects of the innovation procedures;c) the participation in the IRC network actions in order to increase their opportunities in meeting other European entrepreneurs and researchers;d) a qualified level of staff expertise as well as innovative and standardised tools and methodologies to ensure high quality of services and assistance. Through the above services, CIRCE aims at contributing towards the exploitation to the full of knowledge, skill and creativity resources of its regions, thus favouring economic growth and competitiveness of the whole European market.The success of the project will be ensured by an experienced management structure based on a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Manufacturing of a large-scale AM component' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

AM technologies are layer-based and tool-free manufacturing processes, which represent a direct interface between the virtual product development and the real-world production of final products. As fundamental part of the “industrial internet of things” (IIoT), AM is considered to be a flexible solution for a demand-driven supply of individualized products. Especially the LBM technology is considered predestined for industrial production due to its intrinsic characteristic of processing metal additively. Moreover, physical properties similar to the ones of conventionally manufactured parts are achievable. LBM enables the flexible and fast production of near net-shape metal parts with up to 100 % density.MOnACO aims at the design optimization and successful additive manufacturing (AM) of a large-scale (diameter of 1 m) aircraft engine’s component via laser beam melting (LBM) technology. The project contains the development of new design guidelines and tools for the redesign of large-scale LBM structures and the implementation of the complete AM process chain.In accordance to the topic description (JTI-CS2-2018-CfP08-ENG-01-32 ), the approach splits into three main tasks: Component analysis, design and optimization; additive manufacturing optimization and validation; component design experimental investigation.


**Keywords:** Additive Manufacturing AM Laser Beam Melting LBM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Induction of B cell immunity in the lung mucosa' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Vaccination is widely considered one of the greatest medical achievements for preventing infectious diseases. The basis for most currently licensed human vaccines relies on the induction of high affinity antibodies by antigen-specific B cells that can neutralise  pathogens in case of future exposures. The widespread immunity that vaccination conveys has led to worldwide eradication of smallpox and the elimination of diseases such as polio, diphtheria, and tetanus from most parts of the world. In spite of the worldwide effort to generate a universal flu vaccine, the induction of long-lasting protective immunity has been, so far, unsuccessful owing to the rapid antigenic variation of influenza virus. Due to these limitations, influenza infection remains a serious threat to public health and economy, with 5 to 30% of the world population acquiring seasonal influenza virus every year. Interestingly, it was recently shown that antibodies derived from lung-resident germinal centre B cells, unlike those arising from lymph nodes or spleen, bear the ability to neutralise different strain variants of the virus. These findings not only uncover the physiological advantage of tissue-specific germinal centres but also underscore the potential of targeting B cells directly at the lung mucosa to generate protective vaccines against highly variable viruses. My research plan aims to unveil the early events involved in the induction of B cell immunity at the lung mucosa, with a focus on how respiratory antigens are delivered to B cells at the barrier surface. A precise delineation of the initial steps required for the generation of broadly-neutralising antibodies upon respiratory infection will provide invaluable medical insights towards the development of a universal flu vaccine.


**Key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Light-driven Chemical Synthesis using Cytochrome P450s'.

assistant: **Innovation**

The goal of this proposed research initiative is to engineer chloroplasts into production units for high value bio-active natural products. The first aim is to re-route the biosynthetic pathways for these compounds into the chloroplast and to boost compound formation by optimizing and channeling reducing power from photosystem I into to the energy demanding steps. By these measures we aim to overcome the inherent limitations in plants to channel photosynthetic fixed carbon and reducing power directly into production of desired bioactive natural products. Our production targets are diterpenoids with the anti-cancer drug ingenol-3-angelate and the adenylyl cyclase activator forskolin as the two chosen test compounds. Formation of the complicated hydroxylated core structures of these compounds is catalyzed by diterpenoid synthases and cytochrome P450s. These will be identified and expressed in the chloroplast. The ultimate aim is to construct a single supramolecular enzyme complex effectively using solar energy to produce complex diterpenoids. This will be accomplished by tethering the terpenoid synthases and the key P450 enzymes directly to the photosystem I complex using some of the small membrane spanning subunits of photosystem I as membrane anchors. The experimental systems used will initially be transient expression in tobacco and then move to stably transformed moss (Physcomitrella patens). The production system is built on the “share your parts” principle of synthetic biology and the aim is to construct a modular ‘tool box’ as template for tailoring the synthesis of a whole range of valuable bioactive diterpenoids. Typically, these are difficult to obtain because they are produced in very low amounts in plants difficult to cultivate. The proposal opens up entirely
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Distributed storage based on sparse-graph codes' under Horizon 2020.

assistant: **Concept**

The recent years have witnessed the explosion of services and applications such as email, cloud computing, socialand media networks, and video sharing. The grand challenge is to store, process and transfer this massive amountof data. According to recent estimates, the data to be stored grows at a rate of 45% per year, a factor of 40 by2024. Data centers typically employ a collection of cheap devices/nodes, which are connected forming a so-calleddistributed storage (DS) system, where a central server keeps track of where each file is stored and performs allnetwork operations. Every day, knowingly or unknowingly people connect to various private and public DS systems.It is nowadays accepted that current DS systems cannot face the unabated growing of digital data volume. Nextgenerationstorage systems desperately need new technologies to improve their robustness to node failures, storageefficiency, complexity, and cost efficiency, in order to sustain the information revolution of modern societies.This project addresses the challenges above using modern coding theory and optimization theory. Our focus ison the application of sparse-graph erasure correcting codes to large DS networks. The proposed project falls into thecategory of fundamental research, but it is driven by practical concerns, and we expect our findings to give new andrelevant insights for the design of practical coding schemes for next-generation DS systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantum Metrology with Trapped Ions', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We propose a quantum algorithmic approach to metrology and its implementation using trapped-ion qubits. Active decoherence suppression methods such as decoherence-free subspaces, Quantum error-correction codes and dynamic decoupling will be used to reduce the effect of noise while amplifying a measured signal, thus improving on the measurement signal-to-noise ratio. An ion trap architecture that best suits this approach will be designed and realized. Several metrology protocols will be demonstrated. Finally, we propose to apply these methods in actual precision measurements, including the detection of magnetic interaction between ions at large distances, optical frequency metrology, the measurement of parity violation in atomic transitions, and the detection of correlations in an ultra-cold gas of neutral atoms. The implications of scaling-up to large numbers of probe-qubits will be investigated as well.