RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PrEseRvIng and sustainably governing Cultural heritage and Landscapes in European coastal and maritime regionS'.

assistant: **Innovation**

PERICLES promotes sustainable governance of cultural heritage (CH) in European coastal and maritime regions through the development of a theoretically grounded, multi-actor participatory framework. To meet this challenge, PERICLES has formed a strong interdisciplinary consortium comprised of research institutions, regional government and heritage partners representing 15 different disciplines.PERICLES addresses the following objectives: a) develop an in-depth, situated understanding of the CH of marine and coastal land/seascapes, including knowledge across local, spatial, environmental, social and economic aspects; b), develop practical tools, based on stakeholder involvement and participatory governance, for mapping, assessing and mitigating risks to CH and to enhance sustainable growth and increase employment by harnessing CH assets; c), provide policy advice to improve integration of CH in key marine and environmental policies and the implementation of associated EU directives; and d), develop effective knowledge exchange networks.To fulfill these objectives PERICLES uses a scientific approach guided by the theories of: a) space, place, and identity; b) resilience and adaptation; and c) deliberative and participatory governance. We will apply a range of participatory, deliberative and action research methods from the social sciences and arts directly involving decision-makers, stakeholders and the public.   PERICLES meets the needs of the work program by: contributing to European efforts to promote evidence-based research on the impact of participatory approaches in CH policies and governance; using a multi- and transdisciplinary approach; addressing in/tangible CH in a geographically balanced way; involving and developing CH networks of local stakeholders and policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The service for modular MAGnetic microSYStems design and packaging support' (MAGSYS) under Fifth Framework.

assistant: **Objectives**

MAGSYS is a European service, which aim is to improve the access to magnetic MR-based microsystems. The MAGSYS service is based on a modular design principle, ensuring custom prototyping and product development, at low cost and risk and short time to market cycles. MAGSYS will be a follow-up of MAGFAB. MAGFAB offered Multi-Project-Wafer (MPW) customer runs in the field of magnetic sensor based microsystems. In most cases, these MPW runs initiated basic customer research for prototyping future devices and study their performance. The final steps from bare dice design and fabrication, which was the provided service of MAGFAB, to high performance microsystems solutions, need additional support activities, such as packaging and magnetic components design.Work description:The project workplan has been set up in 9 different work packages:WP1: Description of services;WP2: Dissemination and marketing;WP3: Consultancy and systems design guidance/Packaging service development;WP4: Simulation of magnetic microsensors by numerical structure analysis;WP5: Modular systems design and manufacturing;WP6: Proactive customer acquisition;WP7: Co-ordination, cluster operations;WP8: Management and performance criteria monitoring;WP9: Exploitation and technology implementation plan. Following this plan, the project will start with a description of the services offered by the MAGSYS consortium (WP1).The next work package deals with the dissemination and marketing strategies, that will be defined by all partners. The design, simulation and manufacturing of MR-based microsystems will be addressed in WP3, WP4 and WP5, respectively. Throughout the project, internal as well as customer workshops will promote a proactive customer acquisition (WP6).The co-ordination and management of the project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Photosynthesis and photoprotection regulation in marine cyanobacteria and its potential applications' (PHOTO-CY-APPs).

assistant: **Innovation**

Carotenoids evolved in cyanobacteria as components of membranes providing a structural role and likely influencing permeability to oxygen. Then they became complexed with proteins that enabled a great diversification in their functions to include both 1O2 quenching and light harvesting in photoprotection. Photo-cy-apps is an ambitious project with the purpose of gaining a comprehensive understanding of the role of OCP and the new HCPs and CTDHs on photoprotection in marine cyanobacteria, with their potential application. The ecological importance of these microorganisms reinforces the relevance of this project, since the putative protecting role of OCP in a major subset of marine picocyanobacteria could be a key factor for their abundance, particularly in regions close to the surface of the ocean, subjected to high irradiances. This project brings two research laboratories together with different and complementary expertise, the Kerfeld lab at the Plant Research Laboratory (PRL) at Michigan State University (MSU and LBNL) in the USA with the expertise in bioinformatics, biophysics and structural biology, and the Garcia-Fernandez lab at the University of Cordoba (UCO) in Spain with the expertise in physiological studies in marine cyanobacteria, to determine the role of these car-binding proteins in marine photoprotection and provide the foundation for the Fellow for her independent career after this interdisciplinary training-through research.


**Keywords:** marine cyanobacteria, carotenoids, photoprotection, Orange Carotenoid Protein, Helical Carotenoid Protein, Phycobilisome, Optogenetics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Imagining the future in post-industrial Taranto, Italy' (TarasLAB) under Horizon Europe.

assistant: **Objectives**

The port city of Taranto has grown in the shadow of ILVA, the largest steel plant in Europe. Since the 1960s, ILVA has provided the people of Taranto with livelihoods and hopes for prosperous futures but also contributed to the city’s environmental degradation and public health crisis. In 2012, ILVA was seized after a court's preliminary hearing deemed the steel plant responsible for Taranto's public health and environmental crisis. To reduce polluting emissions, the blast furnaces were shut down and the steel workforce faced layoffs. A socio-economic crisis ensued, adding to the environmental and public health crisis. Since then, the future of Taranto has been on hold: the state's promises to implement environmental policies and nationalise the plant have never materialised. Exploring the tensions between labour and environment, TarasLAB asks: How can the future be imagined and reclaimed when people's livelihoods mostly depend on what is likely to threaten their lives? To answer this question, it combines ethnographic and collaborative visual methods to engage the research participants in a collective project of multimodal storytelling, which will unfold through and culminate in the co-production of an ethnographically informed graphic novel.TarasLAB leverages anthropological theories and methods to analyse timely issues of interests to both society and policymakers: in addressing Tarantini’s concerns about their future, the project aligns its objectives with the European challenges to make Europe sustainable and secure by 2050. The project's results will add to scholarly debates on sustainable futures in the European semi-periphery while offering a unique contribution on the epistemological affordances of Graphic Anthropology. The Department of Social and Cultural Ant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Astrophysical constraints on the identity of the dark matter', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The identity of the dark matter is a fundamental problem in Physics whose solution will have major implications for cosmology, astronomy and particle physics. There is compelling evidence that the dark matter consists of elementary particles created shortly after the Big Bang, but searches for them in the laboratory and from astrophysical sources have proved inconclusive. The currently favoured candidate is cold dark matter or CDM. This forms the basis of the standard model of cosmology, LCDM, whose predictions, dating back to the 1980s, turned out to agree remarkably well with observations covering a staggering range of epochs and scales, from the temperature structure of the cosmic microwave background radiation to the large-scale pattern of galaxy clustering. Yet, this agreement is not exclusive to CDM: models based on other types of particles -- warm, self-interacting or asymmetric, for example -- agree equally well with these data but differ on scales smaller than individual bright galaxies. These are the scales targeted in this application in which we propose a comprehensive investigation of small-scale structure, with the aim of testing dark matter candidates, by focusing on three key astrophysical diagnostics: strong gravitational lensing, dwarf galaxies and stellar halos. We propose a joint theoretical and observational programme exploiting three major developments: SWIFT, a new code developed at Durham that will enable cosmological hydrodynamics simulations an order of magnitude larger than is possible today; SuperBIT, an innovative balloon-borne wide-field imaging telescope that will collect gravitational lensing data for hundreds of galaxy clusters; and DESI, a spectro-photometric survey that will acquire 10 times more spectra of stars in the Milky Way than
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Thrombotic MEMOry-Linking a break in tolerance to platelets to REthrombosis'.

assistant: **Objectives**

Thrombotic diseases like venous thromboembolism (VTE) are leading causes of mortality worldwide, due to their unpredictable, relapsing occurrence. The strongest predictor of a thrombotic event is a previous thrombosis, implicating that VTE has systemic memory effects beyond local clot formation triggering thrombotic relapse. In T-MEMORE, I will go beyond the state-of-the art of thrombosis research by testing the ground-breaking concept that VTE is not only a local event, but a chronic, systemic disease caused by an immune response to platelets mimicking a break in tolerance.My recent research revealed that venous thrombosis is the outcome of a sterile inflammation primarily directed against one target: activated platelets. I found that platelet-directed immunity in turn fosters platelet activation and thrombotic vessel occlusion. The systemic and long-term thrombotic memory effects of platelet-directed immunity are unknown, but have important implications for unmet clinical needs: (1) identification of patients at risk of rethrombosis; (2) personalisation of the duration and type of secondary prevention; (3) discovery of new approaches for VTE prophylaxis beyond anticoagulants with their inherent bleeding risk.The thrombotic memory effect caused by a local thrombosis will be deciphered by innovative functional in vivo imaging in the bone marrow  as the site of platelet production  as well as spleen and liver  as sites of platelet removal (objective 1). The potential of manipulating platelet-directed immunity to prevent thrombotic relapse will be tested in a clinically relevant model of rethrombosis (objective 2). In a translational approach, I aim to uncover a platelet-directed immune profile in patients with recurrent VTE, which would be a key step towards a personaliz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mediterranean desertification and land use. Project 4 ephemeral channels and rivers' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

To improve the understanding of the impact of desertification on headwater channels and rivers, where desertification is understood to include the effects of both human activities and climatic changes, and to extend these findings to the development of advice to those responsible for managing the environment and environmental change in Europe.Investigation of the controls on gully development and expansion will allow modelling of these effects using computer simulation to predict the impact through space and time of climatic and socio-economic factors of runoff and sediment yields from headwater channels. Changes in ephemeral rivers in dry Mediterranean environments will be studied to develop a model to predict changes in channel morphology, sediment and water yield and surface cover use potential of the channels. The model can then be used as a management tool for ephemeral channels. Project 4 also includes a coordination service for the whole MEDALUS III programme. Coordination includes running plenary sessions and group meetings, and preparing publications of working papers and reports of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integration of the Latvian state of wood chemistry in the European research area' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The main aim of the activities of the Latvian State Institute of Wood Chemistry is to meet the social and economic demands of Latvia by developing innovative products and technologies on the basis of wood and other types of biomass carrying out multidisciplinary theoretical and applied studies. The aim of the project is to integrate this Institute into the European research by establishing close cooperation with the leading European institutes: exchanging information and ideas; creating an approach to unique research equipment and methods, promoting the renewal of the Institute's scientific staff, involving young researchers in the science turnover. This project will intensify the scientific studies and, in collaboration with the Supervisory Board, will actualise the research directions. As a result, the development of Sees in Latvia and in general will be promoted for rational. Environmentally friendly utilization of wood and biomass.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of selective antagonists and subtype selective ligands for the D-myo-inositol 1,4,5-trisphosphate receptors.""' in the context of a Seventh Framework call.

assistant: **Objectives**

The overall aim of this project is the development of novel ligands to probe the role of D-myo-inositol 1,4,5-trisphosphate receptors (InsP3Rs) in intracellular calcium signalling. Two key goals are the development of selective and potent non-inositol InsP3R antagonists and the development of ligands that bind selectively to one of the three subtype of InsP3Rs. Using hits from an in silico screen, we will develop and then employ thermal shift analysis, surface plasmon resonance and isothermal titration calorimetry assays to identify promising lead compounds. We will determine whether these compounds act as agonists or antagonists using a fluorescence-based sea urchin egg homogenate assay before data are obtained in further, more intact, cellular assays. In order to facilitate the use of these compounds in cells they will be rendered cell permeant using previously developed technology. X-ray crystallographic studies with these compounds, in particular the antagonists, will be undertaken in order to shed light the molecular mechanism of InsP3R activation. Subtype selective ligands will be useful in determining the particular role of each of the InsP3R subtypes in normal cellular function and cellular dysfunction, which underlies diseases such as heart arrhythmia and cardiac hypertrophy. This project has been designed to capitalise on the skills of the fellow in chemical synthesis and her knowledge of phosphate bioisosteres. Further advanced training will be provided in chemical synthesis, biophysical techniques and molecular biology in addition to cooperation with industrial collaborators Inhibox. Consequently, the fellow will significantly enhance and diversify her skills in this highly multidisciplinary project.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Artificial Intelligence and Big Data CSA for Process Industry Users, Business Development and Exploitation' (AI-CUBE).

assistant: **Concept**

AI-CUBE seeks to enhance the understanding of different digital technologies related to artificial intelligence (AI) and big data (BD) applied in process industries for all the SPIRE industrial sectors. At the start of the project in September 2020 there were eight SPIRE industrial sectors considered, namely: cement, ceramics, chemicals, engineering, minerals and ores, non-ferrous metals, steel and water. At the start of 2021, also pulp & paper and refineries were added – which were then considered and integrated into the list of sectors being analysed through the project. Therefore, a close collaboration with industry is mandatory to achieve in-depth insights into possible application areas of AI for processes, technology, sensor applicability and assessment of their level of penetration.The overall project approach is based on the development of a 3-dimensional conceptual matrix based on:1)AI and BD technologies2)Application areas (activities and industrial processes)3)SPIRE sectorsAI-CUBE’s main goal is to define a roadmap in AI and the use of BD for the process industry and their maturity level across the industrial sectors, including guidelines for implementation. Industrial stakeholders and associations will validate the consolidated roadmap ensuring solution feasibility and benefits for the European industrial community. A crosslinked vision over process industry sectors shall facilitate cooperation and boost technologies deployment at their full potential. An in-depth consultation with industry (association, representatives, companies) will provide an overview of current AI and BD algorithms application, identifying exploitable synergies among sectors. A deep study of the application areas in planning and operations within other industrial sectors facilitates a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Harnessing Specialized Metabolism from Anaerobes'.

assistant: **Innovation**

Anaerobic bacteria, a group of microorganisms that thrive in the absence of oxygen, have a significant impact on the quality of life on Earth. They play a crucial role in biotechnology and are essential components of the gut microbiota. As such, they are of tremendous importance for human, animal, and environmental health. On the other hand, certain anaerobes can be life-threatening pathogens. In light of this, there is an urgent need for a deeper understanding of the specialized metabolites of anaerobes, which could function as chemical mediators, virulence factors, and antibiotics. Although genome analyses indicate that anaerobic bacteria hold an enormous potential for producing structurally unique compounds, biosynthetic gene clusters are typically downregulated or silent under laboratory conditions. Synthetic biology approaches to unearth these cryptic pathways have been hampered by the lack of universal activation strategies, the cumbersome genetic tractability of anaerobes, and the incompatibility of standard expression systems with the oxygen-sensitive biosynthetic enzymes.The AnoxyGen project seeks to unearth the vast structural wealth of natural products from the anaerobic world and leverage their unique biosynthetic machinery using a highly versatile anaerobic expression platform. This ambitious initiative comprises four work packages aimed at refining synthetic biology tools, creating gain-of-function anaerobes, discovering novel drug candidates and virulence factors, and engineering biosynthetic pathways to create metabolic diversity.By achieving these objectives, AnoxyGen will grant a comprehensive overview on specialized metabolites and biocatalysts of anaerobes, which have great translational value for medicine, ecology, and biotechnology. In addition to