RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Crosstalk between nuclear envelope and DNA Damage Response: Role of nucleoporin TPR in the maintenance of genomic integrity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Each cell in the human body receives thousands of DNA lesions per day. To counteract threats posed by DNA damage, cells have evolved an integrated signaling network called the DNA-damage response (DDR). This mechanism allows cells to detect DNA lesions, signal their presence and promote their repair. Mutation of DDR genes, which serves as a biological barrier against tumor progression, leads to cancer development2. A large-scale proteomic analysis of proteins phosphorylated in response to DNA damage by checkpoint kinases ATM and ATR identified extensive protein networks responsive to DNA damage. Interestingly, among the proteins identified to be phosphorylated upon DNA damage were several nuclear pore complex factors including nucleoporin Translocated Promoter Region (TPR)5. TPR was previously linked to cancer since its N-terminal domain has been found fused with the protein kinase domains of various proto-oncogenes such as RAF and MET resulting in human solid tumors. TPR expression level was found deregulated in many types of human tumors such as breast and liver cancer8. Amplification of TPR was also significantly associated with a shorter survival of patients with pediatric intracranial ependymomas9. All these findings support a critical role for TPR in the mechanism of oncogenesis. By employing state-of-the-art proteomics (SILAC), genetics (in vitro mutagenesis), genomics (DNA binding profiling) and imaging (electron microscopy) technologies we will investigate how TPR prevents tumor genesis via its role in the DDR network coordinating DNA repair, DNA replication and chromatin condensation with the nuclear envelope upon DNA damage. Providing mechanistic insight into the role of TPR in DDR and the maintenance of genome stability will not only contribute to our unders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Interactions between vision and audition in human motion perception' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Human sensory perception is multisensory in nature, as the existence of multisensory neurons shows. Perceptual research in vision and audition is usually done separately. This project will study audiovisual interactions with the aim of understanding perception as an integrated sensory process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'AUTHENT-NET – Food Authenticity Research Network'.

assistant: **Innovation**

It is acknowledged that historically anti-food fraud capability within Europe has not been consolidated and lacks the coordination and support structures available to those working in food safety.  There are various initiatives underway to redress this balance e.g. DGSanté’s Food Fraud network, DG Research’s FoodIntegrity project, as well as numerous national programmes and industry initiatives.  One pivotal area that still needs to be addressed is bringing together national research funding bodies to facilitate the development of transnational research programmes. AUTHENT-NET will address this need by mobilising and coordinating relevant research budget holders in order to facilitate the eventual development of a transnational European funding vehicle that will allow Members States (MS) to jointly fund anti-fraud research.   Authent-Net comprises a core group of 19 participants from 10 MS, 1 NGO and the US, who are either National research funding bodies; experts in food authenticity, and/or experts in transnational funding mechanisms. AUTHENT-NET will:1) Bring together relevant MS R&D budget holders to coordinate inter-disciplinary research effort and build a cohesive and sustainable network2) Undertake stocktaking of existing national research and assess against the international landscape3) Establish transnational mechanisms and instruments for collating and exchanging information  on food authenticity research4) Develop a high level research and innovation strategy for transnational research and a rationale for a potential ERANET on food authenticityThe two year project will have the following expected impacts: improved coordination and communication between relevant MS research budget holders; enhanced cognisance of existing national research; joint strategy for f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Beyond state of the art Efficiency by improving Balance of Plant components', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The BeBoP project will achieve an overall increase in system efficiency and durability and a reduction in Total Cost of Ownership (TCO) of fuel cell systems for heavy duty applications by providing for and incorporating improvements in key balance of plant (BoP) components -  air compression and humidification, and DC-DC conversion. Novel and integrated cell monitoring combined with advanced modelling will lead to overall architectural- and operational optimizations. The project brings together key component developers already actively supplying BoP components into the market (Garrett, Freudenberg and Silver Atena), with the specialist powertrain division of a heavy-duty truck manufacturer IVECO (FPT), alongside two leading European research institutes (SINTEF and DLR) with a strong records in the area of fuel cell systems development and modelling. Novel key BoP components (air compressor, humidifier and DC/DC converter) will be developed from the current status of TRL 3 to TRL 5. The prototype components will be tested to prove performance, either on a fuel cell engine (for the air compressor and DC/DC converter), or at a test bench (humidifier), and iteratively modelled and improved with real time data. Collectively, the developments will bring about a significant optimization of both BoP and system level characteristics, addressing performance, durability and cost targets. Beyond this, next generation fuel cell systems and their scalability will be explored through modelling, involving improved compressor configurations and stack operation on enriched air to further increase system efficiency and validate the applicability to other heavy-duty segments of transport.Through collaboration with its Advisory board, which comprises University of Groningen, Ballard, EKPO,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Health Investments in Central and Eastern Europe' to be submitted under Horizon Europe.

assistant: **Abstract**

To address the low start-up survival rate and the lack of funding in “modest” and “moderate” innovation ecosystems within Europe – namely in Central and Eastern European countries - the consortium (led by EIT Health in collaboration with InnoStars, Civitta and other entities, as well as an advisory board including the EIF) will use their individual expertise to implement activities that build critical mass on both the investor and venture-building front.Given the investment challenges in early-stage ventures, the Project will seek to collaborate with local start-up support organizations to provide capacity building initiatives as well as to derisk local innovators to set the foundations for modest and moderate regions to become sustainable and competitive with more dynamic regions within the European ecosystem.The project will be structured around the impact pathway methodology (scoping, engaging and implementing). The specific objectives are: 1) to build robust and sustainable early-stage investment ecosystems and increase critical mass; 2) to increase venture investments through a) cultivating life sciences local investment and b) attracting foreign investors into the local innovation ecosystem; 3) to provide de-risking and investment readiness support for Dealflow exchange to increase syndication, and 4) to disseminate and implement project outcomes, create European foundation to address fragmentation in EU market and support cross-border investmentsIn addition to said objectives, as well as the expected outcomes set out in the call, the Project will aim to impact wider European goals, including furthering the European Innovation Agenda, increasing investment competitiveness, start-up as wells as job creation, knowledge transfer, and widening European outreach. Furth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Precision tests of the Standard Model using Beauty to Charm decays' (Beauty2Charm).

assistant: **Innovation**

The present matter-antimatter asymmetry of the universe cannot be explained by the Standard Model (SM) of particle physics. I propose to look for the presence of new physics beyond the SM in Charge-Parity (CP) asymmetries using beauty mesons decaying to charmed mesons (Beauty2Charm). A unique feature of these decays is that the SM contribution can be precisely measured using relations between ten decay modes all of which can be measured with in a coherent manner at a single experiment: LHCb at the Large Hadron Collier (LHC). The proposal will make measurements of ten branching ratios and eight analyses sensitive to CP violation using data collected by LHCb in order to test these relations. CP asymmetries larger than a few percent would be an unambiguous signal of the presence of new physics. In order to make these measurements at the required level of precision, I will lead a major upgrade to the way that the LHCb experiment selects proton proton collisions and for which I have laid the conceptual foundations. Real-Time Analysis  will enable a dramatic increase in the the efficiency and signal yield of the decay modes relevant to this proposal, and reduce systematic uncertainties. To test and commission this upgrade I will lead the first ever measurements of beauty hadron production using final states without leptons. The experience gained in the commissioning phase will result in increased efficiencies for the CP sensitive channels leading to the world's most precise measurements and world-leading sensitivity to new physics.


**Keywords:** Flavour Physics, LHC, CP violation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional analysis of introns and gene regulatory sequences aimed at targeted modulation of gene expression' (FINGER) under Fifth Framework.

assistant: **Objectives**

Regulation of gene expression is a complex phenomenon poorly understood. Our project aims to improve our knowledge about non-coding sequences, increasingly show to be relevant for modulating gene expression, using dystrophin gene and dystrophinopathies as model. Among the series of characterised patients, available in the collaborative units, several have unusual mutations and phenotype suggesting a role of non-coding regions. We will analyse these patients in order to identify and functionally study the regulatory sequences responsible. We will define the intronic breakpoints as well as other non-coding regions involved in dystrophin mutations. We will characterise these sequences by experimental studies to test their regulatory function with particular attention to those involved in pre-mRNA splicing. we will evaluate the feasibility of a targeted modulation of dystrophin gene expression using antisense oligonucleotides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The first wireless wind turbine blade sensor for automatic, real-time condition-based monitoring' (EOLOGIX) targeting Horizon 2020.

assistant: **Abstract**

Maintenance costs are one of the largest problems in the wind energy market, adding to up to 40% of total wind turbine costs. Blades take the lion’s share of this, with 20-30% of all maintenance costs. Our solution, eolACC is the first condition-based monitoring on-blade sensor system to combine 3 features: blade crack detection, pitch angle measurements and blade icing detection. Monitoring all these features will save wind turbine owners up to €2.9 M across the turbine lifetime, recovering the investment in eolACC in the first 2 months.We studied the target market and competitors. Forecasts predict the wind power O&M market will grow to €22 bn by 2025. eolACC has full Freedom to Operate in our target markets of Europe, North America and Asia. We currently have over 50 customers which have purchased over 200 of our ice detection sensor system, many of which have been asking for an all-in-one solution as eolACC. We will leverage our connection with them to first expand into France, Belgium and the DACH region in 2021, then the rest of Europe and North America in 2022 and Asia in 2023. Our strategy will be to sell our product first to turbine owners directly, and then through large OEMs. We already have registered interest from several of our current customers (Enercon, e.on. Tecnocentre eolien, EVN, Verbund) to implement eolACC into their systems. We will use our current clients, our connection with Phoenix Contact and local sales partners to assist our dissemination efforts. We require a 24-month project with a budget of €1.62 M to bring eolACC to market. Our Work Plan is composed of 3 Technical Work Packages, one Commercial and one for Project Management. Our Phase 2 project will also result in the creation of 6 new jobs. The project is highly profitable, bringing a 4
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SMAV: Best for the Environment Soda Fountain Smart Valves', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The world is facing a strong challenge due to the great environmental cost deriving from the production and distribution of soft drinks in aluminium cans and plastic bottles. A huge amount of resources is in fact required for  producing, disposing of and especially transporting these products, which consist of more than 80% water.  The above mentioned cost could be reduced improving the quantity of soft drinks dispensed from the tap (so-called ""fountains"") in restaurants, bars and fast food restaurants. A relatively limited amount of soft drinks is presently consumed on-tap because the dispensing equipment is costly to operate.SMAV project will introduce a revolutionary innovation in the fluid management systems currently used in soft drink dispensing ""fountains"". It will develop a new volumetric valve which takes advantage of the properties of shape memory alloys (SMA) and uses new ICT technologies. SMAV solution will replace the solenoid-based valves that are commonly used and which are responsible of many inefficiencies and of the high cost of maintenance of dispensing fountains. At present, soft drink dispensers which cannot ensure a minimum quantity of litres sold every day are not economically sustainable by many businesses. On the contrary dispensing fountains, equipped with our new valve, will operate much better and will cost almost 75% less to maintain than current equipment, so that the minimum number of litres that must be dispensed to ensure economic sustainability will be much lower. As a result, many bars and restaurants will be able to install the new equipment, which simply mix water and syrup on site, producing, in addition to economic benefit to the all players of the sector, many potential environmental advantages every year, as the elimination o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'THE DEVELOPMENT OF SPECTROSCOPIC TECHNIQUES AS ADVANCED SENSORS FOR THE OPTIMISATION AND CONTROL OF FOOD AND PAPER PROCESSING' in the context of a Fourth Framework call.

assistant: **Objectives**

This project will seek to address the requirement of the European food and paper industries for robust and reliable sensors based on spectroscopic techniques.In recent years there has been an increasing interest in the use of infrared and Raman spectroscopies for the analysis of foods and other materials of a biological origin. Substantial development work has taken place within Europe on the development and application of these methods. This work some of which has been coordinated with EU funding (eg FLAIR Concerted Action Nol QUEST"), has highlighted key areas of application and clearly demonstrated the enormous potential that exists. It has been shown, for example, that multi-component quantitative analysis can beperformed on a wide range of samples, that qualitative data can be obtained allowing improved quality control and assisting product development and that the methods offer rapid and sensitive detection of adulteration.However, the major technical hurdles to be addressed relate to the unsuitability of current analytical instumentation for deployment in industrial environments. The maximum benefit of this new technology will be realised when near- and on-line versions of the instruments are produced. This proposal involves partners with the diverse expert skills required to solve the existing technical problems in order to produce equipment suitable for use in industrial settings.The project will consist of three distinct phases:Phase 1 will involve an-depth study of the samples chosen for analysis by partners representing end-users in the food industries. For each product the optimum sample presentation method will be identified and suitable calibration models developed. This work will identify the optimum spectroscopic method and will define the type of instr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Food Fraud Community of Practice: From Outset to Operation' (EFF-CoP), addressing dissemination and exploitation.

assistant: **Impact**

Our aim is to revolutionise the combat against food fraud and enhance transparency in our food supply chains. How? By establishing and mobilising The European Food Fraud Community of Practice (EFF-CoP), a sustainable Research and Innovation eco-system of food fraud researchers and end-users based on solid sociological principles. We have gathered a diverse group of stakeholders in our consortium, scientists, regulators, large and small-sized industry, the organic sector, existing networks with >4200 members, and more to lay the groundwork. They are catalysers to reach out rapidly to a large number of prospective EFF-CoP members. That is only the beginning. We will set out to understand the needs of the various stakeholder groups and the network structure to prioritise content and enhance information flows, and we set up the EFF-Hub as our virtual headquarters, an interactive collaborative space. From there, series of activities will be rolled out – sharing existing research and innovation resources and educational materials, developing new ones – Good Practice Recommendations, factsheets, and case study materials, and we will host engaging virtual and live events to facilitate interactive collaboration. These events involve food fraud festivals, gamification-based training courses, living labs, ‘authentic appetites’ podcast series, the EFF-CoP on Tour program, webinars, virtual cafes, a food fraud incident preparedness workshop, and dedicated events for the future generation. Our goal is to cultivate a vibrant community of over 5000 members at the end of the project, all dedicated to combating food fraud and learning from each other. To ensure our EFF-CoP stands the test of time, we are not only implementing the proven concept of ‘CoP design for evolution’ but also a co