RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Past hurricane activity reconstructed using cave deposits: Have humans increased storm risk?'.

assistant: **Concept**

The proposed research would utilise various geochemical proxies (oxygen, carbon, and trace elements) in cave calcite deposits (stalagmites) to develop extraordinarily high-resolution North Atlantic hurricane activity records for the past five hundred years, extending existing historical datasets by hundreds of years. This new stalagmite record would be the first high resolution record to extend beyond 1850, thus permit more statistically robust comparisons of hurricane activity between pre- and post-anthropogenic greenhouse gas climatic states, and help to constrain any natural cyclicities inherent in North Atlantic hurricane activity. Additionally, the three study sites were chosen to test the hypothesis that variations in the North Atlantic Oscillation (NAO) index may influence hurricane track direction. The records will also be used to reconstruct El Nino-Southern Oscillation variability back through time, something that on its own would be an important result. The research would help evaluate the risk of stronger/more frequent future hurricanes associated with global climate change by allowing more rigorous testing of currently conflicting climate models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Breast cancer stem-like cells specific vulnerabilities: focus in HER2 over-expression and protein glycosylation' under Horizon 2020.

assistant: **Concept**

Breast cancer is the most common cause of female cancer death in Europe, hence it is urgent finding alternative treatments. A small population of cells that display stem cell characteristics has been described in breast cancer (BCSC) and linked to tumour progression, resistance to treatment and metastasis. New therapeutic approaches propose the use of stem cell targeting agents in combination with traditional chemotherapy. However, selective targeting of BCSC is still challenging as they are very similar to normal stem cells. Here, I propose to probe two characteristics that may be specific of BCSC: HER2 over-expression and altered protein glycosylation. I will use state-of-the-art technologies including the standardization of a new protocol to isolate Circulating Tumour Cells (CTCs) from blood, and the generation of a library of CRISPRs targeting all the genes related with protein glycosylation. After six years of postdoctoral stage in New York, I have wide experience in RNAi screens valuable for the library development. Supervised by Prof. Elliott at Newcastle University, I aim to learn the insights of protein glycosylation in cancer. The identification of BCSC specific vulnerabilities has important clinical implications as they represent outstanding candidates for new targeted therapies. Importantly, HER2 and protein glycosylation are mainly located in the surface of the cells, being accessible to targeting agents. The accomplishment of the proposal will contribute to my development as an independent researcher since I will: 1) gain knowledge in BCSC and protein glycosylation, fields with multiple functional implications; 2) generate data to use in my future projects, including a list of targeted therapies candidates; 3) standardize a method for isolating CTCs to fur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Construction of nanoscale molecular presses displaying electrochemically and photochemically induced contrary linear motion of two plates' (NANO-PRESSES) targeting Sixth Framework.

assistant: **Abstract**

The fabrication of molecular machines that display motion of one component with respect to another is currently attracting much interest. Most examples only display motion rather than utilise it to fulfil a particular task. The objective of this proposal is to advance current achievements by fabricating molecular machines whose motion can be exploited to perform a specific function.This will achieved by the construction of self-assembled nanoscale molecular presses consisting of a track along which two functional plates move to open or closed positions upon external (electrochemical or photo-induced) stimulus. The motion of the plates will ultimately be used to activate specific processes, such as an uptake and release system, as well as mimics of chaperones in protein folding and light harvesting systems for photo-induced processes.The construction of these devices utilises a range of techniques including synthetic organic chemistry, coordination chemistry and electrochemical or spectroscopic techniques.  The nature of the methodology is multidisciplinary, leading to the transfer of knowledge and expertise between groups and the formation or reinforcement of European collaborations.The diverse nature of techniques required will give the researcher valuable new skills to complement those he already possesses, which can be applied constructively to the project, leading to a strong base for professional development. The mobility will allow a young researcher to work in a centre of excellence, where both scientific and complementary skills such as research management and communication will be reinforced.The project is highly relevant to the expanding area of nanotechnology and can make a contribution to the public understanding of the subject as well as significant technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dynamic Networks for Lexical Access: Design, Navigation and Interface' (DynNetLAc).

assistant: **Innovation**

.Lexical insertion is a very important process in the production of language, whether verbal or written. It is often metaphorically stated that words are stored in a mental dictionary, called lexicon. The general belief is that the more entries in the lexicon, the better. But having a large number of stored data is not useful if we do not have the right tools to access the information we need. We know also from experience that the lexical choice is not always easy, and sometimes we fail to reach that precise word to express a certain idea, even though we know it exists. Psycholinguists call this fact the tip-of-the-tongue phenomenon or, more technically, dysnomia or anomia.Access to data from the lexicon depends on two factors: a) how words are organized, and b) which mechanisms exist to access the data.Complex Network theory (Newman, 2003) can help to both tasks: organization and navigation of the lexicon. Words can be organized by means of two-layer networks with a double dimension: syntagmatic and paradigmatic. Methods taken from DNA regulatory networks can help to design efficient and affordable navigation mechanisms capable to change the configuration while walked, in order to adjust to the necessities of the user.Therefore, this proposal aims using mildly bio-inspired dynamic complex networks to develop a computational implementation of computer-assisted writing to help users in cases of lexical access disorder, or dysnomia.The topic is related to complex network theory and semantics of natural languages. But the project also affects psychology and psycholinguistics, provided that it deals with a language disorder; cognitive modeling, when trying to simulate the organization of memory; natural language production, because we want to model an interactive mechanism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Out of autoclave processes development for composite frames manufacturing with high production rate and low cost.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main objective of the COFRARE 2.0 project, answering to the call for proposal launched in WP B-4.3, will be to carry out process development for composite frames manufacturing with high production rate and low cost to provide a step forward in the development of aerostructures composite component for aircrafts such as Regional ones.The project will contribute to the development and validation of an advanced process for manufacturing composite fuselage frames, which will result in a significant reduction in overall production costs, component weight and manufacturing flow. In order to understand the feasibility of the technology to match the application, LRI and RTM processes will be validated and cost assessed through the application of the building block approach, meaning starting from Level 1 coupons to advance then to Level 2 elements to finally validate at test Level 3 of subcomponents to pass at the end to the realization of two demonstrators.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Elucidating pathways from hereditary Alzheimer mutations to pathological tau phenotypes' under Seventh Framework.

assistant: **Concept**

Alzheimer’s disease (AD) is a fatal neurodegenerative disease, manifested by a progressive loss of synaptic connectivity, neuronal death and memory impairment. AD affects 1 out of 10 Europeans aged over 65. There are no effective therapies for AD, in part because there is no proven molecular explanation of the steps leading from initial neuronal changes to synaptic defects and cognitive consequences.The two major hallmarks of AD pathology, Abeta plaque deposition and neurofibrillary tangles, arise from increased proteolytic processing of the amyloid precursor protein (APP) and microtubule destabilization due to tau hyperphosphorylation, respectively. Recent data indicates that generation of a beta-C-terminal fragment (b-CTF) of APP acts as a signalling event that induces tau phosphorylation and pathological redistribution of tau from axons to dendrites of neurons. This proposal tests the contribution of proteolytic APP processing, tau phosphorylation and synaptic dysfunction to AD in a human disease-relevant system using neurons generated from human induced-pluripotent stem cells (hIPSC) of AD patients. This hypothesis will be addressed by the following objectives 1) identifying the trafficking and signalling events that control b-CTF to tau signalling 2) define molecular interventions that inhibit b-CTF to tau signalling 3) asses downstream effects of b-CTF induced tau-phosphorylation on tau redistribution, dendritic function and synaptic connectivity.I will use state of the art microscopy and biochemical analysis combined with a short-hairpin screening approach in established neuronal lines (hereditary AD patient neurons) to identify key pathways involved in abnormal tau phosphorylation, and molecular and electrophysiological techniques to asses dendrite function and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ecological Utilization of Waste' (EUWaste) targeting Horizon 2020.

assistant: **Abstract**

On average one person in Europe uses 16 tonnes of material per year, of which 6 tonnes become waste. In 2010, total waste production in the EU amounted to 2,5 billion tons. From this total only a limited (albeit increasing) share (36%) was recycled, with the rest was landfilled or burned, of which some 600 million tons could be recycled or reused. From total amount 100 million tonnes is hazardous, containing heavy metals and other toxins. These substances make the waste particularly difficult to treat, as special processes are needed to deal with the hazardous components.Our Firm “Institute of Human Ecology-INEKO” (INEKO) developed an innovative solution that offers elegant and cost effective solution to utilization problem of hazardous waste, such as hazardous health care waste, oil-contaminated waste, pesticides, solid and liquid waste and sludge containing hazardous substances, and other kinds of waste (agricultural waste, unsorted municipal solid waste, etc.) EUWaste uses technology of gasification that allows utilizing waste of different type with a minimum environmental footprint and emission. Moreover, the use of gasification technology allows obtaining synthetic gas during the gasification process, which in turn can be used as a source of alternative energy for heat production. By using EUWaste, waste producers (e.g. health care facilities, pharmaceutical companies, petrochemical factories, etc.) and waste utilizers can improve their waste management and help to reduce health and environmental problems, reduce greenhouse gas emissions and avoid negative impacts at local level such as landscape deterioration due to landfilling, local water and air pollution, as well as littering.The objective of the EUWaste project is to conduct a feasibility study, which include
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Excellence, International, Intersectoral and Interdisciplinary doctoral training at Ecole Centrale Lyon in cotutelle with royal melbourne institute of technology AUStralia' (2014-2020).

assistant: **Innovation**

E3I ECLAUSion, a joint venture between Ecole Centrale de Lyon (ECL) and RMIT University, Melbourne Australia aims to build a highly nurturing and multi-faceted PhD training environment that would benefit the emergence (‘eclosion’) of the next generation - 10 doctoral fellows in 2 cohorts- of not only highly skilled researchers but also entrepreneurs with an international mind-set and interdisciplinary training.Specifically ECLAUSion, in line with the MSCA guidelines, the EU principles for Innovative doctoral training and the code of conduct, aims toi) Reinforce research excellence in ECL in partnership with RMIT and increase scientific output and international visibility; ii) Expand on existing doctoral programs by attracting highly promising international early career researchers to ECL and providing a nurturing environment with global reach (both in terms of scientific supervision, mentoring, working conditions, administrative support and social life). We envision two calls being organized, with 5 doctoral contracts per call being offered (total number of PhDs offered 10) so that every researcher can receive their PhD degree during the 5 years program;iii) Educate and train these ESRs; enhance their research and transferable skills with a 3i dimension by offering them Interdisciplinary research options, exposure to Industry (both at local, regional and international levels), and an inherently International network to maximise their opportunities and their emergence into successful professionals in their future careers iv) Leverage the existing rich biotech and ICT local/regional/global ecosystem and capitalise on it to develop new synergies between academia and the private sectors and more generally v) Strengthen EU-Australia research collaboration in key areas for in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Synthesis gas and C1-oxygenates formation by catalytic partial oxidation of methane' in the context of a Sixth Framework call.

assistant: **Objectives**

Natural gas utilisation has become an important research area in the last decade. The conversion of natural gas, mainly methane, into transportation fuels and added value chemicals is considered to be a promising alternative to make the use of this gas economically viable.This project is divided into two parts. Part 1 (outgoing phase at the University of California, Berkeley) explores the conversion of methane to synthesis gas by using Group VIII metal and Ni. We intend to focus on the reaction mechanisms and kinetics to improve in that way the catalytic performance and to control the relative rates of exothermic (combustion, partial oxidation) and endothermic reactions (reforming) so as to maximise their concurrent occurrence in space and time and thus minimise undesired hot spots. Part 2 (Institute of Catalysis and Petrochemistry, Madrid) is related to the partial oxidation of methane into C1-oxygenates (methanol and formaldehyde) through a single catalytic step.This process is of tremendous chemical and technological importance because it overcomes the synthesis gas generation, which is known to be a very expensive step. MoO3/SiO2 and V2O5/SiO2 materials will be used as a catalyst in our investigation. Our main goal is to increase the catalytic yield high enough to make this process economical and industrially feasible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improving Knowledge and Decision Support for Healthy Lifestyles', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Overweight and obesity are increasing at an alarming rate throughout Europe and this epidemic presents a major barrier to the prevention of chronic non-communicable diseases. Including the new EU countries, a total of over 200 million EU citizens are affected. All EU countries face a growing need for more effective therapeutic management of weight control, aimed at the reduction of overweight and obesity's most significant health consequences, which include hypertension, cardiovascular disease, type 2 diabetes, gallbladder disease, certain types of cancer and psychosocial problems. HEALTH PLUS intends to fill this gap through active support to healthcare professionals involved in weight control and in prevention initiatives.HEALTH PLUS will set up an integrated web-based knowledge management platform, assisting health professionals analysing the modern environment - which indirectly favours obesity diffusion - and offering certified and localized scientific information on food composition and lifestyle management. The system will support the examination of the patient's clinical profile and will match clinical data with lifestyle habits. The system output will support health professionals produce tailored nutritional plans and provide specialized counselling for efficient weight control.The HEALTH PLUS platform will include: a trustworthy context for information connected to the intersections nutrition/health and nutrition/lifestyle;- an intelligent knowledge management system for clinical and scientific information sharing among health professionals and researchers;- a decision support tool for healthcare professionals aiming at preparing patient focused nutrition/lifestyle plans;- a periodic control tool to follow the implementation of new nutrition/lifestyle plans- f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A Model-driven development framework for highly Parallel and EneRgy-Efficient computation supporting multi-criteria optimisation'.

assistant: **Objectives**

Complex, dependable and physically-entangled systems of systems must be supported by innovations to allow a significant reduction of the cost and complexity of system design targeting computing platforms composed of parallel heterogeneous architectures. Software development is one key challenge, as current programming tools do not fully support emerging processor architectures. Parallel and heterogeneous platforms are difficult to program and even more to optimise for the multiple conflicting criteria imposed by applications, such as performance, energy efficiency, real-time response, resiliency and fault tolerance. AMPERE addresses this challenge by incorporating model-driven engineering (MDE) as the key element for the construction of complex software architectures. MDE enables to efficiently capture system's functional and non-functional requirements, including multiple conflicting requirements, as well as enabling the use of domain specific model-driven languages (DSML) to further refine the description of cyber/physical interactions. The vision of AMPERE is that there is a clear necessity of developing a new generation of code synthesis methods and tools capable to implement correct-by-construction systems, in which the constraints captured by the system model are efficiently transformed to the parallel programming models supported by the underlying parallel heterogeneous platform, whilst providing the level of performance required. Moreover, AMPERE will provide computing software composed of a set of advanced run-time methods implementing monitoring and dynamic reconfiguration techniques, that will support the parallel execution to improve the overall system's efficiency, and guarantee that the non-functional requirements capture by the DSML are fulfilled. AMPERE