RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Systems Biology of Lipids Metabolism'.

assistant: **Concept**

Lipids are a group of biomolecules found in every living cell, being the main structural components of cell membrane. Despite being so widespread, lipids are the most elusive among the biomolecules, because of the difficulty they present to be analyzed with most of classical biochemical techniques. Nevertheless, recent advancements in high-resolution chromatography and mass spectrometry have started to throw light on this large class of compounds (the full lipidome is suspected to be of the order of hundred thousand species). Their fundamental role in cellular and organism physiology, both in health and disease, has started to be appreciated. In particular new functions of lipids are being discovered, including regulatory and signaling functions. Their deregulation has been recognized as a key factor in several metabolic diseases, ranging from diabetes, obesity, hypertension, to coronary, neurological and Alzheimer's diseases. Therefore, it necessary to investigate how lipids function within the cell physiology and to study the coupling between global metabolism and lipid metabolism. Systems Biology provides the natural framework for such a integrated study of lipid metabolism and biosynthesis pathway. We propose to develop a set of mathematical and numerical tools useful to investigate the structure and regulation of the lipid biosynthesis pathway and to identify the key parameters (enzyme activities and substrate concentrations) responsible for the alteration of the distribution of lipids. The results of this analysis will be communicated to experimentalists and the collection of further experimental evidence will be concerted. Collected data will be used, in turns, to refine the models. The interaction between theory and experiments will provide new insight and quant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel cross-linking enzymes and their consumer acceptance for structure engineering of foods' (CROSSENZ).

assistant: **Concept**

The project develops novel enzymatic tools for structure engineering of foods. The new technologies can be exploited for production of novel types of food products thus decreasing the need for structure stabilisers, such as gelatine. Discovery of novel enzymes will be carried out using high throughput screening methods. The target activities will be screened from plants and microbial sources and different production systems for the cross-linking enzymes will be investigated. The mode of action of the enzymes on model polymers (proteins, carbohydrates) on both molecular and structural level will be elucidated. The application potential of the enzymes in different food applications (meat, dairy and bakery products) will be assessed. Finally the consumer acceptance of the use of differently produced food enzyme ingredients and their different production routes will be determined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A 16-bit, 2 Giga -sample-per-second, Digital-to-Analog  Converter with 85 dB SFDR at Fout=400MHz'.

assistant: **Innovation**

A current steering  Digital to Analog Converter (DAC) is the enabling integrated circuit  for  high-speed waveform generation, with key applications such as UMTS cellular base stations, DOCSIS compliant digital TV broadcast, and RF test equipment. There is continuous demand for higher speed and higher resolution DACs that can generate waveforms at higher output frequencies with good linearity.The most important linearity metric of a high speed DAC is Spurious Free Dynamic Range (SFDR), and other measures such as Intermodulation Distortion (IMD) or Adjacent Channel Leakage Ratio (ACLR) depend on SFDR. Even with the state of the art DACs, SFDR drops very fast with increasing output frequency. Best 16-bit, high-speed DACs can achieve 95 dB SFDR at Fout = 1MHz, however, SFDR drops to less than  70 dB at Fout > 100 MHz. To generate more accurate waveforms  at high frequencies, it is crucial to identify, understand and address the dynamic error mechanisms of DACs.In a nutshell, the project proposal  consists of identification, avoidance and elimination of dynamic error mechanisms, demonstrated by a 16-bit, 2 Giga-sample-per-second (GSPS) DAC , on a 0.18u CMOS process. The focus will be on switch design, clock network design, output network design, switching algorithm design and built in self-test (BIST) structures. VLSI design tools and test equipment will be provided by Istanbul Technical University. Project funds will be used to support two researchers and, and multiple shuttle tape-outs. The project coordinator is familiar with the real technical issues involved, he has 13 years of industry experience in DAC testing, DAC design, and DAC design management at prestigious US corporations such as Texas Instruments and Linear Technology. He released numerous DACs to production
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Saving Time, Money and Lives Through Rapid Plug & Play Salmonella Diagnostics' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Salmonella is the major food poisoning agent but it takes 3-5 days to detect Salmonella with current state-of-the-art testing technologies. But since food manufacturers need to send out products to retailers before that, the pathogen might already have spread before it gets detected.DART is a new technology that allows immunoassays to have improved sensitivity in general. Its most pressing application is for the detection of Salmonella. DART is a fast detection kit of the Salmonella bacteria for food safety applications, based on a unique amplification reagent originally developed by us and enabled by the latest nano-medical advances. Our unique approach is based on bringing the benefits of one of the latest discoveries in nanomedicine to industrial pathogen diagnostics. We created our startup company, ABDART Diagnostics Lda., with the purpose of improving diagnostics. We have received an investment from Caixa Capital who invested €100,000 to help use get to TRL6. Our target market is the European Food Safety market sized at around €4 billion in 2018. Applying the global 20% share of Salmonella kits, this is around €800 million. To get to commercialization, we need to decide on a specific roadmap (Phase I Project). Then, we need to enter the commercial product development and testing phase (Phase II Project). We will sell Dart kits to our market right after the Phase 2 project when we have all the necessary validations and certifications. We plan to charge €15 per kit, which is in line with prices of DNA-based tests and slightly higher than immunoassay-based competitors, both of which take much longer to have the test results (days) than via our approach (hours).We can help reverse the main issue in Europe, which is that Salmonella outbreaks are not falling despite the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ocean margin research consortium' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

OMARC comprises ten European margin projects that provide a critical mass of European resources with links to European industry. We propose an accompanying measure to the ten existing margin projects with the aim of achieving synergies in research fields such as fluid flow and biosphere/geosphere coupling, seismic imaging methods, ocean drilling and long-term observatories, which concern several of the participating projects. These goals shall be achieved by a series of conferences and workshops that promote inter-disciplinary research. Moreover, OMARC will improve public awareness and management activities that help to safely explore our margin resources. OMARC will act as a link to international as well as national programmes and increase the visibility of European margin research with regard to industry and the general public.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Point-of-Care implementation of TB testing with ultra-fast Local Heating PCR' (PITBUL), addressing dissemination and exploitation.

assistant: **Impact**

The overall goal of this project is to bring the unique, ultra-fast Local Heating PCR technology and its current lab-proven prototype instruments from TRL 4 up to TRL 6 into clinical demonstration in tuberculosis centers in Italy, Latvia, and Tanzania. This will imply a fully automated workflow on the instrument and all necessary reagents onboard of the integrated disposable cartridge, and a cloud based software for tracking epidemiological patterns. The application, ultra-fast point-of-care testing (POCT) for tuberculosis (TB) as well as emerging TB resistance markers, is an unmet healthcare need, not only in Europe, but globally. About one third of the human population is thought to carry the pathogen. One patient with active TB can typically infect 10-15 others. In the EU, the highest incidence rates are observed in Eastern Europe and the Baltic region. Furthermore, a very recent surge has been observed in some EU countries, e.g. in Germany, mainly due to higher mobility and migration. On top of this, multi-drug resistant (MDR) TB strains are becoming epidemic, causing exploding treatment costs.Active tuberculosis needs to be rapidly detected at hospitals, in- and out-patient clinics, specialized TB centers, jails, community centers, and shelter facilities. Such a test should be highly sensitive and capture all of the clinically relevant mutations that confer resistance in TB; if only one mutation escapes detection, the wrong treatment decision might be made, leaving the patient infected and capable of spreading resistant pathogens. Therefore, a panel of multiplexed markers will be adopted to LPCR in this project. It is ultimately the project’s ambition to develop a European-based contender in the emerging molecular POCT system space. The integrated TB/MDR TB LPCR sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Variability and Trends in Atlantic Climate', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The NAO is affected by processes internal to the troposphere, and by “external” effects from the stratosphere above. In today’s climate, it is not understood what fraction of NAO variability is attributable to the stratosphere. This project is focused on understanding future climate—how the NAO will change, how jets and storm tracks will shift. It is an important challenge, because without a fundamental understanding of the physical processes involved, and without models that realistically simulate these changes over time, we are left with low confidence in climate projections—especially how climate will change over the large European sector. Thus, this topic is highly relevant to society.Following a 25-year highly successful career at a private research institute in the United States, I moved in 2012 to the UK to join the faculty of the University of Exeter. This CIG project is designed to help me to integrate into both the EU and the University system. To me, integration into the EU means developing a successful career as an educator and researcher, mentoring graduate students and post-docs, whilst maintaining an adequate stream of external funding to support these activities. This project primarily supports a graduate student, and is a key component of my integration into the EU. This integration is particularly challenging because it is not possible to take US-based funding to any institution out- side the US.This is a current problem with an urgent need for a solution. This problem is highly relevant to society, and the results have practical benefits. This proposal pushes the frontiers of research knowledge in two closely intertwined areas: 1) vertical coupling of the stratosphere to the troposphere (primarily the NAO), and 2) how state-of-the-art climate models d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Translating Institutional Systems' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The nature of cognition in real-life work settings has attracted the interest of scholars from different academic disciplines in the last decades. However, a professional activity that so far has received limited attention in research, despite its potential to produce considerable insight into the nature of cognition in large-scale organisations, is translation work in institutional settings. Institutional translation, e.g., in the European Union institutions, is characterized not only by institutional norms and regulations which are transferred across actors, artifacts, and time, but also by the ubiquitous use of technology. As such, it appears particularly well-suited for advancing the current knowledge of how cognitive processes, such as knowledge, remembering, and decision making, are distributed across actors in teams in institutional settings, as well as through their interactions with technology. This project aims to explore and model distributed cognitive processes by investigating social interaction and human-technology interaction in institutional translation settings, thus pushing the boundaries of current conceptualizations of distributed cognition in institutions. Ultimately, the study will result in the development of a theoretical model of distributed cognition in institutional translation settings that will inform future research into socio-cognitive aspects of cognition, interaction, and cross-linguistic communication. These research objectives will be pursued through the interdisciplinary integration of theoretical insights and methodologies from cognitive science, linguistics, anthropology, and translation studies. Specifically, it will combine ethnographic fieldwork with micro-ethnographic multi-modal interaction analysis to gather data on team inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Assembling Reconfigurable Endoluminal Surgical system' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The primary objective of the ARES Project is to investigate a revolutionary system for endoluminal surgery including the development of an experimental prototype. Surgical procedures of the future will evolve from today???s minimal invasive approach to ext remely high precision, localized and targeted endoluminal techniques. New surgical tools, capable of entering the human body through natural orifices or very small incisions and configuring themselves into complex kinematic structures at the specific site of intervention are required. Endoluminal surgery will encompass several distinctive steps: a) processing of previously acquired medical data (primarily images), simulation and planning of intervention; b) computer design of the optimal configuration of th e endoluminal robotic tool customized for the specific therapy at the target site; c) selection of modules necessary to reconstruct the robotic device inside the body; d) delivery of modules within the body to the desired site; e) (self) assembling and rec onfiguration of the resulting kinematic chain in order to form the pre-planned robot; f) extremely precise execution of the intervention; g) disassembly, recovery or biodegradation of the modules.In order to reduce the risks associated with such a visionar y and challenging goal and in order to achieve tangible results in a three year time frame, ARES will focus on a specific objective, i.e. the investigation and development of a reconfigurable surgical robot for the gastrointestinal tract. The project will primarily focus on critical theoretical and technological issues for implementing the above concept, including the kinematic analysis of the reconfigurable internal mechanisms; locking/unlocking systems; control and communication; design, fabrication and i nte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Extending the applicability of Cryo-EM for fragile biological systems via ultra-pure cryo-samples from Preparative Native Mass Spectrometry' (PNMS) targeting Horizon 2020.

assistant: **Abstract**

Precise structural, conformational, as well as chemical information of biological molecules forms the basis for comprehension and control of biological processes, including metabolism, pathological processes, and drug targeting. Cryo-electron microscopy (cryo-EM) has evolved into one of the leading methods for structural characterisation of folded proteins and protein complexes reaching atomic resolution through averaging. Thus, the unambiguous assignment of thousands of images to different oligomers, conformers, and fragments is a key requirement for high-resolution single particle cryo-EM. However, reliable preparation of homogeneous cryo samples remains one of, if not the, most important challenge in cryo-EM. Native mass spectrometry (native MS) allows to retain proteins in a near native state in an ultrapure gas-phase molecular ion-beam, providing complementary information on mass, composition, conformation and ligand binding sites. Preparative mass spectrometry (prep-MS) is able to generate ultrapure samples by soft landing of mass- and conformation selected molecules on surfaces for subsequent analysis. Here, we propose to implement preparative native mass spectrometry (pnMS), combining the strengths of native MS, prep-MS, and cryo-EM, to establish a new versatile pathway for comprehensive structural analysis of biological systems. We will design ion optics to couple a mass selected molecular ion beam from a commercial high-performance MS and a landing stage to add deposition capability. Initial experiments will focus on benchmark systems such as BSA and GroEL, before approaching more challenging proteins, including heat shock proteins (HSPs) and G-Protein coupled receptors (GPCRs). Ultimately, pnMS should enable the structural biology community to obtain a compre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mitochondrial dysfunction in neurodegenerative diseases: towards new therapeutics' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Mitochondrial dysfunction is a major hallmark of various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases or Amyotrophic Lateral Sclerosis (ALS). However linking mitochondrial dysfunction to the pathogenesis of some of these diseases still needs to be elucidated. Furthermore, in pathologies where this link is already established, the question remains whether specific targets or mechanisms involved in mitochondrial dysfunction will be amenable to therapeutic intervention. MitoTarget is an ambitious project aimed at providing solid data to better understand and exploit the circumstantial evidence linking mitochondrial dysfunction with neuronal dysfunction culminating in neurodegenerative disease. A 36 months translational research program will bring together a unique partnership between basic scientists, a seasoned team of clinical investigators and a SME that has identified a first-in-class compound, TRO19622, that targets mitochondria and has powerful neuroprotective and neuroregenerative activities. In parallel, and orchestrated by the SME that is the coordinator of the project, MitoTarget will bring together a more comprehensive insight into the mechanisms leading to mitochondrial impairments and establish their clinical relevance in a severe orphan neurodegenerative disease, ALS. If successful, it is expected that from this proof of principle a new class of therapeutic agents targeting the underlying mitochondrial dysfunction in neurons or their supporting cells will emerge. Results of the project have the potential to create a new paradigm for the drug discovery for neurodegenerative diseases.