RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The evolution of cooperative behaviour: Experimental tests of adaptive explanations and development of evolutionary theory' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The occurrence of altruistic cooperation is one of the greatest challenges for evolutionary biology. The problem is how can an altruistic behaviour, that is costly to perform but benefits other individuals, be maintained by selection? Recently, a great variety of cooperative traits have been discovered in microbes, which offers exciting experimental possibilities.This proposal aims to investigate siderophore production (SP), a cooperative trait and virulence factor of an opportunistic human pathogen, the bacteria Pseudomonas aeruginosa. Siderophores are agents produced by bacteria in response to iron deficiency to make host-bound iron available. SP is a cooperative trait, because it is costly for the individual to produce, but provides a benefit to other individuals who can also up-take the dissolved iron. This cooperative trait is exploitable by cheats who avoid the costs of SP but are still able to up-take the iron made available by co-operators.The objectives of the proposed work are to investigate conditions that favour the evolution and maintenance of SP by testing predictions of evolutionary theory. The objectives will be addressed by carrying out series of experiments that investigate the costs and benefits of SP under different environmental condition s and compare the relative success of co-operators and cheats when alone or in mixed cultures. The empirical work will be complemented with theoretical models that aim to develop evolutionary theory in this field. Furthermore, this work will study a co-operative trait that affects virulence in a human pathogen and, therefore, presents a novel opportunity for applying our understanding of social evolution to medical problems.The proposal directly addresses several objectives of the HRM Work Programme, namely: the ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CRISPR/Cas-based innovative electrochemical multiplexed immunosensor for specific detection of ovarian carcinoma biomarkers in urine' under Horizon Europe.

assistant: **Concept**

Ovarian carcinoma (OC) is a leading cause of cancer deaths in postmenopausal women worldwide. Unfortunately, it is diagnosed in the advanced stages (III/IV) with five-year survival rate of 20% and poor prognosis due to lack of distinct early symptoms. The current diagnostic tools (pelvic examination and imaging techniques) often fail to detect premalignant tumors and standard biomarker (cancer antigen 125) analysis show low sensitivity and specificity. The goal of this proposal is to develop a radically innovative modality in the field of early diagnosis of ovarian cancer. I propose cutting-edge CRISPR/Cas (Clustered regularly interspaced short palindromic repeats/CRISPR associated protein) technology-based molecular diagnosis as the next generation OC screening tool.The proposed CRINOVA project will apply the CRISPR-mediated biosensing approach for the first time combining with immunoassay to detect OC protein biomarkers (cancer antigen 125, human epididymis protein 4 and mesothelin) noninvasively in urine of early stage (I/II) OC patients through electrochemistry. The nucleic acid programmed nuclease activity of Cas effector protein will be activated upon sequence-based recognition of guiding RNA of CRISPR by a single strand DNA in the presence of biomarkers resulting in their highly specific and sensitive detection. The purpose of the project is linked to improving prognosis of OC patients, making a direct impact on enhancing their quality of life. This major objective will be achieved through a cross-disciplinary approach involving my wide experience in electrochemical biosensor development and the expertise of my supervisor on DNA nanotechnology and CRISPR-based biomolecular sensors. I have an excellent track record of scientific collaborations undertaking internat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Dematerialization of Fashion and France's Couture Propaganda during the 1960s and 1970s' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

FASHION IN IR aims to study the role of French women’s sartorial fashion in its international relations with a focus on both its interaction with the Common Market and its influence on the American mass market during the 1960s and 1970s. This approach is meant to open up the fields of Fashion History and International Relations History to each other. This will be done through the analysis of the influence of women’s sartorial fashion on the American mass market as well as within the context of the Common Market through the prism of the French authorities (industrial, governmental and diplomatic). In so doing, the added-value of diplomatic archival materials in the study of fashion–its influence and dissemination–will be compounded by the added-value of integrating fashion as an independent and unavoidable variable on the international stage. This project brings the political perspective of international relations as a new approach to the study of both the creative industry and the ways intellectual property can be appropriated by states as well as influence public authorities to act in certain ways at the behest of those creators of immaterial products such as fashion (both ideas and images). In so doing, the goal of this project is to generate a new interdisciplinary perspective pertaining to the study of European cultural heritage in the context of international and transnational competition of immaterial cultural goods. This project uses the renewal of an aid to couture program at the end of the 1960s in France as a case study of the instrumentalization of a part of European culture in the form of haute couture as a means to gain influence in the United States.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular mechanisms of arenavirus cell entry and antibody-mediated neutralization' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Over the last decades, multiple arenaviruses have emerged as zoonotic human pathogens. They cross the species barrier from their natural rodent hosts to humans and cause severe human disease. A key determinant of viral zoonotic transmission is the ability to bind the receptor molecules displayed on the surface of the host cell. Despite the threat these viruses cause to public health, little is known of how they infect the host and how they are targeted by the immune response. Furthermore, the treatment and prevention options are currently extremely limited. Using techniques in structural biology, virology, immunology and cell biology, the proposed work aims at demonstrating the molecular mechanisms by which arenaviruses attach to human cells and are neutralized by the humoral immune response. First, crystallographic analysis of viral attachment glycoproteins alone and in complex with functional cellular receptors will be performed. Second, recombinantly derived viral glycoproteins will be used as immunogens for generation of specific monoclonal antibody libraries. The co-crystal structures of viral glycoproteins with cross-reactive, neutralizing antibodies, carefully selected using cell-based assays, will reveal the structural basis of antibody-mediated arenavirus neutralization. Therefore, by analogy to the development of antibody-based therapy against Ebola virus, the outlined multidisciplinary investigation will enable the rational design of antiviral reagents and vaccines. The cross-disciplinary expertise, training and infrastructure available in the host and partner organizations will allow the Researcher to establish herself as a highly-skilled expert in molecular and structural virology. As an independent, multifaceted scientist, she will be able to make a tangib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Mobile Cooperation and Coordination Action - MOCCA' (MOCCA).

assistant: **Innovation**

The MOCCA coordination action will facilitate collaboration between projects addressing mobile and wireless issues, within the European Research Area (ERA), between projects in the ERA and research programmes in Asia and the US, and between researchers and projects in the ERA and their counterparts in the developing regions of the world. It will address this collaboration in the context of the research and development of future mobile and wireless systems, including the services arid applications they serve.MOCCA will facilitate European and international collaboration regarding research on future wireless systems and their applications. It will pave the way towards harmonised international standards for future mobile and wireless systems so that the systems meet the needs of users worldwide.The MOCCA approach is open to all. All interested ERA projects will be invited to participate in the activities organised by the project. Inter-continental collaboration with all major mobile and wireless research programmes and standardisation fora will be supported.MOCCA results will lead to the development of future applications, services and wireless networks, which meet the needs of users worldwide, building on Europe's strength in the mobile sector. In the long term, MOCCA results will improve the impact of the research results of the ERA wireless related projects on global standardisation activities and in the global market.MOCCA partners are (in alphabetical order): Alcatel, DaimlerChrysler, DoCoMo, Ericsson, Eurescom, France Telecom, INRIA, Motorola, Nokia, Ovum, SAP, Siemens, Telefonica and Deutsche Telekom.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'THE GREEN GENERATORS: MARU MOBILE ENERGY SUPPLY UNIT', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Off-grid power generation has been needed since long ago in isolated and remote areas where grid energy is not reliable or inexistent. In the recent years several advantages of on-site off-grid energy generation are being vastly appreciated in other segments due to price predictability, sustainability, business resilience, cost-effectiveness and environmental concerns. In Europe, a steady movement towards application of renewable energy is taking place. However, segments where temporary portable power supply are needed, the use of renewable energy proves more difficult and fuel generators are the dominant off-grid solution. The use of conventional generators is commonplace in the construction sector, predominantly running on gasoline or diesel. Although functional, the rate of CO2 and NOx emissions produced by fossil combustibles poses a challenge to conventional generators in view of the late European policies. We, Maru Systems, are an innovative company created in 2007 in the Netherlands and specialized in off-grid systems and renewable power supply solutions. We have developed MESU, a groundbreaking mobile hybrid generator powered by solar panels able to achieve a stunning 95% reduction on fuel consumption and CO2 emissions, that can replace diesel gensets in the construction sector providing a clean and efficient off-grid energy supply. We aim to carry out a Feasibility Study to plan the most suitable technical and commercial strategies to develop our product to commercialization level by 2020 and to concrete the business aspects of the project. We will also reach collaboration agreements with key distributors in the European market and confirm preliminary market traction.  In order to achieve these goals, we require a €2 million investment.Finally, through the comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'HEALTH IMPROVMENT IN SERBIA TROUGH REINFORCEMENT OF BIOMEDICAL SCIENCE AND TECHNOLOGY'.

assistant: **Innovation**

Institute for Medical Research (IMR), Belgrade, Serbia is a national leading centre in biomedical research. One of its major areas of expertise is establishment, development, standardization and implementation of new diagnostic and therapeutical approaches in combating various diseases. Malignancies are one the major causes of mortality in Serbia with the increasing trend. It is proposed here that IMRs' accumulated knowledge and experience, further reinforced through specific support actions (thematic priority 1. of FP6 - Life sciences, Genomics and Biotechnology for Health and FP6-2004-INCO-WBC/SSA ), is used in combating with this dramatic trend, by implementation of up-to-date diagnostic and therapeutic products and procedures.The above mission requires engagement of various experts in basic research, laboratory practice and clinics. Therefore mobilization of the critical human and material recourses in Serbia, as well as networking with other EU research centres will be accomplished. Both, visits by distinguished experts in health care and biotechnology from EU, as well as training of Serbian researchers in EU centers are planned. In order to reach EU medical diagnostic and therapeutic standards, IMR S&T capacities will be reinforced by availability of modern equipment. This project will attract the best young researchers and create new jobs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regulation of DNA resection, DNA repair and genomic stability by cohesin in undifferentiated Caenorhabditis elegans germ cells' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

DNA double-strand breaks (DSBs) are the most hazardous type of DNA damage threatening genomic stability. Thus, eukaryotes developed different mechanisms of DNA damage response and DNA repair pathways which are highly conserved, but not fully understood. To keep a control between error-prone (Non-Homologous End-Joining, NHEJ) and high-fidelity (Homologous Recombination, HR) mechanisms of DSB repair is essential for cell fitness, mainly exerted at the level of licensing HR by the initial step of the pathway known as DNA end resection. Therefore, a full study of this step is essential to understand genetic diseases, as cancer, with a high potential to direct future therapeutic strategies.Cohesin complexes are high conserved factors with several roles in preventing genome instability. Cohesin are a tripartite structure ring-like where only the kleisin subunit differ, the meiosis-specific Rec8 kleisin substitutes its mitotic counterpart Rad21/Scc1. It has been described roles for cohesin in chromosome segregation and DNA repair, but as short, all based in providing close proximity of sister chromatids. But little it’s known about an active function in DNA repair further tethering DNA molecules, e. g. participating in the decision of NHEJ/HR pathway, mediating early DNA resection, or targeting other repair proteins to damage sites regulating the DNA damage response, all aims of this proposal.We will combine the expertise of the applicant in cohesin in nematodes and the host laboratory in DNA repair to shed light and compare the active contribution in DNA repair of the SCC-1- and REC-8-cohesin complexes. The use of Caenorhabditis elegans as model system will provide a portal to the study of systemic DNA damage response mechanisms in a tissue- specific way, here the mitotically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tumour Heterogeneity and Somatic Evolution of Unstable cancer genomes' (THESEUS).

assistant: **Concept**

SummaryThe majority of metastastic solid tumours remain incurable. In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH). Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome. However, despite increasing knowledge of tumour diversity, there is limited insight into the mechanisms driving genomic instability and ITH or the processes that shape cancer genome evolution over time and space. Many animal tumour models fail to recapitulate patterns of genomic instability witnessed in human tumours, limiting insight into the forces that shape tumour evolution in vivo. We have found evidence for parallel subclonal evolution, resulting in the same gene or signal transduction pathway being subject to distinct inactivating or activating somatic events in different regions of the same tumour (Gerlinger NEJM 2012). These data suggest that in-depth analysis of tumour evolution may help define routes through which tumours must progress, offering opportunities for novel therapeutic approaches. We will develop new animal models of ITH, by developing knock-out strains for two suppressors of replication stress and CIN, recently identified in our laboratory (Burrell Nature 2013). These models will be used to study cancer evolution in order to decipher the impact of selection pressures, such as DNA damaging agents and cancer cytotoxics, on genomic complexity and diversity in emergent resistant subclones. In addition, through combined cancer informatics and functional genomics approaches we aim to identify novel mechanisms driving tumour heterogeneity and biological processes that permit the propagation of heterogeneous cells using n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Verification through Accelerated testing Leading to Improved wave energy Designs' (VALID) under Horizon 2020.

assistant: **Objectives**

The VALID project will develop and validate a new test rig platform and procedures for accelerated hybrid testing that can be used across the wave energy sector to improve the reliability and survivability of the components and subsystems that form Wave Energy Converters (WECs). The methodology for accelerated hybrid testing combines both physical testing (physical test rigs) and virtual testing (simulated environment, numerical models and data). The VALID Hybrid Test Platform (VHTP) will become the interface that allows for seamless accelerated hybrid testing. With the long-term goal of establishing a standard for future use and making a step-change impact on the sector, the new test rig platform and methodology will be validated for a variety of WECs, critical components and subsystems through three different user cases.   Often faults in component and subsystems are detected through extensive and costly sea testing in late stages of device development (high TRLs) and finding a problem at late development stages can add significant cost and delays to initial schedules, eventually leading to company’s bankruptcy. Sound testing methods are thus needed to reduce the uncertainties, increase confidence in results, assist and guide the concept and subcomponents design, and thus largely assist in the decision-making progress. The new hybrid testing platform with open access for models, testbeds and improved data management are all necessary to lower the cost on future technologies. VALID assembles the full value chain required from methodology and platform development (AVL, Aquatera), technology development (Corpower, IDOM, Wavepiston), LCOE (Julia F Chosaz Consult Engineering) to certification bodies (RINA-C)  in order to develop an integrated solution with support from RTO