RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Beneficial application of protein-free medium in industrial processes with mammalian cell cultures producing biopharmaceuticals'.

assistant: **Objectives**

The objective of this project is to demonstrate the applicability and the economic and practical advantages of protein-free medium using the new effective protein-free SMIF media line and a corresponding cell adaptation protocol which shall be applied to current industrial processes with mammalian cell cultures producing pharmaproteins and vaccines. There is an increasing demand from clinicians and patients for human therapeutics manufactured by processes fee of any component of human or animal origin. In addition, the worldwide competition induces manufacturers to currently improve their process strategies and to adapt them to the latest standard. Especially, the step to the use of protein-free media is one of the expectations that have been frequently pointed out and that contains essential economical benefits. The improvement of biopharmaceuticals as proposed for this demonstration project is of highest public interest with respect to medical standards. Due to the broad spectrum of methods and production processes used by the different European pharmaceutical companies, demonstration of the application of protein-free media needs the concerted effort and cooperation of highly competitive manufacturers and research institutes involved in the production of biopharmaceuticals. The four groups that have joined together will unite their specific knowledge and expertise into a multi-disciplinary approach that will cover the major application aspects in mammalian cell cultivation and production. By focussing activities of several competitive European industrial companies and the corresponding biotechnological research, the advantageous and reliable application of a new protein-free culture media line combined with a necessary adaptation strategy for conserving process speci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Developing Fish Skin as a sustainable raw material for the fashion industry'.

assistant: **Concept**

The Fashion industry is currently going through a significant change in its approach towards sustainability, aiming to transform from a wasteful and polluting industry into the into a cleaner and more circular sector.  In FISHSkin, our research concentrates on developing a new category of raw material for fashion – fish leather. we aim to amalgamate the Mariculture and Fashion industry by using both the fish flesh and skin as viable, economically useful products. While fish leather was used for centuries by indigenous people in Northern Europe and Asia, it was pushed aside by hides which offered better characteristics. Today, however, circular economy principles combined with state-of-the-art technology and changing consumer tastes – allow us to challenge existing fashion assumptions and explore the viability of fish leather is this industry. Through secondments and network training events we will generate knowledge cohesion from different disciplines: Fashion design, Material science and Marine biology where academic and industrial experts will strive to develop new techniques and methodologies for a market take up of fish leather at an industrial scale.


**Keywords:** Fashion design, tanning, fish skin, sustainable fashion, design based materials, textile printing, surface treatment, circular economy, Responsible sourcing, renewable raw materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The integration of intermediate pyrolysis and vapour gasification to create and effective and efficient biomass-to-energy system for combined heat and power' in the context of a Seventh Framework call.

assistant: **Objectives**

The use of biomass, and waste, as a fuel for the production of energy in the form of electrical power and heat has in recent years come to be recognised as a key element in the move to sustainable forms of energy as part of the strategy to combat climate change. Throughout Europe, challenging targets for the provision of bioenergy and reduction in carbon emissions have been identified but progress towards those targets is extremely slow.Thus, to enable a concerted, informed, and joint development this project brings together a leading European Bioenergy Research institute (EBRI) that has new key patents in the clean and efficient thermal treatment of biomass based on the Intermediate Pyrolysis process, with two European SME companies recognised for their respective technical and engineering expertise in the provision of thermal  treatment plant (WGD) and gasifier technology (WWAG) respectively.  A Demonstration installation has recently been approved for funding at EBRI which not only gives significant added value (€15M) in terms of the stand alone technology installations but, more importantly, provides a unique opportunity to integrate the pyrolysis and gasification processes to produce a cost efficient flexible,optimised, linear process for power and heat production from biomass and waste.The aim of the programme is therefore, through a programme of laboratory and demonstration scale testing, to fully integrate the intermediate pyrolysis and gasification processes to form the PYROGAS concept for power and heat from biomass, and to demonstrate its successful operation on a range of feedstocks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pulmonary endothelial dysfunction before and after open heart surgery in children - a comparison of the effects of endothelium-dependent and -independent vasodilatation' (1994-1998).

assistant: **Concept**

Central problem addressed by the project: --transient pulmonary endothelial dysfunction with significant morbidity and mortality following cardiopulmonary bypass in patients with congenital heart disease --unknown relation of preoperative to postoperative pulmonary endothelial dysfunction Objectives: --examination of the components of pulmonary endothelial dysfunction before and after heart surgery Content: 1 design: --single centre prospective cross-over randomized study of the effects of various agents 2. patients: --patients with pre-operative pulmonary hypertension at cardiac catheterisation and following heart surgery 3. measurements: --oxygen content hemodynamic pressure measurements for shunt and oxygenation calculatgons --cardiac output and pulmonary vascular resistance using a dedicated resperatory mass spectrometry --cyclic GMP levels as an indirect marker of nitric oxide production 4. two cross-over protocols containing different chronological application of: --no substance (baseline) --infusion of substance P for examination of endogenous release of NO --infusion of L-Arginin for examination of NO-mediated response --inhaled NO for examination of sensitivity of pulmonary vascular smooth muscle Summary: The project proposes to examine the potential components of pulmonary endothelial dysfunction in patients with congenital heart disease before surgery, and how they are modified in the same patient afterwards in order to reduce morbidity and mortality associated with postoperative pulmonary hypertension.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'TRANSPORTNET - European Transport Research and Education Network - Training Courses' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Good and reliable transportation systems contribute to economic growth and development, to cultural and social exchange and to the improvement of human relations. Mobility of people and goods is thus a central issue in today's societies. However, the increasing flows of transport also generate considerable external costs, such as: environmental damage, accidents, congestion, infrastructure, damage, etc.The education and training of young researchers in this field is one of the major targets of TRANSPORTNET, a network of eight European leading universities involved in transport research and education: Universiteit Antwerp (UA), Instituto Superior Tecnico Lisboa (IST), Universität Karlsruhe (IWW), Universita di Genova (UNIGE-DIEM), Ecole Polytechnique Federal e de Lausanne (EFPL), Technische Universiteit Delft (TUD), Laboratoire d'Economie des Transports Lyon (LET), and University of the Aegean (STTAEGEAN).The network was setup in 2003 having its main purpose the co-operation in the field of transportation research and research training. This is and will continue to be realised by the exchange of Professors in the Master, PhD and post-doctoral programmes, the exchange of students, the organisation of summer courses and master classes, the co-operation in research programmes, and the creation of a European PhD programme in Transportation.It is the strategic option of the network to have a consistent approach between the research streams, where early stage researchers will develop, and the training courses where synergies can be obtained through the interaction with practitioners and more senior researchers. The two instruments are seen as rather complementary for the consolidation of research strengths in transportation.As part of this strategy the network submitted a prev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EXOsomes as a new strategy in Assisted Reproductive Technologies: tracing maternal nanomessengers to improve pregnancy outcomes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The current embryo in vitro culture conditions used in most laboratories of assisted reproductive technologies (ARTs) allow the embryo to develop to the blastocyst stage and to achieve pregnancy. However, the quality of those embryos is suboptimal compared to the in vivo ones and the obtained pregnancy rates are low. The lack of maternal signals, during the in vitro period has been postulated as a main reason for these suboptimal results. There is increasing evidence of the role of the oviduct exosomes (oEXs) as mediators of the early maternal-cross talk. Recent data revealed the first oviduct-derived EXs protein signature and their important roles in embryo-oviduct interactions. In the present proposal, using bovine model, we aimed to: (i) Evaluate whether the presence of the early embryo in the oviduct could modulate the oEXs proteins, mRNA and miRNA content depending on its stage of development. (ii) Assess whether the embryo quality (good or poor embryo) affect the content of EXs secreted in vitro by the oviduct epithelial cells. (ii) Assess the effect of in vitro culture with oEXs on the embryo development and quality. To accomplish these tasks, an ambitious, realistic, work plan has been designed based on the excellent background of the Fellow, and the training she will receive, the expertise of the supervisor in female reproductive physiology and the infrastructure within the host lab for conducing all the experiments with most appropriate tools. This will ensure that the Fellow completes the scientific objectives of the proposal, communicate and disseminate the results to the scientific and public, while acquiring new set of skills that will have an important impact in her career development. If the beneficial effect of oEXs on embryo development is recapitulate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Somatosensory signals and the “I” of conscious experience in healthy subjects and neurological patients' (SELF-CONSCIOUSNESS) under Seventh Framework.

assistant: **Objectives**

The present project will address key questions on how the representation of the body by the brain contributes to the sense of self. I will intend to study the contribution of somatosensory inputs to bodily self-consciousness in healthy subjects and polyneuropathic patients. Virtual reality and cognitive science in combination with muscle tendon vibrations and brain imaging techniques (high density electroencephalography (EEG)) will be used to reach this goal. I propose to investigate this in the context of the recently described “full body illusion” that uses visuo-tactile conflicts to alter crucial aspects of bodily self-consciousness such as “what we feel as our body” (self identification) and “where we experience our body to be” (self-location). The “full body illusion” will be associated with vibrations applied at the lower limbs in order to determine whether bodily self-consciousness is altered by such somatosensory noise in healthy subjects. The vibration technique reproduces to some extent the degradation of proprioceptive inputs that is generally linked with polyneuropathy. In order to further understand the contribution of the somatosensory system to bodily self-consciousness I also plan to carry out the above described experiments in polyneuropathic patients. This proposal is highly original in its combination of high-quality quantitative psychophysical and neuroimaging studies of fundamental body perception with deep neuroscientific and philosophical questions about the neural basis of the self. This research will be of great relevance not just for science, but also for diagnostics in neurology and psychiatry, neurorehabilitation of polyneuropathic patients, virtual reality applications and man-machine interfaces. Finally, the neuroscience of self-consciousne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A Learning-from-Prices view of Inflation and Business Cycles'.

assistant: **Innovation**

The Eurozone is currently facing a sudden and sharp increase in inflation. Whether inflationary pressures will persist and what will be the cost of an eventual monetary tightening crucially depends on inflation expectations. The aim of this project is to provide theoretical and empirical support to a new channel, through which inflation may persistently shift business activity. The project sheds new light on how market prices influence consumers perceived inflation and how this may allow for the transmission of monetary policy even in the absence of rigidities in firms pricing. It shifts the focus from a traditional firm-centric to a (complementary) household-centric view of money non-neutrality. It shares the spirit of a recent trend in central banks efforts in getting a better appraisal of the importance of consumers expectations, after decades of a strict empirical focus on firms pricing. The project consists of five working packages (WP) based on the idea that households inflation perceptions, driven by actual market prices, can be a major source of the business cycle. The first WP proposes a new theory where output-inflation co-movement relies on consumers price hunting in response to perceived inflation, causing a counter-cyclical gap between posted and paid prices inflation. The second and third WP aim at validating the mechanism using large datasets on consumers spending and retail trade. The fourth presents a new model where consumers learn from inflation about future economic prospects on which all have dispersed foresight. The fifth will estimate this model on survey data. The key novelty of the project is studying, not only how expectations move market outcomes, as typical in the literature, but also how these feed-back to expectations through prices in a fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Absolute dating of the variations of the Scandinavian Ice Sheet and correlation of events since the Eemian in north-east Germany'.

assistant: **Innovation**

Research into the extent and chronology of the Scandinavian Ice Sheet (SIS) has been conducted for > 150 years, yet the general pattern and timing of SIS advances is only understood in a few areas that are spaced apart by several 100s of kilometres. Thus, a realistic and full understanding of ice sheet dynamics and its response to, and interactions with, palaeo-climatic conditions during the last glacial cycle (c. 110-11.5 ka) is still very incomplete. This is largely due to a pronounced lack of chronology in several parts of the Northern European Plain (NEP) around the Baltic Sea Coast, in turn the result of the absence of suitable material for most dating methods. We here propose to use a combined approach of detailed sedimentological laboratory and field investigations and OSL-dating at selected key sites in North-East Germany, a much under-researched area compared to other areas on the NEP. This will enable a tight chronology for the emplacement of various glaciofluvial, glaciolacustrine and glaciomarine sediments that are found on this part of the NEP to be established. The study areas were chosen because existing numerical dates are absent or, where they exist, provide contradictory evidence. Likewise, existing numerical dates from the surrounding areas on the NEP require similarly detailed dates in order to allow correlations to be made and also to fill gaps in our knowledge. The data resulting from the proposed project would ultimately allow numerical modellers to tune their models according to the field evidence. Only if such models are well-constrained by palaeo-evidence can they be expected to reliably predict future climate change. Thus, the proposed project is of immediate societal interest.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'VOLUME EXTRACTION AND ENCAPSULATION OF FLAVOUR CHEMICALS, PHARMACEUTICAL SUBSTANCES, BIO-CHEMICALS AND ENZYMATIC SYSTEMS' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

There is a growing trend in favour of botanical extracts for a number of large-scaleuses, including flavourings, fragrances, and pharmaceutical or medicinalpreparations. Consumers are now more aware of green issues and are rejectingartificial substances in favour of their natural alternatives. In addition, the searchfor new drugs is now focusing on botanical molecules, particularly from rain forestsin developing countries. However, there are several problems associated withconventional volume solvent extraction methods, which until now have restrictedthe wider use of such substances The need to match solvent with the physicalproperties of the desired extract has led to the use of environmentally damagingorganic solvents, such as dichloromethane. Residual trace organic solvents inproducts can cause allergenicreactions in consumers Conventional solventextractions often lack specificity, and produce relatively low yields.This project will therefore develop an extraction process which combines an initialhydroalcoholic solvent extraction, followed by extraction with a supercritical fluid.The second stage of this technique will use a high pressure, counter-current liquidextraction column. This will be a non-toxic, environmentally sound process offeringhigh yields and specificity. The project will also develop a continuous, as opposedto batch process. This is a necessary goal in order to achieve the greatest possibleeconomic viability for the system. Development of a truly continuous supercriticalfluid extraction (SFE) process has been attempted many times before, but theassociated engineering problems have curtailed such development.The work will centre around various test botanical extracts, which have beenchosen for their commercial potential as well as for technical reason