RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'An integrated modular service for microfluidics'.

assistant: **Innovation**

The vision of µBUILDER increase the commercial success and competitiveness of European SMEs by introducing mixed technology devices and sub-systems as key components in their products. In order to achieve this vision µBuilder will develop and provide industry, especially SMEs, but also academic research an easy and cost-efficient access to mixed technology manufacturing, design & engineering services and advanced tools. The focus of the service is on mixed technologies for micro fluidics.The goal of the µBUILDER is to establish an integrated service, offering:- Cost efficient access to mixed-technologies based on:a) silicon/glass technology through multi project fabricationb) polymer technologyc) various qualified add-on processes, like bio-functionalisation, functional films, hydrophilisation, etc.- Easy access to qualified microfluidic components and systems through a modular development platform- A commercial infrastructure for design & engineering services, advanced tools and mixed technology manufacturing through one single customer interface- Pre-normative standards for the integration of different components and technologies, specified in a master design handbook- Joint promotion and training activities in order to ensure that the service will be able to reach the whole European marketThe µBUILDER project will deliver:- A technology platform for the realization of mixed silicon, glass and polymer devices and systems- A master design handbook- 7 qualified add-on processes to add flexibility and functionality to the standard processes offered- 2 application oriented demonstrators- 7 modules for the micro fluidic development platform- 12 MPW runs completed- A survey and a roadmap on mixed technology- 3 Coventor foundry modules/process design kits- Training modules f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of neural circuits in the prefrontal cortex' to be submitted under Horizon 2020.

assistant: **Abstract**

The prefrontal cortex (PFC) is important for a wide range of cognitive behaviours and is impacted in numerous neuropsychiatric disorders. The PFC is thought to function as a key buffer for working memory, allowing us to store and manipulate information across time. The PFC is therefore critical to our ability to link past and future events. To do this the circuitry of the PFC must sustain task relevant neural activity across the delay period, when information is stored in memory. This process is thought to occur through recurrent networks in the superficial layers of the PFC, however the organization of these circuits remains poorly understood. This proposal will apply cutting edge optogenetic methods to produce dense, single-cell connectivity maps to elucidate the circuit architecture of the mouse PFC, providing insight into the circuit mechanisms that support mnemonic coding. It will also explore the development of this circuit, to better understand how refinement of connectivity gives rise to adolescent enhancement in PFC dependent cognition. These findings will also test key computational predictions into the mechanisms that support delay period activity. They will therefore be of broad interest to cellular, systems, computational and cognitive neuroscientists.


**Keywords:** Neural Circuits, Optogenetics, Cortex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Construction Recycling Technologies for High Quality Cement and Concrete' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives and content Cement and concrete manufacturers have a strong need for sufficient supply with quality raw materials at acceptable expenses. The supply from quarries and gravel pits is running short, due to decreasing resources and environmental restrictions. In addition, the generation of demolition wastes is increasing with dramatic growth rates, at the end of the century at least 175 M. tons annually. European Directives on waste dumping and landfills are very strict, the dumping costs are increasing all over Europe. So the construction sector has an imperative need for reusing building rubble. Until now it is limited only to subordinate purposes though its potential performance is much higher. With respect to total building rubble recycling, the project considers as well the coarse portions for producing high quality concrete as the reuse of fines <4 mm. i.e., about 40% of all demolition waste, for cement manufacturing. There is no evidence that studies for this purpose have been developed in Europe or elsewhere. The first aim of the project is to develop appropriate technologies for manufacturing high quality cement and concrete, using representative demolition waste in different countries with a variability of composition, contamination and material properties: - Research on mechanical, physical and chemical properties (e.g. strength, creep and shrinkage, leaching tests) with emphasis on durability behaviour (e.g. freeze/thaw resistance) will be carried out to prove the applicability and limiting conditions. -Prenormative requirements and guidelines and furthermore design specifications for recycling will be deduced from the results. Achievements of this project will bring solutions to all aspects of the product life-cycle: Raw material - Processing - Manu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamic dialogue modelling' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

With the prevalence of information technology in our daily lives, our ability to interact with machines in increasingly simplified and more human-like ways has become paramount.  Information is becoming ever more abundant but our access to it is limited not least by technological restraints.  Spoken dialogue systems address this issue by providing an intelligent speech interface that facilitates swift, human-like acquisition of information.The advantages of speech interfaces are already evident from the rise of personal assistants such as Siri, Google Assistant, Cortana or Amazon Alexa. In these systems, however, the user is limited to a simple query, and the systems attempt to provide an answer within one or two turns of dialogue. To date, significant parts of these systems are rule-based  and do not readily scale to changes in the domain of operation. Furthermore, rule-based systems can be brittle when speech recognition errors occur.The vision of this project is to develop novel dialogue models that provide natural human-computer interaction beyond simple information-seeking dialogues and that continuously evolve as they are being used by exploiting both dialogue and non-dialogue data. Building such robust and intelligent spoken dialogue systems poses serious challenges in artificial intelligence and machine learning.  The project will tackle four bottleneck areas that require fundamental research: automated knowledge acquisition, optimisation of complex behaviour, realistic user models and sentiment awareness.  Taken together, the proposed solutions have the potential to transform the way we access information in areas as diverse as e-commerce, government, healthcare and education.


**Keywords:** statistical spoken dialogue systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'REGENERATING LARGE BONE DEFECTS'.

assistant: **Objectives**

In the field of orthopedics and maxillo-facial surgeries, there is still no satisfying solution to repair critical size bone defects. Autograft, which is the current gold standard, presents several drawbacks, including prolonged pain on donor site and higher infection risks. It needs to be replaced by efficient, safe and easy-to-use strategies. Some synthetic bone grafts are providing mechanical and osteoconductive properties, but there is a need to introduce a bioactive molecules, such as a growth factor or a peptide, to trigger actively bone repair. These “orthobiologics” products are appealing since they trigger stem cell activation in situ. There are several approved products containing orthobiologics on the market for bone regeneration, but the physiological delivery of orthobiologics remains a challenge: severe adverse effect have been reported due to the supra-physiological dose of biologics used. In addition these product do not provide structural properties which is necessary for critical size defect reconstruction. Ideally the carrier for the bioactive molecules should be appropriate and enable a spatially/temporally-controlled molecules delivery with physiological dose.Our nanomedicine technology consists of an osteoinductive biomimetic films that can be deposited on architectured implant of any shape and material (ceramics, polymers, metals). The aim of REGENERBONE is to advance our technology toward a clinical application in maxilla-facial surgery and orthopedics. This will be done by conducting pre-clinical trials in large animals, doing a market search, securing the sourcing of the film components and building a business model. The successful results we obtained recently in the frame of the ERC BIOMIM and Proof-of-Concept OSCODI are the basis for REGENERB
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integration of interoperable intermodal horizontal transhipment techniques in inter-modal transport operations' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The proposal aims at promotion of specific transfer technologies in intermodal transport. By this improved systems, the transfer of loading units between different modes shall be executed with less costs and improved reliability. Furthermore, new operational approaches in road-rail intermodal transport are introduced by such horizontal transfer technologies, mainly the possibility to organise economic road-rail transport on shorter distances. Furthermore the integration of such systems in existing operational systems shall be examined. The influence of these technologies on the design of current intermodal transport equipment and loading units will be furthermore evaluated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'FUnerals as public Services in long Eighteenth century London' to be submitted under Horizon 2020.

assistant: **Abstract**

The research aims to understand the organization and functioning of services for the community in early modern London through a concrete case study, namely the ways in which funerals and burials were managed during the long eighteenth century (1670-1852). I selected the case of London in order to complete a long-term comparative study that began with my doctoral research. By extending my research to London, I will be able to compare it with Paris and Naples, which I analysed in my previous research experiences. These three capitals were the most populous cities in Europe during the study period. How did these multifaceted societies solve issues of collective interest before the birth of modern public services? Which elements did modern public services inherit from them? In order to ask to these questions, I will make use of an interdisciplinary methodology taking advantage of expertise acquired at Birkbeck, University of London, under the guidance of an excellent supervisor (Professor Vanessa Harding). Working in a large, many-faceted academic entity such as the University of London will be a considerable milestone in my career. I will acquire a strong comparative methodology that is essential for my long-term research purpose. Furthermore, I will attain important competences in both educational and research policies, as well as a better understanding of administrative issues, in English-speaking countries, which still differ considerably from the countries where I worked until now (Italy and France). Parallel to the program of research and training, I will put in place a series outreach activities that will enable me to engage with a wider public and share the relevance of historical research for an understanding of today’s problems and the development of adequate resp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unravelling ApoE4 contribution to tau-mediated synaptic degeneration in AD by combining advanced proteomics and super resolution microscopy' (SynApoE) under Horizon Europe.

assistant: **Objectives**

Alzheimers disease (AD) is one of the biggest scientific and socio-economic challenges of the 21st century. Currently, there is no cure. Aggregates of amyloid- and tau protein, along with neuroinflammation/gliosis, are hallmarks of AD that lead to synaptic and neuronal loss as the basis for cognitive decline. The latter correlates closely with the brain distribution of tau aggregates, providing a strong incentive to investigate a link between tau accumulation and synaptic degeneration.Brain apolipoprotein E (ApoE), mainly produced by astrocytes, is essential for lipid transport to neurons and synaptic functions. ApoE4 isoform is the strongest genetic risk factor for AD and contributes to tau-mediated neurodegeneration. Determining how ApoE4 controls tau-mediated synaptic degeneration is thus essential to understand AD and develop efficient treatments, yet this requires fine characterization of ApoE4 functions at tau-damaged synapses with a synaptic resolution.SynApoE will test in 3 work packages the hypothesis that ApoE4 worsens tau-mediated synaptic degeneration by altering the astrocyte/neuron interactions at the synapse:1: SYNAPTIC CHANGES. Identify directly at tau-damaged synapses the ApoE4-mediated structural and functional synaptic changes;2: PROTEIN PLAYERS. Identify the protein players underlying these structural and functional synaptic changes;3: MECHANISMS. Discover the mechanisms through which ApoE4 promotes tau-associated synaptic degeneration, based on the protein players identified in WP2.SynApoE aims to decipher how ApoE4 drives tau-mediated synaptic degeneration, providing a deeper understanding of AD pathophysiology. SynApoE achieves unprecedented synaptic resolution by combining advanced proteomics, super resolution microscopy at synapses, electrophysi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'IMPROVING THE EFFECTIVENESS AND SAFETY OF EPIGENETIC EDITING IN BRAIN REGENERATION' (REGENERAR) targeting Horizon Europe.

assistant: **Abstract**

The central nervous system has a limited capacity for self-repair. Therefore, technologies to replace lost neurons after an injury, including stroke or neurodegenerative diseases, are of great need. The project REGENERAR aims to develop a non-viral delivery  formulation up to TRL4 for the delivery of an epigenetic reprogramming formulation to reprogram glial cells into neurons. The in vitro safety and targeting of the formulation will be tested against glial cells and organotypic cortical slice cultures. Several routes of administrations will be tested to enhance the accumulation of the formulation in the brain. In addition, the in vivo safety, elimination, targeting and epigenetic reprogramming will be evaluated. In addition, toxicological studies will be performed in GLP conditions to evaluate both in vivo systemic and local (brain) effects of the formulation. The development of the non-viral formulation will take in account the contributes of key stakeholders in the area of gene editing, health institutions, patient associations, among others. A roadmap will be developed for upscaling innovation to higher TRL´s upon the end of the action.


**Keywords:** gene editing,  epigenetic reprogramming,  non-viral delivery systems,  spatial transcriptomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'HIGH BANDWIDTH LONG DISTANCE UNCOMPRESSED AUDIO-VIDEO SIGNAL TRANSMISSION SYSTEM DEVELOPMENT' (LIGHTWARE), addressing dissemination and exploitation.

assistant: **Impact**

Professional computer graphics and video applications’ tendency is to improve display resolutions for desktop monitors, projectors and consumer TV sets. Today HD resolution is a de facto standard used in TV broadcasting and computer displays. The so-called Ultra HD 4K pixel resolution has just started to spread in the industry, and NHK Japan's national public broadcasting organization announced to use 8K video standard during 2020 Winter Olympic Games. Today there is no existing product that extends UHD 120Hz 3D video signal, or other “retina display” type computer video content in an uncompressed and low latency format. The current video standards (DisplayPort 1.2, HDMI 2.0 and SDI 6G) define copper cable based connectivity, but they are limited to a distance of a few meters. Our innovative 40Gbit optical extension helps to cope with this problem and deliver a complete solution for these clients for up to 10 km distance. It consists of (1) a fiber optical extension standard enabling UHD and UHD-2 signal extension without latency, (2) extension devices extending DisplayPort 1.2 video signals for up to 10 km distance, and (3) a 40 Gigabit matrix switcher platform. The most relevant demand comes from digital cinemas, mass-media, festivals, concerts, openings, broadcasting of special events (particularly sport), museums, interactive exhibitions, 3D projections etc. Additional targets are medical and industrial market segments. We, Lightware Ltd., are a leading manufacturer of DVI, HDMI and DisplayPort matrix switchers, signal extenders and accessories for the professional audio visual (A/V) market with a headcount of about 130 persons and an annual revenue of 10 million EUR. We plan to commercialize our new product through our offices and distributors in more than 40 count
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'All-optical photoacoustic imaging for neurobiology' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Measuring the electrical activity of neurons in vivo is of paramount importance to understand the underlying principles of the brain. Current imaging techniques fail to capture this activity across the entire brain with sufficient spatial or temporal resolutions, while leaving brain tissue intact. Non-linear fluorescence microscopy, the most widespread optical imaging modality in system neurobiology, provides optical diffraction limited resolution and high frame rate, but is limited to shallow depth due to light scattering in tissue. Single-neuron activity in brain regions deeper than one millimeter can therefore not be probed. Combining widefield optical excitation and ultrasonic detection, photoacoustic imaging has emerged in the last decades as a powerful technique to image of optically contrasted objects embedded deep inside biological tissue. It relies on the emission of ultrasound waves upon the absorption of a light pulse. As ultrasound are only weakly scattered when propagating in soft tissue, optically absorbing structures can be reconstructed from the sole measurement of the ultrasound field at the tissue surface.The highest spatial resolution is currently achieved using optical sensors of pressure waves, which exhibit a better sensitivity to high ultrasound frequencies compared to conventional piezoelectric detectors. However, single-cell resolution is still beyond the reach of such sensors, and the underlying sequential acquisition process prevent from imaging at sufficient frame rate. To address this challenge, I will develop new sensors and associated interrogation techniques with 1) high acquisition speed and 2) high sensitivity at high acoustic frequencies, to resolve temporally and spatially the activity of single neurons. This will enable to 3) image n