RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Ecology and evolution of cooperative breeding in the carrion crow - 'corvus corone' - an experimental approach'.

assistant: **Objectives**

Research objectives and content This project focuses on one of the most active field of behavioural ecology, the cooperative breeding in birds. The carrion crow (Corvus corone) is an excellent model to test the most recent hypothesis on cooperative breeding. Comparision between some European well-studied non-cooperative populations and the Spanish cooperative population provides an original intraspecific approach to 'helping' in birds. The aims of proposal are: description of crow cooperative behaviour, search for ecological and demographic correlates of helping, estimate of adaptative benefits for helpers and recipient breeders. The use of DNA fingerprinting tecniques and field experiments are expected to produce innovative results, providing data on some of the most controversal aspects of cooperative breeding (for example, conflict of interest between helpers and breeders), and contributing to the reassessment of theories which is now under way. Training content (objective, benefit and expected impact) The objective of the training is to introduce the candidate to the most modern tecniques applied to behavioural ecology, improving their skills in the application of molecular tecniques, design of field experiments, advanced statistical treatment of data and modelling procedures, making them capable of passing on their scientific knowledge to other Community Research Centers, especially in Spain and Italy. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Optimization of MR-Guided percutaneus breast biopsy and evaluation of its clinical value'.

assistant: **Concept**

Objectives:Contrast-Enhanced MRI of the breast may be the most sensitive method for the detection of invasive carcinoma and is capable of detecting small non-palpable lesions, which are not visible by other modalities. Its usefulness is, however, limited by the facts that only one of 3-4 MR-detected lesions proves to be a carcinoma, after needle localization detection of non-calcified non-palpable early lesions. This is a problem for gynecologists/surgeons. Additionally MR-guided core biopsy is not yet clinically established. The first MR biopsy coils still had significant disadvantages (limited access to lesions close to the chest wall, access to the breast from only one side, limited accuracy, complicated handling). A second generation prototype biopsy coil will be available 7/97, which promises to fulfill all above requirements.Brief description:In this multicenter trial an optimum procedure for MR-guided biopsy should be developed (phase A) and the clinical value of MR-guided biopsy (phase B) shall be tested.Phase A: The procedure needs to be optimized by people with large experience with percutaneous breast biopsy. The development includes development of appropriate software (together with industry, partner 5). Since experience with percutaneous breast biopsy is still limited in Germany, partners from outside Germany with extensive experience (partners 3 and 4) in this field and worldwide accepted leadership for over 10 years are required.Phase B: Based on an optimized technique MR-guided percutaneous core biopsy and preoperative localization will first be tested on small mammographically detected lesions (indication 1). It shall then be applied to lesions that are only or best visualized by MR [MR-detected multicentricity in preoperative patients (indication 2), M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ADVerse outcome Network for non-mutagenic CarcinogEns' under Horizon 2020.

assistant: **Concept**

The field of toxicology is evolving from purely descriptive to a highly data‐rich science. To structure this large amount of data and in this way make the usage more effective for the safety assessors, the concept of adverse outcome pathways was established providing a means of understanding how chemicals induce adverse effects through their toxicity pathways and modes of action. However, there are some doubts if the one initiating event - one adverse outcome relationship enforced on AOPs by the OECD guideline is able to cover more complex adverse effects like hepatocellular carcinoma resulting from non-mutagenic chemical exposure. Therefore, the ADVaNCE project will demonstrate based on the just mentioned example that combining all existing knowledge into an adverse outcome network formed by interlinked AOPs is needed to cover all the pathways and intervention points activated in order to contribute to the development of hepatocellular carcinomas. Computational approaches will be used to extract important key events and their relationships from existing data sources and the relevant literature. These will be compared with existing AOPs and further experimental validation will be started. The computational and experimental result will finally guide the development of an integrated testing strategy completely based on in silico and in vitro data, which development and validation regarding regulatory usage will be continued after the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Graduate school in nonlinear science' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

3 Ph.D. EU-fellowships at the Danish Graduate School in Nonlinear Science are announced. Within the framework of the Marie Curie Training Site program of the EU, the Graduate School in Nonlinear Science invites applications for stays of 6 months from young scientists engaged in a Ph.D. study in this general subject area. Eligible candidates should have a University diploma in science or engineering, and be non-Danish nationals of European Union or of an associated state. The Graduate School in Nonlinear Science is a collaboration between MIDIT at the Technical University of Denmark (DTU) OFD at Ris National Laboratory (Risoe), and CATS at University of Copenhagen (UC). (see: http://www.imm.dtu.dk/undervisning/phdschool/intro.html). The school is sponsored by the Danish Research Agency. In collaboration with industry , this school provides a Ph.D program at the highest international level, with the aim of preparing students to apply recent advances in Noninear Science to outstanding problems of science and technology. The candidate will be involved in state of the art research projects relevant to the subject of their Ph.D study. They will practice the application of multidisciplinary methodologies to fundamental problems of nonlinear science. The recruitment will be carried out on an equal opportunity basis. Information: Prof. P.L. Christiansen, MIDIT, IMM, Technical University of Denmark, Bldg. 305 DK-2800 Lyngby; Phone: +45 45253096, Fax: +45 45931235; e-mail: plc@imm.dtu.dk Application: incl. CV, mark sheet, publication list, and letters of reference should be send to P.L. , Christiansen before October 1, 2001
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fungal natural products for food safety: towards biocontrol of cereal blast diseases by disrupting the novel target septins.' (TargetSep).

assistant: **Innovation**

A consequence of climate change is the emergence of fungal plant diseases in Europe. Blast disease on cereal crops is an economically important plant disease caused by the fungus Pyricularia oryzae and poses a significant threat to global food security. While initially well known as the major disease on rice, wheat blast has recently emerged and is of major concern in wheat production areas since P. oryzae has already developed resistance against most used fungicides. Sustainable solutions for the biocontrol of the cereal blast disease are needed, and active fungal natural products inhibiting novel targets represent a promising alternative.Septin proteins are essential for the pathogenicity of P. oryzae and other fungal plant pathogens and their absence in land plants makes them compelling targets. Yet, no product has been developed to target fungal septins. In a preliminary study, we employed a self-resistance guided genome mining approach to identify candidate biosynthetic pathways of fungal natural products which contain a septin decoy gene. Two biosynthetic pathways were found to likely produce septin-disrupting compounds. I propose to investigate these candidate pathways and validate their potential to control cereal blast. First, wild fungal species containing the identified pathways will be tested for septin-disrupting activity using in vitro fluorescence microscopy-based assay. Second, a synthetic biology approach to activate these candidate pathways in the heterologous host Aspergillus oryzae will aid in characterizing natural compounds and their structure-activity relationships. Finally, natural septin-disrupting compounds will be tested for their ability and efficacy to control blast disease in planta. During TargetSep, I will embark on a multidisciplinary jo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Community Energy for Energy Solidarity' (CEES) targeting Horizon 2020.

assistant: **Abstract**

Energy poverty is getting more and more poignant around Europe. According to the latest pan-European report by the EU Energy Poverty Observatory, 37.4M people were unable to keep warm in 2018, 33.8M had arrears on their utility bills, and 19% of households reported being uncomfortably hot during summer.Despite this issue being mainly addressed from the public policy perspective through measures that range from alleviation using social tariffs to subsidies to household refurbishment or purchasing energy efficient appliances, civil society plays a very significant and growing role. Communities have found different ways of getting together to fight energy poverty. Solidarity is the cornerstone of all these initiatives which have huge potential for replication. Renewable energy cooperatives (RESCOOPs) are the most democratic and oldest form of energy community: groups of citizens that get together in a democratic manner to achieve energy resilience, independence and sustainable energy generation and use.The CEES project identifies and analyses the most successful cases of community energy initiatives to tackle energy poverty in Europe, validates them academically and empirically, supports the overcoming of regulatory and financial barriers, and then creates a toolkit for EU replication through RESCOOPs network of +3000 energy communities, a formula which has proven very successful in the past. CEES will facilitate the adoption of behavioural and energy efficiency measures in households, create financial and non-financial support schemes to address energy poverty and empower community leaders (and organizations working in adjacent areas such as financial advice, health care or even fire and police services) to identify and deal with energy poverty, establishing quick and res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Gene Regulatory Network Architecture in Neuronal Development' (GRAIN) targeting Horizon Europe.

assistant: **Abstract**

Stem cell-based therapy is an attractive way to treat a panel of as-yet incurable diseases, amongst which is Parkinson’s Disease, caused by the progressive degeneration of mesencephalic dopaminergic (mesDA) neurons. To make this a reality, efficient and precise differentiation protocols of human embryonic stem cells (hESCs) need to be developed. While a protocol for differentiation of mesDA neurons exists, little is known about the resulting progenitors’ homogeneity and the mechanisms that control their maintenance, expansion and differentiation. MesDA neurons arise from ventral midbrain progenitors, whose differentiation requires the transcription factor Neurogenin 2 (NGN2). NGN2 acts as a “master regulator” by binding to, and stimulating transcription of, a panel of poorly defined target genes, while itself negatively regulated by HES1, one of the main effectors of Notch signalling. Yet, the involvement of Notch signalling in mesDA differentiation and the composition of the HES1/NGN2 gene regulatory network (GRN), i.e. the group of genes under their transcriptional control, in this context remains largely unknown.The aim of this action is to determine the mechanisms by which HES1, NGN2 and their GRN control mesDA differentiation. Building upon and expanding existing tools and knowledge in the host lab, I will use a multidisciplinary approach combining genome editing and hESC biology to derive mesDA progenitors from a panel of wildtype and HES1/NGN2 KO hESCs cell lines, with a multiomics approach to define the members of the HES1/NGN2 GRN and unravel its mechanism of action. The synergy between the expertise of the host lab in developmental and stem cell biology, and my extensive knowledge of bioinformatics and experience in the generation of multiomics datasets, will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Food scarcity and knowledge making: crops and environments in the 18th-century Portuguese and French Atlantic' under Horizon Europe.

assistant: **Concept**

How to address food scarcity? Scarknow explores the various forms of knowledge mobilised to address scarcity in the Portuguese and French Atlantic in second half of the 18th century. It focuses on two tropical, yet geographically distinct case studies: the French colony of Saint-Domingue, and the northwestern part of the Amazon estuary in Brazil. The question of scarcity was central in 18th-century debates on political economy, a newly founded discipline which had the goal of outlining strategies to produce and increase wealth through the harnessing and transformation of natural resources. Administrators, governors, savants, clergymen, and naturalists all worked to prevent food and crop shortages through grain trade policies and by encouraging the identification of alternative resources in European colonies overseas. But how was the concept of scarcity constructed in ecologies as diverse as Amazonian riverbanks and islands, or the Saint Domingue sugar plantation plains? What kind of knowledge(s) were mobilised to address shortages of dominant crops such as cassava and wheat in non-European geographies? And how were environmental concerns tackled in forms of colonial extractivism and local agricultural practices? This project aims to recover the knowledge and practices—environmental, gendered, hybrid, mechanical and entrepreneurial—developed to address scarcity, along with the actors, European and not, involved in these efforts. It goes beyond a “national Atlantic model”, rather posing transversal questions which underline those hybrid and entangled environmental and knowledge-making dimensions overshadowed by national narratives of empire. The project goes beyond the state of the art by framing the history of scarcity as an Atlantic and environmental history. In doing s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A pilot line for the next generation of smart catheters and implants' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The objective of POSITION-II is to bring innovation in the development and production of smart catheters by the introduction of open technology platforms for miniaturization, AD conversion at the tip, ultra-sound MEMS devices and encapsulation. Open technology platforms will generate the production volume that will enable sustainable innovation.  The availability of open technology platforms will result in new instruments that have a better performance, new sensing and imaging capabilities, while the scale of volume will result in lower manufacturing costs. The production of the “brains”  of these smart catheters will take place in Europe, with many European partners contributing essential technologies. The POSITION-II project will consolidate Europe’s premier position as manufacturer of cath lab infrastructure since these new smart catheters will be seamlessly integrated in the cath lab hardware and software platforms. By combining the different sensing and imaging data a more intuitive cath lab experience will be achieved. Looking forward, POSITION-II prepares the European electronics industry for the next revolution in healthcare, bioelectronics implants. Bioelectronics implants are expected to replace a considerable fraction of traditional medicine by direct stimulation of nerves. The miniaturization and soft encapsulation platforms developed in POSITION-II will be the ideal technology frame work for the manufacturing of these bioelectronics implants. The technology platforms developed in POSITION-II are demonstrated by five challenging product demonstrators covering FRR, IVUS, ICE, EP and cell therapy as well as a bioelectronics implant to treat cluster headache.


**Keywords:** Smart Catheters, Cath Lab, Open platforms, IVUS, FFR, ICE, Implantables
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Citizens Collaboration and Co-Creation in Public Sector Service Provision' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The fundamental idea of COCKPIT is that Web 2.0 social media constitute the emerging and de facto mass collaboration and cooperation platform between citizens themselves, and between citizens and public administrations. Therefore, Web 2.0 social media will have very soon establish themselves as a very effective means for creating, sharing and tracking knowledge about citizens' opinions and wishes on public service delivery. COCKPIT adopts a highly synergetic approach towards the definition of a new governance model for the next-generation public service delivery decision making process by combining the research areas of citizens' opinion mining in the context of Web 2.0, Service Science Management and Engineering in the context of the public sector, and deliberative engagement of citizens for forming informed judgements on public services' delivery. COCKPIT supports the notion of open Public Administrations with which citizens have higher confidence and trust among each other and with the Public Administration, resulting in better governance, lower disputes on services' delivery priority setting, higher degrees of public service adoption, lower public service delivery costs, better service innovation, and citizens loyalty to the public services.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Global change impacts on cyanobacterial bloom toxicity' to be submitted under Horizon Europe.

assistant: **Abstract**

Harmful cyanobacterial blooms produce toxins that are a major threat to water quality and human health. Blooms increase with eutrophication and are expected to be amplified by climate change. Yet, we lack a mechanistic understanding on the toxicity of blooms, and their response to the complex interplay of multiple global change factors. Bloom toxicity is determined by a combination of mechanisms acting at different ecological scales, ranging from cyanobacterial biomass accumulation in the ecosystem, to the dominance of toxic species in the community, contribution of toxic genotypes in the population, and the amounts of toxins in cells. I will develop a fundamental understanding of bloom toxicity by revealing the combined effects of nutrients, elevated pCO2 and warming at each scale, and integrate these responses using a unique combination of ecological theory, technological advances, and methodological innovations. Specifically, I will use first principles to scale from cellular traits, like carbon and nutrient acquisition, cellular toxin synthesis and growth rates, to population and community dynamics. To enable rapid assessment of numerous cyanobacterial traits, I will set-up a high-throughput flow-cytometry pipeline. Also, I will develop a novel lab-on-a-chip experimental platform to allow massive parallel screening of key competitive traits in various phytoplankton species and cyanobacterial genotypes. To scale from these cellular traits to population and community interactions, I will study genotype selection and interspecific resource competition in state-of-the-art chemostats. I will further scale-up to natural communities in the field and in large-scale indoor mesocosms to assess global change impacts on the mechanisms underlying toxicity of (near) real-life blo