RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Research Network on Congenital Toxoplasmosis' (1994-1998).

assistant: **Concept**

- To determine the principal risk factors for toxoplasma infection among pregnant women in different European regions. - To develop the clinical and epidemiological base required and to initiate a multicentre study to determine the risk of vertical transmission of toxoplasma infection and the short and long term clinical consequences for infected children. - To determine the validity and clinical applicability of tests for the diagnosis of congenital infection in the fetus and young infant.Objective 1. We propose to conduct a multicentre, case-control study on risk factors for acquisition infection during pregnancy. A multicentre case-control study is required to allow risk factors in different European regions to be identified and to determine the relative importance of risk factors. The 6 participating centres to date are: Brussels, Copenhagen, Lausanne, Milan, Naples and Oslo. The study is a case control design with affected cases selected as women who seroconvert during pregnancy OR who are found to be toxoplasma IgM positive at the first prenatal test. The same questionnaire is used in all centres translated into the national language. Objective 2. The aim is to establish a European cohort of children born to mothers infected during pregnancy which can be followed longitudinally to provide informative data on: the risk of vertical transmission of infection; the prevalence of short and long term clinical sequelae and associated impairment. The variety of different approaches to congenital toxoplasmosis within Europe can be attributed to the lack of up to date, population-based data which is unbiased by referral patterns and is based on a sufficiently large study population. As a result, decisions about existing programmes are largely based on studies over 30 years a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mitochondrial signaling drives parasite differentiation' (MitoSignal).

assistant: **Innovation**

Mitochondria perform three essential functions: ATP production, metabolite synthesis and cellular signaling. These signals, communicating the bioenergetic and biosynthetic fitness of the organelle to the nucleus, play a powerful role in determining cellular fate. The incorporation of mitochondrial reactive oxygen species (mROS) in cellular signaling is an interesting evolutionary outcome, as excess levels of these potent oxidizers have been implicated in many pathologies. While most research focuses on these outcomes of oxidative stress, much less is known about how mROS drive a range of physiological responses. Furthermore, the available studies are limited to a few traditional model organisms, featuring complex cellular systems with numerous mitochondria at different energetic states. Here, we propose to utilize the unicellular parasites, Trypanosoma brucei and T. congolense, as simplified but elegant models to define mROS-driven cellular differentiation. As these protists undergo programmed development between several distinct life cycle forms, there are striking changes to the structure and physiology of their single mitochondrion that manifest in elevated ROS levels. Importantly, we demonstrated that these ROS molecules are essential for the developmental progression of the parasite. Employing these well-chosen models and combining next-generation biosensors, advanced bioenergetic methods, redox proteomics and a CRISPR/Cas9 genetic screen, we will answer the following fundamental questions: Does mROS drive Trypanosoma cellular differentiation? What molecular processes are responsible for the elevated mROS levels during differentiation? How is the redox signal propagated to the rest of the cell? The proposed research aspires to unravel the fundamental mechanisms und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SMAll RuminanTs breeding for Efficiency and Resilience' (SMARTER).

assistant: **Concept**

SMARTER will develop and deploy innovative strategies to improve Resilience and Efficiency (R&E) related traits in sheep and goats. SMARTER will find these strategies by: i) generating and validating novel R&E related traits at a phenotypic and genetic level ii) improving and developing new genome-based solutions and tools relevant for the data structure and size of small ruminant populations, iii) establishing new breeding and selection strategies for various breeds and environments that consider R&E traits .SMARTER with help from stakeholders chose several key R&E traits including feed efficiency, health (resistance to disease, survival) and welfare. Experimental populations will be used to identify and dissect new predictors of these R&E traits and the trade-off between animal ability to overcome external challenges. SMARTER will estimate the underlying genetic and genomic variability governing these R&E related traits. This variability will be related to performance in different environments including genotype-by-environment interactions (conventional, agro-ecological and organic systems) in commercial populations. The outcome will be accurate genomic predictions for R&E traits in different environments across different breeds and populations. SMARTER will also create a new cooperative European and international initiative that will use genomic selection across countries. This initiative will make selection for R&E traits faster and more efficient. SMARTER will also characterize the phenotype and genome of traditional and underutilized breeds. Finally, SMARTER will propose new breeding strategies that utilise R&E traits and trade-offs and balance economic, social and environmental challenges.The overall impact of the multi-actor SMARTER project will be ready-to-use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project' (2007-2013).

assistant: **Concept**

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors will be studied through a foresight approach to inform a redesign of effective addictions governance. Ownership will be described by an historical study of addiction through the ages, an analysis of public and private stakeholder views, and through image analyses, of professional and citizenship views. A study of how addictions are classified and defined will be followed by estimates of their health, social and economic impact. Determinants of addiction will be investigated through a coordinated and cohesive social, economic and biological analysis of initiation, transition into problem use and transition into and out of dependence. The business of addiction will be analyzed through studies of revenues, profits and participants in legal and illegal trade, the impact of suppliers on addictive substance use and behaviours, and analyses of webs of influence on policy responses. Addictions governance will be studied by describing the views and forces that determine the ways societies steer themselves and by stock taking of present governance practices to old and emerging addictions. Youth as customers will be analyzed through considering the impacts of new technologies on promoting and mitigating use, by studying the interrelations of culture and biology, and by determining features that promote resilience and nudge young people to reduce problematic use. The programme itself will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Plant conditioner enhancing plants' drought resistance based on proline aminoacid' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Drought and extreme heat events cause 25% of crop losses in Europe, and reduce availability of irrigation water for agriculture, leading to severe economic impact on farmer’s income. The low proportion of irrigated agricultural land (only 6.7% of total European cultivated area), and the strict limitations for growing genetically modified crops (e.g. resistant to drought), rest much competitiveness to a sector that is extremely vulnerable to weather conditions.Thus, a clear business opportunity exists in Europe for methods to enhance crop drought resistance, which is indeed favoured by the current shift of plant protection product’s market towards preventive tools for optimizing yield performance (12% annual growth, €2,3 billion by 2021).DRYFIT is a new plant conditioner composed by a natural blend of substances already present in plants, that enhances their resistance to water or combined water-heat stress caused by droughts and extreme high-temperature events.DRYFIT is based on proline aminoacid, which increases the cells' (plant) water retention by 20-30%, so they are not harmed by water deficit. The Salicylic acid, its second ingredient, provides additional protection against other abiotic stresses (salinity, metals), and maximizes the performance of proline.Our product value is not only given by the preventive protection to external stresses, but also by its innocuity, and the easy-to-use foliar application mode that does not require exposing roots to air (as is the case of pesticides), thus minimizing the probability of infection by external disease agents.DRYFIT is the result of the intense R&D activity of StarAgro Deutschland GmbH, a German SME currently commercializing other plant conditioners. By this new product, StarAgro forecasts to achieve between 2019 and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Upward mantle flow from novel seismic observations', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

While downward mantle flow (subduction) is well constrained, a grand challenge in Earth sciences is to understand deep upward flow that cannot be explained by plate tectonics. The aim of UPFLOW is to develop an entirely new seismic imaging approach and to use it to constrain plume-like mantle upwellings at unprecendented resolution. Upward flow is critical for continental growth, for returning volatiles to the atmosphere and for producing Earth's largest melting events. These events coincide with major extinctions, supercontinent breakups and with changes in geodynamo behaviour. Seismology has come far by using travel-time and waveform (phase) information but has mostly ignored the amplitude information. Mantle plumes have just started to be robustly imaged, yet resolution is low and uncertainty quantification is lacking. I developed breakthrough seismic imaging methods based on big amplitude data, showing their strong resolution. With recent computing resources and explosion in datasets, it is now timely to use this unique expertise to lead a step change in observational seismology: rather than relying on pre-defined observables (e.g., travel-times), objective statistical techniques exploring the full richness of the data will be used to design observables that provide optimal constraints on Earth structure. I will lead a new off-shore experiment in the Azores-Madeira-Canary islands region, which is an under-studied natural laboratory comprising significant mantle upwellings that are poorly understood in general. The imaging technique to be developed will be applied to these new data and to existing data (Hawaii, Reunion) to obtain the sharpest ever images of mantle plumes along with their interdisciplinary interpretation. These results will have a major impact far bey
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development and evaluation of Radical Oxygen Species (ROS)-responsive drug delivery systems to prevent and cure inflammatory and hypoxic diseases.' to be submitted under Horizon Europe.

assistant: **Abstract**

The evolving landscape of medical research demands innovative breakthroughs to enhance disease treatments. Smart drug delivery systems (DDS) are at the forefront of these innovations, offering precise drug release while combatting oxidative stress and harmful species. ROSCURE-O2 (Radical Oxygen Species (ROS)-responsive drug delivery systems to prevent and cure inflammatory and hypoxic diseases), is a pioneering proposal focusing on engineering ROS-responsive DDS with anti-inflammatory and anti-hypoxia properties.Inflammation profoundly affects global health, contributing to various skin and wound conditions, including radiation-induced skin injuries (RISI). RISI arises from healthy cells' exposure to ionizing radiation used in cancer radiotherapy, leading to issues ranging from mild skin reactions to severe burns, ulcers, infections, and necrosis, impacting the quality of life for over 95% of radiotherapy patients.ROSCURE-O2 aims to develop innovative treatments for inflammatory conditions by targeting ROS and hypoxia precisely. The hypothesis posits that multifunctional DDS  can (1) scavenge ROS, (2) selectively release anti-inflammatory drugs, and (3) deliver oxygen in ROS-rich environments, thus preventing and curing inflammatory diseases. This triple therapeutic approach seeks to overcome the limitations of conventional treatments.Within ROSCURE-O2 the development of a Smart DDS platform that can synergistically address ROS and hypoxia. This involves polymeric DDS with ROS-responsive properties, provided by sulfur-based chemistries and/or antioxidant crosslinkers and the incorporation of oxygen-releasing and ROS-scavenging nanoparticles, like Cerium Oxide. These nanoparticles can be combined with anti-inflammatory active pharmaceutical ingredients to increase treatm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multiscale Micro-to-Macro Material and Structural Models for Aortic Heart Valves: Native, Porcine and Prosthetic Valves' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Aortic valve (AV) disease expressed by tissue inflammation and calcification is one of the major causes for cardiac related illness and deaths in the world. Calcific stenosis leads to leaflet stiffening and abnormal AV mechanical-structural performance: larger deformation gradients and stresses. Current AV computational models are somewhat qualitative and do not capture the local complex nonlinear tissue and structural behaviors. Nonlinear multiscale (heterogeneous) material and structural (MMS) models have been developed and used in the analysis of many traditional and advanced engineering materials. These MMS modeling approaches can also be used for the analysis of biomaterials and bio-systems. New refined MMS models for the AV tissue will be developed at the microscale that can be integrated for the mechanical analysis of the AV structure at the macroscale. The overall goal is to introduce refined MMS for predictive simulations of native, porcine and a class of prosthetic AVs under in vitro pulsatile flow conditions. The proposed predictive modeling framework will be verified using sophisticated imagery measurements to examine the kinematics and deformations of both normal and stiffened (diseased) porcine AV systems. A major aspect of this proposal is to introduce new heterogeneous material models for the prosthetic and native leaflet tissue to be used in the AV-MMS simulations. The new modeling approach employs collagen fiber network (CFN) discrete multiscale model depicting the actual bundles of collagen fibers embedded in the leaflet. The in-situ elastin and collagen mechanical properties are explicitly recognized and a unit-cell (UC) micromechanical modeling approach is used to back-calculate (inverse problem) their properties from traditional tissue tensile test
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stellar Populations and Dynamics: a comprehensive IMF analysis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The number distribution of stars by mass in a stellar system, at birth, is given by the initial mass function (IMF). The IMF not only regulates the chemical enrichment of a galaxy, but it also determines its spectrum and the mass scale. Moreover, it is the bridge between the physics and properties of individual stars and the light that we observe from distant galaxies. Therefore, the IMF constitutes a fundamental piece in modern Astrophysics. Since the pioneers works suggested an invariant IMF in all star-forming systems, the universality of the IMF has been a common assumption in every extra-galactic study over the last 50 years. However, recent claims of IMF variations in nearby massive galaxies have challenged this standard picture. The Stellar Populations and Dynamical (SPanD) project aims to perform critical study of these IMF variations, by combining both stellar populations and dynamical techniques to derive the IMF in nearby and high-redshift objects. Given the strong dependence of most of the astronomical observables on the IMF, a comprehensive IMF analysis as proposed in SPanD is crucial to better understand our observations, and ultimately, to understand how galaxies have formed and evolved.


**Keywords:** Galaxies:formation Galaxies:evolution Galaxies:stellar populations Galaxies:dynamics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Decoding dynamic chromatin signaling by single-molecule multiplex detection', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Transient multivalent interactions are critical for biological processes such as signaling pathways controlling chromatin function. Chromatin, the nucleoprotein complex organizing the genome, is dynamically regulated by post-translational modifications (PTMs) of the chromatin fiber. Protein effectors interact with combinations of these PTMs through multivalent interactions, deposit novel PTMs, thereby propagate signaling cascades and remodel chromatin structure. To reveal the underlying molecular mechanisms, methods outside classical biochemistry are required, in particular due to the combinational complexity of chromatin PTMs and the transient supramolecular interactions crucial for their recognition. Here, we develop a novel approach, where we synthesize arrays of chemically defined designer chromatin fibers and use dynamic multiplex single-molecule imaging to dissect multivalent signaling processes in chromatin. Our studies target a key pathway, the DNA damage response (DDR), which regulates DNA repair processes central to cell survival and is critically implicated in cancer. Detailed knowledge is of utmost importance to develop targeted therapeutic interventions. We thus employ advanced peptide and protein chemistry to generate libraries of chromatin fibers of a defined PTM state that is encoded in the chromatin DNA. With the library immobilized in a flow cell, we use single-molecule detection to directly observe signaling processes by key DDR effectors in real time. Subsequent in situ polony decoding allows the identification of each chromatin fiber’s modification state, enabling broad sampling of signaling outcomes. Finally, we use dynamic computational models to integrate the effector-chromatin interaction network and test key mechanisms in cancer-based cell cult
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'System level optimisation and control tools for diesel exhaust aftertreatment' (SYLOC-DEXA).

assistant: **Concept**

Envisaged emission standards for passenger car Diesel engines do not allow to optimise the behaviour of individual components of a Diesel engine exhaust system that will become the most import and design issue in future. The objective of this project therefore is to develop a generally applicable user-friendly software toolkit for the computer-aided engineering of complete Diesel engine exhaust systems that meet Euro 4 and beyond emission standards. The simulation tool will be extensively validated via laboratory and engine bench tests. Selected demonstrator cases will show the optimisation potential of the simulator toolkit. The project consists of eight partners from five different European countries with devices and low emission Diesel engines.