RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Human ECM-based platform for anti-cancer drug testing - CARES (CAncer dRug tESting)' to be submitted under Horizon Europe.

assistant: **Abstract**

With 2 million cancer-related deaths and an annual cost of €100 billion, cancer constitutes a major European challenge. Cancertreatments have considerably improved over the last decades, however, the success rate of new anti-cancer drugs in clinical trialsremains frustratingly low, limiting the opportunities for fast and accurate development of innovative targeted cancer therapies. Ourvision is to provide a bold and innovative technology that recapitulates the active part played by the human tumourmicroenvironment, which has crucial roles in regulating tumour initiation, propagation, and progression, through the dynamiccrosstalk between the tumour cells and the extracellular matrix. CARES combines leading academic and non-academic experts in thefields of matrix biology, biomaterials, microfluidics and cancer research to establish an accurate tool to assess cancer cell responses toa variety of anti-cancer drugs. As a proof-of-concept, we will use breast cancer cells as a model system, with the perspective ofextending the system to other cancers. Our final goal is to deliver a novel and user-friendly platform that, by resembling the humantumour microenvironment in early and advanced cancer stages, can predict, with unprecedented accuracy, the response of tumourcells to anti-cancer therapies in vivo. This will facilitate development and testing of new drugs and narrow the gap betweentranslational cancer research and targeted cancer treatment, with a significant impact on society and the economy. The ambitiousscientific goal will provide the background for intense trans-sectoral and interdisciplinary training of young scientists, who will beprovided with an excellent translational research portfolio, allowing them to succeed both in academia and industry.


**Keywords:** Ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CMXsafe: A novel cloud-based secure communication architecture to simplify emerging IoT regulatory compliance' (CMXsafe) under Horizon Europe.

assistant: **Objectives**

Security in Internet-of-Things (IoT) environments has become a major concern. This is partly due to a large number of remotely exploitable IoT vulnerabilities in service authentication and access control combined with the lack of timely technical support. Furthermore, emerging regulations require changes in IoT deployments difficult to apply in a generalisable fashion. This difficults reusability, and scalability, and increases development and management costs. Therefore, the objectives of CMXsafe are twofold: a) Provide a proxy-layer communication architecture devised to offload security communications functions from IoT applications into application-agnostic proxy modules. This simplifies IoT device application designs and the deployment of security updates.b) Devise CMXsafe components abiding by the Security Evaluation Standard for IoT Platforms (SESIP) methodology, accepted by the European Committee for Standardization to facilitate composite cybersecurity certification schemes.To accomplish this, I will describe the technical requirements according to the SESIP standard and implement a testbed comprising 8 IoT devices and the cloud side of CMXsafe architecture.These activities will take place at the University College of Dublin School of Science, at the ASEADOS Lab where I will be supervised by Prof. Anca Delia Jurcut. CMXsafe will allow me to improve my competencies in cybersecurity regulations, cloud architectures and valuable transferable skills required to succeed in the industry.CMXsafe will guarantee a successful two-way transfer of knowledge because CMXsafe combines my background experience in security decoupled communications with the host’s experience in cybersecurity, regulations and business relations with industry partners. Therefore, CMXsafe will contr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Environmentally Friendly Food Packaging Tray with Lower Carbon Footprint' (RPET-FC).

assistant: **Innovation**

RPET-FC will address the specific objectives of capacities research by supporting low to medium technology SMEs in response to an increasingly competitive European and international market. It will achieve this through providing SME food-processing companies a new food packaging tray that will be lighter that the current marker leader. This prototype will facilitate high-speed stacking, packing and safe transportation of a whole range of food products, with significant carbon footprint reduction, environmental impact and cost savings in materials. The new prototype food tray will utilise 25% less material and will be made from 100% recyclable rPET. This project will facilitate greater cooperation between SMEs of different nations, research institutes and other enterprises, improving the SME’s strategic partnerships and networking for innovation. These SMEs currently have limited research capacity; however, this project will enable better access to the knowledge economy, R&D institutes and exploitation of the latest technological advancements. By providing an efficient, ecologically friendly food tray and transportation system based on new state of the art technology that will need to be developed, which will contribute towards state of the art manufacturing, improved space utilisation, lower production and transportation costs, reduction in carbon footprint by the utilisation of recyclable materials.  Issues surrounding loss of state of the art and increasing production costs within the European plastics industry, highlight the need to be increasingly cost effective, as many areas around the globe, including Europe come under increasing pressure due to lack of raw materials or environmental pressures in terms of landfill waste combined with decreasing oil reserves and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Durable Architectural Knowledge', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Along with the paradigm shift that changed the way of architectural drafting from 2D analog plans and scale models over 2D digital plans to complex digital 3D models, the importance for libraries, museums, and archives for long-term preservation of architectural digital 3D models was recognized some years ago. To this end, research projects trying to set up a process to capture, describe, manage, preserve, and make available digital CAD models created by architects during building projects were established in the United States as well as in Europe. Despite the shift from analog to digital representations, the access mechanisms of current long-term archiving systems in the architectural domain are still based on simple metadata schemes inherited from the analog world and therefore limited in the same way as searching with a card index in the analog age. The potential inherent in a full digital representation is not exploited so far as detailed semantic information in the digital documents is either not available or simply not used for retrieval. In the DuraArK project we will develop a long-term preservation system for architectural content that will overcome these shortcomings. It will allow searching and accessing data on different semantic levels going far beyond the possibilities of currently used metadata schemes. At the same time, it will provide secure and future-proof data storage by tackling the problems arising from digital decay.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cavity Enhanced Microarray as an Ultra-sensitive Tool to aid Sepsis Diagnosis' (CE-MICROARRAY).

assistant: **Innovation**

Sepsis is a life-threatening illness caused by the body’s overreaction to an infection and can be triggered either directly by infection or may occur after medical treatment or surgery.The mortality rate in patients admitted to hospital with severe sepsis is 28-50% and it remains the most prevalent cause of death in non-coronary Intensive Care Units (ICUs ). It is estimated that in the US ~$17 billion were spent annually treating sepsis in patients and a similar amount is spent across the EU. To reduce costs and provide better treatment to patients, early, accurate diagnosis is critically important.The CE-microArray project will utilize existing technology from clinical chemistry, microplate readers and cavity enhanced spectroscopy in a truly novel way to develop more sensitive, accurate, faster and more useful diagnostic platform.The project consortium comprises experienced SMEs from across Europe who have developed the concept but do not have the capability to undertake the required Research and Development to produce working prototypes in preparation for commercialization. To do this they require funding to pay third party R&D specialists to undertake the R&D.The project aims to produce a solution based on colorimetric detection that will be up to 100 times more sensitive, reducing the damage to patients with sepsis, allow sensitive and accurate detection of an increased range of biomarkers at lower cost and higher throughput. The market opportunity is estimated be greater than €1 billion and will bring a cumulative profit of ~€38 million to the SME consortium over 5 years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The limits of general relativity'.

assistant: **Innovation**

General relativity, Einstein's celebrated theory, has been very successful as a theory of the gravitational interaction. However, within the course of the last decades several issues have been pointed out as indicating its limitations: the inevitable existence of spacetime singularities and  the fact that it is not a renormalizable theory manifest as shortcomings at very small scales. The inability of the theory to explain the late time accelerated expansion of the universe or the rotational curves of galaxies without the need of unobserved, mysterious forms of matter/energy can be interpreted as shortcomings at large scales. These riddles make gravity by far the most enigmatic of interactions nowadays. Therefore, the understanding of gravity beyond general relativity seems to be more pertinent than ever.We propose to address this difficult issue by considering a synthetic approach towards the understand of the limitations of general relativity and the study of phenomenology which is usually considered to be outsides its realm. The proposed directions include, but are not limited to: the study of quantum gravity candidates and their phenomenology; extensions or modifications of general relativity which may address renormalizability issues or cosmological observations; explorations of fundamental principles of general relativity and the possible violation of such principles; the study of the implications of deviations from Einstein's theory for astrophysics and cosmology and the possible ways to constrain such deviations; and the study of effects within the framework of general relativity which lie at the limit of its validity as a gravity theory. The deeper understanding of each of these issues will provide an important piece to the puzzle. The synthesis of this pieces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structure preserving limited area weather modelling' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

As the climate crisis progresses, and we see an increase in extreme temperatures, the importance of accuracy in regional weather forecasting significantly increases. These regional models, or limited area models (LAMs), run at the highest feasible resolution to well resolve fine grain features in the model. Due to the global nature of the atmosphere, LAMs are coupled to a global forecast model, which due to the larger size must run at a coarser resolution and does not see the fine grain structures. This project will increase the accuracy of this coupling between LAM and global model. Specifically, the core focus is to utilise deep learning to recover accurate fine grain structures from a coarse global model to be incorporated as boundary data to the LAM. The philosophy followed is that if one wants to couple two models it is paramount to preserve the physical structures between the two models. One may think of such structures as conserved quantities here. In addition to utilising this philosophy to optimise the coupling between models in the traditional (deterministic) sense, new technologies in structure preserving deep learning will be developed. These aim to resolve the fine grain features to be qualitatively consistent with a global model ran at high resolution.  This is an interesting problem from a mathematical perspective as it applies expertise from numerical analysis and geometric numerical integration to develop the field of machine learning.This project has been designed to be in line with the UK Met Office atmospheric models and is of high research interest to them.


**Keywords:** Structure preserving deep learning; Limited area modelling; Regional weather forecasting; Geometric numerical integration; Conservative discretisations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dissecting the role of Activin signalling in the acquisition of neuronal subtype identity in the telencephalon of the mammalian embryo' in the context of a Seventh Framework call.

assistant: **Objectives**

Understanding the molecular control of neuronal differentiation is critical for the safe and effective use of embryonic stem cells (ESCs) for regenerative medicine and for generating the correct cell types for disease modelling. A central step in the neural differentiation process is the generation of neurons with different subtype identity. In this project we will address how telencephalic neural progenitors acquire specific neuronal fates using the mouse embryo and mouse ESCs. To achieve this we will dissect the pathways that regulate neural differentiation and in particular, those involved in the acquisition of neuronal identity within the telencephalon. We will focus on Activin signalling, that we have previously shown to control interneuron specification. We will (i) study how Activin signalling controls neuronal fate and differentiation in vivo, (ii) identify the targets of Activin signalling within the developing telencephalon, (iii) develop novel protocols for the differentiation of ESCs into neuronal subtypes that are of interest to regenerative medicine, and (iv) examine how Activin cross-talks with the other main signalling pathways that control neuronal identity in the telencephalon, the Shh and Fgf pathways. Our results will not only shed important light on the molecular mechanisms regulating the acquisition of identity of neuronal subtypes that are affected in a wide variety of neurodegenerative diseases, but will also establish novel protocols for the differentiation of  ESCs into these neuronal subtypes, having in this way a direct impact in regenerative medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Migrant insertion in the informal economy deviant behaviour and the impact on receiving societies' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The role of migrant workers in the growth of the informal economy, the spreading of deviant behaviour among migrants and the shifting of many migrants into the illegal economy, the negative attitudes of receiving societies towards migrants are generally studied one at time and country by country. The research project aims at getting over the usual division among the different approaches and to criticize the common opinion that neglects how immigration has an important mirror effect" for the problems of the receiving societies.It will deal with the following issues. * The integration of migrants in the informal labour market: what competition with domestic workers? - Studies either on local labour markets or informal jobs will show if migrants compete with domestic workers or replace them in the lowest strata of non standard labour demand. Many variables can have an impact on this process both at micro and macro level. As regards migrants, the research will focus on their migratory projects, that can be very different according to country of origin, gender, education, age and receiving society as well. A more comprehensive typology of the contemporary migratory projects will be defined, over the plain opposition between temporary stay and settlement. - The socio-economic features of the receiving countries and the access policies will be taken into account as control variables at macro level. Their changes over time and differences by country will be analysed in order to have a significant frame of reference. - The project will inquire if many migrants really cross the borders between the informal labour market and the illegal economy and which conditions eventually promote this phenomenon. * Deviant behaviour among migrants: from micro-criminality to the illegal economy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Human monoclonal antibodies as tools for malaria research and therapy' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

We will generate human monoclonal antibodies that target Plasmodium falciparum antigens that have been implicated in acquired protective immunity to this parasite, which is the causative agent of the most serious form of malaria in humans.  The main antigenic targets of the protective immunity to P. falciparum malaria as it is developed by people living in areas of stable parasite transmission are expressed on the intact surface of infected erythrocytes or free merozoite stage parasites, and are encoded either by polymorphic single-copy genes or by clonally variant multi-gene families. This has greatly frustrated traditional approaches towards the development of effective vaccines as new prophylactic interventions against malaria.  We will employ a new technology, which was developed by one of us and which allows efficient generation and production of human monoclonal antibodies, to generate tools of unprecedented efficacy in malaria vaccine research. In addition, such human monoclonal antibodies with specificity for targets of protective immunity against malaria hold the promise of new intervention in the form of passive therapeutic immunization. The ambition is to provide 'proof-of-principle' data by developing human monoclonal antibodies with specificity for a representative polymorphic single-copy antigen (PfMSP1) and for specific members of the PfEMP1 antigens encoded by the clonally variant var multi-gene family. Both PfMSP1 and PfEMP1 are strongly implicated in protective immunity to P. falciparum malaria, not least because of research by the applicants. The project goes clearly beyond the current state-of-the-art in malaria research by combining groundbreaking technology with rational, evidence-based selection of candidate parasite antigens as targets of therape