RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unveiling the Molecular Secrets of Reproductive Mood Disorders: a Multi-Omics Approach Project' under Horizon Europe.

assistant: **Concept**

Reproductive mood disorders (RMDs), including premenstrual disorder and postpartum depression, have a significant impact on women and their families, contributing to the well-known gender gap in mental health. However, effectively diagnosing and treating RMDs remains an ongoing challenge. These conditions are closely tied to hormonal changes during menstruation and childbirth, indicating a shared vulnerability. While the precise mechanisms are not yet fully understood, emerging data, including my work, supports the hypothesis that genetic predisposition, chronic inflammation, and metabolic dysfunction play pivotal roles in the development of RMDs. The MoodMAP project aims to discover novel molecular markers for RMDs, provide insights into the biological factors influencing varying vulnerabilities to mood disorders in women, and enhance diagnostic, preventative, and treatment strategies for RMDs. The endeavor leverages three Nordic population-based cohorts a) to DEPICT a comprehensive architecture of RMDs by integrating genomic, inflammatory proteomic, and metabolomic data; b) to TRIANGULATE evidence for identifying biologically functional and causal biomarkers using cell data manipulated with hormones and advanced epidemiologic methods; c) and to PREDICT treatment outcomes, including treatment resistance and subsequent suicidal behavior, through multi-omics data and machine-learning methods. MoodMAP adopts an innovative approach by studying both RMDs together, aiming to uncover the biological basis of female vulnerability to mood disorders through multi-omics data. By integrating advanced omics techniques, hormone-manipulated cell data, and cutting-edge epidemiologic and statistical methods, MoodMAP holds the potential to understand the psychiatric sensitivity associate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fast-Driven Quantum Dot-Based Minimal Kitaev Chains' in the context of a Horizon Europe call.

assistant: **Objectives**

Majorana bound states (MBSs) are exotic quantum states with nonlocal and nonabelian properties, making them a novel phenomenon in condensed matter physics and a promising basis for quantum information technology. A platform based on double quantum dots coupled to a superconductor was developed to address disorder-related challenges in realizing MBSs that plague other set-ups. Proposed by the supervisor, this approach produces poor man's Majorana bound states (PMMs) and is now one of the most promising paths toward realizing MBSs. However, under realistic conditions, PMMs are not fully identical to topological MBSs. The goal of this project is to theoretically investigate the use of Floquet engineering methods—specialized techniques for controlling quantum systems through fast periodic driving—to assess the Majorana character of PMMs in QD-based platforms. By combining the supervisor's expertise in PMMs with the fellow’s background in Floquet engineering, the action aims to achieve breakthroughs in understanding and manipulating these elusive quantum states. Specifically, the project will develop new ways to measure the similarity of PMMs to true topological MBSs. Furthermore, it will establish innovative protocols for performing nonabelian exchange operations, which are essential for proving the exotic properties of PMMs. The project’s success will be supported by collaborations with leading theoretical and experimental research groups. By the project's conclusion, the theory aims to have established a new benchmark for analyzing PMMs in QD-based platforms and lay the groundwork for first experimental demonstrations of nonabelian physics with a potentially large impact for future quantum technologies. The fellow will be taken to a leadership position in the field of top
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design Automation for Smart Factories' under Horizon 2020.

assistant: **Concept**

The manufacturing world is experiencing what many recognize as “the fourth industrial revolution”, characterized by production lines turning into complex cyber-physical systems (CPSs). This transformation offers unprecedented opportunities but brings a series of intellectual and engineering challenges. The DeFacto (Design Automation for Smart Factories) project aims at advancing the field of CPS design and its automation by developing novel modeling paradigms, scalable algorithms, and tools to aid the design of smart manufacturing systems, ultimately fostering their widespread adoption.DeFacto’s methodology reasons about systems using reliable compositional abstractions of system behaviors based on assume-guarantee (A/G) contracts. An A/G contract represents the interface of a component as a pair of assumptions and guarantees. Assumptions are the behaviors that a component expects from the environment; guarantees are the behaviors the component promises in the context of the assumptions. Contracts are mathematical models that provide rigorous composition rules and mechanisms to analyze complex system behaviors, validate the design requirements, and develop system components in a modular and hierarchical way. CPSs challenge the existing notions of “modularity”, “hierarchy”, and “separation of concerns” in electronic design. DeFacto rethinks these notions to enable effective and computationally tractable compositional abstractions for industrial CPSs, by blending techniques from formal methods, simulation, and optimization for virtual prototyping and algorithmic synthesis of control software.DeFacto is a major step for my personal growth and my career as a well-rounded, independent researcher. It allows broadening my horizons with new approaches to CPS design automation a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Emergence of Topological Phases from Electronic Interactions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Topological properties of a quantum state of matter describe global signatures which are invariant under weak local perturbations of the system. Such scenarios constitute a major branch of contemporary condensed matter physics and exhibit remarkable phenomena such as quantized edge channels of a bulk-incompressible phase as well as fractionalized quantum numbers and statistics of quasiparticles. In the TOPOLECTRICS ERC starting grant research plan, we investigate topological quantum phases which result from electronic interactions. The key objective is to provide a rigorous link between bare electronic models and low energy effective models hosting emergent topological quantum phases. This task is approached from two perspectives. First, in a top-down approach, renormalization group schemes are developed and employed for weakly and strongly interacting electrons to derive effective models from realistic bare electronic scenarios. We investigate how Fermi liquids can host topological phases such as Chern insulators, topological insulators, and topological superconductors as well as how Mott phases of frustrated magnets can drive the system into a spin liquid regime. The central goal is to identify the crucial parameters which control the stabilization of such phases and to provide a direct feedback for experimental setups. Second, in a bottom-up approach, entanglement spectrum analysis along with reverse Hamiltonian model building is applied to topologically ordered quantum states such as fractional quantum Hall states, spin liquids, spin chain states, as well as fractional Chern and fractional topological insulators. The aim is to develop effective models hosting such topological quantum states and to reconnect them with bare electronic models as well as to investigate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SPINEFX: A University–Industry Network for the Training of High-quality Multidisciplinary Researchers to Deliver Enterprising, Cost-effective Surgical Solutions for Spinal Disease and Trauma' in the context of a Seventh Framework call.

assistant: **Objectives**

SPINEFX is an integrated ITN comprising academic, industrial and clinical partners that is designed to create exceptionally trained researchers with the key skills to deliver commercially significant, innovative solutions to the challenges posed by spinal disease and trauma, namely vertebral fracture. The significant economic and personal impact of these fractures can be gleaned from the fact that in osteoporosis 1 in 3 women will suffer one. Added to this is the high cost of vertebral fractures due to trauma, which can exceed €1 million per patient. It is only with a multidisciplinary approach, which is a synthesis of key academic and industrial skills, that high quality training can be delivered to researchers to address this economic and individual burden. Early Stage Researchers (ESRs) will be located within internationally renowned academic institutions with state-of-the-art facilities and will be involved in projects organized around key themes which cascade over basic, oriented and applied research in a truly ‘bench to bedside and beyond’ manner. New knowledge generated by the ESRs will be exploited by the Experienced Researchers (ERs) who will be located in three of Europes leading Small-Medium Sized Enterprises in this arena. Here the ERs will strengthen their scientific competencies in a market-driven environment and advance their managerial and knowledge transfer skills. As well as playing a significant role in training-through-research, Industry will also be a central element of the Structured Training. The latter includes Network-Wide Workshops open to the international community, secondments and the co-hosting of the Final Conference in conjunction with the EuroSpine Meeting organized by the Spine Society for Europe. All training will emphasise both comple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MW Fuel Cell micro grid and district heating at King’s Cross' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

ELECTROU will install the first MW fuel cell in Europe fully integrated into a building at the high profile redevelopment at Kings Cross, London. This includes the full use of power & heat generated by the fuel cell within the local building, the site wide heat, power and cooling networks, and extends to water re-use and support of the micro grid.ELECTROU will prove that the multi-MW installation due to operational efficiency and negligible emissions will massively improve local and EU wide carbon emission targets. Designed to be an outdoor installation the plant will be adapted to indoor requirements e.g. space, ventilation, and safe access and egress. Up-scaling more than 3 times the installed capacity compared to current indoor installations is a critical step for large scale deployment within building applications.The use of fuel cells in this critical sector is currently prevented due to the high spatial requirements of multiple smaller modules, high capital cost compared to other technologies, and complexity of integration. ELECTROU will break all of these barriers. The project will demonstrate to key decision makers, investors and financiers that there is a near term route to produce electricity and heat in a highly efficient way by a technology which is commercially viable today.ELECTROU will prove through funding support that multi-MW installations within buildings can make an investment grade return without the need for any form of local or EU subsidy, this is a critical step in making the sector viable. A targeted dissemination campaign will be performed to share all of the results with stakeholders and the general public that promotes the technical, commercial and environmental benefits of this mature but high tech technology. We will develop one valid proce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Local-to-global Expansion and PCPs' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This proposal aims to delve further into the study of Probabilistically Checkable Proofs (PCPs), a cornerstone of modern theoretical computer science, that exhibits some of the most powerful local to global behavior. Any NP proof can be written in a format that is locally testable, meaning that local pieces of the proof imply very rich global structure. This theory is strongly tied to hardness of approximation and has significant applications in cryptography. A major goal is to develop simpler and more efficient PCP constructions, with better parameters, as well as to deepen our understanding of robust encodings with local to global features, such as PCPs. The main methodology of this exploration will be through harnessing the power of the beautiful emerging theory of high-dimensional expansion (HDX). Generalizing the concept of expander graphs to higher dimensions, HDX emerge as an exciting cross-disciplinary theory with roots in group theory, number theory, algebraic topology, combinatorics, and theoretical computer science. The HDX theory is characterized by a local-to-global principle, which allows inferences about the global structure based on local link properties. This principle bears significant potential for areas like property testing and it has already shown its power with the construction of C^3 locally testable codes. As these are very closely connected to PCPs, we seek to harness HDX towards advancing our understanding of more general local-to-global encodings, and potentially paving the way for novel PCP constructions.The research directions outlined in this proposal cover a wide array of goals, including the exploration of the HDX theory, the construction of new PCPs, inapproximability, and the creation of novel error-correcting codes. These directions s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Asymmtric Copper(I) Catalysis in Artificial Metalloenzymes'.

assistant: **Innovation**

The proposal that Cu-CATARMs (Asymmetric Copper(I) Catalysis in Artificial Metalloenzymes) aims to design and develop a proficient artificial metalloenzyme which contains a low oxidation state copper (Cu(I)) center, enabling a series of enantioselective new-to-nature transformations in a protein environment.The Roelfes group has been engaged in creation of LmrR based ARMs for the asymmetric copper-catalyzed new-to-nature reactions. Reliable approaches have been developed by the Roelfes group to efficiently recruited the copper(II) species to the LmrR pore, either introducing metal binding unnatural amino acids through in vivo stop codon suppression or supramolecular assembly via the  stacking interaction between tryptophan moieties and metal complex. Our approach is enabled by reducing the copper(II) center which is chelated by anchoring moiety of LmrR to copper(I) center with mild and efficient reductants in situ (objective 1). This design of copper(I) catalysis in LmrR based artificial metalloenzyme will be exploited to develop the following objectives: Objective 2. Asymmetric conjugate addition of alkynes; Objective 3. Asymmetric intramolecular cyclopropanation; Objective 4. Apart from developing the novel methodologies, we will also devote ourselves to reveal the detailed mechanism, aiming to provide theoretical guidance for future works. Overall, the successful development of Cu-CATARMs project will represent a proficient strategy to apply low oxidation state transition metals in enzyme catalysis. The results of the project will inspire the development of C-C/C-N bond formation reactions through copper(I) catalysis in ARMs and offer new strategy for the organic chemistry and material communities when planning a synthetic route for a specific target.


**Keywords:**
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced fuselage and wing structure based on innovative Al-Li alloys' in the context of a Seventh Framework call.

assistant: **Objectives**

The project aims at the development and demonstration of a metallic solution combining innovative aluminiumalloys of the Al-Cu-Li family and advanced assembling technologies such as Laser Beam Welding and hybridwelding. it will be also investigated the potenzial of innovative split-beam process and will be made a comparison with the laser and hybrid arc-laser processes. Aerostructures, including fuselage and wing stiffened panels, are responsible in average for 50% of total aircraft weight. In order to obtain the required panel properties anda significant weight reduction, the strategy of the project is to combine the most suitable materials with the optimised welding process and an appropriate design. Recently developed low density Al-Cu-Li alloys offer directweight reduction of about 5% and the improved property balance versus conventional alloys allows further weightreduction up to 20% through adapted design. The assembling process is a major field of improvement for the cost effective use of aluminium alloys that will be explored in the project. Laser beam welding had demonstrated in the past to be the best suitable welding technology for flat panel production, especially for fuselage. The main advantages are the very low distortion, the absence of defects and reduced postweld re-work. Hybrid laser welding combines the advantages of laser processes with arc welding resulting in high joint quality and completion rates with increased tolerances to fit up and without compromising joint quality and distortion control.It is expected to be most suitable for wing panels. The objective is to demonstrate the feasibility of this material and process solution and bring it to a TRL of 4. For this purpose, the welding technology parameters will be optimised for Al-Cu-Li material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Evolutionary reconstruction of viral spread in time and space'.

assistant: **Innovation**

To identify the causal mechanisms leading to disease emergence, endemic maintenance and epidemic expansion,epidemiologists would benefit tremendously from a full characterization of pathogen spread in space and time. The extensivesequencing efforts for the ongoing swine-origin H1N1 influenza A epidemic testify that analyses of pathogen genetic data arebecoming increasingly important source of information in epidemiology. The new era of metagenomics promises to harvestsuch data in unprecedented quantities with remarkable rapidity. With the objective to assist in designing effective interventionand prevention strategies, we propose to develop a comprehensive statistical framework for uncovering the spatial andtemporal dynamics of pathogen genomes. To this aim, we will design and extend a series of computationally tractable modelsthat use the rapidly proliferating viral genome data to their full potential, connect molecular evolution to underlying spatialprocesses, and pave the path to rigorous and powerful phylogeographic hypothesis testing approaches. Armed with thesetools, we will investigate how genetic variation within important viral pathogens, such as influenza, rabies and HIV, arises andpersists across a diverse range of hosts and environments.