RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Applied phenomics to identify biomarkers in pigs for new concepts in precision livestock farming' in the context of a Horizon 2020 call.

assistant: **Objectives**

Considerable progress has been made in characterising genomes, allowing comprehensive insights into patterns of genetic diversity in many organisms. However, the question of how genetics and environment interact to influence phenotype still remains challenging. Recent advances in DNA sequencing and phenotyping technologies, in concert with analysis of large datasets have spawned 'phenomics', the use of large scale approaches to study how genetic instructions from a single gene or the whole genome translate into the full set of phenotypic traits of an organism. Phenomics can be used across the full range of biological sciences, from cell culture studies in well-defined laboratory environments to populations of organisms under rapidly changing conditions. Advances in “omics” technologies, are providing the necessary tools to extensively phenotype increasingly large collections of individuals. The application and integration of these technologies in animal science will provide great opportunities to tackle biologically important questions (e.g. how to improve animal welfare, the environmental impact) at a whole new level. Indeed, these information could be used to develop precision livestock farming with the ultimate aim to offer a real-time monitoring and management system, solving in part problems of animal productions in high density populated regions, like Europe.The aim of the current project is to take advantage of the knowledge obtained by the University of Bologna in highly phenotyped pigs to better understand the factors, both genetic and non-genetic, that contribute to its variability. In the project, the use of mass spectrometry-based proteomics and metabolomics, will be the approach employed to provide new insights into the spectrum and structure of phenotypic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Medium Voltage Direct Current Electronic Transformer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

More than a century ago, the invention of alternating current (AC) transformer has made AC the preferred choice over the direct current (DC) technologies. Line AC transformers are bulky but simple and reliable devices, made out of copper and iron, providing voltage adaptation and galvanic isolation in AC power systems. Currently, DC technology is increasing its presence in AC power systems, enabled by progress in semiconductor devices and power electronics based energy conversion. DC power distribution networks can effectively support energy transformation and high penetration of distributed energy resources and energy storage integration (both increasingly being DC by nature) in future energy systems. Despite this shift towards the DC power distribution networks, DC Transformer, offering AC transformer like features (and beyond) does not exist, either conceptually or practically.To enable the next (r)evolution in power systems, the EMPOWER project will develop the DC Transformer, a novel, flexible, highly efficient, compact, and reliable conversion principle for seamless energy routing in high-power DC distribution networks. Through a holistic approach, novel concepts, integration and optimization, we will demonstrate new design paradigms for galvanically-isolated power conversion. Our approach relies on resonant conversion utilizing high-voltage semiconductor devices in combination with high-frequency magnetic materials. We propose a new approach for the DC Transformer, avoiding active power flow control and instead utilizing control effort for the safety and protection. The DC Transformer will unify functions of a power converter and a protection device into a single power electronics system, improving drastically the conversion efficiency, reliability and power dens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PHOtonic tools for Quantitative imaging in tissUeS', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The PHOtonic tools for Quantitative imaging in Cells and tissUeS IDP (PHOQUS) will seed a revolution in the development and application of novel imaging modalities and multimodalities to enable the quantitative investigation of biological processes at multiple size regimes from the molecular and cellular to the tissue and organ level scale , by training graduate Physicists and Biologists for the first time to integrate seamlessly photonics, nanotechnology, advanced spectroscopy and novel spectral regions with the latest advances in imaging and diagnostics technology. The photonics focus on new tools and sources will open up opportunities to investigate the mechanisms and nuclear dynamics that control spindle formation and chromosome separation during mitosis as well as cell migration dynamics and mechanics during early embryonic development and the development of cancer in the gut. This will provide a strong interdisciplinary component to the training programme, linking Dundee’s extensive and world-class expertise in Life Science and pioneering work in the Medical School. The training programme will lead automatically to advances and new knowledge on how to harness these new technologies, and new strategies. PHOQUS is strongly intersectoral, with close involvement of 10 Associated Industrial Partners and 9 Academic distributed over 7 European countries.  Imaging science is key for the success of any fundamental or applied research programme aiming to uncover the complexities of the life at multiple scales and to finding new solutions to diseases and conditions. By developing ESRs as a cohort they will avoid becoming isolated in between physics and biology, developing a true identity as interdisciplinary scientists: essentially ""problem oriented physicists” or ""solutio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Anion Exchange Membrane Electrolysis for Renewable Hydrogen Production on a Wide-Scale'.

assistant: **Innovation**

The overall objective of the ANIONE project is to develop a high-performance, cost-effective and durable anion exchange membrane water electrolysis technology. The approach regards the use of an anion exchange membrane (AEM) and ionomer dispersion in the catalytic layers for hydroxide ion conduction in a system operating mainly with pure water. This system combines the advantages of both proton exchange membrane and liquid electrolyte alkaline technologies allowing the scalable production of low-cost hydrogen from renewable sources. The focus is on developing advanced short side chain Aquivion-based anion exchange polymer membranes comprising a perfluorinated backbone and pendant chains, covalently bonded to the perfluorinated backbone, with quaternary ammonium groups to achieve conductivity and stability comparable to their protonic analogous, and novel nanofibre reinforcements for mechanical stability and reduced gas crossover. Hydrocarbon AEM membranes consisting of either poly(arylene) or poly(olefin) backbone with quaternary ammonium hydroxide groups carried on tethers anchored on the polymeric backbone are developed in parallel. The project aims to validate a 2 kW AEM electrolyser with a hydrogen production rate of about 0.4 Nm3/h (TRL 4). The aim is to contribute to the road-map addressing the achievement of a wide scale decentralised hydrogen production infrastructure with the long-term goal to reach net zero CO2 emissions in EU by 2050. To reach such objectives, innovative reinforced anion exchange membranes will be developed in conjunction with non-critical raw materials (CRMs) high surface area electro-catalysts and membrane-electrode assemblies. Cost-effective stack hardware materials and novel stack designs will contribute to decrease the capital costs of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ZERo-carbon building enabling Adaptive opaque Facade technology' under Horizon Europe.

assistant: **Concept**

Building market demands high indoor environmental quality but is under the pressure of energy price volatility, European policies, targeting a carbon neutral building stock by 2050, and local building regulations. A drastic carbon footprint reduction on the EU building stock is only possible with: (i) a strong reduction of heating and cooling energy demand and (ii) the limitation of the embodied environmental impacts of building materials. We propose a disruptive facade concept, the ZERo-carbon building enabler Adaptive opaque Facade (ZERAF), to get a huge decrease in the operational energy demand, while reducing the environmental impact of new and existing buildings through novel materials. ZERAF concept enables shifting the opaque building façade systems from being static thermal barriers to thermal modulators. The disruptive configurations of opaque façade technology and the use of novel materials (smart Shape Memory Alloys, and new generation bio-based polyurethanes) enable such a dynamic thermal control. Moreover, ZERAF minimizes the number of primary sources (in terms of volume and diversity) and then of the embodied carbon. ZERAF radically reconceptualizes the adaptive opaque facades concept, taking the opportunity of doing high-risk/low-TRL research in an interdisciplinary environment to bring cutting edge novelties from aerospace, biomedicine, nanomaterials, chemistry and IOT to building sector. The objective is to scientifically prove that ZERAF concept can control all heat transfer mechanisms in opaque building façades to a significant level. Prototypes will be manufactured for the first time and their thermal behaviour will be characterized in a dedicated laboratory coupling a calorimeter and a continuous sun simulator. To prove that used materials, fabricat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Biogenesis of Oncogenic MicroRNAs : from the structure of the microRNA processing complexes to the inhibition of the maturation of human oncogenes'.

assistant: **Concept**

Micro-RNAs are a recently identified class of small non-coding RNAs that have been shown to regulate the expression of up to 30% of human genes. The contribution of miRNAs in gene regulation is gaining considerable attention, particularly given the growing links between miRNA mis-function or expression and disease. Certain miRNAs have been demonstrated to display oncogenic-like phenotypic effects and their overexpression is heavily implicated in the development of cancers. MiRNAs mature via a two-step pathway involving two processing complexes: first Drosha-DCGR8 and second Dicer-PACT-TRBP. The two ribonucleases Drosha and Dicer are recruited by multi-domain RNA-binding accessory proteins that interact with specific, but currently unknown, structural features present in immature miRNAs. In this project I propose to perform an ambitious and comprehensive multidisciplinary analysis of biomolecular interaction networks involved in human miRNA biogenesis. An automated molecular biology approach will be employed to rapidly clone, express and screen soluble domains derived from each modular processing protein. I will use the latest fast NMR methods to rapidly assess protein and RNA folds, and protein and RNA interaction sites. These results will define the roles of each biogenesis protein, describe RNA recognition mechanisms and reveal the first atomic resolution picture of miRNA processing complexes. This structural evaluation will form the basis for the design and testing of inhibitors of miRNA biogenesis. Over-expression of oncogenic miRNAs correlates well with cancer. I propose to evaluate the possibility of using anti-sense oligonucleotides to block the regions of the immature miRNA recognized by the biogenesis machinery. The efficacy of these molecules will be explored
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'INNATE IMMUNE SIGNALLING: OPTIMAL MICROFLUIDICS PROTOCOLS, PREDICTION AND CONTROL'.

assistant: **Concept**

My research will use integrative modeling of the interactions of the molecular elements to develop a more complete understanding of dynamic cellular signalling and information processing mechanisms. It will focus on information content of collected biological data, predictive power of developed models and gaining control over studied systems. This will be achieved via mathematically designed experimental protocols executed using microfluidic devices. A system of NF-kB signalling with TNF stimulation will serve as an initial model to develop theoretical and experimental tools. Methodology will be then utilized to better understand principles of LPS-IRF3 signalling.The complexity of biochemical systems causes informative experimentation to be a difficult task and makes mathematical modelling necessary to explain collected data. Unfortunately, selecting an appropriate model is usually problematic. Even measurements of all components of a dynamic biochemical system, do not allow for its reverse-engineering if observed only in a small number of experimental conditions. The only possibility to overcome the selectivity of available data is to perturb a system in a way that reveals desired information. The ability of microfluidics to generate spatial and temporal perturbations in extracellular environments provides a unique tool for execution of carefully designed stimuli.In my research, I will combine methods of experimental design with new possibilities of microfluidic devices in order to increase the predictive power of biochemical dynamical models and gain control over studied systems in vitro. The ability to control biological systems is essential to guide drug target selection and design new effective therapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative diagnostic approaches for biomarkers in Parkinson disease' under Sixth Framework.

assistant: **Concept**

Parkinson disease (PD), a specific type of a group of neurodegenerative disorders called synucleinopathies, is the second most common neurodegenerative disorder worldwide. Many neurodegenerative disorders are preceded by a pre-symptomatic phase, probably lasting years, during which degeneration and death of neurons occurs before any clinical symptoms appear. One major goal of clinical research is to improve early detection of these diseases by developing tools to move diagnosis backward in the neurodegeneration temporal course. Thus, the central objective of this INDABIP proposal is the identification of molecular markers that hallmark the onset of a cellular dysfunction in the brain areas involved in PD. These markers would enable to identify at-risk groups both for disease onset and progression during the pre-clinical period. INDABIP combines in a very unique form the latest technologies in biomarkers research provided by the companies to be applied on invaluable human material in one of the largest brain tissue collection ever approached combined finally with further research and validation on cell and in vivo models. Within our consortium we will have access to more than 120 neuropathologically-confirmed brains in Barcelona, Munich and from Brain-Net Germany. The putative biomarkers will be analyzed boinformatically and the more promising ones submitted to a validation program including quantitative PCR, WB and inmunohistochemistry confirmation. Additionally, a careful assessment for the potential as pharmacological targets will be done on the obtained biomarkers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Linked User-driven Multidisciplinary Exploration Network' (LUMEN) targeting Horizon Europe.

assistant: **Abstract**

The LUMEN project is a groundbreaking initiative aimed at revolutionizing cross-domain collaboration and discovery processes in the fields of Mathematics (Maths), Social Sciences and Humanities (SSH), Earth System (ES), and Molecular Dynamics (MD), and beyond. Leveraging the successful GoTriple platform, renowned for its service to the SSH community, LUMEN seeks to extend its functionality to foster interoperability across scientific domains. Through interdisciplinary solutions spanning all four domains, LUMEN will redefine the process of discovery with radical innovations, simplifying initial research phases and facilitating access to advanced AI-powered tools for researchers. By expanding existing discovery platforms in the SSH and Maths domains and developing new platforms for other domains, LUMEN aims to fundamentally transform EOSC services, promoting innovative and customizable solutions for data discovery, attracting new users, and fostering Open Science principles. The project will also drive multidisciplinary cooperation through collaborative platforms and onboard new scientific communities into EOSC, providing them with the necessary tools. Ultimately, LUMEN seeks to revolutionize how research outputs are created, shared, and utilized across scientific domains, enhancing scientific discoveries, fostering interdisciplinary collaboration, and promoting innovation and trust in European scientific research.


**Keywords:** Discovery Services; AI; Chatbot; GoTriple; EOSC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Microtechnology and integrated microsystems to investigate neuronal networks across scales' in the context of a Horizon 2020 call.

assistant: **Objectives**

To advance knowledge in electrophysiology and information processing of neuronal networks, we propose employing microtechnology and microelectronics to rigorously study neural networks in vitro across scales. Across scales pertains to the spatial domain - from details of subcellular components through single neurons to entire networks - and the temporal domain - from single action potentials to long-term developmental processes. Besides our CMOS-microelectronics-based high-density microelectrode arrays for recording and stimulation, the methodology will encompass patch-clamping directly on the microelectrode chips, high-resolution microscopy, genetic methods, large-scale data handling strategies, and dedicated data analysis and modeling algorithms. We will use mammalian cortical neuron cultures and brain slices.We will potentially have access to every neuron and every action potential. We aim at studying - at the same time in the same preparation - details of specific neurons and subcellular components (somas, axons, synapses, dendrites) in their functional context and the characteristics of the corresponding networks (functional connectivity, emergent properties, plasticity). We will study alterations of components and networks over time and upon defined perturbations and mutual interdependence of network and component characteristics.The high-spatio-temporal-resolution methodology will enable new fundamental neuroscientific insights through, e.g., facilitating investigation of axonal and axonal initial segment signaling characteristics, with the “axonal” side of neuronal activity being largely inaccessible to established methods. It will also enable the mapping of the overall synaptic input to a specific neuron, or the high-throughput monitoring of all action potentia