RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chicken image : improvement of chicken immunity and resistance to disease based upon analysis of gene expression' (1998-2002).

assistant: **Concept**

The chicken is the most important source of animal proteins of humans. The poultry indoor- story is facing increasing problems due to the emergence of more virulent forms of path- ovens causing much diseases and mortality in commercial flocks. Moreover, modifications in poultry feeding have currently disastrous repercussions. Therefore amelioration of the quality of food and derivative products will be a major challenge of the next century and one of the most urgent requirements of European citizens. This project aims to create a new generation of tools for avian immunology in the EU, by building a data base of expression profiles for a large set of chicken genes expressed in various types of imp- mane tissues, at different stages of diseases development, and with significant function in regulation of both innate and adaptive arms of the immune system. These resources will be unique and will represent a comprehensive knowledge base of great importance. It will contribute to decrease the losses in flocks through mortality and reduced product quail- tee due to diseases, by increasing the understanding of the molecular mechanisms of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Efficiency and Safety in Geothermal Operations' (EASYGO).

assistant: **Innovation**

How to operate a geothermal system in the most efficient and safe manner? This is the most important and urgent question after a geothermal resource has been identified. EASYGO will answer that question from different perspectives and give high-level training for geothermal operations. The EASYGO programme connects academia, industry and real-scale research facilities to train tomorrow’s leading geothermal-energy experts. These future experts will improve the design and layout of geothermal systems and handle daily challenges during operations. Geothermal energy will play a key role in the energy transition as part of mitigating climate change. Policy makers demand solutions for a sustainable future energy supply. Tackling the challenges of sustainable geothermal operations requires an interdisciplinary and intersectoral approach. Integrating geoscientific and engineering drives technology innovation that will be tested at operational sites. EASYGO combines various research projects from these fields under in situ conditions, using large-scale infrastructure available to all researchers. To achieve the main objective, we will work on the whole chain of geothermal operations, from production to power-plant engineering to injection. We will develop novel monitoring concepts, perform real-time simulations, develop system components, assess novel concepts for operations and test operational parameters at the field scale. Our ESRs will work on a specifically identified project but will learn aspects of the entire geothermal operation chain in an outstanding training programme. The mobility plan of EASYGO envisages each ESR will have at least one academic secondment and one industrial secondment. The outstanding training programme is complementary to the excellent research pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Proton, electron And Neutron sources for non-destructive Testing ANd Investigations and treatment of materials' under Horizon Europe.

assistant: **Concept**

The main goal of the PANTANI project is to complete the design of an innovative laser-driven radiation source suitable for applications in materials science, inspection and treatment, as well as the development of some of its key components. Accelerators are exploited to produce particles and radiation needed for applications of high industrial and social relevance, like analysis of objects of historical, artistic and environmental interest, sterilisation of medical instrumentation, inspection of cargos and goods. Large-scale diffusion of these applications is prevented by the intrinsic limits of the available particle sources in terms of costs, dimensions and flexibility. In this frame, laser-driven particle sources represent an appealing solution to overcome these limitations. They are potentially cheaper and more compact compared to conventional accelerators. Moreover, they can provide several kinds of particles to perform multiple applications with the same source. These novel sources are subject to active research, but no industrial applications are currently available. Starting from the results obtained with the ERC CoG ENSURE and ERC PoC INTER projects, PANTANI aims to address key aspects, never considered before, to develop a laser-driven particle source dedicated for the applications: 1) the development of an application-oriented design of the entire acceleration system; 2) the identification of commercial laser solutions compatible with the source requirements; 3) the production and test of a prototype radiation detector; 4) radiation protection assessment of the designed system, also from the legislative point of view. All these results achieved by exploiting the expertise from both academy (Politecnico di Milano, Host Institution) and industry (the RayLAB an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Overcoming the Selectivity Challenge in Chemistry and Chemical Biology via Innovative Tethering Strategies' (SeleCHEM).

assistant: **Innovation**

In the last two centuries, synthetic organic chemistry has undergone an unprecedented revolution. The ability to understand and modify the molecular structure of matter has changed our life in many areas, such as medicine, agriculture or commodity materials. These major successes gave the impression that synthetic chemistry is a mature field. However, this impression is completely misleading, as current synthetic methods still lack the selectivity needed for the modification of complex molecules. Both selecting between different reactive groups and functionalizing inert bonds in their presence represent formidable challenges. In this project, we propose to develop highly selective “molecular tethers” for the functionalization of both natural/synthetic organic compounds and biomolecules. The envisioned tethers are bifunctional small organic molecules having three fundamental properties:1) A “biting end” with unique reactivity to be selectively installed in situ onto naturally occurring thiols, alcohols and amines. We will use tethers based on acetals and hypervalent iodine reagents.2) A “functional end”, whose reactivity can be revealed “at will” to functionalize bonds that cannot be accessed with the current state of the art of synthetic chemistry, especially inert C-H and C=C bonds.3) Being traceless, meaning that they can be removed easily once the desired functionalization has been achieved.The main impact of this project will be in fundamental synthetic organic chemistry, as it will contribute to overcoming major selectivity hurdles in the functionalization of complex molecules. It will therefore result in faster progress in all the fields depending on synthetic molecules, such as medicine, agriculture or materials. A more efficient functionalization of biomolecules
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'In vivo molecular genetic analysis of DLRIG-1, a novel putative modulator of EGFR signalling in the nervous system of D. melanogaster' (DLRIG-1) targeting Sixth Framework.

assistant: **Abstract**

This proposal involves the molecular characterisation of DLRIG-1, the fruitfly homolog of a novel tumour suppressor gene. With its unparalleled genetic tools the fruitfly, D. melanogaster, provides a powerful experimental system to unravel the function of t his novel cancer gene in vivo.Indeed, a large number of molecular pathways implicated in human tumour biology, have conserved homologs in the fruitfly. DLRIG-1 encodes a novel protein with leucine rich repeats and immunoglobulin domains. During my training years at the Howard Hughes Medical Institute (USA) I generated preliminary data and experimental reagents, which I will now apply to this project.I will address the following specific questions: first, what are the phenotypic effects of mutations of DLRI G-1 in the fly? Secondly, how does DLRIG-1 interact with EGFR (epithelial growth factor receptor) signalling in the fly and what is the molecular mechanism? I anticipate that the results of this project will provide mechanistic insight required for the design of translational research projects aimed at improving treatments of brain tumours (e.g. glioma) that are caused by disregulated EGFR signalling.With its focus on Drosophila neurobiology and morphology the newly established Laboratory of Developmental Genetics at V.I.B. provides a well-suited environment for my research. My return to Leuven as a fruitfly geneticist will add momentum to its emerging Drosophila research community. Through my medical background I will also be well positioned to foster collaborations between the Drosophila research community and the many translational biomedical researchers at Leuven and elsewhere in Europe.In addition, as scientist at V.I.B., I will gain additional expertise in nervous system morphology and strengthen my leadershi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pathogen-responsive hydrogels release antimicrobial vesicles for local infection treatment' under Horizon 2020.

assistant: **Concept**

The rise of bacterial resistance against antibiotic drugs is becoming the leading cause for morbidity and mortality worldwide. In Europe alone, up to 33,000 people die each year from infections with resistant bacteria. Current antibiotic therapy often suffers from low selectivity, adverse side effects in other organs and impaired ability to overcome bacterial barriers. These problems limit the efficacy of our antibiotic arsenal. Local and effective eradication of bacterial infections is of utmost importance to avert the formation of new resistances.My research centres on naturally derived vesicles. All living cells and microorganisms produce these nanoparticles and equip them with unique features for transport and targeted delivery of molecules. I have previously discovered a new group of bacteria-derived vesicles with low cytotoxicity and inherent antibiotic activity. Upon contact with culture supernatant from pathogens, bacteria produce higher potent antimicrobial vesicles. Now, I would like to incorporate these vesicles into hydrogels – Gels4Bac – that respond to pathogenic factors in the infection environment. Once the hydrogel encounters these factors, antimicrobial vesicles are selectively and locally released in the presence of specific pathogens. The local application reduces time until treatment, adverse side effects and unspecific killing of beneficial microbiota.Gels4Bac will create new options for selectively treating infectious dispositions. Stimulation of vesicle producing bacteria with pathogen-derived components may open an on-demand customisable, quick and cost-effective approach for treatment. In addition, it creates new avenues for the discovery of novel antimicrobial agents besides current screening and medicinal chemistry. Such platform technology i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'COFUNDing of the CERN Fellowship Programme 2014' (COFUND-FP-CERN-2014) under Horizon 2020.

assistant: **Objectives**

AbstractFor many years, CERN has operated a trans-national Fellowship programme, offering scientists and engineers challenging opportunities in particle physics research, and in related fields of physics and technology. CERN secured COFUND grants in 2008, 2010, 2011 and 2012. They offer CERN a timely opportunity to enhance the mobility element of this programme without nationality limitations. The 2014 Call comes at the end of the Large Hadron Collider’s first long shutdown which once more makes CERN one of the most exciting places to work for the global physics and technology community.Applicants will propose their own research projects. Selection will be based on the scientific potential of the proposal, and on the demonstrated excellence of the candidate. Working on frontier research and technology projects and profiting from the unique facilities available at CERN, the co-funded Fellows will deepen their knowledge in their own field and acquire international visibility and reputation. They will broaden their skills using the numerous training opportunities and through their exposure to an interdisciplinary and multi-national environment. Inter-sectoral skills will be fostered through CERN’s industrial collaborations and technology transfer projects. Attractive and competitive employment conditions are maintained by guaranteeing three-year appointments rather than the standard two-year terms of CERN Fellows. At least two of these three years will be spent at CERN. We consider this provision to be justified by the size of the Laboratory, the diversity of the research and training opportunities, and by the uniqueness of CERN’s facilities. However, mobility will be enhanced through the opportunity to spend up to one third of the Fellowship in external institutions, incl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Software process amelioration now!' (SPAN).

assistant: **Innovation**

Real problems encountered in the currently applied development methodology, better quality of the delivered software and the emerging need for ISO 9001 standardisation are the major firing elements of this experiment.The formalization of the software development methodology is expected to let the company solve some of the problems encountered so far, like reduced quality of the produced software, poor estimation of forthcoming projects and difficulties in new versions and support of existing products..This formalization, consisting of the definition of a complete lifecycle model, description of the format of deliverables of each phase and the use of the software tools used to support the model, along with the use of object oriented techniques for the analysis and the design phase of the development, are the tangible objectives of this project.THE EXPERIMENTThe definition and application of a software lifecycle model, based on object orientation, in the current context of the company's activities. Appropriate documentation forms will be generated, software development tools will be used and sufficient training will be provided, so as to deliver a well defined procedure for the development process.The proposed model will be checked against a baseline project, is expected to deliver applausive results and be appropriately documented and disseminated, so as to be used as the core methodology inside the co-ordinating and other, with similar characteristics, companies.EXPECTED IMPACT AND EXPERIENCEThe first target is the improvement of the quality of the delivered software. Restricted control on the development process is essential to guarantee that quality.Apart from that, the metrics collection process is expected to provide better insight both on the cost of the process, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Eavesdropping on bacterial gossip in biofilms for resource recovery from wastewater' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

BIORESCue delves into the role of bacterial quorum sensing, a cell-to-cell communication in wastewater biofilms. The hypothesis posits that quorum sensing holds a key role to understanding biofilm formation, and that introducing exogenous quorum sensing signaling molecules in high-rate activated sludge biofilms has the potential to enhance biopolymer production and bioflocculation. As the global water community increasingly recognizes the untapped potential of wastewater as a resource for green energy and biopolymer, this project aims to address a significant knowledge gap in the field. I will develop advanced bioanalytical techniques combining bioassays with chemical screening to explore uncharted diversity, concentration, and activity of signaling molecules in wastewater biofilms. I will explore the dose-effect relationship of signaling molecules in high-rate activated sludge, to offer practical strategies for optimizing resource recovery. By combining this unique dataset with a detailed analysis of bioflocculation and biopolymer composition, I seek to uncover valuable insights on the role and effects of quorum sensing in biofilms. Implemented at the Aarhus University and the host research group, this project will allow me to enhance scientific, communication and project management skills, through a well-designed training program (courses, workshops, regular meeting with supervisors), as well as measures for knowledge exchange and dissemination. Aligned with UN Sustainable Development Goals, particularly in the interests of clean water, affordable energy, and sustainable industries, this project has the potential to revolutionize wastewater treatment, transforming treatment plants into net energy producers and fostering sustainable resource recovery, thus addressing p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Deciphering the unconventional receptor binding and modulation activity of bat influenza A viruses', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Influenza A viruses (IAVs) are zoonotic pathogens that frequently cross the species barrier into humans, often causing severe morbidity and even global pandemics. This cross-species transmission is facilitated in large part by alterations in the interaction between the viral surface proteins hemagglutinin (HA) and neuraminidase (NA) and sialic acid, a ubiquitous glycan that serves as the cellular entry receptor. Although avian hosts have generally been thought to be the primary reservoir for all influenza A viruses, this dogma has recently been challenged by the identification of two novel IAV subtypes in bats, H17N10 and H18N11.Despite an otherwise high degree of functional homology to conventional IAVs, the surface proteins of bat IAVs demonstrate several unprecedented characteristics. Specifically, these proteins are unable to interact with sialic acid; rather, we recently showed that bat IAVs use the major histocompatibility complex class II (MHC-II) protein to gain entry into host cells. Unexpectedly, we observed that N11 downregulates surface expression of MHC-II, suggesting that it potentially harbors a receptor-destroying function. Most surprisingly, bat IAV could replicate to even higher titers the absence of functional NA, a capability which has never been observed among influenza viruses.These findings suggest that the surface glycoproteins of bat IAV may possess a structural plasticity that is much broader than that of conventional IAV. In light of the critical importance of the surface proteins for cross-species transmission of IAV, the goal of this project will be to probe this plasticity, first by determining the mode of interaction between H17/H18 and MHC-II and elucidating the mechanism of N10/N11-dependent downregulation of MHC-II, but most importantly