RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Characterisation of single molecule dynamics within HIV-1 reservoirs as a target for interference with virus persistence and immune evasion'.

assistant: **Objectives**

Human Immunodeficiency Virus type 1 (HIV-1) remains a significant cause of comorbidity and mortality around the world. One of HIV-1 persistence and immune evasion mechanisms is the ability to create hidden virus reservoirs in cells. These virus reservoirs, termed Virus-Containing Compartments (VCCs) are inaccessible to the immune system and help to spread the infection to different parts of the body. VCCs are unaffected by current HIV-1 therapies, and thus remain a major obstacle in the development of successful HIV-1 cure strategies. This project will take a novel approach to the interference with this mechanism of HIV-1 persistence by characterising and exploiting unique molecular dynamics inside VCCs in dendritic cells. Cutting edge super-resolution microscopy techniques enable the study of single molecule behaviour and have already been employed to investigate the minute details of virus-cell interactions during HIV-1 assembly, entry and cell-to-cell spread. These interactions were shown to depend on a specific arrangement and mobility of virus and cell molecules suggesting that efficient virus sequestration and release from VCCs may also require a specific distribution and dynamics of interacting lipids and proteins. Specifically, the “HIV VCC Interference” project aims to: 1) characterise the distribution and dynamics of lipids and proteins in VCCs as a whole and at the sites of virus-cell interactions using super-resolution microscopy; 2) assess the unique characteristics of these sites as targets for interference with HIV-1 persistence and to explore the potential of these targets by testing drugs that perturb specific aspects of cell membranes. These studies, which are aligned with objectives of MSCA-IF, will lead to the description of novel single molecule det
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Statistical Learning for Dynamical Systems'.

assistant: **Objectives**

The proposed research aims to establish groundbreaking new computational methods for the analysis of deterministic, control and random dynamical systems by using tools from the field of Statistical Learning Theory (a.k.a. Machine Learning). These three related system types constitute a very active research area with a wide range of applications, including climate studies, power systems, autonomous vehicle control, aircraft control, robotics, finance and chemical engineering. In many applications the understanding of such systems requires the availability of efficient, high-performance algorithms and a key innovative aspect of this proposal is the development of a unified theory for computational dynamics that has the potential to establish a new field at the intersection of machine learning and dynamical systems theory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A neW concept of pubLic administration based on citizen co-created mobile urban services', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The WeLive project is devised to transform the current e-government approach by facilitating a more open model of design, production and delivery of public services leveraging on the collaboration between public administrations (PAs), citizens and entrepreneurs. WeLive applies the quadruple-helix approach based on the joint collaboration of 3 PAs, 4 research agents and 5 companies, constituing the consortium, plus citizens to deliver next generation personalised user-centric public services. WeLive aims to bridge the gap between innovation and adoption (i.e. take-up) of open government services. For that, it contributes with the WeLive Framework, an ICT infrastructure which adapts, enhances, extends and integrates Open Innovation, Open Data and Open Services components selected from consortium partners’ previous projects. An Open Innovation Area is proposed where stakeholders collaborate in the ideation, creation, funding and deployment of new services. A Visual Composer will enable non-ICT users to assemble public service apps from existing blocks. Stakeholders will upload/sell and download/purchase the generated apps to/from the WeLive Marketplace, thus impulsing economic activity around public services. Personalization and analytics of public services will be done through collaboration of the Citizen Data Vault, which manages personal information, with the Decision Engine, which matchmakes user preferences, profile and context against available public services. Two-phase pilots will be conducted in 3 cities (Bilbao, Novi Sad and Trento) and 1 region (Helsinki- Uusimaa) across Europe. Further, the business feasibility and commercial potential of the WeLive Framework, including its individual assets, will be validated by developing and deploying sustainable business mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Climate tectonics interactions using big data-informed models' in the context of a Horizon Europe call.

assistant: **Objectives**

Earth topography and its subsurface are the result of complex interactions between tectonics and climate. Sediments in the shallow subsurface contain vital resources including water and energy that are crucial for mankind. They also provide temporary and longterm waste and energy storage. At the same time active deformation and rapid climate change interact posing significant risk for natural hazards such as debris flow, hillslope instabilities, and active faulting. The objective of the INITIATE doctoral network is (1) to fill key knowledge gaps how climate tectonics interactions on a wide range of spatial and temporal scales control distribution of sediments, landscape stability, and geohazards using big-data informed models, and (2) to improve urgently needed training in linking large data sets to deterministic forward models and machine learning. The training of a pool of DCs provides an excellent capacity building for the next generation of geoscientists. Combined training in large data, modelling, and entrepreneurial skills will prepare the DCs to create their own start-up business at the end of the project and / or be employed in industry or academia.


**Keywords:** Modelling, large data, climate, tectonics, surface processes, geohazards, sedimentary basins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Risk and Resilience in Developmental Diversity and Mental Health' to be submitted under Horizon Europe.

assistant: **Abstract**

Individuals with mental health (MH) conditions and their families, especially those with highly prevalent neurodevelopmental disorders (NDDs), are exposed to high levels of discrimination and stigma, which significantly affects their physical and mental well-being. Our world-leading collaborative group at the forefront of research in NDDs will launch a new project - ?Risk, Resilience and Developmental Diversity in Mental Health? (R2D2-MH). We propose a double paradigm shift to improve the wellbeing of people with MH conditions and their families. We will move (i) from risk-focused studies towards understanding and promoting resilience, and (ii) from a diagnosis-based approach to a developmental diversity approach that will define wellbeing and functioning across the human lifespan. R2D2-MH aims to identify genetic and environmental protective/resilience factors and how they influence developmental diversity and MH. We will investigate at multiple levels two highly prevalent early risks for MH conditions: prematurity and genetic liability for NDDs. Our project has four main ambitions 1. Provide the largest European multi-scale dataset on early human brain development and MH outcomes; 2 Identify biological mechanisms of resilience to the adverse effects of NDD; 3. Co-develop, with the stakeholders, new digital tools to increase participatory research/medicine and reduce stigma; 4. Establish predictive models to guide personalised interventions. R2D2-MH integrates interdisciplinary and complementary expertise across Europe, Israel, and Australia that covers ethics, epidemiology, sociology, genetics, cell biology, neuroscience, computational modelling, Information Technology, psychology, and psychiatry. Our research is highly engaged: it embeds participant and patient invol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Knowledge and Learning Integration Dynamic Open (KaLeIDO) Systems: a novel knowledge synthesis framework for globally informed and adaptive healthcare' in the context of a Horizon Europe call.

assistant: **Objectives**

Network meta-analysis is an extension of pairwise meta-analysis and is considered the highest possible level of clinical evidence. However, the increasing complexity and the evolving nature of recent public health questions impose new challenges that cannot be addressed by existing evidence synthesis approaches, such as complexity of new interventions, environmental and socio-political changes, or new technologies and misinformation. Thus, there is an urgent need for developing a new knowledge synthesis framework that would enable considering jointly the totality of evidence on an entire domain and would account for all important factors affecting individualized recommendations and global health policies. The aim of the proposed research program is to conceptualize, develop, and establish the “Knowledge and Learning Integration Dynamic Open (KaLeIDO) System” framework to provide a paradigm shift in comparative effectiveness research. The KaLeIDO-CARE program will develop new statistical methods for a) combining information across multiple subpopulations, b) dismantling the complexity of different healthcare strategies, and c) tailoring clinical recommendations to individuals’ characteristics and preferences. The new framework will be publicly accessible to be applied across all health domains while accounting for rapidly changing variables. By implementing artificial intelligence tools, I will facilitate communication of the findings, and will promote transparency, open science, and research collaboration. The new framework will be evaluated and established through a proof-of-concept application that will produce comprehensive recommendations for the management of hypertension for every individual. My international recognition as a leader in evidence synthesis with a tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improving outcoMes and imPact from scenArio based licensing: Classical_Crisis and Co-creaTed IP' in the context of a Horizon Europe call.

assistant: **Objectives**

IMPAC3T-IP is an ambitious coordination and support action that aims to develop, pilot and support the sustainable adoption of a scenario based licensing tool-box through a certified user and trainer programme, for efficient IP licensing for market uptake and societal value creation. IMPAC3T-IP aims to identify current gaps and shortcoming in available licensing tools for 3 main scenarios, stakeholders, IP assets and licensing outcomes; investigate new and emerging technology trends to support licensing and evaluate the feasibility of incorporating them into the tool-box either now or in the future; develop, test, pilot and refine the tool-box through stakeholder engagement and launch, disseminate and sustain the toolbox through a sustainable accredited and certified ‘user’ and ‘trainer’ training programme (IMPAC3T-IP Academy).These objectives are pertinent to the Destination of the HORIZON-CL4-2023-HUMAN-01-31 work program to deliver a human-centred and ethical development of digital and industrial technologies, particularly by enabling a wider range of desired licensing outcomes alongside pure economic benefit e.g. impact, and socially responsible licensing, as well as by systematically expanding the range of IP assets to be supported for licensing beyond the traditional industrial rights for inventions (patents and trademarks), into more modern bundles of rights needed to license digital technologies, including IoT, AI and ML and mobile technologies e.g. data sharing and standards essential patents (SEP). The objectives are also pertinent to the work-programme KSO of creating a more resilient, inclusive and democratic European society, prepared and responsive to threats and disasters, addressing inequalities and providing high-quality health care, and empowering all
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Technology and infrastructures policy in the knowledge-based economy' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This proposal is constructed on the assumption that the move towards an increasing codification and formalization of the knowledge stock of society will critically affect the competitiveness, the growth and the cohesion of the EU. The modifications in the production, the acquisition and the distribution of knowledge will influence directly the process of innovation. In particular, it will have a strong impact on employment. The proposed study will be carried out, at both theoretical and empirical levels, along the three following subprojects: - Empirical studies on the general codification trends in Europe: A clear objective of this project is to go as far as possible in mapping the various qualitative features of the knowledge-based economy with available indicators. A general problem in this field is that many of the objects of analysis which we are interested in - knowledge creation and distribution, innovation activity or capability, knowledge systems, etc... - are intangible activities that are difficult to define. They are certainly not measurable in terms of what we normally think of as statistical variables and creative use of existing indicators will be required - Studies on the institutional responses to the opportunities and challenges to codification in the EU: In order to move from such an analysis to an assessment of policy options it is necessary to grasp how the tendency toward codification affects the innovation process as a whole. It is now generally recognized that the innovation process is interactive and cumulative, involving a complex interplay between the creation and use of scientific knowledge, technology and skills learned in a process of doing, using and interacting. The efficiency of this complex process relies to a large extent on the design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards a Kid-Centric, Dynamic and Hybrid Theory of Consumer Socialization to Understand the Dynamics and Implications of the Kidfluencer Phenomenon.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

KIDFLUENCER will examine the dynamics of the kidfluencer phenomenon to understand its implications for children’s consumer socialization process. Kidfluencers are generation alpha children (born after 2010) that have highly popular profiles (+ 1.000 subscribers) on social media (e.g., Instagram or YouTube) on which they endorse fun and entertaining content, often containing (sponsored) brand endorsements. Past research merely focused on the negative impacts of kidfluencer activities, such as the commercial exploitation of kidfluencers or the deception of kid followers. This project takes an innovative approach by examining whether kidfluencer activities can be considered as pathways for empowerment and growth contributing to children’s consumer socialization process, while considering potential hazards. Using a three-pronged approach (inspired by cultivation theory), the production, content and impact of kidfluencer activities will be examined, giving a voice to kidfluencers, their entourage and followers. Unique compared to cultivation and consumer socialization research is that children will be considered as active co-creators in the research design, co-deciding upon methodological approaches. By challenging consumer socialization theory’s assumptions of a rational consumer and a linear consumer socialization process, I aim to obtain an in-depth understanding of how children’s consumer socialization process is changing in today’s digital age. A multi-method, longitudinal approach will be adopted, combining quantitative (digital traces netnography, experiments and survey) with qualitative methods (ethnography and expert interviews) to tackle the shortcomings of past research. This comprehensive approach will provide a solid knowledge base on how kidfluencers can be con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Endosomal control of local protein synthesis in axons' (AXONENDO) under Horizon 2020.

assistant: **Objectives**

Neurons are morphologically complex cells that rely on highly compartmentalized signaling to coordinate cellular functions. The endocytic pathway is a crucial trafficking route by which neurons integrate, spatially process and transfer information. Endosomal trafficking in axons and dendrites ensures that required molecules and signaling complexes are present where and when they are functionally needed thus fulfilling essential roles in neuronal physiology. Our recent work has revealed the presence of mRNAs and ribosomes on endosomes in axons, raising the exciting possibility that these motile organelles also directly modulate the local proteome by controlling de novo protein synthesis. However, the mechanisms by which endosomes regulate mRNA translation in neurons is unknown. Moreover, the roles of endosome-mediated control of protein synthesis in neuronal development and function have not been investigated. Here, we propose to bridge this knowledge gap by elucidating links between the endocytic pathway and local protein synthesis in neurons, focusing on their functional relationship in axons. By combining genome-wide analysis, genetic tools, state-of-the-art imaging techniques and the use of Xenopus and mouse vertebrate models, we plan to address the following fundamental questions: (i) What are the mRNAs associated with endosomes and does endosomal trafficking regulate their axonal localization? (ii) Does the endocytic pathway mediate the selective translation of axonal mRNAs in response to extracellular factors? (iii) What are the endosome-associated RNA-binding proteins, and what is the effect of perturbing these associations on axonal development and maintenance in vivo? (iv) Does impaired endosomal regulation of axonal mRNA localization and translation cause axon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '45HC.com' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ICT systems currently in use in the transport and logistics industry were found to be too inflexible to manage logistics processes, information is often exchanged and processed in unstructured ways (e.g. by telephone), and a lot of planning is still done by simple software tools. An expected outcome of the state of the art innovation 45HC.com, the first free online container booking platform, has the following added value to SMEs: free to use, provides an instant quote, and booking takes under 60 seconds instead of the current 12 days. Offers multiple carrier choice on one place instead of a dealing with each carrier one-to-one and searching for best offer, online insurance and a destination handling/cargo location system all in one place. SMEs will additionally benefit from the project output: a) economically: free of charge online container booking services; no hidden costs; loyalty discounts; better time management; much shorter transit time; greater efficiency of end-users` workforce; b) technically: online platform; 24/7 online booking, with an opt-in for EDI connection with the clients' operating system; responsive and optimised for use with any digital device, allowing booking and tracking shipments anywhere and at any time; error-free communication; price quote on the spot; the fastest booking available on the market; auto-printed insurance certificate; c) environmentally: paper-free, energy efficient.