RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SpeecH and Auditory Processing: Effects of Development' (SHAPED).

assistant: **Innovation**

Learning a language involves recognizing the acoustic properties of speech sounds that have a functional role. The abilities of perceiving and processing speech sounds are first constrained by basic hearing abilities. The auditory system extracts and processes the acoustic properties from the input language and thus, fully contributes to the development of phonetic categories. Surprisingly, information concerning the interaction between basic auditory capacities and early development of speech processing is still lacking. The present project seeks to combine two approaches to explore this interaction: developmental psycholinguistics, studying the acquisition of a language, and psychoacoustics, describing the auditory mechanisms linked to the perception of speech sounds. First, this project aims to investigate when and how auditory and speech processes interact. The perception of the speech acoustic information (such as spectro-temporal modulations described by psychoacoustic studies) will be assess in adults and infants from different language environments. Second, this project aims to explore further this interaction by investigating the effect of impaired auditory processes on speech perception development. The perception of speech acoustic information will be assessed in hearing-impaired children having access to the hearing world through hearing aids. This research project highlights an innovative multidisciplinary perspective within the speech perception development field. This project will have significant impacts on 1) general health (i.e., auditory rehabilitation for hearing-impaired children) and 2) language education (i.e., perception of foreign languages during development).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantum Network Steering' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Over the last decade, quantum networks have grown as one of the top candidates to greatly enhance secure processing, communication and computation of information. They exploit entanglement (distributed by photons) to establish correlations between distant systems that are stronger than possible with classical physics. These strong quantum correlations can boost technologies beyond classical limits: they provide a quantum advantage. However, common theoretical approaches to quantum networks suffer from the trade-off between quantum advantages, experimental demands, and security. A first approach is to fully-trust the implementation of network devices, i.e., to assume no defects or malicious behaviour. While optimally providing quantum advantages, this approach is vulnerable to malfunctioning or unnoticed hacking, rendering it insecure for applications. The second approach fully-distrusts the devices and assumes they are subjected to hacking attacks. While providing the highest-level of security, this approach is currently too demanding to practically implement it, rendering it unrealistic for near-term technologies. QNETS will overcome this challenge through the concept of quantum steering. In a steering approach, the network is composed of both, fully-trusted and fully-distrusted devices. It assigns a level of trust to each device individually depending on its role in the network, allowing for implementations of quantum networks under more realistic security assumptions using near-term technologies. In an inter-disciplinary effort, QNETS combines techniques from quantum information, applied mathematics, and computer science. In particular, QNETS will (1) lay out the theoretical foundation of quantum network steering (2) develop mathematical tools for its characterizatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Using chemical models to characterize potential specific medium effects in active sites of enzymes'.

assistant: **Innovation**

The remarkable catalytic proficiency of enzymes is ascribed to a combination of effects, including contribution from the active site medium. We aim to describe, quantify and exploit medium effects for catalysis in artificial enzyme mimics. In past work the Hollfelder group used polyethylene imines (PEIs) with modified surfaces to bring about efficient catalysis with rate accelerations per site up to 10e6 for a proton transfer reaction, thus creating active microenvironments.We will use a combination of high-throughput synthesis and high-throughput assays to identify successful catalysts from diverse libraries, containing PEIs with pendant hydrophobic, positive and negative groups, possibly coordinated to metal ion cofactors. Of particular interest will be the catalysis of phosphate transfer, for which we want to quantify the potential of medium effects. Our ultimate focus will be on kinetic analysis the catalytic solutions identified in structure-activity relationships for our combinatorial libraries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'CLIMATE ADAPTATION TO SHIFTING STOCKS'.

assistant: **Objectives**

Management of marine fisheries is still far from incorporating adaptation to climate change, even though global stocks are heavily overexploited and climate change is adding additional pressure to the resource.  In fact, there is growing evidence that current fisheries management systems may no longer be effective under climate change, and this will translate into both ecological and socioeconomic impacts. This research project argues that the combination of fisheries management science and socio-ecological systems thinking is necessary in order to advance in fisheries adaptation to climate change. To this end, the main objectives are set to: 1) Identify and understand the new challenges raised by climate change for current sustainable fisheries management; 2) Develop a novel approach to fisheries adaptation within a socio-ecological framework; 3) Provide empirical evidence on potential solutions for the adaptation of fisheries management systems; and 4) Help introduce fisheries adaptation at the top of the regional and international adaptation policy agendas. To do this, I will combine model and simulation approaches to fisheries with specific case studies where both biophysical and economic variables will be studied an modelled, but also individuals will be given the opportunity to participate in an active way, learning from participatory methods their preferences towards adaptation and the consequences of the new scenarios climate change poses. Three potential case studies are identified for property rights over stocks, property rights over space, and Marine Reserves in two European and one international case study areas. As a result, I expect to develop a new Adaptation Framework for fisheries management that can be scalable, transferable and easily operationalized,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Manipulating neuronal outgrowth using a novel pneumatic micro gene gun' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Dendrites and axons show extremely diverse forms, with important implications for nervous system wiring and neuronal function. How neurons acquire their morphology is a question of great importance for understanding neuronal development and regeneration. In this project, we will explore how the innervation of the epidermis, the major sensory organ for detecting mechanical stimuli, is achieved during embryogenesis. Specifically, we will study the development of the sensory cells that respond to pressure (P) on the skin of the medicinal leech, which are uniquely advantageous for this project because their large size and small number. Their sensory arbors innervate domains (“tiles”) that are organized in very regular patterns. Hence, it is easy to detect morphological changes produced experimentally. Moreover, following crush or axotomy these neurons can regenerate their branches and synaptic connections. Previous work showed that cell-cell interactions are fundamental for setting up sensory tiling. Our preliminary results indicate that molecular cues, such as the axon guidance cue netrin, which are heterogeneously distributed in the skin, play a key role in setting up sensory tiling. The overall goal of this proposal is to formulate a new developmental scheme for sensory neurons and to implement it to promote reinnervation of transplanted skin post trauma. In the proposed study, we will modulate the expression of factors, such as leech netrin, using a novel technology that enables the delivery of reagents into live tissue accurately. The technology, a pneumatic capillary gene gun, has been recently developed at UCSD (the P.I. with colleagues) and will be brought into the lab for the proposed project. We will affect gene expression in individual cells or in small groups of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Self After Interpersonal Loss' (SAIL).

assistant: **Innovation**

Losing someone can feel like losing a part of oneself. Do we need others to be ourselves? What happens to the self when we lose a loved one? How can people be adequately supported in times of grief?SAIL combines, for the first time, phenomenological evaluation, computational modeling, neuroimaging, psychopharmacology, and behavioral experiments to characterize the grieving self and to develop a novel, mechanism-based intervention with the goal of supporting adaptative processing of the loss.In an aging society, where people might outlive their partner by decades, it becomes crucial to improve support during times of grief, and to develop treatment options for those with prolonged grief disorder who are at a 20% increased mortality risk. Previous psychological research suggests that the loss of a close person affects self-identity, an aspect of the higher cognitive self. If the basis of the self, the bodily self, is also affected is unknown.Here, I combine the perspective of grief as a learning process with my previous work on the bodily self which I argue to be inherently social. In aim 1, I will use behavioral measures, neuroimaging, and computational modeling to characterize the self after interpersonal loss. In aim 2, I will employ a double-blind, active-placebo-controlled, between-subject study to test whether the serotonin-receptor-agonist psilocybin can improve adaptation to the loss experience by supporting the re-establishment of the bodily self. Psilocybin is suggested to cause a transient shift from reliance on prior experiences towards current sensations. I will utilize this shift combined with a self-touch intervention to support re-learning about the bodily self in grieving individuals. With this project, I aim to:Identify the psychological and neurobiologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Elucidating the effects of gut microbiota-derived metabolites in iPSC-derived co-cultures from ADHD patients' (ELEGANCE) targeting Horizon Europe.

assistant: **Abstract**

The pathophysiology of the most frequent neurodevelopmental disorder in the world, Attention Deficit Hyperactivity Disorder (ADHD), is influenced by the interaction of genetic and environmental risk factors. Studies have been indicating the association between ADHD and changes in the microbiota-gut-brain axis (MGBA), which may cause neuroinflammation, and subsequent microglial activation, secretion of cytokines and oxidative stress in the central nervous system. However, the precise mechanisms remain elusive and choosing a feasible individual-representative model to study pathomechanisms is challenging.ELEGANCE (ELucidating the Effects of Gut microbiota-derived metAbolites iN iPSC-derived co-Cultures from ADHD patiEnts) aims to investigate possible neuroprotective and neurotoxic properties of gut microbiota metabolites in induced pluripotent stem cell (iPSCs)-derived microglia and dopaminergic neurons from ADHD individuals in co-culture. Neuroinflammatory, oxidative stress and metabolic markers will be measured in different contexts (baseline and after treatment with potentially detrimental microbiota metabolites). Potential restoration effects by gut microbiota derived metabolites in compromised phenotypes will be also explored. These findings will elucidate interaction of microglia and dopaminergic neurons and gut microbiota derived metabolites in ADHD and thereby lead to promising novel drug targets. This fellowship will foster collaboration between world leading institutions and top-notch scientists, introducing me to the microbiome field, enhancing my expertise in transcriptomics, bioinformatics, networking and leadership. The project could significantly impact the knowledge about ADHD pathomechanisms and open doors for new treatment and dietary approaches targetin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Characterisation of mycobacterium tuberculosis populations during infection: a longitudinal study on drug resistance development' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Drug resistance arises in Mycobacterium tuberculosis (MTB) generally by mutation of chromosomal genes, but despite combined drug therapy the spread of multi-drug- resistant (MDR) strains is alarmingly increasing. The LONG-DRUG project is a longitudinal study, carried out in prisons and the civil society in an area with high MDR-TB prevalence, which aims to document the generation of multi drug resistant MTB strains through the use of novel molecular techniques. The combined use of a variety of techniques on longitudinally obtained samples and primary cultures will enable to generate clinically significant knowledge on the evolution of multi drug resistance in Mycobacterium.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Creep of Geomaterials' (CREEP).

assistant: **Concept**

Slow time-dependent movements caused by creep of natural geomaterials affect the performance of infrastructure and cause high maintenance and repair costs, and the partial closures of infrastructure networks during the repair work have significant economic and social impact. Although the phenomenon of creep is well-known for being a major design issue, there is currently no accepted consensus on the best way to model creep. Reliable calculation tools are either missing or - due to their scientific nature - out of reach for the engineer in charge. If as a consequence creep is underestimated in design, structures will possibly be damaged so that they will not reach their design life. On the other hand, if creep is overestimated, unnecessary countermeasures such as soil improvement, deep foundations, or additional structural reinforcement will take up additional resources. For sustainable building processes it is therefore imperative to adequately incorporate creep behaviour in analyses and design.The research topic of this Marie Curie action is creep behaviour of geomaterials and its incorporation in geotechnical design; the project aims at establishing a consensus in creep modelling. The project shall supply tools and knowledge needed in creep analysis. Past research in the field of creep behaviour of soils has concentrated mainly on soft silts and clays. Different theoretical frameworks and numerical models were proposed. Yet, creep is likewise observed in geomaterials such as peat, sand, rock fills, and warm permafrost. Key questions formulated by industry and academia are therefore: Can existing creep concepts be adopted equally for those materials? Can different creep concepts be unified? Of the alternatives proposed, which work best at both element level and real ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Feasibility Study for employing the uniquely powerful ESS linear accelerator to generate an intense neutrino beam for leptonic CP violation discovery and measurement.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

After the Big Bang, matter and antimatter were produced in equal quantities through materialization of the huge energy released. Observations show that today, however, there is a nearly total absence of antimatter in the Universe. The occurrence of Charge-Parity Violation (CPV) is a necessary condition for an explanation of this absence. CPV has already been observed in the quark sector but the measured amount is insufficient to explain the observed matter-antimatter asymmetry. Recent neutrino oscillation measurements indicate that the discovery of neutrino CPV becomes an important candidate to explain the observed matter dominance in the Universe. The goal of ESSnuSB project is to discover and measure neutrino CPV with unprecedented sensitivity. The ESSnuSB concept takes advantage of two outstanding opportunities. The first is the construction in Europe of the European Spallation Source, ESS, the world’s most intense proton source, with a beam power almost one order of magnitude higher than any other accelerator. The second is the recently measured unexpectedly large value of the oscillation mixing angle θ13. The latter fact implies that to obtain maximum sensitivity, the neutrino detector shall be placed at the second neutrino oscillation maximum, not at the first as implemented by the other proposed experiments. The Garpenberg mine in Sweden, in which it is proposed to install the underground neutrino detector, is situated at a distance from ESS that corresponds to the second maximum. The COST Action CA15139, “Combining forces for a novel European facility for neutrino-antineutrino symmetry-violation discovery”, already recognizes the necessity to have neutrino facilities in Europe. The goal of the ESSνSB H2020 Design Study is to organize European physicists and acce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development for new systems for measuring vibration velocity and distance, using the self mixing phenomenon' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

UTILISATION OF THE OPTICAL SELF MIXING PHENOMENON FOR THE DEVELOPMENT OF NOVEL NON CONTACT VIBRATION, VELOCITY AND DISTANCE SENSORS, RESEARCH OBJECTIVES : * identification and characterisation of light sources usable for self mixing, * thermal study of self mixing : modelisation, simulation, influence of temperature on the wave-length, * characterisation of spectral modulation relative to current excitation, * study and modelisation parasite phenomenas * detection of suitable ap^plications in different industrial sectors, * preliminary development of sensors.