RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identifying the proteins of the cochlear mechanoelectrical transduction machinery that are also involved in the development of auditory cortex interneurons.' in the context of a Horizon 2020 call.

assistant: **Objectives**

My long-term goal is to advance our understanding of the development and maturation of cortical neuronal microcircuits. My PhD focused on the role of adult brain plasticity in psychiatric diseases. I will now perform postdoctoral studies in the laboratory of Prof. Christine Petit, where a population of GABAergic interneuron precursors co-expressing two cadherin-related proteins, cdhr15 and cdhr23, from their birth in the medial ganglionic eminence to their final destination in the auditory cortex, was recently identified. Cdhr15 and cdhr23 and eight other proteins have been implicated in mechanoelectrical transduction in auditory sensory cells. In the brain, defects of cdhr15 or cdhr23 result in a deficit of parvalbumin-expressing interneurons in the auditory cortex only, and susceptibility to audiogenic seizures. Heterozygous Cdhr15+/- or Cdhr23+/- mice have smaller numbers of parvalbumin interneurons, but with considerable interindividual variability. The work proposed here aims to provide insight into the mechanisms involved in the development of this newly identified population of interneurons and their integration into the cortical microcircuits of the auditory cortex. I will address the following three questions: 1) Which other mechanoelectrical transduction proteins of sensory cells are involved in the development of interneurons in the brain? 2) What roles do cdhr15 and cdhr23 play in the migration of interneurons and their integration into the auditory cortex? and 3) Is the monoallelic expression of Cdhr15 and Cdhr23 responsible for the interindividual variability in Cdhr15+/- and Cdhr23+/- mice? This project will shed light on the extent to which people suffering from hereditary forms of deafness also suffer from cortical deficiencies, providing a scientific b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'STEM-TECH: Introducing proprietary stem cell marker technology for the life sciences market' (STEM-TECH).

assistant: **Concept**

STEM-TECH has been designed to investigate the commercial opportunity for exploiting our patented stem cell marker technology in the life sciences market. This proprietary technology will meet the need for new enabling technologies that unlock the potential of stem cell detection in academic, industrial and clinical research and practice.THE OPPORTUNITYThe stem cell market is a relatively immature market with an estimated size of around EUR 1 billion in 2011. It is expected that the market for stem cell technologies will increase substantially, mainly because leading biopharmaceutical companies are showing considerable interest in this area. Next to the pharma industry, major suppliers and small companies are now developing a wide range of stem cell approaches, which reflects the interest in this emerging area. Companies like Invitrogen provide reagents and services for stem cell research.THE PROJECTIn STEM-TECH the central aim is to commercialise a (cancer) stem cell detection technology that can be used in intestinal, skin, breast and brain (cancer) stem cell research for (not exhaustive):- Fundamental and applied research purposes, e.g. the study of stem cell behaviour or signaling in and ex vivo;- The development of clinical detection methods (diagnostics) for determining disease status and metastasis;- The development of treatments that are specifically targeted at cancer stem cells.THE FINAL GOALIn a 12 month project, the skilled team of STEM-TECH will analyse the business potential of the proprietary stem cell marker technology. Within this project we will validate the technology to increase value, conduct a detailed market research, file and define the IP stratetgy and develop a full fledged business plan. The path that results in the highest ratio of return ove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Harnessing Evidence on Adverse drug withdrawal events following Deprescribing through the Pharmacovigilance system (HEAD-P)' (HEAD-P) targeting Horizon Europe.

assistant: **Abstract**

Deprescribing (reducing or stopping unnecessary or harmful medications) is an important strategy to reduce the risk of medication harm – a significant and growing challenge for health systems as acknowledged by the World Health Organization. The aim of HEAD-P is to establish the current evidence base on adverse drug withdrawal events (ADWEs) and explore how this can be enhanced via the pharmacovigilance system. HEAD-P consists of 4 research objectives: to assess the rate of ADWEs in published trials of deprescribing; to examine the incidence of adverse events reporting related to ADWEs; to identify and review all recommendations related to the monitoring, detection, and reporting of ADWEs; and to investigate healthcare professional, patient, and policymaker perspectives on the integration of ADWE reporting in the pharmacovigilance system. The following research approaches will be employed: an umbrella review of systematic reviews, disproportionality analysis of key pharmacovigilance databases, a scoping review of sources of guidance, and qualitative semi-structured interviews. This innovative research will help address the significant gap in our knowledge of ADWE occurrence and will stimulate future studies and innovations. Moreover, this fellowship will provide me with valuable scientific (protocol development, quantitative data analysis relevant to pharmacovigilance data, qualitative research methods, data management, and synthesis skills) and transferrable (grant writing, research communication, and supervision and mentoring skills) skills. It will also provide me with valuable international, intersectoral, and interdisciplinary experience, and allow me to develop leaderships skills. The skills and experience I will gain by completing this Fellowship in the host orga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Consumer trust in food. a european study of the social and institutional conditions for the production of trust', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

This multidisciplinary study is directed towards the identification and analysis of factors that determine trust in the food supply. These factors include the roles of market actors, public authorities, consumers and consumer organisations. Comparative analyses including several types of data will be carried out. Representative consumer surveys will be conducted in six European countries - well balanced with regard to small/big countries in the north/south. Institutional studies (documents, interviews) of policy and market strategies will include country and EU levels. Two cases are focused: beef - a sector in crisis and transformation, and tomatoes - a less challenged sector. In the identification and application of trust enhancing strategies, a dialogue with European consumer groups and public authorities is emphasised. These, together with Sees and other stakeholders, also represent target groups in the dissemination program.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Why do fungi oxidize their cell wall carbohydrates?' under Horizon Europe.

assistant: **Concept**

The fungal cell wall (FCW) is the primary interface between the fungal cell and its surrounding. This statement applies to all types of fungi, regardless of whether they live in symbiosis, cause disease, or decompose organic matter. As smart architects, fungi have found ways to evolve the chemical composition of this wall (made mostly of carbohydrates) to thrive and constantly adapt to various environmental factors. To date, to which extent, how and what for the FCW is modified remains largely unknown. I hypothesize that fungi use “carbohydrate oxidases” (CarbOx) to cleave and/or functionalize their FCW carbohydrates, thereby altering their physico-chemical properties to fulfil diverse putative functions. In the FOX project, I will aim at unravelling the diversity and biological functions of FCW-active CarbOx.Here, using approaches at the interface between enzymology and microbiology, I propose to decipher the biological functions of pre-identified FCW-active CarbOx in a model filamentous fungus. Then, using an ad hoc methodology integrating in muro detection of oxidized carbohydrates, proteomics and computational modelling, we will draw a comprehensive portrait of FCW carbohydrate oxidation events and pinpoint responsible CarbOx. Building on these insights and methods, we will build experimentally-supported models to probe and test the occurence of these oxidative mechanisms across the fungal kingdom.By unravelling and providing a comprehensive understanding of the oxidative chemistry and function of CarbOx during FCW remodelling, my research will lay the conceptual and practical foundations of FCW oxidative enzymology. Given the involvement of fungi in a myriad of life-sustaining and threatening processes, as well as in industrial bioprocesses, I anticipate that FOX w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Network of Excellence in distributed and dependable computing systems' (CABERNET) under Fifth Framework.

assistant: **Objectives**

The present proposal is for a continuation of support, for a further 3 years, for the Network of Excellence in distributedand dependable computing systems: CaberNet. Founded in 1991, CaberNet has established a European community ofresearch groups and will now build on this strength to contribute directly to many of the themes highlighted in the ISTProgramme. Organising activities in Research Coordination and Training; Links to Industry and Information Services;it will enable members to work together more effectively on collaborative projects of wider interest and relevance thansimply the conduct of advance research. Examples include the publication of electronic newsletters; the jointproduction of training material and the investigation of advanced facilities for wide-area multi-media and computer-supported cooperative working. The present proposal is for a continuation of support, for a further 3 years, for the Network of Excellence in distributedand dependable computing systems: CaberNet. Founded in 1991, CaberNet has established a European community ofresearch groups and will now build on this strength to contribute directly to many of the themes highlighted in the ISTProgramme. Organising activities in Research Coordination and Training; Links to Industry and Information Services;it will enable members to work together more effectively on collaborative projects of wider interest and relevance thansimply the conduct of advance research. Examples include the publication of electronic newsletters; the jointproduction of training material and the investigation of advanced facilities for wide-area multi-media and computer-supported cooperative working. OBJECTIVESThe mission of CaberNet is to coordinate top-ranking European research in distributed and dependable systems,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'HIPFLAPP: High Precision Flavoured Particle Production at the Large Hadron Collider' in the context of a Horizon Europe call.

assistant: **Objectives**

The project will develop and exploit theoretical calculations to study particle collisions that feature heavy flavours, namely the charm quark and beauty quark, at the Large Hadron Collider. Identifying heavy quarks is critical to pinpoint specific scattering processes and reject backgrounds, resulting in an unique opportunity to probe the structure of the proton, to improve our understanding of the Higgs mechanism and to possibly unveil the presence of new physics signals in the LHC data. On the theoretical side, the accuracy and the precision of phenomenological predictions must be increased to keep up with the progressively smaller uncertainty on experimental measurements, so that reliable comparisons with experimental data can be performed. More specifically, the project will focus on very accurate computations in quantum chromodynamics to better describe the production of flavoured particles across a wide kinematic range, so that no region of phase-space is left unexplored: these theory predictions will require a combination of both fixed-order and all-order perturbative calculations in the strong coupling constant. A public code with the implementation of the predictions for heavy hadron production at ultimate precision will be assembled, hence providing other researchers in theoretical physics and the experimental collaborations with a valuable tool in the LHC precision era.


**Keywords:** QCD, Heavy quarks, Precision calculations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Strongly correlated phenomena in twisted bilayers of graphene and transition metal dichacogenides' (TWISTM) targeting Horizon 2020.

assistant: **Abstract**

Fundamental properties of 2D materials are dramatically modified when they are brought next to each other to form a vertical heterostructure. Then, the combination of the 2D layers as well as the relative orientation between them ultimately determines the performance of the new hybrid material. This presents tremendous new opportunities for manipulating the behaviour of 2D layered materials and ultimately achieving unprecedented control over their performance when integrated into highly specific functional devices.However, research in this field is in its nascent stage and many exciting phenomena remain to be discovered. The main objective of TWISTM is to unravel the most fundamental properties of unexplored graphene- and transition metal dichalcogenide-based bilayers arising from many-body interactions. Progress here requires of a comprehensive microscopic picture of the fundamental properties of the heterostructures in clear connection to their macroscopic behaviour. TWISTM will tackle this challenge by using local probe techniques (STM and s-SNOM) with sub-nm resolution combined with mesoscopic electron transport measurements on in-house engineered twisted bilayers with accurate misalignment angles. TWISTM comprises three goals: i) to develop and optimize a fabrication method towards the achievement of high-quality twisted bilayers, ii) a multiscale search for collective electronic and optical phenomena arising from the coupling between the layers; iii) A full characterization of the superconducting and magnetic properties as a function of the chosen materials combination and twist angle. Overall the project aims at acquiring fundamental scientific knowledge with potential for technological applications that will be useful in both academia and industry. Furthermore,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The 1429 Catalan Translation of Giovanni Boccaccio’s “Decameron:” Tracing the Making of a European Classic' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Composed in the wake of the Black Death (1348), the Decameron is a foundational text in the construction of European cultural identity. It profoundly influenced the form and content of narrative fiction in diverse western European traditions, in a process in which translation played a major part. This proposal seeks to analyse the 1429 Catalan translation of Boccaccio’s Decameron through a set of interrelated studies, including a partial digital edition. The Catalan text will be considered both in its own right and in its relations with readings and rewritings of the Decameron across different countries (France and Italy) and social milieus (the courtly nobility and rising urban bourgeoisie).The Catalan Decameron poses distinctive problems to scholars, since it is the result of a dynamic, and particularly complex, process of textual and linguistic sedimentation. To do justice to this process, DecameronTranslated draws on a multidisciplinary approach that brings codicology, palaeography and textual criticism together with digital resource development, and that is informed by key insights from reception theory and translation studies. Study of the complete Catalan text, its process of composition and its relationship with the Italian and French tradition of the Decameron, will generate a digital edition of Day 10 and a short monograph on the complete work.By building on my existing competencies, and by giving me high-level skills in applying digital tools to studying and editing pre-modern texts, the DecameronTranslated project would enable me to deliver expertise that is increasingly in demand throughout Europe, including in my home institution. This will equip me to take on research leadership roles, and to have an impact on scholarship across an unusually wide range of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative and advanced manufacturing process to produce biological nanomaterial super-capacitors for superior battery performance in smart devices' (Capacitoxx).

assistant: **Innovation**

Many current smart devices are let down by their battery life. Smartphones, for example, can only survive on a single full charge for less than a day. This is caused by the low storage capacity currently available with this technology, which only looks to become worse as batteries can’t keep up with the power consumption of electronics from Moore’s Law (smartphones are 16 times more powerful than 9 years ago. When the device does need to be charged it can take from 1.5-2.5 hours and the battery will eventually stop functioning after only 100 charges, or 1-3 years.Pntlloxx have developed a small super-capacitor that combines with a rechargeable battery to create a hybrid-cell to be used with smart devices. The use of Capacitoxx allows for rapid charging times, giving a smart device a full charge in less than a second, and a lifespan of over 10 years (nearly 1M charges). Energy density is also significantly increased to allow users to operate smart devices for over a week on a single charge. This reduces battery wastage, pollution, and purchasing cost found with existing solutions.Following a very promising preliminary validation of our innovative technology during initial in-house tests, developments will begin to optimise and design the integrated system to be fully commercialized by reaching the market in 2021. Incorporated in the Israel in 2016 with its core business in the smart device battery market, Pntlloxx have received €500K in funding and have a staff headcount of 4 working on the solution.The proposed work in Phase 1 of the SME instrument fits into the overall Pntlloxx plan to reach market by contributing the financial resources needed to plan a fast, sound and wider deployment of the Capacitoxx solution and the market uptake. It will also allow the SME to acc