RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Patient specific modelling and simulation of focused ultrasound in moving organs' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In recent years, High-Intensity Focused Ultrasound and Focused Ultrasound (FUS) have become frequent tools for non-invasive benign tumour therapy. Applications in the treatment of fibroadenoma of uterus has become commercial and passed FDA clearance in 2004 and sonication of bone metastasis has obtained a CE mark. Other tumours are under preclinical (prostate, kidney) and clinical (breast, brain and liver) evaluation. However, treating tumours with focused ultrasound is still challenging in terms of reliable therapy planning, monitoring and outcome prediction especially in moving organs with a complex blood supply. It is important to understand that the processes involved in FUS therapy are multi-level ranging from organ morphology, perfusion and motion, down to microscopic and cellular level. The relation within and between these levels is not well understood.FUSIMO will develop, implement and validate a multi-level model for moving abdominal organs for use with FUS and Magnetic resonance-guided focused ultrasound surgery. The overall model will consist of several sub-models, which interact and describe aspects in a hierarchical manner. The integrated model will consist of;- Abdominal organ model to simulate motion and the influence on ultrasound application- Target organ/tumour model to capture organ/tumour physiology, and organ/tumour reaction to therapy- Microscopic tissue model to simulate direct heat ablation, model energy distribution, tissue heating and cooling- Model to evaluate first steps to simulate drug delivery, microbubble distribution and dynamicsThe FUSIMO developments in the field of hardware and software will be combined into an integrated system, which will allow both abdominal FUS application to moving organs, and also other treatment modalities suc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Evaluation and customisation of electro-magnetic (EM) simulation tools for use in advanced antenna array applications' to be submitted under Sixth Framework.

assistant: **Abstract**

Simulation software of EM fields and wave propagation of large antenna arrays and macro-environments has today a dimensional limit. Generally, this means surfaces less than 25 wavelengths a side or volumes of the same area and less than 1 wavelength thick.A goal for the Mid-Sweden University and its industrial partner (Telewide) is to simulate a whole microwave antenna system including both source and antenna. Unfortunately, the large and complicated antenna structure could not be simulated by more than a part, one hundred of the total antenna with the best presently available Electromagnetic Field Solvers of today.With a new approach to solve large array problems, combined with the use of parallel supercomputer, the size of structures and environments that is needed to simulate will be met. With this goal met, Telewide can continue its work on developing waveguide lens antenna technology and being the leader in that field.The result of this research will be not only the possibility to simulate the antenna but also any other complex and large (compared to the wavelength) structure. It will be possible to simulate structures many times larger than before.The needs in the region for simulating large structures can be found in the development of complex antennas, in the construction of new microwave scanning systems in the wood industry and in research in fields of wireless LANs that cover a larger city area.The research group at Mid Sweden University will have access to European networks within the area of microwave theory and software development and transfer their knowledge to regional companies and research institutes as well as their master students.As the parallel supercomputer and the software will be available via Internet, it can serve any European re search insti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Photonic Integrated Microcombs as Multi-wavelength Sources for Edge Data Centers' in the context of a Horizon 2020 call.

assistant: **Objectives**

Over the past ten years the Laboratory of Photonics and Quantum Measurements (LPQM) has developed and pioneered microcombs – photonic integrated optical frequency combs (OFC), providing access to equidistant optical carriers. Due to their broad bandwidth, high repetition rates, compactness and wafer-scale fabrication, such microcombs represent a novel disruptive technology with a proven track record. While their advantages were shown in ultrafast ranging (LIDAR), high-speed coherent telecommunications, as well as chip-scale atomic clocks and frequency synthesizers, the technology is not yet commercially available and only present in a few research laboratories worldwide.Recent LPQM advances have led to the development of unique proprietary Si3N4 microfabrication processes for ultra-low-power microcombs, and allowed in-house photonic packaging. Taken together the laboratory is now able to implement full-cycle production of a packaged microcomb ready for the integration into a commercial product. We aim to bring the technology to the market by building and promoting a rack-mountable microcomb unit with 100 GHz channel spacing matching the ITU frequency grid over C- and L- telecom bands. The key market segments of the proposed microcomb unit are enterprise and edge data centers, facing growing data traffic and requiring WDM sources for high-speed interconnects. The product will be tested in collaboration with Microsoft UK in an actual data center application as a WDM source for optical circuit switching. We also plan to showcase the technology to Huawei and Nokia Bell Labs who expressed interest in testing. Beyond field-testing with industry partners, the system will be shown at international industry trade fairs to address key stakeholders. The project aims to incorporate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ecosystems, Societies, Consilience, Precautionary principle: Development of an assessment method of the societal cost for best fishing practices and efficient public policies' in the context of a Sixth Framework call.

assistant: **Objectives**

The main aim of the ECOST project is to develop a new approach to assess the societal cost of fishing activities to the ecosystem. By societal cost we mean all costs linked to fishing activities: this may be ecological (alteration of the capacity of a system), economic (all costs linked to production, management, subsidies, and external factors), social (linked to choices made in public policy, food safety, provision for national or international markets, the eradication of poverty, and to development models (small scale fishing versus industrial fishing)). The geographical dimension of the work is spread over 3 continents (3 countries for each continent) which are characterized respectively by ecosystems of coastal upwelling (West Africa), delta (South East Asia) and coral reef (Caribbean) Within each region/ecosystem (eco-region) several fisheries have been selected as representative of global fishing activities. Furthermore, a marine protected area will be chosen in order to establish comparative analysis within the said eco-region, and to serve as a reference point The programme is organised into 12 work plans (WP), each one is sanctioned by the delivery of a product which marks a stage in the development process of the evaluation method for the impact made by fishing activities. The common ground for the complete work plan is the development of a method for a greater and more complete understanding of the ecological, economic and social incidence of fishing activities on the various eco-regions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nanofiber-Based Optical Drag Force and Cavity Quantum Electrodynamics' in the context of a Seventh Framework call.

assistant: **Objectives**

Recently, it has been shown theoretically that strongly non-paraxial Bessel beams can exert an optical force on a particle that drags the latter towards the light source.  However, an experimental verification of the existence of an optical drag force (ODF) with Bessel beams is very challenging. In the first subproject, we therefore propose to theoretically investigate the possibility of realizing an ODF acting on particles in the evanescent field of highly non-paraxial modes sustained by high-index optical nanofibers. Nanofiber modes are promising candidates for such investigations because they can exhibit wormhole regions with negative Poynting vector in their evanescent field. Moreover, a possible ODF could be straightforwardly demonstrated because the mode might provide both the tractor force and a gradient force that automatically traps the particles in the region with a backward force. Beyond the fundamental interest of demonstrating an ODF, its implementation with nanofiber modes may find important applications in both science and technology.In the second subproject, we propose to theoretically investigate cavity quantum electrodynamical (CQED) effects for an ensemble of fiber-trapped atoms coupled to a nanofiber-based cavity (NFC). Due to the strong lateral confinement of the NFC mode, the CQED effects prevail even if the NFC finesse is moderate (∼100) and the resonator is comparatively long (∼10 cm). Such NFCs have recently been demonstrated experimentally. Moreover, cold neutral atoms have recently been trapped and optically interfaced in the evanescent field surrounding optical nanofibers. It is therefore very timely highly appealing to consider the combination of NFCs with such nanofiber-trapped atoms.  We will therefore establish the theoretical framework f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identifying ecological and epidemiological key factors for rabies dynamics and control in North Africa and implications for rabies status in South West Europe' (RABMEDCONTROL).

assistant: **Innovation**

Rabies is a serious public health concern in N.Afr. and its réintroduction to Western European countries presently free of rabies in non-flying animals represents a serious threat. This project will address a global multidisciplinary approach to draw a pre cise picture of the rabies epidemiology in N.Afr. by identifying and quantifying epidemiological, ecological, sociological and vaccinological key factors for rabies dynamics. Furthermore and despite that the Western European countries have almost completel y eliminated canine and vulpine rabies, they continue to declare some human and animal cases mostly imported from North Africa in addition to the presence of the disease in bats with some spillover to humans. Therefore the study of rabies in N.Afr. and Wes t Europe will determine the possible overlapping of rabies epidemiological cycles between the Western European and North African shores. Therefore baseline epidemiological data on human and animal rabies will be collected and analyzed by GIS in 4 N.African countries for the identification of rabies hyperactive areas. Factors which contribute tohuman post-exposure therapy failures will be identified. KAPsurveys will be addressed in order to weigh out key ethologie factors of dogs and the impact of human soci o-cultural perturbations and human behavior which may play a role in rabies dynamics and vaccination efficiency. Phylogenetic analysis will be carried out on rabies isolates collected from North Africa or of imported casesrecorded in 3 European countries b ordering the Mediterranean sea as well as bat lyssaviruses. We will try toelucidate whether lyssaviruses (rabies and rabies-related viruses) are circulating in bats in N.Africa. Circumstantial data indicating exchange of bats between Europe and Africa most li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Engineered bacterial Outer Membrane Vesicles (OMVs) for colorectal cancer immunotherapy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This proposal originates from recent results obtained in the course of the Advanced ERC Project “OMVac”, the scope of which is to exploit the unique adjuvanticity properties of bacterial Outer Membrane Vesicles (OMVs) for developing innovative vaccines against infectious diseases and cancer. In particular, Synthetic Biology was applied to engineer OMVs with FAT1, a tumour associated antigen expressed in most primary and metastatic colorectal cancers (CRC). Using cancer models in immunocompetent mice, immunization with FAT1-decorated OMVs inhibited subcutaneous growth of FAT1-positive CT26 cancer cells and protection correlated with an increase in tumour infiltration of CD4+/CD8+ T cells and concomitant decrease of Treg and MDSCs. These promising results prompted the submission of the present proposal which has as main objectives: 1) the demonstration that FAT1-OMV immunization can synergise with the protective activity of checkpoint inhibitors, and 2) the development of a scalable FAT1-OMV production and purification process which could allow testing FAT1-OMV/checkpoint inhibitor combination in the clinical setting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exchange of foresight relevant experiences for small european and enlargement countries' (EFORESEE).

assistant: **Innovation**

Malta and Cyprus are in the process of establishing foresight exercises intended to help in the coordination of national RTD and innovation efforts, support capacity building and integrate these countries into the European Research Area. Experience from the past has underlined the challenge of implementing foresight actions in small economies or in regions with limited human resources and limited support for RTD and innovation activity. foresee will develop methodologies for foresight actions with constraints - limited human resources, limited local infrastructure and shorter time-horizons. The approach is based on a review and analysis of case-studies from smaller countries and regions of Europe . The local foresight teams will receive training and coaching. They will design, implement and evaluate pilot foresight actions based on methodologies developed for their specific objectives and constraints.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identification of tyrosine kinases involved in phagocytosis and phagosome-lysosome fusion' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives, and content Phagocytosis and phagosome-lysosome (PLF) fusion are key events in killing of microorganisms. Certain bacteria, such as Mycobacterium tubercolosis (Mtb) and Chlamydia trachomatis (Ct), can survive within phagosomes which do not fuse with lysosomes. Recent evidence suggested that protein tyrosine phosphorylation may represent a key signal in mediating phagocytosis and PLF. My project is to address several topics related to the role played by tyrosine kinases in phagocytosis of pathogens and in PLF. These topics can be summarized as follows. 1. Activation of tyrosine kinase activities during phagocytosis of complement- or IgG-opsonized particles, and Mtb and Ct in human neutrophils and monocytes. This topic will be addressed analyzing activity of distinct tyrosine kinases in phagocytes challenged with injecstible particles. Kinases analyzed will be Src-family tyrosine kinases (Lyn, Fgr, Hck) and p72syk. The specific aim of this line of experimentation is to identify kinases involved in phagocytosis and possibly PLF 2. Redistribution of tyrosine kinases, tyrosine phosphorylated and cytoskeletal proteins and annexins to the phagosome surface following phagocytosis of complement- or IgG-opsonized particles, and Mtb and Ct. This topic will be addressed by fluorescence microscopy analysis. The specific aim of this line of experimentation is to define proteins redistributed to the phagosomal membrane and possible alterations of this redistribution during phagocytosis of Mtb and Ct. 3. Analysis of phagocytosis, PLF and bacterial growth and survival in neutrophils and macrophages isolated from mice with the selective deficiency of the Src-family tyrosine kinases Fgr, Hck and Lyn. This topic will be addressed by using phagocytes from mice with targ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Drug-loaded nanobots for transmucosal delivery to mucinous tumours'.

assistant: **Objectives**

Mucus is a defensive barrier that protects the underlying cells from pathogens and toxic compounds, although it also hinders the delivery of drugs whenever they are administered locally. There are different types of mucus-secreting tumours, such as pseudomyxoma peritonei (PMP), that could benefit from more efficient transmucosal delivery of anti-cancer drugs. PMP is a rare disease and the most mucinous tumour type, thus it will be used as a proof of concept for this project. In fact, it is characterised by the production of abundant mucus in the peritoneal cavity and is treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy, usually Mitomycin C. This approach has extended patient survival, but there is a significant proportion of recurrence, most probably due to the shielding effect of mucus. Therefore, there is an urgent need to offer new therapeutic strategies to PMP patients. Recently, Dr. Palmer’s lab has established a collection of PMP patient-derived organoids and xenografts and has shown that some PMP patients present oncogenic BRAFV600E mutations, introducing a new druggable targeted mutation. In this proposal, Dr. Sánchez’s lab (IBEC), in collaboration with Dr. Palmer’s research group (VHIO), aims to use nanobots able to overcome the mucus barrier that will be loaded with Mitomycin C or Encorafenib (BRAF inhibitor) to treat PMP. A comparative study will be performed to assess the treatment’s efficacy compared to the standard of care, and medical advice will be received from Dr. Élez (VHUH) to ensure the translation of the results to the clinic. We believe that using this all-in-one system will certainly enhance the delivery and efficacy of the active therapeutic compound, thus potentially improving current treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced Solar Tracking for Resilient Energy Systems' (ASTRA-RES) targeting Horizon Europe.

assistant: **Abstract**

Solar photovoltaics (PV) dominate new electricity deployments globally, but this growth causes a mismatch between electricity supply and demand that can disrupt electricity markets and limit further PV adoption. This challenge is mitigated by single-axis trackers (SATs), which rotate PV panels to follow the sun, creating a wider daily generation profile and increasing electricity output by up to 25% compared to fixed-tilt systems. However, standard SAT algorithms are inadequate for regions with variable terrain or frequent cloud cover. This leads to energy losses and lower profits, slowing solar deployment in otherwise promising locations. This project aims to develop advanced tracking algorithms that maximize the power output of SAT systems in these challenging conditions. These novel algorithms are expected to increase energy yield by 1-4% with no additional hardware costs. The algorithms will be validated at scale on over 10 MW of operational solar plants in direct collaboration with industry partners. Model and field results will quantify the impact of advanced tracking on PV plant energy generation and profitability. The results will then be integrated into a European energy system model to demonstrate the benefits for energy system reliability. By increasing the efficiency, profitability, and versatility of solar power plants, this project will accelerate the adoption of renewable energy and support Europe’s decarbonization goals. All models, algorithms, and datasets will be released as open-source resources, ensuring widespread scientific and industrial impact.