RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Connecting advisers to boost interactive innovation in agriculture and forestry' (2014-2020).

assistant: **Innovation**

The i2connect project aims to fuel the competencies of advisors who will support and facilitate interactive innovation  processes responding to multiple challenges in European agriculture and forestry. The strategy in i2connect is to use the existing advisor networks and the experiences of success in different contexts to create a broader network and momentum of change enabling a new culture of bottom-up led innovation support. This resource of over 40,000 advisors are critical actors supporting agriculture and forestry on the ground and must be influenced in this project to support interactively innovation with particular emphasis on EIP-AGRI 2020 target of 3,500 operational groups and beyond.An inventory will be made of the current state of advisory practices in Europe. Best Practices throughout Europe will be analysed in an interactive way to guide the development of approaches and tools, and to be studied as part of the training program for advisors. A pool of trainers will be trained to work with these materials in training and coaching advisors. Some advisors may join cross visit teams for studying interesting cases abroad. Attention will also be given to the ‘enabling environment’: ways in which managers of advisory services, research actors, policy makers and others can create conditions. These activities feed into a professional network with many local branches, supported by the project through a moderated on line platform for mutual coaching, sharing experiences. i2connect brings together 32 organisations (beneficiaries and third parties).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Sustainable halophyte utilization in the Mediterranean and subtropical dry regions'.

assistant: **Concept**

The Concerted Action has the following objectives:* Demonstration of the feasibility of seawater irrigation cropping systems.* Collection and disseminate all information needed to maintain and utilise halophytic plants and ecosystems in ecologically different environments.* Developing a quick check for the salinity tolerance of halophytic plants.* Testing seawater irrigated systems in different climates.* Demonstration of the feasibility of seawater irrigated ecosystems for landscape management, agriculture, horticulture, greenification of housing areas, wasteland and roadsides, roof greenification, sand dune stabilisation.Expected Outcome* Solidly founded experience about saline irrigation techniques* Basis for economically feasible saline irrigation projects.* Selection of plants, animals and cultivation systems ready for application.* Creation of a team of experts in saline irrigation.* Preparation of a textbook.* Display of a pretested, working model of saline irrigation based on solar energy utilisation at the EXPO 2000.* Information of potential users as well as the general public about the feasibility of sustainable halophyte utilisation through seminars, congresses and exhibits in fairs.* Stimulation of saline irrigation projects at feasible locations including:* Regular meetings of the members of the CA group with scientists and engineers of related interest.* Generating a network of saline irrigation specialists around the Mediterranean and Near East countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Vital Elements and Postcolonial Moves: Forensics as the Art of Paying Attention in a Mediterranean Harbour Town' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

For more than a decade, the dead bodies of people who had hoped to cross the Mediterranean have been washing ashore on the beaches of Zarzis, a coastal town in southern Tunisia. This research program starts out from the question: How did these bodies end up here?While in Europe people who are adrift may be seen as evidence of a migration crisis, from the African side of the Mediterranean they point to the chronic, (neo-)colonial depletion of livelihoods. To map how life is enduringly made unliveable, this program develops the method of forensics as the art of paying attention. This method will allow us to trail exemplary vital elementsresources crucial for fostering life and livelihoodand the relations between them. Our cases include: the extraction of phosphate, the fishing of sea sponges, the cultivation of tomatoes, the extraction of water, and the leaving behind of industrial waste.To better understand the complexity of, and material semiotic relations between, vital elements, we focus on Zarzis as a nodal point. This will make it possible for team members to visit each others sites and to work together in a Method Lab as well as to collaborate with local artists who will help to sensitise us to local concerns in a Vital Elements Atelier.The research program is innovative in three ways: it (1) contributes to a decolonial shift of attention from the migration crisis befalling Europe to the chronic depletion of life afflicting Africa; (2) develops the method of forensics as an art of paying attention to ethnographically study the complexity of, and the relations between, vital elements and the ways they impact on living and dying; (3) advances the concept of vital elements for materialities that are active, make connections and foster life, or spur on death.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An Innovative Mass Spectrometry-Based Workflow for Drug Discovery' in the context of a Horizon 2020 call.

assistant: **Objectives**

Pulmonary Arterial Hypertension (PAH) is a life-threatening condition; even if treated, patients only have a 5-year survival rate of less than 60%. For the treatment of PAH, Chiesi Pharmaceuticals develops Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitors.The aim of this project is to elucidate conformational changes in ROCK in vitro as well as in the cellular environment that are induced by anti-PAH drug candidates, which are currently being tested in preclinical trials at Chiesi Pharmaceuticals. The ROCK interactome will be mapped to gain detailed insights into the molecular mechanisms underlying the signaling pathways of ROCK. We will decipher the effect of anti-PAH drug candidates on the ROCK interactome and elucidate drug-induced conformational changes in ROCK. Identifying novel pharmacological targets modulating specific ROCK/protein interactions will eventually lead to novel drugs for an improved treatment of PAH. This project will integrate, for the first time, in cell cross-lining mass spectrometry (XLMS), in conjunction with hydrogen/deuterium exchange mass spectrometry (HDX-MS), in the drug discovery pipeline of a pharma company. It will be the first application of the XLMS approach in the field of structural biology in Italy. The conformations and interactions of ROCK, derived by in cell XLMS, will allow a systematic validation of in vitro biochemical studies. This project aims to advance the in cell XLMS approach into a routine method for drug discovery on the system-wide level that complements HDX-MS studies using isolated proteins. Novel cross-linking reagent will be developed to bring the XLMS approach to a new level of time-resolved protein interaction studies. As such, the integrated approach described herein opens unmatched and n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ZBP1-induced Inflammation and REcognition of Z-Nucleic Acids' in the context of a Horizon Europe call.

assistant: **Objectives**

Nucleic acids are potent inducers of an immune response. Nucleic acids normally exist in a right-handed conformation. However, during conditions of cellular stress, nucleic acids can also adopt an unusual, left-handed “Z-form”. These Z-nucleic acids, including Z-RNA and Z-DNA, are sensed by two proteins: ADAR1 and ZBP1. While ADAR1 binding to Z-nucleic acids prevents immune responses, activation of ZBP1 results in the activation of an innate immune response. It is clear, that ZBP1 has important functions in antiviral defence, cancer immunity and during autoinflammation, yet the mechanisms that govern its activation and which pathways downstream of ZBP1 are activated, is poorly understood. Additionally, a big hurdle currently preventing the molecular characterisation of ZBP1 signalling, is the lack of a selective ZBP1 agonist.I hypothesise that understanding the molecular mechanisms regulating ZBP1 activation and its downstream signalling pathways is fundamental for the development of therapeutics targeting this pathway. To test this hypothesis, I will address three major knowledge gaps in ZBP1 biology: (i) by purification of active ZBP1 complexes followed by nanopore sequencing and through solid-phase nucleic acid synthesis, I will generate a bona fide ZBP1 agonist, (ii) I will validate the ZBP1 agonist in vivo by testing its adjuvanticity in a mouse vaccination model, and (iii) by using a small compound and a genome-wide CRISPR/Cas9 knockout approaches, I will identify upstream and downstream regulators of ZBP1 signalling. Together, my proposed research plan will contribute to understanding the activation mechanisms of ZBP1, as well as its regulatory factors laying the foundation for understanding human ZBP1-driven (patho)physiology and development of therapeutic inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Custom, Environment, and Comfort made shoe' in the context of a Sixth Framework call.

assistant: **Objectives**

Manufacturing in developed countries has declined in many sectors including footwear, largely caused by labour intensive processes accompanied by high labour costs. However, it is largely acknowledged that manufacturing cannot be lost. This is particularly true for the footwear sector, since preserving a shoe making capability in Europe is considered vital for the future of the sector, in terms of employment, quality of products, service contents and kind of entrepreneurship of European companies While the sector in Europe needs to transform itself from an industry driven, Resource Based activity to a market led Knowledge Based activity, it is essential that it maintains its advantage in style and fashion. To build a Knowledge Society and a Knowledge Manufacturing does not mean to concentrate only on the Style and Design phase but it also means to be able to master the whole product and process life cycle adding value (knowledge and intangible) to each phase. To this end a breakthrough strategy, based on R&D regarding products, processes, materials, organization and a widespread use of Information and Communication Technologies, are proposed. It consists of creating and implementing, through the mechanism of the Integrated Project, a Knowledge Producing and Transforming Community (KPTC), encompassing from foresight to implementation of the Research - Industrial Innovation value chain, capable of:Perceiving strategic changes in human, societal, economical needs and technological potentials as a permanent foresight bodyMaking plans and providing resources for developing knowledge concerning products, processes, materials and organizations and turning such knowledge into industrial technology Transferring and implementing it into products, processes, materials, organizatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Smart, energy efficient air-condition'.

assistant: **Objectives**

Air-conditioning is a vital technology in many regions to ensure comfort, health and productivity but it consumes a lot ofelectricity and is thus expensive and environmentally harmful if fossil fuel-based electricity is used. Commercial chillers used in large buildings, such as hotels and office blocks, account for more than 30% of installed a/c capacityworldwide. However, the technology used is static and dated: it chills the water to a very low temperature so that it can copewith extremely hot weather, irrespective of the actual prevailing conditions. Keeping the chiller water colder than it needs tobe leads to excess electricity consumption. Elencon has invented and developed a unique plug-and-play technology: usingIoT sensors and machine learning, the system analyses a building's thermodynamic map and usage patterns andcombines this with hourly weather forecasts and dynamic electricity pricing to set the chiller water to an optimal temperature,which is almost always higher than current set minimums. Prototype trials have shown that this reduces electricityconsumption by 25 - 35%. In the case of one of our trial customers, a hotel in Tel Aviv, this translates into savings of €70,000 p.a. The energy savings increase with the installed cooling power and frequency of use, which means that users offacilities with high cooling requirements save the most. We believe that our serviceable addressable market in SouthernEurope and Israel is worth hundreds of millions, and that the global market is worth billions. Our technology is at TRL 7 andwe've validated a shared savings model e.g. with large hotel chain, as well as with distributors in Israel, ItalyandCyprus. With our Phase 1 project, we aim to develop the most suitable go-to-market strategy, ensure can serve key-segments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Neuroscience Training in Europe' (NEUROTRAIN) targeting Sixth Framework.

assistant: **Abstract**

The cost of brain disorders in Europe has recently been estimated to amount to 386 billion. Furthermore, the brain is the only organ whose physiological functioning is far from being completely understood.These facts indicate the need for further brain research and specific training of young researchers in the field. Neuroscience schools in Europe have been carried out by several multi- and monodisciplinary societies, on a rather spotty and non-standardised scale.The NEUROTRAIN project will provide a standard platform for neuroscience training by offering a series of 4 events to implement a school system standardised coherently in relation to structure, program frame, industrial aspects, complementary skills, event management, selection of high quality scientists, topics and tutors, and evaluation after events to enable continuous improvement.The project starts with a satellite event of the FENS Forum 2006 and is followed by three schools on topics in which Europe has a strong interest, contributing to t he uptake of most recent advances by European researchers.All the events address brain function and dysfunction linked by neuroplasticity as common key mechanism in adult brain development (e.g. for learning and memory as well as for recovery of the injured brain).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional Genomics of Fatty Acid Desaturases in Caenorhabditis elegans' under Seventh Framework.

assistant: **Concept**

The aim of this proposal is to characterize the metabolic impact of the expression of key transcripts involved in fatty acid metabolism by using the model organism Caenorhabditis elegans. In particular, the main focus of the project will be on the systemic manipulation of the expression of genes for the fatty acid desaturases by an RNAi based intervention to understand their key role as regulatory control points in metabolism. To achieve this aim we will make use of state of the art metabolomic approaches including Nuclear Magnetic Resonance (NMR) spectroscopy, Gas Chromatography Mass Spectroscopy (GC-MS) and Liquid chromatography Mass Spectrometry (LC-MS) to provide a global, non-targeted description of systemic metabolism. Metabolomic analysis, conducted on different genetically modified animals, will result in a rich data-base of metabolomic profiles that, with the help of multivariate data analysis techniques, will permit the identification of specific biochemical markers that determine which pathways have been perturbed. In addition, we will also analyze flux changes directly using stable isotope labelled substrates experiments. The combination of steady state concentration data and flux changes will provide a description of the reorganization of the metabolism following the targeting of a given gene by our RNAi based intervention. Overall, the results will allow a global insight into consequences of altered genetic expression across the whole system of metabolism without any loss of intrinsic complexity - a so-called top-down systems biology approach. In addition understanding the metabolic roles the desaturases play in regulating global lipid metabolism will help us to increase our understanding of human metabolic diseases associated with lipid metabolism dysfunc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Teaching Race, Belonging, Empire and Migration' in the context of a Horizon 2020 call.

assistant: **Objectives**

Issues of race, belonging, empire, and migration have been at the foreground of public consciousness globally in recent years. Our collective understanding of history and culture is often unsurprisingly at the centre of this discourse, with the foundational role of school education coming particularly under pressure. Imparting a full and complete understanding of issues of race and human mobility is in our collective interest, since the resulting diversity and social inclusion generate a range of socio-economic benefits, from increase in innovation and productivity, to the strengthening of social cohesion and racial equality. The present proposal is to use the research undertaken by the ERC-funded project TIDE (681884) to develop TRACTION, a pioneering platform of training, resources, and community network in one place that will equip teachers to engage with issues of race, belonging, empire, and migration in the classroom. Its dual focus on skills-training and community-building is unique, and designed for both immediate and sustainable impact. It is also designed to be modular and expandable, cuts across subject-boundaries, and can be adapted to different national and international educational systems and examination boards. The ultimate aim will be to translate TIDE’s research into a viable and innovative social enterprise that will that remain available beyond the lifetime of ERC funding, with longstanding and far-reaching socio-economic and cultural impact.


**Keywords:** race, diversity, migration, education, school education, teaching, history, literature, professional training, digital platform, social networking, social enterprise