RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Predicting Outcome of Rate or Rhythm Control in Patients with Atrial Fibrillation and Heart Failure' to be submitted under Horizon 2020.

assistant: **Abstract**

Heart failure (HF) and atrial fibrillation (AF) are common co-morbidities (AF-HF). AF-HF is prevalent in Europe with high rates of hospitalisation and death. AF-HF patients have two treatment options: rate control, where AF is not treated but drugs are used to slow the heart rate, or rhythm control, where AF is treated to restore sinus rhythm. Rate control is the first-line treatment, yet specific patient groups do much better under rhythm control. Identifying patients that will do best under rhythm control remains a significant clinical challenge. Potential responders to rhythm control can be identified by their disease history, however, this is often unknown, or their response to treatment, which can only be observed once the therapy has been delivered. We propose to address these challenges by developing patient specific biophysical cardiac models to infer patient history and predict patient response to treatment to inform optimal therapy selection for individual patients.A model for simulating AF-HF in human hearts, representing all four cardiac chambers, will be created. Bayesian uncertainty quantification techniques will be used to combine physical laws, physiology, population data and measurements from individual patients into cardiac models that account for data uncertainty in model parameters and simulation predictions. Patient specific cardiac models will be used to answer three critical clinical questions in prospective studies. Models will be used to predict: if AF led to HF, or HF led to AF in AF-HF patients where the index disease is unknown, response to rhythm control therapy in AF-HF patients and in which AF-HF patient’s rate or rhythm control is best.This proposal outlines an ambitious high risk/return program to address key technical challenges in brin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'REalistic Simulations and ObservationaL Validation of small-scale Energy channels on the Sun' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Sun-like stars possess magnetically confined, upper atmospheres. These coronae have temperatures of several million degrees and thus are much hotter than the underlying stellar surfaces (photospheres) which have temperatures of the order of 6000 degrees. The coronae are hotter than the photospheres because magnetic energy is generated by convective motions beneath the stellar surface and then transported through the photosphere into the corona where it is dissipated. The key to understanding the heating of the corona is to determine how, and at which spatial and temporal scales, energy is being transported into the stellar atmosphere. Both theory and simulations suggest that a substantial fraction of the energy transfer happens at spatial scales smaller than those currently observationally resolvable. The main goal of the proposed research is to bridge this gap between what we expect from theory and what we can observe. The proposed research will use numerical simulations to characterize the energy flux and look for its (spectropolarimetric) signature. This signature will then be used to create maps of the energy flux on the actual Sun using the highest-resolution observations (50-70 km) which are available: those from the 1-meter Sunrise balloon-borne observatory, and the 1.5-meter GREGOR, Europe's largest solar telescope. We will validate the diagnostics by comparing these maps of the observed energy flux into the solar atmosphere with co-spatial observations of the hot plasma structures seen in the upper atmosphere. Understanding the energy transfer combines the strengths of advanced simulations and the unprecedented observations as well as combining the expertise of world-leading solar groups in Germany and Spain. This research will have a major impact on our unders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Thermodynamics of synthetic biological circuits'.

assistant: **Innovation**

The goal of this project will be to create a general theoretical framework to study the non-equilibrium thermodynamics of biological systems with particular focus on synthetic circuits in cell-free environments. To do this, we will rely on the recently developed theory of stochastic thermodynamics, which makes it possible to study the fluctuating thermodynamics of small-scaled systems arbitrary far from equilibrium.Firstly, we will construct a framework to determine the thermodynamic performance of any given synthetic biological circuits. This can be done by breaking the complicated circuits up into specific modules and derive general expressions for the thermodynamic properties of these individual modules. We will first look at cell-free translation-free nucleic-acid networks, and subsequently extend the results to transcription-translation systems and cellular implementations.Secondly, this framework will be used to optimize the thermodynamic performance of some of the most important biologically relevant circuits. We will first focus on simple network motives such as toggle-switches and oscillators, where we will study the optimal network structures leading to the correct behaviour. Subsequently, we will move to more complicated systems such as molecular amplifiers and absolute concentration robust sensors, where we will look at optimal designs, but also derive general trade-off relations between dissipation and robustness.We expect that our results will lead to new design principles for synthetic circuits and give a better understanding of what can and cannot be done using these synthetic networks, but we also believe that our results will lead to a better understanding of the motives behind the evolution of real gene-regulatory networks.


**Keywords:** stochastic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Language birth and language death in a multicultural Context: The Case of Coptic' in the context of a Sixth Framework call.

assistant: **Objectives**

The ways in which languages interact, live and die, in political contexts that impose one or two dominant languages are today a central question for Europe. This project aims to address it through the study of a medieval Middle Eastern society with similar characteristics (multicultural, multilingual, religiously diverse, loosely unified politically, with strong local historical traditions), but remote enough as to enable a dispassionate analysis.The project will focus on the social history of the Coptic language from its birth in the third century to its death around the eleventh century. Linguistically, Coptic is the continuation of ancient Egyptian. It acquired its own identity through attribution of a new social value, association with Christianity, notation in the Greek script, and massive use of Greek vocabulary. For almost a millennium, its interaction with two successive language French (Greek, Arabic) within an evolving historical context yielded varying results, from boosting its status as communal identity marker in times of tension to making it totally obsolete in social terms and leading to its death.I shall study why Coptic evolved in the way it did, how it was used by centres of power, the role it played as a vector of Egyptian identity, and ultimately the reasons for its demise. I shall compare Coptic with the parallel but very different case of Syriac, which arose in similar conditions in the Roman East. The realisation of this interdisciplinary project requires mastery of a number of disciplines and their methods, in the Humanities and the Social Sciences, and competence in numerous ancient and modern languages.It also requires the collaboration of specialists and exceptional documentary resources; such as the University of Oxford is one of the rare es
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Protection of Critical Infrastructures from advanced combined cyber and physical threats' (PRAETORIAN), addressing dissemination and exploitation.

assistant: **Impact**

PRAETORIAN strategic goal is to increase the security and resilience of European CIs, facilitating the coordinated protection of interrelated CI against combined physical and cyber threats. To that end, the project will provide a multidimensional (economical, technological, policy, societal) yet installation-specific toolset comprising: (i) a Physical Situation Awareness system, (ii) a Cyber Situation Awareness system; (iii) a Hybrid Situation Awareness system, which will include digital twins of the infrastructure under protection; and (iv) a Coordinated Response system. The PRAETORIAN toolset will support the security managers of Critical Infrastructures (CI) in their decision making to anticipate and withstand potential cyber, physical or combined security threats to their own infrastructures and other interrelated CIs that could have a severe impact on their performance and/or the security of the population in their vicinity. The project will specifically tackle (i.e. prevent, detect, response and, in case of a declared attack, mitigate) human-made cyber and physical attacks or natural disasters affecting CIs. It will also address how an attack or incident in a specific CI can jeopardise the normal operation of other neighbouring/interrelated CIs, and how to make all of them more resilient, by predicting cascading effects and proposing a unified response among CIs and assisting First Responder teams. PRAETORIAN is a CI-led, user-driven project, which will demonstrate its results in three international pilot clusters –some of them cross border– involving 9 outstanding critical infrastructures: 2 international airports, 2 ports, 3 hospitals and 2 power plants.


**Keywords:** Situation Awareness, Cascading effects, Critical Infrastructure, First Responder, Digital Twi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Glucose variability patterns for precision nutrition in diabetes', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Type 2 diabetes (T2D) has emerged as a global epidemic, impacting 1 in 10 people worldwide and causing over 114,000 deaths annually in Europe. Despite extensive research, understanding the pathogenic mechanisms driving distinct disease subtypes and how diet influences glucose homeostasis has remained elusive. This knowledge gap leaves individuals with or at high risk of T2D without effective prevention or control strategies, urging a paradigm shift in our approach. The GLUCOTYPES project brings together leading experts in nutrition, metabolic diseases, glycobiology, gut microbiome, epidemiology, and machine learning from five European countries to tackle this challenge. Our strategy capitalises on advancements in wearable technologies, molecular biology, and bioinformatics. We propose to leverage high-temporal continuous glucose monitor data to identify patterns of early glycaemic alterations, a concept we refer to as glucotypes and forms the core hypothesis of our research program. Circulating and adipose tissue glycoproteomics profiling will be used to gain molecular insights into glucotypes. Machine learning algorithms will be applied to investigate the intersection between diet and glucotypes on clinical outcomes and gain mechanistic insights into how diet and gut microbiome influence glucose homeostasis in specific glucotypes. The knowledge derived from these activities will inform a proof-of-concept precision nutrition clinical study to test the efficacy of a precision-based diet on cardiometabolic outcomes and identify markers of beneficial responses to diet. In doing so, GLUCOTYPES will come closer to understanding the divergent mechanisms that influence early glycaemic alterations and how specific diets could ameliorate these alterations. Our work will establis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Goniometre a axes de rotation asservis' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

X ray diffraction techniques are used to determine the crystallographic structure of matter. This technique is used in a wide variety of research fields like biology, pharmacology, medicine, solid state physics, and material chemistry. The (purely) mechanical 3-axis goniometers that are currently used have reached their limit of precision, namely the intersection point of the 3 rotation axes can be determined with a precision of at least 3 m. This precision is not accurate enough to maintain the center of a micro-crystal (studied for example by biologists) with respect to that intersection point. Besides, since these instruments cannot account for the effect of gravity, the mass of the sample is limited to about 500 g. We propose to develop a high precision 3 axis goniometer with a precision that should meet the actual requirements of researchers. The originalities of the concept are - the use of high-precision capacitive sensors in order to measure the deformations of the rotation axes caused by gravity; this will allow the electronic control of each axis relative position, and hence a much better precision of the instrument. - the desolidarisation of the fixed frame, which supports the sensors, from the constrained frame which supports the mechanics and the sample to be studied. This new concept should allow - to identify the intersection point of the three rotation axes with a precision less than 1 m. - to study samples with no mass limitation, and especially to use high pressure cells. The realisation of this goniometer will require the development of highly precise capacitive sensors and associated electronics, as well as the fabrication of high precision mechanical assemblies. The main objective of the project is to realise a prototype which will be tested in a sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Atomically thin semiconductors for complementary field effect transistors' (ATOMS) under Horizon Europe.

assistant: **Objectives**

Atomically thin body (ATB) semiconductors such as transition metal dichalcogenides (TMDs) hold tremendous promise for scaling modern electronics because their ultra-thin channel provides excellent gate electrostatics. Major semiconductor companies and international roadmaps for devices and systems have cited ATB TMDs for sub-1-nm semiconductor technologies beyond 2030. ATOMS will focus on developing ultra-scaled complementary field effect transistors (CFETs) based on ATB semiconductors, offering a transformative approach to address the scaling challenges of current semiconductor technology. The project aims to create ultra-short channel CFETs by optimising electrical contacts, developing ideal dielectrics, and integrating multiple pristine interfaces into the CFET structure. Key objectives are the development of clean van der Waals contacts for low contact resistance and high ON state current, fabrication of ideal semiconductor/dielectric interfaces for efficient switching, and novel engineering methods to tune the threshold voltages of both n- and p-type FETs. Additionally, the project will focus on synthesis of wafer scale monolayer TMDs, and seamless integration of all these components to achieve high-performance CFETs. By employing industry compatible fabrication processes, the ATOMS project aims to advance these technologies toward practical applications in next generation low-power electronics. This will position CFETs based on ATB semiconductors as a foundational technology for future electronic devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Global and Local Organization of Production' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A defining feature of the global economy is the gradual fragmentation of production across firms andborders, a phenomenon that has been termed outsourcing or global value chains.State-of-the-art empirical economic analysis on value chains has mostly been limited to the study ofaggregate data because there is limited data on actual firm-to-firm linkages in the global economy. Even lessis currently known about which products are typically outsourced, and which workers are affected.This project will change that. I will bring together four unique firm-to-firm datasets on local and global valuechains that will push the research frontier forward in two main directions:- Previous research has shown that economic integration encourages growth. Due to data limitations,however, we know little about the origins of growth, and to what extent the emergence of value chains canexplain the growth response. New theory is needed, where firm-to-firm connections are endogenouslyformed in response to economic integration. I will confront theory with data and directly test whetherintegration facilitates new buyer-supplier relationships and growth.- Previous research has found that economic integration has large negative effects on wages for low-skillworkers. But again, due to data limitations, it is unclear to what extent value chains are responsible for this.Simply put, the impact of outsourcing on wages will depend on which workers are displaced by outsourcing.Until now, researchers have not been able to observe which workers, along with their occupations andskills, that are employed in both the supplying and outsourcing firm. For the first time, this information willbe available, allowing for a rich analysis of labor market effects for different skill groups.GLOBALPROD will inform policym
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Methods for the concentration and detection of adenoviruses and noroviruses in European bathing waters with reference to the revision of the bathing water directive 76/160/EEC' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The Project will provide a procedure for analysis of EU bathing waters for noroviruses and adenoviruses by validated comparisons of methods for processing water samples to achieve the best virus recovery consistent with cost and feasibility of use in routi ne monitoring laboratories. Objectives are (a) compare methods fornorovirus and adenovirus detection in recreational waters (b) derive a combination of concentration and detection techniques to provide a reproducible system of testing bathing waters for th e target viruses (c) furnish scientific evidence to provide support for norovirus and adenovirus testing of environmental samples in respect of their role as the appropriate viral indicator of faecal pollution (c) prepare the technology for Accession State s as part of the development of their environmental and social programmes (d) share technology between laboratories to achieve wider competence in the virological analysis of environmental materials. Detection by PCR and cell culture together with the conc entration procedure will provide a combined technique. PCR products will be sequenced and data analysed to derive strain and serotype information.The work addresses the research objectives of SSP 8.1 task 1.5 directly through relevance to the revision of t he Bathing Water Directive. Inter-Laboratory comparisons and a large field based surveillance Phase are integrated to ensure that the new combined method will have immediate applicability in EU bathing water monitoring. It will be done by 16 Participant La boratories in a unified approach to derive a harmonised combined method to provide credibility for future monitoring regimes give the potential to place a virus parameter on a footing equal to the bacterial indicators. Inclusion of Laboratories representat i