RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'South American population history revisited: multidisciplinary perspectives on the Upper Amazon' (SAPPHIRE).

assistant: **Concept**

The central challenge faced by linguistics is to understand linguistic diversity. Despite influential programmatic studies and sustained interest, many aspects of the evolution of linguistic diversity remain elusive. Yet, the potential value of understanding linguistic diversity is enormous. It could help us uncover specific past events such as migration and historical contact between societies, perhaps even in very deep time and, more generally, it can give us insight into the interaction between ecology and human behaviour and human cognition.This project will answer these challenges by focussing on the Upper Amazon in western South America, an area which forms a unique microcosm of diversity in which several sociohistorical layers of the continental population history are represented. The north and south are extremely diverse, and likely represent very old diversity patterns. Both areas also show signs of local language contact. The central part is dominated by three language families, which represent expansions of these groups into the Upper Amazon at different stages. This microcosm of diversity forms a unparalleled natural laboratory for understanding more about sociological dynamics and the evolution of linguistic diversity. The project will take an innovative multi-disciplinary approach to unearthing the socio-historical dynamics that have led to these various diversity patterns. In order to do so, geographical, socio-historical, and communicative layers of history are reconstructed and systematically compared, achieving a level of synergy between the disciplines hitherto unseen. Interpreting the (mis)matches between these layers allows for a powerful reconstruction of past events, (e.g. migrations, language shift, exogamy, trade), and sheds light on how these s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INCOMING FELLOWSHIPS BIOMEDICINE INSTITUT DE RECERCA VALL D’HEBRON' in the context of a Seventh Framework call.

assistant: **Objectives**

The INCOMED programme promotes 10 postdoctoral fellowships in all areas of biomedicine and clinical medicine at the Research Institute Vall d‘Hebron (IR-HUVH).  This is an incoming mobility programme taht promotes training and career development that complies with the concept of individual trans-national mobility. It is addressed to experienced researchers capable of developing a competitive research project and based on the merit of the candidates.INCOMED will publish two calls offering 5 fellowships in each call. Each fellowship will have a duration of two years. Eligible candidates will be invited for interviews and the will freely decide the research topic, destination and research group. Succesful candidates will be asked to sign an employment contract that follows national legislation in Spain and a set of guidelines of good practice at IR-HUVH. INCOMED fellows will have supervised training in the laboratory of their choice and will have career development via a set of activities that includes direct management of the postdoctoral committee at IR-HUVH, active participation at international meetings and mentoring of PhD students.The expected impact of INCOMED in the the European Research Area is the implementation of a tool that allows experienced researchers to obtain professional training and career development in biomedicine and clinical medicine in a leading European University Hospital and Research Centre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design of metal-stabilized DNA and RNA nanoconstructs potentially applicable in medicine' under Horizon Europe.

assistant: **Concept**

DNA nanotechnology can provide breakthroughs in various fields such as catalysis, nanofabrication, computation, bioimaging, drug delivery or cancer treatment. This approach is based on the idea that if single-stranded DNA sequences are not perfectly complementary, branched-stranded DNAs can be formed, from which complex 2D or 3D structures can be constructed with near-atomic precision by proper sequence design. Although DNA nanomaterials seem to be promising, the biomedical application is significantly challenged by the fact that current DNA - and especially RNA - nanostructures are unstable under physiological conditions, sensitive towards nucleases and oxidative damage as well. Therefore my main goal is to develop more stable DNA nanostructures that can later be used to stabilize vaccines or drug carriers. For this purpose I will use metal-mediated base pairing in addition to the classical Watson-Crick hydrogen base pairing. During the project I will design, purify and analyse oligonucleotides that stabilize silver nanoclusters (AgNCs) in the small size regime with mixed Ag0/AgI composition in order to achieve AgNC-oligonucleotide systems (nanoconstructs), that can remain stable even in the conditions of the human plasma, thus can be used later as vaccines or drug carriers. This approach is beyond state of the art since it was not even mentioned as a possible application of metal-incorporated DNA nanoconstructs in the most recent reviews of the field, although already existing data combined suggests, it could eliminate many of the issues of previous concepts. I will use modern separation, spectroscopy and structure quantification methods, as well as cellular studies, to design and characterise the system that best meets the criteria.


**Keywords:** DNA Origami, Mass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Virtual screening applied to chemogenomics and protein annotation' under Sixth Framework.

assistant: **Concept**

Since the completion of the human and other organisms' genome sequence, many new druggable targets are expected to be identified by structural genomics with the expectation of developing new therapeutics. One of the bottlenecks of this drug discovery process is the difficulties encountered to understand the function of these new proteins. So far, much emphasis has been given to bioinformatics: the genomes are annotated using sequence analysis or structural modelling. However, these methods are not always applicable or relevant.  This proposal suggests to investigate methods derived from chemoinformatics. Specifically, chemogenomics implies that the function of a protein can be derived from the structure of the sets of ligands that bind to it. By comparing the pair-wise similarity of these sets of compounds to random distributions, statistical models can be used to compute scores between pairs of sets. These scores are then used to build chemical relationship maps, i.e., ontology of the ligands. These maps could be used alternatively or complementarily to other classifications to annotate the genomes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A new process for the application of hard coatings to extursion die in the plastic industry.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The project will develop a laser cladding technique for the application of hard tungsten carbide coatings to extrusion die for the plastics industry. Currently, tiles or nibs of sintered tungsten carbide are applied with brazing. Particles of the carbide can dislodge, causing damage to the die. Renewal of the coating is also time consuming and costly in terms of downtime. The most significant advantages will be virtually perfect adherence of the Coating to the under layer, and the ability to simply re-apply a new coating over the top once the old coating has worn. The particular challenge in developing the technique arises from the geometry of extrusion dies, as they have a large number of small holes whose I/D ' s must be sufficiently coated without any compromise over process time and cost. SME proposer CTD is a wear materials specialist active in the design and manufacture of extrusion die for the plastics industry. It's partner BMF is an SME engineering company.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Evolution of T cell reactivity against somatic mutations across human colon cancer stages with single-cell genomics and synthetic T cell specificity screening'.

assistant: **Concept**

Cancers are characterized by the accumulation of somatic mutations in the DNA. The human immune system can detect such mutations in cancers via T cells, which forms an important factor in the activity of clinically used cancer immunotherapies. What challenges our classic view of cancer formation are the recent breakthrough discoveries showing that somatic mutations are ubiquitously found in healthy tissues - why only some of these mutations lead to clonal outgrowths and what are the factors sustaining them? As T cells recognizing somatic mutations are abundant in cancer, it is plausible to speculate these interactions could start early in tumor evolution. Albeit of high interest, studying this phenomenon has been technically challenging as it requires the ability to obtain mutational data at single-cell resolution and interrogating T cell specificities.The T-REaCT action aims to experimentally map the co-evolution of T cells and cells carrying somatic mutations across tumor evolution. By combining two novel sets of tools and expertise from two competitive fields of synthetic T cell reactivity screening (mentor Dr Schumacher, Netherlands Cancer Institute, the Netherlands) with single-cell genomics (co-mentor Dr Landau, Weill Cornell Medicine and New York Genome Center, the US), we will create a roadmap of immune responses in human colon samples ranging from healthy tissue to adenomas to overt cancer.By describing the formation of T cell reactivity against somatic mutations from pre-malignant to the earliest steps of malignant seeding, our project has the potential to revolutionize early cancer detection and the eradication of (pre-)malignant lesions through personalized immunotherapies.


**Keywords:** TCR, TCR specificity, cancer immunology, single-cell genomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fundamental nuclear properties measured with laser spectroscopy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The prime research theme of this project is the study of short-lived exotic nuclei with laser spectroscopy. Over the next 5 years my team will study the role of three-nucleon forces and their associated influence on nuclear structure and the limits of nuclear existence. This work will investigate the interplay between tensor and central forces and the associated effect on quantum shells in exotic nuclear systems. This proposal will study how the shape of the nucleus is modified at the limits of nuclear existence. We will use innovative laser spectroscopy methods to achieve these goals. The project will be carried out at the ISOLDE facility, CERN, which is the premier radioactive beam facility at the precision frontier. The proposed research activity closely matches the NuPECC (Nuclear Physics European Collaboration Committee) 2010 Long Range Plan. The wider scientific impact of this research will influence modelling explosive stellar processes and nuclear synthesis, understanding the structure of astrophysical compact-objects such as neutron stars and predicting regions of enhanced stability in the super heavy elements. The FNPMLS project will develop ultra-sensitive methodologies that set a new paradigm in laser spectroscopy. It builds on the cutting edge technology of collinear resonance ionization spectroscopy (CRIS) that I have developed during my STFC Advanced Fellowship.  The CRIS technique combines the high resolution nature of collinear laser spectroscopy with the high sensitivity of resonance ionization spectroscopy. The research programme and investment outlined in this proposal will place my team in a unique and world leading position. This work will happen in advance of the next generation of radioactive beam facility such as SPIRAL2, FAIR and FRIB and will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The association between type 2 diabetes diagnosis and diabetes medications with risk of cancer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Type 2 diabetes and cancer are two chronic diseases that negatively influence the survival of millions of people worldwide. Diabetes has been shown in meta-analyses to be associated with an increased risk of several cancers, but these associations are not yet documented as causal. The evidence for specific diabetes drugs affecting cancer risk is limited, because randomized clinical trials are not designed to evaluate specifically cancer outcomes, and observational studies are often confounded by indications for specific drugs. We propose to better characterize the degree of involvement of type 2 diabetes diagnosis and pharmacologic treatment in cancer initiation or progression. Therefore, we will a) evaluate bias and credibility in the existing meta-analyses of diabetes diagnosis and cancer risk, b) determine whether diabetes diagnosis is associated with risk of prostate cancer using the European Prospective Investigation into Cancer and Nutrition cohort, c) perform a systematic review and meta-analysis of randomized clinical trials and observational studies that have evaluated the association  between diabetes medications and cancer risk, and d) evaluate the association between diabetes drugs and cancer risk (separately by site) using the UK-based General Practice Research Database. Cutting-edge evidence synthesis methods (Harbord’s test, excess significance bias test, credibility ceilings) will be used in our first aim, and summary meta-analytic estimates will be calculated in our third aim using random effects models. An incident diabetes drug cohort design with adherence-adjusted intention-to-treat style of analysis will be used in aim 4, while Cox proportional hazards models will be used in both aims 2 and 4. The proposed project will have major impact in the field
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Translating disease to cardiovascular health'.

assistant: **Innovation**

Cardiovascular disease (CVD) is the leading cause of death in Europe and the world. Drugs that lower cholesterol in blood are the most efficient drugs used to date but we are currently still facing a 50-70% residual risk of suffering from CVD. This clearly illustrates an urgent need for the identification, characterization and validation of novel therapeutically relevant targets. Over the last decade, numerous targets have emerged but not led to successful treatment of patients. In addition to missing opportunities of health improvement beyond statins, the 92% failure rate of novel drugs also puts a large burden on the EU economy.While the causal relation between levels of lipids in plasma and CVD forms the basis of this proposal, the challenge taken up by TransCard is ‘Translating disease into Cardiovascular health’: It means that insight into the molecular origin of disturbed lipid metabolism in patients as well as the identification of lipoprotein phenotypes with causal relationships to atherosclerosis can provide immediate targets for pharmaceutical intervention leading to successful treatment of this disease.TransCard will prioritize existing and emerging targets and embark on novel unbiased approaches to identify and prioritize novel key regulators of lipid and lipoprotein metabolism. Achieving this aim will be ensured by a multidisciplinary research consortium of two SMEs and four academic partners who use innovative biotechnological and bioinformatics tools and have direct access to unique biobanks and large-scale population cohorts. This team will also help to translate the  basic insight into biology into clinical use by subjecting promising targets from top level basic research to validation of their CVD association in large prospective and patient cohorts. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Encouraging a digital and Green transition through Revitalized and Inclusive Union-Employer Negotiations'.

assistant: **Concept**

The EGRUiEN project aims to answer the question of how best to ensure a just green and digital transition through social dialogue institutions and practices, to protect, represent and include precarious and non-standard workers, and to protect affected workers currently in primary labour market jobs from falling into precarity.  Europe is undergoing a period of rapid, fundamental transition, which is affecting production, employment, job design and skill requirements in many industries, such as in the sector cases EGRUiEN investigates,  automotive, energy, on-demand transportation/taxi, and care services. This presents contradictory goals: for economic and environmental reasons the transition must occur as quickly as possible, yet this fuels processes of creative destruction that undermines the efficacy of social dialogue.  Social dialogue, however, has often been a tool to guide transitions. EGRUiEN  will research how past social dialogues have managed similar transitions, and how current social dialogues are faring. Through  participatory action research with actual and potential social partners, EGRUiEN will create a research basis to revitalize social dialogue to manage the green and digital transition.  This will  providing us with research-based tools for more inclusive and effective social dialogue. EGRUiEN has nine work-packages: Management (WP1), history (local longitudinal historical case studies, WP2), four sectoral studies (autos, energy, care, and on-demand transport, WP3-6), EU-level coordination (action research, WP7), New Social Dialogue (cross-country analysis, WP8), and Dissemination (WP9).  The historical research provides a basis for the sectoral studies, which provide a basis for EU-level participatory action research (WP7) and cross-national analys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New ground glass process' (NGGP) under Fifth Framework.

assistant: **Objectives**

The production of ground glass (or frosted or etched glass) is linked to heavy environmental impacts and poor working conditions. The etching based process using fluoric acid (HF) leads to polluting effluent wastes and to severe health-threat towards workers. Environment regulations and health and safety rules are not often fully respected by manufacturers. It is found to be too costly to applied especially because of the competitiveness with low-wages labor costs countries that have much less regulations.The objective of the project is to replace the etching process with a cost effective green process. The research goal is to create the surface defaults that produced the ground effect by depositing a coating layer (ceramic type in aqueous formulation) on the glass capable of resisting up to 600°C.