RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chromatin Dynamics of Stem Cells and Lineage Commitment in Plant Development', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In recent years chromatin has emerged as an extremely dynamic platform for establishing and maintaining gene expression programs. Chemical alterations of DNA and histone proteins, nucleosome positioning and histone variant usage collectively allow the formation of complex combinatorial codes of chromatin modifications that determine local DNA accessibility to transcription and transcript processing machineries.As in animals, plant stem cell identity and lineage commitment are controlled by unique transcription factor networks and conserved chromatin factors including nucleosome remodelers, histone variants and histone modifiers of the Polycomb group (PcG, epigenetic repressors) as well as Trithorax group (TrxG, epigenetic activators). Moreover, in stem cells the histone variant H2A.Z collaborates with PcG factors and is pivotal for timely activation of differentiation genes during the transition to lineage commitment.Although more of these tantalizing concepts in the plant and animal chromatin field have recently surfaced non have hitherto been proven in vivo by studying specific cell types derived from developing organisms.I believe plants can become the next stepping-stone in our understanding of these developmental chromatin concepts. Due to lack of cell migration, easy supply of in vivo derived material as well as extensive collections of genetic backgrounds plants offer a unparalleled opportunity to study cell type specific chromatin changes along the trajectory of cell lineage commitment. I here propose to use Arabidopsis root development as a model system in combination with fluorescence assisted cell sorting, chromatin immuno-precipitation and genome-wide analysis of a set of chromatin parameters. This unique study will reveal parallels and diverging concepts of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'a Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment' (FAITH) targeting Horizon 2020.

assistant: **Abstract**

The main aim of FAITH is to apply the latest Artificial Intelligence (AI) and Big Data analytics techniques to better model and predict disease/treatment trajectories of cancer patients, with the goal of improving their quality of life and aftercare. To protect privacy of the individual, but still gain insights that are beneficial to the broader population, FAITH will be applying the concept of federated machine learning, which makes it possible to build machine learning systems without direct access to personal treatment data that will be used for training in machine learning. Devices private to the patient will run their own personalised AI models, via the project’s ‘AI Angel’ application, while a global AI model aggregates the individual model learnings (rather than the traditional approach of a central repository of holding all private patient data). FAITH’s ‘AI Angel’ will remotely analyse depression markers, predicting negative trends in their disease trajectory, giving their healthcare providers advanced warnings to allow for timely intervention. These markers are treated under several distinct categories: Activity, Outlook, Sleep, and Appetite, in accordance with the 3M strategy for population health: Monitor–Measure–Manage. Central to the vision of the FAITH project is to measure population health deeply, it is necessary to monitor individuals on a continuous basis to cast a wide enough net over a user’s health data. A key strength of FAITH is the involvement of eminent cancer hospitals and specialists in the consortium to provide relevant applicable cancer care related use cases that can effectively leverage a big data framework using computational intelligence approaches and methodologies that can be used for long term cancer care health risk and symptom mini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Targeting Mfrn2 to Inhibit Metastatic Cancers'.

assistant: **Innovation**

Metastasis formation is the leading cause of death in cancer patients. Thus, there is an unmet need for drugs that can prevent and/or treat systemic metastases. We have discovered that breast cancer cells rely on a solute carrier (SLC) transporter for metastasis formation in lung and liver. Interestingly, systemic inhibition of this SLC transporter using a therapeutic modality has likely a favorable toxicity profile because knockout mice are viable and have very few and minor phenotypic changes. Therefore, wehypothesize that targeting the SLC transporter can be exploited to inhibit metastatic growth. To valorize this SLC transporter as a drug target, we will 1. Perform a detailed mechanistic analysis of its function in samples from breast cancer patients; 2. Define the efficacy profile of the inhibition of this SLC transporter against systemic metastasis in mouse models; 3. Translate the SLC transporter inhibitionbeyond breast cancer; 4. Determine the efficacy and safety of targeting metastatic patient-derivedxenograft (PDX) with anti-sense oligonucleotides (ASOs) against this SLC transporter and 5. Delineate a strategy to define small molecule inhibitors against the SLC transporter. To do so, we will apply multiplex immunohistochemistry in samples from breast cancer patients and perform state-of-the-art metastasis assays in allograft, xenograft and PDX mouse models. Thus, we will deliver a comprehensive evaluation of the SLC transporter as drug target for treating metastases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Physiological, morphological and neurochemical studies of the cortico-spinal pathway in experimental hepatic encephalopathy' (CST-IN-HE).

assistant: **Innovation**

Hepatic Encephalopathy (HE) A is a neuropsychiatric syndrome occurring in both acute and chronic liver failure that includes behavioural, mental and motor disturbances. The more typical motor abnormalities observed are flapping tremor or cortico- spinal signs (exaggerated deep tendon reflexes, Babinski's signs). Those abnormalities significantly diminish the quality of life of the patients.  Clinical studies led by the host of this fellowship have suggested that a low grade brain oedema along the glutamatergic cortiCOspinal tract (CST) is responsible for the abnormal cortico-spinal functions observed in patients with chronic liver disease. Thus we propose to study the physiological, morphological and neurochemical changes that occur in the CST of an experimental model of chronic liver failure and try to correlate them with brain oedema. We will use immunohistochemical, electrophysiological and microdialysis techniques to assess the effect of chronic liver failure on: (1) the integrity of the cortico-spinal neurons  (2) the degree of myelination of the CST;  (3) the levels of expression of the glial and neuronal glutamate transporters and ionotropic receptors at different levels of the CST;  (4) the release of glutamate upon electrostimulation in the motor cortex and in the spinal cord (5) the cortico-spinal function.  Finally we will try link the electrophysiologic abnormalities to the brain oedema of the CST by using an oedema-lowering therapy.   This project will help of a young French researcher who did his PhD in Canada, to come back to Europe and to complete his training. It will also allow the transfer to the host of the technical knowledge he acquired there. Also the risk of chronic liver diseases is increasing in Europe and is already high in upcoming new member
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'THE ROLE OF TRADITIONAL VOCAL STYLES IN RESHAPING CULTURAL IDENTITIES RELATED TO AFRICAN DIASPORAS IN AMERICA AND EUROPE' (ROTVOSCIAME).

assistant: **Innovation**

The voice, especially the singing voice, is a vehicle of a complex variety of messages. Not all these messages are related to the languages itself, many of them relay a more articulated heritage. In particular, vocal styles developed within the boundaries of African Diasporas go back to the African origin and African vocal traditions. So that, the singing voice could be considered as the place where the connection still exists and is operating (Zumthor). Nevertheless, the connection – as well as the vocal styles themselves – is evolving by passing through new contexts, new social relationships, new forms of religion, new technologies, etc.The effort of vocal performers and composers is both to overcome voice's limits and to go back to ancient vocal techniques. Research will focus on how much performances of contemporary African-American vocal styles – from different musical genres – influence (and express) the reshaping of a new cultural identity. The project will deal at the same time with musicians of a more recent African Diaspora in Europe, where new cultural identities are evolving.Archives will be investigated in order to trace the history of the development of African related vocal styles in the African-American culture. However, a fundamental source will be interviewing professional musicians. During the return phase, professional musicians with African origins who are operating in Italy nowadays will be interviewed. Besides, the contemporary philosophical approach (such as the pioneer study of Adriana Cavarero on social and political function of the voices) will be used, as well as linguistic analyses, in order to enlighten the role of vocal styles in negotiating cultural identities.In addition to academic outcomes, research will implement a map of the performe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next Generation Polymyxin Antibiotics: Optimization and Validation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In the NOVA ERC PoC project, we present a novel class of semi-synthetic polymyxins as an innovative solution to address the inherent toxicity of the polymyxins family of antibiotics. We here disclose the first candidate compounds of this novel family of antibiotics with potential for use as front-line treatment for multi-drug-resistant Gram-negative bacterial infections.Due to antimicrobial resistance (AMR), a resurgence in the use of polymyxin antibiotics has occurred over the last decade, despite the well characterised and dose-limiting nephrotoxicity associated with these compounds. Though designated as last-resort antibiotics due to these side effects, the ongoing rise of AMR is forcing clinicians to rely on unsafe antibiotics such as the polymyxins. Increased polymyxin use results in risks for patients and pressure on healthcare systems.Our novel semi-synthetic polymyxins have best-in-class potential given their significantly improved safety profile and offer a superior alternative to current last-resort anti-Gram-negative antibiotics.  Succinctly, the next generation polymyxins we have developed offer key advantages over current last-resort antibiotics: (i) reduced nephrotoxic side effects, (ii) effectiveness against multi-resistant strains with negligible resistance induction, and (iii) ability to be produced at low cost. Moreover, our robust semisynthetic approach will allow us to generate additional analogues in the future.In NOVA, we will explore the technical and commercial potential of our next generation polymyxins. Specifically, we will validate the first candidate compounds and perform preliminary preclinical toxicity studies in vivo. In parallel, we will evaluate the commercial feasibility of the next generation polymyxins. This entails analysing the mar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a control system for solar thermal installations' to be submitted under Fourth Framework.

assistant: **Abstract**

The proposed research project is to develop a low-cost system for integration in a single unit the regulation and monitoring of solar heating systems, with the aim of avoiding the present duplication of components. The system must be capable of monitoring the solar installation so as to enable performance guarantee methods to be used in small solar installations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Methods for high-throughput (HTP) analysis of protein glycosylation' (HTP) under Seventh Framework.

assistant: **Objectives**

Glycosylation is a post-translational modification that enriches protein complexity and function. Dysregulation of glycosylation is associated with a wide range of diseases, including cancer, diabetes, as well as congenital, cardiovascular, immunological and infectious disorders. A number of studies identified potentially important glycan disease biomarkers. With regard to biotechnology, proper glycosylation of biologicals is important, as deviations in glycosylation are known to be associated with adverse drug reactions and reduced therapeutic efficacy. However, glycomics is significantly lagging behind genomics and proteomics, mainly due to the absence of high-throughput analytical methods which can reliably quantify a multitude of glycan structures in complex biological samples.We are confident that by coordinated efforts of leading European scientists in glycan analysis using HPLC, MS and CGE-LIF technologies this project will make a decisive step forward by developing real high-throughput tools for glycosylation analysis. By teaming up with leading European researchers in the field of genome wide association studies this project will perform validation of all methods on extremely well characterized set of samples resulting from the FP6 EuroSpan project. The addition of the newly generated glycome data to the pre-existing information about these individuals will enable development of methods for the systems biology approach analysis of the glycome which will integrate glycomic, genomic and environmental data about thousands of individuals. The same methods will also be adapted for quality control and monitoring in the production of biopharmaceuticals.Strong participation of SMEs in the project and close contacts with large industrial partners will ensure that resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Effect of Media Multitasking on Online Prosocial and Antisocial Behavior' (MULTIPLE) under Horizon Europe.

assistant: **Objectives**

Digital devices and portable media platforms have become integral parts of people's lives, causing an increase in online activities and an inclination for simultaneous consumption of different media (known as media multitasking, a.k.a MMT). Extant research suggested that MMT causes cognitive strain and emotions and influences an individual’s information processing abilities, likely influencing one’s online social behavior (OSB) (pro and antisocial). Project MULTIPLE examines how multiple dimensions (task hierarchy, emotional content of the task, and time pressure) of MMT activities may influence emerging adults' engagement in OSB. It aims to determine how changes in task hierarchy and the emotional content of the tasks affect individuals’ engagement in OSB. Whether the inclusion of time pressure in the interaction of task hierarchy and the emotional content influences individuals’ engagement in OSB. Other goals are to identify the underlying mechanisms (i.e., mediators, e.g., frustration, cognitive load) and moderators (e.g., tendency to express online, impulsivity) to understand the said relationship.  The methodology integrates eye movement tracking, controlled computer-based laboratory experiments, and questionnaires. The IRTIS Dept. at the MU leads in the media and cyber-related studies and will help the researcher with the team’s state-of-the-art infrastructure. The project will create a cross-discipline theoretical framework (information and communication, cognition and media) and help generate guidelines for improving the work environment in organizations where MMT is prevalent.


**Keywords:** Media multitasking, online prosocial behavior, online antisocial behavior, experiment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Institut Pasteur International Docotal Program' (PASTEURDOC).

assistant: **Innovation**

PASTEURDOC is an advanced educational and research program, hosted by the Institut Pasteur in Paris. Its goal is to train junior investigators possessing medical and/or scientific educational backgrounds to become future leaders in academic education and research institutions, international organizations, private companies, or administration. PASTEURDOC is intended to co-fund and advance the already well-established and very successful Pasteur Paris University International Doctoral Program, in operation since 2009 in partnership with three renowned Parisian universities. PASTEURDOC will enhance the host capacity to train young researchers, while strengthening the Marie Skłodowska-Curie Actions recommendations for professional development of early-stage researchers. The PASTEURDOC objectives are the following:1) To provide the highest scientific education by proposing a large panoply of multidisciplinary research projects and scientific approaches. These will encompass an array of biomedical research fields crucial for human health, and lead to an internationally recognized Doctorate diploma. 2) To provide an exceptional nurturing environment combining practical research, scientific and transferrable skills training and educational follow up, by a well established Teaching Department running and International Doctoral Program. 3) To provide the early-stage researchers with a large international and multicultural network of fellows and institutions, in both developed and developing countries, and within the academic and the private sectors. 4) Two calls will be launched during the 60 months program, in order to train 30 early-stage researchers, recruited for 36 months. PASTEURDOC will significantly enhance the international visibility and the training capacity of the Pas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improved Building Integration of PV by using Thin Film Modules in CIS Technology (BIPV-CIS)' in the context of a Sixth Framework call.

assistant: **Objectives**

The results of the project will improve and widen the potential for the integration of solar (PV) energy systems into existing buildings. Special attention will be paid architectural and aesthetic questions. Building integration of PV systems in most cases leads to a high tech" and "modern" appearance of the building. This is caused by the typical window-like surface of most conventional PV modules. Regarding however that90% of the building stock consists of longer existing, that means "old fashioned" buildings, it is evident that anaesthetically satisfying building integration of PV needs a lot of good will and creativity from planners and architects. In many existing building integrated PV systems the modules contrast with the building and its surroundings. A European survey on the potential and needs for building integrated PV components and systems will identify the basis for the development of modules away from the glass / window-like appearance. In the project PV roof tiles, overhead glazing and facade elements based on CIS thin film technology will be developed and investigated which have a modified optical appearance for better adaptation to the building skin. One of the ideas is optical decoupling of substrate and cover glass. A complete roof tile system with thin film cells adapted to the visual appearance of conventional roof tiles and innovative connection and mounting will be developed. The work includes prototype fabrication and tests according to relevant standards and subsequent performance tests. Novel overhead glazing includes semitransparent thin film modules optimised for daylight transmission. The backside appearance will be modified in order to represent the visible inner part of the building skin. For overhead and insolating glazing an invisible i