RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterisation of mitochondrial proteins in brain' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Mitochondria play an essential role in controlling normal cellular bioenergetics, however, the mitochondrial theory of ageing suggests that these organelles may be detrimental due to excessive production of reactive oxygen species. In addition, under certain conditions, mitochondria control the process of cell death by releasing pro-apoptotic proteins into the cytosol.A large collection of proteins in mitochondria contribute to the normal/abnormal functioning of these organelles which in turn has important implications for a number of human diseases such as age-related diseases such as Parkinson's disease, Alzheimer's disease and cancer. A number of functional differences are known to be present in mitochondria from different organ/tissue sources, however, until now no one has performed a comprehensive proteomics analysis of mitochondria from different brain regions and different neuronal localisations.In the Department of Biochemistry, Trinity College Dublin, there already exists a nucleus of mitochondrial and neurodegenerative researchers as well as recently established proteomics and imaging facilities. However, experienced researchers with expertise in all of these areas are lacking, therefore, this proposal describes a plan to transfer knowledge from experts in the proteomics field to experts in the mitochondria field in Trinity College Dublin. In return, the Marie Curie Research fellows will receive intensive training in the area of bioenergetics and neurodegenerative diseases.An immediate outcome will be the generation of important information concerning the nature of mitochondrial proteins and their relationship to ageing and age-related diseases. Finally, the establishment of a ToK network will allow for transfer of knowledge from European centers of excellence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Climate-Carbon Interactions in the Current Century' to be submitted under Horizon 2020.

assistant: **Abstract**

4C addresses the crucial knowledge gap in the climate sensitivity to carbon dioxide emissions, by reducing uncertainty in our quantitative understanding of carbon-climate interactions and feedbacks. This will be achieved through innovative integration of models and observations, providing new constraints on modelled carbon-climate interactions and climate projections, and supporting IPCC assessments and policy objectives. To meet this objective, 4C will (a) provide a step change in our ability to quantify the key processes regulating the coupled carbon-climate system, (b) use observational constraints and improved processes understanding to provide multi-model near-term predictions and long-term projections of the climate in response to anthropogenic emissions, and (c) deliver policy-relevant carbon dioxide emission pathways consistent with the UNFCCC Paris Agreement (PA) goals.  To achieve its goals, 4C will develop and use: state-of-the-art Earth System Models (ESMs) including biogeochemical processes not included in previous IPCC reports; novel observations to constrain the contemporary carbon cycle and its natural variability; ESM-based decadal predictions including carbon-climate feedbacks and novel initialisation methods; novel emergent constraints and weighting methods to reduce uncertainty in carbon cycle and climate projections; and novel climate scenarios following adaptive CO2 emission pathways. 4C will support two central elements of the PA. First, the PA global stocktakes, by providing policy-relevant predictions of atmospheric CO2 and climate in response to the national determined contributions. Second, the PA ambitions to keep global warming well below 2°C, by providing robust estimates of the remaining carbon budgets and available pathways. 4C will bring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Knowledge transfer for digitisation of cultural and scientific heritage in Bulgaria' (KT-DIGICULT-BG).

assistant: **Concept**

On-line presence of information is closely related to the 'voice' of different cultures in theglobal information society. On the current European scene, where cultural differences andsimilarities are playing a key role in the integration of the Old contine nt, this process is ofspecial importance. Information technologies have offered cultural institutions enormousopportunities for presentation and access to various resources using Internet, but this cannotbe claimed for cultural heritage collections in Bulg aria. They still cannot be widely accessed inelectronic form, and expertise of those working in the field is fragmented.This project is structured as two-phase development scheme. In the knowledge acquisitionphase, it envisages 36 person-months for acquiri ng state-of the-art knowledge in digitisationof cultural and scientific heritage, including general methodology, digital imaging, text corporaannotation, cataloguing systems and web publishing. The following partners of high expertisein the mentioned speci fic fields will support this process: Charles University Prague, TrinityCollege Dublin, Copenhagen University, and NCSR Demokritos" in Athens.The second phase, knowledge transfer envisages 48 person-months for visits to the host. It isstructured in two st eps: direct guidance, and consolidation of the transferred knowledge sothat the host institution starts serving as a national digitisation centre in Bulgaria.The basic impact of this project would be that current fragmented local knowledge will beintegrate d and thus will not only support Bulgarian digitisation endeavours, but will serve as amodel of a holistic approach.Additional outcome of the project will be in filling a currently existing gap in the Europeane-space where Slavonic cultural heritage is pre se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional and synaptic deficits in cerebral cortical neurons in Alzheimer’s Disease model mice' (2007-2013).

assistant: **Innovation**

Alzheimer’s disease (AD) is the most common neurodegenerative disease, affecting millions of people worldwide and therefore it is fundamental to understand its underlying mechanisms. Although the neuropathologies involved in AD are well-described, the effect of those pathologies on neuronal function are poorly understood. Using a transgenic mouse model of AD that overexpresses human amyloid-beta (a-beta), we will study the effects of a-beta accumulation on neocortical synaptic function and receptive field organization using in vivo intracellular recording and in vivo 2-photon laser-scanning microscopy (2PLSM). We will measure the effect of soluble a-beta on individual synapses by imaging calcium dynamics in dendritic spines of somatosensory cortical neurons in response to whisker stimulation. Responses in transgenic animals will be compared to age-matched controls. This will measure the effects of a-beta on individual synapses in vivo. In addition, we will measure the neurotoxic effects of insoluble a-beta plaques on synaptic function by comparing the calcium dynamics in dendritic spines proximal to plaques to those distant from them. Finally, we will measure the effects of soluble a-beta and plaques on the receptive field organization of Layer II/III somatosensory cortical neurons to quantify the effects of the neuropathology on an intact neocortical network. This study will measure and differentiate between the effects of soluble a-beta and insoluble plaques on cortical function at several levels: at the level of the single synapse (calcium dynamics in dendritic spines), single neuron (electrophysiology of subthreshold inputs and spike outputs) and cortical network (receptive field organization) in the intact animal. This study will therefore fill a crucial gap betwee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Creation of a biotechnology cluster network across Europe'.

assistant: **Concept**

The BioRegions network will bring together for the first time, biotechnology clusters across Europe in a network with the key objectives of identifying and addressing issues that affect biotechnology company and cluster development. The network will be dri ven by a Steering Group of the most experienced cluster drivers in Europe, representing Cambridge, Paris, Berlin, Heidelberg, Munich, Uppsala, Oxford, Barcelona, Flanders, Basel, Lyon and Tallin. Key activities to be undertaken within the project include: · Identification of all biotech clusters in Europe and invitation of key drivers to join the BioRegions network · Identification of key issues in biotech and cluster growth and development of activities to address these issues. · Hosting of an Internationa l BioRegions Workshop to debate activities, form projects and consortia and initiate projects across Europe · Hosting of an International BioRegions Conference to showcase the network and its activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LEUKOCYTE MICRODOMAINS AND PLATELET INTERACTIONS IN THROMBO-INFLAMMATORY INJURY' (LEMPIT).

assistant: **Concept**

During the inflammatory response, leukocytes accumulate in the vascular lumen and undergo a morphological and molecular polarization characterized by the formation of discrete domains (a leading edge and an uropod) that allows their directional migration. We aim to understand how and when this polarization originates, as well as the endothelial signals that induce it under physiological conditions. We propose to use a novel intravital microscopy system to image these domains in real-time. Recent observations have shown that leukocytes that are adherent on the endothelium interact with other blood components, including platelets, and that these interactions contribute to the vascular and tissue injuries associated to inflammatory processes. We therefore propose to characterize the subcellular domains and receptors present in polarized leukocytes and platelets that mediate these interactions. We will also investigate the contribution of the interactions mediated by each leukocyte domain (leading edge or uropod) in the normal and pathogenic inflammatory response, using various transgenic mouse lines and different models of inflammation. These studies will allow a better understanding of the inflammatory response at the cellular and molecular levels, and may lead to the rational design of therapies targeting this group of complications that so overwhelmingly threat our quality of life.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'iLoF: AI-augmented photonics to identify and quantify disease biomarkers' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

iLoF is a digital health company pioneering a breakthrough AI-platform to accelerate the future of personalized drug discovery & development. Through advanced AI & photonics, we collect massive amounts of data to build a digital library of biomarkers & biological profiles, bringing together world-class physicists, biologists, & data scientists to get life-saving personalized treatments to patients faster. Our platform captures label-free patterns in biological liquid samples, to generate specific patient or disease signatures. The iLoF device generates multiple highly focused, non-destructive laser beams that interrogate the biological sample to obtain a digital signal of its light pattern. That signal is used to detect modifications providing a flexible & agnostic tool that is not limited to a single use or disease. The current project focuses on developing an Alzheimers disease (AD) clinical trial patient screening tool.


**Keywords:** Alzheimer’s Disease,clinical trials screening,clinical trials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Time-varying metaphotonics via reverse engineering' in the context of a Horizon Europe call.

assistant: **Objectives**

Among the most transformative frontiers in nanophotonics are time-varying materials, whose optical properties can be dynamically modulated on femtosecond to picosecond timescales in response to external stimuli, such as light pulses, enabling ultrafast control over light-matter interactions. These materials hold the promise to enable the next generation of dynamic and tunable metaphotonic devices with reprogrammable functionalities. Transparent conductive oxides belong to this category of materials offering ultrafast refractive index modulation based on carrier refraction and nonlinear effects. Despite the enormous potential of time-varying materials, the design of such systems remains a significant challenge due to the complexity of time-dependent phenomena and the limitations of current reverse engineering (or inverse design) methods, which are predominantly tailored for static systems subject to continuous-wave excitation. To address this gap, TEMPORE will develop novel methodologies of reverse engineering for large-scale, time-varying nanophotonic systems based on the ultrafast refractive index modulation of transparent conductive oxides. Inspired by architectural concepts for modern city planning which need to be adaptable and sustainable, this proposal introduces the concept of “nanoscale cities”: nanophotonic systems designed using architecture-inspired principles to achieve advanced time-dependent and dynamic functionalities. By combining transient material models, pump-probe operation, and highly scalable and efficient solvers on high-performance computing, we will address some of the most pressing challenges in time-varying ultrafast integrated metaphotonics. By unlocking the design and optimization of complex multi-material systems with time-dependent objecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Next Generation Platform as a Service' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cloud innovations have had a major impact on the IT industry but not yet on networks. The danger is that 5G will be a niche industry providing basic connectivity for the cloud applications and services boom. The NGPaaS project envisages 5G as: a build-to-order platform, with components, features and performance tailored to a particular use case; developed through a “Dev-for-Operations” model that extends the IT industry’s DevOps approach to support a multi-sided platform between operators, vendors and verticals; and with revised Operational and Business Support Systems (OSS/BSS) to reflect the new parameters and highly dynamic environment. NGPaaS can enable 5G to become central to a cooperative future with cloud developers, by removing the technological silos between the telco and IT industries. NGPaaS builds on 5G-PPP phase 1 projects and lays the foundation for large-scale phase 3 deployments and industrial usage, through a stepped validation of several Telco, IoT/vertical and combined scenarios culminating in a live test in Paris-Saclay campus that can incorporate innovative SMEs selected for showcasing NGPaaS’s operational, service and business benefits.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Recycling of waste heat through the Application of Nanofluidic ChannelS: Advances in the Conversion of Thermal to Electrical energy' under Horizon 2020.

assistant: **Concept**

Increasing energy consumption, the depletion of natural resources, climate change and decreasing air quality are among the biggest economic and social challenges that we face today. At the same time, waste heat energy discharged into the atmosphere is one of the largest sources of clean, fuel-free and inexpensive energies available, with 70 % of all energy generated on a daily basis being lost as waste heat. Although technologies for converting waste heat into electrical energy have been around for a long time, such as thermoelectric and thermo-electrochemical cells, there is still no environmentally sustainable and efficient technology platform available for the viable harvesting of low-grade waste heat. There is therefore a clear need to develop an energy harvesting and conversion technology which has the potential to exceed the efficiency of current state-of-the-art devices whilst also utilising Earth-abundant materials. The central aim of TRANSLATE is therefore to develop a new proof-of-concept nanofluidic platform technology based on the flux of ions in nanochannels; leading to a breakthrough in versatile and sustainable energy harvesting and storage.Three breakthrough science and technology targets have been identified: 1) optimisation of ion movement and ion separation in nanochannels made from Earth-abundant materials, 2) the development of a sustainable and efficient heat-to-electrical energy platform and 3) the creation of a novel continuous operation energy harvesting power source with a high power/energy density and conversion efficiency.Expertise in materials science, nanofluidics, nanofabrication, thermoelectricity and electrochemistry is integrated on a pan-European level to achieve the overall aim of the project. The knowledge developed in TRANSLATE has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Environmental Regulation and International Investment Strategies' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content:In the discussion out economic globalisation, the issues of liberalising trade and investment are often linked to environmental standards. The project's objective is to provide insight into the forces driving the formulation of strategies in environmental management, especially environmental regulation. The project will undertake an analysis of international management strategies of independent power producers from Germany and the UK in an economic framework by quantitative and qualitative methods.The project will rely on data in the public domain and company data. The results from the project will be valuable to companies, enabling them to anticipate and integrate regulation in their strategies. The project will be relevant to the standardisation of environmental and other regulation across national borders, particularly in the context of increasing harmonisation within the EU. It will inform governments, regulators and companies in developing strategies for sustainable development and enable them to assess the impact of national regulation on companies' international strategy.Training content (objective, benefit and expected impact)The research is for a PhD, to be completed within three years from October 1997. Training contents are research methodology, courses in industrial and regulatory economics and organisational behaviour. The objective is to enable me to start working as a researcher.Links with industry / industrial relevance (22)