RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FATty liver disease and  Gutmicrobial Alcohol Production  (FATGAP)' under Horizon Europe.

assistant: **Concept**

Obesity and subsequent non-alcoholic hepatic steatosis (NAFLD-NASH) are important determinants of morbidity and mortality being imbalanced between ethnicities living in Europe. However, relatively little is known about the underlying aetiology that drives NAFLD-NASH and currently no treatment is available. We and others have mapped alterations in  gut microbiota to metabolic disease, focusing on the bacterial functions. FATGAP builds on our work showing that 40% of obese humans with NAFLD-NASH are characterized by high production of the (endogenous) microbially produced metabolite ethanol derived from mixed acid fermentation of dietary sugars. Our pilot data show that catabolism of the dietary sugar fructose by (small) intestinal  high ethanol producing bacterial strains relates to increased plasma levels of this metabolite. While acidic by-products  of mixed acid fermentation lower intestinal pH thereby inhibiting the ethanol production, proton pump inhibitors (PPIs) increase pH. Indeed, epidemiological data have linked PPI use with NAFLD-NASH. I therefore hypothesize that gut microbial ethanol production from dietary sugar fructose is intestinal pH dependent and is driven by PPI use in humans.  First, I will link gut microbial composition/function  in relation to  impact of endogenous (genetic) and exogenous (medication use) factors in microbial ethanol production with NAFLD-NASH in multiethnic prospective cohorts Second, we will explore how variations in intestinal pH affect kinetics by which (labelled) fructose is catabolized into ethanol and how this process is regulated by (inhibitory) strains and microbially produced metabolites. Third, we aim to culture (CRISPRcas modified) alcohol-degrading bacterial strains which can degrade intestinal ethanol at all pH levels
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Fracton as windows to topology, interaction and constraints in Emerging Phases of Matter'.

assistant: **Objectives**

We propose to study a novel class of quantum phases of matter -- so-called `Fracton' phase of matter, whose quasiparticle excitations, known as sub-dimensional particles, have restricted mobility or kinetic motions. Fracton phases emerge from a rich interplay of correlations, symmetry, topology, and dynamics in strongly interacting many-body systems.  These exotic phases extend and challenge our existing notions of topological order and have attracted broad interdisciplinary interest including topological physics, quantum field theory, gravity, quantum information, and elasticity theory. This proposal aims to build an effective field theory framework to classify, characterize, simulate, and detect distinct fracton phases and search for potential application of fracton for quantum memory and quantum computing both at equilibrium and in dynamical processes. We will apply a multidisciplinary approach combining the latest advances in quantum field theory, quantum information, and condensed matter to design new characterization tools to reveal exotic features of fracton dynamics, explore the microscopic realization of fracton physics and seek new experimental fingerprints to probe these phases. Our research will gravitate around the important question of how dynamical constraints and higher-moment conservation law can engender new types of quantum matter or critical points, and how constraint motion of the quasiparticle can engender robust information storage at intermediate time-scales in quantum many-body systems. We expect the research outcome can expand our understanding of new types of quantum phenomena with constraint dynamics, and shed light for investigating how strong interactions can potentially help identify promising platforms for quantum information storage and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Experimental Research into Ageing' (ERA).

assistant: **Concept**

The diseases of older age are a major challenge to human societies. Despite the complexity of ageing, both reduced food intake (dietary restriction) and simple genetic alterations can greatly increase lifespan and provide broad-spectrum protection against diseases of ageing in laboratory animals. Furthermore, there is strong evolutionary conservation of mechanisms. For instance the nutrient-sensing insulin/IGF and TOR signalling network modulates lifespan in yeast, invertebrates and rodents. There is thus a major scientific opportunity to use model organisms to discover how to ameliorate ageing and hence to protect against ageing-related disease in humans. Our recent findings on dietary amino acid balance in the fruit fly Drosophila imply that consumption of nutrients irrelevant to metabolism is life-shortening. Using a novel genomic approach, we shall determine if the same is true in mice and measure the role of dietary imbalance in extension of lifespan by dietary restriction. Late life dietary restriction in invertebrates can increase future survival as much as permanent restriction, implying that chemical mimetics administered late in life could also be fully effective. We shall determine if dietary restriction in mice has similarly acute effects, and use dietary switches to identify candidate mechanisms of increased health and lifespan.  Recent evidence has pointed to particular components of nutrient-sensing pathways as promising drug targets for prevention of age-related disease, and we shall investigate two candidates. The work will break new ground in understanding how ageing is modulated by diet and signaling pathways and point to interventions that could protect against the effects of ageing to reduce the burden of ageing-related disease in humans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Transformation of Popular Politics in Europe’s Long Nineteenth Century' (TRANSPOP).

assistant: **Concept**

How did ordinary people acquire the capacity to mobilize and influence the political decision-making process? How did standard forms of popular collective action emerge and get institutionalized in European modernity? To address these questions, this project explores the transformation of European popular politics in the long nineteenth-century (c. 1789-1914), while also offering a systematic and empirically rigorous causal account of the processes that led to the emergence of the typical forms of social movement activities that dominate the current landscape of popular protest. The project will seek to address two interconnected problems in current scholarship. First, it will enrich our knowledge of the scope and variety of popular politics in the period by focusing on cases (Hungary, Italy, the Netherlands, and Spain) that unlike the “core” cases of Great Britain and France have not been studied exhaustively.  Second, it will transcend the limitations of existing treatments that have focused predominantly on class formation and state building as the ultimate determinants of popular politics in the period. Through careful archival research and innovative quantitative techniques, the participants will consider an interrelated set of questions on the proper causal relationship between political scale and political mobilization and on the varied cultural and organizational forms of social movement activity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of new innovative functional foods containing microcrystalline chitosan' under Fifth Framework.

assistant: **Concept**

In recent years, the interest in the food sector significantly shifted into the field of functional foods, bearing at the same time interestingly positive nutritional and health effects. Additionally the food industry is intensively searching for new ways economically using the by-products of their production. One of the most promising by-products gained from crustacean shells is Chatoyant, biopolymer, having at the same time promising technical (emulsifier,hydrocolloide) and functional (fat completing, plasma cholesterol lowering, micro-biostatic) properties. Especially in the dairy sector, addition of Chitosanmay solves critical problems concerning the growth of pathogen micro organisms(Wisteria, Salmonella) and improves the properties and the health aspects of the gained products. Additionally, until now in the dairy sector only partly usedbyproducts (e.g. whey proteins) may be the starting point for the development of innovative products with a high nutritional value.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Bioresources For Oliviculture'.

assistant: **Innovation**

The project aims at establishing a multi-lateral network of research and innovation staff active in olive germplasm access, conservation, evaluation and exploitation, strengthening research capacities through the exchange of knowledge and expertise on a shared research programme focused on developing integrated common protocols to phenotype and characterize plants at molecular, morphological and physiological level, and evaluating the olive oil quality related to varieties. The scientific results of the project will contribute at improving the potential of the olive germplasm collections, repositories and banks as main sources of variability and of the evaluation tools to be used to increase oliviculture sustainability. Particular attention will be paid to issues concerned to international intellectual property rights for conserving, exchanging and using the olive genetic resources. Another aim is to create a long lasting network among partners also promoting new common projects in the frame of Horizon2020 and other international funding sources. The joint exchange programme will involve 9 beneficiaries and 6 partners belonging to AC and NAC sectors and will be performed through a series of short and long term staff exchanges and workshops among European (Italy, Spain, Greece and France) and third countries (Morocco, Lebanon, Jordan, Argentina, Chile and Mexico). The International Olive Council (IOC), represented by IOC Executive Director, Jean-Louis Barjol, expressed its strong support to “BeFOre” planning to play an important role in dissemination activities. Experienced and early stage researchers, technicians and managers, are expected to be exchanged between EU and TC to ensure a good scientific transfer of knowledge and training. Enhancement of careers for the sta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Non-invasive and accurate diagnosis and treatment of breast cancer.' to be submitted under Horizon 2020.

assistant: **Abstract**

Increasing evidences indicate that the release of a great numbers of exosomes by tumour cells play a key role in tumour progression, drug resistance, immune surveillance escape, angiogenesis, tumour invasion and metastasis. For this reason, cancer-derived exosomes are emerging as very interesting targets for cancer therapy and diagnosis. In particular, extracellular exosomes may have great potential as early diagnostic and prognostic biomarkers for many types of cancer, including breast cancer. Early screening methods for breast cancer are mainly based on instrumental tests, that may cause in many cases a failure to reach particular categories of patients. This failure could be overcome with the availability of specific and predictive circulating biomarkers allowing non-invasive earliest tumour detection on a larger scale of patients. Indeed, progresses in developing nucleic acids-based therapeutic compounds, including antisense DNAs, aptamers, short interfering/microRNAs, and short activator RNAs, have attracted great interest as emerging platforms for precise cancer treatment. Dr Quintavalle has identified aptamers that specifically recognize BC-released exosomes and are able to discriminate between breast cancer derived exosome and glioma or lung cancer derived exosomes. Preliminary data indicates also that these aptamers are able to block the internalization of MDA231 derived exosome on MDA231 cells. To develop a new diagnostic and therapeutic strategy, Dr Quintavalle will aim to exploit the identified aptamers to design an innovative aptamer-based sandwich assay for their specific detection in patient blood samples. Moreover, since the inhibition of cancer exosome uptake by surrounding healthy tissues and organs would represent an effective strategy to interfere wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quest for novel Multi-functional Oxides: Synthesis, bulk properties, and their microscopic origins' (MULTI-FUNC-MATERIALS).

assistant: **Concept**

A key aspect of current research in transition metal oxides pertains to the ‘multi functionality’ that some of these systems exhibit. In addition to being a playground for discerning the complex interplay of charge, spin and orbital degrees of freedom, these systems hold promise for being the building blocks of the next generation of electronic devices. An important avenue of research is the investigation of systems in which the magnetic and polar orders co-exist; and these orders, both individually and in combination, can be manipulated by the use of external stimuli. Here, we propose the synthesis of two families of transition metal oxides, with the aim for searching for systems with potential magnetoelectric applications. Single crystal growth of these applications would be undertaken to enable sensitive measurements in the spin and charge sectors. These systems would then be investigated using a battery of physical property measurement probes including linear and non-linear magnetization, magnetotransport, and measurements of the dielectric and magnetoelectric susceptibilities. A key aspect would be the use of ‘state of the art’ X-ray and neutron scattering in the presence of combined magnetic and electric fields, to unravel the microscopic origins of the observed phenomenon. The research envisaged is multidisciplinary in nature and holds promise, not only in adding considerably to the current wisdom in this field, but also in enhancing European competence in this technologically important research activity. This proposal on multifunctional materials with tailored properties fits well into one of the main research initiatives of the EU declared in the seventh framework programme, namely ‘Nano-sciences, Nano-technologies, materials and new production technologies’.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Malaria diagnosis and prognosis with an electrokinetic-driven aptamer-based lateral flow assay.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Malaria remains a public health concern, with 247 million cases and 619,000 deaths reported globally in 2021. Despite the increasing prevention and control measures driven by the World Health Organization (WHO), nearly half of the population is still at risk of malaria, with a reported increase in the incidence of imported malaria in European countries. To this end, implementing large-scale, high-coverage, early diagnosis, and accurate prognosis of severe malaria is critical to reducing the impact of malaria in Europe. Due to its high sensitivity, parasite counting by microscopy observation is the current gold standard method. However, it is inappropriate for its application at the point of care (PoC). The rapid diagnostic tests (RDTs) based on lateral flow assay are the best option for PoC testing since they accomplish the REASSURED criteria WHO recommends. However, this method doesn't provide quantitative prognostic information and has proved low clinical sensitivity with low parasitemia samples (asymptomatic parasite carriers). With this aim, I propose for the first time the development of a smartphone-powered electrophoretic-driven aptamer paper-based LFA capable of providing a quantitative measurement of 2 parasite (PfHRP2, pan-pLDH) and 2 host (ang-2 and CRP) malaria biomarkers within minutes. Compared to capillarity-driven LFA, the flow control by electrophoresis enables the application of different synergic strategies to increase assay sensitivity, such as integrated incubation steps and purification of interfering biomolecules. Highly specific aptamers will be developed by a fast and cost-effective microfluidic selection approach, used as bioreceptors with stability for electrokinetics. This will enable an early diagnosis and an accurate prognosis of malaria, r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Impact and viability of a novel mass PCR testing method as a pandemic-fighting strategy' to be submitted under Horizon Europe.

assistant: **Abstract**

The COVID-19 pandemic has not only affected our health, but also our lifestyles and our economies. Given its high non-symptomatic transmissibility, to stop a pandemic-causing pathogen like SARS-CoV-2 early on its tracks without needing to resort to economy-damaging measures, would have required a mass testing strategy very early on: according to some estimates up to 10% of a nation’s population should have been tested on a daily basis to achieve this. Given the exponential growth tendency of pandemic-causing respiratory viruses, as soon as such pathogen is identified a large-scale testing campaign should immediate be deployed (a strategy adopted successfully in very densely populated areas of China). And given the long periods required to develop other pandemic-fighting strategies (i.e. such as vaccines and quick diagnostic tests), PCR-based mass testing could be the ideal front line of defense, since it can be developed in only a few weeks after decoding the genetic map of the pathogen. But although PCR testing capacity has greatly been increased worldwide, regularly testing large fractions of the population would still remain prohibitively costly with current technology.The PCR-4-ALL consortium (combining expertise in diagnostics, high-throughput-screening, virology, disease modelling, econometrics and digital health platforms) will aim to demonstrate the technical feasibility of carrying out population-wide PCR testing by demonstrating a capacity of >10^5 tests in a single day and platform, in an extremely cost-effective manner (at least 2 orders of magnitude cheaper than currently). We will, furthermore, evaluate the effectiveness of utilizing this strategy as the main pandemic-fighting measure by assessing its ability to minimize, or even prevent, the need to imple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Entanglement measures in pilot-wave hydrodynamics' under Horizon 2020.

assistant: **Concept**

A series of ground-braking experiments performed at 2005 showed that millimetric liquid drops can self-propel along the surface of a vibrating fluid bath, by virtue of a resonant interaction with their own wave field. Even more, they demonstrated a version of the famous single-particle diffraction experiment, where one droplet at a time passed through a single or a double slit. The resulting statistical behaviour for successive drops revealed the emergence of wavelike diffraction (single slit) and interference patterns (double slit), a feature previously thought to be exclusive to the microscopic quantum realm. Following investigations established hydrodynamic analogs of many more quantum phenomena with this system, including tunneling, quantized orbits, orbital level splitting, spin states, and more. As of yet, an analog of quantum entanglement remains elusive, but very recent results pave the way in that direction. EnHydro aims to establish entanglement measures in pilot-wave hydrodynamics through experiments with droplets confined to separate wells and their theoretical rationalization.  Experiments to test Bell’s inequalities in this particle-wave-particle system are envisioned as well. Furthermore, physical analogies with quantum entanglement and with theories proposed to rationalize quantum phenomena at the atomic level will be investigated. The originality of this project also lies in its multidisciplinary character and the complementarity of two world-leading research groups in interrelating approaches. It combines a major experimental component using the state-of-the-art set-up available at MIT, with pioneering mathematical algorithms recently developed at ESPCI. The novelty of the proposed research is that it will extend the range of behaviours accessible to c