RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project '3D Printer for Silicon MEMS & NEMS' (2007-2013).

assistant: **Concept**

Additive manufacturing technologies such as 3D printing of polymers and metals have a large impact in many sectors. In this project we propose to explore ways to develop and commercially exploit a new type of 3D printing tool for manufacturing of silicon nanostructures. These 3D printers will make it possible to design and implement silicon micro- and nano-electromechanical system (MEMS&NEMS) sensors and photonic components in low volumes at affordable costs. As a result, resource-intensive semiconductor clean-room infrastructure will no longer be required to design and implement MEMS, NEMS and photonics components. A 3D printer for silicon nanostructures is made possible by employing a novel additive layer-by-layer manufacturing process that has been developed within the ERC Starting Grant project M&M´s (No.277879) lead by the PI. This process is based on alternating steps of chemical vapour deposition (CVD) of silicon and local implantation of gallium ions by focused ion beam (FIB) writing. In a final step, the defined 3D structures are formed by etching the silicon in potassium hydroxide (KOH), where the ion implantation provides the etching selectivity. The feasibility of the technology has been demonstrated within the ERC-M&M´s project by forming 3D silicon structures with layer thicknesses of 40 nm and lateral dimensions as small as 30 nm. To implement a 3D printer that can manufacture 3D silicon nanostructures from computer-generated 3D graphics, the steps of focused ion beam (FIB) writing and silicon deposition have to be combined as a fully automated switched process in a single tool.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Porous Ionic Liquids for Sustainable Energy'.

assistant: **Innovation**

As the societys need for energy is increasing, climate change points towards the need of finding sustainable renewable energy sources. Biogas holds the potential to replace natural gas as energy carrier, thus reducing the reliance on fossil fuels while introducing renewables as drop-in solution to existing infrastructure. However, existing technologies for the removal of carbon dioxide from biogas are energy intensive and considerably decrease the overall efficiency of biomethane as energy carrier. The aim of the project Porous Ionic Liquids for Sustainable Energy (PILSEN) is to improve the energy efficiency of biomethane production from biogas while lowering the carbon footprint. We will achieve this by capturing carbon dioxide during the purification of biogas and using it as a source of carbon. We propose to develop a versatile chemical platform for carbon dioxide removal from biogas, together with the subsequent conversion to value-added chemicals. This chemical platform will be based on porous ionic liquids, which are a new and promising class of materials for processes involving gases. Preliminary results confirm that porous ionic liquids show carbon capture performances similar to benchmark technologies allowing for simultaneous capture and utilization with minimum energy cost. The design flexibility and low environmental impact of ionic liquids bears great potential for the tuneability of our chemical platform. Hence, we will combine theoretical and experimental approaches to identify porous ionic liquids suitable for carbon capture and conversion including the energy-efficient isolation of products.


**Keywords:** carbon capture and utilisation, Biogas upgrading
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DNA MEthylation for HPV-related disease among women living with HIV' (MEsHH) targeting Horizon 2020.

assistant: **Abstract**

Background: The current screening methods for cervical cancer screening among women living with HIV (WLHIV) have previously shown high sensitivity but poor specificity for the detection of high-grade cervical intraepithelial neoplasia (CIN2+), resulting in over-referral for colposcopy and overtreatment of cervical lesions that may have low potential for progression to cancer. Methylation changes of human genes or HPV DNA have been reported early in carcinogenesis but their validation for predicting CIN among WLHIV is lacking. Objectives: Among 1238 WLHIV enrolled in Burkina Faso (BF; n=615) and South Africa (SA; n=623), the MesHH study aims to evaluate the performance of the DNA methylation of human genes (CADM1, MAL, MiR and EPB41L3) and HPV (HPV16/18/31/33) for the detection of prevalent and incident CIN2+ compared to, or in combination with, other screening methods (visual inspection using acetic acid [VIA] or Lugol’s iodine [VILI], cytology and HPV DNA) and to evaluate  the capacity of the DNA methylation markers to distinguish cervical lesion progression, persistence or regression at 16 months follow-up. Methods: The study will use endocervical swabs with matching histological data collected as part of a prospective study evaluating cervical cancer screening strategies among WLHIV in BF and SA. The DNA methylation assays for human genes (CADM1, MAL, MiR, EPB41L3) and HPV (HPV16/18/31/33) will be performed using pyrosequencing assays. Sensitivity, specificity, positive and negative predictive values for the detection of CIN2+ will be estimated for the various DNA methylation markers, as stand-alone or multiplex tests. Relevance: Multiplex DNA methylation assays including a combination of human genes and HPV virus may have potential as primary screening for CIN2+ amo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Leveraging Polymer Therapeutics as Nanomedicine for Local Glioblastoma Immunotherapy' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Research focusing on cancer immunotherapy has provided little progress toward improved survival rates for patients with glioblastoma (GBM), a poorly immunogenic tumor. Clinical trials for GBM immunotherapy primarily focus on the systemic administration of therapeutics; however, they have shown limited therapeutic success. The blood-brain barrier, the tumor immune microenvironment (TIME), the extracellular matrix, the highly invasive/proliferative nature of GBM, and intra- and inter-patient heterogeneity represent challenges to immunotherapy success. Administering polymer therapeutics as a class of biodegradable nanomedicines for localized treatment − a concept I pioneered − represents a less explored area that may fulfill the potential of GBM immunotherapy while reducing doses and adverse systemic effects.GLIOMERS aims to design an immunomodulatory brain-penetrating polymeric drug delivery system that will exploit its intrinsic therapeutic effect by synergizing with conjugated chemotherapeutic agent(s) to directly stimulate antitumor immunity. By encompassing different biomaterials properties, hybrid nanocarriers will be developed using a synthetic microfluidic-assisted approach based on chemically stabilized self-assembled hyaluronic acid – as immunomodulator – with complementary poly-L-lysine to support brain penetration. I will capitalize on the properties of this new class of nanocarriers by conjugating chemotherapeutics re-purposed for immunotherapy. This approach will allow not only the local spread of the drug within the GBM, but also an additional rewiring of immunosuppressive TIME with an enhanced T cell-mediated immune response.GLIOMERS will provide an innovative advance in the design of translational nanomedicines for local brain delivery, contributing to enh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Library and Survey-data Extraction Service' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

ILSES is designed to serve both end-users and content-providers of socio-economic information. For end-users ILSES facilitates the integrated access and retrieval of two different kinds of information:documentary information as is commonly available from libraries;empirical data as archived by data archives. ILSES allows end-users to extend literature research and searches with a focused access to empirical data which can or have been used in empirical research of the kind reported in the literature they review. This allows them to extend classic literature research with their own original empirical analyses of relevant data. ILSES also offers alternatives in directing data analysis and searching for specific empirical data for secondary analysis. For content-providers ILSES offers tools and procedures for the normalisation, cataloguing and controlled distribution of (distributed) holdings of documentary and data resources. ILSES will enable content providers to increase and improve the utilisation of their information resources while at the same time reducing their support burden per information request or retrieval.Technical approachILSES is designed as an open system which can be applied to different kinds of library and data holdings. In this project, however, a pilot application will be focused on socio-economic information as collected by large scale surveys, and on the associated literature. ILSES is based on integrated relational databases of meta-information pertaining to both library and data archive holdings, both of which are typically distributed over many different institutions. In order to productively connect such holdings with each other and with end-users, ILSES provides a wide area network interface utilising Internet and supporting browsing and retri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Identification of low and moderate penetrance genes predisposing to colorectal cancer utilising established and novel biotechnology (NEW COLON CANCER GENES)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Colon cancer is one of the most common malignancies in Europe. To fight this disease understanding the molecular nature of tumorigenesis is essential. Studies on colon cancer susceptibility has contributed greatly to our knowledge on these issues, in part through previous breakthrough discoveries by the participants. The focus of this proposal is on identification of low/moderate penetrance genes predisposing to colon cancer. This goal is of particular importance; not only do we anticipate deriving information on mechanisms of cancer in general, but also information on predisposition alleles affecting a considerable proportion of the population. Such data is a key to more efficient cancer prevention, detection, and treatment. The proposed goal is a demanding one, and an update on the biotechnology utilized is obligatory. This consortium will form a critical mass regarding both extensive sample materials, and competitive technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reconstructing the ecologies of Earth’s earliest arthropods', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

A major goal of palaeontology is having accurate and well-informed reconstructions of the ecology of ancient animals. This is key to our understanding of the broad-scale development of life on Earth and global ecosystems. Arthropods are the most abundant and diverse group of animals throughout Earth’s history, comprising >80% of described species, living across the globe, and displaying a broad range of morphologies that may represent the earliest adaptations to key ecological niches. The RECO-ECO project will test putative ecological adaptations of Earth’s earliest arthropods, clarifying how they dispersed globally and how they moved and fed in these environments >500 million years ago. I will achieve this by refining sophisticated Computational Fluid Dynamics simulations and the novel establishment of flume tank Experimental Fluid Dynamics. RECO-ECO has three Research Objectives: (1) Do morphologies of key extinct arthropods represent adaptations to a pelagic ecology? (2) How do extinct arthropod head shields interact with water and particle flow in feeding? (3) How do arthropod exoskeleton sclerites move and orientate in water and sediment flow regimes? Through answering these questions, I will reveal: (1) whether pelagic ecologies increased the dispersal capability of early arthropods, allowing them to dominate Earth’s oceans; (2) when key feeding ecologies evolved in arthropods and how they shaped ecosystem change; and (3) whether our fossil record palaeoecological interpretations are reliable or impacted by sedimentary flow processes. The need for robust palaeoecological hypothesis-testing is not unique to the arthropod fossil record and so the establishment of reliable and broadly applicable fluid dynamics methods will allow quantitative palaeoecological testing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantification of information flow in a cell signaling pathway' (Cellinfo).

assistant: **Concept**

Signaling pathways are cascades of biochemical reactions that transduce environmental signals to the cell interior. The cells rely on the information transduced through signalling pathways to govern biological functions and maximise the fitness of the organism. Conversely, defects in the signalling pathways are implicated in various diseases, e.g. carcinogenesis. The intricate network of signalling pathways indicates the existence of sophisticated information processing mechanisms, motivating the key questions of this project: How much information is transmitted from the environment through the signalling pathway? How many features of the signals are conveyed? Are signals integrated over time? To answer these questions, the project combines state of the art quantitative optogenetic experiments and theoretical modelling using information theory to quantify the information flow in the canonical MAPK signaling pathway. Experimentally, a well-defined stimulus will be applied at the beginning of the pathway while measuring the response at the end of the signaling cascade. The results will be integrated into a theoretical framework based on statistical physics and information theory to quantify how much static and dynamic information is being transmitted, offering key insights into cell function — the building blocks of living organisms — with potential application in drug design. The strong interdisciplinary nature of this project and the detailed dissemination strategy promotes collaboration between research communities of physicists and biologists, as well as reinforces information as a key concept in life sciences. The included training plan ensures the candidate will acquire skills in advanced experimental and theoretical techniques, and the two-way transfer of knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improving Resilience of Urban Societies through Advanced Technologies' (IRUSAT), addressing dissemination and exploitation.

assistant: **Impact**

Urban societies depend heavily on the proper functioning of infrastructure systems such as electric power, gas, potable water, and transportation networks. Normally invisible, this reliance becomes painfully evident when infrastructure systems fail during disasters. Moreover, because of the network properties of infrastructures, damage in one location can disrupt service in an extensive geographic area. The societal disruption caused by infrastructure failures is therefore disproportionately high in relation to actual physical damage. As a result of the project, new retrofitting strategies will be developed to improve the resilience of infrastructures to withstand natural hazards. The project aims to improve the resiliency of buildings, bridges, and communities in general through new advanced technologies such as base isolations, viscous dampers, etc. Base isolation systems that are able to control the shape of the floor response spectrum will be analyzed, in particular their behavior under vertical excitations. Attention will be given to infrastructural systems’ components and then it will be extended to performance of component assemblages (e.g., bridges, pipeline networks, etc.). The project will range from field work of specific lifeline damage in New Zealand, Japan and Italy after the earthquakes to laboratory simulations done in the laboratory of the University of California at Berkeley with scaled models and numerical analyses. Complexities of infrastructures, which include societal as well as technical issues will be addressed in the project. The project will try to answer through an interdisciplinary approach to the following questions: How, for instance, will the failure of one bridge affect businesses throughout the urban area that rely on the transportation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Trace elements in Food and Reference Materials' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Specific Objectives Method validation:1. To validate 6 methods for stability measurement for various different combinations of trace elements BCR-184 (bovine muscle), BCR-634, 635, 636 (human blood) BCR-279 (sea lettuce), BCR 397 (human hair), VDA1-4 (polythene), BCR 640-642 (human urine), BCR 637-639 (human serum);2. To finalise the method validation for the measurement of radium in drinking water;3. To validate solid sampling methods for the measurement of trace elements in sediment, and an investigation into its possible application for various food matrices;4. Validation of methods involving a new SS-ZAAS instrument;5. To give relevant input into CEN method validation procedures for trace elements in seafood, dietetic food and infant food (e.g. milk powder) applying both in-house and inter-laboratory validation.Method development:6. To develop a method for the measurement of trace metals in sediment and different food materials by ETV- ICP-MS. Anticipated milestones and schedule Ra validation report ready Task completed 2003-10-31 BCR 397 (human hair) Task completed 2003-08-31 VDA1-4 (polythene) Task completed 2003-08-31 BCR-634, 635, 636 (human blood) Task completed 2003-08-31 BCR 637-639 (human serum) Task completed 2003-08-31 SS-ZAAS validated Task completed 2003-10-31 Sediment by ETV- ICP-MS ready Task completed 2003-10-31 BCR-279 (sea lettuce) Task completed 2003-12-31 Trace elements in BCR-184 (bovine muscle) Task completed 2003-12-31 BCR 640-642 (human urine) Task completed 2003-12-31 Planned Deliverables:Validation reports for trace elements in various matrices; 1 validated method/ validation report - radium in drinking water; 1 validated method for measurement of trace elements in sediment by solid sampling; 2 advice to CEN with respect to the applicability