RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Research Training on Supranational Criminal Law' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The last decade has seen a breakthrough in the development of the body of law concerning war crimes, crimes against humanity and genocide. A completely new field of law has emerged: Supranational Criminal Law. Establishment of Supranational Criminal Law jurisdiction will have a stabilising effect on societies and relationships between societies worldwide.The resulting political stability and peace is essential for economic prosperity of the European Union. The basis of current Supranational Criminal Law jurisdiction is a combination of many old law families and traditions. This gives rise to a number of issues, which restrict the authority of it's jurisdiction.For example, there still is disagreement on the details of current definitions, characterisation of crimes and on the concept of Crime of Aggression. A major restraint is that here are only few lawyers/jurists in the world who may be considered to be genuine Supranational Criminal lawyers/jurists.A new generation of lawyers/jurists must be raised for this new field of law. The SUPRA-RT project will produce 168 young top researchers for the European Research Area, newly-trained on Supranational Criminal Law research. The training consist of 4 Top Summer Schools, 8 Research Courses and 2 Network Conferences over a period of 4 years.The training alongside scientists and practitioners with international reputations of relevant disciplines of law, will guarantee broad knowledge and experience on eminent issues within Supranational Criminal Law, giving the selected young top researches a distinct head-start over young researchers pursuing standard single discipline education.They will be extremely valuable for the future of Supranational Criminal Law research within Europe. This will contribute to important Community po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A framework and tools to develop effective quality improvement programs in european healthcare' (REBEQI).

assistant: **Innovation**

Quality improvement (QI) measures aim to improve health services. However, commonly used strategies for QI do not change professional practice or improve patient care. The objective of this proposal is to narrow the gap between research and practice by developing a research-based approach to QI. We will establish a framework for the selection, implementation and evaluation of QI interventions that address identified barriers to change and that can be tailored to local circumstances. Methods to identify the causes of sub-optimal care will be developed and interventions will be designed to address identified problems. Internet-based tools will be developed to help clinicians, policy-makers and others to transfer research findings into clinical practice. Expected results include a suite of tools for identifying barriers to change and a framework for selecting appropriate interventions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'French paradox - red wine extract food additives (PARADOX)' (PARADOX), addressing dissemination and exploitation.

assistant: **Impact**

Europeans dream of dying at the age of over 90 in perfect health."" Food and nutritional habits are playing a key role in public health and quality of life. Functional foods may contribute to healthier nutrition and may prevent diet-mediated disease. The use of plant extracts containing a mixture of secondary plant metabolites offers an effective tool to enrich food, although the knowledge on identity.. stability and efficacy of such extracts is incomplete. BBC news show broadcasted its ""French Paradox"" story in 1991. The authors had travelled to Lyon, France, to interview doctors and hear their explanations of why the French affinity for fatty cheeses, foie gras and indulgently heavy sauces still results in one of the lowest rates of heart disease, much lower than that of Americans or Europeans of regions outside typical wine growing areas. Based on these findings we selected the Acronym PARADOX for our proposal. PARADOX is based on results of large epidemiological studies (known to a wider public as the French PARADOX) and recent in vitro tests,. which have proved the efficacy of the complex mixture of compounds in red wine to prevent cardiovascular disease, Alzheimer's disease and dementia, and have shown potent inhibitory action on prostate and breast cancer cell lines. Extraction, standardisation and formulation of protection agents from red wine are the development targets of the PARADOX project. Commercial application of the product in basic foods is the economical goal. Dissemination will be done to the European Food Industry. Task of PARADOX is to obtain a stable extract from red wine skins and seeds, to identify and quantify the leading compounds analytically, to formulate the extract in stable, palatable preparations and to add it into basic food preparatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synchronic Entanglements and New Social Imaginaries: Anti-War Activism in Brazil and the United Kingdom in the Twenty-First Century' (SENSIAWABUK).

assistant: **Concept**

The project aims to investigate the practices and modes of association of anti-war activists in Brazil and in the UK, while formulating an interaction ritual theory that places emotions and synchronicity at the centre of social process. Building on interaction ritual chains theory (Randall Collins), I articulate a notion of synchronicity that emerges from a theorisation of the relationship between social suffering, creativity, and collective process. In short, I show how actors create novel social form while synchronically entangled with one another. While proposing an innovative multi-method approach for the study of social movements, which relies on biographic interviews, network analysis, and sequence analysis, I aim to illuminate: (1) the relationship between the biographic events of activists, and the events of the movements, thus setting the stage for an eventful sociology of social movements; (2) the structure and dynamics of networks of peace activists, understood as interaction ritual chains, and having as a result particular forms of solidarity; (3) the forms of actorness and political imaginaries of the social movements. This methodology grounds a novel way of construing the relation between micro-events and macro-events; and it allows to observe how the practices of anti-war activists in the past decade rework the boundaries between state and society. In particular, the project contributes to understanding how “war” and “peace” are construed as symbolic objects in contemporary political imaginaries. Anti-war movements are privileged sites of research for studying synchronic entanglements, especially in the aftermath of the 9/11 events, the US response to them, and the revival of pacifist mobilisation that followed.  Brazil and the UK constitute two very diff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a Compact, Time-Efficient and Safe Medical Diagnostics Machine' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Current tissue processors on the market take up to 24 hours to process samples for diagnosis and leave the operator exposed to chemicals. They also use different kinds of chemicals, in large volumes, which leads to cross contamination of chemicals and samples. This results in more plastic packaging to dispose of, making the process both costly and environmental unfriendly. Our company, DIAPATH SpA, is developing an innovative solution to these problems, Origin. DIAPATH has been in the tissue processing industry since 1997 and currently has a turnover of €16.8 Million and 97 employees. Origin reduces the number of processing steps, and reduces the number of chemicals used. The operator will be safeguarded from chemical exposure. Our value proposition is, less operating costs due to reduced chemicals and packaging, faster diagnosis and results for patients. Our target users are Hospitals and Diagnostics Laboratories. The current global diagnostics market is estimated at €243.59 Million and expected to reach €378 Million by year 2025. Our entry point for our innovation will be the European market, where we already have significant market share. We will be using our extensive distribution chain to bring our innovation to international markets. Our innovation is currently at prototype stage with a compact functional machine tested in relevant environment. Further validation and tests remain to be done to bring it to market. This innovation will grow our market share to 30% and increase our turnover to €60million by 2023. It will also create 29 new jobs.


**Keywords:** Cancer Diagnostics, Tissue Processor, Diagnostic Machine, Histopathology, Laboratory Diagnostics, Human Tissue, Tissue Fixative, Pathology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Architectures Software and Hardware for MPEG-4 Systems'.

assistant: **Concept**

The objective of the EMPHASIS project is to firmly establish a European lead in software and silicon technology suitable for meeting the needs of MPEG-4. In the process of doing so, EMPHASIS will play a very active role in the definition of the MPEG-4 standard from an implementation realisation perspective.EMPHASIS will deliver 4 key technologies:MPEG-4 Systems layer (MSDL).- Software implementation of MPEG-4 tools and algorithms.- Audio & Video composition technology.- Specifications for enhancing processor architectures and hardware acceleration modules that meet the multimedia demands of MPEG-4 applications.Real Time Video Decoding of MPEG-4 Video VM on a workstation,Specification of Objects-On-DemandApplications for MPEG-4,Systems and Market analysis,Prototype Video and Audio Compositor implementations,Characterisation and benchmarking of processor and VLSI blocks for MPEG-4 video decoding low level functions,Identification of VLSI acceleration blocks,Software optimisation of key primitives for European processors,Virtual Machine for Multimedia applications analysis,Over 50 contributions to MPEG-4 (including the initiating of a major reduction in Video Decoding computational complexity).Expected Achievements Provision of platforms that meet the demands of real time MPEG-4 A/V decoding.Demonstrating clearly the benefits of MPEG-4 technology to a wide audience.Providing a strong contribution to the MPEG-4 standardisation process, particularly in terms of computational and system complexity reduction.Providing a suite of modular MPEG-4 software components that can be exploited by third party application developers using the demonstrator technology.Tailoring the software technology to extract the maximum performance of the European processors supported by the project.Sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Lean innovative connected vessels' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

LINCOLN presents three new concepts of added-value specialized vessels able to run requested services for several maritime sectors in the most effective, efficient, economic valuable and eco-friendly way. LINCOLN will develop three types of completely new vessels concepts at TRL5, through dynamic simulation model testing. The first is a Multi-platform Catamaran to serve as: Service crew vessel and Multipurpose survey vessel, optimized for Ocean energy and Aquaculture. It will develop a new people transfer system, able to improve safety during people transfer, it will have reduced operations costs and will be eco-friendly. The second is a Module Based High Speed Patrol Boat Platform, that is reconfigurable to adapt to the different operational requirements of Patrol and Security operators. Here LINCOLN will develop one platform, where different vessels can be designed for several markets, built as series production at low cost and it will enable the new “Vessel as a Service” business model. The third one is an Emergency Response and Recovery Vessels series for Coastal Rescue activities, with integrated electronics, IoT connectivity and an enhanced and low cost Integrated Dynamic Position System, which will help rescue operators during their activities and enhancing safety and security. All the three vessels will share the same design methodology. In fact, LINCOLN will be also a success story for the use of innovative design methodologies and tools in the marine sector. It will use: a lean fact based design model approach, which combines real operative data at sea with lean methodology, to support the development and implementation of the vessel concepts; IT customized tools to enable the acquisition and usage of field data, coming from an IoT platform; High Performance C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of the transcription factors oct-6 and krox-24 in development of the cells of the schwann cell lineage' under Fourth Framework.

assistant: **Concept**

Research objectives and content The long term aim is to understand the developmental regulation of differentiation in the Schwann cell lineage. In this project, it is proposed to analyse the role of the POU domain transcription factor, Oct 6/Tst-l/SCIP and the zinc finger transcription factor Krox-24 in the development of Schwann cell precursors and their transition to Schwann cells, and to examine the role of Krox-24 in the maturation of non-myelin-forming Schwann cells. The basic plan is to use techniques developed for the study of normal Schwann cell precursors and Schwann cells to determine how the phenotype of these cells is affected in Oct 6 and Krox-24 knockout mice. In order to get this aims we will study: - The Schwann cell precursor survival behavior in the mutants - The antigenic phenotype of mutant cells (NCAM, Ll, p75NGFr, A5E3, Ran-2, vimentin, nestin and GAP-43 expression). - The progression from precursors to Schwann cells (S100 positive, tri- or bipolar cells that can survive in defined medium when cultured at 2()()() cells/coverslip) in DNRG. - The antigenic profile of Schwann cells from EIG/17/lX mutant nerves and their responses to mitogens such as FGF and anrg. - The survival ability of Schwann cells from mutant nerves in low density culture. - The ability of the Oct 6-- to achieve normal 1:1 segregation and myclinate in co-culture with DRG neurons. - The morphology and axon relationships of precursors and non-myelin cells in developing postnatal nerves in Krox-24 -animals. - The differentiation of non-myelin cells in postnatal nerves of Krox-24 -- mice. Training content (objective, benefit and expected impact) My stay in this laboratory, working with an expert and prestigious group, would be a great opportunity in order to be trained in cell cultur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Nanoscale organization and dynamics of ER-mitochondria contact sites upon induction of synaptic plasticity'.

assistant: **Innovation**

The endoplasmic reticulum (ER) can rapidly reorganize its functional domains and inter-organelle communication sites in response to cellular demands. ER-mitochondria communication is essential for normal cell physiology, as it conveys lipid exchange, mitochondrial calcium uptake, among other vital processes for mitochondrial function. In neurons, activity-mediated dynamics of ER and mitochondria are required for synaptic responsiveness to induction of synaptic plasticity and stimulating neuronal activity increases the number of ER-mitochondria contact sites (ERMCSs). Whilst system modelling predicts that ERMCSs control the postsynaptic energy landscape, the actual contribution of synaptic and perisynaptic inter-organelle dynamics to synaptic plasticity is still quite unknown.The small and compact structure of dendrites constrains the visualization of local ER-mitochondria contact site dynamics, being the application of nanoscopy techniques fundamental to follow these processes upon induction of synaptic plasticity. The use of cutting-edge super-resolution microscopy in this project will provide unprecedented spatiotemporal resolution to the study of activity-mediated ER and mitochondria dynamics and inter-organelle contacts heterogeneity in live neurons. Likewise, it will clarify the contribution of ERMCSs to sustain normal dendritic physiology as well as the intricate system triggering and upholding synaptic plasticity. Dysfunction of the ERMCSs has been reported in various neurodegenerative disorders due to mutation in proteins promoting and supporting ER-mitochondria communication. Neurodegenerative disorders are responsible for a great burden in disease, as dementias alone affect over 7 million people in Europe and this figure is expected to increase dramatically wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Cellular and molecular mechanisms of nicotine dependence'.

assistant: **Objectives**

Tobacco smoking is one of the major preventable causes of morbidity and mortality , as it increases the incidence of lung cancer, pulmonary , respiratory and cardiovascular diseases. Smoking is mainly due to the addictive properties of nicotine, which stimulates neuronal cholinergic-nicotinic receptors (nAChRs ), but insufficient knowledge of the mechanisms underlying this dependence has so far prevented rational anti-smoking interventions. The aim of this project is to extend our knowledge of the mechanisms leading and maintaining tobacco smoking To this end, we will study:a) the nAChR subtypes involved in nicotine addiction in animal models and humans, their functional and pharmacological properties, their sub cellular localization and how nicotine changes their expression and activation using classical neurochemical, molecular and cellular techniques.b ) the long-term effects of nicotine on gene expression, using DNA micro arrays in human cell lines because chronic exposure to addictive drugs leads to long-term changes in gene expression in certain brain structures that may be pathophysiologically relevant in maintaining addiction.c ) how nicotine increases the release of dopamine (DA) in dopaminergic neurons and whether DA plays a role in the acquisition of nicotine dependence.d) the correlations between the molecular and cellular results and behavior by using new rodent models of nicotine addiction to perform behavioral experiments in wild and single or combined alpha7, alpha4, beta2 KO animals;e ) the possible role of genetic determinants in human nicotine addiction by seeking polymorphisms in the promoters of nicotinic subunits in a selected population of smokers and non-smokers.