RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A revolutionary HYDRO POWER technology to sustainably exploit super-low-head water steps'.

assistant: **Innovation**

Energy utilities, investors and project developers are actively looking for decentralized solutions that combine sustainabilitywith stable and risk-free energy production at low cost. Since wind and solar are highly intermittent, hydropower is to take animportant role in the energy mix. An alternative to large dam facilities is small hydropower technologies but they still presentthe major challenge of size reduction in order to lower the usable head (water height) to under 3 meters.All kinds of hydropower techniques have been tried to scale down for local and to lower the usable head to under 3 meters,without success until now.TURBULENT provides a reliable, cost efficient, micro hydropower plant uniquely designed to use a very lowhead stream (<3m) without impact. Based on a biomimicry, the power plant generates energy close to the end user rangingfrom 15kW to 100kW.• No dams= Fish friendliness = Reduction of civil works >50% .• Smaller, lighter, easier installation and maintenance.• Biomimic impeller design = Double energy production with same size• =Cheaper cost-of-energy €0,026/kWh. (Solar is € 0.06kWh)Current TRL is 7. 2 Real scale demonstrators and 1 commercial setting succesfully completed & in operation.MARKET: Global <3m hydropower installation potential of 341GW! This represents a global market opportunity of €1x10^12(1 Billion €).Turbulent is unleashing the potential of micro hydropower and expanding the technology in EU & abroad countries throughtrained and certified distributors (Viral in social media +100M views = +3.5K requests received).The SME project will allow to accelerate the market entry and the company team growth (37 employees by 2023). In 2021the company will reach profitability and the forecast show a cumulative EBITDA in 5 years of €64M.Funding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identification of inflammation pathways involved in the predisposition to decreased neurogenesis and depression' (MECPST-IPD).

assistant: **Innovation**

Current drug therapies for depression have clinical benefits for many patients, however, there remains a large number of patients who either do not become entirely enabled or do not have any clinical benefits whatsoever. Depression is estimated to cost society financially upward of 1% GDP, not to mention the toll on those suffering from depression including their families. During the past decades, enormous resources have been spent to find new mechanisms through which to treat the disease though without any results thus forcing researchers to change strategy. One development has been the general acceptance that depression may be composed of several pathologies rather than a single disease mechanism. In this project we incorporate three potential pathologies which have recently been associated with depression. The first is stress which is known as a common cause of depression followed by adult neurogenesis which has recently been suggested to regulate stress. Finally, inflammation has most recently been suggested to develop into a pathology which can cause depression. Our latest research has shown specifically an association between depressed individuals who are exposed to early life stress and inflammation and furthermore that these exposed individuals have an increased level of inflammation even in the absence of depression. We have therefore developed a hypothesis that individuals exposed to early life stress have an inflammatory predisposition  and have a larger chance of developing depression if other pathologies (stress/decreased neurogenesis) are also present. If this hypothesis is validated, treatment methods targeting this predisposition will be of significant interest.  To test this hypothesis we plan to develop an animal model which incorporates these patholog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biomass heatpipe reformer (BIOHPR)' (BIOHPR).

assistant: **Innovation**

Objectives and problems to be solved:Producing electricity from biomass with gas turbines or fuel cells requires hydrogen rich fuel gases with reasonable high heating values. These heating values are only achievable by means of all thermal gasification or all thermal steam reforming. The BioHPR project aims at the development of an innovative all thermal gasifier concept the 'Biomass Heatpipe Reformer'. The innovative idea of the concept is to apply the heat for the endothermic gasification process to the reformer by means of high temperature heat pipes. The concept promises a particularly small all thermal gasifier that produces hydrogen rich gases for small-scale CHP applications with micro turbines and fuel cells. Key features of the new concept are its simple ness and a flexible heat-to-power ratio, which makes the concept competitive even without adequate heat consumer. Description of work: The project is aimed at the developing, constructing and testing of two 200 kW prototypes of the Heatpipe Reformer. The work will mainly focus on the solution of the main technical challenge for indirectly heated gasifiers - the realization of extremely high heat fluxes into a small sized gasification reactor. The application of heat pipes for this purpose will be tested and demonstrated. The excellent heat transfer characteristics of the heat pipes combined with high heat transfer rates between fluidized bed and heat pipe surface allow to design a very compact, highly integrated apparatus for steam gasification of any kind of biomass. Both prototypes will be tested with wood pellets, straw pellets and pellets produced from cotton stalk residues. Long-term experiments (72 hours) are planned to test the long-term stability of the heat pipes and to identify technical problems. Ano
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Microbubble-mediated transfection of Peptide Nucleic Acid conjugates targeting mRNA quadruplexes to modulate gene expression in vivo' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The regulatory functions of RNAs rely on their propensity to adopt defined secondary structures. G-rich nucleic acid sequences have a propensity to form highly stable four-stranded structures (termed quadruplexes) in the presence of physiological monovalent cations. Using an approach that consists in targeting simultaneously the quadruplex structure itself but also the two single-stranded RNA flanking regions in a sequence-specific manner, we demonstrate that RNA quadruplexes represent a valid therapeutic target for chemical intervention to modulate the translation of specific genes (notably N-Ras, Aurora kinases A and C) both in vitro and in vivo. Peptide nucleic acids (PNAs) are used as antisense oligonucleotide analogues to direct a quadruplex-stabilising platform to the only gene of interest, thus making this class of compounds capable of discriminating between an RNA quadruplex and other nucleic acid secondary structures, including other RNA quadruplexes. This novel approach for specifically silencing genes is likely to have great therapeutic potential. Once validated in vitro, this strategy will be applied in vivo, using for the first time microbubbles to facilitate the delivery of neutral oligonucleotide analogues (i.e. PNAs) in cellulo. Co-injection of microbubbles and antisense oligonucleotides, combined with localised ultrasound treatment has been successfully applied for gene delivery to specific organs. Herein, transfection of the PNA-based RNA quadruplex ligands will be carried out using microbubbles with variable shell compositions and different transfection methods (co-injection, encapsidation, covalent attachment) will also be considered. Transfection efficiency will be quantitatively evaluated by fluorescence confocal microscopy and correlated with the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Assessment of the occupational relevance of allergens based on their molecular structure, metabolism and cross reactivity to related chemical compounds' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Objectives:In this proposal, four groups with longstanding interest in immune responses to haptens will combine their efforts to better understand the development of occupational allergies to understand crossreactivities on a molecular level and to generate rules to avoid sensitizations against these compounds.The goal of this study is to define criteria responsible for the development of occupational allergies and to provide concepts to prevent these allergies.Brief descriptions:Allergies to low molecular weight compounds are of major public and occupational importance in certain professions like i.e. pharmaceutical industries (drug production), construction workers (chromium), or hair dressers (p-phenylendiamine). These studies include the characterisation of cytochrome P450 isoenzymes in antigen presenting cells.Since several occupational allergens exhibit a widespread distribution extending far above the occupational environment and since crossreactive compounds may also trigger the disease, sensitizations against these allergens may have an impact on the extraoccupational life of the sensitized individuals. This may result in the perpetuation of a particular allergy even after discontinuation of the occupation. A better understanding of crossreactivities to other compounds may thus be essential for the avoidance of these allergenic compounds. Keywords:Occupational allergy, reactive haptens, cytochrome P450, T cell responses, crossreactivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Paving the way toward HIV eradication/control' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Human Immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, infects primarily cells of the immune system. The outcome of HIV-1 infection results from complex interactions between viral proteins and host cell factors (ref). In most cases, HIV-1 successfully hijacks cellular pathways and bypasses cellular restriction factors for optimal replication leading to continuous rounds of infection, replication and cell death (ref). Continuous viral replication causes the loss of CD4+T cells and progression to immunodeficiency in infected individuals. However, in certain situations virus replication can be successfully controlled. First, HAART (Highly Active AntiRetroviral Therapy) treatment revealed the existence of a pool of resting memory CD4+ T cells harbouring integrated but silent HIV-1 provirus. Although this situation occurs in a small number of cells, it suggests that intracellular defence mechanisms can be effective against HIV. This long lived viral reservoir is believed to be the major obstacle against HIV-1 eradication by HAART. Second, HIV-infected individuals who are able to control their virus to undetectable levels for many years in absence of any treatment have been identified and referred to as Elite HIV controllers EC . Again, this is a rare situation observed in 0.5% of infected patients. Still, it demonstrates that it is possible to naturally and effectively control HIV replication and disease progression. A common feature of these two situations is that virus replication is controlled at the gene expression level. A major challenge in the HIV field is to understand how these naturally occurring situations where intracellular defence and/or immune response win the battle against HIV. Our project aim at identifying the host factors and define the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An Exercise to Assess Research Needs and Policy Choices in Areas of Drought', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In recent years large parts of Europe suffered from extreme drought, a phenomenon that likely will become more frequent and more severe, as predicted by the climate models. This will lead to significant socio-economic and environmental impacts and associated damages. There is therefore an urgent need to develop a roadmap toward a European Drought Policy, in accordance with the EU-Water Framework Directive (WFD) and related EU Legislation and Actions. The aim is to mitigate and to adapt to droughts, and hence reduce the risks they pose in Europe. XEROCHORE SA compiles a roadmap that comprises of: 1) a state-of-the-art review and identification of the research gaps in the natural system, in impact assessment, in policy-making and in integrated water resources management, and 2) an assessment of the possible impacts of droughts and guidance on appropriate responses for stakeholders. An extended network of experts will gather inputs for the roadmap through focussed workshops, round table discussions, which integrate the various aspects, and a concluding conference. A Core Group will guide and facilitate the discussion and synthesis process, and eventually write the integrated roadmap. The project network consists of over 80 organizations including research institutes, universities, ministries, water management organizations, stakeholders, consultants, international organizations and programmes. It includes key members of the European Drought Centre and the WFD-CIS Working Group on Water Scarcity and Drought and representatives from overseas and neighbourhood countries, in particular around the Mediterranean Basin. The large number of organizations covering different aspects and geographic regions guarantee that all drought aspects will be covered. The drought network will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Inference for Semi-Nonparametric Econometric Models'.

assistant: **Objectives**

This research project aims to contribute to advances in the research on semiparametric and nonparametric econometric methods by developing novel estimation and inference approaches in a variety of contexts and applying them to important empirical problems in economics.The project is divided into four parts. The first part develops a Bayes procedure for the moment condition model. A likelihood function is constructed by employing an information theoretic projection from space of nonparametric prior distributions on data to space of distributions satisfying the moment conditions. Posterior sampling methods and asymptotic theory for the posterior are developed.The second part focuses on the moment condition model but from a different perspective, robustness of decision methods. By focusing on local perturbations within shrinking topological neighborhoods, this part develops a framework to evaluate robustness of inference methods for the moment condition model. It is found that there is a computationally convenient method that achieves optimal minimax robust properties under local perturbations without losing asymptotic equivalence to GMM under correct specification.The third part develops nonparametric regression techniques for extremal or tail behaviors. This part develops asymptotic theory for nonparametric quantile regression when the quantile drifts to 0 or 1 as the sample size increases. Based on the theory, a new inference method for extremal behaviors is developed.The fourth part extends the empirical likelihood approach to a variety of empirical problems in economics. This part develops empirical likelihood inference methods for regression discontinuity designs, continuity or discontinuity of probability density functions, volatility measurement in high frequency f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification of the mode of action of plant defensins during root development and plant defense responses.' under Horizon 2020.

assistant: **Concept**

Plant defensins are small highly stable peptides and were originally isolated based on their antifungal activity. They are regarded as being an important part in plant innate immunity responses directed against fungal pathogens. Recent data suggests however that their role is not restricted to antimicrobial peptides in the defense response, but also includes important biological functions, such as root development and reproduction. Surprisingly, despite the broad international interest in plant defensins, their mode of action in plant defense responses is still unclear as well as their possible involvement in (other) biological functions. The project aims to unravel in depth the biological function and mode of action of the plant defensin AtPDF2.3 and its closest homologue AtPDF2.2. Our complementary approach will focus on alternative modes of action of these plant defensins relevant for plant defense and root development, allowing to find clear answers about their biological functions, being: (1) their role during root development, (2) their role during plant defense (3) their mode of action in plants and (4) their antifungal mode of action. The envisioned long term goal of this project is to identify novel strategies to cope with biotic stress and regulation of root architecture to be applied on important agricultural crops. The project has a strong multidisciplinary nature, combining bioinformatics, genetics, microbiology and molecular biology approaches. The project bridges the knowledge and expertise of the applicant in root development and confocal microscopy with the that of the host in plant-fungi interactions. With the implementation of the project the applicant will be trained in a new field, being plant-fungi interactions, able to learn new scientific skills
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Enhancing the innovativeness of food SME’s through the management of strategic network behaviour and network learning performance'.

assistant: **Innovation**

Strategic network learning is of crucial importance for innovation as it enables the food company to expand its resource base and to absorb new trends and technologies. It is observed that food SMEs often fail in establishing a strategic and efficient network. This project sheds new light on this issue by combining research actions at two levels: the focal company level, investigating how attitudes and preferences determine the food SME’s individual network behaviour in order to achieve business objectives. The network level, investigating the functioning of the network as a whole and how this results in innovation and economic growth and how network stakeholders can make the network better performing. The project combines scientific research with developing network learning tools of practical use to food SMEs, network organisations and policy makers. A broad definition of networks is applied, including networking with competitors, suppliers, knowledge centres and a variety of other actors through formal and informal linkages. Research activities take three steps: (1) profound analysis of success factors and barriers for network learning. Particular focus is on the relationship between informal and formal networking and global networks. (2) Network behaviour is analysed at the focal company level, providing insight in network characteristics affecting innovation and SMEs’ preferences for different network designs. (3) a prototype tool is developed and tested to assess performance of the network at network level. In the development stage of the project, the network learning toolbox will be developed, market-tested and launched. It consists of a set of instruments to enhance the capacity of SME’s, network organizations and policy makers to improve network learning based o