RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Stratification of Rheumatoid Arthritis: CompuTational models to personalise mAnagement strategies for difFIcult-to-Treat disease' (STRATA-FIT), addressing dissemination and exploitation.

assistant: **Impact**

Difficult-to-treat rheumatoid arthritis (D2T RA) is an area of huge unmet medical need with major socio-economic consequences for patients and society. Contributing factors have been identified including co-morbidities, drug-related, biological and behavioral factors. However, identifying these patients with specific underlying and overlapping problems, or patients at risk, is a big challenge in practice.Currently, treatment decisions are random and not sufficiently patient tailored nor data-driven. Therefore, the STRATA-FIT consortium sets out to develop and validate computational models to identify and stratify D2T RA patients into clinically relevant phenotypes using real world clinical data. We will also measure biomarkers of inflammation to further characterise these phenotypes.Subsequently, we will execute a pilot study with a clinical decision aid based on our models to assess the effectiveness of personalised treatment strategies. In parallel we will develop a computational model to identify early RA patients at risk of developing D2T RA. By doing so, not only will we provide better treatment for patients with D2T RA, but also work towards its prevention in early RA patients. STRATA-FIT will establish a unique European Learning Healthcare System, using a privacy-proof, state-of-the-art federated learning infrastructure in which patients with, or at risk of D2T RA are identified, stratified and treated in a personalised manner.STRATA-FIT builds on previous work by consortium partners, who initiated and lead the European Task Force on developing points to consider for managing D2T RA. It brings together clinical experts, patient research partners and clinical-, biological-, data- and computer-scientists to tackle this major clinical challenge. When successful, STR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'All-optical sub-THz signal filtering with multi-COLOR lasers' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

MicroWave Photonics (MWP) has been delivering on-chip devices with outstanding performances to answer the demand of Information and Communication Technologies for always faster, more efficient and more compact systems. Yet, some stringent limitations form a roadblock for disruptive specifications: for instance, on-chip MWP frequency filters hardly perform beyond 60 GHz, whereas the technology and applications require frequencies in the sub-THz range from 100 GHz to several THz. This frequency band will directly support future ultra-fast telecom systems, but also sensing techniques such as THz spectroscopy e.g. for food contaminant detection or mm-precision RADARs for robotic systems.With COLOR'UP, my goal is to remove this frequency roadblock by exploring and implementing on-chip a radically new concept exploiting the nonlinear dynamics of multi-colour lasers. These lasers naturally generate a set of sharp beat-notes in the sub-THz range corresponding to the frequency separation between the different wavelengths. Injecting an optical beam in a multi-colour laser with a modulation at well-chosen frequencies can lead to injection-locking of all wavelengths simultaneously. Spectral components that are not matching the beat-notes will however not be picked up and will be filtered out in the laser output.In this project, I will demonstrate that this effect can be exploited to create all-optical on-chip MWP bandpass filters with the capability to cover the entire sub-THz range from tens of GHz, up to a few THz. My goals are four-fold: (1) design and realize multi-colour lasers with tailored spectra to achieve filtering at precise frequencies (2) study the underlying filtering mechanism to optimize the filter performances (3) develop on-chip control techniques based on optical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'First Targeted  Therapy to FIGHT Hemophagocytic Lymphohistiocytosis (HLH): A novel  approach to HLH' in the context of a Seventh Framework call.

assistant: **Objectives**

Hemophagocytic lymphohistiocytosis (HLH) is a rare, devastating disease characterized by uncontrolled immune response that primarily affects young infants and children. HLH is usually fatal if untreated. Even when treated, the overall survival rate is still as low as 60-70%. No drug has been formally developed for the treatment of this disease and current treatment methods require the use of drugs which have not formally been developed for this indication which have an unfavourable safety profile. The cytokine interferon-gamma (IFNγ) was shown to play a key pathological role in the disease. It has been demonstrated that neutralization of IFNγ with a monoclonal antibody (mAb) reverts the disease and rescues animals from death in murine models of primary HLH. In patients, evidence points towards a correlation between levels of IFNγ and disease activity. In order to target IFNγ in patients with HLH, NovImmune generated and characterized a fully human mAb, NI-0501, that neutralizes the biological activity of human IFNγ. This consortium proposes an adaptive clinical trial with a pilot and a pivotal phase to provide the necessary data for Market Access Authorization for NI-0501 in HLH. The pilot phase will enroll only patients well-known to have a primary form of HLH and who relapsed after having responded to an initial treatment while the pivotal phase will open the recruitment to newly diagnosed HLH patients. The transition between the pilot and the pivotal phase will be governed by strict pre-defined transition rules and will only occur if a favorable benefit-risk profile has been demonstrated. During the course of the pilot phase the consortium will attempt to generate the necessary information to justify the inclusion in the pivotal phase of a broad range of HLH patient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular Storage System (MoSS): Intelligent DNA Data Storage' (MoSS).

assistant: **Innovation**

Molecular Storage System (MoSS): Intelligent DNA Data StorageSeveral groups, including Helixworks, have demonstrated DNA storage systems over the last few years. The information stored has steadily increased from a few kilobytes to several hundred megabytes. However, current DNA synthesis techniques based on phosphonamidite chemistry are designed for manufacturing error-free DNA for biological applications. Today, synthetic DNA costs $0.001 per nucleotide, making DNA storage seven orders of magnitude more expensive than tape.Based on results generated from the FET Open project ?OligoArchive? (grant agreement 863320), three of the participants (Helixworks Technologies Limited, Imperial College of Science Technology and Medicine, and EURECOM)  are seeking to take the OligoArchive results further, through the development of MoSS ? a new DNA storage system based on a novel enzymatic technique for writing DNA at scale (this innovation was assessed by the JRC?s Market Creation Potential indicator framework as having a ?High? level of market creation potential).In MoSS, we will investigate novel enzymatic synthesis techniques that can dramatically reduce cost of DNA synthesis by exploiting that using DNA as a data storage medium does not require precise, error-free synthesis. Our consortium members are at the forefront in both academic research (Imperial, Eurecom) in structural biology (especially DNA-binding proteins), synthetic biology, and automation (including cell-free protein synthesis), and industrial research (Helixworks) in pursuing novel, scalable, enzymatic synthesis techniques that can offer low-cost, high-throughput write path to DNA storage.


**Keywords:** DNA, storage, databases, sequencing, synthesis, archival data, automation, structured data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative materials and techniques for the conservation of 20th century concrete-based cultural heritage' (InnovaConcrete).

assistant: **Concept**

InnovaConcrete is an innovative and ambitious proposal that aims at preserving concrete-based monuments, the most significant tangible Cultural Heritage (CH) in the 20th Century. To achieve this goal, we have recruited an interdisciplinary team presenting a strong scientific background in simulation techniques and nanomaterials synthesis, combined with a wide knowledge of CH conservation from Humanities disciplines and, a sound industrial perspective. Specifically, a completely innovative approach based on producing C-S-H gel, responsible for the engineering properties of cement paste in cracks of decayed concrete monument, in situ, will be developed. Complementary, other innovative solutions giving rise to superhydrophobicity and corrosion inhibition will be also investigated. In addition, InnovaConcrete will explore an approach based on biotechnology: enzyme-assisted self-healing of damaged surfaces. The optimization of the solutions proposed will be carried out by the use of theoretical tools (multi-scale modelling approaches) together with experimental tools (laboratory and in situ validation). Significant 20th century monuments, such as the spectacular building, Centennial Hall, the open-air sculptures of Eduardo Chillida, War Memorial Towers and concrete shell structures, typical construction in communist period will be used as case studies to validate the performance of the solutions proposed. These monuments, a clear representation of European CH, will be employed to study economic and other societal effects of the proposal and to promote citizens' awareness of 20th century European heritage. Finally, the activities required for the future commercialization of the InnovaConcrete products, including standardization, certification, life cycle assessment, scaling u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EpiShuttle: Isolation and Transportation of Infectious Disease Patients' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The Problem: An increasing number of outbreaks with infectious diseases are seen globally. Ebola has claimed at least 77 lives in DRC (Congo) so far this year and over 11 thousand people West Africa in 2014. Other recent outbreaks are the SARS-epidemic, the MERS-cases in Asia, multi-resistant tuberculosis and the pulmonary Plague epidemic in Madagascar, Zika virus in Brazil, etc. Each of these events demonstrated the large health, economic and security risks associated with infectious disease outbreaks. The travelling patterns of our modern society increases the risk of a global “catastrophe”. To handle outbreaks, the CDC highly recommends the use of specialized isolation units (SIU) to isolate and transport the infected patients. The Solution: EpiGuard was founded in 2015 by a group of medical doctors that faced the challenge of managing Ebola patients on the field. After 3 years and ~5 million EUR of capital and labour investment, the company has recently launched into EU market the EpiShuttle solution – the world-first hard-top (polycarbonate), reusable SIU, representing a leap forward against the state of the art. The EpiShuttle is a one-person SIU, providing complete protection from contagious diseases, without compromising advanced treatment and care to the patient. The Opportunity: Partnering with a world-class design and engineering team, EpiGuard wants to position EpiShuttle as the gold standard for SIUs in the emergency workflow. EpiShuttle targets a 12 Bill. EUR market opportunity worldwide. Although the response from medical professionals has been positive, to fully exploit the market potential, there is a need for combining modern gas disinfection technology with EpiShuttle to allow re-use in a cost effective manner.  Further, to expand the market outside E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Linear ubiquitin chains - novel cellular signals involved in inflammation and cancer' (LINEUB).

assistant: **Innovation**

Ubiquitin (Ub) is a small modifier that labels proteins in a highly specific manner. Like phosphorylation, modification of proteins by Ub is prevalent in the majority of cellular processes. An increasing number of distinct functions have been assigned to different types of ubiquitin modifications (monoUb and different Lys-linked chains). Moreover, aberrations in the ubiquitin system underlie many disease states, including cancer, inflammatory, immune and metabolic disorders as well as neurodegeneration. The most recently described physiological ubiquitin modification is the linear ubiquitin chain, in which ubiquitin monomers are conjugated via Met-Gly linkages. We have found that linear ubiquitin chains bind specifically to the NEMO adaptor molecule, an event critical for the proper regulation of NF-ºB signaling (Rahighi, 2009). Here we propose to use a multidisciplinary strategy to study the role of linear ubiquitination in the NF-ºB pathway, autophagy, apoptosis and DNA repair and how these changes can impact on disease states such as inflammation and cancer development. Scientific objectives are:  Characterize the components of linear ubiquitination: E3 ligases, specific substrates and domains recognizing linear ubiquitin chains " Elucidate the in vivo role of linear ubiquitination in the regulation of the NF-ºB pathway, apoptosis and DNA repair. " Reveal the molecular basis for the connections between linear ubiquitination and selective autophagy " Identify elements in the linear ubiquitin network as potential drug targets " Generate transgenic mouse models of inflammatory diseases and cancer " Develop system and computational biology approaches to assess the global role of linear ubiquitination in cellular proteome"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Research, development and technological testing of a high energy flywheel of 20 kWh energy storage and 10 kW power' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives To define the energy storage capacity and power as required by the market for residential peak shaving and load management. To design, develop and test a laboratory prototype High Energy Density Flywheel system having energy storage capacity and power as defined by the market analysis. As maximum target values 20 kWh and 10 kW are put forward. To define the techno-economical parameters to make the High Energy Density Flywheel system an efficient load matching factor for renewable energy sources. To define the necessary safety requirements. Technical Approach A detailed analysis of a large number of load diagrams will be made by the Belgian utility Electrabel. From this analysis the best set of performance parameters - energy storage and power - and maximum allowable investment cost will be determined. These parameters will be the starting point for the design of a first laboratory prototype. This prototype will be used to test the concept with regard to its performance, safety, dynamic behaviour etc. It will also serve to validate the models used in the preliminary market analysis, i.e. to compare the real peak shaving efficiency to the presumed one. From this experience a second prototype will be developed and tested in a 'real world' situation. Expected Achievements and Exploitation This project aims to understand the peak shaving capacity and in general the capacity to perform load management in a residential environment with systems based upon High Energy Density Flywheels. It should also clarify the techno-economical feasibility of such systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Product Data technology Europe 2002'.

assistant: **Concept**

The conference 'PDT Europe 2002', will take place on 7-9 May 2002 in Turin, Italy. The Globalisation of business, the shift toward an economy of fast changing opportunities, the evolution of enterprises toward networked or virtual organisation, and the faster pace of ICT evolution and obsolescence, has put pressure on manufacturing industries to search for effective software interoperability solutions. The importance of quick, reliable information exchange between partners in the current Information Society is increasing and Product Data Technology provides the only practical solution to this demand. PDT Europe will bring together and encourage the interchange of PD Technology and PD Management implementation (in EU, Associated States and Third Countries) and provide EU project awareness to a global market. The operation will include support tools such as event website, newsletters, mini-exhibition, and a work package to analyse and publish results. The main conference will be enhanced by focused technical workshops or sessions addressing specific technical issues and the challenges of a service-based and dematerialised intangible economy, in line with the policies of DG INFSO. Presenters will be drawn from industry and academia, EU project leaders, scientific officers, and other leading experts. An international audience exceeding 150 delegates will be drawn from managers, decision makers, implementers, and project engineers from the global business sectors, academia and standard authorities. The event will include innovative focused workshops addressing topical issues (with subjects identified by leading industry experts), under the chairmanship of respected industry experts, and encouraging interactive delegate participation. A report on the workshops will be publish
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ferrites-by-design for Millimeter-wave and Terahertz Technologies' (FeMiT) targeting Horizon 2020.

assistant: **Abstract**

Robust disruptive materials will be essential for the “wireless everywhere” to become a reality.  This is because we need a paradigm shift in mobile communications to meet the challenges of such an ambitious evolution. In particular, some of these emerging technologies will trigger the replacement of the magnetic microwave ferrites in use today. This will namely occur with the forecasted shift to high frequency mm-wave and THz bands and in novel antennas that can simultaneously transmit and receive data on the same frequency. In both cases, operating with state-of-the-art ferrites would require large external magnetic fields incompatible with future needs of smaller, power-efficient devices. To overcome these issues, we target ferrites featuring the so far unmet combinations of low magnetic loss and large values of magnetocrystalline anisotropy, magnetostriction or magnetoelectric coupling.  The objective of FeMiT is developing a novel family of orthorhombic ferrites based on ε-Fe2O3, a room-temperature multiferroic with large magnetocrystalline anisotropy. Those properties and unique structural features make it an excellent platform to develop the sought-after functional materials for future compact and energy-efficient wireless devices. In the first part of FeMiT we will explore the limits and diversity of this new family by exploiting rational chemical substitutions, high pressures and strain engineering. Soft chemistry and physical deposition methods will be both considered at this stage.The second part of FeMiT entails a characterization of functional properties and selection of the best candidates to be integrated in composite and epitaxial films suitable for application. The expected outcomes will provide proof-of-concept self-biased or voltage-controlled signal-