RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enigma – Histone Deacetylase protein complex controls cardiac hypertrophy' (ENIGMA) targeting Seventh Framework.

assistant: **Abstract**

A variety of cardiovascular disorders provoke the heart to enlarge through hypertrophic growth of cardiomyocytes, resulting in heart failure and sudden death. Based on in vivo and in vitro models of cardiac hypertrophy, it is apparent that histone-modifying enzymes act as key regulators of cardiac growth. Although their upstream regulation has been studied, the mechanism whereby class IIa Histone deacetylases (HDACs) repress transcription has not been elucidated.In preliminary studies, we performed an association screen with the Class IIa HDAC4 and a heart cDNA library, and identified the protein ENIGMA as an HDAC4 binding partner. Further studies showed that other PDZ and LIM proteins do not bind class IIa HDACs, and that ENIGMA can bind class I HDACs with its PDZ domain and class IIa HDACs with its 3LIM domain. These novel preliminary results give rise to our main hypothesis that Enigma is a protein scaffold anchoring class I HDACs to class IIa HDACs to create a complex with high deacetylase activity that represses cardiac hypertrophy.A combination of detailed studies will be conducted to gain an understanding of the composition of this protein complex and its biological role. Specifically, I propose to (1) map the interactions between class IIa HDACs and ENIGMA in detail; (2) determine the endogenous class I HDACs-ENIGMA-Class IIa HDACs' ternary complex; and (3) determine the role of the ENIGMA complex in suppressing hypertrophy in vivo.Multidisciplinary approaches will be used to examine this hypothesis. Biochemical and molecular biology methods, as well as yeast assays, will be used to assess the interaction between ENIGMA and the HDACs. Further cell biology studies will examine the biological role of the ENIGMA ternary complex in cardiomyocytes in primary cultures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Biosensors for in situ evaluation of bioavailability of pollutants based on transcriptional regulators a la carte.'.

assistant: **Concept**

This Project exploits the properties of prokaryotic transcriptional regulators of the XylR/HbpR family to design a la carte regulators that will be employed to determine the bioavailability of nitro-, broom- and chloroaromatic chemicals and biphenyl ethers. The core of this proposal is the application of high-throughput combinatory genetic technologies to the protein module that sets the specificity of the response to distinct aromatics. This will allow the generation and selection of regulator variants able to recognize and to trigger responses to a large variety of chemical species. The selected proteins will be employed in various biosensor schemes through the coupling of the cognate promoters to genetically formatted lox and gap reporters. This genetic standardisation will going parallel with matching instrumentation, hardware and software suited for measuring the optical output of the system and its utilisation in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Connecting LOng and Short-distance networks for Efficient tRansport'.

assistant: **Innovation**

The European Transport Policy (ETP) proposes the concept of co-modality as an essential instrument to achieve, at the same time, a high level of mobility and of environmental protection. But the existing transport system still remains far away from that concept. The interface between long and short-distance transport networks remains as the weak link in the transport chain for both, passengers and freight. This situation favours the choice of uni-modal solutions, and jeopardizes the development of more competitive and sustainable transport chains. The improvement of long/short distance interfaces is a key element to achieve the objectives of the ETP. Approaches to this issue have typically been developed at the project level, on a case-by-case basis. At best, decision-makers benefit from experiences in other regions, but conflicts are rarely considered and solved in advanced, and they are rather addressed as they emerge, so that optimal solutions are rarely adopted.  The purpose is to develop innovative tools for the analysis of interfaces, check these tools in a number of case studies, and make recommendations to stakeholders in order to get: -A more systematic approach to the whole project cycle of interfaces.  -Concrete guidelines for decision makers in order to cope with the challenges of a particular project, and to get the most from the opportunities that each project offer.  -A friendlier regulatory environment; fostering cooperation and supporting better integrated interfaces.  -Improved mechanisms for financing those concepts with a higher degree of integration (including EU’s funding schemes).  -In-depth involvement of stakeholders, and particularly of transport operators.  Research has focused thus far on quite specific aspects of the interface problem. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'CONTROL OF CLASSICAL SWINE FEVER BY MOLECULAR DIAGNOSIS AND EPIDEMIOLOGY'.

assistant: **Objectives**

Background :Despite intensive efforts, it has not proved possible to eradicate classical swine fever(CSF) in Europe and new outbreaks of the disease continue to occur within EU member states and Eastern Europe. Not only the direct costs but also the indirect costs, relating to international trade of both live pigs and pig products, of these outbreaks are enormous. In order to deal with outbreaks, there is a short term need for improved diagnosis and a longer term need for a better understanding of why the disease is reappearing. The objective is :This research proposal seeks to address both the need for improved CSF diagnosis and the need for identifying the routes of continuing disease spread. The former will be dealt with through the development, optimisation and harmonised validation of new diagnostic methods based on detection of CSF virus antigens and RNA; the latter through the development of molecular epizootiological methods to permit the origin and spread of outbreaks to be more precisely determined. Short description of the project :As regards diagnostic tests, particular emphasis will be placed on establishing tests based on reverse transcription - polymerase chain reaction (RT-PCR) for screening blood samples of live pigs and tissue from abattoir carcasses. Molecular epidemiology will be based on the establishment of a specific fingerprint for each outbreak that will be compared to others in order to determine the likely patterns of the spread.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unravelling the effect of divergent concentrations of progesterone in early pregnancy on foetal development in the cow' under Horizon 2020.

assistant: **Concept**

Uterine receptivity and the dialogue between the embryo and the mother in early pregnancy is mainly driven by the concentrations of the steroid hormone progesterone (P4). Work from the host laboratory has shown that divergent P4 concentrations early in pregnancy strongly influence embryo growth and survival in cattle but are not always associated with improved pregnancy rates. Importantly, the consequences of suboptimal P4 for later foetal development are largely unknown. This project proposes four Research work packages (WP) to interrogate the effect of P4 concentration early in pregnancy on the development of the maternal-placental-foetal unit in the cow. The first three WP are built around two groups of cows, manipulated to have high or low P4 during the first days of pregnancy, and a third untreated group, as control. In WP1, foetal growth will be followed through ultrasound scanning until four months of pregnancy (~40% of gestation), when the foetus and associated membranes will be recovered for WP2 and 3. Development of the placenta and amniotic fluid composition will be assessed through transcriptomics and metabolomics, respectively, in WP2. Foetal maturity will be determined in WP3, through organ measurements and histology, and transcriptomic analysis of the hypothalamus (a pivotal organ for development). In WP4, endogenous P4 in dairy cattle across pregnancy will be correlated with calf birth weight. In addition, WP5, 6 and 7 will deal with Management, Training, and Dissemination, respectively. Modelling of metabolomic and transcriptomic data will increase knowledge of the functional and molecular regulation of bovine pregnancy and foetal physiology. Furthermore, this novel information could lead to new therapeutics to optimise the development of a healthy offs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Speeding up intra-system data transfer through optical data links and minimizing energy demand by a new generation of integrated circuits' under Horizon 2020.

assistant: **Concept**

The application of cutting-edge technologies like AR/VR or artificial intelligence in consumer products and industry demand for high-performance data transfer between processors, memory and peripherals. This is valid for e.g. self-driving cars but also for industrial data centres. However, the limiting factor nowadays (and for future scaling) is the data transfer within the system, specifically, by the factors: bandwidth, power, and space. In fact, so-called interconnects cause 30% of power consumption in data centres today (and data centres account for currently 2%, in the future estimated 8%, of electricity worldwide). At higher speeds, the electricity cost of currently used copper links already dominates over the hardware cost. Due to this and their unsustainable signal loss, copper links are increasingly replaced by optical solutions, e.g. vertical-cavity surface-emitting laser (VCSEL), which provide negligible frequency dependent loss, a high bandwidth and 10-times lower power consumption. The VIS team has repeatedly reached performance world records for their VCSEL products based on proprietary transmitter and receiver assemblies and own integrated circuits (ICs). Facing the challenge of continued scaling and data transmission capacity needs >200Gb/s, the industry needs a new generation of VCSEL chips. To develop those, some further optimized ICs are most important. Currently, IC development is outsourced by VIS with a significant supervising effort. Main objective of this proposal is to hire and integrate an IC design expert to finally extend IC performance in VIS VCSELs to enable 224Gb/s PAM4 single channel transmission at energy consumption of 1mW/Gbps (triple speed performance and -50% energy demand). The VIS business opportunity is to provide complete proprie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Union AI Uncertainty Reduction and Alignment' (EU-AURA) targeting Horizon Europe.

assistant: **Abstract**

91% of AI fails post-deployment, according to a recent publication in Nature by Harvard and MIT. This corresponds to over €10 billion in estimated losses in the EU alone, mainly because real-world AI model performance cannot be monitored or aligned. We've developed five novel generically applicable algorithms to estimate AI performance with groundbreaking accuracy. NannyML empowers data scientists to assess AI post-deployment, ensuring large-scale efficacy reducing risk, costs, and biases. Data scientists, increasingly at the helm of European projects, select products anchored in innovative research. Our strategy is based on transparent, product-led promotion, with distribution on cloud marketplaces driven via blogs, papers, and professional communities. NannyML’s open-source solution is one of the most widely adopted AI monitoring solutions in the world, with over 2,000 known monthly active instances, 20,000 monthly downloads, and a community of 50,000 data scientists. NannyML has been implemented at Europe's leading corporations like Essilor Luxottica, Ahold Delhaize and TUI. Our next major milestone is commercializing NannyML’s technology. Europe is at a pivotal moment in history, and the world needs European AI that is properly Aligned. With the support of the European Innovation Council NannyML will ensure Europe leads the world in delivering Aligned AI.


**Keywords:** Machine Learning Monitoring, Artificial Intelligence, Post-Deployment Data Science, Detecting Model Failure, Root Cause Analysis, Increasing AI Safety, Reducing AI Uncertainty, AI Enablement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Foundations in medieval societies: Cross-cultural comparisons' (FOUNDMED), addressing dissemination and exploitation.

assistant: **Impact**

In the present foundations are ascribed a central role in overcoming social and political problems, be it in the field of social welfare or the sponsorship of science and the arts. But they were also in the past always an indicator of the condition of a society and lend themselves to deducing its overall structure. In a historical perspective they permit an intercultural comparison because there is evidence of the phenomenon of the foundation, while not on a continual basis, in all advanced civilizations. The project intends to carry out a comparative investigation of foundations of the medieval millenium (from approximately 500 to 1500 CE) in European Latin and Greek Orthodox Christianity, in Judaism, Islam and in pluri-religious India and of their mutual relations while making use of the ideas of modern global history. It will therefore also involve questions of cultural transfer or cross-cultural interaction. Under the leadership of the submitter five experts from the fields of Medieval, Byzantine, Jewish, Islamic or Ottoman and Indian studies will compile an ""Encyclopedia of Foundations in the Medieval Millenium"", in which articles written collaboratively will depict the forms, objectives, legal structures, endowments of the foundations and historical changes taking place within them, taking into consideration their religio-historical background (esp. end time concepts) and their respective historical context. The planned project is built upon pilot projects working on this issue, while a publishing company has already secured the rights for the publication of such an encyclopedia (also online). On completion of the project the submitter will also present a monograph on foundations in the Middle Ages as ""total social phenomenon"" (M. Mauss) in an universal histor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A long-acting, constant release ocular implant for the sustained delivery of biologics and small molecules for the treatment of retinal diseases.' (BlueDot), addressing dissemination and exploitation.

assistant: **Impact**

Seventy-six million people will suffer from blindness by 2020. Age-related retinal disorders - macular degeneration (AMD) and diabetic macular edema (DME) are two of the leading causes of blindness in the world. About 200,000 new cases of advanced, age-related AMD identified each year in the United States and between 14.9 and 21.5 million cases of early AMD, and between 3.9 and 4.8 million cases of late AMD is expected in Europe by 2040. The complexity of eye anatomy presents challenges for treatment. Current treatment, intravitreal injections (IVI) are the highest growth medical procedure in the globe, with an estimated 20 million intravitreal injections globally in 2016. Ranibizumab, treatment blocking vascular endothelial growth factor (VEGF), which promotes blood vessel growth, costs approximately $2,000 in USA and €1000 per injection. Patients may need up to 12 injection per year. Additionally, this treatment significantly affects patient comfort.MicroSert has developed BlueDot – a novel, long-acting release (LAR) ocular implant for the sustained delivery of biologics and small molecules for the treatment of retinal diseases. BlueDot is implantable to the tear duct and releases therapeutic inside the eye. Implantation requires one-step office-based procedure using proprietary implantation device with safety monitoring system and with no incision needed. BlueDot is refillable and lasts up to two years.The SME-I Phase 1 project perfectly suits the innovation’s current stage of development and overall business strategy allowing MicroSert to check final specifications of BlueDot, establish a sound business development and gain partners necessary for the Phase II study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A New Strategy for Gravity and Black Holes' (GravBHs), addressing dissemination and exploitation.

assistant: **Impact**

General Relativity (GR) encompasses a huge variety of physical phenomena, from the collision of astrophysical black holes, to the dynamics (via holography) of strongly-coupled plasmas and the spontaneous symmetry-breaking in superconductors. Black holes play a central role in all this. However, their equations are exceedingly hard to solve. The apparent lack of a generic tunable parameter that allows to solve the theory perturbatively (like the electric coupling constant in electrodynamics, or the rank of the gauge group in large-N Yang-Mills theory) is arguably the single most important obstacle for generic efficient approaches to the physics of strong gravity and black holes. I argue that one natural parameter suggests itself: GR can be defined in an arbitrary number of dimensions D. Recently I have demonstrated that the limit of large D is optimally tailored for the investigation of black holes, classical and potentially also quantum. Explicit preliminary studies have proved that the concept is sound, powerful, and applicable even in four dimensions.This encourages the pursuit of a full-scale program with two major goals:(A) Reformulating GR and Black Hole physics around the large-D limit in terms of an effective membrane theory of black holes, coupled (non-perturbatively in 1/D) to an effective theory for gravitational radiation.(B) Resolution of outstanding problems in gravitational physics, in particular of problems of direct relevance to cosmic censorship (critical collapse, endpoint of black brane instabilities), and of the quantum theory of black holes.With the new tools of (A), a large number of additional problems in black hole physics and in holographic duality can be solved, which guarantee very substantial fallback objectives. These include black hole coll
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'GENETIC AND GENOMIC STUDY OF CELL COMPETITION IN DROSOPHILA' (SUPERCOMPETITORS) targeting Seventh Framework.

assistant: **Abstract**

During initial stages a cell accumulating tumor-promoting mutations is usually surrounded by normal cells. Current cancer models do not incorporate this transition from a single cell to a field of cells, although it is probably critical, since the behavior of an individual tumor cell within the cell community has to be dictated by the hard-wired genetic program that controls its aberrant cell biology and modulated by the plastic interactions with neighboring normal cells. Study of model organisms, such as yeast, C. elegans, or Drosophila, has historically pioneered crucial contributions to processes with important implications in neoplasia. Recent work in Drosophila has proposed a role for cell-competition and super-competition in early stages of cancer formation. Cell competition is a type of cell-cell interaction in which more competitive cells replace less competitive cells (Morata and Ripoll, 1975; Moreno et al. 2002). During the last year, my laboratory has performed the first microarrays to find genes involved in cell competition, as well as developed an in vitro system for cell competition. The genes identified in the microarrays are not downstream dMyc but are rather induced at the boundaries where cell competition takes place and seem to be upstream apoptosis induction. The new genes will be studied in vivo in Drosophila and in vitro with RNAi. We will also perform other microarray settings to subdivide the genes in different categories. Thanks to the complete genome sequences of both Drosophila and humans, those genes could be used to find human homologues that could serve as novel markers and targets for the detection and/or treatment of cancer at earlier stages. The possible use of cell competition as a tool for cell replacement will also be pursued. We expe