RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Neural mechanisms of spectral context effects on auditory processing' under Horizon 2020.

assistant: **Concept**

We perceive the outside world through different senses which we see as recording devices that provide us an accurate representation of reality. Nevertheless, how a sound is heard or a light is seen depends on the context in which they occur. How well we understand speech can greatly vary depending on the presence of other sounds. For instance, a single tone in a complex sound mixture can pop out if it is preceded by a sound with certain properties. This effect is thought to be fundamental in helping people to efficiently detect novelty in a stream of acoustical information. In other situations our perception can fool us, like when we hear sounds that are not there. Someone will perceive a phantom tone after having listened to a certain synthesized stimulus. This phenomenon is related to tinnitus -the perception of a permanent sound, a pathology that debilitates 2% of the population. While those effects are well documented in human psychology, where and how they originate in the brain is currently not known. Our goal is to perform in vivo intra-cellular recordings in the mammalian auditory system to seek the neural mechanisms underlying the effects of context in auditory processing. Beside the fundamental importance of relating perception to neural processing, this research could lead to a better understanding of the mechanism underlying tinnitus induction.Advancing the knowledge on brain processing is critical for European excellence. The results could serve medical research, a priority for the EU. The main research training objective is managing the challenging technique of patch clamp in vivo in which the host lab has expertise. This top-notch technique will complete the applicant’s scientific armentarium and make him very competitive in the multidisciplinary field of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Conferences for the Future of FET' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

COFET aims at supporting the future development of the FET programme based on a focused dialogue between science, policy, industry, and society. FET Future will realize a set of conferences and workshops addressing current and forthcoming challenges for interdisciplinary, ICT-related visionary research as exemplified in the FET programme of the EU's Framework Programme.<br/>COFET aims to address challenges such as the relation of FET research to innovation and competitiveness; the question of reaching out to a broad public; but also cooperation with the Member States in Horizon 2020.<br/>The project will support a minimum of three conferences with preceding workshops addressing these topics in a complementary fashion with different emphasis given to target stakeholders such as researchers in ICT and other fields, research policy makers, EC officials, industry and innovators, young scientists and students.<br/>COFET particularly aims at impacting on national and European research policy decision makers to secure their support in the form of policies, programmes, instruments and funding. It will assist the design of the future of FET to continue and further expand its success from FP5 to Horizon 2020.<br/>COFET will build on previous knowledge acquired in extensive studies and projects. The FET Future team includes ICT research strategists, experienced conference organisers, RTD policy makers and communication experts. FET Future activities will help to reach out to broad audiences while at the same time sharpening the profile as required for the changing role of FET in the future of EU level future and emerging technology research.<br/>
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Comparative Reconstruction of Ape and Hominin Locomotor ontogeny' (CRAHL) under Horizon Europe.

assistant: **Objectives**

Of all the traits that define humans, bipedal locomotion likely evolved first. How and why bipedalism evolved in the fossil human (hominin) lineage are fundamental questions in palaeoanthropology. An underexplored dimension of “how” bipedalism evolved is its growth and development (ontogeny). Humans locomotion develops much slower than those of other apes. Modern humans are also fully terrestrial, while the other African apes transition from predominantly arboreal locomotion using their upper limbs as juveniles to predominantly terrestrial knuckle-walking as adults. The importance of arboreal locomotion throughout hominin evolution has remained debated since the 1980s. However, since all extant apes are most arboreal as juveniles, the answers to this debate are most likely found in juvenile hominins.We know little about hominin locomotor ontogeny and the behaviour of juveniles due to (1) a lack of fossils and (2) limited tools for behavioural reconstruction. CRAHL applies recent methodological advances to both well-studied and newly discovered fossils to overcome these limitations, and will be the first to investigate the evolutionary pattern of hominin locomotor development. Bones can dynamically adapt to changes in loading direction, magnitude, and frequency by altering the structure of trabecular bone, the 3D mesh-like structure found underneath joint surfaces. Trabecular structure can therefore provide a functional record of developmental variation in loading conditions as animals learn to locomote. By using state-of-the-art methods for analysing age-related changes in trabecular bone structure throughout the skeleton, CRAHL will reconstruct how quickly hominins learned to locomote and the variety of postures they assumed, including arboreal versus terrestrial locom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced nanomaterials to target genomic and Z-DNA for bacterial biofilm eradication' (BactEradiX).

assistant: **Innovation**

BactEradiX aims to develop the first-in-class advanced antimicrobial nanomaterial to target biofilm Z-DNA and genomic DNA, to eradicate biofilm and resolve chronic/recalcitrant infections. Infective diseases and antimicrobial resistance are a threat to global health and development. Biofilm formation is a major cause of treatment failure, infection recurrence and acquired resistance development. WHO has declared antimicrobial resistance one of the top 10 global public health threats facing humanity. Infective diseases are an increasingly dramatic problem because the development of new antimicrobials is being slowed down dramatically and drug-resistant bacteria are growing. BactEradiX addresses this urgent global threat by leveraging breakthrough discoveries and advanced lipid-based nanocarrier technologies to target Z-DNA to destabilize the biofilm and to cleave bacterial genomic DNA to kill bacteria. The project seeks to overcome the challenges posed by bacteria in biofilms and the slow pace of development of new antimicrobial strategies. BactEradiX aims at developing a modular and tunable antimicrobial nanoplatform by focusing on two WHO priority bacterial strains: methicillin-resistant S. aureus (MRSA) and multidrug resistant P. aeruginosa. Our specific goals include: (1) characterization of structural Z-DNA in biofilms, (2) design of Z-DNA targeting PNAs for (3) lipid nanoparticles decoration to target and destabilize the biofilm, (4) design and develop antimicrobial anti-gene PNAs able to cleave genomic DNA and block bacterial replication (leading to bacterial death), and (5) validation of tailorable advanced nanomaterial for biofilm eradication: functionality and biocompatibility. The long-term vision of BactEradiX project is to develop the first-in-class modular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'UNDERSTANDING TRITROPHIC INTERACTIONS: PLANT-MICROBE-INSECT. ITS IMPLICATION ON INTEGRATED PLANT PROTECTION AND BIOLOGICAL NITROGEN FIXATION OF LEGUMES' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Biological nitrogen fixation (BNF) is one of the key agroecosystem services provided by legumes. Legume crops have a positive impact on the atmosphere and soil quality: i) by lowering emissions of greenhouse gases compared with other crops grown under mineral fertilisation and ii) by supporting BNF to the following crop when grown as components of crop rotations. This results in cost savings on synthetic fertilisers and fossil energy inputs in the system and on tillage, due to improved soil structure. However, factors such as insect attack, foliar disease and root microbial infection have a direct or indirect influence in reducing nitrogen fixation capacity and yield. Therefore, control of root-feeding organisms is essential for maximisation of nitrogen uptake by legumes. Conventionally, agrochemicals have been used to protect legume crops from pest and diseases, but their indiscriminate use has resulted in pest resistance and secondary pest resurgence, and they are detrimental to beneficial organisms for crop defence. The importance of driving reforms in response to the European commitment to sustainable agriculture and food production is directing my research interests towards a long-term mission that enables implementation of a new agricultural concept regarding food production that is safer for humans and the environment. The proposed project will use peas as a plant model to look for innovative strategies for reducing the dependence on chemical inputs, applying cutting edge technologies to leverage the use of beneficial soil microbes in the crop system. I suggest a pest management strategy to control nodule feeder insects by means of entompathogenic fungi (EPF). By exploring tritrophic interactions in plant-microbe-insect relations, this action seeks to evaluate wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Data Driven Digital Transformation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The D3T project goal is to demonstrate how a data-driven approach can innovate the Digital Transformation support scheme provided by Innovation Agencies such as Torino Wireless (TOWL).Digital Transformation (DT) allows SMEs to deeply change their business and organisational activities, processes, competencies and products/services by taking advantage of a mix of digital technologies. According to the EC, European companies are not taking full advantage of the advanced technologies or the innovative business models offered by the digital economy. Digital Transformation offers new business opportunities for SMEs and can fundamentally change business models, but it affects the whole value chain from product development to sales. It requires an enterprise-wide change which is driven by digital technologies.Currently, it is recognized a need for more efforts to provide a better support and highlight the need for DT within companies, thus creating a perfect opportunity for innovation support agencies to enhance and find new/improve ways to support firms in their DT paths, regardless of the sector they work in.Contextually, Data-driven is a trend that Clusters and innovation agencies can take advantage from to create value and enhance their operations, from the optimisation of the support services provided (support schemes) to the creation of more efficient services for their members and networks. Therefore, D3T project is focused in the improvement of a Digital Transformation support scheme by introducing a data-driven approach that allows a quicker and more thorough profiling and assessment of the companies’ needs in terms of digitalisation and how the support can be better implemented and managed. The data-driven approach will be based on a data analytics platform (D3 Platf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sequence of divisions 1-3 of the Drosophila genome' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objective of this proposal is to sequence about 4Mb of DNA, amounting to between 3-4 per cent of the Drosophila genome. This is to be seen as part of a larger strategy for the sequencing of the entire genome in a manner agreed between Drosophila laboratories in North America and Europe. Drosophila is a model multicellular eukaryote through which many conserved biological processes have been identified, particularly signal transduction pathways and developmental controls which are known to be operative in man. Thus a knowledge of the genetic makeup of this organism will be invaluable as a model system in which to elucidate the function and regulation of genes newly discovered in genome projects, including the human genome project. Furthermore, it will greatly enhance the utility of Drosophila as a model system in the direct development of control strategies aimed at a variety of agricultural pests and vectors of disease. The proposed work is based on a physical map of the Drosophila genome in the form of an ordered array of overlapping recombinant cosmids, constructed by an ongoing project initiated in 1988 with continued support from the European Community. Several hundred cosmids have been identified that correspond to the first three cytogenetic divisions of the X-chromosome. These fall into a set of 37 `contigs' that will be the basis for this sequencing project. The manner in which these cosmids were selected identified these contigs as sets of related overlapping clones, which will have to be converted into a linear physical array, before sequencing may be initiated. Gaps between cosmid contigs will be linked using other cosmid and P1 clones in a PCRbased strategy by the co-ordinating laboratory in Dundee. Cosmids will be distributed to five sequencing laborato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Gentrification processes and neighborhood liveability in Madrid and Brisbane: impact on population health and development of urban policy recommendations' in the context of a Horizon 2020 call.

assistant: **Objectives**

Where we live has a major impact on our health; indeed, 23% of global deaths are caused by modifiable environmental factors. The New Urban Agenda has inserted the ambition for liveable cities (those that promote active living and health of its citizens) as a priority to improve population health and wellbeing globally. However, liveability attributes carry a risk of ‘unintended consequences’ that can widen health inequities, especially when market-oriented regulatory processes and uneven dynamics of policy formation are at play. For instance, enhancing the liveability of a neighbourhood might increase housing prices and, in turn, provoke urban displacement of the most vulnerable, stimulating gentrification. Thus, the aim of the GentriHealth project is to generate policy-relevant evidence for the relationships between neighbourhood liveability, gentrification, and health. Specifically, the GentriHealth project has four objectives that seek to:1.Identify gentrification-related urban planning policies and legislation in Madrid, Spain2.Investigate the relationship between gentrification and changes in neighbourhood liveability3.Examine how gentrification impacts the health of ‘stayers’ and ‘movers’, and whether this differs by gender and socioeconomic status4.Work with policy-makers to develop policy-relevant solutions to reduce the potentially harmful effects of gentrificationThe GentriHealth project will be based at RMIT (Australia) and UAH (Spain). This project will use data on gentrification, liveability, and health from the HABITAT and the ERC-granted HeartHealthyHoods projects. This project will combine quantitative and qualitative data, mixed methods analysis ang GIS integration of data. Through a multidisciplinary approach and using a gender perspective, the GentriH
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Textile innovation environment in ACC' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

To enhance European dimension of the CC textile sector innovation it is necessary to encourage its wider participation in RTD programs. Regarding the capacity to cope with competitive pressure and market within the Union, the textile and clothing sectors in the CC have seen severe restructuring bringing considerable reduction in employment. Under situation, when the sector restructuring keeps advancing, it is necessary to encourage research and technology development of the sector, not least because of t he fact that one of their main competitive advantages - lower labour costs - is bound to decrease over time.Main aim of the ENVITEX project is to set up and implement textile sector partner search database that will contain appropriate information on researchers, research organizations and SMEs (interested in FP6 participation) in order to facilitate partner searching for the creation of consortia. In the interest of the data quality assurance the constituent part of project will be evaluation of complete innovative potential of textile sector in selected CCs.On basis of this analysis will be chosen according to predermined criteria the subjects suitable for participation in projects FP, which will be addressed with aim to find out their real interest in participation. At the interesting persons in participation ranged between SMEs will be accomplished the technological audit in order to identify real possibilities of the enterprise engagement in programs of research and development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ALTERNATIVE SPLICING NETWORKS IN PANCREATIC BETA CELLS' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Type 1 diabetes (T1D) is a chronic autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. The mechanisms by which autoimmunity is triggered and aggravated in T1D and the nature of the intracellular signals that decide beta cell fate between survival or death remain to be clarified. Alternative splicing (AS) is a complex mechanism of gene expression regulation and a potent generator of proteome diversity. It provides cells with an exquisite capacity to rapidly modify their transcriptome and proteome in response to intra and extracellular cues. AS affects more than 90% of human genes and has a major impact in many cellular processes, including cell survival and generation of new antigenic epitopes. There is a growing interest in the role of AS in autoimmune diseases but nearly nothing is known on its role in beta cells and diabetes. Recent findings by the host group indicate that pro-inflammatory cytokines change the expression of >30 RNA-binding proteins (RBPs) and modify AS of >3000 genes in human beta cells. Importantly, the host group has discovered that the diabetes candidate gene GLIS3 affects beta cell apoptosis by regulating the splicing of the pro-apoptotic BH3-only protein Bim. These findings suggest that AS plays an important role in the regulation of beta cell dysfunction and death by mechanisms that remain to be clarified. We hypothesise that pro-inflammatory signals activate splicing networks contributing to beta cell functional lost and death. We propose in the present project a systems biology approach that will combine RNA-seq, network inference and analysis of individual RBPs to characterize and validate inflammation-activated splicing networks in beta cells. The ultimate goal i