RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A global approach towards linking climate and marine biodiversity to ecosystem functioning' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Pelagic ecosystems play a fundamental role in modulating the global environment via their regulatory effects on the Earth’s climate and their role in biogeochemical cycling. Recent global climate change has refocused concerns about the potential effect of environmental change on pelagic communities such as changes in biodiversity or community composition that can alter ecosystem properties and the goods and services they provide. Therefore, biodiversity-ecosystem functioning research in marine systems is urgently needed at a time when the pelagic realm is known to be responding to climate change, especially for key trophic groups. The aims of this project are 1) to investigate geographic co-variations in copepod species diversity and the mean community body size structure at a global scale and their effects on carbon export, 2) to integrate these global diversity patterns across different trophic levels (from phytoplankton to fish), 3) to evaluate the influence of climate and environment on global marine biodiversity and the carbon cycle, and 4) to forecast potential shifts in distribution of pelagic biodiversity under different climate change scenarios to predict future changes in ecosystem functioning and ecosystem services. For the data analysis, cutting edge statistical modelling techniques will be used to evaluate the spatial distribution of a species, together with changes in biodiversity and ecosystem function under different climate change scenarios. The results of this study will enable, for the first time, to assess the relationships between pelagic biodiversity, mean community size structure and the functioning of the ecosystems at a global scale and as a consequence yield a key insight to how climate-induced effects in the plankton may affect global carbon c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Workshop on creation of biopharmaceutical development platforms with involvement of biotech SMEs' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Today, development of medicines in Europe is not optimal, most clearly demonstrated by the movement of workplaces to the USA. Outdated development and approval procedures, as well as weak ties between key players within industry, academia and regulatory authorities, also pose major barriers to pharmaceutical progress - to the detriment of patients suffering from illness and disease and the competitive ability of European industry. This contrasts to the fact that modern scientific knowledge and technologies present a realm of opportunities for the drug development process to cultivate new, safe and effective medicines. To reverse this situation, new technological platforms and organizational initiatives are needed for a concerted, continuous pan-European effort, involving all stakeholders in the highly complex drug development process. In this project, compriding a high-level workshop and a further exploitation period, followed by a final report, these aspects will be dealt with and solutions sought in a European context, with representatives from organizations representing all major stakeholders of the process with emphasis on biotech SME's. To secure that the conclusions drawn at the workshop will be disseminated and further exploited towards an operational level, there is the post-workshop activity, limited in time, with an Exploitation Secretary/Platform Ambassador"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Metal powder coating system with nano-technology pre-treatment.' (PreNANOCOAT) under Horizon 2020.

assistant: **Objectives**

preNANOCOAT presents a new innovative metal powder coating system for metal tubes manufacturing industry. Metal tube´s  coating is a major issue, since tube´s performance depends on its perfect coating. ANDERLINI MECCANICA SRL presents a new system for the coating of its tubes, with an innovative approach that includes a newly developed nano-technology pre-treatment, IR/UV curing and a specillay designed gripping device that, altogether with a compeltely automated process, ensures both the quality of the coatings as the best possible environmental techniques. Standard coating systems use dangerous substances such as phosphates and chromates, generating also important amounts of hazardous sludge that needs waste treatment process. Estándar curing ovens are big and demand enormous amounts of energy, as standard curing time of the tubes is never inferior to 20 minutes.Our new innovative system avoids the use of phosphates and chromates and generates no sludge at all. By the use of IR/UV curing mechanisms, necessary curing time is reduced to just 3 minutes, with the consequent save in enery resources.Finally, with our specially designed gripping deviced, soon to be patented, and our completeley automated conveyor, we will ensure proper health and safety conditions for our workers, which is not always taking into account in most powder coating facilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Epigenome maintenance in response to DNA damage'.

assistant: **Innovation**

Cell viability and homeostasis rely on the stable maintenance of the epigenetic information conveyed by chromatin, which associates DNA and histone proteins in the cell nucleus and governs gene expression programs. Yet, epigenome integrity is challenged during all DNA transactions, including DNA damage repair. While much effort has been devoted to characterizing chromatin alterations in response to DNA damage and how they contribute to the repair response, our knowledge of this fundamental process is largely incomplete, and whether and how epigenetic features are re-established following a genotoxic stress challenge is still unexplored. Thus, a comprehensive framework of the mechanisms underlying the maintenance of epigenome integrity in response to DNA damage is lacking. The present project aims to fill this important gap by profiling the epigenome of repair patches following UVC damage in human cells and by characterizing the molecular players contributing to chromatin restoration/plasticity. I propose an integrated approach that tackles this question at different levels of chromatin organization, from histone and DNA modifications up to higher-order chromatin folding. Building on our unique expertise and through the development of powerful novel methodologies, combining cutting-edge imaging, proteomics and epigenomic technologies, we will elucidate mechanisms for (1) histone modification re-establishment and maintenance and (2) DNA methylation inheritance at repair sites. We will also investigate how repair-associated changes in DNA and histone modifications reflect at the level of (3) higher-order chromatin organization in the tridimensional nuclear space, and dissect (4) functional crosstalks between the epigenetic changes that arise in damaged chromatin. This ambi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A comprehensive approach to the genetics of insulin-dependent diabetes mellitus (IDDM): understanding the role of genes and their products in the pathogenesis and development of complications in IDDM' under Fourth Framework.

assistant: **Concept**

- To identify and functionally characterise the genes responsible for insulin-dependent diabetes mellitus (IDDM) and its complications in man in order : - To fully understand, at the molecular level, the complex pathogenetic processes leading to beta-cell destruction and eventually to IDDM and the development of complications. The ultimate goal is : - To design new rational preventive/curative strategies for the treatment of IDDM and its complications.IDDM is a serious health problem in Europe and a costly one. The cumulative incidence rate of IDDM (0-90 years) is about 1.0 per cent, and the incidence rates of IDDM in the EU Member States have increased at least 2 to 3 fold over the last 4 decades. The direct and indirect costs of the diabetes problem (IDDM and NIDDM) in the European Union can be estimated at approximately 200 million ECU/million inhabitants/year. IDDM is amongst the leading causes of blindness, and diabetes is the largest contributor to dialysis - and renal transplantation programmes globally, and 25-30 per cent of lower limb amputations are performed on the 2-3 per cent diabetes in the populations. Thus, IDDM is a devastating disease carrying a heavy burden of reduced quality and quantity of life. Research over the last 20 years has made it clear that understanding in detail the processes leading to beta-cell destruction and IDDM and how each element is under genetic control is the key to the design of new treatments aimed at the disease process as such. Know-how and technology from modern immunology, cell biology and molecular genetics (the human genome project in particular) make the characterisation of the genetic and molecular mechanisms of the pathogenesis of IDDM possible in unprecedented detail. The collection of sera and DNA from very large, p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Bioaccumulation and distribution pattern of persistent organic pollutants in the Pilica River basin: An ecohydrology approach'.

assistant: **Innovation**

The goals of the proposed interdisciplinary project in environmental chemistry and ecohydrology are focused on linking functional interrelations between bioaccumulation of persistent organic pollutants (POPs) in biota and factors governing that process at a catchment scale. The dynamics of POPs within aquatic systems and their accumulation in the biota is driven, in general, by sources and loads and complex physical and biological processes. In river systems, the contaminant dynamics and bioaccumulation is greatly related to hydrology, sediment re-suspension and transport, in addition to the biotic factors such as feeding ecology and food chain structure.A set of field sites will be selected along the corridor of the Pilica River that vary in the contamination level, hydrology and catchment land use, for analysis of POPs. The sediment, suspended particles, water and biota will be analysed for PCB and selected dioxin and furan levels and congener patterns. The proposed research will demonstrate that an understanding of the hydrological, chemical and biological determinants of bioaccumulation at a catchment scale will improve the ability to model and predict bioaccumulation of POPs and will provide ecologically sound foundations for designing effective management strategies for sustainable water ecosystems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unravelling the mode of action of mucosal adjuvants' (MucoVac).

assistant: **Concept**

The development of new vaccines against infectious diseases is a major worldwide public health objective. Despite the availability of antimicrobial therapies, vaccines still constitute the most effective means of controlling infections. Adjuvants are crucial for increasing the onset, magnitude, diversity and memory of immune responses to vaccines. Whereas a range of adjuvants is available for conventional vaccination routes, there are currently no mucosal adjuvants for promoting the neutralization of respiratory, gastrointestinal or urogenital infections at the pathogens' port of entry. This proposal will focus on (i) performing innovative research on mucosal adjuvants' mode of action and (ii) catalysing the mid-term development of novel, safe, efficient vaccines for nasal or oral administration.Adjuvants that specifically target Toll-like receptors are efficacious in mucosal vaccination because they trigger mucosal immunity (including secretory antibodies). The host laboratory has a longstanding research programme on the mucosal adjuvant activity of a Toll-like receptor 5 agonist (namely flagellin). Recent results have suggested that cross talk between epithelial cells and mucosal dendritic cells drives flagellin's adjuvant activity. The present project aims at identifying (i) signals from flagellin-stimulated epithelial cells that are of paramount importance in the transactivation of dendritic cells, (ii) dendritic cell factors that condition T and B lymphocytes to produce specific mucosal immune responses, and (iii) unique features of memory responses in the mucosa. This proposal will provide unprecedented opportunities for characterizing mucosal adjuvants. Moreover, better knowledge of the mechanism underlying flagellin's action would not only shed light on the latt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TFF2 production and molecular mechanism studies to support new therapeutic approaches for gut diseases.' under Horizon Europe.

assistant: **Concept**

Inflammatory bowel diseases (IBD) are chronic gastrointestinal (GI) conditions, which affect approximately 1.3 and 2 million people in Europe and North America, respectively, with a growing number of incidences in Asia as well. Currently, existing therapies only alleviate the symptoms and suppress the inflammation, but dont promote gut repair. The development of novel therapies is limited by a lack of understanding of the underlying processes of gut healing and repair. Although trefoil family factors (TFF) are major players in gut epithelium restitution and repair, very little is known about their molecular mechanisms and interaction partners. In this project, I will attempt to close this knowledge gap and will focus on trefoil family factor 2 (TFF2). The proposed project aims to identify TFF2 interaction partners (i), study their structure-activity relationships (ii) and produce TFF2-based peptidomimetics (iii). I will use chemical synthesis coupled with structure elucidation to design and produce TFF2 photoactivatable probes for the identification of TFF2 interaction partners. Then structure-activity relationship studies of TFF2 and identified partners will be carried out to define structural determinants of binding and activity. Based on this knowledge I will design novel TFF2-based peptidomimetics and study their stability, binding to TFF2 targets, and effect on epithelial restitution. The proposed project will deliver fundamental insights into molecular mechanisms of gut healing and yield a set of novel peptidomimetics, which could serve as leads for further development of therapies for IBD and GI conditions.


**Keywords:** Inflammatory bowel diseases, trefoil family factors, peptidomimetics, NMR spectroscopy, target identification, photoactivatable cross-linking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Modulating ice nucleation and growth with bio-inspired protein-polymers for cryopreservation'.

assistant: **Objectives**

Efficient, non-toxic cryoprotectants, that allow long-term storage of viable therapeutic cells and tissues, are the tool that regenerative medicine requires for its successful realization into a viable therapeutic option. A remarkable class of biopolymers known as ice-binding proteins (IBPs) alleviate the risk of freeze injury throughout the Kingdoms of Life by keeping the nucleation and growth of ice crystals in check. Yet, the application potential of IBP analogues (IBPAs) as cryoprotectants has remained underexploited. This is because we are yet to unravel and utilize the structure-function relations, which govern the activity of IBPAs as inhibitors of ice recrystallization and promoters of ice nucleation at the single-molecule level in vitro and within a complex biological environment. I propose to develop uniquely modular IBPAs to perform the quantitative single-molecule and physico-chemical experiments essential to bridge this knowledge gap and to engineer ice-binders optimized for cryopreservation. Our first aim is the biosynthesis of a novel class of ice-binding protein-polymers (iPP) with systematic variations in composition and size. Ice nucleators with a broad range of sizes will be created from iPPs of variable chain length by dissolution, self-assembly and surface-tethering to nanoparticles of variable dimensions. Super-resolution microscopy experiments of iPP ice-binding will deliver high-resolution maps of spatiotemporal distribution and dynamics. These will be related to iPP structure, physico-chemical properties, ice recrystallization inhibition (IRI) and ice nucleation (IN) activity. These insights will translate into the next generation of bioactive iPPs tailored to maximize both IRI and IN. Their impact on heart cell and tissue cryopreservation will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dust and gas in planet forming discs'.

assistant: **Concept**

Planet formation is a widespread by-product of the process of star formation itself and occurs within relatively thin and dense protostellar discs made of gas and dust that orbit the newborn star. Such discs can now be probed with unprecedented detail thanks to high resolution telescopes and instruments, such as the Atacama Large Millimeter Array (ALMA) at sub-millimeter wavelegths or the SPHERE instrument at the Very large telescope (VLT) in the near infrared, which are both capable of probing nearby star formation regions with a spatial resolution of a few astronomical units.The overall aim of this project is to to strengthen the collaboration of groups located in Europe, USA, Chile and Australia - many of them already collaborating actively - in order to (1) develop and use suitable numerical algorithms and techniques to address key unsolved issues related to the interaction of newborn planets with the gas and dust environment in which they are born and (2) to compare such models with the most advanced observations of protostellar discs, obtained with high resolution telescopes in the IR and sub-mm.


**Keywords:** Plant formation, accretion disks, protoplantary disks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Membrane anaerobic reactor system' (1998-2002).

assistant: **Innovation**

In the field of municipal wastewater treatment, many different processes have been developed, but the usual treatment processes are based on an aerobic activated sludge process. The major drawback of such a system is the high energy demand for aeration, large space requirements and high sludge generation. Hence, operation of these systems is expensive and no substantial 'return on investment' ohm any added-value product is generated. The objective of this project is to combine anaerobic treatment with membrane bioreactor technology into an innovative system for the efficient and economic production of biogas from sewage in small and medium-scaled process units. To maximise the late time of the membranes by continuous and carefully cleaning without any additional detergent a supersonic based technology shall be developed and integrated into the reactor design.