RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated Spectroscopy for Protein Analysis Using Metasurfaces and Interband/Quantum Cascade Devices' (PROTEMIC).

assistant: **Innovation**

Proteins are the fundamental building blocks of life and are complex biopolymers. The pharmaceutical industry and medicine have an unmet requirement for dynamic, insitu monitoring of structural changes of proteins. Proteins may incorrectly fold during the expression process, or denature in response to changes in temperature, pH amongst others. These deviations lead to loss of function, loss of therapeutic effectiveness, increased immunogenicity or reduced product shelf life. For example, growing amounts of human milk are donated to serve the needs of pre-term infants but there is a lack of quality control to monitor protein quality during pasteurisation and storage. Current analysis techniques require extracting samples from the reaction vessel, which risks contamination, or use indirect measurements of the protein structure.PROTEMIC is a Double Doctorate Training Network that brings together the disciplines of Physics, Analytical Chemistry and Biochemistry to determine the protein structure from the sample’s Mid Infrared absorption spectrum without the use of labels or reagents. PROTEMIC builds on the team’s experiences with the successful OPTAPHI joint doctoral network and embeds the Doctoral Candidates into multiple disciplines to gain skills that cannot be obtained from a single host, and master biochemistry and spectroscopy. The project builds and expands on breakthroughs recently made in the OPTAPHI project, for example new photonic integrated circuits and world first photothermal spectroscopy results. PROTEMIC embeds metasurface and photonic integrated circuits into the reaction vessel to provide insitu mid IR spectroscopy for the first time and map structural changes during dynamic reactions in realtime. These results will improve the efficiency of the productio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrated small scale solar heating and cooling systems for a sustainable air-conditioning of buildings' (SOLERA).

assistant: **Concept**

The project aims to develop highly integrated solar heating and cooling systems for small and medium capacity applications which are easily installed and economically and socially sustainable. The envisioned applications are residential houses, small office buildings and hotels. The goal is to use the excess solar heat in summer to power a thermally driven cooling process in order to provide cooling for air-conditioning. In the heating season the solar system is used to provide direct heating. The proposed project therefore aims to demonstrate the technical feasibility, reliability and cost effectiveness of these systems, specially conceived as integrated systems to be offered on the market as complete packages which will make better use of the available solar radiation as present systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PROPEL ENERGY EFFICIENCY FINANCE' to be submitted under Horizon 2020.

assistant: **Abstract**

The potential for mainstreaming energy efficiency financing will be addressed by the PROPEL consortium by creating a single, holistic resource centre in Europe, which will be maintained and has ALL the critical collateral and resources required to develop, sell, contract and finance sustainable energy projects at the required scale.  The PROPEL project will build on the consortium’s significant ownership of, and access to, the full range of necessary standardised financing collateral, to deploy this collateral in the market while at the same time, firmly establish an industry association, the Sustainable Energy Finance Association (SEFA), which will act as THE knowledge and resource centre for the mainstreaming of finance into sustainable energy assets, not only during the project’s lifetime but long after its completion.  The PROPEL project will develop an integrated ecosystem of financing collateral and relevant actors, which together will drive the market for sustainable energy assets forward. PROPEL will focus on building and testing this ecosystem in four countries (Belgium, Greece, Italy, Netherlands), reaching out to a minimum of 400 EE projects developers (supply side), 50 end-client representatives (demand side), and 30 financiers (banks and financial funds).  PROPEL is expected to trigger €20M of investments into EE Projects within the project duration, leading to 40,46 GWh of annual primary energy savings and 10’890 tCO2 savings. These impacts are estimated to grow 25 fold within the 5 years after the project, due to PROPEL’s aim at creating a long-lasting eco-system, which will be hosted by SEFA.  The PROPEL consortium has a wealth of expertise in developing standardised collateral and putting together the building blocks for development of a single ecosyste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Resource Conservative Manufacturing- transforming waste into high value resource through closed-loop product systems' to be submitted under Seventh Framework.

assistant: **Abstract**

In a world with growing pressures on resources and the environment, the EU has no choice but to go for the transition to a resource-efficient and ultimately regenerative circular economy. The main objective of the ResCoM project is to develop an innovative framework and a collaborative software platform for the industrial implementation of closed-loop manufacturing systems.In ResCoM, four manufacturers who are active in B2B and B2C markets (Gorenje, tedrive, Bugaboo and Loewe) will pilot a closed loop product system in their businesses. These pilots will demonstrate how the collecting, remanufacturing and upcycling of discarded products into new added-value products will be cost-effective, resource-efficient and more sustainable than the current linear manufacturing systems.To support the pilot development, the ResCoM consortium will develop a framework based on methodologies and tools that take in account the complex, dynamic interation between product design (design for multiple product lifecycles), supply chain management (integrated supply chains), business model development (closed-loop business models) and remanufacturing processes .To support the pilot operations, the ResCoM consortium will develop a software platform consisting of a closed-loop product lifecycle management module coupled with a materials information module. The platform will help guide design decisions by illustrating the benefits of closed loop product design in terms of resource efficiency, CO2 production and energy use, and will provide business metrics such as lifecycle cost estimates, rapid identification of critical materials, product specific and remanufacturing considerations and legislative requirements. The platform will be tested and evaluated by the manufacturers.The ResCoM project r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combining protein engineering, biochemical and genetic approaches to dissect Par-1 function and regulation in vivo.' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The establishment and maintenance of cell polarity is a fundamental feature of most eukaryotic cells and is crucial for the generation of cell diversity through asymmetric cell divisions in development and for the proper execution of vectorial cellular fun ctions. Par-1 kinases play instrumental roles in cell polarization from yeast to humans. However, little is known about the molecular mechanisms by which they exert their effects. The Drosophila oocyte, which is ideally suited for genetic and biochemical m anipulation, will be used as a model system to identify and characterize Par-1 targets and regulators. Specifically, a proteomic-level screen will be applied to identify Par-1 targets. In parallel, candidate molecules likely to regulate or effect Par-1 fun ctions will be examined. Finally, new tools, including Par-1 activity sensors, will be developed to monitor Par-1 regulation in vivo. Given the molecular and functional conservation of Par-1 in eukaryotes, it is likely that interacting partners isolated in Drosophila will have similar functions in other organisms, providing insight into the molecular networks through which a fundamental process such as cell polarization is achieved. The host laboratory has extensive expertise both in doing state-of-the-art Drosophila genetics, as well as in developing and exploiting new approaches, demonstrated by multiple publications in top-tier journals. Furthermore, the interdisciplinary and highly interactive environment at EMBL, as well as its state-of the-art Core Fac ilities, provide a unique opportunity for receiving high-level training and doing cutting edge research in Molecular Biology. EMBL also offers great possibilities for collaborations and networking with scientists world-wide, contributing to the enhancement of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Investigating Increases in Global Terrestrial Carbon Uptake During the Last Three Decades' (IRACCS), addressing dissemination and exploitation.

assistant: **Impact**

Since anthropogenic CO2 is the most important long-lived greenhouse gas causing climate change, improved understanding on how it cycles between the active land, ocean, and atmospheric reservoirs is a main concern for humanity. During the past decade, annual fossil fuel CO2 emissions have sharply increased at a rate of 3%/yr, almost doubling the rate of the prior three decades. To a big surprise, the corresponding increases in atmospheric carbon dioxide concentrations were relatively modest during this time frame. This coincidence has led to the hypothesis that the sharp rise in fossil fuel emissions and increase in sink strength especially since early 2000 may be a result of carbon sink processes that are controlled by the increasing emissions themselves, namely increased nitrogen deposition and a larger fraction of diffuse versus direct solar radiation from increased sulfate aerosol emissions.The objective of the proposed work is to estimate changes in global terrestrial carbon uptake over the last decades and attribute their cause(s) through a combination of observation-based and modelling approaches. We will investigate three main hypotheses in regards to increased terrestrial carbon uptake during recent decades, including (i) a progressive relaxation of climatic constraints on plant productivity including warming in northern temperate, boreal and tundra ecosystems and increases in rainfall rates over tropical savannas, (ii) increases in the fraction of diffuse/direct radiation associated predominantly with East Asian sulfate aerosol emissions that spurred plant photosynthetic rates, and (iii) increases in nitrogen deposition from East Asian fossil fuel burning that increased carbon plant uptake.This research is designed to improve our knowledge about carbon cycle fe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrophilic aromatic substitution of azines catalysed by Frustrated Lewis pairs' in the context of a Horizon 2020 call.

assistant: **Objectives**

Azines are nitrogen-containing aromatic rings of utmost synthetic relevance in  natural products, pharmaceuticals, agrochemicals and materials science. Although nucleophilic aromatic substitution techniques are routine, these methods require air-sensitive and highly reactive nucleophiles, in most instances organometallic reagents. In sharp contrast, electrophilic aromatic substitutions are particularly difficult to the electron-poor nature of the azines, inevitably requiring harsh reaction conditions. Taking into consideration the wider availability of electrophilic partners when compared to their corresponding nucleophilic congerener, the development of a catalytic technique aimed at providing a mild, chemoselective and site-selective electrophilic aromatic substitution of azines will have tremendous consequences for the praxis of heterocyclic chemistry, particularly in late-stage applications. Aimed at providing a solution to such goal, LEWIS-PYR will design a conceptually new platform to activate unbiased azines via electrophilic aromatic substitution by using frustrated Lewis Pairs (FLPs) as a polarity inversion vehicles, allowing to substitute a series of a priori electron-poor nitrogen-containing electrocycles with a wide variety of different electrophilic partners.


**Keywords:** frustrated Lewis pair, azines, electrophilic substitution reaction, Lewis acid, Lewis base
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Characterising the Energy Landscape of Nano-Polymer-Aggregates:Application to Synthetic and Bio-polymers' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The proposed project will develop and apply new theoretical and computational methodologies to study (bio)polymers and (bio)polymer aggregates. The techniques involved focus upon the underlying potential energy landscape and use global optimisation to loca te low-lying minima, and calculation of thermodynamic and dynamic properties using databases of stationary points. Polymer energy landscapes are especially difficult to treat using conventional methods (e.g. molecular dynamics, Monte Carlo) as they featur e vast numbers of local minima, broken ergodicity, and long relaxation times compared to those accessible by standard simulations. Broken ergodicity and slow relaxation issues are caused by experimentally relevant regions of configuration space being separ ated by high energy barriers, which although overcome on experimental time scales, are difficult to treat in simulations. The proposal would extend and generalise methods developed in the host group, which have been successfully applied to clusters and pep tides. The manifestation of the topology of the potential energy surface in observable dynamic/thermodynamic properties will be elucidated for polymer chains with various architectures (linear, ring, comb, dendrites) and for nano-aggregates of multiple cha ins. Aggregation of misfolded peptides is particularly important due to the implication of such structures in a growing variety of debilitating human diseases. There is an urgent need to understand such processes in more detail, especially the underlying g eneric structural principles. The host group has internationally recognised expertise, having introduced or developed many of the above methods. New developments in theory and software will be made available to other workers in the synthetic and biopolymer fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Late-stage C–H bond construction of cyclopropanes to impact drug discovery' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The cyclopropane ring is the 10th most commonly observed core in small-molecule drugs. This is due to the fact that cyclopropanes can positively influence metabolic stability, conformation, pKa, entropy, membrane permeability or pharmacokinetics in drug leads. The cyclopropane ring is often introduced in drug candidates at the early stages of the synthesis, however, the late-stage construction of multi-substituted cyclopropanes using C–H bonds as a functional group has not been developed yet. This concept promise to reach a “cyclopropanated” chemical space not possible by current strategies and that may impact how medicinal chemists will discover cyclopropane-based drugs that address unmet medical needs. LateCPC aims to develop an innovative technology to rapidly construct cyclopropanes from C–H bonds in feedstock and fine aromatic molecules as well as in complex drug molecules. Our approach will rely on the diazo activation of bespoke carbyne sources developed in the host group with metal catalysts, allowing the catalytic generation of metal-carbynoids. A key strength of this conceptually new and multidisciplinary proposal is the introduction of a secondment phase in Novartis (Basel) to explore real-life applications. The ambitious action merges perfectly the expertise of the host in novel C−H functionalization strategies based on the catalytic generation of innovative carbyne equivalents with the strong background of the applicant in metal-catalyzed Tsuji-Trost reactions, thus enhancing two-way transfer of knowledge between the ER and the host group. Successful development of this project will enable the ER to become a leader for the next generation in the field of chemical synthesis and late-stage functionalization techniques. The ER will be exposed to a wide range o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hial - biofuels for chp plants - reduced emissions and cost reduction in the combustion of high alkali biofuels (HIAL)' (HIAL).

assistant: **Innovation**

Objectives and problems to be solved:The scientific objective of this proposal is to understand the influence of fuel composition and combustion conditions on the release of alkali metals, S and Cl to the gas phase considering different combustion systems. The technical objective of this proposal is to apply the understanding of the alkali chemistry to develop primary measures for grate firing to achieve SO2 emissions below 200 mg/Nm3 without the need for installation of flue gas desulphurisation unit (FGD). This can be carried out by improved capture of SO2 in the bottom and fly ash by changing the operational parameters. Moreover, this understanding is the necessary prerequisite for a suppression of alkali induced corrosion attack allowing an increase in the reliability of operation and an increase of the straw share in co-combustion processes.Description of work:The work of the project is carried out in three work packages.In work package WP-1 (Sampling and characterisation) different kinds of straw from different European countries will be sampled and characterised by chemical and thermal analysis.In work package WP-2 (Combustion Chemistry and Release) the combustion chemistry and the release of alkali metals, S and Cl will be investigated. This work package is the main work package and it includes most of the experimental work. The release of the alkali metals, S and Cl will be investigated by bench scale experiments using modern mass spectrometric techniques and different kinds of combustion technique (fixed bed, fluidised-bed and suspension combustion) with and without coal co-combustion. The industrial partners of the project will give their experience based on the operation of full-scale power plants into this work package. The results obtained by fundamental m