RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Parasite-specific cyclic nucleotide phosphodiesterase inhibitors to target Neglected Parasitic Diseases' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD). It will establish a drug discovery platform, PDE4NPD, that combines phenotypic screening with efficient target-centric drug discovery, including target validation, various strategies for compound screening, PDE hit and lead optimization, safety and toxicology assessments and evaluation of anti-parasitic activity. The platform will make use of the target class expertise that the participating SMEs have gained when developing drugs for human and parasite PDEs, while all public partners offer proven experience in the field of NPD. The SMEs will adopt and progress existing PDE inhibitors that are in different stages of the drug discovery pipeline (i.e., target validation, hit and lead optimization). The current portfolio of  inhibitors have clinical potential for treating sleeping sickness, Chagas' disease and leishmaniasis. Finding novel hits and leads for the PDEs that are associated with helminth diseases is also foreseen. The platform is open for targeting other NPD, and a broad panel of phenotypic screens (including malaria) is available to test PDE inhibitors. The phenotypic screening is performed by world-renowned groups, including two institutes in endemic countries. By capturing human and parasite PDE-related data in annotated chemogenomics databases, PDE-4-NPD will achieve the knowledge accumulation that is typical for target-centric approaches, thereby making the NPD drug development more efficient and enabling the SMEs to take advantage of the molecular understanding that is key for developing new medicines. The PDE4NPD platform constitutes an ideal basis for creating fru
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'EEN Innovation Management Services Berlin-Brandenburg' under Horizon 2020.

assistant: **Concept**

Berlin Partner für Wirtschaft und Technologie GmbH (BP) and ZAB ZukunftsAgentur Brandenburg (ZAB), the two economic and technology development agencies of Berlin and Brandenburg, both partners in the Berlin-Brandenburg Enterprise Europe Network consortium, are going to offer innovation management consultancy to SMEs with high potential for innovation, internationalization and growth. This newly developed service will allow the agencies to broaden their service portfolio to SMEs und to support existing programmes for research and innovation. While the latter usually concentrate on technologies and other outputs, InnoManage BB 2015-2016 will focus an internal management processes and capacities in the SME in order for them to successfully innovate. Target groups of InnoManage BB 2015-2016 are a) companies which have successfully applied for funding under the SME Instrument of H2020, and b) other SMEs in Berlin and Brandenburg which show the potential for innovation, internationalization and growth. As both BP and ZAB have been responsible for realizing the innovation strategies of their respective federal states since more than ten years, both agencies are fully familiar with the scope and challenges fading innovation-orientated companies. Within the frame of this project, BP and ZAB intend to carry out 71 service packages in total, BP will take over 40 service packages, ZAB 31 service packages.


**Keywords:** Innovation, management, SME, H2020, SME instrument, SME coaching, innovation processes, management enhancement, innovation consultancy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A functional approach by t-dna tagging to isolate plant genes involved in salt tolerance' in the context of a Fourth Framework call.

assistant: **Objectives**

Saline stress in agricultural crops is a major challenge to plant biotechnology. Although a genetic background to stress tolerance exists in halophytes, this is not available to breeders of crop plants. An application of biotechnological advances requires the knowledge of target genes responsible of salt tolerance.  Previous work with the baker's yeast S.cerevisiae, has revealed the use of a 'functional approach', that is gene overexpression and selection of those activated genes which confer the expected phenotype, as a very efficient procedure to identify genes capable of increasing salt tolerance. Obviously, a straightforward advance would require the use of a similar 'functional approach' of overexpression and selection directly in plants. The recently designed T-DNA tagging procedure combined with protoplast cocultivation allows the isolation of screenable dominant mutations by overexpression of any particular gene which can be later rescued.  In the present project we propose utilize this innovative strategy with tobacco protoplasts to identify plant genes involved in salt tolerance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biomedical engineering for cancer and brain disease diagnosis and therapy development', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In the understanding of the initiation and development of several diseases revolutionary changes are currently taking place. Cancer and brain diseases are examples of medical fields where new technologies are finding their way into research and applications, radically altering the way the diseases are being diagnosed and treated. Especially methods that yield information on molecular and cellular mechanisms open up the way for novel effective therapies for disease prevention and disease curing.The aim of this ITN is to conduct training and research in the field of novel bio-analytical methods and tools for cell based diseases, in specific for severe cancers and brain diseases. These methods and tools should allow faster and more reliable diagnosis, but are also of great importance for therapy research leading to novel treatment methods. This ITN combines disciplines such as engineering, biotechnology, medicine, and chip-technology and the consortium covers universities, hospitals and industry. The functionality of the devices is determined by the type of measurements that need to be performed, therefore we will focus on a few specific diseases: our cancer research will be aimed at skin cancer (melanoma) and blood cancer (leukaemia), and the part on brain diseases will focus on schizophrenia. Although we will direct our activities towards these three diseases in particular, we expect that the research (methods, devices, and technology) will also have impact on the understanding of other cancer types and other brain diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Experimental introduction of configuration management in a project subjected to changes due to different users environments' (COMANCHE).

assistant: **Concept**

The development of software according to a total quality model is becoming fundamental for the success of a software company. For this reason Softwareuno intends to obtain the ISO 9001 certification. A fundamental step towards reaching the required degree of quality is the application of a sound configuration management methodology. This is particularly true when visual programming techniques are adopted, since the structure of a system is less linear than in the traditional approach. The introduction of a configuration management method will allow Softwareuno to achieve objectives like: decreased costs of the production, installation and maintenance of its products; a higher degree of safety and awareness in the process of change; a decreased number of errors due to a bad configuration of a software package; a greater degree of the customers' satisfaction; a greater control on the actual status of the product.THE EXPERIMENTThe achievement of the objectives above will be to obtain introducing a Configuration Management method with support of an existing tool (e.g. SourceSafe, ClearCase, CVS or Continuous).A constant control and support of all the activities related to the use of the Configuration Management procedures will be granted to the developers in order to obtain a correct and effective use of the tool. A series of statistical data will be gathered.The experiment is part of a greater software application called Ospiti, which consists in an integrated solution to the global management of old people's homes.Softwareuno employs 20 people, 10 of them are involved in the Ospiti project.EXPECTED IMPACT AND EXPERIENCEGreater speed in the updating of the products, costs saving due to less effort spent in Configuration Management activities, increased control on the statu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Targeting multidrug resistant cancer'.

assistant: **Innovation**

Although considerable progress has been made in treating cancer over the past decade, there are still over 8 million deaths annually from cancer worldwide. Despite considerable advances in drug discovery, resistance to chemotherapy confounds the effective treatment of cancer patients. Cancer cells can become resistant to a single drug or they may acquire broad cross-resistance to mechanistically and structurally unrelated drugs (multidrug resistance (MDR)). ATP-Binding Cassette (ABC) proteins comprise the largest protein family, many members of which are of immediate medical importance and relevant to human health. In particular, ABCB1 (MDR1-Pgp) actively extrudes many types of drugs from cancer cells, thereby conferring resistance to those agents. Thus, innate or acquired expression of P-gp is a major problem in cancer chemotherapy. The major challenge of the postgenomic era is to analyze vast amounts of data. In this context, the application of pharmacogenetics has the potential to improve the management of patients, particularly by providing the molecular basis for choosing among the increasing number of chemotherapeutic agents available for the treatment.The basic hypothesis of this proposal is that a pharmacogenomic approach can be exploited to discover MDR1-inverse compounds that selectively kill multidrug resistant cancer cells. The proposed research utilizes a complex array of methodological tools that involves diverse state of the art techniques, such as chemoinformatic algorithms, a custom-made microarray, and biochemical assays for measuring and characterizing transport. Accomplishing the outlined aims will provide the foundation for the detailed and comprehensive framework to verify the viability of the presented hypothesis. Together, the aims help in determ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Euroas European genomic bank and clinical, genetic and immunogenetic databases of ankylosing Spondylitys and the other Spondylarthropathes' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Existing infrastructures of partner laboratories and clinical leading centres in European countries will be harmonised and reinforced into a task force to achieve clinical (phenotypes), genetic material and genotype repository from anklylosing sodalities (AS) and the other spondylarthropathies (SPA), thanks to the access to up to 00 affected families. After diagnostic ascertaining, informative families will be recruited. All needed clinical data (including severity assessment, co morbidities) from AS patients and unaffected individuals will be collected. DNA, cells, sera and transformed cell lines (EBV) will be stored in a central bank for researcher use. Only such a large repository will give enough power to monogenetic, candidate gene, genome wide screen and fine gene mapping studies to successfully identify new AS susceptibility and severity genes, allowing the development of new therapeutic (gene therapy) and preventive approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advancing Gene Transfer Capabilities' (AGTC) targeting Horizon Europe.

assistant: **Abstract**

Innovation: We recently developed a targeted lipid nanopar We recently developed a targeted lipid nanoparticle (tLNP) that can insert a gene directly into the genome of T cells in vivo, with efficiency comparable to viral methods. This innovation creates a unique opportunity to track gene delivery using barcoded synthetic vectors. These barcodes help us understand the key factors needed for effective DNA delivery and the biological consequences of gene transfer.Background: Gene therapy holds great promise for treating various diseases. Viral vectors are currently the most common method for gene transfer, but they come with limitations like size restrictions on nucleic acids, triggering immune responses, and complicated production processes. Synthetic vectors like LNP have made significant strides, as shown by the success of mRNA COVID-19 vaccines, which demonstrate the efficacy, scalability and cost-effectiveness of LNP. However, LNP have struggled with efficient gene transfer. Improving this is challenging due to the vast nanomedicine design space and poor correlation between in vitro and in vivo results. Barcoding technology has revolutionized LNP design by allowing higher throughput screening, enabling comprehensive sampling of the design space in living organisms. To apply this to gene transfer, a working prototype is necessary. Our recent success with LNP-mediated gene transfer serves as this foundation for rational optimization of synthetic vectors using DNA-encoded peptide barcodes.Objectives: The AGTC project will explore three main research lines:1.Nanomedicine Design: Efficiently explore the design space to optimize LNP.2.Targeting: Investigate precision and flexibility of targeting, particularly in T cells.3.T Cell Biology: Link gene transfer to biological ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Breaking down aging phenomena in Resistive Plate Chambers operated with eco-friendly gas mixtures'.

assistant: **Objectives**

With the enforcement of EU regulations 2024/573, the production and usage of Tetrafluoroethane (R134a) has been strongly regulated. This gas is a key component in the gas mixture of Resistive Plate Chambers, a detector technology widely employed in high-energy physics. A potential, more environment-friendly, substitute for this gas is Tetrafluoropropene (HFO) and several promising HFO-based mixtures have been proposed. The long-term behavior (aging) of RPCs operated with these mixtures is typically studied by exposing several detectors flushed with an HFO-based gas mixture to a radioactive source and by studying the stability of the absorbed current and RPC performance over timeExperimental tests are crucial to spot and quantify aging effects, but can rarely provide an explanation for their origin. This requires a deeper understanding of the microscopical modifications of the materials induced by the HFO decomposition when exposed to irradiation. This project aims at breaking down the aging phenomena of several RPC components in their basic building blocks by comparing the chemical (EDX spectroscopy and SEM analyses) and electrical (resistivity) features of new and aged samples of RPC materials. The results of these analyses will be used to formulate a model to describe the observed effects and develop a simulation code, allowing for a systematic test of the aging properties of different HFO-based gas mixtures.I will carry out my research at the High Voltage Laboratory of the ETH Zurich University and at the Physics Department at the University of Torino, with the guidance of Prof. Christian Franck and Martino Gagliardi, leading experts on eco-friendly high-voltage gaseous insulation and RPC detectors respectively, while the chemical analyses will be performed at the CE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Encouragement to Advance - Training Seminars for Women Scientists' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The overall strategic objective of the proposal is to empower women scientists and to stimulate their participation in science and technological development. It is also designed to stimulate mobility and participation in the European Research Area (ERA).The proposal addresses women scientists who do not yet hold a leading position, e.g. as a full professor. In a four-day long international application and career training seminar highly qualified women scientists are prepared for appointment and application procedures for professorships in Austria, Belgium, the Netherlands, Switzerland and Germany.The countries have been selected because appointment procedures are very similar there. In particular, the seminar is meant to serve the following objectives:- Preparation for appointment procedures for leading positions at universities and research institutions of the involved countries through:getting acquainted with the specific forms of appointment procedures within the respective countriesreflecting the different scientific cultural communities- Development of career strategies and possibilities for strengthening one's own scientific profile, specifically in view of international research connections, by means of:information and exchange concerning participation in EU programsfocusing on aspects of international research cooperationthe possibility of individual career planning and of working out further career steps- Getting to know appointment procedures in neighbouring countries- Formation of a network among the participants continuing after the seminar ends and supporting female scientists at various career levels- Support for the further development of self-management skillsOne day of the seminar will be exclusively dedicated to meeting policy makers, European Commissi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of microRNAs in pancreatic islet dysfunction in type 2 diabetes mellitus' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Type 2 diabetes mellitus (T2DM) is caused by a relative inability of the endocrine pancreas to meet the increasing metabolic demands of insulin resistance associated with obesity and ageing.  Impaired insulin secretion is an early and critical step in the pathogenesis of type 2 diabetes, but the underlying mechanism of ß-cell loss and dysfunction in T2DM are incompletely understood. Recent studies have indicated a role for several microRNAs (miRNAs), a recently discovered class of evolutionarily conserved small noncoding RNAs that regulate gene expression at a posttranscriptional level. Specific expression of miRNAs in β-cells has been reported. However, little is known about the role of miRNAs in the pathogenesis of T2DM. Therefore, the overall objective of this grant proposal is to understand the role of miRNAs in ß-cell function, glucose and lipid metabolism and etiology of T2DM. We aim to determine whether miRNAs are involved in the loss of ß-cell function and ß-cell mass in T2DM and will investigate the potential of miRNAs as a therapeutic target in T2DM.First we will identify miRNAs that are differentially expressed in β-cells of normoglycemic, hyperglycemic and T2DM mice. We will next examine these differentially expressed miRNAs on their potential to dysregulate β-cell physiology in vitro. The impact of the promising miRNAs on β-cell function and β-cell mass will be assessed in C57Bl6 mice by overexpressing or silencing miRNA specifically in β-cells using AAV vectors. To determine the potential of miRNAs that affect β-cell development or function as therapeutic targets for T2DM, we will study these miRNAs in diabetic mice.This work will generate new knowledge about the role of miRNAs in ß-cell function, glucose metabolism and T2DM. This may point to new therapeu