RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Continuous Enzyme Evolution – solving bottlenecks in enzyme engineering to design next-generation biocatalysts' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Directed evolution has revolutionized the application of enzymes in industrial settings by allowing users to tailor the properties and activities of biocatalysts to their needs. But classic directed evolution is notoriously labor- and time-intensive, as it manually stages mutation, selection, and amplification cycles. In contrast, continuous evolution (CE) approaches aim to achieve these steps within a replicating organism, making it possible to engineer efficient enzymes in a matter of days rather than months or years. Unfortunately, current CE approaches are typically applicable only to model enzymes with little industrial value.To unleash the full potential of CE, we will develop a scalable, low-tech CE platform, which is readily applicable to biocatalysts that provide value-added products. Toward this end, we will merge a versatile selection system we recently developed with strategies to diversify the genes of targeted enzymes in vivo and an autonomous setup to grow bacterial populations continuously. Combined the resulting CE-platform will enable us to engineer biocatalysts along many and long evolutionary trajectories. Moreover, analyzing the fate of these populations by sequencing will allow us to map the sequence-structure-function relationships of these biocatalysts. Based on the systematic datasets generated in these efforts, we will train machine-learning (ML)-models to predict functional sequences. Lastly, in a ML-directed CE approach, we will establish a design-build-test-learn cycle to improve models and guide CEs toward promising, but otherwise inaccessible sequence spaces.Overall, ContiZymes will overcome unaddressed challenges associated with the application of biocatalysts that promote sought-after C-C, C-halogen, and C-N-bond forming reactions. We wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Bio- and environmental fluid mechanics'.

assistant: **Concept**

The FLUBIO single host EST project, located at the University of Genova, will provide outstanding research training in the field of basic and applied Fluid Mechanics to young researchers.Research/educational competences of the 9 members of the FLUBIO research team cover a wide spectrum of topics in Basic, Environmental and Biological Fluid Mechanics. The programme will initially run for 4 years and be rooted in a solid educational strategy blending classical fluid dynamics courses with modern complementary training activities.Research methods will be interdisciplinary and activities will focus on basic and applied fluid mechanics, including Coastal and Riverine Hydro-Morphodynamics (a subject where DIAM is a world leader) and Bio-Fluid Mechanics (an emerging topic within DIAM). FLUBIO foresees collaborations/synergies with industries, medical laboratories and environmental agencies.The 10 trainees (engineers, mathematicians, bio-ecologists, physicists), admitted on the basis of merit and potential, will be exposed to a research programme in which excellence is the rewarding factor. Monitoring/adjustment of the activities towards success of the programme will be made on the basis of Research and Training/Educational Achievements, Collaborations/Visibility, External Funding and Ethics.FLUBIO is very timely as it will serve the EU need to develop competencies in natural hazard/environmental management for use across platforms like the Green 9" and the EEP, it will provide support in Bio-Fluids topics related with Bio-Technologies and will spread the EU new competences thus contributing to the ERA.FLUBIO will establish a solid operative framework thus overcoming fragmentation as well as providing young researchers with pathway opportunities between academia and industry (th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Predicting outcomes of nature based solutions and river reconnection for endangered cold-water fishes in European rivers' (RESOLUTE).

assistant: **Concept**

Climate change and river fragmentation are interacting in Europe's rivers to drive population extinctions of cold-water fishes, including those of the Salmonidae family. The effects of extreme warming in summer can be mitigated by increasing the provision of cool-water refugia through nature based solutions (NBS) that provide salmonid fishes with optimal rather than critical temperatures. However, the fishes must be able to access these refugia, which can be difficult in highly fragmented rivers, unless fish pass engineering is applied to the barriers fragmenting the river. The beneficial interactions of NBS and fish pass engineering on salmonid populations are, however, unknown. While they could facilitate behavioural thermoregulation, where fish actively move from warm areas into cooler waters (often moving >10km), fish passes also impose considerable inter- and intra-specific selectivity of fishes, often only being passable of specific size ranges and behavioural phenotypes (e.g. proactive individuals with bold, exploratory behaviours). Consequently, mitigating for warming and river fragmentation using NBS and fish pass engineering could result in considerable modifications to the diversity and distribution of fish species and phenotypes in Europe's rivers. This project aims to overcome these considerable knowledge gaps on how NBS and fish pass engineering can act in concert to provide sustainability in cold-water fishes in warming and fragmented rivers. The complementarity of an outstanding researcher in applied fish ecology with a European research group with exceptional expertise in fish spatial and trophic ecology will complete an empirical study based on fish biotelemetry methods in a natural field experiment testing relevant hypotheses within four NBS/ fish pas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The impact of Intellectual Property Rights (IPRs) on the development of European biotechnology', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

This multi-centred research project (GB, FR) aims to assess the impact of intellectual property rights (IPR) on inter-firm research collaboration in the European biotechnology industry. The overall aim is to provide an analysis which identifies best practice in the management of IPR.The biotechnology industry poses major challenges for existing national and international IP regimes. It is relatively new, subject to rapid innovation and centrally concerned with knowledge production. Recently, considerable attention has been given to the implications of alternative modes of managing IP by large companies. However, there has been little investigation of how existing European IP regimes and enforcement mechanisms affect the innovative potential and competitiveness of European MNEs and SMEs. This project has two separate but inter-related components. The first is centrally concerned with the failure of the EU IP Directive to provide a harmonised IP regime in Europe. The second deals with how the existing regime affects the innovative potential and competitiveness of European firms in biotechnology in the context of inter-firm collaboration. There are five inter-related work packages. These aim: (a) to identify the critical steps in the evolution of the debate on the EU IPR Directive  and the main focal points of discussion underpinning them; (b) to establish the identity of the main actors in the process and to analyse the kind of  evidence used in support of their arguments; (c) to assess the importance of IPR as a barrier to inter-firm collaboration in different  sectors of the European biotechnology industry;(d) to examine the appropriation strategies of firms in allocating IP rights arising from  collaborative R&D and/or investment and (e) to identify the implications of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Unraveling the mechanisms of odor coding and sent-tracking in Drosophila larvae'.

assistant: **Innovation**

To survive and prosper, any motile organism must extract relevant cues from its external environment and convert them into coherent internal representations. Responses elicited by the flow of internal representations form the basis of adaptive behaviours. The overall goal of this project is to elucidate how olfactory signalling and behavioural decisions emerge from the integration of molecular and cellular interactions. Despite the relatively good anatomical characterisation of insect and vertebrate olfactory systems, little is known about the neural basis of odour percept formation and their processing in the brain. We will address this problem in the simple and genetically tractable system of the fruit fly (Drosophila melanogaster) larva. An odorant stimulus can be specified by three variables: odour quality, odour intensity and time of occurrence. To chemotax, larvae are able to reliably perceive and integrate changes relative to these variables by using noisy detectors. We aim at identifying and functionally characterising the peripheral and central neuronal circuits involved in larval chemotaxis. A cross-disciplinary approach will be adopted to combine the power of fly molecular genetics, state-of-the-art engineering, electrophysiology and computational modelling to determine: how odour intensity is represented by the peripheral sensory neurons; where intensities measured at different times are stored and subsequently compared and whether the design principles of the larval olfactory system allow noise filtering. Clarifying how an elementary nervous system solves these fundamental questions will increasing our understanding of the relationships between neuronal circuits in the brain and behaviour.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Agroforestry Innovation Networks (AFINET)' (AFINET) under Horizon 2020.

assistant: **Objectives**

Agroforestry (AF) is the practice of deliberately integrating woody vegetation (trees or shrubs) with crop and/or animal systems to benefit from the resulting ecological and economic interactions. Research activities developed by AFINET partners indicates that appropriate application of AF principles and practices is a key avenue to help the European Union to achieve more sustainable methods of food and fibre production, producing both profits for farmers and environmental benefits. However up to now exists a lack of AF knowledge among end-users that prevent the correct implementation of these practices.In this sense AFINET will act at EU level in order to take up research results into agricultural practice, improving knowledge exchange between scientists and practitioners on AF activities, with a special focus on silvoarable and silvopastoral systems design, management, and production and profitability. To achieve this objective AFINET consortium proposes an innovative methodology based on: (i) The creation of a EU reservoir of scientific and practical knowledge of AF with an end-user-friendly access (the “Knowledge Cloud”). (ii) The creation of a European Interregional network (composed of “Regional Agroforestry Innovation Networks” - RAINs) considering a multi-actor approach (including farmers, policy makers, advisory services, extension services, etc.), and articulated through the figure of the “Innovation Broker”. These RAINs groups will be interconnected in nine strategic regions of Europe from Spain, UK, Belgium, Portugal, Italy, Hungary, Poland, France and Finland, representing different climatic, geographical, social, and cultural conditions at European level.In addition, to create a greater user acceptance of the collected solutions and an intensive disseminat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Microwave Assisted Curing for Resin Transfer Moulding' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

MAC-RTM project aims to develop an alternative highly innovative microwave-assisted curing (MAC) technology for thermoset materials with improved flexibility and more cost and energy effective than current curing technologies.The MAC technology will be developed and adapted to the Resin Transfer Moulding (RTM) and RTM-Light industries for composites production.The challenging MAC-RTM technology will be optimised through simulation of the microwave-resin interaction. Curing control and sensor systems will also be developed to guarantee a cost-efficient, controlled and reproducible curing process.The MAC – RTM project will contribute to enhance the competitiveness of the European SMEs in the global market with the development of an integrated system that is technically innovative, environmentally friendly, and economically viable.The developments in the MAC-RTM project will allow the adaptation of the RTM and RTM-light processes for medium volume components production with the following advantages:• Reducing the production cycle time in 40%, hence an increase in the productivity and costs efficiency• Decreasing energy consumption in 70%• Lower styrene emissions (90 % reduction compared to open mould processes)• Increase the crosslink (polymerization level) to nearly 100%• Cheap polymeric moulds, which will reduce the mould cost by 30%• Material saving as the pieces will not need to be over-dimensioned due to the 100% crosslinkA general purpose part will be designed, manufactured and tested, whose characteristics will incorporate features of standard moulds used in different industrial sectors in order to demonstrate that the proposed technology allows the fabrication of composite parts with better properties than parts obtained using conventional RTM and RTM-light process
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Integrable Many-Body Systems through the Mathematical Lens'.

assistant: **Objectives**

The project focuses on the relation between integrable many-body systems and three important fields of  mathematics:  partial  differential  equations,  Painlev  equations,  and  probability  theory.   The  goal is to build new connections in this context by considering recent results as follows. The first objective consists in explaining how a class of integrable many-body systems that appeared over the last 5 years can be used to parametrise specific solutions to hierarchies of partial differential equations. An algebraic and a geometric interpretation of these parametrisations will be sought. The second objective deals  with  the  extension  of  the  Hamiltonian  formulation  of  many-particle  Painlev  equations,  called the  Calogero-Painlev  correspondence,  to  new  cases.   This  investigation  will  make  a  central  use  of the current activity on discrete Painlev equations and the quantum analogues of Painlev equations. The  third objective  related to  probability  theory is  two-fold. On  the one  hand,  quantum versions of integrable many-body systems will be derived by adding noise to specific diffusion processes that are constructed using their classical versions. On the other hand, important properties of probability distributions appearing in random matrix theory or the study of beta ensembles will be obtained. The point of view will be to interpret these distributions in terms of suitable many-body systems whose integrability will play a key role for the computation of the desired properties.


**Keywords:** Integrable systems,  Many-body systems,  Integrable probability,  Painlevé equations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Targeting the tumour microenvironment to improve pancreatic cancer prognosis' in the context of a Seventh Framework call.

assistant: **Objectives**

Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased risk for pancreatic cancer indicate, that the tumour microenvironment is of particular importance for carcinogenesis in the pancreas. The long-term objective of this proposal is to increase survival of pancreatic cancer patients by exploring the contribution of the tumour microenvironment to the failure of presently available oncological treatments. For this purpose the clinical observation will be reverse-translated into innovative in-vitro and mouse models closely mimicking the human disease. This will allow a profound study of the mechanistic basis of treatment failure by deciphering the complex network between components of the microenvironment and cancer cells leading to increased resistance to chemotherapy and infiltrative growth along adjacent lymphatic and neural structures as well as metastatic spread. Identification of cancer (stem) cell-autonomous as well as stromal-derived mediators of invasion and chemoresistance will lead to novel drug targets to overcome the current therapeutic dilemma. The consortium has been specifically designed to include all required levels of expertise: 1) surgical and medical oncology groups conducting the largest clinical trials for pancreatic cancer in Europe, 2) expert pancreatic pathologists, 3) basic scientists focused on the study of carcinogenesis and tumour microenvironment interactions in the pancreas, 4) molecular oncology groups
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nonlinear-Distortion Free Communication over the Optical Fibre Channel' (FRECOM) targeting Horizon 2020.

assistant: **Abstract**

MotivationThe enormous growth in the Internet of Things and server farms for cloud services has increased the strain on the optical communication infrastructure. By 2025, our society will require data rates that are physically impossible to implement using current state-of-the-art optical communication technologies. This is because fibre-optic communication systems are rapidly approaching their fundamental capacity limits imposed by the Kerr nonlinearity of the fibre. Nonlinear distortion limits the ability to transport and detect the information stream. This is a very critical problem for increasing the data rates of any optical fibre communication system. Proposed research The only physical quantities not affected by the nonlinearity are eigenvalues, associated with the optical fibre propagation equation. Eigenvalues are thereby ideal candidates for information transport. The concept of eigenvalues is derived under the assumption that the fibre is lossless and that there is no noise in the system which is not strictly correct. Therefore, novel methodologies and concepts for the design of a noise mitigating receiver and a noise robust transmitter are needed to reap the full benefits of optical communication systems employing eigenvalues. This proposal will develop such strategies. This will be achieved by combining, for the first time, the fields of nonlinear optics, optical communication and nonlinear digital signal processing. The results from the project will be verified experimentally, and will form the basis for a new generation of commercial optical communication systems.Preliminary resultsOur proof-of-concept results demonstrate, for the first time, that noise can be handled by employing novel receiver concepts. An order of magnitude improvement compared to the