RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biological auto-detection and termination of heart rhythm disturbances' (Bio-ICD).

assistant: **Innovation**

Imagine a heart that could no longer suffer from life-threatening rhythm disturbances, and not because of pills or traumatizing electroshocks from an Implantable Cardioverter Defibrillator (ICD) device. Instead, this heart has become able to rapidly detect & terminate these malignant arrhythmias fully on its own, after gene transfer. In order to explore this novel concept of biological auto-detection & termination of arrhythmias, I will investigate how forced expression of particular engineered proteins could i) allow cardiac tissue to become a detector of arrhythmias through rapid sensing of acute physiological changes upon their initiation. And how after detection, ii) this cardiac tissue (now as effector), could terminate the arrhythmia by generating a painless electroshock through these proteins.To this purpose, I will first explore the requirements for such detection & termination by studying arrhythmia initiation and termination in rat models of atrial & ventricular arrhythmias using optical probes and light-gated ion channels. These insights will guide computer-based screening of proteins to identify those properties allowing effective arrhythmia detection & termination. These data will be used for rational engineering of the proteins with the desired properties, followed by their forced expression in cardiac cells and slices to assess anti-arrhythmic potential & safety. Promising proteins will be expressed in whole hearts to study their anti-arrhythmic effects and mechanisms, after which the most effective ones will be studied in awake rats.This unexplored concept of self-resetting an acutely disturbed physiological state by establishing a biological detector-effector system may yield unique insight into arrhythmia management. Hence, this could provide distincti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Promoting Scientific Creativity by Utilising Web-based Research Objects' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Scientific creativity and innovation represent the beating heart of European growth at a time of rapid technological change. Dr Inventor is built on the vision that technologies have great potential to supplement human ingenuity in science by overcoming the limitations that people suffer in pursuing scientific discovery. It presents an original system that will provide inspiration for scientific creativity by utilising the rich presence of web-based research resources. Dr Inventor will act as a personal research assistant, utilising machine-empowered search and computation to bring researchers extended perspectives for scientific innovation by informing them of a broad spectrum of relevant research concepts and approaches, by assessing the novelty of research ideas, and by offering suggestions of new concepts and workflows with unexpected features for new scientific discovery.<br/>Dr Inventor is an attempt to understand the potential of technology in the scientific creative process within current technology limitations. It represents a sound balance between scientific insight into individual scientific creative processes and technical implementation using innovative technologies in information extraction, document summarization, semantics and visual analytics. The outcomes will be integrated into a web-based system that will allow evaluation in a selected research area under real-world settings with carefully designed metrics, benchmarks and baseline for creative performance, leading to tangible measurements on the performance of the technologies in enhancing human creativity and a blueprint for future technologies in computational creativity.<br/>Dr Inventor has huge implications for scientific innovation in Europe, as it has the potential to change the way in which sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'End-to-end quality of service support over heterogeneous networks' to be submitted under Sixth Framework.

assistant: **Abstract**

Quality of Service (QoS) is a key requirement which represents a significant infrastructure upgrade for forthcoming networks. EuQoS will deliver a Flexible and Secure QoS Assurance System (EuQoS system). As QoS is an access challenge the EuQoS system will be integrated, tested, simulated, validated and trialed in NREN and operator research access networks with the GEANT core providing Pan European support.This and similar heterogeneous infrastructure requires a QoS technical solution that has not been synthesised to date EuQoS will transform QoS state-of-the art into a solution ready for infrastructure upgrade and real-life deployment by bringing together an impressive critical mass of researchers and companies and users from all over Europe. The key objective of the EuQoS project is: To research, develop, integrate, test, validate and demonstrate end-to-end QoS technologies to support advanced QoS aware applications - voice, video-conferencing, video-streaming, tele-engineering and medical applications - over multiple, heterogeneous research, scientific industrial and national research network infrastructure testbeds for real life users.The EuQoS system will add value to existing applications through trials which will include medical, aerospace, SME, corporate, family and education users EuQoS has two phases:- Phase 1 will complete Version 1.0 of the EuQoS System to support of Pan-European trials with VoIP, on xDSL, UMTS LAN and WiFi; VoD on UMTS, LAN and WiFi, Video Conference(p2p) on xDSL, UMTS and Lan; Medical Applications on LAN and WiFi in month 18.- Phase 2 will complete Version 2.0 of the EuQoS System to support of Pan-European trials Video Streaming (mp) on xDSL, UMTS, Lan WiFi, GMPLS and Satellite; Tele-engineering (mp) on LAN and WiFi; Medical Applications on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Science shop for innovative mobility solutions for mobility challenged Europeans' to be submitted under Sixth Framework.

assistant: **Abstract**

The overall aim of this project is to accommodate through a University based Science Shop (called InMoSion) to develop all necessary expertise and know-how for assisting communities with the deployment of an innovative transportation system to meet the mobility needs of elder and mobility challenged Europeans. The system will be a flexible, technologically advanced demand based paratransit system. The InMoSion project will be lead by the University of Thessaly in Volos, Greece and will support at first a Greek Capodistrian Municipality, the Municipality of Philippi, to deploy a paratransit system in order to enhance the mobility in the area. After that, the InMoSion project will help communities across Europe and elsewhere that want to investigate the potential deployment of such a demand based paratransit system.The Science Shop will develop all necessary know how through this initiative and will create a core group of students and researchers that can support free of charge communities through the whole process: from conception, feasibility analysis, needs analysis, requirements analysis, system design, yield management, deployment, evaluation and maintenance. It is a well known fact that Europeans are rapidly aging, mainly due to the low birth-rate and the increase in people's lifespan; new technologically advanced and flexible transportation solutions must be developed in order to address their constantly growing mobility challenges. Older people are usually unable to drive but prefer to live in low-density suburban locations.The transportation systems in these areas are often quite inadequate, which creates serious mobility problems, especially for elderly and disabled people. Note here that while the elderly and disabled are the target customers for the proposed S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Molecular bases of the ton mutations in arabidopsis thaliana'.

assistant: **Objectives**

Research objectives and content In the host laboratory a series of Arabidopsis mutants have been isolated which have profound defects in early development. The ton mutants are dwarf and have surernumary cell layers. Cells have an aberrant shape and are unable to elongate, whatever stimuli applied. However, the general organisation is conserved, all organs and cell types being present. These mutants are altered in cytoskeleton, and the preprophase band is never observed, which apparently leads to a complete disorganization of division planes. Why are these mutants, which are strongly altered in cell division and cell elongation, still capable of partial organogenesis? In order to answer this question, the cloning of the ton1 and ton2 loci has been undertaken. The ton2 gene is currently being cloned by a positional cloning approach. The ton I locus have been isolated from a T-DNA tagged allele. The mutation affects two genes in tandem, very similar to one another. These genes encode small acidic proteins, which do not show striking similarity to proteins of known function. The work proposed here aims at elucidating the biochemical function of the ton1 proteins. The strategy involves the localization of the protein by immune-cytology using confocal microscopy; promoter fusions to the green fluorescent protein to localise transcription. Partner proteins will be isolated by the two-hybrid yeast cloning system. The final steps of positional cloning of the gene will also be undertaken by the applicant. Training content (objective, benefit and expected impact) In the Versailles laboratory of the l.N.R.A the applicant will have the opportunity to learn most of the up to date gene analysis techniques and concepts in the field of plant developmental biology and to acquire experien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'How does the X chromosome regulate DNA methylation in pluripotent stem cells?' (XXDNAM), addressing dissemination and exploitation.

assistant: **Impact**

Epigenetic processes regulate gene transcription states during cellular differentiation, playing key roles in the maintenance of pluripotency and differentiation. Epigenetic alterations are common in diseases such as in cancer and cognitive disorders. Understanding the mechanisms by which epigenetic states are inherited and propagated is of fundamental importance, and will help in the development of biomarkers for screening as well identification of targets for disease treatment.DNA methylation remains the best-characterized epigenetic process. XX pluripotent stem cells (Embryonic Stem (ES) and induced Pluripotent Stem (iPS) cells) display genome-wide hypomethylation relative to XY stem cells but the mechanisms are unknown. This proposal will elucidate the pathways responsible. Irradiation Microcell-Mediated Chromosome Transfer (XMMCT) will be used to identify the critical region(s) of the X chromosome involved. In parallel and as an alternative approach, candidate X-linked genes will be over-expressed in XY ES cells to identify the factors responsible for global hypomethylation. Further insight will be provided using protein interaction screens using epitope-tagged versions of all active Dnmts as well as the known regulators URHF1 and Dnmt3L in XX and XY ES cells. The role of XX-induced hypomethylation in cellular reprogramming will be investigated by using different cell types from Oct4-GFP transgenic mice to examine whether iPS efficiency is affected by cells with a greater propensity to lose DNA methylation. Together these aims will elucidate the signals necessary to maintain global genomic DNA methylation. Aberrant loss is an important hallmark and contributor of disease that could be used for disease diagnosis and treatment. It could also be exploited to help impr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chatting with Neurons: A novel approach to the study of neurophysiologic responses of neuronal tissue in vitro, combining nanotechnology, tissue engineering, microfluidics and neuroelectrophysiology' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Laboratory-on-a-Chip technology was introduced in this field. To avoid the complexity of an animal model and to reduce the number of animals for pre-clinical research cell culture models are important. Here, the combination of microfluidics, tissue engineering and neuroelectrophysiology on MEA-chips is suggested. Because neuronal tissue on chip may act differently from the neurons in their natural environment, the first objective is to follow a systems engineering approach to realize a platform technology, which allows us to reliably co-culture cells in a 3D interconnected configuration, providing an artificially vascularized system on a MEA. For on-line monitoring of the culturing conditions, we will implement micro-total analysis systems (TAS) technology proposing microchip capillary electrophoresis, potentially coupled to mass spectrometry, to correlate electrophysiology with neurochemistry. Previously, it has been demonstrated that physical and chemical micro- and nanostructures influence cell guidance, viability and cell differentiation, so far, unfortunately without a unifying theory to explain the involved mechanisms. Therefore, our second objective is to further our understanding with respect to the influence of nanocues, implementing microfluidic programming to activate porous nanostructures on MEA and investigate cellular signaling and pathway reactions related to the cell’s adhesion mechanism. Combining the first and the second objective will allow us to work towards clinical questions of neurodynamic diseases as epilepsy, characterized by intermittent abnormal synchronization of different neuronal populations. We hypothesize that for these disorders, 3D cell co-culture models will resemble the natural neural networks more closely than 2D, which may subsequen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'RAILway Ground truth and digital mAP'.

assistant: **Objectives**

RAILGARAILGAP is an essential step towards green, safe, smart mobility on rails. It focuses on developing innovative High Accuracy, High Precision Ground Truth and Digital Maps, essential elements of an EGNSS train positioning system and a V&V Environment.  The outcomes will address two show stoppers: lack of high-quality data with ground truth (needed for developing new navigation systems) and a modernized process for mapping existing train tracks cost-effectively, by deriving mapping information directly from trains in commercial operation.  This will enable positioning with unprecedented reliability and efficiency in the railway operations. The missing piece is a methodology to collect and aggregate the data without operational overheads or labour, at minimal cost in hardware while removing any need for trackside infrastructure. RAILGAP addresses these challenges with a method based on commercial trains collecting massive amounts of data. This enables characterizing even the most challenging railway environments. Results will support the GSA roadmap in adopting EGNSS in train Command & Control Systems (CCS) and trigger contributions from stakeholders. We will exploit a fusion of GNSS with data from other sensors as IMU, Lidar and Camera. Dual-Freq., Multi-Const. GNSS is key to improving map accuracy in challenging environments (urban areas, tree canopies) extending coverage of GNSS on rails. RAILGAP will make ERTMS and CCS with EGNSS sustainable, helping modernise regional and local lines, where passengers will benefit daily. It also enhances the case for ERTMS and CCS by lowering energy consumption. Project coordinator is RFI, who has been very involved in piloting GNSS-based technology for ERTMS like the Novara-Rho pilot line. The team has experts in rail and satel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Basic Sciences 4 Society needs: postdoctoral training' under Horizon Europe.

assistant: **Concept**

“Basic Sciences 4 Society needs: postdoctoral training” (BS4S) is a research training programme of the Institute of Physical Chemistry of the Polish Academy of Sciences (IChF) for postdoctoral fellows (ERs). Focused on fundamental research, IChF is also known for its commercialisation endeavours, such as spinning off Scope Fluidics, which later sold digital PCR to Bio-Rad Labs for $170 m. The programme aims to reshape researchers’ mindsets, encouraging them to consider societal, market, or technological needs in their work. BS4S promotes a need-driven innovation approach, making research more accountable to society and enhancing knowledge flow between academia and business. BS4S will admit 20 fellows (36M fellowships) selected in transparent, open and merit-based calls, evaluated by external independent experts. Candidates can choose the research area from IChF’s offer (chemistry, biology, physics) and propose their own interdisciplinary project. Mentors’ expertise aligns with IChF’s Core areas Of Excellence (Advanced Biomaterials & Technologies for Health; Photonics and Light-Driven Processes; Catalysis & Materials for Sustainable Transformations) and with Horizon Europe, Green Deal and Smart Specialisations Strategies.BS4S fellows will have two mentors: one from IChF and one from a foreign institution. 20 ERC/EIC application-oriented holders have committed as partners to mentor fellows and host secondments. During the fellowship, ERs will advance their projects through CDP-driven training, focusing on transforming fundamental research into products/services, with support from 12 businesses offering internships and mentorship. Partners like Scope Fluidics (microfluidics for medicine), Perosol (perovskite solar cells) or EcoResorces (sustainable solutions) will drive su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MEthane activation via integrated MEmbrane REactors' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The key objective of the MEMERE project is the design, scale-up and validation of a novel membrane reactor for the direct conversion of methane into C2H4 with integrated air separation. The focus of the project will be on the air separation through novel MIEC membranes integrated within a reactor operated at high temperature for OCM allowing integration of different process steps in a single multifunctional unit and achieving much higher yields compared with conventional reactor .To achieve this MEMERE aims at developing novel, cheap yet more resistant oxygen selective membranes (target costs < 5000€/m2) for efficient air separation and distributive oxygen feeding to the reactor. The objective is to give a robust proof of concept and validation of the technology (TRL 5) of the new technology by designing, building, operating and validating a prototype module based on the OCM technology that will be integrated in a mini-plant built in containers. MEMERE technology will deliver direct conversion of methane to C2+ with a reduced energy penalty in a much effective way (target C2 yields >30%) as compared to currently available techniques contributing to the implementation of the Roadmap and Implementation Plan for process intensification of the SET-Plan. Additionally, as air integration is integrated in an efficient way in the reactor, the MEMERE technology can be used a small scales to convert methane produced in remote areas where conventional technologies cannot be exploited.