RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Manufacturing of Scaffolds from Novel Coated Microspheres via Additive Manufacturing Techniques for Temporomandibular Joint Tissue Engineering' (SPHERESCAFF), addressing dissemination and exploitation.

assistant: **Impact**

The project goal is to manufacture scaffolds for tissue engineering from novel coated microspheres. Such scaffolds have a high potential to be used in bone and cartilage regeneration in orthopaedic or temporomandibular joint (TMJ) applications. Monodisperse microspheres that allow encapsulation of growth factors have been developed at the University of Kansas (KU). Prof. Detamore from KU and I worked on using selective laser sintering (SLS) to sinter microspheres that have a coating to satisfy biological and mechanical needs of a scaffold with a composite material. SLS and other additive manufacturing (AM) techniques allow to create three dimensional structures with internal architectures, which is not possible by the process currently used to make scaffolds from the microspheres. We were successful with large microspheres in initial trials and need to bring down the microsphere size for the proposed use in tissue engineering for the TMJ, especiallyfor use with the animal models for early stage (rabbit) and pre-clinical studies (pig) beyond my project scope. The challenge is to apply even coatings with a predefined thickness on microspheres with a diameter of 50-200 μm in a circulating fluidised bed. In addition, we want to establish a non-thermal AM technique for the use with microspheres by adaption of 3D printing techniques to allow inclusion of growth factors. The research is complemented by cell culturing to investigate the performance of the scaffolds generated via the AM techniques.Bringing the microsphere technology and the associated TMJ research to Europe and joining it with my expertise in AM enables me to set up an independent research group that can gain high visibility in the international TMJ research community. The project includes training on the circul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart-Taylored L-category Electric Vehicle demonstration in hEtherogeneous urbanuse-cases' (STEVE), addressing dissemination and exploitation.

assistant: **Impact**

Movement is at the heart of any city. Urban mobility faces significant challenges from two global megatrends: growing urbanisation and ageing population. Light electric vehicles (EL-Vs) could represent a viable solution to traffic congestion and pollution in cities. However, their successful integration into the urban transport system requires a clear understanding of the individual consumer needs.By involving human science and transportation specialists, the STEVE partners have developed a framework to interpret these forces. Focus will be on mature cities of medium size (Torino: 800.000 inhabitants, Villach 60.000, Calvià 60.000, Venaria 35.000), where STEVE will generate data to support the design of next generation EL Vs, and provoke the mind-shift necessary for swift market penetration of them.The primary idea of STEVE is to implement and test a human-centric approach to electro-Mobility-as-a-Service (eMaaS), according to the “Move2Me” vision of the consortium. This will provide low-cost and financially sustainable EL V solutions and “gamified” services, to enhance users’ awareness, engagement and vehicle energy efficiency.A core item of STEVE is a low-cost electric quadricycle developed by a worldwide OEM in Turin, with start-of-production expected in 2018 at a market price of €8000. The quadricycle will integrate high-technology contents with respect to the current competitors, and will be pilot-tested, together with many other EL-Vs, during extensive demonstration phases in the four STEVE citiesSTEVE will guarantee a strong impact in terms of business development and jobs, and enhance the European competitiveness in the eMaaS sector while also leveraging Manufacturing.The consortium will also give a primary role to SMEs: while large enterprises will provide the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Intelligent Nano-encapsuled siRNA for Restoring Immune Cell Response to Cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

WHY: To effectively bring siRNA-based therapeutic for cancer immunotherapy into the hands of clinicians requires the development of fundamentally new mechanisms to overcome current drawbacks. Accomplishing this will enable more efficient treatment with less side effects. WHAT: RE-IMMUNE is an interdisciplinary programme in which the field of nanomaterial and nucleic acid nanotechnology merge to develop intelligent nano- encapsulated siRNA for safe and efficient delivery of siRNA in cancer-associated immune cells, to re-program and shift the tumor microenvironment from pro to anti-tumoral. To achieve this goal, I will undertake a high risk/high gain programme at the forefront of nanomedicine. The leading idea is to overcome the drawbacks of naked siRNA by combining two synergic strategies that will protect siRNA until recognition of its target site. I will evaluate intracellular trafficking of siRNA nanodevices and the silencing effect. I will also investigate possible synergic effect of a siRNA cocktail able to target different genes at the same time. Finally, I will evaluate the re-immunoediting action in vivo. HOW: The challenge met by the proposed program is to provide a groundbreaking contribution to cancer treatment. To achieve these objectives, I will combine the different scientific backgrounds and expertise of two leading scientists. Prof. Frank Caruso (University of Melbourne) is a world-wide recognized expert on nanomaterials and biomedicine, and Prof. Francesco Ricci (University of Rome Tor Vergata) leads a young and dynamic group at the forefront of DNA nanotechnology for sensing and drug-delivery applications. The fellowship will proceed through a well-defined set of research and training tasks. Thanks to this MSC Fellowship, I will diversify my scientific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Wavelet analysis of high-resolution eulerian and lagragian turbulence data and intermittency'.

assistant: **Innovation**

Research objectives and content This proposal develops and improves new wavelet methods initiated in DAMTP. These methods enable new refined characterisations of intermittency and of small-scale geometry of 1-dimension signals. They link the global intermittency to the local geometry of the flow structures. These methods will be developed in order to provide accurate systematic tools of data investigation and a systematic description of intermittency. These methods will also be extended to capture the local flow structures in 2-dimensional and 3-dimensional turbulence-data sets. These wavelet methods will be used on wide a range of well-resolved data obtained from Direct Numerical Simulations and laboratory experiments. The intermittency of the turbulence in the dissipation range will be investigated. We will systematically study the dependence on the Reynolds number and attempt to define the significance of the Taylor and Kolmogorov microscales. We will also describe the local topology of dissipation range structures. The methods will be improved in order to investigate the differences and similarities between Eulerian and Lagrangian intermittency. Training content (objective, benefit and expected impact) As an important part of this proposal F. Nicolleau will be trained to wavelet methods and Lagrangian approaches which will complement his initial training on fractal and Eulerian approaches to turbulence. These wavelet approaches are rather unknown to the Laboratory of F Nicolleau in Lyon and will have a significant impact on the closure and combustion approaches developed in Lyon.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Free Respiratory Evaluation and Smoke-exposure reductionby primary Health cAre Integrated gRoups' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

FRESH AIR is a 3 year project which addresses the urgent need to prevent, diagnose and treat lung diseases in LMICs and other low-resource settings where the greatest burden of disease is experienced. Our Consortium brings together leading international respiratory researchers, clinicians and policy experts from EU member states and the US who have expertise and experience of the challenges of implementation in LMICs and healthcare providers, policy makers and implementers from four countries that represent very different low-resource settings.  Members will work together to adapt and test innovation and evidence-based practice in the prevention, diagnosis and treatment of lung disease in four low-resource settings in Uganda, Kyrgyz Republic, Vietnam and Greece with high levels of tobacco consumption and exposure to Household Air Pollution (HAP). In so doing, the Consortium will transfer skills and technology from EU member states and the US to new contexts and explore a range of implementation science research questions. The new knowledge this generates will be widely disseminated nationally, regionally and internationally, ensuring the scale-up of interventions tested by the project and global impact of research findings.  The project will also provide new perspectives on policy issues of concern to EU members, increase the international profile of EU funded research on key health challenges and open up markets for healthcare innovations. The project has 7 specific objectives focused on the following:1. Identifying factors influencing the implementation of evidenced-based interventions2. Exploring which awareness-raising approaches are most effective in achieving behaviour change3. Adapting interventions that provide smoking cessation support4. Testing innovative diag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Research empowerment on solute carriers (ReSOLUTE)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Research empowerment on solute carriers (ReSOLUTE) proposal aims at inducing a decisive acceleration in theintensity of SLC research worldwide while establishing solute carriers (SLCs) as a tractable target class. It is composed of acore consortium of seven academic/SME members (CeMM, Univ. of Oxford, Univ. of Manchester, AXXAM Spa, Univ. Leiden, Max-Planck Institut für medizinische Forschung, Univ. Wien) and six industrial partners (Pfizer Limited UK, Novartis Pharma AG, Boehringer-Ingelheim, Vifor Pharma Group, Sanofi Aventis Recherche et Développement, Bayer AG) with established and complementary expertise combining industry grade standards and systems level principle-driven analysis.ReSOLUTE merges systematic and focused approaches: 1) the generation of reliable and validated ‘hardware’ such as cell lines, proteins, antibodies/high affinity binders and large ‘omics’ datasets, 2) a central deorphanisation process coupling genomic engineering to metabolomics and supported by genetic and proteomics studies, 3) a non-redundant process to test systematically the suitability of a certain SLC to a variety of assay formats, 4) a collection of interlinked networks that cover different expertise, datasets and functional connections among SLCs, integrated into large-scale data repositories and a dedicated knowledgebase. The ReSOLUTE strategy will be applied in parallel at the super-family level and, in a more in-depth manner, to a prioritized gene list elected to be potential drug targets. To implement this and achieve the expected goals, the consortium is supported by a large network of academic and industrial partners with specific knowledge of certain SLCs and tools, willing to be accessed at any time and provide specific expertise. Together with a strong dissemination
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PROgramming Gauge-invariant Rydberg AtoM arrays' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Many strongly-correlated phenomena in condensed-matter and high-energy physics, from high-Tc superconductivity to quark confinement, can be described by lattice gauge theories (LGT), field theories invariant under local transformations. The immense computational complexity associated with solving LGT using classical computers hinders progress in these fields, where many questions remain open. Although quantum computers can address these questions more efficiently than classical devices, current quantum hardware is limited in the absence of error correction, complicating the reach of a practical quantum advantage in the near term.Co-designing both quantum hardware and software tailored to simulate LGT, addressing non-trivial regimes while minimizing experimental resources, is therefore a challenging but timely task. Rydberg atoms in tweezer arrays, which have recently emerged as a powerful quantum simulation platform, offer unique capabilities that can be harnessed in this direction. On the one hand, the strong Rydberg interaction and the associated blockade mechanism naturally leads to emergent local symmetries. On the other hand, the possibility of controlling many internal atomic states as well as using fermionic atoms allows to locally encode and simulate non-abelian gauge fields and fermionic matter fields, respectively, minimizing resource overheads.PROGRAM will investigate this hardware-efficient approach and develop quantum simulation protocols for LGT using Rydberg atom arrays, focusing on three main challenges: (i) simulating non-equilibrium LGT dynamics in 2D, and (ii) implementing non-abelian gauge symmetries, as well as (iii) fermionic matter fields, in a scalable manner. The Researcher will design these protocols using both analog, digital and variational n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Healthcare Performance Intelligence Professionals', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Balancing between improving population health, delivering quality care for individuals, and containing costs is a timely social/economical challenge in Europe. There is great potential achieving this through healthcare (HC) system performance intelligence optimizing effective use of available HC data in countries. Effective implementation of HC performance intelligence (HPI) by skilled professionals will improve integrated service delivery; patient engagement; equality in access to HC; health outcomes; and reduce waste in HC. Translating HC data into meaningful, valid, actionable performance intelligence that is transferrable into actions to improve HC systems requires multidisciplinary skills & innovative competencies; currently not well developed in training programmes and the scientific community and missing in today’s European HC market. The ETN for HPI Professionals (HealthPros) fills this gap and directly impacts the European Research Area by training innovative “Healthcare Performance Intelligence Professionals” uniting a multidisciplinary consortium tackling private, public, academic sectors.13 ESRs will be trained in multidisciplinary innovative scientific technical and complementary skills, seconded to private / public / academic HC sectors in multiple countries and build relations with potential future employers. 5 ESRs work on PhD projects related to HC performance measurement optimizing the use of available registry and administrative data and applying statistical models to provide actionable input to HC performance management. 4 ESRs work on PhDs to translate performance intelligence into value-creating HC governance mechanisms; 4 ESRs work on PhDs aimed to impact the actual use of performance intelligence by different end-users. ESRs will have unique HC d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Adaptive radiation therapy using multi-modal imaging and segmentation'.

assistant: **Objectives**

This multidisciplinary project involves computer engineering, physics and life sciences. Cancer is the second leading cause of death in the industrialized countries and about 60% of the patients are treated with external beam radiotherapy (RT). Today, RT planning is based on a single computed tomography (CT) data set acquired at the onset of treatment. However, the position and shape of healthy organs, and the morphology and biology of the tumour vary significantly during the weeks of treatment, and tumour definition based on CT has limited accuracy.These uncertainties are taken into account via generic 'safety' margins around the tumour, which are often too large. Integrating multi-modality images such as CT, MRI and PET acquired several times during treatment and adapting the treatment accordingly will increase the dose to the target and limit the dose to nearby healthy organs. The main bottleneck in multi-modal RT is the substantial increase in data and workload. Organ and target contouring, an essential step in RT, is carried out manually on the computer on each image slice and takes hours per data set.The project will develop novel automated image segmentation and fusion technology to enable efficient and consistent treatment, and the fellow will get training on the clinical aspects involved. Adaptive RT will improve life for the aging population, with the potential to save a few thousand lives per year. The outgoing host Princess Margaret Hospital, Toronto, Canada, is the leading clinical research centre f or adaptive multi-modal RT and has recently implemented the supporting infrastructure. The return host Philips Research, Hamburg, is one of the leading research groups for image acquisition and processing technology. The researcher will strongly profit fro m the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identifying preclinical Alzheimer´s disease in the community using a panel of  biomarkers among individuals with Subjective Memory Complaints' (IPACBIS) under Horizon 2020.

assistant: **Objectives**

The dementia epidemic is a growing socio-economical problem in developed countries, including Europe, mainly due to aged population. Alzheimer´s disease (AD), the leading cause of dementia, has currently no prevention or cure. Identifying AD at early stages will likely improve the chances of developing an effective therapy. AD-related changes can be detected in brains of healthy individuals many years before the onset of cognitive decline using biomarkers. Testing all elderly healthy individuals would not be cost-effective, but interestingly many of them experience subjective memory complaints (SMC) but show preserved cognition when tested. Although conditions such as drugs, depression, anxiety or lack of sleep may be the underlying cause of SMC, a small percentage of individuals with SMC are experiencing the very initial symptoms of AD. The aim of this proposal is to identify which subgroup of individuals with SMC is at risk of developing AD dementia in the future. 200 individuals with SMC will be followed-up for 2y and tested with positron emission tomography with Florbetaben, plasma, lumbar puncture, optical coherence tomography and very sensitive neuropsychological tests at the Fundació ACE in Barcelona. Those finally classified as preclinical AD due to positive biomarkers at baseline and cognitive impairment at follow-up will be offered to join clinical trials for disease-modifying therapies against AD. The MSCA fellowship will allow the researcher to establish an independent career back in Europe after a stay in the United States, start academic tenure-track, improve her publication record, and receive specialized training in novel biomarker techniques and the preclinical phase of AD. The host organization will benefit from the researcher´s knowledge in tau imagin