RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structure-Function Analysis of the Chemokine Interactome for Therapeutic Targeting and Imaging in Atherosclerosis' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Atherosclerosis is characterized by chronic inflammation of the arterial wall. Mononuclear cell recruitment is driven by chemokines that can be deposited e.g. by activated platelets on inflamed endothelium. Chemokines require oligomerization and immobilization for efficient function, and recent evidence supports the notion that heterodimer formation between chemokines constitutes a new regulatory principle amplifying specific chemokine activities while suppressing others. Although crucial to inflammatory disease, this has been difficult to prove in vivo, primarily as chemokine heterodimers exist in equilibrium with their homodimer counterparts. We introduce the paradigm that heteromerization of chemokines provides the combinatorial diversity for functional plasticity and fine-tuning, coining this interactome. Given the relevance of chemokine heteromers in vivo, we aim to exploit this in an anti-inflammatory approach to selectively target vascular disease. In a multidisciplinary project, we plan to generate covalently-linked heterodimers to establish their biological significance. Obligate heterodimers of CC and CXC chemokines will be designed using computer-assisted modeling, chemically synthesized and cross-linked, structurally assessed using NMR spectroscopy and crystallography, and subjected to functional characterization in vitro and reconstitution in vivo. Conversely, we will develop cyclic beta-sheet-based peptides binding chemokines to specifically disrupt heteromers and we will generate mice with conditional deletion or knock-in of chemokine mutants with defects in heteromerization or proteoglycan binding to be analyzed in models of atherosclerosis. Peptides will be used for molecular imaging and chemokine heteromers will be quantified in cardiovascular patients
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Customer online behaviour analysis'.

assistant: **Innovation**

The objective is the development of a core European technological offering in the emerging sector of Customer On Line Behavioural Data Analysis. The need for high performance fraud detection applications based on this core technology has evolved, with different levels of maturity, in different markets. In the electronic money market dedicated software products have already appeared in the US. In the telecommunications market the needs have more recently been identified, and consequently there is significant market potential. In the international network services arena the commercial exploitation of the Internet is introducing new access monitoring challenges for service providers.The sectors identified above share some basic common features: in all of them there is a very large customer base accessing a digital network based service and generating very high transaction volumes. In each of these sectors fraudulent/criminal behaviour is increasingly experienced, and is expected to continue its growth at the exponential rate of the Internet expansion. Only a combination of HPCN technologies and advanced pattern recognition techniques can provide a suitable solution to the need of monitoring these transactions and detecting fraudulent behaviours in an on-line environment. The focus is on the requirements of the credit card market, where a significant market for on-line fraud detection is mature. The validity of the approach in the telecommunication sector will be assessed through a set of focused experiments. A neural based fraud detection software prototype will be developed and a performance characterisation activity, on SMP architectures, will be executed with specific reference to credit card fraud detection requirements. In addition, experimental activities on telecomm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress' (URBANEPIGENETICS).

assistant: **Innovation**

The impact of urbanisation on wildlife is of increasing global concern. It is well known that exposure to urban environmental stressors increases oxidative stress. More recently, exposure to pollutants has been shown to directly modify the epigenome, via DNA methylation, in humans. Oxidative stress may be a key mechanism mediating epigenetic modifications in response to pollutant exposure and thereby influencing development, disease resistance and ageing. This multidisciplinary project outlines the first study to date of the epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress. Early-life stress exposure can have profound effects on phenotypic development and long-term fitness. Epigenetic mechanisms are influenced by environmental cues during development and therefore may mechanistically link developmental conditions with later-life performance. Using urban and rural populations of birds, we will perform experimental studies in the field and lab to examine whether increased oxidative stress during development modifies patterns of global and gene-specific DNA methylation and thereby alters genome stability (via DNA damage and telomere attrition) and expression of antioxidant genes. To achieve this, we propose a new framework to explain how the modification of DNA methylation and telomere length may be linked and decoupled by the direct and indirect effects of oxidative stress at different stages during development. Pilot data support this framework. This will enable us to disentangle the mechanistic relationships between exposure to urban stressors, oxidative stress, DNA methylation and telomere dynamics during development and the consequences for growth and survival in an altricial bird species. The project has implications for mul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Categorical, Homological, and Non-commutative methods in Geometry'.

assistant: **Concept**

This proposal is primarily interested in algebraic geometry, a field that underpins geometric intuition with the precision brought about by calculation from algebra. The algebraic information of an algebraic variety - the set of common zeros of polynomial equations – is packaged in sheaves and organized in categories, which makes it possible to study these objects by importing the tools of homological and (non-)commutative algebra. This categorical approach is natural for many of the current leading questions in mirror symmetry, birational geometry, representation theory, and theoretical physics because it serves as a bridge between the geometric and algebraic language.  It is also fundamental, as many properties and even classification results are not possible without it.  The proposal is deeply interdisciplinary, and it connects broad areas of algebra and geometry. It naturally splits into three parts. The first aims to investigate one of the most fundamental properties of curves, namely contractibility, with non-commutative deformation theory. It will generalize classical results using modern language, at the same time producing many new explicit examples of rational curves in threefolds. Linking contractibility and non-commutative algebra will bring deep consequences for the birational and enumerative geometry of Calabi-Yau varieties, advancing areas of string theory.The second part studies surfaces with mild positive curvature (Fano, but with ineffective anticanonical bundle). The main objective is to prove a mirror theorem, packaging physical information with tools of homological algebra. The new heuristics, definitions, and techniques will open up an avenue to investigate higher dimensional settings.The third part involves reconstructing varieties from associated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'The application of time-domain, inverse-scattering methods to the reconstruction of the vocal tract potential function'.

assistant: **Innovation**

The main goal of this proposal is the development and application of time-domain, inverse-scattering methods to the reconstruction of unknown potential functions in the one-dimensional acoustical Klein-Gordon equation. This equation is used to model the mechanism of speech. It has been recently shown that the acoustical Klein-Gordon equation precisely determines the natural resonance frequencies (formants) of the human vocal tract.The novelty of this model is that the sound is specified by a unique configuration of barriers and wells along the tract, by analogy with quantum-mechanical wave-scattering problems. This is in contrast to conventional models based on the Webster horn equation and the vocal tract area function, where the same sound can be produced u sing many different vocal tract area functions and little progress has been made over many years.In consequence, this new result opens up the possibility of identification of sounds on the basis of the shape of the vocal-tract potential alone. We intend to develop techniques for the reconstruction of this potential from real human speech. In the preliminary part of the research we will examine different numerical techniques for solving the forward problem - the sound production. We then intend to develop the method of the vocal tract potential inversion from the output pressure-wave data, based on methods developed in reflection seismology.In the last part of the project we intend to apply these techniques to real human vowels. The proposed research has the potential to lead to better speech recognition devices then existing ones which currently do not take vocal tract physics into account and cannot adapt to natural human speech styles, such as ordinary conversation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Redefining Drone Safety and Autonomous Operation for Indoor Commercial Applications' under Horizon 2020.

assistant: **Concept**

Commercial drones - technically known as Unmanned Aerial Vehicles (UAVs) – are one of the fastest-growing markets (200,000 units sold for commercial use last year).  Increased safety, precise data collection, improved productivity, higher scalability and reduced operational costs make them suitable for a wide range of commercial applications mainly in infrastructure, media and entertainment (M&E), agriculture and telecommunications. However, their rapid adoption in indoor applications is restrained by limitations of Multi-rotors (the main commercialized technology) in operational safety, autonomous operation and flight range.Part quadcopter - part blimp, Skye aims to revolutionize the commercial drone’s market by introducing the first UAV that solves the two most critical challenges of indoor flying drones: collision/injury risks and fully autonomous operation. Based on our patent pending “Redundant propulsion system”, we offer a drone powered solution able to fly completely safe above crowds (certified to fly above crowd in CH, USA and CN) and minimize any impact in case of system failure. All the above achieved by an easy to use system able to operate fully autonomously and carry a variety of payloads. By overcoming the limitations of multi-rotor technology we offer a superior drone technology with the following key competitive advantages: 1) High safety standards – collision tolerance (helium filled hull and redundant propulsion system), 2) Higher flight duration (smaller and more powerful air-impellers) and 3) Fully autonomous 24/7 operation (proprietary indoor GPS solution).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural multiscale modelling of extrusion-based 3D and 4D printed materials' (2014-2020).

assistant: **Innovation**

Fused Deposition Modelling (FDM) is a common 3D printing technology based on the extrusion of thermoplastic filaments. While it was initially used only for prototyping, it is nowadays shifting towards manufacturing of mechanical components. 4D printing is a very novel technology to produce smart materials and structures through 3D printing of shape memory materials. Due to the specific process of FDM, the material obtains a characteristic mesostructure, which can be controlled through the print process. It is well known that mechanical properties like strength and toughness of the printed material significantly differ from those of the filament material and that they depend on the mesostructure. However, a real understanding of the material behaviour and the governing phenomena is still missing. The common modelling approach is to consider it as a composite laminate. In this proposal, I show that such models cannot capture the complex behaviour of FDM materials beyond the linear elastic regime. I argue that it can only be understood by considering nonlinear effects at the mesostructure, which needs to be interpreted as a 3D structure of bonded fibres rather than an anisotropic solid. Based on these observations, I will develop a new theoretical and computational framework, where representative volume elements of the mesostructure are modelled as an arrangement of beams with adhesive bonding and are linked to the macroscale through a multiscale approach. To make such computations feasible, it will be necessary to adopt modelling simplifications and a major challenge will be to find the right level of simplification that still can capture the relevant effects. It will also require fundamental development of novel high-order/low-cost numerical methods. The results of the s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Metallurgical patented Process Transforming Residues from the Electronic Industry into Valuable Precious Metals' (METALLICA) under Horizon 2020.

assistant: **Objectives**

Waste Electrical and Electronic Equipment (WEEE) is a complex mixture of materials and components that - because of their hazardous content, and if not properly managed (improperly treated and/or exported abroad) — can cause major environmental and health problems. Moreover, the production of modern electronics requires the use of scarce and expensive resources such as precios metals. In the meanwhile, Europe loses enormous amounts of said metals by waste incineration, landfilling or exporting of WEEE. In addition, WEEE is expected to reach 12 million tonnes a year by 2020. So to improve for the processing of WEEE with the aim to enhance resource efficiency the improvement of collection, treatment, and recycling of electronics at the end of their life as well as reduce the CO2 footprint (environmental/health impact) and contribute to a circular economy, our company, UrbanGold has developed the technology of METALLICA. The core of our technology consists of a novel specialised smelting furnace in combination with an optimised separation and refining process of innovative cooling system, increased efficiency, and reduced lead time which allow the recovery with high level of purity of base, precious, and special metals along with the self-generation of electrical power, all from low grade WEEE (scrap) and while dealing with all hazardous emissions generated.With the operation of the benchmark recycling plant of METALLICA, UrbanGold will generate 70 skilled jobs and an annual turnover of around 60 million € after start-up. Additional revenues will come from licensing IP rights of technology to potential customers; metallurgical companies/groups, investors, and municipalities interested in a highly profitable, sustainable, and of compact size recycling plant (30,000 tonnes/y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Towards Precision Psychiatry'.

assistant: **Innovation**

The intricacies of the human mind and its disorders are one of the remaining modern-day enigmas. Whereas recent advances in brain imaging and genetics are currently changing the clinical neurosciences by identifying novel general mechanisms of complex traits underlying risk and resilience at the group level, our understanding of individual-level causes and mechanisms of mental disorder has remained almost unchanged which is important because clinical management must be performed at the individual level. During the Marie Sklodowska Curie Actions-Standard European-Individual Fellowship (MSCA-SE-IF) I will address this challenge. Initially, I will expand our innovative normative modeling framework to incorporate information on degree of genetic relatedness (Genetic Normative Model). Similar to growth charts in pediatrics, for which a child’s height is compared to the normative height at her/his age, we describe the distance of each individual in reference to the empirical population/healthy norm of a biological process. We compute this distance while also incorporating information on relatedness quantified by bioinformatic tools based on single-nucleotide polymorphisms across the genome or familiar relationships. We apply this approach in two discrete ways. First, we map the distance between individuals in reference to this norm based on their degree of genetic relatedness (Genetic Mapping), and second, we place individuals showing symptoms of mental disorders in reference to the estimated norm. In this way we can dissect pathophysiological mechanisms on a case by case basis (Disorder Mapping). This individualized approach has the potential to revolutionize our understanding of the heterogeneous mechanisms modulating risk and resilience of mental disorders and requires a j
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'TakiNg actIoN to prevent and mitigate pollution oF groundwAter bodies'.

assistant: **Objectives**

Groundwater is a key resource for water supply which is currently jeopardised by: i) saline intrusion; ii) pollution with pesticides and nutrients (agriculture/farming), pharmaceuticals and antibiotic resistance genes from WWTP effluents, hydrocarbons and heavy metals (runoff), and microplastics (both); iii) global and climate change effects. Although several initiatives have developed actions and tools towards groundwater monitoring and protection, additional knowledge is needed to understand the synergistic effects and risks of multiple stressors and pollutants, and to develop cost-efficient groundwater monitoring strategies, pollution prevention/mitigation technologies, and early-warning DSS. NINFA will provide a novel strategy based on an early-warning DSS and knowledge database (NINFA Platform) and innovaDiffuse pollution affects 35% of the area of groundwater bodies with contaminants such as pesticides, herbicides, and nutrients (leading to eutrophication and lack of oxygen). Other pollution sources, including sewage from wastewater treatment plants (WWTPs) and runoff infiltration in cities (especially during storm events), contaminate groundwater with contaminants of emerging concern (CECs) such as pharmaceuticals, microplastics and antibiotic resistance genes and with hydrocarbons and heavy metals, respectively. Moreover, aquifer exploitation for water consumption leads to increased pressure on groundwater resources, which may be aggravated by climate change (lack of aquifers' natural recharge). In coastal aquifers, this problem is worsened due to saline intrusion, mainly caused by water extraction, which affects the quality of the groundwater.The innovative concept of NINFA is to facilitate the transition to a more effective decision-making system in groundwate