RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Action Plan of Organic Food and Farming', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The overall objective of this project is to give a scientific support in the implementation of the proposed European Action Plan for the further development of Organic Food and Farming in Europe. This will be achieved by the identification of a set of suitable indicators and concepts as a basis for the development of an integrated evaluation tool to assess the long-term and short-term effects of the implementation of the EU Action plan for Organic Food and Agriculture.The project consists of the following specific objectives and work packages:- Development of a toolbox for EU and national administration to evaluate and monitor the implementation of the European Action Plan along the whole food chain for the following areas: information, training and education; research; production, processing, market development, certification, public expenditures;- Testing of the evaluation toolbox on a selected number of ongoing national action plans and identification of conflict areas between national and EU Action Plan targets concluding in policy recommendation to the Commission and national authorities;- Early assessment of potential risks and problems associated with the implementation of the EU Action Plan and test initially the evaluation toolbox on the European level when the European Action plan is in place;- Policy analysis for the implementation processes and procedures;- Recommendations for different actors elaborated with involvement of essential stakeholders.The project partnership consists of 10 partners from 9 countries, covering different disciplines, stakeholder views and experiences with national action plans for Organic Agriculture.The project will strongly support EU and member states in the implementation of Action Plans for Organic Food and farming.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Students of the Arctic' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

According to the most recent surveys on research, science remains far from the daily concerns of a large part of the population and arouses only limited concern among young people. The International Polar Year (03/07-03/09) offers a unique opportunity to exploit this appealing subject in order to give rise to young students for science. Polar science covers a wide range of topics such as arctic biology, meteorology, climatology, oceanography, etc, that are subject to appeal to a large audience. Polar Research is extremely relevant nowadays because it is close related to the global climate change understanding. MOSTRA, the International Polar Foundation and, at a first stage, four TV Networks, offer to work closely in order to produce, broadcast and promote STUDENTS OF THE ARCTIC", a 52' documentary dedicated to life in the University Centre in Svalbard - the northernmost university in the world, at 78° latitude - which will help restore the links between science and the population."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Virtual Earthquake and seismology Research Community in Europe e-science environment' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The earthquake and seismology research, an intrinsically Global undertaking, addresses both fundamental problems in understanding Earth's internal wave sources and structures, and augment applications to societal concerns about natural hazards, energy resources, environmental change, and national security. This community is central in the European Plate Observing System (EPOS), the ESFRI initiative in solid Earth Sciences. .<br/>Global and regional seismology monitoring systems are continuously operated and transmitting a growing wealth of data from around the world. The multi-use nature of these data puts a great premium on open-access data infrastructures integrated globally. Most of the effort is in Europe, USA and Japan.<br/>The European Integrated Data Archives infrastructure provides strong horizontal data services. Enabling advanced analysis of these data by utilising a data-aware distributed computing environment is instrumental to exploit fully the cornucopia of data, and to guarantee optimal operation and design of the high-cost monitoring facilities.<br/>The strategy of VERCE, driven by the needs of data-intensive applications in data mining and modelling, aims to provide a comprehensive architecture and framework adapted to the scale and the diversity of these applications, and integrating the community Data infrastructure with Grid and HPC infrastructures.<br/>A first novel aspect of VERCE consists of integrating a service-oriented architecture with an efficient communication layer between the Data and the Grid infrastructures, and HPC. A second novel aspect is the coupling between HTC data analysis and HPC data modelling applications through workflow and data sharing mechanisms.<br/>VERCE will strengthen the European earthquake and seismology research comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Somitogenesis –  Information transmission by noisy oscillators' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

How do cells communicate robustly despite noise to enable development and homeostasis in multicellular systems? Encoding biological information in signalling pathway dynamics can enhance robustness and signal versatility. Oscillatory activity is a key type of signalling dynamics. Somitogenesis, the periodic segmentation of vertebrate embryos, serves as a model system for studying signalling oscillations in embryonic development. It leads to the formation of somites, transient structures that give rise to vertebrae, axial muscles and other tissues. In anterior unsegmented tissue, single cells commit to differentiation and somite formation. However, our single-cell tracking reveals that oscillations exhibit noise in levels, periods and amplitudes among neighbouring cells. Similarly, in adult tissue homeostasis, i.e., in the small intestine, we recently identified that cell type composition is regulated by signalling oscillation periods, which also vary in parameters between cells. This raises a central question: How is biological information for somite formation and intestinal homeostasis encoded in noisy oscillators?To address this, we developed a toolset for investigating the function of signalling dynamics in tissues at the single-cell level. We will study how signalling is regulated from posterior to anterior unsegmented tissue in mouse embryos by identifying components modulating the oscillatory systems. We will also determine which oscillator features transmit information for somite formation by quantifying dynamic signalling reporters in single cells during differentiation and somitogenesis and testing these features experimentally. Finally, we aim to uncover universal principles of information transmission by comparing mouse with human somitogenesis and with small
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Isotope Fractionation of Light Elements Upon Ionization: Cosmochemical and Geochemical Implications'.

assistant: **Objectives**

Light elements such as hydrogen and nitrogen present large isotope variations among solar system objects and reservoirs (including planetary atmospheres) that remain unexplained at present. Works based on theoretical approaches are model-dependent and do not reach a consensus. Laboratory experiments are required in order to develop the underlying physical mechanisms. The aim of the project is to investigate the origins of and processes responsible for isotope variations of the light elements and noble gases in the Solar System through an experimental approach involving ionization of gaseous species. We will also investigate mechanisms and processes of isotope fractionation of atmophile elements in planetary atmospheres that have been irradiated by solar UV photons, with particular reference to Mars and the early Earth. Three pathways will be considered: (i) plasma ionisation of gas mixtures (H2-CO-N2-noble gases) in a custom-built reactor; (ii) photo-ionisation and photo-dissociation of the relevant gas species and mixtures using synchrotron light; and (iii) UV irradiation of ices containing the species of interest. The results of this study will shed light on the early Solar System evolution and on processes of planetary formation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Next Generation Instrument for In-Depth Analysis of Mitochondrial Fitness' (NextGen-O2k), addressing dissemination and exploitation.

assistant: **Impact**

Mitochondria and chloroplasts are key elements to face the new challenges of the millennia for biomedicine, biotechnology and to develop a sustainable bio-economy. Mitochondrial fitness is a key parameter for diagnosis and therapeutic applications on multiple human pathologies, such as neurodegenerative diseases, diabetes and cancer. On the other hand, the optimization of algal growth rate and metabolite production in biotechnology requires novel investigations and monitoring of the bioenergetic pathway control exerted by mitochondria and chloroplasts. However, current technologies to study mitochondrial and chloroplast function are limited, providing segmented information, lacking inter-laboratory reproducibility and hindering our advance towards therapeutic and biotech interventions of cellular bioenergetics. As a result, the understanding of cellular bioenergetics for medical and algal biotechnology applications remains poor. The overall objective of this project is to complete the development of NextGen-O2k and prepare its market launch in 2021. NextGen-O2k is a multi-sensor platform for in-depth study of mitochondrial and chloroplast functional fitness. In a compact and affordable device, we have integrated several sensors for detecting multiple key parameters of bioenergetics, with superior resolution and reproducibility. With NextGen-O2k we will provide researchers with a tool able to improve knowledge about mitochondrial dysfunction and chloroplast photosynthesis, while bringing savings in experimental time, samples and funds. NextGen-O2k project is a step forward towards understanding mitochondrial implication in human pathologies and in the optimization of biomass production in many areas of biotechnology. Our focus in on generating knowledge about mitochondri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Numerical Modelling of seismic wave propagation in complex geological structures'.

assistant: **Concept**

The propagation of seismic waves through the Earth can nowadays be modelled accurately with the recently developed spectral-element method. This method takes into account heterogeneity in Earth models, such as three-dimensional variations of seismic wave velocity, density, and crystal thickness. The method is implemented on relatively inexpensive clusters of personal computers, so-called Beowulf machines. This combination of hardware and software enables us to simulate broadband seismograms without intrinsic restrictions on the level of heterogeneity or the frequency content.Using large-scale computers such as parallel machines, we can simulate the propagation of seismic waves in complex three-dimensional geological structures, and also take into account complex effects such as anisotropy, attenuation, self-gravitation and the rotation of the Earth. By performing such very high-resolution numerical simulations, we plan to produce maps of ground motion during earthquakes occurring in densely populated regions. Such maps can be particularly useful in the context of seismic risk assessment.We also plan to go to the next level in terms of numerical simulation of seismic wave propagation on parallel computers by taking advantage of grids of computers, i.e., geographically distributed clusters of very large computers (called GRIDS") that can be seen and used as an equivalent parallel machine of very large size. Using such large machines will allow us to model seismic wave propagation in complex three-dimensional structures at very high resolution."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'How long have human activities been affecting the climate system?' (EARLYHUMANIMPACT) under Seventh Framework.

assistant: **Objectives**

Human activities are altering the global climate system at rates faster than ever recorded in geologic time. Ample observational evidence exists for anthropogenic climate change including measured increased in atmospheric CO2, temperature and sea level rise. Biomass burning causes CO2 emissions of ~50% of those from fossil-fuel combustion and so are highly likely to influence future climate change. However, aerosols continue to be the least understood aspect of the modern climate system and even less is known about their past influence. Anthropogenic aerosols may have altered the global climate system for thousands of years as suggested by comparing late-Holocene greenhouse-gas concentrations to those from previous interglacials. The decrease in the spatial extent of forests beginning ~8000 yrs BP may be related to early agricultural activity including forest clearance through burning which should leave a quantifiable signal in climate proxies.We pioneered a ground-breaking technique for determining a specific molecular marker of biomass burning (levoglucosan) which can record past fire in ice cores and lake sediments. The research incorporates continuous ice and lake core climate records from seven continents with parallel histories of fire regime. These can provide essential insight into the interplay between climate and human activity, especially with the advent of agriculture. Key objectives include:1) How does biomass burning change through time and space?2) How do climate parameters respond to or correlate with changes in biomass burning?3) Did fires increase ~8000  and/or  ~5000 years ago?4) Can natural and anthropogenic fires be differentiated? If so, how do fires and associated climate change ascribed to human activity differ from natural biomass burning?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a hybrid injection moulding process for sme moulders to produced glass / polymer composite parts, at high volume' to be submitted under Fourth Framework.

assistant: **Abstract**

Rubber is one of the basic materials used in the manufacture of soles and sole components for footwear (soles, top-pieces, heels, socks, etc.). The many possibilities which the material offers with regard to the adaptation to different wear purposes, from high performance footwear (military, professional, sports), to medium or low performance footwear (street, fashion, indoors, etc), makes it an indispensable material in this industrial sector, with a consumption level exceeding 25% of the total footwear produced. However, the rubber has to be vulcanised in order for it to be used subsequently and this operation is traditionally carried out in the footwear industry statically way by means of hot-plate presses, which unfavourably increases manufacturing times and energy consumption. This involves slow, unflexible and costly manufacturing processes which greatly limit production. The main objective of the project is to develop an alternative system to the traditional processes of rubber vulcanisation in the footwear industry, by means of microwave technology. For this, a pilot scale microwave oven prototype will be designed and built as well as microwave transparent moulds and rubber compounds sensitive to their heating action. All these elements will allow the vulcanisation of rubber components for footwear in a continuous manufacturing system. Microwave technology offers many advantages as compared to traditional processes: direct heating of the rubber mass and not of the moulds, faster, more even and selective heating, higher performance, less energy consumption, better quality and reproducibility of the finished product, less energy leakage to the environment, cleaner, less space for the installation, easier maintenance, electronic operation and control, automation ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Human Security in the Western Balkan region: the impact of transnational terrorist and criminal organisations on the peace-building process of the region' (HUMSEC).

assistant: **Concept**

The main purpose of the coordination action HUMSEC is to contribute to a better understanding of the link between trans-national terrorist groups and criminal organisations in the Western Balkans and their role in the peace-building process in the region.The project will set up a network of European researchers with the aim:- to map and integrate European research capacities on the impact of trans-national terrorist groups and criminal organizations on the peace-building process in the Western Balkan region;- to develop a shared methodology of collecting facts and figures;- to promote an interdisciplinary scientific dialog among experts in the field of terrorism, criminology, security studies, peace and conflict studies and human rights;- to exchange experiences as well as different proposals for legal and institutional reforms;- to coordinate and publicize the results of research in courses held with young professionals and representatives of the civil society and among policy-makers.A key element of the courses will be to strengthen democratic principles and to raise awareness on the impact of trans-national terrorist groups and criminal organizations on the peace-building process in the Western Balkan region by means of human rights education and education for democratic citizenship. Moreover, an Internet platform will be created to facilitate the scientific dialog, publications will be released and a dissemination meeting will be organised to present the results of the project to policy-makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Discovery of anticancer polymeric drugs that mimic the action of TRAIL'.

assistant: **Innovation**

Biopharmaceuticals such as monoclonal antibodies (mAbs) and interferons/cytokines have become mainstream since the approval of recombinant human insulin in 1982. However, many challenges such as production costs, output capacity and demanding storage conditions prevent them from realizing their full potential. Therefore, the objective of this action is to develop a polymeric drug (PolyDrug) that mimics the activity of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) for the treatment of breast cancer. To do this, multivalent polymers that display peptides (binding epitopes) with high affinity for death receptor 5 (DR5) will be prepared in high-throughput using combinatorial polymer chemistry. Then, the modern drug discovery process will be applied to identify/develop PolyDrugs with the greatest anticancer potential. This includes library preparation in Work Package 1 (WP1), high-throughput screening and hit to lead in WP2, and lead optimization through cell studies and macromolecular modeling in WP 3. Beyond this scope of this action, these efforts will be followed by preclinical and clinical development within a start-up PolyDrug discovery company. With this innovative PolyDrug discovery process, I hypothesize that I will be able to develop polymeric replacements for current biopharmaceuticals including TRAIL.