RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Non commutative geometry and quantum gravity'.

assistant: **Innovation**

The project aims at deepening the relationship between various approaches to quantum gravity and noncommutative geometry.Indeed there is a strong theoretical evidence that the usual continuum model of space-time is not correct at very short distances where both gravitational and quantum mechanics effects come into play. Several theories propose a (incomplete) treatment of quantum gravity, but even the most popular of them (string theory, loop quantum gravity) have not been experimentally tested for the energy scale corresponding to the Planck length is far beyond our experimental possibilities. However it has been stressed that quantum gravity theories, by giving a non continuum structure to space-time, may lead to some observational effects. Most of the time this non continuum structure has a mathematical translation in terms of  quantum, or non commutative, spacetimes. Namely one posits a noncommutative algebraic structure of the coordinates of spacetime by a deformation of the classical algebra, just as quantum groups are deformation of classical Lie algebras.However the physical status of such space-times is not clear. Naive questions like ""what are the points of a quantum space-time ?"", ""what happens to the notion of distance ?"" have no clear answer.These questions are addressed by the conceptual approach to Noncommutative Geometry (NCG) developed by Connes. NCG provides a formulation of standard geometric and topological concepts (like spin and differential structures) within a purely algebraic framework. Riemannian geometry is encompassed as a particular case, commutative, of a more general theory.The project aims at deepening the relation between the more down-to-earth-approach to quantum space-time developped by theoretical physicist on the one side, and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Characterization of a protein export machinery of the endoplasmic reticulum' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Selective proteolysis of aberrant or highly unstable proteins within the cytoplasm of eukaryotic cells depends on the ubiquitin/proteasome pathway. The same pathway has recently been shown to be also involved in the degradation of various proteins residing in the endoplasmic reticulum (ER). Integral proteins of the ER membrane may be be directly accessed by the ubiquitin/proteasome degradation machinery via their cytoplasmic domains. However, the breakdown of soluble proteins within the ER lumen and of the luminal parts of integral membran proteins must de. end on a so far unknown re-export apparatus, which specifically translocates these proteins into the cytoplasm prior to proteolytic degradation. The aim of this proposal is the characterization of factors required for the selective degradation of ER proteins and the isolation of components of a protein re-export machinery from the ER into the cytoplasm. The work will be carried out in the yeast Saccharomyces cerevisiae, which is suitable for genetic and biochemical analysis. Results obtained in the course of this work should provide general insights in the control and catalysis of the breakdown of proteins localized within cellular organelles. Training content (objective, benefit and expected impact) A research stay at the M.D.C. will help me to complement my present training in yeast genetics and microbiology with biochemical techniques and combine my experience obtained during the work on yeast mitochondrial biogenesis with the research on ER protein turnover. I will aquire new biochemical knowledge which will enable me to establish novel projects on eukaryotic organellar biogenesis in the future. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ultrasound activiated nanoencapsulated targetted drug delivery and tumous cell poration' in the context of a Seventh Framework call.

assistant: **Objectives**

Clinical drug delivery (DD) remains a problem of heightened industrial and academic interest.  The proposed partnership seeks to embrace the problem by exploiting the unique expertise-base spanning the industrial research and academic pratners. We will provide inter-sectoral training of mulit-disciplinary researchers and create a novel new DD modality that addresses the key critical needs for non-invasive therapy via intelligent generic targeting and with intrinsic flexibility in drug choice.  An essential simplicity to the present approach is that it takes strands of intrinsically safe technologies, and marries these into a powerful amalgam that offers true power and enhanced versatility. Chief amongst the areas of research are: (i) A generic encapsulating technology [CapsuTech - industrial partner] that will vector active anti-cancer drugs to a tumour target; (ii) Remotely triggered drug release on demand by externally focused ultrasound energy [development by industrial partner Insightec](iii) Enhanced drug uptake through the parallel disruption of cell membranes by the action of ultrasound on commercially available microscopic bubbles [sonoporation - University of Dundee]. The Dundee Group, who will lead this partnership, has made significant inroads to fundamental understanding with this latter strand.  Moreover, the partners have gone to great lengths to factor in a level of training that also embraces existing trends for image guided intervention:  in particular with magnetic resonance imaging (MRI). The project objectives we have realized are fully compatible with MRI technology and indeed, this prescience endows the overall scheme with significant added value. We anticipate that this synergistic and intra-sectoral multi-disciplinary research partnership will cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Centre of Excellence for Biomolecular Research'.

assistant: **Innovation**

Life Science research has become increasingly digital, and this development is accelerating rapidly. Biomolecular modelling techniques such as homology modelling, docking, and molecular simulation have advanced tremendously due to world-leading European research, resulting in extreme demands for better computational performance and throughput as these tools are used in applied research and industrial development. This research has direct influence on our daily life in areas such as health and medical applications, the development of new drugs, efficient drug delivery, biotechnology, environment, agriculture and food industry. Life Science is one of the largest and fastest growing communities in need of high-end computing, and it is a critically important industrial sector for Europe. However, compared to some other disciplines, the use of e-Infrastructure is still relatively new - many advanced techniques are not applied commercially due to limited experience. It requires significant support to:• Make e-Infrastructure useable by researchers who are not computing experts,• Improve the performance and applicability of key life science applications,• Handle large amounts of data in computational workflows.BioExcel proposes to tackle these challenges by establishing a dedicated CoE for Biomolecular Research, covering structural and functional studies of the building blocks of living organisms - proteins, DNA, saccharides, membranes, solvents and small molecules like drug compounds - all areas where with large academic and industrial users bases in Europe. Specifically, BioExcel will• Improve the efficiency and scalability of important software packages for biomolecular research;• Improve the usability of ICT technologies for biomolecular researchers in academia and industry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Photo-induced heating of Lithium-ion batteries for Low Temperature Operation'.

assistant: **Innovation**

Lithium-ion batteries (LIBs) are currently the most versatile all-purpose energy storage solution. However, LIB performance is strongly affected by temperature. In particular, at sub-zero temperatures, LIB performance is dramatically reduced. This is detrimental for LIB deployment in cold climates found in Northern Europe or high-altitude mountainous regions and hinders their widespread use in airplanes, high-altitude aerial vehicles and military and aerospace applications. The PLuTO project aims to develop a new viable approach to improve LIB performance at low temperatures. To this end, the PLuTO project will forge a photo-induced heating route for low temperature operation of liquid electrolyte batteries by incorporating in-situ synthesized noble metal nanoparticles suspended in the electrolyte, harnessing the nanoparticles capability to efficiently and quickly heat up when illuminated by light. Moreover, with a proper distribution of nanoparticles, uniform heating will guarantee a safe operation of the cell. The PLuTO project aims at achieving a first-time demonstration of photo-induced heating in a liquid electrolyte battery by using a transparent electrochemical cell with a LiFePO4 cathode (chosen due to its recognized stability at extreme temperatures). A balanced approach between computational modelling, chemical synthesis, fabrication and characterization will be implemented to investigate the influence of photo-induced heating in the electrochemical processes of the LIB cell and identify design rules for a suitable practical implementation in industrial/commercial applications. Finally, the research proposed within PLuTO is strategically positioned at the intersection between the optical-thermal-electrochemical fields and provides an excellent opportunity for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Wireless Alliances for Testing Experiment and Research', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Very and Ultra high speed radio platforms are key developing technologies for emerging applications but raise issues of efficient radio spectrum management and interoperability of technologies, from radio to media access control levels. Among these radio platforms, Ultra Wide Band (UWB) is a very promising technology for the broadband transmission of data using spectrum efficient and flexible radio techniques. Initiatives such as the WiMedia Alliance have developed concepts to use UWB as a standard radio platform allowing transport of upper level protocols such as the wireless USB (WUSB), wireless Firewire and the next generation of BluetoothThe European Telecommunications Standards Institute (ETSI) is producing harmonised standards to foster UWB adoption in Europe but Europe is still late compared to USA and others. If not corrected, such a situation could hinder the European innovation potential to develop new applications and services based on this extremely high capacity networks.To pursue the needed European standardisation and regulation efforts, while reinforcing the European leadership in the field of wireless networks, a new range of UWB testbed has to be developed.The WALTER project will address this need and overcoming the associated technological issues of measuring ultra-high frequency signals; will develop a pan-European interconnected testbed. This testbed will make use of the strong European expertise in conformance and interoperability testing. Based on a deep needs analysis and specifications definition, it will be flexible enough to address both from short-term needs (industry and regulators) to long-term needs (research communities), while allowing testing of mitigation techniques.The deployment of this testbed will be supported by dissemination acti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New generation of ion sources: from deep space missions to upstream nano-technologies' (NEPTUNE) targeting Seventh Framework.

assistant: **Abstract**

The main goal of the proposed NEPTUNE project (“New generation of ion sources: from deep space missions to upstream nano-technologies”) is to enhance the understanding of the physics and exploit the benefits of bipolar charged particle extraction from low temperature plasma. The first NEPTUNE prototype will be built and tested during the project implementation. In the NEPTUNE prototype the generated particle beam will be quasi-neutral, composed by ions and electrons or oppositely charged ions, without the need for an additional neutralization system.The NEPTUNE project brings together scientists who are experts in the area of formation of flows of oppositely charged particles, in order to address key fundamental issues at the leading edge of the subject: simultaneous bipolar particles extraction, space charge neutralization in complex systems and plasma - bipolar beam interactions.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of subcutaneous Adipose tissue as a secretory organ in critically Ill patients' (SURVIVE-ICU) targeting Sixth Framework.

assistant: **Abstract**

Systemic inflammation contributes to the development of multiple organ dysfunction, the major cause of mortality in patients with septic shock. Systemic inflammation is a consequence of activation of the innate immune system. Recent studies have indicated that adipose tissue plays a major role in the secretion of inflammatory factors, which have been called adipo-cytokines or adipokines.Also, the increased production rate of cytokines such as IL-6 or TNF-alpha has been implicated in the pathogenesis of car diovascular complications and insulin resistance. However, the metabolic role and possible consequences of adipose tissue as a secretory organ in critically ill patients has not been investigated to date. For the present proposal we will test the hypothesis, that adipose tissue is one of the links between systemic inflammation causing insulin resistance in critically ill patients and low-grade inflammation causing insulin resistance in obesity. To test this obesity we will characterize adipose tissue as a secretory organ using interstitial fluid sampling techniques and advanced peptide analysis in critically ill patients and healthy controls.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Interaction in eu climate policy (INTERACT)' (INTERACT).

assistant: **Concept**

Interaction between different policy instruments is of growing significance to the integration of sustainability into all areas of EU policy. Interaction can be complementary and mutually reinforcing, but there is a risk that different policy measures may interfere with one another and undermine the objectives and credibility of each. INTERACT will develop a methodology for systematically analysing such interaction issues, and use this to explore interaction between Kyoto mechanisms and other climate policy instruments in the EU. In so doing, it will make recommendations on the design, implementation and reform of Member State and EU climate policy, with the aim of ensuring it operates efficiently and effectively and exploits positive synergies between instruments. In particular, it will make recommendations on the implementation of Kyoto mechanisms, and suggest how the interaction analysis technique can be applied to other policy areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Part to Play: How Caregivers Shape Infants' Visual Exploration and Alter Their Neural Mechanisms of Attention' (InterPlay) targeting Horizon 2020.

assistant: **Abstract**

Infants learn and develop at incredible speed. Although relatively helpless at birth, infants undergo significant development in the first year of life in many domains. But how do infants learn so quickly? They likely gather information that is optimal for learning by systematically allocating their visual attention to specific types of stimuli. Allocation of visual attention can be (1) intrinsically driven to guide their explorations in the world, or (2) guided by other social agents. Moreover, infants’ intrinsic visual exploration may be dependent on the “hardware”: the brain. This project aims to develop a comprehensive account of how these mechanisms interact in full-term and pre-term infants. Visual exploration and attention is often disrupted in pre-term infants, which may contribute to developmental delays. Since the World Health Organization estimates that 15 million infants are born pre-term annually, it is crucial to investigate how infants visually explore their environment and how this can be promoted through social interactions. Research into infants’ visual attention has been conducted by scientists from various fields, but few attempts have been made to integrate these findings into a comprehensive framework. As such, the interplay between these factors remains unknown. This lack of integration causes severe gaps in our theoretical understanding, hindering the development of healthcare policies and interventions. InterPlay addresses these knowledge gaps by integrating previous observations into a comprehensive, longitudinal study. The findings will have implications for current scientific and therapeutic practices. If caregiver attention-guiding behaviours could compensate disruptions in pre-term infants’ visual exploration, this would offer great potenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Temperature Perception in Crop Plants', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of this proposal is to discover components of the ambient temperature perception pathway in Brachypodium distachyon. This will help us understand the way in which crop plants perceive and respond to changes in ambient temperature, including climate change. A gene expression atlas for the major ambient temperature responses in Brachypodium will be created using microarrays, to identify genes that show a continually variable expression across the ambient (i.e. non-stress inducing) temperature range. These experiments will be compared to data from Arabidopsis to identify the level of conservation in temperature perception pathways between monocots and dicots. The promoters of temperature responsive genes identified through this analysis will be fused to the firefly Luciferase gene to develop ambient temperature reporter lines. Selected lines will be used in forward genetic screens (using fast neutron irradiation mutagenesis) to identify key components of the Brachypodium temperature sensing pathway. This analysis will be complemented by functional characterisation of temperature sensing genes identified in parallel screens in Arabidopsis that have been carried in the Wigge lab as well as using the expression atlas data. These reverse genetics approaches will use RNA interference technology to knock-down the activity of the genes of interest. The phenotypes of these plants will be assessed to determine the direct role of each candidate within the temperature perception pathway. Taken together, this project aims to provide novel information about the way in which our major crop plants will respond to changes in ambient temperature by continuing the development of Brachypodium as a model organism for temperate cereals, such as wheat and barley, and identifying g