RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Toxoplasma gondii secretes an armada of effector proteins to co-opt its host cell transcriptome and microRNome to promote sustained parasitism' (HostingTOXO).

assistant: **Concept**

Toxoplasma gondii is a widespread obligate intracellular protozoan parasite causing toxoplasmosis, a severe disease in immunocompromised or congenitally infected humans. It can infect any type of nucleated cells and grow inside a parasitophorous vacuole (PV) from where it directs profound changes in their transcriptome, proteome and microRNome. During invasion and creation of the PV membrane, apically oriented organelles called micronemes and rhoptries are discharged, followed later by release of dense granules content (DG). Recent advances have highlighted few strain-specific parasite effectors released from the rhoptry into the host cells where they neutralize cell autonomous immunity defences or subvert the host cell transcriptome thereby governing the fate of immune response and disease outcomes. Considering the magnitude of the repertoire of mRNA- and microRNA-encoding genes that is differentially regulated in host cells, it seems certain that other critical rhoptry- and DG-resident proteins that interact with host signaling pathways await discovery. By integrating diverse genomic-scale analyses and using reverse genetic, we identify novel DG proteins that are singularly exported beyond the tachyzoites-hosting PV to the host cell nucleus, thus extending the scope of the function of DG proteins beyond their dedicated role in vacuole formation. This collection of novel parasite effectors will be invaluable towards our goal of understanding how T. gondii actively remodels the genome expression of its hosting cell with profound and coupled impact on both parasite developmental process and the host immune response. We propose i) to characterize thoroughly the function of novel effector proteins secreted by T. gondii and ii) to explore how their synergistic or antagonist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Challenging the Standard Model with the scrutiny of b to qll transitions'.

assistant: **Objectives**

Today, Particle Physics is in an unusual situation with a theory, the Standard Model (SM), able to accurately describe a very large number of precise measurements but at the cost of ad hoc features in the fermionic sector. Furthermore, the SM is unable to answer key questions raised by cosmological observations. Consequently, the ball is now on experiment side to search for signs of non-SM physics (NP). The most straightforward way to hunt for NP particles is to seek for their signatures directly in the data, but none of them has been found today. Therefore, this project focuses on indirect searches which rely on the quantum nature of particles. Since b-hadrons study is an ideal field for this type of searches, I propose to explore the Flavour-Changing Neutral Currents b-> sll  and b-> dll transitions to draw the identity card of the NP particles which may be at play. Due to experimental constraints, our current knowledge is limited: the published results are mostly related to the b-> s mumu transitions and the observations of b-> see are rare. With the Chiaroscuro project, I will be able to study for the first time the angular properties of the decay products of the b-> s ee transitions over the full kinematical domain for a variety of b-hadrons to investigate the NP couplings to the electron (e) and muon (mu) particles. Another important question is the coupling of NP with the quarks of the first and second families: are the b->sll and b->dll transitions impacted the same way by NP? In order to answer this interrogation, I will study Lb and Bc hadrons decays - uniquely accessible at the LHC - using cutting edge reconstruction techniques.The project will use the LHCb detector running at the LHC to benefit from the huge b-hadron production rate. In order to cope with th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A NOVEL SYSTEM TO BREAKDOWN HAZARDOUS SUBSTANCES IN WASTE WATER STREAMS INTO HARMLESS BIO-FRIENDLY COMPOUNDS USING MULTI-CHROMATIC UV LIGHT' (LIGHT4CLEANWATER), addressing dissemination and exploitation.

assistant: **Impact**

There is a need to mange Europe’s finite water resources. Water discharged from industrial processes needs to be returned into our environment in a safe and clean state. This is reflected by the Water Framework Directive (EC 2455/2001/EC) and other legislation. Over 7,000 million cubic metres of heavily polluted water are discharged by our targeted industries every year in Europe, existing technologies that are used to address this issue do not resolve this problem in a satisfactory way, they simply just remove the problem for further environmentally unfriendly treatment elsewhere. Our technological concept is to develop an industrial wastewater treatment system for the removal of complex organic pollutants by advanced oxidation without chemical additives using a polychromatic light in the UV and VUV range. Basic research work has validated the feasibility of our approach and our proposed solution. Further innovations by us will be in; enabling effective breakdown of organic pollutants in waste streams into harmless material, without the use of chemical additions (measured by total organic carbon – TOC), using a novel, reliable and cost-effective polychromatic excimer UV and VUV source for in-line operation, with associated development of an on-line (TOC) sensor and process control to ensure clean continuous discharges from waste streams. With a potential market for our system in the priority sectors we have selected of over €550 million pa (EU27) and  €10 billion globally, we anticipate that within 5 years post project we can save EU industry over €14 billion pa. and generate direct sales revenue of €45 million for our SME partnership led by our SME coordinator (SICO Austria). Our proposed system will be able to safely and cheaply treat toxic organic waste streams; bre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Business strategy of nanofluidic chips for next-generation bioanalysis solutions to develop future medicines' (Envue), addressing dissemination and exploitation.

assistant: **Impact**

Envue Technologies is a Swedish deep-tech spin-out developing next-generation optical microscopy technology to achieve a deeper understanding of the building blocks of life - biomolecules such as proteins, DNA and RNA. Using a state-of-the-art combination of nanotechnology, light, and data analysis, we are at the forefront of studying single biological nanoobjects that are fundamental in life science segments such as drug discovery and development. Our patent-pending innovation, Nanofluidic Scattering Microscopy (NSM), enables a unique ability to visualize and analyze biomolecules in their native and natural state, without making any modifications to them to improve the efficiency and precision of future drugs. The core of our NSM solution is to use nanochannels in our fluidic chips as tiny optical sensors.The objectives of this proposal are to evaluate and develop our (i) production process, (ii) business model, and (iii) IP protection related to our nanofluidic NSM chips and to define the best business track and strategy for the company. This is accomplished by evaluating three options for nanofabricating the chips, establishing a maximum volume in-house production process, conducting a market analysis to understand stakeholders, conducting a patent search, and an FTO analysis related to the design and/or the function of the chips. Our goal is to commercialize NSM for a global audience, which requires long and expensive R&D processes with technical expertise. This project will therefore provide the resources and support for the next essential step in our innovation development, to significantly strengthen our position towards investors and to prepare the first round of investments to further develop and grow the company.


**Keywords:** Bioanalytics, Biopharma, Life S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synergistic Modelling of Molecular Effects via Chemical and Biological Data Integration' (MIXTURE).

assistant: **Innovation**

While conventionally effects of a chemical structure on a biological system have been determined for individual compounds, one at a time, it is now becoming apparent that biological effects of compound combination are not additive, but often conditional (antagonistic or synergistic) in nature. This phenomenon is of relevance both in the medicinal context (where drugs can be combined to have a synergistic effect), as well as the area of toxicology (where the simultaneous application of compounds shows a toxicity that is non-additive). However, it is not yet clear how to model, and anticipate, which compound combinations show this type of effect.Hence, in this work I will derive models of synergistic compound combinations, which will be prospectively validated in experiments. Furthermore, I will describe how to capture the effect of a chemical structure on a biological system on multiple levels, namely by considering structural features of the compound, its bioactivity profile, and pathway annotations and their relationship to the phenotypic effect observed. By integrating the data generated in a biologically meaningful way, this allows us to generate predictive models for the bioactivity of compound combinations. The relevance of this work ranges from the question which drugs can be combined in a synergistic manner and which combinations should rather be avoided to the safety assessment of chemicals. Hence, with this work I will be able to improve upon the current state-of-the-art in bioactivity data integration and modelling approaches, as well as deliver concrete models for the bioactivity assessment of compound combinations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Predictive Energy Management in Plug-in Hybrid Electric Vehicles' in the context of a Horizon 2020 call.

assistant: **Objectives**

Plug-in hybrid vehicles (PHEV) offer an ample alternative for low-carbon road mobility, which however impose a significantly challenge on maximising energy efficiency and driving autonomy. This pPHEV project aims at addressing this challenge by developing a predictive energy management system for PHEVs as well as realise an advanced career development for the experienced researcher using a clearly defined training-through-research approach. This proposed predictive control management will benefit from and integrate driver driving style information, and dynamic traffic and speed information within this project, along with a few on-going vehicle electrification and intelligence research activities at Cranfield University. This fellowship provides an excellent opportunity for the experienced researcher to advance the career training to secure a leading independent position at the end of the fellowship. The research outcomes will offer a step change in PHEV energy management, and promote knowledge sharing among different EV/HEV-related communities. The pPHEV project will not only advance the research, innovation and development of future PHEVs, but will also improve public awareness of smart green transport.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fourth Mediterranean Programme Summer School. Migration in the Euro-Mediterranean Area: Demographic, Economic, Legal, Political and Social Dimensions' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The proposal is for a Summer School of 10 days' duration (8 full working days), entitled: Migration in the Euro-Mediterranean Area: Demographic, Economic, Legal, Political and Social Dimensions.International migration is a key dimension of the construction of a peaceful and prosperous Euro-Mediterranean area. What motivates migration - the search for more material welfare, political freedom, or physical security signals particular features of the sending countries, such as pressures exerted by mal-development or rising insecurity, or strategies for integrating into the world economy through labour mobility and networking. It also signals the existence of differentials between sending and receiving countries, in terms of economic conditions or political situation. Finally, it signals the availability of routes from departure to arrival countries, whether through legal procedures or illegal channels.Migration is major factor of change. In sending countries, emigration can promote a wide range of transformations, from the various economic impacts of expatriate workers' remittances, to the emergence of new middle classes, the reinvention of identities and the diffusion of alternative models and behaviours, including political ideals and the various ways through which diasporas can influence politics in home countries. In receiving countries, immigration can also prompt changes in areas such as demographic growth, the balance of the labour market and employment, social welfare, security, integration of ethnic diasporas and religious communities. It may also lead to the adaptation of legal provisions or to new political debates.Lastly, international migration is a component of international relations. Regulating movements across borders, containing trafficking, redefining cit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DataCube Service for Copernicus' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Copernicus has boosted the availability of Earth Observation data both in terms of quality as well as quantity. This has, on the one hand, unleashed new opportunities for intermediate business users (IBUs), who provide services to an inherently diverse group of end users. On the other hand, however, the handling of big data volumes, the integration of data streams from different sources, and the generation of high-quality information from the novel sensors of the Sentinels pose significant technical and scientific challenges to many IBUs. The lacking expert skills often hinder the user uptake of Copernicus products and services and eventually impede economic growth of the sector.The DataCube Service for Copernicus project (DCS4COP) addresses these obstacles by implementing the Copernicus Water DataCube Service (CoWaDaCS) - the first instance of a new service model, integrating Sentinel data, Copernicus Service data and user supplied data in a DataCube system. The offered service comprises Processing as a Service (PaaS), Software as a Service (SaaS), consultancy and training. It is targeting the value-adding Earth Observation industry and public organisations at highly competitive costs and with user-friendly interfaces, which can be tailored to specific needs.Capitalising on the scientific achievements of the recent FP-7 funded HIGHROC research project and operated by experienced service providing institutions, CoWaDaCS will demonstrate the value of satellite Earth Observation data for the market segment of coastal and inland water services. Currently this market is largely underexploited due to market blockages and offers a large growth potential. The combination of access to high quality data, wide selection of thematic data layers, state-of-the-art tools and unrivall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The hypothalamic control of behavioral and physiological adaptations to stress', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

When faced with threats to their survival, animals execute flexible behavioral adaptations specific to each threat, such as escaping a predator. These behaviors are accompanied by brain-driven physiological changes, including elevated heart rate, blood pressure and respiration, which are critical for meeting the increased energy demands during stress. While behavioral responses to threats have been extensively studied, the neural mechanisms that coordinate the accompanying physiological changes remain poorly understood. Additionally, it remains unclear how the brain orchestrates behavioral and physiological adaptations in tandem. HypoAdapt aims to bridge this knowledge gap by investigating the organization and function of the hypothalamus — a critical brain region responsible for both behavioral and physiological responses to homeostatic challenges. Specifically, we will focus on the dorsomedial hypothalamus (DMH) through the following aims. Aim 1: Decipher the anatomical and functional organization of the DMH circuitry that controls responses to distinct stressors. Aim 2: Define how inhibitory inputs to the DMH control the dynamic execution of behavioral and physiological responses with precise timing and vigor. Aim 3: Discover the role of neuropeptide inputs to the DMH in regulating stress state by modulating the underlying neural circuits. By employing cellular resolution neural imaging, machine-learning-based behavioral tracking, monitoring of physiology and neural circuit mapping and manipulations, HypoAdapt will be the first study to offer a holistic view of the neural circuit mechanisms underlying survival adaptations to threats. These findings will illuminate general principles underlying brain-controlled processes that require both rapid and long lasting regula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Evaluation of the immunotoxicity of mercury, zinc, polychlorobiphenyls and methyl sulfonyl polychlorinated biphenyls on cytokine and proteome expression in marine mammals' (PHOCOENA2004), addressing dissemination and exploitation.

assistant: **Impact**

Harbour porpoises (Phocoena phocoena) and harbour seals (Phoca vitulina) can display high levels of zinc (Zn), mercury (Hg), polychlorinated biphenyls (PCBs) and methyl sulfonyl metabolites (MeSO2-PCBs) in their tissues. Little is known about potential imp act of these pollutants on marine mammal immune system. The proposed study aims to better define the immunotoxicological risk linked to an exposure of the harbour porpoise and the harbour seal to methyl-Hg, Zn, PCBs and MeSO2-PCBs. Harbour seal and harbour porpoise peripheral mononuclear blood cells (PMBC) will be isolated (task 1) and contaminated with methyl-Hg, Zn and PCBs (task 2). The expression of cytokines (task 3) and the study of the proteome (task 4) will be studied in control and contaminated PMB C.- Task 1. PMBC will be isolated from the blood of captive and wild harbour porpoises and harbour seals and kept on cell culture medium. Analysis of Hg, Zn, PCBs and MeSO2-PCBs will be realized in the blood and serum of wild harbour porpoises and harbour seals from the North Sea to evaluate their contamination level.- Task 2. PMBC will be contaminated in vitro with methyl-Hg, ZnCl2 and PCB solutions. The tested concentrations will be in the range of concentrations naturally occurring in the blood of wild h arbour porpoises and harbour seals. - Task 3. The expression of pro- inflammatory (IL-1ß, IL-2, Il-6 and TNF-a) and anti-inflammatory (IL-10 and TGF- ß) cytokines will be investigated using RT-PCR and real-time RT-PCR. Cytokines are glycoproteins secreted by the immune cells and their expression is one important tool for the characterisation of the cellular immune response. - Task 4. In complement to cytokine mRNA expression, we wish also to understand pollutant effects on a ¿protein¿ level. Proteomic will allow