RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Communication strategy and tools for optimizing the impact of Ebola vaccination deployment – Sofia ref.: 115847' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Communication strategy and tools for optimizing the impact of Ebola vaccination deployment.The EBODAC consortium consists of 4 partners: Janssen (EFPIA), London School of Hygiene and Tropical Medicine (LSHTM), World Vision of Ireland and Grameen Foundation . These partners have experience and expertise in:• (Ebola) vaccine development and vaccine acceptance; m-health deployments for disease management in resource limited settings (Janssen)• Vaccine acceptance; risk management in health programs (LSHTM)• Mobile health deployments for emergency assistance; communication and training delivery in emergency settings (World Vision)• Mobile health software development and deployment in resource limited settings (Grameen)As such, the EBODAC consortium is well placed to tackle the challenges associated with Ebola vaccine deployment, including:• Stigma related to Ebola infections• Lack of understanding and distrust versus vaccines in general in the local endemic communities• Two step prime/booster regimen for Ebola vaccine: risk for a ‘no show’ for the booster shot, risk for presenting for the booster shot too early or too late; risk for a different person presenting for the booster shot vs. the prime shot• People may be difficult to reach for the vaccine recall; People may live at a large distance from the health center where the vaccine is delivered• Risk for data on vaccine coverage to be fragmented, not existing or incorrectThe EBODAC consortium is committed to deliver:• A communication strategy that will optimize vaccine acceptance, supported by local anthropology research data• A platform, based on mobile phone technology, for Ebola vaccine recalls, information/education on Ebola and vaccines in general; and tracking of vaccination coverage• An identification tool to allow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The Legitimacy of Multi-level Human Rights Judiciary'.

assistant: **Concept**

The proliferation of human rights treaties at regional and global levels may offer moral foundations for international law. However, many worry that this growth of supervisory organs is illegitimate. Consider, for instance• The European Court of Human Rights (ECtHR) is overburdened.• The human rights organs may disagree e.g. on how to balance freedom of expression against protection from hate speech. Which should be obeyed?• Citizens of well-functioning democracies ask: why should such international organs intervene?The MultiRights team of international lawyers and political theorists will first scrutinize the claims of legitimacy deficits. We then consider reform proposals for global and European human rights organs: We develop four plausible models, ranging from Primacy of National Courts to a World Court of Human Rights. We will assess the models by four Contested Constitutional Principles of legitimacy, revised for our multilevel legal order: Human Rights values, the Rule of Law, Subsidiarity, and Democracy.MultiRights thereby provides reasoned comparative assessment of models for human rights regime reforms, and contributes to better standards of legitimacy for international institutions. The findings also help us understand and assess the alleged ‘Constitutionalisation of International Law” - an urgent topic under globalization, when governance beyond states increases in density and impact.The academic contributions of MultiRights will also benefit several reforms:• the Interlaken Process on how to improve the ECtHR,• the accession of the EU to the European Convention on Human Rights under the Lisbon Treaty,• the UN Secretary General’s calls to reform the Human Rights treaty body system, and• challenges to the democratic credentials of such human rights review.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular Sensors and Dosimeters for the Optical Detection of Ions and Molecules' (OPTIDETIM).

assistant: **Concept**

The present research project is aimed to the design of molecular devices suitable for the optical detection of electrically charged and neutral guests. In particular, we intend to prepare dual responsive sensing devices, which are able to communicate to the outside, the occurrence of the recognition event through two distinct and independent channels:(i) colour change and(ii) modification of the fluorescence emission. This goal will be achieved by using as a signalling subunit a molecular fragment, which are both a chromospheres and a fluorophore. This dual responsive feature will be especially useful for the real space and the real time determination of analyses in systems like the whole cell and tissues, when investigated by optical co focal microscopy. Sensing devices will be designed for the following classes of analyses: metal ions, anions, amino acids, and small molecules like NO and CO. Two distinct paradigms will be followed for the design of the molecular sensor:(i) the covalent linking approach (the receptor moiety and the signalling subunit are covalently linked together, either directly or through a spacer);(ii) the chemo sensing ensemble approach, which involves the weak and reversible interaction of the receptor with an optical indicator, to be displaced by the desired analyse. Either approach will be used depending upon the nature of the substrate. For the detection of transition metal ions, multidentate legends will be used as receptors. The nature of the chelating subunit, whether open or cyclic, will define the type of sensing device: with an open-chain receptor, metal binding will occur in a fully reversible way, thus giving rise to a sensor, if the receptor is cyclic, the metal will be included irreversibly into the macro cyclic cavity, thus producin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Syndromic approach to Neglected Infectious Diseases (NID) at primary health care level: an international collaboration on integrated diagnostic-treatment platforms' to be submitted under Seventh Framework.

assistant: **Abstract**

Neglected Infectious Diseases (NID) such as trypanosomiasis, leishmaniasis, schistosomiasis and soil-transmitted helminthiasis receive less than 5% of the global investment for tropical diseases research. Clinical praxis in disease-endemic countries (DEC) is rarely evidence based and does not make use of the latest innovations in diagnostic technology. NID–related research on diagnostics is particularly underfunded, and diagnostic tools are lacking for a number of NID.The aim of this proposal is to bridge the gap between existing technological innovation in diagnostics and clinical care practice for NID in resource-poor settings. The specific objectives are to develop simple, cost-effective diagnosis-treatment algorithms for three NID-related clinical syndromes: the persistent fever, the neurological and the digestive syndromes. Evidence-based algorithms for the primary care level will be designed with a patient-centred approach, following guidance from DEC stakeholders and making the best possible use of existing assays and treatments. Relevant diagnostic technology and diagnostic platforms will be introduced according to the specific epidemiological contexts in Africa and South-Asia.The research consortium brings together a network of clinical epidemiologists, a diagnostics development group, several partners from academia and SMEs. The consortium further includes workpackages on reference laboratory, economic evaluation, quality assurance and translation to policy.By developing accurate and affordable diagnostic platforms and by optimizing diagnostic-treatment algorithms, this project will rationalise treatment use, circumvent progression to severe presentations and thereby reduce NID morbidity/mortality and hinder the emergence of resistances. The project will resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Preclinical efficacy testing of hydrogen sulfide donors against diabetic complications' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Diabetic complications are the leading cause of morbidity and mortality in diabetic patients. Oxidative stress and inflammation contributes to the loss of endothelial function and dysfunction of the vascular endothelium plays a major role in diabetic macrovascular and microvascular complications. We found that hydrogen sulfide can reduce the hyperglycemia-induced mitochondrial reactive oxygen species (ROS) production in endothelial cells and can prevent diabetic vascular dysfunction in aortic rings. However, it has not been possible to test the protective effect of hydrogen sulfide against long-term diabetic complications because of its short half-life.Novel slow-release hydrogen sulfide donors were generated that allow long-term hydrogen sulfide treatment.  We now propose to test the protective effect of slow-release hydrogen sulfide donors against glucose-induced ROS generation and the development of diabetic long-term complications. We aim (1) to identify the most potent hydrogen sulfide donor compounds against hyperglycemia-induced ROS generation in endothelial cells (2) to test the efficacy of the lead compounds in human microvessels and (3) determine the efficacy of the most potent drug candidates against diabetic nephropathy in streptozotocin-induced diabetes (Type 1 diabetes model) and in db/db mice (Type 2 diabetes model).The mechanism of action of hydrogen sulfide against mitochondrial ROS generation suggests that slow-release hydrogen sulfide donors may be applicable against diabetic complications in humans. We expect that the proposed preclinical efficacy studies will initiate rapid clinical translation and these promising drugs will be used in human diabetic complications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Synthesis of Homochiral Metal Organic Frameworks (HMOFs) Using Schiff-base Derivatives of Amino Acids: Use of HMOFs in Asymmetric Catalysis, Chiral Separation, and Gas Storage'.

assistant: **Innovation**

The proposed research is aimed on syntheses of homochiral metal organic frameworks (HMOFs) and their functional uses in asymmetric catalysis, chiral separation, and gas storage. The Schiff-base linkers will be used together with a range of metal ions (alkaline earth metals, transition metals and lanthanides) for the synthesis of HMOFs.  The chirally pure amino acids will be coupled with different aldehydes in order to synthesize a variety of organic Schiff-base linkers.  Three different amino acids (alanine, serine, and threonine) and four precursor aldehydes (terephthalaldehyde, pyridine-4-carboxaldehyde, 4-(4-pyridinyl)benzaldehyde, and 5-(4-formylphenyl)pyrimidine) are chosen for synthesis of 12 such different linkers. Different chirality of amino acids will broaden the choice of the ligands further. The ligands with chirally pure amino acids will add chiral pockets at the channels of the synthesized MOFs. Besides the presence of metal ions which act as Lewis-acid sites, the MOFs will be rich of Lewis-base sites due to the presence of the imino groups of the Schiff-base linkers. Based on this, the MOFs will be used as asymmetric heterogeneous catalyst for different Lewis-acid and Lewis-base catalyzed organic reactions.  Besides this, the derived MOFs will be used as bifunctional catalysts. This is a new approach of using MOFs for both kinds of catalytic reactions, and will be studied for the first time. Individual Lewis-acid and Lewis-base catalyzed reactions, as well as concerted (both Lewis-acid and Lewis-base catalyzed) reactions will be studied. The derived MOFs will be also studied for chiral separation of small molecules and gas storage properties (Hydrogen and Methane). Due to the presence of the imino groups in the MOFs, they are expected to show good affinit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Forbush decrease model for expanding CMEs affecting Earth and Mars' (ForbMod).

assistant: **Innovation**

Solar storms, also known as coronal mass ejections (CMEs), are the strongest drivers of space weather. During planetary impacts, they cause short term decreases in the galactic cosmic ray (GCR) flux, called Forbush decreases (FDs). These depressions are observed in the interplanetary space, at the surface of the Earth and recently also on the Mars’ surface by the Curiosity Rover. A large subset of FDs is caused by interplanetary flux ropes (FRs), which expand during their propagation based on observational studies.Our main goal is to develop and test a new diffusion/expansion FD model which will be able to predict FD amplitude and time-profile caused by the FR passage at a given point in the inner solar system (< 2 AU). The model will be based on the widely accepted approach of the initially empty FR which fills up slowly with particles by perpendicular diffusion, but will be supplemented with the additional mechanism-expansion. The model results will be evaluated using appropriate spacecraft and ground-based measurements at Earth and by the Mars Curiosity Rover. This modeling and multi-spacecraft observational approach will allow testing unanswered hypotheses on the FD properties.The proposed research will be carried out in a 24-months project at the University of Graz, Austria, with secondments at the Space Research Institute of the Austrian Academy of Science in Graz, and at the Department of Extraterrestrial physics at Christian-Albrechts University in Kiel. These institutions are well recognized in the field of CMEs, FR modeling and GCR detectors and offer outstanding expertise and infrastructure needed for the implementation of the project. The project will generate new knowledge on the properties of cosmic ray decreases by solar storms, which is relevant for spac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CANITEST: Proof-Of-Concept of a PCR test designed to identify the dogs carrying the more virulent strains of Capnocytophaga canimorsus' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The idea to be taken as proof of concept is drawn from the ERC Advanced grant N°293605-CAPCAN (2012-2016). This grant aimed at understanding the molecular and genetic bases of the dramatic human infections caused by Capnocytophaga canimorsus. One of the questions that we addressed in the frame of CAPCAN is why are there so few cases of human infections while so many dogs carry C. canimorsus?  In other words, are all C. canimorsus strains equally dangerous and, if not, could we prevent the disease by detecting the dogs carrying the more dangerous strains?  During CAPCAN, among others, we showed that C. canimorsus is endowed with a capsular polysaccharide (CPS) and its assembly pathway was characterized [1]. We also showed that the CPS of 25/25 strains isolated from human infections present a limited variability, with 3 dominant capsular serovars. In contrast, only 4 out of 52 C. canimorsus isolated from dog mouths did belong to these three serovars [2]. This implies that a small minority of dog-hosted C. canimorsus strains are virulent for humans than most strains and that these strains can be identified by capsular serotyping.  We also set up a PCR test to achieve this capsular serotyping [2].  The proposal to be taken to proof of concept is to market the PCR test designed to identify the dogs carrying the more virulent strains of C. canimorsus.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Intellectual Heritage of Feminist Political Thought during Early State Socialism. The Cases of the GDR, Hungary and Yugoslavia' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project will be the first comparative and transnational intellectual history of feminist thought and women’s rights discourses in three East Central European countries: the German Democratic Republic (GDR), Hungary, and Yugoslavia from 1945 until 1956, the early years of de-Stalinisation. Drawing on a wide range of sources in four languages, and integrating the voices of women from ethnic and sexual minorities, this innovative project will trace the circulation and transfer of feminist ideas in the region during the crucial period of ‘building socialism’, when communist regimes were implementing radical policies to achieve the emancipation of women. This project reinterprets the story of feminism in the region in relation to state socialism and the history of state socialism through the lens of feminism. It also refines and challenges both the notion that women’s equality was fulfilled by state socialism and that there was no feminism behind the “Iron Curtain.” Socialist regimes claimed to have solved the ‘women’s question’ and dismissed feminism as outdated and unnecessary. But this project argues that feminist ideas informed a variety of intellectual and political discourses after 1945, including both official discourses of women’s rights, and more critical perspectives on questions such as the limits of political participation, reproductive rights, the uneven and highly gendered division of domestic work and even violence against women. This project will reconstruct the multiplicity of official and unofficial feminist discourses circulating in East Central Europe even during the period of Stalinism. By situating the broad variety of sources in their local, regional and transnational contexts, this project integrates feminist political thought and women’s rights
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated Research Infrastructure in the Social Sciences' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Principal characteristics of the facility and of the support offered to users: CEPS/INSTEAD (C/I) is a unique European socio-economic research installation a.,d network which develops and runs innovative national and international comparative micro-databases It is not only a data archive with well documented anonymised original microdata files from many countries, but also a data producer (Luxembourg Household and Firm Panel) and a comparability producer, with multinational/multilingual staff experienced in survey and panel methodology. The most important (and unique) international comparative microdatabases at CEPS/INSTEAD are rat the basic level of surveys: the Luxembourg Income Study and the Luxembourg Employment Study, and rat the more complex level of longitudinal studies a comparative database integrating national household panels in East and West (PACO-H), as well as a still experimental counterpart on firms and businesses (PACO-F). In the frame of a LSF Programme at C/I, visiting researchers would be selected and supported by experienced senior | researchers from C/l and partner institutions to do comparative work on its documented micro-databases The Centre offers opportunities to work in/on the following fields/issues in a comparative and interdisciplinary approach which focuses on similarities differences and interactive processes across space and over time - panel/survey methodology; - income dynamics; - persistent and new poverty; - child well-being/poverty, child care; - intergenerational relations; - effects of family and redistributive policies; - family structures and change; - household budgets; - geographical and social mobility; - gender, ethnic and social inequality; - education and training; - labour market/unemployment; - regional development and