RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The physics of flavor in visible and dark sectors' in the context of a Seventh Framework call.

assistant: **Objectives**

The topic of this proposal are two major open problems of high energy physics: the origin of flavor structure in the Standard Model and beyond, and the nature of Dark Matter (DM). We will (i) investigate the implications of flavor symmetries at future low energy machines and at CERN LHC, and (ii) develop a model independent description of direct DM searches and explore their relevance for astrophysical and collider signatures of DM. As part of the project we propose to implement General Minimal Flavor Violation in Minimal Superymmetric Standard Model (MSSM), calculate the renormalization group (RG) equations and discuss experimental consequences. We will explore how to extend the spurion analysis to the leptonic sector, e.g. for the description of deviations from tri-bimaximal neutrino mixing. In the course of the project we will also construct Effective Field Theory (EFT) operator basis for DM-nucleus scattering, and calculate the RG evolution. The Wilson coefficients will be constrained by fitting to the experimental data. We will perform matching calculations for representative DM models and show which representative DM models have LHC implications. The project will go well beyond the present 'state of the art' in the research field. As the end result of the first part of the project one may be able to describe consequences of supersymmetry breaking even when flavor symmetry is realized nonperturbatively. The second part of the project will lead to a much more efficient translation between experimental results and the theory space in DM models. For instance, after completion of this project in DM models with scalar exchanges only a tree level calculation will be needed instead of a 2-loop one in order to compare to data. In a few years, when the limits on DM scatteri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Generation of tumor neoantigens with photodynamic therapy: a new strategy for anticancer vaccines to fight head and neck cancer' (PDT-NEO-immunother), addressing dissemination and exploitation.

assistant: **Impact**

Immunogenic cell death (ICD) is a regulated cell death that stimulates the immune responses resulting in the establishment of long- term immunological memory. ICD alert the immune system by tumor-associated antigens and tumor neoantigens (i.e., antigenicity) and releasing immunostimulant mediators such as the damage- associated molecular patterns (DAMPs, adjuvanticity). ICD can be efficiently induced by photodynamic therapy (PDT). Our key hypothesis is that PDT based on clinically approved and in-house developed photosensitizers, which are efficient in several murine cancer models, will induce ICD in head and neck squamous cell carcinomas (HNSCCs) which are the fourth most frequent types of cancer in men. Specifically, we aim to demonstrate for the first time that PDT will modulate the immunogenicity of dying HNSCC cells not only by releasing DAMPs but also by increasing antigenicity of dying HNSCC cells by affecting their landscape of antigens. This will lead to the activation of the innate and adaptive immune system and to the improvement of anti-cancer therapy of HNSCC patients. For the study, we will exploit HNSCC cells derived from patients’ biopsies, representing an ideal preclinical model that incorporates heterogeneity of tumors observed in patients. In this way, we will obtain the data required to support future clinical trials based on PDT. Indeed, the ultimate goal of the neoantigen identification is to pave the way for developing patient-specific targeted vaccine therapies.


**Keywords:** Photodynamic therapy,  neoantigens,  head and neck cancer,  immunogenic cell death,  anticancer therapy,  ex vivo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Satellites and nuclear information. Production, communication and reception of nuclear-related information generated with satellites.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In our societies in which information is ubiquitous, satellites are still a matter of national pride and prestige, but they are also scientific laboratories, commercial projects, services’ providers, and part of global information infrastructures. Satellites are part and parcel of knowledge society.  In particular, satellite images and calibrated measurements contribute to generate technical information about nuclear accidents, as well as to convey the public perception of them, forge debates on nuclear energy, its management and its risks, and shape environmental, regulatory and political action. Satellite data are both resources that enable regulators and policy-makers to act during and after nuclear crises as well as instruments to communicate with the large public.  But how policy guidance is carried out to manage nuclear situations and how public perception of nuclear risks is constructed from, through and with satellite data?  By focusing on the information generated and consumed in the aftermath of two nuclear accidents (Chernobyl 1986 and Fukushima 2011), this project aims to explore in detail the processes that transform satellite raw data into knowledge, allowing us to understand how satellite information is produced, analysed, rendered evident, disseminated and consumed. Such historically informed comparative study will provide understanding of the historical evolution of the production, circulation and reception of satellite data and their actual impact in the contexts of both defining political action and framing public opinion related to nuclear issues. This innovative study will not only enhance our academic understanding of space, nuclear and information history (and their connections), but also alert us to how knowledge from space is generated as it is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving the quality of therapy in haemodialysis treatment test' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Freesias Medical Care (FMC) is the world's leading provider of dialysis products and dialysis care, with a total annual turnover of about euro Mio 4,269. The company treats more than 90,000 patients with chronic kidney failure in more than 1,200 clinics worldwide. FMC was created in September 1996 through the combination of the former Dialysis Systems Division of Freesias AG and National Medical Care Inc. Own research facilities at our R&D Divisions at Freesias Medical Care Deutschland GmbH at Bad Homburg (15 km north of Frankfurt Main) and the Schweinfurt production plant (close to Wartburg) with complete application laboratories and equipment enable effective and ongoing development and improvement of FMC's products and services. We continue to put emphasis on research and development to provide new generations of high quality products for haemodialysis and peritoneal dialysis online with the specific needs of the individual patient and the therapy approach. Scientific symposia, congresses and training courses are an essential part of our overall training and education activities. Under the Marie Curie training scheme FMC is offering four post-doctoral positions to work on the further development and improvement of dialysis treatment:(1) Water treatment devices for dialysis,(2) Cardiovascular stability in haemodialysis,(3) Anticoagulation,(4) Potassium Management. Candidates will work on different aspects of these subjects. They will have the chance to work in an exciting field of research and development in an open, interdisciplinary and international atmosphere, and acquire direct experience about the industrial context of this business. Fellows should have a degree in natural or medical sciences, preferably knowledge in physiology. In addition to the academic quali
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Packaging with AI for Circular Economy - strengthening Digimind's market position', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Packaging is the biggest contributors to the global waste problem because it is not designed for circularity. Given the changes in the legislations and the increasing customer awareness the packaging industry is under pressure to solve this problem at the design phase of their products. One of the main difficulties is to manage the trade-off of cost, performance and sustainability criteria, which leads to package performance uncertainties.  In this context, Digimind was created with the mission of accelerating the transition to circularity by dePackaging waste is one of the biggest contributors to the global waste problem, especially plastic packaging accounts for almost half the global plastic waste. Packaging design is driven mainly by marketing requirements, not incorporating any circularity, such as recyclability or reusability. With nowadays pressure due to limited material resources as well as the need to reduce CO2 emissions, circularity in packaging design becomes the new key driver. For the packaging industry this poses immense challenges to manage the new complexity of the trade-off of cost, performance and sustainability criteria. Digimind is developing an innovative software solution specifically for the packaging industry to tackle these challenges using digitalization and artificial intelligence.PACE objective is to strengthen Digimind’s position to successfully raise funding for the next phase of growth. The workplan to achieve this goal is twofold:  Setting up a technical use case with a glass packaging proving Digimind’s technology on a second material as well as improving our business plan and pitch deck. This consolidation of Digimind’s position in the market will allow me to raise money to lead the company to its next steps in delivering its unique v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Characterising the molecular and cellular basis of enteric nervous system alterations in the inflamed gut' (NeurogENSity).

assistant: **Concept**

Inflammatory Bowel Disease (IBD) encompasses two gastrointestinal conditions - Crohn’s disease and ulcerative colitis - which currently lack satisfactory treatment. IBD is associated with alterations to the enteric nervous system (ENS) of the gut, including the formation of new neurons (‘neurogenesis’) and changes in the properties of existing neurons (‘neuroplasticity’). Growing evidence suggests an interplay between acute inflammation and ENS pathology. Despite this, detailed characterisation of ENS alterations, their underlying molecular mechanisms, and how inflammation may induce them during IBD, is not well understood. The Marklund laboratory has recently uncovered a stepwise diversification model of enteric neurogenesis, suggesting that during embryonic development, subtype identities are specified through identity conversions in post-mitotic neurons. This work leads to the intriguing possibility that the identity of terminally-differentiated enteric neurons may, in fact, be flexible. However, whether stepwise diversification is present during adult inflammation-induced neurogenesis, and whether neuronal identity can be altered by extrinsic stimuli such as inflammation, remains to be assessed. Using a colitis model of IBD, single cell RNA sequencing of ENS and immune cells and spatial transcriptomics, NeurogENSity will characterise the composition of the inflamed ENS, revealing the cellular changes occurring as a result of acute inflammation. Pseudotime trajectory analysis, in combination with lineage tracing experiments, will address the nature of adult enteric neuronal identity specification. ENS-immune interactions which may underlie neurogenic and neuroplastic alterations will be identified, and their relevance assessed using cell depletion assays. Together, N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding the dynamics of cell divisioneuropean network for composite reinforcement' (EN-CORE) under Sixth Framework.

assistant: **Objectives**

Construction is facing its first major revolution in the use of new materials since the introduction of Reinforced Concrete (RC) more than a century ago. Advanced composites in the form of Fibre Reinforced Polymers (FRP) have been adopted in most strengthe ning applications and are being progressively used as reinforcement in new structures. The market for FRP in construction is expected to increase between 5 and 7 times in the next decade. This will lead to more durable structures and give a boost to the ai ling composites industry, an industry that is struggling to recover in the post cold war era and is in desperate need for diversification. Though research on FRP currently dominates the field of structural engineering much of this research is u ncoordinated and mostly fails to address fundamental scientific issues in any substantial depth. Moreover, despite the fact that a first generation of design guidelines has been produced, these are conservative and, in certain applications, undermine the u se of composites. Standard tests for defining the short and long term properties of FRP in RC are yet not available. The main aims of the project are to address specific scientific challenges in the field and develop tests and models to help wi th the standardisation process and to bridge the gap between academia and industry so as to accelerate the transfer of knowledge and adoption of FRP in construction. The network comprises a cohesive and complementary team of top experts in the field from 9 different countries. The network aims to create the ideal environment for delivering the best training for young researchers in the field of FRP reinforcement using a variety of delivery modalities, including an Intensive research training co urse, Young Researchers Conferences and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The subjective effects of oppression: Anna Julia Cooper and Black Existentialism' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

By going back to Anna Julia Cooper — an important though understudied figure of the end of the 19th and the beginning of the 20th centuries —, the present project draws on my doctoral research in critical phenomenology of lived oppression and applies it to the analysis of the transatlantic constitution of Black existentialism. The importance of issues related to intersectionality within existing feminist movements led me to question the history and conditions of emergence of these issues; it made a decentering necessary in order to illuminate the present from another geographic space (the United States) and according to a longer history. By tracing the genealogy of intersectional thought, I wish to make feminist thought more complex from its margins, and from a philosophical perspective (Black existentialism) in which women's figures are still under-represented.


**Keywords:** Feminist philosophy,  philosophy of race,  Black Feminism,  African-American History,  oppression,  subjectivity,  oppression
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NOVEL SYNTHESIS OF BIODEGRADABLE ALIPHATIC POLYESTERS FOR PACKAGING AND BIOMEDICAL APPLICATIONS' (DIBOP), addressing dissemination and exploitation.

assistant: **Impact**

Worldwide, the problems associated with the production of large amounts of waste are recognised as some of the most serious to be faced currently. For example, 41% of 30.4 million tonne pa of plastics used in the EU are used for packaging, more than 75% en ds up in landfill. In the case of plastic waste the preferred solution, up to now, is recycling. Nevertheless, degradable materials can play an important role to reduce these waste disposal problems. Biodegradable polymers, such as poly(lactic acid), not a ble to replace environmentally unfriendly packaging because their physical properties are representative of brittle materials. The work contained in this programme is designed to address this problem by producing plasticizers, that are also biodegradable, that can be blended with PLA and extruded to produce flexible films. A recent project supported by the EU under the CRAFT programme have shown that such plasticizers can be engineered from block copolymers of poly(ethylene glycol), a flexible block, and po ly(lactic acid), compatible with the base polymer.The main objective of this project is to continue the exploitation of our new method developed to replace the tin catalyst for the synthesis of poly(lactic acid) homopolymer and poly(lactic acid)-co-poly(et hylene glycol) (PLA-PEG) copolymers using a non toxic potassium based catalyst.The new catalyst system will also be used for the synthesis of other aliphatic polyesters such as poly(caprolactone), poly(glycolic acid) and their different copolymers.Using th is safe catalyst system, the obtained polymers can be directed towards different applications:- As modifiers for PLA to enhance its physical properties for production of environment-friendly packaging such as films, bottles, trays etc. - The combination of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Prevention of Liver Fibrosis and Cancer in Africa' (PROLIFICA), addressing dissemination and exploitation.

assistant: **Impact**

Chronic hepatitis B virus (HBV) infection affects 350 million people worldwide and 25-30% of these individuals will die as a result of their infection mainly as a results of hepatocellular carcinoma HCC. Liver cirrhosis, high viral load and dietary exposure to aflatoxin are recognised as risk factors for hepatocellular carcinoma amongst HBV carriers. However, these variables do not account for all cases of HCC and decompensated cirrhosis is rarely ever seen in West Africa suggesting that advanced liver fibrosis may not be an important risk factor in this population. A large case control study on HCC will be used to evaluate the importance of liver fibrosis and other established risk factors in West Africa and to explore other potential oncogenic determinants. The case-control study will generate serum, urine and DNA samples for proteomic, metabonomic and genomic analysis to identify biomarkers and aetiological agents for HCC.Effective treatment for HBV infection is now available in the developed world but treatment programmes have not been developed for resource poor settings even though some of the effective medication is now available at low cost for HIV management. A trial of HBV treatment in a group of carefully selected high risk patients will be conducted to demonstrate that the incidence of HCC can be reduced in this population as has been observed in Asian patients.  The treatment trial will also be used to evaluate the efficacy of screening by ultrasound for early tumours which can be treated with percutaneous alcohol injection.This comprehensive programme therefore aims to reveal novel aetiological factors for HCC, identify and evaluate biomarkers and demonstrate the efficacy of selective antiviral therapy to prevent HCC