RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Combating Multidrug-Resistant Gram-Negative Bacteria in Africa through Diagnostic and Antimicrobial Stewardship' (ComBac-Africa) targeting Horizon Europe.

assistant: **Abstract**

Antimicrobial resistance is a major global health threat for humans, animals and the environment, with the highest mortality and morbidity rates in sub-Saharan Africa (SSA). The World Health Organization prioritised several carbapenem- and third-generation cephalosporin-resistant Gram-negative bacteria such as Enterobacterales as the most critical pathogens with only very limited treatment options. Bacteraemia, sepsis and other severe infections caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB) give rise to excess mortality. Yet, the causative pathogens are rarely identified in patients in SSA due to a lack of microbiological diagnostics. Carbapenems and the new antibiotics ceftazidime-avibactam, cefiderocol and aztreonam-avibactam are active against different MDR GNB and could significantly reduce morbidity and mortality, but they are not widely available in SSA.The ComBac-Africa consortium has the overall goal to improve the management of severe infections due to MDR GNB in Côte d’Ivoire, Guinea-Bissau and Nigeria through the establishment of a needs-adapted diagnostic and antimicrobial stewardship (AMS) programme that provides equitable access to these novel antibiotics for targeted treatment. This will be achieved through (1) provision of high-quality and accurate microbiological diagnostics for prompt and correct identification of causative agents in bacteraemia and other severe infections; (2) a comprehensive One Health assessment of the epidemiology of GNB in humans, animal and environmental specimens; (3) tailored AMS initiatives, including early outbreak detection and infection prevention measures, to optimise the use of novel antimicrobials; (4) development of clinical algorithms for targeted diagnosis and treatment of infections due to MDR GNB;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Protein kinases in metabolic regulation in Mycobacterium tuberculosis' (STPKINTB) targeting Seventh Framework.

assistant: **Abstract**

The genome of Mycobacterium tuberculosis contains 11 serine threonine protein kinases. Amongst these PknA, PknB and PknG are essential for bacterial survival and/or virulence, and are considered potential drug targets. This proposal aims to elucidate the functions of PknB and PknG, with particular focus on the regulation of primary metabolism. PknB is reported to be involved in the control of cell-shape, whereas PknG might function as a regulator of metabolism or as a virulence protein secreted into the macrophage. Based on a study of the related microbe Corynebacterium glutamicum, preliminary work has been done to investigate a possible role for PknG (and possibly PknB) in regulation of the citric acid cycle. In corynebacteria PknG controls the phosphorylation status of a small regulatory protein GarA, which directly inhibits the ODH complex. First experiments with mycobacteria suggest that this regulatory mechanism is probably conserved and may also be employed to regulate nitrogen metabolism in these organisms. An experimental strategy is proposed to investigate the regulation of kinase activity and determine the effects of kinase activity on carbon and nitrogen metabolism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Algebraic Formula Lower Bounds and Applications', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Does efficient verification imply efficient search? Can randomness provide massive speed-ups in computation? These are fundamental questions in theoretical computer science, known as P vs. NP and P vs. BPP respectively. Progress on these questions requires us to to show that certain computational problems are inherently intractable, i.e. do not admit efficient solutions. An important, and concrete, approach to such questions is to understand the complexity of algebraic problems such as the Determinant and the Permanent, in algebraic models of computation. The aim of this project is to tackle these questions head on.Recent results of the PI and his collaborators have made progress on these problems by resolving a three-decade old open question. These results show intractability for algebraic models of bounded depth, which is a step towards P vs. NP. As a consequence, they also imply the first sub-exponential time deterministic algorithms for the important Polynomial Identity Testing (PIT)  problem in these settings, which is progress towards P vs. BPP.However, this barely scratches the surface of what we want to achieve. The aim of this project is to push beyond these state-of-the-art results in many directions. The principal goal is to prove the first lower bounds for algebraic formulas, which would be a huge breakthrough. Further, we want to improve our recently obtained lower bounds in order to devise faster PIT algorithms. We also want to show lower bounds over finite fields, and to explore the applications of such work in related areas such as algebraic proof complexity and algorithm design. The recent results point out a new way of exploiting structural and algebraic techniques to prove lower bounds. The aim is to develop and systematically investigate these techni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Archaeomagnetic applications for the rescue of cultural heritage', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Young researchers will be trained to best practice standards in archaeomagnetic work and associated scientific disciplines. They will come from a variety of backgrounds (archaeology, geophysics, geology, physics etc.) and will be given individual training programmes including: Subject specific training appropriate to their background, the research task and laboratory specialisms, but including understanding processes of magnetization acquisition, field sampling on diverse archaeological sites, measurement and analysis, data storage and multi-disciplinary applications. Transferable skills training including experimental design, project planning, time management and written and oral communication with scientific colleagues and the general public. All young researchers will join established research groups and will work within multi-disciplinary, international teams, including a wide range of specialists. Regular Network workshops will allow visits to a variety of EU facilities. The network' s international nature will give opportunities to work outside their home country, in cooperation with scientists from throughout the EU .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DePICting the interior of active VOLCanoes to reduce volcanic hazards: application to the present unrest at Nevado del Ruiz (Colombia) - PICVOLC' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

More than 500 million people live within the range of volcanoes whose activity can have disastrous economic and environmental impact. Being able to infer changes in the magmatic system during volcanic unrest is important for improving hazard preparedness and forecast future eruptions. PICVOLC aims to overcome the limitations in the current approach in the modeling of volcanic unrest by developing a new, original methodology that integrates seismic, gravity, and deformation data with 3D numerical inversion to create a detailed representation of the source of volcanic unrest. The current volcanic unrest at Nevado del Ruiz volcano will be the case study used to implement, calibrate, and verify this original approach. In 1985, a lahar generated by a modest eruption of Ruiz completely destroyed the town of Armero, killing 25,000 people. PICVOLC involves the integration of fieldwork with Finite Element Methods modeling and joint numerical inversions of geodetic and geophysical data. PICVOLC´s multi-/interdisciplinary nature aims to better constrain the conceptual and numerical models of volcanic unrest and reduce the ambiguity in the identification of the location, depth, volume change, and nature of the source of unrest. The project involves national and international collaboration; it is academic but has also important implications for the monitoring and reduction of volcanic hazards at Ruiz. In particular, it will provide the following innovative products: (a) definition of the subsurface structures with a new map of Bouguer anomalies; (b) 3D FEM model of the volcano; (c) 3D Image of the source(s) of volcanic unrest from inversion of geodetic data; (d) training of graduate students and the staff of the local volcano observatory in numerical modeling.Finally, PICVOLC will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'How demographic changes shape intergenerational solidarity, well-being, and social integration: A multilinks framework'.

assistant: **Concept**

The objective of this project is to investigate how changing social contexts, from macro-societal to micro-interpersonal, affect social integration, well-being and intergenerational solidarity across different European nations. Debates on ageing societies predominantly focus on the circumstances of the old. Our approach builds from three key premises. First, ageing affects all age groups: the young, the middle-aged, and the old. Second, there are critical interdependencies between family generations and between men and women. Third, we must recognize and distinguish analytical levels: the individual, dyad (parent-child, partners), family, region, historical generation, and country. Building from these premises, we examine: (a) multiple linkages in families (e.g. transfers up and down family lineages, interdependencies between older and younger family members); (b) multiple linkages across time (measures at different points in time, at different points in the individual and family life course); (c) multiple linkages between, on the one hand, national and regional contexts (e.g. policy regimes, economic circumstances, normative climate, religiosity), and, on the other hand, individual behaviour, well-being and values. Throughout the project we will test, develop, and use methodological strategies that enable sound policy making. By identifying intergenerational care regimes (that is, combinations of child care provisions and provisions for the frail old) and their shortcomings, we will contribute to the substantive understanding of the risks of becoming socially isolated and/or lacking necessary supports. A consortium of eight partners organized in six teams will carry out the project. All partners are involved in the Gender and Generations Program, a system of nationally
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Macro-Risk Assessment and Stabilization Policies with NewEarly Warning Signals'.

assistant: **Concept**

RASTANEWS intends to enhance knowledge base, at both theoretical and an applied level, on many aspects of the future of macro-economic and monetary integration in Europe thus paving the way to a revised governance of the EMU, and the EU as a whole, in the wake of the debt crisis. We see three key issues about the working of the EU macro-economy  that deserve deeper investigation.  The first is the issue of incomplete and informationally inefficient financial markets, the Achille’s heel of the consensus DSGE models. The second, related issue, is the heterogeneity in expectations, which should play a fundamental role in explaining the behaviour of  asset prices. The third issue is the need to overcome the traditional dichotomy between Keynesian (short run) and neoclassical (long run) policy prescriptions. Taking these issues seriously has important implications for the conduct of EU monetary and fiscal policies and for EU governance system. In addition, to facilitate the timely identification of macro risks, we propose a new system of early warning indicators, to be implemented within the EMU surveillance mechanism. This proposal is consistent with our theoretical framework and is based on an empirical macro-finance approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Microneedle Integrated Responsive Approach for Cancer Localized Treatment Execution during Plasmonic Photothermal Multimodal Therapy' (MIRACLE).

assistant: **Concept**

Cancer remains a critical global health challenge, with millions of new cases and deaths reported annually. Traditional treatments like surgery, chemotherapy, and radiotherapy often fall short, causing systemic toxicity, severe side effects, and cancer recurrence, significantly impacting patients' quality of life. The MIRACLE project aims to revolutionize cancer treatment by developing an innovative microneedle (MN) patch for localized, multimodal cancer therapy. Herein, the multimodal therapy integrates plasmonic photothermal therapy (PPTT), where nanoparticles (NPs) are selectively heated by near-infrared (NIR) radiation to destroy cancer cells, with photodynamic therapy (PDT), which generates reactive oxygen species and chemotherapy involving NIR radiation-triggered drug release to enhance treatment efficacy. However, challenges like limited accumulation of agents at tumor sites, unwanted distribution in healthy organs, and leakage during delivery limit clinical translation. The MIRACLE project will address these challenges by developing a NIR-responsive MN patch integrated with PPTT-assisted multimodal cancer therapy specifically designed for treating superficial cancers like melanoma. These MN patches, with micron-sized needles, painlessly penetrate the skins outer layer to deliver therapeutic agents directly to the tumor, ensuring localized delivery and release. Upon skin insertion and NIR irradiation, the MN patch will deliver NPs (for PPTT), a photosensitizer (for PDT), and a chemotherapeutic drug, concentrating treatment at the tumor, reducing systemic exposure and minimizing side effects. The project will validate the MN patch through in vitro, ex vivo, and in vivo studies. MIRACLE project aligns with the EU Mission: Cancers goals of advancing cancer treatment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'PROGRAMMED ACCELERATION OF EVOLUTION OF THE BIODEGRADATIVE GENE INVENTORY'.

assistant: **Objectives**

Evolution of the ability of microorganisms to degrade xenobiotic compounds, including many environmental pollutants, is slow and limited by a whole set of physiological and regulatory bottlenecks. This Project aims at harnessing natural mechanisms of generation of diversity and selection to accelerate in vivo evolution of the bacterial biodegradative gene inventory and to understand how they function in relation to the genomes of the strains bearing the enzymatic activities. Specifically, we propose to develop auto-evolving bacterial strains designed to rapidly activate a massive mutagenesis program on the molecular bottlenecks for biodegradation of target aromatics as soon as they face a given non-degradable compound. The workplan includes [i] reconstruction of ancestral catabolic enzymes to be included in an expanded biodegradative gene inventory [ii] in vivo selection for the best assembly of ancestral biodegradative genes with the potential to deal with recalcitrant compounds or mixtures thereof and [iii] a mutagenesis phase engineered to be triggered upon induction by an external signal. The result of these steps is the generation/selection of novel catabolic pathways towards an otherwise non-degradable compound. The proof of concept will involve the catabolism of test recalcitrant compounds (e.g. chloroaromatic pollutants) by bacteria endowed with a rapid evolving capacity in chemostats. This Project which builds on sound Synthetic Biology approaches will provide a proof-of-principle of a general approach to evolutionary engineering. The frame has potential impact in both environmental clean-up and the production of high-added value compounds. We argue that PROACTIVE and the technologies that are expected to emerge from it, can make a difference in the way new rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innate immune responses to human hepatotropic viral infections' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Chronic hepatotropic infections including hepatitis B (HBV) and C (HCV) are a major public healthconcern. Even though both viruses belong to completely distinct families the pathogenesis they elicit isstrikingly similar, leading to liver fibrosis and cirrhosis. Treatment for HBV and HCV consists of eitherdirect-acting antivirals or pegylated interferon (IFN)α. In contrast to HCV, these treatment regimen are noncurativefor HBV. Little is known to date about the host/pathogen interactions determining viral persistence.Both viruses are sensitive to IFN, activating the JAK/STAT signalling pathway to activate interferonstimulatedgene expression (ISG), which are ultimately acting as antiviral immune effectors. Nevertheless,neither type I or III IFN are very effective in their treatment.Here, we suggest investigating the mechanistic details of type I and type III IFN action on HCV andHBV in vitro and vivo with the goal of uncovering not only the differential ISG induction but furthermorecharacterise viral immune evasion strategies. Building on our previous success in dissecting the hostresponse to HCV and creating the first immunocompetent mouse model for HCV we aim at using both,novel microfluidic culture systems based on 3D hepatocyte cultures susceptible to both HCV and HBV aswell as human liver-chimeric mice in combination with single-cell analysis of the antiviral response againstHBV and HCV elicited by type I and III IFN. Additionally, we will utilize lentiviral high throughputscreening used previously for HCV to identify interferon effector molecules active against HBV. This projectwill not only provide new insights into the innate immune response to chronic hepatotropic virus infectionsbut furthermore holds the potential of uncovering novel drug targets, aiding in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Focused Ultrasound Personalized Therapy for the Treatment of Depression (UPSIDE)' under Horizon Europe.

assistant: **Concept**

Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting 300 million people with a lifetime prevalence of 15%. Approximately one third of all MDD patients fail to respond to currently established treatments based on medication and psychotherapy, thus falling into the category of Treatment-Resistant Depression (TRD) patients. Electroconvulsive therapy (ECT), repetitive Transcranial Magnetic Stimulation (tRMS), Vagus nerve stimulation,  deep brain stimulation (DBS) and transcranial focused ultrasound (tFUS) still show poor spatial resolution (ECT, tRMS, tFUS) or low network coverage (VNS, DBS), with average remission rates in clinical trials still lower than 30 %. Apart from the existing stimulation hurdles, reliable biomarkers for depression are needed as a diagnostic tool, and, in the case of NT, to determine the stimulation efficacy and allow for personalized treatment. The UPSIDE project proposes a minimally invasive, high spatial resolution and multi-brain region stimulation and recording system to largely exceed the capabilities of existing NT for depression. Our objective is to research and validate in vivo an hybrid neurotechnology consisting of an epidural focused ultrasound (eFUS) stimulator employing three-dimensional beamforming, and a high-density epidural EEG recording system. Epidural deployment of these devices will be enabled by novel methods for massive integration and miniaturization of high-performing piezoelectric ultrasound materials and high-fidelity organic bioelectronic materials with high energy-efficient complementary metal-oxide semiconductor (CMOS) technology in a biocompatible manner.  The UPSIDE project will result in a demonstrator which will allow, for the first time, network stimulation and simultaneous biom