RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Crashworthiness of aircraft for high velocity impact (CRAHVI)' (CRAHVI), addressing dissemination and exploitation.

assistant: **Impact**

The Overall objective of CRAHVI is to develop methods and tools to predict the behaviour of aircraft structures subjected to high velocity impacts. Implementation of such methods will promote enhanced safety through damage tolerant aircraft design and the development of crashworthy aircraft concepts. The impact scenarios considered in CRAHVI are bird strike on leading edge structures, debris hits (tyre and engine debris on access panel and front spar, respectively), hailstone on composite structure and fuselage impacts on water, soft soil, slopes and flight into obstacles. FE methods will be developed to predict the response of aircraft structure subjected to these impact scenarios. In order to develop the FE methods, models for material, joints, surfaces, impactors are required to be incorporated into the FE simulations. In conjunction with the FE simulation results, stochastic methods will be applied to the impact and crash simulation of aeronautical structures. Local/global and FE methods will be developed to determine the loading on several generic aircraft under realistic crash conditions such as impact on different surfaces, rigid, soft soil, and water with different sea states. This will provide a load database for the cabin environment which can be used for the design of innovative cabin safety features with the aim to improve passenger safety.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced Solid State Transformers' (ASSTRA), addressing dissemination and exploitation.

assistant: **Impact**

ASSTRA is an interdisciplinary training and research project that targets the development of advanced solid state transformer technology which enables a sustainable and flexible (‘Smart’), DC-equipped energy supply system with a large share of renewable energy sources. This futuristic electrification network has in its core a flexible power conversion unit, distributing electrical energy from sources to loads in a similar fashion as today’s internet hubs distribute information from senders to receivers. Specifically, this power conversion unit integrates state-of-the-art technology, such as Silicon-Carbide, in order to implement power electronics building blocks and magnetic components featuring breaking through performances, which will ultimately enable its industrial deployment. ASSTRA involves a two-partner network comprising the Eindhoven University of Technology (TU/e) in the Netherlands and ABB Corporate Research Center in Switzerland as beneficiaries. These partners complement each other in order to cover the knowledge and expertise fields required for the proposed program. A board of 6 experienced supervisors will intensively work together across a multitude of disciplines, including power electronics engineering, mechanical engineering, software engineering, material sciences and magnetics design, to train and mentor 2 Early Stage Researchers who will have access to excellent research facilities and close coaching approaches at both locations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The emergence of Modern Hebrew as a case-study of linguistic discontinuity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The pioneering enterprise I propose is the study of a particular type of linguistic discontinuity –  language revival – inspired by the revival of Hebrew at the end of the 19th century. The historical and sociocultural dimensions the revival have been studied before, but not its linguistic dimensions. My main aim is to construct a model of the linguistic factors which have shaped the revival of Hebrew. I expect this model to provide clues for the understanding of the process of language revival in general. For a language to be revived, a new grammar must be created by its native speakers. I hypothesize that the new grammar is formed by some of the general principles which also govern other better known cases of linguistic discontinuity (creoles, mixed languages, emergent sign languages etc.). The model I will develop will lay the foundation for a new subfield within the study of discontinuity – the study of language revival. I will start with careful work of documenting the development of the grammar of Modern Hebrew, in particular its syntax, something which has not been done systematically before. One product of the project will be a linguistic application for the documentation and annotation of the novel syntactic constructions of Modern Hebrew, their sources in previous stages of Hebrew and in the languages with which Modern Hebrew was in contact at the time of the revival, and the development of these constructions since the beginning of the revival until the present time. The linguistic application will be made available on the web for other linguists to use and to contribute to. The institution of an expanding data-base of the syntactic innovations of Modern Hebrew which comprises both documentation/ annotation and theoretical modeling which could be applied to o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High speed and high torque electric transaxle enabling unprecedented use in agricultural applications' (TX3) under Horizon 2020.

assistant: **Objectives**

The world of agricultural equipment continues to evolve in order to adapt to the needs of the sector, shifting to the use of small and efficient electric vehicles (EVs), which are more suited for compact dimensions and high performance. Such is the requirement in farms, nurseries, greenhouses and vineyards, where movement space for vehicles is confined, the crop sensitive to green-house emissions and high towing capacity is necessary. The most important component to contribute to torque and speed is the transmission system (transaxle). Current transaxles fitted on electric vehicles are less efficient, have a cumbersome design, consume more electrical energy, have reduced battery operational time and are more expensive, thereby costing farmers up to 50% more in operational expenses. TX3 aims at realizing an efficient ""Third Generation Transmission Axle"" presenting flexibility in torque and speed and a compact design to suit the needs of the sector. We will combine the best technologies in mechanical gear ratios, mechanical differential locking and transaxle modularisation, to produce a novel design that will completely revolutionise transaxles for the agricultural electric vehicle sector. The high efficiency of the transmission will allow for enhanced vehicle autonomy with higher load capacity and longer battery life expectancy on a single charge. The application of TX3 is expected to have ripple benefits across Europe and globally, maximising the productive running time, thereby increasing productivity for farmers.We will utilize our well established commercialization channels, which include our presence in 40 countries across 5 continents, to break onto the international markets, starting with Italy, Germany and France.  In 2014, the agricultural machinery industry p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Efficient Energy Management for Greener Aviation' under Horizon 2020.

assistant: **Concept**

The trend towards More Electric Aircraft with higher integration of different sub-systems into a common energy network requires innovative approaches for the energy management. First, a well-designed energy management saves energy by optimizing power split. Second and more important, it allows by its improved handling of loads to reduce the conservatism of the architectural design and hence weight and emissions.Therefore, energy management functions are a key enabling technology that needs to be available in early architectural design. They shall be of limited complexity in order to be quickly developed and potentially certifiable for on-board implementation.The project Energize will create innovative model-based algorithms tailored to exactly meet these demands. The approach is based on the extensive model-base from DLR and NLR. From here, the vital non-linearities are concentrated into cost functions. The logic of supply and demand is then used to generate model-based algorithms for the energy management. This approach will provide a common solution for the electric and thermal domain while taking the domain-specific aspects into account.The maturity and industry acceptance of this proposal has been demonstrated by preceding research activities. Hence, bringing this methodology up to TRL5 in cooperation with the topic manager, will optimize the design of future aircraft and contribute to Flightpath 2050 goals. Energize’s exploitation plan will improve the competitiveness of the European aviation industry but also ensure that vital methodological know-how reaches the scientific community and other European industry sectors. In addition, the use of model-based assessment and algorithms within aviation shall be facilitated as long-term impact.The Energize consortium, con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Energy efficient, intensified spray drying' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objective of this proposal is the development of a well-tested, generic design procedure for spray drying facilities based on state of the art computational fluid dynamics (CFD) calculations with novel elements to describe agglomeration. The procedure will form the basis for spray facilities to be optimised in terms of more compact (intensified) plant, greater energy efficiency and higher product yield. The calculations will be evaluated by simultaneous spatially and temporally resolved measurements of size, velocity, flux and concentration of sprays, some of which will be obtained in industrial scale plant. A unique and innovative laser technique (shadow Doppler anemometer) appropriate to the irregularly-shaped particles - which cannot be sized with spatial precision in any other way - found in spray dryers will be used. The performance of this new instrument will be thoroughly established by reference to advanced calculations of light scattering. The industrial relevance and interest in the resulting design procedure is demonstrated and assured through project co-ordination by a major manufacturer of spray dryers and the results will benefit from the experience of another industrial partner which is a major end-user: both have extensive experience of measurements and are users of CFD packages. The specific objectives are: (i) to develop an innovative mathematical model of particle agglomeration; (ii) to incorporate (i) into a research, non-commercial CFD code; (iii) to evaluate the accuracy of an innovative instrument for the pointwise, time-resolved measurement of particle size and velocity of irregular particles using light scattering programs; (iv) to construct the instrument of (iii) and use it to measure in model and full-scale spray dryers; (v) to evaluate t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Comprehensive Translational Research and Training Pipeline Harnessing Lipid Metabolism to Improve Prostate Cancer Management and Educate Young Researchers in Tackling Complex Disease' in the context of a Horizon Europe call.

assistant: **Objectives**

PROSTAMET is an immersive Doctoral Network (DN), that aims to train the next generation of researchers tackling complex multifactorial diseases, including cancer, that are typically characterized by an outspoken inter- and intra-patient heterogeneity and that increasingly face our ageing society. Despite unprecedented technological advances to dissect disease into its smallest details, the translation into cost-effective and personalised treatment approaches is one of the timeliest challenges that face the scientific community and that require a specific transdisciplinary mindset and education. Focusing on prostate cancer as a key paradigm of such a complex disease and as one of European Health Union’s new focus areas for organised screening, PROSTAMET aims to bridge current gaps in translational research, capitalising on the underexplored clinical potential of altered lipid metabolism in cancer. Through a close collaboration among well-selected academic and non-academic partners with highly complementary expertise, PROSTAMET aims to set up a unique lipid-focused translational research pipeline from cutting-edge spatially-resolved molecular discovery, through validation in gold-standard models, all the way to innovative drug development. Through its modular and bidirectional nature with multiple entry points, this pipeline is expected to generate outputs at multiple levels of the drug development chain for sustainable downstream valorisation. Through a combination of high-level technological “hands-on” research, non-academic placements and courses/workshops on scientific and complementary “soft” skills facilitated by the academic/non-academic composition of the consortium, PROSTAMET’s ambition is to provide young researchers with a creative and holistic view on translat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Gene-edited T cells combating IgA Nephropathy. A blueprint approach for safe & efficient genome editing of T cells to sustainably combat several immune diseases and cancers related to B-cell pathology'.

assistant: **Innovation**

There is an increasing prevalence of chronic diseases caused by undesired immune reactions (>10%) with high burden for the both patients (chronicity, organ failure, early death, decreased QoL) and society (EU:>100 bn €/a direct health costs) as current therapies are limited in efficacy and do not reshape sustainably the disturbed immune balance. Our ultimative goal is to develop a safe and efficient cell therapy based on genome-edited T cells with redirected specificity to sustainably combat IgA nephropathy (IgAN) - the most common glomerulonephritis and one of the most common causes of end-stage renal disease with unmet medical need. Our specific cell therapy approach is also suitable for other diseases with selective B-cell pathogenesis, such as IgA myeloma, IgA related celiac disease and rheumatoid arthritis, but as a blueprint also for diseases of other Ig classes (e.g. IgG4).  Our novel concept offers a specific form of immunosuppression via Ig-(sub)class targeting & glycosylation targeting with redirected T cells in autoimmune diseases. Methodically, we benchmark three promising genome editing technologies, develop new standards for safety assessment and preclinical performance evaluation.   At the end we will have a lead candidate of a new ""living drug"" product envisioned as a one-time treatment for IgAN and other IgA-associated that will be ready to enter clinical FIH trials (entry into TRL6). In addition, geneTIGA delivers enabling technology toolboxes with exploitation options beyond of the core project. They might de-risk and accelerate the development of next-generation gene and cell products in general. The project has thus, besides its scientific value, a high impact not only on the affected patients with IgAN and related immune diseases, but also for th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Advanced hybrid theranostic nanoplatforms for an active drug delivery in the cancer treatment'.

assistant: **Objectives**

Cancer is one of the leading causes of death worldwide. Great efforts are still necessary to individuate new therapeutic strategies aimed to reduce cancer recurrence and to define new potential adjuvant targets for inhibiting invasion and metastasis, two significant contributors to death among patients. The combination therapy based on the simultaneous administration of two or more pharmacologically active agents with different modes of action using nanocarriers for the delivery could represent an effective strategy for the treatment. The increase in efficacy of a therapeutic formulation is causally related to its ability to selectively target diseased tissue, overcome biological barriers, and smartly respond to the disease environment to release therapeutic agents. The increasing interest in the employment of nanostructured materials to medicine-related branches is attributable to its unique properties allowing highly efficient drug delivery, molecular sensing applicable in diagnosis, multiplex imaging, or construction of point of care therapeutic devices. This project aims at an establishment of a consortium consisted of Regional centre of advanced technologies and materials (part of Palacký University), The Institute of Science and Technology for Ceramics (part of CNR) and Maynooth University which will through a set of workshops, seminars and extensive exchange of early-stage researchers develop an efficient scientific cluster. The research of the cluster will aim the development of functional 3D dual-modality nanostructures for targeted drug delivery and cell imaging.


**Keywords:** drug delivery, nanoplatforms, nanoparticles, cancer, drug development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'From the origin of Earth's volatiles to atmospheric oxygenation'.

assistant: **Innovation**

Aim of this project is to understand the connection between endogenic and exogenic processes of our planet that led to the redox contrast between Earth’s surface and interior. For this purpose the time constraints on atmospheric oxygenation can be refined and for the first time linked with a new approach to Earth’s endogenic processes like plate tectonics, mantle melting, volcanism, continent formation and subduction-related sediment- and crust recycling. These objectives will be achieved by using the unique geochemical capabilities of the selenium (Se) isotope system to unlock the geological record of changing oxygen fugacities in the mantle-crust-atmosphere reservoirs. The power of the Se isotope system lies in its redox sensitivity and in the volatile and highly siderophile/chalcophile character of elemental Se. This links Se to the evolution of other volatiles during key geological processes from Earth formation ca. 4.5 Ga ago until today. The occurrence and behavior of Se is fully controlled by accessory micrometric sulfide minerals in the silicate Earth, which may conserve their original Se isotopic signatures over large geological timescales and can be dated via the 187Re-187Os geochronometer. This offers high resolutions in time and space that are groundbreaking for research on Earth System Oxygenation. Covering Earth geologic history, new high-precision Se isotope data of the sedimentary and representative mantle-derived magmatic rock record from all major plate tectonic settings will be combined with the mineral-scale record of robust and global “time capsules” such as diamond inclusions. Once the evolution into todays dynamic Earth’s Redox System is understood, the investigation will be pushed back in time to Earth’s formation. This involves a reconciliation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Targeting the cancer stem cell (CSC) metabolism with designed, reactive metal complexes'.

assistant: **Concept**

Designed, bulky metal complexes with a labile coordination position react with accessible guanines at G4 DNA quadruplexes, promoting changes in their conformation and function. Importantly, we have found that this selective reactivity leads to very interesting biological effects. In particular, some of these compounds are able to suppress the “stem”-like character of cancer stem cells, apparently by deterring their mitochondrial respiration. Preliminary experiments, including in vivo assays, confirm that these biological effects result in remarkable antitumoral activities. This proposal aims to explore the scope of the approach, confirm that the mechanism of action involves mitochondria, design more selective versions and exploit the potential of the compounds as new type of anticancer agents.


**Keywords:** synthetic metal complexes, ruthenium, coordination chemistry, anticancer chemotherapy, cancer stem cells, chemical biology, biomedicine