RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Circular Construction In Regenerative Cities (CIRCuIT)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

To this day, many techniques, tools and approaches have been developed and tested either on a lab scale or in pilot buildings around Europe. These demonstrations have served as great showcases for circular built environments, but they are yet to be demonstrated at higher level.  Copenhagen, Hamburg, Helsinki region (City of Vantaa) and Greater London have teamed up with partners from the entire built environment value chain. The results will have a direct uptake in the value chain and enable cities to initiate circular transition. CIRCuIT will demonstrate three innovative solutions in the four cities: dismantle buildings to reuse materials; transformation and refurbishment; and design for disassembly and flexible construction.  CIRCuIT will develop urban planning instruments to support cities in implementing circular construction solutions and initiate changes at system level; implement a Circularity Hub, a data platform to evaluate progress of circular economy and regenerative capacity; and set up a knowledge sharing structure, the CIRCuIT Academy, to promote upscaling of solutions. London, Hamburg, Helsinki region and Copenhagen have the ambition to bridge the implementation gap from individual pilots to the actual circular and regenerative city, by demonstrating the application of current and future developed tools and instruments for circular built environment at a city level in 36 demonstration projects. It is the intention to boost the regenerative capacity of the three cities and Helsinki region, and finalise the development of an advanced set of indicators for impact measurement in an effective and cross-European monitoring programme. The aim is to increase the regenerative capacity in the four cities, and to reduce the yearly consumption of virgin raw material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cellular Position Tracking Using DNA Origami Barcodes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The research I propose here will provide an enabling technology; spatially resolved transcriptomics, to address important problems in cell- and developmental-biology, in particular: How are stem cells in the skin and gut proliferating without turning into cancers? How are differentiated cells related, in their transcriptome and spatial positions, to their progenitors?To investigate these problems on a molecular level and open up paths to find completely new spatiotemporal interdependencies in complex biological systems, I propose to use our newly developed DNA-origami strategy (Benson et al, Nature, 523 p. 441 (2015) ), combined with a combinatorial cloning technique, to build a new method for deep mRNA sequencing of tissue with single-cell resolution. These new types of origami are stable in physiological salt conditions and opens up their use in in-vivo applications.In DNA-origami we can control the exact spatial position of all nucleotides. By folding the scaffold to display sequences for hybridization of fluorophores conjugated to DNA, we can create optical nano-barcodes.  By using structures made out of DNA, the patterns of the optical barcodes will be readable both by imaging and by sequencing, thus enabling the creation of a mapping between cell locations in an organ and the mRNA expression of those cells.We will use the method to perform spatially resolved transcriptomics in small organs: the mouse hair follicle, and small intestine crypt, and also perform the procedure for multiple samples collected at different time points. This will enable a high-dimensional data analysis that most likely will expose previously unknown dependencies that would provide completely new knowledge about how these biological systems work. By studying these systems, we will uncover m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From Bulk to Edge: Realization and Characterization of Fractionalized Quantum Matter' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Most phases of matter can be understood using the concept of symmetry breaking. For example, the organization of water molecules in an ice crystal breaks the continuous translational symmetries that are preserved in liquid water. The discovery of the quantum Hall effect triggered a revolution of this concept. It was the first example of topological order, a type of order that cannot be detected with any local measurement and supports exciting new properties. A striking example is the universal transport properties which are so robust that metrologists use them to define the quantum of conductance. Additionally, exotic particles with fractionalized quantum numbers called anyons may emerge as collective excitations of these systems and could provide a route to fault-tolerant quantum computing. Despite the increasingly good theoretical understanding of fractionalized phases, there is a strong need to relate the theories to experimentally relevant models.sharpEDGE will build new bridges between the effective and microscopic descriptions of fractionalized phases of matter. This requires us to solve a cumbersome quantum many-body problem. Numerical methods are essential here: they have accompanied the progress of the field since its early days, and the most recent developments give hope to solve some long-standing issues. We will thus apply a multidisciplinary approach combining the latest advances in topological quantum field theory, quantum information, and material science. Fractionalization may occur in gapped systems such as the fractional quantum Hall effect, lattice topological insulators or frustrated magnets, but also in exotic metallic phases. In this context, we will explore the microscopic relation between the edge and the bulk of gapped topological phases, and de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Design and development of exosomes with brush type architecture as RNA delivery vectors for active targeting of blood brain barrier (BBB)'.

assistant: **Objectives**

MicroRNAs (miRs) are identified as significant regulators in modulating brain functions in central nervous system (CNS) disorders like Alzheimer’s disease (AD), Huntington’s and Parkinson’s disease (PD) and amyotropic lateral sclerosis. Sustained delivery of miRNAs to brain could be an excellent strategy to regulate gene expressions affected in the progressive neurodegenerative diseases. Highly biocompatible nanocarriers like extracellular vesicles (eg: exosomes) are an excellent choice as delivery vehicles for miRs but their short half life in systemic circulation and difficulty in crossing BBB limits the application. ExoBBB proposes to use high density polymer brushes to maximise RNA capture and stability, confer biofunctionality, stealth behaviour and active targeting to CNS. Density and chemical composition of these polymer brushes can be tuned precisely to attain optimum physicochemical features necessary for active targeting of BBB. Grafting of polymer brushes over exosomes can impart a star shaped architecture which in turn has been proven effective for neuronal targeting. In addition, these brushes can offer abundant surface functionalities for the conjugation of active targeting ligands. Dual targeting ability of the polymer brush chains will be evaluated by surface modification with peptides which can actively target BBB and neurons. The aim of ExoBBB is to design highly stable and efficient cationic polymer brush-based RNA delivery vectors that can be grafted on safe and biocompatible nanoparticles like exosomes for brain targeting and regulation of neuronal cell phenotype for prolonged periods of time.


**Keywords:** Exosomes, Polymer Chemistry, Blood Brain Barrier, miRNA therapy, neuronal disorders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Blueprint for Photonic Quantum Computer', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Recent technological advances allow to build revolutionary devices for information processing by making use of the laws of quantum mechanics. Most strikingly, quantum communication allows to transmit information with physical security guarantees at rates exceeding the capacities of classical links and quantum computers provide a means to speed up certain computations solving certain problems faster than any (present or future) classical computer. One such problem is factoring large numbers into their primes. This problem is the basis of much of modern cryptography such as the security of any information transfer through the internet. But the factoring problem was shown to be efficiently computable on a quantum computer using Shor’s algorithm. A functional quantum computer would therefore jeopardize the security of the internet. Quantum computation with a discrete-variable system such as a two-level electron spin demands temperatures colder than those found in deep space. However, continuous-variable systems, such as photons (particles of light) can operate at room temperatures and are more robust against decoherence, allowing for full miniaturization and mass manufacturing. The theory of quantum error-correcting codes provides a new set of techniques to run a quantum algorithm with an arbitrary level of accuracy despite using imperfect noisy photons. Photonic quantum codes exhibit either translational or rotational symmetry in phase space. Potential of the latter has remained largely unexplored despite convincing evidence for a striking advantage. In PhoQC, I will develop a novel stabilizer formalism to systematically study rotational symmetry in phase space. I will find quantum codes operating on the entire or a part of the Hilbert space and I develop the corresponding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An integrative genetic approach for the exploration of melanoma immunological interactions' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Immunotherapy, which has revolutionized cancer treatment, largely relies on the immune system’s recognition of neopeptides, degradation products of altered proteins specific to cancer cells presented on their surface. In particular, cancer vaccines targeting neopeptides have shown promising clinical results. Yet, to optimize their efficacy and broaden their application, we need to decipher the nature of the cancer peptide landscape (immunopeptidome) and delineate the neopeptide properties required to induce a potent immune response. The overarching goal of this proposal is to provide an unprecedented, thorough, multifaceted understanding of the mechanisms underlying aberrant peptide production, peptide-MHC presentation, and T-cell recognition in melanoma. We will do so by pursuing three key avenues: Systematic interrogation of the cancer immunopeptidome to identify novel canonical and non-canonical cancer antigens and quantify their presentation (Aim 1). Comprehensive functional assessment of the intrinsic qualities of actionable antigens by quantitatively charting the immunopeptidome in-vivo, while considering peptide presentation levels, clonality and cross-presentation; and delineating how these neoantigen qualities impact the immune response (Aim 2). Establish controlled in-vivo models to tease apart neoantigen qualities for the establishment of rational cancer vaccine modalities (Aim 3). In this effort, we will draw upon our pioneering tools and advanced mapping of the cancer peptidome in melanoma, which has already revealed novel antigenic sources. Our research approach combines comprehensive quantitative immunopeptidomics, novel imaging and computational approaches, advanced functional assays and novel mouse models. Our project will provide a fresh view of melano
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EnhAnced Government LEarning', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Public administrations (PA) need to cope with various challenges: new regulations, an aging workforce and the need for adopting their ICT. Technology-enhanced learning (TEL) represents thus a sensible option notably for rural local governments (RLG) that need to keep up with such changing environments, but do have limited ac-cess to training courses.From interviews of a pre-study with RLG in 5 European countries we know that obstacles are to include learning in the work process and a lack of training plans. There are deficiencies in communication and collaboration skills despite regular use of computer and mobile devices.EAGLE's main objective is to equip employees in RLG with a holistic training solution based on Open Educa-tional Resources (OER) and Open Source (OS) tools, supporting learning of critical transversal skills such as ICT literacy and professional management of change situations. EAGLE outcomes include an innovative change management model for a learning-enhanced work process, a proficiency-based cross-device OER curriculum, and contextualization tools for multilingual collaboration. These will be integrated in the novel EAGLE OER Open Learning platform that includes a new OER ontology for public administration and combines open data and learning platforms feeding into user services, argumentation technology tool and semantic search.Our solution will thus support OS business models for the benefit of technology and e-learning providers. It will be built on existing OS tools and frameworks, IEEE OER standards and the CKAN open data standards. The EAGLE consortium includes leaders in European OER, TEL, online assessment, mobile learning and e-government research as well as experts in organisational and pedagogical development, semantic web systems and servi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Large-grain thin-film crystalline si solar cells on ceramics (LATECS)' (LATECS) under Fifth Framework.

assistant: **Objectives**

Objectives and problems to be solved:The consortium, consisting of partners stemming from research and industry, wants to elaborate a cost-effective thin-film crystalline Si solar cell technology, based on thermally assisted Chemical Vapour Deposition (CVD) as deposition technique. The low-cost substrate to be developed further within this project is mullite, a ceramic consisting of Al2O3 and SiO2. The project wants to focus on the realisation of a solar device-worthy thin crystalline Si-film on this substrate by proposing a number of innovative approaches. These approaches avoid the complexity of processes in which zone melting recrystallisation is involved to increase the grain size. These innovative techniques have in common their ability to control and to increase the grain size of the film in which the active layer is produced. A previous European Project (SFINCS: JOR3-CT98-0233) has established the potential of mullite as a low-cost substrate for thin-film crystalline Si solar cells. Cost predictions indicate that its cost can be as low as 30-40 Euro/m2, which is the lowest amongst the substrate candidate materials at the moment. This substrate is also compatible with CVD to realise the active layer. The suitability of this substrate is further evidenced by the relatively high efficiencies obtained in solar cells on mullite (8-9% under AM1.5) in Si-layers recrystallised by Zone Melting Recrystallisation (ZMR), which did not suffer from cracks thanks to the good match between the thermal expansion coefficients of mullite and Si. In order to avoid the complexity of ZMR, this project proposal proposes to control and increase the grain size of the active film by an innovative approach.Description of the work:This approach aims at increasing the grain size by depositio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Precision Parton Distributions for New Physics Discoveries at the Large Hadron Collider' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

In the next few years very significant progress is expected in the understanding of fundamental interactions, due to information coming from experiments at the LHC collider at CERN. The LHC will pose an unprecedented challenge: to discover new physical phenomena using methods which have so far been used for precision studies of phenomena which are already known. This challenge requires a radical rethinking of the way one arrives at predictions for collider processes. There have been recent attempts at collecting all the available information on important LHC processes (such as Higgs, W or top production): these studies have invariably found  that theoretical and phenomenological uncertainties had been previously underestimated,  that the impact of QCD corrections is very significant, and that the dominant uncertainty  comes from ignorance of the structure of the nucleon. The goal of this project is to provide  such a rethinking, starting from the bottom up, i.e. starting from a new determination of the quark and gluon substructure of the nucleon, as encoded in parton distributions (PDFs). These new PDFs, the NNPDF sets, are obtained using a completely new approach, based on neural networks combined with a  Monte Carlo technique. This approach will provide not only a theoretically and phenomenologically reliable and consistent set of PDFs, but also a flexible tool which can be used to assess the impact of various theoretical ingredients (such as higher order  perturbative corrections and their resummation) and of the new  experimental  information obtained at the LHC. The corresponding studies will be the main result of this project: we will  be able to determine the combined impact of the wealth of theoretical and experimental  information which has been accumulating ov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Impact of ultraviolet radiation on health; Nutrition for systemic p rotection' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Ultraviolet light ( UV), present in sunlight and artificial sources (e.g., tanning equipment) has a negative impact on life. The most serious harmful effect is the induction of skin cancer. The incidence of non-melanoma skin cancer is increasing by 5% annually because of the increasing ultraviolet exposure caused by the popularity of sunny holidays and sunbed use. This increase is expected to accelerate further, since the depletion of atmospheric ozone is anticipated to increase by 10-15% the average level of ultraviolet-B (UVB) reaching the earth's surface. The mechanism underlying photocarcinogenesis is not completely elucidated. For accurate risk assessment of UV radiation on human health better understanding of the carcinogenic process is necessary. Therefore, events responsible for initiation (DNA damage formation, mutagenesis) and promotion (altered gene expression, immunomodulation) of skin cancer will be studied in detail. Sunscreen creams, containing UVabsorbers, can protect against the deleterious effects of UV. However, there are many drawbacks to local protection. Adequate protection is only acquired if the sunscreen is applied evenly, frequently and in sufficient amounts. Systemic delivery of photoprotectants by a simple dietary approach is an alternative and potentially more effective way to protect the skin against the harmful effects of UV. Promising photoprotectants include omega-3 polyunsaturated fatty acids omega-3 FA), vitamin E, vitamin C, and selenium. Culture media of human keratinocytes and, in some cases diets of human volunteers and laboratory mice will be supplemented with these nutrients. The effect of the supplements on the above mentioned molecular events will be investigated. In addition, bioavailability of the nutrients and antioxidant st