RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FISHING FOR MARKERS OF EFFLUENT EXPOSURE USING METABOLOMICS' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Fish populations are declining in inland waters in many parts of Europe due, in part, to the impact of aquatic pollutants on fish health. In many aquatic environments fish are exposed to effluents from wastewater treatment works (WwTW), and these can contain complex mixtures of chemicals arising from human waste. The impact of many of these contaminants and their mixtures on fish health is unknown and remains to be investigated. With future pressures on water resources resulting in less dilution of WwTW effluents in some river catchments, there is a urgent need to develop monitoring tools to assess effluent exposure and its effects on fish health.The objectives of this project are to investigate how the (bio)chemical profiles change in fish blood as a result of exposure to WwTW effluents, and to identify key (bio)chemical signatures that could be used to monitor exposure to wastewater effluents. To do this, the fellow will use the exciting omics-based technique of metabolomics. This involves the holistic mass spectrometry profiling of as many of the biochemicals as possible in the blood and, in the context of this project, will also involve profiling of chemical contaminants and their metabolites alsopresent in the samples. Fish will be exposed to WwTW effluents and the (bio)chemicals in their blood samples profiled to identify markers of effluent exposure and effect. The work will result in an array of candidate (bio)chemicals which can then be evaluated in future projects for biomonitoring of fish health in European rivers. The results will be of wide interest to the government regulatory bodies, environment protection groups, waterand waste industries and the wider public in Europe. The project will bring Dr David to work with Professor  Hill, and allow him to benefi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Ironworking technology and social complexity of rural comunities during the Early Medieval Ages'.

assistant: **Objectives**

The application of scientific techniques to analyse archaeological materials has greatly influenced modern archaeology, providing archaeologists with the tools to generate datasets, such as those associated with chronological dating and chemical compositions, from which more rigorous interpretations can be developed. The Basquesmith project aims to investigate ironworking production during Early Medieval (EM) times by applying microscopic techniques on an assemblage of materials excavated in rural settlements in the Basque Country (northern Spain), a region renowned for the superior quality of its iron products. Characterisation of the manufacture and repair methods used, the quality of the utensils produced, and the debris generated, will provide valuable insight into which production occurred at the sites. The originality lies in the artefacts themselves as well as the archaeometallurgical approach to investigate these assemblages. Common utensils such as ladles or keys made from iron, which are exceptionally rare in EM rural contexts, allow ironworking to be explored on rural implements from rural communities rather than prestige items from urban contexts. This will result in a truly utilitarian project combining history, archaeology and materials science to investigate a much neglected area for EM Spain. Basquesmith is highly committed to EU's strategy endorsed in the field of Cultural Heritage and is in an excellent position to carry out this research through the promotion of such an interdisciplinary approach. Moreover, Basquesmith integrates the applicant’s knowledge in material science with a top level research group (GIPyPAC) at the University of Basque Country. This network will not only encourage dissemination of the research within the academic literature an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mapping the Targets of Antimalarial Compounds Through Chemical Profiling.' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Malaria is one of the most devastating infectious diseases affecting half of the world population and killing close to a million people every year. Widespread resistance of the malaria parasite to most front-line drugs and the rapid emergence of resistance against new therapies have made the validation of novel pharmaceutical targets and the identification of potent pharmacophores extremely urgent. In an effort to synergize basic research with malarial drug development the pharmaceutical industry has run large phenotypic screens and identified thousands of new compounds with antimalarial activity. These hits represent a treasure-throve of chemical tools to study parasite biology. However, in order to harness the potential benefits of these hits it is crucial to determine the mechanism of action by which these compounds exert their antiparasitic activities.Here we propose a global chemical proteomic approach to identify the molecular targets of some of these bioactive molecules using broad-spectrum activity-based probes (ABPs). ABPs are small reporter molecules that use the conserved catalytic or binding mechanism of an enzyme family to covalently modify their active sites. A tag embedded within the structure of the probe allows for visualization of labeled proteins in a gel-based format. When used in a complex proteome, ABPs report on the active site occupancy of all members of an enzyme family, thus making them ideal tools to simultaneously screen dozens of targets against potential inhibitors.The goal of this proposal is to run a pilot study by screening 400 of the most promising antimalarial compounds against all serine hydrolases, cysteine proteases, and ATPases found in infected red blood cells. We will then use the latest advances in Plasmodium genetics to validat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Neuroendocrine Immune Networks in Ageing' (NINA) targeting Seventh Framework.

assistant: **Abstract**

Current demographic trends indicate that by the year 2020 almost 1 in 5 of the European population will be aged over 65. However, although life expectancy is increasing in the developed world, the period of good health enjoyed by its people is not keeping pace. The ageing population is thus a major health and economic issue for Europe. Although ageing is a complex process, we know much about its actions at the cellular and tissue level. In contrast, our understanding of how the various age-related changes interact to result in frailty and disease is incomplete. There is therefore a pressing need to carry out multidisciplinary research to identify factors contributing to age-related frailty and to develop interventions to promote healthy ageing. While Europe has many excellent research teams working on age-related diseases, such as neurodegeneration, there is little attempt to pool resources and identify underlying common age-related processes that predispose to pathology and represent rational targets for intervention. In addition, there is a lack of scientists trained in multidisciplinary ageing research and the challenge of an ageing population will not be met unless we increase research capacity in this area. NINA is a multi-site ITN that will make a significant impact upon research capacity by training 12 early stage researchers and 2 experienced researchers, integrating research and training at 10 world class European institutes. Fellows will benefit from the expertise of academic partners and training will be enhanced by the intersectoral experience provided by two industrial partners and a non-governmental organisation. NINA will tackle crucial health research challenges by directing the multidisciplinary programme at the identification of key factors driving the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Creation of innovative ""humidity to electricity"" renewable energy conversion technology towards sustainable energy challenge""'.

assistant: **Objectives**

CATCHER project is aimed at development of innovative technology to exploit the atmospheric humidity for direct conversion to the electricity, thus gain a new sustainable source of renewable energy and to contribute to implementing the specific priorities for strengthening the EU leadership on renewables.The successful realization of the project is assured by implementation of knowledge sharing in material science, physics, nanoelectronics, green chemistry, nanoengineering, sustainability and research marketing via international and intersectorial collaboration of highly qualified research and business from Portugal, Belgium, Austria, Spain, Poland and Ukraine.Up to date we developed the theoretical basis for the “humidity to electricity” conversion mechanism, delivered proof of the concept and elaborated the first-generation converter Prototype - advanced “humidity to electricity” converter within accomplished 2016-2019 H2020-MSCA-RISE-2015 HUNTER project; attested and further patented [PCT/UA2019/000147] in 2020. Project is targeted on advancement, optimization and scalability of a previously developed technology that converts atmospheric humidity into electrical current [up to date value of 3.6 mW/g or 1.82 mW/cm2], with an expected output power density of ~36 mW/g or [15 - 20 mW/cm2], which will be ready for scaling up, thus could be prepared for further integration with existed EU electrical system for general energy use.The proposed solution is expected to contribute to implementing the specific priorities for strengthening the EU leadership on renewables laid out in the Communication for Accelerating Clean Energy Innovation. Sharing the culture of research and innovation, the CATCHER project will allow applying recent advancements in nanotechnology science and en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Realising and Managing International Research Infrastructures 2' (2007-2013).

assistant: **Innovation**

This project builds on the work previously done for the first RAMIRI project. It responds to a number of developments in European research infrastructure (RI) management, including the ESFRI Roadmap, the ESFRI regional issues working group, the ECRI conferences and the European Research Area (ERA) Board. The principal aims of this proposal are to train a group of new RI-managers (with a particular emphasis on managers from the new member states) in a number of key practical areas relevant to establishing and managing RIs of pan-European and international importance, including both single-sited and distributed infrastructures in both the physical/natural and social sciences. Topics covered will include: determining socio-economic impact, site-selection, legal and governance issues, financing, project planning and construction, recruiting specialised staff, and strategic planning (upgrades, partnerships, technology transfer). These learning areas will be delivered by expert speakers coordinated by a programme committee across 2 learning programmes over 24 months. Each programme will consist of two workshops held in a different location: Amsterdam, Prague and twice in Trieste. Elettra Sincrotrone Trieste will coordinate the overall project and work closely with its partners: Adam Mickiewicz University, Imperial College London, Institute of Physics and University of Amsterdam. The workshops will also include a site visit or more detailed case study relevant to each location. Participants will be selected on the basis of suitability through an application process. A mid-term review meeting will be held in Poznan to coincide with the Polish Presidency of the EU in late 2011. Following the end of the programmes, the learning materials and case presentations will be incorporate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Functional analysis of pectic RG-I in tomato and strawberry fruit', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Available high-throughput techniques, such as genomics, underpin a new era for Big Data in Science. The application and analysis of such large amounts of information is not facile and must be combined in parallel with a detailed analysis of the functions of genes/proteins in relation to less tractable biomolecules such as glycans and ultimately cell, tissue and organ attributes. This last part of the analysis looking at the properties of biological organisms, named phenomics, is a final step of Big Data approaches and is crucial for maximizing Big Data application and usefulness. In this project I will focus on a glycomic/phenomic approach to characterise the role of the complex pectic glycan rhamnogalacturonan I (RG-I) pectin in fruits in relation to texture properties.I shall focus on two species, tomato as model for climacteric fruits and strawberry as model for non-climacteric fruits. I will take advantage of the genome sequence projects and associated publicly available tools, which will be supported by my background in both strawberry research and plant cell walls. I aim to analyse genes related to the remodeling of RG-I pectin, by functional analysis of silenced transgenic lines in both tomato and strawberry, to structurally dissect the complex pectic glycans and determine their specific roles in fruits, with special interest in fruit mechanical properties and texture.This complex quality trait produces important losses in the fleshy fruit industry. Our hypothesis is that the restriction of cell wall disassembly in fruits will contribute to improve their textural features and also result in a longer fruit shelf-life, reduced mechanical bruising during the postharvest period and more resistance to plant pathogens. This widened knowledge in high value crops of fles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evolution of viral codon usage preferences:manipulation of translation accuracy and evasion of immune response' (CODOVIREVOL) targeting Horizon 2020.

assistant: **Abstract**

Fidelity during information transfer is essential for life, but it pays to be unfaithful if it provides an evolutionary advantage. The immune system continuously generates diversity to put up with recurrent pathogen challenges, and many viruses, in its turn, have evolved mechanisms to generate diversity to evade immune restrictions, even at the cost of enduring high mutation rates.Synonymous codons are not used at random and are not translated with similar efficiency. A large proportion of viruses infecting humans, especially those causing chronic infections, display a poor adaptation to the codon usage preferences of their host. This observation is a paradox, as viral genes completely depend upon the cellular translation machinery for protein synthesis. The poor match between codon usage preferences of virus and host negatively affects speed and accuracy of viral protein translation. We propose here that maladaptation of codon usage preferences in human viruses may have an adaptive value as it decreases translational fidelity, results in the synthesis of an ill-defined population of viral proteins and provides a way to escape immune surveillance.We will address the fitness effects of codon usage bias at the molecular and cellular levels, and later at the organism level in a rabbit model of papillomavirus infection. We will apply experimental evolution to analyse genotypic changes by means of next generation sequencing and will monitor phenotypic changes through real-time cell monitoring techniques, comparative proteomics, and anatomopathological analysis of virus-induced lesions.Our results will help solve the evolutionary puzzle of codon usage bias, and will have implications for the development of therapeutic vaccines to guide the immune response towards the identifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functorial techniques in silting theory' (FunSilting) under Horizon 2020.

assistant: **Objectives**

This project aims to develop topics in contemporary representation theory by making novel connections between two different approaches: tilting theory and model theory.  Tilting theory is a set of tools that allows us to formally compare derived categories and has applications in many areas such as Lie theory, algebraic geometry and topology.  Our work will take place in the richer setting of silting theory, which encompasses traditional tilting theory but also enables the study of important abelian subcategories of the derived category that are not necessarily derived equivalent to the ring.   We will approach silting theory using techniques originating in mathematical logic, that is, we will use the model theoretic approach to purity.  It has been observed for many years that there is a connection between purity and tilting theory but the underlying reasons for the link have still not been properly explained.  Our new perspective aims to explain and deepen these connections. The key techniques we will use involve localisations of functor categories and their connection to a topological space called the Ziegler spectrum.There are two main objectives in this proposal:  firstly we will strengthen the foundations of the connection between silting theory and purity and secondly we will apply our new approach to classification problems in the representation theory of finite-dimensional algebras.The Experienced Researcher (Dr. Rosanna Laking) will work on the project under the supervision of Prof. Angeleri Hügel at the University of Verona for a period of 24 months.  In addition to the valuable exchange of knowledge between the Experienced Researcher and the large number of experts on tilting theory in the region of Verona, this fellowship will enable Dr. Laking to develop s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PROSODY EXPERIENCE ENHANCEMENT WITH MUSICAL EDUCATION' (PRE-MUS).

assistant: **Concept**

The proposed PROSODY EXPERIENCE ENHANCEMENT WITH MUSICAL EDUCATION (PRE-MUS) will bring Dr. Mualem, a professional musician and music teacher from Israel to Hull, for a postdoctoral fellowship in the cognitive psychology laboratory of Dr. Lavidor. This is an ambitious, multi-disciplinary project that has exceptional potential clinical and educational applications. The main objectives of PRE-MUS project are: 1. Characterize perceptual prosodic abilities, performance on various levels of perceptual auditory linguistic and non-linguistic related tasks, and examine the associations between them. 2. Characterize musical education (MUS) level and examine the interrelations between them and prosodic abilities. 3. Pilot intervention training in musical education and auditory skills to enhance emotional prosody comprehension. We view objective (3) as particularly important in developing methods of rehabilitation of prosody deficits found in Autism and Schizophrenia. The PRE-MUS will provide an exceptional environment for the advanced research training of the researcher (Dr. Mualem) in state-of-the-art theories and methods of cognitive psychology. The main training objective of PRE-MUS is to maximize the chances of Dr. Mualem to get an academic position in her homeland and the training program details how we aim to do so. The PRE-MUS will also provide positive role models for young female researchers in the community, as the two partners (Lavidor and Mualem) are both mothers who combine a career in Science with family life. Dr. Lavidor has already benefited from European funding under FP5, FP6 and FP7, including an ERC start-up award and a Marie Curie excellence award. Her extensive experience with EC schemes will guarantee the smooth running of the PRE-MUS project.