RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PAVEment SCANning with EGNSS Technology for Accurate Assessment' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The proposed project aims for the development to market (TRL8-9) of EGNSS-based integrated low-cost sensor technologies and artificial-intelligence-driven open-architecture software solution (machine learning (ML) and machine vision (MV)), for the detection, classification, and georeferencing of roadway pavement surface anomalies and for the low-cost assessment of roadway pavements using participatory sensing. The proposed system is of practical importance since it provides continuous information about roadway pavement surface anomalies which are valuable for efficiently monitoring the transport infrastructure and for public safety. The vision for roadway condition assessment by utilization of smartphone-like technology is set in parallel with the hypothesis that such technology can be used for crowd-sourced data collection and analysis in GIS-based pavement management systems (PMS), and that the developed technology and related transport informatics are disruptive technologies that have the potential to reshape the transport and infrastructure O&M industries through the project objectives discussed in the proposal.


**Keywords:** EGNSS sensors, transport infrastructure management, roadway pavements, anomaly detection, augmented reality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LOW ENERGY DESIGN AND INNOVATIVE BUILDING ENVELOPE ON THE GLOBORAMA BUILDING HAVING 140000 VISITORS PER YEAR' (1994-1998).

assistant: **Concept**

To demonstrate the substantial reductions of energy consumption throughout a buildings lifecycle can be achieved by combining Environmental Impact Assessment in building design and the use of new construction methods, together with existing technology and components in new and novel respects.Goborama has been nominated as host organization for a Green Guide"-function. The Green Guide is an environmental specialist, who has as her main function to support environmental conciousnes in the local community.Globorama will be an unconventional science and experience centre focusing on energy and the environenment, offering activities and exhibitions of high educational value. The low energy building design will play an interactive role with various exhibitions of high educational value. The low energy building design will play an interactive role with various exhibitions."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Intelligent and cost-efficient wind turbine power production using optical sensors' (ICEWIS).

assistant: **Innovation**

Sensors are widely used for optimization of technical systems. In most cases they are electrical, hence not safe to operate e.g. on wind turbines blades due to lightning risk, on fuel tanks, in strong magnetic fields or close to generators due to the risk of electrical short circuits. Furthermore cabling is costly, can be cumbersome to handle and signals are difficult to transmit reliably over long distances.CEKO Sensors (CEKO), a spin-out from the Technical University of Denmark (DTU), Department of Nanotechnology, will disrupt the sensor market by providing sensors that are 100% optical, frequency modulated, have very high sensitivity and are metal-free. The force sensitivity of the sensors has shown to be 1200 times larger than what can be obtained using comparable technologies. At the same time the physical size is 100 times smaller and the weight 3000 times less than other sensors on the market today. These unique features make them crucial for applications where sensitivity, size and weight are critical parameters. The initial proof-of-market application for the CEKO sensor is wind turbines. Wind turbines have been selected as CEKO sensors addresses several significant challenges for wind turbines owners: Monitoring of blade damages for reduced maintenance and repair costs, optimization of blade loads for efficient production and detection of icing on the blades, which has a high impact on the power production and the safety on ground.The CEKO sensors will initially be marketed through Brüel & Kjær, a world leading sensor manufacturer, who has estimated the direct achievable market for the CEKO sensors in the wind power segment to be 36.000 sensors/ year worth €22 million. The objectives of the over all innovation projects are to 1) finalise the development of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Estonian Innovation Relay Centre'.

assistant: **Innovation**

ESTIRC consortium will undertake activities which will contribute to the objectives of promoting transnational technology transfer, promoting exploitation of European Community research results, improving the technological capacity of firms to absorb new technologies and improving the innovation environment in Estonia. Proposers are targeting in this effort all territory of Estonia and are orienting the services towards SMEs and different research institutions. Partners will provide high quality transnational technology transfer advisory service implemented with general information and support services. All services to be undertaken will be client and result oriented and focused on the real needs and local circumstances of Estonian SMEs and research community. Main activities of the project are:1)Promoting and facilitating transnational technology transfer from other European countries to the Estonian companies2)Facilitating technology potential originating from research and SMEs in Estonia to other European countries3)Increasing the technological capacity of local SMEs to absorb new technologies4)Supporting the exploitation of Community research results5)Seeking synergies with and signposting to other European and national innovation support networks and initiatives
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Targeting telomeric DNA damage response as a new strategy to fight immunosenescence and improve vaccine response' (TELOVACCINE) under Horizon Europe.

assistant: **Objectives**

The immune system is remodeled with age, going through a series of changes known as “immunosenescence’, including the involution of primary lymphoid organs, the contraction of the immune repertoire, a progressive lineage skewing towards the myeloid lineage and a low-grade pro-inflammatory status. A consequence of immunosenescence impacting the morbidity and mortality of infectious diseases is a dramatically reduced vaccine response in the elderly. Thus, reducing the burden of immunosenescence has the potential to impact the effectiveness of vaccine response. An established hallmark and driver of age-associated functional decline is telomere dysfunction. Dysfunctional telomeres are actively transcribed to generate telomeric non-coding RNAs (tncRNA) which are essential to recruit DNA Damage Response (DDR) factors at damaged telomeres, thus fueling DDR and causing cellular senescence initiation and maintenance. Sequence-specific telomeric antisense oligonucleotides (tASOs) target these tncRNAs and effectively inhibit DDR activation, ameliorating age-related phenotypes in mouse models. The telomerase-deficient (Terc-/-) mouse model, causes telomere shortening and dysfunction, recapitulating features of immunosenescence: immune system reactivity reduction, decreased long term renewal of hematopoietic stem cells and lymphocytes numbers, increased neutrophil count. tASOs treatment has beneficial long-term effect in this model, by decreasing immunosenescence and counteracting inflammation. We now plan to test the efficacy of tASOs treatment on ‘rejuvenating’ the immune system of aged wild type mice, a ‘physiological’ setting for aging. The final goal will be to assess if tASOs impact on vaccine response in both models: young Terc-/- mice and aged WT mice. In summary, we plan to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Gripwash'.

assistant: **Concept**

Te following exploratory award will be the first stage to a proposal for a CRAFT proposal called GripWash". The subject of the envisaged project is a cleaning device, called"GripWash", and a special cleaning procedure for the cleaning of grippers of packing machines. The conceptual framework of the cleaning device exists as well as parts of the device, however, several research and development issues are still open and will be solved in the envisioned CRAFT project. Within this exploratory award, the participating SMEs will define the framework and basic tasks for the subsequent project. The envisaged outcome of the stage 2 projects will be a cooperative research project using the latest techniques and methods to develop a specific cleaning device for the brewery and packed goods' industry."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Interdisciplinary Music Practice And Quantum Computing Technologies' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Emergent technologies open new avenues for industry and society but rarely create an open and inclusive space to think through their implications. Quantum Computing (QC) currently represents a change in paradigm by offering a unique opportunity to rethink computation from its very inception. In its effects and applications, this is also the time and space to approach creative practice in an entirely new way.IIMPAQCT (Integrated Interdisciplinary Music Practice And Quantum Computing Technologies) explores ways to expand and diversify the community engaged with QC, and its epistemological and praxical connection to the Creative Arts with emphasis in Music. Recent explorations in QC and Music, as well as in the Visual Arts domain, have been pursued in isolation and even detached from contextual artistic practice and theory. The lack of real integration, that engages creative artists in the QC theoretical discussion and practical explorations, makes the distance between Art and Science even wider and hinders the sustainability of a truly diverse society, both socio-culturally and technologically.IIMPAQCT aims to develop and reinforce new interdisciplinary links connecting Arts, Science and Technology through 3 main intertwined research-work dimensions: i) an Artistic dimension promoting a network of creative practitioners engaging with QC while empowering them to be active participants in the field development; ii) a Technologic-Scientific dimension focusing on the improvement and creation of practical tools and methods towards an intersectoral innovation; and iii) a Curricular dimension that unfolds with the creation of study and research spaces in QC and Arts, as spaces for knowledge/theory construction, as well as analysis and multi-artistic creations. This project uses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Networking for Excellence in Electric Mobility Operations' (NEEMO), addressing dissemination and exploitation.

assistant: **Impact**

NEEMO aims steadily set in the Electric Mobility research, related integration of technologies, modes and operations within the MCAST Energy research Theme in Transportation from terrestrial to marine mobility and from heavy-duty vehicles to micro-mobility solutions. The issue of mobility and energy is more pregnant in geographic islands due to strong energy dependence on fossil fuel. Therefore, a Network for Excellence is created with two world-leading research institutions AIT (Austria) and CEA (France) and like Malta as a widening country with distinctive island, characteristics included Cyprus through the Nicosia Development Agency (ANEL) for social policy aspects and exchange of wider experiences.The activities are mainly knowledge transfer and networking through a series of workshops, winter/summer schools, training programmes, internships, exchanges, meetings, mentoring, conferences and joint publications as well as research outputs, mostly targeted to early stage or aspiring researchers.MCAST Energy is experiencing a self-funding growth within its breadth of energy research theme that leads on campus. In addition, the MCAST main campus infrastructure together with laboratories will be the first ‘living laboratories’ on the island, used for real-life applications while delivery training and research as well.This TWINNING proposal will provide a stimulus of required knowledge to become more efficient and competitive to an international level of excellence. NEEMO is designed for all partners to benefit in a way that goes sustainably beyond the three-year funding period. This eventually will result in enhanced skills sets and profile of MCAST Energy which in turn reflect the positive development of Malta knowledge economy including its ambition as a regional energy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Combining in vivo spectral biphoton imaging and multiparametric cytometry to characterize the dynamics of the innate immune response in a multiple sclerosis mouse model' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Multiple sclerosis (MS) disease is dependent on an intricate interplay between the adaptive and innate immune systems. Nevertheless, none of the Food and Drug Administration-approved drugs target innate immune cells, because of their unclear roles in the disease process. However, innate immune cells implication in the MS disease is no longer put in doubt.The mobilization, differentiation and spatial-temporal distribution of brain resident and recruited peripheral innate immune cells, in relation with clinical scores, will be analyzed, as an alternative source of disease biomarkers and therapeutic targets.The project combines recent advances in (a) generation of multicolor transgenic reporter mice with subpopulations of cells expressing distinct fluorophores, (b) spectral bi-photon imaging to visualize the cells of interest directly in the spinal cord in living animals, at a subcellular resolution in real time, and (c) multiparametric flow cytometry to characterize over time inflammatory cell types in the spinal cord tissue after disease induction. The activated cells converging to the neuronal lesions, as well as the delay and the effect on the neurons, will be characterized. VEGF will also be tested as potential therapeutic drug, based on the known VEGF effects on neurons and immune cells. This data will provide new insights on MS disease setting up and implicated cells, correlated with clinical scores, neuronal damages and disease progression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Process intensification methodolgies for liquid-liquid systems in structured equipment' under Seventh Framework.

assistant: **Concept**

This project has the objective to develop and validate a design methodology & criteria for dealing with two-phase liquid/liquid-reactions leading to a new generation of flexible and high-performance process equipment (micro through to meso structured) for continuous manufacturing.  This generic approach will be developed by the project members and will involve practical, theoretical and modelling aspects. The devices developed will be applied to 2 different industrial systems to show the wide applicability to the chemical industry: the mononitration of benzene and the cyclization of b–ionone. Micro and meso-scale reactors will be operated at scales relevant to commercial production to demonstrate improved selectivity, yield and specific performance. A state-of-the-art experimental research facility will be designed and constructed; this will be modular, flexible and expandable to ensure flexibility of process and operation. Having developed an improved fundamental understanding of these multiphase processes and the design and operation of appropriate micro/mesostructured environments, the partners will codify this learning, in the form of a “toolkit”, to identify the most suitable continuous processing methods for any liquid/liquid system. This will allow operators to improve the sustainability of chemicals production by selecting intensified process methods that are both eco-efficient and offer increased safety. The partners are drawn from six countries and include a knowledge transfer company, two SMEs, two manufacturers of equipment and three potential end-users thereof. Manufacturers of two complimentary continuous processing systems (micro and meso-scale) will combine forces with three end-users (two of whom in fact are engaged on pre-competitive research. The proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Somatostatin and its receptors in brain function and dysfunction' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

While the role of classical neurotransmitters in neuronal communication is comparably well characterised, the actions of neuropeptides remained largely unknown. The objective of this proposal is to provide a complete understanding of the control of neuronal communication by the neuropeptide somatostatin through an elucidation of its antisecretory and antiproliferative actions. The functions of the individual somatostatin receptors will be unravelled in a multidisciplinary approach relying on the development and application of novel experimental tools and strategies. It will become clear how somatostatin signalling affects normal and abnormal brain function. Concepts will emerge regarding novel diagnostics and therapeutic strategies that can be used to treat patients from European populations that suffer from various brain disorders including neurodegenerative diseases, mental and affective disorders and aggressive brain tumours.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Therapies for Renal Ciliopathies' (TheRaCil), addressing dissemination and exploitation.

assistant: **Impact**

Ciliopathies are a large group of rare and severe genetic diseases caused by dysfunction of the primary cilium, a microtubule-based cell surface antenna that controls key signaling output required during development and tissue homeostasis. Cilium dysfunction leads to complex disorders with high genetic heterogeneity and overlapping phenotypes. Despite the broad clinical spectrum, chronic kidney disease (CKD) leading to end stage kidney disease (ESKD) is a common cause of morbidity across ciliopathies. Currently, the only available standard of care for CKD is based on dialysis and transplantation. Renal ciliopathies represent a main cause of ESKD during childhood and despite the identification of more than 40 causative genes, it remains difficult to predict the severity of the disease as well as the risk of appearance (if not present at diagnosis) and the rate of progression of renal failure. TheRaCil therefore aims: (1) to improve diagnosis and prognosis of at risk pediatric renal ciliopathy patients, and (2) to implement therapeutic approaches aimed at targeting shared pathological pathways, at modifying mRNA targets of  the causative or modifier genes by antisense oligonucleotides and by the repurposing of available molecules. These goals will be achieved through the federation of our unique databases of pediatric renal ciliopathies cases available across Europe, which will allow a better stratification of patients, the identification of modifier genes and markers of disease progression. Bioinformatics approaches will be used to integrate patients’ biological and genetic data as well as multi-omics and functional analyses from patients samples and preclinical models. These analyses should lead to the identification of shared targetable pathological pathways as well as