RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Computational design of industrial enzymes for green chemistry'.

assistant: **Objectives**

Catalysts are able to reduce activation barriers of reactions making them possible at lower pressure an temperatures. Enzymes are the most efficient, specific, and selective catalysts known. Green chemistry has emerged as a new area focusing on use of environmentally friendly, non-hazardous and efficient solvents and catalysts in the synthesis of new products. Enzymes are non-toxic, and capable of operating under mild biological conditions, which makes them green catalysts offering an attractive alternative to traditional catalysis. However, their application in industry is rather limited as most industrial processes lack a natural enzyme. The solution is the routine design of enzymes, but this task has not yet been achieved due to several limitations, such as the high complexity of enzyme catalysis, the lack of accurate computational approaches for designing and estimating the catalytic potential of the new variants, and the inability to identify potential mutation sites far away from the active site of the enzyme. GREENZYME provides a new protocol able to capture this high complexity and design new enzymes capable of predicting active site and distal mutations, thus achieving high levels of activity (as it would occur in nature). This is achieved by integrating current Shortest Path Map-Ancestral Sequence Reconstruction (SPM-ASR)-based computational protocol developed in previous projects such as the ERC-StG NetMoDEzyme with deep learning techniques. Thanks to a well-thought-out exploitation and communication strategy, will make possible the premise of routine enzyme design. This will have a large-scale socio-economic impact, as it will reduce the production costs of many drugs and will allow industries to use environmentally friendly alternatives in line with new Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ir-Religious MAsculinities: Unpacking the gendered dialectic between Islam and secularism' in the context of a Horizon Europe call.

assistant: **Objectives**

IRMA breaks new ground and proposes an innovative approach for the relational study of gender by investigating the relationship between masculinity, secularism and religiosity among Bangladeshi-origin Muslim men in different national contexts. An ideological tension between secularism and Islam plays a prominent role in the societal debate on gender, not only in Europe, where ""Muslim men"" are often a cause for concern, but also in Muslim-majority countries that experienced conflicts between secular state and political Islam, such as Bangladesh. This tension leads most men to frame their identifications according to a polarity between Islam and secularism, and to conceive of their own masculinity as incompatible with that of their counterparts, provoking heated controversy on issues such as gender equality and LGBTQ+ rights, and posing a challenge that has found little response in academic research.  Scholars have so far paid scant attention to the topic, producing poor empirical data, and rather devoting themselves to studying ""Islamic men"" as if they constitute a separate reality from the rest of society. In addition, the scarce research does not consider how migration impacts conceptions of secularism, Islam, and masculinities. IRMA remedies these shortcomings with a multi-sited ethnography on the relationship between secular (irreligious) and Islam-inspired (religious) masculinities in Bangladesh and among Bangladeshi migrants in Italy and Switzerland. The project investigates gender, secularism and religiosity in their interaction with socio-political determinants such as social class and sexual orientation, and with the position of social actors in the geographies of power, in order to offer a more comprehensive understanding of the complex and shifting interpl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Production of antibody-cytokine fusion proteins for tumor therapy' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The overall goal of the project is to demonstrate the technical viability of a process for the production of a heterodimeric fusion protein at pilot scale. The expression system, as well as the fusion protein produced, at laboratory scale fulfills the specifications needed. Past experience has shown that it is not possible to predict whether this will be the case after upscaling. It will be necessary to address this in order to fulfill the material demand for preclinical and clinical evaluation. The objectives of the project are: - process definition of an established laboratory scale technology using a new expression system for a new product at pilot scale - provision of material for the preclinical evaluation of the therapeutic concept - consideration of regulatory requirements necessary for clinical application of the product. - presentation of the results to an extended audience such as the Animal Cell Technology Industrial Platform (ACTIP), regulatory experts and clinicians. - exchange of technology between partners to accelerate product development. This proposal combines the experience of some very skilled European groups in molecular biology (Dr. Hauser, GBF), cell culture engineering (Prof. Carrondo, IBET; Prof. Griffiths, CAMR; Dr. van Weperen, Bio-Intermediair), down-stream processing (MERCK), glycoprotein chemistry (Dr. Conradt, GBF) and pharmaceutical development (MERCK) to realise a unique demonstration project: In an ongoing project the partners have established cell lines, analytical procedures and fermentation systems for protein production at laboratory scale. In the proposed project the partners will compare different cell culture techniques at pilot scale using the minimal protein medium formulation, as used at laboratory scale, to identify the most
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ethernet Switching at Ten Gigabit and Above' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The project will:- evaluate prototype chip sets for their functionality and interoperability;- develop architectures for 10 Gigabit Ethernet high performance switch design;- develop a prototype switch to demonstrate mastery of system integration issues;- use the prototype switch to demonstrate LAN, MAN and WAN functionality and interoperability;- contribute to the ongoing standardisation processes;- study architectures and techniques for higher speed Ethernet technologies;- validate the emerging 10 Gigabit Ethernet in Europe and evaluate its impact.OBJECTIVESThe project will develop an 8 port, scalable to 64 port, non-blocking 10 Gigabit Ethernet (10GE) switch and demonstrate it over the LAN, MAN and WAN. 10GE is a developing standard and capable of working over long distances over fibre. We will evaluate performance against the standard, and see how much further it can go. We will use this experience to contribute to the subsequent standard.DESCRIPTION OF WORKThe 10GE standard will not be ratified until 2002, so much of the early work in the project will be done with pre-standardisation components:WP1 specifies the design and system architecture for a 10GE 8 port switch;WP2 studies the high speed systems engineering problems at 10Gbit/s and beyond;WP3 develops the i/o and processing for 10GE and a 10GE uplink for an existing switch (for testing purposes;WP4 designs and produces the switching fabric;WP5 develops the h/w and s/w to control and manage the switch;WP6 assembles and tests the 10GE switch;WP7 carries out an extensive program of tests with two data service providers over MAN and WAN distances;WP8 considers ways of scaling to speeds higher than 10 Gbit/s - probably 40Gbit/s;WP9 is management of the project;WP10 is a strong contribution to standards in this area
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PP2C phosphatases as regulators in development and stress-pathways: Identification of protein complexes and molecular pathways by (phospho)proteomics/metabolomics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Protein phosphorylation has been recognized as one of the most versatile mechanisms that underpin several critical adaptive and developmental processes in plants serving as fast and accurate process to message signals within the cells to generate nuclear responses. Advances in functional dissection of canonical signalling pathways demonstrate that protein phosphatases and their substrate kinases are key determinants in developmental decisions and plant stress tolerance. Plant protein phosphatases of PP2C-type are essential components opening new approaches for deciphering the very early events in cell signalling. This project, aided by the combinations of multidisciplinary cutting-edge technologies, such as proteomics, phosphoproteomics, bioinformatics, molecular biology and metabolomics, is expected to precisely identify the protein associations assembled upon stress conditions and developmental processes through PP2Cs in the model plant Arabidopsis. Research and training in highly developed technologies are expected to stimulate European competitiveness in resolution of cell signalling mechanisms by proteomic tools, uncover the links to metabolic pathways and reinforce further innovations with significant scientific impacts. “ProMet” is introducing EU priority research directions and topics, providing the advanced excellence in molecular biology, proteomics and metabolomics to carry out interdisciplinary technical developments important not only for plants but for life sciences in general. Uncovering the functions and targets of signalling components phosphatases that control key developmental and stress signalling pathways is an essential task that finally affects the environmental issues, future innovations and socio-economic impacts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Characterization of rac signalling pathways to transcriptional activation ont limphocytes. Study of upstream regulators and downstream effectors of rac'.

assistant: **Innovation**

Research objectives and content The small GTP binding protein Ras plays an important role on T cell receptor-induced regulation of transcriptional activation (NFAT activation) in T cells, acting through multiple effector pathways. One of these pathways is dependent on the GTPase Rac-1 that links Ras to transcription factors phosphorylation and AP-1 activation. The aim of the present project is to characterize the Rac-dependent Ras effector pathways that regulate AP-1/NFAT transcriptional activation in T cells. The objectives will be the analysis of the upstream pathways involved in the regulation of Rac by Ras, and the study of the proximal Rac effector pathways leading to transcriptional regulation. By the use of mutants of Ras that selectively activate different effector pathways of Ras combined with inhibitory mutants of Rac the pathways involved on Rac-dependent responses leading to transcriptional activation will be studied. The role of PI 3-kinase on Rac activation will be analyzed studying the ability of constitutively active forms of the enzyme to induce Rac-dependent responses in T cells. Mutated forms of Rac that selectively interact with specific Rac target molecules will be generated and used to establish the Rac effector pathways responsible for transcriptional activation. Constitutively active and inhibitory mutants of the Ser/Thr kinase PAK will be also generated and used to establish the role of this Rac target in T cell responses. By screening T cell cDNA libraries looking for proteins that contain the established Rac binding motif (CRIB motif) novel putative T cell Rac effectors will be identified. Training content (objective, benefit and expected impact) With the completion of this research project we expect to characterize Rac signalling pathways inv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Efficient Millimetre-Wave Communications for mobile users' (MyWave).

assistant: **Innovation**

Our society is on the brink of a new age with the development of new visionary concepts such as internet of things, smart cities, autonomous driving and smart industries. This stimulates the use of the millimetre-wave frequencies up to 100 GHz to support much higher data rates and to increase the capacity of mobile wireless communication systems. For achieving this, new system concepts such as Distributed Massive Multiple-Input-Multiple-Output (DM-MIMO) in which instead of a single base-station, the cell is covered by multiple remote antenna stations, all connected to a central unit. To overcome existing limitations, such as poor power efficiency and poor signal quality, we propose to investigate an innovative antenna system concept utilizing both silicon and III-V semiconductor technologies, advanced signal processing concepts and radio-over-fibre interconnect between a central unit and the remote antenna stations. As current doctoral trainings are lagging behind in training researchers with the right skillset to resolve future wireless communication challenges, an EID is urgently needed.MyWAVE establishes a unique and well-structured training network with leading R&D labs from European industries, universities and technology institutes in the domain of wireless infrastructure and proven track-record in joint collaborations. The 15 ESRs will form a research team that is embedded in leading industrial and academic R&D labs. The programme will strongly enhance the employability and career prospects of the ESRs by offering a high-quality consortium with in-depth training in the technical areas as well as a comprehensive set of transferable skills relevant for innovation and long-term employability. The ESRs will all spend at least 18 months of their time at industry, ensu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Smart Synergy Mechanism between Electric Vehicle Charging and Flexibility Markets' (ChargFlex).

assistant: **Concept**

Rapid integration of Electric Vehicles (EVs) in the transport sector is the key to achieving the Green Deal decarbonization targets. However, EV adoption is still low for several reasons, mainly concerns about the lack of charging infrastructure from the EV drivers' view, known as range anxiety. Many studies believe deploying more public EV charging stations (EVCSs) can ease this anxiety among EV drivers. Still, EVCSs are not yet widely available due to profitability issues and putting more stress on the grid. While the growth of the EVCSs is moving slowly, the number of household charger installations is growing rapidly. However, scarce studies have investigated the potential of household chargers in providing public charging services. Further, many households are already equipped with renewables and sell the surplus energy to the grid through local flexibility markets. With renewables, household chargers can provide cheaper charging services while minimizing the negative grid impacts of EV charging. This project intends to alleviate the range anxiety in two ways. First, we will enhance the charging infrastructure availability by encouraging households to sell surplus energy to EVs through a market framework called the charging market, besides flexibility markets. We will design a coordinated bidding strategy model from the household viewpoint based on AI to maximize profit from the two markets (Work Package 1). Second, we will improve charging infrastructure accessibility by developing an AI-based charging recommendation model to guide EV drivers on when and where to get recharged (Work Package 2). Finally, we will conduct software implementation and real-time performance validation of the proposed AI-based models (Work Package 3). The complementarity between me, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The European Service for Magnetic based Microsystems Design and Fabrication (Europractice III)' in the context of a Fifth Framework call.

assistant: **Objectives**

MAGFAB is a European service which aim is to facilitate the access, at low cost and low risk, to magnetoresistance based microsystems technologies and to shorten product development cycles. This proposal aims at providing access and solutions for the design, prototyping through Multi-Project Wafers runs, and production of magnetoresistive (MR) based microsystems. In fact the partners of this proposal have developed several techniques, methodologies, processes and solutions for the development of magnetic based microsystems. Two complementary process technologies will be offered by MAGFAB: AMR (Anisotropic Magnetoresistance) and GMR (Giant Magnetoresistance).Objectives:The manufacturing facilities active within Europractice III provide access to micromachining process technologies (both bulk and surface) and enable the realization of microelectromechanical functions and systems by the release of the mechanical structure. This proposal aims at providing access and solutions for the design, prototyping through multiproject wafer runs and production of magnetoresistive (MR) based microsystems. In fact the partners of this proposal have developed several techniques, methodologies, process and solutions for the development of magnetic based microsystems. Two complementary process technologies will be offered by MAGFAB: AMR (Anisotropic Magnetoresistance) and GMR (Giant Magnetoresistance).Work description:MAGFAB is a European service which aims at facilitating the access, at low cost and low risk, to magnetoresistance based microsystem technologies and to shorten product development cycles. These goals will be achieved by offering the customers- A global service from design to production of microcomponents for MR based Microsystems- AMR and GMR multiproject wafer service for p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'INnovation through bIg daTa and socIal enTreprEneurship' (INITIATE) under Horizon 2020.

assistant: **Objectives**

The power of big data and their applications is evident through the enormous attention they have received over the past few years, with the majority of the research focusing on solving technical and business problems. However, the challenge remains on how to harness the potential of big data in order to come up with innovative solutions on various societal problems. Big data has the potential to change the way entrepreneurs, as well as the other stakeholders of a social ecosystem, take decisions, and develop new paths to create social innovation (SI) by taking informed/data-driven decisions. Nonetheless, there is limited understanding on how social ecosystems need to change to embrace the advancement that big data entails. The purpose of INITIATE is to institutionalize INnovation through bIg daTa and socIal enTreprEneurship, and to examine how to successfully exploit big data towards achieving social good and sustainable change. INITIATE will build on the current state of the art, and go beyond it by merging and extending the findings with insights from the different stakeholders involved in the SI process (entrepreneurs, policy makers, social innovators). The project will be based on a rigorous research process consisting of systematic literature review and empirical investigations and it will develop and test a framework of best practices. Interested stakeholders will use the framework as a roadmap to successfully exploit big data for SI. INITIATE will offer practical and theoretical implications through the development of prototype applications which will clearly showcase the impact of big data on addressing societal challenges. Through INITIATE both the researcher and the host institution will benefit by the transfer of knowledge, and the researcher will develop his