RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Quantum many-body optics in structured low-dimensional systems'.

assistant: **Concept**

Understanding the propagation of light and how it interacts with matter is important in many areas of science and technology. While photons are ideal carriers of information due to their lack of mutual interactions, the ability to induce large optical non-linearities in optical media opens up exciting perspectives for fundamental research and quantum information applications. Interfacing light with individual quantum emitters has made it possible to reach remarkably strong non-linearities on the level of individual photons, which can generate correlated quantum states of light. Structured systems of regularly arranged emitters offer a unique platform with enhanced coherent light-matter coupling and highly suppressed photon losses. However, recent work has so far mostly been limited to the study of linear optics. QuLowD will explore the quantum nonlinear optics of structured emitter arrays in two complementary systems: arrays of ultracold atoms in optical lattices and arrays of long-lived excitons in twisted multi-layer structures of quantum materials. The ambition of QuLowD is to contribute to our theoretical understanding of emergent photon interactions in such novel optical interfaces from the regime of few interacting photons to the many-body physics under strong optical driving. Through close collaborations between two research group led by Thomas Pohl at TU Wien, and associated groups at the Institute for Theoretical Physics (ITP) and the Vienna Center for Quantum Science and Technology (VCQ),  QuLowD seek to combine concepts from quantum optics and atomic physics as well as theoretical solid-state physics to advance the understanding of both of these systems. In particular, I will investigate few-body physics of exciton arrays in 2D quantum materials, develop meth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Activity-dependent modulation of synapse identity' under Horizon 2020.

assistant: **Concept**

The mature brain results from the formation of precise networks between functionally and morphologically distinct types of neurons. A given neuron forms synapses with a limited number of partners and on precise subcellular localizations. Understanding what controls this specificity is mandatory not only to understand brain functions but also the aetiology of synaptopathies such as autism spectrum disorders or schizophrenia. Various molecules define the identity of each type of synapse. Furthermore, neuronal activity-dependent mechanisms sculpt and stabilize neuronal connectivity. I posit that neuronal activity controls the molecular identity of synapses and that this regulation occurs through mechanisms specific for each neuronal population, thereby regulating synapse specificity. I focus on the olivocerebellar network, which is involved in motor control and also in cognitive processes. In this well-characterized circuit, two different excitatory inputs, the climbing fibres and the parallel fibres converge on the same target, the cerebellar Purkinje cells, compete for their non-overlapping territory and possess distinct functional, morphological and molecular characteristics. Purkinje cells thus provide an ideal model to study the molecular basis of synapse identity and its regulation. In the past years, I have developed new genetic tools to dissect the molecular characteristics of the olivocerebellar network at the neuron- and synapse–specific levels. I propose to generate new mouse models to control neuronal activity, in vivo and during development, specifically in the two Purkinje cell excitatory afferents. Combining these tools, my objectives are to describe the molecular diversity of synapses, show its control by neuronal activity, and characterize the molecular de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovation-fuelled, Sustainable, Inclusive Growth' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

ISIGrowth aims to offer comprehensive diagnostics of the relationships between innovation, employment dynamics and growth in an increasingly globalized and financialised world economy, and, on the grounds of such analysis, elaborate a set of policy scenarios and deliver a coherent policy toolkit able to achieve the Europe 2020 objectives of smart, sustainable and inclusive growth. ISIGrowth brings together researchers from eight international institutions that have contributed to some of the most cutting edge areas of innovation studies (e.g. systems of innovation; technological trajectories/paradigms; industry dynamics) and areas that connect understanding of economic growth at the macro, meso and micro level. Key individuals leading the work packages have shaped these areas internationally and have expertise in managing successful international projects (including EU ones) at the highest level. The research agenda is ambitious and transformative, while building solidly on the foundations of the EC 2020 strategy (and the Innovation Union in particular), so to create policy recommendations that can both improve the EC2020 strategy as well as connect it to the fundamental need facing policy makers today in the face of one the largest financial and economic crisis in history: the relationship between innovation policy, financial market reform, and macroeconomic stimulus policy. ISIGrowth will be policy focussed, with policies emerging from a strong interaction between key theoretical insights (e.g. from Schumpeterian economics of innovation and Keynesian demand policies), with key empirical studies (using cutting edge methods in complexity science, non parametric statistics, as well as detailed case studies of business and industry histories). This theoretical and empiric
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The physiological role of ADF/cofilin in neuronal development' in the context of a Seventh Framework call.

assistant: **Objectives**

Beginning life as simple symmetric spheres, neurons undergo a complicated morphogenesis until they become integrated in functional neuronal networks. A neurons development involves migration, neuritogenesis, polarization, and axon guidance. Each of these processes relies heavily on the reorganization of the underlying cytoskeleton. From cultured neurons and invertebrates, progress has been made in identifying signalling proteins that modulate the cytoskeleton during different stages of neuronal development. Despite the progress, questions remain regarding the physiological relevance of these molecules during neuronal development in mammals. ADF/cofilin proteins (AC proteins) have been implicated in regulating actin during various phases of neuronal development. Here, we outline our plans to study the role of AC proteins during in vivo development and in regulating actin dynamics during neurite formation using the brain-specific double knockout of ADF/Cofilin in mice. These studies will provide a greater understanding of the specific role of AC proteins during neuronal development and reveal how the organization and kinetics of actin changes during neurite formation and growth. Specifically, this work will: 1) characterize the developmental consequences of AC ablation in vivo, ex vivo and in culture, 2) determine what changes occur to the actin cytoskeleton with and without AC proteins during neuritogenesis, and 3) determine the genetic relationships of AC proteins during neurite formation. The proposed work will entail a multi-directional transfer of knowledge in advancing the conceptual understanding of neuronal development and in sharing technical expertise to and from the proposed fellow, the host institution, and the European Neuroscience community at large. The wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Corn Leaf Acclimation to Water Stress: Towards uncovering the molecular network that controls cell division and expansion in the growth zone with an emphasis on the role of Reactive Oxygen Species' (CLAWS), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to study the global changes of gene expression controlling the growth processes (cell division and cell expansion) of maize leaves in response to water-stress with a specific focus on the role of reactive oxygen species (ROS) and redox homeostasis. Using Computational Biology and Bioinformatics, the results will serve to:i) construct a physical map of gene expression of maize leaves;ii) test the hypothesis that ROS are major players in the observed leaf growth inhibition under water stress;iii) contribute to the building of a model of the gene regulatory networks responsible for the coordination of cell cycle and cell expansion under non-limiting growth condition and in response to the environmental perturbation;iv) enhance the knowledge of maize gene function through the comparison with gene databases of model species (rice, Arabidopsis thaliana), whose sequencing has been completed.To achieve this, an analysis of transcript profiles (microarrays) under control and water-stress conditions will be combined with a detailed spatial and temporal framework provided by a kinematic analysis of leaf growth, with cell cycle molecular status, and with ROS and antioxidants profiles along growing leaves. These will constitute the principal data inputs to the model and will be integrated with public domain (gene and protein) expression data and with maps of metabolic pathways to help establishing causal relationships within the regulatory network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'GOCE in ocean modelling' (GOCINO) targeting Sixth Framework.

assistant: **Abstract**

The GOCINO project is a specific support action that will actively contribute to reach the pre-operational capability in ocean modelling for GMES utilizing data from the approved ESA satellite mission GOCE that will be launched in early 2006. GOCINO will disseminate the results from the EU FP-5 RTD project Geoid and Ocean Circulation in the North Atlantic GOCINA?, especially the recommendations of how to use GOCE data in ocean models, to the operational ocean modelling centres.To promote and facilitate the transfer of knowledge and the exploitation of GOCE data the project will use specific scenarios for the integration of GOCE data products into four major operational systems MERCATOR, MFS, FOAM and TOPAZ. Those systems contribute to the marine component of GMES that are developed in the EU FP-6 Integrated Project MERSEA. The dissemination to the national and regional operational centres will be carried out in conferences organised by the GOCINO project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Gene Therapy for X-linked Chronic Granulomatous Disease (CGD)'.

assistant: **Concept**

This project is focused on the clinical development of a new orphan drug that can rapidly become a new treatment option for patients with the X-linked form of chronic granulomatous disease (X-CGD). This rare primary immune deficiency of phagocytes is caused by mutations in the gp91phox gene. Affected patients are highly-susceptible to infections and develop inflammatory granulomas.  Several members of the Net4CGD consortium have already attempted hematopoietic gene correction of X-CGD using gp91 gammaretroviral gene transfer vectors. While functional correction and clinical benefit was initially achieved, problems arose, linked to insertional mutagenesis, vector silencing and lack of long-term engraftment. Net4CGD proposes future trials to achieve (i) effective transduction of hematopoietic cells, (ii) physiological expression of the transgene and (iii) long-term engraftment of gene modified cells. A new lentiviral vector (LV) was developed to express gp91phox in myeloid cells. Encouraging results obtained in preclinical studies and through the compassionate treatment of a patient, prompt us to test the LV in a multi-center study in several European centers expert in CGD, under the sponsorship of a rare disease specialist. The tasks include i) Manufacturing clinical grade vector to support clinical studies, ii) Conducting a multi-center phase I/II trial in eligible X-CGD patients, with LV gene-modified autologous hematopoietic stem cells to evaluate the safety and efficacy of the procedure iii) Ensuring high-quality and harmonization of products and procedures to facilitate future product registration iv) Obtaining state-of-the art information on biological efficacy and safety in patients by assessing immune restoration and large-scale integrome data. If positive, this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Indigenous Migration Law - Emic Visions on Borders'.

assistant: **Objectives**

Indigenous Peoples engage in de facto migration governance on a daily basis all over the world. Yet, their perspective and experiences are mostly unheard, and their laws unaccounted for. Adopting an innovative bottom-up approach, IMi-Vision aims to design an overarching legal framework governing migration that acknowledges the relevance of both Indigenous and States laws in contexts where Indigenous Peoples’ territories overlap with and span beyond the borders of States. This is fundamental to explore bordering areas that have, so far, been de jure ruled by national laws but de facto managed by Indigenous laws thereby creating legal uncertainty and contrasting praxis. Two case-studies have been selected:  one in Europe (Saami communities) and another in Latin America (Cofán communities). They offer a fertile sample to assess the first exploration of the topic.In my project, I adopt a socio-legal methodology that envisions a contextualized exploration of legal phenomena, and that is underpinned by the following two entangled approaches: legal pluralism and participatory approach. Data are collected (and co-constructed) through anthropology of law’s methods. More specifically, I will conduct interviews and engage in participant-observation during two- to three-month-long field “immersion”, and then engage in a legal and content analysis of the data to capture inter-normativity and contribute theoretically to migration (law) studies.Investigating Indigenous Peoples’ legal answers to migration will prevent the widening of the existing gap between State narratives, migration policies and empirical evidence that currently affects the relevance of responses to migration within Europe and beyond. IMi-Vision thus not only contributes to changing ways migration law and governance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Language and Brain Rhythms' (LaBRhythms).

assistant: **Innovation**

From womb to adulthood, our native language is known to shape our experience of speech. A major compound of the language to which an individual is exposed during his life is the temporal structure, or rhythm, of speech signals. Exposure to native language rhythms has been shown to strongly constrain the ability to understand and learn other languages. Yet, a comprehensive view of the processing of speech rhythms from a neural standpoint is still lacking. The LaBRhythms project will investigate the hypothesis that neural oscillations are instrumental in the processing of language-specific speech rhythms, and for the communication of speech information across brain areas. To test this, I will develop novel neuroimaging tools for analyses that will increase the spatial resolution of magnetoencephalography (MEG) to an unprecedented level, allowing for observation of neural oscillations at the laminar level in human data. The project will provide both strong theoretical and methodological advances. First, it will give new insights into the brain mechanisms of complex temporal information processing in speech. It aims in particular at reconciling the linguistic approaches in the study of speech rhythms, which emphasize the cross-linguistic variability in temporal information, with the prevailing neurophysiological framework of speech processing that for now only focused on the periodicities in the speech signal. Second, it will generate new tools for laminar MEG analysis. These tools will permit the investigation of theoretical questions on the communication between brain areas that could not be answered otherwise. For this project, I will benefit from the strong expertise of the Centre de Recherche en Neuroscience de Lyon (CRNL) in neuroimaging and neural oscillations resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'TITAN: Trusted envIronments for confidenTiAl computiNg and secure data sharing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

TITAN will enrich the EOSC Interoperability Framework (IF) with a software platform solution for confidential data collaboration and secure and privacy-preserving data processing. The platform will enable access to sensitive data sets from public entities and government agencies and will be compatible by design with the EOSC IF on the technical, semantic, organisational and legal layers. To promote community adoption of TITAN’s open-source software artefacts, the solution will be practically demonstrated in several vertical cross-border scenarios - notably in the public administration and healthcare sector


**Keywords:** trusted environment, privacy preserving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Secretion of fully folded proteins in gram negative bacteria - the genetic basis of toxin secretion from vibrio cholerae' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The ability of Vibrio cholerae to efficiently and selectively secrete cholera toxin represents a remarkable biological process and serves as a paradigm for understanding protein translocation events in bacteria. Cholera toxin is exported to the medium by a two step process which involves crossing the outer membrane as a fully folded protein.The aim of the project is to identify and characterize genes of the toxin secretion apparatus. Some genes involved in the process are homologues of genes in the pul system, found in other Gram-negative bacteria. However, evidence has been obtained that a second translocation machinery is involved. The interactions between the toxin and the proteins of the secretory machinary will be studied, with a focus on the putative outer membrane pore. Comparation between different proteins exported by Vibrio cholerae will be made to determine the similarities in secretion and to identify a secretion signal for translocaiion.