RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Provision of Expertise to GSA And Support to Enabling activities' (PEGASE), addressing dissemination and exploitation.

assistant: **Impact**

The Galileo programme has been facing a very intense period during these last three years: more than 70 R&D projects have been funded under FP6, a significant number of issues have been addressed through the setting up of advisory groups and numerous activities have been initiated on the international scene.With FP7, Galileo R&D activities are entering a new cycle, with new R&D projects and new issues to be investigated. At a time where the R&D budgets allocated to the European GNSS programme are decreasing, it is vital to maximise the exploitation of the results achieved, the benefits that can be expected from the existence of numerous GNSS-related initiatives in the European Regions and the dissemination of knowledge among the concerned actors.The proposed Coordination and Support Action (PEGASE) addresses the objectives mentioned above through a series of activities tailored to the needs of the GSA. It includes the following activities: support for the management of the Galileo FP7 1st Call projects, advice to GSA on the domains of interest, establishment of advisory expert groups on request, support to SMEs for the exploitation of results and technology transfer, coordination with national/regional/local initiatives, dissemination of information and knowledge, market monitoring.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Next Generation Causal Analysis: Inspired by the Induction of Biological Pathways from Cytometry Data'.

assistant: **Innovation**

Discovering the causal mechanisms of a complex system of interacting components is necessary in order to control it. Computational Causal Discovery (CD) is a field that offers the potential to discover causal relations under certain conditions from observational data alone or with a limited number of interventions/manipulations.An important, challenging biological problem that may take decades of experimental work is the induction of biological cellular pathways; pathways are informal causal models indispensable in biological research and drug design. Recent exciting advances in flow/mass cytometry biotechnology allow the generation of large-sample datasets containing measurements on single cells, thus setting the problem of pathway learning suitable for CD methods.CAUSALPATH builds upon and further advances recent breakthrough developments in CD methods to enable the induction of biological pathways from cytometry and other omics data. As a testbed problem we focus on the differentiation of human T-cells; these are involved in autoimmune and inflammatory diseases, as well as cancer and thus, are targets of new drug development for a range of chronic diseases. The biological problem acts as our campus for general novel formalisms, practical algorithms, and useful tools development, pointing to fundamental CD problems: presence of feedback cycles, presence of latent confounding variables, CD from time-course data, Integrative Causal Analysis (INCA) of heterogeneous datasets and others.Three features complement CAUSALPATH’s approach: (A) methods development will co-evolve with biological wet-lab experiments periodically testing the algorithmic postulates, (B) Open-source tools will be developed for the non-expert, and (C) Commercial exploitation of the results will be sou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Methodology and Tools for World-best Introduction of Innovative Market Mediation System and Services in Traditional SMEs'.

assistant: **Concept**

The project's objective is to develop and verify an innovative and practicable methodology and set of tools to analyse the company's requirements, to specify, design, select and implement adequate ICT solutions for mediation systems based on custom made internet systems for new types of trade and creating new types of services in traditional SMEs.The new methodology will bring benefits to end-users (SMEs) by savings in efforts/costs for the introduction of new mediation systems by a minimum of 40% and a reduction of risks by a minimum of 80%. This will require considerable R&D activities related to efficient modelling of business processes, methods for assessment of the needs of different customer classes, identification of new services and development of building block library covering at least 50-70% of the needs of SMEs. To ensure that the developed methods and tools achieve the specified objectives the methodology will be tested at 4 SMEs from 3 different countries and 3 different industrial sectors.Work description:The methodology and tools to be developed will cover several life cycle phases of the introduction of new mediation systems and services, starting from the analysis of the needs of the SMEs and their customers, specification of the requirements on the new mediation systems and design of the new services, including the design of the corresponding workplaces and definition of the appropriate working methods and organisation, up to the implementation phases.The new methodology has to fulfil high requirements w.r.t. to efficiency, learnability, traceability, applicabality in different industrial sectors and European regions.The project will require considerable R&D activities related to the efficient modelling of business processes to be integrated, methods
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Dream-visions and oneiric experience in Early Modern Hispanic Theatre'.

assistant: **Concept**

The aim of this project is to study oneiric sequences in Hispanic theatre of the 16th and 17th centuries as a representative dramatic mechanism of the Early Modern period. Dream and sleeping scenes played a central role in numerous plays of the Spanish Renaissance and Baroque (also known as ""Golden Age""), because they enabled the creation of sophisticated plots, complex characters and visually stunning spectacles. Considering this, the project intends to document and theorise this phenomenon by proposing a key concept: the ""theatrical dream device"". The proposal is based on a novel and interdisciplinary methodological framework, which involves approaches from literary hermeneutics, theatrical semiotics and art history. The study will examine a corpus of plays composed between 1598 and 1693, written by playwrights such as Lope de Vega, the Count of Villamediana and Calderón de la Barca, among others. The project will be working with dramatic texts, but also with archive sources, historical testimonies and graphic works, such as manuscripts, old printed editions, engravings and records of the time. It is planned that the research outputs will be made available in the form of two products. The first will be a monograph to be published in open access, which aims to contribute to the field of Humanities by making a significant advance in the understanding of Early Modern European literature and theatre. The second product will be an online exhibition targeted at a non-specialist audience, mainly EU citizens related to the sectors of culture, education and artistic creation. This exhibition will display texts, images and documentation using a cutting-edge method from the Digital Humanities, which will allow to translate and adapt the scientific research results into an in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Artificial Tissue Actuators by the 3D Printing of Responsive Hydrogels'.

assistant: **Objectives**

This proposal describes the 3D printing of hydrogel droplet networks to prepare artificial tissue-like materials that demonstrate stimulus-responsive chemo-mechanical actuation. A recent breakthrough by Prof. Bayley’s research group has enabled the 3D printing of self-supporting droplet networks which can be functionalised to allow rapid electrical and molecular communication along a specific path. As a result of this, an opportunity now exists to prepare tissue-like materials that can perform mechanical work in response to external stimuli. By printing biocompatible and responsive polymer hydrogels into droplet networks, artificial muscles will be prepared that display specific and well-defined motion. The resulting technology will be of great importance for a variety of biomaterial applications, with future European Union (EU) industrial growth as well as the public ultimately benefiting from progress in this area.This proposal is inherently multi- and interdisciplinary, involving aspects of synthetic chemistry, polymer chemistry, materials science, chemical biology and biophysics. The different expertise of Prof. Hawker, University of California, Santa Barbara (hydrogels, responsive polymers and biocompatible materials), and Prof. Bayley, University of Oxford (3D printing of artificial tissue, lipid bilayers and membrane proteins), are ideally suited for the successful completion of the proposed research objectives. Due to his prior experience and track record, the experienced researcher, Dr. Lunn, will be able to effectively drive the progression and dissemination of the proposed research. Ultimately, this project will allow one of the United Kingdom's top young researchers to spend time at one of the highest ranked materials research institutes in the world, and tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'INTRINSICALLY SAFE OPTICAL HYDROGEN SENSOR BASED ON SURFACE PLASMON RESONANCE PHENOMENON' under Fourth Framework.

assistant: **Concept**

Purpose of the project is the development and marketing of an industrial hydrogen sensor based on a new sensing technique. The analyser can determine selectively Hydrogen in gas mixtures using the reflectance of the metal palladium and plasmon resonance phenomenon. The system has been tested already at VTT.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Consortium for the AdVent of aero-Engine Demonstration and aircraft Integration Strategy with Hydrogen' (CAVENDISH).

assistant: **Innovation**

In line with the European Green Deal target of reaching carbon neutrality in the aviation industry by 2050, breakthrough technologies related to direct (100% hydrogen) combustion systems will be researched, prototyped and integrated onto a modern donor aeroengine for ground testing (starting in late 2024) in Project CAVENDISH. This aeroengine test on liquid hydrogen will be a first of a kind in Europe and the cornerstone to further in-flight demonstration, eventually leading to product development aimed at meeting Europe’s and the industry’s ambition for the entry in service (EIS) of commercial, mass-transport, hydrogen-fuelled aircraft in 2035.CAVENDISH’s second objective will be to work on system and powerplant aircraft integration with several established airframers and a supplemental type certificate organisation to define certification pathways and formulate a route to permit to fly. This activity will directly benefit the flight test of the donor engine scheduled for the next phase of the Clean Aviation programme.  CAVENDISH will also explore alternative enabling technologies in the form of a dual fuel combustor system (capable of operating on 100% hydrogen and 100% SAF) and in the form of a cryo-compressed tank system. Both these technologies will offer flexibility and could ease the introduction of hydrogen in aviation.CAVENDISH brings together expertise-leading European organizations in aeronautics, power and propulsion, combustion, fuel and controls systems and aircraft. It builds on multiple national technology programmes heralding from the UK, Germany, France and the Netherlands, and is in effect the marriage and acceleration of these technology pathways into an early demonstration and a first minimum viable product (MVP) of a liquid hydrogen combusting aero
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Combining holographic optogenetics and STED microscopy for studying synaptic plasticity in Alzheimer ’s disease' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

New perspectives are opening in neuroscience: the era of electricity is transitioning into the era of light. Super-resolution microscopy was elected “Method of the year 2008” and optogenetics “Method of the year 2010” by the Journal Nature Methods.HOLOSTED is a biophysics project using these modern optical methods to study the effects of Alzheimer’s disease (AD) on synaptic plasticity. It has two general objectives: First, improving optical methods, including STED (STimulated Emission Depletion) microscopy and wavefront shaping. For the first time, digital holography will be combined with STED microscopy. This will enable precise control of synaptic signaling and the simultaneous analysis of the neuronal response with high spatial and temporal resolution. Second, progressing the understanding of AD by examining - on the level of single dendritic spines - the role of Amyloid beta, a central protein in AD, in compromising synaptic plasticity. The potential of certain drugs to rescue plasticity will be tested.HOLOSTED provides training through research: The host, a leading lab in wavefront engineering for neuronal stimulation, will teach the fellow digital holography for optical stimulation of neurons by optogenetics or neurotransmitter uncaging. The fellow will not only be trained in physical methods, but also in biological application. Besides optics, he will learn neurophysiology and -pathology. Together with his background in super-resolution imaging this training will enable him to create a profile in Functional Super-Resolution Imaging for becoming an independent group leader.HOLOSTED creates genuine mobility and thereby enables the fellow to transfer expertise of super-resolution microscopy to France and, upon his return, competence about targeted stimulation and op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Complex chromatin systems in the test tube'.

assistant: **Objectives**

Chromatin is the physiological template of genetic information controlling the capacity of a cell's genome to store, release, and inherit biological information. The basic unit of chromatin is the nucleosome: a stretch of DNA wrapped around a core of histone proteins. Post-translational modifications of histones have emerged as key in regulating chromatin structure and dynamics and are thought to crucially control genome activity. Whereas correlative studies have begun to establish links between several states of chromatin, various histone modifications, and diverse biological processes, our knowledge of how certain histone modifications exert their biological effects on a molecular level is extremely limited.One of the principles emerging from our previous studies is that certain histone marks are acting via the recruitment of sequence and modification specific binding proteins (effectors). To get a detailed understanding of the signalling principles within the histone modification/effector protein-signalling network, we propose the reconstitution of complex chromatin systems in vitro. In particular, we intend to analyse the readout and the chromatin effects of three intriguing histone methyl-lysine marks (H3 Lys 9, H3 Lys 27, and H4 Lys 20) that have distinct cellular functions and might work via recruitment of HP1 (heterochromatin protein 1), Pc (Polycomb) and MBT (malignant brain tumour) proteins, respectively. We anticipate that our studies will result in a detailed understanding of fundamental epigenetic" regulatory pathways that cause inheritable changes in gene function and expression, but do not involve changes in DNA sequence.We believe that the implications of the proposed research could be far reaching as it is becoming clear that many human disease-states,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Employment in Europe'.

assistant: **Objectives**

The first part of this project is about employment in Europe, including the new members of the European Union. Both the level of employment and the type of jobs created will be examined. A thorough study of institutional structures and policies is proposed, with a view to arriving at conclusions about their influence on job creation and about the best policy needed to achieve national or European-level employment objectives. Job creation is investigated at the two-digit level and male and female employment, wage inequality and the role of policy will be studied in depth. The research will build on solid theoretical microfoundations taking into account the choices available to firms and workers/consumers about working at home or in the market and buying domestic or foreign goods. The project has a second part about unemployment, with special emphasis on recession. The same emphasis on institutions and policies as for employment is given to this part. A key component of the project is new theory on the evolution of institutions and policies in markets with friction, and on the impact that the policy changes that took place after the recession of the 1980s have had on the responses of European labour markets to the recent recession. Special attention will be given to the formerly planned economies and the reasons for their slow convergence to the western economies.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network' (SYNTRAIN).

assistant: **Innovation**

Breast and ovarian cancer constitute serious health challenges in the EU. To identify new improved cancer therapeutic approaches, we will pursue a multi-facetted synthetic lethal approach, which takes advantage of the inherent genetic instability of cancer cells. Most mutations acquired by cancer cells do not cause lethality, but the very same mutations may cause cell death when a second gene in a redundant pathway is inactivated. Thus, targeting a gene that is synthetic lethal together with a cancer-specific mutation will kill only cancer cells while sparing normal cells. Synthetic lethal approaches have been clinically pioneered by members of our consortium, by combining cancer-promoting mutations (e.g. in BRCA2) with inactivating combinations of DNA repair genes. We will use this approach as the scientific frame for our ETN (SYNTRAIN) consisting of 9 academic and 1 SME beneficiary as well as 3 partners. We aim to identify synthetic lethal interactions and exploit them to innovate future breast and ovarian cancer treatments through compound screening and development. SYNTRAIN consists of World leading researchers with complementary knowledge in genome maintenance and stress response pathways, and a critical mass of expertise for providing an excellent training in screening methodologies, mechanistic investigations, and drug discovery. We will offer a structured training program that exceeds the capacities of each individual member. We will educate a future generation of cancer researchers with a high innovative capacity and skills that enhances their career prospects in both academia and industry. Our aims are to train young researchers: i) in techniques preparing for a career in cancer research, ii) in complementary skills relevant for work in academia and the pharma