RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A functional genomic approach to measuring stress in fish aquaculture', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The primary objective of this study is to develop whole animal gene expression profiles to identify candidate genes which are associated with resistance to various stressors in rainbow trout. Information obtained from genomic expression profiles of stressed fish is a necessary base for further development of a marker-assisted selection strategy.The primary goal will be achieved by utilising DNA micro-array technology together with whole animal physiology to address several subsidiary objectives:1-The gene expression profiles of selected tissues will be determined in fish exposed to standardised stressors.2. Genes whose expression is linked to adaptation response to stress will be identified.3. The difference in gene expression profiles between selected trout, which display a divergent trait (stress responsiveness, growth, salinity adaptation) will be used to identify potential candidate markers of genotypic variation in stress responsiveness.The work programme is divided into three phases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Advanced signal processing of time-domain data in mass spectrometry to leverage life sciences'.

assistant: **Concept**

Advances in biotechnology, pharmaceutical and life sciences require improved performance of even the most powerful analytical techniques to target the extreme complexity of modern biological samples. Due to its high performance, Fourier transform mass spectrometry (FTMS) is the central analytical technique in biomolecular analysis. Fourier transform (FT) drives FTMS by converting the time-domain (transient) data to mass spectra which, in turn, provide the biological information. Although FT is robust, it is inherently slow due to its strict uncertainty principle. Thus, many life sciences applications of FTMS are suffering from a limited throughput – data acquisition in FTMS should be done faster! Recent innovation results of our ERC Starting Grant “Super-resolution mass spectrometry for health and sustainability” have revealed the incredible power that methods of advanced signal processing, whose uncertainty principles are less strict than the FT one, have to offer to the everyday routine high-performance FTMS. Thus, we have rationally implemented existing and developed novel super-resolution and advanced signal processing methods to substantially speed up FTMS. While fundamental and technical feasibilities of our approach have been evaluated favorably at the lab level, turning these research outputs into a commercial proposition is yet to be demonstrated. Therefore, the aim of Time2Life is to translate our technology validated in lab into a robust industry-grade technology that accelerates high-performance biological mass spectrometry via the advanced signal processing of time-domain (transient) data and thus leverages life sciences applications. The industrial and academic end-users would be able to identify and quantify more analytes (e.g., peptides, proteins and met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanomedicine upscaling for early clinical phases of multimodal cancer therapy' (NoCanTher), addressing dissemination and exploitation.

assistant: **Impact**

This project has been amended in July 2019 to better align the described tasks and timeline with the current status of the project.The preceding Multifun Consortium (FP7 project Nº. 262943) has developed and validated distinct nanoformulations as therapeutic approach against pancreatic and breast cancer. These nanoformulations are based on magnetic iron oxide nanoparticles (MNP) multifuntionalised with a target peptide and an anticancer chemical drug, allowing for a synergistic therapeutic effect produced by the combination of intracellular drug delivery and magnetic hyperthermia. In particular, some of the designed formulations (patent filed PCT/EP2015/056631) have proven their efficacy, safety and non-toxicicty, in in vitro and in vivo studies, against the mentioned cancers, thus making them promising candidates to produce a novel nanomedicine therapy for cancer.NoCanTher aims at translating one of these nanoformulations to early clinical development for pancreatic cancer. Particularly, we plan to assess bare nanoparticles (System B) and multifunctional nanoparticles (System A) in advanced preclinical models and run a clinical study with the System B. To successfully reach this objective, we will concentrate our efforts in two main group of activities:• Nanotherapeutic up-scaling under Certfified conditions: NoCanTher will scale up the manufacturing of the proposed nanoformulation from milligram-scale laboratory synthesis up to multigram-scale production to generate sufficient material for clinical and regulatory assays. To this aim, a certified production line will be optimised and the relevant quality control will be conducted at the different stages of the up-scaling process.• Clinical Study: NoCanTher will include late preclinical parameter testing to raise a clin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nuclear observations to improve Climate research and GHG emission estimates' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Radon is an unique atmospheric tracer, and high-quality measurements of direct atmospheric radon concentration complemented by indirect (by progeny) measurements at a key unique location in the Atlantic will open up multiple possibilities for climate science, as well as in terms of radio protection and nuclear surveillance. The radon observations will provide an accurate time-varying baseline reference level for European GHG enabling clearer distinction between emissions and slowly changing background levels. In addition to GHG baseline estimates, the quantification - based on atmospheric radon concentration - of the degree of terrestrial influence on air masses will significantly assist multiple atmospheric and multidisciplinary environmental studies. These will be addressed in the project, including the quantification of pollution events, the investigation of the feedback of natural planktonic communities occurring at the surface North Atlantic to GHG emissions, and atmospheric studies of marine boundary layer clouds and aerosols. The project will also increase understanding on wet deposition and meteorological processes influencing ambient gamma dose rate that need to be taken into account in setting threshold alarm levels of nuclear surveillance networks for radiological protection purposes.


**Keywords:** radon,  gamma dose rate,  climate change,  GHG emissions,   radiation protection,  natural background,  wet deposition,  air quality,  air pollution,  aerosols,  cloud properties,  atmospheric ionisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Embedded Nanoscale Ferroelectric Dynamics: Characterisation and Control of Domain Wall Motion for Reconfigurable Functional Materials' (ENFOLD).

assistant: **Innovation**

Ferroelectric domain walls are dynamic nanoscale interfaces with functional properties distinct from the bulk, offering a potential route to next-generation nanoelectronics and platform for studying exotic topological states. They can be created, moved, and reconfigured by external stimuli including electric fields, strain, and temperature, enabling reversible control of conductivity and other local responses. Recent discoveries have suggested that complex polar topology can emerge dynamically during domain wall motion, with the prospect of realising multiferroicity in non-magnetic systems. Yet, systematic control has been limited by the difficulty of probing and directing these dynamics at the necessary length scales.ENFOLD aims to  exploit the unique capabilities of scanning transmission electron microscopy (STEM) to systematically control the motion of ferroelectric domain walls and characterise the emergent behavior associated with domain wall dynamics at high spatial  resolution.  STEM offers multimodal sensitivity to structure, polarisation, strain, and electronic states, and allows in situ application of electric fields to drive domain wall dynamics. By coupling these measurements with advanced machine learning approaches, ENFOLD will overcome bottlenecks in disentangling polar, elastic, and magnetic signatures from complex datasets, and enable closed-loop, systematic control of domain wall motion to tune and optimise functional properties.By moving beyond static characterisation, conventional analyses, and manual control approaches, ENFOLD will establish a mechanistic nanoscale understanding of how electric fields drive domain wall motion and the emergence of novel embedded phases. This will provide the foundation for the systematic, on-demand design of reconfig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evidence-based ICT tools for weight loss maintenance' under Horizon 2020.

assistant: **Concept**

Most adults who try to lose weight fail to maintain it. Obesity is a key economic and healthcare challenge for Europe. Effective interventions and commercial programmes for weight loss are widely available, but most people re-gain their lost weight. Currently few comprehensive solutions exist to help Europeans manage weight loss maintenance (WLM).Current research suggests the most promising evidence-based behaviour change techniques for WLM are self-monitoring, goal setting, action control, building self-efficacy and intrinsic motivation. Recent research also suggests that stress management and emotion regulation skills are key enablers of relapse prevention and weight-regain.Information technology offers attractive tools for teaching and supporting these techniques, some of which are currently delivered through resource-intensive face-to-face therapies. ICT-delivery includes networked-wireless tracking technologies, weighing-scales and activity sensors, online tools and smart-phone apps, multi-media resources and internet-based support. A broad choice of tools is most likely to be acceptable to users, who can pick and choose their own preferred technologies. The NoHoW project tests whether ICT-based delivery of the most promising evidence-based behavior change techniques is effective for WLM. We will carry out a large-scale international 3-centre trial of information technology tools that implement the most up-to-date behavioural science research. This trial will establish the effectiveness of these ICT tools in supporting WLM, linked to studies of European consumer needs and behaviour.Impact: The project will directly feed results into development of new products and services from the UK’s largest commercial weight-loss provider, Slimming World providing immediate ben
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Galileo User Support Transport', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

GUST project will provide the EC with support in the field of satellites navigation terminals during GALILEO development. Three objectives are considered of first importance by the consortium. Firstly, to support the standardisation process of GALILEO receiver by drafting a preliminary technical specification of GALILEO receiver, with an emphasis on receivers related to safety critical applications. Secondly, to give technical and operational guidelines in order to ensure certificability of GALILEO receivers. Thirdly, to provide the EC with support and expertise during its discussions with USA and Russia related to signal and receiver design. Main outputs will consist in a preliminary specification of receivers and guidelines to ensure certificability. Objectives:EC is initiating the development of GALILEO, it is therefore vital that EU prepares actively in order to significantly increase its existing market shares and strengthens its positions and to ensure that when developing GALILEO the EU receiver manufacturers, integrators and service providers could compete on the global market. The objective of this project is to support the EC in the field of GALILEO terminals during GALILEO development. There are three main issues that are to be considered. Firstly, early pre-standardisation to support the standardisation process of GALILEO receiver by drafting a preliminary technical specification of receiver, notably for safety critical applications. Secondly, receiver certification to give technical and operational guidelines in order to ensure certificability of GALILEO receivers. Thirdly, compatibility with GPS and GLONASS signals: to provide the EC with support and expertise during its discussions with USA and Russia related to signal.Work description:Given the objective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The oligosaccharide signalling in plants network' (SACC-SIG-NET) under Fifth Framework.

assistant: **Objectives**

The participants in the project are all recognized International experts in different fields of oligosaccharide signaling and recognition and run active groups with experience of collaborative research. The aim of the project is to train young European post-doctoral researchers using an integrated research project in which multidisciplinary approaches and modern technologies will be used. The training programme will involve in-house training, secondments to different network laboratories, thematic workshops and exposure to European and international conferences. In addition to training in research and technical methodology, the project will promote training in communication and organizational skills through the active participation of the young researchers in all aspects of the project. Thus the integrated, multidisciplinary approach to a project of industrial relevance, led by experts, is aimed towards enhancing the career prospects of the trainees.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Leap-to-Lead platform for expanding Drug Discovery beyond its current limits', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Health and wellbeing are among the basic and most important needs of humanity. Medicines have a major impact on the quality of life and are essential for treating various diseases. Despite the numerous achievements of the pharmaceutical industry, there are still diseases without effective treatment. Pharmaceutical industry is continuously searching for new compounds that can become drug candidates against such diseases. Development of one new drug can take about 15 years, cost up to 2-5 billion USD and includes several steps of research and development. The first step of the process is called drug discovery. Our company, BioBlocks is a collaborative medicinal chemistry research organization focused on drug discovery from initial lead discovery to development candidates, serving the needs of our clients: pharmaceutical and biotech companies. Answering to our identified clients’ need, using our experiences, we have developed and patented the Leap-to-Lead™ (L2L) concept, with the aim to expand Drug Discovery beyond its current limits. L2L consists of two major components that work in concert a Comprehensive Fragment Library (CFL), a proprietary collection of available fragments, and Syntheverse™, >500 Billion compound database. The next phase of platform development will expand its scope towards meeting its full potential: making it routine to identify viable new chemical matter for biological pathways that do not have a traditional target. We aim to speed up adding novel physical scaffolds to the CFL, for which we need to improve our internal chemical technology tools, and increase our resources for the project. Thus, we need to get external funding, such as investment and/or grant, e.g. SME Instrument Phase 2.  We intend to make a convincing, detailed business plan that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High-order Numerical Schemes for Kinetic Models with Applications in Plasma Physics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the proposed research, we will devote to the mathematical and numerical analysis of kinetic models. Kinetic theory has wide applications in physical and social sciences, such as plasma physics, semi-conductors, polymers, traffic networking etc. On the one hand, we want to propose and analyse systematic numerical methods for nonlinear kinetic models which have some challenging difficulties such as physical conservations, asymptotic regimes and stiffness. On the other hand, applications to plasma physics will be investigated, which are mainly high dimensional problems with multi-scale and complex geometries. Moreover collisions between particles for large time scale simulation need to be taken into account. We would like to develop a class of less dissipative high order Hermite methods together with weighted essentially non-oscillatory (WENO) reconstructions to control spurious numerical oscillations, and high order asymptotic preserving (AP) discontinuous Galerkin (DG) schemes with implicit-explicit (IMEX) time discretizations for multi-scale stiff problems under unresolved meshes. More importantly, these developed numerical methods would satisfy the positivity preserving (PP) principle, such as positive density distribution functions for kinetic descriptions, which is often violated by high order numerical methods with physical meaningless values. This project will combine the expertise of the Experienced Researcher Dr. Tao Xiong in high order PP flux limiters and high order AP DG-IMEX schemes, and the Host Dr. Francis Filbet in mathematical modellings and numerical tools for kinetic equations. The developed approaches will be translated to the study of turbulent plasma physics such as 4D drift kinetic, 5D gyro-kinetic and 6D kinetic models etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High quality and cost-effective metal powder for manufacturing lower weight components with improved properties for transport vehicles' to be submitted under Horizon 2020.

assistant: **Abstract**

3D Printing (or Additive Manufacturing (AM)) is a disruptive technology that produces light,  high strength components (allowing a weight reduction of 40–60% in the engines, turbines, turbochargers, and structural parts) and novel complex geometries. In addition 3D printing does not require tools, which means that component manufacturers consume less energy and raw materials.The problem is that raw materials used in 3D printers are conventional materials that have been adapted for 3D printing and they lack the specific technical properties required for aircraft and automobile components, and are also very expensive. Despite the potential benefits of 3D printing, the result is that the 3D printing production costs are prohibitively high in comparison to conventional methods, while the quality of the final components is worse.INNOMAQ21 SL (INNO) is a Spanish SME that has designed an atomiser that uses a new technology that produces high-quality metal powders at lower cost.Therefore, INNOPOWDER is a high-quality and cost-effective metal powder for manufacturing transport components through 3D printers. INNOPOWDER has been designed and optimised by our material engineers and it has superior characteristics compared to the currently commercially available metal powders.INNO aims to use the SME instrument to scale up the production of INNOPOWDER and bring it to the transport market, achieving a total profits of approximately 15M€ by 2023 and providing 28 new jobs, with a ROI on project costs of 423% after 5 years.