RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Smart electrode for nerve sensing'.

assistant: **Objectives**

Neuroprostheses, for rehabilitation of basic neurological functions in persons with spinal cord injury, should be improved by the use of feedback signals. Internationalneuroprosthesis research centres propose to design efficient sensing systemising natural sensory signals. Compared to existing recording nerve electrodes, the SENS smart electrode will improve signal-to-noise ratio and selectivity.lndeed, twill take advantage of the spiral cuff nerve electrode and include a multicontactthin conductive film. Recorded signals will be amplified, digitised and multiplexed using an encapsulated ASIC directly installed on the nerveelectrode. An implanted monitoring unit will process the multiplexed signals coming from 2 to 4 smart electrodes. Through a trancutaneous link, it will communicate with, and be supplied by an external interface located outside the skin. Thefully-validated SENS system would then be used in closed- loop neuroprostheses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Vascular inflammation and atherosclerosis' under Seventh Framework.

assistant: **Concept**

Atherosclerosis is an immunoinflammatory disease of the arterial wall that carries an important socio-economic burden. Atherosclerotic lesions contain activated T cells and specific cytokines along with immunoglobulins. Several studies have shown that atherosclerotic patients develop a perturbed inflammation toward arterial proteins suggesting that autoimmune processes may play a role in atherosclerosis progression. Moreover, patients with aggressive inflammatory diseases such as autoimmune diseases, including SLE, rheumatoid arthritis and type I diabetes, exhibit a higher incidence of atherosclerosis and are at significant risk of premature cardiovascular disease. The continued emergence of cardiovascular diseases and accelerated atherosclerosis in a wide variety of autoantibody-driven diseases emphasizes the need to identify early diagnostic markers and immunotherapeutic targets for the treatment of these complications. The specific hypothesis is that the initiation and progression of atherosclerosis is regulated by autoantibodies directed toward vascular wall components, defects in immune complex (IC) and autoantibody clearance. Our long term goal is to understand the cellular and humoral immunity/autoimmunity basis of atherosclerosis. We will focus our study on analyzing the inhibitory Fc type IIB receptor of immunoglobulin G (FcgRIIB) for the creation of the mouse line of autoimmunity. FcgRIIB is critical in controlling excessive antibody production by B lymphocytes, regulating macrophage reactivity and controlling autoimmunity. We propose to modulate the expression of this “suppressor” of autoimmunity in a hyperlipidemic mouse background. Our specific aims are: Aim I- To create a mouse model that combines of autoimmunity and hypercholesterolemia by silencing the F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genetic and Epigenetic Networks in Cognitive Dysfunction' (GENCODYS) targeting Seventh Framework.

assistant: **Abstract**

Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology approach to gain insight into common mechanisms leading to cognitive impairment: (1) Identification of genes involved in cognitive disorders. Despite considerable progress in the identification of genes underlying CD, the majority of causative genes in CD remain unidentified. Therefore, our first objective is to identify new genes causative of CD by implementing high-throughput strategies. (2) Elucidation of molecular networks that are commonly disrupted in CD. Recent genetic and neurobiological research revealed evidence for a number of molecular and cellular pathways that are shared by the various genetic CDs. Prominent examples are Rho GTPase-related genes and genes that regulate chromatin structure/function (epigenetics) associated with mental retardation and autism. Our second objective is to systematically explore this concept by elucidation of molecular networks using functional genomics strategies in genetic models that are the cornerstone of neuroscience, such as mouse and fruit fly. (3) Identify genetic modifiers and small compounds that modulate the disease phenotype. Our third objective is to resolve the molecular underpinnings of the large degree of clinical variability that is typical for all types of CD, even among patients carrying identical gene mutations. Genetic modifier screens in cultured primary neurons as well as in available Drosophila models for CD will be used to reveal phenotypically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'International workshop on palaeoflood and historical evidence in flood risk assessment' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The PHEFRA workshop will bring together scientific experts with an interest in using palaeoflood and historical flood evidence to extend the record of extreme flood events, and it will be an appropriate forum for critical discussions of methodological issues. The technical sessions will disseminate results obtained by ongoing EU RTD projects corresponding to the 5th Framework Programme as well as previous national and international projects. The workshop will comprise 2.5 days of technical sessions and 1.5 days of field visits to relevant historical and palaeoflood sites. Technical sessions will be comprised of invited keynote speakers, whereas external contributions will be presented in poster format. A stand with on-hand demonstrations on statistical software and GIS applications will be installed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'NonEquilibrium MOlecular processes in the ultrastrong coupling regime'.

assistant: **Concept**

The manipulation of the electromagnetic environment of molecular systems provides a way to control their properties and dynamics. Specifically, under strong coupling conditions, the formation of hybrid light-matter states delocalized over a large number of molecules has been shown to change the rate of chemical reactions and modify diverse transport phenomena. Despite considerable theoretical and experimental efforts, the ultimate physical mechanism responsible for these effects is not well-understood, mainly because of the complexity of these systems. Molecules present multiple internal degrees of freedom, which makes their theoretical description unmanageable when dealing with macroscopically large ensemble sizes. Besides, the phenomenology when entering the ultrastrong coupling regime is largely unexplored, where new theoretical challenges come into play. The objective of this action is to provide the missing theoretical and computational frameworks to study the dynamics of realistic molecular systems ultrastrongly coupled to a complex electromagnetic environment. Starting from the full multimode cavity QED Hamiltonian, we will first derive the effective model for such physical settings including effects that have been missed so far but are nonetheless important to address the observed (as well as the accessible) phenomenology. Then, we will apply many-body numerical techniques from quantum optics to describe the dynamics of strongly-driven, ultrastrongly-coupled systems. With these tools at hand, we will study nonequilibrium effects in these platforms, specifically energy transport and driven-dissipative phase transitions. The outcomes of this project will thus bring us closer to the definite understanding of the phenomena afforded by molecular strong coupling, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification of new regulators of Acetylcholine receptor using the nematode Caenorhabditis elegans' to be submitted under Horizon 2020.

assistant: **Abstract**

Acetylcholine receptor is an essential component of central and peripheral nervous systems which plays a key role in numerous physiological and pathological processes. In particular, acetylcholine receptor is responsible for the coupling between nervous and muscular system at the neuromuscular junction as they are activated following acetylcholine release from neurons to triggers muscle contraction. Despite extensive work to decipher the molecular properties of the receptor itself, how the activity of the receptor and the signal following its activation are modulated is still poorly understood. This is yet an important question to address as impairment in acetylcholine receptor-associated signalling is involved in neuromuscular pathologies such as myasthenia gravis or congenital myasthenic syndrome. Here, we propose to use the genetic animal model Caenorhabditis elegans to study the dynamic regulation of acetylcholine receptors. This nematode is a powerful tool to study acetylcholine receptor as this animal also uses acetylcholine as an excitatory neurotransmitter at the neuromuscular junction. In nematode, acetylcholine receptors are sensitive to levamisole, a specific agonist. Prolonged exposure to levamisole leads to hypercontraction of the worms and finally to their paralysis. However, mutations in genes associated to acetylcholine receptor activity or biosynthesis enable the worms to adapt to levamisole. In this project, using proteomic and genetic approaches based on levamisole adaptation, we will identify several new regulators of acetylcholine receptor and of the associated signalling pathway. Deeper functional characterization will be performed on the new regulators evolutionary conserved that then may be involved in some neuromuscular pathologies. This researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Resolving sEx DIffeREnces in proCessing sensory informaTion' (REDIRECT).

assistant: **Innovation**

Mental disorders are associated with abnormal sensory information processing (SIP) at preadolescence, especially in males. Aberrant SIP is a neutral cross-disorder trait that can be translated between humans and animals and assessed as the inability to prevent/gate an overload of irrelevant information. The mechanisms underlying physiological and pathological SIP variability are unexplored. Particularly, the causative role of hyperdopaminergia, key to SIP deficits, has never been tested by isolating, spatially and temporally, this single neural component. How does this trait evolve into a mental disorder? Why does it occur more often in males? REDIRECT will capitalize on our rodent model of prenatal cannabis exposure (PCE), which is the first of its kind to offer, at preadolescence, a sex bias in susceptibility to SIP deficits upon acute exposure to stress or cannabis. This animal model is amenable to molecular interrogation to probe causality for those resilience-promoting factors preventing females from developing a hyperdopaminergia and SIP deficits. By combining viral strategies to trace and probe cell-type specific input-output reorganization of dopamine circuits (Aim 1), with single-cell transcriptome analyses (Aim 2), REDIRECT will decipher how female sex imposes distinct molecular changes to neurons and circuits, which are key to prevent the etiopathogenesis of SIP disorders. By testing selected candidate genes to probe causality for how sex modulates genes, developmental trajectories, and behaviour, we will decode (Aim 3) how discrete dopaminergic circuits can be reprogrammed sex-dependently.REDIRECT will causally disentangle how sex differently affects genes, circuits, and behaviour to inform novel sex-specific and age-tailored therapies for SIP deficits, a cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Failure, performance and processing prediction for enhanced design with non-crimp fabric composites (FALCOM)'.

assistant: **Innovation**

The FALCOM proposal addresses two main objectives of KA4: improving aircraft efficiency and reducing aircraft development cost and time to market. The proposed work aims to achieve these objectives by means of a more efficient and confident use of low-cost composites based on resin-infused non-crimp fabrics (NCF), which constitute an affordable solution to safety critical primary structures. These materials will be characterised and predictive models developed with special emphasis on understanding the relationships between processability and performance.Cost and certification issues will be addressed to promote the confident introduction and use of NCF composites in aerospace primary structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Raster data management in databases' (RASDAMAN) under Fourth Framework.

assistant: **Objectives**

The RasDaMan project focuses on comprehensive database management system(DBMS) support for raster data of arbitrary size and dimension over arbitrary base types, so-called Multidimensional Discrete Data (MDD).Adequate modelling of raster data types ensures that the DBMS knows about the exact application semantics. A coherent, orthogonal query sub language allows for intelligent, optimizable retrieval. The query result will be delivered to the client in whatever form the application ordered it, be it an array in the target machine's main memory representation or some image exchange format like GIF or JPEG, thereby achieving data independence. Together with a novel storage architecture based on a combination of tiling and geo-indexing, this will minimise disk fetches, networks traffic, and compression/decompression overhead. Data compression becomes an internal feature invisible to the application and taylorable to each client's actual needs.Transparent media integration of hard disk, CD-ROM jukeboxes, tape archives, etc. will free applications from low-level access tasks. In summary, applications will be relieved from many low-level, costly, repeating tasks by providing appropriate services through the DBMS.A fully fledged raster DBMS demonstrator with the features described above will be developed and implemented by extending a commercial object-oriented DBMS with raster management features. A general raster benchmark suite will be developed which will be made available to the scientific community for comparison with other approaches. To assess practical feasibility, the industrial partners: STI and TransExpert, will implement pilots for pivotal application fields, namely medical imagery/Picture Archiving and Communication Systems (PACS) and Geographic Information Syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Technical eXperts Overseeing Third country eXpertise'.

assistant: **Objectives**

It is widely recognised that scientific efforts need to be coordinated to strengthen the knowledge base in support of policy-making in a global context. This is a complicated task that requires effective coordination and cooperation among States, RFOs and other agencies. States with an obligation to ensure sustainability of the resources they exploit should seek (i) to promote responsible fisheries and (ii) to promote good, coordinated scientific research. In the case of the EU, actions should be consistent with major international agreements (UNCLOS, CCRF, UNIA, WSSD) and contribute to improving coherence between different EU Policies.   The purpose of this Coordination Action is to facilitate a coherent approach towards research directed at the assessment and management of fish resources. The targets are particularly those areas where the European fleet is fishing in international or third country waters, or where the EU has important development goals. Thus, the principal objectives of TXOTX are:  • To collate information from all RFMO/RFOs and Fisheries Partnership Agreements as well as selected additional regions of special interest (with emphasis on CPA areas) on the extent of scientific research programmes being undertaken by the various actors. •  To analyse the data available and methodologies applied in assessment and management procedures regionally, in order to identify data and research gaps and opportunities for greater research coordination that may be promoted by the EU in support to scientific advice to fisheries management.  •  To develop recommendations on how to improve cooperation with third parties in order to enhance research and resource status  The TXOTX consortium proposes to build a network of scientists in countries with a strategic geographi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hybrid WIPS Design code' (HETEMS), addressing dissemination and exploitation.

assistant: **Impact**

In this propsal we will develop a hyrbid low power ice proection modellisation tool. This will consist of combining our existing knwoledge on separate electrothermal and electromechancial ice proections systems into a single, integrated, computer code. We will also test (but not manufacture, which is a separate CfP) a hybrid Wing Ice Protection System (WIPS) in an icing wind tunnel. The data gathered during the icing wind tunnel test will be used to validate the new design code
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Advanced Multi-Variate Analysis for New Physics Searches at the LHC'.

assistant: **Objectives**

With the 2012 discovery of the Higgs boson at the Large Hadron Collider, LHC, the Standard Model of particle physics has been completed, emerging as a most successful description of matter at the smallest distance scales. But as is always the case, the observation of this particle has also heralded the dawn of a new era in the field: particle physics is now turning to the mysteries posed by the presence of dark matter in the universe, as well as the very existence of the Higgs. The upcoming run of the LHC at 13 TeV will probe possible answers to both issues, providing detailed measurements of the properties of the Higgs and extending significantly the sensitivity to new phenomena. Since the LHC is the only accelerator currently exploring the energy frontier, it is imperative that the analyses of the collected data use the most powerful possible techniques. In recent years several analyses have utilized multi-variate analysis techniques, obtaining higher sensitivity; yet there is ample room for further improvement. With our programme we will import and specialize the most powerful advanced statistical learning techniques to data analyses at the LHC, with the objective of maximizing the chance of new physics discoveries.We aim at creating a network of European institutions to foster the development and exploitation of Advanced Multi-Variate Analysis (AMVA) for New Physics searches. The network will offer extensive training in both physics and advanced analysis techniques to graduate students, focusing on providing them with the know-how and the experience to boost their career prospects in and outside academia. The network will develop ties with non-academic partners for the creation of interdisciplinary software tools, allowing a successful knowledge transfer in both dir