RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced Biopsychosocial Simulation for Harmful Adolescent Behaviour' (LIFECOURSE-ABM) under Horizon Europe.

assistant: **Objectives**

We, the LIFECOURSE team, have been developing a theoretical framework that combines biological, social, and psychological data into unified concepts over the past five years. We now have a combined biopsychosocial data framework that can be used to uncover and understand biosocial causal pathways to adolescent behaviour, including self-harm, suicide, substance-use, and delinquancy. To our knowledge, we possess the only linkage of high-quality biological, environmental, and social data across several developmental stages of life to matched longitudinal data (N=4000). In the proposed proof of concept we propose to build a computational infrastructure on this framework, creating a fully digitized toolkit that can benefit from digital automation, communication, and artificial intelligence methods. At the center of this strategy is a new detailed biopsychosocial computer simulation model. This first stage of development  a proof of concept  will already bring our data beyond current capabilities. We see this work as a necessary next step, taking the LIFECOUSE project beyond the state-of-the-art once again, with several fundamental implications and broad industrial, societal, and scientific impact.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Regional adjustment strategies to technological change in the context of european integration'.

assistant: **Objectives**

In this project our focus is on provincial regions with labour-intensive industries vulnerable to low-wage competition from within and without Europe. In particular, we will study how local adjustment strategies utilising technological change designed to enhance productivity in labour intensive industries has affected, and will affect in the future, European non-metropolitan regions in terms of their employment potential. By concentrating on labour intensive industries important to our selected regions' employment and competitiveness, we hope to show that local, geographic-specific adjustment strategies have distinctive qualitative and quantitative impacts depending on the particular local institutions (customs, norms, and regulations) that are intended to cope with the pace of economic change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'STRATEGIC PLAN FOR PREVENTION OF REGIONAL WATER RESOURCES CONTAMINATION FROM MINING AND METALLURGICAL INDUSTRIES IN WESTERN BALKAN COUNTRIES' (PREWARC) under Sixth Framework.

assistant: **Objectives**

The Western Balkan Peninsula is rich in natural mineral resources. Among the most important of them are considered the chromite, bauxite, polymetallic complex sulphide, laterite and coal ore deposits, which are used for the production of steel,ferroalloys, aluminium, nickel, base and precious metals. Exploitation of these ore deposits, one of the most dynamic sectors in the Western Balkan region, along with metal extraction that follows cause severe environmental pollution problems in the area, related to contamination of soil and surface-, groundwater.   This project addresses environmental pollution problems associated with mining and metallurgical activities in two Western Balkan countries, in order to develop an Integrated Strategic Plan including proposals for feasible technological improvements in mining and metallurgical industrial activities in the involved area and viable technologies for the management of the industrial wastes ensuring the protection of the natural water resources.   In order to achieve this objective, the project deals with (i) collection and management of information concerning the major mining and metallurgical industries in the involved Western Balkan countries, as well as the extent of the regional water resources contamination and the risks associated with it, (ii) identification of Best Available Technologies that haveto be adopted by the regional mining and metallurgical industries in their production stages, as well as in the related wastes management aiming at waste minimization, prevention of surface-, groundwater contamination and safeguarding the ecosystem of the affected areas (iii) dissemination of the gained knowledge and promotion of the project results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Non-invasive decoding of brain communication patterns to ease motor restoration after stroke' (BCINET) targeting Horizon 2020.

assistant: **Abstract**

Human-computer interfaces are increasingly explored to facilitate interaction with the external world. Brain-computer interfaces (BCIs), bypassing the skeletomuscular system, are particularly promising for assisting paralyzed people in control and communication, but also for boosting neuromotor rehabilitation. Despite their potential, the societal impact of BCIs is dramatically limited by the poor usability in real-life applications. While many solutions have been proposed - from the identification of the best classification algorithm to the type of sensory feedback - the accuracy is still highly variable across subjects and BCIs cannot be used by everyone. Critically, these approaches have implicitly assumed that the user’s intent could be decoded by examining the activity of single brain areas. Today, we know that this is not true as the brain functioning essentially depends on a complex network of interactions between differently specialized areas. The grand challenge of this project is to develop a novel generation of BCIs that integrate the user’s brain network information for enhancing accuracy and usability. Based on this approach, we will experiment innovative BCI prototypes to restore the lost motor functions in patients suffering from stroke. This project relies on a unifying framework that analyses and models brain networks by means of analytical tools derived from graph theory and complex systems science. By recruiting diverse neuroimaging and experimental methods, within a modern computational framework, we aim to i) identify new control features for enhancing BCI accuracy, ii) study the brain dynamics of human learning for improving adaptive BCI architectures, and iii) optimize brain stimulation techniques for boosting BCI skill acquisition. This project c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS  OF A MULTI-MODAL INTERVENTION IN OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE: THE MID-FRAIL STUDY' under Seventh Framework.

assistant: **Concept**

The prevalence of diabetes in people ≥ 65 years approaches 25% (40% of all patients with diabetes are > 65 years). This number will increase 4-fold in people > 70 years in 2050. Diabetes results in a high personal and social health burden, and a significant public health burden in terms of rising healthcare costs. Diabetes is associated with increased functional decline in older people and may explain up to 20% of their excess risk of disability. Our project focuses on the use of interventions to improve functional status and enhance quality of life. This is justified because there has been a lack of intervention studies in this population and improvements in function and well-being may be of more clinical benefit in older patients than attention to metabolic control alone.The MID-FRAIL STUDY is a Phase IIb open randomized clinical trial to evaluate the effectiveness of a multi-modal intervention (optimizing medical management, resistance-based exercise program and educational/nutritional intervention) in 1,704 frail or pre-frail subjects ≥ 70 years with T2D to prevent functional decline and maintain or improve quality of life and its associated costs.This approach is original (both the intervention and outcomes are unique for studies in diabetes), relevant (it concerns 25% of people with diabetes), pertinent and feasible.The project is highly aligned with objectives pursued by two topics of this call: investigator-driven clinical trials in elderly populations (HEALTH 2011 2.2.2-1) and in diabetes complications (HEALTH.2011.2.4.3-1).The study aims to demonstrate a reduction of 20% in that risk, which will mean an annual prevention of around 700,000 incident cases of some disability in old people, with a major impact on global quality of life and financial costs. This is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures' (NOTOX), addressing dissemination and exploitation.

assistant: **Impact**

NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D systems to generate own experimental data to develop and validate predictive mathematical and bioinformatic models characterizing long term toxicity responses. Cellular activities will be monitored continuously by comprehensive analysis of released metabolites, peptides and proteins and by estimation of metabolic fluxes using 13C labelling techniques (fluxomics). At selected time points a part of the cells will be removed for in-depth structural (3D-optical and electron microscopy tomography), transcriptomic, epigenomic, metabolomic, proteomic and fluxomic characterizations. When applicable, cells derived from human stem cells (hESC or iPS) and available human organ simulating systems or even a multi-organ platform developed in SCREENTOX and HEMIBIO will be investigated using developed methods. Together with curated literature and genomic data these toxicological data will be organised in a toxicological database (cooperation with DETECTIVE, COSMOS and TOXBANK). Physiological data including metabolism of test compounds will be incorporated into large-scale computer models that are based on material balancing and kinetics. Various “-omics” data and 3D structural information from organotypic cultures will be integrated using correlative bioinformatic tools. These data also serve as a basis for large scale mathematical models. The overall objectives are to identify cellular and mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Green chemicals and technologies for the wood-to-textile value chain' (GRETE), addressing dissemination and exploitation.

assistant: **Impact**

The GRETE project will tackle the challenges caused by increased global demand for sustainable textile fibres by offering new breakthroughs in the wood-to-textile value chain. The substitution of cotton by man-made cellulose fibres is also necessary because of sustainability issues. Currently the raw material base for the production of man-made cellulose fibres from wood is limited, as only highly processed dissolving grade pulps are used industrially. GRETE will introduce technologies by which paper grade pulps from softwood and hardwood sources can be used as raw material for man-made textile fibres. GRETE will also offer safe and sustainable solvent systems for the production of regenerated cellulose fibres, instead of the present ones which are based on toxic or explosive chemicals.  The developed novel solvents are ionic liquids (IL’s), which will be non-toxic, recyclable and synthesized from low-cost industrially available chemicals. GRETE will also develop innovative technologies for chemical modification and enzymatic pre-treatment of pulps prior to cellulose dissolution. Chemical modification carried out either before or after dissolution and regeneration of pulps will bring chemical functionalities to fibres. The modifications either directly improve fiber properties (e.g. decreased fibrillation, improved fire resistance) or offer an easy route to further fibre processing. Improved dye adsorption and chemical reactivity will offer new options for dyeing and finishing treatments of the fibres, enabling e.g. the creation of a water-scarce end to the textile manufacturing value chain as well as open up the possibility for other targeted and water-scarce finishing treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optical Responses Controlled by DNA Assembly' to be submitted under Seventh Framework.

assistant: **Abstract**

Artificially constructed materials can be designed to shape the propagation of light and can thus exhibit optical characteristics that are not found in nature. With such metamaterials, remarkable optical applications such as cloaking of objects, sensing of molecular environments or the fabrication of perfect lenses that are not bound by optical resolution limits could be realised. However, for metamaterials to operate at visible wavelengths they have to be structured in three dimensions with nanometre precision which currently poses an enormous barrier to their fabrication. By using molecular self-assembly based on the self-recognizing properties of sequence-programmable DNA strands, this barrier will be overcome. After having pioneered the 3D DNA origami method and the creation of DNA-based metamaterials, I propose the following new paths of research:i) Metamaterials that are switchable in electric or magnetic fields and operate at visible or near infrared wavelengths will be designed and produced by DNA self-assembly for the first time. The hypothesis that materials with strong chirality show negative refraction will be tested and optical resonators with dimensions below 100 nm will be generated.ii) The light-shaping characteristics of metal particle helices will be used to detect organic molecules. As most organic molecules are chiral and can be considered as chiral arrangements of multiple dipole elements, it is expected that the organic dipoles couple to the plasmonic dipoles of the metal helices. This in turn will induce changes in the optical activity of the material. In a parallel approach, organic molecules will be used to induce conformational changes in DNA-supported particle assemblies, which will then be detected in their optical response. Both of these fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project '32nd international geological congress - from the mediterranean area toward a global geological renaissance (geology, natural hazards, and cultural heritages)'.

assistant: **Objectives**

The present proposal is addressed to the organisation of the 32nd International Geological Congress (IGC). 32nd IGC will be held 20-28 August 2004 in Florence, Italy, in cooperation with and under the scientific sponsorship of the IUGS. The venue was decided by vote of the Council and ratified by the General Assembly of the 31st Congress that met in Rio de Janeiro in August 2000. The Congress is designed to create a forum for the broad debate of the most significant advances in the geological sciences, to foster new ideas and models for implementing a close interplay between pure science and its applications and to promote discussion of the Congress theme: The Renaissance of Geology: From the Mediterranean area toward a global Geological Renaissance-Geology, Natural Hazards, and Cultural Heritage."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Algorithmics for Metagenomics on Grids' (METAGENOGRIDS), addressing dissemination and exploitation.

assistant: **Impact**

Numerous critical problems in bioinformatics and computational biology are computationally intensive and could benefit from being solved on a computational Grid, that is a network of geographically distributed computers. Most works that combine bioinformatics and Grids focus on biological problems that can be trivially adapted to Grids, staying clear of more complex problems. In this fellowship we propose to address, in an interdisciplinary research, the resolution on Grids of two complex and demanding problems: metagenomics assembly and metagenomics annotation.  Metagenomics is the study of the genomes of an entire community of microbes; metagenomics assembly is the problem of assembling the genome of each of the microbial species in the studied community. The applicant, a Grid computing expert, proposes to work with experts in bioinformatics and experts in Grid computing to design new algorithmic solutions to solve these two metagenomics problems.  In this proposal, the applicant would simultaneously visit for a year, and work with, Prof. Guylaine Poisson's Bioinformatics Lab (BiL) and Prof.  Henri Casanova's Concurrent Research Group (CoRG), both located at the University of Hawai`i at Manoa, USA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Proposal to assess an innovative Immunotherapy, based on a thioredox peptide antigen, in a Phase I Trial for Type-1 Diabetes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Type-1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are gradually destroyed by autoreactive T-cells recognising autoantigens (Auto-Ag) such as GAD65 and insulin. ImCyse, a small SME, has developed a new technology based on short synthetic peptides flanked with a thioredox motif, which silence the pathogenic immune response against several auto-Ag through activation of one auto-Ag specific cytolytic CD4+ T-cells (cCD4). Preclinical work carried out by ImCyse with such peptides in a specific T1D mouse model showed that insulitis, an absolute condition for the development of T1D, is fully prevented (and/or suppressed) upon either active immunisation or passive transfer of GAD65-specific cCD4+ T cells. This was also observed for the prevention of hyperglycaemia.The overall objective of the project is to perform a Phase I clinical study in adult T1D patients, using an immunotherapeutic (ITx) preparation based on the ImCyse technology. Primary objectives are to obtain safety data and information on the immune response, in particular the induction of cCD4+ T-cells and autoimmune responses. Clinical responses will also be monitored.A five-member expert international consortium will conduct: co-ordination, ITx optimisation & GMP process development, manufacturing, toxicity evaluation, regulatory filing, preparation and conduct of the clinical trial and exploitation/dissemination of results.The expectation is to exploit this antigen-specific immune modulation by immunising T1D patients in order to halt disease progression, and also to validate this new technology that could in the long term be applied to other autoimmune diseases. In addition, this project would benefit: patients (better quality of life), the European economy (decreased cost of the disease)