RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Harmonized Evaluation, Certification and Testing of Security Products' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Today physical security equipment and systems are very diverse in technology, concept of operations, application areas and performance. Similar security products are difficult to compare in terms of performance, accuracy, usage, trust and validation of functionality. Currently, there are very few certification procedures in Europe mutually recognized by differentMember States. This leads to fragmentation of the market, as identified in the recent EC Communication on Security Industrial Policy, with negative impacts on both suppliers and users.HECTOS will study if and how existing evaluation and certification schemes used in other areas including Common Criteria, New Legislative Framework, ECAC CEP, CertAlarm etc. could be used and possibly further developed/enhanced/adapted/integrated as a general approach for the assessment and certification of products used for physical security of people and infrastructure. As well as mechanisms to independently evaluate security product performance, on a scientifically valid and statistically reliable basis, the project will consider ethical and privacy requirements and regulatory compliance. The approach will be validated through experiments using two different product groups as case studies: weapons and explosives detection systems (outside of aviation security) and biometric recognition.  The project will develop a roadmap for the development of new harmonized certification schemes and provide standardization bodies with proposals for new work items.HECTOS will establish expert and user groups from industry, regulators, standards bodies and end-users in order to gather requirements, seek input on direction and priorities, communicate and build consensus in the results of the work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'On the evolution of fleshy fruits: An integrative test to assess the relative role of intrinsic and extrinsic factors in shaping fruit type' (FRUITFUL).

assistant: **Innovation**

A trip to a grocery store exposes us to an outstanding diversity of fruits. While this variety was influenced by human selection during plant domestication, it mainly reflects strategies of seed dispersal that evolved over millions of years. Despite the huge variation in fruit color, shape, and size, common patterns can still be identified, especially the repeated evolution of fleshy fruits (e.g. olives, apples, tomatoes). Though this pattern is well observed, we are still exploring the role of different factors and their selective pressures. These can be intrinsic, as evolution of inherited genes determining fruit traits, or extrinsic, as the environment. To date, studies have focused on one or two major factors at a time, but their relative contributions requires an integrative analysis.FRUITFUL will dissect the evolution of fleshy fruits in the olive family. Oleaceae is the ideal study subject here because it presents a natural comparative set-up for fruit evolution: multiple lineages that independently evolved fleshy fruits; species living in a variety of environments; and diverse seed dispersers. Further, several genomes and transcriptomes of Oleaceae were recently released.In this project, I will: (1) identify independent transitions to fleshy fruit within a comprehensive phylogenetic framework of Oleaceae; (2) use phylogenomic approaches to analyze representative genes in species with fleshy or dry fruits, and test for switches in selective pressures in relation to trait transitions; (3) estimate the historical biogeography of the family, along with current environmental preferences of species, and their seed dispersers; and finally, (4) integrate all results in models of causal relationships, and identify direct and indirect effects, and their magnitudes, among
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Sequencing Glycosaminoglycans'.

assistant: **Innovation**

The primary objective of this research proposal is to fully develop and commercialise a novel technology. Is anticipated that a major application of this technology will be in the area of the neurosciences so a shared cost demonstration project application in this area will also be prepared to demonstrate the technology to a partnership of both industrial and academic end users. The technology, which was developed in laboratories of the Cancer Research Campaign in England, has now been licensed by the SME Oxford GlycoSciences. This grant would enable market research, product development, the commerical launch of reagents and kits as well as the preparation of the shared cost demonstration project. The research project would allow the application of this novel technology to an important area of biotechnology in the neurosciences which would be pursued as a shared cost demonstration project in Biotechnology (call for proposals June 1997).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Molecular imaging and targeted therapy of the aggressive phenotype: development of uPAR theranostics for cancer patients'.

assistant: **Objectives**

For practice of personalized medicine in cancer, non-invasive tools for diagnosing at the molecular level are needed. Molecular imaging methods are capable of this while at the same time circumventing sampling error as the whole tumor burden is evaluated.We recently developed and performed the first-ever clinical PET scan of uPAR, a proteolytic system known to be strongly associated with metastatic potential in most cancer forms. We believe this new concept of uPAR-PET is a major breakthrough and has the potential to become one of the most used PET tracers as it fulfils unmet needs in prostate and breast cancer. Based on this, together with additional proof-of-concept data we obtained on targeting uPAR for optical imaging and radionuclide therapy, we now plan to develop and take into patients these new technologies for improved outcome.Specific aims are to develop and translate into human use:1. A PET uPAR imaging ligand platform for visualization of the aggressive phenotype and risk-stratification to be used in tailoring therapy, e.g. in prostate cancer to decide whether prostatectomy is necessary.2. uPAR-PET combined with simultaneous 13C-hyperpolarized pyruvate MRSI (Warburg effect). This will increase prognostic power, refine tumor phenotyping and thereby allow for better tailoring of therapy and early prediction of treatment response.3. A uPAR optical imaging technology for guiding removal of cancer tissue during surgery. This will help delineate cancer tissue for removal while leaving healthy tissue behind. We expect better outcome with removal of less tissue.4. Selective radionuclide therapies targeting uPAR positive, invasive cancer cells using β or α emitters. Dose planning will be performed using uPAR-PET imaging. This image-therapy pairing is also known as th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural and functional analysis of virus specific TCR-pMHC recognition' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The proposed research plans to understand the relationship between structural requirements for TCR/peptide/MHC interactions and their influence on TCR repertoire diversity given it has been reported that increased T cell repertoire diversity correlates with increased resistance to viral infection. While the structural characteristics of TCR/peptide/MHC interactions can be elucidated, a large question that remains is how these factors influence the function of virus-specific CTL generated after infection.   This proposal aims to first study the molecular interactions that define specific TCR recognition of both DbNP366 and DbPA224 complexes (respiratory infection of C57BL/6J (H-2b) mice with influenza A viruses induces CD8+ T cell responses specific for epitopes derived from nucleoprotein amino acid 366-374 and acidic polymerase amino acid 224-233 with structural and functional differences). The second aim utilises a retroviral transduction system to ectopically express TCRs of known specificity. This will facilitate the analysis of functional characteristics of these transduced T cells after infection. In this way, this proposal will link the structural aspects of TCR recognition of peptide/MHC complexes and the in vivo consequences these interactions have on the responding T cell repertoire. These studies will provide a rationale for vaccine design human viral pathogens such as HIV, Hepatitis C and Influenza A virus.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'e-Intervention Enhancing Mental Health in Adolescents'.

assistant: **Innovation**

The e-Intervention Enhancing Mental Health in Adolescents project, IMPROVA, will co-design, pilot, evaluate, and facilitate the upscaling of a modular eHealth intervention platform that aims to improve mental health and well-being, early detect mental health problems and prevent common mental disorders in adolescents. The IMPROVA consortium includes an international and inter-disciplinary group of researchers and practitioners from health, educational and social sciences in addition to computer scientists, a teacher association and policymakers. The IMPROVA online platform will be co-created with stakeholder groups, including adolescents, parents, teachers, school health professionals and policymakers based on materials already designed and tested in more than 20 projects carried out by the consortium members. The platform will include components for adolescents, parents, teachers, and school health professionals in complementary and synergistic modules. After a series of pilot testing sessions, IMPROVA will be implemented by conducting a randomized Stepped Wedge Trial Design (SWTD) in secondary education schools randomly selected in four countries (France, Germany, Romania and Spain), including 12,800 adolescents. Effectiveness, cost-effectiveness and cost-benefit will be calculated. Using implementation science methodology, IMPROVA will co-design with policymakers and stakeholders transferable evidence-based practices, methodologies and guidance for upscaling of the IMPROVA platform. IMPROVA aims to provide stakeholders and policy makers with an evidence-based, innovative, large-scale, comprehensive intervention, and a scale-up plan to promote mental health and prevent mental disorders in adolescents; empower adolescents and families to make better decisions regarding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Caste-specific gene expression in the fire ant, Solenopsis invicta', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Societies of ants, bees, and wasps achieve a highly efficient division of labour by matching the morphology, physiology, life-history, and behaviour of each female to her role in the colony. Females thus occur in distinct castes (e.g. workers and queens). Castes are an example of polyphenism: the caste fate of developing larvae does not depend on their genotype, but is determined by their environment. Therefore, caste differentiation must involve the differential expression of genes that are shared by all castes. Identifying caste-specific patterns of gene expression thus offers a special opportunity to study the generation of adaptive morphological variation by a fundamental biological process, and is the key to profound understanding of the evolution of sociality. Because of the recent development of new methods (especially microarrays) for identifying differentially expressed genes, a burst of research on caste differentiation is predicted. I propose to study caste-specific gene expression in the fire ant, Solenopsis invicta, with a large ( and gt;20,000 clones) spotted cDNA microarray that was recently developed, sequenced, and annotated at the prospective host institute, the group of Prof. L. Keller at the University of Lausanne. S. invicta is the second social insect species (after the honeybee) and the first ant species for which a large microarray has become available. I will study differential gene expression at three levels: in queen vs. worker larvae; in minor vs. major worker larvae; and in the brai n of (equally old) foragers and brood care workers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Integrated Infrastructure Initiative HYDRALAB-III'.

assistant: **Objectives**

HYDRALAB-III is an Integrated Infrastructure Initiative with the objective to optimise the important position of laboratory experiments in the field of Hydraulics, Geophysical Hydrodynamics, Environmental Fluid Dynamics, Ship Dynamics and Ice Engineering (HyGESI). HYDRALAB-III will implement this by a coordinated program of transnational access, joint research activities and networking activities, destined to improve, refine and harmonise the use of the available high-quality facilities and measuring methods in these fields.HYDRALAB-III will improve the performance of unique experimental facilities through a balanced combination of activities:- Networking activities (4), in which HYDRALAB-III will be managed, knowledge will be disseminated to the HyGESI community and the use of high-quality facilities and measuring methods will be improved.- Complementary Access activities (9) to 22 experimental facilities throughout Europe. Enabling researchers to carry out research in facilities to which, if it wasn't for this programme, they normally would have no access to.- Two mutually focussed Joint Research Activities on:A. improving methods of modelling the interactions between beaches and structures by developing composite modelling techniquesB. innovating instruments and good-practice protocols for mobile bed tests HYDRALAB-III also specifically focuses on the involvement of females and young researchers.By doing so, HYDRALAB-III will have a long-term integrating effect on the operation and interaction of the infrastructures in HyGESI, with the perspective of establishing a series of virtual European Laboratories, thus contributing to the structuring of the European Research Area (ERA).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Fluid flow and heat transfer within the rotating internal cooling air systems of gas turbines (2) (icas-gt2)'.

assistant: **Objectives**

The fuel efficiency of gas turbine engines for aircraft propulsion and electrical power generation must continue to improve if the European gas turbine industry is to remain competitive. Gas turbine internal air systems are required for cooling highly stressed components and for preventing the ingress of hot annulus gas, but these system cost 6% engine specific fuel consumption (SFC). This industry led project targets a 1% reduction in SFC through internal air system optimisation. Rotating fluid flow and heat transfer data will be generated from engine representative experiments at the partner universities. This data will be used by the ten industrial partners to validate their predictive capability, and to optimise air system designs. Validated design tools will be exploited to reduce new product time to market. The optimised designs will be exploited to reduce SFC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of a fuel flexible and highly efficient ultra low emission residential-scale boiler with coupled heat recuperation based on flue gas condensation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The project aims at the development of a new fuel flexible and highly efficient residential biomass heating technology (20 - 130 kW). It is based on the successful UleWIN wood chip and pellet boiler concept consisting of a fixed-bed updraft gasifier directly coupled with a Low-NOx gas burner and a hot water boiler, which shall be further developed for fuel flexible operation (utilisation of forest residues, SRF, miscanthus, olive stones, nut shells and agro-pellets). Moreover, a compact flue gas condensation system with integrated condensate neutralisation, also capable to operate with highly acidic flue gases from agricultural fuel combustion, shall be developed to increase the efficiency of the whole system up to 110% (related to the fuel NCV). An advanced control system as well as measures for improved system integration shall additionally increase the annual utilisation rate up to 95%. It is expected to achieve at the end of the project a TRL of 5.These objectives are very relevant to the work programme since they focus on highly efficient and fuel flexible residential heat production at almost zero CO and OGC emissions, by 50% reduced NOx emissions (compared with conventional boilers) as well as ultra-low PM emissions below 13 mg/MJ (even when utilising K-rich fuels). Since this shall be reached by primary measures only, fuel flexible heat generation will be possible at reduced heat generation costs in comparison to present heating systems.To fulfil these goals an overall methodology shall be applied which is divided into a technology development part (based on process simulations, computer aided design of the single units, test plant construction, performance and evaluation of test runs) as well as a technology assessment part covering risk, techno-economic, envir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Developmental neurotoxicity of polybrominated diphenyl ethers: mechanisms and effects' under Fifth Framework.

assistant: **Concept**

The goal of the proposal is to elucidate the effects of developmental exposure of animals to flame retardants Polybrominated Diphenyle Ethers (PBDE) on the central nervous system (CNS). Epidemiological studies indicate a marked increase of PBDE levels in breast milk. In contrast, effects of PBDEs on the developing CNS are largely unknown. Therefore, the aims of the proposal are: to assess several neurobehavioural endpoints after perinatal treatment of animals for characterization of of possible impairments; To relate neurobehavioral effects to electrophysiological effects in the different brain areas; To compare perinatal with adult exposure in order to examine if the developing CNS is particularly susceptible to PBDEs; To compare different animal species for generalization of the findings; and to characterize mechanisms of PBDE neural toxicity at cellular and molecular levels; to examine if exposure alters sexual differentiation of the brain. PBDE effects will be compared to PCB-induced effects.