RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Strongly Enhanced Sensitivity EPR through Bimodal Resonators and Quantum-Limited Amplifiers' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Electron paramagnetic resonance (EPR) is a powerful tool employed across various disciplines including structural biology, chemistry, physics, material science, and many others. It provides important and unique information on a local electron spin environment, electronic properties and dynamics of various paramagnetic centers. However, a relatively low sensitivity of this method often limits the range and type of systems that can be studied. Thus, major advancements in EPR sensitivity are crucial to significantly broaden its applicability, encompassing new and highly relevant systems such as single cells.The Strongly Enhanced Sensitivity EPR through Bimodal Resonators and Quantum-Limited Amplifiers (Strong-ESPRESSO) project will ignite a revolution in EPR by employing sophisticated bimodal microwave resonators and intricate ways of noise reduction in tandem with novel microwave amplifiers developed for quantum technologies. We will achieve this by first delivering a new generation of EPR cryoprobeheads, which will utilize the orthogonal-field bimodal cavities, allowing to reach the sensitivity limit of these instruments. Secondly, we will transfer the bimodal cavity concept to planar superconducting microresonators, enabling the employment of these tools to study tiny (pL volume) samples of typical fast-decohering spin systems (e.g. protein droplets). Finally, we will develop an ultra-sensitive EPR setup based on the radiative cooling effect of the bimodal resonators and recent advances in the quantum-limited microwave amplifiers. This revolutionary new setup is expected to provide a ground-breaking 5000x reduction in the EPR measurement time, simultaneously preserving compatibility with ordinary EPR experiments and samples. Throughout the project, we will immediately a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CIVITAS ELAN Mobilising citizens for vital cities  Ljubljana - Gent - Zagreb - Brno - Porto', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

CIVITAS-ELAN is a large and ambitious project of great strategic importance to its project partners and funding institutions. The mayors of the cities of Ljubljana, Gent, Zagreb, Brno and Porto have agreed to a common mission statement “To ‘mobilise’ our citizens by developing with their support clean mobility solutions for vital cities, ensuring health and access for all. The five cities intend to cooperate on the basis of a clear set of common objectives, based on the principle of “putting the citizen first”. For each of the CIVITAS policy fields a common set of objectives and project goals has been agreed, and the cities have developed a programme of in total sixty-nine measures, which are described in detail, including concrete targets.The focus on citizen participation has been deeply built into the workplan, also several NGOs are part of the project consortium.The ELAN cities are representative of a growing number of dynamic, mainly medium-sized national or  regional centres with strong cultural background. The planning of the project is mature with detailed timetable, resources and organisational structures. The project consortium is very experienced, some partners were involved in CIVITAS 1 and 2 from various perspectives. As requested in the call, a city from New Member States (NMS) (Ljubljana) is the project coordinator and a learning city (Brno) is also from a NMS. A further leading city (Zagreb) is from a candidate country thus bringing the CIVITAS initiative in the enlargement prospect. The workplan addresses topics of specific interest to cities in the NMS. Through CIVITAS-ELAN three new countries, Portugal, Croatia and Belgium will be put on the CIVITAS map as ELAN cities are committed to become ambassadors in their countries.As a policy-driven project, C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Roles of G-quadruplexes in Kaposi’s sarcoma-associated herpesvirus latent REplication' to be submitted under Horizon Europe.

assistant: **Abstract**

Kaposis sarcoma-associated herpesvirus (KSHV) is a widespread oncogenic virus, whose infection can cause Kaposis sarcoma, an incurable cancer frequent in immunocompromised individuals. Similar to other herpesviruses, KSHV establishes a latent infection in the host, characterized by lifelong persistence of the viral genome. Necessary and sufficient for latent infection are the virally expressed latency-associated nuclear antigen (LANA) and highly repetitive GC-rich sequences on the viral genome, named terminal repeats (TRs). While several studies have uncovered the importance of LANA in promoting KSHV DNA replication and segregation during latency, the essential role of the TRs remains poorly understood. In particular, the GC-rich regions contained in the TRs have been speculated to fold into G-quadruplexes (G4), secondary DNA structures that can function as replication barriers, but their roles remain elusive. A deep mechanistic understanding of the ways KSHV maintains itself in latency would be crucial to uncover a way to eradicate the virus from the infected cells, before the onset of Kaposis sarcoma, but this knowledge is missing, mainly due to the methodological limitations of investigating KSHV latent replication solely in cells. With this proposal, in aim to take advantage of the Xenopus laevis egg extract in vitro system to go beyond such limitations and to gain mechanistic insight in the role of G4s in the latency of KSHV. By combining my extensive expertise in the field of DNA replication with the deep knowledge of Prof. Sara Richter at the University of Padua in secondary DNA structures in viral genomes, I aim at mechanistically defining the strategies adopted by KSHV to maintain itself in latency and at identifying approaches to prevent viral maintenance in K
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Links between warming Arctic and climate extremes in northern Eurasia'.

assistant: **Innovation**

During last three decades, the Arctic has warmed faster than rest of the planet going through unprecedented physical changes as manifested by the record low sea-ice and snow areas in summer. Impacts of these changes on weather and climate outside the Arctic region, such as in northern Eurasia, might be substantial because the Arctic is an integral part of the global climate system. Potentially associated with Arctic warming, an increased occurrence of extreme events, such as heat waves, exceptionally cold winters and flooding, often of unprecedented strength and duration, has already been observed in the Northern Hemisphere during the last decade.Our main motivation is to reduce the potential damage by extreme climate events. For this, we propose to investigate teleconnections linking the ocean and land surface characteristics to the occurrence of extremes.  We hypothesise that Arctic warming is affecting Eurasian climate extremes by teleconnections along with other regions, such as the North Atlantic and Pacific. However, our understanding of mechanisms of teleconnections is incomplete due to imperfect models and sparse observations. To address this gap, we will compare observations and climate model output and select the most realistic models in terms of their ability to represent teleconnections. To investigate mechanisms, we configure and execute climate model simulations. Results of our work will be used to improve models' prediction skill and to reduce uncertainties related to estimates of changes in climate extremes in Eurasia.The experienced researcher, Prof. Uotila, has an extensive experience in climatological research focused on the Southern Hemisphere using methods closely related to the ones proposed for this work. His supervisor, Prof. Vihma, is a leading
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Network of the INCO-NCPs'.

assistant: **Concept**

The INCONTACT project aims at the development of platform for stimulating closer cooperation among INCO National Contact Points. Within the framework of this closer cooperation, INCO NCPs will work together to effect a substantial improvement in the overall quality of NCP services in the field of International Cooperation. The positive effect of these efforts will not be limited to the NCP network alone. The international research community will ultimately benefit from the heightened level of service offered by the network. Individual researchers will profit from higher quality services and information, and the establishment of a more consistent level of NCP services across Europe will contribute to greater transparency of the research funding for ICP participants.    Activities including 3 awareness and training workshops in ICPC countries (Mexico, Russia, South Africa), exchange of experience, good practice, training for inexperienced European NCPs will strengthen the overall capacity of INCO NCPs and provide for more coherence of the support activities offered. In addition an Online Encyclopaedia on International Cooperation compiling all relevant information on International Cooperation activities in FP7 will be developed. The online encyclopaedia will work according to the principles of the Wikipedia online encyclopaedia allowing the interaction and the collection of best practices from all the INCO NCPs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional analysis of TSPAN14 as a genetic risk factor for Alzheimer’s disease' (TSPAN14-AD) targeting Horizon Europe.

assistant: **Abstract**

Alzheimer’s disease (AD) is the most prevalent deadly neurodegenerative disorder for which no effective treatment exists as of today. Therefore, there is an urgent need to better understand the molecular mechanisms behind AD in order to develop more effective treatments against this complex disease. Recent genetic findings have highlighted several AD-associated genes, many of which are preferentially expressed in microglia in the brain. One of these is tetraspanin 14 (TSPAN14), whose physiological function in the brain is not yet understood. Recent studies suggest that TSPAN14 may act as a functional regulator of ADAM10, a transmembrane protease that cleaves multiple substrates in the brain including the AD-associated protein TREM2. Full-length TREM2 is essential for the phagocytic activity of microglia and its cleavage by ADAM10 results in loss of function. The central aim of the TSPAN14-AD project is to understand how TSPAN14 controls molecular pathways involved in AD, by focusing on proteolysis and function of TREM2. Specifically, we hypothesize that TSPAN14 increases AD risk by modulation of TREM2 cleavage and microglial phagocytosis. The 3 objectives of TSPAN14-AD are to: (1) determine whether AD-protective TSPAN14 alternative splicing variants result in reduced TSPAN14 protein expression; (2) elucidate whether reduced TSPAN14 expression results in decreased ADAM10 cell surface expression; (3) assess whether loss of TSPAN14 reduces TREM2 cleavage and enhances phagocytic activity of microglia. To accomplish this, a combination of biochemical, molecular, and proteomic techniques will be used within both in vitro and in vivo models, including human induced pluripotent stem cell (iPSC)-derived microglia and post-mortem human brain tissue. Outcomes of the project have t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High efficiency silicon solar cells concentrator ('HISICON')' (HISICON), addressing dissemination and exploitation.

assistant: **Impact**

Objectives and problem to be solved: The objective of the project is to develop cost effective photovoltaic systems to contribute to the EC strategy of doubling the share of Renewable Energy in the energy mix. Photovoltaic systems working at high concentration are expected to be able to produce electricity at prices comparable to the existing prices. Presently developed concentration systems use expensive Saga cells. Concentration systems using silicon cells produced in conventional silicon foundries are expected to be more cost effective than those based on expensive Saga cells. Description of work: The objective of the project is to develop a low cost X500 photovoltaic concentration system. The system is based on the concept of two stages concentration and the use of silicon cells: · the light is focussed on the silicon cell by a primary concentrator having a concentration ratio of typically X100 to X300· a silicon cell having both n and p grids on the face through which light is entering is placed at the focus of the primary concentrator· an array of micro lenses placed on the silicon cell focuses the light between the grids of· the cell, leading to an overall concentration ratio of typically X500. This concept allows a maximum collection of the light and optimum working conditions for the silicon cell. The target specifications for the system are:· 15% efficient encapsulated modules, at a NOCT not higher than 50°C above ambient.· A kip system demonstrator mounted on a two axis tracking system will me manufactured and tested. Expected Results and Exploitation Plans: The aim of this project is to develop a photovoltaic system capable of producing electricity at prices, comparable to those of grid electricity, i.e. below 0.1 Euro/kWh. Target applications for these syst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Support for participation by young scientists at the eaap annual meeting 1-4 september, 2002' (EAAP-SCHOL-2002).

assistant: **Innovation**

This Proposal is to enable young animal scientists from Central and East European associate States with FP5 and 'Third States' of the Mediterranean Partnership associated with FP5 to participate at the Scientific Sessions of the Annual Meeting of the EAAP to be held at Cairo, Egypt, on 1-4 September 2002. EAAP operates a Scholarship Programme to support young scientists to attend and present a paper, to attend the conference sessions, symposia and roundtable discussions, and also to attend a course on Writing and Presenting Scientific Papers. The conference will have special relevance to the Mediterranean basin countries. EAAP wishes to increase the number of scholarships given, with particular emphasis on young scientists from the CEEC and Mediterranean basin states that are located geographically in the area where the Annual Meeting will be held.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nanocomposites for Piston/Liner Systems', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Self Lubricating Metal and Ceramic Matrix Nan Composites are materials consisting of a metal or harts off matrix with dispersed self-lubricating Nan particles. Fun Piston/Liner systems the matrix may be a refractory metal like tungsten, molybdenum and chromium or a carbide or nitride of these metals or titanium, etc. The solid lubricant would be graphite, disulfide, h-BN, etc. SLMCMNCs have so far never been synthesized and there exists no process technology frothier synthesis. Self-lubricating Nan composites with a lubricant matrix (DLC) and carbide (WC, B4C) inclusions are state of the art since 15 years. They are produced by a P&CVD method on a large scale. SelflubricatingMetal and Ceramic Matrix Micro Composites are state of the art since at least a century. They are produced by filling (Sic/C), sintering and casting (e.g. grey cast iron, Pub/PTFE, Cusp, Alan, etc), galvanic & electrolessdeposition (Ni/PFE), plasma spraying (alloy + Moss, PTFE). They are used for gliding seals. The technologies used for self-lubricating microcomp.can not be used for non-com. for workers hygiene reasons, since they would involve handling of large quantities of powders of nanosizedparticles, which are a clear health risk. The state of the art PVD or CVD methods have failed so far in producing such non-com. (with the exception of Asian), since these technologies usually do not produce bi-phasematerials. In NAPILIS project two solutions will be explored:1.sputter deposition process, combining the selection of inappropriate metallurgy with the use of extremely short (mess) intense heat spikes to promote the appropriate segregation.2. In a combined arc+ sputter process, strong particle-particle emission from a graphite source will be obtained. SLMCMNCs will be then applied to Piston/Line
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating eukaryotic replisome dynamics at the single molecule level' (2014-2020).

assistant: **Concept**

For cells to reproduce, an accurate duplicate of the genome must be created. This is no small task. The genetic information stored in each cell consists of ~6 billion pairs of nucleobases (base pairs, bp) assembled as a polymer 2 metres long and 2 nanometres in diameter, with the structural form of a double helix. For a mammalian cell to divide, this deoxyribonucleic acid (DNA) must be copied in a time frame on the order of 1 day, or ~70,000bp a second. DNA replication is common to all 3 domains of life, bacteria, archaea and eukarya and is accomplished by a complex of proteins. This proposal brings together a researcher of great proficiency in single molecule methods and multidisciplinary research with the Single Molecule Imaging group at the London Research Institute, one of the world leading centres in DNA replication. Combined, we will build unique instruments and develop single molecule assays to understand the molecular gymnastics of DNA replication in eukaryotes. We will elucidate rates of DNA unwinding by eukaryotic helicases and establish enhancements by association with other proteins. We will also study replisome dynamics by observing synthesis of DNA on custom templates in real time. This will allow detection of replication loops and stalling that may occur. We will also examine the mechanism of lesion bypass. The insight gained is impossible with classical biochemical techniques, as individual replisomes are observed in real time rather than measuring an average of a population. Our methods will reveal heterogeneities and obtain precise quantitative details of the dynamics. Features such as pauses and back slips will enable the study of intermediate states and conformational changes linked to replisome dynamics. This proposal will satisfy academic curiosity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Chaos and thermal effects in black hole interactions' (BlackHoleChaos), addressing dissemination and exploitation.

assistant: **Impact**

The understanding of the microscopic origin of chaos and thermal effects in the physics of black holes is very challenging. Such fundamental aspects seem to be intimately connected, but a microscopic analytical description of their interplay is still missing. The quantum gravity description of these aspects could help clarify their microscopic interconnection. The project I propose has the ambition to probe black hole states through highly excited string and coherent string states, providing a quantum microscopic description of chaos, thermal effects and information theory. The main observables are scattering and decay processes. The research programme contains the following parts. First, a general strategy will be developed to measure, and analytically control, chaos in physical processes involving black holes, such as black hole decays and black hole Compton scattering. In particular, a quantitative measure of chaos will be introduced using Random Matrix Theory techniques and the relative Lyapunov exponents will be computed. Second, in order to study thermal effects in black hole processes, the triggering of the thermalization phase driven by chaos will be investigated. Finally, the project will consider the following direct applications. The first one will be the study of chaotic signatures in wave forms and quasi-normal modes of gravitational and electro-magnetic waves; the second will concern the realization of black hole horizons in terms of highly excited string and coherent string form factors.


**Keywords:** Black holes, thermalization, chaos, string theory, string excited states, string scattering