RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unlocking the Potential of Dredged Sediments : Towards Sustainable Geopolymers for Green Construction' (UP-RISE).

assistant: **Innovation**

Climate change poses a global challenge, and the production of cement contributes significantly to greenhouse gas emissions (GHG) by 58%. This project is, therefore, poised to revolutionize the industry by developing an innovative, eco-friendly cement using dredged materials (DMs) as precursors to produce greener geopolymers. The latter are synthesized by mixing materials rich in aluminosilicates with an alkaline solution. The GHG of geopolymer concrete is ~73% and ~46% less than ordinary Portland cement (OPC) concrete, respectively. Geopolymers exhibit noticeably improved mechanical properties compared to OPC concrete and have been shown to have better resistance to acid attacks, high temperatures, and fire. However, the production of large quantities of geopolymer concrete is limited due to the declining availability of fly ash worldwide. Dredged sediments have been identified as a potential source of silica and alumina. This project sets out to establish the foundational science needed to transform DMs into materials suitable for structural applications, thus pioneering a sustainable path to CO2 reduction. This study will foster the adoption of these by-products in sustainable infrastructure development and create a roadmap for producing DM-based geopolymers. The research, led by me, Dr. Amine el Mahdi Safhi, under the mentorship of Dr. Mahdi Kioumarsi and Dr. Shima Pilehvar at stfold University College (Hi) in Norway, will bolster my skills in materials and structural engineering, preparing me for an expansive academic career. The project is an international endeavor, with the collaboration of Dr. Ahmed Soliman from Concordia University (Canada) and industrial partner NETICS (Netherlands). Our vision is to turn an environmental challenge into an opportunity for sust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Roles of maize PIP2 aquaporins in the structural organization of the cell'.

assistant: **Objectives**

Plasma membrane (PM) Intrinsic Proteins (PIPs) are aquaporins that facilitate the diffusion of water through cell membranes. By regulating PIP activity, plant cells adjust water permeability rapidly and reversibly. PIP PM lateral diffusion is affected by the cell wall and actin. Also, PM-located PIPs interact with VAP27s at the endoplasmic reticulum (ER)–PM contact sites (EPCS). Evidence suggests that PIPs get organized in interaction with other cellular structures. However, the functional relevance of these interactions has not been extensively studied. The PIPContactSites project's main goal is to understand whether ZmPIP2s mediate PM interaction with other cellular structures (ER, cytoskeleton) and elucidate the physiological relevance of the contact sites under salt stress conditions. Our hypothesis is that PIP2 interactions on EPCS and with the cytoskeleton facilitate an efficient response to stimuli by participating in the structural organization of the cell. Our strategy integrates cutting-edge technologies for genome edition (CRISPR/Cas9) and real-time monitoring of interactions (split Fluorescence-Activating and absorption Shifting Tag) with advanced microscopy technologies (i.e., confocal super-resolution and Correlative Light and Electron Microscopy). The originality of this project is to consider PIPs as multifunctional proteins: channels and scaffold proteins. The MSCA fellowship, the great intellectual environment, the infrastructure and the administrative support at the LIBST-UCLouvain, the research and project managing experience of Prof. Chaumont, and my background in molecular biology will synergistically promote the success of the project. The host group will benefit from hosting an independent, creative, and highly skilled scientist. And I will gain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A POINT-OF-CARE BIOCHIP FOR HIV MONITORING IN THE DEVELOPING WORLD'.

assistant: **Innovation**

HIV/AIDS is one of the most destructive pandemics in human history, responsible for more than 25 million deaths. More than 30 million people live with limited or no access to therapeutic treatments, mainly due to the high cost of highly active antiretroviral therapies (HAART) and current diagnostic tests as well as due to the lack of basic infrastructure (e.g. lack of electricity, no trained personnel) that can support these tests. The need for innovative, inexpensive diagnostic instrumentation technology that can be used in resource-limited settings is immediate.While programs that offer free HAART are being implemented in resource-limited settings, no diagnostic tests are available for evaluating the efficacy of HAART provided for the reasons mentioned above. Efficient management of HAART requires monitoring the course of HIV infection over time. The World Health Organization (WHO) recommends the CD4 T-cell count test for monitoring the clinical status of HIV individuals in resource-limited settings.We propose to develop a portable, inexpensive, MEMS (MicroElectroMechanical Systems)-based, imaging system for counting the absolute number of CD4 cells from 1 l of whole blood. We use the term ‘imaging system’ to denote the different approach we follow for counting CD4 cells: rather the reading one by one singles cells (as it is done with flow cytometry), our system can image simultaneously thousands of individual cells, pre-assembled on the surface of a biochip.  Although the proposed imaging system can replace current expensive cell counting instrumentation, our goal is to develop a system that can reach the end-user wherever limited infrastructure is present and no access to a hospital or clinic is possible. Such technology will not only enable to monitor the efficacy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'UNA Europa, an alliance of universities FOR the emergence of talent and the development of research CAREERs' under Horizon 2020.

assistant: **Concept**

Universidad Complutense de Madrid (UCM), one of the top ranked Universities in Spain, supports Post Doctorates through its own talent attraction programme (0,5M€/year) and co-funds 50% of Regional programmes (0.5M€/year). UCM is a well-positioned University at National and EU level, but expanding the funding and territorial scope of these initiatives will allow UCM and the Region to become even more attractive to outside talent. UNI4CAREER aims at mobilizing 7M€ in the Region (over doubling current funding), through a multiannual fellowship programme (60 months) that will attract 40 experienced researchers in 2 international calls (20 researchers / call). The fellows will incorporate into one of 94 UCM´s excellence groups on 4 knowledge areas: humanities, health, social and experimental sciences. UNA4CAREER leverages on UNA EUROPA ALLIANCE inspired by, and contributing to, EC EUROPEAN UNIVERSITIES INITIATIVE: UCM plus 5 top EU universities from Italy, France, Belgium, Germany and Poland, that will be Partner Organisations (PO) offering secondment positions, being all committed with HRS4R (4 out of 6 members, including UCM, awarded).UNA4CAREER, as an open network enabling 40 researchers to combine their work in an INTERNATIONAL (6 countries), CROSS-SECTORAL (possibility to interact with over 500 actors through the UNA Europa Alliance) and INTERDISCIPLINARY (4 scientific areas) framework, will definitely help spreading the best practices of the Marie Skłodowska-Curie actions. UNA4CAREER will allow the fellows to EXPAND their SKILLS in order to improve their employability in both the academic and non-academic sectors, through SECONDMENTS (60 months in Academic and 30 months in non-Academic entities are estimated). UNA4CAREER will also encourage researchers to PURSUE A CARE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Flexible Strategy for Stapling and De-Stapling of Unprotected Peptides' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cyclic (stapled) peptides often possess superior biological activity compared to their linear counterparts and are more attractive leads in drug development. This is for several reasons: conformational rigidity (enhanced binding to target molecules and receptor selectivity), resistance to degradation by peptidases (increased stability and potency), and greater cell permeability. Reliable strategies for peptide stapling are therefore in high demand, especially if cyclizations are reversible under certain controllable conditions. The reason is that a linear peptide can be biologically more active. If de-stapling can be triggered by an intracellular signal, then once the cyclic peptide has entered the cytosol, it can be converted to its more active acyclic form.We propose to develop a robust, practical, and broadly applicable catalytic method for stabling of peptides. Cyclizations, which will be promoted by inexpensive and easily available Cu(I) catalysts, are inspired by recent findings by the host group in Strasbourg. The Hoveyda group has shown that a highly functional group tolerant catalytic click reaction can be used to link a drug-bound allene to a ketone that is bound to unprotected penetratin, a cell-penetrating peptide (CPP). The process was completed in just 3-5 hours in aqueous media and at ambient temperature. Also inspired by the recent discoveries in the host group, de-stapling will be triggered by a reactive oxygen species (ROS) and specifically H2O2, higher concentration of which have been shown to signal the onset of diseases such as cancer and diabetes.The results of these studies are expected to have an immediate impact on catalytic chemical synthesis, aiding in the elucidation of biological mechanisms and accelerating drug development and discovery. Ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Citrus breeding for efficient water and nutrient use.' (CIBEWU).

assistant: **Concept**

Mediterranean citriculture face up to an increasing combination of biotic (Citrus tristeza virus (CTV) /phytophthora) and abiotic stresses (salinity /alkalinity). Most of these constraints should be individually managed by the rootstock choice. However, s pread of CTV all over the Med. Basin will soon prohibit the current use of the traditional sour orange rootstock, that provide adequate tolerance to salinity and alkalinity. Therefore, there is an urgent need to select new citrus rootstocks. All the requi red traits are present in citrus germplasm but the complexity of citrus biology and genetic make it difficult to combine them through traditional breeding.The project proposes to enhance the efficiency of citrus germplasm for rootstock breeding under two main breeding strategies: sexual recombination and somatic hybridisation. Knowledge and methodologies will be developed by combining physiological, genomic, genetic and biotechnological approaches. Training and methodology transfer to the end users are i mportant component of the project. The project will focus on tolerance to salinity and tolerance to iron deficiency associated with alkaline soils. 6 work packages are planned: (i) local germplasm evaluation and implementation of regional citrus rootsto ck germplasm network, (ii) identification of physiological indicator of tolerance and development of standardized protocols for physiological evaluation ; analysis of relation between the variability of these indicator and variability of candidate genes (iii) search of candidate genes and study of their physical distribution on the genome, (iv) comparative genetic mapping between Citrus an Poncirus and analysis of recombination at intergeneric level, (v) development and optimisation of new breeding me thods including A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Logic of Informal Security Cooperation: Counterterrorism Intelligence-sharing in Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This MSCA research project on the logic of informal security cooperation (LINSEC) combines the research fields of security studies, IR, international history, and intelligence studies to answer the project’s overarching research question: What drives and sustains informal counterterrorism cooperation? To answer this question, LINSEC builds on the University of Southern Denmark’s  (SDU) expertise in security studies, my research experience in history and intelligence studies, interviews with intelligence officers, and my recently obtained unprecedented access to over 30,000 intelligence records from 1971 to 1979. These records are from a counterterrorism intelligence-sharing framework called the Club de Berne, which is still today’s main cooperation platform for informal intelligence-sharing on terrorism. To understand the logic of informal security cooperation, the project analyses four different aspects. (1) The prerequisites: what internal and external factors determine whether policymakers seek informal security cooperation. (2) Cooperation mechanism: how agencies react to terrorist threats and adapt their habits and modes of security cooperation. (3) Formal versus informal: the conditions under which these actors prefer informal over formal security cooperation, and how informal counterterrorism cooperation ties in or comes into conflict with formal alliances. (4) Continuity over time: what made informal counterterrorism cooperation effective in the 1970s and what makes it effective today? Each of these elements form one objective, which then contain a corresponding research, training, and dissemination subobjective. This project aligns squarely with the Horizon 2020 security research area and its aim of fostering secure European societies. Providing a better unders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'HOme WAves. Home-making and life trajectories in flood-risk areas of Central Mozambique'.

assistant: **Concept**

HOWA is an interdisciplinary research project belonging to critical African Studies, examining how home-making is reshaped under flood risk exposure in Central Mozambique. The project is premised on the conception of homes as speaking subjects telling us about the entanglements between individual paths, kinship, the environment and the socio-political context. In Mozambique’s low-income contexts, as elsewhere in Africa, people speak through their homes. House-building is a self-authored material and symbolic (non-verbal) language and, therefore, a fertile analytical field. In conditions of material, social and symbolic disruption, as is the case with repeated experiences of flooding, home-making and house building together reveal the complex life paths enacted within (and without) them. Floods are a major and increasingly frequent cause of disaster in eastern Sub-Saharan Africa. 30% of Mozambicans live in permanent flood vulnerability. HOWA investigates how home-making is reshaped in terms of (i) materiality, (ii) sociality and (iii) temporality under enduring flood exposure and displacement. It examines which life trajectories are enacted by, entangled with, and redirect through, the act of home-making before and after flood exposure. A relational and interdisciplinary approach is applied to the multiple dimensions of displacement and resettling. Different types of settings (urban neighbourhoods, resettlement sites, transitional areas) are studied with clusters of methods guided by an ethnographic and house biographical approach. The method itself becomes a form of activism enacted through the research process. By innovatively combining analysis of home-making, displacement, and life trajectories, HOWA in-depth, micro-scale studies hold both social and policy relevance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MEAT AUTOMATED CONCERTED ACTION' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The benefits of process automation are acknowledged in industries with consistent components. Many experts believe similar advantages can be gained in the meat and fish processing sector.The main of Meat Automation concerted action (MACA) is to capitalise on combined European expertise by bringing together key parties in development of automation for meat production. The strong partnership includes : meat producers to provide a background of production requirements, equipment manufacturers having a detailed knowledge of appropriate engineering solutions and established technology, and research organisations supplying expertise in meat research, new automation technologies and the R&D skills to bridge the knowledge gap. The concerted action will provide the forum for direct interaction between these groups, allowing dissemination of relevant information, generation of new business relationships, and rapid identification of opportunities. MACA will be administered by the Advanced Manufacturing and Automation Research Centre (AMARC) based at the University of Bristol, UK. AMARC has considerable expertise in developing automation for the meat sector and in co-ordinating EU funded programmes.The concerted action will achieve the aims of increasing the rate of development and implementation of automated systems in the European meat sector through a series of focused technical meetings and publications. At the first full project meeting each participants will be encouraged to give a short non-confidential presentation on the specific interests of their organisation. This data will be used to focus attention towards key technical areas for meat automation equipment. Technical area groups will be formed concentrating on the key aspects will be identified by the meat producer par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The potential of human kidney stem/progenitor cells for use in drug discovery and regenerative therapy programmes' (NEPHROTOOLS).

assistant: **Innovation**

Renal disease is a global public health problem, with the incidence of end stage renal disease (ESRD) rising annually. Current treatment options for ESRD are dialysis or renal transplantation, which have significant drawbacks in terms of increased morbidity and mortality, besides placing an increasing economic burden on society. The development of interventions aimed at preventing ESRD, including drug- and cellular-based therapies, is made difficult by the lack of availability of primary human renal cells for in vitro drug testing and by our inability to accurately assess the effectiveness of cellular-based therapies in appropriate animal models. However, due to recent advances in the fields of stem cell science, biomaterials and bioelectronics, we have unprecedented opportunities to generate the following tools that will facilitate important breakthroughs in renal medicine: (i) human kidney-derived stem/progenitor cells (KSPCs) for drug discovery and cellular therapy; (ii) biomaterials for regulating the differentiation of the KSPCs in vitro for use in drug development programmes; (iii) electronic devices capable of measuring renal function, enabling the effectiveness of stem cell-based therapies to be properly evaluated. The overarching goal of the NephroTools ITN is to provide state-of-the-art multidisciplinary training for a cohort of 15 young researchers in order to equip them with the skills required to make a significant impact in renal medicine and the wider field of stem cell biotechnology. To achieve this goal, the training of each researcher will be based around a specific research project, coupled with placement periods, within a multidisciplinary and cross-sectoral Network that aims to evaluate the potential of human kidney stem/progenitor cells for use in