RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of eco-friendly architectural coil coatings for clean buildings and pollution-free air', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

CleanCoat is a radically new eco-friendly coating designed specifically for metallic exteriors on high-rise buildings. Our success formula is based on a 70%PVDF matrix with embedded TiO2 nanoparticles (innovation) that simultaneously protects the metal against corrosion, keeps the surface clean (photocatalysis) and purifies the air by reducing pollutants (NO¬x and SOx), thereby addressing EU challenges on raw materials, pollution and ozone depletion. Users of our product are specialized coil coaters (end users) and real estate (final users) who have a need for high production efficiency, cost reductions and aesthetic quality. Thanks to CleanCoats’ embedded structure and NIR curing process, production time is reduced by 50%, cost by 30% and production capacity doubled. With a 30 year guaranteed durability, real estate companies will save up to € 100.000 per year on maintenance and cleaning and enjoy a high qualityaesthetic look by the self-cleaning surface, unlimited choice of colours and finishes, and outstanding colour retention and UV stability of the product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Expressive Agents for Symbiotic Education and Learning'.

assistant: **Objectives**

EASEL will explore and develop a theoretical understanding of human-robot symbiotic interaction (HRSI) where symbiosis is defined as the capacity of the robot and the person to mutually influence each other, and alter each other's behaviour over different time-scales (for instance, within encounters and across encounters). Symbiosis requires that the robot can read, and be responsive to, the behaviour and emotional state of the person, and adapt its own behaviour to take into account the user social context and extract knowledge from long sequences of behavioural interaction and changing its action responses accordingly.EASEL takes tutoring as validation domain. Current ICT applications for teaching and tutoring lack in their abilities for adaptation and only deal with limited problem spaces. EASEL will develop a new set of Robotic Based Tutoring Solutions (RBTS) and will deliver an innovative Synthetic Tutor Assistant (STA) incorporating key features of human tutors and other proven approaches capable to instruct a human user and learn from their interactions during large time scales. EASEL will develop new cross-disciplinary theoretical models for intelligent learning systems and test them into learning contexts including interaction with children, in the classroom and in museums.Scientifically we will develop new theories to address formally how a social context can be acquired and how new action possibilities could be learned. We base this social context formalization on the concept of social affordances, the new action possibilities arising from a bidirectional history of interactions that determine social and contextual priors. For this purpose EASEL will develop new spatial and temporal perceptual capabilities, to be able to process speech tokens, gestures, facia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Consumer-driven demands to reframe farming systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Intensive livestock production systems (ILPS) are growing fast to satisfy demand.  However, there is public scepticism about intensification in livestock production driven primarily by adverse links to environmental aspects and sustainable utilization of natural resources. Moreover, ILPS are perceived as being detrimental to animal health & welfare and may potentially undermine the quality of derived products. Extensive livestock production systems are low-input systems which are critical to support the development of rural communities. However, economic sustainability of such systems is often questioned as they are challenged by natural resource limitations, adverse climatic conditions and diseases. Products from extensive systems are considered of superior quality, but their resource-limited environment undermines their safety. Understanding key strengths & weaknesses of different farming systems is crucial for sustainable production and delivery of quality products. Therefore, strategic planning and a profitability analysis considering the system-oriented challenges and the added-value resulting from consumer-driven demands and niche products are necessary. Dairy cattle and swine production are the most significant livestock sectors in Europe. However, our proposal will take a different approach. When compared to cattle & swine production, both poultry and goat production systems are more resilient, sustainable and adaptable to change. Code:Re-Farm focuses on poultry & goat production systems with the goal of understanding the links between husbandry systems and intrinsic quality of derived products. Novel technologies will also be exploited for assessing the intrinsic quality of products along the value chain, farm to fork. The insights from this assessment, combine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Impacts of Ocean Acidification on Bacterioplankton Functioning: Effects on Proteorhodopsin-containing Marine Bacteria'.

assistant: **Objectives**

The increasing CO2 levels in the atmosphere and its high uptake by the oceans are lowering the pH of the oceans. Dramatic changes in ocean pH have been shown to negatively affect ocean biota such as phytoplankton and coral reefs. However, there is little known regarding the impact of decreasing ocean pH on marine bacteria. This project seeks to evaluate the effects of the ocean acidification on the structure and function of marine bacterioplankton communities. Proteorhodopsin (PR) phototrophy are widespread among marine bacterioplankton species and its functioning has been predicted to be seriously affected by future pH reductions. This proposal will examine the performance of PR-containing bacteria in this global change scenario. Bacterial responses to pH will be analyzed in: 1) highly controlled systems (physiology of bacteria in pure cultures) 2) relatively controlled systems (physiology and diversity of bacteria in mesocosm experiments), and 3) field studies (in situ physiology and diversity analyses of native bacterioplankton communities). These three degrees of control/manipulation will give this project a unique perspective that will improve our capacity to predict the consequences of the projected pH alteration. The proposed research will follow the European Science Foundation recommendations by addressing the consequences of the important climate change problem of ocean acidification from the organismal and ecosystem perspective in a national and international level. Moreover, this project will contribute to the objectives of the Work Programme by: 1) allowing me to gain new skills in oceanographic fieldwork and experimental manipulations; and to become an EU leading specialist in a rapidly growing research field 2) transferring the acquired knowledge to the EU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'NANOstructured active MAGneto-plasmonic MAterials'.

assistant: **Concept**

The development of a novel concept of nanostructured material is involved in this project: the proper combination of magneto-optical (MO) and plasmonic elements to produce a magneto-plasmonic material tailored on the nanoscale.  The novel magneto-plasmonic materials will offer the unique ability to control their properties in more than one way, since the magneto-optical activity will be affected by the alteration of the plasmonic characteristics and the optical response will depend on the magnetic ones. The latter puts an additional advantage over conventional materials, since the optical response can be actively tuned by means of an external agent: a magnetic field. The project has two main goals; the first is to prepare active magneto-plasmonic materials with tailored properties in the nanoscale and understanding the interactions of the magnetic properties with the plasmonic and optical ones, linked to electric charge oscillations. The second goal is to develop prototypes of applications that can benefit of this coupling. Since it is expected that the optical properties of these materials can be driven by using a magnetic field, this will allow designing and developing novel magneto-plasmonic devices. In particular, as a proof of the applicability of this concept, we will design, fabricate and test a prototype of a new kind of surface plasmon resonance (SPR) biosensor with MO elements, i.e. a surface magneto-plasmon resonance (SMPR) biosensor, comparing its performance against standard biosensors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multi-Gigabit European Research and Education Network and Associated Services (GN3)', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of this proposal is the creation of a leading edge network supporting a much enhanced range of both network and added value services targeted at end-users across the GÉANT service area. A principal goal will be to create a portfolio of seamless multi-domain services. In contrast to its predecessor, GN2, much more emphasis is placed on service development and service introduction.Initiatives are planned in the areas of multi-domain network service operation, where it is planned to organise quick and efficient provisioning of advanced services, develop operational support crossing management domains and security to ensure service integrity and protection of network resources. This will be complemented by the development of end-user services in a federated environment which will focus on the creation of generic meta-services", particularly in the context of security as well as further developments in the area of Roaming Services.Individual Tasks within the Joint Research Activities (JRAs) will be of shorter duration and more targeted than in GN2. The initial JRAs will deal with a critical analysis of future networking technologies as well as research into new services both from the point of supporting the development of new services as well as researching into enhancements to the emerging service portfolio (monitoring, mobility and resources management).These will be supported by Networking Activities (NAs) dealing with both internal and external project communications. A particular emphasis of the NAs will be to support and encourage the take up of services among end-users by working closely with NRENs. The need to develop this theme co-operatively with other world regions is recognised by the inclusion of an activity specifically targeted to achieve this.A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Anti-Cancer Light-Controllable Antibody-Peptide Conjugates' to be submitted under Horizon 2020.

assistant: **Abstract**

Project ALISE (Antibody Light-Induced Selectivity Enhancement) will integrate the expertise, resources and knowledge of participating Institutions focusing on design, synthesis and preclinical study of conjugates of monoclonal antibodies with peptides whose anti-cancer activity can be enhanced in tumours by irradiation with light (LC-APCs). The possibility to boost the anti-cancer activity only in tumours, multiplied by targeting cancer cells by antibodies will be a basis for innovative and safer therapeutic strategies. Four of seven participating Institutions successfully collaborated in the field of light-controllable anticancer peptides, but this Project will widen the scope of collaboration, both in terms of the research field and collaborating Institutions. The participating Institutions are complementary in their expertise and know-how: the University of Cambridge will contribute with its know-how in design and preparation of antibodies. Light controllable peptides will be designed at Latvian Institute of Organic Synthesis and Karlsruhe Institute of Technology, synthesized, then loaded onto the antibodies in Cambridge. Company Enamine will perform initial screening of the conjugates in vitro and assess their safety. National Cancer Institute of Ukraine will contribute with its expertise in immunology, Cancer Center Amsterdam – with its expertise and knowledge in preclinical and clinical oncology. Lumobiotics GmbH will complement the consortium with its expertise in drug development. Integration of this potential will be achieved through research staff exchange and other activities organized in five work packages: 1) design and synthesis of novel light-controllable peptides as anti-cancer antibody payloads; 2) preparation and characterization of peptide conjugates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Neural mechanism underlying the central regulation of male sexual arousal and ejaculation' to be submitted under Horizon 2020.

assistant: **Abstract**

Sexual behavior patterns are unique among the behavioral repertoire of animals. Sex serves no survival advantage for the individual per se, but is vital for species preservation.  To this end, evolution has hedonically biased animals to engage in behaviors that culminate in the conspecific transfer of genetic material. Male sexual behavior is characterized by distinct phases in this behavioral action sequence leading up to ejaculation. Lesions of the medial preoptic area (MPOA), an anterior extension of the hypothalamus, in rodents have been shown to eliminate both reward-seeking, or appetitive (female pursuit and anogenital investigation), and reward-consuming, or consummatory (mounting, intromissions, and ejaculation), male sexual behaviors. Furthermore, focal lesion studies and physiological evidence suggests the presence of separate populations within the MPOA mediating the control of these two phases, and behavioral evidence points to the idea that the performance of appetitive and consummatory behaviors are reciprocally related. However, the mechanistic role of the MPOA in controlling downstream circuitry facilitating male sexual arousal, copulation, and the interaction of these dimensions of behavior has not been explored.  This proposal aims to understand how male sexual arousal and copulatory performance are encoded in the brain, utilizing activity-dependent genetic labeling approaches, in vivo calcium imaging, causal optogenetic manipulation of neuronal subpopulations, and genetic-based tracing methods.  The project will be the first to mechanistically address how the brain provides descending control over male arousal and ejaculation, exposing potential central mechanisms that could be acted on for the treatment of sexual dysfunction.


**Keywords:** neuroeth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Targetted therapies for inflammatory bowel disease' under Sixth Framework.

assistant: **Concept**

Inflammatory bowel diseases such as Crohn's disease still lack efficient, cost effective treatments. Using recent advances in drug design, the partners have identified a new therapeutic drug class that has the potential to cut annual treatment costs while offering a better level of treatment than is currently available. The goals of this proposal are, therefore to: Select and improve the new anti-inflammatory compounds using partner technologies Formulate them for use in the context of bowel disease Test them in advanced disease models Select a clinical candidate and demonstrate safety in standard toxicological models It is now clear that tumour necrosis factor (TNF) plays an important role in Crohn's disease pathology and reductions in the production of this cytokine result in disease remission.TNF is produced in response to stimulation amplified via key signalling proteins including kinase enzymes and blockade of this enzyme is effective in preventing TNF production. The most abundant source of TNF is the activated macrophage, an immune cell that is accumulated in sites of chronic disease where a drug must act in order to reverse progress of disease. Optimal drug safety and efficacy will depend on maximising the amount of drug available to macrophage while limiting the overall dose and exposure to the rest of the body. The project, therefore, sets out to improve p38 kinase inhibitors using a combination of computer aided drug design, and a novel technology for assisting drug partition to macrophage. The partners will use high-resolution models of p38 kinase and selectively designed drug conjugates to identify potent new inhibitors of macrophage TNF production. These will be tested for activity in models of inflammatory bowel disease and progressed into pre-clinical de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Mouse Major Urinary Proteins complex: an ideal model to investigate animal pheromonal communication and human allergy.' under Sixth Framework.

assistant: **Concept**

Aims: a) to study how the diverse biological functions of the recombinant lipocalin Major Urinary Protein (rMUP) including the ability to bind pheromones and odours and its pheromonal and allergen activity correlate with and are modulated by its structural and molecular dynamic features. b) to complete the training in Structural Biology focusing biomedical/biotechnological applications. a1) The request of new and more specific artificial sensors in food industry or environment control is increasing. MUPs bi ological activity is associated to the binding of hydrophobic molecules inside their pocket. A goal is to pin down the residues involved in binding and selectivity. Based on this knowledge we will design new mutants characterized by specific affinity for s elected compounds. a2) More than 20% of the population in industrialized countries suffer of allergies. MUPs are potent human allergens. Peptides encompassing portions of rMUP will be studied in search of the epitope(s) responsible for this pathological ef fect. This will allow to develop safer and more tolerable preparation for immunotheraphy. a3) The folding process of proteins is yet not understood. The beta-barrel lipocalins pose challenging questions since they may acquire non-native intermediate confor mational states. Unveiling the structure and dynamics of these states will be important to further the knowledge on the molecular mechanisms associated to protein folding and will allow to better understand how MUPs and lipocalins at large can carry out th ose so diversified biological functions. b1) To tackle biomedical or biotechnological problems it requires the combined use of structural biology tools: protein engineering and immunological techniques, multinuclear multidimensional NMR, fluorescence and c ir