RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mind the Gut: Molecular Markers of Microbiome Evolution' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

What is the role of our microbial partners in our evolution? Does the microbiome evolution reflect major events of human history? Despite increasing evidence that the gut microbiome plays an essential role in multiple core aspects of human biology, little is known about how the human-gut community co-evolved. The role of the microbiome in human evolution and speciation has been historically overlooked, in part due to the challenge of obtaining microbiome data from ancient material. However, understanding the co-evolution of the human-gut ecosystem requires a time-series approach associated with the major defining moments in human evolution such as migrations, admixture, domestication, industrialization and globalisation. Under favourable conditions some archaeological substrates such mummified tissues, coprolites and dental calculus have potential to shed some light on ancient microbiomes. To do so, MIND THE GUT (MtG) will develop new markers of specific bacterial action applying lipidomic and proteomic tools to explore the diagenesis of microbiome substrates. MtG will analyze the mummified microbiomes of the aboriginal Canary islanders. The Canary mummies represent a unique model system to study the impact of diet and lifestyle in populations that evolved isolated but shared their microbiome during the peuplement of the islands. MtG will compare them with a group of naturally mummified bodies from Nubia that span a similar time period, and with modern microbiome samples from 3 african populations with different lifestyles.  MtG results will provide a framework for future studies on fossil material and contribute to illuminate the role of the microbiome in overcoming the challenges of diet, environment and lifestyle changes that took place during human history and prehi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'High Precision Composites Moulding prediction of Distortion Using Analytical Methods'.

assistant: **Concept**

Advanced composite materials are one of the main keys to lightweight, energy efficient structures for Next Generation Aircraft. Unfortunately, there is a serious technical and economic barrier to their cost effective application in areas where accuracy is critical, due to the uncontrolled and largely unpredictable distortion which occurs during the moulding stage. There are many factors affecting this phenomenon, but the net result is often several remakes of tooling to attempt to correct for distortion or spring back, a high scrap rate (often over 40%) and costly assembly problems, since composites are elastic and cannot be bent to shape. The purpose of this research project is to develop an analytical method and associated database for predicting distortion phenomena and to create a materials and processing model to ensure that the production moulding process can be specified and controlled to achieve consistent high precision and reduce scrap rates to less than 5%. The overall aim is to reduce time to market for prototypes and production mouldings, with right first time, predictable component accuracy saving typically three to six months lead time. Also to achieve repeatable, high accuracy in series production mouldings to avoid scrap, reduce rework and achieve closer fit of assemblies. The target is to reduce factory floor costs of producing composite parts by at least 30%. (P1 has conducted tests on assembly cost savings which concur with this figure). This will, in turn, make the composites option commercially more viable to other transport sectors and to general industry. Specific objectives are: a) Obtain a scientific understanding of materials and processing factors affecting composite part accuracy b) Quantify the significant parameters, their interactions and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Commercialising cardiac autonomic modulation to treat Atrial Fibrillation' (Neuron-AFib).

assistant: **Concept**

Atrial Fibrillation (AFib) is a debilitating and life-threatening condition with a high and increasing prevalence worldwide. However current treatments have low success rates and have significant risks and complications. Moreover, the most widely used treatment – cardiac ablation - still has limited adoption with the majority of patients hesitant to be treated knowing the potential for poor outcomes and complications. In addition, current treatments have even lower success rates and higher complications in women.AtriAN Medical is bringing a revolutionary treatment to market that is the first to specifically target the origin of the signal that causes AFib, thus eliminating the arrhythmia and disease progression. In addition to increased success rates, the AtriAN technology will reduce the risk of complications and the procedure will be done in a fraction of the time needed for current treatments; approximately 2 hours compared to 6-8 hours. The treatment will work equally well in women and men.AtriAN conservatively estimates that it will have turnovers of €85M per annum within one year of regulatory approvals. AtriAN has a senior management team in place with significant medical device industry experience in technology development, manufacturing and scale up from start-up to multinational size.AtriAN needs to perform a clinical trial in order to gain CE-marking to allow sales in Europe. AtriAN is planning for CE approvals by 2022 and FDA approval by 2026. The proposed Neuron AFib project will first finalise the device testing and validation needed in order to meet regulatory requirements and will then perform the clinical trial, with equal female and male enrolment, in order to demonstrate safety and efficacy of the treatment. AtriAN has already raised €3.8 million of f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PROTOCALC: a prototype for a polarized calibrator for CMB experiments' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

My project will enable unprecedented measurements for cosmology and fundamental physics, thanks to a prototype calibrator for a novel method to measure the angle of the polarization plane of the Cosmic Microwave Background. Polarization orientation systematics currently limit our ability to constrain cosmological parameters. PROTOCALC will provide a prototype calibration source to overcome this limit, dramatically improving instrumental accuracy. This experimental method will also enable us to discover (or place extremely tight limits on) paradigm shifting phenomena through Cosmic Birefringence, a departure from Standard Model. During the 2-year program I will develop, build and deploy a prototype for a novel precision calibrator making use of microwave sources between 40 and 150 GHz coupled to precise polarizing filters. The orientation of the source polarization plane will be measured by star cameras and gyroscopes with arcsecond accuracy. POLOCALC will take advantage of my and the supervisor's ongoing participation in the Simons Observatory which already includes the AdvACTPol and Simons Array projects, and will operate from the same site in the Atacama desert in Chile. Our project will operate from from a drone flying in sight of the telescope, allowing high elevation, far field measurements. This project will show the feasibility for polarization angle and beam calibrators for future CMB polarimeters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Coordination chemistry in doubly stabilized micelles for the tageted delivery of cytostatic drugs in cancer therapy' (2014-2020).

assistant: **Innovation**

The treatment of cancer with chemotherapeutic drugs is very often associated with severe side effects limiting their tolerated dose and leading to insufficient therapeutic effects. The application of such drugs in nanometer-sized micelles may improve their biodistribution, but in vivo studies showed fast drug release in the blood stream. We aim for prolonged drug retention and intracellular release by introducing the stable, yet reversible Lx linker in the core of bioresorbable polymeric micelles. This coordinative platinum linker will have two functions: (1) it will facilitate the stable conjugation between the drug molecule and the polymer molecules constituting the micelle and (2) it will act as a stabilizer between the polymer molecules constituting the micelle. This will result in excellent stability of the drug-loaded micelles in circulation. Due to the enhanced permeability and retention effect the micelles will accumulate in tumor tissue, where they will be destabilized intracellularly and the drugs will be released from the linker in the cytoplasm after competitive glutathione displacement. The Lx linker presents various advantages over other crosslink methods, such as versatility and ease of crosslinking. No platinum-related toxicity was observed in vivo for the linker in previous research. In addition, the amount of platinum may be considered negligible since powerful drugs will be loaded onto the micelles.This approach represents a safe and unique hybrid method which has the potential to significantly increase the amount of drug deposited at the target tissue and to reduce side effects at non-target sites. By pursuing this significant step forward in cancer therapy, the fellowship will broaden the Experienced Researcher’s scientific and non-scientific skills
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integration at pilot scale of high cell density bioreactor operation with ultra fast on-line downstream processing' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

This project aims at validating - at pilot scale - a continuous process whereby heterologous glycoproteins secreted from mammalian cells propagated in continuously stirred tank reactor are extensively purified by an uninterrupted downstream processing.  The original aspects of the Demonstration are:  - integration of high cell density cultivation with ultra fast on-line downstream processing - validation of sonoperfusion at 8L- and 20L culture volume scale - validation of the high cell concentration per unit culture volume" concept - use of state-of-the art support for Expanded Bed specific Adsorption (EBSA) - use of specific solid phase screening methods for the selection of chromatographic ligands."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel Calculation and Analysis Method, Planning and Application Platform That Personalizes the Mathematical Definition of Spinal Alignment and Shape (GAP Simulator)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

THE MOTIVATION & CHALLENGESMore than 1 out of 3 patients (>33%) have mechanical complications after spine surgery despite various efforts of calculation and planning.  Approximately 50% of patients who experience a mechanical complication require a second intervention for a revision surgery, which negatively affects the patient’s well-being and causes increased cost and issues regarding insurance payments. Despite revision surgeries, ideal sagittal alignment still cannot be obtained in some patients. Therefore, to eliminate these negative outcomes due to the currently used population-based analysis methods there is a need for personalised analysis and surgical planning.THE IDEA: GAP SIMULATORGAP Simulator is a novel sagittal spinal shape and alignment analysis method and application platform. GAP Simulator is used for preventive medicine applications and for the diagnosis and treatment of spinal disorders utilised in the fields of Orthopaedics and Traumatology, Neurosurgery, Physiotherapy, and in related fields. The GAP analysis and planning system, uses relative angular values to denote deviations from the calculated ideal, and is the first revolutionary system developed for prevention of mechanical complications by personalised preoperative planning. GAP analysis quantifies the spatial orientation of the pelvis, magnitude and distribution of the lumbar lordosis and global spinopelvic alignment via pelvic incidence-adjusted radiographic parameters.OUR MARKET: Spine Surgical Planning and Spinal Implants Market.The global spinal surgery devices market was valued at €10.46billion in 2018, and is estimated to be valued at €14.35 million in 2024, witnessing a CAGR of 5.30%. GAP Simulator is expected to grab up to 0.957% of this market 5 years post commercialisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced Cellular Hierarchical Tissue-Imitations based on Excluded Volume Effect' (ACHIEVE), addressing dissemination and exploitation.

assistant: **Impact**

ACHIEVE focuses on the application of Excluded Volume Effect in cell culture systems in order to enhance Extracellular Matrix (ECM) deposition.  It represents a new horizon in in vitro cell culture which will address major challenges in medical advancement and food security. ACHIEVE will elucidate extracellular processes which occur during tissue generation, identifying favourable conditions for optimum tissue cultivation in vitro. These results will be applied in the diverse fields of regenerative medicine, drug discovery and cellular agriculture which all require advancements in in vitro tissue engineering to overcome current bottlenecks.  Effective in vitro tissue culture is currently limited by lengthy culture periods.  An inability to maintain physiologic (in vivo) conditions during this lengthy in vitro culture leads to cellular phenotype drift, ultimately resulting in generation of an undesired tissue.   Enhanced tissue generation in vitro will greatly reduce culture times and costs, effecting improved in vitro tissue substitutes which remain true to their original phenotype.  The research will be addressed under four work-packages.  WP1 will investigate biochemical, biophysical and biological responses to varying culture conditions; WP 2, 3 and 4  will apply results in the fields of Tissue Engineering, Drug Discovery and Cellular Agriculture respectively.  Research will involve extensive characterisation of derived- and stem-cell cultures in varying conditions of expansion and relevant health and safety and preclinical testing. The five year programme will be undertaken at the National University of Ireland, Galway, a centre of excellence in tissue engineering research, at a cost of  2,439,270.


**Keywords:** Cell culture, in vitro, extracellular matrix, macrom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mathematical Virology: A classification of virus architecture and the structural transitions important for maturation and infection' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project in Mathematical Biology addresses two important questions concerning the structure and life cycle of viruses: -) The classification of the possible three-dimensional shapes of the capsid proteins compatible with icosahedral symmetry (the most common symmetry of viral capsids) by means of group theory and tiling theory; -) The modeling and prediction of the structural transitions of the viral capsids (protein containers encapsidating the genome) involved in the maturation of the viral particles, using ideas and techniques of the mathematical theory of phase transitions in crystals. The expected results will clarify, on a geometrical basis, the spectrum of structural features that can occur in the viral capsids with icosahedral symmetry (such as the shape and the bonds between the proteins) and elucidate the mechanisms essential for their maturation and infectivity. Such insights have relevant implications for the design of antiviral drugs that inhibit the assembly or the maturation of viral capsids, and the manufacture of self-assembling virus-like containers for drug delivery.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Solar Atmospheric and Interplanetary Research' (SOLAIRE).

assistant: **Concept**

The Solar network joins twelve leading European research groups specialized in computational, theoretical and observational solar physics and an industrial partner (an SME) that develops state-of-the-art 3D computer codes and high level 3D visualization tools. We aim to provide a multi-disciplinary, flexible framework to train a new generation of solar physicists. We will tackle some of the fundamental unsolved problems in solar physics, preparing the young scientists to exploit the unprecedented computational and observational capabilities (ground-based telescopes and satellite missions) available to the solar scientists at present and in the near future. Key areas included in our proposal are: emergence of magnetic flux through the solar surface into the solar atmosphere and interplanetary space; connectivity and interaction of the atmospheric layers and reconstruction of the coronal field; magnetic reconnection; solar flares; solar eruptions that violently affect the interplanetary medium. Our approach is multi-disciplinary and firmly based on the careful combination of computer experiments, observations from the ground and space, and analytical models. The network partners have been directly involved in the development of advanced computational tools (3D computer codes, visualization packages), observational facilities and in the planning of space missions. Therefore, they are optimally situated to pass their expertise on to a new generation of astronomers. We propose an ambitious network-based training, with joint supervision of ESRs through two network experts in different disciplines. Of particular interest is the interaction we foresee between the industrial and academic partners of the project. The network activities include 5 post-graduate schools, network mee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of a cell-based system for high-throughput screening of antifibrotics'.

assistant: **Objectives**

Liver fibrosis (hepatitis B and C, cirrhosis, etc) represents an enormous health burden responsible for ~1.03 millions death per year worldwide according to the World Health Organization. Fibrosis is also a common outcome of many chronic diseases of the kidney (diabetic nephropathy), lungs (idiopathic pulmonary fibrosis), heart and vasculature (heart failure). In pathologies where fibrosis is a feature, there is an increased deposition of extracellular matrix proteins, including collagens that dramatically limit tissue function. Herein we propose to develop a cell-based assay for high-throughput screening of new antifibrotic therapeutics, which will accelerate fibrosis drug development. Our approach consists in the metabolic incorporation of an alkene-tagged proline in the biosynthesis of collagen, followed by labelling with a fluorescent tetrazine. We recently published preliminary results that provide proof of principle for the use of proline derivatives equipped with reactive handles to tag and label collagen structures. However, this approach suffered from nonspecific reactions of the fluorescent probe with intracellular proteins. The level of selectivity conferred by the proposed inverse-electron-demand Diels-Alder reaction is key in enabling its use in cells. We will use hepatic stellate cells since these cells are responsible for excess collagen production during liver fibrosis. To demonstrate that the cellular model can be used to screen compounds for fibrosis we will validate our system using a library of compounds with known preclinical antifibrotic activities. We will test if their in vivo efficacy can be predicted using cells. If our findings are significant we will use this cellular model to screen a commercial available library of compounds to find new ant