RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SUPPRESSION OF RNA DEGRADATION BY PLANT PARARETROVIRUS: HIJACKING OF DECAPPING COMPLEXES' under Seventh Framework.

assistant: **Concept**

During pathogenesis, viruses hijack the cellular machinery to access molecules and sub-cellular structures needed for infection. Viruses counteract plant defences by producing suppressor proteins. We have evidence that multifunctional viral protein—translation transactivator/ viroplasmin from Cauliflower mosaic virus, CaMV—could be used as a suppressor of cellular RNA turnover: the cellular accumulation of TAV inhibits cellular mRNA decay and suggests its complex formation with the decapping machinery within P-bodies.We shall investigate whether TAV of CaMV and related pararetroviruses serves as a suppressor of cellular and viral RNA degradation, and whether TAV is operated within either the deadenylation complex, which primes mRNA degradation, and/or the decapping complex, where TAV integrates. We shall test whether transient or stable over-expression of the CaMV TAV as a wild type or a mutant form is able to suppress degradation of cellular or viral RNAs. We shall determine the component of the degradation machinery that ensures TAV entry into the decapping complex/ P-bodies. Thus, we are interesting in studying the TAV interaction network within the decapping/ deadenylation complexes.These studies should reveal whether viral protein-based suppression of RNA degradation is a universal mechanism employed by plant pararetroviruses and, perhaps, also animal retroviruses. Additionally we shall identify RNA-based targets within cellular and viral mRNAs, and study whether synergistic suppression of RNA degradation by viral suppressor might contribute to  CaMV virulence. This will help to design new strategies to counteract mRNA degradation in general using plant pararetroviral vector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hydrogen Railway Applications International Lighthouse' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

HyRAIL aims to make an assessment of the state of the art of technologies available and R&D activities and projects on hydrogen and fuel cell, drawing possible scenarios of transport system and energy supply related to railways. Gaps and technological innovations will be identified and proposal put forward to solve fragmentation and to remove bottlenecks. HyRAIL may provide a vision" and draw a position paper for its implementation in European Railways for the medium long term. Particular attention will be paid to identify user's needs and industrial suppliers, especially for SME, as well as cost and benefits, energetic and environmental issues will be taken into account. Areas of business and sustainable use of energy and resources will be investigated. The results of discussions will strengthen and update the vision, the deployment strategy (DS) and the strategic research agenda (SRA) of EU Hydrogen and Fuel Cells Platform (HFP), as basis for further projects to be set up as response to next call series of FP7. Partners will organise an initial workshop to gather the state of the art and evidence of interest by stakeholders and take & transfer opportunities from other sectors. A workgroup inside SSA participants, open to external contributions, will develop the position paper, according to the results of the workshop. A final conference and a website, in order to present the results of the project and the guidelines for the setting up of adequate initiatives, will be organised. The final goal is to strengthen European Rail actor's collaboration, rendering it more effective as well as corresponding to their major interests, showing in conclusion possible applicability areas of hydrogen in railway sector."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synthesis of sp3-Rich Organofluorine Compounds through Homologation of Boronic Esters' to be submitted under Horizon 2020.

assistant: **Abstract**

Organofluorine compounds are highly sought after owing to diverse and numerous applications that take advantage of the unique properties imparted by the presence of one or more C–F bonds. The chemical stability and conformational landscape of molecules, together with the small size of the fluorine atom, has the made the replacement of a C–H or C–OH bond with a C–F one of the most rewarding modifications during the hit-to-lead stage in medicinal chemistry programs. Because many applications are dependent on the absolute and relative configuration of the fluorine-containing group, methods that can introduce such groups in a stereoselective manner are particularly attractive. The host laboratory has shown that substituted carbon chains can be grown one carbon atom at a time with exquisite control of relative and absolute configuration through iterative homologation of boronic esters with stereochemically-defined lithiated carbamates or benzoates. The latter are formed at low temperature, either through sparteine-mediated enantioselective deprotonation of primary carbamates/benzoates or the enantiospecific deprotonation or tin–lithium exchange of enantiomerically pure secondary carbamates/ benzoates. Although the process works well for extending a carbon chain with incorporation of carbon-based substituents, the incorporation of carbon atoms bearing electronegative substituents, such as oxygen- or fluorine-containing groups, is challenging. Herein we propose a programme of research to investigate the preparation of enantiomerically enriched organofluorine molecules, specifically those containing trifluoromethyl groups, through lithiation–borylation. The challenges outline above would make such a programme the ideal sharpening stone for the further development of lithiation–
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Emission reduction from engines and transmissions substituting harmful additives in biolubricants by triboreactive materials.' (EREBIO) under Fifth Framework.

assistant: **Objectives**

Quality of life in the EU is under pressure from increasing pollution. The objective of this project is to substitute petrol oils (reduce CO2 emissions) by. new compatible low viscosity (reduce fuel consumption) biodegradable engine an gear oils based on native poliolesters or water based polialquilen glycols, eliminating toxic triboactive additives (reduce particulate emissions). The innovative approach is to consider a system problem not a lubricant problem: the role of toxic EP/AW additives (Cl, S-Zn,..) will be taken by the use of tribo-reactive materials. The interactions between the polar ecolubricants with understoichiometric coatings , self lubricant and triboximaterials (understoichiometric oxides, TiCrO, FeCrO, TiO) will be studied to apply to reduce friction, wear, noise and vibrations in land and marine transport.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Product focused concurrent engineering'.

assistant: **Concept**

PROFOCE PROJECT OVERVIEW This project deals with the creation of a thematic network, which covers the 'Concurrent Engineering' domain in general. On account of today's high level product integration, Design and Manufacturing should create and use new methods and tools to be more efficient and competitive. This new approach, especially developed by Aircraft and Automotive industries, is called 'Concurrent Engineering'. Concurrent Engineering can be considered as a suite of concepts, methods, organisation means and tools giving to a group of interested actors within a design process simultaneous access to the same pool of data and thus, enabling the latter to make decisions in concerted action and to optimise performance, lead-times, costs and quality throughout a product's life cycle. Introducing Concurrent Engineering practices in the industry is a revolution. Consequently the Industry, and society from a more general point of view should thus be prepared to accept and deal with these new working methods. The purpose of the proposed thematic network is to ensure that the global process of Concurrent Engineering is well defined and suited to the targeted objectives of the Industry. It will ensure that already started projects do work 'Concurrently' and not, in competition, and that new needs and requirements are in future properly taken in account in accordance with the general Concurrent Engineering Process. One further goal of this thematic network is to avoid, as far as possible, redundancy in the Concurrent Engineering work programme deployment throughout the whole European Industry. EUROPEAN DIMENSION AND PARTNERSHIP The current state of the art is found in the industrial use of the Concurrent Engineering approach and, in particular, in its integration business proc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Centre of excellence in plant agrobiology and molecular genetics', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

1.Theoretical and practical training of young scientists and Ph.D. students in modern molecular plant genetics - establishing the leading training centre for Eastern Europe.2.Creation of international network in agricultural sciences and tight bounds with twin EU laboratories.3.Entering into co-operation with end-users from state-owned and private companies. Establishing the platform of common discussion concerning the adjustment of Polish agriculture to the Common EU Agricultural Policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'New Frontiers in Propellane Chemistry'.

assistant: **Concept**

Propellanes are molecules of high importance as precursors to valuable cage molecules in pharmaceutical and materials research. For smaller-ring propellanes, ubiquitous reactivity can be displayed towards anions, radicals, and cations; however, the theoretical basis for this unusual behaviour has only recently emerged, which is based on the ability of small ring propellanes to delocalise electron density away from the electron-rich central C–C bond onto the peripheral carbon atom p orbitals both in the ground state, and during reactions. In this project we develop chemical tools to test this theoretical model, offering experimental support and characterising the change in structure and electronics during ring opening processes. We further develop new synthetic methodology to access high-value (but hard to access) chiral propellane ring-opening products, and explore new modes of propellane reactivity by employing novel catalytic concepts to activate the central C–C bond. We use a theoretical 'carbene' description of [1.1.1]propellane to open up access to bridge-substituted propellanes, which represent a 'holy grail' of the field, and also explore methods to control the dimerisation or oligomerisation of these molecules. Collectively, using the most up to date theoretical models (and in collaboration with theoretical chemists) we aim to develop a new frontier of propellane chemistry, which has the potential for broad impact on its many applications.


**Keywords:** Propellanes, Catalysis, Mechanistic Studies, Theoretical Calculations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart Network Operator Platform enabling Shared, Integrated and more Sustainable Urban Freight Logistics' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The main objective of SENATOR project is to provide 4 governance schemes for urban planning policies: User demand planning, Transport planning, Freight & Logistics planning and City infrastructure focused, bringing together relevant stakeholders in urban freight logistics within one multi-collaborative framework based on a new urban logistics model to attend the requirements of the 'on demand economy'. As a result, urban governability will be enhanced considering i) citizen empowerment; ii) integration of new sustainable transport modes; iii) efficient logistics through digitalisation and; iv) urban space management. This urban logistics model demands another role under new planning processes. SENATOR proposes a smart network operator, as integrator, based on a multi-level system model, which enables load pooling and offers a better decision-making and real time control process.SENATOR will deliver an innovative “control tower” approach, allowing dynamic planning and ensuring operative optimisation through a fluent relationship between urban planners, urban freight logistics players and citizen engagement. This will be actuated in a platform which balances demand of freight & delivery services with available vehicle load for on-demand city needs. The main concept behind the project idea is to create a new urban logistic model focused on the four urban layers (end-receiver, transport, logistics and infrastructure). This will provide integrated models for urban planning policies. This urban logistics model creates a new role, the smart network operator that boost collaboration among all freight urban logistic agents. Based on a multi-level system model for urban space management promoting sustainability and shared-connected freight and delivery services in cities, SENATOR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The role of eEF1A in synapse function, maintenance, and synucleinopathy'.

assistant: **Objectives**

Synucleinopathies are neurodegenerative conditions characterized by an accumulation of the protein alpha-synuclein, including Parkinson's disease and dementia with Lewy bodies. A long asymptomatic phase precedes the onset of invalidating symptoms. Early diagnostics and treatments are hampered by an incomplete understanding of the pathophysiological mechanisms. The Host has recently identified the synaptic depletion of protein elongation factor 1A (eEF1A) at early stage of the disease. In EaSYFUN, the Fellow proposes to combine state of the art genome editing with transgenic murine disease model and human induced pluripotent stem cell derived neurons to unravel eEF1A function at synapses, characterize in depth its alterations in synucleinopathy, and question its pathophysiological role in the disease onset and progress. In Aim1 we shall provide a spatiotemporal map of eEF1A in neurons and its depletion in pathology. In Aim2 we will explore knock-down and rescue of eEF1A variants. We will test whether eEF1A depletion is necessary and sufficient to lead to all or some aspects of synucleinopathy. In Aim3 we will explore the functions of eEF1A variants at synapse (protein translation or degradation, regulation of synaptic vesicle cycle, spine structure) and the binding partners of eEF1A through proteomics. We will provide insights into the alterations of synaptic functions in synucleinopathy and the role of eEF1A. The applicant will benefit from established protocols by the Host and will bring new expertise to tackle eEF1A function at synapses with unprecedented resolution and to provide new therapeutic avenues for Synucleinopathy. EaSYFUN will benefit from an ongoing collaboration with Pr Jochen Herms (DZNE, Munich, Germany). The proposed work will expand the Fellows core s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'HYCELAND : Iceland Small Hydrogen Valley'.

assistant: **Innovation**

HYCELAND is a Small Hydrogen Valley project in Iceland, which will produce hydrogen to serve end users across mobility, industry and power sector applications. The project is being led by Landsvirkjun (the national power company of Iceland) in partnership with Linde (one of the world's leading industrial gas suppliers), who have established a consortium of partners to cover the entire value chain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deep BIOmodeling of human CARDiogenesis' (BIOCARD).

assistant: **Concept**

The heart is one of the first and most complex organs formed during human embryogenesis. While its anatomy and physiology have been extensively studied over centuries, the normal development of human heart and dysregulation in disease still remain poorly understood at the molecular/cellular level. Stem cell technologies hold promise for modelling development, analysing disease mechanisms, and developing potential therapies. By combining multidisciplinary approaches centred on human induced pluripotent stem cells (hiPSCs), BIOCARD aims at decoding the cellular and molecular principles of human cardiogenesis and developing advanced inter-chimeric human-pig models of cardiac development and disease. State-of-the-art genetic modification techniques and functional genomics will be used to establish a molecular atlas of cell type intermediates of human cardiogenesis in vitro and unravel how their proliferation, differentiation and lineage choice are regulated in health and disease. This in vitro approach will be complemented by detailed analyses of how distinct hiPSC-derived cardiac progenitor populations commit and contribute to specific cardiac compartments in interspecies chimeric hearts in vivo. Finally, we will capitalize on the novel concept that combinations of different well-defined hiPSC-derived cardiac progenitor pools with timely-matched, native extracellular matrix from embryonic hearts will accomplish for the first time the realization of human heart organoids as 3D culture systems of developing heart structures. Clearly, BIOCARD will open game-changing opportunities for devising novel biomedical applications, such as human heart chamber-specific disease modelling, large-scale drug testing in appropriate human 3D cardiac bio-mimics, and regenerative cell therapie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'VitaminD3-Omega3-Home Exercise- HeALTHy Ageing and Longevity Trial'.

assistant: **Objectives**

As the European population is ageing rapidly, the growing number of seniors with age-related chronic diseases poses a challenge on European societies and health care systems. Therapeutic interventions that are effective, affordable and well-tolerated in the prevention of chronic disease are urgently needed and will have an outstanding impact on public health as a whole. Among the most promising interventions that meet these requirements are vitamin D, marine omega-3 fatty acids and physical exercise. However, their individual and combined effects have yet to be confirmed in a clinical trial. The DO-HEALTH will close this knowledge gap in a large 3-year multi-centre clinical trial that will establish long-term efficacy and safety data for the 3 interventions in the prevention of age-related diseases in seniors.The DO-HEALTH trial will enrol 2152 community-dwelling men and women aged 70 and older, when chronic diseases increase substantially. The randomized-controlled trial will test the individual and the combined benefit of 2000 IU vitamin D/day, 1 g of omega-3 fatty acids/day and a simple home exercise program in an efficient factorial trial design. DO-HEALTH will establish evidence in 5 primary endpoints: the risk of incident non-vertebral fractures; the risk of functional decline; the risk of blood pressure increase; the risk of cognitive decline; and the rate of any infection. Key secondary endpoints include risk of hip fracture, rate of falls, pain in symptomatic knee osteoarthritis, glucose tolerance, gastro-intestinal symptoms, mental and oral health, quality of life, and mortality. Follow-up will be in-person, in 3-monthly intervals (4 clinical visits and 9 phone calls). DO-HEALTH will further assess the comparative effectiveness of the interventions by evaluati