RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart Microbeads for a revitalised Gut' in the context of a Horizon Europe call.

assistant: **Objectives**

Functional gastrointestinal disorders (FGIDs) are a group of debilitating conditions affecting up to 40% of the global population, significantly impairing quality of life and driving up healthcare costs. Current treatments focus on managing symptoms rather than addressing the root causes of FGIDs, such as inflammation, increased intestinal permeability, and gut microbiome disruptions.The SMartGut project aims to develop innovative therapeutic microbeads that encapsulate probiotics within a photo-crosslinkable biopolymer-based core. To enhance functionality, SMartGut will employ the Layer-by-Layer assembly technique to create a nanoscale protective and bioactive coating on the therapeutic microbeads surface. This coating can incorporate antioxidants to reduce inflammation and improve probiotic adhesion in the gut, and targeted peptides to strengthen gut barrier function.The therapeutic microbeads will be evaluated for their structural, morphological, and physico-chemical properties, followed by assessing the release kinetics of the bioactive components of the therapeutic microbeads and the survival of the encapsulated probiotic strains in the intestine using a simulated gastrointestinal digestion test designed for both healthy adults and the elderly. This test will ensure the effectiveness of the therapeutic microbeads in reducing gut inflammation, restoring the microbiome, and reinforcing intestinal epithelial junctions to address FGIDs. Then, the therapeutic microbeads will be incorporated into food models to evaluate their stability and impact on food characteristics while preserving their bioactivity features after food storage.SMartGut has the potential to revolutionize FGID treatment by delivering a multifunctional therapeutic system that targets the core factors o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantitative analysis of geo-hazards in europe using underwater acoustics' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

This project aims at analysis high-resolution side scan sonar imagery recently acquired in the SW Iberian Margin (EU-funded HITS project). This analysis will consist in the systematic assessment of acoustic textures and derivation of seabed geophysical parameters. This will lead to a better understanding of geo-hazard potential of deep-sea areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sustainable Organisation between Clusters Of Optimised Logistics @ Europe' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The project aims to create an open European platform of excellence in the area of supply chain management and logistics in connection with hubs and gateways. Its purpose is to enable research-driven regional clusters throughout Europe to collaborate and exchange experiences for increasing sustainability and competitiveness of logistical services and (intermodal) transport operations. The consortium consists of five clusters that represent essential areas of logistics (deep-sea hubs, airports, land-hubs and short-sea hubs). In the project the needs of the stakeholders will be analysed, a strategy for international cooperation will be elaborated, and adequate plans for joint action will be initiated and implemented. In addition, training activities will be carried out. The project will pursue its objectives especially through extensive dissemination and exploitation activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Food in the Spanish and British Caribbean in the Nineteenth Century: Encounters, Exchanges, Identities'.

assistant: **Innovation**

This research project aims to compare the British and Spanish empires in the nineteenth-century Caribbean. More specifically, it focuses on the discourse  on food in the British and Spanish colonies. This project stems from my doctoral research. My aim is both to find a connection between the ways in which food and diet were perceived and discussed in the British and Spanish Caribbean colonies and to evaluate the differences in the discourse on food in the two empires, with the objective of analyzing colonial identities and imperial ideology in the Caribbean through the lens of food. My focus on food and diet sheds light on how encounters, negotiations, appropriations, rejections and interactions of culinary practices are more than just a matter of human nutrition but rather concern fundamental issues as the construction of identities, asymmetries of power, agency of the subaltern and mutual influences. The basic assumption of this project is therefore an analysis of the relationship between food, identity and power.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Decision Support for Integrated Crew and Aircraft Recovery on the Day of Operations'.

assistant: **Objectives**

The airline industry experiences growing congestion in the airspace over Europe, making problems more and more common and increasingly difficult to solve without causing new problems. Management of disruption occurring on the day of operation has therefore become an important issue for the airlines. This proposal aims at producing a decision support tool for the management of disruptions. The initial outcome will be a new way of organising the operations control at the airline, letting the organisation become an input to the demands of the decision support tool. The outcome from using the tool would be faster recovery from disruptions, better service to the customers, fewer delays, fewer costs for the airline, and less unnecessary flying due to disruption.Objectives:The main objective of the airline is to deliver the product and service the customer requests. The main objective of DESCARTES is to produce a holistic decision support tool for solving problems caused by disruptions in the airline operation on the day of operations, thereby facilitating the airline to meet their objective. A system of use for operations staff without scientific knowledge is a significant contribution, together with the immediate effects on methods of organisation and work in the airline planning divisions. The research performed within the project will be organised into solving use cases, each contributing to the generic knowledge on real-time optimisation problems.Work description:The project approach is to identify a number of key operational scenarios where disruption, for any of a number of reasons, can lead to a degradation in passenger service. Using these business scenarios, which will be categorised into minor, medium and major disruption, the business processes required to improve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Diffuson-related transport in ionically conducting solids' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In DIONISOS, we aim to develop new analytical relationships for ion- and heat-transport in ionicconductors, and thus heal significant inconsistencies of the current understanding. Currently ion- andheat transport are interpreted as unrelated phenomena; ion transport being based on local jumps,whereas heat transport being mediated by dynamic lattice vibrations called phonons.Among other studies, my pioneering works in the field of solid ionic conductors (J. Am. Chem. Soc.2017, J. Am. Chem. Soc. 2018) opened discussions about plausibility-gaps in state-of-the-artconcepts, in particular regarding interactions of phonons with mobile ions. Our work has shown thatby tailoring the lattice dynamics and vibrational properties of materials, the ionic transport can beaffected, which cannot be explained well by current models.To this end, we propose to analyze both ion- and heat-transport in several representative materials,designed for the purpose, to test our hypothesis that it is not a classical phonon phenomenon, butrather local vibrations, quantized by the diffuson, that dominate the heat and ionic transport in fastionic conductors.DIONISOS will thus provide an in-depth fundamental understanding of how local vibrational modesconnect thermal to ionic transport, and ideally a new analytical relationship. A unified understandingof thermal transport and ionic transport will pave the way for further research on how local structuralphenomena affect global materials properties. In addition, a theory of linking local ionic motion withlocal thermal motion will be of vast value for the design of high-performance functional materials.


**Keywords:** Diffuson thermal transport,  thermal conductivity,  ionic conductivity,  superionic conductors,  vibrational, characterization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mutation-driven immunoediting of human cancer?' (MUTAEDITING).

assistant: **Innovation**

It is well documented that each human cancer has acquired a large number of mutations (50-500), some of which are drivers for tumorigenicity, others of which are indolent passengers. It has also been established that such mutations can be recognized by the patient´s T cells via the presentation of mutated peptides on HLA molecules of a tumor cell. If such immune responses against cancer mutations are generally relevant for cancer development (according to Paul Ehrlich´s hypothesis), one can predict several consequences: 1) The spectrum of mutations found in an established tumor of a patient should be diminished for those that give rise to peptides presented by the HLA molecules of this patient, but not for peptides relevant for other HLA molecules. 2) In HLA-negative tumor cells, the spectrum of mutations (those that occurred after HLA loss) should no longer be dependent on the patient´s HLA molecules. 3) A cancer patient should have T cells against mutations that occurred at an early point in cancer development but that are no longer present in the tumor at the time of diagnosis because of negative selection of such tumor cells by the immune response. The aim of this proposal is to test the hypothesis by studying these three predictions in a large cohort of cancer patients treated at the University Hospital of Tübingen. Clinically relevant human cancer samples from several cancer entities will be tested for mutations by exome and transcriptome sequencing. Those mutations actually presented as HLA ligands will be analyzed by mass spectrometry, and the patient´s T-cell repertoire against mutations will be analyzed. The result of this research should be the confirmation, the rejection, or an amendment of the hypothesis. The outcome will be of decisive influence on the can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Assessment of environmental accidents from a security perspective'.

assistant: **Innovation**

Industrial accidents have repeatedly revealed the sensitivity of our environment to human negligience. Despite all efforts and advances in security and civil protection the habitat of human species remains vulnerable. The overall objective of this project is to increase the knowledge base needed to ensure the security of our natural environment. The project will analyse major industrial and environmental accidents from a security perspective using foresight methods and scenario building techniques. Natural phenomena (fires, floods), industrial accidents (chemical, biological and other) and other possible threats on a broad perspective will be investigated. The project will directly contribute to the implementation and planning of the Security theme of the 7th Framework Programme and it will also help shaping EU policies in related fields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Framework for the Analysis of Research and Adoption Activities and their Macroeconomic Effects' (FRAME).

assistant: **Innovation**

FRAME will develop a new generation of Dynamic Stochastic General Equilibrium (DSGE) models that will advance the state of the art by allowing for the first time realistic estimates of the impact of public research and innovation activities on innovation, productivity growth and unemployment.FRAME will begin by constructing a baseline model,which can be extended to address different policy issues. The baseline DSGE model incorporates important new features: it distinguishes between investment by companies in R&D and their investment in technology adoption; it allows public R&D and innovation activities not only to enhance the productivity of private R&D but also to facilitate the diffusion of technologies to private companies. FRAME will extend this baseline model to allow: multiple sectors; multiple countries; endogenous skills; and labour markets with search frictions and unemployment. These extensions allow us to investigate the effects of different policy interventions over the short, medium and long term. In addition to developing new models, FRAME will explore new approaches to estimate key model parameters, including: the elasticities of innovation with respect to private and public R&D; adoption lags; the elasticity of the speed of diffusion with respect to private adoption expenditures; and the elasticity of adoption with respect to public activities aimed at fostering the diffusion of new technologies to private companies. This last parameter will be estimated using a unique dataset combining information from firms on the introduction of new products with data on research contracts they have signed with the Fraunhofer Society. Public research and innovation activities have played a critical role in technological progress, yet we have little quantitative knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated molecular and cellular mechanotransduction mediated by protein p130Cas' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The sensing of force by cells is determinant for processes like morphogenesis, wound healing, or tumour formation, and can control functions such as proliferation, differentiation, or gene expression. However, the specific mechanisms by which cells sense mechanical forces and respond accordingly remain largely unknown. The proposed project aims to characterize cell mechanotransduction through the study of the Src family kinase substrate p130Cas (Cas, Crk associated substrate), a key protein involved in many cellular processes which is known to be activated (phosphorylated) by force. In the first part of the project, carried out at the outgoing institution, optical and magnetic tweezers and Total Internal Reflection Microscopy (TIRF) will be employed to examine how the phosphorylation of single Cas molecules is regulated by force. Individual Cas molecules will be stretched, and TIRF will be used to determine the force required for phosphorylation, if increased forces lead to increased phosphorylation (providing thus for a mechanism for the sensing of force magnitude), and if discontinuing the application of force leads to dephosphorylation (providing for a mechanism for the sensing of force interruption). In the second part of the project, which will take place mostly at the return institution, magnetic tweezers will be used to study force-dependent Cas phosphorylation in living single cells. The sensing of mechanical forces by cells will be analyzed by studying how these stimuli phosphorylate Cas locally at the site of force application, and globally through cytoskeletal force transmission. The role of the cytoskeleton in integrating local mechanical stimuli will be examined by modifying and measuring its mechanical state through micropatterning technologies. The intere
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Smart Energy Management System' (SEMS).

assistant: **Innovation**

Stignergy brings to the market a pioneering Smart Energy Management System (SEMS) based on bio-inspired Artificial Intelligence that intends to disrupt in the field of electrical efficiency and control for industrial consumers (which typically represent in EU more than 68% of all electricity consumed) with a drastic reduction in the demand and consumption of electrical energy, while facilitating the deployment of renewable energies. Its main benefits stem from (1) reducing up to 15% on the electricity costs, (2) decreasing the associated CO2 emissions (1.5%), (3) maximizing the self-consumption of green electrical energy (solar, wind)  locally produced, and (4) contributing to stabilize the electricity distribution networks for providers. To complement these benefits we propose two unprecedented features: (1) an Energy Storage Management module, which will maximize the self-consumption of green sources of energy from a Battery Storage Energy System and (2) a Smart Grid Integration module, which will provide a virtual charge to balance the energy demand/response of electricity providers. The existing control technologies do not include any intelligence to implement an efficiency energy plan, and are mainly focused on centralized tools which are difficult to install and entail high initial investment and labour costs. Besides, no solution enables to predict the peak demand and maximizes the self-consumption of local green electrical energy. To ensure the viability of SEMS we will assess its technical, commercial and financial feasibility and the IPR exploitation, and define our Business Plan so as to achieve the market uptake in the targeted European countries in 2020. SEMS is aligned with the goals of the EU Horizon 2020 WP for Secure, Clean and Efficient Energy and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synthesis and characterization of organometallic, paramagnetic tervalent titanium compounds and their role in catalysis' (1994-1998).

assistant: **Innovation**

Group 4, cationic complexes (Cp2MR)+A-(Cp=cyclopentadienyl, M= Ti, Zr, Hf; A= complex anion) are the last generation of very active olefin polymerisation catalysts. These and related complexes are expected to give full control of catalytic olefin polymerisation process at the molecular level and to lead to completely new materials on the basis of simple olefins. Of the active metals, titanium is for economic reasons most attractive, but the complication seems to be that the metal can have various, energetically not far different, oxidation states. Catalytic activity seems to be limited to cationic, four valent complexes according to knowledge obtained so far. The reason for this, is not clear at all. Neutral, tervalent titanium complexes Cp2TiR meet the basic criteria for catalytic activity. They have a Ti-C bond ready for insertion and a vacant coordination site suited to pre-complex and activate an olefin monomer. So far, no successful application of this type of compounds in catalytic olefin polymerisation has been described. From exploratory work by the Teuben group on Cp*zTiR derivatives it is known that olefins do interact with the metal center but so far insertion into the Ti-C bond and building of a polymer chain has not been observed. In the main part of the project we will concentrate on the question whether it is possible to modify the Cp2TiR system so that it becomes an active polymerisation catalyst. Various approaches will be tried out and some examples will be described in some detail below. 1) modification of the cyclopentadienyl ligands by varying the number and nature of alkyl substituents on the ring is a first target. Some exploratory research indicate that there is a dramatic change in reactivity when e.g. reducing the number of methyl substituents