RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Demonstration of improved dairy products through the application of starter strains of lactic acid bacteria with engineered fermentation pathways' (1994-1998).

assistant: **Concept**

Lactic acid bacteria have long been used for the preparation of a number of food products from vegetal and animal origins. Their role in food processing is two-fold: to ensure transformation and conservation through the production of lactic acid, and to bring flavour and taste either indirectly through the secretion or release of hydrolytic enzymes such as proteases, peptidases or lipases, or directly through the production of aromatic compounds such as acetaldehyde or diacetyl. For a long time, lactic fermentation has been achieved through artisanal methods relying exclusively on natural blends of strains propagated from batch to batch in the farmhouse. But the vast majority of dairy products put on the market today in Europe are produced in large, highly industrialized plants with a limited number of starter strains themselves produced industrially and marketed following sophisticated processing such as lyophilization. As a consequence, the dairy industry today relies on a limited number of acidifier starter strains with quite restricted organoleptic profiles, in contrast with the immense diversity of strains with rich taste and flavour potentials available from natural niches. Yet, the current trend is towards mild, sweet and aromatic dairy products. Our objective is to exploit metabolic engineering technology for the construction of improved dairy starters. Indeed, many starters are too lactic" in the sense that their fermentative metabolism is primarily channeled towards the production of lactate, and the resulting dairy products are too acid and lack taste. Metabolic engineering will allow re-routing of the carbon flux towards the production of secondary metabolises enhancing the organoleptic qualities of the product. Directed genetic modification offers the advan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Intra-tumoral heterogeneity in NRAS-driven metastatic melanoma' (INHuMAN), addressing dissemination and exploitation.

assistant: **Impact**

Metastasis is largely refractory to therapy and, thereby, responsible for 90% of cancer-related deaths. An incomplete view of the mechanisms that drive metastasis has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for metastatic patients. There is increasing evidence that this multi-step process involves reversible non-genetic reprogramming events allowing cancer cells to acquire diverse phenotypic features needed to migrate, invade, intra/extra-vasate and actively adapt to the varying environment (stress) they encounter. Understanding metastasis therefore requires methodologies that capture the magnitude and dynamics of non-genetic reprogramming in 4D (space and time) at the single-cell resolution. The advent of reliable single-cell multi-Omics analytical tools allows the simultaneous profiling of single cell’s genome, epigenome and transcriptome. Integrating single-cell profiling with lineage tracing provides a robust framework for defining cell fate transitions, intermediate states and trajectory inference. The host lab has recently used such a powerful combination of approaches to study the cellular origin of melanoma, the early molecular events associated with initiation of the disease and to portray cell state dynamics during therapy response. I propose to exploit this know-how to perform a longitudinal and exhaustive analysis of the diversity and trajectories of melanoma cell states during metastatic dissemination using a clinically-relevant mouse model of melanoma, a disease with a very high metastatic propensity. The gene regulatory networks underlying the identified metastatic cell states will be deciphered and the data exploited to develop therapeutic modalities targeting (amenable) drivers of state switching
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '2 real applications for requirements engineering' (2RARE) targeting Fourth Framework.

assistant: **Abstract**

2RARE addresses two large and complex distributed software-intensive heterogeneous systems where the precise specification of requirements is of key importance, as well as the evolution of these requirements over time and across different system families.- The first application is based on an infrastructure composed of satellites, ground stations and a network system for which a software intensive component (about 1 million lines of source code) has to be developed. The project, launched in 1990, is expected to finish by the end of 1996. It is characterised by an incremental development resulting in the successive delivery of three versions of the system. Each version has to encompass a large variety of change requests.- The second application is a distributed multimedia retrieval services system offering facilities to users via set-top boxes (connected to their TV sets) over the telephone network. In the first phase, the system will provide a simple video-on-demand service based on a single movie server. Later the application will be extended for multiple servers and more complex services (e.g. tele-shopping).The main objective of the 2RARE project is to deal with the changing requirements of these applications. Therefore, the project proposes to use a new generation of Requirements Engineering (RE) techniques to provide a rigorous specification of the requirements expressed by customers and of the system's analysis resulting from these requirements. Moreover, requirements traceability techniques will be applied in order to integrate and maintain the different kinds of descriptions captured during the RE activity.Emerging modelling techniques based on recent achievements from Esprit projects (IS-CORE, ICARUS and NATURE) will be used for handling the two applications. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design and engineering of the future generation Internet - Towards convergent multi-service networks' (EURO-FGI) targeting Sixth Framework.

assistant: **Abstract**

The main objective of the Euro FGI network is to develop and maintain the most prominent European centre of excellence in Future Generation Internet (FGI) design and engineering, acting as a Collective Intelligence Think Tank, representing a major support for the European industry and leading towards a European leadership in this domain.The FGI will offer multi-service/multimedia, mobility, service ubiquity and context awareness, convergence (services and fixed-mobile), Quality of Service, variable connectivity (always best connected), spontaneous networking and other capabilities as the norm.Technology diversity is growing fast and mastering such a heterogeneous environment becomes essential for network designers. This new environment makes obsolete the design and engineering methods and tools currently available and forces the scientific community to develop new principles and methods to design/dimension/control/manage the new multi-technology architectures. These architectures will provide seamless end-to-end connectivity by hiding the technology diversity from service developers and users.In addition, future high-speed wire-line and wireless access technologies provide instant high bandwidth connectivity making it difficult to forecast demand and thus to apply traditional traffic engineering methods.For addressing this new environment, Euro-FGI will strengthen the integration of the scientific community activities to fulfil two main goals:- Overcoming the challenge of technology diversity (vertical and horizontal integration) in the design of efficient and flexible FGI architectures- Providing innovative traffic engineering approaches adapted to the new requirements and developing the appropriate quantitative methods for analysis, simulation and measurementDue to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Smart motes for industrial and utility inspections' (SMarble).

assistant: **Innovation**

Pipe networks for both industry and utilties face a major replacement investment over the next decenium as many of these networks are reaching the age for which they where build. Without proper inspection techniques however we may be replace perfectly good pipes and leaving bad ones as we simply do not know their state. Industrial mixing tanks are heavely used in the proces industry and are a major energy user in plants as larger masses have to be brought into motion. Optimizing this proces could improve the quality of the mixing proces and lower the energy usage.Both cases would benefit from enhanced inspection methods and the floats from the Phoenix project are already making their way to these systems. Within SMarble we want to show that these inspections can benefit from more technologies from Phoenix. Phoenix floats are inserted in operational pipe and tanks and measure their own interal movement. After extraction this data is analysed and the results can be used for extracting information about both the process and the environment through which the motes move. The floats move have no propulsion or steering and thus essentially operate while the system is in normal operation. In the Phoenix project two additional technologies have been developed, ultrasound measurement for both ranging between motes and to walls, and, based on the ultrasound measurements, and modelling of the environment. In SMarble we want to create and show the business case for bringing these technologies to market. Through two pilots and market analyses we want to assess the technology, its economic and societal potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Human Embodied MultiSensory Development: An investigation of the construction of embodied multisensory experience in human infancy and early childhood' (HEMSDEV), addressing dissemination and exploitation.

assistant: **Impact**

We perceive our body and peripersonal environment through multiple sensory modalities. The distance receptors (e.g., vision and audition), provide information about stimuli in both personal and extrapersonal space. The direct receptors (e.g., touch and proprioception) provide information about the body and external stimuli impinging on the body. Having multiple modalities bestows advantages by providing complementary and independent sources of information about the environment and consequently makes our responses more efficient. However, integrating the senses across the body also presents computational problems for the human nervous system. For example, in order to locate in the visual field an object perceived through touch we must take account of the current posture of the body. In this application I propose a two-phase programme of research directed at investigating how infants and children develop multisensory representations of their limbs and bodies and stimuli impinging upon their bodies (embodied multisensory development). Phase 1 (years 1-3) will undertake a cross-sectional investigation into the developmental time-course of emerging body representations, utilizing a number of behavioural and physiological measures (EEG). The paradigms and findings of Phase 1 will then be used to inform the design of Phase 2 (years 3-5), which will investigate the causal drivers of developmental change in body representations at a behavioural and brain-systems level using a variety of longitudinal and clinical methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhancing recovery from eating and weight disorders using mHealth and psychological theory' (SmartEater) targeting Horizon 2020.

assistant: **Abstract**

Smartphones are ubiquitous in all age groups and socioeconomic levels and digitalization of various life domains is in fullprogress. While there are several areas where skepticism is justified, the personal health domain still holds high promises, particularly when applied in specific settings. The proposed mHealth app SmartEater provides intelligent mobile logging of stress, and eatingbehavior as a basis for intervention and follow-up care in clinics treating eating disorders and obesity. Current apps require frequent and cumbersome entries, resulting in low user adherence and poor data quality. Evidence for their usefulness is often missing. Further, therapeutic content is not personalized. In SmartEater, users repeatedly enter data on experienced craving for foods and stress. SmartEater then ‘learns’ from the user through sophisticated machine learning algorithms: data from smartphone usagepatterns (e.g. screen-on time, calls, messages, internet traffic) and sensor data (e.g. movement, background noise) arecombined to substitute for manual user input, thereby progressively reducing user burden. Temporal pattern analysis ofindividual time-series allows prediction of stress and craving bouts into the near future. Such predictions allows the app to respondto upcoming eating 'crises’ e.g. overeating/binge eating and launch situation-appropriate tips that have been developed individually for the user during in-patient treatment. SmartEater will be routed in psychological models of eating behavior and rigorously tested in the described population to evaluate efficacy. Due to the sensitive nature of such data, SmartEater enforces strict privacy protection. Targeted markets include health insurances which profit from improved patient health and successful transfer into daily
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Role of enzyme-coupled TRP channels in immune cell function' under Seventh Framework.

assistant: **Concept**

Low systemic magnesium (Mg2+) levels exacerbate pro-inflammatory diseases, suggesting a putative role of Mg2+ transport in immune system homeostasis. The Mg2+ and calcium (Ca2+) conducting transient receptor potential ion channel, TRPM7 has an indispensable, vital role in cellular physiology. TRPM7 regulates cellular and systemic Mg2+ homeostasis and is essential for immune cell differentiation, proliferation and survival. However, little is known about underlying mechanisms or the physiologic regulation of the protein’s channel or enzymatic domain. Autoimmune diseases are often accompanied by low systemic Mg2+ concentrations, which might be associated with altered TRPM7 function. Thus, it is important to identify whether TRPM7 represents a valuable new target for immune therapy. Antigen-presenting cells (APC) and T cells are pivotal regulators of immune system homeostasis. The intrinsic risk of potentially harmful autoreactive T cells is controlled centrally during selection in the thymus. Peripheral mechanisms to limit autoimmunity include immunosuppression through regulatory T cells (Tregs). In the last years Tregs received enormous attention as their deficiency provokes severe autoimmune disorders. The regulation of tissue homeostasis by APC is equally important to avoid unbalanced pro-reactive immune system responses. APC maintain tissue homeostasis via phagocytosis of invading pathogens and secretion of pro- and anti-inflammatory mediators. In this project we are planning an interdisciplinary approach combining biophysics with basic immunology to study the role of TRPM7 in APC and T cell function and in immune system homeostasis. We are going to use novel innovative tools to identify the physiologic role of the channel versus the kinase activity. This is particula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Silicate alteration in marine sediments:  kinetics, pathway, and dependency' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Over its long geological history, the overall habitability of Earth has been governed by the chemical alteration of silicate minerals, a reaction that buffers pCO2 and climate. While terrestrial silicate weathering is widely appreciated, marine silicate weathering and reverse weathering (or marine silicate alteration, MSiA, altogether), has long been considered insignificant in the big picture. This paradigm is challenged by recent work that suggests reverse weathering, as an oceanic Si sink, could be three times higher than previously thought. The latest estimates of marine silicate weathering showing its CO2-fixing capacity could be 82% of that of its terrestrial counterpart. Though potentially significant, these estimates are associated with large uncertainties and untested assumptions. In particular, information about the exact chemical pathway of MSiA, kinetics, and the environmental dependency is missing. To fill these gaps, I will provide the first comprehensive assessment of MSiA by quantifying its rates through both laboratory experiments and field observations. While the former constrains how MSiA initiates, the latter represents the million-year quasi-steady state condition in nature. Reproducing the conditions for MSiA in the laboratory is undeniably challenging due to the required multi-year incubation under up to 340  times atmospheric pressure and near-frozen conditions, which I can reproduce with a novel apparatus. Circulation of modified seawater with realistically slow flow will be maintained to derive MSiA rates through continuous fluid composition monitoring. Together with the rates estimated from field observations, I will evaluate the dependency of MSiA on environmental factors, such as the type/quality of silicates and organic matter. The project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Market Research for Oceanvolt zero-carbon emission marine electric propulsion system' in the context of a Horizon 2020 call.

assistant: **Objectives**

Oceanvolt has been growing with a CAGR of +475% during the last six years, the company aims to 60M€ annual revenueand to employ several hundred by the 2020. Oceanvolt’s products comprise a range patented marine electric motors, 24/7remote management and monitoring services and hybrid propulsion solutions. These have already been successfullydelivered to about 200 sailboats in 26 countries globally making it the undisputed market leader.There are approximately 1.5 million boats with small and medium diesel engines. Oceanvolt can replace the engines withelectric propulsion technology that is free of greenhouse emissions, lightweight, reliable and maintenance free. A keyrationale for businesses is the lower the Total Cost of Ownership of boats with electric propulsion due to decreasingmaintenance expenses, higher efficiency of electrical engines, thus directly affecting the cost of transportation and boostingcompetiveness. The environmental effect of this transformation is significant as it would reduce yearly CO2 emissions up to607 000 tons in early phases alone.The objective of the SME Phase 1 project is to conduct a feasibility study to investigate further suitable markets forOceanvolt electric propulsion technology beyond the current market in sailboats. New significant market potential could befound in small passenger boats, workboats and submersibles. Also there could be potential for licensing Oceanvolt’stechnology.The aim of the SME Phase 1 is to find 2-3 markets which have significant growth potential and which could be addresseddirectly with existing products or with minor modifications. The outcome includes a specific go-to-market plan, legal andregulatory landscape and freedom-to-operate analysis. The target is to have sales in the new markets in 12-18 months f