RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Steering and radiation effects in oriented crystals and their applications implementation into Geant4' to be submitted under Horizon 2020.

assistant: **Abstract**

Crystalline structure is a unique environment for strong-field QED effects involving both high-energy charged particles and photons. A small piece of crystal material could be used as an intense source of X- and gamma-ray radiation, a positron source, a beam manipulation instrument, a compact detector and a compact wake-field accelerator as well. Consequently, a crystal could be useful for a wide range of applications in accelerator physics, high-energy frontier physics, nuclear physics, cosmic-ray detectors, dark matter search and radiation therapy.The implementation of both physics of electromagnetic processes in oriented crystals and the design of specific applications of crystalline effects into Geant4 simulation toolkit as Extended Examples to bring them to a large scientific and industrial community and under a free Geant4 license is the main goal of the project.The implementation of the following innovative applications into Geant4 will be mainly focused on:1. Crystalline deflector to extract a charged particle beam from an accelerator (electron synchrotron, hadron collider) to supply fixed-target experiments by an intense low-emittance beam.2. Crystalline source of intense coherent hard X-ray and gamma radiation, crystalline undulator.3. Crystal-based hybrid positron source for both linear and circular e+e- colliders (ILC, FCC-ee) as well as for muon colliders.The outgoing research phase of this MSCA-GF project at the Korea Institute of Science and Technology Information as well as training at Korea Advanced Institute of Science and Technology and University of Science and Technology and participation in high-tech Daedeok Innopolis exhibitions will bring the ER to a considerably higher level of competence. During the incoming phase at INFN Division of Ferrara su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular mechanism and inhibition of extracellular vesicle-mediated PD-L1 release in melanoma cells' (2014-2020).

assistant: **Innovation**

Harnessing the power of the immune system to treat cancer has long been a sought after goal of oncological research. Immune checkpoint inhibitors, such as anti-programmed death receptor 1 (PD-1) blockade therapies, have now taken center stage. However not all patients respond, highlighting gaps in our understanding of the mechanisms of tumour immunosuppression. Upregulation of the PD-1 ligand (PD-L1) on tumour cells initiated this therapeutic direction, yet it is becoming clear that the modality of PD-L1-mediated immune suppression is not limited to the plasma membrane. Like many tumor cells, melanoma cells secrete small extracellular vesicles (EVs) with pro-tumorigenic properties. Melanoma EVs express PD-L1 that suppress T cell function and facilitate tumour growth in pre-clinical mouse models. This systemic mechanism is clinically relevant, as circulating EV-PD-L1 levels can stratify anti-PD-1 clinical responders from non-responders. Thus inhibiting EV-PD-L1 may increase anti-PD-1 efficacy and broaden the responder bracket. One plausible strategy would be to block tumor EV secretion, yet little is known about the molecular mechanisms that drive PD-L1 loading and release. Herein, I intend to uncover the molecular mechanisms of EV PD-L1 release from melanoma cells using state-of-the-art optical and bioluminescent reporters to reveal novel druggable targets. This basic knowledge will be exploited to guide subsequent inhibition, through a drug screen for candidates that inhibit EV-PD-L1 release and restore T cell function. Ideally the outcome of this in vitro study will provide a strong rationale for combining anti-PD-1 agents with inhibitors of EV-PD-L1 secretion, to be tested in pre-clinical mouse models. If successful, melanoma EV blockade may remove the unanticipated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'New Frontiers for Optoelectronics with Artificial Media'.

assistant: **Objectives**

To detect or generate complex light beams that are increasingly needed in biology and photonics (light with non-zero angular momentum and non-classical light), it is necessary to rely on bulky and sophisticated setups, considerably limiting their potential. The FORWARD project aims at obtaining the same functionalities with a new generation of optoelectronic components of submicron thickness in the near infrared range. This ambitious objective implies to devise radically new ways of creating and manipulating complex light at the nanoscale. In FORWARD, this tremendous challenge will be addressed by hybridizing two classes of artificial media-colloidal quantum dots (CQDs) and metamaterials-and leveraging advanced cooperative behaviours within the hybrids. In the new devices, which will be pumped electrically, the active layers will be made of a film of CQDs interwoven with the metallic inclusions of an optical metamaterial.FORWARD has a strong multidisciplinary character as it lies at the crossroads of nanocrystal processing, nanofabrication, nanophotonics, condensed matter physics and optoelectronics. First, we will hybridize metallic metamaterials and CQDs, study the transport properties in these devices and develop metamaterial/CQD photodetectors demonstrating the advantage of the hybridization. Second, we will induce classical cooperative effects between the different metamaterial inclusions and utilize this approach to fabricate hybrids LEDs capable of emitting optical vortices. Last, we will induce quantum synchronizations among the CQDs and demonstrate hybrids LEDs that produce coherent and non-classical light.Each demonstrator of the project will be a world first in terms of functionalities, miniaturization and operation principle. Besides, this initiative can be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Protease Profiling and Triggered Drug Delivery for Personalized Cancer Therapy'.

assistant: **Objectives**

Proteases are involved in all hallmarks of cancer and are key regulators of tumor progression. The difficulties to monitor protease activity in vivo with sufficient sensitivity and selectivity make development of protease targeting cancer drugs and implementation of protease activity as a diagnostic and prognostic biomarker very challenging. The aim of PROTECT is to develop a novel comprehensive protease activity profiling platform for cancer-associated extracellular proteases that can address the main limitations of current strategies for in vivo protease activity monitoring with the ambition to enable a dramatic increase in sensitivity and multiplexing capabilities. We will design Liposomal Activity-Based Sensors (LABS) that can amplify proteolytic cleavage by triggering release of liposome encapsulated synthetic biomarkers. We will further leverage the possibilities to extract tumor specific protease profiles for development of personalized protease-triggered liposomal drug delivery vehicles (PROVES) for precision medicine.   Sophisticated protease-responsive membrane active peptides (proMAPs) will be developed to couple protease activity to biomarker and drug release. Methods to correlate biomarker release patterns to protease activity profiles in 3D breast cancer models will be explored.  The PROTECT platform can then rapidly be repurposed for precision drug delivery. The PROVES concept will combine the excellent properties of liposomes for drug delivery and the optimal combination of proMAPs, based on the protease activity profile retrieved from the LABS, for optimized protease-triggered liposomal drug release. Combined, the LABS and PROVES concepts represent a unique and comprehensive platform for diagnostics and personalized cancer therapy. The proposed work goe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Challenging the KNDy Hypothesis Using CRISPR-Cas9 Genome Editing: Evaluation of the Role of Neurokinin B and Dynorphin in Kiss1 neurons in the Control of Fertility' to be submitted under Horizon 2020.

assistant: **Abstract**

The function of the hypothalamic-pituitary-gonadal (HPG) axis is mastered by the hypothalamic neuronal population producing gonadotropin-releasing hormone (GnRH), which regulates LH and FSH secretion by the pituitary. Perturbations of fertility, e.g., in polycystic ovarian syndrome (PCOS) and hypogonadism associated with metabolic disorders, are related to functional alterations in the neuronal networks controlling pulsatile GnRH secretion. Recently, a neuronal population in the hypothalamic arcuate nucleus (ARC), which synthesizes kisspeptins (Kp; products of the Kiss1 gene), has been identified as an essential element in the regulation of pulsatile GnRH release. This ARC Kiss1 neuronal population co-expresses the neuropeptides, neurokinin B (NKB; encoded by Tac2) and dynorphin-A (Dyn; encoded by Pdyn); the term KNDy (for Kiss1, NKB & Dyn) has been coined to name this population. Different studies have pointed out the reciprocal stimulatory and inhibitory roles of NKB and Dyn, respectively, in the control of Kp output, which seemingly play a crucial role in the control of GnRH pulse generation. However, the relevance of such NKB/Dyn interplay in the dynamic control of GnRH release in different (patho)-physiological conditions, and whether this is fully dependent on Kp signaling, has not been fully clarified. We propose here to apply for the first time somatic genome editing of Tac2, Pdyn and Kiss1 loci in KNDy neurons, by using the CRISPR/Cas9 technology and virogenetic tools in suitable genetic mouse models, to address the physiological roles of NKB and Dyn in the dynamic control of GnRH neurosecretion, and their dependence on Kp signaling. The studies outlined in this proposal will substantially advance our understanding of basic neuroendocrine mechanisms for the con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Web Solution for the remote presence in Exhibitions and Showhouses' to be submitted under Fifth Framework.

assistant: **Abstract**

Efforts for the creation of virtual fairs have so far concentrated on the development of a wholly virtual environment, which is effectively an enhanced catalogue. What differentiates eFairs to other virtual fairs is that it complements the actual live exhibition or showhouse rather than replacing it, requiring a minimal customisation effort for each installation. The eFairs project promotes an innovative environment for the interaction between exhibition organisers and showhouse suppliers, with visitors and clients respectively, by integrating the communicative power of the Web with the potential of interactive video. Using the omni-directional panoramic video technology eFairs gives every user the possibility to control individually the desired point of view to the scene. Instead of using mechanical pan-/tilt-/zoom cameras that would only allow one user at one time to control the camera image, the eFairs viewer applies a special mirror technique that allows 360-degree video at one shot. This means that even during a live streaming every user can choose his point of view individually since panning tilting and zooming is done by the eFairs-software and not by the camera. In the area of video interaction, the project aims to link the well-understood electronic catalogue paradigm with the images delivered by a web-camera. In particular, the user must be able to directly click on an object in the image and receive the appropriate information associated with this object and stored in the electronic catalogue.For this purpose eFairs uses a static environment where hyperlinks are manually predefined as well as an experimental dynamic approach where Content Based Image Retrieval (CBIR) technology combined shape extraction methods is used to dynamically identify objects in the v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Customized Intelligent Life-Inspired Arrays' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Sensory systems based on arrays of hairs occur widely in nature and function in diverse sensing scenarios, for instance in air (cerci, external sensing hairs in arthropods), in water (lateral line, neu-romasts in fish) and in a fluid-filled compartment coupled to air through impedance matching de-vices and beamforming baffles (mammalian auditory apparatus). These mechanosensor-systems are amongst the most sensitive sensors known. This suggests that hair-based sensing organs, supported by appropriate neuronal representation and processing, are a model system particularly well-suited for studying the extraction of significant information from noisy environments. The twofold objective of the CILIA project is to identify the common principles underlying this wide-spread use in nature of arrays of mechanical sensory cells for the extraction of significant informa-tion and to make those principles available for design of engineered systems. Because organisms and their environments form tightly coupled interacting systems in which all components environ-mental characteristics and dynamics, sensory and physical morphology, peripheral and central neural processing and behavioural patterns play a significant role this analysis will be carried out at three levels simultaneously: the morphology and mechanics, the neuronal process-ing, and the behavioural strategies of the model-systems. Extraction of significant information is considered an emergent property from processing going on at all three levels. The model systems will be the cerci of crickets, the lateral line system of fish and the auditory system of bats. Knowl-edge gained from a representative sample of species and individuals from a large phylogenetic and ontogenetic range will be used to formulate design rules for man-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Cracking the Pitch Code in Music and Language: Insights from Congenital Amusia and Autism Spectrum Disorders'.

assistant: **Concept**

Music and language share similar properties and are processed in overlapping brain regions. As a common information-bearing element in music and language, pitch plays an essential role in encoding musical melodies, signifying linguistic functions, and conveying emotions through music and speech. However, two distinct neurodevelopmental disorders, congenital amusia (CA) and autism spectrum disorders (ASD), affecting millions of people in Europe and worldwide, may selectively impair individuals’ ability to process musical, linguistic, and emotional pitch. To date, it remains unclear why individuals with CA and ASD exhibit significant differences in music, speech, and emotion processing. Under our Delicate Form-Function Balance Hypothesis, we will conduct a series of behavioural and neurophysiological experiments to test the central hypothesis that normal musical, linguistic, and emotional functioning requires a delicate balance in the encoding and decoding of form and function in musical, speech, and emotional communication, with musical communication centred on form and linguistic and emotional communication focused on function. Most critically, we hypothesize that the differences in music, speech, and emotional processing in CA and ASD are rooted not only in pitch and cognitive abilities, but also in the balance between form and function for each domain. Addressing three specific aims regarding the impacts of cognitive processing styles, pitch processing skills, and language background (tone vs. non-tonal) on the behavioural and neurophysiological characteristics of music, language, and emotion processing in CA and ASD, this research will not only help reveal the underlying mechanisms of the two defining aspects of human cognition, music and language, but also form a la
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MAgnetically steerable wireless Nanodevices for the tarGeted delivery of  therapeutIc agents in any vascular rEgion of the body' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The past decade has seen exciting progress in the field of mobile magnetic small-scale devices. These tiny machines have demonstrated great potential for biomedical applications. However, current mobile micro- and nanodevices do not meet the conditions for their translation into medical practice. The use of these devices in clinical settings implies specific requirements and constraints that are often conflicting and imply substantial challenges that are not considered in lab-scale research. The ANGIE project puts forward a radically new technology that is far beyond the current state of the art in the field of micro/nanorobots, and implies major progress in small-scale robotics, magnetic navigation systems, and localized targeted drug delivery. ANGIE will create a solid baseline of knowledge and skills for localised targeted drug delivery based on steerable wireless nanodevices, capable of navigating the body vascular system to deliver drugs where no other instrument can go. ANGIE will offer health professionals vastly improved intervention capacity to tackle multiple chronic diseases and enable them to deliver drugs precisely where needed, with minimal side effects. To assemble the interdisciplinary communities around this technology and to demonstrate its potential to mitigate the impact of chronic health conditions, we will apply the ANGIE technology for the localized treatment of thrombotic stroke. ANGIE is supported by stakeholders representing a broad spectrum of European organizations and citizens, such as large multinationals (e.g. Siemens and CLS Behring), policy makers (e.g. health systems and healthcare facilities), as well as civil society organizations (e.g. associations of health professionals and stroke patients). These stakeholders will help us create a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The social context of advertising consumption' (SCADCO) under Sixth Framework.

assistant: **Objectives**

In modern market economies advertising plays a pivotal role in reflecting and shaping consumer culture. Understanding advertising consumption is therefore an important goal of social scientists. This proposal is positioned at the intersection of marketing, consumer research, sociology and social psychology and describes a research project on the influence of social context on responses to advertising messages.The proposal focuses on the role of emotional processes and in particular of embarrassment on consumer response to advertising messages. Currently there is no research on the causes and consequences of embarrassment in an advertising setting. In this research proposal I introduce a new theoretical construct that I define as embarrassment without agency to distinguish it from the notion of embarrassment typically investigated in sociology, social psychology and marketing.The key notion put forth in this proposal is that individuals can experience embarrassment even in contexts of low agency, that is i n situations where no recognizable responsibilities for the occurrence of the embarrassing episode can be attributed to the individual (e.g., when an individual experiences embarrassment as a consequence of passive or innocent exposure to embarrassing advertising messages).The aims of the projects are to understand(1) the conditions under which individuals may experience embarrassment during advertising viewing, focusing in particular on the role of social context;(2) the psychological causes of such embarrassment; and(3) the coping strategies that this emotional reaction can trigger, with a special focus on behavioural and cognitive (e.g., memory) consequences.The research proposal is designed to help European organizations from a variety of sectors to enhance their e