RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DATA REPOSITORIES AND COMPUTATIONAL INFRASTRUCTURE FOR ENVIRONMENTAL AND CLIMATE STUDIES IN THE EASTERN MEDITERRANEAN' under Seventh Framework.

assistant: **Concept**

The Mediterranean and Middle East, with a combined total population of more than 400 million people, are characterized by strong environmental gradients, climate extremes and diverse economic, social and cultural identities. It is expected that throughout the 21st century the region will experience substantial adverse climate changes and face major challenges in energy demand and supply, as well as a decreasing availability of fresh water. It will be essential to address the undesirable economical and societal consequences and manage them cooperatively. Rethinking energy and water policies and adopting new concepts to respond to these challenges are increasingly recognized as a high priority, both regionally and internationally. The main objective of the project is to favor and prepare the creation of a regional data infrastructure devoted to climate, water, energy and related topics, by engaging relevant entities into a coordinated effort at the regional scale. To this end the project will set up a Task Force including internationally recognized experts and carry out studies of all relevant scientific, technical, legal and political issues. It will also carry out networking activities aimed at regional climate stakeholders (Research institutions, public authorities, relevant state agencies, NGOs, etc.), in order to raise their awareness and engage key actors into creating the appropriate conditions for the formation of a regional data infrastructure devoted to climate, energy and water related data, and into capacity building, prospective & incubation activities for future collaborative climate research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Inductive logic programming ii' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The general aim of ILP is to develop theories, techniques and applications of inductive learning from observations and background knowledge in a first order logical framework. This project aims at continuing the ILP 1 project in which several significant research results have been obtained. To close the gap between conceptual work and applications, the consortium has identified four key areas where ILP technology has great potential. These areas are (1) natural language processing, (2) data mining and discovery, (3) design and configuration, and (4) data-base design. End-users active in these areas have been united in a users club and collaborate in the project by providing relevant test data. Based on an analysis of these four application domains, 14 scientific problems in need of substantial progress have been identified and organized around 4 themes:- Background knowledge / Techniques are needed that:-can handle large numbers of background predicates (Relevance),-can update theories structured in many levels (Revision),-can carry out predicate invention in deep-structured theories (Invention)- Complex Hypotheses / Techniques are needed that:-can learn deep structured theories and optimise the choice of a set of clauses for a single predicate (Multi-Clause),-can handle long chains of relevant literals, connected by shared variables (Deep),-can better handle recursive hypotheses (Recursion),-can search efficiently in the presence of structural concepts expressed in complex clauses (Structure).- Built-in semantics / Techniques are needed that:-better handle numbers (Numbers),-can express probabilistic constraints and definitions (Probabilities),-can learn and use constraints (Constraints),-work more efficiently through the use of built-in predicates and algorithms (Buil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'On-chip cell handling and analysis' (CELLCHECK), addressing dissemination and exploitation.

assistant: **Impact**

Despite its increasing importance in the pharmaceutical and cosmetic industries, the field of automated cell analysis to this day and age is still at its infancy. In order to deploy robust cytoanalytical systems with a high potential for parallelization, thus allowing their employment in high-throughput screening systems, sensor& microsystem technology and biotechnology must inevitably join forces. Both disciplines have undergone significant progress during the past decade. Cooperation has, however, often been hampered by fundamentally differing approaches towards problem solving (hardware top-down versus biochemistry bottom-up).Within the proposed Research Training Network, specialists from several disciplines will work together with the objective of developing novel integrated cell measurement systems and techniques. Single cell response to chemical and electrical stimuli, and intercellular communication between surface-attached cells under accurate control of the cell environment by micro-fluidic techniques, as well as suspended single cell analysis in micro-fluidic flow-through systems, where mechanical (cell size, shape, viscosity), optical (transparency), electrical (conductivity, permitivity) and biochemical properties are acquired, will be studied. Applications of this work are found in disease research, cell separation, cell culture control, and toxicology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Light in moving media' (MOLIGHT).

assistant: **Concept**

The interaction of light with matter is traditionally studied in media that are either still or moving at a negligible fraction of the speed of light. In this regime standard text-book results apply. However, if the medium or, more generally speaking, certain parameters that distinguish the medium such as the refractive index are made to change or move close to the speed of light then new and unexpected scenarios emerge. For example, if the medium refractive index is not moving but is made to oscillate at high, e.g. optical frequencies, then a parametric interaction occurs with an incident light beam amplified transformed into a new pair of light beams. If closed within cavity mirrors, amplification by the oscillating medium is enhanced and even vacuum photons are be excited in correlated pairs in a process analogous to the dynamical Casimir effect. We will also consider the opposite regime in which the refractive index profile does not oscillate but is made to move forwards close to, or even faster than the speed of light. Again we encounter surprising effects: light propagating in such a moving medium finds an elegant description in terms of a space-time metric in which space is flowing in much the same way in which water flows in a river or in which space flows in a gravitational field. Under appropriate conditions the analogy can be extended to black holes and the analogue of an event horizon for light is formed by the perturbation. Light is frequency shifted at the horizon and is also amplified: the horizon acts as a parametric amplifier. The perturbations required for these and other related effects described in the proposal will be experimentally obtained using intense laser pulses and nonlinear optics and thus open a fascinating new area of laser physics.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Splicing Fidelity: Enforcement, Modulation and Impairment.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In eukaryotes, the spliceosome removes non-coding introns from precursor messenger RNAs during pre-mRNA splicing. Crucially, many pre-mRNAs are spliced differently depending on cellular status or external stimuli. This “alternative splicing” reshapes the genetic information from a given mRNA to encode several protein isoforms and greatly diversifies proteomes.Splicing must be extremely precise as errors produce aberrant mRNA encoding potentially toxic proteins. Splicing fidelity relies on the accuracy of the spliceosome that assembles de novo on each pre-mRNA in a cotranscriptional manner, gets activated and selects the precise boundaries of introns to catalyse their excision. The spliceosome is endowed with two apparently conflicting properties: it must be very accurate to avoid splicing errors while being tolerant to accommodate alternative splicing changes. I. aim to unveil the molecular basis of splicing fidelity’s enforcement and modulation by the spliceosome.Due to its extreme complexity, the spliceosome has long been a major challenge for molecular and structural investigations. Recent progresses in cryo-EM allow the structural analysis of very dynamic and low-abundance biological objects such as spliceosomes. Hence, it is now possible to explore the most elusive aspects of RNA splicing, provided that the biochemical challenges of trapping and stabilising transient spliceosome intermediates are overcome beforehand.I will use innovative methods to capture spliceosomes from cell extracts and cryo-EM to investigate how splicing fidelity is:•enforced by molecular checkpoints during spliceosome activation•maintained/modulated by other cellular processes•impaired during viral infectionThe outcome of this research will bring us closer to answering a fundamental question
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Founding a Global Image Data Ecosystem', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Digital image data is a crucial part of biological research, fueling an exponentially growing body of research output. A surge in volume and diversity of bioimage data, owing to the fast developing imaging technologies, has brought to light many challenges including in sharing open image data. Resource owners, research infrastructures as well as grass-roots communities are actively tackling these challenges by developing file formats, ontologies, metadata models, to ensure that shared data is in line with the FAIR principles. However, many of these solutions remain regional and a global coordination effort is necessary to enable seamless image data sharing. This project will lay the foundation for a Global Image Data Ecosystem (GIDE) that connects different biological and biomedical image data resources across the globe to allow metadata and data sharing. GIDE will bring European research infrastructure and image data resource owners together with their counterparts from Australia and Japan to develop the basis of image data sharing. These interactions can then be used as a blueprint to engage with the wider global bioimage data community while strengthening the position of European infrastructures in the landscape. To enable partner resources and research infrastructures to communicate in one language, coordinated technical development towards use of harmonised imaging ontologies and metadata models will be carried out. Proof of concept implementations using harmonised image data and metadata will showcase the project developments and encourage adoption of these recommendations globally. These developments will also lay a crucial and strong foundation to build a future federated image data ecosystem on. Together, global efforts towards GIDE will provide a necessary fra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Feeding and hiding the monster: triggering and obscuring the central engine of active galaxies' (2007-2013).

assistant: **Concept**

Some of the most important open questions in astrophysics concern how and when active galactic nuclei (AGN) are triggered, and how important they are in the evolution of galaxies.In order to understand these processes and interpret the results found for AGN at cosmological distances, it is fundamental to account for the structure of their central engines in the local universe. This includes the unifying torus, whose properties are still uncertain. Thus, the first objective of this proposal is to characterize the AGN obscuring torus using an infrared survey of a homogeneous sample of nearby active galaxies. We will use mid- and far-infrared data obtained with the CanariCam instrument on the 10 m Gran Telescopio Canarias (GTC) and the Herschel Space Observatory, respectively. This survey will represent the definitive characterization of the AGN torus in the local universe. In addition, we will use new spectropolarimetric observations of a smaller sample of Seyfert galaxies to test the validity of the clumpy torus squeme, and ultimately, of the unified model for AGN.The second objective of this proposal is to confirm the hypothesis that AGN of different luminosities are triggered in different ways, with galaxy interactions triggering luminous AGN (quasar-like), and secular processes (bars or disc instabilities) triggering lower luminosity AGN (Seyfert-like). We also aim to investigate the role of other factors such as the environment in the triggering of the nuclear and star formation activity, and the connection between them.The results of the proposed project will substantially enhance our understanding of the physics of AGN and their role in galaxy evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ESTABLISHMENT OF A CENTRE OF EXCELLENCE FOR STRUCTURE-BASED DRUG TARGET CHARACTERIZATION: STRENGTHENING THE RESEARCH CAPACITY OF SOUTH-EASTERN EUROPE' to be submitted under Seventh Framework.

assistant: **Abstract**

SEE-DRUG’s Major Aim is to strengthen and broaden the scientific reach and socio-economic impact of the University of Patras (UPAT) through the creation of a Regional Centre of Excellence for Structural Biology that emphasizes the characterization and development of bioactive molecules with therapeutic potential.SEE-DRUG takes advantage of UPAT’s pivotal strength and growth potential of Structural Biology and combines it with high-quality, multidisciplinary scientific expertise in Chemistry, Pharmacology, Biology & Bioinformatics.  The SEE-DRUG project will enable: (a) the Protein Production group to efficiently produce and characterize protein drug-targets for structural analysis and drug development efforts, (b) the Structural Biology group to perform high-resolution structure determination, through time- and cost-effective NMR-based, cutting-edge techniques, and (c) the Pharmacology group to characterize lead therapeutic molecules in a comprehensive array of in vitro, ex vivo and in vivo systems.The long-term benefits of SEE-DRUG implementation will manifest on 3 levels: (a) the pooling of scientific expertise & the upgrading of infrastructure within UPAT, (b) the optimal integration of UPAT’s Structural Biology in ERA through the establishment of long-lasting partnerships, (c) the creation of a solid scientific platform that will become a pole for therapeutic biomolecule-oriented Structural Biology in Greece and in SouthEastern EU, and (d) the exchange of expertise (via twinning actions with 8 EU partnering organizations) and the building of networks with other scientists and technology end-users at a regional or local level, including the bio-pharmaceutical industry. Last, but not least, such a state-of-the-art Centre will create a number of positions for highly sk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling.' (NeoPur), addressing dissemination and exploitation.

assistant: **Impact**

Newborns are predisposed to an increased risk of developing seizures following brain injury higher than in any other moment in a person’s life. Data from experimental models and patients suggest seizures in neonates may cause increased mortality and a higher risk of adverse neurological outcomes including cerebral palsy, developmental delay and intellectual disability. Consequently, the long-term health costs associated with seizures and neonatal brain damage are very high. To date, both diagnosis and treatment of neonatal seizures remain a clinical challenge with seizure misdiagnosis estimated to be as high as 50% and only every second patient responding to current therapies. The ATP-gated P2X7 receptor, a gatekeeper of inflammation, has recently emerged as a promising target for seizure control, showing anticonvulsant and disease-modifying properties in animals. New data produced by the supervisor now also suggest a role for P2X7 during seizures in neonates. However, to bring P2X7 further towards a clinical application, we need evidence of seizure-induced release of ATP in the brain, we must determine what are the clinical outcomes of a genetic and pharmacological targeting of P2X7 during neonatal seizures and we must identify biomarkers to better identify patients suffering from seizures. NeoPur brings together a team of experts in purinergic signalling, industrial partners developing novel P2X7 antagonists and diagnostic devices and clinicians specialised in neonates. This highly interdisciplinary and intersectoral approach will add a significant contribution to the understanding of purinergic signalling during neonatal seizures providing novel diagnostic and therapeutic approaches. The skills acquired during the research project, the excellent training record of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Automated computer based lay planning and interface to leather cutting for footwear smes' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The aim of this project is to develop, for leather shoe upper parts, an automated lay planning system which will be interfaced to manual cutting system and offers scope for linking to numerically controlled cutting systems. It will be computer-based, targeted specifically at the requirements of SMEs and aimed to cope with their typical product mix, shoe order quantities, size distributions and range of materials. The project is particularly relevant to the SMEs. It brings pre-planning and computer technology into the traditional area of leather cutting. The benefits of a successful conclusion to this project will be a reduction in manufacturing costs through improved material utilisation. Better productivity through shorter training periods for operatives and an improved man/machine interface through modernisation of the workplace. The approach will also lead to improved consistency of product by enhancing the skills of poorer operatives. Upper leather accounts for up to 40% of the cost of a shoe and a substantial proportion of the leather skin ends up as waste on the cutting room floor. It is an expensive material and a small improvement in the utilisation of the material can make a large improvement in the overall profitability of a footwear manufacturer. Traditional leathercutting is a manual process involving a hand positioned knife and a press. There is no pre-planning before cutting and the results are dependent on the skill of the operative. In this project we are proposing a means of automatically laying out and interlocking complex pattern pieces with varied requirements onto a leather skin; giving consideration to the size and shape of the skin, its directional properties and any flaws in the leather. The main innovation lies in the proposed use of fuzzy logic