RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Targeting BET Bromodomains in Cancer –Mechanisms of Sensitivity and Resistance'.

assistant: **Objectives**

Besides DNA mutations, cancers harbor complex aberrations of the epigenetic landscape, which are reversible and amenable to pharmacologic intervention. Therapeutic targeting of chromatin regulators has shown great promise in first clinical studies, and this has triggered a massive effort to explore this machinery in academic and pharmaceutical research. Recently, the bromodomain and extraterminal domain (BET) containing protein 4 (BRD4), a reader of histone-acetyl marks, has emerged as a promising therapeutic target, and newly identified small-molecule BET inhibitors have shown impressive effects in preclinical cancer models. Unlike most established drug targets, BRD4 is typically not mutated or overexpressed in sensitive cell types, yet different cancer contexts show vast differences in their sensitivity to BET inhibition. This suggests that cancer cells can become “non-oncogene addicted” to BRD4. However, the mechanistic basis for this phenomenon remains elusive and so far no biomarker could be identified for predicting the sensitivity or resistance to BET inhibition. Moreover, preliminary results in an AML mouse model suggest that cells can rapidly become resistant to BRD4 inhibition, most likely through an epigenetic mechanism. This project will use an innovative approach combining proteomic profiling, advanced RNAi technologies and experimentally tractable mouse models of cancer to systematically identify and functionally characterize molecular determinants of sensitivity and resistance to BET inhibition. Advancing this mechanistic understanding will not only be critical for the further development of BET inhibitors in the clinic, but may reveal other key players that might be interesting as complementary or alternative target molecules. We believe that this study
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Knowledge Graphs for Stratigraphy' (StratiGraph).

assistant: **Innovation**

StratiGraph (Knowledge Graphs for Stratigraphy) aims to transform archaeological and paleontological documentation by developing innovative open collaborative tools that integrate advanced knowledge graphs, artificial intelligence, and 3D field documentation techniques. The project's ""Data-Ready"" approach enables clean, structured data collection during fieldwork for seamless integration into knowledge graphs without additional curation burden. Key innovations include tools that function effectively in all conditions - a ""works-everywhere"" solution allowing technology use even where power and connectivity pose challenges. The project will validate these tools through diverse case studies including the Basilica Iulia in Rome, Sarmizegetusa Regia in Romania, St. John Lampadistis Monastery in Cyprus, the Colonia Iulia Ilici Augusta in Spain, the Kraków Spadzista Palaeolithic site, the Santa Olalla site in Spain, and the dataset from Cesarea in Israel.StratiGraph will deliver: -Knowledge graph infrastructure to organize stratigraphic and spatial data-AI-powered tools for creating and enriching annotated bibliographies-Advanced 3D documentation capabilities for recording stratigraphy-Variable connectivity protocols for real-time and seamless offline/online work-Comprehensive training modules and technical support resourcesThe project emphasizes open science principles, with all tools being open-source and data FAIR-compliant. Through integration with the ECCCH, StratiGraph will establish new standards for digital documentation while fostering a skilled, collaborative research community across Europe. This will significantly reduce the time from discovery to publication while improving documentation accuracy and interpretation of our shared cultural heritage. By maintaini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Sectoral emission reduction potentials and economic costs for climate change'.

assistant: **Objectives**

The objective of the proposed work is to identify the least-cost contribution of different sectors and gases for meeting post-2012 EU-25+ (EU25, Romania, Bulgaria and if possible, Croatia and Turkey) quantitative reduction objectives for all greenhouse gases, and to determine a package of cost-effective policies and measures for all sectors and gases towards meeting these goals.The project aims for a comprehensive update of a 2002 exercise undertaken by DG Environment on 'Economic Evaluation of Sectoral Emission Reduction Objectives for Climate Change'. The project will cover (i) techno-economical research on greenhouse gas emission reduction options, and assessment of least-cost policies and measures using the GENESIS database; and (ii) runs of the PRIMES model (an energy system partial equilibrium model) with inclusion of reduction options for non-CO2 greenhouse gases and options that are not (or not fully) included in the PRIMES model, which will identify the least-cost allocation of objectives for different sectors and greenhouse gases.Key deliverables of the project will be:(i) sector reports, with descriptions of sectors and baseline developments, and fact sheet information on emission reduction technologies (including costs, reduction potentials and implementation assumptions); a summary report of the(ii) 'bottom-up' analysis and(iii) the model-based 'top-down' analysis of the least-cost allocation of objectives; and(iv) a summary report, comprising an executive summary of the report, description of the results of the study and a synthesis/recommendation for policy purposes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Developement of CNT doped reinforced aircraft composite parts and a ssociated tooling, using the Liquid Resin Infusion method'.

assistant: **Concept**

BULCANATU project wants to develop feasible techniques for advancedand cost effective composite manufacturing of aviation parts. Thedevelopment of new epoxy resin Carbon Nanotube doping techniquescompatible with Liquid Resin Infusion will open a new era  on fabricationof aerospace parts with improved mechanical properties,  thanks tonanoparticles.  Future aircraft manufactured with doped CNT epoxyresins, would be the increase on electrical conductivity that could lead tothe removal of cooper lightning protection mesh of advanced compositefuselage.The main issues to overcome are the dispersion and stability of the CNTover the epoxy resin, filtration phenomena within the infusion process,and the manufacture of high performance composite parts under “out ofautoclave” conditions at greater viscosities than expected. Thanks to thejoint venture between TR Composites and the Universidad Rey JuanCarlos, all aspects of the call are covered with wide experience toachieve good results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Networked and Cooperating Robots for Urban Hygiene'.

assistant: **Concept**

The DustBot project is aimed at designing, developing and testing a system for improving the management of urban hygiene based on a network of autonomous and cooperating robots, embedded in an Ambient Intelligence infrastructure.The robots will be able to operate in partially unstructured environments (such as squares, streets, parks, etc.) and to vacuumclean them from rubbish and dirt. They will be able to transport small quantities of home garbage, collected on demand from citizens, at their doors. By using preloaded information on the environment (e.g. area maps) and inputs from on-board and external sensory systems, and by taking advantage of the benefits provided by the Ambient Intelligence platform, the robot will be able to move with a proper (and selectable) level of autonomy to carry out its tasks. The robots will be also equipped with multiple sensors for the monitoring of air (e.g. nitrogen oxides ?NOx-; sulphur oxides ?SOx-; ozone -O3-, benzene, COx, etc.), giving in real time information on the environmental quality in real time. Robots will work as mobile stations, which will monitor pollutants levels in highly populated areas (as well as pedestrian, central areas). Acquired data will be also transferred onto dedicated databases by utilizing the features of the ubiquitous communications network. The robots and sensors will be part of an Ambient Intelligence platform, which will integrate not only sensors and tools for monitoring the environment and robot tasks execution, but also communications backhaul systems during clean up/emergency operations, databases technologies, knowledge discovery in databases (KDD) processes for extracting and increasing knowledge on urban hygiene management. Following the computation on stored data, feedback will be sent back
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ultrastable optical frequency comb systems' (ULTRASTABLE) targeting Horizon 2020.

assistant: **Abstract**

The invention of optical frequency combs revolutionized numerous fields in metrology and was honoured by the 2005 Nobel Prize in Physics. Frequency combs have many new emerging applications in optical telecommunications, broadband high-precision spectroscopy and sensing, etc. Monitoring of environmentally relevant gases and pollutants, medical sensing of biomarkers in human breath, or remote sensing of gases relevant for resources exploitation or farming are important areas, in which frequency comb systems might find large applications in the future. However, so far, frequency comb systems are mainly used in basic research, despite their large potential for commercial applications. New technology solutions are required to enlarge the application range of this technology and make it accessible for real-world systems.An important highlight in my ERC StG Mega-XUV project was the first demonstration of a stabilized optical frequency comb from a SESAM-modelocked femtosecond thin disk laser. In this context, we invented a new method for stabilization of optical frequency combs. Our new invention is to use opto-optical modulation of a semiconductor saturable absorber that is placed inside the femtosecond laser cavity. It has several technical advantages compared to the standard method, therefore we submitted a patent application for it. The Written Opinion of the International Searching Authority confirmed its novelty, inventive step and industrial applicability in August 2015. We expect that our IP will enable European industry to continue to be leading this field, because it has several advantages compared to other CEO stabilization technologies, in particular with respect to modulation speed, low nonlinearity and dispersion, and extremely high damage thresholds. With this P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative Rail Intermodal Services' (IRIS).

assistant: **Concept**

The IRIS project addresses task 1 'Integrated demonstration project of innovative intermodal door-to-door freight services on short and medium distances' of the DG VII/DG XIII Joint Call for Proposals under FP4.The overall objective of the project is to demonstrate the feasibility of intermodal transport on short and medium distances and to derive aspects which make this kind of transport a success" which follows the task objective as stated in the Joint Call documentation: "to demonstrate the actual possibilities and limits of making intermodal freight transport more attractive on short and medium distances, and to identify the conditions for making it viable". By means of the three demonstrators, different relevant technical, operational and organisational aspects, which will make this kind of transport an economic success, will be implemented, demonstrated and evaluated.The project and its results will show - on the basis of the three demonstrators - how this truck-dominated field of transport, namely on short and medium distances, can be exploited by intermodal rail transport. In this respect, the project approach contributes to the policy of the CEC to increase the use of intermodal transport in comparison to the modal approach, to achieve sustainability of transport by a more balanced utilisation of capacities and, as a consequence, to increase the efficiency and competitiveness of the European economy. %Three demonstrators, one in the Belgium-German-Dutch hinterland of the seaports Antwerp and Zeebruge, the second in Great Britain in the short and medium distance area of Southampton, and the third in Italy, linking Genoa with the inland terminals in Padova and Bologna will be used as test cases and evaluation pilots, i.e. as backbone for the evaluation of differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'B cell-orchestrated tolerization of T cell-dependent B cell-mediated autoimmune diseases' (2021-2027).

assistant: **Concept**

Failure of thymic tolerance may result in severe autoimmune diseases that target the central nervous system (CNS), including Multiple Sclerosis (MS), Myelin Oligodendrocyte Glycoprotein (MOG)-associated Disease (MOGAD), and Neuromyelitis Optica Spectrum Disorders (NMOSD). Recently, we discovered a new layer of thymic tolerance in that thymic B cells get licensed to present activation-induced autoantigens, among them AQP4 (the target antigen in NMOSD). Thymic B cells are necessary and sufficient to purge the T cell repertoire of AQP4-specific clones.In BREAKING BAD, we will investigate in depth how thymic B cells shape the AQP4-specific T cell repertoire by either deleting AQP4-specific conventional T cells or agonist-selecting Foxp3+ Treg cells. To understand B cell-intrinsic and extrinsic checkpoints of this process, we will use genetic means to disrupt thymic tolerance to AQP4. Since we have cloned a variety of AQP4-specific TCRs, we are now in the position to track fate decisions and functional phenotypes of naïve T cells that react against AQP4, which is – in contrast to MOG – not only expressed in the CNS but also in peripheral organs. Finally, our data indicate that amyloid precursor protein (APP), associated with cerebral amyloid angiopathy and Alzheimer's disease, is an autoantigen that is – very similar to AQP4 – induced in B cells upon CD40 stimulation and expressed in thymic B cells. Therefore, we will investigate the APP-specific T cell repertoire and its ability to provide T cell help for the generation of anti-amyloid Abeta antibodies upon disruption of B cell-mediated tolerance to Abeta peptides by conditional genetic ablation of APP in B cells.In summary, BREAKING BAD will explore the significance of B cell-mediated tolerance for CNS autoantigens. We ant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Screening for monoclonal gammopathy of undetermined significance: A population-based randomized clinical trial' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Monoclonal gammopathy of undetermined significance (MGUS) is a very common precursor condition to multiple myeloma (MM), and related diseases, and can be found in approximately 4-5% of individuals over the age of 50 years. MM is always preceded by MGUS. Current risk stratification schemes, designed to predict those that will progress, are based on retrospective data and rely almost solely on serum protein markers. While they can differentiate high and low-risk patients, they cannot predict outcome for individual patients, are not integrated with one another, and have limited biological correlation. Based on retrospective data, it is recommended that individuals with MGUS are followed indefinitely; however no prospective study has ever been performed to evaluate this or identify optimal monitoring in MGUS individuals. We recently showed that MM patients with a prior knowledge of MGUS had superior survival compared to MM patients without, which raises the question whether routine screening for MGUS in the population might improve survival. To evaluate the impact of screening for MGUS on overall survival, to provide evidence for the optimal MGUS follow-up, and to integrate biological, imaging, and germline genetic markers in evaluating individual risk of progression,  we propose to invite all individuals >50 years in Iceland (N=104,000) to participate in a screening study for MGUS. This will be done by utilizing already present infrastructure for screening in Iceland and the fact that most individuals >50 years have their blood drawn for various reasons during 3 years. We plan to perform electrophoresis and free light chain analyses in these individuals to diagnose MGUS. Individuals with MGUS will be invited to be included in a randomized clinical trial with 3 different ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Gain controls in parallel visual pathways of the mouse'.

assistant: **Innovation**

Research in neurophysiology has identified potentially canonical mechanisms and circuits that are repeated across multiple brain regions. A classic example of a canonical computation is gain control,which in sensory pathways allows neurons to adapt their dynamic range to the statistics of the local environment. Gain control has been most studied in the visual pathway, where it helps make neurons sensitive to both spatial and temporal context. Yet many parallel nerve pathways leave the eye and terminate in different brain nuclei. It is not known whether each of these pathways use different forms of gain control or whether the same mechanisms are used throughout. This project will measure the activity of populations of nerve cells in the two major target nuclei in the brain - the lateral geniculate nucleus, and the superior colliculus - of mice. In anaesthetised mice we will characterise the gain controls that are present in these different nuclei, to understand their similarities and differences. Paired recordings from these two brain areas will be used to establish how gain controls differ in neurons that get input from the same retinal sources. In additional experiments we will make recordings from these areas in awake mice, in the presence and absence of a visual task. In each case we will characterise the gain controls and functional connectivity of neurons to establish how gain controls modulate the flow of information during visual processing. Our work will therefore provide knowledge of whether gain control forms a single canonical mechanism, or if it is used flexibly to support specific computational requirements.