RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Directed co-evolution via engineered cell-to-cell communication'.

assistant: **Innovation**

The aim of this Marie Skłodowska-Curie Fellowship (Evolving Together) is to develop an innovative new system for directed co-evolution of ligand-receptor pairs in two different cell populations. This novel cell-to-cell directed evolution platform will facilitate the development of synthetic, orthogonal intercellular signaling pathways that can be applied to control and manipulate cells by user-defined expression of a target gene. The selection of the reporter gene can be extremely flexible, which allows full customization of the downstream cellular response, such as programming self-organized cellular patterns or targeting specific cell populations. This Fellowship will be undertaken under the supervision of Prof. Tom Ellis (Imperial College London Centre for Synthetic Biology), who is internationally renowned in synthetic biology and is leading the UK’s effort in the Synthetic Yeast Genome Project (Sc2.0), one of the world’s largest synthetic biology projects to date. My proposed research brings together many aspects of synthetic biology and molecular biology techniques, including molecular cloning, cell culture, protein and genome engineering, directed evolution, and next generation sequencing (NGS). In addition, we will extensively use fluorescence-activated cell sorting (FACS) and confocal imaging to isolate and characterize the populations of interest. These techniques combine skills I’ve acquired during previous research along with the expertise and methods of Tom Ellis’ group. Evolving Together presents an opportunity to make a major new innovation in directed evolution that can impact various fields of biology and biomedicine such as signaling, protein engineering, biomaterials, synthetic biology and therapeutics.


**Keywords:** Protein engineering, directed ev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Heavy Payload Helicoper for Last Mile Rescue' in the context of a Seventh Framework call.

assistant: **Objectives**

The proposal addresses the possibility for Civil Security operators to use large air transport systems for deploying heavy loads on crisis sites (last mile). It investigates in particular the deployment in civil missions of systems which are now targeted only for military use. A broad range of European Civil Security users will be involved in developing appropriate requirements for offering transport solutions to the management of large emergencies as often encountered in Europe. Air transport solutions potentially able to meet the requirements will be examined, together with operational issues related to vehicle certification, operation regulation and dual-use, with the aim to develop functional specifications that will be fed into identified vehicle development and/of product investment programmes. The European Future Transport Helicopter (FTH) programme will be specifically considered. Potential solutions with large airships and transport UAS will also be examined. Business models taking into account pooling and sharing options will be proposed; feasibility, economic aspects and potential benefits will be assessed. Support to the Civil Security policies will be prepared with dissemination activities and the development of roadmaps towards effective implementation of the analysed solutions and towards a common European approach for the definition of large air transport systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular Machines Functioning in Cells' in the context of a Horizon 2020 call.

assistant: **Objectives**

The main motivation of BIOMOLMACS training network is to establish a multidisciplinary training network on the emerging topic of molecular machines and to train the next generation of highly-skilled researchers in this exciting field. In the last decade, great efforts have been spent on the development of synthetic strategies for the creation of molecular machines, and these efforts have been acknowledged by the Nobel committee in 2016. In parallel, synthetic and polymer chemistry fields have made significant advances in the last decade, to the point that we are able to design and control the sequence of individual repeat units along synthetic macromolecules. Sequence controlled polymers open up greater possibilities in the precise formation of nanoparticles such as polymersomes, and even support the new generation of artificial cells. The synthetic combination of molecular machines and precisely designed synthetic macromolecules will open new avenues for innovative nanobiomedical applications. Early Stage Researchers of BIOMOLMACS will be trained on the design, chemical synthesis, and biophysical characterization of such complex macromolecular architectures as well as their incorporation in artificial and living cells. Finally, biophysical understanding of the molecular interactions in living/synthetic systems will be able to bridge the gap between fundamental and applied research in this exciting field.


**Keywords:** Glycopolymers, biomaterials, polymersomes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'comBinig cELLular and humoral immunE RespOnses as a vaccine strategy against staPHhylOcoccus aureus pathogeN' (BELLEROPHON) under Seventh Framework.

assistant: **Objectives**

Staphylococcus aureus, including Meticillin-resistant S. aureus (MRSA), is one of the most important bacterial pathogens, causing skin, wound, and deep infections in both the community and in hospitals.Treatment is difficult and expensive and may require prolonged intravenous antibiotic therapy. Since there is no licensed vaccine by FDA or EMEA, prevention also relies heavily on antimicrobials to which antibiotic resistance is developing.To reduce S. aureus disease burden, and antibiotic use associated with it, BELLEROPHON will design, manufacture, and assess in a Phase I clinical study a novel S. aureus vaccine candidate targeting both the cellular and humoral responses. It is designed to be protective against both MRSA and more sensitive S. aureus strains.The project will rely on 4 key components:i) a recently discovered and highly conserved T-cell inducing antigen individually capable of eliciting substantial protection in mouse models;(ii) a secreted toxin antigen, antibodies against which reduce mortality (Hla);(iii) an innovative, proprietary and potent pro-immunogenic series of tags (IMX313 series) which can be fused to the antigens;(iv) the use of viral vectors, including an innovative and proprietary adenoviral vector (ChAdOx1) and/or new ways to use viral vectors to generate protective immunity (MVA mixed with proteins).We willi) identify the most protective method of combining these components in a manufacturable and clinically deployable manner;ii) manufacture and perform initial human studies of the vaccine;iii) identify additional antigens which might further increase the efficacy of the initial product.Our approach will contribute clinical safety and immunogenicity data for a novel vaccine strategy targeting one of the key bacterial pathogens in man. It w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Viral Imaginary: Between Crisis and Routine' to be submitted under Horizon Europe.

assistant: **Abstract**

This action interrogates the social and cultural interpretations and narratives of viruses in Asia. It focuses specifically on how viruses have been historically narrated, interrogating the framings of viruses as routine versus viruses as crisis. To examine these framings, this action will interrogate the historical layering mobilized in Asian popular culture. By analyzing these reflections of viruses alongside how people respond to them, the action will query how historical parallels are used to narrativize the virus, making “the virus” a knowable entity. The overall goal of this action is to elicit the lessons learned from these social and cultural interpretations that can be compared to Europe and the world.


**Keywords:** Viruses, Popular Culture, Asia, South Korea, Hong Kong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Resilient Bio-inspired Modular Robotic Miners' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

ROBOMINERS will develop a bio-inspired, modular and reconfigurable robot-miner for small and difficult to access deposits. The aim is to create a prototype robot that is capable of mining underground, underwater or above water, and can be delivered in modules to the deposit via a large diameter borehole.  In the envisioned ROBOMINERS technology line, mining will take place underground, underwater in a flooded environment. A large diameter borehole is drilled from the surface to the mineral deposit. A modular mining machine is delivered in modules via the borehole. This will then self-assemble and begin its operation. Powered by a water hydraulic drivetrain and artificial muscles, the robot will have high power density and environmentally safe operation. Situational awareness and sensing is provided by novel body sensors, including artificial whiskers that will merge data in realtime with production sensors, optimising the rate of production and selection between different production methods. The produced high-grade mineral slurry is pumped to the surface, where it will be processed. The waste slurry could then be returned to the mine where it will backfill mined-out areas. ROBOMINERS will deliver proof of concept (TRL-4) of the feasibility of this technology line that can enable the EU have access to mineral raw materials from otherwise inaccessible or uneconomic domestic sources. This proof of concept will be delivered in the format of a new amphibious robot Miner Prototype that will be designed and constructed as a result of merging technologies from advanced robotics, mechatronics and mining engineering. Laboratory experiments will confirm the Miner’s key functions, such as modularity, configurability, selective mining ability and resilience under a range of operatin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '3D Biofabricated high-perfoRmance dna-carbon nanotube dIgital electroniCKS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Silicon-based CMOS technology is approaching its performance limits, but the demand for more powerful computers — driven by rapid advances in applications such as the Internet of Things, big data and artificial intelligence (AI) — remains. The discovery of various nanomaterials provides new opportunities to further develop information processing technology. Carbon nanotubes (CNTs) have, in particular, demonstrated excellent properties as a channel material in transistors. Computers based on CNT field-effect transistors (FETs) have been theoretically predicted to provide a power-performance improvement of ten times over computers based on Si-CMOS technology. However, the fabrication of high-performance CNT-nanoelectronics, and the realization of the full potential of CNTs, is highly challenging. A technological revolution would be a reliable approach to fabricate a new family of CNT-based devices that could enable aligned arrangement of the nanotubes avoiding the critical steps related to nanolithography. In particular, biofabrication using DNA-templated CNT arrays FETs has been demonstrated to further scale the alignment of CNTs within the FETs well beyond standard lithographic feasibility. 3D-BRICKS will raise this concept of integrated self-assembly CNT-nanocircuits to a completely new level by moving towards the third dimension. Indeed, the versatility of DNA nanotechnology will be the root for conceiving 3-dimensional (3D) CNT-FETs and CNT-nonvolatile memories. DNA nanotechnology will also enable to complement the CNT deposition with metallic connections, hence realizing a working circuit. This will reduce the foot-print of the final device while enhancing its efficiency, hence providing a breakthrough solution to realize the next-generation nanoelectronics. Further
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Wearable Applications enabled by electronic  Systems on Paper'.

assistant: **Objectives**

The WASP project aims at bringing the much-needed step change in flexible and wearable electronics by developing a new industrially driven enabling printing technology for the definition of electronic devices and circuits on paper, a flexible and foldable substrate, which is low cost, disposable, biodegradable, easily obtainable in nature and compatible with high speed roll-to-roll processes. The proposed technology is based on an environmentally friendly process and addresses the needs for future circular economy, as well as that for cheap, flexible and lightweight, multi-functional electronics. At the end of the project, a demonstrator will be released, able to sense biometric parameters (i.e., humidity, pH, glucose levels) and to communicate to an external reader, developed on purpose within the WASP activity.


**Keywords:** Printable and flexible electronics, two-dimensional materials, RFID, biosensors, solar cells, health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular and electrophysiological studies of calcium channel - g protein interactions' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

In neurons, voltage-dependent calcium channels (VDCCs) are involved in the release of neurotransmitters, and in a number other processes in which a rise in intracellular calcium is the primary signal.The function of VDCCs may be modulated by several means including phosphorylation and activation of pertussis toxin-sensitive G proteins by a variety of receptors. Professor Dolphin's group have shown by the microinjection of antisense oligonucleotides in dorsal root ganglion neurons that G protein-alpha(o) subunit is the primary protein involved in coupling GABAB receptors to inhibition of VDCCs, and that the VDCC accessory betha subunit play a pivotal role in the coupling process.The overall results suggest a competition mechanism of activated G protein subunits and VDCC-betha subunits for binding to VDCC-alpha subunits. In the present project we are intended to identify the molecular determinants for such interactions in the subunits of different subtypes of cloned VDCCs and in the G-protein subunits. This will be examined biochemically with the gel overlay technique and using binding assays involving the measurement of protein-protein interaction by binding to scintillant containing beads. Whether the selected sequences disrupt productive G protein coupling to calcium channels will subsequently be studied in an electrophysiological setting, using the patch clamp technique in neurons and neuronal cell lines as heterologous mammaliar expression systems. Training content (objective, benefit and expected impact) It is now essential for electrophysiologists working on ion channel biophysics, to have a good grounding not only in the principles of molecular biology and manipulation of DNA, but also in the techniques involved in studying protein-protein interactions. The reason
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ultra fast single photon counting imaging', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The objective of the project is to realize and qualify an image acquisition interface with sensitivity to single photons, large input window (~ 200 mm), ultra fast gate time (~ 10 ns), high resolution (~ 100,000 pixels), high speed of pixels readout (~ 40 Mpixels/s) and on-line image pre-processing (background subtraction, normalisation, non destructive compression, etc.). The achievement of these project goals requires system's components that are not offered by european suppliers, or needs improved performance respect to the presently available ones also from extra european suppliers. In particular the more adaptable configuration for a scientific image acquisition system, is composed by an input intensifier and demagnifier coupled by optical fibers to a vacuum image pipeline for the time selection (delay and time window) of the image according to an external trigger. The output of this optoelectronic device gives high resolution image to an intensified CCD camera equipped with the appropriate on-line preprocessing electronic interface that transfers the image to a computer.All the components of this chain can be substantially improved, with an RTD efforts that combines the experience of advanced academic research laboratories and the skill of european manufacturers. These advanced components, once available on the european market, can find applications in several fields where the extraction of quantitative information from various type of images, is the basic laboratory technique, in medical diagnostic and industrial applications related to night vision, surveillance, defence and flight assistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Temporally complex odour information encoding'.

assistant: **Concept**

A fundamental challenge for the brain is to extract relevant information from an ever changing external world. Natural odours are in a constant state of flux. Turbulent airflow shapes odours into spatiotemporally complex plumes that carry information about the olfactory scenery and provide vital clues about the location of, for example, food sources or predators. How the mammalian olfactory system extracts information about space from temporal odour dynamics, however, is still not well understood.Recent methodological advances in presenting dynamic odour stimuli, neural activity recordings and machine-vision algorithms now offer the exciting opportunity to address this fundamental question. Using a multidisciplinary approach, this project will uncover how temporally complex odour information is processed across the olfactory system and how odour dynamics give rise to behaviour.We will first investigate how temporally complex odour information is represented across key structures of the mammalian olfactory system using in vivo physiology. This will provide important groundwork for the next step, elucidating the cellular and circuit mechanisms underlying the encoding of dynamic odours in the early olfactory system. Finally, we will study which features of temporally complex odours are used for navigation behaviour by simultaneously recording and correlating the animal’s respiration sampling strategy, the dynamic odour profile encountered by the animal and neural activity from early and higher order olfactory areas in freely moving mice.By combining cellular and systems neuroscience with behavioural investigations, we aim to directly assess how mammals use olfaction to extract information about space from time. I strongly believe that this innovative research programme wil