RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Patent-pending co-fermentation technology that mimics nature to create natural, delicious and nutritious vegan seafood products.' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Koralo creates natural, delicious, and nutritious vegan seafood through a patent-pending co-fermentation technology that mimics nature.Starting with a beach walk in the spring of 2021 Koralo was born out of the idea to create a sustainable food source inspired by algae washing up on shore.  Sina Albanese, a serial sustainability entrepreneur with the desire to protect our oceanic ecosystems is supported by her father Dr. Guido Albanese with over 25 years of working experience in the food industry in this trans-generational start-up. Koralo mimics with deep-tech the best example we know: Nature. In nature, microalgae are consumed by small fish that are then consumed by larger fish which end up on our plates. At Koralo, we have replaced fish with a unique co-fermentation developed in Germany, where mycelia of edible mushrooms feed on microalgae to create a natural fish alternative product.We have already filed two patent families on this technology and have received positive assessment reports on both our European as well as Global patent applications. We have tested our products with chefs and consumers both in Europe and Asia and are expanding our range to salmon and shellfish such as shrimps and scallops. Koralo is partnering with the largest microalgae producer in Europe in Portugal for scaling up of Koralo's technology with their expertise in microalgae and fermentation and we have successfully reached TRL 5 - 6 on existing equipment. To launch our European production with them we have closed an MoU. Koralo will launch its whole-cut vegan fish in Q1 of 2023 in B2B channels in Korea with further expansion to Singapore, Hong Kong, Europe and the US within the next 5 years. For this end we have closed several MoUs with restaurants and distributors in Korea already. Our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Surface Plasmon Nanodevices : Towards sub-wavelength miniaturization of optical interconnects and photonic components' (PLASMO-NANO-DEVICES).

assistant: **Concept**

Miniaturizing optical connections and controlling optical processes at the sub wavelength scale are expected key technologies not only for the future of data processing but also for the development of various sensors needed in nanotechnologies. Among other strategies, a promising perspective shows up from the research works on optical nanodevices involving surface plasmon polaritons sustained by nanostructures, also called plasmonics.During the last years, European laboratories succeeded to build a significant advance over concurrent groups of other continents. To ensure the definitive European leadership in this field of research with a high potential of industrial applications, it is now essential to federate the human and technical resources spread in Europe into a Network of Excellence aimed at developing prototypes of surface plasmon nanodevices for controlling optical processes at the sub wavelength scale.In the framework of well identified scientific and technical objectives, the participating organizations propose as aim of the present network of excellence to test an alternative structure of the management, evaluation and decision making mechanisms of research projects in order to improve the incisive and target oriented character of the research program.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification and mutational analysis of the nucleobase and nucleoside transporters of Aspergillus nidulans implicated in the transport of antiviral/anticancer drugs' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Nucleobases and nucleosides play a key role in nucleic acid and nucleotide metabolism in all cells, act as signalling molecules, neuromodulators and serve as nitrogen source in plants and many micro-organisms. They are synthesised de novo or, when de novo synthesis pathways are lacking, salvaged from the environment (purine auxotroph parasites; specialised mammalian cell types). Transport of nucleobases and nucleosides across biological membranes is mediated by specific transport proteins. Nucleobase- and nucleoside transporters have been identified and characterised in a variety of pro- and eukaryotes. However, due to the limited amount of molecular data, it remained unknown how the secondary structure determines the substrate-specificity of the transporters.Many antiviral and anticancer nucleoside drugs are substrates of nucleoside and some of the nucleobase transporters, such as 5-fluoro uracil, 5-fluoro uridine and their derivatives. Since the transport of nucleoside drugs is critical to their therapeutic effectiveness, understanding the molecular mechanism of the transport process could enable the design of more effective nucleoside drugs and those with better absorption profile. Currently, the rational design of these drugs is hindered by the absence of high-resolution structural data on the transporters. Revealing the structure-activity relationships of transporters could facilitate the discovery of novel drugs with affinity specific for particular transporters.This project intends to investigate the uracil and uridine substrate specific nucleobase and nucleoside transporters of the model organism, A. nidulans, and subject them to mutational analysis using a complex molecular biological strategy to generate and characterise various functional mutant derivatives o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Cancer tailored next generation cellular therapies'.

assistant: **Objectives**

Cellular therapies are commonly used to treat hematological cancers but have yet to be established in solid oncology. Their evolution has been fuelled by hypotheses derived from cell biological observations in cancer models. Most approaches, however, will either never enter clinical development or fail clinical testing, often due to inadequate models of disease and their lack of relevance to human biology.In CATACLIS, I propose the first unbiased development of cellular products based on patient characteristics in order to address this enormous translational gap and ultimately provide more effective cell therapies to patients with solid cancers. CATACLIS will herald a paradigm shift in cell therapy by reversing conventional model-to-patient innovation (""forward translation"") to patient-generated ideas tested in patient-derived models into clinical trials (""reverse translation"").I have discovered novel approaches to improve T cell function, which resulted in a clinical trial and established me as a leader in the field of cellular therapies. The challenge I will now face is to move beyond model bias and integrate cancer heterogeneity across patients and entities. In CATACLIS, I will use single cell data sets from patients to inform the design of next generation cellular therapies capable of overcoming current limitations in solid cancers, namely 1) access to tumor tissue, 2) target antigen(s) selection, and 3) immune suppression. To maximize clinical relevance, CATACLIS will use patient-derived materials from hypothesis generation to in vivo testing. This will enable me to create cellular products tailored to the patient´s cancerMy research will not only result in novel cellular products for further testing and development toward clinical trials, but it will also serv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Telemonitoring and Telemedicine for Hospitals Assisted by ICT for Life saving co-morbid patients in Europe As part of a Patient personalised care program of the EU', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

A growing body of evidence suggests outcome improvement in Intensive Care Unit (ICU) patients by means of telemedicine. At present a highly interoperable, manufacturer-independent telemedicine-platform for detection of ICU-patients at increased risk is missing.  Encouraging results in other eHealth-projects influenced the decision to use pre-commercial procurement (PCP), in order to provide best possible solution for THALEA.<br/>Clearly identified demand and strategy detected by international ICU experts, consented by multidisciplinary stakeholders (IT-experts, excellence cluster eHealth, insurance companies and ministries) during pre-consortium meeting ensures a perfect match of demand, strategy and funding instrument in an early phase of the project. Besides inacceptable high mortality in ICU patients, telemedicine has the ability to mitigate problematic pan-European challenges, like demographic changes, shortage of ICU professionals, and scarcity of financial resources.<br/>Bringing market participant and stakeholders (procurers, ICU-specialist, IT-specialist) in close collaboration, PCP within THALEA will create an appropriate common solution fulfilling demands of a telemedical research framework. Focus on interoperability and scalability will lay foundations for future follow-up projects in telemedicine. Compliance with Directive 95/46/EC is granted by limiting access to sensitive data to health professionals with obligation of professional secrecy and data transfer bound to provision of care in a tele-ICU service.<br/>THALEA will help to close a knowledge-gap in Europe as well as to close up to research superiority projects in the US. By PCP, dissemination of this promising technology will be spread in Europe thus helping doctors to save more lives and as a result
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Flow on thin fluid sheets', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Physical phenomena that combine effects on a surface and that in the bulk occur in many fields, ranging from crystal growth in chemistry and proton diffusion in biomembranes, through tyre aquaplaning and self-cleaning materials. We consider this multi-scale problem specifically for coupled bulk-surface fluid flow. Simulating these problems with traditional fluid solvers is challenging because of the different scale of the surface phenomena versus that in the bulk. Towards this end, specialized thin film flow models have been developed to accurately capture surface-level flow effects. However, it remains impossible to automatically detect the formation of thin fluid sheets and resolve the bulk/sheet coupled flow. This limits the application of thin film models. Advances made in thin film modelling have not been applied to complex flow situations where, for example, a free flowing bulk fluid can form thin films over an obstacle, or where sufficient fluid collects on a moving thin fluid sheet to obtain bulk flow. Such problems rely on bulk flow simulations with significantly finer resolutions to capture the surface-level effects, which dramatically increases computation time making full dynamic simulations unrealistic for actual applications.The primary objective of this project is to model bulk/surface flow phenomena numerically. We will propose novel mathematical models to computationally simulate flow of thin fluid sheets on moving curved surfaces, which can predict not just the evolution of an existing film, but also their formation, collapse and break up. We will develop efficient methods to two-way couple film flow with bulk fluid flow which are able to identify regions where surface level effects are relevant, on the fly. This fellowship will build on the expertise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cost-efficient and safe cellulosic food pad' (CellSorb), addressing dissemination and exploitation.

assistant: **Impact**

Synthetic superabsorbent polymers (SAPs) are the mainstream option (i.e. 90% of market share) to be used as absorbent pads in a number of applications, from sanitary products (e.g. diapers, tampons) to food pads (e.g. meat/fish trays to soak up exuded liquids and keep the food fresh). This is mainly due to their superior price-efficiency balance. Nevertheless, proven toxicity and carcinogenic effects related with their use have raised growing health concerns. To put these dangerous practices aside the need of economical biodegradable and non-toxic pads to compete with the synthetic ones are on the rise.Cellsorb introduces a totally safe (i.e. non-toxic) closed food pad made from bioplastics and superabsorbent micro-cellulose material with the following superior features: 1) Absorbs multiple times its own weight similar with the performance of synthetic food pads, 2) It is fully compostable and 100% renewable, and 3) Competitive pricing over synthetic made food pads. Its uniqueness lies on our innovative production method able to produce microcellulose materials from pulp, creating a non-toxic and biodegradable superabsorbent able to compete in cost-effectiveness with current synthetic ones.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dynamical zeta functions, noncommutative geometry and arithmetic zeta functions', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The general theme in which I am interested are more or less hypothetical connections between (perhaps very generalized) dynamical systems and associated zeta functions on the one side and arithmetic zeta functions on the other side. Also the formalisms of my thesis were developed simultaneously for both kinds of zeta functions. First I want to improve some parts of my thesis in the more special situation of dynamical zeta functions. After that (which is a cut) I will try to improve results of Bost and Connes about C*-dynamical systems connected with arithmetic zeta functions. If there is time enough I also want to deal with a class of non-classical dynamical zeta functions introduced by Deninger and/or a new class of 'arithmetic' dynamical systems which I want to develop. Training content (objective, benefit and expected impact) As I was more occupied with arithmetic zeta functions during my time at Deninger's research group, I now want to study the side of dynamical systems more intensely. For this I want to learn the basic theory of classical dynamical systems and zeta functions (Ruelle zeta functions) as well as the fundamentals of noncommutative geometry for which the experts are at the IHES. I plan to emphasize this analytic side also in my future research. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Intracellular Carrier Against Resistant microOrganisms (ICARO)'.

assistant: **Concept**

Intracellular pathogens and viruses elicit immune responses by presenting their antigens to T cells. At the same time, they have evolved immune evasion mechanisms which essentially reduce the antigenic repertoire that is presented to the immune system. To overcome this problem, the EIC-funded ICARO project proposes to use silicon-based microchips that carry pathogen antigens and can be internalised by immune cells to aid antigen presentation. These biochips are retained within cells for a long time and will provide the foundation for a novel vaccination strategy that can boost specific and long-lasting T cell responses. The consortium aims to develop standardized methods for ICARO manufacturing and functionalisation to be easily applicable to different pathogens, thus accelerating the generation of new vaccines in the future


**Keywords:** MEMS, vaccines, CD8, intracellular pathogens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Allosteric effects induced in 14-3-3 targets' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

14-3-3 proteins, found in all eukaryotic cells, are known to be important in cell-cycle regulation, apoptosis, and regulation of gene expression. They are also associated with oncogenic and neurodegenerative amyloid diseases. 14-3-3 proteins are active as homo- or heterodimers and bind more than 300 diverse target phosphoproteins, thereby forcing conformational changes or/and stabilizing active conformations in their target proteins. To date, no crystal structure is known for a 14-3-3 dimer in complex with a doubly phosphorylated target protein; this prevents a full understanding of the 14-3-3 molecular mechanism. I propose a computational approach to model the function of 14-3-3s on three of its target ligands: serotonin N-acetyltransferase (AANAT), tyrosine hydroxylase, and tryptophan hydroxylase. This approach will combine restrained molecular dynamics simulation for phosphorylated residues with the novel Hamiltonian replica exchange using soft-core interactions developed by myself and Dr. Oostenbrink. The obtained structure for 14-3-3/AANAT will be compared with the available crystal structure of AANAT in its active form. Computationally predicted structures of doubly phosphorylated tyrosine hydroxylase or doubly phophorylated tryptophan hydroxylase in complex with a 14-3-3 dimer will be verified by comparison with several fingerprint-type NMR spectra measured for each complex during the proposed project. The proposed approach will have general applicability to most doubly phosphorylated 14-3-3 protein ligands. The research proposed here will not only deepen our understanding of 14-3-3 function, but will also enhance our knowledge of essential basic mechanisms with respect to key regulatory proteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CIMPLE FAST TRACK MODELLING SUPPORT CENTER NETWORK' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This project aimed to improve the exploitation of the CIM tools developed in ESPRIT, VALUE, and SPRINT projects by preparing training material for intermediary industrial centres and end-users to help SMEs, with CIM process implementation. The training/consultancy centres were industrial related research centres already working with this target group. The partners were drawn from a range of EU countries and included multi-media companies, intermediary bodies, training organisations, consultancy and IT firms. The main output was a structured approach for SMEs to analyse their processes, goals, IT requirements that is codified in a CD Rom. A range of training materials is also available. Initial feedback from intermediaries and SMEs has been good. However, the need for localisation and for constant up dating of the material may inhibit its usefulness.The involvement of several European partners with complementary roles and functions enabled the horizontal transfer among European regions and a vertical one among the different types of partners involved with end-users (SME). The success of the exploitation lies in the large number of SME existing in Europe that need urgently to modernise the management system if they want to survive and be competitive. The market tests already accomplished in the ESPRIT project show that there is a need for this type of product if the SMEs are able to implement.