RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Alpine Safety, Security And Information Services and Technologies' (ASSIST) under Sixth Framework.

assistant: **Objectives**

ASSIST aims at improving the capabilities of risk warning and risk management in the Alpine region by implementing an integrated pre-operational service based on existing precursor services and related infrastructure. Some 30% of the EU territory consist of 30 million inhabitants encompassing numerous mountain ranges or chains, including the Alps, Sierra Nevada, Island of Crete, Pyrenees, Apennines, Sierra da Estrela, Massif Central, upper Tatra, Carpathians, etc. Mountain areas represent over 50% of the territory in Italy, Spain, Greece, Austria, Switzerland and Portugal. ASSIST deals with the characteristics of these mountain areas. The goal is to implement pre-operational services and realise advanced integrated safety and information services for the Alps. The advanced services shall be based on already operational crisis and information and crisis communication systems.The overall objective of the proposed project is to specify, design, implement and validate a generic solution for the production and exchange of data products used for risk prevention and risk event management. The project will focus on risks typical to mountainous areas e.g. avalanches, landslides, debris flows, floods, etc. The backbone of the overall concept are so-called Service Nodes. These nodes are autonomously operated by organisations responsible for risk management. The Service Nodes are capable to request and ingest raw input data (e.g. EO data), process the input data into products suitable for risk prevention/crisis management, distribute the products within the User Network (fixed/mobile regional risk management centres and - if required - to the mobile staff), exchange products with other Service Nodes operated by different organisations (e.g. police, hospitals, air rescue, fire fight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Establishment of a cell line and dna bank for genetic risk assessment and post transplant monitoring of complications following stem cell transplantation' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Allergenic stem cell transplantation (SCT) remains the ultimate treatment for patients with lymphoproliferative and haematological disorders. Genetic differences, including transplantation antigens and cytokine gene polymorphisms, between patient and donor constitute genetic risk in SCT. Success of SCT relies on an accurate assessment of genetic risk factors in order to improve outcome. Genetic risk factors will be assessed by the use of an immortalised cell and DNA bank where outcome of the transplant is known. We aim to pool resources and establish a biological collection of fully genotypic ally characterised patient and donor immortalised cells for both in vitro patient monitoring post transplant and as a constant supply of DNA for genetic risk assessment; thus creating a unique and important European collection for use within the transplant community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High Energy Digital Radiography' under Seventh Framework.

assistant: **Concept**

The project objective is to develop digital computed radiography technology for the volumetric examination of large scale safety critical pressure components (e.g. pump bowls, valve bodies, thick section vessel and pipe welds) for the detection of in-service defects, the presence of which could lead in catastrophic component failure. Energy sector businesses (e.g. oil & gas, petrochemical and power generation - civil nuclear and fossil fuel) use processes that operate at high pressure and often high temperature. The engineering components used in such processes include for example, pipes, valves, turbine casings, pump bowls, catalytic crackers/reformers etc, all of which can be made of large section thick materials to withstand the severe pressure/temperature conditions under which they operate. All of these components can be prone to in-service failure resulting from material degradation mechanisms such as metal fatigue, creep and corrosion. Failure of such components could easily be catastrophic in terms of local and district fatalities/injuries and environmental /economic impact. There are approximately 700 refineries, 5000+ chemical plants, 450 nuclear power stations and in excess of 3000 fossil fuelled power stations around the world. The trend is for the number of these plants to increase as the worlds developing countries will consumes ever increasing amounts of energy. Capital assets such as power stations, refineries and petrochemical plants usually generate revenues of typically €1 million/day. However, despite their strategic and critical applications and the dire ‘consequences of component failure’ (local and district safety hazard, environmental and economic), there are generally no economic, reliable Non-Destructive Testing (NDT) techniques to volumetrical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hard photon processing (HARP)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Microoptical systems increase their impact on our daily lives, e.g. in tele-communication, medical sensoring and in projection systems. This project aims to exploit the shortest wavelength of high power lasers (VUV 157nm F2 laser) to improve the resolution and quality of several microfabrication processes. The high (hard) photon energy will allow Bragg gratings in fibers and planar wave guides as well as direct removal processes with increased material flexibility, higher processing speed, finer pitches and better reproducibility compared to longer wavelengths. As investigations are focused on brittle materials like glass and silicon there will be an obvious exploitation effect by end-users coming from telecommunication and electronics industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Diversity of bacteriophages in the ancient human microbiome' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

While recent work has begun to shed light on the microbiota, which includes the trillions of bacteria and phages that inhabit our body, our understanding of its evolution over the course of human history is limited. To answer research questions regarding the development of the human microbiota over time, researchers have begun to sequence ancient DNA from well-preserved fecal and dental samples to understand their bacterial community composition. However, an important group of the microbiota, bacterial viruses (or bacteriophages), which play a large role in influencing bacterial community structure and can affect human health and disease, are often understudied in these ancient samples. Here, we propose ARCHAIC (bActeRiophage in the anCient HumAn mICrobiome), a project which aims to answer key questions regarding these important viral populations in these ancient samples. Using an integrative and collaborative approach, we will use sequencing data of ancient paleofeces and dental calculus to study the oral and gut microbiome from a variety of time periods. This novel work will allow us to develop a pipeline to identify viruses in ancient samples and answer the question - do ancient bacteriophage populations resemble modern ones? In addition, by identifying phages in these ancient samples, we will be able to probe the sequencing data for insights on phage evolution, the development of bacterial defense systems against phages, as well as reconstruct ancient phage genomes to identify novel phage/host pairs. ARCHAIC will move the field of phage biology forward by identifying phages in these relatively understudied ancient samples and will have results that will be applicable to the fields of bacterial evolution, anthropology, and bioinformatics.


**Keywords:** metagenomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biosynthesis of cantharidin/palasonin in plants and insects' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content We propose to study the biosynthesis of cantharidin, an insect sesquiterpene in parallel with palasonin a plant sesquiterpene with only one methyl substituent difference. Regarding biological activity, cantharidin has very strong Phosphatase A2 inhibitor activity and act similarly to okadaic acid and respectively, palasonin is an antihelmintic compound of Indian folk medicine. The mode of action of cantharidin in animals is also of great importance for cell biology, since the compound affects protein like Phospholipase A2. The recent work of collaborators shows that insects are able to maintain a certain level of the ' bound' toxin by reversible conjugation (probably as a imide bond). We have also good evidence that catharidin can also be found in plant systems like Neem or 'Gvtterbaum' trees. None of the individual steps of transformation from sesquiterpene farnesol are known. On another hand, we can be performed our studies on this biosynthesis in Butea frondosa plant cell culture. We have already established this plant cell culture, and we have observed the biosynthesis of (+)-palasonin in the suspension culture after stimulation with elicitor (jasmonic acid). Later, the use of plant cell culture of Neem tree, may also facilitate the search for the intermediates between farnesol and cantharidin and the 'bound' cantharidin itself. Training content (objective, benefit and expected impact) The project will include synthesis of the deuterated farnesol analogues and also palasonin and cantharidin itself realized by Diels-Alder reaction and previously described. It would be also a part of the project involving spectrometry methods for structure elucidation of the bound cantharidin. The scientific benefits of these studies would be of two lev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Implementation of cost-optimized childhood vision and hearing screening programmes in middle-income countries in Europe'.

assistant: **Concept**

Screening for vision and hearing disorders in children has shown to be highly effective. EU-directive 16620/11 invites EU-member states to give priority to such screening programmes. Early detection and treatment of a lazy eye (prevalence 3%) prevents lifelong visual impairment. Early detection and treatment of hearing impairment (prevalence 0.15%) prevents delayed speech and language development.Across Europe inequity exists in the provision of childhood vision and hearing screening programmes (VAHSPs). High-Income Countries (HICs) have VAHSPs, but they vary with regard to age and frequency of testing, tests used, uptake, screening professionals, referral pathway and funding. This makes it difficult for healthcare providers and policy makers to decide what VAHSP to implement in Low- to Middle-Income Countries (LMICs) and how.In this study, cost-optimised, evidence-based VAHSPs will be implemented in two LMICs, based on collated evidence from existing VAHSPs in Europe. Data on VAHSPs, demography, administration, general screening, screening professions, uptake and treatment availability will be gathered in an established network of professionals in 41 European countries and used in a disease/health system modelling framework to predict benefits and cost in the most optimal health system, taking regional diversity and organisational and resource requirements into account.Model-developed VAHSPs will be tested in the county of Cluj in Romania for vision, and in three counties in Albania for hearing screening. A generic strategy for implementation will be developed by detailed tracking, and from identified requirements, facilitators and barriers. The decision-analytic modelling framework and the strategy for implementation will be packed into a transferable TOOLKIT that wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Micro machining with abrasive waterjets', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Miniaturisation of products requires non-contact machining of micro components. Lasers, wire discharge machining (EDM) and abrasive waterjets are the three main non-contact machining methods but abrasive waterjets have yet to be commercialised for micro machining. This project will result in micro abrasive waterjets becoming an established method for micromachining components from ceramics, metals, glasses, composites and layered materials.  Finepart Sweden AB has been assigned patented and patent applied technologies by a UK based pioneer of micro abrasive waterjets in exchange for shares. A prototype micro abrasive waterjet system, with cutting jet diameters down to 80 µm, has been used to cut a wide range of materials and material thicknesses. Technical developments will be scalable to smaller cutting jet diameters and for exploitation in fine and macro machining.Finepart manufactures and sales a fine abrasive waterjet machining centre whose platform is constructed to advanced machine tool standards with accuracies needed for micromachining. The machining platform will be adapted for micromachining including 5 axis capabilities.It is estimated that the development of micro cutting capabilities will increase the market for abrasive waterjet based machine tools by 20%. The market in 2014 is estimated at EUR 0.7 billion with predictions it will grow to over five times its current size.Finepart’s strategic objective is to develop an international business based on micro abrasive waterjet machining centers. Selling will be through a global network of machine tool distributors with an extensive European distributor network in place when sales of micro abrasive waterjet center commence. A business plan will set out the technical developments needed and costs to demonstrate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Automotive glazing' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Automotive glazing plays a critical role in the development of the 2000 years car. Following the strategic guidelines of the EUCAR Master Plan, clearly automotive glazing has to fulfil new performances that will directly impact on:  safety: visibility, passenger protection, car handling and thermal, acoustic driving comfort;  environmental sustainability, recyclability and fuel consumption (weight reduction and aerodynamic shapes)  maintenance cost: windscreen fractures decrease, new assembling systems. The main objectives of this project are:  to identify the new possible solutions of glazing for increasing safety & recyclability, reducing weight (up to 30%), improving thermal & acoustic comfort (EUCAR MP strategic objectives: improved quality, reliability & comfort; reduction in fuel consumption, increased recyclability),  to find out common methodologies for glazing characterization between car and glazing manufacturers to create a common data base, especially for developing new glazing solutions (EUCAR MP stratogic objective: reduce material cost).  to optimize the glazing choice by a better understanding of possible conflict between glazing features(EUCAR MP strategic objective: improved quality reliability & comfort);  to test optimized solutions for glazing on case study cars that will allow to validate the new methodologies and the benefits obtained by the optimization of glazing parameters (new solution demonstrators). Several methods of glazing characterization are present in the state of the art and most of them are of common use between car and glass manufacturers (especially those addressed to law requirements). However, in some specific fields very little work is available. No attempt has been made to optimize the glazing for all its performances and to un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Late-stage evolution of the lunar magma ocean: an experimental study' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The origin of the Moon has been attributed to a giant impact involving a Mars-sized asteroid and the proto-Earth. Energy liberated in this catastrophic event was sufficient to melt a substantial portion of the Moon, a likely cause of a global “Lunar Magma Ocean. This LMO developed early at ca. 4.5 Ga and its crystallization appears to have produced an anorthositic crust and deep cumulate rocks forming the lunar upper mantle, known from their product of partial melting: mare basalts. Direct evidence on how the LMO evolved as it cooled and crystallized remains a major issue. Petrologic models for the solidification of the LMO are derived mainly from thermodynamic phase relationships. The crystallization sequence predicted by these models is olivine, opx ± olivine, olivine + cpx ± plag, cpx + plag, cpx + plag + ilmenite. However, the exact composition of late-stage products during the crystallisation of the LMO remains poorly known. The timing for plagioclase accumulation by flotation, that probably occurred at the top of the LMO to form the lunar crust, is undoubtedly related to the density of the magma. It is rather uncertain whether plagioclase has floated throughout its crystallization story or only at precise degree of evolution when a maximum magma density was reached. What occurs during this critical early period of the Moon differentiation sets the stage for all subsequent events. The objective of this project is to perform new experiments in a range of pressure, with sophisticated equipments allowing the control of important parameters such as starting compositions, temperature and oxygen fugacity. New models for how the LMO evolved as it crystallized during its late-stage evolution will be developed and constrained with observations on mare basalts. How do starti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Role of miRNAs in brown and white adipose tissue differentiation and function' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Mammals have two types of fat: brown and white, with opposing functions. The white adipose tissue (WAT) is an important regulator of the whole body homeostasis that also serves to store energy in form of triglycerides (TGs). The main function of the brown adipose tissue (BAT) is to catabolize lipids in order to produce heat, a function that can be induced by cold exposure or diet. Disruption of the normal differentiation or development of the WAT causes ectopic lipid storage and severe pathology in both humans and experimental animals. Increased BAT development leads to increased energy expenditure without causing dysfunction in other tissues, and is associated with a lean and healthy phenotype, outlining the manipulation of the fat stores as an obvious therapeutic objective. With the proposed research we will identify miRNAs and other factors that regulate BAT and WAT differentiation and function. We will distinguish the miRNAs that specifically regulate brown or white adipogenesis and are expressed in the respective precursors, and establish them as signatures for either cell type.  We will also identify the molecular mechanisms of action of the identified miRNAs in regulation of adipose tissue differentiation and metabolism. Using in vitro and in vivo systems, linage tracing studies, transgenic animals, as well as cohorts of human patients, we will determine the origin of the beige cells within the SAT, establish their importance in the regulation of metabolism in vivo, and develop novel strategies to induce the brown fat differentiation and function. Finally, we will discover ways to exclusively silence miRNAs in the brown fat will that will allow us not only to investigate the miRNAs function specifically in the brown fat, but also to develop new strategies for tre