RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Circulating microRNAs in lynch syndrome' under Horizon 2020.

assistant: **Concept**

Blood-based cancer biomarkers have become important research targets and together with the recent development of liquid biopsy methods and analysis, they have become interesting future tools for cancer diagnosis. The cell-free small non-coding circulating RNA particles, namely microRNAs (c-miRs) that associate with cancer development, have been identified and tested to be used for cancer screening, diagnosis, tumor subtype classification, chemo- or radio-resistance monitoring, and outcome prognosis. Here we use whole serum c-miR clusters from patients with hereditary cancer syndrome, called Lynch syndrome,  as a biomarker and we develop machine learning-based algorithms to diagnose and predict cancer occurrence in this patient cohort.  We also functionally test how these c-miR clusters effect lynch syndrome linked to tumor growth. This interdisciplinary project combines clinical, cell biological and bioinformatic research and it will reciprocally transfer knowledge between research, Tiina Jokela and host institute, University of Jyväskylä and secondment institutes; University of Helsinki and Helsinki University Hospital.  The proposed project support researcher Tiina Jokela to also gain transferable independent research skills and support her future career goal to become the leader of her own academic research group in the cancer research field.


**Keywords:** c-miR, miRNA,  lynch syndrome, machine learning, patient-derived organoids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Off site emergency management' to be submitted under Fifth Framework.

assistant: **Abstract**

The main objective of this thematic cluster is to provide an adequate platform for a timely data and information exchange between a number of projects pertaining to the European Commission's radiation protection key action programme. Although these projects belong to different areas, they have a complimentary character. Furthermore, they serve the objectives of the programme in the area of off site emergency management.This thematic cluster will serve a number of purposes: keep coherence, exchange of information, co-operation, help maintain the focus on broader objectives of the programme, strengthen the link between the user and developer communities, and last but not least, help define new areas where R&D work is needed bearing in mind the general objectives of the research programme.It is expected that most of the objectives will be achieved through active collaboration among the various groups, participation in workshops, data and information dissemination via both synchronous and asynchronous discussion groups and through a dedicated world-wide-web portal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Diversity Outdoors: Embodied ethnoracial inequalities and outdoor recreation in Europe' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This project seeks to investigate how social inequalities are embodied through a comparative analysis of participation in outdoor recreation in Europe. Outdoor recreation  such as hiking, climbing, swimming, but also birdwatching and camping  is as a pivotal arena where racialized encounters and practices manifest. Given the current international attention to diversity and (lack of) anti-racism in Europe on the one hand, and the understudied emerging grassroots outdoor movements that challenge these discourses on the other, it is essential that we better understand the embodiment of ethnoracial inequality and its intersections with religion, gender, class and ability. This project undertakes a comparative ethnographic study of ethnoracial embodiment in outdoor recreation in Western-Europe, while asking the questions: What are the effects of ethnoracial embodiment on sociocultural diversity in outdoor recreation? How are bodies constituted as in or out of place in outdoor recreation in Europe? How is diversity in outdoor recreation influenced by local, national and transnational discourses and imaginations? What is the role of ethnoracial affinity and opposition in experiences of participating in, and contesting the status quo of outdoor recreation?The central objective is to gain insight in the commonalities and socio-cultural distinctiveness of how ethnoracial inequalities are embodied, experienced, and contested across Europe. It does so by analysing the embodied, sensorial dimensions of racialization (and its intersections) in outdoor recreation and developing a theorization on ethnoracial embodiment. The concept sensory ecology helps innovatively analyse identity-based outdoor groups and activities, outdoor recreation policies and discourses between local movements,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Developing Talent in Science: Breaking the Gifted Education Taboo'.

assistant: **Objectives**

The proposed project Developing talent in science: Breaking the gifted education taboo seeks to gain new insight of how to address gifted students needs in inclusive education (IE) systems. IE systems, described as one school for all aim to ensure education is accessible for all students, however in reality have focused on the needs of average or lower-achieving students. Gifted education (GE) has been considered elitist, even taboo, and thus the needs of gifted students have been largely neglected in IE policies and schools pedagogical strategies. However, individuals gifted in science are key persons to develop responses to societal challenges and to increase innovation and economic competitiveness  if the education system allows them to develop their potential into actual competencies. Neglecting gifted students needs may also lead to negative consequences such as underachievement, bullying, and depression. The project will include the perspectives of gifted and regular students, parents and science teachers, and compare the results from Sweden and Finland using mixed methods. It will examine how gifted students socioemotional and learning-related needs are supported in inclusive science classrooms and what are gifted students and their parents lived experiences of specific GE strategies, such as acceleration and grouping  two potentially very effective but understudied and underused strategies in inclusive GE. The project will also examine how science teachers support gifted students learning with regard to competence development teachers have had or wish to have, and it seeks to find and showcase the best practices in inclusive GE. The project will produce highly relevant scientific knowledge from the IE context and improve teacher education; strong research-based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enhancing the EOSC portal and connecting thematic clouds' in the context of a Horizon 2020 call.

assistant: **Objectives**

EOSC Enhance pursues 4 objectives:1: Enhance the service provider interface and incorporate new services and resources into the EOSC catalogue2: Accelerate the deployment and uptake of EOSC services and resources3: Increase user demand for EOSC services and resources via portal improvements and development4: Enabling easier access to thematic clouds services and dataEOSC Enhance will improve and enhance the discoverability of scientific services and data resources by further developing and widening the EOSC catalogue. This will be done through the integration of additional services and data resources (notably the ESFRI clusters and thematic and geographic clouds) as well as further technical enhancement of the functionalities for service providers (Open APIs, AAI) and users (search and comparison tools, etc.). Quality reports will be provided to service providers. We will facilitate interoperability and discoverability of services and resources across scientific disciplines by linking up thematic and regional/national service providers (public and commercial), gateways, aggregators and marketplaces. The EOSC Portal will apply the emerging EOSC Rules of Participation (RoP) and will focus on processes, specifications, guidelines, tools and APIs to support service and resource providers in making them interoperable. We will consolidate the EOSC Portal as the point of access for researchers through the facilitation and continuous enhancement of findability and discoverability -by appropriately design of the UI for example- inherent building blocks addressed in the EOSC Enhance project - that will make this possible. The critical technical aspects and features of the EOSC Portal will be discussed and agreed with ESFRI clusters to enhance interoperability and avoid frictions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The development of a vaccine against pregnancy-associated malaria' (PAMVAC).

assistant: **Concept**

Pregnancy-associated malaria can cause infant mortality, premature delivery, low birth weight and anaemia and death in the mother. It is a major global public health problem. Our RTD project emphasises the development of a vaccine to protect pregnant women and their newborns from the adverse effects of malarial infections. We will carry out an extensive characterisation of the complex phenomenon of parasite adhesion and sequestration in the placenta, through which we hope to identify parasite protein antigen domains responsible for binding of infected erythrocytes. We will determine the functional relevance of receptor-ligand interactions and will generate structural information to facilitate the development of anti-adhesion vaccines. We will also focus on elucidating the immune mechanisms involved in protection, identifying anti-parasite antibodies and evaluating cytokine production in the placenta in response to malarial infections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of the Gas-Solid Vortex-Rotor Reactor' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project includes Proof-of-Concept research, as well as preparation and submission of a new patent application. The intention of the current proposal is to develop a novel gas-solid reactor that drastically reduces the limitations of these reactors. Moreover, novel fields of applications will be sought. This new Intellectual Property of UGent will be a subject of its following licensing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Human Muscle-Bone Organoid-on-Chip to Study Bone Mechano- Adaptation via Optogenetic Control' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Fragility fractures and osteoporosis erode independence and drive healthcare costs. Muscle activity supports bone through mechanical strain and myokines such as irisin, but current models cannot separate these signals or recombine them with the precision needed to design effective, human-relevant regimens. What is missing is a platform that can measure, predict, and actively steer osteogenesis.BONE-TUNE builds that link. It develops a human muscle-bone organoid-on-a-chip where mechanical loading and muscle-derived biochemical cues are delivered either independently or synchronised, while a bone microtissue reports its state in real time. It integrates optogenetic muscle rings for light-controlled contractions and a biodegradable, microstructured bone microtissue under perfusion to enhance biological fidelity. Using calibrated inputs and live readouts, a compact computational model is trained to translate any candidate “exercise recipe” into a single osteogenic index. The model then closes the loop, automatically adjusting loading and myokine pulses to hold the tissue in an anabolic window as properties evolve, an adaptive “exercise machine on a chip.”The objectives are to quantify how muscle-derived strain and myokines act alone and together; to deliver a validated guidance tool that predicts outcomes for unseen regimens and yields a mechanics×myokines×timing response map; and to demonstrate real-time control that outperforms the best open-loop schedule. Outputs include a reusable chip and dataset, open software with look-ups from target strain to actuator settings, and practical dosing rules, including rest, that rehabilitation and preclinical teams can test.By shifting mechanobiology from description to prescription, BONE-TUNE provides human-relevant, model-guided mec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New Strong Forces at the Large Hadron Collider' under Seventh Framework.

assistant: **Concept**

The Large Hadron Collider (LHC) will hopefully uncover some of the fundamental mysteries of particle physics: What is the origin of the observed asymmetry between electromagnetic and weak interactions ? What is the origin of electron and quark masses ? Does the Higgs boson exist ? What is the dark matter of the universe made of ? What is the origin of the observed matter-antimatter asymmetry ? In order to answer (some of) these questions from a theoretical standpoint several models have been proposed. Among these the most thoroughly analyzed are the ""standard model"" and  ""supersymmetry"". A very intriguing possibility is that the symmetry between electromagnetic and weak interactions is broken dynamically by a new kind of strong force, known as ""technicolor"" (TC). Although very appealing, TC has received less attention than competing theories, because its strong nature makes it more difficult to analyze. However in the past few years a lot of progress has been made to understand strong dynamics, and we are in a position to make specific predictions about the signatures of TC at colliders. Based on the recent findings, we aim to analyze the most relevant aspects of TC phenomenology at the LHC, and propose new mechanisms for fermion mass generation in the context of TC theories.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Functional Ion Conductance and Sensing'.

assistant: **Innovation**

This proposal presents unique approaches for the functional characterization of charged interfaces and interfacial phenomena at the nanoscale, through the implementation of an innovative and quantitative ion flux imaging technique. The scientific scope of the project involves the development of a frontier high resolution electrochemical imaging technique, based on scanning ion conductance microscopy that will be capable of probing the nanoscale structure and charge heterogeneity at almost any kind of interface. This represents a major fundamental science aim, that will also open new horizons for the exploration of nanomaterials, including novel electrode materials (graphene and graphene oxide, carbon nanotubes), as well as for imaging self-assembled nanostructures of metallic nanoparticles (NPs). The methodology will allow us to determine the microscopic physicochemical characteristics of individual NPs and their assemblies at soft interfaces and reveal the reactivity of electrocatalytic substrates for fuel cell reactions. We will be able to identify active sites on catalysts and relate these directly to structure - of huge benefit for the understanding and rational design of future functional materials. The research proposal is highly interdisciplinary, and there is a natural fit between the Fellow’s profile and activities at the Host Warwick group. The proposal draws on Fellow’s strong multidisciplinary background in chemistry, mathematical modelling and microtechnology, especially in understanding charged interfaces and nanoscale ion flows, that will be married with the world-leading research on innovative imaging techniques being developed at Warwick. With considerable support and world-leading expertise from the Host group and its collaborators, this project will p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Tele-Ophthalmological Services - Citizen-centred Applications (TOSCA)' (TOSCA), addressing dissemination and exploitation.

assistant: **Impact**

TOSCA is a merger of major European initiatives aiming at the reduction of blindness by the use of citizen-centred telemedical applications in ophthalmology. The focus is on diabetic retinopathy (DR) and glaucoma, which are the most frequent causes of blindness in Europe. Besides the suffering of patients affected, both diseases cause immense costs. TOSCA provides a technical platform based on European and other international standards. On this platform, telescreening services for early detection of DR and glaucoma will be implemented. Image processing and reference image databases improve the efficiency of DR screening and support quality assurance. Compliance and quality of care for glaucoma will be improved by home monitoring, telecommunication among home-based patients and physicians, and a patient-centred glaucoma information system. Services will be implemented and evaluated at three test sites.Objectives:TOSCA's overall objective is to establish citizen/patient centred telematic services in ophthalmology. TOSCA will contribute to the reduction of blindness caused by diabetic retinopathy (DR) and glaucoma which are the most frequent causes of blindness in Europe.In detail TOSCA will:1) Establish a telemedical platform based on European technological and terminological standards. TOSCA unifies the data and information exchange among the main European initiatives in tele-ophthalmology2) Improve early detection of DR by implementation of telescreening services, automatic image processing, and a reference image database3) Improve early detection of glaucoma by implementation of telescreening services4) Improve compliance and quality of therapy by implementation of a home-monitoring system and a patient-centred telecommunication system for glaucoma5) Improve compliance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'House Poetics. An 'assemblage' approach to the production and transmission of value in Bronze Age Crete.' to be submitted under Horizon 2020.

assistant: **Abstract**

The Project explores the fundamental social question of the creation of value, by investigating House Societies in Bronze Age Crete (3100-1200 BC). Houses are understood as intergenerational, locus-bound social groups, holding an estate of material and symbolic wealth, transmitted along a real or imaginary line, legitimized by kinship or affinity, or both. Because of their distinct focus on the creation and transmission of value, Houses are an ideal framework for answering this research question, but their longevity makes it difficult to explain change. By fusing Houses with the philosophical and sociological premises of Assemblage theory, which argues that social entities are not fixed but constituted by relationships between humans, non-humans and materials that can territorialize and deterritorialize value, the project creates a new social ontology which perceives Houses in a constant state of becoming, continuously affecting and being affected by the changing social world they inhabit. The methodological advantage of this interdisciplinary model, combining philosophical, sociological, archaeological and scientific perspectives, will be demonstrated empirically through the integrated use of GIS spatial analysis and material culture analysis, in a series of case studies (selected on the basis of availability of good contextual information for primary data and a large corpus of published evidence) targeting three strategic scales of House formation and interaction: a single site (Petras), its regional context (East Crete) and their broader geopolitical networks (the Aegean and the East Mediterranean). Using GIS to explore Houses as Assemblages will offer an original integration of spatial, material and social scales, which can revitalize our understanding of past socie