RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Contribution to the development of phasing techniques for macromolecular crystallography', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content  The project is part of an ongoing programme aiming at the integration of all macromolecular crustallographic phasing techniques within a single computational scheme based on Bayesian inference, and implemented within computer programs currently being developed at the host institution. In particular, the proposed research will focus on two phasing techniques for macromolecular structure determination: 1. Bayesian Density Modification, which will be carried out by automatic definition and updating of molecular envelopes, and by detection and exploitation of non-cqstaUographic symmetry elements; 2. Simultaneous refinement of a partial structure by Maximum Likelihood and completion of it by Maximum Entropy, incorporating any available experimental sources of phase information. Training content (objective, benefit and expected impact) The objectives of the proposed research are all macromolecular in content the applicant primarily desires to gain a thorough training in macromolecular crystollographic At the same time, both the tasks listed above build on the applicant's strong expertise in high-resolution crystallic studies of accurate charge densities: the macromolecular work will thus benefit from a valuable fresh input from his past work in that field.The integrated treatment of these two sources of structural information will improve the phasingI power of conventional crtstallographic techniques and hence ease the determination of difficult macromolecular crystal structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated time and cost-saving analysis of proteolytic activity and inhibitory provision of patient's plasma as the basis for prognosis of acute, subacute and chronic thrombo-haemorrhage complications in inflammation' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

As a result of this proposal research the controversial subject regarding the stability (firmness) of the El-a 1PI complex in human plasma is to be solved.The answer of value will be received, if the El-a1PI complex, due to its instability, is the reason of the key plasma proteins inactivation, or this inactivation is a result of imbalance between the low level of a1PI and high leucocyte elastase activity.The proposal investigation lies in the range of the Fourth Framework Programme - under the heading of Measurement and testing", 8.3 Health and safety, as far as the proposed measurement method is to improve the comparability of results used for in vitro diagnostic and therapeutic purposes, and the results of this method have the valid reference data used in decision-making in the clinical field.The biochemical diagnosis of severe inflammation with disseminated processes, such as extensive trauma, peritonitis and septicaemia, predicting possible complications (acute respiratory distress syndrome, disseminated intravascular coagulation and multiple organ failure), is not properly possible in clinical laboratories of NIS nowadays. Meanwhile, there is a good reason to assume that the most destructive neutrophil enzyme, which disturbs the regulation of processes of blood coagulation and fibrinolysis, is leucocyte elastase (El). Some laboratories of CCE use the immunoenzyme (ELISA) method for estimation the concentration of the complex of leucocyte elastase with its main plasma inhibitor - alPI. This method has been suggested and developed in the beginning of 80th by researchers of Munich University, and is designed for the control of neutrophil activation and their degranulation. But this method has not become commonly accepted in clinical laboratories of both CCE and NIS b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Particle physics models of the early Universe and observational constraints from the cosmic background radiation' to be submitted under Sixth Framework.

assistant: **Abstract**

The aim of this project is to fully exploit the observational data of modern cosmological experiments for constraining those theoretical models, such as string theory and quantum gravity, proposed in the attempt to understand the fundamental behaviour of Nature. High-energy physics can leave its imprint in the large-scale structure of the Universe during the primordial stage of its evolution, so that microcosm reflects into macrocosm in very non-trivial ways. The observability of effects predicted by these models, and their discrimination from the standard general relativistic picture, are very topical and still unsolved issues, to be confronted with the most recent or upcoming experiments, especially those involving the observation of the cosmic background radiation. The main objectives are twofold. On one hand, we wish to establish one or more reasonable theoretical setups involving string-inspired features (such as extra dimensions) and give either positive or negative evidences for their existence. The in coming flow of new data, especially from WMAP and the Planck mission, will permit us to constrain cosmological scenarios with an unprecedented degree of precision. A clear answer in this respect would boost the physical research and collaboration in many o f its sectors. On the other hand, a refinement of the methods of analysis employed in cosmology for extracting predictions on the observables is necessary in order to compare standard four-dimensional and high-energy scenarios. The starting points are the inflationary setup, encoded in a scalar action recast in the slow-roll formalism, and the patch approach, which generalizes the Friedmann equations to an arbitrary Hubble expansion. While the former framework seems convenient to describe an early era of in flati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Patterning Spin-Wave reconfIgurable Nanodevices for loGics and computing.' (SWING), addressing dissemination and exploitation.

assistant: **Impact**

Spin-waves, i.e. propagating perturbations in the spin arrangement of magnetic materials, are envisioned to revolutionize the way information is carried and processed due to their multiplexing capability and absence of Joule losses. By bringing together the complementary expertise of “CUNY Advanced Science Research Center” (USA) and “Politecnico di Milano (PoliMi)” (Italy), the ‘SWING’ project addresses two major issues of current nanoscale magnonics: the efficient guidance of spin-waves in nanostructured materials and the study of spin-waves at the nanoscale.At CUNY, “Thermally assisted magnetic scanning probe lithography” (tam-SPL), recently conceived and demonstrated by the applicant, will be further developed and employed for nanopatterning magnonic devices in magnetic multilayers grown at PoliMi. In such devices, spin-waves will be efficiently guided and manipulated by defining reconfigurable topological features, such as magnetic domain walls, in continuous films, avoiding any detrimental scattering due to the physical interfaces created by conventional lithography. Furthermore, a novel, versatile tool for the nanoscale study of magnons will be realized, by combining Nitrogen-Vacancy magnetometry and scanning probe microscopy. Advanced magnetic characterization via optical methods, experiments at Brookhaven Synchrotron and access to the cutting-edge CUNY NanoFab facility will be pivotal complements in view of the research objectives. During the incoming phase, the acquired expertise and technologies developed at CUNY will be transferred to PoliMi, aiming to realize fully reconfigurable nanoscale magnonic logic devices.‘SWING’ project aims to push magnonics forward, by means of an interdisciplinary approach which combines the excellent competence of the host organi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Paediatric research centre - focusing on effective child treatment (PERFECT)' (PERFECT).

assistant: **Innovation**

PERRFECT will act on the basis of the Children' s Memorial Health Institute (CMHI) . Aim of PERFECT is to establish a better position of CMHI in integrated Europe by networking , twining and constructing joint research projects with similar paediatric centres from EU, as well as from NAS area. The PERFECT will act in the fields of chronic, rare diseases, inherited metabolic disorders, mitochondrial diseases, congenital heart diseases, solid tumours, and nutrition treatment. Work plan consists of 13 work packages: Ten related to personal exchange, organisation of seminars, workshops and symposia, one related to economics and management, one with post-graduate training to attract young researchers, and one with project co-ordination and management. Three years of PERFECT activities will raise the CMHI to the new higher level of quality in research, education and European integration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Chromatin dynamics during DNA replication' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Chromatin assembly is a fundamental cellular process necessary for the maintenance of genome integrity and transcriptional programs. Understanding the effect of DNA replication on histone protein dynamics is also a prerequisite for understanding the role of chromatin in epigenetic inheritance. Epigenetic phenomena are thought to influence cellular differentiation and cancer formation, as well as the impact of environmental factors on early development and later predispositions to disease. While epigenetic inheritance of chromatin components is, in theory, accepted as the driver of such phenomena, chromatin state inheritance per se has only been demonstrated for a few specific cases. Not much is known about histone “inheritance” beyond the facts that bulk maternal histones distribute equally among the daughter strands and are diluted two-fold after replication with newly synthesized “unmarked” histones, and that the majority of H3/H4 tetramers do not split before reassembly. We have shown previously that maternal nucleosomes stay on average within 400bp of their original binding site, implying that any potentially heritable chromatin encoded information, has to be inherited in ~1kb blocs, as smaller nucleosome domains would rapidly be diluted by new nucleosomes. I propose to develop high throughput systems for directly measuring movements of histones and chromatin regulators  during genomic replication in S.cerevisiae to determine, how chromatin states survive the perturbations associated with replication. We will determine locus specific differences in the spread of maternal nucleosomes after replication, the effects of leading and lagging strand replication on nucleosome positioning and maternal nucleosome distribution, the renewal dynamics of posttranslational histone
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Continuous and Efficient Cooperative Trust Management for Resilient CCAM' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

CONNECT addresses the convergence of security and safety in CCAM by assessing dynamic trust relationships and defining a trust reasoning framework based on which involved entities can establish trust for cooperatively executing safety-critical functions. This will enable both a) cyber-secure data sharing between data sources in the CCAM ecosystem that had no or insufficient pre-existing trust relationship, and b) outsourcing tasks to the MEC and cloud in a trustworthy way. Beyond the needs of functional safety, trustworthiness management should be included in CCAM’s security functionality solution for verifying trustworthiness of transmitting stations and infrastructure. CONNECT will build upon and expand the Zero Trust concept to tackle the issue of how to bootstrap vertical trust from the application, the execution environment and device hardware from the vehicle up to MEC and cloud environments. This includes measuring the system when instantiating network functions and determining the integrity and origin of software. Trusted Execution Environments (TEEs), as sw- or hw-based security elements, will be essential to establish a verifiable chain of trust throughout the entire application stack of the host vehicle, as well as protecting data in transit, at rest and in use. By coupling the Zero Trust security principle with the need of “Never Trust, Always Verify”, CONNECT bootstraps vertical trust for all users, devices and systems in the CCAM ecosystem by enabling continuous authorization and authentication prior to be granted access to data or resources. Through TEE-enabled “Chip-to-Cloud"" assurances and verifiable chain of trust, CONNECT reaches its full potential: not only does it mitigates risks stemming from the Zero Trust CCAM environment but also ensures resili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Determining multi-level led causes and testing intervention designs to reduce radicalisation, extremism and political violence in north-western Europe through social inclusion'.

assistant: **Concept**

In recent years, research on extremist identity politics and political violence in Europe has focused on patterns of violent radical Islamism and far-right radicalisation among young men. This research has brought to the fore problems of identity, belonging, inter-generational change, alienation, marginalisation, inequality, masculinity and miseducation. These findings point to matters of space and place that compound existing exclusionary discourses based on ethnicity, religious identity, socio-economic status and politics. Moreover, far right movements and violent Islamists not only have similar breeding grounds but they arguably also feed off each other’s rhetoric and activism in particular local urban areas. However, there are significant gaps in understanding the interplay between these different forms of local extremism, as no study has yet to investigate the synergies or reciprocity between Islamist and radical right extremism in a comparative European context. Moreover, there is no detailed understanding of the relationship between the individual and structural factors that also take into consideration the psychosocial circumstances affecting already vulnerable people. There remains a fundamental lack of appreciation of the wider struggles of social inclusion that affect the radicalisation experience in urban areas. It is a central concern for all vulnerable people concerning radicalisation, where questions of personal and political identity combined with issues of intergenerational change affect the paths individuals can take. DRIVE will produce a range of policy-orientated research findings to better understand how exactly social inclusion impacts on radicalisation for far right and Islamist groups in different parts of North-Western Europe, the targeted group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PAssive and electro-optic polymer photonics and InP electronics iNtegration for multi-flow Terabit transceivers at edge SDN switcHes and data-centER gateways' (PANTHER).

assistant: **Concept**

Multi-rate, multi-format and multi-reach operation of optical transceivers is important, but it is not enough for next generation terabit products. What is still missing to make these products viable is a solution for the flexible control of this enormous capacity at the optical layer and its distribution among a number of independent optical flows. PANTHER aims to provide this solution and develop multi-rate, multi-format, multi-reach and multi-flow terabit transceivers for edge switches and data-center gateways. To this end, PANTHER will combine electro-optic with passive polymers and will develop a novel photonic integration platform with unprecedented potential for high-speed modulation and optical functionality on-chip. It will also rely on the combination of polymers with InP gain chips and photodiode arrays, and on the use of the InP-DHBT platform for driving circuits based on 3-bit power-DACs and high-speed TIA arrays. Using 3D integration techniques, PANTHER will integrate these components in compact system-in-package transceivers capable of operation at rates up to 64 Gbaud, operation with formats up to DP-64-QAM, spectral efficiency up to 10.24 b/s/Hz, capacity using a dual-carrier scheme up to 1.536 Tb/s, and flexibility in the generation and handling of multiple optical flows on-chip. This impressive performance will come with a potential for 55% power consumption reduction and more than 60% cost/bit reduction, taking into account benefits from the material system, the integration concept, the operation at high baud-rates and the possibility for IP traffic offloading. PANTHER will incorporate the transceivers in edge switch and data-center gateway architectures and will evaluate their performance in lab and real-network settings. Finally, PANTHER will devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ADVANCED INFORMATION SYSTEM FOR MULTINATIONAL DRUG ENFORCEMENT', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

AVENTINUS will underpin European police and government law-enforcement in the drugs field. It will enhance existing information systems for prevention and detection of offences, also providing multilingual facilities. This user-friendly application will support collection and analysis of composite data, from a variety of sources and in several languages, for interrogation by investigators in their own language in which the search result will be profiled and presented. It will integrate information indexing and extraction over distributed sources, accurate information retrieval and multilingual and multimedia data handling techniques.Progress on the Project The user requirement study has established that police and intelligence units need to be supported in a number of ways: - rough translation of foreign language documents to assess if they are worth accurate translation - assistance in processing documents so as to assimilate relevant information into local systems - aid to analysts in formulating searches, by offering additional search terms to expand a query and through natural language access to structured and textual databases - access to foreign language databases by translating the search request and re-translating the texts found To provide this support, AVENTINUS focuses on three main areas: - translation support using term substitution components, translation memory technology, and machine translation integrated. - information processing support with both information extraction (fact extraction) and intelligent indexing. Information extraction finds entities related to illegal activities (e.g. names of suspect organisations and individuals, narcotics, places, etc.), composing templates and scenarios, to be recorded in structured databases. Intelligent indexing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a new technology for backfilling decorated films with thermoplastics' under Fifth Framework.

assistant: **Concept**

The objective of this project is the development of a new process for a one-step backfilling technology for plastic parts. In this project the performing and punching of the film shall be realized inside the tool. This shall help to reduce the investment costs and to enhance the applicability for SMEs. Normally, a decorated film is preformed, punched out, inserted into the tool and backfilled.The advantages of backmoulding films are one-step production and decoration during injection molding and avoiding the emission of harmful substances as compared to other processes. Disadvantageous is the complex harmonizing of the single processing steps until the moulding, which can lead to higher scrap rates or up to the non- applicability of this technology. The further developing of this technology shall eliminate these errors and save tooling costs. First attempts to form the film inside the tool were successful. Areas of application: see enclosure.