RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Compact methanol reformer test-design construction and operation of a 25 kW unit' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives Drive systems for cars using a Polymer Electrolyte Membrane Fuel Cell (PEMFC) and an electric motor can lead to increased energy usage efficiency and substantially reduced emissions compared with the best drive systems based on the internal combustion engine. Methanol is today the best energy carrier for such systems, when taking into account availability, cost and safety aspects into account. The overall goal of this project is the design, construction and operation of a compact methanol reformer (CMR), including gas cleaning in combination with a PEMFC stack and the interfaces as part of a passenger car drive system. Technical Approach The project can be divided into the following main tasks: Design and construction of a CMR (Haldor Topsoe A/S) Development of a gas cleaning unit based on membranes (Haldor Topsoe A/S) Design and construction of a catalytic combustor unit (KFA, Jülich) Assembly and tests of integrated CMR, gas cleaning unit and PEMFC stack (KFA, Jülich) Development and manufacturing of a PEMFC stack (SIEMENS) Evaluation of results HALDOR TOPSØE A/S (HTAS) will design a compact reformer corresponding to 25 kW electricity integrated with a catalytic converter, which provides heat for the endothermal reforming reaction. A prototype will be constructed and delivered to KFA, Jülich. HTAS will also develop a gas cleaning unit based on membranes selective for hydrogen. KFA will design, construct, test, and deliver a catalytic combustor for the prototype. KFA will also be responsible for assembling the total system and carry out test with it, including testing its dynamic behaviour. SIEMENS will construct a PEMFC stack generating a power of 1 kW and conduct endurance tests with H2/air. This stack will be delivered to KFA, where it will be combined wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Evaluation of Osteoarthritis Progression in a Patient-Specific Manner using Magnetic Resonance Imaging and Computational Modeling'.

assistant: **Innovation**

BackgroundOsteoarthritis (OA) is one of the most prevalent disorders of the musculoskeletal system. In OA, articular cartilage degenerates and its structure and mechanical properties change, but monitoring or predicting the progression of OA has not been possible. Magnetic resonance imaging (MRI) is a potential tool for the imaging of joint tissues, estimating cartilage structure and diagnostics of OA, whereas joint loading and estimation of stresses/strains within joint tissues necessitates computational modeling. It would be a major breakthrough if one could develop a technique where, based on MRI and computational modeling, prediction and evaluation of OA progression of a patient under a certain loading condition would be possible.Objectives1) to combine MRI with computational modeling for the estimation of stresses and possible failure points within human knee joints, and 2) to develop second generation adaptive models of articular cartilage for the prediction of altered tissue structure and composition during OA progression. For the model validation, cartilage structure, composition and biomechanical properties as well as cell responses in situ are characterized. At the end of the project these main aims will be merged 3) to estimate the effect of loading on cartilage degeneration during the progression of OA in a patient-specific manner.SignificanceCombining MRI information of joint tissues with computational modeling, we develop a tool to evaluate the effect of different interventions on stresses in human joints. By combining this tool with an adaptive model that can estimate the effect of loading on cartilage composition and structure, we hope to be able to predict changes in cartilage properties during OA progression in a patient-specific manner several years a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New geochemical approach to reconstruct tropical palaeo-atmospheric dynamics'.

assistant: **Innovation**

Tropical climates are changing rapidly in the most populated regions of the planet. The changes largely arise from alterations in the Hadley circulation driven by natural and anthropogenic factors, whose relative roles and temporal variability are unclear. These knowledge gaps are in part due to the shortage of methods to study the atmospheric circulation before the advent of instrumental and satellites observations, and compounded by the contradictions between models and palaeo-data.The aim of the project is to develop an innovative palaeo-proxy approach to investigate the natural range of variability of the Hadley circulation during past episodes of extreme warmth and cold. The approach relies on the exploitation as climate proxy of an untapped but widespread material in marine sediments: windborne pyrogenic carbon (PyC) derived from savannah and grassland fires in the tropics. Through the geochemical and isotopic spatial characterization of PyC, along with the analysis of mineral dust in the modern tropical deep ocean, and a PyC biogeochemical model, we will build an interpretative framework of PyC deposition in deep-sea sediments. Its application in Pliocene-Pleistocene sequences from the Atlantic and the Pacific will allow the reconstruction of past meridional and zonal shifts in the Intertropical Convergence Zone and the Southern hemisphere westerlies, and provide new constraints on the natural variability of the Hadley circulation and associated hydroclimates.  PALADYN is possible thanks to the combination of cutting-edge geochemical and satellite data, and GIS methodologies, with in-depth interdisciplinary expertise on the palaeoclimatic study of marine sediments. We will provide new important datasets of windborne deep-sea PyC for testing and refining predictio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Establishment and maintenance of cell polarity and tissue architecture in the lateral-line system of the zebrafish' (2002-2006).

assistant: **Concept**

The establishment and maintenance of cellular polarity are critical for organ function. In addition to the ubiquitous apicobasal axis, many epithelial cells display a second polarity axis within the plane of the tissue, referred to as planar cell polarity. The orientation of hair-cell stereocilia in the inner ear represents a striking example of planar polarity in vertebrates. Although many of the proteins involved in the interpretation of the polarising cues have been identified, the mechanistic bases of t heir activity are not known.The motivation of this project is to understand the molecular and cellular mechanisms that generate the precise architecture of a sensory epithelium, with an emphasis on planar cell polarity. Hair cells provide an excellent mod el for cell-polarity studies. Experiments will be done using the anatomically simple mechanosensory organs of the lateral line in the zebrafish, whose hair cells display a stereotyped planar polarity pattern. I will first investigate the cellular mechanism s that lead to the planar polarisation of hair cells during lateral-line development. Second, I will study how the polarised organisation is recovered after hair-cell regeneration.Preliminary evidence suggests that functional properties of progenitor cell s within the organ are determinants of hair-cell polarisation. I shall test this hypothesis by tracking protein localisation patterns during hair-cell development in vivo, in wild type and mutant specimens with randomised planar polarity. To facilitate the se analysis, I will use transgenic reporter lines with specific expression in the lateral line, in combination with fluorescently tagged proteins that distribute asymmetrically in hair cells. This innovative approach shall lead to a deeper understanding of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spintronic-Photonic Integrated Circuit platform for novel Electronics' (SPICE) targeting Horizon 2020.

assistant: **Abstract**

The main objective of SPICE is to realize a novel integration platform that combines photonic, magnetic and electronic components. Its validity will be shown by a conceptually new spintronic-photonic memory chip demonstrator with 3 orders of magnitude higher write speed and 2 orders of magnitude lower energy consumption than state-of-the-art spintronic memory technologies. This enables, e.g., future petabit-per-second processor-memory bandwidths, required in a decade from now, and highly energy-efficient exascale datacenters with reduced carbon footprint. Such a versatile memory will result in so-called Universal Memory: one technology for all memory applications ranging from cache to storage.The methods to achieve this are based on the recent discovery of magnetization reversal by short optical pulses. SPICE will bring this technique to the integrated circuit level by first developing free magnetic layers that can be optically switched into a magnetic-tunnel-junction layerstack, with optically transparent top contacts. These layers will then be processed into spintronic memory elements that can be electrically read. A novel short-pulse switching architecture will be designed and implemented in a silicon photonic integrated circuit. This photonic switching layer will then be combined with the spintronic memory layer to achieve an optically switched 8-bit memory with write efficiency of 600 fJ per bit: the proof of concept of the technology.The novelty of SPICE is the convergence of the emerging fields of opto-magnetism and spintronics with electronic and photonic integration technologies. The ambition is to develop this technology in such a way that it can be compatible with future mature electronics fabrication processes, for real-world applications beyond 2025, thereb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'mRNA cap regulation and function in CD8 T cells', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

CD8 T cells are vital for our response to infection, directly killing infected cells and stimulating other cells of the immune system.  Major health problems world-wide involve deregulated T cells, including lymphomas, leukaemias, auto-immune disorders and organ transplant rejection.  Damaging deficiencies of T cells are found in old-age.  T cell development and response to pathogens is driven by regulated transcription and translation, however the mechanisms orchestrating this gene regulation are largely unknown, and are likely provide novel opportunities for therapeutic intervention.  Our preliminary data reveals that a potent structure in gene expression, the mRNA cap, which co-ordinates RNA processing and translation initiation, is crucial for the development and activation of CD8 T cells.  Regulation of mRNA cap formation is a novel concept in gene regulation in T cells, and also has not been studied in vivo previously.  Our findings suggest the existence of an mRNA cap code, in which the different mRNA cap methylations regulate different genes and cellular functions.  In TCAPS we will reveal how the mRNA cap code orchestrates CD8 T function.  We will determine how the mRNA cap structures are regulated during CD8 T cell differentiation using the latest mass spectrometry technologies.  We will determine the role of each mRNA cap methyltransferase in CD8 T cell gene expression during differentiation, using conditional knock-out mice in conjunction with enzyme biochemistry, RNA sequencing and quantitative mass spectrometry.  We will determine the biological function of the mRNA cap methyltransferases in CD8 T cell survival and activation using immunological assays.  TCAPS will also provide the first insight into the role of the mRNA cap code in vivo.  The mRNA cap cod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Fragments of Aristotle: A Reconstruction of his Lost Works' (FragArist), addressing dissemination and exploitation.

assistant: **Impact**

One of the greatest minds of antiquity was no doubt Aristotle. He left a lasting impression on Western civilization, influencing among others the Founding Fathers in designing the US constitution. But what many do not know is that only a fraction of his works survive. Those preserved through medieval transmission - his so-called esoteric works - go back to college lectures and were intended to be used by his small circle of students. But Aristotle also wrote many works for a wider audience, which survive only in ""fragments,"" i.e. citations in later authors, and a number of epitomes. In fact, what is preserved today is not what Aristotle was famous for throughout most of antiquity or even what he intended to be known for. Yet modern research focuses almost exclusively on the esoteric works. The result is that the Aristotle one meets in contemporary scholarship is really only the Aristotle of the preserved school writings. In order to truly understand his views on politics, ethics, poetry, rhetoric, logic and the soul or his approach as a scientist and historian, we must also study the lost works. The fragments are essential to understand his philosophy and assess his impact on Western thought. FragArist aims to shift the attention back to what were initially his most important works and establish a new understanding of Aristotle by reconstructing and interpreting his lost works. We will combine methods taken from philology, papyrology, philosophy, ancient history and Digital Humanities and apply pioneering editing techniques and the latest cutting-edge imaging techniques. For the first time we will also incorporate the fragments found in Syriac and Arabic sources. We will create a radically new perspective on Aristotle's personality and elucidate his influence on later
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Demonstration of INTElligent grid technologies for renewables INTEgration and INTEractive consumer participation enabling INTEroperable market solutions and INTErconnected stakeholders'.

assistant: **Innovation**

InteGrid’s vision is to bridge the gap between citizens, technology and the other players of the energy system. The project will demonstrate how DSOs may enable all stakeholders to actively participate in the energy market and distribution grid management and develop and implement new business models, making use of new data management and consumer involvement approaches. Moreover, the consortium will demonstrate scalable and replicable solutions in an integrated environment that enables DSOs to plan and operate the network with a high share of DRES in a stable, secure and economic way, using flexibility inherently offered by specific technologies and by interaction with different stakeholders. To achieve these objectives, a complementary partnership covering the distribution system value chain has been established. The consortium includes three DSOs from different countries and their retailers, innovative ICT companies and equipment manufacturers as well as customers, a start-up in the area of community engagement and excellent R&D institutions. InteGrid’s concepts and approaches are based on the these two elements: 1. the role of the DSO as system optimiser and as market facilitator and 2. the integration of existing demonstration activities in three different regions allowing to move from single solutions to an integrated management at a higher scale while focusing on the scalability and replicability considering current and evolving market (and regulatory) conditions.  The three conceptual pillars – proactive operational planning with DER, business models for flexible DER, information exchange between different power system actors – offer an opportunity to maximize the economic, societal and environmental gains from the combined integration of DRES and flexible DER.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'IP1 Traction TD1 and Brakes TD5 – Phase 2'.

assistant: **Innovation**

The PINTA2 Project (IP1 Traction TD1 and Brakes TD5 – Phase 2) will address the two key topics highlighted in the Shift2Rail Call topic S2R-CFM-IP1-01-2018 – Development of concepts towards the next generation of traction systems and management of wheel/rail adhesion, namely Traction and Adhesion Management. PINTA2 will continue, fully in line with PINTA Phase1,  to work on Traction & Adhesion  improvements of seven technical and economical KPIs of the Traction system that have been agreed and defined in PINTA (fully in line with S2R KPIs). These performances will  be improved on five different train applications having different constraints, needs and specificities, from tramway to HST, including metro, sub-urban, regional trains. In particular, Traction sub-project will address the following KPIs: 1) Line capacity increase through weight, volume and noise savings of Traction equipment. 2) Reduction of Maintenance costs  via higher reliability/availability and optimized for maintenance Traction components. 3) Railway system LCC reduction via higher energy efficiency and optimized capital cost of the Traction systems.On Brakes Adhesion side, the work will lead to the achievement of a number of important objectives such as · higherTRL levels of improvement of braking degradation limit in poor adhesion condition · Management of all adhesion conditions in a way that brake distances are optimized · Improvement of the overall train safety, which relies substantially on the management of the wheel/rail contact · Reduction of wheel Life-Cycle-Costs (LCCs) through optimized wheel/rail contact in braking The activities will contribute in developing new performance solutions for Adhesion. The work done in PINTA2 will consist in higher achievement ( up to TRL6) to prepare the fina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The development of a control strategy for schistosoma haematobium in the Senegal river basin' (1994-1998).

assistant: **Innovation**

* To carry out an up to date assessment of the current situation on prevalence and morbidity of urinary (and intestinal) schistosomiasis in the Lower Middle and Upper parts of the Senegal River Basin (SRB) and identify new emerging endemic foci.* To determine the factors which influence seasonality of transmission in Senegal and Mali. This information will be highly relevant in assessing the best time for intervention procedures. * To determine the correlation between the development of immunity to Schistosoma haematobium infection and exposure to infection, in areas with different types of transmission (short / long) and in different types of foci (old / recent).* To determine the effects of agriculture and water development on the spread of schistosomiasis in the SRB.* To evaluate reinfection patterns and immunity development according to different timings of treatment.Expected OutcomeIt is expected that the data generated from these studies will give a clear lead as to the most effective control strategy for schistosomiasis in the Senegal River Basin.These studies will generate important information for future vaccination trials, as it is possible to adapt vaccine formulation (presentation, type of vector) to the different transmission patterns in the field.It is anticipated that the south-south axis will be strengthened through regional cooperation.* A survey will be carried out in the Upper part of the SRB (Bakel, Manantali) to assess the current situation on prevalence and morbidity of schistosomiasis and the compatibility of Schistosoma haematobium with the local intermediate hosts (transition zone?). Suitable villages in Mali will be selected for the further studies.* Epidemiological, morbidity and control studies. During a two year period longitudinal immuno-ep