RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Layered semiconductors and hybrid systems for quantum optics and opto-valleytronics' (LASSO).

assistant: **Concept**

A new resource for quantum information processing has emerged recently in the form of the valley pseudospin in layered transition metal dichalcogenides. By virtue of strong spin-orbit and Berry curvature effects, these non-centrosymmetric crystals provide a quantum optical interface between spin- and valley-polarized electrons and circularly polarized photons. Such valley-contrasting optical selection rules in turn establish means to address the multivalley quantum resource all-optically. At this interface, where light meets valley quantum states of matter, the proposed research will aim at tailoring and mastering electron-hole-pair excitations and their coupling to photons in layered transition metal dichalcogenide semiconductors, heterostructures and hybrid systems. The project will combine semiconductor monolayers with ferroelectric and ferromagnetic supports to achieve synthetic opto-valleytronic functionality of substrate-modified excitons for the development of novel linear, non-linear and chiral quantum optical elements. Reciprocally, interfacial effect of the substrate on the valley dynamics of monolayer excitons will be utilized for the development of quantum-enhanced imaging of ferroic domain textures to facilitate fundamental studies of phase transitions in condensed matter systems. In parallel, we will develop on chip-circuitry to control long-lived dipolar excitons in hetero-bilayer semiconductors. Finally, light-matter quasiparticles in the form of exciton-polaritons with weak and strong mutual interactions in monolayer- and heterobilayer-cavity systems will be created, engineered and condensed at ultra-low temperatures into a macroscopic ground state. The realization of interacting polariton gases and condensates, paired with the opto-valleytronic phenome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dyn mat', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The development of advanced new materials and their engineering on nanoscopic length scales will be an important key-technology of the next century. The technological properties of these materials are not only determined by their structure but also by their electronic and vibration dynamics. Examples of technological relevance are friction accompanied by phonon excitation, heat transfer in microelectronic devices and magnetoelastic effects in magnetic microstructures. The more the dynamical properties are expected to govern the function and performance of future devices, the more important are the efficient methods for their characterization.Synchrotron radiation (SR) has become an ideal tool in this field over the recent years. The ultra-high brilliance of third-generation SR sources initiated enormous progress in established X-ray methods and enabled the development of completely new types of spectroscopies for the study of condensed matter dynamics. A number of dedicated beamlines are available for inelastic scattering studies at SR facilities in Europe. So far, only very few research groups have used inelastic scattering methods in applications so that their strength is not common knowledge. The main objective of the EuroSchool is that potential users learn about the advantages of these novel techniques and that scientists from solid state physics, materials science, chemistry and biology join together in an multidisciplinary event and share their expertise. The EuroSchool will allow to bring SR specialists in contact with researchers that have detailed knowledge on advanced new materials and can rise the scientific questions to be worked on. The European scale of the event will enable the most efficient use of the inelastic research capabilities in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'INCREASING LUTETIUM PRODUCTION, WHILE LEVERAGING METABOLIC IMAGING TO ENHANCE THERANOSTICS EFFECTIVENESS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Selective targeting of therapy with antibody-radioisotope combinations have led to major advances in treating cancers that are resistant to common therapies, such as castrate-resistant prostate cancer. Adding Lutetium-177-PSMA (Lu-177-PSMA) to standard care significantly prolongs survival. However, the increased use of Lu-177-based therapies has resulted in an increased demand for this isotope, leading to shortage risks.In addition, despite the success of Lu-177-treatment, ~30% of patients do not benefit from treatment, but do suffer from side-effects.ILLUMINATE, will improve the availability and use of theranostics across its value chain by taking a hybrid approach: 1) Imaging capabilities will be improved by implementing novel, broadly applicable, scalable and highly effective Metabolic Magnetic Resonance Imaging (MeMRI), which are expected to give better and faster insight into treatment responses, allowing better patient stratificationand treatment personalisation; 2) The availability of Lu-177 will be fortified by improving its manufacturing process, and by developing sustainable production methods to help meet the general need for radio-isotope based therapies and increase EU autonomy. The ILLUMINATE consortium (industries Philips, NRG, Bracco, TeslaDC, Wavetronica, Lygature, SDN, EuroBioImaging, and the Univerisities of Torino, Lund, Amsterdam UMC, Klinik Essen, coordinated by UMC Utrecht) uses the example of Lu-177-PSMA as a showcase clinical trial in 150 patients for broadly applicable innovative technologies in the field of theranostics and radioisotope manufacturing for oncology.


**Keywords:** Metabolic MRI, oncology, prostate cancer, theranostics, medicinal radionucleotide production
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Free-space Optical Communications for Aerial-sateLlite networks' under Horizon Europe.

assistant: **Concept**

With currently 3 billion people lacking access to broadband internet worldwide, European operators are struggling to fill the white areas with insufficient or nonexistent connectivity. In light of the early promises of 6G wireless networks, it is tempting to consider non-terrestrial networks as complementary to the ground-based radio and fiber infrastructure. However, radio frequency-based satellite systems are nearing their capacity limits and cannot be scaled further.  Free-space optical technology is a natural alternative to deliver greater capacity and to better address data security needs by leveraging quantum communications. The first optical intersatellite links are being deployed in commercial networks at relatively low data rate (10 Gbps). However, once the most important remaining research challenges are resolved, they could rapidly expand and serve as a catalyst for the development of a new communication backbone in the sky, consisting of aerial and space optical nodes at different altitudes. The overarching aim of the FOCAL project is to train a new generation of highly qualified doctoral candidates in developing innovative aerial and space optical wireless technologies that will provide future telecommunication networks with ubiquitous connectivity, resilience, and quantum-proof security. In addition to contributing to the fundamental understanding and technical know-how of such networks through co-supervised individual research projects, FOCAL will train talented and innovative researchers with multidisciplinary expertise and skills that are desirable in this European industrial sector. This will be achieved through a combination of theoretical and hands-on research training provided by a unique consortium of 16 academic and 10 industrial partners from 8 c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular mechanisms of Akt-induced Myocardial contraction' (2002-2006).

assistant: **Concept**

The serine/threonine kinase Akt, a key downstream kinase of the IGF1/PI3K pathway has a profound effect on cardiac function both in vivo and in vivo. Transgenic mice over-expressing an active mutant of Akt induced an increase of inotropism in vivo and in vitro and of lusotropism in vitro, indicating the role of Akt in physiologic hypertrophy.New data from us show that Akt induces the phosphorylation of phospholamban (PLB), a critical regulator of SERCA2a, the pump responsible for Ca2+uptake from the sarcoplasmic reticulum (SR) at Thr-17, a residue phosphorylated by Ca2+/Calmodulin-dependent kinase 2 delta (CAMK).Thus, our working hypothesis is that Akt activates CAMK in the SR compartment and that the inotropic effects of Akt are partially or totally dependent on this effect. Preliminary data show also that stimulation of cardiomyocytes (CMCs) with IGF-1, which externally activates Akt, induces CAMK-dependent PLB phosphorylation.The aims of our project are therefore- To characterize the role of CAMK in mediating the effects of Akt on inotropism and lustropism, through biochemical and functional experiments on cardiac myocytes and on isolated SR vescicles. The relevance of AKT-dependent CAMK activation at the level of organ physiology will be addressed by generating inducible and tissue-specific knockout mice of both CAMK 2 delta and Akt2. We will generate also a knockout mouse deleted in the nuclear localization signal of CAMK2 delta to determine the importance of subcellular localization in CAMK signalling- To establish whether Akt can improve cardiac function in heart failure. For this, MLP knockout mice, a model of dilatative cardiomyopathy, will be crossed with E40K Akt transgenic mice or treated with Akt by myocardial gene transfer.As a whole, our study aims to def
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modeling Breast Cancer in 3D Cell Culture Systems and Mice' in the context of a Seventh Framework call.

assistant: **Objectives**

Breast cancer is one of the most common malignancies among women in the western world. In the last two decades, major advances have been made in our understanding of breast cancer that have resulted in a decline in breast cancer mortality. To advance these improvements, research efforts need to be directed to a series of areas, including breast cancer genetics and identification of new targets for therapy.Accordingly, the proposed research aims to characterize mammary cells during different stages of carcinogenesis, targeted treatment and during their dormant period that might lead to tumor relapse:•We will delineate cooperating lesions in breast cancer to develop better strategies for targeted therapy.•Our approach to understand the origin of tumor initiating cells and how and why they differ from normal breast stem cells will open new avenues in tumor treatment and prevention.•Characterization of the residual cells after treatment will greatly improve our understanding of the mechanisms of oncogene dependence and may lead to more effective therapeutic strategies to prevent breast cancer relapse.To investigate these objectives, we will utilize tractable in vivo mouse mammary tumor models in parallel with 3D cell culture systems of primary mammary cells derived from these animals. This novel, combined approach allows to retrieve more detailed mechanistic insights with respect to cellular organization, position and fate of specialized cells within a mammary acinus and -at the same time- to follow the in vivo model for overall phenotypes.The EMBL Mouse Biology Unit offers me the unique chance to implement these novel approaches in the European Research Area (ERA). Employment of sophisticated 3D cell culture systems in combination with transgenic mouse models, are expensiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Control of an invasive predator for conservation: Spatial density dependent dispersal in American mink' (DISPERSE).

assistant: **Concept**

The introduction of alien species into some areas has had a devastating impact on the native biodiversity as they cause fundamental changes in ecosystems. In most cases, eradication is impossible; however, it is necessary to control alien species in order to preserve the native species. In many European countries a catastrophic decrease in water vole numbers has been observed after American mink invasion. In Scotland, water voles disappeared from a majority of lowland rivers and streams, although some small populations still persist in the uplands in area not invade by mink. Our hypothesis considers reducing the magnitude and spatial scale of mink encroachment to the uplands in order to protect water vole population.The main goal of this project is to re-create and maintain areas where water vole populations can survive in protected refuges on the basis of metapopulation and population dynamic theory. We will investigate the influences of density and demographic parameters of a lowland American mink population on mink dispersal into the uplands, and the effect of culling operations in reducing dispersal rate. The present project will also determine whether culling operations that are being implemented in a collaborative effort between conservationists and shooting interests in NE Scotland have any impact on the population dynamics of mink. We will build a parameterising basic spatial stage structured model of mink population dynamic used in recent statistical developments - Markov Chain Monte Carlo. We will combine field surveys, radio-telemetry, live trapping and mink genotyping with an analysis of trapping records, sex- and age-structure, and reproductive status of mink carcasses collected from sport shooting in estates in NE Scotland. The main project output will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biocatalytic upgrading of natural biopolymers for reassembly as multipurpose materials' under Horizon 2020.

assistant: **Concept**

The BioUPGRADE action unites functional genomics and material science advances, to galvanize the sustainable transformation of nature’s major structural polymers into a cascade of high volume and specialized bioproducts. Technology ready results (TRL 4-6) are anticipated, serving as an innovation launchpad that tackles climate change while revolutionizing the materials used in our daily lives.  The action is differentiated by its: 1) emphasis on upgrading nature’s main biopolymers for use in performance advantaged products with emergent properties; 2) pursuit of cell-free, biocatalytic technologies that leverage the design principles and finesse encoded in surface-acting enzymes and non-catalytic proteins, which will permit fine-tuning of natural polymer structures for customized applications that can not be achieved through dominating thermochemical approaches; and 3) creation of novel, fully bio-based materials based on controlled assembly of tailored biopolymer components, guided by new capacity to probe biopolymers and resulting materials from nano to macro scales. BioUPGRADE will apply advances in computational biology to mine untapped information in escalating genomic and proteomic datasets; introduce a bio-customize framework that stretches well beyond current synthetic biology concepts; and establish a structure-function matrix for tailored biopolymers and new assemblies. Key project deliverables include: 1) application-driven functional screens critical to breakthroughs in bio-technologies for materials engineering, 2) an innovational, biocatalyst toolbox of surface-acting proteins designed for bio-based materials engineering, and 3) protocols for controlled assembly of tailored biopolymers into fully bio-based materials, from sustainable textiles to personal h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'THE WATERWISE HUB: AN EXCELLENCE HUB ON WATER IN THE CIRCULAR ECONOMY' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

The WaterWise Excellence Hub is a vibrant, action-oriented initiative that aspires to serve as a catalyst for R&I (creation and uptake), business development, and knowledge dissemination for water in the circular economy (CE). It leverages CE principles to rethink and transform water management in Romania, Greece and selected Western Balkans and Eastern Partnership countries (MD, SB, AL, NM and UA). WaterWise perceives the water sector not only as sustainable, but also regenerative, emphasizing closed-loop systems, optimal resource use, and reduced waste, in line with EU policies and RIS3 strategies. It is based on a quadruple helix model of innovation, and works at the nexus of technology acceleration, entrepreneurial support and R&I, boosting water innovation in the Region and beyond. To this effect the Hub’s partners co-create an R&I Strategy, an Action and Investment Plan, a FundFinder Portal, a Strategic & Tactical Decisions Toolbox as well as an Operational Decisions Toolbox, setup Water Tech Challenges, develop and launch an Innovation Accelerator, produce LLL Training Courses, create and share a Knowledge Hub and develop and deploy a Mentoring Scheme through a bottom up approach in collaboration with a wide range of key actors and stakeholders across the region.  The Hub is empowered by its strong partnership that brings together actors from government, R&I-driven universities and research centres, funding bodies, business, water utilities, SME associations and civil society to create services tailored for post-project sustainability and real-world impact.


**Keywords:** Water innovation, Circular and distributed water solutions, water in the circular economy, research to market, water innovation acceleration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Printing Electro-Tomography' in the context of a Horizon Europe call.

assistant: **Objectives**

3D printing is literally building our future in realising components and parts which cannot either be manufactured with standard techniques (milling, lathing) or for which the scale does not justify the use of molding techniques which require longer time and are only convenient for a high production scale. The problem with current 3D printing is the tradeoff between speed and precision: if we want to print fast in additive manufacturing, it is more difficult to know what physically happens with the deposition, and increasing speed is always at the cost of precision. This is mostly due to the fact that the deposition process is basically in Open Loop. Currently there is a strong demand for in-situ measurement techniques to enable real time feedback, where the newest camera based techniques only allow for measurements on the outer surface of prints. The proposed innovation wants to create real time feedback by using easily implementable electrical impedance measurements during the printing process together with conductively doped material, measuring multipoint impedances among points on the substrate and the nozzle to possibly realize a tomographic description of the print. This intrinsically cheap method can be used pervasively and has ground breaking potential for both the professional and consumer 3D printing market. Prints will be of higher quality, printing will be faster and losses will be reduced. This will increase the usability, reliability and throughput of 3D printing which are the major concerns in this manufacturing technology for both the professional and the consumer market. The idea has been patented and industry has already confirmed strong interest. With the support of the ERC-PoC, the PI and his multidisciplinary team will be able to address the questio