RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dipeptide-Repeat Vaccine to prevent ALS and FTD in C9orf72 mutation carriers' (DPR-VAX).

assistant: **Innovation**

Neurodegenerative diseases are triggered by protein aggregation in the CNS, but developing therapies has been challenging. Since key disease mechanisms change during disease progression, halting further neuron loss has not been achieved and may not even improve the symptoms and survival. Causal therapy is most realistic for monogenic disease variants.About 10% of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases are caused by repeat expansion in the C9orf72 gene. We have shown that the expanded repeat is translated into multiple aggregating dipeptide repeat (DPR) proteins. Poly-GA, the most abundant DPR species, is a key driver of downstream pathology. A poly-GA vaccine reduces aggregates and almost completely prevents motor deficits in our mouse model. With additional validation and safety experiment we will generate a pharma-ready data package for rapid preclinical and clinical devel-opment of the vaccine as first-in-class drug for prevention of ALS and FTD in C9orf72 carriers. The parallel development of suitable biomarkers to show clearance of DPR aggregates in vivo will greatly accelerate clinical trials. Thus, we will optimize our published immunoassays to allow more sensitive detection of DPRs in patient CSF. Moreover, we will develop our patented DPR monoclonal antibodies into a PET tracer. The solid data package is complemented by internal and external expertise in business development and regulatory affairs to shape an attractive business proposition and create value. ERC-PoC funding will allow us to present the opportunity to potential partners in large pharmaceutical companies and reputable venture capitalists for licensing or spin-off generation. Another proven strategy in the rare disease space would be collaboration with patient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'IDENTIFICATION AND EXPLOITATION OF COMPETITIVE PROPERTIES OF SOURDOUGH STARTERS FOR THE PRODUCTION OF TASTEFUL BREAD' in the context of a Fourth Framework call.

assistant: **Objectives**

The production of bread requires leavening of the dough. Before baker's yeast was available sourdough was the only biological leavening agent. Sourdough obtained from spontaneous fermentation of flour, water and salt was refreshed every day. The sensorial properties of such traditionally prepared sourdough bread are highly appreciated.Given the diversity of strains of lactic acid bacteria and yeasts which has been already reported in sourdough the use of molecular taxonomy is required in order to avoid mis-identification and in order to obtain more clarity on metabolism in different environments. Starch, proteins, pentosans are the main components of flour. Hydrolysis of these macromolecules by enzymes provides substrates for the lactic acid bacteria and yeasts. This in turn leads to modification of the physico-chemical properties of the dough and determines the final quality of the bread. It is the aim of this proposal to study how the metabolism of pentosans polyfructosans and proteins can affect :- the microbial ecology of sourdough;- the physico-chemical properties and machinability of dough;- the organoleptic quality and shelf life of bread;- the preparation of starters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Increased leather performance and improved enveronmental aspects of leather manufacture through the application of specific enzymes in the beamhouse' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The production of leather from raw skins and hides is a chemical intensive process. Reducing the chemical requirements and time required for processing would increase the profitability of the leather produced. Initial research has shown the that the use of enzyme can reduce chemical requirements and processing times and effluent things. Despite the promised advantages to be gained from the use of enzymes, their use in the leather industry is limited to one specific function, the use of proteases to remove non-collagenous materials from the skin during early processing. This is partly due to the conservative nature of the industry. The introduction of enzymes to the industry has, however, been piecemeal and non-rationalised. As the leather industry is relatively small, it tends to adopt technologies and chemicals from other industries rather than develop them for the specific requirements of the sector. This often results in products that are not ideally suited to the task and performances which are less than ideal. The application of enzymes, particularly lipases and cellulases, fall into this group. It is likely, however, that the development of effective enzyme protocols will reduce processing costs and times, reduce effluent problem and hence increase the profit margin on the final product. It is the aim of this project to : 1. Assess the efficacy of various enzymes at different stages of leather processing. These are to include the use of cellulases to remove dung from hides and skins in the wash, the use of proteases to remove soluble proteins such as dermatan sulphate and hyaluronic acid during soaking and liming and the uses of lipases to remove natural fats. 2. Evaluate the benefits of enzyme application in the reduction of both processing time and chemicals. 3.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Blood flow induced thrombosis and stenosis due to cannulation – an interdisciplinary study', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In extracorporeal organ support (ECOS), one or more organ functions fail and are replaced by an artificial device. Kidney failure requires hemodialysis, at least until transplantation. Temporary lung- and/or heart-failure may be treated by Extracorporeal Membrane Oxygenation (ECMO). About 1.5 Million patients require hemodialysis worldwide. ECMO has an essential life-saving role during the ongoing COVID-19 pandemic, as during the Influenzae H1N1 pandemic in 2009. In ECOS, two or more accesses are used; one for blood drainage and another to return oxygenated blood. The flow rate in the cannula and the cannulated blood vessels is often significantly higher than physiologically experienced. The high flow velocity implies larger forces (stress) acting on the blood cells and the vessel walls. Thromboembolism and morphological and mechanical changes in the affected blood vessel are common complications in ECOS. This project focus on the impact of blood flow on these complications. Patient-specific data (CT, MRI and Ultrasound based) will be used to construct laboratory and simulation relevant frameworks. Set-ups for measurement of flow and mixing in-vitro will be used. Simulations will include modeling of transport of chemical species and blood cells along with modeling of platelet activation and risk for thrombus formation. The different tools will enable a considerably better understanding of the underlying pathological processes. The results will support further model development of these processes and facilitate improved cannulation techniques and new devices. These propositions are to be assessed by our clinical partners.  Therefore, the project group includes, fluid mechanical expertise, and also clinical specialist in nephrology, intensive care/ECMO, and radiology. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Highly-complex and networked control systems' (HYCON2) targeting Seventh Framework.

assistant: **Abstract**

ICT developments both enable and also enforce large-scale, highly-connected systems in society and industry. Knowledge to cope with these emerging systems is lacking. HYCON2 will stimulate and establish the long-term integration of the European research community, leading institutions and industry in the strategic field of control of complex, large-scale, and networked dynamical systems. It will interconnect scattered groups to create critical mass and complementarity, and will provide the necessary visibility and communication with the European industries. HYCON2 will assess and coordinate basic and applied research, from fundamental analytical properties of complex systems to control design methodologies with networking, self-organizing and system-wide coordination. HYCON2 has identified several applications domains to motivate, integrate, and evaluate research in networked control. These domains are ground and aerospace transportation, electrical power networks, process industries, and biological and medical systems. Benchmarking will serve as a tool for testing and evaluating the technologies developed in HYCON2 and for stimulating and enforcing excellence by the identification and adoption of best practices. In particular, two show-case applications corresponding to real-world problems have been selected in order to demonstrate the applicability of networked control and the need for research in control. As no substantial technological breakthrough can be achieved without preparing the proper cultural background, a further important objective of HYCON2 is to spread and disseminate excellence through multi-disciplinary education at the graduate and undergraduate level. The proposed research, integration and dissemination program will make Europe both the prominent sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'New Carbon Fibre Reinforced Copper Matrix Composites for a Unique a nd New Generation of Electronical and Electrical devices'.

assistant: **Concept**

Industrial need is given for high performing materials in electronic packaging systems as well as in other electronic and electrical systems for devices working under high current densities and high thermal load. The project's aim is to develop new Carbon fibre reinforced Copper matrix composites whereby the thermal expansion is controlled and the thermal conductivity is enhanced. Besides a high stiffness and very good electrical conductivity is also expected. The unique combination of the low and adaptable coefficient of thermal expansion with extraordinary high thermal conductivity will make the material useful for heat sinks applications, in particular for electronics (Hybride Modules, Electronic Relays) and for electrically conducting springs. The envisaged material and its use are expected to give the European Industry in this field a lead for e.g. miniturizing electronics. For that purpose 3 possible production routes (Powder Metallurgy, Diffusion Bonding of Cucoated fibres, Infiltration of C fibre preforms with Copper melt) will be developed and be brought from laboratory to demonstrator scale. Suitable test pieces will be characterized with respect of their properties and investigated in demonstrator tests at the end users. Final evaluations about efficiency and economics are expected for outlining and initiating a new product" line. In the projects are involved 6 partners from 4 different EU members, 2 partners from CCE countries will participate additionally with essential contributions. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Artificial User' (2021-2027).

assistant: **Concept**

PROBLEM: Despite decades of research on human-computer interaction (HCI), the problem of how to predict human performance with a given user interface (UI) is unsolved. Existing computational models are limited in scope or require large datasets or expert input. Instead, empirical methods are used that are costly and error-prone. OBJECTIVE: This project establishes the foundations of simulation intelligence in HCI through computational rationality. Given a design and a task environment, a simulator generates human-like moment-to-moment behavior autonomously, from which key metrics can be computed, i.e. for learning, performance, and ergonomics. ”Artificial users” can be commanded using natural language without modeling expertise. APPROACH: We seek a breakthrough through the theory of computational rationality that would dramatically expand the models’ scope and actionability. The theory posits that interactive behavior is an emergent consequence of a control policy adapted to internal bounds (cognition) and rewards. While previous work has demonstrated progress, scope has been limited to simple sensorimotor tasks and required reward engineering. This project will study the principles of computationally rational agents that learn skills like humans, can operate autonomously and yet be commanded via natural language. We design a workflow for building dramatically larger models via self-supervised pretraining. IMPACT: We develop a strong complement to existing evaluation methods in HCI. The pushes forward generative modeling in HCI by combining theory-driven causal assumptions about people and modern ML, while being deployed directly in high-fidelity simulators. This allows dealing with novel task environments with higher accuracy. This will be a leap forward in application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'GAS IMPORT FLOATING TERMINAL' to be submitted under Sixth Framework.

assistant: **Abstract**

An offshore floating LNG storage terminal is proposed in which a large hull is moored to the seabed by means of a turret mooring system that allows the terminal to weather-vane freely in accordance with the prevailing weather conditions. The terminal will receive LNG from normal LNG carriers that berth alongside the terminal; such operation requires calm sea conditions to allow the offloading. This proposal offers such facility in an innovative way by designing the hull and mooring system such that transv erse thrusters are able to rotate the hull so that it is held transversely to the direction of the prevailing seas, so that the hull acts like a breakwater and creates a calmer area in its lee, in which the LNG carrier berths, discharges and unmoors. To further dampen the seas in the lee of the terminal, the hull will be equipped with large horizontal and properly optimised skirts, at keel level. The effectiveness of this has already been proven in principle for a semi-protected sea area on the new floa ting quay in Monaco harbour, which was recently designed and deployed by DORIS Engineering but the design needs to be advanced to a further level, to enable feasibility to be proven for offshore application. The proposed concept will give advantages to th e European industry competing at international level to provide new solutions for importing LNG in densely populated areas in a safe, economical and efficient manner. The project is fully relevant to Objective 2 of the work programme Advanced design and production techniques", in particular research domain 2.2."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'IPv6 ITS Station Stack for Cooperative Systems FOTs' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

ITSSv6 aims at developing a reference open-source IPv6 ITS Station stack available to European and national third parties (projects, industry and academia) using IPv6 for Internet-based communications in Field Operational Tests (FOTs) of Cooperative Systems. The IPv6 networking capabilities of the ITS Station under standardization at ISO TC204 WG16 (CALM) and ETSI TC ITS are extended with additional IPv6 features required for operational deployment of Cooperative Systems i.e. enhanced performance, embedded security, remote management of deployed systems and ease of configuration. New features and their perfect integration within the ITS Station architecture (particularly ITS Station management and ITS Facilities) are specified. The project takes as an input the FP6 CVIS core communication software and additional modules developed by FP7 GeoNet. It produces an enhanced IPv6 ITS Station stack adapted to operational use in large scale FOTs to the benefit of a variety of Cooperative Systems applications which require Internet communications (road safety, traffic efficiency and infotainment types of applications). The new software is validated on a basic open platform with recommended physical interfaces (802.11p and 3G). The project gathers key partners from the CVIS and GeoNet projects and key expertise in the specification and development of the IPv6 software. Reasonable resources are allocated for the training, portability and integration of the released ITSSv6 stack to a selection of third parties involved in FOTs. Prospective users are constantly informed of the progress of the project through a user forum and regular newsletters, software version releases and bug fixes. Project partners actively participate to the continuing standardization effort and to fill up gaps
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Science Revealed!'.

assistant: **Innovation**

With the “Science Revealed!” (SR) project, the Research Promotion Foundation with the collaboration of all the major research institutions aim to organise a successful Researchers’ Night event in Cyprus. The objectives of the event are to contribute: (1) towards the public recognition of researchers, and (2) towards developing a positive attitude of the younger generations regarding the researchers’ profession and its contribution to society. The objectives will be accomplished by reaching a large number of people through a suitable awareness campaign in order to convey the messages of this initiative and by attracting them to an event where they will have the opportunity to meet and interact with the researchers in person, in an educational yet light-hearted and joyful environment, on a Friday evening. The event will be organised in Nicosia at the Famagusta Gate. The programme of the event will consist of several activities, both entertaining and educational, mainly related to popular trends and combining a line of themes such as culture, art, theatre and music with science. The activities include a hands-on exhibition with interactive experiments, “Met and Greet” session, a Science Communication Competition (The Science-Factor) within high school and university students, a “Superheroes Uncovered” workshop to explain through simple interactive/presentations Superheeroes’ super powers and a Theatre/Musical related to mathematics.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chimeric Antigen Receptors (CARs) for Advanced Therapies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Chimeric antigen receptors (CARs) are artificial surface receptors that can be introduced into somatic cells by genetic engineering and that act as recognition molecules like antibodies or T-cell receptors. In this respect, CARs are increasingly used for cellular therapy to redirect T-cells specifically towards killing of cancer cells. Recent success stories of cancer therapy with CAR modified T-cells have raised enormous scientific and public expectations to cure severely ill patients. However, there are still many obstacles to overcome for translation into clinics because the technology for GMP-compliant manufacture of genetically modified cellular products is extremely complex and expensive. Moreover, CAR therapy needs to be improved with respect to off-target activity, safety and potency. Consequently, the envisaged project is overall aiming at a particular technological breakthrough in cellular cancer therapy by delivering a comprehensive CARAT platform explicitly tailored for automated, easy-to-handle and cost-efficient manufacture of CAR-modified ATMP. Specifically, we aim:(a) to implement unique next-generation cell processing tools like the CliniMACS Prodigy(b) to develop advanced enabling technologies to obtain more effective and safer cellular products by improved gene delivery and innovative CARs design(c) to assemble tools and technologies towards an integrated CARAT process for automated GMP-compliant manufacture of gene-modified T-cells(d) to demonstrate proof-of-concept and regulatory compliance(e) to disseminate broadly applicable, simplified CAR T-cell technologiesIn summary, our vision is to overcome current hurdles for translation of cellular therapies and to elevate them to the next level of standard-of-care thus serving patients with so far incurab