RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'UNalphabeting the Central Dogma of Life' (LIFE-19), addressing dissemination and exploitation.

assistant: **Impact**

This proposal aims to construct a bacterial strain LIFE-19 which relies solely on 19 amino acids to build all its proteins. While all living cells known to human beings produce proteins from the same 20 coded amino acids, the study of origins of life imply that earlier cells may have functioned with a smaller alphabet. This is thought-provoking in the present biological context, wherein each of the 20 serves a distinct and vital role. Although many scientists have engaged in theoretical exercises involving the reduction of this amino acid alphabet, the inherent biological intricacy and a lack of suitable tools have impeded experiments on an organismal level. This project seeks to mutate all the tryptophan (Trp) protein sites in a minimal Mycoplasma genome template. Trp stands out as both one of the scarcest and one of the evolutionary youngest members of the protein alphabet. Here, we will engineer Trp out of a minimal genome in a 2-stage process. Initially, semi-automated gene editing will target all individual Mycoplasma Trp-sites concurrently, using broad randomization schemes (capitalizing on the PIs expertise). This will allow us to compare Trp dispensability across the proteome and select the most viable Trp-substituted protein variants. Second, the selected mutations will be combined to write a new LIFE-19 genome using a bottom-up synthesis. LIFE-19 will lay the next steppingstone to our understanding of lifes limits. We will be able to get a glimpse into what cells probably went through billions of years ago, when they teetered on the border between life and nonlife. With the reduced number of building blocks, LIFE-19 will also generate an important step towards a cellular chassis with minimal energetic demands and therefore key inventory in Synthetic Biology re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Young Homeownership' under Horizon Europe.

assistant: **Concept**

Consider a household looking to buy a house. In attractive locations, this household competes with other buyers to purchase their desired property since the number of listed properties is limited. In this scenario, what is the impact of subsidizing a given group? What is the impact of a change in public policy that affects one group more than others? Do households respond to the policy by changing their preferences? YoHo (Young Homeownership) builds on a simple yet powerful insight: if a buyer is competing against other buyers from the same group, then changing financial conditions for that group will not change their access to the housing market but may affect how much they can pay. The insight that YoHo proposes to formalize is that if a policy targets a large share of buyers, subsidizing them will likely not lead to higher homeownership rates but to rising prices. Moving beyond market-level outcomes, YoHo will further dig deeper into the potential side effects for young buyers, such as limited access to attractive locations. YoHo will combine Norwegian register data, natural experiments, and theoretical modeling in line with the state-of-the-art housing literature to answer questions of large importance for society, the economic situation for households, and future research into affordability and homeownership. Access to the housing market is an ongoing societal challenge in many countries that involves the general public, policymakers, and academics. The work in YoHo is at the core of this challenge, with the potential to make a meaningful contribution to the debate. The research will be conducted under Professor Florian Heider's guidance at the Leibniz Institute for Financial Research SAFE, which aims to produce original, high-quality research and research-based po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enabling Sustainable Irrigation through Hydro-Powered Pumps for Canals' to be submitted under Horizon 2020.

assistant: **Abstract**

In irrigation water cannot be decoupled from energy. Raising water from rivers and canals and distribute it to the crops requires pumping of large volumes of water with a sizeable amount of pressure, which is generated by means of electric energy or by fuel-driven pumps. This turns into a substantial increase of energy consumption and capital expenditure, which has become a real concern for farmers and their communities. Besides, sharp increases in energy tariffs almost doubled the energy bills that irrigators have to pay, which accounts for up to 40% of the total irrigation costs for farmers’ communities. In a context exacerbated by the ongoing climate change, European farmers are striving to reduce their water footprint by means of water saving irrigation technologies while optimising their energy costs for pumping, with the aim to ensure long- term economic and environmental sustainability. To address this global need, aQysta has designed the HyPump, an innovative spiral pump which converts the energy from the flow of existing irrigation canals to pressure for pumping water, delivering pressurized water directly to the agriculture plots without requiring any fuel nor electricity to be operated. This Phase 2 is focussed on the industrialisation and field tests of the HyPump, which will allow farmers obtaining up to 75% savings on the overall costs for modernizing infrastructures and running an irrigation system with respect to competing electric or fuel-driven solutions, and up to 37% savings with respect to solar pumps. Through the Cost Benefit Analysis run during Phase 1, annual net savings have been estimated in the range of 5k€-8k€ per hectare with respect to electric pumping. Besides, a payback time in the range of 2,5-4 years has been estimated when switching fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Development of Benign Metal Alkoxide Initiators for Stereoselective Synthesis of Polyesters for Application as Scaffolds in Tissue Engineering'.

assistant: **Concept**

During the last years an intense research has been done in pursuit of the development of highly active and stereoselective initiators for the ring opening polymerization of cyclic esters such as rac-lactide, e-caprolactone, etc. However, there is still a need to develop a new generation of catalyst which shows higher activities and stereoselectivity. Furthermore, one of the most important applications of these polyesters is for biomedical applications, and therefore the need of “benign” initiators is also very high, if the final polymer is intended to be used for these purposes. Thus, in the initial part of this project we will synthesized a new range of metal alkoxide initiators for the polymerization of cyclic esters, which will allow us to obtain a library of polyesters of varying properties by fine tuning the ligands in the first coordination sphere of the metal centers of the initiator. We will focus on the molecular weights, polydispersity, stereochemistry (i.e. atactic, stereotactic or isotactic), composition, block-lenghts, etc. of the new polymers in view of its posterior applications. Thus, in the second part of this project we will prepare new scaffolds for Tissue Engineering, based on the library of polymers previously synthesized. In this part of the project we will fabricate flat sheets and hollow fibers with the different polyesters and evaluate its applicability in cell culture (both attachment and proliferation) in order to improve the current scaffolds based in the commercial polymers. Apart from these research objectives, this proposal is expected that will help the applicant to reach a position of professional maturity by gain experience in the area of controlled polymerization, scaffold fabrication. Also is expected for the applicant a development o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Crosstalk between microRNAs and epigenetics in melanocyte differentiation: A new approach to unravel the complexity of melanoma progression and metastasis' (EPIMIRMEL).

assistant: **Concept**

Melanoma is the most aggressive form of skin cancer and one of the most invasive tumor types. Melanoma incidence keeps increasing worldwide and the therapeutic choices are limited. The lack of treatments with durable responses may be due, at least in part, to an incomplete understanding of the molecular mechanisms that regulate tumor initiation and/or progression to metastasis. Therefore, there is an urgent need to find new strategies to expand our knowledge of melanomagenesis.We propose a new approach to unravel the complexity of melanoma: To use a cellular differentiation model to decipher the role of epigenetic regulation during melanocyte differentiation and its contribution to melanoma progression. Melanoma cells often express developmental genes, display multi-differentiation potential, and seem to recapitulate the migratory nature of neural crest stem cells from which melanocytes arise. We reasoned that studying a model of differentiation of melanocytes from neural crest stem cells could be useful to identify the mechanisms that modulate melanoma stem-like properties, probably among the most significant contributing features to the tumor aggressiveness. The plasticity and reversibility of the epigenetic mechanisms make them ideal orchestrators of these dynamic processes. Then, we hypothesize that epigenetically controlled miRNAs could be involved in normal differentiation and in tumorigenesis when altered. Thus, aberrant epigenetic modifications could be responsible for reactivation (or retention) of stem-like properties in melanoma cells. The identification of epigenetically regulated miRNAs involved in melanoma progression will be useful not only as prognosis biomarkers in order to stratify patients for more rigorous follow-up and aggressive therapy, but also b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synthetic biology for microbial lipids production from lignocellulosic biomass using multi-functional synthetic consortia' (SynBioLipid).

assistant: **Concept**

Global transition towards a climate-neutral economy demands for the sustainable use of renewable biological resources. Microbial lipids are potential products of bio-based industries and sustainable alternatives to petroleum-derived fuels and chemicals. The commercial development of microbial lipids from inexpensive feedstocks such as lignocellulosic biomass is so far limited mainly due to the elevated production costs imposed by physicochemical pre-treatments and extraction of intracellular lipids. In addition, degradation of lignocellulose releases compounds which are toxic for most of the microorganisms. One solution is to construct engineered organisms with improved metabolic capabilities integrating pre-treatment, fermentation, detoxification and secretion of lipids. Hitherto, there is no successful research on an engineered organism which is able to do all these tasks. In fact, efficient transferring large heterologous pathways into one single microorganism is quite challenging and leads to high metabolic burden and less productivity. SynBioLipid will combine my expertise in metabolic modelling and fermentation using mixed microbial communities with the host experience in synthetic biology. It is aimed at using Yarrowia lipolytica, as a model microorganism for microbial lipids production from lignocellulosic biomass by presenting an innovative and original strategy to overcome the challenges associated with expression of large heterologous pathways. I first will generate synthetic microbial consortia comprised specialist strains, and second, will use these communities for the optimized production of microbial lipids. Each specialist strain is engineered to deliver an optimum output for one or more specific tasks. The metabolic network modelling will be integrated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ecoval - internet platform for environmental assessment and trends' in the context of a Fifth Framework call.

assistant: **Objectives**

To date, environmental projects have tended to focus on the role that industry and big business plays with regards to pollution. However, there is a complete dearth of accessible information on the impact that the individual citizen has on the environment as a global system. While many people are conscious of environmental issues, they have no means by which to judge their overall impact on the environment. To this end, ECOVAL fills a vital gap in the environmental knowledge base through the innovative development of an internet platform that enables individuals to assess the impact of their lifestyle on the environment. Through primary data collection, based on self-completed questionnaires, Coeval's internet platform will build a database of individuals' CO2 emissions which, in turn, will provide a tool for cross-regional and European-wide comparison. Ultimately, the platform will enable EU decision makers to adapt their environmental policies to their local population.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Passive cooling solution validation for aircraft application' (HTCS) targeting Seventh Framework.

assistant: **Abstract**

The proposed project is part of the Cleansky activities for the “More electric” aircrafts.Such aircrafts require more power electronics integration and so “traditional” cooling systems (natural or forced convection, liquid loops,…) may reach their maximal performances because of the too high thermal dissipation density of these components. A need of heat spreading is clearly identified by the users.In this way, two-phase fluid capillary pumped heat transfer systems appear as more efficient alternative solutions thanks to their high heat transport capacity and their passive pumping capacity.Several passive cooling systems can be considered for these applications such as vapour chambers, heat pipes, high temperature loop heat pipes,…Such systems have background on space systems and environments; however, the demonstration of their functioning in avionic application, by modeling and experimental tests, is required before being equipped on an airplane.The EHP proposal will address the development, design, manufacturing and demonstration in a relevant environment - TRL6 (technology Readiness Level) - of a two-phase passive cooling system to be used on aeronautical applications.The size of equipment to be cooled is close to an A4 format.One hundred of watts are dissipated over several localized areas with a heat flux density around 30W/cm².The equipment is located in a harsh environment characterized by an ambient temperature of160°C and a low heat exchange coefficient. Despite these conditions, the equipment maximal temperature should not exceed 200°C.The EHP activities will consist in the following points:- Bibliographic review- Technology selection- Fluid selection- Cooling system sizing / modeling- Prototype construction- Experimental validation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A treatment for BRAF inhibitor resistant melanoma' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Some 50% of human melanoma tumors have activating mutations in the BRAF gene. BRAF inhibitor drugs given either alone or in combination with MEK inhibitors have improved progression-free and overall survival in patients with BRAF mutant metastatic melanoma. However, drug resistance invariably limits the duration of clinical benefit of such treatments and is almost always associated with re-activation of signaling through the MAP kinase pathway in the presence of drug due to secondary mutations in the pathway. This highlights the urgent need to develop strategies to treat melanomas that have developed resistance to BRAF and/or MEK inhibitors. As part of an ERC advanced grant, my laboratory has shown that BRAF inhibitor withdrawal in melanomas that have developed resistance to BRAF inhibitors leads to a transient growth arrest that is the consequence of temporary hyperactivation of signaling through the MAP kinase pathway, explaining the so called “drug holiday effect”. We have also found that subsequent treatment of such BRAF inhibitor resistant melanomas with Histone DeACetylase inhibitor drugs (HDACi) leads to persistent hyperactivation of MAP kinase signaling, causing both chronic proliferation arrest and cell death, ultimately leading to complete regression of BRAF-inhibitor resistant melanomas in mice. We propose here to perform a proof of concept study in at least 10 evaluable melanoma patients that, after proven initial tumor response, have developed resistance to BRAF inhibitors to validate that subsequent treatment of such patients with an HDACi drug will result in durable responses. Translational studies on tumor biopsies taken before, during and after HDACi treatment will be performed to study the cellular effects of HDACi treatment. Our goal is to provide ini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electron Holography of magnetic and ferroelectric Nanoparticles arrays' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Electron Holography is attracting increasing interest as a method of material characterization by using Transmission Electron Microscopy (TEM), because it has various applications. These applications include: evaluation of magnetic and ferro-electric domains, imaging of the 3D shape of nano-structures, and dopant profiling in semiconductors.The required attachment for electron holography was introduced into our TEM and our first steps were obtained with the cooperation of Prof. Lichte from Dresden University, a leader of the field. In this TOK (Transfer of Knowledge) program we intend to establish the method at Tel Aviv University by studying arrays of magnetic and ferroelectric nano particles. Such unique samples prepared by Dr. Gil Markovich from the School of Chemistry are of interest for both reasons:- In the field of nanoscale ferromagnetic and ferroelectric materials there is a need for a technique that will be able to image the magnetization or electric polarization with nanoscale resolution. Electron holography has this capability and has many advantages over competitor techniques such as scanning probe microscopies. Together with temperature control of the sample, it would be an excellent tool to follow the dynamics of magnetization/electric polarization switching on the time scales of seconds or longer, and thus unprecedented information about the magnetic/electric dipole configurations in thin films of ferromagnetic/ferroelectric nanocrystalline arrays will be obtained.- Due to the nanometer scale of the systems, they represent a challenge, as the electron holography method should be pushed to its limiting capability of detection. While the majority of the work will be carried out at Tel Aviv University, by European post doctorate fellowships with relevant ba