RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ancient DNA and the Atlantic Slave Trade: A Search for Origins' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project aims to use ancient DNA (aDNA) analyses to trace the geographical origins of African slaves who were brought to the Caribbean as a result of the trans-Atlantic slave trade. Between the 15th and 19th centuries, the trans-Atlantic slave trade resulted in the forced migration of over eleven million Africans to the Americas. In recent years, there has been growing interest among scholars, as well as the general public, in restoring knowledge of their origins. Historical documents provide obvious sources of information but their usefulness is restricted by the fact that they generally refer to the coastal areas from where slaves were shipped, rather than where they actually originated. Recently, geneticists have tried to tackle the question of origins from a different angle, using modern genetic data. The phylogeographic perspective has revealed that it is possible to use the inheritance characteristics of the non-recombining mitochondrial DNA (mtDNA) molecule to trace the maternal ancestry of individuals to specific geographical regions within Africa and, in some cases, even to particular ethnic groups. However, there is a problem with this approach. Although only about 200 years have passed since the abolition of the slave trade, there has been considerable population movement to and within the Americas, so that modern genetic distributions may not accurately reflect the effects of the trans-Atlantic slave trade. This is where this project comes in. Ancient DNA analyses on archaeological skeletal remains provide a window back in time, so to speak, that enables us to test hypotheses based on modern data. We propose to use aDNA analyses of human remains from several archaeological sites in the Caribbean to reconstruct the ancestral relationships of African slave
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A Network Science Approach to Social Cohesion in European Societies'.

assistant: **Concept**

As European societies are becoming increasingly unequal, diverse, and polarised, concerns about their cohesion are growing. In this light, it is surprising that social cohesion research has almost entirely ignored one of its core dimensions: relationships. Broad acquaintanceship networks, which connect each individual to hundreds of others through both intimate and superficial relationships, have long been assumed to bind societies together and provide a sense of community and solidarity. Nonetheless, they have hardly been studied empirically due to the technical complexity that the comprehensive study of society-wide networks involves. This project will develop a ground-breaking, network-scientific approach to social cohesion. After designing a theoretical framework for the structural cohesion of societies, it develops a new methodology to study structural cohesion empirically, hybridising two strands of network research in an unprecedented way. The methodology will be implemented in a large-scale, cross-national European survey administered to representative samples of the populations. The survey estimates are used to simulate society-wide networks, to explore resulting macro-level structures. These macro-level structures are then used to specify agent-based models to study in more depth how broad acquaintanceship networks influence subjective manifestations of cohesion. For the first time, we will know how cohesive broad acquaintanceship networks are across categorical fault lines of citizenship, social class, religion and political orientation for five societies, how real-life inter- and intragroup relationships cluster to form network constellations that expose individuals in unique ways to other social groups, and how these constellations shape subjective manifest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modelling of the reliability and degradation of next generation nanoelectronic devices' under Seventh Framework.

assistant: **Concept**

In this project we will develop multiscale modelling technology supported by comprehensive experimental characterization techniques to study the degradation and reliability of next generation Complimentary-Metal-Oxide-Semiconductor (CMOS) devices. Building upon fundamental analysis of the structure and electronic properties of relevant materials and interfaces at the quantum mechanical level, we will construct mesoscale models to account for defect generation and impact on CMOS transistor and circuit performance and yield. The models will provide detailed understanding of the common reliability issues and degradation routes, and will be verified by cutting edge experimental characterization. Strong links with industry insures that the project will make a step change in the process of next generation device modelling and design. The project will provide technologists, device engineers and designers in the nano CMOS industry with tools, reference databases and examples of how to produce next generation devices that are economical, efficient, and meet performance, reliability and degradation standards.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Neuronal circuits controlling fear behavior' (NEUROFEAR).

assistant: **Innovation**

Accurate adaptation to stimuli predicting threatening outcome is critical to survival. An insufficient fear reaction may lead the animal to overlook future signs of danger, whereas overreacting may lead the animal to failure to explore and miss opportunities for feeding or mating. Numerous data indicate that the medial prefrontal cortex (mPFC) plays a key role in the control of fear behavior and that distinct prefrontal areas differentially regulate the expression/inhibition of fear responses. Whereas lesions/inactivations of the mPFC infralimbic (IL) area promote fear expression, lesions/inactivations of the mPFC prelimbic area (PL) promote fear inhibition. Moreover, PL and IL receive segregated inputs from functionally distinct amygdala circuits activated during high and low fear states. These data suggest that a key function of mPFC circuits might be to integrate inputs from the amygdala to ultimately gate fear expression via projections to specific neuronal circuits. However, little is known about the underlying neuronal circuits. Is the rapid switch between expression/suppression of fear behaviors mediated by the same circuits or does the mPFC contain distinct circuits dedicated to the control of opposite behaviors? Is there an organization in terms of afferents and efferent at the level of mPFC neuronal circuits? To address these questions we will use a cross-level approach combining in vivo electrophysiological optogenetic and behavioral approaches to elucidate the anatomical/physiological properties of mPFC circuits and to address their functional role in the control of fear behavior. We will first examine the activation and connectivity of mPFC circuits using in vivo extracellular recordings and extracellular stimulations. We will next selectively manipulate th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of structural genomic variants in eco-evolutionary processes' (EVOL-SV) targeting Horizon Europe.

assistant: **Abstract**

Genetic diversity is a fundamental level of biodiversity at a time of global change. It provides variation that underpins species persistence and their adaptation to changing environments. Variation in the direction or presence of DNA sequences has been largely overlooked until now. Yet, those structural variants (SVs) represent a key aspect of genetic diversity. SVs cover 3 to 10 times more of the genome than the well-studied single-nucleotide variants and have different properties (length, effect on recombination, mutation rate). Structural variation thus represents a quantitative and qualitative shift in our understanding of genetic diversity, with predicted, but understudied, implications for evolution.The project EVOL-SV calls for a reassessment of the genomic basis of eco-evolutionary processes. My ambition is to lead new research avenues on the impact of SVs in ecology and evolution and to determine the contribution of SVs to current biodiversity. I will combine cutting-edge genomics and powerful experimental approaches, developed throughout my career, to perform multidisciplinary research on a focal system, Coelopa flies, and then across taxa.First, I will investigate SVs within a population genetic framework in Coelopa spp. to determine how SV properties affect their distribution and effects on fitness. Second, I will assess the contribution of SVs to deleterious load in a case of range shift northwards. Third, I will examine how SVs contribute to phenotypic adaptation, focusing on parallel climatic gradients and rapid thermal variation. Fourth, at a broader phylogenetic level, I will draw general principles about the evolution of structural genetic diversity.EVOL-SV will have long-term impacts by providing the first comprehensive assessment of structural genet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Transmission over Channels with Insertions and Deletions' in the context of a Horizon Europe call.

assistant: **Objectives**

Insertions and deletions represent perhaps the most challenging impairments exhibited by communication channels in a wide range of applications from recording systems and covert communications to DNA storage. While tremendous progress has been made in determining the ultimate limits of communication using information-theoretic tools as well as in designing and implementing signaling solutions for various channel models with practical significance; for the case of insertion/deletion channels, even the simple scenarios are not fully understood. For instance, we do even not know the capacity of the basic independent and identically distributed binary deletion channel. TRANCIDS will take on the monumental challenge of conquering the insertions and deletions by developing precise theoretical limits of communication and by designing explicit and implementable coding solutions approaching these limits. Specifically, TRANCIDS will 1) establish with precision the capacity of basic deletion/insertion channels, and obtain tight upper and lower bounds on the capacities of more sophisticated channel models encountered in practice (including the effects of noise and interference); 2) formulate and explore wireless communication problems with insertions and deletions (including multi-input and multi-output systems as well as different multi-user communications settings); 3) develop explicit and implementable channel coding solutions for a variety of channel models with insertions and deletions of practical importance; 4) address the channel capacity and code design problems for channels with additional impairments such as permutations as motivated by in-vivo DNA storage applications. TRANCIDS will highly impact different emerging applications such as DNA storage and beyond 5G wireless
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'THE POTENTIAL OF RESEARCH DATA – HOW RESEARCH INFRASTRUCTURES PROVIDE NEW OPPORTUNITIES AND BENEFITS FOR SOCIETY HIGH-LEVEL PRESIDENCY CONFERENCE ON RESEARCH INFRASTRUCTURES'.

assistant: **Objectives**

Europe has one of the most advanced and integrated research infrastructure systems in the world. During the last years, Europe has invested large sums in research infrastructures, i.e., state-of-the-art experimental facilities to reinforce Europe’s research and innovation system by providing research communities with unique expertise, instruments, technical resources, data, and services. This facilitates the performance of cutting-edge basic and applied research, boosting of technological advancements and breakthrough innovations. They also bring benefits to industries and SME’s. Research infrastructures provide knowledge-based solutions to societal challenges and aids in the delivery of the EU’s green and digital transitions. Research infrastructures is a top priority for the current trio of French, Czech, and the Swedish presidencies of the European Council. The objectives of the Swedish presidency conference on research infrastructures are:•Making research infrastructures more visible by directing towards the capabilities of reusable and open data for research and societal benefits sensu lato.•Identifying challenges and means to face them by increased collaboration between sectors and stakeholders.•Accelerating the creation of values from research infrastructures by further developing and strengthening the work with reusable and open data for producers and consumers.The conference is arranged in Lund, a high impact research and research infrastructure hub, bringing together 250 people from a range of sectors from different levels that benefit from research infrastructures and open data and science to discuss relevant topics. The values foreseen after the conference are further strengthening of research infrastructures and facilitation of broader success to them, aid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Alpha1H: A Unique Bladder Cancer Therapeutic, Acting with Great Precision'.

assistant: **Objectives**

Novel cancer treatments should ideally combine efficacy with selectivity. Tissue toxicity and side-effects are still the norm, however. Although new targeted therapies act with greater precision, the notion of tumour-specific cell death is justly regarded with scepticism. The Swedish company Hamlet Pharma provides new cancer treatments based on a peptide-based molecular approach for targeting and killing tumour cells with greater precision. Its proprietary drug complex, HAMLET (‘Human Alpha-lactalbumin Made LEthal to Tumour cells’) is derived from the human breast milk protein, alpha-lactalbumin, and represents a ground-breaking therapeutic solution with high tumour-killing capacity, high target specificity, killing >40 different types of tumour cells and no demonstrated toxicity. As such, it has the potential to revolutionize cancer treatment. Hamlet Pharma is now advancing HAMLET and the synthetic drug candidate Alpha1H along the clinical development pipeline as anti-cancer therapeutic for early stage bladder cancer. The company is focusing on bladder cancer given the high clinical need for more effective and safe treatment options. Bladder cancer has the highest recurrence rates (70%) and treatment costs per patient among all cancer types (total costs in Europe: >€4.9 billion). Recent successful outcomes include initial Phase I/II clinical trial data, proving that Alpha1H acts with high efficacy without any detectable toxicity. With the EIC Accelerator funding, Hamlet Pharma will finalise Phase I/II clinical safety and efficacy studies and advance development of Alpha1H towards a Phase III trial (i.e. ready for licensing deal or IPO). Conversations with potential licensing partners and investors are ongoing. Alpha1H will be an important showcase of the impact HAMLET
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Underground power cables remote monitoring by a smart control system based on a novel optical sensor platform' (CableSENS), addressing dissemination and exploitation.

assistant: **Impact**

More and more Electricity System Operators (ESOs) are required to bury larger number of sections of the power grid mainly because security, visual and environmental impact concerns. However, such underground sections have a negative impact on the overall power supply efficiency, quality and security, resulting in severe economic losses and reduction in reliability of the grid. Besides, underground sections are more difficult and expensive to install, operate and maintain. In addition to the economic impact on the ESOs, underground faults also have a negative impact on society directly depending on the blackout time (time between breakdown and restoring) of the line. The development of the future Smart Power Grids requires an improvement in efficiency and security, through the implementation of new technological solutions that in addition will allow reducing operation and maintenance (O&M) costs incurred by the ESOs.Lumiker, a European R&D SME developing disruptive solutions for the power industry, has detected a market opportunity in such sector: ESOs lack smart solutions providing remote and real time information regarding: i) the condition of the underground sections (damage); ii) discrimination of faults (overhead or underground) and iii) rapid localization of underground faults. Such solutions will allow to reduce both the outage time of the power grid and associated costs, especially for the underground sections.  Improved control of the underground sections of the power grid could help ESOs to reduce up to 76% of O&M associated costs in such underground sections.Lumiker will take advantage of this business and market opportunity by introducing into the market the CableSENS system, a novel application based on Lumiker’s patented optical sensor platform adapted for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Green technology for fresh water sea-transportation based on a flexible containers system' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

50 million European citizens, 18% of the European population, live in countries affected by water stress problems; forecast variations in rainfall pattern trends, due to global climate change, add to this already serious situation: according to the EEA, 16 to 44 million additional people will suffer water scarcity in Southern Europe by 2070.  The importance of the problem is recognised at the European level, as proven by the strong common European position at the recent Fifth World Water Forum (March 2009) and by the 2007 Communication of the European Commission, urging the Parliament and national governments to do more regarding water scarcity issues.  Current water supply systems (water pipelines, desalination plants, tank vessels) require permanent infrastructures, high investment costs, high energy consumption, with maintenance issues that could not be easily addressed by small-medium communities and for temporary water supply.REFRESH aims at realising an innovative green product/service for the transportation of fresh water by sea, by developing a cost effective and energy-efficient solution based on the use of a modular concept of recyclable flexible plastic barge towed by tugboats.  The primary application will be in supplying fresh-water to Mediterranean coastal small cities and islands with less than 300.000 inhabitants (a situation which interests about 45 million of European citizens). 65% of these communities, that double in size during summer with tourist presences, are affected by increasing water scarcity due to several factors as climate change, growing urbanisation of coasts, tourism, sea water intrusion in aquifers. For these communities REFRESH will represent the most effective solution for fresh-water supply since traditional technologies as water pi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Simulation scenarios for potential radioactive spreading in the 21st century from rivers and external sources in the russian arctic coastal zone' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The Project goal is to perform simulation scenarios for the 21st century, including global warming scenarios, of potential radioactive spreading from sources in the Russian Arctic coastal zone and its impact on Barents, Greenland and Norwegian Seas and the Arctic Ocean. Extensive environmental and pollution data sets will be collected and will provide update for the AMAP database. Datasets will be used for numerical simulations using a Generic Model System, consisting of several nested and integrated models. Simulation studies will be done for the selected release" scenarios using various atmospheric forcing scenarios for the 21st century, including global warming, likely consistent with a CO2 doubling. The project results will be used for assessment of the impact on potential radioactive spreading from selected sources as input to a radioactive risk management and decision-making system."