RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative modular brake concepts for the integrated European high-speed railway system' (MODBRAKE).

assistant: **Concept**

MODBRAKE aims at contributing to the practical implementation of interoperability of railway systems across Europe by addressing brake system performance. The project follows the vision and approach of the Integrated Project MODTRAIN, which started in February 2004. The braking system is one of the most critical and complex subsystems of rail vehicles, in particular in relation to safety requirements. Current situation in brake supply sector is characterised by the unnecessary and costly diversity of brake systems design, testing, validation and maintenance procedures. To reduce this complexity and therefore the costs of the brake systems the project proposes modularisation of the brake system. The related system specifications will be elaborated, evaluated and tested to develop a modular brake concept. The standardised modules will be interchangeable in terms of functions and interfaces while they may still be specific to each manufacturer so as to guarantee future technological progress.  The main outputs o f the project will be: -Specification of the modules (according to all relevant levels of the rolling stock architecture) of the brake system -Design of the modules and their interfaces -Specification of assessment and maintenance processes (especially ins pection/test criteria for safety and reliability) -Development/improvement of a tool for the evaluation of the life-cycle-costs of brake modules -Realisation and practical tests of prototypes -Direct proposals to standardisation bodies about future brake requirements to be standardised or standards to be enhanced.  The main stakeholders in the high-speed railway sector (the 2 major European brake suppliers; the 4 major European system integrators; 3 railway operators; 2 industrial associations) assisted by 3 rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'New positive tone resist for deep x-ray lithography based on the concept of chemical amplification'.

assistant: **Objectives**

Research objectives and content The goal of this project is the development of a new positive tone resist for deep X- ray lithography (DXRL) with high sensitivity. The standard resist material for deep X- ray lithography is poly(methyl methacrylate) (PMMA) which is very suitable, since structures with a high resolution can be obtained. A disadvantage, however, is the low sensitivity of PMMA which demands long irradiation times and leads, therefore, to a relatively expensive process. In order to obtain a resist with high sensitivity, the principle of chemical amplification should be used. This concept has been described for photolithography by Ito and Willson, applied for X-ray lithography by Dammel, and used in the field of DXRL by Schenk for the development of a negative tone resist. In this proposal two concepts for the development of positive tone resist systems for DXRL are described in detail. These resist systems containing two or three components, a polymer matrix, an acid generator, and in one case an additional crosslinker. Upon irradiation the acid generator is releasing a proton which leads to a series of chemical reactions resulting in a increased solubiltiy of the irradiated regions. For both concepts it is absolutely necessary that the different resist components have to be optimized for the DXRL process. Training content (objective, benefit and impact) The postdoctoral work includes the tasks synthesis and characterization of polymers and further resist components and investigation of the acid catalyzed cleavage of the new polymers and polymer networks. Furthermore, the resist films have to be prepared, irradiated and the resulting microstructures have to be analyzed. A successful work in the field of DXRL needs the application of different techniques and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Chiral Triamino Iminophosphorane Organocatalysts and their Reactions' (CHIRALTIPOCAT), addressing dissemination and exploitation.

assistant: **Impact**

We wish to develop new families of chiral single enantiomer triamino iminophosphorane bases and exploit their high basicity in a series of new organocatalytic asymmetric methodologies for providing ready access to desirable chiral products with high enantio- and diastereocontrol from readily available starting materials. This would constitute a new, powerful and broadly applicable organocatalytic asymmetric strategy to such target molecules. The development of new readily accessible and modular designs for tunable single enantiomer triamino iminophosphorane bases will be carried out via two complementary routes that could allow the synthesis of focused libraries of tens of catalysts for screening in a range of important synthetic transformations. In the first, stereochemically pure azides are heated with phosphorous triamides, which upon release of nitrogen yields the target base in just one simple transformation. As azides can be readily prepared from parent enantiopure alcohols via Mitsunobu inversion or from amines through diazo transfer, the route benefits from a broad-based simple design which can allow much structural variation to the target triamino iminophosphorane bases. An alternate route would employ commercially available or readily prepared chiral ethylene diamines reacting with PCl5 followed by triple N-alkylation. The performance of these new highly basic chiral organocatalysts will then be assessed in a range of addition reactions of methylene and methine pronucleophiles to a range of low reactivity electrophiles. Furthermore, through molecular modelling we would like to elucidate the mechanistic pathway and origins of stereocontrol and finally apply the chemistry in the total asymmetric synthesis of the natural product (R,R)-elacomine. The work will the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Morphotectonic Map of European Lowland Area'.

assistant: **Innovation**

This project is concentrated on creating a new research team in the Polish Geological Institute that will be concentrated on evaluation of the innovative methodology for Morphotectonic Map of the European Lowland Area compilation. The team to be created will derive its knowledge from the experiences of best European research groups in the field concerned.The synergy resulting from the joining of best European practices will make it possible to create the new quality in monitoring of large natural areas using multidisciplinary (paleogeographic, geostructural, tectonic, hydrogeological, geophysical) methods. After implementation of this project the PGI will co-ordinate the efforts on the map compilation.The team is going to concentrate on the following problems, which have never been a subject of survey before:- the influence of tectonic structures of different order in connection with multiphase flow of liquid in orogen on glacial process in Pleistocene,- correlation of tele-detective and proximate methods as a tool of determining zones of peculiar frequent structural disturbances and testing its influence on the process of the hydrodynamic field formation and the mass movements in glacitectonic and neotectonic young-alpine structures,- verification of the absolute dating methods of nuclear physics in natural environment condition survey,- evaluation of the world new method of oil and gas deposits exploration.The Morphotectonic Map of the European Lowland Area will show the activity of deep structures in connection with active surface and subsurface processes. Recognition of these processes, their exact timing and dating will contribute to the recognition of the natural environment and will enable to prepare the first forecasts of changes in human habitat.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Using sponges as a model to examine the evolution of the Wnt/beta-catenin signaling pathway' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The central concept of the field of evolutionary developmental biology (evo-devo) is that changes in development give rise to changes in form. While recent advances in both comparative genomics and experimental biology have greatly accelerated the rate of discovery in evo-devo by facilitating the study of non-traditional experimental models, we have only begun to understand how developmental mechanisms themselves first evolved, and how these ancient evolutionary events shaped the morphological evolution of lineages that persists today. The focus of this proposal is on the evolution of the Wnt/beta-catenin developmental signaling pathway and its role in modern sponges, one of the earliest branching metazoan lineages. In bilaterians, the Wnt/beta-catenin pathway plays a critical role during animal development, as it controls cell differentiation, proliferation and apoptosis by regulating the expression of a high number of target genes. In addition to its normal functions, misregulation of this pathway can lead to serious diseases in humans, such as cancer. The discovery of conserved homologs of the Wnt/beta-catenin pathway in sponges raises questions about whether a functional Wnt/beta-catenin pathway is present in sponges and what its role may be in organisms of such simplicity – they lack many features of bilaterians, such as muscles, nerves and a gut. The specific aims of this study are to (1) test whether the sponge homologs of Wnt/beta-catenin components interact (2) identify the tissue-specific and subcellular localization patterns of beta-catenin and TCF (these proteins form the transcriptional complex downstream of the Wnt/beta-catenin pathway) (3) identify which target genes are regulated by the beta-catenin/TCF transcriptional complex and (4) develop techniques
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Suicide Bomber Counteraction and Prevention'.

assistant: **Concept**

SUBCOP sets out to develop technologies and procedures that can be applied by the Police Security Forces when responding to a suspected PBIED (Person Borne Improvised Explosive Device). It addresses the course of action to take when an alert to a possible PBIED has been issued, and an attack may be imminent. SuBCoP is insensitive to how the alert is raised, should it be based on detection of explosives or explosive devices, informants’ reporting, or other intelligence sources. It is however sensitive to the fact that the alert only gives cause for suspecting the presence of a PBIED, and that this suspicion can be of lower or higher confidence. SUBCOP will develop guidance as to what response to a PBIED that is ethically and socially justifiable for a given situation. The core objective of SUBCOP is to consider•the available technological tools for less than lethal PBIED intervention,•the novel procedures for their application, and•the development of new less than lethal capabilitiesThese together will fit to the highly set requirements; to avoid injuries on the suspect yet control the situation to such an extent that no harm will come to innocent bystanders or first responders, should the suspicion of a PBIED presence be accurate. The SUBCOP consortium is well equipped to address this complex and challenging task, encompassing small scale and large scale security focused and technology developing enterprises, security and defence research organisations, medical and ethical expert organisations and end users with first hand experience in PBIED situations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The molecular basis of post-initiation regulation of RNA transcription' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Since RNA transcription is an important early step in the process of gene expression, it is tightly regulated at all its constituent phases.  These include initiation of transcription, elongation and termination of the process at the end of the gene or operon.  Post-initiation regulation of RNA transcription during the elongation phase by the alternative pathways of termination, pausing or elongation allows the cell or organism subtle control over the expression of genes that are constitutively expressed or produced in response to environmental signals.  Pausing is a central event in this type of regulation, halting the elongation complex at pause or termination sites, allowing regulation or termination events to occur.  These signals can be modulated by protein and RNA transcription cofactors, examples of which have been found in bacteria, fungi and mammals.  It is the kinetic competition between the rates of these alternative pathways that are available to the elongation complex at pause or termination sites, which are modulated by transcription cofactors. This proposal aims to understand how these kinetic rates are altered by transcription cofactors using a novel surface plasmon resonance (Biacore) assay to study two bacterial antitermination systems.  In order for this to be possible, it is important to understand how these transcriptional cofactors localize to, and assemble on, the elongation complexes at these sites.  This project proposes to use various biophysical and biochemical methods to determine the structure of the protein cofactors and nascent RNA sequences upstream of the termination sites as well as the binding affinity and order of assembly of the protein co-factors on these sequences.  This information will be used to develop, and screen for, agents t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainable Environmentally-friendly Advanced-Composite Zero-Emission Boats' to be submitted under Horizon 2020.

assistant: **Abstract**

The SEABOAT concept will tackle inherent issues in the recreational boat manufacturing industry, with a particular focus on addressing outdated, inefficient, costly and environmentally inferior hull-manufacturing processes that will not meet new legislation. It will also address the demand by recreational boat users for improved performance and sustainability advantages, comparable to those delivered by electric cars. In response, SEABOAT will deliver significant positive impacts in terms of industry/EU competitiveness, scalable company growth in revenue & jobs, and a wide array of performance & environmental benefits. This will be achieved by commercialisation of the Composite Powder Epoxy Technology (C-PET) manufacturing process within the recreational boat manufacturing segment and by introducing a revolutionary E-Boat design incorporating the C-PET manufactured hull into the market, enabling ÉireComposites (composites manufacturing technology expert) to achieve in excess of €45m cumulative revenue and 260 jobs from 2021-2023. Originally conceived for aerospace/renewable energy applications, C-PET is a high-performing, cost-effective manufacturing technology that will lower the cost of boat hulls by 30%, eliminate toxic Volatile Organic Compounds & reduce hull weight by 45%. Reduced hull weight will allow extra batteries and enhance boat range/performance, so that for the 1st time ever, battery-powered boats will be able to compete with fuel-powered alternatives. C-PET will be demonstrated & tested in an advanced electric boat, reducing operational costs by 60% & delivering 0 emissions, with tangible benefits along the whole life-cycle. SEABOAT will enable wider adaptation of electrical boats (replacing fuel powered engines), helping drive growth in the market for el
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Archaeology of the Light: multiproxy, interdisciplinary and experimental approach to the knowledge of palaeolithic subterranean activities' in the context of a Horizon Europe call.

assistant: **Objectives**

The control of fire is a milestone in human evolution. Artificial lighting is a crucial resource for the expansion of social and economic behaviour in Palaeolithic groups beyond the day hours. Besides, this allowed the potential development of the first symbolic comportment located in deep caves probably at least 176ky ago. This would increase during the Upper Palaeolithic when archaeological remains proliferate in darkness linked to the rock art. The A-LIGHT project, Archaeology of the Light, aims to improve our knowledge of palaeolithic activities in caves through a pioneering and interdisciplinary methodology applied to rarely-studied remains: the residues of Palaeolithic light. Its multi-analytical approach will provide multifaceted information, including the widely debated chronology of the first cave art. Additionally, it will supply useful data for other researchers who delve into topics related to cave art and the symbolic world of the Palaeolithic (visibility, accessibility, space perception...). The experimental reproduction will permit evaluating the efficiency of the light systems deduced from the previous multi-analytical study and reach a Virtual Scientific Reproduction (prototype in non-academic placement), with its economic potential in heritage dissemination and tourism activities. It also includes an ethnographic section which will help shedding some light on alternative interpretations to the utilitarian aspect of the firelight. The host institution (UBx), under the supervision of Dr. Ferrier, will conduct and train Dr. Medina, a specialist in Subterranean Archaeology from Spain, to advance her training in Archaeo-pyrotechnology in caves (multiproxy, multi-analytical and experimental approach, with special incidence about on-site analysis). Dr. Medina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unfolding the early Htt aggregates: an interdisciplinary approach for characterizing novel molecular events that impact Heat Shock Response in Huntington Disease' (UnfearHD), addressing dissemination and exploitation.

assistant: **Impact**

A common characteristic in many neurodegenerative diseases (NDs) is the presence of disordered proteins that form toxic aggregates. In Huntington’s disease (HD), expanded polyQ tracts on Huntingtin (Htt) lead to the formation of aggregates, which affects many cellular functions, eventually resulting in cell death. Heat Shock Response (HSR) is a protective mechanism that facilitates (among other functions) the clearance of protein aggregates. Paradoxically, HSR becomes impaired in HD. The fact that early Htt aggregates, prior to becoming severely aggregated or toxic, fail to trigger HSR indicates that this impairment likely occurs early in the HD pathogenesis. The molecular mechanism underlining the HSR impairment in HD remains elusive. The aim of UnFearHD is to unravel the mechanism that links Htt aggregation with HSR impairment in early stages of HD.Several lines of evidence indicate that disordered proteins, having the ability to phase separate, may directly regulate translation and transcription, as shown for biomolecular condensates. Our hypothesis is that aggregation-prone Htt alters the early HD proteome composition in a way that impacts the HSR, by directly interacting with RNA and DNA. To explore our hypothesis, we will employ C. elegans strains engineered for inducible Htt expression and combine unbiased omics to a) directly interrogate the Htt interactions with RNAs and DNAs, using a UV-based crosslinking and immunoprecipitation (CLIP) and b) understand the consequences of such interactions at proteome level, using a bioorthogonal non-canonical amino acid tagging (BONCAT). The UnfearHD project will enable the establishment, for the first time, of a direct association between Htt aggregation and HSR impairment, which is detrimental for HD progression. The findi