RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanisms of Gene Silencing by the Glucocorticoid Receptor' (SILENCE), addressing dissemination and exploitation.

assistant: **Impact**

I propose to decipher the unresolved molecular paradox of positive versus negative gene regulation by the Glucocorticoid Receptor (GR). GR is one of the most potent anti-inflammatory drug targets in clinical use today, and one of the most powerful metabolic regulators. Unfortunately, its unique ability to efficiently shut off inflammatory gene expression is accompanied by serious side effects. These undesired effects are attributed to the transcriptional activation of its metabolic target genes and limit its therapeutic use.SILENCE uses cutting-edge genome-wide approaches to identify the molecular mechanisms underlying the transcriptional repression, or silencing, of inflammatory genes by GR. The general, open question I want to address is how one transcription factor can simultaneously both activate and repress transcription.GR is a member of the nuclear hormone receptor family of ligand-gated transcription factors. Upon hormone binding, GR can regulate gene expression both positively and negatively, but the mechanism governing this choice is unknown. I have previously shown that classical models and existing paradigms are insufficient to explain GR-mediated gene silencing. Therefore, I postulate the existence of unknown coregulator proteins, cis-regulatory DNA sequences, noncoding RNAs, or combinations thereof. To test these hypotheses, I plan 1. a large scale RNAi screen to identify those cofactors that specify repression versus activation, 2. ChIP-exo experiments to map genomic GR binding sites at an unprecedented resolution, and 3. GRO-Seq studies to define the role of noncoding RNAs during the silencing of inflammatory genes.Inflammation is known to contribute to the pathogenesis of numerous human illnesses, including cancer, autoimmune diseases, diabetes and card
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ARTIFICIAL INTELLIGENCE SUPPORTED CONSULTANCY SYSTEM FOR FISH PROCESSING OPTIMIZATION' (VALKA).

assistant: **Concept**

Our world’s marine ecosystem is at the brink of collapse because of extensive fishing: 31% of fisheries are overfished and 58% are fished to their capacity. However, the reduction of fish quotas would entail the subsequent loss of job positions and fish industry profitability, leaving many countries within the European borders in a complicated position from a socio-political plane. Thus, to make global fishing sustainable, the industry needs to maximize the value of fish products to allow applying higher restrictions in the fish quotas without a socio-economic impacting. Valka was founded in 2003 as an Icelandic start-up with the vision of becoming the leading provider of fish processing systems globally. Since then, we have been growing by designing and producing high tech systems for fish processors with the aim to maximize accuracy, increase yields and efficiency through automation in collaboration with the customer. In this regard, FishPro plays a pivotal role in our internationalization process by paving the way for entering new markets though a disruptive value proposition which place us in the technological forefront of the sector. Hence, the multidisciplinary group of experts which constitutes the 80 members of the company have a fully commitment with the present project. To contribute to fisheries sustainability, we are developing reinforced learning based consultancy software (FishPro) to optimize the value of the whole load and match the raw material with the sales orders. FishPro software provides recommendations for optimal processing of the catch to maximize value. (e.g. market, type of fillets, conditioning). This will ensure optimal matching of the products with the demand, thereby minimizing waste. This manner, we have estimated a 25% improvement with r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a high resolution, low cost, short range precipitation radar system' (MARG), addressing dissemination and exploitation.

assistant: **Impact**

The MARG project addresses the need to increase the competitiveness of the SME partners by developing an accurate, real-time and user friendly measurement system for monitoring spatial distribution and intensity of rain in rural and urban scale. By providing the innovative system and the data acquired via the system to business that are directly impacted by rain consortium SMEs intend to capture a significant share of the weather market that is valued at € 200 billion only in Europe. SMEs that cover the supply chain want to take an advantage of early market penetration and outrun the competition. During the project a pre-competitive prototype will be crafted by partners for single radar and network application. Partner SMEs strongly believe that it will turn to a marketable product by 2014 and within the first 5 years of exploitation it will gain a total profit of € 1.5 M for them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Global immunopeptidome landscape of normal and Mycobacterium tuberculosis-infected human cells' (IMMUNOPEPTIDOMICS).

assistant: **Concept**

MHC class I-associated peptides are presented at the cell surface for scrutiny by CD8+ T lymphocytes and are collectively referred to as the immunopeptidome. The immunopeptidome plays crucial roles in many processes including autoimmunity, cancer immunosurveillance and elimination of pathogen-infected cells. Nevertheless, very little is known about the molecular composition and biogenesis of the immunopeptidome in health and disease. Through a multidisciplinary effort, I will conduct both fundamental and applied immunopeptidomic studies by using cutting-edge technologies in mass spectrometry(MS)-based proteomics. First, I will apply systems-level approaches to investigate the global relationship between the immunopeptidome, the proteome and the degradome in human cells under normal physiological conditions, i.e. in the absence of infection. This will allow us to gain new fundamental insights into the biogenesis of the immunopeptidome and will provide general concepts of how to manipulate MHC I peptide processing and presentation in immunity. Second, applied research will be conducted by mining the immunopeptidome of human cells infected by the life-threatening pathogen Mycobacterium tuberculosis (Mtb). Each year, almost two million people die of tuberculosis (TB) raising the urgent need of a new and more efficient vaccine against TB. In this project, we aim to discover numerous MHC I peptides encoded by Mtb proteins that could be further evaluated as vaccine candidates against TB. Altogether, the impact of this project on EU competitiveness will be enormous by accelerating the rational design of immunotherapeutic interventions against autoimmunity, cancers and infectious diseases, TB in particular.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Identifying genes involved in microRNA turnover in Arabidopsis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

MicroRNAs (miRNAs) are small non-coding RNA molecules regulating the expression of protein coding genes by targeting mRNAs. Since they play key roles in development and in responses to both biotic and abiotic stresses, it is important that miRNAs are expressed at the right time and place. Therefore there must be a mechanism to degrade miRNAs (miRNA turnover) and that mechanism itself must be carefully regulated to ensure that miRNAs are not present when their function is not required. However, we know very little about this mechanism and its regulation. I propose carry out a mutant screen and identify genes involved in miRNA turnover. The screen builds on previous work of the host laboratory where miR395, a sulfur starvation-induced miRNA, was characterised. The screening assay relies on a sensor, which is a phloem-expressed GFP transgene containing a miR395 target site, to monitor the level of miR395. Expression of miR395 will be induced by low level of sulfur to down-regulate GFP expression. After replenishing the media with sulfur, miR395 transcription is switched off and the existing miR395 molecules will be degraded, leading to green fluorescence recovery in the seedlings. The speed of this recovery is about three days in wild type plants and I will screen for lines exhibiting faster or slower recovery. After validation of the mutant phenotype I will identify the mutatnt genes by either next generation sequencing or classical map-based cloning. Identifying genes involved in miRNA turnover will open up a new fiekd in the RNA silencing area. Understanding the function of those genes and how miRNA turnover is regulated will impact on all aspect of plant biology but also on biomedicine as siRNAs are potential theraputics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Gravitational Self-Force and Post-Newtonian Methods for Gravitational Wave Detection' (GravityWaveWindow).

assistant: **Innovation**

In the last 7 decades, leaps have been made in astrophysics in their ability to open new windows onto our universe. With every new window, came exciting new detections of the already known and as well as the unknown. We are now once more on the cusp of activating a new probing tool for revealing the secrets of our universe – gravitational wave astronomy. Gravitational waves (GWs) are ripples in space-time that are predicted by Einstein’s theory of relativity. They are unique in the fact that they are the only type of radiation that can be emitted by black holes; allowing their direct detection. GW astronomy also brings with it the exciting opportunity for tests of general relativity as well as other gravitational theories.Black hole binaries (BHBs) make up a large number of systems that will be detectable by both ground and space based detectors. Detection, however, requires the accurate modelling of their waveforms, which in turn requires solving the two-body problem in General Relativity. The two-body problem in general relativity is a longstanding open problem going back to work by Einstein himself. With these advances in GW detector technology, this age-old problem has been given a new lease of life and is motivating numerical, analytical and experimental relativists to work together with the prospect of opening up this new window onto our universe.This research will investigate the 3 current methods used to model BHBs, post-Newtonian (PN), Gravitational Self-Force (GSF) and Numerical Relativity (NR). The inital phase will involve the expansion of PN and GSF, under the supervision of world-leading experts. In the return phase, this newly gained knowledge will be combined with that of the hosts experts in NR and GSF to produce a cohesive outlook of BHB modelling, bot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Supporting the Electric Vehicle REVOLUTION through maximising EV Range and End-of-Life Vehicle Recovery through optimisation of recycled plastics and advanced light materials' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

REVOLUTION focusses on overcoming the challenges hindering the use of recycled materials, but more broadly, restricting the widespread adoption of circular economy principles in the automotive industry. Forthcoming ELV directives are expected to recognise the potential for plastics to enable a circular flow of materials in the automotive sector. Implementing minimum post-consumer recyclate (PCR) targets in any new plastic components in vehicles are currently being discussed. These targets will disrupt the automotive industry. Currently PCR (closed-loop recycling) forms ~2% of the total plastics demanded across the automotive sector, and are not used in high-value or high-performing areas. REVOLUTION is proposing a disruptive innovation that will bring open-loop recycling to the forefront of automotive injection moulding. The variability of PCR causes a big problem for an industry where failure rates on 1 per million are accepted. REVOLUTION will use machine learning and artificial intelligence to optimise the input of recycled materials and injection moulding process to deliver high-quality parts. The AI-Platform will use data from three areas of the production process to predict part quality when using recycled materials. REVOLUTION will develop this platform, and develop a range of recycled formulations, including self-reinforced materials to deliver innovative components that offer light weighing, superior performance and distinctive end of life advantages for future EVs. REVOLUTION brings together leading organisations from European strong-hold industries such as automotive, chemicals and plastics. The automotive industry is represented by Fiat Chrysler Automobiles through Tofas, CRF and Tier 1s Farplas and MAIER. LyondellBasell, Clariant and Altuglas provide strong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Function and regulation of CRL4s-based ubiquitin-dependent processes for mitotic progression' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Mitosis relies heavily on ubiquitin-dependent degradation of specific protein substrates, mainly by the APC/C and CUL3-RING E3 ligases (CRL3s). In contrast, CUL4-RING E3 ligases (CRL4s) have previously been associated with silencing of gene expression, DNA replication and repair. However, unpublished data from the Peter laboratory suggest that CRL4s may also be important for progression through mitosis. In this grant proposal, I thus present two complementary approaches to investigate the role of CRL4s for progression through mitosis in human cells. First, I will complete an RNAi screen to identify specific CRL4 substrate adaptors and regulators important for correct mitotic progression. Second, I will functionally and biochemically characterize the most promising candidates, which may regulate kinetochore function and faithful chromosome alignment. Preliminary results from a pilot screen performed in our lab, as well as the on-going screen, already indicate several promising candidates required for faithful progression through mitosis. By combining an unbiased large-scale with a candidate approach, I expect to unravel novel functions of CRL4s in mitosis, and identify specific roles for CRL4 substrate adaptors in spindle/microtubules dynamics, kinetochore function, and chromosome attachment. I believe that the proposed experiments cover an important area of fundamental biochemistry and cell biology and will provide important new insights into our understanding of mitosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biodiversity of Freshwater Ecosystems: Status, Trends, Pressures, and Conservation Priorities' (BIOFRESH) targeting Seventh Framework.

assistant: **Abstract**

Scientists and water managers have collected a vast amount of data on freshwater organisms, and yet it is rarely possible to describe the geographic range of an organism. Why is this? It is because the data are dispersed in many locally-managed databases, many of which are not publically available. The bits of the puzzle are scattered, and it is difficult even to find them. What story might they tell if they were combined and easily accessible to scientists, policy makers and planners? Such an integrated and accessible dataset could be used not only to help to protect and take better advantage of the services provided by aquatic ecosystems, but also to make it possible to establish effective regional plans for conservation. BioFresh, a major new FP7 project, will design and provide a single point of access to the extensive information on freshwater organisms that is currently stored in the databases. The BioFresh information portal for freshwater biodiversity will allow scientists and planners to complement, integrate, and analyse quantitative data to discover, evaluate and examine patterns that will shed new light on how freshwater biodiversity responds to global, European, and local environmental pressures. The spatially-explicit data will help to reveal the status and trends of freshwater biodiversity, and the services that it provides. Scientists in the BioFresh consortium will take advantage of the information in the databases that the project links, by using the data to examine how various stressors interact to impact freshwater biodiversity. This work will help to shed light on how future climate and socioeconomic pressures will give rise to global, continental and local responses in freshwater biodiversity. Until now, it has not always been easy to incorporate u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Advancing dryland ecohydrology: factors and mechanisms determining catastrophic shifts'.

assistant: **Concept**

The already fragile delivery of dryland ecosystem services to over two billion people is increasingly threatened by global environmental change. Understanding of factors and mechanisms that govern dryland dynamics and their response to changing conditions and pressure is therefore of utmost importance. The scientific aim of this Action, ECOHYDRY, is to address the ecohydrological processes that determine the stability, resilience and restoration potential of dryland ecosystems. The societal aim is to improve dryland management to navigate the risks and opportunities associated with global change impacts on drylands worldwide. ECOHYDRY will extend the theory of ecosystem structure-function relationships by focusing on the so far less-explored hydrological functions. ECOHYDRY will also contribute to the research field of catastrophic ecosystem shifts by investigating critical factors and processes such as functional diversity, ecohydrological feedbacks, and interacting pressures of different nature that have yet to be addressed. Part of the innovation in the project lies in a methodological approach that formatively couples mathematical models and manipulative experiments of dryland ecosystem dynamics. ECOHYDRY also seeks to systematically translate and share the research achievements through a novel participatory approach that effectively engages stakeholders in the knowledge management process. The multidisciplinary perspective adopted,  combining dryland ecology, hydrology, and social sciences, ultimately aims to provide useful and scientifically-sound information to adapt and increase the resilience of dryland ecosystems to global change impacts, including reliable early warning indicators. In this way, this proposal directly addresses the two cross-cutting priorities