RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ERA CHAIR HOLDER TO ESTABLISH BIOMOLECULAR AND STRUCTURAL MASS SPECTROMETRY FOR THE ANALYSIS OF COMPLEX BIOLOGICAL PATHWAYS' (MASSTRUCT), addressing dissemination and exploitation.

assistant: **Impact**

MASSTRUCT aims at establishing a world class Biomolecular Mass Spectrometry Research Unit and Facility for Excellence in the Biomedical Sciences Research Centre Alexander Fleming, unique in Greece and Southeast Europe. MASSTRUCT will attract and maintain a top-class researcher to build an excellent team to advance research in biomolecular mass spectrometry, structural biology and related dicsiplines at the interface between chemistry and biology. Biomolecular analysis by MS has emerged as a key tool for interrogating the conformational landscapes and interaction networks of proteins and their complexes, thus invaluably improving our understanding of fundamental biological processes, and assisting the development of new drug discovery strategies. While over the past decade, biomolecular MS has made big strides for characterising complex biological systems often intractable by other methods, it remains underrepresented in Southeast Europe and fully absent in Greece. Consequently, there is an urgent need to establish a top-class BioMS Facility. Here, we will address this issue and by establishing an emerging technology in a widening country, we will raise and sustain the research profile of a top-ranked host institute in biomedical sciences, foster wider collaborations in Greece and the wider region and leverage competitive funding and industrial partnerships. This will complement recent and current EU investments in Greece, including other powerful structural approaches such as cryo-Electron Microscopy, NMR spectroscopy, structural and synthetic biology, thus adding significant value to local science, regional economy and the wider society. Ultimately, MASSTRUCT will contribute to reverting the ""brain drain"" in Greece, as well as providing a platform to promote mobility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Mobility and adaptation enabling middleware'.

assistant: **Innovation**

Computers and networking technology are becoming an integral part of our living and working environment. The increasing mobility and pervasiveness of computing and communication enables new services and applications that can improve quality of work and life. However the constant change that characterize mobile environment - e.g. network, battery, light and noise conditions - poses a significant challenge to developers.To retain usability, usefulness, and reliability applications need to adapt to the changing operating environment and the context in which they are used. Existing software development methodology and middleware technology do not support such dynamically adaptive applications. The overall objective of MADAM is to provide software engineers with modelling language extensions, tools and middleware that collectively foster the design, implementation and operation of innovative applications and services for the mobile user and worker. To achieve this objective we will study the adaptivity requirements of mobile applications and develop a theory of adaptation.A set of reusable adaptation strategies and adaptation mechanisms, based on a dynamically reconfigurable component architecture will be developed. Modelling language extensions and tools will enable application designers to specify adaptation capabilities at design time. MADAM will provide prototype implementations of the reference middleware platform as well as the modelling tool extensions. Pilot applications will be developed to validate the approach and the prototype implementations. The project puts considerable emphasis on the dissemination and commercial exploitation of the results. Therefore, strong and focused industry partners are included in the consortium.The MADAM project aims towards simplifyi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Innovative methodologies for the design of Zero-Emission and cost-effective Buildings enhanced by Artificial Intelligence'.

assistant: **Concept**

ZEBAI is an ambitious integrative project in which a broad range of interdisciplinary teams collaborate to develop a new methodology that aims to change the way that Zero-emission buildings are designed, by integrating all interdependent analysis and partial alternative decision-making processes under a holistic approach that allows the evaluation of a design simultaneously taking into account: energy performance, environmental impact, indoor environmental quality, and cost-effectiveness. For this purpose, we will require to develop a database of well-characterised materials and make an estimation of discrepancies between simulated and actual building performance. The methodology that will be used is artificial intelligence techniques to optimise the selection of materials and systems in different aspects of the building design. The AI-assisted methodology aims to make the design process more efficient and user-friendly while incorporating all environmental quality and cost-effectiveness objectives. This approach will enable the optimisation of new architectural designs towards scalable Zero Energy Building (ZEB) design in different climates, usages, and building patterns, with the ultimate goal of achieving a zero-emission building stock by 2050. During the project, we will test ZEBAI methodology with four representative demonstrators (located in Ukraine, Spain, the United Kingdom, and the Netherlands). ZEBAI relies on previously funded European research projects and aligns with several national initiatives in which the partners collaborate.


**Keywords:** Artificial Intelligence, Material characterisation, Zero Emission Buildings, Digital green technologies, Climate-neutral building stock, HVAC systems, Renewable energy, Well-being, Circular economy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'In vivo functional screens to decipher mechanisms of stochastically- and mutationally-induced chemoresistance in Acute Myeloid Leukemia' to be submitted under Horizon 2020.

assistant: **Abstract**

Acute Myeloid Leukemia (AML), the most common leukemia diagnosed in adults, represents the paradigm of resistance to front-line therapies in hematology. Indeed, AML is so genetically complex that only few targeted therapies are currently tested in this disease and chemotherapy remains the only standard treatment for AML since the past four decades. Despite an initial sustained remission achieved by chemotherapeutic agents, almost all patients relapse with a chemoresistant minimal residual disease (MRD). The goal of my proposal is to characterize the still poorly understood biological mechanisms underlying persistence and emergence of MRD.MRD is the consequence of the re-expansion of leukemia-initiating cells that are intrinsically more resistant to chemotherapy. This cell fraction may be stochastically more prone to survive front-line therapy regardless of their mutational status (the stochastic model), or genetically predetermined to resist by virtue of a collection of chemoprotective mutations (the mutational model).I have already generated in mice, by consecutive rounds of chemotherapy, a stochastic MLL-AF9-driven chemoresistance model that I examined by RNA-sequencing. I will pursue the comprehensive cell autonomous and cell non-autonomous characterization of this chemoresistant AML disease using whole-exome and ChIP-sequencing.To establish a mutationally-induced chemoresistant mouse model, I will conduct an innovative in vivo screen using pooled mutant open reading frame and shRNA libraries in order to predict which combinations of mutations, among those already known in AML, actively promote chemoresistance.Finally, by combining genomic profiling and in vivo shRNA screening experiments, I will decipher the molecular mechanisms and identify the functional effectors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing national synergies to enhance malta's effective participation in the eu's fifth framework programme' in the context of a Fifth Framework call.

assistant: **Objectives**

In anticipation of Malta's full association to the FP5 in 2001, this proposal misaimed at developing necessary synergies for effective participation in FP5. The proposal's main emphasis is on strengthening the national set-up for disseminating information on FPS by establishing a sound and timely information network linking the National Contact Points to researchers and entities in the private and public sectors and academia. The proposal focuses on three key thrusts :(i) information dissemination;(ii)the organisation of awareness and training events; and(iii)training visits to the Member State National Contact Point Organisations. The proposal is primarily targeted at addressing the particular needs of SMEs , making up in Malta the bulk of the private sector and having little experience in participating in international programmes, thus requiring special guidance and Support in preparing for participation in FP5.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The mechanism of chain formation on an antibiotic polyether synthase' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The recent cloning and sequencing of the monensin biosynthetic gene cluster has opened up new opportunities for exploring the mechanism of chain synthesis and oxidative cyclisation. The aim of this project is to study the enzymology of the initial modules of the monensin polyketide synthase (PKS) and thus help propose structures for the biosynthetic intermediates.Two complementary approaches will be used:i) chemical synthesis of labelled analogues of the proposed intermediates for in viro and in vitro feeding studies and;ii) genetic manipulations of the monensin cluster in order to probe for partially processed intermediates on the pathway.Such intermediates would provide specific substrates for direct assay of purified recombinant PKS and of the enzymes that are responsible for oxidative cyclisation. Enantiomerically pure labeled di-, tri- and tetraketide units, analogues of the proposed interrnediates after module 1, 2 and 3 of the monensin PKS respectively , will be synthesised, and used for in vivo feeding studies. Their fate will be monitored by isolation of labelled metabolites and characterisation by using NMR or mass spectrometry . Meanwhile, truncated versions of the monensin PKS multienzyme will be constructed containing either the first 1, 2, 3 or 4 modules ofthe monensin A-producing PKS. The covalent C-terminal attachment of a thioesterase that catalyses chain release from similar PKSs will allow the truncated polyketide to be released from the enzyme for identification The results should reveal the intriguing enzymology of oxidative cvclisations, and clearly show the relationship between polyether and macrolide biosynthesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Politics of Reading in the People’s Republic of China' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

READCHINA is the first broad investigation into the politics and practices of reading in the People’s Republic of China (PRC), their interpretation and their impact on social and intellectual change. The main objective of the study is a reinvestigation of literary history and cultural policy of the PRC from the perspective of the ordinary reader. This grassroots approach is innovative in the writing of Chinese literary history as it means turning away from the established focus on authors and the political context. Instead, READCHINA will investigate the social conditions under which texts were read, what influences this had on the lives of individuals, on social, intellectual and literary change in China, and on the modes of production, distribution and consumption of literature.READCHINA considers the reading of literature as part of a wider web of reading materials, including different media and non-fictional texts. Primary sources will consist among others of archival material, field work interviews, autobiographies, marketing materials, statements by fans in online forums, and literary texts. Combining literary analysis with historical and ethnographical inquiry, as well as methods from the digital humanities, READCHINA will contribute to the fields of literary history and literary sociology. Moreover, in combining close readings of texts with distant reading methods, READCHINA will also foster our understanding of the meaning and impact of popular literature in China and of literary theories on reading. READCHINA will thus bring 20th and 21st century China into the global history of reading – especially so, as practices of reading in China have been shaped by different institutions than in the ‘West’: a Socialist State eager to reform its citizens by means of cult
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Applying New solutions for Cultural Heritage protection by Innovative, Scientific, social and economic Engagement' (ANCHISE) targeting Horizon Europe.

assistant: **Abstract**

ANCHISE - ‘Applying New solutions for Cultural Heritage protection by Innovative, Scientific, social and economic Engagement’ aims at offering to European societies efficient methods, knowledge and toolkit to enhance the protection of cultural heritage against looting and illicit trafficking. Crossing the methodology of networking that has proved its efficiency in the H2020 NETCHER project with the innovative results of new technologies developments (3D/photogrammetry for site monitoring, data engineering and AI for border control object identification and heritage collection protection, spectral fluorescence signature for object authentication), ANCHISE will create an operational set of tools applicable for European contexts and replicable in other situations abroad. The aim of the project is to bring coordinated solutions to the key existing needs in the domain of Cultural heritage protection: 1) Understand, 2) Prevent, 3) Act, 4) Repair.ANCHISE will consist of: 1) a hub of social science, politics and economics (for in-depth results likely to lead to structural evolutions in heritage protection), 2) a large-scale evaluation of technologies and needs, 3) a toolkit of innovative solutions, 4) pilot experimentation areas (museums, border control, archaeological sites), and 5) a unique and wide network of practitioners.9 demonstrations will involve at list 150 practitioners. Guidelines and procedures on the use of ANCHISES tools will be largely disseminated (INTERPOL, PANDORA, institutions in charge of cultural heritage).The Consortium is a strong partnership of leading stakeholders in the fight against illicit trafficking of cultural objects: companies (PARCS, ICONEM, INOV), research centres (FRAUNHOFER, ICCS, Cyprus Institute), universities (French School at Athens, Un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Noncommutative Geometry for Singular Foliations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The Baum-Connes conjecture (BC) is a far-reaching generalization of the Atiyah-Singer index theorem. It uses index theory to establish a link (assembly map) between the K-theory of convolution algebras of geometric origin (analytical side) with homological invariants of the geometric situation involved (topological side), and conjectures that it is an equivalence. Counterexamples to BC were given by Higson, V. Lafforgue and Skandalis. Even so, the injectivity and surjectivity of the assembly map provide far deeper information for the geometric situation involved, as they imply the validity of the Novikov and the Kadison-Kaplansky conjectures.The purpose of this research proposal is to formulate and study BC for singular foliations. They are the most common ones (e.g. in dynamical systems, control theory, math. physics, Poisson geometry, etc.), and the least well-studied. Particularly, it will show that the injectivity/surjectivity of the assembly map, depends only on its behaviour on each stratum of equal-dimensional leaves.The project will build on important recent results on singular foliations by I. Androulidakis and G. Skandalis. Extending work of Connes on non-Hausdorff groupoids, they attached to a singular foliation the holonomy groupoid and the convolution algebra(s). They also defined the associated longitudinal pseudodifferential calculus and the associated analytic index map. Work of Baum, Connes, Higson, as well as Le Gall and Tu shows that these are all the necessary ingredients to define the assembly map.This 2-years project will be carried out in Greece (Univ. of Athens, Math. Dept.), where Androulidakis holds an Assistant Professorship (tenure). Apart from enhancing Androulidakis' perspective of permanent employment there, it will contribute to the trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Abnormal proteins in the pathogenesis of neurodegenerative disorders' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Degenerative disorders of the nervous system including Alzheimer's, Parkinson's, Huntington's, motor neuron and prion diseases are among the most debilitating illnesses, putting an enormous strain on both social and health care budgets in Europe. As these diseases progress, all but the most primitive functions of the nervous system are lost due to the degeneration and subsequent death of nerve cells. Eventually patients die in a state of incapacitation. Only a small fraction of cases can be accounted for by gene mutations. Altogether, the underlying aetiologies are poorly understood. A hallmark common to these neurodegenerative disorders is the deposition of abnormal protein aggregates. There is currently no treatment available that can halt or prevent, let alone reverse nerve cell degeneration. The APOPIS project is designed to apply the unique information provided by sequencing of the human genome to further the understanding of and to develop treatments for these deva¬ stating diseases. By integrating Europe's leading research centres in clinical research, human genetics, cell biology, genomics, proteomics and bioinformatics, the VERUM Foundation has devised a consortium to identify genes involved, determine their biological functions, establish their role in the patho-physiological processes and identify novel avenues for early diagnosis, treatment and prevention. The chosen approach is based on human population genetics complemented by the identification of modifier genes in model organisms that express both wildtype and mutant variants of known disease-related genes. The consortium meets the prerequisites for such a project: ground breaking research in functional genomics related to human health, creating synergies with and between national research efforts, teami