RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Photo- And Radical induced Reactivity of Atmospheric Oxidants'.

assistant: **Objectives**

The research program will seek to explore the mechanisms and formation/reaction rates of various oxidizing agents pertinent to tropospheric chemistry, using cutting-edge experimental apparatuses and theoretical methods. Firstly, the decay of carbonyl oxides (Criegee intermediates – CIs) will be explored as an important source of OH radicals – fundamental species for the tropospheric oxidizing capability. This will be achieved via a combination of thermal and collision-free experimental measurements. The rate of appearance of OH radicals will be monitored via time-domain measurements (narrow bandwidth IR pump-UV probe). In such approach, the vibrational activation of various alkyl-substituted CIs promoting OH radical production will be explored. Theoretical calculations will predict the OH formation rate from the CIs in correspondence to the barrier for 1,4 hydrogen transfer en route to the products. Temperature and pressure dependent kinetics for the decomposition of the CIs will be determined under atmospheric conditions using cavity-ring down spectroscopy. Finally, the reactivity of various hydroxyalkyl peroxy radicals (HAPs), formed via OH plus alkenes reaction, will be studied. Direct identification of the in situ synthesized HAPs will be carried out in high vacuum via VUV photoionization coupled with mass spectrometry. Temperature and pressure dependent kinetics will be measured for the reaction of the HPAs with various species at atmospheric conditions via near-IR cavity-enhanced absorption spectroscopy. The effect of water complexation on the reaction rates will be explored. All experimental measurements will be complemented by high level theoretical methods and robust atmospheric modelling for extrapolation of the lab results to the atmospheric context.


**Keyw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Selective Carbon-Carbon Bond Activation: A Wellspring of Untapped Reactivity' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The creation of new molecular entities and subsequent exploitation of their properties is central to a broad spectrum of research disciplines from medicine to materials. Most –if not all- of the efforts of organic chemists were directed to the development of creative strategies to built carbon-carbon and carbon-heteroatom bonds in a predictable and efficient manner. But is the creation of new bonds the only approach that organic chemistry should follow? Could we design the synthesis of challenging molecular skeleton no more through the construction of carbon-carbon bonds but rather through selective cleavage of carbon-carbon bonds (C-C bond activation)? The goal of this work is to develop powerful synthetic approaches for the selective C-C bond activation and demonstrate that it has the potential to be a general principle in organic synthesis for the regio-, diastereo- and even enantiomerically enriched preparation of adducts despite that C-C single bonds belong among the least reactive functional groups in chemistry. The realization of this synthetic potential requires the ability to functionalize selectively one C-C bond in compounds containing many such bonds and an array of functional groups. This site selective C-C bond activation is one of the greatest challenges that must be met to be used widely in complex-molecular synthesis. To emphasize the practicality of C-C bond activation, we will prepare in a single-pot operation challenging molecular framework possessing various stereogenic centers from very simple starting materials through selective C-C bond activation. Ideally, alkenes will be in-situ transformed into alkanes that will subsequently undergo the C-C activation even in the presence of functional group. This work will lead to ground-breaking advances whe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Regulation of gene expression in mammalian mitochondria' (GENEMIT).

assistant: **Concept**

The mitochondrial network produces the bulk part of the energy mammalian cells need through the oxidative phosphorylation process. The importance of mitochondria is underscored by the fact that deficient oxidative phosphorylation causes a wide number of genetic diseases. It is also heavily implicated in age-associated disease and ageing. Expression of mammalian mtDNA is of key importance for maintaining mitochondrial oxidative phosphorylation but studies of the poorly understood regulation of mammalian mitochondrial gene expression offer substantial experimental challenges. In the late 1990s, we felt that the challenges associated with understanding mammalian mtDNA gene expression could only be tackled by a broad interdisciplinary scientific approach. We therefore started collaboration between the Larsson (expertise in mouse genetics, in vivo physiology and cell biology) and Gustafsson laboratories (expertise in biochemistry, recombinant in vitro systems, structural biology) that has been ongoing for more than a decade. The success of this collaborative effort is documented by many joint publications in high-profile journals. Most importantly, we have together molecularly defined the basal mtDNA transcription initiation machinery and discovered a novel repressor, MTERF3, of mtDNA transcription. In this proposal, we present a series of unpublished results showing quite unexpected complexity in the regulation of mtDNA expression. An important part of our proposed work will be to establish how the different levels of regulation of mtDNA gene expression communicate to achieve a coordinated response to physiological stimuli.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Discovery and evaluation of novel butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease' to be submitted under Seventh Framework.

assistant: **Abstract**

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is incurable. A drug candidate specifically inhibiting butyrylcholinesterase (BChE) activity will lead to improved clinical outcome in the treatment of AD. The fellow Qiong Shen (QS) has extensive experience, knowledge and technical skills in research into AD. Previously she developed chemistry and successfully synthesised a series of novel coumarine derivatives. She carried out biological assessment and demonstrated potent anti-chlolineric activity of the compounds. She developed structure-activity relationships and generated several inhibitor drug candidates. In this project, QS will bring her expertise of natural product chemistry and an understanding of the disease to the UoN, where the research in neurodegenerative diseases has been hampered by lack of the expertise and appropriate project. She will start this project by adapting the pharmacophore model she developed previously to generate a class of novel BChE inhibitors. She will prepare a library of heterocyclic compounds possessing novel and diverse structures inspired by natural medicinal molecules. The inhibitory activity against AChE and BChE will be assayed. The drug-likeness of the lead compounds will be further assessed in in vitro ADME/Tox assays. The success of this project will place the UoN at the forefront of research into CNS diseases. In addition, the involvement of QS will allow the UoN/EU to access to wealth of natural medicinal chemistry and compound collections held by her research associates at Sun Yat-Sen University and Guangdong Pharmaceutical University in China. The extensive proprietary and historical compound collections will form a major resource for future collaboration and new drug discovery project starting po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'RAPID BIOTECHNIQUES BASED ON IMMUNOSENSORS FOR IN SITU DETECTION OF LEGIONELLA IN INDUSTRIAL AND ENVIRONMENTAL WATER SAMPLES' to be submitted under Sixth Framework.

assistant: **Abstract**

Legionella pneumophila is found in aquatic habitats especially in potable water systems cooling tower systems heat exchanger systems Human infection occurs through the inhalation of aerosols contaminated by Legionella spp An estimated 8 000 to 18 000 people are stricken with Legionnaires disease in EU 15 alone each year Up to 30 of people who have Legionnaires disease die The conventional method for detection of Legionella is a complicated procedure involving isolation in a selective medium However this method presents several problems including the presence of viable but nonculturable pathogens loss of viability after collection and the long time required for culture and confirmation which takes several days In addition detection is more difficult since Legionella can be inhibited and masked by the rapid or abundant growth of other microorganisms In order to avoid the problems encountered with the conventional analysis method an alternative method for rapidly detecting Legionella with high sensitivity is needed The aim of the proposed project is to develop new bioanalytical instruments in order to arrive at an analytical tool for the in situ detection of Legionella by a rapid and low cost assay The main objective is to develop a magnetoresistive biosensor device employing magnetic particles as biological markers which allow for real time measurements in order to achieve a detection limit of 50 CFU L 1 It will ensure that the Immunolegio device passes the strict threshold level regulation fixed at 100 CFU L 1 and enabling a complete analysis in a total test time of 30 minutes with a minimal enrichment stage...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Seismic Anisotropy and Magma Systems'.

assistant: **Objectives**

Magma movement in the crust at active volcanoes will exert a stress on the surrounding country rock that may or may not be manifest as observable strain (ground deformation) or seismicity (earthquakes). Detecting and understanding this stress is a key to predicting if and when a volcano will erupt. The measurement of seismic anisotropy (the variation of seismic wave speed with direction) using the method of shear wave splitting (SWS) has been used to monitor variations in stress in industry but is generally only available in hindsight to studies of volcanoes and earthquakes. Using SWS to measure stress at active volcanoes holds enormous potential for a monitoring and eruption forecasting tool. Changes in SWS associated with volcanic activity have been detected, although not in real time. Interpretation of SWS observations is usually qualitative, and researchers struggle to use the results to quantify the cause and magnitude of stress variations. This research involves developing a method of using Finite Element Models to calculate seismic velocity variation, strain and stress due to magma movement at active volcanoes to resolve the geometry, volumes and pressures of subsurface magma storage. In particular, the research will be used to understand the relationship between anisotropic seismic velocities and pressurisation of magma reservoirs by inverting SWS data for geomechanical parameters. The models will make use of multidisciplinary constraints such as ground deformation, petrological evidence and seismicity, all of which provide evidence for depths, pressures and timing of magma movement. Case studies will include Okmok Volcano in Alaska, Kilauea Volcano in Hawaii, and Ruapehu and Tongariro Volcanoes in New Zealand. This work will represent a significant advance in o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Community formation in active-matter systems' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Population genetics has undergone a major revolution over the past thirty years thanks to the development of controlled microbial experiments to test the respective roles of randomness, selection, and ecological processes in evolution. For instance, it was shown that, when cell division drives the growth of dense bacterial colonies, fluctuations at the colony's edge generally lead to the emergence of spatial genetic segregation. Most organisms, however, do not spread out because of cell division but instead follow complex nonequilibrium dynamics characterized by self-propulsion and motility-induced collective behaviors. Although such nonequilibrium dynamics have been extensively studied within the new field of physics called active matter, their role in shaping microbial evolution remains largely unknown. The aim of this proposal is to address this issue and investigate the interplay between active matter physics and spatial population genetics. To do so, I will put forward an interdisciplinary theoretical framework that integrates coarse-grained descriptions of active-matter systems with evolutionary and ecological processes. By combining stochastic calculus, field-theoretical methods, and numerical simulations, I will then characterize the emergent phenomenology of such systems. To this aim, the project delves into four consecutive objectives: 1) understand the fate of genetic segregation in motile cellular colony; 2) Study the interplay of motility-induced pattern formation and genetic segregation; 3) incorporate ecological interactions in the framework developed in previous stages; 4) generalize our findings to address highly heterogeneous communities. By achieving these tasks, I aim to unravel the complex dynamics of motile cell colonies, setting the stage for a th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Challenging the public awareness for the european dimension of northern research' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This proposal of round table meetings addresses fundamental questions regarding the dissemination of Northern research to non-scientific audiences in order to enhance their awareness of the European dimension of arctic researches conducted within Europe. The goal is to organize a consortium including both sciences centres, research institutes, information centres, museums and experts in new med. Its duty aims to discuss how to bridge the gap between sciences and public regarding Northern research and more especially about the issues related to the environment on which the European dimension rests. The Consortium will work to develop a framework allowing the exchange of knowledge and of expertise regarding the field of adapting the scientific information to the public and of improving their dissemination. Finally the current project aims to develop a new strategy that should contribute to bridge the increasing gap between science and public by developing new multi-media products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Applications of approximate algebraic geometry in industrial computer aided geometry', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The goal of the project is to evaluate to what extent approximate algebraic geometry can be used in industrial CAGD (computer aided geometric design). The project involves several mathematical domains that can be seen as complementary algebraic geometry, approximation theory and numerical geometry. The project will consist of a case study concerning the detection and treatment of various forms for intersections between geometrical objects like curves and surfaces. From an industrial point of view, the detection of intersections costs traditionally a lot of computation time and the treatment of self-intersections is almost non-existing. This means that one can gain considerable performance by introducing methods that decrease some of the expenses and leave more freedom to designers. We consider intersection techniques based on approximation by implicit curves and surfaces. They should be tested out in order to treat intersections.The goal of the project is to evaluate to what extent approximate algebraic geometry can be used in industrial CAGD (computer aided geometric design). The project involves several mathematical domains that can be seen as complementary algebraic geometry, approximation theory and numerical geometry. The project will consist of a case study concerning the detection and treatment of various forms for intersections between geometrical objects like curves and surfaces. From an industrial point of view, the detection of intersections costs traditionally a lot of computation time and the treatment of self-intersections is almost non-existing. This means that one can gain considerable performance by introducing methods that decrease some of the expenses and leave more freedom to designers. We consider intersection techniques based on approximation by im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Air pollution, antenatal depression and anxiety, and foetus brain development' (PRESSURE).

assistant: **Concept**

Latest research suggests a link between air pollution (AP) and psychological health, including depression and impaired neurodevelopment. In pregnant women, besides mother’s own well-being, antenatal anxiety or depression may result in an abnormal brain development of the offspring generation. However, little evidence is yet available on these fields. Traditionally, epidemiological studies have used modelled ambient AP estimates at home, with biases arising from this simplification. Personal measurements of AP permit the determination of accurate exposure and dose, by considering different environments and physical activity intensities. Moreover, previous studies lack the assessment of possible confounding by noise on the effects of AP. The aims of the PRESSURE Project are to assess the effect of air pollution and noise in mother’s antenatal depression and anxiety and to evaluate the mediation role of mother’s depression/anxiety in the link between AP and the development of brain structures in the foetus. To achieve this aim, (i) I will develop a modelling framework to accurately quantify the exposure and dose of the population to PM2.5, Black Carbon (BC), and NO2 in different time-windows of the pregnancy period by using data from personal measurements in a large cohort of pregnant women (n=1,300); (ii) I will assess the effect of AP and noise exposure/dose on antenatal depression and anxiety (evaluated through questionnaires); and (iii) I will evaluate the mediation role of antenatal anxiety/depression in the association between maternal exposure to AP and structural changes in the growing brain of the foetuses and new-borns through neuroimaging (transvaginal neurosonography and neonatal MRI). This multidisciplinary project may add insight in the fields of exposure ass