RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Predictive Epigenetics: Fusing Theory and Experiment' (PEP-NET).

assistant: **Innovation**

Epigenetic mechanisms of gene regulation are profoundly implicated in human health and disease. However, we are still far from a complete mechanistic understanding of many epigenetic processes. Without an understanding of mechanisms we cannot fully understand function in healthy cells, in disease states, and the effects and side effects of therapeutic interventions. This severely limits the development of healthcare strategies. Research in epigenetics has typically been based on experiments and not on theory. Although this has delivered large amounts of information, information alone is not sufficient. Further progress urgently needs a paradigm shift in the way in which we study epigenetics, namely: epigenetics needs mathematics. Mathematical models are essential to capture and understand the complex, dynamic and stochastic nature of epigenetic regulation. Models are immensely powerful because they identify unifying concepts and enable predictions of system properties. Modelling epigenetic processes not only holds the key to a deep mechanistic understanding, but also ultimately, to drug response predictions, patient-specific diagnoses and new therapies. One of the greatest challenges to uniting biology and mathematics is the barrier between disciplines, because education in each field has traditionally been mono-disciplinary. The PEP-NET ITN will overcome these barriers by uniting 16 outstanding European academic laboratories and companies who have pioneered the successful combination of theoretical and experimental epigenetics. PEP-NET will train a new cohort of 15 European researchers to combine quantitative experiments with predictive theoretical models, and to apply this knowledge to basic and applied questions of epigenetic function.


**Keywords:** Quantitative mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Implementation and evaluation of EU integrated rural development policies in Hungary - adapting the Spanish experience' to be submitted under Sixth Framework.

assistant: **Abstract**

The fundamental aim of our project is to transfer knowledge from old to new Member States, concerning the implementation of EU integrated rural development policies.We would like to follow and facilitate the building of new institutions in Hungary, which started with a pilot programme in 2002 and continues with the implementation of the EU LEADER+ initiative, under the Common Agricultural Policy from 2005.First, we plan to evaluate the Hungarian Pilot LEADER programme, and to explore its medium term effects on the local level, through further qualitative research (interviews, participant observation, focus groups, etc.).Second, we want to investigate the current development of new rural development institutions, including local partnerships, central bureaucracy, and the participating agencies and networks. Action-research will be added to the methodology, and, through the adaptation of western experiences, we hope to make a positive influence on the process.Third, we want to explore tangible outcomes of the EU LEADER Programme from 2006 onwards, with special regard to effects on economic and social problems, empowerment and the involvement of civil society on the local level.The research will provide social scientists with up to date examples on institution building, social dialog and policy implementation, and will enhance knowledge transfer in a very sensitive policy area.Besides journal articles and reports, we plan to develop material for post-graduate teaching and distributing information amongst local development actors. Our international connections would allow us to facilitate the improvement of co-operation between domestic Hungarian and foreign (Spanish, British, Polish, Slovakian, etc.) rural development organisations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next generation multiplatform Ocean observing technologies for research infrastructures' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The ocean is a major component of the global carbon cycle absorbing about a quarter of anthropogenic CO2 emissions every year, modulating the rate of accumulation of carbon in the atmosphere and hence global warming. Increased levels of CO2 in the ocean cause a decline in seawater pH, also known as ocean acidification, with now well-known potential ecological consequences. Sustained, long-term in situ observations are, therefore, crucial to better understand and predict the impact of climate change on ocean ecosystems, increase resilience and develop sound mitigation and adaptation strategies. Furthermore, long-term sustained in situ ocean observations are required to support environmental and climate policies, such as the European Green Deal, and related policies aiming to reach net zero carbon and achieve a sustainable blue economy. To meet this challenge, GEORGE will advance the global technological competitiveness of European ocean observing research infrastructures (EMSO, ICOS, Euro-Argo) through the development and demonstration of a state-of-the-art biogeochemical, multi-platform observing system for characterisation of the ocean carbon system. GEORGE will advance the technology readiness level of novel sensors enabling for the first time systematic autonomous, in situ seawater CO2 system characterisation, and CO2 fluxes on moving and fixed platforms. These sensors will be integrated on state-of-the-art platforms augmented with the latest in autonomous technology enabling new observing capability. Technologies, methods and SOPs for carbon observing will be harmonised across a framework for multi-platform, cross-ERIC ocean observing, from sensor to data repositories. GEORGE will build capacity in ERICs through the provision of training in the use of new technologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Equilibrium Rejection of a Mechanism' in the context of a Seventh Framework call.

assistant: **Objectives**

The objective of this research project is studying mechanism design problems, where rejection of the mechanism does not end the strategic interaction between the potential participants. These post-rejection interactions will be modeled as a ""default game"" which accepts the potential participants of the mechanism as its ""players."" The existence of this default game has significant effects on mechanism design. How the potential participants would act in the default game after a possible rejection of the mechanism depends on what they have learned about each other during the negotiation of the mechanism. With her choice of the mechanism, the designer regulates the extent of the information to be revealed when this mechanism is rejected. In other words, by offering a mechanism, the designer also determines the nature of the alternative to follow after a possible failure of this mechanism.The preliminary results of the project suggest that the designer may deliberately offer a mechanism which has the potential to be rejected so that the act of rejection carries relevant information about the ""rejecter."" This is in contrast to the standard design setup, where a designer can achieve any feasible goal through mechanisms that are always accepted unanimously.The possibility that the designer may achieve some outcomes only by rejection of her mechanism presents a difficulty in the characterization of what is feasible for the designer. The proposed research aims to develop in the following two directions to overcome this setback:i) Establishing sufficient conditions on the default game under which the rejection of a mechanism is not desirable for the designer.ii) Suggesting a new definition for the term ""mechanism"" which incorporates the negotiation process that often follo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Is rodenticide use disrupting the natural autoregulation of vole populations?'.

assistant: **Innovation**

Humans modify ecosystems to maximise benefits from natural resources and as a result wildlife adapts ecological relationships. For instance, voles show multiannual population cycles and predators respond numerically, possibly limiting vole populations. Voles also damage crops and reduce food available for livestock. Subsequently, farmers respond using anticoagulant rodenticides (ARs) to control voles. That means indirect control of predators by secondary exposure or by reduction of food sources. Therefore, ARs will be acting analogously as a superpredator, impeding the natural autoregulation of vole populations. Here the Experienced Researcher will become an ecologist and ecotoxicologist and learn to use cutting-edge Bayesian state space models to determine the superpredator role of ARs in both predator and prey dynamics. To do that, he will work in the Universities of Franche-Comté (UFC, France) and Aberdeen (UNIABDN, UK), the Doubs Hunting Federation (FDC25), but also work hand-in-hand with farmers, stakeholders, etc. about vole populations in western Europe. He will also collaborate with small mammal work groups involved in research about small mammal surges. By combining multidisciplinary and intersectoral knowledge, the project will address the deleterious effect of pest control by poisoning ecosystems. In addition, it will show predation as one underestimated tool for pest control. By direct contact with interested parties, the Experienced Researcher will become fully involved with groups related to the hunting industry, among others, which will enable him to develop consultancy services about small mammal pests and control methods. He will also boost his research carrier and become a senior post-doc dealing with strongly applied issues of ecology and ecotoxicolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Energy oriented Centre of Excellence for computer applications' in the context of a Horizon 2020 call.

assistant: **Objectives**

The aim of the present proposal is to establish an Energy Oriented Centre of Excellence for computing applications, (EoCoE). EoCoE (pronounce “Echo”) will use the prodigious potential offered by the ever-growing computing infrastructure to foster and accelerate the European transition to a reliable and low carbon energy supply. To achieve this goal, we believe that the present revolution in hardware technology calls for a similar paradigm change in the way application codes are designed. EoCoE will assist the energy transition via targeted support to four renewable energy pillars: Meteo, Materials, Water and Fusion, each with a heavy reliance on numerical modelling. These four pillars will be anchored within a strong transversal multidisciplinary basis providing high-end expertise in applied mathematics and HPC.EoCoE is structured around a central Franco-German hub coordinating a pan-European network, gathering a total of 8 countries and 23 teams. Its partners are strongly engaged in both the HPC and energy fields; a prerequisite for the long-term sustainability of EoCoE and also ensuring that it is deeply integrated in the overall European strategy for HPC. The primary goal of EoCoE is to create a new, long lasting and sustainable community around computational energy science. At the same time, EoCoE is committed to deliver high-impact results within the first three years. It will resolve current bottlenecks in application codes, leading to new modelling capabilities and scientific advances among the four user communities; it will develop cutting-edge mathematical and numerical methods, and tools to foster the usage of Exascale computing. Dedicated services for laboratories and industries will be established to leverage this expertise and to foster an ecosystem around
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modelling of interfaces for high performance solar cell materials' to be submitted under Seventh Framework.

assistant: **Abstract**

The resistance at the metal contact-semiconductor interface and recombination at the passivating layer-semiconductor interface are two important bottlenecks for improving the performance of current solar cells. These processes are quantum mechanical by nature, but so far most studies and attempts to improve the properties of solar cells have been at the device scale. A main reason for this is the great challenges faced by theoretical modelling. Accurate descriptions of the geometric and electronic structures are required, which necessitate the use of highly sophisticated methodologies based on first principles. At the same time, the interfaces extend in many cases well beyond the size limit of first principles methods, creating the need for more efficient methods, which can operate at larger time and size scales. HiperSol aims to fill this knowledge gap by developing and implementing a multi-scale modelling environment. The physics at the various scales will be treated by a multitude of techniques, and the boundaries between these techniques are of utmost importance for the success of this project. Hence, considerable emphasis will be laid on integrating different methods seamlessly and consistently, with many possibilities to update and improve the different tools. An important development will be the implementation of semi-empirical pseudo-potentials, which can calculate the accurate electronic structure of large structures with up to millions of non-equivalent atoms as well as methods for calculating the lifetime of charge carriers. The multi-scale environment will involve construction of reliable inter-atomic potentials for empirical molecular dynamics, providing input to first principles calculations that in a following stage will be integrated into finite element
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Spectroscopy in cells  with tailored in-vivo labelling strategies  and multiply addressable nano-structural probes' to be submitted under Horizon 2020.

assistant: **Abstract**

This project proposes to combine complementary spectroscopic approaches and push the domain of molecular spectroscopy for structural biology and biophysics into the living cell. Non-invasive molecular spectroscopy to probe protein dynamics and structures at the molecular level is essential for unravelling one of the most challenges in Chemical Biology - the complex physical mechanism of life. Of particular interest are electron paramagnetic resonance (EPR) distance measurements in the nanometer range, especially, when they will be combined with complementary spectroscopic techniques. By now, different spectroscopic approaches require specific labelling strategies and probes. In this project, we will develop multiply-addressable nano-structural probes that are in parallel suitable for various spectroscopic techniques, e.g.  magnetic resonance spectroscopy (NMR and EPR), vibrational spectroscopy, and optical (including single molecule) spectroscopy and microscopy. This enables obtaining information on all relevant length and time scales for the very same sample. Labelling will be performed directly in the native intracellular environment, where the proteins are folded, modified, transferred and degraded. Corresponding spectroscopic experiments can be combined or re-arranged for novel experiments even in cellula.Current characterization methods for structure and dynamics of proteins are generally applied in vitro. In the cell, posttranslational modifications, crowding effects, organelle specific localization, or non-specific or specific interactions with cellular components significantly affect structure and conformational equilibria of proteins. We will demonstrate that novel in-cell spectroscopy approaches developed within the SPICE-project using multiply-addressable nan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of histamine dysfunction in sensory and cognitive deficits in schizophrenia' under Seventh Framework.

assistant: **Concept**

The aim of this study is to investigate the role of the neurotransmitter histamine in sensory and cognitive deficits (e.g. hearing voices, disturbed thinking and planning, memory problems) as they are observed in patients suffering from schizophrenia. The ideal location to conduct the study and to obtain a unique learning experience is at the Institute of Psychiatry, London United Kingdom, where staff comprises a mix of leading experts in the field of schizophrenia and experimental drug treatment as well as specialists in Magnetic Resonance Brain Imaging. The pharmacological treatment of psychotic symptoms including sensory and cognitive deficits as seen in schizophrenia remains partially unsuccessful due to side effects and treatment resistance. Therefore, new treatments are continuously developed by pharmaceutical companies. The neurotransmitter histamine is a promising target for new drugs. Histamine turnover in the brain has been suggested to be increased in schizophrenia which may underlie the positive symptoms. A decrease in histaminergic activity in the frontal cortex has been suggested to underlie the cognitive deficits. No attempts have been made until now to investigate the specific role of histamine in sensory and cognitive deficits typically seen in schizophrenics. To investigate this, I will assess the effects of increased histaminergic activity, by blocking the H3 receptor in healthy volunteers, on sensory gating and tasks of executive functioning (planning) and memory. Altered performance on such tasks would support the importance of histamine in schizophrenia and provides a model for new drug development in order to treat the sensory and cognitive deficits.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Recycling of end of life battery packs for domestic raw material supply chains and enhanced circular economy' in the context of a Horizon Europe call.

assistant: **Objectives**

BATRAW main objective is to develop and demonstrate two innovative pilot systems for sustainable recycling and end of life management of EV batteries, domestic batteries, and battery scraps contributing to the generation of secondary streams of strategically important CRMs and battery RMs. The first pilot will deliver innovative technologies and processes for dismantling of battery packs achieving recovery of 95% of battery pack components and separating waste streams including cells and modules by semi-automated processes for recycling. BATRAW's second pilot will scale and demonstrate efficient pre-treatment and continuous hydrometallurgical recycling of battery cells and modules including innovative steps for C-graphite, Al and Cu separation from black mass and Mn extraction, achieving a recovery of the full range of battery RMs (Co, Ni, Mn, Li, C-graphite, Al and Cu) at selectivity of 90-98%. Innovations wil be scaled and demonstrated in a pilot systems with recycling capacity of 1 ton lithium-ion battery (LIB) packs dismantled per shift (8 hours) and treat 300 kg BM per day. BATRAW outcomes are of strategic importance within the prospects of the exponentially growing EU battery market and reducing EU import dependency of CRMs. The project will further promote the overall sustainability and circularity of battery products and raw materials by developing new procedures for battery repair and reuse, enabling faster diagnostics and conversion of EV packs into second life batteries, delivering eco-design guidelines for battery manufacturing,  demonstrating blockchain platform for raw material tracking and supply chain transparency (Battery Passport) and delivering guidelines for safe transports and handling of battery waste. The project aims to maximize market uptake and