RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next Generation Proteomic Analysis of  Pre-Ribosomal Proteome Dynamics Coupled to Glucose Metabolism in Caner Cells' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The research field of proteomics proceeds rapidly thanks to recent technological advances of instrumentation, methodology,and software development. Next Generation Proteomics (NGP) refers to the integration of these three areas to provide asystematic approach for measuring proteome dynamics in both time and space during various cellular responses. In thisproposal, I will analyze pre-ribosomal proteome dynamics in response to intracellular energy status using a NGP approach.Specifically, I will determine how cancer cells regulate Ribosome Biogenesis (RiBi) to aid their survival under conditions ofenergy deprivation, which frequently occurs in connection with solid tumour development. The host laboratory is well knownfor developing and applying NGP strategies and will provide me with training and access to all of the equipment andresources required. To carry out this project I will first optimise methods for purification of human pre-ribosomal particles,combining my existing knowledge of RiBi with expertise from the Lamond group in nucleolar isolation. I will then use aquantitative proteomics approach to analyze pre-ribosomes isolated from cells grown under conditions of varied glucosedeprivation. I will compare the components of pre-40S, pre-60S and pre-90S particles, respectively, using SILAC and thePepTracker software developed in the Lamond group. This project is based on my recent data showing that 47S pre-rRNAprocessing, which occurs in pre-90S particles, is suppressed by glucose deprivation in human adenocarcinoma HeLa andMCF7 cell lines. As the proteins contained in human pre-ribosomes are less well characterised than the correspondingyeast proteins, I will incorporate these results in a searchable database of human RiBi factors that will be freely available tothe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Clinical variability of american tegumentary leishmaniasis in Peru and Bolovia - relationship with polymorphism of the parasite within the leishmania braziliensis complex of species - syn, subgenus viannia', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To identify parasite characters linked with variability in clinical response to infection with parasites of the Leishmania braziliensis complex in Peru and Bolivia:* To collect and analyse comparable clinical and epidemiological data from three endemic areas in the Amazon basin of Peru and Bolivia in order to discriminate factors underlying clinical variability in infection and disease.* To strengthen the argument that there is apparently a consistent association between parasite genetic variation, virulence and clinical variability.* To initiate experimental studies on biological parameters that might be involved in Leishmania virulence, by using isolates with well defined genotypes obtained from representative clinical categories.Expected Outcome* Comparable epidemiological, ecological and clinical data in the three study sites of Peru and Bolivia (Andean valleys, Amazonian foothills, Amazonian lowlands).* Collection of parasites from isolates and in biopsies, characterized genomically and genetically according to clinical grading.* In vivo and in vitro models for biological characterization of parasite virulence.* Discrimination of factors underlying clinical variability in infection and disease.* Documenting whether there is a correlation between parasite genetic variability and clinical variability. If there is a correlation, validation of (i) corresponding risk factors for patient's care, and of (ii) corresponding probes and primers for parasite identification in field biopsies.* Genetic structure of parasite populations in the three study sites.* To collect comparable epidemiological and ecological data in the two previous STD3 (LEISHBOLPE 3) study areas (Pilcopata, Amazonian foothills, Peru; Isiboro Secure, Amazonian Iowlands, Bolivia) in reference to the method
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Molecular Anatomy and Pathophysiology of the endoplasmic reticulum-mitochondria interface'.

assistant: **Concept**

Organelles are not randomly organized in the cytoplasm of the cell, but often are orderly arranged in mutual relationships that depend on physical, protein bounds. Understanding the molecular nature of the tethers that regulate relative position and juxtaposition of the organelles is one of the main quests of cell biology, given their functional importance. For example, the juxtaposition between mitochondria and endoplasmic reticulum (ER) has been suggested by us and others to crucially impact on Ca2+ signalling and apoptosis. We recently identified the first structural ER-mitochondrial tether in mitofusin 2 (Mfn2), a pro-fusion mitochondria-shaping protein. A fraction of Mfn2 is also located on the ER regulating its morphology, and acting in trans to tether it to mitochondria. The tethering function of Mfn2 impacts on the transmission of Ca2+ signals between the two organelles and is regulated by the oncosuppressor trichoplein/mitostatin. Mfn2 is likely only one of the tethers, as others exist in yeast. Furthermore, the dynamicity of the ER-mitochondria contact is known, but remains poorly understood. Therefore, a clear picture of the anatomy and pathophsyiology of ER-mitochondrial connection is far from being reached.Here we hypothesize that ER-mitochondrial contacts are crucial specialized hubs of cellular signalling whose architecture is modulated by cellular cues, impacting on integrated signalling cascades and ultimately affecting cellular function. To address this hypothesis we wish to setup a research project that aims at (i) increasing our knowledge on the molecular nature of tethers and modulators of ER-mitochondrial tethers in mammalian cells; (ii) clarifying how mitochondrial and ER function are controlled by the tethering; (iii) addressing how juxtaposition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Macro Experiments on Reflexivity and Economic Crises'.

assistant: **Concept**

The MacroReflEx project studies fiscal policy design in the aftermath of an economic and a sovereign debt crises, like the ones that the Euro area has experienced following the 2007-8 financial crisis. The key research question is whether or under which conditions fiscal consolidation or fiscal stimulus is more desirable in such an economic downturn. Expectations of the economic actors play a central role, both in worsening economic downturns and in determining the success or failures of policies. For this reason, the project uses an original combination of laboratory experiments and heterogenous agent models that both put a strong emphasis on the understanding and the modeling of expectations dynamics. Controlled laboratory environments recreate an environment in which expectations play a key role in shaping the aggregate dynamics, just like in real economies, but without assuming a specific expectation mechanism that may influence the conclusions of the exercise, as forecasts are directly elicited from the subjects. The experiments will shed light on three issues: Under what conditions can one observe bubble-like behavior that may amplify negative shocks? Are policy announcements able to revert those expectations and dampen those amplification mechanisms? If spreads are partly driven by non-fundamental factors, does it call for more fiscal consolidation or more stimulus?  The project then elaborates on the forecasts data collected in the experiments, and develops an heterogenous agent model with two objectives. First, the resulting model will provide a behavioral explanation of the observed patterns in the experiments. Second, it will allow us to perform a systematic policy analysis, both regarding ex ante, preventive policies, and ex post, counter-cyclical interventi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Early physics studies and calibration of the ATLAS muon trigger', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Operating at the highest energies of any particle accelerator, the Large Hadron Collider (LHC) will open new frontiers in the study of elementary particle physics. Analysis of the large data sets collected by the LHC¿s ATLAS detector will help to address longstanding gaps in the understanding of the universe at the particle physics level. A critical task during the first two- year data taking will be to calibrate the detector and improve its operation while beginning to conduct initial physics studies.I propose to use the early ATLAS data to measure the efficiency and background rate of the muon trigger, and employ di-muon final states to begin a physics analysis program in the areas of quantum chromodynamics, B physics, and physics beyond the standard model. This will be done through measurement of the polarization of prompt J/psi mesons, study of semi-muonic penguin B decays, and a search for heavy new particles decaying to a pair of muons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Animal Farm:  An Architectural History of Intensive Animal Farming (1570–1992)'.

assistant: **Concept**

The architecture of intensive animal farming is a pervasive phenomenon of the global built environment, yet little is known about the buildings in which farming occurs. If architectural history is often a history for and by humans, what happens when we apply the tools of this discipline to investigate the zootechnical buildings designed to host livestock? AnimalFarm explores the architectural history of animal farming between Europe and North America, since the modern era and until the present day. Recent architectural historiography has developed an interest in the relationship between humans and other forms of life. Yet, the buildings of animal farming are usually perceived as atemporal, anonymous, and ethically uncomfortable. From sixteenth-century Palladian villas to today’s concentrated feeding operations, Western architecture has evolved along the entanglements between humans and domesticated animals – mostly cattle, pigs, poultry, and horses. Over the centuries, the practice of animal farming has been a pivotal field for spatial, material, and technological experimentations. AnimalFarm employs the methods of architectural history to investigate the print sources, such as treatises, handbooks, and journals, that allowed animal farming to become a transnational and scalable model. The research is conducted on three geographical and chronological strands, that embrace the beginning of agrarian capitalism (1500s-1600s), the dawn of zootechnics (1700s-1800s), and the great industrial acceleration (1800s-1900s). AnimalFarm pioneers a novel research methodology that contaminates the perspective of architectural history with three interdisciplinary layers: critical animal studies, history of veterinary medicine, and history of labor. AnimalFarm ultimately explores the hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'RAtional design of canceR ImmunoTherapY: one size does not fit all' under Horizon 2020.

assistant: **Concept**

Checkpoint blockade immunotherapies have revolutionized cancer treatment. However, this immunotherapy only benefits a minority of patients (< 15%), mainly those diagnosed with cancers having many mutations. Furthermore, checkpoint blockade therapy does not selectively activate cancer-reactive T cells.RARITY responds to these shortcomings, aiming to provide innovative solutions for the development of effective immunotherapies for patients who do not benefit from current treatments. The ground-breaking preliminary data included in this application demonstrates that cancer-reactive T cells can be naturally present in so-called non-immunogenic cancers and that they acquire distinctive phenotypes. RARITY will apply state-of-the-art technologies to fingerprint these phenotypes. This will allow the isolation of cancer-reactive T cells from tumour tissues and their employment as highly-effective therapies. Therapeutic vaccination with cancer antigens can also be used to induce T cell responses in patients where natural activation of cancer-specific T cells is not detectable. However, the applicability of vaccination is compromised by the lack of specific targets, particularly in malignancies with few mutations. RARITY will address this problem by deploying a novel class of cancer antigens. An unprecedented screening of non-exomic genomic regions will be done to detect unannotated proteins that arise from de novo transcription and translation events. These proteins can then be targeted by personalized immunotherapies. Finally, thought-provoking findings included in RARITY suggest that immune cell subsets other than T cells play a major role in anti-tumour immune responses. These subsets need to be fully inventoried and categorised so that complementary strategies to T cell immun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Generation of a detailed structural and functional map of human poly - a - polymerase', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

SUMMARY  All mammalian mRNAs end with a 200 adenosine residues tail at their 3' ends. Recently several studies have highlighted the role of the poly(A) tail in translation and mRNA stability. A detailed biochemical characterization of the protein components involved in the nuclear polyadenylation have started during last years. Poly(A) polymerase (PAP), necessery for the adenosine addition reaction, has been molecularly cloned from bovine and human. The availability of purified polyadenylation factors and monoclonal antibodies (Mabs) directed against human PAP makes it possible to generate an epitope map of PAP describing the relative location in space of the different epitopes. The epitope map will be related to a linear map which will be obtained by deletion mutagenesis of recombinant PAP followed by Western blot analysis of the various modified PAPs. Comparison of the linear functional maps with the tentative folding map, will allow us to predict a detailed functional/ structural map of PAP. The identification of different epitopes of PAP and their function, will help us to understand the significance of multiple PAPs in mammalian cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ekowasher Graffiti Blaster - A Closed-loop system for Environmentally Optimized Cleaning and Decontamination' (EWGB2000) under Horizon 2020.

assistant: **Objectives**

The environmental costs of graffiti removal procedures make them far more expensive than the financial estimations may express. An ordinary graffiti removal procedure requires many cubic meters of drinking water. Waste water is spread around contaminating ground water and causing high exposure of humans (especially children) and animals to the hazardous aerosols. Currently water shortages affect at least 11% of Europeans and in 20 years from now, global water demand is likely to exceed water supply by 40%. As a result, prices for drinking water might significantly rise. The cleaning industry companies are searching for efficient tools that would balance the rising environmental requirements with their economic efficiency. Ekowasher Sweden AB offers an unique closed loop system where the residual products are separated and the wash water is purified by a combination of filters and reused. The water consumption of the Graffiti Blaster is almost zero. Through the specially designed washing nozzles, various surfaces of different porosity can be washed. As the washing water is collected and recycled inside the Graffiti Blaster, the risk of contaminating pollutants being spread by the wash water and the wind is minimized. The Graffiti Blaster’s environmental performance surpasses all other market-available solutions. In this project we will conduct a deeper analysis of the technical feasibility and of potential ergonomic improvements of the Graffiti Blaster. We will identify the necessary adjustments required for further expansion of the Graffiti Blaster across other industries and market segments. We will conduct an economic feasibility assessment that will indicate the perspectives of entering foreign markets. Moreover, we will investigate business opportunities that may ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Silicone cross-linked polyurethane materials for thrombus and biodegradation resistant small-diameter vascular grafts and coating of blood contacting devices'.

assistant: **Concept**

The objective of the project is to synthesize new functional silicone based materials (SILCROTHANE) with very low thrombogenecity activity and optimal biostability, and to process the new material by proprietary processing technologies to fabricate the following pre-clinical devices:- a medium-diameter SILCROTHANE coated Dacron vascular grafts,- a SILCROTHANE coated, stainless-steel 316L, balloon expandable vascular stent,- a small-diameter vascular grafts made entirely of the SILCROTHANE material.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European science communication teachers network' (1998-2002).

assistant: **Innovation**

We propose to establish a European network of science communication teachers with a view(i) to exchanging best practice(ii) to developing a European module for science communication(iii) to constructing science communication workshops for scientists involved with European research projects(iv) to acting as a centre for further expansion and continuation of the network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of innovative FunctiOnal aiRcraft MOveable SurfAces' (FORMOSA).

assistant: **Innovation**

The present project is addressed in the framework of CleanSky 2 Fast Rotorcraft (FRC) IADP. In this context, the Next-Generation Civil Tiltrotor (NGCTR) demonstrator will be dedicated to the design, construction and flying of an innovative Civil Tiltrotor technology demonstrator, the configuration of which will go beyond current architectures for this type of aircraft. Indeed, demonstration activities planned in this framework will be aimed to show significant improvement with respect to current tiltrotors’ state-of-the-art.In particular, this novel tiltrotor configuration will host a peculiar wing that includes several movable surfaces controlled by complex kinematics mechanisms that will be flight tested in the framework of Clean Sky 2. The wing design was conceived to assign a specific function for each movable surface. An inner large flaperon was conceived for download reduction (flap role) while an external flaperon was conceived for roll control as well as for download reduction. The design of the future NGCTR will encourage an innovative solution for the wing movable surfaces able to incorporate multiple functions (download alleviation, flap, aileron) thus reducing the complexity of the actuation system.


**Keywords:** Flaperon, Download Alleviation, Innovative Kinematics, Morphing, Tiltrotor Movable Surfaces