RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Thorium cycle: development steps for PWR and ADS applications' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The use of the thorium cycle offers challenging options for nuclear waste reduction, both at the back end and the front end. The objective of the proposed work is to supply key data for application of the Th- cycle in PWRs, FRs and ADS, related to Pu/TRU burning and reduction of the lifetime of nuclear waste. To achieve this, the irradiation behaviour of Th/Pu fuel at high burnup and for relevant neutronic conditions will be examined. Vital data for geological disposal scenarios will be determined, and new waste-minimizing routes for reprocessing of thorium based fuel will be investigated. The very high Pu/TRU consumption in Th/Pu fuel will be validated by full core calculations and essential nuclear data for these core calculations will be determined experimentally.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of novel vaccines by attenuation of M.tuberculosis'.

assistant: **Objectives**

The main objective of this project is to gather several teams with complementary expertise to produce and evaluate new attenuated strains of M. tuberculosis as vaccine candidates. This project includes teams from 5 different European countries (France, Great Britain, Denmark, Belgium, and Spain) and an industrial partner (Pasteur Mérieux Serums et Vaccins) who has extensive expertise in the development of vaccines. We propose to generate attenuated strains of M. tuberculosis by disrupting genes involved in the pathogenesis capacity. Some potential targets for gene disruption have already been identified and will be deleted by allelic exchange. Other target will be identified either by random transposon mutagenesis or by homology with virulence genes of other bacteria. Induction of protection by attenuated M. tuberculosis strains will be evaluated in mouse and guinea pig models and compared with protection conferred by BCG. This project has been made possible by the construction of genetic and immunologic tools as a result of previous collaborative studies between the different teams and by the availability of sequences coming from the ongoing TB genome project. These tools will be further developed during the course of this project. They should be valuable for many other studies on mycobacteria, including the search for new diagnostic reagents and newefficient drugs against M. tuberculosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Regulating RAS Activity to Target RAS-Driven Cancers' (RASATaC) under Horizon 2020.

assistant: **Objectives**

More than a quarter of all cancers are driven by mutations in the RAS family of genes. Considering the key role of these oncogenes, and despite intensive effort, no effective anti-RAS strategies have successfully made it to the clinic. In our ERC-CoG project, we found that a class of scaffold proteins, expressed in cancer, bind to active/mutated forms of RAS proteins to moderate RAS signalling. Accordingly, we find that loss of one of the scaffolding protein isoforms in RAS-mutant cancers triggers cytotoxic signalling, leading to cell death. As such, drugging this scaffold protein could not only i) represent a completely innovative approach to target RAS-driven cancers that exploits the oncogene’s function, but also ii) deliver the first truly effective cancer treatment for patients that do not respond to current standards of care. In this ERC-PoC, we aim to prove that therapeutic targeting of the scaffold protein is effective in vivo, and to explore the commercial avenues to exploit this finding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of models for the prediction of the in-service performance of mmc componets' (1994-1998) under Fourth Framework.

assistant: **Objectives**

For the European transport industries, saving weight, cost and energy and also improving the performance of components are major economic issues. Therefore, in the last decade, the automotive and aeronautical industries have demonstrated the feasibility of introducing in transport applications aluminium based + particulate reinforced MMC structural eomponents, formed via standard metallurgical processes. The final objective of the project is to develop a set of complementary models to predict the in service performance of particulate reinforced MMC automotive and aerospace components. These models will address fatigue and crack growth at typical in service temperatures which are key issues in terms of inservice performance for most automotive and aeronautical parts: macroscale fatigue, crack growth and design models will be extended in order to take into account the influence of the composition and microstructure oi MMCs via a micromechanical approach of the constitutive behaviour of MMCs at room and high temperatures. The models will provide for a given MMC component and associated in service operating conditions (loading, temperature):  the critical zones with a risk of internal damage, crack initiation and failure.  the fatigue life (failuretnon failure, number of cycles to crack initiationtto failure)  the growth of cracks that may initiate from defects (scratch, corrosion, ...). These models will be used for the optimisation of the components design and life and also for the establishment of maintenance programmes, more particularly in the critical zones. These models will also be applicable to the prediction of the iniluence of the MMC composition (matrix, type and volume fraction of reinforcement) on the in service performance of components. This will result in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrating biology and behaviour for precision stratification of mental disorders' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In many areas of medicine, biomarkers have revolutionised diagnosis and personalised treatment allocation (‘precision medicine’). Psychiatry lags behind: disorders are still diagnosed by symptoms and no biomarkers have been found. However, addressing this is a formidable task because of a lack of analysis tools to understand the complex disruptions of mental disorders at multiple levels –from neurobiology to behaviour– and to tackle their extreme heterogeneity at every level. My vision is to provide a set of principled, next generation analysis tools to stratify mental disorders on the basis of biomarkers derived from population-scale neuroimaging and quantitative measures of behaviour from smartphone-based digital phenotyping.I will build generative models to chart variation in brain organisation across massive neuroimaging samples from more than 40,000 individuals based on ‘brain growth charting’ methodology I have pioneered. This will provide a universal platform to understand shared and distinct mechanisms of mental disorders at the level of the individual, simulate clinical brain states and test putative interventions using synthetic data. I will develop innovative machine learning tools to: (1) learn latent dynamics of digital phenotyping measures; (2) parse the dynamic interplay between brain systems and the behaviours they underpin; (3) integrate complementary information from distinct data modalities and (4) stratify mental disorders in a way that cuts across diagnostic classifications and accommodates different mechanisms converging on the same symptoms. These innovations will have far-reaching impact; here, I will showcase them by predicting trajectories of resilience and risk in major depression and bipolar disorder which are a leading cause of worldwide dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Aerial robotic platform for indoor safety and security' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Indoor robotics developed an autonomous platform for navigation and operation of robots indoors. Indoor Robotics, aims to provide a true answer to some of the most dangerous, time consuming and costly failures in the monitoring and physical security markets with an emphasis on creating a secure environment within a closed area. With this vision, we have developed Tando, a game-changing holistic solution to perform active monitoring of the premises. The core of the system is a patented highly crafted drone that docks on the ceiling and utilizes advanced sensors to perform routine surveillance (patrolling) and space monitoring. Tando will be the first responder to an anomaly and will allow for early detection of hazards such as fire and water leakages, which has the potential to decrease fatalities and insurance claims by 50%. Moreover, Indoor Robotics’ proprietary cloud-based Artificial Intelligence anomaly detection software provides further analysis of situations and events which gives the user insight into incidents. All in all, Tando goes beyond the state-of-the-art of monitoring and security systems offering advanced anomaly detection, higher coverage and faster response time at less than 25% the cost of current solutions.Autonomous and periodic security and safety checks have the potential to save lives, property and capital. As in many other markets, monotonous and repetitive actions that require advanced vision capabilities are better suited for robots. In contrast to current solutions (mostly based on fixed sensors), robots can reduce false alarms, increase coverage and perform active surveillance


**Keywords:** safety, fire prevention, preventive maintenance, risk prevention, damage mitigation, recurring monitoring,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Environmental and host factors in the risk of thyroid cancer' (1998-2002).

assistant: **Innovation**

The proposal is for the conduct of additional, complementary work to fully exploit the results of a large case-control study of thyroid cancer in young people, carried-out in Belarus and Russia after the Chernobyl accident. Because of the rarity of this disease in young people, this study provides a unique source of information on its aetiology. Two work packages are proposed:- WP1: Collection and critical analysis of information on past and current iodine deficiency and supplementation in the study areas- WP2: Detailed analyses of data on the roles of iodine deficiency and supplementation, history of thyroid disease, reproductive and dietary factors and genetic predisposition, and on their interactions, on the risk of thyroid cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pulsar Mode-changing And Polarization: mapping out a connected picture of neutron star evolution' (PulsarMAP) under Horizon Europe.

assistant: **Objectives**

Why is pulsar radio emission time-variable? How does the pulsar magnetic field evolve over its lifetime? The answers will change the landscape of fundamental physics, advancing our understanding of the universe’s most extreme environments and transforming the search for gravitational waves with pulsar timing arrays. Pulsars are spinning magnetized neutron stars emitting a beam of radio waves, and this radio beam is our direct observational link to an environment with some of the highest densities and gravitational field strengths imaginable. The key to answering those two questions is that they are connected: time-variability originates in the pulsar magnetosphere and is affected by the magnetic field. I will exploit this connection to understand neutron star evolution as a whole. I propose three work packages to map the evolution of neutron stars, capitalising on surveys, statistics and machine-learning. Their objectives, and the impact of the results, are as follows:1. GalaxyMap: I will prove or disprove the existence of compact anisotropic structures in the interstellar medium, transforming our knowledge of galactic structure and evolution.2. ModingMap: I will map out how mode-changing and nulling affect the pulsar population, radically advancing pulsar timing accuracy for gravitational wave searches.3. PopulationMap: I will capture the origins of radio pulsar time-variability in the magnetosphere by linking it to polarization, revolutionising our understanding of extreme neutron star physics, and the connection to magnetars and Fast Radio Bursts.I will address these objectives with my unique combined expertise in ISM physics, pulsar polarization and large-scale data science. I will apply my Partial Coherence model, develop new simulations to model the impact of scat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High Potency Dermatologicals' to be submitted under Seventh Framework.

assistant: **Abstract**

The HIPODERM application seeks support under the Marie Curie Industry-Academia Partnerships and Pathways scheme to facilitate the growth of a dynamic research team for 'the development of novel dermal-translocation, high-potency drug delivery systems'. Our aim is to develop a core scientific platform from which novel non-invasive drug delivery systems can be developed and clinically assessed. At the core of this project lies the hypothesis that microneedle assisted topical drug delivery has failed to fulfil expectations because researchers have routinely over estimated the scale of permeation enhancement possible using passive microneedle treatment and also, in general, have targeted unsuitable therapeutic molecules. This project aims to address both of these issues by developing new formulation and fabrication approaches. Combining physical disruption of the stratum corneum barrier with microneedle arrays and a number of active permeation enhancement techniques (such as iontophoresis and phonophoresis) will produce a range of novel hybrid permeation enhancement systems (HPES).  The project will focus on high potency therapeutics possessing low therapeutic concentrations that make only realistic demands on delivery systems. Such high potency materials are of increasing importance in therapeutics but are inherently difficult to work with because of the health and safety implications of their high activity. The project pools the expertise of a number of international partners with particular expertise in specific aspects of the approach.Three clinically interesting target areas have been identified for evaluation:1. Locally delivered chemotherapeutic agents for the treatment of cancers of the skin and underlying tissues2. Enhanced localised delivery of potent photosensiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Behavioral Based Forwarding' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

BEBA challenges a very ambitious goal: can we deploy wire-speed-reactive control/processing tasks inside the network switches, while retaining i) centralized control of their specification/operation, ii) high performance and scalability, and - crucial for real world adoption - iii) platform independency, i.e., consistency with the vendors’ need for closed platforms? BEBA’s answer revolves around the identification of a programming abstraction in the form of eXtended Finite State Machines (XFSMs). Via platform-agnostic XFSM “programs”, operators and enterprises will deploy not only static packet forwarding/processing rules (as in current OpenFlow devices), but will be able to specify and wire-speed enforce how such rules shall dynamically adapt to the time-varying flow and traffic behavior, i.e. in reaction to packet-level events, internal statistics changes, link/queue conditions, etc. BEBA holds the promise for future-proof, efficient, and easy to administer network devices capable to be repurposed so as to meet emerging needs. Indeed, BEBA’s approach, extended with node-level processing primitives made usable through our programming abstraction, brings about key benefits in the ability to i) “software-define” middlebox-type network functions well beyond static packet forwarding, with specific project’s attention to the monitoring and network security applications’ domains, and in the possibility to ii) address the current shortcomings revolving around the high latency and large overhead of centralized network control tasks. Finally, BEBA commits to a concrete and pragmatic innovation strategy. Short-time impact and standardization will be attempted by i) casting (part of) the BEBA approach as OpenFlow’s extensions; ii) making its implementation feasible over merchant-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Superconductivity in quantum-size regime' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Recent technological advances resulted in high-quality superconducting metallic nanofilms and nanowires being in the clean limit for the confined motion of electrons. Potential application of such nanostructures stimulated active research of their physical properties. These properties are mainly governed by the size-quantization of the transverse electron spectrum. This effect has a substantial impact on the basic superconducting characteristics, e.g., the order parameter, the critical temperature, the critical magnetic field and the critical current. This project focuses on theoretical description of various superconducting properties of nanostructures in the clean regime. The theoretical tools to perform this involve the formalism of numerical self-consistent Bogoliubov-de Gennes equations, the Eliashberg equations approach, Richardson exact solution of the discrete BCS model and the functional integration method. The study intends to clarify important question concerning the enhancement of the superconductivity due to quantum confinement and ways to optimize the targeted properties of superconducting structures. The results are expected to be of interest to a broad community of physicists working in the field of superconductivity as well as to technologies designing novel applications based on superconducting nanostructures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European joint Effort toward a Highly Productive Programming Environment for Heterogeneous Exascale Computing (EPEEC)' under Horizon 2020.

assistant: **Concept**

EPEEC’s main goal is to develop and deploy a production-ready parallel programming environment that turns upcoming overwhelmingly-heterogeneous exascale supercomputers into manageable platforms for domain application developers. The consortium will significantly advance and integrate existing state-of-the-art components based on European technology (programming models, runtime systems, and tools) with key features enabling 3 overarching objectives: high coding productivity, high performance, and energy awareness.An automatic generator of compiler directives will provide outstanding coding productivity from the very beginning of the application developing/porting process. Developers will be able to leverage either shared memory or distributed-shared memory programming flavours, and code in their preferred language: C, Fortran, or C++. EPEEC will ensure the composability and interoperability of its programming models and runtimes, which will incorporate specific features to handle data-intensive and extreme-data applications. Enhanced leading-edge performance tools will offer integral profiling, performance prediction, and visualisation of traces. Five applications representative of different relevant scientific domains will serve as part of a strong inter-disciplinary co-design approach and as technology demonstrators.EPEEC exploits results from past FET projects that led to the cutting-edge software components it builds upon, and pursues influencing the most relevant parallel programming standardisation bodies. The consortium is composed of European institutions and individuals with the highest expertise in their field, including not only leading research centres and universities but also SME/start-up companies, all of them recognised as high-tech innovators worldwide.