RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Epigenetic fine-tuning of T cells for improved adoptive cell therapy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Adoptive T cell therapy is a promising approach in various clinical settings, from target-specific immune reconstitution fighting cancer and chronic infections to combating undesired immune reactivity during auto-immunity and after organ transplantation.However, its clinical application is currently hampered by: 1) the acquisition of senescence during the required in vitro expansion phase of T cells which limits their survival and fitness after infusion into the patient, and 2) the functional plasticity of T cells, which is sensitive to the inflammatory environment they encounter after transfusion and which might result in a functional switch from the desired effect (e.g. immunosuppressive) to the opposite one (pro-inflammatory). I want to tackle these obstacles from a new molecular angle, utilizing the profound impact of epigenetic mechanisms on the senescence process as well as on the functional imprinting of T lymphocytes. Epigenetic players such as DNA methylation essentially contribute to T cell differentiation and harbor the unique prospect to imprint a stable developmental and functional state in the genomic structure of a cell, as we could recently show in our basic immune-epigenetic studies. Therefore, I here propose to equip T lymphocytes with the required properties for their successful and safe therapeutic application, including their functional fine-tuning according to the clinical need  by directed modifications of the epigenome ('Epi-tuning').To reach these goals I want: 1) to reveal strategies for the directed manipulation of the epigenetically-driven mechanism of cellular senescence and 2) to apply state-of-the-art CRISPR/Cas9-mediated epigenetic editing approaches for the imprinting of a desired functional state of therapeutic T cell products. These in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A european market place to link technology ventures and equity funding' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

To analyse the feasibility of a European initiative linking well-structured research-based business opportunities consisting as a promising new technology, a team, a business model and the needs for private funds - with the European investor community (banks, VC, business angels, industrial enterprises).Expected achievements are:- to provide an in-depth understanding of existing gaps in the evolution of research-based business opportunities from deal flow generation to investment, with a focus on technologies funded under Growth;- to identify the key process steps of a European market place of research-based business opportunities;- to propose concerted actions, with a clear European Added Value, which enhance the benefits of such European market place while taking account of the fragmented European economy and entrepreneurial culture;- to provide the European Commission with a set of recommendations regarding implementation of such concept within the 6th Framework Program.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Human infants' preparedness for relevance-guided learning through ostensive-referential communication' under Seventh Framework.

assistant: **Concept**

A recent hypothesis (the theory of 'natural pedagogy') proposes that an important function of human ostensive-referential communication is to allow the transmission of generic (semantic) knowledge to others. The primary potential beneficiaries of such a communication system are children, who are always novices with respect to the culture they are born into. This proposal aims to explore whether and how human infants are prepared to learn from adults through communication, what cognitive and neural systems support such learning process, and how this social learning process changes infants' perception, interpretation and representation of the world. Beyond traditional behavioural methods, we plan to use eye-tracking, electrophysiological (EEG, ERP) and optical imaging (NIRS) techniques to get insights about the online processes of perception, attention and memory during, as well as the understanding of the social and physical world through, non-verbal communication. In particular, we seek to track (1) the early development of sensitivity to various ostensive-communicative signals, (2) their relation to the understanding of referential deictic gestures, which is essential to be engaged in triadic communication, (3) how these signals modulate what infants pay attention to and preserve in their memory about objects, and (4) how the functional understanding of human-made cultural artefacts (such as tools) is affected by their demonstrated use in ostensive-referential communicative settings. The new framework theory of natural pedagogy will also provide a novel perspective to elucidate how further cognitive systems, such as the understanding of actions or causal relations, as well as the processes of imitation and word learning contribute to cultural learning by communication.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Targeted Action for Curing Trauma Induced Coagulopathy' (TACTIC) targeting Seventh Framework.

assistant: **Abstract**

Trauma remains one of the world’s biggest contributors to the global burden of disease. Predominantly affecting young adults and children, 800,000 European injury related deaths were recorded in 2002. Outcomes for critically injured trauma patients remain poor with severe bleeding, brain injury and tissue damage being associated with high mortality and disability. Nearly half of all trauma fatalities result from haemorrhage, with many patients developing a clotting disorder (coagulaopthy) within minutes of injury or during their clinical care, that worsens bleeding and hampers emergency surgery. Current treatment of bleeding and coagulopathy is based on empirical ”blind” administration of blood products, with large variations in practice between trauma centres.Important advances in care will only be made by a coordinated European national level approach that pulls discovery research into patients, into clinical guidelines and into national and global policy. “Targeted Action for Curing Trauma Induced Coagulopathy” (TACTIC) is a comprehensive programme of comparative clinical research that will deliver this quantum step in the global health care management of coagulopathic trauma patients, and potentially all patients with acute critical illness.TACTIC will recruit patients from a network of trauma centres in Amsterdam, Cologne, Copenhagen, London, Oslo and Oxford to compare the effectiveness of different current practices across Europe. It will deliver universal guidelines for how coagulaopathy should be monitored and treated, enabling the individualised treatment of all critically bleeding patients, and and resolve barriers to the subsequent continental implementation of patient-matched targeted transfusion policy, which is expected to reduce trauma haemorrhage-related
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Seals and Sealing Practices in Sasanian Iran: New Evidence from Taxt-e Solaymān' (TAXT).

assistant: **Innovation**

The subject of this application is the publication of an extraordinary collection of 824 Sasanian clay bullae bearing almost 2,000 seal impressions and inscriptions. The collection was recovered by Dr Yousef Moradi, the Experienced Researcher of this application, at the World Heritage site of Taxt-e Solaymān (Western Azerbaijan Province of Iran), the religious complex of Ādur Gušnasp, or ‘Fire of the Warriors’, in 2002–2008 during seven seasons of excavations conducted under the auspices of the Iranian Cultural Heritage Organization (ICHO). While most other Sasanian seals and sealings currently known are unprovenanced, the significance of this collection lies in the fact that it was recovered in a controlled archaeological excavation, with a specific provenance of the bullae. TAXT will produce the publication, both online and in print, of these bullae, and detailed studies of the seal impressions, including images and inscriptions, on the obverse. It will also provide a study of the impressions on the back-sides, or reverses, of the bullae. The reverses have small holes for the cord, and display cord marks and accidental traces of thumb and fingerprints of the persons handling the bullae when impressing the seals into the soft clay and when attaching the bullae to the objects which they were sealing. Moreover, there are imprints of the objects to which the bullae were attached, indicating that the objects were made of leather, grained parchment, and other materials. Coming from one of the three most sacred Zoroastrian fire temples of the Sasanian Empire (224–651 CE), TAXT will reveal unprecedented insights into the economic role of this Zoroastrian fire temple and its priesthood, generating findings that will be of interest to scholars from a variety of disciplines, inc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Role of cytosolic ascorbate-peroxidases (cAPXs) in heat stress (HS) perception and in systemic HS-signaling' (HS).

assistant: **Innovation**

The heat stress (HS) response is a highly conserved response characterized primarily by rapid induction of heat shock proteins (HSPs) and is regulated by heat shock transcription factors (Hsfs). The HS response is also closely associated with accumulation reactive oxygen species (ROS) and oxidative damage and acclimation of plants to elevated temperatures involves induction of activation of ROS scavenging enzymes in addition to activation of HSPs. Recently we have shown that ROS production and signals are required for the HS response in Arabidopsis, having a novel role in mediating systemic HS responses. Nevertheless, the role of ROS metabolism and signaling in HS-perception and HS-acclimation in plants is still poorly understood. Moreover, the role of ROS scavenging enzymes in HS-signaling and - acclimation is still largely unknown.  In this proposal, we will use Arabidopsis plants deficient in the HS-responsive cytosolic ascorbate peroxidases (cAPXs) to study the relationship between cytosolic H2O2 metabolism and systemic HS signaling, and explore the contribution of APX1, 2 and 6 to HS sensing and HS acclimation. Our long-term goal is to elucidate ROS-mediated systemic signaling events triggered by abiotic stress stimuli and identify genes and mechanisms that confer systemic acquired acclimation (SAA) to the stresses.Specific objectives1.Study the function of the cAPXs in the heat stress response Arabidopsis thaliana.2.Unravel the role of cytosolic H2O2 metabolism in systemic heat stress signaling.3.Use cAPX mutants to determine whether heat shock transcription factors (HsfA2 and HsfA4a) are direct sensors of ROS.Impact: The use of cAPX mutants as an experimental platform and our novel experimental approach would further advance the new field of systemic HS acclimati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Media, Science and Society: Governance and Engagement in Europe' in the context of a Sixth Framework call.

assistant: **Objectives**

The MESSENGER programme will develop the existing Guidelines on Science and Health Communication, produced in order to give them Europe-wide salience, provenance and acceptance. To ensure acceptance of the principles and methods to be embodied in the new Guidelines, substantial consultation will be undertaken with relevant stakeholders, actors and representatives of civil society organisations, as well as the science and technology communities. The European Guidelines will promote additional dialogue betwe en scientists and journalists, influence the way scientific advice is communicated through the media in Europe and stimulate EC-funded scientists to communicate the implications of their work to wider publics in understandable ways. Briefing and training m aterials for scientists will be produced that take into account the varying roles and styles of the media in EU member and candidate states. The Guidelines and associated documents will be relevant for inclusion in journalism education and training and th is role will actively be promoted. To aid these objectives additional materials will be provided in the form of support and briefing documents, teaching materials, etc. This mainstreaming activity will generate further cross-fertilisation between the Sci ence and Society programme and the ERA benchmarking activities, especially those related to the promotion of RTD culture, improved communication and public awareness of science. The primary methods to be employed combine analysis of science reporting in the media across EU member states with consultation involving a broad spectrum of civil society bodies and organisations. Such consultation will be designed to encourage greater degrees of informed participation by civil society in the development and ro ll-out of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SAFETYFANS: SAFEty and sustainabiliTY by design: a Framework for Advanced Nano-materials Synthesis.' (SAFETYFANS), addressing dissemination and exploitation.

assistant: **Impact**

"We synthesized a nanoform of novel functions! But, is it safe? Is it sustainable?""The Supervisors team in ISTEC-CNR (Host) synthesizes in their laboratory facilities new nanoforms (NF) with enhanced functionality. Their lab is a globally reputable center that over the years have established infrastructure and knowledge in developing novel nanoformulations. Everchanging, interactive, NF have a fate hard to track and policy makers, with precaution, limited NF use. However, valuable functionalities led to European initiatives to adopt the safety and sustainability by design (SSbD) concept, that ensures safety intervening at the design stage, avoiding later use uncertainties. But beyond concept, roadmaps are yet to be drawn and practices to be tried.The questions above are now addressed to the Researcher, who, during her PhD, predicted the toxicity of NF based on their physicochemical characteristics using Machine Learning (ML). The team will realize a central aspect of the SSbD concept: the design, development and validation of a framework that predicts safety, sustainability, and functionality at the synthesis stage of NF, based on previous knowledge, using ML. This framework allows in-silico testing impact on SSbD of changes in NF features without conducting the actual resource-consuming experiments. The endeavor is rooted on information digitization built on exploiting the Hosts industry and academia network and using its laboratory infrastructure to deploy real cases. The project unlocks NF applicability potential, proposes a pragmatic methodology on SSbD implementation and increases public confidence towards nanotechnology and ML. Multidisciplinarity and the Hosts extroversion will distinguish the Researcher in the growing market of scientific integrators as employe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Community-based development schemes for geothermal energy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

CROWDTHERMAL aims to empower the European public to directly participate in the development of geothermal projects with the help of alternative financing schemes (crowdfunding) and social engagement tools. In order to reach this goal, the project will first increase the transparency of geothermal projects and technologies by creating one to one links between geothermal actors and the public so that a Social Licence to Operate (SLO) could be obtained. This will be done by assessing the nature of public concerns for the different types of geothermal technologies, considering deep and shallow geothermal installations separately, as well as various hybrid and emerging technology solutions. CROWDTHERMAL will create a social acceptance model for geothermal energy that will be used as baseline in subsequent actions for inspiring public support for geothermal energy. Parallel and synergetic with this CROWDTHERMAL will work out details of alternative financing and risk mitigation options covering the different types of geothermal resources and various socio-geographical settings. The models will be developed and validated with the help of three Case Studies in Iceland, Hungary and Spain and with the help of a Trans-European survey conducted by EFG Third Parties. Based on these feedbacks, a developers’ toolbox will be created with the aim of promoting new geothermal projects in Europe supported by new forms of financing and investment risk mitigation schemes that will be designed to work hand in hand with current engineering and microeconomic best practices and conventional financial instruments.


**Keywords:** Geothermal energy, alternative finance, social engagement, social media, renewable energy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Long time-series undersea surveillance' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The LOTUS project consists of 2 years at Scripps Institution of Oceanography and 1 year at Oceanlab, University of Aberdeen.The objectives of the study are to evaluate the use of long-term and permanent monitoring platforms in the deep-sea, and to use the data provided in basic studies of deep-sea animal biology. Novel techniques will include the use of an autonomous bottom-crawling rover" vehicle to measure benthic parameters and dock with an undersea network, and the installation of a fixed camera and se dimentation monitoring station. Each phase of the study will be preceded by detailed studies of animal distribution, behaviour, sedimentation rate and quality, benthic metabolism, and flow regime across the wider region of the proposed monitoring sites. Th ese data willallow suitable sites to be chosen for permanent monitoring, put the outputs of the fixed stations into context, and determine how reliable the conclusions drawn will be. A programme of experiments both in the Pacific and at contrasting Europea n sites will investigate the importance of food supply from the surface and from chemosynthetic communities in controlling the behaviour, distribution, and activity of deep-ocean animals. The detail and quality of the data available during LOTUS is likely to allow these studies to make a major and fundamental impact on this field. LOTUS will provide a pilot study for the implementation of ocean monitoring in the EU. This capability is currently lacking within Europe, risking environmental damage and placing European scientists and marine industries at a competitive disadvantage."