RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Targeting potential of carbon nanotubes at the blood brain barrier' (CNTBBB) targeting Seventh Framework.

assistant: **Abstract**

Targeted drug delivery across the blood brain barrier (BBB) to the central nervous system is a large challenge for the treatment of neurological disorders. This 4 year ERC program is aimed towards the evaluating the BBB penetration capacity and toxicological potential of novel carbon nanotube (CNT) carriers using an integrated multidisciplinary approach. State-of-art characterisation techniques developed by the PI will be applied and further developed to detect the interaction of carbon nanotubes with in vitro BBB model and neuronal cells. Specific aims:1.Identify the mechanisms of translocation of CNT across the endothelial cells which comprise the BBB, as well as uptake by neuronal cells in vitro.2.To investigate the effect of length, diameter and surface charge of CNTs on the BBB and neuronal cells penetration capacity in vitro.3.To investigate the toxicological profile of CNT on the BBB and the various neuronal cell types (immortalised and primary neuronal cultures).4.Develop protocols to assess whether the CNTs degrade inside the cell.The ERC Grant will consolidate the new Research Group in nanomaterials-cell interfaces, and allow them to perform stimulating investigator-initiated frontier research in nanotoxicology and nanomedicine. To this end, a multi-disciplinary laboratory will be realized within the framework of this 4-year the ERC Programme. This will permit the group around the PI, to expand activities, push limits, create new boundaries, and develop new protocols for studying nanoparticle-cell interactions in close collaboration with ICL s Department of medicine and chemistry. Within the proposed program there is an underlying ambition both to gain a fundamental understanding for which parameters of CNTs determine their penetration capacity through the BBB
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Magnetic resonance imaging of wood and its interface with glue, coatings and air' (MARWINGCA) targeting Fifth Framework.

assistant: **Abstract**

Wood is a sustainable, renewable, versatile material. When processed, dried and protected correctly it becomes a high quality stable material. The increasing use of environmentally friendly coatings can cause problems with rot in wood panels due to water retention in the coating/wood interface. Moisture ingress into glue can lead to mechanical failure. This project utilises recent advances in magnetic resonance imaging techniques, which allows visualisation of the moisture content in wood at its interface with air, coatings and glue. Moisture profiles in untreated, glued and coated wood drying and dehydration will be measured. A surface layer-drying model will improve electrical impedance moisture sensors used in kiln drying control. Quantitative measurements of coatings and glues as a function of composition assist the development of improved products. Through an understanding of wood properties we gain both economic and environmental benefits.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'SILKNOW. Silk heritage in the Knowledge Society: from punched cards to big data, deep learning and visual / tangible simulations'.

assistant: **Objectives**

Silk was a major factor for progress in Europe, mostly along the Western Silk Road’s network of production and market centres. Silk trade also allowed for exchange of ideas and innovations. Punched cards were first used in Jacquard silk looms, long before modern computers were even imagined. Today, too, fashion and high-end textile industries have a huge impact in the EU, reaching €525 billion in annual turnover. Silk, however, has become a seriously endangered heritage. Although many European specialized museums are devoted to its preservation, they usually lack size and resources to establish networks or connections with other collections. SILKNOW aims to produce an intelligent computational system that goes beyond current technologies in order to improve our understanding of European silk heritage. This legacy will be studied, showcased and preserved through the digital modelling of its weaving techniques (a “Virtual Loom”). Users will access the resulting information through visual and tangible simulations, and experience vastly enhanced search tools, providing better results through automatic visual recognition, advanced spatio-temporal visualization, multilingual and semantically enriched access to existing digital data. Thus, SILKNOW will improve the understanding of EU heritage and its rich diversity, applying next-generation ICT research to the needs of various users (museums, education, tourism, creative industries, media…), and preserving an intangible heritage (ancient weaving techniques) for younger generations. Its research activities and outputs will have direct impact in computer science and big data management, focusing on searching digital content in heterogeneous, multilingual and multimodal databases. SILKNOW will be possible only with the close coop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Maintaining neurotransmission: clathrin-mediated endocytosis and kiss-and-run' in the context of a Sixth Framework call.

assistant: **Objectives**

Our brain consists of over a 100 billion neurons, organized into neuronal circuits transmitting electrical pulses. Hence, the integrity of a circuit depends on reliable neuronal communication: if a neuron fails, the circuit fails. The importance to maintain neuronal communication is underscored by numerous psychiatric disorders, such as schizophrenia, epilepsy and drug addiction arising from defects in specific circuits. Neurons in these circuits communicate by releasing neurotransmitters from synaptic vesicles and to maintain communication neurons dependent on efficient recycling of synaptic vesicle pools. The work focuses on understanding mechanisms of vesicle recycling using morphological and functional assays. The studies indicate the existence of 2 recycling pathways: clathrin-mediated endocytosis (CME), where membranes invaginate to form vesicles, and kiss-and-run, where vesicles form a transient fusion pore and recycle locally. While many components of CME are identified and shown to interact biochemically, few are analysed in vivo.CME will be studied using functional analyses of newly identified genes as well as by using novel imaging strategies involving FRET, allowing to visualize protein interactions while vesicles form in real-time, revealing nov el types of synaptic plasticity. The existence of alternative vesicle recycling modes, like kiss-and-run, remains controversial, because no specific protein required for it has been identified. The group found that when CME is blocked in endophilin and synaptojan in mutants some transmission akin to kiss-and-run persists.Based on this a genetic strategy to isolate the first molecular components of kiss-and-run, paving the way towards better understanding of the process is outlined. Taken together, the work seeks to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chemical Space for Antimicrobials on a Peptide Basis' (SPACE4AMPS) targeting Horizon 2020.

assistant: **Abstract**

Multidrug resistant (MDR) bacteria represent a global public health threat against which new drugs are urgently needed. Antimicrobial peptides (AMPs), mostly derived from naturally occurring linear or cyclic peptides, can contribute to solving the problem. AMPs are already in clinical use, do not easily lead to resistance, and can rely on a strong manufacturing sector and established protocols for clinical development. However, most AMPs are degraded by proteases and have poor pharmacokinetics.SPACE4AMPS aims to identify new AMPs with diverse peptide chain topologies and building blocks and with the following characteristics: i) Broad activity spectrum, ii) High activity, iii) Low probability for induced resistance, iv) Low proteolysis, v) Better pharmacokinetics.To reach its goal SPACE4AMPS will create computational tools to explore the extremely vast chemical space of large molecules such as peptides and natural products, which now lies within reach of the latest computer hardware developments. To better understand antimicrobial drugs, we will design a molecular fingerprint relating antimicrobial activity to molecular structure and use it to draw a tree-map of the antimicrobial chemical space. We will enrich this map with new compounds from generative models using neural networks. To identify new AMPs, we will use a genetic algorithm carrying out cycles of molecule generation and similarity calculations to select cyclic peptides and peptide dendrimers including lipidated, peptoid (N-alkyl glycines) and N-methylated residues, synthesize and test these molecules against MDR bacteria, fungi and parasites, screen actives for toxicity, and study their structure and mode of action. By its ground-breaking and unprecedented computational/synthetic/biological approach, SPACE4A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Critical Race and Intersectional Theory In (Comparative) Criminal Law' (Comparative).

assistant: **Innovation**

The CRITICL (Critical Race and Intersectional Theory In (Comparative) Criminal Law) Project proposes to undertake an interdisciplinary European study of hidden biases and veiled discrimination in criminal justice, through the lens of critical race theory and intersectionality. Criminal law, like all legal disciplines, has long assumed a “universality” of function: that the law itself is neutral, capable of equal and indiscriminate application. Lady Justice, blindfolded and impartial, is figurative example, while the work of the European Union assumes neutrality as a key factor to promote integration. Yet, as Critical Race and Intersectional Theories (“CRIT”) show, the law itself may entrench and reinforce structures of subordination, inferiority and discrimination against particular (especially, minority and vulnerable) groups. Likewise, while modern legal systems may recognise different grounds for discrimination, such as race, gender, religion, ethnicity, sexual orientation, age, disability and neurodiversity, these are based on the social and historical processes that have shaped the constitutional traditions of each country. To date, however, neither CRIT nor discrimination within the criminal law have received much attention in either European or comparative legal scholarship. Through an analysis of procedural rights, CRITICL intends to fill this lacuna, both in the context of criminal law, and by adapting CRIT to the European (EU) (procedural right) context, through proffering European and national policy recommendations and guidelines by which the law’s current procedural rights inequalities can be eliminated.


**Keywords:** defence rights, right to a fair trial, criminal justice, critical race theory, intersectionality, procedural rights, legal inequality, hidd
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Chemo-Enzymatic Manufacturing Routes to High- Value compounds' under Horizon 2020.

assistant: **Concept**

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop a platform of “green” chemoenzymatic methods for the production of high value active pharmaceutical ingredients –  both those currently on the market, and those in development pipelines of the Pharma industry.  The partners will exemplify the use of the platform through its application in the production of 4 drugs currently on the market – namely Duloxetine, Atomexetine, Ramosetron and Paricalcitol.In order to achieve this objective the proposal brings together 3 partners with complementary skills:Kelada Pharmachem: Phase transfer catalysis/organo catalysis/scale-up  of chemical processesCerbios Pharma: Biocatalysis and fermentation methodologies for drug productionIC-CNR: Protein crystallography and enzymatic engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Clinical, genetical and functional analysis of peripheral neuropathies: an integrated approach'.

assistant: **Concept**

The hereditary motor and sensory neuropathies (HMSN) are a clinically heterogeneous group of peripheral neuropathies with an overall prevalence of 1 in 10.000. Charcot-Marie-Tooth disease (CMT) is the most common form of HMSN and has a frequency of 1 in 2500 in Europe. CMT is a heterogeneous disease studied extensively in different research areas such as neurology, neuropathology, neurobiology and genetics. Other forms of HMSN and related disorders, such as the hereditary neuropathy with liability to pressure palsies (HNPP) and distal hereditary motor neuropathy (distal HMN) or spinal CMT are being studied. The objective of this BIOMED2 concerted action is to encourage collaboration between 59 laboratories in 17 European countries, working in the field of CMT and related peripheral neuropathies, bringing together their expertise to find solutions to the different research areas. The concerted action will be coordinated by the Programme Co-ordinator in conjunction with the steering group. The various activities will be carried out by the European research teams in order to achieve the defined objectives and targets. The leader will centralize the data obtained in the research field and disseminate the information and results. The aims of the European HMSN consortium group can be summarized as: transfer of research and diagnostic information between the members of the consortium, efficient distribution of genetic material, introduction of new methods for research and diagnostic purposes, solving problems and discussing results during annual meetings of the consortium group via oral presentations and/or poster sessions at the site of the European Society of Human Genetics or the European Society of Neurology, organisation of topic specific workshops by sub-committees, mobi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Evaluation of the efficacy and of the antiviral activity of T-705 (favipiravir) during Ebola virus infection in non-human primates  humans'.

assistant: **Concept**

The ongoing Ebola outbreak in West Africa is the largest and deadliest the world has ever seen. In September 2014, the number of EBOV cases exceeded the total of all cases from previous known outbreaks. Further, this public health crisis shifted into a complex emergency, with significant, social, economic, humanitarian, political and security dimensions. Till date, no effective medicine has been proven to be effective against EBOV. As a result, it is immensely difficult to mitigate the current outbreak as well as prevent further outbreaks in this region. On Sept 4-5 2014, the WHO gathered expertise on experimental therapies and vaccines and their role in containing the Ebola outbreak in West Africa. During this consultation, experts identified several therapeutic and vaccine interventions that should be the focus of priority evaluation. Among these candidates is the existing antiviral drug Favipiravir, that has proven activity against many RNA viruses in vivo and in vitro including Ebola. Favipiravir is known to inhibit viral gene replication within infected cells to prevent propagation among which it inhibits viral gene replication within infected cells to prevent propagation. Hence, Favipiravir is currently aimed  as a curative option in severe pandemic flue. Furthermore, there is currently enough stock of Favipiravir to even treat more than 20.000 patients, and the producer of Favipiravir, Toyoma Chemical/Fujifilm in Japan is willing to rapidly upscale the production of this drug. This drug has been extensively tested in humans and approved in Japan for treatment and prevention of influenza. The drug has shown an excellent safety profile in more than 2000 patients tested and no major adverse effect were reported. The current crisis requires both an immediate response
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TWINNING FOR SOLAR ENERGY-DRIVEN SURFACE ENGINEERING OF METALLIC PARTS' under Horizon Europe.

assistant: **Concept**

TWINSOLARSURF’s overall aim is to improve the knowledge, skills, competencies and innovation capacities of the research and administrative staff of the Laboratory of Surface Engineering (Triblab) of the Department of Mechanical Engineering, University of West Attica (UNI.W.A), Greece. The strategic target is the evolution of Triblab from a laboratory of a former technological institute to a unique in Greece, future-oriented research unit of an engineering school, strategically conceived as a self-sustained contact mechanics facility and eventually established as a reliable research partner for academia and industry at European level of innovation. In this perspective and in conjunction with EU and Greece’s transition into a carbon neutral economy by 2050, Triblab has partnered with two top-class EU Research Institutes, namely the Institute of Future Fuels of the German Aerospace Center/DLR and the Spanish CIEMAT-Plataforma Solar de Almeria. The consortium will work together on a strategic plan for co-developing a capacity building programme, sharing knowledge, integrating expertise and skills of institutes during and towards their transformation and evolution and delving into new research avenues. This endeavour will run in parallel with an exploratory project on the research playground of surface processing of metallic materials for use in aggressive environments (e.g. wear, abrasion, erosion, high temperature), via exploitation of solar energy, in an ambitious, yet pragmatic and feasible workplan based on previous relevant research efforts of the partners. The overall approach is fully linked to the European Green Deal strategy for green industrial technologies of the future, further penetration of renewable energies and building the skilled research personnel capable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Skill Acquisition in Humans and Robots' (SAHR), addressing dissemination and exploitation.

assistant: **Impact**

Society is rapidly opening its doors to robots in our daily life with autonomous vehicles, rehabilitation devices and autonomous appliances. These robots will face unexpected changes in their environment, to which they will have to react immediately and appropriately. Even though robots exceed largely humans’ precision and speed of computation, they are far from matching humans’ capacity to adapt rapidly to unexpected changes. In the past decades, robotics has made leaps forward in the design of increasingly complex robotic platforms to meet these challenges. In this endeavour, it has benefited from advances in optimization for solving high-dimensional constrained problems and in machine learning (ML) to analyse vast amounts of data. These methods are powerful for planning in slow-paced tasks and when the environment is known. This project addresses a growing need for methods that show fast and on-line reactivity. We design controllers that can plan at run time and adapt to new environmental constraints. We offer a novel approach to robot learning that follows stages of skill acquisition in humans. To inform modelling, we conduct a longitudinal study of the acquisition of dexterous bimanual skills in craftsmanship. We study how humans exploit task uncertainty to overcome their sensory-motor noise, and how humans learn bimanual synergies to reduce the control variables. This study informs the design of novel learning strategies for robots that exploit failures as much as successes. We combine planning and ML to learn feasible control laws, retrievable at run time with no need for further optimization. We exploit properties of dynamical systems (DS), which have received little attention in robot control, and use ML to identify characteristics of DS, in ways that were not