RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanoparticle-based immunization, a novel therapeutic strategy for amyotrophic lateral sclerosis' (NanoALS).

assistant: **Innovation**

As the life span of the population extends, the prevalence of neurodegenerative diseases is rapidly increasing representing a considerable impact for the quality of life and economy of many countries worldwide. Most of these diseases, including Amyotrophic lateral sclerosis (ALS) are currently considered as proteopathies, where some proteins (SOD1 in the case of ALS) adopt misfolded conformations prone to aggregate and cause cellular toxicity and motor neuron death. Moreover, these proteins are secreted to extracellular media contributing to the widespread of the disease in a prion-like manner, by acting as scaffolds for the misfolding of endogenous proteins when uptaken by surrounding cells. The aim of NanoALS is to bring together Neuro and Nanoscience fields to design a novel passive immunization therapy to target the misfolded SOD1 released into cerebrospinal fluid in ALS. It will be based on the systemic delivery of gold and PLGA nanoparticles functionalized with specific antibodies against the different isoforms of misfolded SOD1. These nanoconstructs will bind the different aberrantly folded SOD1 forms preventing their reuptake by neighbouring cells and blocking the cytotoxic epitopes exposed after misfolding. The multidisciplinary work program in NanoALS covers the synthesis of the functionalized nanoconstructs as well as validation of their therapeutic potential in neuronal cell lines and in the SOD1-G93A mouse model of ALS. Immunization against misfolded extracellular proteins has showed an encouraging success in ALS mouse models and in recent clinical trials with Alzheimer patients. Optimizing the delivery systems and targeting different misfolded isoforms as well as the active exploitation and dissemination strategy designed for NanoALS will maximize the bene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Restriction of the Fourier transform with applications to the Schrödinger and wave equations' (RESTRICTION) targeting Seventh Framework.

assistant: **Abstract**

In 1967, Stein proved that the Fourier transform of functions in L^p could be meaningfully restricted to the sphere for certain p>1. The restriction conjecture, which asserts the maximal range of such p, was solved by Fefferman in two dimensions, but the conjecture remains open in higher dimensions. Strichartz considered the same question but with the sphere replaced by the paraboloid or the cone, and a great deal of progress has been made in the last two decades by Bourgain, Wolff and Tao, among others. Due to the fact that the adjoint operators of the restriction operators to the paraboloid and cone correspond to the Schrödinger and wave evolution operators, respectively, this work has been hugely influential. The main goal of this proposal is to improve the state of the art for the mixed norm analogues of these conjectures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mortality Risk Attributable to Thermal Discomfort Indicators with Implications of Climate Change' to be submitted under Horizon 2020.

assistant: **Abstract**

A rapidly growing body of studies attribute mortality outcomes to thermal exposures, by empirically estimating reduced-form mortality responses to meteorological fields, usually ambient temperature. The research theme proposed in this project is motivated by the awareness that the human thermoregulatory system is a function of not just ambient temperature, but also other environmental parameters such as humidity, radiant temperature and wind. Correct characterization of the environment-related mortality relationship is vital not just in epidemiology, but also for climate-health impacts assessment, understanding the burden on health services, and the potential spill overs to labour productivity and the wider economy. This project will attribute mortality risk to multiple thermal stressors not previously examined in epidemiology and the wider climate-health impacts studies. The project will apply innovative approaches and for the first time, a comprehensive suite of thermal discomfort indicators, both under present climate and contrasting future socio-economic/climate scenarios. The transdisciplinary nature of the project requiring knowledge and training in subjects such as biostatistics, environmental epidemiology, human biometeorology, big data and climate modelling; will involve two-way transfer of knowledge between the researcher and the host institute. Results have the potential to: (i) improve the data and modelling approaches applied in existing environment-related morality studies at a global scale; (ii) facilitate better understanding of the population’s adaptive capacity to thermal exposures, accounting for age and gender; (iii) inform future public health responses at various national/international scales, such as urban planning, healthcare services, and invest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Novel highly sensitive NanoWire sensors for disease biomarker analysis'.

assistant: **Concept**

Nanowire-based platforms are expected to radically impact disease diagnosis and precision medicine thanks to their high surface-area-to-footprint ratio and optical waveguiding properties. The challenge is to cost-effectively produce nanowires in a reproducible manner. At Aligned Bio, we have developed a new technology that enables, for the first time, mass- and cost-effective production of nanowire sensors. Our solution relies on three core patented technologies, which when combined, allow to produce low-cost, high-quality nanowires with controlled diameters to reproducibly enhance waveguiding properties of nanowire platforms. This unique combination of novel technologies results in enhanced biomarker detection platform devices with 20 times higher sensitivity than current solutions in the market and, crucially, at low price. To effectively carry out the tasks needed to reach TRL9, the EIC Accelerator project is crucial to bridging the critical risk-gap.


**Keywords:** Diagnostic tools,Medical devices,Immunology,Semiconductors,process engineering,Production technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Generation of a genetic body map for Atlantic Salmon' in the context of a Fourth Framework call.

assistant: **Objectives**

To isolate and identify new genes from Atlantic salmon using a strategy based on cloning expressed sequence tags (ESTs).Messenger RNA (mRNA) will be prepared from nine adult salmon tissues (i.e. male and female gonad, liver, spleen, kidney, intestine, gill, brain, muscle) and used to generate cDNA libraries. Other tissues from salmon challenged with pathogens and salmon that are immuno-stimulated will also be included. Clones will be selected representing the abundant and rare mRNA transcripts in each library and 400-600 bp of their DNA sequence will be elucidated. Between 500 and 1000 ESTs will be determined from each tissue, resulting in a detailed identification of the genes that are transcriptionally active in each chosen tissue. Selected ESTs (a minimum of 50 per partner), representing the most abundant mRNAs in each respective tissue and mRNAs of particular interest based on homology searches in the international databases, will be tested for their tissue specific expression patterns among other salmon tissues.RESEARCH TASKSThe SALGENE partners will prepare poly(A) messenger RNA (mRNA) from the chosen salmon tissues and construct complementary DNA (cDNA) libraries using molecular genetic methods. Following this, the partners will determine partial DNA sequences of between 500 and 1000 clones from each of the eight selected salmon tissues, which will be termed expressed sequence tags (ESTs). Homology searches will be performed between the salmon ESTs and DNA sequences deposited in the international DNA databases to identify as many salmon ESTs as genes as proves possible. The SALGENE partners will also perform tissue expression analysis on selected ESTs of interest to determine tissue expression profile data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Integrating and managing services for the European Open Science Cloud'.

assistant: **Objectives**

The EOSC-hub project creates the integration and management system of the future European Open Science Cloud that delivers a catalogue of services, software and data from the EGI Federation, EUDAT CDI, INDIGO-DataCloud and major research e-infrastructures. This integration and management system (the Hub) builds on mature processes, policies and tools from the leading European federated e-Infrastructures to cover the whole life-cycle of services, from planning to delivery. The Hub aggregates services from local, regional and national e-Infrastructures in Europe, Africa, Asia, Canada and South America. The Hub acts as a single contact point for researchers and innovators to discover, access, use and reuse a broad spectrum of resources for advanced data-driven research. Through the virtual access mechanism, more scientific communities and users have access to services supporting their scientific discovery and collaboration across disciplinary and geographical boundaries.The project also improves skills and knowledge among researchers and service operators by delivering specialised trainings and by establishing competence centres to co-create solutions with the users. In the area of engagement with the private sector, the project creates a Joint Digital Innovation Hub that stimulates an ecosystem of industry/SMEs, service providers and researchers to support business pilots, market take-up and commercial boost strategies.EOSC-hub builds on existing technology already at TRL 8 and addresses the need for interoperability by promoting the adoption of open standards and protocols. By mobilizing e-Infrastructures comprising more than 300 data centres worldwide and 18 pan-European infrastructures, this project is a ground-breaking milestone for the implementation of the European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'COmplex media and METasurfaces for scalable and efficient photonic neural networks' to be submitted under Horizon Europe.

assistant: **Abstract**

With the advent of large language models (e.g. ChatGPT), the use of artificial neural networks has become ubiquitous in our society. However, the energy consumption is currently doubling every two months, leading to an unsustainable growth. This is primarily caused by the extensive interconnectivity that characterizes neural networks’ hardware architecture, which are notably challenging and power-consuming to implement in electronics. Photonics offers a promising solution, enabling faster operations with significantly reduced energy consumption. Fully-connected layers are already available in several photonic platforms, including complex media, one of the applicant’s main areas of expertise. However, optics still lacks a fundamental building block for implementing neural networks with advanced learning capabilities: a nonlinear activation layer that is non-polynomial and able to cascade its signal to subsequent layers. This MSCA PF will focus on developing a thermo-optically reconfigurable nonlinear metasurface, designed to implement such nonlinear activation layer. With this innovative device, the COMET project will demonstrate that the combination of COmplex media and METasurfaces can provide a scalable, computationally powerful and efficient photonic neural network.The project will be conducted at Politecnico di Milano with Prof. Michele Celebrano, expert in nonlinear optics and metasurfaces. It will also include a secondment at Sorbonne Université, in Prof. Sylvain Gigan’s group, which specializes in complex media and their applications in photonic computing. The combined expertise of the applicant and the two host institutions will ensure that CoMet makes its unique contribution to the development of more efficient next-generation AI.The scientific excellence of Co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Translating rewards to eye movements'.

assistant: **Innovation**

The drive for rewards controls almost every aspect of our behavior, from stereotypic reflexive behaviors to complex voluntary action. It is therefore not surprising that the symptoms of neurological disorders that interrupt reward processing, such as those stemming from drug-abuse and depression, include deficits in the capacity to make even simple movements. Accordingly, how do rewards drive and shape movements? The brain uses two major subcortical networks to drive behavior: the basal ganglia and the cerebellum. Both areas are essential for the control of movement as damage to either structure leads to severe motor disabilities. Research on the basal ganglia has highlighted their importance in the control of reward-driven behavior-but how the reward information interacts with sensorimotor signals to drive the motor periphery is unknown. By contrast, research on the cerebellum has focused primarily on how sensory error signals are used to optimize motor commands but has mostly ignored the modulatory factors that influence behavior, such as reward. My goal is to unify research on the basal ganglia and cerebellum in order to understand how the computations underlying the influence of reward on action are implemented in the brain. I hypothesize that rewards drive and shape the motor commands in both subcortical networks, albeit with differing behavioral functions. While in the basal ganglia, information about reward is used to mediate selection between multiple actions; I predict that, in the cerebellum, reward potentiates movements to drive more accurate behavior. I will use the monkey smooth pursuit eye movement system as a powerful model motor system to study the neural mechanisms by which reward influences motor processing. I will combine the use of novel behavioral p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Removing non-CO2 greenhouse gas emissions to support ambitious climate transitions'.

assistant: **Innovation**

Non-CO2 greenhouse gases are responsible for 28% of total anthropogenic emissions, of which CH4 (16%) and N2O (6%) are major contributors. These gases are hard to abate due to their diverse and inherently distributed sources (with concentration <1%-vol), for example the agricultural sector (livestock and farming), which is the main source of anthropogenic CH4 emissions. Moreover, their very low concentrations in the atmosphere (ppb or ppm level) make the recovery particularly challenging. However, mitigating these gases can significantly accelerate the transition towards a net-zero greenhouse gas EU economy by 2050, and achieve sustainable negative emissions thereafter. In this context, REPAIR will develop first-of-its kind technological proof of concept to remove non-CO2 gases like CH4 and N2O from diluted sources, including from the atmosphere. Two process routes are proposed: (i) capture, concentration and storage/conversion (ii) direct catalytic conversion. The proposed processes can be easily integrated with direct air capture and storage and/or use of CO2, thereby removing multiple greenhouse gases (CH4, N2O and CO2) in a single system with lower energy and cost. The potential of the technologies developed in the REPAIR project will be evaluated through (i) techno-economic analysis (ii) scenario-based assessment to evaluate impact on climate (iii) impact case studies in agricultural and farming sector. Results will enable making decisions about upscaling of the technology in agricultural farms by 2035 in addition to increasing knowledge about plausibility of removing non-CO2 gases from diluted sources. It will also help the European Commission to make informed decisions about regulations for non-CO2 greenhouse gas emissions from 2030 as indicated in the ""Fit for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European joint conferences on theory and practice of software 2003 - support for young researchers' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The ETAPS ConferencesETAPS is an open confederation of 5 main annual conferences (FOSSACS, FASE, ESOP, CC, TACAS), accompanied by a number of satellite workshops (10 planned for 2003) and other events (tutorials, project and working group meetings, etc). The series started in 1998 in Lisbon, based on the earlier tradition of the individual conferences, and through the subsequent events in Amsterdam, Berlin, Genova and Grenoble (forthcoming in 2002) has built its position as a popular annual meeting acting as a strong focus point for academic and industrial researchers working on topics related to Software Science.The events that comprise ETAPS 2003 will address various aspects of the system development process, including specification, design, implementation, analysis and improvement. The languages, formalisms, methodologies and tools to support these activities are all well within its scope. Different kinds of theory and practice will be presented, with an inclination toward theory with a practical motivation on one hand and soundly based practice on the other hand. Many of the issues involved in software design apply to systems in general (including hardware systems) and the emphasis on software is not intended to be exclusive. The initial set of events outlined below illustrate only part of the intended scope of ETAPS 2003.Each conference retains its own identity, with a separate programme committee selecting presentation in a competitive procedure and independent proceedings (separate LNCS volumes). Events run in parallel to a large extent, with a degree of coordination between programme chairpersons and local organizers ensuring a coherent schedule.The conferences and satellite events fall under one of the following main themes (relevant for all four IST key action
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Experimental verification of the mechanisms of shock waves acceleration of volcanic particles toward metal targets: a tool to understand shock waves hazard in explosive volcanic eruptions' (SPAEX), addressing dissemination and exploitation.

assistant: **Impact**

Despite shock waves commonly occur during explosive volcanic eruptions, a number of issues concerning their generation and propagation is still object of debate in the scientific community and the associated hazard is downplayed in the risk assessment of active volcanic areas. Micrometric impact craters produced by volcanic ash particles were found on a steel basketball pole in one of the villages destroyed by the 1982 eruption of El Chichón volcano (Mexico). The velocities of impacts, calculated by analytical methods, showed typical shock waves values up to 980 m/s. The research topic outlined in this proposal is the experimental acceleration of volcanic particles of different size and mass toward steel targets by shock waves produced by a rapid decompression of a pressurized system (fragmentation bomb). Research questions to be answered are: a) which is the role of the gas phase in accelerating particles by the rapid expansion produced by a shock wave? b) Which is the role of particles’ size and/or mass in the acceleration mechanism? c) What is the importance of the impact angle in the magnitude of the craters produced? The results expected will contribute to a better understanding of the mechanisms of shock waves propagation during explosive eruptions and inspire further investigations to improve hazard mitigation strategies.