RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SUSPension ENvironment for CEll culture' (SUSPENCE), addressing dissemination and exploitation.

assistant: **Impact**

Large-scale production of cells is essential for basic research, disease modelling and drug testing. However, scalability and standardization in cellular manufacturing are still major challenges: when large numbers of cells are required, conventional two-dimensional (2D) culture strategies, mainly based on manual, space- and labour-intensive interventions, are practically and financially unsustainable. Dynamic suspension allows large-scale production of cells, but current solutions on the market suffer from limitations in terms of cells damaging and potential contamination (stirred tank bioreactors) or high cost and complexity (rotating bioreactors). The SUSPENCE solution is a microgravity perfusion bioreactor, a highly innovative technological system that keeps cells in suspension in the culture chamber, allowing them to grow and reach maturity in dynamic conditions with no rotation mechanism or moving parts. SUSPENCE benefits have been confirmed by explanatory morphological and biological tests carried out on an in vitro cell culture. SUSPENCE advantages on competing solutions are: less cell damage, more easy-to-use, increased productivity, better monitoring and control and reduced operation costs. The design of SUSPENCE bioreactor is protected by an international patent application. The target users are research labs and red-biotech firms and; the market size has been estimated in over 6.000 potential customers in EU. Commercialization will start on the Italian market in 20 months from the start of the project, after pre-commercial pilots and industrialization, to expand on the EU market in 36 months and to reach the global market in month 48, after release of larger capacity devices. Forecast revenues are 9 M€/year in the 3rd year of commercialisation. The total fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of an automatic hot and cold food vending machine and associated packaging.' in the context of a Fifth Framework call.

assistant: **Objectives**

The project embraces a unique concept in vending foods automatically in hot and chilled forms from deep frozen in less than fifty seconds using a novel system of moving food from a deep freeze storage area in the machine to the consumer via custom built microwave ovens. The purpose of the research into enhances the performance of both the machine and the packaging as follows. Achieve heating and dispensing on a level plane to enable recipes incorporating sauces to be added to the food menus. Install modems and write software to adjust oven heat times, monitor food temperature, and log machine performance parameters and stock levels remotely via digital telecommunications. Install a consumer purchasing system via mobile telephones. Replace chipboard cartons with recycled PET trays incorporating anodal suspected film lining.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Epigenetic regulation of the adaptative response of C.reinhardtii to development and environmental stresses:Characterization of .Histone PTMS,gene regulation and pathways employing a Systems Biology' in the context of a Seventh Framework call.

assistant: **Objectives**

Reversible modifications of DNA sequence and histones serve as a fast and accurate process to regulate gene expression. These mechanisms act specifically and co-ordinately, constituting what is called the epigenetic code, and influence a multitude of cellular processes including, besides the regulation of the transcription, differentiation, DNA replication, repair or imprinting, among others. Aided by the use of multidisciplinary combination of new technologies such as epigenomics, transcriptomics, proteomics, metabolomics and bioinformatics “EpiSysBiol” is expected to precisely identify the epigenetic changes and the variations in the proteome and metabolome that may regulate upon stress conditions and developmental processes in Chlamydomonas. Growth and stress processes mediate the formation of lipidic bodies and biomass in this specie, considered to be the third generation biofuel productor and CO2 trap. Research and training in –omics technologies are expected to stimulate European competitiveness in resolution of epigenetics and systems biology with significant scientific impacts and will help the implementation of Chlamydomonas in European climate change prevention strategies. Therefore “EpiSysBiol” is introducing EU prioritary research directions and topics, to improve the quality of European research in molecular and systems biology, to provide advanced expertise in epigenomics and to carry out interdisciplinary technical developments important not only for plant sciences but also for life sciences and for entire society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New techniques for handling quality and uncertainty in spatial mining' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The huge amount of spatial data may contain hidden information of significant importance for the experts of domain (e.g., astronomy, seismology, geology, medicine etc.) that could help them to further understand the data and make decisions. Ultimately we s eek to discover patterns in the data as opposed to knowledge about the data itself. Thus spatial mining techniques will be developed to discover the potential interesting characteristics and patterns that exist in large spatial databases. An important chal lenge in the context of spatial data management and decision-making is the handling of uncertainty. The spatial data and relationships in nature are not crisp. This implies that it is not a Boolean decision whether an object belongs in a specific area, or which its relationship is with other objects (sets of objects). Also there are relatively few efforts in the context of knowledge discovery that have devoted data analysis techniques in order to handle uncertainty. It is then obvious that there are inheren t features of spatial data that are not taken into account during the mining process and knowledge that is partially extracted. Then there is a need for defining a data model that represent the uncertainty in spatial data analysis process. Moreover, the re quirement for exploiting the inherent uncertainty of data in the quality assessment of mining results and decision-making arises. Also spatial data are commonly viewed as infinite sequence of data. Thus issues related to the effective mining of such data a nd the quality of the mining results due to their frequent updates are emerged. In the context of this project we will address the above issues of uncertainty representation and quality assessment in the context of spatial mining. A spatial mining framewor k
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structural basis and specificity of antigenic peptide trimming by the newly discoverd ER aminopeptidases ERAP1 and ERAP2', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The recognition by cytotoxic lymphocytes of antigenic peptides presented by MHC class I molecules plays a crucial role in cellular defences against viruses and cancer. MHC class I molecules present peptides that are 8-9 residues long and are derived from p eptides generated during degradation of proteins by the proteasome. However, proteasomes generally release longer precursors to the presented epitopes. These precursors are trimmed further in the Endoplasmic Reticulum (ER) by the recently discovered aminop eptidases, ERAP1 and probably also ERAP2. Over-expression or depletion of ERAP1 has strong effects on the presentation of peptide epitopes in vivo. This enzyme has the novel property of trimming N-extended precursors to peptides of 8 or 9 residues, the siz e required for loading onto MHC class I molecules, and then stopping. A highly homologous aminopeptidase LRAP (ERAP2) is also find in the ER although its antigenic peptide trimming properties are still obscure. Unlike typical aminopeptidases, ERAP1 display s specificity for amino acids located away from the N-terminus of the peptide, raising the interesting possibility that its specificity correlates with the binding preferences of MHC-Class II molecules. Because of their importance in immunology and very un usual biochemical properties, greater information about their biochemical features is of major scientific and medical interest. To gain insights to the mechanism and specificity of these enzymes, I propose to solve the three dimensional structure of ERAP1 and ERAP2 by x-ray crystallography and to further characterize their peptide trimming specificity by enzymatic and biophysical methods. Such studies should help us understand the molecular basis of their unique properties and obtain insights on their spe cifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'All Solid-sTate Reliable BATtery for 2025'.

assistant: **Innovation**

Europe is facing a major challenge to develop and produce a competitive Li-battery product in order to avoid dependency on third countries in its energy transition models. The Li-ion cell innovations should meet specific technical and economical requirements to sustain the market growth. The all-solid Li-ion technology appears to be one of the relevant options but it still has to be brought to higher TRL to be economically and environmentally friendly for a mass production compatible process. The ASTRABAT project gathers 14 partners, leaders in the different fields of research, development and production, from 8 countries. It aims to find optimal solid-state cell materials, components and architecture that are well suited to the demands of the electric vehicle market and compatible with mass production. The project will comply with improved safety demands and industrial standards.  Five ambitious objectives were defined:1.       Development of materials for a solid hybrid electrolyte and electrodes enabling high energy, high voltage and reliable all-solid-state Li-ion cells2.       Gen#2D cell design: processing techniques compatible with existing routes of large scale cell manufacturing (10Ah, Energy type) and validation of a pilot prototype in a relevant industrial environment3.       Development of a 2030s eco-designed generation for Power-type and Energy type all-solid-state cells in pre-prototype (Gen#3DS and #3DC)4.       Define an efficient cell architecture to comply with improved safety demands5.       Structuration of the whole value chain of the all-solid-state battery, including eco-design, end of life and recyclingThe project will reinforce the European battery value chain, strengthen collaborations between RTOs, SMEs and Industrial partners from material d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Impact of Decoupling and Modulation in the Enlarged Union : a sectoral and farm level assessment' (IDEMA), addressing dissemination and exploitation.

assistant: **Impact**

The research aims to develop methods and tools to provide a comprehensive socio-economic assessment of the impact of decoupling and modulation on the EU farm sector. The project will assess the impact of decoupling on demand and supply, trade, localisation of production, land use, environment, land markets, structural change, farm income, and farmers' entry/exit behaviour. Since no single methodological approach is able to take into account all aspects of this issue, the project is organised around three complementary approaches. These approaches are: (a) survey-based analysis of farmers' strategic decisions, (b) dynamic farm level/regional modelling and (c) sector level/general equilibrium modelling. A survey for analysing farmers' strategic behaviour will be developed and tested in selected current and new Member States, using a stratified sub-sample of each country's FADN population. Survey responses will be analysed in conjunction with FADN information. A spatially-dynamic, agent-based model, AgriPoliS, will be enhanced and adapted to selected regions typical for the different natural and socio-economic conditions of the enlarged Europe. Enhancing the farm-based model allows for analysis of structural change and impacts on farm incomes. An environmental impact module, linking land use and production technologies to indicators of environmental quality, will also be developed. A partial equilibrium model (ESIM) and country specific general equilibrium models, for the new members and the EU-15, will be further developed. These models will be extended to include a representation of land markets. Farmers' investment decisions and labour supply will be modelled, accounting for imperfections in capital and labour markets. Simulations will quantify impacts on production, co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Making new local policies against social exclusion in European citi es. Ecosocial approach and social impact assessment in social work' (1994-1998).

assistant: **Concept**

Since the integrative function of the labour market in European post-industrial societies is seriously weakening, the significance of citizens' living area as a key environment of social integration becomes crucial. However, the living areas of European cities once built for working people of industrial society, do structurally ignore the comprehensive social needs of unemployed citizens of today. Consequently the processes of exclusion in European cities are a ticking social and economic time bomb, if the changed demand for living environment with options of participation cannot be responded to. To effect these processes on the local level of policy making, new analytical approaches for identifying the interrelation between social exclusion/integration and the quality of living environment are extreme necessary. The main objective of the project is to influence the local policy making from the margialized people's point of view concerning social environment as a risk/ a resource for social integration in the context of different European urban areas. The detailed objectives are: - To provide effective methods of social work, that enable especially the unemployed citizens to improve their environment through participation (Social Action, Community Empowerment, Self-employment). - To apply the Social Impact Assessment (SIA) as citizens' and social work's tool to influence city planning and local decision-making towards a new social sustainability ((re)constructions, service and traffic politics, space utilisation). - To advance the European social work's theoretical knowledge on the ecosocial dimensions of exclusion processes in different urban contexts (combining the system theoretical and ecological approaches and the new urban poverty research). To meet these objectiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Predictive maintenance and diagnostics of railway power trains'.

assistant: **Innovation**

The railways industry is facing major technical and economical challenges due to the increasing transport demand for passengers and goods (market share of railways will double from 2000 to 2020) that could be only achieved thanks to increased reliability and availability of rolling stocks. ALSTOM-Transport (AT) is convinced that to answer its customers expectations and to improve its competitiveness, it is of prime importance to achieve breakthrough innovations in the field of diagnostic tools and maintenance methodologies for a key element of rolling stocks: the power train.However, to fulfill, the gap between traditional maintenance methodologies and predictive maintenance that has demonstrated its effectiveness in other industrial areas, ALSTOM-Transport needs to develop tools and methodologies based on knowledge on materials, fault diagnosis and data transfer system that the company does not own today. The objective of the PREMAID project is to set up a transfer of knowledge program between four academic centers located in Italy, Spain Poland and Portugal (UNIBO, UNIOVI, GUT and IT-Coimbra) that have developed complementary expertise sought by ALSTOM-Transport that in return will transfer, its knowledge on development, tests and manufacturing of motors and power electronics for railways applications.The project will involve 15 experienced researchers during 3 years. They will be mainly hosted (13) in ALSTOM-Transport research centre located in Tarbes for secondment periods from 2 to 24 months. Researchers from AT will carry out complementary researches, validate transfer of knowledge and launch new research programs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Programmable synthetic cell communication via coacervate-mediated dynamic clustering' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The current global human crisis in climate, health and energy calls for the development of new biotechnological innovations. The engineering of living cells has demonstrated its efficiency to produce drugs or degrade pollutants, but living cells also come with major limitations. Synthetic cells are human-made robust micro-compartments that reproduce key features of living cells from non-living matter, and are now being engineered to tackle key societal challenges of the European Union, including environmental clean-up, energy production or drug delivery. The integration of multiple functional modules in a single synthetic cell, required to perform complex tasks, remains yet a grand challenge. A promising alternative to increase the functionality of synthetic cells is to distribute multiple functions into specialized compartments able to communicate with each other through chemical signaling to perform tasks collectively. However, chemical communication between synthetic cells remains poorly controllable and programmable. The aim of this proposal is to develop a new platform to quantitatively study chemical signalling between synthetic cells based on their dynamic clustering. For this purpose, we will engineer switchable sticky coacervate droplets to selective interact with enzymatically active vesicles and promote their reversible clustering in response to light or pH. The bottom-up assembly of vesicles will be achieved by microfluidics due to modularity and reliability to produce structurally well-defined architectures. Optical tweezers will be used to study the coacervate-mediated interactions between vesicles and quantify their chemical signalling via confocal fluorescence microscopy and spectroscopy. The skills and experience of the candidate in stimuli-responsive b