RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Targeted Nano-Photomedicines for Multi-spectral Photodynamic Therapy of Cancer' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

We propose to develop multifunctional, targeted nano-photomedicines that are capable of bypassing biological barriers to deliver nano-engineered photosensitizer drugs and molecular-imaging agents to tumor tissues and angiogenetic micro-vasculature. Specifically, a unique nanomedicine system for targeted multi-spectral photodynamic therapy is proposed. The system consists of (i) luminescent quantumdot (QD) conjugated with photosensitizer (PS) drugs, which can be sensitized at its maximum efficiency using radiations of deep-tissue penetration (ii) molecular-imaging agents for the early stage detection and in situ treatment-effect analysis (iii) active targeting ligands to specifically target tumor and micro-vasculature. During the incoming phase, QDs of ZnS, Y2O3 and Gd2O3 emitting multi-spectral light under excitation with deep high-tissue penetrating radiations will be conjugated with PS so as to sensitize them at their characteristic absorption using Fluorescent Resonant Energy Transfer (FRET). The QD-PS will be combined with MRI contrast agents using `core/shell’ nanotechnology and made water soluble by capping with polyethylene glycol (PEG). Finally, the nanomedicine will be connected with tumor specific ligands such as folic acid, MAbs and peptides. Optimization of nanomedicine will be carried out by studying dark and photo-toxicity in normal and cancer cell-lines in vitro. Photodynamic treatment will be carried out in pre-clinical animal models using multispectral radiations under different photo- and drug-dose conditions, followed by molecular imaging (MRI) based estimation of PDT response-dose inter-relationships.  During the return phase, scanning probe imaging based investigations on the mechanism-of-activity of nano-photomedicines at intra-cellular regions lea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A concerted action appraisal of health system performance in central america.' (CAHSPA).

assistant: **Concept**

A Concerted Action will apply and disseminate techniques for measuring health system performance developed in a previous EC funded research project, to the comprehensive appraisal of health systems and health policies in Guatemala, Nicaragua, El Salvador and Costa Rica. The project will use existing data sources to produce indicators of the 5 key dimensions of performance: health gain; equity in service delivery and outcomes; social security against catastrophic health expenditure; client-oriented service quality; and total health system cost. A full description of the health policies and health system configurations of the four countries will be made and related to the performance measures in each area. This will produce a comprehensive appraisal of these health systems, identify policies or characteristics associated with high or low performance in specific areas, and serve as a model for future health system appraisals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Terahertz Spin Wave Logic'.

assistant: **Objectives**

Finding a fundamentally new approach for data processing in the fastest and most energy efficient way is a frontier problem for applied physics and technology. The amount of data generated every second is so enormous that the heat produced by modern data centres has already become a serious limitation to further increase their performance. This heating is a result of the Ohmic dissipation of energy unavoidable in conventional electronics. At present, the data industry lacks a solution for this problem, which in future may contribute greatly to the global warming and energy crisis.An emerging alternative approach is to employ spin waves (magnons) to realize waveform-based computation, which is free from electronic Joule heating. However, the present realization of this approach, called magnonics, uses electric currents to generate and modulate magnons. This project aims to replace the electrons with light using antiferromagnetic materials, in which spins precess on a picosecond timescale and strongly couple to electro-magnetic waves. This interdisciplinary approach at the interface between magnetism and photonics not only circumvents Ohmic losses, but simultaneously pushes the operation of magnonics to THz clock-rates.  Firstly, we will develop theoretical framework and a numerical solver to describe antiferromagnetic spin dynamics, strongly coupled to electro-magnetic radiation at THz frequencies. Secondly, we will develop prototypical antiferromagnetic logic elements that may have an enormous impact upon future magnon-based information processing technology. These two tasks will be pursued in parallel as the development of the solver will be validated through comparison of the numerical results with the experimental data, while the design of the magnonic logic will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Occupational stress with mental health clients in acute response (OSCAR)' (OSCAR).

assistant: **Concept**

Occupational stress features highly in both the hospital and community-based mental health workforce, particularly with respect to violent severely mentally ill clients. This project aims to address the problem of occupational stress by producing European comparative baseline data, and by developing and evaluating trans-European training packages, which include standardised and effective stress reduction and risk assessment procedures. Objectives are to evaluate on a European, trans-national basis levels of occupational stress and burnout, to examine the aetiological factors which precipitate the occurrence of violent behaviour, to examine the efficacy of risk management strategies, and to develop and evaluate effective stress reduction training packages. The method is a quasi-experimental research study. Outputs include a European database, standardised and evaluated risk assessment and stress reduction training packages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Massive Digital sequencing by binary DNA'.

assistant: **Objectives**

DNA sequencing costs have fallen more than 50-fold over the past decade, driven part by tools, technology and process improvements made during the Human Genome Project. However, it still costs around $10 million to sequence 3 billion base pairs - the amount of DNA found in the genomes of humans and other mammals.  1st generation sequencing platforms, which are based upon capillary electrophoresis and fluorescence detection, have been around since 1992. Due to poor price/performance parameters several initiatives have been launched to facilitate a replacement of this sequencing technology. Most notably is the US National Institute of Health with the goal of developing 2nd and 3rd generation technologies that can read a human genome for $100.000 and $1.000 respectively.   To date four vendors have introduced 2nd generation platforms to the market and they have the capacities of sequencing between 0,5 to 2 Gb per 24 hours.   The main limitation for improved price/performance of 2nd generation platforms is that they are based on an expensive CCD-camera set up. As a consequence new and radical approaches are required to meet the $1.000 genome goal.   This proposal aims to develop a high-throughput low cost 3rd generation DNA sequencing instrument, by deploying novel DNA preparation methods and read-out technologies. The potential instrument output is 200-300Gbp raw sequence per run, which allows for whole genome sequencing on a mass scale. A consortium of five European partners with multidisciplinary expertise has been established to reach the overall objective of this ambitious project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Starting the Sustainable 6G SNS Initiative for Europe' in the context of a Horizon Europe call.

assistant: **Objectives**

The 6GStart project will facilitate the preparation activities of the European Smart Networks and Services Joint Undertaking (SNS JU)  Initiative. This work will maintain the European momentum and leadership in 5G achieved through the 5G PPP and carry it forward to the new 6G SNS JU. It will bring the relevant players together to prepare the SNS JU by building on the work done to date in the 5G PPP.  This approach will contribute significantly to Europe having a leading role in the definition, provision, and exploitation of 6G by 2030.The 6GStart project will ensure the inter-project collaboration structures and mechanisms will be established and in place by the time the first phase projects of the SNS JU start. As such, the 6GStart project will ensure the fast launch of the new SNS  partnership and the availability of an efficient operational infrastructure for the inter-SNS-project coordination.  The infrastructure for the 50+ ongoing 5G PPP projects will also be supported.The 6GStart Project will also orchestrate collaborations, and capture and promote the achievements of the new 6G SNS initiative and the ongoing 5G PPP by facilitating their activities in inter-project working groups and maintaining links to the NetworldEurope community and the 5G-IA membership. The 6GStart project will support the running of two editions of the EuCNC&6G Summit events in 2023 and 2024, as well as assisting the organisation of the Global 5G/6G events based on the inter-regional MoUs managed by the 5G IA, contributing to the strategy of promoting the European achievements in the wider ICT sector.


**Keywords:** SNS, 5G-PPP,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeting SWI/SNF complex function in cancer' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cancer can be considered a disease of gene control; since dysregulated patterns of gene expression are a feature of all tumours. Excitingly, targeting the underlying epigenetic mechanisms that promote oncogenic gene expression in cancer cells is providing significant opportunities for cancer drug development. Indeed, initial successes in this area may soon be leveraged for the benefit of cancer patients. Expanding European research capabilities in this area is essential, since approximately 1.5 million people die from cancer each year in Europe; and projections indicate that this number will increase in the coming decades. The work described in this application is at the cutting-edge of cancer drug target discovery, and drug development. My work identified the SWI/SNF complex component BRD9 as a novel drug target in several malignancies; and drug development efforts have led to first-in-class BRD9 degrader compounds. Testing the in vivo efficacy of these novel compounds as anti-cancer agents (WP1) will be essential if we are to translate these compounds to clinical investigations. Moreover, the work described in WP2/3 will be essential to fully exploit the potential of BRD9 as a drug target and identify additional opportunities for future drug development. My expertise in the areas of epigenetics and drug development make me the ideal candidate to pursue the outlined research program. Moreover, the support of this Action will give me the opportunity to develop further as an independent researcher; both in terms of technical expertise and transferable skills. These additional skills will allow me to achieve my long-term career goal of establishing my own independent research program, focusing on cancer epigenetics/drug development within a European context. Dissemination
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Imaging function and dysfunction of neuronal circuits in the visual cortex' (EUROV1SION) targeting Seventh Framework.

assistant: **Abstract**

The research program aims to understand the dynamics of the structural and functional organization of the visual cortex and the implications for amblyopia ('lazy eye', the most prevalent visual disorder among young people). We will study these fundamental issues from the molecular level all the way to the network level. To achieve this, members of the consortium have - for the first time - established chronic in vivo two photon imaging of Ca2+ responses in the visual cortex by making use of a novel genetically encoded Ca2+ sensor. Using this powerful new methodology we will study how experience changes firing properties of individual neurons of known identity and how this correlates with changes in inhibitory and excitatory synaptic structures. Using the same approach we will study the neuronal substrate of amblyopia and how it alters coding of visual information. Next we will study how binocular experience leads to recovery from amblyopia and how perceptual learning can improve this in animal models and human subjects. This knowledge will be directly translated into new treatments of amblyopia by one of the participating SMEs. Last we will study the molecular and cellular mechanisms that restrict plasticity in the adult visual system with the aim to achieve increased experience dependent plasticity in the adult brain. This knowledge can be used for the treatment of disorders of the CNS from which recovery is limited due to restricted plasticity. Apart from amblyopia, these include brain tumors, stroke, degenerative diseases and trauma. Together this program will provide comprehensive insight into the neuronal interactions underpinning function and dysfunction of the visual cortex and will contribute directly to improved treatment of amblyopia and development of plastic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Evaluation of in-vitro test methods to characterize bone implant materials with special emphasis on biocompatibility and long-term functionality' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Assessment of the long-term performance of bone implants in contact with body fluids and tissue materials with special regard to i.) events happening at the phase boundaries on a mo]ecular level, and, ii.) the cellular changes observable in these systems as a function of time leading to the establishment of test methods for biocompatibility and functionality of bone implant applications and of cell culture techniques as powerful tools for these types of investigations, the prediction of the long-term performance of implants in body environments, the verification of concepts of biomedical engineering and both the proposal for a Europan technical recommendation as well as a European data base of bone implant material interactionsImplant materials such as bone implants in orthopaedic and dental practice undergo degradation processes after implantation. This includes the release of certain amounts of dissolved or particulate implant components into the adjacent tissues. Particles, metal corrosion complexes and metal ions are suspected of producing an inflammatory response in the surrounding tissues. On reaching the blood stream or the respiratory system, even a systemic influence of those degradation products may be envisaged. Recent]y published studies have shown that degradation products even in low concentrations, released from commonly utilized materials might, on the basis of their broad spectrum of effects be an important factor in inflammation and inhibition of wound healing processes. Current discussions on implants present evidence that there is a need for a standardized, comparable and reliable testing scheme for materials provided for implantation with respect to their degradation reactions.Aim of the present project is the establishment of in vitro testing metho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PERSONALIZED NON-INVASIVE NEUROMODULATION IN PAIN' in the context of a Horizon Europe call.

assistant: **Objectives**

Chronic pain (CP) is the most prevalent disease worldwide and is a major societal challenge. Different people with the same pain condition experience it differently. Irrespective of its origin, CP is maintained by altered connectivity between brain regions, which can be modulated towards normality by effective treatment.  Several pharmacological and non-pharmacological strategies exist to treat pain, but 40% of individuals remain symptomatic despite treatment. Current treatment for CP is not personalised, being delivered in a standardised regimen irrespective of patients' brain network status, which partially justifies therapeutic refractoriness. Non-invasive neuromodulation (NIN) techniques such as repetitive transcranial magnetic stimulation (rTMS) are used in the long-term treatment of a wide spectrum of brain disorders as an alternative to medication-exclusive regimens. NIN can modulate altered connectivity towards normal patterns and relieve symptoms with minimal side effects, but to date its application has also been non-individualized, which equally impacts its therapeutic potential. I propose a comprehensive package of studies using measurements of local-to-global brain connectivity to individualize pain treatment. By probing different brain regions by single pulse-TMS and reading the subsequent brain oscillatory responses by electroencephalography, one can screen potential treatment targets and classify them according to their efficacy potential in a pre-treatment session. This will allow the identification of the best cortical region to be used as treatment target by rTMS, thus providing a personalized choice of the ideal entry-spot to drive brain global connectivity towards normalized patterns for each patient.With the development local-to-general brain conne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Non-abelian anyons in programmable lattices' (NON-ABELIAN), addressing dissemination and exploitation.

assistant: **Impact**

Non-abelian anyons are conjectured topological quasi-particles which shatter our understanding of quantum statistics. Exchanging two such quasi-particles can transform the quantum state in a way that cannot be undone without unwinding the exchange. The exotic properties of non-abelian anyons have puzzled researchers for decades, and the robustness associated with their statistics makes them an appealing platform for topological quantum computing. Despite broad research over the past decades, non-abelian anyons defy a conclusive experimental observation.The goal of NON-ABELIAN is the realization and exploration of non-abelian anyonic quasi-particles. We will focus on two paradigmatic systems: quasi-hole excitations in Pfaffian-type fractional quantum Hall states, and Majorana edge states in the Kitaev chain. In each system, we will use control on the microscopic level to prepare the many-body ground state, as well as to isolate, braid, and fuse its quasi-particles. Using local correlations and interferometric observables, we will reveal the properties, including their fractional charge and their non-abelian statistics. The experiments are carried out on a novel type of neutral-atom platform. It makes use of ultraprecise holographic beam shaping, programmable optical tweezer arrays, and rapid ground state cooling techniques.By studying the emergence of non-abelian quasi-particles in two complementary systems, this project will shed light on an elusive type of quasi-particle from new angles. This will lead to fundamental consequences on our understanding of quantum statistics and provide microscopic insights into strongly correlated topological systems. In addition, our experiments open avenues for topological quantum computing with cold atoms.


**Keywords:** ultracold fe