RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Palaeoenvironment and palaeoclimatic evolution of the Baltic sea basin during the last interglacial (Eemian, Mikulino)' to be submitted under Fourth Framework.

assistant: **Abstract**

The Last Interglacial (Eemian, Mikulino, Oxygen Isotope Stage [OIS] 5e: c.130-115 ka) is of particular interest to palaeoclimatology because it was characteristically warmer, had higher CÀ2 concentrations, higher sea levels and possibly more unstable conditions than during the present interglacial (Holocene, 0-10 ka). Moreover, the effect of these higher sea levels on the climate and environment of northern Europe remain very poorly understood. Preliminary geological evidence suggests that the Baltic Sea was significantly more extensive with a connection to the White Sea, effectively turning Fennoscandia into an island during some part of the last interglacial. The occurrence of a potentially enlarged water body may have been profound on the climate of adjacent landmasses as well as on palaeoeceanographic circulation patterns and deserves particular attention in the light of future climatic scenarios with higher sea levels. The BALTEEM project aims to investigate obtain and synthesise high-resolution palaeoclimate and palaeo-oceanographic records from the Baltic Sea region covering the period of the Last Interglacial in order to enhance our understanding of the role of this shallow marine basin as a component of the Global Climate system in the European sector. This objective will be achieved by the implementation of an integrated work programme involving contributors from six European countries.The investigation will consist of a transect from Northern Denmark to Arkhangelsk, via Karelia, Poland and Estonia and will be focused exclusively on sediment sequences that span the whole, or almost all of the Last Interglacialin marine sediments known to occur in these areas. Each site will be investigated using a standardised palaeontological and sedimentological approach, su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sociality and division of labour: microbial, behavioural and epigenetic interactions' in the context of a Seventh Framework call.

assistant: **Objectives**

Understanding the evolution and maintenance of cooperation is one of the major challenges in biology and is epitomised by the eusocial insects, which Darwin even considered to be potentially fatal to his theory of natural selection. Hamilton’s seminal papers revolutionised our understanding of evolution by explaining cooperation in social insect societies via kin selection, where individuals gain fitness by helping their relatives. But, in the absence of an overarching manager, how is it decided who does what tasks in these cooperative societies? Most biological research considers individual animals as discrete entities, however they in fact host a plethora of symbiotic microbes that can have significant beneficial or parasitic effects on their hosts. The importance of these symbioses is now beginning to be understood - gut microbiota have been found to affect, and be affected by behaviour and the expression of associated genes in different animals. Gut bacteria and behaviour in social insects are known to be influenced by many of the same factors (e.g. age), however, the relationship between microbial associations, sociality and division of labour, remains almost entirely unexplored. To address this gap, this project will investigate the relationship between microbial communities and the evolution of sociality, individual behaviour and division of labour, and the role in these of DNA-methylation-mediated effects. This will be achieved by sequencing and characterising the gut bacteria community and epigenetic architecture of workers performing different behaviours, experimentally manipulating the microbe communities, and also characterising individuals with different social phenotypes from a single population. This project will provide important insights into the bidire
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'AMPA Receptor Dynamic Organization and Synaptic transmission in health and disease' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

AMPA glutamate receptors (AMPAR) play key roles in information processing by the brain as they mediate nearly all fast excitatory synaptic transmission. Their spatio-temporal organization in the post synapse with respect to presynaptic glutamate release sites is a key determinant in synaptic transmission. The activity-dependent regulation of AMPAR organization is at the heart of synaptic plasticity processes underlying learning and memory. Dysfunction of synaptic transmission - hence AMPAR organization - is likely at the origin of a number of brain diseases.Building on discoveries made during my past ERC grant, our new ground-breaking objective is to uncover the mechanisms that link synaptic transmission with the dynamic organization of AMPAR and associated proteins. For this aim, we have assembled a team of neurobiologists, computer scientists and chemists with a track record of collaboration. We will combine physiology, cellular and molecular neurobiology with development of novel quantitative imaging and biomolecular tools to probe the molecular dynamics that regulate synaptic transmission.Live high content 3D SuperResolution Light Imaging (SRLI) combined with electron microscopy will allow unprecedented visualization of AMPAR organization in synapses at the scale of individual subunits up to the level of intact tissue. Simultaneous SRLI and electrophysiology will elucidate the intricate relations between dynamic AMPAR organization, trafficking and synaptic transmission. Novel peptide- and small protein-based probes used as protein-protein interaction reporters and modulators will be developed to image and directly interfere with synapse organization.We will identify new processes that are fundamental to activity dependent modifications of synaptic transmission. We w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'bEhaVioral Insgihts anD Effective eNergy policy acTions' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Energy efficiency lies at the very core of policy interventions for energy security, energy poverty and climate change, while its promoted by technological innovations and investments. However, it seems that these technologies are not adopted by consumers at least to the extent that the assumption of rational behavior would predict. This energy efficiency gap, the difference between expected and realized energy consumption, costs to national economies both in terms of monetary values and emissions. Significant role in mitigating this issue is the exploration of the drivers of individual behavior. There is tremendous opportunity and need for policy-relevant research that utilizes randomized controlled trials and quasi-experimental techniques to estimate the returns to energy efficiency investments and the adoption level of energy efficiency programs. EVIDENT proposes several different case studies under the framework of randomized control trials (RCTs) and surveys in order to define the main drivers of individuals’ decision making and to establish new relationships between energy consumption and other fields such as financial literacy. A large number of participants, well stratified samples, innovative design of experiments and state of-the-art econometric models that will be employed in EVIDENT and will contribute in robust estimates and subsequent policy measures for effective policy interventions.


**Keywords:** Behavioural insights,  random control trials, energy efficiency, policy implications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional relationships between visual cortical imaging and evoked synaptic integration' (CHAVANEFREDERIC).

assistant: **Innovation**

We intend to combine in vivo optical imaging and intracellular recordings in order to evaluate the involvement of primary visual cortico-cortical connections into elementary perceptual processes. We will focus on spatial lateral interaction and context dependent integration of visual information.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Promoting excellence in Life Sciences - Fostering transnational mobility and scientific exchange through co-funding of the EMBO Long-Term Fellowship Programme', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The EMBO Fellowship Programme supports international mobility and exchange in all areas of the life sciences. Renowned for its commitment to scientific excellence, the programme has funded thousands of talented early career scientists since its establishment in the 1960s. EMBO Long-Term Fellowships support advanced research and training by awarding funds to postdoctoral scientists for research visits between European countries or when justified worldwide. Since 2002, the number of applications for EMBO Fellowships has more than doubled, creating a situation in which the number of excellent proposals exceed the available funds. In 2007 and 2010, EMBO successfully applied for co-funding, which made it possible to award a significantly higher number of fellowships. In order to be able to meet the continued high demand for postdoctoral training in the life sciences EMBO applied to the 2012 COFUND call. Continued co-funding of the EMBO Long-Term Fellowship Programme will not only allow selected fellows to enjoy the benefits and high prestige of an EMBO Fellowship – co-funded by a Marie Curie Action – but will also promote the further development of the European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SOmatic MUtagenesis in Kidney Tubule is enhanced by specific metabolic pathways' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

An important factor favoring cancer initiation is the lifelong accumulation of somatic mutations in the genome. In agreement, somatic mutations in a specific set of driver genes has been shown to drive the transition from a healthy cell to a tumorigenic clone in the kidney. The vast majority of kidney tumors originate from a specific segment of the kidney nephron, named proximal tubule (PT). However, the rate of somatic mutation accumulation before tumorigenic transformation in the kidney PT and the causes underlying this phenomenon are unexplored. Somatic mutation data can be used as a footprint to track the mutational processes that occurred in a specific cell during an individual´s lifetime. I established a protocol for reliable detection of somatic mutations in non-cancer human cells. I obtained whole genome data from clonally expanded single cells from skeletal muscle, kidney, fat and skin of healthy donors. My preliminary data point to an increased rate of somatic mutation accumulation during adult life in kidney PT compared to other kidney and non-kidney cells. PT cells showed a unique mutation pattern and distribution that enhances the chances of acquiring a driver mutation and tumorigenic traits. The very homogeneous pattern of somatic mutations in PT cells leads me to the hypothesis that the kidney PT is exposed to genotoxic compounds that are endogenously produced during physiological cellular activities. In particular, my data point to specific metabolic pathways, including 1) ammonia production, 2) aminoacid metabolism /reabsorption from the urine and 3) response to hypoxia. I will use cellular models to perturb the metabolic homeostasis of the kidney PT and test the effect on somatic mutagenesis and underlining mechanisms. My project will shed light on a m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Financial Integration in Europe and the Propagation of Shocks' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Abstract This project aims at developing a solid understanding of the channels through which shocks are transmitted through and between financial markets in Europe. In particular, we will study the role of the banking market, the bond market, and the equity market for the transmission of shocks. In order to thoroughly assess the role played by Europe's financial markets for the propagation of shocks we will also study the links between financial market development and real economic activity. We will analyse the exposure of banks to changes in risk in integrated markets and the transmission of shocks through cross-border activities of banks. In order to improve our understanding of how the European bond markets work after the launching of the euro, we will evaluate potential differences in the transmission of the single monetary policy on the macroeconomic variables of the different EMU members.The project will clarify how equity market integration has affected the transmission of shocks across countries and how vulnerable European equity markets are to contagion effects. As evidenced by the recent turmoil in Asia, this is of utmost societal importance. We will also investigate the links between financial market developments and real economic activity in the EU. Our results will help to assess how autonomous financial market shocks propagate through financial markets and how an initial purely financial shock may eventually affect real economic activity. As the project covers the most important segments of European financial markets, our research will have a significant impact on a broad spectrum of policy issues including banking supervision, the promotion of bond market liquidity, the reforms of equity market institutions, and not least macroeconomic policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MUltimetallic SYstems for C-H Activation processes' under Horizon 2020.

assistant: **Concept**

MUSYCA - Multimetallic Systems for C-H Activation processes - is a project designed to obtain a better understanding of the key factors governing C-H activation phenomena in multinuclear copper-based cores present in the most efficient frameworks such as enzymes or zeolites like methane monooxygenases (MMOs) or Cu-ZSM-5, respectively. One of the main goals of the project is to obtain complexes containing Cu2O entities, which have not yet been interrogated and are reactive enough to oxidize C-H bonds. These will be employed in the stoichiometric and catalytic transformation of hydrocarbon bonds of numerous substrates, from easily convertible to extremely challenging ones, being methane the stretch goal. The reactivity patterns and the corresponding mechanisms underlying the formation of Cu-O fragments as well as those involving the formation of C-O bonds will be studied by using a wide variety of analytical techniques. To this end, robust 2,7-substituted [1,8]naphthyridine scaffolds will be employed as dinucleating ligands, since they resemble the environment surrounding dinuclear active sites in natural enzymes and they facilitate a close interaction between the metals, at the same time that the chelating groups in positions 2 and 7 help to stabilize the resulting complexes. These ligands will also be employed in the other major target of the project, which consists of the development of dinuclear Pt-Cu compounds so as to evaluate the metal cooperativity in a modified Shilov system for C-H activation. Only a few studies have been carried out on the role of copper in the Shilov-type C-H functionalization reaction, showing its great potential for improving the catalytic performance of the active species involved in the process. However, the role of Pt as active catalyst a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Initial Training Network for Wave Energy Research Professionals'.

assistant: **Innovation**

The proposed action builds strongly up on the logics of its predecessor with the same name. The overall objective is to create a pool of specialised wave energy research professionals to support an emerging industry in a field with a very strong anticipated growth and no dedicated existing training curriculum. Although most jobs can be done being a trained engineer in one of the adjacent fields, the existance of interdisciplinary skilled researchers trained in direct connection to the technology development is vital for successful development. In the predecessor, almost all fellows where immediatley absorbed by industrial players in the field or continued research in the host institution. The work plan for WAVETRAIN 2 fellows is specifically directed towards a wide range of challenges that industrial-scale wave energy implementation faces in the present situation, with some bias towards technical issues, from hydrodynamic and PTO (Power-Take-Off) design, to instrumentation issues and energy storage and cost reduction show to be critical for successful deployment. On the other hand, also non-technical “barriers”, typically less tangible difficulties related to legal issues (licensing, conflicts of use, EIA procedures, grid connection, regional differences) and the non-sufficient representation of socio-economic benefits of the sector, will be dealt with, as they are seen as a major obstacel for fast implementation on a European scale. The methodology to achieve the desired results is to provide (i) in-depth training in one applied research topic (host institution), (ii) good interdisciplinary background and understanding of industry environment (short courses and secondments), and (iii) active participation in wave power plant testing in the sea (some of the profiles; ot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Computational Biophysics: Integrating Theoretical Physics and Biology' under Fifth Framework.

assistant: **Concept**

This meeting is focused on the application of theoretical physics - from first-principles to classical simulations, as well as statistical approaches - to understanding biological processes. The complexity of living systems, and the wide spectrum of time and length scales involved, demand a truly interdisciplinary cooperation. Recent progress in biology and in physics has opened up many opportunities in both fields. The human genome is now technically complete. We can, in principle, determine all human protein sequences. We cannot yet, however, predict the native morphology of a protein from its amino acid sequence, let alone identify the active sites and calculate binding energies. This is essential for screening new drugs synthesized in the hundreds of thousands by combinatorial chemistry methods, and is the most pressing issue in biology today.Many other biological processes of current interest can benefit from the application of physics, such as the binding of oxygen by transition metals for the design of artificial blood. Recent advances in theoretical physics have begun to impact biology, and the continuing development of new computers and algorithms is expanding the range of structures and time scales which can be treated to an extent that becomes relevant to biochemistry.Reflecting these themes, the objectives of the meeting include:- Bringing together international experts, both theoreticians and experimentalists, from the physics and biology communities;- Encouraging participation by industrial researchers;- Giving young researchers access to these experts;- Defining the state of the art of physical methods applied to biology, and to identify weaknesses and opportunities;- Identifying the combination of methods, skills and cross-disciplinary expertise that are