RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Eclipsing binary stars as cutting edge laboratories for astrophysics of stellarstructure, stellar evolution and planet formation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Spectroscopic binary stars (SB2s) and in particular spectroscopic eclipsing binaries are one of the most useful objects in astrophysics. Their photometric and spectroscopic observations allow one to determine basic parameters of stars and carry out a wide range of tests of stellar structure, evolution and dynamics. Perhaps somewhat surprisingly, they can also contribute to our understanding of the formation and evolution of (extrasolar) planets.  We will study eclipsing binary stars by combining the classic - stellar astronomy - and the modern - extrasolar planets - subjects into a cutting edge project.We propose to search for and subsequently characterize circumbinary planets around ~350 eclipsing SB2s using our own novel cutting edge radial velocity technique for binary stars and a modern version of the photometry based eclipse timing of eclipsing binary stars employing 0.5-m robotic telescopes. We will also derive basic parameters of up to ~700 stars (~350 binaries) with an unprecedented precision. In particular for about 50% of our sample we expect to deliver masses of the components with an accuracy   ~10-100 times better than the current state of the art.Our project will provide unique constraints for the theories of planet formation and evolution and an unprecedented in quality set of the basic parameters of stars to test the theories of the stellar structure and evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Crowdfunding for a low carbon energy system: addressing major challenges for EU-wide public and private investments in energy and carbon saving measures', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

A low carbon energy system is realizable with current proven technologies provided that appropriate investments for installing these technologies are made. The challenge with energy-efficiency measures is that they require high initial investments and are only profitable in the long run. Thus, many SMEs, non-profit organizations and local authorities cannot afford that or simply lack the interest of investing in these types of actions.bettervest bridges the gap between funding and action. It is the first crowdfunding platform that focuses on energy-efficiency projects from a size of 5.000 to 200.000 Euros and allows the crowd to benefit from the savings generated through the reduced energy consumption. A defined percentage of the savings is distributed to the crowd until the investment plus a previously agreed upon profit has been completely paid back. Additionally, the project owners can use the crowdfunding project as a customer bonding and staff participation measure that rise awareness for their corporate social responsibility activities and increases identification with the firm. The Federal Ministry for Economic Affairs and Energy (BMWi) estimates that the benefit of energy-efficiency measures in Germany belongs to 27 Billion Euros in 2012 by avoiding imports of fossil energy carriers. McKinsey estimates that again 850.000 jobs could be generated in the energy-efficiency sector in Germany by 2020. Until 2012 around 500.000 jobs have been generated (BMWi 2014). Applied to the EU these numbers should be multiplied accordingly. bettervest receives in sum a theoretical impact over an average contract period of five years of 3.750 MWh energy-savings and 4.500 tons carbon reductions for every 1.000.000 Euros funded within the crowd. The already funded projects would not
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of NDA procedures for the QA /QC characterisation of large volume radioactive waste packages' under Fifth Framework.

assistant: **Concept**

In most member states of the EU nuclear facilities (e.g. NPP) have at regular times large maintenance periods in which the possibility exists, that large components have to be released and treated as radioactive waste. At this moment large volume waste package (LVWP) form a minor quantity (less than 10%) of the total volume of radioactive waste, while it can be expected that in the near future, due to the age of most nuclear facilities, it will become an important fraction of the total waste offered. Therefore new NDA techniques, procedures and methods have to be developed to be able to perform independent QA/QC NDA characterisation. The development will be based on QA/QC NDA characterisation. The main effort will be the development of procedures and mobile NDA equipment for fissile as well for non-fissile waste, which can be used at the site of the waste producer (LVWP's cannot be transported in general to QA/QC facilities).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Antibody-functionalised cardiovascular stents for improved biocompatibility and reduced restenosis'.

assistant: **Concept**

An industry-academia collaboration is proposed wherein two industry and three academic partners will establish a lasting, inter-national partnership for transfer of knowledge in biomaterials engineering. The partners have synergistic competences in the medical device sector, and, aided by a schedule of staff secondments and networking events, their relevant niche expertise will be shared and transferred intersectorally. In all 16 researchers will be supported.Coronary artery disease accounts for two million deaths per year in Europe. The long-term outcome for patients is poor: 15% die or experience re-infarction within 30 days of initial diagnosis, while over 30% are re-hospitalised within 1 year. The estimated cost to the EU economy is €192 billion/year. The over-riding S&T objective of this collaboration is to develop a biomimetic cardiovascular stent prototype, by surface functionalisation with human antibody fragments, for improved coating by epithelial precursor cells in vivo. Sophisticated protein engineering and (nano)materials analysis from academic partners will interface with focused manufacturing and market experience of industry partners to deliver a stent with improved biocompatibility, reduced re-narrowing of arteries and superior clinical performance. Partners in interventional cardiology and industrial stent manufacturing will ensure clinical relevance and market-driven focus throughout design, development and post-project market entry.The collaboration will develop skill sets of individual researchers, strengthen research capacity at partner institutions and support important extant biomedical device clusters in Ireland and Poland. The clinical end product will significantly improve patient outcomes and quality of life for Europe’s citizens; reduce cost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Omi software architecture forum' (OSAF).

assistant: **Innovation**

The OMI Software Architecture Forum is a project to foster the growth and development of an open market for software components for embedded applications. This will include everything from dish-washers to set-top boxes and automotive components.Up to now, embedded systems have contained relatively little software and there have been few concerns as to reuse, interoperability, compatibility etc. However, with pervasive computing now on the crest of a wave these issues are coming to the fore. This was foreseen by OMI in establishing the software projects and recognising the need for a coherent strategy. However, progress to date has been relatively slow. It is therefore proposed to jump forward by means of this project through the creation of a well-organised forum for collective endeavour. The forum will be oriented not simply to standardisation but to creating the conditions in which standardisation will occur naturally. As the forum develops it will be able to take advantage of its unique relationship with the OMI community and its active RTD workprogramme. The work of the forum will naturally lend direction to the OMI workprogramme in software as well as giving rise to autonomous standardisation and rationalisation activities. The role of the project partners is to provide professional support to the forum and its working organs at a level commensurate with its objectives. The project will attract significant players from around Europe. This will increase the chances of adoption of the forum's deliverables and help to disseminate the results. The OSAF project will create deliverables of direct interest to OMI participants and companies in similar markets. Project Context :This project carries forward the OMI's building block approach to systems into the embedded softw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Silicon Capacitive Sensors for Biomedical Applications'.

assistant: **Concept**

The CASE project aims at transferring recent research results on capacitive sensors developed within European research projects from research institutes, namely CNM and IMEL, to an industrial Central European partner (Romes S.A.).This company is very experienced with microelectronics processes and devices and is fully equipped to process silicon wafers. Characterisation and reliability issues of the transferred technologies will be studied by the ICCE which is in close contact with Romes S.A. The Warsaw University of Technology will mainly focus on device characterisation. Recent research has shown that capacitive-type devices perform better than piezoresistive ones on issues such as low power consumption and high pressure sensitivity. The above qualifications make these devices very attractive for medical applications. A demonstration project is a good opportunity to start up this activity in Eastern Europe with an important social impact and with relatively low cost, since the fabrication infrastructure is already there.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bridging temporal resolution gaps to dissect RNA silencing at the molecular and genomic scale' (RiboTrace) targeting Horizon 2020.

assistant: **Abstract**

The implementation of distinct gene expression profiles is essential for organismal development, physiological responses to external stimuli or pathogens, and defines a primary cause for human disease. While much attention has been paid to the regulation of transcription, the control over RNA fate and function has only recently emerged as a central hallmark of gene regulation with enormous biological, technological and biomedical implications.Here, we propose to study the molecular principles of RNA silencing, the least understood aspect of post-transcriptional gene regulation. We aim to systematically dissect the mechanisms and biological functions of RNA 3end uridylation to determine the emerging role of RNA modifications in the regulation of gene expression; we will elucidate fundamental principles of RNA turnover at the genomic scale by time-resolved transcriptomics; and we will use functional genomics and haploid genetics to systematically delineate post-transcriptional gene regulatory pathways. Throughout, we will link our results back to the established function of RNA silencing in the control of organismal development, physiology and disease. Our goal is to acquire fundamental insights into the processes that survey the quality and quantity of the transcriptome to determine possible molecular causes for aberrant RNA levels that have been associated with diverse human diseases.Because of its genetic and biochemical tools, we will use Drosophila melanogaster as a model organism. We will employ a combination of in vivo genetics, cell-free biochemical experiments, bioinformatics, and cell culture methods. What we learn in flies we will test for its conservation in mammalian cell extracts and cultured cells.Overall, we will determine fundamental biological mechanisms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NEw WindowS on the universe and technological advancements from trilateral EU-US-Japan collaboration' (NEWS), addressing dissemination and exploitation.

assistant: **Impact**

NEWS promotes the collaboration between European, US and Japanese research institutions in some key areas of fundamental physics. LIGO and Virgo collaborations have built the largest gravitational wave observatories and exploit the propagation of light and spacetime to detect gravitational waves and probe their sources. The first observation of a signal from a merging black hole system has inaugurated the era of gravitational wave astronomy. The Large Area Telescope collaboration operates a gamma-ray telescope onboard the Fermi Gamma Ray Space Telescope mission and has revolutionized our view of the gamma-ray Universe, by increasing the number of known sources, unveiling new classes of gamma-ray emitters, and probing particle acceleration and electromagnetic emission in space with unprecedented detail. Fermi is the reference all-sky gamma-ray monitor for the follow-up searches for electromagnetic counterparts of gravitational wave sources. The multimessenger astronomical observations will soon be enriched by X-ray polarization detectors. New-generation space telescopes will measure the  polarization of X-rays from the cosmic sources and probe the laws of physics under extreme conditions of gravitational and electromagnetic fields. A complementary approach to probe the Universe is provided by particle accelerators built in laboratories. FNAL will provide the cleanest probes for physics beyond the Standard Model of particle physics. The Muon (g-2) experiment will measure the muon anomalous magnetic moment with unprecedented precision. Mu2e will search for the neutrinoless coherent muon conversion to an electron in the Coulomb field of a nucleus, which would be the unambiguous evidence of new, unknown, physics. These endeavors require innovative detectors and cutting-edge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Validation of a novel class of cyclophilin inhibitors for the treatment of non-alcoholic steatohepatitis'.

assistant: **Innovation**

Non-alcoholic steatohepatitis (NASH) is an increasingly prevalent chronic liver disease (3-4% of the US population) for which there is currently no approved drug therapy. In the absence of innovative treatments healthcare costs associated with this disease are set to triple over the next decade. To address this unmet medical need, the pharmaceutical industry is currently pursuing a range of liver fibrosis drug discovery programs based on different mode of actions. A compelling mechanism for treating liver damage is pharmacological modulation of the mitochondrial permeability transition pore in liver cells via inhibition of the protein cyclophilin D. However existing cyclophilin inhibitors based on peptidic macrocyclic scaffolds are challenging to optimize into sub-type selective orally bioavailable agents suitable for clinical trials of liver fibrosis. As part of basic research activities undertaken during ERC StG EBDD to validate a computational-biophysical drug discovery platform, we have discovered a structurally novel family of small molecules that inhibit cyclophilins by targeting a previously unexplored binding pocket. The objective of this POC is to identify a lead compound in this family with potential for development towards a NASH clinical candidate. Such a candidate will form the basis of follow-on lead optimisation programs pursued via partnering or out-licensing with a pharmaceutical partner. The activities of this POC will focus on assembling a data package of in vitro DMPK, in vivo PK, in vitro sub-type selectivity and in vitro and in vivo efficacy measurements in relevant cellular and animal models of liver fibrosis. This POC has been designed in consultation with a major pharmaceutical company and assembles a team of physical and biological scientists a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Analysis of Molten Salt-Air Heat Exchangers for Large Scale Energy Storage Technologies'.

assistant: **Concept**

Molten salt-air heat exchanger thermal sizing design influences the performance and, in turn, the cost-effectiveness of a range of emerging technologies (such as concentrated solar power integrated pumped thermal energy storage, process heating, and high-temperature processes like H2 production) supporting the green transition. As per 2019 reports, worldwide power generation capacity from molten salt storage in CSP plants was 60 GWh (thermal) and is expected to rise several folds by 2030 [1]. The primary goal of MAX4LES is to develop and provide a scientific benchmark for the optimal design of molten salt-air shell and tube heat exchangers. I aim to identify the cause and effect of freezing and time required for melting the solidified molten salt inside the tubes of molten salt-air heat exchangers. And to propose selective coatings to avoid the salt deposition on the tubes to prevent clogging that might lead to reduced performance and/or cause structural damage. The project outcomes will bridge the existing knowledge gap and support the future development of molten salt-air heat exchangers. The training at the host, Technical University of Denmark, Denmark, secondment at Eindhoven University of Technology, Netherlands, and the short stay and cooperation with the industrial partner, Aalborg CSP, Denmark, will provide me with the ideal technical, ethical, and cultural exchange and significantly strengthen my future career prospects. The intersectoral approach will provide the basis for implementing the research outcomes commercially. Overall, the project will set a foundation for me to continue focusing my expertise and skills to contribute toward meeting the long-term European Unions (EUs) Net-Zero decarbonization goals by 2030.


**Keywords:** Heat exchangers,  Freezing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional networks underlying emotion processing' (PFC-AMY) under Horizon 2020.

assistant: **Objectives**

Impairments in self-regulation of emotions are a substantial aspect of neuropsychiatric disorders such as anxiety disorder, major depression, bipolar disorder, and borderline personality disorder. These disorders account for up to 40% of years lived with disability, with depression as the main cause. Key characteristics of these disorders are changes in emotion processing, i.e. emotion perception, emotion reactivity and emotion regulation. From a brain network perspective, these emotion processing alterations were found to be associated with reduced activity in the prefrontal cortex (dorsolateral and ventrolateral prefrontal cortex), while at the same time limbic areas (particularly the amygdala) are overactivated. Transcranial magnetic stimulation (TMS), a non-invasive technique for modulating brain networks, is a promising tool to cure patients suffering from affective disorders. Current approaches, however, use TMS targets based on generic anatomy coordinates from group-average studies. It is this lack of patient-specific targeting which most probably causes the modest response rates observed in TMS therapy. This project will use cutting-edge neuroscience methods to provide innovative ways for the treatment of patients with emotional dysregulation. We will systematically investigate different network properties underlying emotion perception, reactivity and regulation in healthy participants to develop a connectivity-informed process model of emotion processing that could be used for clinical research. We will use individualised brain targets based on activation and connectivity patterns obtained in the same subject to improve TMS application accuracy and achieve optimal therapeutic benefit in each and every patient. We will compare the performance of this precision-m