RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Are non-nutritive sweeteners vascular-safe substitutes for added sugars?' under Horizon 2020.

assistant: **Concept**

In an effort to reduce the incidence of obesity, type 2 diabetes and cardiovascular disease, leading health agencies around the world are currently promoting the consumption of food and beverages containing non-nutritive sweeteners (NNS), advocating them as healthy alternatives to products sweetened with added sugars. As the harmful health effects of excess sugar consumption are often attributed to the high-energy content of added sugar, it has been assumed that NNS are physiologically inactive simply because they have little to no energy content. Recent evidence, however, demonstrates an increased risk in total and cardiovascular disease mortality in people consuming at least two NNS-sweetened beverages per day. While these findings are interesting, they are difficult to interpret as NNS are typically consumed more often by those whose cardiometabolic health is already compromised. Despite this, evidence from animal studies, including that delivered by our own consortium, indicate that NNS have the potential to disrupt normal metabolic and vascular function, events that are primary in the development of obesity, insulin resistance and cardiovascular disease. Indeed, rather than benefiting us, the impact of consuming NNS may be as bad on human health as the effects of excess sugar consumption. To bridge the findings from epidemiological and experimental research, this Standard EF will, for the first time in vivo, in humans, assess the metabolic and vascular effects of consuming NNS habitually; via a prospective, placebo-controlled, randomized, three-period crossover study. This research will also provide information about the role of type 1 sweet taste receptors (T1Rs), as well as oral sweet taste perception, in any potential NNS-mediated vascular/metabolic dysfunction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Trace metal and phosphate extraction from sediments and soils' in the context of a Fourth Framework call.

assistant: **Objectives**

Operationally-defined procedures (single or sequential extractions, leaching tests) are increasingly used for the evaluation of the mobility and bioavailability of contaminants (and related toxicity or nutritional capacity), and their potential risk for the environment. This approach has been widely used in soil studies for e.g. the prediction of agricultural crop deficiency or the assessment of toxical impact (contamination of groundwater through soil leaching); sequential extraction schemes have also been widely applied to sediment analysis to study the mobility of heavy metals and their adsorption pattern, as well as to study risks of eutrophication of lakes. However, the lack of harmonisation of these schemes does not enable results to be compared which render difficult any attempts to evaluate environmental risks. The European Commission (through the BCR programme) has contributed to the establishment of common methodologies which were tested and accepted by expert EU laboratories for soil (single extraction) and sediment (sequential extraction) analysis. Much remains to be done, however, to improve these schemes which are prone to errors owing to their heavy handling procedures.The project aims to improve existing single and sequential extraction schemes used for soil and sediment analysis for heavy metal monitoring and to compare existing sequential extraction schemes used for the determination of forms of phosphate in order to develop standardized procedures for their possible implementation as standards.The first phase of the project has consisted in testing various parameters (e.g. effects of pH, shaking speed, temperature) in order to establish common protocols (single and sequential extractions) to be tested in interlaboratory studies of which the results we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Transatlantic Slave Trade and the Development of Europe' in the context of a Horizon Europe call.

assistant: **Objectives**

AbstractFrom the sixteenth to the nineteenth centuries, slave traders of mostly European origin violently transported more than 12.5 million African men, women, and children to the Americas. This was the largest forced transoceanic migration in human history. Scholars have focussed on the effects of this migration on African and American history, while treating the slave trade’s effects on European societies as marginal. This supposition of marginality stems from two biases in existing research: a focus on the companies and individuals who directly outfitted slaving voyages instead of on the far larger group of people who invested in these voyages, and an over-emphasis on slave trade profits, leaving out many other relevant indicators of the economic, political, and cultural significance of slave traders. The trans-Atlantic slave trade and the development of Europe project (TASTADE) will correct this imbalance by identifying thousands of men and women who financed the slave trade and scrutinizing their embeddedness in their local, regional, national, and transnational contexts, to answer the following research question: How did the investors in the trans-Atlantic slave trade based inside and outside Europe shape the economies, politics, and cultures of Europe? TASTADE will transform existing scholarship by delivering a ground-breaking assessment of the national and trans-national networks that facilitated this trade and by linking these networks to key aspects of European development. In realising this overarching objective, TASTADE will reshape our understanding of the history of capitalism, colonial and commercial politics, and European culture. Our unique pan-European perspective relies on the distinctive synergy of approaches provided by the members of the core rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Investment Migration: Patterns, Natures, and Trends' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Foreign direct investment (FDI) flows are conducted by INDIVIDUAL investors (abbreviated as IFDI), which have been strongly promoted by Immigrant Investor Programs (IIPs). Twenty-one out of twenty-seven of the member states of the European Union (EU) establish IIPs to attract wealthy investors in order to receive investment capital; change the economic structure and social status of undeveloped regions, make a name for the country on the international market, and as an economic diplomacy strategy. While the FDI motivations of enterprises have been extensively studied; the motives of IFDI remain undeveloped. This limitation is certainly a missing puzzle piece in the scientific world, causing a lack of a theoretical basis to explain a real phenomenon. Simultaneously, demand-side motive ambiguity might impact the design of IIPs, leading to their inefficiency. Governments also lack a base to take a consistent stance on IFDI. This proposal aspires to provide a scientific and practical basis to fully understand the variation of IFDI, thereby aligning policy with its evolution. The overall aim is to develop the patterns of IFDI, its nature, and trends. Qualitative research methods with a variety of tools, mainly based on naturally occurring data associated with the opinions of the participants - knowledge co-producers. Two theoretical frameworks are developed: IMS12 to identify the drivers and nature of IFDI and VIRA to forecast IFDI. The results of this project, in addition to fulfilling its own objectives, will also serve as the foundation for further research in several scientific fields such as economics, sociology, and politics.This project is expected to run for 24 months and is hosted by the University of Malta in Malta, including a 4-month secondment at the University
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Diagnostic and Drug Discovery Initiative for Alzheimer’s Disease' (D3i4AD) targeting Seventh Framework.

assistant: **Abstract**

Alzheimer’s disease (AD) is the major cause of dementia which has no cure at the moment. The overall aim of the work described in this proposal is to create a long-term strategic partnership between Sheffield University (UK), Lisbon University (Portugal), Eli Lilly (UK) and Biofordrug (Italy) in order to develop chemical biology tools for better understanding the role of PrPC in AD and harnessing this understanding to develop novel chemical entities for diagnostic and therapeutics applications.The D3i4AD project brings together a consortium of groups with internationally-leading expertise from academia and industries in chemistry, molecular design and modelling, biochemistry, diagnostic and drug development. Our proposed programme will lead to major increases in the knowledge and capacity of all consortium members, achieved through significant intersectoral exchange of personnel between the partners over the duration of the project (total 134 person months) and through temporary recruitment of 5 new experienced researchers (total 114 person months). The project will thus underpin a substantial programme of intersectoral knowledge transfer and research training and lead to significant innovation and advances in several areas of basic research as well as diagnostics and therapeutics development. These activities will strongly enhance EU standing and international competitiveness in this extremely challenging and increasingly important technological area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Automotive Production Engineering Unified Perspective based on Data Mining Methods and Virtual Factory Model' (AUTOUNIMO).

assistant: **Innovation**

AutoUniMo consortium gathers academic and industrial partners for which modern methods used in production systems are the critical path of their activity. Industrial partner Continetal is recognized by drivers as a tire manufacturer, but few people know that it is also an important producer of automotive electronics.  Conti Temic microelectronic GmbH (CONTI) is specialised in design of advanced sensing and control devices for automobile. CONTI cannot get a sustainable position on the automotive market without effective informatics system that supports the short series production. Industrial partner AIUT is SME company that supplies machines and systems for automotive production. AIUT cannot operate in a highly competitive environment without advanced engineering solutions which not only fulfil functional requirements  of the customer but also ensure the efficient production. Nowadays, cheaper sources of raw materials and availability of cheaper labour cause that automotive production moves from Europe to the developing economies. European automotive manufacturers are beginning to lose their advantage. This causes negative impact on the European economy and reduces the number of employees associated with automotive industry. AutoUniMo academic partners will help to solve these problems by applying modern engineering and informatics methods  that will support industrial partners in their critical paths defined above. Institute of Informatics, Silesian University of Technology (SUT) has advanced research activity in Data Mining and in Artificial Intelligence areas. Hochschule Ingolstadt,  Faculty of Mechanical Engineering (HI) has large experience in the automotive industry, supported by many realised research projects with main focus on automotive industry.  AutoUniMo con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The roles of 3-kinase isoforms in cell migration' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Phosphoinositide-3 kinases (PI3Ks) are a family of signal transducing enzymes that regulate a wide variety of cellular responses such as growth, proliferation, survival, cytoskeletal changes and cell migration. Deregulated PI3K signalling is implicated in cancer, inflammation and diabetes, and intervention with PI3K signalling is being pursued by the pharmaceutical industry. Mammals have 8 distinct PI3K isoforms, the individual roles of which are not well understood. Clinical intervention with PI3K signalling will almost certainly have to be targeted at individual isoforms, given the risk that global alteration of PI3K signalling will be deleterious to the organism. It is therefore critical to understand the roles of the PI3K isoforms at the cellular and organismal level.This project aims to create and validate a leukocyte model system in which specific PI3K isoforms have been genetically inactivated and to delineate the functions of PI3K isoforms in vitro cell migration and signalling. More specifically, this project aims to derive primary and immortalised macrophages from gene-targeted mice in which PI3K isoforms have been inactivated in a constitutive or conditional manner, and to phenotypically characterise these cells, addressing the following important fundamental questions in cell biology and signalling:1. which signalling programmes are controlled by individual PI3K isoforms?2. which PI3K isoforms are critical for cell migration?3. do specific PI3K isoforms control cell polarity?This postdoctoral training period will allow me to train in important areas of cell biology and signal transduction, and allow to familiarize myself with advanced and unique approaches used by the Host Laboratory, including mouse gene knockouts and sophisticated cell biology and biochemi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Using Omics Techniques for Hydrocarbon Prospecting' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The proposed PROSPECTOMICS project intends to develop a radically new approach to Hydrocarbon (HC) prospecting based on molecular biological techniques. PROSPECTOMICS is the first project that utilizes the full potential of recent advances in so-called next-generation sequencing (NGS) with respect to hydrocarbon prospecting. Only the very recent developments in sequencing technology and the massive reduction in cost allow such a project to be carried out at an informative scale, which would have been unthinkable less than 10 years ago. PROSPECTOMICS brings together vastly different fields (Biogeochemistry, Metagenomics, Metatranscriptomics, Metaproteomics, Bioinformatics, Machine Learning) and uses their individual strengths to complement each other in order to develop a completely novel approach that has the potential to challenge current technical paradigms. The PROSPECTOMICS consortium consists of six groups from four countries, each an expert for one specific technology. Partnership with a petroleum exploration company guarantees a direct connection to real world conditions and uniquely offers the opportunities to immediately to field-test the hypotheses generated. Despite ongoing efforts to increase the percentage of renewable energy resources, HC will remain an important energy source for several decades. One of the key factors to reach EU’s ambitious goals in reduction of greenhouse gas emissions is the replacement of coal by other energy sources, mainly natural gas. Additionally, increasing global competition for resources and rising energy prices as well as price differentials between the European Union and its competitors requires energy which is sustainable, affordable and with a secure and reliable supply. Exploration for new resources within the EU are a ke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Atm switch for integrated communication, computation and monitoring', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The implementation of a European, single-chip, gigabit ATM switch that is a general-purpose building block for high-performance communicationThe development of the architecture of this switch for the efficient support of a broad range of services, both in public, wide and local area networkingThe implementation of a gigabit ATM testbed, and the demonstration of gigabit ATM switches integrated and operating inside themA single-chip 16-by-16 ATM switch at 622 Mbit/s per link (aggregate throughput of 20 Gbit/s)A serial link transceiver operating at 2.5 Gbit/sA demonstrator 16-by-16 ATM switch at 622 Mbit/s per linkUpgrade of an existing 155 Mbit/s ATM testbed to 622 Mbit/sExpected ImpactThe successful implementation of the project's objectives will contribute significantly to the enhancement of the competitiveness of the European Telecommunications and Information Systems Industry, since there is no known single chip ATM switch available in the international market. The chip that will be implemented can be used for the development of larger telecommunications ATM switches, capable of handling the huge amounts of data required for the implementation of the information highways. Additionally, it will allow the development of faster and lower-cost local area ATM networks, which, among others, will enable affordable parallel processing using workstation clustering.Main contributions to the programme objectives:Main deliverablesA Single Chip ATM switch (ATLAS I) having an aggregate throughput of 20 Gbps and a Serial Link Transceiver capable to handle 2 Gbps of data. A demonstration ATM switch and a relevant ATM testbed was also implementedContribution to the programmeAllows the development of faster and lower-cost local area ATM networks.Technical ApproachThe target of the ASIC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MANUFACTURING AND VALIDATION OF INDUSTRIAL PROTOTYPES OF BIAXIAL CREEP AND SHEAR TESTING MACHINES' (1994-1998).

assistant: **Concept**

The project built on the advances made in earlier EU funded Brite Euram projects to develop commercial prototypes of two types of materials testing machine (compression /tension and shear testing), which could be utilised under different temperature conditions. The objectives were to improve the design of the laboratory prototype machines and develop these into full commercial prototypes that could be validated and allow market assessments to be made. The project involved testing a range of different materials and the incorporation of feedback from the user interests in the consortium to develop the machines. Marketing assessments were made through trade exhibitions, literature, video and CD Rom. A patent application to the EPO was successful. The main constraint would appear to be the lack of sufficient manufacturing quality for the design of the commercial prototypes. At the completion of the final report, there was considerable further work to be done to ensure successful marketing.The project aimed to develop industrial prototypes of the two testing machines for commercialisation. In this respect, a consortium including IMMG and a company called TNC Electronics provided the required sensors/controls and implemented them on the industrial version of the machines. In addition universities in materials research and equipment design (Imperial College, TU Clausthal) and a Ceramics-Refractory Company (CERECO S.A.) contributed to the validation of the industrial prototypes both by providing the necessary specifications for different categories of materials testing (composite, metals, ceramics) and by performing tests on an industrial scale with realistic specimens. Modifications of the loading train, extensometers, control systems etc. for each category of materials were a