RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Energy Conversion and Information Processing at Small Scales' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Thermodynamics provided mankind with the intellectual tools to master energy transfers and energy conversion in macroscopic systems operating close to equilibrium. It is now one of the most fundamental theories in physics. My goal is to establish a thermodynamic theory describing energy conversion and information processing in small synthetic or biological systems operating far from equilibrium. Significant progress has been achieved in this direction over the last decade. The new theory is called stochastic thermodynamics (ST). It allows us to describe and understand energy conversion in systems as diverse as quantum junctions and molecular motors, and also to predict the energetic cost of information processing operations such as erasing bits of information or feedback controlling a small device. It was validated in single molecule pulling experiments, electronic circuits, NMR and colloidal particles in optical tweezers. Nevertheless, ST still suffers from serious limitations which prevent its application in more complex systems. Therefore, I propose to expand the theoretical foundations of ST far beyond its current realm of validity and to broaden the scope of its applications in various new directions. I want to answer questions such as: Can one design devices made of many small energy converters (e.g. thermoelectric junctions) arranged in such a way as to generate collective behaviors (e.g. synchronization) prompting higher powers and efficiencies? Can one do the same by engineer quantum effects? How can one reduce the dissipation occurring when computing very quickly with small devices? Why are metabolic networks so efficient in converting energy, transmitting information, and preventing errors (e.g. toxic byproducts)? I will do so in close contact with leading ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NOVA Institute for Medical Systems Biology' in the context of a Horizon Europe call.

assistant: **Objectives**

The rise of chronic diseases is shaping health policy priorities worldwide. As the population ages, these conditions affect increasing portions of society and are more difficult to manage, causing suffering in patients and their families for many years. Such increasing prevalence is a threat to the sustainability of healthcare systems. Thus, an increasing focus has been put on disease prevention and awareness, as well as on precision medicine. This project will create a new Centre of Excellence, NOVA Institute for Medical Systems Biology (NIMSB), which will use the most advanced cell analytics and experimental in vitro systems, combined with computational approaches to understand and fight chronic diseases. The core of the project will be the integration of multi-omics data from single cells from patient biopsies and derived organoids, bioinformatics and artificial intelligence, cell and molecular biology, and relevant animal model studies, to develop quantitative models that can inform on mechanisms of disease progression. Researchers and clinicians will collaborate to use this knowledge to implement novel precision medicine solutions, aiming to intercept diseases before symptoms develop, and also by improving diagnosis, disease course prediction and response to treatment. NIMSB will contribute to clinical practice improvement not only with technology but also by training the next generation of researchers and medical doctors in precision interceptive medicine and digital-transformation technologies. NOVA Medical School of NOVA University is in a unique position to coordinate the project due to its current drive for restructuring, established reputation as a top Medical School in Portugal, and research focus on chronic diseases. The Max Delbrck Center for Molecular Med
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Boosting future careers, education and research activities in the European bio-based industry' (UrBIOfuture) under Horizon 2020.

assistant: **Objectives**

UrBIOfuture main goal is to bring Europe to the forefront of the bio-based sector by boosting careers, new educational programmes and research activities.This approach is intended to be developed in this project as a 3-step methodology:(1) An identification step, involving career mapping of programmes involving bio-based activities and pointing of skills mismatch between them and the bioindustry needs as main KPIs, alongside with a previous methodology and work terminology developed and aligned between the educational sector and the industry needs. (2) An interaction step, in which the constant contact and contributions of the education sector, academia and industry will be sought throughout the project. The KPIs involved will be (a) building a comprehensive stakeholder network and a working group involving representatives from each sector of the bio-based value chain. The project has already received the support of 72 organizations from bio-based industries (38 LOIs), educational institutions and networks (15 LOIs), and from innovation and research centres (19 LOIs); and (b) the organisation of two workshops in which this group will participate. The first will seek dialogue between the different profiles to validate the common terminology and methodology, and the second will consist of a co-creation exercise to set the basis for promoting careers in the bio-based sector. (3) The implementation of UrBIOfuture, through an appropriate Communication and Dissemination plan; the organization of promotional events, train-the-trainer and train-the-student workshops; and the development of an afterlife plan will ensure the broader impact of the results materialised in the project among the European bio-based sector.The results of UrBIOfuture will help building a bio-based indus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A smart, hybrid neural-computo device for drug discovery' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

NEUREKA will bring a paradigm shift in drug discovery for neurological diseases, a sector that suffers multiple, repeated failures exacerbating the economical and societal burden of these incurable diseases. It will do so by addressing a crucial shortcoming: the lack of in vitro systems faithfully reproducing brain pathology that enable the functional assessment of candidate compounds at multiple levels: from synapses to neuronal circuits. NEUREKA introduces an innovative, hybrid technology, whereby detailed, computational neuronal networks simulate dysfunction and drive cultured neurons to replicate in-brain disease conditions. Nanoelectrodes mediate the transmission between simulated and biological neurons. Akin to real synapses, nanoelectrodes contact cultured neurons at subcellular locations across the dendritic tree, soma and axonal branches, allowing to control and monitor neural activity with unprecedented accuracy. Biological neuronal responses registered by nanoelectrodes are fed back to simulated neurons, closing the loop and enabling control of activity states across the hybrid population. Complementing molecular deficits already present in culture models of a disease, computational models enable replication of both molecular and physiological deficits of neurodegeneration in vitro. Cultured neurons are driven towards pathological excitability states where deficits emerge, so as to optimize quantification of the impact of drugs, going well beyond standard cellular assays. A proof-of-concept will be provided for Alzheimer’s disease, using human induced pluripotent stem cell (iPSC)-derived neurons exhibiting the pathology. NEUREKA will be used to demonstrate the effect of drug candidates across synaptic, neuronal and network functions.


**Keywords:** neuroelec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Predicting speech: what and when does the brain predict during language comprehension?' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The ability to recognise spoken words relies on extracting phonological features from the acoustic input that distinguish a word from its cohort competitors. Neuronal circuits were suggested to use context to predict and pre-activate specific speech features. Bottom-up feature recognition is enabled by phase and amplitude coupling between cortical oscillations and acoustic signals and this process is facilitated by top-down predictive processing. Predictions may be critical for the speed, accuracy and noise resistance that distinguish fluent speech recognition and were related to specific cortical oscillatory patterns (theta/delta synchronisation, beta increase). Despite evidence, the nature and the timing of these predictions remains unclear. This project will address these key questions using MEG and EEG that provide good spatiotemporal resolution. Increasing predictability of a word should have two effects: A) Neuronal populations encoding its phonological form will become active before this word is uniquely identifiable from its potential competitors by bottom-up analysis (uniqueness point UP). Using spatiotemporal multivariate pattern analysis we will test if the latency of phonological feature detection, used for word identification, is modulated by word's contextual predictability. If specific predictions are made, divergence should occur before the UP and should be supported by changes in oscillatory activity; B) Generating predictions should decrease bottom-up feature processing demands. We expect predictability to reduce the phase-amplitude coupling between the speech envelope and the gamma oscillations (a neuronal measure of phonological processing). In summary we aim to identify whether and how context enables predictions of incoming words’ form before it ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Geodynamics of oblique subduction orogens' to be submitted under Fifth Framework.

assistant: **Abstract**

This research aims to determine the fundamental controls on deformation styles, fault and strain partitioning in oblique subduction orogens. This multidisciplinary programme will combine field, remote sensing, and thermo chronological and potential field studies with scaled analogue modeling of oblique subduction systems. The field research will focus on northern Chile where oblique subduction of the Nazca plate has produced a complex cordilleran orogen that includes strike-slip, thrust and inversion faulting as well as major porphyry magmatism. Field studies will include transects through both the Coastal Cordillera (Atacama fault system) and Cordillera Domeyko, structural analysis sampling for fission track, Ar/ Ar and U/He dating. Laboratory studies will include analysis of Landsat TM images, interpretation of gravity and aero magnetic data, section reconstruction in 2D and 3D, and physical modeling utilizing large sandbox models of oblique subduction systems. In this manner we aim to develop 4D models for the evolution of oblique subduction systems and their fault and strain partitioning and magmatic history. In particular the focus on northern Chile will have significant impact on models for the development of porphyry Cu-Au systems in this region. The applicant will be trained in 2D and 3D section balancing and reconstruction, interpretation of Landsat lata, interpretation of aeromagnetic and gravity data and scaled physical modeling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Strategy and methodology for improved IWRM - An Integrated Interdisclipinary Assessment in Four Twinning River Basins in Europe and Asia' (STRIVER) under Sixth Framework.

assistant: **Objectives**

The point of departure for STRIVER is the lack of clear methodologies and problems in operationalisation of IWRM as pointed out by both the scientific and management communities. STRIVER will develop interdisciplinary methods to assess and implement IWRM. Based on the development of a multidisciplinary knowledge base assessment in all case studies (policy, social and natural sciences) and an early stage development of IWRM conceptual framework, the project will undertake IWRM in the four selected twinned catchments covering six countries in Europe and Asia.Twinning activities based on a problem-based approach will be performed in four case river basins:- Tunga Bahdra (2 states in India),- Sesan (Vietnam/Cambodia),- Glomma (Norway),- Tejo/Tagus (Spai n/Portugal)Under the IWRM framework, the problems to be covered are:(i) water regimes in transboundary regulated rivers,(ii) environmental flow,(iii) land and water use interaction, and(iv) pollution.The research will use sub-basins of each river basin in all cases to allow more detailed studies and easier integration of all stakeholders, for transferability purposes. STRIVER will contribute towards improved interdisciplinary IWRM, based on the coupling and balancing of ecological, social-economic and policy variables in all the four case-basins by twinning activities.To that end, the project will:- develop guidelines for interdisciplinary methods to assess and implement IWRM- assess the transferability of case study results- enhance the dialogue between decision-makers, stakeholders and scientists- disseminate data and information to stakeholders to promote participatory planning and integrated decision-making, taking adequate account of the rights of poor people and gender roles- ensure that project results will benefit al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrating Pedagogically-Documented, Value-Added E-Training Add-Ons in Commercial Software Products of European Software SMEs'.

assistant: **Objectives**

The 24-month ELEVATE project proposes a hybrid training and certification environment, which integrates the application software to be taught in the pedagogical-documented educational process, allowing the software development SMEs to deliver innovative e-training services and to address (more than adequately) the needs of their business partners and customers. Thus, the ELEVATE project addresses the business needs of the software development SMEs participating in the project in the field of application software training through their business partners and customers networks. As the software development SMEs have restricted resources to allocate in research and development (R&D) activities with regard to secondary corporate objectives, including e-training in the produced application software products, the proposed ELEVATE project provides participating SMEs with potentials and financial support to outsource a critical mass of research and technological development (RTD) activities to industrial companies and universities with larger research capacity and proved, successful experience in R&D, European-wide initiatives. The ELEVATE RTD performers will undertake significant research activities on behalf of the participating SMEs and deliver technology know-how in the fields of e-learning, educational content aggregation and material creation, learning management system and application software integration, and pedagogic standards and models. Led by CAS Software AG, the consortium consists of 8 partners from 7 EC member and associated countries (Germany, Belgium, Swiss, Greece, Cyprus, Italy and Turkey), including software development SMEs, industrial companies and universities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Uncovering Protective Mechanisms in Pancreatic β-Cells to Enhance Their Survival in Type 1 Diabetes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of pancreatic β-cells, leading to insulin deficiency and severe complications, including cardiovascular disease, neuropathy, and vision impairment. Despite extensive research, the exact cause of T1D remains elusive, and the disease remains incurable. Emerging evidence suggests that β-cells may play an active role in their own demise, alongside the well-documented immune attack. Recent findings have identified protective genes within β-cells that may help them resist immune-mediated destruction.This project aims to investigate the role of three protective genes—HLA-E, IDO1, and BiP—in preserving β-cell function and survival under autoimmune stress. These genes were identified via a bioinformatic approach that analysed single cell RNA sequencing of β-cells from individuals affected by T1D. The study will begin by modulating the expression of these genes in human EndoC-βH1 cells and human islets, followed by an immune attack model of co-culture with the activated CD8+ T-cells. The goal is to determine which gene(s) offers the most significant protection against β-cell destruction.Subsequently, the most promising gene(s) will be further evaluated in stem cell-derived β-like cells, which will undergo in vivo testing in immune incompetent NSG mice to mimic more physiologically relevant conditions. The implanted cells will be evaluated by in vivo imaging using an intravital microscopy platform. By silencing or overexpressing these genes, we aim to elucidate the mechanisms that contribute to β-cell resilience, providing insights that could lead to novel therapeutic strategies for enhancing β-cell survival in T1D patients.This project represents a critical step forward in understanding the int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Automatic Mapping of Fibre Orientation for Draping of Carbon Fibre Parts', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This project aims at the development of an automatic quality control and feedback mechanism to improve draping of carbon fibres on complex parts. There is a strong need in the automotive industry for automatic systems that perform quality control and improve draping processes in order to allow high production volumes.The technology that is being developed in the project will include a new sensor system for robust detection of fibre orientation combined with a robotic system to scan complex parts. This is based on a new technology that uses reflection models of carbon fibre to solve the problems encountered with earlier vision-based approaches. The data coming from the inspection system will be fed into draping simulation to improve the accuracy of the processes. Draping is the process of placing woven carbon material on typically complex 3D parts (preforms) with the goal of having the fibres oriented along specific directions predicted by finite element calculations. This is done to maximize the strength-to-weight ratio of the part.There is a strong trend in the automotive industry towards lightweight parts to increase fuel efficiency, also considering the needs of electrical vehicles. Setting up the draping process for a complex part takes up to 50 preforms for trial-and-error improvements. Current production processes are thus not yet adequate to cover the expected volumes of several 100.000 parts per year. The project aims at shortening process development times by 90% and allowing automatic 100% quality control of fibre orientation.The industry-led consortium consists of European key partners in draping simulation, manufacturing of carbon parts for the automotive industry, sensor developers and robotic experts. It is complemented by a group of interested end users,