RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sustainable Human Development for MED Countries' under Seventh Framework.

assistant: **Concept**

The SHuMED project proposal is aimed to support and strengthen the different existing collaboration actions between Europe and Mediterranean Partner Countries (MCP) for research and research training in the field of the sustainable development and the relating monitoring initiatives, thanks to the staff exchange opportunities offered by IRSES. This multidisciplinary exchange programme aims at propose a corporate-view approach for measuring the level of human development in sustainability terms by considering the contribution of corporates and their networks.The programme has 5 Work Packages. WP1 (‘management’) will define the management structure of the project. WP 2 (‘methodologies’), through the expected 4 Training Activities in the 4 target MCP Countries, will develop the Sustainable Human Development Index (SHDI). In this work package, starting from the SHDI macroeconomic model and thanks to the research and to the knowledge transfer coming from the training sessions in MCP, processes of joint learning and coevolution will be analysed. WP 3 (‘case studies on human development’), strictly connected with WP2, will analyse some case studies in Europe, thanks to the numerous visits foreseen in Italy and Spain. These case studies will support the analysis of  processes that could affect research practices in the area of sustainable human development and corporate social responsibility. Associated partners that will support the project in EU Countries will be the target users of this SHDI (not only using but also contributing in enhancing the index). The WP4, with its reporting activities, will contribute to analyse the dynamic capabilities of SMEs within networks and clusters in order to develop a tool for enhancing and monitoring them. The final WP 5 (‘communication and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Low Coordinate Transition Metal Single Molecule Magnets' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Fellow, Maialen Espinal (MEV) from the University of Bath, outlines a case for support to work alongside the Host, Prof Mike Whittlesey (MKW: University of Bath, UK), on the design of novel two-coordinate complexes of Ni, Co and Fe as single molecule magnets (SMMs).The rationale for the work is the 2013 report by the MKWs group of a cationic Ni(I) N-heterocyclic carbene complex that exhibited the first example of SMM behavior observed in a mononuclear Ni complex. SMMs are the focus of considerable multidisciplinary investigations because of their potential for high-density information storage and quantum computing. Most work until now has focussed on lanthanides, but there has been an increasing realisation that organotransition metal derived SMMs may offer significant benefits in terms of their ability to stabilise different electronic environments as a result of being able to adopt unique coordination geometries. MEVs approach will be to use large ring NHC ligands and probe the influence of ring size, substituents, coordination mode and resulting molecular geometry on magnetic behaviour. The project will utilise the research experience of the applicant in synthetic chemistry to make new compounds in Bath, but most importantly, provide her a unique opportunity to develop new skills for progression of her career by exposure to new techniques and methodologies through periods of secondment to internationally leading laboratories for studies of magnetism (Prof Annie Powell (AKP), Karlsruhe, Germany), paramagnetism via Electron Paramagnetic Resonance (Prof Damien Murphy (DMM), Cardiff, UK) and computational chemistry (Prof Stuart Macgregor (SAM), Heriot-Watt, UK).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Designing therapeutic protein-protein inhibitors for brain cancer treatments'.

assistant: **Innovation**

Protein-protein interactions are central elements in cellular processes and important targets for selective therapeutic agents. They constitute a rich area for discovery of novel small ligand-based therapies.This proposal seeks to utilise such interactions, in particular those featuring an alpha-helix binding groove, such as p53-MDM2, or more novel targets e.g. n23-prune to develop targeted small molecule libraries with physico-chemical properties appropriate for therapeutic effect against various tumour types such as the brain cancers of glioblastoma and medulloblastoma. Combination of the concepts below should provide an opportunity to unlock the potential of protein interactions as key components in signalling pathways via design of selective small molecule modulators targeting the kinase-effector interaction instead of the ATP active site.Data-mining of ADME and drug-drug interactions to build a predictive database for library design.Develop quantitative structure/property relationships, with an emphasis on CYP-mediated metabolism,ABC transporters at the blood/brain and brain/tumour interfaces,mutagenicity, solubility, pKa,and passive permeability,and predictive tools for mutagenicity and other genetic toxicology end-points.Develop predictive PK and PBPK models to improve understanding of BBB and tumour penetration.In vitro and in vivo PK/PD and TK/TD characterisation of compounds, to increase understanding of their mechanism of action and reduced the use of laboratory animals.Develop an understanding of the elements controlling selectivity in protein-protein signalling networks by developing approaches for design of small molecules that target alpha-helix binding groove interactions through use of structure based and fragment based approaches. Such knowledge-based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Family life and professional work: conflict and synergy' (FAMWORK).

assistant: **Concept**

The network of 7 European research groups intends to contribute to one of the core issues of modern family life and professional work in Europe. Modernisation implies antagonisms between the needs of family life and the professional work conditions. These antagonisms can have negative effects on several levels such as health, well-being and work productivity. The proposed project investigates the influences of external and internal resources, which facilitate the compatibility of family life and professional work. Variation over cultural areas will be of special interest. To analyse these issues, the project refers to different types of information such as official European figures, psychological data assessed within a longitudinal design and an innovative type of psychological information. The development of applicable instruments and resulting evidence are basic requirements for guiding future policy making.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Working in a Collaborative Factory of the Flight Simulators Branch of RISE' under Horizon 2020.

assistant: **Concept**

The research programme of WrightBroS project is aimed to develop a prototype of NewTechnology professional flight simulator to demonstrate how deployment of augmented reality (AR) has a potential to significantly broaden the market for these new products. The economical impact on market expansion will be achieved due to innovations at three layers: (1) technological support to “learn as you go” paradigm, (2) developing AR-based virtual maintenance and servicing system, and (3) AR-based architecture of the flight simulator (as opposed to current architectures based solely on virtual reality). Research leading to these innovations will be performed by collaborative teams from Silesian University of Technology (PL) and two HighTech companies: LG Nexera (software development company from AT), and VRM (flight simulators manufacturer from SK). Such composition not only will mobilise to the project the researchers with complementary skills but also it will provide to WrightBroS project the equipment of exceptional in Europe Virtual Flight Laboratory at SUT, resources for complex data management at NXR, and professional industrial environment for manufacturing flight simulators at VRM. Working toward attainment of scientific goals in this multidisciplinary project will rely on advanced image processing, pattern recognition, knowledge acquisition and processing, smart diagnostics methods, augmented reality technology, and aerodynamics simulation models. Common goal to achieve the qualitatively new technology will be a basis for a rich programme of mutual staff training not limited only to secondments. Particular attention will be paid to wide and efficient dissemination and communication. Due to these measures, WrightBroS project will strengthen career perspectives of participat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advancing neuroscience by imaging BRAin Cortical fibErs' to be submitted under Horizon Europe.

assistant: **Abstract**

MRI provides the unique opportunity to investigate the relation between brain structure and function non-invasively, which is key to understand the functioning of the brain and unravel disease processes. An important technique is diffusion MRI (dMRI), which allows to reconstruct the structural connections through which brain structures communicate. Conversely, no technique can reconstruct the internal wiring of brain structures such as the cortex in living humans, where cognitive functions are processed, hindering scientific and societal progress. To achieve this, three challenges must be overcome: a spatial gap of an order of magnitude between (d)MRI and the cortical circuitry; insufficient contrast provided by (d)MRI in the cortex; and a lack of appropriate models to characterize cortical circuits.I aim to bridge the gap between structure and function by mapping the fibers of the brain cortex non-invasively for the first time, which are expected to be affected by neurodegenerative processes, and to be closely related to cognitive decline. To achieve this goal, I will pioneer a synergistic approach combining my expertise (dMRI acquisition and modelling), with unique acquisition hardware designed at our institution. First, I will establish a novel multidimensional acquisition combining dMRI with MR relaxometry, together with a signal model tailored to characterize axonal fibers in the cortex. Next, I will leverage state-of-the-art hardware and super-resolution approaches to push the boundaries of in-vivo MRI by an order of magnitude (to the mesoscale). This will unveil cortical fibers in living humans for the first time, and allow us to explore their properties in patients with Alzheimer’s disease, their changes during ageing, and their relationship with cognitive funct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Network of EUROpean funding on Neurological research' (NEURON), addressing dissemination and exploitation.

assistant: **Impact**

The consortium realising NEURON comprises the Fonds National de la Recherche (Luxembourg), Ministry of Scientific Research and Information Technology (Poland), Chief Scientist Office of the Ministry of Health (Israel) and Projekttraeger im DLR (Germany, co-ordinator). The SSA aims to prepare an ERA-NET linking European national and regional research funding programmes in the field of disease-related neuroscience. Among the many diseases affecting health, neurological disorders are major causes for impaired quality of life, and over one billion people world wide suffer from them. The thematic priorities of the funding programmes involved in the SSA will be on neuronal degeneration and neural repair. Measures shall be taken by the consortium to develop a network and to lay the foundation for further extension of network activities. A platform for partnering and networking of funding organisations in EU member states and associated or candidate countries will have beneficial effects for the integration of research policies and creation of a European Research Area. Consortium members shall exchange information on existing national programmes. By sharing experiences on procedures and best practices in each partner organisation this will induce a mutual learning process. The consortium will discuss and identify topics of common interest that shall undergo a more detailed benchmarking process in a future ERA-NET. They will develop and implement efficient governance and communication structures to gradually grow into a functioning network with sufficient flexibility for extension. Suitable additional partners shall be identified by compiling knowledge about European governmental and private funding bodies in the area of neurological research funding. Potential new partners shal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A detailed study of the chemistry, physics, and structure in AGB stars' to be submitted under Seventh Framework.

assistant: **Abstract**

The proposed research will form a comprehensive study of the chemistry and structure of evolved stars on the Asymptotic Giant Branch (AGB) and their circumstellar envelopes (CSEs), and form a powerful basis also to study the origin and evolution of heavy elements in galaxies, and the effect of AGB evolution on the formation of stars and planets. The focus of the proposed research is on the chemical properties of AGB stars and their CSEs, and on the structure and dynamics of the mass loss that creates the CSE. The project builds on the knowledge I have on AGB stars, and makes use of the observational and modelling tools I helped develop in the past years. I will describe the chemical complexity of AGB CSEs through the analysis of existing and future data, in observations with both a broad frequency range and high-spatial resolution. I will be able to identify the typical chemical reaction paths in the CSE and set constraints on the chemical processes. I will further observe the 3-dimensional structure of AGB CSEs and detached shells, and for the first time observationally describe the process that leads to the chemical evolution of AGB stars. The analysis of the data will be done using 1D and 3D radiative transfer models and 3D hydrodynamical models. The proposed project fully explores the capabilities of the Atacama Large Millimetre Array in Chile, and the recently extended bandwidth of the EMIR receiver on the IRAM 30m telescope in Granada, Spain - two observing facilities with a large investment from Europe. The research will be carried out at Onsala Space Observatory in Sweden, an institute with a long history in radio astronomy, and significant experience in scientific areas directly related to the proposed research. Working in Onsala I will strengthen existing and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advancing Machine-Learned Interatomic Potentials for Proteins Simulation (MLP4ProSim): From Development to Application' (MLP4ProSim).

assistant: **Concept**

Atomic simulation of the proteins is one of the main tools in understanding the functions, interactions, and dynamics of these vitally important biomolecules and plays a pivotal role in numerous cutting-edge researches such as elucidating the pathways of diseases, drug discovery and so on. The limited accuracy of the classical force fields specially in approximating non-bonded interactions as well as in capturing kinetics of proteins has attracted attentions towards more advanced alternatives. MLP4ProSim aims to develop next-generation transferable all-atom machine-learned potentials (MLPs) for computer simulation of proteins. To assure the applicability of the developed potentials for more realistic and biologically relevant simulations, training of the MLPs is carried out using a critically assessed dataset containing both quantum-mechanically computed and experimentally determined reference data. Enabling transferability of the developed MLPs and their applicability for the simulation of different proteins without requiring demanding retraining processes will be addressed by considering training sets containing proteins with diverse shapes, functions, and sizes. The resulting MLPs, after being validated for reliability and transferability via extensive benchmark tests, will be implemented in LAMMPS as an extensively applied molecular dynamics simulation code to make it openly accessible to the community. The successful completion of the project objectives is expected to have significant impacts in a broad range of scientific and technological areas. In addition to the anticipated outstanding scientific impacts, this project encompasses comprehensive trainings planned for the experienced researcher Dr. Amin Alibakhshi in accordance with the objectives of the Horizon E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Evolutionary Dissection of the Neck Musculoskeletal System in Dinosaurs'.

assistant: **Concept**

In contrast to the clawed forelimbs of their dinosaurian ancestors, the highly specialized forelimbs of birds are exclusively adapted for flight which constrains their functional versatility. It is assumed that consequently the avian neck became the functional equivalent to an arm and great divergence is evident in number, form and function of the cervical vertebrae. Owing to methodological advances such as imaging techniques and computer technology, we only recently started deciphering the complex biomechanical adaptations of the neck in birds and the results serve as basis for bioinspired design including an arm for robots. The classic avian body plan was pieced together gradually over tens of millions of years of evolution rather than in one burst of innovation. Traits such as feathers, the furcula, and wings first evolved in the dinosaurian ancestors of birds, whereas other traits such as the pygostyle and a keeled sternum evolved in more derived birds during the Cretaceous. This raises the question of when and how has the highly versatile avian neck evolved? The EDDI team will address this issue by investigating the evolutionary mechanisms responsible for the diversification of the neck in archosaurs, the group of fossil and extinct vertebrates that includes dinosaurs, birds, and crocodilians. To do so, homologies of the skeletal and muscular system of the neck will be established using developmental and morphological data. This will serve as basis for the investigation of changes in the musculoskeletal system of the neck across phylogenetically diverse living and fossil taxa. Reconstructing these patterns among dinosaurs will provide new insights into how evolution drove major morphofunctional changes that underpinned their spectacular evolutionary success, in par