RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Novel tools to read and write the epigenetic code in inflammation'.

assistant: **Concept**

Chronic inflammatory diseases, such as, for example, asthma, afflict millions of people worldwide. Nevertheless, the molecular mechanisms that drive inflammation remain poorly understood. Enzymes play a crucial regulatory role in inflammation and represent potential drug targets. Nevertheless, the activities of these enzymes are poorly studied due to a lack of convenient tools for modulation and detection. The importance of this issue is demonstrated by my previous work on small molecule probes for protein palmitoylation. It becomes increasingly clear that the slow advance in the development of chemistry-based methods to study enzyme activity in its physiological context delays drug discovery.To address this problem further, I will develop novel detection methods and small molecule inhibitors to study inflammatory signal transduction pathways. Protein acetylations at lysine residues have a broad regulatory scope. Acetylations of histones form a major part of the histone code for epigenetic regulation of gene-transcription. In addition, reversible acetylations of non-histone proteins proved to be crucial for regulation of nuclear factor kB (NF kB) mediated gene transcription.I aim to study the role of acetylations of histones and other proteins in NF kB mediated gene transcription. Firstly, I will develop a novel bioorthogonal ligation strategy for chemical labeling of protein acetylation in cells (aim 1) by employing the oxidative Heck reaction. Secondly, I will be the first to systematically investigate changes in protein acetylation in response to activation of the NF kB pathway using a proteomics strategy (aim 2). Thirdly, I will develop small molecule inhibitors of acetyltransferases and study their impact on acetylations that regulate the NF kB signaling pathway (a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Automated software test environment for process automation in the steel industry'.

assistant: **Objectives**

The objective of the experiment is to put into practice an efficient, state-of-the-art test approach and environment, which is modular and thus scaleable to projects of different size but of similar base functionality and with similar requirements regarding reliability, maintainability, and safety. The experiment shall prove whether the application of software test methods and tools result in higher quality software systems, higher efficiency of the testing process ,and reduced efforts for installing and maintaining the target process and production control systems in the steel industry.THE EXPERIMENTThe test approach, consisting of a test concept and a supporting test and simulation environment, shall cover all system test phases starting from the factory test onto the final acceptance test. In particular, it is foreseen to provide several sub-projects within the baseline project with tools supporting the test specification, preparation, and performance on system level. Especially for the integrate engineers of the customer in the experiment from the very beginning. In a second step, the test environment will be extended by an efficient simulation system to allow to determine in advance the operational behaviour and the side effects due to changes in the plant configuration as well as in production The last step will be the introduction of the test and simulation environment at site for an even better integration of the end-user.EXPECTED IMPACT AND EXPERIENCEThe expected impacts are not only more efficiently tested applications, reduced installation time and cots, reduced down time, better maintainability and training facilities for the end-user, but also in general higher quality software systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Platelet LYSAte based DERMal formulation for the treatment of skin ulcers' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The LYSADERM project aims at the fabrication of a medicinal cream containing Platelet Lysate (PL), that can be used for the topical therapy of skin ulcers. The applicant company Episkey is an innovative start-up founded in 2016 with the aim of introducing into the market novel therapeutic products obtained from human Platelet Lysate. Episkey holds the exclusive licenses of international patents covering the therapeutic administration of cord blood Platelet Lysate, and already developed an international network of cord blood banks aimed at the procurement of Cord Blood Platelet Lysate for pharmaceutical transformation into platelet derivatives and drugs.  Within the broad scope of our company mission, the LYSADERM project aims at marketing a novel formulation of dermatological cream containing tissue regenerative factors present in human platelets. The LYSADERM dermatological cream will be therefore used for the treatment of skin ulcers, including serious disorders, such as diabetic foot ulcers, pressure ulcers and leg ulcers.  LYSADERM aims to be the first pharmaceutical cream containing Platelet Lysate, and it is expected to improve healing of the ulcers in comparison to conventional treatments, at lower cost; therefore, it would become the standard procedure to treat diabetic foot ulcers, pressure ulcers and leg ulcers. The LYSADERM business project is expected to generate positive outcomes for the whole society, such as the increase of effectiveness in the treatment of skin ulcers both in hospitals and at the patient’s home. It is roughly estimated that once industrialized, LYSADERM can generate in just 5 years a total of over 10 M annual revenues, covering the 0.4% of the EU market share.  Overall, the main objective of our phase I project is to achieve the technica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NOVEL HIGH OXYGEN AND NOBLE GAS MODIFIED ATMOSPHERE PACKAGING (MAP) FOR EXTENDING THE QUALITY SHELF-LIFE OF FRESH PREPARED PRODUCE' (MAP), addressing dissemination and exploitation.

assistant: **Impact**

The key objectives of this project are :- to establish safe pre-competitive commercial applications of high oxygen MAP for extending the quality shelf-life of a wide selection of prepared produce items;- to investigate the underlying microbial and biochemical spoilage mechanisms which are inhibited under high oxygen MAP;- to provide a comprehensive guidelines document which will outline good  manufacturing and handling practices for high oxygen MAP as well as non-sulphite dipping of fresh prepared produce.In addition, this research will entail extensive investigations of the effects of high oxygen and argon MAP on the redox status, respiration rates, microbial growth, nutritional components (vitamins C and E, carotenoids, polyphenolics, quinols, and polyunsaturated fatty acids), energy metabolism, oxidative stress and oxygen driven product enzymes (polyphenol oxidase, lipoxygenase and peroxidase) of fresh prepared produce.High oxygen and argon MAP are radically new approaches to produce MAP. For example, high oxygen and argon MAP have very recently been found to significantly inhibit enzymic browning, anaerobic fermentation reactions, respiration rates, and aerobic and anaerobic microbial growth. Using such novel MAP approaches circumvent the many inherent disadvantages of current state-of-the-art produce MAP. Further details of these novel MAP technologies are outlined in Part A of this proposal.High oxygen and argon MAP have great potential to improve the competitive position of the European produce and prepared produce industries since the extra quality shelf-life achieved will enhance export potential with considerably less wastage, at a more economic cost. The involvement of SMEs has already been assured and these new MAP approaches can improve the added-value pote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Displacing Deviance: Second-Generation Migrant Youth, Disciplinary Return, and Transnational Social Fields of Inclusion and Exclusion return'.

assistant: **Objectives**

‘Displacing Deviance…’ is a state-of-the-art research project into transnational family practices. It examines ‘disciplinary return’ - young second-generation migrants sent ‘home’ to their countries of heritage by their parents as a disciplinary measure – a widespread practice which has not yet been the focus of direct research. Second-generation ties to the homeland are critical to issues of integration, yet understanding of second-generation transnationalism is thin. Examining ‘disiplinary return’ within the Nigerian diaspora will establish new, in-depth understanding of how migrants navigate transnational structures of opportunity and constraint through their family practice. This will shed light on the relationship between socio-economic challenges faced in ‘host’ countries, and how migrants build loyalties and identities in a transnational context. It will produce findings of relevance to policy concerns about societal challenges around multicultural integration and minority youth in the education and criminal justice sectors. The research approach is innovative, answering calls for youth-centric, multi-sited, and intergenerational research into transnational families, thus far mostly studied via first-generation migrant parents in single locations. Qualitative research with migrant parents and youth, and participatory research with migrant youth, will be undertaken in the USA, Nigeria and the UK. Supervision by a world expert, Dr Coe at Rutgers, in the outgoing phase will provide a unique training opportunity for the researcher and excellent means to build networks. Expertise gained will be transferred back into Europe in the incoming phase by working with Dr Dwyer, co-director of the Migration Research Unit (Geography Department) at UCL, a hub for migration resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Energy Efficient E-band transceiver for backhaul of the future networks' in the context of a Seventh Framework call.

assistant: **Objectives**

Network operators are looking for cost effective solutions to manage and upgrade their networks to meet the user experience demanded by European citizens. The backhauling infrastructure is becoming a bottleneck.E3Network will design an E-band transceiver for the backhaul infrastructure of the future networks. It will work in the E-band, which enables highly focused pencil beam" transmissions and huge bandwidth. The pencil-beam property facilitates a high degree of frequency reuse in the deployment of backhaul links and reduces EMF exposure of European citizens. The transceiver will use modern digital multi-level modulations to achieve high spectral efficiency. This together with the huge bandwidth will enable high capacities above 10 Gbps.The RF analogue front-end of the transceiver will be a highly integrated circuit using advanced SiGe BiCMOS technology, which enables energy and cost effectiveness. However, a consequence of transistors length reduction is an exponential increase of process variations, leading to over-constrained designs to guarantee sufficient post-fabrication performance yield. In order to achieve the required performance, a mixed analogue-digital design approach together with novel signal processing methods will be applied.Research will be driven by the end-user and industrial partners to ensure that it address the needs of the future generations of the mobile network infrastructure. The potential for an increased economic and energy efficiency of access/transport infrastructures will be illustrated by a prototype integrated in the network providing communication over 1 km with availability of 99.995%. The developed backhaul technology will strengthen the position of European Industry in the field of network infrastructure technology. It will facili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Prediction and prevention of late effects in AYA cancer survivors – An effort to understand, predict and prevent late effects in AYAs 15-39 years of age, with a focus on fertility and gonadal toxicity' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

PredictAYA is a multidisciplinary effort to fully address and improve the understanding of late effects in AYAs 15-39 years treated for cancer, by building on data from existing populations-based registers, large genomic biobanks and newly established clinical AYA cohorts. Importantly, the patient perspective will be captured in our clinical cohorts and patients’ care preferences and needs including the psychosocial impact of cancer treatment on reproductive health, sexuality and quality of life in AYAs. By cooperation between clinicians, researchers, psychologists, oncology nurses and with patient involvement, the study will use a participatory research approach and develop in co-creation with representative AYAs with cancer. This action is part of the Cancer Mission cluster of projects on “Quality of life (AYA). Our long-term goal is to develop a panel of validated biomarkers to identify individuals at high-risk of organ toxicities, aiming at clinical implementation and future individualized screening and counselling. Our main focus is on reproductive toxicity and through innovative precision medicine and pharmacogenetics, we will identify genetic biomarkers explanatory for interindividual variation in treatment induced toxicity among AYAs. A model on constitutional genetic risk for reproductive organ toxicity will be evaluated in clinical cohorts across Europe. Future precision-medicine applications and clinical implementation are envisaged as potential benefit of our proposal. Additional research questions include the prevalence, severity and timing of gonadal toxicity for different cancer treatments in both sexes, the timing and risks of pregnancy, the risk of accelerated aging, the health of the children born to AYAs. The safety and efficacy of fertility preservat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Effect size and power for neuroimaging.' (2014-2020) under Horizon 2020.

assistant: **Objectives**

There is an increasing concern about statistical power in neuroscience research. Critically, an underpowered study has poor predictive power. Findings from a low-power study are unlikely to be reproducible, and thus a power analysis is a critical component of any paper. This project aims to promote and facilitate the use of power analyses.A key component of a power analysis is the specification of an effect size. However, in neuroimaging, there is no standardised way to communicate effect sizes, which makes the choice of an appropriate effect size a formidable task. The best way today to perform a power analysis is by collecting a pilot data set, a very expensive practice. To eliminate the need for pilot data, we will develop a standardised measure of effect size taking into account the spatial variance and the uncertainty of the measurements. Communicating effect sizes in new publications will facilitate the use of power analyses.To further alleviate the need for pilot data, we will provide a library of effect sizes for different tasks and contrasts, using open data projects in neuroimaging. We will integrate our effect size estimator in open repositories NeuroVault and OpenfMRI. Consequently, these effect sizes can then serve as a proxy for a pilot study, and as such, a huge cost in the design of an experiment is eliminated.A new experiment will not be identical to the open data and as such the hypothesised parameters might not be fully accurate. To address this issue, we present a flexible framework to analyse data mid-way without harming the control of the type I error rate. Such a procedure will allow re-evaluating halfway an experiment whether it is useful to continue a study, and how many more subjects are needed for statistically sound inferences.To make our met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mobile monitoring and automatic fall detection device for elderly people living alone' (HEBE), addressing dissemination and exploitation.

assistant: **Impact**

The global ageing population is growing inexorably and in few years half of the adult population will be over 50. These trends are more significant in developed countries such as EU countries. These trends have several implications: there will be more older people in absolute as well as relative terms, there will be considerably more older old" people, there will be fewer family carers and there will be a smaller productive workforce to contribute to the financing of health and social services. Concerning this scenario, this project tends to develop an outdoor remote activity monitoring and automatic alert system based on the use of accelerometers to evaluate users mobility and to detect users falls. Falling is one of the most common problems for elderly people, especially those living alone. Actually 30% of the older persons fall at least once a year. There are different alert systems in the market but most of them respond to a users input when pressing a button. The system presented in this project will alert automatically even if the user is not able to move because of injuries suffered during fall, indicating the localisation of the fall by using GSM and GPS technology. Consequences of late assistance are dangerous: hypothermia, dehydration, infections... that in occasions can derive in death. Adding to this, the system will be able to distinguish between static and dynamic movements and send periodically data of users activity via GSM. This information will be analysed by carers determining users well being. Mobility is a subjective quality that indicates users vitality, and well being. The relevance of the project for the SMEs is high since the demand of remote care devices for elderly people is growing exponentially. The lack of reliable solutions in the market b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Foresight Security Scenarios: Mapping Research to a Comprehensive Approach to Exogenous EU Roles'.

assistant: **Innovation**

FOCUS will allow designing European security research to effectively cope with future EU roles responding to tomorrow’s challenges resulting from the globalization of risks, threats and vulnerabilities. It will do so through the elaboration of multiple scenarios based on IT-supported foresight in the form of alternative futures that are plausibility-probed and not just threat scenarios. FOCUS will design and apply an “embedded scenario” integrating method, delineating options for future tracks and broadened concepts of security research within context scenarios for EU roles to respond to transversal challenges (whose causes are exogenous, but whose consequences will be experienced within the EU). This will be performed along five big themes: 1) different tracks of a comprehensive approach as followed by European institutions, Member States and international strategic actors, particularly including linkages between the internal and external dimension of security; 2) natural disasters and environment-related hazards, focused on comprehensive risk reduction, civil protection and reconstruction; 3) critical infrastructure and supply chain protection, centred on preventing and responding to malicious attacks on EU citizens and utilities abroad as well as to meet threats before they reach the EU or affect the supply chain; 4) the EU as a global actor based on the wider Petersberg Tasks, building on EU and member states instruments and capability processes; 5) the evolution of the EU’s internal framework and prerequisites for delivering a comprehensive approach, including Lisbon treaty provisions and relevant strategies (e.g. for engagement with other international actors) as well as ethical acceptability and public acceptance. FOCUS will deliver (a) an IT Platform with tools