RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Unraveling mechanisms of drug resistance: APOBEC3A as a genomic and post-transcriptional driver of treatment resistance in pancreatic cancer'.

assistant: **Concept**

Pancreatic cancer is predicted to become the third leading cause of cancer-related death in Europe. Drug resistance to even the most effective anti-cancer-targeted therapies constitutes a major contributor to poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Kirsten rat sarcoma virus (KRAS) mutations are found in >90% of PDAC, being an important oncogenic driver. Although KRAS-targeted therapies have the potential to transform the clinical management of PDAC drastically, only a subset of patients respond, and resistance is frequent. The extent to which genomic and post-translational processes drive drug resistance remains largely unknown. Genomic analyses have identified the APOBEC family as a key driver of mutagenesis in cancer, including PDAC. Among family members, APOBEC3A (A3A) is involved in genomic alteration and post-transcriptional RNA editing, both mechanisms causative for intra-tumoral heterogeneity (ITH) and drug resistance. My preliminary data reveal that A3A induces chromosomal instability and likely ITH. In addition, I found that A3A-mediated RNA editing is prevalent in human PDACs and a mouse model for A3A. Importantly, I observed that A3A expression increases during KrasG12D targeted therapy, reduces sensitivity, and facilitates clonal outgrowth, and thus, is likely to drive drug resistance in PDAC. The ADRIP study will utilize murine and human models for A3A, to unravel for the first time whether A3A plays a dominant role in increasing ITH in PDAC (Aim1). Second, it will elucidate whether A3A-mediated genomic or post-translational modifications (Aim2) drive pre-existing and acquired KRAS inhibitor resistance. Applying a multi-omics approach, the ADRIP study aims to identify novel regulators of A3A that could serve as therapeutic targets (Aim3).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'In-time TReatment of acUte ischaemic STroke'.

assistant: **Objectives**

The problem: Today the complex and time-critical therapeutic decision in Acute Ischaemic Stroke (AIS) relies on the availability of expert stroke radiologists. However, only 5% of hospitals have facilities meeting the standards of comprehensive stroke centres. Thus, for 95% of hospitals, optimal treatment cannot be quickly identified and safely commenced. Consequently, only about 30% of AIS patients receive specialized stroke unit care across Europe. The solution: iTrust is a clinical decision support (CDS) software that uses Convolutional Neural Networks to predict the outcome of treatment strategies in AIS, based on the patient’s biomarkers as well as clinical information, including brain scan images. The prediction shown as high-resolution images of probable brain tissue outcomes in function of each treatment available. The market: Revenue from the iTrust software will come as annual licences fees: a model clearly preferred according to the surveyed KOLs. Initially, the distribution of the software will be carried out through strategic partnerships (formal agreements already signed) with the major medical scanner (CT, MRI) vendors, which will allow us to exploit their global sale channels and large installed base. The total addresable market for iTrust is over EUR 430 million per year in OECD countries. Given the high incidence of AIS, low volume (5%) of hospitals prepared to initiate the treatment and the high importance of quickly allocating the appropriate therapeutic intervention, we estimate an accumulated turnover exceeding EUR 41 million of the iTrust solution, five years post-project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Non-Covalent Interactions in Chemistry and Biochemistry' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

INTCHEM is an interdisciplinary European Early Stage Research Training programme aimed towards understanding the complex phenomena of weak interactions between molecules via non-covalent bonding. These interactions govern the formation and structure of con densed phases of molecules (clusters, liquids, crystals), adhesion of molecules on surfaces, and determine the structure of biomacromolecules, such as proteines and DNA. Although applications cover the whole field of supramolecular chemistry, crystal engin neering and large parts of biochemistry, there is no systematic interdisciplinary training of students in traditional courses of chemistry and biochemistry. INTCHEM aims to close this gap by combining the classical" knowledge of chemistry and physics, i.e . the language of molecules, their reactions and interactions, together with the "classical" knowledge of biochemistry and molecular biology, derived from existing forms of life. The training will be based on a structured 3-year curriculum including a mul ti-week laboratory rotation, a dedicated lecture series as well as generic skills workshops. This will provide young scientists with the necessary in-depth experimental and theoretical skills in analytical chemistry to develop a comprehensive understandin g of supramolecular chemistry. Fellows will be full members of the faculty-wide Graduate School of Chemistry and Biochemistry."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Territories as Responsive and Accountable Networks of S3 through new Forms of Open and Responsible decision-Making' under Horizon 2020.

assistant: **Concept**

In TRANSFORM three European regions join forces and open up their R&I activities to co-create more responsible approaches to innovation. Lombardy in Italy, Brussels in Belgium and Catalonia in Spain are all leaders in experimenting new pathways for territorial development. TRANSFORM brings them together to design, test and disseminate three sound co-creation methodological frameworks (participatory research agenda setting; design for social innovation; and citizen science). These frameworks will be at the forefront of implementation of Smart Specialisation Strategy (S3). They provide approaches and application areas of responsible and accountable territorial development through new forms of local decision-making. They have also proven beneficial in aligning science, innovation and society, making R&D more responsive to citizens’ needs, concerns and aspirations. The three initiatives will implement a mutual learning process within and beyond Europe, pairing with a parallel co-design exercise in Boston (Massachusetts, US). The work in these three clusters will support and increase co-creation and participatory processes within their R&I ecosystems, both building on existing regional commitments towards transformative opportunities and strengthen the opening effect on the organisations involved. Regional governments involved in TRANSFORM will reflect on, experiment with, learn from and adopt RRI approaches to their R&I policies and actions. Concrete examples of inclusive and sustainable territorial development will be attained, thus providing a set of reliable Policy Recommendations to transforming regional R&I ecosystems towards RRI. TRANSFORM will also be integrated into Strategic Roadmaps for the implementation of RRI within S3, addressed to S3 key players, for maximum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '‘Challenging Time(s)’ – A New Approach to Written Sources for Ancient Egyptian Chronology' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The chronology of ancient Egypt is a golden thread for the memory of early civilisation. It is not only the scaffolding of four millennia of Egyptian history, but also one of the pillars of the chronology of the entire ancient Near East and eastern Mediterranean. The basic division of Egyptian history into 31 dynasties was introduced by Manetho, an Egyptian historian (c. 280 BC) writing in Greek for the Ptolemaic kings. Despite the fact that this scheme was adopted by Egyptologists 200 years ago and remains in use until today, there has never been an in-depth analysis of Manetho’s kinglist and of the names in it. Until now, identifying the Greek renderings of royal names with their hieroglyphic counterparts was more or less educated guesswork. It is thus essential to introduce the principles of textual criticism, to evaluate royal names on a firm linguistic basis and to provide for the first time ever an Egyptological commentary on Manetho’s kinglist. Just like Manetho did long ago, now it is necessary to gather all inscriptional evidence on Egyptian history: dated inscriptions, biographic and prosopographic data of royalty and commoners, genuine Egyptian kinglists and annals. These data must be critically evaluated in context, their assignment to specific reigns must be reconsidered, and genealogies and sequences of officials must be reviewed. The results are not only important for Egyptian historical chronology and for our understanding of the Egyptian perception of history, but also for the interpretation of chronological data gained from archaeological excavations (material culture) and sciences (14C dates, which are interpreted on the basis of historical chronology, e.g., via ‘Bayesian modelling’). The applicant has already shown the significance of this approach i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High Energy Interactions: From Colliders to Cosmic Rays' in the context of a Seventh Framework call.

assistant: **Objectives**

The years 2007 and 2008 will mark the completion of the Pierre Auger observatory and the start of the Large Hadron Collider (LHC) at CERN, respectively. Whereas the former has been built to uncover the sources of ultra-high energy cosmic rays, the latter is designed to test the Standard Model of particle physics. In both experiments, the use of Monte Carlo (MC) models to describe hadronic  interactions is essential.  In CR experiments, the measured properties of extensive air showers can  be connected to the  properties of the primary particle only via hadronic MC models. At present, the poorly known interaction models prevent a reliable determination of the primary type and its energy. Thus, an improvement of present day CR interaction models is an important and urgent task. This improvement will become possible soon, since the LHC experiments will deliver for the first time a experimental data in the kinematical region important for CR experiments. This projects aims to use these data to test and to develop further the existing QGSJET simulation. It is planed  to include into QGSJET nonlinear interaction effects, to generalize the model to photo- nuclear interactions, and to account for higher twist QCD effects. Apart from its importance for a  reliable extrapolation towards the very high CR energies, such a development will have an  interdisciplinary aspect, opening the way for numerous applications in the collider physics.  A self-consistent model like QGSJET that allows one to calculate within the same scheme total and diffractive cross sections, and to treat various hadronic final states, can be applied in collider experiments both for the general studies of hadronic interactions, and for more  dedicated as, e.g., diffractive jet production. Thus the aim is to dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Topological and Measurable Shadowing Properties in Dynamical Systems'.

assistant: **Concept**

In the realm of dynamical systems, the study of the Shadowing property has emerged as a pivotal endeavor, offering profound insights into the behavior of chaotic systems. This project delves into the intricacies of the Shadowing property across three distinct frameworks: Shadowable Measures and Points, CW-hyperbolic Homeomorphisms, and Singular Flows, each with their unique characteristics and challenges. With a focus on these disparate contexts, our investigation aims to unravel the implications of shadowing for the chaotic nature of such systems, while also unraveling the obstructions that arise in continuous time cases.Our exploration into Shadowable Measures and Points harnesses we seeks  the existence of invariant shadowable measures and their role in the existence of odometers, shedding light on the fundamental nature of periodicity in chaotic dynamics. In the domain of CW-hyperbolic Homeomorphisms, we navigate the dynamic interplay of hyperbolicity and chaos. Our focus extends to investigating periodic shadowing, periodic specification, measures of maximal entropy, and the discovery of new examples that contribute to the broader landscape of chaotic systems theory. Furthermore, our investigation extends to Singular Flows, where we confront the nuanced challenges presented by singularities in continuous time dynamics. We investigate when the  existence of attached singularities forbids a flow to  satisfy the shadowing property. This exploration not only advances our understanding of continuous-time systems but also evidences a remarkable difference between the discrete-time and continuous-time contexts.


**Keywords:** Dynamical System, Shadowing Property, Entropy, Invariant Measure, Attractor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Re-inventory-ing Heritage: Exploring the potential of public participation GIS  to capture heritage values and dissonance' under Horizon 2020.

assistant: **Concept**

This research critically addresses the challenges pertaining to the management of cultural heritage in contested cross-border contexts in Europe. The cultural landscape of Derry~Londonderry, located in the North West of Ireland, provides the lens through which expressions of heritage values and dissonance, participatory practices in cultural heritage management, and the application of Geographical Information Systems (GIS) to mapping heritage a cross-border basis, are explored. The interdisciplinary research will result in the first cross-border ‘cultural heritage atlas’ on the island of Ireland, and the development of a public participation GIS (PPGIS) methodology and tool aimed at capturing the plurality of heritage values ascribed by diverse communities at multiple spatial scales. The knowledge generated will be embedded within local cultural heritage management and spatial planning networks and will also inform policies and practices. The proposed training-through-research will significantly enhance my skills and competencies as an experienced researcher, advancing previous cutting-edge work on heritage values and cross-border spatial planning, and equipping me with a range of new research methods, particularly ICT- and public participation-related, that are central to future innovation in cultural heritage management in Europe. Maynooth University, given the quality of the supervisory arrangements and the location of several research resources actively engaged in cross-border cooperation, provides an optimal setting for this research and for progressing to the next stage of my research career.


**Keywords:** Heritage values, cultural landscapes, dissonance, cross-border, PPGIS, spatial planning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EU SPACE AWARENESS' (EUSPACE-AWE), addressing dissemination and exploitation.

assistant: **Impact**

EUSPACE-AWE uses the excitement of space to attract young people to science and technology and stimulate European and global citizenship. Our main goal is to increase the number of young people that choose space-related careers.We shall target diverse groups that influence career decisions, showing teenagers the opportunities offered by space science and engineering and inspiring primary-school children when their curiosity is high, their value systems are being formed and seeds of future aspirations are sown. Activities will 1. Acquaint young people with topical cutting-edge research and “role-model” engineers, 2. Demonstrate to teachers the power of space as a motivational tool and the opportunities of space careers, 3. Provide a repository of innovative peer-reviewed educational resources, including toolkits highlighting seductive aspects of Galileo and Copernicus and 4. Set up a “space career hub” and contest designed to appeal to teenagers. Attention will be paid to stimulating interest amongst girls and ethnic minorities and reaching children in underprivileged communities, where most talent is wasted. Targeting policy makers via high-impact events will help ensure sustainability and demonstrate the social value of the space programme. We maximise cost effectiveness by 1 “Piggy backing” on existing ESERO and other teacher training courses and 2. Exploiting and expanding infrastructures of proven FP7-Space projects, EU Universe Awareness for young children and Odysseus for teenagers. EUSPACE-AWE will complement existing space-education programs and coordinate closely with ESA. We shall reach European teachers, schools and national curricula through host organisations of ESEROs and the extensive networks of European Schoolnet, Scientix and UNAWE. Designated nodes wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Prediction of future episodes of depression in primary medical care : development of a risk factor profile'.

assistant: **Objectives**

Depression is a major public health problem in Europe. There is currently no method of predicting onset and maintenance of depression.We aim to1) develop and validate a multi-factor European risk score, with an estimated specificity and sensitivity of 70%, for use by GPs to predict the onset and maintenance of depression and;2) explore the risk for the onset and maintenance of episodes of depression among primary care attenders in seven European countries.895 consecutive attenders aged 18-75 will be recruited from urban and rural general practices in each country. Information on any current depression as well as a number of likely risk factors for depression will be collected at baseline and 6 and 12 months later. A multi-factor risk score, analogous to those used in the prediction of cardiac events, will be developed to assess principal risk factors for future onset and duration of depression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a lead acid power source for hybrid electric vehicles' (BILAPS) under Fifth Framework.

assistant: **Objectives**

To reach future objectives on energy consumption and emissions attention recently shifted towards hybrid electric vehicles (HEV). Specific power needs for HEVs are more demanding than battery electric vehicles: a power-to-energy-ratio of 20-30 instead of 1 for BEVs. No low cost batteries are now available meeting this demands. Also there is a strong need for more electric power in vehicles: shifting from 12V to 36V, best served with a high specific power battery. Hence the main objective of this project is to develop a compact bi-polar lead acid battery for HEVs and Starter-Alternator applications, with a specific power of 600W/kg.Further objectives are a weight reduction of 75% compared to conventional lead acid, a maximum (dis) charging time of 30 seconds during peak power, a life time of 5 years, an operation temperature of -15 to +40 degrees Celsius and a maximum price of 1500 Euro.