RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Deciphering the mechanism of irreversible replication fork arrest' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

DNA replication is essential for cell proliferation. Obstacles to replication generate replication stress by stalling replication forks. In response to replication stress, cells activate the DNA damage checkpoint pathway that coordinates a cellular response to prevent DNA damage and ensure cell survival. One essential function of the checkpoint is to stabilise stalled replication forks and ensure that replication will resume after obstacles are removed. Specifically, the yeast checkpoint effector kinase Rad53 and its human counterpart Chk1 are essential to prevent irreversible replication fork arrest (IRFA), DNA damage and cell death under replication stress. A screen to identify factors required to promote IRFA has revealed a role for unrestricted recombination events in promoting IRFA. However, mechanistic studies are still required to understand how the checkpoint stabilises stalled forks and prevents IRFA. Recently, in vitro replication reconstitution with yeast purified proteins in the lab has helped uncover important mechanisms of DNA replication. I will use this system to reconstitute IRFA in vitro and determine the proteins and enzymatic activities required to promote IRFA in the absence of the checkpoint. I will then look for phosphorylation targets of Rad53 to understand how the checkpoint prevents IRFA. I will study changes at the DNA and replisome of stalled replication forks by 2D electrophoresis, mass spectrometry and cryo-EM to understand the causes of the irreversibility of IRFA. We seek to better characterise an essential function of the DNA damage checkpoint and define a new role for unrestricted recombination in promoting DNA damage. Main challenges of current cancer therapies include the appearance of surviving checkpoint-deficient cancer cells. Desp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Crystallographic study of the human receptor-like protein tyrosine phosphatase u'.

assistant: **Concept**

The phosphorylation of tyrosine residues is an essential element of many signal transduction pathways triggered by hormones, mitogens, and oncogenes that lead to processes such as cell growth, proliferation, and differentiation. Protein phosphorylation is reversible and controlled by the opposing action of protein kinases and phosphatases that catalyze phosphorylation and dephosphorylation, respectively. In our work, we will investigate the crystal structure of a representative member of the receptor-like protein tyrosine phosphatase, namely, human PTPu, using X-ray diffraction techniques. This is particular interisting in light of the observation that the extracellular portion of PTPu, which is reminiscent of the extracellular portion of neural cell adhesion molecules (N-CAMs), participates in forming homophilic binding interactions. It is possible that signals resulting from cell-cell contacts may be transduced across the plasma membrane resulting in modulation of the catalytic activity of PTPu. It is of interest to understand the structure of PTPu which would provide insight into the structural mechanism of transmembrane signal transduction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Games in Logic: Reaching Out To Classical Game Theory'.

assistant: **Innovation**

Logic in Games" is an important area of research using the concept of procedural activities with interdependency in mathematical logic (model theory and proof theory), foundations of mathematics (set theory), computer science (automata theory, computation al complexity theory), computational linguistics (formal semantics and pragmasemantics) and philosophy (theory of rationality). Despite the importance and width of scope of "Logic in Games", it is but a small part of research on games: The methodology and the language of games are central to many social conventions and formalizations of social phenomena. The scope of games stretches to include economics, social sciences, and psychology. Traditionally, the interaction between "Logic and Games" and this wider scope of game theory has been very limited which we see as a lamentable deficiency. The aim of the fellowship GLoRiClass is to educate young researchers who are knowledgeable in all parts of the "Logic and Games" community, apply techniques from the wider scope of game theory and reach out to those researchers not in logic. This demanding goal presupposes a spirit of interdisciplinarity. It will be reached by 1.broadly educating the early stage researchers in all relevant research areas from "Logic in Gam es", 2.tackling research problems in "Logic and Games" that are motivated by the wealth of game-related literature that exists outside of the logic community. The convergence of different ideas and techniques in "Logic and Games", as well as the currentl y developing contacts with researchers from economical game theory yield a unique and urgent opportunity to develop a new kind of future researcher in logical game theory. The track record of the organizers of GLoRiClass in terms of internationality, inter discipli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European step centres network' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The strategic objective of ESCN is establish and execute a STEP/Product Data Technology (PDT) training and technology transfer programme, a necessary building block to make STEP a sustainable competitive advantage for European industry. ESCN will establish and execute a STEP training program targeted at industrial and research project teams.STEP is in theory accessible to all since it is an international standard. However it is a lengthy process for newcomers to familiarise themselves with it due to its complexity, its broad scope and continuous development. ESCN will target EU funded projects using STEP technology, particularly SMEs, who have an increasing need for PDT and standardised interfaces, but have found it difficult to acquire this emerging technology. The aim of ESCN is, - To train teams of professionals from European projects and SMEs in the use and further development of STEP/PDT; - To execute dissemination and awareness activities in order to promote the implementation of STEP/PDT in an industrial context; - To increase the participation of European STEP Centres in the development and industrial deployment of STEP/PDT as consultants. The scope of the training and technology transfer activities encompasses further, - Product data technology in general and STEP in specific in order to assist European projects and SMEs in using modellers, EXPRESS, and STEP Application Protocols; - The collective areas of expertise and industrial coverage of the ESCN centres e.g. automotive, process industry, ship building, aerospace.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantifying Freedom: Data production and everyday life in the Liberated African village, 1807-1901' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Quantifying Freedom: Data production and everyday life in the Liberated African village, 1807-1901, is a historical ethnography of Liberated African villages in colonial Sierra Leone and the Gambia under British rule. Upon being returned to the coast, many Liberated Africans were settled in English-styled villages managed by the Church Missionary (CMS) and Methodist Missionary Societies (MMS), with oversight from the colonial Liberated African Department. These villages initially formed the basis of an abolitionist social experiment: to attempt to prove the relative productivity of free black labor over slave labor, the civilizational capacities of Africans and alternatives to the slave trade. To this end, these villages were simultaneously sites of data creation and extraction in which clergy village ‘managers’ collected data on everything from church attendance to livestock numbers. After an initial wave of British and German missionary managers, Liberated Africans took over these positions and innovated their own data collection processes that responded to their questions and concerns. This project proposes to study data-driven social reform, race, and the expansion of the British Empire in West Africa in the aftermath of the abolition of the Atlantic slave trade. The objective is to both understand and formulate an account for the impact of the quantification in the Liberated African village on ideas of race within the British Empire, on histories and techniques of British data collection and strategies of  colonial governance and social reform in West Africa and Britain. The objectives in terms of training and career advancement is to improve the researchers capacity to produce high-impact publications, to acquire more experience in collaborating with others in tea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Bridging atomistic to continuum - multi-scale investigation of self-assembling magnetic dots during Epitaxil growth'.

assistant: **Concept**

Spontaneous formation of nanostructures through kinetic and thermodynamic morphological instabilities at solid surfaces is increasingly recognized as an attractive, low-cost alternative to top-down schemes for nanopatterning. We propose an integrated app roach to examine the self-assembly of magnetic nano dots by spanning the atomistic to the continuum scales. The work will involve ab initio calculations, as well as statistical mechanics, mesoscopic and continuum calculations of the evolution of nanostructural morphology, composition, and self-assembly during deposition and annealing. By parameter passing, each effort will feed into the other, as the information at the smaller scales will be employed at the larger scales scale calculations, enabling us to b ridge a wide range of length and time scales.The ultimate goal of the project is to develop an understanding of the important materials issue governing nanoscale self-assembly, and to develop models that enable the first-principle design of novel super-high density magnetic storage materials. The understanding of the fundamental phenomena accompanying dot formation gained through computational approaches and experimental validation will facilitate the development of processing methods that yield regular arrays of magnetic nano dots for the next generation of magnetic storage materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Coherent control and molecular dynamics in the era of terahertz' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Intense electromagnetic fields in the Terahertz (THz, 10^-12 Hz) frequency range have recently become tabletop available. In this proposal I offer to advance this unique range of frequencies into the world of gas phase coherent control and molecular dynamics. THz fields interact with molecules via their permanent electric dipoles, and induce molecular orientation, thus providing a new molecular handle (in addition to the commonly used visible/near-IR optical frequencies), for inducing and studying the rotational and molecular dynamics in the gas phase. I will utilize both THz and optical fields as two distinct molecular handles to induce unique molecular rotational responses that are inaccessible otherwise, and are invaluable for various spectroscopic techniques in the realm of molecular dynamics (such as high harmonic generation, molecular frame Photo-electron and Photo-ion angular distributions and ultrafast X-ray diffraction). THz induced inversion-asymmetry (orientation) enables nonlinear optical interrogation techniques that are forbidden in isotropic gas samples (such as second harmonic generation). Combining the polarizability-selective and dipole-selective interactions of optical and THz fields respectively, will enable far improved control of 3D molecular angular distributions – a long standing goal in chemistry and physics. The efficient THz-dipole interaction require field intensities that are orders of magnitude lower than those required by optical fields, and will be implemented for studying fragile samples such as bio-molecules. The dipole-selectivity of the THz field will be used for probing dynamic processes involving changes in the molecular dipole (such as trans<-->cis isomerization in azobenzene). The broadband resonant interaction of THz with the mul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Film Festivals and War: A Fe-Male Perspective (1939–present)' in the context of a Horizon Europe call.

assistant: **Objectives**

A transdisciplinary project traversing cultural history, film and film festival studies, gender studies and digital humanities, FESTWAR FM will offer the first sustainable analysis of film festivals (FF) and war from a gender perspective. Despite numerous examples of women’s involvement in wartime FFs, no global study has yet analysed their roles in FFs in the context of ongoing wars, nor theorised what we might learn from it. The project will break new ground by investigating FF’s evolution as places of memory in conflict situations with a specific focus on women’s position within this process. This will be done through three case studies connected to three armed conflicts that have occurred in Europe since the creation of the world's first FF in Venice in 1932: WWII (1939-1945), Yugoslavia (1991-1999), and Ukraine (2014-present). The research will compare global responses to these wars through analysis of the world’s five most prestigious ‘A-list’ FFs (Venice, Cannes, Berlin, Toronto, Sundance), with the European and local response of the major FFs operating in the war affected Yugoslavia (Pula, Belgrade, Sarajevo) and Ukraine (Kyiv, Odesa). The analysis will be organized around three categories (CAT):  CAT1 – (wo)men on the screen and behind the cameras; CAT2 – (wo)men in decision-making structures; CAT3 – (wo)men on the stage and the red carpet. The project will produce a monograph, two academic articles and an online digital archive (ODA) including a) a data visualisation chart, b) a selection of film extracts, photographs and archival materials illustrating each case study, and c) a podcast with interviews with women engaged in analysed FFs during wars in Yugoslavia and Ukraine. In doing so, it will introduce a gendered innovation in the field of war-related FF st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nano electro-optomechanical programmable integrated circuits', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

NEUROPIC will design, build, measure, and explore a novel programmable photonic chip architecture with transformational impact potential on photonics for data centers, autonomous vehicles, quantum information processors, and much more. We will explore and pioneer programmability of large-scale photonic circuits using nanoelectromechanical technologies, which benefit from ultralow power consumption, compact footprint, and potentially faster operation than existing approaches. Building on very recent breakthroughs from the consortium partners, the nanotechnology is now in place to begin the exploration of programmable photonic chips scaled to thousands of programmable nodes. The main objectives range from sustainable and high-performance silicon nanomachining over establishing a scalable platform for ultralow-power nanoelectromechanical programmable silicon photonics to massively parallel optical interconnects. Our final goal is to use the network of independent and fully controllable nodes for neuromorphic computing to quantify the role of complexity for artificial intelligence. The objectives present a strong mutual synergy, scientific impact, and sustainability and set the foundations for four highly attractive business cases with complementary profiles in terms of risk and market size. NEUROPIC is therefore designed to address the fundamental scientific and technological questions of today whose answers hold potential for very large commercial impact in the future. Our quest comes with a new set of challenges and calls for a radically new approach to photonics. NEUROPIC unites some of the world’s leading researchers and companies in nanotechnology, photonics, advanced manufacturing, and complex systems in a risky and highly interdisciplinary research project with the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DOT1L in Osteoarthritis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The DOTOS project will study the role of DOT1L in synovial joint development,  homeostasis and disease with specific attention towards osteoarthritis (OA), one of the most common chronic diseases.We identified an association between the DOT1L (DOT1-like histone H3 methyltransferase) gene and OA. Histone methylation is a regulator of gene transcription. Some histone methylations result in increased gene expression, e.g. lysine methylation at lysine 79 in histone 3 (H3K79). DOT1L is the only known H3K79 methyltransferase. We demonstrated that DOT1L plays an important role in the canonical Wnt signaling cascade in a molecular complex involving TCF transcription factors.These observations stimulated us to now investigate the role of DOT1l in joint development and disease, processes associated with Wnt signaling.The key hypothesis for this project states that DOT1L and Wnt signalling are required for joint development and homeostasis but that their increased activation in progressive OA is detrimental to the joint.This project will teach us how DOT1L interacts with Wnts and other signalling pathways in joint biology and disease. In addition, we aim to develop a basis for future therapeutic approaches.Dr. Monteagudo, the candidate for the fellowship, will be trained in animal models and in translational research hypotheses. She will benefit from complementary skills training and interactions with industry to gain further maturity and independence as a researcher. This additional training will be beneficial to her career as well as to the European Research Area as there is a great societal need for translational researcher in the field of chronic joint diseases able to make links between basic biology and clinical questions. The project pays specific attention to cross-sectori
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EUROPEAN PLATFORM FOR EXCELLENCE IN CSR RESEARCH' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

This project aims to address the shortcomings of a fragmented and difuse European CSR research agenda. It will achieve this through a structured and dynamic programme of cooperation where academic institutions, businesses and stakeholders will have a real opportunity to influence the setting of research priorities as well as the use and exploitation of research findings. Such coordination will allow European CSR-related research to be aligned, integrated and widely disseminated, creating new synergies among existing academic centres of excellence. The objectives of the European Platform for Excellence in CSR are to: - Lay the foundations for a structured, coherent and dynamic coordination of existing and future research activities in the field of CSR at European level - Foster cooperation, participation and co-ownership in advancing CSR research in terms of dialogue and partnerships between academia, the business community, policy-makers and other stakeholders, by creating channels for these groups to provide structured input to research agendas - Create an effective system for dissemination and integration based on innovative tools, methods and processes thai will best exploit past, current and future research efforts and outcomes on CSR-related issues and which will benefit academia, businesses, policy-makers, other stakeholders and the public audience The consortium partners will build the foundations for a European Research Area in the field and a European and Global reference point for the advancement and dissemination of knowledge on CSR by strengthening and expanding collaboration between academics between disciplines, between types of research (fundamental and applied reserach), between generations, and between the academic community at large and the business an