RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Function of long non-coding RNA in Crohn Disease Ulcer Pathogenesis' (2014-2020).

assistant: **Concept**

The Inflammatory Bowel Diseases (IBD), Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic/relapsing disorders that affect over six million individuals worldwide. Mucosal ulcers, the hallmark of CD, are the result of a complex interaction between microbiota, immune cells, and gut epithelia. Healing of mucosal ulcers is associated with better outcomes, but is achieved in less than half of cases. Past attempts to suppress central and conserved nodes of the immune system failed due to opposing off-target deleterious effects on epithelial renewal. Therefore, there is a critical need to identify more tissue specific targets that lead to mucosal healing and to improved outcomes.Using mRNAseq of intestinal biopsies, we identified a widespread dysregulation of long non-coding RNAs (lncRNA) in the ileum of treatment naïve pediatric CD patients. Importently, we identified significant correlations between lncRNA and mucosal ulcers.  CD lncRNA, after carful mechanistic exploration, are highly promising targets for potential future intervention as they regulate diverse cellular functions and exhibit a more tissue specific expression in comparison to protein coding genes. The core goal of this proposal is to understand the role of CD lncRNA in ulcer pathogenesis focusing on granulocytes and epithelial functions in the contexts of their interactions with the microbiota.I plan to utilize state of the art informatics, RNAseq and microbiome profiles together with advanced and novel experimental lab model and co-culture systems, patients-derived prospectively collected tissues, and gut microbiota to explore the role of CD lncRNA function in mediating healing of mucosal ulcers. This work carries the potential to guide new novel therapeutic strategies for mucosal healing with minim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Optical Near-field Electron Microscopy' (ONEM), addressing dissemination and exploitation.

assistant: **Impact**

The project will establish a new hybrid imaging technique, Optical Near-field Electron Microscopy (ONEM), that harnesses the best of two worlds: firstly, the non-invasiveness of probing a sample with light, and secondly, the high spatial and temporal resolution offered by electron optical read-out.Interactions and dynamics at interfaces are crucial throughout science and technology, be it in material science, in battery research, or in membrane biology. Imaging these interactions with nanometre spatial resolution and millisecond time resolution, without labelling, without damaging the specimen, and without limitations in observation time is a huge challenge.ONEM is based on the photoelectric effect: visible light illuminates a sample within a liquid cell, and the resulting near-field interference pattern is converted into an electron flux within a nearby photocathode. The spatial variations in electron flux are imaged using aberration corrected electron optics within a low energy electron microscope. We will build the first ONEM prototype, and use it for studies on electro-plating, and on protein oligomerization in in artificial lipid membranes.These experiments will show that ONEM enables label- and damage-free imaging at 3 nm resolution and high frame rates (up to kHz), over extended periods. They will open the door to investigations of a wide range of electrochemical phenomena (corrosion, mass transport in batteries, liquid crystal switching), and to studies of membrane biology (pore formation, oligomerization, protein diffusion,...), that are out of reach for current imaging technology.The project will be conducted in close collaboration with user facilities and industry partners, in order to facilitate rapid commercialization of this disruptive new technology.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PROMoting youth Involvement and Social Engagement: Opportunities and challenges for 'conflicted'  young people across Europe' to be submitted under Horizon 2020.

assistant: **Abstract**

The challenges faced by young people across Europe have been the focus of public, political and academic debates at local, national and international levels. Young people face tough choices in key areas of social life that affect their participation in society, and their potential marginalisation from it: from structural issues of unemployment, lack of access to affordable housing and debt problems, to information overload on big questions like the environment, identity, faith and radicalisation, and negotiating the moral challenges of illegal markets and an increasingly sexualised social-media generation. While there are wide variations in opportunities and challenges between and within countries, young people today face tough choices in negotiating this moral maze. The PROMISE project will investigate how young people’s, often negative, responses to these problems create conflict, and how, instead, their responses can provide opportunities for positive social engagement. By addressing the experiences, values and attitudes of European youth seen to be in conflict with older generations, authorities and social norms PROMISE will get to the heart of barriers and opportunities for social engagement. We will employ a four pronged methodology to gather and analyse data (primary and secondary) on a cross-national level, alongside comparative ethnographic case study data that uniquely addresses the experiences of ‘conflicted’ youth within the context and social history of each country. Each case study will address a site of conflict and stigmatisation as a (potential) site of innovation or social change. Throughout the process, we will involve young people across Europe in setting the agenda, in documenting their situation and in articulating their needs. PROMISE will produce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Utilisation of the mesenchymal stem cell receptome for rational development of uniform, serum-free culture conditions and tools for cell characterization'.

assistant: **Innovation**

Stem cells offer a promising avenue to therapy for a wide range of complaints. However, for this potential to be realized, a consistent and plentiful supply of well-characterised stem cells is essential.  There has been relatively little progress in the development of new culture technologies for the large-scale manufacture of mesenchymal stem cells (MSCs). There is a strong possibility that this limited ability to produce stem cells will result in delays to the translation of new therapies to the clinic. This will have a direct negative effect on the health of European citizens suffering from diseases untreatable by conventional medical technology and delay European efforts to promote “NanoMedicine - Nanotechnology for Health”.  PurStem will progress the state of the art in the production of mesenchymal stem cells (MSCs) in large quantities. The current state of the art has several weaknesses - there are no standards for characterisation, isolation or identification of MSCs from any tissue, nor are there standard protocols for differentiation of MSCs to various lineages.  Additionally, surface markers used for MSC characterization lack specificity and cryopreservation protocols are not standardized.  Critically, current production methods for MSC require the use of animal products with major contaminant implications.         PurStem will • Identify the MSC “receptome” and  • Use this repertoire of growth factor receptors to  • Develop novel serum-free media for MSC production. PurStem will also result in novel antibody reagents for specific MSC characterization and contribute to GMP manufacturing standards to enable rapid progression to production of serum-free MSC for clinical applications. The impact on a range of therapeutic and research domains of having a reliable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Metrological Evaluation and Testing of Robots in International CompetitionS' (METRICS).

assistant: **Concept**

The METRICS project will organise challenge-led robotics competitions inThe METRICS project will organise challenge-led robotics competitions in the four Priority Areas (PAs) identified in the topic ICT-09-2019-2020: Healthcare, Inspection and Maintenance, Agri-Food, and Agile Production. METRICS is designed to organise competitions as reproducible and objective evaluation campaigns and aims to structure in a sustainable way the European robotics and Artificial Intelligence (AI) community around the four PAs. In order to assess the reliability of the different competing robots in a rigorous and unbiased way, METRICS will develop an evaluation framework based on metrological principles. For each competition, METRICS will organize 3 field evaluation campaigns (in physical environments) and 3 cascade evaluation campaigns (on datasets) to engage with the AI community. The competitions are designed to draw attention from the entire economic sector, the academia and Digital Innovation Hubs (DIH) in Europe, while stimulating public engagement. Indeed, METRICS will implement a dedicated strategy to mobilize external partners and sponsors to support the organization of the competitions or ensure their industrial relevance. A specific outreach strategy will be developed to promote robotics systems towards the general public and ensure the compliance of robots with ethical and socio-economic principles. METRICS brings together 17 partners, all expert in robotics competition and metrology, with highly complementary testing facilities and networks in the four PAs. This experienced consortium will ensure that METRICS benefits from the feedback of past and current competitions and projects and is highly complementary with European initiatives and networks (e.g. DIH). Thus, METRICS wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Discovery of new herbicides through an exploration of the chemistry and biology of the naturally occurring phyllostictines' to be submitted under Horizon 2020.

assistant: **Abstract**

Phyllostictine A (PA) is the most potent member of a new class of natural product isolated from the fungus phyllosticta cirsii that displays strong herbicidal activity and is an exciting new lead in crop protection. Martin Riemer (PhD 2014, University of Potsdam, Germany) will undertake the first chemical synthesis of phyllostictine A (PA) at the University of Warwick, UK and participate in a multi-disciplinary project that spans the interface between chemistry and biology. PA constitutes a formidable synthetic challenge and its synthesis will require him to develop a variety of new chemical reactions and processes. Emphasis will be placed on sustainable, catalytic transformations and on adhering to the principles of the ‘ideal’ synthesis (e.g. atom, step and redox economy), work which builds directly on the applicant’s skills and expertise. Through a secondment to Rothamsted Research, Riemer will broaden his knowledge base by testing a selection of synthetic analogues against invasive weeds. Taken together, these activities will advance our understanding of the mode of action of PA, and pave the way for the development of simplified analogues for use in agriculture. Moreover, through the planned training and mentoring activities, Riemer will develop into an outstanding early career researcher of great potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel technology for biobutanol production' (BUTANOVA) targeting Horizon 2020.

assistant: **Abstract**

Butanol is a 4-carbon alcohol generally used as an industrial solvent with a growing multi-billion market and with a high potential as a renewable fuel. It is commonly produced from fossil fuels through very pollutant processes, strongly contributing to GHG emissions, and thus requiring more sustainable and greener production alternatives. During the past decade, some of the limitations in the biological production of butanol were tackled with the development of solventogenic microorganisms and advances in fermentation approaches. However, none of these solutions has reached industrial production and are either focusing on the less interesting isobutanol or based on anaerobic processes and still limited by to the use of Acetyl-CoA as the pathway precursor for n-butanol biosynthesis, thus limiting the process yield and productivities and the diversity of hosts that can be used and, consequently, the choice of feedstock. BUTANOVA technology is a novel biological alternative for the production of n-butanol based on an innovative and proprietary metabolic pathway developed by SILICO.  BUTANOVA comprises a more efficient metabolic pathway, capable of higher yields, productivities and purity in either anaerobic or aerobic operation, for the production of n-butanol from a new precursor, alpha-ketoglutarate. Conversely to competing solutions, the use of alpha-ketoglutarate opens the door to a great variety of hosts and feedstock use. The major objective of BUTANOVA is the technology demonstration and market introduction of a cost-competitive alternative for the biological production of n-butanol, including the scaling-up and process documentation as part of Phase 2.To meet this end, it is required to first complete an IP risk analysis and technological/market feasibility evalua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Customizable AI-based in-line process monitoring platform for achieving zero-defect manufacturing in the PV industry' (Platform-ZERO), addressing dissemination and exploitation.

assistant: **Impact**

Third generation photovoltaic (PV) technologies offer high performance and customizability for ubiquitous integration (BIPV, VIPV, agrivoltaics, IoT...), and are well suited to Industry 4.0 manufacturing. However, their high-complexity and finely-tuned production processes make them prone to the appearance of critical defects with just small deviations from standard process conditions leading to significant production waste. In this context, Platform-ZERO provides a new paradigm for the third generation PV industry through the development of a self-learning, modular and customizable in-line process monitoring platform that provides in-situ holistic production assessment and control employing non-destructive inspection methods and industry 4.0 Artificial intelligence (AI)-based tools to allow an early detection, correction and/or prevention of pre-critical production faults. In order to achieve this ambitious objective, the Platform-Zero consortium joins together partners with a strong background in advanced characterization of complex materials and process monitoring methodologies; and partners who are leaders at the European level in the development/production of third generation PV devices and related products providing a balanced contribution of academy and industry with a high degree of multidisciplinarity. Platform-ZERO will demonstrate its innovative holistic process monitoring technology through the development, installation and validation at TRL7 of 4 functional demonstrators in different PV and PV-related manufacturing lines: roll-to-roll (CIGS solar foil), sheet-to-sheet (high efficiency CIGS and perovskite) and line flow (smart coatings) PV and PV-related manufacturing lines. The Platform-ZERO technology will contribute in increasing the overall quality and r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Humic substances in performance assessment of nuclear waste disposal: actinide and iodine migration in the far-field' (HUPA) targeting Fifth Framework.

assistant: **Abstract**

The impact of humic substances on the lengthen safety of nuclear waste disposal is quantified. Results are tailored for implementation in PA. Natural humic colloids have been shown to migrate like ideal tracers over long distances and time-spans. It has also been unarobiguously shown that there is a large potential impact by humic colloid mediated radionuclide migration. However, due to discrepancies between the behaviour of radionuclides from laboratory studies and natural chemical analogues, presently no final conclusion is possible on this issue.This can only be resolved by development of adequate process understanding. The project takes a necessary broad approach, including development of model humic substances, generation of missing data and development of models and transport codes. The impact on PA is visualized by migration case studies. The long-term safety relevant actinide ions and iodine are studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The contribution of social capital in the social economy to local economic development in western' under Fifth Framework.

assistant: **Concept**

To carry out a three-year programme of research that identifies the extent to which social enterprises contribute to the accumulation of social capital (as networks of mutually and trust which minimise the transaction costs of information and knowledge) in the social economy, and in turn, the wider local economy in four member states. The research will identify baseline indicators and measures of social enterprise, social economy and social capital and incorporate these into new methodologies of socio-economic profiling and social auditing for use in the research in two localities in participating member states.The aim of the research is to - develop new models of local social and economic development - demonstrate ways in which knowledge generated via social capital accumulation assists in local economic development and growth, and the role of social enterprises in the social economy within that - generate new methods to integrate policy concerns of social inclusion and economic development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Analytic-probabilistic methods for borderline singular integrals'.

assistant: **Concept**

The proposal consists of an extensive research program to advance the understanding of singular integral operators of Harmonic Analysis in various situations on the borderline of the existing theory. This is to be achieved by a creative combination of techniques from Analysis and Probability. On top of the standard arsenal of modern Harmonic Analysis, the main probabilistic tools are the martingale transform inequalities of Burkholder, and random geometric constructions in the spirit of the random dyadic cubes introduced to Nonhomogeneous Analysis by Nazarov, Treil and Volberg.The problems to be addressed fall under the following subtitles, with many interconnections and overlap: (i) sharp weighted inequalities; (ii) nonhomogeneous singular integrals on metric spaces; (iii) local Tb theorems with borderline assumptions; (iv) functional calculus of rough differential operators; and (v) vector-valued singular integrals.Topic (i) is a part of Classical Analysis, where new methods have led to substantial recent progress, culminating in my solution in July 2010 of a celebrated problem on the linear dependence of the weighted operator norm on the Muckenhoupt norm of the weight. The proof should be extendible to several related questions, and the aim is to also address some outstanding open problems in the area.Topics (ii) and (v) deal with extensions of the theory of singular integrals to functions with more general domain and range spaces, allowing them to be abstract metric and Banach spaces, respectively. In case (ii), I have recently been able to relax the requirements on the space compared to the established theories, opening a new research direction here. Topics (iii) and (iv) are concerned with weakening the assumptions on singular integrals in the usual Euclidean spac