RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular mechanisms of photoprotection in plants.' to be submitted under Horizon 2020.

assistant: **Abstract**

Photosynthesis is a biological process of primary importance, as it provides the energy that drives food, feedstock and biofuel production and mitigates climate change. Light in excess of photosynthetic capacity can be damaging, thus ways to protect against damage have evolved, including ways to minimize light absorption, detoxify reactive oxygen species generated by excess light, and dissipate excess absorbed light. Together, these processes are known as photoprotection. Despite the physiological importance of photoprotection, the molecular mechanisms that protect against light stress remain largely unknown, especially those that protect from prolonged light stress. The objective of the proposed research project is to solve molecular mechanisms of photoprotection in plants. My specific aims are to 1) investigate the function of known involved factors in sustained energy dissipation in the model plant Arabidopsis, 2) identify novel molecular players and 3) use an organism that is genetically adapted to cope with high light stress, the evergreen Norway spruce. The research will be carried out in my laboratory where genetics, biochemistry, biophysics and physiological approaches will be combined to address this problem. The research in my group will provide insights into fundamental mechanisms of light energy capture, utilization and dissipation and will lead to the identification of new targets for manipulation, key to increasing yields of energy and food crops.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The genomic consequences of domestication for ruminant pathogen evolution and herd diversity across ten millennia' to be submitted under Horizon Europe.

assistant: **Abstract**

Palaeogenomics has transformed our understanding of the genetic consequences of domestication, particularly for livestock species, first brought into the anthropological sphere ~10,000 years ago in Southwest Asia. However, we know little of how domestication shaped the evolution and frequency of pathogens affecting livestock. Moreover, the evolution and occurrence of zoonoses - pathogens infecting both animals and humans - in Neolithic and later societies has been debated, but studies have focused on human remains to obtain ancient pathogen genomes, neglecting animal sources.HERDPATH will address this deficit through large-scale palaeogenomic screening of faunal remains from Eurasia across 10,000 years. Focusing on sheep and goats, two of our oldest domesticates and which share a high number of common diseases with humans, HERDPATH will analyse both pathogen and ruminant genomes to reveal the dynamic between ancestry, husbandry-induced inbreeding, immune gene variation, and pathogen occurrence through time. Bioinformatic screening will produce a temporal, multi-species archive of pathogen-positive livestock, providing the first molecular baseline of infectious disease presence in domestic herds. Time-stamped pathogen genomes will permit the timing of key evolutionary events such as host adaptation and the origin of lineages circulating today. Using data derived from multiple livestock species, HERDPATH will explore the co-evolutionary trajectory of pathogens and immune genes since domestication.Exploiting temporal genomes from underexplored sources will reveal how domestication shaped pathogen evolution towards increasing host adaptation, helping us to model the evolutionary dynamics of future livestock disease, zoonosis outbreaks, and food security. HERDPATH will be a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'UNDERSTANDING OPPORTUNISTIC SEAWEED HOLOBIONTS: HOW THE INTERACTION WITH THEIR MICROBIOME MODULATES THEIR METABOLOME?' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Global change is expected to increase the arrival of opportunistic macroalgae, as well as the rate and extent of blooming events, causing severe negative impacts on marine and coastal ecosystems. Opportunistic macroalgae may represent a particularly interesting source of secondary metabolites, as they adapt to highly variable environments and have a withstanding capacity to cope with environmental stressors. Valorization could be a key solution to transform this huge biomass of opportunistic species into a potential for biotechnological and socioeconomic innovation. Before this, it is crucial to have a full understanding on how seasons, life stage and environmental variability modify their metabolome and thus, the quality of their biomass. In this regard, the holobiont perspective (relationship of macroalgae with their microbiome) is paramount to understand comprehensively the macroalgal ecophysiology and the environmental factors modulating their metabolome, all along their life-cycle until their degradation. HOLO-CWEED aims to study opportunistic macroalgae as holobionts to: 1) shed light on the opportunistic macroalgal ecophysiology, 2) assess the intrinsic (microbiome) and extrinsic (environment) factors affecting the quality of their metabolome along their life-cycle, and 3) assess the impact of massive macroalgal strandings on the surrounding seawater. This work will require an inter-disciplinary methodological approach gathering microscopy, biochemistry, metabolomics and metabarcoding, to have a complete understanding of macroalgal holobionts. The host institution facilities and expertise will be essential for stepping from fundamental research to applied research through the valorisation of macroalgae. HOLO-CWEED provides an original scientific approach to under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Revealing second messenger functions in bacterial stress response,  cell differentiation and natural product biosynthesis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Sophisticated signalling systems enable bacteria to occupy almost every single niche on our planet. In such systems, second messengers are crucial information carriers that elicit cellular adaptation to diverse signals. Current dynamics in signalling research have led to the discovery of an exquisite collection of nucleotides that bacteria use as second messengers, including cyclic dimeric adenosine monophosphate (c-di-AMP). A unique feature of c-di-AMP is its essentiality, making it an attractive target for antibiotics.The main objective of this proposal is to uncover the full repertoire of c-di-AMP functions and metabolism in bacteria by using Streptomyces as a model. Streptomyces are our most prolific antibiotic producers and represent an excellent system to study multicellular differentiation. They live in soil, where they encounter diverse environmental cues that trigger antibiotic production and a complex transition from multicellular filaments to spores. c-di-AMP enables Streptomyces to survive osmotic stress caused by rainfall and drought, but interferes with development. How c-di-AMP affects differentiation and how these bacteria adapt to stress signalled by c-di-AMP is unknown.Here, we propose that bacteria use a novel transmembrane signalling pathway to remodel their cell wall for surviving stress mediated by c-di-AMP. We will challenge the current view in the field by showing that the set of enzymes involved in c-di-AMP dynamics is larger than it is currently believed and we will identify new c-di-AMP effectors. Finally, we will explore the potential of c-di-AMP for manipulation of natural product biosynthesis and address the function of a linear di-AMP molecule that is new to signalling research. Our proposed research will not only lead to the discovery of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of a new generation of low-voc, high performance Coatin gs based on chemical Crosslinks between binder and Wood', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Although this project did not result in a paint product, Rhodia had developed low viscosity isocyanates and low temperature deblocking isocyanates. Janssen did lots of work on UV-absorbers to be grafted onto the wood or the binder. The institutes had the opportunity to host some postgraduates and to participate in European networks as Thematic Network on Polymers and present new knowledge on the degradation mechanisms of wood on COST E18 working group 1 and 2. Sigma could use the information generated in this project for future paint developments, based on high technology and good price - performance relation. Gaulhofer had the opportunity to look into future technologies and open the way for an up-stream information exchange to supplier (Sigma) and their suppliers (Janssen and Rhodia). Outdoor weathering tests showed an increased colour stability of the experimental raw materialObjectives and content The competitive position of coated wood for outdoor use is considerably reduced by the high maintenance costs due to repainting every 3-4 years, in particular for semitransparent coatings. This has lead to an increasing competition by plastic and metal (aluminium) which means a serious treat for the market position of both manufacturers of wooden window, doors etc. and the producers of wood-coatings since plastic and metal are normally not coated. The objective of this research project is to develop a whole new generation of wood coatings based on physical adhesion with the wood. Therefore the wood-coating interface is very sensitive to degradation by UV-light and moisture which can be prevented by providing a chemical cross-linking between both materials. That such a technology is now considered feasible is due to recent findings in the field of through and through chemic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Table-top cathodoluminescence microscope' in the context of a Horizon 2020 call.

assistant: **Objectives**

We propose to develop a turnkey table-top cathodoluminescence (CL) microscope demonstrator that combines electron microscopy and optical spectroscopy to make optical images with a spatial resolution as small as 20 nm. The instrument design builds on expertise on CL microscopy that I have built up during my ERC Advanced research that has led to a highly successful and highly rewarded CL research program. The new microscope design is fully user-friendly, has a footprint of only 60×60 cm, enables high sample throughput,  does not need dedicated infrastructure or support, and has a projected sales price below 200 k€. This new design can serve as a unique inspection tool for nano-characterization in a broad range of technical fields, with a projected sales of 100 systems (total 20 sales price M€) per year. The new design will integrate a table-top electron microscope with a newly designed light collection and analysis system designed together with the company Delmic. The CL microscope demonstrator system will be used to perform test measurements for industrial customers in two beachhead markets to explore the market need for the new instrument and to create strong feedback of initial users on the demonstrator design. Knock-on benefits in the academic market are also expected. If successful, the project can be taken to full commercialization through the company Delmic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Water - Sustainable Point-Of-Use Treatment Technologies' under Horizon 2020.

assistant: **Concept**

The WHO estimates that in 2015 in Africa ~156 million people relied on untreated sources for their drinking water. WATERSPOUTT will design, develop, pilot and field-test a range of, sustainable point-of-use solar disinfection (SODIS) technologies that will provide affordable access to safe water to remote and vulnerable communities in Africa and elsewhere. These novel large-volume water treatment SODIS technologies will be developed in collaboration and consultation with the end-users, and include:1. HARVESTED RAINWATER SODIS SYSTEMS for domestic and community use. (South Africa, Uganda). 2. TRANSPARENT 20L SODIS JERRYCANS. (Ethiopia)3. COMBINED 20L SODIS/CERAMIC POT FILTRATION SYSTEMS. (Malawi)These are novel technologies that will create employment and economic benefits for citizens in both the EU and resource-poor nations. WATERSPOUTT will use social science strategies to: a. Build integrated understanding of the social, political & economic context of water use & needs of specific communities.b. Examine the effect of gender relations on uptake of SODIS technologies.c. Explore the relevant governance practices and decision-making capacity at local, national and international level that impact upon the use of integrated solar technologies for point-of-use drinking water treatment.d. Determine the feasibility & challenges faced at household, community, regional and national level for the adoption of integrated solar technologies for point-of-use drinking water treatment.WATERSPOUTT will transform access to safe drinking water through integrated social sciences, education & solar technologies, thus improving health, survival, societal well-being & economic growth in African developing countries. These goals will be achieved by completing health impact studies of these t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Foundations for Higher and Curved Noncommutative Algebraic Geometry' (FHiCuNCAG).

assistant: **Innovation**

With this research programme, inspired by open problems within noncommutative algebraic geometry (NCAG) as well as by actual developments in algebraic topology, it is our aim to lay out new foundations for NCAG. On the one hand, the categorical approach to geometry put forth in NCAG has seen a wide range of applications both in mathematics and in theoretical physics. On the other hand, algebraic topology has received a vast impetus from the development of higher topos theory by Lurie and others. The current project is aimed at cross-fertilisation between the two subjects, in particular through the development of “higher linear topos theory”. We will approach the higher structure on Hochschild type complexes from two angles. Firstly, focusing on intrinsic incarnations of spaces as large categories, we will use the tensor products developed jointly with Ramos González and Shoikhet to obtain a “large version” of the Deligne conjecture. Secondly, focusing on concrete representations, we will develop new operadic techniques in order to endow complexes like the Gerstenhaber-Schack complex for prestacks (due to Dinh Van-Lowen) and the deformation complexes for monoidal categories and pasting diagrams (due to Shrestha and Yetter) with new combinatorial structure. In another direction, we will move from Hochschild cohomology of abelian categories (in the sense of Lowen-Van den Bergh) to Mac Lane cohomology for exact categories (in the sense of Kaledin-Lowen), extending the scope of NCAG to “non-linear deformations”. One of the mysteries in algebraic deformation theory is the curvature problem: in the process of deformation we are brought to the boundaries of NCAG territory through the introduction of a curvature component which disables the standard approaches to cohomology. Eve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'VIVA-ELISA: Advanced Laboratory Test for Rapid Detection of NLRP3 Inflammasome Activation in Critical Septic Patients' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Sepsis causes almost 20% of global annual deaths. It involves a dysregulated systemic inflammatory response driven by proinflammatory cytokines. If untreated, it progresses to organ dysfunction, low blood pressure, and septic shock. Current diagnosis methods have low predictability, delays in diagnosis, lack of sensitivity, and an inability to predict the course of the patients deterioration: there is thus a need for a rapid, accurate, affordable and early identification of the mortality risk.VIVA-ELISA is a follow-up to the ERC project SPEDI-TEST conducted at the Biomedical Research Institute of Murcia (IMIB), of which Viva in Vitro is a spin-off. Studies show that 100% of deaths of septic patients are correlated to early impairment of the NLRP3 inflammasome activation in monocytes, in the initial 24 h. A novel in vitro diagnostic method was developed for the fast detection of early impairment of the NLRP3 inflammasome activation. This method can stratify patients at a higher risk of developing life-threatening complications, resulting in an early and more accurate prognosis. VIVA-ELISA will advance this concept by developing an easy-to-use, highly sensitive immunoassay that can be seamlessly implemented into hospitals and clinics, reducing time-to-treatment, variability in data interpretation, and hospitalization costs, currently averaging $32,000 per patient. Our solution, designed as a classic quantitative sandwich ELISA, requires only a small blood sample to measure ex vivo NLRP3 activation. We aim to reduce sepsis mortality rates by 25 to 40%, reduce morbidity and recovery time, reduce chronic sequelae for patients and enable the possibility of personalized treatments and immunotherapy, while also contributing to the sustainability of healthcare systems.VIVA-ELISA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A TRranslational approach to Identify Biomarkers for Asthma and Lung function impairment'.

assistant: **Concept**

Asthma is a chronic inflammatory disease of the airways that cause symptoms like wheezing and breathlessness. In children, asthma is the most common chronic disease and according to the WHO, more than 300 million people are affected globally. There is no curative treatment available. Persistence of childhood asthma into adult life is associated with lung function impairment and increased risk of chronic obstructive pulmonary disease, COPD. Evidence is now emerging that adult diseases, like COPD, may have their origin early in life. However, there are no established biomarkers that can accurately monitor asthma progression or predict development of COPD in adults. In this TRIBAL project, I will capitalize on rich longitudinal data and repeated bio-sampling from the Swedish BAMSE study, a world-leading population-based birth cohort of 4,089 participants with a new 24-year follow-up starting in 2017. A key aim with the new follow-up is to identify young adults in their 20s with persistent asthma and pre-stage COPD by advanced lung function assessment that includes bronchodilator and nitrogen washout tests. In TRIBAL, the unique setup is deep phenotyping of these patients describing different aspects of the respiratory system, as well as molecular characteristics of relevant bio-samples and cells. Disease-related biomarkers and involved mechanisms, from gene to protein, will be identified from early childhood to adulthood. Both the innate and the adapted immune system with detailed cell characterization will be explored in relation to exposure and disease development. Specifically, with this novel approach I will address the time point during childhood when disease processes related to persistent asthma and pre-stage COPD were initiated. The ultimate goal in TRIBAL is to pr