RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Simple fusion systems and linking systems'.

assistant: **Innovation**

The classification of finite simple groups is often regarded as one of the major mathematical achievements of the 20th century. Its importance lies not only in the fundamental result, but also in the methodology and conceptual framework developed for its proof. Most intriguingly, it turned out that the structure of a finite group is closely connected to the structure of the p-local subgroups, i.e. the normalizers of non-trivial p-subgroups, for a suitably chosen prime p. Of particular importance is the prime 2. Even though the proof of the classification of finite simple groups is insightful in its major conceptual approach, it is extremely long and difficult in its details. Thus, it would be of great interest to obtain a simplified proof. Moreover, to gain the maximum benefit from the methods of the proof of the classification, it is highly desirable to work in a more general context which in particular allows also for applications in the modular representation theory of finite groups. Saturated fusion systems provide a conceptual framework for this and connect to important questions in homotopy theory. A program to find a new and better proof of the classification of finite simple groups through a classification of simple fusion systems at the prime 2 has been recently outlined by Aschbacher. Two parts of our proposal concern classification problems for fusion systems. Their significance lies not only in completing important cases in Aschbacher's program, but also in giving new insight into the relative abundance of exotic examples, i.e. fusion systems not induced by any finite group.  In the third part we attack a major problem in the algebraic theory of fusion systems by defining an analogue in fusion systems of centralizers of subgroups of finite groups. This will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An environmental modelling tool to support sustainable urban planning' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The principal aim is to develop an integrated resource flow modelling and complementary educational tool. The objective of the modelling tool is to enable planners (municipalities, architects, developers) and specialist consultants of urban (re) developments to rapidly define the mix of uses, site configuration, building design, and resource management (supply and demand) options that optimise the community's degree of sustainability (nett resource consumption and emissions) within defined economic constraints. This tool will be tested by end-users on case study sites and parametric studies will be performed to generate design guidance (pre-normative).The results plus socio-economic research, technology descriptions, reviews of technical installation/maintenance issues will inform an educational tool to provide training and guidance. By facilitating more de-centralisation SUNtool will increase security of energy supply, reduce emissions and improve local employment & social cohesion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Targeting pathological synaptic pruning by microglia in neurodegeneration' under Horizon 2020.

assistant: **Concept**

Synapse loss is the major correlate of cognitive impairment in many neurodegenerative diseases. Recent literature suggests that microglia, which mediate synaptic pruning during brain development, can be responsible for synapse loss in neurodegeneration. Although the underlying mechanisms are poorly understood, growing evidence indicates that dysfunctional microglia affect synapses number and function in pathology. Genome-wide association studies reveal that the majority of risk genes associated with neurodegenerative disorders are highly expressed in microglia. While such studies clearly implicate these cells in the pathogenesis of the disease, little is known about the causal mechanisms that link microglial risk variants to loss of synapses. We will identify the molecular mechanisms involved in microglia-mediated synapse loss. We will also generate novel in vitro and ex vivo models of ‘risk microglia’, by introducing genetic variants associated with cognitive impairment –alone or in combination- specifically in microglia, taking advantage of CRISPR/ Cas9 genome editing techniques. These goals will be achieved by combining cutting-edge transcriptomics and proteomics with mouse models of intense synaptic remodelling, to reveal the unique molecular signature of ‘shaper microglia’. A multidisciplinary approach will allow the extensive characterisation of risk models, by combining metabolic analysis, synaptic phagocytosis and degradation assays, with super-resolution microscopy, and novel genetically encoded labelling methods. With the knowledge generated here, we aim at developing and validating in vivo novel drugs- and nanobodies-based approaches for effective targeting of pathological pruning. In summary, REMIND will focus on:1) Identifying molecular players in microglia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Invisible Politics of Religion: Catholicism, Third Sector and Territory in Southern Europe' (CATSSE) targeting Seventh Framework.

assistant: **Abstract**

This research project aims at contributing to the debate over religion and politics in the EU by considering the role played by Catholicism in shaping civil society mobilizations in Southern European regions. The underlying theoretical issues of this project do refer to the classical debates about a) the weberian perspective on the elective affinities between religious ethics, economic and politics; b) the role of culture and social capital in the regional economic development; c) the neo-institutionalist debates about the interaction between the EU, state, substate public authorities and civil society actors. The project will focus on the Catholic third sector. Empirical support will be taken from fieldwork research carried out in three Southern European regions: the Basque Autonomous Community (Spain), Aquitaine (France) and Emilia-Romagna (Italy).Overall hypothesis: despite the institutional and societal decline of Catholicism, religious actors do have not renounced to interfere in public debates. Rather, they have renewed their repertoire of action when becoming civil society actors among others in a pluralistic environment. Far from being confined to the private sphere, religion still plays a significant role in the European public sphere, either as an identity resource, an ethical reference or a ritual provider. As an ethical reference, Catholicism may bias civil society mobilisations towards more caring and community-oriented dynamics and outcomes. As an organization, the Catholic Church defends both general causes and its own interests, and is involved in territorial governance networks associating civil society actors, private bodies and public authorities. This hypothesis will be tested through three case-studies: a) Historical legacy: Catholicism and the emer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quality, Utility and Maturity Measured; Developing a Data Quality and Utility Label for HealthData@EU' to be submitted under Horizon Europe.

assistant: **Abstract**

Context: Data users (i.e., researchers, innovators, regulation agencies and policy-makers) need high-quality data. In HealthData@EU, data holders are expected to make their datasets available for secondary use, providing a notion of their quality and utility and the maturity of their data quality procedures. In article 56 in the HealthData@EU proposed regulation, this notion would take the form of a label. Goal: Overall, QUANTUM aims at developing and implementing a label mechanism that could be ideally adopted in the future HealthData@EU.Methods: QUANTUM builds on 5 technical work packages (WP). WP1 conceptualises and provides technical specifications for a data quality, utility, and maturity label. WP2 designs and tests, at small-scale, the label. WP3 implements the labelling mechanism in a number of data holders. WP4 engages the data quality users’ community; and, WP5 outreaches other interested parties, including other initiatives building HealthData@EU.Expected results: a) A common concept of datasets Quality and Utility and Data holders’ Maturity; b) Technical specifications for the label (Deliverable D1.1. and D1.2); c) A conformance checking tool that yields the label (D2.1); d) An implementation report of the label mechanism (D3.1); e) Recommendations for a large-scale implementation of the QUANTUM label mechanism (D3.2); and, f) The QUANTUM Exchange Platform and Academy (D4.2 and D4.3) as instruments for capacity building.Consortium: For this purpose, 27 beneficiaries, 5 affiliated entities and 3 associated partners.  The composition of the Consortium seeks to reflect the different roles and institutions in the governance of the HealthData@EU; virtually consider all types of data and science of interest; and gather the expertise of previous outstanding project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Conference on Lasers and Electro-Optics/Europe and International Quantum Electronics Conference 2000' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

International conference on quantum electronic (IQEC) and Conference on Lasers and Electro-Optics/Europe (CLEO Europe). These two conferences are being held in Europe in the year 2000 as part of an internationally co-ordinated effort. In addition to similar conferences held in US and Japan with a steadily increasing growth, it is essential to bring these events to Europe at regular intervals to foster European collaboration and improve the international visibility of European research in the fields of laser technology, non linear optics, optical materials and sensors, devices for optical switching, the biomedical applications of optics, cold atoms, quantum optics, ultrafast phenomena. While in general European research is at the forefront on all these topics, until the present series was started, communication used to be organized around events in United States.At present, in addition to an US version of CLEO which is held annually, CLEO is organized in Europe every two years. The International Quantum Electronics Conference IQEC comes to Europe every six years in a cycle involving the US, Japan, and Europe. IQEC 2000 and CLEO Europe 2000 will be held jointly in Nice in September 2000. In additional to over 1000 communication devoted to new research and selected by a programme committee using strict guidelines of originality, clarity and relevance, the two conferences include invited papers, plenary lectures, a tutorial programme and so-called tech focus" sessions, that all contribute to the training aspects of the event. Although they are part of co-ordinated series, the present proposal refers specifically to the CLEO/Europe and IQEC conferences to be held in Nice in the year 2000.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00087-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Workplace as a Site of Political Preference Formation. How ‘Bridging Institutions’ Strengthen Democracy.' (BridgeDem) under Horizon Europe.

assistant: **Objectives**

How does the changing organization of work affect political conflict in advanced democracies? While we know much about the impact of labor markets on political attitudes and behavior, the workplace as a site of preference formation is largely unexplored – even if this is where a majority of people spend most of their awake time, experience contact and collaboration within and across status groups, and exchange about society and politics. BridgeDem argues that social relations at work impact affective polarization, preferences for redistribution, and support for populism, and that changing workplaces have exerted a major influence on these outcomes. Linking political behavior and political economy literatures with sociology of work & organization, it explores this argument in three ways, studying how (1) changing management styles (2) increasing vertical segregation between status groups and (3) increasing horizontal segregation between social groups in companies have impacted the political outlook of the employed. These inquiries contribute to the encompassing endeavor of building a theory of ‘bridging institutions’ – institutions that set different groups within a society into meaningful social contact and by doing so foster democracy, the workplace serving as a crucial yet underexplored case. To do so, this project leverages an innovative and mixed methodological strategy, combining (a) theory development on the basis of in-depth qualitative interviews with (b) causal identification by matching administrative employer-employee datasets with individual-level panel surveys (SOEP-IAB; LISS-CBS) and (c) assessing long-term trajectories across countries and sectors using administrative and cross-sectional survey data. This comes with an outreach initiative to unions, HRM a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Eco-friendly and high-performance thermal insulating fibre reinforced mortar to be applied on walls as a coating or panel', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

One of the priorities of the 2030 Agenda is to achieve a sustainable development path to balance environmental, social and economicneeds for present and future generations. The United Nations Sustainable Development Goals (SDGs) are the blueprint to achieve abetter and more sustainable future. The Green Deal is the roadmap towards the application of the 2030 Agenda and the SDGs in allEuropean policies. In this context, the European construction industry faces great challenges that need real solutions. On theenvironment side, it is clearly a sector with an unsustainable environmental profile that will need to overcome the traditional linearpath of production and consumption to adopt a Circular Economy model and Energy Efficient solutions. The number of studies onnew sustainable solutions to minimize the incorporation of processed raw materials or improve thermal insulation properties ofmortar have increased. Examples relate to the use of stone sludge waste from the cutting process as filler in rendering mortars orfibres from textile waste to reduce its cracking or to the increased insulation of rendering mortars through the incorporation of cork(recycled by-product of the cork industry) or silica-based aerogels (nano-structured material) as lightweight aggregates. However,studies focused on combination stone sludge waste, textile waste, recycled cork together with aerogel in mortars have not beenfound in the current literature.The main objective of the Eco-Mortar 2.0 project is to develop an eco-friendly and high-performance thermal insulating fibrereinforced rendering mortar for wall exterior retrofitting or wall panels coating of buildings by using diabase sludge from stonecutting as filler, recycled cork and aerogel granules as lightweight aggregates and textile waste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Engineering, production and life‐cycle management for the complete construction of large‐length FIBRE‐based SHIPs'.

assistant: **Innovation**

The main objective of the FIBRESHIP project is to create a new EU-market to build complete large-length ships in FRP (Fibre-Reinforced Polymers) enabling its massive application. In order to achieve this objective, the project will develop, identify and qualify FRP materials for different applications in particular for long-term structural strength and fire resistance. In addition to this, its massive application also requires elaborating innovative design procedures and guidelines supported on new validated software analysis tools. Standardized efficient production methodologies will be implemented and demonstrated by delivering a proof of concept. Clear performance indicators will be designed and applied in the evaluation of three targeted vessels categories (container ship, ferry and fishing research vessel) to be developed within the project.The project will also analyze the life cycle cost benefits of incorporating FRP materials in large-length ships, developing a business plan for the different actors in the value chain. The business plan will cover the different phases of the life cycle from design, engineering, material production and shipbuilding to the final dismantling of the vessel.The use of FRP materials in large-length ships will imply a significant weight reduction (about 30%) and a relevant impact in fuel saving, ship stability, environmental impact (reducing greenhouse gas emissions and underwater noise), and increase of cargo capacity. On the other hand, FRP materials are immune to corrosion and have a better performance under fatigue type loads, what means better life performance and reduced maintenance costs.The mid-term impact is estimated in about 5% of the total shipbuilding market in Europe (turnover about €2.0Bn), and it is envisaged a long ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Inhibiting BAF to Improve Gene Delivery', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Safe and efficient delivery of nucleic acids to tissues and cells is a shared challenge in the clinical translation of gene therapy and gene editing. At the intracellular level, DNA delivery is hindered by endo/lysosomal sequestration, inefficient transport into the nucleus and a retention mechanism mediated by the barrier-to-autointegration factor (BAF) protein that detects, clusters and locks away intruding double-stranded DNA in membrane cages. The first two of these intracellular obstacles are well-known bottlenecks and are being addressed by many laboratories. However, preliminary in vitro data suggest the detrimental impact of BAF’s mechanism on transgene expression is underestimated. We hypothesize that transiently suppressing BAF or one of its regulating factors will increase the cytosolic availability and mobility of transfected DNA, facilitating its transport to the nucleus and ultimately boosting transfection efficiency. We will tackle this rather uninvestigated mechanism through two parallel strategies: i) identifying novel small-molecule inhibitors of BAF or its regulators via high-throughput screening of chemical libraries, and ii) producing a recombinant kinase that phosphorylates BAF in situ and thus supresses its DNA-clustering function. The BAF suppressors will be co-delivered to cells with rationally-designed nucleoprotein nanoparticles consisting of a reporter plasmid and a dual-function fusion protein to facilitate endocytosis and endosomal escape. The combined transfection-enhancing effect of the BAF suppressors and the nanoparticles will be extensively characterized in vitro, and in vivo proof-of-concept will be obtained in mice. Besides expanding our fundamental knowledge on this unexplored DNA retention mechanism, the project will provide powerf