RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intelligent PPE system for personnel in high risk and complex environments' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main objective of the 4-year project is to develop intelligent personal protective equipment (PPE) system that will ensure active protection and information support for personnel in high risk and complex environments, in particular chemical rescue teams, firefighters and mine rescuers, who are exposed to fire, explosions, high temperature, dangerous substances, limited visibility, high humidity and limitation of breathable air. These high-level risks are reflected in a significant number of injuries and fatalities reported in the target sectors. The S&T objectives of the project are: - to integrate, within the new PPE system, state-of-the-art materials, active textiles, optical fibre sensors, gas and temperature detectors, ICT - to develop new materials (based on nanotechnology) and integrate them into PPE elements in order to enhance multi-functionality and adaptability; - to assure ergonomic design of new PPE and validate its functionality, safety, comfort and performance level by usability tests in real working conditions. The project is divided into 4 phases: 1) Conceptualization; 2) Technical development and integration, 3) Verification and validation; and 4) Dissemination and exploitation. The consortium consists of 16 partners from 6 countries: 5 RTDs, 8 SMEs, 2 industrial companies and 1 non-profit organisation. Three partners representing target groups participate in the whole project to guarantee full adaptation of the PPE system to users' needs. The project will have an impact on: the reduction of occupational injuries and disease in the EU (the population of end-users estimated at 3-5 mln.); European regulations (PPE Directive) and harmonised EN standards; European leadership in PPE-related research and innovation; the growth of European PPE market and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploitation of Glycosylation Signatures for Precision Medicine' (GlySign) targeting Horizon 2020.

assistant: **Abstract**

GlySign is a research training network for the translation of glycomic clinical biomarkers for Precision Medicine (PM). Complex, distinctive changes occur in the glycomics profiles or - Glycan Signatures - of human glycoproteins during progression of many chronic diseases including cancer and inflammatory conditions. The three beneficiaries of the GlySign Consortium have been instrumental in contributing to knowledge in this field through development of glycomics technology and discovery of clinically important novel glycan biomarkers in a variety of diseases. Glycan signatures have great potential for adding useful diagnostic and prognostic information in PM. However, advancement of this field is slow because (a) glycans have immense structural complexity resulting in major technical challenges for their analysis and (b) there is a lack of experts with required glycoanalytical skills. GlySign will address this gap by training six young scientists within an innovative training-by-research programme with high industrial-academic mobility to eventually push forward the translation of novel glycomics-based diagnostic tools into clinical practice. This will be achieved by further developing a range of selective and sensitive glycomics technologies for the analysis of samples from patients and healthy controls in close collaboration between industry/academia as well as clinical chemists and clinicians who will be the end users of GlySign’s final products. To this end, we will focus the training on clinical glycomics applied to four model diseases implicating changes in the glycosylation of circulating proteins specific to disease progression or subtype, i.e. diabetes, prostate cancer, fetal and neonatal alloimmune thrombocytopenia and rheumatoid arthritis. Due to its strong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dark Matter and the Early Universe in the LHC Era' (DARKHORIZONS).

assistant: **Concept**

The discovery of a Higgs like particle in its first science run shows that we are truly in the LHC era and when collisions resume we will learn more about the physics of the TeV scale.  There are two main areas at the interface of particle physics and cosmology that the LHC will shed light on - If dark matter is a thermal relic then we naturally expect new particle physics close to this TeV energy range.  The LHC will also help us learn about the nature of the electroweak sector and its behaviour during the early Universe.In this proposal we present a body of work which will combine information from the LHC with dark matter experiments and astronomical observations to understand both the nature of dark matter and the role of the Higgs sector in the first moments after the big bang.  We will investigate dark matter by developing a new categorisation of interactions between the dark sector and the standard model.  This will enable us to perform detailed collider and direct detection phenomenology in a more comprehensive way than current approaches while avoiding the problems which occur when those methods breakdown.  Different schemes for mitigating against the upcoming problem of the neutrino floor in direct detection experiments will also be investigated.Many of the keys to understanding the particle nature of dark matter lie in astrophysics, and we will develop new techniques to understand the distribution of dark matter in the Universe, its behaviour and density in distant galaxies and its velocity dispersion in the Solar system, critical to predict event rates in detectors.We will use LHC and CMB data to answer important questions - Can the electroweak phase transition be first order?  What is the role of the Higgs field during inflation?  Can we use the electroweak
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Expanding the genome editing toolbox by rational reprogramming of tyrosine recombinase DNA specificities'.

assistant: **Innovation**

Gene therapies aim to cure genetic diseases by modifying the DNA blueprint. An ideal gene therapy should be durable, safe, and efficient, which often requires integration of large therapeutic DNA cargo at precise genomic locations. Advanced DNA editors with programmable specificities, such as the CRISPR technology, are limited by the nuclease-based mechanism and poor efficiency of large DNA insertions. Increased efficiency, specificity and precision of large edits are required to address a broad therapeutic space.Tyrosine recombinases (YRs) efficiently rearrange large DNA segments without the pitfalls of nuclease-based editors, but with an important caveat – rational reprogramming of their specificities for binding non-native DNA targets is an unsolved problem. EditYR ambitiously aims to develop a rationally programmable tyrosine recombinase platform for efficient integration of large DNA cargo into precise genomic locations. EditYR will expand recombinase engineering capabilities by exploiting the recent advances in large scale DNA synthesis and sequencing coupled with bioinformatics and innovative protein design. Objective 1 will engineer tyrosine recombinase DNA specificities and extract a comprehensive DNA recognition code. Objective 2 will modify their oligomerization properties to enable binding non-palindromic targets, allowing targeting any desired nucleotide sequence. Objective 3 will investigate requirements for irreversible recombination to maximize integration efficiencies and unlock the full therapeutic potential of these enzymes. Finally, Objective 4 will validate engineered enzymes by identification of targetable sequences in therapeutically relevant genomic regions and integration of therapeutic DNA cargo in various human cell types for different disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Wireless Software and Hardware platforms for Flexible and Unified radio and network controL' to be submitted under Horizon 2020.

assistant: **Abstract**

Wireless testbeds have become an essential tool to develop and validate innovative wireless solutions. However, due to the increasing diversity of wireless solutions and competing radio technologies, along with the ever more stringent requirements on the reliability of test results, wireless test facilities have evolved to very complex systems with steep learning curves for innovators. To speed up and facilitate the experimentation process, to lower its cost and to enhance the uptake of future non- and pre-standard solutions, the WiSHFUL project is determined to lower the experimentation threshold by developing flexible, scalable, open software architectures and programming interfaces for prototyping novel wireless solutions for a variety of applications ranging from healthcare to smart cities, supporting players in high value-add markets with considerable growth potential.Key features of WiSHFUL include (1) unified radio control, providing developers with deep control of physical and medium access components without requiring deep knowledge of the radio hardware platform and (2) unified network control allowing the rapid creation, modification, and prototyping of protocols across the entire stack.WiSHFUL will also create a testbed-on-the-move, consisting of portable facilities that can be deployed easily and efficiently at any location, allowing validation of innovative wireless solutions in the real world (with realistic propagation and interference characteristics) and involving real users. The usefulness of these facilities will be confirmed by participation of industrial and academic partners through open calls for experimentation.In addition, we envision to extend these facilities with the capability to experiment with emerging wireless technologies such as millim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Retinal development in flat fish larvae- the effect of dietary essential fatty acids' (RETDEV) under Sixth Framework.

assistant: **Objectives**

The current proposal seeks to evaluate the effects of highly unsaturated fatty acids (HUFA) on the development of vision in marine fish larvae. The study will consider the effect of natural diets with differing contents of HUFA on the development of the retinal tissue in larvae of the flatfishes Pleuronectes platessa and Paralichthys orbignyanus.HUFA play an important role as an energy storage and membrane components, including photoreceptor cells in the retina. Marine fish have a limited capacity to synthesize HUFA and must acquire them through the food. The need is critical in fish larvae because of the rapid growth and the critical development of specialized tissues. We expect that larvae that feed on prey with high content of docosahexaenoic acid (DHA) will have a better configuration of the retina and lipid composition than larvae raised on a low-DHA diet and that this should affect their vision, feeding capability and fitness.The project will be carried out at the Department of Marine Ecology, Goteborg University at Kristineberg Marine Research Station during the two-year incoming phase and in Faculty of Science, Universidad de la Republica during the one-year returning phase. The objective of the present study is to assess the effect of diets with differing contents of HUFA on the development of the retinal tissue in larvae of flatfishes from different estuarine systems: Gullmarsfjord (Sweden) and micro-estuaries along coast of Uruguay. Specific objectives are:1) To analyse the evolution of the retinal tissue structure in larvae of P. platessa (in laboratory) and P. orbignyanus (in situ) at different stages of development subject to diets of differing HUFA contents.2) To characterise the HUFA profiles in the retina of P. platessa and P. orbignyanus larvae at diff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The NIMBLE System: A novel non-invasive and non-ionizing medical device for the continous monitoring of patients with implanted cardiovascular stents""""' to be submitted under Horizon Europe.

assistant: **Abstract**

At NIMBLE Diagnostics we are developing a first-in-class microwave-based medical device for the non-invasive and non-ionizing monitoring of patients with implanted stents.Stents are one of the most implanted devices worldwide and are used to re-open blocked arteries and restore the correct flow of blood or other fluids. They are especially useful to prevent heart attacks or to treat their lasting symptoms, but, after implantation, become blocked or damaged in 30% of cases. Symptoms only appear after a stent is already 90% dysfunctional, which increases the incidence of serious complications, including strokes, heart attacks or sudden death. Diagnosis of malfunctioning stents is still symptom-driven and is based on an invasive procedure called catheter angiography, involving anesthesia, X-ray exposure and 24h hospitalization recovery. This complex, costly and invasive procedure is not appropriate for ongoing monitoring, which is why the standard of care only reacts when patients already have potentially life-threatening symptoms.The NIMBLE System can read the electromagnetic signature of any stent non-invasively in less than 5 seconds and can be used to provide information on stent status and malfunction during regular clinical visits. Thus, NIMBLE enables early treatments to prevent negative outcomes and personalization of therapy, shifting from reactive to proactive care.Our technology is currently at TRL5/6, with an MVP that has shown excellent results in pre-clinical validations. We have also started the first-in-human testing in a pilot study of 30 patients that will finish early 2024.The EIC Accelerator program will allow us to bridge the biggest risk of our project by performing the regulatory clinical trial to obtain the CE mark, as well as support us to create a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of the antiviral RNA interference response in the C. elegans–Orsay virus pathosystem', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Viruses infect all known living organisms, and the RNA interference (RNAi) response is one of the main defense mechanisms cells use against viruses. Even though we have a general understanding of the players involved in the antiviral RNAi response, with some systems more characterized than others, we still lack mechanistic details about the process. For example, in the C. elegans-Orsay virus pathosystem, loss of certain RNAi proteins can be advantageous for the virus, but it is still unclear whether this is because the virus highjacks the RNAi machinery for its own advantage or because the absence of certain RNAi proteins frees up resources which can then be used for antiviral defense. Moreover, preliminary results show that there are distinct viral RNAi silencing complexes, but the composition and function of these complexes is still unknown. Finally, the RNAi response seems to prevent multicellular viral colonization through yet unidentified mechanisms. In this proposal we aim to address these three open questions to improve our understanding of the role of RNAi in the defense response to a viral infection. We will perform a comprehensive analysis of the antiviral RNAi pathway and the Argonautes – the main effectors of the RNAi pathway –, their interactors and targets upon Orsay virus infection. We will use a multidisciplinary approach, combining in-depth analyses from virology, cell biology, genetics, genomics and developmental biology. This will be possible due to the collaboration between the researcher and the laboratories of Prof. Elena, the coordinator and virology expert, and Prof. Claycomb, the outgoing phase host and cell biology and small RNA regulation expert. The expertise the researcher will obtain goes beyond the research in either laboratory and will he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Humanities Rock! Research: Shaping the Future of Humanity' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The HUMANITIES ROCK! ERN 2024-2025 builds upon the successes of the 2018-2019, 2020, and 2022-2023 editions, all organized by the University of Ljubljana. Our core mission remains consistent: to facilitate closer interaction between research and the general public. Our overarching objectives persist: to enhance understanding of research and innovation activities, to bolster public recognition of science and research education, to underscore the researcher's role in society and the economy, to showcase the tangible impact of research on daily life, and to inspire young individuals to consider research and scientific careers.In an era where science denialism and skepticism towards scientists are prevalent, often attributed to academia's hesitance to engage with the broader public, our 2024-2025 edition unites STEM and SSH disciplines with the explicit goal of bringing research and researchers to the forefront. Our aim is to establish direct channels of communication with the general public, reinstating credibility and trust in research, innovation, and those who drive these efforts, while promoting public recognition of science and research education.The 2024-2025 edition focuses on the expansive theme ""RESEARCH: SHAPING THE FUTURE OF HUMANITY."" This theme underscores research's pivotal role in shaping society's future and generating sustainable impact. It aspires to mobilize citizens, encouraging them to embrace innovative solutions and approaches, while fostering greater societal acceptance and engagement with science and research.Our planned activities are particularly geared towards children, young individuals, and those who may typically be less inclined towards science. These activities encompass shows, competitions, exhibitions, lab visits, workshops, discussions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Logics for Computer Science Program at TU Wien' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The Logics for Computer Science Program at TU Wien (LogiCS@TUWien) will be a top international graduate program implementing a unique combination of disciplines where logical methods have a decisive impact on practical computer science and society in the coming decades.  Leveraging a multitude of existing grants, initiatives, and collaborations, the LogiCS@TUWien program will match research strength with a doctoral program of strong international visibility that is highly attractive to excellent students. The 13 experienced doctoral supervisors are world leading experts in their respective fields, who attracted significant funding achievements in recent years, including 4 ERC grants, 5 Austrian grants of similar endowment and competitiveness, and a grant for a highly successful doctoral college on Logical Methods in Computer Science (funded from 2014 to 2022), which has attracted 78 brilliant doctoral students.  The proposed program improves significantly over this predecessor program, in particular by adding a strong focus on intersectoral exposure and collaboration. The research topics in the field of Artificial Intelligence, Databases, Verification, Algorithms, Security, Distributed and Cyber-physical Systems are driven by demand from industry and real-world problems. This is enabled by the supervisors' strong ties to industry, as evidenced by their spinoffs, and by the regular internships of their doctoral students at research labs of major companies at national and international levels.  LogiCS@TUWien will achieve long-term impact by institutionalizing a high-quality PhD program following the seven EU Principles to ensure an innovative doctoral training, and will create a hub in Austria and Europe for logic-related education and training. Interdisciplinarity, a hol