RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Single Polaron Tracking' under Horizon Europe.

assistant: **Concept**

Polarons are quasiparticles that form in ionic lattices due to the coupling of excess electrons or holes with lattice vibrations. This leads to a spatial confinement of the charge carrier or even its complete localization, which presents a challenge for theoretical modelling. Polarons play a central role in many materials properties, such as electrical transport, optical properties, surface reactivity, or magnetoresistance, and are always investigated indirectly through such macroscopic characteristics. Here, I propose to develop a methodology for real-space experimental observation of single polarons, based on detecting their electrostatic force by noncontact Atomic Force Microscopy (nc-AFM). I will track localized polarons in the crystal lattice, observe their thermally activated hopping, interaction with light, electric and magnetic field, and coupling to lattice defects. This will provide the missing link between the atomic-scale polaron dynamics and macroscopic materials properties.The nc-AFM represents an excellent tool for watching and explaining the fundamental mechanisms involved in polaron kinetics, yet the method has a limited time resolution. I propose overcoming this limitation by combining nc-AFM with excitation by light, aiming for time resolution of 10-6 to 10-9 s, while maintaining the atomic resolution in real space through plasmonic effects at the tip apex. This will allow investigation of highly mobile polarons that stand behind complex physical phenomena, resolve their mechanisms of charge transport, the nature of their excited and transition states, as well as polaron-polaron interactions. If successful, the result of this project will provide a big leap towards understanding the physics of charge carriers in ionic lattices, open a path towards exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Interactive networked kiosks' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objective of the INK Project is to develop a system for POS/POI (Point of Sale / Point of Information) networked applications where access to multimedia data is provided from a number of interactive terminals connected to one or more video servers.Low cost, Windows-based terminals will be employed, either by the user company staff, or directly by the customer. Real-time MPEG compression / decompression will be used to reduce both storage requirements and transmission bandwidth. Limited authoring facilities will be available for the quick modification of both the video database contents and the application structure.An ATM based network will be provided for accessing multimedia information. However, lower bandwidth multiplexed access will be used for connecting the POS/POI terminals to the ATM switching equipment, both to optimise bandwidth utilisation and to reduce the cost/terminal ratio of the system.Two pilot applications will be built in two different sectors: one for the high quality hospitality sector and the other for sales support.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Simulation studies of the relationship between ligand induced rearrangements of enzyme loops and high ligand selectivity' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Enzymes are fascinating macromolecules because they present high specificity toward their physiological substrates and in the same time they show high flexibility during catalysis. In particular, experimental studies evidenced the role of loop dynamics in the binding affinity and specificity of the substrate. Such conformational changes on loop would be induced by ligand approach. The objectives of the project are to understand the induced-fit mechanism upon ligand binding and to characterize the tight link between loop rearrangements during association and high ligand selectivity using theoretical approaches. Loop movements generally cover time scales not reachable by classical molecular dynamics simulations. Consequently, we will need to define a novel pro tocol inspired from advanced molecular dynamics, successfully used in simulations of protein folding. This work will build upon expertise in the outgoing laboratory and will be carred out on selected glycosidases studied experimentally and theoretically in the return laboratory. Results will be compared to those obtained by a new robotics method developped in the return laboratory and able to simplify large-scale motions by geometric analysis. Enhancing our knowledge of the induced fit mechanism should be v ery useful to enzyme engineering, since loop movement is often a key element of enzyme activity. Controlling loop flexibility during association should permit to design or alter enzyme function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Learning in partnership: responding to the restructuring of the european steel and metal industry'.

assistant: **Concept**

The project will provide insights into the European challenge of developing learning strategies that enhance employability and help manage change. Focusing on the steel and metal sectors, the research will evaluate the role new learning strategies can play as a response to restructuring and will examine the potential of partnership-based approaches for furthering learning issues. It aims to map the learning implications of restructuring, document the learning experiences of workers and evaluate the role trade unions can play in promoting partnership-based responses. Empirically, it involves detailed workplace case studies and an innovative biographical study of displaced workers. At a conceptual level, the project will produce a comparative report documenting potential European frameworks and provisions for lifelong learning. Practically, the project will develop European Skills Charters for the steel and metal sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modulating the gut microbiome to enhance drug efficacy' (BugDrug).

assistant: **Innovation**

Individual response rates to drugs that are widely prescribed to treat common diseases are typically in the range of 50-75%, yet the slow progress and high costs associated with new drug development do not meet the urgent need for new treatment options, particularly given the rapidly increasing burden of chronic diseases.  This ERC project tackles this pressing issue by defining the impacts of the gut microbiome and genetics on drug metabolism, ultimately enabling personalized approaches that enhance efficacy and safety of already marketed drugs via microbiome modulation. I will start with 23 common drugs used to treat chronic cardiometabolic and psychiatric disorders that threaten public health. The project will address important technical and clinical challenges in three innovative parts: 1) a population-based cohort study using the unique LifeLines-10K cohort to build sophisticated models that take genetic, microbial and lifestyle/health factors into account to improve prediction of drug metabolism; 2) pharmacokinetics analyses using innovative, personalized organ-on-a-chip to better understand causality and mechanism; and 3) an intervention trial using probiotics to achieve greater drug efficacy through modulation of the gut microbiome. In particular, the project will deliver microbiome-targeting solutions to improve the efficacy and safety of one or two drugs and a next-generation drug-testing model that uses an innovative organ-on-a-chip system to mimic metabolic flow along the gut-liver axis while taking an individuals genetics and gut microbiome into account.  This project will lay the foundation for major advances in personalized medicine through: (i) better prediction of individual drug metabolism, which will aid therapeutic decision-making; (ii) better unders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Evolutionary dynamics of pancreatic cancer at single-cell and spatial levels'.

assistant: **Objectives**

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, a disease with a dismal prognosis. PDAC has an especially high tendency of quickly metastasizing and becoming resistant to therapy, and the mechanisms by which this occurs are largely unknown. Recent evidence suggests that saltatory or burst-like evolution mediated by complex genomic rearrangements (CGRs) may be especially relevant in PDAC, altering multiple cancer genes in a single event. However, quantifying CGRs requires specialized techniques (such as Strand-Seq), and therefore the relative importance of CGRs, simple structural variants, and point mutations in PDAC evolution remains unclear. In this project, we will use a genetically engineered mouse model (GEMM) that develops de novo PDAC to longitudinally track PDAC evolution by single-cell and spatial multi-omic methods, using Strand-Seq to accurately detect CGRs. Thus, we aim to create longitudinal single-cell and spatial multi-omic atlases of PDAC at three key evolutionary steps: pre-cancer, therapy-naive PDAC, and post-therapy PDAC. In addition, we will compare our atlases to human PDAC data from the Spatial And Temporal Resolution of Intratumoral Heterogeneity in 3 hard-to-treat Cancers (SATURN3) Consortium. In this way, we will model PDAC evolution at various time points, quantifying the relative importance of gradual vs saltatory evolution and determining how evolvability changes over time. Moreover, we will infer the role of selective pressures from the tumor microenvironment (e.g., immune cells and cancer-associated fibroblasts) in shaping PDAC evolution. Finally, we will explore how all these factors interact with the high intratumoral heterogeneity observed in PDAC. Overall, this project will answer long-standing quest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Beta cell preservation via antigen-specific immunotherapy in Type 1 Diabetes: Enhanced Epidermal Antigen Delivery Systems' (EE-ASI) targeting Seventh Framework.

assistant: **Abstract**

Current  approaches to improving glycaemic control in type 1 diabetes are centered on increasingly complex insulin delivery systems. However,  less  than 30% of patients can achieve target  levels of glucose control with this approach even  in a clinical trial setting  and many patients are either unable or unwilling to make  the personal commitment required. By contrast, preservation of even  small amounts of endogenous insulin production, has been shown  to improve glycaemic control, reduce hypoglycaemia, improve quality of life and reduce long-term complications. Importantly, glycemic control in the presence of endogenous beta  cell function is not demanding and hence would be effective across the full spectrum of individuals.  Antigen specific immunotherapy (ASI) is the preferred approach to beta  cell preservation since  this avoids  the risks of immunosuppression. Attempts  at ASI to date  although successful in preclinical models have  had limited efficacy in humans. There is therefore an urgent need for the development of novel approaches to deliver effective ASI.Our Enhanced Epidermal – Antigen Specific Immunotherapy (EE-ASI) system represents an innovative  approach to ASI created by combining  technologies brought  by our academic and 2 SME partners. A beta  cell target  T cell epitope (proinsulin C19-A3) will be combined with the tolerogenic cytokine IL-10 and targeted to antigen presenting cells via gold nanoparticles and delivery into the very superficial  layers  of the skin using microneedles. Validation of manufacture, in vitro and in vivo preclinical efficacy will be demonstrated followed by a phase 1 clinical trial to confirm safety  in humans.We anticipate that the EE-ASI system will be less  costly, more effective and more acceptable to patients in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Flexible Approaches to Support Health through financing' in the context of a Horizon Europe call.

assistant: **Objectives**

One of the lessons learnt from the Covid-19 pandemic is the importance of flexibility in funding and organization of health systems. European countries responded quickly to this extreme event, by expanding the amount of financial resources available for health care and reallocating financial and human resources. However, there are several other challenges for health care systems that require efficient and flexible financing mechanisms to be successfully addressed. This project undertakes a comprehensive analysis of health care financing mechanisms in Europe, by focusing on the two key stages of the process: i) budget allocation (e.g., among managing authorities, clinical areas), ii) financing of health services within a specific budget, through the definition of contracts and payment rules. We identify and examine the most prominent mechanisms underlying the relationship between the main challenges faced by health care systems (demand shocks, ageing, budget pressure) and their financing. By employing a wide range of methodological approaches, we provide evidence on the ability of existing financing mechanisms and contracts to address such challenges and study new solutions to achieve more effective, efficient and equitable health care systems.


**Keywords:** Financial allocation criteria, Pay-for-performance, Resilience, Integrated care, Digital health, Patients mobility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'ADVANTAgeous applications of GAS sensors for security and consumer applications'.

assistant: **Objectives**

The aim of this project is to develop new gas-sensitive field effect transistor microsystem set up. This device is most suitable for consumer applications where especially the device costs (<2 Euro) and low power consumption (<1mW) are major requirements. The low power operation is possible using functional materials designed for an ambient operation temperature. The low price of the device is reached by developing material technology for flip chip sensor setup, which has a common silicon part in standard CMOS for various applications and gives full freedom in preparation technique for the sensitive films. The device is most suitable for hand-held gas detectors.The functionality of this device will be shown during field tests in one pilot applications: Work place safety with respect to hazardous gases and fire. Additionally standardised test procedures will be developed and applied to the gas sensors according to the specifications of this application.Objectives:1) The development of a gas sensor that is a low costs (<2 Euro) and low power (<1mW) device will open new market opportunities like portable gas warning systems for the professional and consumer market;2) Sensor systems with that device will be adopted to the pilot application work place safety with respect to fire detection and hazardous gases with the target gases CO2, CO, NH3, NOx and ozone in ppb and ppm range;3) Standardized test procedures are developed and applied to the sensors;4) Opening up additional markets will distinctly influence the employment by creating high level jobs in Europe at OEM (which are mainly SME´s). The market of all possible applications is regarded to be of several 100 mio Euros;5) The use of the gas sensor system will impact the safety of people at work and at home and will save
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'INNOVATIVE SMART COMPOSITE MOULDS FOR COST-EFFECTIVE MANUFACTURING OF PLASTIC AND COMPOSITE COMPONENTS' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Currently, composite moulds are mainly used in open-mould manufacturing processes and in Light RTM (a low-pressure variation of RTM). The proposed project aims to extend the applicability of composite moulds into the more demanding regime of RTM production, as well as to extend the application of the open mould and light RTM techniques in the field of advanced resin systems, where elevated temperature is required. Most important Innovations are: i. embedded heating elements, based on the carbon reinforcement of the mould, close to the mould-part interface demanding less energy. ii. Incorporation of flow, temperature and cure sensors that will enable full automatic control of the process. iii. Layout of a cooling system consisting of a conformal (following the contour of the part) tubing network. iv. Use of piezoceramic film actuators which will induce micro-vibrations and thus assist resin flow inside the cavity. Such actuators on the edges, can be used for demoulding thus reducing tool complexity and demoulding time. Integration of these functionalities into a single “smart” mould is anticipated to impart a significant advancement of the composite and plastics manufacturing industry. It is obvious that by lowering the cost of the moulds the application of high end composites into the sectors of aerospace and automotive industry widens, serving weight reduction and the greening of the transport sector while extending the use of composites in other industrial sectors such as leisure and sport, the energy sector etc. Managing to develop composite moulds for the demanding RTM field, would automatically make them available for other manufacturing processes for engineering plastics and composites (RIM, Transfer moulding, Resin Infusion). While the current project will occupy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a cost-effective anti-bacterial device for the 37 million urethral catheters used in enlarged Europe' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

A survey conducted by WHO showed that 2,4 million of European patients suffer nosocomial infections every year. Urinary Tract Infections (UTI) account for approximately 40% of nosocomial infections; 80% of UTIs are associated with the use of indwelling urethral catheters. UTIs related to indwelling catheterisation prolong the mean length of hospitalisation, ranging from 2.4 to 19.8 days; 2 Billion Euro is the associated annual direct cost for National Health Services. Furthermore catheter associated UTIs are responsible for increased hospital mortality; the infection proves in fact fatal for around 30,000 people in Europe every year.  Two routes of entry of uropathogens to catheterized urinary tracts exist: 1) extraluminal contamination may occur early, by direct inoculation when the catheter is inserted, or more frequently, by organisms ascending from the perineum by capillary action in the thin mucous film contiguous to the external catheter surface; 2) intraluminal contamination occurs by reflux of microorganisms gaining access to the catheter lumen from failure of closed drainage or contamination of urine in the collection bag. While extraluminal infection route was blocked by coating the external catheter walls with hydrogel-silver films that reproduce the natural barrier mechanism of urethra physiology, no effective solution exists today to avoid intraluminal infections.  The overall objective of the project is to develop a cost-effective device able to create a barrier that avoids migration of the bacteria intraluminally. The proposed concept is based on a plastic cage whose internal walls are covered with a thin film of photocatalytic TiO2 (anatase), triggered by inexpensive low energy UV LEDs powered by coin cells commercially available for watches or calculato