RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Mending sex differences: Unravelling the female predominance in pulmonary hypertension'.

assistant: **Objectives**

Pulmonary hypertension (PH) is a rare but progressive fatal disease characterized by accumulation of persistently activated cell types in the pulmonary vascular wall exhibiting abnormal expression of genes driving proliferation, inflammation, and metabolism. The currently used vasodilatory therapies have little or no impact on this activated phenotype and therefore offer no cure or even substantial survival benefit. PH has a high female predominance (3:1 to 9:1). This proposal aims to understand the mechanism behind the high female predominance to identify novel therapeutic targets to attenuate disease progression in male and female PH patients. Female predominance can be linked to sex hormones and/or incomplete X chromosome inactivation (XCI) leading to biallelic expression of immunoinflammatory and metabolic genes. To understand the impact of oestrogen and androgen signalling on abnormal vascular remodelling in PH, I will develop a unique opposite-sex lung transplantation rat model, identify oestrogen metabolites in a large set of patient serum samples and explore their biological relevance using pulmonary vascular cells from male and female PH patients in cell-based assays. Preliminary experiments suggest there is incomplete XCI in PH. I propose to combine sequencing and molecular studies to extensively characterize the impact of incomplete XCI on the physiology of male and female PAH cells and identify genes and druggable targets regulating incomplete XCI in PH. Finally, I will explore a novel pulmonary endothelium-specific drug delivery method to deliver identified promising genes/compounds to selectively inhibit the activated pulmonary vasculature thereby minimalizing side effects compared to current delivery methods. Together, this high risk-high gain study will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Customised Nanocomposites Based on Rubber Matrices for High Demand Applications' in the context of a Sixth Framework call.

assistant: **Objectives**

The complexity of including new factors in an already very complex system rubber matrix-carbon black filler-mixing and vulcanisation conditions has caused that recent revolutionary innovations in the plastic industry, such as the use of nano-particles to improve stiffness, strength, abrasion resistance, barrier effect and fire behaviour have not yet been applied in the rubber industry.With this in mind, the project NANORUB intends precisely to develop an industrial technology for the production of nanoclay-based (montmorillonite) rubber composites by the following steps:-Development of a production-exfoliation process for montmorillonite based on organoammonium or phosphonium salts with the organic moiety being as compatible as possible with the rubber matrix.-Surface treatment of the nanoparticles to impede clustering and to promote adhesion with the rubber matrix, using to that purpose peroxydic macroradicals, functionalised liquid rubber and organosilanes.-Optimisation of the formulation, processing and vulcanisation conditions in order to obtain a nanoclay-rubber composite material with at least 3 times better abrasion resistance, 50% improved stiffness, 30% improved strength and 20% delayed ignition with respect to the equivalent reference non-nanoclay reinforced product. Price should not exceed the reference by more than 40%.-Use of the developed materials in the production of prototypes of improved moulded parts, rubber bearings, rubber cords and conveyor belts.The consortium brings together 8 SMEs from 6 countries, namely a nanoparticle producer, a specialty chemicals manufacturer, a mixer-compounder, a machinery constructor and 4 end-users producing moulded parts, rubber bearings, rubber cords and conveyor belts, supported by 4 research organisations in the fie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SEmiconductor disk Lasers for EffiCient Terahertz generation'.

assistant: **Innovation**

The primary goal of this Fellowship, entitled “SEmiconductor disk Lasers for EffiCient Terahertz generation” (SELECT), is totrain a talented researcher through a research project focused on the development of high-performance laser sources basedon semiconductor disk lasers and novel periodically poled ferroelectric and semiconductor crystals that can offer an accessto new wavelengths not covered by available gain media, particularly in the THz spectral region, which are desired for THzspectroscopy, Biomedical imaging, and Safety and Security applications. The novel high-performance vertical-external-cavitysurface-emitting-laser, with remarkable output parameters, will be used as a source of ultra-efficient THz emission in the0.8-3THz spectral window based on difference frequency generation in advanced quasi-phase-matched crystals. Thesuccess of the interdisciplinary project will lead to a number of multidisciplinary disruptive innovations in Photonics withsignificant scientific, technical, economic and social impact, from spectroscopy and biomedical imaging to security screeningand quality control.The Fellow - Dr. Ksenia Fedorova - will be trained in the fast growing field of science, technology and industrial applicationsof semiconductor lasers and THz technology, receiving access to a unique training experience at the host – Philipps-Universität Marburg, and at academic and industrial secondments: Aston University, Innolume GmbH, M-Squared LasersLtd. The project will enable the Fellow to be a rare asset to European research; she will gain a set of multidisciplinaryprofessional skills in both theoretical and practical fields, starting from the laser system design and fabrication and finishingwith implementing the final product into real industrial applications.The SELE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unique Nanocarbons from Critically Opalescent Solutions' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The principal focus of this project is to synthesise carbon nanomaterials and composites with enhanced mechanical and electrical performance using a novel alternative technology. Carbon nanoparticles and polymer composites are formed from the dissociation of critically opalescent fluids via a UV laser. The aim is to produce such materials in a continuous process where the produced material or composite material is synthesised with its final desirable properties in a single to low number of chemistry steps. The project explores the potential of this novel process for the production of new carbon nanomaterials in close collaboration between an academic partner and an SME with the objectives to produce various carbon nanostructures from critically opalescent fluids, to produce carbon nanomaterials with increased electric conductivity, to produce composite materials with improved mechanical properties, to characterise the properties of the produced carbon nanomaterials, to optimise the process conditions and control the resulting structure of the carbon materials, to develop processes suitable for industrial application, to establish new links between academia and SME, to provide access to academic knowledge and infrastructure to industrial partner and vice versa, and to provide staff in industry and academia with transferable skills. The work programme to achieve these goals includes production of novel carbon nanomaterials from carbon dioxide in batch process (specifically carbon nanotubes, carbon nanofibres, carbon platelets, graphene, carbon layers with controlled dielectric properties, and cross-linked polymer composites), construction of a carbon dioxide reactor system for continuous flow process, production of carbon nanomaterials in continuous flow process, analysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interfacing Quantum Optical, Electrical, and Mechanical Systems' (2007-2013).

assistant: **Innovation**

This project aims at the efficient realization of quantum interfaces for high-fidelity conversion and coherent manipulation of quantum states of phonons and of photons at vastly distinct wavelengths. We will consider different experimental platforms, e.g. photonic crystal cavities, nonlinear crystalline resonators, graphene-based nanoelectromechanical systems, and nanomembranes, with the aim of implementing interfaces that are able to interact simultaneously in a tunable way with optical and microwave fields. State transfer and controlled dynamics between radiation modes at completely different frequencies and between photons and phonons will be accomplished using diverse strategies, e.g. by tailoring the coupling of the interface with the fields, by exploiting electromagnetically-induced transparency, or the nonlinearities achievable in the strong coupling regime. The project results will enable new regimes for radio- and microwave electro-magnetic field detection, allowing quantum-limited amplification and readout of microwave and radio-frequency radiation. At the same time solid-state quantum devices which are now mainly manipulated by radiofrequencies and/or microwaves will become efficiently coupled to and controlled by optical fields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dynamic Regulation of photosynthEsis in light-Acclimated organisMs' (DREAM) under Horizon Europe.

assistant: **Objectives**

Cultivation of plants consumes huge resources of water for irrigation and energy for lighting. Introducing disruptive technologies is key to improve plants and enable their parsimonious cultivation.DREAM overtakes these challenges by gathering an interdisciplinary consortium sharing a same radical vision: to measure and exploit the dynamics of photosynthesis regulation under natural-like light conditions for selective sensing – monitoring the plant state – and enhancing lighting efficiency in controlled environments. We develop ground-breaking instruments and acquisition protocols unraveling unprecedented kinetic data from microalgae and plants (including tomato as a crop species) by using novel periodically modulated or randomly fluctuating illuminations, chlorophyll fluorescence, and original luminescent nanosensors. These data are processed with comprehensive theoretical tools (system identification, dynamical systems, system control, machine learning) to build a powerful dynamical model which delivers categorizing fingerprints for highly selective sensing and tailored modulated illuminations for enhancing lighting efficiency. Finally, we implement a server with incremental learning from an open source community to extend sensing to organisms and environmental conditions much beyond the ones used in our DREAM project.DREAM will expand knowledge on photosynthesis regulation and lead to major achievements: categorizing plant states (sensing stresses, selecting improved plants), improving controlled ecosystems (equipping lighting with sensing and decreasing its cost), and instrument design (targeting scientists and many more end-users). DREAM will further improve innovation in key European industries active in the fields of scientific instruments, phenotyping, and plant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Plasmid-Specific Bacteriophages to mitigate the Spread of Antimicrobial Resistance in Used Water & the Environment (Phage POWER).' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Antimicrobial resistance (AMR) is a global public health concern that forebodes a dramatic scenario for the coming decades. This crisis is worsened by the ability of antimicrobial-resistant bacteria to spread their antimicrobial resistance genes (ARGs) between and within microbial communities by horizontal transfer, and especially by conjugation in wastewater environments. Therefore, these environments are hotspots and potential control points in the spread of clinically relevant ARGs. Viruses that attack plasmid-bearing bacteria via plasmid-encoded structures have been described. They were mainly isolated several decades ago where they were instrumental in understanding plasmid biology, but many of them are no longer available and have not been documented comprehensively. It has been demonstrated that they reduce the rate of conjugation in pure culture studies; however, their effect in microbial communities is still unknown. Can we leverage some of these natural ‘enemies’ of plasmids to mitigate the spread of AMR in the diverse microbial communities that are typical of biological water treatment? Can we fight evolution with evolution? This is the ambition of this proposal. The research will be divided into four packages: plasmid collection, phage isolation, phage characterization and phage efficiency assessment. Plasmids involved in the epidemic dissemination of carbapenem and multiple antibiotic resistance will be studied. Phages will fluorescently labelled and used to measure the reduction in transfer rate of ARGs in environmental bacterial communities by fluorescence activated cell sorting. The multidisciplinary nature of the project is strong, involving a combination of environmental microbiology, molecular biology, metagenomics and virology. This innovative approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The use of microwaves for the heating process in the production of ceramic materials' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The drying process is a very important step in the technological cycle for the fabrication of ceramic products. In this project, we wish to concentrate on experimentation and the collection of data to compare microwave drying with conventional methods. Therefore, we are going to construct a prototype microwave system to conduct these tests also to demonstrate the drying of refractories with complex shapes, porcelains, sanitary ware and wall tiles. The possible objectives in summary are: 1. Reduce the lengths of conventional drying cycles. 2. Improve the quality of products and decrease the number of pieces with defects. 3. Reduce the space occupied by the driers. 4. Reduce the material present in the system at any one moment. . 5. Consume a clean energy without combustion products in the factory. 6. Study the energy and economic benefits. 7. Define the characteristics of an optimum microwave system for processing ceramic materials. It is worth emphasising that the experimentation with the demonstrational furnace is of considerable importance of industrial SME'S, the results possibly promoting the installation of innovative and alternative clean technology driers in place of those more traditional.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dissecting the regulation of lateral root formation by phosphate' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Phosphate is an essential nutrient that is present in soils at low concentration with poor mobility and therefore represents a limiting factor for plant growth. The exponential demand of phosphate as a result of world population increase (50% by 2050) could lead to a world shortage of phosphate in a near future. The EmPhos project aims at characterising how plants perceive and adapt their root architecture to low phosphate concentrations. We will dissect and model the auxin regulation of phosphate response using innovative tools (Strand 1) and identify new genes responsible for the increase of lateral root number in response to phosphate starvation (Strand 2). This research will take advantage of tools developped by the applicant during his Marie Curie fellowship and will integrate tools and ressources developped by the host laboratory (Strand 3). This project identifies a collaboration with Prof. Malcolm Bennett (Centre for Plant Integrative Biology, Nottingham, UK) and builds upon the award of a long-term EMBO fellowship (ALTF 503-2010) to the applicant in Dr. Laurent Nussaume's laboratory (Laboratoire de Biologie du Développement des Plantes, CEA Cadarache, France). The outcome of this project will greatly improve our understanding of how plants perceive a low phosphate signal and how this signal is further transduced to generate an architectural response. Therefore, it will shed light on how plants adapt to a changing environment which may lead to application in crop improvement.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Evolution of neuronal cell types, development and circuitry in the insect visual system: breaking down behavioural evolution into its constituent elements'.

assistant: **Concept**

One of the holy grails of neuroscience is to understand how complex behaviours arise. However, surprisingly little is known about how behaviours evolve. My proposal will delve into Behavioural Evolution and Development (BehaEvoDevo) in an unbiased and comprehensive way using the insect visual system as a model. The visual system of Drosophila has been described extensively in terms of cell type composition, development, circuitry, and behaviour. My expertise in this system will be the springboard to address four fundamental questions:  1) How different is the cell type composition in the brains of different animals? 2) How do the mechanisms that are responsible for neuronal development evolve and how do they affect neuronal diversity? 3) What are the differences in the circuitry that underlies specific behaviours in different animals? 4) How do differences in neuronal composition, neuronal features, or circuitry drive different behaviours?  I will combine cutting edge techniques, such as single-cell sequencing, with advanced genetic tools in Drosophila, and adapt innovative tools for genetic manipulation and circuit function in different non-model insects. I will compare how cell type composition, neuronal specification and differentiation, as well as circuitry, affect specific behaviours. I will examine phylogenetically diverse insects to generate a deep understanding of the mechanisms that are most important for the evolution of different behaviours. Moreover, I will identify fundamental principles about how developmental processes, such as neuronal specification and differentiation, evolve to control different behaviours. The cumulative results of this proposal will offer the first comprehensive assessment of the mechanisms that drive evolution of new behaviours acro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SmartFuse: Game-changer to create a new gold-standard for spinal fusion surgery with wirelessly technology' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Spinal surgery has a significant failure rate of 18% leading to devastating complications for patients. With the knowledge that bone remodels naturally using electric signals, we are transferring cutting edge neuromodulation technology into the orthopaedic field. We incorporate our proprietary, wirelessly powered bio-electrical stimulation system into standard orthopaedic implants. Our first product, SmartFuse, addresses the issues of non-union and bone overgrowth in spinal fusion surgery by harnessing the local delivery of electrical stimulation to accelerate bone growth and control the formation of new bone. In addition to accelerating and controlling bone growth, SmartFuse can measure the quantity and quality of new bone, enabling real-time feedback on the progress of healing to the physician and other caregivers. Through EIC funding, we will complete a clinical pilot trial, and prepare a pivotal study demonstrating efficiency and safety to achieve the necessary market approvals.


**Keywords:** electro-therapeutics,bioelectronics,fusion rate,electrical stimulation,fracture repair,bone implants,bone growth,bone fusion,spinal fusion