RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Novel nanosized GDNF mimetics for the treatment of Parkinson’s disease: focus onto non-dopaminergic features'.

assistant: **Concept**

PD is the most common age-related neurodegenerative disorder that is characterized by four pathognomonic hallmarks: 1) motor and non-motor deficits; 2) progressive loss of nigrostriatal dopamine neurons; 3) pathological aggregates of the α-synuclein (α-syn) protein; 4) neuroinflammation and oxidative stress. There is no single treatment currently available (or being tested) that can affect mechanisms of the disease, promote regeneration or at least protection of dopamine (and other affected neurons), and alleviate both motor and non-motor symptoms. Importantly, non-motor symptoms severely alter the quality of life of the patients since they are even more debilitating than the motor ones and do not respond to dopaminergic-based therapies. One of the therapeutically potent approaches to combat PD is neurotrophic factors (NTFs)-based therapies, particularly the glial cell line-derived neurotrophic factor (GDNF). GDNF demonstrated encouraging survival-promoting effects on dopamine neurons in diverse PD animal models and held a great hope as a neuroprotective treatment. Also, GDNF has positive impact in a number of other neurons such as sensory, enteric, olfactory, etc., which degeneration or dysfunction is associated with the appearance of non-motor symptoms. Despite of the promising results, GDNF due to poor tissue distribution and inability to pass through the blood brain barrier should be delivered to the brain through a risky surgery. To overcome the delivery problems and finally utilize the potential of GDNF in PD management proposed project combines neurobiology, translational biology, and experimental pharmacology to develop nanosized GDNF mimetic-based drug candidate that will 1) positively impact the disease progression through mitigation of the pathogenesis associ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European consortium of earthquake shaking tables - phase 2' (ECOEST).

assistant: **Concept**

This proposal is for a 4-year extension of the Bristol Part of the successful ECOEST programme funded (1900 kECU) by the Commission within HCMP (Large facilities) for the period 1.3.9329.2.96. ECOEST contains four of Europe's principal earthquake engineering laboratories, at Athens, Bergamo, Bristol (co-ordinator) and Lisbon. ECOEST2 proposes the addition of Julich (Germany) to this quartet*. Recent earthquakes in California (1994 and Japan (1995) have confirmed the timeliness and value of the ECOEST research programme, particularly the need to mobilise total European competence if satisfactory results are to be obtained in reasonable time. Bristol contributes significantly to the five main research themes of ECOEST, which are: 1 To standardise shaking table facilities and operating procedures at international levels, allowing Europe-wide research activity. 2 To give specific support to research requirements of EUROCODE8 (Design of Structures in Seismic Areas) in all topics specified by the drafting committee . 3 To accept European researchers to participate in Bristol's own research in steel structures, long-span bridges and dams. 4 To offer training in the use of shaking tables in seismic design and to promote good practice. 5 To publish research results and data in support of the European Construction Industry in its internationally competitive activities. After this proposal had been prepared (5.4.95) Julich decided to wait until the 2nd call for proposals (March 1997) before joining ECOEST 2.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Statistical Machine Learning for Dynamic Network Modelling' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Networks are ubiquitous in the society, technology, biology and economy. Being able to perform accurate inference and prediction on such data is highly non-trivial due to their large size and complex dynamic behaviour. In many networks such as social ones, connectivity patterns and network structurechange dynamically. On the other hand, technological networks such as water systems have fixed structure but dynamic processes might take place on them appear, such as failures. DyNeMo is a cross-disciplinary project that aims to provide a novel, explainable yet scalable framework using statistical machine learning to model dynamic behavior on networks, with the goal to answer crucial scientific questions with social and environmental impact, influencing public policy. The project combines statistical tools that ensure flexibility, data adaptivity and interpretable parameters with Deep Learning tools ensuring efficiency and scalability. The methods will be used to answer two highly impactful scientific questions given access on unique datasets. The first is how companies worldwide can maximize their socio-environmental impact aligned with UN sustainable goal strategies. The second question is how to quantify and predict behaviour of cascading pipe failures on the water distribution systems in Cyprus. The results will detect patterns and perform prediction, thus influencing public policy in alignment to the EU strategic goals on monitoring water systems. The fellow and the supervisor have complementary expertise which in combination with the plan, the arrangements and environment provided by the host institution ensure a successful implementation of this novel and timely project as well as an effective dissemination and utilisation of the expected outcomes. The results of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a Microfluidic Microbial Ecology Device and Mathematical Model to Study Antibiotic Response of Individual Cells' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

To discover effective strategies against antimicrobial resistance, a deeper understanding of microbial behaviour in their natural ecologies is crucial. The essential technological bottleneck that has limited our capability to explore this issue is the microenvironment provided by batch culture assays. They are incapable of mimicking natural microhabitats, quantifying individual bacteria, and revealing antibiotic resistance. Therefore, development of a theoretical and experimental framework that mimics the natural microecology of bacteria and measuring their antibiotic response to predict optimum survival strategies will provide valuable tools to investigate bacterial individuality and their changing response to antibiotics in realistic microenvironments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding and fighting metastasis via dissection of the Core Invasive Machinery' in the context of a Seventh Framework call.

assistant: **Objectives**

The co-operative Metafight project will perform functional studies to understand the dissemination and outgrowth of metastasis through systematic analysis of the Core Invasive Machinery contained within integrin-mediated ECM attachment structure. It includes a large and discretely localised intracellular signalling network which drives migration and invasion. Our strategy is based on the hypothesis that metastatic cells arise from molecular changes that alter the primary tumour architecture as well as the tumor microenvironment, by reversible modulation of cell adhesion, onset of signalling pathways and acquisition of novel migratory and invasive capacities. The Metafight Consortium is strengthened by established combined expertise on adhesion receptor signalling and availability of unique tumor cell and cancer animal model systems. We will characterise known and novel components of the Core Invasive Machinery, responsible for development and homing of metastasis, by innovative in vivo non-invasive imaging techniques. The Metafight project comprises seven major interrelated Work Packages (WP). WP1 is designed to investigate the molecular and functional architecture of the Core Invasive Machinery, from which depends tumour cell migration and eventually invasion. WP2 and WP3 screen for key modulators of metastasis formation in in vivo murine models, by non-invasive imaging techniques. WP4 is related to a comprehensive proteomic analysis of expression and phosphorylation of our candidate modulators in metastasis formation. WP1-4 feed into WP5, which builds upon and exploits knowledge generated in the first four WPs and translates it into existing pharmacological interventions to generate new candidate drugs. This will lead to patent filing and licensing strategies. WP6 and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative strategies to increase engraftment of engineered hematopoietic stem cells and bypass genotoxic conditioning, toward the next-generation gene therapy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) refers to the transfer of nucleic acids into HSPCs, to either add a new copy of a “healthy” gene or to correct a mutated gene. HSPC-GT is successfully used in clinic to treat patients with hematopoietic malignancies and several inherited diseases of the hematopoietic system. Yet, its current use is accompanied by acute conditioning-related toxicities, which impose a burden on patients and limit its application to the most severe conditions. HSPC-GT requires the following steps: HSPCs are mobilized and harvested from the patient, genetically corrected ex-vivo by gene transfer or gene editing and infused back to the patient, after administration of partial or fully myeloablative conditioning to make space in the bone marrow for the modified cells. Administered HSPCs home to the bone marrow, where they engraft and reconstitute a healthy immune system, theoretically throughout life. However, two major shortcomings undermine the full therapeutic potential of HSPC-GT: (i) a decrease in short- and/or long-term engraftment potential due to the ex vivo manipulation of HSPCs and (ii) a toxicity in the hematopoietic and non-hematopoietic organs related to the conditioning regimens, which are based on cytotoxic drugs. The project IMPROVING-GT proposes to develop innovative schemes to increase engraftment and dodge genotoxic conditioning, which are some of the most coveted but still unaccomplished goals of HSPC-GT. The candidate aims to (1) increase the fitness of genetically modified HSPCs by uncovering new players of engraftment and (2) bypass the toxic conditioning requirement by exploiting enhanced mobilization reagents. IMPROVING-GT will pave the way towards non or milder genotoxic regimens, which should greatly minimize
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cultural Opposition: Understanding the Cultural Heritage of Dissent in the Former Socialist Countries' in the context of a Horizon 2020 call.

assistant: **Objectives**

The project proposes both to create an electronic registry of representative online and offline, private and public collections of cultural opposition in all former socialist countries in Europe and to study the origins, uses and changing roles of these collections in their social, political and cultural contexts. We seek to further an understanding of how these (private and public, alternative and mainstream) collections work, what functions they serve in their respective societies, and how they represent their holdings to the public. The project will examine the legal and political circumstances that determined the collections before 1989 and the conditions that shape them in the post-socialist period. The analyses of the collections will identify various types of cultural opposition.Objectives include: 1. an online registry and a transnational database of collections in the original languages and English that will be accessible to European archival platforms and networks; 2. descriptions of and guides to the collections to enhance the quality of research and provide guidance on the role of the EU in this respect; 3. country reports on the collections and proposals concerning methods of preserving cultural heritage, and a handbook on various types of cultural opposition represented by the collections; 4. online curriculum development and digital content for educational purposes; 5. a documentary film festival, traveling and online exhibitions and local media events based on selected collections; 6. a set of recommendations concerning how to exhibit the cultural opposition movements of former socialist countries for the House of European History.This project will highlight the positive aspects of the former cultural opposition movements, such as democratic participatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From receptor to gene: structures of complexes from signalling pathways linking immunology, neurobiology and cancer' (SPINE2-COMPLEXES), addressing dissemination and exploitation.

assistant: **Impact**

SPINE2-COMPLEXES (S2C) builds on SPINE successes (in establishing infrastructure and activity in HTP structural biology across Europe) to attack two of the central objectives of Structural Biology. Firstly, S2C will focus on systems of demonstrated biomedical relevance, almost entirely human proteins (plus some viral mimics). Secondly it will address the functional form of these proteins, complexes, interlinked in human signalling pathways of importance for human health. The S2C team is built upon a core of SPINE laboratories, selected on the basis of their enthusiasm to sign up to the concept of sharing work and pooling protein reagents within the Partnership to accelerate progress through cooperation. The new Partners include excellent young group leaders from the New Member States. Despite dramatic technological advances in HTP protein production there is an urgent need to develop specific technologies appropriate to S2C not covered by other FP6 grants (eg synchrotron technology is largely addressed by BIOXHIT).  Major technology developments will therefore be in protein production, especially HTP methods for eukaryotic expression, including co-expression, through refolding, to library based methods. The human signaling pathways targeted are  i) ubiquitination and de-ubiquitination  ii) cell cycle and apoptosis  iii) synaptogenesis and neuronal signalling  iv) kinases and phosphatases involved in signalling and regulation  v) transcriptional receptors and regulation  vi) innate and acquired immune receptors and inflammation and vii) viral subversion of cellular signalling and immune modulation.  These cellular processes frequently involve the same components and pathways, enhancing opportunities for inter-partner synergies. All Partners have signed up to joint target
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Microscopic modelling of the highly efficient intra- and inter-antennae energy transfer to the reaction centre in plant photosystem II'.

assistant: **Objectives**

MicroMod-PSII aims to provide an unprecedented microscopic, structure-based understanding of the excitation energy transfer mechanism in plant photosystem II (PSII) from the outer antennae complexes to the reaction centre under physiological conditions. It will unravel nature’s highly sophisticated way of harvesting sunlight in unrivalled detail.Within the framework of MicroMod-PSII, the first-ever coarse grained molecular dynamics simulations at almost atomistic resolution of PSII supercomplexes in thylakoid membrane patches will be performed. Based thereon, the intra- and inter-antennae excitation energy transfer toward the reaction centre will be modelled using high-level ab initio quantum chemistry. For this purpose, a procedure will be developed to transform coarse grained molecular dynamics snapshots into atomistic structures best suited for quantum chemical calculations. The calculated chromophore properties will provide a detailed understanding of the interplay between rigorous, highly conserved structural organisation and dynamic flexibility at the protein-protein interfaces and its impact on the outstanding light harvesting properties of PSII. The overall strategy developed during MicroMod-PSII can emerge as an important tool for computational biology as it allows modelling of a wide variety of reactions in the electronic ground or excited state catalysed by protein supercomplexes.During MicroMod-PSII, the researcher will acquire extensive expertise in state-of-the-art coarse grain molecular dynamics and will transfer knowledge in quantum chemistry and quantum dynamics to the host group. The improvement of complementary skills such as scientific management, networking, public engagement and team leadership will significantly develop the researcher. Together wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'INK-BASED HYBRID MULTI-MATERIAL FABRICATION OF NEXT GENERATION IMPLANTS'.

assistant: **Innovation**

Improving the life quality of Europe’s increasingly elderly population is one of the most pressing challenges our society faces today. The need to treat age-related degenerative changes in e.g. articular joints or dental implants will boost the market opportunities for tissue regeneration products like biological scaffolds. State of the art 3D printing technologies can provide biocompatible implants with the right macroscopic shape to fit a patient-specific tissue defect. However, for a real functionality, there is a need for new biomaterials, technologies and processes that additionally allow the fabrication of a scaffold microstructure that induces tissue-specific regeneration. It is not possible to address the complexity in structure and properties of human tissues with a single material or fabrication technique. Besides, there are many types of tissue in the human body, each with their own internal structures and functions. INKplant vision is the fusion/combination of different biomaterials (6 different inks), high-resolution, high throughput additive manufacturing technologies already proved for industrial processes (ceramic sterolithography and 3D multimaterial inkjet printing), and advanced simulation and biological evaluation, to bring a new concept for the design and fabrication of biomimetic scaffolds (3D printed patient specific resorbable cell-free implants) which can address the complexity of the different tissue in the human body, demonstrated for 2 Use Cases. For a successful future translation, INKplant will consider all the relevant clinical adoption criteria already at the beginning of the development process. To address INKplant challenging objective the consortium includes the best expertise from the main areas of relevance to the project: biomateria