RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Organization of the Conference EURONANOFORUM 2007 - Nanotechnology in Industrial Applications' (2002-2006).

assistant: **Concept**

Nanotechnology is one of the most promising cross-section technologies and can be understood as an important key technology of the 21 century. It helps to improve products and production processes with better characteristics or new functionalities. In the upcoming years nanotechnology will impact nearly all industrial sectors and enter consumer markets in large quantities. The intended EuroNanoForum 2007 will be organized as a 3- day conference, taking place from June 19 to 21, 2007 at the Conference Center Duesseldorf within the German presidency. The conference will be established as the foremost European congress for the transfer of nanotechnology from research into industrial production processes, products and applications. It brings together excellent scientists with leading researchers and managers from industry. The comprehensive conference programme will present the current state of nanotechnology for industrial applications and open up new perspectives for Europe in the coming years. The conference is focused on Nanotechnology in industrial applications and will contribute to:- A successful development of European nanotechnology through the exchange of knowledge between participants from all European countries with representatives from industry, research, finance;- Finding ideas to transform the results of nanotechnology research into new products and profit for European industry;- Show the state of the art of European nanotechnology products and components for different applicationsBesides the sessions an accompanying poster exhibition and an industrial exhibition is planned. The accompanying industrial exhibition shall demonstrate the state of the art of industrial implementation of technical knowledge into industrial products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bayesian Biometrics For Forensics' (BBFOR2).

assistant: **Concept**

With various forms of biometric technologies becoming available, there is a growing need for scientists who are able to assess the merits of these technologies when applied to forensics. The Marie Curie ITN `Bayesian Biometrics for Forensics,' or BBfor2, will provide a training infrastructure that will educate Early Stage Researchers in the core biometric technologies of speaker, face and fingerprint recognition, as well as the forensic aspects of these technologies. According to modern interpretation of evidence in court, biometric evidence must be presented as likelihood ratios. The calibration of likelihood ratios of individual behavioural and physical biometrics and of combinations of biometric modalities, including measures of the quality of the traces, is a unifying topic in all research projects in this Network. The training of ESRs will be realized as individual PhD projects at various research labs, including a forensic institute. Apart from training at their host institute and secondments with other network partners, the ESRs will receive training in dedicated Summer Schools on Biometric Signal Processing, Bayesian Techniques in Forensic Applications and Legal Issues in Forensic Applications. The Network combines 8 European Universities and a leading Forensic Institute; it is augmented by a biometric industrial and a research institute, where secondments of the ESRs will take place.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploiting the Potential of Structural Biology through NMR and Associated Technologies - Opportunities for Economic Development of Pharma/Biotech in Tuscany, Berlin-Brandenburg and Beyond' (EPISODE) under Seventh Framework.

assistant: **Objectives**

EPISODE’s goal is to maximize the regional benefits of Structural Biology Research Infrastructures in NMR and associated technologies for the economic development of the pharma/biotech industries in Tuscany, Berlin-Brandenburg and beyond.  As traditional Structural Biology research moves towards new horizons, a major goal has become a systemic view of Life, implying a change of focus from single molecules and interactions to an integrated view of networks of interactions at varying levels of biological organization.  NMR and associated technologies are an integral part of such research, and their importance has recently been reflected in the ESFRI Roadmap’s INSTRUCT Integrated Structural Biology Infrastructure.  While this emerging paradigm presents myriad new opportunities for the R&D programs of the pharma/biotech sectors, the technologies and their associated research infrastructures have not yet been fully exploited, a situation that must urgently be understood and rectified.  Berlin-Brandenburg and Tuscany are uniquely poised to meet this challenge, in part through the presence of strong research infrastructures.  EPISODE will encourage cooperation and collaboration among regional research institutions, business and areas agencies to couple research with revenue, through the following actions: (i) research-driven clusters will be expanded and stimulated interregionally and transnationally; (ii) current regional capabilities in terms of research potential and exploitation will be studied; (iii) a Joint Action Plan will be developed to define how to drive future economic development.  Dissemination and outreach efforts, the encouragement of collaborations, support measures for SMEs and spin-offs, and the mentoring of less-developed regions will be given a special pla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Applying Java to Automotive Control Systems' (AJACS).

assistant: **Concept**

AJACS will specify, develop and demonstrate an open technology allowing the use of Java in deeply embedded automotive electronic control units such as engine control systems. Existing work on small foot-print Java platforms and on real-time Java will be included in OSEK/VDX (Open Systems and the corresponding interfaces for automotive electronics/Vehicle Distributed eXecutive) technology. Native code approach will be investigated. Two automotive control units will be developed for validation. The resulting technology specification will be promoted in the OSEK/VDX and Java community for standardization.OBJECTIVESThe objective of AJACS is to specify, develop and demonstrate and open technology allowing the use of Java in deeply embedded automotive electronic control units (ECU) such as engine control systems. From an industrial viewpoint, the objective is to have an open technology which - relies on existing standards of the automotive industry, in particular OSEK/VDX - fully retains the benefits expected from object oriented language programming in terms of software structuring, reusability, dependability - full retains the WORA (Write Once Run Anywhere) attribute associated with Java - supports the same kind of real-time constraints which today Java based ECU are managing today - targets the type of electronic configurations that are in use in the industry: 16 tit microcontrollers and memory footprint ranging from 64 Kbyte to several hundred Kbytes ROM for the whole system.DESCRIPTION OF WORKAJACS will specify mechanisms and APIs which in particular - supports automotive control systems typical standards (e.g. coexistence with OSEK/VDX based applications written in C) - conforms to future Java deeply embedded standards and Java real-time standards - address automotive c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'YAK kinase regulated trypanosome quorum sensing' (TRYP-QS).

assistant: **Innovation**

African trypanosomes are parasites that cause disease in both humans and livestock throughout sub Saharan Africa, leading to death and hardship in afflicted regions. The disease is spread by blood-feeding tsetse flies and trypanosomes use sophisticated mechanisms to sense their environment in order to optimise their chances of transmission. In particular, whilst in the host bloodstream trypanosomes communicate with one another to monitor their own population density, this determining when they produce specialised transmission stages (so called ‘Stumpy’ forms).  We have recently identified, using a genome-wide RNAi screen, components of the signal transduction pathway that drive this quorum sensing (QS) response. One component seems pivotal in the pathway- a molecule related to the YAK kinase of proteins. In yeasts and slime molds YAK kinase contributes to cell growth arrest in response to extracellular signals including nutrient limitation, whilst in mammals, related molecules of the DYRK family can also act in cellular quiescence. In this proposal we will investigate the function of trypanosome YAK kinase in the parasite's QS response. Specifically, we will investigate the kinase function in vitro and in vivo and dissect its action by following its location and targets. These are likely to differ from the situation in yeasts where YAK relocates to the nucleus and changes mRNA expression; in trypanosomes gene regulation is almost exclusively post transcriptional and likely operates within the cytoplasm. The function, location and interactions of YAK kinase in the QS signalling pathway is expected to provide comprehensive insight into how trypanosome parasites control their development in preparation for transmission, with additional important relevance for related paras
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'On-demand COMmunication between fluorescent organic nanoparticles through Energy Transfer' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In situ and real-time detection of analytes in complex biological media requires the development of robust and sensitive biosensors. In this context, the interdisciplinary COMET project will develop innovative optical biosensors based on communicating nanoparticles (NPs) whose response is modulated by the presence of opioids.To date, robust inter-particle communication between optically-active NPs has only been described with inorganics, involving either electron or resonance energy transfer. Despite their excellent optical properties, inorganic NPs raise environmental and biocompatibility concerns with respect to their toxicity or colloidal stability. In that regard, Fluorescent Organic Nanoparticles (FONs) are an interesting alternative: FONs are composed of organic dyes condensed in a small volume and engineered to display intense absorption and excellent brightness. The optimal arrangement of spectrally complementary FONs acting as synergistic energy donors and acceptors will address the critical challenge of achieving communication between NPs and signal amplification.To meet this goal, COMET will reinvent the classical FONs elaboration by investigating the self-assembly of dedicated dyes concomitantly with a biological recognition moiety in water. Spectrally relevant FONs will be associated into nano-constructions in which a donor and an acceptor FON are brought together to enable energy transfer. I will then design stimuli-responsive biosensors based on the triggered disruption of these nano-assemblies by an analyte, particularly opioids. The detection of nanomolar traces of opioids will be achieved thanks to signal amplification through cascade energy transfers within and between FONs.Such communicating nano-tools will provide the next generation of continuous r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'white room based on Reconfigurable robotic Island for optoelectronics'.

assistant: **Concept**

The young optoelectronic industry has critical mass and already impacts for more than the 10% on the European economy, employing 290 000 people and guarantees a stable double digit growth in current and coming years. Europe is playing a leading role in R&D (>1,000 research organization active) and is still able to face Far East and American competitors in manufacturing. white’R is a necessary action to translate this R&D excellence into future leadership in manufacturing high value added optoelectronic devices. white’R production island aims to make a move away from the manual assembly processes that have characterized the industry for decades to high-accuracy, high-yield, automated methods.The new manufacturing concept is based on the combination of fully automated, self contained, “white room” modules whose components - robots, end effectors, transport, handling and tooling systems - are conceived as “Plug&Produce” mechatronic sub-modules properly configured coherently with the production requirements. The technical objectives of white’R system are: 50% reduction of cost compared to current productions system; 30% set-up and ramp-up time reduction by self adaptive reconfigurability; All components of the production system reusable re-assembled and upgraded in a new different system; Creation of a EU/International standard for optoelectronic package configuration.The achievement of the objectives will be demonstrated by 2 different demonstrators where the same white’R island will be reconfigured to be used in two different real industrial environments related to the laser processing (Prima Power) and the solar energy systems (NSL). white’R team forms a lean and efficient organization linking together 3 academic and research institutions  to 10 industrial partners from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploring the Universe through Strong Interactions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The ERC project EUSTRONG will enable major breakthroughs in understanding strong interactions in nuclei and neutron stars, and where strong interactions are essential in dark matter direct detection and neutrino physics. Recently, great progress has been made in constraining the nuclear equation of state from nuclear physics combined with neutron star observations and the neutron star merger GW170817. At the same time, ab initio calculations of nuclei using chiral effective field theory (EFT) interactions have reached nuclei with up to 100 nucleons. These successes are based in parts on developments in my past ERC Starting Grant. Taking these to the next level, we will explore the equation of state with the goal to provide first constraints directly on dense matter interactions from astrophysics, including from new NASA NICER observations. This will enable us to answer which microscopic interactions are consistent with astrophysical observations, or where there are tensions. To this end, we will develop the equation of state to high densities using Fermi liquid theory, and explore new degrees of freedom at intermediate densities. The second work package will advance the ab initio frontier to key heavy nuclei including full uncertainty quantification. This will be realized by developing eigenvector continuation and tensor network methods to the ab initio in-medium similarity renormalization group. Another milestone will explore EFTs and novel power countings for nuclei. This will open new horizons in the physics of nuclei, with global ab initio predictions of nuclear masses for r-process simulations. The third work package will derive ab initio nuclear responses for dark matter direct detection and coherent neutrino scattering, where a reliable understanding of strong in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Randomised Controlled Trial of Preventive Treatment of Latent Tuberculosis Infection in Patients with Diabetes Mellitus'.

assistant: **Innovation**

Diabetes Mellitus (DM) contributes to an estimated 11.3% of adult deaths worldwide. Approximately 1 in 10 adults globally are estimated to have DM and the prevalence will rise significantly over the coming decades, especially in sub-Saharan Africa. People with DM have a three-fold increased risk of developing TB, and two-fold higher risk of dying from TB or experiencing treatment failure or recurrent disease, further threatening global TB control. As such, the growing burden of DM alongside the continuing TB epidemic have huge health and socio- economic impact. PROTID performs the first randomized controlled trial (RCT) globally to evaluate efficacy, safety, cost-utility and population impact of preventive treatment of TB preventive therapy for people with DM. It also examines gaps in diagnosis and management of DM and DM-TB in Uganda and Tanzania. Our results will guide global policy on TB prevention and management in people with DM, and this can have large socio-economic impact. In Africa, this is highly relevant given the double burden of DM and TB. In Europe, our results will be highly relevant for migrants and people living in eastern Europe, as both groups have a high burden of DM, latent tuberculosis infection (LTBI) and TB disease. PROTIDs results so far, and other advancements in the field, have already set clear research priorities beyond PROTID. PROTID is very well-positioned to take these forward, with strengthened leadership and research capacity in PROTIDs African partners embedded in a global research network, and its accumulated data on the largest and most-well characterized longitudinal cohort on DM and TB globally.


**Keywords:** tuberculosis,  drugs,  diabetes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A novel and revolutionary instrument for the classification and sizing of micro-” and nano- particles in biological, industrial and environmental complex fluids.'.

assistant: **Innovation**

A vast number of industries rely on particle size as a critical process and it stands as a crucial step for the manufacturing of several products such inks, cement, pharmaceuticals, make-up, fertilisers. Particle size is thus a key factor in several - and more and more increasing - industrial sectors and development/manufacturing proceedings such as crushing, homogenization, emulsification, microfluidization when lab measurements are needed to track changes in particle size,  and particle stability. The increasing nanotechnology research, the presence of stringent regulatory guidelines to ensure compliance with GMP guidelines are driving the growth of the global particle size analysis market, which is projected to reach USD 256.1 M by 2021, at CAGR of 4.7% from 2016 to 2021. To take advantage of this large business opportunity, we developed ClassizerTM, a particle size analyser built upon our revolutionary patented Single Particle Extinction & Scattering (SPES) for the characterization of micro and nanoparticles or corpuscles suspended in fluids, which enables a cheaper, faster, more reliable and informative characterization in biological, industrial and environmental complex fluids. ClassizerTM outperforms the present alternatives onto the market with respect to the actual instrumentation as it can provide information that are usually foreclosed to traditional technologies, such as distinguishing different compositions of particles in complex fluids, determining the true size distribution of the particles, retrieve information about the shape/aspect ratio of the particles and controlling the presence of aggregates and/or contaminants. This will result in boosting R&D and QC processes during lab scale or industrial production of micro and nanoparticles, while the analys