RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Development of molecular probes for the non-invasive detection of liver fibrosis'.

assistant: **Concept**

Liver fibrosis is a progressive and fatal disease characterized by the accumulation of excessive amounts of scar tissue in response to chronic liver injury. The disease proceeds asymptomatically, until clinical signs of liver failure occur only in a very late stage of the disease. Early diagnosis would offer better treatment options. However, early detection and quantification of fibrosis, as well as determining the rate of fibrosis progression (fibrogenesis) or reversal (fibrolysis) still depends on rudimentary and inaccurate methods. This proposal focuses on the development of a new method for the quantification of liver fibrosis and its dynamics, based on the design of molecular probes that can selectively pinpoint these processes in non-invasive imaging studies. To this end, novel disease markers of fibrosis, fibrogenesis and fibrolysis will be identified using state-of-the-art proteomic techniques, simultaneously taking into account that these markers will have to be easily accessible for intravenously-injected ligands in vivo. Based on the identified markers, binding probes will be synthesized and evaluated for their detection capabilities in fibrosis models. To this end, whole body imaging studies are used, combined with novel pharmacokinetic-modeling approaches, in which body distribution, cellular uptake and excretion of the new probes are correlated to disease parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Physics of Sea-level rise Contribution to Shoreline Erosion' (PhySeaCS).

assistant: **Concept**

Global warming and accelerating mean sea-level rise (SLR) arise the critical need for long-term (multi-decadal) shoreline projections to inform coastal adaptation plans. Currently, interactions among SLR and other processes driving shoreline change are poorly understood, and estimating the effects of SLR on long-term shoreline behaviour remains an open  challenge. To fill this knowledge gap, this project will provide new physical insights on the combined effects of waves and SLR on sandy beaches, and develop an equilibrium-based approach for SLR-driven shoreline change. Shoreline data extracted from physical models, satellite imagery and topographic surveys at a variety of sites worldwide, allow building an unprecedented dataset of multi-decadal time series of shoreline positions. Such time series will be analysed to investigate the relations among shoreline change and its primary drivers (waves and SLR), and to validate the developed approach at a variety of selected sites worldwide. This study will characterize the role of waves in shoreline response to SLR, and provide a physics-based approach for more reliable assessment of long-term shoreline projections including the effects of SLR.


**Keywords:** sea-level rise, shoreline modelling, coastal erosion, climate change adaptation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Electronic Communications Legal Expertise Transfer' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Electronic Communications Legal Expertise Transfer (ECLET) will aim at advancing new areas of the host organization's competence in the field of law regarding a wide range of aspects of electronic communication (content, conveyance, processing) as well as its economic background and impact on policy, and finally, on the society. An entity focusing exclusively on these topics - Research Centre for Legal and Economic Issues of Electronic Communication (CBKE) was established by the host organization in June 2002, therefore the said areas should be deemed new to the unit. However, since its formation CBKE has organized the international conference (called 'Legal Framework for Information Society' - September 2002), and another one is being held in June 2003 ('Application of means of electronic communication in the judiciary'). It has hosted foreign scientists for their individual lectures and seminars, has established an Internet portal and an electronic journal. At present CBKE is preparing both a handbook and regular courses for law students in the field covered by the project. Bearing that in mind, the project will develop the current research capabilities of the host organization. The capabilities cannot be developed by the domestic resources, as the host organization is already recognized nationally as a leading one in the field covered by the project. Now, achievement of the highest European level of excellence is the host organization's priority. The ECLET shall let it achieve the goal. On the other hand, the methodology used in the knowledge transfer will not be focused on mere acquiring the knowledge by the host organization, but on its further dissemination to other research centres and to rule making bodies. The project will also contribute to the whole range of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Targeting Brain Inflammation For Improved Functional Recovery in Acute Neurodegenerative Disorders', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In acute neurodegenerative disorders, following a sudden insult, neurons are rapidly damaged and usually die but cellular loss can occur hours and days thereafter. These diseases cause massive morbidity and mortality and tremendous economic and societal burden, especially ischemic stroke, which is a leading cause of death and disability with no effective treatment to promote recovery. The brain responds to a stroke, i.e., occlusion of a cerebral artery, with an inflammatory process characterized by rapid activation of resident cells including microglia and astrocytes, production of proinflammatory mediators, and infiltration of various types of immune cells. Recent studies have suggested that the local inflammation is not only detrimental but can also be beneficial for the repair process. Our proposal unites 7 leading academic teams and 2 experienced SMEs and aims to develop a pre-clinical protocol for immunomodulation leading to enhancement of cellular plasticity and improved functional recovery in stroke patients. To achieve this goal we will study the temporal and spatial role of inflammatory cells in stroke-induced brain damage and determine the action of inflammatory cells in the activation and support of regenerative processes, including the formation of new neurons from endogenous and transplanted neural stem cells (NSCs). We will investigate the ability of transplanted NSCs to modulate the inflammatory response and to affect the characteristics of the stroke-induced lesion and subsequent recovery. The overriding social objective of our project is to develop a novel therapeutic strategy which will shorten the recovery phase, minimize the motor impairments, and improve the patients’quality of life after stroke.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development and validation of an european standardised outcome instrument for patient evaluation of the quality of care in general practice' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This project aims at improving the sensitiveness of primary health care providers in Europe to patients needs and demands. This is achieved by developing an internationally standardised outcome instrument for measuring patient evaluations of the quality of general practice care. This instrument is needed for making international comparisons to identify quality problems related to different health care systems and primary care delivery.A Task Force with participants from 7 European countries is involved in the development of this instrument since 1993. This project will contribute to the quality of life and satisfaction of patients in primary health care in Europe. The insights provided by the study can be used for education and training of health care professionals in order to improve their responsiveness to patients needs and demands. In addition, using the insights health care system reforms can be guided and scarce resources can be applied more effectively and more efficiently.The project comprises three interrelated parts:(1) A priorities study (month 1-8), in which patients needs and demands concerning general practice care are documented and compared, and indicators for the quality of general practice care are selected that reflect patients priorities.(2) A validation study (month 9-20), in which an internationally standardised instrument for patient evaluations of general practice care is developed, using the indicators selected in the priorities study.(3) An international comparison study (month 21-36), in which the standardised instrument for patient evaluations concerning general practice care is applied in different European countries and quality problems related to specific aspects of health care systems and primary care delivery are identified. To support t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Measurement system aiming to improve the comfort of people fitted with prostheses or ortheses' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Between 800,000 and 1 million Europeans are fitted with prostheses or ortheses as a result of congenital deformities, growth problems and especially accidents. For these Europeans, the question of the daily comfort given by their device is essential. This comfort is optimal when an adjustment of the fitting allows an even spread of perpendicular and shearing pressures between the skin and the socket and / or the corset. Today, there is no technology allowing the measurement of shearing forces so the adjustment is subjective and depends on the skill of the orthoprosthetist. The fight against pain experienced by those fitted with devices is therefore difficult. There follows, in an advanced phase, pathologies of sores that are handicapping and carry a high cost both individually and socially. The objective of our research project is to define the characteristics of a measurement system, by the use of pressure sensors, at the interface between the prosthesis/orthesis and the skin. This innovative system will reduce the risk of sores by half, improve comfort in an object way, reduce the number of X-ray checkups and will be an evaluatory tool of orthopaedic fittings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Waves of history in the South Pacific: A gene-culture coevolutionary approach'.

assistant: **Concept**

Modern humans have colonized every possible ecological niche, with the latest expansions being those into the remote islands of the South Pacific. This success has been underpinned both by genetic adaptations to new ecological conditions and by an ever-accumulating store of technological and cultural knowledge gained through social learning. Our dual inheritance systems of genetics and culture interact in unique and unexpected ways, making human history vastly more difficult to infer than for any other species. The emerging field of gene-culture coevolution promises to provide a cohesive framework for modeling the interplay of genes and culture, and will revolutionize our understanding of human historical processes. The Waves project will build the tools necessary to establish gene-culture coevolution in the genomic-era, extending cutting-edge population genetic techniques – including spatial simulation – and allowing the natural integration of data from across genomics, archaeogenetics, archaeology and historical linguistics. We will focus on the South Pacific, a region whose past demography remains largely unresolved. While the population history of this region is relatively short it appears extremely complex, comprising not only multiple waves of colonization but also the existence of wide and ongoing interaction spheres through which both seafaring peoples and their cultures maintained long-distance connections. By generating comprehensive new ancient and present-day genome-wide datasets across Near and Remote Oceania – and analyzing them alongside historical linguistic and cultural data – the Waves project will create the first unified gene-culture coevolutionary history of the South Pacific.


**Keywords:** Gene-culture coevolution, demographic history
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Schelling’s philosophy of nature and the environmental challenge' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The contemporary environmental crisis has triggered a revival of discussions on the concept of nature. Among scientists, philosophers, policy makers and citizens questions regarding environmental practices and the overall state of nature have become a matter of central concern. But what exactly is nature beyond the specific phenomena studied by specialized natural sciences, such as physics, chemistry or biology? Is there something else beyond these particular phenomena? What is the relationship between these phenomena and humanity? Do humans have a special status in relation to nature? On my account, these questions are at the core of the philosophy of nature that Schelling developed at the turn of the 19th century in response to the increasing instrumentalization of nature. More precisely, I take Schelling’s philosophy of nature to address versions of these same questions, especially as regards (a) the unity of nature beyond the phenomena studied by emerging scientific disciplines such as chemistry and biology, and (b) the status of humanity in relation to this unity. The overall aim of the project is to bring out the contemporary relevance of Schelling’s philosophy of nature by investigating it as an attempt to address these challenges. Counteracting mystical readings of Schelling’s project, I will argue (1) that he is concerned with the elaboration of a unified account of the phenomena studied in the natural sciences; (2) that his theory of self-organization aims to provide such an account; (3) that he conceives of the distinction between humans and non-human forms of nature as a distinction of degree; and (4) that this conception of nature as the manifestation of different degrees of self-organization is relevant to contemporary debates in that it forges a middle pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Supporting EU’s Freight Transport Logistics Action Plan on Green Corridors Issues'.

assistant: **Concept**

The purpose of “SuperGreen” is to promote the development of European freight logistics in an environmentally friendly manner. Environmental factors play an increasing role in all transport modes, and holistic approaches are needed to identify ‘win-win’ solutions. “SuperGreen” will evaluate a series of “green corridors” covering some representative regions and main transport routes throughout Europe.• The selected corridors will be benchmarked based on parameters and key performance indicators covering all aspects related to transport operations and infrastructure. Environmental issues and emissions, external-, infrastructure- and internal costs will be covered to get an overall and realistic picture. Based on this benchmarking, areas and candidates for improvement will be identified (i.e. bottlenecks).• The next step will be to evaluate how “green technologies” may support improving the identified bottlenecks. Among the green technologies considered may be novel propulsion systems, alternative fuels, cargo handling technologies, new terminal technologies or novel concepts relevant for the multimodal “green corridors”. The benchmarking issue is an iterative process.• Next, a similar process needs to be accomplished taking into consideration “smarter” utilisation of available information in the multimodal chain (ICT-flows). An analysis will be made on how this information can be utilised to achieve “greener” logistics along the “green corridors” (e.g. e-freight, Supply Chain Management (SCM), smarter planning, scheduling and tracking & tracing).• Based on these iterative benchmarks and evaluations, new R&D within specific topics may be needed to improve the identified bottlenecks. Recommendations for future calls for R&D proposals will be made.• Last but not least, the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Visualizing the Early Events of Shigella Invasion at the Molecular and Cellular Level' (2007-2013).

assistant: **Innovation**

A key step of Shigella infection is the invasion of epithelial cells of the human colon. The contact with host cells triggers the injection of bacterial effector proteins into the host cells via the type III secretion system (T3SS). The effectors induce massive cytoskeletal remodelling (actin foci). This drives localized membrane ruffling and lamellipodial extensions that envelop and internalize the bacteria. We will investigate at molecular resolution and in three dimensions (3D) how the successive steps of the invasion process are spatially and temporally coordinated. Specifically, we will address where and how the secreting T3SS needles interact with the host cell membrane, how they trigger a spatially- organized signaling response within the host cells, and how the underlying cytoskeleton re-organizes in proximity to the entering bacterium. This will be achieved via correlative light electron microscopy (CLEM) and correlative light electron tomography (CLET). Altogether, our data will illuminate Shigella invasion process at the molecular level and in 3D. Apart from addressing important biological questions, this project will also provide me with the “know-how” of innovative technological tools to study individual events that will be extremely valuable for my success as an independent researcher in the field of host-pathogen interactions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Communists into Liberals: The Transformation and Demise of the Left as Precursor to the Illiberal Turn in Poland' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Communists into Liberals: The Transformation and Demise of the Left as Precursor to the Illiberal Turn in Poland‘Communists into Liberals’ (COMLIB) seeks a historically grounded explanation to the recent ‘illiberal turn’ in Poland by pursuing a new line of inquiry into the country’s transition from state socialism to a European liberal democracy. Rather than focusing on relatively short-term political and economic structural contingencies, the project aims to bring both historical process and agency of key protagonists to the fore as a factor precipitating the developments of the past years. In doing so, three historical processes spanning from 1968 to the mid-2000s are placed in correlation to each other: the demise of communism and transition to liberal democracy in Poland, exchanges of ideas that transcended the Cold War divide of Europe, and the political trajectory of the Polish and European Left. Within this framework, the project examines the agency of a particular group of politicians and activists from the Polish Left and investigates how their ideas and policies set the stage for the recent so-called ‘illiberal turn’ fueled by populism of the Right. In doing so, it aims to re-examine the dynamics of reform communism prior to 1989 as well as its impact on the transition afterwards highlighting two issues: the ‘social-democratisation’ of communism and the ‘neoliberalisation’ of social democracy. COMLIB’s working hypothesis is that the Polish Left’s gradual abandonment of social democratic values during the post-communist transition contributed to their demise in the mid-2000s and facilitated the ‘illiberal turn’. The project’s methodological framework adopts a collective biography approach based on oral history, archival research and qualitative analysis of writ