RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'understanding PLAstic pollutioN effects on the biogeochemical cycle of ElemenTs'.

assistant: **Objectives**

Plastic and microplastic pollution is a global environmental and societal concern. While focus has been placed on assessing the direct impacts on biota, indirect ecological effects are unexplored. Following very recent (and unexpected) laboratory evidences of a considerable binding between metals and altered plastics, I hypothesize that such an interaction can be amplified in environmental conditions due to mechanical, UV and biological degradations during plastic ageing. Plastic can change the budget and cycling of nutrients, micronutrients and toxic metals in different environments (agricultural soils, sediments). If this holds, the implications for the ecosystem might be far-reaching. The mechanisms underpinning ions/metals- plastic interaction are still mostly unexplored.Through PLANET action, I will: i) conduct artificial plastic ageing experiment on selected polymers to create testing materials for following work; ii) characterize the alterations of plastic surface physicochemical properties, iii) run sorption tests with ions and metals in batch experiments under varying pH, salinity, redox potential to disentangle mechanisms, nature and energy of this interaction; iv) build a mathematical frame describing this interaction and its implications for ions/metals distribution in the environment; v) assess model predictions in sediments/water column microcosms to enable inference for ecological effects at different scales.I will work at the Norwegian Institute for Water Research, a top research centre for plastic pollution analysis and environmental modelling. The host owns advanced equipment and laboratory to enable the project. The supervisor is committed to provide training on several core and soft skills and give access to his scientific and stakeholder networks. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bringing 3D cardiac tissues to high throughput for drug discovery screens' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

1.Cardiovascular disease is the number 1 cause of death worldwide. Novel cardiovascular drugs have a high failure rate of 91% in clinical trials. This failure rate is due to lack of proper cardiac models used to find new drugs. Drug discovery studies rely mainly on 2D culture models, which have insufficient predictive value of the human heart. A new in vitro 3D model has been developed by assembling human cardiomyocytes into a three-dimensional strip configuration (3D cardiac strip) that better mimics the native heart tissue. However, this system is not compatible with the high throughput setting needed to perform drug discovery screens. River BioMedics has found a unique solution to miniaturize the human 3D cardiac strips and use them in a high-throughput assay. We combine two innovative technologies: human induced pluripotent stem cell (hiPSC)-cardiac cells and microfluidic systems. The Open-TOP microfluidic technology developed in the group of Prof. v.d. Berg from the University of Twente enables the culturing hundreds of culture chambers automatically and consistently, which is key in high throughput screens. This technology will enable the production and culture of 3D cardiac strips in large numbers, bringing 3D vitro models into a high throughput scale. The end users of this technology are pharma companies performing drug discovery activities and CROs providing drug discovery services. For commercialization of 3DCardiacHTS we plan to partner with an end-user and assess their requirements for the use of such high throughput technology, with the intention of securing their partnership at the end of the project In parallel we will discuss the various partnering options with identified potential Pharma partners and/or CROs the best financial deal structure for partner
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pilot Line For Self Assembly Copolymer Delivery' in the context of a Seventh Framework call.

assistant: **Objectives**

The PLACYD project aims at strengthening the European leadership in the field of advanced lithography. The consortiums gathers the main European Rnull actors along the whole value chain (Material suppliers, equipment suppliers, semiconductor companies, CAD companies, research laboratories) in order to bring the key materials, processes and design tools for Directed Self Assembly  (DSA) Lithography at the required industrial maturity for its introduction at the 1Xnode. PLACYD is focused on challenges that must be addressed to ensure the successful development and integration of Directed Self Assembly Lithography technology to support a high-volume integrated circuit (IC) manufacturing process and prepare the next generation nodes.PLACYD will consist in defining and assembling the first pilot line to produce materials at the heart of the DSA technology. This will include a dedicated material synthesis and formulation pilot line that, as well as all the monitoring and characterisation means:?to define the material specifications and prepare its introduction in IC fabs.?to carry out statistical studies in 300mm line environment to understand correlations between material characteristics and application performances (CDU vs MW dispersity, Defectivity vs composition…) ?to demonstrate DSA technology maturity and compatibility to high volume IC manufacturing, PLACYD will also define and qualify design tools that will allow designing guiding structure properly.Initially, PLACYD will focus on contact shrink and contact doubling application. The project will deliver a Design module through its CAD partner as well as actual electrical demonstrators through its IC manufacturer partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular mechanisms involving enod40 action in nodule' to be submitted under Fifth Framework.

assistant: **Abstract**

Analysis of the enod40 action in the symbiotic process of a legume model at cellular and whole - plant level. Studies on the systemic regulation of nodulation and analysis of the cell-cell communication processes. Identification and characterisation of cellular partners of the enod40 NA. Analysis of the enod40 action in the symbiotic process of a legume model at cellular and whole - plant level. Studies on the systemic regulation of nodulation and analysis of the cell-cell communication processes. Identification and characterisation of cellular partners of the enod40 RNA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Death Rites and the Origins of Social Inequality' in the context of a Horizon 2020 call.

assistant: **Objectives**

The origins of social inequality, a growing topic of concern in our interconnected yet increasingly fragmented world, are rooted in deep prehistory. The point at which these inequalities first begin to emerge, however, and, perhaps more importantly, the manner in which they manifest themselves is the subject of much debate among scholars, many of whom typically associate these sociocultural developments with the earliest settled communities of Southwest Asia (between c.14,500 and 9,000 years ago). As funerary practices are one of the key archaeological indicators through which social relations may be identified in the deep past, this project will investigate the emergence of inequality through the taphonomic analysis of human skeletal remains from a selection of Southwest Asian prehistoric sites using advanced archaeological-scientific techniques that have yet to be applied to this region and time period. Specifically, my research will address the following questions: (1) Can Scanning Electron Microscopy (SEM)/Energy Dispersive Spectroscopy (EDS) and other analytical techniques accurately identify and differentiate between various post-mortem treatments? (2) By incorporating contextual data from the various study sites, can we identify demographic or other selection biases among these post-mortem treatments suggestive of emergent social distinctions? (3) Are there differences in the pattern of funerary treatments observed between the study sites, and do these differences reflect broader temporal trajectories? (4) What lessons can be drawn from the ways in which earlier societies chose to organize themselves?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'HD-MEA-based Neuronal Assays and Network Analysis for Phenotypic Drug Screenings' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In order to overcome the limitations of existing methods for phenotypic drug screening, we propose to develop accurate, label-free, functional neuronal assays for phenotypic/functional drug screening in vitro. These assays will rely on the primary readout of neurons - their electrical signals. We propose to translate and commercialize the assessment of characteristic electrophysiological features of subcellular neuronal components, individual neurons and neuronal networks, all of which can be obtained with high-density microelectrode array technology (HD-MEA), into functional neuronal assays for drug screening. Most of these characteristic features have been developed in the concurrent ERC AdG “neuroXscales”. The model systems for the PoC will include commercially available hiPSC-derived neuronal cell lines. The PoC will be performed in collaboration with the company MaxWell Biosystems AG (http://www.mxwbio.com/), which commercializes multi-well HD-MEA platforms for use in research labs and industry.


**Keywords:** High-density microelectrode arrays, extracellular electrophysiology, Human iPSC-derived neurons, drug testing, neuronal assays
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ALGBIO - CO2 capture from flue gas and phycoremediation of wastewater via microalgae for carbon negative biofuels/bioplastic production with the circular economy model' (ALGBIO).

assistant: **Concept**

The level of CO2 in the atmosphere increased two times compared to the pre-industrial period. The biggest reasons for this are the flue gases of the factories and greenhouse gas emissions in transportation. Billion tons of industrial wastewater and CO2 from the same factories continue to destroy our biodiversity in sea/lakes/rivers because of mucilage, eutrophication, ocean acidification, and deoxygenation.With global production sectors responsible for one-fifth of carbon emissions – consuming 54% of the world’s energy sources – there is an urgent need for manufacturing companies to minimize CO2 emissions and optimize energy consumption. ALGBIO provides production facilities and industry with a circular economy model service, where they can capture their carbon, purify their waste, and produce their energies and raw materials.ALGBIO will help the industry lower the environmental impact of the wastewater and flue gasses while turning the waste into energy with its circular economy model and patent-pending technology.ALGBIO’s bioremediation technology is called phycoremediation, which can be defined as the use of microalgae for the removal or biotransformation of pollutants, including nutrients and xenobiotics from wastewater and CO2 from waste air. Rubisco enzyme activities of ALGBIO's metabolic engineering algae species have been increased. In this way, ALGBIO realizes carbon capture more efficiently and cost-effectively. With advanced phycoremediation, ALGBIO can remove up to 95% of biological oxygen demand, chemical oxygen demand, nitrogen, phosphorus and conductivity from industrial wastewater and sewage compared to an un-efficient, carbon-positive conventional bacterial treatment. The successful completion of the ALGBIO project will enable us to identify the pilot c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New and Old Histones in Epigenetic Cell Memory' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cell type specific organization of DNA into chromatin is an important determinant of gene expression and cell identity. During cell division, epigenetic information in chromatin must be transmitted to daughter cells in order to maintain cell identity or commit to a developmental program. However, it remains unknown how epigenetic states are inherited during cell division. Elucidating molecular mechanisms underlying epigenetic cell memory thus represents a major challenge in biology critical to understand development and disease.Chromatin undergoes genome-wide disruption during DNA replication and histone marks are diluted 2-fold due to new histone deposition. Yet, how this impacts on establishment and maintenance of gene expression programs is not known. I hypothesize that chromatin replication represents a critical window for epigenetic cell memory and cell fate decisions, and predict that three histone-based processes play critical roles in guarding cell identity: 1) new histone deposition to regulate nucleosome occupancy and transcription factor (TF) binding, 2) accurate transmission of old modified histones by dedicated recycling machinery, and 3) recruitment of regulatory proteins to new and old histones to direct epigenome maintenance. To dissect these events mechanistically and test causal roles in cell fate decisions, I propose a research program integrating explorative proteomics and histone chaperone structure-function analysis with stem cell biology and new cutting-edge genomic tools developed by my research group. The proposed research will 1) identify novel mechanisms of histone chaperoning and deposition specific to new and old histones, 2) reveal how nucleosome assembly govern TF binding during DNA replication, and 3) address the significance of old histo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of an emerging technology based on micropyrotechnic. Applicative Exploration of Energetic Microsystems: MICROPYROSYSTEMS' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Getting enough force out of a silicon microsystem to deliver a sufficient amount of mechanical work is a challenge. MicroPyroSystems are a new generation of microsystems that could deliver either thrust force or pressure wave within a submillimeter volume of silicon by coupling explosives with silicon chips. MicroPyros is a multidisciplinary basic research project associating research institutions and experts in microsystems, micro technologies, micro mechanical experimentation, as well as in physical and chemical modelling and electronic circuitry. The MicroPyros program is built around 4 main key actions: develop advanced technological tools;build a design software based on theoretical models;set up experimental means and demonstrate one concrete application. The motivation behind MicroPyros is to develop generic design technical and technological tools to make MicroPyroSystems work.Getting enough force out of a silicon microsystem to deliver a sufficient amount of mechanical work is a challenge. MicroPyroSystems are a new generation of microsystems that could deliver either thrust force or pressure wave within a submillimeter volume of silicon by coupling explosives with silicon chips. MicroPyros is a multidisciplinary basic research project associating research institutions and experts in microsystems, micro technologies, micro mechanical experimentation, as well as in physical and chemical modelling and electronic circuitry. The MicroPyros program is built around 4 main key actions: develop advanced technological tools;build a design software based on theoretical models;set up experimental means and demonstrate one concrete application. The motivation behind MicroPyros is to develop generic design technical and technological tools to make MicroPyroSystems work.OBJE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EEB ICT ClustERS' (EEBERS).

assistant: **Innovation**

EEBERS focus on identifying opportunities for synergies in ICT related RTD in the EeB (energy efficient buildings) domain and to engage stakeholders in networking for future RTD and exploitation of  results. There areabout 134 EeB direct and indirectly related projects that will be active beyond 2014. From these about 86 are likely to add¬ress ICT as one of their key priorities. – These projects are the primary target of this CSA.The tangible objectives of the EEBERS project are to:• Engage relevant stakeholders in identifying and exploiting opportunities for synergy.• Analyse and consolidate latest developments in the EeB domain.• Stimulate cooperation for future RTD and exploitation of results.The key factors to be considered by EEBERS when assessing RTD&I activities include:• Key stakeholders and links between them.• Project topics and links between them.• Project results and their TRL levels.• Links with innovation and technology transfer initiatives.The project will connect relevant innovation stakeholders with R&D results and with EU, national and regional levels initiatives within the construction, energy and ICT sectors. EEBERS will impact on speed up wide-scale deployment of solutions and services for building energy-efficiency. The consortium includes 3 academic and 1 industrial organisations from 4 countries in different EU climate zones. Together these are involved in a total of 39 EeB projects, from which 33 deal with ICT-related topics. The consortium will engage with relevant stakeholders in an early stage of the project, as well as with other similar ongoing CSA project.


**Keywords:** EeB, Impact, clustering, technology transfer, Buildings,  dissemination, ICT, R&D priotities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ARgon ImAging DetectioN chambEr' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This proposal outlines a plan to combine Charge Couple Device (CCD) camera technologies with two-phase Liquid Argon Time Projection Chambers (LAr TPCs) utilising THick Gas Electron Multipliers (THGEMs) to evolve a next generation neutrino detector. This will be an entirely new readout option, and will open the prospect of revolutionary discoveries in fundamental particle physics. Furthermore, the Compton imaging power of this technology will be developed, which will have diverse applications in novel medical imaging techniques and detection of concealed nuclear materials.Colossal LAr TPCs are the future for long-baseline-neutrino-oscillation physics around which the international neutrino community is rallying, with the common goal of discovering new physics beyond the Standard Model, which holds the key to our understanding of phenomena such as dark matter and the matter-antimatter asymmetry.I have successfully provided a first demonstration of photographic capturing of muon tracks and single gammas interacting in the Liverpool 40 l LAr TPC using a CCD camera and THGEM. I propose an ambitious project of extensive research to mature this innovative LAr optical readout technology. I will construct a 650 l LAr TPC with integrated CCD/THGEM readout, capable of containing sufficient tracking information for full development and characterisation of this novel detector, with the goal of realising this game-changing technology in the planned future giant LAr TPCs. Camera readout can replace the current charge readout technology and associated scalability complications, and the excellent energy thresholds will enhance detector performance as well as extend research avenues to lower energy fundamental physics. Also, I will explore the Compton imaging capability of LAr CCD/THGEM