RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Human Pluripotent Stem Cells: the new heart patient?'.

assistant: **Innovation**

The ability to generate pluripotent stem cells (iPSC) by reprogramming somatic tissues is arguably the greatest breakthrough in biomedical science of the last decade. The most inaccessible cells of the body can now be derived repeatedly from any individual. This could have a huge impact on understanding disease and the development of new therapeutic drugs but it will require a new level of sophistication in bioassays to create disease models and monitor disease phenotypes. The project I propose here will take up this challenge for the cardiovascular system, creating new human models of heart failure and vascular disease that presently do not exist. My group is uniquely positioned in Europe to realize these ambitions through more than a decade of research on cardiac and vascular cells from human embryonic stem cells and more recently hiPSC; its present location in Leiden University Medical Centre is optimal for fostering clinical links. My group is one of few worldwide that uses conventional homologous recombination in human PSCs. My aims here are (1) develop protocols for differentiating all cells of the heart (2) engineer synthetic and native human myocardium that models healthy tissue and common disease states and (3) generate sets of isogenic diseased hPSC to model pathogenesis. This will be realized by deriving lineage marked “rainbow coloured” reporter hPSC lines, introducing selected (immature) cardiovascular cells into engineered constructs and subjecting them to mechanical/biochemical stress factors like cyclic contraction and fluid flow that would normally induce maturation and disease. The constructs will support simultaneous measurement of functional tissue parameters and include hiPSC from relevant diseases, genetically or pharmacologically rescued and isoge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nano-diamond building blocks for micro-device applications' (NANODIA) targeting Seventh Framework.

assistant: **Abstract**

The aim of the proposed project is to initiate a new research line on the development of nano-diamond building blocks for micro-devices. Diamond is a superlative engineering material combining exceptional thermal, mechanical, and chemical properties. Nano-grained diamond is of large scientific and technological interest since it could lead to several breakthroughs in micro-engineering, like e.g. for the synthesis of micro-electromechanical systems. Such nano-diamond deposits could replace silicon and other well-established materials that are unsuitable under extreme conditions, and could help to tackle the reliability issues due to friction and wear in numerous micro-device applications. This project will address several key aspects related to the growth, structure, and function of nano-diamond deposits that still impede their breakthrough for micro-scale applications.The key objective is the controlled synthesis of complex-shaped, 3-D micro-structured nano-diamond deposits with large aspect ratio displaying very low surface roughness, high film conformality, and well-controlled material properties. That will be achieved by acquiring a deeper understanding and control of the early stage formation of nano-diamond thin films on micro-patterned substrates.The Fellow will combine advanced diamond growth techniques with new developments in atomic layer deposition and miniature device fabrication. He will develop a two-pronged approach using experimental procedures and computer simulations to understand and tailor the nucleation and growth dynamics of nano-diamond thin films. Surface micromachining technology will then be applied for micro-patterning the nano-diamond. For the first time, recently developed micro-device tribometers will be used to assess the tribomechanical pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evolutionary model supported design of whole-cell biocatalysts' (BIOCELL) targeting Fifth Framework.

assistant: **Abstract**

Biocatalysis is moving from an enabling tool towards a lowest cost and resource-saving approach for the production of chemicals. The research group's endeavor is to transfer the widely acknowledged potential of biocatalysis into commercial applications. One focus of our group is to design and apply whole-cell biocatalysts (-cell factories) that can perform multi-step reactions in a single cell and one reactor. This concept has an enormous commercial potential: Complex processes requiring multiple steps often performed under different conditions (temperature, pressure, pH) can be substituted by very simple and cheaper single pot processes. Another benefit is that expensive enzyme purification of the different enzymes often limiting commercial applications is no longer required and the biocatalyst can be produced in a single instead of multiple fermentations. In order to rationally design and optimize these biocatalysts bottlenecks in the newly formed pathway have to be identified by simulating the coupled reactions including mass transfer through cell membranes based on a computer model. Identification of kinetic parameters and the bottlenecks will then be used to target specific enzymes properties (selectivity. stability. activity) for optimization by directed evolution and genetic engineering means (adaptation of expression levels). Important to the success will be an interdisciplinary teamwork of scientists for which the project house offers an excellent supportive framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MEDRESET.A comprehensive, integrated,and bottom-up approach to reset our understanding of the Mediterranean space, remap the region,and reconstruct inclusive, responsive,and flexible EU policies in it' under Horizon 2020.

assistant: **Concept**

Euro-Mediterranean policies, as well as research on them, have been characterized by a Euro-centric approach based on a narrow geopolitical construction of the Mediterranean. Moreover, stakeholders, policy instruments, and policy issues have been defined from a European standpoint, marginalizing the perspectives and needs of local states and people, and ignoring the role played by new and powerful regional and global actors. In an increasingly multipolar world, overcoming this Euro-centric approach is key for Europe to play a more meaningful role in the region. Thus, MEDRESET aims to reset our understanding of the Mediterranean and develop alternative visions for a new partnership and corresponding EU policies, reinventing a future role for the EU as an inclusive, flexible, and responsive ‘actor’ in the region. This will be achieved through an integrated research design which is in three phases: it 1) de-constructs the EU construction of the Mediterranean, 2) counters it by mapping the region on the geopolitical level and in four key policy areas (political ideas, agriculture and water, industry and energy, migration and mobility) alongside a three-dimensional framework (stakeholders, policy instruments, policy issues), which directly feeds into 3) a reconstruction of a new role for the EU, enhancing its ability to exert reflexive leadership and thus its relevance in the region. Embedded in an interdisciplinary research team, as well as in a civil society and media network, MEDRESET evaluates the effectiveness and potential of EU policies by investigating whether current policies still match the changing geopolitical configuration of the Mediterranean area. The perceptions of EU policies and the reasons for their successes or failures are assessed by surveying top-down
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Developing methodology for advanced systems testing'.

assistant: **Concept**

This project addresses the area of Systems Testing (ST), which is a branch of Systems Engineering. ST is critical in insuring high quality products by all manufacturing industries. ST is a process designed to identify problems and manage economic risks during the entire product lifecycle. The ultimate aim of ST is to assure that products fulfils customers needs. The aim of SysTest is to develop a generic ST methodology and processes as well as evolve an ST economic model to optimise the ST process. The aim is that these will be tailorable in order to fully respond to different risk and quality objectives, different stages of systems lifecycles and support different industrial sectors. The overall goals are - decrease the projects development cost and time-to-market by 10% - improve by 10% the following system qualities: correctness, reliability, robustness, performance, safety and security.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Securing Holistic and Impactful Food Systems Transformation with Novel Foods based on alternative proteins'.

assistant: **Innovation**

The current food system is unsustainable and underperforming, having high environmental and socio-economic costs, while still failing to ensure food and nutrition equity for all. Dietary shifts towards novel foods based on alternative protein sources (NFAP; proteins derived from insect, fungi, bacteria, micro and macro algae and agriculture and aquaculture by-products), provide a unique opportunity to reduce consumption of animal-based proteins potentially minimizing the impact of the Food Systems.  However, knowledge regarding the environmental, economic and social impact of the widespread production, provision and consumption of NFAP is very limited and not integrated into a holistic vision of the food system able to identify trade-offs, interaction between food system actors and second and third order impacts. The goal of EPIC-SHIFT is to provide an unprecedented, independent, solid knowledge base on the sustainability (env., eco. and soc.) aspects of NFAP as options for protein diversification for human consumption. Considering that the contribution of each NFAP types to reorganize the food systems may differ, EPIC-SHIFT applies a quadruple helix innovation model in its multi-actor approach to roadmap the sustainable development of NFAP for Planetary Health Diets. Designed as a think-tank and adopting Food Systems Thinking approach, EPIC-SHIFT will provide a multidimensional impact assessment of 7 NFAP (from protein type to product level) at scale complemented with the necessary recommendations for food environments, marketing, regulatory approval, infrastructure and investment needed to support long-term market growth. EPIC-SHIFT integrated scenario analysis will further result in decision support tools that will inform policy and decision-making about the trajecto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Optical Microresonator Stabilization Module – Creating Frequency Stabilized Lasers'.

assistant: **Concept**

Laser systems are ubiquitous now, but advancing technology is always pushing the limits requiring smaller and more stable lasers. An optical microresonator is a tiny device that can act as a miniature compact optical reference system, enabling tighter frequency control in laser systems. This will enable the creation of compact narrow linewidth lasers in a variety wavelength ranges. Such systems are currently needed in a diverse array of market segments: timekeeping, LIDAR, gas sensing, oil well monitoring, and scientific laboratories. This proposal combines optical microresonators with microfabricated optical waveguide technology developed during the FET-Open iQUOEMS program to create a robustly packaged system that is resistant to strong temperature and vibrational perturbations.  The result will be successfully demonstrated prototype that will open up new markets for a start-up company being developed at EPFL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ENGineering extracellular matrix-based de novo proteins with high Affinity to Growth factors for Enhancing bone regeneration' (ENGAGE) targeting Horizon 2020.

assistant: **Abstract**

The successful regeneration of bone tissue to replace areas of bone loss in large defects remains a significant clinical challenge. Efforts have concentrated in the design of biomaterials using biomimetic strategies based on installing bioactivity at their surface using proteins from the extracellular matrix (ECM). Some of these ECM proteins contain domains capable of binding growth factors (GFs). This is the case of the Heparin Binding II (HBII) domain of fibronectin, which has the capacity to bind Bone Morphogenetic Proteins (BMPs). Among them, BMP-2 is known to be a potent osteoinductive molecule. However, the lack of specificity of HBII for BMP-2 limits its application. ENGAGE project aims to identify the hotspot sequences involved HBII-BMP-2 interaction and develop de novo proteins with high affinity to BMP-2 to further exploit them in hydrogel biomaterials for enhancing bone regeneration. To this end, HBII-BMP-2 will be co-crystallized to identify the sequences involved in the interaction. Based on these sequences, de novo mini-binders will be designed using Rosetta computational methodologies and optimized to have high-affinity to BMP-2. The osteoinductive capacity of the selected molecules will be analyzed and the optimal candidates will be used to functionalize hydrogel substrates. In this way, ENGAGE will open the possibility to obtain hydrogels able to sequester specific GFs from the extracellular fluids, avoiding the use of exogenous growth factors and their undesired side effects.The candidate will be trained in new computational and lab skills for protein design under the supervision of a world leader in de novo protein design. These methodologies will be transferred to the Spanish research community for developing novel proteins for biomedical application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A molecular model of the microsporidian infection apparatus' (PolTube) targeting Horizon 2020.

assistant: **Abstract**

Microsporidia are opportunistic fungal pathogens that infect organisms as evolutionarily divergent as protists and mammals. Due to their growing impact on the global food supply chain, the environment, and human health, these unusual spore-forming organisms have been classified as emerging pathogens of high priority. Intriguing cell biological features that are central to microsporidian infectivity and pose challenges to drug development are poorly understood due to a lack of structural information and the absence of genetic tools. As energy parasites, microsporidia survive with the smallest eukaryotic genome and without classical mitochondria through an obligate intracellular lifestyle. A fascinating infection mechanism, which involves a long, hollow protein structure, is essential for efficient host invasion. The microsporidia-specific infection apparatus consists of several structural proteins that form the polar tube, which is used to inject the entire cytoplasm from the infectious spore into the host cell. Here, we will use an innovative approach to provide the structural and mechanistic basis of the microsporidian infection mechanism by using cutting-edge structural biology techniques and novel developed in-vivo tools. By studying the endogenous polar-tube, we will identify new elements and provide an architectural model of the invasion organelle. Reconstitution and biochemical characterization of the major components of the polar tube, followed by high-resolution cryo-EM studies, will unravel the polar tube protein interaction network and provide near-atomic information to complement the architectural model. Together with the development of genetic methods to tag, visualize and manipulate components in-vivo, we will provide a comprehensive model of the infection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Inkjet Printed Ultrafast Batteries and Large Integrated Capacitors' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Energy storage has become a global concern in modern society. With his ERC Advanced grant, Prof. Östling, an expert in solid state electronics from the KTH Royal Institute of Technology in Sweden, is trying to develop emerging devices based on silicon technology but with other materials than silicon, such as graphene and its analogue MoS2. These unique materials offer opportunities to novel applications, especially those related to energy storage. Prof. Östling and his team have recently developed an efficient inkjet printing technique to reliably deposit these materials at high resolution. They have been able to directly print graphene-based supercapacitors with good performance. In the new PoC project, they will employ the inkjet printing techniques to demonstrate a novel type of energy storage devices which are expected to possess both high energy density and high power density, and establish initial commercialisation steps. Although the novel devices have complicated structure, the full-printing solution will not evidently increase the production cost. Considering the improved performance, the effective cost is actually reduced. Furthermore, the printing solution facilitates scaling up during commercialisation. These printed ultrafast batteries have great potential to meet the urgent and increasing demands from the rapid growth of portable electronic devices and electric vehicles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Graded Membranes for Energy Efficient New Generation Carbon Capture Process' in the context of a Seventh Framework call.

assistant: **Objectives**

Major sources for human made CO2 emissions comprise the energy and the industrial sector including cement production. One of the most appropriate concepts to capture CO2 from such point sources is the oxyfuel combustion. The main energy demand for this method results from the O2 generation, which is usually done by air liquefaction. This energy demand can substantially be lowered using thermally integrated separation modules based on ceramic oxygen transport membranes (OTM). It is least if the OTM is integrated in a 4-end mode, which entails that the permeating oxygen is swept and directly diluted using recirculated flue gas. Up to 60% reduction in capture energy demand compared to cryogenic air separation and up to 40% reduction compared to post-combustion capture approaches can be achieved.GREEN-CC will provide a new generation high-efficiency capture process based on oxyfuel combustion. The focus lies on the development of clear integration approaches for OTM-modules in power plants and cement industry considering minimum energy penalty related to common CO2 capture and integration in existing plants with minimum capital investment. This will be attained by using advanced process simulations and cost calculations. GREEN-CC will also explore the use of OTM-based oxyfuel combustion in different highly energy-demanding industrial processes, e.g. oil refining and petrochemical industry.However, highly permeable membrane materials show a chemical instability against CO2 and other flue gas components. One major challenge faced by GREEN-CC is therefore to identify and develop membrane materials, components, and a PoC-module for the 4-end mode OTM integration. The desired membrane assembly will consist of a thin membrane layer supported on substrates with engineered porosity