RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'ASSESSMENT OF ADDITIVE MANUFACTURING LIMITS FOR ECO-DESIGN OPTIMIZATION IN HEAT EXCHANGERS'.

assistant: **Objectives**

Selective Laser Melting (SLM) is key for improved design and production process of aviation parts. Applied to heat exchangers (HX), it could dramatically improve global eco‐efficiency through access to radically new designs and open horizons in terms of shape, weight, efficiency. Nevertheless, some questions need to be solved regarding capability of Additive Manufacturing (AM) to manufacture thin walls, small holes/gaps, low overhang angle, resulting surface roughness and mechanical strength.AManECO aims to enhance knowledge of metal AM and, specifically, the capability of SLM process to manufacture thin layers and wall thickness with adequate surface finish using AlSi7Mg0.6 and INCO 718 materials. In particular, to investigate aerothermal and mechanical performance of thin walls, to predict them in the design of AM-HX and consequently, be able to optimize the HX´s design process in an Eco-friendly way after knowing the limits of the metal AM technology.For this purpose, testing samples will be designed and manufactured to characterize in terms of surface properties, pressure resistance and gas tightness evaluation, equivalent stiffness and aerothermal properties. Besides, numerical studies based on FEM and CFD simulations will be done. Then, a representative design of HX based on the initial SOA of AM limitations will be optimized with the gained knowledge. These designs, before and after optimization, will be processed and characterized. Then, a Life Cycle Inventory (LCI) database will be created to evaluate the ECO potential of the innovative HX.AManECO will enable to:- Increase efficiency of HX up to 10%. - Reduce the overall of HX manufacturing costs by 30%. - Reduce material waste and scraps by 15 % per component. - Reduce time-to market up to 1 month.A multidisci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Gene silencing-based functional screening for genes regulating invasion in human cancer cells' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The proposed project uses a RNA interference-based loss-of-function genetic screen in cancer cells to identify and study proteins with a role in tumor cell invasion. A retroviral vector-based human RNAi library and a set of syntethics iRNAs will be used to suppress the expression of specific genes in cancer cells. The library targets around 8000 human genes selected for their association with cancer and other human diseases and include entire gene families suitable for being therapeutical targets. The genes in the set have been selected for their possible implication in actin dynamics and migration. I will check for abnormal invasion phenotypes on these cells in a modification of a classical cell-based in vitro invasion assay on 3-D collagen matrices in resp onse to hepatocyte growth factor/scatter factor (HGF/SF), a protein that induces the migration and invasion of various types of cancer cells. For this study I plan to use initially the PC-3 human prostate cancer cell line that invade well in response to HG F and is suitable for the use of RNAi in gene silencing. Later on results obtained will be confirmed in another model cell line, the BE colon carcinoma cell line, as well as in another prostate cancer line with a different metastatic potential. At the beginning the invasion system will be exploited to analyse in detail the contribution to tumour invasion of the Rho family of small GTPases followed later on with a high-throughput screen using a subset of RNAi constructs targeting all the human protein kinases and a selective large-scale screen with the whole library to identify new regulators of cancer cell invasion that would potentially serve as new therapeutical targets against cancer. This project will also complete the researcher and apos;s expertise in basic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Total Synthesis of Noroxymorphone' to be submitted under Horizon Europe.

assistant: **Abstract**

Opiates, derived from the poppy plant and exemplified by morphine, are important medicines for pain and other disorders because of their agonistic action on the opioid receptors. However, many opiates have bad side effects such as respiratory depression, sedation, and constipation. They can be highly addictive, which leads to abuse and overdose deaths. To address these issues, “nal-compounds” have been developed, which attenuate the effects of opioid receptor agonists, making them useful for treating opioid overdose and abuse; examples include the World Health Organization essential medicines naloxone and naltrexone, which are µ-opioid receptor antagonists. Other nal-compounds include nalbuphine, nalmefene, and nalfurafine, which have a range of clinical uses. Noroxymorphone is a common late-stage intermediate in the synthesis of nal-compounds, which makes its synthesis a critical task. Noroxymorphone is manufactured semisynthetically from the poppy-derived compounds oripavine and thebaine. However, the quantity of oripavine and thebaine in poppies is low compared to the most abundant compound morphine. In addition, poppy cultivation is problematic; it is highly space- and resource-intensive, and could be affected by floods, droughts, disease, and geopolitics. Illegal poppy diversion also fuels the illicit narcotic trade (e.g., heroin), resulting in huge societal problems. Therefore, breaking human reliance on the poppy by developing an industrially viable total synthesis of noroxymorphone from inexpensive feedstocks would be game-changing.Dozens of total syntheses of morphine and related compounds are already known, including one synthesis of noroxymorphone. However, none are remotely competitive with semisynthesis from poppy raw materials because of their step-count.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Uncovering molecular mechanisms of active transcriptional repression.' under Horizon 2020.

assistant: **Concept**

Animal development and homeostasis critically depend on the accurate regulation of gene expression, which includes the silencing of genes that should not be active. Silencing or repression of transcription is mediated by a specific class of transcription factors termed repressors that, typically via the recruitment of co-repressors, can dominantly suppress transcription, even in the presence of activating cues. While the importance of such “active repression” is emphasized by severe developmental defects and diseases like cancer that can result when repressors are mutated, how repressors function is not well understood. In particular, how repression is achieved mechanistically and whether all repressors can repress all activators has remained elusive.   Here, I propose to study the functional properties of repressors and the mechanisms of active repression by an interdisciplinary approach that combines genome-wide experiments, targeted assays, and bioinformatics. Specifically, I will use high-throughput functional assays in combination with the Gal4/UAS system to systematically test whether transcriptional repressors can repress all active promoters and enhancers or only specific ones but not others. Further, I aim to uncover the mechanisms behind active repression by recruiting repressors to active promoters and enhancers in a rapidly inducible manner, using chemically-inducible-proximity, to then assess the changes to DNA accessibility, histone modifications, and Pol II activity. In addition, I will measure differential protein composition and PTMs at active genomic regions, before and during induced repression. These approaches should identify critical molecular events, proteins, or PTMs and allow me to test their causal involvement in repression.   This project has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Competition between subjunctive and infinitive in the history of German, Balkan Slavic and Romance languages' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The project focuses on the area of language change and evolution (i.e. diachronic linguistics), specifically as it pertains to the use of subjunctive (Subj) and infinitive (Inf). Subj and Inf are involved in the phenomenon of grammatical competition (CompSubjInf) across different groups of European languages: (i) Germanic (e.g. German, Swedish) largely replaced Subj with Inf; (ii) Balkan (e.g. Greek, Bulgarian) underwent a reverse process, replacing Inf with Subj; (iii) Romance (e.g. Italian, French) still use both Subj and Inf, but employ them in different syntactic contexts. CompSubjInf represents one of the important grammatical aspects underlying linguistic diversity between European languages, but the phenomenon has not yet been sufficiently studied from a scientific perspective. The state-of-the-art literature provides a comprehensive typological overview of different present-day manifestations of CompSubjInf across languages in (i-iii). Nevertheless, the diachronic developments that led to the situation we observe today remain understudied. The present project proposes to fill in this gap. The applicant will study several representative languages for each group outlined in (i-iii): German for (i), Balkan Slavic (e.g. Bulgarian, Serbian) for (ii), and Italian and French for (iii). The overall objective of the project is two-fold: firstly, describe the evolving historical tendencies pertaining to CompSubjInf in these languages; secondly, identify the underlying factors (both linguistic and extra-linguistic) that led to these tendencies. The applicant is well-suited to achieve these goals due to the extensive training in theoretical linguistic analysis that he has already received, which will be combined with additional training on the descriptive, data-oriented sid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification and characterization of long non-coding RNAs as drivers of stemness in hematopoietic stem cells and leukemia.' in the context of a Horizon Europe call.

assistant: **Objectives**

Hematopoietic stem cells (HSCs) are a unique population defined by their self-renewal capacity and the potential to give rise to all blood lineages. A complete understanding of the specific mechanisms controlling HSC self-renewal and multipotency is still lacking. This knowledge is fundamental to improve ex vivo HSC expansion with therapeutic purposes and to unveil the mechanisms that promote aberrant cellular growth in leukemia. Long non-coding RNAs (lncRNAs) are emerging as novel players of normal development and physiology and their dysregulation has been associated with multiple cancer types. Recent data suggests that lncRNAs may also act as molecular determinants of the balance between self-renewal and differentiation in HSCs. However, because of traditional limitations in RNA-profiling strategies, current lncRNA catalogs are still incomplete, representing likely only a fraction of the whole lncRNA repertoire expressed in cells. In this proposal, I aim to identify novel lncRNAs specifically involved in the regulation of HSC identity, to ultimately understand their function in normal hematopoiesis and leukemia. For this, I will construct a comprehensive HSC-specific lncRNA catalog through deep total-RNA sequencing of mouse HSCs and their closest cell descendants. I will then infer lncRNA functions through robust computational analyses and validate selected candidates in-vitro. Finally, I will investigate the role of HSC-specific lncRNAs in vivo, using a T-cell acute lymphoblastic leukemia mouse model. This work will extend our knowledge on lncRNAs, on the molecular mechanisms of HSC identity and on how their dysregulation leads to leukemia. By performing this project I will gain first-hand experience in normal and malignant hematopoiesis while reinforcing my experti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced methods for improved child safety' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The CHILD project uses as a basis research undertaken in the CREST project SMT4-CT95-2019.It addresses many issues that are researched in other EC projects in relation to adult vehicle occupants, but about which little is known for children. The objectives are to increase the level of knowledge in areas regarding children and to use the information in the applications of child restraint design, evaluation testing and regulation. The outputs include an invaluable source of real world crash injury data, real and virtual reconstructions of such cases, child based simulation methods and tools, including human and dummy models for some body segments, further evaluation of the Q child dummies, child injury criteria and risk curves for different ages and body segments. All this information will be consolidated in the context of child restraint testing and regulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ACROSS THE BORDERS EATMS EFFECT' under Fourth Framework.

assistant: **Concept**

The purpose is to carry out an assessment of the interface effects at the ECAC b orders deriving from EATMS implementation, together with the identification of s ome possible technical and operational solutions to any problem discovered. Desp ite many efforts to harmonize and integrate continental European ATM, it is like ly to happen that several factors will keep it as on interconnected system, form ed by dissimilar elements. In fact, there is probably just one realistic option towards the development of continental ATM: evolution along different paths and at various speeds under the responsibility of each individual State. The overall capacity of the entire system will be limited by the lowest capacity area in th e system, as a peripheral states capacity shortage will deny access to the traff ic originating from the centre of the continent. The airspace capacity level of ECAC border States along routes connecting European Union crucial transport mark et (America, Africa, Far East) shall be considered of vital strategical interest . The common features, on the basis of which groups of countries could be define d similar, allow to denote those homogeneous areas whose interests, constraints, technological state of the art and users operational matters and requirements a re analogous. The stakes of this game are represented by the possibility of opti mising investments and results in terms of capacity on providers side, and trans port links development on users side. The 2 greatest air markets are America and the Far East, and European airlines have to compete there. The demand for incre asing number of flights on routes to and from such regions will explode far beyo nd the actual capacities already limited in the core area. The homogeneous area" concept has been defined
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Three-dimensional nanoscale magnetic structures' (3DNANOMAG), addressing dissemination and exploitation.

assistant: **Impact**

Three-dimensional (3D) nanomagnets, with unconventional spin and topological properties, are very promising systems for the future development of greener, more capable, multi-functional technologies. However, the significant experimental challenges associated with the fabrication and probing of 3D nanoscale geometries and spin configurations, have restricted most studies to date in this field, to either computational and theoretical works, or experiments in simple 3D geometries that do not fully exploit the potential of moving to three dimensions.Making use of recently-developed 3D nano-printing and magneto-optical tools, the 3DNANOMAG project will carry out first experimental investigations in ultra-advanced nanomagnetic systems with a variety of complex 3D geometries, multi-layered materials and chiral spin configurations. These techniques will be combined with state-of-the-art magnetic microscopy and simulations, in collaboration with worldwide experts.The project will study 3D nanowire conduits, where the magnetic state and propagation properties of domain walls and skyrmionic textures will be tailored via symmetry-breaking nano-curvature effects, leading to ground-breaking investigations in 3D spintronic devices. In addition, new types of topologically non-trivial spin textures and localised magnetic defects will be realised via the pioneering exploitation of 3D geometrical effects in multi-strand nanowires with strong interwire coupling.To carry out the project, 2.6M are requested, which will be employed to form a research team working for 60 months, use of microscopy facilities and the purchase of nanofabrication equipment specially designed for the investigation of 3D nanostructures.


**Keywords:** Nanotechnology, nanomagnetism, spintronics, magneto-optics, 3D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Thermal Imaging Enhancement with Super-Resolution' in the context of a Seventh Framework call.

assistant: **Objectives**

High resolution (HR) images are of interest in many fields such as medical imaging, surveillance, and satellite imaging. Signal processing based resolution enhancement methods have been finding increasing use due to the limitations in the physical principles as well as limitations in optics and electronics technology. However, none of the methods in curent use performs satisfactorily when appliedto accurate registration. Robust registration models and solutions for multiple object motion and occlusions should be incorporated into these methods. We propose using a super-resolution (SR) reconstruction algorithm based on least squares (LS) filtering combined with a spatiotemporal classification algorithm. Using these classified imageswith corresponding LS filter modes and classes, we intend to generate higher resolution images. Registration and multiple object movementswill be incorporated into different LS filter classes without requiring accurate estimation of these changes. The proposed technique will be demonstrated on surveillance images acquired from thermal imaging sensors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Haptic E-Model: A Computational Model of Human Sensory-Motor Performance in Haptic Manipulation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Haptic interaction refers to the form of interaction with a real or virtual environment based on the sense of touch. As the user experiences and interacts with an environment through a haptic system, the haptic system directly or indirectly alters the user's perception and motor control. Therefore, understanding the effects of the haptic system on the perception and motor control is important. The purpose of this study is the development of a computational model of the human haptic sensory-motor system for quantitatively capturing the user performance in haptic manipulation tasks. The developed computational model, which we call the haptic e-model, will be an objective tool for evaluation of haptic systems with emphasis on human operator's sensory-motor performance. Specifically, the developed haptic e-model will be composed of a benchmark suite of representative haptic manipulation tasks, task performance measures, and models for human perception and motor control. The haptic e-model will be used as a benchmark evaluation model by the research community to evaluate effectiveness and performance of haptic systems, components, and algorithms. It will also be a computational tool that can be easily integrated into the design cycle of haptic systems, and facilitate quantitative analysis of design choices throughout system development.