RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The European Social Survey Infrastructure Preparatory Phase' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The European Social Survey (ESS) has three main objectives firstly to produce rigorous trend data at a national and European level about people’s social, political and moral values in the context of Europe’s changing institutions; to remedy longstanding deficiencies in methods of cross-national social measurement, particularly in respect of public attitudes and to bring social indicators into closer focus as a means of monitoring the quality of life across European nations. ESS data and supporting documentation are freely and swiftly available to all and have already attracted over 13,000 registered users. Many books and journal articles arising from the ESS have already appeared; many more are in preparation. Now starting its fourth biennial Round, the ESS is a pioneering example of the principles and practices behind the European Research Area, with funding from both the EC and over 20 Research Councils. We now seek to consolidate the achievements to date and prepare the project for its transition into an upgraded and sustainable Infrastructure. Although always envisaged as a time series, the future of the ESS has remained uncertain owing to a lack of sustained funding. Its diverse ad hoc funding arrangements that have sufficed so far are now in need of transformation, alongside a review of its governance arrangements. The upgrade we seek is to secure continuity and expansion of the ESS as a lasting infrastructure that continues to contribute substantively and methodologically to European scientific practice and good governance. The Preparatory Phase will focus on the financial, legal and governance work required for an upgraded ESS. Building on existing ESS structures, the scientific partners will work closely with the nine national research councils in the Consortiu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Indeterminism Ltd.:An intervention on the free will debate' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

What is the place of man in nature? How do our everyday conceptions of ourselves and the things around us connect with a scientific picture of the world? These questions loom large in the background of the free will debate. We understand ourselves as free agents facing an open future – but is this a tenable picture vis-à-vis scientific findings? Conceptual as well as empirical neuroscientific arguments have recently led to a heated debate on free will that has reached well beyond the academic sphere.My research line will approach this debate from a theoretical perspective, using results from philosophical logic, metaphysics, and philosophy of science. From that perspective, the main blind spots of the free will debate concern the notions of determinism vs. indeterminism and intervention. Despite its acknowledged centrality for the debate, the notion of indeterminism is insufficiently developed; my research will show how a notion of limited indeterminism can help to dispel many worries about the role of an open future for free will. The notion of intervention, which is prominent in research on causality, is almost completely absent from the free will debate; my research will fill this lacuna. Overall, my aim is to lay the conceptual foundations for and work out the details of a novel, rich notion of indeterminism-based free will.Three sub-projects involving the PI, two post-doc researchers and a Ph.D. candidate will work towards this aim in a modular fashion. Besides contributing to the philosophical free will debate and its broader public ramifications, my research line will interact with neuroscientific research and will open up prospects for future research in theoretical and in practical philosophy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ADAPTIve player-centric serious video gaMES' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The ADAPTIMES (ADAPTIve player-centric serious video gaMES) project aims at investigating how cognitive abilities, psycho-emotional processes and playing style can be used as a basis for efficient and effective player-centric adaptivity in serious games. For understanding how these three mental characteristics of the player are related to game adaptivity, the project will use a novel combination of methods and techniques. Cognitive abilities and processes will be tracked while player performs creative and challenging tasks requiring both divergent thinking (for finding various possible solutions) and convergent thinking (for choosing the best solution), and also measured by psychometric tests. On other side, psycho-emotional status and processes and playing style are going to be accessed by means of non-intrusive behavioral measuring techniques like 3D eye tracking, gestures and interaction patterns, and navigation control. Research findings are expected to address behavioral patterns and correlation between these mental characteristics and will be used for creation of an adaptation control framework using the video engine of Brainstorm S.A. (host institution). The framework will be integrated in serious video games targeted to one of the most promising educational areas - that of entrepreneurial education. Video games are chosen due to their immersiveness, attractiveness and visual effects useful for presenting tasks requiring entrepreneurial creativity. Via a field trial of playing the game by students in entrepreneurship, the project will validate the expected efficiency of adaptation control based on the mental characteristics of the player. Thus, the project plans to produce multidisciplinary and inter-sectoral results which will contribute to European competitiven
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Construction and investigation of quantum history theories' (1994-1998).

assistant: **Concept**

Research objectives and content Field: Mathematical Physics ! Isham's history quantum theories are a novel mathematical and conceptual framework for the formulation of quantum theories in physics. There is the substantiated hope that Isham's programme could provide a framework for solving certain technical and structural problems arising in quantum gravity. The purpose of the suggested work is the investigation of the mathematical and conceptual structure of such theories and to formulate explicitly a physically nontrivial example in quantum field theory or quantum gravity. Particularly, the decoherence function for quantum field theoretical systems has to be investigated. The research should give essentially new information about the physical meaning of the concepts of quantum theory itself and about the possibilities to reconcile quantum (field) theory with the principles of special and general relativity. Training content (objective, benefit and expected impact) The Imperial College offers a wide range of opportunities for training and research in the fields of quantum field theory, cosmology, and gravity. Training in the newest developments in these fields is indispensable for the proposed research project. Moreover, in Isham's group one can learn about history theories 'from first hand.' It is thus to be expected that the training opportunities at Imperial College will highly stimulate the work on the proposed research project. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Designer superconductivity in interacting quantum metamaterials' in the context of a Horizon 2020 call.

assistant: **Objectives**

Despite intense research activity, most new superconductors are discovered by chance, rather than by deliberate design. Consequently, they have limited tunability, which has plagued progress towards a room-temperature demonstration. In particular, electron interactions are extremely challenging to tune, but are assumed to be vital in most high-temperature superconductors. Here I introduce a new paradigm for the bottom-up fabrication of custom-designed superconductors, called interacting quantum metamaterials. These metamaterials are precisely constructed, one atom at a time, using a scanning tunneling microscope. They inherit tunable, strong electron interactions from their unique substrate: a topological Kondo insulator (TKI). A TKI substrate neatly overcomes the two impediments for interacting quantum metamaterials: it hosts quasiparticles that move slow enough to interact with one another, and it is a true topological bulk insulator, which electrically confines these quasiparticles to the surface, where they are easily accessed and manipulated.  By rearranging surface atoms, I will create metamaterial geometries that localize these novel TKI surface quasiparticles in order to mimic the parent state of many high-temperature superconductors, a Mott-like insulator.  Then, I will adjust the electron concentration by tip-induced electrostatic gating and behold the onset of superconductivity in a fully tunable experimental platform. These results will open a new path to room-temperature superconductors, leading to highly efficient power transmission and storage, which can reduce CO2 emissions and slow climate change.


**Keywords:** Topological Kondo insulator, atom manipulation, metamaterials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Low Energy Conference' in the context of a Fifth Framework call.

assistant: **Objectives**

In the countries of the European Unio more than one third of the construction activities are in there furbishment of existing buildings. The consciousness of the people of the refurbishment of existing building stock will increase if economic and environmental advantages are explained and demonstrated. The benefits that will be gained are more evident, e.g. comfort, health, enjoyment, capital value, reduced running and maintenance costs as well as safeguard to the fluctuation in the energy price. The refurbishment and re-use of existing building is more sustainable than to demolish and construction of new ones. The refurbishment generates employment in the building industry. Culturally it is beneficial to renovate buildings of historical value, preserve and enhance the landmark in cities, towns and villages. A lot could be learnt from the refurbishment and it could and should be used in the design and implementation of new buildings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The genomic impact of ancient structural variants on species extinction' (GENOMICIDE).

assistant: **Concept**

In this proposal, I seek to quantify the impact of structural variants on species genome diversity and extinction by sequencing ancient genomes of extinct megafauna. Structural variants are large genomic rearrangements capable of significantly affecting gene function and fitness. While in previous work I have investigated the genomes of extinct species at the single nucleotide polymorphism (SNP) level, the accurate identification of structural variants has been hampered by molecular and computational challenges, thus impeding their incorporation into genomic extinction research. Recent advancements in long-read sequencing technologies have led to considerable improvements in accuracy and affordability, making it feasible to characterize structural variants at population level scale in non-model organisms. Despite the fragmented nature of ancient DNA, our preliminary results show that millions of ancient DNA sequences exceeding 500 basepairs in length can be obtained from extraordinarily well-preserved samples. This project capitalizes on these samples, combined with state-of-the-art sequencing technologies, to recover high-quality long-read sequencing data from ancient specimens and subsequently reconstruct extinct genomes de-novo. Focussing on megafaunal that went extinct during the late Pleistocene, this project will examine the evolution of structural variants under scenarios of increased genetic drift and reduced selection at unprecedent resolution. Moreover, the project will pioneer the direct quantification of within-species structural variant changes through time, and provide new insights into genetic variants within previously unassembled genomic segments. By expanding our understanding of the genetic role of structural variants on extinction events, we will con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of endogenous opioids in the pathophysiology of drug dependence and nociception. Possible therapeutic application of new enkephalin catabolism inhibitors' in the context of a Fourth Framework call.

assistant: **Objectives**

In this programme, we harmonize the chemical, molecular, biochemical, pharmacological and clinical methodologies of different European teams to investigate basic mechanisms and therapeutic alternatives of drug dependence and nociception. In the first phase, we will investigate the role of the endogenous opioid system and their intracellular messengers in the pathophysiology of drug dependence and associated disorders. Two essential tools will be available to deal this objective: the mutant mice deficient in some proteins related to the intracellular response of the opioids (generated by partner 3) and the new inhibitors of enkephalin catabolism (synthesized by partners 4 and S). Mutant mice will be used to investigate the specific involvement in the development of these neurological disorders of cAMP-dependent pathway and gene expression. The different mutants now available and the generation of brain specific and inducible mutation for these proteins will allow penetrating deeper in the role of these intracellular messengers linked to the opioid system. A multidisciplinary approach (behavioural, partnerl; biochemical, partner 6; molecular, partner 3) will be used in this research.The inhibitors of enkephalin catabolism recently design by partner 5 (RB 1000)represent an useful tool to complement the study at these neurological mechanisms. These inhibitors have a major advantage in comparison with previous compounds, e.g., they are active after oral administration. This improvement in the pharmacokinetic properties is a decisive step forward for evaluating their therapeutic perspectives. The results already obtained with RB 1000 in animals suggest promising therapeutic applications on pain relief and heroin addiction treatment. In a second phase, we propose to further ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Polymeric biomaterials : from nanogels to macroscopic networks' to be submitted under Fifth Framework.

assistant: **Abstract**

Hydro gels, i.e. materials containing cross-linked polymer network swollen by water, are of significant importance in various areas of biomedicine and pharmacy. Studies carried out in our group focus mainly on the radiation synthesis and properties of the above-mentioned products with regard to their potential application as wound dressings, drug delivery systems, elements of implants, etc. Recently, the main area of our research concerns stimuli-sensitive macroscopic hydro gels and, especially, a new class of materials so-called nanogels i.e. intramolecularly cross-linked polymer chains. Rapid progress in these fields of material science allows us to include these systems in the list of the materials of XXI century". We offer the possibility of working in young team of scientists with research profiles including the knowledge of radiation techniques and processing, but also on the chemistry and physicochemistry of polymer solution. Our research resources comprise of irradiation facilities, as well as modem equipment for polymer analysis and characterisation (e. g. static and dynamic light scattering set-up, rheometer, viscometers, gel permeation chromatography equipment, etc.). Young researchers will receive broad training in the field of synthetic, analytic and materials aspects of polymer science and will become acquainted with radiation techniques and polymer material analysis.This goal will be achieved additionally by formal and informal interactions, meetings and presentations. We are looking for the persons with the background in chemistry and polymer/material science preparing their Ph. D. on hydro gels, stimuli-sensitive polymers and their networks, biomedical polymers and/or polymeric nanomaterials."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Empowering Personalized Therapeutics: Advancing 3D-Nano DLD Arrays and Raman Micro-Biochips for Precision Isolation, Segmentation, and Molecular Profiling of Exosomal Trop2 Biomarkers in TNBC' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The ExoDiagAI project is at the forefront of addressing a critical challenge in modern healthcare—early diagnosis and effective management of breast cancer, particularly the aggressive and elusive triple-negative breast cancer (TNBC) subtype. TNBC lacks well-defined molecular targets, hindering treatment options. Exosomes, a subset of extracellular vesicles with unique functions, hold great promise as diagnostic and prognostic markers for various diseases, including cancer. These tiny vesicles are abundant in biological fluids but have been underutilized due to the absence of a cost-effective isolation protocol. Our primary goal is to develop a microfluidic device, integrating nano-lateral displacement arrays with a Raman biochip, to identify exosome biomarkers specific to TNBC and translate this knowledge into clinical practice. This project's main objectives encompass creating the microfluidic device, assessing its surface-enhanced Raman spectroscopy (SERS) capabilities, conducting Raman fingerprinting of exosomes from in vitro cell cultures and patient samples, and employing chemometric analysis to discriminate biomarkers. The distinctive Raman fingerprinting associated with exosomes serves as a promising prognostic and diagnostic marker. By introducing 3D printing SERS technology, we aim to enable real-time monitoring, shedding light on exosome structural integrity. This interdisciplinary project combines organic, inorganic, nano, computational, spectroscopic, and molecular biology techniques, culminating in innovative device fabrication. Ultimately, the ExoDiagAI project holds the potential to revolutionize early breast cancer diagnosis through exosomal biomarkers, aligning with the EU's sustainable development strategy for advanced diagnostic platforms and fosteri