RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Anti-tick Vaccines to Prevent Tick-borne Diseases in Europe'.

assistant: **Concept**

Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against selected tick proteins can lead to decreased pathogen transmission by inhibiting tick feeding - known as ‘tick immunity’ - or by neutralizing tick proteins that facilitate the transmission of tick-borne pathogens (TBPs). Also humans with hypersensitivity to tick-bites have a lower risk of contracting tick-borne diseases (TBDs). Therefore, anti-tick vaccines encompass an innovative strategy to prevent TBDs in humans, or animals and wildlife to indirectly reduce the risk of contracting TBDs for humans.Overall Objective To identify and characterize tick proteins involved in ‘tick immunity’ and TBP transmission and to use this knowledge to develop anti-tick vaccines to prevent multiple human TBDs.Methods Using state of the art proteomic and transcriptomic approaches we will identify and characterize novel tick salivary gland proteins, which will be subsequently assessed as anti-tick vaccines to protect against LB, babesiosis and TBE in animal models. In addition, through an integrated and multidisciplinary approach involving CEE public health institutes, health organizations and industrial companies we will examine how to develop anti-tick vaccines and implement these in public health systems.Impact ANTIDotE will deliver 1) essential knowledge on the biological mechanisms involved in the pathogenesis of TBDs, 2) proof of concept of an anti-tick vaccine protecting against multiple h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Automated Trade Execution Engine for Power Markets' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In this project, we are going to develop Automated Trade Execution Engine for intra-day power markets. When developed, it will provide fast, cheap and reliable market access to small renewable generators, independent suppliers and trading companies without the need for a costly intra-day trading team that operates 24/7/365. The solution is self-learning meaning that it can iterate over years and years of market data to induce the best trade execution strategies. It is significantly faster than manual traders - it can react to market changes in milliseconds, and therefore, it significantly outperforms manual trade execution. It is extremely scalable - the same software solution can be used across most European markets without the standard proportional increase in costs. Automatic trade execution is already flourishing in financial markets with 85% of trades being executed automatically in contrast to 0% in power markets and the aim of this project is to unlock the value in this multibillion market opportunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Gauge/gravity duality and its applications to condensed matter physics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The gauge/gravity duality conjecture asserts an equivalence between theories of gravity on a curved space and ordinary quantum field theories defined on the boundary of such spaces. This duality has become a powerful tool to study strongly interacting systems by use of a conjectured dual weakly coupled string/gravitational theory, allowing new computations that go beyond the standard perturbative techniques of quantum field theories. The proposed projects focus on applying the gauge/gravity duality to more realistic condensed matter systems. In particular,  the following topics will be studied: a) Constructing black hole solutions with anisotropy and studying their thermodynamics and transport coefficients; b) Constructing black hole solutions in four-dimensional higher derivative gravity and realizing the Coleman-Mermin-Wagner theorem; c) Modeling the holographic superconductor/insulator phase transition with inhomogeneity. The proposed projects will deepen our understanding on gauge/gravity duality itself and will provide a more precise description on realistic condensed matter systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'High-speed all electric bio-cantilever'.

assistant: **Objectives**

Advances in micro-, nano-, and biotechnology put increasing demands on nanoscale microscopy and characterization. Atomic force microscopy (AFM) is one of the highest resolution microscopy methods used in this area. In this project, we will develop a new type of AFM sensor, which will significantly increase the performance of AFM and make it suitable for a much broader range of applications, especially in the life sciences. While traditional AFMs using optical detection of the cantilever sensor, yield very high resolution images, their imaging speed is low, they are difficult to automate and integration with other analysis techniques is limited due to the required optical components.This project aims at removing these limitations for a large area of attractive AFM-applications such as fast analysis in materials science and biological applications. The innovative concept is based on ""all electric bio cantilevers"", ALBICAN. These cantilevers will use novel granular tunneling resistors (NTR), which are fabricated with a mask-less direct writing technique: focused electron beam induced deposited (FEBID). The AFM cantilever will be equipped with an NTR deflection sensor that directly measures the cantilever signal electrically, which removes the need for optical cantilever detection. Recent improvements in AFM cantilever technology have increased the imaging speed of AFM by up to two orders of magnitude by miniaturizing AFM cantilevers (SCL-Sensor.Tech., AMG-T).  The unique approach in this proposal, which builds on new materials and fabrication processes (Nanoss), will allow the manufacturing of unprecedented small cantilever sensors with vastly superior performance in imaging speed and usability. These cantilevers will be compatible with a wide variety of existing AFMs an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Drug repurposing for inhibiting pathogenic biofilms and potentiating the activity of antibiotics' under Horizon 2020.

assistant: **Concept**

Bacterial biofilms are closely associated with chronic infections, leading to much higher tolerance to antibiotics and treatment failures. New strategies for biofilm disruption are thus urgently required. Cyclic-di-GMP, a secondary messenger promoting biofilm formation, is a promising drug target. Only few compounds that reduce c-di-GMP levels and inhibit biofilms were identified so far, and most studies were conducted in vitro using standard medium and reference strains. In this project drugs will be repurposed for targeting c-di-GMP and biofilms to increase the antibiotic susceptibility of clinical Pseudomonas aeruginosa strains. Interdisciplinary approaches will be applied, combining next generation sequencing, gene expression pattern in synthetic sputum, protein structural modelling and computational drug docking, lung epithelial cell infection and murine model. This project will increase the accuracy of drug discovery based on c-di-GMP and significantly expand the skillset of an early career researcher with a strong background in the molecular mechanism of c-di-GMP pathway. The new knowledge in human cell culture and murine model obtained in this fellowship will be crucial for the researcher with a long-term interest in infection treatment. The host laboratory at Ghent University (UGent), a leading group in Europe investigating combination therapy against biofilms, offers an excellent atmosphere fostering both technical and transferable skills. The researcher will also benefit from the supervisor’s extensive research network and the numerous training programs provided by UGent to enhance the future career prospects. The research outputs will provide fresh insights into how genetic and environmental conditions influence c-di-GMP pathway (basic science) and how to se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Reconstructing the History of Lunar Volatiles' (RESOLVE), addressing dissemination and exploitation.

assistant: **Impact**

One of the most exciting recent discoveries in the field of Planetary Sciences has been the confirmation of the presence of water and other associated volatiles in the Moon. These findings have come via laboratory measurements of returned lunar samples exploiting the latest advancements in analytical instrumentation and in-situ techniques, such as secondary ion mass spectrometry (SIMS). Not only has the latest research revolutionized our understanding of the abundance and distribution of volatiles on the lunar surface and in the lunar interior, but it has also highlighted potential roles of their different sources and processes imparting specific isotopic signatures to lunar volatiles.RESOLVE aims at understanding how the abundance and the distribution of volatile components, as well as their isotopic composition are influenced by the crystal structure of the host mineral. The volatile-bearing minerals – primarily phosphates – respond to pressure increase caused by an impact event through modification of their crystal structures, resulting in not only redistribution of the volatile elements (e.g., H, Cl, F), but also of the stable (e.g., H, D, 37Cl) and radiogenic (e.g., 207Pb) isotopes. Therefore, phosphate minerals have the extraordinary potential to simultaneously provide an opportunity for precise age-determination of an impact event, as well as to track any associated modification in the indigenous isotopic signatures of their volatile components. Once we better understand the crystal-chemical-isotopic behaviour of lunar volatiles by a multi-analytical approach combining in-situ elemental, stable and radiogenic isotope geochemistry with structural characterization, we can then begin to discriminate between different sources (solar wind, cosmic radiation, etc.) of w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Avion de recherche atmosphérique et de télédétection fokker' to be submitted under Fifth Framework.

assistant: **Abstract**

Description:ARAT is a versatile flying laboratory offering several scientific configurations: basic meteorological instrumentation, turbulent flux equipment, in-situ and remote sensing chemistry instruments (NO-NOx-NOy, NMHC, Water Vapor and Ozone Lidars), Aerosol Lidar, Earth Observation Instrumentation (Visible, Microwave, POLDER). Access to the ARAT is offered through the EC-funded Human Potential Programme - Access to Research Infrastructure contract, under a joint aircraft project (with DLR, Germany; MRF, UK; and Meteo-France, France) called CAATER (Co-ordinated Access to Aircraft for Transnational Environmental Research). About 9 hours on ARAT is foreseen per user group, for a total of 6 research user groups from EU Member or Associate States. The facility is offered with the configuration required, including infrastructural, logistical, technical and scientific support.Application:How to Apply for Access: Through call for proposals, as advertised in various scientific literature, including 12-monthly through the Newsletter of the European Geophysical Society, and via the internet the address below. Selection of proposals is carried out by the CAATER User Selection Panel, involving 7 external experts, to ensure an independent peer review. Selection will be on the basis of scientific merit, taking into account the interests of the Community.Project Manager:Sylvie Joussaume, Centre National de la Recherche Scientifique, 3 - 5 rue Michel-Ange, Paris Cedex 1675766, B.P. 287, FranceTel: +33-1-44964380Fax: +33-1-44965350E-Mail: sylvie.jouissaume@cnrs-dir.fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Functional characterization of products homologous to fission yeast multi-drug resistance determinants' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content Pohl (Padl human homologue) is a novel and highly conserved component of the human 26S proteosome that confers resistance to some chemotherapic drugs when overexpressed in mammalian cells, as the homologue of fission yeast Padl (V. Spataro et al. J. Biol. Chem.. 272, 30470-30475,1997). We aim to study the significance of Pohl in human tumour cell multi-drug resistance by exploting the NCI panel of 6( tumour cell lines. In order to investigate the mechanism of drug resistance in more detail, expression of Pohl at different levels, by a regulatable expression system, will be carried out in a selected tumour cell line. Furthermore, in order to define the normal physiological role of Pohl I, its expression and activity will be analysed after exposure of the cells to some stresses, such as drug exposure and hypoxia. Crml is a second determinant of multi-drug resistance, conserved from yeast to human: whose function i! involved in nuclear export...Defect in this process could be relevant for tumour progression, since human Crml interacts with the potential oncogenic nucleosporin, encoded by CAN gene. We propose to use yeas genetics in order to identify mutant drugs resistance-inducing alleles of hCRM I, and to perform immunochemical analysis of hCRM I expression. Training content (objective, benefit and expected impact) The aim is to achieve a better and comprehensive understanding of the extent and nature of involvement a these new genes in human tumour drug resistance pathways in order to pave the way for a more efffective cancer therapy. Links with industry / industrial relevance (22) By discovering new drugs able to block the uncontrolled growth in cancer cells, they could have a potential at commercial level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Deep micropatterning of gaas sensor arrays by wet chemical etching' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The knowledge to be transferred is the know-how of development and implementation of technology micropatteming of GaAs substrates by wet chemical etching. For the etching experiments detailed knowledge in using photolithography shall be applied. After patterning a suitable procedure of passivation is needed. The applicant has to design the masks, to evaluate the optimum experimental parameters for etching and passivation, to choose the best composition of etchant, capping layer material etc. Furthermore, the detailed knowledge of the applicant how to characterize micropatterned Semiconductor substrates and layers before and after passivation by several microscopy and scanning probe techniques, particularly by scanning electron microscopy and atomic force microscopy in order to determine the aspect ratio, shape of groove, surface roughness, degree and homogeneity of filling of groove etc. Finally, the experience of the applicant in discussion how to apply patterned compound semiconductor substrates in devices, e. g. as active element of sensor arrays shall be used. The purpose of the project is to fabricate and test deep periodical micro pattern on semi-insulating GaAs substrates that are under discussion for application as sensor arrays for detection of high-energy X-rays used for imaging techniques with high spatial resolution as radiography and tomography. The micro pattern is a net of grooves of high aspect ratio (depth <= 100 µm, width <= than 5). These grooves shall reduce the effect of blurring in sensor arrays based on GaAs under discussion for the detection of high-energy X-rays and hence improve the spatial resolution. The project applied for shall make a definite contribution to establish the host institution as center for NDT and sensor development in Saxony.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Relativistic Spin Hydrodynamics: Theory and Applications' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This proposal establishes connections between fluid dynamics, quantum field theory, and mathematical physics to develop new tools to better characterise out-of-equilibrium properties of relativistic quantum many-body systems. My work is instrumental to understand the emergence of novel fluid-like behaviours which are not apparent in the fundamental laws. The focus of my research is the quark-gluon plasma (QGP), an exotic phase of quantum chromodynamics (QCD) where quarks and gluons are not confined inside of nucleons. The QGP is formed in relativistic heavy-ion collisions performed at the Large Hadron Collider (LHC) and the Relativistic Heavy Ion Collider (RHIC). A huge surprise was the discovery that the QGP behaves as a relativistic liquid with very special properties, namely, it flows with the lowest specific viscosity of any known liquid, and it is by far the system with the largest vorticity ever observed. Such large vorticity triggers particle polarisation, which is a phenomenon resembling the magnetisation displayed by a ferromagnet that is spinning around an axis. This effect shows the interplay between a macroscopic quantity, the fluid rotation, and a microscopic quantity, which is inherently of quantum nature: the spin of the particles. The recent observation of polarisation phenomena of hadrons emitted from the rotating QGP in heavy-ion collisions calls for a new formulation of relativistic fluids where spin degrees of freedom are crucial to the dynamics -- this is called relativistic spin hydrodynamics. Despite fluid dynamics being an old subject, the formulation of the full causal and stable theory of relativistic spin hydrodynamics which can be used for theoretical predictions is yet to be developed.Expected outcomes from this proposal include:* the formul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovation for Digital Fabrication' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Most products are produced by means of the established mass production infrastructure. Traditionally, this involves large stocks, high manual labor, large capital investments, high energy use, long distance transportation. Although many advanced new materials have unique functional properties that hold a great promise for innovation, they often need to meet the criteria and characteristics of this established mass production paradigm. This delays the exploitation of the huge potential of whole new classes of materials. Combined with major societal trends and consumer needs like customization, personalization, on-demand fulfillment and the fact that the world is becoming ever more digital and networked, there is a need for a paradigm shift in manufacturing called Digital Fabrication.**Digital Fabrication can be defined as a new kind of industry that uses computer-controlled tools and processes to transform digital designs and materials directly into useful products.**DIGINOVA will establish the current status across material domains and application domains in Europe in order to identify the most promising technology and business propositions for Digital Fabrication. The project consortium, consisting of 4 large companies, 7 SMEs and 9 research institutes will identify and connect main stakeholders through establishment of innovation networks centred around concrete business cases to determine the added value and feasible routes to commercialization.The DIGINOVA consortium has broad research and development experience covering a wide range of materials and applications. The consortium is well equipped to generate international interest and expanding participation in the opportunities it identifies and has a proven track record in drafting roadmaps, establishing networks,