RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intensive training course for the development of skills necessary for the succesful participation in Sixth Framework Programme' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The intensive training course EUROPRAXIS is proposed to improve the skills of Latvian stakeholders for a successful participation in Sixth Framework Programme (FP6) and further involvement in European Research Area. The training course is intended to wide spectrum of audience (scientists and entrepreneurs from various thematic fields, representatives from public organizations, policy makers, co-ordinators of National Contact point (NCP), etc.). Experience from FP5 shows that stakeholders from Latvia are informed about FP activities and they have actively taken part in the submission of projects. However, only in rare cases Latvian participants have taken the role of coordinators of the projects. These skills come with experience and practical trainings. Intensive training course EUROPRAXIS will be led by well-known and experienced lecturer Dr.Sean McCarthy. The training course will cover issues on 1) writing a competitive proposal for FP6 and 2) negotiations, management and administration of FP6 contracts. Before training course the identification of audience needs will be carried out, that will render the course very targeted and focussed on the issues especially important for stakeholders. The meeting and communication of participants from different areas during the training course will promote their relationships and foster further collaboration. Such consolidation ensures the especially necessary many-sided approach to issues solved in the FP projects.After the training course the feedback information from audience will be collected and analysed. It will give essential data to NCP for the awareness the issues to which special attention should be paid in the further work.All this complex foreseen in EUROPRAXIS will improve the readiness of Latvian stakeholders for th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Blood-brain barrier: from molecular mechanisms to intervention strategies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Brain endothelial cells (ECs) are endowed with a set of molecular and metabolic adaptations that stringently orchestrate the molecular and cellular transit between the brain and the circulatory system. These adaptations constitute the blood-brain barrier (BBB) and are pivotal to brain homeostasis and protection. Accordingly, BBB dysfunction is a unifying hallmark of many cerebrovascular diseases, including stroke, multiple sclerosis and neurodegeneration. Healing the BBB to treat to the brain is therefore emerging as a powerful therapeutic avenue for a spectrum of human CNS disorders. In addition, through its neuroprotective function, the BBB represents the main obstacle for CNS drug delivery. There is consequently an urgent need to identify methods to control BBB in health and disease. Of pivotal importance, BBB is not genetically hardwired, but instead results from ongoing neurovascular communications taking place between the ECs and the other components of the neurovascular unit. Shedding light on these communications, and raising our understanding to the mechanistic level will undoubtedly yield transformative therapeutic strategies for human brain disorders. A key obstacle in the study of BBB permeability resides in its complex regulation across cells and tissues. This complexity cannot be recapitulated in cell culture experiments. Our laboratory has recently identified and validated the transparent zebrafish as ideally suited to facilitate these studies, by empowering non-invasive genetic analyses of BBB function under normoxia. Together with a conserved BBB genetic instruction program, the zebrafish cerebrovasculature qualifies as a an alternative “miniature BBB model” where neurovascular communication can be studied at an unprecedented pace. Ctrl-BBB will pioneer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synthetic Catch Bonds' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

All primary chemical bonds, covalent and supramolecular, weaken under tension. This imposes fundamental limits on the mechanical stability of molecules and their materials. Nature has evolved to secondary bonds that break through these limits and strengthen under tension. These so-called catch bonds, which know no synthetic equivalent to date, are used in Nature as a rule, rather than exception, in scenarios where supramolecular bonds are exposed to large stresses.   This change in the fundamental mechanical nature of bonds has a profound effect on the mechanics of the materials in which they are integrated. Yet, to date, there have been no systematic studies that establish how the mechanics of individual catch bonds is programmed by their chemical design or how their collective action results in enhanced mechanics of their materials. As a result, our understanding of the ubiquitous use of catch bonds in Nature is incomplete nor do we have clear guides how their potential can be harnessed in creating bio-mimetic soft materials with programmable mechanics.  Project CATCH tackles these challenges by bringing catch bonds to the synthetic domain for the first time. Their de-novo creation gives unprecedented control to establish the design rules for the mechano-activity of single bonds. Moreover, CATCH will systematically explore how the concerted action of many catch bonds within a material lead to material properties that cannot be accessed by any other means, such as the adaptive reduction of strain localisation and the filtering of mechanical signals, which is of crucial importance for mechanical communication between cells in tissue engineering.  Through a multidisciplinary approach that builds on my expertise in synthetic and materials chemistry, single-molecule experi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Peripheral Biomarker Based Combinatorial Early Diagnostics for Dementia' (CombiDiag).

assistant: **Concept**

CombiDiag DN aims to develop an AI-data-driven peripheral biomarker based combinatorial diagnostic protocol for early stages of Alzheimers disease (AD), a major form of dementia, and to train a new generation of fellows for this interdisciplinary field. Dementia, a devastating disease of older age, is the challenge of our lifetime and one of the Societal Challenges listed by the UN Sustainable Development Goals and Horizon Europe. CombiDiag responds to this challenge to establish a much-needed DN to carry out an integrated study of minimally invasive and cost-effective peripheral biomarkers, including body fluid markers from blood, urine and saliva, and digital markers from speech, motor functions and sleep for developing the combinatorial early AD diagnostics. The consortium comprises nine academic and eight non-academic institutions across Europe, USA, Canada, and China. It synergises leading academic and industrial experts worldwide to build a triple-i research and training platform for the training of a new generation of Fellows to take early AD diagnostic research to a new level. Fellows will be trained under the Vitae Researcher Development Framework innovatively combined with the CombiDiag platform for triple-i scientific and transferable skills as well as personal quality, creative thinking, and business mind-set. The DN has a highly innovative research programme for the discovery of peripheral AD biomarkers, detection techniques, AI/data driven technology, clinical validation, and integration into trial designs. The advances in CombiDiag research will enable a case finding tool at primary care level for helping achieve improved drug discoveries, disease-modifying treatments, preventive strategies and care provision for AD. CombiDiag will deliver 10 highly-skill
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'From CO2, Water and Sunlight to Valuable Solar Fuels: Tracking Reaction Intermediates in Solar Fuel Generation with Ultrafast Spectroscopy for More Efficient Catalysis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Fundamental understanding of the catalytic chemistry and underlying mechanisms in carbon dioxide (CO2) reduction is an urgent need for efficient solar energy conversion from CO2, water and sunlight to valuable carbon-neutral fuels that urgently need to replace our fossil fuel-based economy of today. This proposal focuses on unraveling the reaction mechanisms of the reduction of CO2 in aqueous photoelectrochemical (PEC) systems in order to allow innovative development of more efficient chemistry for the production of solar fuels based on the understanding of the underlying mechanisms. We propose to study the catalytic cycle of photo-driven CO2 reduction on earth-abundant and non-toxic materials with state-of-the-art transient absorption (TAS) and transient infrared spectroscopy. The combination of these techniques will open up groundbreaking opportunities to monitor reaction intermediates on the relevant timescales of charge transfer to form the reaction product. First, selectivity of the catalyst will be tuned with the deposition of sub-nanometer oxide layers by atomic layer deposition (ALD) – a technique with a precision of down to one atomic monolayer. Then, the selective reactions will be studied in detail by TAS and transient IR spectroscopy. With the outstanding expertise of the host professors Prof. Durrant and Prof. Hamm (secondment) and my broad and profound expertise in photoelectrochemical systems and ALD, this project is expected to have a high success rate despite its challenging nature. With a better understanding of CO2 reduction processes, the design of more efficient catalytic systems will advance this renewable technology and facilitate its scale-up and commercialization. Finally, through this project I will not only expand my technical and scientific s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on '(R) - Evolutionary Catalysis'.

assistant: **Concept**

Catalysis is at the heart of chemical sciences because it is the art of selectively making and breaking chemical bonds. It is for this reason that it has been a major topic in various fundamental research programs in the past, and also it has served as an important innovative technology in industry. The research efforts in the past decades generally resulted in incremental improvements, with occasional new reactions found by serendipity. It is clear that radical new approaches are required to enforce a breakthrough in this area. We would like to use Nature's most powerful concept, evolution, as a source of inspiration to develop (r)evolutionary catalysts.The implementation of the new concepts in industry will be accelerated through the involvement of DSM in this network, one of the leaders in the use of homogeneous catalysis and biocatalysis in fine chemicals production. It is important to train the young researchers in the many aspects of catalysis. This network will provide the ideal environment for this training. The ESR/ER will learn the importance of catalysis in the industrial context and how to implement catalysis in synthetic pathways. They will be trained in high throughput experimentation and the use of sophisticated robots in synthesis, catalysis and analysis.They will be taught the many different types of catalysis, such as homogeneous catalysis, biocatalysis and organocatalysis, and the value of molecular calculations supporting experimental work. It is clear that researchers trained in the above manner and exposed to the new research concepts will tremendously increase their chance of employment in the European chemical or pharmaceutical industry. In addition, they will help these industries to increase their competitiveness, which will allow them to compe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AmplificatioN Free Identification of cancer and viral biomarkers via plasmonic nanoparticles and liquid BIOpsy' (ANFIBIO) targeting Horizon 2020.

assistant: **Abstract**

The detection of circulating disease biomarkers in bodily fluids, also known as liquid biopsy, has taken important strides toward the implementation of personalized medicine. However, it still suffers from low sensitivity and high costs, which render its clinical implementation not practical or affordable. In particular, the identification and quantification of oligonucleotide biomarkers is hampered by the need to employ long- and short-read sequencing tools that are expensive, require highly trained personnel, and are prone to error. Nonetheless, the recent clinical breakthroughs demonstrating the importance of detecting cancerous or viral biomarker to susceptibility, onset, and aggressiveness of the disease, motivate the need for further research that could render their detection simpler, cheaper, and thus more widely available.By leveraging the intrinsic amplification capability of surface enhanced Raman scattering (SERS), in ANFIBIO I will address the issues of low sensitivity and high costs by combining plasmonic nanoparticles synthesized ad hoc to maximize SERS signal amplification with direct SERS sensing and machine learning tools for the rapid analysis of the complex spectral responses obtained by screening bodily fluids for specific target biomarkers. I will focus in particular on prostate cancer (PCa) DNA and influenza A viral (IAV) RNA in blood, urine, and saliva, to quantify and correlate their amounts to those detected in tissues and cells. At completion, the proposed work will deliver a breakthrough sensing technology capable of detecting and quantifying cancerous and viral biomarkers in bodily fluids, with minimal sample pretreatment, no target amplification, and that uses SERS as novel and reliable transduction mechanism with distinct advantages over th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Machine Learning and the Internet of Things for Optimisation of the Last Mile Delivery' under Horizon Europe.

assistant: **Concept**

Scientific advances in recent years have brought to light a series of potentially disruptive technologies in the ICT landscape. They are becoming, and will increasingly become, key enabling technologies for the development of applications and services designed to improve the quality of life of citizens and make processes more efficient. Among these, we can identify some which research has recently focused on with particular attention: Machine Learning and Internet of Things. In this project we propose a combined use of these two technological enablers to solve one of the main issues which all logistics experts have to face: the problem of optimising the last mile delivery (LMD). LMD is a crucial step of the entire delivery process, as it causes bottlenecks and is typically the most costly, problematic and inefficient part. Improving the LMD process in terms of route optimisation using classic approaches is difficult: static algorithms are not suitable, and even heuristic algorithms do not find high-quality solutions, as they do not consider several factors such as unpredictable real-time events which may occur. To address these challenges, a novel hardware/software architecture which exploits real-time vehicles’ positions to continuously improve performances of the routing algorithms is proposed, together with a new IoT-based methodology to automatically/dynamically assign routes to drivers based on the values of a defined “sixth sense”parameter. A ML module will predict the best among a chosen portfolio of different heuristics/metaheuristics algorithms to optimise the route.


**Keywords:** Last mile delivery, route optimisation, vehicle routing problem, VRP, classifiers, logistic supply chain, IoT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Global traffic in illicit cultural objects: developing knowledge for improving interventions in a transnational criminal market' in the context of a Seventh Framework call.

assistant: **Objectives**

The research seeks to push the boundaries of our understanding of, and social and legal responses to, trafficking in illicit cultural objects. The global market in illicit cultural objects is a structure of relatively rich consumers at one end of the supply chain (collectors, dealers, museums) and relatively poor looters at the other end, in source countries characterised by high levels of the 'natural resource' of cultural objects and low levels of policing resource to devote to their protection against looting (i.e. usually illegal excavation) and other forms of theft. While there has been some research into the market, compared to other international criminal markets such as the drugs trade, very little is known about the motives and activities of participants in the international trade in illicit cultural objects, their trading norms and routines, the pricing structures and criminal mark-ups, mechanisms of smuggling used in this market in order to avoid detection at customs and by other law enforcement agencies, etc. Even such apparently simple matters as the relative size of the criminal side of the antiquities trade are not currently known. Structures of international, and domestic national, law and regulation have been established in response to the moral concern the illicit trade raises, rather than being based on an evidence-oriented investigation of the practical elements of the trade mentioned. While some of these regulatory efforts have had modest success, for the most part they have been a failure in stopping the illicit trade, which continues today. This research proposal establishes a multi-method and multi-sited programme of research which aims to gather and analyse all available evidence on the trade, produce new measures of size and illicit activity us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Incompressible Single and Multi-phase SPH with Improved Boundary Treatment' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The objectives of the proposal are to 1) implement a new improved boundary treatment method (refer to as Multiple Boundary Tangent (MBT) developed by PI) to simulation of complex geometries such as flow over an airfoil, and 2) develop an incompressible multiphase SPH (IMSPH) algorithm, and 3) study feasibility of modeling single crystal growth (CG) processes with SPH. In literature, benchmark simulations using previously reported boundary treatments can suffer from particle penetration and may corrupt simulations near solid boundaries. Current SPH boundary treatments do not properly treat curved boundaries in complicated flows. These drawbacks are remedied in MBT. Previously solved benchmark problems using MBT were relatively simple. To understand full power and limitations of MBT, PI plans to solve complex flow problems such as flow over an airfoil and free surface flow. PI’s current incompressible SPH code will be further improved to develop an IMSPH code. In this direction, a novel multiphase projection formulation will be developed to treat sharp changes in transport properties and density. Several benchmark problems will be solved for validation. Resin filling process in polymer composite manufacturing by RTM will be simulated as a multiphase flow. SPH is convenient for simulations involving moving interfacial surfaces such as semiconductor CG. In CG, mesh-dependent methods are difficult to implement, as computational mesh is required to adapt to CG surface. In modeling of ternary alloy crystals, governing equations must be solved simultaneously in liquid and solid phases to resolve growth interface correctly. This requires iterations at liquid/solid interfaces, slowing down simulations notably. In SPH, there is no need for interface iterations; all domains are sol