RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low Regularity Dynamics via Decorated Trees' in the context of a Horizon Europe call.

assistant: **Objectives**

Low regularity dynamics are used for describing various physical and biological phenomena near criticality. The low regularity comes from  singular (random) noise or singular (random) initial value. The first example is Stochastic Partial Differential Equations (SPDEs) used for describing random growing interfaces (KPZ equation) and the dynamic of the euclidean quantum field theory (stochastic quantization). The second concerns dispersive PDEs with random initial data which can be used for understanding wave turbulence.  A recent breakthrough is the resolution of a large class of singular SPDEs through the theory of Regularity Structures invented by Martin Hairer. Such resolution has been possible thanks to the help of decorated trees and their Hopf algebras structures for organising different renormalisation procedures. Decorated trees are used for expanding solutions of these dynamics. The aim of this project is to enlarge the scope  of resolution given by decorated trees and their Hopf algebraic structures. One of the main ideas is to develop algebraic tools by the mean of algebraic deformations. We want to see the  Hopf algebras used for SPDEs as deformation of those used in various fields such as numerical analysis and perturbative quantum field theory. This is crucial to work in interaction with these various fields in order to get the best result for singular SPDEs and dispersive PDEs. We will focus on the following long-term objectives:- Give a notion of existence and uniqueness of quasilinear and dispersive SPDEs. - Derive a general framework for discrete singular SPDEs.-  Develop algebraic structures for singular SPDEs in connection with numerical analysis, perturbative quantum field theory and rough paths.- Use decorated trees for dispersive PDEs with random
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Indicators and data for European analysis' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The project will contribute to advance the state of the art in innovation-oriented science, technology and innovation indicators, particularly as a tool for policy use. This will be done through theoretical, methodological and empirical work involving both existing indicators, and the development of completely new indicators.This project will: - analyse the implications of new theories of innovation and economic change both for policy and for indicators needs; against this background, existing indicators will be critically reviewed, and areas for new indicators will be proposed - develop a Guide for Policymakers which will overview all available science, technology and innovation indicators and provide a sophisticated guide to their modes of use - develop six completely new areas of indicators, focusing on analytical methods and/or survey instruments, aimed at extending the sectoral and functional range of existing and potential indicators, with the specific objective of a substantial improvement in our understanding of the service sector, inter-industry diversity, system interactions, environmental issues, innovation inputs and human resources. The Guide for Policymakers will be a very useful tool for all institutions, at different levels, within the European Union in charge of S&T policy. A final report will lead to a theoretical and methodological examination of the possibilities for new indicators, and the development of appropriate questionnaire design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular mechanisms of autophagosome formation during selective autophagy' (AutoRecon) targeting Horizon 2020.

assistant: **Abstract**

I propose to study how eukaryotic cells generate autophagosomes, organelles bounded by a double membrane. These are formed during autophagy and mediate the degradation of cytoplasmic substances within the lysosomal compartment. Autophagy thereby protects the organism from pathological conditions such as neurodegeneration, cancer and infections. Many core factors required for autophagosome formation have been identified but the order in which they act and their mode of action is still unclear. We will use a combination of biochemical and cell biological approaches to elucidate the choreography and mechanism of these core factors. In particular, we will focus on selective autophagy and determine how the autophagic machinery generates an autophagosome that selectively contains the cargo. To this end we will focus on the cytoplasm-to-vacuole-targeting pathway in S. cerevisiae that mediates the constitutive delivery of the prApe1 enzyme into the vacuole. We will use cargo mimetics or prApe1 complexes in combination with purified autophagy proteins and vesicles to reconstitute the process and so determine which factors are both necessary and sufficient for autophagosome formation, as well as elucidating their mechanism of action.In parallel we will study selective autophagosome formation in human cells. This will reveal common principles and special adaptations. In particular, we will use cell lysates from genome-edited cells in combination with purified autophagy proteins to reconstitute selective autophagosome formation around ubiquitin-positive cargo material. The insights and hypotheses obtained from these reconstituted systems will be validated using cell biological approaches.Taken together, our experiments will allow us to delineate the major steps of autophagosome for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimisation of mould and core quality and materials usage in the metal castings industry' to be submitted under Fifth Framework.

assistant: **Abstract**

The manufacture of cast metal components involves the use of cores to form the inside of shaped parts. These cores can be complex in shape and have to be of accurate dimensions and high quality. The cores are now commonly made by a process which blows sand into a shaped box and the sand is hardened by blowing through a catalyst gas. The manufacture of cores relies on past experience and there is no accurate computer simulation process currently in use. The project aims to develop a computer software programme to simulate sand filling and gassing of cores. This will be applied to the development of the blowing machine and the process extended to production of thin shaped contoured moulds. This will enable core design and manufacture to be improved and reduce time to market, costs and improve quality of casting manufacture.-The partner requirements for the software have been defined and outlined to provide a software package which has an accuracy and operational time base to suit the industry in a practical way, i.e. not purely theoretical but giving indications of problem areas within the core blowing operation.-A Laempe 10 litre core blower was specified, built, delivered, and made operational within the second and third quarters of the project. The machine was equipped to operate using the CO2 cured Novanol sand system supplied by Ashland.-Visualiation techniques have been developed and shown to operate with three sand systems, viz. Novanol, Cold Box (amine) and Betaset. These visualisation techniques have used the test component designs and a range of real time and rapid recording methods to show the progress of sand when blown into a core box with different configurations of shape and venting type and position. Similarly methods have been developed which show the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ETIPWind- Aligning Wind Energy Research and Innovation Strategies' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The overall objective of the ETIPWind project is to continue and enhance the activities and deliverables of the current ETIPWind. The project will bring together key stakeholders of the wind energy sector (industry and academia) and the broader energy sector to assess challenges and articulate common Research & Innovation priorities. The ETIPWind project aims to inform the European Commission's SET-Plan and the Research & Innovation implementation plan on EU's Research & Innovation policy to sustain Europe's global competitive edge in wind energy and deliver on the EU's Climate and Energy targets cost-effectively.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative Icebreaking Concepts for Winter Navigation' in the context of a Seventh Framework call.

assistant: **Objectives**

The ice cover of the Baltic Sea Motorway varies considerably from year to year. The northern parts  freeze every winter. In a hard ice winter it freezes completely. Despite climate change, hard ice winters occasionally occur in the Baltic Sea.Even the current icebreaker fleet available in the Baltic Sea is incapable of providing a satisfactory level of service in a hard ice winter. The combination of growing traffic volumes and hard ice winter will mean serious difficulties for industrial and commercial transports.Some of the current icebreaker fleet will reach the end of its lifespan in the 2010s. It is evident that replacement investments will not yield a satisfactory level of service in hard ice winter conditions. Considering the growing traffic volumes, a satisfactory level cannot be reached even in an average ice winter. A large oil tanker, for instance, requires simultaneous assistance from two traditional icebreakers that together are capable of breaking a sufficiently wide channel through the ice.The objective of the proposal is to find out what benefits can be attained in the level of service of icebreaking assistance, in logistics and especially in oil transports, and with regard to environ-mental emissions and risks, bya) adopting the new technical solutions, and/orb) utilising the new type of agreement systemThe new technical solutions may be the innovations that are alone capable of breaking a suffi-cient wide channel also for overwide merchant vessels, e.g. oil tankers. The technical solutions have already completed but not introduced.The new agreement system to be developed would be based on the utilization of icebreaking capability of independently ice-going merchant vessels. It is important that jointly accepted rules could be enforced for cases where t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Space-Time and Vectorial Meta-Optics for High-Power Structured Laser-Matter Interactions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Plasma is an extreme form of matter at the heart of important applications like fusion and particle acceleration. The creation and control of plasma require high-power lasers, now increasingly within reach, often operating at terawatt or petawatt levels. One of the six grand challenges in Plasma Science and Engineering is mastering the art of molding plasmas with lasers, yet a gap exists: the need for advanced beam control at high power levels.metaPOWER aims to fill this gap by developing high-damage-threshold metasurfaces—the state-of-the-art nanotechnology in structured light—for high-power lasers. These metasurfaces will be integrated in innovative laser beam shapers, offering spatiotemporal and vectorial (polarization) control over laser beams, thus making a leap over the state of the art, which is currently limited by the lack of advanced high-power optics.The project will demonstrate the ability to seed and control laser-plasma instabilities via reconfigurable vector beams, and to create topology-controlled wakefield acceleration and tunable X-ray and THz-to-xUV sources based on space-time beams with orbiting pulses. This marks a paradigm shift in laser-matter interactions, enabling new possibilities in fusion energy, particle acceleration, and radiation sources. Feasibility is backed by solid preliminary results, including successful structured laser-plasma simulations, a demonstrated scheme for the synthesis of space-time beams, and initial metasurface fabrication resilient to high-power lasers.The implications of metaPOWER's success extend far beyond the groundbreaking objectives of this proposal. These transformative technologies may catalyze advancements in quantum plasmas, laser material processing, high harmonic generation, and the development of a new clas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrated oral drug delivery system' in the context of a Sixth Framework call.

assistant: **Objectives**

Sigmoid Biotechnologies, an Irish Drug Delivery Systems Development SME established in 2003, has developed a novel oral controlled release technology, Liquid and Emulsion Drug Delivery System or LEDDS. LEDDS enables the controlled release of difficult to formulate drugs that are optimally formulated in various liquid or emulsion formats. To date, Sigmoid has demonstrated that LEDDS is effective in delivering small molecule as well as cyclic peptide drugs.Going forward, Sigmoid has recognised that a modified LEDDS format would have significant potential to orally delivery biopharmaceutical drugs such as peptides and proteins. The LEDDS modification will require that Sigmoid strengthens its knowledge of lipid and emulsion formulation technologies, bioadhesive polymer synthesis and development as well as establishing an in-house intelligent in vitro drug formulation screening technology. To facilitate this development, a multidisciplinary work programme has been planned and will involve Sigmoid collaborating with and transferring personnel amongst four EU laboratories based in Poland, Italy, Germany and Ireland, each recognised as world class in their respective fields.Developing an integrated LEDDS-enabled oral biopharmaceutical delivery system will lead to the development of significant patent protection and increase Sigmoid's competitive position in the drug delivery industry in general and in the area of biopharmaceutical delivery in particular. Sigmoid's partners will benefit from acquiring knowledge of LEDDS technology as well as industrial training in a cGMP facility. Also, visiting scientists will have opportunities to publish and present the work carried out as well as being encouraged to file patents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Monitoring Developments for safe Repository operation and staged closure' in the context of a Seventh Framework call.

assistant: **Objectives**

The MoDeRn project aims at providing a reference framework for the development and possible implementation of monitoring activities and associated stakeholder engagement during relevant phases of the radioactive waste disposal process, i.e. during site characterisation, construction, operation and staged closure, as well as a post-closure institutional control phase. Monitoring provides operators and other stakeholders with in-situ data on repository evolutions, to contribute to operational safety, to help manage construction, operation and/or closure activities, and may allow for a comparison with prior safety assessments. It thus provides information to inform necessary decisions. If, in addition, monitoring activities respond to stakeholder needs and provide them with understandable results, they will contribute to transparency and possibly to stakeholder confidence in the disposal process. The project is structured into six work packages (WPs). The first four WPs are dedicated to (i) analyze key objectives and propose viable strategies, based on both technical and stakeholder considerations; to (ii) establish the state of the art and provide technical developments to match specific repository requirements; to (iii) conduct in-situ monitoring demonstration experiments using innovative techniques; and to (iv) conduct a case study of monitoring and its integration into staged disposal, including specific scenarii analysis aimed at providing guidance on how to handle and communicate monitoring results, in particular when these provide “unexpected” information. In order to provide a shared international view on how monitoring can be developed within a given national context, WP5 regroups key dissemination activities and WP6 will provide a reference framework integrating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantitative network-level analysis of stochastic cell fate decisions' (STOCHCELLFATE), addressing dissemination and exploitation.

assistant: **Impact**

In a developing embryo, each cell has to assume the correct cell fate to yield a viable adult organism. It has become clear that the signaling networks that control development are heavily influenced by molecular noise, i.e. stochastic fluctuations on the molecular level. Intriguingly, in many organisms cell fates are assigned in a stochastic manner. Such stochastic cell fate decisions are thought to exploit molecular noise, using positive feedback loops to amplify noise into an all-or-nothing cell fate decision. Yet, how a stochastic process results in robust cell fate assignment without errors is poorly understood.To address this question, we propose to study stochastic cell fate decisions in the nematode C. elegans using a new quantitative, physics-inspired approach. To this end we will use two innovative techniques to quantify the stochastic dynamics of the signaling networks controlling the cell fate decisions. First, we will use single molecule Fluorescence In Situ Hybridization to measure gene expression with unparalleled single-mRNA resolution. Secondly, we will construct a novel microfluidic setup that for the first time will allow high-throughput timelapse microscopy of developmental processes in live C. elegans animals at the single cell level.Using these techniques in combination with mathematical modeling, we will elucidate the core features of the signaling network essential for robust stochastic cell fate assignment. We will apply this approach to study two stochastic cell fate decisions occurring in gonad development: 1) the so-called AC/VU decision, a classical stochastic cell fate decision that is well-characterized on the molecular level, allowing us to fully focus on how feedback loops reliably amplify noise into all-or-none cell fate decisions. 2) S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Macroscopic Quantum Superpositions' (Q-Xtreme).

assistant: **Innovation**

Do the laws of quantum physics hold for massive objects of arbitrary size? Q-Xtreme will address this very important question by testing the quantum superposition principle at unprecedented macroscopic scales: we will place a levitated object in two locations at once, separated by a distance comparable to its size. Experimental confirmations of macroscopic quantum superpositions started as early as 1927, using electrons, and have today reached the size of organic molecules containing thousands of atoms. Q-Xtreme will bring macroscopic quantum physics to an entirely new level by preparing macroscopic quantum superpositions of objects containing billions of atoms, pushing current state-of-the-art by at least five orders of magnitude in mass. This goal will be achieved by using a radically new approach: quantum controlling the center-of-mass motion of a levitated nanoparticle (a solid-state object of few hundred nanometers) in ultra-high vacuum by using optical, electrical and magnetic forces. Q-Xtreme requires cutting-edge expertise in photonics, nanotechnology, optoelectronics, and quantum technology, which this Synergy Group uniquely combines. The achievements of Q-Xtreme are only possible by the combined proficiency in both fundamental science and engineering of this Synergy Group. The implications of Q-Xtreme are far-reaching. Testing the quantum superposition principle at unprecedented mass regimes opens the door to experimentally study the interplay of quantum physics and gravity, as well as dark matter and dark energy models. These macroscopic quantum superpositions will also give rise to ultrahigh sensing accuracies, with applications in inertial force sensing, measurements of short-range interactions and gravitational physics.


**Keywords:** Levitated nanopartic