RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The economic evaluation of end of life care' to be submitted under Seventh Framework.

assistant: **Abstract**

Making choices about the health care that we provide in society is a fundamental and unavoidable issue. Economic evaluation aids this decision-making by supplying information about costs and benefits of different interventions. For end of life care, however, current evaluative frameworks are inadequate because they focus only on health and only on the patient. Amartya Sen’s capability approach offers an alternative and appropriate framework for evaluating end of life care and this programme aims to build on my ground-breaking work in the application of Sen’s approach to measurement within economic evaluation.  Six key tasks will be undertaken: (i) defining the ‘end of life’ period using semi-structured interviews with key stakeholders; (ii) assessing the construct validity and sensitivity to change of a descriptive system for evaluating capabilities related to end of life care; (iii) eliciting values for this descriptive system from the general public and patients at the end of life using the best-worst scaling technique; (iv) developing a descriptive system to evaluate the impact on families’ capabilities of end of life care, using in-depth interviews to develop conceptual attributes; (v) conducting exploratory theoretical and methodological work on weighting across measures; and (vi) exploring views of the public and key stakeholders about appropriate decision-rules for end of life care, using a combination of focus groups and in-depth interviews. The work involves frontier research at the interface between health, economics and human development.  It will address the significant methodological issues associated with the economic evaluation of end of life care and so advance the state-of-the-art to a point where robust economic evaluation of end of life care is feasib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Research and development of a high performance, broadband generic wastewater seperation technology (MEST)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Scientific objectives and approach:The project starts with the basic idea of separating wastewater streams pressure-less into a fluid and a residue component using a Nickel screen with a specific orifice structure as a filter. The fluid to be processed is transported by means of a jackscrew rotating through this filter. The idea is completely new. First laboratory testing show that the idea is valid, particle sizes down to 50 µm can be separated continuously out of a wastewater stream without using external pressure. By changing the characteristics of the screen itself, without changing the machine set up, a highly flexible separation instrument can be composed suited for a variety of applications. The understanding of filter screen characteristics and separation physics therefore is of utmost importance to meet desired market requirements. Physical and chemical research is carried out concentrating on the filter screen material. Material research is carried out to deal with the variety of process conditions: chemical resistance research (indicators: pH, temperature, fluid composition) as function of material composition with Nickel as main carrier. Physical research is done to understand mechanical behaviour of the screen material.Process settings will be studied for the electroforming processes to compose filter configurations in order to guide the contact angle of the filter orifices and the contacting fluid, temperature effects on passing the filter will be studied, retention will be studied on extreme changing conditions. Parallel to this route a first prototype will be developed having the flexibility of fast turn over of filter screen material. The kinetics of input flows for a variety of product definitions will be studied, the same for the output side, transpor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sub beati Petri et nostra protectione suscipimus: Re-framing the relations between Rome and the kingdoms of Portugal and Aragon (eleventh-thirteenth centuries)' in the context of a Horizon 2020 call.

assistant: **Objectives**

My research project will examine and compare the relations of the Papacy with Portugal and Aragon from the pontificate of Alexander II (1061-1073) to that of Innocent III (1198-1216). Portugal and Aragon have been chosen because were the only political realities in the Iberian Peninsula to enjoy the protection of St Peter in these centuries. These relationships have been interpreted as a feudal bond, but recent studies have started to challenge this image. This analysis will fit into and expand recent discussions of the relations between centre (Rome) and periphery, focusing on an ecclesiological perspective. To whom was the Apostolic See writing? And who was writing to Rome? Why? Did the letters concern practical or theoretical matters? What language and images were adopted by Rome to assert its primacy over Portugal and Aragon and what ecclesiological ideas? Was there ever a feudal bond between these political institutions and Rome? Or was the papacy only reacting to events, claiming a role that it could not play? Was there a particular style in use when writing to the pope? Did ecclesiastics and lay powers adopt similar or distinct formulas when writing to the Apostolic See? These are some of the questions the project aims to answer. Letters issued by the papal chancery are the main source for this kind of analysis because they always entailed the official view of the Roman church on a specific matter, showing the communication strategies and the ecclesiological ideas adopted by the Apostolic See to assert Roman primacy. Missives sent to the popes also played a decisive role in the creation of papal images. This project will shed light not only on the papacy and on the strategies adopted to support its claims of primacy, but also on views of the Roman church from a f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Design, Synthesis, Characterization and Catalytic Application of Silyliumylidene Ions' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This ERC-StG 2014 proposal, SILION, outlines a strategy for the one-pot synthesis, characterization, and reactivity investigation of a positively charged, electron-deficient, highly Lewis acidic, cationic silicon(II) species, denoted “silyliumylidene ions”. Silyliumylidene ion has only four valence electrons, consisting of a lone pair of electrons and two vacant orbitals on the central silicon atom. It will be expected to bear the best combined character of both silylenes as silicon analogue of carbene and silylium ions as silicon analogue of carbenium ions. The program described herein is also aimed at the development of silyliumylidene ion as novel catalysts based on main group elements. The proposed silyliumylidene ions should fulfil the following criteria: a) compounds can be synthesized by a facile one-pot reaction of the corresponding dichlorosilane with two equivalents of N-heterocyclic carbenes, b) silyliumylidene ions will potentially possess three reactive sites including (i) a lone pair at the silicon center, (ii) p-orbital at the silicon center, and (iii) N-heterocyclic carbenes, c) thanks to their strong sigma-donor as well as pi-acceptor ability, the highly reactive silyliumylidene ions are expected to serve as innovative reagents for activation of organic small molecules, excellent catalysts, and strikingly versatile coordination ligands toward transition metals.  The target of this proposal is the introduction of facile accessible silyliumylidene ions, which are combined the best properties of silylene and silylium ions, and development of its reactivity and catalytic activity. The synthesis of silyliumylidene ions is straightforward and should allow the investigation of electronic and steric properties of the substituents and N-heterocyclic carbenes. It
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Helicopter View on Electrocatalysis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Converting carbon dioxide, an unwanted by-product of industrial processes and combustion engines, into valuable chemical compounds is key for a cyclic carbon economy and can be achieved by the electrochemical CO2 reduction reaction (CO2RR). Despite the immense importance of this reaction in the fight against climate change, no catalyst to date meets the industrial requirements for product selectivity and catalyst stability. Theoretical models and simulations have played a fundamental role in the understanding of these and similar catalytic processes and aided the development of more efficient catalysts for this reaction. These models, however, assume few often idealized surface structures, ignoring the fact that a variety of structures is present under working conditions that define the catalyst properties in terms of efficiency, selectivity, and stability. With HeliECat, I will for the first time establish an approach that offers a holistic view of the catalytic processes, including side reactions and degradation mechanisms. To achieve this ambitious goal, I will combine an efficient semiempirical model for structural exploration with accurate embedded cluster models for kinetic studies. This combination shifts the focus from idealized structures to the diversity of the catalyst surface under realistic conditions. I will then model the interconversion of accessible surface structures with deep reinforcement learning techniques. The analysis of the emerging connected kinetic reaction networks will ultimately allow me to simultaneously study the catalytic activity, stability, and selectivity in silico. I will study the CO2RR on a Cu/Au catalyst surface and demonstrate that automated kinetic modeling, considering structural diversity and realistic thermodynamic boundary c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Evolutionary Medical Genomics Doctoral Network' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The Evolutionary Medical Genomics Doctoral Network (EvoMG-DN) pioneers an integrative approach combining Evolutionary Medicine and Medical Genomics to address critical health challenges. By combining evolutionary insights with state-of-the-art genomic tools, EvoMG-DN seeks to establish EvoMG as a structured and impactful discipline in Europe. The network aims to train the next generation of interdisciplinary researchers to unlock the full potential of evolutionary genomic approaches in healthcare.EvoMG-DN pursues three overarching objectives: (i) foster interdisciplinary synergy by uniting EvoMG researchers from diverse fields to catalyze innovation in methodologies and tools; (ii) create a cohesive training framework, equipping doctoral candidates (DCs) with expertise in EvoMG applications through structured training and collaboration; and (iii) advance evolution-informed clinical applications, such as adaptive cancer therapies.The research program is organized into three scientific work packages: WP1 explores evolutionary insights into ageing and age-related diseases; WP2 focuses on tumor evolution and acquisition of resistance in cancer therapies; and WP3 addresses pathogen evolution, antibiotic resistance and interactions with the immune system. These are underpinned by core methodological pillars, which include comparative functional genomics, genetic diversity analysis, mathematical modeling and machine learning, and the use of unconventional model organisms.Through interdisciplinary secondments, tailored mentoring, and advanced training modules, EvoMG-DN empowers DCs to bridge disciplines and develop actionable solutions to global health challenges. By formalizing EvoMG methodologies and advancing clinical applications, EvoMG-DN aims to solidify Europe’s leadersh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploring the human brain using magnetic resonance imaging and parallel transmission at ultra-high field' (EXPAT), addressing dissemination and exploitation.

assistant: **Impact**

Full exploitation of ultra high field magnetic resonance imaging (MRI) requires innovative methods to control the homogeneity and the safety of the high frequency radiofrequency (RF) waves used to acquire images. This can be achieved by using parallel transmission of the RF waves to boost the number of degrees of freedom, but its complexity has thus far deterred its wide use. The aim of EXPAT is to apply sophisticated quantum information processing (QIP) techniques to manipulate the nuclear spins efficiently with parallel transmission at ultra high field MRI on the state-of-the art 7 Tesla and the unique 11.7 Tesla MRI scanner that will be installed at NeuroSpin/CEA. By bringing a practical solution to parallel transmission at such high field strength, EXPAT will be a major breakthrough for MRI of the brain.Radiofrequency pulse design departing from traditional MRI concepts thus will be a central aspect of this project. Mathematical concepts will be applied to describe efficiently sub-classes of RF waveforms leading to non-trivial and useful dynamics, thereby providing a minimum number of parameters to be used as ingenious “control knobs” to design parallel transmission pulses and explore regimes of spin excitation hardly accessible by current formalisms. Another novel aspect will be to revisit entirely the way RF safety is handled by taking directly into account the temperature in the human head during scanning and at pulse design stage, rather than the indirect specific absorption rate currently used in MRI. Tracking temperature will relax the constraints in RF pulse design as well as in data acquisition strategies by at least a factor of two, while strictly enforcing safety. Subject-based radiofrequency field characterization, model validations, MRI sequence developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of biotherapies for growth plate disorders', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Skeletal dysplasias are a diverse and heterogeneous group of hereditary disorders characterized by malformations of bone and cartilage. These conditions affect development patterns in bones of growing children, and the clinical severity ranges from mild short stature to highly disfiguring, and even to lethal forms. Their treatment is very challenging, typically with no or limited success. This proposal is designed to explore the use of gene- and stem cell-based approaches to influence bone development in growth plate disorders characterized by aberrant constitutive cellular signaling in the growth plate chondrocytes. These biotherapeutic technologies offer the unique opportunity to manipulate and influence the cells in the developing growth plate, and if successfully applied, may functionally rescue bone growth and restore normal skeletal development. In this study, we will work to gain fundamental knowledge necessary for the rational design of a therapy for achondroplasia and Noonan syndrome. In attempting to address skeletal dysplasias, we have chosen to focus on these diseases because they are caused by gain-of-function point mutations affecting intracellular signaling in growth plate chondrocytes, and there exists transgenic mouse models containing mutations identical to that found in affected patients. The following specific aims will be addressed: Aim 1- To determine the biological effects of systemic gene delivery and overexpression of sFGFR3 in Fgfr3ach/+ mice. Aim 2- To determine if overexpression of sFGFR3 or inhibition of SHP2 expression can restore growth in bones from Ptpn11D61G/+ mice in an organ culture system. Aim 3- To determine the capacity of exogenous stem cells to influence the biology of diseased growth plate in vivo. The fellowship will contribute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Factors regulating the composition of aquatic bacterial communities at the local scale' (METACOMBA) under Seventh Framework.

assistant: **Objectives**

One key question in ecological research is which factors regulate community composition and diversity at various temporal and spatial scales. Since bacteria are key drivers of ecosystem function, it is of particular importance to focus on mechanisms regulating their community structure to be able to make predictions about the effects of environmental changes on biogeochemical cycling. In the proposed project I will implement a number of field surveys as well as laboratory and field experiments using bacterial communities in rock pools as model systems. The project investigates the importance of local and regional factors for bacterial community composition and assembly, the character and extent of ecological differentiation within bacterial communities, and the effect of disturbance intensity and frequency on bacterial community composition. This project will therefore significantly advance our knowledge about bacterial biogeography, regulating factors of microbial diversity, and microbial metacommunity ecology. It will also help us to understand to which degree bacterial community composition is predictable from the environmental conditions and provide insights into the resistance and resilience of bacterial communities after a disturbance event. This information will help us to validate whether predictable changes in microbial communities and associated ecosystem processes may occur as a result of climate or environmental change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'On-Chip Cytometry Printed On Demand'.

assistant: **Concept**

Cytometry (the characterisation and counting of cells) is essential to clinical diagnostics, biotechnology, food industry, water monitoring and many fields of research. Within the ERC Starting Grant, InstantCount, inkjet printing methods have been developed, which allow us to fabricate cell counting chambers with on-chip sample preparation, simplifying cell counting procedures tremendously. By effectively eliminating all sample preparation steps and efficient usage of reagents CyPod promises low-cost, simple, rapid cell counting, including mobile applications. The fabrication by inkjet printing enables us to offer tailor-made solutions. We expect that CyPod tests can replace expensive and complex instruments in many existing cell counting applications, as well as open new markets, e.g. in agriculture and food industry. This project aims at evaluating and enhancing the competitiveness of CyPod cell counting technology by analysing the market, comparing CyPod with potential competitors and adapting our concept to identified customers’ needs. A product demonstration for potential customers and partners will be prepared and the optimal business strategy will be selected for which a business plan will be devised.