RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Novel, Comprehensible, Ultra-Fast, Security-Aware CPS Simulator' (COSSIM).

assistant: **Innovation**

One of the main problems the CPS designers face is “the lack of simulation tools and models for system design and analysis”. This is mainly because the majority of the existing simulation tools for complex CPS handle efficiently only parts of a system while they mainly focus on the performance. Moreover, they require extreme amounts of processing resources and computation time to accurately simulate the CPS nodes’ processing. Faster approaches are available, however as they function at high levels of abstraction, they cannot provide the accuracy required to model the exact behavior of the system under design so as to guarantee that it meets the requirements in terms of performance and/or energy consumption. The COSSIM project will address all those needs by providing an open-source framework which will a) seamlessly simulate, in an integrated way, both the  networking and the processing parts of the CPS, b) perform the simulations orders of magnitude faster, c) provide much more accurate results especially in terms of power consumption than existing solutions,d) report more CPS aspects than any existing tool including the underlying security of the CPS. COSSIM will achieve the above by developing a novel simulator framework based on a processing simulation sub-system (i.e. a “full-system simulator”) which will be integrated with a novel network simulator. Furthermore, innovative power consumption and security measurement models will be developed and incorporated to the end framework. On top of that, COSSIM will also address another critical aspect of an accurate CPS simulation environment: the performance as measured in required simulation time. COSSIM will create a framework that is orders of magnitude faster, while also being more accurate and reporting more CPS aspec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'hSpindly, a new regulatory protein of the SAC mechanism and its implication in tumour therapy' to be submitted under Horizon 2020.

assistant: **Abstract**

During mitosis a sophisticated surveillance system, known as the spindle assembly checkpoint (SAC), is crucial to make sure that the cell does not separate its sister chromatids until all the chromosomes are correctly attached to spindle microtubules and bi-oriented.Nowadays, one of the more important strategy used for the cancer treatment is the inhibition of the microtubule dynamic to activate the SAC by the addition of anti-mitotic drugs. At the end, the activation of SAC for a long period provokes the cell death, compromising the tumour cell proliferation. Nonetheless, there are tumour cells, which are affected in SAC activity showing a reduction in the efficiency of this treatment. For this reason, it is becoming extremely useful to seek new proteins which are implicated directly to SAC functionality.This project will be focused on the study of hSpindly as a new protein implicated in SAC regulation independently of the stripping pathway. hSpindly has a role in the SAC mechanism but how it works is absolutely unknown. hSpindly is highly phosphorylated in mitosis so, finding the residues which are phosphorylated in this cell cycle phase, will allow us to know not only the role of these phosphorylations in SAC but also its implication in the cell response in the presence of antimitotic drugs. For this, we will use several approaches and state of the art techniques as confocal microscopy and the CRISPR/Cas9 nickase system. This study will contribute with relevant results in basic and clinical research. The knowledge of the hSpindly function might reveal new therapeutic targets for the treatment of the tumours more resistant to anti-mitotic drugs. Additionally, it would be possible to get phosphospecific antibodies of key residues in the hSpindly function, which could b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Characterisation of the e1a associated p300/cbp protein family and their role in gene expression, cell cycle control and differentiation' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content E1A protein is involved in regulation of gene expression, apoptosis and cell differentiation. It interacts with p300/CBP, pRB and related pocket proteins. It is believed that E1A acts by sequestering its targets, therefore inhibiting their interaction with other proteins. Since p400 and p270 are potentially new members of the p300/CBP protein family, I aim to understand their role in cell cycle differentiation and transcriptional regulation. p400 and p270 will be isolated by immunopurification. It is known that p300/CBP is capable of acetylating histones and contribute in transcription regulation. In order to study this part of the gene activation, I will study the interaction between p400 and p270 with p300 associated histone acetylation factors, such as P/CAF. Most proteins that interact with P/CAF keep the cell cycle in check, presumably by turning on genes that inhibit cell growth while turning off those that might foster cell division. E1A binding to p300/CBP displaces P/CAF from the complex, and this may alter the acetylation activity, allowing expression of genes that enable cells to start dividing and preventing the expression of genes that inhibit cell division. The effects of p400 and p270 on cell cycle progression and transcriptional regulation will be analysed by using FACS analysis and E2F mediated enhancement. Training content (objective, benefit and expected impact) The research described, aims to further our understanding of the p300/CBP protein family. This study will be of fundamental importance in understanding the cell cycle progression and differentiation in both normal and malignant cells. In addition, this study can link the basic research with industrial applications, since it may lead to the design of molecules fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High resolution holocene co2 reconstruction from fossil plants', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content THIS RESEARCH PROJECT AIMS AT A BETTER UNDERSTANDING OF THE PAST VARIABILITY IN ATMOSPHERIC CO2 CONCENTRATION, SPECIFICALLY IN THE HOLOCENE PERIOD (THE LAST 10,000 YEARS). THIS IS VERY IMPORTANT FOR OUR POSSIBILlTIES TO ASSESS THE RISKS ASSOCIATED WITH THE LARGE INCREASE IN CARBON DIOXIDE CONCENTRATION DURING THE LAST 200 YEARS AND FOR OUR UNDERSTANDING OF THE CLIMATE SYSTEM IN GENERAL. RECONSTRUCTIONS OF HOLOCENE CO2 VARIATIONS WITH THE REQUIRED RESOLUTION HAS SO FAR NOT BEEN POSSIBLE FROM THE ANTARCTIC AND GREENLANDIC ICE CORES DUE TO INHERENT PROBLEMS IN THAT TECHNIQUE. THERE ARE ALSO INDICATIONS OF LARGE DISCREPANCIES IN THE ICE-CORE DATA. THIS CALLS FOR INDEPENDENT EVIDENCE. THE DENSITY OF STOMATAL CELLS IN LEAVES HAS BEEN SHOWN TO BE INVERSELY RELATED TO ATMOSPHERIC CO2 CONCENTRATION, AND BY APPLYING THIS TO FOSSIL LEAVES IT IS POSSIBLE TO RECONSTRUCT PAST CO2 VARIATIONS. THE OBJECT OF THIS PROJECT IS TO APPLY THIS RELATIVELY NEW METHOD TO HOLOCENE LEAVES OF TWO TUNDRA SPECIES TRAPPED IN SWEDISH LAKES, THEREBY PRODUCING TWO INDEPENDENT HIGH RESOLUTION CO2 RECONSTRUCTIONS FOR THE LAST 10,000 YEARS. THE COLLECTED SEDIMENTS WILL BE SEARCHED FOR FOSSIL LEAVES AND THESE WILL BE IDENTIFIED STOMATA AND EPIDERMIS CELLS WILL BE COUNTED UNDER AN EPIFLUORESCENCE MICROSCOPE AND STOMATAL INDEX CALCULATED. SOME LEAVES WILL ALSO BE USED FOR AMS RADIOCARBON DATING TO SECURE RELIABLE CHRONOLOGIES. Training content (objective, benefit and expected impact) I WILL RECIEVE TRAINING IN THE USE OF FOSSIL LEAVES FOR RECONSTRUCTION OF PAST CO2 ATMOSPHERIC CONCENTRATION, INCLUDING STOMATAL INDEX MEASUREMENTS ON LEAVES. THIS IS A RELATIVELY NEW APPROACH IN PALAEOCLIMATOLOGY THAT HAS SHOWED VERY PROMISING RESULTS. THIS TRAINING WILL MAKE IT POSSIBLE FOR ME TO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A revolutionary gait analysis system for smart injury and performance management.' to be submitted under Horizon 2020.

assistant: **Abstract**

The cost of player injuries is astonishingly high. The estimated average cost of player injuries in the top 4 professional soccer leagues in 2015 was $12.4 million per team. It is estimated that every year soccer teams lose an equivalent of 10%-30% of player payroll to injuries. This means that even a small reduction in the number of injuries could add up to big savings. So imagine if half of all professional sports injuries could be prevented? The savings for men’s football leagues alone would be well over a billion dollars a year.Given this incentive, sports institutes are investing heavily in ways to reduce injury occurrence and improve rehabilitation speeds. Gait analysis, the systematic study of a person’s movement, is one of the most efficient biometric solutions to these problems. Despite this, traditional methods of gait analysis rely on static, expensive equipment restricted to lab-based environments only. The data analytics from these platforms is also overcomplicated and requires work and training to understand. Due to this, there is a lack of personnel who can accurately and meaningfully interpret the data.Kinetika Limited, trading as Danu Analytics, is an innovative Irish start-up company providing a novel gait analysis system for injury and performance management in the sports industry. We are working with elite sports professionals and medical experts to develop a novel wearable system that removes the restrictions of traditional lab-based gait analysis.Our product provides coaches, physiotherapists and athletes with unrestricted, scientifically validated, gait analysis in any environment, at any time. This empowers them with the tools to reduce injury occurrence, reduce rehabilitation times and maximise athletic ability.In this feasibility study, the com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainable Marine Energy and Ecosystem Resilience Advancement through Digital Technologies and Real-Time Crisis Management' to be submitted under Horizon Europe.

assistant: **Abstract**

The project aims to strengthen EU efforts towards achieving climate neutrality and achieving green energy and environmental targets. SeaDream plays a crucial role in making sure marine energy is utilized sustainably and coastal environments are preserved in line with EU policies.The development of a high-resolution water quality data service at sea is at the core of SeaDream's mission. Data such as these are crucial to addressing specific questions regarding maritime renewable energy generation and storage. The project integrates local monitoring data and advanced modeling through the development, testing, and demonstration of novel downstream information services in an operational mode. As a result of this integration, marine activities related to the generation and storage of energy are improved, and environmental objectives are not compromised. By harnessing advanced data and fostering collaboration across sectors, the project aims to contribute significantly to the EU's environmental and energy targets, promoting a path towards climate neutrality.In order to achieve SeaDream's vision, a coordinated research program that thrives on collaboration is implemented. In this program, leading teams from academic and private sectors are seconded within and outside the EU. Collaborations are enhanced by periodic workshops and summer schools that disseminate the latest findings and promote market-relevant knowledge application.It is designed to foster the advancement of knowledge and career development for both experienced and early career researchers and professionals. To ensure this, secondments and training activities are structured to ensure a comprehensive approach to learning and development. Additionally, the SeaDream consortium includes nonacademic partners from variou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sea Urchins in integrated systems; their nutrition and roe enhancement' in the context of a Sixth Framework call.

assistant: **Objectives**

The biological basis for culture of sea urchins has been established but the developing industry is now meeting particular constraints. These are: The lack of DIETS, which improve roe colour, while maintaining the other quantity and consistency parameters demanded by the market (flavour, texture, quantity). The lack of GROW-OUT TECHNOLOGY to reduce time to market. The lack of HARVEST PROTOCOLS positively influencing shelf-life and product quality.This proposal addresses these constraints by:- Uniting the leading SME's in sea urchin culture in Europe with experienced researchers who are best able to assist them.- Focusing on the two most commonly fished, farmed and consumed sea urchin species in Europe.- Investigating roe colour, which is a critical factor in the commercial product; poor or variable gonad colour at point of sale has a detrimental effect on the value in all species. The project will investigate the pigment (carotenoid) content of sea urchin roes to facilitate the design of sea urchin diets containing pigments from natural sources (eg microalgae). The diets will be species specific and improve roe content and colour.- Innovations in grow-out technology; the culture systems proposed in this research are all integrated, linking se a urchin culture to that of other species with environmental and economic advantage.- Developing protocols for microbial food safety will further enhance the competitiveness and market compliance of the product.While helping fulfil the aims of the 'Strategy for the Sustainable Development of European Aquaculture' this research will also help relieve the pressure on the remaining, vulnerable wild urchin populations. The research will have a positive impact on other sectors; e.g. seafood retailers, anima l-food manufacturers, food pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Characterisation Of Rhizaria in modern Oceans: from living cells to fossils'.

assistant: **Innovation**

Can we simultaneously learn from past, present, and future oceans by studying plankton? For 521 million years, Rhizaria have abundantly and ubiquitously populated all oceans from the surface to the deep. They have biomineralised intricate skeletons by using silicon, thus impacting marine biogeochemical cycles. Upon death, their skeletons can become fossils and reflect ancient planktonic life. Yet, do fossils reflect all Rhizaria populations living in the water column? What is the fate of some large biomasses of contemporary Rhizaria that would have not been preserved as fossils? Ultimately, what is the interplay between live and fossilised forms? ChORhizO will provide a holistic and cross-disciplinary view of these questions, bridging disciplines from oceanography, biogeochemistry to micropaleontology. Rhizaria stocks, gravitational fluxes and fossil records will be quantified using a variety of innovative methods, from experimental to in situ approaches, from living cells to fossils. Oceanographic expeditions will be conducted in two contrasted oceanic basins (the Southern Ocean and Mediterranean Sea), where we observe imbalances between Rhizaria biomass and fossil composition. These basins will provide us with an opportunity to consider diverse water column alteration processes (i.e., taphonomy) that govern fossil record formation. New Vision moorings will be developed to investigate the detailed interplay between stocks and fluxes, ultimately fuelling fossil records. Over a period of two years, they will simultaneously quantify in situ both aspects at unprecedented scales: specimens spanning five orders of magnitude in size will be quantified along the entire water column. A precise understanding of how and which populations are reflected in fossil records will allow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'VALORISATION OF HARVESTED AGROFORESTRY BIOMASS WASTE AS FEEDSTOCK FOR VALUE-ADDED BIO-BASED SOLUTIONS AS A GREEN DEVELOPMENT PATHWAY' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

HarWASTing aims to develop innovative business models based on circular economy (CE) principles to promote bioeconomy in rural areas, by implementing a set of scalable and replicable technological solutions to efficiently exploit underutilised biomass from forestry and agriculture to develop innovative and high-value products. These models will support sustainable management practices and will promote an efficient use of natural resources, reducing overall waste generation and post-harvest losses by implementing valorisation processes and fostering CE principles. To this end, a methodology will be implemented to collect, treat and revalorize biomass from forest and agricultural harvest, pruning waste and bioethanol process side-streams, respecting the cascade principle for biomass use. A one-fits-all technology, Hydrothermal Carbonization, for a higher energy efficient treatment of lignocellulosic biomass residues will be combined with Pressurized Hot Water Extraction and innovative post-treatment technologies, to develop high-value added products and avoid any non-valorised side-stream. The whole concept will be demonstrated at small-scale pilot, built-upon existing wood, food and bioenergy value chains to further strengthen their economic and environmental sustainability through synergistic interlinkages between them. Mediterranean, Boreal and Continental bioregions will be studied.The holistic concept is based on the central valorisation route of Hydrothermal Carbonizationand its solid product, hydrochar, that is converted into hybrid wood-hydrochar panels with less than 10% of bio-adhesive for special applications such as fire protection or electromagnetic shielding. A novel support AI-based digital tool for forecasting agroforest feedstock availability will be deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Freshly baked breads with improvement of nutritional quality and low energy demanding for the benefit of the consumer and of the environment.' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This project concerns the BAKE OFF TECHNOLGY (BOT), which consists in producing bakery goods from industrial refrigerated or frozen bakery goods and to retail them in downtown baking shops OR to make them available in supermarket for domestic baking. Bread consumption, which is at the base of the human diet is growing very slowly (~ 1%/year), whereas BOT is growing by ca 10%/year. Indeed, the consumer wants freshly baked bread at any time of the day. So far, BOT has mainly concentrated its efforts on mass production of plain breads made with white flour and low nutritional value. Partially baked bread is leading the market (>50%), whereas this product, which is baked two times is energy demanding and addresses quality problems (rapid staling, crust flaking). Gluten free breads are almost absent of the BOT because removing gluten from the formulation of bread is a real challenge. Beside, Celiac disease (gut disorder related to gluten allergy) affects ca. 0.1% people in Europe. This project addresses important strategic objectives:-To develop bread formulations (incl. gluten free breads) with enhanced nutritional value, following the European Regulation on Nutrition and Health, adapted to the BOT -To reduce energy consumption of BOT -To develop innovative ingredients with low chemicals that will support these new pathways-To organize and perform workshops to present and demonstrate the results of the project, where both project participants and other bakeries (giving priority to SME bakeries) will be invited. -To develop tools that will permit to extend the findings of the project to future formulations and developments. These objectives will be achievable by evaluating the expectation of European consumer against breads with health benefit, by developing specific tools t