RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EXPLORING SUSTAINABLE STRATEGIES TO COUNTERACT TERRITORIAL INEQUALITIES FROM AN INTERSECTIONAL APPROACH' (EXIT).

assistant: **Concept**

The redrawing of social inequalities across Europe during the last few years includes both a retrenchment of longstanding inequalities among countries, and the emergence of new disadvantages, together with an erosion of the status and protections previously enjoyed by most citizens within them. This is particularly prominent from a geographical perspective as spatial inequality grows within regions. Despite overall country level economic growth, certain regions are experiencing long-term socioeconomic stagnation or decline. These areas have been often characterised as 'left-behind'. Yet, little is known of what drives ‘left-behindness’. EXIT will provide an in-depth analysis of ‘left-behind’ as a concept used for characterising territorial inequalities faced by certain areas and, grounded on this, identify strategies to address it. This means not only building knowledge on the drivers of inequality in areas that are characterised as ‘left-behind’, but also on what drives political, media and academic characterisations of these areas as ‘left-behind’ and experiences and perceptions of being ‘left-behind’ among inhabitants of areas experiencing socioeconomic stagnation or decline. To answer these questions, EXIT proposes a bottom-up, interdisciplinary and mixed-methods research with a community-based and intersectional approach from the analysis to the transferability of practices. Addressing how different axes of inequality intersect in perceptions and experiences of ‘left-behindness’ is crucial to understand the gap between the development of policies to redress territorial inequalities and their impact on the ground. In this regard, EXIT proposes to take a place-based approach to delineate the role of different forces, and how they interplay to produce uneven effects a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FOUNDATIONS FOR CONTINUOUS ENGINEERING OF TRUSTWORTHY AUTONOMY' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Ubiquitous AI will soon allow complex systems to drive on our roads, fly over our heads, move alongside us during our daily lives & work in our factories. In spite of this disruptive landscape, deployment and broader adoption of learned-enabled autonomous systems in safety-critical scenarios remains challenging. Continuous engineering (DevOps) can mediate problems when encountering new scenarios throughout the product life cycle. However, the technical foundations and assumptions on which traditional safety engineering principles rely do not extend to learning-enabled autonomous systems engineered under continuous development.FOCETA gathers prominent academic groups & leading industrial partners to develop foundations for continuous engineering of trustworthy learning-enabled autonomous systems. The targeted scientific breakthrough lies within the convergence of “data-driven” and “model-based” engineering, where this convergence is further complicated by the need to apply verification and validation incrementally & avoid complete re-verification & re-validation efforts.FOCETA’s paradigm is built on three scientific pillars: (1) integration of learning-enabled components & model-based components via a contract-based methodology which allows incremental modification of systems including threat models for cyber-security, (2) adaptation of verification techniques applied during model-driven design to learning components in order to enable unbiased decision making, & finally, (3) incremental synthesis techniques unifying both the enforcement of safety & security-critical properties as well as the optimization of performance.FOCETA approach, implemented in open source tools & with open data exchange standards, will be applied to the most demanding & challenging applications s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Revealing liver micrometastases in vivo using ultra-high definition MRI' in the context of a Horizon Europe call.

assistant: **Objectives**

Over 90% of cancer-related deaths are caused by metastases. A major obstacle for accurate patient stratification, development of new treatments against metastases and thorough biological understanding is our inability to detect early-stage micrometastases (µMets). The liver is one of the first and most common sites for metastases, particularly in gastrointestinal tract tumours. Thus, early detection of liver metastases is an urgent need in cancer diagnosis for many patients. Present image-based diagnostic methods, including state-of-the-art Magnetic Resonance Imaging (MRI), cannot detect µMets due to major limitations in current image contrast and resolution, as well as a lack of understanding of liver tissue changes during the metastatic process.MicroMetSCAN proposes a paradigm-shifting MRI approach based on highly promising preliminary results that leverages recent progress in MRI acquisition, denoising and contrast generation, to reach the breakthrough of exquisite sensitivity and specificity required to detect and characterise μMets in the liver and provide new insights about metastases-related tissue microenvironment dynamics. To achieve its overarching goal, my proposal consists of four objectives: 1) developing new ultra-high resolution MRI methods targeting robust µMets detection, 2) tailoring the specificity of contrasts towards μMet environments, 3) unravelling the transformations from µMets to full metastases in animal models, yielding critical insights into tumour growth patterns, and 4) translating the new MRI approach to the clinic in a prospective clinical study. MicroMetSCAN will significantly advance the state-of-the-art in cancer imaging, to enable precision diagnosis and treatment planning, with wide-reaching applicability, especially benefitting smal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Critical Heritage Studies and the Future of Europe_Towards an integrated, interdisciplinary and transnational training model in cultural heritage research and management' (CHEurope).

assistant: **Concept**

CHEurope focuses on developing a new integrated theoretical and methodological framework to enhance the academic and professional training and open future job opportunities in cultural heritage preservation, management and promotion. Heritage has commonly been perceived through its contingent relationship to other areas, preventing it to be considered as a ‘legitimate’ scientific discipline. Moreover, research and practice in this field are still too often seen as separate dimensions. Thus, there is an increasing need to address these diverging trends in the expanding heritage industry with a critical approach that situates cultural heritage in its social, economic and political frameworks, as well as in professional practice. Bringing together a network of key European academic and non-academic organisations, the project will explore the processes by which heritage is ‘assembled’ through practice-based research in partner institutions that connect students to their future job markets and publics. Our aim is to inform more conventional aspects of cultural heritage designation, care and management with a strong focus on present and future consumers. We propose an advanced learning strategy based on the emerging field of Critical Heritage Studies, which combines theoretical and instrumental knowledge at a transnational and interdisciplinary level, in a series of research seminars, summer schools and secondments. The program is based on themes where cultural heritage is undergoing profound change, such as Heritage Futures, Curating the City, Digital Heritage, Heritage and Wellbeing and Management and Citizen Participation. In so doing, this research will have a direct impact on future heritage policies and be linked explicitly to new modes of training. These will enable fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'BESPOKE – Bacterial Enzyme and Surface Polymer Exploration Kit' under Horizon Europe.

assistant: **Concept**

Antimicrobial resistance (AMR) is a major health challenge and predicted to be associated with 8-10 million deaths per year by 2050. Gram-positive pathogens from the genus Enteroccocus and Gram-negative extra-intestinal pathogenic Escherichia coli (ExPEC) are critical multidrug-resistant bacteria for which effective therapies are urgently needed. Both pathogens cause various types of infections, can survive in different biological niches, and can even be a beneficial part of the human gut microbiome. Glycoconjugate vaccines have proven highly effective for the prevention of bacterial infections. However, their development for Enterococcus spp. and ExPEC infections is hindered by the lack of knowledge about (i) the diversity, structure and identity of cell surface polymers expressed on Enterococcus spp. and ExPEC, (ii) how these polymers determine the biological niche a strain inhibits or the type of infection it causes, and (iii) what polymers to target to distinguish between beneficial and harmful strains.In BESPOKE we will explore and exploit bacterial cell surface polymers of Enterococcus spp. and ExPEC in an unprecedented manner. Using a bottom-up approach - from genome, to enzyme, to polymer – we aim to synthesize and structurally characterize the cell surface polymers in a pathogen-free way to elucidate the structural diversity that is presented to the human immune system during various types of infection. In addition, we will explore and biochemically investigate the as yet poorly understood cell wall polymer biosynthesis machineries on genome and enzyme level to make them available as marker for the surveillance of local epidemiology and as synthesis tools for biotechnological exploitation. Finally, we aim to build a highly versatile mix-and-match platform for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Linking biological databases using the common object request broker architecture' to be submitted under Fourth Framework.

assistant: **Abstract**

Databases in the biosciences describe a wide spectrum of complex biological information distributed throughout Europe, and the world. The diversity of these databases makes efforts towards integrating and accessing these data difficult. The Common Object Request Broker Architecture is an international standard developed by the world's largest software consortium. It specifies a coherent framework in which distributed applications can interoperate. Such a standard is crucial in the linking of biological databases. This project will provide a critical appraisal of this standard and an empirical validation through implementation experience. The project will cover a diverse set of data. These data include several of the larger established databases (EMBL, SwissProt, PIR, MSD, GDB) and several new and emerging databases (TRANSFAC, P53, RHdb). Services and client applications will be developed that exploit these data. These applications will contain new client programs that allow access to integrated views of these underlying data. This project is a vital step towards providing the infrastructure required to realise the wealth of information held in the ever increasing number of databases with which the biologist must contend.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Use of CpG oligodeoxynucleotides to improve the immunogenicity of vaccines' (2002-2006).

assistant: **Concept**

The specific aim is to develop novel strategies to improve the immunogenicity of vaccines targeting bioterror pathogens, focusing on AVA (anthrax vaccine adsorbed) and recombinant protective antigen (rPA) as the potential candidates.The intent is to examine the use of a toll like receptor 9 (TLR9) ligand (a synthetic oligodeoxynucleotide expressing CpG motifs (CpG ODN)) in three settings:i) As a stand-alone agents to improve the host's capacity to resist infection by anthrax, ii) As a vaccine adjuvant, accelerating and magnifying the anti-PA antibody response elicited by a co-administered AVA and recombinant protective antigen (rPA) vaccines, andiii) As an adjuvant in combination with AVA or rPA delivered by novel means (by sterically stabilized cationic liposomes) to boost anti-PA or immunoprotective immunity.Finally, by incorporating other TLR ligands (such as dsRNA, MALP-2, PAMCys3, and loxoribine, ligands for TLR3, TLR2/6, TLR2, and TLR7/8 respectively) in the final formulation we plan to augment the adjuvant effect mediated by CpG ODN, thereby improving protective performance of the vaccine.  Studies planned for this proposal will examine whether the addition of CpG ODN to the AVA (or rPA antigen) vaccine 1) elicits a more rapid protective immune response than AVA alone and 2) will have an antigen sparing effect, allowing the use of less AVA and thus decreasing the reactogenicity associated with AVA vaccination.We also plan to investigate the use of CpG ODN and AVA complexed to be co-encapsulated in liposomes (which improve the targeting and subsequent simultaneous presentation of the vaccine and adjuvant to antigen presenting cells, thus improving uptake and immunogenicity). Results from these studies should have considerable applicability to other vaccines target
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Near Infrared Perovskite Light Emitting Diodes Integrated into a Silicon Nitride Photonic Platform: Technologies Hybridization' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

IPER-TECH will demonstrate the integration of an array of efficient tin-based perovskites LEDs, with steerable emission in the NIR-I spectral range, into a photonic integrated platform based on silicon nitride. The latter is recognized as a key technology due to its compatibility with the complementary metal–oxide–semiconductor (CMOS) manufacturing infrastructure and the potential for integration with back-end-of-line Si microelectronics. Integrated optical platforms are an essential development for the implementation of complex functionalities that are becoming increasingly sophisticated in their applications.IPER-TECH will demonstrate the integration of an array of efficient tin-based perovskites LEDs, with steerable emission in the NIR-I spectral range, into a photonic integrated platform based on silicon nitride, which is recognized as a key technology due to its compatibility with the complementary metal–oxide–semiconductor (CMOS) manufacturing infrastructure and the potential for integration with back-end-of-line Si microelectronics. Integrated optical platforms are an essential development for the implementation of complex functionalities that are becoming increasingly sophisticated in their applications. In this context, a big technological gap is present in the NIR spectral range, which cover nearly all aspects of our daily life. In fact, commercial NIR light emitting diodes (LEDs), which commonly employ epitaxial heterostructures of III–V inorganic semiconductors as emitting materials (e.g., GaAs, InGaAs, etc.), cannot be integrated.The demonstration of a new hybrid technology for photonic applications will enable otherwise unachievable functionalities for diversified applications ranging from night vision to optical communications, data storage and biomedical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High efficiency, high power density, cost effective, scalable and modular power electronics and control solutions for electric vehicles' in the context of a Horizon Europe call.

assistant: **Objectives**

Focused on BEV architectures with distributed multiple wheel drives, and, specifically, in-wheel powertrains, HighScape will explore the feasibility of a family of highly efficient power electronics components and systems, and including integrated traction inverters, on-board chargers, DC/DC converters, and electric drives for auxiliaries and actuators. The proposed solutions will be assessed on test rigs and on two differently sized BEV prototypes. The project will result in: i) component integration with the incorporation of the WBG traction inverters within the in-wheel machines to achieve zero footprint of the electric powertrain on the sprung mass; the functional integration of the traction inverter with the on-board charger, and the incorporation of the latter and the DC/DC converters within the battery pack; and the implementation of multi-motor and fault-tolerant inverter solutions for the auxiliaries and chassis actuators; ii) novel solutions, including the implementation of reconfigurable winding topologies of the drive, as well as integrated and predictive thermal management at the vehicle level, with the adoption of phase changing materials within the power electronics components; iii) the achievement and demonstration of significantly higher levels of power density, specific power and energy efficiency for the resulting power electronics systems and related drives; iv) major cost reductions thanks to the dual use of parts, subsystem modularity, and model-based design to eliminate overengineering; and v) increased dependability and reliability of the power electronics systems, enabled by design and intelligent predictive health monitoring algorithms.Through HighScape, the participants will establish new knowledge and industrial leadership in key digital tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enabling the scalable and cheap production of efficient and stable organic-based photovoltaic technology realized via printing techniques, for electricity generation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The reduction of greenhouse emissions is currently acknowledged as a major European objective, and by 2040 a 40% emissions cut is expected, with renewable sources contributing up to 27%. In this respect LAB&FAB aims at developing the fabrication of efficient, cheap and stable organic photovoltaic (OPV) technology printed on flexible substrates, which will be scalable and eventually transferred from a lab-environment to production line. LAB&FAB action will spread on the two parallel fronts: the pilot-scale on one side, and the lab-scale on the other. At the pilot-scale, LAB&FAB will exploit state-of-the art printed OPV modules to push their efficiency, while doubling their lifetime by the end of the project. Long-term stability tests will be carried out and allow for a complete durability assessment, while technological improvements will be introduced to target the efficiency/lifetime goals, as specific weaknesses will be spotted. At the lab scale, novel and efficient materials will be thoroughly explored and characterised and optimised printing protocols will be established for their subsequent integration into solar cells large-area production. Degradation tests will also help assess the materials/devices performance, and at the end of fellowship new efficiency/lifetime benchmarks for such scaled OPV cells will be set.The Experienced Researcher (ER) acquired a solid background on physics of OPV, and thanks to this fellowship she will capitalise and expand it toward more technologically-based challenges related to its technology upscaling. The Host Institution ENI (Italy) is embracing a full transition toward a low-carbon scenario, and thanks to the multidisciplinary aspects of LAB&FAB (covering physics, device engineering, and intellectual property management just to n