RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Combination therapies for personalized cancer medicine.'.

assistant: **Concept**

All cancers arise due to alterations in their genomes. Although insight into the genetic lesions in tumours by genome sequencing does already assist in selecting some drug regimens, it rarely results in disease eradication due to the emergence of drug-resistant clones.  More sophisticated combination therapies in which several oncogenic pathways are targeted simultaneously or in a particular sequence are believed to hold more promise. However, at present we are unable to extract and interpret the necessary information from tumours to predict which drug regimen will be most adequate. The genetic make-up of the individual, the heterogeneity of the tumour, epigenetic alterations, cell-of-origin of the tumour, and complex interactions between tumour cells and stromal cells appear important confounding factors influencing response. In addition, we are still ignorant of many of the intricate complexities of signalling networks in cells and how tumours exploit these to acquire drug resistance.It is the ambition of the team formed by members of the Netherlands Cancer Institute (NKI) and the Cancer Genome Project at the Wellcome Trust Sanger Institute (WTSI) to unravel the genomic and phenotypic complexity of human cancers in order to identify optimal drug combinations for personalized cancer therapy. Our integrated approach will entail (i) deep sequencing of human tumours and cognate mouse tumours; (ii) drug screens in a 1000+ fully characterized tumour cell line panel; (iii) high-throughput in vitro and in vivo shRNA and cDNA drug resistance and enhancement screens; (iv) computational analysis of the acquired data, leading to significant response predictions; (v) rigorous validation of these predictions in genetically engineered mouse models and patient-derived xenografts. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Land protection by improvement of Dike construction', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Flood disasters account for about a third of all natural catastrophes throughout the world (by number and economic losses) and are responsible for more than half of the fatalities. Trend analyses reveal that major flood disasters and the losses generated by them have increased drastically in recent years. For this reason it is important to take appropriate steps without delay.On the one hand, the efforts that are being taken to combat climate change must be stepped up, while on the other hand we must pay m ore attention to flood protection and loss minimisation or prevention. These disasters could be significantly attenuated by improved technical flood protection. One main part of flood protection is the dike rehabilitation of existing dikes (some of them we re built more than 150 years ago) as the majority of existing dikes do not fulfil the existing safety standards. Existing dike rehabilitation techniques are quite often expensive with a limited field of application.The proposed PRODICON system will target this problem as it intends to develop a universal dike rehabilitation technology applicable to all types and states of dikes. The PRODICON technology is an innovative and economical technology for dike rehabilitation due to the onsite and in-situ preparation of the novel dike sealing material. By applying the PRODICON technology during dike rehabilitation transport processes can be minimised significantly.Beside the material development the PRODICON project aims to develop a novel technique for the application of dike sealing material. The novel technique can also be applied to wetted and softened dikes where the usual technologies must fail due to heavy construction machines - this could be seen very impressive during and after the recent flood disasters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Simulation-based Protein Engineering with Transferable Implicit Transfer Operators' in the context of a Horizon Europe call.

assistant: **Objectives**

Minute changes in proteins—such as a single amino acid substitution—can profoundly impact cellular function. A computational model capable of systematically mapping the relationship between protein sequences, their dynamics, and their interactions with other biomolecules would revolutionize biology and enable rational, physics-informed bioengineering applications. SPETITO outlines the methodological foundations for such a framework.Recent advances in deep generative AI (GenAI) have enabled surrogate methods for efficient molecular dynamics (MD) simulations, tackling the challenge of sampling rare events and conformational transitions. The PI co-developed groundbreaking methods—Boltzmann Generators (BG) and Implicit Transfer Operators (ITO)— that enable the study of conformational changes, protein folding, and prediction of experiments five orders of magnitude faster than MD.However, these methods cannot generalize across molecular systems nor scale to larger molecules, severelylimiting their utility. To address this, we propose developing and disseminating transformative technologiesthrough widely accessible software:• A transferable ITO (TransITO) model that captures universal protein physics, enabling rapid samplingwith microsecond-time-steps for any protein system without requiring system-specific training data.• A ‘protein sequence gradient’-based optimization framework, enabling efficient exploration and optimization of protein sequence space for targeted functional outcomes.• An automated protocol for protein design that integrates multiple thermodynamic constraints, facilitating the rational engineering of proteins with desired properties.Beyond turbo-charged atomic-resolution insights into biophysics, TransITO will enable rational, physics-informed protein engin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Between Sea and City: Ethnographic explorations of infrastructure, work, and place around leading urban container ports' (Ports) under Horizon 2020.

assistant: **Objectives**

How to study the turbulent transitions and risky mobilities of global capitalism today? An illuminating, but often overlooked site that lends itself to explorations into the changing nature of our economic system can be found at the interface between sea and city, i.e. at the port. Container ports have often been pushed to the edges of the urban spaces that they used to be centrally located in. A study on the city/sea-nexus will illuminate the dynamics behind the ways in which the center of global capitalism is currently on the move east-wards. This is not a uni-linear shift from “the West” to “the Rest”, but rather, is brought into existence by the nature of the ever-changing interplay between local territorialization and global connectedness. By investigating the relationship between port and city, PORTS will achieve three objectives: 1. to uncover the daily practices that port-related infrastructures enable in order to ensure the flow of commodities travelling through them; 2. to document the ways in which workers employed in the orbit of the port are affected by, and relate to, race-to-the-bottom-dynamics within the maritime world; and 3. to analyze the gradual move of the port away from the city center, and the urban waterfront changes that come with it, and how these are experienced, discussed, and justified by various stake-holders. PORTS will engage with local histories, unruly presents, and possible futures in four of the most important port-cities in the world: Singapore, Pusan (Korea), Rotterdam (Netherlands) and Piraeus (Greece). Through ethnographic work, it will clarify the changing nature of work, the significance of “place” as a site of accumulation and resistance, and the role of infrastructure for the inner workings of ports. Given the dearth of work a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Supporting the roofing SMEs in the development and use of a new generation of roofing materials applicable with fault tolerant procedures, reducing the use of petroleum-based products' (NU-ROOF) targeting Seventh Framework.

assistant: **Abstract**

One of the most important and costly operations in the construction and maintenance of a building is the insulation of the roof.  Current materials used in the application procedures for waterproofing are applied with heat, locally melting the edges to create a continuous impermeable layer. This procedure highly depends on the operators’ skills and it is prone to error and potential leakages. It is also noted that traditional membranes are impregnated with high temperature resistant resins and additives and this creates problems for the environmentally safe recycling of these materials.Standardization, the cross pollination of best-practices, and the ability of innovative SMEs to bring products to market are extremely problematic in the roofing industry.  The value chain of roof insulation is almost totally based on the work, technical experience and skills of SMEs.  Roofing associations represent these SMEs and are responsible to introduce new and novel products into standards.The overall objective of NU-ROOF is to develop an innovative and new generation application of roofing approaches, aimed at ensuring advanced roof insulation while improving the work environment, and enhancing energy efficiency and recyclability, reducing the use of petroleum based products. The project will address the needs of their member SMEs operating in the roofing sector (contractors and material suppliers) to access new multifunctional materials and installation procedures for roof insulation, that could improve their competitiveness and make this step in the construction process easier, safer, more fault tolerant, more energy efficient, and more profitable for all interested parties.The project will provide roofing Associations and SMEs with a collaborative knowledge-based platform to pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Nanobiotechnology for the coating of medical devices'.

assistant: **Objectives**

Surfaces of medical materials and devices that come into direct contact with human tissues need to be fine-tuned with regard to both physical and biological properties. A cross-disciplinary nanotechnology approach is proposed that aims to impart material surfaces with appropriate biological properties. This approach gathers competences from across Europe and includes a critical mass of resources necessary to accelerate the R&D process. The biomolecules that are to be grafted onto surfaces to functio n as nanocoatings have been selected from a class of complex polysaccharides, the pectic rhamnogalacturonans, that are known to possess anti-inflammatory properties as well as desirable physical properties. Sugar molecular structure will be altered in a controlled manner so as to favourably influence living cell behaviour around the coated materials. Current knowledge and expertise within our project team covers technologies to manufacture a range of tailored polysaccharides, to attach the molecules co valently to relevant biomaterials (e.g. titanium for dental implants) and to characterize the grafted surfaces and to assess their biocompatibility both in vitro and in vivo. We expect to generate evidence demonstrating both the antiinflammatory and mole cular flexibility of the innovative nanocoatings. This will open a platform for the development of a large range of applications that will be defined through industrial guidance and result in solutions for current bioincompatibility problems of various i mplantable devices. Industrial monitoring and engineering will allow the exploration of a wide range of applications (breast implants, meshes etc.). For one of these: the dental application, the involvement of industrial SMEs covers the full production c hain from raw material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'NEUROBIOLOGY OF EPILEPSY GENES'.

assistant: **Objectives**

Ion channel genes have long been linked to Mendelian focal epilepsies, but my recent finding of frequent mutations in DEPDC5 opens completely new perspectives. DEPDC5 is an inhibitor of the mTORC1 (mammalian target of rapamycin) signaling pathway, the master regulator of cell proliferation and growth. Mutations of this gene are found in a wide spectrum of focal epilepsy syndromes, with or without cortical malformations. I propose to examine the links between DEPDC5 and the mTORC1 pathway in cortical development and the genesis of epileptic activity. My proposal work will combine high-throughput sequencing, in vivo proteomics, biochemistry, electrophysiology, and animal behavior testing (video-EEG). Functional analyses will be made on human postoperative tissue and neuronal cultures from human iPSC and specific rodent models. These approaches will enable me to (1) ask if and how the mTORC1 signaling pathway may contribute to epileptogenesis and seizures in patients with DEPDC5 mutations, (2) attempt to explain the diversity of phenotypes, in particular the presence of cortical lesion by searching for somatic brain mutations in the gene, (3) explore neurobiology pathways and partners of DEPDC5, and (4) identify novel actors for inherited focal epilepsies.Our results will help us understand the genesis of epileptic networks, and more generally how defects in mTORC1 signaling cascade cause neurologic conditions. We anticipate genetic studies on germline and somatic mutations will have a significant clinical impact for genetic counseling and improved prognosis. The molecules and pathways that will be studied in this proposal differ completely from ion channels and receptors that have been so far associated with focal epilepsies. Thus I hope to provide a new orientation for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dissemination of Environment and Transport Telematics Results and Needs Analysis in Central and Eastern Europe' in the context of a Fourth Framework call.

assistant: **Objectives**

The project will organise a diffusion event for EU RTD Telematics Application Programme (TAP) results. The conference will be organized as a joint effort of the International Society for Environmental Protection (ISEP), Austria, the Regional Environmental Centre (REC), Hungary, and the Research Centre Karlsruhe (FZK), Germany and shall take place at the REC's conference facility in Szentendre/Hungary.The immediate objectives of the conference are to:- present the results of Telematics projects in the fields of environment and transport (transport projects of environmental relevance)- facilitate the possible uptake of TAP results in CEE- discuss the needs in CEE for Telematics related technologies and the problems associated with their implementation - outline existing Telematics initiatives/ success stories in CEE - introduce the Telematics Applications Programme (TAP) in CEE.The conference's longer term aim is to pave the way for the involvement of CEE countries in future Telematics RTD calls and to encourage the adoption of Telematics related applications in CEE, thereby assisting the countries of the region to become part of the broader European 'information society'. A secondary objective is to improve the state of the environment and the management of transport by raising the standard of information related activities such as monitoring, mapping, storage and dissemination of environment and transport information. Presentations at the conference will be published as proceedings and made available on the internet. Furthermore, feedback from conference participants to Telematic issues will be recorded (during roundtable discussion and with an evaluation form). A summary of the evaluation form/roundtable discussion will be produced subsequent to the conference. Major V
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'International trade, economic geography and multinational firms' in the context of a Fourth Framework call.

assistant: **Objectives**

The aim of the research being outlined in this proposal is to investigate how the presence of multinational firms in models of international trade can impact upon patterns of trade and specialisation in integrating regions. The research will do this by building on existing work in trade and imperfect competition. There are two components of the research project. The first is to develop theoretical models of international trade which allow for multinationality and which focus on issues of economic geography. The second is to extend existing computable general equilibrium models to allow for the existence of multinational firms. The training content will be to increase both my general knowledge and abilities as an economist, an a secondly to increase my skills in my area of expertise. The applied part of the proposal has a direct link to industry by being concerned with analysing changes in specific manufacturing sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sulfonates in terrestrial environments' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Aromatic sulfonates are synthetic compounds that are widely used in European industry and households, in applications as diverse as detergents, pharmaceuticals, tanning agents and cement additives. Although these chemicals are regarded as xenobiotics, and accumulate in certain environmental compartments, natural sultonates of unknown structure also make up a large proportion (>50%) of the sulfur in forest and agricultural soils. The SUITE project will investigate the desulfonation of synthetic and natural sulfonates by aerobic and anerobic bacteria in soils from various European climate zones, and relate this to the sulfur status in the soils studied and to sulfur cycling in soil organic matter. This emphasis on the sulfur cycle is a novel one in biodegradation/bioremediation studies, and will provide a model for investigations of other sulfur-containing xenobiotics in the environment. In addition, by characterizing the structure and cycling of naturally-occurring sulfonates for the first time, SUITE aims not only to achieve an understanding of sulfur cycling which will be of value in agriculture and forest management, but also to link microbial processes in uncontaminated environments to potential bioremediation problems throughout Europe, for predictive and management purposes. The main objectives of the project are: 1) Characterization of the desulfonation enzymes and their genes in aerobic and anaerobic bacteria, and development of new methods (RT-PCR) for direct analysis of the expression of these desulfonation genes in various soil environments. The soil environments tested will include:  a) uncontaminated soils (pristine soils"), representative of the different climatic conditions of Europe on a north-south gradient from North Sweden to Italy, and carrying differ