RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cell migration is centrally involved in embryonic development, regeneration and immune surveillance. However, when misguided it also contributes to the pathogenesis of Europe’s socioeconomic most relevant diseases including cancer, cardiovascular diseases and chronic inflammation. Accordingly, better understanding the fundamental mechanisms of cell migration is of direct clinical relevance. In order to migrate within a multicellular context, cells have to negotiate physical constraints, such as other cells and the extracellular matrix and effectively integrate mechanical challenges into directional decision-making. This proposal suggests a combined cell biological and biophysical approach to provide a quantitative understanding of the underlying molecular and mechanical principles. We will focus on the prototypic force-generating structure of migrating cells the lamellipodium - a flat sheet-like protrusion of dendritic actin networks at the leading front of migrating cells. We will decipher the ultrastructural adaptations of lamellipodial actin networks with single filament resolution and characterize how nucleation, elongation, depolymerization and crosslinking of actin filaments coordinate circumnavigation of mechanical obstacles. Technically, these questions will be addressed in a multidisciplinary approach by employing correlative fluorescence and electron tomography in combination with artificial environments engineered using microfluidics and substrate micropatterning, as well as genetic approaches and biological modelling. Importantly, findings will ultimately be challenged in living tissues. The expected results will generate an integrated view of force-adaptations of actin networks in living cells and will not only impact the fields of cell biology and biophysi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced Safe Separation Technologies and Algorithms' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Air transport throughout the world and particularly in Europe is characterised by major capacity, efficiency and environmental challenges to improve performance. It is time for the 'paradigm change' called for in the GOPVision 2020 report on Air transport. ASSTAR addresses this critical issue by researching and validating two specific areas of ASAS. Package II that have strong potential for near term operational and environmental improvements.ASSTAR brings together a powerful team of European ATM researchers, industry and, in particular, airlines and ATS providers, to evaluate the following subset of the ASAS Package II airborne separation applications:-The delegation of conflict resolution manoeuvres to the air, in radar controlled airspace (ASAS crossing and passing) in order to reduce controller workload and improve flight efficiency.-The use of ADS-B to support new operations in non-radar airspace. This will enable more optimal routing including enhanced use of wind corridors and passing and level changing that are currently severely restricted due to the procedural separation standards.Combining these two areas in the ASSTAR project will harness the considerable expertise and skills of the consortium and ensure that the solutions will be operationally viable and functionally applicable. This significant objective will be confirmed by the series of project workshops and user forums.The work will build on the identification of scenarios with potential benefit in order to direct the two distinct activities of definition and validation of the non-radar and radar algorithms and operations. These two themes will be brought together in a comprehensive procedure associated with air and ground implementation requirements.In addition, key safety assessment tasks will deliver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Environmentally complying plastic components moulding and surface treatment technologies (CLEANPLAST)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Plastic components are being more and more used in the automotive sector since they represent a way for weight reduction, cost reduction and flexibility in design and manufacturing. Manufacturing and eliminating plastic components are processes with low environmental compatibility. The project objective is to develop design, manufacturing and dismissing technologies for plastic components to reduce the environmental impact during the life cycle of the product. Research is finalised to virtual design, polymers development, new moulding process with gas injection, innovative surface treatments. A continuous activity of industrial and environmental impact assessment will be carried out, in order to address the research, validate the results and give an orientation for future industrial implementation of the new technologies.Concerning the cars market, the activity is focused on:- to increase the competitiveness of Europe;- to reduce the environmental impact;- to improve the knowledge in all plastic chain applications (polymers-software-moulding- chromium-painting).In the market research we had shown that the main increasing markets are outside the western world and unfortunately the people living there has not the possibility to buy medium or luxury cars. For this reason we think to obtain the same quality through saving costs; (in facilities dedicated units near car makers) in agreement with this the use of electrostatic and/or electrocondutictive polymers seems one of the solution. To reach this target all lab and samples will be involved in the project and we are confident to success in as we have a factory in Poland, we are working in Turkey and we are global supplier of the most important car makers GM-VW-FIAT-BMW.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Advancing Research at the Intersection Between Gut Microbiota and Cancer Cachexia to Train Europe’s Future Leaders in Microbiota Medicine'.

assistant: **Innovation**

Microbiota medicine is the new frontier in human health. The human gastrointestinal tract is home to trillions of microbes. Under normal conditions, these microbial communities drive physiological and homeostatic functions in the host; when altered, they can lead to severe disorders. With an increasingly recognized role in health and disease, the gut microbiota offers promising therapeutic and diagnostic potential to tackle various pathologies (incl. metabolic, neurological, and cardiovascular disorders). Its full clinical potential remains largely unrealized though, mostly due to the lack of critical mass capable of integrating the multiple scientific and translational dimensions of microbiota medicine. Grounded on a team of 180leading researchers and entrepreneurs from across 12 countries and dispersed disciplines (biological big data analytics, systems and synthetic biology, experimental and translational medicine), MiCCrobioTAckle will train 12 Doctoral Candidates (DCs) with the much-needed cross-disciplinary and -sectoral expertise to advance microbiota medicine. As course-setting disease, the DCs will focus on cancer cachexia (CC). CC is an excellent model to study the host-microbiota axis in the context of metabolic diseases and represents the paradigm of a devastating condition in urgent need of new and more efficient means of clinical management. Along MiCCrobioTAckle, the 12 high-calibre DCs will foster new discoveries with impact on CC, while driving scientific and technological progress in microbiota medicine in its broadest scope. By training the next generation of researchers with out-of-the-box thinking and an entrepreneurial mindset in microbiota medicine, MiCCrobioTAckle will safeguard the EU leadership in this vanguard and imperative biotech/pharma seg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Images in Exile:Gender and representations among Syrian Kurdish women in Norway' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project Images in Exile (IMEX) addresses the current refugee crisis and its implications for Syrian Kurdish women in Europe. It challenges images about Muslim women, who are often the subject of debates on the supposed dichotomy between an imagined secular progressive West and religious backwards East. Kurdish women disrupt this dichotomy through an alternative portrayal in global media. Whereas Kurds were previously often pictured as terrorists, backward, and conservative, they are now presented as courageous fighters against, and victims of, Islamic terrorism; and as progressive forces that include women in their ranks. Ideas about progressive, feminist and secular forms of governance are strongly developed in Kurdish political thought, and central in local self-representations.However, media representations and political ideology often differ from social realities on the ground. Going beyond these representations, this study will investigate Kurdish women’s experiences in a rapidly changing socio-political context. It aims at developing better insights into migrant women’s integration and participation in European societies. IMEX thus directly responds to an important policy priority of the H2020 work programme, and targets a better gender and equality balance.Building on extensive research experience in the Middle East and Europe, and the knowledge of Kurdish, IMEX will carry out field research among refugees and migrant organizations in Norway. Methods include narrative interviews with 40 women, focus group interviews, and action research through the set-up of a photo exhibition. The host organization is the Centre for Gender Research at Oslo University, a leading Gender institute in the Nordic region. Dissemination is directed towards high academic quality and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'AdvanCing UAVs teChnology to EnabLE monitoRing for A susTainable environmEnt' (ACCELERATE), addressing dissemination and exploitation.

assistant: **Impact**

Unmanned Aerial Vehicles (UAVs) are emerging as powerful tools for sustainable environmental monitoring, playing a vital role in comprehending the diverse effects of climate change on ecosystems. The integration of state of the art techniques such as Artificial Intelligence (AI) with UAV technology has introduced innovative pathways for various environmental applications. However, their full potential remains to be explored. ACCELERATE proposes the development of a fertile inter-discipline and inter-sectoral ecosystem that aims to radically contribute towards enhancing UAV technology to enable the sustainable environmental management. The specific objectives of the project are to: a) Create a continuously updated ecosystem with UAV datasets suitable for environmental studies and climate change impact assessment, b) promote methodological advances in the field of UAVs technology, by exploiting the unique capabilities of those data with state-of-the-art techniques and c) establish clear guidelines and homogenized protocols for the characterization of the exploitation of UAVs in specific application domains. Experimental analysis will also be carried to showcase the practical use of the project outputs via four carefully selected and innovative Use Cases, that will serve as Key Performance Indicators of the project. ACCELERATE brings together enthusiastic staff from academia and industry via a series of carefully-designed secondments, establishing a unique fertile collaborative research and innovation environment to promote pioneering research in environmental and socioeconomic studies implementation within urban, natural and agricultural environments. A strong inter-sectoral experienced research team of 17 partners from 9 countries, of 8 academic and 8 industrial partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Defining the role of FBXW7 in intestinal epithelium regeneration'.

assistant: **Concept**

Inflammatory bowel disease (IBD) is a severe disorder affecting millions of people in Europe, characterised by chronic flares of intestinal inflammation and causing tissue loss or malfunction. Currently, the available treatments can only reduce symptoms. New regenerative therapies promoting epithelial functionality are highly needed. Several studies report how upon damage, progenitors or more committed cells re-acquire stemness properties and foetal-like signatures to restore intestinal homeostasis. However, it is still unclear how such regenerative response is modulated and how cells revert to their adult state. Preliminary data from the host lab indicate that loss of expression of FBXW7 protein, member of a E3 ubiquitin ligase complex, reinforces cells in the foetal-like state. Interestingly, FBXW7 mutations are under positive selection in IBD patients. Thus, I propose that upon injury, cells lacking FBXW7 maintain a foetal-like state, where they are refractory to terminal differentiation, increasing the risk of aberrant tissue restoration. To test my hypothesis, I will exploit state-of-the-art in vivo and in vitro models of intestinal regeneration and make use of forefront technologies, such as CRISPR, high-content imaging, mass spectrometry and single cell RNA sequencing. This will allow me to 1. characterise FBXW7 impact on intestinal regeneration, 2. define FBXW7 mode of action in human intestinal cells, and 3. identify FBXW7 substrates as potential targets to restore tissue homeostasis. By addressing these points, it will be possible to obtain key insights into the mechanism of intestinal regeneration and identify ways to efficiently induce and control tissue repair in IBD patients, avoiding the expansion of unrestrained proliferating foetal-like cells. Important
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Progressing Wave Energy Conversion via Large-Scale Additive Manufacturing'.

assistant: **Objectives**

Wave energy conversion by harnessing untapped ocean resources has the potential to significantly expand the European renewable energy production and portfolio. However, high development costs, complex manufacturing processes, and low technology readiness levels have hindered the commercial scalability of wave energy converters (WECs). The WEC-Pro project seeks to address these challenges by leveraging cutting-edge Large-Scale Additive Manufacturing (LSAM) technologies to streamline the design, production, and testing of WECs. LSAM coupled with adapted optimization tools has the potential of reducing device’s costs by over 10 times. WEC-Pro will take advantage of the strong expertise of Politecnico di Torino in WECs optimization and Europe’s principal LSAM production centre, Caracol, to develop and adapting WEC modelling tools for LSAM application. For the use of the sustainable and fast LSAM, enabling the development of highly efficient and cost-effective devices, it is required to integrate new parameters in form of constrains to modelling tools. WEC-Pro’s primary goal is to integrate required LSAM parameters and upgrade established methods, design and optimization processes for WECs R&D scope. Key challenges of multi-parameter performance design, structural optimization, physical testing and LSAM production of WECS are addressed in three dedicated work packages, respectively. For demonstration, WEC-Pro covers two high-potential case study technologies, PivWEC (near-shore) and PeWEC (offshore), by testing for the first time fully-LSAM produced WECs physical models at Italy’s largest and most advanced Seakeeping tank (INSEAN, Rome).The planned outcomes include the development of open-source tools and models for WEC’s power absorption, structural optimization and data se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Translocation and Safe Design of Surface Engineered Metal oxide Nanoparticles' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of “safe by design” is based on the application of nanosafety to design the nanomaterials in order to prevent or reduce their possible harm to humans and the environment. The project encompass the synthesis of metal oxide NPs, with a focus on magnetic oxides, their surface modification and post modification in biological fluids; immunological and genotoxicity studies, and translocation studies both “in vitro” and “in vivo”. The project will seek to establish relationships between designed NP properties and their translocation at cellular and body level as well as their immune- and genotoxic response. This is a fundamental issue for the safe design of NPs. Also, the toxicological response will be studied as a function of the uptake dose of NPs. At cellular level a battery of techniques will be applied for localization and quantification of NPs: Transmission Electron Microscopy, Raman, Confocal Microscopy, Ion Beam Microscopy, etc. Positron Emission Tomography and Magnetic Resonance Imaging will be employed for biodistribution and quantification studies in animal models. BRASINOU is formed by an international team with the required and complementary expertise to address the proposed work from an international and multidisciplinary perspective. The project gathers internationally recognized groups in immunology, genotoxicity, nanoparticle synthesis, surface chemistry, biophysics, imaging and mater
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Holistic Benchmarking of Big Linked Data' (HOBBIT).

assistant: **Innovation**

Linked Data has gained significant momentum over the last years. It is now used at industrial scale in many sectors in which an increasingly large amount of rapidly changing data needs to be processed. HOBBIT is an ambitious project that aims to push the development of Big Linked Data (BLD) processing solutions by providing a family of industry-relevant benchmarks for the BLD value chain through a generic evaluation platform. We aim to make open deterministic benchmarks available to test the performance of existing systems and push the development of innovative industry-relevant solutions. The underlying data will mimic real industrial data assembled during the course of the project. At the beginning of the project, HOBBIT will work on roughly 1PB of real industry-relevant data from 4 different domains. The data will be extended through collaborations during the project. To push the use of the benchmarks, we will organize or join challenges that aim to measure the performance of technologies for the different steps of the BLD lifecycle. In contrast to existing benchmarks, we will provide modular and easily extensible benchmarks for all industry-relevant BLD processing steps that allow to assess whole suites of software that cover more than one step.The infrastructure necessary to run the evaluation campaigns will be made available. Our architecture will rely on web interfaces and cloud infrastructures to ensure scalability. The open HOBBIT platform will make human- and machine-readable, public periodic reports available. As exit strategy, the project will create an association after the second project year that will be sustained by the means of subscriptions from industry and academia and associated with existing benchmarking associations. The clear portfolio of added v