RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improvement of the quality and safety of fermented beverages through the management and control of spoilage microorganisms' in the context of a Horizon Europe call.

assistant: **Objectives**

SpoilControl will train the next generation of polyvalent researchers in the field of sustainable fermentation technologies, able to meet current and future challenges created by microbial spoilage and improve the quality & safety of fermented beverages.Europe is the historical leader of fermented drinks, whose competitiveness is intensively challenged. Microbial spoilage in fermented food is a growing concern from a financial viewpoint (economic losses) and from a health perspective (increasing presence of pathogens, particularly in improperly homemade or artisanal productions). Such quality & safety issues are amplified by societal and environmental changes: the consumer trend toward low-input products, sustainable practices, small-scale productions and climate changes are associated with increased risks of microbial spoilage. In addition, the fermentation sector cruelly lacks a global framework & training between beverages, resulting in efforts duplication & investments partitioning.SpoilControl will unfold an original strategy based on multiple beverages (wine, spirits, beer, cider, kombucha, kefir), multiple disciplines (from environmental & life sciences to engineering or economics), multiple solutions (development of sustainable biological, chemical and physical treatments). The consortium covers the whole fermentation chain from Fermentation to Glass with 34 partners including universities, SMEs, large companies, innovation cluster, start-up, analysis laboratories, technical institutes and homebrewers’ group.SpoilControl will have multiple impacts: at the scientific level, the study of non-conventional microbial species will be useful besides the fermentation sector; at the societal level, SpoilControl will improve public awareness of safety issues in fermented
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Conventional Dendritic Cells – Ecology, Diversity, and Function', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Effective T cell responses are critical for the efficacy of vaccination and cancer immunotherapy; therefore, the manipulation of conventional dendritic cells (cDCs) offers great potential for improved therapies as these cells play a key role in the activation and regulation of T cell function. However, cDCs are a diverse group of cells whose function is incompletely understood. Previous attempts at targeting cDCs therapeutically have been underwhelming perhaps as a result of not targeting the right cell subset specifically. The goal of this proposal therefore is to reveal the functional properties of the different cDC lineages during type 1 and type 2 immunity and to understand how the ecology of cDC subsets is regulated to meet the functional demands of tissues undergoing different types of inflammation. I propose that studying the cDC subsets that enhance cytotoxic T cell responses against viruses in type 1 immunity and those that enhance parasite clearance and tissue repair in type 2 immunity against nematodes will help to identify those cDC subsets that need to be either triggered or inhibited to improve tumour control. Therefore, we will use well-defined models of type 1 and type 2 immunity to reveal the diversity of these cells during inflammation. Furthermore, we will generate new mouse models to target cDCs subsets specifically to study their functional properties and to reveal how these functional properties are instructed. In this regard, we will address how subset specification is regulated distally, by a novel inter-organ communication axis (lung-bone marrow) that could tune the host immune system to ever-evolving challenges. Finally, as a proof of concept, we will use transplantable and orthotopic cancer models to unravel beneficial and detrimental cDC subs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Combined low-temperature gasification and combustion' to be submitted under Fourth Framework.

assistant: **Abstract**

Project Objectives The aim is to verify - theoretically and on a pilot scale - the function of a novel low-temperature biomass gasification technology and associated combustion system. A 3 - 4 MWTH fuel input system for straw with high inorganic ash content (straw with 4 - 6% ash content) will be designed, built and tested for at least 100 hours based on a combination of laboratory experiments and engineering know-how. Components for a full scale system - 30 - 50 MWTH - will be designed and a systems synthesis for 3 different European countries, including environmental aspects for the emission of solids (ash/particles), liquids (water soluble minerals) and gases (especially NOX), will be prepared. Technical Approach The core of the process is a specially designed reactor tube, where compressed - cut - straw during axial transport are subjected to radially introduced gasification mediae (air or mixture of air and flue gases) at an elevated temperature. The ensuing pyrolysis and charring processes are controlled at a temperature level (in the range 400 - 600OC), where chlorine compounds are retained in a solid phase. The pyrolytic gases and the solid phase are subsequently separated (a mixture of approximately 50% gas and 50% char - calorifically - is expected) and the solid phase - after a washing operation (to remove inorganic compounds - 80% removal is foreseen) - is finally burned with the pyrolytic gases in a specially designed combustion system. Therefore, the resulting flue gases after combustion will basically be clean and suitable for heating stand alone power boilers and also for biomass cofiring with fossile fuel in central power plants. The gasifier and associated feeding system and the combustor will be tested in a pilot plant and software for the simulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ApTOLL: An innovative neuroprotectant to reduce brain damage in Acute Ischemic Stroke (AIS)' (AIS).

assistant: **Concept**

Stroke is a devastating medical condition affecting 15 million people worldwide yearly, being Ischemic Stroke the most frequent (87%). Indeed, the global cost of stroke is >847b (60b in EU) due to the huge socioeconomic burden of disabilities. Reperfusion treatment improves outcomes, but only 20% of patients are currently eligible for treatment due to the narrow therapeutic window after stroke symptom onset and stringent selection criteria for eligibility. Novel therapies - small molecules or biologics - targeting neuroprotection have not achieved enough efficacy to get approved. aptaTargets has successfully developed ApTOLL, an immune modulator and neuroprotectant with a novel approach TO REDUCE BRAIN DAMAGE in AIS patients. aptaTargets ApTOLL drug has a novel approach targeting TLR4 to reduce brain damage in acute ischemic stroke (AIS) patients (47% reduction of FIV), reduce mortality from 18% to 4% and improve functional outcomes. Due to the innovative MODE OF ACTION AND NATURE of the molecule (an aptamer), ApTOLL represents a novel and disruptive approach to treating stroke in the first hours after the onset (acute phase), substantially reducing brain damage and improving Quality of Life (QoL) in short and long time.ApTOLL is targeting the Multi-Billion Market of the global Stroke Management Market, valued at 31.7Bn in 2020 and expected to reach 67.7Bn in 2030 (7.8% CAGR). As a first indication within the scope of this EIC Accelerator proposal, ApTOLL will target AIS patients (87%) who received EVT therapy, expecting to be potentially used as neuroprotectant in all stroke patients, based on preclinical and clinical results. The EIC project aims to conduct the Ph2b trial of ApTOLL and demonstrate its efficacy before entering Ph3. It will boost our chances of licencin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Industrial Doctorate in future efficient minerals analysis, processing and training' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

MetalIntelligence proposes an EID in future efficient minerals analysis, processing and training. Transformational change caused by the third industrial revolution, which itself relies on extraction of raw materials, provides the impetus. A resource-efficient EU is recognised as a societal challenge. However, the pathway from searching for mineral deposits to metal production is complex and involves a number of sectors (geosciences, chemical analysts, mining, processing, metallurgy) that have tended to work in silos. Limited intersectoral collaboration has led to compartmentalised thinking which has become an impediment to improved resource and energy efficiency.The overall aim of MetalIntelligence is to disrupt this compartmentalisation, by training 6 ESRs through a multi-disciplinary network of academic and industry leaders with an exceptionally broad range of expertise and skills. The team comprises three beneficiaries (2 academic, in Ireland and Sweden, and one Industry, Finland) as well as 4 partners (from the UK, Ireland, and Finland) who will provide secondment opportunities and/or industrial supervision.The programme is arranged as work packages (WPs), including management, training, and dissemination as well as three research-driven packages. The first research-based WP aims to improve mineral analysis in preparation for more efficient processing. The second concerns itself with advanced modelling of dynamic minerals processing. The third will research modern, technology-enhanced training for future professionals. The tailor-made training programme consists of network wide components, delivered by industry and academia leaders as well as specific training in the workplace.The objectives of MetalIntelligence were designed to align with European innovation capaci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CONFERENCE ON ALGEBRAIC TOPOLOGY', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The scientific objectives are mainly provided by research themes of the French GDR/CNRS n° 1110 on Algebraic Topology, to which belong the organisers and about 70 French topologists working at PARIS 7, PARIS 13, ECOLE POLYTECHNIQUE, NANTES, LILLE, NICE, STRASBOURG and elsewhere. Our proposed event will follow immediately the Annual Assembly of the GDR at NANTES University. Research of this group is centered on present problems of modern Algebraic Topology, concerning mostly algebraic theories coming from the solution of the SULLIVAN conjecture (like Theories of Unstable Modules over the STEENROD algebra), Homotopy Theories with Models (like Rational Homotopy and Operades), MACLANE homology, Cyclic homology and also Algebraic K-theory. Presently we also open research to more geometric problems on quantum invariants of low dimensional manifolds and knot theory. Typical examples are the relations of VASSILIEV invariants to universal LIE algebras, HOCHSCHILD cohomology and rational homotopy, or foliations and algebraic schemes and L2-cohomology and knot concordance.Our proposal aims to intensify research cooperation of the GDR with two groups of European partners:1) About 40 individual cooperations with topologists in SP Am (Barcelone, Malaga, Santiago, Granada), BELGIUM (Louvain-La-Neuve), ITALIE (Bologne), SWITZERLAND (Lausanne, Neuchâtel) have reached a high level calling for regular research meetings.2) Relations between the Mathematics Departments of NANTES and DUESSELDORF (Germany), organised within the institutional framework of the German-French University (UFA), have led to close cooperation of Topology Seminars of NANTES/ANGERS/VANNES and DUESSELDORF/BONN/WUPPERTAL.We want to associate them closely to our GDR. By organising regular scientific meetings of the resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Condition monitoring and ultrasonic sensing utilising extrinsic fibre-optic interferometric techniques' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Summary-Development of an instrument for detection of broad-band (0.1-1 MHz) low amplitude (0.1 nm) surface displacements using an extrinsic fibre-optic Sagnac interferometer. The instrument is expected to have considerable better performance in terms of spatial resolution and responsivity compared to conventional transducers, and is non-contacting with a uniform velocity responsivity. The instrument is ideal for detecting Acoustic Emission, and find numerous applications in condition monitoring. Various noise sources associated with the instrument will be analysed, and methods for obtaining ultimate performance will be investigated. Theoretical and experimental studies of new wavelength division multiplexing schemes for addressing several intstruments will be performed, and analysis of alternative extrinsic Sagnac inteferometer configurations for distributed sensing applications will be conducted. Novel variants of the instrument for detection of torsional and in-plane surface displacements will be examined both theoretically and experimentally, and a better understanding of high frequency surface vibrations are expected to be obtained.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Worldwide unified scales rockwell hardness test with conical indenter' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Worldwide unified scales should be achieved for all hardness tests using conical indenters (HRC, HRA, HRD, HR15N, HR30N and HR45N). This should be performed by means of metrological examinations of the influences concerning the differences between the values measured on reference blocks and of those obtained from round robin tests. Aim of this project is that for all hardness measurements with conical diamond indenters each laboratory in institutes or in industry will be in the position to produce measuring values of the same magnitude within small ranges. The ISO Committee ISO TC 164 SC3 - responsible for hardness of metallic materials agreed unambiguously at the meeting in March, 1995 to ISO resolution No 158 proposed by two European and one non-European country (all three are proposed to participate in a round robin test under discussion). The ISO resolution corroberates the necessity of the unified hardness scales for the Rockwell scales using conical indenters
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of very promising humanized therapeutic mAbs efficiently neutralizing a novel immunosuppressive pathway involved in a wide range of cancers'.

assistant: **Innovation**

Studies have demonstrated the importance of CD73 in the spread of cancer. Overexpressed in numerous cancer types, this enzyme leads to the production of high amounts of extracellular Adenosine, creating an immunosuppressive microenvironment, and contributing to tumor proliferation and dissemination. Neutralizing its activity represents a highly potent and innovative therapy.Following on the recent success of mAbs targeting immune checkpoint (PD1, CTLA4), TumAdoR aims to discover, characterize and produce humanized anti-hCD73 mAbs that will be assessed for their efficacy and safety in relevant mouse preclinical tumor models. It will result in the development of anti-CD73 drug candidates that will strengthen the immune system, stop cancer cell progression and prevent relapse through restoration of immune memory. TumAdoR aims at paving the way to first-in-human clinical trials of potent mAb candidates, and validating a new cancer immunotherapy, suitable for a wide range of cancers.More precisely, TumAdoR will:•Reinforce knowledge about CD73 role as an immune checkpoint target•Correlate CD73 expression with clinical outcome and validate the tumor patients most likely to benefit from CD73 blockade•Discover and develop mAbs neutralizing hCD73•Develop relevant preclinical tumor models to validate the in vivo efficacy and safety of anti-CD73 mAbs candidate(s)•Develop and standardize tools to assess CD73 expression, and monitor immune parameters in patientsTumAdoR addresses topic 1 by developing antibodies neutralizing CD73, and topic 3 by fighting against immune evasion in tumor host microenvironment. The high-level consortium including 3 SMEs possesses all the scientific and clinical expertises, industrial competences, biological and enzymatic assays, biological and clinical r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The effect of gastrointestinal digestion on the allergenicity of foods' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

We propose a novel in-vitro model of human digestion with gastric and duodenal phase of various specificity (human recombinant enzymes) and added bile salts. It will provide industries & regulators improved food-processing methods of assessing protein digestibility, data on allergen release and changes in allergen city during digestion. Digestibility is part of the risk assessment of novel foods and transgenic selection for introduction into plant foods and relevant to assessing the macronutrient quality of proteins. Food allergens are notably resistant to hydrolysis, can escape digestion, cross the gut barrier and trigger allergic reactions. Current in vitro tests use animal enzymes but do not mimic the complexities of the human digestive tract. The digest will be characterised for allergen city, and at the biochemical level, thus enabling production of high-quality hypoallergenic foods for consumption by the society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'End-to-end Virtual Resource Management across Heterogeneous Networks and Services' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective of the EVANS project is to increase researchers’ mobility between EU countries and China to obtain better understanding of network virtualisation for future Internet infrastructure. In particular, the knowledge transfer, as a result of researcher’s mobility, will focus on the management aspects of the virtualised network resources rather than the virtualisation techniques themselves. As far as the types of network platforms are concerned, there are not only optical networks and IP networks for the core networks that constitute the Internet backbone but also various broadband wireless network technologies for mobile access. In order to provide an end-to-end service solution to end users, wireless mobile access network technologies have to be considered as an increasing number of users use mobile devices to get access to the Internet. The EVANS project aims to investigation into the creation of a network virtualisation environment over a fully heterogeneous network infrastructure and to provide an integrated network management system across different types of network platforms. The project will investigate into two complementary aspects of such an integrated network resource management system: (1) vertical management of virtualised resource for service heterogeneity, which is performed by infrastructure providers, and (2) horizontal management of virtualised resource for network heterogeneity, which is for the interest of service providers.This staff exchange programme will also help develop new research links and deepen and strengthen the current research links amongst the partners and help build up long-term, world-class research in future Internet technology.