RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The european network for vertically acquired hepatitis c virus infection (EPHN)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The EPHN is based on 39 reference centres for HCV infection in pregnant women and their children in 9 European countries. Obstetricians, paediatricians, and experts in virology, immunology, and epidemiology will pool data and expertise to resolve some still unanswered questions on the issue. HCV infected women enrolled at or before delivery and their children will be followed up prospectively to collect clinical and laboratory information (>500 pairs already enrolled). 100 previously identified vertically infected children will also be followed prospectively. This study will allow us to precisely define the risk of vertical HCV infection, timing and correlates of transmission, such as viral load and mode of delivery, the natural history of HCV infection in children, including extra hepatic manifestations, and the identification of early prognostic markers, such as cytokine production and HLA polymorphisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FRET analysis of the spatio-temporal activation of Rho-family GTPases in T lymphocytes' under Sixth Framework.

assistant: **Concept**

Rho-family GTPases are signalling molecules that play a critical role during thymocyte development and T cell activation. The biochemical pathways regulated by Rho GTPases in lymphocytes are not at all understood although their importance is clear.Recently the generation of mice deficient in Rho-family GTPases, their regulators and effectors have revealed functions for these GTPases at multiple regulatory levels, including the coordination of cytoskeletal change, activation of kinase cascades, stimulation of calcium fluxes, and the induction of gene expression. Information about the activation of Rho-family GTPases in T cells has been mainly provided by biochemical experiments, which allow only a global measure of GTPase activation.However, it remains largely unknown when and where Rho-family GTPases are activated during T cell activation induced by various stimuli. Here we propose to use fluorescent resonance energy transfer (FRET)-based sensors to report the spatio-temporal activation of Rho-family GT Pases in living T cells in response to diverse stimuli such as TCR triggering, integrin engagement or chemokine stimulation.We aim to perform this both in wild-type T cells and in T cells deficient in various guanine nucleotide exchange factors (GEFs) that are believed to activate Rho-family GTPases. In summary, this project will provide a better understanding of when, where and how different GTPases are activated in T cells in response to different signalling receptors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Aluminium Scrap: Open access database for impurity levels-microstructure-property and methods to recover properties in high impurity scrap' (AluminiumScrapDbase).

assistant: **Innovation**

Aluminium (Al) alloys are extensively used in transport (28%), construction (35%) and engineering (27%) sectors. The total Al in use is expected to increase from 600 million tonnes in 2013 to one billion tonnes by 2020, thus creating a large metal bank for future recycling use.  Currently primary Al production from bauxite ore is the primary source of Al metal supply to industry. Since primary aluminium production is an energy intensive process and the world's bauxite deposits are limited, the use of Al scrap accumulated from packaging, building, automotive and engineering sectors offers a sustainable solution to secure metal supply. However, the scrap from these sectors has higher levels impurities in particular with iron (Fe). Higher concentration of Fe is detrimental to the mechanical properties due to formation of harmful platelet structures of Fe-based intermetallics. The overall aim for the fellowship is to develop solidification science based methods which enables the use of aluminium scrap alloys to produce high value aluminium products to support the rapid growth of Al. The objectives are (i) To develop methods to tolerate higher iron impurity concentrations in Al scrap alloys using model alloys containing impurities, through enhanced heterogeneous nucleation, intermetallic morphology control and restricting their growth (ii) to understand the solidification behaviour of scrap alloys by attempting to tackle the problem from thermodynamic analysis, engineering the microstructure through various approaches and an in-depth understanding of the behaviour of intermetallics using advanced tools, examine the effect of impurities on properties and to determine micro-mechanical properties of various synthetic iron based intermetallic phases,  (iii)  to build an open acc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease' (EVINCI-STUDY) targeting Seventh Framework.

assistant: **Abstract**

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of “anatomic” imaging, by multislice computerized tomography, combined with “functional” tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive “anatomo-functional” imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from “anatomo-functional” cardiac imaging and “clinical-biohumoral” data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics’ platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Wild Evolutionary Genomics', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

150 years since the Origin of Species, we do not know how natural selection acts at the level of the genome in natural populations in ecological time, but elucidation is within reach. This study will investigate natural selection, and the genome's response to it, in unprecedented detail by combining two resources. The Soay sheep population on the island of Hirta, St. Kilda, Scotland is one of the most thoroughly phenotyped wild animal populations in the world and already the subject of internationally famous interdisciplinary research. The recently developed International Sheep Genomics Consortium 60K chip identifies 38,777 single nucleotide polymorphisms in Soay sheep. We will genotype 5,000 Soays for these SNPs. We will first analyse the data to test the effect of realised relatedness and inbreeding coefficients on trait heritabilities, genetic correlations and inbreeding depression. We predict that all estimates will increase, generating much increased power for more complex studies. Second, we will identify genome regions harbouring quantitative trait loci (QTL) and inbreeding depression and genotype additional sheep at SNPs in haplotypes predicting this variation. We will subject these regions to intensive analyses to understand their genetic effects, the action of selection on them and their response to selection. Finally, we will count the recombination events in each parent during the creation of each offspring and conduct a comprehensive analysis of sources of individual variation in recombination, the first of its kind in a wild population.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Tracing T3SS effectors in vivo during Salmonella infection in the zebrafish model'.

assistant: **Innovation**

Type III secretion systems (T3SS) are sophisticated “molecular needles” that many pathogenic Gram-negative bacteria use to establish infection. Salmonella enterica encodes two T3SS that are able to translocate a number of proteins, called effectors, from bacteria to the cytosol of the infected eukaryotic cell. These proteins manipulate host signal transduction pathways and cellular processes to the pathogen’s advantage. During the last two decades, many studies have importantly contributed to the identification and characterization of many of these effectors. However, the subcellular localization, host target and biological role of an important number of them remain unknown. The majority of findings of T3SS effectors come from studies using surrogate in vitro models, like epithelial cells or macrophages. In these cases, the extrapolation of results to an in vivo scenario is not always possible. On the other hand, important mammalian models to study Salmonella infection, like mice, do not allow tracking the pathogen once inside its host. Here, we propose an innovative approach using the zebrafish (Danio rerio) as a relevant vertebrate model to dissect the biological role of Salmonella T3SS effectors during host infection. Zebrafish embryo model allow for rapid, non-invasive and real-time analysis of bacterial infections. We will take advantage of the small size and optical transparency of larval zebrafish for live-cell imaging of host-pathogen interaction experiments. This approach allows real-time cell-resolution monitoring of T3SS effectors. This will significantly improve our understanding of infectious diseases in an relevant in vivo context. This project not only will stablish a new in vivo model in the hosting laboratory and open new posibilities in the study of T3
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Restoring complete sensory ability for natural walking of amputees' (GoSafe), addressing dissemination and exploitation.

assistant: **Impact**

Lower limb amputees use prostheses that do not restore sensory feedback during walking. The lack of feedback increases the risk of falls of amputee, who lose confidence in the prosthesis, overusing the healthy leg, have increased fatigue, and reduced mobility. Finally, they do not feel the device as part of the body and experience phantom limb pain (pain from the missing limb). Because of these reasons, users abandon the prosthesis, with consequent low reinsertion into the working society. SensArs has developed the solution to these problems: a neuroprosthesis that allows amputees to feel sensory feedback from the prosthesis as from a real leg. So far, 3 amputees have tested its technology. The main goal of GoSafe is to improve the device and finalize a pilot trial proving safety and efficacy. The pilot trial will give insights on potential technology or clinical protocol modifications to go through a pivotal study to get CE mark for the neuroprosthesis. To reach this goal, SensArs will optimize the neuroprosthesis and integrate it with the commercial prosthetic leg of Össur, then will go through preclinical validation and clinical pilot study at UCSC and CHAR with leg amputees. With the clinical pilot study, SensArs will apply for a pivotal study for CE mark (class III device), which will allow commercialization after the project. To guarantee the product market uptake, the consortium will run during the project a study to define the strategy to get reimbursement right after the CE marking. There are no commercial devices similar to the one proposed in GoSafe. The prosthesis restoring sensory feedback will enable users to feel the prosthesis itself as part of the body, to avoid falls, and so to increase confidence in the device, which will reduce counterbalancing movem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Consortium for High-Throughput Research in Rare Kidney Diseases' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts assembled to date (collectively >10,000 patients) with detailed phenotypic information and comprehensive biorepositories containing DNA, blood, urine, amniotic fluid and kidney tissue. The project aims to (1) identify the genetic and epigenetic causes and modifiers of disease and their molecular pathways; (2) define a novel mechanistic disease ontology beyond phenotypical or morphological description; (3) develop innovative technologies allowing rapid diagnostic testing; (4) discover and validate biomarkers of disease activity, prognosis and treatment responses; and (5) develop in vitro and in vivo disease models and apply high-throughput compound library screening. For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (‘functiomics’) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Energy consumption prediction with building usage measurements for software-based decision support' under Seventh Framework.

assistant: **Concept**

The objective of EnPROVE is to develop a software model for predicting the energy consumption of a specific building, with different scenarios implementing energy-efficient technologies and control solutions, based on actual measured performance and usage data of the building itself.The key hypothesis of EnPROVE is that it is possible, from adequate gathering and assessing data on how a structure performs and is being used from an energy viewpoint, to build highly accurate and specific energy consumption models relevant for prediction of alternative scenarios.The EnPROVE software tools will assess the energy-efficiency impact of alternative technologies for which available investment resources can be directed and, thus, support the decision maker finding the optimised set of energy-efficient solutions to be implemented. These results will be tailored to the actual building itself, through automated measurements of the building usage and energy efficiency. Technological solutions will include energy-reducing, -generating, and –storing options, and with user-defined criteria on resources and restrictions, will identify through new prediction algorithms when the return on investment will be realized.By solving these problems, EnPROVE will be able to develop crucial new tools, interoperable with existing CAD or Facility Management tools, to model the energy consumption from monitored data, predict the performance of alternative scenarios and support the decision maker in finding the optimal point for the investment. Compared to current available energy auditing services and prediction tools, it is foreseen that EnPROVE will increase the cost-effectiveness of renovation investments by 15 to 30%.These services will open new business opportunities for both construction compani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development and application of advanced plasma welding techniques for high strength aluminium alloys', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

This project forms an initial investigation into the welding of high strength aluminium a]loys for applications in the automotive and aerospace industries. The study concerns the development and implementation of plasma welding to establish positive control over the weld thermal cycle. Plasma offers considerable flexibility in terms of thermal distribution at the workpiece surface, coupled with a high degree of accuracy and repeatability. Using modelling and control techniques developed in earlier BRITE programmes, it is anticipated that alloys (such as aluminium lithium alloys) normally considered to be 'difficult' to weld will be weldable on a repeatable and reliable basis. Important relationships between operating parameters, process characteristics and mechanical properties will be sought, and statistical models, based on data gathered using through arc sensing techniques will be used to optimise process performance. Responsive control algorithms will be developed to minimise loss of mechanical strength and crack susceptibility whilst producing sound welds
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ConcEpt validatioN sTudy foR fusElage wake-filLIng propulsioN intEgration' (CENTRELINE) targeting Horizon 2020.

assistant: **Abstract**

The CENTRELINE project aims at maximising the benefits of aft-fuselage wake-filling under realistic systems design and operating conditions. The concept realises fuselage wake-filling through a single propulsive device installed at the fuselage aft-end with the purpose to entrain and re-energise the fuselage boundary layer flow, the so-called Propulsive Fuselage Concept (PFC). The aft-fuselage propulsor is driven turbo-electrically with power supplied through generator off-takes from advanced geared turbofan engines in under-wing installation. CENTRELINE will perform the proof of concept and initial experimental validation for a highly promising propulsion-airframe integration approach in order to mature this technology from currently TRL 1-2 to TRL 3-4. Advanced pre-design methods based on high-fidelity numerical simulation and integrated multidisciplinary design optimisation techniques will be adopted in order to produce best and balanced design solutions for the concept. The technological key features will be initially validated through physical experiments including scale-model wind tunnel testing for the overall configuration as well as specialised aerodynamic rig testing of the boundary layer ingesting aft-fuselage propulsor. The proposed research and innovation actions represent the immediate exploitation of results of the highly successful FP7 L-0 project “DisPURSAL” (GA no. 323013). The optimised system technology concept will be eco-environmentally benchmarked against an advanced conventional reference aircraft equipped with aerodynamic, structural, power plant and systems technologies suitable for a potential Entry Into Service (EIS) year 2035, referred to as ""R2035"". The objective CO2 reductions of the concept at integrated vehicular level are -11% against