RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New tools for groundnut aflatoxin control in the sahel regions of africa' (GROUNDNUT-AFLATOXIN) targeting Fifth Framework.

assistant: **Abstract**

The highly toxic and carcinogenic substance Aflatoxin, is produced by a widely spread saprophytic fungus Aspergillus flavus. Aflatoxin greatly reduces the export value of groundnut. In drought-prone regions, the infection is encouraged by terminal drought stress. Breeding programmes, up to now, have failed to create a groundnut cultivar resistant to aflatoxin and of high agronomic importance. The main objective of this project is to identify physiological, biochemical and molecular resistance mechanisms of the host plant in order to improve selection and to develop an integrated system for the prevention and control of aflatoxin contamination in the field. Progress made in widening knowledge on these mechanisms and in particular their relationship with plant water supply will contribute to the development of improved resistant or tolerant varieties, and cultural and post-cultural practices limiting aflatoxin occurrence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Low Temperature Magnetic Force Microscopy Study of Topological Insulators'.

assistant: **Innovation**

The study of topological insulators (TIs) is a budding field that is enjoying a fervor of activity. Recent discoveries show that new physics can exist in semiconductors with strong spin-orbit coupling. The most exotic class of TIs - ""strong topological insulators"" (STIs) - is a new state of matter, the hallmark of which is an odd number of topologically protected surface states. We will search for one of the most profound properties of these surfaces states. This predicted, but not yet observed property, is the topological magneto-electric effect (TME), which does not rely on interactions or many-body physics unlike most other emergent effects in solids. In the TME, an applied electric field induces a magnetic field that is proportional to an odd multiple of the fine structure constant. The TME arises when magnetism on the surface of the sample lifts the topological protection of the surface states by locally breaking time reversal symmetry. This gives rise to a special quantum Hall state. The TME is a fingerprint of that state. It is crucial to determine under what conditions the TME occurs, and whether other effects such as electron-electron interactions interfere with it. A low temperature magnetic force microscope (MFM) is an ideal tool for this project since it allows us to induce and measure both electric and magnetic fields at low temperatures. Guided by a suggestion by Qi et al. [Science 323, 1184 (2009)], we will subject the surface states to a magnetic field for breaking their time reversal invariance. This will give rise to the TME. Subsequently we will determine the magnetic field that is induced by electric charge near the surface of the sample by measuring the forces acting on the magnetic MFM tip. We will probe the TME by studying how it is affected by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nano-resolved multi-scale investigations of human tactile  sensations and tissue engineered nanobiosensors' under Seventh Framework.

assistant: **Concept**

The main scientific aims are to radically improve understanding of the human mechanotransduction system and tissue engineered nanobiosensors. This will be achieved through systematic integration of new developments from converging scientific areas by involving academic and industrial participants who are experts in cognitive sciences, microneurography, brain imaging, cell biology and mechanics, tissue engineering, skin physics (tribology and mechanics), microengineering, multi-scale multi-physics modelling, information processing, robotics, prosthetics and medical rehabilitation. The project will build on existing discriminative touch research in order to understand affective touch mediated by the human fingerpad. Sensors capable of detecting directional force and temperature will be developed since a combination of these modalities is critical to the affective component of the neurophysiological response evoked in taction. This next generation of sensors will include NEMS arrays and hybrid bio-NEMS systems. They will be integrated into a robotic finger with articulation controlled by neural network information processing that will allow artificial exploration of a surface to be achieved in ways that mimic human haptic behaviour and affective response. The impact of the project will include alleviating the effects of human touch and vision disabilities, improving the quality of life, security printing, brand protection, smart packaging, space exploration and also the evaluation of products such as textiles and skin creams using the instrumented robotic finger. The consortium includes industrial participants who will undertake specific technical exploitation activities in order to maximise the commercial impact of the research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'BotsAndUS - First Assistant Robot For Retail And Hospitality' (BotsAndUS).

assistant: **Concept**

The retail and hospitality sectors have been facing an international increase both in terms of demand and sophistication. However, they are facing a series of issues. For instance, online is threatening retailers, traditional hotels and event attendance, which offer the advantage of convenience, advocacy and smart, real time insights/data. Also, customers have become immune to marketing across all channels. In this context, it is crucial for the companies from these sectors to offer memorable, fund and useful experiences, which is the key to encourage and multiply visits and sales. BotsAndUS intend to take advantage of this context by offering companies that rely on face to face customer interaction a state-of-the-art robot. It is capable to interact with people of various genders and ages, to autonomously approach and engage in conversation, as well as react to emotions, all to offer outstanding customer service. The market size for retail robots will reach 10 billion euros in 2025, the annual reduction in the cost of manufacturing robots able to interact with humans will drop by 26%, whereas there will be 3o times more interactions per day between humans and robots. BotsAndUs aim is to develop a consumer robot, able to autonomously approach and engage in conversation, react to emotions. Our company puts the user at the centre of Human-Robot-Interaction and develops an innovative technology by combining social sciences, human-centred design and cutting-edge engineering. Bo is the first robot that combines various technologies from the ICT sector to obtain a “social robot”, which will be able to optimally interact with customers by engaging in conversations and adapt to various working environments and feedback from people. To ensure successful commercialization, in Pha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metabolism and CLinical Effects of Psychotropic Drugs - From molecular genetics to patient care', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To continue molecular genetic studies on genes encoding the most important enzymes involved in the disposition of psychotropic drugs; to study these enzymes from in vitro to in vivo in different genotype groups of different nationalities. To study relationship between genotype, drug plasma concentration and therapeutic as wells as side-effects during treatment of mental disorders. To investigate the molecular background to adverse drug reactions and drug-drug interactions.1.The molecular genetic basis for variation in the activity of the four major drug metabolizing cytochrome P450(CYP) enzymes CYP2D6, CYP2Cl9, CYP1A2 and CYP3A4 will be explored. DNA based genotyping techniques will be developed as tools to predict the metabolic capacity in large populations and in clinical studies in patients. Different variant alleles will be characterized in expression systems. Probe drugs for the individual CYPs will be developed and evaluated in male and female subjects from different ethnic populations.2. The contribution of different CYPs for the metabolism of mianserin and clozapine will be studied in human liver tissue in vitro. The possible relationship between aberrant metabolic capacity and the risk to develop agranulocytosis during treatment with mianserin and clozapine will be evaluated. Patients who have developed this adverse effect will be identified and tested for metabolic capacity using probe drugs (caffeine for CYP1A2) or genotyping (for CYP2D6). 3. The disposition of nortriptyline and fluvoxamine will be studied in healthy volunteers with different drug metabolic phenotypes and genotypes. This will elucidate the contribution of the phenotype as assessed by probe drugs or the genotype (CYP2D6) on disposition and pharmacological effects of the drug. Using this approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Low-dimensional quantum magnets for thermal management'.

assistant: **Concept**

Thermal management in innovative technology is a major problem to be solved, especially in novel electronic devices, such as further miniaturized microchips, hard disks and interfaces between biological structures (e.g. nerve cells) and semiconductor microstructures. In this Initial Training Network (ITN) we will train young researchers through an experimental/technological and theoretical approach to the application of a new highly efficient magnetic mode of thermal conduction for thermal management. This magnetic heat transport was discovered by members of this consortium and occurs in novel quasi-one dimensional insulating oxides. The crucial point of this project is that around room temperature the magnetic heat conductivity (of the order 100 W/Km) is as efficient as metallic heat conduction. Moreover, compared to conventional materials with high thermal conductivity, these novel compounds offer essential advantages: a) They are electrically insulating, b) heat is conducted primarily along one direction and c) heat is carried by localized spins which could allow for tunable heat conductivity at room temperature by manipulation of the spins with magnetic fields or light. Our scientific goal of exploiting this novel mode of heat transport for thermal management will be the basis for the research training in this ITN, which consists of 7 academic and 2 level-1 industrial partners. In order to tackle this scientific challenge in an multidisciplinary approach (physics, chemistry, materials science, computational science, electronic media), the fellows in our ITN will be trained on cutting edge experimental and theoretical techniques. In addition to training-through-research, the fellows will receive individual and collective training measures covering both scientific and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Competition in drug markets, entry of new products and doctor's prescritions' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Andrea Coscelli-TMR Research Proposal (Abstract) Research Objectives and Content Within the EEC, different countries have chosen different health care policies. These policies largely differ in the extent to which doctors, hospitals, and pharmaceutical companies are regulated. The economic literature has recently started addressing some of the issues determining competition in drug markets, building on the results made available by the medical literature and other social sciences. My research project is composed of different studies, each addressing a particular aspect of competition within therapeutic drug markets. I plan to study the demand for pharmaceutical products by doctors and patients by analyzing competition within molecule sub-markets and across molecules. I use data obtained from the Istituto Superiore di Sanita', which allow me both to (i) control for individual heterogeneity and (ii) investigate the economic decisions at the level at which they are formulated. By using the same detailed dataset, I plan to focus on the entry of new chemical entities (NCE) in therapeutic drug markets. The main question from a policy standpoint, is to analyze how new products gain a foothold among formularies. I answer this question by modeling how doctors choose drug therapies. The model is economic, and incorporates incentives for learning and experimentation. Ultimately, the study will provide estimates of a structural model of learning and experimentation within an agency relationship. Moreover, I want to analyze how institutional differences influence competition. I plan to analyze demand in the German market. I want to investigate issues of substitutability in prescriptions of generic and trade-name drugs in Germany over the last five to ten years. I want to estimate wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TELESURGICAL STAFFS' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The central aim of TESUS 1 is a federated European university hospital network for on-line telematics transmission of key-hole surgery imaging. This novel video-based technique minimises discomfort in convalescence and provides a precise close-up on operations for medical students. Regular weekly discussion and transmission for teaching of specific topics based on live surgical procedures will encourage international standardisation of practice. The project will help to optimise healthcare and to reduce costs and have applications in other sectors dependent on high-quality video.Laparoscopic surgery (surgery by minimal access, internal view by video camera and miniaturised instruments) is a new surgical technique which offers major benefits for the patient (reduction of postoperative pain and inhospital stay). Video imaging is intrinsic to the technique. Teaching and training are thus facilitated, as  the student sees what the surgeon is seeing during procedure ".The aim of the TESUS 1 project is to federate European University Hospitals (Belgium, Germany, France, Switzerland) in a network for on-line transmissions of surgical procedure imaging and counsel in day-to-day practise. European staffs organised every week on specific surgical topics and regular transmission, for teaching purposes, of live surgical procedures will allow for an approach to standardisation of practice accross the continent.Video data input into a surgical data base for teaching and training is also a goal of the project, as it will permit edition of " golden " standards in the speciality, reached by consensus.The specific creation of work methods and tools adapted for handling of surgical video information will be an important step in global European approach to health policies in the specialise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modulation of oligodendrocyte precursor cells differentiation fate during CNS remyelination' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The aim of this project is to identify the microenviromental factors and their downstream cellular effectors determining the fate of adult CNS precursor cells which could be modulated in order to control remyelination process. Remyelination is the best example of regenerative processes in adult CNS, in which new myelin sheaths are restored to axons that have been demyelinated as a result of oligodendrocyte death. However, the efficiency of remyelination decreases with age and in multiple sclerosis, a disease that can afflict a patient for several decades, there is a progressive decline in remyelination. The consequence of remyelination failure is progressive loss of the chronically demyelinated axons. Therefore, there is an urgent need to understand the cellular and molecular mechanisms involved in remyelination. New oligodendrocytes are derived from proliferating oligodendrocyte precursor cells (OPCs). However, we have demonstrated, in the lineage fate mapping study, that this name does not fully reflect their differentiation potential; under appropriate conditions they can also give rise to astrocytes and Schwann cells. We demonstrated that Schwann cells, derived form OPCs, occupied almost exclusively the tissue around blood vessels in astrocyte-deficient areas. Therefore the hypothesis postulating the occurrence of specific niches creating microenvironment that regulate or determine the alternative fate of precursor cells during remyelination arises. Our vascular-niche hypothesis, which will be investigated, predicts a causative role of BMP pathway in prompting OPCs to differentiation into Schwann cells or in blocking them in the proliferation phase.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Efficient low volume high variant robotized painting' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This project will realise an ultra flexible robotized spray painting solution for small lot sizes under low total volumes per year. The technical solution will be to integrate off-line CAD and sensing data with on-line robotic control. The consortium consists of 4 industrial end-user, 1 industrial technology provider, 2 research institutes and 1 private research organisation. The approach will be focused on industrial requirements and finally large scale basic building blocks, a first prototype implementation and finally large scale implementations. An industrial supporter group will also be setup to further integrate other interested companies, especially SMEs. Exploitation will be based on a new product range for this kind of application. Economic benefits of more than 121MEuro are expected within 3 years after finishing the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Vectors to Accessible Critical Raw Material Resources in Sedimentary Basins' (VECTOR), addressing dissemination and exploitation.

assistant: **Impact**

The EU imports 80% of its industrial raw materials making European supply chains highly vulnerable to disruption and threatening the EU's ability to manufacture raw material-intensive technologies, such as electric cars, wind turbines, and ICT hardware, that are essential to the green and digital transformations. Europe possesses significant mineral potential but development is limited by the lack of sustainable, low-impact exploration methods and by social opposition to mineral projects. With VECTOR we will generate new knowledge to overcome these technical and social barriers, unlocking Europe's raw material potential and improving the resilience of EU raw materials supply chains. Overcoming issues will require major changes of the business models in the extractives industry and to integrate a more human-centred approach. The VECTOR project is based on the premise that a prerequisite to any sustainable human activity is to minimize the environmental and social costs and include all the stakeholders in the decision making processes around this. VECTOR's overall objective is to deliver evidence-based and accessible knowledge that integrates the scientific and social pathways to successful mineral exploration and mining. The first pillar of our approach is a geological prospectivity toolkit based on an entirely new workflow using machine learning-based integration of less invasive geological, geochemical and geophysical measurements. The workflow will be validated in three European sedimentary basins and will be transferable worldwide. The second pillar is a social acceptance procedure that identifies, for the first time, the values that the European public invokes when deciding about mineral development. This will result in a Social Acceptance index and a new body of kn