RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cellular and animal models of Alzheimer's disease molecular pathology' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives:To develop cell culture and transgenic model for Alzheimer's disease (AD) synaptic loss, neurodegeneration and pathophysiology, to study the mechanism, to analyze the functional consequences, to evaluate strategies and model compounds aimed to prevent and cure and treat AD neurodegeneration and thus to provide industries assay systems for the development of new drugs relevant for the treatment of AD.Brief description: The pathophysiology of AD involves severe synaptic dysfunction, neuronal degeneration and cell death. Our rationale is, understanding the role of neuronal degeneration and death in AD disease progression depends on elucidation of the underlying regulatory mechanisms. This makes the availability of cell culture and animal models an absolute necessity that allow an indepth study of these molecular mechanisms. Our cellular and transgenic approach offers unique advantages by combining the unsurpassed advantages of in vitro systems with the complementing living model. The present programme is geared towards a better understanding of the pathophysiological process which is key to the discovery of new treatment principles. The programme goal is to establish both in vitro (cellular) and in vivo models of the pathopysiology of AD and thus to provide assay systems for the discovery of new drugs relevant for the treatment of AD. The specific aims are to generate cell culture models to elucidate the molecular mechanism of AD chronicity which depends on the deposition of Aß amyloid by coexpression of the Alzheimer amyloid precursor protein (APP) and clinical mutants therof with the other AD genes presenilin 1 (PSI), presenilin 2 (PS2) and different alleles of the ApoE gene, exposing these cells to Aß amyloid, to establish relation of Aß deposition to cell dy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Metastability of polymer systems by high-speed calorimetry'.

assistant: **Innovation**

A Marie Curie Industry Host Fellowship at DSM Research: Metastability of Polymer Systems by High-Speed Calorimetry Recently, at DSM Research, we successfully developed a new mode of measurement: High Performance DSC (HPer DSC), which represents a major step forward in high-speed calorimetry, as compared to standard DSC. HPer DSC will drastically improve researchers' ability to study the kinetics and metastability of systems. Controlled and constant scan rates up till 500°C/min and combinations thereof both in cooling and in heating are possible. Low, milligram-to-microgram scale sample masses are utilized. HPer DSC even proves heats of transition, heat capacities, temperature dependent crystallinities etc. at the extreme rates applied. Systems to be studied are linear PE's, homogeneous ethylene copolymers and PBT.The Fellow will study crystallization (mimicking realistic conditions, as during fast-cooling processes);subsequent melting;and reorganization phenomena during heating like cold crystallization, recrystallization etc., which obscure the interpretation of melting. Thus, the connection between crystallization and melting will be (re) established. In addition, for PBT, attention will be paid to the seldom-studied rigid amorphous traction. Other interesting topics will be explored: study of minute amounts of material as present in micro-thin (multi) layers, coatings and fractions; confined crystallization; pharmaceuticals will be looked at, etc. Real-time X-ray (WAXD and SAXS), solid-state NMR, AFM and TMDSC will be applied for interpreting of the results obtained. We offer outstanding and state-of-the-art tools for such characterization. Besides contacts with researchers of various institutes, the Fellow will have cooperation with processing and properties special
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Human Longevity: Why older individuals in poorer nations outlive those in wealthier nations' (LONGEVOUS).

assistant: **Concept**

Individuals in poorer nations generally live shorter lives than their counterparts in wealthier nations. Paradoxically, as people age, an intriguing reversal of this pattern emerges, with older individuals in certain low- and middle-income countries (LMICs) outliving those in high-income countries (HICs). Why do older people in LMICs outlive those in HICs? Why does the later-life survival advantage only occur for some LMICs? Answering these pressing questions is critical for addressing the current and future impact of aging societies and for advancing theories of the mortality transition that do not yet consider the diversity of aging experiences worldwide.LONGEVOUS has three ambitious goals and bold theoretical thrusts: (A) to assess the theoretical framework that explains the paradoxical later-life survival advantage in LMICs, (B) to assess the empirical mechanism behind low mortality at older ages in LMICs, and (C) to investigate whether this unexpected mortality paradox also emerges in terms of health outcomes. Project A tests the theory that adverse conditions over the life course create a group of robust individuals in later life. Project B develops a novel method for estimating mortality at older ages in certain LMICs, where the poor quality of age data remains unresolved and prevents us from testing mortality theories. Project C adds the health component to better understand country disparities in mortality at older ages. LONGEVOUS not only opens new perspectives for longevity research but also represents an unprecedented effort to conduct the most comprehensive study to date of the factors that shape mortality at older ages in LMICs.LONGEVOUS will use a combination of several demographic and statistical methods, and multiple data sources, including censuses, re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploring Visual Processes with Two-Photon Ophthalmoscopy' in the context of a Horizon 2020 call.

assistant: **Objectives**

In vivo methods to objectively assess retinal physiology are rare among existing imaging techniques. To accelerate the diagnosis of progressive outer retinal disease and the development of treatment before vision is seriously impaired, there is a need for such methods that can quantify visual cycle kinetics in the living eye.Two-photon ophthalmoscopy shows potential to provide new information in this regard paired with microscopic resolution of retinal morphology. The technique can noninvasively track the visual cycle via the transient fluorophore all-trans-retinol in rods and cones separately. In this proposal, we aim to establish two-photon ophthalmoscopy as a method to assess outer retina function and to explore its prospect towards clinical application. An adaptive optics scanning laser ophthalmoscope optimized for safe two-photon imaging in the human eye will be developed. With this instrument, we will quantify the visual cycle in rods versus cones in response to stimulation in healthy human subjects. Particularly the cone visual cycle is not yet fully understood and requires further study. Further, the visual experience of subjects exposed to two-photon ophthalmoscopy will be investigated. The technique uses a pulsed laser as imaging source aimed to evoke nonlinear processes in the retina that can potentially be perceived by the subjects. A detailed understanding of these pathways will provide greater insight into the first steps of vision and help to design suitable stimulus paradigms to test visual cycle function.Successful implementation of two-photon ophthalmoscopy in the human eye promises to deepen our knowledge of normal and abnormal visual cycle function and further our understanding of retinal biochemistry in health and disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genes controlling neuronal specification and differentiation' in the context of a Fifth Framework call.

assistant: **Objectives**

The generation of different neuronal phenotypes during development is a prerequisite for the function of the nervous system. The present proposal is focused on the role of major transcriptional control genes that are involved invertebrate neuron specification and differentiation. We aim to understand how their expression is controlled and how they exert their function. The functional analysis will include the identification of their target genes and the characterisation of the genetic and cellular context required for their function. A further aim of the project is to begin to understand the molecular link between neuron generation and withdrawal from the cell cycle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular interactions of cellulases: active sites, domains and substrates' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

This project is aimed at a better understanding of the structure of cellulases and cellulosomes, the spatial relationship and interactions among the individual domains of cellulolytic systems, their multi-subunit interactions and the details of the molecular forces which govern substrate binding and catalysis. Techniques of crystallographic structure determination, molecular biology, rational design of inhibitors and substrate analogues, light, neutron and x-ray scattering, thermodynamic and kinetic studies, and molecular modeling together with electron microscopy of the enzymes and cellulosomes in interaction with crystalline cellulose will be brought together. Substantial development will be undertaken of the use of synchrotron radiation, cryocrystallographic techniques and cryo-electron microscopy. The research results will be integrated to lay the foundations for a methodology for rational protein engineering for the production of tailor-made enzymes or multi-enzyme complexes with improved or novel catalytic activities. The controlled hydrolysis of selected regions of cellulosic fibres without adverse effects on the mechanical properties of the fibres is one of the parameters of critical interest. The project will involve three-dimensional structure determination, improvement of techniques including applications of synchrotron radiation and the development of biomolecules with desired functions thus conforming to all three aspects of the Biotechnology Work Programme - Area 6.1. The project is highly innovative and will push the state-of-the-art well forward especially with respect to the structures of oligosaccharide complexes and the component modules of the cellulosomes, the 3-D determination of multi-subunit complexes alone or in interaction with their substrates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Decoding local crosstalk in tumor formation', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Communication between different cell types is essential for many biological processes, both in homeostasis and in disease. In tumor initiation, growth and metastasis, cancer cells send and receive chemical and physical cues from their microenvironment. Those cues determine how disease progresses and influence proliferation and invasiveness of malignant cells. Understanding the crosstalk between cancer cells and their immediate environment is crucial for the advance of novel cancer therapies. Thanks to the development of single-cell technologies, we can now sample the complexity and the many functions of the tumor microenvironment. While immune cells are at the forefront of these studies, the mesenchymal fibroblast component is also a highly pertinent and significant player. In this proposal, I will focus on proximal communication between cancer cells and mesenchymal fibroblasts. Using intestinal cancer as a model, I will apply a multimodal approach to investigate the consequences of tissue crosstalk in the early stages of epithelial transformation and the activation of cancer-associated fibroblasts (CAFs). First, I will use tumoral organoid-naive fibroblast co-cultures to study the crosstalk between epithelium and mesenchymal fibroblasts in vitro, and its effect on fibroblasts gene expression pattern (objective 1). Secondly, I will interrogate the response of mesenchymal fibroblasts to epithelial transformation in vivo at single cell depth. I will identify new fibroblasts subpopulations (CAFs), study their origin and transcription factors involved in their activation (objective 2). Finally, I will study the tissue re-organization induced by crypt hyperproliferation using high-resolution confocal imaging and in situ hybridization, to spatially contextualize any changes i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NExt-generation MOdels for advanced battery electronics' to be submitted under Horizon Europe.

assistant: **Abstract**

NEMO project aims at advancing the state of the art of battery management systems (BMS) by engaging advanced physics-based and data-driven battery models and state estimation techniques. Towards achieving this goal, the consortium tends to provide efficient software and hardware to handle, host, process, and execute these approaches within high-end local processors and cloud computing.NEMO benefits from a wide range of sensor information acquired at high frequencies in addition to dedicated electrochemical impedance spectroscopy (EIS) sensors which allow for the identification of ongoing electrochemical reactions inside each individual battery cell. Capable hardware for storing and processing such measurements will be provided by the tier1 members of this industry onboard the consortium.The availability of such diverse physical information on batteries onboard makes room for developing cutting-edge performance, lifetime, and safety battery models and state estimators within NEMO, and validating them on two different BMS configurations. Physics-based performance model parameters continuously get updated as the battery ages, so that performance and safety state indicators maintain the least possible error. The data-driven approaches exploit mathematical algorithms to be trained upon the large datasets made available from historical or laboratory-generated battery information. Combinations of coupled physics-based and data-driven approaches are also foreseen to be implemented within NEMO as another innovation of the project to propose next-generation BMS.Solutions offered by NEMO considerably extend battery life and make the battery system safer within long-term operation since every individual cell is monitored, controlled, and studied. NEMO’s ambitious solutions for stat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Competition policy and vertical foreclosure' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content In the last years a special attention has been devoted by competition policy to vertical integration and exclusive dealing as a way to create a market dominant position. My research project is directed to identify a number of robust conclusions on the possibility and desirability (both social and private) of market foreclosure. In particular I conjecture that the following can be proved: when consumers prefer to concentrate their purchases with a single supplier a vertical agreement that broaden the product line is likely to create a dominant market position and have anticompetitive effects. The effect on consumers' welfare, however, may not be negative because the retailer's monopoly power is offset by a larger variety of products. I'm also interested in providing a general framework to analyze the effects of vertical agreements unifying the literature on mergers and exclusive contracts and providing general conditions for a merger outcome to be replicated through contractual relations. Training Content (objective, benefit and expected impact) I expect an essential progress of my thesis, being the . University of Toulouse one of the leading centers where research on industrial organization and especially on vertical integration is developed. Links with industry / industrial relevance (22) My research project has important links- with the european competition policy and especially with the activity of the European Commission in regulating mergers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Accelerating and upscaling transformational adaptation in Europe: demonstration of water-related innovation packages' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Climate change impacts are here and now. The impacts on people, prosperity and planet are already pervasive but unevenly distributed, as stated in the new EU Blueprint strategy (European Commission-EC, 2019). To reduce climate-related risks, the EC and the IPCC agree that transformational adaptation is essential. The TranformAr project aims to develop and demonstrate products and services to launch and accelerate large-scale and disruptive adaptive process for transformational adaptation in vulnerable regions and communities across Europe. The 6 TransformAr lighthouse demonstrators face a common challenge: water-related risks and impacts of climate change. Based on existing successful initiatives, the project will develop, test and demonstrate solutions and pathways, integrated in Innovation Packages, in 6 territories.Transformational pathways, including an integrated risk assessment approach are co-developed by means of 9 Transformational Adaptive Blocks. A set of 22 tested actionable adaptive solutions are tested and demonstrated, ranging from nature-based solutions, innovative technologies, financing, insurance and governance models, awareness and behavioral change solutions.The project team, led by the University of Antwerp, gathers 22 partners from 11 countries and a well-balanced mix of sectoral and adaptation experts (5 RTOs and 1 SME), paired with 6 territories (4 local authorities and 2 charities), 8 additional solutions providers and 1 EU water-related NPO specialized that will support to structure a European Community of practice.Massive resilience increase and acceleration of transformation adaptation will be fostered by clustering various investors, testing bankable solutions, and defining viable (non-)commercial exploitation strategy for the TransformAr so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Food shortages, hunger and death in 11th to 13th century Catalonia: an alternative model of analysis for short-term crises'.

assistant: **Innovation**

The research project that we are proposing aims to study the food crises (bad years, food shortages, dearths and famines) and the mortality crises which periodically afflicted Catalan medieval society between the early XIth century and the late XIIIth century. We will attempt to confirm, refute, redefine and perfect the historiographic models which have been constructed to explain their causes, mechanisms and interrelations. Using Catalonia as a laboratory of analysis and interpretation of the short term crises, in the words of E. Labrousse, and starting with a large variety of approaches , we propose: 1) to construct a chronology of the crises on a regional scale, determining as precisely as possible their geographic reach, periodicity, duration and relative severity also paying attention to the interrelations between food shortages and mortality crises and the relationship between regional crises and famines and epidemics which concomitantly effected the rest of Europe; 2) to consider the importance of distinct factors associated with food shortage (climatology, regional and international commerce in cereals, interconnection of urban markets, feudal wars and large international conflicts, accumulation of reserves or storage, speculation, etc.) in the unleashing, development and outcome of crises; 3) to gauge the consequences of famines and deaths on the economy, society and demography, both urban and rural; 4) to analyze the role of different social actors involved in the crises as well as the anticyclical policies implemented by the different spheres of power in order to insure the food supply of the kingdom and the cities; 5) to analyze the role played during the crises by charitable institutions, both ecclesiastic and private.