RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Electrochemically Driven Organocatalytic Transformations of Alcohols, Thiols and Disulfides' (ECOT).

assistant: **Concept**

The purpose of this research, set in the context of synthetic organic chemistry, is to develop unprecedented methods for electrochemically driven cleavage and subsequent functionalization of C–O and C–S bonds in alcohols, thiols and disulfides using organocatalysts based on phosphorus and sulfur. These radical methods will serve as keys to unlock the potential of the targeted compound classes as feedstocks for synthesis of functional organic compounds, e.g., pharmaceuticals, as well as for biomass valorization processes. Due to the complexity of the targeted transformations, the scarcity of available methods and the novelty of the outlined approach, the research will expand the synthetic toolbox, enable new retrosynthetic disconnections and late-stage (de)functionalization of, e.g., carbohydrates and peptides. Combined with the integrated mechanistic studies, the research will have a significant impact from a fundamental science perspective, as well as enable new synthetic applications. The project is divided into two main topics, each sized for one PhD student and one postdoc working together on the outlined work packages. The proposed research is supported by preliminary results that indicate its viability.


**Keywords:** electrosynthesis, organosulfur compounds, catalysis, C-centered radicals, cross-coupling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transitions in Rubble-pile Asteroid Chaotic Environment and granular Structures' (TRACES).

assistant: **Concept**

We are now living exciting times for asteroid exploration. The increasing availability of in-situ observation data, providing unprecedented level of detail, makes the study of asteroids an exciting and living frontier. Asteroids are rubble piles, i.e., gravitational aggregates of loosely consolidated material. However, no direct measurements of asteroids interior exist and little is known about the mechanisms governing their formation and evolution. Not only limited by a lack of data, the understanding of asteroids properties is challenged at afundamental level by their rubble-pile nature. This makes their dynamics subject to the laws of granular mechanics, one of the major unsolved problems in physics.TRACES enables a new paradigm for the characterization of granular systems in asteroid-related scenarios. The ambition is to demonstrate that the macroscopic behaviour of granular media in asteroid environment can be inferred from local properties of the grain. The methodology lays its foundation on a cutting-edge simulation tool, able to resolve the dynamics of grains to particle-scale precision, and a theoretical framework, able to decode the chaotic nature of particle-scale dynamics.TRACES hypothesis is validated through theoretical, numerical and experimental work. The ability of the methodology to characterize and identify transitions between dynamical regimes of granular media, is tested gradually, for increasing levels of realism, ranging between proof-of-concept, laboratory scenarios involving experiments in vacuum/low-g, and full-scale scenarios involving asteroid mission data.If successful, TRACES will enable the characterization of surface and internal properties of asteroids with limited observation data. This will play a crucial role to enable the next breakt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Atomic Force Microscopy for Molecular Structure Elucidation' under Horizon 2020.

assistant: **Concept**

Molecular structure elucidation is of great importance in synthetic chemistry, pharmacy, life sciences, energy and environmental sciences, and technology applications. To date structure elucidation by atomic force microscopy (AFM) has been demonstrated for a few, small and mainly planar molecules. In this project high-risk, high-impact scientific questions will be solved using structure elucidation with the AFM employing a novel tool and novel methodologies. A combined low-temperature scanning tunneling microscope/atomic force microscope (LT-STM/AFM) with high throughput and in situ electrospray deposition method will be developed. Chemical resolution will be achieved by novel measurement techniques, in particular the usage of different and novel tip functionalizations and combination with Kelvin probe force microscopy. Elements will be identified using substructure recognition provided by a database that will be erected and by refined theory and simulations.The developed tools and techniques will be applied to molecules of increasing fragility, complexity, size, and three-dimensionality. In particular samples that are challenging to characterize with conventional methods will be studied. Complex molecular mixtures will be investigated molecule-by-molecule taking advantage of the single-molecule sensitivity. The absolute stereochemistry of molecules will be determined, resolving molecules with multiple stereocenters. The operation of single molecular machines as nanocars and molecular gears will be investigated. Reactive intermediates generated with atomic manipulation will be characterized and their on-surface reactivity will be studied by AFM.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Investigating the Activity of transposon Derived Regulatory Sequences in the placenta' (InvADeRS) under Horizon 2020.

assistant: **Objectives**

Aberrant epigenetic regulation of placental function is implicated in several complications of pregnancy, such as preeclampsia, recurrent pregnancy loss and fetal growth restriction. Notably, the placenta has a unique epigenetic landscape, permissive for the activity of transposable element (TE) derived DNA sequences. TEs are often co-opted by the host genome as cis-regulatory elements, driving tissue- and species-specific gene expression programs. Indeed, TEs contribute many placental-specific enhancers in mouse trophoblast. However, the presence and role of a similar TE-derived regulatory network has not been explored in human trophoblast. As TEs are highly species-specific, such a network in humans would be expected to regulate species-specific placental characteristics, such as the deep interstitial invasion unique to great apes. TE-derived regulatory elements may therefore be important for placental homeostasis and be involved in diseases characterised by aberrant placental invasion. I propose to map TE-derived cis-regulatory sequences in human trophoblast ex vivo using their histone modification signatures. I will assess the regulatory potential of candidate TEs through transcriptomic analyses and motif analysis to reveal transcription factor binding sites, highlighting promising candidates of importance in the human placenta. I will then directly test the function of top TE candidates using CRISPR-Cas9 genome editing of the TEs in trophoblast in vitro, and measuring changes in expression of target genes. Finally, I will elucidate epigenetic and coding differences between complicated and normal control placentas at the functional regulatory TE loci I find, to identify correlations with disease. This project will provide a comprehensive analysis of an as-yet unexpl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Metabolic switch during mutant-PI3K-induced breast tumorigenesis and metastasis'.

assistant: **Concept**

Each year 1.1 million new cases of breast cancer occur among women worldwide and ~50% of the patients succumb to metastatic disease. Although the biology of metastasis has been intensively studied, the cellular and biochemical mechanisms orchestrating its steps remain largely elusive. In this proposal, I will study the metabolic rewiring accompanying breast tumorigenesis and metastasis. Switching of metabolism can be controlled by oncogenic pathways, such as the PI3K/AKT pathway, which is frequently activated in breast cancer through PIK3CA mutations. The host lab has created unique in vivo breast cancer models induced by mutant PIK3CA. Their preliminary data suggest that transformation and metastasis in these models is accompanied by metabolic changes, which present a unique window for therapeutic targeting. In this proposal, I intend to explore the role and molecular details of selected metabolic regulators induced by PI3K mutants during tumor cell migration, invasion and metastasis in vitro and in vivo. To this end, I will combine state-of-the-art gene expression and bioinformatic analysis, metabolomics and multiphoton intravital imaging . Furthermore, I will employ RNAi screens to identify global key metabolic regulators that are essential for breast cancer adaptation to metastatic sites. This study should lead to the identification of new biomarkers and/or targets for metastatic breast cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Political Economy of Distraction in Digitized Denmark' in the context of a Horizon 2020 call.

assistant: **Objectives**

Bridging anthropology, sociology, economics, psychology, political science, and data science, DISTRACT combines advanced data science tools and established social science analysis to explore a pressing challenge: the ever more alluring distractions of human attention in the age of smartphones and other digitized technologies.  DISTRACT departs from five linked hypotheses: 1) The attention is commonly (by scholars and laymen) seen as finite; ⇒ (2) As such, it is a scarce resource that is subject to competition and regulation; ⇒ 3) This is not new but it is acquiring unseen urgency in the current data economy; ⇒ 4) An interdisciplinary social data science approach allows for solid and novel investigation of this unmet scientific and societal need; and ⇒ 5) As the world’s most digitized country (and homogeneous population and state-of-the-art public databases), Denmark is an ideal site to study this political economy of distraction. Combining qualitative and quantitative data from four case studies, DISTRACT thus aims to trace and analyse the mental, social and material techniques by which attention is captured, retained and deflected in digitized Denmark. Analytically, we distinguish between three layers in which attention is managed and manipulated: a “mental”, “social” and “material” dimension. We also differentiate between three components of given attention/distraction sequence: the ‘”capturing”, “retention” and “deflection” phase. Empirically, case-studies shall be carried out of (a) national politics, (b) the tech business, (c) “off-the-grid” alternative communities, and (d) education and workplace environments. Data shall be collected, integrated and analysed via a combination of 1) qualitative methods, including ethnographic fieldwork and semi-structured interview
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The impact of genetic background in the activity of single neurons' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Behaviors are quantitative traits, influenced by natural genetic variants in many different genes. Ultimately, polymorphisms impact the activity of single neurons to modify behavior. However, studies to dissect neuronal circuits are performed in a single genetic background, without the genetic context where they evolved. In this action, I propose to study neuronal activity in a more natural genetic context, by manipulating the activity of single neurons and measuring the resulting impact on behavior in several genetic backgrounds. This will allow determining how robust are neural circuits to genetic perturbation and identifying polymorphisms that modulate neuronal activity at the single neuron resolution.To study the impact of genetic background in neuronal activity, I will use D.melanogaster, which offer versatile genetic tools to manipulate activity of single neurons, resources for rapid analysis of population genetics and robust behavioral assays. One conserved behavior that flies share with many other species is the freeze or flee response to threats. Many aspects of this behavior have been dissected in flies, including the role of descending neurons (DNs), which connect the brain to motor centers. In here, I will inhibit the activity of DNs previously shown to impact the freezing behavior in response to looming stilmuli. This will be performed in several genetic backgrounds, using a collection of inbreed lines with fully sequenced genomes. With this, I will identify polymorphisms that interact with the action of single DNs, trough genome wide association study (GWAS). The candidate genes from this analysis will be tested for their role in modulating the neuronal activity. NeuroContext will elucidate how genetic polymorphisms, present in natural populations, interac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Collective Regulation of Cell Decisions' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Developing systems show an unmatched complexity due to an entangled regulation across different levels of organization. Errors in this regulation often lead to tissue and organ malformations and disease. Accordingly, cell decisions like division, fate or motility are not only guided by local signals generated at the cell micro-environment, but also integrate cues propagated by collective properties at the tissue-level, such as tissue rigidity. How the cells macro-environment impacts cell decisions is still elusive, largely because we lack methods and concepts to identify and eventually control collective tissue properties. I will tackle this question by harnessing the physics of collective behaviours as design principles for synthetic in vivo developmental biology. We build on our discovery that embryonic tissue rigidity emerges via phase transitions, only when a simple cell parameter, cell connectivity, reaches a specific but generic value, the critical point. By identifying the responsible cell parameters and their critical points, we will build tools to tune those parameters, engineer for the first time, a set of tissue physical properties in vivo and explore their role in cell decisions. We will use the developing zebrafish as a model and: Quantitatively map cell parameters and the critical points at which tissue properties emerge; Control tissue properties by opto-genetically tuning the responsible cell parameters in relation to the critical points; Dissect mechanisms of collective regulation of cell polarity and fate decisions at single-cell resolution; Derive generic principles of multiple cell decision-making by comparing species operating near or far from critical points. Uncovering how collective properties impact cell decisions will reveal mechanisms of tissu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrocatalytic Production of liquid Organic hydrogen carrier and CHemicals from lignin' in the context of a Horizon Europe call.

assistant: **Objectives**

EPOCH proposes to develop a novel approach in linking green hydrogen production with the direct loading of liquid organic hydrogen carriers (LOHC) enabling a transformative logistic of green hydrogen distribution and storage. Lignin derivatives are used to be selectively oxidized. Compared to water electrolysis, EPOCH will advance the field by (1) using the nascent hydrogen at the cathode directly to load LOHCs allowing economic H2 storage and transport, and (2) converting at the anode waste lignin and its derivatives via selective oxidation. EPOCH is beyond the state-of-the-art solutions, as it does not form molecular H2 at the cathode nor generates oxygen at the anode. By modifying both cathodic and anodic reactions, EPOCH reduces the energy intensity. EPOCH will enable better cell performance and enhanced added-value device operations by (i) improving energy efficiency, (ii) allowing cost reductions, and (iii) intensifying the process. The EPOCH device will be designed for flexible integration with biorefineries and pulp & paper industries, to valorize their lignin waste streams, thus, linking these industrial sectors and H2 economy. EPOCH will allow the production of green H2 in areas where renewable energy production (in the energy mix) is higher. Therefore, EPOCH will offer a new path to effectively decrease the carbon footprint of energy-intensive industries.Development of the novel EPOCH electrocatalytic device requires (a) advanced components (electrocatalysts, electrodes, electrolytes and ionic liquid promoters, membranes) and (b) validation of the full module cell operation at laboratory scale. Thus, our project integrates multidisciplinary top-experts in areas such as electrocatalysis, lignin chemistry, and materials synthesis, with a large engineering compa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Upgrading Lower Silesia From Regional Innovation Strategy Towards Operating System'.

assistant: **Concept**

The importance of this proposal lies in catching the momentum for building new models of innovation flows from the science base to industry with the clear support of the regional parliament and the newly created policy documents. It is also the intention of self-government to achieve a profound future development on a long time horizon and foresee the pilot projects to satisfy future objectives. The consensus for Regional Innovation strategy has been already started, but the learning approach for all the regional actors (academics, business and administration) needs to be supported by a partner with outstanding experience in innovation systems and excellent links to other European networks and programmes. With the objective to build capability in Lower Silesia and ensure sustainable outcomes in all RIS-related fields and beyond, SEZ will accompany the project as a strategic partner making available its manifold bridging functions: linking regional actions to European initiatives, linking the different RIS actors from Lower Silesia to their respective partners (companies, RTO organisations, policy makers) in other regions, and integrating the different parts of an innovation process (long-term strategies, concrete action plans, RTD and TT, cluster- SME - and entrepreneur-support etc. The draft version of innovation polices requires evaluation and adjustments, therefore the RIS/RITS methodology will be supported by IMG Innovations-Management, who did the research for the Rheinland-Pfalz region. The mai n goal of UPRIS is to increase the competitiveness of regional SMEs. This aim requires speeding up Lower Silesia innovation mechanisms. Simultaneously, to creation of an action plan to be adjusted to the strategy document, the innovation activities need to be implemented. T