RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards understanding human consciousness: How internal brain states and environmental context shape our subjective experience' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Consciousness is subjective experience, the ‘what it is likeness’, for example to perceive a certain scene or to feel joy. In the last three decades tremendous progress has been made in identifying the neural correlates of consciousness at the level of whole brain regions. Meanwhile, outside the field of consciousness, rapid progress has been made in understanding neural, biochemical and psychological factors that have to be accounted for to further understand human consciousness. Most importantly, we know much more about the neurotransmitter systems underlying basic sensory processes in animals (e.g. neurobiology), the mechanisms responsible for fluctuations in wakefulness and arousal (e.g. anesthetics/neurobiology), and how perception is constructed by the brain’s predictions about regularities in the world (e.g. neuroscience/psychology). This research has, however, been performed in relative isolation from studies of human consciousness and clear opportunities to link these different fields remain largely unexplored. Here I will establish this crucial link by combining state-of-the-art neuroimaging techniques with pharmacological interventions and computational modelling in humans performing novel experimental tasks gauging subjective perceptual experience. My project has 3 main aims. I will first test the hypothesis that excitatory and inhibitory neurotransmitters play central, albeit different roles in recurrent neural processes, crucial for conscious experience. Second, I will test how subjective experience is shaped by spontaneous fluctuations in arousal and levels of physical activity. Third, I will test how conscious experience is modulated by the interplay between predictions and sensory input. This research promises to provide an integrative framework for und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High Pressure Electronically controlled gas injection for marine two-stroke diesel engines' in the context of a Seventh Framework call.

assistant: **Objectives**

The objective of HELIOS is to develop a marine low speed two-stroke gas Diesel engine research platform that is realistically sized for direct drive marine propulsion, and that has an emission footprint which compared to present Diesel engine technology is reduced as follows: CO2: 20-30%, NOx: 10-15%, SOx : 90-100%, PM: 60-70%. Since 99% of the world commercial fleet is powered by diesel engines, marine gas Diesel engine technology can greatly contribute to the greening of waterborne transportation. The potential of the HELIOS project is further enhanced by the possibility of retrofit of gas Diesel technology onto existing ships in service, since the needed modifications in components are limited and do not need removal or reinstallation of vessel’s engine. The research platform will be the basis for a new generation of high pressure gas injection engines operating on compressed natural gas (CNG) and/or liquefied natural gas (LNG), using Diesel type and partly pre-mixed combustion principles. The new generation of engines will be fully electronically controlled and have power ratings from 5.000 to 100.000 kW. The development of a marine gas Diesel engine concept being a realistic alternative to current technology places numerous challenges to the engine designer, ranging from development of reliable gas injection systems, layout of the combustion system including ignition control, engine monitoring, combustion chamber materials. Furthermore the project sets new standards for on board storage and distribution of LNG and CNG. HELIOS addresses all of the above aspects in an extensive R&D enterprise with duration of 3 years. HELIOS will drive forward new technologies, concepts for gas storage, high temperature materials and diagnostics methods, which will also strengthen Eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Restoration of tumor suppressor function by induction of translational read-through of premature termination codons - a strategy for improved cancer therapy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Tumor suppressor genes such as TP53, RB1, PTEN and APC are frequently inactivated in sporadic and inherited human tumors. A significant fraction of the mutations in these genes are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional proteins. We will identify and characterize novel molecules that can induce translational read-through of premature termination codons in nonsense mutant TP53 and expression of full length p53 protein. Hits will be tested for their effect on nonsense mutant RB1, PTEN and APC. We will also elucidate the molecular mechanism of action of the identified compounds by CETSA and other techniques. Moreover, we will test hit compounds on primary tumor cells from patients ex vivo, and generate mouse knock-in tumor models with nonsense mutant tumor suppressor genes for further characterization of hits. We will take the most promising hits through preclinical development towards clinical trials. Our aim is to develop novel and efficient targeted therapy for tumors with nonsense mutations in the TP53, RB1, PTEN and/or APC tumor suppressor genes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A novel combination treatment effective against all multidrug-resistant pathogens deemed as a critical priority by the WHO', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Antimicrobial resistance (AMR) due to multidrug-resistant Gram-negative bacteria are an increasingly serious healthcare threat, exacerbated by major economic issues underlying the development of new antibacterial drugs. The effectiveness of β-lactam antibiotics, the most important class of antibacterial agents, is impaired by the production of β-lactamase enzymes by drug-resistant bacteria. We are developing a combination of a well-known antibiotic (meropenem) and ANT3310, our proprietary, best-in-class serine-β-lactamase inhibitor, intended for the treatment of hospital-acquired infections caused by drug-resistant pathogens. Our treatment has been pre-clinically proven to be efficacious against all three pathogens deemed a critical priority by the World Health Organization (WHO).We will conduct three clinical trials and next out-license ANT3310 to a pharmaceutical partner. We expect market approval by 2029 and that ANT3310 will generate over €10bn in sales within 13 years.


**Keywords:** Infectious diseases,Carbapenem-Resistant Enterobacterales,Ancinetobacter baumannii,Pseudomonas aeruginosa,drug development,serine β-lactamase inhibitor,complicated urinary tract infections,nosocomial pneumonia,Antibiotics,Critical priority pathogens,Antimicrobial resistance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LAndslide Modelling and tools for vulnerability assessment Preparedness and REcovery management', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

LAMPRE proposes to execute innovative research and technological developments to increase GMES limited operational capacity to cope with triggered landslide events and their consequences, in Europe and elsewhere. LAMPRE will enhance landslide risk mitigation/preparedness efforts and post-event-landslide recovery and reconstruction activities, in highly vulnerable geographic and geologic regions. The project improves the ability to detect/map landslides, assess/forecast the impact of triggered landslide events on vulnerable elements, and model landscape changes caused by slope failures. These goals are achieved by (i) researching and developing new techniques and products to dynamically integrate satellite/airborne imagery, (ii) designing and using intelligent image processing techniques, (iii) modelling landslide-infrastructure interactions using advanced numerical modelling and ground based thematic information, and (iv) proposing standards for landslide mapping, susceptibility zonation and image processing. Products of LAMPRE, including geo-processing tools, landslide inventory/susceptibility maps, vulnerability/impact assessments, and standards and best practices, will be beneficial to Civil Protection authorities, environmental, agricultural and forestry agencies, organizations managing transportation networks, and Emergency Response and Land Monitoring GMES services. Results of LAMPRE will be relevant to the EU strategy for the prevention, preparedness and response to natural hazards, and the protection of people, property, infrastructures and the environment, to implement the EU Soil Thematic Strategy, and to the design of novel GMES landslide services based on images taken by the ESA Sentinel-2 satellites. To facilitate up take by users and cross boundary coopera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Impact of Integration Policies on Immigrant Outcomes: Cross-country Evidence from EU' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The proposed research will study the impact of different integration policies in European context. The labor market outcomes of the first generation immigrants, the educational outcomes of the second generation and intergenerational mobility will be explored. The cross country variation in labor market outcomes of first generation immigrants is determined by two factors: (1) selection of immigrants that determines the set of observed and unobserved characteristics that immigrants bring to a host country, (2) integration that determines how a given set of characteristics are valued in the host country. This study is going to identify the impact of integration independent of selection effects using a natural experiment. This natural experiment is the mass recruitment of Turkish workers by European countries during 1960s and 1970s that dispersed individuals with similar characteristics across various countries. The second part of the project will provide evidence on the educational outcomes of second generation immigrants from the same source country. Using an internationally comparable data set of 15-year-old students the study will focus on the immigrant students’ performance in mathematics, reading, science and problem-solving skills and provide evidence on the cross country variation in their outcomes. Using the data on educational attainment of parents intergenerational linkages will be explored to assess the extent of upward mobility in these countries. Thus, this study will be exploring integration with a multi generational perspective and highlighting differences in outcomes across host countries for individuals with similar backgrounds. These results will inform the discussions about the best practices for integration both at EU and national levels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Women Politicians in Africa: War of Symbols and the Struggle for Political Legitimacy' (WOMPOL-AFRICA) targeting Horizon 2020.

assistant: **Abstract**

In post-conflict periods in Africa, as a result of women’s limited access to means of meaning production, and various forms of censorship, patriarchal gender hierarchies are often restored and reinforced in part through scripts written primarily by men, and women are relegated to supporting actors, whose roles reflect masculinist notions of women’s proper 'place'. This impacts on women’s claim to political legitimacy since, in many African countries, political parties and leaders often justify their political authority morally by emphasizing their roles in liberating their nations from, for example, colonialism and dictators. Much of the current research on the topic of women in African politics tends to focus on increasing women’s political participation through quota systems and other formal mechanisms, or examining the relationship between women’s political influence and gender discrimination in society and social institutions. There is minimal focus on the experiences of women politicians and the precarious positions they often find themselves in their struggles for political legitimacy. Focusing on four African women politicians, my proposed study, WOMPOL-AFRICA, will fill this gap by examining how representations in various sites of meaning production, of the women’s roles and experiences, impact their claims to political legitimacy. The sites of meaning production to be examined include history books, news media, documentaries, biographical films, published biographies and recorded interviews. My main aim is to explore the insights that these sites of meaning production offer in relation to the struggle over meaning and women’s political legitimacy. The project intersects multiple disciplines, including history, postcolonial, political, cultural, gender and femin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Aerosols formation from Biogenic organic Carbon' to be submitted under Fourth Framework.

assistant: **Abstract**

To investigate the in situ" formation of organic aerosols from the oxidation of natural hydrocarbons in forest areas of Mediterranean A detailed study of the aerosol composition, and of the gas phase in condensable products and in photochemical  active species will be performed. The impact of organic aerosols on the local tropospheric chemistry and ozone  budget will be elucidated. This project will continue an active collaboration between european research groups  which was established in the frame of the EC project "FIELDVOC" dealing with the oxidation processes of  VOCs and particularly of isoprene in forested areas.  The project will involve two intensive field studies, coupled with a chemical modelling of the photooxidation  of biogenic VOC (mainly isoprene and monoterpenes). In the experimental part of the project two intensive  experiments are planned, they are based on the study of the chemical composition of organic aerosols and of  their evolution with aging of the air masses during their transport over the forest. They include "in situ"  measurements of gaseous species of photochemical interest (NMHC's, isoprene, terpenes, nitrogen oxides,  ozone, carbon monoxide, hydroxyl radicals), derived products of oxidation (ketones, aldehydes), aerosol mass  and size distributions, total organic carbon in aerosols, and speciation of this organic fraction (fatty acids,  alcohols, alkanes).  One major aim of the experimental part will be to determine the mass balance of organic aerosols and to  evaluate the dependence of the yield of aerosol production from the concentration of major organic precursors  (mainly alpha and beta pinene and isoprene) and from the concentration of nitrogen oxides and oxidants.  The interpretation of the data will be performed with a 1D transp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Prevention of Dementia using Mobile phone Applications' under Horizon 2020.

assistant: **Concept**

Background: The projected steep rise in global dementia prevalence will largely occur in low and middle-income countries (LMIC) and vulnerable populations in high-income countries (HIC). Up to 30% of all dementia is attributable to potentially modifiable risk factors. Mobile Health (mHealth) technology allows for scalable and widely implementable prevention programs using self-management for improvement of dementia risk factors. Objective: To make dementia prevention strategies accessible to populations in LMIC and vulnerable populations in HIC using mobile health technology.Methods: For this implementation project we will build upon the operational ‘Healthy Ageing Through Internet Counselling in the Elderly’ eHealth platform for self-management of risk factors for dementia and cardiovascular disease. Within vulnerable populations in HIC and in LMIC we will assess barriers and facilitators to adapt the existing eHealth platform to a culturally appropriate mHealth (smartphone) platform for self-management of dementia risk factors. We will use a blended care approach with participants receiving remote personalized support by a health coach to improve their lifestyle and actively reduce their risk of dementia. The adapted mHealth platform will be evaluated in a randomised implementation trial in 2400 older people at increased risk of dementia in China and a vulnerable population with low SES in UK. Main outcomes are implementation outcomes such as acceptability, feasibility and sustainability of our mHealth intervention, costs, and effectiveness on dementia risk reductionRelevance and impactPRODEMOS addresses the HCO-07 call by building on an existing eHealth intervention that will be adapted to an mHealth platform for dementia prevention, specifically tailored to vulnerab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electron transport and charging of si nanocrystals in sio_2 for single electron devices' (1998-2002) under Fifth Framework.

assistant: **Objectives**

This research project aims at conducting a thorough investigation of the electronic transport and the dynamics of charging/discharging phenomena occurring in MOS devices containing nanocrystals. The emphasis is on studying the electrical and optical properties of individual nanocrystals and acquire the necessary knowledge to improve the performance olscalable devices made with arrays of nanocrystals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'BIM-based holistic tools for Energy-driven Renovation of existing Residences'.

assistant: **Innovation**

Building Information Modelling is a critical element in the digitalization of the construction industry, which is necessary in order to unleash huge efficiency and productivity improvements.  BIMERR will design and develop a Renovation 4.0 toolkit which will comprise tools to support renovation stakeholders throughout the renovation process of existing buildings, from project conception to delivery. It comprises tools for the automated creation of enhanced building information models, a renovation decision support system to aid the designer in exploring available renovation options through an the accurate estimation of renovation impact on building performance as well as a process management tool that will optimize the design and on-site construction process toward optimal coordination and minimization of renovation time and cost.  At the heart of the BIMERR toolkit lies an interoperability framework, which will enforce semantic interoperability among BIMERR tools as well as with third-party legacy ICT tools to enable seamless BIM creation and information exchange among AEC stakeholders in an effort to enhance the rapid adoption of BIM in renovation of the existing EU building stock.  The BIMERR toolkit will be validated and demonstrated in 4 buildings in 3 European Member States. Two buildings will be used for pre-validation and implementation refinement and the refined BIMERR toolkit will support the actual renovation design and works in one residential building in Poland and a second one in Spain. The assessment and evaluation of the BIMERR toolkit after these real-life activities will feed material into two supporting horizontal project activities: i) dissemination and exploitation of project outcomes through the creation of best practice examples of BIMERR use that