RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Insulin resistance and Tauopathy : Insights from Drosophila models and human brain samples' in the context of a Horizon 2020 call.

assistant: **Objectives**

Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting about 20 million people worldwide. Although aging is considered to be the most important risk factor for Alzheimer's disease, growing evidence from epidemiological studies suggest that type-2 diabetes (T2DM) increases the risk factor of AD.While compelling evidence establishes a link between insulin resistance and amyloid burden, relationships to tau are far from clear. In a recent study, it was shown that dysregulation of brain insulin signaling in both AD and T2DM, correlates to hyperphosphorylation of tau, a key abnormal tau modification leading to neurofibrillary tangles. Recent reports indicated that AD was associated with brain insulin resistance with significant abnormalities in the expression of genes and activation of kinases that are regulated by insulin and insulin-like growth factor signaling. Although a connection has been suggested between AD and diabetes, the mechanisms that link insulin resistance to AD are still unknown.Insulin resistance also leads to the impairment of autophagic pathway needed for clearance of misfolded proteins in neurodegenerative disorders.The objective of this study is to utilize robust Drosophila models of tauopathy and diabetes to decipher the underlying mechanistic pathways connecting these two devastating diseases. Furthermore, this proposal aims to study the effect of autophagy towards clearance of misfolded proteins in the background of insulin resistance and subsequent treatment of disease models with insulin sensitizing/autophagy activating drugs to ameliorate disease phenotypes.The results from this study will be further validated in post mortem brain samples from healthy and diseased patients for future therapeutic studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Demonstration of Innovative Technologies towards a more Efficient and Sustainable Plastic Recycling' to be submitted under Horizon 2020.

assistant: **Abstract**

The main objective of POLYNSPIRE is to demonstrate a set of innovative, cost-effective and sustainable solutions, aiming at improving the energy and resource efficiency of post-consumer and post-industrial plastic recycling processes, targeting 100% waste streams containing at least 80% of plastic materials. To this end, three innovation pillars are addressed at TRL7: A) Chemical recycling assisted by microwaves and smart magnetic catalysts as a path to recover plastic monomers and valuable fillers (carbon or glass fibres), B) Advanced additivation and high energy irradiation to enhance recycled plastics quality and C) Valorisation of plastic waste as carbon source in steel industry. Innovations A and B can lead up to 34% of fossil fuel direct reduction for PA and 32% for PU. Approach C can lead to reductions of around 80% of fossil carbon sources in electric arc furnaces. The demonstration is completed by the performance of a rigorous holistic environmental and economic analysis (LCA and LCC) to ensure the industrial feasibility and the accomplishment of environmental restrictions. Efforts are dedicated to analyse non-technological barriers (legislative or standardization) that could hinder the proper innovations deployment.POLYNSPIRE also implies the development of a comprehensive business plan, gathering 7 business models and establishing a cross-linked relation between plastic, chemical and steel manufacturing industries. Its consortium, coordinated by CIRCE, ensures POLYNSPIRE success through the involvement of 4 RTOs, 1 university, 9 large companies, 6 SMEs and 2 multiplier associations. To that end, chemical companies (REPSOL QUIMICA, ARKEMA, NOVAMONT, NUREL and KOR), plastic compounders (BADA) and converters (MAIER), waste managers (IDS), technology developers (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Addressing multimorbidity in elderly atrial fibrillation patients through interdisciplinary, tailored, patient-centered care pathways' in the context of a Horizon 2020 call.

assistant: **Objectives**

Optimization of atrial fibrillation (AF) disease management is highly needed. The AF prevalence is 7.8% above the age of 65 years and it will further increase as the population ages and predisposing factors become more prevalent. Multimorbidity (93.5%) and polypharmacy (76.5%) are very common in these patients. The mean number of comorbidities is 5.0 in those ≥65 years old. There is a great need to optimize the management of AF patients - and not only the arrhythmia - to reduce the burden on patients, society, healthcare system and the economy. The aim of the EHRA-PATHS project is to create well founded, innovative systematic care pathways to tackle multimorbidity in elderly AF patients. We hypothesize that such a well-structured, interdisciplinary, and patient-tailored care program is feasible throughout all healthcare systems in Europe, and effective to optimize outcomes. There are 5 objectives:1. Further characterize multimorbidity, polypharmacy and sex differences in AF patients by means of clinical data registries.2. Perform a European needs assessment study to map current clinical practice and identify unmet needs concerning multimorbid AF patient management.3. Devise and implement new software-supported interdisciplinary, patient-centred care pathways to detect, manage, and follow-up on multimorbidity and polypharmacy in elderly AF patients with a focus on each patient’s unique profile.4. A two-part evaluation with an initial base mapping followed by a European cluster randomised controlled trial to evaluate the newly developed holistic care paths with predefined key performance indicators. A cost-utility analysis will be included.5. Disseminate the insights, care pathways and implementation strategy from this project to patients, physicians, hospitals, other hea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Eliminating Uncertainty in Coronary Artery Disease' under Horizon 2020.

assistant: **Concept**

Coronary artery disease (CAD) is a disease blocking blood flow to the heart. Identifying patients with limited blood flow is key in improving patient outcomes. 15O-water is the undisputed gold standard tracer for blood flow assessment, with more than 450 publications on the topic. However, the ultra-short half-life of 15O -water, the difficult image analysis and the lack of regulatory approved equipment have limited its use in clinical practice. This limits the transition from current practice (SPECT, with poor accuracy and low throughput) to PET. With MedTrace’s solution of hardware and analytical software, clinicians all over the world will get routine access to 15O-water PET, achieving unrivalled accuracy at a low-cost while increasing patients’ comfort.MedTrace’s addressable market potential draws on the installed base of current PET scanners (>500,000 worldwide in 2017), tapping into a multi-billion-euro opportunity for every 1% that starts using 15O-water. This market is even larger as we further build the evidence that 15O-water PET scans are safer and more cost-effective than current clinical practice. We are asking for grant funding to further mature our working prototype solution, validate it in a small cohort of patients in three different EU sites, and obtain CE approval to operate in Europe. We also ask for equity funding to scale in the US by conducting a phase III clinical trial for regulatory approval in the US. This will allow us to overcome all the remaining regulatory barriers and improve cardiac imaging worldwide.


**Keywords:** Radioactive Water, positron emission tomography, tracer, Cardiac PET, Quantitative Imaging,  Quantitative Blood Perfusion, Cardiac Perfusion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Optimised Real-time Yard and Network Management'.

assistant: **Innovation**

The Commission’s 2011 White Paper states that by 2050, rail should substantially expand its modal share over medium and long distances. This is consistent with the Policy goals of expanding rail capacity, both cited in the Horizon 2020 and Shift2Rail (S2R) calls. Considering the ambitious Horizon 2020 Key Performance Indicator (KPI) calling for a surge in the utilisation of capacity within a range 70-90%, yards, hubs and terminals play a key role in facilitating this step-change by contributing to a competitive, reliable and safe freight transport.  To meet the needs of S2R and Horizon 2020, OptiYard will design decision support tool for yard managers that will help them to optimise processes and manage their yards more efficiently. It will do this in real-time, with interaction with relevant network. The processes must be performed in real-time, to guarantee on-time delivery and operational efficiency, in particular, for single wagon transport. OptiYard addresses critical operational points of the transport chain (both rail marshalling yards or as transfer points to other modes) to improve capacity and reliability. OptiYard will facilitate real-time interaction between yard and relevant network IT systems that allow for software based planning and ultimately optimisation of single wagonload and blocktrain operational processes.Building on the current state of the art and practice, the ambition of OptiYard is to provide a fully functional software module where real-time yard management, interaction with the network and ad-hoc timetable planning will be simulated in real-time. The optimization module and algorithms will be proven for large and complex freight transport networks, and integrate well with IP5 activities towards automation, e.g. intelligent assets and automa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Accelerators Validating Antimatter physics' to be submitted under Horizon 2020.

assistant: **Abstract**

Antiprotons, stored and cooled at low energies in a storage ring or at rest in traps, are highly desirable for the investigation of basic questions on fundamental interactions, the static structure of antiprotonic atoms, CPT tests by high-resolution spectroscopy on antihydrogen, as well as gravity experiments. Antimatter experiments are at the cutting edge of science. They are, however, very difficult to realize and have been limited by the performance of the only existing facility in the world, the Antiproton Decelerator (AD) at CERN. The Extra Low Energy Antiproton ring (ELENA) will be a critical upgrade to this unique facility and commissioned from summer 2016. This will significantly enhance the beam quality and enable new experiments.To fully exploit the discovery potential of this facility and to pave the way for a vibrant long-term physics program with low energy antiprotons, advances are urgently required in numerical tools that can adequately model beam transport, life time and interaction, beam diagnostics tools and detectors that can fully characterize the beam’s properties, as well as in into advanced experimental techniques for improved precision and novel experiments that exploit the enhanced beam quality that ELENA will provide. AVA is a new European training network between universities, research centers and industry that will carry out an interdisciplinary and cross-sector antimatter research and training program for a cohort of 15 Fellows. It targets new scientific and technical developments and aims at boosting the career prospects of all trainees.


**Keywords:** Low energy antimatter physics, antiproton, positron, spectroscopy, ion trap, cooled beams, stored beams, CPT Theory, precision studies, fundamental symmetries, antihydrogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chemical sniffer device for multi-mode analysis of threat compounds' (ChemSniff).

assistant: **Concept**

ChemSniff will develop a multi-mode sniffer device for real-time detection of chemical compounds contained in CBRN-E substances. This will enable high throughput screening of soft targets such as vehicles, people and their personal effects.  The technology is based on a linear ion trap (LIT) mass spectrometer (MS) operating in a non-scanning mode. A non-scanning LIT allows selective ion monitoring of target threat molecules using optimal voltages for each ion mass without performing a full mass spectral scan. This result is higher sensitivity, simpler control electronics, smaller size, lower power consumption and cost. The limits of detection of LIT-MS instrument are in low parts per billion (ppb) with parts per trillion (ppt) levels achievable with suitable analyte enrichment provided by a pre-concentrator. Once the MS fingerprint of an unknown substance is measured, it can be compared online with a database of known substances enabling real-time rapid identification. In 2014 pre-prototype instrument was demonstrated in FP7 Project SNIFFLES. ChemSniff will develop a more compact MS-based than existing instruments on the market with extra capability for rapid scans of solid surfaces using suitable atmospheric ionisation inlet.  Methods for miniaturisation will be applied to all key components including the vacuum system, which is the most robust part. This will be done through improved designs based on results from numerical modelling, operational designs, novel low-cost 3D printing manufacturing, electronics simplification and vacuum system optimisation. The final instrument will allow reduced acquisition/operating costs, greater mobility, user friendliness and flexibility. Performance will be benchmarked against a state-of-the-art conventional MS system for in-field a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Standard test for alkali reactive rocks' in the context of a Fourth Framework call.

assistant: **Objectives**

Alkali Aggregate Reaction (AAR) is today reported in numerous countries around the world. Many researchers within the field of concrete technology are dealing with this topic. In the last years, the number of papers on AAR has increased very much as seen from e.g. the proceedings from the conferences 'Durability of Building Materials and Components' and 'International Conference of Alkali Aggregate Reaction'. The reaction mechanism is very complex and depends on the type of geological material. For example, in Denmark the reactive aggregate is low density porous flint, in United Kingdom chert, in Belgium porphyries rocks, in Sweden limestone's and mylonitic rock, in Norway different types of dense volcanic rocks, quartzite and other high density rocks; in other of the European countries there is no knowledge of the type of reactive aqgregate. In some of the European countries there are strong restrictions on aggregates due to AAR. These restrictions are based on national standard tests generally built on empirical knowledge of the national types of aggregates. In Denmark there are only restrictions on low density flint and the national tests will accept imported high density reactive aggregate without any problems even if the aggregate is reactive measured by other methods. Similar situations exists in other countries. There are, at the moment no CEN or ISO effort to solve the problems of testing for reactive alkali aggregate rocks. A RILEM group, in which several of the partners are participating, are working in the similar area, but in world scale. The RILEM procedure is, however, extremely slow and results can probably first be achieved on a 10 - 20 years basis. The coming European standard for concrete aggregates proposed by the committee CEN/TC154/SC the document '
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Researchers in the Knowledge Triangle' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Since 2006, members of EURAXESS Bulgaria have organised 12 European Researchers Nights (ERN), and have attracted several new consortium members with different profiles – universities, research institutes, NGOs, entrepreneurs. Based on past experience, the main goal of Researchers in the Knowledge Triangle (K-TRIO 4) project is to bring researchers closer to society, attract young people to STEM and boost citizens science. The project will contribute for increasing the number of researchers and innovators in Bulgaria by making the society, and young people, aware of excellent European achievements in research and innovation, and of the success of Centres of Excellence (CoE) and Centres of Competence and their contribution to the Intelligent Strategy for Smart Specialisation in Bulgaria and regional development. Aware of the need of changing stereotypes and nurturing a new culture in research and innovation, the consortium will make young people aware of the multiple career paths of researchers (incl. MSC fellows), best-practice examples of researchers achievements, and research infrastructure in Bulgaria. Special emphasis will be made on European policy and on funding for research and innovation provided by EU RTD programs and Structural Funds.With a large variety of pre-events, online activities and 2-days ERN events in many Bulgarian cities, the project will create greater understanding on how research and innovation contribute for well-being of people and sustainable development, and highlight the common European efforts for building Digital Single market, Factories of the Future, Smart Cities, and take full advantage of BIG Data and Cloud computing. With the involvement of all CoE UNITe partners, and their large network, in addition to EURAXESS Bulgaria, K-TRIO 4 wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The modeling of the composite behavior of households in developing countries'.

assistant: **Concept**

Because of the deficiency of market structures but also because of the living standards, many behavioral phenomena cannot be separated in many developing countries. The modeling of the composite behavior of households in developing countries implies complications both in the economic optimisation program and in the econometric specification. I study the theoretical properties of non standard and nonseparable models, the specification of technologies, and advanced estimation methods adapted to these models. Several models should be estimated: - allocation of time among daily activities - technology for the health and nutrition status - consumption choices - production decisions. The results expected are: - A clarification of the theoretical properties of composite behavior models.  - The estimation of interactions between the economic behavior and the human resources status, for the households of Rwanda. - The derivation of applied welfare analysis and development policy conclusions.