RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The first portable, low-cost, robotized scanner microscope that converts any smartphone into a high quality and intelligent tele-microscopy image diagnosis system' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Healthcare accounts for approximately 10% of global gross domestic product. While the average life expectancy increases and some diseases are disappearing, other diseases raise. Cost of healthcare is a major economical challenge leading to unequal distribution of health benefits, which starts with the access to medical diagnosis. This situation and the new industrial revolution creates an opportunity to transform and innovate in the healthcare domain. MicroSpot is the first portable, low-cost, robotized scanner microscope that converts any smartphone into a high quality and intelligent microscopic image diagnostic system. MicroSpot is connected to a cloud ecosystem, capable of real time streaming and remote control and an artificial intelligence assistant for image analysis.MicroSpot aims to replace the actual obsolete equipment and processes used in microscopic medical image diagnosis while revolutionizing current manufacturing methods. MicroSpot democratizes the access to clinical image diagnosis by creating a new generation of medical devices that reduces time, costs and distances bringing microscopic image diagnostics closer to the point of care.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Effect of nutrient intake on the expression of genetic variation in behavioural syndromes'.

assistant: **Concept**

Behavioural traits are often correlated among individuals, called ‘behavioural syndromes’ in the recent behavioural ecology literature. Behavioural syndromes are shaped by the joined effects of genetic environment factors that simultaneously affecting multiple behaviours. The relative importance of each component has not yet been studied, despite major evolutionary repercussions of alternative proximate underpinnings. In the proposed study, the incoming fellow will use southern field crickets, Gryllus bimaculatus, as a study organism to test whether the acquisition of resources is an important determinant in shaping the expression of genetic correlations across diet environments. Such gene-environment interactions affecting behavioural correlations have been predicted to exist in nature because the expression of behavioural syndromes is environment-dependent in many animal taxa. Given the effect of diet on individual behavioural variation and covariation, nutrients are expected to have a role of shaping behavioural syndromes. The fellow will thus manipulate diet (carbohydrate-high or protein-high) in a quantitative genetics design, and measure multiple behaviours repeatedly. By comparing the structure of genetic correlations across two diet treatments, the fellow can test the role of diet (environment factor) on shaping genetically underpinned behavioural syndromes in crickets. If the expression of genetic correlations is indeed diet-dependent, it implies that behavioural syndromes are evolutionarily ‘labile’. The proposed work thereby represents the first experimental test of the hypothesis that the genetic structure of behaviour imposes constraints on the evolution of behavioural traits. Consequently, this proposed research will highlight how evolutionary approach to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Acute oxygen sensing and oxygen tolerance in C. elegans' (2014-2020).

assistant: **Innovation**

Oxygen (O2) levels can vary enormously in the environment, which induces dramatic behavioral and physiological changes to resident animals. Adaptations to O2 variations can be either acute or sustained. How animals detect and respond to the changes of O2 availability remains elusive at the molecular level. In particular, what is the precise mechanism of acute O2 sensing, what are the primary sensor for acute hypoxia, and why do neurons of various species exhibit completely different sensitivity to hypoxic challenges? The research proposed here aims at addressing these intriguing but challenging questions in the model system nematode C. elegans, which offers unique advantages to systematically dissect O2 sensing at both genetic and neural circuit levels. C. elegans responds dramatically to acute O2 variations by altering its locomotory speed. We will make use of this robust behavioral response to O2 stimulation for high-throughput genetic screens, aiming to identify a collection of molecules critical for acute O2 sensing. These molecules will be subsequently characterized in the context of a well-described nervous system of C. elegans. Our findings will offer the opportunity to shed light on conserved principles of acute O2 sensing that are operating in the O2 sensing systems in humans such as carotid body. In addition to its robust responses to O2 variation, C. elegans exhibits remarkable tolerance to a complete lack of O2, anoxic exposure. My team will thoroughly investigate anoxia tolerance of C. elegans by performing a screen for anoxia-sensitive mutants that has previously been challenging. The discoveries will allow us to delineate the molecular underpinning of anoxia tolerance in C. elegans, and to inspire other researchers to develop better strategies to cope wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integated approach to the biological basis of age estimation in commercially important fish species' (IBACS) under Fifth Framework.

assistant: **Objectives**

Our objective is to develop a fuller understanding of the environmental influences on otolith growth, leading to a new protocol for estimating fish age. Focussing primarily in gadiform otoliths, we will use known-age material to develop artificial neural network models of age. Otolith growth models will be integrated with results from new laboratory and field investigations to improve the objective basis for interpreting seasonal and non-seasonal growth structures. We will work on hake and cod representing a large proportion of the European fisheries in value and volume. As such, this proposal will improve the confidence and reliability of the scientific data used to underpin management of sustainable fisheries.ObjectivesThis project is a co-operative venture to improve our understanding of the biological basis of age estimation for commercial fish species. Our objective is to integrate modelling, laboratory and field observations to provide an objective basis for interpreting the macrostructure of otoliths used for estimation of fish age. We will take a muIti-disciplinary approach, including mathematical modelling, geochemical analysis of oxygen isotope ratios, experimentation and collection of biological and environmental data, to develop generic models of otolith formation. We will establish a new age estimation protocol, an enable training through a web site accessible by fisheries laboratories and fishermen's organisations.Description of the workTo achieve a generic understanding of the formation of calcified tissues, we will progress from model development, through new field and laboratory investigations, to the production of a new protocol for age estimation supported by interactive training media. We will begin by developing models of otolith growth and shape. W
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Selective packaging of proteins for secretion via COPII vesicles' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Protein secretion is an essential cellular process that delivers many diverse proteins to the extracellular environment or cell surface. This process contributes to many aspects of cellular function, including nutrient uptake, cellular communication and tissue integrity. Secretion starts with secretory protein biogenesis and folding in the endoplasmic reticulum (ER) followed by their export from the ER and transport to the Golgi apparatus via COPII-coated vesicles, to finally reach their final destinations. These vesicles play a pivotal role in quality control of secretion by selectively packaging cargo proteins that are fully folded and transport competent. Defects in this process can lead to diseases such as cancer and neurodegenerative disorders. However, the molecular mechanisms governing selectivity in vesicular trafficking remain poorly understood.PACK-COP will reveal how a specific family of cargo receptors, Erv14/CNIH, drives the selectivity of secretion across a diverse range of clients. The molecular mechanism underlying this selectivity into nascent vesicles will be dissected using a combination of yeast and human model systems. In yeast, PACK-COP will use mutagenesis and specific cross-linking approaches to discover protein-protein interaction interfaces that drive multiple known cargo proteins into COPII vesicles. These insights will be directly applied to human cells to map the client landscape that uses CNIH1 for ER export, and test specific functional domains based on the yeast discoveries. The innovative combination of both models, coupled with cutting-edge techniques, will enable PACK-COP to map Erv14 specific amino acids required for the ER export of critical cell-surface proteins. This knowledge could enable screening for inhibitors that block these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Assessing climate response options: policy simulations - insights from using national and international models (ACROPOLIS)' (ACROPOLIS), addressing dissemination and exploitation.

assistant: **Impact**

Objectives and problems to be solved:ACROPOLIS aims at applying and comparing existing models to assess the impact of energy technologies and policy measures on GHG emissions and on sustainability in a global systems analysis perspective. The questions to be explored are to what extent technologies can facilitate the required emission reductions both in the short and long term and to what extent policies can foster the development of new technologies and their subsequent deployment. The framework of the Kyoto Protocol shows a clear need for policy makers and governments having access to analytic resources for an evaluation from technological, environmental and economic perspectives. The various options have to be considered and integrated on the national, regional and world level. This is done with a variety of models on basis of a comparison of scenario runs.Description of work:The work follows six distinct phases:1. Compatibilisation and homogenisation of initial conditions needed to define the baseline or the business as usual case for each of the used models.2. On this basis, the impact of a full internalisation of external costs in energy production and use is examined. It is considered, that an additional charge on energy products will reflect the environmental damages from climate change, the risks of accidents and the damages form other pollutants.3. The following phase illuminates the impact of a regulatory policy in the energy supply side by a renewable portfolio and tradable green certificates.4. The next task is to model and discuss the impact of a policy of increasing energy efficiency standards. Such standards could be the minimum required efficiency ratio for new appliances (e.g. refrigerators), new cars (litres per 100 km), new processes or new power pla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Towards a Reliable Model for Dark Matter Search Experiments'.

assistant: **Objectives**

There is ample evidence that our Milky Way is embedded in a halo of Dark Matter. While the sun is revolving around the galactic center, it moves through this halo resulting in a constant Dark Matter wind on earth. The revolution of the earth around the sun produces then an annual modulation of the intensity of this wind. Dark Matter detection experiments have produced contradicting results so far. While the DAMA/LIBRA experiment reports the measurement of an annual modulation consistent with a Dark Matter signal, other experiments have not seen an interaction so far. The SABRE experiment aims to shed light on this controversy by detecting the annual modulation in the same target material as DAMA but with improved the sensitivity and using twin detectors in the northern and southern hemispheres. SABRE is currently preparing for a proof of principle at the same underground laboratory in Italy where DAMA operates, and will upgrade afterwards to the full-scale experiment.This fellowship will enable me to drive the SABRE experiment through the proof-of-principle stage to the full-scale instrument. To fully understand the detector response to a dark matter signal or background radiation, end-to-end simulations are essential: I plan to include the interaction of the incoming particle/radiation with the detector, signal dispersion and collection including a full optical model, as well as the subsequent processing by the data acquisition electronics. Measurements with a high-purity crystal during the proof- of-principle phase will allow their intrinsic radiopurity to be fully characterized, which is a key input to the simulation. I will also measure the optical properties of the materials involved, another crucial part of the end-to-end simulation software. Using these results,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MicroRobotic toolkit to deliver spatiotemporally resolved physicochemical signals and control cell sociology' to be submitted under Horizon 2020.

assistant: **Abstract**

Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate and comprehensive models of cell sociology, we need to identify how several different components act together as a connected system and define high-order emergent programs that constitute layers of signals in time and space. The objective of this proposal is to engineer new microrobotic technologies that can be seamlessly integrated with high-throughput bioengineering platforms and produce physiologically relevant signals to establish an active dialogue with the members of the tissue community and drive the cell-network evolution. We propose to build cutting-edge robotic micromanipulation systems to perform automated operations on 3D biological samples with exceptional dexterity and high spatiotemporal resolution. Wirelessly powered micromachines will modulate local mechanochemical signaling within the tissues and move through fibrillar scaffolds. Multi-functional integrated platforms will simultaneously apply external and internal signals, and advanced imaging systems will visualise whole tissue activity at the cellular resolution. Our data will be used to establish computational models of tissue-level mechanical response to dynamical perturbations with particular focus on transmission of signals and feedback mechanisms. The ability to hack cellular communication links and interfere with the biological processes in 3D systems will lead to a better understanding of morphogenesi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biosensor based instrumentations to be used in vineyards and wineries for fast and sensitive detection of Botrytis cinerea ,grey rot, in grapes' in the context of a Seventh Framework call.

assistant: **Objectives**

Botrytis cinerea is a fungus that affects wine grapes and is responsible for the grey rot infection, which can strongly alter the quality of grapes and derived wine, causing: browning, destruction of flavour compounds, decrease of foaming properties, fermentation stopping. Grey rot is the largest infection of grapes in vineyards all over the world and is a major problem both for wine growers and wine producers, being very rapid and resistant to fungicides. The derived economic impact is disastrous, accounting for the loss of 15-40% of harvests, overcoming 15 billions of Euro per year (25% of the potential world wine production turnover). Quality control is usually done visually or through lab based analysis which need several minutes and are highly complex and expensive. The SAFEGRAPE aims to develop a simple and cheap instrument for the wine industry, able to provide a quantitative and reliable evaluation of the presence of grey rot infection in grapes in a very short time. The instrument is based on a biosensor system and on an innovative analysis method, that allows a precise and very fast analysis procedure, i.e. in less than one minute, which is compatible with the quality control procedures applied to grapes before wine-making (measure of total acidity, sugar content).  The main result expected from the project is the development of the biosensor system integrated in 2 instruments: 1. portable instrument for the measure in vineyard, to be used by winegrowers in the field or after grape-harvest; 2. on-line instrument for quality control in wine production sites, to be integrated in the quality controls commonly applied (sugar and total acidity content).  These instrumentations will allow to increase the wine quality and reduce the loss of harvest of about 10%, by a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Analysis at Infinity: Integral Equations, Limit Operators and Beyond'.

assistant: **Concept**

The main objective of this project is to investigate fundamental properties of singular integral operators and apply our findings to concrete problems in mathematical physics and engineering. Our approach is to combine newly developed limit operator methods with Riemann-Hilbert analysis. Our plan is divided into three parts. In the first part we develop the limit operator fundamentals. We use the existing limit operator theory and transfer the methods to integral operators. In the second part we combine limit operator theory with Riemann-Hilbert analysis to obtain fundamental properties of Toeplitz operators like boundedness and Fredholmness. We will also use this combination to find double-scaling limits of Toeplitz determinants, which are used, for instance, to understand spontaneous magnetisation in the 2D Ising model. In the third part we will apply our results to concrete integral equations, e.g. the double layer potential. Our ultimate goal will be to resolve a long-standing spectral radius problem. The project combines the expertise of the Applicant (limit operator theory) very well with the expertise of the Supervisor (Riemann-Hilbert analysis) and the Host's analysis group (integral equations, mathematical physics). By combining these fields in a novel approach, this project opens up new research possibilities and greatly contributes to European research excellence in analysis and its applications. The results will be published in high-level journals and presented at international seminars and conferences. A workshop on the proposed topics will be organised at the Host university and a blog will keep everyone updated on the progress. The scientific research is accompanied by teaching, supervising students and workshops on complementary skills. This ensures that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Photon integration in the circadian system: irradiance and temporal variations.' under Fifth Framework.

assistant: **Concept**

Circadian activity rhythms in mammals are synchronized by daily light cycles. The aim of the present study is to examine cellular and physiological mechanisms (gene expression, electro physiology, behaviour) involved in photon integration by the circadian system using animal models and human subjects.