RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pirsonia-Coscinodiscus as an emerging marine model system for microbial host-parasite interactions' (PhytoParasite).

assistant: **Concept**

Marine ecosystems are dependent on complex ecological networks. One such network is the ""microbial loop"" which defines global oceans by influencing carbon cycling through the fixation and release of carbon by microorganisms. Although carbon fixation is well understood, factors beyond predation that impact cell death and carbon release remain understudied . Microbial marine parasites can greatly impact carbon release by driving the collapse of massive algal blooms and impacting phytoplankton population sizes. However, our understanding of the mechanisms governing these host-parasite interactions are limited, largely due to a lack of tractable model systems. The PhytoParasite project will address this issue by developing an emerging host–parasite model system comprised of the bloom–forming diatom, Coscinodiscus radiatus, and the zoosporic parasite, Pirsonia diadema, with the goal of answering fundamental questions about the ecological implications, molecular mechanisms, and evolution of phytoplankton parasites. To this end, I will (1) investigate the ecological implications of these parasites by using live–cell fluorescence microscopy to understand the effects of environmental factors on infection dynamics, (2) identify genes involved in parasitism and host responses by performing single–cell RNA sequencing during infection progression, and (3) uncover the mechanisms underlying the parasitic interaction and its evolutionary history using functional experiments and comparative genomics. This work will reveal the ecological implications and genetic underpinning of this important interaction, help develop a framework for understanding the evolution of eukaryotic parasitism, and importantly provide a new model system for understanding microbial interactions in our rapidly c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of symmetries in string theory' in the context of a Fourth Framework call.

assistant: **Objectives**

String theories are to date the best candidate to unify all known force into one single model. It is believed that there is a single consistent theory with a huge symmetry, which is not completely known yet. The symmetry obtaining most interest at the moment is duality. An aspec of duality is that it relates physics at large and small scales. This means that one can learn about microscopic theories by studying string inspired cosmology, and vice versa.  Proposed is to study the effect of these symmetries by looking at the abovementioned contrary subjects, as to get a deeper insight into their physical meaning and their connection with the standard model.  The duration of the proposed project is estimated to be three years and will hopefully end in a PhD. degree.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Green Technologies for 5/6G Service-Based Architectures' (6Green).

assistant: **Innovation**

The 6Green project aims to conceive, design, and realize an innovative service-based and holistic ecosystem, able to extend “the communication infrastructure into a sustainable, interconnected, greener end-to-end intercompute system” and promote energy efficiency across the whole 5/6G value-chain.The ultimate objective is to enable and to foster 5/6G networks and vertical applications reducing their carbon footprint by a factor of 10 or more.To achieve this objective, the project will exploit and extend state-of-the-art cloud-native technologies and the B5G Service-Based Architecture with new cross-domain enablers to:1) boost the global ecosystem flexibility, scalability and sustainability, and 2) enable all the 5/6G stakeholders (from the ones acting at the infrastructure and network platform to vertical industries) reducing their carbon footprint by becoming integral parts of a win-win green-economy business, and meeting a Decarbonization Service Agreement.The 6Green intent-based cross-domain interactions among stakeholders will allow achieving a tight proportionality between the time-varying and geographically distributed mobile workload produced by vertical applications and network slices, and the energy/carbon footprint induced to the 5/6G network and computing infrastructure continuum. 6Green will provide stakeholders with flexible and green Artificial Intelligence mechanisms that will allow propagating the environment impact to any players acting on virtual domains, and triggering zero-touch operations according to customizable energy- and carbon-aware policies, allowing to optimally use renewable energy sources.The project will also deliver three future-proof use-case applications that will provide a diverse awareness of the green capabilities of the 6Green plat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Wavy N-doped Graphene Nanoribbons for Single Molecule Electronics' under Horizon 2020.

assistant: **Concept**

Graphene nanoribbons (GNRs) combine the advantages of pristine graphene with the semiconducting properties required for applications in organic electronics. The properties of GNRs are significantly dependent on their structural variables such as molecular length, width and edging structures.  However, it remains quite challenging to achieve atomically precise control over the structures of GNRs simultaneously, therefore new synthetic approaches are highly desirable. In this proposal (WavyRibbons; Wavy N-doped Graphene Nanoribbons for Single Molecule Electronics), a novel synthetic approach is proposed to afford GNRs with controllable length, wavy (hybrid armchair and zigzag) shape and N-doping.  The properties of these GNRs will be fully characterized. These structure defined GNRs bearing suitable ending groups also provide a unique platform to study the charge transport properties in single molecule junctions, which will shield new insights into this important but unexplored field. The appropriate working plan taking into account 1) background of the fellow; 2) experience of the host groups; 3) resources available will ensure the achievement of this proposal. And, the success of WavyRibbons will not also signify a real breakthrough in fundamental research but also benefit all the parties involved.


**Keywords:** graphene nanoribbon, charge transport, single molecule electronics, novel synthetic approaches, structure-property relationship
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Rodent models for oligogenic human diseases: infrastructure facilitating the progression from genetics to the gene containing the putative aetiological variant & to the functional validation of genes & pathways' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This proposal enhances infrastructure provision for the efficient exploitation of rodent models leading to the identification of genes and their biological validation. These genes and pathways are then potential targets for therapeutic intervention. The key areas for development are: Discovery of rat and mouse Snips and construction of mapping panel coupled with the development of very high throughput SNP genotyping technology based on mass spectrometry resulting in more efficient QTL mapping. Mouse cosmic panel and associated resource generation to facilitate QTL refinement mapping. Cross species and specialised tissue expression profiling to identify genes underlying Atlas and the pathways relevant to these traits. Comparative, QTL and Pathway gene maps to facilitate correlation with Atlas mapped in different species (Human, rat and mouse). Genotype driven recovery of an ENU allelic series in mouse to functionally validate genes of interest.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ROutine diagnostic tool for Urinary Tract INfections caused by Esbl and carbapenamase producing bacteria' in the context of a Seventh Framework call.

assistant: **Objectives**

Treatment of Urinary Tract Infections (UTI) is currently initiated empirically because conventional diagnosis takes 2-3 days from sample to results. Moreover, the pharmaceutical pipeline is almost dry. Therefore, the last decade has globally witnessed a huge explosion of antibiotic (AB) resistance in Gram Negative Bacteria (GNB), which has drastically reduced the available AB therapy choices for UTI. The WHO considers this one of the major public health threats. Rapid detection of bacterial species and their AB susceptibility provides the main option to curb this development and prolong the lifetime of currently available antibiotics.In ROUTINE, 3 SMEs and 2 Universities will develop a prototype benchtop instrument that will rapidly (< 30 min) detect bacteria and characterize key antibiotics resistance profiles of ESBL (extended spectrum beta lactamase) and carbapenemase producing GNB directly from the patient urine at the point of care in outpatients and hospitals at a low cost (~20 €/test) and with near 100% sensitivity and specificity.Key factors to success are:1.The consortium has an established collaboration through other projects2.The starting point, builds on previous knowhow and the reader, cartridge and bioassay technologies developed within previous collaborations.3.The “uncomplicated” raw urine sample material and the choice of technologies will ensure reaching the ground-breaking end goals in terms of assay time, cost, sensitivity, specificity and ease-of-use.4.The designs, materials and processes used are familiar to regulatory authorities, which enable approval by e.g. FDA.5.The 3 SMEs have experience in developing and bringing diagnostics products to the market.The project will lead to 1) a complete, tested, POC system, and 2) a tailor-made software algor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'AI profiling for smarter customer targeting' (ADMANTX).

assistant: **Concept**

Audience profiling is one of the key activities for marketers and brands in order to deter-mine interest profiles of their customers and their propensity to click/buy and therefore make smarter business decisions. Profiling is used in many areas, from e-commerce, to customer management and digital advertising (a market that moves over $228 billion worldwide). However, keyword-based current solutions come short in terms of accuracy (only 63% of context understanding the human way), while solutions using third-party data will become obsolete with the GDPR coming in action this May. ADmantX is a smart data provider that facilitates advanced brand planning and targeting within the digital advertising industry. We have 20 years of experience in context analysis for targeted online advertising, using semantic tools and proprietary patented NLP technology that makes our solution the most efficient on the market, understanding and analysing consumer data in a human-like manner.  Our AI profiling is using a combination of semantic + keyword based analysis and including an emotional and sentiment module we can obtain 95% accuracy, increase by 200% CTR, and by 300% brand awareness. Furthermore, by basing our solution in first-party customer data only, we are the only EU-company that is fully GDPR compliant. AI Profiling results have been consolidated with initials A/B tests with major companies from our current clients (Sky Italy) and our focus in now on providing better visualization tools, scaling, integrating with major bidding platforms and reach new markets outside EU, getting a €5 million accumulated profit and 2,38 ROI by year 5.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ROLE OF PFKFB3 IN THE REGULATION OF THE CELL CYCLE AND TUMORIGENESIS' in the context of a Seventh Framework call.

assistant: **Objectives**

Cancer is one of the leading causes of death in Europe and one of the highlighted issues in the 7th Framework Programme. Understanding the molecular mechanisms of cancer is expected to contribute to the development of better therapeutic approaches. In this project, the applicant proposes to examine the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) and its product, fructose-2,6-bisphosphate (F2,6BP), in the regulation of the cell cycle and tumorigenesis. Increased glycolysis is a key metabolic phenotype of cancer. Oncogenic stimuli increase F2,6BP, an activator of the first irreversible step of glycolysis. Previous studies have suggested PFKFB3 to be the dominant source of F2,6BP and the culprit behind the high glycolytic activity in tumors. The applicant has recently demonstrated that PFKFB3 localizes to the nucleus, where PFKFB3-mediated synthesis of F2,6BP stimulates cells to proliferate without a significant effect on glycolysis. He then discovered that F2,6BP in the nucleus activates cyclin-dependent kinases, decreases the expression of the cell cycle suppressor p27, and increases the expression of cyclin D3. These and other previous results obtained by the applicant suggest that tumor cells may need PFKFB3 and F2,6BP in the nucleus in order to couple glucose uptake with cell division activity in the nucleus. The objectives of the project are as follows: 1-To ascertain the role of PFKFB3 in the regulation of the cell cycle and cell cycle proteins; 2-To determine if there is a genetic/functional interaction between PFKFB3 and cyclin D3, and 3-To determine the in vivo interaction of PFKFB3 and p27, and whether PFKFB3 is required for tumor susceptibility induced by p27 deficiency. This project is expected to help the applicant continue his car
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Health and Environment Network'.

assistant: **Innovation**

To protect the health of populations and individuals, policies need to integrate environmental and health issues. The aim of HENVINET is to support such informed policy making. HENVINET will review, exploit and disseminate knowledge on environmental health issues based on research and practices, for wider use by relevant stakeholders.Further, it will lead to validation of tools and results with emphasis on the four priority health diseases of the European Environment and Health Action Plan (EHAP) 2004-2 010, and will provide structured information overview that may be utilised by other actors relevant to Environment and Health Strategy. Building on previous research and policy initiatives such as AirNET, CLEAR, PINCHE, INTARESE and SCALE, HENVINET will collect, structure and evaluate material and present it in a consistent manner, which will lend itself to transparency and identification of knowledge gaps.HENVINET will establish an overview of results, activities, projects and tools existing in Europe and will promote stakeholder networking through workshops and annual project meetings. Knowledge, best practices and decision support tools will be reviewed to allow wider exploitation by the relevant stakeholders such as policy makers. Recognizing that dissemination of knowledge, best practices and decision support tools is crucial in supporting the implementation of the EHAP, the project will define ways to disseminate information in collaboration with main stakeholders, with emphasis on the needs of users of information, more than of those producing it.To allow for efficient data gathering, information exchanges, and targeted dissemination, the project will utilise state-of-the-art Internet solutions and methodologies. To further promote interact ions with stakeholders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Active and Adaptive: Reconfigurable Active Colloids with Internal Feedback and Communication Schemes' (2014-2020).

assistant: **Innovation**

The vision of creating autonomous materials constituted of microscale motile units promises to disrupt a broad range of technologies but is still far beyond our reach. Inspired by nature, these materials are active, i.e. they convert available energy into functions, and adaptive, i.e. they respond to stimuli by reconfiguring via internal feedback and signalling schemes. In order to progress, we need to rethink the way in which we design, fabricate and control synthetic active units, aka active colloids or artificial microswimmers. I propose an innovative approach that combines colloidal synthesis, assembly and actuation with nanofabrication and the implementation of feedback to realize a new class of active colloids. Borrowing ideas from soft-robotic systems, we aim to realize and study “cyber-free” artificial microswimmers, which, in addition to on-board energy conversion, present internal degrees of freedom allowing for sensing, feedback and communication pathways ultimately to be regulated without external intervention. In particular, we will: 1) Numerically and experimentally implement feedback schemes to regulate single-particle motility and collective behaviour based on control theory. 2) Use a unique combination of capillary assembly and two-photon nanolithography to create shape-shifting active colloids that autonomously regulate their motility based on stimuli orthogonal to their propulsion schemes. 3) Create “transmitting” and “receiving” active colloids, sending and sensing chemical signals (pH changes), to regulate their motility. By introducing strong coupling between particles, and with stimuli beyond classical colloidal interactions, this proposal will enable a forward leap in the study of the emergent physics of active systems, as required to realize the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Science Friction' (SCIFRI), addressing dissemination and exploitation.

assistant: **Impact**

There is no fundamental law that dictates the necessity of losing energy in a sliding contact. In spite of its apparent simplicity, we have a relatively poor understanding of the mechanisms that determine how energy is lost when two bodies are forced to slide over one another. The SciFri project will launch a research attack on friction that will not only deepen our fundamental insight into this important phenomenon but also involves the development of several strategies to significantly lower or ‘lose’ friction under practical circumstances."" We will address in detail how energy is really dissipated on the atomic scale when sliding objects slip over a single lattice spacing."" We will bring friction to a halt by employing two mechanisms that we have explored recently on the atomic scale: superlubricity and thermolubricity."" Scaling up the two friction-lowering effects to the macro-scale will be attempted by a combination of two completely novel approaches. One is the use of special coatings, namely single monolayers of graphene or hexagonal boron nitride. The other involves a specific nanopatterning of the contacting surfaces."" In our friction experiments and modeling we will cover the full range of length scales, from the atomic regime all the way to the practical scale of so-called MEMS devices. This will prove to be an essential element in the extrapolation of nanoscale behavior to friction on a practical level. We will further compare measurements in uncompromised (ultrahigh) vacuum with observations under controlled ambient conditions, in order to explore the role of the atmosphere.""