RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Genomic selection of forage legumes' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Lucerne (Medicago sativa) is the main forage crop in southern Europe and could gain further importance for water- and energy-efficient crop-livestock systems in the context of climate change, especially if its drought tolerance could be enhanced. The objective of the research work is to improve its forage yield and persistence and its forage quality for moisture-favourable and severely drought-prone environments, through genomic selection models developed from a genome-wide set of molecular markers. Genomic selection, which is particularly useful to select for complex, quantitatively inherited traits, has never been applied to forage legumes. Its current application is made possible by the recent development of sufficient genomic resources by the outgoing institution (the Noble Foundation, Ardmore, USA), where the genotyping work will be performed. Phenotyping under moisture-favourable and severe drought-stress conditions will be carried out in the return institution (CRA-FLC, Lodi, Italy) exploiting its platform of large artificial environments. Quantitative trait loci (QTL) for the target traits will also be identified, and different strategies and techniques for defining marker assisted selection procedures will be compared.The objective of the training activity is to strengthen and widen the competences of the candidate in genomics and molecular breeding, with regard to: i) optimization of genotyping as a function of marker type, available resources, research objectives, and plant material and reproductive system; ii) statistical analysis of marker-trait association and QTL location for different breeding systems and experimental situations (biparental mapping populations, association mapping, bulk segregant analysis, etc.); iii) definition and validation of genomic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Synthetic Forager' (SF) targeting Seventh Framework.

assistant: **Abstract**

The single overarching goal of the SF consortium is to identify the neuronal, cognitive and behavioral principles underlying optimal foraging in rodents and to implement these principles in a real-world foraging artefact or the Synthetic Forager (SF.01). SF.01 constitutes a novel biologically based cognitive technology for autonomous exploration and foraging in real-world man-made indoor and outdoor environments. SF exploits our growing understanding of exploration and foraging behavior in rodents, advances current theories of the neuronal and behavioral organization of foraging and transfers this understanding towards the construction of novel real-world synthetic cognitive technologies. <br/>The behavior and neurophysiology of foraging will be studied in rodents behaving in automatically controlled multi-modal environments, fully controlled using an advanced experimental technology developed by the consortium. The overall integration of the perceptual, cognitive and behavioral control systems will be accomplished using a Distributed Adaptive Control (DAC). The perceptual, cognitive and behavioral control systems of SF will be based on statistical analysis and detailed game theoretic models. The SF control systems are validated against the behavioral and physiological data. The SF phenotype comprises a high-mobility robotic platform equipped with visual, auditory, olfactory and tactile sensors. The SF will be evaluated in a number of stringent benchmarks ranging from robot equivalents of rodent foraging tasks to simulated de-mining.<br/>The approach and technologies developed in SF will have long-term implications to areas including: cleaning robots, search and rescue systems, terrestrial and planetary exploration, delivery systems, autonomous transportation systems, m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Customer-Oriented Product Engineering of Micro and Nano Devices' (CORONA).

assistant: **Concept**

The competitiveness of EC companies in micro and nano technologies (MNT) very much relies on short time-to-market. That is true in particular for collaborative, distributed design and fabrication scenarios typical for an area where SMEs are strongly involved. Reduced time-to-market can only be achieved by faster product engineering. MNT product design and fabrication process development is an experimental task making use of key experiments or past experience to iteratively improve the engineering flow until a satisfying result has been reached. It is the objective of this project to contribute to ICT-based product engineering for MNT by: a) supporting integrated, distributed, multi-site product development with the customer in lead and control of the process, b) providing comprehensive and secure access to knowledge-bases for design and fabrication knowledge, c) offering ICT infra structure and tools needed to support customer services, design assistance and fab integration. The project work will provide contributions to: a) Developing a product engineering methodology and implementing it as a knowledge based, networked cooperation framework for customers, designers and manufacturers, b) Developing tools for an integrated design flow from the idea to the final product introducing tools to combine behaviour-oriented top-down and fabrication-oriented bottom-up design flows, c) Demonstrating the effectiveness of methodology and tools by realising example products. This work will contribute innovations in integrated design and production methodologies, ICT to assist and partially automate concurrent layout and process flow design, and knowledge-bases for customer services and fab data exploration. The consortium includes companies, in part SMEs, and institutes that contribu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Highly innovative strategies for vaccination to poverty related diseases' (INNOVAC).

assistant: **Innovation**

The Innovac project comprises seven partners of whom two are SMEs. Due to the number of SMEs the project will be coordinated by an academic partner. SMEs will have rights of first refusal to the commercial exploitation of the work they participate in.  The consortium will develop three platform technologies that will be used for novel and highly innovative methods for vaccination against two of the most important poverty related diseases, TB and Malaria. An important aspect to this proposal is inclusion of a vaccine-producing SME from a developing country.  The three platforms are  1) Bacterial spores. Robust and heat-stable bioparticles with proven efficacy as mucosal vaccines,  2) Intracellular & Invasive bacteria including E. coli strains and Mycobacterium bovis (rBCG),  3) S-layer protein conjugates and S-layer protein coated liposomes, Innovac will focus on discovery activities including proof of principle studies to show Ag expression, testing of vaccines in vitro as well as challenge experiments in vivo.  The project will test and evaluate highly novel strategies for vaccination using recombinant systems, some in their infancy while others more developed.  This project will include construction of vaccine vehicles, their evaluation in animal models, challenge experiments and finally safety tests where appropriate to take potential vaccines to the stage of clinical evaluation. Inclusion of a commercial enterprise from a developing platform will enable technology transfer to that partner as well as resources to the European partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'System-wide analysis of regulatory processes that mediate at the boarder of metabolome and proteome' (METABOLICREGULATORS).

assistant: **Innovation**

The metabolic network has a modular architecture, is robust to perturbations, andresponds to biological stimuli. The balance of the network, and the passageway ofnetwork substructures to operate at different activity, requires intensive interactionsbetween the metabolic network, the transcriptome and the proteome. However, thebiochemical mechanisms monitoring the metabolic network are only barely understood.Changes in network activity are often mediated through so called reporter metabolites:general -network interconnecting cofactors and reaction substrates - and specific pathwayintermediates. These metabolites bridge the gap between the small molecule andmacromolecular universe of the cell.Here we propose combining systematic yeast genetics with targeted metabolomics andproteomics to understand mechanisms of metabolic regulation on a genome-scale level. Inprinciple, we will elaborate multiple reaction monitoring (MRM) assays that facilitatequantification of enzymes and intermediates of selected metabolic pathways via liquidchromatography tandem mass spectrometry. The analysis will be performed on metabolicprocesses that influence aging; those will be analyzed and the results validated bychemical-genetic profiling and competitive lifespan experiments.The anticipated results will yield in a system-wide picture of interactions between themetabolome and regulatory components of the cell. Furthermore, it will identify novelgenetic and biochemical interactions of the aging process. Understanding thesemechanisms will stimulate new research directions in Systems Biology and support thedevelopment of therapeutic strategies against diseases of aging.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative abradable/abrasive materials for improved energy efficiency in Gas turbines' under Fifth Framework.

assistant: **Concept**

In the present project we plan to improve the energetic efficiency of gas turbines. This task will be accomplished by developing improved abradable seals to reduce the shroud/rotor gap in order to reduce back flux of gases in the high temperature combustion region of the turbine. These materials will have to be able to resist to high temperature, erosion, and oxidation, as well as to provide easy and controlled abrasion. They will also have to be cost effective and show the possibility to be manufactured by methods compatible with industrial manufacturing.Our calculations show that by means of these materials the turbine efficiency can be increased of at least 1% over present day technology, that is providing an overall efficiency improvement of 0.3%- 0.5% depending on the engine size. This improvement will result in a reduction of CO2 emission in the atmosphere of at least 0.2-0.3MTons/Year and higher as the technology is adopted worldwide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Human “mini-liver” stem cell culture systems:  from mechanisms behind liver cancer origin and recurrence to new therapeutic treatments' (2014-2020).

assistant: **Concept**

Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the human population. But at present, there are no good in vitro models for HCC. Thus, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive HCC pathogenesis and there are only limited therapeutic options. In this project, our aim is to establish and characterize physiologically relevant 3D-liver cancer stem cell models and use them to increase our understanding of the mechanisms behind liver cancer with the final goal to develop anti-cancer strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart Ski' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Smart Ski is a new breakthrough in ski industry, first after the introduction of carving concept in 1990s, which was also initiated by this same project team.Smart Ski is an IT-based pair of skis. Its sliding properties, driveability and bottom surface friction can be managed by skier via smart phone, according to his/her skiing skills, weather and ski terrain. This results in all-in-one ski, for all types of skiers. Smart Ski can also fold, so it is much less bulky. Such customization directly eases users' problems with limitation - of rigid current ski solutions, and of storage space. In future, safety and software functions will be added.Commercial potential is global - the main objective is to push through a new skiing revolution. That's why we won't develop our own commercialization, but will rather sell license to big 6 market leaders with existing sales and marketing channels, brands and global presence (Atomic, Rossignoll, Fischer, Elan, K2, HTM). First feedbacks for our prototype by their R&D departments were very positive. Some even estimated that embracing our solution will reduce their ski production costs by 30% and increase recyclability of production waste to 80%, in comparison to current state of the art. Our model also enables them to keep their brands, graphic designs, etc., and only buy know-how. This is a direct trigger for market leaders to form win-win partnerships with us.Smart Ski thus directly responds both to end-user needs, and to targeted buyers' needs. We estimate to realize 23 mio € revenue in first 5 years through license transfer fee, fee for each sold pair of skis, and component sales.In the feasibility study we need to 1-finish testing and developing of prototype, 2-develop in-depth market study with end-user aspects, 3-activate marketi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The nuclear pore connection: adaptor complexes bridging genome regulation and nuclear transport' to be submitted under Seventh Framework.

assistant: **Abstract**

Nuclear pore complexes (NPCs) form macromolecular assemblies in the nuclear envelope and mediate  bidirectional cargo movement between the nucleus and cytoplasm. Recent evidence suggests that NPCs are not merely transport channels but act as gene regulators. Studies in yeast demonstrate that inducible genes can reposition from the nuclear interior to the nuclear periphery upon activation. At the periphery activated genes engage in physical contacts with nuclear pores. Targeting and tethering of genes to nuclear pores involves multifunctional adaptor complexes, which are thought to couple chromatin modification, transcription and mRNA export. Knowledge of the structure, dynamics and evolution of these adaptor complexes is key to understanding how NPCs control nuclear gene positioning and gene expression. I propose to systematically dissect the architecture and function of NPC-associated adaptor complexes. Our studies will be a unique combination of biochemical and structural approaches in three different model organisms. I anticipate, that this line of research will create a powerful basis to address a number of key questions in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PhD Training Network on Durable, Reliable and Sustainable Structures with Alkali-Activated Materials' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

DuRSAAM is a collaborative PhD framework creating a critical mass of experts skilled in innovative alkali-activated material (AAM) concrete, as a key enabling technology for a sustainable and resilient built environment. AAM technology presents a new generation of materials, ideally conceived to respond to the need for more efficient, durable, eco-friendly and reliable construction, and utilizing by-product resources as raw materials. Modern concrete will be produced with low carbon footprint (CO2 emissions reduced by 80%), lower energy consumption and reduced use of primary resources (>1.5 t raw materials are quarried per t Portland cement clinker; this will be reduced by >60%), and with an addressable market for AAM binders of 5 B€/yr. DuRSAAM answers unmet industry demands, to facilitate emerging AAM technology for continued market entry and to unlock its potential in society. The consortium brings together 7 academic and 15 non-academic partners, to excel in the scientific development and exploitation of AAM concrete, advancing design, modelling and practice beyond the state-of-the-art. It holds a unique focus on: (1) today’s concerns of users and engineers that the durability and sustainability of AAM concrete is yet insufficiently quantified; and (2) provision of an AAM technology for rehabilitation of structures to meet the growing demand for renovation, to be developed in parallel with AAM for new concrete structures.The network will deliver world-leading training in this multidisciplinary field through 13 PhDs in interrelated aspects of AAM concrete, fibre reinforced high-performance concrete, and textile-reinforced mortar, as well as sustainability assessment. The outcomes will be instrumental in delivering a sustainable future in Europe’s construction industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Intercontinental Migrants and Pathogens in the Portuguese Empire: a biomolecular approach to diet, nutrition and mobility in the early globalized world'.

assistant: **Objectives**

Intercontinental Migrants and Pathogens in the Portuguese Empire: a biomolecular approach to diet, nutrition and mobility in the early globalized world The early modern period (15th-19th C) saw the birth of the so-called early globalization and for the first time different continents were linked by international routes with an unprecedented frequency and scale, creating an interconnected world and global market. The Portuguese Empire was one of the central actors in the transfer of plants, animals, culture, human populations, technology and diseases across the Atlantic Ocean, a process known as the Columbian exchange. In particular, the transfer of foods between the two sides of the Atlantic is one of the most significant events in the history of economic development of the last two centuries.The introduction of new crops such as potatoes in Europe, or intensive cultivation of sugar and coffee as well as the introduction of livestock in America, had measurable repercussions on the welfare of European countries, however, their real contribution to the diets of the general populations is unclear. EMPIRE will elucidate the history of global diet and oral health during transatlantic travels using palaeoproteomic analyses of ancient dental calculus and characterise people’s overall diet on the European and South American sides of the Atlantic through isotopic analysis of bulk bone collagen and lipids. This fellowship will provide evidence of diet and health of ordinary people who are often left silent during historical transitions which tend to focus on social elites or large-scale political narratives. The innovative approach in this study may open the door to investigate a wide variety of pressing archaeological questions in countries with a similar colonial past.


**Keyw