RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Open INformation environment for knowledge-based collaborative PROcesses throughout the lifecycle of a building'.

assistant: **Concept**

The InPro project will completely transform the Early Design phase of a building (new or renovation) project. At this influential phase, which represents only a fraction of the lifecycle of a building, decisions are made that determine over 70% of the total lifecycle costs.The transformation will be achieved through radical Early Design processes, supported by breakthrough innovations in business concepts and ICT solutions that integrate four crucial aspects of Early Design:- Open and flexible collaboration between all stakeholders of the building value chain- Design from a lifecycle perspective- Decision support to make informed choices" based on knowledge of each decision's consequences on the building lifecycle- Early planning of build and operation processes based on computer enabled simulations of smart digital prototypesThe consortium covers the whole construction value chain and is lead by five large and innovation-driven companies of the sector. InPro also includes a number of renowned Europe a research organisations in construction, industrial processes and ICT, plus leading software companies and standardisation experts. It is also supported by the InPro Research Cluster with already 30 active members. With an estimated budget of 17 million euro over four years, InPro gathers a strong combined mass of industrial leadership and scientific excellence.InPro will have a significant impact on lifecycle costs, sustainability, inclusion of construction workers and low-tech SMEs in the Information Society, take-up of multifunctional and nano materials, and much more. The research work is accompanied by roadmaps and strategies for a widespread take-up of innovation. InPro will be a first powerful step in a paradigm shift in the European construction sector to using kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Going digital: tools for identification and support for neurodevelopmental disorders within the transdiagnostic framework' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Individuals with neurodevelopmental disorders (NDDs) show highly heterogeneous behavioural, cognitive and brain profiles with much larger overlap between, e.g., dyslexia, dyscalculia and attention-deficit hyperactivity disorder (ADHD), than assumed by current diagnostic approaches. It remains unclear how the individual profiles of deficits and strengths result in child specific idiosyncratic development. Besides relying on discrete categories, the current diagnostic approaches assume relatively stable NDD symptoms across development while recent findings suggest more dynamic changes in the symptoms across development. The interdisciplinary and inter-sectoral Tools4NDDs consortium aims to employ recent technological advancements to better understand the heterogeneous and dynamic nature of NDDs. Our consortium utilizes the advances in transdiagnostic research, as well as the potential of digital technological solutions to improve diagnostic and intervention tools for NDDs. The general objective is to better integrate the transdiagnostic framework in translating empirical findings to available and emerging tools while taking into account children’s divergent sociodemograpic backgrounds. Knowledge transfer, training and research on this is carried out through secondments, online work groups and library as well as yearly workshops. Our transdiagnostic approach has great potential in improving both the understanding of the dynamical mechanisms underlying NDDs, and ultimately, the development of personalized diagnostic practice and intervention designs. As long-term outcomes, to promote much needed innovations towards early, personalized, and effective identification and support for children with NDDs, thereby improving their quality-of-life.


**Keywords:** Neurodevelopmental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Switching the disease off: Effects of spatial and temporal inactivation of mutant huntingtin in Huntington disease', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Huntington Disease (HD) is an autosomal dominantly inherited neurodegenerative disorder, which is caused by an expanded CAG repeat in the huntingtin gene. Mutant Huntingtin (mhtt) is expressed ubiquitously in the brain but the most affected region is the striatum. Marked atrophy also occurs in other brain regions such as the cortex and the hypothalamus. The latter has been linked to disturbances in sleep pattern, energy metabolism and emotion, all of them non-motor symptoms of HD that occur early in disease. In the project SWITCH-HD we will, for the first time, analyse, which mhtt containing brain area is causing which symptom in HD. We will investigate the role of mhtt in the striatum and in the hypothalamus by down-regulating mhtt in these brain regions at different disease stages using lentiviral delivery of Cre recombinase into a unique transgenic rat model of Huntington disease (BACHD rats). The effect of switching off mhtt in these brain regions on behaviour, metabolism, neuropathology, neuroimaging and potential biomarkers will be investigated. Translation of the results of this study to humans will allow to develop more specified treatments against HD. SWITCH-HD brings together the expertise of the SME JSW Life Sciences (JSW, Austria) and the University of Tübingen (EKUT, Germany). JSW will contribute and transfer its expertise regarding stereotactic applications, gene delivery by lentiviral vectors and behavioural studies. EKUT will contribute and transfer their expertise in regard to generation and comprehensive characterisation of transgenic rat models of HD. Co-operation and transfer of knowledge is dedicated to gaining new insights relevant to pathogenesis and treatment of HD as well as the establishment of new tools. Transfer of knowledge will be implement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dissecting the mechanisms of miRNA function' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

miRNAs are crucial regulators of gene expression that target more than half of eukaryotic genes and play a role in human diseases, including cancer and neurological disorders. Therefore, it is important to understand the molecular mechanisms underlying miRNA-mediated repression. miRNAs act as guides recognizing their target mRNAs by partial complementarity and recruiting a complex of proteins that represses mRNA expression. In this complex, proteins of GW182 family are the key effectors mediating repression. We have shown that GW182 recruits deadenylation complexes via novel protein motifs (W-motifs), leading to translational repression and mRNA deadenylation. Translational repression by deadenylases occurs independently of deadenylation by a mechanism, which is still mysterious. Thus, our first goal will be (1) to analyze the mechanism of translational repression by deadenylases and its contribution to miRNA silencing. Our preliminary data show that W-motifs recruiting the deadenylation complex (CCR4-NOT) are not restricted to the GW182 family and can be found in other proteins involved in RNA metabolism. The roles of W-motifs in these proteins are completely unknown, but important to investigate if we want to better understand the mechanisms of RNA silencing. The fact that CCR4-NOT is involved not only in mRNA deadenylation and translation, but also in other steps of RNA metabolism, including transcription, RNA processing and export, suggests that proteins with W-motifs have the potential to orchestrate gene expression at different levels. Thus, our next goal will be (2) to investigate more broadly the full repressive potential of W-motifs. In a wider context, this proposal will explore the roles of miRNAs in such important and global processes as subcellular localiza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Electrical knowledge development' (ELKD).

assistant: **Innovation**

The main aim of this definition phase of the project is to develop a high level set of enterprise requirements for both P.P.C. and Vattenfall about the re-structuring and reengineering of critical processes within the Electricity Supply Industry. This definition will have a multifaceted role specifically it will seek:- to define specific requirements for both P.P.C. and Vattenfall for specific business processes requiring re-engineering- to provide the overarching rationale that binds the application areas of P.P.C. and Vattenfall for the future pilot project- to indicate the kind of generic business processes that will be applicable not only to P.P.C. and Vattenfall but also to other European companies within the ESI sector- to produce a definition of the pilot study project which will form the basis for evaluating a continued phase of the project.The definition phase of the project will be entirely motivated by industrial concerns, needs and aspirations. The two selected business areas are those of customer service" and "strategic planning" for P.P.C. and Vattenfall respectively. Both P.P.C. and Vattenfall are large organisations with complex business procedures. They have strong needs for optimising them in order to improve their competitiveness.The objective of P.P.C. with respect to the "customer service" function is to improve customer service and achieve large cost reductions in the way that they currently provide such a service. These reductions have already been quantified through an in-depth study which looked at only one of the many aspects of "customer service" namely, billing: according to the study it is estimated that a reduction from 20 days to 5 days in this process will yield an immediate saving of approximately 30 MECU. Another area within "customer s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Feasibility study for an innovative “Regenerative Atmosphere Packaging” for fresh chicken' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Packaging has improved the safety and quality of poultry products. Currently, MAP (Modified Atmosphere Packaging) is themost widely used packaging system. MAP seals fresh produce in a tray with a controlled atmosphere that contains gasesthat slow the degradation of the product.SCIENCEPACK has designed and developed an innovative “Regenerative Atmosphere Packing” (RAP) that offers aneffective alternative to the conventional MAP system. The key to this innovation is that, thanks to a specific tray design andactive coating (AC), CO2 is slowly released from the packaging. This allows the tray to regenerate the product preserving.FRESHRAP’s represents a huge opportunity for our company (SCIENCEPACK) to commercialise an innovative solution thatwill increase the shelf life, quality and the safety of fresh chicken parts. This offers us the opportunity to launch a newproduct on to the large and growing packaging tray market.FRESHRAP will promote the efficient use of resources and reduce food waste by extending 1-1.5 days the shelf-life of freshchicken, and removing the need to dispose of opened, in-date chicken trays. 60% of Europeans throw away opened chickenmeat, causing approximately 360,000 tonnes of waste per year in Europe. We offer the possibility to end this waste.FRESHRAP will also help to ensure that food remains safe to eat for longer, reducing the number of customers sufferingfrom food contamination (Campylobacter).Finally, FRESHRAP will also support packaging companies by reducing the high capital and operational costs of MAPpackaging.Initial market projections suggest that FRESHRAP will achieve sales of 5 million units in the first year of commercialisation,growing to 30 million by 2022, earning profits of over 2M€ and a ROI on project investment of 94%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improving the resolution of Neuroinflammation during repetitive mild Traumatic Brain Injury with dietary fatty acid Derivatives' (INBID) under Horizon 2020.

assistant: **Objectives**

Traumatic brain injury (TBI) represents a major health problem in Europe. Repetitive mild TBI (rmTBI) is a particularly dangerous form, due to its prevalence and limited overt clinical signs. This is concerning as rmTBI can lead to cumulative injury and is an established risk factor for dementia. Repetitive mTBI has been referred to as a ‘hidden epidemic’, but little is known about the pathological mechanisms. The project aims to address a major clinical need by identifying and validating new targets for the treatment of rmTBI. Microglia are critical components of neuroinflammation and are promising targets for intervention. It is now understood that nutrition and the amount of polyunsaturated fatty acids (PUFAs) contained within the diet can have profound effects on brain inflammation. Furthermore, specialised pro-resolving mediators derived from PUFAs have shown promise as interventions for disease.We hypothesise that the microglia-mediated inflammatory response to mTBI can be affected by manipulating PUFA levels to reduce the harmful, cumulative effects of a second mTBI. We will use a clinically relevant model of rmTBI in mice and investigate the resolution of inflammation during the period between injuries. These studies will be the first to integrate multiple parameters of microglia-mediated inflammation, combining transcriptomic and lipidomic profiling with unbiased network analysis to describe the resolution of inflammation in mTBI. Finally, by targeting of the most important network parameters, we will attempt to speed up the resolution of inflammation and so reduce the impact of rmTBI. The joinedexpertise of the applicant (neuroinflammation and microglia), the host lab (nutrition, lipids, behavior), and the secondment lab (transcriptomics and microglia) will gu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Monitoring Arctic Glaciers and IceCaps from Space'.

assistant: **Objectives**

Sea level change is one of the major challenges for the next century. Historically, ice loss from mountain glaciers and ice caps has been the single largest contributor to the ~2 mm/yr sea level rise over the last century and 50% of this contribution has come from the Arctic. Recent studies show that they will continue to be one of the major contributors to sea level rise in the 21st century. There is, however, a large uncertainty associated with these estimates. Direct observations are sparse and some areas, such as the Russian Arctic, have been not surveyed at all. This project aims to combine GRACE gravimetry observations, ICESat and Cryosat-2 altimetry measurements, surface mass balance information from models and glacier discharge estimates in a joint statistical assimilation.The combination of these data will provide consistent, robust and adequately constrained time series of the mass budget of the Arctic region in the first decennia of the 21st century, at a quality which cannot be obtained from the individual data sets. It will yield a model-independent glacial isostatic adjustment solution and a rigorous treatment of uncertainties. This will greatly improve our insights of the response of Arctic glaciers to climate changes, their contribution to sea level rise and serve as a validation tool for the development of glacier components which are poorly represented in globally coupled climate models.During the first 2 years of the project, the applicant will be hosted by John Wahr at CIRES in Boulder, Co. The final year of the project will be spend at the Bristol Glaciology Center with Jonathan Bamber. Their unique experience with remote sensing of the cryosphere and the extensive knowledge of glaciology and other geophysical processes at the institutes and the bac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Models combining ecology and epidemiology-wild boars and swine fever' (1998-2002).

assistant: **Concept**

Post-doctoral fellowships in wildlife disease modeling The UFZ - Centre f. Environmental Research, Leipzig-Halle Germany, is offering two two-year fellowships for epidemiologists at the Dep. of Ecological Modelling (OESA). The OESA group has a team of more than 25 scientists working on modeling projects in theoretic and applied ecology. One aspect of current research is the management of pathogens in natural populations. The fellows establishes a new modeling project concerning the Classical Swine Fever in wild boars. The project orients towards the model-based evaluation and optimization of control strategies against CSF in wild-boars. The results of the modeling project will have an immediate impact on CSF control practices due to close contacts to veterinary health offices. For both fellowships the successful applicant must have a PhD degree and demonstrated expertise in modeling (animal) diseases. The fellow will hold the full responsibility for the epidemiological competence of the project. Applicants must be prepared to work in an international and interdisciplinary research team. First fellowship (start in 2002): The fellow will develop a model for the within-herd dynamics of CSF in wild-boar. The applicant must be intimately acquainted with the specifics of (wildlife) diseases. The fellow should be able to convert empirical knowledge into the conceptual framework of modeling. Skills in computer programming are advantageous but not necessary. Second fellowship (start in 2004): The fellow will evaluate the CSF control strategy on a between herd-level and should derive innovative new strategies for improvements. Therefore, the applicant must be acquainted with disease control strategies in wildlife, their shortcomings and political relevance. Also, competence conce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Political Dynamics of Slow-Onset Disasters: Contrasting Antimicrobial Resistance (AMR) and Ebola Responses'.

assistant: **Concept**

Disasters differ markedly in their speed and pattern of manifestation, which in turn greatly affects how researchers as well asauthorities interpret and respond to them. While theoretical innovations made by disaster researchers over the last centuryhave almost exclusively been developed for the study of large rapid-onset disasters, disaster assessments reveal thatelusive and slow-onset disasters affect more people on aggregate. I recently carried out a preliminary study suggesting thatslow-onset disasters have primarily been addressed as something ‘other’ than conventional disasters, and have fallenoutside of the scope of most disaster studies. We therefore lack theoretical frameworks capable of describing the policydynamics of slow-onset disasters, largely because existing studies focus on individual slow-onset hazards (e.g. climatechange, pandemics or droughts).In this project, I will address this gap by studying the ways in which two types of slow-onset disasters vary through a politicalresponse and health policy lens. By contrasting the political response trajectories of antimicrobial resistance (AMR) andEbola I will investigate how incremental slow-onset disasters (such as AMR) differ from cyclical ones (such as Ebola) withimplications for policy response. The project will be hosted at Roskilde University (RUC), Denmark.Empirically, the project employs a health sector focus where the global- and EU-level political response to AMR isjuxtaposed with the Ebola response using process tracing analysis. This provides both novel insight on how an incrementalslow-onset disaster (AMR) differs from a cyclical one (Ebola), as well as new knowledge on the dynamics of AMR andpandemic policymaking. The overarching puzzle and ambition of the action is therefore to understand how