RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Assessment of seismic potential in European large earthquake areas'.

assistant: **Objectives**

Foreseen ResultsThe first issue concerns (1) local seismic monitoring of the fault zones of Thiva - Oropos to the north of Athens (Greece) and Vlora - Debar in eastern Albania, and (2) upgrading of the telemetric seismograph network of Albania. As regards field observation, new neotectronic and paleoseismological data will be collected while their elaboration with advanced computing paleostress methods will contribute to modelling stress-field patterns and seismotetonics. Interpretations of shallow and deeper tectonics will be also approached by advanced magnetotelluric surveys in particular seismic zones. New probabilistic approaches will be tried for (1) the sensitivity analysis and correction of standard" seismic hazard assessment methods, (2) the detection of structural changes in the seismic process, (3) the simulation of earthquakes cycle, and (4) the comparative analysis of different approaches in use. Advanced artificial intelligence techniques integrating GIS and Expert Systems technologies will be tried for solving problems of earthquake forecasting and cluster analysis. ASPELEA is based on a highly interdisciplinary approach : seismologists, geologists, tectonicians, geophysicists, computer scientists, mathematicians will cooperate together to achieve the proposed tasks.The project ASPELEA is a cooperative effort involving partners from three EU countries (Greece, Italy, The Netherlands), four CCE countries (Albania, Bulgaria, Czech republic, Romania) and Russia and addressing the very important problem of assessing reliably the seismic potential and mitigating the associated hazards in European high-risk earthquake areas. Earthquakes are know to have affected seriously many European areas particularly Greece and other countries of the Balkan peninsula, Italy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The role of ubiquitination in stability and plasticity of the GABAergic synapse'.

assistant: **Objectives**

Proper brain functioning requires a balance between inhibitory and excitatory synaptic activity. This balance can be maintained by regulating the number of neurotransmitter receptors in the postsynaptic membrane. A major inhibitory synaptic receptor is the hetero-pentameric GABAA Receptor (GABAAR), which is stabilised in the synapse by the intracellular scaffolding protein gephyrin. Gephyrin, in turn, is recruited to and stabilised at the synapse by the adhesion protein neuroligin-2 (NL2). Regulation of synaptic strength involves lateral diffusion of GABAARs into and out of synapses, endocytic downregulation followed by either degradation or membrane re-insertion, and altering the size of gephyrin clusters. Altered GABAAR trafficking is implicated in neurological and psychiatric disorders, including epilepsy and excitotoxicity in ischemia. The underlying mechanisms, however, remain poorly understood.Ubiquitination is a well-known mechanism that regulates protein trafficking and turnover, however its role in stability and plasticity of the GABAergic synapse remains unclear. Preliminary work from the Kittler lab suggests that: 1) the ubiquitin ligase Unk plays a key role in ubiquitination of the GABAAR; 2) gephyrin can be poly-ubiquitinated and that its proteasomal turnover may be regulated by the de-ubiquitinating enzyme OTUD4; 3) NL2 can be mono-ubiquitinated, potentially directing its trafficking, and that the ubiquitin ligase Nedd4 may regulate this process. Thus ubiquitination may play several key roles in regulating the dynamics of receptor, scaffold, and adhesion molecules at the inhibitory synapse. Using molecular, biochemical, cell biological, and state-of-the-art imaging approaches I aim to study how ubiquitination of GABAARs, NL2 and gephyrin affects GABAAR tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Articular Cartilage Treatment with Injectable hydrogel is Valuable and long-term Effective' (ACTIVE) targeting Horizon Europe.

assistant: **Abstract**

Hy2Care brings a regenerative Injectable Hydrogel, of joint- and cartilage-mimicking composition, that is used to treat damaged cartilage. The cartilage defects are easily filled with a syringe during a standard one time arthroscopy. The hydrogel fill the defect, prevents ingrowth of scar tissue and allows the body to heal itself by creating true Hyaline cartilage, ensuring an optimal regenerated tissue. The high-quality regeneration provides the basis for a long lasting repair, postponing or even preventing the onset of osteoarthritis. The gel binds covalently to the surrounding cartilage ensuring integration of the new tissue. Revalidation is fast as the cartilage regrowth follows the degradation of the gel. The lasting repair not only prevents additional secondary treatments but also pain, disability and escalating follow-on costs. In submission of the last cut off of the EIC in october 2020 Hy2Care scored a 14.0 and recieved the seal of excellence.


**Keywords:** osteoarthritis,cell-technology platform,minimal invasive,traumatic focal defect,PMA/510k,cartilage regeneration,cartilage repair,tissue regeneration,joint preservation,regenerative medicine,sports medicine,injectable,biodegradable,in situ tissue engineering,joints,knee,hydrogel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Self-organizing Performance Prediction and Optimization for Large-scale Software Systems' (SPANDO), addressing dissemination and exploitation.

assistant: **Impact**

The scope of SPANDO (Self-organising Performance Prediction and Optimisation for Large-scale Software Systems) is to contribute to the development of decentralised self-optimising software systems. The project focuses on the conceptual foundations and engineering techniques on the use of run-time performance prediction models and self-organising adaptation strategies to achieve a decentralised performance optimisation of the system.Current research in the area of self-adaptive systems is moving towards solutions to adaptation problems with the aim to engineer systems that can quickly respond to changes without any human intervention. As systems are becoming larger and more complex, the adoption of solutions that are both decentralised and scalable is becoming increasingly important. Up to now, this research area has focused on producing approaches to support the actuation of decentralised adaptation actions, however the problem of deciding when and how to execute them is still challenging in a decentralised setting. SPANDO proposes to solve such problem by using performance prediction models that are being studied in operations research and applied probability research. The most common prediction models that are already being used at run-time are based on Continuous-Time Markov Chains. However, these existing techniques have scalability limitations due to the state-space explosion of the CTMC formalism.The SPANDO project will overcome these limitations by studying a new class of performance prediction models that can be evaluated in a decentralised way, without any explicit coordination. The proposed models will use formalisms based on ordinary differential equations, such as fluid and mean-field analysis, and have the particularity of being independent of the size of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Supporting the ERA-NET Learning Platform by creating a toolbox for the ERA-NET community'.

assistant: **Objectives**

The ERA-LEARN action will support the urgently needed learning process by generating tools that will be made available to the whole ERA-NET community. The consortium members are themselves fully involved in this funding instrument, being partners in 66% of all ERA-NETs. Thus, this consortium is well qualified to tackle this challenge. Based on a comprehensive analysis of existing and already validated procedures ERA-LEARN will facilitate the identification of recommended tools that are suitable for a broad use. In particular, ERA-LEARN will • facilitate mutual learning among ERA-NETs • provide guidance in aligning and harmonising the structures and procedures needed for efficient and simplified joint call implementation and selection of proposals, with a view to the development of a common framework for these activities • provide guidance in choosing the most appropriate funding mode • provide guidance in taking strategic decisions on which existing ERA-NETs to join and which new ERA-NETs to establish, thereby enabling optimum use of resources and instruments • facilitate a structure for monitoring the long-term evolution of the ERA-NET scheme, helping to create a durable interaction between funding programmes Eventually, the outcome will be a limited set of well accepted and therefore widely used guidelines, serving as a helpful reference and easily accessible library. The ERA-NET community will be enabled to select the most appropriate methods for specific situations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional genomics and proteomics in human molecular gerontology and geriatrics (development of ad hoc microarray, diagnostic applications and molecular screening) - (functionage)' (FUNCTIONAGE) targeting Fifth Framework.

assistant: **Abstract**

Human gerontology is entering the post-genomic era. We will clarify how genes associated with ageing affect the process of successful (longevity without overt diseases) and unsuccessful ageing (proinflammatory status, age-related diseases, disabilities) by applying advanced functional genomic and polemics on complementary in vitro models of human ageing, and on cells from centenarians and patients struck by major age-related diseases. With an SME we will develop and exploit a reliable multi-functional µ-array 'Seneschal' suitable for molecular gerontology in vivo and in vitro, and for diagnostic in geriatrics, to evaluate the pro-inflammatory status of patients, particularly those at high risk for impending disability, and their morbidity and chance for survival after stressful conditions (surgical operations). Moreover Seneschals will be commercialised for helping the development of novel cosmeceuticals/anti-ageing drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'LEAF: heaL thE plAnet's Future' (LEAF) targeting Horizon Europe.

assistant: **Abstract**

Starting from the encouraging results of the LEAF (heaL thE plAnet's Future) project in 2021 NIGHT edition, we are now proposing a step forward to increase the awareness on the importance of research and innovation, to improve trust in the researcher's work by effectively involving the society in experimenting science through 600 events. All activities will cover EU Green Deal topics (Farm to Fork, Biodiversity, Circular economy, Zero-pollution, toxic-free environments, Health & Wellbeing, Energy and resource efficient buildings, secure energy, sustainable and smart mobility). The main goal is to make science accessible and fun to everyone, thus generating a practical understanding of how to cope with climate change issues. The LEAF project will be developed in 21 cities in Italy, involving 39 partners with a series of events happening during the last week of September 2022 and 2023 thus including the NIGHT. LEAF 22-23 project will include a series of specific activities dedicated to schools to permit researchers to engage with teachers and pupils on challenges related to climate change, sustainable development, health and other issues related to the European Commission priorities such as the European Green Deal. In particular, in this edition we will reinforce the experience at school through a dedicated work package on researchers@school involving institutes located in small towns with difficulties in reaching NIGHT events. First year will be devoted to fulfill the achievements reached in last editions while in 2023 our main goal will be the improvement of project KPIs thanks to the validation of the researchers@school activity. The overall result will be a relevant increase in the awareness of why and how the researcher's work is relevant for the benefit of our curre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hemp for buildings' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To determine the potential for research into the testing of treated hemp shiv as a building material, either mixed with lime/lime and sand or with no admixtures. General areas of consideration include: Structural performance Resistance to moisture Compatibility when combined with traditional materials Thermal performance Vapour permeability Acoustic performance Fire performance Energy demand Comparative construction costings Demolition and reuse of materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Robust Quantum Computation with Geometric Phases' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Quantum information processing is an emerging research area where the quantum mechanical nature of physical systems is explored to improve the transmission and processing of information. In the case of quantum computation, specific algorithms use super-positions of quantum states that code information to achieve exponential speedup compared to conventional computers.The execution of such quantum algorithms in an actual implementation uses unitary transformations referred to as quantum gates to drive the system through the individual steps of the quantum algorithm. In the proposed project, we plan to design and implement such gates on the basis of geometric quantum phases. For this purpose, time-dependent control fields are applied to the system in such a way that it undergoes a closed circuit that brings it back to the initial state, up to a phase factor that depends on the geometry of the circuit. If the circuit is designed properly, this phase factor implements a quantum gate operation. It has been shown that the phase factors resulting from such circuits are immune to certain local fluctuations that may negatively affect the precision of conventional gate operations.Within this project, we plan to use this approach to design gates for one- and two-qubit operations and optimise them with respect to three main criteria: speed, robustness, and performance in the presence of noise. Experimental assessments of the performance of these gates will be carried out by NMR in liquids, which represents the most advance d implementation of a quantum information processor available today; results should be applicable to other implementations. The main benefit of this project will be an improved performance of quantum computers and a step towards reliable quantum information proces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Eco-friendly smart multifunctional composite coatings for long-lasting corrosion protection of magnesium and its alloys'.

assistant: **Objectives**

The world is moving towards sustainable economic growth and green technologies; therefore, the high specific strength, easy recyclability and lightweight of Magnesium (Mg) based materials make them potential options to minimize weight, save energy and reduce environmental issues. However, their poor corrosion resistance in aqueous and atmospheric conditions limits their widespread usage in many industrial applications. Enormous effort has been made to protect Mg and its alloys against degradation and improve their service time. Despite that, the questions related to their durability, longevity, biocompatibility, cost and environmental impacts must be resolved.  This scientific work aims to develop durable, multifunctional multilayer composite (MMC) coatings to provide long-term corrosion protection to Mg-based materials. Durability and long-term protection will be achieved by using eco-friendly materials and considering interfacial adhesion strength between substrate/composite within the multilayers and their surrounding environments. MMC coatings will be prepared to protect Mg-based materials against corrosion and give a visual response when the coating is damaged to achieve this scientific goal. MMC coating will consist of a self-assembled organic layer, a polymeric composite containing corrosion inhibitor and sensing agents loaded metal-organic frameworks (MOF) using a stimuli-responsive polymeric gatekeeper in a single layer and a top self-cleaning hydrophobic polymeric layer. They will provide adequate long-term corrosion protection of Mg-based structures by the synergistic effect of self-cleaning, passive barrier layers and on-demand release of active corrosion inhibitors from loaded MOF. Corrosion-sensing agents encapsulated MOF will monitor the onset of corrosio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Shaping the european research area: science policies for an enlarged europe' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

SEMMERING proposes a series of three conferences (Semmering Science and Technology Fora) and three Steering Committee meetings, which are to analyze national and European S&T policies in the context of internationalization. These meetings are designed to create the forum for better understanding and co-operation between the S&T communities within Europe. They will provide an arena in which policy-makers and civil servants on one side and experts and researchers on the other will discuss problems and issues surrounding the international co-operation in the field of science and technology, with special emphasis on trans-national aspects of the policies, evaluation culture and quality control and the issues of collaboration and networking in S&T. Through this dialogue, strategies will be devised for further co-operation and development of S&T policies in an enlarged Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Evolutionary biology of human and great ape brain development in cerebral organoids' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Humans are endowed with a number of advanced cognitive abilities not seen in other species. So what allows the human brain to stand out from the rest in these capabilities? In general, the brains of primates, including humans, have more neurons per unit volume than other mammals. But humans are also in the fortunate position of having the largest of the primate brains, making the number of neurons in the human cerebral cortex greatly expanded. Thus, the difference seems to be a matter of quantity, not quality. My laboratory is interested in understanding how neuron number, and thus brain size, is determined in human brain development. The research proposed here is aimed at taking an evolutionary approach to this question and comparing brain development in an in vitro 3D model system, cerebral organoids. This method, which relies on self-organization from differentiating pluripotent stem cells, recapitulates remarkably well the endogenous developmental program of the human brain. Having previously established the brain organoid approach, and more recently improved upon it with the application of bioengineering, my laboratory is in a unique position to carry out functional studies of human brain development. I propose to use this approach to compare developing human brain tissue to that of other hominid species and tease apart unique features of human neural stem cells and progenitors that allow them to generate more neurons and therefore a greater cerebral cortical size. Furthermore, we will perform transcriptomic and functional screening to identify factors underlying this expansion, followed by careful genetic substitution to test the contributions of putative evolutionary changes. In this way, we will functionally test putative human evolutionary changes in a manner n