RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genetics of Resistance to Malaria Parasites in the Mosquito Anopheles gambiae' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Anopheles gambiae mosquitoes are major vectors of Plasmodium falciparum, a protozoan parasite that causes the most severe form of human malaria in Africa. With an estimated 250 million infected people every year and another 3.3 billion at risk, malaria remains one of the biggest scourges of humanity. One of the promising approaches to fight malaria is the control of vector competence that determines the ability of a mosquito to transmit the disease. The fact that mosquito strains that are resistant to the parasites can be selected indicates that genetic factors in mosquitoes limit parasite development.Here we propose to use laboratory infection models to decipher the complex genetic networks that sustain mosquito resistance to P. berghei and P. falciparum. In these models, genotype-to-genotype interactions and environmental variability are limited, two features that are essential to efficiently dissect the genetic control of a complex trait. The parallel identification of loci conferring resistance to P. berghei and to P. falciparum will be crucial to unravel the conserved and species-specific aspects of mosquito   parasite interactions at the molecular level. We will further evaluate the contribution of the identified genes and networks to vector competence in natural mosquito populations. Because resistance naturally occurs in mosquito populations, this project has implications for the design of novel strategies and/or for the improvement of existing ones to reduce malaria transmission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Promoting and Monitoring Biomedical Informatics in Europe' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Biomedical Informatics deals with the integrative management and synergic exploitation of the wide ranging and inter-related scope of information that is generated and needed in healthcare settings, biomedical research institutions and health-related industry.Some key present challenges of Biomedical Informatics are:- The effective and synergic integration between computational methods and technologies supporting life sciences research (Bioinformatics) and the informatics supporting healthcare and medical research (Health or Medical Informatics).- The development of effective translational knowledge management approaches facilitating the application of knowledge arising from basic biomedical research into clinical practice.- The integration and joint exploitation of heterogeneous information stored in widespread repositories and diverse formats.- The development of innovative methods for the modelling and simulation of complex biological phenomena, as well as the corresponding computational applications.- The intersection between neuroscience and informatics (neuroinformatics).In this context, INBIOMEDvision aims to become a European-wide initiative intended to monitor the evolution of the Biomedical Informatics field and address its scientific challenges by means of collaborative efforts performed by a broad group of experts with complementary perspectives on the field. These efforts will certainly contribute to the strength and expansion of the Biomedical Informatics scientific community, particularly in Europe.INBIOMEDvision will develop a series of services and activities to serve the aforementioned purposes (inventory of resources and initiatives, state of the art reviews, prospective analyses, community-building actions and dissemination and training activities).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'STARTS Ec(h)o: fostering ECOlogically conscious and Human compatible digital technology' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In the digital age and the decades of societal and environmental emergency states that we live in, science, technology, and industry have hit the innovation ceiling. New approaches, alternative perspectives, and creative solutions to inspire progress and accelerate development are needed: Artistic thinking can provide the boost we need to tackle the great challenges of our times. Science, Technology and arts (S+T+ARTS for short) limn a nexus at which insightful observers have identified extraordinarily high potential for innovation. And innovation is precisely what’s called for if we’re to master the social, ecological and economic challenges that Europe is facing. STARTS Ec(h)o's main objective is building towards the triple transformation and developing artist-led approaches through creative experimentation and recognising the most successful ones: •The S+T+ARTS Prize will highlight and promote 90 outstanding technology-driven artistic projects and the achievements of the teams behind them towards the green transition and social sustainability.•Through S+T+ARTS residencies, artists will be enabled to develop 10 new pilots on human-centered and sustainable technologies in the fields of AI, high-performance computing, simulation & visualisation, digital twins, medical tech or circular economy.•An annual AIxMusic program at Sónar will create an international platform for pushing limits of digital technology and exploring the compatibility of digital with human values and needs through artistic thinking.Ars Electronica, Sonar, Salzburg Festival, Inova+, T6, French Tech Grand Provence, Technical University Dresden and Media Solution Center Baden Württemberg will stimulate arts-driven innovation that is human compatible and ecological consciousness and showcase outstanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Scalable Knowledge-Aware Image Caption Generation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Image captioning is the process of mapping a visual scene to a short textual description. Automating this process is vital for many computer applications, including information retrieval from visual data, computerized assistance to visually impaired people, and automatic tour guiding. State-of-the-art captioning systems are limited by their heavy reliance on visual contents. As a result, generated captions are often purely descriptive and miss important information that is needed in order to understand the image. This PoC project develops a captioning tool that will be useful for knowledge-intensive areas like Geography, Radiology or Art History, where captions need to include information that cannot be extracted from images alone. It builds on results of the ROCKY ERC AdG project, whose innovative captioning system integrates external knowledge into the captioning process. This allowed the ROCKY project to employ standard methods of image captioning, with a deep convolutional neural network (CNN) for image understanding and a Transformer network for language generation. Thanks to the external knowledge integration, the ROCKY captioning prototype gets substantially closer to human-generated captions than standard captioning systems that do not take external knowledge into account. This PoC project will use this result by implementing a knowledge-aware captioning system that is scalable for practical purposes. The project examines the feasibility of the ROCKY captioning method for Medical Imaging and Art History and implements it for one of these domain as a use case. The project will engage with experts in these domains, specify a practical captioning system, implement it as an open-source tool and test it in realistic situations. The anticipated value of this effort is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evolution of multicellularity and somatic cell specialization' (EVOSOM).

assistant: **Innovation**

The evolution of multicellularity allowed specialization of cells into functions that support rather than cause propagation. While yielding immense gain of function, the organisation of these somatic cells into tissues and organs required novel cell-cell signalling systems. We seek to identify the genetic changes that caused transitions to multicellularity and enabled cell specialization. We use genetically tractable Dictyostelia with multicellular structures that contain from 1 to 5 cell-types to address these fundamental questions. Dictyostelia evolved from unicellular Amoebozoa and are subdivided into 4 major groups, with most novel cell-types appearing in group 4. We found that gene expression patterns changed most frequently at the transition between groups 3 and 4, and that across groups ~10% of genes were alternatively spliced in the 5’UTR, indicative of promoter elaboration. Among known genes essential for multicellular development, those involved in intracellular signal processing were mostly conserved between Dictyostelia and unicellular Amoebozoa, while those encoding exposed and secreted proteins (ESPs) were unique to Dictyostelia or groups within Dictyostelia. Starting from a hypothesis that diversification of ESPs and gene regulatory mechanisms are major drivers of multicellular evolution, we will place unicellular relatives of Dictyostelia under selection to induce multicellularity, establish which genes are most changed in evolved populations and whether this involves ESP families that are also most changed in Dictyostelia. We will overexpress altered genes in unicellular forms to assess whether this induces multicellularity. We will retrace evolution of cell specialization by lineage analysis and phenotyping and seek correlations between cell-type innov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecological and Multifunctional Composites for Application in Aircraft Interior and Secondary Structures' (ECO-COMPASS).

assistant: **Innovation**

Composites are important materials used in aircrafts due to their excellent mechanical properties combined with relatively low weight enabling the reduction of fuel consumption. Expensive carbon fibre reinforced plastics (CFRP) are used in fuselage and wing structures and increasingly replace classic metals. Glass fibre reinforced plastics (GFRP) are mainly used for the interior panels. All these composite materials used in aviation have one thing in common: they are man-made. Renewable materials like bio-fibres and bio-resins are under investigation for a long time for composites but they did not made it into modern aircraft yet.The project ECO-COMPASS aims to bundle the knowledge of research in China and Europe to develop ecological improved composites for the use in aircraft secondary structures and interior. Therefore bio-based reinforcements, resins and sandwich cores will be developed and optimized for their application in aviation. Furthermore the use of recycled man-made fibres to increase the mechanical strength and multifunctional aspects of bio-composites will be evaluated. To withstand the special stress in aviation environment, protection technologies to mitigate the risks of fire, lightning and moisture uptake will be investigated. An adapted modelling and simulation will enable the optimization of the composite design. Electrical conductive composites for electromagnetic interference shielding and lightning strike protection will be investigated as well. A cradle to grave Life Cycle Assessment (LCA) will be carried out to compare the new eco-composites with the state-of-the-art materials.8 European partners will be involved in ECO-COMPASS. The duration of the project is three years.


**Keywords:** Bio-composite, bio-fibre, bio-resin, eco-composite, multi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards materials at extremes: from intense dynamic compression to expansion' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The project aims at developing robust, reliable and effective techniques for generation of extreme conditions. Positive TPa as well as negative MPa pressures in liquids will be produced with limited resources available in everyday research environment.The project offers a unique integration of approaches and resources in high voltage engineering and plasma physics applications towards classical problems of compressible fluid mechanics. It investigates by experiment, computation and theory the major physical properties of imploding shock waves in liquids and offers approaches to enhance efficiency of the focal energy concentration. The project develops a novel method for generation of imploding rarefaction waves, a well controlled scenario that provides with exactly opposite range of extreme conditions, namely negative pressures in liquids. The approaches comprise a single generator facility that opens research on a broad spectrum of basic-to-applied subjects, promising a long-term investment towards studies of materials at extremes.The facility is applied on a selected subject of mechanical treatment of cellulose fibers, aiming at enhancing the efficiency of fibres disintegration, homogenization and fibrillation processes by applying, both selectively and combined, compression and tension pulses on a broad range of intensities, from strong to extreme.


**Keywords:** Shock wave, Implosion, Rarefaction wave, Expansion, Extreme conditions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart hybrid integrated navigation equipment (SHINE)' (SHINE), addressing dissemination and exploitation.

assistant: **Impact**

Overall objective of SHINE programme is to improve air transport efficiency and quality by offering at low cost to maximum of aircraft new navigation and attitude sensors enabling to fly and land in a more dense European airspace with same or better safety .To this aim a prototype of an airborne equipment based on low cost inertial sensors emerging technology and using advanced processing techniques (inertial-GNSS sensors data fusion, GNSS attitude determination, self redundant inertial sensors, new techniques for GNSS processing in interface environment ) will be designed, manufactured and flight tested . A cost size and weight reduction factor of 2 is estimated for short term applications (2002) regional aircraft, light business Jets and heavy helicopters). Higher gain is identified for mid/month term (2006/2008) applications on commercial aircraft.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Novel cooling system for the cryogen-free, continuous, and fully-automatic generation of very low temperatures near absolute zero.'.

assistant: **Concept**

Low temperatures close to absolute zero (0 degrees Kelvin) are required for materials science, detectors for the aerospace and military sector, quantum computing, and quantum electronics. These temperatures are commonly achieved by using cryogenic liquefied gases (cryogens), such as liquid helium (He). However, there are a numbers of problems related to the use of these cryogens which include the oligopoly of He-3, high costs of cooling machines (€ 300-600k), and safety problems.To solve these pains, kiutra has developed a cryogen-free, continuous, and fully automatic refrigeration system based on a cryogenic magnetic cooling process known as Continuous Adiabatic Demagnetization Refrigeration (CADR). CADR uses widely available and low-price cooling media, saving € 20-40k/year in comparison with typical refrigeration systems that use He-3. Moreover, the system has a complete modular and customizable design, as it can be extended with multiple units according to the cooling requirements. It also offers a wide and stable temperature range while being easy to operate and hazard-free, thanks to the elimination of cryogens.kiutra, founded in 2018 in Germany, builds easy-access turn-key refrigeration solutions. Their cooling devices combine magnetic refrigeration and closed-cycle pre-cooling to provide cryogenic temperatures without cryogens. kiutra is currently funded by “EXIST Transfer of Research”, and has raised almost € 2M to date. The proposed work in Phase 1 of the SME instrument fits into their overall plan to reach market by contributing to the financial resources needed to further improve and test CADR system, and ensure market uptake.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mechanisms of α-synuclein spreading, implications for synucleinopathies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A common feature of neurodegenerative diseases, including highly prevalent illnesses, is the presence of misfolded protein aggregates in affected regions of the nervous system. Aggregates result from the misfolding of one or more specific proteins, for example, amyloid-β in Alzheimer’s disease, α-synuclein in Parkinson’s disease, and the normal prion protein in transmissible spongiform encephalopathies (TSEs). Recently a series of exciting studies has suggested a prion-like mechanism underlying the pathological spreading of misfolded proteins (mainly tau, α-synuclein and huntingtin) involved in various neurodegenerative diseases. Particularly striking is the recovery of α-synuclein aggregates from engrafted embryonic neurons in post-mortem brains transplanted from Parkinson’s patients. Thus, while questioning the therapeutic use of transplants, the understanding of the molecular and cellular fundaments of cell-to-cell transmission of proteinaceous aggregates is clearly in the early stages of investigation and may represent a more readily accessible target for novel disease-modifying therapies, allowing the development of possible common therapeutic strategies. Tunneling nanotubes (TNTs) represent a novel mechanism of direct intercellular communication that has been shown to mediate both transfer of prions between neuronal cells and the passage of poliQ huntingtin between neurons. We hypothesize that TNT-mediated transfer of amyloidogenic protein aggregates represents one of the main pathways of communication between cells. Thus, molecules involved in TNT formation could represent valuable targets for the disease prevention. Here I will assess the underlying mechanism of cell-to cell transfer of α-synuclein, exploring whether its transport could be mediated by TNTs in ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards outstanding research and training in tumour biology at IMM' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cancer is a major societal health issue in Europe. In 2012, cancer accounted for around 1.3 million deaths and an estimated economic impact of around € 126 billion in the European Union (EU).The Instituto de Medicina Molecular (IMM) aims to fight this destructive disease by reinforcing its capacity for outstanding pre-clinical and translation research, and by creating a dynamic cluster of excellence within the Lisbon region in the field of cancer research. Towards this goal, IMM is building up a network for outstanding research and innovation with two leading research institutes, the Institut Curie (the largest European cancer research centre), and the DFKZ - Deutsches Krebsforschungszentrum (the largest cancer research institute in Germany), the ReTuBi consortium. ReTuBi targets 4 specific scientific areas: Cancer Stem Cells; Cancer Signalling; Cancer Invasion and Metastasis; and Tumour Angiogenesis. ReTuBi is designed to stimulate the establishment of novel and long-lasting interactions between groups at IMM, Institut Curie and DFKZ. The dynamic and intensive research framework is focused on promoting the exchange of know-how in research excellence and cutting-edge technologies to tackle current and future challenges in tumour biology. Through this initiative, ReTuBi expects an increase of 30% in multiple indicators until 2020, including the number of citations per publication; h-index of IMM researchers; percentage of publications in top 10% impact journals; number of filed patents; and number of international collaborative projects. ReTuBi will also have an impact in the entire IMM community and Lisbon area, through organisation of open scientific meetings, summer schools, and workshops.ReTuBi extensive dynamic network of interactions will provide a channel of knowl