RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Leaving home, living arrangements and living situations of the young adults in Western Europe. Employment, family and housing histories'.

assistant: **Innovation**

As an extension of my doctoral thesis and in line with a way of thinkin which stresses the importance of the flow approach to labour markets, I propose a research agenda that can be summarized into three points: description of the data, modelling, and forcasting and simulation.  1) As a first step, it is necessary to glance at the data. My intention is to use longitudinal information given at microeconomic level by survey data and at macroeconomic level by data on vacancies and other relevant variables.  This information will be used to give a description of the gross flows which will be considered in the analysis. Also, another point of interest will consist on estimating those flows by industries, occupations and professional status, obtaining interesting information about the source and the destination of individuals. And, finally, I will try to find out a series of 'stylized facts' related to the gross flows behaviour in the business cycle (and find out their consistency with macroeconomic and labour market theories).  2) The second part of the research agenda deals with the development of model based on the gross flows of workers and jobs. This model aims at building behavioural equations for each flow between different labour market states and for jobs (vacancies). Special attention will be given to the formalisation of job creation (the matching function) and job destruction processes, and of the wage formation. These issues are considered of great importance, as they are the key issues for the functioning of the model. Therefore, different alternatives should be discussed in order to adequate the model to reality.  Also, the basic structure of the model can be extended to discuss more specific hypothesis about the functioning of labour markets.  3) The third par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The co-operation of subunits in polyketide synthases' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Truncated versions of the erythromycin-producing polyketide synthase (PKS) will be engineered, in which specific active sites are mutated. The pattern of intersubunit protein-protein interaction in these giant multienzymes will be deduced by studying heterodimers of such mutants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Palaeolithic ungulate hunting strategies in the eastern Iberian Peninsula through advanced proteomic profiling'.

assistant: **Concept**

Recent zooarchaeological analyses have suggested that Neanderthals were skilled hunters. Yet, there is still a vivid debate on whether Middle Palaeolithic human groups were also capable of more effective, and diverse, sophisticated food-processing behaviours, in particular through specialised hunting. Traditionally, archaeologists have relied on the osteological analysis of bone assemblages to determine prey mortality patterns, where species variability, age and seasonality data are calculated. Although this approach has yielded a great deal of important information about the Pleistocene hominin hunting strategies, there is a considerable lack of sex-based prey data for most Pleistocene bone assemblages, a key information that has direct implications for hominin planning depth, anticipatory abilities, mobility and land use. IBERHUNT project will conduct advanced biomolecular analyses in ungulate dental assemblages and sediments from six rich-faunal Middle and Upper Palaeolithic sites in the eastern Iberian Peninsula. The anthropic occupation deposits range Marine Isotope Stages (MIS) 5 to 3, making them exemplary case studies for comparative-based research. We aim to address 1) the determination of the biological sex of ungulate remains, by reading protein sequences through the analysis of tooth enamel amelogenin, and 2) the identification of palaeoenvironmental biomarkers, by the analysis of sediments’ compound-specific isotope ratios. This combination of state of the art techniques will provide contextualised and quantifiable high-resolution data on Pleistocene human foraging efficiency, allowing to re-evaluate Neanderthal predatory economics through an optimal foraging perspective that includes climate adaptations.IBERHUNT results will bring the discussion of evoluti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Pinpointing novel molecular and cellular functions generated by retroelement onco-exaptation' (RETROFIT), addressing dissemination and exploitation.

assistant: **Impact**

Exaptation, the co-option of endogenous retroelements (EREs) for new molecular and cellular functions that confer a host fitness advantage, is a major force in evolution, but may also be exploited, through onco-exaptation, by tumour cells to promote the oncogenic process. There are over 4 million well-recognised and annotated individual ERE integrations in the human genome. However, their participation at the level of the more complex transcriptome is far less well understood and, therefore, the number of onco-exaptation events is likely vastly underestimated. To allow detection and quantitation of ERE transcription, we have recently de novo assembled the cancer transcriptome. This resulted in a doubling of the known transcriptome, particularly of unannotated or partially annotated transcripts derived from or overlapping with EREs. Here, we propose to utilise this extended view of ERE transcription as the framework for:•building a genome-wide map of functionally validated ERE onco-exaptation events and •pinpointing novel, targetable functions of EREs in immunity, cancer and their intersectionAlthough we identified thousands of novel ERE-overlapping transcripts in cancer, the majority are likely the consequence of transcriptional activation of normally silent EREs, with little or no impact on host cell function. Impactful and inconsequential ERE integrations will be distinguished based on a number of features, including association with cancer overall survival or response to immunotherapy, impact on adjacent gene function, evolutionary conservation and functional domain and folding predictions. Postulated function will ultimately be tested extensively in in vitro cancer cell lines, ex vivo cancer patient material and in vivo mouse cancer models, tailored to the relevant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ROLE OF THE TRANSCRIPTION FACTOR FOXP1 IN B CELL FUNCTION AND LYMPHOMAGENESIS' under Seventh Framework.

assistant: **Concept**

FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that has been demonstrated to be expressed in a subset of activated B-cell type (ABC) diffuse B-cell lymphomas (DLBCLs). Strong FOXP1 expression appears to have an additive adverse role in the pathogenesis and clinical behavior of ABC-DLBCL. We believe that a better understanding of the molecular impact of FOXP1 deregulation in DLBCL will help us to improve the correct stratification of cancer patients as a prerequisite for acute diagnosis, and will allow us to propose novel pre-clinical therapeutic strategies to target the FOXP1-axis. To achieve this, we propose to characterize a collection of primary human DLBCL samples, stablished cell lines and the novel Emu-FOXP1 transgenic mouse model that has been recently generated in our lab, in an attempt to identify deregulated B-cell functional pathways, as well as sets of genetic and epigenetic events that might be ""passengers"" and/or ""drivers"" of lymphomagenesis. Our preliminary data has identified the B-cell mutagenic enzyme AID (activation-induced deaminase) as a FOXP1-target gene that could promote genetic and epigenetic instability in germinal-center B-cells. Consequently, we propose to explore the functional interaction of FOXP1 and AID both during normal B-cell activation and malignant B-cell transformation. By exploring functional and therapeutic strategies of targeting potential FOXP1/AID-related targets we pursue the development of translational protocols that could be used in the clinic to better diagnose patients with DLBCL and set the basis for designing future treatments and clinical trials.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'History Books in the Anglo-Norman World c.1100-c.1300' (2007-2013).

assistant: **Innovation**

This project will examine surviving medieval manuscripts in order to investigate the writing of history in areas controlled by the Anglo-Norman Empire in the twelfth and thirteenth centuries.  In this period, history (referring to both the recent past and stretching back to biblical chronology), seems to have become a major interest for both the educated elite and a growing semi-literate population.  New chronicles and annals were produced, together with accounts of the histories of particular peoples, nations and subjects.  Much historical writing in this period dealt with issues of conquest and identity, which was often allied to geography, ethnicity or particular institutions.  In addition to the very well-known Anglo-Saxon Chronicle in its many versions, some twelfth-century writers achieved recognition for their work on historical topics.  In the thirteenth century their work, together with that of earlier writers, most notably Bede, was taken up and developed by writers such as Matthew Paris, and many monastic chroniclers.  At the same time some of this material began to be illustrated, both with figurative imagery and with technical diagrams.  This project will investigate the surviving volumes in which such works are contained.  It will address their size and layout, the materials used in their production, and in particular their decoration, to consider the circumstances in which they were produced and circulated, the audiences for the material, and attitudes to both particular ideas and stories, and to historical writing in general.  In particular it will consider how images, and the manuscripts in which they appeared, were used to express particular ideas about the diverse communities encompassed by the Anglo-Norman Empire as its boundaries expanded in the twe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A method to integrate scientific and clinical knowledge to achieve the appropriate utilisation of major medical and surgical procedures' under Fourth Framework.

assistant: **Concept**

- To link ongoing European research employing the RAND appropriateness method (RAM) in a way that co-ordinates methodological development.- To increase the degree to which countries benefit from each others' and joint use of the RAM.- To improve the delivery of health care by health care managers' understanding and use of health services research. These three global objectives translate into a set of measurable objectives:Faced with a need to determine the criteria for the appropriate use of procedures, health services researchers in a number of European countries have been turning to a method that can provide policy makers information about the nature and extent of both overuse and underuse of frequent and/or expensive medical and surgical procedures. The centrepoint of this method is a modified Delphi expert panel whose inputs are a thorough review of the scientific literature and the clinical judgement of experienced and respected practitioners and whose output is a rating of the appropriateness and necessity of the procedure for every member of a comprehensive list of its indications. These ratings are then set against data regarding actual usage to determine the appropriateness if the procedure's use.The experience of the researchers has brought awareness of a need to modify the method, in order to improve its reliability, consistency, and ease of use. The reinforced concerted action proposed here will link the principal European users of the method, in order to co-ordinate the needed methodological improvements. While each research centre will study topics dictated by national priorities (subsidiarity), the methodological advancement will be of a scope, rate, and quality that could not otherwise be achieved (community added value). This will yield benefits in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Neutrons for Membrane Protein Structure, Interactions, and Assembly' in the context of a Seventh Framework call.

assistant: **Objectives**

Understanding membrane protein structure, interaction between these proteins and lipids, and how membrane proteins assemble in the membrane are as of yet unsolved problems of structural biology. This proposal aims to further our understanding in these areas by uniquely combining structural and biophysical data obtained from nuclear magnetic resonance experiments (Straus` area of expertise) with neutron methods, such as small angle neutron scattering (SANS), reflectometry, and neutron diffraction (Forsyth`s and other ILL members` area of research). Specifically, the team will focus their attention on three areas: 1) membrane perturbing antibiotic structure; 2) interaction of lipopeptides with the essential bacterial cell wall biosynthesis component lipid II; and 3) the assembly of membrane proteins in lipids, as studied using the tractable system of B5 filamentous bacteriophage. The proposed projects will not only enable Straus to expand her repertoire in structural methods by exposing her to a host of neutron methodology, but will also cement a strong partnership between Canada and France. The projects will also involve the close collaboration of a number of research groups in France and Germany: the group of Michel Gauthier in Nantes, a leading expert in B5 filamentous bacteriophage and the group of Hans-Georg Sahl in Bonn, who have worked extensively on characterizing interactions between lipopeptides and lipid II. The interdisciplinary nature of the proposed work and the strength of the team will ensure success on all fronts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Organic Bioelectronics' (ORGBIO) targeting Seventh Framework.

assistant: **Abstract**

Organic Bioelectonics is a new discipline which holds promise to shape, direct, and change future medical treatments in a revolutionary manner over the next decades. At the moment Europe has a unique leading position in this area, being almost all the world-leading groups in this field located in Europe and constituting the core of this international training network. However, realizing the promise of “Organic bioelectronics” requires research and training not only crossing disciplines, such as electrical engineering, biology, chemistry, physics, and materials science, but also crossing our European countries.“The EU will add value on the global scene only if it acts jointly”.OrgBIO is at the core of European technological innovation and will become an indispensable part of the educational canon. It will establish a world-class training platform spreading around the highly interdisciplinary / intersectorial European-led area of organic bioelectronics.Education along with science and entrepreneurial mindsets and attitudes is the core of the OrgBIO training programme, which aims at excellence and innovation, at all level. Excellence in science is guaranteed by the world-leading groups which founded this research area.Innovation in education is guaranteed by the involvement of researchers on education, business experts.Using different sensors, actuators, electronic and interconnect technologies the network will develop multifunctional systems based on organic devices and materials with high sensitivity that are also flexible, conformable and present over large areas for various biomedical / biological applications in the life science. Multi-analyte and disposable analytical systems manufactured by large-area printing methods will provide services to the individuals and hea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanisms of gradient decoding in fission yeast'.

assistant: **Innovation**

How does a cell orient in response to a chemical cue? This basic problem is at the core of how cells interact with their environment. Indeed, the ability to move towards the source of a chemical gradient underlies behaviours as diverse as feeding, identifying a foreign invader or building interconnected cellular networks. Furthermore, chemo-orientation forms the basis of gamete recognition, and is thus critical for genome diversification through sexual reproduction. This proposal makes use of one of the simplest eukaryotic models, the fission yeast S.  pombe, to systematically dissect the mechanisms of gradient detection. Gradient sensing occurs during sexual reproduction in a speed-dating process for mate pairing, where dynamic cortical polarity patches secrete pheromones and become stabilized in response to those produced by the other mating type. Chemo-detection depends on a minimal kit of conserved eukaryotic proteins, suggesting that a complete understanding of gradient decoding is possible. We will work towards this goal through four specific aims:1.to establish the rules of gradient decoding, using unbiased image analysis and caged pheromones;2.to define the architecture of the communication site, by super-resolution and correlative light-electron microscopy;3.to probe the molecular regulation of cellular speed-dating, which we hypothesize consists of a spatial decoder and dynamic oscillator;4.to reveal natural modifiers of speed-dating for mate selection, by exploiting the diversity of wild strain isolates.By combining advanced live and correlative imaging with optogenetic, genetic, biochemical and genomic methods, this project will bring a conceptual and molecular understanding to the problem of gradient decoding. Due to the ancient and fundamental nature of gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Phase-locking of terahertz quantum  cascade lasers' (TeraPhase) under Seventh Framework.

assistant: **Objectives**

The terahertz (THz) region of the electromagnetic spectrum, between the infrared and microwave range, has historically suffered from a lack of sources and detectors, leading to the phrase ‘terahertz gap’ to be coined. In recent years however there have been a number of sources and detectors developed in this region. Two of these new technologies are THz time-domain spectroscopy (TDS) and THz quantum cascade lasers (QCL).In this project we seek to combine these technologies and phase-lock the THz QCL in the time domain to a TDS system. This will allow the temporal resolution and coherent detection of the electric field output of the QCL and will permit investigations into the fundamental laser processes of the ultra-fast gain build-up, saturation and recovery times over time-scales of pico-seconds. The first stage of the project will demonstrate the effect of phase locking by injection of a THz pulse into the QCL and forcing the latter to show laser action at a known phase. In the latter stages of the project, the process of phase locking will be used to unambiguously demonstrate mode-locking and the generation of THz pulses from a QCL in the time domain. As well as directly measuring the electric field dynamics of a mode-locked laser, the essential parameters governing mode-locking such as gain lifetimes will be investigated.Finally, as well as insights into fundamental physics of ultra-fast laser field build-up, this project will have several technological benefits. The resulting system will produce short, high-power, phase-resolved pulses of THz radiation that are currently only available at large scale facilities. These generated ultra-fast pulses can be designed in terms of duration, tunability and bandwidth using the unique QCL property of bandstructure engineering