RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Skin micro-injector' (BoldJet) targeting Horizon Europe.

assistant: **Abstract**

Needle-based injections are very common in modern medicine, notably in ongoing vaccination efforts worldwide. However, needle phobia and infection risks affect patient compliance with medical treatments, while millions of used needles contaminate the environment. Lastly, the effectiveness of certain drugs increases when injected intradermally, but targeting the dermis is challenging. Thus, new minimal-invasive procedures are needed. Jet injectors are needle-free medical devices that pressurize thin liquid filaments to penetrate the skin. Jet injections have been effective in subcutaneous and intramuscular delivery, ex vivo, and in vivo. However, the expected needle-free revolution for medical treatments has neither been fulfilled, nor widely commercialized due to factors such as: a) Bruising, a painful consequence of delivering large volumes in a single location. b) When using wrong energy settings, or misalignment with respect to the skin, the injected liquid can perfuse other layers. c) The rejected liquid splashes back, leading to an incorrect dose delivery, risks of cross contamination of the injector parts, or splash-back on the care giver. d) Commercial jet injection methods, such as springs or compressed gas, are noisy which can distress the patient. Hence, there is a need to develop a new way to deliver smaller doses with maximum accuracy in targeting specific skin layers. Bold-Jet is aimed at revolutionizing the experience of people who receive or perform frequent injections by developing for the first time a needle-free device using microjets that is safer, minimally invasive, and eco-friendly. By avoiding the use of needles, we can increase adherence to treatments by patients with fear to sharps and expand clinical routes for existing drugs and treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Studies of Quantum-Gravitational Relativity Violations' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The largest gap in our understanding of nature at the elementary level is arguably a unified quantum theory of all fundamental forces including gravity. Despite substantial theoretical efforts, observable effects are either unknown or expected to lie below the sensitivity of most experiments. However, violations of Einstein's Relativity have recently been identified as promising experimental quantum-gravity signals. Discovery potential for these signals exists in certain observations associated with cosmic rays, varying couplings, and neutrino oscillations. The modern Standard-Model Extension (SME) has become the standard framework for the identification and interpretation of experimental Relativity tests (e.g., PARCS, RACE, and SUMO on the International Space Station). At present, expertise in theoretical SME research lies undoubtedly in the US.The principal objective of the present project is the integration of this emerging research field into European science through a well-balanced combination of theoretical and phenomenological SME investigations. The purely theoretical analyses are aimed at gaining a deeper insight into Relativity-violating mechanisms and at providing the massless sectors of the SME with a more solid foundation. The expected phenomenological consequences of these studies will be addressed in a subsequent part of this project. They are likely to be of importance for neutrino oscillations, for the investigation of astrophysical effects, and the analysis of certain Relativity tests (e.g., European space-based experiments, such as ACES scheduled for the International Space Station and the German OPTIS proposal). This timely cutting-edge Relativity research has the potential to unlock some of the most fundamental secrets of our Universe during the Ein
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Research on Materials Ageing and Structural Integrity of Research Reactors' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Many of the existing Research Reactors (RR) in Europe are very old (>60 years operation). Only few initiatives are taken (PALLAS and JHR) to partially replace this capacity. Continued operation of these RRs is mandatory (at least until the new reactors come to operation) to maintain the EU excellence in development and qualification of nuclear materials for advanced reactor concepts and to maintain the supply of medical isotopes. License extensions for continued safe operation (CSO) requires ageing management review (AMR) and time limited ageing analysis (TLAA) of critical structures and components. However, there is limited understanding of damage mechanisms and lack of materials data on RR materials at relevant operating conditions for long term operation of RRs. In addition, there is a shortage of surveillance specimens for extending the operational life for some RRs. Lastly, sharing of knowledge and operational experience is crucial in this relatively small RR community.Magic-RR addresses aforementioned issues by leveraging (1) available archive materials and data from the existing research reactors, e.g. from surveillance programs and shut down reactors, (2) operational experience of research reactor operators and (3) advanced characterization and modelling techniques at universities and nuclear research centers. To achieve this goal Magic-RR focuses on the following topics in order to CSO of European RRs:•Improved understanding on irradiation induced damage in RR structural materials (specifically Al alloys) at high fluence conditions•Application of advanced multi-scale modelling methods for prediction of irradiation influence on mechanical properties •       Investigation of corrosion mechanisms and its prevention/mitigation•Assessment of sub-size testing for sur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development and automation of a method to select and produce phage-display antibodies to peptides' in the context of a Fourth Framework call.

assistant: **Objectives**

The Human Genome Project recently has produced nearly a million different Expre ssed Sequence Ta (ESTs) for which often no functional proteins are known. To us e this information there is an urgent need frc industry as well as from non pro fit organisations, for new technologies to link the DNA information to t functi onal protein expression. It is attractive to use protein fragments or peptides encoded by these sequence and in particular antibodies to these products, to st udy the expression and biological activity of the products. However, the curren t technologies to make anti peptide antibodies involve animals, are time a, mon ey consuming and, since for each peptide antibody one or several animals are ne eded, are not suited large scale automation. Recently a new technology, antibod y phage display, was developed, that makes possible to select and produce antib odies completely in vitro. The method is now generally used to deri antigen spe cific antibodies, provided pure antigen is availabe; this had not extensively b een applied peptides yet. It is with this phage display method that we would li ke to address the issue of generati thousands of anti peptide antibodies. O bjectives This project aims to combine the use of peptides as antigens and t he use of very large phage antibody librari to derive fast, in an automated fas hion, peptide specific antibodies, which may than be used f biotechnological or medical research, for diagnostic applications and as starting material for imm unotherapeutics. We will use a universal, naïve human Fab library containing ov er 10'° different antibody fragments and made by partner A2 in our studies. The first goal is to find the optimal conditions forcoating and presentation of th e pep tides to the antibody library. Next, the new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Loop Corrections from the Theory of Motives' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The interactions between the elementary particles are encoded into a set of mathematical quantities called scattering amplitudes. Consequently, they are key to making predictions for physical observables that match the precision achieved by current and future high-energy experiments. Due to our ignore of the mathematics involved, computing loop quantum corrections to scattering amplitudes is still a major challenge today, and calls for innovative and groundbreaking new techniques.Over the last decade, a new field of research that studies scattering amplitudes through the lens of a certain branch of modern mathematics, the so-called theory of motives, has led to breakthroughs in how we compute loop quantum corrections. LoCoMotive will bring the connection between scattering amplitudes and modern mathematics to the next level. It will investigate in detail what the theory of motives teaches us about the structure of scattering amplitudes. Its final aim is to achieve a global change of perspective on the mathematical underpinnings of the laws of nature and develop novel computational techniques for scattering amplitudes that are currently beyond reach of conventional state-of-the-art technology. Inspired by cutting-edge research in seemingly-disconnected areas in mathematics and physics, LoCoMotive will 1) perform the computations needed to reveal how concepts from geometry govern the fundamental interactions.2) play a decisive role in providing the theoretical predictions needed for the LHC and future collider experiments. 3) act as a catalyser for new research in mathematics.To sum up, LoCoMotive is a timely proposal with a unique multi-disciplinary character, whose results will bridge a gap between formal theory and concrete phenomenological results. It will have a majo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'cmos-compatible nonlinear integrated Mid-IR frequency COMBs', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

MIRCOMB for « nonlinear integrated Mid-IR frequency COMB » is aiming at creating novel integrated nonlinear sources on CMOS for applications in the mid infrared (mid-IR, wavelength range between 2 and 10 um). The mid-IR wavelength domain is of great interest for a huge range of applications that affect almost every aspects of our society, from highly sensitive biological and chemical sensors, homeland security applications, industrial and environmental monitoring, defence, astronomy... The reason is that most chemical and biological compounds have unique fingerprints in this range that can be exploited in detection schemes with unprecedented reliability, sensitivity and precision. The surge in interest in the mid-IR has been recently driven by breakthroughs in novel sources in this wavelength range. QCLs generating light between 4 μm and 250 μm are commercially available but remain extremely bulky. The availability of integrated components for the mid-infrared remains actually extremely limited. Devices operating in the mid-IR are largely restricted to stand-alone and narrow-band sources and simple passive optical light guiding, typically based on highly multimoded fiber in chalcogenide glass, silver halide fibers, and hollow core fibers. However, over the past three years, there have been calls for the migration of techniques developed by the near-IR community to the mid-IR. In particular, Soref and Jalali have pointed out that group IV materials like silicon and Ge are ideal candidates for applications far beyond the window of telecom applications – right up to 5 μm and 10 μm respectively. This project addresses this vision and will benefit many sectors and priority areas listed by this P2N call. More specifically MIRCOMB will target highly innovative i) supercontinuu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cortical visual neuroprosthesis for the blind' to be submitted under Fifth Framework.

assistant: **Abstract**

This project aims to develop prototypes in the field of visual rehabilitation and to demonstrate the feasibility of a cortical neuroprosthesis, interfaced with the visual cortex, as a means through which a limited but useful visual sense may be restored to profoundly blind people. The results from this project will provide information regarding neuroprosthesis not presently available, as well as new information about the plastic changes in the adult nervous system, which has implications for rehabilitative training and device development. Although we are still a long way from a perfect visual prosthesis, the success of the cochlear implant seems very promising also for this neurotechnological application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Drying river networks – Understanding and mitigating drought impacts on river ecosystem functioning and biodiversity (MetaDryNet)' (MetaDryNet) targeting Horizon 2020.

assistant: **Abstract**

One of the greatest challenges of the 21st century is to understand and mitigate the effects of climate change on earth ecosystems. Climate change increases the frequency and intensity of hydrological droughts worldwide. In rivers, drying (i.e. the loss of surface water) is a severe disturbance that alters biodiversity and ecosystem functions such as organic matter (OM) decomposition with often negative consequences for ecosystem services (e.g. water purification) and human activities (e.g. water consumption). River networks are an aquatic continuum in a terrestrial matrix in which OM is transported, and organisms disperse laterally: from terrestrial to aquatic environment, vertically: from the riverbed surface to the subsurface and longitudinally: along the network. Drying, modifies OM transport and dispersal by cutting the water continuum, potentially altering an entire river network´s OM decomposition dynamics, and hence carbon cycling and CO2 emissions. Although, much is known about the effect of drying at local scales, very little is known about its effects at the entire river network scale. Only studies done at an appropriate large scale can adequately inform and help to develop an adaptive management that minimizes drying impacts on river ecosystems and human activities. By combining meta-analysis, network-scale field experiments and modelling, MetaDryNet will explore the effects of drying on OM transport and decomposer organism dispersal to determine how drying affects OM decomposition and CO2 emissions in river networks. Using new technologies, novel ecological theories and complex modelling approaches this research is highly innovative and will allow to improve our understanding of how resources and biodiversity are linked in space and time in drying river net
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantifying Weather and Climate Impacts on Health in Developing Countries' (QWECI).

assistant: **Concept**

One of the most dramatic and immediate impacts of climate variation is that on disease, especially the vector-borne diseases that disproportionally affect the poorest people in Africa. Although we can clearly see that, for example, an El Nino event triggers Rift Valley Fever epidemics, we remain poor at understanding why particular areas are vulnerable and how this will change in coming decades, since climate change is likely to cause entirely new global disease distributions. This applies to most vector borne disease. At the same time, we do not know currently the limit of predictability of the specific climate drivers for vector-borne disease using state-of-the-art seasonal forecast models, and how best to use these to produce skilful infection-rate predictions on seasonal timescales. The QWeCI project thus aims to understand at a more fundamental level the climate drivers of the vector-borne diseases of malaria, Rift Valley Fever, and certain tick-borne diseases, which all have major human and livestock health and economic implications in Africa, in order to assist with their short-term management and make projections of their future likely impacts. QWeCI will develop and test the methods and technology required for an integrated decision support framework for health impacts of climate and weather. Uniquely, QWeCl will bring together the best in world integrated weather/climate forecasting systems with heath impacts modelling and climate change research groups in order to build an end-to-end seamless integration of climate and weather information for the quantification and prediction of climate and weather on health impacts in Africa.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Flexible robotic solutions for the recycling of soft materials' (FlexCycle).

assistant: **Concept**

Improved circular economy relies strongly on improved methods for recycling where automation begins to be an important factor. FlexCycle addresses the domain of soft material recycling. Here automation is largely lacking, because these materials are elastic, hard to handle, and – being “trash” – are often found in unpredictable states of degradation. This makes flexible, adaptive solutions for automation an absolute necessity. This requirement is amplified by the fact that soft materials exist in many consumer products. However, specialized recycling solutions for one product group (e.g., cloth) are usually inalterable and inflexible and cannot be used elsewhere (e.g., for cables). FlexCycle addresses this difficult problem and our main contribution is to develop flexible automation methods that allow for fast and efficient transfer between different domains of soft material recycling. We address three, structurally quite different, use cases: cloth, cables and membranes from fuel cells. The novel concept of across-domain transfer of recycling methods will be achieved by adaptive components in (1) hardware and (2) software: 1) We are developing new kinds of soft, under-actuated end-effectors and other flexible robotic tools, allowing us to handle different materials with minimal hardware-reconfiguration. 2) We are developing a generalized, novel framework for modeling soft material handling by combining a substrate-overarching structural model of soft materials with advanced graph-attention neural networks to infer the desired robotic action(s). The main impact of FlexCycle is, thus, a domain independent automation approach for recycling and reuse of soft materials allowing for reduction in system setup- and programming effort based on these novel models and hardware el
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Improving Digital Mental Health Interventions: ENGAGEment as Mechanism of Impact'.

assistant: **Innovation**

Millions of people struggle with mental health issues, such as depression and anxiety. Effective treatments exist but are not within reach of everyone due to limited resources. Digital Mental Health Interventions (DMHIs), in which treatments are delivered by using technology via the Internet and apps, can be a solution. However, high rates of drop-out and large individual differences in outcomes make them not yet an adequate solution. Due to scarce process research, with  a largely mono-disciplinary focus and reliance on group-level studies, we have limited insight into how to match DMHI components to individuals.In ENGAGE, I tackle these issues by proposing that engagement is the mechanism of impact that provides the missing link between the intervention components and individual outcomes. Earlier research has shown that engagement is a multidimensional and interdisciplinary concept consisting of behaviour, cognition, and affect. I have developed a first scale to measure engagement, shown individual differences and have shown individual engagement is predictive of outcomes. However, the developed scale is a rudimentary way of measuring engagement using self-report at fixed time-points and as a one-dimensional construct. Consequently, we have only a basic understanding of engagement which does not do justice to its complex multidimensional nature.ENGAGE will yield the following insights and outcomes:A fine-grained understanding and measurement of real-time engagement, showing the relationship between the dimensions, both on an individual level and over time.Expanding the toolbox of intervention designers to directly influence the individual mechanism of impact, by identifying and analysing the effect of strategies which influence individual engagement with DMHIs.Verific