RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identifying cellular and molecular features of protective anti-malaria B cell response' (Bmem-Malaria) under Horizon Europe.

assistant: **Objectives**

Malaria is one of the leading life-threatening diseases with a reported 627,000 deaths and 241 million infections in 2020, mostly in low-income countries. Despite the advances gained by control measures, malaria incidence by Plasmodium falciparum (Pf) has plateaued in the last decade. Intervention through vaccines and antibody therapy shows promising results, yet long-lasting protective immunity remains unattainable. Anti-malaria memory B cells comprise transcriptionally distinct sub-populations, but their contribution to protective immunity is unclear. Here, I plan to combine state-of-the-art strategies to identify the cellular and molecular features of protective immunity offered by B cells and encoded antibodies, respectively. To that end, I will use the unique samples from controlled human malaria infection trials to isolate memory B cells reactive to Pf antigens, obtain transcriptome and immunoglobulin (Ig) gene sequences at the single cell level and measure antibody inhibitory properties at the monoclonal level. Transcripts signifying resting, activated or exhausted phenotype will allow memory B cell clustering, whereas Ig gene features will help define clonal expansion and selection strength of antibodies. By cloning and testing antibodies in specialized in vitro and in vivo assays, I aim to discover potent inhibitory antibodies targeting different parasite developmental stages. I will reveal the protective antibody molecular properties defined by Ig gene features, affinity, and epitope specificity. By single-cell level integration of transcriptome and antibody functionality for the first time, this project will not only deliver potent parasite inhibitory antibodies of therapeutic potential but also lay a clear blueprint for attaining protective immunity through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated MNT platforms and services - service action' under Sixth Framework.

assistant: **Concept**

The overall aim of this Service Action Integrated Project is to provide access services and prototyping platforms with a route to manufacture for highly integrated microsystems, combining smart silicon functionality with polymer in a multi-domain environment. This will be achieved by extending the Europractice manufacturing Cluster INTEGRAM, which focused on Silicon sensors and electronics, to multi-technologies (Silicon, polymers) and multi-domains (fluidic, optical, mechanical, electrical, biological).The consortium will also pull through and exploit for customers Design for Manufacturing principles being developed in the FP6 Network of Excellence PATENT-DfMM. This new multi-polar centre, INTEGRAMplus, will be a unique combination of competences across Europe linked with a network of supply chain partners and aims to provide European industry with a world-leading facility to stimulate take-up and accelerate time-to-market of smart mixed-technology components and solutions.The goal is to achieve a high degree of flexibility to address the need for increased complexity in microsystems without sacrificing the requirement for stable manufacturable processes. This will be achieved by focusing on standard processes and interfaces with design rules but offering additional functionality through incorporation of non-standard materials and linking multiple technologies. The focus will be on integrating Silicon-based MEMS components, which provide smart functionality, with polymer backplanes and platforms which provide additional functions, packaging and interfacing to the macro-world.The combination of the complementary capabilities of the partners and the ability to design, prototype and manufacture via a distributed network will demonstrate a new flexible manufacturing method
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biogenic Organic Crystals: From Crystal Formation to Genetically Engineered Optical Materials' (CRYSTALEYES), addressing dissemination and exploitation.

assistant: **Impact**

Many spectacular optical phenomena in nature are produced by the interaction of light with organic crystals. Organisms exert exquisite control over the habit and organization of these crystals to determine the type of optical effect produced by using strategies beyond the state of the art in solid state chemistry. Despite their important role in animal behavior and their huge potential to inspire new optical materials, little is known about these materials. However, recent discoveries of previously unknown organic bio-crystals indicate that many more of these materials will be found and that ‘organic bio-crystallization’ is an emergent field with important implications for materials science. My overall objective is to uncover the strategies organisms use to control the formation of organic crystals, enabling these strategies to be harnessed to develop new crystalline organic materials. A pioneering approach is proposed which entails following the crystallization pathways of organic molecules in model photonic systems undergoing development. The crystallization of guanine and isoxanthopterin will be investigated to reveal the physio-chemical and biological processes underpinning crystallization. Cryogenic electron microscopy, spectroscopy and in situ diffraction methods will determine changes in the chemical and physical properties of the crystals during crystallization. Proteomic and transcriptomic studies will identify the macromolecules responsible for controlling nucleation and growth and the genes encoding them. These bio-crystallization processes will then be artificially mimicked and manipulated to produce guanine and isoxanthopterin crystals with rationally designed crystal properties (crystal habit, composition, size), including an ambitious attempt to genetical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ARGOS Conceptual Design Study: Designing a next-generation radio facility for multi-messenger astronomy' (ARGOS-CDS), addressing dissemination and exploitation.

assistant: **Impact**

Astronomy is being transformed by surveys performed with instruments capable of searching the sky multi-messenger signals with high speed and sensitivity, while delivering science-read datasets to the community. While radio astronomy is not yet fully participating in this revolution, it is clear that an instrument following the same philosophy, that would finally open up the dynamic radio sky for exploration, is not only urgent but inevitable.  ARGOS is a concept (TRL2) for a leading-edge, low-cost, sustainable European astronomical facility that will finally realize this ambition, directly addressing multiple fundamental scientific questions, from the nature of dark matter and dark energy to the origin of fast radio bursts and the properties of extreme gravity. ARGOS will enable, for the first time, continuous wide-field monitoring of the sky at centimetre wavelengths, while publicly distributing science-ready data and alerts in real time. To make the strategic scientific need for such a facility clear and accessible to funding and policy bodies, a detailed design study is necessary. This should include technical studies, community groundwork and prototyping, as well as quantitative cost-to-benefit analysis, well-calibrated project budget, and assessments of scientific and socioeconomic impact, sustainability, technological readiness and innovation needs. The ARGOS-CDS vision is to deliver a conceptual design study to fully prepare the subsequent rapid implementation of a leading-edge public radio facility on European grounds and ensure its optimal integration into the network of existing and future international astronomical facilities. ARGOS-CDS will achieve this by directly addressing the aforementioned challenges via an integrated systems-engineering approach. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A two year exchange programme on ANAerobic MIXed cultures to study and improve biological generation of chemicals and energy carriers  from organic residues generated by agro-industrial activities' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The main objective of the ANAMIX project is to build a two year exchange programme among three of the leading worldwide research groups centered around ANAerobic MIXed cultures. More specifically, ANAMIX is dedicated to study and improve biological generation of chemicals and energy carriers from organic residues generated by agro-industrial activities.  Effective leveraging of organic residues derived from human activity will be of vital importance for establishment of a sustainable society. More than 60% of all organic material obtained from agriculture is currently not made available for the production of chemicals or the generation of energy carriers. These residues generated include highly complex waste streams like pig manure, as well as more readily degradable mixtures of substrates like molasses, vinasses, and wastewaters generated during food processing. For processing of these streams, (genetically modified) pure culture based industrial biotechnology is generally not a prosperous route. The processes we intend to investigate in this project can overcome these limitations because they are based on natural ecosystems. The basic principle of these Anaerobic Mixed culture based processes is the establishment of the proper process conditions to direct the flow of electrons in a complex network of microorganisms to the product required. Anaerobic fermentative systems are ideal, as they allow for minimization of biomass that can be regarded as an unwanted side product in these processes. Valuable and realistic products are molecular hydrogen, methane rich biogas, solvents like ethanol and butanol, or the direct generation of electricity in so called microbial fuel cells. Many of these can be directly utilized in end-use applications, without further energy input.  T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Introducing a testing method'.

assistant: **Innovation**

Most GUI development tools support an incremental life cycle. As subsequent versions of a system are released, testing and maintenance become the most effort demanding issues. The cause for this is that working components of the system have to be re-tested when new modules are released or when other components are changed. This calls for automated regression testing and in general for a more profoundly understood testing method and supporting tools. This testing method should also integrate a defect tracking mechanism, guaranteeing that discovered bugs are managed efficiently and ultimately get solved.This PIE is aimed at introducing such a testing method in development process. This concern will gain increasing importance in the wider community of professional developers using a similar development method. In particular it is a step towards ISO-9001 certification.The objectives are mainly to reduce maintenance costs and to test more efficiently.THE EXPERIMENTWe will introduce SQA test tools and provide training and consulting to the employees involved with the base project. Especially people from QA will be involved, since they will be the key to reducing maintenance costs.Special attention will be given to the testing method as this is the only guarantee that we will use the tool as efficient as possible.LGTsoft currently employs 9 people, 8 of them are involved in software developmentEXPECTED IMPACT AND EXPERIENCEWe expect to reduce maintenance costs and structure our testing efforts. As a spin off we expect to get more motivated and skilled employees. We should also obtain a documented testing method.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Accelerated Seaweed Production for Innovative and Robust seaweed aquaculture in Europe'.

assistant: **Innovation**

The ASPIRE project will develop fast growing seaweed strains to strengthen Europe’s potential to thrive in an emerging seaweed aquaculture industry. Seaweed cultivation is the fastest growing aquaculture sector and provides huge potential for market growth in Europe. The red algae Palmaria palmata is one of the target species of a growing European seaweed industry due to its high content of protein (20–35%), essential minerals and its appealing flavour. Recently, there has been significant advancements in the aquaculture procedures for Palmaria, but these approaches are still mainly built on the utilisation of randomly collected wild-types of Palmaria. A targeted strain selection has therefore huge potential to increase the prospects of Palmaria aquaculture in Europe. The objective of the ASPIRE project is to screen and characterise high- yielding and robust Palmaria strains. This will be implemented utilising high-throughput phenotyping technologies using performance screening (growth, morphology characteristics and photosynthetic parameters) and metabolomic analysis (primary/secondary metabolites using GC-MS, spectrophotometer, NMR etc.). These results in conjunction with next generation sequencing (Illumina seq.) and bioinformatics tools (TASSEL pipeline) will be utilised to identify both biochemical and genetic markers of high-yielding Palmaria strains. To ensure that the results have a high impact and find their way to the commercial end-user, the project will establish a novel and easy-to-use web-based database (MySQL, VueJS) specifically designed for use by the aquaculture stakeholders. The ASPIRE project will conduct farm-level trials to validate the advantages of growing the selected elite seaweed strains in terms of productivity and overall biomass quality. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Grounding RRI practices in research performing organisations' (GRRIP) under Horizon 2020.

assistant: **Objectives**

GRRIP will embed sustainable RRI practices in 4 research performing organisations (RPO) and 1 dual function RPO and research funding organisation (RPO/RFO) (total 5 RPO&RFO) in the Marine and Maritime (M&M) sectors through Action Plans (AP) for institutional and cultural change.  This will be accompanied by establishing a platform for engagement with the Quadruple Helix (QH) for each RPO&RFO, and a platform for mutual learning between the 5 RPO&RFOs and QHs. M&M is a high priority for the EU. However, the M&M is seriously exposed to the non RRI alignment between Research and Innovation (R&I), societal actors and the environment, affecting its performance and competitiveness. Objective 1: Co-develop, implement and evaluate self-tailored RRI APs to enable sustainable institutional and cultural change for the 5 M&M RPO&RFOs to embed RRI in their governance frameworks, structures and cultures. The APs will be based on a detailed audit of the RPO&RFO current RRI maturity level and the barriers identified. RRI dimensions will be incorporated into R&I. Objective 2: Establish structures to facilitate, promote and maximise real sustainable engagement with, and input from, the QH (industry, societal actors, policy and other RPO&RFOs). Objective 3: Establish indicators and methodology for impartial Monitoring, Reflection and Evaluation cycles, to ensure provision of evidence of societal, democratic, economic and scientific impacts of institutional changes. Objective 4: Develop a sustainable Mutual Learning process across the M&M RPO&RFOs both during the institutional and cultural change project and thereafter. Objective 5: Legacy: To enable more M&M RPO&RFOs to ground RRI practices through institutional and cultural changes by a) creating a practical user-friendly RRI AP framework
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Design of artificial viruses by combinatorial protein engineering' (2002-2006).

assistant: **Innovation**

The specific delivery of therapeutic genes to defined target cell populations is a major challenge in gene therapy. This requires a sophisticated vector that is able to protect the DNA from degradation, interact specifically with cell surface receptors on target cells, cross the cell membrane and allow nuclear import of the exogenous DNA. Viral vectors are very efficient in depositing exogenous DNA into cells, but safety issues, lack of cell specificity, limited DNA packaging capacity and costs of large-sca le production hamper the general use of viral vectors for gene therapeutic application. Here, we propose to design artificial viruses" that are as efficient as viral vectors in gene delivery but are safe to use, cell-type specific and can be cost-effectiv ely produced at large scale. These artificial viruses will be designed to utilize the cellular entry mechanism of bacterial protein toxins to deliver DNA into target cells. A "survival of the fittest" approach will be used to select for artificial viruses most capable of transfecting plasmid DNA into mammalian cells from a large DNA library encoding for many different artificial viruses. This will be achieved by generating libraries of hybrid genes that combine the cell surface receptor-binding domain and t ranslocation domain of several bacterial toxins with the DNA-binding domain and nuclear localization signal of several transcription factors. Single members of the hybrid gene libraries will be transcribed and translated inside micron-sized aqueous droplet s of a water-in-oil emulsion (the artificial cells). Multiple copies of identical chimeric proteins that are properly folded will self-assemble into an artificial virus inside the artificial cell by interaction of the DNA-binding domain of the chimeric pro tein
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optical circuit switched time sensitive network architecture for high-speed passive optical networks and next generation ultra-dynamic and reconfigurable central office environments' (OCTAPUS) targeting Horizon Europe.

assistant: **Abstract**

Skyrocketing capacity demands and emerging 5G and industrial internet URLLC applications currently pose a new strict latency-oriented framework calling urgently for new radical architectural changes at the key aggregation infrastructure being in local proximity to the subscribers: the Central Offices (COs). A careful look into the CO reveals a capacity-latency predicament underlining the need for the employment of innovative technological solutions, with photonics emerging as the key enabling technology, that will establish a new NGCO ecosystem where component-level advancements can yield unparallel architectural benefits. OCTAPUS aims to deliver an agile, low-cost and energy-efficient PIC technology framework that will re-architect the NGCO ecosystem, transparently upgrading its capacity to 51.2Tb/s and beyond, through an innovative optically-switched backplane and transceiver toolkit. To realize its ambitious goals, OCTAPUS will leverage the novel integration of antimony-based Phase Change Materials (PCM) on the low-cost SiN to develop for the first time a non-volatile ns-scale optical switch technology for developing an ultra-high capacity optical backplane. OCTAPUS will also deploy a versatile portfolio of InP-based O-band optical components that will enable the realization of 50G low-power board-to-board and long-reach PON transceivers, securing 4x and 8x energy saving to existing state-of-the-art solutions, while reaching up to 37.5% cost improvement against conventional EML solutions, through its monolithic fabrication approach. Moreover, OCTAPUS will equip its novel PICs with low loss and compact interfaces to fibers, through advanced glass diplexer-embedded-interposers. Finally, OCTAPUS will synergize the developed optical components in a novel NGCO architectur