RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Large-scale integrative biology of human dendritic cells' to be submitted under Seventh Framework.

assistant: **Abstract**

The immune system is composed of different cell types that work in a coordinated manner to maintain the integrity of the organism in situations of threats or danger. Dendritic cells (DC) act as sentinels in peripheral tissue and mucosal interfaces where they integrate a diversity of danger- and inflammation-associated stimuli, then migrate to secondary lymphoid organs, and instruct naïve CD4 T cells to differentiate into the appropriate effector T cells. Hence, they play a critical role in linking innate to adaptive immunity. Three important levels of complexity characterize the DC system: 1) DC integrate multiple stimuli within complex inflammatory microenvironments, 2) these signals induce a complex output response and modify the global state of DC (environmental plasticity), 3) DC exist in different subsets generated by distinct differentiation pathways (evolutionary selection). In this proposal, we use cellular and molecular immunology combined to computational biology and modeling to study these properties at the large-scale level, and understand their interdependence in controlling DC biology. We ask the following specific questions: WP1: How DC subsets integrate combinations of stimuli at the large-scale level; WP2: How single and multiple stimuli modify DC state over time (dynamic modeling); WP3: How the DC global state influences response to a given stimulus. These questions will be addressed using a data-driven strategy combining global unsupervised exploratory analysis, gene-by-gene analysis and modeling, experimental validation of testable hypothesis. Through this systems level integrative approach, we will dissect the complexity of DC reciprocal interactions with their complex microenvironment, and hope to unravel novel mechanisms and concepts determining D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Organopalladium Derivatives of Pharmaceutical Products; Use in Synthesis of Potentially Active Drugs' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and contentIn the first part, a number of natural primary amines of pharmaceutical interest will be reacted with palladium derivatives yield the corresponding cyclopalladated compounds. For this, a method developed in the group of Prof. Vicente will be used. In a second step the obtained complexes will be reacted with carbon monoxide, olefins, alkynes, isocyanides, halogens, oxygen, oxidizing agents, etc. These reactions should afford organic derivatives or insertion products. The final aim will be depalladate these last compounds and thus to obtain functionalised derivatives of the starting primary amines. According to biological activity of the starting natural primary amines, the modified amines will have potential interest concerning drug chemistry.Training content (objective, benefit and expected impact)This research work will allow me to extend the experience I obtained during my PhD and acquire fresh knowledge in new are of great interest (palladium chemistry, synthesis of organic compounds through organometallics, the synthesis of enantiomeric pure substances). It will also permit me to learn new methods of synthesis and to approach research from a different point of view. The contact with a different type of university, culture and language will also contribute to my education as a scientist and as a European citizen.Links with industry / industrial relevance (22)The host group has contacts with a fine chemical industry (DERIVADOS QUIMICOS, Murcia) which has showed interest in the kind of chemistry we propose in this project. The synthesis of drugs' derivatives is of potential interest for the pharmaceutical industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From Understanding to Generating Meaningful Language: Unravelling the Origins of Our Words' (WordOrigins).

assistant: **Concept**

WordOrigins will establish an understanding of language generation by integrating ecological neuroscience and computational models. Language is central to human experience, enabling communication and thought expression. However, the brain mechanisms that generate meaningful language, convey coherent thoughts and elicit responses still need to be understood. I will address this gap by leveraging advances in electrophysiology (iEEG) and artificial intelligence, particularly Large Language Models (LLMs). These technologies offer the opportunity to explore unconstrained language generation and uncover the cognitive processes underlying it. The research combines two key elements: Ecological Electrophysiological Measurements: iEEG data from participants engaged in natural conversations provide insights into how the brain processes language in real-life situations; and Modeling Cognitive Processes with LLMs: LLMs offer a computational framework for modeling and interpreting language generation, generating testable predictions about how language is processed. This proposal focuses on several fundamental endeavours: Planning Multiple Words in Language Generation studies how the brain plans speech by predicting multiple future words. Modeling the Cognitive Effort of Generating Meaningful Words investigates how the brain produces more effortful, meaningful words. Multilingual Neural Encoding and Language Representation focuses on bilingual patients to understand whether early language processing is abstract or language-specific. Eliciting Meaningful Interaction Through Neural Synchronization examines whether LLM-based agents can enhance neural synchronization and trust during interaction. Disentangling Synchronization from Shared Input explores how cognitive mechanisms beyond shar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Network of Industrial Ventilation'.

assistant: **Innovation**

This INVENTNET - network is built to further joint discussions, seminars, joining the activities, creating new activities, initialising activities to European standardisation, for SME activities and for governmental regulations. This international network exchanges information, coordinates activities, stimulates and improves transfer of technologies. It also creates models to participating countries to established activities based on the pilots made in selected countries. This kind of models are for example the Finnish national network and the Finnish Guide Book for governmental use. In the COST G3 action are 17 participating countries and in the Thermie B activity 3 countries. In national INVENT programme the amount of participants was over 100. Many activities have started and there is a need for many new activities and therefore the need for networking activities has been identified.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional analysis of SCOC and FEZ proteins in autophagy using mammalian cell models and zebrafish' (2007-2013).

assistant: **Concept**

Autophagy is a conserved, highly regulated degradative pathway transferring cytoplasmic components in autophagosomes to lysosomes providing energy for cellular metabolism. In multicellular organisms autophagy is essential for tissue homeostasis and deficient autophagy is implicated in a broad range of diseases e.g. cancer and neurodegenerative disorders. To develop therapeutic strategies targeting autophagy a comprehensive understanding of the molecular protein machinery mediating and regulating autophagy is required.In a genome wide siRNA screen the host laboratory identified SCOC, a small Golgi protein, as a novel positive regulator of starvation-induced autophagosome formation. SCOC forms a complex with FEZ1, which also contains ULK1. FEZ1 negatively regulates autophagy and FEZ1 and the related FEZ2 associate with ULK1 and mTORC1 kinase complexes. The TOR signalling pathway is central in nutrient sensing. Starvation inactivates mTOR kinase leading to ULK kinase activation and autophagy induction. SCOC and FEZ also interact with the tumor suppressor UVRAG, a subunit of class III Beclin1-PI(3)K lipid kinase complexes essential for autophagy induction and progression. Autophagy is crucial for nervous system development and neuronal survival. Interestingly, SCOC and FEZ1 are highly expressed in neurons and required for axon elongation in C. elegans.I hypothesize that SCOC and FEZ are membrane-proximal scaffold and adapter proteins important in regulating and coordinating the three key autophagic signalling complexes, mTORC1, ULK1 and UVRAG-Beclin1-PI(3)K. I aim to understand the molecular details of this function and how they relate to vertebrate nervous system development and homeostasis. Our multidisciplinary approach (biochemistry, biophysics, cell biology, imaging an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Microbial soil colonization and structure formation by fungal hyphae mediated transport' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Microbes in soil drive ecosystem services defining life on the Earth. Translocation of these microbes is key features in the spatial exploration of soil. This directly impacts major ecological processes such as niche colonization and the development of soil structure, but knowledge of how microbes migrate in soil is scarce. A potential universal mechanism is fungal hyphae mediated transport (FHMT) where bacteria use hyphae of fungi as a route to translocate in a directed manner. However, this has been solely observed in the laboratory, but not in soil where single-cell level studies are restricted by technical limits. MICOL-FUNTRANS overcomes these limitations by developing and exploiting a novel system combining microfluidics, microbiological and microscopical methods to i) observe microbial movement in soil-like systems and ii) identify single involved organisms. Micro-channels will provide treatments to compare soil colonization and structure formation with and without FHMT. Ultimately, findings will be upscaled to an ecological level in a dedicated field study using a glacier forefield in the Arctic, which constitutes a unique natural laboratory to study initial soil development as ongoing climate change melts glaciers and frees vast areas of barren soil at present. The results of this project will foster an integrated view on the soil biome and push research on bacterial-fungal interactions to the centre of attention in soil microbiology and related industries.  Specifically, knowledge of migration rates of microbes in soil will impact models on nutrient distribution and efforts in bioremediation of contaminated soil. A better understanding of the initial stages of soil structure formation at the micro-scale will impact efforts in soil quality and health preservati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Debiasing the uncertainties of climate stabilization ensembles' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Mathematical models have become central tools in global environmental assessments. To serve society well, climate change stabilization assessments need to capture the uncertainties of the deep future, be statistically sound and track near-term disruptions. Up to now, conceptual, computational and data constraints have limited the quantification of uncertainties of climate stabilization pathways to a narrow set, focused on the current century. The statistical interpretation of scenarios generated by multi-model ensembles is problematic due to availability biases and model dependencies. Scenario plausibility assessments are scant. Simplified, single-objective decision criteria frameworks are used to translate decarbonization uncertainties into decision rules whose understanding is not validated.EUNICE aims to transform the methodological and experimental foundations of model-based climate assessments through quantification and debiasing of uncertainties in climate stabilization pathways. Our approach is threefold: construct, consolidate and convert. We first apply simulation and statistical methods for extending scenarios into the deep future (beyond the current century and status quo), quantifying and attributing deep uncertainties. We consolidate model ensembles through machine learning and human ingenuity to eliminate statistical biases, pin down near-term correlates of long-term targets, and identify early signals of scenario plausibility through prediction polls. Finally, we use decision-theoretic methods to convert model-generated maps of the future into resilient recommendations and experimentally test how to communicate them effectively. By advancing the state of the art in mathematical modelling, statistics, and behavioural decision-making, we strengthen the scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'On-demand generation of multi-photon linear cluster state' (ODeLiCs) under Horizon Europe.

assistant: **Objectives**

Photonic quantum devices promise a scalable way to realize real-world applications of quantum communication and computation. An integral part of this vision comprises utilizing cluster states, i.e., a type of highly entangled multi-qubit state which provides the fault tolerance needed in almost all quantum protocols. I plan to demonstrate the first on-demand multi-photon cluster state source. Although the realization of an efficient cluster state source has been a long-standing challenge, recent improvements in quantum dot spin control and the collection efficiency in photonic crystal waveguides have made this ambitious goal feasible. I will use a recently established technique to prepare and cool the nuclear spins surrounding the quantum dot. Cooling down the nuclear spins will improve the electron spin dephasing time by 20 folds to 50 ns, which corresponds to above 99% spin rotation fidelity. To improve the photon collection efficiency, I will utilize a one-sided photonic crystal waveguide which provides a near-unity coupling to a single waveguide mode. Moreover, I will use an inverse design method to improve the chip-to-fiber coupling efficiency to above 90%. The cluster state generation will be implemented with a time-bin protocol, which entangles the quantum dot spin states with the emission time of single photons. Using realistic experimental parameters, the estimated three-photon cluster state fidelity in this protocol is above 80%. The project will achieve a cluster state production rate at 5 orders of magnitude higher than the current state-of-the-art devices. The successful demonstration of an on-demand cluster state source is a critical step towards scalable and practical photonic quantum architecture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Selection and Regulation of Compartments  by Fuel-driven Phase Separation'.

assistant: **Concept**

Living cells rely on the compartmentalisation of thousands of different molecules and their chemical reactions. Remarkably, many of such compartments form by phase separation of heteropolymers controlled by sequence-specific interactions and fuel that drives reactions away from equilibrium. If we knew how such polymers with sequence-specific interactions evolve and compartmentalise in fuel-driven multi-component mixtures, we would better understand the role of phase separation in living cells and how synthetic or prebiotic cells emerge.I aim to study how fuel-driven phase separation can drive the selection and replication of hetero-polymers with sequence-specific interactions, the control of their chemical reactions and the emergence and selection of different compartments. My team and I will develop a theory for phase separation and chemical reactions in multi-component mixtures driven away from equilibrium by irreversible, fuel-driven reactions. This theory will provide a link between phenomena on the compartment scale and coarse-grained properties of sequences. First, we will use this theory to study how compartments control biochemical reactions, and how this control is determined by sequence. Second, we will investigate how sequences are selected, replicated and evolve under cyclic, non-equilibrium conditions. Third, we will use our theory to unravel how fuel-driven chemical reactions regulate formation and division of compartments, and affect selection of different compartments within a population. Our theoretical studies will elucidate the physical mechanisms and conditions which will be experimentally scrutinised by our collaborators.Our results will let us understand how living cells regulate phase separation, like the formation of stress granules by selecting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Scientific Reference System on new energy technologies, energy end-use efficiency and energy RTD' (2002-2006).

assistant: **Innovation**

A Scientific Reference System (SRS) will. This project will produce unbiased, validated, organised and scientifically agreed technical and economic information on renewable energy and end-use efficient energy technology. Moreover, comparisons with other clean energy technologies of comparable importance for sustainable development e.g., Fuel Cells, H2-vectors and Heat Pumps, will be done. In order to underpin sustainable energy R&TD-strategies, all energy technologies (incl. fossil, nuclear) will be covered in collecting all historical European energy R&TD expenditure data since the 1960s.Today, only fragmented or inconsistently categorised data is available. It lacks verification via quality systems and is not yet suited for comparative integration. The SRS resolves this: A EU-25 synopsis of available data will be co-ordinated, discrepancies will be discovered and possibly resolved, and best practice statistical methods identified. In an ERA approach, the SRS joins IEA, EU-institutional, national and academic data-providers, and experts for energy-technology, -economy and -policy research. Results will underpin future energy-economy-environment models and EU regulations with references, thus supporting sustainable energy policy and Global Change Mitigation. The project structure consists of:1) Co-ordination2) Methodology3) Technology Data Validation Synopsis4) Energy R&TD Expenditure Data Gathering [public + private]5) Consensus Building and Diffusion for Decision Support.The last work-package will integrate, publish and disseminate results from all work-packages via an open platform for stakeholders to feedback i.e., the interested scientific community, policy- and decision-makers and public. There will be a Yearly Report, and a stakeholders' conference for scientific