RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Safe with Science' (SAWE).

assistant: **Innovation**

Main objectives of Sawe project are to bring researchers to the public, increase awareness of researcher’s profession, an important role in society and the impact of their work on our safe daily live with special attention to inspire the young to embark science careers. Sawe activities will bring closer to the public, especially to youngster, also the human, caring face of scientists with sense for humor and fun. For that purpose, we will implement awareness campaign with pre-events, “Stand-up Science” in 2018, 2019 and public-call for (pre)schoolchildren. On the last September, Fridays in 2018 (att. Cultural Heritage) and 2019 ERN will be organized with renewed programs in the festive and fun atmosphere.   All Sawe events program activities aim at offering the public at large especially the young an opportunity to cooperate and socialize with researchers in a relaxed atmosphere. They include experiments, presentations, astronomy observations, workshops, researchers’ rock bands performed by researchers and students. Rawe ERN events will take place in Ljutomer, Maribor, Brežice, Koper, and Izola.   Traditional cooperation of the primary and secondary schools’ winning teams of research and innovative projects in the frame of Youth for Maribor Progress (financed by Maribor Municipality) enable most promising youngsters to inspire their fellows and connect with the real scientists.  The »European corners« will be in the heart of every RN location: Marie Skłodowska-Curie fellows' witnesses, information how one can become a researcher, EC’s various actions, programs, actions (incl. HRS4R, RESAVER) to present how EU cares about its researchers.  Finally, yet importantly, the impact assessment includes pre-study and research prior and after events using a paper-pencil method. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SUPporting high quality evaluation of COVID-19 convalescent Plasma thrOughoutT Europe' in the context of a Horizon 2020 call.

assistant: **Objectives**

Coronavirus disease 19 (COVID-19) is provoking the greatest global health crisis of this generation. With no vaccine or specific antiviral treatment available to date, the use of convalescent plasma (CP) from recovered COVID-19 patients has been considered a potential curative strategy. To demonstrate its efficacy and safety, clinical studies are ongoing or planned in various EU Member States. Unfortunately, there lacks a coordinated approach involving a large number of blood establishments (BEs) and clinical centres to harmonise protocols and guidelines, to standardise assays for characterising the potency of the plasma and to validate clinical outcome which will be of great importance to ensure that significant conclusions can be drawn. SUPPORT-E brings together major European BEs with world leading research capabilities with the aim to support high quality clinical and scientific evaluation of COVID-19 CP (CCP) and thereby achieve a consensus on the appropriate use of CCP in the treatment of COVID-19 across EU Member States. Hence, SUPPORT-E will advance the current state-of-the-art by delivering the much needed harmonised evidence-based recommendations with respect to the use of CPP in clinical trials and monitored access programmes for COVID-19 patients in Europe. Further, standardised informative in vitro assays providing scientific insights that could support such recommendations will also be developed. SUPPORT-E offers an EU-wide collaboration between Member States, BEs and clinical centres in order to close the knowledge gap and to ensure applicability of the recommendations for all EU Members States. SUPPORT-E represents the first European Union coordinated research effort on passive immunotherapy, sharing data and protocols in real-time and pooling efforts to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Euro phd summer school' (1998-2002).

assistant: **Innovation**

The project is for a second of Euro Summer Schools (2002-4) entitled Communication: Media, Social Interactions and Social Representations" continuing the 1995-2000 cycle on "Social Representations and Communication". These international intensive high level didactic stages are an essential part of the research training of post-graduate students enrolled in the European PhD on S.R.&C. and Marie Curie Fellows, and are open to a selected number of young researchers of any country. The aim of the new cycle of Euro Summer Schools is: - To widen participants' knowledge of the theories, methodologies and applications of Communication Studies in relation to the Social Representations paradigm,- To develop technological knowledge about communication and interaction in 'face to face', mediated and virtual contexts,- To provide multidisciplinary and multi-methodological research training for participants,- To maintain the Summer School's role as the leading European forum for state of the art research and research training. As regards scientific content, the International Summer School offers critical analysis and discussion of the relations between communication, the media, interaction, languages and Social Representations. It will examine the methodological consequences of different theoretical models and what is added to them when social psychological empirical research on communication is examined in the light of sociology, mass communication, socio-semiotics, symbolic anthropology and organisational studies.First year programme content deals with the specific topics of "Media and Social Representations" and concentrates on developing a multidisciplinary theoretical framework. The second year deals with "contents, contexts and social influence" and the third year with "Nets an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Enhanced Wettability and Adhesion of Polymer Film Surfaces by Electric Discharges in Silane Gas Mixtures under Atmospheric Pressure'.

assistant: **Innovation**

Objectives and content Polyolefin based polymer films, especially polypropylene films have excellent mechanical, optical and barrier properties, well suited for many industrial applications like food packaging, electrical insulation, functional coatings, etc. However they require a surface treatment to increase their surface tension at a level allowing printing, laminating or metallizing... Currently, there is no satisfactory process to achieve this goal: typical corona discharge treatment in air provides partial results, not sufficient to reach high, consistent and permanent value of surface tension. As a result water based inks cannot or only rarely be used for printing, (oil based inks encounter pollution problems), for many applications chlorine containing films are still in use industrially and the most sophisticated polypropylene films are not printable at all, in spite of their excellent properties. Two members of the consortium have demonstrated the feasibility to produce and to maintain for months, polypropylene surface tension up to 60 dyn/cm by using corona discharge treatment under specially designed active atmosphere (patented process); (vs 42-44 dyn/cm ordinarily reached with air corona discharge treatment, falling down to 3840 dyn/cm in few days). This level of surface tension is completely satisfactory for water based inks printing or functional coatings. The purpose of the research project is to reached a level of knowledge allowing industrial applications by combining, on an international level, the skills between a gas manufacturer (atmosphere control), a corona discharge devices manufacturer (electrode design, integration into industrial processes), polymer film industrial transformers (application on industrial quality films) and three well chosen u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Preclinical validation and market analysis of a microMESH implant for brain cancer eradication' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Despite tremendous progress in the treatment of several malignancies, glioblastoma continues to be the less curable form of any cancer with an overall average survival of 20 months from diagnosis. In this PoC, an interdisciplinary team of engineers, biotechnologists and technology-transfer experts will work to prove that a ground-breaking drug delivery implant – microMESH – can be engineered to deploy intracranially a chemo-immuno-combination therapy to eradicate glioblastoma and minimize its life-long complications. microMESH will be engineered to deliver chemotherapeutic drugs (taxanes) and monoclonal antibodies (anti-CD47), that normally would not cross the blood brain barrier, uniformly and deep in the tumor bed. microMESH will comprise two physically distinct compartments – a micrometric network of poly(lactic-co-glycolic acid) (PLGA) strands, carrying taxane molecules; a poly(vinyl alcohol) (PVA) microlayer, encapsulating anti-CD47. Upon deposition on the tumor mass, the PVA microlayer will dissolve in a few days releasing directly on the tumor margins anti-CD47 while the thin and flexible PLGA network will progressively conform to the surrounding surface, establishing an intimate interaction with the malignant cells, and release taxanes in a sustained fashion over several weeks. While taxanes will prevent the rapid proliferating glioblastoma cells from growing, anti-CD47 will stimulate the removal of cancer cells by resident and infiltrating immune cells. The success of this PoC will result in a preclinically validated microMESH for the treatment of newly diagnosed and recurrent glioblastoma. Upon subsequent completion of GLP toxicological and cGMP manufacturing studies, microMESH will advance to a Phase 1/2 trial expected to start as early as 2024. In this space
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'PAInful Decisions - How chronic pain affects daily decision-making' under Horizon Europe.

assistant: **Concept**

Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread pain, multiple tender points, fatigue, and impaired mental functioning. Best practice interventions for chronic pain typically include effortful exercise and long-term treatment – i.e., short-term costs (effort) with delayed benefit (improved pain and function). Problematically, adherence to these treatments is often low, suggesting that people with chronic pain may have altered decision-making related to delayed and effortful rewards. Understanding if long-term pain influences decision-making, what aspects of long-term pain contribute most to decision-making (e.g., emotional versus physical), and the neural underpinnings, are essential given clear relevance of altered decision-making to the adherence to evidence-based management strategies. The PAInful Decisions (PAID) project will address these critical aspects by evaluating delay and effort attitudes in those experiencing FM and in a group of matched pain-free controls. Additionally, I will investigate the unique role of emotions and bodily sensation perception as potential contributing factors to altered decision-making involving delayed and effortful gratification. PAID is a highly innovative and interdisciplinary project, integrating approaches from experimental psychology, behavioural economics, clinical practice, psychophysiology, and neuroimaging. This way, I will be able to comprehensively investigate the role of body-brain interactions in the context of chronic pain. Such a systematic, selective, and interdisciplinary approach to study decision-making in chronic pain is a considerable research challenge, yet the results have an essential meaning for patients’ life and clinical practice, offering to move basic and applied science forward.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated waste to energy management for preventing global warming' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The proposed project aims to deliver schemes, research and educational tools for economic and environmental evaluation waste to energy conversion, integration or the other renewable sources of energy and application in the industry and city of the future. European industrial and domestic sectors stimulates introduction of more efficient and advanced waste to energy management systems to reduce emissions, improve energy efficiency and to effectively utilise waste energy sources. It is an interdisciplinary project with several major parts: -Integrated Energy Management Framework in Waste to Energy -Life cycle analysis and supply chain analysis -The other and complementary Renewable Energy generation and management options -CO2 emissions reduction and mitigation exploiting IT tools - Integration of Renewable sources of Energy Into Energy Supply Chain - Optimum maintenance and availability -Workflows of Waste to Energy Management including the other renewables integration A MSc course will be developed, tested and made available for teaching and training in the field. The course full documentation including e-learning features and lecture handouts will be provided. The proposed Chair Holder research experience includes research in mathematical model ling, optimisation, energy efficiency, renewable energy integration, environmental protection and sustainability measures and process integration, and has extensive experience of managing major European and world-wide scale research and training projects. A synergy with the other EC project where the Chair Holder is involved will be used ' namely with EMINET Project 'Early Market Introduction of New Energy Technologies in liaison with Science and Industry'. As an important dissemination tool will be used an International Confere
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MicroRNA Isoforms for Molecular Interception of Cervical cancer using Self-samples' to be submitted under Horizon 2020.

assistant: **Abstract**

With 13,000 deaths each year in the EU, cervical cancer (CC) is one of the deadliest cancers worldwide. This is unnecessary, since CC is well detectable and treatable at early stages. For this reason, most EU countries have screening programs in place. These screening programs have had (varying) success in reducing CC incidence, however, this reduction has reached a plateau and new strategies are needed to improve screening success.An important reason for the stagnating decline in CC incidence is the relative high rate of non-compliance to screening because the gynaecological procedure to collect a sample is seen as highly uncomfortable and very invasive. Offering self-sampling options increases the participation rate in non-responder women by 30%. However, self-sampling is not compatible with the current cytology-based screening method (e.g. Pap test). There is thus a great need for the development of new, molecular screening assays for CC that can be used on self-samples.In the ERC-AdG MASS-CARE, we investigate the value of two classes of molecular markers, DNA methylation and miRNA for the detection of cervical disease in self-samples. In our analyses, we frequently observed variations at the 3’ end of the miRNA markers. Such variations (isomiRs) have great impact on their detectability by standard assays and thus specific assay development for these isomiRs constitutes a great improvement compared to using the canonical miRNA sequence. In MIMICS, we aim to select the isomiRs with the strongest association with CC which therefore have added value as disease biomarker compared to the canonical miRNAs. The identified isomiRs, which improve CC detection compared to the canonical miRNAs will be added to the panel of DNA methylation and canonical miRNAs as identified in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanism of toll-like receptor-2 recognition of bacterial lipopeptides' in the context of a Fifth Framework call.

assistant: **Objectives**

The aim of this proposal is to identify the mechanism of Toll-like receptor 2 (TLR2) activation by bacterial lipopeptides (BLP) to initiate inflammation. Toll-like receptors (TLR) plays essential role in sensing microbial molecules or pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents. Recently, Dr. Zychlinsky's group identified that bacterial lipopeptides (BLP) are the activators of TLR2. BLPs are made by all prokaryotes and they signal through TLR2 for either the activation of the transcriptional activator NF-kB and for the induction of apoptosis. However, it remains unknown if this effect occurs via direct or indirect interaction of BLP with TLR2. In this study, we will test whether BLP binds directly to TLR2 by binding assays using soluble form of the recombinant TLR2 extra cellular domain in vitro. Synthetic BLP will be used in this study to rule out contaminants bearing others PAMPs motifs. If TLR2 binds directly to BLP, we will identify the BLP-binding motif from the extra cellular domain of TLR2 receptor by site directed mutagenesis. Induced apoptosis and cell activation will be evaluated in the transient mutant cell lines. On the other hand, if BLP fails to bind directly to TLR.2 we hypothesize, that(1) BLP binds an adaptor protein in the membrane, or(2) that BLP exhibits high affinity for lipid rafts, based on its acyl moiety. Acylation seems to be a required feature for raft targeting. This aim will be approached by UV cross-linked biotinylated-sBLP (PA-bioBLP) to THP-1 membranes followed by isolation and characterization of PA-bioBLP-containing raft. This approach will provide crucial information about the composition of the sBL/TLR2 signaling platform involved upstream of the TLR2 mediated signaling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Discovery of Type 2 Diabetes Targets'.

assistant: **Innovation**

This proposal is focused on the identification and biological validation of the metabolic pathways and key regulatory genes that control insulin sensitivity in Type 2 diabetes mellitus (T2DM). We are focusing on skeletal muscle because it is quantitatively the most important tissue involved in maintaining glucose homeostasis under insulin-stimulated conditions and it is a major site of insulin resistance in T2DM. Our central hypothesis is that alterations in insulin signal transduction to glucose transport contribute to the profound impairment in whole body glucose homeostasis and T2DM pathogenesis. Identification of the defects in T2DM can lead to the development of new therapeutic strategies to prevent and cure this disease. The proposal is divided into two main objectives: We will apply: 1) target identification platforms including microarray, proteomics and bioinformatics to identify dysregulated genes in normal glucose tolerant versus T2DM subjects or genetically modified model systems and 2) functional genomics to assign a physiological role of the identified targets in Aim 1 using cellular and whole-body approaches. We will focus on the mitogen-activated protein kinase family, the energy-sensing enzyme AMP-activated protein kinase, and the lipid intermediate metabolizing enzyme diacylglycerol kinase delta. Our previous work indicates that these candidates play a role in the regulation of glucose metabolism, triglyceride storage, and energy homeostasis.