RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enabling cosmology with radio astronomy surveys: dealing with foreground contamination', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The most important tool for studying the Universe on the largest scales has been the Cosmic Microwave Background (CMB) radiation. CMB polarization provides a new window on the early Universe and will provide constraints on inflation via gravitational waves. However, the success of future CMB experiments lies in the improved understanding and removal of foreground emission from our own Galaxy. The first part of the project lies in developing our understanding of diffuse Galactic radiation through observation and modelling. This information will be used in simulations and for improving component separation algorithms and for optimising the design of future CMB space missions. A joint analysis of the forthcoming Planck data, combined with state-of-the-art low frequency foreground surveys will be made, to give the most precise CMB power spectrum from Planck.The future of cosmology at radio wavelengths lies in the mapping of the hyperfine 21cm line of neutral atomic hydrogen (HI). This is one of the key science drivers for several future radio telescopes including the Square Kilometre Array (SKA). Measuring the distribution of HI as a function of redshift will revolutionize cosmology, including dark matter and dark energy. However, like for the CMB, a major obstacle will be Galactic foregrounds, which are at least 3 orders of magnitude brighter than HI. Many of the techniques used for the CMB can be used in HI mapping, including the study of Baryon Acoustic Oscillations (BAO). We will make simulations of HI and foregrounds to study how well the HI signal can be extracted by employing techniques used for CMB data. Guided by these simulations, we will analyze data from telescopes that are soon to come online (e.g. MeerKAT, ASKAP). We will also look to develop new instrumentati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Biology and systematics of aphid hyperparasitoids' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The Alloxystinae (Hymenoptera, Insecta) are a major group of aphid hype parasitoids of potential economic importance in restricting the efficiency of the primary natural enemies of aphids. The taxonomy and systematics of these insects are very poorly understood, and little is known about their host range 2nd ecology. The project will study the twelve species of alloxystines found in a well- characterized aphid-hyperparasitoid community in southern England. Species boundaries will be established by a joint behavioural, morphological and molecular programme. The information obtained will be used to design experiments to test the theory of apparent competition between primary parasitoids, mediated by hyperparasitoids.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ultrafast Spatiotemporally-Encoding: A Superior Approach to Cancer Diagnosis by Non-Invasive Diffusion-Weighted MRI' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This proposal aims at commercializing a new method that can improve the detection and diagnosis of breast cancer.  Using ultrafast magnetic resonance (MR) acquisition schemes that span off our UltraNMR ERC AdG award, we have found ways to exploit our Spatiotemporally-Encoded (SPEN) principles together with diffusion measurements, for the rapid, safe and non-invasive diagnosis of breast malignancies. This SPENmr PoC could provide much cleaner, artifact-free alternatives than existing standards; porting these methods into clinical use could reduce unnecessary biopsies, eliminate side-effects associated from contrast agent injections, expand the base of subjects that can be diagnosed without surgery, and improve the specificity of methods based on either mammography, ultrasound or contemporary MRI. All these benefits would simply require operating acquisition and processing software packages that will arise from this project, on any of the tens-of-thousands of clinical MRI scanners used nowadays worldwide for breast scanning. We consequently envision a large potential market, and a product whose successive refinements could have a lifetime of decades.  Moreover, preliminary results indicate that the principles discussed in this proposal could be extended from breast to other human organs possessing an organized ductal/glandular structures –kidneys, prostate, pancreas– to analyses of stroke and to functional MRI.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Applying photon Up-conversion in ROtaxanes for super-Resolution microscopy Analyses' (AURORA).

assistant: **Innovation**

This multidisciplinary AURORA project focuses on the development of prototype rotaxane (molecular ring-on-thread) structures displaying triplet fusion upconversion photoprocess. Structural design will instill this process via spontaneous excited dye collisions in confined trajectories of the designed interlocked molecules to create a fluorescent state (from two combined low energy photons). Such architectures will help to collect information on molecular photon upconversion and intramolecular diffusion processes through time-resolved spectroscopies. Moreover, it will produce intermittent fluorescence blinking by which detailed analysis will afford a new methodology for super-resolution imaging, namely below the diffraction limit of light. In theory this can provide solutions to some limitations of actual approaches and impact this research field. Fluorescence modulation within these autonomous [2]rotaxanes by triplet fusion will lead to studies down to the single-molecule level (based on Stochastic Optical Reconstruction Microscopy) which will be employed to establish a new localization microscopy method (T2-STORM) and be validated through imaging commercial nanostructured biomacromolecules. Both leading French research institutes, Institut des Sciences Moleculaires (ISM) and Laboratoire Photonique Numerique et Nanosciences (LP2N) will co-host the AURORA project. The French fellow, specialist in synthetic organic and supramolecular chemistry, will be taught molecular photophysics/photochemistry and super-resolution fluorescence imaging. Additional work packages will guarantee efficient scientific advances, training, career development, management, communication and potentially technology transfer. Association of the fellow and research groups skills at the chemistry-pho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Routine performance control of radiological installations' to be submitted under Fifth Framework.

assistant: **Abstract**

The first X-ray equipment, used for digital medical radiography are in the stage of being installed at the first hospitals in Europe. A major problem is that there are at present no generally accepted measurement techniques available for measurement of significant image quality parameters describing the performance of these new devices. The objective of this proposal is to design and produce a new instrument in order to provide new means for the characterization of the new flat panel X-ray detectors. This instrument will be composed of conventional and dedicated patterns, and of multiple semiconductor sensors such as Si, MOSFET or CdTe. These different elements are distributed over a wide phantom plane, that will cover the entire area defined by a digital X-ray detector and this phantom will be easily usable at customer's site during routine qualification.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'More: motion recognition to enable human muscles, the ultimate tom-tom of muscles for a new era of motor and sport rehabilitation.' (2014-2020).

assistant: **Innovation**

The objective of the overall innovation project More is to improve the rehabilitation process making it simpler and more affordable, thanks to new sensors and services meant to help the Physical Therapists (PTs). More is a rehabilitation system based on a wearable Device able to detect movement and interpret muscular activity. The rehabilitation market is the beachhead market but More technology can be applied into fields that have remained unexplored until now Virtual Reality, athlete’s performance evaluation, astronauts’ training, and directly into Industry 4.0 to interact with future machines and robots.More project proposal addresses the “accelerating market introduction of ICT solutions for Health, Well-Being and Ageing”. The mission of More project is aligned with the mission of other projects already financed by the European Commission but we would like to underline that More technology is deeply different and extremely promising. In fact, none of these projects aim to solve the problem More was created for, according to the requests made by experts, providing a real-time feedback of the neuromuscular activation, with an extremely high spatial and temporal resolution.The only way of enhancing innovativeness and creativity is to cooperate with different stakeholders and networks as we are doing with our Advisory Board (research organizations, clinical and industrial partners, commercial and educational partners, competitors as well as web communities) experts from outside the Morecognition Srl as demostrated by the Letters Of Intent we have received and attached to the project.The objective of More SME1 is to assess the feasibility for the commercialization of More Service by means of 4 main aspects: market assesment; business model definition; costs analysis; fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Erk1/2 SIGNALING IN MEMORY CONSOLIDATION AND ALLOCATION' (ERKMEM).

assistant: **Innovation**

The growing aging population of the EU predicts a steady increase in the health and economic burden of mental decline. Hence, the study of the molecular basis of long-term memory formation is a central topic in neuroscience with forseeable social implications. The Erk1/2 MAPK signaling pathway has been strongly implicated in the consolidation of episodic, hippocampus-dependent memories, and it also supports lasting forms of neuroplasticity. However, knowledge on neuronal Erk1/2 signaling is largely limited to mechanisms of activation. If left unchecked, Erk1/2 activation can be detrimental to cognition. It is therefore crucial to understand what intracellular processes rapidly inactivate Erk1/2 following stimulation by synaptic activity, and how they contribute to memory endurance and precision. Furthermore, although Erk1/2 couples to CREB activation, the role of CREB-mediated transcription in memory allocation is poorly defined. It is also not known how the multiple synaptic inputs innervating the hippocampus support memory-associated MAPK signaling. I propose to implement a multidisciplinary approach that will experimentally address these related gaps. We will explore novel forms of Erk1/2 regulation, from the role of tyrosine phosphatases to afferent neural projections and cellular ensembles. To achieve these goals, we will use a combination of transgenic mice, viral vectors for opto- and chemo-genetics, behavioral assays, biochemistry, and confocal imaging. These studies will yield basic insights into molecular mechanisms of memory and hippocampal physiology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Flow and Iron for Pharma', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The demand for sustainable methods to build chemical bonds has led to the rise of catalytic reactions, especially using abundant and benign metals. In this context, iron has emerged as a powerful catalyst to mediate various transformations including cross-couplings between (pseudo)halide electrophilic partners and organometallic nucleophiles, usually Grignard reagents.We aim to develop a modular and versatile Flow-enabled Iron-catalysed cross-coupling protocol for Pharmaceutical applications (FI4P), leveraging the unique properties of flow chemistry to implement cross-couplings between organolithium derivatives and electrophiles. Building on the significant expertise of the academic host in this field, we will seek to harness flow technology to exert spatiotemporal control over reactive intermediates, thus ensuring the functionalisation of halide precursors with reactive lithium organyls generated in situ. The particularly high reaction rates observed in iron-catalysed cross-couplings will allow the incorporation of valuable functional groups usually incompatible with organolithium derivatives.This approach will deliver a sustainable method to assemble relevant molecular scaffolds of interest to the pharmaceutical industry. With the involvement of NovAliX, an industrial partner specialised in transferring academic innovations into industrial processes, we will eventually apply our synthetic protocol to the large-scale manufacture of valuable APIs and the generation of a small collection of molecules designed to complement our existing library for Fragment Based Drug Design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cracking the Synaptic Memory Code' (MemCode) targeting Horizon Europe.

assistant: **Abstract**

Despite their role in long-term information storage, synapses are highly dynamic and composed of rather short-lived components. In the adult mouse brain, it takes a couple of days for half dendritic spines to be replaced. Similarly at the molecular level most synaptic proteins have half-lives in the order of a week meaning they constantly need to be replaced by freshly produced ones. Thus, understanding how long-term memory can arise from unstable elements is one of todays neurosciences greatest challenges. Overturning an old dogma, I discovered using in vivo and in vitro approaches that most synapses produce their own proteins locally at both the pre- and postsynaptic sites. Interestingly, classic plasticity paradigms produce unique patterns of rapid pre- and/or postsynaptic translation. This finding is driving a paradigm shift in our understanding of synaptic function. It is now possible to decode pre- and postsynaptic memory traces formed during learning.I am now in the unique position to combine omics, cytometry, super-resolution and live-imaging techniques, and behavioral learning tasks to unravel how local production of new proteins contributes to information storage at synapses. Firstly, using live-imaging, I want to understand how and when protein synthesis is recruited in excitatory boutons. Secondly, using next generation sequencing and imaging, I will investigate how mRNA find their way to presynapses. Finally, using a genetically encoded neuronal activation tracker, I will follow the molecular changes and thus uncover the synaptic memory traces in the hippocampus and cortex after learning. Altogether, these experiments will tackle from molecules to neural networks the unresolved question of memory encoding in the brain. With an unprecedented resolution, we w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Genomics and Mechanisms in Translational Medicine Doctoral Programme' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The GenomMed programme will train international experts who are wanted in the European job market and future research leaders in translational genomics. These experts aim to solve health care -related questions in cardiovascular and metabolic diseases and neurosciences. They will have skills to create solutions and innovations to develop novel treatments in the European and global environment. Health care is globally faced with a growing burden of major age-associated diseases. New means of diagnosis and treatment are needed to survive the challenges.This will be gained by offering world class research-oriented PhD training in genomics, cardiovascular and metabolic diseases, neurosciences, and clinical adaptation of research results. In depth knowledge and methodology training will be topped up with well-planned transferable skills curricula providing the graduates with skills needed in changing career paths after their initial researcher training. Other means to achieve training goals include well-planned mobility periods to international collaborators’ research environments, meaningful secondments at intersectoral partners’ projects, and frequent exposure to interdisciplinary activities between the participating research groups.The GenomMed Doctoral Programme will take the researcher training to the next level in terms of research excellence, productive international and intersectoral mobility, and interdisciplinary exposure. Graduates will gain a unique set of research and transferable skills. Career development is a built-in feature of the training leading to increased employability of graduates in and outside academia and enhanced R&I input for the European economy and society. In pursuance of better trained PhDs, HR practices of hosting institutions will be develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Metallurgical Traditions in West Africa: Technology, Production, and Exchange of Iron and Copper in Nigeria from 700 BC to AD 1800'.

assistant: **Objectives**

METALS aims to explore the Metallurgical Traditions in West Africa with emphasis on the Technology, Production, and Exchange of Copper in Nigeria from 700 BC to AD 1800. This period is significant in Nigeria’s past due to evidence of intense metalworking traditions with emergence of social complexity.  There are two questions central to this project: first, what was the evolution of metallurgical traditions in early Nigeria in relation to technical processes and development and raw material choices? Second, how did prehistoric craftspeople in Nigeria interact with the wider region in terms of navigating production and consumption of copper and its alloys through the social network system? METALS will prioritize copper metallurgy as the more elusive technology, but will consider iron metallurgy equally alongside the copper research, not least to lay the foundation for a follow-on project proposal targeting Nigeria’s early iron metallurgy.  The project will select materials from collections of museums both in Nigeria and Europe, while training-through-research will take place on an existing assemblage at the Host institute from a site in Morocco for an in-depth study on metallurgical production and development. The Nigerian museum assemblages will be complemented by materials from targeted archaeological fieldwork at areas of prime potential in southern Nigeria. Optical microscopy, handheld X-ray Fluorescence, SEM-EDS, and lead isotope analysis will be used to reconstruct the mineralogical and compositional constituent the metal and the chaîne opératoire of their production. METALS is designed as an interdisciplinary project that integrate material science, archaeology, anthropology, geochemistry, museum studies, anthropological theory and African/global history. This pro