RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Backbone-Optimized OligonucleotideS for Therapeutics', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Therapeutic oligonucleotides (ONs) have recently gained increasing importance as new drugs. While conventional drugs are limited to targeting proteins, oligonucleotides are able to target diseases upstream at the mRNA level. This specificity in combination with their easy design renders them highly valuable. Furthermore, their applications are limitless, involving treatment of so-called undruggable diseases. The bottleneck in the development of new therapeutic oligonucleotides lies in the efficient synthesis of modified ONs. Often, these modifications require multi-step syntheses and are laborious resulting in a time-consuming process of drug development. Additionally, these modifications often negatively impact physiological and biological properties. In our proposal, “Backbone-Optimized OligonucleotideS for Therapeutics” (BOOST), we outline a methodology for efficiently modifying oligonucleotides. Key to success will be the development of novel reagents capable of intercepting solid-phase oligonucleotide synthesis due to their high reaction rate. This will enable rapid evaluation of mono- and multiple-modified oligonucleotides to assess their physiological and biological properties. Furthermore, the introduction of multiple functionalities will become possible. BOOST will serve as a new platform for designing therapeutic antisense oligonucleotides (ASOs) and siRNA. As a proof of concept, we will evaluate the most promising modified oligonucleotides in biological settings.


**Keywords:** oligonucleotide backbone modifications, solid phase oligonucleotide synthesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Empirical and theoretical assessment of the links between inner speech and insight', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Inner speech is a cognitive process of silent communication with oneself. Inner speech is driven by natural language and thus is deeply rooted in human culture while it pursues such cognitive functions as thinking, memory, planning, etc. In order to reach a more holistic knowledge of our inner voice, it requires integrating the approaches of semiotics, culture studies, linguistics, psychology and neuroscience. Exploring the functions and experience of inner speech in everyday situations drives the development of inner speech methodologies and raises the awareness of the role of culture in human cognition. One of the distinguishing features of human cognition is its unique problem solving ability. While previous research has indicated the connections between inner speech and problem solving, it remains unclear whether inner speech is experienced similarly in different types of problem solving, such as analytical problem solving or a sudden Aha! effect. The given research project explores whether the specific dimensions of inner speech (inner speaking and inner hearing) and its phenomenological properties (dialogic, condensed, etc.) can be associated with insight, or Aha! effect, and analytical types of problem solving. The research will integrate methodological paradigms from insight, semiotics and inner speech studies to quantitatively and qualitatively assess the experience of inner speech in insight and non-insight problem solving during an empirical experiment. The project aims at providing the applicant with interdisciplinary training, strengthening of the previous experience and widening career perspectives in the EU. The results of the project will explore the underlying connections between inner speech and insight problem solving, expanding our understanding of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Crack growth and fatigue of ceramic matrix composites at temperatures up to 1600'c', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The objectives of this project are to improve the fundamental understanding of the mechanisms of crack growth and push-pull fatigue in ceramic matrix fibre composites at temperatures up to 1600 rC. These objectives are to be realised by characterising and quantifying the behaviour of matrix cracks using novel techniques developed at QMW. The project will study the latest SiC fibre reinforced materials with Glass Ceramic, Silicon Carbide, Alumina and Mullite matrices. The project is an extension of current research being performed at QMW on particulate and fibre reinforced ceramic composites. The results, methodology and models resulting form the proposed research will provide fundamental knowledge which will be utilised to develop crack resistant high temperature ceramic matrix composites. Training content (objective, benefit and expected impact) This project will enable me to acquire abilities and understanding of t different areas of high temperature mechanical testing of engineering ceramic composites. It will also enable me to develop an understanding of fibre-matrix structural stability at elevated temperatures using state of the art transmission electron microscopy techniques. Links with industry / industrial relevance (22) This project is concerned with the development of materials for gas turbine applications. Experimental, stationary components of some of the materials to be studied have already been manufactured by Rolls Royce. Rolls Royce will supply materials and test specimens for the project and will be involved in the management of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'ModulAR Plug-in Mechatronic DeviceS for vibration suppression in manufacturing equipment'.

assistant: **Innovation**

In today's competitive Manufacturing Equipment market, the requirement for products combining high performances, low Life Cycle Costs (LCC) and environmental sustainability is a driven criterion. Within this sector, CeSI-Centro Studi Industriali has assumed a key role at national and international level in the development of innovative products combining high performances, flexibility and quality. Strongly committed to innovation CeSI has built a solid network with European Universities and Research Organizations to provide its customers with forefront solutions to improve machining performances.In this framework CeSI is working to develop a novel solution to minimize vibrations, an issue that can seriously compromise the quality of the workpiece, currently addressed only with costly, custom-made solutions.In MARS project an innovative, flexible, modular, plug-and-play mechatronic device based on piezoelectric stack actuators is proposed: AViA (Active Vibration Absorber), able to reduce vibration up to 70% in the frequency range of 50-500Hz, and to:•Increase productivity by up to 20% (machine can work with more demanding parameters, reducing machining steps and cycle time)•Reduce LCC by up to 15%•Improve part finishing•Double tool lifetime, reducing its wear•Reduce scraps, and therefore environmental impact AViA will be sold as add-on kit, composed by:•Mechanical HW to be installed on the Machine Tool •Electronic HW and control SW•Application Program Interface to support the user-friendly configuration of the deviceThanks to AViA, CeSI expects to increase its turnover up to +150% in 3 years after the beginning of commercialisation.The main objectives of MARS is to confirm this forecast, and to evaluate the technical feasibility of developing scalable modules, able to me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Motion Control Systems of Multi-Actuated Ground Vehicles'.

assistant: **Concept**

MOCO is based on an intensive staff exchange to promote joint research and training between 14 universities and industrial companies from 8 European countries, Japan, the Republic of Korea, Mexico and South Africa. The proposal innovates the methods of motion control and creates a comprehensive framework for the design, identification and validation of systems for the domain of multi-actuated vehicles. With a focus on driving and functional safety, energy efficiency, driving performance and ride comfort, MOCO is dedicated to improving the robust operation of automated and electric vehicles under various driving conditions, including uncertain road surfaces, severe conditions and terrains, as well as scenarios characterised by limited information and communication infrastructures. Research and innovation activities will focus on the following:(i) Development of sophisticated tools for estimating parameter variations and identifying system characteristics using hybrid model-based and data-driven methods;ii) Design of advanced vehicle motion control systems considering automated driving functions, multi- actuated configurations and different electric powertrain topologies using robust and predictive approaches;iii) Validation and verification of real-time software and hardware-based demonstrators using state-of-the-art methods;iv) Facilitate practical recommendations, based on the MOCO results, for researchers, OEMs and suppliers working on automotive and interdisciplinary applications;v) Professional development of participating research and engineering staff;vi) Knowledge transfer and promotion of the exchange of expertise between the partners.In addition to research and training, the project will focus on relevant networking, dissemination and exploitation initiatives t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rapid assay for ecotoxicity assessment in vitro to predict the effect of pollutants on marine environments' to be submitted under Fourth Framework.

assistant: **Abstract**

Assessment of hazard and risk in regulating discharges of pollutants into the environment and monitoring the effects of such discharges has created commercial opportunities for sophisticated assay systems capable of rapidly, inexpensively and accurately providing the required ecotoxicological information. The high biodiversity of bacteria and their importance in the function of natural ecosystems make them ideal target organisms for such assay systems. The objective of the project is to develop novel, user-friendly microbial assay systems for the detection, monitoring and experimental risk evaluation of pollutants being released into the environment. The system will be based on the use of an array of single micro-organisms belonging to a diverse range of genera and species. The final objective of this approach is to establish a multiple-species based in vitro test system for measuring of ecotoxicity. The research work will involve: - Development of arrays of microbial strains (isolated from aquatic environments, or collected from international collections) with defined responses towards known ecotoxic compounds. - Development or adaptation of suitable detection methods of microbial metabolic responses towards toxic compounds. - Comparisons to existing systems for evaluating ecotoxicity. The project will last for two years and involve SME's whose main activities are exploiting microbial reagents and environmental protection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated Modeling and Optimization of Quality Control, Product Reliability, and Maintenance for Advanced and Evolving Technologies' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

This proposal describes a research plan for integrated modeling and optimization of quality control, product reliability and maintenance activities that can facilitate the continued advancement of novel and evolving technologies. Recent design achievements for many evolving technologies, such as micro-electro-mechanical systems (MEMS), and micro-manufacturing systems, have been particularly impressive and offer great potential for many critical applications in aerospace, biological/medical, and nuclear areas. However, if these advanced technologies are to be delivered to the real operating environment, there must also be innovative research focusing on quality, reliability and maintenance. For MEMS and micro-manufacturing systems, traditional modeling approaches are inadequate or inefficient because new failure mechanisms have arisen, or because the high process variability and measurement error of micro-manufacturing systems create new problems for quality control, or because quality and reliability are inherently intertwined for micro devices. Successful development of new effective models for quality and reliability and maintenance can boost the commercialization of novel technologies. Meanwhile it will lead to fundamentally new perspectives on the application of quality and reliability concepts for evolving technologies. I have been researching these issues and will continue to collaborate with the researchers in the host organization and the researchers from Rutgers University (U.S.A.) and University of Houston (U.S.A.) to address this important research problem in this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CONCEPT OF OPERATIONS FOR EUROPEAN U-SPACE SERVICES - EXTENSION FOR URBAN AIR MOBILITY' (CORUS-XUAM), addressing dissemination and exploitation.

assistant: **Impact**

CORUS-XUAM is a 24-month VLD project that will demonstrate how U-space services and solutions could support integrated Urban Air Mobility (UAM) flight operations,  allowing eVTOLs/UAS and other airspace users (unmanned and manned) to operate safely, securely, sustainably and efficiently in a controlled and fully integrated airspace, without undue impact on operations currently managed by ATM. The project is proposed by the consortium that delivered the SJU CORUS U-space Concept of Operations (ConOps) in 2019, extended by the addition of UAM expertise. The activities will start with the update of the U-space ConOps, addressing the integration of UAM/UAS operations into the airspace, also identifying new U3/U4 services. The project activities will continue with the preparation and execution of six challenging VLD campaigns in six different European locations. These VLD activities will be at the heart of CORUS-XUAM and will support integrated operations of UAS/UAM and manned aircraft, and advanced forms of interaction through digital data exchange supported by integrated and advanced U-space services in urban, sub-urban, and inter-city scenarios as well as in and near ATM-controlled airspaces and airports. The VLDs will focus on different types of mission, such as passenger transport, logistic, delivery, emergency response and surveillance, using different U-space deployment architectures and state-of-the-art technologies. They will consider coordination between ATC and U-space, including interaction with ATCOs and pilots. The VLDs will combine flights by eVTOLs with other traffic and operations in the CTRs of major airports. Vertiport procedures, separation, and data services will be also demonstrated. The main results will be used to further consolidate the ConOps at the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies that target the pathobiology of cirrhosis.The objective of LIVERHOPE project is to evaluate a novel therapeutic strategy for patients with cirrhosis based on a combination of rifaximin and simvastatin, targeting the main pathophysiological mechanisms of disease progression , namely the impairment in the gut-liver axis and the persistent hepatic and systemic inflammatory response. This dual therapeutic approach is supported by preclinical data showing excellent and very promising results.We will perform two randomized double-blind trials to investigate safety, tolerability and efficacy of combination of simvastatin plus rifaximin in patients with decompensated cirrhosis in 5 EU countries (285 patients will be enrolled in two trials in DE, ES, FR, IT, UK). The expected impact is to halt progression to acute-on-chronic liver failure, the main cause of death, to decrease complications of the disease, to reduce hospital readmissions, to improve cost-effectiveness of therapy. Our final aim is to improve patients quality-of-life and increase survival as patients‘ care is the core of LIVERHOPE. Within the project we will also investigate biomarkers of response to treatment and disease progression that can be useful in clinical practice for improving the treatment of patients. We will invest our effort also in communication and dissemination activities for increasing awareness about chroni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum INteracting Topological Optics' (QUINTO).

assistant: **Concept**

Atom-light interfaces are vital for a range of potential applications in the coming “second quantum revolution”, from secure communication to ultra-precise sensors to quantum computers. A new exciting possibility is to arrange atoms in dense, regular arrays, where wave interference leads to strong collective emission. This property has been shown to polynomially or even exponentially improve the efficiency of single-photon-level applications. A frontier still awaiting a breakthrough is in the many-body regime, in particular, to expand the realm of atom arrays interacting with light toward realizing and studying exotic strongly correlated behavior.In QUINTO (Quantum INteracting Topological Optics), we will propose routes by which such systems can realize many-body states featuring topological order (TO). TOs have attracted significant interest due to wide-ranging implications ranging from possible fault-tolerant quantum computing to surprising fundamental properties such as the emergence of “anyonic quasi-particles” (being neither bosons nor fermions) and emergent lattice gauge theories. We will use the known physics of TOs within condensed matter physics as a “window” to developing the concept of many-body quantum optics, and show that, in turn, the arrays provide new ways of creating, understanding and measuring TOs.We will employ innovative, condensed-matter-inspired theoretical and numerical techniques, breaking state-of-the-art limitations (e. g. on system size), to study two routes towards quantum-optical TOs: arrays in optical cavities and “topological bands” in free-space arrays. We aim to: (i) demonstrate that long-range interactions, induced by emission and re-absorption of photons, provides a new paradigm for inducing TOs, (ii) elucidate the influence of such