RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'UNDERSTANDING AND IMPROVING THE SELECTION AND ACCEPTANCE OF FOOD FOR HEALTH PROMOTION' (1994-1998) under Fourth Framework.

assistant: **Objectives**

This project is intended to enhance understanding and achievement of short- and long-term consumer acceptance of commercial food products which can specifically contribute to meeting current dietary goals.The focus is on consumer and food characteristics associated with the selection, continued acceptance, and dietary implications of a range of nutritionally modified alternatives to traditional foods and ingredients.The work centres on a blend of laboratory and field consumer trials and surveys intended to achieve the following tasks :- assess the effect of nutritional information and consumer attitudes, as they affect sensory acceptance and purchase intent;- develop models which integrate sensory evaluation data with other relevant product attributes, including health and cost, to characterize consumers and their perceptions of foods;- assess the satiety value of selected nutritionally modified foods;- examine the influence of nutritional composition of foods for learned sensory preferences;- identify factors associated with long-term changes in acceptance of foods for health promotion.The work focuses on identifying the practical implications and applications of relationships between :- consumer characteristics, including individual attitudes and beliefs in relation to food quality and nutritional goals, and;- expectations and perceptions of the sensory and other attributes of specific food selection and long-term acceptance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Study of amyloid formation by means of solid and liquid State NMR' in the context of a Sixth Framework call.

assistant: **Objectives**

Amyloidosis is a general term for several feared diseases such as Alzheimer's disease, Parkinson's disease, the spongiform encephalopathies (Creutzfeld Jacob, mad cow diseases), type-2 diabetes etc. These diseases have the same scheme: an aggregation of a given protein, depending on the specific disease, forming insoluble amyloid fibrils. Recently, the amyloid fibrils have been showed to be heterogeneous depending on the maturation process length.This project will focus on the determination of the degree o f packing errors of amyloid fibrils from peptides of 6 to 8 residues derived from the Alzheimer peptide using:- Liquid-state NMR:The deuterium/hydrogen exchange will give some structural information as well as indication on the heterogeneity of the amyloid fibrils.- Solid-state NMR:PISEMA experiments on 15N and (15N chemical shift / 15N-1H dipolar coupling) to characterize both the homogeneous fibril structure as well as the heterogeneous structure via the so-called PISA wheel.Fast MAS 1H of largely deuterated samples combined with HETCOR experiments with 13C and 15N to get structural information.2H NMR to determine the quadru-polar tensor, which is very sensitive to the homogeneous/heterogeneous character of the molecules.14N overtone NMR to determined the homogeneity / heterogeneity of the amyloid that can be extracted from the 14N quadru-polar tensor. 14N NMR has never been done on biological molecules so far because of its very broad signal that will necessitate the use of overtone NMR with a micro-coil. All the solid-state NMR experiments will use a solenoid micro-coil recently developed in the group of Prof. Kentgens.- In addition scanning probe microscopy will be used to check the liquid-state D/H studies. The combination of all these techniques should prove to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European cytogeneticists association register of unbalanced chromosome aberrations (ECARUCA)' (ECARUCA), addressing dissemination and exploitation.

assistant: **Impact**

There exist a large variety of rare chromosomal disorders. Information about these disorders is not only difficult to obtain for patients and their relatives but for clinicians as well. Due to new techniques that enable geneticists to study the chromosomes immure detail the number of detectable chromosomal abnormalities will considerably raise over the coming years. We have started a European initiative to collect medical data on the various rare chromosomal abnormalities: the European Cytogeneticists Association Register of Unbalanced Chromosomal Aberrations (ECARUCA). One of the major goals of ECARUCA is to make the new data available to the clinicians and the patients/families involved. To achieve this we will be setting up a database that will be accessible to account holders through the Internet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fate and Activity modelling of Environmental Pollutants Using Structure-Activity Relationships' to be submitted under Fourth Framework.

assistant: **Abstract**

The proposal is directed to two alternative" assessment methodologies, namely the development and application of structure-activity relationships (QSAR) on the one hand, and in vitro test systems on the other hand. The major aims of the proposal are summarized under the four following items: I. To develop new models (QSARs) and validate present models for the prediction of properties used in the evaluation of risks of chemicals in the environment, in particular for biodegradation, soil sorption and aquatic toxicity with an emphasis on sublethal effects and alternative test systems (Toxkits). II. To develop and apply methods for the selection of QSARs based on clusterin analysis and an indication of the compound's mode of action as defined with selected in vitro test systems. III. To generate estimates based on QSARs for chemicals from the EINECS with a production volume between 10 and 1000 ton/year. IV. To apply clustering techniques to the European INventory of Existing Commercial Substances (EINECS) as a specific tool to apply QSAR to large databases. The general objective of research under I is to decrease the uncertainty of present models. The application of stereo-electronic properties calculated via quantum-chemical techniques is foreseen to be important in the development of more precise models. Apart from chemical information, knowlegde on the mechanism or mode of action is a crucial step in the selection of a model. A series of in vi tro methods will be used in determining the major mode of action of chemicals. The research will focus on several important classes of organic chemicals including aromatic amines, chlorinated hydrocarbons, nitroaromatics, phenol derivatives, several classes of alkylating agents and other chemical classes which occur frequently in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safe, Chemical-Free, Cleaning of Hospital Ward Surfaces' (CLEANWARD) under Seventh Framework.

assistant: **Objectives**

Cleanward aims to develop a novel, safe, user-friendly anti-microbial cleaning system, using titanium dioxide coated ultra-microfibre fabric that will integrate easily into existing contract cleaning equipment: it will achieve log105 microbial removal and the coating will react with water and UV to produce a highly reactive environment: this will kill all harmful micro-organisms quickly and thoroughly without the need for chemical disinfectant – all in an isolated, low water volume unit.  The cloths will then be available for re-use without running the risk of microbiological cross contamination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bone development and homeostasis-critical targets in toxicology. Research to support test-method development and human health risk assessment for dioxins and other endocrine disrupting compounds in the food chain' (BONETOX).

assistant: **Innovation**

The project aim is to provide new toxicological and epidemiological data to improve the risk assessment of dioxin and other food-derived endocrine disrupting chemicals (EDC). Focus is to clarify mechanisms behind functional diseases (osteoporosis) and structural malformations induced by EDCs through interactions with components of the nuclear receptor signalling pathways and other cell regulatory systems. We will address the hormonal cross-talk between Ah receptor (dioxin), retinoid as well as steroid hormone (estrogen) signalling pathways. Objectives will be achieved through the use of genetically modified animal models, gene array technology, proteomic and bioinformatic analysis, as well as traditional biomedical methods, and epidemiological studies. Obtained results will be used for(i) test method and biomarker development and for(ii) risk assessment purposes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Scaleable Architectures With Hardware Extensions For Low Bitrate Variable Bandwidth Realtime Videocommunications' (SCALAR) under Fourth Framework.

assistant: **Objectives**

The objective of the SCALAR project is to investigate, develop and implement a family of second generation video coding algorithms with a focus on videotelephony, which could support a large number of user applications. The emphasis will be on the development of a scaleable solution which will allow a flexible and user transparent exploitation of the available bandwidth. The software will be organised in a toolbox" which will be the basis of an integrated development environment for videocommunication applications. The demonstrators will be designed by selecting and tuning algorithms from the toolbox in order to get maximum performance according to requirements of the application. Algorithms that are developed within the project will be submitted for standardisation within e.g. the ITU and MPEG4 frameworks.In parallel with the algorithm development, research on a flexible hardware architecture shall be conducted and a real-time video communication unit will be designed and built. The generic form of this platform should provide interfaces for various communication channels and peripheral devices as well as a processing capacity for real-time execution of the video coding algorithms. Specific implementations of the architecture are developed for the applications where properties such as low cost and low power consumption are of great importance.The project intends to deliver a versatile toolbox of scaleable compression algorithms useful for industrialisation of a wide range of equipment for transmission of video signals at low bit-rates on the ISDN and PSTN networks and with a perceived visual quality equal or better than H.263. This will include a low-cost hardware platform for real-time execution of the algorithms and applications and technology verified in field tests
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'GMES network of users'.

assistant: **Concept**

Currently, the GMES user community is fragmented and incoherent, and, thus, unable to issue common and consolidated statements. GNU intends to initiate a structuring of the GMES demand side by setting up an independent platform that will become the focal point and mouthpiece of European GMES user needs, and, likewise, will foster a systematic dialogue between the stakeholder communities.GNU will add value to the various GMES related projects in that it will enable a transfer of practices and solutions, and provide measures for taking advantage of synergies and for avoiding overlaps. The project will, on the one hand, work out guidelines for effective user-provider interaction and collaboration modes, and, on the other hand, contribute to achieving harmonised and prioritised user requirements and to identifying gaps in current data delivery. GNU will analyze the GMES stakeholder landscape and investigate how GMES affects different stakeholder categories.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification and validation of new breast cancer biomarkers based on integrated metabolomics' under Seventh Framework.

assistant: **Concept**

Breast cancer is the most common cancer in women. It is therefore in the focus of approaches for the identification of predictive molecular biomarkers.  In contrast to transcriptomics, the changes in metabolite levels that are associated with tumor development and progression have not been investigated to a great extent, so far. Metabolomics is defined as the study of all metabolites in a cell, tissue or organism, and the metabolome is regarded as the amplified output of a biological system. The originality of the METAcancer approach will be the first-time application of combined technologies for metabolic profiling to large-scale analysis of patient samples in the field of translational research in breast cancer.  We will test the hypothesis that alterations in the level of metabolites can be used for a molecular classification of breast cancer and for identification of new prognostic and predictive biomarkers.  Our project is based on a large tumor biobank as well as on previous investigations of the consortium partners. We will use three different metabolic profiling technologies (GC-MS, NMR and LC-MS) to maximize the coverage of the breast cancer metabolome and apply advanced strategies for identification of individual metabolites. METAcancer’s integrated data-mining approach combines metabolomic data gained under the project with existing transcriptomic data pools for bioinformatic interpretation of cellular networks. By this strategy we will be able to go beyond the metabolite level and to identify and validate selected protein and mRNA biomarkers relevant for metabolic alterations.  This will result in a combined signature consisting of metabolites as well as key protein and mRNA markers as a basis for a  validated diagnostic system to assess prognosis and to gui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Supercritical Treatment of Process Wastewaters from Surface Treatment Industry MEtals' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Circular Materials has developed a sustainable technology to efficiently remove and recover the heavy metals present in industrial wastewaters, ideal for the surface treatment industry (in particular to recover polluting and toxic metals like chromium).While the state-of-the-art technologies generate toxic sludges to be confined to special landfills, with intrinsic risk of release of metals in the environment and groundwaters, our process operates in a completely different way. By continuously mixing in a reactor a flow of wastewater with a flow of supercritical water, the metals precipitate as a solid powder that is easily removed from the aqueous phase. This approach avoids the production of sludges (no product to dispose of), revolutionising the treatment sector and solving environmental issues. No chemicals are needed, and the operating costs are drastically reduced. Moreover, the recovered high-purity metals can be reused in the same application (perfect circular approach).


**Keywords:** supercritical water,metal recovery,heavy metals,Secondary raw materials,Surface treatment industry,toxic sludges
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Emulsions in Plant-based Edible Cellulose Microfibril Gels: Structure, Texture and Stability' (PlantEmulGel).

assistant: **Innovation**

This project aims to develop a new consumer acceptable all plant based solutions for stabilisation of edible emulsions, whose design is based on the fundamental understanding of the structure-stabilisation-flow properties of cellulose microfibril (MFC)-containing hybrid systems that are naturally found in plant cells. While there is much empirical knowledge about emulsion rheology and stability, the microscopic physical mechanisms that govern emulsion behaviour are still poorly understood, and in this particular case, for emulsions with a complexity that goes beyond the standard oil/water/surfactant systems. This lack of understanding greatly hampers the rational design of all plant structured emulsion-based products. To bridge this gap, we bring together a team of industrial and academic research groups with different, complementary expertise. By using high energy density processes for efficient deagglomeration of the CMF and proposing a new structuring approach through the continuous phase of the plant based emulsion, we will control emulsion stability. By combining macroscopic rheology and tribology with novel microfluidic tools and imaging techniques, we will establish the relation between the macroscopic flow behaviour and stability of the emulsions and the microscopic structure and interactions, and thereby increase our understanding of flowing emulsions beyond the current empirical models. It will help us to move further and provide a special focus on the mouthfeel of all plant structured emulsions. The prediction of mouthfeel texture attributes from rheology is crucial for the food industry to take a more systematic approach towards product design and optimization in order to meet consumers' preference is for natural, simple and flexible diets and other plant-fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Regulation of Inflammation by Macrophages in Chronic Granulomatous Diseases'.

assistant: **Concept**

Chronic granulomatous disease (CGD) affects children and young adults and is associated with significant morbidity, mortality and socio-economic costs. CGD is caused by the genetic deficiency of NADPH oxidase (Nox).  The characteristic lesion in CGD is the development of granulomas, or confined areas of tissue inflammation, which are characterized by the presence of macrophages (Mph) and Mph-derived multinucleated giant cells. Granulomas physiologically function to wall off microorganisms or foreign bodies. In CGD, however, granulomas persist in the absence of detectable microorganisms, thus causing severe life-threatening complications. We hypothesize that Nox deficiency results in hyperinflammation due to a Mph-intrinsic defect. The goals of this study are 1. to determine the role of ‘inflammatory’ monocytes in granuloma formation in the Nox2-/- CGD mouse model using a loss-of-function and adoptive transfer approach and 2. to analyze mechanisms by which Nox deficiency suppresses ‘anti-inflammatory’ macrophage functions that physiologically control hyperinflammation and mediate tissue repair, using genetic and molecular biology approaches. The second goal will be accomplished in collaboration with Dr. Lionel Ivashkiv (New York). Eventually, these studies aim at the identification of new Mph-specific treatment modalities for CGD. Funding of this proposal will allow the applicant to develop an independent area of research in the hosting Centre for Chronic Immunodeficiency (CCI) in Freiburg, Germany and will thus give her the chance to establish herself as an independent investigator in Europe. The hosting CCI will benefit from the applicant’s scientific and technical expertise in macrophage activation in inflammatory diseases. Integrating the applicant into the CCI will