RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Finding Flow: Negotiating diverse temporalities in migrant family life' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Based at the Center for Multilingualism in Society across the Lifespan (MultiLing) at the University of Oslo, this project will undertake a critical sociolinguistic ethnography by way of a new innovative approach - rhythmanalysis - to explore the temporal dimensions of migrant adaptation processes. Five Russian-speaking multilingual families will partake in the study, which adopts a participatory research approach. The research starts by framing migration as a time prone to social arrhythmia – a disruption to the familiar, predictable, and secure – and proposes that integration practices such as language learning and acculturation are in fact sites of conflicting rhythms and temporalities. As such, the project incorporates several layers of inquiry to understand rhythmic relations at individual, interactional, and societal levels, and how these interact. Moreover, it aims to comprehend how temporal perception correlates with meaning-making practices. If mobility can lead to new temporal experiences, then narrative and discourse become key symbolic modes for making sense of this experience. Integration – or more inclusively, adaptation – is thus conceived as an embodied, temporal, rhythmic process of habit transformation,  with ‘breaks’ in the flow of an event serving as a window into processes of change. The project also explores the prominence of past and future in migrant lives, as decision-making becomes more conscious, and new versions of heritage take shape. The ultimate goals of this research are to produce a novel theoretical framework for exploring issues of integration, identification, and belonging in a sociolinguistics of mobility, or superdiversity. In understanding how adaptation occurs, families and communities can be equipped with practical strategies to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Spinal Implant Design', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The spine consists of a series of bony vertebrae that are separated by intervertebral discs. The disc consists of the outer annulus fibrosus and the inner nucleus pulposus. The structure of the spine enables the body to twist and bend to adopt a wide range of postures. For diseased or damaged discs a surgical operation can be used to insert a spinal implant, that will attempt to replace the natural tissue and restore pain-free motion. However, current designs of spinal implants have limitations and there is a need for more highly skilled engineers to work on the design of improved spinal implants.  The purpose of this research proposal is to train a cohort of new researchers through a novel European Industrial Doctorate between the School of Mechanical Engineering at the University of Birmingham (UK) and S14 Implants (France) on Spinal Implant Design (SID).  SID will provide high quality training to develop the next generation implants and provide research and entrepreneurial training to develop the future leaders in this vital field of bio-medical engineering. SID will recruit four Early Stage Researchers (ESR) who will be trained in Spinal Implant Design, through a series of Work Packages. Each ESR will have their own individual research project and they will be registered for a Doctorate through the University of Birmingham. The training will be delivered through the research projects and through a series of workshops, with many delivered by Associated Partners. The successful conclusion of SID will result in highly trained researchers with a range of research and entrepreneurial skills that will be the future leaders in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enzymatic production of a novel class of nonionic, mild and biobased surfactants' to be submitted under Horizon 2020.

assistant: **Abstract**

A completely new class of non-ionic, biobased and mild surfactants that have been shown to have a number of advantageous technical features compared with commercial alternatives, have been produced using a novel enzymatically catalysed process (patent pending). This project aims at investigating the feasibility of a more economical route of their production to expand their market potential. The novel group of surfactants consist of oligomeric alkyl glycosides with head-groups substantially larger than those already on the market. The biocatalytic process developed is the only way such surfactants can be produced, and they have for the first time ever been produced in amounts that have allowed for their features to be established. Their mild and technically superior features render them extremely attractive for replacing ethoxylated surfactants such as the polysorbates in pharmaceutical formulations, thereby solving the problems of allergies and side-effects associated with the formation of oxidation products including formaldehyde. The new class of surfactants will, if the production cost is reduced, also be very attractive for the cosmetics- and personal care markets including a large number of European cosmetics companies. The cosmetic sector has a large need for both replacing ethoxylated surfactants and introducing “green” ingredients that can be accepted under for instance the Cosmos standard, a European standard for organic and natural cosmetics. The mild and green features of the oligomeric alkyl glycosides make them very attractive for this sector. This project aims at investigating the bottle-necks for achieving a more economical process including type of raw material, re-use of material, conversion, downstream processing etc. This will prepare for scaling up a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The prion protein in health and disease' (PRIONS), addressing dissemination and exploitation.

assistant: **Impact**

Oligomers are toxic in an array of protein misfolding and aggregation (PMA) disorders. However, the chain of events from protein aggregation to dysfunction is poorly understood. Prion diseases are marked by accumulation of PrPSc, a misfolded variant of wild-type PrPC. PrPC mediates PrPSc neurotoxicity and counteracts toxic PrPC mutants, indicating that a subversion of normal PrPC function may underlie neurodegeneration, and this may not be limited to prion disease. Here, we propose to explore these newly discovered physiological functions of PrPC in three paradigms. We show that PrPC assembles into a multiprotein complex containing a protease; neurotoxic PrPC mutants generate a smaller complex that is uncleaved. We show that neuronal expression of PrPC is required in trans for long-term myelin maintenance in peripheral nerves. We will therefore investigate the hypothesis that a fragment of PrPC transmits signals crucial for axomyelinic integrity. We show that PrPC physically interacts with both amyloid b and islet amyloid polypeptide and attenuates functional impairment mediated by these peptides. We therefore propose to test whether subversion of normal PrPC function is involved in diverse PMA disorders. We developed an ex vivo model that accurately reproduces major features of prion infections, most notably neurodegeneration. We have identified several unexpected PrPSc-induced cellular stress pathways which may be common to other PMA disorders. Using this model system, we will clarify the role of PrPC in cell survival pathways and determine the requirement for PrPC in the pathology of other PMA disorders. This proposal capitalizes on provocative recent results and, if successful, will provide valuable insights into PMA toxicity that will go far beyond prion diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of Copper Catalyzed Strategies for the Amination of Alkyl Halides Using Halogen-Atom Tranfer: Going Beyond SN2 Chemistry'.

assistant: **Innovation**

The formation of carbon–nitrogen bonds is crucial to the preparation of molecules that impact almost every aspects of our lives like drugs, agrochemicals and food additives.In text-books, creating C–N bonds is approached considering the natural nucleophilic character of N-molecules in substitution reactions with alkyl halides. In practice, these reactions are only used in the case of highly reactive substrates with low steric hinderance (e.g. primary amines + primary alkyl halides). The vast majority of substrates require forcing conditions which lead to side reactions like elimination or poly alkylation. To by-pass these issues multi-step approaches, based on extensive functional group manipulations, are still required. There is an urgent need of methods enabling to directly “plug” complex N-molecules into complex alkyl halides.This project aims at providing a conceptually novel approach to perform substitution reactions between N-nucleophiles and alkyl halides. This will be achieved by developing a radical reactivity where alpha-aminoalkyl radicals convert alkyl halides into C-radicals by halogen-atom transfer (XAT) and a copper catalyst binds the N-nucleophiles and enables amination. Upon achieving this initial goal, I aim to extend and engineer this reactivity as part of complex radical cascades leading to structurally complex chemotypes.The proposal capitalizes on recent developments of the host group that has experience in XAT and the development of catalytic reactions for the formation of C–N bonds. The development of this innovative project at the University of Manchester will create new tools in bio-organic chemistry and facilitate the preparation of high-value materials.  Its implementation will be facilitated by generating, transferring, sharing and dissemina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Condensed-phase Optical-Femtosecond-Fringe-Encoded EUV Diffraction'.

assistant: **Innovation**

As can be seen in the history of science, new techniques and methods open new research fields. In this project, the authors propose to use a new methodology approach to study thin layers of condensed matter and surfaces. We aim to perform Attosecond Transient Absorption Spectroscopy combined with femtosecond Transient Grating to study ultrafast time evolution of a model sample – solid krypton.We identify our major objectives as work packages:WP1: Attosecond XUV Transient Absorption Spectroscopy of gaseous krypton.WP2: Attosecond XUV Transient Absorption Spectroscopy in the condensed phase, the example of solid krypton.WP3: Condensed phase Transient Grating spectroscopy in the XUV spectral range with attosecond resolution.All experiments will be performed by O. Hort PhD within the Ultrafast Laser Group led by Prof. A. Baltuška (Photonics Institute, the Vienna University of Technology, Austria).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Concepts and methods for exploring the future of learning with digital technologies' (KALEIDOSCOPE).

assistant: **Innovation**

Very little of the transformation that has accompanied digital technologies is reflected in the practice of learning and teaching, or in the quality of research. Kaleidoscope's central aim is to fill these gaps in research by:(1)Integrating existing European initiatives to develop a rich, culturally diverse and coherent theoretical and practical research foundation for research and innovation,(2)Develop new tools and methodologies that operationalise an interdisciplinary approach to research on learning with digital technologies at a European-wide level.Kaleidoscope integrates existing research to develop new concepts and methodologies from a multi disciplinary and cross-cultural perspective that includes:(i) Foundations in the cognitive and learning sciences, including a socio cultural pespective, to strengthen the development of educational technologies,(ii) Conceptual and methodological bridges between educational, social and cognitive sciences, and emerging technologies,(iii)Principled design for promoting technological development enabling interactive, intelligent and cooperative learning environment,(iv) Structural and organizational models for integrating technology-enhanced learning into organizations,(v) Novel computational solutions to technology-enhanced learning environments that are adaptive, knowledgeable, cognitively sensitive, pervasive and multi-modal.Kaleidoscope seeks to explore the different conceptual frameworks of relevant disciplines in order to delineate the commonalities and differences that frame the research objectives in the field. It will do this by supporting a range of integration actions, including Jointly Executed Integrating Projects, European Research Teams, and Special Interest Groups. It will establish a Virtual Doctoral School to ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New energy-efficient process routes in industry: the one-step conversion of methane to ethylene, methanol and formaldehyde' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives The partial oxidation of methane to ethylene/ethane and to methanol/formaldehyde is being investigated in a novel gas recycle reactor-separator. The units will employ a fixed-bed catalytic or electrocatalytic reactor with an optimized catalyst composition and an optimally designed swing-bed molecular sieve trap. The project is expected to demonstrate the technical feasibility of scale-up of the novel reactor-separator for the one-step oxidative coupling or partial oxidation of methane. Technical Approach The development of direct (one-step) and energy efficient process for the conversion of methane to ethylene and to methanol/formaldehyde has been a long-sought goal. Despite intensive research during the last twelve years, the maximum ethylene and formaldehyde yields obtained in laboratory-scale reactors until 1994 was of the order of 20% and 5% respectively. In 1994, one of the participating research teams (University of Patras) developed a novel laboratory scale gas-recycle reactor separator which gave ethylene yields up to 85% for the oxidative coupling of methane (OCM)(Science 254, 1583, 1994). In this novel reactor-separator ethylene and ethane are trapped, and thus protected from further oxidation, in a molecular sieve trap in the recycle loop. They are released by subsequent heating of the molecular sieve trap. The above very encouraging results were obtained in a small microreactor (catalyst mass 0.1g, molecular sieve mass 2-3g) able to handle up to 3 ccSTP/min of CH4. The current objectives are: 1. To study the scale-up of the novel reactor-separator for ethylene production by building bench-scale units able to convert up to 1000 ccSTP/min of CH4 each to ethylene. 2. To construct and test a similar catalytic reactor-separator for the production of me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The role of miRNAs in KRAS-driven Non-Small Cell Lung Cancer'.

assistant: **Innovation**

Lung cancer is the leading cause of death by cancer in Europe. Non-small cell lung cancer (NSCLC) represents about 80% of total lung cancers. KRAS is the most commonly mutated oncogene in NSCLC, found in over 20% of patients. Since KRAS mutations are directly responsible for NSCLC, KRAS represents a relevant target to prevent NSCLC development. Yet, efforts to develop therapeutic inhibitors have failed for over 20 years, what represents an unmet clinical need in NSCLC. Thus, it is critical to identify targets of oncogenic KRAS that could unveil novel therapeutic candidates.In preliminary studies, molecular screening of downstream effectors of activated KRAS led to identification of several microRNAs. MiR-181a and b (miR-181a/b) were among the top microRNAs up-regulated upon KRAS activation. Moreover, genetic deletion of the miR-181ab1 cluster significantly impaired lung tumor development in vivo. These preliminary findings suggest a prominent role for miR-181a/b in KRAS oncogenesis. Thus, this proposal aims to dissect the role of miR-181a/b in the context of mutant KRAS to identify downstream target genes required for KRAS oncogenesis.We propose the following objectives:1. To investigate the role of miR-181ab-1 cluster in vivo and the potential therapeutic value of miR-181a and b using a genetically-modified mouse model of Kras-driven NSCLC.2. To uncover the functional role of miR-181a/b in human KRAS-driven oncogenesis using NSCLC cell lines and primary lung epithelial cells.3. To identify miR-181a/b-regulated genes functionally critical for KRAS-dependent NSCLC.4. To characterize the clinical implication of miR-181a/b-regulated genes in human NSCLC: translating in vitro and in vivo findings to human patients.We believe that results from this proposal will expand our c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Missing Key Property in Atmospheric AeRosol ChEmistry:  the Laplace Pressure' to be submitted under Horizon 2020.

assistant: **Abstract**

Fine aerosol particles are ubiquitous in the atmosphere and have important impacts on climate change and air quality. Organic compounds represent the largest mass fraction of fine particulate matter and their formation is believed to occur through the condensation of oxygenated volatile organic compounds. However, a fundamental physicochemical property of atmospheric aerosols – the Laplace pressure – has never been studied. This “missing” property is expected to have major implications for atmospheric chemistry and may explain the current gaps between ambient observations and modelling studies when evaluating the formation rates, ambient concentrations and the spatial distribution of atmospheric nanoparticles. Hence, my project aims at elucidating the key processes driven by the Laplace pressure in atmospheric aerosols and how they impact on the growth, evolution and physicochemical properties of submicron particles.  MAARvEL focuses on the smallest particles, where the Laplace pressure is expected to have the greatest impact. By exploiting recent instrumental developments and using state-of-the-art mass spectrometry techniques, MAARvEL will provide an unequalled understanding of the processes occurring within the particles. Innovative laboratory experiments will be performed to discover the central role of the Laplace pressure for; (i) condensed-phase reactions, (ii) photochemical processes, and (iii) physicochemical properties of submicron particles. A strong emphasis will be placed on quantifying the extent to which chemical processes govern the growth and evolution of atmospheric nanometre-sized particles.  By revealing how the Laplace pressure controls particle phase chemistry, MAARvEL will provide a major breakthrough to support more accurate predictions of the fo