RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fully integrated and CMOS compatible, nanoscale Quantum enhanced magnetic SENSors for scalable submiliHertz, room temperature Nuclear Magnetic Resonance spectroscopy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Quantum enhanced magnetometers (QEM) based on nitrogen vacancy centres in diamond  provide nanoscale spatial resolution and single atom sensitivity that can achieve magneto-optical imaging, thermometry and Nuclear Magnetic Resonance (NMR) spectroscopy of individual molecules. These have implications in various areas of fundamental science, biomedicine and information storage. One goal of QSENS-NMR is to solve the main challenges which prevent diamond to integrate and scale up thousands of QEM's on a single chip. These consider: challenging diamond waveguide fabrication,  incompatibility with the Complementary-Metal-Oxide-Semiconductor (CMOS) industry, scalability and commercialisation limitation given by the expensive, time consuming material growth and wafer size of diamond. QSENS-NMR aims to solve these issues by utilising Silicon Vacancy (SiV) defects in 4H-Silicon carbide (4H-SiC) material. Thanks to wafer bonding pieces from 6 inch 4H-SiC and Silicon Dioxide on Silicon wafers, QSENS-NMR will demonstrate waveguide fabrication in a CMOS compatible manner where shallow SiV defects will be implanted using scalable Focus Ion Beam. In such configuration, light can be easily coupled to simultaneously excite multiple defects. Additional fabrication of gold contacts will demonstrate the first on chip spin control and photoelectrical spin readout (PDMR) of single colour centers in SiC. The second goal of QSENS-NMR is to utilise the opportunity to manipulate and measure spin states in order to demonstrate the first submiliHertz NMR spectroscopy with SiC colour centres. By integrating simple,  microfluidic channels, multiple samples of water can be delivered to various spatial locations of the chip where high resolution NMR measurements will be achieved using the Quantum Homod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimization of fast-ion confinement against edge instabilities for future fusion reactors' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The project presented here deals with Fast-Ion Confinement OPtimization (FICOP) in magnetically confined fusion reactors. The goal of the project presented here is the characterization of the effect of edge instabilities on fast-ion confinement and the understanding of the physical mechanisms behind this interaction, as well as to experimentally explore the conditions upon which ion runaway can take place in tokamaks by studying the behaviour of fast-ions in the current ramp-up and ramp-down phases, disruptions, and sawtooth crashes. To fulfill these objectives, novel and cutting-edge data analysis techniques will be developed to be applied to fusion diagnostics, including integrated tomography techniques and deep learning. The results of this project are expected to have a direct impact on the fusion community. The problem of power exhaust in tokamaks mainly focuses on the power dissipation through the divertor plates. Therefore, the limits to tokamak operation are set based on the heat fluxes that the materials in the divertor plates can tolerate. However, an additional constraint might come from the fast-ion heat loads due to edge instabilities that may deposit power not only on the divertor plates but also in the first wall of the main chamber, often in localized areas. The results of this project may help to assess weather fast-ion heat loads to the main chamber first wall due to edge instabilities can pose an additional constraint to the operational regime of a tokamak fusion reactor, or eventually impact its design by the addition of reinforced structures. The experimental results of the project will also be used to benchmark the state-of-the-art codes that the fusion community uses to make projections towards future machines. If successful, the benchmark will st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Market forces trade-offs impacting European ATM performance' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Vista examines the effects of conflicting market forces on European performance in ATM, through the evaluation of impact metrics on four key stakeholders, and the environment. The project comprises a systematic, impact trade-off analysis using classical and complexity metrics, encompassing both fully monetised and quasi-cost impact measures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HERACLES-CP: Towards the Conversion of High Performance Research Reactors in Europe' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In the framework of the joint international efforts to reduce the risk of proliferation by minimising the use of highly enriched uranium, a new research reactor fuel based on uranium-molybdenum (UMo) alloys is being developed by the HERACLES group. HERACLES is composed of AREVA-CERVA, CEA, ILL, SCK•CEN and TUM, all organisations with a long-standing history in fuel manufacturing and qualification. HERACLES works towards the qualification of UMo fuels, based on a series of “comprehension” experiments and manufacturing developments.There are two types of UMo fuel   fine particles dispersed in an Al matrix, and monolithic foils. The qualification phase of these fuels is scheduled to begin in 2019; the project will prepare the way with an initial comprehension phase, to improve our understanding of the fuels’ irradiation behaviour and consequent the manufacturing/industrialisation process. One of the key components in the project is the SEMPER FIDELIS irradiation test, which aims at investigating the fuel swelling phenomenon and the effects of coating, with a view to arriving at procedures for fuel engineering. The challenges as regards manufacture lie in the basic elements of both fuel types’ production process and plate manufacturing. For the dispersed fuel, this includes the pin casting for the rotating electrode process and the atomization process itself. For the monolithic fuel, this concerns the development of coating for the foils. All these components are essential to prepare the fuel qualification phase.High-performance research reactors are at the start of the supply chain for medical isotopes like 99Mo. Successful conversion to lower enriched and where possible LEU fuel is therefore a key element in the mitigation of the risks surrounding the supply of isotopes a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'REFUGEES IN THE GLOBAL ECONOMY: SITUATION, ROLE, AND IMPLICATIONS: THE CASE OF SYRIAN REFUGEE WORKERS IN THE EXPORT INDUSTRY IN ISTANBUL' (FMGESI), addressing dissemination and exploitation.

assistant: **Impact**

This research aims to explore the situation of refugee-workers in the global economy and its implications for their everyday life. The forced migrant is usually seen as a person who receives aid rather than one who participates in economic production in the host country. Nevertheless, there are many studies which demonstrate the positive role of the refugees in the national economy of the host country. However, these usually focus on the role of the refugees entrepreneurs or other ‘elites’, thereby ignoring refugee-workers and their position in the global economy. As such, we could ask what role does refugee-workers play in the global economy? How does their position in this economy impact their everyday lives and thus their future plans? These are the orienting questions for the proposed research. The approach is as follows: First, we will conduct an analysis of the city and its borders. Second, an analysis of the workers’ situation. Finally we will explore in-depth the situation of refugee-workers by undertaking an explorative case study; Syrian refugee-workers in Istanbul. Here, we will use a qualitative approach with in-depth semi-structured interviews. We chose Istanbul because Turkey's economic policy makes it one of the biggest suppliers of textiles to Europe. It is also the country with the highest number of refugees in the world. Most of these are Syrian, and the biggest number of them reside in Istanbul. This research will make a great contribution toward two of the most relevant issues in the horizon 2018-2020 work program; societal resilience and market creation innovation. It will provide a better understanding and useful recommendations for policymakers on how to manage forced migration, with ‘sustainable development goals’ related to the integration of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The impact of climatic and environmental factors on personal ultraviolet radiation exposure and human health' in the context of a Seventh Framework call.

assistant: **Objectives**

We will determine the adverse and beneficial health effects of personal UVR exposure and their relationships with climatic and environmental factors that modify the solar UVR spectrum. Date and time stamped personal electronic wristwatch dosimeters will be worn to measure individual UVR exposure over extended periods. Satellite and ground station data will be gathered to establish terrestrial UVR spectral irradiance, cloud, albedo, ozone and aerosol data, at the locations and times of exposure. These dosimeters will be used in field studies in working, water, beach and snow situations in four different countries, including studies with children. The personal dosimetric data combined with diary, ground station and satellite data will show the influence of behaviour, meteorological, environmental and cultural factors on individual UVR exposure doses. The interaction between the personal exposure parameters and the satellite and ground station data will enable the development of a humanized radiative transfer model to assess the future impact of climate change on UVR exposure. This is in contrast to previous models that assume exposure to a given fraction of ambient UVR.  We will also determine the effect of UVR exposure on DNA damage and immunity in field conditions. Furthermore, the relationship between UVR exposure and vitamin D status will be determined, thus enabling a direct correlation between important risk and benefit biomarkers. We will also determine the spectral relationship between erythema, UVR-induced immunosuppression and vitamin D status. These studies will determine the value of erythema as a biological weighing function for UVR related health outcomes. Finally, we will perform a systematic review of a wide range of health outcomes from UVR exposure, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reverse Engineering Gene Regulatory Networks' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Gene regulatory networks (GRNs) are an important cellular signal processing mechanism for translating input signals intoappropriate phenotypes by modulating expression of the genome. The quantitative details of how cells process informationthrough GRNs are still poorly understood, but of central importance in a large number of biological processes. Considerableprogress has been made in mapping the topology of GRNs and more recently in deciphering the relationship betweenpromoter sequence and function. Nonetheless, it is not yet possible to computationally predict the output of most nativepromoters, nor is it trivial to build promoters that integrate signals in a novel and predictive manner. Developing aquantitative understanding of transcriptional regulation, ultimately leading to the ability to predict entire GRNs will be asignificant achievement and a prerequisite for our ability to engineer biological systems.I propose a multi-disciplinary approach incorporating biology, engineering, and computational modelling to improve ourquantitative understanding by reverse engineering GRNs in S. cerevisiae. My research group has developed a powerful setof unique, high-throughput microfluidic technologies that enable the quantitative analysis of GRNs in vitro and in vivo.Specifically I propose to quantitatively investigate the yeast phosphate regulatory network and to develop a master modelcapable of predicting output of the network under various inorganic phosphate concentrations, to develop novel approachesfor modulating GRNs using engineered Zn-finger transcription factors (TF) and CRISPR/Cas, to link GRN output to fitnessin order to develop an understanding of how networks are optimized and evolve, and to reverse engineer an exactfunctional copy of the native phosphate regul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Laser induced breakdown spectroscopy instrument for water analysis' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Scientific objectives and approach:Research of scientific and technical literature, supported by calculations and laboratory measurements, will substantiate and qualify claims and reports describing LIBS technology as potentially suitable for sub-ppm metal quantitation. A TRAF-LIBS design, in theory even more selective and sensitive, will be similarly evaluated and constrained.Novel laser and optical subsystems will be designed, exploiting recent technological advances and the dramatic reliability growth and cost reductions afforded by solid-state LED pumped lasers and by spectrometers using replicated echelles and CCD detectors. Novel concepts for a synchronous IR pumped UV wideband pulsed light source will be demonstrated in a TRAF-LIBS assembly.Prototype analysers will be designed, produced, and parametrically optimised. They will then be installed at selected end-user locations, and linked across the Internet to a central location for real-time diagnostics, operation and evaluation.Market analysis will assess demand, requirements, and market structure, allowing informed decisions to be reached in the balance in design between cost, performance and price. An evolving Exploitation Plan will pursue visibility and acceptability among regulators and industrial users, and address licensing as well as post-project production and distribution issues. An Exploitation Agreement will formalize, early in the course of the project, the terms for the ongoing and long-term cooperation between the partners.Problems to be solved:The pollution of waters with metals such as As, Be, Cd, Cr, Cu, Hg, or Pb is a growing concern. Off-line laboratory analysis is not effective in the detection and détente of acute contamination events. Environmental authorities, the agricultural sector, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Uncovering Inequality in Health and Healthcare: Data-Driven Insights for Policy Change' (HEALTHINEQ) targeting Horizon Europe.

assistant: **Abstract**

HEALTHINEQ addresses the persistent and complex issue of health inequalities across socio-economic groups. Despite significant efforts in healthcare and public policy, these disparities remain a critical challenge. The proposal aims to explore and mitigate these inequalities by investigating the underlying mechanisms, from social determinants to disparities in healthcare access and technology.HEALTHINEQ aims to achieve this through three key objectives:1/ Measurement and Data Integration: HEALTHINEQ integrates detailed health records and administrative data at a population scale in the Netherlands and Sweden and develops comprehensive, dynamic measures of health. This exceptional data allows for robust analysis of gaps in health and healthcare, how they arise over the life-course and interact with different socio-economic factors.2/ Mechanism Exploration: HEALTHINEQ leverages the rich data in combination with advanced empirical methods in a comprehensive framework. This will provide a clear understanding of the dynamic mechanisms involved, distinguishing underlying drivers from mediators, and differentiating between the incidence versus survival of diseases. The project will examine each mechanism’s relationship with prevention, detection, and treatment policies, as well as with health insurance and healthcare innovation.3/ Policy Impact: HEALTHINEQ aims to inform more effective and equitable health policies. By offering actionable recommendations and influencing high-level debates, it seeks to support data-driven policy reforms to address and mitigate health inequalities.In summary, HEALTHINEQ represents a significant advancement in the study of health inequalities, offering a comprehensive and innovative approach to understanding and addressing this critical issue. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PHYSICS INFORMED MACHINE LEARNING-BASED PREDICTION AND REVERSION OF IMPAIRED FASTING GLUCOSE MANAGEMENT' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The incidence of undiagnosed diabetes accounts for 36% European adults, while 541M adults worldwide have Impaired Glucose Tolerance (IGT), an important risk factor for further T2D development. Both IGT and/or Impaired Fasting Glucose (IFG) are intermediate glucose mishandling (i.e. intermediate conditions in the healthy-T2D transition) and are manifestations of the so-called prediabetes condition. Prediabetes itself is not an extensively studied condition compared to the overt T2D, but it is also a condition that can be reversed without the prescription usage to not proceed into T2D. The aim of our project is to develop a prototype tool for the real-time prediction of the prediabetic risk based on a series of patient-specific mathematical models (firstly developed during the FP7 MISSION-T2D project) that simulate metabolism, pancreas hormone production, microbiome metabolites, inflammatory process and immune system response. The prediction algorithm will be based on a physics-informed machine learning approach. A rich dataset of real-life data will be combined with a mathematical model  to overcome the limits of a black-box ML approach, while reducing the computational time for simulating the solutions of a heavy mathematical models and improving its prediction performances.We will collect the necessary training data (e.g., diet questionnaire, physical activity, blood metabolites and microbiome) from already existing clinical studies (used as retrospective trials) which are representative of the real-life scenarios of a prediabetes/diabetes risk insurgence in adulthood (20-80y): family history, Metabolic Syndrome, Liver disease and obesity. A newly dedicated multicentric pilot prospective observational study will be also performed, during which we will also equip the pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative high-value cosmetic products from plants and plant cells' under Horizon 2020.

assistant: **Concept**

The InnCoCells project will develop innovative and sustainable plant-based production processes for the commercial exploitation of scientifically validated cosmetic ingredients based on underutilised plant resources. We will optimise these resources for profitable and sustainable production using cell cultures, aeroponics and greenhouse/field cultivation. We will apply systematic approaches including metabolic engineering tools to optimise growth conditions and the yields of valuable bioactive, small-molecule compounds and ingredients. The optimised processes will be demonstrated by pilot-scale production and subsequent product extraction/purification. We will bring at least ten cosmetic ingredients to the pre-commercial stage. InnCoCells includes a cascade biorefinery concept in which by-products and biowaste are utilised for the extraction of further bioactive molecules. The processes will be characterised by techno-economic assessment and life cycle analysis to ensure economic feasibility and a reduced environmental footprint. The ingredients and extracts will be evaluated using a unique panel of innovative enzyme-based and cell-based assays to ensure safety and validate claimed activities based on robust scientific data without animal testing. We will implement a unique stakeholder engagement strategy, including the assembly of a Stakeholder Group to guide our research program based on the needs of industry, academia, farmers, policymakers and consumers. The consortium includes eight SMEs and one large company from the cosmetic sector among the 17 partners to facilitate exploitation. We will develop bespoke communications strategies for different stakeholders and for public engagement. We will also interact closely with the regulatory authorities in Europe. This ind