RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'MULTIMEDIA EDUCATION DATASYSTEM IN CLINICAL ONCOLOGY'.

assistant: **Objectives**

MEDICO is developing applications to break down financial, geographical and language barriers to continuing medical education in Europe. The central aim is the rapid widespread adoption of good practice through telematics-based education and training programmes, initially in the area of cancer treatment. Programme content relevant to clinical practice is seen as essential to the adoption of new technologies. Results will be widely collected and disseminated by means of ATM, ISDN, interactive satellite TV, CD-ROM, disk-based learning packages and established on-line services whose inter-operability will be investigated. MEDICO participates in the project cluster entitled: ACTION for Telematics Applications for Cooperative work of Healthcare Professionals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Systems biology strategies and metabolome engineering for the enhanced production of recombinant proteins in streptomyces'.

assistant: **Innovation**

Streptomyces has been shown to be an invaluable host for the secretory production of biopharmaceuticals and other heterologous proteins. STREPTOMICS aims to further evaluate this host as a cell factory for the industrial production of proteins of diverse origin including from mammalians, bacteria and archeae of interest for human health and environment. To enhance production, STREPTOMICS will combine genomic data, metabolic network modelling, metabolic flux analysis and proteomics. This systems biology approach will identify genes/proteins with key roles in protein secretion and their interrelationship with cell growth, secretion stress control and energy production/consumption. In addition, some key proteins of the secretion machinery, which may hinder efficient secretion of heterologous proteins, will be investigated. Based on fundamental research of these key proteins to allow rational mutations, also directed evolution, which provides an ideal system to create a protein with optimized properties, in this case for improved secretion, will be performed. Based on the obtained information and modulation, a 'toolbox' of strains will be appropriately engineered and further developed by these state-of-the art approaches such that they optimally over-secrete during fermentation.Hence, the obtained deliverables will permit the targeted manipulation of specific metabolic pathways and the modulation of key proteins of the protein secretion pathway. As a result of better understanding of the metabolome-secretome interplay strategies for improved protein secretion will be designed. These will combine better energy generation and directed energy consumption for either cell mass production or heterologous protein secretion. Successful realisation of the objectives of the project w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Water and global Change'.

assistant: **Objectives**

The Integrated Project (WATCH) which will bring together the hydrological, water resources and climate communities to analyse, quantify and predict the components of the current and future global water cycles and related water resources states, evaluate their uncertainties and clarify the overall vulnerability of global water resources related to the main societal and economic sectors. WATCH project will:- analyse and describe the current global water cycle, especially causal chains leading to observable changes in extremes (droughts and floods)- evaluate how the global water cycle and its extremes respond to future drivers of global change (including greenhouse gas release and land cover change)- evaluate feedbacks in the coupled system as they affect the global water cycle- evaluate the uncertainties in the predictions of coupled climate-hydrological- land-use models using a combination of model ensembles and observations- develop an enhanced (modelling) framework to assess the future vulnerability of water as a resource, and in relation to water/climate related vulnerabilities and risks of the major water related sectors, such as agriculture, nature and utilities (energy, industry and drinking water sector)- provide comprehensive quantitative and qualitative assessments and predictions of the vulnerability of the water resources and water-/climate-related vulnerabilities and risks for the 21st century- collaborate intensively with the key leading research groups on water cycle and water resources in USA and Japan- collaborate intensively in dissemination of its scientific results with major research programmes worldwide (WCRP, IGBP)- collaborate intensively in dissemination of its practical and applied results with major water resources and water management platforms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Silicon Films on Metals for Energy Applications' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main objective of this project is creation of porous silicon films with effective light absorbance on technically important metallic substrates such as steels, aluminium alloys and copper as well as metal-coated glass. This will give the possibility of combining structural materials with silicon for facing panels for buildings, which could be used to harness solar energy. The project aims to create highly efficient silicon films with nano-micro porous architectures, which will improve the efficiency of solar energy harvesting due to light trapping by internal reflection. The proposed concepts and methods are relevant to a wide range of applications where specifically high silicon surface to volume rates are of importance: solar cells, solar-driven generation of hydrogen, electrodes for lithium-ion batteries, precursors for production of silicon nano-particles and platforms for chemical and biological sensors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Charge carrier dynamics in metal oxides', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Transition metal (TM) oxides (TiO2, ZnO, NiO) are large gap insulators that have emerged as highly attractive materials over the past two decades for applications in photocatalysis, solar energy conversion, etc., all of which rely on the generation of charge carriers, their evolution and their eventual trapping at defects or a self-trapped excitons. Despite the huge interest for such materials, the very nature of the elementary electronic excitations (Frenkel, Wannier or charge transfer exciton) is still not established, nor is the way these excitations evolve after being created: excitonic polaron or charged polaron. Finally, the electron and hole recombine is also not clearly established because of issue of defects and trapping. In order to tackle these issues, here we implement novel experimental tools that would provide us with hitherto inaccessible information about the charge carrier dynamics in TM oxides. Of importance is the ability to detect both the electrons and the holes. Some of these tools have been developed in the PI’s group: i) Ultrafast X-ray absorption spectroscopy (XAS) will provide information about the final metal d-orbitals and about the structural changes around it; ii) Ultrafast X-ray emission (XES) will provide information about hole states. While these two approaches are ideal element-selective ones, the localization of the electron at metal atoms represents a small proportion of the electron population. Therefore, ultrafast Angle-resolved photoemission spectroscopy (ARPES) will be used to map out the band structure changes in the system and the evolution of the conduction band electrons. Ultrafast 2-dimensional (2D) UV (<400nm) transient absorption spectroscopy allows the mapping of the time evolution of both the valence and the conduction ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Large bioethanol / etbe integrated project in china and italy' (1998-2002).

assistant: **Innovation**

Aim of the project is to elaborate a technical and economic document to attract private capital investors (bank pool) for its good profitability. This document will deal about three similar already localised bio-energy integrated projects in China (Shandong Province and Inner Mongolia) and southern Italy (Basilicata) for the production of bio-ethanol from sweet sorghum integrated with CHP and DDGproduction, and its conversion into ETBE. It will preserve the environment by diminishing solid fuels consumption and reducing CO2 production, create jobs indifferent sectors (agriculture, transport, industry), promote EU-China industrial cooperation improving knowledge of European teams in developing new energetic technologies, giving them worldwide opportunities. It will imply different European institutions and be the direct application of former EC financed applied researches on bio-energy leading to the building of ETBE production plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Distributed audio-visual archives network', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The DiVAN project aims at building and evaluating a distributed audio-visual archives network providing a community of users with facilities to store raw material, and access it in a coherent way, on top of high-speed wide area communication networks.Specifically, the major objectives of the DiVAN project are: 1. To build a distributed audio-visual digital library system providing TV broadcasters and video archives owners with facilities to effectively digitise, annotate, organise and store raw material. 2. To provide coherent content-based access to large organised repositories of audio-visual information via user-friendly interface paradigms, on top of high-speed wide area communication networks, in an efficient, effective, flexible, and secure way, paying specific attention to interoperability issues and considering the upcoming content-based MPEG-4 video compression standard. 3. To demonstrate and assess the applicability and acceptability of the DiVAN system through experiments and involvement of real actors, through the establishment and population of a distributed audio-visual digital library using material lying on the traditional archives of major European Broadcasters and audio-visual Institutions. These objectives imply: - Development, integration, and demonstration of advanced multimedia technology. Specifically, the key technological areas include digitisation-compression standards, multimedia storage servers, high-speed networks, video annotation and retrieval techniques, and distributed object technologies. - Selection of a considerable amount of representative audio-visual material that will be used as the basis for experimentation. - Definition of realistic application scenarios that will fully exploit the opportunities offered by the materials that are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Airbag bicycle helmet based on One Piece Woven technology' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Cycling is a crucial mode of transport in the common European challenge of making transport sustainable: cycling is energy efficient, environmentally friendly and very suitable for short distances.The use of helmet is not widely accepted by urban cyclists due to practical reasons, they are uncomfortable, cumbersome to carry around, look hideous, make sweat and ruin personal style. Hövding represents a head protection for cyclists unlike any other product on the market – an airbag for cyclists. Compared with traditional helmets, Hövding is more than three times better shock absorbance, can withstand multiple mpacts in one accident, reduce head rotation, provides much larger protection area and stabilizes head and neck in the accident. Hövding is easy to fold and bring in bag, discrete, works with a hat. Hövding has been sold during around 3 years. Now we focus on expanding from initial test sales in Sweden to successive rollout across Europe. However some limitations such as our quite manual manufacturing process impede us to scale up our product and meet our growth ambitions. The overall objective of our business innovation project is to automatize the manufacturing process of our airbag for cyclists called Hövding with the aim of scale-up and reduce production costs. To this end, airbag will be designed and manufactured in one piece with woven seams eliminating the need of conventional sewing. We also want increase the add-value of our airbag add Bluetooth Low Energy connectivity and developing an outer shell based on nanotechnology textiles to obtainsuperior lightweight, good water and stain repellent properties. Hövding addresses a market of an estimated 150 million adult cyclists in Europe alone and clearly contributes to EC policies intended to improve road safety
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Endothelial immunosuppressive mystery genes for alternative immunotherapy: artificial intelligence-driven target discovery and lipid nanoparticle/RNA-based target validation' (MystIMEC) under Horizon Europe.

assistant: **Objectives**

Compared to my previous Advanced ERC grants, this proposal is fundamentally different not only concerning its topic but also regarding its ambition to offer greater societal impact by coupling knowledge gain tighter to translation. It promises to obtain new insights in an understudied endothelial cell (EC) subtype with immunomodulatory gene signatures (coined IMECs), highly relevant for alternative immunotherapy development. Indeed, silencing immunosuppressive genes in IMECs offers unprece-dented opportunities to improve the efficacy of and to overcome the resistance to current anti-cancer immunotherapy, to which the immunosuppressive tumor endothelium contributes. To identify previously unknown/unmined (virgin) drug targets, we also focus on mystery genes, lacking func-tional annotation / PubMed reports (comprising 30% of the human coding genome). We developed: (i) an innovative artificial intelligence (AI)-based tool (SCMYSTERYDENTIFIER) to predict new immunosuppres-sive functions for endothelial mystery genes; and (ii) a revolutionizing (REVOLT) technology (based on injecting EC-selective lipid nanoparticles containing sgRNA in mice expressing Cas9 selectively in ECs) to generate EC-specific knockout mice rapidly (days)/inexpensively (300/mouse) at an unprece-dented scale in order to validate these targets. Demystifying the mystery genome offers formidable opportunities for knowledge gain and therapy development. We will validate 50 new EC targets and aspire to identify and patent 5 previously unknown targets for alternative IMEC-based immunotherapy. The SCMYSTERYDENTIFIER tool can be made generic to discover any type of function for mystery genes in any cell type, while the REVOLT technology promises to revolutionize the pace of genetic research in the vascular biol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigations on mechanisms for maintenance and regeneration in the ageing muscle : development of guidelines , diagnostic tools and a view to therapies' (1998-2002).

assistant: **Concept**

Diminution in muscular performance is a major cause of disablement in old age. This loss appears to be a multi component phenomenon. We will investigate whether and which factors within the muscle itself are responsible for this decline. A major goal of our network is to determine changes in the behaviour of the satellite cells during ageing (i.e. numbers, proliferate capacity in vitro and in vivo, gynogenic program, calcium homeostasis). Satellite cells are the only source for maintenance, growth and regeneration of muscle tissue. Important aspects of the contractile apparatus and capillarization will be investigated as well. Most work will be performed on human tissue in a cooperation of outstanding basic scientists and clinical partners. A diagnostic tool to predict trainability of muscle in the aged will be elaborated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modal analysis of atmospheric balance, predictability and climate', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Despite large progress in modelling of atmospheric processes and computing capabilities and concentrated efforts to increase complexity of the atmospheric models, the assessment of accuracy of natural atmospheric climate variability, its predictability and interaction with anthropogenic influences is far from well understood. This project aims to advance scientific understanding of dynamical properties of the atmosphere and climate systems over many spatial and temporal scales.It is proposed to study atmospheric balance and predictability in terms of the energy percentage which is associated with various types of motions, balanced or Rossby-type of motions and unbalanced or inertio-gravity motions. This representation of the atmosphere is called the normal-mode function representation and it is a heart of methodology proposed in this project.The projects is built on theoretical foundation set in 1970s at the National Center for Atmospheric Research in USA and with the support of original developers it will apply normal-mode function representation tool to issues for which it could not have been reliably applied earlier. The project relies on accomplishments of the proposal’s PI in weather and data assimilation modeling which this project will extend to new research areas.The project will quantify balance in analysis datasets and ensemble forecasting systems and use the results as a starting point for climate model assessment for their ability to represent the present climate and possible changes of balance in model simulations of future climate scenarios. Results will allow dynamical classification of climate models based on their balance properties. Predictability issues will be studied by comparing temporal variability of balance in the forecasts in terms of various s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Strategic Targets for 2020 - Collaboration Initiative on Biorefineries' (STAR-COLIBRI).

assistant: **Innovation**

For the first time in Europe a real critical mass along the whole value-chain, and in all aspects of the biorefinery concept, will be achieved by the close collaboration of five industry-driven European Technology Platforms, five excellent research partners with complementary expertise, and the International Civil Society Organisation IUCN, who will validate the impact on the global sustainability of the results. The collaboration in this Coordination and Support Action is called Star-COLIBRI, and its main objectives are to promote coordination and work to overcome fragmentation in the field of biorefineries research; to facilitate information exchange and cross-fertilization; to support break-through innovations by speeding up and facilitate industrial exploitation of research results. The Star-COLIBRI project will accomplish these targets by working in two parallel but mutually dependant processes: The first process has longer term objectives and it will provide a framework for collaborations and information exchange, common vision and a roadmap for 2020. It will also directly contribute to policy initiatives such as the European Lead Market Initiative on Bio-Based Products. The second process has shorter term objectives and aims to the immediate support and coordination of ongoing biorefinery research projects with potential high impact. The new strategy developed for this is called StarClustering. Better coordination of national research funding through an ERA-Net Liaisons Office will also be achieved.