RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Digital die design system', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

In order to reduce the vehicle weight, new materials such as aluminium alloys and high-strength steels are introduced in cars. Forming of such materials becomes more complex and needs a better characterisation of the materials and more reliable and efficient software for predicting forming defects. The aim of this project is to improve the ability of numerical codes to predict forming defects, an essential step towards a virtual try-out of the dies with theaid of a DIGITAL DIE DESIGN SYSTEM (3DS).The project will have three objectives:- Development of user-friendly methods and software for evaluating forming defects;- Improvement of the ability of numerical software to predict forming defects;- Selection of appropriate physical models and their identification.The project will contribute to reduce materials waste, fuel consumption and gas emission directly related with car weight. This will save time, money, resources.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Research Reinforcing in the Western Balkans in Offline and Online Monitoring and Source Identification of Atmospheric Particles' (WeBaSOOP) under Horizon Europe.

assistant: **Objectives**

Information on atmospheric particles(PM) and related hazards is based on monitoring data. The main metric used is PM mass. This does not sufficiently account for physical, chemical and biological properties of PM that determine toxicity and bioavailability. Such properties can only be assessed by advanced methods. These are being developed in several European activities, including research infrastructures ACTRIS and RI-URBANS. WeBaSOOP will reinforce in Serbia coordinator (VINCA) and partners institution (IRMB,PHIB) research hub by knowledge and skills related to PM monitoring and assessment, with the aim of association with the infrastructures. We will introduce innovative observing metrics and methods and address networking gaps.The internationally leading partners (NILU,CSIC,UNG,DEAKIN)have each central roles in the infrastructures and extensive knowledge of and experience with the European research system. They will gain regional understanding, new data and networks. WeBaSOOP research and associated training will focus on particle size distribution and composition including novel organic source tracers and black carbon, by online and offline monitoring and assessment methods.We will introduce oxidative potential as proxy for health effects. We will generate new data and knowledge and close the information gap on PM in Western Balkans.We will use the new generated data for novel source apportionment. This will trigger new research opportunities.  WeBaSOOP knowledge and data will be shared with stakeholders responsible for pollution mitigation or prevention and for compliance with European acquis. Further, we will enhance generic research-administrative skills of partners by dedicated training. We will enable the participating institutions to become partners in discus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'BIOSENSOR FOR AGRICULTURE AND FOOD INDUSTRY'.

assistant: **Objectives**

The aim of the project is to introduce a rapid sensor technology into food processing and food quality control. This technology is based on an innovative biosensor using enzymes as detection element and an electrochemical system as transducer. This biosensor should permit the detection of specific food components such as sugars (i.e. fructose), alcohols (i.e. ethanol), organic acids (i.e. malic acid), etc. in various matrices (fruit juice, dairy products, wine, etc...).The proposed biosensor shows innovative characteristics which overcome some of the drawbacks of current sensors. The new biosensor will be a low cost and handy instrument, which can be operated by unskilled people, it permits an absolute measurement of the above compounds without requiring calibration.Furthermore measurements are independent of the enzyme activity and therefore the biosensor can be used after long storage time. Laboratory prototypes of the sensor have been successfully used in various situations. To introduce this technology into food processing and food quality control. The biosensor will be customized (improved user interface will be developed) and implemented to a large scale production.In parallel analytical procedures will be developed to measure compounds of end-user interest. The implemented biosensor and analytical procedures for specific compounds will be validated by traditional methods in artificial and real samples.The validated biosensor will be tested by end-users operating in various sectors (fruit juices, wine) with a feed-back process to optimise and diffuse the technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dissecting and targeting ubiquitin networks in the course of bacterial infections' (Ub-BAC) targeting Horizon 2020.

assistant: **Abstract**

Ubiquitination represents one of the most versatile post-translational modifications in eukaryotes and is involved in regulation of numerous cellular processes. Despite prokaryotes lacking this system, facultative intracellular bacteria like Salmonella, Shigella and Legionella have evolved multiple strategies to manipulate the host ubiquitin (Ub) system to their own benefit. This proposal is focussed on gaining a fundamental understanding of the Ub system in the course of bacterial infections. We will employ advanced quantitative proteomics to perform a global analysis of the dynamic changes in the ubiquitinome and phosphoproteome of epithelial cells and macrophages upon infection with Salmonella, Shigella and Legionella. The comprehensive datasets will constitute an invaluable resource freely available to the scientific community. We expect to identify novel pathways triggered by selected bacterial ligases and will characterise their contribution to pathogenicity and virulence, as well as their suitability for being targeted in a therapeutic setting. Both medicinal chemistry and structural biology approaches will be exploited to identify inhibitors for NEL-type bacterial ligases. Hypothesis-driven projects within the work program focus on (i) a novel chemical modification of Ub controlling Legionella infections and (ii) the observation that Ub chains on Salmonella can form nanoscale clusters that recruit and activate multiple signalling pathways within the host cell. Super-resolution microscopy and single-molecule imaging will be used to visualise and dissect these Ub-triggered complexes.Taken together, the combination of unbiased global proteome analysis and hypothesis-driven projects creates a unique scientific program within the biomedical field of understanding and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'GAS SEEPS AND SUBMARINE SLIDES IN THE EASTERN MEDITERRANEAN: TOWARD COMPREHENSIVE GEOHAZARD PREVENTION'.

assistant: **Innovation**

The objectives of this proposal are to study the shaping mechanisms behind gas seepage and slope stability in the Levantine basin (eastern Mediterranean), and to understand the geological forces shaping and controlling sedimentary basins under similar conditions. Fluid escape features and mass transport deposits are common in hydrocarbon-prone basins. Thus, studying the relationship between these features in the Levantine basin is crucial for hazard assessment and risk mitigation for safe hydrocarbon recovery.Massive hydrocarbon reservoirs have recently been discovered in the, up to now, under-explored Levantine basin. Wells and boreholes show high quality gas trapped in lower Miocene sandstones at water depths over 1500 m. The estimated amount of gas in place for these fields is world class: with 25 trillion cubic feet. These giant sub-Messinian salt gas discoveries in the Levantine basin were considered, at the time of their finding, the largest of the last decade, thus bringing the eastern Mediterranean into the limelight. Israel’s energy sector is set to undergo significant changes that could transform the country into an exporter of natural gas. Increasing numbers of offshore constructions including undersea pipelines and oil rigs in relation to the development of these hydrocarbon reservoirs, require detailed hazard assessments. Gaining reliable data about frequency, causes and consequences of mass movements and their interplay with gas seepage is imperative prior to successful recovery and development of these fields.The presence of fluid flow signatures piercing deep Messinian salt layers and reaching shallower depths requires the implementation of a comprehensive geological study of the Levantine basin based on the interpretation of 2D and 3D surveys, coupled b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Peripheral nerve Gel-based Orientation (Peripheral nerve injury recovery using Gel-based Orientation)' (PeriGO) targeting Horizon 2020.

assistant: **Abstract**

PeriGO will pave the way for the commercialization of a unique, first-of-its-kind peripheral nerve repair strategy, as it uses an injectable, biocompatible hydrogel that provides directionality through controlled guiding elements. The properties of the smart material Anisogel, initially developed in the ERC project ANISOGEL to repair spinal cord injuries, provide a sophisticated, superior alternative for peripheral nerve regeneration. The final product can be injected inside a bridging blood vessel or artificial hollow tube after implantation to direct regenerating nerves across the injury site. PeriGO comprises 3 key actions to advance a quick translation from the laboratory to the clinic: We will 1) establish a sterilization method and a packaging/application system to perform pre-clinical tests, 2) verify the handling and efficacy of the product in a rat sciatic nerve lesion model in cooperation with the Department of Plastic Surgery at the University Hospital in Aachen, and 3) complete a market study and business plan to bring PeriGO into the clinic.  PeriGO addresses essential issues associated with peripheral nerve regeneration. While the current Gold Standard of autologous nerve grafts creates a secondary defect, artificial bridging approaches for nerve gaps only reconnect short distances (< 3 cm) with marginal success. Features absent in the commercially available nerve tubes are guiding structures, controlled degradation, and a good interface with the damaged nerve stumps. The PeriGO platform will overcome these limitations as the material 1) is injected as a liquid to make a tight contact with the injured nerve and to adapt to the shape of the bridging tube before gelation, 2) provides unidirectional guiding elements, and 3) presents tunable material propertie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating the neural ensembles underlying the encoding of memory in zebrafish' (ZebraHipNetwork).

assistant: **Concept**

How animals respond to their environment largely depends on their past experiences. In fact, understanding how these subjective experiences are formed and how they influence behavior is one of the ultimate goals of neuroscience. However, how memories are established in the brain is still poorly understood in mammals and even less in primitive vertebrates. Although the formation of memory has been largely studied at the single-neuron level, more recent studies have shown that the establishment of memory traces necessitates the interactions between multiple brain regions including the cortex, amygdala and hippocampus. Yet, imaging across these vast brain areas is very challenging in mammals due the complexity and size of the mammalian brain. Since there are accumulating evidence illustrating that the hippocampus and amygdala are evolutionary conserved across vertebrates, here, I will use an optically transparent and genetically amenable vertebrate model that allows for brain-wide imaging of neural activity: the juvenile zebrafish. First, I will use electrophysiological and immunochemical methods to identify the major neuronal populations in the fish’s hippocampal homologue (WP1). Next, I will use a combination of electrophysiological recordings and whole-brain two-photon calcium imaging to investigate the connectivity architecture and synaptic organization of the neural ensembles of the hippocampal homologue in zebrafish brain explants (WP2). Finally, I will characterize what kind of information does the hippocampal homologue encode during learning and how does the brain-wide neural activity changes over the course of learning in behaving animals (WP3). Collectively, this project will identify, for the first time, key fundamental neural mechanisms that underlie memory for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pneu-Haptics: Unlocking the Potential of a Haptic Cueing System for Driver Communication, Collaboration and Control with (Semi-) Autonomous Vehicles', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

There is an on-going societal shift from manual vehicles to semi-autonomous vehicles, which will fundamentally alter the practical, emotional and somatic experience of driving cars, trucks, trains, and even tractors. At the same time, innovations in strategies for communicating with the driver have not advanced beyond the utilization of visual and audio modalities. As the driving experience becomes more complex this has led to an overwhelming cognitive experience consisting of excessive blinking and beeping. Pneu-Haptics is a new approach to this problem of communication with the driver. Making use of pneumatically powered haptic cues embedded within the seat, Pneu-Haptics utilises the intelligence that resides in our bodies by touching and gently moving larger body parts in ways which can somatically and intuitively create conditions for action or emotion. For example, by dynamically changing the support of a driver’s back area, the driver’s posture can be altered from a slouched and more relaxed position to an erect and alert postural state that readies the driver for taking back control of the vehicle. This ERC PoC project will evaluate whether such an approach can improve the passive safety of the driver by moving beyond approaches which rely on pure symbolic meaning and cognitive reasoning. While at the same time make the driving a smoother and non-disruptive experience. The goal of the Pneu-Haptics PoC project is to demonstrate the effectiveness and value of Pneu-Haptics as a new modality for enabling communication and collaboration between a driver and a vehicle in a way which is a dignified aesthetic experience. Together the research team will produce a robust demonstrator for testing and demonstrating to Pneu-Haptics to relevant industries, establish a ‘killer’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dynamics of second messengers in axon guidance: decrypting the codes' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The mature nervous system is an intricate network in which neurons are connected to specific partners. The construction of the network requires directed growth of axons towards their appropriate targets during development and during neuronal regeneration after a lesion. Axons must navigate through a complex environment where they are guided by a combination of attractive and repulsive molecules. Cellular second messengers, particularly calcium and cyclic nucleotides – cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) – are critical for responses to guidance molecules and axonal pathfinding. Recently, the temporal structure of calcium signals has been shown to have a key role in regulating growth cone behaviors, but the temporal components of cAMP and cGMP signals are largely unknown. The present project proposes to investigate the involvement of second messengers during the midline crossing of spinal commissural axons in vivo. We will first identify the crucial second messengers for the guidance of those axons in the Xenopus spinal cord in vivo. Second, we will use newly improved cyclic nucleotide FRET probes and fluorescent calcium sensors to determine the temporal dynamics of cAMP, cGMP and calcium signaling (the frequency of transients and sustained variations in their intracellular concentrations) in vivo in the growth cones of spinal commissural interneurons. We will then investigate the respective roles of temporally restricted and sustained variations of second messengers in the guidance of commissural axons in vivo, by imposing different frequencies of transient or sustained perturbations of cAMP, cGMP and calcium. Finally, we will investigate the interdependence of these signaling pathways by imaging one second messengers while man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Virtual tissue staining by deep learning' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Our goal is to create a virtual tissue-staining device to replace manual chemical-staining techniques by integrating optics and deeplearning.Chemical staining of cell components plays an essential role in biomedical and pharmaceutical research and practice. Cell structuresof interest are highlighted using various chemical stains and imaged with the appropriate optical setup. However, these techniquesare often invasive and sometimes even toxic to the cells, in addition to being time consuming, labor intensive, and expensive.Recently, the use of deep learning has been proposed as a way to create images of virtually stained cell structures, thus mitigating theinherent problems associated with the conventional chemical staining. However, these methods are usually specialized for a specificapplication and, thus, highly dependent on the setting of the optical device used for acquiring the training data.In order to make virtual tissue-staining more accessible to end-users, we propose a device based on a simple optical system with anintegrated deep-learning-powered virtual-staining software.This is an ideal moment to enter the virtual tissue-staining market because we can gain a first mover advantage. Further, we can takeadvantage of the fact that the tissue-staining market is expected to grow with a compound annual rate of roughly 8.5% until 2025 (upto 3400M USD), and to continue to grow for the foreseeable future.As part of this project, we aim to launch the startup company IFLAI to commercially exploit our virtual-staining technology and theprototype we will develop. With the startup IFLAI, we aim to provide ~20 jobs to university-educated individuals in the EU within thenext 5 years. IFLAI has already received initial funding and support from two different organisations tha