RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Network of European proficiency testing schemes concerning the chemical analysis of occupational and environmental air samples' under Fourth Framework.

assistant: **Concept**

Most of the European Union's member states operate their own proficiency testing schemes in the occupational hygiene area, emphasising the importance most countries attribute to the validation of analytical results. With regards to harmonisation in this area there are many differences between the schemes at many levels. These include matters concerning their relationship with legislation, national status, types and quality of proficiency testing material, analytical range and priorities concerning further development. The first meeting of the network in Brussels in April 1997 discussed the objectives of the project and the actions necessary to achieve them. 1. To act as a steering group and umbrella organisation for the development and harmonisation of proficiency testing schemes in Europe. 2. To develop research initiatives, if required by the steering committee, to improve the quality of proficiency testing standards. 3. To improve the quality of analytical performance in occupational hygiene and environmental measurement in industryA draft compendium has been developed to describe the services provide for each. scheme. A common statistical protocol has been agreed on as the basis for comparison. All of the schemes have been compared with the ISO Guide 43 and any deficiencies identified. Scheme organisers are to provide participants with estimates of uncertainty of the assigned value. All schemes are encouraged to accept laboratories from other member states. Members are to evaluate data to determine if standards of assessment are comparable and to supply formal proposals for new analytes for the European network.To achieve harmonisation it is necessary that schemes are comparable with each other. This will be achieved by the comparison of each scheme to ISO Guide 43.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The mechanism by which cohesin controls gene expression' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

How cells retain, lose, and regain developmental plasticity is poorly understood due to ignorance of the molecular mechanisms regulating gene expression. Each gene is regulated by a unique set of factors and as a consequence the trans-acting factors and cis-acting chromatin modification states regulating a given gene are extremely rare. Transcription is affected by events taking place many thousands of base pairs away from the start, a property enabling developmental and evolutionary plasticity, presumably made possible by DNA looping or translocation of factors along chromatin. Most factors regulating a given gene function at many other genes, complicating interpretation of the consequences of altering the activity of such factors. It is difficult to exclude the possibility that phenotypes are knock-on effects. This could be surmounted if it were possible to observe individual genes in real time in three-dimensional space and to analyse the immediate consequences of altering the activity of regulatory factors. Of these, those capable of inter-connecting DNAs or of translocating large distances along chromatin are of interest. Cohesin is such a factor, composed of three core subunits, a pair of Smc proteins and a kleisin subunit, that interact with each other to form a huge tripartite ring, within which it is thought chromatin fibres are entrapped. In proliferating cells, cohesin’s primary function is to connect sister chromatids during DNA replication until the onset of anaphase, possibly by virtue of co-entrapment within a single ring.  However, cohesin is present in most quiescent cells and it is becoming clear that it also regulates gene expression and recombination. This proposal has two goals: To image gene expression on polytene chromosomes and to investigate coh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improving the competitivity of european textile and clothing industry by developing new methods for upgrading of cellulosic textile materials', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The CELLU-UPGRADE project aims to:- modify cellulosic textile materials (50% of all textile materials) in order to improve their properties;- to make them dryable with reactive dyes in an environmentally friendly way;- most desirably increase the durability to household washing.In the project European market leaders of cellulosic fibre and -fabric production work closely together with leading scientific institutions in this field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Redirect Innovation to foster Positive tipping Points and prevent Lock-ins in the clean Energy transition.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The climate is approaching dangerous points of no return, yet national climate commitments are lagging. One, and possibly the only, way for a timely transition to a green economy is through positive tipping points, i.e. rapid, large and irreversible shifts towards clean energy technologies due to strategic interventions and momentum buildup above critical thresholds. The current generation of coupled climate-energy-economic models, which guide climate mitigation strategies, is highly inadequate to represent and leverage these shifts properly. Current models overestimate technological costs, underestimate feasibility concerns, and oversimplify the decision-making process.The RIPPLE project aims to challenge these limitations and advance the empirical and modelling foundations of positive tipping points. First, it explores how innovation and diffusion of key green technologies can drive costs down and enable a swift transition away from fossil fuels. Novel economic approaches are integrated into a climate-energy-economic model to comprehensively map the space of alternative non-linear transitions of key technologies and their interdependencies. Second, the project investigates material and financial feasibility concerns. It augments a climate-energy-economic model to study lock-ins due to scarcity of critical materials, insufficient funds and fragile international dependencies. Third, the project elaborates on new ways of identifying early signals of positive tipping and generating policies that respond to those signals. Interpretable machine learning is used to turn noisy techno-economic data into actionable green energy tipping interventions, while exploratory modelling highlights the trade-offs between costs, speed, feasibility, fairness and robustness to uncertainties
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Lipases and receptors as determinants of lipoprotein and energy metabolism' (1994-1998).

assistant: **Concept**

Objectives:The main topics to be addressed are:* What is the physiological role for lipoprotein lipase (LPL) and/or hepatic lipase (HL) as ligands for binding and metabolism of chylomicrons/remnants in the liver and other tissues?* Which receptors are most important for this process and what are the molecular details of the interactions?* What are the relative roles of lipolysis and particle uptake for lipid transport with chylomicrons and for partitioning of fatty acids and other lipids among tissues?* What are the molecular pathways for regulation and tissue-specific expression of the LPL and HL genes? What is the basis for the cell and tissue localisation of the enzymes? * Are lipoproteins, lipases and receptors internalised as complexes by liver and other cells?* What is the impact of genetic variation in lipase, apolipoprotein and receptor genes on lipid metabolism and cardiovascular disease?Brief description:The project will utilise a wide variety of techniques of modern biomedical research. For this, the expertise of the collaborating laboratories shall complement rather than duplicate each other. Most studies will be at the level of molecular biology, cell culture, or test tube biochemistry, but there will also be organ perfusion, animal experiments and clinical genetic studies in human populations. Reagents will be developed and shared among the collaborating laboratories, such as cDNA probes, specific antisera, constructed and/or natural mutant variants of lipases, apolipoproteins and receptors, as well as genetically engineered cells and mice.The project will be implemented through collaboration and co-ordination between independent laboratories on an equal basis. All participants have joint research projects with at least one of the other laboratories. The m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'COST at a turning point: A unique framework for pan-European ST cooperation as clear demonstration of European values', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

COST is an intergovernmental framework for cooperation in science and technology (S&T). Founded in 1971, it supports collaborative S&T networks called COST Actions – a unique cooperation instrument allowing the joint development of ideas across all scientific disciplines through trans-European networking of nationally funded research activities.A process of significant review and adaptation of COST strategies and policies has been recently giving birth to a new COST, focused on inclusiveness, societal impact, output orientation and lean implementation. A fully dedicated legal entity under the direct responsibility and guidance of the COST Member Countries, the COST Association, has been established.The main objective of the present proposal is to allow COST to continue to meet the complex challenges that characterise Europe’s research and innovation agenda and in particular to pursue four solid and societally relevant objectives:1. Join research efforts and develop common S&T programs by supporting high quality pan-European S&T networks2. Build research capacity and strengthen S&T excellence across the ERA3. Address societal questions by promoting trans-disciplinary research4. Widen participation and inclusiveness through tailored mechanisms, fostering integration across the ERA COST represents European added value as it is the sole pan-European framework fostering open and bottom-up S&T cooperation networks, driven by researchers’ needs. Its focus on excellence, openness and inclusiveness has proved a successful formula over many years.Institutional, operational and administrative levels of intervention allow COST to effectively pursue the objectives above and to fulfil its mission. The consistent and continuously improved implementation of COST, already proved success
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High-order two-phase flow modelling' in the context of a Horizon 2020 call.

assistant: **Objectives**

Flows of two immiscible fluids separated by an interface, referred to as ""two-phase flows"", are ubiquitous in nature and central to many engineering applications. They contribute to the underlying principles and processes of a vast range of key sectors such as energy, transportation, manufacturing, and healthcare, and are relevant to the study of climate-change and disease-spreading. Most important to Europe's current challenges, the study of two-phase flows is instrumental in achieving the ""European Green Deal"" objective of reaching carbon-neutrality by 2050. Yet, despite their clear significance, our understanding of two-phase flows remains limited. Recently, computer simulations have become viable alternatives to experiments for their study, but they are still limited in terms of their flexibility, efficiency, and accuracy.The research programme proposed for this fellowship will provide a paradigm shift in the way two-phase flows can be simulated and therefore studied, with the development of the first high-order numerical framework for the accurate solution of their evolution in complex three-dimensional flow domains. This will entail increasing the order of representation of the local numerical approximations of the interface between the two phases, from linear to quadratic. This enhancement will in turn allow the development of high-order numerical schemes for the transport of this interface, and the estimation of the surface-tension force acting on it. These highly accurate schemes will be released to the research community in an open-source library. Not only will this enable the design of the next generation of low-emission energy-conversion technologies, which are crucially needed to reach Europe's environmental targets, but this will also yield substantial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced cell Imaging approaches in developmental biology' (CELLIMAGE) targeting Sixth Framework.

assistant: **Abstract**

Recently, advances in modern imaging techniques, in combination with the availability of genetic tools has set the stage for detailed studies at the single cell level. Our experience has been that mechanisms underlying developmental processes are conserved in organisms ranging from nematodes, insects, mice and man. In this ToK we plan to join our efforts, approaches (molecular, cellular, developmental, evolutionary), know-how in various model-systems (nematodes, insects, mice) to gain insight aspects of their development.Our group (part of the Developmental and Functional Biology group of the IMBB) consists of principal investigators that are leaders in their field in Europe and whose laboratories have provided training to many researchers from Greece and abroad. We have joined our efforts to move our research forward through the development of a new competence of advanced imaging in live organisms; we consider this expertise essential and timely as it will provide us with a leading, competitive edge towards groups in the US and Japan. The need for this competence has stemmed from our training activities as part of the Greek Microscopy Network and by the realization that all of our groups - and the host institute as a whole- would collectively benefit tremendously from the establishment of live imaging techniques, an expertise lacking in our country altogether.Work towards developing and applying the new competence will be distributed among the following directions:a) mapping patterns of cell division, movement and differentiation in the growth zone of insects,b) monitoring Notch signalling in Drosophila and other insects,c) monitoring migrations in the mammalian central nervous system,d) studying the role of mammalian adhesion molecules in the nematode ande) identifyin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Marie Curie team on exchange processes in the land surface - Atmosphere System'.

assistant: **Innovation**

The terrestrial biosphere had and has a major influence on the development of contemporary atmospheric conditions through a variety of biogeochemical feedbacks. But human activities have altered the evolved synergies in the surface-atmosphere system and in creasing evidence for human impact entails predictions of the future environment to be the basis for environmental policy.Still, important interactive processes underlying surface-atmosphere exchange are understood only imperfectly and the predictions remain highly uncertain. The MCT-ELSA will address some of the fundamental gaps in our understanding of the processes underlying trace gas and aerosol fluxes, and their interactions with atmospheric properties.An international team of young scientists, integrated into the GeoBiosphere Science Centre at Lund University, will be investigating through corresponding field and modelling studies the biogenic reactive organic carbon compound (RCC) and aerosol fluxes in ecosystems of the northern latitudes. In the northern latitudes a significant amount of carbon is stored in the biosphere - increasing temperature and/or precipitation may trigger feedbacks in the carbon cycle, and its interactions with reactive trace gas chemistry and climate.RC C play an important role in surface-atmosphere feedback loops: affecting the atmospheric CH4 growth rate via their effect on the hydroxyl radical concentration, contributing to the formation of secondary organic aerosols, and being a significant fraction o f the net carbon budget in many ecosystems. Since CO2, CH4 and aerosols influence the atmosphere's radiative balance there is a clear link betweenRCC emission and climate. RCC emissions are furthermore very sensitive to land cover change but projected emission changes in an evolving ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of solid state NMR methods at 100 kHz magic angle spinning frequency for the study of internal protein dynamics and the application to membrane proteins' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This proposal concerns the development of new solid-state NMR methods using proton detection under Magic Angle Spinning (MAS) with frequencies up to 100 kHz. The 100 kHz MAS probe head is a prototype and will allow significant gains in sensitivity by scaling down the 1H-1H dipolar coupling interaction and resulting in narrow proton line width down to 10-20 Hz. Small quantities of protein samples in the range of 0.3 to 0.5 mg allow a signal-to noise ratio that exceeds that of tens of mg in a bigger rotor at lower MAS frequency.A focus of this proposal is the development and optimization of methods to reliably determine backbone dynamics in the solid state under 100 kHz MAS condition, based on 15N R1 and R1ρ relaxation rates as well as transverse 15N CSA/ NH dipolar cross-correlated relaxation rates and NH dipolar couplings that are sensitive up to the microsecond time scale. The experimental analysis will be supported by spin dynamics simulations. 15N T2 relaxation measurements remain a challenging task, as significant differences between bulk T2 measurements using a spin-echo sequence and T1ρ measurements show. We want to compare those measurements at 100 kHz MAS and rationalize systematic differences by spin dynamics simulations.Second, bulk T2 decay times will be estimated for different in- and anti-phase coherences, present in higher-dimensional backbone spectral assignment experiments. Scalar coupling-based INEPT and CP-based polarization transfers will be compared in terms of efficiency. Aim is to minimize loss of magnetization during transfer steps with unfavorable T2 decay properties or insufficient dipolar transfer efficiency and to design an optimized set of experiments for backbone assignment at fast MAS.Methods will be developed on the small protein ubiquitin