RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Alternative Splicing Codes for Synaptic Specificity' in the context of a Horizon 2020 call.

assistant: **Objectives**

Neuronal networks represent an impressive example of highly organized complex systems. Sperry postulated that selective neuronal connectivity is achieved by chemoaffinity labels. Several such labels for axon guidance and topographic mapping have been defined. However, until recently, molecules that direct the recognition of synaptic partners and functional specification of synapses have remained obscure.Chemoaffinity tags are envisioned to provide a recognition code that would encompass the recognition of self versus non-self, recognition of sister cells, and recognition of appropriate and inappropriate synaptic partners.  Key parameters that determine the function of recognition systems are the diversity (number of independently recognizable tags), the repertoires of recognition tags in a cell population, and the contribution of tags to selective interactions. The finite number of protein-coding genes in the human genome severely limits the genetic resources that can be employed for generating molecular diversity. In this project we will test the hypothesis that alternative splicing is a central mechanism for the amplification of molecular diversity in recognition tags and their role in synaptic specificity. We will implement novel mass-spectrometry and sequencing methods to define molecular diversity of a highly diversified receptor family in mice. We will unravel the logic of receptor repertoires across cell populations and test the importance of cell type-specific alternative splicing programs for synaptic specificity. The focus of this project on cell-type specific alternative splicing advances a new dimension in neuronal transcriptomics. Discoveries and technical innovations made in this work should be applicable to molecular studies of recognition events in any s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'De-Centering Eighteenth-Century Political Economy: Rethinking Growth, Wealth and Welfare in the Swedish Empire' (DEPE).

assistant: **Concept**

The project reassesses the early history of European political economy. Historians of political economy have traditionally concentrated on the genesis of modern economics, tracing the emergence of economic models, methods and ideas that are today recognized as 'economics' through 'classical political economy', neo-classicism and on to the present.This new departure treats political economy as a discourse oriented to the improvement of conditions for human life and, as such, one of the Enlightenments key contributions to Western thought. However, any direct association of Enlightenment discourse with political economy requires qualification. Therefore, this project explores a very extensive contemporary literature about growth, wealth and welfare that has not fitted easily into the conventional retrospective history. Instead of converting past arguments into modern arguments about methods and models, the project investigates eighteenth-century political economy in terms of practical concerns, as measures and policies for betterment and improvement. Only in this way we can reconstruct what political economy meant to its contemporaries in the early modern period. The Swedish empire  considered by contemporaries as the stronghold of 'oeconomia'  functions as the primary case study, but is constantly compared with other cases, broadening the applicability of the findings. The aim of the project is to study the ways in which the key concepts of improvement  wealth, growth and welfare  were articulated in the main sites of discursive production: the University, the Diet, local and colonial governments, and academic journals. The study of the five institutions is based on the hypothesis that in each of them activities were directed towards improving the organisation of state an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Crimean-Congo Haemorrhagic Fever Vaccine' (CCHFVaccine), addressing dissemination and exploitation.

assistant: **Impact**

Natural epidemics and outbreaks of emerging viral epidemics are growing problems internationally. The general aim of the CCHFVaccine project is to develop and deliver a vaccine, which can significantly increase our capacity to control the situation of Crimean Congo Haemorrhagic fever (CCHF) disease on a global basis. The proposed work program on CCHF virus aims to build a multidisciplinary research network, able to deliver vaccine candidates, methods and procedures eligible for clinical trials, with a special focus on prevention. Thanks to the background, unique facilities and tools available among the consortium participants, CCHFVaccine will deliver tools for countering the threat of this infection in Europe and endemic areas of the world. This work program will attempt to fill gaps in CCHFV virus research on immunology and vaccinology. To achieve this overall aim, an intensive work plan will be put in place with the following specific objectives: i) to produce vaccine candidates, ii) to bring several unique animal models into front line vaccine research, iii) to validate and bring the most promising vaccine candidates to clinical trials, iv) to ensure that an immune mediated protection is adequately understood, v) to perform clinical trials at Phase I and ensure a strategy for the effective deployment and utilization in resource-poor countries, and vi) to link this project to public health bodies, NGOs and vaccine companies. The proposed CCHFVaccine project will succeed in bringing together selected competitive advantages such as: operating capacity with appropriate facilities (state-of-the-art BSL-4s) and the only animal BSL-4  -with capacity to challenge domestic animals in Europe, highly experienced researchers in the development and evaluation of vaccine candidat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enlisting synthetic fungal-bacterial consortia to produce multi-cellular mycelium-based ELMs with computational capability' under Horizon Europe.

assistant: **Concept**

Fungateria addresses a development gap in mycelium-based ELMs by developing a portfolio of ELMs that are composed of a synthetic co-cultivation consortium of a filamentous fungus and a bacterial strain. Sensing and adaptive growth of the fungal hyphae are exploited to develop an autonomous bottom-up and scalable manufacturing technology called Growth Composing (GC) that enables an engineered morphogenesis of mycelium materials using robotically controlled spray nozzles that generate local air, gas or aerosol flows steering hyphal growth. In addition, bioprinting is used to deposit inocula of the engineered bacterial strain in specific patterns and at specific times throughout the production process. Various ELM products are developed, ranging from consumer goods to applications in the environmental and construction sector, which become active through environmental cues of light, temperature and chemical attractants. To this end, synthetic biology engineering will be implemented to use the bacterial strain as a chassis for sensor-containing genetic circuits that render advanced functionalities to the ELM throughout its life cycle, either through direct activity or by influencing growth and morphology of the fungal partner. ELM activity is verified with probes that reveal bio-electric signaling in the materials - providing additional dimensions of control, monitoring, functionality and exploitation as actively computing devices. When no longer needed or having reached the end of their productive life, kill switches are activated either by human-controlled environmental triggers or triggers of the system itself, thereby causing the ELM to fully and quickly degrade without causing any negative environmental impact. Throughout the Fungateria project, a societal dialogue will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Flow Controlled Prosthetic Heart Valves' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Prosthetic Heart Valves (HV), both biological (BHV) and mechanical (MHV), have improved the survival rate and the quality of life of valvular heart-disease patients over the last six decades. While BHVs, taken from animal tissue, show improved hemodynamics, their durability is limited, whereas MHVs can last a patient's entire lifetime but require lifetime anticoagulation medication to reduce thrombotic complications. Future Polymeric HVs (PHV) hold the potential for enhanced durability compared to BHVs, while potentially avoiding the necessity for anticoagulation therapy that MHVs demand. However, the problem of flow-related thrombosis in PHVs remains a critical challenge.  Generally, flow-related thrombosis complications can be avoided by altering the flow field around the PHV, such as reducing vortices and circulatory hemodynamic structures as well as decreasing shear stresses which can lead to platelet activation. Inspired by passive flow control in nature and in the aerodynamics industry, where manipulation of fluid flow via a small configuration change provides large engineering benefits in swimming or flying, we aim to use a flow control strategy to optimize blood flow through PHVs. More specifically, in StreamlineValve, we present a new, patented, PHV that is designed to alter the flow field around the valve in a manner that reduces the primary factors contributing to coagulation on PHVs. We have already successfully demonstrated this concept in vitro in a modified MHV. In this PoC, we propose to extend this to the future of prosthetic valves via a flow controlled PHV that can be implanted via a simple transcatheter procedure avoiding undesired surgical procedures. Altogether, StreamlineValve represents a paradigm shift in the realm of prosthetic HVs, offering th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Middle East Neolithic Transition: Integrated Community Approaches', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Our world is marked by ‘disruption’, major re-orderings of society through changing circumstances, including abrupt climate change, impacting on social and economic life. What lessons can we learn from the prehistoric past about disruption, and human engagement with it? One of the first global disruptions faced by human societies was the Neolithic transition from mobile forager-hunter to settled farmer-herder in the Epi-Palaeolithic and Early Neolithic periods of the Middle East, 17,000-7000 BCE. Human communities worked through this disruption, including climate change, to enable complex societies to thrive and to form the basis for later cities, empires and civilisations. In this project, I will address key ‘Grand Challenges’ for archaeology including human responses to climate change, and societal transformation and resilience.I will lead an inter-disciplinary team in investigating the Early Neolithic transition in a greatly under-researched region, the eastern Fertile Crescent of western Iran and eastern Iraq, a core zone for early developments, including domestication of animals and crops such as goat and barley. From this zone, early farmers disseminated herding and cultivation practices across Iran into Central and South Asia and Transcaucasia. But as yet we know little about the early stages in the development of farming life-ways in the eastern Fertile Crescent, because this upland area of the Zagros mountains in Iran and Iraq has been challenging for research teams to work in. As the only scholar directing research in both western Iran and eastern Iraq, I am in a unique position to lead this high-risk, trans-border project, on a major ancient route-way (later the Silk Road) from the highlands of Iran to the plains of Mesopotamia. I will direct a programme of s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'xLiMe – crossLingual crossMedia knowledge extraction' (2007-2013).

assistant: **Concept**

Europe is different from other large media markets such as the US or China in that information is being generated in different languages and distributed via diverse streams of localised media channels. Automatic analysis is complicated further by different content types (audio, video, text) and different channels (mainstream, social media). Thus, information can only be analysed independently for each dimension. This restricts the extractable knowledge and keeps it fragmented, which ultimately constrains the exchange of information.<br/>xLiMe proposes to extract knowledge from different media channels and languages and relate it to cross-lingual, cross-media knowledge bases. By doing this in near real-time we will provide a continuously updated and comprehensive view on knowledge diffusion across media, e.g., from European communities like Catalonia to worldwide content in English.<br/>Tools and methods developed in xLiMe will be applied in three complementary case studies and evaluated by several business clients  and up to 10mio end users . We will1.\taugment more than 250 TV channels in different languages with up-to-date information from social media and news in near real-time,2.\tmonitor brands  and the diffusion of opinions across languages and media, and3.\tanalyse online shop performance with regard to external cross-lingual, cross-media factors, like campaigns for brands and the emergence of public opinions.By combining speech recognition, natural language processing, machine learning and semantic technologies we will advance key open research problems, by1.\textracting machine-readable knowledge (entities, sentiment, events and opinions) from multilingual, multimedia and social media content and integrate it with cross-lingual, cross-media knowledge bases,2.\t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Energy Smart Livestock Farming towards Zero Fossil Fuel Consumption'.

assistant: **Innovation**

The adaptation of RES technologies and machinery and their demonstration at a large-scale on farm level, require supporting measures with respect to spatial planning, infrastructure, different business models and market organisation, trends that are not all under control from a farmers’ perspective. RES4LIVE project will fill these gaps ensuring a wider adoption of RES and energy efficiency technologies, machinery and techniques in livestock farms towards a zero-fossil fuel consumption. A great part of RES4LIVE technical work deals with the adaptation of specific technologies for both renewable energy and biofuels so that to perfectly fit livestock farming and becoming attractive in terms of cost effectiveness, operational flexibility and with low maintenance. The key technologies include PVT systems, modular heat pumps, biogas upgrading to biomethane, and tractors retrofitting to be fuelled by biomethane. Except these technologies, standard RES and other solutions are included in the integrated energy system, such as the use of PV panels, geothermal energy, and electrification of on-farm machinery.The RES4LIVE project emphasises on the demonstration of the selected technologies in 4 pilot farms in Belgium, Italy, Germany and Greece, for a duration of at least 12 months, to serve as the means of de-fossilising evidence and impact generation. The aim is to totally replace the fossil fuel consumption of certain needs in the pilot farms, proving that fossil-free-energy farming is possible to be achieved with a sustainable way. At the same time, the replicability potential is another key activity so that to prepare the commercialization process of the solutions. The overall objective is to provide advanced and cost-effective technologies to the livestock sector that ensure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Overcoming Resistance to Anti-cancer Drugs by Blocking Mutation-prone DNA Polymerases and the SOS Response' under Horizon Europe.

assistant: **Concept**

Background: A large fraction of cancer patients die because their tumors initially respond to drugs but later they evolve tolerance. Thus, resistance to diverse drugs, along with the soaring costs of new treatments, are emerging as major societal issues of the 2020s. Herein, we explore one of the most distressful examples, tolerance of lung cancer to EGFR-specific tyrosine kinase inhibitors (TKIs). Working hypothesis: In similarity to bacteria exposed to antibiotics, when cancer cells are exposed to TKIs they enlist SOS responses, which activate endogenous mutators. Hence, we will combine the relatively effective but mutagenic TKIs with drugs that disarm the mutators. This scheme will be applied on models of EGFR+ lung cancer, a disease that repeatedly evolves mutations and resistance, but eventually leaves millions of patients with no treatment choices. Specific aims: Our initial studies identified one triad of the SOS system: a sensor of cell death - GAS6, a mediator - AXL, GAS6 receptor, and a mutator - low-fidelity DNA polymerases. Remarkably, blocking AXL using an antibody irreversibly prevented relapses when combined with EGFR inhibitors. Along with establishing this triad, we will employ transcriptomics, protetomics and metabolomics to resolve parallel mutators and sensors. Likewise, we will explore alternative ways to block resistance, for example by directly targeting DNA polymerases, MYC and purine metabolism. Aiming at strategies that minimize SOS enlisting, we will explore the premise of boosting immune destruction of cancer cells.Significance: According to the current status quo, next-generation inhibitors are being applied when resistance emerges. However, this scheme does not cure, only buys time. ResistSOS offers an alternative that might eradicate resis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Eco-Epidemiological Intelligence for early Warning and response to mosquito-borne disease risk in Endemic and Emergence settings' in the context of a Horizon Europe call.

assistant: **Objectives**

Mosquito-borne diseases place a heavy burden on society, causing widespread suffering and driving poverty. They are increasing in prevalence, geographical distribution and severity, representing a growing threat worldwide. Hence, there is a need for better disease intelligence, capable of anticipating and identifying eco-epidemiological risks leading to explosive epidemics and emergence in previously unaffected areas. The basis of such intelligence stems from a deep understanding of the factors that drive disease circulation, emergence and spread. This requires insights into the complex interplay between humans, pathogen-carrying mosquitoes, pathogen reservoirs (e.g. birds), and a changing environment. The  E4Warning consortium brings together interdisciplinary, innovative, and open science to contribute to the One Health paradigm shift that is required to tackle the spread and transmission of zoonotic deadly pathogens, and harness this shift to nowcast and forecast mosquito-borne disease risk in a constantly changing and globally connected environment. Our work aims to disrupt disease transmission pathways connecting humans, mosquitoes, and birds through innovative eco-epidemiological modelling tools and intelligent digital solutions, co-designed and implemented by public health administrations. Open innovation strategies and big data tools are the cornerstone of the next-level One Health Early Warning Systems required in the face of mounting mosquito-borne disease threats.


**Keywords:** Mosquito-Borne Diseases, One Health, Citizen Science, Movement Ecology,  Spatial Statistical Modelling