RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Planning the Articulation of Spoken Utterances' in the context of a Horizon 2020 call.

assistant: **Objectives**

I address major controversies relating to the basic underpinnings of the human speech production system. These concern a) the nature of the mental representations of speech sounds (symbolic vs. spatiotemporal; phonemic vs. non-phonemic gestural), b) the goals of movement (articulatory vs. explicitly acoustic; with emergent vs. explicit surface durations), and c) the processes for planning and generating speech articulations (oscillator-based mechanisms vs. Optimal Control Theory and Lee’s Tau theory). PlanArt will offer the first systematic attempt to determine which theoretical assumptions about each of these three fundamental components are required to provide an adequate account of human speech production behaviour. This ambitious task requires a cutting-edge two-pronged approach. First, through novel experiments I will test predictions of theoretical alternatives for types of phonological representations, output goals, and planning processes. Many of these experiments are inspired by theory and techniques in the non-speech motor literature, which are new to the field of speech production. In the second prong of my research, I will provide a comparison of the articulatory outputs of computational models based on particular sets of core theoretical assumptions. This second, modelling prong will include the development of a flexible, modular platform allowing for parallel implementation, testing, and comparison of competing theoretical assumptions in terms of model outputs, as well as the development of a computational implementation of a new approach, proposed by team members Turk & Shattuck-Hufnagel (2020a) to address shortcomings in the literature. Taken together, this work will provide converging evidence for the nature of the bedrock elements and processes of spee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Evaluating mHealth technology in HIV to improve Empowerment and healthcare utilisation: Research and innovation to Generate Evidence for personalised care'.

assistant: **Concept**

EmERGE will develop a mHealth platform to enable self-management of HIV in patients with stable disease. The platform will build upon and integrate the existing mHealth solutions operated by pioneering healthcare providers in the UK and Spain and apply a rigorous co-design approach to ensure patient and clinician input to the solution. The platform will provide users with web based and mobile device applications which interface securely with relevant medical data and facilitate remote access to key healthcare providers   EATG, the European HIV patient organisation, will provide a direct and deep interaction with representative patients and clinicians from 5 EU countries. The platform and interfaces will be validated in a large study of 3900 patients using a tailored HTA process, MAST, specifically developed for the assessment of mHealth solutions including translatability as a key factor.  Based on prior work showing a high uptake rate and use of mHealth in HIV patient populations, EmERGE aims to demonstrate the benefits to patients and simultaneous increases in cost-effectiveness for healthcare providers by reducing face-to-face consultations, estimated at 6000 saved per year within this study alone. Patient reported outcomes will be agreed and used in the assessment and development of the system which also aims to increase adherence and enable frailty to be reported using mHealth technology.  Innovation will be given priority from the beginning by developing new business models of care provision, targeting key stakeholders in the EU health provider sector, including policymakers and clinicians, while eliciting demand from patients to highlight and initiate the widespread implementation and compensation of mHealth solutions within the timeframe of the project.  Guideli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'INNovative thermoplastic transformation processes to produce a flange wheel in PAEK reinforced with short fibres' (INN-PAEK).

assistant: **Concept**

INN-PAEK will face the industrial production of the PAEK-based Flange Wheel for the electrical environmental control system by applying the 5Ms injection window process developed, validated and optimised by AITIIP over the last 25 year for transferring complex metallic parts to lightweight polymeric components. The 5Ms injection window process starts Modelling the bests solution, combining i) rheological, kinematic and mechanical simulation, ii) validation (coupons and specimens) tests and iii) optimisation algorithms to select the optimal Material formulation and its transformation process as well as the Mould geometry and the required innovations. In INN-PAEK, this process will be also based on the capacity of the additive manufacturing technologies to produce complex moulds that will modify its geometry during the transformation process to get properly adapted to complex geometries. Finally, the 5Ms injection window process includes destructive (mainly mechanical) and non-destructive (tomography) tests to check the right Manufacturing of the polymeric part, allowing to implement the required modifications in the mould and feeding the Machine learning phase, based on optimisation algorithms generated in previous research and innovation projects. The machine learning phase will also consider the information captured from the technician experience, the dedicated in process sensors (rheological sprue) implemented in the injection machine and the LCA and LCC analysis of the final parts. This process has been already successfully used by AITIIP with complex parts for automotive, urban furniture or medical applications among others. INN-PAEK will demonstrate the production of flange wheel with a cost reduction by 30%, a weight reduction by 40% that implies a CO2 emissions r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Study of Cohorts for Air Pollution Effects' (ESCAPE), addressing dissemination and exploitation.

assistant: **Impact**

European policy making is hampered by considerable uncertainty about the magnitude and nature of the impacts of long term exposure to air pollution on human health. ESCAPE is a collaboration of more than 30 European cohort studies including some 900,000 subjects. It is aimed at quantifying health impacts of air pollution and at reducing uncertainty. ESCAPE will also test new hypotheses on specific health effects of air pollution. ESCAPE will focus on effects of within-city, within-area and within-country contrasts in air pollution, and so will enable Europe to remain at the cutting edge worldwide for further development and application of methods which have been largely pioneered here. ESCAPE will make measurements of airborne particulate matter and nitrogen oxides in selected regions in Europe. It will measure the chemical composition of the collected particles and it will store samples for future chemical and toxicological analyses. Escape will focus on four categories of cohort studies: 1. Pregnancy outcome and birth cohort studies; 2. Studies on respiratory disease in adults; 3. Studies on cardiovascular disease in adults; 4. Studies on cancer incidence and mortality. ESCAPE responds to a specific FP7 call for a large collaborative project in the Environment and Health program. The call asks for research within existing cohorts among children as well as elderly adults as sensitive groups, and it asks to consider the role of other environmental exposures such as noise, and of biomarkers and gene-environment interactions. Whereas ESCAPE will focus, as requested, on air pollution and to a lesser extent traffic noise exposures, studies have been included which contain a wealth of data on other exposures (e.g., drinking water contaminants), on biomarkers and on genetics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'In vitro reconstitution of the initiation of mitophagosome formation' (Mitophagy).

assistant: **Concept**

Mitophagy is a tightly controlled process in which dysfunctional mitochondria are isolated and selectively degraded by autophagy. Many cell types critically rely on this pathway and mitophagy is therefore essential to life. For instance, egg fertilization or red blood cell development would not be possible without mitophagy. The importance of mitophagy is further underscored by its many links to human disease, most evident by mutations in the protein kinase PINK1 and the E3 ubiquitin ligase Parkin, causing autosomal recessive Parkinson’s disease. While most factors required for mitophagy are known, a major outstanding question is: how do the different factors come together to produce a mitophagosome? As the process comprises many different factors, each with a unique role, this is a challenging scientific question to address. The goal of this project is to gain insight into this process, using biochemical reconstitution, to elucidate how more than 15 different factors work together to initiate the formation of a mitophagosome. A unique aspect about our approach is that it not only allows to elucidate how mitophagosome formation is initiated, it could also reveal additional layers of fine-tuning, for instance also explaining how mitophagy is prevented from being initiated too early. This project may therefore lead to a major step forward, establishing a coherent framework of how mitophagosome formation is organized. Moreover, it could lead to new avenues for treating devastating neurodegenerative diseases like Parkinson.


**Keywords:** Mitophagy, PINK1, PARKIN, selective autophagy, OPTN, NDP52, TBK1, LC3, in vitro reconstitution, mitochondria, mitochondrial homeostasis, Parkinson's disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Environmental Monitoring Warning & Emergency System' in the context of a Fourth Framework call.

assistant: **Objectives**

ENVISYS' primary objective is to create a complete system for the early detection of oil-spills, the monitoring of sea pollution due to oil spills, and the provision of support to the responsible public authorities during clean-up operations. Other objectives include investigating the feasibility and cost-effectiveness of applying the ENVISYS system in the detection of other emergencies (e.g. forest fires and floods), and an overall evaluation of the proposed techniques. A demonstrator will be built integrating and developing existing remote sensing techniques, communication tools, GIS, databases and multimedia tools; its applicability will be tested and verified.The main results of the project include demonstrations of the system at three different sites and an overall evaluation and assessment in the user-oriented context. This will be followed by dissemination of related information, in the first instance to the Envisys User Reference Group, and more widely to an international community directly or indirectly associated with this type of work.ENVISYS will provide a management, monitoring and control system for various Public Authorities in Europe concerned with identification and alerts on oil spills. It will indicate the applicability of such a system to a harmonised emergency system for other natural disasters such as forest fires and floods.Major Validation SitesCyclades Regional Development Company, Notio Aigaio, GRSistemas de Seguimento Informatico S.L., Valencia, ESSociedad Estatal de Sasemar Salvamento y Seguridad Maritimo, Galicia-Andalucia, ESNorsk Regnensentralen, NO UsersThe users involved are, AN.ET.KY - Affiliate of the Prefecture of Cyclades in Greece, INDI - marine environment information provider in Spain, and SASEMAR, the Spanish Maritime Salvage and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-Omics-based BIomarker Signatures of dietary Carbohydrates qUalITy and risk of chronic diseaseS.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The prevalence of type 2 diabetes mellitus (T2D), cardiovascular disease (CVD), and dementia is rapidly increasing worldwide and is therefore a major public health concern. Carbohydrate intake (40-80%) represents the main source of energy in most populations and the quality more than the quantity has a large effect on health. Recently, a “carbohydrate quality index” (CQI) emerged as a exposure that captures the combined and potentially synergistic effects of dietary glycemic index and intakes of total fiber, whole grains, and liquid or solid carbohydrates in a comprehensive manner. A high dietary carbohydrate quality assessed by the CQI has been associated with lower risk of T2D, CVD, and intermediate risk factors. However, the precise mechanisms of the associated beneficial effects offered by high CQI scores remain unresolved partially due to the lack of accurate biomarkers reflecting their exposure and the minimal information available on how CQI impacts the gut microbiota. The main objective of BISCUITS is to identify multi-omics signatures of dietary carbohydrate quality assessed by the CQI and evaluate their associations with the risk of chronic diseases in adult populations. We will integrate metabolomics and microbiota datasets using novel machine learning algorithms to identify combined panels of metabolites and microbial species reflecting the exposure to high CQI scores. We will also investigate the potential associations of these signatures with the risk of T2D, CVD, and dementia in two populations. Similar studies to this are not available in the literature and have the potential to discover novel biomarkers of CQI exposure and map biochemical mechanisms explaining the complex relationship between CQI and these diseases. This could open new avenues for the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Electronic Neuropharmacology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

As the population ages, neurodegenerative diseases (ND) will have a devastating impact on individuals and society. Despite enormous research efforts there is still no cure for these diseases, only care! The origin of ND is hugely complex, spanning from the molecular level to systemic processes, causing malfunctioning of signalling in the central nervous system (CNS). This signalling includes the coupled processing of biochemical and electrical signals, however current approaches for symptomatic- and disease modifying treatments are all based on biochemical approaches, alone.Organic bioelectronics has arisen as a promising technology providing signal translation, as sensors and modulators, across the biology-technology interface; especially, it has proven unique in neuronal applications. There is great opportunity with organic bioelectronics since it can complement biochemical pharmacology to enable a twinned electric-biochemical therapy for ND and neurological disorders. However, this technology is traditionally manufactured on stand-alone substrates. Even though organic bioelectronics has been manufactured on flexible and soft carriers in the past, current technology consume space and volume, that when applied to CNS, rule out close proximity and amalgamation between the bioelectronics technology and CNS components – features that are needed in order to reach high therapeutic efficacy.e-NeuroPharma includes development of innovative organic bioelectronics, that can be in-vivo-manufactured within the brain. The overall aim is to evaluate and develop electrodes, delivery devices and sensors that enable a twinned biochemical-electric therapy approach to combat ND and other neurological disorders. e-NeuroPharma will focus on the development of materials that can cross the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Take-up of Essential Information Society Technologies ? Technologies for Medical Applications' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This project constitutes a framework in which 6 activities regarding concurrent systems applied to Medicine will be developed. Under this framework management and dissemination will be performed centralised to increase effectiveness. The 19 centres participating in this project will produce the following activities: DEAF, a system for distance hearing aids fitting. CREAM, a component based and real-time embeddable X-Ray image server. ISAC, a real-time processing system for assessing the intra-operative stability of orthopaedic implants. ADAM, a system for automatic data analysis for melanoma early detection. DISMEDI, a DICOM remote computer aided image diagnosis server for medical image processing. IONIC, a complete interworking system over networks of devices in intensitive care units.The cluster will give a corporative image of all the projects for the dissemination of results and will provide efficient management and monitorising.OBJECTIVESAs a cluster, the objectives are the following:- To improve the efficiency on the management and review of the activities;- To improve the dissemination of the results by:- Providing with a European Dimension;- Providing with the experience of the HPCN-TTN Network;- Assessing the quality of the material (homogeneity, message, proof reading, target, layout);- To increase the impact of the results of the activities.As individual projects, to deploy the five trials and one best-practice described in the workplan. The activities are focused on improving:- Medical Diagnosis, with image processing remote servers, systems for early detection of special patologies and components for improving the connection of systems and the migration to digital radiology;- Therapy, with aids for distance hearing fitting.- Surgery planning, focused on ort
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Coat assembly and membrane remodelling: understanding regulation of protein secretion'.

assistant: **Objectives**

Eukaryotic cells are organised in membrane-bound compartments, which have defined chemical identities and carry out specific essential functions. Exchange of material between these compartments is necessary to maintain cell functionality, and is achieved in a highly specific and regulated manner by vesicular transport. To mediate protein trafficking, coat complexes assemble on membranes and couple bilayer deformation with cargo capture into transport carriers. How coat assembly can deliver the flexibility necessary to accommodate a wide variety of cargo proteins, and how the process can be regulated, are outstanding questions in the field. This is exemplified by the COPII coat, which mediates export from the ER of about a third of newly synthesized proteins. COPII assembles into two concentric layers and can form transport carriers of a variety of shapes and sizes, including tubules and spherical vesicles. This is important for export of large cargoes and is a process targeted by cargo-specific regulatory factors. The aim of this project proposal is to shed light on the molecular interactions between coat components, and understand their role in determination of coat architecture and membrane shape. We will use a combination of structural and functional approaches to characterise COPII coat assembly, and its relationship with membranes in systems of increasing complexity, ranging from in vitro reconstitutions to cells. In particular, we will use cryo-electron tomography and subtomogram averaging to understand the architecture of the coat layers in these systems. These are fast-developing techniques that uniquely target complex structures while achieving high resolutions. With my lab at the forefront of current advances, we are perfectly placed to obtain a complete view