RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Automotive Big Data Marketplace for Innovative Cross-sectorial Vehicle Data Services', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Inside today's vehicles ~4000 CAN-Bus signals/sec are processed in comparison to very few signals in smart phones and alike. This large amount of continuously gathered vehicle data represents major big data business potentials, not only for the automotive industry but in particular for cross-sectorial industries with interdisciplinary applications. With today's proprietary approaches focusing on bringing services into vehicles and the applied ignorance of customer privacy concerns, this major business potential is still locked because the automotive industry was not yet able to establish an open service ecosystem equivalent to the ones in the smart phone industry.The core intention of the AutoMat project is to innovate an open ecosystem for Vehicle Big Data, materializing in the form of a cross-border Vehicle Big Data Marketplace that leverages currently unused information gathered from connected vehicles. The interface to the marketplace is derived from a Common Vehicle Information Model that makes mined and anonymous vehicle data from various OEMs accessible to cross-sectorial service providers. With the huge amount of volatile data from vehicles, the AutoMat ecosystem heavily builds upon current trends in Big Data. Exemplary service scenarios, driven by service providers dedicated to generate concrete businesses from the AutoMat ecosystem, are developed in the context of meteorological data based hyper local and extended innovative enterprise service domains.By defining an open value chain, the proposed AutoMat ecosystem enables and stimulates parties from different sectors to focus on their core businesses and to excel collaboration with other partners. AutoMat therefore may serve as incubator for new business opportunities strengthening Europe's position as provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Elevated Concentration photovoltaic solar energy generator and fully automated machinery for high throughput manufacturing and testing' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Today most of HCPV (High Concentration PhotoVoltaic) generators are built with refractive lenses. A few companies have developed efficient solutions and set up manufacturing lines for these kind of products, but there aren’t effective reflective optics HCPV systems in Europe.ECOSOLE regards the realization and demonstration of an innovative HCPV generator made of:• New high efficiency,very high concentration, photovoltaic modules made of high acceptance refractive optics with high performance coatings, new III-V spectrum tuned quantic effect multi-junction solar cells and novel heat and humidity management systems.• New high efficiency DC-AC module converters with radio communication and specific fast MPPT algorithms.• A low cost, high precision solar tracker with improved reliability moving parts and lightweight structures.The project will focus on the integrated design of the new HCPV generator and on the study and demonstration of new methods for its large scale low cost manufacturing. The project will also focus on the study and testing of the generator’s reliability. The generators will be tested in outdoor conditions in different sites and a system performance model will be developed.The product’s cost and performance are strictly affected by the manufacturing methods, and the product’s market competitiveness is dependent upon the manufacturing method and its automation level. The manufacturing process will be capable of very high production rates as high as 1 HCPV module per minute to guarantee the high throughput necessary to drop the manufacturing's cost.The new HCPV generator and its manufacturing methods will enable the setup of large production scale processes that will make it possible to deploy the new generators for the realization of huge photovoltaic po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Single-Photon Light Sources for Quantum Technologies'.

assistant: **Concept**

Despite monumental advancements in IT, our computers remain very inefficient in solving many of the most crucial and complex challenges we are facing. This is the vision of Quantum Technologies and one of the most promising platforms is based on single quantum particles of light, i.e., single photons. So far, high-fidelity single-photon sources were not commercially available until Sparrow Quantum (SQ) introduced its beta-version single-photon chip – the world’s first commercially available single-photon light source. Our technology builds on world-leading in-house expertise on quantum optics and nanofabrication, and exclusively licensed patents from NBI in Copenhagen. QTOOL objective is fine-tuning and demonstrating a set of key single-photon products. They will enable researchers in Photonic Quantum Technologies to carry out their research in faster, cheaper, and better ways, and enable technologies and components that are impossible with any currently available light sources.


**Keywords:** Quantum photonics,Quantum computing,Pharmaceutical quantum simulation,Quantum Simulators,Quantum cryptography,Integrated photonics,Quantum technologies,Single-photon sources,Quantum sensing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Opt-electronic integration for 100 Gigabit Ethernet Optical Networks', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This project addresses the challenges of very high bit rate opto-electronics transceivers suitable for 100 Giga Ethernet type applications. Observation of the steady improvement in Silicon CMOS performances, as well as the increase in data traffic projections, are incentives for this evolution, expected to become an industrial reality in the first part of the next decade.In this project, the focus is on the demonstration of the highest speed components that integrate the optoelectronic transducers (light modulator and photodiode) with their driving electronics (driver and preamplifier respectively). Really new optoelectronics components will be developed based on designs experienced for lower bit rates (40 and 80 Gbit/s) and their characteristics will be optimised in order to match specifications that will be derived from systems considerations. As important as the optoelectronic devices characteristics themselves is the Opto-Electronic Integrated Circuit technology that will be used for the transceivers. Two parallel routes will be followed in this project for the transmitter and receiver : while the monolithic integration is chosen for the later, with its associated advantages of lower added parasitics and shorter interconnections than conventional approaches, a flip-chip integration is to be used for the former, to benefit from optimised technologies for both the Electro-absorption Modulated Laser and the electronic driver and to better accommodate thermal issues. Guidelines for this production of integrated devices as well as for the components packaging will be given by a supporting Electro-Magnetic simulation activity. This project will be completed by an assessment of the fabricated components with respect to the projected application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of a generic surface plasmon resonance optical chemical sensor system using specific receptors for monitoring phenols and related drugs, herbicides and allergens', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Foreseen ResultsFinally, prototype instruments will be made and tested with a view to producing both practical personal monitors and more sophisticated multi-purpose measurement instruments. The program will also take advantage of the unique opportunity afforded by the Chemistry Department at the University of Kent to offer young CCE/NIS research students the chance to work in a community of many other young European students. The Department has been at the forefront of ECTS and ERASMUS programmes in chemistry, and has typically 40 exchange students from EU countries each year. The opportunity for young CCE/NIS students to become part of this network and experience the standards, attitudes and aspirations of their counterparts in other parts of Europe has an important role in stabilising RTD potential.This proposal addresses section 8.3 Measurement and Testing for the needs of society in Health and Safety, by using novel optical methods of chemical sensing in association with designed molecular receptors. The project will use selective organic reagents immobilised on gold films, with surface plasmon resonance (SPR) as the optical transduction method, to develop a standard instrument configuration capable of application to a wide range of chemical measurement tasks. This will significantly improve comparability of measurement methods and reference exposure data for occupational health and safety. The key to effective use of SPR as a generic yet selective chemical sensing method is the synthesis of specific receptor molecules which can easily be immobilised on the surface of metal films in well-defined orientations which make available their receptor sites to analytes in the surrounding medium. This proposal combines a highly innovative method of SPR detection using a Sch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NOVEL APPROACHES TO PATHOGENESIS, DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES BASED ON NEW INSIGHTS INTO THYMUS-DEPENDENT SELF-TOLERANCE' in the context of a Sixth Framework call.

assistant: **Objectives**

Autoimmune diseases are a significant burden for the quality of life and health care cost. Despite intense research efforts, the mechanisms underlying the development of autoimmune diseases are still largely obscure. This obvious ignorance explains why the current treatment of these chronic diseases remains inadequate and is associated with severe side effects. Here we propose an original and new approach to tackle this problem.Our approach is mainly based on the major biological function of the thymus, i.e. to ensure the generation of a diverse repertoire of T cell receptors that are self-tolerant.The thymus achieves this goal by using two complementary mechanisms: a) apoptotic deletion and developmental arrest of T cells bearing a receptor (TCR) with high affinity for self-antigens presented by major histocompatibility complex (MHC) proteins expressed by thymic epithelial and dendritic cells, and b) generation of self-antigen specific regulatory T cells. The escape from central self-tolerance now appears to play a prominent role in the development of autoimmune diseases.Six workpackages will achieve the objectives of this proposal:1. Intrathymic promiscuous gene expression and self-peptide tolerogenic therapy.2. Preclinical studies of the autoimmune regulator (AIRE) in gene therapy.3. Interest of anti-Coxsackievirus B4 vaccination for prevention of type 1 diabetes.4. Exploration of a new T cell pathway governing autoimmunity and allergy.5. Development, function and therapeutic utility of regulatory T cells in autoimmune diseases and asthma.6. Evaluation of thymic epithelial stem cell therapeutic potential.This ambitious research project will lead to new insights into disease mechanisms, and will concurrently provide a unique platform for innovative diagnostics and for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Marrying Ontology and Software Technology'.

assistant: **Innovation**

MOST will improve software engineering by leveraging ontology and reasoning technology. To reach this goal, a seamless integration of ontology technology into model-driven software development (MDSD) will be realized, resulting in ontology-driven software development (ODSD). This concerns the integration of all involved artefacts (ontology and modelling languages, models, tools), as well as the development processes (process and reasoning guidance, traceability of models).The MOST artefact integration technology will allow for managing software development and ontology-based validation and knowledge management in an integrated platform. First, integration will address modelling languages. To be able to query and transform integrated models, a unified view of metamodels must be provided. Second, ontologies and models will be integrated so that ontologies can be used in models, and vice versa. For the first time, MOST will enable integrated model chains, transformations between models either consisting of ontologies or system models. Third, ontology-based queries will be integrated on the level of MDA transformations. Querying will support the developer to fulfil requirements and address modelling decisions. The MOST technology will considerably generalize existing infrastructures, such as the ODM, to address the issues at hand.The MOST ontology-driven, model-aware software process will be guided by process guidance ontologies that formalize the rules, conditions and actions a software engineer has to conduct in specific situations. These ontologies will formalize knowledge about software processes and help their guided execution. To be able to guide software engineers through the development of integrated model chains, traceability information will also be provided for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and validation of a framework using multiple sources of real-world data to assess the benefit-risk balance of advanced therapies in inflammatory bowel disease' (FORECAST), addressing dissemination and exploitation.

assistant: **Impact**

Assessing the benefit-risk balance of treatment is crucial in medicine to select the most appropriate treatment for patients. This process faces major challenges, how to implement evidence in real time to guide treatment choice and how to summarize efficacy and safety outcomes to patients and clinicians, while incorporating patient preferences. Inflammatory bowel diseases (IBD) affect 3 million residents in Europe. New advanced therapies have been recently approved, but in the absence of head-to-head randomized controlled trials (RCT), data are lacking to position each drug in the therapeutic management. Multiple types of real-world data (RWD) sources are available to assess the effect of treatment, but each type has its proper strengths and limitations. Linking multiple RWD sources can overcome limitations and leverage the strengths of each data source. We recently emulated clinical trials supporting the use of RWD to assess treatment effectiveness and safety in IBD.Based on the linkage of nationwide healthcare databases, electronic health records, and a prospective cohort of IBD patients, the aims of the current proposal are (i) to validate algorithms identifying IBD characteristics and outcomes in nationwide healthcare databases, (ii) to emulate head-to-head clinical trials comparing advanced therapies in IBD, (iii) to incorporate trials findings and patient preferences in a clinical decision support system for IBD patients and clinicians, whose impact will be assessed by a pragmatic RCT nested in nationwide healthcare databases.This challenging project will involve multi-disciplinary aspects, from qualitative approach to artificial intelligence, to clarify the position of each treatment in IBD and disseminate findings to patients and clinicians. Besides scientific i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Satellite-Based Remote Multi-Project Reporting and Controlling in Construction Industry' (SABARECO).

assistant: **Concept**

The project is a trial aiming for remote multi-project reporting and control in the construction industry. The problem of construction sites reporting progress to headquarters and the re-scheduling of a project with implications on other projects is difficult when the information flow is slow. Due to missing communications infrastructure at a construction site, satellite based links will be used for communication. In the headquarters, an integrated system of ERP (enterprise resource planning), PM (project management) and others is implemented. Remote sites will be able to browse and update this information using normal WWW browsers and special software clients. The consortium consists of one end-user CONSULGAL and a supplier team providing the necessary hard- and software and satellite components for the trial.The global objectives of the project are:1. to enable European construction enterprises including SMEs to increase their competitiveness in the global marketplace by deploying innovative satellite based information browsing and updating (reporting) facilities, which enhance multi-project scheduling, management and control;2. to deploy satellite based links using standard protocols to enable information sharing between world wide distributed teams, specifically for construction projects, allowing European enterprises including SMEs to overcome constraints in working methods and organization imposed by distance and time.To fulfil these two objectives, an integrated hard- and software system is specified, implemented, trialed and evaluated based on the construction enterprise end-user requirements already known but continually analysed and refined at the participating end-user sites.The project aims to enable the efficient sharing of information between team members
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Regulation of inflammatory response by extracellular ATP and P2X7 receptor signalling: through and beyond the inflammasome' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Inflammatory diseases affect over 80 million people worldwide and accompany many diseases of industrialized countries, being the majority of them infection-free conditions. There are few efficient anti-inflammatory drugs to treat chronic inflammation and thus, there is an urgent need to validate novel targets. We now know that innate immunity is the main coordinator and driver of inflammation. Recently, we and others have shown that the activation of purinergic P2X7 receptors (P2X7R) in immune cells is a novel and increasingly validated pathway to initiate inflammation through the activation of the NLRP3 inflammasome and the release of IL-1β and IL-18 cytokines. However, how NLRP3 sense P2X7R activation is not fully understood. Furthermore, extracellular ATP, the physiological P2X7R agonist, is a crucial danger signal released by injured cells, and one of the most important mediators of infection-free inflammation. We have also identified novel signalling roles for P2X7R independent on the NLRP3 inflammasome, including the release of proteases or inflammatory lipids. Therefore, P2X7R has generated increasing interest as a therapeutic target in inflammatory diseases, being drug like P2X7R antagonist in clinical trials to treat inflammatory diseases. However, it is often questioned the functionality of P2X7R in vivo, where it is thought that extracellular ATP levels are below the threshold to activate P2X7R. The overall significance of this proposal relays to elucidate how extracellular ATP controls host-defence in vivo, ultimately depicting P2X7R signalling through and beyond inflammasome activation. We foresee that our results will generate a leading innovative knowledge about in vivo extracellular ATP signalling during the host response to infection and sterile danger.