RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Francisco de Vitoria and Hugo Grotius: between objective right and subjective rights' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The project is aimed at ensuring the achievement of important scientific objectives in the framework of European research, and is strictly connected with the current debate about a Europe necessarily open to meeting the alter in the respect of unalienable rights.The research, in fact investigating the existing relationship between the objective right and the subjective right in Vitoria and Grotius, touches some nodal points of the current debate on human rights, such as the correlativity or not existing between objective rights and subjective ones. The intention of this research is to investigate how Francisco de Vitoria and Hugo Grotius's change from an idea of objective natural law to a conception of subjective natural laws came about, laws which characterise modern politics.The choice of these authors is motivated by the fact that they are both forerunners of human rights and international law. The project presented here thus favours the formation of a researcher who is asserting herself on a European and international level as a valid expert in the field of philosophical Hispanics and as historian of ideas in the field of the intricate story" of the assertion of human rights in western civilisation.The research will enable the publishing of the edition of previously unpublished university lectures by Francisco de Vitoria about the Ultimate End of Man, on the Human Acts, on Virtue. The interest of the research lies also in the fact that it will enable the achievement of the publication of a bilingual essay (Italian-English) on the theme of war and peace in Francisco de Vitoria and Hugo Grotius.The project presented here favours an important development in the formation of the applicant, in that it contributes to giving her a career a European dimension capable of goi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Evolutionary probabilistic circuit design'.

assistant: **Objectives**

Circuit design is a complex problem due to huge design space dimensions. Effective search in large complex spaces is requiring smart tools. The application of evolutionary algorithms for circuit design seems to be the most attractive approach, which allows us to obtain novel circuit solutions. Many positive results have been published. However, the choice of the best structure of evolutionary design is unclear till now. Our proposal will concentrate on leading edge evolutionary probabilistic circuit design techniques. They have recently attracted renewed interest of circuit designers because of its potentially important contribution to advanced EDA. The current project is expected to generate innovative contributions to both EDA and evolvable hardware. The project aims are an investigation of new approaches to increasing effectiveness of EDA tools. The principal research objective of the project is evolutionary circuit design by means of probabilistic evolutionary models. The novelty of our approach lies in the explicit incorporation of the probabilistic models into the circuit design. The general idea is that probabilistic models are able to accumulate design information about suitable building blocks, as for analogue circuits like phase-shifters, filters, PL L, when approaching analogue signal processing. It is expected that exploitation of evolutionary circuit design software will substantially improve circuit design. The proposal offers the potential to increase the market lead of European technology users, b y enabling them to offer better software capable of doing more effective computer aided circuit design. The market in computer aided circuit design exists and is buoyant. The evolutionary design techniques are `off-the-shelf¿ in the sense of being known and app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Scenarios for integration of bio-liquids in existing REFINERY processes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

There is a strong need to develop new biofuels production technologies that can be integrated into existing infrastructures, leading to biofuels that are cost competitive compared to existing ones and conventional fuels, with the same level of performance and a lower carbon footprint.The 4REFINERY project will develop and demonstrate up to pilot, routes to the production of next generation biofuels from more efficient primary liquefaction processes integrated with upgraded downstream (hydro)refining processes, to achieve overall increased carbon yields of >45%. The strong consortium covering the full process value chain, will identify risk-mitigation pathways for successful implementation into existing refineries, including delivering a comprehensive toolbox for interfacing with existing refinery models.4REFINERY will focus on optimal pathways for the transformation of bio-liquids from fast pyrolysis and hydrothermal liquefaction into advanced biofuels, through intermediate process steps (fractionation, stabilisation)  combined with downstream co-processes technologies at different levels of severities (temperature, hydrogen consumption, carbon yield): co-Fluid Catalytic Cracking, co-hydrodeoxygenation and  co-hydrotreating. The project will establish relations between product’s properties, the quality of renewable feedstocks and the main process parameters.The study of these combinations will allow a full understanding of the influence of feedstock and treatment processes on product characteristics, describing, analysing and providing insight into synergetic effects. Tangible results include add-ons to existing flow sheeting programs/unit model, with the objectives to analyze different scenarios for further implementation into existing archetype refineries, and to be d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Properties and Applications of the Gauge/Gravity Correspondence' (STRING) targeting Seventh Framework.

assistant: **Abstract**

This proposal is concerned with developing and exploiting the remarkable connections between many relativistic and nonrelativistic matter systems on the one hand, and gravitating systems on the other. These connections are implied by the correspondence between gauge quantum field theory and quantum gravity (the gauge/gravity correspondence ) that is a characteristic feature of string theory, which unifies gravity and Yang-Mills gauge theory in a fundamental manner. There are several interrelated objectives: (1) Strongly coupled non-gravitational systems. The aim is to make use of the gauge/gravity equivalence to further our understanding of particularly interesting matter systems that are intrinsically strongly coupled and for which there are therefore few other calculational tools available. Systems of this type include high energy collisions of heavy ions, systems exhibiting quantum criticality, such as high temperature and heavy fermion superconductors, and quarks confined within hadrons by the strong force. (2) Strongly coupled gravitational systems. The aim here is to make use of the gauge/gravity equivalence to deduce properties of gravitational systems at high curvature, starting from weakly coupled gauge theory. The aim is to study: (a) cosmological singularities and the evolution of the early universe in the big-bang era; {b) quantum properties of black holes. (3) Developing the structure of the gauge/gravity correspondence. The projects outlined above rely on further developing the geometrical structure of string theory. The proposal focuses on two crucial aspects: (a) The exact integrability of string theory in anti de Sitter space and the corresponding Yang-Mills gauge quantum field theory, which leads to powerful exact results. (b) The detailed manner in wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The inherent morphological potential of the actin cortex and the mechanics of shape control during cell division' to be submitted under Seventh Framework.

assistant: **Abstract**

The shape of animal cells is primarily determined by the cellular cortex, a cross-linked network of actin and myosin lying directly beneath the plasma membrane. Although it is increasingly clear that the study of cell mechanics is essential to understand cellular morphogenesis, the physical properties of the cortex are poorly understood. Our previous study on the mechanics of cytokinesis identified cortex tension, network turnover and cellular elasticity as key mechanical parameters controlling cell morphology. A physical description coupling cortex mechanics to cellular shape changes indicates that modulation of these three key parameters could be sufficient to induce a variety of morphological behaviors, including symmetric ingression of a contractile ring, cortex oscillations, and even asymmetric cell cleavage. The aim of this proposal is to reveal the intrinsic shape-generating potential of the cortex and to understand how this potential is used and controlled during cell division. To do so, we will first investigate how cortex tension, turnover and cell elasticity are controlled throughout division. We will test our understanding of cell shape mechanics by exploring how perturbing these properties affects the shape of the dividing cell. We will then explore whether cortical contractions can lead to asymmetric cytokinesis by attempting to induce differences in size between daughter cells by mechanical perturbations. Finally, we will use blebs separated from cells as model isolated cortices and investigate the control of shape dynamics in this simplified system. Our interdisciplinary approach will produce an integrated description of the mechanical function of the cortex in cell shape changes. More generally, I expect that this work will unveil some of the fundamenta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Eco-Smart Twist & Pop Closure System to Control Bubbles in Carbonated Beverages' to be submitted under Horizon 2020.

assistant: **Abstract**

Have you ever realised that the cap on your beer bottle cannot be recycled? If so, then you are aware of one of the key problems in the Caps and Closures carbonated beverage market: the lack of sustainability. Current closures systems for sparkling wine, beers or carbonated soft drinks are underperforming due their highly demanding features and their current linear take-make-dispose system of use. Among technical challenges in the production and expedition processes are: oxidation in humid environments (e.g. during the production of sparkling wine in the traditional méthode Champenoise), difficulty in recycling multi-material closures like metal screw caps, non-reusability features (e.g. cork closure are not reusable), and the increased costs and production downtimes due to bottle breakage caused by the high force applied to the bottle in crown corks. Thus, current systems are inefficient in terms of sensorial, technical and environmental performance and do not comply with circular economy packaging requirements.The Twist & Pop closure system is based on a unique patented mono-material design that does not compromise the sensorial neutrality, ensures the sealing of the carbonated beverages bottles and most importantly is 100% recyclable and reusable. Our innovative technology (TRL6) is the solution for the current sustainability challenges of the Caps & Closures market. We have more than 15 years of R&D trajectory and a solid ecosystem of stakeholders (e.g. Importacions Decavi, Della Toffola Group, HUSKY Injection Molding System). We have raised great interest among Spanish cava producers (Vallformosa), beer breweries (Heineken), and international players in packaging (HSK). We plan to develop our prototypes up to a market-ready solution at their facilities. We aim to b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Building a causal regulatory network of mesenchymal cells using targeted programming experiments'.

assistant: **Objectives**

Gene regulation is one of the main drivers of a cell's fate and function, but current methods that infer genome-wide regulatory networks have problems with inferring causal and/or combinatorial interactions. Pooled single-cell screening technologies, such as those developed in the host lab, now provide a powerful alternative to regulatory network inference. However, as this technology matures, data analysis is now more and more becoming the rate-limiting step in inferring causal and combinatorial regulatory networks.In this project, I will develop a combined computational and experimental workflow to infer regulatory networks. At the computational side, I will develop an algorithm that models how combinations of transcription factors affect a cell's state. The model will go beyond a ball-stick model, and investigate combinatorial logic, dosage effects, cell proliferation and cellular heterogeneity. The algorithm will also propose new combinations that may move a cell towards a fate of interest. Through multiple rounds of modelling and experimentation, I will iteratively improve our understanding of the causality and combinatorics of a regulatory network.I will validate the workflow on mesenchymal stem cells (MSCs), a cell type for which some (combinations of) transcription factors that drive its differentiation are already known, but for which a combinatorial view across lineages is still missing. I will first start with easier well-studied systems, such as adipocyte differentiation, and later in the project move on to less-studied systems such as adipocyte progenitors.By integrating experimental and computational techniques, the proposed project will provide a causal regulatory network across MSC lineages, and yield a framework to generate such a network in other syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Logical Foundations for the Future of Safe Systems Programming' under Horizon 2020.

assistant: **Concept**

A longstanding question in the design of programming languages is how to balance safety and control. C-like languages give programmers low-level control over resource management at the expense of safety, whereas Java-like languages give programmers safe high-level abstractions at the expense of control.Rust is a new language developed at Mozilla Research that marries together the low-level flexibility of modern C++ with a strong ""ownership-based"" type system guaranteeing type safety, memory safety, and data race freedom. As such, Rust has the potential to revolutionize systems programming, making it possible to build software systems that are safe by construction, without having to give up low-level control over performance.Unfortunately, none of Rust's safety claims have been formally investigated, and it is not at all clear that they hold. To rule out data races and other common programming errors, Rust's core type system prohibits the aliasing of mutable state, but this is too restrictive for implementing some low-level data structures. Consequently, Rust's standard libraries make widespread internal use of unsafe blocks, which enable them to opt out of the type system when necessary. The hope is that such unsafe code is properly encapsulated, so that Rust's language-level safety guarantees are preserved. But due to Rust's reliance on a weak memory model of concurrency, along with its bleeding-edge type system, verifying thatRust and its libraries are actually safe will require fundamental advances to the state of the art.In this project, we aim to equip Rust programmers with the first formal tools for verifying safe encapsulation of unsafe code. Any realistic languages targeting this domain in the future will encounter the same problem, so we expect our results to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Simulating coastal HydrOdynamics and particle tRansport procEsses' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Beaches are eroding at many locations around the world and, with the pending climate change (sea level rise and increased storminess in Northern Europe), coastal erosion is expected to potentially worsen. State-of-the-art practical engineering models for predicting sand and particle transport struggle with the cross-shore processes (perpendicular to the beach), and they even have difficulties predicting the sign right (offshore transport vs. onshore transport), in an experimental setting where the boundary conditions are fully known. The shortage of state-of-the-art models also means that the spreading of microplastic particles, which are increasingly polluting the oceans cannot be predicted accurately. As a result, the future shape of the world’s coastal profiles and the fate of microplastic particles in the coastal region are largely unknown. SHORE aims to bridge this knowledge and competence gap and develop the first model capable of accurately simulating both on and offshore transport of sediments and microplastic particles without case-specific calibration.The new model will (1) break from central assumptions used in existing state-of-the-art models, (2) utilize integrated rather than local quantities and (3) include additional factors known to govern the physics in the complex region around the shoreline. The development of the novel model will be made possible by gathering a novel experimental database containing measurements across a wide range of scenarios and utilizing more advanced numerical models. These advanced models are too computationally heavy to be used to study morphology, but due to recent breakthroughs by my colleagues and I they can be used to study the governing processes. The model developed within SHORE will subsequently be used to answer quest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structural and functional characterization of large viral and human non-coding RNA motifs involved in HIV infection' (3DviralRNA) under Horizon 2020.

assistant: **Objectives**

HIV infections cause 1.2Mi deaths/year worldwide at steadily-increasing rates, partly because of antiretroviral resistance and the impossibility of eradicating latent viruses. To expand our understanding of HIV pathogenesis, we need to unravel all molecular mechanisms involved in HIV progression. Large viral and human RNAs are emerging as key players in HIV infection. To characterize such RNAs, I will employ an integrated structural biology approach complemented by biochemical and functional assays in vitro and in vivo and I will address two fundamental questions: 1.How does the structure of HIV genomic RNA regulate HIV infectivity?HIV genomic RNA regulates nuclear export, packaging, splicing, and translation of viral proteins. 3D structures are known for short motifs (<200 nt), e.g. TAR and RRE. Such motifs are part of 11 larger domains (>400 nt), whose structures are unknown but conserved across HIV strains suggesting functional importance. We will study domain 2 (450 nt), which encompasses the gag-pol frameshifting motif and is crucial for correct protein synthesis. Our work will offer unprecedented insights into the structural complexity of the genome of an RNA virus.2.How does the structure of human long non-coding RNAs (lncRNAs) affect the host-cell response to HIV infection?HIV infections alter expression of human lncRNAs, e.g. HOTAIR, which regulate Polycomb chromatin remodeling enzymes, e.g. PRC1/PRC2, favoring epigenetic silencing and latency of HIV genes. Interactions between HOTAIR and PRC1/PRC2 are not well characterized at the molecular level. We will study HOTAIR domain 1 (530 nt), which interacts with PRC1/PRC2 and regulates their cellular action. Such work will reveal novel mechanisms of epigenetic gene-silencing that induce HIV latency. By revealing mo