RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The legal and financial condition influencing the diffusion of technological innovations and R+D strategies in Central Europe'.

assistant: **Objectives**

Foreseen ResultsLegal investigation, which will realize by the Patent Offices of the participating countries, will be focused on the Central and East European problems of the intellectual property and the possibilities to solve them.Financial researches carried out with the cooperation of researchers will pay particular attention to the opportunities for the financing of the R + D, especially the diffusion of innovations.Western European investigations might provide ideas about charting ways of modernisation of the economies in the CCE.The proposers concentrate the research on the legal and financial conditions influencing the diffusion of the technological innovations - the topic outlined in section 11.1 of the call for proposals of the COPERNICUS program. They are aimed at collecting information in Central and East European states, concretely in the Czech Republic, Hungary and Romania, as well as in Western Europe, specially in France, Germany and Spain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Active liquid crystal colloids' (ACTOIDS) targeting Seventh Framework.

assistant: **Abstract**

ACTOIDS aim at a vibrant multidisciplinary scientific field of complex soft matter materials, intertwining fundamental questions of activity generated dynamics and technologically attractive self-assembled structuring of colloids in complex fluids. We propose novel materials - active liquid crystal colloids – which possess a unique combination of active, self-propelled, material flow and the discrete ordering of inactive colloidal particles. The subtle coupling of the active flow to the particle dynamics suggests strong potency for interesting material characteristics and applications, such as particle-controllable microfluidic flow-patterns, self-assembly of colloidal structures by material flow, and controllable steering of the flow by external fields. The questions raised range from fundamental and applied material science to transport in living cells. The materials will be approached by continuum mesoscopic modelling based on generalized liquid crystalline dynamics, combined with collaborative experiments. The wide outreach of the proposed research will offer training for the fellow in diversity of skills and competencies building upon his scientific excellence. The fellow will train also on non-scientific issues, including communication and presentation skills, intellectual property rights, ethical issues, language proficiency and cultural awareness. ACTOIDS will be implemented at University of Oxford, an experienced host institution, renown for its ingenuity and highest scientific standards. Mobility of the fellow will create cohesion and institutional connections at bi-lateral and Community level. Strong ties with European and global scientific community, will put the fellow at the cutting edge of the ‘frontier research’ as well as create links to commercialise h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Increasing Social Awarness and ACceptance of biogas and biomethane' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Although Italy has a great potential for biogas production, many non-technical barriers are still present in the current framework. Some of the limiting factors involve public acceptance of the biogas facilities diffusion, as well as lack of a reliable coordination between different stakeholders. Furthermore, normative and legislative inadequacies and deficiencies haven’t facilitated the implementation of these technologies within the national context.The main project objective consists on the construction of a communicative model oriented to spread balanced information, based on environmental and economic benefits, between all the actors potentially involved in biogas/biomethane implementation. At the same time, actions will be focused on reducing the fragmentation between farmers, foresters and other stakeholders in order to reach the minimal facility dimension needed, increased biogas and biomethane penetration and reduce cost management.A participatory process model will be developed as the main project’s approach to reduce social conflict and to include all actors in important common decision making process; starting from the experience, a normative proposal on the participatory process will be recommended.The effectiveness of the proposal will be maximized applying the actions on specific and restricted areas: the study of the energetic unhatched potential deriving from anaerobic digestion of residual biomass or organic waste will constitute the starting point for communication and information campaigns toward the territory and its stakeholders. The attention will be focused on some high energetic potential regions where the diffusion of these technologies struggles to be realized and the effects of project actions on awareness and acceptance will be evaluated.In
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Controlling forelimb actions through basal ganglia to brainstem signaling'.

assistant: **Innovation**

Behavior arises through the combination of movements within distributed circuits. Most work in the past focused on high motor centers and executive circuits in the spinal cord, but how these systems are linked in order to function is poorly understood.The substantia nigra reticulata (SNR), a basal ganglia output, sends projections to the brainstem. Yet how the brainstem processes these inputs to control actions remains unknown. The Arber lab discovered that the parvocellular reticular formation (PCRt) of the mouse brainstem harbors neurons controlling forelimb behaviors including reaching. PCRt neurons receive inhibitory inputs from the SNR. Thus, the SNR-PCRt circuit is an excellent stepping stone for understanding the mechanisms behind self-initiated actions.I propose to investigate the impact of the SNR signaling on the activity of PCRt neurons when a mouse self-initiates forelimb reaching. I will characterize the anatomy and nature of SNR to PCRt connections to understand whether and how this architecture supports forelimb movement. I will combine a behavioral task designed to isolate the neuronal events around the triggering of a self-initiated action with loss- and gain of function perturbations to unravel the building blocks of self-initiated actions. Finally, I will use the task while monitoring the activity of specific SNR and PCRt neurons to understand how the different actors physically implement the operations for self-initiated actions.Together, my experiments will disclose the fine-scale machinery for initiating and controlling an action. This level of understanding is key for designing new therapies to help people impaired in self- initiating actions such in Parkinson’s disease. The fellowship will provide me with the unique opportunity to expand my exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a new process enabling the protection, recycling and reuse of metallic barrels for storage and transportation of goods' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objectives of the intented research project is to create new possibilities in the life-cycle of storage and transportation of specifically toxic or pollutive products (paints, inks...) used in many industrial sites in Europe, by using a new method process and develop the prototype of a specific liner and valves, usable for all type of different metallic barrels throughout Europe and permiting easy re-use of these barrels in good environmental and economical conditions. The aim of the research project is to develop, on the basis of an existing new patent (no 9603466000 of february 13th of 1996 bought by the Prime Proposer), a new type of bonde (or valve plug) and the in-liner process. These SMEs would like to develop industrial applications on the basis of a new patent, firstly on the case of printing industries and then on the development of other activities such as manufacturers of paintings for cars, photographic laboratories, food industries, textile and chemical industries... Considering both economical and technological aspects developing such a prototype with adequate materials and components is too much complicate and risky without the contribution of major RTDs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dynamics of Institutions and Markets in Europe' in the context of a Sixth Framework call.

assistant: **Objectives**

DIME stands for Dynamics of Institution and Markets in Europe", a title meant to strongly emphasise the analysis of the dynamic features of the processes involved in the transition to a knowledge-based economy. One essential goal is to address contemporary challenges facing the European Union, its member states, its regions, its companies and its citizens in managing the transition to a knowledge-based economy and society in the context of its enlargement and of the globalization of the economy. The challenges of co-ordination and organisation involved in generating and exchanging knowledge test the limits of social science understanding and several disciplines have sought to address these issues. The economics of knowledge, the political analysis of multi-level governance, and the social and geographic understanding of proximity, for instance, must be further developed. But many pieces of the puzzle of how to better co-ordinate and organise knowledge generation and exchange remain detached and embedded in different scientific disciplines. The present challenge, and the impetus for the DIME network is the opportunity to develop means of integrating the conceptual, theoretical, and measurement tools employed by different social science communities in order to discover better means of integrating or mobilising existing knowledge as well as generating technological and organisational innovation. Integration among disciplines should favour both intra-disciplinary and cross-disciplinary developments addressing the following scientific challenges:-Knowledge is an Essential and Specific Input in our Economic Systems-The Central Role of Spatiality-Organizational Frames and GovernanceThese scientific advances should help to address policy issues of urgent relevance for the EU:-G
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structure of a Human GABA(A) Receptor Complex' to be submitted under Horizon 2020.

assistant: **Abstract**

GABA(A)Rs are the principal neurotransmitter receptors at the inhibitory synapses. The majority of these receptors are anchored at the inhibitory postsynaptic compartment by the central scaffolding function of gephyrin. A dysfunctional receptor clustering by gephyrin leads to abnormal neurotransmission and neurodevelopmental disorders, including anxiety disorders and epilepsy. Recent advances in the structural studies, most recently by cryo-electron microscopy (cryo-EM), have elucidated several heteropentameric GABA(A)R structures. All of these illustrate receptors in isolation. However, in a physiological synaptic context, GABAARs exist and function in close association the auxiliary protein LFPLH4 as well as with anchoring proteins including gephyrin, collybistin (CB) and the adhesion molecule neuroligin 2 (NL2).  To understand the architecture and function of this fundamental complex, I will work on the structural elucidation of the human GABA(A)R-gephyrin-CB-NL2 supramolecular complex by single-particle cryo-EM. Structural studies will be followed by validation using additional biochemical, biophysical and electrophysiological analysis of mutant constructs. These data will not only provide the first insights into the supra-molecular organization of a major human neurotransmitter receptor. As the dysfunctional GABAergic neurotransmission manifest itself in lethal neurodevelopmental disorders such as Alzheimer’s and also epilepsy, structural insight into the central complex will also help to understand the molecular basis of these disorders.


**Keywords:** GABA(A) Receptor, Gephyrin, Cryo-EM, Collybistin, Neuroligin, Inhibitory postsynapses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'VHIO International postDoctoral programme for translAtional research' under Horizon Europe.

assistant: **Concept**

The proposed “VHIO International postDoctoral programme for translAtional research” (VIDA) aims at enabling outstanding junior scientists of all nationalities to develop a competitive research project at VHIO, an international reference center for personalized medicine in oncology that thanks to its pioneering model of multidisciplinary and translational research is among the leading comprehensive cancer centers in Europe.VIDA aims to nurture excellent postdoctoral fellows to advance research, personalised medicine in oncology and patient health care in Europe. Following a fair, merit-based and inclusive recruitment process, the programme will hire 12 postdoctoral researchers to carry out a research project that will benefit from a stimulating and creative environment, career development and mentoring schemes, and access to high-end technologies and facilities. Importantly, they will benefit from a tailored advanced training programme on the latest technologies, open science, gender and innovation, and from a specific mentoring scheme, with the opportunity to build valuable national and international networks with different actors in academia, hospitals, industry, editors and universities.  VIDA counts on the support and collaboration of 15 associated partner organisations. The trained fellows will be equipped with skills and knowledge to tackle relevant clinical and research questions, and ultimately pursue new approaches to diagnose and treat oncology diseases.  Overall, the VIDA Programme will provide fellows skills and competences for developing a successful career in both the academic and non-academic sector and VHIO is a unique institute to bring them the possibility of contributing to improve prevention, early diagnosis, monitoring and treatment of cancer patient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gibberellins in tomato ovule development', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Bioactive gibberellins (GAs) are plant hormones that regulate important processes in the life cycle of higher plants. GA deficiency leads to male sterility as a result of abnormal anther development. GAs produced in the embryo and/or endosperm are required for normal seed growth and survival. In tomato (Solarium Lycopersicon L.), synthesis of bioactive GAs takes place in the ovary until it develops completely, and it is induced again as a consequence of pollination. Treatment of wild type tomato flowers w ith gibberellic acid can induce parthenocarpic fruit growth and inhibition of GA biosynthesis prevents fruit growth. Although GAs are indispensable in ovule and fruit development, it is not known which processes are directly regulated by GA. In addition, several other phytohormones are known to be involved in ovule development but it is not clear whether these act together with gibberellins or act independently. Fertility, seed set and fruit development are important traits for crops. We want to understand better the role of GAs, their way of action, and interaction with other hormones in tomato ovule/seed and fruit development. Tomato is an important crop widely used in plant science that can be used as a model for other members of the Solanaceae family, s uch as aubergine and sweet pepper. We want to approach the project objectives with cDNA AFLP to display GA responsive gene activity during ovule development and early fruit growth. In addition, from this genome wide transcript profile also an inventory can be made of developmentally regulated genes in the ovule. The function of most interesting genes will be analyzed in mutant tomato plants or in mutants from other species. The Marie Curie Return and Reintergration Grant can make possible the establishment of a thor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Novel Mechanisms of Airway Inflammation'.

assistant: **Concept**

This is a proposal to define a fundamentally new and potentially dominant pathway of airway inflammation involving the p53 homolog p73 acting through regulators of cytokine mRNA stability. We anticipate that the studies described herein will contribute to our understanding of acute and chronic airway diseases and the development of novel therapies to combat them. The proposal is divided into four parts:  1. Establish a Role for p73 in the Innate Immune Response in the Upper Airways Our genetic models for loss of p73 function reveal the unexpected finding that ciliated airway epithelia play a major and perhaps dominant role in airway inflammation. We will exploit genetic and cellular models to establish the broader significance of these cells and of p73 in regulating the innate immune response and how they contribute to human disease. 2. Define the Signaling Pathways of the Innate Immune Response in Airway Epithelia We will use mass spectrometry, shRNA technology, and small molecule inhibitors to dissect these pathways linking p73 to airway inflammation and develop chemical screens as a basis of therapeutic intervention. 3. Determine the Genetic Targets of p73 that Control Airway Inflammation Our preliminary work has identified key regulators of mRNA stability downstream of p73, and has implicated them in the destabilization of inflammatory ytokine mRNAs. These observations suggest a novel mechanism for the control of airway inflammation involving mRNA stability. 4. Mouse Models for Dcp1² Loss-of-Function The identification of Dcp1² as the strongest target of p73 offers a new and fundamental approach to the control of airway inflammation. Genetic models in mice will provide new insights into the role of mRNA stability for airway inflammation and novel models of human air
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Deciphering collagen mineralization process by dynamic imaging in liquid' (DYNAMIN), addressing dissemination and exploitation.

assistant: **Impact**

Bone is a complex nanocomposite with outstanding mechanical properties arising from the nanoscale interaction between its two main building blocks: type I collagen fibrils and hydroxyapatite crystals. Despite its clinical relevance, the mechanisms governing bone formation are still poorly understood, mainly due to the complexity of the processes. During bone formation and remodeling, non-collagenous proteins and proteoglycans act synergistically to regulate the mineral deposition process, participating in multiple signaling pathways involving regulatory molecules, osteoblasts and osteoclasts.Many of the studies performed until now relayed into simplified in vitro models that hardly represent this complexity. Furthermore, methods traditionally applied only provide snapshots of this process, unable to extract dynamic information. To really understand the mechanisms regulating bone mineralization, we need to simultaneously visualize its different components in its context, to be able to monitor their interactions. In this project, I propose to combining liquid-phase electron microscopy and immunolabelling, with which I aim to bring together dynamic imaging of a complex biochemical process and the identification of the biomacromolecules involved. By recreating the mineralization conditions inside the liquid cell, I aim to obtain real time data on nucleation sites, crystal growth and mineralization dynamics. The combination of dynamic imaging with immunogold will allow me to monitor the direct interaction of these regulatory molecules with the mineral particles at nanoscale resolution. By means of this new exciting approach I expect to provide unprecedented data on the processes of bone formation and take a step forward in the application of LPEM in biological materials.


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