RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Understanding immune evasion by malaria parasites'.

assistant: **Objectives**

The deadliest form of human malaria is caused by the protozoan parasite, Plasmodium falciparum, which annually infects millions worldwide. Its virulence is attributed to its ability to evade the human immune system, by modifying the host red blood cell surface to adhere to the vascular endothelium and to undergo antigenic variation. Antigenic variation is achieved through switches in expression of hypervariable surface ligands named PfEMP1. These proteins are encoded by a multi-copy gene family called var. Each individual parasite expresses a single var gene at a time, whereas the remaining ~60 var genes found in its genome are maintained in a transcriptionally silent state, a phenomenon known as ""allelic exclusion"". These antigenic switches allow the parasite to avoid the human immune response and maintain a long-term infection. How mutually exclusive expression is regulated is still elusive.The rationale of the proposed study is that understanding the molecular mechanisms by which the parasite evade human immune attack would lead to the development of therapeutic approaches that disrupt this ability and would give the human immune system an opportunity to clear the infection and overcome the disease.I will focus this research project on understanding one of the unsolved mysteries in gene expression which is responsible for regulating antigenic variation in P. falciparum: the nature of ""communication"" between genes that allows expression of only a single gene at a time and the selection of the ""chosen one"" for activation while the rest of the gene family remains silent.The expected outcome of this knowledge is new concepts for disrupting the parasite’s ability to evade immune attack which will be exploited for the discovery of novel targets for drug and vaccine d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Self-contracting vascular networks: From fluid transport to autonomous locomotion of soft materials' to be submitted under Horizon Europe.

assistant: **Abstract**

Liquid flows in vascular networks are among the most effective ways to transport matter and information for life. Artificial vascular networks have mimicked this strategy without reproducing the same level of autonomy and adaptability. From animals to fungi, the most adaptable organisms control fluid transport with vessels that actively contract upon local sensing of stimuli. This adaptative fluid transport enables functionalities in organisms such as autonomous locomotion toward objectives. How are the orientation and rate of fluid flows controlled by self-contractions? How do these self-contracting networks tailor autonomous functionalities? So far, we do not know.  Studies on organisms are limited to observations and lack the systematical characterizations required to apply these observations to artificial materials. Self-Flow hypothesizes that artificial vascular networks containing distributed sensors and actuators can decipher how self-contractions enable adaptable fluid transport. From there, materials containing self-contracting artificial vascular networks will enable systematical studies on the emergence of autonomous functionalities. With this experimental asset reinforced by theoretical and numerical models, my group and I will address the following questions: •Q1 DELIVER:  How do self-contractions transport fluids across networks?•Q2 ADAPT:  How do self-contractions autonomously adapt to the need of the network? •Q3 BEHAVE: How do self-contractions enable living matter functionalities?Self-Flow will combine active matter and mechanistic approaches to model fluid transport in self-contracting vascular networks. I will use these results to design active vascularized materials that use fluid transfer to autonomously locomote towards objectives and exchange inf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Illuminating the Dark MicroProteome in Innate Immunity' (MicroIMMUNE), addressing dissemination and exploitation.

assistant: **Impact**

Genome annotation, transcriptomic and proteomic pipelines have traditionally dismissed proteins encoded by short open reading frames (sORF) known as microproteins. This provides a pool of unexplored functional genes. Despite the increasing body of work in identifying the microproteome in different model organisms and cell lines, only a few have been functionally studied showing diverse regulatory roles in multiple cellular pathways.In MicroIMMUNE, I present a 3-aim workflow combining computational and synthetic biology, protein and genetic engineering approaches designed to systematically uncover the microproteome atlas and investigate its interactome and functional role in innate immune cells.We aim to:1) Identify microproteins expressed in innate immune cells under resting and stimulating conditions, using state-of-the-art computational and experimental approaches to study the microproteome. 2) Develop genetic code expansion technologies in innate immune cells to incorporate non-canonical amino acids to study the localization and binding partners of microproteins. 3) Elucidate the function of microproteins in innate immune cells by combining genetic engineering with an array of high-throughput functional assays and automated analysis pipelines. Our research output will address key questions such as: What is the microproteome atlas in innate immune cells and how does it vary upon activation? Where are the microproteins localised and in which protein-protein interactions are they involved? What functions do different microproteins play in innate immune cells? Understanding the role of microproteins in innate immune cells can revolutionise our understanding of the immune response at a fundamental level and open new avenues for therapeutic interventions in which new antim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Researchers’ Night in Sweden: ForskarFredag' in the context of a Seventh Framework call.

assistant: **Objectives**

Researchers’ Night in Sweden, ForskarFredag, FF (Research Friday) will consist of events taking place in nine towns and cities throughout Sweden on 28th September 2007. FF will be coordinated by Vetenskap & Allmänhet, VA. Participants include universities, science discovery centres, a regional council, a competence development agency and the Swedish Research Council. The project is facilitated by the participants’ extensive links with industry and academia.  The primary objective of FF is to provide a forum for the public and researchers to meet and communicate face-to-face. Innovative and original hands-on activities in informal and festive environments will be arranged at each FF event. The aim is for fun, relaxed actions and engaging dialogues that will attract the broad public, especially those not specifically interested in research. The importance of international cooperation  will be emphasised, thus giving a sense of Sweden as part of the European scientific community, and explaining how this benefits us all.  The impact on the public at large will be significant since the number of visitors is estimated to be at least 8 900. Those unable to attend the venues will be able to follow some of the activities through a web cast. Live media reports and news items are also expected to cover the day’s events. Furthermore, children aged 6-18 will be invited to take part in a national drawing competition.   Local event schemes will vary, but all will have a common message: research is fun and exciting and influences everyone’s day-to-day life. To ensure maximum visibility, an awareness strategy will be implemented. Unanimous objectives, similarity of contents as well as a website providing all the necessary information will be common denominators of FF. In short, FF will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Capacities for More Effective Long-Term  Climate Change Governance' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The mismatch between the timescales of climate change and the action frameworks of public institutions undermines global governance with profound implications for the prospects for human prosperity on a changing Earth. Effective and responsible governance requires identifying and cultivating a set of capacities, tools, and institutions that better align decision-making and action time horizons with those of the Earth system. CAMELOT addresses this gap by introducing a groundbreaking theory of long-term governance capacities, centered on imagination as the core enabler of long-term learning, risk assessment, and inter-temporal agency. By integrating insights from Earth system science and governance, futures studies, and cognitive science, CAMELOT studies which methods at the science-policy-society interface can cultivate these capacities most effectively across diverse governance scales and contexts.The project employs two innovative empirical approaches. First, it systematically evaluates six methods of science-policy-society engagement, such as scenario development and assessment reports, to determine their effectiveness in enhancing long-term governance capacities. Second, it pioneers a cutting-edge science-policy engagement exercise, testing its impacts on long-term governance capacities among climate policymakers across scales (multilateral, national, local). Seizing the opportunity of an opening policy window, all empirical work will focus on the issue of climate tipping points.The project advances theoretical debates on effective governance, intertemporal agency, and science-policy-society relations in an era of long-term environmental and socio-political risks. These insights have broad applicability in domains such as biodiversity conservation, genetic modificat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nano-Hybrid Graphene-Based Ink for Printable Flexible Transparent Applications' (NanoGraphInk) targeting Horizon 2020.

assistant: **Abstract**

Aim: Development of conductive graphene ink for printed flexible transparent applications.State-of-the-art: Advancing of printed electronics via high quality graphene inks for highly flexible displays of higher energy class and better visibility, and next generation products as wearables and transparent displays.Innovation: First graphene/carbon quantum dots (CQDs) and graphene nanobuds conductive inks. Essential study to warrant that final printed circuits demonstrate zero nanoparticles emissions.Excellence: Exploitation of graphene’s unique properties. High interdisciplinary nature linking also directly research with industry.Capacities: I have multidisciplinary background, advanced skills and extensive experience in synthesis and characterization of nanomaterials, excellent track record. Prof. Ferrari’s expertise ensures proper supervision. Cambridge possesses essential instrumentation and is excellent host institution. ""TheGrapheneBox"" secures commercialization of inks.Impact: Gain skills for advanced characterization techniques as TEM, recognized as an expert in graphene inks, raise my profile by joining Cambridge, expand my network. Dealing with the hot market of printed electronics, commercialized products will find a direct industrial use.Use of foreground: Proper dissemination/exploitation of results in form of conference participations, patents, commercialized products, and publications at high impact factor journals warranted by project’s excellence. Respect to intellectual property. Follow Horizon 2020 priority for open science. Rapid communication of the outcomes by a set of measures.Implementation: Solid work plan. Use of CQDs and functionalized fullerenes for graphene’s dispersion in water. Modifiers tuning ink’s features to acquire proper rheological p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Higher Dimensional Aspects of First-Order Logic' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

First-order logic is the foundational formal language used to express almost all of modern mathematics, and improved understanding of this logic is linked to many recent advances in mathematics.  Consequently, there is a well-developed framework to study first-order logic within the mathematical discipline of 1-dimensional category theory.  However, there are still many important and yet unexplored aspects of first-order logic that only emerge in 2-dimensional category theory.  My research has uncovered new descriptions of the syntax and semantics of first-order logic as algebraic structures for a pseudo-monad, a mathematical gadget found in 2-dimensional category theory.Supported by the Marie Skłodowska-Curie Actions programme, the HiDimAFOL project will establish new results concerning the higher dimensional aspects of first-order logic by investigating the pseudo-monads related to the syntax and semantics of first-order logic.  The project will deepen our understanding of first-order logic and lead to new mathematical applications on the interface of algebraic logic, categorical logic and model theory.  By highlighting the applications of higher dimensional category theory to mathematical logic, we will promote unity among the various logical traditions that exist in mathematics.


**Keywords:** 2-dimensional category theory, categorical logic, pseudo-monad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Rapid therapy development through Open nCoronavirus Vaccine Platform', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The OPENCORONA consortia will test a therapy that protects against 2019-nCoV infection and/or disease in a phase I clinical trial in 24 months. The spread of the 2019-nCoV (or SARS-CoV-2) between the Jan 21 and Feb 11 has expanded alarmingly. There are >43000 confirmed cases of which >1000 has died. Around 7000 have a severe disease. The infection still mainly affect mainland China, although an increasing number of cases are seen outside China. The major question is what will happen when China halts its massive isolation campaign. No approved human coronavirus immunotherapy or vaccine exists. Thus, speed in therapy and vaccine development is critical. Genetic analysis shows that the 2019-nCoV envelope and receptor binding domain only has a 75% homology with other human coronaviruses. Thus, existing immunotherapies and vaccine candidates against other coronaviruses, such as SARS, will not be useful against 2019-nCoV. We will use the DNA vaccine platform as this is currently the most rapid and robust vaccine platform today. We will generate chimeric 2019-nCoV genes (Figure 1) and select the most potent DNA vaccine/immunotherapy candidate delivered by in vivo electroporation that protects against 2019-nCoV infection and/or disease in animal models and take this to phase I clinical testing. The partners in the consortium have done this before and all know-how for reliable development is present. KI and FoHM will develop vaccine candidates and infectious models, JLU will test candidates for over-activation of innate immunity, IGEA will provide a CE marked device for in vivo electroporation in humans. Cobra will produce plasmid according to GMP, Adlego will perform toxicological testing according to GLP, and Karolinska will write the  (Investigator’s brochure) and IMPD (Inves
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Signalling of Minor Pocket Agonists at CXCR4' (SMiPAX4) targeting Horizon Europe.

assistant: **Abstract**

The following project, SMiPAX4, conducted in the academic group of Jean-Philippe Herbeuval (Univeristy of Paris, France), is at the cross section of immunology and pharmacology. Moreover, due to its direct application potential and the subsequent industrial placement to deepen the acquired knowledge at Sanofi it is also cross sectional between academia and industry. The main objective of the project is to understand the mode of action of small molecules, functionally causing a reduction of immune response, binding into the minor binding pocket of the G protein coupled receptor CXCR4. The signalling cascade as well as the implication of different expression levels of the target CXCR4 will be explored through different biochemical techniques. Protein-protein interactions will be identified using Bioluminescence energy transfer (BRET) techniques, increase or decrease of second messenger molecules will be identified using biosensors, and phosphorylation states, up- or downregulation of (signalling) proteins will be measured using flow cytometry or western blotting. Inflammation of cells when controlling the impact of silencing certain signalling molecules will be controlled by measuring the levels of inflammation markers. Due to the projects implication in (auto)immune and other inflammation diseases it is relevant for cluster 1, Health, of the Horizon Europe programme. The project shows great potential in the area of impact due to its unique target potentially helping people that do not respond well to already approved medication. Both, the dissemination of results producing multiple publications in peer reviewed journals, talks and posters at scientific meetings as well as the potential of creating market within the EU are very probable with completion of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Technology transfer between modern algorithmic paradigms' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The two most recognized algorithmic paradigms of dealing with NP-hard problems in theoretical computer science nowadays are approximation algorithms and fixed parameter tractability (FPT). Despite the fact that both fields are by now developed, they have grown mostly on their own. In our opinion the two fields have critical mass allowing for synergy effects to appear when using techniques from one area to obtain results in the other, which is the main theme of the project.Furthermore, practical effectiveness of randomized local search heuristics is a not yet understood phenomenon. We believe that substantial increase of our understanding of superpolynomial running times in recent years should allow for rigorous proofs of parameterized and approximation results obtained by those methods.Based on our experience with parameterized complexity and approximation algorithms we propose three research directions with potential of solving major long-standing open problems in both areas with the following objectives.(a) Transfer from Approximation to FPT: use the PCP theorem to prove lower bounds for exact parameterized algorithms under the Exponential Time Hypothesis and take advantage of extended formulations in FPT branching algorithms.(b) Transfer from FPT to Approximation: utilize parameterized algorithms tools in local-search-based approximation algorithms and explore the potential of proving new inapproximability results based on the Exponential Time Hypothesis.(c) Rigorous Analysis of Practical Heuristics: unravel the practical effectiveness of randomized local search heuristics by proving their parameterized and approximation properties, when given subexponential or even moderately exponential running time.Our objectives lie in the frontier of fixed parameter tractability