RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Contour dynamics and singularities in incompressible flows'.

assistant: **Concept**

The search of singularities in incompressible flows has become a major challenge in the area of non-linear partial differential equations and is relevant in applied mathematics, physics and engineering. The existence of such singularities would have important consequences for the understanding of turbulence. One way to make progress in this direction, is to study plausible scenarios for the singularities supported by experiments or numerical analysis. With the more sophisticated numerical tools now available, the subject has recently gained considerable momentum. The main goal of this project is to study analytically several incompressible fluid models. In particular solutions that involve the possible formation of singularities or quasi-singular structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genetic programming of human cell factories for the specific treatment of cancer and viral infection.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The natural immune response to cancer and HIV is ineffective. To overcome problems of immune recognition we developed the chimerical receptor (CR) approach in which lymphocytes are redirected to efficiently eliminate desired targets. Our major objective is to optimise the CR approach towards the realisation of its clinical potential. We aim at splicing antibody and TCR-based recognition elements specific to tumours and HIV to variety of cell-activation chains and select the CR configurations yielding the most potent cells. Towards clinical application, efficient and safe retroviral and lentivirus based vectors will be developed, transduced into patient lymphocytes and tested for their ability to induce tumour regression in SCID mice. We aim to deliver vectors, protocols and optimised bioprocess to engineer a safe and efficient cell factory. Building upon our expertise and patents will allow us to launch the CR approach into clinical trials and eventually, to effective immuno-gene therapy. Description of the work Our groups have pioneered the CR approach for the immunotherapy of neoplastic and viral diseases. In the clinical application, patient-derived lymphocytes will be transduced with a vector harbouring CR genes composed of a target recognition moiety fused to a cell activation molecule. These genetically programmed cells upon reinfusion into the patient, are expected to home to, and lyse diseased cells. In this project, we plan to share our expertise in different disciplines and integrate it to improve and optimise the CR approach through a preclinical phase of testing in mouse models. First, we will construct a panel of CR genes using different recognition moieties enlarging the prototypic 'T body' to include variable regions of TcR, ligands for receptors overexpr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Computational models of Computer Narrative' in the context of a Sixth Framework call.

assistant: **Objectives**

This project aims to bring together two existing efforts in modelling the automated generation of stories, that used in ProtoPropp, developed in Madrid using AI techniques, and that used in MEXICA, developed in Mexico based on the Engagement-Reflection cycle, a psychological theory of how humans compose stories. The integration of the two different approaches should lead to a richer computational model of story generation. A fellowship is requested for Dr. Rafael Pérez y Pérez, developer of MEXICA, to come to Universidad Complutense de Madrid, where ProtoPropp is currently under development by a team of researchers. The research group at UCM has ongoing collaborations with related research efforts in Europe: on interactive narrative (University of Teeside, U K), conceptual blending (U. of Coimbra, Portugal), and narratology (U. of Hamburg). There is an ongoing bilateral integrated action with U. of Coimbra, and several of those sites have participated in a proposal for a coordination action on related topics under the FET program of FP6.The proposed project intends to construct a generic computational model for the generation of narrative integrating all these different techniques. The integration and cooperation between these techniques would be structured around a formalised representation of the relevant knowledge in terms of an ontology, constructed as an extension to the ProppONTO and KIDSOnto ontologies developed using the OWL standard by the Madrid team, and it should be progressively extended to account for the concepts involved in the new techniques over the duration of the project.This ontology, as a reusable resource in a standard format, would be a valuable result of this project. The researcher benefiting from the fellowship is a pioneer in the field of com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Monitoring the Corrosion State of Glass Objects by Optimized Micro-Computerized X-Ray-Tomography' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Background During their lifetime glass objects may have experienced different environmental conditions (in soil, water, polluted or humid air etc.). The corrosion process changes the surface structure of sensitive glasses. Based on leaching processes a water-rich gel layer with microcracks, covered by a crust of corrosion products and dirt is built up. The actual preservation state of a particular glass object reflects all its history and influences its future behaviour. Any effective conservation concept for glass objects has to be based on the knowledge about its actual corrosion state. Recognized methods for the analysis of corroded glass, like SEM-EDX or XPS are destructive, as they require embedding in a polymer to prepare cross-sections or sputtering to obtain depth-profiles. Operating in vacuum alters the water-containing gel-layer which is to be examined. Computerized X-ray Tomography (CT) is an imaging technique first developed for medical radiology. The only application of CT in the cultural heritage domain dealt with stone deterioration. Detecting the corrosion state of glass objects is feasible, in principle, by visualizing the porous structure and the water-content of the corroded layer. However, the existing equipment has to be improved and adapted for this purpose.  Objectives The aim of this project is to introduce micro- computerized X-ray Tomography (mCT) as a new non- destructive tool for glass conservation. As a result, the main objectives are: - to adapt/improve mCT equipment to analyse glass objects; - to use model glasses to calibrate mCT analysis; - to detect the state of corrosion of glass objects by mCT; - to demonstrate the potential of mCT for the improvement of restoration/conservation techniques for sensitive glasses.  Work programme In ord
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cerebellar networks alterations in prion diseases' (1994-1998).

assistant: **Concept**

Transmissible Spongiform Encephalopathies, or Prion diseases, are a group of slow and deadly degenerative pathologies of the Central Nervous System affecting not only animals but also humans. They encompass mainly Creutzfeldt-Jakob disease in man, scrapie in sheep and goat and bovine spongiform encephalopathy. One of the least known aspects of these rare pathologies is the sequence of events triggered by the conformational change of PrPc into PrPsc, and leading to neuropathological degeneration. The present proposal is specifically designed to address this central problem, by a collaborative approach between four European laboratories with strong expertise in molecular biological, morphological and electrophysiological techniques. We feel that a global approach, integrating the specific data obtained by each of these techniques in a unified view, is the only way to get an efficient cross-talk and a rapid progress in the understanding of these puzzling pathologies. We have chosen to concentrate on the study of two specific and related problems: 1 - what is the role of PrPc in normal neurons, glia and neural circuits? and 2 - what are the structural changes leading to the morpho-functional alterations of prion-infected CNS structures? The cerebellum was taken as a model structure to study the normal and pathological aspects of PrP because it is one of the best known brain parts, which insures a rapid and precise integration of new data in a coherent body of biological relationships and because there is a significant cerebellar tropism of PrP physiopathology. Single cell RT-PCR, Golgi impregnation and immunohistochemical labelling, photon and electron-microscopical analysis and electrophysiological recordings in normal, in PrP0/0 and in scrapie-infected murine strains will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Determining the drivers and importance of scavenging behaviors in a changing world using agent based modeling approaches.' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the face of global change and a rapidly changing world ecologists must understand the fundamental components of ecological systems. Unsurprisingly, much research has focused on the trophic links of which ecosystems are constructed. However, despite this attention one particular type of trophic link, scavenging, has been relatively ignored. This is despite estimates showing that scavenging accounts for more energy transfer in comparison to predation, clearly demonstrating its crucial role in determining ecosystem dynamics. Yet scavenging is a still a poorly understood behavior as despite its prevalence across predators, little explanation is available for the enormous level of variation in the level of scavenging both across species and with them. SCAVENGER proposes to address this imbalance using a state of the art simulation approach recently developed by the fellow to test the ecological and physiological drivers of scavenging behaviors and explore the importance of this behavior in extinct, extant and potential future ecosystems. By using a combination of biomechanics, energetics and macroecology in an agent based modeling framework I will test the drivers of scavenging efficiency focusing on the roles of body size, locomotion, biomechanics, population dynamics and environmental factors such as temperature. After mapping out the drivers of scavenging this approach will be applied to both understanding the  role of scavenging in an extinct system, were the role of scavenging in early Hominds will be explored, and in future scenarios, were systems of conservation and management importance will be identifies as part of a secondment at the Zoological Society of London. The SCAVENGER proposal will allow me to address a substantial gap in the understanding of an importa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The European Industry - Academia Network for RevIsing and Advancing the Assessment of the Soil Microbial TOxicity of Pesticides'.

assistant: **Innovation**

In ARISTO (the European Industry - Academia Network for RevIsing and Advancing the Assessment of the Soil Microbial TOxicity of Pesticides), leading universities and industrial partners join forces to perform a cutting edge research and doctorate training programme tackling the global challenge of minimising the environmental off-target effects of pesticides.The multi-sectoral approach of ARISTO, interlinking disciplines from soil microbiology, microbial ecology, environmental chemistry and risk assessment, will generate the new generation of Microbial Ecotoxicologists specialized in pesticides-soil microbes interactions. The research challenge of ARISTO is to produce benchmarking knowledge supporting the development of advanced tools and procedures, based on the response of key microbial indicator groups like ammonia-oxidizing microorganisms (AOM) and arbuscular mycorrhizal fungi (AMF), for the comprehensive assessment of the toxicity of pesticides on soil microorganisms. ARISTO offers doctorate fellows a challenging training programme build along 5 research objectives:(1) to develop pioneering in vitro tests, as a first conservative step, to assess the toxicity of pesticides on distinct AOM (ESR1) and AMF (ESR2) strains(2) to develop advanced experimental lab and field tests to assess the toxicity of pesticides on natural soil assemblages of AOM (ESR3) and AMF (ESR4), as a more realistic toxicity assessment step(3) to develop an ecosystem-level toxicity assessment: identify the response of soil microbial networks to pesticides (ESR5) and explore the impact of pesticides on microorganisms from different trophic-levels within the soil food-web (predator - prey) (ESR6)(4) to develop novel tools and procedures to determine the soil microbial toxicity of pesticide mixtures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hybrid Coordination Aggregates (MOFs) For Carbon Dioxide Adsorption', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Existing CO2 capture technologies, such as amine-based absorption and cryogenic distillation, face challenges and problems including high energy requirements, large infrastructure needs, and high costs. These technologies often require significant retrofitting or integration into existing industrial processes, limiting their scalability and commercial viability.  In contrast, the utilization of MOFs (Metal-Organic Frameworks) for CO2 capture has garnered significant interest due to the numerous advantages they offer compared to other materials such as high adsorption capacity, selectivity, tunability, regenerability, and potential for direct utilization, making MOFs a promising solution for efficient and effective CO2 capture. However, it is challenging to design MOF materials with extremely high CO2 capture capacity, gas selectivity, and water stability along with moderate regeneration energy as water dissociation causes hydroxyl-poisoning that impairs CO2 sorption by both high temperature and moisture exposure. Additionally, the high energy consumption during blowdown and evacuation steps for the process cycle of MOFs need to be improved to ensure long-term performance. The novelty of this work lies in its ability to strengthen the interaction between CO2 molecules and the MOF structure through an innovative dual activation method, utilizing both N and S atoms. This approach surpasses conventional single-atom activation in MOFs, resulting in enhanced binding. Furthermore, the incorporation of Lewis Base Sites (LBSs) has become increasingly popular for reducing the energy needed for MOF regeneration, consequently improving CO2 binding affinity, selectivity, and reversibility. Advanced thermal modeling will be employed to analyze the dynamic processes of CO2 adsorption/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Specific facilities for grouping together and treating waste materiald from construction sites for optimum recycling' (1994-1998).

assistant: **Innovation**

The building and civil engineering works sector produces a considerable volume of scrap and waste materials from its sites, greater than that of household demonstration centres with dissemination of best practices. this waste could be put to profitable use. An evolution in the practises of the small and medium-sized industry sector is necessary, in order to minimise the cost of waste disposal and to conform to the new national and european regulations for the protection of the environment. However, the inappropriateness of the present means or those under study, for the elimination of waste issuing mainly from households and from the manufacturing industry does not permit a concrete and economically acceptable solution for the optimal recycling of waste from building and construction sites. The aim of the project is to draft codes of good practice and to develop a skid concept for the grouping together or the specific treatment of waste from the building and civil engineering works sector, which will lead to the setting up of pilot demonstration centres with dissemination of best practices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Public Marketplace Platform for Digital Marketing applied for driving in-store Sales.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Performance marketing generates 20% e-commerce sales, but only 1% brick & mortar retailer sales. 90% total purchases are still made in-store and 60% in-store purchases are prepared online (webrooming). There is a need for performance-based marketing and programmatic advertising solutions that can leverage the advantage of online trends and digital ad spaces to increase sales. Nowadays, there is difficulty for tracking marketing actions to measure sales at article level. No public marketplace to structure business relationships and heterogeneous, declarative and high-friction customer experiences provide limited diffusion, lack of measure of ROI on advertising and many digital advertising spaces that are difficult to exploit. Publishers’ proprietary platforms imply advertisers need extra resources to interact with each one. AD-TO-STORE is the first ad-to-store affiliate network, able to track in-store purchases generated by advertising at article level, in a scalable cloud environment: one-stop public marketplace; third-party sales tracking system at article level; real-time and item-based promotions; and omnichannel identification means. Advertisers will have campaigns based on advanced parameters and events. Agencies will have full ad space management. Publishers will be able to format campaigns and set the audience, and consumers can earn and redeem rewards. To end-users, AD-TO-STORE will be a single marketplace (concentration of ad space), enabling access to programmatic display, pay-per-sale and search retargeting throughout a reduced management fee. It will help in measuring ROI at article level and per store or area and have better consumer knowledge, which will lead to a higher conversion rate. For Browse & Go, it will be the central product for pivoting to futur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The GEne Therapy INnovation Training Network' (GET-IN).

assistant: **Innovation**

Gene therapy has transitioned from a distant hope to reality. To date 3 rAAV gene therapies are approved in the EU, >30 phase III clinical trials ongoing, and exciting developments in therapeutic gene editing in the pipeline. However, fundamental limitations in the bioprocessing of gene therapy vectors limit broader application. Manufacturing is not automated, with an open process environment, limited scalability and robustness, and inefficient downstream processing, resulting in huge footprint and exceedingly high cost of goods. The field requires scalable manufacturing technology with modular design to produce high doses for large patient groups at a fraction of cost. Improved delivery approaches with increased specificity and efficacy at lower doses are needed to overcome emerging safety concerns observed in clinical trials. Prediction of therapeutic efficacy in man is challenging due to a species barrier, underlining the need for humanized models to reduce attrition rates in the development pipeline.To overcome these challenges, innovation driven by multidisciplinary approaches is direly needed. GET-IN is a doctoral network of 7 academic and 8 non-academic partners, with expertise in vectorology, genome editing, process engineering, biomanufacturing and innovative humanized models. Together, they provide an excellent training framework for 10 Doctoral Candidates (DCs) who will be the future innovators in the gene therapy field. Research in GET-IN will investigate disruptive innovations including optimised bioprocessing, digital simulation, novel and improved vectors and genome editors, targeted delivery systems, and human organ-on-chip models for more relevant safety and efficacy evaluation. The joint training programme will emphasise responsible, cooperative resear