RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intelligent observation and execution of Actions and manipulations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

IntellAct addresses the problem of understanding and exploiting the meaning (semantics) of manipulations in terms of objects, actions and their consequences for reproducing human actions with machines. This is in particular required for the interaction between humans and robots in which the robot has to understand the human action and then to transfer it to its own embodiment. IntellAct will provide means to allow for this transfer not by copying movements of the human but by transferring the human action on a semantic level. IntellAct will demonstrate the ability to understand scene and action semantics and to execute actions with a robot in two domains. First, in a laboratory environment (exemplified by a lab in the International Space Station (ISS)) and second, in an assembly process in an industrial context.IntellAct consists of three building blocks: (1) Learning: Abstract, semantic descriptions of manipulations are extracted from video sequences showing a human demonstrating the manipulations; (2) Monitoring: In the second step, observed manipulations are evaluated against the learned, semantic models; (3) Execution: Based on learned, semantic models, equivalent manipulations are executed by a robot.<br/>The analysis of low-level observation data for semantic content (Learning) and the synthesis of concrete behaviour (Execution) constitute the major scientific challenge of IntellAct.Based on the semantic interpretation and description and enhanced with low-level trajectory data for grounding, two major application areas are addressed by IntellAct: First, the monitoring of human manipulations for correctness (e.g., for training or in high-risk scenarios) and second, the efficient teaching of cognitive robots to perform manipulations in a wide variety of application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Engineering a scaffold based therapy for corneal regeneration' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Corneal blindness resulting from disease, physical injury or chemical burns affects millions worldwide and has a considerable economic and social impact on the lives of people across Europe. In many cases corneal transplants can restore vision however the shortage of donor corneas suitable for transplantation has necessitated the development of alternative treatments. The aim of this project is to develop a new approach to corneal tissue regeneration. Previous approaches at engineering corneal tissue have required access to donor cells and lengthy culture periods in an attempt to grow tissue in vitro prior to implantation with only limited success and at great expense. Our approach will differ fundamentally from these in that we will design artificial corneal scaffolds that do not require donated cells or in vitro culture but instead will recruit the patient’s own cells to regenerate the cornea post-implantation. These biomaterial scaffolds will incorporate specific chemical and physical cues with the deliberate aim of attracting cells and inducing tissue formation. Studies will be undertaken to examine how different chemical, biochemical, physical and mechanical cues can be used to control the behaviour of corneal epithelial, stromal and endothelial cells. Once the optimal combination of these cues has been determined, this information will be incorporated into the design of the scaffold. Recent advances in manufacturing and material processing technology will enable us to develop scaffolds with organized nanometric architectures and that incorporate controlled growth factor release mechanisms. Techniques such as 3D bio-printing and nanofiber electrospinning will be used to fabricate scaffolds. The ability of the scaffold to attract cells and promote matrix remodelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biochemical and biophysical characterisation of human meiotic cohesin complexes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The cohesin complex is an essential component of mitotic and meiotic chromosomes due to its ability to control the topology of DNA. The core cohesin complex is a ring-like structure composed of two structural maintenance of chromosome proteins plus a kleisin that recruits additional subunits that control the loading and activity of cohesin on DNA. Recent single-molecule approaches show that cohesin displays two primary activities in vitro: ATP-dependent DNA translocation, leading to the formation of DNA loops, and topological entrapment of two DNA molecules, which can explain sister chromatid cohesion. These experiments used cohesin complexes containing the mitotic kleisisin RAD21, but higher eukaryotes express meiosis-specific kleisins, including RAD21L and REC8 in mammals, that are essential for fertility. Although in vivo experiments in mouse and C. elegans suggest that REC8 and RAD21L complexes display functional specialisation, the molecular activity of these complexes remains unknown. The goal of this project is to perform a biochemical and biophysical characterisation of human cohesin complexes containing the REC8 and RAD21L kleisins. To this end, I will combine bulk biochemical approaches with single-molecule methods (TIRF microscopy, optical tweezers) to determine the ATPase activity, complex formation with cohesin regulators (SA3, PDS5, NIPBL), topological DNA entrapment, and loop formation activity of human REC8 and RAD21L complexes. This project will provide mechanistic insights into the mechanisms that ensure fertility in humans.


**Keywords:** Cohesin; Meiosis; Chromosome structure; Single-Molecule imaging; Infertility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NEw Standby Lidar InstrumEnt' in the context of a Sixth Framework call.

assistant: **Objectives**

The aim of the NESLIE project is to develop a 3 axis laser function for air data standby channel for implementation on civil aircraft on the horizon 2010. Actual air data standby channel is composed of individual probes and pressure sensors. Air data standby channels information delivers vital parameters for the safety of the aircraft's flight such as air speed, angle of attack and altitude. But since primary and standby channels have similar failure modes, the use of laser based standby architecture with drastically different failure modes must increase aircraft's safety by reducing the probability of common failures. This technology will also allow to have a nonprotruding probe to measure air speed, angle of attack and slide slip angle in comparaison to traditional probes which have protruding parts subjected to external agressions. NESLIE project main achievements will be : - The design of a Lidar based air data standby system optimized in term of size and weight, allowing at least true air speed (TAS), angle of attack (AOA) and side-slip angle (SSA) measurements. The laser detection range being quite short, from 10 to 100 cm. - The use of guided optics technology (integration on substrate) so as to guarantee compactness and cost reduction. - The design and manufacture of needed technological bricks (ie. separator, commutation, pumps hybridization, low noise detector, low noise power supply) and merge into a minimal number of modules. - A system analysis and definition of sub-systems to be integrated in a standby instrument. - The design and optimisation of an adapted signal processing. - Tests.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cetacean Use of Representational Acoustic Signals' (CURAS).

assistant: **Concept**

This project will determine if dolphins possess representational understanding of individual-specific signature whistles (SW). Dolphin SWs are a created and learned social signal and are thought to function similar to human names. We will examine parallels between dolphin use of SW and human use of acoustic labels which will give us an understanding of representational signalling systems outside of human communication. Research from the host organization has demonstrated that dolphins use innovated and learned contours to address specific individuals, and research conducted by the fellowship applicant has shown that dolphins maintain the memory of these contours for over 20 years. The next step for both programs is to determine if SWs are representational (i.e. do the SWs elicit a mental image of the caller in the minds of the receiver).  Establishing this would show that SWs do function similarly to human names and that long-term memory for these whistles is tantamount to long-term memory for social partners. Furthermore, demonstrating a representational relationship between a signaller and signal in SWs would provide a true understanding of mental representations elicited by signals in a non-humans animal species, something that is extremely difficult to demonstrate in animal communication. To do this, we will first assess the dolphins’ ability to identify conspecifics by gustatory recognition of excreta. Then, using the practice of cross-modal playbacks of sound and chemical cues, we will look for response differences between matches and mismatches of individual identity coded through the two modalities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Identification and characterization of novel genes regulating cell migration'.

assistant: **Objectives**

Cell migration is needed during development of multi-cellular organisms, but it is also involved in pathological conditions, like invasive migration of tumour cells leading to metastases. Conversion of stationary epithelial cells to invasive migratory cells involves changes in transcription, cytoskeletal organization as well as cell signalling pathways.That specific transcription factors are required for cells to become migratory in each system where it has been investigated, emphasizes the importance of transcriptional changes. The migration of border cells during Drosophila oogenesis provides a powerful genetically tractable model to study developmentally regulated invasive cell migration in vivo. The aim of the study is to find novel genes regulating cell migration in order to better understand how cells become migratory in vivo.The proposed project is based on gene expression profiling (microarray) analysis of migrating border cells recently performed in the Rorth lab. The objective of the study is to identify putative regulators of cell migration by targeted gene silencing of candidate genes obtained from the micro-array analysis. The effect of gene silencing will be studied in three different migration models in Drosophila, namely border cells, hemocytes, and recently developed Drosophila model for tumour metastasis. In addition to novel insights into cell migration during development, the results obtained in this study have potential to further our understanding of genes and mechanisms involved in cancer metastasis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Phylogenetic association mapping and its application to secondary metabolite variation in Brassicaceae species' (INTERACT).

assistant: **Innovation**

During the past years, great progress has been made in connecting phenotypes to genotypes based on within-species variation. However, the more dramatic variation that can be found between species has not been explored for phenotype/genotype associations so-far. Using classical genetics to mine between-species variation is mostly impossible, because crosses between distinct species hardly work and their genomes are usually highly rearranged.The goal of this project is to develop unprecedented genomics-based methods for inter-species (phylogenetic) association mapping, which can find signals even in highly re-arranged genomes of different species. To ensure that these methods are also useful in practice, we will apply them to the variation in secondary metabolites within the Brassicaceae plant family. Secondary metabolites are highly variable, genetically controlled, easy to measure and have broad application in cancer prevention, pest control and food design. Given the great potential of phylogenetic association mapping in general and secondary metabolites in particular, our work promises to be ground-breaking and have profound impact on many different fields of genetic research.Specifically, our work plan includes the following points:I) We will develop strategies for phylogenetic association mapping and implement them in publicly-available software.II) We will establish a panel of inbred lines from ~200 Brassicaceae species and generate whole-genome assemblies for each of them. III) We will exemplify the usefulness of phylogenetic association mapping by correlating the diversity of secondary metabolites to the differences in the respective genomes and validate the results by transforming or mutating candidate genes in appropriate species.


**Keywords:** Association ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'MNT Europe Extension'.

assistant: **Innovation**

The FP6/Infrastructure project MNT-Europe (RII3-CT-2004-506231) has led to the creation of a unique distributed platform for research and development in the field of Micro and Nano Technologies (MNT), based on the national facilities of  Léti (F), CSEM (CH), IZM-M and IISB Fraunhofer (D), IMEC (B) and Tyndall (Ir) research institutes. The networking and Joint Research Activities performed during this project have highlighted the strengths and been able to pinpoint the remaining weaknesses of this Alliance.   The basic idea of this proposal is to complete in the most efficient way this integration, based on the experience of this Alliance defined between major partners. Moreover, this will allow in a further step to aggregate new European R&D partners into a very robust core. Basically, three main activities will be dealt with: - a) global management of technical, strategic and commercial joint activities, with both consolidation of common strategy and growth (based on expertise from mixed groups of technical experts, managers and commercial people), and the refinement in the coordination of operation plans (and a two step strategy with respect to the industrial world and  the academic one, in view of future international access activities). - b) developing exploitation of the platform for preparing access to external further partners: this action will deal with solving interoperability problems which occurred during the MNT Europe project, mainly due to the difference in wafers size in use at the different institutes. In order to be able to handle future open access, a central contact point should be created, which allows all partners in the project to access and distribute all incoming contacts.  - c) optimization of internal exchange/operation: this theme will mainly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Oxidation, Lipids, DNA and Mitochondria""' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The overarching aim of the project is to establish a cause-effect relationship among the mitochondrial processes related to ageing in fish (mitochondrial membrane composition, lipid metabolism, ROS production, antioxidant activities, mitochondrial DNA expression), which will advance our understanding of these mechanisms in ectotherms in order to develop a vertebrate model of ageing. The project will require a multi-disciplinary approach utilising molecular biology and biochemistry. Techniques include subcellular fractionation to obtain the mitochondrial fraction, lipid analyses including thin-layer chromatography (TLC) and gas-chromatography (GC) for phospholipid and fatty acid analysis, biochemical assays to assess peroxidation processes, and molecular analyses including PCR cloning of mitochondrial electron transport chain (ETC) cDNAs and gene expression studies to determine tissue distribution and effects of aging using quantitative real-time PCR.The host institution will be the Institute of Aquaculture (IoA) at University of Stirling (Scotland, United Kingdom), a dedicated research Institute with an International reputation in research and post-graduate teaching. The work in the proposed project falls within the remit of the Molecular Nutrition Group at the IoA, a world-leading group in fish lipid and fatty acid metabolism, nutrition and molecular biology.The proposed research project fits very well within the objectives of FP7 of the European Community. The project is part of research efforts that impact on human health through addressing the important issue of the establishment of a vertebrate model of ageing, which would shorten the phylogenetic distance respecting model and the human species. However, the project is also highly relevant to Theme 2 (Food, Agricul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'On-chip energy harvesting and management enabled by Thermal engineering of two-dimensional MAterials'.

assistant: **Concept**

Two-dimensional (2D) van der Waals layered materials have been acclaimed for their great potential in several fields of condensed matter physics. As applications are starting to appear, increased effort is dedicated to understand their unique electronic, optical, mechanical and chemical properties. However, thermal and thermoelectric (TE) properties of 2D materials remain largely underexplored despite their profound potential impact on one of the most important current scientific and technological challenges: energy management. TheMA is an ambitious project, which aims to create a breakthrough in our understanding and ability to control phonon and energy transport at the nanoscale. Its main goal is to create novel 2D semiconductor nanomaterials and heterostructures for thermal management applications and TE devices for power generation beyond current state-of-the-art. Specifically, by using phonon engineering approaches supported by advanced characterization, the project targets the fabrication and on-chip integration of (a) novel engineered transition metal dichalcogenide (TMD) based nanostructures for heat guiding and superior thermal insulation and (b) TE power generators capable of recycling the waste heat from hot spots or environmental interlinks, to deliver sufficient power to sustain low-power electronics. Ultimate goal of the project is to provide innovative solutions for on-chip energy management and energy harvesting for Information and Communication Technologies, the Internet of Things and 2D nanoelectronic devices.The research proposed here will go beyond state-of-the-art providing the in-depth understanding of nanoscale energy dissipation and phonon transport in 2D nanomaterials and lay the foundations for the development of future three-dimensional hetero