RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Semliki forest virus based therapeutic systems'.

assistant: **Concept**

SFV based systems are increasingly the virus vector systems of choice for production of recombinant proteins for research, therapy and diagnosis. They have also been used as the basis for vaccines for a number of pathogens and recent studies indicate that they could be important systems for gene therapy and cancer therapy. For each of these uses the current system has limitations, which could be modified by engineering the viral replicas gene and by targeting to specific cell types. Work on SFV systems has been an exclusively European effort and this project will combine the expertise of the principal EU laboratories. The aim is to research, design, engineer, and test and delivers a new generation of SFV systems for research, biotechnology, vaccination, gene therapy and cancer therapy. These systems will have many important uses in biology, medicine and veterinary medicine and make an important contribution to the quality of life in Europe and worldwide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Multi-instrument analysis of Rosetta data – Establishing a new paradigm for cometary activity'.

assistant: **Concept**

The MiARD project will use a wide range of data sets from the Rosetta mission (including the Philae lander) to refine the 3D topography of specific areas of comet 67P/Churyumov-Gerasimenko, to study the activity and changes caused by subliming volatiles as the comet nears the Sun, to make inferences about the nature of the top 10 cm of the surface of the comet, to assess whether the landing site on the comet is representative of the entire comet, and to create an improved outgassing model. The new knowledge will be used to improve models of cometary orbits and dust generation in order to allow better hazard assessment.A strong emphasis will be placed upon  public communication activities, making full use of the visual nature of the data products to be produced by the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeting OGG1 in Idiopathic Pulmonary Fibrosis' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease with no curative therapies. Approved therapies for IPF have a high rate of discontinuation among patients due to adverse side-effects and present a high unmet need for effective therapies. Oxcia’s OXC-201 is a ground-breaking novel approach for treatment of IPF, based on completely new biology. OXC-201 targets profibrotic and proinflammatory cascades at an early stage on a transcriptional level, and is expected to efficiently prevent lung damage, creating a window for restorative processes to repair scar tissue. OXC-201 has demonstrated significant efficacy in halting disease progression and improved safety and tolerability in preclinical IPF models. In the TOPFIBRO project we will 1) obtain further proof of concept of OXC-201’s efficacy in improving lung function in vivo and confirm antifibrotic efficacy in patient-derived ex vivo models compared to current standard of care, 2) take OXC-201 through preclinical safety assessment studies, 3) fulfill regulatory demands, preparation of IMPD, CTA and ethical applications in order to initiate first-in-human studies, 4) perform first-in-human clinical studies to determine safety profile in healthy volunteers, 5) develop a strong business plan with regulatory, financial and clinical roadmaps to improve investor-readiness. These steps will allow us to further develop OXC-201 with the end goal of bringing it to market via a licensing deal with a large pharmaceutical company. OXC-201 has the potential to fill a large unmet need of the IPF patient community and present the first potentially curative therapy.


**Keywords:** Lung disease, OGG1 inhibitor, drug development, anti-fibrotic, prevent lung damage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Galaxies through the cosmic ages: the role of primordial conditions and environmental effects' (STGDELUCIA2007) targeting Seventh Framework.

assistant: **Abstract**

The observed properties of galaxies have long been known to depend on the environment in which they are located. The physical origin of the observed environmental trends is, however, still a subject of debate. Much of the argument centres on whether these trends are the end products of physical processes acting over the entire lifetime of a galaxy (the nurture hypothesis), or whether they are established at formation (the nature hypothesis). One element is often overlooked in this debate: according to the current paradigm for structure formation, dark matter collapses into haloes in a bottom-up fashion. Small objects form first and subsequently merge into progressively larger systems. As structure grows, galaxies join more and more massive systems, and so experience a variety of environments over their lifetimes. Thus both initial conditions and subsequent physical processes must play a role in shaping the observed properties of galaxies, and their variation with environment. Here I propose a detailed investigation of the relative roles of various physical processes, and of conditions at formation in determining the observed environmental trends. The work will exploit synergies between different theoretical methods, and will involve detailed comparisons with observational data from spectroscopic and photometric surveys at both low and high redshift. The results should provide the first quantitative estimate of the relative importance of nature and nurture in determining the observed environmental trends within the current standard picture of structure formation. In addition, results from this study will be of important guidance for interpreting data from ongoing and planned surveys, and will provide precious and timely tools for the preparation of key programs and surve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Technical development of open, economic and friendly system for the injection moulding process control' (1998-2002).

assistant: **Innovation**

The objective of this Craft project is the development and implementation of an operating system which will enable us to create a modular multi-level architecture integrated and open control system, for injection. Moulding plastic machines, manufactured with low-cost standard components, to replace the hardwired systems currently in use. Similar to the evolution of personal computers, our aim is to develop a multi-level architecture modular system, with the objective of separating the hardware (injection-moulding) and the software (control) and permitting low-cost standard components (PLCs)a to be used. Such systems will be completely open (Windows environment) programmable, adaptable to the company's and/or customer's operating system, with a user-friendly environment that will be the same for all the companys machines, in accordance with EUROMAP^b guidelines, and with minimum, affordable maintenance. An injection-moulding machine is a system useful to perform a series of automatic operations. It dispense the material through the turn of a screw, inject and compact the material through a forward movement of a screw and finally open and release the piece through programmable movements of an interlocking device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Individually configurable automatic cost calculation system for 3-d laser cutting (ICACOST)'.

assistant: **Objectives**

At present, small and medium-sized enterprises (SME's) in the sheet metal industry have to invest much time in At present, small arid medium-sized enterprises (SME) of the sheet metal industry have to invest much time in offer preparations, because of the low probability of getting the job. The offer calculation is mostly done manually as an estimation. For example, the length of the contours to be cut are extracted from drawingsand summed up. Actual production time for workpiece problem areas like sharp angles and narrow radii can only be calculated by a post-prossesor simulation or by a comparison with a similar workpiece that was manufactured before. This complicates the cost calculation and adds an unsureness factor to calculation. Therefore, only experienced employees can estimate the costs for the cutting of 3-d workpieces. The aim of the proposed software ICACOST is the quick and automatic cost calculation for 3d laser cutting. Less experienced persons shall be able to use the configured tool. Therefore, characteristic numbers are generated on the basis of the workpiece geometry. They describe all necessary machine work to perform and the workpiece specific problem areas. As next step, the dynamic machine behaviour for these problem areas is projected to specific machine parameters. By connecting the characteristic numbers with the machine parameters, the machining time for a specific machine is calculated. This machining time is an important factor for the cost calculation. The characteristic numbers are also used to find similar workpieces within the planned offer database. This database is also implemented during the project and contains all created offers. As plausibility check the user can search for similar offers and compare them with the new one. A comple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The steel industry, circularity and the stock-flow-service nexus' (CircNexSt), addressing dissemination and exploitation.

assistant: **Impact**

Steel is the world’s most recycled metal, yet only 21% of the global demand is met through scrap, which highlights the gap between the present reality and the ideals embedded in the concept of the circular economy. The latter is designed to increase material recoverability and product optimisation throughout the entire life cycle, resulting in less carbon emissions, waste and resource dependency. Within the steel industry, leading companies and professional bodies have sought to promote and embody the circular economy to advance sector sustainability.This project will use the Stock-Flow-Service (SFS) Nexus to quantify the circularity of an international steel company’s products from extraction to service. The SFS nexus is a conceptual framework that explicitly highlights the interactions, including trade-offs, between energy and material flows (e.g. coal, iron ore), material stocks (e.g. buildings, vehicles) and service provision (e.g. shelter, mobility). By applying this nexus, one can assess the overall environmental performance of a light weighting strategy by juxtaposing reduced fuel consumption and carbon emissions with the increased incorporation of complex material composites. The latter make energy savings possible but are difficult to re-use and recycle, thus reducing the circularity of the process.The project will use Material Flow Analysis and Dynamic Stock Modelling to quantify resource consumption and accumulation linked to the service provided by steel. A set of resource efficiency and circularity indicators will be developed to evaluate the environmental performance of steel products (and prototypes) under various business strategies, including stock optimisation, green leasing, and product-service systems. The project’s results and recommendations will s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of nf-kb in the regulation of apoptosis' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content When cells are exposed to tumor necrosis factor (TNF) two antagonistic pathways are induced: apoptotic and other anti-aptototic. The latter is mediated by the transcription factor NF-KB which is a central mediator for the gene expression induced in cells by pathogens or inflammatory cytokines, and is known to play an important role in development of the immune system. It has been recently shown NF-KB activates an anti apototic response by inducing gene transcription. The aim of our experimental work is to isolate and characterise NF-KB-inducible genes whose protein products have an anti-apoptotic function. Training content (objective, benefit and expected impact) To achieve our objectives, a TNF responsive cell line containing an inducible inhibitor of NF-KB will generated. When the NF-KB inhibitor alpha (a transdominant negative version resistant to signal induced proteolvsis) is induced and the cells exposed to TNF, apotosis will be triggered. In the absence of inhibitor, NF-KB will be induced and transcription of the anti-apoptotic genes will protect the cell from the TNF induced apoptosis. Comparision of the mRNA populations in the presence or absence of IkBa should permit identification of NF-KB inducible genes. Cells expressing the IKBa mutant under negative control of the tetracycline (tet) represor will remain viable in the presence of tet (NF-Kb activated), but will become apoptotic in the absence of tet (NF-KB inhibited). Once an appropriate cell has been identified it will be exposed to TNF and PolyA+ RNA extracted from cells which have expressed the transdominant IKB inhibitor and viable cells in which NF-KB is activated due to repression of the inhibitor gene. mRNAs induced by NF-KB will be isolated by subtractive hybridizati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innervation-driven mechanisms of bile duct development' (2021-2027).

assistant: **Innovation**

While liver development is well-studied, the signal initiating tubulogenesis of bile ducts therein remains to be identified. Neurites are present in the liver before bile duct tubulogenesis, and in other organs, innervation can instruct tubulogenesis. However, a role for liver innervation in biliary tubulogenesis has not been shown. Preliminary data from my host lab suggest a strong link between both processes: Defective biliary tubulogenesis caused by Notch mutations in Alagille syndrome (ALGS) is preceeded by a lack of liver innervation. I will test the hypothesis that intrahepatic innervation initiates biliary tubulogenesis.   First, I will apply 3D staining and imaging techniques to study the establishment of intrahepatic innervation at multiple timepoints during development, and quantify characteristics of innervation in healthy and ALGS mice in depth using automated image analysis. Secondly, I will investigate if liver innervation is required for tubulogenesis by performing nerve ablation studies and analyzing its effect on biliary cells. Finally, I will establish a method to perform transcriptional profiling of liver innervation. The liver is only innervated by nerve endings from extrinsic neurons, and these neurons have their cell bodies in ganglia outside of the organ where also other neurons reside. It has thus not been possible to isolate these cells from the liver and analyse their expression profiles. Using a viral barcode library to label neurons and their axon endings, I will perform single-cell RNA sequencing on those ganglia, and identify and characterize the cells innervating the liver.  Enabling expression profiling of extrinsic nerves will be a game changer in the field of organ innervation, and can be applicable to numerous other fields. This projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative and effective technology and logistics for forest residual biomass supply in the EU' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

INFRES aims to accelerate the technological development and open new paths to EU’s renewable targets by producing research based knowledge, technological solutions and service innovations for forest residue feedstock supply. INFRES aims at high efficiency and precise deliveries of woody feedstock to heat, power and biorefining industries by: Producing technological and logistic innovations for developing new harvesting, transport and storage technology for forest fuel procurement,  Demonstrating new solutions in full supply chains from harvesting to transport and storage in real operational environment Spotting the technological, economic, regulatory and other bottlenecks in the innovation structures for the forest energy sector, Assessing the environmental, economical and social sustainability for the developed logistics including scenarios for different fuel sources, methods, technologies and transport distances and  Disseminating the outcomes of research and demonstrations to the practices.Project consortium has 23 partners including 9 leading forest energy research organizations of accompanied with 14 SME along the biomass supply chain. SME’s include manufacturers of harvesting technology, chippers, feedstock supply enterprises, forest harvesting and transport providers, truck technology and IT service provider to manage fleet and storages. During the project INFRES develops and demonstrates technological and logistical solutions that decrease the fossil energy input in the biomass supply by 20% and reduces the raw material losses by 15%. The cost of supply can be reduced by 10-20% and precision of supply improves the economic outcome of CHP production by 10%. The CO2 emissions of feedstock supply will diminish by 10%. With the novel technologies and efficient trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LUMI AI Factory - Advanced experimental AI-optimised quantum based platform' (LUMI-IQ).

assistant: **Concept**

As AI technologies and methodologies continue to advance swiftly, Europe has been actively developing and strengthening the ecosystem of frameworks, environments, tools and services required to boost innovation. This comprehensive approach aims to harmonise AI strategies across the continent, addressing the technology’s challenges and opportunities, while assessing its impact on public and private sectors, and society at large. Leveraging the ongoing momentum and LUMI’s successful history, the Finland led consortium responds to the HORIZON-JU-EUROHPC-2025-AI-01-IBA-02 call by introducing the LUMI AI Factory - Advanced experimental AI-optimised quantum based platform or LUMI-IQ, part of the broader LUMI AI Factory ecosystem, to be procured and installed together with the LUMI-AI supercomputer and leveraging the LUMI AI Factory Service Center.


**Keywords:** Artificial intelligence, Quantum computing, AI-optimised supercomputer, experimental platform, AI Factory