RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Strengthening global cooperation and institutional capacities in sub-Saharan Africa to facilitate implementation of the GH EDCTP3 programme' under Horizon Europe.

assistant: **Concept**

This proposal is in response to the GH EDCTP3 call for support to EDCTP Africa Office (AO), which is part of the EDCTP Association Secretariat, based in Cape Town and hosted by the South African Medical Research Council. The aim of the proposal is to provide support for the operation of the AO to ensure  optimal implementation and visibility of the GH EDCTP3 programme in SSA. The AO will  provide technical support, promote networking activities (South-North, South–South), ensure alignment of the funded activities, strategic partnerships, and increase visibility of the GH EDCTP3. This aim of the project will be achieved through several activities that include technical support for the design, implementation and monitoring of capacity developing activities, monitoring funded projects, organising workshops, and facilitating dialogue between African and European research entities and stakeholders. The expected impact is a strengthened and improved delivery of the GH EDCTP3 programme in SSA. The implementation of this proposed project will be structured into four work packages (WP) called Project management (WP1), Capacity development and networking (WP2), Strategic Partnerships (WP3) and Conferences, forums, and meetings (WP4). Through this grant the AO will contribute to the following impacts: Accelerated product development for fighting target infectious diseases; Facilitated preparedness against public health emergencies in line with One Health; Increased visibility of AU-EU partnership in science; Ensured close alignment with SSA national research programmes and activities on target diseases and R&I; Increased participation of SSA countries in GH EDCTP3; and Increased participation of industry and private entities in product development and clinical trials in SSA.  To i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural and biochemical studies on the regulation of transcription during elongation' (TRANSREG).

assistant: **Innovation**

During the first step of gene expression, a universally conserved enzyme called RNA Polymerase (RNAP) transcribes RNA from a DNA template in every cell. Transcription is a fundamental, yet incompletely understood process. Because of its central role, the bacterial transcription machinery is also a prime drug target. Crystal structures of RNAP core as well as RNAP elongation complexes (ECs) have revolutionized our understanding of transcription. This groundwork paved the way to address more complex questions regarding the regulation of transcription. Transcriptional regulation impacts every aspect of biology including a growing list of human diseases. Transcriptional pausing, a temporary interruption of transcription during elongation, plays a major role in regulating gene expression in pro- and eukaryotes. A full and mechanistic understanding is crucial and requires a combination of structural and biochemical studies. This is where the proposed work will contribute. Our goal is to understand how transcription factors modulate RNAP during the elongation phase.Biochemical and structural approaches (X-ray crystallography and single particle cryo-EM) will be used to gain detailed insights on the regulation of transcription by protein factors and non-coding RNAs (ncRNAs). To complement the results, an experimental system will be established using Fluorescence Resonance Energy Transfer (FRET) to study the dynamics of RNAP. This system will allow us to address questions concerning RNAP dynamics during processes that regulate transcription. Specifically, we propose 3 aims:1.: Investigate the role of transcription elongation factors that modulate RNAP pause behavior and couple transcription and translation2.: Study the role of RNAs that regulate transcription3.: Establish an exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A FAST AND ECO-EFFICIENT TRANSHIPMENT SYSTEM FOR ULTRA LARGE CONTAINER VESSELS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The aim of the project is the design of an integrated intermodal system ideally suited for fast loading/unloading of the new Ultra Large Container Vessels and the subsequent fast terminal stowage of the containers. The proposed container terminal includes two major innovative concepts: a) a small number of indented berths for accommodating the new ULCVs which are handled by new multi-trolley portal container cranes enabling fast loading and unloading from both sides of the ship and b) a multi-level container terminal with ground running lanes, elevated container flow roadways and an innovative system for placing hatch covers. The above arrangement is proposed in combination with ordinary line quays with conventional container cranes for accommodating the smaller vessels.The business plan will include description of the new system, its equipment and operations, market analysis, logistics details, description of human resources, environmental benefits, financial risk assessment, calculation of costs and cash flows from sales of services, funding sources, NPV and IRR of the investment, payback period, effect of the new system on local economies, savings in electricity, fuel, wages, and increase in annual throughput capacity among various parties and stakeholders. Detail studies are going to be carried out in phase 2, providing results for the dimensions of the new portal cranes, their aerodynamic profile and connections and optimising container stacks and roadways around the indented berths and the use of automated systems.The completion of the project will provide a solution to the limitations of the existing container terminals to cope with the new ULCVs and will free the design of the ULCVs from limitations imposed by the capabilities of the current loading/unloading me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Female Leadership and Effects from African Droughts'.

assistant: **Innovation**

Fem-LEAD challenges present scholarship by proposing a new link between climate change and gender: What if weather-related disasters, such as droughts, risk hurting recent advances of women as political leaders in African countries? Focusing on droughts, public opinion and political representation, its objective is to gain theoretical and empirical insights of links between weather-related disasters and womens political standing. I pose two major questions; Q1. How and why do droughts affect the citizen demand for female politicians? Q2. How and why do droughts affect the supply of female candidates and the presence of elected women?I develop and test theoretical expectations in two directions; First, on citizens demand for female leaders (Q1). This vein is investigated through three rigorous methods: I analyze observational data where geocoded information on droughts is connected to survey respondents across Africa and over time. Exploring mechanisms, I focus on South African drought-affected communities, using in-depth interviews. To test causal mechanisms, I implement creative survey experiments with information treatments on droughts and candidate preferences. Second, I study the electoral arena (Q2). I focus on droughts and local elections across African countries and especially on South Africa, with a unique complete register of candidates and representatives across wards for two decades. I also interview party gatekeepers and, finally, look at aggregated trends across countries.I build on my long publication record and local network in the field. Having conducted pilot-studies, the inquiry of Q1 is feasible yet novel. Having access to high-quality data  that no one has analyzed  the study of Q2 promises groundbreaking findings. Fem-LEAD will result in a new theor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Designing Inclusive Products with Image Schemas' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

By 2020, one in every two European adults will be over 50 years in age. As old age brings along reductions in sensory, cognitive, and motor abilities, product development methodologies have to adjust. While sensory and motor abilities are relatively straightforward to measure, cognitive abilities are more elusive. The proposed project is concerned with developing and testing a framework model of cognitive abilities that helps practitioners in designing more inclusive products. The goal is to minimise the number of people excluded from or who experience difficulty with using mainstream products. More specifically, the objectives are (1) to develop an integrated framework of cognitive functioning for inclusive design, (2) to test the predictions of this framework for different products and verify their fitness for practical purpose, and (3) to derive and evaluate practical guidance that results from this framework and from the empirical findings. The integrated framework combines a traditional model of human cognition with image schema theory – an account of subconscious knowledge representation that predicts to be useful for inclusive design. The project allows extending the fellow’s previous research on image schemas in the domain of inclusive design for which the host institution has a renowned expertise. The new competencies acquired by the fellow during his stay in the host institution will contribute to the development of his scientific career and future research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synthesis and Biological Evaluation of Pyrroquinoline Pseudo-Natural Products' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Natural products (NPs) and their structural scaffolds are a rich source of small molecule tools for chemical biology and drug candidates. In a novel approach, this proposal will investigate the combination of natural product fragments to form pseudo-natural products (pseudo-NPs) with uncharted biological activity. The purpose of this project is to explore the diastereo- and enantioselective synthesis of two pyrroquinoline scaffolds, a combination of pyrrolidine and tetrahydroquinoline fragments, and submit the obtained compound collections (>100 compounds) to phenotypical screening assays to assess their biological activity. The obtained molecules could potentially serve as novel biological probes and lay the foundation for the discovery of novel targets or drugs. Highly active compounds will be used to establish structure activity relationships (SAR) and design affinity isolation probes for the identification of cellular targets.


**Keywords:** Evaluation of biological activity, Stereoselective Synthesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Enabling Science and Technology through European Electron Microscopy'.

assistant: **Concept**

ESTEEM2 is an integrated infrastructure of electron microscopy facilities providing access for the academic and industrial research community in the physical sciences to some of the most powerful characterization techniques available at the nanoscale. Transnational access to ESTEEM2 centres is obtained through a transparent, simple peer review process based on merit and scientific priorities. Service to users is supported by a networking programme which addresses key issues such as specimen preparation, data interpretation through theory and simulation, and standardization of protocols and methodologies. A series of schools and workshops provide training in innovative methods in electron microscopy and a forum for discussing emerging (cutting-edge) techniques. Directed research programmes focus on the further development of electron diffraction, imaging and spectroscopy and the advancement of 3D methods and time resolved experiments. In all, ESTEEM2 establishes a strategic leadership in electron microscopy to guide future developments and promote electron microscopy to the wider research community at large.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Function, role, and control of gigantic bacterial roll' (Fun-ContRoll).

assistant: **Concept**

R-bodies are probably the largest organised intracellular proteinaceous structures in bacteria. They adopt a roll-like structure that occupies almost the entire cellular volume. Upon acidification, R-bodies extend telescopically up to 20 micrometres. First discovered in endosymbiotic bacteria, they were proposed to eliminate symbiont-free hosts, however their mechanism of toxicity remained unexplored. In addition, structures of similar composition and activity form ejectile defence organelles in Cryptomonads. Recently, we found that free-living environmental bacteria from the phylum Bacteroidota also produce R-bodies. In the Fun-ContRoll project we will study the assembly and conformational change mechanisms of these structures. We will investigate their mechanism of action and ask whether it depends on the extension or delivery of associated toxic effectors. To understand their biological role, we will explore hypotheses about their costs and benefits to the bacterial cell and to population. Alternatively, we will assess their role in establishing and maintaining the symbiosis. We will evaluate whether their biological role has pathogenic potential or, on the contrary, could help to eliminate parasitic species that cause disease and spread pathogenic bacteria. Finally, we will try to understand the strict regulatory mechanisms that controls the heterogeneity in the population, leading to a well-defined fraction of the population that produces these giant structures.


**Keywords:** symbiosis, inclusion bodies, organelles, macromelcular complexes, bacterial toxins, bacterial defense systems, population heterogeneity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PLAnar Technology for Optical Networks' to be submitted under Fifth Framework.

assistant: **Abstract**

The aim of this project is to thoroughly study, develop and assess photosensitive planar technology in a system context, through key devices for future optical metropolitan networks. Selected devices are multi-channel Optical Add and Drop Multiplexers (OADM) where any wavelength (or waveband) is added/dropped among several wavelengths (or wavebands). Re-configurable operation is ensured through the use of thermo-optic switches. Where today three components are required for de-multiplexing, routing and multiplexing, here a single component is needed. Beyond a major advance in terms of switched granularity, this device offers the excellent spectral efficiency of Bragg gratings. All aspects are covered: planar waveguide process, UV writing (grating, waveguide), characterisation of underlying mechanisms, thermo-optic switches, devices design and realisation including packaging, as well as system tests and assessment.Objectives:The overall objective is to thoroughly study, develop and assess in a system context photosensitive planar technology, through key pilot devices, ensuring an optimal development.Objectives are three fold:(i) to establish an optimised process suitable for devices realisation;(ii) to produce and optimise, under systems specifications, key pilot components which are representative of the potential of this technology, and are advantageously realised through it;(iii) to provide system assessment of the devices performances, and more generally assess the potential and impact of this technology on photonics networks.Work description:The technical approach is based on the close relationship between four main tasks:1/ System specification and evaluation: to define devices specifications, to characterise devices in system tests representative of their functiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Assessment of grazing impact on desertification risk in mediterranean rangelands' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

GrazeMed will provide multiple benefits to fellows. In addition to being exposed to the past and on going research projects on the ecology and management of the Mediterranean rangelands of the MCTC, they will learn novel methods for estimating the grazing impact on rangelands by using modern ecological theory such as the fractal diversion, information dimension and developmental instability. They will also learn various software such as Visual Basic, Maple V, SPSS and SAS as well as image analysis. Moreover, they will get trained in vegetation sampling by using PSION, GPS and digital calliper. Finally, they will have the opportunity to learn remote sensing and GIS and use these techniques in analysing the structure of landscapes and producing thematic maps for management purposes. In the meantime they will interact with other graduate students while being supervised by experienced researchers and faculty members.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards the detection of the axion with the International Axion Observatory' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The nature of the Dark Universe is an outstanding question in modern science, and is connected with our understanding of the reality at the most fundamental level. Despite the enormous success of the Standard Model (SM) of particle physics, a number of shortcomings of the theory and the fact that it does not account for the Dark Matter and Energy, prompt theorists to propose possible hypothetical extensions. Some of these extensions predict the existence of very-light and very-weakly-coupled axions (or axion-like particles, ALPs). Recent theoretical and phenomenological work is sharpening the physics case of these particles. They are now considered as very motivated portals for physics beyond the SM, and in particular as very plausible Dark Matter candidates. In addition, some intriguing astrophysical observations might be interpreted as hints for their existence. The International Axion Observatory IAXO is one of the most ambitious proposals to find the axion. Its baseline configuration relies on the search for solar axions, but could also host relic axion detectors. IAXO will go well beyond current experiments' sensitivity and will probe a large fraction of the -still unexplored- parameter space of the axion and ALPs. The scope of the present proposal encompasses the realization of a first complete intermediate experimental stage, BabyIAXO,  including prototypes of the IAXO magnet and detection systems. It will already provide relevant physics outcome in the time-frame of the current grant, while preparing the ground for, and extending the physics reach of, the full IAXO. In particular, BabyIAXO will already be able to test a number of axion and ALP models that are invoked by the aforementioned astrophysical hints and therefore already at this stage there is potential