RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Uncovering the molecular effects of the tubulin code and their impact on organism-wide functions' (TubulinCode) targeting Horizon Europe.

assistant: **Abstract**

Microtubules (MT) are core components of the eukaryotic cytoskeleton with essential roles in cell division, cell shape, intracellular transport, and motility. Despite their functional divergence, MTs have highly conserved structures made from almost identical molecular building blocks  tubulin proteins. A variety of posttranslational modifications (PTMs) diversifies these building blocks, which is thought to control most of the properties and functions of the MT cytoskeleton, a concept referred to as the tubulin code.While they appear to have subtle effects at the molecular level, tubulin PTMs are essential for maintaining cellular functions of MTs over large spatial and temporal scales. Yet, a comprehensive knowledge of the principles of the tubulin code, connecting its functions across the molecular, cellular and organismal levels, is almost entirely lacking.Our project aims to obtain a novel molecular and mechanistic understanding of how tubulin PTMs control long-term cellular function and homeostasis. Our unique approach bridges all relevant scales of biology and relies on a synergy between our powerful experimental models and expertise in biochemistry, structural biology, single-molecule assays, systems-biophysics, cell biology, and physiology.Specifically, we will: (1) Determine how different tubulin PTMs affect biophysical and structural properties of MTs and their interactions with associated proteins; (2) Define the impact of tubulin PTMs on overall MT cytoskeleton behaviour and the resulting physiological implications in neurons; (3) Combine zebrafish and mouse models and develop a novel fish model for lifelong in-vivo imaging to determine how the tubulin PTMs control lifelong MT-based functions.Our work will define the importance of tubulin PTMs by revealing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Magnetism and Optics for Nanoparticle Catalysis' under Horizon 2020.

assistant: **Concept**

MONACAT proposes a novel approach to address the challenge of intermittent energy storage. Specifically, the purpose is to conceive and synthesize novel complex nano-objects displaying both physical and chemical properties that enable catalytic transformations with a fast and optimum energy conversion. It follows over 20 years of research on “organometallic nanoparticles”, an approach of nanoparticles (NPs) synthesis where the first goal is to control the surface of the particles as in molecular organometallic species. Two families of NPs will be studied: 1) magnetic NPs that can be heated by excitation with an alternating magnetic field and 2) plasmonic NPs that absorb visible light and transform it into heat. In all cases, deposition of additional materials as islands or thin layers will improve the NPs catalytic activity. Iron carbides NPs have recently been shown to heat efficiently upon magnetic excitation and to catalyse CO hydrogenation into hydrocarbons. In order to transform this observation into a viable process, MONACAT will address the following challenges: determination and control of surface temperature using fluorophores or quantum dots, optimization of heating capacity (size, anisotropy of the material, crystallinity, phases: FeCo, FeNi, chemical order), optimization of catalytic properties (islands vs core-shell structures; Ru, Ni for methane, Cu/Zn for methanol), stability and optimization of energy efficiency. A similar approach will be used for direct light conversion using as first proofs of concept Au or Ag NPs coated with Ru. Catalytic tests will be performed on two heterogeneous reactions after deposition of the NPs onto a support: CO2 hydrogenation into methane and methanol synthesis. In addition, the potential of catalysis making use of self-he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Second intercomparison for ochratoxin A in pig kidney' in the context of a Fourth Framework call.

assistant: **Objectives**

Ochratoxin A is a mycotoxin produced by Penicillium and Aspergillus species. It is reported to be a genotoxic carcinogen. Transfer of ochratoxin A from feed to edible animal products, particularly pig kidney, has been demonstrated. Reliable analytical techniques for the determination of ochratoxin A are essential for establishment and enforcement of tolerance levels. A first intercomparison study of methods for the analysis of ochratoxin A in pig kidney highlighted problems in the areas of spiking and extraction of ochratoxin A from freeze dried pig kidney material. The inadequacy of analytical procedures as demonstrated by this first intercomparison study; together with the need for certified reference materials, led the European Union SMT programme to undertake a second intercomparison study for ochratoxin A in pig kidney.The main aim of this second intercomparison study is to improve methods for the determination of ochratoxin A in pig kidney.Particular objectives are:- To address the reconstitution, spiking and extraction problems experienced in the first intercomparison study;- To develop a method for ochratoxin A in pig kidney compatible with immunoaffinity column clean-up;- To hold a second intercomparison study of methods for the determination of ochratoxin A, including the use of immunoaffinity columns.The ultimate aim is to produce a certified reference material for analysis of ochratoxin A in pig kidney.A reconstitution and spiking procedure has been developed with all participants will be required to follow. Investigations into extraction efficiency have indicated that use of a stronger acid in the extraction solvent (lower pH) may increase the amount of ochratoxin A extracted from the freeze dried pig kidney. Therefore, the second intercomparison study will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Diabeloop to Patients: An Artificial Pancreas solution to improve the balance, safety and autonomy of 20 million people' (D2P).

assistant: **Innovation**

20 million people worldwide are affected by type 1 diabetes (T1D), an autoimmune condition leading to the destruction of beta cells of the pancreas producing insulin.  T1D causes severe complications: short terms - seizures and fainting that could result in coma or even death; long terms -  blindness, amputations, renal failure, heart diseases. T1D can occur to anyone and half of the cases begin before age 20.  T1D patients have to manage their diabetes on a daily basis, facing countless stressful situations.Diabeloop’s “artificial pancreas” solution aims to mimic the glucose regulating function of a healthy pancreas. The core of our “artificial pancreas” solution is an artificial intelligence: algorithms based on physiological models continuously calculate the most appropriate and personalised dose of insulin. Insulin is then automatically delivered to the patient. Diabeloop goals are to reduce hypoglycaemia and hyperglycaemia periods, alleviate the day-to-day burden and avoid long-term complications.Diabeloop’s first generation solution (DBLG1) is integrated in a closed-loop system made of three components: a continuous glucose monitoring sensor, a connected insulin pump, and a handset hosting algorithms and controlling the pump. Diabeloop’s solution integrates a telemedicine program through highly secured data exchange, storage and healthcare professional identification. Clinicians may access the patients’ data and suggest treatment adjustments as necessary, for an improved system customisation and long-term regulation.During the phase 2 project, we scale up and target a European adoption of our breakthrough innovation. We focus on France, the Netherlands and Sweden, 3 countries with complementary specificities to validate our model: adaptation of the device to forei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Living in Europe in the late Neolithic: A trans-disciplinary temporal perspective on present-day Europeans' (NEO).

assistant: **Innovation**

The genetic landscape of Europe has been extremely dynamic through time, in particular during the Neolithic transitions, and is thus difficult to redraw from the analysis of present-day populations only. Our understanding of the population migrations and cultural diffusion processes underlying the peopling of Europe has greatly advanced with recent developments in ancient DNA high-throughput sequencing. Surprisingly, despite the presence of large Neolithic human groups and its geographic location bridging Southern and Northern Europe, France is extremely under-represented in current Neolithic genomic dataset. Moreover, most recent studies focus on population migration at a global scale only, while epigenomes and oral microbiomes, which are impacted by external factors and influence the individual health and phenotype, can now be retrieved from ancient DNA sequences. NEO proposes to apply a multidisciplinary approach combining the latest advances in physical anthropology, isotopic methods, ancient genomics, metagenomics and epigenomics to two exceptional Neolithic human groups from France (Cave I of Treilles and Mont Aimé). NEO will enable us to decipher not only migration patterns and genetic ancestry, but also important aspects about life in past society, such as residential rules, funerary practices, health and diet. The success of NEO will be based on the excellent synergy between the experienced researcher and the host institution, as the applicant will benefit from state-of-the-art facilities and expertise to gain advanced training in physical anthropology methods, while applying her genomic skills to a sample set available at no other research institution in the world. By acquiring these new skills in an international context, the experienced researcher will becom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Financial Institutions and Regulation for Development', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

This proposal consists of three empirical projects to advance our understanding on the specific conditions and frictions faced by financial institutions operating in low and middle-income countries. Understanding these aspects is crucial to elaborate policies of financial regulation and government intervention that promote structural transformation and development.1. Ethnic Banking and Central Bank Independence. This project plans to study the political economy frictions behind financial regulation in Africa. Combining bank balance sheets and information on bank chief executive officers (CEOs), we will measure the ethnic connotation of banks and the co-ethnicity between CEOs and regulators. We will investigate the existence of ethnic favoritism in banking, the political use of financial regulation and the role of central bank independence in alleviating this friction.2. Branch Organization, Multiculturalism and Conflict. Organizations decide their internal hierarchy considering the tradeoff between the use of knowledge and the internal frictions in communication and coordination. These frictions may be particularly high in the presence of a multicultural workforce and if conflict exacerbates within-organization differences. Building new data on hierarchy and management practices among Ethiopian bank branches and an experimental survey of lending discrimination, we plan to study the effect of conflict on the internal organization of banks, their hierarchy and effects on lending markets.3. Market Incompleteness and Non-Performing Loans (NPLs). Structural transformation implies a move from low to high-productivity sectors. However, incomplete markets prevent banks from selling loans from low-productivity sectors and instead oblige banks to hold NPLs, depressing the financi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Processes using sub- and supercritical fluids' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The researcher can take part in the following research programme: - extraction / fractionation of active components from natural materials;- solubility determinations of solids and liquids in dense gasses (CO2, propane, butane, dimethylether) by static analytic or a flow method;- determination of the S-L-G equilibrium curve of a solid component in the presence of a compressed gas;- modeling of phase equilibrium data by density based correlations or by equations of state in binary and ternary systems;- mass transfer studies and modeling of extraction curves;- study of enzyme(s) residual activity in dense gases;- enzymatic reactions in dense gases (esterifications and hydrolysis, protein synthesis and hydrolysis, enzyme-catalyzed resolution of chiral compounds) in high pressure enzymatic batch stirred tank and continuous packed bed reactor, where reactions can be catalyzed by immobilized or native enzymes. The use of native enzymes can also be performed in the continuous stirred membrane reactor, with integrated reaction and separation zones; - materials processing using dense gasses, which is one of the most attractive use of supercritical fluids today which gives high added value products with completely new properties, which can be influenced by the process parameters. PGSS process has many advantages over other processes for fine particle formation: versatile process applicable for several substances, moderate pressures, low gas consumption, solvent-free powders, suitable for high viscous or sticky products, fine powders with narrow size distribution, different morphologies, easy scale-up. Aerogels have proved as excellent carriers for bio and metal catalysts. Such catalysts shoved high outstanding activity and/or high selectivity for same high pressure/high temperatu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'An innovative system to impose altered features on a defined chromosome region and investigate its movement by fluorescence microscopy in the nucleus of a cell'.

assistant: **Innovation**

Our objective is to provide world-class research and training in the field of Life Sciences. Our innovative project applies interdisciplinary methods to identify new paradigms therefore contributing to the knowledge-based economy and society. Scientifically, the project involves cutting-edge microscopy in fission yeast to characterize the relationship between different chromatin features and their position in the nucleus. We will integrate distinct scientific approaches to obtain breakthroughs in the field. All research activities are in compliance with fundamental ethical principles. Further the project will be carried out in a laboratory where gender equality is encouraged, currently there are ten women in a group of fifteen. With respect to the training: we provide a comprehensive experimental work-plan which is designed to enhance the researchers career development and the diversification of his abilities at an advanced level. This is achieved by sharing reagents and expertise in collaborative exchanges as well as in meetings and workshops. We also present a timetable of the anticipated progress with milestones, promoting proactive project management. The diversity of valuable skills acquired will certainly benefit the researcher and support professional maturity in attaining an independent position. The candidate is a motivated and enthusiastic experienced researcher with an excellent academic and research track record. He developed his skills and scientific training on an international basis, convinced that mobility is central to the open-minded requirement of fundamental discoveries. He will join the well-known laboratory of Professor Robin Allshire in Edinburgh, who is recognized as world-leader in the field of chromosomal biology. Overall the project is a colla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Path2Power: an Ethnographic Study of Political Leadership Education' under Horizon Europe.

assistant: **Concept**

Political parties are crucial in representative democracies, allowing citizens to influence political agendas and decision-making. A key aspect of this role is the education provided by parties, from orienting new members to training future leaders. Given the growing challenges of distrust, polarisation, and anti-democratic leadership in liberal democracies, examining the educational dimensions of political parties is essential. Despite extensive research on societal participation and democracy, the intra-party educational paths of politicians remain largely unexplored.This project addresses this gap by investigating the intra-party education of young political leaders within the labour movement in Sweden. It focuses on a leadership school that collaborates with the Social Democratic Party, its youth wing and the Trade Union Confederation. This setting is particularly relevant due to the Social Democratic movement's strong ties to Nordic popular education and its history as a mass party with significant member influence.Drawing on theories of adult learning and identity formation, the study examines how young political activists are trained for leadership and how they perceive their own learning processes. The project moves beyond seeing political education merely as a means of acquiring political skills, instead focusing on individual development and the formation of collective identities within political movements. Using ethnographic fieldwork—including participant observation, interviews with participants and alumni, and textual analysis—it explores how young leaders experience the leadership school as a transformative process and how they negotiate multiple roles within the broader movement. By emphasising these political educational journeys, the project contribute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reliability of microfabricated actuators' (ROMA).

assistant: **Innovation**

MicroElectroMechanical Systems, or MEMS, represent an extraordinary technology that promises to transform whole industries and drive the next technological revolution. These devices can replace bulky actuators and sensors with micrometer scale equivalents that can be produced in large quantities by silicon micro-machining. This reduces cost, bulk, weight and power consumption while increasing performance, production volume, and functionality by orders of magnitude. MEMS improved functionalities and potential capabilities have brought in range many different application fields, including optical communications, medicine, guidance and navigation systems, RF devices, weapons systems, biological and chemical agent detection, and data storage. Because the field of commercial MEMS is still in its infancy, there is nevertheless an important issue for MEMS which still requires advanced research, i.e. MEMS reliability. Reliability is a particular challenge for MEMS because directly influences the acceptance, competitively and reputation of a technology.Many promising MEMS applications are to be found in safety critical systems and in harsh environments, where the cost of failure might be catastrophic. MEMS technology is evolving rapidly with the introduction of new processes, materials, and structural geometries. This brings many new failure mechanisms, which are poorly understood compared to the well- known failure mechanisms for common integrated circuits. The grand objective of this Project is to develop and apply reliability procedure for micro-actuators during their chip-production and their long-term characterisation by the development of measurement and data analysis procedures, the proposition of novel optical instrumentation in experimental measurement for re liability,