RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Training and research in Listeria monocytogenes Adaptation through Proteomic and Transcriptome deep Sequencing Analysis' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

List_MAPS is a network dedicated to the training of innovative young researchers in the field of Microbiology and Systems Biology. It focuses on Listeria monocytogenes, an ubiquitous pathogen that is in the EU the leading cause of mortality and food recalls due to foodborne pathogens, costing the EU millions of euro per annum in medical care and associated costs in the food sector. ESRs will develop scientific expertise through PhD training, mobility of researchers, summer schools, workshops and transfer-of-knowledge in the areas of Transcriptomics, Proteomics, Sequencing and Systems Biology. Working in this dynamic state-of-the-art field will provide for training of ESRs to the highest level, with co-operation and movement between academia and industry that will enhance ESR training. The overall objective of the research programme is to tackle food safety through the combination of high throughput Epigenetics, Deep sequencing of transcripts, Proteomics, Bioinformatics, Mathematics and Microbiology to decipher the transcriptional regulatory circuitry that drives adaptation and virulence of L. monocytogenes from farm to fork. This information will be exploited to understand how environmental conditions and food composition can influence GI tract adaptation/virulence and to develop an innovative transcriptome-based tool to assess in silico the virulence of large collections of isolates. This developed tool aims at replacing the currently used burdensome animal models. In addition to excellent scientific competences, competitive research requires a range of transferable skills to secure funding, optimise management of working teams and exploit research results. List_MAPS proposes an innovative approach to the training of ESRs in these transferable skills, combining socio-c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A novel approach for elimination of high affinity IL-2R expressing cells' (EHAIL2REC), addressing dissemination and exploitation.

assistant: **Impact**

The primary objective of this proposal is to physically eliminate malignant T and B cells that express Interleukin-2 receptor (IL2R) for treatment of certain leukemia/lymphomas and allogeneic organ transplant rejections. In recent years, therapeutic approa ches for hematological malignancies and allogeneic organ transplant rejections are moving away from non-specific cytotoxic to cell-specific treatment alternatives. The high-affinity IL-2R is primarily expressed in newly activated lymphocytes, including aut oimmune cells, abnormal T cells of patients with leukemia/lymphoma, and T cells of individuals rejecting allografts, but not in resting or memory lymphocytes. This aspect of IL-2R expression can be exploited to deliver proteins of interest, linked to IL-2, specifically into the cells. In this project, we propose to generate recombinant chimeric proteins consisting of IL-2 and cell death inducing proteins of human origin that will have the potential to treat these malignancies. These proteins will specifical ly induce cells’ own physiologic suicide mechanism by targeting the activation of the final executioner enzyme, caspase-3, of the system. The choice of biologics (chimeric proteins), the specificity, and the selected target of these biologics, ( activation of endogenous suicide mechanisms) to achieve cell death in IL-2R expressing cells make this proposal novel and significant. Therapeutic approaches using biologics, particularly of human origin, are conceivably much safer and effective than treat ments with nonbiological agents. If proved successful in vitro and in vivo in mice models of leukemia and/or transplantation, these novel regimens will have the potential to be applied to clinics in areas such as cancer, transplantation and autoimmunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechano-regulation of neural crest cell differentiation.' to be submitted under Horizon 2020.

assistant: **Abstract**

Neural crest cells (NCC) are a unique vertebrate-specific population of multipotent cells that contribute to the development and evolution of the vertebrate head. During embryonic development, cranial NCC give rise to a variety of hard and soft tissue cells including osteoblasts, chondrocytes, odontoblasts, glia and neuronal cells. Whilst we understand a great deal about how growth factors and soluble chemicals determine the generation, migration, proliferation, survival and differentiation of the neural crest, nothing is known about how mechano-regulatory factors influence NCC fate. Recent evidence has shown that mesenchymal stem cell fate and cell behaviours are controlled by mechano-regulatory signals via the actinomyosin skeleton, and the co-transcriptional effectors, Yap and Taz. Given that NCC are similarly exposed to different mechanoregulatory influences from stiff and soft matrices and tensions generated by the differential growth and morphogenesis of adjacent epithelial and mesenchymal structures, it is hypothesized that NCC differentiation is also mechano-regulated.  This proposal will use in vitro and in vivo approaches to test this hypothesis and determine if NCC fate is governed by mechano-regulatory signals, the differential regulation of the actinomyosin skeleton and Yap/Taz. The proposal will provide novel insight into the mechanisms of embryonic cell differentiation and craniofacial birth defects. Additionally, as neural crest stem cells have been identified in the adult, it will provide an understanding of how these may be manipulated to generate specific cell populations for tissue repair.The proposal will test a novel hypothesis and provide research training in a unique interdisciplinary skill set encompassing biology and engineering at the forefron
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Machine learning-based DAS data processing for geotechnical site characterisation of challenging soils' (GEOTECH-OPT-DAS).

assistant: **Concept**

The project will establish methodologies to exploit surface waves from Distributed Acoustic Sensing (DAS), making it possible to utilise and repurpose long fibre optic cables for geotechnical characterisation. DAS has been applied so far mostly inside boreholes, for VSP analysis and the surface waves components are not involved in the analysis. However, fibre-optics surface monitoring can provide loads of data to be inverted for 1D Vs-depth models. The combination of borehole DAS testing too, will provide essential information to be used in the building of the a-priori model, requirement for seismic surface waves inversion and hence will contribute to the reliable estimate of Vs variability over depth in questionable soils. Furthermore, in terms of field testing, spiked geophones and active shooting will also be done in parallel to the DAS surveys, to get robust seismograms of the subsurface and distinguish which type of source creates each soil’s response. Overall, the innovation of field and lab testing relies in the fact that data will be acquired through both cutting-edge technologies (such as fibre-optics) and traditional geophysical seismic prospecting methods to combine these and explore how they can be bridged to soil mechanics laboratory testing too. The vision is to bridge geophysics for soil's mechanical properties and lab testing for small strain shear modulus to identify elements of agreement around soil’s strength and hence be able to eliminate borehole drilling for sampling and instead rely on surface seismic testing that is more environment friendly and in line with European Union’s priorities. In terms of data analysis, this relies on the application of machine learning to train models and develop toolboxes for automatic data processing that can be used
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New discrete choice theory for understanding moral decision making behaviour'.

assistant: **Innovation**

Discrete choice theory provides a mathematically rigorous framework to analyse and predict choice behaviour. While many of the theory’s key developments originate from the domain of transportation (mobility, travel behaviour), it is now widely used throughout the social sciences. The theory has a blind spot for moral choice behaviour. It was designed to analyse situations where people make choices that are optimal given their consumer preferences, rather than situations where people attempt to make choices that are right, given their moral preferences. This neglect of the morality of choice is striking, in light of the fact that many of the most important choices people make, have a moral dimension.This research program extends discrete choice theory to the domain of moral decision making. It will produce a suite of new mathematical representations of choice behaviour (i.e., choice models), which are designed to capture the decision rules and decision weights that determine how individuals behave in moral choice situations. In these models, particular emphasis is given to heterogeneity in moral decision rules and to the role of social influences. Models will be estimated and validated using data obtained through a series of interviews, surveys and choice experiments. Empirical analyses will take place in the context of moral choice situations concerning i) co-operative road using and ii) unsafe driving practices. Estimation results will be used as input for agent based models, to identify how social interaction processes lead to the emergence, persistence or dissolution of moral (traffic) equilibria at larger spatio-temporal scales.Together, these proposed research efforts promise to generate a major breakthrough in discrete choice theory. In addition, the program will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Proposal to establish a system of industry metocean data for the offshore and research communities'.

assistant: **Innovation**

Strategic objectives addressed: To create an Internet central index and database of metocean data sets, collected by the oil and gas industry at various sites on the globe in the past and continuing at present. To facilitate harmonisation in quality and fo rmats, storing and retrieving of these industry metocean datasets for use by industry partners and scientific users. Proposal abstract:A very substantial volume of metocean in situ data is collected by or under contract to major oil and gas companies.This is done all over the world and over many years a large volume of data sets has been acquired, often at substantial cost and in remote areas. These are managed by the metocean departments of the oil and gas companies and stored in various formats and are on ly exchanged on a limited scale between companies. Despite various industry co-operative joint projects, there is not yet a common awareness of available data sets and no systematic indexing and archival of these data sets within the industry. Furthermore there is only limited reporting and access to these data sets and results of field studies for other parties, in particular the scientific community. Opening up these data sets for further use will provide favourable conditions for creating highly valuable extra knowledge of both local and regional ocean and marine systems. There are many projects and research groups within the EU Framework programme 'Sustainable development, global change and ecosystems' that would immediately make good use of the data and see wide applications for these data sets, if available and accessible.To stimulate and support a wider application of these industry metocean datasets it is proposed to establish a System of Industry Metocean data for the Offshore and Research Communitie s (SI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Wind energy sodar evaluation' (WISE), addressing dissemination and exploitation.

assistant: **Impact**

The general aim of the proposed project is the application of the SODAR technique (SODAR = sound detection and ranging) for reliable wind speed measurements in relation to the operating characteristics of large wind turbines.The main objectives of this project are:- To establish if and how a SODAR can be calibrated.- To establish the operational characteristics of SODAR.- To establish a general filtering technique for detection and treatment of unreliable data.- To test SODAR measurements in difficult circumstances such as offshore and complex terrain.- To carry out a power performance measurement with SODAR including a good uncertainty analysis.- To quantify the effects of vibrations in supporting structures and increased background noise on offshore SODAR measurements and evaluate long term (6 months ) offshore measurements.- To detect oncoming gusts with SODAR.- To simplify operation at remote sites.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Optical charge transfer processes in early stages of photosynthesis from first-principle computational techniques'.

assistant: **Innovation**

Optically exited charge-transfer states play a crucial role in the early stages of photosynthesis  but are notoriously difficult to describe efficiently with first-principles computational techniques. This difficulty not only limits the current understanding of the detailed atomistic processes in photosynthesis but is also an obstacle in simulating novel designs of photovoltaic materials that are based on organic absorbers. Current first-principles techniques for electronic excitations suffer either from failure to describe charge-transfer excitations or from poor scalability. This project aims to overcome the limitation in describing such optical excitations by implementing an efficient scheme to solve the Bethe-Salpeter equation, which is the state-of-art method for optical properties of solids and has been shown to correctly describe charge-transfer also in molecules. This method is based on a local-orbital basis for the electronic structure and uses a self-consistent Sternheimer equation to obtain the electronic response aiming to solve the Bethe-Salpeter equation for systems containing several hundreds of atoms and thus considerably broadens the range of what can currently be done with available software. It will be used to study the components of natural light-harvesting complexes that participate in the absorption and charge separation process. The application of this computational method is, however, not limited to these systems. On the contrary, this method, being a first-principles approach, has a wide range of applicability, including technological developments such as the design of photovoltaic devices. The implementation developed in this project will therefore be made available to several widely used electronic structure simulation packages through an inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Economics of innovation in construction' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Innovation in construction is a neglected but increasingly important topic. This project argues that competitiveness depends on the interaction between manufacturing, infrastructure services and the built environment. On the one hand, the rate of adoption of new technology in construction determines both the future competitiveness of this sector and the strength of the economy's productive structure. Consequently, this project will study the relation between the forms of industrial organisation and economic coordination in construction and their impact on its techno-economic performance. On the other hand, the 'peculiarities' of the construction sector impact upon its innovative activity. This may make it necessary to reconsider existing theories of innovation. This study will explore socioeconomic needs and technological opportunities for UK and, to a lesser extent, French construction, in the context of developments at the European level. Detailed analysis of UK construction will draw on the results of the Technology Foresight and case-study work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'STORAGE INNOVATIONS FOR GREEN ENERGY SYSTEMS' (SINNOGENES) targeting Horizon Europe.

assistant: **Abstract**

The European Commission’s Long-Term Strategy describes a number of pathways that reach between 80% and 100% decarbonisation levels. In every pathway a high level of direct and indirect electrification is envisaged, supported by a large-scale deployment of RES. The European power system has to address the residual load variability, on all timescales: from frequency response to inter-year flexibility. The main candidate solutions to provide flexibility are networks, demand-response, dispatchable and flexible power generation technologies, and energy storage. The appropriate deployment of innovative energy storage technologies is of primary importance for the clean energy transition. Sustainability and circular economy approach for storage innovations will minimize the environmental footprint and enhance the overarching efforts for achieving the European Green Deal targets.SINNOGENES project aims to develop the Storage INNOvations (SINNO) energy toolkit, a complete framework of methodologies, tools and technologies that will enable the grid integration of innovative storage solutions beyond the state-of-the art, while demonstrating sustainability, technical performance, lifetime, non-dependency on location geographical particularities and cost. It will develop successful energy storage business cases and systems and deploy them in innovative and 'green' energy systems at different scales and timeframes. SINNOGENES will target the effective integration of innovative energy storage systems and value chains at the interface of renewable energies and specific demand sectors, while ensuring the compatibility of systems and standards of distributed energy storage for participation in flexibility markets. Six pilot projects will take place in Portugal, Spain, Germany, Greece and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Prandtlplane ARchitecture for the Sustainable Improvement of Future AirpLanes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The project PARSIFAL (Prandtlplane ARchitecture for the Sustainable Improvement of Future AirpLanes) aims at defining the basis to improve the air transport of the future by evaluating the effects of the introduction of an innovative box-wing aircraft, called “PrandtlPlane” (PrP), into service. The project is focused on the medium size commercial aircraft category, in which the adoption of the PrP configuration can confer to aircraft with the same overall dimensions and fuel consumption of an A320/B737 the payload capacity of an A330/B767. In addition, a further objective of PARSIFAL is to develop the design tools that would allow to investigate the application of the PrP configuration to other aircraft categories, such as the ultra-large airliners, for which the PrP can provide a huge increase of payload (passengers and freight), keeping the dimensions fully compatible with existing airports. The efficiency of the PrP aircraft resulting after the conclusion of PARSIFAL will be compared with the most efficient equivalent conventional aircraft and the advantages of the new configuration will be quantified, taking also the standpoint of manufacturers, airlines and airport managers into account. The PARSIFAL Consortium is made of 6 partners from 4 different countries University of Pisa (Italy), as coordinator, University of Delft (The Netherlands), ONERA (France), DLR (Germany), ENSAM (France) and SkyBox Engineering S.r.l. (Italy). In addition, an Advisory Board composed of representatives of aircraft manufacturers, airlines and airport management companies will provide requirements, guidance and industrial expertise to shape and support PARSIFAL from different viewpoints.


**Keywords:** PrandtlPlane, Box-Wing, Novel Aircraft Configuration