RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reconstruction of Internal Doses from Long-Lived Radionuclides foll owing a Large-Scale Radiation Accident.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Foreseen ResultsBased on existing internationally agreed computer codes for the calculation of dose coefficients computational tools for the inverse problem of retrospective internal dose assessment in the case of large-scale accidents will be developed.These tools will be validated and applied to a retrospective evaluation of strontium-90 and actinide doses with a large amount of measurement data from the regions of Chernobyl and Kishtym.The aim of this project is to develop and implement models and methods for retrospective assessment of internal doses by Sr-90 and long-lived isotopes of the actinide elements plutonium and americium following large-scale radiation accidents. These models and methods will be validated and applied to the Chernobyl and Kishtym situations.Methods and computer codes for dose reconstruction based on a variety of sources of primary information will be developed.Additionally, the biological effects of hot particles of Chernobyl origin will be compared to that from uniform irradiation by in vitro experiments. Together with some theoretical considerations the biological effects of hot particles in the respiratory tract will be modeled with consideration of oncogenic processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plant Cell Wall Dynamics During Cell Cycle' (CeWalDyn) under Seventh Framework.

assistant: **Objectives**

Unlike in animals, the formation and growth of the plant body is strongly influenced by the presence of a rigid structure encapsulating the cell – the cell wall. Plant development must therefore be coordinated with the synthesis and remodelling of highly complex cell wall structure. Cell elongation and cell division are the two main processes which give rise to the plant body. Whilst cell wall properties during cell elongation have been relatively well studied on Arabidopsis hypocotyls and on Chara internodes, description of cell wall behaviour associated with cell division is largely absent. DNA microarray data on synchronous cell cultures suggest up-regulation of many cell wall component acting enzymes in particular points of the cell cycle. Moreover, the concept of plant cytokinesis supposes structural changes in cell walls.We propose to use the state of art technologies in cell, developmental biology and systems biochemistry to describe cell wall related processes in dividing cells. As model systems we will use Arabidopsis plants and cell cultures but also a broad panel of algae, land plants and crop species. Our work will incorporate detailed quantitative and qualitative analyses of the dynamism of the cell wall components and related enzymatic activities at different stages of the cell cycle. We will also employ state of art microscopic and ultramicroscopic techniques to study the spatiotemporal distribution of the cell wall components. This approach will include development of novel technology for in situ and real time detection of various carbohydrates. We will also analyse cellular and developmental consequence of the loss- and gain-of action of the cell cycle regulated cell wall-acting enzymes to get the functional information of molecular pathways leading to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Plasma Processes in the near-Earth Space: INTERBALL and beyond' (1998-2002).

assistant: **Concept**

The focus of INTERBALL'2002 is on recent advances in Solar-magnetosphere-ionosphere interactions and space weather research and on the promotion of new results based on recent satellite and ground-based multipoint observations, improved instrumentation, theoretical models and development of new numerical methods for simulations. INTERBALL'2002 will be held under the auspices of Academician Professor Ivan Juchnovski, the President of the Bulgarian Academy of Sciences (BAS). The conference will be organised by the Finnish Meteorological Institute (FMI) acting as a coordinator and the Solar Terrestrial Influences Laboratory at BAS (STIL - BS) will be responsible for the local organisation. The FMI is a leading Finnish research centre, with a rich experience in participation in EC and other international projects. STIL-BAS has wide experience in organising international conferences and large scientific meetings. The chair of the Local Organising Committee (LOC) Professor D. Mishev is a co-chair of the Program Committee (PC). The PC is constructed from representatives of all countries. Involved in the INTERBALL space project and of other world acknowledged scientists in the field of Sun-Earth interactions.Co-chair of PC is Professor L. Zelenyi, Russia, a scientific coordinator of the INTERBALL project. Balkan and eastern Europe related members are E. Sarris. K Kudela, J. Blecki. Z. Nemecek. EC related members are the proposer T. Pulkinen, I. Sandahl, A. Roux, J. Sauvaud, J. Buchner, M. Roth, H. Alleyne. US and Asia related members are A. Nishida, D. Sibeck, A. Lui. Russia and Ukraine are presented by Yu. Galperin and V. Ivchenko. The PC members will be involved in reviewing the paper submissions and in summarising the results of the presented posters. The conference organise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Learning from International Networks about Errors and Understanding Safety in Primary Care'.

assistant: **Innovation**

There is a deficit in activity related to patient safety in primary care and the primary care/secondary care interface in Europe. This deficit relates to research, to sharing of information, to learning and to collaboration.This co-ordination action will specifically address issues addressed in the call through: (1)The development of a taxonomy of adverse events and errors. (2) Identifying best clinical practice and the way that it improves patient safety through an understanding of decision making and medication errors in primary care. (3) Achieve consensus on the measurement of safety culture and leadership in the primary care context and develop agreement on indicators which can be used to assess patient safety and improvements in safety culture. (4) Enhancing existing knowledge from quality improvement techniques which are widely used in the primary care setting and applying these to learning cycles for improvements in patient safety. (5) Develop a reporting system which can be used for identifying errors in primary care in countries where activities related to patient safety in primary care are in a nascent state and develop an accreditation framework for patient safety in these nascent organisations. (6) Identifying methods to involve patients in patient safety initiatives in primary care. (7) Identifying communication-related threats at the primary-secondary care interface and developing intervention strategies to overcome these.Building up an existing network of researchers into a pan European network, this co-ordination action will extend the current knowledge and experience from countries where the importance of patient safety is nationally recognised to countries where it is less developed, ensure that there is an appropriate focus on primary care and encoura
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of inspection systems for hte inspection of metal pipelines buried underground, in concrete in water or covered with coatings (PIPESCAN)' (PIPESCAN).

assistant: **Innovation**

Over 10m kIn of pipelines in Europe carry hazardous fluids including oil, oil products, chemicals and gases; they are subjected to corrosion by the environmentand contents and, in some cases, mechanical fatigue. Failure to inspect them can result in leakage of hazardous material into the environment and even explosion. Up to 90% of these pipelines are inaccessible for inspection by current inspection methods because these are: (1) Buried under concrete. (2) Buried underground. (3) Underwater or (4) Covered with coatings. Due to undetected leakages, in Europe up to 4m gallons of oil are leaked into the environment per year. The consortium SMEs propose to develop a set of mechanised inspection techniques, sensors and systems for finding defects and corrosion in pipe, which is inaccessible to the operator (ie pipes buried underground, in concrete in water or covered with coatings such as thick paint or insulation) without the need to ""dig up"" or remove coatings. By developing this technology; the consortium SMEs will access the 250 million Euro per annum, pipeline and pipework inspection budget of World Oil & gas, chemical and electricity plant operator companies, 4 years after project completion. The economic objectives are: (1) A significant reduction in the cost of inspection. Europe wide saving of 200 million Euros is expected 4 years after project completion. (2) A reduction in the number of spillages and subsequent product losses and clean-up costs. (3) Profits from sales of the inspection systems and inspection service (approx 7m Euro bver 4 years). The social objectives are: (1) Elimination of hazard due to possible exposure of workers to asbestos used for older pipe insulation. (2) Elimination of hazard due to working on hot surfaces. (3) Elimination of labour i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bioinspired living skin for architecture', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Biofilms, an assemblage of surface-associated microbial cells that is enclosed in an extracellular polymeric substance matrix, are recognised as one of the most stable biological systems on earth. The beneficial use of biofilms for protection is nearly unexplored since up-to-date research is focused on the prevention of its formation. In the ARCHI-SKIN project, we will explore the design principles underlying fungal biofilm to bridge the knowledge gap on the chemistry-structure-properties of the biological systems’ interface. Mechanisms of biofilm formation, its structure, function, quorum sensing, and performance will be understood at multiple scales following the best practices of materiomics. It will be achieved by advancing state-of-the-art in-situ laboratory routines and use the latest mathware solutions in combination with the design-build-test-learn approach for the experimental work. In the following step, we will develop a bioactive protective coating system working in conjunction with nature. We will benefit from the synergic strength of living fungal cells, bio-based ingredients, and bioinspired concepts for materials protection. Advanced in-silico methods will be used for the integration of active ingredients and modelling of optimal and long-lasting nutrient sources compatible with the enzymatic profile of selected fungal strains. We will design and create technically applicable, controlled, and optimized biofilm built by the yeast-like ubiquitous and widespread oligotroph fungus, Aureobasidium pullulans, that will effectively protect the surfaces of biomaterials, concrete, plastics, and metals, among others, assuring optimal service life performance and remarkable functionalities including self-healing and bioremediation. Our pioneering approach for materi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Deep imaging with time-reversed light' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Microscopy enabled the birth of modern neuroscience, by allowing Ramón y Cajal to formulate the neuron doctrine. Since then, remarkable advances in optical resolution, speed and probe development allowed scientists to study the function of neuronal circuits with ever increasing detail – with one critical limitation: No conventional microscope can focus light deeper into intact tissue than a fraction of a mm. This leaves 90% of the intact rodent brain and over 99% of the intact primate brain inaccessible. As a result, the deepest layers of the neocortex and nearly all subcortical structures are currently outside the reach of non-invasive microscopy, representing a fundamental barrier towards further progress in understanding the brain.Existing fluorescence microscopy techniques, such as confocal and two-photon microscopy, attempt to image deeper by rejecting scattered light or by selecting non-scattered (ballistic) photons for focusing. However, beyond depths of several hundred µm this approach becomes futile because hardly any ballistic photons remain.We recently achieved two breakthroughs by turning this strategy upside down and focusing with scattered photons: First, we developed a new approach for fluorescence microscopy that uses a process called optical time reversal, with which we achieved an unprecedented imaging depth of 2.5 mm in ex vivo tissue. Second, we discovered a correlational structure of scattered light, which can be exploited for deep tissue imaging.Still, fundamental challenges remain for in vivo imaging. The goal of this proposal is to break the depth barrier of microscopy and investigate previously unreachable areas of the live brain, by harnessing optical time reversal and scattering correlations. We will demonstrate the power of this approach in l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimisation of industrial kilns by means of using low oxygen content flues-gases from industrial gas turbine cogeneration systems' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

This proposal addresses a new approach of integrating the benefits of Cogenerat ion of Heat and Power -CHP- in ceramics and other related industries where high temperature heat is needed for the operation of the kilns and the furnaces. The risk is well considered and is justified by the significant reduction of e nergy consumption and the corresponding positive environmental impact in this e nergy demanding industrial sector the optimization of the process control and t he product quality, the minimization of the pollutants emissions and finally by the ability to apply cogeneration of heat and power in small and medium size i ndustry which forms a potentially significant market. Side benefits include the reduction of the cost of the products and some positive impact on the kiln and furnace design. The goal is to develop a process which will overcome the pr oblems related to the re-use of the iowO2 content exhaust-gases generated from industrial gas turbine CHP sets -Turbine Exhaust Gases, TEG,- as an oxidiser fo r the firing of the material inside the kilns used in ceramics and related indu stries. These problems are associated with the reliable operation of the small multiple afterburners needed in these applications to accurately control the te mperature fields inside the kiln, occurring when using a variety of mixtures of flue-gases, preheated air and fuel to achieve the different temperature levels needed by the firing process and to reduce the pollutants emissions. In connec tion with the reliable operation of the burners the effects on and the optimiza tion of the temperature field inside the kiln is of great concern for better pr oduct quality. The construction and operation in the laboratory and on field of an experimental rig fed with exhaust-gases of the same
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A molecular basis of kinetoplastids SL trans-splicing' under Horizon Europe.

assistant: **Concept**

Kinetoplastids are unicellular eukaryotic parasites responsible for severe human pathologies, such as sleeping sickness, Chagas disease and leishmaniasis. Kinetoplastids have diverged early during evolution and harbor many intriguing cellular and molecular peculiarities. Among these is their remarkably streamlined nuclear genome characterized by a high gene density and significantly divergent and specialized gene expression systems. A main example of such divergence is the polycistronic transcription of all their genes producing long messenger RNA precursors (pre-mRNAs) containing tens to hundreds of coding sequences. These pre-mRNAs are dissected into monocistronic mRNAs by SL trans-splicing, a process during which a spliced leader (SL) RNA is intermolecularly fused to the 5’end of all mRNAs by the trans-spliceosome. Although this machinery is essential for gene expression, the lack of structural information and the high divergence of its RNA and protein elements have hindered a mechanistic understanding of how kinetoplastids employ SL trans-splicing to generate their entire mRNA transcriptome. Here, we will use innovative approaches to provide the structural and mechanistic basis of SL trans-splicing in kinetoplastids by using cutting-edge structural biology techniques and state-of-the-art genetic and in silico tools. By combining genome editing, purification of endogenous trans-splicing machineries, high-resolution cryo-electron microscopy, AI-based interactome approaches, and novel in vivo assays, we will reveal the mechanism of SL snRNP biogenesis, the molecular basis for SL snRNP intermolecular recognition and activation by the trans-spliceosome, and the central mechanism of trans-splicing orchestrated by the highly divergent kinetoplastids trans-spliceosome. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Anaerobic methane oxidation in granular sludge reactors for sustainable wastewater treatment'.

assistant: **Innovation**

Besides the quality of the treated wastewater, secondary objectives dealing with the sustainability of wastewater treatment are gaining importance. This has resulted in several important innovations over the last 20 years, such as granular sludge reactor technologies and innovative nitrogen removal techniques based on anaerobic ammonium oxidation (anammox). In granular sludge reactors, biomass is grown in the form of dense, fast-settling granules, resulting in compact wastewater treatment systems which allow a high loading rate. The anammox conversion comprises the conversion of ammonium and nitrite to nitrogen gas by autotrophic, slow growing micro-organisms. Nitrogen removal techniques based on this conversion result in substantial savings in aeration costs and external carbon source addition costs compared to conventional nitrification-denitrification over nitrate, at the same time minimizing CO2 emission and sludge production. Recently, anaerobic methane oxidizing bacteria (anMOB) have been discovered and first attempts have shown that a combination of anMOB anammox bacteria for a simultaneous nitrogen and methane removal from wastewater is possible. For future process scale-up, research on process engineering is the next key issue. The goal of the proposed research project concerns the optimization in terms of design and control of a granular sludge reactor for simultaneous anaerobic methane and nitrogen removal, to combine the advantages of anammox-based granular sludge reactors with the removal of methane, a strong greenhouse gas.  The project involves two stages, in which the application of anaerobic methane oxidizing bacteria is subsequently studied under anoxic and aerobic reactor conditions. The project goal will be achieved combining mathematical modelling a