RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'TOWARDS NOVEL NANO-SCALE TECHNOLOGIES BASED ON PHORETIC FLOW EFFECTS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Most devices that transport bulk fluids make use of pressure gradients (`pumps’) or external forces (e.g. gravity powers hydro-electric turbines).  Increasingly, modern technology is addressing problems where fluid transport takes place in sub-micron sized channels, or in pores. The physical laws of transport in such channels are qualitatively different from those that determine bulk flow; they are poorly understood and, importantly, barely exploited.  The aim of the proposed research is to lay the basis for an entire novel technology where thermal gradients and concentration gradients along nano-sized channels are harnessed to drive devices that have no equivalent on the macroscopic scale.  Such gradient-driven surface flows  offer a huge scope for fundamental advances with very significant technological implications. We envisage breakthroughs in the area of energy extraction from salinity gradients (`blue energy’), ultra-filtration and desalination, and the development of novel, highly sensitive protein-separation devices. This new approach will surpass the intrinsic limitations of current technologies. The expected huge improvement in efficiency will be a game changer and will break the current barriers in the development of technologies such as e.g osmotic energy harvesting.All the  applications  share the same underlying science and can therefore be addressed by the proposal team.  We will engage with industrial partners inside the team and with new partners that we will approach through our Knowledge Transfer Facilitator, to translate basic science into proofs-of-principle, pilot plants and, subsequently, full scale applications. The potential economic impact of phoretic technologies is difficult to over-estimate: the research is truly high-risk, high-yield.  By t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modelling, prediction and prevention of the impact of mine effluent s on river water quality using artificial neural networks' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives and content River water plays an essential role in the hydrological cycle. Quality of river water will affect the quality of receiving water bodies (other rivers, streams, lakes, ocean, and aquifers) and will make a direct impact on the greater surrounding environment. The nature of mineral extraction operations and subsequent waste disposal and discharge activities create a potential pollution hazard for water resources around such activities. Due to the significance that it takes in the global ecosystem and complex, multiple interrelationships of hydrological, hydrochemical and hydrobiological determinants involved, the control of river water quality necessitates dedicated environmental management systems. These systems should embrace the implementation of continuous monitoring, creation of databases for the management of spatially and temporally distributed water quality data and the development of simulation and predictive systems using the measured information, for the early detection and assessment of possible risks/hazards so that protection measures could be implemented. In general environmental attributes are characterised by very high variability. Consequently, the relation between variables involved exhibits a high degree of nonlinearity and in order to model them effectively, appropriate non-linear modelling methods become a prerequisite. At present, there are various methods for analysing and modelling environmental variables and predicting impacts. However, notwithstanding the advances and achievements of most models, they all rely on very strict assumptions. Most of these techniques tend to simplify the problem by ignoring its spatial or temporal dimensions. Additional difficulties with spatio-temporal phenomena occur as a result of incomplete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PlantHUB - Boosting technology transfer and responsible research and innovation (RRI) in plant sciences' in the context of a Horizon 2020 call.

assistant: **Objectives**

In PlantHUB will capture the academic, industrial and regulatory expertise from 5 world-class universities, 1 governmental organization, 7 enterprises including 4 SMEs to train 10 ESRs in skills and competencies necessary to apply responsible research and innovation (RRI) in the area of plant breeding and production. We wish to address the demand of RRI leadership in plant science related research and diffusion of innovation. The individual research projects are demand-driven, responding to the needs of companies - particular SMEs - to increase R&I capacities. The outcomes are new molecular tools for plant breeding, new forage, cereal and oil crop varieties, non-invasive imaging and phenotyping technologies, intelligent lighting systems for plant growth, new software and services for complex genomic analyses, and plant product quality.  PlantHUB industrial doctoral programme is ground-breaking in a number of respects: (i) doctoral training is placed into an entrepreneurial environment of leading public and private organisations (ii) it combines practical hands-on R&D and technology transfer in plant breeding and production with RRI training and practise. On completion of the training, graduates will have deep interdisciplinary knowledge of plant breeding, crop improvement, high-throughput technologies, isotope and big data analysis. In combination with a portfolio of transferable skills they will be able to take a lead in stakeholder & public engagement, innovation management, technology transfer and entrepreneurship. Our programme will become a flagship example at the forefront of intersectoral research, underpinned with a carefully created training curriculum to foster awareness, know-how, expertise and competence in RRI.


**Keywords:** plant breeding, plant producti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative Applications of Extracorporeal Photopheresis in Solid Organ Transplantation' to be submitted under Horizon Europe.

assistant: **Abstract**

Organ transplantation remains the only definitive treatment for end-stage heart, lung, liver or kidney disease. Early transplant outcomes are now generally excellent, dramatically reducing patients’ mortality and morbidity. Nevertheless, transplantation still faces significant obstacles, especially long-term immunosuppression-related toxicity and chronic decline of transplant function, which are the leading causes of transplant failure. To break these barriers, which represent a very significant societal and economic burden in the EU, there is a need for innovative therapies to lessen our reliance on conventional immunosuppression and better control non-resolving inflammation. Extracorporeal photopheresis (ECP) is now being investigated as a personalized, adjunct immunosuppressive therapy in some organ transplant settings. However, ECP is regarded as a controversial therapy, primarily because current understanding of its pharmacological actions is incomplete, but also because there remain questions about optimal manufacturing processes, quality-control and personalized clinical indications. The exTra project asks whether a better mechanistic understanding of ECP can guide us more efficiently towards novel applications. Specifically, exTra brings together European experts in clinical transplantation, immunology, pharmaceutical development, computational biology and medical device manufacture to address key questions through a coordinated, interdisciplinary effort. exTra proposes 10 independent doctoral research projects with the ambition of providing its trainees with a comprehensive understanding of basic and translational immunology, especially relating development and licensing of new immunotherapies. Through its research and training activities, the exTra project wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Oil and Gas Exploration Made Greener and Cheaper'.

assistant: **Innovation**

The exploration phase in the oil and gas (O&G) industry is extremely expensive and yet surprisingly inefficient. Even the most advanced exploration techniques can at most detect the probable presence of hydrocarbons, but not quantify it. O&G companies spend hundreds of million of euros to drill wells that turn out not to have a real commercial value while the ecosystem in O&G field is permanently damaged by the intrusive methods in use nowadays. Due to environmental concerns, the policy makers and the citizens call for 'greener' solutions, to the best possible extent. We offer an innovation that avoids unnecessary exploration drilling: our patented and tested technology predicts with high accuracy whether an O&G field will be productive by only analysing the DNA of one sample of soil of 1 mm3 at about 50 cm below the surface.The 'trick' is to correlate the microbes in the shallow soil with the presence of hydrocarbons in the deeper subsurface by means of machine learning techniques. We have proved in numerous field experiments that our method is up to three times more accurate and 100 times cheaper to perform than the mainstream ones. We have already a few paying customers but we want to reach a global commercial success. This Phase 2 project has one main goal: open up the markets the European North Sea (for offshore) and of USA and Argentina (for shale), which we have been identified as the most interesting markets for us in the short and medium term. Our project will benefit the EU in many respects: Biodentify is a Dutch company, and as a result of the activities of this project we will reach a cumulated turnover of about €50M by the end of 2022 and increase our staff to 39 FTEs in the same period. Additionally, offshore O&G in the North Sea is by far the largest sour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Oil mill waste waters concentration and drying via an innovative barometric vacuum distillation system' in the context of a Fifth Framework call.

assistant: **Objectives**

This project concerns the environmental pollution of oil waste waters (OMWW) and aims at eliminating it by means of an innovative energy-efficient and cost competitive, distillation technology with a broad application potential in European Mediterranean Areas and beyond. The approach is based on concentration of OMWW through an innovative distillation: process driven by a refrigerator-heat-pump-loop and occurring under barometric vacuum conditions. The barometric vacuum distillation plant (BVDP) proposed has several useful features: great energy-efficiency; durable and economic industrial components with low maintenance requirements, use of either conventional or renewable energy sources (e.g. FV or wind energy) for driving its refrigerator-heat-pump loop. The overall aim of the project is the design, construction and test of a small capacity prototype BVDP for carrying out a technical validation of the proposed technology for the control of OMWW environmental effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'In-Operando characterizatioN of anti-ambipolar mIxed Conductors' under Horizon Europe.

assistant: **Concept**

This proposal concerns the fundamental properties of mixed ion-electron conducting polymers. These materials are biocompatible and conduct both ions and electrons, making them excellent candidates for bioelectronic applications interfacing with living tissue. The conductivity of these materials increases under bias by injecting ions and concerted doping of the semiconducting polymer. However, upon high doping the conductivity can no longer increase but rather decrease. The exhibited maximum, where any voltage change lowers the conductivity, amounts to an anti-ambipolar response which finds applications in biorealistic artificial neurons. The underlying mechanisms, however, remain unknown in part because of the inherent instability of highly doped polymer semiconductors. Without understanding the fundamentals of these materials, targeted optimization and development are inhibited. Additional complications arise from the complex environment in which they operate, consisting of ions and water. Their characteristics and response to doping are highly different in these conditions compared to ex-situ measurements, making in-operando characterization absolutely crucial. In-operando characterization is however not straightforward and requires specialized equipment.In this IONIC proposal, a research plan is described to investigate the fundamentals underlying anti-ambipolarity by designing and building novel in-operando measurement tools, and applying them to a uniquely stable ladder-type polymer. This unprecedented approach allows for characterizing, for the first time, the doping interactions throughout the anti-ambipolar regime.Project IONIC marks a major breakthrough in understanding organic semiconductor doping in electrolytes. The resulting general structure-property relat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Consolidating plans for the Atacama Large Aperture Submillimeter Telescope'.

assistant: **Innovation**

The landscape of future ground-based European astronomical research infrastructures expected to start in the 2030s is broad and diverse, ranging from low-frequency radio (SKAO), to the optical (ELT, EST), all the way to cosmic rays (CTAO) and gravitational waves (Einstein Telescope). There are two glaring omissions, however. The first is a sensitive, high resolution next-generation facility operating at (sub-)millimeter wavelengths (0.35-10 mm), a crucial observing window for the study of a broad range of astrophysical objects, from our Solar System to the Milky Way, nearby galaxies, and the distant universe. The second is that currently planned facilities are not truly prepared to operate in a low carbon emissions future, meeting the needs of the research community and the aspirations of the EU for carbon-neutrality. This project, consolidating the plans for the 50-meter Atacama Large Aperture Submillimeter Telescope (AtLAST), directly addresses both needs, providing solutions that will inform other observatories along the way, especially our partners ESFRI landmark (ESO-ELT) and project (EST). Our ambition is to harness European knowhow and cooperate on a global scale to revolutionise our understanding of the (sub-)mm universe, while pushing observational astronomy towards a greener future. Strengthened by a H2020-funded design study and an engaged community of about 200 researchers worldwide, we have produced science cases, telescope conceptual designs, and plans for a sustainable, off-grid power system. We are now ready to consolidate the AtLAST concept, prototype and test our technology solutions, perform a full lifecycle assessment of the facility, and to expand our user community. By the end of this project, AtLAST will have increased the technology readiness lev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on '3D printing fabrication of tailored interfaces for pressurized Protonic Ceramic Electrolysis Cells'.

assistant: **Innovation**

Pressuriz3D aims to advance in the field of pressurized protonic ceramic electrolysis cells (PCEC) with the utilization of advanced fabrication techniques such as masked-stereolithography (MSLA) and robocasting. Aiming to reduce the utilization of fossil fuels on a global scale, the design of systems for hydrogen production via steam electrolysis is fundamental to increase the reliability of renewable energy sources.  PCECs are high-temperature electrolysers which use ceramic electrolytes characterized by high protonic conductivity. Compared with other HTEs (e.g., solid oxide electrolysis cells, SOEC), this type of conduction mechanism can significantly reduce the operating temperature of the device (e.g., from 700-900 °C to 300-650 °C respectively for SOEC and PCEC). Additionally, PCECs can produce directly pure hydrogen eliminating the purification process to remove steam necessary for SOECs.Fabrication of a PCEC via additive manufacturing (AM) techniques can significantly reduce production costs and the waste of material during processing, thus boosting sustainability and circularity aspects. complex-shaped electrolyte can be produced increasing the mechanical resistance with the joining materials to maintain the gas tightness of the system (i.e., glass-ceramic sealants). Patterned surfaces coupled with glass ceramic sealants will allow the utilization of pressurized gases, which are expected to significantly increase PCEC performances. Furthermore, geometry modification of the electrolyte membranes, thanks to the fabrication via MSLA printing, can further improve the performance and the hydrogen production rate. A high impact on the future career of the candidate is expected by complementing his current background with new skills in the field of hydrogen conversion,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'What doesn’t kill you: primed and adaptive mechanisms of treatment resistance in ovarian cancer'.

assistant: **Objectives**

Cancer therapy resistance is a complex, dynamic process. Pre-existing heterogeneity in cell states provides substance for evolutionary selection, and their plasticity enables adaptation during the therapy. Recently, we discovered a stress-related, immunocompromised cell state underpinning both intrinsic and adaptive resistance in high-grade serous ovarian cancer (HGSC) metastatic tumours, suggesting that pre-existing stress improves the resilience of cancer cells during neoadjuvant chemotherapy.To unveil how past stress responses prime cancer cells adaptation during therapies, I suggest a novel approach that combines dynamic stress recording with the identification of pre-existing resistant states via my novel methodology, ReSisTrace. We will apply this ground-breaking approach in patient-derived organoids to reveal how past stress signalling of a single cell is reflected in its adaptive stress responses and survival upon chemotherapy or cytotoxic immune attack. We will further characterise subclonal and spatial enrichment of the identified resistant phenotypes in longitudinal clinical specimens to incorporate the effect of tumour microenvironment in discovered mechanisms.Importantly, simultaneous characterisation of primed and adaptive resistance enables us to overcome both of them by a sequential combination of drugs where the first will drive cells to identified sensitive states prior the treatment, and the second will block identified adaptive responses during the treatment. After finding the most effective pre-sensitisers and anti-adaptive drugs in the organoids, we will validate most promising combinations in patient-derived xenograft models to pave the way for clinical translation. By targeting both pre-existing cell states and their plasticity, my novel approach