RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of cellular mechanical stress in the pathogenesis of neurodegenerative disorders' in the context of a Horizon Europe call.

assistant: **Objectives**

NEUROMECH aims to establish a new generation of skilled, entrepreneurial, and innovative scientific leaders that will integrate the currently isolated fields of mechanobiology and neurodegenerative diseases.Mechanobiology explores the effects of physical forces on cell physiology. Evidence indicates that key mechanisms of neurodegeneration – cytoskeletal alterations, protein aggregation, protein phase transitions, DNA damage accumulation, and metabolic alterations – can be a consequence and cause of mechanical alterations. Mechanobiology may therefore be a unifying process in a broad spectrum of neurodegenerative diseases, which have rarely been approached from the mechanobiology prospective. NEUROMECH will bridge this gap and address the need for disease modifying therapies focusing on Alzheimer's and Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis.NEUROMECH is an international and synergistic network of key scientific experts in mechanobiology and neurodegenerative diseases. Its ambitious research program ranges from atomic force microscopy to in vivo investigations using magnetic resonance imaging. The consortium includes industrial partners and a top European business school to provide training on managerial and strategic skills. These tools will allow Doctoral Candidates to fully understand and navigate both the complex landscape of neurodegenerative diseases research and the value chain of the very different organizations operating in this domain.Overall, NEUROMECH will provide Doctoral Candidates with multidisciplinary, intersectoral training that will enhance their career perspectives in academic and non-academic sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Arabidopsis genome project'.

assistant: **Innovation**

Arabidopsis has been adopted as a model organism for the molecular analysis of complex plant processes, and consequently there has been a very large increase in the number of genes isolated by map-based cloning methods. Accompanying this work, physical maps of the 5 chromosomes are being established which will increase the ease and effectiveness of gene isolation. In addition, techniques for insertional mutagenesis, using transposons and T-DNA, have been developed and are being applied on a scale commensurate with obtaining multiple insertions in every gene. The next step in developing the full utility of Arabidopsis is the systematic sequencing of the genome, which is a foundation for significant advances for increasing the scope of many aspects of plant research, for making it more cost-effective, and for making the quality and likelihood of success of research programmes more assessable. The goal of sequencing the entire genome of selected model organisms is the first step in defining the structure of all transcripts, the expression patterns of all genes and the phenotypes of mutations in all genes. The conceptual framework and tools for this are now available in Arabidopsis. Therefore a strategy of genome sequencing which accumulates sequence at known positions in the genome, thus permitting an orderly strategy for completion and providing an immediate resource for systematic function search, has a high priority in plant science research. This proposal aims to extend the pilot-scale genome sequencing project launched by the EC in 1993 to complete the sequence of chromosome 4. This is the first plant chromosome to be physically mapped, and several discoveries relevant to sequencing strategies were made in this work. The first is the assembly of 4 YAC contigs covering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'NANOSTRUCTURED LARGE AREA PLASMONIC SYSTEMS DEPOSITED BY GAS FLOW SPUTTERING AND PLASMA-ENHANCED CVD PROCESSES'.

assistant: **Concept**

Nanocomposites made of metallic nanoparticles (e.g. Au, Ag, Cu) embedded in a transparent matrix may display unique optical properties due to plasmonic effects resulting from the interaction of light with particles of nanometric size. This original behavior can be exploited in a wide range of applications including chemical and bio-sensors with extremely high sensitivity, spectroscopy, solar energy harvesting, and nanophotonics.In this context, Nano-LAPS project aims at the deposition of high purity nanocomposite materials with well controlled plasmonic absorption peak in the visible or infra-red ranges. Objectives are based on the encouraging results of preliminary work realized on this subject at FhG, which establishes a solid starting point for this project. The chosen approach is based on a unique and original deposition method combining gas flow sputtering and Plasma-Enhanced CVD processes. This technology allows coating large area substrates, with the highest purity, for a wide choice of nanoparticles (Au, Ag, Cu, Al, W, and high performance conductive oxides) and matrices (SiOxCy, TiOxCy, plasma polymers).The host organization senior researchers and management have an established reputation in research on thin films and nanotechnology, and are highly qualified to lead and to support this project, providing the best conditions for its success. Besides, the researcher has proved his capacity in leading and structuring scientific works on thin films coatings and processdesign. His experience will complement that of the host organization with new and original topics likely to draw scientific attention and open up perspectives for this research work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Genomics of sexual isolation and reinforcement in the house mouse'.

assistant: **Concept**

One main topic in evolutionary biology is this unresolved and fascinating riddle: how do new species arise? In the last two decades, attention focused on the possibility that selection could play a major role in speciation, particularly when reproductive isolation is impeded by ongoing gene flow. Nowadays, the plausibility of adaptive speciation is accepted but the debate is shifting towards the challenges of identifying the factors favouring this process and of assessing the genetic basis of adaptive divergence. This project proposes to address the mechanisms of adaptive speciation in the house mouse, a model species for the study of speciation, by developing a genomics and candidate gene approach which will complement the behavioural and proteomics studies in progress on this biological system. Specifically, the project aims to elucidate the genetic basis of sexual isolation and reinforcement between two European subspecies of the house mouse (Mus musculus domesticus and M. m. musculus) which hybridise in nature but show some degree of prezygotic isolation in their contact zone. Sexual isolation between these two taxa originates from the divergence of the olfactory mate recognition system. Therefore, I propose that loci implicated in pheromone recognition are prime candidates for speciation in the house mouse and I will test this hypothesis by seeking for a signature of divergence under selection in genomic regions containing these candidate genes (Murine Urinary Protein and Vomeronasal Receptor gene families). My approach will be to exploit publicly available genomic resources for the house mouse and recent progress made in the characterisation of chemosensory related gene and the idea will be to combine high throughput technologies and population genetics tools in o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Differential regulation of gonadotropins'.

assistant: **Objectives**

As wild fish stocks are dwindling, aquaculture is increasingly relied upon to supply the growing world demand for fish. However aquaculture operations are largely impeded by our limited understanding of the mechanisms that control reproduction in farmed fish. The gonadotropins LH, FSH and their main stimulator GnRH are key regulators of the reproductive axis in vertebrates. We propose to utilize the unique anatomical traits and rich toolbox of the zebrafish model to dissect the mechanisms driving the differential regulation of LH and FSH. We will adopt a transgenic approach combined with state-of-the-art live imaging techniques to investigate the intricate interplay between GnRH and gonadotropes in the teleost pituitary. Taking advantage of the unique anatomy of the zebrafish, in which LH and FSH are discreet cell types, and the unique expertise of Mollard’s lab in cellular in vivo imaging of the hypothalamus-pituitary tract, we will investigate the functional role of both the circulation and direct contacts (GnRH terminals which directly abut onto gonadotropes) in delivering GnRH signals to target cells and reveal how these signals are interpreted by the gonadotropes to differentially activate LH or FSH cells. The results of the project are expected to provide new insights into the evolution and function of gonadotropin regulation in vertebrates and yield new approaches to control and manipulate the reproductive axis of commercially important species.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'INTerdisciplinary ACTion for accelerating RD on and implementation of solid sorption heat pumps' (InterAct).

assistant: **Concept**

INTERACT: Interdisciplinair action for accelerating R&D on and implementation of solid-sorption heat pumps aims to advance the introduction of solid-sorption heat pumps to the market and to expand their application to industrial process heating as well as heating in buildings. According to the International Energy Agency (IEA), energy efficiency is the first option for reducing carbon dioxide emissions – before renewables and biofuels. Solid-sorption heat pumps are a very promising option for energy efficiency in heating and cooling, which accounts for 50% of our final energy use.Three project objectives have been defined:1. to develop solid-sorption reactors with a power density exceeding 1 MW/m3;2. to develop a strategic market plan in cooperation with manufacturers and end-users containing the required technical specifications for solid-sorption heat pumps and an approach to overcome the main non-technological challenges;3. to maximize impact of this & other related solid-sorption heat pump project results.This work will enhance the research and innovation skills of the applicant, providing him with collaborative international research experience at the highest level and new career perspectives. The collaborative research undertaken is in the overall area of the Rational Use of Energy and Renewable Energy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Decoding alpha motor neurons diversity and selective vulnerability to disease' (MOVEMeNt) targeting Horizon 2020.

assistant: **Abstract**

Alpha motor neurons (aMN) are a clinically relevant neuronal population that selectively degenerates in neuromuscular diseases, including amyotrophic lateral sclerosis (ALS) and spinal bulbar muscular atrophy (SBMA). Distinct classes of aMNs (SFR, FFR and FF) degenerate at different rate in these diseases, with the fast fatigable (FF) MNs degenerating first. The molecular mechanisms underlying this selective vulnerability are only partially known. Understanding the molecular logics that shape the identity and function of aMN subtypes in vivo is directly relevant to the development of novel therapeutic strategies. Here I propose to harmonically integrate my solid background in dissecting the molecular fingerprints of distinct neuronal subtypes in adult mice by undertaking new technologies I pioneered at Harvard University, with new skills and knowledge I will build at the Host Institution, which will be critical for the successful achievement of my goal. The overreaching goal of MOVEMeNt is to identify the molecular substrate of disease vulnerability in aMNs. I will (Aim 1) isolate and FACS-purify aMN-nuclei from adult mouse spinal cords, based on the specific expression of aMN markers. Single cell transcriptomic analysis will reveal class-specific molecular fingerprints, including factors playing key roles in suptype-specific development, function, and disease vulnerability. I will also (Aim2) analyze the transcriptional changes of differentially vulnerable aMN classes upon retrograde labeling and functional denervation by neurotoxin intoxication. This work will return candidate genes directly controlling terminal sprouting and remodeling, critical steps that disease-resistant aMN subtypes normally undertake for neuronal loss compensation upon insult. More broadly, I ai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Phytoplankton Towards Valorization of Ammonia-containing Liquid for Upgraded Economy' to be submitted under Horizon Europe.

assistant: **Abstract**

Unicellular small plants, microalgae and cyanobacteria, have a great potential to valorize wastewater by producing high-value biomaterials using the contained nutrients. However, a high concentration of ammonia in wastewater exhibits strong toxicity to microorganisms and prevents the successful cultivation of algae. While dilution is the most prevalent solution, large consumption of freshwater resources is costly and not sustainable. Therefore, this project aims to develop a novel method to detect algal ammonia inhibition by fluorescence monitoring, which will enable direct feeding of undiluted ammonia-containing wastewaters by controlling the feeding rate. In this project, appropriate fluorescent methods will be screened first, and the screened methods will be applied to algal cells exposed to various types of inhibition. A multivariate statistical model will be constructed to distinguish ammonia toxicity from other inhibitions. For improvement of feasibility, a low-cost fluorescent monitoring device shall be also developed. Finally, the developed methods and devices will be integrated into a long-term ammonia feeding control experiment to evaluate the feasibility. During the implementation of the research project, the candidate will receive training both from the host institution (Universidad de Valladolid; UVa) and from the Centre Algatech (CA) where the external advisor belongs to. The candidate will further develop skills in process engineering in the training from UVa and learn the mechanisms of fluorescence from CA. The expected results of the project include a fluorescent algal toxicity identification tool, a low-cost fluorescent monitoring device, and the ammonia toxicity control protocol, all of which have a strong impact on the field of wastewater treatment,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Overcoming PAncreatic cancer immunotherapy resistance: developing PYRimidine receptor antagonists' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The introduction of immunotherapy revolutionized cancer treatment, nevertheless, pancreatic cancer is still an omen of death with a dismal 5-year survival rate. Improvement of the current therapies for pancreatic cancer patients is thus an unmet medical need. The research we performed for the ERC CoG ImmunoFit identified novel metabolic pathways shaping the tumor microenvironment toward immunosuppression. Our latest publication in Nature Cancer characterized the CDA-UDP-P2Y6 axis as a major determinant of pancreatic cancer immune escape. With this PoC grant, we want to start the valorization of our findings, generating first-in-class P2Y6 biological blockers. Characterization of the metabolic crosstalk between cancer cells and the immune infiltrate, identified the UDP-elicited, P2Y6-dependent pathway as the most promising target to induce strong anti-tumor response and immunotherapy sensitization at minimal risk of side effects and generation of resistance. Evaluation of the current landscape of small molecules available for P2Y6 inhibition highlighted the urgent need for an out-of-the-box approach to generate a new class of molecules suitable to target this pyrimidine receptor in vivo. Here, we will take advantage of the specific know-how present in our host institute to generate (in collaboration with the VIB drug discovery center) VHH nanobody blockers. The feasibility of this ambitious project is ensured by (I) the strong results supporting the scientific rationale, (II) the compelling freedom-to-operate analysis, (III) the keen evaluation of the landscape of competitors as well as (IV) the presence of an outstanding experience, within our institution, on GPCR-targeting nanobody generation.With this application, we aim to start the generation and validation of P2Y6
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Aircraft for Environmental and Forest Science' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Up-to-date environmental science builds upon of highly standardised monitoring networks and global scale earth observations. But a missing scale in ecosystem monitoring still exist to properly bridge observations which are made at the leaf/canopy to the global scales. Aircraft and airborne sensors are ideal to operate at such “missing scale”.  Aircraft can be used to operate a range of sensors to monitoring atmospheric properties along vertical profiles, to perform surface flux measurements using airborne eddy covariance techniques and to deploy different types of remote sensing equipment.  Airborne science has considerably grown over the last few years, together with the advent of a new generation of airborne sensors. Despite recent efforts such as the Eufar Project, the use of airborne platform for environmental research still remains limited. The reason for this may be found in the existence of a major cultural gap between users and providers. AIRFORS is designed to fill this gap bringing together a public organization engaged in environmental research (FEM) and a private company (AT) with excellent records in conducting airborne measurements and campaign and in operating up-to-date airborne sensors. In this way it will contribute substantially to the development of a transnational public-private partnership aimed at the promotion of unique earth observation and atmospheric measurement infrastructure, at multiple scales.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Photonic Libraries And Technology for Manufacturing' (PLAT4M) under Seventh Framework.

assistant: **Objectives**

Silicon with its mature integration platform has brought electronic circuits to mass-market applications - our vision is that silicon photonics will follow this revolution. Over the last years silicon photonics has seen a tremendous increase in research output, leading to commercial exploitation potential. Most of these efforts have been devoted to the development of elementary building blocks, rather than the fabrication of complete Photonic Integrated Circuits which are needed to support the large potential markets. Upgrading existing platforms to become compatible with industrialization is now essential and requires efforts on streamlining and stabilizing the design and process flows, by taking into account design robustness, process variability and integration constraints.Europe's silicon photonics community has demonstrated a worldwide leadership with both new scientific discoveries and excellent CMOS photonics R&D facilities.PLAT4M's objective is to bring existing silicon photonics research platform to a maturity level which enables seamless transition to industry, suitable for different applications fields and manufacturing volume levels.Progress on three fronts is needed:1 Mature technologies and tools- Establish scalable Electrical-Optical co-design capability- Stabilize elementary building blocks, focus on process integration and common testing procedures- Develop packaging processes that support high volume manufacturing2 Validate each platform with application-driven test vehicles- Fabricate representative demonstrators in various applications fields3 Prepare and evaluate the next generation platform- Assess advanced processes with future technology nodes and scalability to high integration complexity<br/>PLAT4M gathers leading European R&D institutes and CM