RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New Horizons for Mass Spectrometry' (HORIZOMS), addressing dissemination and exploitation.

assistant: **Impact**

This project of basic research in chemistry tackles the challenge to close the wide gap between chemical and physical processes occurring in liquid solution and sophisticated studies of model systems in the idealized gas phase. By such the project aims to reach a convergence between the microscopic and macroscopic world. To this end, the planned research will span the range from isolated atoms in the high vacuum to the real species present in solution. Specifically, the proposal is focused on:- Ion solvation in dipolar media (e.g. aqueous salt solutions)- Influence of sequential solvation on redox processes (relevant in corrosion, for example)- Mechanisms by which metal catalysts facilitate chemical reactions (e.g. polymerizations)In order to address these tasks, the PI will combine his profound expertise in gas-phase methods  with well-established techniques from solution chemistry for the development of new and innovative coupling techniques which will allow to derive direct correlations between micro- and macroscopic properties. A particular highlight is the planned online-coupling of electron paramagnetic resonance (EPR) with electrospray ionization (ESI) mass spectrometry, which is unique worldwide and offers the exploration of new dimensions for both, EPR methods and ESI mass spectrometry.While the project is located in chemical sciences, physical-organic chemistry in particular, the prospects of the proposal range not only far beyond the PI's specific field of specialization into other areas of chemistry, but due to the enormous relevance of ion solvation, redox processes, and catalysis also into biological, physical and geological sciences with implications up to our daily life.The PI has excellent publication records with >330 scientific papers, >7800 citations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Systematic Chemical Genetic Interrogation of Biological Networks' (SCG), addressing dissemination and exploitation.

assistant: **Impact**

Recent genome-scale studies have revealed the massive redundancies and functional interconnectivities encoded by the genome. For example, the budding yeast Saccharomyces cerevisiae is predicted to harbor 200,000 synthetic lethal interactions. This genetic density has profound implications for both understanding the architecture of living systems and drug discovery. In particular, the dense connections of biological networks mandate a multi-node strategy to selectively manipulate any given biological response, whether it be to probe system level properties or for therapeutic intervention in human disease. By analogy to Ehrlich s  magic bullet  concept, we term this approach the  magic shotgun . We propose to systematically identify chemical-genetic interactions that selectively disrupt any specific mutant genotype and chemical-chemical interactions that selectively kill pathogenic species. Our five main objectives are: (i) construct a comprehensive Chemical Genetic Matrix (CGM) of small molecule-gene interactions in order to predict chemical synergies and manipulate network function in a species-specific manner; (ii) elaborate the CGM with a set of ~5,000 yeast bioactive molecules derived from high throughput/high content screens; (iii) identify small molecule combinations that modulate stem cell and cancer cell renewal and differentiation; (iv) define compound mechanisms of action by functional genomics; (v) integrate chemical-genetic, genetic and protein interaction datasets to predict gene function, small molecule targets and network properties. This research will cross-connect genetic pathways through chemical space, identify species-specific combinations of agents as therapeutic leads and provide a repository of small molecule probes for cell biological and systems-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding Collaboration in 3D Virtual Environments' in the context of a Seventh Framework call.

assistant: **Objectives**

The proposed research aims to advance our understanding of virtual teamwork in 3D collaborative virtual environments (CVE) that have gained increasing importance in global organizations and higher education institutions, and are subject to an emerging interdisciplinary field of research. CVE have been developed to facilitate cross-border collaboration and to overcome the issues associated with traditional collaboration tools. Team members are embodied as avatars, communicate via chat and audio channels, and can jointly look at and manipulate objects in a shared virtual space. However, it is still unclear whether the findings obtained in traditional small group research and earlier virtual team studies can be applied to embodied collaboration in CVE. Our goal is to investigate group interaction processes and outcomes in physical and virtual environments in order to examine how different media affect group behavior and under what conditions which medium is most effective. We use a mixed-method approach combining behavioral observation and self-report data, and develop an innovative methodology that makes it possible to automatically and unobtrusively collect data on group behavior in CVE interactions. The proposed research integrates findings from a large-scale international field study and experimental laboratory studies. While the field study focuses on cross-cultural aspects of collaboration in CVE, observation of long-term group interactions and project work, the experimental studies are designed as a media comparison using different task types and short-term observation of ad-hoc groups. Several interrelated research objectives are formulated for a systematical investigation of behavioral patterns and psychological effects that emerge from group interactions in virtu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Energizing Futures: Investigating the Infusion of IT and Design into Novel Foresight Practices'.

assistant: **Objectives**

This project advances applied and theoretical research into novel foresight methods. Taking the governance of emerging energy technologies as a case, this research investigates scenarios mediated through cutting-edge gaming, visualization, simulation and design techniques. This project involves two phases of qualitative research to empirically investigate the make-up, impact and products of novel foresight methods employed in the energy sector. Drawing on perspectives of anticipation, materiality and governance in the field of Science, Technology and Society (STS), this project seeks to 1) create a taxonomy of mediated scenarios; 2) characterize the nature and workings of such innovative foresight practices; and 3) develop two in-depth case studies involving the use of such scenarios in the field of energy in order to reveal the varied configurations of agency, temporality and culture inscribed in the practice. Through these inquiries, this project builds up STS scholarship on anticipation and contributes to understanding best practices of foresight by elucidating the nature and workings of novel methods. Drawing on a strong existing research program and a well-developed international network of scenario practitioners and interdisciplinary scholars, this research is situated within the Technology and Innovation Management Division at the Danish Technological University’s Department for Management Engineering with Professor, Dr. Per Dannemand Anderson as the scientist in charge.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Screening and breeding for resistance of pepper (capsicum annuum l.) to phytophthora capsici leonian'.

assistant: **Innovation**

Phytophthora blight of pepper is of great economical importance worldwide. For effective control resistant cultivars are needed. The aim of the proposal is to collect a set of morphologically and genetically distinguishable strains of P.capsici, optimise a bioassay for breeding purposes and screening available breeding material. Subsequently, both countries will be able to breed varieties with commercially relevant levels of resistance as an alternative to chemical control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dissecting the molecular mechanisms of cellular heterogeneity controlling infection-associated development in plant pathogenic fungi' under Horizon Europe.

assistant: **Concept**

Clonal microorganisms display cellular heterogeneity at the transcriptional level, to survive under unfavourable conditions or differentiate into specialised structures. This is the basis of antibiotic and fungicide resistance, but very little is known about how cellular heterogeneity originates and operates in the infection biology of agricultural fungi. Magnaporthe oryzae is one of the most devastating fungal pathogens in the world that destroys enough rice to feed 60M people every year. It produces ~50,000 new spores a day from a single lesion in the fields, but it remains unknown whether they are transcriptionally different. Spores contain three cells that display cellular heterogeneity between them during appressorium development, a specialised cell necessary for infection. Two of the cells undergo autophagy rapidly and the third undergoes a mitotic division leading to the formation of the appressorium. The mechanism by which cellular heterogeneity operates in spores has never been elucidated. This proposal will identify, for the first time, the molecular mechanisms driving cellular heterogeneity and genes subjected to it. An unparalleled resolution of the infection-associated developmental program of individual spore cells will be obtained by scRNA-seq, which will identify a cohort of virulence factors critical for infection. I propose that the underlying mechanism of cellular heterogeneity is the cell cycle, through the activity of Cyclin Dependent Kinases (CDKs) and a novel group called non-PSTARE CDKs, reported to be regulators of transcription in other organisms. By a state-of-the-art chemical genetic approach combined with phosphoproteomics, their role and signalling pathways will be determined. Overall, with this proposal, novel components associated to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SNS COLLABORATIVE OPERATIONS AND OUTPUT OPTIMISATION' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The SNS CO-OP project is devoted to supporting and facilitating the activities of the SNS Initiative under the Smart Networks and Services Joint Undertaking (SNS JU).  The SNS CO-OP project will achieve this by orchestrating and organising strategic activities, in collaboration with the SNS JU Office and the 6G Industry Association, to capture and promote the European Industry view on 6G, the achievements of the 6G SNS initiative and projects, and to promote the ambitions of the SNS JU. The SNS CO-OP project will build on the strengths and assets of the platforms and communities, established through the SNS OPS and SNS ICE work, to stimulate and align complementary activities across the wider community of 6G SNS stakeholders. SNS Co-Op will also ensure the long term continuity of the SNS facilities for subsequent phases of the SNS JU. In addition, the SNS CO-OP project will provide the support for the EUCNC & 6G Summit events in 2025 and 2026 building on the 6GStart achievements and experience. The SNS CO-OP project will provide an experienced competent project team that builds on the recent experiences of the SNS OPS and SNS ICE projects team to guarantee a seamless handover of all SNS support activities for maximum efficiently and value.  The SNS CO-OP project proposes a comprehensive workplan that, from the experience of the participants, will deliver the expected outcomes and impacts as specified in the work programme.  Particular care was taken to dimension the tasks appropriately for the likely scale and significance of the contributions from the projects.  The SNS CO-OP team will use measurable parameters to regularly assess the dissemination and communication effectiveness which will facilitate monitoring and improving the suitability and quality of the project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'RNA localization in bacteria' in the context of a Horizon 2020 call.

assistant: **Objectives**

In eukaryotic cells mRNAs can be localized to specific places within a cell to achieve protein synthesis with spatiotemporal control. Recently, I and others have shown that prokaryotes can also target mRNAs to specific parts of the cell. However, these studies have been restricted to a limited number of mRNAs and were performed with Gram-negative bacteria, and due to the serendipitous nature of these discoveries and conflicting results, it is not clear how widespread mRNA localization is in a bacterial cell and what conserved mechanisms are playing a role. To investigate this, I will first employ a novel CLIP-seq-inspired deep-sequencing-based approach to gain an unbiased view of mRNAs enriched at the cell periphery and cell poles of the Gram-positive model bacterium Bacillus subtilis. This dataset will reveal the scope of mRNA targeting by the Signal Recognition Particle (SRP) and will reveal mRNAs that use another mechanism for cellular targeting. In addition, classic CLIP-seq experiments will be used to identify mRNAs that use the cytoskeleton and other morphological proteins for targeting. As a complementary approach, I will assess the localization of mRNAs coding for different classes of localized proteins (polar, cell division, cytoskeletal, membrane, secreted, motility, nucleoid and chaperone proteins) using the established fluorescence in situ hybridization (FISH) technique. Information obtained from these experiments will subsequently be used to investigate the role of protein translation, RNA sequences, genome location and cell morphology in mRNA localization, to gain functional insight into the mechanisms responsible for this basic morphogenetic process.


**Keywords:** RNA localization, Cytoskeleton, RNA binding proteins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Mexican leech Haementeria officinalis and its nutritional symbiont as a model system for the study of strict blood-feeding animal-microbe symbioses and bacteriocyte development' (LEECHSYMBIO), addressing dissemination and exploitation.

assistant: **Impact**

Strict blood-feeding leeches are confronted with a strong B-vitamin deficiency and thus rely on bacterial symbionts to supplement their unbalanced diet. Recent evidence showed that the Mexican leech Haementeria officinalis houses in a distinct specialised organ intracellular Providencia siddallii symbionts, which have a highly reduced genome but maintained genes required for B vitamin biosynthesis. The aim of this proposal is to establish this leech as a model system for studying the intricacies of nutritional blood-feeding symbioses. The genomes of Providencia symbionts of 4 additional Haementeria species will be sequenced and analysed to identify core-metabolic pathways and to reconstruct the evolutionary history of this symbiosis. A draft genome sequence of the Mexican leech Ha. officinalis will be determined, providing unique insights into metabolic complementarity. Comparison with the available genome of the related non-blood-feeding leech Helobdella robusta will facilitate identification of genomic determinants of the acquisition/loss of the bacteriome and the blood feeding habit. Bacteriome development and colonization will be investigated using different developmental stages and advanced microscopy techniques. Host control and nutritional role of the symbiont will be studied using isotope probing experiments and state-of-the-art chemical imaging and metabolomics methods. This project will provide comprehensive insights into a nutritional symbiosis in medically relevant blood-feeding animals, including the evolution of specialised symbiosis organs and metabolic interactions between both partners. It will bring together a postdoc with a strong background in bioinformatics and bacterial symbionts with a host lab focused on experimental and molecular analysis of mic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Green Intelligent Affordable New Transport Solutions' to be submitted under Horizon Europe.

assistant: **Abstract**

To provide affordable and accessible mobility solutions to both emerging and advanced markets the GIANTS (Green Intelligent Affordable Nano Transport Solutions) project aims to develop a completely new electric vehicle platform. The platform is based on user demands and will be demonstrated and validated in use cases in both emerging and advanced markets showcasing the practicality of GIANTS technology. Rather than focussing on the development of a typical skateboard-solution common in the automotive sector, GIANTS offers a much more flexible and mission tailored approach: It is built on a set of technology solutions, which together allow to produce light electric vehicles (L5, L6 and L7) suited for urban traffic solutions. It offers modularity, scalability, and interoperability, and features innovative charging and energy optimization solutions. The platform will include a lightweight, blind mating and portable 48 V battery, a scalable e-drivetrain, a standardized vehicle control system, and roof solar panels. A vehicle configuration tool will also be available to enable 3rd parties to design vehicles based on the platform. The success of the platform will be assessed in terms of platform usability, manufacturability, vehicle operation, user acceptability, environmental benefits, and business viability. Additionally, a concept for recycling, reuse and refurbishment will be developed.GIANTS will reduce the cost of ownership for electric vehicles and provide climate-neutral solutions for urban transport that are user-friendly, energy efficient, and can improve air quality, thus the project will increase the user acceptance and lead to EU leadership in world transport markets. Demonstration activities with prototypes are expected to raise awareness of the GIANTS technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Integrative MSCA Achievements and Networks for Unified Strategies'.

assistant: **Innovation**

IANUS aims to maximize the strategic impact of the Marie Skłodowska-Curie Actions (MSCA) on the European Union's Missions and the European Research Area (ERA). The project will conduct a large-scale portfolio analysis of all projects funded under Horizon 2020 and Horizon Europe, using advanced computational methods to uncover features and patterns across projects that are not identifiable through standard analytical approaches. This analysis will identify thematic clusters, particularly those related to the EU Missions, and estimate the contribution of MSCA projects to these missions. Additionally, the portfolio analysis will explore the evolution of research themes and emerging trends over time, tracking the most significant trajectories.Building on this analysis, the project will develop pilots for the two largest EU Missions: Mission 2 (Cancer) and Mission 4 (Smart Cities). It will identify projects suitable for survey analysis and pilot in-depth case studies to uncover good practices, success stories, obstacles, and solutions in MSCA projects, particularly regarding researchers' intersectoral cooperation, training, skills development, and ability to address societal challenges, including those covered by the EU Missions. An agent-based model, co-designed with stakeholders, will simulate the large-scale effects of scientists' bottom-up adaptive responses to potential policy interventions in artificial simulation scenarios.Finally, the results will form the backbone of policy development workshops and events with stakeholders, aimed at developing recommendations to enhance the policy impact of the MSCA, the exploitation of MSCA project results, intersectoral cooperation, and researchers' skills and career development. Through extensive stakeholder engagement and the d