RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sleep genes and Circadian rhythm in dementia prevention' (CLOCKED), addressing dissemination and exploitation.

assistant: **Impact**

Changes in sleep patterns are common among people with dementia, however why short (≤6hrs) or long sleep (≥9hrs) duration is less favorable for dementia, remains unknown. Given that approximately 46% & 44% of variability in sleep duration is explained by genetics, it is pertinent to consider genetic influences when understanding the mechanisms contributing to sleep-related risk for dementia. In addition to sleep, there is growing interest in the relationship between circadian rhythms, the 24-hour cycles of body & dementia. Links between Alzheimer’s’ dementia and the circadian system are suggested by common observations that an early symptom of Alzheimer’s’ dementia is fragmented sleep/wake patterns with increasing night\time activity and daytime naps. Even among individuals who are cognitively intact, altered circadian rhythms of motor activity have been linked to amyloid pathology; the hallmark of Alzheimer’s’ dementia. There is some evidence linking weakening circadian rhythm to dementia, yet it is not clear whether disruption of clock contributes to incidence dementia. In CLOCKED, I will use data from the Swedish Twin Registry with over 20 years of follow-up, the largest twin registry in the world to assess if sleep polygenic risk score influences the risk of incident dementia (overall, Alzheimer’s’, vascular) & examine whether differences in dementia risk are influenced by a genetically predicted sleep or sleep driven mainly by non-genetic factors, i.e., environmental lifestyle factors. Using accelerometry data on around 100,000 participants from the UK Biobank data, I will assess the relation of accelerometer-assessed circadian rhythmicity with incident dementia & quantify dementia risk stratified by sex, ethnicity, socioeconomic status, shift work, lifestyle facto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanisms of actomyosin-based contractility during cytokinesis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cytokinesis completes cell division by partitioning the contents of the mother cell to the two daughter cells. This process is accomplished through the assembly and constriction of a contractile ring, a complex actomyosin network that remains poorly understood on the molecular level. Research in cytokinesis has overwhelmingly focused on signaling mechanisms that dictate when and where the contractile ring is assembled. By contrast, the research I propose here addresses fundamental questions about the structural and functional properties of the contractile ring itself. We will use the nematode C. elegans to exploit the power of quantitative live imaging assays in an experimentally tractable metazoan organism. The early C. elegans embryo is uniquely suited to the study of the contractile ring, as cells dividing perpendicularly to the imaging plane provide a full end-on view of the contractile ring throughout constriction. This greatly facilitates accurate measurements of constriction kinetics, ring width and thickness, and levels as well as dynamics of fluorescently-tagged contractile ring components. Combining image-based assays with powerful molecular replacement technology for structure-function studies, we will 1) determine the contribution of branched and non-branched actin filament populations to contractile ring formation; 2) explore its ultra-structural organization in collaboration with a world expert in electron microcopy; 3) investigate how the contractile ring network is dynamically remodeled during constriction with the help of a novel laser microsurgery assay that has uncovered a remarkably robust ring repair mechanism; and 4) use a targeted RNAi screen and phenotype profiling to identify new components of actomyosin contractile networks. The results from th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'StarTric - A novel transcatheter medical device to treat Tricuspid Regurgitation' (StarTric).

assistant: **Innovation**

Tricuspid Regurgitation (TR) poses a significant health challenge, affecting millions worldwide. Current treatment options, primarily open-heart surgery, come with inherent risks and are often unsuitable for frail patients. StarTric has pioneered a transcatheter device tailored to the intricate task of addressing TR. Drawing inspiration from the highly successful open-heart ""clover"" technique, this innovative device offers a minimally invasive alternative for TR repair. The StarTric device will reshape the tricuspid valve into a clover-like configuration, effectively restoring proper valve function. By replicating the efficacy of the clover procedure through transcatheter means, StarTric's solution holds immense promise in transforming the lives of countless patients globally. To bring this breakthrough solution to patients in need, StarTric requires funding support to accelerate development, clinical trials, regulatory approval and commercial efforts.""


**Keywords:** Cardiac healthcare, tricuspid regurgitation, transcatheter therapy, cardiology, heart valve repair, cardiovascular, medical devices, innovative treatments, healthcare, cardiac health, medical innovati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Dysfunctional mitochondria as a neuronal pathogen'.

assistant: **Innovation**

The symbiosis between the mitochondrion and the ancestor of the eukaryotic cell allowed cellular complexity. Due to its archeobacterial origin, mitochondria has been posited as a potential source of molecules that can elicit cellular responses to pathogens. Among other key functions, mitochondria generates most of the energy required by cells. Alterations in components of the mitochondrial energy-generating machinery lead to primary mitochondrial disease (MD), a group of highly invalidating human conditions with no effective treatment. High-energy-requiring cells, such as neurons, are especially affected in MD. However, not all neuronal populations are equally affected and the molecular determinants of this susceptibility are currently unknown. Recently, Quintana´s lab uncovered that GABAergic neurons in the Globus Pallidus (GPe) of a mouse model of Leigh syndrome (LS) are particularly sensitive to MD leading to fatal encephalopathy, recapitulating the human pathology. In addition, unpublished results of the host group showed that this neuronal population develop a robust cellular antiviral-like response elicited by mitochondrial double-stranded RNA (mtdsRNA). Nevertheless, the contribution of mtdsRNA release in the MD progression has never been defined. Thus, the main goal of MitoTROJAN is to identify the effect of mtdsRNA-induced neuropathology in the context of mitochondrial dysfunction with the overarching goal of providing novel targets for the treatment of MD. By combining mouse genetics with cutting-edge molecular biology and multi-omics approach, I will carry out a multidisciplinary strategy to i) parse the molecular mechanisms of mtdsRNA-induced neuropathology and ii) characterise the antiviral response-induced protein shutdown in affected neurons. Overall resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Outcome and impact of specific treatment in european research on melanoma (OISTER)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Human melanoma is highly resistant to any kind of treatment, but the underlying reasons are largely unknown. OISTER aims to collect tissue samples and cell lines together with relevant clinical data in order to correlate the tumour characteristics with the clinical information, especially response to treatment with the final objective of using this knowledge to enhance treatment success in this refractory disease. This will be achieved by analyses at the genetic and proteomic level and correlation of the results with the clinical data using artificial neural network bio informatics programs. Integration of pre-existing md newly-built data bases with ESTDAB, an EU-funded infrastructure project, aimed to establish the largest collection of fully-characterised melanoma cell lines in Europe and the world, will provide tools to identify new biomarkers and tumour-associated antigens associated with prognosis and responsiveness to treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European thematic network on indicators of social quality' in the context of a Fifth Framework call.

assistant: **Objectives**

The main purpose of the proposed network is to provide somereliable and robust benchmarks for the social development of the EU. It will do so by operationalising the innovative concept of social quality, introduced in 1997, in the form of specific social indicators. These indicators will be used to assess the current levels of social quality in different Member States and the impact of social-economic transformations on the quality of life of European citizens. The network addresses the issue at the heart of the Fifth Framework programme: the improvement in the quality of citizen's daily lives, as well as the practical problems faced by European and national policymakers with regard to understanding and evaluating social quality. The network will also provide European scientists with a framework to conduct comparative research. Finally operationalising the concept of social quality will open the way for citizens to be active and responsible participants in the processes of socio-economic change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Concept of Operations for EuRopean UTM Systems' (CORUS) under Horizon 2020.

assistant: **Objectives**

The drone business sector is growing rapidly, but in Europe today is held back by the absence of a harmonized approach for the integration of drones into Very Low Level (VLL) airspace. The CORUS (Concept of Operation for EuRopean UTM Systems) project gathers experts from aviation (manned and drone), research and academia to develop a reference Concept of Operations (CONOPS) for UTM (UAS Traffic Management) in VLL airspace in Europe.Building on the state-of-the-art, CORUS will develop an operational concept enabling safe interaction between all airspace users in VLL considering contingencies and societal issues. Specifically CORUS will:1. Establish a CONOPS for nominal situations, developing use cases for major scenarios2. Address drones operations in the vicinity of airfields and controlled airspace and for transfer between controlled and non-controlled airspaces.3. Describe how losses of safety in non-nominal drone situations can be minimized.4. Examine non-aviation aspects, identifying key issues for society and offering solutions to ease social acceptance5. Identify necessary technical developments, quantifying the level of safety and performance requiredThe broad acceptance of the CORUS CONOPS is paramount. To this end CORUS will establish a “UTM community Network” drawing on a wide range of stakeholders, to guide and review the development through a series of workshops. A subset of the “UTM community Network” will form an Advisory Board to review draft documents and answer questions. Through these bodies coordination with other ongoing research and rulemaking initiatives from the European Commission, EUROCAE, EASA, JARUS and NASA’s UTM research project will be ensured, as well as the regular interaction with the Work Area 2 projects of the same Call.Comprehensive c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metabolic correction of hepatoerythropoietic porphyria by retrovirus- mediated gene transfer' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Hepatoerytropoietic porphyria (HEP) is an inherited metabolic disorder characterised by the accumulation of porphyrins resulting from a deficiency in uroporphyrinogen decarboxylase (UROD). This autosomal recessive disorder has been chosen as a model of hematopoietic disease amenable to gene therapy. The disease is severe, starting early in infancy with no specific treatment and gene therapy would represent a great therapeutc improvement. A gene transfer strategy in hematopoiefic cells using retoviral vectors is proposed. As first step, the efficiency of the viral constructs is tested on human fibroblasts and lymphoblastoid cells which are easy to obtain. At the next step gene transfer is performed in hematopoietic cells obtained from peripheral blood. In the different target cells, the integration of proviral sequences and their expression is checked in short term and long term cultures. In UROD deficient cells, the metabolic correction is analysed in terms of UROD activity and porphyrin accumulation. Finally, the most appropiate viral construct will be used further, ideally in an animal model of the disease, before the design of a human gene therapy clinical protocol.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Gravity, Chern-Simons extensions, Topology and Solid-state Physics applications' in the context of a Sixth Framework call.

assistant: **Objectives**

Advances in mathematics and physics have often occurred together - the development of Newton's theory of mechanics and the simultaneous development of the techniques of calculus constitute a classic example of this phenomenon. A more recent one is provided by topology on the mathematical side and (quantum) theory of fields in physics. Scientifically, this project is devoted to a novel approach to incorporate topological invariants, in particular the so-called Chern-Simons term, in gravitational physics, its ramifications, and to derive predictions which are testable by future space experiments or astrophysical data. By virtue of Black Hole analogues also applications to solid-state systems will be studied, thus establishing interdisciplinary links between otherwise only loosely connected branches of physics: mathematical physics, gravity, solid-state physics, cosmology and astrophysics. The main goal of this project is the establishment of a long-term collaboration by virtue of the scientific project outlined above. Such a long-term collaboration will be of mutual benefit for MIT and the physics community in Vienna for various reasons: student exchanges between these institutions can be organized with ease once a personal contact is established and provide a huge career boost especially for younger scientists. Moreover, experts from MIT can be invited exploiting the excellent visiting programs of the ESI in Vienna. This project will contribute to a solution of the brain drain" problem by transfer ring know-how and contacts from a renowned institution in the US, namely MIT, to a well-known institution in Europe, namely the Vienna University of Technology."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Rehabilitation and Diagnosis of Hearing Loss based on Electric Acoustic Interaction' (READIHEAR).

assistant: **Innovation**

Hearing loss is the most common sensory deficit in the elderly, and it is becoming a severe social as well as a health problem. Across the whole lifespan, from new-borns to the elderly, hearing loss impairs the exchange of information, thus significantly impacting everyday life, causing loneliness, isolation, dependence, frustration and communication disorders. Cochlear implants (CIs) are hearing prosthetics that stimulate the auditory nerve with electrodes placed inside the cochlea.  CIs are gradually being implanted in subjects retaining low-frequency residual hearing. In general, these subjects obtain large benefits in speech perception from electric acoustic stimulation, although large variability exists and some subjects do not benefit.  Therefore, it is highly desirable to create objective diagnostics to assess acoustic low-frequency hearing to indicate cochlear implantation, to monitor and preserve hearing during the implantation procedure and to understand the mechanisms related to electric acoustic stimulation benefits.    The ground-breaking nature of the READIHEAR project is to investigate the fundamental interaction mechanisms between electric and acoustic stimulation across the auditory pathway, from the cochlea up to the auditory cortex. The fundamental understanding will set the basis for a new generation of diagnostic devices of hearing loss that combine for the first time minimally invasive electric acoustic stimulation. Moreover, READIHEAR will assay a novel auditory prosthetic that makes use of the interaction mechanisms between acoustic and electric stimulation delivered through minimally invasive electrodes. These developments will be beneficial for a large population suffering from hearing loss across the whole lifespan, from young children who wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Precision tracking with tools from Astrophysics' to be submitted under Horizon 2020.

assistant: **Abstract**

In our ERC-funded project we have used interferometric techniques from radio astronomy to precisely localize bunches of cosmic ray particles rushing through our Earth atmosphere at light speed. Here we want to use this technique to provide precise and robust tracking of tracking of vehicles, such as robotic lawnmowers, ships and planes. Localizing vehicles as precisely as possible has become an ever more important aspect of modern day life, as is evident from the success of GPS. However, under certain circumstances GPS will not work well, either because the vehicle is indoors or the accuracy of GPS-systems is not sufficient. To achieve the feat of catching particles at light speed in our ERC project, we combined the knowledge from radio astronomy, particle physics and modern digital data processing. We developed solar-powered smart receivers linked over large areas into a single interferometer and developed software tools that allow us to do radio interferometric measurements in the presence of distorting signals. In the past, radio astronomical techniques were too compute- and power-intensive for commercial applications; however, the game changers are now powerful mobile phone processors developed for the consumer market. As a result we can in principle robustly localize radio sources to within a fraction of a wavelength – i.e., anywhere from millimetres to metres depending on the radio frequency. The concept is scalable, can be used to measure accurate locations over distances from metres to thousands of kilometres, and can be employed on earth or from space. The earth-based applications has a potential economic and social impact for instance via the tracking of objects (parcels or people) indoors, while the space-based application will allow for continuous tracking o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a shoe last with interchangeable toe manufacturing system' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The manufacturing of shoe lasts is one of the most important phases in footwear industry. Footwear manufacturers need to store a great amount of different lasts in order to manufacture the wide range of lasts to match the fashion needs. However it has been demonstrated that the only change of a single part, the toe, (remaining unchanged the rest of the last) is enough to fit fashion requirements. The objective of this project would be the development of an innovative last designing and manufacturing system for lasts with interchangeable toe. This system will reduce the stock of lasts needed by the footwear industry. Fashion requirements will be accomplished changing only the last's toe, allowing the standardisation of the rest. This system will increase direct costs savings as a result of labour costs (reduction of last's design time) and materials (reduction of lasts stock) so that improving competitiveness of SMEs from the footwear industrial sector.