RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Computational approaches to reveal the role of astrocytes in information processing and neural networks dynamics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Information about the external world is encoded in the brain through the dynamical activity of neuronal ensembles, so-called neural population codes.  Neurons, however, are not the only cell types making up the nervous tissue. Astrocytes interact with neurons at the synaptic and network level. Astrocytic intracellular calcium dynamics integrates and modulates surrounding neural activity over a wide range of spatial and temporal scales. Recent studies showed that these calcium transients encode information about external stimuli, and that this information is complementary to that encoded in neural activity, suggesting that astrocytes may play an active role in computations carried out in neural circuits. Here, I will investigate the role of astrocytes in shaping neural population, focusing on representations of space in the mouse the hippocampus during navigation. By using biophysically plausible network modeling and information theory I will characterize how the dynamics and information coding properties of networks of neurons are enhanced when they interact with astrocytes. The model will be constrained and guided by analysis of simultaneous dual-imaging recordings of neurons and astrocytes. Then I will consider new data, provided by the secondment lab, of longitudinal neural recordings during which astrocytic calcium dynamics was chemogenetically manipulated during the exploration of familiar and new environments over days. I will determine the causal role of astrocytes in neural information processing by using information theory and machine learning to analyze neural information coding when astrocytes are or are not perturbed. Then, I will use the data to construct biophysically plausible models of astrocytes contribute to the evolution of neural codes across days. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a methodology for rapid and flexible product development in multi-party cooperation involving smaller supplier companies' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Today, European supplier companies participating in their customers' development of new products are reporting a range of problems, leading to cost increases as well as delays which sometimes may jeopardise entire projects. The vast majority of these companies are in the SME range. Even when a supplier company does not perform product development, it is normally more or less involved in the development process. In some development phases, the need for communication may be very great. This situation is encountered by many small and mediumsized supplier companies throughout the European Union. It is also, however, a certified fact that many problems regarding such co-operation are still unsolved. Often, availabe in-house skill among suppliers is not utilised by customers in their development processes, leading to costly manufacture and less competitive end-products. Other problems experienced are frequent changes of specifications and difficulties in keeping prototypes and preproduction series up to date with the continuous flow of engineering changes made by-customer companies. Companies whose in-house resources for product development actually have been used in co-operative development projects are resporting additional problems as diffuse product specifications in terms of total cost and required level of quality and that participation in the customers' meetings consumes time and leads to high travelling expenses. A major RTD goal of this project is to develop a new methodology for rapid and flexible product development in customer/supplier networks, with the participation of several supplier categories (horizontal as well as vertical cooperation) enabling a reduction of the development-related costs of SME-size suppliers of 50 % and of the overall time-to-market for n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'IMGAME Commercial'.

assistant: **Objectives**

The idea is to bring to pre-commercial stage two marketable versions of the research software that has been built for use in Prof Collins’ ERC Advanced Grant ‘IMGAME’ (ERC-2010-AdG-269463):1) A new academic IMGAME Research Tool, potentially to be sold under licence to universities and other organisations engaged in social sciences research; and2) A popular game, with the working name Masquerade, which can be played via the internet,using computers or handheld communication devices.In 1950, the famous computer pioneer, Alan Turing, proposed what became widely known as the ‘Turing Test’ which involved testing a hidden machine’s ‘intelligence’ by comparing its written responses to those of a hidden human and the extent to which one group can pretend to be the other – tested over a series of games and measured by the summary statistic, the ‘Identification Ratio’ (IR) – indicates the extent to which that group understands the other.  The IR is a brand new measure of social integration and/or cultural understanding – we think it is the first new kind of quantitative measure in the social sciences since the social survey.The object of this proposal, ‘IMCOM’ (IMGAME Commercial), is to move one of the outputs of the core IMGAME grant, i.e. the game software we have developed, onto a pre-commercialisation stage through two commercial avenues as stated above.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Efficient and cost-effective PLASMA surface treatment method Efficient and cost-effective PLASMA surface treatment method for flexible FILtration materials used in the separation of immiscible liquids' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

PLUME Srl is an innovative company founded in 2016 as a spin-off from the Plasma Prometeo Centre of the University of Milano-Bicocca. Our main business thrust is developing and marketing innovative and high-tech products based on plasma processing. Although a start-up, Plume has a combined experience of more than 20 years of applied research carried out in plasma treatment, deposition and material functionalization. Over the past year, we have focused our work on plasma processes that modify the hydrophilic and hydrophobic properties of textile, technical textile and polymeric films, gaining sound experience in surface treatment and characterisation in various fields of applications.After identifying a gap in water-oil filtration systems, we have developed PLASMAFIL, an innovative plasma surface treatment process for flexible filtration materials for the separation of immiscible liquids such as oil and water. Applied on polymeric fabric or polymeric membranes, our plasma treatment modifies the surface tension, altering both chemical properties and morphology of the filtering material surface. This improves the efficiency and durability of water filtration systems. This is done in a cost-effective manner, as PLASMAFIL does not require heat, nor solvent or coatings, therefore saving energy, materials and money.This is particularly of relevance for the oil and chemical sector where industrials are under economic, environmental and regulatory pressure to improve their oily wastewater treatment. With PLASMAFIL, we have a vision of expanding our influence and becoming renowned global suppliers of surface treatment processes and treated materials. This will see us grow sustainably, generating €9.48M cumulative revenue by 2024, with a ROI of 2.45.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Travel, Environment, Sustainability: A Literary and Cultural History of Irish and Scottish Coastal Routes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

COASTAL ROUTES explores the deep history of human-environment relationships along the environmentally fragile Atlantic coasts of Ireland and Scotland through an interdisciplinary analysis of travel writing between 1770 and 1840. Offering the first comparative study of a neglected archive of Irish and Scottish travel texts from the period, COASTAL ROUTES will energise literary criticism beyond a nation-centred and imperial context by remapping the environmental geography of archipelagic Romanticism. It innovatively combines Environmental Humanities, Archipelagic Criticism and Geocriticism in order to contrast and examine the ways in which tourists construct landscape as a resource; consider how they reflect changing attitudes and values; and demonstrate how environmental narratives grew up around particular locations. COASTAL ROUTES makes a timely contribution to the UN’s Agenda 2030 as it sits at the nexus of Goals relating to sustainable economic growth, consumption and production patterns as well as sustainable development of marine resources. Understanding the historical development of culturally-informed values of the environment as developed in Romantic travel writing allows critical reflection on contemporary practices and future directions. As part of the dissemination plan, project findings will be communicated to the public via social media and a virtual exhibition. COASTAL ROUTES aims at intersectoral knowledge transfer by creating two travel e-brochures made freely available to Visit Scotland and Tourism Ireland for wider dissemination. Through the action, the ER will widen her research expertise, establish a new international network, and develop new skills in public engagement and impact to foster interdisciplinary and intersectoral knowledge transfer to st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Demonstration of 2nd Generation Vegetable Oil Fuels in Advanced Engines' (2NDVEGOIL) under Seventh Framework.

assistant: **Objectives**

Pure vegetable oil use as engine fuel has the potential for the most comprehensive ecologic, economic and social benefits of all biofuels. The production involves few process steps and can be done economically with small production units. The production process has only small energy losses and provides potential for additional income generation on farms, thereby strengthening rural economic structures. The challenges to be met by pure vegetable oil are engine adaptation, fuel quality control, emissions control and limits to overall production potential. State-of-the-art concepts allow for achieving EURO3 emission levels for road vehicles in specifically adapted diesel engines for rape seed oil fitting to the German pre-norm DIN V 51605. However, advanced biofuels should allow that emissions keep within the limits of the forthcoming EURO6 norm for road vehicles and EU Stage 4 / US Final TIER4 for non-road vehicles. This proposal covers research and demonstration on 2nd generation vegetable oil fuels in advanced engines. It follows a double strategy: engines as well as the fuel are adapted such that both match and the combination allows for achieving high engine performance at minimum fuel consumption fitting with most severe emission limits. The objectives are (1) to widen the range of considered oils, (2) to research on and demonstrate additives for vegetable oils, (3) to research on and demonstrate improved engine oils, (4) to achieve EU stage 4 / US TIER4 emission levels in medium-scale demonstration fleets running in France, Austria, Germany and Poland, (5) to transfer the engine and fuel concepts to hybrid engines, allowing to achieve forthcoming EURO6 emission levels, (6) to prepare proposals for future fuel standards. The outcome of the project includes advanced e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Investigation of the role of phytohormones and the endoreduplication process in maize endosperm development' to be submitted under Fourth Framework.

assistant: **Abstract**

The objective of the project is to understand the basis for maturation phase initiation during maize endosperm development when starch and protein accumulation occurs. The initiation of this process follows a marked change in the endosperm auxin/cytokinin ratio leading to endoreduplication of the central endosperm cells. Correct development of the endosperm and storage product accumulation is dependent on endoreduplication. We have recently isolated a maize kernel mutant (K10) characterised by smaller than normal seed size, reduced storage protein accumulation and failure of the endosperm cells to endoreduplicate. We intend to determine if this phenotype is linked to changes in auxin/cytokinin levels or their perception. We will also examine the levels of cell cycle markers in this mutant, some of which we will obtain by interaction cloning. Understanding the link between phytohormones, endoreduplication and storage product synthesis could provide the means to improve yield in maize and other cereals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Geometry and analysis for (G,X)-structures and their deformation spaces'.

assistant: **Innovation**

The study of geometric structures on manifolds finds its inspiration in Kleins Erlangen Program from 1872, and has seen spectacular developments and applications in geometric topology since the work of Thurston at the end of the 20th century. Geometric structures lie at the crossroads of several disciplines, such as differential and algebraic geometry, low-dimensional topology, representation theory, number theory, real and complex analysis, which makes the subject extremely rich and fascinating. In the context of geometric structures of pseudo-Riemannian type, the study of submanifolds with special curvature conditions has been very effective and led to some fundamental questions, such as the open conjectures of Andrews and Thurston from the 2000s, and the recently settled Labouries Conjecture. This project aims to obtain important results in this direction, towards four interconnected goals: 1. the study of quasi-Fuchsian hyperbolic manifolds, in particular leading to the proof of a strong statement that would imply the solution of the conjectures of Andrews and Thurston; 2. the achievement of curvature estimates of L^2-type on surfaces in Anti-de Sitter space; 3. the construction of metrics of (para)-hyperKhler type on deformation spaces of (G,X)-structures, and the investigation of their properties; 4. the study of existence and uniqueness of special submanifolds of dimension greater than 2 in pseudo-Riemannian symmetric spaces. The project adopts an innovative approach integrating geometric and analytic techniques, and the results will have remarkable applications for Teichmller theory and Anosov representations. In the long term, the proposed methodology and the expected results will lead to further developments in various related directions, for instance: the stu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Resilient steel frame against fire and seismic hazards' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Conventional seismic-resistant structures are designed to experience significant damage under moderate-to strong earthquakes and this results in socio-economic losses such as injuries, high repair costs and disruption of the building use or occupation. To address this issue, researchers have developed modern seismic-resilient frames that can avoid inelastic deformations (i.e. damage) in structural members. Fire is another type of loading, which can cause significant damage and collapse. Moreover, fire after strong earthquakes is also a highly probable catastrophic event as it has been seen after recent earthquakes (e.g. Indonesia 2009, Chile 2010). Despite the fact that the risk of fires is high after strong earthquakes, seismic resilient structural systems have not yet been studied against fire and fire after earthquake loading. This project will assess the behaviour of modern seismic-resilient self-centering post-tensioned steel frames against fire loading and will propose modifications of their structural details so that, apart from seismic resilience, fire robustness can be also achieved. The project aims to develop, for the first time, an innovative steel frame characterized by the unique combination of minimal damage seismic behaviour and robustness against fire and post-earthquake fire loading.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dissecting and Overcoming Innate Immune Barriers for Therapeutically Efficient Hematopoietic Stem Cell Gene Engineering' (ImmunoStem) targeting Horizon 2020.

assistant: **Abstract**

The low gene manipulation efficiency of human hematopoietic stem cells (HSC) remains a major hurdle for sustainable and broad clinical application of innovative therapies for a wide range of disorders. Indeed, high vector doses and prolonged ex vivo culture are still required for clinically relevant levels of gene transfer even with the most established lentiviral vector-based delivery platforms. Current and emerging gene transfer and editing technologies expose HSC to components potentially recognized by host antiviral factors and nucleic acid sensors that likely restrict their genetic engineering and contribute to broad individual variability in clinical outcomes observed in recent gene therapy trials. Nevertheless, specific effectors are yet to be identified in HSC. We have recently identified an antiviral factor that potently blocks gene transfer in HSC and have discovered small molecules that efficiently counteract it. This is the first example of how manipulating a single host factor can significantly impact gene transfer efficiencies in HSC but likely represents the mere tip of the iceberg of the plethora of innate sensing mechanisms potentially hampering genetic manipulation of this primitive cell compartment.  This proposal aims to identify the antiviral factors and innate sensing pathways that prevent efficient modification of HSC and to mitigate their effects using methods developed through a thorough understanding of their mechanisms of action. My approach builds on the innovative concept that understanding the crosstalk between HSC and viral vectors will instruct us on which immune sensors and effectors to avoid and how, with direct implications for all gene engineering technologies. Successful completion of this project will deliver broadly exportable nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'The insecure perspectives of the low skilled in the knowledge society'.

assistant: **Objectives**

The European Low-wage Employment Research network LoWER, started 1996 under FP4, proposes to continue its activities focusing on the uncertain position of the low skilled in societies increasingly functioning on the basis of formal knowledge, particularly for allocating jobs - and thus income and social and self-esteem. The network provides important links to new research including that of many European projects. It will consolidate its membership, broaden its base in the candidate countries and shift its f ocus. The study of changes occurring in the functioning of present-day labour markets and work organisations regarding skill contributes importantly to the understanding of developments towards and potential effects of a knowledge-based society. In the low -skilled and low-paid labour market the structures of time (part-time jobs), skill (overeducation and lacking training) and households (worklessness, inheritance) are evolving rapidly, with strong interactions, to the disadvantage of low-skilled persons an d social cohesion. The network will stimulate the study of these trends bringing together in the perspective of the low skilled (workshops, open-call conferences, expert groups, exchange of personnel) scholars who have built a tradition of research co-oper ation stretching well beyond the network. The work is organised in packages addressing 1) individual mobility & employer behaviour, 2) household behaviour & intergenerational transmission, 3) gender & skills and 4) skills & training - each contributing to the study of the above trends. Interestingly, levels, processes and trends differ significantly across countries (e.g. declining part-time employment in some countries) and much can be learned from international comparisons, including the U SA. They will also