RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Synthesis and evaluation of new macrocyclic compounds based on jatrophane scaffold' in the context of a Seventh Framework call.

assistant: **Objectives**

AbstractJatrophane are natural compounds isolated from Euphorbia (Euphorbiaceae, spurge family). More than 150 jathrophane have been isolated so far. The general structure is an highly functionalized trans-bicyclo[10.3.0]pentadecane skeleton. Jatrophanes possess a variety of different biological activities such as inhibitory activity on the mammalian mitochondrial respiratory chain, cell cleavage arrest, cytotoxicity against various human cancer cell lines, antiviral activity, antiplasmodial activity, microtubule interaction and cytotoxicity against human cancer cell lines. Most notably, they are inhibitors of the P-glycoprotein (Pgp), a membrane protein whose major function is the active transport of amphiphatic xenotoxins out of the cytoplasm. The over expression of the multi-drug resistance protein 1 (MDR1) gene (which encode for Pgp) contributes to the resistance of cancer cells against a large spectrum of anticancer drugs. Only natural occurring jatrophane have been investigated as modulator of multidrug resistance so far. Despite the large number of jatrophane isolated and the promising biological properties, the preparation this class of compounds can be regarded as a synthetic and biological challenge. The fellow has already an excellent background in synthetic chemistry.  This project will allow him to increase his experience and knowledge in natural products chemistry, carbohydrate chemistry, development of bioactive compounds as well as enhance his synthetic experience.  He proposes to join NUI Galway which is strategically developing strength in Biomedical Research, Cancer and Glycoscience, thus helping an objective 1 region of Europe to develop its research programme.  NUI GAlway will also offer a series of transferrable skills and personal development cour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A mechanistic understanding of Arctic River Methane Emissions', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Constraining the global methane (CH4) budget is an urgent need to predict future climate. Rivers are an important source of CH4 to the atmosphere, with surprisingly high rates of emissions in northern regions. The high emissions from Arctic rivers are driven by lateral inputs from surrounding land and are very sensitive to climate, but challenging to assess. Given the severe impacts of ongoing climate change at high latitudes, CH4 emissions from Arctic rivers have a large potential to further increase, but we are unable to quantify and predict future emissions due to a lack of process-based models that represent river CH4 emissions. The limitation arises from our poor understanding of river Arctic CH4 cycling, with a clear lack of mechanistic studies that are foundational to advancing process-based models. ARIMETH aims to address this issue, by initially generating the mechanistic understanding of Arctic riverine CH4 cycling. Subsequently, the project will develop the modelling tools to predict current and future CH4 emissions. To achieve this goal, the project will conduct a comprehensive approach, including a whole-stream warming experiment, high-resolution measurements with state-of-the-art CH4 sensors coupled with remote sensing data, pan-Arctic sampling campaigns to find the sources of CH4 using carbon radioisotopes, and developing deep-learning mechanistic models for river CH4 emissions. The outcomes of ARIMETH will offer ground-breaking insights into river CH4 cycling, spanning from the river itself to the catchment, and to pan-Arctic scale. Finally, ARIMETH will determine if CH4 emissions from Arctic freshwaters are underestimated when lateral fluxes to rivers and emissions are not accounted for. This is critical to predict future trajectories of global warming,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fashioning Power through South-South Interaction:  Re-thinking Creativity, Authenticity, Cultural Mediation and Consumer  Agency along China-Africa Fashion Value Chains' in the context of a Horizon Europe call.

assistant: **Objectives**

The project investigates how, in the context of the Belt and Road Initiative, Chinas global power is manifested, negotiated and resisted in peoples daily life in a South-South setting using fashion as an exemplary case. Fashion is recognised as a significant economic force globally and one of the most poignant indicators of cross-cultural exchange. By critically examining China-Africa networks of fashion production, trade and consumption, this project will theorise how fashion is created, circulated, valuated, and consumed in and through Global Souths Value Chains (Guangdong-Nairobi-Maputo), dissecting complex dynamics and expressions of power. Using a multi-disciplinary, multi-method, multi-sited, and multi scalar approach, the following questions frame this project and its four subprojects: 1) How are everyday fashion products designed and produced in China for African markets; 2) How do Chinese and Africans interact to valuate and trade fashion products for Kenyan and Mozambican markets; 3) How and by whom are cultural differences negotiated and mediated in the marketplace; and 4) What values, meanings and power do African consumers derive from consumption, and what ideas and constraints are imposed on them? This projects major contribution is threefold. Theoretically, it will move beyond a Western-centric epistemology to map the chains, restraints and materialities of Chinas power expansion through fashion. Methodologically, this project will synergistically collect and triangulate empirical information along complete South-South commodity chains through multi-sited ethnography, semiotic and visual analysis, individual and focus group interviews, and wardrobe archival studies. Empirically, it will provide evidence of how Chinese-African fashion industries impact upo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel methods for predicting preventing and treating attacks in patients with hereditary angioedema ((PREHEAT))' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Hereditary angioedema (HAE) is a rare, potentially lethal disease caused by the deficiency of Cl inhibitor. It is characterised by recurrent swelling of the skin (causing disfiguration), of the bowel (causing severe abdominal pain), of the upper airways (causing asphyxia). There is very low awareness to this disease; thus a minority of patients reach correct diagnosis and treatment. Small and dispersed case-list and lack of epidemiological data lessen the value of clinical studies and discourage research aimed to develop new therapeutic strategies. We propose the creation of a European research group on HAE composed by scientist, clinicians and associations of patients involved in the field of HAE. The project is aimed to improve the quality of life of HAE patients through:(i) creation of a European register for HAE; (ii) improvement of existing therapeutic resources (iii) identification of new targets for therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Achieving Good Environmental Status for maintaining ecosystem SErvices, by ASsessing integrated impacts of cumulative pressures'.

assistant: **Objectives**

GES4SEAS will inform and guide marine governance in minimizing human pressures and their impacts on marine biodiversity and ecosystem functioning, while maintaining the sustainable delivery of ecosystem services. This will be achieved through developing an innovative and flexible toolbox, tested, validated, demonstrated and upscaled, in the context of adaptive Ecosystem-Based Management (EBM). This will allow competent authorities to assess and predict the effect of multiple stressors (including climate change) and pressures from human activities, at the national, sub-regional, regional and European level. This will ensure they achieve Good Environmental Status (MSFD), and support different policies at national, European and global levels (e.g. BHD, Biodiversity Strategy, SDG). This will be achieved by integrating stakeholders and the key competent authorities in a Practitioner Advisory Board, in co-creating and validating the toolbox and the EBM approach. In this, we focus on real problem solving and following an iterative and incremental development approach. This will allow GES4SEAS to achieve Technological and Societal Readiness Levels 6, since our solutions will be tested and demonstrated at 11 Learning Sites (LSs) covering important regions and environments. These LSs have been selected to explore geographical specificities, in the four regional seas, with regards to the impacts of cumulative pressures (including climate change) on the functioning of ecosystems, and their capacity for providing ecosystem services, to ensure better management. This includes LSs to explore transboundary issues and a LS at pan-European scale, to explore comparability and harmonization across regional seas, and gain understanding on the functioning of transverse topics (e.g. invasive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SCRUTINIZING VIRUS-CELL INTERACTIONS: FROM ENSEMBLE TO SINGLE-MOLECULE STUDIES' (INTERACT).

assistant: **Innovation**

Viruses are nano-sized, genome-filled protein containers with metastable mechanical properties. They form by spontaneous self-assembly inside the crowded, heterogeneous environment of the infected cells. While structural characterization of viruses is becoming increasingly more refined, essential questions about the viral life cycle remain unanswered up to date. This includes: (i) how do the capsomeres (capsid proteins) rearrange during the infection cycle of a viral capsid? (ii) What are the interaction forces responsible for successful infection of viral capsids? (iii) Which kinetic parameters govern this process? To address these questions, the present proposal aims to understand the physico-biology behind the binding of viral capsids to their host cell membrane using human adeno virus as a model system. To accomplish these goals I will investigate the structural and mechanical properties of those proteins forming the viral capsids and measure the binding force to the targeted cell membrane. High-speed atomic force microscopy (HS-AFM) will allow me to directly observe the ensemble of proteins in action at high spatio-temporal resolution and under near-to physiological conditions. At the same time Single Molecule Force Spectroscopy (SMFS) will allow to measure directly the magnitude of forces involved in the interactions. Having access to the information on structure as well as to the unbinding dynamics of the capsid proteins, I will be able to build a kinetic model of the first steps of viral infection at the single-molecule level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Borelli Galaxy. Visualizing Galileo's Heritage (1635-1700 ca.)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

BorGal orbits around the figure of the italian physiologist, physicist, and mathematician Giovanni Alfonso Borelli (1608-1679). He was the only one among the Galileo’s disciples to cross the disciplinary boundaries and to apply the master’s teaching to the different branches of scientific research. Like Galileo’s, his sperimentalism mantained a strong theoretical and ‘ideological’ committment; he pursued with extraordinary energy and method an overall strategy to spread the credo of the new philosophy in all fields of scientific investigation, in all Italian Universities (especially in the Mediterranean area) and even in the ‘public sphere’. Despite his unquestionable value, this figure has not yet been the object of a monographic project. BorGal will accomplish this necessary task to make clear to everybody the importance of B.’s in the making of European scientific thought and community. I aim to achieve these goals by employing and enhancing Borelli’s still neglected correspondence, and in particular: to recover it by merging published, unpublished and still-to-be-discovered letters; to process the correspondance-data through the methodology proposed by the Mapping the Republic of Letters Project sited at Stanford History Department. Once in the US with the support of the GF, thanks to the powerful desktop application and programming languages for data visualization developed by the MRofL team with the support of the Stanford Center for Spatial and Textual Analysis, I will be able to map, chart ‘heuristically’ visualize and make visible to others the spatial multifaceted dimentions of ‘B.’s galaxy’ (places, people, works, letters, instruments, objects, information…), as well as the way ‘Galileo’s heritage’ took shape circulating across it. Last but not least, this B’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Probabilistic 3D surface matching for bathymetry based Simultaneous Localization and Mapping of underwater vehicles' under Seventh Framework.

assistant: **Concept**

The development of Autonomous Underwater Vehicles (AUVs) has offered numerous advantages, but has also presented new challenges. Free from the burden of an umbilical cable connecting them to the support ship, they are a quantum leap from widely used Remotely Operated Vehicles (ROVs) providing a stable platform for the new high resolution scientific sensors and reducing the operational costs. One of the most significant challenges is the problem of underwater navigation or, in other words, how to determine the vehicle's position within the environment, at least as accurate as needed, according to the standards of each scientific survey. Our research objective is to accurate localize the AUV in the three dimensional environment (3D) using its own sensors without any external infrastructure under the concept of Simultaneous Localization and Mapping (SLAM). The environment will be sensed by state of the art multibeam echosounders that they are becoming broadly available, providing high precision of the surrounding bathymetry and they are not disturbed by turbidity or lighting conditions. Moreover, attitude sensors that are commonly found in AUVs will aid on the results precision. Under probabilistic 3D raw data registration and SLAM framework, most of the AUVs navigation constraints will be removed and will allow safe and precise surveys in the challenging underwater environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Art in border practice and policy' (BORDERART).

assistant: **Innovation**

The project’s main objective is to build a framework examining how artistic practice can be applied within migration policy contexts. Addressing calls by refugees, asylum seekers and human rights organisations for more humane approaches to policy, this framework will specifically investigate how artworks made in response to the EU migration crisis can raise awareness, build understanding or disrupt usual relationships between refugees, local long-term residents, NGOs and border security personnel. Developed  within a comparative study between Greece and Tunisia, the project will reflect the impact of the EU’s current retracting and expanding borders in two key sites on either side of the Mediterranean sea. As the EU enacts ‘buffer zones’ to stem the arrival of asylum seekers on mainland Europe, art practices will be analysed for the ways in which they express and alleviate multiple stresses for those impacted by such policy.  Beginning with a review of artistic practices on site in these two locations, the project will map and analyse how art reveals relationships between multiple actors across refugee, resident, NGO and border personnel communities. This review will be contextualised by a wider review of art in global border practices. Interviews with key informants and observations of different practices in Greece and Tunisia will then inform the  development of a practice as research methodology, drawing on the ER’s own arts practice to co-create a series of artworks with local actors to test and map possibilities for new and different relationships between those enacting and those impacted by migration policy. This participatory arts practice  will iterate through a regular co-evaluation process to a build a framework that reflects the role of art in relation to mul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ultrafast photonics for the detection and recognition of toxic spine-structures of amyloid aggregates linked to neurodegenerative disease' (UPRECON), addressing dissemination and exploitation.

assistant: **Impact**

Projections indicate that, by 2050, every person aged 85 years or more will be diagnosed with a cognition-related disease. While there is currently no clear strategy for curing such diseases, there are promising developments in the early diagnosis of disease and the inhibition of worsening symptoms. Building on results obtained during my post-doctoral work regarding laser technology for amyloid aggregates detection, I propose to use an advanced ultrafast spectroscopy for structural analyses of the peptides and proteins that form the different fibril architectures in the brains of patients with pathogenic aggregates. In combination with multiphoton absorption, this laser technique has the potential to detect and diagnose in a non-invasive modality the early forms of toxic oligomeric intermediates in the brains of persons with suspected Alzheimer´s or Parkinson´s disease. This methodology has potentially enormous benefits for patients and society. Importantly, the proposed approach of using high-intensity light in the infrared region of absorption does not damage cells and tissues during long-duration irradiation, it does not require the use of chemical labels, and it reduces the need for surgical intervention, as it is non-invasive and safe for human health. I will transfer the knowledge and expertise on biophotonics of amyloid fibrils to Europe and the Host laboratory at the Polish Academy of Science will provide me with advanced training in time-resolved ultrafast laser spectroscopy and access to newly designed setups, as well as supplementary career path-specific training in ancillary skills.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Open EURAXESS – To strengthen the effectiveness and optimize the services of all partners in an innovative and open EURAXESS network'.

assistant: **Innovation**

The EURAXESS TOP IV consortium includes partners from 40 countries (34 beneficiaries and 7 Linked Third Parties), covering the whole EURAXESS network and maximizing the impact for the long-lasting benefit of the research community.The project has been divided into 8 work packages, apart from the WP devoted to Project management. WP2 (EURAXESS Career Development), WP3 (Social Integration Initiatives) and WP4 (Engagement with industry) aim to address strategic issues related to the widening of the services from mainly mobility-related to services also for non-mobile researchers. In particular, WP2 and WP3 aim to expand the set-up and operation of Career Development and Dual Career services within the network; on the other side, WP4 promotes intersectoral mobility of researchers by promoting entrepreneur careers through collaboration with innovation facilitators and launching industry-academia mentoring programmes for researchers.WP7 (EURAXESS Open to the World) aims to attract third country researchers to Europe as well as European scientific Diasporas contributing thus, to brain circulation while WP5 (Capacity Building of the EURAXESS Network), WP6 (Network support and a comprehensive communication and cooperation strategy for EURAXESS) and WP8 (Open EURAXESS portals) aim at the deepening of existing services through trainings, networking and updating of national EURAXESS portals. Based on the results of the project and the future trends in the ERA, a strategy and a vision for EURAXESS towards 2030 will be delivered within WP9 (Future of the EURAXESS Network–New services).Finally, the impacts of the project are linked to increasing the visibility of EURAXESS Network and diversifying the services provided by the EURAXESS Service Centers at an increased quality to enhance