RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Selective production of valuable chemicals by electro-nano-catalysts'.

assistant: **Objectives**

To minimise the impact of mankind on the environment while ensuring economically viable industrial activities, greener processes are needed. In particular, developing selective synthesis routes of valuable chemicals with limited waste in the production is a major challenge faced by industry.  As a case study, Haldor Topsøe, world expert in catalysis and secondment host in the project, aims to produce the valuable chemical dimethyl carbonate (DMC) without CO2 emission. Within this framework, the SELECTRON project will develop an electro-nano-catalyst for the selective and green production of DMC from methanol and CO. First, a nanotoolbox and a new synthesis route will be developed using a microwave reactor synthesis to provide Pt, Au, Ag, Cu nanocatalysts with controlled shape and structure. Second, the electrocatalytic properties of these catalysts for production of dimethyl carbonate will be assessed for the first time by state-of-the-art electrochemical and chemical characterisation but also more advanced technique like spectro-electrochemistry in parallel to theoretical simulation. Based on the knowledge gained on the electrocatalytic mechanism, a stable and selective catalyst will finally be produced. This highly interdisciplinary project will benefit from my strong background in nanomaterials design and synthesis, electrochemistry and catalysis, the complementary expertise of the host group in spectro-electro-chemistry, expertise of collaborators in theoretical simulation, and the strong commitment of Haldor Topsøe to bridge the gap academia-industry in order to develop a green production method for valuable chemicals like DMC. I will develop the required skills to become an independent expert in the emerging field of green production of valuable chemicals by elect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The extracellular matrix as a mediator of cell-cell communication in cardiovascular inflammation'.

assistant: **Concept**

Cardiovascular diseases, as coronary artery disease (CAD) and its sequelae myocardial infarction (MI) and heart failure, represent the leading cause of morbidity and mortality in industrialized and developing countries. Atherosclerosis is the pathology causing CAD and MI; both are characterized by a sterile inflammation with a chronic and acute course of the disease, respectively. There is a plethora of cell types, as leukocytes, endothelial cells, vascular smooth muscle cells, platelets, fibroblasts, and cardiomyocytes, which play important roles in the initiation, propagation, and termination of the pathophysiological processes. Recent data from genetic studies found that genetic variation influencing extracellular matrix (ECM) proteins is associated with cardiovascular diseases. We found that such proteins which are secreted by one cell type influence phenotypes of other cell types via, e.g., silencing of inflammatory functions or modulation of ECM composition. The ECM hence not only represents a meshwork in which cells are organized but also a communication hub to transduce mechanical stimuli and cell-cell-interaction signals. Here, we aim to explore the ECM proteome in sterile inflammatory diseases as atherosclerosis and MI in an unprecedented depth. We aim to identify novel regulators which give insights into the underlying processes and we will study the molecular and cellular mechanisms modifying the course of the disease. This will lead to the identification of novel therapeutic targets which might reshape our understanding of how these diseases occur and how we can prevent them, and to the development of novel, individualized treatment strategies. Finally, we aim to translate our findings to humans to get first insights on whether these strategies can be adapt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Study of tau strains to understand the phenotypic diversity of Alzheimer’s disease: A step toward personalized therapies' to be submitted under Horizon 2020.

assistant: **Abstract**

Dementia represents a major challenge for our ageing societies. The number of citizens suffering from dementia in the EU is expected to reach 19 millions by 2050. Alzheimer’s disease (AD) is responsible for the vast majority of dementia cases. However there is still not a single available treatment that modifies the course of disease. Therefore, the development of innovative approaches to better understand the pathophysiology and ultimately treat patients must be a priority. This project aims to understand the determinants of the diversity of AD clinical phenotypes through the deep analysis of pathological variants of the tau protein. As the accumulation of Aβ peptide has long been considered a causative event in AD, most therapeutic approaches have targeted Aβ metabolism, but unsuccessfully. Modern biomarkers, have confirmed that the brain deposition of tau pathology, the other hallmark of AD, correlates much better with human cognition and neurodegeneration. Recently, it was shown that tau behaves like a prion and can spread from one neuron to another. Moreover, tau strains or conformers seem to template native tau and propagate the pathological conformation with high fidelity. Discrete tau strains generate distinct aggregates morphology or patterns of neuronal vulnerability. I postulate that different strains of tau are responsible for the variability of AD and may determine the progression rate, gender differences or clinical expression. Therefore, my objective is to develop the technologies to identify tau strains signatures in distinct AD phenotypes. In particular, I plan to develop and optimize biosensor cell lines that sensitively detect tau strains from human brain samples and cerebrospinal fluid, and characterize respective repertoire of tau strains. Understan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An intracellular approach to spatial coding in the hippocampus' to be submitted under Seventh Framework.

assistant: **Abstract**

The hippocampus is an important structure for spatial memory in rodents and episodic memory in humans. The hippocampus uses a sparse coding scheme where a given environment is represented by the place selective firing of a small group of cells, (called place cells) among a larger population of silent neurons. Thus a given environment is not only coded by the firing rate and timing of active cells but also by the very identity of these cells that fire or stay silent in that environment. Similarly, in humans, specific items or episodes are coded by the selective firing of particular cells in the temporal lobe among a larger population of silent neurons. Thus understanding the mechanisms involved in the selection of which cells will be active in a particular environment is one of the most important to understand the formation of spatial memories in rodents and episodic memories in humans. This question is at the core of our research project. Place cells have been extensively studied at the system level using extracellular recording which can only record the spiking output of neurons but not the intracellular mechanisms leading to that spiking. This is why I recently contributed to the development of a new technique allowing intracellular recordings in freely behaving animals. Using this technique we found an important role for intrinsic neuronal properties in the distinction between place and silent cells. Intriguingly, these differences were observed even before the new exploration began. Based on these findings we will address three objectives: 1) determine the role of intrinsic excitability in the initial selection of place cells, 2) test whether a similar coding scheme are valid for the other major hippocampal area for spatial coding: the CA3 area and last 3) determine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Translating Research into Practice - TRIP to Researchers' Night 2008' (2007-2013).

assistant: **Concept**

The objective of the Researchers’ Night 2008 event in Eastern Finland on 26th of September is to bridge the gap between city and science, to allow casual face-to-face meetings between citizens and researchers in a relaxed atmosphere as a joint undertaking of two regions, five research and development organisations and several associated organisations. The activities of the Researchers’ Night 2008 Eastern Finland will be organised simultaneously in two regions, in cities of Kuopio and Joensuu with their surroundings.   The activities to be arranged, like science cafés, photos and drawing competitions, games and radio shows, give large public an opportunity to meet researchers from a wide range of scientific fields in an enjoyable environment and a variety of entertaining and fun activities will aim to highlight the appeal of pursuing a career in research. To introduce the international character of research international guests, researchers and students will be invited to take part to a number of activities. The event seeks to enable new thematic perspectives by bringing researchers, cities, schools, associations and companies together in order to show how research translates into practice in a concrete way. The event increases citizens’ knowledge about the diversified research carried out in the universities of Eastern Finland and embraces the universities’ consolidation and creation of the University of Eastern Finland in 2010. Public at large will learn about the impact research has on the regions and on larger scale to Europe’s competitiveness and sustainability.   Both of the regional events follow the same variety and structure of activities, but their themes and topics differ based on regional tendencies and strengths. The themes will highlight the know-how, exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Physbio'.

assistant: **Concept**

Our objective is to combine a training activity (EuroSummerSchool) and a research activity (EuroWorkshop) in order to provide a new model for the intensive training of Young Researchers (EuroTrainingSession") and improving the collaboration between researchers within Europe, in the field of nonlinear science and complexity. The topics presented in the present proposal include: 2002: Biomechanics: from Molecules to Morphogenesis aiming at establishing a dynamical bridge connecting structure to function in molecular and cellular biology. Examples are the mechanics of ion channels and molecular motors, the physics of supercoiling and condensation in DNA, the mechanics and dynamics of self assembly and polymorphism in proteins. the rheology of the cytoskeleton, active cell spreading, adhesion, aggregation and migration, and mechano-transduction. 2003: From Pattern Formation to Granular Physics and Soft Condensed Matterfi where continuum descriptions of the type introduced in particular in pattern formation will be used to treat complex materials in particular out of equilibrium, including those with an intrinsically discrete structure like granular flows and foams, but also liquid films and interfaces.One aim is to understand the principles of self-assembly and possibly the formulation of new unifying principles governing the non-equilibrium world. Future sessions will be devoted to topics in fluids and turbulence, in non-linear optics, geomorphological and ecological patterns, waves and fronts in chemical and biological systems, instabilities in quantum condensates, topics in soft matter physics, etc."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Improving adoptive T cell transfer immunotherapy for cancer with T memory stem cells'.

assistant: **Concept**

Here we seek to identify the genetic program at the basis of T memory stem cell persistence in vivo and use their properties to improve the adoptive T cell transfer for the treatment of human cancer. Adoptive cell transfer with tumour-specific T lymphocytes is currently under test in the clinic for the treatment of solid tumours such as melanoma. However, the poor persistence in vivo of adoptively-transferred cells is the major caveat to successful immunotherapy. Recent evidence suggests that CD8+ T cells derived from lymphocytes at early stages of differentiation better mediate tumour rejection due to their increased persistence, survival and proliferation in vivo. We recently identified the least differentiated human memory T cell subset, the T stem cell memory (TSCM), capable to self-renew and simultaneously generate more differentiated progeny. These TSCM are also endowed with superior immune reconstitution capacity and anti-tumor immunity (Gattinoni L, Lugli E et al. Nat Med, 2011;17:1290-97). However, the genetic program at the basis of persistence of these cells, especially under chronic stress, still needs to be defined. By studying immune reconstitution in haploidentical, T-repleted bone marrow transplantation, we will address this question and subsequently exploit this information to improve anti-tumor immunotherapy. Specifically, we will:1.Determine whether TSCM cells are major contributors to the process of immune reconstitution as suggested by non-human primate and humanized mouse models.2.Identify the genetic program responsible for the persistence of TSCM cells in vivo under conditions of continuous stress, i.e. the lymphopenia induced by the conditioning regimen3.Genetically-modify tumor-specific T cells with candidate genes to improve persistence in hum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unraveling the etiology of congenital heart defects – The role of maternal genetics and cardiovascular disease as a risk factor' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

One in a hundred infants is born with a congenital heart defect (CHD). Both genetic and environmental risk factors, such as maternal diabetes and obesity, are known to cause CHD, however, little is known about the disease mechanisms behind these risks. CHD can occur as an element of a syndrome, in conjunction with other anomalies, or as an isolated defect. I propose that there is an etiologically distinct environmental CHD subgroup, where in addition to the childs genes, maternal genetics and gene expression play a major role in disease development. Moreover, I propose that in these cases the genetic risk profile predisposes the woman for both having offspring with CHD and having early onset atherosclerotic disease. My objective is to study how maternal genetics and maternal cardiovascular morbidity as an environmental risk contribute to the risk for having offspring with CHD. In addition, the multifactorial aetiology in terms of the presence of both risk factors, will be studied using a unique dataset available only in Finland. Three different substudies will be conducted: 1) Finnish national registers gathering health related information of all Finns from birth to death will be used to determine the presence of atherosclerosis and related traits, such as hypertension and coronary artery disease, in mothers who have offspring with CHD compared to those without (tot. N = 1 million). 2) Maternal genetic risk loci for having CHD in the offspring will be sought in the FinnGen study (tot. N = 0.5 million). 3) Maternal 1st trimester serum samples from pregnancies with and without CHD will be analysed to identify CHD associated biomarkers (tot. N = 3200).The study results will provide important information on how the combination of maternal genetic and environmental risk fact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Women at work: for a comparative history of African female urban professions (Soudn, Tanzania and Ghana), 1919-1970' (WomatWork).

assistant: **Concept**

WomAtWork represents the first comparative investigation into the history of female urban popular professions in three African countries – Ghana/Gold Coast, Sudan, and Tanganyika/Tanzania – over the course of fifty years (1919-1970). Not only is this topic under-studied in African history, but these professions (i.e. midwives, beauticians, wedding singers, market vendors, craftswomen) are also characterised by fascinating and unsettling aspects. For example, notions such as a set price for a service and fixed working times or workplace did not apply to many of them. WomAtWork aims first to discover the peculiarities of these labour patterns and see their historical transformations as a result of political changes and the introduction of new technologies and commodities. Secondly, it examines professional subjectivities, the work ethos, norms and values of women at work. Finally, it questions the relationship between these professionals and their communities – including in the light of the social stigma sometimes attached to them – as well as the nexus between these labourers and protest, charting when and why they laid down their tools. Based on an innovative methodology, this project seeks to overcome the invisibility of women in official archives by weaving together different threads of sources. It begins inside those photographic archives connected with institutions that had conscious agendas of representation and routines of intense textual production (for example, missionary stations). In some cases, these visual and textual sources lead to networks or families of women professionals, whose oral history will be solicited. Third, the project aims to analyse the vernacular press combined with oral accounts.Through these objectives and methodologies, WomAtWork will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'LIVING TOGETHER: AN INTEGRATED ACCULTURATION-CONTACT STRATEGY TO PROMOTE ETHNIC HARMONY BETWEEN BRITISH MUSLIMS AND ANGLO-BRITONS' (ICAPEH) under Horizon 2020.

assistant: **Objectives**

The proposed research project integrates acculturation theory and the contact hypothesis to form a new strategy to promote positive intergroup relations among British Muslims and Anglo-Britons. This project will be the first of its kind and a timely one, considering the escalating ethnic tensions between the two groups. The primary aims of this research project are to:i) gather much-needed and current baseline British data on the acculturation orientation, level of contact, and intergroup attitudes among high school Muslim and Anglo British students;ii) develop, implement an experimental design, and longitudinally evaluate an acculturation-contact strategy to promote intergroup harmony between high school Muslim and Anglo British students; iii) empirically determine whether the extent of the acculturation-contact strategy effects on intergroup relationships vary by group status (Muslims vs. Britons) and gender; andiv) empirically identify and contrast possible mediators of the acculturation-contact strategy effects on intergroup relationships to understand the mechanism through which the strategy works.The novelty of this timely project lies in its careful integration of a strong acculturation-contact conceptual framework and the adoption of a strong longitudinal experimental design to promote British Muslims and Anglo-Britons’ harmony. This project will achieve this goal by (1) integrating two leading conceptual frameworks, Acculturation Theory and the Contact Hypothesis, that have not been put together conceptually and empirically so far; (2) implementing vital recommendations made for the best practice framework for the conduct of contact research; (3) introducing e-technology to strengthen students' Integrationist endorsement; and (4) providing applied cultural psyc