RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Agenda for Research on Tourism by Integration of Strategies for Transport' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The objectives of the proposed project are to address the issues of Task 12.6 of the Transport RTD Programme (Study on Impact of Tourism on Transport and Analysis of Policy Relevant Implications), i.e. :(i) to analyse the share and dynamics of tourism in total mobility;(ii) to review existing visitor management practices, especially in European cities with large tourism flows, and(iii) to demonstrate the need for a Community transport initiative on this issue. Demographic and socio-economic factors, as well as changes in business practices, will be taken into account for the purposes of the analysis. On the basis of the research findings, recommendations will be made on ways of combining statistics on tourism with those on mobility for transport purposes.The principles and practices of visitor management of large, or unusual visitor flows will be analysed for a number of selected (sub)urban areas. These case studies will help identify opportunities of improving access to tourist attractions by other modes of transport than the private car. This will include the role of all local players i.e. transport operators (whether public or private), local authorities and the tourism industry, including tour operators, travel agents, hotels and reservation systems.The main justification for this project is that the overall research will demonstrate how tourism statistics can be applied to related transport mobility, as well as providing lessons for urban and transport planners in managing tourism flows. Integration of the data analysis with the best visitor management practices will lead to recommendations on the need for a Community transport initiative on visitor management, including a comprehensive research agenda, demonstration activities and recommendations for land-use plan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Maternal Enteric Microbiota for Offspring's Repertoire development and Illness Susceptibility', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Recently, it has emerged that early life exposure to commensal microbes is crucial to instruct our immune system and prevent later life autoimmune and metabolic diseases. The host lab now showed that this education begins even earlier – during gestation by signals from the maternal intestinal microbiota. Using the E. coli strain HA 107, genetically engineered to grow in vitro without the ability to persist in vivo, they demonstrated that transient intestinal colonisation of pregnant germ-free mouse dams drives neonatal innate immune maturation. However, the long-term consequences of maternal microbiota cues especially for the adaptive immune system of the adult offspring remain elusive.The MEMORIS project (Maternal Enteric Microbiota for Offspring's Repertoire development & Illness Susceptibility) shall elucidate the long-term consequences of maternal microbial signals for the offspring’s adaptive immune system and disease susceptibility. My specific aims are to reveal the consequences of gestational colonisation for the offspring’s (1) own intestinal microbiota composition and metabolism; (2) adaptive immune repertoire development; and (3) susceptibility to autoimmune and metabolic diseases. For this, I will colonise offspring of gestationally colonised versus germ-free mouse dams at birth and by (1) metagenomic, metatranscriptomic and metabolomic read-outs assess its dynamic microbiota development. (2) Flow cytometric and transcriptional profiling, immunglobulin gene sequencing and bacterial FACS will reveal adaptive immune repertoire maturation. Based on these results I will (3) elucidate the role of maternal microbiota signals for disease susceptibility using NOD mice modeling type 1 diabetes and high fat diet-induced non-alcoholic fatty liver disease.I would like t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Practical oxyfunctionalisation biocatalysts by engineering monooxygenases into peroxyzymes.'.

assistant: **Innovation**

Chemistry is far away from being a mature science: many desirable transformations are still out of scope. One important example is the selective (oxy)functionalisation of non-activated C-H bonds, which still represents a dream reaction of organic chemistry. This is because balancing high reactivity (needed for the activation of inert C-H bonds) with selectivity is difficult to achieve. Enzymes, specifically monooxygenases, are catalysts that principally solve this challenge.Monooxygenases, however, are not practical catalysts for organic chemistry. This is because they have evolved to enable the survival of their host organisms and not to suit the needs of organic chemists. In particular the complex molecular architecture of monooxygenases (necessitating O2, stoichiometric reductants and additional catalytic components) together with mechanistic challenges arising from their complex molecular architecture impede their chemistry-wide application.PeroxyZyme aims at solving these issues and establish evolved monooxygenases (peroxyzymes) as practical catalysts for organic chemistry. Peroxyzymes will be able to function with simple hydrogen peroxide rather than via the natural, albeit complex and vulnerable electron transport chains. This fundamental change in the monooxygenases catalytic mechanisms will be achieved by a mechanism-driven and experimentally validated semi-rational engineering approach. Evolved peroxyzymes will be characterised using up-to date (ultra)fast spectroscopy identifying catalytic bottlenecks and possible inactivation mechanisms. This molecular understanding will provide the basis for further improvement of first generation peroxyzymes. The practical usefulness of evolved peroxyzymes will be demonstrated on preparative-scale by using them in non-aque
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Applied stochastic models for ocean engineering, climate and safe transportation' under Sixth Framework.

assistant: **Concept**

The network shall bring together probabilists/statisticians, researchers in the marine and meteorological fields, and maritime safety enterprise on wave climate, information and databases, and the safety of marine transports, offshore and coastal installations.Much of the research in the area has been highly fragmented. There are few statisticians working actively with the very intricate problems arising in maritime safety, and naval engineering does not influence statistics research in a way that, for example, control engineering of life science research has done.The idea behind the network is to bring together the best possible knowledge and research potential in the different fields in order to:I) improve information extraction from marine data,II) va lidate non-linear wave models from spectral properties,III) improve extreme value analysis for climate and sea data,IV) improve computational tools for wave analysis and route simulation,V) get better understanding of near-shore waves and hazards for coastal installations,VI) improve technique to determine stricter safety limits in marine design, regulation and operation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploiting the DNA damage response to induce degradation of proteins' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Here I propose to use small molecules to degrade proteins specifically around sites of DNA damage by using the damage itself as a homing signal. The approach will create new ways to study DNA damage, but will also offer translational possibilities in cancer. Cancer cells are often acutely sensitive to DNA damage because they have one or more faulty DNA damage response (DDR) pathways – a feature that makes them highly dependent on their remaining DNA repair systems. We will pioneer two novel and related chemical approaches for selectively killing cancer cells by modulating DDR pathways with bifunctional DNA damaging molecules. We will do this by reprogramming E3 ligases. E3 ligases are modular multi-protein complexes that destabilize cellular proteins by catalysing the formation of polyubiquitin chains on its substrates, which serve as a signal for proteasomal degradation. A recent revolutionary advance in chemical biology is to use small molecules to reprogram the protein degradation specificity of E3 ligases. By degrading proteins instead of inhibiting them, these small molecules achieve levels of functional modulation typically only possible with genetic techniques. We are inspired by this new protein degradation technology, but will take it in a new direction. Chemical damage of DNA recruits E3 ligases as well as critical DDR proteins in preparation for DNA repair. We will invent a new generation of small molecule protein degradation catalysts by repurposing these natural responses to DNA damage.We will accomplish our goal with three aims:Aim 1: Use DNA damage as a homing signal for induced protein degradationAim 2: Use direct repair of DNA damage by the repair protein MGMT to promote the degradation of other proteinsAim 3: Promote pleiotropic protein degradation by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Cold forging and blanking tool manufacture for optimal coating perfomance'.

assistant: **Innovation**

Tooling plays a central role in the metal forming industry. Not only does its manufacture account for significant costs but its failure can lead to high costs when part quality suffers and machine down-time is high. In addition, the friction at the tool / part interface requires the use of costly and environmentally unfriendly lubricants which also often results in unhealthy working environment conditions. The need to reduce the production costs related to tooling is recognised by this group of SMEs as critical to maintaining competitiveness. Hard coatings are known to improve the tool performance and lower tool-related costs. This can be seen in the results of countless research projects and industrial case studies. The question is: If coated tools are so good, why doesn't every metal forming company use them where they have the potential to help? The truth is that many companies, especially SMEs, have tried coatings, and because of poor initial results, have never used them again for that particular process, or worse yet, have completely given up on the use of coatings. The reason for the failure is that companies often attempt to coat previously uncoated tools without changing their manufacturing process and surface finishing, producing poor results. The savings potential from the application of the proper coating with the proper tool manufacture is recognised by this consortium as being great, not only for the consortium members, but for the metal forming industry as a whole, a great number of vvhich are SMEs. This project will identify the relationship between the tool manufacture and the performance of a subsequent coating. This will be done by closely examining the tool manufacture parameters combined with an analysis of the metal forming and blanking processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A thematic network for Standards, Measurements, Testing and research in Environmental Instrumentaion and Monitoring' (STREAM) under Fourth Framework.

assistant: **Objectives**

The overall objective of the STREAM network is: 'to bring together environmental regulators, researchers, manufacturers and users of water quality and water quantity instrumentation to increase industrial competitiveness, improve standardisation and to promote better exploitation of new science and technology.' At present, there are no existing networks which will achieve this, and provide the benefits described below. The proposal made to the European Commission is to explore the feasibility of establishing a thematic network of organisations using, researching and manufacturing instrumentation for monitoring water quality and quantity. The principal stages will involve consulting the major users, researchers, manufacturers, and environmental regulators involved in this field. Contact will be made with the European Environment Agency to ensure that the aims of the network compliment their current work programme. Existing networks such as TechWaRe and Euraqua will provide useful starting points for identification of those organisations which may have a key role to play in the eventual STREAM Network. Should the exploratory phase demonstrate that such a network is feasible, the following benefits may accrue from the full STREAM Network: - researchers will be aware of end-users needs; - end-users will be aware of what science can deliver; - manufacturers will be aware of gaps in the current market; and - where RTD is not currently underway, proposals can be submitted to the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples.' (GIFTS) targeting Seventh Framework.

assistant: **Abstract**

Despite a strong genetic component to diabetes and obesity, the rapidly rising prevalence of these disorders is due to adaptation to a changing environment. The epicentre of the ‘diabetes epidemic’ is in South Asia and this is reflected in the migrant populations in Europe. Current prevention strategies are focused on adult life and target over-nutrition in high-risk adults. However, for many population groups across the globe, these strategies ignore many key principles that underlie the increasing global prevalence of these diseases.  A substantial portion of the South Asian people, living in their home countries experience nutrition deprivation, while after migration to Europe, may encounter nutritional abundance resulting in imbalance during their lifecourse. These conditions are of particular importance during foetal and early developmental stages where environmental insults may interact with genetic risk to induce ‘foetal programming’ of adult metabolic disease. Few groups have targeted early life programming as an opportunity for the prevention of diabetes/obesity in childhood and subsequent adult life and there are limited guidelines on this topic. The proposed grant will bring together a unique group of investigators in South Asia (India, Bangladesh and Pakistan) and Europe (UK, Norway, Germany and Finland) with SMEs of complementary expertise (Germany and Spain) combining prevention strategies, state-of-the-art genomics, social sciences and public health that focus on these early life predictors of disease. The major objective behind this collaborative and multi-disciplinary approach is to combine knowledge from the work packages on lifestyle, nutrition and genomics to both inform public health policy through guideline development and design a large-scale prag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Divided Metacognition: when epistemic norms conflict'.

assistant: **Innovation**

The present project aims to provide a naturalistic account of epistemic norms, and of the associated epistemic awareness in  children and adults from different cultures. Epistemics norms (ENs) such as intelligibility, relevance, truth, coherence and consensus are dimensions on which mental contents can be evaluated for their contribution to knowledge acquisition. Although EN sensitivity is central in education, little is known about 1) how to systematically analyze and inventory ENs, nor about  2) How and to what extent, children and adults from different cultures and socioeconomic backgrounds recognize them in making epistemic decisions. Specialists in philosophy of mind, developmental and adult congitive science, along with field anthropology, will apply their methods to address these questions in an interdisciplinary spirit. A common methodological guideline will be to study EN sensitivity as embedded in self-evaluative judgments, and to focus on cases of conflict between various ENs, such as consensus versus truth. This research should reveal how EN sensitivity develops in European and Japanese children, what role is to be assigned, in norm dominance, to emotional interaction, epistemic or social deference, and how EN sensitivity is transferred, in similar tasks and contexts, from self to others and reciprocally.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'microRNA biomarkers in an innovative biophotonic sensor kit for high-specific diagnosis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Since 2001’s discovery of microRNAs (miRNAs) in humans, progress in genomics and transcriptomics has increased our comprehension of gene expression regulation. miRNAs are small, noncoding RNA molecules showing huge promise as clinical biomarkers and diagnostic tools for illness and disease, as significant changes in their expression occur in response to pathological states. However, miRNA detection is still challenging nowadays, since costly, complex sample preparations and RNA amplifications are not yet reliable enough for clinical decision making. In this context, three innovative EU companies, Optoi Microelectronics - with microelectronic knowhow and manufacturing skills - DestiNA Genomics - with ‘error free’ chemical technology for microRNAs recognition – and GeneXplain – with bioinformatic capabilities - joined forces with four key academic research groups from the Universities of Trento (Italy), Granada (Spain), Hannover Medical School (Germany) and Santa Catarina (Brazil). All the parties combined their knowledge with respect to miRNA biomarkers with a particular focus on lung cancer, to develop a novel and reliable miRNA detection system for this disease. To this end, research collaborations will address the analysis of miRNAs specifically over-expressed in lung cancer, continuing experimental work already started in the past years, but with greater integration and focus.Existing close partnerships with healthcare institutions will be strengthened, ensuring multi-site and multi-ethnic sampling. In parallel, optimization and validation of a miRNA detection kit based on Optoi semiconductor optical detector will continue. The DestiNA patented technology for specific nucleic acid recognition will be refined to reach the integration and result reliability required fo