RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'IMPROVEMENT OF OVERALL FOOD QUALITY BY APPLICATION OF OSMOTIC TREATMENTS IN CONVENTIONAL AND NEW PROCESSES' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research on the application of osmotic dehydration to food processes is on-going at numerous laboratories all throughout Europe. The interest is due to the possibility of modifying the functional properties of the food material and improvement of the overall quality of the products together with the potential energy saving by application of an osmotic step in conventional food processes. Despite the great efforts made, essential problems remain to be solved. The development of this field can be achieved only by co-ordinated research with integrated objectives and efficient exchange of the acquired knowledge, by means of a concerted activity.The most important task of the proposal is therefore to create and improve the linksbetween the different groups working on osmotic dehydration in order to acquire thenecessary knowledge to optimise the food quality with special attention to the nutritional and sensory quality and to control the osmotic dehydration from the engineering point of view. This will be met by:- Collect and amalgamate the necessary scientific knowledge in order to use the osmotic dehydration as a pre-treatment for food processing (combined processes) by:- evaluation and control the modifications achieved in the food material (composition, structural, functional properties, etc.) in order to improve the overall quality of products obtained by freezing, chilling, convective drying and other conventional and new food processes.- determination of possible undesired changes in food materials occurring during the osmotic process (structural, diffusion of components, oxidative or deteriorative reactions).- study of the interactions between solutes and the food components in order to use different solutes and solute blends to achieve the desired quality properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'sociogeNEsis of criMinal nEtworks: reconStruction, dIscovery and diSruption' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Europol defines criminal networks as a modern version of the Hydra mythological creature, with obscure genesis, fluid structure and multifaceted evolutions. Leveraging a unique synergy between Social Sciences and Statistics, NEMESIS departs from current practice to translate the main obstacles (i.e., data incompleteness and complexity) underlying the reconstruction, discovery and disruption of these modern criminal networks into a unique resource for crucially expanding available knowledge and policies. This ambitious perspective builds on three somewhat overlooked, yet fundamental, observations. First, data missingness in criminal networks can be, in fact, a fundamental source of information on the structure and secrecy strategies of organized crime, and, as such, should be embraced and not disregarded for network reconstruction. Second, the complexity and multiplexity of covert and overt interactions among criminals may hide a wealth of yet unexplored knowledge on the formation, mutation and sociogenesis of criminal networks, hence invaluable for their discovery. Third, “cutting” Hydra heads without realistic predictions of the corresponding re-generation processes undermines not only the development of innovative law-enforcement disruption strategies, but also the identification of more nuanced high-value targets. NEMESIS transforms these perspectives into rigorous, interpretable and practically-impactful generative statistical models of criminal networks and introduces innovative concepts of secret criminal species, covert networking activity codes and dark evolutionary trees. This perspective is expected to revolutionize current practice of conceptualizing, reconstructing, analyzing and disrupting criminal networks, while opening new avenues for the creation of fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Structure-Based PROTAC Design In-Silico'.

assistant: **Concept**

Proteolysis Targeting Chimeras (PROTACs) are small molecules that induce the degradation of target proteins of interest and have shown considerable promise as novel therapeutic agents.  PROTACs are heterobifunctional compounds containing one moiety that binds to the target protein of interest and one that binds to an E3 ubiquitin ligase. Recruitment of the E3 ligase leads to ubiquitination and subsequent degradation of the target by the proteasome. The design of PROTACs largely remains an empirical process because of an insufficient understanding of the molecular basis for productive recruitment of target and E3 ligase into a ternary complex. Furthermore, there are only a handful of small-molecule ligands for E3 ligases that are amenable for PROTAC conjugation, so expanding the chemical space to PROTAC design is an important direction for the field. Virtual screening and structure-based drug design are powerful approaches for designing of drug-like molecules but their application to PROTAC design is still in its infancy. The structural complexity of the ternary complex central to PROTAC activity, and the chemical complexity of PROTAC molecules, are amongst some of the main challenges to structure-based PROTAC design. The goal of this proposal is to develop novel methodologies to contribute to systematically address these important challenges. The long-term goal of this proposal is to develop structure-based PROTAC design as an efficient, universally applicable platform for prediction, designing, and screening of effective PROTAC degraders of target proteins. The success in this project will pave the way to efficiently degrading “undruggable” targets as a powerful new modality of chemical intervention into biology and disease.


**Keywords:** Proteolysis Targeting Chimer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The shadow of migrants’ social networks: Towards a new theory of how social networks can increase migrants’ economic vulnerability' (SHADOW).

assistant: **Innovation**

SHADOW develops a new sociological theoretical framework, studying how social networks impact migrants’ economic vulnerability by creating social welfare deficits. In sociology, social networks have been assumed to improve migrants’ economic position by providing financial, informational, and instrumental support. Yet, evidence from other disciplines shows that they can also be harmful by serving as gatekeepers to labour markets or by providing misinformation. SHADOW addresses this gap in sociological understanding.SHADOW integrates theories from sociology, social psychology, and political science, introducing a novel multi-level, multi-group theory about why and how social networks can increase migrants’ economic vulnerability. First, it will use administrative data to identify and map the networks linked to migrants’ economic vulnerability. Second, it will examine how social networks increase vulnerability, testing a new theory of social welfare deficits - liabilities and constraints imposed by social networks- like pressure, misinformation, or stigma. Third, it will study migrants’ reactions to these social welfare deficits, such as distancing from harmful networks. Last, it will look at how welfare states impact these deficits and migrants’ economic vulnerability. SHADOW will compare four migrant groups residing in Europe with vastly different migration backgrounds and network structures.SHADOW will use a mixed-method approach, including administrative, survey, qualitative, and experimental data. It will advance the field of migration studies and generate a breakthrough in the sociological approach to social capital by including its negative impacts. SHADOW will also help policy-makers and stakeholders to design better policy interventions targeted at improving migr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High-Q semiconductor Nanostructures for single Photon emission, detection and manipulation' in the context of a Sixth Framework call.

assistant: **Objectives**

Single photon emission, detection and manipulation will be explored on the basis of a novel semiconductor technology platform. By using semiconductor nanostructures like quantum dots, high-Q microcavity pillars or high-Q photonic crystal cavities, the interaction of individual photons with quantised electronic systems can be strongly enhanced to allow a full control of the light generation, detection and manipulation at the single photon level. Within the framework of the project major building blocks of future single photon systems will be developed and explored.Leading European research laboratories from universities, public research institutes and the industry with expertise in nanostructure technology, optoelectronic devices and quantum physics will work together. The project is expected to have a large impact on different areas of optical data communication (e.g. quantum cryptography) and on-chip data processing (like highly integrated single photon circuits). Several key devices, such as single photon emitters, single photon detectors as well as optical buffers, will be demonstrated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Immunophotodynamic therapy of cancer: concepts and applications'.

assistant: **Objectives**

Photodynamic therapy of cancer, i.e. the generation of reactive oxygen species in the tumour environment which follows the irradiation of suitable photosensitising molecules, is an attractive modality for the selective ablation of inoperable superficial neoplastic lesions, such as certain head and neck, gastrointestinal, urogenital and gynecological tumours. It is likely that the scope and efficacy of photodynamic therapy could be enhanced by: - the availability of novel efficient photosensitizers which absorb at in the red / near infrared region of the spectrum, where light penetration of tissues is maximal - the use of antibody-photosensitizer conjugates or conceptually related innovative delivery systems, which concentrate the photosensitising molecules at suitable neoplastic sites.The tumour neo-vasculature appears to be an attractive target, since the selective delivery of photosensitizers may occlude the tumour blood vessels, thus causing an avalanche of tumour cell deaths. In this Project, we have put together a network of academic research groups and companies, for the development of antibody-based targeted photodynamic therapy modalities. The planned research activity starts with the synthesis of novel photosensitising molecules suitable for conjugation to antibodies, and with the identification of novel human monoclonal antibodies, capable of a selective targeting of the tumour neovasculature for immuno-PDT applications.Following an extensive in vitro characterization of the most promising antibody-photosensitizer conjugates (including an innovative delivery concept in which photosensitizers are non-covalently bound to the antibody), the therapeutic potential of the best conjugates will be tested in rodent models of cancer, paving the way to future clinical ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design, manufacturing and control of INterfaces in THERMally conductive polymer nanocomposites' (INTHERM) targeting Horizon 2020.

assistant: **Abstract**

This proposal addresses the design, manufacturing and control of interfaces in thermally conductive polymer/graphene nanocomposites. In particular, the strong reduction of thermal resistance associated to the contacts between conductive particles in a percolating network throughout the polymer matrix is targeted, to overcome the present bottleneck for heat transfer in nanocomposites.The project includes the investigation of novel chemical modifications of nanoparticles to behave as thermal bridges between adjacent particles, advanced characterization methods for particle/particle interfaces and controlled processing methods for the preparations of nanocomposites with superior thermal conductivity.The results of this project will contribute to the fundamental understanding of heat transfer in complex solids, while success in mastering interfacial properties would open the way to a new generation of advanced materials coupling high thermal conductivity with low density, ease of processing, toughness and corrosion resistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Why do individuals cooperate? Exploring the behavioural, cognitive, and hormonal mechanisms governing cooperation in macaques.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

A myriad of species including humans are social. Maintenance of sociality is based on cooperative interactions among individuals. Regardless of theories and empirical explanations, experimental evidence scarcity has rendered addressing the evolution of cooperation challenging. Ergo, little is known about what influences humans and other animals to cooperate and select specific partners during cooperative interactions. Proximate mechanisms facilitating cooperation can provide crucial information on its evolution and maintenance. In this project, I will focus on the following proxies - personality, prosociality, dominance rank-relationships, and the interplay of hormones - to understand how cooperation evolved, using ~100 individuals belonging to 5 macaque species (Macaca mulatta, M. fuscata, M. fasicularis, M. sylvanus, and M. silenus). I will examine - how similarities in personality and dominance-rank relationships influence partner choice; whether prosocial motivations of individuals initiate and enhance cooperative interaction; and the effect of the interplay of peripheral oxytocin, testosterone, and cortisol on cooperation. The innovative and new perspectives of the project include– a. avoiding anonymous/forced dyad testing - testing of macaques based on their intrinsic motivations to cooperate, thus, prioritising areas of ecological relevance such as partner choice; b. testing macaques in their social groups; c. testing in semi free-ranging environment. Hence, I will use an integrative, interdisciplinary, and comparative approach in the project. My existing expertise in social cognition and subsequent training during the fellowship will undoubtedly result in pioneering research output and scientific advancement in the area of cooperation dynamics. This project is t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'NUTRITIONAL STUDIES ON DRIED FUNCTIONAL INGREDIENTS CONTAINING N-3 POLYUNSATURATED FATTY ACIDS'.

assistant: **Objectives**

Role of diet in diseases and disorders : Use of dose response studies to define the lowest level of intake of n-3 PUFA which exert a positive nutritional effect against biomakers of chronic diseases in humans. These biomarkers include the lowering of plasma triaglycerol, reducing cytokine production and the thrombotic tendancy of blood.Functional foods : Design a range of microencapsulated n-3 PUFA functionalingredients with high levels of n-3 PUFA which can be used in a wide range of end products and for a wide range of specific consumer groups.Nutritional adequacy & bioavailability : Optimise the bioavailability/oxidative stability balance by cooperative effort between process technology development and nutritional bioavailability studies. The technologies evaluated shall include antioxidant stabilisation and microencapsulation.Tasks : The main tasks involved shall include the following : dose reponse study; sourcing & stabilisation of fish oil; development and use of novel analytical techniques; process development; shelf life optimisation studies; n-3 PUFA bioavailability studies; applications development - explore a number of possible end end use products; the project should be completed in 3 years.The team : This project is led by a successful Irish Dairy Company who have recently launched a n-3 PUFA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sensitivity analysis of the impact of geological uncertainties on production forecasting in clastic hydrocarbon reservoirs (SAIGUP)' under Fifth Framework.

assistant: **Concept**

Objectives and problems to be solved: The principal purposes of the project are: - to quantify objectively the sensitivity of geological uncertainty on production forecasts, as a function of generic aspects of both the sediment logical architecture and faulted structure of classic hydrocarbon reservoirs, - to validate these results using real-case reservoir and production data. Because of the case-specific nature of existing production forecasting sensitivity studies, links between geological and production uncertainty cannot be made at present. These links are a prerequisite for early recognition of the most significant geological parameters influencing production-forecasting uncertainty and are a necessary basis for establishing optimal methods for including geological uncertainty in reservoir modelling studies. Description of the work: The project is a systematic assessment of uncertainty in reserves and production estimates within an objectively defined geological parameterisation encompassing the majority of European classic oil reservoirs. A broad suite of shallow marine sediment logical reservoir types are indexed to continuously varying 3D anisotropy and heterogeneity levels. Structural complexity ranges from unsalted to compartmentalize, and fault types from Tran missive to sealing. Several geostatistical realizations each for the geologically diverse reservoir types covering the pre-defined parameter-space are up-scaled, faulted and simulated with an appropriate production strategy for an approximately 20 year period. The production and reserves uncertainty associated with geological uncertainty and methodological imprecision are quantified as a function of the underlying geology. Production results and recovery factors are combined with the geological and dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Generation of a business plan for the production of a compact and reliable device able to measure in real-time the cerebral  workload state of high responsibility operators in the transport domain' in the context of a Horizon 2020 call.

assistant: **Objectives**

The present proposal aims to generate a business plan related to the realization and commercialization of an already developed prototype able to track in real-time the cerebral workload of aircraft pilots or other operators in the transport domain. Such operators could be for instance the Air Traffic Controllers (ATCos) or those devoted to control the traffic of an high speed train network or subway. The developed device, named BrainWorkloadReader (BWR) will be used: i) during training-assessment programs, to quantify the progress of the learners in terms of amount of cognitive resources requested during simulated or real tasks; ii)  during the normal daily activities of an operator in order to monitor in real time his/her cerebral workload for traffic control of airplanes, trains or cars in specialized control rooms. The BWR device consists in a easy wearable cap with 6-8 electrodes connected in a wireless way to a portable recording systems. The already developed prototype has the size of a smartphone and it is able to return information about the level of cognitive workload of the operator (e.g pilots, ATCos etc etc). The BWR device has no counterpart actually in the market, and its role will be not limited to the transport domain but it is potentially applicable in every situation in the close future in which there will be an operator and a task to be performed. This means that it will be possible to measure the level of cerebral effort across different contexts, including operators in remote surveillance tasks, etc. etc. Possible applications will be in any environment in which a human has to monitor a system or a process and in which the occurrence of an error due to the excessive operator’s workload could have significant consequences for the safety of both the o