RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Uniform inference with time series' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This project proposes a novel econometric approach suited for hypothesis testing and confidence interval construction in the presence of generic time series regressors with arbitrary persistence degree. The project will develop inference for a large class of regressor processes commonly encountered in macroeconomic and financial data, ranging from stationary, local-to-unit-root, explosive, long memory, time-varying parameter and other nonstationary processes as well as multivariate systems containing mixed components. The key idea behind the approach is to build a new explanatory variable from the data which conforms to a standard central limit theory even when the original regressor does not. The resulting instrumental variable estimators based on this endogenously constructed instrument are shown to be asymptotically mixed-Gaussian regardless of the true stochastic nature of the regressor, implying standard inference for any IV-based self-normalised test. The main contribution of the project is to place a large class of nonstandard processes with a wide range of dynamics and memory properties under a common econometric framework which delivers standard inference regardless of the regressor's stochastic properties. The asymptotic development of the procedure requires fundamental theoretical contributions such as a novel Granger-Johansen type representation theory for multivariate time series with mixed stochastic components and the asymptotic analysis of time series with different persistence types. The novel procedure is shown to be valid uniformly across persistence regimes and automatically delivers asymptotically correct inference without a priori knowledge of the regressor's true stochastic nature. In addition to its generality and theoretical coherence, the appro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'CJD and BSE: an integrated molecular and experimental neuropathological analysis of prion neurodegeneration, strain variation and transmission risks'.

assistant: **Objectives**

We will study the transmission characteristics of new variant CJD and its possible relationship with BSE, and further study the molecular basis of prion stain diversity with a particular emphasis on Prion Protein (PrP) glycosylation.In addition, the cellular pathogenesis of prion diseases and the interactions between bovine and human PrP will be examined and we aim to identify mutant prion proteins which may induce spontaneous spongiform neurodegeneration.We plan to generate BSE specific antibodies to develop specific assays for BSE diagnosis.Prion diseases are transmissible neurodegenerative diseases of humans and animals; the transmissible agent or prion appears to consist principally of a modified form of a host encoded protein. They represent an increasingly important research area because of both their unique biology and the recent occurrence of an epidemic animal prion disease, bovine spongiform encephalopathy (BSE), which has led to fears of transmission to humans through dietary or occupational exposure. The recent occurrence of a new recognised clinicopathological variant of CJD affecting young people in the UK and now France has led to considerable alarm that these cases represent BSE transmission. Such concerns have had a major impact on the EU agricultural industry, cases of BSE are now being reported throughout the EU. In addition, there have been concerns over the safety of pharmaceutical products derived from human or bovine tissues. Most of the participants in this application are partners in an existing. EC Shared cost action on prion diseases and the current application aims to complement and strengthen this partnership to respond to the challenges posed by BSE. We will attempt to determine whether these new cases are related to BSE by comparative tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Morphodynamic Stickiness: the influence of physical and biological cohesion in sedimentary systems' (GEOSTICK).

assistant: **Innovation**

Our coasts, estuaries, & low-land river environments are some of the most sensitive systems to sea-level rise & environmental change. In order to manage these systems, & adapt to future changes, we desperately need to be able to predict how they will alter under various scenarios. However, our models for these environments are not yet robust enough to predict, with confidence, very far into the future. Moreover, we also need to improve how we use our understanding of modern environments in reconstructing paleo-environments, where significant assumptions have been made in the way in which relationships derived from the modern have been applied to ancient rocks. One of the main reasons our models, & geological interpretations, of these environments, are not yet good enough is because these models have formulations that are based on assumptions that these systems are composed of only non-cohesive sands. However, mud is the most common sediment on Earth & many of these systems are actually dominated by biologically-active muds & complex sediment mixtures. We need to therefore find ways to incorporate the effect of sticky mud & sticky biological components into our predictions. Recent work my colleagues & I have published show just how important such abiotic-biotic interactions can be: inclusion of only relatively small (<0.1% by mass) quantities of biological material into sediment mixtures can reduce alluvial bedform size by an order of magnitude. However, this is just a start & there is much to do in order to advance our fundamental understanding & develop robust models that predict the combined effects of abiotic & biotic processes on morphological evolution of these environments under changing drivers & conditions. GEOSTICK will deliver this advance allowing us to test
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hydrogen Bond Networks as Optical Probes' under Horizon Europe.

assistant: **Concept**

Fluorescence takes place throughout the natural world. Most conventional chemical wisdom proposes that in organic entities, fluorescence occurs in conjugated systems, such as in the aromatics. However, in biological settings, the interaction of light with matter occurs in media built up of dense networks of hydrogen bonds. Recent experiments suggest that it is possible to observe fluorescence from these networks too. This could open the possibility of designing hydrogen-bond networks with enhanced fluorescence, offering enormous fundamental and practical potential.The overarching goal of HyBOP is to decipher, using advanced computer simulations, the exotic optical properties of hydrogen-bond networks and to harness them as probes of water-mediated forces. To achieve this, HyBOP will tackle the following challenges:1) Establish the ground rules for creating fluorescent hydrogen-bond networks in biological materials. 2) Understand how to drive the electrons and nuclei of water networks into regimes where they can fluoresce. 3) Use the optical behaviour of these networks to probe hydrophobic forces in nature. To uncover the complex chemistry of hydrogen-bond network fluorescence, and guide the discovery of new fluorophores, we will deploy state of the art electronic excited-state molecular dynamics in combination with machine-learning techniques. This will provide HyBOP with ground-breaking knowledge which will lay a theoretical framework to motivate development of new experimental probes of hydrophobicity.HyBOP seeks to bring hydrogen-bond networks to the forefront of chemistry in their use as optical probes; by laying the theoretical ground-work for designing non-invasive fluorophores in biophysics, opening up a new window into the origins of autofluorescence in medical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Harnessing Robotics, XR/AR, and 5G for a New Era of Safe, Sustainable, and Smart Agriculture' (AgRibot), addressing dissemination and exploitation.

assistant: **Impact**

AgRibot is a groundbreaking project aimed at advancing robotics as well as augmented and extended  reality (AR/XR) technologies within the agricultural sector. The project’s overarching goal is to achieve a range of critical impacts including: improving working conditions, reducing environmental footprint, addressing workforce shortages, and enhancing overall sustainability and competitiveness. In alignment with strategic initiatives such as the Farm-to-Fork Strategy, the Common Agricultural Policy post-2022, and the broader ambition of embracing the Digital Age, AgRibot is poised to drive a transformative shift toward a fair, safer, and resilient agriculture sector.


**Keywords:** Agriculture Robotics; AR; XR; Worker Safety; Advanced Robotics; Agricultural Efficiency; Labor Shortage Solutions; Environmental Impact Reduction; Farmers workers Safety; Farmers Community Network;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'LAM561 BEATS PANCREATIC CANCER' (PANC561), addressing dissemination and exploitation.

assistant: **Impact**

Pancreatic cancer is a highly aggressive type of cancer, with poor prognosis and few effective therapeutic options. At the time of diagnosis only 20% of patients are eligible for surgery, the development of metastasis has already occurred. The life expectancy of these patients is 6-11 months (stage3) or 2-6 months (stage IV). Laminar Pharmaceuticals SL is pioneer in the development of bioactive molecules that act through modulation of the lipid composition of the cell membrane regulating key signaling pathways for different pathologies, including cancer.   Recently, Laminar Pharma has demonstrated the high safety and promising efficacy of its most advanced drug in clinical development, LAM561 which is being developed for the treatment of glioblastoma. The clinical study phase IIb/III of LAMP561 in glioblastoma, which evaluates the pharmacological safety of LP561 in combination with the standard treatment for this disease, is currently being completed, without observed severe adverse effects attributable to LAM561.  The current project aims to carry out a preclinical study to evaluate the efficacy and safety of the anti-tumor drug LAM561 in cell and animal models of pancreatic cancer as monotherapy or in combination with standard chemotherapeutics. In addition, the study of cell migration in cell and animal models of pancreatic cancer may allow to explore the antimetastatic effect of LP561 pancreatic cancer, opening a new line of development in the company. This project aims to expand the product indications by including data on its safety and efficacy in the treatment of pancreatic cancer which requires urgent solutions.   Therefore, the completion of the preclinical study would allow, at the end of the proposed studies, to launch human clinical trials to give pancreati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanistic insights into the impact of tumor-associated neutrophils on metastatic breast cancer' (InflaMet) targeting Seventh Framework.

assistant: **Abstract**

Metastatic disease is still largely unexplored, poorly understood and incurable. Accumulating evidence indicates that cells and mediators of the immune system can facilitate metastasis. Neutrophil accumulation in cancer patients has been associated with metastasis formation. In mouse tumor models, neutrophils have been reported to be pro- or anti- metastatic, but the underlying mechanisms involved in either function remain largely elusive. This proposal outlines a research program aimed at resolving the pro-metastatic role of neutrophils in breast cancer, as our preliminary data indicate that neutrophils proactively mediate breast cancer metastasis. Using a state-of-the art spontaneous breast cancer metastasis mouse model, we will mechanistically study how neutrophils facilitate metastasis formation and how mammary tumors provoke the metastasis-facilitating function of neutrophils. Building upon my previous studies and our current data, we will focus on the unexplored crosstalk between the adaptive immune system and neutrophils in facilitating spontaneous metastatic disease. These crucial questions will be addressed by undertaking a multidisciplinary approach, involving sophisticated mouse models for metastatic breast cancer, RNA sequencing on tumor-associated neutrophil populations, state-of-the-art mouse engineering, intravital imaging and in vivo neutrophil manipulations. Moreover, we will validate our findings from the mouse metastasis model in human breast cancer samples. We will determine the metastasis predicting power of the identified murine pro-metastatic neutrophil-specific pathways by immunohistochemistry and multi-parameter immunofluorescence on breast cancer samples and blood of untreated patients of which clinical follow-up is available. Thus, we will ide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ARchaeological RObot systems for the World's Seas' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

ARROWS proposes to adapt and develop low cost autonomous underwater vehicle technologies to significantly reduce the cost of archaeological operations, covering the full extent of archaeological campaign.Benefiting from the significant investments already made for military security and offshore oil and gas applications, the project aims to demonstrate an illustrative portfolio of mapping, diagnosis and excavation tasks.ARROWS approach is to identify the archaeologists’ requirements in all phases of the campaign, identify problems and propose technological solutions with the technological readiness levels that predict their maturation for exploitation within 3-5 years.The individual technologies are then developed during the course of the project using agile development method comprising rapid cycles of testing and comparison against the end user requirements.To ensure the wide exploitability of the results the requirements are defined and the solutions are tested in two historically significant but environmentally very different contexts, in The Mediterranean Sea and in The Baltic Sea.Both immediate, low risk and long term, high risk developments will be pursued. In particular:• Fast a low cost horizontal surveys of large areas using customised AUVs with multimodal sensing.• Fast and low cost semi-automated data analysing tools for site and object relocation• High quality maps from better image reconstruction methods and better localization abilities of AUVs.• Shipwreck penetration and internal mapping using small low cost vehicles localising using fixed pingers.• Soft excavation tool for diagnosis and excavation of fragile objects.• Mixed reality environments for virtual exploration of archaeological sites.• Monitoring of changes via back-to-the-site missions.The ARROW
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Adaptive Auditory Mind' (ADAM), addressing dissemination and exploitation.

assistant: **Impact**

Listening in realistic situations is an active process that engages perceptual and cognitive faculties, endowing speech with meaning, music with joy, and environmental sounds with emotion. Through hearing, humans and other animals navigate complex acoustic scenes, separate sound mixtures, and assess their behavioral relevance. These remarkable feats are currently beyond our understanding and exceed the capabilities of the most sophisticated audio engineering systems. The goal of the proposed research is to investigate experimentally a novel view of hearing, where active hearing emerges from a deep interplay between adaptive sensory processes and goal-directed cognition. Specifically, we shall explore the postulate that versatile perception is mediated by rapid-plasticity at the neuronal level. At the conjunction of sensory and cognitive processing, rapid-plasticity pervades all levels of auditory system, from the cochlea up to the auditory and prefrontal cortices. Exploiting fundamental statistical regularities of acoustics, it is what allows humans and other animal to deal so successfully with natural acoustic scenes where artificial systems fail. The project builds on the internationally recognized leadership of the PI in the fields of physiology and computational modeling, combined with the expertise of the Co-Investigator in psychophysics. Building on these highly complementary fields and several technical innovations, we hope to promote a novel view of auditory perception and cognition. We aim also to contribute significantly to translational research in the domain of signal processing for clinical hearing aids, given that many current limitations are not technological but rather conceptual. The project will finally result in the creation of laboratory facilities a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring silencer functions via their associated chromatin factors' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Distal regulatory elements in the genome play a key role in orchestrating tissue- and context- specific transcriptional programs. While activating elements (enhancers) have been broadly studied in the last decades, repressive elements (silencers) remain a ‘mysterious’ class of regulatory regions of the genome, whose characteristics have never been systematically elucidated. In the ""seeking the SIlencer-associated REpressive protein Network” (SIRENseek) project, I aim to identify and functionally characterize silencers and silencer-binding proteins (SBPs) to gain insight into their mechanism of action and ultimately unlock their untapped potential for gene regulation and targeted therapy. To this aim, I will combine state-of-the-art proteomic analyses and high-throughput epigenomic profiling to identify SBPs and assess their relevance in shaping the chromatin landscape. First, I will focus on a repressive transcription factor known to bind silencers and I will use novel proximity labeling technologies to isolate its interacting proteins, thus unveiling other chromatin factors involved in silencer functions. Then, I will interrogate multiple candidate SBPs via a CRISPR screening and test their ability to rewire the chromatin landscape via ATAC-seq. Finally, by integrating this information with epigenomic data, I will identify SBPs with a functional role at silencers and test their ability to establish long-range chromatin interactions via 3D genomic approaches. Together, this interdisciplinary proposal will allow me to map for the first time silencer elements, their associated chromatin factors and the potential 3D interactions that they mediate to repress target genes, thus addressing the existing gap in our understanding of repressive elements.""


**Keywords:** Gene R