RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Orchestration of instinctive drives' (2007-2013).

assistant: **Concept**

A major goal of 21st century science is to protect human health from the growing mismatch between ancient behavioural instincts and modern socio-economic reality. This is especially vital for basic instinctive drives such as appetite, which lead to overeating when food is readily available. The resulting obesity is responsible for 100,000s of premature deaths per year in Europe and North America, and this number is rapidly rising. Sleep is another powerful instinct which substantially contributes to premature human death, for example from car accidents caused by tiredness. Thus “self-destructive” behaviours caused by inappropriate activation of feeding and sleep drives take a devastating social and economic toll in developed countries, and there is a huge unmet need for effective therapies in this area. To design these therapies, we need to understand the brain mechanisms of instinctive drives. However, brain circuits regulating appetite and sleep have only been delineated in the past few years, and their principles of operation are poorly understood at present. The broad aim of my newly-established laboratory is to fill this gap in knowledge. To understand neural signals controlling instinctive drives, and their relationship to well-being and disease, the following questions must be answered: 1) how do neurons that control appetite and sleep generate their electrical and chemical signals? ) how do these neurons interact with each other? 3) how are these neurons altered in disorders of energy balance and sleep? Our objective for the next five years is to address these key unknowns by focusing on neurons known to be unequivocally important for normal sleep and appetite, the orexin and MCH neurons of the lateral hypothalamus.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Molecular mechanisms of programmed cell death (apoptosis) and the development of apoptosis resistance in tumors'.

assistant: **Objectives**

Cancer is still one of the most common causes of death in Europe and any treatments to avoid or alleviate health risk associated with cancer bears the potential to significantly ameliorate the health of the European population. A major rationale in current cancer therapy is based on the understanding that virtually all cells in higher organisms posses a cellular suicide program referred to as apoptosis. Under physiological circumstances, apoptosis is induced as a developmental program or, more frequently, as a consequence of environmental insult. In the latter instance, apoptosis is probably the single most important tumor suppressor mechanism in mammals. Cancer therapy has long relied on empirically derived cytotoxic treatments that are now recognized as relatively unspecific ways to induce cell death, with a certain preference for cancer cells and rapidly proliferating cells. A major clinical problem, of considerable practical importance, is the development of resistance to cytotoxic cancer drugs. From our current perspective, resistance to cytotoxic cancer drugs can be largely explained by the development of resistance to apoptosis. To resolve this problem, the project will study the following key questions:1. What determines the selective apoptotic killing of tumor cells by anticancer agents?2. Which molecular alterations underlie the development of apoptosis resistance in tumor cells and how can these alterations be reversed by specific treatments? In order to develop new strategies for the diagnosis and new therapeutic approaches for the treatment of apoptosis-resistant tumors, the pathways triggering apoptosis in various cell types will be addressed by a detailed analysis of the signaling pathways in various human tissues. We also propose to study the role of var
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Microbial Hydroponics: Circular Sustainable Electrobiosynthesis' (Mi-Hy), addressing dissemination and exploitation.

assistant: **Impact**

For the first time, Mi-Hy brings together Microbial Fuel Cell (MFC) technology and hydroponics, thereby introducing a prosthetic rhizosphere (an extended rhizosphere community) to the typically “soil-less” configuration of hydroponics systems. The Mi-Hy system will modulate nitrogen forms, plant root microbiomes optimise nitrogen uptake, and mobilise phosphorous, averting the need for chemical fertilisers. This circular, sustainable platform turns carbon into biomass and reclaims nitrogen from wastewater streams. Linked through shared microbiomes, the bioelectricity generating Bioelectrochemical System (BES) Microbial Fuel Cell (MFC) platform is: i) optimised to generate electricity from wastewater at 1mW/1mL feedstock (setting a new benchmark for MFCs); ii)  driving wavelength-specific LEDs to optimize photosynthesis; iii) capable of recovering useful biomolecules using adjacent MFCs to modulate the  redox potential of a workhorse Microbial Electrolysis Cell (MEC) performing microbial electro synthesis (MES). This novel development brings together MFCs & MECs. Since these share common microbial constituents, they can be technologically combined without the need for external, (fossil-fuel based) energy sources. To achieve this goal, Mi-Hy aims to design biofilms using metabolic engineering in wild type symbiotic strains. This next-generation hydroponics system has near-future applications in agriculture and in the urban environment. It delivers a smart, decentralized, low power digital infrastructure with sustainable organic solutions, which are in line with the ambitions of the Missions Cities & Climate adaptation (urban agriculture, precision gardening, wastewater treatments, energy generation, synthesis of high value compounds e.g., vitamins). Mi-Hy will also invite
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular and immunological characterization of merozoite antigens and their encoding genes of a theileria species highly pathogenic for small ruminants in china: application for the development of diagnostics and vaccine.' (ADDAV).

assistant: **Concept**

Recently it has been demonstrated that a Thieveries species in China causes a fatal disease in small ruminants. The economic loss due to this previously unknown parasite ( for convenience referred to as Thieveries china) is estimated to be about $24 Mill. Precise and sensitive diagnostic tools for surveillance of the disease/parasite as well as immuno prophylactic means to control/prevent spread of the disease are lacking. The proposed research aims at developing these means required for implementing effective control measures. Serological and molecular genetic diagnostic tools to enable identification of the causative agent and its clear differentiation to other proclaims infecting host and vector will be developed. In defined geographical areas exhibiting a high infection rate these tools will be evaluated. For vaccine development, the protection of cultured attenuated merozoites will be determined. Furthermore, defined merozite antigens will be screened for their property to evoke a response of T cell lines/clones from immunised animals. Identified immune-reactive antigens will be cloned, expressed and used as DNA and/or recombinant antigens in immunisation trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Motivic Integral p-adic cohomologies' (MIPAC).

assistant: **Innovation**

This project aims to study p-adic cohomologies of varieties using tools from motivic homotopy theory. Voevodsky's theory of motives has played a crucial role in solving deep mathematical conjectures. However, motives intrinsically lack a theory of tale p-adic realizations. In this project, we will use logarithmic geometry tools to generalize the motives category and overpass this problem. More specific goals are related to:Develop a theory of integral log-tale motives and realizations. Prove a general comparison between the log-tale p-adic realizations and tame cohomologiesDevelop a theory of motives over log points with an integral Hyodo-Kato realizationSolve structural problems in the theory of motives of logarithmic schemesMIPAC is an innovative project in motivic homotopy theory built to impact several areas within motivic and arithmetic geometry. The project will be completed at the University of Milan, in a leading multi-disciplinary and collaborative environment. I will bring extensive experience in log motives and some unique expertise on non-A1-invariant cohomology theories. I will benefit of the experience and knowledge of the groups of Algebra and Geometry in p-adic cohomologies and motivic homotopy theory. This will facilitate the research in the group and the transfer of knowledge, and expand my experience and intuition, transferable skills, and professional networks. Carrying out MIPAC within a Marie Skodowska-Curie Fellowship will enhance the development of my career as a complete and independent leading researcher, with a reinforced position within arithmetic and motivic geometry. The leading position of the groups and the department will ensure a great network of international researchers with an impact to the disseminations of the ideas of MIPAC.


**K
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Rotaxanes as potential prodrug systems' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to use a simple and versatile hydrogen bond-mediated supramolecular assembly process to derivates bioactive peptides ( e.g. enkephalins ) as rotaxanes. This should affect their properties, e.g. preventing their in vivo degradation by enzymes, and allow tailoring of their cell membrane transport characteristics. The 'molecular capsules ' - sort of ' super cyclodextrins ' -could be designed to allow drug release in response to a specific stimuli ( e.g. for use with ADEPT -type strategies ) or for slow release over time. Currently rotaxanes are seen as rather exotic molecular structures. This project seeks to use the architectures to do something of both fundamental scientific interest (changing peptide and protein properties) and possible industrial benefit (produce new strategy to prodrugs). Encapsulating peptide and protein segments in a rotaxane structure will also change the conformation (folding) of the peptide/protein and so is of further fundamental importance. Main training is in organic synthesis, non-covalent interactions and assembly processes. The project is based on the design, synthesis and characterization of the properties of hydrogen bond assembled rotaxanes using a strategy recently discovered in Prof Leigh's laboratory. However, the experience of the applicant in the synthesis and conformational analysis of other hydrogen bonding motifs may be useful in developing new types of rotaxane systems. Thus, there is complementarity in the skills of both sides and both should benefit from a Fellowship.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Certified Quantum Security' in the context of a Horizon 2020 call.

assistant: **Objectives**

Digital communication permeates all areas of today's daily life. Cryptographic protocols are used to secure thatcommunication. Quantum communication and the advent of quantum computers both threaten existing cryptographicsolutions, and create new opportunities for secure protocols. The security of cryptographic systems is normally ensured bymathematical proofs. Due to human error, however, these proofs often contain errors, limiting the usefulness of said proofs.This is especially true in the case of quantum protocols since human intuition is well-adapted to the classical world, but notto quantum mechanics. To resolve this problem, methods for verifying cryptographic security proofs using computers (i.e.,for ""certifying"" the security) have been developed. Yet, all existing verification approaches handle classical cryptographyonly - for quantum protocols, no approaches exist.This project will lay the foundations for the verification of quantum cryptography. We will design logics and software toolsfor developing and verifying security proofs on the computer, both for classical protocols secure against quantum computer(post-quantum security) and for protocols that use quantum communication.Our main approach is the design of a logic (quantum relational Hoare logic, qRHL) for reasoning about the relationshipbetween pairs of quantum programs, together with an ecosystem of manual and automated reasoning tools, culminating infully certified security proofs for real-world quantum protocols.As a final result, the project will improve the security of protocols in the quantum age, by removing one possible source ofhuman error. In addition, the project directly impacts the research community, by providing new foundations in programverification, and by providing cryptographers with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MMP system for simulated nmr data analysis' (FAST-SIM), addressing dissemination and exploitation.

assistant: **Impact**

NMR spectroscopy has two main application fields: High Resolution Spectroscopy (HRS), for biochemical characterization, and Magnetic Resonance Imaging (MRI), for medical diagnosis.HRS is strategic for the modern chemical and pharmaceutical industry. Multidimensional (MD) NMR, one of the leading techniques, has strong computational demands, forcing users to off-line processing. This hinders complete exploitation of costly experimental data, ever increasing with new-generation spectrometers. Furthermore, conventional systems do not allow multidimensional Maximum Enthropy Reconstruction (MER) in an economical time scale. MER would cut MD acquisition times by a factor of two or more, thus enabling the study of compounds so far considered insufficiently stable to be amenable to NMR characterization.MRI is an important non invasive diagnostic tool. It involves processing huge matrices, for both image reconstruction and image analysis, and new techniques are going to push computational resources even further. Also, MRI users need intensive processing for analysis and interpretation. Computational time is a real bottleneck in this process, with significant impact on the efficiency of the health system when it comes to diagnostic users.The project will realise a parallel software package to analyse and interpret NMR data with highly advanced techniques and capabilities running on a powerful MPP platform from QSW. The main goal of the development is to adopt software packages as an analysis and verification tool, during the design phase of new NMR data analysis equipment for spectroscopy and imaging. This allows to analyse simulated data derived from the design of novel high-performance systems for the study of biological and synthetic samples, in the chemical and the biomedical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Understanding the interaction between metal nanoparticles and biological membranes'.

assistant: **Innovation**

The BioMNP objective is the molecular-level understanding of the interactions between surface functionalized metal nanoparticles and biological membranes, by means of cutting-edge computational techniques and new molecular models.Metal nanoparticles (NP) play more and more important roles in pharmaceutical and medical technology as diagnostic or therapeutic devices. Metal NPs can nowadays be engineered in a multitude of shapes, sizes and compositions, and they can be decorated with an almost infinite variety of functionalities. Despite such technological advances, there is still poor understanding of the molecular processes that drive the interactions of metal NPs with cells. Cell membranes are the first barrier encountered by NPs entering living organisms. The understanding and control of the interaction of nanoparticles with biological membranes is therefore of paramount importance to understand the molecular basis of the NP biological effects. BioMNP will go beyond the state of the art by rationalizing the complex interplay of NP size, composition, functionalization and aggregation state during the interaction with model biomembranes. Membranes, in turn, will be modelled at an increasing level of complexity in terms of lipid composition and phase. BioMNP will rely on cutting-edge simulation techniques and facilities, and develop new coarse-grained models grounded on finer-level atomistic simulations, to study the NP-membrane interactions on an extremely large range of length and time scales.BioMNP will benefit from important and complementary experimental collaborations, will propose interpretations of the available experimental data and make predictions to guide the design of functional, non-toxic metal nanoparticles for biomedical applications. BioMNP aims at answe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Immunological basis of rational vaccine design for hepatitis C virus' under Fourth Framework.

assistant: **Concept**

The major objective of this proposal i8 to develop strategies to design a vaccine against the hepatitis C virus (HCV) through the analysis of the HCV specific immune response. In addition, the involvement of members of the combined group in vaccine development means that the necessary expertise is available to proceed rapidly from characterisation of immune responses to development of vaccine strategies. Hepatitis C virus (HCV) is an RNA virus with a high degree of sequence variability among different genotypes. It is responsible for the majority of blood borne chronic hepatitis. The prevalence of HCV infection around the world is between 0.4 and 2%. Chronic hepatitis develops in at least half the infected patients and progresses to liver cirrhosis in 20% of the chronic cases. Furthermore, most cases of hepato cellular carcinoma are caused by HCV.A first step in designing an HCV vaccine is the identification of the components involved in protective immunity. At present, little is known on the role the immune response plays in the course of HCV infection and whether antigenic variation among different HCV genotypes plays any role in the pathogenesis of hepatitis C.We propose to characterize the immune response to the different HCV proteins inpatients with acute infection who succeed in clearing the virus and those who develop a chronic infection. In the course of these studies we will assess the importance of the immune response with respect to viral clearance and to the pathogenesis of liver disease.To achieve these objectives we will define:1) the antigenic specificity and effectors functions both of HLA class I and class II restricted T cell responses to HCV in the peripheral blood and, when possible, in the liver;2) the quantitative (ELISA) and qualitative (neutralis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A PAN EUROPEAN NETWORK FOR LANGUAGE COURSES' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Learners of languages want to be independent, but they do not want to be left totally alone. The demand for user-friendly self-study materials and services has not yet been met. The FORUM project has been designed to develop these materials and services using the flexibility that telematics allows. Courses will be developed in English, Finnish, French, German, Greek and Italian. Around 1000 language learners across Europe will participate. These learners represent key user groups: independent learners (working from home for reasons of distance, handicap or preference); university students; employers and employees in large companies as well as in SMEs; training/learning professionals in the languages field, including educational institutions.