RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Language, Families, and Society' (LaFS).

assistant: **Innovation**

Building on my previous research on Family Language Policy (FLP), LaFS (‘Language, Families, and Society’) will focus on three types of linguistic minority families—autochthonous, immigrant, and refugee—as a means to elucidating more about how social inequality is perpetuated (or arrested) along linguistic lines, and how policy at the local, national, and international levels can better support linguistic minority families. The project will therefore provide a key means to understanding more about Europe’s three main sociolinguistic challenges: the decline of its many autochthonous minority languages; increased linguistic diversity due to increased mobility among European member states; and the refugee crisis. LaFS will centre on families who speak Irish as a home language (autochthonous); Polish (immigrant); and Arabic (refugee) as a means to understanding the challenges these linguistic minority families face and how these challenges affect their sense of identity, belonging, and overall well-being. This understanding will be broadened by a secondment with the Glasgow Refugee, Asylum, and Migration Network (GRAMNet). LaFS will be hosted by the National University of Ireland, Galway, complementing NUIG’s Centre for Population and Migration Research and UNESCO Child and Family Research Centre. The project will be supervised by Prof. Tadhg Ó hIfearnáin, a leading expert in minority language issues. The secondment will be supervised by Professor Alison Phipps, UNESCO Chair in Refugee Integration through Languages and the Arts. My professional development over the course of the project in terms of innovative research practice; high-impact dissemination and communication skills; and effective project management skills will be invaluable to my long-term goal of embedding soc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Intelligent data extraction'.

assistant: **Objectives**

The objective of INDEX is to make the interactive analysis of the results of engineering simulations performed on HPCN platforms practicable.The very success of HPCN methods in reducing engineering design times and costs has led to a substantial increase in dataset size and number, and the difficulty and cost of analysing and interpreting this data which (i) selectively reduces the proportion of the data returned for analysis by an intelligent and automatic preselection, (ii) automatically and transparently exercise data compression methods, and (iii) present compact alternative representations of features in vector and scalar fields. The end product of INDEX is the INDEX toolset, a portable modular software library, which will provide an integrated software solution to the problem of increased dataset size from engineering simulation. The toolset will be used by the industrial partners British Aerospace, Daimler-Benz and Osservatorio Geofisico Sperimentale within their existing design processes, and exploited externally by the partners through commercial sales of the toolset.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Weight Maintenance by AgRP neurons' to be submitted under Horizon 2020.

assistant: **Abstract**

Obesity and its comorbid sequelae are major health burdens across European nations. Many citizens would greatly benefit from permanent weight loss, but only a few succeed. They rather suffer from weight regain after dieting, often referred to as Yoyo effect. Delineating the largely unexplored, CNS-driven molecular events that impede sustainable weight loss and drive the Yoyo effect is a prerequisite for future therapies, and a major goal of my proposal.Recently, my lab demonstrated unprecedented weight loss in diet-induced obese mice treated with the plant-derived leptin sensitizer celastrol. Our data suggested breakthrough potential for therapeutic anti-obesity strategies built upon leptin re-sensitization, and pointed towards a key role for orexigenic circuitry and AgRP neurons residing in the hypothalamic arcuate nucleus. As 1st objective, we will 1) establish if leptin resistance originates in AgRP neurons, 2) delineate the molecular underpinnings of leptin resistance and leptin resensitization in AgRP neurons, 3) verify novel drug-able leptin signalling components in murine and human iPSC-derived cells and 4) identify leptin sensitizing weight loss drugs. AgRP neurons will also be in the focus of my 2nd objective that targets epigenetic mechanisms of Yoyo dieting. Building upon our own data on epigenetic mechanisms that drive weight re-gain through hyperphagia, we will 1) establish if an epigenetic memory for obesity in AgRP neurons exists, 2) explore by Crispr-Cas9-based trans-epigenetic modulation of AgRP neurons in mice whether resetting the epigenetic memory for obesity can prevent weight regain and 3) demonstrate the human relevance of our new weight regulatory genes in post-mortem human hypothalami of lean, obese or type 2 diabetic donors.Overall, my proposal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Lifecare’s Sencell sensor is an implantable micro-sensor for subcutaneous location, long time, continuous, wireless, real time monitoring of interstitial glucose for diabetes management.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The SENCELL Glucose Monitoring System includes an osmotic pressure sensor, transmitter and mobile medical application. The miniaturized sensor is designed to be implanted into the subcutaneous space of arm wrist or other suitable body sites and requires no battery or wires for the sensor operation and for communication with the transmitter. After insertion, the sensor is designed to function noninvasively, automatically, and continuously for a long term duration that is comparable or longer than existing product alternatives.The miniaturized SENCELL is designed to continuously measure glucose in the interstitial fluid for a long term duration that is comparable or longer than existing product alternatives. Unlike currently used glucose sensors, the Sencell is intended to be implanted subcutaneously on the arm wrist or other subcutaneous places in the body with no sensor part protruding from the skin. Encased in a biocompatible material, the device utilizes a unique osmotic pressure assessment technology, which translates the signal of a physical miniaturized osmotic pressure cell into an accurate glucose reading that can be used for determination of insulin doses and to generate warning signals in case of hypoglycemia or hyperglycemia development.  The inner core of the device is the unique and proprietary osmotic patented pressure cell, which is covered on one side by a semi-permeable membrane. The membrane is enclosed inside the top of a cavity where the pressure transducer is also located. The cavity contains Concanavalin A and Dextran.The use of ConA/Dextran as enzymatic component significantly improves the sensitivity to changes in the blood sugar level while reducing the influence from other substances in the blood. In the final product, the measurement is then re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Energy CHOices supporting the Energy union and the Set-plan' (ECHOES) under Horizon 2020.

assistant: **Objectives**

ECHOES is a multi-disciplinary research project providing policy makers with comprehensive information, data, and policy-ready recommendations about the successful implementation of the Energy Union and SET plan. Individual and collective energy choices and social acceptance of energy transitions are analysed in a multi-disciplinary process including key stakeholders as co-constructors of the knowledge. To account for the rich contexts in which individuals and collectives administer their energy choices, ECHOES utilizes three complementary perspectives: 1) individual decision-making as part of collectives, 2) collectives constituting energy cultures and life-styles, and (3) formal social units such as municipalities and states. To reduce greenhouse gas emissions and create a better Energy Union, system change is required. While technological change is a key component in this change, successful implementation of that change relies on the multi-disciplinary social science knowledge that ECHOES produces. Therefore, three broad technological foci which will run as cross-cutting issues and recurrent themes through ECHOES: smart energy technologies, electric mobility, and buildings. All three technology foci address high impact areas that have been prioritised by national and international policies, and are associated with great potential savings in greenhouse gas emissions.ECHOES’ uniquely comprehensive methodological approach includes a representative multinational survey covering all 28 EU countries plus Norway and Turkey, syntheses of existing data and literature, policy assessments, as well as quantitative experiments, interviews, netnography, focus groups, workshops, site visits and case studies in eight countries. All data collected in the project will be systematised
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanisms of cell fusion in eukaryotes' in the context of a Seventh Framework call.

assistant: **Objectives**

Membrane fusion is a universal process essential inside cells (endoplasmic) and between cells in fertilization and organ formation (exoplasmic). With the exception of SNARE-mediated endoplasmic fusion the proteins that mediate cellular fusion (fusogens) are unknown. Despite many years of research, little is known about the mechanism of cell-cell fusion. Our studies of developmental cell fusion in the nematode C. elegans have led to the discovery of the first family of eukaryotic fusogens (FF). These fusogens, EFF-1 and AFF-1, are type I membrane glycoproteins that are essential for cell fusion and can fuse cells when ectopically expressed on the membranes of C. elegans and heterologous cells.Our main goals are:(1) To determine the physicochemical mechanism of cell membrane fusion mediated by FF proteins.(2) To find the missing fusogens that act in cell fusion events across all kingdoms of life.We hypothesize that FF proteins fuse membranes by a mechanism analogous to viral or endoplasmic fusogens and that unidentified fusogens fuse cells following the same principles as FF proteins.Our specific aims are:AIM 1 Determine the mechanism of FF-mediated cell fusion: A paradigm for cell membrane fusionAIM 2 Find the sperm-egg fusion proteins (fusogens) in C. elegansAIM 3 Identify the myoblast fusogens in mammalsAIM 4 Test fusogens using functional cell fusion assays in heterologous systemsIdentifying critical domains required for FF fusion, intermediates in membrane remodeling, and atomic structures of FF proteins will advance the fundamental understanding of the mechanisms of eukaryotic cell fusion. We propose to find the Holy Grail of fertilization and mammalian myoblast fusion. We estimate that this project, if successful, will bring a breakthrough to the sperm-egg and musc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Thermal, optical and redox processes in molecular conduction junctions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Much of the current intense study of molecular conduction junctions is motivated by their possible technological applications, however this research focuses on fundamental questions associated with the properties and operation of such systems. Junctions based on redox molecules often show non-linear conduction behavior as function of imposed bias. Optical interactions in molecular junctions pertain to junction characterization and control. Issues of heating and thermal stability require a proper definition of thermal states (effective temperature) and the understanding of heat production and thermal conduction in non-equilibrium junctions. This proposal focuses on theoretical problems pertaining to these phenomena with the following goals: (a) Develop theoretical methodologies for treating non-equilibrium molecular systems under the combined driving of electrical bias, thermal gradients and optical fields; (b) provide theoretical tools needed for the understanding and interpretation of new and ongoing experimental efforts involving thermal, optical and redox (charging) phenomena in molecular junctions, and (c) use the acquired insight to suggest new methods for characterization, functionality, control and stability of molecular junctions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving CAR-T cell therapies through AAV-mediated genetic engineering' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

T cells expressing chimeric antigen receptors (CAR) have transformed cell therapies against some hematological cancers. As a postdoc, I evolved a synthetic adeno-associated virus (AAV) with tropism against murine T cells, providing a unique tool to study gene targeted T cells in immunocompetent cancer models. In this proposal, capitalizing on my break-through, I will develop novel strategies to generate gene targeted CAR-T cells in vivo, optimizing AAV delivery in immunocompetent mouse models and combining these methods with technologies for Cas9 delivery for T cell-specific gene editing. The ultimate goal of my proposal is to develop methods that can be translated to clinical trials in humans. Therefore, I will establish a humanized mouse model that allows for targeting of human T cells in vivo, in which key findings from this research project will be translated for proof-of-concept experiments. As the first ever study of gene targeted T cells in vivo, this ground-breaking research will provide in-depth profiling of in vivo engineered CAR-T cells and their therapeutic potential. This study is a necessary first step forwards toward accessible and affordable in vivo generated CAR-T cell therapies in humans. Furthermore, to extend the use of CAR-T cells against solid tumor, I have developed an AAV-based platform to perform pooled knock-in T cell screens in immunocompetent solid tumor mouse models. For this research proposal, I have designed a library of synthetic costimulatory receptors to be expressed with a CAR at the Trac locus to improve T cell fitness and persistence. By combining advanced T cell engineering with analysis on single-cell level, these pioneering experiments will answer crucial questions for T cell therapies and tumor biology. To succeed with my ambitio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A microbial perspective of major historical events in the Southern Cone of the Americas', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Microbes have played fundamental roles throughout our evolution and history. These roles were not only played by pathogens, but also by the trillions of microorganisms inhabiting our body –the microbiome–, which are essential for homeostasis, physiology, and health. Recent advances in ancient DNA research have made possible to study infectious diseases and human microbiomes from ancient human populations, but this field of research is still at its early stages. For instance, it remains largely unknown which were the microbes (including pathogens) that associated with humans in the past, how they have changed over time, geographic regions and historical events, and to which extent these changes shaped our history and fate. This project will combine state-of-the-art methodologies from phylogenomics, microbiome research, and ancient DNA to bring a new perspective to the study of the human past. This approach will be implemented to investigate major aspects of the history of the Americas, using the Southern Cone as a study-model. First, the microbes (including pathogens) and microbiomes associated with pre-contact Native American populations will be characterized. This reference dataset will be then used to evaluate the impact of the agricultural transition and the European colonization in the oral microbiomes and infectious diseases of these populations. Finally, ancient pathogen genomics will be used to reconstruct the epidemiological scenarios of well-documented post-colonial epidemics. From a technical point of view, this project will also contribute new methods and applications to the emerging field of paleometagenomics. Overall, this work will bring unprecedented evidence to long-lasting debates regarding the impact of the agricultural transition in health and the int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'supracellular contractility of myofibroblasts in gut homeostasis and cancer invasion'.

assistant: **Concept**

There has been tremendous progress in understanding the importance of the microenvironment and its chemical signals for homeostasis of stem cell niche in the intestine and for tumor invasion and metastasis formation in many different tissues. However, the way stromal cells such as myofibroblasts or cancer-associated fibroblasts (CAFs) use mechanical forces to shape the extracellular matrix and consequently dictate the response of epithelial cells remains unexplored at the single-cell level mainly due to limited imaging tools. Here we propose a multi-disciplinary approach, at the interface of cancer cell biology and physics, aimed to understand how myofibroblasts contractility influences epithelial cell functions in physiological (homeostasis) and pathological (cancer) conditions using the gut as a model.Specific aims:1. Characterize myofibroblasts in gut mucosa. Using omics analysis, mouse models and optogenetic tools we will obtain molecular signatures of myofibroblasts, characterize their migration, proliferation and contractile capacities.2. Determine the role of myofibroblasts contractility in gut epithelial homeostasis. Using gut-on-chip and intravital imaging we will determine if supracellular contractility of myofibroblasts is necessary to maintain crypt shape upon mechanical stimuli.3. Determine the role of CAF alignment in cancer progression. We will use 3D in vitro models to explore if CAFs alignment prevents or stimulates cancer cell invasion. Using mesentery metastasis mouse model, we will test if CAFs alignment can generate collagen bundles that cancer cells use to metastasize.4. Explore if CAF alignment can induce therapy resistance and tumor relapse. Using human samples of rectal cancer before and after chemo-radiotherapy we will determine if CAFs alignme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Laboratory simulation of turbulent boundary layer pressure fields'.

assistant: **Innovation**

The acoustic source distribution of most real random sources is very complicated. Many types of vehicles are exposed to this type of noise that affects interior comfort and can be a substantial importance to safety. The sound transmission properties of aircraft and automotive structures are characterized by flight-testing or wind tunnels experiments. Due to the complexity and cost of these methods, scientist are starting to think about building test facilities that simulates the characteristics of turbulent boundary layer pressure field. This reproduction has been tried previously, concluding that, due to the electrical and mechanical requirements necessary for the practical implementation of the simulation systems, there was not a satisfactory substitute for the turbulent layer of air. Recently, a new methodology has been proposed for the reproduction of the sound distribution, using an array of acoustic actuators. The initial conclusions are that there is not fundamental reason why the reproduction should not be feasible, but there is additional work that has to be done before this technique can be used in practice. Using these preliminary results as a starting point, more work will be developed to obtain reliable methods of noise estimation. The aim of the proposed research is then to study the feasibility of the simulation in laboratory experiments.