RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Disease insights from single cell signaling' in the context of a Fifth Framework call.

assistant: **Objectives**

Signalling cascades play multiple roles in cell growth, differentiation and death. Their perturbation has profound consequences linked to diseases such as cancer, myopathy and diabetes, major health concerns in Europe. We propose to develop and implement nana technologies, which allow monitoring and examination of intracellular signalling processes in real time at the single cell level. Ourgoals are to create detailed molecular maps of the temporal and spatial organization of proteins involved in signal transudation, in particular insulinsignaling. With this information we can compare diseased and normal tissue to identify specific errors in signalling cascades. Moreover, we can directly development-animal based assays for use in drug discovery. Once established this Nan technology can be extended to the analysis of diverse signalling cassettes in variety of other diseases of high social and economic impact in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Synergies for Europe's Research Infrastructures in the Social Sciences'.

assistant: **Concept**

Europe is facing huge socio-economic challenges: an economic crisis with a young generation in search of jobs, population ageing potentially straining inclusion and innovation of our societies, climate change with its pressures to redesign energy, transport and housing patterns, just to name some of the most urgent “Grand Challenges”. SERISS brings together three research infrastructures in the social sciences: the European Social Survey (ESS), the Survey for Health Ageing and Retirement in Europe and the Consortium of European Social Science Data Archives (CESSDA). Also involved in SERISS are non-ESFRI research infrastructures:  GGP - Generations and Gender Programme; EVS - European Values Survey and the WageIndicator Survey. The overarching objective of this project is to support the Union, the Commission and the Member States to tackle these challenges with a solid base of socio-economic evidence.  The scientific objective of this project is to exploit the synergies among these three infrastructures to their fullest extent and to leverage these synergies to influence the still rather fragmented landscape of smaller infrastructures. Specific bjectives are• to better represent the European population, including target groups of policy measures addressing the Grand Challenges, e.g., young unemployed, older persons in institutions and migrants,• to strengthen cross-national harmonization across Europe by leveraging recent advances in questionnaire design, translation and coding techniques,• to exploit the advances in software technology for cost-effective web-based interviewing, more efficient fieldwork management, and to support new ways of collecting data• to better connect the world of research-driven social surveys with the world of process-generated administrative d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Epidermal growth factor receptor (EGFR) activation by cytohesins - Structural Insights' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The epidermal growth factor receptor (EGFR) is a key player in many biological responses and its aberrant function is associated with numerous diseases, including a number of cancers. Despite the significant benefits of anti-EGFR agents in some tumours, many challenges remain in the improvement of EGFR-targeted therapies.This proposal targets cofactors in the EGFR signalling that, so far, were not exploited therapeutically and hence may not only contribute to the global effort in the understanding of this system but may also open new doors to the development of new therapeutic agents. The aim is to use Nuclear Magnetic Resonance (NMR) to obtain structural insights into EGFR activation covering three main aspects: i) modulation of activity by the transmembrane and juxtamembrane domains, ii) the role of the cell membrane and iii) the role of cytohesins in EGFR activation. For this, selected protein constructs will be prepared and their structure and interactions will be characterized. In parallel, new NMR methodology to improve the study of challenging biological samples, specifically EGFR, will be developed. The work plan will provide an innovative and multidisciplinary training covering different areas in Life Sciences and allow the researcher to experience work in an industrial environment through a secondment. We anticipate to obtain structural information that contributes to the global knowledge on these systems and to the discovery novel therapeutic agents. Moreover, the innovative methodologies that will be used in terms of the acquisition of multidimensional NMR experiments have the potential to change the way current investigation of challenging biological samples is done by NMR spectroscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NEXT-GENERATION ROBOTICS FOR SUSTAINABLE AND EFFICIENT THERMAL SHIELDING OF BUILDINGS' to be submitted under Horizon Europe.

assistant: **Abstract**

The ShieldBot project is designed to revolutionize the construction industry by integrating advanced robotics with sustainable practices to tackle critical challenges in renovation and building efficiency. As the demand for energy-efficient buildings increases, traditional construction methods fall short in meeting modern sustainability standards. ShieldBot aims to address this gap through the deployment of specialized robotic solutions (Façade-ShieldBot, Inner -ShieldBot, and Inspection-ShieldBot) each tailored to enhance the energy efficiency of buildings while reducing environmental impact.Façade-ShieldBot focuses on installing thermal shielding on building façades, improving insulation and reducing energy consumption. Inner-ShieldBot is designed for internal renovations, applying similar thermal shielding to walls and ceilings to enhance comfort and efficiency. Inspection-ShieldBot utilizes advanced sensors to assess building exteriors, identifying areas needing repair or insulation improvements, ensuring thorough maintenance and long-term sustainability.Complementing these robots, the Digi-Shield digital twin collects, organizes, and analyses data from the robots’ operations, enabling real-time decision-making and precise planning. The use of Eco-Shield materials, sustainable, eco-friendly insulation options, further supports the project's environmental goals by reducing the carbon footprint associated with traditional building materials.ShieldBot also emphasizes the integration of human-robot collaboration to ensure that robotic solutions support rather than replace human workers, enhancing safety and efficiency on-site. By combining cutting-edge technology with a focus on sustainability and efficiency, ShieldBot aims to set a new standard for construction and ren
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MEG2 Ultra Light TIming Drift Chamber' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The MEG2 Ultra Light TIming Drift Chamber (MULTIDC) proposal concerns the upgrade of MEG an experiment hosted at the Paul Scherrer Institut (PSI) designed to search for the charged lepton flavour violating decay mu in e+gamma. The upgrade aims at a sensitivity of one order of magnitude better than the final MEG result.The MEG upgrade (MEG2) will increase the rate capability of all detectors while also improving the energy, angular and timing resolutions, for both the positron and photon arms.One of the key ingredient of the upgraded detector is a new low-mass, stereo drift chamber that exploit the timing information of all electron clusters produced by a charged particle for event filtering purposes and resolution boosting.The candidate also proposes to study the feasibility of a laser calibration system able to monitor in real time the characteristics of the gas misture and the wires alignment.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a Platform for Deliberative Processes on Nanotechnology in the European Consumer Market' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main idea behind this Support action is to develop a platform for deliberative processes on Nano-science and Nano-technology (NS&T) in the European consumer market. Nanotechnology products are now reaching the consumer markets within a large number of branches. During the last year, the number of consumer products using nanotechnology has more than doubled, from 212 to 475. Clothing and cosmetics top the inventory at 77 and 75 products, respectively.  We will concentrate on deliberative processes concerning human and environmental safety, ethical and moral dilemmas, and perceptions of risks and responsibilities as revealed through a focus on the market interfaces across the value chain of consumer goods. Consumers, citizens and their organisations could be the most important stakeholders in the diffusion process of nano-products in Europe and beyond. The main goal is to evaluate and stimulate the deliberate dialogue, and give scientific support to the stakeholders responsible for this dialogue.  We will  • Evaluate selected deliberative processes in Europe, both at the EU and national level. These evaluations will have a general NS&T perspective, with  special focus on consumption • Identify the needs and interest of relevant stakeholders along this value chain, especially focusing on producers, consumers, NGOs and the civil society. • Develop a deliberative and science based platform for a stakeholder dialogue in Europe and beyond in this area. The main elements of the platform are:  o a) the content,  o b) the participants, o c) the physical and technical solutions and arenas and - at last  o d) the responsibility for a permanent platform. • Formulate Recommendation for research and political actions. The work packages of the project will more or less mirror this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Therapeutic molecules and druggable sites to suppress aberrant ion channel activity in cancer.' (InterTask) targeting Horizon 2020.

assistant: **Abstract**

TASK-3 is a potassium channel member of the recently discovered two-pore potassium channels family (K2P) responsible for the background current maintaining the membrane resting potential. TASK-3 is involved in several neurological diseases but recent studies pointed out its oncogenic potential. TASK-3 aberrant expression was detected in breast, lung and colorectal cancer cells. This research proposal aims at 1) generate antibodies that can directly reduce TASK-3 function. The potency, the binding mode of the best antibodies will be characterized functionally and structurally to provide an atomic-resolution view of the mechanism of binding, paving the way for antibody engineering. The structural approach will also produce the three-dimensional structure of TASK-3, which will deepen our understanding on the biophysical properties of this channel and its involvement in several other pathologies. 2) Reduce TASK-3 activity by understanding the molecular basis of its trafficking to the membrane. The project aims at providing a structural and functional analysis of the complex between TASK-3 and the cation cotrasporter KCC2, a recently identified partner that affect TASK-3 trafficking to the membrane. Structural information on the complex will uncover regions of the channel involved in binding protein partners, opening the possibility of  pursuing these protein-protein interactions surfaces as targets for drug discovery, with the ultimate goal of modulating ion channel activity. I will undertake a multidisciplinary study that spans protein biochemistry, structural biology, electrophysiology and antibody engineering. The project tackles – side by side - basic science questions (ion channel structure and regulation) and translational research (antibody-based therapy). It offers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Preclinical development of squalenic acid and gemcitabine squalene nanomedicine', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the course of the ERC Advanced Grant TERNANOMED, we have discovered that the linkage of squalene (a natural lipid) to many drugs, confers to the resulting bioconjugates the remarkable property to self-assemble as nanoparticles, due to the folded molecular conformation of squalene. This approach is unique and has never been used before. The so called ""squalenoylation"" technology may be considered as a generic platform to construct nanomedicines with high drug loading and targeted drug release triggered by the spacer between the drug and the squalene moiety. Remarkably, it was shown that these nanomedicines were more efficient and less toxic than the parent drugs. The gemcitabine-squalene (Gem-SQ) nanomedicine, our first candidate for further pharmaceutical developments, was shown not only to display an impressive anticancer activity in experimental tumors but also to overcome drug resistance, thus addressing a major challenge in tumor therapy. These pre-clinical data deserve further development towards translation into the clinic for the treatment of the pancreatic cancer, a devastating disease. However, the squalenic acid (SQCO2H), the chemical template essential for the synthesis of the Gem-SQ bioconjugate, is currently obtained through the Van Tamelen reaction which cannot be employed for the preparation of a clinical sample of Gem-SQ, because of the use of CrO3 (a toxic compound) and the poor yield of the reaction. Therefore, the synthesis of SQCO2H represents a lock for further clinical development of our Gem-SQ nanomedicine. The goals of the present proposal are : (i) to perform the total synthesis of SQCO2H through a new « green » chemistry way (which represents in itself a real innovation) allowing (ii) further  regulatory acceptable preparation of Gem-SQ na
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Application of metrics for process improvement for safety critical software', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

We experience problems with completing development projects within time and cost limits, and this is mainly caused by an increasing amount of software in the products. The amount of safety-critical software will increase in new development projects. Hence the quality for customers, and development process itself must be improved in order to demonstrate the quality for customers, and also in order to comply with very strict certification standards.THE EXPERIMENTObjective: We want to develop suitable metrics for software development projects in order to improve estimation, expose problem areas, and also in order to improve the development process itself in respect of quality and productivity.Methodology: The planned methodology for the project is to follow the AMI approach as described in the AMI handbook, which was developed in an earlier ESPITI project. Baseline projects: The experiment will be linked to two baseline project parallel in time, at former Normarc and GAREX respectively. The first one being a project for landing of aircraft based on satellite navigation, and the second one will cover two new releases of software for a voice communication system used in air traffic control.Experiment plan:Assessment and development of metrics for both baseline projects and also for the PIE project itself.Metrication of a limited number of software modules in both baseline projectsAssessment and evaluation of results from phase 1Improvement of metrics and development of new onesMetrication of a new set of limited software modules in both baseline projectsAssessment and evaluation of results from phase 2Final evaluation and conclusionEXPECTED IMPACT AND EXPERIENCEMore accurate estimates and improved control of risk explosion, leading to better decision making.A more cost-effec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'rEaLIzing healthcare 4.0 eXploIting the 6G netwoRk evolutION' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

ELIXIRION will create the first fully-integrated, inter- and multi-disciplinary, highly-innovative training and research network that will set the foundations of the emerging Healthcare 4.0 paradigm by leveraging 6G technologies targeting to: i) provide all citizens/patients with a wide range of services of different requirements, such as ultra-low latency for latency-critical applications, high speed for data hungry services and ubiquitous secure access to healthcare resources, anytime, anywhere, respecting all privacy aspects, and ii) ensure a secure, efficient, and profitable healthcare ecosystem to all involved stakeholders, while creating a sustainable open market easing access to new players. To achieve the aforementioned objective, ELIXIRION will: 1) leverage a gamut of 6G technologies towards a powerful interconnected network for ultra-high performance access to the healthcare ecosystem targeting up to 99,99999% reliability, 100% coverage, down to sub-ms E2E latency, up to 1 Tbps capacity, high energy- and cost-efficiency, while supporting a massive number of connections, 2) design edge-aware algorithms leveraging diverse computing capabilities offering ultra-fast task execution through parallelization, serverless and distributed computing by intra- and inter- edge node orchestration techniques for real-time mission critical healthcare applications, 3) provide an E2E slicing and zero-touch orchestration framework for optimized 6G network performance across the healthcare ecosystem, targeting at full network automation and secure information handling especially when a massive number of medical devices is considered, by leveraging AI/ML, while considering all different network parts and data analytics to derive useful information helping in the decision-making pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'OrganiK - An organic knowledge management approach for small european knowledge-intensive companies' under Seventh Framework.

assistant: **Concept**

Small European companies compete on their know-how and hence have to use knowledge to their advantage. They are constrained by the scarcity of their resources such as land, labor, and capital, thus they must do more with less. As a result, knowledge housed in European SMEs, must be leveraged so that goals can be achieved in an effective and efficient manner. However, knowledge management programs used by larger organisations tend to be expensive, relatively inflexible and are not suitable for European knowledge-intensive SMEs. Traditional knowledge management focuses on top-down, detailed and tightly controlled knowledge repositories, whereas small knowledge intensive European companies practice ad hoc, people-centred work processes and heavily rely on the social structures of the company (i.e. the individual knowledge workers and spaghetti-like team formations). Therefore, the increasing need of European knowledge-intensive SMEs for loose-coupled collaboration, ad hoc knowledge sharing and utilisation and open innovation structures adoption practices has led to the strong requirement of a next generation knowledge management system that manages and promotes social structures. OrganiK will develop an innovative knowledge management approach, consisting of theoretical KM foundation and technological architecture and tools for the semantic integration of enterprise social software applications, while applying the resulting knowledge management capabilities to the participating SMEs, who actively initiated this ambitious project.