RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Information Aggregation in Elections' (InfoAggregation).

assistant: **Concept**

Elections are the foundation for democratic decision making. This research program will examine the effects of biased and privately informed entities—election organizers—on the ability of elections to aggregate information: Existing theory demonstrates that large electorates can reach correct decisions by aggregating information dispersed among many voters. However, existing theory does not account for the ubiquitous presence of biased organizers who intend to affect the election outcome. Examples of biased organizers may include a CEO holding a shareholder vote, a regional government holding a referendum, and political parties in general elections.This project will develop and analyze new models of voting that account for the effects of biased organizers on information aggregation. One of the examples I consider is an election organizer who can increase voter participation at some cost (e.g., through advertising). Preliminary work suggests that the presence of biased organizers has significant impact. As increasing participation becomes cheap, equilibria exist where the election organizer recruits a large number voters and yet the majority votes almost surely for the organizer’s favorite policy. This failure of information aggregation contrasts starkly with existing results for elections in which the number of voters is exogenously large. I will study the effectiveness of institutional safeguards against such manipulation, including supermajority rules, publicity requirements, and the regulation of communication to voters, and I will apply the theory in the context of shareholder voting and corporate control. Thus, this research program has important implications for the design of elections in realistic voting scenarios.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Social administration, social rights and activation : France in comparative perspective'.

assistant: **Objectives**

The project will investigate the links between the administrative structure of social security - especially the varying role accorded to organised actors from civil society therein - and the scope for and development of the activation of social benefits. These are two themes that are at the centre of current debates on the evolution of the European social model, but are rarely considered in terms of their inter-relationship. The inter-disciplinary research seeks to build on a series of empirically generated and theoretically informed hypotheses about disinter-relationship by subjecting them to closer empirical scrutiny. The empirical strategy will involve widening prior research on the French and British cases to look at a carefully selected third case, the Netherlands. It will also involve deepening the existing research by testing hypotheses against empirical data from different sources: semi-structured interviews with policy actors, expenditure and caseload data on the evolution of activation policies, and published policy debates, statements and consultations. The implementation of the project will enhance the substantive expertise and methodological repertoire of the researcher, while cementing existing collaborative networks of comparative welfare state research in Europe. The dissemination of findings will seek to encourage greater reflection on the relationship between procedural models of social security administration and the pursuit of substantive policy aims, such as activation, in the European Union. By investigating the links between forms of social administration, the constitution of social rights and the uneven development of new social policies, the research will contribute to priority European research on relationships between citizenship, democracy an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding epigenetic mechanisms of complex genome editing in eukaryotes' (EPIGENOME), addressing dissemination and exploitation.

assistant: **Impact**

The scientific goal of this proposal is to contribute to our understanding of RNA-mediated epigenetic mechanisms of genome regulation in eukaryotes. Choosing ciliated protozoa as model organisms gives a wonderful opportunity to study the incredibly complex epigenetic mechanism of programming large-scale developmental rearrangements of the genome. This involves extensive rearrangements of the germline DNA, including elimination of up to 95% of the genome. The massive DNA rearrangement makes ciliates the perfect model organism to study this aspect of germline-soma differentiation. This process is proposed to be regulated by an RNA-mediated homology-dependent comparison of the germline and somatic genomes. Ciliate’s genomic subtraction is one of the most fascinating examples of the use of RNA-mediated epigenetic regulation, and of a specialized RNA interference pathway, to convey non-Mendelian inheritance in eukaryotes. The ‘genome scanning’ model raises many interesting questions, which are also relevant to other RNA-mediated regulation systems. One of the most intriguing is a ‘thermodynamic’ problem: the model assumes that a very complex population of small RNAs representing the entire germline genome can be compared to longer transcripts representing the entire rearranged maternal genome, resulting in the efficient selection of germline-specific scnRNAs, which are able to target DNA deletions in the developing nucleus. How is it possible that the truly enormous number of pairing interactions implied can occur in such a short time, just a few hours? RNA-RNA pairing interactions would probably have to be assisted by a dedicated molecular machinery. This proposal focuses on characterizing proteins and RNAs that can orchestrate the massive genome rearrangements in ciliates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metalloradical Catalysis - From Fundamental Studies to Applications' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Over the past decades, metal catalysis has had a tremendous impact in chemistry, its adjacent disciplines and society overall, having gained an omnipresence in academic and industrial research worldwide. Numerous previously unthinkable transformations can nowadays be achieved in a selective and relatively mild manner owing to the metals' unique ability to trigger bond-making and breaking via pathways and principles that are inaccessible to metal-free processes. In this context, the global community has focused primarily on closed-shell, two electron processes for synthetic transformations. By comparison, the field of metalloradical catalysis has seen much less development, although metalloradicals are nature's preferred species to tame radical reactivities under non-precious metal-catalysis in numerous metalloenzymes. This is likely due to our currently limited understanding of metalloradical reactivity and its associated principles, and as such also limited ability to rationally design metalloradical catalysts and catalytic processes. A multidisciplinary approach, which capitalizes on the principles and insights of organic, organometallic and biological processes, will likely be key to meet the next frontier in this promising field. The objective of this proposal is to combine the tools of mechanistic, computational and synthetic organic/organometallic chemistry to explore catalysis with metalloradicals in synthesis, materials research and enzymatic processes. The proposed program will investigate some of the most pertinent questions in relation to the emerging area of remote functionalizations for the selective synthetic access to tailored molecules, olefin migrations and manipulations, and naturally occurring (enzymatic) metalloradical-catalyzed processes in the cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Adaptive Multifunctional Test Rigs for Aeronautical Structures' (AMTRAS) targeting Horizon 2020.

assistant: **Abstract**

CleanSky2 has addressed the development of new aircraft concepts and architectures including new materials and manufacturing. In this respect, Adaptive Multifunctional Test Rigs for Aeronautical Structures (AMTRAS project) will contribute to the CleanSky2 objectives with the development of innovative multifunctional Test Rigs, with high performance instrumentation and multishape capability ready to test structural behaviour of new materials (panels) and full-scale demonstrators (Tail unit)To achieve flexibility with multiaxiality and asynchronous loading conditions, AMTRAS will be built by:• A flexible parallel system based on hydraulic actuators.• Machine Vision based Non-contact deformation monitoring and measurement system• Non-Destructive Testing based on IR Thermography for the detection of structural defectsThe flexibility and accuracy provided by AMTRAS Test Rigs will contribute to time-to-market minimization, reducing the time span from concept to validated design. This is line with the topic JTI-CS2-2016-CPF03-AIR-02-22 since preparation and assembly of different multifunctional testing benches will no longer be necessary. In addition, AMTRAS contributes to one of the targeted achievements for defined in Challenge 2 “Maintaining and extending industrial leadership” FlightPath 2050 Goals in the Strategic Research & Innovation Agenda (SRIA) of ACARE (Advisory Council for Aviation Research and Innovation in Europe). According to the SRIA, innovation in aviation is complex, capital intensive and takes time, typically, 15 years can elapse between the generation of a concept and technology being fully developed for a specific application on the next generation of air vehicles. However, market demands shorter cycles of new technology integration, therefore greater eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Rational design of a lipopolysaccharide adjuvant for tuberculosis vaccines', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Tuberculosis, a disease caused by the bacterium Mycobacterium tuberculosis, kills 2-3 million people per year. Although an attenuated strain of M.bovis called BCG is widely used as vaccine against TB, its effectiveness is generally considered as insufficient. Our new approach for BCG improvement is to add a novel type of adjuvant, based on genetically engineered versions of the lipopolysaccharide (LPS) from Neisseria meningitidis (Nm). The modifications aim at (i) specific targeting to dendritic cells where an immune response is initiated, and (ii) reduction of toxicity by making the lipid A part less active for the LPS receptor TLR4/MD2. The inactivation of the lgtB gene results in Nm LPS with a truncated oligosaccharide lacking the terminal galactose which specifically binds to the receptor DC-SIGN on human dendritic cells and this binding skews the resulting T-cell response in a Th1-direction. Heterologous expression in N.meningitidis of the pagL gene from Bordetella bronchiseptica, which encodes a lipid A deacylase, results in penta-acylated Nm LPS of strongly reduced TLR4-activating ability. By controlling the degree of PagL-mediated deacylation, different ratios between penta- and hexa-acylated forms can be obtained which display a continuous range of TLR4-activating capacity. Moreover, mass spectrometric analyses of the Nm LPS have shown that, in addition to penta- and hexa-acylated LPS forms, at least eight other structural variations in the molecular species may occur. At present, the relevance of these structural variants for adjuvant activity and reactogenicity is only partially known. Therefore we will develop a methodology to isolate and structurally identify the different LPS molecular species and test them for the desired level of adjuvant activity withou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ion Channels and Receptors Operation' (ICaRO) targeting Horizon 2020.

assistant: **Abstract**

Our understanding of ion channel operation is limited to inferences based on functional data and to static snapshots of their structures where they are available. Cyclic nucleotide-modulated channels and calcium-activated K+ channels play crucial roles in a myriad of physiological processes ranging from signal transduction to neuronal excitability. The binding of ligands to specialized intracellular domains modulates the opening/closing (gating) equilibrium of these channels. Both the high resolution structures - in open and closed conformation - of these channels and the precise mechanism of ligand-mediated channel activation are unknown. The present proposal aims to understand the mechanism of ion channel modulation by ligands. To accomplish this goal we will utilize prokaryotic homologues of these channels reconstituted in artificial membranes. High-speed atomic force microscopy (HS-AFM) will allow us to directly observe individual ion channel molecules in action at high spatiotemporal resolution and in physiological conditions. Through UV-laser pulses caged ligands (caged-Ca2+ or caged-cAMP) will be liberated during HS-AFM imaging and the conformational changes associated to ligand binding monitored in real time. Differences between liganded and unliganded channel structures will provide insight into the mechanism of ligand gating. The obtained data will be compared to single channel current recordings under comparable conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Circular BIOeconomy TRANSFORMation for regions by enabling resource and governance networks' in the context of a Horizon Europe call.

assistant: **Objectives**

BIOTRANSFORM provides European policymakers with an adequate assessment and policy development framework, knowledge base and expert support ecosystem to accelerate the transition from linear fossil-based systems to circular bio-based systems. It is therefore operating at the interface between the circular economy and the bioeconomy transitions. In this way, BIOTRANSFORM equips policymakers with the tools to set informed priorities that serve environmental, economic, and social goals, being actionable, future-proof, and align with supply-and-demand trends in related industries and value chains. BIOTRANSFORM’s “assessment package” will be tested by and provided for European policymakers, which will include 3 complementary tools: (i) resource flow analysis tool including circular innovations, (ii) a cutting-edge quick environmental, social and economic assessment tool, and (iii) a logistics management tool. To achieve this, BIOTRANSFORM develops and tests its framework to establish and roll out circular bio-based systems by applying a multi-actor approach around 6 regional cases: Andalusia (Spain), Northern Burgenland (Austria), Western Macedonia (Greece), Finland, Charles Spa Region (Czech Repulic) and North Rhine-Westphalia (Germany). These regional case studies represent several important industries and scenarios for Europe such as: forestry, agri-food, lake ecosystems, lignite and minerals, and chemicals. Action roadmaps will consider specific regional available resources and infrastructures, conversion pathways, logistics, current policies, strategies, and access to finance.  In other words, BIOTRANSFORM builds on the concept of regenerative bioeconomy value cycles by tapping into what is there already and connecting the dots. In this concept, carbon is stored and nut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards the total synthesis of Miharamycin and related nucleoside antibiotics' under Sixth Framework.

assistant: **Concept**

The research program will focus on the total synthesis of the miharamycins, the development of synthetic approaches allowing access to these nucleoside antibiotics and a range of analogues, for biological testing purposes.The miharamycins possess combined structural features of monosaccharides, nucleosides and peptides. Potent biological activity of nucleoside antibiotics has provoked a large amount of synthetic interest.However the miharamycins themselves have not yet been synthesised and the absolute stereochemistry at one chiral centre is as yet unknown. The miharamycins are potent inhibitors of Pyricularia oryzae, which produces rice blast, and as such are important targets for the improvement of food production.The synthetic studies will consist of three phases: the development of a new approach to the synthesis of the central carbohydrate portion by the use of a ring closing metathesis reaction; the development of methodology for a one carbon extension at C-6 and attachment of the amino acid portion; and finally glycosylation with a purine base to complete the total synthesis.In addition to the total synthesis, a variety of structural analogues will be accessed in a parallel fashion as follows: variation of carbohydrate stereochemistry; variation of amino acid for coupling to C-6; variation of purine / pyrimidine base for installation at the anomeric centre.These studies will provide the first total synthesis of miharamycin and thereby provide structural confirmation of the stereochemistry of the natural product at C-6. They will also produce an extremely interesting set of analogous materials for biological testing which will enable the deduction of structure activity relationships.These studies will also entail the development of novel synthetic methodology that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A generic plasma-arc process for toxic waste destruction with co-generation of high value construction materials .' (WASTILE) targeting Fifth Framework.

assistant: **Abstract**

European Union countries produced some 10,302,000 tonnes of hazardous waste in 1990. The toxic components of these wastes are able to leach into the ground water which increases the disposal problem for the future. The targeted activity of this Project is to involve end-users in research to develop and to demonstrate technology directed towards modernisation of existing and newly build waste incinerator plants to convert them into zero emission" factories. Also for the rehabilitation of civil and industrial infrastructures, specifically waste disposal sites. The aim of this Project is to treat with plasma a composite waste consisting of hazardous waste ash and of toxic chemicals, to produce near-to-net shape building tiles."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'In-Line integration and high level visual intelligence (recognisation and quantification of color and form) into food production and processing systems' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

It is the intention of the InVIS project to integrate unique visual intelligence algorithms (recognition and quantification of colour and form) into state of the art food production technology. Though computer vision systems have taken over trivial inspection in various food production and processing lines, human visual inspection still remains a major part of quality control in the food industry in general. Ongoing developments in automated visual recognition in other fields, e.g. medico technology and the printing industry, now makes it feasible to improve process control, by supplying advanced decision parameters, based on quantitative visual information, for the process control. This feedback will enable the process control to respond to changes in product appearance before it becomes critical, thus ensuring a uniform and high quality of the processed products and simultaneously reducing waste. This objective may be realized by combining standard industrial components like CCD-cameras, fast PC's, frame grabbers (video digitizers) and further development of new advanced computer software and feedback electronics with state of the art food processing equipment.