RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing an evolutionary framework for understanding species co-existence: importance of intraspecific genetic variaiton for community ecology' (ComGen) targeting Seventh Framework.

assistant: **Abstract**

The main goal of this IEF proposal is to allow the fellow to develop an entirely new set of theoretical skills complementing her extensive experimental expertise in the area of plant ecology and evolution. Theoretical training will be achieved by developing evolutionary biology models for targeted questions in the area of community ecology. These models will be conceptually novel by incorporating rigorous population genetic theory into long-standing community ecology questions. Models will be developed under the close supervision of two researchers with world-class expertise in evolutionary genetics and community ecology. The training provided by this IEF would be instrumental in boosting the fellow’s career both by providing hands-on training with theoretical modeling and positioning her at the forefront in the nascent field of community genetics. A small portion of the fellowship will be devoted to field and experimental studies using the empirical model Thymus vulgaris and its associated biotic communities in the Mediterranean. This empirical work, by testing explicitly predictions generated by her theoretical models, will capitalize on the fellow’s widely recognized expertise with this empirical system. It will also allow establishing firmly Thyme as a competitive empirical model to make breakthroughs in the field of community genetics that is currently largely dominated by work on a few empirical models, mainly in North America. This IEF proposal would also boost significantly European competitiveness in a new scientific field that, so far, is primarily developed in North America. The work is expected to make lasting contributions to our understanding of how species interact, and evolve to either co-exist stably or drive each other to extinction with broader implic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'INNOVATIVE, SUSTAINABLE AND CIRCULAR PRODUCTION OF PURPLE PHOTOTROPHIC BACTERIA AS HEALTH-PROMOTING INGREDIENT FOR FOOD AND FEED APPLICATIONS'.

assistant: **Objectives**

Europe’s food security and Farm2Fork strategy ambitions require the development of innovative, healthy and bio-based food and feed ingredients. Promoting the Circular Economy also implies using by-products as feedstocks that are currently poorly valorised. Purple4Life will harness the extraordinary metabolic versatility of purple non-sulfur bacteria (PNSB) to upcycle those by-products into a high-quality innovative feed/food ingredient.  PNSB are phototrophic bacteria capable of converting various carbon substrates, such as sugars, alcohol, CO2 or volatile fatty acids, into biomass with interesting nutritional properties. Among the variety of compounds produced by PNSB, the Purple4Life project will specifically focus on coenzyme Q10 (CoQ10), carotenoids. PNSB contain a very large amount of CoQ10, which is at least a hundred times higher than in regular food. This coenzyme has been associated with numerous physiological benefits in human.  The antioxidant properties of carotenoids are also important for human health and have been well documented.  In aquaculture, the use of the natural carotenoid astaxanthin for fillet colour improvment but also for fish health currently relies on the production of Haematococcus pluvialis. Thanks to its huge antioxidant capacity, astaxanthin is also increasingly used as a food supplement. PNSB contain alternative carotenoids which were poorly investigated regarding feed/food applications but for which preliminary data were promising. The composition of PNSB thus suggests it could become a very powerful health-promoting ingredient for food and feed applications.  The results of Purple4Life, while valorising bio-based by-product, will pave the way for the circular production of these spectacular microbes as innovative healthy feed and food
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Calibration procedure for ge detectors used for in situ indoor spectrometry' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The objective of the proposed project is the conversion of an indoor measured spectrum by in-situ *-spectrometry with a portable Ge detector to incident photon flux spectrum. For this, the measured spectrum must be stripped of the partial absorption and cosmic-ray events leaving only the events corresponding to the full absorption of a gamma ray. In the proposed project the events corresponding to partial absorption in the detector will be determined by Monte Carlo simulations for different incident photon energies and angles using the GEANT code of CERN. Knowing the computed shapes of partial absorption continua deduced by the Monte Carlo simulations for differet photon energies. It is therefore possible to convert our measured spectra to total incident photon flux spectrum by applying the full absorption efficiency curve of the detector (which will be determined by calibrated point sources and/or by Monte Carlo simulations). The obtained results will be used as test of numerical simulations converting radionuclide concentrations in building materials to dose rates in an indoor environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unraveling the Life Cycle of Metastatic Cells from Invasion to Outgrowth.' (META-CYCLE).

assistant: **Innovation**

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, accounting fornearly 10% of cancer-related deaths. The majority of CRC-related deaths result from metastaticdissemination, with the liver and lung being the most frequent distant sites of metastasis. Effective therapiesto prevent metastatic CRC progression are lacking. This gap stems from our limited understanding of thecancer-intrinsic and tumor microenvironmental factors that drive advancement through each intermediatestep of the metastatic cascade.Here, we will use systems approaches to unravel the life cycle of metastatic cells, focusing on cancer cellplasticity and interactions with host tissues. First, we will use in vivo CRISPR screening to identify driversof invasion, dissemination, seeding, and outgrowth. This approach will be complemented by single-cellmulti-omics analyses to uncover the regulatory networks governing these processes. Next, we will explorethe dynamics of the liver pre-metastatic niche using single-cell RNA sequencing, proximity labeling, andimmunofluorescence to dissect its metastasis-promoting cellular networks and gradual reversal after primarytumor ablation. Finally, we will identify host factors that regulate metastatic extravasation and vessel co-option by functionally investigating the role of liver endothelial cells throughout metastatic progression.This will be achieved through a combination of in vivo interaction screening, in vitro models, andcomparison to spatial transcriptomic datasets from patient samples.By integrating these complementary approaches, our study aims to provide a comprehensive understandingof the key drivers and modulators of metastatic CRC. These insights could pave the way for the developmentof novel therapeutic strategies a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synthesis of Marine Macrolides and Hybrid Structures as Novel Microtubule Stabilising Anticancer Agents' (MACRO-MSAA).

assistant: **Innovation**

Project Summary and Research Objectives: Dictyostatin is a potent inhibitor of cell proliferation at the Nan molar level, causing cell cycle arrest at the G2/M phase and inducing apoptosis. By sharing the same microtubule-stabilising mechanism as the anticancer drug Taxi, and retaining activity against Resistant-resistant cancer cells, the marine microcline dictyostatin is a potential new chemotherapeutic agent for the treatment of solid tumours. Due to the extremely low isolation yield from the natural sponge source, total synthesis is essential for generating useful quantities of dictyostatin and determining the full structure. The main objective is to develop a flexible and modular synthesis of the 22-member microcline dictyostatin, using methodology developed in the host group, enabling the determination of the configuration at the 11 estrogenic centres and providing material for further biological evaluation. A secondary objective is the synthesis of novel microcline analogues and hybrid structures, which would be tested for tubule bundling and cytotoxicity. Expected Benefits: The researcher will benefit by improving her research training and by expanding her knowledge and experience in the synthesis of biologically active molecules that may have therapeutic potential, a field that she wishes to pursue after postdoctoral work. Not only will there be opportunities to learn and develop new synthetic methodologies, but also to participate in multidisciplinary research at the interface of chemistry, biology and medicine. The Chemistry Department of Cambridge University is a world-renowned institution and the scientist in charge has exceptional experience in the total synthesis of biologically important compounds, particularly anticancer agents, and the development of n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SME oriented Method for succesful CRM implementation with Low Effort' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

In the global market customer satisfaction is one of the key elements. CRM postulates, that an important measure for improving customer satisfaction is the efficient organisation of customer communication across departments and communication channels. State of the art CRM systems provide groupware functionality, communication facilities, integration with office applications and E-commerce functionality. However adoption thereof in goods producing industries and especially in SMEs has been very low. Facing the challenges of tomorrow's market the consortium addresses within SMILE development of a method for the efficient introduction of CRM systems, which is especially tailored to the requirements of SMEs. The method shall be supported by a software tool, which should assist CRM consultants in applying the method.OBJECTIVESSmile contributes to 2 main aspects within KA II:- Smile promotes novel aspects of customisability requirements for organisational standard applications.- Smile propogates the adoption of user centred implementation principles, by advocating an incremental approach. Smile targets at supporting the most important goal of action line II.1.1 in multiple ways:- Smile aims at development of an implementation approach targeted to SME's, to accelerate the modernisation of European SME's and to support their transformation to a competitive organisation in a networked economy.- Smile develops a detailed and differentiated view on these implementation obstacles will be developed.- Smile helps in identifying opportunities for novel services for the implementation of CRM applications and for novel technical architectures required for products.- Smile allows SME's to gain faster entrance into the networked economy, with less implementation effort and with a higher s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Driving tumour antigen presentation by RNA-mediated transdifferentiation' (DART) targeting Horizon Europe.

assistant: **Abstract**

Immunotherapy has transformed cancer treatment, but targeting effectively refractory solid tumors remains a challenge due to poor T cell activation. Downregulation of antigen presentation pathways and lack of professional antigen presenting cells in the tumor microenvironment contribute to immune evasion. My group has demonstrated direct reprogramming of fibroblasts or tumor cells into type 1 conventional dendritic cells (cDC1) cells by overexpression of the transcription factors PU.1, IRF8, and BATF3, moving towards clinical application via a viral gene therapy. Despite its potential for first-in-class therapy, viral approaches still face limitations including inefficient targeting of solid tumors in vivo and challenging scalability.The DART project builds on the ERC-funded project TrojanDC and aims to develop in vivo reprogramming of tumor cells into cDC1-like cells using RNA vectors. I will firstly evaluate the capacity of modified linear, self-replicating, and circular RNA encoding the factors to reprogram fibroblasts in vitro and assess their antigen presentation and cytokine secretion function. Secondly, I will evaluate RNA-mediated reprogramming of cancer cells and assess anti-tumor immunity in vivo as monotherapy and in combination with immune checkpoint blockade. The goal is to optimize RNA vector designs for the most effective in vivo reprogramming considering differences in delivery efficiency, expression kinetics and immunogenicity. Collaborations with clinicians and industry partners like Asgard Therapeutics are integral, ensuring commercialization through novel intellectual property, broad dissemination, and product development.DART will enable RNA-mediated induction of antigen-presenting phenotypes in cancer cells, leading to potent and specific immunity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'I3 Impact Innovate Invest' (I3).

assistant: **Innovation**

The I3 Impact Innovation Invest is a 33 months CSA that addresses the topic  ICT 19 -2015 Technologies for creative industries topic c) Coordination and Support Actions on Convergence and Social Media. I3 will support research results from lab to market making innovation happen. I3 will promote a closer relation between researchers and entrepreneur providing mentorship and tutorship support to researchers and providing access to business angels and investors. The objective is to identify the emerging promising solutions and their feasibility in the Convergence and social media sector within the European research ecosystem. I3 aims to connect them with investors, corporates, institutions and media and with Startup Europe Initiative, in order to help them in accessing the market through selected events and exploitation activities. Living Lab approach will be used to allow business ideas and new technologies to be validated with users and community. I3 will implement a systematic policy review and analysis, applying methods that can effectively be used to solve issues in the domain addressed by the specific ICT19 topic, applying data and evidence methods. A Policy dialogue will be run to identify areas in need of further exploration, in order to advance consensus and bring together key stakeholders from public and private sector, civil society, academia and the media to discuss key policy issues. The dialogues will provide a forum for multi-directional dialogue, strategic coordination for the development of new research agendas, issues on regulatory framework and coordination of policies in Convergence and Social media. I3 will be dedicated to increase the projects outreach and impact bridging the gap between the technologies developed and the access to the market, increas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Lower cost investments castings produced in thin cold ceramic shells' in the context of a Fourth Framework call.

assistant: **Objectives**

The objectives of the project are firstly to develop a new, lower cost and environmentally attractive manufacturing technique for the production of ferrous and non-ferrous investment castings and secondly to exploit attributes of the new technique in order to increase the size of components which can be made by this process. If successful, the scope of application of investment castings could be increased significantly to embrace markets where traditionally their cost and/or size limitation have precluded their use. The project requires the development of materials and process parameters, their validation and then hands-on" foundry demonstration of the new manufacturing technique. A successful outcome will be the production of shells, using water-based as opposed to alcohol-based ceramic slurries, approaching one half of the thickness of those currently used. In addition, it is expected that these thin shells can be filled with molten metal without the need to preheat them to the high temperatures necessary in conventional investment casting practice. An important feature of the new technique is the support provided to the thin shells by free flowing, compacted sand to which vacuum is applied as the moulds are poured."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Ergonomic impact and new Functions induced by Active Inceptor integration in CockpiTS'.

assistant: **Objectives**

The EFAICTS project proposes to develop and integrate in Active Side-Stick Units (ASSU), optimised coupling and haptic functions for both Pilot/Co-pilot and Crew/Autopilot interactions. The concepts will be validated through modelling and evaluation on a simulation bench with experienced pilots.For dual pilot configuration, ASSU technology can provide intuitive tactile cueing in the cockpit — all resulting in increased situational awareness, safety and improved ergonomic, performance and opens a new mode of communication between the pilot and the co-pilot. In addition, with passive inceptors, the principal information transfer from the aircraft to the pilot still remains visual cueing or alarms. Through ASSU, haptic cueing is an efficient and intuitive communication mode with the crew. EFAICTS project proposes a Human-Centred Design approach, in which the end-users are at the heart of the development, from the beginning to the final evaluation phase. This approach will be applied in the four technical work packages about the flight scenarios definition and evaluation; the PF/PNF/AP interactions and transition phases definition; the specification and development of haptic feedbacks and ergonomic requirements; the evaluation of haptic feedback and ergonomic recommendations. The project will focus on a Tiltrotor aircraft and its specificities since operating as both rotary and fixed wing aircraft and as hybrids in the unique conversion corridor.The activities and proposed solutions will lead to situational awareness improvement, crew coordination, workload reduction, better performances and weight reduction. All these benefits will result in more competitive aeronautic Industry in Europe a safer and greener aeronautics transport.The proposed project is lead and conducted b