RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Procuring innovative ICT for patient empowerment and self-management for type 2 diabetes mellitus' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Public procurers in ProEmpower aim to procure a disease self-management solution to help meet the imminent threat of a diabetes epidemic. ProEmpower will make person-centred care reality - giving the patient the steering wheel - for optimal health outcomes. Very significant synergies will be reaped by supporting all 10 action areas of diabetes management in an integrated ICT solution. Early detection, personal decision support, self management and peer support are to be delivered from a platform with full interoperable and secure access to the necessary devices and health records. ProEmpower will apply the internationally acclaimed Chronic Care Model to specify support needs for type 2 diabetes at all stages.  Self-management and treatment will be supported by personalised guidelines and making the best use of clinical data. In this way a quality culture in healthcare will be fostered and learning healthcare systems made reality. Suppliers will be rigorously evaluated after each of the four procurement phases, comprising (I) an open market consultation supported by the European eHealth Competition, (II) specification of architecture and system aligned to requirements of patients, peers and providers, (III) prototype development and testing with end-users and (IV) effectiveness proven in a trial with 200 patients and 40 professionals. Fully rolled out in the four countries, enabled by procurers with the authority and capacity in their countries and regions, ProEmpower will serve 12 million diabetes patients. Reductions in diabetes-related death, amputation, blindness and renal failure promise cost relief of € 53 billion over 7 years in the four countries. Suppliers can expect a turnover of € 5 billion a year. Proven ability to cover the four different health systems prom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of high-density, whole-genome microarrays of single nucleotide polymorphisms' under Fifth Framework.

assistant: **Concept**

A vast need has. arisen to learn about the genetic makeup of many people from different populations. The participants intend to develop tools, DNA chips, more specifically, that will analyse thousands of DNA markers at a time. These tools will provide invaluable information about the functions of (pathways of) genes. We plan to develop such chips to the extent that they will function in a robust, user-friendly way, at a cost affordable to a wider market. The latter will be post-genomics biotech and pharma companies, and regional genetical studies centres.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Project on Ocean Acidification' in the context of a Seventh Framework call.

assistant: **Objectives**

The overall goal of the European Project on Ocean Acidification (EPOCA) is to fill the numerousgaps in our understanding of the effects and implications of ocean acidification.EPOCA aims to document the changes in ocean chemistry and biogeography across space and time.Paleo-reconstruction methods will be used on several archives, including foraminifera and deep-seacorals, to determine past variability in ocean chemistry and to tie these to present-day chemical andbiological observations.EPOCA will determine the sensitivity of marine organisms, communities and ecosystems to oceanacidification. Molecular to biochemical, physiological and ecological approaches will be combinedwith laboratory and field-based perturbation experiments to quantify biological responses to oceanacidification, assess the potential for adaptation, and determine the consequences for biogeochemicalcycling. Laboratory experiments will focus on key organisms selected on the basis of their ecological,biogeochemical or socio-economic importance. Field studies will be carried out in systems deemedmost sensitive to ocean acidification.Results on the chemical, biological and biogeochemical impacts of ocean acidification will be integratedin biogeochemical, sediment and coupled ocean-climate models to better understand and predictthe responses of the Earth system to ocean acidification. Special special attention will be paid to thepotential feedbacks of the physiological changes in the carbon, nitrogen, sulfur and iron cycles.EPOCA will assess uncertainties, risks and thresholds (""tipping points"") related to ocean acidificationat scales ranging from sub-cellular, to ecosystem and from local to global. It will also assess pathwaysof CO2 emissions required to avoid these thresholds and describe the state ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Simultaneous h-infinity feedback stabilization' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content  This project deals with simultaneous feedback stabilization. Certainly, it is a very intuitive notion of robustness. Related works in this area are mentioned by Vidyasagar in his 1985 book. However, these outlined results have been restricted to the case of Hurwitz stability, where, unfortunately, the objectives of performance have not been taken into account In the H-inf nity control theory, the objectives offeedback robustness design are stated in terms of minimization of sensitivity and captured by constructing a generalized plant. Non-standard H-inf nity problems such as the minimization of two separated objective functions, can be viewed as a simultaneous H-inf nity stabilization of two generalized plants. However, this very important class of problems remains still untouched This fact should come from the mathematical weakness of the standard H-infinity theory (the 2-Riccati state-space equations approachJ. Nonetheless, the previous problem should be overcome by the new developments in the theory of linear matrix inequalities (L.M.I). The outcome of the project would allow.  -to remove the conservatism (within a factor ;) in the H-inf nity mixed sensitivity problem. It would permit to cope with large plant uncertainty or to deal with some special problems involving a reference model. -a better initialization of the mu-synthesis procedure in the unstructured uncertainty case. rraining content (objective, benefit and expected impact)  -To improve my knowledg in the robust controlf eld in a group (Dept. of Engineering, University of Leicester) internationally renowned for its theoretical contributions in robust multivariable control and the application of advanced control engineering systems.  -To get new work methods. It would permit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Greening of surface transport through an innovative and competitive CARGO-VESSEL Concept connecting marine and fluvial intermodal ports' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

EU CargoXpress is going to develop a groundbreaking innovative cargo vessel to meet the expectations of green transport and contributing to decongesting of Europe’s roads. It gives particular attention to the role of SMEs not only in the composition of the consortium (2 out of 6 industry partners are SMEs plus 6 research institutions and a public body) but also when delivering the design of the cargo vessel of the future which is particularly suited for the small and medium sized European Shipyards and equipment suppliers.The vessel Concept EU-CargoXpress goes far beyond existing approaches from aspects of•ship equipment (combined superstructure with bridge, crane and sail)•new propulsion Concept (superconducting energy conversion, PODs)•ship structure (lightweight fit for serial production)•maintenance (modularised/ standardised and “boxed” equipment for immediate exchange rather than repair on board)•ship operation (sailor in home base, through fixed routes)and promotes a logistic philosophy which has the potential to revolutionize the Short Sea Shipping (SSS) business in the Motorways-of-the-Sea. It follows the Ryanair approach which has developed service to hundreds of small airports.EU-CARGOEXPRESS will do a similar thing it provides a high tech vessel for medium and small marine or fluvial ports to shorten considerably the remaining road-transport.This will clearly impact on CO2 and other pollutants emission. First calculations show a potential of total fuel savings of 10,3 Mt/year which accounts for 0,63 % of total EU25 energy consumption per year, when applying the concept to the next 3000 newbuildings for SSS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Reducing chemical input in apple production in response to consumer and grower's environmental concerns by increasing the durability of natural disease resistance' under Fourth Framework.

assistant: **Concept**

Durable disease resistance is one of the main objectives in apple breeding. Scab (caused by the fungus Ventuna inaequalis) and powdery mildew (caused by the fungus Podosphaera leucotricha) are the two major diseases of apple; they strongly affect apple quality and yield when they are not strictly controlled by large amount of fungicides. In european orchards, chemical treatments cost 180 M.ECU per year with the overwhelming majority being for scab and mildew control (15 to 20 specific treatments per year). Such a number of treatments raises numerous ecological problems and consumer health concerns, in addition to the economic cost. Apple breeding strategies, based on monogenic resistance from wild related species, have been developed for 50 years to create new resistant varieties. Recently, many newly-created resistant varieties have been attacked by a new race of scab, showing the vulnerability of such monogenic resistance when confronted by pathogen dynamics. New ways of breeding need to be engaged in order to strenghten the already obtained resistance and to achieve durable resistance in apple: polygenic resistance should give much more durable resistance, especially if combined with monogenic resistance by using new molecular biology tools. In the same time, the risk of appearance of new fungal virulences has to be assessed. Within this framework, miS project aims to develop plant material, a pathogen observation network, knowledge and methodologies, basic for the creation and marketing of new apple varieties carrying durable resistance against these two detrimental fungi. It is based on a close collaboration between geneticists, pathologists, breeders, pomologists and nurserymen, and involves several major objectives: (i) characterization of new apple cultivars car
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Brokering China’s Extraversion: An Ethnographic Analysis of Transnational Arbitration' (BROKEX).

assistant: **Concept**

Chinese global engagements are deepening across sectors and geographic regions. The objective of BROKEX is to fill specific gaps in knowledge about how China’s extraversion advances. The project takes an original approach by examining brokers who mediate in transnational fields. It opens the “black box” of China’s global integration by moving beyond descriptions of input and output characteristics to elucidate underlying dynamics. The objective will be achieved in two phases. First, the PI and two postdoctoral researchers will carry out ethnographic case studies in the Pearl River Delta, South China, that yield complementary information on the common challenge of brokering across geographic scales: * Connecting low-cost Chinese manufacturing with African markets; * Integrating Chinese academic research with global scientific communities; * Transnational architecture production. The diverse cases offer insights into the mechanisms of brokerage across distinctive sectors. In the second step, we build on the empirical findings and literature to develop brokerage theory. Social scientific research on brokerage commonly uses the morphology of social networks as its starting point, and focuses on how actors positioned at the intersection between groups operate. BROKEX adopts an innovative approach by examining how actors strategically seek to shape network morphologies in order to bridge gaps between groups. By directing theoretical attention towards relationship formation that precedes acts of brokerage, this line of inquiry advances understandings of how and why brokered connections emerge. Ethnographic case studies combined with critical theorization will generate new knowledge about the processes beneath the “rise of China” ─ one of the most consequential socioeconomic de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Elucidating the role of ultraviolet radiation in melanoma' (MMUVR) targeting Horizon 2020.

assistant: **Abstract**

Melanoma incidence continues to increase across Europe and compared to other cancers, it disproportionately affects young people, causing a significant loss in life-years in those affected. Ultraviolet radiation (UVR) is the only environmental risk factor in melanoma, but the underlying genetic constitution of the individual also plays an important role. However, our knowledge of the gene-gene and gene-environment interactions in melanomagenesis is still very limited and here we will use various cutting-edge technologies to investigate the role of UVR in melanoma initiation and progression. We have developed mouse models of UVR-driven melanoma that closely mimic UVR-driven melanoma in humans and these provide an unprecedented opportunity to dissect how different wavelengths and patterns of UVR exposure affect melanomagenesis. We propose a multidisciplinary programme of work to examine how host genetic susceptibility factors and responses such as DNA damage repair and inflammation affect melanoma development and progression following UVR exposure. We will integrate knowledge from our animal experiments with epidemiological, histopathological, clinical, and genetic features of human tumours to improve stratification of human melanoma and thereby assist clinical management of this deadly disease. Our overarching aim is to develop a validated stratification approach to melanoma patients that will assist in the development of effective public health campaigns for individuals at risk across Europe.


**Keywords:** Melanoma, UVR, Host susceptibility, DNA Damage, Infammation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biosourced biologicals composed of Phytosterols to elicit plant response to water stress and to biotic stress as part of the transition to ecological agriculture' to be submitted under Horizon Europe.

assistant: **Abstract**

BEST-a is a pioneer product based on biosourced phytosterols to deliver sustainability and proven yields gain in water stress conditions. Issued from the proprietary and patented technology developed by Elicit Plant and already authorised in France for corn and soybean: this is a first product to adapt crops to climate change.The objective is to improve the formulation of the product, create new products with same technology to expand usage to other species and other stresses, then to carry out new field tests and to obtain marketing authorisations, with three ultimate goals to help farmers:1-Provide sustainable biosourced product to adjust to climate change,2-Reduce usage of chemicals,3-Ease to grow protein crops with a sustainable approach.Elicit Plants goal is to take a leading position in the global biologicals market thanks to its Phytosterols based products and to achieve a turnover around 450 million euros in 2029, selling its products in more than 15 countries worldwide.


**Keywords:** phytosterols,biotic stress,abiotic stress,climate change,Agricultural products,Bioproducts (products that are manufactured using,biologicals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Self-nanostructuring Polymer Solar Cells'.

assistant: **Concept**

The participant’s research objective is to develop new and viable solar cell architectures in which self-assembled and light-induced nanostructures improve device manufacturing, construction, and operation. The participant, an optical applied physicist whose expertise is nonlinear dynamics, will be hosted by the ICFO-Institute of Photonic Sciences where she will join nanophotonics researchers trained in chemistry, material science, and physics. She will contribute the knowledge of numerical methods for analyzing pattern formation, self-assembling, and light scattering dynamics and will theoretically and experimentally investigate the sunlight absorption and exciton dynamics due to nanostructures. Among many mutually-beneficial long-term benefits of the participant’s involvement at ICFO is the encouragement of future collaborations between the Third country, the U.S., and European research groups. There is increasing environmental, commercial, and scientific interest in organic and polymer solar cells because the technology uses low-cost and biodegradable materials for producing electrical energy, however, challenges remain. In this research proposal, we summarize recent advances and general schemes for improving thin-film solar cells using nanostructures, largely from within the last 5 years. We describe what tools are not yet available and unresolved physical explanations accompanying demonstrated measurements. We cite examples of self-assembled thermally-annealed nanostructures that show promising results, as well as methods that we will develop for modeling and optimizing new solar cell designs. The research proposed here will focus on the designs for stable bulk heterojunction polymer solar cells, however, results from the investigations may also be relevant to othe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Twophoton microscopy analysis of phosphoinositide-3 kinase function during primary and secondary T cell activation in vivo' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The adaptive immune system protects us from nocuous microbes, yet excessive immune reactions can lead to the development of autoimmunity. The initiation of adaptive immune responses takes place in lymphoid organs, including peripheral lymph nodes (PLN). Inside PLN, T cells become activated through the molecular interactions of the T cell receptor with cognate peptide-MHC (pMHC) molecules and costimulatory molecules on dendritic cells (DC). TCR-mediated signals lead to the activation of the phosphoinositol-3-kinase (PI3K) pathway via the PI3K? isoform, which is required for full T cell activation in vitro.However, little is known about the role of the PI3K? during primary and secondary in vivo T cell activation. Here, we will use twophoton microscopy (2PM) to observe the interactions of antigen-specific control and PI3K?-mutant CD4+ T cells and pMHC-loaded DC deep inside PLN of live, anesthetized mice. Comparing the dynamic interaction parameters obtained in 2PM imaging with the flow cytometric analysis of the activation status of control and PI3K?-mutant T cells, we will delineate the precise contribution of the PI3K? for primary T cell activation in vivo.We will furthermore perform an analysis of the secondary activation of control and PI3K?-mutant effector CD4+ T cells in a mouse model of antigen-induced arthritis. Therefore, we will establish an intravital knee-joint 2PM model to follow the dynamic behavior of control and PI3K?-mutant effector T cells with antigen-presenting macrophages in the inflamed tissue. We will combine imaging data with disease scoring, flow cytometry and the use of a PI3K?-specific pharmacological inhibitor for a comprehensive analysis of PI3K? function at sites of inflammation.In summary, we propose to perform an in-depth analysis of the rol