RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs' (InterTAU), addressing dissemination and exploitation.

assistant: **Impact**

There is an enormous and unmet medical need to find efficient methods of prevention, diagnosis and disease- modifying therapies for neurodegenerative disorders, including Alzheimer’s disease (AD), other tauopathies and Parkinson’s disease (PD). The common molecular denominator of tauopathies are pathological forms of tau protein, and in Parkinson’s disease these are pathological forms of -synuclein. Moreover, -synuclein has a distinct role in pathophysiology of tauopathies, mainly in tau hyperphosphorylation and aggregation, and vice versa. Tau pathology relates to conformational changes during oligomerization and assembly resulting in toxicity. Given their role in the pathogenesis, conformationally altered and assembled tau or -synuclein would be a promising molecular target for disease-modifying therapies. However, the field is still lacking a deeper understanding of associated structural changes in the course of assembly and their inducers on the pathway towards pathological forms of these proteins; therefore, the pharma development is hampered. The main aim of the InterTau project is the detailed structural and biophysical characterization of tau and -synuclein -synuclein protein and their variants in monomeric, oligomeric and fibrillar states relevant for AD, other tauopathies. The InterTAU consortium is composed  and academic partners with cutting- edge methodologies suitable for functional and structural characterization of the tau assembly pathway by solution and solid-state nuclear magnetic resonance (NMR), cryo-electron microscopy and cellular assays corroborated by bioinformatics. The mutual transfer of complementary expertise envisaged in the project will facilitate academic outcome and biotechnological development. Specific expertise will be transferred fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synthesis of peloruside A and analogues as novel microtubule-stabilising anti-cancer agents' (PELORUSYN) under Sixth Framework.

assistant: **Objectives**

Novel microtubule-stabilising agents have great potential as cancer chemotherapeutic agents - where there is a need for improved pharmacological profiles, reduced side-effects, and efficacy against otherwise drug-resistant cancers. The 16-membered macrolid e peloruside A is a potent inhibitor of cancer cell proliferation at the nanomolar level. By sharing the same microtubule-stabilising mechanism as Taxol and retaining activity against multi drug-resistant cancer cells, peloruside A represents a potential ne w chemotherapeutic agent to the treatment of solid tumours. Due to the supply shortage from the sponge source, chemical total synthesis is essential for generating useful quantities of peloruside A to enable its pre-clinical development.The primary objective of the proposed project is to develop a flexible and stereo-controlled synthesis of peloruside A, using methodology developed in the host group, in order to provide material for further biological evaluation. A secondary objective is the synthesis of simplified structural analogues, including hybrids with the epothilones, which would then be tested for tubulin binding and cytotoxicity to determine the essential structural characteristics for bioactivity.The applicant will improve her research training and expand her knowledge and experience in the synthesis of biologically active molecules that may have therapeutic potential. Not only will there be opportunities to learn and develop new synthetic methodologies, but also to participate in multidisciplinary research at the interface of chemistry, biology and medicine. The Chemistry Department of Cambridge University is a world-renowned institution and the host scientist has exceptional experience in total synthesis and the development of new synthetic methods. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Architecture as a Cross-Cultural Exchange: The Shinkenchiku Residential Design Competition, 1965-2017'.

assistant: **Innovation**

To open up new lines of inquiry for the writing of architecture history currently caught up in ‘static’ chronological periods, geographic preferences, heroic figures, aesthetic styles, and fixed gender categories, it is necessary to introduce an entirely new analytical research methodology to the field of architecture. This project investigates the possibilities of such alternative approach by organizing history around complex cross-cultural exchanges, or “contact zones”, between different architecture cultures. To elucidate the potentials of such social spaces ‘where different cultures meet and inform each other’, I focus on an unprecedented example in architecture culture where “East” and “West” meet: The Shinkenchiku Residential Design Competition (SKRDC). SKRDC is an international housing idea competition organized by the Japanese architecture magazine Shinkenchiku since 1965. Through not only studying the competition briefs of the past 52 years, the characteristics of the winning entries and multiple honourable mentions and the judges’ final remarks, but also the difference in nuance between the Japanese and English debates resulting from the actual design proposals as well as the wider ‘aftereffects’ disseminating into both Japanese as well as English literature, I trace the reciprocal transfer of architectural knowledge and how that affected larger local and international architectural debates.  While the SKRDC here serves as a qualitative case study to develop and test my analytical research method, the larger aim of this study is to construct a new historical narrative. By applying the analytical model to different architectural contact zones around the globe, I foresee to contribute to the rewriting of the history of modern architecture into a more inclusive a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Information society, work, and the generation of new forms of socia l exclusion' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Summary The project aims at answering the question: What are the social but also the microeconomic implications of the emerging information society?" It focuses on developments in the domain of companies assuming that the informatization of work is a key factor behind the emergence of information society. The project represents a break with traditional technological determinism as it is based on a "bottom up" approach, analyzing the concrete processes of building up an information society by implementing modern information and communication technologies within companies and in inter-organizational networks. This will shed light on the possible emergence of Europe-specific ways to an Information Society. "Technological practice" is used as a key concept, which describes specific ways of embedding information and communication technology applications into organizational forms and cultural patterns. The project will analyse the development process of such technological practices in different intra- and inter-organizational fields, including shop floor co-operation up to regionally based networks of companies and supporting institutions. It will further investigate in what way emerging technological practices within companies are influenced by and exert influence over the institutions of regional and national environments. And it will analyse the social and micro-economic implications of different technological practices. As regards social implications the project will focus particularly on the aspect of social exclusion and integration. In the project a mix of different methods will be applied including case studies. secondary analysis of existing data sets, a company survey, and comparative analysis. Based on the results of the research project an anszer can be given to t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding the Impact of Narratives and Perceptions of Europe on Migration and Providing Practices, Tools and Guides for Practitioners' (PERCEPTIONS).

assistant: **Concept**

Narratives of a “better life” that can become reality elsewhere have always been shaping human migration. The image or idea of a “promised land”, however, might not be real, and newcomers are often faced with obstacles and challenges. Certain narratives and perceptions of Europe influence migration aspirations and false images can not only lead to problems when the image does not hold true, but it might also even lead to security threats or risks to migrants. It is, therefore, of the utmost importance to understand and investigate narratives about Europe, how these can lead to problems and threats, how they are distributed, and, in the next step, find ways to react and counteract them. Perceptions of Europe are formed in the country of residence, and they are based on a multitude of sources. Social media and new communication networks, in addition, have increased the scope and the intensity of distribution of such narratives; furthermore, so-called filter bubbles and echo chambers can lead to isolated misperceptions that are not corrected. Due to new communication technologies, false or incorrect claims become life on their own, raising expectations or disapproval. At the same time, however, these technologies and communication networks might also provide a channel to set an exaggerated image straight and promote a more realistic narrative. It is, therefore, the aim of the PERCEPTIONS project to identify and understand the narratives and perceptions of the EU abroad, assess potential issues related to the border and external security in order to allow better planning and outline reactions and countermeasures. For that purpose, the project will conduct research on the narratives and the myths that are circulating about the EU in countries West- and Central Mediterranean
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ANNEALING-BASED VARIATIONAL QUANTUM PROCESSORS' (AVaQus) under Horizon 2020.

assistant: **Objectives**

Quantum annealers are devices that prepare the ground state of complex many-body quantum models. These quantum processors have a large transformative power -they can solve real-life problems of interest: scheduling, navigation, quantum chemistry, and many others-, and important technological advantages over universal quantum computers -no need for error correction nor accurate gate operations- that make such processors potentially simpler to design, build, and control. The goal of this consortium is to beat the limitations of current annealing devices regarding heating, noise and dephasing by building and operating a coherent quantum annealer based on superconducting qubits with high connectivity, tuneable interactions and long coherence times. The radical vision in AVaQus is to demonstrate the capacity of quantum annealers to act as general-purpose quantum simulators of spin models and non-universal quantum computers for variational algorithms. Our proposal banks on the progress of superconducting quantum technology and on well-developed superconducting qubit circuitry. However, unlike quantum computing, coherent quantum annealers are in earlier stages of development and this project represents a ramp-up effort to develop the core technology -qubits, tuneable couplings, layouts, controls- and ideas for sustainable scalability. Consequent with this vision, AVaQus brings together excellent European research groups and small to medium-sized enterprises, under the common goal of developing an integrated, small-size and fully-functional quantum processor that demonstrates coherent quantum annealing with 5 qubits fully connected in a multi-coupler network. We will also develop comprehensive real-life optimization problems and simulations in quantum chemistry, spin models and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PRODUCTION OF NOVEL FRUCTANS THROUGH GENETIC ENGINEERING OF CROPS AND THEIR APPLICATIONS' (1994-1998).

assistant: **Concept**

This RTD project comprises a multidisciplinary, integrated approach to obtain transgenic crops for the production of novel, tailor-made fructans with a wide range of applications in food and non-food industries.The products that will be manufactured as a result of the technology developed within this project will have profound benefits for the health and well-being of mankind as well as the environment. In food, fructans can be applied as low-calory sweetener, dietary fibre and bulking agent. In addition, fructans may stimulate growth of the health promoting bifidus-flora in the human digestive system. It is anticipated that these developments will result in the availability of a healthier food package for the consumer without making concessions to quality and enjoyment. Non food applications can include the use of fructans and its derivatives as a raw material in the production of biodegradable plastics, cosmetics and sequestrants as well as co-builder for the detergent industry. The biodegradability of fructans and its origin from a renewable resource make it potentially valuable as a 'green' chemical. Therefore, the fructan technology can in principle contribute to the reduction of the waste issue as well as the appeal to scarce materials. So far, fructans have found limited application in food and non-food due to a number of factors, the most important ones being the low quality of the available fructans as well as the poor agronomic performance of the traditional fructan containing crops like chicory and Jerusalem artichoke. These limitations cannot be overcome by traditional breeding practices or chemical processing and hamper severely the development of this, in potential, mega industry. In this respect, genetic engineering of plants offers new perspectives. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Do intermediate-mass black holes exist?' under Horizon 2020.

assistant: **Concept**

With this proposed project I will determine whether intermediate-mass black holes (IMBHs) exist. I propose to use ESA's new Gaia mission, the rich Hubble Space Telescope data archive, and state-of-the-art techniques to investigate systems predicted to exist but not yet found hitherto, such as recoiled hyper-compact stellar systems, red-supergiant mass donors to ultra-luminous X-ray sources, and white dwarf tidal disruption events. The latter can only be detected if black holes with masses less than 1E5 Msun are involved. Using these systems and events we can probe the sphere of influence of the IMBH and determine the black hole mass dynamically.Currently, there are strong indications for the existence of IMBHs, but dynamical evidence, the irrefutable proof of their existence, is still lacking. Whereas the unequivocal detection of an IMBH will be a breakthrough discovery in itself, it has also important consequences for searches of dark matter annihilation signals, it will provide a baseline for the rate predictions of gravitational wave radiation events involving IMBHs, and the properties of a population of IMBHs provides important constraints on the growth of supermassive black holes and galaxies. Finally, if we discover IMBHs in hyper-compact star clusters it validates numerical relativity simulations that predict that merging black holes receive a recoil kick.My membership of Gaia's Data Processing and Analysis Consortium gives me a distinct advantage in analysing and interpreting Gaia data that, through the superb angular resolution, immediate spectroscopic observations and all-sky coverage, provides unique capabilities ideally suited for answering the question whether IMBHs exist.My proposed project is the first to recognize the potential of Gaia (WP1&2) as well as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Passive layER FailuRe Mechanisms for Steel Embedded in Alkali-Activated Slag Materials' (PERFoRM) targeting Horizon 2020.

assistant: **Abstract**

PERFoRM will unveil how in-service environmental conditions influence the stability of the passive layer on steel rebar embedded in concretes based on low-carbon cementitious materials (i.e. near-neutral salt activated slag materials (NnSAS)), when exposed to environmental threats. NnSAS offer high carbon emission savings, compared to other construction materials, however their long-term performance is largely unknown. PERFoRM will implement non-destructive techniques (NDTs) for the in-situ diagnosis of steel reinforced concretes, and in-situ tracing of aggressive ions; along with cutting-edge electrochemical techniques to determining corrosion rates closely resembling in-service concrete structures. Advanced characterisation of the passive layer using environmental XPS, and the steel-concrete interface using u-CT will also be carried out. The main scientific focus areas of PERFoRM will be:• Developing novel durability wireless embedded (D-WirE) sensors for in-situ tracing of aggressive ions (e.g., chlorides) and monitoring of internal factors (e.g. relative humidity, pH) in concrete• Ground-breaking work monitoring chemical and physical changes induced by carbonation/chloride penetration in NnSAS mainly using NDTs• Advanced characterisation of the passive layer growth, breakdown, and failure rates of steel rebars embedded in NnSAS • Creation of service-life models by incorporation of in-situ carbonation and chloride penetration regression models  PERFoRM will bring unique insight about all potential aspects influencing corrosion mechanism and stability of the passive layer forming in steel embedded in NnSAS. This will enable performance-based materials design, and selection of remediation strategies to ensure the safety of in-service novel self-sensing and low-carbon N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Standards of care for cleft lip and palate in Europe' (1994-1998).

assistant: **Concept**

To improve the effectiveness and efficiency of care for European children with clefts of the lip and/or palate.To establish a register of services and resources, review current evidence, and establish common practice guidelines and quality assurance methodology.The concertation will be coordinated by a Steering Group consisting of the cleft palate teams of Amsterdam, Copenhagen, Manchester, Oslo and Stockholm. European services will be surveyed and a network of all member states, and links to Central and Eastern Europe and the New Soviet Republics will be developed. The register of services will include the organisation and funding of care, clinical protocols and record keeping, and resources for clinical research including gene mapping. Systematic literature reviewing according to the protocols of the Cochrane Collaboration will underpin the development of proposals for common clinical guidelines and methodology for outcome assessment. Pilot studies of comparative outcome will be undertaken to provide a basis for discussion of common approaches to quality assurance. The extent of consensus will be determined at a final forum.