RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The aggregation  of p53 in response to changes in the proteostasis network' to be submitted under Seventh Framework.

assistant: **Abstract**

The concept of the proteostasis network (PN) represent a systems biology approach to protein deposition diseases (e.g. neurodegenerative diseases, amyloidoses, type II diabetes). The PN includes all the cellular components involved in the synthesis, folding, and degradation of proteins, as well as the regulatory mechanisms required for maintaining a functioning proteome despite cellular stress, mutations, or protein misfolding.When the misfolded protein load exceeds the capacity of the PN to maintain, protein aggregation can occur. Protein misfolding and subsequent aggregation is already thought to be the main cause of neuronal death in neurodegenerative diseases. Our study on the aggregation of p53, however, is the first report of protein aggregation leading directly to increased cell proliferation of the same cell in which the aggregation occurs by a gain of function mechanism.p53 is a potent tumor suppressor, and it is the most frequently mutated gene in human cancer (approximately half of the cases). We observed that mutant p53 not only strongly aggregated in tumor cells, - thereby already eliminating one copy of p53 – but that it also co-aggregated in a dominant negative way with wild type p53 and its paralogs, p63 and p73, sequestering these tumor suppressors that are pivotal to prevent tumorigenesis.The ability of the PN to cope with mutant or damaged biological material varies with the differentiation stage of cells, as well as deteriorates with cellular senescence. According to our hypothesis, the decline of the PN, particularly its decreasing ability to control aggregation-prone mutant p53 proteins, is one of the contributing factors to the steadily increasing incidence of cancer with age.We are proposing to study the aggregation of mutant p53 proteins in undi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular mechanisms regulating gamete formation in malaria parasites' (1998-2002).

assistant: **Concept**

Transmission of malaria parasites to the mosquito vector is initiated inside the blood meal by the rapid differentiation of gametocytes into gametes. Game to genesis is an explosive event that is strictly regulated by extracellular stimuli. At a permissive temperature game to genesis is triggered within seconds by a small mosquito molecule, xanthurenic acid (XA). The rapid and highly synchronised differentiation response of malarial gametocytes to a defined molecular trigger now offers a unique model to study molecular mechanisms of signal transduction and cellular regulation in Plasmodium. In a discovery-based strategy for the identification of key regulators of game to genesis, the proposed project will use functional proteomics to identify those proteins in P.falciparum gametocytes that are specifically modified in response to XA by (de)phosphorylation, proteolytic processing or other secondary modifications. Candidate proteins will be examined for their role in malaria transmission by targeted gene disruption in P. berghei.Insights will be gained into the role of tyrosine vs. serine/threonine phosphorylation in Plasmodium, and key kinase substrates will be identified. These may include a hypothetical XA receptor, autophosphorylating kinases, and regulators of the cell cycle or proteolytically processed proteins of parasite of host erythrocyte. The proposed project will provide basic insights into signal transduction in Plasmodium and may reveal new targets for pharmacological intervention that would not necessarily be limited to sexual stages. Furthermore, this project will make a unique contribution to the annotation of the P.falciparum genome.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Contribution of Airlines for the Reduction of Industry Nuisances and Gases'.

assistant: **Concept**

Project CARING (Contribution of Airlines for the Reduction of Industry Nuisances and Gases) aims at better understanding how airlines deal with the environmental constraints, currently and in the future. CARING pursues three main objectives in line with Clean Sky’s Systems for Green Operations ITD: - Gather trajectory data from actual flights. These trajectory data will be used in Clean Sky’s simulator to evaluate their environmental impact and will be compared with future optimal trajectories permitted by the progress of the Clean Sky programme. - Understand the current and future environmental constraints and the basis for taxations, emission permits, etc. - Model how airlines deal with the environmental constraints, and how it affects their economics, their operations and their strategy. To be comprehensive, the CARING study covers several models of airlines: regional, low-cost, charter and long-haul. For trajectory data, environmental specialists will work with airlines to record FDR data on a variety of routes (congested airports, secondary airports, medium haul, long haul), aircrafts (turboprops, single aisles, long range) and approaches (regular, CDA) that are relevant for an environmental study. Trajectory data will then be analyzed and synthesized for use within the Clean Sky simulator. For environmental constraints, the consortium will conduct a survey of existing and potential future international rules. At last, an economic modelling will be developed based on the previous surveys and an analysis of the other costs within an airline (crew, delays, missed connections, etc.). This economic business model will help understand how the environmental constraints might affect future airline strategies, fleet and network decisions. The consortium involves 9 airlines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Shri-mar: chain approach to improve the market position for shrimp: processing, peeling and preservation' to be submitted under Fifth Framework.

assistant: **Abstract**

The project aims at improve the quality of shrimp (initially Gringo). An integrated approach is expected to result in a better market position and better economic perspectives for small-scale fisheries. The next changes in the main links of the chain are envisaged. Storage aboard and landing of raw or alive shrimp instead of cooking/cooling with seawater aboard. Land based cooking and machine peeling instead of manual peelings. Mild preservation/packaging without or with reduced amounts of chemical preservatives. These changes will benefit microbiological quality, which is now acceptable due to abundant chemical preservation, as well as organoleptic quality now being poor. Further, the need for a constant quality product con is easier met with by land based processing at controlled conditions. Moreover this is premises for adequate operation of the availed Panda us peeling machine to be adapted for Crannog. And conversely: the envisaged changes in the Chain-chain are expected to have a spin-off for handling and processing of Panda us.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CMOS/magnetoelectronic Integrated Circuits wil Multifunctional Capabilities' (MAGICAL).

assistant: **Innovation**

Spin Transfer Torque Magnetic memories (STT-MRAM) are receiving a growing R&D effort within the microelectronic industry aiming at the replacement of DRAM or SRAM at sub-20nm nodes. MAGICAL seeks to significantly innovate through groundbreaking advances in ultra-low power multifunctional systems based on hybrid CMOS/magnetic technology. With the development of portable electronics and of the Internet of Things (IOT), more and more functions must be embedded on chips: logic/memory, sensing, communication, etc. The current hurdles with today's technology are power consumption, communication bandwidth, processing/ packaging costs. MAGICAL will demonstrate that these limitations can be largely overcome through hybrid CMOS/magnetic technology.The project will follow three main goals:- Firstly, we will strengthen the STT-MRAM technology by investigating two novel ideas aiming at solving two remaining difficulties in sub-20nm STT-MRAM development: the nanostructuration of magnetic tunnel junctions and the long-term data retention. This will open the path to high density (>Gbit) STT-MRAM.-Secondly, we will demonstrate that Digital, analog (3D magnetic field sensing for orientation sensor), RF communication functions can be realized with the same baseline technology as the one developed for STT-MRAM. As a result, these three types of functions can be homogeneously integrated in a single chip, a major improvement compared to conventional heterogeneous integration. The prime benefits expected from MAGICAL are: ultralow power thanks to MRAM non volatility and on-chip computation capability, greatly improved communication functionalities (cloud as well as intrachip communication), reduced process/packaging costs. -Thirdly, through various actions, MAGICAL will aim at narrowing the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Consumer Behavior and Energy Taxation: Exploiting Psychological Biases in Designing a Green Tax Reform' (ALLEGRO), addressing dissemination and exploitation.

assistant: **Impact**

Behavioral economics is playing an increasingly prominent role in the formulation of policies to mitigate climate change, including discussions of how to encourage uptake of energy-saving technologies, and how to increase public concern and openness to the types of taxes and transfers that are necessary to have a significant impact on the problem (Allcott and Mullainathan, 2010).  But the new analyses of individual behavior coming from behavioral economics have not yet been integrated with more traditional analyses modeling individual responses to economic incentives.The goal of the proposed research is to conduct and estimation of consumer responses to a carbon tax – taking account of insights from behavioral economics. The research will identify how the predicted acceptability of a Green Tax Reform and predicted impacts on behavior depend on the assumptions one makes about the psychology of economic agents.This project will bring together the insights of behavioral economics, in particular with assumptions about the psychology of economic agents, and the rigor of applied demand analysis. Behavioral economics’ theories and techniques represent one of the most powerful and innovative advances in economic research in recent years. Empirical demand analysis, pioneered by Richard Stone, Angus Deaton and John Muellbauer, is one of the most solid, sophisticated, and, from an applicative point of view, effective tools constituting the core of conventional microeconomic theory. While traditional economics and behavioral economics are sometimes seen as intellectual competitors, the two approaches are, in fact, complementary.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bio-imaging with smart functional nanoparticles' (BONSAI) under Sixth Framework.

assistant: **Objectives**

The overall objective is the development of ultrasensitive bio-imaging techniques based on novel multifunctional nanoparticles (NPs) with tailored optical and magnetic properties for visualizing complex cellular structures, receptors, tumour cells and tissues. True innovation rests on the capability to combine the preparation of 'ad-hoc' NPs, having different properties and functions, with the development of advanced bio-imaging techniques. The expected improvements of labeling cells and cellular structures with tailored NPs are sensitivity, speed and specificity in the visualization of biological systems. We plan the development of stable colloidal solutions containing non-cyto-toxic, colloidally stable Si-based NPs properly functionalized on the surface in order to improve and tune their optical properties and increase their selectivity in specific biological targets. These NPs will be employed, in cooperation with two SMEs, for the development of optical bio-imaging techniques aiming at: (i) understanding how the genome instructs and orchestrates the functions of cells, organs and organisms; (ii) whole-cell labelling for cell or pathogen detection, cell tracking, cell sorting and cell lineage studies; (iii) optical imaging of tumour cells for early cancer diagnostics. A further task concerns the development of stable colloids of non-toxic, non-immunogenic NPs with: (i) high magnetization, so that NP can be moved in the blood and accumulated in the target organ, (ii) particle size small enough to remain in circulation after injection (iii) narrow size distribution for differential uptake of various tissues. The aim is the development of marketable, well tolerated, highly efficient, specific and economically viable contrast agents for the detection and characterization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mass Spectrometry of Isomeric Ions' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Mass spectrometry (MS) in combination with electrospray ionization (ESI) is one of the principal tools currently used to gain insight into newly developed catalytic reactions. It is used to identify key reaction intermediates and to study their structure and reactivity. This proposal is based on the combination of modern MS approaches with novel experiments in a unique cryo-trapping instrument. This combination allows the study of short-lived ionic species that cannot be studied by other known methods. Our distinguishing feature is the in situ helium-tagging of ions, which allows us to record their infrared spectra via a pre-dissociation technique. Here, we will go beyond this state-of-the-art approach in two directions:(1) The unparalleled advantage of ESI-MS is its high sensitivity to low-abundant and reactive species. The pertinent question at the heart of all reaction mechanism investigations via MS is how the ions found in the gas-phase relate to the condensed-phase reaction. We will address this question using “Delayed Reactant Labelling”, which will directly link condensed phase kinetics to the abundance of isolated gaseous ions. (2) We will take advantage of long storage times in our cryogenic linear quadrupole trap and expand the portfolio of the methods available to address mixtures of ions with the same mass. Isobaric mixtures are resolved in MS by differences in ion mobilities, i.e. the ions are separated by their mass-to-charge ratios and by their shapes. We will perform ion mobility separation directly in the trap by excitation of the ion secular motion using a resonant dipolar electric field. Further, we will combine cryo-trapping experiments with the probing or modifying of the stored ions by reactive collisions with neutral molecules. The mobility exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sex in the Early Modern City: Musical Eroticism in Rome' (SEMCMER).

assistant: **Innovation**

This project examines the role of music in Rome in creating, circulating, reinforcing, policing and subverting norms of gender and sexuality. The methods by which sexuality and the erotic are transmitted by music (of any age) are not wholly understood; through this investigation we learn more about the affective nature of music, and how music can be used as a political and cultural tool. The research identifies eroticism in music in secular song, drawing on madrigals as well as a repertory of strophic song that is marginal within the discipline of musicology, and then, with reference to settings of the Song of Songs and to the liturgy of women saints, explores eroticism in sacred music. A key aspect is the examination of how early modern women and men interacted with music and fashioned diverse identities that were distinguished by class, ethnicity, race, region, religion, gender, and sexuality. The project argues that some aspects of the European project originate in early modern history. The project promotes awareness and understanding of diversity in the history of gender and sexualities and responds to European legislation against discrimination. It is vital to make clear the long history of sexual diversity in Europe, and the long history of music’s role in sexualities, as a means to work against discrimination on grounds of sexuality and to support and encourage a healthy attitude to diversity. This project will be carried out in Los Angeles, New York and Cork. The initial stage of data collection and analysis will take 12 months, with the remaining 24 months spent writing and developing a monograph, hosting an international, interdisciplinary conference in Europe and developing advance research training networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding the molecular mechanisms involved in the fragile X syndrome' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The fragile X mental retardation syndrome is a genetic disease that results from the absence or a defect in the FMRP protein and is the most frequent cause of inherited mental retardation (1 in 4000 males and 1 in 7000 females). FMRP is found in the nucleu s and cell body of neurons as well as in their dendrites and synapses. Recent data suggests that the protein has a role in the regulation of translation, via a small non translated RNA called BC1. FMRP is part of a large mRNP complex and binds to proteins and RNA. Previous studies performed by the host group shown that FMRP itself is translated at the synapses. Further, its absence in knock-out mice significantly alters the translation efficiency of some mRNAs at the synapses. Since brain synapses are impli cated in learning, memory and cognition, the lack of translational regulation at the synapses may well be the cause for mental retardation in the fragile X syndrome, and it is most important to understand the function of FMRP at the synapses. In this proje ct, we will purify the FMRP complex from synaptosomal preparations and characterise the proteins and RNAs bound to the complex. The proposed project is focused to the understand the function of FMRP at the synapses through the identification of RNA and pro tein species to which FMRP binds within neuronal cells. This project will give an important contribution to the understanding of the Fragile X Syndrome. In addition, the data will yield interesting insights into the translational regulation at the synapses , thereby advancing our understanding of gene expression in the synapses.