RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mechanically-Assisted Synthesis of Pharmaceuticals: A Greener Energy Input' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In a world with increasing population and limited resources, the development of new synthetic procedures will not only be judged by their yield and/or product selectivity, but also by their ecological and economical footprint. Mechanochemistry is a branch of sustainable chemistry which involves a rapid and clean way to transfer the energy needed for the chemical transformation, using friction, via either ball-milling or grinding. In this project, we intend to exploit the attractive practical advantages and opportunities that mechanochemistry offers for the development of the sustainable synthesis of complex pharmaceutical products. In particular, the research focuses on the study of a collection of the most useful tools in organic chemistry: alkylation, condensation, addition, cycloaddition and hydrogenation reactions, in both their racemic and enantioselective version. The development, optimisation and assessment of these transformations will be performed using the biologically active barbiturates as synthetic scaffolds. Moreover, through the study and determination of the key kinetic and thermodynamic parameters for the optimised mechanochemical process, and by means of computational chemistry, we will develop and validate a robust predictive model for these kinds of transformation.This project provides a strong foundation for an innovative network that integrates organic, pharmaceutical, analytical and physical chemistry in the common pursuit of becoming greener. This research aims for a cleaner and more efficient synthesis of pharmaceuticals whilst gaining a better understanding of the physico-chemical parameters that govern mechanochemistry. We envisage that this project will open a significant number of new research opportunities in environmentally-friendly synthe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Operando study of the catalytic activity of gold nanoparticles by Surface Differential Reflectivity Spectroscopy (SDRS): from plasmonic response to morphology' under Horizon 2020.

assistant: **Concept**

The outstanding catalytic activity of gold nanoparticles (NPs) on metal-oxide supports has attracted enormous interest not only for fundamental understanding but also for the design and synthesis of a new generation of efficient catalysts. At the current time, one of the main technical challenges for gold catalyst applications is the stability in terms of sintering during use. As for many heterogeneous catalysts, the characterization of the gold NPs morphology in operating conditions is essential for progress towards practical use. The issue is currently treated by X-ray diffraction at synchrotron radiation facilities. The present project (OSCAR) foresees a breakthrough. It aims to develop an optical method, namely Surface Differential Reflectivity Spectroscopy (SDRS), to determine operando at the laboratory the shape and size of NPs on the basis of their plasmonic response. The challenge is to combine non-invasive SDRS measurements for determining NP morphology to reactivity measurements in realistic conditions. The case study is the archetypal case of CO oxidation on supported gold NPs, for which the relationship between NPs size/shape and reactivity is vividly debated. The catalytic activity of gold NPs will be examined both on a reducible substrate, rutile TiO2(110), and on an irreducible substrate, MgO(100) films on Ag(100), to determine the crucial role played by the supporting metal-oxide substrate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unlocking operational excellence in water desalination plants by nanoscale fouling sensor technology' (Excalibur), addressing dissemination and exploitation.

assistant: **Impact**

Global water stress currently impacts 40% of the world's population and is even worsening due to climate change. To counteract the devastating consequences, membrane desalination is exponentially booming with over 22,000 plants already operational in 2022. Although membrane desalination has lower energy requirements as compared to thermal processes, membrane fouling significantly jeopardizes the efficiency of these plants worldwide. It results in higher energy consumption and requires frequent, at times aggressive, cleaning cycles. The latter in turn increase process downtimes and expenditure on cleaning agents while drastically reducing membrane lifetime. The consequence is significant economic losses for operators, a detrimental environmental impact and an increased final price of the drinking water produced. Currently, there exist only corrective measures which are entirely insufficient as they are based on indirect measurements. In stark contrast, our sensor system Excalibur (patent granted in the EU) is the first and only system detecting fouling and cleaning at nano levels directly on a membrane in real-time and non-invasively. This enables a truly predictive process monitoring. Excalibur surpasses existing sensitivity limits by three orders of magnitude and its proprietary AI-based software provides unique and hitherto unattainable operational flexibility with a strong impact on running costs: membrane lifespan is prolonged up to 20%, process downtimes are reduced up to 60%. By optimizing the use of chemical agents, Excalibur also enhances the sustainability of membrane processes. It boosts both energy savings (>10%) as well as economic efficiency (decrease cleaning cost by 25%). According to our projections and B2B business model, we anticipate installing our so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Architectures, morphologies and applications of organic/inorganic nanomaterials containing polyhedral oligomeric silsesquioxane' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Recently, novel nanomaterials with unprecedented properties have attracted great attention, due to the rapid requirement of the emerging technologies in the fields such as biology and microelectronics. In this project, we proposed a novel kind of nanomaterials, organic/inorganic hybirds containing polyhedral oligomeric silsesquioxane (POSS). POSS-containing hybrid polymers with unique architectures will be prepared using advanced polymer synthesis protocols. These hybrid polymers could self-assemble into a rich variety of morphologies in domains with periodicities such as lamellae in bulk or micelle in solution. We will carry out primary test of the resulting POSS-containing nanomaterials for drug delivery applications and explore many other applications such as catalysis and nanoreactors, microelectronics, molecular template, etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Innovative equipment and methodologies for APIs continuous crystallization'.

assistant: **Objectives**

In spite of the substantial erosion of its market share, western Europe (Italy, Spain are respectively first and second producers) still remains the worldwide leader, accounting for 38,9% of the world APIs production and Eastern Europe is growing faster (mainly represented by Hungary). It is then clear that generic APIs represent a strategic industrial field for EU competitiveness, and it is as well clear that this competitiveness is seriously threatened by the emerging competitors in the Far Eastern Countries (China and India above all). The reasons behind this loss of competitiveness is manifold: (i) lower man power costs in the Emerging countries, (ii) lack of regulatory requirements in the emerging Countries, are the most obvious. The CCRYSTAL main objective is to develop a new technology to crystallize pharmaceutical substances, affording fundamental new approaches to obtain products with high purity levels and constant and reproducible crystalline forms at a competitive price, enabling EU APIs industry to regain his competitiveness against Asian Producers. The innovative proposed technologies are based on a new concept crystallizer and on continuous mode operation. Crystallizer is designed in such a way to assure a perfect actuation of elaborated operation strategies, intended to control the main phenomena involved in crystal formation: (i) Primary nucleation; (ii) Secondary nucleation; (iii) Crystal growth. The new technology will be tested on competitive APIs, eventually developing the whole chemical scheme in a continuous manner. Further a single crystallizer (a “repeatable unit”) is then arranged in a crystallization train of three units, to allow flow operation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Soil mineralogy effects on soil crustability and interril erodibility factor' under Fifth Framework.

assistant: **Concept**

To study the effects of soil mineralogy on crust micro morphology, infiltration, runoff, soil loss and in Terrill credibility factor . To develop a model to predict soil crust ability, in Terrill credibility and slope factor for soils with different properties including soil mineralogy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Piloting a Cooperative Open Web Search Infrastructure to Support Europe's Digital Sovereignty', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Web search has become an essential technology and commodity, driving not only future innovations but forming a backbone for our digital economy. Regrettably, currently few non-European gatekeepers control Web search, which creates a biased, one-sided information access centred around economic success rather than the needs of citizens or European values and jurisdiction. This one-sided ecosystem puts pressure on many small Web contributors from science, economy, art, culture, media and society requiring them to optimize their content for a few gatekeepers. A system greatly benefiting the gatekeepers thereby creates a vicious cycle, which leads to locked-in effects and a closed search engine market.To promote an open human-centred search engine market and provide a true choice to users when selecting search engines based on their own preferences, OpenWebSearch.EU proposes to develop and pilot the core of a European Open Web Index (OWI) and the foundation for an open and extensible European open Web Search and Analysis Infrastructure (OWSAI). Our approach is based on four objectives, namely (1) to develop a core suite of search, discovery and analytics services to create, maintain and utilize the OWI; (2) to develop relevant search engine verticals and new search paradigms demonstrating the impact; (3) to establish a network of European HPC-infrastructure, research and business organizations to pilot the OWSAI based on Europes values, principles, legislation, ethics and standards; (4) to stimulate an ecosystem around the OWI. The envisioned infrastructure will not only contribute to Europes sovereignty for navigating and searching the web, it will also empower Europes researchers, innovators and business to systematically tap into the Web as business and innovation resourc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional Genomics on Wood Formation in Eucalyptus' (WOODGENEUS) under Sixth Framework.

assistant: **Objectives**

Wood represents a renewable resource for which demand continuously increases worldwide. Customised wood properties through tree domestication would release pressure from natural forests while meeting the increasing need for wood. To this end, marker-assisted breeding is a promising strategy for tree breeding.However, to be applied effectively in tree breeding, this approach requires the identification of specific locus/loci or allelic form associated with a given phenotypic variation. Therefore, it is necessary to better understand the molecular processes underpinning the variability and plasticity of wood.The objective of WOODGENEuS is to train a Marie Curie fellow in the most cutting-edge technologies of bioinformatics, functional genomics and genetical genomics in order to:- Get a comprehensive picture of the genes involved in wood formation in Eucalyptus, a fast growing tree of major economic importance in Europe.- Integrate quantitative analysis of gene expression (eQTLs) data and genetic mapping information to identify candidate genes controlling wood traits.The overall aim of WOODGENEuS is to provide the Marie Curie fellow with an integrated training and career development programme that caters for his personal and professional development while meeting EU needs for high-level research-trained personnel.These aims will be achieved by a multidisciplinary and intersectorial research training programme spanning bioinformatics, statistics, functional genomics and genetics and involving Eucalyptus breeders and pulp and paper companies as collaborators.The experienced researcher will therefore be exposed to different schools of thought and will be able to combine his basic scientific training with an appreciation of potential commercial applications of his research, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Laser-as-a-Service Digital Platform with Dynamic Beam Shaping for Acceleration of Smart, Decentralised and Sustainable Factory of the Future' (Lasers4MaaS), addressing dissemination and exploitation.

assistant: **Impact**

Digital servitisation of manufacturing allows to produce on-demand customised products, with high quality, flexibility and short lead time. Although this is a win-to-win situation, there is a lack of methodologies. To reverse this trend, the project Lasers4MaaS will spearhead innovations in manufacturing technologies and digital platforms with associated services. The ultimate goal is to enable a 6-point strategy (reconfigure, connect, control, predict, improve, comply) to operationalise the smart, decentralised and sustainable factories of the future.Lasers4MaaS is set to deliver breakthroughs that merge manufacturing technologies with cutting-edge digital innovations. It marks significant scientific and technical advancements in several areas: the latest advances in dynamic beam shaping and modular production schemes to maximise flexibility and reconfigurability; harmonized protocols and distributed/centralised ledgers for data interoperability across factory boundaries; IIoT solutions for remote monitoring/predictive maintenance; real-time AI-based decision support for improved product quality;advanced physics-based digital twins;life cycle-based tools for environmental impact and costing assessment. The Lasers4MaaS digital platform, with its comprehensive range of services and breakthroughs, will be demonstrated in automotive, fusion, food packaging, aerospace and hydrogen sectors, which are considered strategic sectors for reaching the Green Deal objectives.This consortium comprising 4 academic partners, 8 industrial partners and an industry advisory board, ensures a seamless progression from TRL 4 to 6 with well-defined exploitation routes, while supporting standardisation initiatives, such as digital product passport, and facilitating training initiatives and kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Esao 2002, xxix conference european society for artificial organs (ESAO 2002)' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The proposal is to support the 29th Conference of the European Society for Artificial Organs (ESAO 2002). The emphasis will be on state of art" clinical aspects of artificial organs and will focus on a fascinating topic, "Bridging to Regeneration". ESAO 2002 will bring together experts of biotechnology and bioengineering from all over the world. The congress includes pre-congress symposia and working group meetings, invited lectures, round table discussions, peer reviewed communications and poster presentations. Topics include: Artificial Kidney, Liver, Pancreas, Skin, Biomaterials and Biocompatibility, Artificial Organs & Hybrid Systems, Extra corporal Blood purification, Cell & Tissue Engineering, Scaffolds & Cell therapy, Artificial Cardiovascular Prostheses, Cardiac Assist Devices & Artificial Heart, Extra- corporal Circulation, Heart Valves, Stents & Vascular Prostheses, Ethical Aspects, EU Research Proposals. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Microencapsulation of Islets within Functionalized Peg Hydrogel' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Diabetes mellitus has a Europe prevalence of approximately 48 million people, including approximately 1 million with Type I diabetes. Despite the availability of exogenous insulin, life expectancy and quality are still diminished by chronic or late complications of the disease. These complications can be mitigated by restoring near-normal levels of glucose. The most effective strategy to do so relies on transplanting islets from donor tissue (in the form of a whole pancreas or isolated islets). Islet transplantation has evolved as a meaningful treatment option for Type I diabetes, but its widespread application has been limited by the need for immunosuppression and limited donor tissue supply. Theoretically, this membrane serves as a mechanical barrier isolating the graft from recipient leukocytes and antibodies while continuing to allow the diffusion of glucose, water, insulin, oxygen, nutrients, and cellular waste.. This research will focus on microencapsulation of islets with functional coats in order to address many of the shortcomings associated with current techniques of immunoisolation. In this project, the technique of interfacial photopolymerization will be employed to immunoisolate islets with functional PEG hydrogel coats. Encapsulation of islets using interfacial photopolymerization is necessary to achieve higher yields to test in vivo function and immunoprotection of islets encapsulated by this method. The hypothesis is that, by employing interfacial photopolymerization along with the techniques presented in this proposal it will be possible to microencapsulate rodent and canine islets in capsules of adequate quantity and consistent quality and that the function of islets microencapsulated by this method will be equivalent to that of unencapsulated islets i