RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Irradiation driven nanofabrication: computational modelling versus experiment' in the context of a Horizon 2020 call.

assistant: **Objectives**

RADON delivers a state of the art programme which addresses the needs of both research and industry communities working on the advancement of the methods for controlling irradiation-driven nanofabrication, whilst simultaneously training research and innovation staff capable of exploiting modern computational and experimental tools in this area of research and technology.Exposure of a system to radiation results in changes in the system's morphology, electronic, mechanical and catalytic properties. Irradiation of nanosystems especially during their growing or fabrication phase and con-trolling them with the nanoscale resolution is a considerable challenge but if achieved opens enormous op-portunities and will lead to creation of novel and efficient technologies. Currently such technologies provide controlled fabrication of nanostructures with nanometer resolution, although the control of various proper-ties of such structures remains rudimentary. RADON aims at deeper understanding of the underlying molec-ular interactions and the key dynamical phenomena in irradiated nanosystems that will help to improve these nanofabrication technologiesRADON brings together well-established academic and enterprise partners employing both experienced and early career research and innovation staff and provides them with a unique opportunity to gain new research and technical knowledge on atomistic level insights into the key physico-chemical processes behind the irra-diation driven nanofabrication. Assembling and exploiting such knowledge is crucial for the required tech-nological breakthrough necessary for developing controlled nanofabriacation and bringing it to the market place. Progress in this critical field of research will be achieved by utilization of modern computational and mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Individual Robustness in Development and Cancer' to be submitted under Seventh Framework.

assistant: **Abstract**

Biological systems are robust to perturbations, with many genetic, stochastic and environmental challenges having no or little phenotypic consequence.  However, the extent of this robustness varies across individuals, for example the same mutation or treatment may only affect a subset of individuals.  The overall objective of this project is to understand the cellular and molecular mechanisms that confer this robustness and why it varies across individuals.We will address three specific questions:1. Why do inherited mutations have different outcomes in different individuals, even when they are genetically identical and share a common environment?2. What are the mechanisms during development that confer robustness to mechanical deformation?3. How can the loss of robustness be exploited to specifically kill cancer cells?To address the first two questions, we will use live imaging procedures that we have developed that make the C. elegans embryo a unique animal system to link early inter-individual variation in gene expression and cellular behaviour to later variation in phenotypes.  To address the third question, we will apply our understanding of genetic robustness and genetic interaction networks in model organisms to the comprehensive analysis of cancer genome datasets.  The predictions from these hypothesis-driven computational analyses will then be evaluated using wet-lab experiments.Understanding and predicting variation in robustness is both a fundamental challenge for biology and one that is central to the development of personalised and predictive medicine. A patient does not want to know the typical outcome of a mutation or treatment; they want to know what will actually happen to them.  The work outlined here will contribute to our basic understanding of robust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Open Data INcubator for Europe'.

assistant: **Objectives**

The Open Data INcubator for Europe (ODINE) project will set up an environment to support and advice SMEs and start-ups in creating commercial added value from open data. Drawing on the experience from key players in the consortium including Wayra (an incubator/accelerator), Fraunhofer IAIS and the ODI (both data facilitators and incubators), Telefonica (providing computing infrastructure and strong links to data protection and privacy stakeholders), and the University of Southampton (renowned for its open data research and home of Sir Tim Berners-Lee and Sir Nigel Shadbolt), we plan to establish a EU-wide, industry-focused network of open data companies around Europe, promoted and guided by the trusted authorities and commentators at the Guardian and OKFN. To achieve this we shall take an approach that follows ‘best in class’ practice for incubators and which makes it as a simple and smooth as possible for SMEs to apply for help. We will offer: (i) a transparent, fair, and efficient proposal process for SMEs and start-ups, based around Wayra, IAIS and ODI’s existing and successful processes; (ii) a network of European open data SMEs and start-ups; (iii) initial investment in these companies through an open call; (iv) incubation and mentoring by ODI, Fraunhofer and Wayra academies, with the possibility of acceleration via Wayra, Telefonica Ventures, and Fraunhofer Venture; (v) access to data services and computing infrastructure from IAIS, ODI, OKFN and Telefonica; (vi) expert support from serial entrepreneurs and intrapreneurs, and coaching from business schools; as well as (vii) high visibility through promotion of success stories by the Guardian, ODI and the OKFN. A successful open data incubator will significantly help Europe to regain leadership in technical innovat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Envola storage heat pump enables the world’s first highly energy-efficient heating, cooling and ventilation system significantly reducing energy consumption and greenhouse gas emissions in Europe.' in the context of a Horizon Europe call.

assistant: **Objectives**

The heating and cooling of buildings is one main energy consumer in Europe. Especially residential heating is the main emitter of greenhouse gases and other air pollutants and air conditioning systems heavily contribute to urban overheating. Overall, currently the heating and cooling of buildings fosters climate change and causes negative effects on public health. To face this, and to make European buildings more efficient regarding heating and cooling, Envola found the technical solution to bring air conditioning and air heat pumps to the next level of high efficiency. With our Venticer HVAC system the energy consumption can be significantly reduced by >50% for cooling and >30% for heating compared to the best products available. The new Envola heat pump technology integrates the required ventilation system in the same heat pump process. Therefore, the investment cost for this new highly efficiency technology is significantly lower than state of the art systems in daily application.


**Keywords:** Climatology and climate change,Ecology,Sustainable energy,Renewable energies,Low/zero carbon communities,Local sustainable energy supply,Energy efficiency,Smart cities,Smart buildings
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural characterization of the high molecular weight complex of gamma-secretase' (HMWGAMMA) targeting Sixth Framework.

assistant: **Abstract**

Deposition of the amyloid beta peptide (Abeta) in the brain is critical to the pathogenesis of Alzheimer's Disease (AD). Gamma-secretase is a key enzyme responsible for generating Abeta from its precursor protein.Gamma-secretase has attracted a lot of attention recently because:1) it is a highly unusual protease2) it cleaves many important membrane proteins (Notch, cadherins) and regulates subsequent signalling and3) the enzyme is considered to be a drug target in AD research. Gamma-secretase is the high molecular weight complex composed of at least four essential, integral membrane proteins including presenilin, Nicastrin, Aph-1 and Pen-2.It is particularly important to study the structure-function relationship of gamma-secretase from biological, enzymatical and pathological perspectives. Direct analysis of the structure is difficult because handling such hydrophobic complex in cell and membrane free conditions is extremely problematic. In this project, we plan to take advantage of the camel antibody as a tool for the structural analysis of gamma-secretase. Camel antibodies consist of only heavy chains with highly stable variable regions.The variable region fragment (called nanobody) can be easily expressed as a recombinant protein maintaining specificity and stability. We will immunize camel against the gamma-secretase compex, generate a phage display library of nanobodies, and then screen gamma-secretase binders/inhibitors. Analyses of the obtained inhibitors will provide information about the import ant domains of the gamma-secretase complex. The inhibitors can be applied in a multitude of applications. We will focus on the structural analysis of gamma-secretase, and on cell biological studies. Since these nanobodies can be engineered with modifications that allow t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EUropean test bed for the maritime Common Information Sharing Environment in the 2020 perspective' to be submitted under Seventh Framework.

assistant: **Abstract**

EU CISE 2020 is an important step towards the accomplishment of the European roadmap for CISE; the project attains the widest possible experimental environment of innovative and collaborative processes between European maritime institutions.EU CISE 2020 takes as reference a broad spectrum of factors in the field of European Integrated Maritime Surveillance, arising from the European legal framework, as well as from studies, pilot and R&D projects accomplished in the last three years; in particular, the project is based on:• the CISE Roadmap developed by DG MARE• the results of European pilot projects BluemassMed and MARSUNO,• the work performed by CISE TAG-Technical Advisory Group,• the European studies on maritime surveillance already carried out,• the results of Security research projects in progress, with particular reference to PERSEUS and SEABILLA• the needs of innovation expressed by the maritime stakeholders arising from their operational experience in managing maritime surveillance processes and systems at European, international and national levels.Under the guidance of a Stakeholder Board, EU CISE 2020 will manage in parallel the elaboration of the action plan for the operational validation of new elements of R&D needed to develop CISE (concepts of architecture, concepts of operation, standards of data and services, new services, new processes, ...), the development of an open European test bed for incremental advancement of CISE in the medium-long term, the independent Verification & Validation of the new elements of R&D, as well as the assessment of organizational instruments necessary to sustain the appropriate governance structure and to stimulate public-private cooperation.EU CISE 2020 draws a major space of opportunity for national and European maritime
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Develop tools that use genetic data to better classify complex human diseases', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Many common diseases are highly heterogeneous, meaning that two individuals can be diagnosed with the same disease but have very different progressions or respond very differently to the same medication. These heterogeneous diseases affect a sizeable proportion of the population. For example, approximately one in four people will develop a heterogeneous brain disorder (e.g., a neurological condition such as epilepsy or Parkinson’s Disease, or a psychiatric condition such as depression or schizophrenia)To effectively treat a patient with a heterogeneous disease, it is necessary to quickly and accurately identify their subtype. At present, patient subtypes are decided using only clinical observations, and the process is highly suboptimal. For example, the available subtypes are often incomplete or poorly-defined, meaning that many patients are wrongly classified or can not be classified at all.Previous research indicates that for many heterogeneous diseases, the classification of patients can be improved by incorporating genetic information. However, for this to become a reality, requires statistical tools that do not yet exist. My project will develop novel statistical tools for classifying heterogeneous diseases based on genetic information.My project will prioritize classification of two heterogeneous diseases: epilepsy and schizophrenia. However, I will ensure that my new tools are general, freely available and easy-to-use, so that other groups can construct classification models for many other diseases. Overall, my project has the potential to revolutionize how patients with heterogeneous diseases are treated, and to facilitate more widespread use of precision medicine.


**Keywords:** Statistical genetics, GWAS, complex diseases, personalized medicine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Stimulate Sustainable Freight Transport Systems with Latin American countries' under Seventh Framework.

assistant: **Concept**

The primary aim of the proposed project ENABLE is to contribute to the external relations of EU with Latin American countries, specifically Argentina and Brazil, in the area of co-modal and intermodal freight transport.  The project will stimulate sustainable freight transport systems with Latin American countries.In order to achieve this aim, the work plan of ENABLE entails inventories and surveys to obtain a sound picture of the situation of intermodal freight transport in Latin America; state-of-the-art reviews in Europe that will allow the identification of strengths and innovations of the European freight transport industry and research; and concrete roadmaps to facilitate their effective transfer to the target areas.Special attention will be paid to networking and partnership building actions that will strengthen the dialogue between Europe and Latin America, and foster international cooperation between the two geographical areas. A stakeholders Forum will be established in Latin America. Furthermore, Forum sessions, conferences and other dissemination actions will contribute to the visibility of the project results and engage the stakeholders of both sides in a fruitful dialogue.The partners of the project comprise a team that covers all disciplines that are essential and necessary for the successful implementation of the work plan. The two Latin American partners have a deep knowledge about the intermodal freight transport activities in their countries and the greater region, and they will play the role of agents in the knowledge transfer activities. The European partners are three of the most active organizations in the continent’s intermodal freight transport activities. The consortium will be assisted by the European Intermodal Association (EIA) by engaging i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanisms of stem cell potency in arthritis' (MSCPA), addressing dissemination and exploitation.

assistant: **Impact**

Adult mesenchymal stem cells (MSCs) contribute to maintenance of connective tissues and regeneration of tissues damaged in disease. MSCs are depleted and functionally altered in osteoarthritis. However, the contribution of this stem cell deficit on the etiology of osteoarthritis is unknown.The purpose of this research is to examine the role that MSCs play in the development of degenerative joint disease and the underlying mechanism of altered MSC differentiation in OA will be a central focus of the proposal. This proposal will elucidate mechanisms of stem cell differentiation both in vivo and in vitro and will have a significant impact in defining the role of stem cells in osteoarthritis and in particular on the contribution of a stem cell deficit function to disease progression.In addition this research will contribute significantly to elucidation of the mechanisms the therapeutic efficacy of stem cells in osteoarthritis. This research will break new ground in osteoarthritis and stem cell research and may ultimately lead to the design and development of novel therapies for not only this disease but also allow the development of therapies for other diseases.The funds requested in this proposal will be used to facilitate re-integration of an EU citizen who has trained and worked in the US for over 14 years and has recently moved to take up a position in the newly established Regenerative Medicine Institute (REMEDI) at NUI Galway in Ireland.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dissemination of performance testing methods for ICT-based safety functions in road vehicles' in the context of a Seventh Framework call.

assistant: **Objectives**

The development of road vehicles during the past decade has led to vehicles with improved passive safety. Systems of airbags, seat belts and protective structures have increased safety for the drivers, passengers and lately also pedestrians. Testing programmes for assessment of these passive safety measures have been established.  ICT-based safety functions (active safety") such as electronic stability control (ESC) and lane departure warning (LDW) have been introduced. The largest future improvements of road safety are expected to rely on such safety functions with the aim to prevent accidents from happening. The ICT-based functions are under rapid development and there is presently no generally accepted assessment programme in place. Several research and development initiatives are currently running both on European and national level within the member states of the European Union. Examples of European research projects are the eVALUE project and the ASSESS project . There are also ongoing initiatives within EuroNCAP on an assessment programme for ICT-based safety. The greening of the transport system will result in lighter road vehicles, which will emphasize the requirement for ICT-based safety functions to prevent vehicles from crashing. User awareness has to be raised on the benefits on ICT-based safety functions. The ActiveTest initiative has the objective to disseminate performance testing methods for ICT-based safety functions in road vehicles by: demonstrating performance testing of ICT-based safety functions, disseminating the test programme developed in the eVALUE research project, establishing an active dialogue with key stakeholder groups, compiling an overview of the state-of-the-art and an outlook for future research need, contacting standardisation organ