RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Self Management for large-scale distributed systems based on structured overlay Networks and components' under Sixth Framework.

assistant: **Concept**

The goal of SELFMAN is to make large-scale distributed applications that are self managing, by combining the strong points of component models and structured overlay networks. One of the key obstacles to deploying large-scale applications running on networks such as the Internet is the issue of management. Currently many specialized personnel are needed to keep large Internet applications running. SELFMAN will contribute to removing this obstacle, and thus enable the development of many more Internet applications. In the context of SELFMAN, we define self management along four axes: self configuration (systems configure themselves according to high-level management policies), self healing (systems automatically handle faults and repair them), self tuning (systems continuously monitor their performance and adjust their behaviour to optimize resource usage and meet service level agreements), and self protection (systems protect themselves against security attacks). SELFMAN will provide self management by combining a component model with a structured overlay network.The component model will support dynamic configuration, the ability of part of the system to reconfigure other parts at run-time, which is the key property that underlies the self-management abilities. Basing the system on a structured overlay network enables SELFMAN to extend the abilities of the component model to large-scale distributed systems. In contrast to peer-to-peer file-sharing applications, structured overlay networks provide guarantees for efficient communication and reorganization in case of failures. Combining this with the component model, SELFMAN will build high-level self-management properties on top of these low-level properties. SELFMAN will do both foundational research and applied research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A coherent Raman lensless endoscope for in vivo deep brain imaging of demyelination related diseases in mice models' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The coherent Raman endoscope (CORAE) project aims to develop a lensless endoscope for label-free in vivo deep brain imaging. In particular, the scope of the project is studying demyelination-related diseases in animal models. Myelin sheaths, lipid-rich membranes that surround the axons, are essential for speed and efficiency of propagation of electric signals in the central neuronal system (CNS). The degradation of myelin, i.e. demyelination, can lead to neurodegenerative disorders, such as multiple sclerosis. Understanding myelin dynamics in the CNS is essential to advancing both basic neuroscience and therapeutic approaches. However, current imaging techniques have been constrained by limited penetration depth and invasive procedures, preventing the study of myelin dynamics in its natural environment over time.I propose a novel solution using a multi-core fiber (MCF)-based lensless endoscope (LLEs). In LLEs, the endoscope size reduces to the size of the optical fiber itself (around 150 micrometers diameter), giving access to the deep brain with minimal disruption to surrounding tissue.  The MCF design allows the use of long and flexible fibers, ensuring ease of operation of the endoscope. By using coherent anti-Stokes Raman scattering (CARS) imaging, this endoscope will enable label-free visualization of myelin sheaths in vivo and study their dynamics over time. The CORAE project will focus on studying mice with induced experimental autoimmune encephalomyelitis - the most widely used model for multiple sclerosis research - investigating both the demyelination processes and potential therapeutic interventions aimed at promoting myelin repair. The ability to image live, awake animals over extended periods will provide unprecedented insights into disease progression and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Explore the potentialities of biostealth coatings for tissue engineering and reconstructive medicine'.

assistant: **Innovation**

BioStealth production of implant coatings provides an exciting business opportunity. BioStealth offers unique advantages of societal and economic importance, such as public health and sick leave. Biocompatible materials, i.e. materials with proper cell response upon implantation, are attractive for restoring body function. Conventional implant coating methods lack in quality and therefore the majority, if not all, bio-coatings fail in proper interaction with host tissue, either caused by absence of biological triggers, biofouling or unwanted chemistry. This lack of proper interaction occurs fast upon implantation and disturbs specific cell interaction, eventually causing infections. Mostly, patients need rehospitalization which increase health care costs.BioStealth produces easy and cheap implant coatings by dipping or spraying lipids. BioStealth lipid coatings are air-stable and suitable for in-vivo use. BioStealth can be applied to FDA approved implant materials without changing the mechanical properties, which is key for tissue engineering and reconstructive medicine. BioStealth coatings have a tunable composition which makes them an ideal coating to improve interactions with cells. These factors greatly enhance application potential. Non-fouling lipids were suggested before, but as hydrogels are used for preconditioning implants, air-stability, fast procedures, tunable capability and the range of materials that can be coated and used in-vivo is very limited. In BioStealth innovative, robust conditioning of implants with plasma is used for lipid attachment, creating a breakthrough in integration of implants with tissue. A business case will be developed for BioStealth, covering different markets and routes for market introduction. Results of market analysis and finan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A new life for people with severe disabling cluster headache: Neuromodulation therapy using safe, minimally-invasive simultaneous stimulation at the front and back of the head.' to be submitted under Horizon Europe.

assistant: **Abstract**

Chronic cluster headache and chronic migraine pose a significant challenge for patients and neurologists worldwide. Approx. 48-64% of the patients experience only limited relief from drug-based treatments, they are drug-refractory. Salvia BioElectronics B.V. developed PRIMUS, an innovative peripheral nerve modulator to treat exactly these refractory chronic neurovascular headache patients. The ground-breaking dual-site stimulation targets both the front and back of the head. In ongoing first-in-human studies, PRIMUS has demonstrated a 98.5% effectiveness in reducing the frequency of the debilitating headache attacks (100% patient response rate). PRIMUS advanced design, with a lead of only 0.1 mm and no large implanted battery, significantly mitigates the risks of systemic side effects (0% device-related events reported). This in contrast to existing and competitive neuromodulation devices that are incompatible with the intricate anatomy of the head, placing a heavy and stigmatising burden on patients with severe device-related adverse events such as skin erosion and lead displacement.Using EIC support, Salvia will fund the clinical pivotal trial, regulatory approval and go-to-market for refractory chronic cluster headache. This strategic approach aims to prioritise the severe, yet comparatively rare, cluster headache indication while simultaneously maintaining a strong commitment to the much larger chronic migraine market worth 109B and heavily supported by our investors. By leveraging the positive outcomes for refractory chronic cluster headache, Salvia aims to convince the key partners, neurologists, to facilitate an expedited market access and penetration, in particular for the large refractory chronic migraine market segment. As such, reaching the full commercial po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Medical microbots to support new assisted reproduction techniques' (MicroRepro) targeting Horizon 2020.

assistant: **Abstract**

Infertility is a health issue with sociological and psychological implications that affects approximately 50 million couples worldwide and therefore receives global attention. Among fertility issues, male infertility is diagnosed in about 40% of all cases and the major causes are poor motility of spermatozoa (asthenospermia), low sperm count (oligospermia), abnormal sperm morphology (teratospermia) and/or combinations of these, leading to their inability to fertilize an oocyte. Such problems have been mainly addressed by artificial insemination (AI) and in vitro fertilization (IVF). AI involves introducing sperms into a woman’s uterus with a medical instrument, but its applicability is limited and its success rate is below 30%. In contrast, IVF and intracytoplasmic sperm injection can be more effective but implicate more invasive procedures such as removing oocytes from a woman’s ovaries, fertilize them outside of the body and then transfer the embryos back to the uterus a few days later. These difficulties demand rethinking of assisted fertilization and the sought after novel approaches that offer more natural procedures with high success rate. Hence, we propose untethered medical microbots to assist sperm cells to fertilize an oocyte in living organisms (mice model). The MicroRepro project will bring advances in areas such as bioimaging, nanomaterials science and fundamental biology, boosting the whole field of medical microbots in the process, as was recently highlighted by the PI in an extended comment [Nature 545, 406(2017)]. The PI has decisively contributed to the field of microrobotics and invented the sperm-robot (Spermbot) concept together with his team in two previous patent applications and several publications. The mere concept has attracted worldwide atten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Up-Scaled Production of Graphene Reinforced Thermosetting Polymers for Composite, Coating and Adhesive Applications' (PolyGraph).

assistant: **Concept**

The concept of PolyGraph is to develop new production techniques which will deliver industrial-scale quantities of graphene-reinforced thermosetting polymers, suitable for use in a number of key applications where improvements are needed in the strength, stiffness, toughness, electrical conductivity and thermal properties; such as fibre-reinforced composite resins, coatings and adhesives.The ultimate aim of PolyGraph is to develop a process in which graphene can be produced and dispersed “in-situ” within thermosetting polymer resins, using relatively inexpensive expanded graphite as a starting material.We propose a staged approach to reach this ambitious goal, starting with production of graphene via new chemical and mechano-chemical methods and its subsequent dispersion in thermosetting resins. We will then further develop and modify existing mixing and dispersion equipment to enable the exfoliation of expanded graphite to be carried out directly in thermosetting resins. A further aim is to optimise techniques for the production of fibre-reinforced composites, adhesives and coatings, to ensure that the graphene remains well distributed in the final part.As a result, we will significantly lower the overall cost of these materials and make them viable for use in the composites, coatings and adhesives industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identifying the Capabilities and Limitations of CRISPR in Targeting G-quadruplex Forming Sequences: From Target Recognition to Gene Expression Regulation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated proteins (Cas) have recently been at the forefront of genomic research due to their enormous potential at editing the genome with great precision and specificity. A world-wide effort is currently underway to test Cas proteins and their variants for applications geared towards genome editing for human cells. How CRISPR-Cas systems perform in editing sequences that form non-canonical DNA or RNA secondary structures or are in the vicinity of such structures is the problem we wish to pursue during the course of proposed studies. One such structure is the G-quadruplex (GQ), which has been demonstrated to form throughout the human genome, with particular concentration in telomeric sites, promoters, and 3’ and 5’ untranslated regions of RNA. The higher frequency of potentially GQ forming sequences (PQS) at such regulatory sites has suggested a potential role for these structures in transcription or translation level gene expression regulation. GQ formation has been demonstrated to inhibit gene expression for a number of different genes, including certain critical oncogenes. Inability to remove these structures is directly associated with several syndromes, including Bloom and Werner syndromes, and neurological disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Therefore, editing such sequences to prevent GQ formation also has therapeutic potential. We will design different single guide RNA constructs and target the GQ forming G-rich or the complementary C-rich strand to elucidate the capabilities and limitations of the CRISPR-Cas9 system in editing such structures using single molecule techniques and bulk assays. We will then investigate whether CRISPR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Host-targeted Approaches for the Prevention and the treatment of Hospital-Acquired Pneumonia' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

“HAP2” aims to develop stratified host-directed drugs and biomarkers to enhance the prevention and the treatment of hospital-acquired pneumonia (HAP) and develop precision medicine in infectious diseases. HAP is an infectious disease of major concern in the world, and the most frequent cause of hospital-acquired infections with 500,000 episodes being treated every year in Europe. Despite the development of European recommendations, the incidence remains high, with dramatic medical consequences: existing therapies and preventive measures do not result in the expected favourable outcome (clinical cure and survival) for 30% of patients. HAP are moreover the main cause of antibiotic consumption in European hospitals and are increasingly induced by drug-resistant pathogens. New, alternative and more effective host-targeted strategies are therefore urgently needed to fight antibiotic resistance. The ambition of “HAP2” is to revolutionize the management of HAP: capitalising on the novel concept of critical-illness related immunosuppression altering the host-pathogens interactions, we propose a complete reappraisal of the physiopathology of HAP based on the concept of respiratory dysbiosis. “The HAP2” project will reach two ground-breaking objectives in the field of bacterial infections: first the development of host-targeted approaches for the prevention and the treatment of a severe bacterial infection through the supplementation of the IL-12/IFN-γ axis which is defective in patients at risk of pneumonia; second the development of a clinico-biological score based on an integrative assessment of the host-pathogen interactions and genetic variation, to predict the course of HAP and the response to treatment. Our interdisciplinary consortium, bringing together 10 partners from a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Calibrating and Improving Mechanistic models of Biodiversity' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Mechanistic community models have been advocated as a response to the conceptual and practical limitations of correlative approaches to modeling biodiversity. Building from ecological theory, there are multiple frameworks that could potentially act as a basis for such mechanistic models. However, these options often include a the large number of demographic rates to estimate in species-rich ecosystems, and their direct connection to empirical data has often been limited to simplified settings, something that strongly limits their use for ambitious biodiversity-modeling projects. With CLIMB, we propose an innovative statistical methodology to overcome this challenge: we will connect community data with functional trait data in an array of carefully designed mechanistic community models. More precisely, CLIMB aims to propose and test adequate transfer function(s) that allowrapid calibration of mechanistic models with available trait data and make these models suitable for reliable biodiversity predictions. The CLIMB framework will be developed and tested with simulations and two empirical study cases of temporal dynamics of grassland plant communities dynamics in two different biomes. CLIMB consists in an outgoing phase focused on (1) studying the theoretical fundations of the framework and developing appropriate mechanistic community models; and (2) collecting functional data for local grassland plant species. The return phase will focus on (3) completing the development of the modelling framework and (4) analyzing empirical data.Ultimately, CLIMB will answer pressing fundamental questions of ecology and biodiversity modelling and will offer the ground-breaking perspectives necessary to meet key environmental challenges faced by society today.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cultural influences on leadership in Europe' under Sixth Framework.

assistant: **Concept**

The central aim of this project is to investigate the role of national and organisational cultures on leadership in organisations. A set of studies will investigate the differences in the use of leadership in relation to different industry types and compare these with countries outside the EU. Additionally, the relation between leadership styles and key team and organisational processes is explored.The effects of actual leader behaviours on different outcomes, such a team processes and organisational performance, are important to the financial and social welfare of organisations and individuals. Yet, little is known about actual leader behaviours, as perceived by their direct reports. Leadership is at the heart of studying organisational behaviour and human resources management. Phenomena such as technological advances and globalisation have caused contact between culturally diverse people to increase.This means that aspects such as norms, values, and language affect the interaction, thus making conflicts m ore complex and more time consuming to resolve. Trends measured over decades indicate that managers spend almost half of their time resolving conflicts (Thomas & Schmidt, 1976; Watson & Hoffman, 1996). Thus far, very few comparisons between European organisations have explored the predictive validity of cultural values in terms of conflict management behaviour and leadership.By exploring and comparing European data, insight will be gained in terms of the universal validity of theories and empirical findings, culturally specific solutions will be identified, and recommendations for practitioners can be made.In sum, focus will be on the use of different leadership styles (directive, supportive, and coaching), moderated by culture and industry type. Secondly, the relati