RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Efficient exploitation of EU perlite resources for the development of a new generation of innovative and high added value micro-perlite based materials for  Chemical, Construction and Manufacturing' (EXPERL) under Seventh Framework.

assistant: **Objectives**

Among the various industrial minerals needed by the EU industry, perlite is highly important both from technological and economic point of view with many applications in Construction (ceiling tiles; mortars, as loose-fill insulation), Chemical industry (cryogenics, filter media for chemicals, food products, water purification) and in horticultural applications.   Conventionally expanded perlite has a number of favourable properties (inert, fire resistant and incombustible, good sound and thermal insulation) but is also characterised by low strength, lack of durability, high porosity and easy deterioration that limit the range of its applications and affect the quality of conventional perlite based products. These unfavourable properties originate from the sponge-like open structure of expanded perlite granules, which results from the technology of the expansion process. However, with the application of innovative expansion techniques (indirect heating, microwave) it is possible to produce micro-sized perlite particles with spherical shape and closed structure (CSP), which have all the favourable properties of the conventionally expanded ones and also enhanced mechanical (strength, durability) and physical properties ( porosity, thermal conductivity).  The objective of this proposal is the production of micro-sized closed structure perlite with the application of breakthrough perlite expansion technologies and the development of a new generation high added value end- products based on CSP, including preformed insulating products (panels,  boards and bricks), mortars and functional fillers tailored for the Construction, Manufacturing and Chemical industry  The new CSP-based end-products will present a good number of favourable properties as they will be  lightweight, iner
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Supramolecular Cell Manipulation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Supramolecular chemistry and nanofabrication methods provide excellent prospect to construct reversible dynamic biological nanoplatforms employed for supramolecular cell manipulation (SUMOMAN) experiments. Making use of supramolecular chemistry is a rewarding task in developing functional materials and devices. Knowing the limitations involved in ordering proteins at different length scales will surely hasten the development of future applications, supramolecular nanobiology being the most prominent. The construction of synthetic supramolecular assemblies of proteins provides an excellent tool to fabricate organized bioactive components in the sub-micron regime at surfaces. Supramolecular nanobiology narrows the gap between chemical biology and bionanotechnology. The latter devises ways to construct molecular devices using biomacromolecules and it attempts to build molecular machines utilizing concepts seen in nature. In chemical biology new synthesis methods and strategies are developed and employed for the synthesis of compounds which are used as probes for the study of biological phenomena. Steadily improved synthetic procedures for site-specific modification of proteins have gained more control over structure and function of the proteins. However, applications of protein chips remain hampered by orientational and conformational aspects at the surface.With the development of supramolecular bioactive nano-platforms on surfaces serving as a reversible dynamic interface to cells, the goal to study and manipulate cellular processes will come closer.An innovative construction process of biological nanoarrays is proposed to study important fundamental aspects of cell biology. When such structured surfaces display a biological interface with nm resolution, a lengthscale inh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Next generation methods to preserve farm animal biodiversity by optimizing present and future breeding options' (NEXTGEN) targeting Seventh Framework.

assistant: **Abstract**

NEXTGEN proposes the bold step of using whole genome data to develop and optimise conservation genetic management of livestock diversity for the foreseeable future. The rationale for choosing whole genome data is to ‘future-proof’ DNA-based analysis in livestock conservation against upcoming changes in technology and analysis. Thus, in the context of whole genome data availability, our global objective is to develop cost-effective optimized methodologies for preserving farm-animal biodiversity, using cattle, sheep, and goats as model species. More specifically, NEXTGEN will: - produce whole genome data in selected populations; - develop the necessary bioinformatics approaches, taking advantage of the 1000 human genomes project, and focusing on the identification of genomic regions under recent selection (adaptive / neutral variation); - develop the methods for optimizing breeding and biobanking, taking into account both neutral and adaptive variations; - develop innovative biobanking methods based on freeze-dried nuclei; - provide guidelines for studying disease resistance and genome/environment relationships in a spatial context; - assess the value of wild ancestors and breeds from domestication centres as genetic resources; - assess the performance of a surrogate marker system compared with whole genome sequence data for preserving biodiversity; - provide efficient training and a wide dissemination of the improved methodologies. The consortium has been designed to specifically reach these objectives, and encompasses skills in conservation genetics, bioinformatics, biobanking and breeding technologies, GIScience. The work plan has been established with great care. The sequencing task has been postponed to year 3 to take advantage of cost dynamics, while the two first y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Safety critical knowledge-based decision support systems'.

assistant: **Concept**

What is the research question? The main aim of this project is to develop techniques for ensuring the safe operation of Knowledge-Based Decision Support Systems (KBS/DSS) in contexts where such safe operation is critical for their functioning. These techniques will be taken from existing technologies in both areas (Knowledge-Based Decision Support and safety-critical engineering). The result will be directly applied in a significant safety-critical application in the domain of cancer treatment protocol management. How will we answer the question 1. Exploit existing techniques from safety-engineering, in particular a specific decision-making model (DOMINO -Das et al., 1995-), and a technique for dealing with upforeseeable hazards based on the notion of safety axioms (Hammond et al., 1994). 2. Integrate these techniques in an established KBS development method (Schreiber et al., 1993) 3. Use the results of 1-2 to build an application in a safety-critical domain (cancer treatment protocol management). Concluding : Funding this project is useful because: - it will greatly improve practical usefulness of existing methods for building KBS/DSS - it will extend the scope of existing methods for engineering safety-critical system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Parkinson disease susceptibility gene mutations in Drosophila melanogaster and the therapeutic potential of transgenes alternative oxidase and alternative NADH dehydrogenase' in the context of a Seventh Framework call.

assistant: **Objectives**

Mutations in human genes parkin and DJ-1 cause susceptibility to Parkinson's disease (PD). Both genes have functions linking them to mitochondria and oxidative stress. Parkin protein is a ubiqutin E3 ligase which targets damaged proteins for proteasomal degradation and it has also been shown to localize to dysfunctional mitochondria. Protein DJ-1 has functions as a ROS scavenger and a gene expression regulator of other stress genes. My research uses Drosophila melanogaster lines with mutations in the genes parkin and DJ-1β, which are homologous to the human PD susceptibility genes. These mutant lines have characterized phenotypes displaying both locomotory defect and decreased resistance to oxidative stress. The alternative oxidase (AOX) is a gene commonly found in many plants and fungi but absent in most animals, it provides a by-pass to mitochondrial complexes III and IV. The alternative NADH dehydrogenase (NDI1) is a Saccaromyces Cerevisiae enzyme that provides by-pass the mitodhoncrial complex I. We have seen that the expression of AOX and NDI1, also at high levels, is well tolerated by the Drosophila melanogaster . We also have data demonstrating that the AOX and NDI1 proteins localize to mitochondria and that they provide resistance againts ETC inhibitors, thus making them mitochondrial antioxidants. The aim of the proposed research project is to study the pathogenesis of DJ-1β and parkin mutations in Drosophila. For this purpose I will be using in vivo fly models and primary neuron cultures isolated from the mutant and/or transgenic flies. The mitochondrial and cytosolic reactive oxygen species ( ROS) levels increased by low levels of ETC inhibitors, and my endeavor is to examine how the increased ROS levels affect the pathogenesis of parkin and DJ-1β mutations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The analysis of compact supernova remnants -csnr - and their impact on star formation regions and active galactic nuclei - agn' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content In the past few years there has been growing evidence for the existence of a new sub-class of type II supernovae, whose features suggest the presence of strongly radiative shocks, produced during the interaction of a fast ejecta with a dense circumstellar medium. However, up to now, there is very little information that allows us to verify and to constrain the theories about strongly radiative shocks. Also, crucial to this research project, is the issue of whether the CSNR are indeed a key element in the activity of AGN (as responsible for the emission of broad lines). Detailed knowledge of these peculiar supernova remnants will provide (i) constraints on theoretical models of fast, radiative shocks, (ii) enable the tracing of the formation and evolution of very massive stars, and (iii) substantiate evidence for the Starburst model for AGN. For the last point, it is essential to study CSNR and to establish their observational properties in detail, as well as to probe sources that have both a starburst and AGN activity. Leiden Observatory is one of the best places to pursue this research plane as there are strong groups of experts working on radio-active galaxies (Miley), on evolution of galaxies (Franx), the structure of galactic nuclei (de Zeew), and on star formation processes (van Dishoeck and van der Werf). Training content (objective, benefit and expected impact) The experience I will obtain working in the Observatory at Leiden will allow me to have a broad knowledge of radiative shocks, CSNR, AGN and starburst phenomenon. I will also improve my capability to supervise students (I will be expected to help in the supervision of the students at Leiden University). All of this research and academic experience will be of great value on m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'States of Need / States of Emergency: Towards a Political Grammar of Exigency' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

NOT is a critical study of the emergency-discourse of modern European politics. My thesis is that the political preoccupation with states of emergency tends to overlook – with dire consequences – underlying chronic and ostensibly less urgent socio-economic and ecological conditions, or what I call states of need. This structural relation is captured in the ambivalence of the German word 'Not,' which means at once emergency and need. Since the French Revolution, the history of European politics has been defined by an always asymmetrical negotiation of the tension between emergency and need. This asymmetric articulation of political life is perpetuated by habits of speaking about politics, which are in turn rehearsed in literary and historiographical genres for representing the political theater. For this reason, NOT is an exercise in political philology. I analyze the way in which the grammar of modern politics reproduces the myopic, dramatic, subject- and anthropocentric perspective that privileges emergency over need by addressing a diverse archive of literary and theoretical texts from the 18th century to the present. My research historicizes this political grammar with attention to biopolitics, revolutionary rhetoric, political economy and development economics, human rights discourse, and ecological and Anthropocene debates. In doing so my aim is to excavate alternative forms of expression that do justice to the nexus of need/emergency and thereby recover ways to better articulate the political challenges we face today. In the spirit of Horizon 2020, appreciating the place of Europe in the contemporary world involves understanding the complex legacy of emergency/need that continues to inform national and global politics – as the European migrant crisis, the climate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Poly-functionalised organolithiums: new methods for stability determination and synthetic applications', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

A great deal of research has been devoted to the development of highly functionalized chiral organometallic reagents because their reaction with organic electrophiles provide an expeditive access to numerous polyfunctional molecules of interest in natural product synthesis and development of new pharmaceuticals.The stereoselective formation of a new carbon-carbon bond implies the availability of CSp³-hybridized organometallic compounds having a defined configuration. In this sense, alfa-oxy and alfa-aminoor ganolithiums have gained considerably synthetic status due to their configurational stability.This proposal deals with the study of several aspects of the chemistry of more functionalized alfa-oxy and alfa-aminoorganolithiums, in particular compounds possessing a leaving group (RO-, R2N-) beta to the anionic centre, namely, their stability, aggregation states, reactivity and applications in organic synthesis.We propose to establish a scale of relative stabilities of highly basic beta-heterosubstituted alfa -oxy and alfa-aminoorganolithiums by developing some new methods for the determination of their pKs, as well as for the establishment of the nature of their aggregation states in solution.The measurements of pKs will be performed by studying Sn-Li exchange equilibriums.We plan to analyze the aggregation states by DOSY experiments of 1H-NMR, and also perform theoretical DFT calculations. This methodology will allow us to estimate the contribution of the substituent effects, the interaction with the solvent and the nature of the aggregation to the stability and reactivity of these systems.The results obtained will constitute a tool to rationalize and design new stable polyfunctionalized organolitium systems of increased synthetic value, with application in the synthe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimisation of the material safety factor and sensitivity analysis of the key parameters in the structural design of the reinforced recycled aggregate concrete beams' under Horizon Europe.

assistant: **Concept**

The construction industry generates substantial waste and contributes significantly to greenhouse gas emissions. Concrete, as the primary building material, exacerbates these issues, accounting for approximately 9-10% of global CO2 emissions and a substantial portion of construction and demolition waste. To address these challenges, the utilization of recycled aggregate concrete (RAC) has emerged as a promising sustainable alternative.However, the structural behaviour of RACs remains understudied in terms of the influence of recycled aggregate properties on structural scale behaviour. These is crucial to optimise the use of RACs and, at the same time, mitigate the risk of overly conservative design practices that could undermine sustainability benefits.This project aims to contribute to the development of robust design guidelines for RAC elements by combining experimental testing, numerical modelling and advanced AI techniques. By identifying critical parameters influencing RAC's performance and developing robust design guidelines, I aim to accelerate the widespread adoption of sustainable concrete solutions. This project will analyse large datasets to predict structural properties including bond, dowel action, and aggregate interlock, optimize mix designs and identify potential failure modes. This research will contribute to the development of more sustainable and resilient structures while reducing the construction industry's carbon footprint.


**Keywords:** Recycled aggregate concrete, RAC, structural behavior, AI, experimental testing, design codes, sustainability, concrete, construction, environmental impact, waste reduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multiple-site Environment for Testing Systems with Embedded Software', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The testing activity for a complex and sophisticated system having embedded software with an objective of zero default is a major industrial concern. Testing of systems with inter-operating components presents a basic problem: Indeed, it is not sufficient to test each component solely. It is in fact mandatory to test the dynamic behaviour of the whole system, depending upon the components interoperation. This project will deploy a multi-site tele-testing environment (TOPEN) for systems made up of inter-operating components. Mechatronic systems (provided by Ligeron S.A.) and software for on-line monitoring and control (provided by LABEIN) will be used as test scenarios.Objectives:The METSES project is to deploy a multi-site tele-testing environment for systems made up of inter-operating components, TOPEN. METSES, based on environment TOPEN, will be used to define tests at user-level, specifically designed to validate the behaviour of components with embedded software. Objectives are:a) To deploy TOPEN enabling it to be used in industrial projects;b) To develop the methodological baseline for the use of TOPEN to check requirements in a systematic fashion. Its applicability will be mainly at integration and transfer/acceptance phases;c) To test complex systems. Mechatronic systems (e.g. provided by Ligeron S.A.) and software for on-line monitoring and control (provided by LABEIN);d) To propose TOPEN software to clients/customers for full validation.Milestones:Milestone 1 (M-1): Month 5. Characterised by the delivery of two documents on the responsibility of Ligeron S.A.: User requirements and Market Analysis;Milestone 2 (M-2): Month 8. Characterised by the delivery of a report with both case studies, provided by LABEIN and LIGERON;Milestone 3 (M-3): Month 12. Test report a