RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Female Empowerment in Science and Technology Academia'.

assistant: **Objectives**

FESTA is concerned with implementing changes in the working environment of academic researchers, to encourage female researchers to stay and make a career in the academy and to create organizational environments where their competence is valued and fostered. In particular, we address the working environment of researchers in the lower levels of their careers, to make it possible for them to advance to the ranks of highest scientific expertise. The different partner institutions will take actions on some core issues, which have seldom been directly addressed in previous research or implementation, in particular on the level of the daily environment of researchers: formal and informal decision making processes, meeting cultures, PhD supervision, perceptions of excellence in hiring processes and in the work environment, and resistance to equality measures. FESTA partners are geographically diverse and come from universities and research institutions of different sizes and with different histories. The consortium consists of researchers in science and technology, social scientists with a solid background in research on gender in academia, persons with governing and administrative positions on high levels in the institutional hierarchy, and gender equality officers. As gender equality projects are seldom simply transferable from one context to another, FESTA actions will be carefully analyzed in regard to the contextual success and failure factors. FESTA will come out with a variety of measures which research environments in different European contexts can use in addressing core issues in their gender equality work. These will be formulated as toolkits and manuals and disseminated both nationally and on the European level in workshops, conferences and through the different n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Political Elites and Regime Change in the Middle East and North Africa: Accommodation or Exclusion?' (MENA-PERC) targeting Horizon Europe.

assistant: **Abstract**

Whether political elites accommodate or exclude their rivals during regime crises can be a matter of life and death. Following the 2011 uprisings in the Middle East and North Africa (MENA), elite compromise sustained a democratic transition in Tunisia, while elite conflict triggered a coup in Egypt. Tunisia has since seen three democratic elections, while thousands of Egyptians were jailed or killed by the new military regime. Why do elites in some cases pursue accommodation while they push for excluding their rivals in others? MENA-PERC proposes an answer to this puzzle: the degrees of asymmetry and polarization between regime coalitions and their challengers shape elite preferences for accommodation or exclusion. These preferences, in turn, determine the type of regime emerging from crisis. Regime coalitions comprise elites who provide crucial links to social constituencies and whose collective support stabilizes the regime. The project theorizes the role of these actors, linking macrolevel outcomes in terms of regime types to evidence on the microlevel of individual elites. The project draws on evidence on 12 regime spells in three MENA countries across more than a century. Regime coalitions are identified by focusing on members of parliament in Egypt (1882-present), Tunisia (1907-present), and Turkey (1908-present), observing processes of elite change empirically based on individual-level data on these elite members and leveraging these data in a mixed-methods design. Second, the project traces causal mechanism through elite surveys and in-depth fieldwork examining authoritarian consolidation in contemporary Egypt, democratization in Tunisia, and democratic backsliding in Turkey. The project makes three contributions. It theorizes why elites accommodate or exclude d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards a SYstems-Based, holistic Environmental Risk Assessment of Chemicals (SYBERAC)' (SYBERAC) under Horizon Europe.

assistant: **Objectives**

TOWARDS A SYSTEM BASED, HOLISTIC ENVIRONMENTAL RISK ASSESSMENT OF CHEMICALS (SYBERAC)Biodiversity is key to modern society, sustaining natural resources and providing essential ecosystem services. According to the UN Sustainable Development goals, the European Green Deal, the EU Biodiversity strategy and other European and national level Directives and strategic regulations, pollution is one of the main drivers of biodiversity loss. The risks resulting from the use, release and effects of chemical on the environment is addressed in a plethora of EU-level Directives and regulatory strategies, each with specific (chemical) targets and protection aims. There is, however, concern that such a fragmented approach does alleviate the threats of chemicals to biodiversity and ecosystem services. To protect genetic and functional biodiversity from pollution impacts, a paradigm shift is needed. This transformation should move beyond the current fragmented Environmental Risk Assessment (ERA) performed in specific regulatory silos, e.g., Plant Protection Products (PPPs)regulation for pesticides, REACH for industrial chemicals and Biocides framework for Biocidal chemicals, towards a harmonised and systems-based ERA applicable to all chemicals, species and land use functions. To make this advance, SYBERAC will provide ways forward to rationalise the current silo-based Protection Goals into high-level system-based Protection Goals and to operationalise their use within systems-based ERA robust and broadly applicable ERA structures. Six case studies, overarching different silos of current ERA will provide proof-of-concepts of the developed approaches. Based on targeted stakeholder engagement, in close cooperation with other relevant projects on the topic, results and outcomes will be dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of dual-targeting epigenetic modulators for polypharmacology-based cancer therapy' under Horizon Europe.

assistant: **Concept**

Cancer is a multifactorial disorder involving different genetic and epigenetic alterations. Since epigenetic modifications are brought about by multiple enzymes working synergistically, multitargeting compounds may be particularly effective to acutely interfere with aberrant processes. The simultaneous inhibition of two or more enzymes by a single molecule provides improved therapeutic efficacy compared to single-target inhibitors, along with reduced insurgence of drug resistance.Through this project, I aim at developing novel therapeutics targeting protein (de)methylation and (de)acetylation for application in cancer therapy. I will synthesise and evaluate hybrid molecules inhibiting two enzymes at the same time. I will develop two classes of compounds targeting the Lysine-specific histone demethylase 1A (LSD1) and either Protein arginine N-methyltransferase 5 (PRMT5) or Histone deacetylases 1-2 (HDAC1-2). These enzymes cooperate in different pathways that lead to cancer insurgence and progression, hence dual targeting represents a successful strategy to counteract tumour growth.To achieve the outlined aims, I will employ a multidisciplinary approach requiring the fusion of knowledge and tools from medicinal chemistry, biochemistry, biophysics, molecular and cell biology. Through the employment of cutting-edge synthetic approaches, I will prepare LSD1/PRMT5 and LSD1/HDAC1-2 inhibitors which will be assessed through multiple biochemical and biophysical assays. I will also employ native mass spectrometry to investigate their mode of action in the context of the multi-protein complexes formed by the protein targets. The most promising inhibitors will be evaluated in cellular assays to assess their anticancer properties and their effects on transcriptional regulation.This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Study of policies regarding economic instruments complementing transport regulation and the undertaking of physical measures' (SPECTRUM).

assistant: **Concept**

The main objectives of the SPECTRUM proposal are:- to develop a theoretically sound framework for defining combinations of economic instruments, regulatory and physical measures in reaching the broad aims set by transport and other relevant policies- to assess the implications of gradually shifting from a more command-and-control type of approach towards a more market orientated in reaching transport and other policy goals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Role of epigenetic mechanisms in random X chromosome inactivation in vivo.'.

assistant: **Innovation**

Developmental progression is linked to accumulation of epigenetic memory mainly in the form of chemical modifications of the chromatin. However, the dynamics of this process as well as its functional relevance remains unclear. One of the most striking examples of transcriptional regulation by epigenetic processes is random X chromosome inactivation (XCI) in female mammalian embryos, which evolved to compensate between XX and XY individuals. This process is strictly dependent on coating of one X chromosome by a long non-coding RNA, Xist. This process is also associated with rapid and dramatic remodelling of the chromatin resulting in the loss of active epigenetic marks and reciprocal accumulation of repressive ones. The functional relevance and exact specio-temporal dynamics of this process remains elusive. Here I propose to address these questions by using an integrated approach linking in vivo with in vitro experiments as well as population-based and single-cell studies. I will use a proprietary single-cell ChIPseq method and standard ChIPseq assay to assess the dynamics of X chromosome epigenetic inactivation. Further transcriptomic experiments and chromatin accessibility profiling will add additional depth to a dataset accounting to a roadmap for XCI. I aim at identifying the initial stages of epigenetic programming leading to transcriptional repression as well as genomic loci involved in nucleating these changes. I will finally address the functional relevance of X chromosome epigenetic programming by using gene knockout models and genome-wide single cell transcriptomics approach. Such work will have wide-raging implications beyond the field of XCI. By achieving unprecedented level of information on the heterogeneity and dynamics of epigenetic processes this project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Sweet adhesins: Probing bacterial glycoproteins with novel tools to inspire future antibacterial strategies'.

assistant: **Innovation**

With bacteria increasingly resistant to current antibiotics, new strategies to fight infection are needed. Bacterial adhesin proteins, which play an important role in the establishment of infection, appear to be promising targets for novel therapies. Adhesins enable the first contact between bacteria and host cells. We know that some adhesins are modified with highly unique sugars that are important for adhesin stability and adherence. However, we do not know how widespread this modification is, and whether it constitutes a good target for antibacterial strategies. A lack of suitable methods for the detection of bacterial adhesin sugars has impeded the detailed study of these sugars, blocking further efforts to develop antibacterial strategies against bacterial adhesin sugars.  In this project, I aim to revolutionize our understanding of adhesin sugars, in terms of timing and prevalence of the modification, which is crucial information to start targeting adhesin sugars. To this end, I have designed an innovative approach that combines the strengths of carbohydrate chemistry, enzymology, microbiology and molecular dynamics to 1) establish straightforward methods to selectively visualize and quantify the adhesin sugars directly on the surface of bacterial cells; 2) detect the presence of adhesin sugars under changing growth conditions and in relevant clinical isolates; and 3) develop a computational method to predict the presence of sugars on adhesins that have not yet been identified. Recent findings from my team on the process of adhesin modification underscore the uniqueness of adhesin sugars, and this experience puts me in an ideal position to start this project.  The overarching goal of STICKY SUGARS is to lay the foundation for the exploitation of adhesin sugars as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of mathematics in the education of engineers in Barcelona' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content - The general objective is to make a study of the system of engineer education from the point of view of skills and to focus this study on mathematics. - The operative objective is to determine sociological variables which have influence on the way of teaching mathematics in each school: variables attached to the student and variables concerning the scientific departments of every school. - Other objective is to make a qualitative analysis on the teaching of mathematics: lessons, use of equipment and documents, teaching methods, observations of the individual learning methods of a student sample. Training content (objective, benefit and expected impact) I expect to acquire reflexive knowledge on mathematics in engineering, industry and more generally in professional education. Links with industry / industrial relevance (22) This research must allowed to understand better the relationships between fundamental science and technological education. It must enable the industrial managers to control better the links between therecruitment and their own strategies of innovation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of functional food products for space use' (2002-2006).

assistant: **Innovation**

During space missions the human body undergoes extreme stress (e.g. radiation exposure, bone decalcification) that result in significant health hazards that affect also common people and, more significantly, in an aging population. In recent years there ha s been an increasing awareness of the role of food as a tool to improve people's well being and as a mean to prevent and counteract specific pathologies. Specific components of food products have been isolated and proven to have beneficial effect on the body (e.g. high antioxidant content, high calcium availability).This project aims to the development of high quality, convenient, nutritionally dense functional food products (gel based snacks, unleavened-flat breads, lasagna-like entrée). Product composition will be designed to be reach in ingredients with functional properties and will include, among the others, legumes, soy, tomato, carrots, berries, grapes, etc. High Pressure Processing, an innovative stabilization technique, will be used in-addition-to/ instead-of common stabilization techniques and its effect on textural, microbial, nutritional properties of food items and their stability will be evaluated. Food product will be studied with a multi-analytical and multi-disciplinary approach centred on t he physico-chemical characterization of food matrices at macroscopic, structural and molecular levels.This project has a strong interest in basic research that is directly applied to food items and the findings can be directly transferred to practical industrial applications. Collaborations with nutritionists, chemists, microbiologists, technologists in the University of Parma and other Italian and European research institutions will be established to create interdisciplinary research programs. The focus on the cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Building Resilient International Development through Green Employment in the EU and Asia'.

assistant: **Innovation**

The project ‘Building Resilient International Development through Green Employment in the EU and Asia’ (BRIDGE) aims to comprehensively examine the structure and evolution of 'green jobs'—those essential for the green transition—along global value chains, in response to the growing international economic shifts toward sustainable development. The project’s core premise is that the ecological transition transcends national borders, representing a global process. As a result, labor dynamics related to this transition are deeply interconnected across regions worldwide. Asia, particularly China, plays a key role in the development and production of goods and services crucial to the green transition. These processes form a ‘global value chain’ of green jobs and tasks, encompassing every stage from design and planning to raw material extraction, production, logistics, and distribution. The exploration of this ‘global green-employment chain’ (GGEC) is critical for identifying potential areas of collaboration and competition, while also assessing the feasibility of regional development strategies in both the EU and Asia. The project wants to leverage on my expertise on labor economics to develop an analysis on a global level, adopting a multidisciplinary approach, encompassing empirical analysis and qualitative interviews to key actors to develop empirical informed computer simulation experiments (EICSE). The project will be hosted by two top-class academic institutions: the Department of Economics and Management at the University of Parma (UNIPR, Italy), under the supervision of Prof. Fabio Landini, and the School of Management and Economics at the University of Electronic Science and Technology of China (UESTC) in Chengdu, under the supervision of Prof. Daitian Li. This MSCA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Absorbing aerosol layers in a changing climate: aging, lifetime and dynamics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Aerosols (i.e. tiny particles suspended in the air) are regularly transported in huge amounts over long distances impacting air quality, health, weather and climate thousands of kilometers downwind of the source. Aerosols affect the atmospheric radiation budget through scattering and absorption of solar radiation and through their role as cloud/ice nuclei. In particular, light absorption by aerosol particles such as mineral dust and black carbon (BC; thought to be the second strongest contribution to current global warming after CO2) is of fundamental importance from a climate perspective because the presence of absorbing particles (1) contributes to solar radiative forcing, (2) heats absorbing aerosol layers, (3) can evaporate clouds and (4) change atmospheric dynamics.Considering this prominent role of aerosols, vertically-resolved in-situ data on absorbing aerosols are surprisingly scarce and aerosol-dynamic interactions are poorly understood in general. This is, as recognized in the last IPCC report, a serious barrier for taking the accuracy of climate models and predictions to the next level. To overcome this barrier, I propose to investigate aging, lifetime and dynamics of absorbing aerosol layers with a holistic end-to-end approach including laboratory studies, airborne field experiments and numerical model simulations.Building on the internationally recognized results of my aerosol research group and my long-term experience with airborne aerosol measurements, the time seems ripe to systematically bridge the gap between in-situ measurements of aerosol microphysical and optical properties and the assessment of dynamical interactions of absorbing particles with aerosol layer lifetime through model simulations.The outcomes of this project will provide fundamental ne