RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Single molecules in soft matter: dynamical heterogeneity in supercooled liquids and glasses' in the context of a Seventh Framework call.

assistant: **Objectives**

Single-molecule optical microscopy provides average-free, dynamical and structural information about condensed matter at molecular scales. Single fluorescent molecules can now be located and tracked with a spatial resolution as high as a few tens of nanometers, even at depths as large as several microns. These capabilities are ideal to link the macroscopic physical properties of soft condensed matter with the structure, organization and dynamics of the constituent molecules. Perhaps the most surprising conclusion drawn from single-molecule observations is the unsuspected heterogeneity of molecular assemblies, both in time and space, which had remained largely hidden in conventional ensemble experiments. The structural glass transition is said to be one of the hardest open problems in condensed matter science. Although most agree on the crucial part played by heterogeneity in this process, the guesses vary wildly as to the scale and relaxation times of the inhomogeneities. Our recent discovery of glassy rheology in supercooled glass formers, following earlier observations of heterogeneity, has been received with much interest in the complex liquids community. I am convinced that single-molecule studies have the potential to radically change our view of supercooled liquids and glasses. In a broader sense, molecular insight from chemical physics complements the general ideas developed by statistical physicists. I believe it is the missing link toward a molecular control of the physical properties of soft materials. I propose to perform a broad range of novel single-molecule experiments using a micro-rheological cell to apply mechanical stress, strains and/or temperature jumps. In particular, we will perform mechanical studies of solid-solid friction, and temperature-jump s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bio-economic feasibility of intensive culture of pike-perch' (LUCIOPERCA) under Fifth Framework.

assistant: **Objectives**

OBJECTIVES AND EXPECTED ACHIEVEMENTS The overall aim of this project is to assess the technical and economical feasibility of intensive culture of pike-perch. A number of specific objectives can be distinguished: * The market-potential of intensively reared pike-perch will be established for fingerlings (restocking) and consumption-sized fish* The costs of production of fanning pike-perch, using a recirculation system or a flow-through system for production, will be established* The production of pike-perch will be optimised by research on reproduction, fingerling production and ongrowing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ONCOgenic Receptor Network of Excellence and Training' (ONCORNET), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the nex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Actions providing access to DASP technology for digital designing of Microwave and Radio Frequency IST systems' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The Actions for developing/activating services in provision of access to the generic Digital Alias-free Signal Processing (DASP) technology represent the essence of the EURODASP project. DASP is an advanced technology for DSP system design and cost-effective processing of signals digitally in a wide dynamic range and in considerably extended frequency range. This technology is especially attractive for microwave and Radio Frequency designs by replacing analog subsystems by substantially more effective digital ones. For signal frequencies upto 2-3 GHz. EURODASP is aimed at development and activation of an infrastructure for consulting, information dissemination, training, prototyping and small-volume manufacturing services for the European IST Community to the DASP technology. The project covers development of material basis of these services (typical DASP modules, ASICs, documentation, training courseware etc.).Objectives:The basic objective of EURODASP is to open up and provide access to the novel Digital Alias-free Signal Processing (DASP) technology having significant advantages for digital microwave and Radio Frequency designs. The project is aimed at: development and activation of an infrastructure for consulting, information dissemination, training, prototyping and small-volume manufacturing services providing access for the European IST Community to the wideband digitalisation DASP technology including development of the material basis of these services; drawing attention to the potential of this technology by demonstrating the capability of DASP subsystems to solve signal processing problems under conditions where similar classic DSP products are inapplicable; establishing collaboration with at least 12 industrial companies where application of the DASP technolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GEnetics for Healthy Aging', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Europe is the oldest continent and is rapidly aging. The aim of the IP GEHA is to identify genes involved in healthy aging and longevity, allowing individuals to survive to advanced old age in good cognitive and physical function and in the absence of major age-related diseases. To achieve this aim a coherent, tightly integrated program of research that unites demographers, geriatricians geneticists, genetic epidemiologists, molecular biologists, bioinfomaticians and statisticians has been set up. The genetic analysis will be performed by 8 high throughput platforms, within the framework of a centralized database. The working plan of this IP is to: i) collect an unprecedented number (2550) of long-lived (90+) sibpairs from 10 European countries; ii) perform a genome scan by microsatellites in all the sibpairs (a total of 5100 individuals) iii) refine the regions identified by the genome scan by a linkage disequilibrium (LD) mapping using SNPs in cases (i.e. the 2550 probands of the sibpairs) and in 2550 younger controls who will also be recruited, followed by positional cloning and mutational analysis. Three regions in chromosome 4 (D2S1564), 11(11.p15.5) and 19 (around APOE gene) suggested to be involved in aging and longevity in previous studies, will be investigated for their LD block structure in CEPH families and then by an economic number of SNPs in the entire collection of recruited people.All the recruited people will also be genotyped mitochondrial DNA haplogroups and mutations known to play a major role in aging and longevity. Additional advanced approaches (bioinformatics, advanced statistics, mathematical modelling, functional genomics and proteomics, molecular genetics) are envisaged to identify the gene variant(s) of interest. The experimental design will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'reuSable strAtegic space Launcher Technologies & Operations' to be submitted under Horizon Europe.

assistant: **Abstract**

SALTO will perform, for the first time in Europe, fly / recover / refly cycles of a reusable rocket first stage demonstrator. Operating a large-scale vehicle at low altitude, consistent with future European strategic needs, and embedding a set of critical technologies, the project will significantly boost the strategic launchers roadmap, enabling the vision of a future launch fleet improving by 50% space access costs and reducing environmental impacts.  SALTO will hence act as a “stepping stone” towards reusability of strategic launchers in Europe which is one of the key leverages to reach such vision. Fully aligned with previous ESA-funded activities (e.g. Themis initial phase Program), SALTO focuses on - Technologies and building blocks maturation up to TRL5/6 for the first stage of a strategic launcher;-  Subsystem/system tests with two low altitude system tests (“hop test”) campaigns. SALTO's methodology will combine robust system engineering with technology maturation activities and a stepped demonstration strategy to accelerate experimental learning through the implementation of the Agile methodology. The SALTO project will culminate in flight test campaigns to demonstrate and validate the technologies necessary for a reusable launch vehicle.SALTO will contribute to the cost reduction target for strategic launcher in Europe by addressing ~3/4 (in cost) of all technologies / operations involved in a future European reusable rocket stage. While Europe is currently lagging behind other global players when it comes to reusable launchers, SALTO will reinforce EU’s independent capacity to access space, secure autonomy of supply for critical technologies and equipment, and foster EU's space sector competitiveness.At the end of the project, lessons will be drawn regarding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Marine Water Quality Information Services – AquaMar' (AQUAMAR), addressing dissemination and exploitation.

assistant: **Impact**

Water quality (WQ) is a focus of monitoring agencies and the public, and it is subject of several European Directives and regional conventions. The AquaMar project will develop and provide downstream services turning Marine Core Service products into WQ services, demanded by end user. The team is composed mainly of SMEs (70%) supported by key scientific partners. The objective is to create a reference technical and organisational body at European level for WQ services, organised as an open partnership, through: · methodological research extending traditional WQ portfolio along 5 novel product lines · turning these into pre-operational services, including adaptation to MCS · establishing a validation & quality evolution process and data model · evaluate the services with end users through service delivery trials · transferring the developed services to other services providers (SP) through a well defined process (technical and organisational framework). The service portfolio includes (1) indicators for the reporting requirement of the Water Framework Directive and the European Marine Strategy, (2) algal bloom forecasting, (3) support to large scale marine infra., (4) services supporting the Bathing Water directive monitoring, (5) aquaculture precision farming. This is complemented by research on methods for improved standard WQ products, geostatistics, and distribution tech., to be used across the service portfolio. In parallel, a validation and quality evolution strategy is developed and applied, including the services sustainability wrt new space sensors. A user & customer board is steering the project, participating in the trials and providing feedback to the MCS, the validation and research activities. The aim is to prepare the ground for a sustainable continuation a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A calorimeter at atomic resolution', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Molecular interactions are at the basis of all biological processes and often include specific interactions between macromolecules (protein, RNA, DNA) and small-molecule ligands, such as cofactors, hormones, drugs, or metabolites. Detailed and quantitative knowledge of these interactions is critical for a molecular understanding of these biological processes and developing new therapeutic solutions. A complete comprehension of molecular recognition requires a full characterization of the geometry and dynamics of the molecular complex. This includes not only the internal dynamics of each partner but also the dynamics at the interface, which to date remain mostly unexplored experimentally.The physical chemistry frame for studying intra- and inter-molecular interactions is thermodynamics. The extent to which two molecules interact is dictated by the Gibbs energy change (G) of the interactions, which is composed of enthalpic (H) and entropic (S) terms.X-ray crystallographic and NMR structures provide a detailed description of the static interactions associated with enthalpic contributions. However, up to now, the entropic components remain difficult to address experimentally.The overarching goal of this proposal is to develop a calorimeter at atomic resolution.To achieve that goal, a new NMR spectroscopy approach, relying mainly on the nuclear Overhauser effect, will be developed. It is anticipated that quantitative thermodynamic measurements within molecules and molecular complexes will open a new avenue in the fundamental understanding of how atomistic mechanism(s) create a function.Beyond the fundamental findings, we foresee applications in translational medicine, drug design, and computer-assisted molecular design.


**Keywords:** bioNMR spectroscopy, Thermodynamics of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Phenotype switching: plasticity and/or differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate.'.

assistant: **Innovation**

The limited success of cancer therapy especially in advanced metastatic disease warrants a reassessment, especially given our limited understanding of the nature of cancer cells and the factors that allow them to proliferate and metastasise. Stromal cells of the tumour microenvironment, including fibroblasts, endothelial, immune, adipose and mesenchymal cells, significantly affect cancer cell characteristics and tumour fate; however, their sometimes dichotomous function in high- and low-aggressive tumours has not been thoroughly investigated. Here, we propose to elucidate the largely unknown role of haematopoietic stem and/or progenitor cells (HSCs) on tumour growth and metastases. We found that such cells reside in the tumour niche predominantly in non-aggressive tumours. We hypothesise that cancer cells trigger the differentiation of HSCs into haematopoietic tumour-supporting stromal cells, thereby inducing a phenotypic and functional switch that skews them towards a tumour-promoting phenotype, hence promoting tumour cell aggressiveness and metastases. To test our hypothesis, we will use high-throughput technologies to track the lineage, differentiation and commitment of HSCs during tumour progression. Our specific aims are therefore:(a) To systematically analyse tumour-promoting and tumour-restricting stromal phenotypes at the cellular and molecular levels.(b) To characterise stromal cell plasticity and the contribution of tumour cells to the phenotype switch.(c) To determine whether differentiated stromal cells and HSCs in cancer patients can predict clinical outcome.(d) To screen for molecules that inhibit the tumour-promoting stromal switch.Blocking the tumour-promoting phenotypic switch and maintaining a pre-mature tumour-restricting stromal microenvironment repr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improving assessement and management of small pelagic species in the Mediterranean' (SARDONE) under Sixth Framework.

assistant: **Objectives**

The project aims at developing a series of tools which will enable a better understanding, stock assessment and fishery management of small pelagic fish resources (anchovy and sardine) of the Mediterranean. The three major stocks and fisheries i.e. the NW Mediterranean, the Adriatic and the Aegean have been chosen. Investigations will aim at detecting nursery areas, at developing echo-surveys for recruitment strength estimation, at filling the complete gap in knowledge on the ecology of late larvae and juveniles, at improving the selectivity of current fishing gear, at assessing the impact of fry fisheries on the stocks, at exploring the application of novel stock assessment methodologies to Mediterranean small pelagic stocks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Environmental regulation of mine waters in the european union (ERMITE)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Events of the past decade have underlined the sensitivity of many aquatic ecosystems and water resources systems to pollution from mine waste and effluents from active and abandoned mines. The goal of this project is to develop integrated policy guidelines to expedite European legislation and practice in relation to water management in the mining sector.This goal will be achieved by interactively addressing the multiple facets of this problem at two different levels:(i) Integrated analysis of the variety of problems in EU Member States and potential accession states in Eastern Europe.(ii) Integration of insights from disciplines such as law, economics, social policy, engineering and environmental sciences and management. A pan-European multidisciplinary team will work in close connection with end-user departments of the Commission and an extensive network of national and European stakeholders to deliver an integrated set of policy guidelines.