RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identifying Metabolic dysregulation to Guide Novel FOXP-ID/ASD Therapies' (IMAGiN-IT).

assistant: **Concept**

The mechanisms underlying monogenic intellectual disability (ID) and autism spectrum disorder (ASD), affecting >2% of the population, remain poorly understood. Moreover, most ID/ASD syndromes are still untreatable, the exception being some disorders of metabolic origin. Therefore, identifying unappreciated metabolic mechanisms underlying the pathophysiology of ID/ASD provides a promising avenue to treatment.Several lines of evidence suggest that the transcription factors FOXP1/2/4 are ID/ASD genes with such an underappreciated role in brain (energy) metabolism: mitochondrial defects and altered metabolic rate in FOXP animal models, unpublished FoxP-/- brain transcriptome data of my host, and GWAS-based data indicating that FOXP1/2 genes are significantly associated with body mass index in the general population. Therefore, my main aim is to characterize ID/ASD phenotype-relevant metabolic dysregulation in FoxP mutants and ameliorate its effects. Powerful genetic tools in Drosophila allow me to probe specific molecular mechanisms with high spatial and temporal resolution and relate them to clinically relevant phenotypes, including locomotion behaviour habituation learning, and sleep. My objectives are to: 1) Identify phenotype-relevant metabolic target pathways of FoxP, 2) Characterize metabolic dysregulation in FoxP neurons with spatial resolution 3) Reverse behavioural FoxP phenotypes with metabolic or other innovative therapeutic interventions.This interdisciplinary approach further develops the data analyses, molecular, and imaging skills that I acquired through my PhD training and allows me to merge it with unique disease-relevant data, clinical knowledge, and collaborating networks. This project has the potential to provide novel insights into the relation of metab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessment and certification rules for digital architecture' in the context of a Fourth Framework call.

assistant: **Objectives**

The technical issues of the project are:° The definition of the assessment framework and criteria for safety architectures used in the guided public transport industry;° The development of a certification scheme for safety architectures, particularly in the following fields: * numerical assurance approach (coding), * implementation details of check redundant computer systems, * distributed architectures. %The results of the project (safety assessment criteria and certification scheme) will be adopted in the phase of the Validation of ERTMS.Test Paris : MATRA-tranport Napoli : ANSALDO-trasporti %ERTMS project CENELEC TC9X activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Protein Mining of Cereal side-streams Exploring Novel Technological Concepts' (PROMINENT).

assistant: **Innovation**

There is a global need, from sustainability, food security and also health perspective, to increase dietary intake of plant protein. Side-streams from wheat and rice processing offer large under-exploited raw material potential, and we will work throughout the agro-industrial value chain to valorise that. The main aim of PROMINENT is to develop techno-economically and environmentally viable protein-based ingredients and foods from cereal processing side streams. We will concentrate on novel fractionation and extraction technologies, such as bioprocessing, supercritical carbon dioxide (SC-CO2) -extraction, thermo-mechanical technologies, wet and dry fractionation, and expanded bed adsorption as well as their combinations as novel hybrid processing technologies. A strong focus will be in using enzymatic and thermo-mechanical methods to improve techno-functional and sensory properties of protein ingredients to reach desirable taste and texture in food applications. Pasta, biscuit, cake and beverage food models are the main end product categories, where new protein ingredients will be used as dietary protein source and act as performance proteins to deliver similar techno-functional and sensory properties to animal proteins. We will also assess the safety, quality, techno-economical feasibility, sustainability and market potential of the new protein ingredients and foods, and design strategies for marketing, dissemination, and exploitation of innovations. The project will support the economic growth, resource efficiency and sustainability of the European agro-food industry, and open new market opportunities by generating new plant protein ingredients obtained from cereal processing side streams as well as new products for the consumer food market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A Collaboration Ecosystem enabling EU Creative SMEs to exchange multi-media content and create multi-plot, interactive Apps for Children, curated according to Reader ability and educational value.'.

assistant: **Concept**

“Q-Tales” is a Collaboration Ecosystem, specifically designed to serve the needs of the European Children e-book industry, where European Creative SMEs, Experts and Parents, co-create new or transform existing Children Literature into high quality e-books & Apps using innovative ICT solutions provided by European ICT SMEs along with a Curation Framework provided by European Academic experts in the field of Pedagogy, Children Psychology and evolutionary Psychology. The specific objectives of the project are summarized below:• Objective 1: Build the Q-Tales Collaboration Platform and respective ecosystem, including Gamification Aspects, where European self-publishers, authors, illustrators, voice actors, animators and other related SMEs & professionals will find & submit industry news, communicate, offer & receive services and collaborate. • Objective 2: Develop the Q-Tales Authoring Tool, featuring an easy-to-use interface with powerful and sophisticated authoring features which will be used to create the Q-Tales e-books and apps, incorporating the Q-Tales Ontology and utilizing gamification techniques.• Objective 3: Launch the Q-Tales Store where the authored e-books and apps will be offered worldwide. • Objective 4: Define the Technical and Pedagogical Q-Tales Curation Frameworks, in order to ensure that every single item sold is, technically perfect and better connected with current academic developments in the fields of child / evolutionary psychology while offering a scent of “Europeanness”, whilst incorporating nation- and country-specific literacy cultural and linguistic elements. • Objective 5: Develop a new breed of in-app analytics services.• Objective 6: Identify & Connect with established European Children Literature Content Providers and Sources.• Objective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ACTIVATING INCLUSIVE GROWTH IN RAILWAY SMES BY WORKPLACE INNOVATION' under Horizon 2020.

assistant: **Concept**

Railway Industry is complex because of the high added value of the services and supplies that involves the market in itself. Different standards apply to the industry along the whole value chain, with different technical standards, making difficult the digitalization process of the railway industry due to the particularities associated to it.  The main objective of RailActivation Project is to create and piloting a rail business and organisational mechanisms for the uptake of workplace innovation by SMEs from the railway sector as part of an Open Innovation ecosystem. To this end, the RailActivation project will work on the development of a new mechanisms and tools based on proven principles to anticipate the effects of the digitalisation on the railway sector and designing innovation process transformation for the EU Railway Industry from the inside out by actively reimagining the entire business around the customer, enabling employees to be the catalyst for change. In order to address this objective, the specific objectives of the project are: (i) Looking at existing tools, identify and exchange best practices, (ii) Suggest a new pilot scheme, including context based, long term mechanisms to support the uptake of workplace innovation by the SMEs, (iii) test pilot scheme, (iv) create an interregional network, (v) raise awareness and dissemination of the need for Workplace Innovation, and (vi)Workplace Innovation recommendations of the benefits of these innovations. The RailActivation will be the first business model adapted to its use in the rail industry and turn every worked into a committed worker through the uptake of workplace innovation by SMEs; thus, enabling inclusive growth in railway SMEs.


**Keywords:** Open Innovation, workplace innovation , working smarte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Investigating the role of Neuroligin-4 in the development of autism-related synaptic and behavioral abnormalities in mice' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Autism is a frequent neurodevelopmental disorder, characterized by impairments in social interaction, language deficits, and repetitive behaviors. The biological basis of autism remains unknown, and no cure or effective pharmacological treatment is currently available. Given the high prevalence of autism and the devastating consequences for patients and families, it is essential to improve our understanding of the molecular mechanisms underlying autism and to identify potential therapeutic approaches.According to an important new concept that has arisen over recent years, autism may be a ‘synaptopathy’, i.e. a disorder resulting from an aberrant development and function of synaptic connections in the brain. In support of this hypothesis, autism-related mutations have recently been identified in a number of proteins that play an essential role at synapses. In particular, several different mutations in the synaptic adhesion molecule Neuroligin-4 (NL-4) have been linked to autism, making this one of the most frequent monogenic causes of non-syndromic autism known to date. However, little is known about the molecular mechanisms by which NL-4 affects synapse development, or how loss of function of NL-4 may lead to the cognitive and behavioral impairments characteristic of autism.Here, we propose to address this issue by investigating the effects of constitutive and inducible manipulations of the NL-4 gene in mice, using a combination of molecular, physiological, and behavioral techniques. This approach will allow for a detailed characterization of the role of NL-4 in synapse formation and maintenance. This, in turn, will enable us to elucidate the relationship between NL-4-induced synaptic abnormalities and autism-related behaviors. Our study will greatly contribute to the u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The first non-toxic bio-based polymer resin to revolutionize the wood panel industry' in the context of a Horizon 2020 call.

assistant: **Objectives**

Across huge industries, like the construction and wood industry, formaldehyde-based polymer resins are used in large volumes as binders to keep together materials and components to produce stable and durable products. Such oil-based based resins, however, pose a large societal and environmental burden, as these are toxic, carcinogenic, non-recyclable, and have a large CO2 footprint. Due to increased problem recognition and recently introduced regulations, these industries actively seek for alternatives. However no safe, bio-based and cost-competitive resins are currently available that meet the functional requirements for a strong and durable material,.. until now. Plantics B.V. has developed Plantics-GX, a strong, 100% bio-based, recyclable and safe (no formaldehyde or other toxic components) alternative with a carbon footprint that is 5 to 7 times lower compared to existing resins. Plantics-GX is a biopolymer of which the raw materials are abundantly available, at low cost, making production of Plantics-GX cost-competitive to existing oil-based resins. It is ready to replace toxic and polluting resins, starting with binders in the wood industry. The SWOP consortium, consisting of 3 industrial parties and 1 NGO, has been established to realize and accelerate market entry of revolutionary GX-wood panels with Plantics-GX used as a binder. As a result of this project, these wood panels will be commercialized by Koskisen Oy, Finnish market leading wood manufacturer, and used by Triboo B.V., Dutch circular furniture manufacturer, to commercialize formaldehyde-free kitchens. WOOD.BE, a Belgian research and advice organisation in the wood industry, will perform studies to measure the health and environmental effects of a shift to using Plantics-GX. This two year project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A novel technology for sewerage mapping, inspection and cleaning with integrated real-time self-audit capability' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Sewage systems are crucial to reduce the risks of water borne diseases and avoid flooding of cities. Cleaning processes are thus highly important to avoid health risks and environmental, economic and societal impacts which can be caused by damaged or blocked sewerage. European sewage networks are operated by over 20,000 municipalities and public entities which spend over €6.5 billion annually to clean and maintain over 2.25 million km of pipes that are constantly deteriorating. Over 10,000 SMEs are employed by network operators to keep the sewerage clean and operable. Recent budget cuts and the implementation of the water framework directive (2000/60 EC) that requires new measures for more efficient use of water resources have put pressure on municipalities and therefore on the service providing SMEs in the cleaning business in order to save water resources and find cheaper ways of maintaining efficient sewage networks. Current systems for sewer cleaning are highly inefficient. During the cleaning process, high amounts of water are used to clean the pipes regardless of the real cleaning demands. Hence, there is a high need to develop a system integrating a reliable inspection tool which efficiently varies the cleaning process according to the real demand. The PIPEGUARD system will consist of an ultrasonic inspection system, which will detect the degree of pollution and damages. The data captured will be used to adjust the cleaning through algorithms. After cleaning, the system will keep a record that will provide a reliable cleaning audit trail. Further, PIPEGUARD will monitor with inertial sensors the system position in real-time in order to obtain reliable position mapping for the creation of network maps. The solution will not only cut costs for cities due to the use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Cyclic Arylenevinylene Polymers'.

assistant: **Innovation**

Research work at the University of Manchester (UNIMAN) has developed an efficient synthetic method to prepare arylenevinylene polymers with control of molecular weight and end-group functionality by the ring-opening metathesis polymerization (ROMP) of strained 1,9-cyclophanedienes.  The CyclAr project will use this methodology to deliver conjugated polymers of novel topologies, including rings, 8-shapes, trefoils and others. Macromolecular rings will be prepared by ring expansion metathesis polymerization (REMP) using a tethered ruthenium carbene complex and more complex topologies from telechelic polymers prepared from a bifunctional ruthenium carbene complex. Electron rich (p-type) and electron poor (n-type) polymer topologies will be prepared from the appropriate functionalised cyclophanedienes and topological heterojunctions examined. These molecules will be screened for their photovoltaic performance as the novel molecular topologies can lead to an enhanced charge separation and fewer loss mechanisms - key factors in achieving higher power conversion efficiency in OPVs. The synthetic methodology to be adopted is novel and application of these topological arylenevinylene polymers as semiconducting materials in device fabrication is unprecedented.The overall aim of the project is to develop novel topologies for arylenevinylene polymers and to investigate the influence of the molecular shape on the physical, optical and electronic properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Array of sensors for long term seabed monitoring of geohazards' (ASSEM).

assistant: **Innovation**

Understanding the slopes instability phenomena or tectonically active areas requires the capacity to measure and monitor a set of geotechnical, geodesic and chemical parameters. Although this monitoring can be achieved on shore with conventional means, its implementation on subsea areas presents numerous difficulties. The project proposes to develop and evaluate an instrumentation set enabling this monitoring, on subsea areas of about 1 km2 during up to two years. It comprises a part devoted to improving and adapting a selection of sensors to their particular implementation conditions, a part dedicated to the networking of the sensors organized in a set of distributed subsea stations for data collection. The developed system will be implemented in the Ormen Lange oil field and Gulf of Corinth, selected for the important consequences of geohazard risks on the local population and industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Network to promote grazing and to support grazing-based farms on their economic and ecologic performances as well as on animal welfare' to be submitted under Horizon Europe.

assistant: **Abstract**

Grazing-based production systems have the proven potential to produce high quality food, to be beneficial to the competitiveness of farmers and animal welfare, as well as for other ecosystem services and are widely apreciated by the society. However, for many reasons grazing is generally declining in Europe, which is a threat for many ecosystem services. In Grazing4AgroEcology (G4AE), grazing farmers are for the first time at the centre of a thematic network, complementing other thematic networks such as Inno4Grass, EuroDairy, SheepNet, BovINE, HNVLink, etc. in providing solutions for sustainable, integrated grazing-based animal production systems. G4AE has 18 partners including farmers organisations, extension services, education, and research in eight countries (France, Germany, Ireland, Italy, The Netherlands, Portugal, Romania, & Sweden). The  Partner Farm Network of G4AE of 120 Partner farms (15 per country) will enable the capture and implementation of best-practices and innovations to promote grazing for agroecology. Our 3-tier multi-actor approach based on co-creation and knowledge sharing will actively involve all relevant actors of the grazing AKIS including farmers, industry, education, researchers, advisors, society, etc. This will improve the uptake of the innovation capital and significantly contribute to the improvement of the transferability of best practices and innovations and will also enable cross linkage of OGs. G4AE will innovate the grazing sector by strengthening the capacity of farmers to understand more objectively their own agroecological performance through an integrated self-assessment. This will trigger farmers to strive for innovation. G4AE will boost digitalization through webinars, digital interactions, videos and media training. G4AE wi