RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'How vertically transmitted gut microbes and immune genes synergistically direct anti-malarial defence in birds' to be submitted under Horizon Europe.

assistant: **Abstract**

Mounting an appropriate and effective immune response is critical to protect an organism from infection. In vertebrates, the adaptive immune system (AIS) plays a central role in immunity, and evidence is accumulating that its development is governed by intricate crosstalk between host immune genes and gut bacteria (GB). This implies that specific synergisms exist between bacterial taxa and AIS, mainly encoded by the highly polymorphic Major Histocompatibility Complex genes (MHCs), to promote optimal immunity. However, the specific associations between GB and MHCs in defence against parasites and their potential effects across generations are poorly resolved in one of the largest vertebrate classes: the birds. BornThisWay will close major gaps in our current understanding of immune consequences of GB-MHC crosstalk in wild birds using two ideal study populations. The action will capitalise on my and my host’s (Prof. Helena Westerdahl) extensive backgrounds in avian gut microbiomes and avian adaptive immunity, respectively. BornThisWay will i) establish how GB and MHC act in concert to defend against avian malaria parasites, ii) determine if synergistically optimal protection is transferred across generations, and iii) test immune consequences of GB-MHC crosstalk disruptions. BornThisWay will add a new dimension to host-pathogen interactions in wild birds, generate novel fundamental insights into the adaptive significance of GB-MHC crosstalk, and provide transformative insights of conceptual and empirical value to transgenerational immunity in vertebrates.


**Keywords:** Birds, Gut microbiomes, Malaria infections, MHCs, Transgenerational immune priming
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-Functional Detective System (MFDS) – Advanced, ‘Intelligent Transport System’ creating smarter and safer European roads' to be submitted under Horizon 2020.

assistant: **Abstract**

Wilhelm Schröder GmbH has developed the ‘Multi-Functional Detection System’ (MFDS), a highly versatile ‘Intelligent Transport System’ that will make EU roads better integrated, safer, intelligent and environmentally friendly. MFDS is a unique, affordable and unrestricted telematics technology with several functions: wrong-way driver detection, traffic congestion detection, vehicle counting by vehicle classification and parking accounting. The core innovation of the MFDS is its capability to complete all functions simultaneously in a single system that is low-cost to procure and install with low-power usage.An MFDS unit consists of a detection of 6 delineators (pillars) that distributes a secure radio field across the target path; objects within the field are passively detected and classified with 100% precision. Data obtained is immediately communicated to motorists via an LED lighting interface built into the delineators as well as being securely provided via cloud to the relevant officials via system interfaces to warn motorists in a wider perimeter with other means.With our initial target market in the EU, during Phase 1 and Phase 2 we plan to market to road operators in target countries with the intention to generate pre-sales that will enable our target volume sales once Phase 3 is reached in 2020. Once commercialised, we plan for 6,500+ unit sets to be deployed by 2024.The principle project objective is to enhance MFDS and demonstrate to the target market the efficiency and environmental improvements our technology offers over state-of-the-art alternatives. This Feasibility Study will allow us to complete a market study and use customer feedback to develop the project concept; identify strategic Phase 2 collaborators; scope the legislative pathway; plan the techni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Assessment of Policy Impacts on Sustainability in Europe' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The EU has formulated ambitious environmental policy targets in a variety of sectors aimed at forming the basis for a sustainable European growth with increasing prosperity and reduced pressure on natural resources and the environment. The overall motivation of the APRAISE (Assessment of Policy Interrelationships and Impact on Sustainability in Europe) project is to improve the decision basis for EU and national policy makers for selecting an efficient environmental policy mix leading to the transition towards a sustainable European society, including appropriate support for environmental investments. APRAISE aims to provide an improved understanding of the efficiency, effectiveness and efficacy of environmental policies impacts and their interactions at both the European and Member State level by taking into consideration the social, environmental and economic dimensions of sustainable development. Furthermore, APRAISE will offer guidance on ex-ante policy impact assessment and come up with general policy recommendations. APRAISE will therefore assist policymakers in reducing inefficiencies in policy design and to create win-win situations whereby economic strength goes hand in hand with environmental protection and efficient use of natural resources.The strategy of APRAISE is to combine an empirical data collection and assessment component with model-based policy scenario analysis in order to achieve a synergetic use of a variety of empirical and model-based impact assessment tools using different sources of data. The empirical component consists of ex-post assessments of policy effects, costs and social implications as well as on an improved systems understanding including interactions between different policies. In addition, the effects of environmental policies on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Agricultural Research for Improving Arable Crop Competitiveness', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

EUROCROP aims at setting up a network putting together all stakeholders, to organize a collective research needs analysis to improving the European arable crops competitiveness, and to propose research actions. EUROCROP partnership as represented by the st akeholder board, includes organisations using research, including farmers organizations, as well as organisations providing research, innovation and extension services. Representative organizations of civil society in the field of environment preservation and consumer advocate will be integrated in the partnership at the beginning of the project. To meet its goals EUROCROP will operate according to a cross-cutting approach, first by arable crop (cereals, oilseeds, sugar beets, fibre crops, potatoes, grain l egumes and maize), second by transversal elements of the competitiveness including technical aspects at farming level, farm economics and production costs, outlets and markets, quality of agricultural products, environmental impacts and socio-economic issu es. These topics will be addressed by specialists, in the frame of workshops, according to a common method. The main results of this two and a half years concerted action will be (i) a set of research proposals for policy makers and planers, strengthened i n the course of a final conference opened to a broader audience and (ii) the existence of a European network of specialists, which would continue to work beyond the end of the action to set up research projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Accelerated Development of multiple-stress tolerAnt PoTato' (ADAPT).

assistant: **Innovation**

ADAPT identifies molecular mechanisms of adaptation to combined stress in potato to develop new strategies for the improvement of productivity, yield stability and product quality under multiple stress conditions. Potato is one of the most important food crops worldwide and a major constraint to secure yield is its sensitivity to environmental stresses, particularly heat and drought, which is often followed by flooding in the field. Whilst limited knowledge of combined stress signalling pathways is available in model plants such as Arabidopsis, this knowledge is almost completely lacking in crops. These adaptation mechanisms require metabolic reprogramming that is triggered by different signalling pathways. To understand the dynamics of complex signalling and response mechanisms our approach will utilise several technological advances (for example high throughput phenotyping and novel sensor plants). These tools will guide us to the key developmental stages and tissues for in depth analysis allowing unprecedented dissection of these processes. The approach requires complementary expertise from 10 leading academic research institutions with 4 major potato breeders, and a screening technology developer. This unique combination of molecular biology, stress physiology, systems biology and analytics with engineering and molecular breeding as well as the active participation of end-user driven agencies for variety testing and potato trading ensure translation of ADAPT results. Arising from our mechanistic understanding, our expected results will include new breeding targets and the potential to match potato varieties to specific environmental conditions. Knowledge from our research will directly reach the most relevant stakeholders and end-users feeding into breeding programm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy and emissions thresholds for providing decent living standards to all' (DecentLivingEnergy) targeting Horizon 2020.

assistant: **Abstract**

There is confusion surrounding how poverty eradication will contribute to climate change. This is due to knowledge gaps related to the material basis of poverty, and the relationship between energy and human development.  Addressing this issue rigorously requires bridging gaps between global justice, economics, energy systems analysis, and industrial ecology, and applying this knowledge to projections of anthropogenic greenhouse gases. This project will develop a body of knowledge that quantifies the energy needs and related climate change impacts for providing decent living standards to all. The research will address three questions: which goods and services, and with what characteristics, constitute ‘decent living standards’? What energy resources are required to provide these goods and services in different countries, and what impact will this energy use have on climate change? How do the constituents of decent living and their energy needs evolve as countries develop? The first task will operationalize basic needs views of human development and advance their empirical validity by discerning characteristics of basic goods in household consumption patterns. The second will quantify the energy needs (and climate-related emissions) for decent living constituents and reveal their dependence on culture, climate, technology, and other contextual conditions in countries. This will be done using lifecycle analysis and input-output analysis, and mapping energy to climate change using state-of-the-art energy-economy integrated assessment modelling tools for 5 emerging economies that face the challenges of eradicating poverty and mitigating climate change.  The third task will shed light on path dependencies and trends in the evolution of basic goods and their energy intensity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AN INNOVATIVE BUSINESS MODEL FOR A USER–CENTRIC DECISION SUPPORT SYSTEM TO INCREASE AND SUPPORT ELECTRIC VEHICLES UPTAKE' to be submitted under Horizon 2020.

assistant: **Abstract**

The main objective of this innovation project is to refine, scale up and bring to market readiness a user-centric ICT decision support system (CleanPEA) that makes use of an innovate four-tier business model involving corporate fleet owners, vehicle drivers, EV manufacturers and infrastructure providers. CleanPEA will purpose it to support and encourage corporate fleet owners/operators to make the change from diesel-/petrol-powered, Light Commercial Vehicles (LCV – cars and vans) to the Electric Vehicles (EVs) equivalent. This will help the EU meet its demanding CO2 emission reduction targets, as cars and vans contribute around 15% of all CO2 emissions across Europe . Fleet Innovations Ltd. (FLEET) is an ambitious, Innovative-Driven Enterprise (IDE) with a strong desire to internationalise their business and led by a team of experts and serial entrepreneurs in providing data capture/reporting technology systems and fleet management solutions to track corporate business mileage/journey data. While engaging in customer building activities for our current solution (PEAK Miles), we discovered a strong desire among commercial corporations with company LCV fleets to switch to EVs as a way of cutting their cost and meeting their carbon reduction obligations . Europe’s corporate fleets produce around 380Mt CO2 emission annually, accounting for around 8% of all EU emissions . We have conservatively estimated that the successful commercialisation of CleanPEA will allow us to generate new cumulative revenues and profits respectively of €94.32m and €57.55m (EBITDA) 6 years post project (2022). As a result, we would create 91 new jobs across Europe and directly contribute to the reduction of CO2 emissions by 609,780 tonnes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CharactERizing the neuronal Effects of BehavioRAL-modifying proteins from the zombie FUNGI, Ophiocordyceps, using C. elegans', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Ophiocordyceps unilateralis is a species complex of entomopathogens known for their ability to manipulate the behavior of infected ants (zombie ants). While these behavioral effects are well described, the molecular basis for behavioral manipulation is still being explored. During my current postdoctoral fellowship with the National Science Foundation USA, I have identified a set of putative behavioral effectors and am currently utilizing the model organism yeast to express these biomolecules and test their behavioral effects in ants. This proposal will build on my previous work by utilizing another model organism, C. elegans, to analyze the transferability of these effectors to other animal models and to understand their effect on core neurological pathways. To accomplish this goal, I will collaborate with the Van den Heuvel lab at Utrecht University, a developmental biology team known for their excellence in the imaging of nematodes. Their access to a pre-established C. elegans Yeast-Two-Hybrid library and experience with the genetic modification of nematodes will be paramount in addressing three research objectives set for this project: identifying the biological targets of behavior-modifying effectors using Yeast-Two-Hybrid mating, analyzing the behavioral effects of these effectors via transgenic expression in C. elegans, and evaluating tissue-specific changes at the molecular level in C. elegans using mass spec. Such a project spans many biological subdisciplines, and thus, lends itself well to the international exchange of personnel, advanced training, and ideas, allowing me to make use of my experience with molecular cloning and acquire new skills handling and observing C. elegans. Furthermore, the study of Ophiocordyceps effectors present an innovative approach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Development of an innovative aircraft deicing system'.

assistant: **Objectives**

In winter, ice build-up on aircrafts waiting for take-off is a serious safety concern. De-icing fluids are used to remove frozen precipitation, such as snow or ice from the aircraft wings, tail, rudder, landing gear, and fuselage. Aircraft de-icing fluids (ADF), as applied, are a mixture of about 50 weight %water and 50% Glycol that is pressure sprayed at temperatures up to 70°Cin order to melt and wash office. An airport such as Frankfurt spends up to 300.000 Euro for ADF per day. Another very important economic aspect is the time required for the de-icing operation since a time-efficient de-icing is vital for keeping a flight time schedule. By developing a new innovative deicing system it will be possible to avoid the adverse effects associated with aircraft de-icing operations and to improve the safety of the working environment with significant economic and environmental benefits.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Carbohydrate Mimesis using Fluorinated Sugars for Chemical Biology: From Reaction Design to Applications in Molecular Imaging' in the context of a Seventh Framework call.

assistant: **Objectives**

The principle objective of this proposal is to validate fluorinated glyco-structures as effective carbohydrate mimics for the next frontier in pharmaceutical research. Herein we propose to capitalise on the major advances in statistical data analysis which are unravelling the complexity of mammalian and bacterial “glycospace”. Molecular mimicry is a powerful drug design approach. It is therefore envisaged to develop a focussed programme of research to validate fluorinated glycostructures, and in particular 2-fluoro sugars, as carbohydrate mimics for chemical biology, exploiting the ubiquitous role of carbohydrates in molecular recognition. Salient features of the 2-fluoro substituent include (i) enhanced hydrolytic stability to enzymatic degradation, (ii) the presence of a NMR active reporter nucleus (19F) for facile analysis, and (iii) the possibility for molecular imaging application when using 18F labelled glycostructures. Phase one of this project will aim to develop synthetic routes to the target fluoro-glycostructures. This will involve a substantial component of physical organic chemistry including conformational analysis, advanced 19F NMR spectroscopy and the possible isolation of oxo-carbenium analogues by exploiting advances in the development of large, weakly co-ordinating anions. From first principle reaction design and development, through a basic understanding of conformation and reactivity, phase 2 will focus on the application of these materials for chemical biology applications. Phase 2 will then heavily focus on the application of complex oligosaccharides containing the PET active 18F moiety. It is envisaged that by exploiting the ubiquitous role of carbohydrates in molecular recognition that this would conceivably lead to the development of selective