RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of the 91 kda tfiiic subunit in class iii genes transcription' (1994-1998).

assistant: **Concept**

The primary event in gene transcription is the recognition of promoter sequences by transcription factors. One particularly interesting case is the binding of yeast transcription factor TFIIIC (z or tau) to tRNA genes. The elucidation of the molecular structure of X and the identification of the polypeptides that contact DNA are prerequisites to our understanding of the mechanism of tRNA gene activation. We have made some observations that hint at an important role for the 91 kDa subunit of TFIIIC (X91 ) in class III gene expression: It is the only TFIIIC subunit that can bind a nucleic acid on its own and there is a possible link between the transcription and RNA maturation processes (I have observed a strong RNA maturation defect in a z138 mutant that was suppressed in a n138+T91 double mutant). My research project aims at strengthening these observations and at establishing the role of T91 in TFIIIC. I shall first confirm that T91 iS part of TauB, the TFIIIC domain that binds to the B block of tRNA genes and has a predominant role in stabilizing T-DNA complex, then focus on the interactions engaged by T91 at the DNA, RNA or protein level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The validation of alternative methods - ecvam' (1998-2002).

assistant: **Innovation**

Specific ObjectivesGeneral- publication of a comprehensive review on the use of alternative test methods and testing strategies in relation to the Future EU Chemicals Policy;- organisation of a conference to review the current status of alternative methods and future prospects for their development, validation, acceptance and application;- publication of a report on Good Cell Culture Practice;- continuation of the ECVAM PECO project on the Three Rs and advanced testing methods and their validation;- participation in the 4th World Congress on Alternatives and Animal Use in the Life Sciences, to be held in New Orleans, USA, in August 2002- further establishment and integration of expertise in analytical chemistry and in molecular biology;- completion of a number of major external study contracts.Task 1: Validation- publication of an ESAC statement on the scientific validity of the GM-CFU assay for acute neutropenia;- publication of an ESAC statement on in vitro tests for percutaneous absorption;- publication of an ESAC statement on acute systemic toxicity testing;- publication of an ESAC statement on the target animal safety test (TEST);- publication of an ESAC statement on physicochemical methods for the potency testing of recombinant follicle stimulating hormone ( rFSH );- follow-up of the pre-validation study on skin irritation, initially with a preliminary blind trial with refined protocols, followed by a validation study;- initiation of a pre/validation study on the neutral red release assay;- initiation of a validation study on computer models for predicting pharmacotoxicological endpoints;- initiation of a pre/validation study on biocompatibility testing of dental filling materials.Task 2: Acute and Systemic Toxicity- setting-up of a validation study with ICCVAM on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unlocking production-speed additive manufacturing at the micro-scale'.

assistant: **Innovation**

Photosynthetic B.V., founded in 2018 in Amsterdam, revolutionises microfabrication with its ultra-fast 3D printing technology, producing micro- and nano-structures with feature sizes under a micron. Awarded the Formnext Start-Up Challenge, Photosynthetic aims to lead the next generation of microfabrication, significantly impacting health and other sectors. Our mission is to revolutionise microfabrication by enabling efficient industrial-scale production of microstructures, unlocking new product possibilities, especially in health.We plan to set the standard for manufacturing nano- and micro-structures, starting with microfluidic devices like micro-porous membranes for cell analysis, Microneedle Array Patches (MAPs) for drug delivery or bio-scaffolds for tissue engineering.Current microfabrication methods are slow, expensive, and limited in complexity. Photosynthetic’s Volumetric Micro-Lithography (VML) technology overcomes these challenges, enabling rapid production of complex 3D geometries with sub-micron precision. VML is based on single-photon polymerization, and is 1000 times faster than Two-Photon Lithography (TPL). It forms entire objects simultaneously, offering high resolution and speed.Photosynthetic’s technology addresses needs in biotechnology (micro-porous membranes), pharmaceuticals (MAPs for vaccine delivery), cosmetics (microneedles for drug delivery), public health (mass immunisation), or research (custom scaffolds). Revenue comes from printer sales and printing services. We promote green manufacturing through reduction of the material usage, and shortening of time-to-market. The technology enhances Europe’s technological independence and creates high-value jobs.We are seeking €2.5 million in EIC grant funding and €6 million equity (€3 mln EIC + €3 mln o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'XR2ESILIENCE'.

assistant: **Innovation**

The health care system is in crisis and although the importance of nurses' mental health is widely recognized, achieving this goal is highly challenging. Promoting resilience in times of crisis appears to be a promising goal for public mental health. Innovative digital technologies to enhance resilience might contribute to a solution. Extended reality (XR) applications are highly immersive, interactive, and attractive to use. The proposed project aims to leverage the potential of XR to promote resilience in nursing staff. As resilience has a multitude of facets a prospective cohort study together with new analysis of existing large datasets will inform about those resilience factors that are the most promising target for interventions in nurses. Likewise, barriers and facilitators of acceptance of resilience training in general and XR-supported interventions in particular will be extensively considered and researched within this project. As acceptance through participation is a key success factor, a XR-supported training to foster resilience will be developed in close cooperation with nurses and other stakeholders. The proposed XR2ESILIENCE solution consists of a flexible selection of XR modules that can be customised to meet individual nurse needs. The efficacy of XR2ESILIENCE on stress coping and resilience will be investigated in a randomised controlled trial including a health economic evaluation. In addition, the project will go beyond the individual perspective and consider organisational and structural challenges. The cohort study will enable to identify working environments where nurses can grow and enfold their resilience. Based on the results, will develop a set of recommendations and checklists for employers and policymakers  that support them in making nursi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Portable, accessible and sustainable magnetic resonance', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

MRI is a key modality in clinical care, with well over 150 million scans performed annually for diagnosis and treatment monitoring. Its major strengths are multi-contrast and the lack of ionizing radiation. However, its Achilles-heel is cost: typically millions of euros to purchase, site, and maintain, and also requires highly skilled technicians. As a result, MRI is available only in larger hospitals in the developed world, and unlike other imaging modalities plays little role in population screening. In the developing world, MRI systems are far too expensive and complex to purchase and maintain, and over 70% of the world’s population has zero access to MRI, which could be critical in treating diseases such as hydrocephalus, stroke, head trauma and viral infections. The aims of PASMAR are to develop new low-field MRI systems which will enable a role in medical screening in the developed world, as well as providing an affordable, sustainable and accessible platform for the developing world. The major thrust of PASMAR is methodological, designing new types of low-cost low-field systems for specific clinical applications, and optimizing all aspects of system performance to overcome the challenge of much lower MRI signal. I aim to develop, in consultation with clinical colleagues locally and via ongoing collaborations with engineers and clinicians in Africa, specialized systems which can be used for adult/pediatric brain, orthopedics and lung/spine scanning, as well as new types of inexpensive handheld ultra-lightweight surface scanners. These take advantage of the enormous flexibility of designing permanent magnet arrays with completely new geometries, targeted for specific organs. I will focus on portability to maximize patient reach and minimize siting requirements, acc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Socio-economic and geographic variations in health: methods for quantifying and explaining health needs and small area variations in risk' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives: - To develop state-of-the-art methods and software based on Bayesian statistics for the analysis of small area variations in health;  - To use the methods and software developed to quantify the extent to which socio-economic, geographic and other factors may explain small area variations in health in different European settings;  - To quantify the impact of errors in data recording and coding on estimates of disease occurrence and small area variations in health needs, and to develop methods which account for these during analysisBrief description:Planning the delivery of health care takes many forms in the different member states of the European Union. However, a common requirement is for adequate, timely and accurate information on the health needs of populations to facilitate health service provision in an efficient, effective and equitable manner. By necessity, estimation of such information must be done at local level, to match the delivery of health care. Unfortunately there are formidable technical barriers to overcome in the assembly and correct analysis of such 'small area' data. This Concerted Action aims to make these analyses feasible for people working in the public health field by developing guidelines for the assembly of health data and assessment of data quality, and by developing and disseminating methods and software for their analysis. In particular, the project will involve an assessment of the completeness and quality of various small area datasets available to each of the participating partners, and the implications for analysis and interpretation. The project will also address the technical difficulties associated with geographic inconsistencies in the data (e.g. due to measurements being available at different spatial scales), spatial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Collection and quantification of pharmaceuticals from biological samples using capillary electrophoresis'.

assistant: **Concept**

Capillary electrophoretic (CE) methods are increasingly finding applications within the area of pharmaceutical analysis. CE allows to carry out high performance analysis and, what is more important, in a fast, cheap and clean way. However, an important drawback of CE is its problematic application to both quantitative and micropreparative analysis of compounds real samples. The work presented in this project will be focused on the application of CE for quantitafication and collection of pharmaceuticals from biological samples. Thus, special attention will be paid to several parameters which can affect both the reproducibility of the quantitative analysis and the production ratio (i.e. quantity of collected analyte divided by time). These parameters include: capillary geometry and its dimensions, separation voltage, injected quantity and buffer choice, the use of standards (internal, external, standard addition) and the influence of the matrix's complexity. Next, the occurrence of pharmaceuticals in biological samples and their degradation and/or pharmacokinetic will be quantitatively monitored and the fractions of interest will be collected. Samples will obtained from the Clinic Hospital in Valladolid and from Glaxo S.A. (Aranda de Duero, Burgos, Spain). Results expected can provide some valuable guidelines about CE as quantitative and micropreparative technique and on its application for determination and collection of pharmaceuticals from biological samples. These guidelines would help to establish CE as a primary technique in analytical laboratories. Also, they could be directly extrapolated to other areas where analytes use to occur in very complex matrixes (such as foods, environmental samples, beverages, etc). Moreover, these results could show the potential of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Future propulsion and integration: towards a hybrid-electric 50-seat regional aircraft' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

FUTPRINT50 addresses the need to accelerate disruptive technologies in aviation to ensure Carbon Neutral growth commitment from FlightPath2050. It will develop tools, technologies and aircraft level analysis for key hybrid-electric technologies supporting the entry into service of a 50 seat class aircraft by 2035/2040. This type is at the locus of convergence of timeframe and technology, promising to open with improved costs new routes for point 2 point connection of smaller, interior cities and villages at lower infrastructure costs than rail or road transportation, fulfilling aviation’s higher goal of connecting people for the creation of wealth and societal good. FUTPRINT50 will focus on energy storage, energy harvesting and thermal management. Besides advancing the state of the art of these technologies, it will research and develop MDO design methodologies whilst considering uncertainty, models and tools to evaluate new configurations and integration at system and aircraft level. To attain the ambitious vision of an entry into service aircraft by 2035/2040, FUTPRINT50 will develop roadmaps to align future research on technology development but also the regulatory side, striving for market, technology and legal readiness for entry into service. For this FUTPRINT50 will use research developed within the project but also extend itself to other complementary projects and initiatives, besides engaging the main stakeholders in comprehensive workshops. Furthermore, open-source aircraft design tools, hybrid-electric aircraft designs, and reference data sets will be generated and shared openly with the community to accelerate the development of future hybrid-electric aircraft. Finally, FUTPRINT50 will be developed by an international consortium of diverse and highly compete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Palaeolithic Plant Use in the Western Mediterranean'.

assistant: **Concept**

This project deals with one of the big gaps of knowledge in prehistory, how plant foods and resources were used by preagrarian societies. Plants have been fundamental for human societies across the planet. However, it is a blank when it comes to archaeological evidence of humans eating and exploiting them during most part of Prehistory. This work aims at changing the meat/hunting centred paradigm of Palaeolithic subsistence by readdressing human plant exploitation through a novel interdisciplinary approach. The main objectives are: 1) To assess wild plant exploitation among Palaeolithic-Epipalaeolithic societies, 2) To appraise resilience and change in Palaeolithic-Epipalaeolithic plant use, and 3) To improve archaeological methodology and fieldwork. The chronology of analysis –from the Late Middle Palaeolithic to the Epipalaeolithic- includes two extremely interesting periods: a) the transition from the middle to the upper Palaeolithic with neanderthal extinction and early presence of modern humans which gives us the opportunity to explore and compare whether these groups exploit plant resources in a different way, and b) the climatic change from the Late Pleistocene to the early Holocene which allows to evaluate how last hunter-gatherers from the region adapt to climatic change and new ecological conditions. The challenge of the work is to obtain archaeological visibility of plant use through and interdisciplinary approach that combines: pollen analysis, the study of plant macroremains including underground storage organs (USOs), micromorphology, analysis of microremains such as phytoliths and starch, ethnobotany and use-wear analyses on tools. The different types of evidence to be analysed come from relevant archaeological sites from Spain, Portugal and Morocco. Beca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Prosocial Motivation and creativity in work, career, society: Researching the role of prosocial & autonomous motivation for creatively resilient and innovative behavior in different work contexts' (MUSES) under Horizon 2020.

assistant: **Objectives**

Interdisciplinary research shows that our lineage survived while all other human species went extinct because our ancestors used their creative capacity to reshape the threats and opportunities of their environments, in turn reshaping themselves. As our world and working environments become increasingly dynamic, uncertain, and knowledge based, organizations and social challenges depend on creative ideas and creative resilience from employees, young people and entrepreneurs. As Teressa Amabile posits “only by using multiple lenses simultaneously, looking across levels, and thinking about creativity systematically, will we be able to unlock and use its secrets. What we need now….is to tie together and make sense of the diversity of perspectives found in the literature – from the innermost neurological level to the outermost cultural level”. A growing body of empirical work suggests that giving to others and perceiving that we, as humans, have positive impact though our work is beneficial for own resilience, well-being and creative nature (Martela & Ryan, 2016, Eshel et al., 2017). MUSES is aiming to moving away from the cognitive-behavioral dichotomy and by adopting a more systemic approach focus on the rewarding/motivational effect of perceived social impact and aims at capturing patterns of proactive & creatively resilient behavior of different samples where rewards are not absolutely institutionalized and thus are of lower importance whereas motivation is the key & dominant element. Thus, MUSE aims to research the relationship between prosocial & autonomous motivation (perceived social impact & affective commitment to the welfare of the beneficiaries), and resilience creativity in different contexts (employees, students, doctors, artists & volunteers). Our research aim