RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fantastic Actors in a Night of Science' (FANS), addressing dissemination and exploitation.

assistant: **Impact**

The European Commission has called for a new edition of the Researchers’ Night to be performed in September 2010. In this context, the cultural Association Agora, in collaboration with the University of Salerno, the Municipality of Vietri Sul Mare and the Media Association Unisound have planned to join the event with a project aiming to use the cinema a powerful communication mean for the promotion of scientific progress embodied by the figure of the Researchers.Moving beyond the plot of the most famous world-wide known movies, the main features will be used to make straight reference to the scientific reality: researchers and experts from the communication sector will drive the public through the scene explaining the situation in a more meaningful and more scientific based approach. The core point of the project is to shoot with the help of the public and of the committed researchers short movies based on most famous ones in which scientific aspects are represented. During the Researchers’ Night, those catch phrases and scenes played by researchers/actors will be used to start a professional tutoring activity or a scientific and recreational demonstration open to the wide public related to the technological and scientific status of knowledge of nowadays life.The idea of this project is supported by a network of knowledge and of institutional links, like the Campania regional government that dedicated funding to promote tourism in UNESCO elicited areas such as Vietri sul Mare. This small town is a “pearl” of Amalfi Coast. In 1997 it was included in the list of Unesco and it has already been the backdrop (with its landscape and natural beauty) for famous and well-known to the general public movie scenes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Information Services and Technology Access for Biomedical Microdevices'.

assistant: **Objectives**

This proposal is based on previous activities and achievements obtained in the Europractice initiative concerning the Competence Centre for Biomedical Microdevices, termed MEDICS CC. A biomedical database structure for microdevices was established and a first contact network was built. We propose to continue these efforts providing focused information services and technology access for biomedical devices (INTECS) through MEDICS. Information services include user-friendly access to the extended biomedical database containing information on European biomedical and microsystem providers, products, services and co-operation partners. Further services comprise person to person assistance regarding the identification of co-operation partners and technology providers, the availability of components and guidance on product related solutions.Objectives:It is the objective of INTECS to apply the know-how on microdevices for biomedical applications gained in MEDICS to the benefit of European device manufacturers, scientists and clinicians.Different measures are foreseen to:1) enhance mutual awareness on existing technology and market opportunities on the supplier and user side,2) further establish a European platform for information access, network of contacts and expertise between users and suppliers,3) support partner search and access to existing European services and competence on the different aspects involved in the value chain of biomedical product development,4) provide first step support in feasibility assessment, concept evaluation and design,5) disseminate standard design microelectrode system as a key component to stimulate application oriented R&D,6) to become financially independent of EU support.Work description:The workpackage focuses on the following topics:- Awar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EU-MERCI - EU coordinated MEthods and procedures based on Real Cases for the effective implementation of policies and measures supporting energy efficiency in the Industry', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The overarching objective of EU-MERCI is to support, in a coordinated way, the growth of energy efficiency in industry processes. It will develop methods and tools for assisting EU industry in the effective implementation of energy efficiency improvements and in the monitoring of the energy savings, in application of the 2012/27/EU Directive.The methodology will be based on the analysis of thousands real energy efficiency projects implemented according with the current energy policies and measures in different MSs and dealing with tenths of different industry sectors and processes. Energy efficiency solutions will be typified according with agreed criteria concerning applications, processes and technologies: best practices, algorithms and procedures of efficiency assessment will be derived, harmonized and standardized. The goal is to answer the questions:what are the most effective actions improving the efficiency in a particular process or industry sector? How to specifically implement them? What are the most promising technologies?  What is the efficiency improvement attainable with each action? How to measure, monitor and report the savings? What are the associated costs?EU-MERCI, with recommendation and specific dissemination actions, will also assist policy makers and public authorities in the assessment of the effectiveness and transparency of the mechanisms, giving them also a picture of the technologies and efficiency improvements to incentive. Lessons learned from countries with consolidated energy efficiency schemes in place will be transferred to countries less advanced.The outputs of  EU-MERCI will be specifically validated for the agrifood industry at a pan-European level.Finally, it is expected that, as a result of the assistance to industry, the number an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovation, coordination and collaboration in service driven manufacturing supply chains' under Sixth Framework.

assistant: **Concept**

The European manufacturing industry strongly relies on external services & consumes nearly 30 % of the intermediate output of business related services. Despite this, service providers & customers are facing tremendous problems in synchronizing the business processes & facilitating collaboration. Proved concepts & tools to solve these problems are not available. The overall goal of InCoCo-S is to enhance European leadership in manufacturing systems development. The objective is to develop a set of methods to improve the overall performance of both regional European & internationally operating production systems through synchronized & well coordinated integration of the different supporting services into supply chains.InCoCo-S will address the following four unique components which have not been addressed so far in integrated service - supply chains: 1. Development of an innovative framework including the different business processes, interdependences, information flows & performance metrics for assessing the performance impact of service providers as well. 2. Make use of the framework for radical breakthroughs in the application of embedded sensor systems to optimize remote connectivity & synchronizing of decision support systems. 3. Development of a collaboration tool simulation environment to facilitate planning & decision making in an integrated & multidisciplinary environment, to force innovation & learning in multi stakeholder networks, & to be applied in professional development & training.4. InCoCo-S integrates linkages in InCoCo-S a) to SMEs, b) to Eastern European Countries including Russia, & c) to the European Manufacturing industry in order to specify industrial & societal requirements & evaluate outcomes in a comprehensive context.The developments in InCoCo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stromal stress networks underlying phenotypic plasticity and tumor fitness' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The contribution of genetic and epigenetic changes to rewiring of cancer cells into their malignant state has been much studied. But tumors are more than cancer cells and the tumor microenvironment (TME) is a key player in tumor progression. We lack an overarching view of how, despite being genomically stable, the TME is heterogeneously reprogrammed across time and space to promote evolution of aggressive disease.Recently I discovered that Heat-Shock Factor 1 (HSF1), a cytoprotective transcription factor (TF), is vital to this reprogramming, promoting malignancy in patients and mice upon activation in the stroma. Other stress TFs have also been implicated. This leads me to hypothesize that stress responses help tumors adapt and evolve into aggressive malignancies, by enabling heterogeneity and phenotypic diversity in the TME. This plasticity is achieved through cycles of massive transcriptional rewiring orchestrated by a network of stress TFs. To test this hypothesis in a global way we will proceed in three aims. First we will define patterns of stress response activation in the TME by multiplexed immunofluorescence of patient tumors. Then, we will map the associated transcriptional landscape in patients by RNA-sequencing down to single cell resolution and interrogate it in the context of a novel theory of evolutionary tradeoffs so as to discover signatures that promote tumor aggressiveness. Next, we will identify actionable nodes for intervention and test them in cell co-cultures and mouse models.The expected outcome of the proposed research is a detailed network of stress responses that can explain how the TME is rewired in tumors and how variable this rewiring is. This knowledge will provide new ways to target the TME in order to complement treatments focused on canc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A new generation of injectable implants based on Cell-Assembled extracellular Matrix (CAM)' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Injectable implants are widely used to treat numerous medical conditions, such as stress urinary incontinence, which affects 1 in 5 women. They also represent a large fraction of aesthetic procedures (e.g., wrinkle correction). The efficacy of current products is hampered by the fact that they create a chronic inflammatory response called the Foreign Body Reaction (FBR). As a result, implants have limited durability, requiring repeated procedures, and are associated with complications such as chronic pain and tissue erosion. We propose a new paradigm that avoids the FBR by providing a tissue-engineered injectable implant that is completely biological and human. This non-living product will support the creation of an actual living tissue that will be long-lasting without chronic inflammation. Our strategy is based on a unique material described in the project.The potential of this implants will be demonstrated through two work packages described in the project. Overall, this PoC will increase the technology readiness level of our product from 1-2 to 3-4 work packages. These outcomes will justify optimizing production methods, expanding in vivo analysis, and will support a commercial endeavor targeting multiple clinical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Spatial and temporal correlation of signals in t lymphocyte activation' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The aim of this interdisciplinary project is the development of a data-driven mathematical model describing the signaling properties of the immunological synapse. The immunological synapse formed between a T cell and an antigen presenting cell is a highly organized state comprising an enormous amount of T cell surface molecules such as the T cell receptor, adhesion molecules (ICAM1, LFA-1) and signaling related molecules (CD2, CD45) . We believe that the spatial organization of the molecules at the interface between T cell and antigen presenting cell plays a key role in antigen recognition. Organizing the T cell receptors ill a synapse results via serial triggering of many T cell receptors in temporal and spatial correlation of signaling events. We will combine numerical data-analysis with mathematical modeling to study this concept mathematically. Numerical data-analysis will use proper orthogonal decomposition and time series analysis. Building on the results of the data-analysis, a mathematical model of the immunological synapse will be developed. The first step in mathematical modeling will be a compartment model of the synapse which will be extended to a detailed spatial model using either partial differential equations or a lattice model (depending on the results of the data-analysis). Such a model will allow us to analyze the correlation of signaling events in the synapse which will explain how transient T cell receptor engagement yields a sustained signal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genomic diagnostics beyond the sequence' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cytogenetic diagnostic approaches provide information on the single-chromosome level but suffer from low resolution and throughput. In contrast, next generation sequencing (NGS) based diagnostics provides single base resolution and high throughput but suffer from short reads that prevent analysis of large genomic aberrations as well as being prone to PCR-amplification bias and erasure of epigenetic information. This proposal aims to bridge the gap between these domains by analyzing long individual DNA molecules without PCR-amplification via utilization of emerging optical DNA mapping technologies. We specifically address three types of challenges to current genomic based diagnostics: 1. Loss of relevant information such as DNA damage lesions, rare mutations or epigenetic markers following PCR amplification.2. Limitations in resolving long-range variations in genomic layout and correlating them with single point mutations, preventing large scale screens.3. Limitations imposed by the sample such as low sample amounts (micro biopsy, circulating tumor DNA) or inhomogeneous/highly variable samples (bacterial cultures).We will develop a robust toolbox for integrated genetic and epigenetic profiling of single DNA molecules that will include automated sample preparation of native unamplified DNA as well as the hardware and software platforms and analysis tools for readout, extraction and quantification of medically relevant genomic information. This technology will be used to develop a set of specific, proof of principle diagnostic assays based on optical barcoding of individual DNA molecules. These assays will address: -Bacterial infections and antibiotic resistance -Diagnosis/prognosis tools for hematological malignancies-Spinal Muscular Atrophy-Early diagnosis of colorectal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Forest Changes Inventory for Climate Modelling' (FORCE).

assistant: **Innovation**

Climate change is believed to be a function of concentrations of greenhouse gases (GHGs), particularly carbon dioxide. The UN Framework Convention on Climate Change has the objective to stabilise the GHGs concentrations in the atmosphere at a level that would prevent dangerous anthropogenic interference with the climate system. Forests act as carbon reservoirs by storing large amounts of carbon in trees, understory vegetation, the forest floor, and soil. Changes in forests, such as the trees' growth, can remove carbon from the atmosphere. Forest can thus act as a sink for absorbing emissions from human or natural sources. Conversely, when human activities (e.g. logging, industrial polution) or impact of natural factors (e.g. fires, insects) degrade a forest, both the reservoir and the sink potential are damaged, and the forest can become a source of carbon. From this perspective the role of boreal forests, and particularly world's largest Siberian forests, is essential, but still has to be better clarified. Accurate and updated information regarding boreal forest dynamic is crucial to quantity GHG fluxes and to predict possible scenarios of climate change. Remote sensing is the most realistic way to obtain data regarding forests dynamic within vast geographical area such as the entire boreal forest biome of Northern Eurasia. In spite of the importance of the task and the fact that numerous scientific investigations regarding the geographical extent and magnitude of disturbances dynamic of forest at the subcontinental scale and in terms, which is well compatible with the existing models of GHG fluxes estimation and climate change prediction are not developed yet and still remains to be issued of day. FORCE is aimed to fill this gap and will allow us to develop such metho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optogenetic control of collective dynamics in Epithelial Cells' (OptoEpiC) targeting Horizon Europe.

assistant: **Abstract**

Collective cell motility states, such as multicellular flocking and jamming, are active matter states that play important roles in development and disease. However, much of the dynamics of these collective states remains to be discovered. The goal of this proposal is to use optogenetics to control and understand collective cell dynamics. Optogenetics allows to control cell mechanics with unprecedented temporal and spatial precision by photoactivating the molecular machinery that regulates cell protrusion and contraction on-demand. By combining optogenetics with traction force microscopy, we will first study how single epithelial cells reshape their traction forces in response to activation of RhoA, Rac1 and CDC42. We will then investigate collective coordination of intrinsic forces and movements in response to different patterns of photoactivation of these RhoGTPases. Specifically, we will induce and steer flocks made of several cells, and we will jam/unjam well-defined regions in monolayers near the jamming transition. Active gel models will help us identify characteristic mechanical profiles of single- and multi-cellular motility. The project will yield new approaches to understand and control epithelial dynamics at the mesoscale, opening new avenues at the intersection of active matter physics and biology.


**Keywords:** Cell migration, traction force microscopy, cell guidance, optogenetics, photoactivation, active matter, flocking, jamming, tissue mechanics, multicellular systems, epithelium, monolayers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Density functional calculations for systems of unprecedented size on parallel computers' (BIGDFT) targeting Sixth Framework.

assistant: **Abstract**

Simulation is playing an ever increasing role in chemistry, physics, materials science and biology. In this research project we want to develop new simulation methods that will significantly extend the possibilities of the simulation tools available toda y. Our starting point is an existing major electronic structure program, that is based on density functional theory and plane waves and uses standard state of the art algorithms. We will try to eliminate successively all the various algorithmic bottlenecks that limit at present the application of this kind of programs to larger systems and we will implement it on massively parallel computers. The ultimate goal is to obtain a computational effort that scales only linearly with respect to system size within a systematic multi- resolution basis set. In this way we anticipate that we will be able to treat systems that are at least one order of magnitude larger than the present limit. Even though simulation methods are also mentioned in the thematic priorities 1 and 3 of the FP6 program, their existence is taken for granted and they are only mentioned as a tool in various investigations. For this reason and because of the strong interdisciplinary aspect involving physics, mathematics and computer science, the proj ect fits into the new and emerging science and technology" framework."