RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EMBRYON - Develop and commercialize a highly innovative diagnostic-imaging product, improving success rates in the Assisted Reproduction IVF sector' (EMBRYON) under Horizon 2020.

assistant: **Objectives**

Infertility is a heavy social issue,experienced by nearly one in six couples during reproductive lifetime.In Vitro Fertilization (IVF) is growing 8-10% p.a.,to 1.5 million therapy cycles and 7.5 billion dollars in 2013.Despite stressful and costly procedures,IVF success rate is low (15-20% births/cycle),leaving big opportunities for innovation and process optimization.EMBRYON introduces to IVF clinics and specialists a last-generation diagnostic-imaging system,favoring better outcomes through deeper,smarter analysis of clinical images.It merges tailored image-processing software and algorithms,patented by ACS,with a high-end commercial IVF microscope.A prototype is under validation with top clinics in Italy and Switzerland,supported by Nikon Instruments (global leader in IVF microscopy).EMBRYON improves the key success factor of any IVF procedure:the identification of 1-2  embryos with best “pregnancy potential” to be transferred in utero,amongst 5-10 generated in vitro.EMBRYON’s precision is double than current handcrafted approaches,favoring higher success rates.It is safer (100% not invasive),thus simpler to certify and adopt,fully compliant with ethical regulation,easier to use (no change to lab procedures) and cheaper than similar products.Key innovations1. Automated deep scan of embryo shape,overcoming today’s subjective and approximate observations carried by the physician2. Proprietary algorithms for the measurement of complex morphological patterns,strong predictors of potentialSales forecasts are 1200-1400 units (40-45 M€ gross revenues) by 2020 in Europe and US,favored by:- High reactivity of the IVF sector (scientists/patients) to validated solutions improving outcomes- Commercial partnership with a global IVF microscopy leaderIn Ph1 we’ll finalize and publi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Spatiotemporal characterization of extrachromosomal DNA transcription and its key regulators in cancer cells'.

assistant: **Innovation**

Extrachromosomal circular DNA (ecDNA) present in cancer cells stochastically amplifies oncogenes and drug resistance genes independent from the core genome and thereby contributes to tumor adaptability and heterogeneity. While ecDNA prevalence, diversity, and biological traits have been studied, we lack insights into their expression regulation. It is unclear how it differs from chromosomal genes and how it is linked to the non-random and dynamic nuclear localization patterns observed for many ecDNA. Moreover, we are unaware of the proteins that participate in interactions with nuclear compartments to control ecDNA transcription. Most studies using sequencing and FISH methods fall short in describing these dynamic processes. However, understanding their implications is vital for designing therapies that target ecDNA expression as a whole instead of targeting individual oncogenes. To advance our knowledge, we need tools to map ecDNA transcription at high temporal and spatial resolution and systematic methods to screen for associated proteins. The aim of this project is to identify crucial overarching mechanisms and players of ecDNA transcription through an interdisciplinary approach. The Medema group has devised protocols to induce extrachromosomal amplification of drug resistance genes in diverse cellular backgrounds and genetically tag them for imaging and perturbation. The present study will build on this work to for the first time reveal the spatiotemporal co-regulation of ecDNA transcription and localization using innovative imaging reporters for measurements in single live cells and use unbiased proteomic profiling to map factors that interact with ecDNA and regulate their expression. Besides addressing outstanding questions in the field, our study will create uniq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Size matters: scaling principles for the prediction of the ecological footprint of biofuels' in the context of a Horizon 2020 call.

assistant: **Objectives**

There is a major scientific and societal challenge in quantifying and reducing ecological footprints of products. Ecological footprint calculations suffer severely from a limited availability of data, such as the amount of energy and materials associated with the production, use and disposal of products. Furthermore, ecological footprints pertaining to biodiversity are typically biased towards a limited number of well-known species with a focus on relative species richness, leaving out ecosystem service attributes of biodiversity. As it is virtually impossible to collect all the empirical data required for all species, there is an urgent need to develop an operational framework to derive representative ecological footprints with limited data requirements. I propose to develop a novel framework based on a set of unifying scaling principles related to the production size of products and the body size of species. These scaling principles will be developed to predict key characteristics of biofuel production, such as energy return of investment, agricultural land requirements and greenhouse gas emissions, as well as global impact indicators, such as species extinction risks. The focus of the research is on (1) liquid biofuel production (bioethanol and biodiesel) from various first and second generation feedstock as an important but controversial renewable energy source (2) vascular plant diversity, as the common basis of all terrestrial ecosystems, and (3) habitat destruction and climate change, as important drivers of global change. Together with the PI, two PhD students, two Postdocs and a technical assistant will work on different components of the new predictive models, substantially enhancing the scientific understanding of how to provide reliable ecological footprints
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A modular vision recognition system for the resolution of complex 3-d objects' (1994-1998).

assistant: **Concept**

A large number of highly automated industrial production and manufacturing processes require various on-line visual assessment and/or position determination procedures. These production processes are many and varied ranging from the visual quality assurance of foodstuffs to location and robotic selection of machined parts whilst moving along a production line. Computerised vision recognition systems offer a non-contact, non-destructive measurement technique that can be readily incorporated into closed loop control methods within automated manufacturing processes. The specific industrial process for which this development project is initially targeted is the automated re-stocking of steel cages for the transportation and retail display of plastic bottled milk commonly encountered in supermarket grocery stores - specifically with respect to the monitoring of damage of the steel cage. This presents a number of generic problems to more advanced recognition systems as well as acting as a detailed demonstrator of the developed system application. The overall intent is thus the development of a highly modular computerised vision recognition system that will be of low cost. The developed modular system will be capable of, via the appropriate tailoring specific to the intended task, - the inspection of many different products; 3 dimensional complex non-solid or solid, - will require little or no expert reprogramming of the system once installed, - be compatible with the typical industrial automatised software and hardware. The actual research and technical development accomplished by this project will be fundamental in nature with the design and construction of a prototype system suitable for the specific dairy and one other application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bioceramics: Multiscale Engineering of Advanced Ceramics at the Biology Interface' (BIOCERENG).

assistant: **Concept**

In the last decades, Materials Sciences and Life Sciences, two highly dynamically evolving and interdisciplinary research areas, have been influencing natural and engineering sciences significantly, creating new challenges and opportunities. A prime example for an increasing synergetic overlap of Materials and Life Sciences is provided by biomedical and bioengineering applications, which are of great academic, but also of steadily increasing societal and commercial interest. Bridging the traditional borders of disciplinary thinking in these areas has become one of today’s most challenging tasks for scientists. One group of key materials that are of great importance to biomedical engineering and bioengineering are advanced oxide and non-oxide ceramics with specific functionalities towards biological environments, so-called Bioceramics. The interplay at the interface of ceramics-protein-cells/bacteria is very complex and requires multiscale and interdisciplinary approaches. This expertise, that is under continuous development in my Bioceramics group, encompasses materials processing, shaping, surface functionalisation and cells/bacteria evaluation at the same time. The comprehensive research environment and expertise provides a unique opportunity to engineer materials/surfaces with immediate subsequent biological evaluation in order to achieve an extremely short development time. A centre of focus is the contribution of electrostatic and hydrophilic/hydrophobic interactions to the overall biocompatibility and -activity. The proposed research project includes four closely interrelated subprojects, addressing the following topics: “Interaction of surface functionalised ceramic particles with proteins”, “Cytotoxicity of functionalised oxide particles”, “Fabrication and testi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Procurement Capability - Embedding and Driving Innovation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

PROcurement Capability - Embedding and Driving INnovation (PROCEDIN)Legal reforms, European, national and regional policies, growing expertise, guidance, tools and case studies, and networks of early adopters are all key foundations for the adoption of (public) procurement of innovation (POI) practices, bringing together business and public sectors. If it is to drive deep, systemic change, the rate, scale and scope of POI adoption must increase. This project will accelerate POI in a specific domain covering two critical areas of innovation  – circular economy and green mobility – in the context of European cities’ innovation for sustainability and resilience agendas.The consortium will leverage existing resources and its members’ extensive, pan-European professional networks, and initiate new provisions, to enhance and mobilise POI motivation, knowledge and skills. By mapping the complex landscape of growing expertise, experience and learning infrastructure, and relating resources to the varied needs of different stakeholder archetypes (defined by organization type, extent of POI experience etc), key gaps in provision will be identified and addressed. Particular attention is paid to promoting enduring access to, and increased uptake of, POI guidance and learning resources for buyers and vendors, and to building leadership capacity for driving and embedding innovation through strategic procurement.


**Keywords:** Public procurement of innovation, Pre-commercial procurement, Entrepreneurship
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improved spatial Frameworks for river environment management' under Sixth Framework.

assistant: **Concept**

European Water Framework Directives such as reaching a 'good ecological status' require that achievable conditions be assessed, and restoration targets are set, over large areas. In this context, spatial frameworks (delineation of ecological pattern) are used to predict ecological potential over large scales and to implement harmonious ecological objectives. We propose to undertake management-oriented research to develop new spatial frameworks for river management.Methods, developed by the researcher in New Zealand, provide high spatial resolution ecological classifications of rivers and use advances in Geographic Information System and classification methods. In contrast with existing regionalisation approaches (subdividing landscapes into large regions), they classify individual segments of digital representations of river networks using functionally important ecological attributes (of the segment or inherited from the river's catchment through the network structure).Our first and second objectives are to define new classifications and compare them with existing regionalisations. Tests will be based on taxonomic and functional descriptions (e.g., biological traits) of river ecosystems. Objective three is to use the classifications to extrapolate existing general ecological models to entire river systems (e.g., models of ecological responses to flow modifications). The work will be based on available databases, models and tools. Tests using functional descriptors are uncommon and can demonstrate the generality of our approach. Spatial extrapolation of ecological models will increase their value as management and research tools. The researcher will work in an environment with a strong background in ecological research, modelling and spatial framework development. The pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Super-span soil-steel bridge (animal crossing) – backfill and long-term monitoring'.

assistant: **Innovation**

Metal soil-steel bridges are getting more and more popular in Europe in recent years.Four identical large-span flexible structures SuperCor will be constructed on A4 motorway in Poland.The structures will be low-profile arch metal culverts with a span of 19.5m and a rise of 6.0m.The culverts will be served as animal crossings.The primary objectives of the proposal are connected with realization of fullscale field tests of one of mentioned structures during backfilling operation and long-term monitoring of behaviour after the end of construction. The main research objectives are the following:1)Investigation of strains and deformations in metal plates of culvert during backfilling operations,2)Long-term monitoring of behaviour of a large-span metal structure after the end of construction,3)The analysis of the results, and the calibration computer codes used to the Finite Element Method(FEM) to model the behaviour of large-span culverts. The important objective of the proposal is detailed analyses of test results.Numerical culverts models will be created using the FEM and these FEM systems will be adjusted for geotechnical purposes.The experimental data obtained under field and fullscale tests are urgently needed to verify geotechnical software and development design methods.The other objective is to run a new course by applicant entitled:""Flexible buried structures""at the host institution.The course will concern testing,designing and constructing buried structures and it will be run together with one of the experts from Norway. One of the aims of Human Resources and Mobility Activity is to increase mobility of researchers in Europe as an instrument of researchers’ exchange between universities and industry.The proposal certainly meets this aim enabling the applicant to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Intelligent Route Guidance of Heavy Vehicles'.

assistant: **Concept**

The volume of freight transport on European roads has increased over the years and is expected to grow significantly in the next decade. Increasing gross weights and changing load configurations of heavy goods vehicles (HGVs) has led to an accelerated damage to bridges and pavements as well as major traffic management problems. The consequences are rising costs for maintaining roads in a good and safe condition and a network operating at sub-optimum efficiency with increasing capacity, safety and environmental impacts. Truck operators, face the combined challenges of reducing ever increasing fuel costs, maximising efficiency and profitability whilst maintaining safety. Truck drivers have the additional tasks of ensuring compliance with driver?s working hours. regulations and finding appropriate, safe and secure rest areas. One major support for all three parties would come from the improvement in the generation and usage of digital maps for trucks in Europe that will effectively link Europe?s road infrastructure via electronic mapping systems to the truck operators and drivers. The HeavyRoute project aims to develop an advanced route guidance system for HGVs as a tool for deriving the safest and the most cost effective routes for road freight transports throughout Europe. The system will for the first time take into full account road user needs, vehicle operating and environmental costs as well as maintenance costs for the road owner/manager due to deterioration of roads and bridges.The system will be built on available and implemented technologies such as fleet management and logistics systems, guidance/ rerouting systems, traffic monitoring and management systems, dynamic map updating and various ITS solutions.Working with all the major stakeholders,with FEHRL and ERT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of symplastic communication during root development', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The symplastic route composed of plasmodesmata (PD) channels and the transporting phloem tissue (rich in PD) is the major pathway for carbon allocation in plants. How the symplastic transport route is formed during plant ontogeny and what is its significance in conducting and distributing morhogenetic signals to the growing organs is poorly understood at the moment and is addressed here. My laboratory has recently made a breakthrough that facilitates the analysis of symplastic communication. In a genetic screen we identified gain-of-function mutations in a locus that codes for a CALLOSE SYNTHASE isoform CALS3. The cals3-d mutations result in restricted symplastic trafficking through the PD. Using the cals3-d mutations in a vector system that allows cell type specific and inducible control of expression of the transgene, icals3m, we have been able to construct a molecular tool, with which we can regulate the passage of the various signaling molecules between the neighboring cells. This tool has already opened several new lines of research on symplastic communication concerning understanding of the regulation of PD channels, phloem development and symplastically moving signals. By a combination of experimental approaches at molecular, genetic, imaging and theoretically levels we will investigate here:(1) How is symplastic trafficking regulated?(2) What are the (symplastic) signals specifying phloem development?(3) How do the signals emanating from the phloem control root development?(4) Can we predict new regulatory factors controlling symplastic trafficking in space and time, based on the experimental data (on the distribution of symplastic channels, symplastically controlled genes and symplastically mobile molecules)?