RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genome Mining-Based Discovery and Engineering of Trojan Horse Peptide Antibiotics Against Gram-Negative Pathogens', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Antimicrobial resistance (AMR) is a growing global threat, with the World Health Organization highlighting Gram-negative pathogens as a critical priority. New antibiotics with innovative modes of action are urgently needed. This project aims to discover and characterize a previously unexplored biosynthetic gene cluster predicted to encode a hybrid natural product that links two major peptide classes: ribosomally synthesized and post-translationally modified peptides (RiPPs) and nonribosomal peptides (NRPs). Such hybrid pathways are extremely rare and represent a promising but uncharted area for antibiotic discovery.The first objective is to identify and structurally characterize the natural product encoded by this pathway. This will be achieved using genome mining, bioinformatics, and heterologous expression of candidate genes, followed by isolation and advanced qualitative organic analysis methods such as NMR and MS. The second objective is to investigate the structural basis of the encoded RiPP, which is predicted to form a β-helix through an alternating L/D residue pattern. Biophysical methods will test whether this fold contributes to antibacterial activity, for example through ion channel formation. The third objective is to characterize the unique enzyme responsible for attaching the NRP to the RiPP scaffold, which represents a new enzymatic function at the interface of two biosynthetic classes. This enzyme will be studied using biochemical assays and engineered through directed evolution to assess its potential for generating “mix-and-match” antibiotics.By combining natural product discovery, structural biology, and enzyme engineering, this interdisciplinary project will provide new insights into peptide biosynthesis and resistance-evading antibiotic mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DISTANT OFFSHORE WINDFARMS WITH NO VISUAL IMPACT IN DEEPWATER' (DOWNVIND), addressing dissemination and exploitation.

assistant: **Impact**

BEATRICE OFFSHORE DEEPWATER WIND FARM INTEGRATED PROJECT Talisman Energy is co-ordinator of the BEATRICEWINDENERGY multidisciplinary consortium of European stakeholders whose objective is to lead in the global market of installing and operating deepwater offshore windfarms. The consortium considers it feasible, albeit with substantial risk, to develop a new generation" of wind turbine installation suited to offshore operations by making step change improvements in existing components design and utilising new approaches to manufacture, installation and "life of file" maintenance. However, to realise this aim a reduction on present day capital costs in the order of 20% will need to be achieved. The objective of the Beatrice Offshoree Deepwater Wind Farm Integrated Project is to meet or exceed this cost reduction target by RTD and innovation in four main areas."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing User-centred Approaches to Technological Innovation in Literary Translation (DUAL-T)' (DUAL-T) targeting Horizon Europe.

assistant: **Abstract**

Recent years have seen a growing research interest on the application of translation technology to literary translation workflows, mostly in the form of Machine Translation (MT) or post-editing of MT output. In these studies, literary translators' voices are virtually absent. This project will address the discrepancy between research in Computer Science/AI and Translation Studies, as well as the absence of literary translators from the conversation surrounding technological innovation in their profession. It will do so by proactively integrating literary translators' input in the co-creation of a new technology-inclusive workflow. Professional literary translators will be asked to perform literary translation tasks using (1) MT + post-editing, (2) a Computer-Aided Translation (CAT) tool environment, (3) a CAT tool environment with integrated MT. User testing will be performed using eye tracking, keystroke logging and screen capturing. In-depth interviews and focus groups will be conducted before and after the translation task to register changes in participants' attitudes towards technology before and after using it, as well as advantages and pain points of the tool employed. Being the first study of this kind in literary translation, results will help to (1) devise a technology-inclusive literary translation workflow employing a user-led approach, (2) assess whether and to what extent translation technology can enhance literary translators (particularly, the potential of CAT tools to work in combination with MT and/or as an alternative to MT-centric approaches will be assessed), and (3) mediate a dialogue between literary translators and translation technology developers by feeding back data on literary translators' use of and attitudes towards translation technology t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dietary habit profile in european communites with different risk of myocardial infarction: the impact of migration as a model of gene/environment interaction' (IMMIDIET), addressing dissemination and exploitation.

assistant: **Impact**

Risk factors influenced by both nutrition and genetic polymorphisms will be studied in 3 European communities by general practitioner's networks. Firstly, 270 Be/Be couples in Belgium will be compared with 270 age- and sex-matched It/It couples in Italy and 270 UK/UK couples in U.K. Migration of Italians to Belgium will be used as a model of interaction between nutrition and genetics, to explain differences in the prevalence of cardiovascular risk across Europe. For this purpose, 270 mixed couples, formed in Belgium by a It/Be marriage, with the same range of age of the It/It, Be/Be and UK/UK couples, will be recruited. Members of the mixed couples will be compared between them and with It and Be couples. A new Multilanguage food frequency questionnaire (FFQ) will be developed to evaluate dietary factors and analysed with an adapted program, using integrated tables of food composition.The IMMIDIET project has reached all its deliverables and milestones. It has produced an enormous amount of data that have contradicted several common believes and should have a strong impact on national and European public health policies. First of all, the so called North-South" gradient of risk and probably mortality for cardiovascular disease is disappearing. England that was considered the country at highest risk of cardiovascular disease, is improving successfully its situation, at least in some of its regions. Although not representative of the whole country situation, these data demonstrate that by modifying life style, such as dietary habits, smoking habits, physical activity and so on, it is possible to stop and even revert the increase in the risk of cardiovascular disease. Particularly worrying is the observation on blood pressure and sodium clearance. There is a clear-cut tren
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Micro-endoscopes for in-depth high-resolution optogenetics' under Horizon 2020.

assistant: **Concept**

Understanding how the brain works is one of the grand scientific challenges of our times and constitutes a priority research line for the European Union. The study of the brain mechanisms that underlie fear learning and response is particularly relevant as it could provide the key to control anxiety disorders, with an associated high social and economic benefit for the European community.Recent studies indicate that specific areas of the amygdala, a structure located deep within the brain’s medial temporal lobe, are crucial for the generation of fear responses in mice. To gain more insight, it is now necessary to understand how individual neurons in these areas act and collaborate together to generate the appropriate response. Crucially, this requires the capability to observe and manipulate fear circuits in deep brain structures with single neuron resolution. However, reaching at the same time sufficient depth and high resolution represents a great experimental challenge. At present no technique exists that can enable such a study.The objective of the project is to overcome the current experimental limitations and develop a new optical method for the precise imaging and manipulation of neurons even deep in the brain of living animals. To this end we will extend advanced high-resolution optogenetic stimulation and imaging techniques to an optical micro-endoscope capable of reaching the desired depth in the brain of mice. Proof of principle experiments in vivo in the amygdala of mice will be performed.This highly multidisciplinary project, at the frontiers between optics and neuroscience, will require the great expertise of the host group in optogenetics methods, the strong background of the fellow in high-resolution optical techniques and the collaboration with an exter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Project on tendency evaluations using new techniques to improve atmospheric long term simulations', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives : To identify and minimise the tendency and forcing errors in four different atmospheric general circulation models (GCMs). The improved models will be developed and tested with special attention to simulation of regional climate over Europe and to seasonal prediction of climate. Brief Description of the Research Project : Two state-of-the-art atmospheric climate models and two simpler GCMs will be used. Different techniques will be applied to calculate the forcing errors, but the basic method, to be tested in all four GCMs, consists of a simple four dimensional data assimilation technique called nudging. In nudging a given model is constantly relaxed towards data which varies in time. In the present application these data will be the ECMWF Re-Analyses (ERA) and the magnitude of the relaxation will with different constraints be used as a measure of the models forcing errors. The work will have an iterative character where improvement of the GCMs will be guided by the temporal and spatial distribution of the forcing errors and by the characteristics of the systematic errors seen in climate runs. The improvement of the GCMs will follow two lines, improvement of physical parameterization, and developments of empirical parameterization of the forcing errors. The performance of physical parameterization will be validated with special attention to simulation of regional climate over Europe and elsewhere since such errors severely degrades the performance of regional climate models which receive boundary conditions from the GCMs. Along the second line the focus will be on testing the seasonal prediction capabilities of GCMs which include the empirical parameterization or correction of their forcing errors. Such dynamical within-forecast corrections will be compared
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Characterization of fatigue damage in engineering materials by in-situ positron annihilation' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content Recent progress in the technique of positron annihilation measurements enables a non-destructive, highly sensitive detection of microstructure changes during fatigue. The proposed project shall evaluate the potential of this new method as a tool of non-destructive fatigue damage characterization, the possibilities of residual fatigue lifetime assessment and its potential in non-destructive testing. To this end a series of in-situ positron lifetime measurement campaigns during the fatigue of some well-known engineering materials (AISI 316 L stainless steel, aluminium alloy Al 2024) in different microstructural states is planned in order to obtain the positron lifetime as a function of stress amplitude and number of fatigue cycles. The changes in positron lifetime will be related to microstructural changes identified by electron microscopy (TEM, SEM), X-ray diffraction and metallography. A relation will be set up between the microstructural changes, significant changes in positron lifetime and the residual lifetime estimated from the Wvhler curve. Training content objective benefit and expected impact) The research training grant would offer the possibility to use the ideal combination of research facilities at the IAM in order to develop a method of nuclear solid state physics into a potential tool for industrial application. The presence of experienced researchers and the integration of the IAM in European applied research ensure the success of the proposed project. The scientific training in the techniques of microstructure analysis (electron microscopy, X-ray diffraction, metallography) and mechanical testing available at the IAM together with the experience of working in an international research organization would be a unique possibil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'No Biofouling Surfaces' under Horizon 2020.

assistant: **Concept**

Biofilms consist of bacteria, proteins and cells which attached to a solid surface. Prevention of biofilms is of extremerelevance in industry and science as they are ubiquitous and able to provoke corrosion or failure in pipelines, heat exchangers, biomedical devices, artificial implants or food processing facilities. Biofilms are often battled with antibiotics,but bacterial resistance is a major problem. Therefore, novel approaches are required to avoid biofouling. We will explore the application of (1) superamphiphobic coatings, (2) slippery liquid infused porous surfaces and (3) functional pillar arrays surfaces to battle biofouling. These surfaces have in common that they strongly repel water, blood and organic liquids,and even soap-water mixtures due to a synergy between rough topography and a special chemistry. We will monitor and characterize the adhesion of bacteria, proteins and cells to these surfaces depended on shape, size andchemical of composition of the surface and the liquids. Several classical and highly advanced cutting edge methods will be used to investigate the wetting and fouling properties of these surfaces, especially laser scanning confocal microscopy. In the final steps of the research, we will evaluate the robustness of the surfaces and the biocompatibility in orderto establish potential real applications in collaboration with industrial partners. We exert a high impact of this fellowship to the scientific community and the rest of society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ENROUTE: WORK YOUR RIDE' to be submitted under Horizon 2020.

assistant: **Abstract**

Enroute Ltd. is a privately held company founded in Israel with the vision of providing passengers with the best experience intheir newly created enroute time. After successfully piloting the prototype version of Enroute technology, the team will beable to confirm the capability of its breakthrough product to open new markets in Europe with the potential for rapid growth.By pursuing the present feasibility study, Enroute’s management team aims to improve its understanding of internationalmarket conditions and the associated risks that need to be considered as the company develops a deeper business plan forrolling-out, and scaling up Enroute as a marketable innovative solution. SME Instrument Phase-1 and Phase-2 will beextremely beneficial in helping the company to accelerate development and market penetration of the Enroute solution intarget segments, boosting the company’s growth to 45 employees and €84,6M revenues by 2025.


**Keywords:** Travel, time, new business model, mobility software
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Finite and Algebraic Geometry for Error correction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The primary objective of the FACE project is to study and develop the connections between Coding Theory and non-linear geometric objects in Galois spaces, by using both theoretical and computational instruments. The FACE project will  focus on particular types of non-linear geometric objects: arcs, (n,r)-arcs, caps, saturating sets, and algebraic varieties. These objects correspond to specific types of linear error-correcting codes. These codes are deeply involved in the process of transmission of information, since they preserve the information against errors occurring during the transmission process on a communication channel; without this protection the information received could be unusable. The main aim of the FACE project is to construct and to classify new examples and new infinite families of the geometrical counterparts of linear  error-correcting codes with good parameters, i.e. correcting a large number of errors with respect to their length.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modification of receptor tyrosine kinase signalling during tumour cell migration' (MODSIGN).

assistant: **Concept**

Cancer is a major socio-economic problem in EU, with approximately 2.5 million cases diagnosed and 1.2 million deaths every year, and an annual estimated cost of 15 billion € for cancer therapy. Understanding the molecular mechanisms underlying cancer progression have revolutionized the field of targeted therapies, generating a growing number of inhibitors approved for use in the clinic. In particular, drugs targeting receptor tyrosine kinases (RTKs) have been successful. Although several of these therapies showed initial benefits, a recurring problem in cancer management is development of secondary mutations of the targeted proteins, causing drug resistance. To counteract this, there is an urgent need to identify the next generation of drug targets required to create the second line therapies that are critically needed. The specific aim of this proposal is to elucidate the molecular networks that modify RTK signalling output during tumour progression to metastatic disease, with the aim of identifying network nodes that can subsequently be targeted for drug development.The goal of this proposal is to investigate the molecular mechanisms whereby RTK signalling output is modified, and how they are altered during cancer progression to metastatic disease.  In vivo, tumour cells are simultaneously exposed to signals initiated by a variety of oncogenes, cytokine receptors and adhesion molecules, and it is the integrated signals that determine the cellular phenotype. Realizing that cancer is a disease of networks, this proposal investigates signal integration at the level of regulating RTK internalization and trafficking. Specifically, the proposed research will significantly expand the understanding of the intersection between two interlinked networks that regulate RTK signal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Innovative Transactive Renewable Energy Communities' (INNO-TREC), addressing dissemination and exploitation.

assistant: **Impact**

INNO-TREC brings together a group of preeminent energy industry and research partners focused on revolutionising the RECs sector. It is fully aligned with the EU’s vision for the energy transition as it proposes to develop the next generation of tools, methodologies and platforms that really work for RECs. These advancements will be fully tested and demonstrated in 6 DEMOs in 6 countries (Portugal, Greece, Belgium, Ireland, UK and Italy). INNO-TREC will address the barriers, motivations and drivers from energy users' perspective, intertwining the new technological developments with SSH expertise, thus producing high-level TRL 6-7 innovative results by the end of this project.


**Keywords:** Renewable Energy Communities, Photovoltaic Systems, Transactive Energy, Digital Tools, Markets