RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Evolutionary genetics of transcription factor binding in closely related mammals'.

assistant: **Concept**

The genetic differences found in gene regulatory regions are the largest contributing factor to the diversity of phenotypes within and between mammalian species. However, the micro-evolutionary mechanisms active in closely-related species remain poorly explored, particularly in mammals.In Aim 1, we will exploit five recently sequenced mouse species to determine how often genetic sequence differences alter both the genome-wide binding and regulatory output of a core set of tissue-specific transcription factors (TFs) known to act combinatorially in liver. This project aim will establish the micro-evolutionary processes that drive interspecies changes in transcriptional regulation.In Aim 2, we will create first-generation intercrosses of a subset of these mouse species to dissect the cis and trans contributions to TF binding differences between species, and to explore the functional implications for nearby chromatin and gene expression. This aim will also establish whether any tissue-specific TF binding sites show parent-of-chromosomal origin effects.In Aim 3, we will use classically generated TF knockout mice to identify a set of functionally enriched TF binding sites, which will be further categorized by their conservation across the five mouse species. Then, using the revolutionary ability to rapidly and precisely delete individual binding sites (as well as combinations of binding sites) in the mouse genome by zinc finger nucleases, we will test whether conservation of these protein-DNA contacts can predict functional activity at target genes.This integrated approach combines the comparison of TF binding in closely-related mammals with powerful new experimental tools to afford a comprehensive understanding of the genetics and mechanisms underlying the micro-evolution of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'SOLGREEN MESSE BASEL - PHOTOVOLTAIC POWER PLANT IN COMBINATION WITH GREEN ROOFS ""'.

assistant: **Concept**

Flat roofs can easily be equipped with a vegetation as roof surface. Many cities require that for better water management in order to lower drain water peaks. It is important to show and demonstrate, that such roofs can also be used for photovoltaics. The combination with green roofs creates also benefits to the photovoltaic system itself. using the substrate for the plants as weight foundation for the solar panels helps to save materials and the PV modules under all weather conditions as well as the specific needs because of the green roof. the proposed Solgreen-System allows an easy use of conventional grass cutting machines.Planned photovoltaic peak power : 300 kWp Estimated annual energy production : 270000 kWhThe planned solar generator has a nominal power capacity of 300 kWp and will be the biggest building integrated power plant in Switzerland for the time being. it is located on the flat roof of the new exhibition hall of Messe Basel. Every year 20-30 exhibitions are organised which are visited by about 1 Million people.The used system is called SOLGREEN", which means the combination of photovoltaics with the green roof cover. A special mounting structure is going to be used which involves metal tubes combined with mats to use the weight of the organic layer as a load and anchors for the PV panels. It is an easy and low cost way to mount photovoltaic modules on flat roofs and it takes care of the aesthetic aspects with a green roof in the middle of the city of Basel. Minimised amount of materials are spent reducing the energy pay back time the exact system structure is not yet defined. It is subject to call for tender."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Spatiotemporal regulation of centriolar satellite homeostasis' (SatelliteHomeostasis).

assistant: **Concept**

Membrane-less compartmentalization has emerged as a powerful, yet mysterious, process for the spatiotemporal control of fundamental cellular processes. How the identity of a membrane-less organelle is established, maintained, and dynamically altered remains unclear. In this project, I will investigate the fascinating biology of the centriolar satellites (hereafter CS), a vertebrate-specific membrane-less organelle. CS was first discovered as granules that cluster and move around centrosomes – major microtubule-organizing centers of animal cells. Recently, my lab and others have placed CS in a new pathway for targeting proteins to centrosomes and cilia, and identified an important role for CS in cell division, cellular signalling and neurogenesis. While CS functions shone light in these organelles, little is known about their own biochemistry and how that affects their function.Recent studies, including my own, revealed unique and intriguing CS properties that likely underlie the rules underpinning their regulation and function. The properties of CS granules are regulated in space, time and tissue, as we observe differential size and composition within the cell and in different cell types. Building on these discoveries, I hypothesise that CS perform its different functions by acting as adaptive organelles that remodel its granule features in response to intrinsic and extrinsic cues. With this project I propose to investigate the molecular basis of (1) CS scaffold assembly and disassembly, (2) CS granule size, composition, architecture and dynamics; and (3) CS heterogeneity within a cell and in different cell types. This project will combine in vitro reconstitution, imaging-based assays, a new SatelliteGFP mouse and our expertise in proximity proteomics and biochemical pu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Fluctuations in classical and quantum systems: superfluid helium, 2D electrons, chemistry, physiology, the early universe and other non-equilibrium systems'.

assistant: **Objectives**

Nonequilibrium fluctuations pervade almost all areas of science, and represent a topic of extreme dynamism. They lie at the root of many fundamental concepts of statistical physics and are responsible for e.g. quantum tunnelling giving rise to vortex creation in superfluid helium, cosmic strings in the early universe, chemical reactions, and important phenomena in nonlinear dynamical systems, physiology, and two-dimensional electron assemblies - as well as impacting on social and economic problems. The purpose of the proposed workshop is to bring together a group of scientists that do not normally meet or communicate, but all of whom work on nonequilibrium fluctuations.They will be drawn from UK, Italy, Spain, Germany, USA, Ukraine and Russia. Major points of emphasis will be on macroscopic quantum tunnelling as representing one of the most (if not the most) fundamental type of fluctuation, and on helium superfluidity which provides a unique tool for investigating such fluctuations. Leading specialists working on quantized vortex creation, and fluctuational phenomena in 2D-electron systems on the superfluid surface will meet - in most cases for the first time - with fluctuational dynamicists. The meeting will thus provide a unique opportunity for direct discussion between two distinct scientific communities. It will therefore facilitate a search for possible breakthroughs in the understanding of large fluctuations in systems far from thermal equilibrium.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00297-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Multimodal Interaction for Remote Physical Artefacts'.

assistant: **Objectives**

Digitally replicating the tactile, spatial, and multisensory qualities critical for interacting with physical objects remains an unsolved complex problem. This is challenge is felt acutely in cases such as remote collaboration, which is central to modern work practices, offering flexibility and sustainability. Significant challenges arise when physical objects are integral to collaboration. MIRA answers the question:How can we create a multimodal proxy for remote physical objects, effectively replicating and going beyond the experience of in-person interaction with the actual object?MIRA proposes a new Theory of Interaction with Remote Physical Objects by combining research in Human-Computer Interaction, psychological theories, and innovative applications integrating materials science and Multimodal Interaction. Central to this is the creation of a new class of interactive tools, termed multimodal proxies. The effectiveness of these proxies will be tested by designing effective and engaging remote collaboration systems.  MIRA has three objectives:  1. Develop Foundational Principles: Establish a novel set of principles for designing systems supporting remote interaction with physical objects. This has never been done before and will draw on psychological theories and empirical data from large-scale interview and observation studies.  2. Create Multimodal Proxies: Develop a new class of interactive tools that simulate the physical properties of remote objects, integrating sensory feedback—visual, auditory, and haptic—for synchronized interaction, addressing technological asymmetries.  3. Extend Interaction Paradigms: Explore unique affordances of multimodal proxies to unlock interaction possibilities beyond those in traditional co-located settings, for richer, more trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CULTURAL CHANGE AND HUSBANDRY DEVELOPMENT IN EUROPE: ZOOARCHAEOLOGICAL EVIDENCE FROM THE IRON AGE – ROMAN TRANSITION IN IBERIA AND BRITAIN' in the context of a Seventh Framework call.

assistant: **Objectives**

Livestock has been one of the main productive activities in Europe since the introduction of domestic mammals around 8000BP. The study of animal remains from archaeological sites provides reliable information on eating and husbandry changes resulting from population growth and social complexification processes. The Iron Age to Roman transition represents a very interesting case study, as it is associated with a change from ‘close’ or ‘regional’ economies to a centralized ‘world socio-economic system’. Although the existing evidence for diet and livestock improvement during the Iron Age and Roman transition is intriguing, little comparative research has been possible in Europe due to the lack of detailed published data. This project will provide original work and a survey of the species and products exploited in different European areas, using Iberia as the key case study and Britain as a comparative example.  The results will provide a comprehensive picture of the husbandry strategies adopted in Iberia and Britain in the context of a demographic change occurring at a pan-European scale.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated modular solution for handling of flexible materials in an industrial environment' (HANDFLEX) targeting Fourth Framework.

assistant: **Abstract**

The overall objective of the HANDFLEX project is to acquire and improve the state-of-the-art knowledge on the behaviour of delicate" (i.e. materials that cannot be pulled, bent or twisted when being handled through the various manufacturing phases) materials when these are handled in manufacturing processes. To do this, 3 case studies have been put up in order to provide the widest research field and evaluate different cases with very different materials and different industrial environments, from SMEs discontinuous processes to large company continuous processes, to robotised manufacturing chains. The specific objectives for the 3 systems were:* System 1: to set up an advanced and highly specialised robot with complex designed grippers having the innovative ability to handle flexible materials at any production stage of the process. A common task for any car manufacturer was chosen for System 1: mounting cable forms into a car doorframe. The problem of assembling cable forms and other deformable, linear objects (like hoses, ropes, (leaf) springs) is investigated from a more general point of view. This method ensures that the results of the project can be used in a wide field of industrial applications.* System 2: to get the prototype robotized installation for automatic production of the heating elements or resistance that EIKA uses for their heaters and automatic laying of such heating elements along a distribution groove in a ceramic base plate. At the moment handling and laying operations are manually done and require expert operators in order to get the production rate and quality that EIKA requires. The heating element that is manipulated is a very flexible material and the manipulation operation results on a difficult and extremely repetitive monotonous operation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nanocapsules for targeted delivery of radioactivity' (RADDEL) targeting Seventh Framework.

assistant: **Abstract**

The consortium RADDEL (RADioactivity DELivery) has a research-based approach for the training of the new generation of scientists in the development of novel functional nanomaterials . A well structured training program will be provided with a balanced combination of local and network-wide training through secondments, joint network meetings, workshops, schools, industrial training and the final network conference. The research program focuses on the design, synthesis, characterisation, pharmacological studies and dosimetry calculations of nanocapsules that seal in their interior radioactive materials for biomedical applications in the areas of cancer diagnosis and therapy. After sealing the chosen radionuclides, the external walls of the nanocapsules will be decorated with biomolecules to render them biocompatible and for targeting purposes. In a recent study we have recently observed that these nanocapsules allow the delivery of unprecedented radiodosage and remain stable for extended periods thus guaranteeing essentially zero leakage of the radionuclides. Surface functionalisation of these nanocapsules offers versatility towards modulation of tissue biodistribution of the radioemitting crystals in a manner determined by the nanocapsule that delivers them. The delivery of radioactivity takes place through the walls of nanocapsules (carbon) and release of the encapsulated radionuclides is therefore not needed and certainly not desired. The present research objectives go beyond the-state-of-the art in the field and innovative products and solutions are expected.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Solving major problems in MicroSensorial Wireless Networks'.

assistant: **Concept**

Sensorial Wireless Networks (SWN) are wireless networks consisting of a collection of spatially separated tiny nodes (smart dust sensors, motes) that autonomously form and maintain a network through the wireless medium. As models for mobile wireless networking their appeal comes from the fact that they can operate autonomously without the need for an existing infrastructure. SWN have direct applications in mobility, presence detection, source detection, source localization, source tracking, security, environmental control, habitat monitoring, medical control, highway traffic management, building and industrial monitoring.Focused on a technological and horizontal research to obtain standard paradigms to unsolved problems related to SWN, the main project objective is to research generic and reusable Software-Hardware solutions that are common to existent and potential future applications, and that could serve as readily available and standard SWN design and deployment solutions. The research on the generalization of the problem of SWN architectural design and deployment will be biased to obtaining solutions that although generic allow for further fine-tuning when a given application is considered.Specifically, we are going to research the optimal deployment systems for the sensors in different generic scenarios and optimal routing and communications protocols under premises of autonomous setting on, low energy use and low memory and bandwidth capacities. Moreover, we will focus on researching and developing of reusable Middleware components to ease future development tasks with this kind of systems under real-time restrictions. For these tasks different application scenarios will be studied and one or more generic scenarios will be taking into account. Therefore, a contro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a smart shape-memory sensor for biological pressure monitoring applications' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Hypertension is the leading global contributor to premature death, accounting for over 9M deaths worldwide each year. Elevated blood pressure (BP) is a chronic lifetime risk factor. If left undiagnosed or poorly controlled, high BP can lead to serious cardiovascular and cerebrovascular events. Whereas long-term BP monitoring is required in many high-risk patients, there is no clinically accepted method of continuous BP monitoring that can be used outside of hospital settings. Thus, there is an unmet clinical need and a huge market opportunity for a medical-grade, user-friendly, and minimally invasive solution for long-term, continuous BP monitoring. The SMARTSHAPE consortium has developed and IP-protected a technologically disruptive sensor for continuous pressure measurement. However, several challenges related to biocompatibility, longevity, and delivery to the target tissue need to be overcome to deliver the sensor to the market. This project will address these challenges by formulation of an innovative biomaterial: a novel temperature-dependent shape memory polymer (SMP). The use of SMPs will enable the development of a microsensor that can be curled up, introduced into the body through a minimally invasive procedure, and ‘opened up’ when placed at body temperature to take a pre-defined shape. After integration of the biomaterial in the sensor, validation data will be generated for proof-of-performance, longevity, biocompatibility, safety, and sensor delivery through bench testing and in vivo preclinical studies. Quality and manufacturing aspects will be addressed and a regulatory strategy and lifecycle assessment delivered. BP monitoring will represent the first application, but the potential of the sensor goes far beyond that. Use cases for other healthcare applic