RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Oncolipidomics: Why is lipidomic dysregulation pattern in blood similar for various cancers?' to be submitted under Horizon Europe.

assistant: **Abstract**

Lipids are involved in numerous pathways of human metabolism that are related to pathological states. Alterations of lipid concentrations in the blood of cancer patients have been reported but the biological origin is still unknown. Deciphering the mechanisms of the lipid dysregulation mechanism could dramatically change oncology because it can open new avenues for cancer detection with subsequent effective treatment and drug development targeting dysregulated pathways. Early cancer diagnosis is one of the main unmet needs in medicine, which can improve the unfavorable prognosis of patients. The potential of lipidomics has not been fully explored yet, because analytical workflows have limitations in terms of accurate molar quantitation and insufficient coverage of the lipidome. Biologists predict up to 100,000 lipid species in nature, but current methods typically report less than 1% of this number. Here, we will develop novel approaches for quantitation of more than 2,000 lipids from >80 classes using 13C stable isotope labeled internal standards and ultrahigh-resolution methods in liquid or supercritical fluid chromatography, mass spectrometry, and ion mobility. The comprehensive characterization of lipidome will allow us to construct Cancer Lipidome Atlas (WP1). We will develop new Bayesian software for automated data processing and statistical evaluation applicable to the main lipidomic and metabolomic workflows (WP2). We will correlate lipidomics data with metabolomics, proteomics, and transcriptomics data to unravel why lipidomic dysregulation in blood has a similar pattern for various cancers (WP3). This strategy will be applied for the comparison of ten types of cancer with control samples in cell lines, animal models (mice and pigs), human samples (tissues and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Not one but many: adopting structural flexibility in the analysis of the evolution of lncRNAs.' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Long non-coding RNAs (lncRNAs) are abundant in mammalian transcriptomes. However, it remains unclear how many of them are functional, and how their functions are performed. LncRNAs seem to be poorly conserved at the sequence level, but some of them share conserved structural elements and are present at syntenic genomic positions in different species. A recent study revealed that secondary structure constrains sequence variation in lncRNAs, so that polymorphisms are depleted in low accessibility regions and tend to be neutral with respect to structural stability. This is in contrast with previous analyses that dismissed relationships between structure and sequence evolution in lncRNAs. A crucial difference in the former study is that the considered structural feature, accessibility, is computed from an ensemble of thermodynamically stable structures. Moreover, high-throughput structure probing shows that many lncRNA sites exhibit positive signals for both single- and double-strand specific enzymes, suggesting several structures may coexist. Based on this, I argue that the difficulty of identifying links between sequence and structure in lncRNAs results in part from limitations imposed by assuming a single, stable structure. I thus propose to consider ensembles of co-existing structures in lncRNAs, and develop a new computational framework that enables this. Using this new paradigm, I will study lncRNAs from animals and fungi by coupling experimental data from RNA structure probing to novel computational approaches that overcome current limitations. Overall, this novel multidisciplinary approach will profoundly impact our understanding of the  evolution of lncRNAs. Furthermore, my project should help to fill the gap between structure and function of lncRNAs in different s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Outcomes of plant invasions in deadwood fungi and insect communities' (ENTWINE).

assistant: **Concept**

ENTWINE aims to understand whether and how invasive plants colonize new places, altering the structure of communities of fungus and insects linked with deadwood. The project integrates metabarcoding, phylogenetics, and community ecology to sample empirical and experimental communities that exploit native and invasive deadwood species in native and invaded forests throughout Lithuania. Exploiting long-read sequencing technologies and a bioinformatic pipeline to phase barcoding markers into Operational Taxonomic Units (OTUs), I will obtain normalised OTU richness and relative abundances and compare the β- species, phylogenetic, and functional diversity estimates between communities. Insects and fungi exploiting and living in deadwood form entwined communities that play a critical role in nutrient cycling, wood decomposition, and pathogen control. In addition to abiotic factors like local climate, biotic factors like deadwood species and decay stage influence the structure and strength of the associations with each other and their shared habitat. The abundance and quality of deadwood correlate with the local tree composition, which shifts as the invading Acer negundo spreads and outcompetes local Alnus glutinosa trees. Insect and fungi species turnover or variation in relative abundances might then result from e.g. the local extinction of rare specialists associated with A. glutinosa, the introduction of new species associated with A. negundo deadwood, and/or the increase in abundance of generalist species. Those changes in community structure resulting from A. negundo invasions may contribute to the loss of species and their ecological functions. This indicates the need to control the spread of invasive plants to prevent the extinction of vulnerable or rare species and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Efficient Synthesis of N-Heterocycles using Ynamides as Diazo Equivalents' (DIAZOFREE), addressing dissemination and exploitation.

assistant: **Impact**

Diazo groups are the most commonly used precursors for the controlled formation of very widely employed metal carbenes. However, the potential hazards associated with their use, coupled with the synthetic inefficiency and structural and functional group restrictions that are imposed from their installation, are limiting. This project is aimed at developing, studying and applying an alternative diazofree approach to access versatile metal carbenoid intermediates. New methodologies will result in valuable N-heterocyclic structures widely found in functional materials and many biologically active natural products, pharmaceuticals and agrochemicals. The proposed gold-catalysed novel transformations of ynamides will be combined with recent advances in copper catalysis for a short, efficient and general two-step synthetic strategy to prepare a wide variety of functionalised N-heterocycles from simple amine derivatives and (pseudo)alkynes. After establishing the reactivity concept, which will further the understanding of a new area of transition-metal catalysis, the wider synthetic applicability of this strategy will be explored. The potential value and impact of this method will be demonstrated to the wider synthetic community by its specific utility in target-led synthesis.Alongside the scientific impact of the research, the incorporated outreach activities will increase public awareness of the relevance of such research, generate enthusiasm in younger generations to pursue interest in science, and establish a generally accessible resource on gold catalysis. The skills and experience generated in this manner will complement the scientific leadership, communication and knowledge-transfer ability which will be established alongside the practical and intellectual skills and exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Japanese Ontology Interaction' (EUJOINT).

assistant: **Concept**

Uniting together four most prominent research centers acting at the intersection between engineering design, knowledge engineering, and philosophy of technology, EUJOINT will offer to Japanese and European researchers a unique opportunity for scientific exchange and focused cooperation on highly strategic, interdisciplinary projects. The four centres will exchange and integrate their knowledge with the goal of creating general engineering ontologies for technical products, accounting for functionality notions in a systematic, detailed, and cognitively transparent way. This goal is sought by focusing on four distinct yet interdependent objectives: (1) adoption of a common methodology for ontological analysis aiming at unifying core elements of the ontologies independently developed by members; (2) comparison and formalization of the various notions of role, action and agent exploited by members to capture product functionality; (3) clarification and formalization of the notions of artefact, device and product as employed in philosophy and in engineering design; (4) systematic study of the notion of engineering function (functionality), especially as used in engineering design, including the proper characterization of malfunctioning, and exchange of experiences on these and related notions in industry cases. EuJoint is unique since its members are internationally well known in their specialization areas and all embrace an interdisciplinary attitude that promotes interactions and synergies with groups in other disciplines. This shared attitude and the record of previous collaborations/meetings indicate the sincere commitment of each center to the programme and to an effective interaction. The centers are complementary concerning the knowledge needed and the objectives are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mimicry of host cell functions by microbial pathogens: subversion of ceramide signalling by a bacterial (Listeria) sphingomyelinase during intracellular infection' (Listeria).

assistant: **Concept**

Degradation of sphingomyelin (SM) by a sphingomyelinase (SMase) generates ceramide, a lipid metabolite increasingly recognised as an important pro-apoptotic mediator. The exact role of ceramide in apoptosis is unclear and aspects such as the source SM pool, and whether a membrane-associated neutral SMase (nSMase) or a lysosomal acid SMase is primarily involved, remain also to be defined. In this project, we will exploit the Listeria model of intracellular parasitism and an nSMase produced by these pathogenic bacteria, SmcL, identified and characterised in the host laboratory, to gain a better understanding of the role played by ceramide in host cell physiology, with particular emphasis on the apoptotic response. SmcL also provides a beautiful model to analyse how mimicry of host cell physiological functions by bacterial virulence factors contributes to the pathogenesis of infection.The host cell responses associated to SmcL-generated ceramide will be analysed during intracellular infection by using genome-wide transcriptome profiling and the specific pathways affected will be dissected by using a combination of molecular and cell biology techniques. Finally, we will also attempt to crystallise SmcL in collaboration with structural biologists. If successful, S mcL will become the first example of the neutral SMase family, a new group of SM-degrading enzymes comprising bacterial and eukaryotic orthologues with roles in virulence and signalling, to be characterised structurally.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Smart Catheterization'.

assistant: **Objectives**

Modern medicine is irreversibly shifting towards less invasive surgical procedures. Conventional open surgery approaches are systematically being replaced by interventions that reduce access trauma and thereby minimise pain and hospitalisation periods for patients. The downside of this approach is that it is highly demanding for the interventionalist, entailing unacceptable risks for the patient. In the perspective of patient safety, SCATh aims at minimizing these drawbacks specifically for a series of new and promising catheterization procedures. These procedures have the common denominator of dealing with cardiovascular disease, the main cause of death in the EU. SCATh will provide the interventionalist with visual and haptic tools for robust and accurate catheter guidance, which will be developed through novel approaches, by fusing preoperative patient-specific anatomical and mechanical models and intra-operative data streams from in situ sensors. By complementing and augmenting the skills of the interventionalist, patient safety will drastically increase and at the same time, potentially life-threatening complications which result from poor or damaging (x-ray, use of contrast agents) visualisation or poor surgical technique can be avoided. The new concept for tracking, sensing, modelling and manipulation of the surgical environment will be integrated with existing technological state-of-the-art in close cooperation with clinical experts and industrial partners, both in the design and in the evaluation phases. The common efforts delivered during this project will result in a demonstrator applied to a carefully selected set of catheter procedures. Moreover, many of the technological advancements created during SCATh touch upon minimally invasive surgical procedures in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The impact of highly magnetic neutron stars in the explosive and transient Universe' (MAGNESIA) targeting Horizon 2020.

assistant: **Abstract**

The gravitational wave window is now open. It is then imperative to build quantitative models of neutron stars that use all the available tracers to constrain fundamental physics at the highest densities and magnetic fields. The most magnetic neutron stars, the magnetars, have been recently suggested to be powering a large variety of explosive and transient events. The enormous rotational power at birth, and the magnetic energy they can release via large flares, put the magnetars in the (yet) hand-wavy interpretations of gamma-ray bursts, the early phases of double neutron star mergers, super-luminous supernovae, hypernovae, fast radio bursts, and ultra-luminous X-ray sources. However, despite knowing about 30 magnetars, we are lacking a census of how many we expect within the pulsar population, nor we have robust constraints on their flaring rates. The recent discovery of transient magnetars, of magnetar-like flares from sources with measured low dipolar magnetic fields and from typical radio pulsars, clearly showed that the magnetar census in our Galaxy is largely under-estimated. This hampers our understanding not only of the pulsar and magnetar populations, but also of them as possibly related to many of Universes explosive events. MAGNESIA will infer a sound Magnetar Census via an innovative approach that will build the first Pulsar Population Synthesis model able to cope with constraints/limits from multi-band observations, and taking into account 3D magnetic field evolution models and flaring rates for neutron stars. Combining expertise in multi-band observations, numerical modeling, nuclear physics, and computation, MAGNESIA will solve the physics, the observational systematic errors, and the computational challenges that inhibited previous works, to finally con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improvement of coals combustion-efficiency and decrease of harmful emissions under the influence of plasma' (ICEDHE) targeting Fifth Framework.

assistant: **Abstract**

The project 15 devoted to the solving of the problems of harmful emissions to the environment, reduced efficiency operation using poorer quality coals and relying on liquid fuel for light-up and to sustain flame stability for utility boileropreation. This aims are to be achieved through the implementation of thermo chemical plasma preparation for burning technology to provide improvements in all three areas. The work is an integration of theoretical ( thermodynamic and kinetic analyses and-D cod modelling) and experimental investigation ( in pilot and full scale combustion plant).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Ethics of Empty Beliefs: Chinese Buddhist Philosophy in the ‘Period of Disunity’', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Is it ethical to believe? CHINBUDDHPHIL will explore this basic yet troubling question by reconstructing what is a hitherto largely unstudied yet highly original philosophical conception of how belief relates to ethical action. Substantively, this project will constitute a major contribution to the historical and systematic study of Chinese Buddhist philosophy. It will accomplish this end through specialist research on the unduly neglected Sanlun school: A foundationally important movement active during a seminal period in the epochally transformative history of Buddhism in China. This will be the first comprehensive elaboration of Sanlun philosophy in any Western language. By placing Sanlun into debate with its Indian antecedents, later elaborations within Chinese Buddhism, and analogues in Western philosophy, this project will also forge multiple disciplinary innovations. Thus, within philosophy it will transform our understanding of philosophically valuable traditions by demonstrating that Chinese Buddhist philosophers merit consideration not only as historical artifacts but as genuinely interesting and insightful contributors to live philosophical problems. It will likewise redress the preponderant exclusion of Chinese perspectives from philosophically-oriented scholarship in Buddhist studies, and do so in a manner that bridges it with philologically-oriented Buddhology. And by investigating both the transmission of Indian Buddhist thought into China and its transformation once established there, it will revise the standard chronology of Chinese Buddhist philosophy, theorize India-China as a globalized sphere of dynamic intellectual interaction within trans-cultural Asian studies, and inform scholarship on cultural appropriation and assimilation, enculturation, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Ultra Fast Magnetic Resonance Imaging using One-Voxel-One-Coil Acquisition'.

assistant: **Objectives**

The proposal is aimed at the development of ultrafast Magnetic Resonance Imaging (MRI) for applications in neuroscience, neurology and oncology. The methodology used is based on the principle of one-voxel-one-coil acquisition in which the sensitive volumes of arrays containing a large number of small receiver coils is used as primary source of spatial localization. This allows to achieve acquisition speed >> 10 fps and opens up new windows of application for MRI. Within this proposal research will be aimed at two areas of application: For investigation of fast physiological events in the brain, applications based on the observation of fast spatiotemporal events by MR-encephalography (MREG) will be developed. MREG will be used for detailed quantitative measurement of differential cortical response during activation of cortical networks by complex stimuli. Primary areas of interest will be the investigation of spatiotemporal response in visual perception, visual and auditory cued tasks and during language processing. In addition to quantitative mapping of response, map functional connectivity with and without correlation with ECG will be investigated.  For neurological applications we will use the very high sensitivity of MREG to detect arterial pulsatility in order to generate quantitative, three-dimensional maps of hemodynamic function. Clinical applications for examination of patients with stroke, ischemia, vascular disease and vascular pathologies will be developed. The principles of OVOC-measurements will also be applied in oncology for measurements of fast intrinsic and stimulated physiological events like dynamic measurements of blood flow, tissue permeability and oxygenation in tumors and metastasis. Spectroscopic OVOC-measurements will be developed to observe met