RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NEW ADVANCED VACCINES IN CHRONIC HEPATITIS B' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Despite effective vaccines, hepatitis B virus (HBV) infection remains a major health problem with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a major risk factor for development of hepatocellular carcinoma (HCC). A new and efficient treatment against chronic infection and HCC is strongly needed, and therefore it is important to understand HBV replication and persistence. In the absence of a good model, woodchuck infection with woodchuck hepatitis virus (WHV) is used as the preferred system to study disease and by homology, HBV nature. In the present proposal we intent to establish a robust WHV reverse genetic system to study the virus replication and pathogenesis. By utilizing this WHV reverse genetic system, we plan to introduce two new strategies to generate virus-attenuated vaccines that could infect and interfere with wild type virus replication. WHV core is a structural protein required for virus replication and growth. We are proposing to construct a core deficient recombinant WHV that could replicate in wild type WHV infected cells, interfering  with wild type infection. A second strategy focuses on Hepatitis B virus X (HBx) and woodchuck hepatitis virus X (WHx) multifunctional proteins, which are required for optimal HBV and WHV replication and development of WHV derived HCC. We propose to create recombinant WHV with a mutant WHx protein that will interfere with  full-length protein activities if they are co-expressed. As an initial approach to study virus replication, we will utilize woodchuck hepatocyte xenograft transplants in RAG-1 transgenic mice. Finally, woodchuck animal model will be challenged to test the efficacy of recombinant viruses replication and interference with chronic infection and suppress HBV derive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Efficient odour representations in the olfactory bulb: Flexible lateral interactions synchronize co-active columns' to be submitted under Horizon Europe.

assistant: **Abstract**

How is the percept of a smell generated from the fractionated representation of odours at the periphery where olfactory receptor channels detect structural elements of odour molecules? While this problem seems akin to the detection of a “Gestalt”/object by the visual system using its contours, there is a fundamental difference between olfaction and vision due to the discontinuous, non-topographical nature of odour representation. Recently my group has discovered intriguing subcellular mechanisms of the neuronal microcircuits prevalent in the olfactory bulb that may enable flexible and energy-efficient non-topographical odour representation. These microcircuits connect distant olfactory receptor channel columns with each other and operate in a previously unknown activity-dependent manner. Here we aim to translate these findings from the synaptic to the systemic level, and test our hypotheses regarding the synchronization mechanism of co-active receptor channel columns in the gamma regime which will then allow the combinatorial synthesis of the odour percept in the olfactory cortex. By combining olfactory stimulation of our semi-intact nose-brain preparation with state-of-the-art imaging techniques with unprecedented large-scale spatio-temporal resolution (3D two-photon imaging of voltage-sensitive dyes), we will study the interaction between the neuronal ensembles belonging to columnar channels. This system-level understanding will be complemented by in-depth investigation of activity-dependent output of individual synapses in acute brain slices. Next, we will test whether columnar activity upon odour stimulation is amplified by a local mechanism recently discovered by our lab that links blood vessel pulsations to oscillatory neural activity. Finally, we will integrate o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative in-line Raman analytical sensor for new upstream cell culture monitoring and quality control' under Horizon 2020.

assistant: **Concept**

The main objective of the CellUp business innovation project is to develop and commercialize the new disruptive in-lineanalytics sensor for upstream cell culture process that the biopharmaceutical industry needs for the quality and processcontrol during the phases of process development, scale-up and manufacturing of vaccines and antibodies for humanmedicines based on eukaryote cells culture.This new bioprocess analyser will be the first industrial sensor able to perform in-line quantification of the main nutrients andmetabolites during the mammalian cell culture inside the bioreactor.Today, cell cultures in bioreactors are only monitored in real time with temperature, PH and Oxygen density sensors. Thenegative consequences of such a limited control are huge in terms of batch failures, time consumed at each scale-up phaseand in terms of untapped production yield improvement.Our company, with its unique integrated SWIFTS technology has the opportunity to fix the above described problem byoffering a high performance miniaturized in-line Raman analyzer which can be implemented as an industrial GMP sensor.Based on the needs expressed by several major industrial actors, the company has already developed a first productsuccessfully evaluated and released end of 2016 under the name ProCellics.The objective of the CellUp project is to go a step further in the integration of the Raman analyser thanks to a newconfiguration of our technology, called SWITS-CD. We will also develop a new “standard addition method” technology and arelated software to provide an easy and robust way to implement the monitoring of the cell culture. The key to the success ofthis new methodology development is a cell culture activity carried internally by our company.The total accessible market is estimat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Characterization of multi-species bacterial interactions underlying the beneficial symbiosis of a Mediterranean squid.' (SquidVibrio).

assistant: **Concept**

Animals often use associations with microbes to preserve their health. These mutualisms are maintained by host-microbe communication and though interactions between bacterial symbionts. The squid-vibrio symbiosis has been used for over 30 years to study beneficial host-microbe associations. However, nearly all studies of the symbiosis have used Euprymna scolopes and its only symbiont, Vibrio fischeri, which precludes examination of how multiple microbial species affect symbiosis. Using the squid Sepiola affinis, and its two symbionts, V. fischeri and Vibrio logei, the SquidVibrio project proposes to examine the effects of multiple microbial species within a mutualism. The project is organized into three objectives. 1) Implement a husbandry facility for S. affinis. 2) Quantify the symbiont populations within the S. affinis light organ over seasons and over maturation. 3) Identify how the symbiont populations alter metabolites within the light organ. First, a husbandry facility will be established at the Banyuls-sur-Mer Oceanographic Observatory that will allow for the maintenance of wild S. affinis and for rearing of the squid. Second, metagenomics will be used to estimate the proportions of V. fischeri and V. logei within the light organ. Subsequently, light organs of field-caught and reared squid will be imaged using confocal microscopy to identify if the Vibrio spp. inhabit mixed or distinct niches. The third objective will use LC-MS and mass spectrometry imaging to identify metabolites that are altered by each Vibrio spp. and how localization patterns of these molecules are affected. These methods will allow for the two-way transfer of knowledge, with the researcher providing squid husbandry techniques and the host institution providing genomics and metabolomics. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Scientific societies and the globalization of science (1930-1990)' (1930-1990).

assistant: **Innovation**

Science has become a global enterprise. To produce knowledge, scientists with different nationalities, gender backgrounds, ethnicities and socio-political views engage in debate and adopt shared codes of conduct (e.g. leaving out personal bias when evaluating each other’s work). This project conducts historical research into the mechanisms that structure these global social relations within science by using 20th century scientific societies as its lens. It hypothesizes that these hitherto unstudied societies have played a regulatory role in the globalization of science by acting as ‘gatekeepers’, simultaneously opening up and limiting access to (sub)groups, such as women scholars or scholars from the Global South, by organizing (massive) conferences, selecting speakers, allocating prizes, electing boards etc. Building on studies of gender and ethnicity in science and on sociological analyses of evaluation in science, GLOBAL ACADEMIES innovates the concept of scientific sociability to include unspoken codes of conduct that could establish divisions within scientific groups, allowing the study of societies’ mechanisms of in- and exclusion, of setting (implicit) standards, and their strategies for coping with (political) dissent. The project innovates methodologically by engaging in multi-sited research into scientific societies in the USA, France, India and Brazil, and at the international level, and by using multiple research methods (journal analysis, archival research and oral history), in which present-day scientific societies are involved as stakeholders. The project aims (1) to develop a conceptual toolkit for scholars across the humanities and social sciences to understand scientific societies’ formats, standards and customs in relation to scientists’ group behavio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Greenhouse gases to valuable liquid chemicals:  High-flux zeolite membrane-based reactor for the efficient conversion of CH4 and CO2' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Both methane (CH4) and carbon dioxide (CO2) are greenhouse gases, but are available in large supply, and are often flared or vented. A promising strategy to efficiently utilize these abundant molecules is their transformation to easily transported liquid chemicals, which is particularly attractive because this conversion not only reduces emissions of the greenhouse gases into the atmosphere, but also produces commodity chemicals that can be either used as fuels or as precursors for many industrial processes. We propose the fabrication of a prototype membrane reactor, containing catalytically active, highly oriented zeolite ZSM-5 thin-films for the conversion of CO2 and CH4. We have recently demonstrated a method for fabricating catalytically active, highly oriented thin-films of zeolite ZSM-5 on various dense substrates. In this Proof of Concept proposal, we will develop the fabrication of zeolite ZSM-5 thin-films on porous substrates to serve as membranes for catalysis and to convert CH4 and CO2 into liquid commodity chemicals, especially aromatics. The membranes will be incorporated into a prototype reactor, to be designed and implemented as part of the proposal, for reaction testing and optimization. Along with the experimental work we will create a market analysis and seek potential industrial partners, key to this will be pursuing intellectual property coverage through a patent application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Democracy, Autocracy, and International Cooperation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

One of the most consistent findings in the study of world politics is the positive relationship between democratic regimes and international cooperation. Yet events in recent years suggest a more complicated picture. Several democracies have withered in their support for international organizations, while autocracies simultaneously have stepped up their commitments to cooperation. This project will use recent developments as a backdrop for launching a new research agenda on the relationship between regime type and international cooperation. Guided by the over-arching question of why, how, and under what conditions regime type affects international cooperation, this project will conduct the most systematic and comprehensive analysis so far of this relationship. Theoretically, it will break new ground by developing a novel framework for identifying how regime type may have varying and conditional effects on international cooperation. Empirically, it will be more comprehensive than any previous research effort, examining this relationship over a longer time period and across a broader range of international cooperation, based on an extensive new data collection. Methodologically, it will leverage an ambitious multi-method design, combining large-N statistical analysis, experimental analysis, and in-depth case analysis in a complementary fashion and with a comparative orientation. In addition, the project will be policy relevant by generating insights on the resilience (or not) of international cooperation in an age of democratic decline.


**Keywords:** democracy, autocracy, regime type, international cooperation, international organization, multi-method
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Differentiation and role of Natural Killer cell subsets'.

assistant: **Concept**

NK cells are innate lymphocytes that play a role in the early response against intracellular pathogens and against tumors. Several NK cell subsets have been described in peripheral organs that correspond to discrete stages of in vivo maturation. How NK cells differentiate from early precursors and what are the specific functions of each NK cell subset are unresolved issues. Here, we propose a three-aim program to address these questions. First, we want to revisit the partition of the NK cell population that is currently based on surface markers of undefined function by looking at the expression of transcription factors (TF) essential for NK cell development and maturation, such as T-bet and Eomes, using novel TF reporter mice. This strategy should also allow us to identify very early steps of NK cell development (NK cell progenitors) that remain ill defined. Second, we will try and identify molecular mechanisms that induce transition between NK cell maturation stages. For this we will take advantage of a previous gene profiling analysis that pointed at several pathways and TF that were highly regulated during NK cell maturation. The role of these pathways and TF in the differentiation of NK cells will be measured using a novel Cre/lox system allowing NK-specific gene deletion. Detailed analysis of mouse mutants will be used to delineate the role of selected genes and pathways in NK cell differentiation. Third, we will compare patterns of migration, cytokine secretion, in vivo cytotoxicity and global gene expression by individual NK cell subsets during an airway infection by Influenza to get insight on the specific functions of NK cell subsets during immune responses. Altogether, the results of this study should provide developmental, molecular and functional evidences t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Researchers' Night in Sweden - ForskarFredag 2008' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Researchers’ Night in Sweden, ForskarFredag (Researchers´ Friday), FF, consists of twelve events and three associated events in seventeen cities, dispersed geographically over Sweden. The project aims at bringing the broad public face-to-face with researchers. FF will be organised on 26 September 2008 and is coordinated by Vetenskap & Allmänhet (Public & Science), as in 2006 and 2007. Project partners are universities, science centres, municipalities and a regional council, all organising a local FF event. The project is facilitated by the partners’ wide-ranging and diverse links within industry, academia, research disciplines and topics.  The objective of the innovative and exciting activities offered at each event is to allow for public engagement and meetings with researchers in a relaxed and festive environment. Fun, hands-on and interactive activities as well as informal dialogues on topical issues will help attracting the broad public, especially those not specifically interested in research. The fact that research is all about communication and international cooperation, especially on a European level, is emphasised.  The number of estimated visitors is at least 14,000. Live media reports and news items are also expected to cover the events. Furthermore, everyone will be invited to take part in the European photo competition and to make a pledge to reduce personal carbon dioxide emissions by “clicking for the climate” on the project website.   To ensure maximum visibility, a coordinated awareness campaign will be implemented. Impact will be assessed and FF results and best practice will be disseminated through the participants´ networks and at national and international conferences.  Unanimous objectives, similarity of contents as well as a joint website will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Accessing hot-spots in plasmonic nanoantennas' (HOTSPOT), addressing dissemination and exploitation.

assistant: **Impact**

Guiding molecules/nanomaterials to the right place in plasmonic nanoantennas is a key problem to be solved in order to benefit from the high electromagnetic field localization offered by these materials. Accessing these nanoscale-regions remains a significant challenge in plasmonics and is the main goal of this project. The novel approach introduced here is based on the field-enhancement properties of the nanoantennas, thus spatially selective to the hot-spots. This easy, fast and cheap strategy can allow selective and large-scale positioning of any kind of molecules and/or nanomaterials in a variety of plasmonic-nanoantenna hot-spots, independently of their shape and resonance position. This strategy can solve the big challenge of hot-spot modification in plasmonic nanoantennas thus opening new doors to many real applications ranging from biosensing to energy conversion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Chemometrical treatment of toxic compounds-endocrine disrupters'.

assistant: **Objectives**

Post-graduate (post-doc) Marie Curie fellowship available. The topic of the research training is the study of molecular structures - biological activity relationship. The biological activities related to endocrine disruption will be considered. Different computer programs for treatment of molecular structures, for calculation of various molecular descriptors, and for different modeling methods are available. A mentorship and training in quantum chemistry, calculation of descriptors and chemo metrics on pre- or post-doc level is offered to fellows. The fellows are encouraged to the intensive use of Internet, Web of Science and on-line libraries, and also to follow the EU Commission regulations regarding the endocrine disrupters. A solid knowledge of computational chemistry and enthusiasm to work with computers is required. The team of the research group offers a pleasant working atmosphere, with many intra-laboratory and international connections.