RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Water resource strategies and drought alleviation in Western Balkan agriculture'.

assistant: **Innovation**

4 EU and 3 WB partners will provide strategies for managing water resources for WB by combining modern technologies from a river basin through to single plant, taking account of environmental, socio-economic and health implications, studying: -river flo w, evaporation, rainfall patterns, runoff, water availability, using geographical information systems to categorise 3 areas, -water quality and nutrient use in relation to eutrophication, microbiological hazards and ecotoxicology on the farm, -micrometeor ological studies to monitor, model and predict water/nutrient use in the field, -irrigation techniques for improving plant/crop WUE, -the commerciality of quinoa, -socio-economic parameters analysing different management strategies and implications for irr igation, reducing crop water demands, and an alternative crop. A Land-Water-Economic Information System will be created and applied to 3 river basins to represent local and regional water sources, sources of contaminated runoff, agricultural water use, a nd likely impacts of farmer uptake of new water use/treatment technology. Modelling results and trials on water/nutrient use with a various crops will be tested on local farms. Workpackages are Water quantity, Water quality, Crop water use, Socio-economi cs and Dissemination. The project will deliver procedures for strategic water management, models of water/nutrient use, irrigation methods, confidence in GIS construction/usage, and outreach of modelling resources for WB.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'European Control System Security Incident Analysis Network'.

assistant: **Objectives**

The protection of critical infrastructures increasingly demands solutions which support incident detection and management at the levels of individual CI, across CIs which are depending on each other, and across borders. An approach is required which really integrates functionalities across all these levels. Cooperation of privately operated CIs and public bodies (governments and EU) is difficult but mandatory. After about 10 years of analysis and research on partial effects in CIP and for individual infrastructure sectors, ECOSSIAN is supposed to be the first attempt to develop this holistic system in the sense portrayed above. A prototype system will be developed which facilitates preventive functions like threat monitoring, early indicator and real threat detection, alerting, support of threat mitigation and disaster management. In the technical architecture with an operations centre and the interfaces to legacy systems (e.g., SCADA), advanced technologies need to be integrated, including fast data aggregation and fusion, visualization of the situation, planning and decision support, and flexible networks for information sharing and coordination support, and the connection of local operations centres. This system will only be successful, if the technical solutions will be complemented by an effective and agreed organizational concept and the implementation of novel rules and regulations. And finally, the large spectrum of economically intangible factors will have significant influence on the quality and acceptance of the system. These factors of societal perception and appreciation, the existing and required legal framework, questions of information security and implications on privacy will be analyzed, assessed and regarded in the concept. The system will be tested,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Investigating Ror2-dependent non-canonical Wnt signaling in bone remodeling' (ROR2BONE) under Horizon 2020.

assistant: **Objectives**

Wnt signaling is composed of the canonical and non-canonical pathways. Canonical Wnt signaling is dependent on β-catenin activation and has become a major focus for targeting osteoblast-mediated bone formation in the context of treating the debilitating disease osteoporosis. However, much less is known about the role of the non-canonical pathway in bone formation. Unpublished data of the host laboratory demonstrates that targeted deletion of the non-canonical Wnt signaling Receptor tyrosine kinase-like orphan receptor 2 (Ror2) in osteoblasts in mice causes a high bone turnover with increased bone formation and enhanced osteoclast-mediated bone resorption. I thus hypothesize that Ror2 regulates bone remodeling by altering signaling in osteoblasts and their interaction with osteoclasts. In Aim I, I will determine cell autonomous effects of Ror2 on osteoblasts by analyzing cell differentiation, proliferation, survival, and by performing functional studies both in vitro and in vivo. Additionally, since osteoblasts provide pro- and anti-differentiation signals to osteoclasts, Aim I will further explore if Ror2 alters the activity of these signals and investigate the resulting phenotypic changes in osteoclast function. In Aim II, I will undertake an in-depth experimental approach combined with an innovative bioinformatics analysis to investigate the osteoblast-specific non-canonical Wnt signaling cascade downstream of Ror2 after reconstituting Ror2-deficient cells with wild type or Ror2 mutants. Lastly, in Aim III I will directly address the therapeutic potential of Ror2 in several in vivo bone turnover models utilizing a chimeric Ror2-Fc soluble receptor. In summary, I will use state of the art in vivo and in vitro approaches to delineate the downstream Ror2 signaling cascad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Record-keeping, fiscal reform, and the rise of institutional accountability in late-medieval Savoy: a source-oriented approach' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The present research project focuses on an unjustly neglected corpus of late-medieval sources, the administrative and fiscal accounts (‘computi’) of the castellanies – basic administrative units – of the county of Savoy. I propose a holistic model of analysis that can fully capitalise on the unusual wealth of detail of the Savoyard source material, in order to illuminate some key topics in late-medieval institutional and socio-economic history, from the development of state institutions through administrative and fiscal reform – with particular attention to the transition from personal to institutional accountability – to the question of socio-economic growth, decline, and recovery during the turbulent period of the late-thirteenth to the late-fourteenth century. More broadly, my research into these topics aims to contribute to our understanding of the late-medieval origins of European modernity. The advances of pragmatic literacy, record-keeping, and auditing practices will be analysed with the aid of anthropological and social scientific theories of practice. By comparing the Savoyard ‘computi’ with their sources of inspiration, from the Anglo-Norman pipe rolls to the Catalan fiscal records, the project aims to highlight the creative adaptation of imported administrative models, and thus to contribute to our knowledge of institutional transfers in European history. The project will develop an inclusive frame of analysis in which the ‘computi’ will be read against the evidence from enfeoffment charters, castellany surveys (‘extente’), and the records of direct taxation (‘subsidia’). The serial data will be analysed by building a database; the findings of quantitative analysis will be verified by case studies of the individuals and families (many from the middle social
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Challenging and extending predictive coding as an account of brain function' (EXPC).

assistant: **Concept**

Probabilistic models of brain function, which propose that the brain can be understood as implementing the principles of optimal statistical inference, have become extremely influential in recent years. Predictive coding is perhaps the most widely held, and best supported, of these models, particularly within cognitive neuroscience. However, current models of predictive coding and its neuronal substrates are still relatively simple, and do not explain how humans solve a number of fundamental problems. This limits their power to explain brain function. I propose a series of experiments designed to test how human subjects address a number of these core problems. I will use behavioural and neuroimaging data to develop and test extensions to current models (or, if necessary, provide an alternative framework for understanding brain function). The purpose of this is two-fold, to give insight into the computations that underlie cognitive function, and to provide understanding of the neurobiological processes that support those computations. The project will thus constitute a stepping stone towards developing a mechanistic model of how the brain implements cognition.


**Keywords:** Predictive coding,  Bayesian brain,  neuroimaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fouling resistant ceramic honeycomb nanofilters for efficient water treatment' under Seventh Framework.

assistant: **Concept**

The main challenge of the proposed project is the development of a ceramic honeycomb nanofiltration membrane with strongly increased membrane area of up to 25 m². The strongly increased membrane area in comparison with existing ceramic membranes for nanofiltration in combination with a high surface to volume ratio shall be competitive with polymeric membranes in terms of economics. The nanofiltration coating will allow for instance the direct filtration of surface water for drinking water preparation by a “low volume, low energy” filtration process. The low fouling tendency of the ceramic material will lead to low operating costs and reduced membrane down time during membrane cleaning. The high mechanical stability enables high pressure back-flushing of the membranes. The high chemical and thermal stability of the membrane material allows the chemical or thermal regeneration and sterilization by aggressive chemicals or hot steam if needed. Furthermore ceramic membranes shows considerably higher permeate fluxes in comparison to polymeric membranes. In addition to the high permeability and a low fouling tendency the membranes can be operated at low transmembrane pressures and low cross flow velocities. This strategy helps to reduce operation costs and save energy (“low feed, low pressure”).The proposed project will address a crucial point in terms of a more extended use of membrane filtration technologies in water purification: the ratio between active filtration surface and module size. Besides overall ordinary requirements in membrane filtration like long term stability, appropriate membrane price, high selectivity, high flux/pressure ratio, low energy demand for cross-flow-filtration and low membrane cleaning frequency this parameter will be of vital importance for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

CRISPR-Cas loci are the adaptive immune system of archaea and bacteria. They can capture pieces of invading DNA and use this information to degrade target DNA through the action of RNA-guided nucleases. The consequences of DNA cleavage by Cas nucleases, i.e. how breaks are processed and whether they can be repaired, remains to be investigated.  A better understanding of the interplay between DNA repair and CRISPR-Cas is critical both to shed light on the evolution and biology of these fascinating systems and for the development of biotechnological tools based on Cas nucleases. CRISPR systems have indeed become a popular tool to edit Eukaryotic genomes. The strategies employed take advantage of different DNA repair pathways to introduce mutations upon DNA cleavage. In bacteria however, the introduction of breaks by Cas nucleases in the chromosome has been described to kill the cell. Preliminary data indicates that this might not always be the case and that some DNA repair pathways could compete with CRISPR immunity allowing cells to survive. Using a combination of bioinformatics and genetics approaches we will investigate the interplay between CRISPR and DNA repair in bacteria with a particular focus on the widely used CRISPR-Cas9 system. The knowledge gained from this study will then help us develop novel tools for bacterial genome engineering. In particular we will introduce a NHEJ pathway in E.coli making it possible to perform CRISPR knockout screens. Finally using CRISPR libraries and multiplexed targeting, we will generate for the first time all combinations of pair-wise gene knockouts in an organism, a task that for now remains elusive, even for large consortiums and with the use of automation. This will enable to decipher genome-scale genetic interaction networks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Danish HPCN technology transfer node' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The DANHIT TTN will initially concentrate on the following main themes, selected from areas where the Danish community is particularly strong: Bioinformatics, in close collaboration with the BIOTITAN TTN, e.g. genetic analysis of selected traits in animal populations. Flexible manufacturing technology with a focus on advanced industrial robots for short or complex productions runs. Environmental studies with a focus on airborn pollution models. The medical sector, e.g. anaesthesia simulation and design of human prostheses. Aerodynamic analysis of airflow impact, e.g. aerolastic bridge stability simulation and design of wind rotor blades.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Empire, classical history and world discoveries. Uses of classical scholarship in sixteenth- and seventeenth-century Portuguese expansion.""' (EMPIRECLASICS) under Seventh Framework.

assistant: **Objectives**

This project will investigate the uses of classical antiquity in the discovery, perception and incorporation of the extra-European realities of the early modern Portuguese empire. It will analyse the phenomenon from a markedly broad perspective, comparing it to the Spanish, British, and Dutch experiences overseas. The project will analyse the presence and meanings of classical referents in both written and visual representations of worlds overseas (historical accounts, geographic descriptions, images of “conquerors” “natives” and ultramarine territories...). Three specific areas of interest will be examined. The first is the utilization of the classics for anthropological description, and for reflecting on social institutions and customs. The second concerns their use as a narrative model, a pattern for personal action, and a rhetorical resource. The third is the influence of classical sources in developing an overarching political and historical interpretation of the discoveries, and the ways in which this contributed to a reassessment of the Portuguese and European past and historical consciousness.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advancing Data-Based Policy-Making in Urban and Regional Development and Wide-Scale Implementation for Sustainable Environments' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

UR-WISE aims to achieve long-term excellence, institutional recognition, visibility, and better integration of the host institution (FEUN) in the European Research Area. Led by ERA Chair holder, the project seeks to foster competitiveness in research funding by promoting institutional reforms at both system and organisational level. It aims to establish a permanent and excellent research group in the field of data-based policy analytics for resilient urban and regional development. This is to be achieved through clearly defined and measurable specific objectives: Establish an excellent research group fostering brain circulation and inter-sectoral mobility to create brain gain for FEUN, by increasing the number of R&I professionals relocated to ERA team and placing a strong emphasis on international, interdisciplinary and intersectoral mobility; Implement structural changes at FEUN to enhance its institutional framework by joining international networks and associations, forming alliances with economic faculties, and establishing partnerships with research-intensive institutions; Increase FEUNs research excellence and profile in data-driven policy analytics through training opportunities, mentorship programs and collaboration with global partners; Enact organisational changes to enhance contributions to knowledge-based economy and secure competitive research funds by upgrading research infrastructure, founding research institute, and forming partnerships with technology park; Conduct a series of research to enhance FEUN's capacity for policy advising at local and national levels, by utilising a multifaceted methodology integrating spatial analysis, citizen engagement and multidimensional evaluation techniques.The project leverages the ERA Chair holder's international net
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of transcription factor, ets2, in inhibiting programmed cell death - apoptosis', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content Ets2 is a transcription factor regulating the expression of genes involved in cell growth, differentiation and developmental processes. Unpublished results from Dr. Boulukos' laboratory show that Ets2 can also inhibit programmed cell death (apoptosis). This is the first observation indicating that Ets2 can play a role in controlling cell death processes. They observe that while macrophages die by apoptosis in the absence of macrophage colony stimulating factor (CSF-1), a factor necessary for the growth and survival of myeloid cells, macrophages constitutively expressing Ets2 survive under the same conditions. I propose to investigate whether this inhibition of programmed cell death by Ets2 is a general phenomenon. Two different cellular systems available in the laboratory will be used to address this question. I will develop a third cellular system where Ets2 expression will be inducible. This system will be used to determine at what point(s) Ets2 expression is necessary to inhibit the initiation of the cell death program. Finally, I will investigate the mechanism of inhibition of apoptosis by Ets2. Several genes are implicated in controlling cell death. I am interested in determining whether one or several of these genes are direct downstream targets of Ets2. Training content (objective, benefit and expected impact) I chose Dr. Boulukos' laboratory because I want to obtain in experience in a new and exciting field of research. My objectives are to learn about a transcription factor which not only induces macrophage differentiation, but also controls the cell death program. I will clearly benefit by learning the current techniques used in molecular and cell biology including cloning, sequencing, Northern and Western analyses, cell transfe