RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative and safe microwave-based imaging technology to make breast cancer screening more accurate, inclusive and female-friendly' (MammoScreen).

assistant: **Innovation**

Breast cancer (BC) is the most common cancer in women worldwide, affecting 1 in 8 women. The figures from WHO’s International Agency for Research on Cancer estimate that in 2020 worldwide cases of breast cancer accounted for 24% of all cancers in women (2.26 million women and 685,000 deaths globally). Mammography is the gold standard technology for breast screening, which has been demonstrated through different randomized controlled trials to reduce breast cancer mortality. However, it has limitations and potential harms, such as the use of ionizing radiation, breast compression and performance restrictions due to the intrinsic nature of X-rays. In particular, breast density is a restrictive property that can prevent breast cancer detection in mammograms of women with radiographically dense breasts. Other existing techniques (MRI, Ultrasound, biopsy) also suffer from drawbacks. The overall aim of the MammoScreen proposal is to generate evidence about the use of MammoWave (a technology developed by UBT) as screening technique in population-based programs promoted by National or Regional Health Systems, to reach a revolution in breast screening. To do so, the consortium aims to confirm that MammoWave reaches sensitivity>90% and specificity>95% in BC detection on 10000 study participants undergoing regular screening programs. MammoWave uses safe non-invasive and non-ionizing microwave signals, does not apply any compression to the breast and is very effective with dense breasts. Hence it can extend the breast screening to younger women aged 20-49 (98 million women in Europe). This group accounts for ~30% of breast cancers in 2020. A comprehensive health economic assessment will be undertaken in this project and innovative way to implement patient engagement approaches is s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Living Image of Sherlock Holmes: The Cult of Celebrity in the Age of Disenchantment' (LISHCCAD).

assistant: **Concept**

My project, ‘The Living Image of Sherlock Holmes: The Cult of Celebrity in the Age of Disenchantment,’ aims to recast our understanding of nineteenth-century ideas and practices of celebrity, expertise and truth as well as the drive toward what U.S. historian James Cook calls ‘disenchantment’ in the realms of both science and magic alike (Arts of Deception 180). Anchored in William Gillette’s immensely successful 1899 production and performance of Sherlock Holmes, my project situates the late Victorian cult of celebrity in relation to competing models of inquiry and the wide array of edifying entertainments. Gillette’s Holmes – his twice over, as he both penned the adaptation and performed the role – was a staggering cultural phenomenon, played for decades across the globe. As a result, the performer/character offers a unique and critical means by which to understand these pivotal issues in the period. It is a timely project which will have a major impact on the fields of celebrity studies, theatre history, Victorian studies and the history of science, for it not only rethinks the most pressing concerns of the Victorian period but also illuminates our own. Because so many of the late nineteenth-century anxieties – the increasing importance of celebrity, the pace of technological development and the status of experts and the role of expertise, to name just a few – remain our anxieties, a thorough interrogation of their world enables us to better understand ours.Keywords: theatricality, celebrity, detection, Sherlock Holmes, William Gillette, entertainment, science, nineteenth century, Victorian, melodrama


**Keywords:** Theatre history,  celebrity studies,  Sherlock Holmes,  performance,  magic,  detectives
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Memory loss in Alzheimer disease: underlying mechanisms and therapeutic targets', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

MEMOSAD aims at defining the molecular mechanisms of Abeta- and Tau-induced synaptotoxicity and at developing disease-modifying therapeutics for the prevention of memory loss in Alzheimer disease (AD). Insoluble aggregates of the two proteins provide the pathological hallmarks of this incurable brain disorder. Early stage AD is characterized by a remarkably pure impairment of declarative memory and several lines of evidence suggest that this memory impairment is independent of the insoluble aggregates, does not require neuronal death and is caused by subtle and transient synaptic changes. The toxic Abeta and Tau species that cause synaptic dysfunction, their mechanism of toxicity and the link between both pathologies remain largely unknown, but recent data suggest that Abeta accumulation triggers Tau pathology.  Consequently, primary neuronal cultures and animal models (C.elegans,zebrafish,mouse) will be employed to define the pathologic pathways leading from Abeta through Tau to synaptotoxicity. Initial experiments will investigate the effect of well-defined Abeta species on long term potentiation, synaptic morphology, gene expression, Tau phosphorylation/aggregation, axonal transport and behaviour. Similarly, we will investigate the functional consequences of Tau misfunction, aggregation, hyperphosphorylation and missorting in various cell culture systems (retinal ganglion cells, primary hippocampal neurons, organotypical slices) and animal models, especially with regard to intraneuronal trafficking and synaptic function. Once the toxic Abeta and Tau species are known and their mechanism of toxicity are defined, we will investigate how these pathways interact. Unravelling the pathologic pathways that lead from Abeta through Tau to synaptotoxicity and memory loss shoul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Information system for the ESF/QUEEN Programme' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

RTD actions implementing ENRICH are part of accompanying measures of the Environment and Climate Programme, the Marine Science and Technology Programme and the International Cooperation Programme. CORDIS generally does not held information on accompanying measures of RTD programmes. Therefore for further details please contact: Ib Troen, European Commission, DGXII.D.I at ib.troen@ec.europa.eu.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Predicting the effects of environmental change on freshwater fish production', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The chief objectives of this four-year project were:(i) To examine the thermal metabolic performance of selected freshwater fish species that provide sustainable fisheries of economic importance, and to develop growth models, based on water temperature, food consumption and fish size, that can predict changes in growth as a result of environmental change. The target species were brown trout, including sea-trout (Salmo trutta L.), Atlantic salmon (Salmo salar L.), Arctic charr (Salvelinus alpinus (L.)) and perch (Perca fluviatilis L.).(ii) To study intraspecific variation in thermal performance along latitudinal and climatic clines, to evaluate possible responses to persistent temperature changes among economically important species, and determine geographical variation in several metabolic traits that may influence fish production.In conclusion, experiments on a total of 37 populations of four species, and field studies on 63 populations of two salmonid species, provided no clear-cut evidence for either of the two hypotheses on thermal adaptation. Hence, one important question remained to be answered: why did none of the four target species show evidence for thermal adaptation? It was concluded that: (i) trade-offs may exist between growth and phylogeny, limiting the possibility for thermal adaptation; (ii) there may be no, or very little, genetic variability for the traits in question because selection favours phenotypic plasticity rather than local adaptation. Finally, it is also evident from the present experiments that several populations should be explored before strong inference is made about thermal adaptations. As this project has progressed, adaptive patterns have emerged, and disappeared again, as new populations were included in the experiments. Several combi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Nonlinear spatiotemporal light bullets: origin and stability'.

assistant: **Objectives**

The NOSTER project is about unveiling the dynamics and features of spatiotemporal coherent structures emerging in multimode optical fibers, such as spatiotemporal solitons, also known as light bullets.  Solitons are particle-like states, emerging due to a double balance between linear and nonlinear processes, that maintain their shape while propagating in a medium. Solitons arise in a large variety of different natural media, ranging from hydrodynamics and plasma physics, to nonlinear optics and biology. In nonlinear optics, the emergence of solitons is related to the light confinement in time or space.  One basic example of a system yielding to this type of state are single mode optical fibers, where the Kerr nonlinearity counteracts the spreading of the light produced by the chromatic dispersion. In multimode optical fibers, temporal and spatial effects, such as chromatic dispersion and diffraction, can occur simultaneously and counteract the Kerr nonlinearity, leading to the space-time confinement of light, and therefore, to the formation of much more complex coherent structures. My approach in this project is to predict and analyze the generation of localized spatiotemporal states, in particular light bullets and vortices, from a pattern forming and bifurcation theory perspective. Applying advanced analytical and numerical methods, I will first elucidate the origin of light bullets,  characterizing  their  dynamics and bifurcation structure. In a second step, I will study the dynamical properties of optical vortices and the potential transition to optical turbulence. In both cases, their interaction dynamics, and the influence of high-order effects and losses will be analyzed. The understanding of such complex dynamics is crucial, and it will enable a tremendous bre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Controlling Tunneling Charge Transport with Organic Synthesis' to be submitted under Seventh Framework.

assistant: **Abstract**

This project pushes Molecular Electronics (ME) beyond simple distant-dependence studies towards controlling tunneling charge transport with organic synthesis by manipulating the intrinsic properties of organic molecules to shape the tunneling barrier. The measurements will be done with two tools that I have developed; Eutectic Ga-In (EGaIn), which is increasingly being used by the ME community as a robust method for measuring charge-transport through self-assembled monolayers (SAMs) and SAM-templated nanogap (STAN) electrodes, which is a newer tool that allows the facile coupling of light and electric fields into SAM-based tunneling junctions. These tools are critical for performing physical-organic studies in practical tunneling junctions in which the molecules themselves define the smallest dimension of the junction; spectroscopic tools that rely on AFM or STM define the junction with a piezo and are not directly applicable to practical devices, which is the underlying motivation for all research in ME.Two sets of molecules, one cross-conjugated and one combining flexible alkane tails with rigid oligophenylene moieties will be synthesized and investigated; more as necessary. Both series of molecules are designed around straightforward physical-organic studies meant to elucidate structure/property relationships empirically by measuring the influence of systematic structural/electronic changes on the electrical properties of tunneling junctions. The molecules will be incorporated into both EGaIn and STAN junctions to unravel the effects of the energies of the frontier orbitals, dipole moments, and other non-length-dependent synthetic handles. In the STAN junctions, the molecules will be gated with electric fields to examine more closely dynamic shifts in orbital energie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Long Arms of Authoritarian States', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

What strategies do authoritarian states deploy to control information beyond their borders? While disinformation efforts as foreign influence has received extensive attention, little has been done to systematically dissect information suppression strategies. By analysing the ways in which Russia, China, Ethiopia and Rwanda suppress information, the ARM project will conceptualise, identify and help address information suppression as foreign information manipulation and intervention (FIMI) by authoritarian states domestically, within Europe, and among diaspora communities residing in Europe. China and Russia are selected as two major powers highly active in managing information as a part of their foreign policy. Ethiopia and Rwanda, though less influential on the global stage, are some of the most engaged African states in transnational repression. Having substantial diaspora populations in Europe, their reach should be analysed and the implications of their information suppression should be understood. By conceptualising information suppression as part of FIMI, the ARM project will broaden the established approach to FIMI, which has traditionally only been focused on disinformation. By delineating the concept of information suppression within the strategic toolbox of authoritarian regimes, we will contribute to the scholarly discussions how autocracies manoeuvre to strengthen their power base. With the identification of the tactics, techniques, and procedures of information suppression, we will make a toolkit, including recommendations on how to combat information suppression operations, taking the risks and vulnerabilities of target groups into consideration. Through the lifespan of the project, we will involve the defender community: key actors within policy and civil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Centre for urban construction and rehabilitation: technology transfer, research and education' (CURE).

assistant: **Concept**

The proposal concerns the request for a financial support for the Centre for Urban Construction and Rehabilitation located at the Faculty of Civil Engineering, Technical University of Gdansk, Poland. The proposal objectives for the Centre are: technology transfer, research and education; building of network with EU Centres; extension of co-operation with Eastern Europe i construction of national network; support for economic and social needs ; enhanced participation in the European Programmes; attracting young researchers and building capacity of the Centre. In order to achieve these objectives the following work packages have been proposed: extending PhD studies into international level; organising postgraduate studies, summer schools and Courses of EUROCODES; organising international conferences and thematic workshops; conducting: study visits, networking and twinning activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Dynamic interplay between DNA methylation, histone modifications and super enhancer activity in normal T cells and during malignant T cell transformation'.

assistant: **Innovation**

Dynamic interplay between histone modifications and DNA methylation defines the chromatin structure of the humane genome and serves as a conceptual framework to understand transcriptional regulation in normal development and human disease. The ultimate goal of this research proposal is to study the chromatin architecture during normal and malignant T cell differentiation in order to define how DNA methylation drives oncogenic gene expression as a novel concept in cancer research.T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric and 25% of adult ALL cases and was originally identified as a highly aggressive tumor entity. T-ALL therapy has been intensified leading to gradual improvements in survival. However, 20% of pediatric and 50% of adult T-ALL cases still relapse and ultimately die because of refractory disease. Research efforts have unravelled the complex genetic basis of T-ALL but failed to identify new promising targets for precision therapy. Recent studies have identified a subset of T-ALLs whose transcriptional programs resemble those of early T-cell progenitors (ETPs), myeloid precursors and hematopoietic stem cells. Importantly, these so-called ETP-ALLs are characterized by early treatment failure and an extremely poor prognosis. The unique ETP-ALL gene expression signature suggests that the epigenomic landscape in ETP-ALL is markedly different as compared to other genetic subtypes of human T-ALL.My project aims to identify genome-wide patterns of DNA methylation and histone modifications in genetic subtypes of human T-ALL as a basis for elucidating how DNA methylation drives the expression of critical oncogenes in the context of poor prognostic ETP-ALL. Given that these ETP-ALL patients completely fail current chemotherapy treatment, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Photon-based scalable quantum information science' (PHOQUS), addressing dissemination and exploitation.

assistant: **Impact**

A grand challenge of our age is to develop platforms for quantum information processing. The optical photon plays a key role: it allows quantum information to be transmitted over long distances and the encoded quantum information is robust, making photons attractive qubits for quantum computing. Resource states consisting of a small number of entangled photons constitute the fundamental building block that subsequently can be fused into larger entangled states by interference – a simple operation in photonics. These states can be tailored to be robust against errors and constitute a universal resource enabling full-scale quantum computing. We propose to create high-fidelity resource states with semiconductor quantum emitters for advanced quantum information processing applications realized on novel quantum hardware. Such an endeavor requires a very close collaboration between quantum materials science, semiconductor and device physics, quantum optics experiments, and quantum information theory/architecture development. We will develop low-noise quantum dots and fabricate waveguides and cavities to realize coherent spin-photon interfaces capable of generating highly indistinguishable multi-photon entangled states on demand. The operation wavelength will initially be in the near infrared and subsequently at the telecom wavelength. Using coherent spin control, we will generate seed entangled states with up to 10 photons, and photon fusion and dipole-coupled emitters will be employed to realize photonic quantum gates. Hereby advanced sources of multi-photon graph states with tailored entanglement topology can be obtained. Proof-of-principle demonstrations of device-independent quantum key distribution, quantum error correction, multimode quantum networks, and elementary qua