RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reconstitution of Crista Junction proteins using DNA origami-based Molecular Scaffolds for Structural and Functional analyses' (DNA-MolScaff) targeting Horizon Europe.

assistant: **Abstract**

Mitochondrial cristae are functional dynamic compartments containing the respiratory chain complexes where oxidative phosphorylation occurs. They are separated from the inner boundary membrane by highly curved and tightly regulated membrane compartments called crista junctions (CJs). A key multi-protein complex, mitochondrial contact site and cristae organizing system (MICOS), is enriched in CJs and plays a central role in modulating the architecture and function of CJs. Recently, a MICOS subcomplex built by the Mic60-Mic19 tetramer was proposed to traverse the CJ like a molecular strut and hypothesized to act as a diffusion barrier for metabolites and proteins between the inner mitochondrial membrane and the cristae lumen. However, the exact location of this MICOS subcomplex in CJs, its proposed diffusion barrier function and its detailed role in modulating CJ architecture are not clear. Here, I propose to fabricate a CJ mimic to reconstitute the Mic60-Mic19 tetramer into an octagonal donut-shaped DNA origami scaffold. The surface of the DNA origami will be coated with a lipid monolayer, enabling stabilization of the reconstituted complex, and facilitating structural studies using cryo-electron microscopy (cryo-EM). Subsequently, the role of Mic60-Mic19 complex and its intrinsically disordered regions as a diffusion barrier will be probed by incorporating the CJ mimics onto the surface of the liposomes. These efforts will reveal the structure of the Mic60-Mic19 subcomplex in a near-native environment and its role in the transport of proteins and metabolites, thereby providing an in-depth understanding of its cellular function. The realization of membrane-coated DNA origami molecular scaffolds as platforms for reconstituting proteins may pave the way for nano-tools that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Virus discovery and epidemic tracing from high throughput metagenomic sequencing' (VIROGENESIS).

assistant: **Concept**

NGS analysis pipelines are rapidly becoming part of the routine repertoire of research, clinical and public health laboratories in the public sector and private industry. Middle East Respiratory Syndrome-coronavirus (MERS-CoV) is only one example of the many recent virus discoveries made through analysis of next-generation sequencing (NGS) data. Yet, only a small part of the several millions of short-length sequence fragments generated by NGS machineries, many of which are expected to be of viral origin, can be analysed with current methods in bioinformatics. Even for well-known (pathogenic) viruses, proper epidemiological analyses are becoming more and more difficult due to the lack of bioinformatics tools that can handle the large and growing size of datasets.  The VIROGENESIS consortium will overcome the most pressing bioinformatics obstacles to making full use of NGS by developing a software platform for end-users with tools underpinned by novel algorithms, models and bioinformatics methods. The speed and flexibility of the tools will make it possible to run analyses on a daily basis for a variety of subjects, including diagnostics, phylogeography, phylodynamics and transmission of drug resistance. The tools will be piloted and incorporated in the many available bioinformatics pipelines and software programmes used in the field. We will make our tools available in a modular, free and open source software platform that offers opportunities to SME’s to further exploit this market. The VIROGENESIS consortium brings together leading European academic and private small and medium enterprises (SME) bioinformatics developers and virology end-users who initiated this project in response to a clear interest from EMBL, NCBI and the Global Microbial Identifier (GMI) platform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Machine Learning-aided Multiscale Modelling Framework for Polymer Membranes' in the context of a Horizon 2020 call.

assistant: **Objectives**

The goal of this project is to build a systematic modelling framework for advanced polymer materials, that are widely employed in numerous membrane separation applications, especially as gas separation media for carbon capture. Polymers are very challenging to simulate, due to the wide range of timescales that are present in these systems and require elaborate system-specific multiscale strategies. A hierarchical simulation strategy will be developed, encompassing atomistic, mesoscopic and continuum scales, integrating machine learning techniques. The artificial intelligence aided multi-scale approach proposed constitutes a generalized methodology for the efficient computational study of polymers. The synergy of unsupervised machine learning (ML) clustering techniques and neural networks (NN), will enable the extraction of accurate coarse-grained (CG) representations and force fields of the polymer systems, bringing this complex problem within computational reach. Optimized ML models will be integrated into Molecular Dynamics and innovative Monte Carlo simulations at the CG level, with the latter enabling the equilibration up to high molecular weight of polymers of complex chemical constitution, and the prediction of their micro- and macroscopic behaviour. Molecular simulation results will be integrated into macroscopic equation-of-state-based models, resulting in a bottom-up determination of the relevant process parameters for membrane separations (permeability and selectivity) in a wide range of conditions, for pure gases and gas mixtures. Systematic hierarchical modelling provides unique property prediction means, simultaneously shedding light on the mechanisms that are responsible for the materials end-use performance. This is a stepping stone towards the rational d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Socio-economic implications for individual responses to Air Pollution Policies in  EU +27' to be submitted under Seventh Framework.

assistant: **Abstract**

SEFIRA has the objective of creating a European coordination of transdisciplinary scientific and socio-economic resources in order to support the review and implementation of air quality legislation by the European Commission (EC) led by DG Environment. The EC has now given increased attention to the socio-economic dimension of air quality policies in order to improve their effectiveness and acceptability. SEFIRA will coordinate some of the best scientific and socio-economic resources and will review air quality policies and legislation at the interface between environmental, economic and social sciences in order to achieve a deeper understanding of these complex issues. Individual behaviours and choices will be analysed in a socio-economic context ranging from the local to the European level. The main fields involved in the action will be atmospheric sciences, environmental and legal sociology, anthropology, geography and economics.The integration of disciplines, the relationship with the most relevant stakeholders and an effective coordination between the SEFIRA consortium and other European projects in the same field will be a priority. The project strategy will support the development of a new European appraisal of problems and resources in the field, will deploy a pilot survey and a test of policy implementation by innovative models of individual choices analysis and ecosystem services valuation. Stakeholders will be involved from the beginning of the project in a process of dialogue and cooperative problem solving in order to ensure relevance and robustness as the work progresses from local to European level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'BUffet and Transition delay control investigated with European-Russian cooperation for improved FLIght performance' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

BUTERFLI is a project in response to the invitation to tender from European Commission FP7 within Call FP7-AAT-2013 RTD-Russia.BUTERFLI is the acronym of BUffet and Transition delay control investigated within Europe-Russia cooperation for improved FLIght performances. The Project Topic will focus on experimental and numerical flow control investigations of different phenomena: the buffet on a laminar airfoil, the buffet on a turbulent supercritical airfoil, and the cross-flow instabilities on a swept wing. Different control techniques will be studied: bump design, fluidic control devices, and DBD devices. The Project aims at the improvement of aircraft flight performances.This Project will be carried out in the framework of a EUROPE – RUSSIA cooperation. ONERA is the coordinator, and TSAGI will act as Coordinator of the Russian Partners.There are 12 partners, 7 from Europe and 5 from Russia.ONERA (F), IAG-Stuttgart (G), DLR (G), KTH (S), University of Nottingham (UK), EADS UK Ltd. (UK), TsAGI (Russia), MIPT (Russia), JIHT (Russia), ITAM (Russia), Sukhoi Civil Aircraft (Russia), and Erdyn (F).BUTERFLI is splitted into four work packages:WP1 is dedicated to buffet control on 2D turbulent supercritical wing (tangential jet blowing and plasma actuators)WP2 is dedicated to buffet control on 2D laminar wing (bump and perforation blowing)WP3 is dedicated to crossflow instabilities control on swept wingWP4 ensures the scientific coordination of the overall project, and will proposes final roadmaps for the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhanced co-operation between EU member states and associated candidate states in maritime research on transport' (2002-2006).

assistant: **Concept**

ENCOMAR-TRANSPORT aims to improve co-operation between the new member states, applicant countries as well as Russia, Ukraine and Turkey in the maritime fields. ENCOMAR-TRANSPORT has two general strategic objectives:- to support the integration of the new member states, applicant countries, Russia, Ukraine and Turkey into the European Maritime Research Area, thus supporting EU policies and the formation of ERA- to support the goals defined in the maritime part of the Sustainable Surface Priority of the 6 th Framework Programme. To support integration, ENCOMAR-TRANSPORT will help to jointly use R&D potentials and resources.ENCOMAR-TRANSPORT will promote a culture of innovation and fertilize participation of SMEs in European research. Technically, enhan ced exchange of information, technology transfer and research cooperation initiated by the project will help to meet demands of European transport policy and to the objectives of the sustainable surface transportpriority. Particular focus will be on:- S hipbuilding and -repair, including ship equipment manufacturers and maritime service providers,- Waterborne (long-haul, short sea and inland waters) transport in Europe.- Maritime Transport safety will especially focus on transport of dangerous goods to a void environmental- hazards in European waters, the Baltic and Mediterranean and Black Sea.- Efficient transport of marine natural resources is in the focus as well. The following activities will be undertaken:- Creation of a Network of Maritime R&D N ational Contact Points.- Inform about potentials and activities of European research in the new member states and neighbours of the EU by workshops in those countries. Inform research community and industry about the potential of countries not yet integra ted in European resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Automatic detection and monitoring of consciousness' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

When patients recover from coma, determining their level of consciousness can be difficult, even for an experienced clinician. Our goal is to provide a Consciousness Monitoring Index: a robust method to detect and quantitatively monitor the extent to which a human being is or is not conscious. Using electrodes attached to the scalp, we monitor the electro-encephalographic (EEG) signal which reflects ongoing brain activity. We have discovered and filed a patent for several mathematical indices which can be easily computed from the EEG, and which, alone or in combination, provide a continuous indicator of whether the person is or is not conscious. Our empirical studies in patients with coma, vegetative state show that our EEG-based markers can (1) accurately determine whether a patient is or not conscious at the time of testing; (2) establish how consciousness fluctuates from moment to moment; (3) predict, in a statistical manner, the capacity of the patient to recover consciousness.In this project, we propose to establish the scientific validity, technical feasibility, market potential, business model, and legal context for two distinct services that could be provided: (1) an off-line computer-based service for automated analysis of existing clinical EEG recordings, taking the form of a web server where clinicians would upload these data and receive a summary of indicators of consciousness. (2) an on-line bedside monitor of consciousness, taking the form of a tablet PC and dedicated EEG amplifier constantly displaying a scrolling view of indicators of consciousness, for real-time use by clinicians and by families, possibly with real-time feedback to patients.Our application is primarily intended for adult patients with disorders of consciousness, their doctors and their
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative Mechanically Pumped loop for ACtive Antennae' (IMPACTA).

assistant: **Innovation**

The satellite telecommunications industry is currently undergoing significant evolutions. Future commination satellites need to accommodate a rapidly growing demand in data transfer, combined with more flexibility. For example, there is a strong need for Very High Throughput Satellites capable of delivering up to Tb/s over wide coverage areas. This is only possible when an active phased array antenna is used. However, cooling of active antennas requires the use of a highly efficient thermal control system because it has many heat sources (from hundreds to several thousands), very high local heat fluxes (up to 200W/cm² at amplifier interface), high overall dissipation (around 13 kW), and an isothermal requirements on the amplifier chain. These conditions are impossible to solve with current state-of-the-art thermal control solutions (e.g. heat pipes or loop heat pipes), but requires a two-phase mechanically pumped fluid loop (MPL). In a MPL, a pump circulates a fluid which evaporates when it absorbs the waste heat from the active antenna. Although a two-phase MPL is a very efficient thermal control system, it is relative complex and is therefore not yet often used in spacecraft. This proposal aims to change that. The objective of this proposal is to perform research on a two-phase MPL for an active antenna, and to build a demonstrator with a Technical Readiness Level (TRL) of 6. This two-phase MPL will be a key building block in the next generation telecommunications satellitesThe consortium contains the complete spectrum of partners that are required to successfully research this disruptive novel technology. The consortium contains research institutes (CEA, NLR, CERN), SME’s (AVS, Diabatix) that can eventually commercially supply this technology, and an end-user of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Accelerated and standardised test procedures for testing the effects of chemicals on the performance of plastic packagings and intermediate bulk containers for the transport of dangerous goods' to be submitted under Fourth Framework.

assistant: **Abstract**

The objective of the project is to develop accelerated and standardized test procedures for testing the effects of chemicals on the performance of plastics packagings and Intermediate Bulk Containers (IBC's) for the transport of dangerous goods. This objective will be achieved firstly by the development of accelerated test procedures for packagings and IBC's produced from different plastics in such a way that with a selective number of standard chemicals and in a short time period the performance of packagings and IBC's can be evaluated. Secondly standardized European test methods for the assimilation of chemical substances to standard chemicals will be developed. The development of these test procedures is necessary in order to be able to progress with the implementation of new materials and packaging concepts and also to keep and improve the required safety level on the basis of European standardized test procedures. The results of the project will be implemented into the CEN-standards for packagings and IBC's for the transport of dangerous goods by the CEN-group TC261/SC1/WG6, which is part of the mandate M 086 of the European Commission. The participation of the leading European test institutes, the main manufacturers of plastics material and the manufacturers of packagings and IBC's in Europe gives the necessary platform for a successful execution of the project and the exploitation of its results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Commerce through mpeg4 on the internet with quality of services'.

assistant: **Concept**

Main ObjectiveThe main objective of COMIQS is the technical and service validation of a set of new paradigms introduced by recent and on-going innovations in ISO/MPEG-4/VRML (Virtual Reality Modelling Language) and the Internet IETF. Within the convergence process of interactive multimedia applications - ranging from entertainment to engineering - the COMIQS achievements will be validated in the field of Electronic Commerce.The added value and specific contribution of COMIQS reside in the implementation and experiment of the following service and technical features:  -All-media integration in a 3D virtual catalogue integrating digital high quality multimedia with video, photo-realistic images and high quality sound.  -Increased interactivity with content such as objects contained in motion pictures, audio tracks, 3D objects i.e. not restricted to clickable icons or buttons or hypertext links (already available on Internet).  -Real-time streaming of all media into the user-sided scene, facilitating navigation allowing at the same time a better adaptation of the content presentation process to available network resources.  -Placement of MPEG-4 into the Internet context, in the spirit of ITU-H.225 and of IETF Audio-Visual Transport Group.  -Quality of Service (QoS) management, from best-effort to predicted QoS, encompassing scaleable services on a variety of access networks, from narrowband to broadband Internet.COMIQS will focus on the exploitation of MPEG-4 added functionalities for the given applications.It will also address the use of DMIF for QoS provision in heterogeneous network environments. On the Internet side, COMIQS will work towards a Request For Comments (RFC) for MPEG-4 over Real Time Protocol (RTP).Technical ApproachCOMIQS will implement a European MPEG-4 p