RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Determination of two dimensional carrier/dopant profiling on the nanometer scale by the scanning capacitance microscopy' to be submitted under Sixth Framework.

assistant: **Abstract**

As the dimensions of semiconductor devices are increasingly reducing, two dimensional (2D) doping profiling techniques on the nano-meter scale is emerging as a very important issue for the semiconductor industry. As evidenced by the numerous discussions at recent conferences, scanning probe microscopy (SPM) based methods are among the most suitable because of their high spatial resolution. Scanning Capacitance Microscopy has the potential to become one of the most useful methods for measurements of doping/carrier concentrations. However, like all SPM techniques, SCM still does not fully meet the requirements of the International Technology Roadmap for Semiconductors (ITRS) in terms of spatial resolution, quantification accuracy, sensitivity and reproducibility. Hence further progress in this field is strongly required. The objective of this proposal is to continue a dedicated research activity on SCM taking advantage of previous training. A great variety of dedicated test structures will allow investigating optimal experimental conditions for SCM. Explorative manipulations on ultra-sharp tips will be performed to reduce tip wear and to obtain a sub-10 nm resolution as required by the ITRS targets. Alternatively, other techniques derived from SCM will be exploited to enhance the performance levels of this 2D-profiling tool. In the framework of national and European networks, strong interaction with research groups and industrial partners will be also developed. In particular, the networking will ensure comparisons between SCM and complementary SPM methods to bring them towards the required limits. Through this work, we expect to improve our scientific knowledge in order to reach a high degree of expertise in SCM. The improvement of the method is a real challenge and coul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Immune Synapse Engagement as a Novel Approach for Cancer Immunotherapy'.

assistant: **Innovation**

Monoclonal antibodies (mAbs) targeting immune checkpoints have revolutionized cancer treatment but exhibit several challenges, most notably, limited intratumor efficacy and relatively low patient response rates. Endowing these mAbs with immune-cell-recruitment capabilities may offer the solution to these drawbacks. This assumption is based on our recent findings that the effectivity of a given checkpoint mAb relies not only on its binding to its target T-cells receptor but also on the direct interaction of the targeted T-cell with dendritic cells (DCs). Our results suggest that the low-frequency or dysfunctionality of such stimulating immune synapses following checkpoint mAb treatments hinder their anti-tumor efficacy. Therefore, the outcome of not taking this T-cell-DC licensing loop mechanism into account in mAb design is suboptimal checkpoint mAbs. To overcome these limitations, we propose here to develop a series of bi- and muti-specific immune synapse engager antibodies as a new approach to enforce immune interactions for cancer immunotherapy. We will apply in-vivo genetic tools and high-dimensional analysis of the immune response on the spatial, cellular, proteomic and transcriptomic levels to provide critical insights into immune synapses that mediate effective T-cell anti-tumor activity. We will then harness this knowledge to apply antibody-engineering approaches and treatment regimens to maximize anti-tumor activity. We will explore and target T-cell-DC synapses that enable antagonistic (Aim 1) and agonistic (Aim 2) checkpoint mAbs and additional types of immune cell interactions underlying favourable immune surveillance of tumors (Aim 3). This study will introduce a novel approach for cancer immunotherapy using drugs that engage physical crosstalk between key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart Multidetector Submicrosensors' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This project is concerned with the technology of and the market for smart and intelligent submicro sensors where the term smart" implies the incorporation of the sensing device of programmable microprocessor controlled signal conditioning, signal processing and data communication circuitry. Smart multidetector submicrosensor (SMS) build with very small monochromator and submicro processor will be able to treat optical and chemical physical data. SMS has technical and economic advantages in many industrial applications particularly where re-calibration and re-ranging need to be carried out remote or where accuracy, reproductibility and reliability are at a premium."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Non-Western Migration Regimes in a Global Perspective' in the context of a Horizon Europe call.

assistant: **Objectives**

According to the latest World Migration Report, 12 of the 20 top destinations for international migrants in 2020 were countries not belonging to what are considered traditional (Western) migrant-receiving countries in North America, Western Europe, and Australia. Yet, despite these ever-growing migratory processes in non-Western migration locales, the mainstream literature remains largely focused on the study of migrants’ experiences and immigration policies in the context of traditional Western liberal democracies. As a result, major non-Western migration destinations elsewhere in the world remain underrepresented by existing theories and comparative research within migration studies. The overarching objective of the MARS is to increase our scientific understanding about global, regional and national governance of migration and mobilities and thereby to contribute to the global and national efforts to facilitate safe, regular and orderly migration. This aim will be accomplished by conducting research and a staff exchange programme on non-Western migration regimes. More specifically, MARS is constructed around three interlinked goals, which are to 1) collect original empirical data on the interplay between migration governance processes and migrants’ experiences in non-Western migration locales; 2) engage with and situate our research in relevant theoretical and comparative debates within migration studies and thereby advance scholarly discussion on contemporary migration regimes (comparative migration studies) by developing new conceptual and methodological approaches to understanding migratory processes in non-Western locales; and 3) translate research findings into policy-relevant ways, including presentations and policy papers to provide strategic intelligence and p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Unified Modeling and Automated Scheduling for Manufacturing as a Service'.

assistant: **Concept**

Manufacturing in Europe should urgently address the following challenges towards the adoption of the Manufacturing as a Service paradigm: product customisation, circularity and sustainability, minimal downtime, predictive maintenance, seamless communication, reliability and robustness to uncertainties in demand and variability of resources, and cost reduction and performance optimisation. Unified Modeling and Automated Scheduling for Manufacturing as a Service (UniMaaS) project will develop a platform with a set of advanced technologies for offering flexible and decentralized manufacturing resources and supply chains as a Service to European SMEs and Industries. To realize this vision, the proposed platform will deploy 3 integrated Suites: (i) Data Modelling Suite: offering manufacturing dataspaces, cloud-based resource monitoring, trusted cross-company data exchange and digital product passport, (ii) Modelling Suite: offering modular modeling of manufacturing resources, intent-based servitization , AI-based estimations and Zero-X analysis, and (iii) Decision-Making Suite: offering scheduling and planning of manufacturing resources, circularity and sustainability optimization. The platform will adopt advanced digital technologies such as cloud computing, digital twins and trustworthy AI, as key enablers towards fulfilling its objectives. UniMaaS platform will provide easy access to customized manufacturing service chain and will support the entire life-cycle management of processes and products.  The UniMaaS Suites and the Platform will be demonstrated in 4 Pilots including aircraft maintenance, automotive seating, 3D construction printing and logistics/warehouse management.


**Keywords:** Manufacturing Data Spaces, Digital Product Passport, Hybrid Systems, Control The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Systems Biology approach to disclose auxin synthesis in plants' (SYSBIOAUX) under Seventh Framework.

assistant: **Objectives**

Because plants have a sessile lifestyle, they must adjust to various external cues and coordinate their developmental program accordingly. To facilitate survival in often hostile environments, plants have evolved a notable developmental plasticity that allows them to shape their body and optimise their metabolism according to specific environmental demands. As with other multicellular organisms, the coordination of plant development relies on the communication across cellular boarders. In this context, plants employ a chemical-based network to control their developmental and physiological processes. Central to this network are a limited number of small molecules, called phytohormones. They are responsible for the adequate transcriptional reprogramming of tissues answering to external cues or for the maintenance of coordinated development. Although several molecules are known to function as plant hormones, plant shape is largely controlled by auxin. Over the past decades the knowledge of auxin action and signalling has greatly improved. By contrast, the synthesis of auxin is still not fully defined with respect to catalysed reactions and enzymes involved. Currently, it is assumed that a small number of alternative biosynthetic pathways contribute to auxin biosynthesis in plants. Due to prevailing knowledge gaps, extensive functional redundancy, and tissue and plant specific variations in expression patterns of the identified components, the relevance of each of these pathways is difficult to assess. The main focus of this project is to close the existing knowledge gaps and to decipher the pathways of auxin formation in plants. In addition, the cross-talk between the individual pathways and their regulation will be studied. To achieve these goals, a truly Systems Biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Function and dysfunction of blood vessels: transcytosis in normal/pathological states, alterations in atherosclerosis and diabetes; their therapeutic control', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Our Institute occupies 5 floors (4000 sq.m) has a staff of 100 of which 36permanent researchers, 14 assistants; there are 10 PhD students. Funds provided from national and foreign Grants. Many researchers were trained abroad. The research focuses on the bio pathology and cell pharmacology of the cardiovascular system. Publications: papers in peer-review journals, 50 chapters in internationals monographs. Elected member institution of UNESCO-MCBN, and Centre of excellence of the Romanian Academy .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploiting the synergies between Gaia and spectroscopic stellar surveys to constrain next-generation Milky-Way models' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Galaxies are complex systems governed by competing physical processes that happen on very different space, time and energy scales, such as mergers, internal secular evolution, gas flows, star formation, supernova feedback, gas cooling etc. The field of Galactic archaeology aims at disentangling these processes, eventually unfolding the detailed formation history of the our Galaxy. Major observational campaigns, such as the astrometric Gaia mission, the asteroseismology missions CoRoT and Kepler, as well as large-scale ground-based spectroscopic surveys, are dedicated to gather kinematic, chemical, and age information for millions of stars. The wealth of new data has recently put the goal of reconstructing the Milky Way's formation history within closer reach. While the Galactic astronomy community is convinced that combining as many observational constraints for as many stars as possible will be the way forward in the field, it is clear that the complexity and richness of the new data is also a major challenge to our state-of-the-art analysis methods. At this moment, the field is in urgent need of more sophisticated comparisons to current models, and clear indications where these models should be improved. However, there is still a lack of publically available software that facilitates complex model-data comparisons for the theoretical as well as for the observational community. We will undertake a major analysis project exploiting the synergies between Gaia and complementary spectroscopic survey data to constrain Galactic models, and to simultaneously provide the community with legacy tools and datasets that will greatly facilitate such studies in the future. The project will produce value-added catalogues with precise astro-spectro-photometric ages, distances and exti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Stone monument ensambles and the climate change impact'.

assistant: **Concept**

Given the fast pace of climate change there is an urgent need to address the threats it poses on cultural heritage (CH) by a holistic framework that will engage scientists, conservators, citizens, creative industries and decision-makers to develop and act on new, sustainable strategies of long-term preservation of CH, as proposed by this project. For the first time, the future of stećci - a tangible phenomenon included on the UNESCO World Heritage list, and similar limestone monuments will be assessed under 2 high resolution climate scenarios in three periods: 2021-2040, 2041-2060 and 2081-2100. In situ condition assessment supported by comprehensive scientific analyses will be followed by remedial conservation on selected sites to develop best practice and to produce efficient monitoring and conservation guidelines coupled to economic analyses and climate scenarios. Such an output will accentuate the need of timely and appropriate interventions and facilitate the decision-making process of authorities. Digitization methodologies will be also explored. Basic and high-end techniques will be mutually compared in order to simplify and amplify the digital recording of cultural heritage in Europe. Further on, the project aims to turn the potential of necropoles into new opportunities and resources for socio-economic and creative entrepreneurship developments of local communities. Work on valorization of cultural heritage and social labs with a series on events on citizen science, story telling and place-making activities will precede the development of sustainable cultural tourism strategies that can be implemented across Europe. Art, tools of creative industries and cultural values will thus be used as powerful engines of regeneration, economic growth and sustainable protec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Surface Physics for Advanced Manufacturing' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Today, markets demand smaller, cheaper, energy friendly and more different consumer products. Last decades micro technology has opened possibilities for mobile communication, safety and health science products. To meet these demands, the industry is encountering technological barriers that prevent the industry from evolving from the micro to a nanotechnology era.  To resolve these barriers, the industry and research institutes need to initiate research programmes, and need to structure and integrate its research programmes and transfer the knowledge that as been acquired in these programmes. “New” researchers have to be trained with excellent research skills, knowledge on the specific technology, and understanding of market demands, application development, and so on. For this purpose 4 industrial, 5 academic and 3 research institutes have defined the 4 year SPAM research and training program; “a Supra-disciplinary approach to research and training in surface Physics for Advanced Manufacturing - SPAM”.  Research objectives are: • identify and develop crucial knowledge in the field of surface physics, • enable the manufacturing of smaller semi-conductors and hence technology to print under 32 nm; extreme positional accuracy (< 4 nm); at competitive cost, • use this knowledge to further develop lithography technologies/tools needed for cost efficient development of nano-electronic devices, including manufacturing processes.  Training objectives are: • provide personalised individual training, in particular for 16 ESR but also for 6 ER, to prepare and optimise their research in SRTs, with the help of 9 VS. • provide a network-wide training, fully exploiting the network potential and complementarities, leading to 12 network events. • transfer existing knowledge between part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Human ModeL MATROSHKA for Radiation Exposure Determination of Astronauts'.

assistant: **Innovation**

The European Space Agency’s project MATROSHKA (MTR), dedicated to determine the radiation load on astronauts in- and outside the International Space Station (ISS), launched in Jan. 2004 and is currently in its experimental phase 3. MTR is an anthropomorphic upper torso phantom containing over 6,000 radiation detectors to determine the depth- and organ dose distribution in the body. It is the largest international research initiative performed in the field of space dosimetry, combining the expertise of leading research institutions all over the world. Consequently it generates a huge pool of data of immense value. Aiming at optimal scientific exploitation, the project HAMLET will bring together a European expert committee, consisting exclusively of members of the MTR consortium, to process and compile the data acquired individually. Based on experimental input as well as on radiation transport calculations, a three-dimensional model for the dose distribution in an astronaut’s body will be built up. The results describe the exposure conditions both for extra-vehicular activities (MTR-1:2004–05) and inside the ISS (MTR-2A/B:2006–08). The project goes beyond essential data analysis and incorporates a modelling approach to guide new experimental measurements and strengthen the predictive capacity. This allows further utilization of the data, particularly with respect to detailed modelling of radiation interactions in the human body. The scientific achievements contribute essentially to radiation risk estimations for future interplanetary human missions, putting them on a solid experimental and theoretical basis. The synthesis of data, considerably extending previous knowledge, constitutes a major accomplishment by which Europe can establish worldwide leadership in this speci