RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High Throughput Synthesis of Polymeric Vesicles for Protein Delivery' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The delivery of therapeutic protein drugs in biological environments is hampered by their relative sensitivity to a broad range of physical and chemical factors. To address this loss in therapeutic efficacy, chemical formulations using polymers as stabilising agents have been proposed. Unfortunately, systematic studies of these formulations are often limited in scope owing to the relatively high cost of protein therapeutics as well as restrictions on the types of chemical transformations that can be performed without loss of protein activity. Hosted within Prof. Molly Stevens' labs at Imperial College London (www.stevensgroup.org, recognised by >25 major awards), the overall goal of this proposal is therefore to develop a versatile chemical synthetic platform enabling the efficient synthesis of protein encapsulated polymeric vesicles. This will be achieved by exploiting low volume, high throughput polymer chemistry to allow for a cost and time efficient study of vesicle structure-activity relationships in the context of protein stabilisation and efficacious delivery of proteins to biological targets. The proposed combinatorial approach is highly versatile and can, in principle, be applied for the study of a broad range of proteins or other biologically relevant therapeutics. The versatility and translation potential of this project will be fully evaluated within the excellent infrastructure available within the Stevens Group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel Regulatory Principles of Polycomb Repressive Complex 2' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Posttranslational modifications of histone proteins have emerged as central regulators of gene expression. Through the factors that install, interpret, and erase them, histone marks control access to the genome, establishing chromatin environments that either support or counteract transcription. The histone methyltransferase Polycomb repressive complex 2 (PRC2) is crucially involved in gene repression all throughout development and adulthood, and it is often misregulated in cancer. Despite significant advances in the field, key aspects of PRC2 function remain largely elusive. The overarching goal of this project is to enhance our understanding of how PRC2 is regulated and how it controls the expression of developmental genes in embryonic stem cells. To this end, my research team and I will analyse how PRC2 cooperates  with other histone modifiers and chromatin organisers at enhancers to achieve poising of developmental genes (Aim 1). These studies will enable us to appreciate how the pivotal PRC2 module interfaces with other players in the complex chromatin regulatory system, contributing to a much-needed integrated view of chromatin regulation. We will further unravel how generation of the recently discovered asymmetric nucleosomes, in which the two copies of histone H3 are disparately modified (Voigt et al., Cell, 2012), is controlled by PRC2-intrinsic catalytic properties and through interactions with other chromatin modifiers (Aim 2). This will ultimately allow modulating asymmetry in vivo, providing unprecedented means to assess its impact on PRC2 function and chromatin structure. Lastly, I aim to re-evaluate the issue of PRC2 recruitment to its target loci by employing a systems biology-informed quantitative approach (Aim 3). Together, the aims of this ambitious p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Light driven hybrid nanocrystal TMDC capacitors' (Light-DYNAMO) under Horizon 2020.

assistant: **Objectives**

Sunlight is an intermittent energy source coupled to the availability of the sun. Light-DYNAMO aims for an innovative solution to directly store the solar energy. The challenge is to implement solution-processable light-driven nanocrystal capacitors (NCCs), such as doped metal oxides. They show high charge-storage capacity accumulating multiple delocalized electrons after light absorption. This was to date shown in solution only with the additional drawback of reducing the hole with a sacrificial hole scavenger. The innovative aspect of Light-DYNAMO is to use 2D transition metal dichalcogenides (2D TMDCs), such as MoS2 or WS2, as efficient hole acceptors in a solid state structure. The sensitivity of the TMDCs’ spatial electronic landscape to the local environment (i.e. strain, defects or doping) serves as driving force for energetically driven hole relocation within the TMDC. The electrons instead remain in the NCCs. This results in long-lasting and efficient charge separation and opens novel design principles. In optimized device structures, such stored carriers are extracted. The working principle of the suggested NC/TMDC hybrid device is based on several challenges: first, the absorption and charge storage capacity of the NCCs will be enhanced by exploring novel materials. Second, the TMDC’s sensitivity to the surrounding will be extracted to a high level of control over the 2D energy level distribution. Third, the intentional design of the energy landscape (e.g. through strain manipulation) in the optimized hybrid geometry will be introduced to control carrier redistribution after charge transfer within the TMDC. Finally, appropriate devices for carrier extraction will be structured. The proposal embarks on a pioneering study by the PI on optical control over carri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MegaModelling at Runtime - scalable model-based framework for continuous development and runtime validation of complex systems.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

European industry faces stiff competition on the global arena. Electronic Components and Systems become more and morecomplex, thus calling for modern engineering practices to be applied in order to better tackle both productivity and quality.Model-based technologies promise significant productivity gains, which have already been proven in several studies andapplications. However, these technologies still need more enhancements to scale up for real-life industrial projects and toprovide more benefits in different contexts.The ultimate objective of improving productivity, while reducing costs and ensuring quality in development, integration andmaintenance, can be achieved by using techniques integrating seamlessly design time and runtime aspects. Industrial scalesystem models, which are usually multi-disciplinary, multi-teams and serving to several product lines have to be be exploitedat runtime, e.g. by advanced tracing and monitoring, thus boosting the overall quality of the final system and providinglessons-learnt for future product generations. MegaM@Rt brings model-based engineering to the next level in order to helpEuropean industry reducing development and maintenance costs while reinforcing both productivity and quality.To achieve that, MegaM@Rt will create a framework incorporating methods and tools for continuous development andruntime validation to significantly improve productivity, quality and predictability of large and complex industrial systems.MegaM@Rt addresses the scalability challenges with advanced megamodelling and traceability approaches, while runtimeaspects will be tackled via so-called “models@runtime”, online testing and execution traces analysis.MegaM@Rt brings together a strong international consortium involving experts from France, Spain, Ita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A secure wearable for payments, ticketing, access control and ID management' to be submitted under Horizon 2020.

assistant: **Abstract**

Keys, credit cards & transport tickets are becoming fully digital—they are increasingly getting replaced by smartphone apps. This shift is fuelled by the ubiquity & convenience of smartphones as well as increasing support for short distance communication protocols (such as NFC or BLE) by different hardware. This increasing digitalization of everyday life requires secure authentication, which passwords, cards & keys frequently cannot meet as they are prone to losses & attacks. There is a market opportunity for a novel biometric solution that overcomes the deficiencies of the existing solutions and makes end-user transactions smooth & secure. While device OEMs like Apple or Samsung are using fingerprints & face recognition as core biometrics, we have designed a completely novel approach to ultra-secure biometrics authentication and built a device around it.BiowatchID is a smart band worn on the wrist, which is a secure vault that only the owner can use due to continuous biometric authentication. BiowatchID uses a secure patented wrist vein identification technology with demonstrated 99,999% reliability. It is a tamper-proof, military grade security device which supports multiple protocols & communication channels.Once BiowatchID is closed on the wrist, it scans & recognizes the unique vein pattern, and then continuously monitors the presence of the wrist.BiowatchID is designed to replace ID cards & passports; credit cards, loyalty cards, mobility cards; car keys, passwords, access badges; (and in the long term) Touch ID, Face ID & other similar biometric authentication solutions. Most importantly, BiowatchID can combine all of the above in a single wearableOur research shows that there will be at least 160m wearable devices with seamless biometric authentication solutions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SERVICE PROVISION OF GEOSPATIAL INTELLIGENCE IN EU EXTERNAL ACTIONS SUPPORT' (G-SEXTANT).

assistant: **Concept**

The goal of G-SEXTANT is to consolidate a portfolio of Earth Observation products and services that support the geospatial information (geoinformation) needs of the European External Action Service.The exploration of the Security dimension of GMES, the definition of services and products to respond to the user’s demands, and the implementation of an appropriate governance will be consolidated in G-SEXTANT from the lessons learned from previous projects.Focusing on the gaps identified in previous security projects, the major objectives of the G-SEXTANT are: 1) preparation and delivery of pre-operational services in user-driven SEA scenarios; 2) further enhancement of already mature products and services demanded by the users; and 3) to reach a standardised portfolio.Demonstrations will be conducted in different scenarios to cover the potential application areas of interest identified by the SEA working group and mentioned in the Call: humanitarian crisis, natural resources, land conflict situation awareness, nuclear activities, monitoring of illicit crops and border monitoring outside the EU.The G-SEXTANT project is organised to exploit the experience and skills of the different stakeholders involved: industry (production and implementation capacity), institutional organizations (experience in R&D activities) and EU organizations (consistency with EU policy and operations and access to intelligence data).Involvement of users in validation activities will ensure the achievement of appropriate products and services and provide the exact measurement of the impact of G-SEXTANT in the security user community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural and functional determinants of GRK2 in cardiac development' to be submitted under Sixth Framework.

assistant: **Abstract**

G protein-coupled receptor kinases (GRK) provide the rate-limiting step for terminating incoming signals at G protein-coupled receptors (GPCR) to protect the cell from over-stimulation. GRK2, the most commonly expressed GRK, has been shown to regulate hear t function in the adult and during development as GRK2 knockout (KO) mice die during embryonic development. Since the reason for the embryonic lethality has been analysed only preliminary, I want to uncover the molecular mechanism to provide a biochemical explanation for the action of GRK2 in ensuring normal cardiac development and in the course of cardiovascular diseases.The aims of the project are:1) Generation of a GRK2 knockdown in zebra fish and its histological and biochemical characterization.2) De termination of the GRK2 structures relevant for the assessed phenotype.3) Investigation of affected signalling cascades.4) Transfer of the zebrafish results back to mice.The novelty of the project is based on a combined in vivo approach to explain the bio chemical function of a protein of highest relevance in man by using a second model organism instead of extrapolating in vivo relevance from in vitro or cell culture studies. To accomplish this, I will be trained in manipulating and analysing zebra fish and in techniques commonly used in signal transduction such as site-directed cloning and biochemical assays, which will complement my previous research experience in mice and chicken embryos. In addition, I will not only widen my international experience in research, but also my personal horizon.Therefore, the Marie Curie Out-going International Fellowship will serve my professional growth by enabling me to gain knowledge in the investigation of signal transduction and the handling of a third model organism, giving me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Selective Conversion of Water and CO2 Using Interfacial Electrochemical Engineering' in the context of a Horizon 2020 call.

assistant: **Objectives**

The recycling of CO2 will play an important role in mitigating the energy and environmental problems that our future societies will no doubt face.  Electrochemistry is a powerful technology that can make use of renewable electricity from solar and wind to power the transformation of CO2 and water to valuable chemicals and fuels.  However, the electrochemical conversion of CO2 is not ready for large-scale deployment due to the poor activity, selectivity, and stability of the current catalysts used. The only way to be able to achieve better understanding of this complicated system is through careful characterization of the catalyst/electrolyte interface during electrochemical measurements, as well as the development of new theoretical models that include the effects of the electrolyte. In this proposal, I will develop an integrated approach to study the effects of the catalyst and electrolyte compositions on the formation of desired chemical products during electrochemical CO2 reduction. To ensure a robust model of the catalyst/electrolyte interface can be established, I will focus on manipulating the catalyst and electrolyte compositions in parallel, while observing the formation of reaction intermediates as a function of applied potential. The proposal will focus on Cu-based electrodes, as Cu has uniquely shown the ability to form hydrocarbon products.  To understand how the product formation changes, operando techniques will be used to monitor the reaction intermediates during electrochemical cycling, to reveal new insights to the reaction pathway for a given product.  A theoretical model will be developed in parallel that focuses on understanding the nature of the electrochemical activity of ions used in this reaction.  Finally, the transport and reactivity of these i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Development and implementation of a generic marine sar analyses and interpretation system for application to the coastal zones (MARSAIS)'.

assistant: **Innovation**

The availability of SAR data has for nearly a decade provided regular and global observation of ocean wave spectra. Furthermore, its capabilities to detect and locate oil spills, bathymetric features in shallow water, and ships have also lead to systematic use of SAR images in operational surveillance associated with marine coastal pollution control, bottom mapping, and fisheries. Recently, a new emerging application has been developed for the monitoring of atmospheric boundary layer processes and mesoscale coastal wind fields. Additional application of the SAR data for upper ocean current and feature monitoring, implies that the SAR can play a vital role in coastal ocean observing systems. This is the philosophy behind the MARSAIS proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Reasoning About Computational Economies'.

assistant: **Objectives**

The aim of this project is to develop, apply, and evaluate RACE: a robust and practical model checking tool for use in the formal specification, verification, and analysis of computational economies – computer systems in which system components are assumed to have their own goals/preferences about the overall behaviour of the system, and where these system components are assumed to behave selfishly and strategically in the furtherance of their goals/preferences. The key deliverables of the project will of course include the RACE system itself, and in addition: new formalisms for representing and reasoning about computational economies, suitable for use in the RACE system and elsewhere; theoretical results (e.g., complexity analyses, axiom systems, . . . ) relating to the use of these formalisms; new algorithms and data structures for the verification and analysis of computational economies; and a library of case studies, demonstrating the use of RACE in a variety of settings. The project is both timely and essential. It is timely because computer networks populated by multiple self-interested computational entities are increasingly the reality of computing in the 21st century, and as a consequence, research in this area has witnessed a huge explosion of interest recently. It is essential because current formalisms, tools, and techniques for the specification, analysis, and verification of systems were not intended for, and are not appropriate for, this emerging reality. The project will build on two decades of enormously influential research by the PI, who is among the most highly cited researchers in computer science and artificial intelligence today.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Measurements to assess sunscreen efficacy in industrial research' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Sunscreens, made in Europe are a very important product on the international market. Quantitative data, and an exact knowledge of the protective efficacy covering the complete range of potentially harmful UV-effects, including erythema, UV-induced immune suppression and DNA damage, are an important prerequisite to improve the competitive position of the European Cosmetic Industry. This aim shall reached in the proposed project developing and testing a new in vivo measurement method to assess the efficacy of sunscreens in the UVB and UVA range in an non-invasive manner, and to correlate the measured spectral data with UV induced biological responses. As one result of the project work a higher security will be obtained determining the protective properties of sunscreens in the relation between solar radiation and skin cancer. The industrial partners will guarantee that the work is nearly connected with the needs of the industry. The expected results shall taken as a proposal for pre-standards in connection with COLIPA and CEN. The proposed project combines the method of tape stripping with UV/VIS spectroscopic measurements. By this way it is possible to determine the thickness of the horny layer as the prerequisite to measure the penetration depth of filter substances as well as the spectral UV intensity distribution inside stratum corneum. The obtained results will be reviewed by different modern analytical methods usually applied in industrial research assessing the efficacy of sunscreens and the behaviour of UV filter. The necessary relation of the measured intensities to the biological responses is ensured investigating the UV induced DNA damage and the immune suppression. This guarantees that the determination of the efficacy of sunscreens includes not only the forma