RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Visualizing trans-splicing molecular machines across scales' (TRANSPLIC), addressing dissemination and exploitation.

assistant: **Impact**

Trans-splicing is an essential mRNA processing step for a significant portion of living organisms. In trans-splicing, exons from two pre-mRNA precursors merge into a single mRNA, while cis-splicing rearranges exons within the mRNA. Despite recent technical advancements in cryo-electron microscopy (cryo-EM) that movie-like resolved different stages of cis-splicing, the trans-splicing mechanism is still a black box: input and output are defined, but the single steps of how the trans-spliceosome assembles and remodels to initiate the splicing cycle lie in the dark. This limitation is partially due to the absence of molecular structures resolving trans-splicing complexes. In TRANSPLIC, I will pioneer the assembly of trans-splicing complexes on pre-mRNA scaffolds to reveal the particular states unique to trans-spliceosomes. I will determine the molecular structures of trans-spliceosomes and uncover their behavior in the cellular context. Targeted functional assays will disclose the order of events leading to trans-splicing. The protist Trypanosoma brucei (Tb) will serve as an accessible model organism because it uses trans-splicing as an obligatory and abundant mRNA processing step. I will apply an ambitious approach that integrates in vitro and cell lysate-based methods, state-of-the-art cryo-EM, cryo-electron tomography, proteomics, and artificial intelligence-based computational modeling. I will complement the study through targeted functional experiments, leading to a complete understanding of the spatial-temporal resolution of trans-splicing in trypanosomes, with wider relevance to other organisms, including humans. The targeted fusion of gene sequences through trans-splicing bears potential as a molecular tool for transcriptome editing in the future.


**Keywords:** RN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Use of eco-friendly materials for a new concept of Asphalt Pavements for a Sustainable Environment'.

assistant: **Innovation**

Main objective of the project is the demonstration and validation of an eco-innovative design of asphalt pavements based on the integration of more sustainable materials into its production cycle. This goal will be achieved by working on two asphalt mixtures’ main components, binders and aggregates. On the binder side, the aim is to replace almost the 100% of the bitumen by greener materials from renewable raw sources, e.g. vegetable oils, by-products of bioethanol production. On the aggregates’ side, efforts will be made on the valorization of Construction and Demolition Waste and in the use of reclaimed asphalt for asphalt mixtures.Abstract: Road transport is the most important mode of surface transport in Europe- the EU-27 disposes of 5.000.000 km of paved roads- and it is fundamental to its social and economic development. The asphalt industry is one of the largest consumers of energy and raw materials, and highest contributor to the emission of greenhouses gases. Developing novel technologies to integrate waste and recycled materials into the production cycle of asphalt mixtures is a solution that improves both sustainability and cost-efficiency of the asphalt pavement industry reducing the CO2 footprint of these pavements and the environmental impact and associated costs related to the waste generation and disposal.  In this context, a new concept of eco-asphalt is presented combining greener binders, recycling aggregates from C&DW and reclaimed asphalt within an integrated solution for asphalt pavements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Large-scale piloting and market maturation of a novel process for sustainable European lobster aqua- and mariculture' (SELAM) under Horizon 2020.

assistant: **Objectives**

The objective of SELAM is to commercialise and bring to market our exclusive and high-quality EU lobsters based on our disruptive and fully automated production process for lobster aqua and mariculture. The fully automated SELAM process is combining land-based aquaculture of hatched eggs through the larval (1-3) and juvenile (4-5) stages before released into sea-ranching ocean mariculture, where growth happens without human interference and at no cost. Combined with our novel business model for shellfish sea ranching this will allow us to bring a new product to the market – sustainable and high-quality farmed EU lobster with significant added value for the customer compared to existing wild-caught alternatives.The SELAM concept was developed during our Phase I-type Feasibility Study - the FP7 NEPHROPS project, GA286903 - where the outcome was a novel production process with optimal production parameters (feed, light, temperature & water quality) at TRL7. Now we seek to op develop our Commercialisation Plan and final Business Innovation Plan (BIP). We have assembled a highly competent team holding all required resources, skills, facilities and networks to advance SELAM into a successful commercial product.To successfully introduce SELAM to the market, we have created 5 sequential and quantifiable Commercialisation Objectives focusing on overcoming remaining barriers hampering successful commercialisation:1. Technology maturation, elevating our SELAM process from TRL7 to TRL8 (WP1)2. Large scale piloting bringing SELAM to TRL9 (WP2)3. Supply chain development, up- and downstream (WP3)4. Product exploitation strategy development, market research and post-project funding (WP4)5. Innovation management and BIP development, IP management and stakeholder engagement (WP5)SELAM w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An Ecological History of Eurasian Art:  Natural Resources, Aesthetic Practices, and Early Modern Globalization' under Horizon Europe.

assistant: **Concept**

Works of art are repositories of environmental knowledge. Paintings, sculptures, and artifacts preserve material evidence of the use of natural resources like mineral pigments, plant-based dyes, and precious metals, and contribute to a visual archive of human interaction with nature by providing pictorial records of mining and deforestation. ECOART aims to rewrite art history as a history of ecological interconnections and prove that aesthetic practices were conditioned by environmental circumstances by examining the artistic use and visual representation of geographical, geological, botanical, zoological, and climatic resources across Eurasia, a space dominated by European and Chinese economic spheres of influence, in an era of early modern globalization from 1500 to 1800. The project investigates six key artistic sites with a focus on the Global South, an area still affected by the colonial exploitation of resources – the Indian region of Gujarat and the port cities of Manila in the Philippines, Jakarta in Indonesia, Guangzhou in China, Yangon in Myanmar, and Amsterdam in the Netherlands – with three objectives: 1. to analyze works of art as early modern repositories of environmental knowledge; 2. to reconstruct local ecologies of art and artisanship in the Global South in relation to trade and colonial exploitation; and 3. to make visible transcultural models of sustainability and creative reuse across early modern Eurasia. Digital mapping will demonstrate linkages between sites of artistic activity, resource extraction, and trade via overland and maritime connections. Through a geographic focus on under-researched regions of the Global South, and its transcultural and comparative methodology, ECOART will contribute to the decolonization of art history, provide theor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'She Sense: an accurate and non-invasive test that enables simpler, earlier and more cost-effective diagnosis of patients with endometriosis' (Endosolve) under Horizon Europe.

assistant: **Objectives**

Endometriosis is a chronic inflammatory disease defined as the presence of endometrium-like tissue outside the uterus. Establishment and growth of such endometriotic tissue is estrogen-dependent, thus it is mostly found in women of reproductive age. It is estimated that currently at least 190 million women and adolescent girls worldwide are affected by the disease during reproductive age although some women may suffer beyond menopauseShe Sense is an accurate and non-invasive test that enables simpler, earlier and more cost-effective diagnosis of patients with endometriosisProject scope: Experimental proof of principle for the novel digital biomarker has been demonstrated using early generation prototypes for research purposes in a pre-clinical model and exploratory human volunteer study. Sision Medical seeks to mature this technology and validate it’s use as a clinically acceptable diagnostic test. Therefore, the scope of this project will focus on the advancement of the She Sense test to investor readiness by;•Further refinement of the signal processing to optimise the digital biomarker performance•Validation of the biomarker in a clinical setting•Development of a sustainable business case and business model towards commercialisationThe end point of the project is the compilation and evaluation of data obtained in a prospective clinical study. EIC funding will enable Sision Medical to enhance the technology efficacy and validation in a clinical setting. This will pave the path for larger studies which will demonstrate clinically acceptable sensitivity and specificity of the She Sense diagnostic test.


**Keywords:** Endometriosis, diagnostic, digital biomarker
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Testing the Chinese Development Model under the Capabilities Approach: The Effects of Preferential Policies and Special Economic Zones on Inequality and Social Justice'.

assistant: **Innovation**

The People's Republic of China (PRC) gradually transitions from an export-led and investment-driven economy towards a service-led and consumption-driven economy. These upcoming reforms will affect firms that rely on Chinese goods and services, but also create new opportunities to sell goods and services to the emerging Chinese consumer market. Given the use of experimental and preferential policy treatments by the PRC over the last four decades to promote economic development, different sectors of the Chinese population and economy will have different capabilities and (dis)-advantages in the forthcoming transitions. This project will identify which population groups are heading towards prosperity and which are at greatest risk of remaining in poverty and development traps. While previous research have identified links between preferential policies and inequality, this research extends the existing studies by applying the Capabilities Approach, examining rights and social justice, which will help create a more prosperous consumer market. The varying levels of inequality, human capital, rights and social justice for the Chinese consumer market will be analyzed through club convergence and partial (meta) rankings methodologies from 1985 onwards. A development-capabilities index for different sectors of the Chinese population and economy will be developed to indicate policy makers, domestic and foreign firms, the public, and academics what the current state and potentials for the next market reforms will be. The results will be enable European, and international, firms to better target Chinese consumers and industries, and help academics develop a theoretical framework based on the Chinese preferential and experimental development experience.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Simulation-based design and development of a novel 3D printed ankle-foot orthosis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The research action involves an experienced researcher, Dr Xijin Hua, previously working at ETH Zurich in Switzerland and now working in the Institute for Manufacturing (IfM), Department of Engineering at University of Cambridge in the UK, to work on the project “Simulation-based design and development of a novel 3D printed ankle-foot orthosis (SPRINTAFO)” for 24 months under the supervision of Dr Sebastian Pattinson. The project aims to develop a simulation-based platform for the personalised design and development of 3D printed orthoses, and apply the platform to the design and optimization of a novel 3D printed ankle-foot orthosis (AFO). The action also aims to provide a platform for the fellow to acquire new knowledge and skills, and for the fellow and the host organization to share and transfer knowledge and skills in the fields of Musculoskeletal computational simulation, Biomechanics, Optimization, 3D printing, Material Sciences and Medical Devices. The outcome of the project will provide a leap forward in the development and manufacturing of cost-effective, highly personalised and functional tailored orthoses, through the integration of personalised biomechanical simulation model and 3D printing technologies, which will further strengthen the host organization’s leading position and competence as a multidisciplinary research unit in 3D printed medical devices. Moreover, the project will aim to develop long-term research collaborations between University of Cambridge and ETH Zurich, as well as between Europe and China by taking advantages of existing academic networks and industrial partnerships.


**Keywords:** Musculoskeletal simulation, Biomechanics, 3D printing, Medical devices, Orthoses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Study of immunogenicity of DNA HIV-1 env, gag and pol plasmid vaccines boosted with MVA in Tanzania; HIV vaccine immunogenicity study' under Fifth Framework.

assistant: **Concept**

HIV-l vaccines are urgently needed especially in developing nations. HIV vaccine study sites are needed in developing nations for more rapid development and deployment of vaccines. DNA plasmid vaccines are promising candidates - Their potency needs to be improved. The programme will explore various modes of increasing the immunogenicity of priming with plasmid DNA; intradermal injections, with GM-CSF as adjuvant, intramucosal injections and boosting with a Modified Vaccinia Ankara vector, MVA. Vaccines produced from subtypes appropriate for Tanzania will be used. A study site will be established in Dar es Salaam- The prerequisites for approval will be addressed on all levels, paving the way to future trials - Immunogenicity studies will continue in Dar es Salaam, with a focus on mucosal immunity and durability of the immune response.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bilateral Coordination for the Enhancement and Development of S&T Partnerships between the European Union and the United States of America' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

International cooperation plays an increasingly important role in tackling the major European and global challenges. The 7th Framework Programme (FP7) strongly emphasis international cooperation, increasing international collaboration is implemented by targeting Third Countries and fostering strategic Science &Technology (S&T) cooperation with key Third Countries such as the United States will be particularly needed. The BILAT-USA proposal will set up a sustainable, knowledge based, bi-regional dialogue platform between S&T key players as well as stakeholders from the EU-Member and Associated States and from the U.S. The project will strengthen S&T policies building on common interest and aiming at mutual benefit in order to strengthen the cooperation between EU and US. In line with the work programme to this call for proposals, this project will particularly focus on contributing to the implementation of the FP objectives by increasing participation of US researchers in the FP through a comprehensive approach in awareness raising, good practice sharing and effective dissemination activities. At the same time it will establish synergies with other ongoing projects and initiatives, in order to identify complementary opportunities and to contribute to the further development of the cooperation between the EU and US. The overall strategy of the work plan in this BILAT-USA proposal has been built on the following principles: - A consortium consisting of strong partners both in the EU and the US, who are key players in the field and are thus able to implement this ambitious work plan, - A comprehensive and clearly structured work plan devoted to achieve real results and impact; - A committed approach to networking at all levels: in the EU, in the US and with the actors invol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Next generation of AdVanced InteGrated Assessment modelling to support climaTE policy making' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

NAVIGATE aims to develop the Next generation of AdVanced InteGrated Assessment modelling to support climaTE policy making. It will critically improve the capability of Integrated Assessment Models (IAMs) to inform the design and evaluation of climate policies by targeting major advancements in two areas: describing transformative change in the economy, in technology and in consumer goods and services, and describing distributional impacts of climate change and climate policy. By tackling existing weaknesses and lack of capabilities of the current generation of IAMs, NAVIGATE will provide new insight into how long-term climate goals can translate into short-term policy action, and how countries and sectors can work in concert to implement the Paris Agreement. NAVIGATE is bringing together leading institutions in the field of integrated assessment modelling with leading domain experts. They will provide a broad and diverse collection of state-of-the-art tools ranging from domain specific models and data to an extensive set of flagship IAMs to foster a successful implementation of the project. NAVIGATE will engage in a concerted effort to increase the usability, transparency, legitimacy and hence uptake of IAM results. At the center of this will be a stakeholder dialogue to elicit user needs and engage in co-production of knowledge about IAMs and their uses. This will be accompanied by the development of methodologies to better assess the robustness of  IAM results, by extended model documentation and new communication tools, and by capacity building efforts to lower the entrance barrier to IAM activities for other research teams, including research teams in less-developed countries. The NAVIGATE partners have long-standing expertise in national, EU and international clima