RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Investigating virus-induced morbidity in filarial infections'.

assistant: **Objectives**

Filarial parasites cause over 200 million infections globally. Filarial morbidity was presumably limited to the skin, eyes, and lymphatic vessels. However, my research generated evidence that Onchocerca volvulus infection also induces neurological disease including Onchocerciasis-Associated Epilepsy (OAE). However, the causal mechanisms for neurological symptoms linked to O. volvulus infection are still unknown.Recently my research group co-discovered a virus (OVRV1) within O. volvulus. Being related to the rabies virus family, OVRV1 could potentially cause OAE. I will investigate the clinical implications of this virus in >1600 persons from 3 affected countries. Case-control studies will verify whether OVRV1 is a risk factor for OAE. In a cohort study of onchocerciasis-exposed children with neurological symptoms, I will investigate the presence of OVRV1 in cerebrospinal fluid and assess its neurotoxicity by seeding OVRV1-positive samples on neural organoids. Viral metagenomics on Mansonella perstans (most common filarial disease, >110 million infections) will determine if it also harbours OVRV1 or other viruses. Finally, I will establish a prospective pregnancy cohort (n=900) and follow-up their children to investigate the materno-foetal consequences of in utero exposure to filarial parasites and/or viruses.This project is expected to unveil new disease mechanisms and may lead to new diagnostic/treatment options. If OVRV1 is shown to be associated with OAE, it could serve as a biomarker to diagnose this condition. However if OVRV1 is found to be an O. volvulus-specific endosymbiont, it could be used to improve the performance of the current onchocerciasis diagnostic tests. It could even become a target for the development of new (macro)filaricidal drugs. Demonstrating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Anaerobic Biotechnology for Sewage Sludge Treatment: Integrating Anaerobic Bioleaching with Anaerobic Digestion' (AnBIOSST) under Horizon 2020.

assistant: **Objectives**

During wastewater treatment, a significant amount of sewage sludge (SS) is generated as a by-product, with an estimated production in Europe alone of 2 bio tons/yr. SS use as fertilizer and anaerobic digestion are 2 disposal routes that comply with current legislative guidelines on waste disposal and environment. Anaerobic digestion (AD) is widely applied, resulting in volume reduction and biogas production. However, high heavy metal (HM) contents in SS impede the use of raw SS or AD effluent to be used as fertilizer.Bioleaching is based on the activity of Fe-and S-oxidizing microbes, capable of degrading metal sulfides and solubilizing HM. Because of its potential to remove HMs from solid matrices, bioleaching has been considered as a promising technique for both raw SS and AD effluent.  In this regard, studies have been performed on conventional oxidative bioleaching approach (OBL). However, the rate of HM dissolution through OBL is slow, it requires aeration and addition of leaching agents (acids, bases, etc), which increases costs. Also, the inevitable formation of by-products limits the process efficiency. Recently, anaerobic bioleaching (ABL) has been a choice to recover HMs of different sources,with benefits of acid production and minimization of by-products. However, up to now, ABL has not been introduced in SS treatment. Furthermore, the application of ABL to sewage sludge prior to AD digestion offers various potential advantages: (i) the bio-availability of HM (which serve as micronutrients to AD microorganisms) is increased, (ii) volatile fatty acids (VFA), very important AD intermediates, are produced; and (iii) the sludge is already in a reduced state before in enters the digesters.In this research project, we will obtain essential knowledge about (1) ABL a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Euro-cg00', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The European Workshop on Computational Geometry is planned to take place in Eilat Club Hotel, Eilat, Israel, in March 2000. Computational Geometry is a young and already established research area within Computer Science. It deals with a wide spectrum of geometric algorithms, their efficiency and combinatorial complexity, as well as practical issues like computational robustness, when implementation of geometric algorithms is applied to large practical problems arising in industrial applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of persistent neurological complications after eclampsia and discovery of novel neuroprotective treatments to improve maternal outcomes', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The goal of this project is to define neurological outcomes after eclampsia and to determine underlying pathophysiological pathways to eclampsia which will lead to new drugs for neuroprotection of the maternal brain.Preeclampsia and eclampsia are the most common causes of direct maternal death globally. Magnesium sulphate is the only treatment in use but it has serious side effects, only protects from seizures in 50% of cases and neuroprotection on longterm is not established. Women with eclampsia run an increased risk of longterm neurological sequelae but causality with the acute insult is not proven. There is an urgent need to understand this relationship and underlying pathophysiological pathways to identify how the acute injury affects the chronic sequelae and identify new targets for neuroprotective drugs. I want to respond to this need by determining recovery from the acute cerebral complications of eclampsia to follow up 6 months postpartum and characterize and identify pathways for neurological injury secondary to eclampsia. This will be achieved by investigating mechanisms of blood brain barrier injury, cerebral blood flow autoregulation, neuroinflammation, cognitive function deficits and white matter scarring in the brain. I will make use of a cohort of women with eclampsia from my site at Stellenbosch University, South Africa, as well as a rat model of preeclampsia and an in vitro model of preeclampsia in my lab at the University of Gothenburg, Sweden, to evaluate these outcomes. I will use anti-diabetic and anti-epileptic drugs commonly used in pregnancy and test these in rat model of preeclampsia to find new neuroprotective treatments that improve maternal outcomes. This could enable us to protect the maternal brain, save lives and reduce morbidity globally
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Case-control study of selected second cancers following breast cancer. Influence of tamoxifen and other treatment modalities'.

assistant: **Innovation**

The objectives of EuroDeucaTam Project are to evaluate the potential carcinogenic risks linked to several treatment modalities for breast cancer. In particular, the study will quantify any increases in selected second cancers following breast cancer. For the period 1996-1998, the study will concentrate on cancers of the endometrium, ovary and liver following breast cancer. It will determine the etiological role of all reproductive variables, other variables known to be associated with risk of breast cancer and of the other tumour under study, and of primordial interest will be the assessment of the effect of the various treatment modalities of breast cancer (surgery, radiotherapy, chemotherapy and hormonotherapy). The main exposure under study will be tamoxifen, with a detailed evaluation of the effects on risk of daily dose, duration of treatment and the interaction with other treatments radiotherapy, chemotherapy, and castration with evaluation of its effects according to method used (radiotherapy versus surgery). The methodology used will be that of case-control studies. The cases will be women developing the second cancer of interest after having had breast cancer. Breast cancer diagnosis should have been made after the introduction of tamoxifen in the country concerned (1976). The source of cases on referents will be population-based cancer registries (to avoid biased ascertainment of cases and referents). The two diagnoses (breast cancer and second cancer) will have been recorded by the participating cancer registries. There will be four controls for every case. These will be women diagnosed with breast cancer at the same time and in the same registry as the case. They will be matched for age (+ 2 years) and date of breast cancer diagnosis (+ 2 years) with the cas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'All-liquid phase JANUS BIdimensional materials for functional nano-architectures and assemblies'.

assistant: **Innovation**

Asymmetry is a key structural feature in natural systems and allows for self-organization and unidirectionality of chemical transformations. JANUS BI aims at developing an innovative protocol for the production of 2D materials bearing different functionalities on the two opposite sides. The challenge is to implement the full process in the liquid phase and thus not resorting to solid phase transfer techniques, which is the current state-of-the-art. With this new method, Janus 2D material colloidal inks can be directly produced and used as they are, or for further solution processing of thin-films and/or more complex architectures. The core of the project is the challenging protocol proposed, which rely on the versatility of liquid phase exfoliation (LPE) of 3D crystalline powders of intrinsically layered species to produce 2D material inks and on the large availability of chemical functionalization approaches for 2D materials, both aspects being soundly mastered by the PI of JANUS BI. A first exfoliation produces quasi-2D nanosheets, which are a-selectively functionalized with bulky groups so as to completely cover the exposed faces. The functionalized quasi-2D objects are then subjected to further LPE, providing single-faced functionalized 2D materials. A second functionalization step is forced to happen on the un-covered face, due to the steric hindrance of the pendant functionalities present on the other. The setting-up of a similar protocol requires a tight control over the nanochemistry and nanomorphology of the substrates employed, resulting in a substantial gain of knowledge in controlled functionalization processes for 2D colloids. Once the guidelines for its successful implementation are identified, the development of a whole library of Janus 2D inks is enabled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Light and sound waves in silicon and nonlinear glass waveguides' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The interplay of light and sound waves in matter has attracted the attention of researchers for decades and has found many technological applications. Photonic integrated circuits (PICs) provide an exciting playground for such investigations, due to wavelength-scale guiding structures, periodicity in one or two dimensions, and high-quality resonance structures. The objectives of this proposal are to introduce, investigate and employ interactions between guided optical modes and hyper-sonic acoustic waves, within PICs in silicon and in chalcogenide glass media. Both these platforms are extremely important: silicon for its potential for integration of photonics and digital micro-electronics and mature fabrication technology, and chalcogenides for their unique nonlinear-optical and photo-sensitive properties. However, the introduction of hyper-sonic acoustic waves to both materials is highly challenging, due to the absence of piezoelectricity.To address these challenges, this project is based on developing and validating two alternative methods for the generation of high-frequency acoustic waves. First, photo-acoustic absorption of intense, ultrafast laser pulses by periodic, metallic patterns will be employed. The technique is being used in bulk silicon substrates, and will be carried over and adapted for use in silicon and chalcogenide glass PICs. Second, carefully controlled stimulated Brillouin scattering (SBS) processes will be used to excite acoustic waves along chalcogenide PICs in a highly localized fashion.Prospective outcomes include new fundamental insights into the opto-mechanical properties of materials, films and periodic structures; novel functionalities of silicon and chalcogenide PICs, such as acousto-optic modulation, dynamic gratings and elasto-optic sup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Contextualizing biomolecular circuit models for synthetic biology' under Horizon 2020.

assistant: **Concept**

Synthetic biology is the bottom-up engineering of new molecular functionality inside a biological cell. Although it aims at a quantitative and compositional approach, most of today’s implementations of synthetic circuits are based on inefficient trial-and-error runs. This approach to circuit design does not scale well with circuit complexity and is against the basic paradigm of synthetic biology. This unsatisfactory state of affairs is partly due to the lack of the right computational methodology that can support the quantitative characterization of circuits and their significant context dependency, i.e., their change in behavior upon interactions with the host machinery and with other circuit elements.CONSYN will contribute computational methodology to overcome the trial-and-error approach and to ultimately turn synthetic circuit design into a rational bottom-up process that heavily relies on computational analysis before any actual biomolecular implementation is considered. In order to achieve this goal, we will work on the following agenda: (i) develop biophysical and statistical models of biomolecular contexts into which the synthetic circuit or synthetic part can be embedded in silico; (ii) devise new statistical inference methods that can deliver accurate characterization of circuits and their context dependency by making use of cutting-edge single-cell experimental data; (iii) derive new context-insensitive circuit designs through in silico sensitivity analysis and application of filtering theory; (iv) optimize protocols and measurement infrastructure using model-based experimental design yielding a better circuit and context characterization; (v) experimentally build synthetic circuits in vivo and in cell-free systems in order to validate and bring to life the a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The impact of literary translation funding on the transnational mobility of minor European literatures.' to be submitted under Horizon 2020.

assistant: **Abstract**

This project will investigate the rationale, function and impact of funding for the translation, publication and promotion of European literature. State, supranational and third-sector structures for funding translations have been in place for several decades across Europe, promoting literary and cultural diversity. Applying sociological tools to translation, literary and cultural studies, this research will analyse how recent and current schemes inform practical decisions on acquisition, publishing and marketing strategies by target publishers across multiple European countries.The research is a quantitative-qualitative mix focusing on the sorely under-researched area of less translated European literatures. A historical survey of past translation measures and outputs against the backdrop of cultural, economic and political developments in Europe since the 1970s will form the springboard for the qualitative part of the project. Using semi-structured interviews, it will explore the decision-making process of acquisition editors in the target publishing houses and the function of translation funding measures across multiple European countries.A better understanding of the practical mechanisms that support the cultural and literary diversity in Europe will help identify the current shortcomings and future shape of policy and practice. By combining his experience of professional and scholarly contexts, the applicant will generate a deep, two-way transfer of knowledge and restart his career by radically expanding his research profile and capacity. This research will, moreover, contribute fundamentally to the sociology of literature, book history, translation, policy and international relations research, and potentially transform professional practice and the thinking of pol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Premenopausal prophylactic oophorectomy - effects on psychological symptoms sex life and quality of life' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objective of the research project is to estimate the effects of premenopausal prophylactic bilateral oophorectomy on psychological symptoms (depression, anxiety), health related quality of life, and sex life. The study is a rigorous systematic review of existing scientific literature, utilizing up-to-date methodology to eliminate bias. Use of hormonal replacement therapy is taken into account as a major modulating factor of the effects. The unbiased retrieval of the research reports is guaranteed by the use of comprehensive prospective registers, reverse searching", searching "grey literature", handsearching and contacts with research institutions. The validity of the studies will be assessed by use of pre-existing, design-specific quality instruments. Fixed effect meta-analyses, including homogeneity tests and sensitivity analyses, will be used to quantitatively combine estimates on comparable outcome variables. The report will be prepared with special emphasis on clinical relevance. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Open-loop solutions for package glass recycling'.

assistant: **Concept**

European countries with no wine production import considerably more package glass than they can recycle in current closed- or open-loop solutions. In case of Stenberg-Yhtiot Oy, a glass collecting and sorting plant, it is essential to find new open-loop markets for recycled glass. Present markets can be greatly broadened by utilizing the recycled glass as a valuable raw material in the production of building elements, tiles, concrete blocks and castables. The objectives of the project are: (1 ) to find the requirements for the recycled glass treatment, especially for the particle size distribution, (2) find the additives to prepare a workable mixture, (3) optimise the production technology for tiles, concrete elements and castables, (4) harmonize the technical specifications of the products and (5) develope end-products with high added-value. The advantages of the project are: (1 ) substantial increase in recycled glass utilization, (2) lowering of rawmaterial costs, (3) broadening the usability of castables-technology and (4) showing a true realisation of the principles of sustainable development (with up to 99% usage of recycled materials in the product). The consortium is comprehensive including both the raw material supplier (Stenberg-Yhtiot Oy who takes care of recycled glass collecting and its treatment) and the building element producers: tiies (Woolliscroft), concrete elements (Partner 4) and castables (ABR Innova Oy). European countries with no wine production import considerably more package glass than they can recycle in current closed- or open-loop solutions. In case of Stenberg-Yhtiot Oy, a glass collecting and sorting plant, it is essential to find new open-loop markets for recycled glass. Present markets can be greatly broadened by utilizing the recycled