RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Early Stage Training in Molecular Imaging Techniques' (2002-2006).

assistant: **Concept**

Recent advances in imaging technologies and the development of several fluorescent proteins and activatable fluorochromes have opened the field of Molecular Imaging, constantly gaining importance in the area of Life Sciences. Compounds exhibiting fluorescent properties recently play a major role in many biotechnology applications such as gene expression profiling, determining protein function as well as in revealing cellular pathways and sensing small-molecule protein-protein interaction.Due to its multidisciplinary nature, Molecular Imaging science is constantly under expansion, exploiting existing imaging techniques as well as new tools that have become available. In order to reach its main goals of sensitivity, specificity and resolution in a large variety of molecules, organs and species, experts dedicated to the field of Molecular Imaging are needed. In order for Molecular Imaging to evolve efficiently, multidisciplinary knowledge needs to be delivered at the early stage of training combining the different disciplines in a coherent way and not separately as is currently being done.Within this site we propose to offer young researchers the opportunity to gain experience in all the different disciplines present in Molecular Imaging, by interacting with experts from fields such as Biology, Physics, Mathematics and Computer Science all located in the same campus. All training will be devoted and oriented to the different aspects that surround Molecular Imaging techniques. The users of this site will be offered the opportunity to be involved in state-of the art research and gain multidisciplinary knowledge coherently oriented towards Molecular Imaging.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Endocrine control as a determinant of larval quality in fish aquaculture' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Many aspects of development, differentiation and metabolism in vertebrates are regulated by small biologically active molecules such as thyroid hormones and retinoids. They act via a family of intracellular receptor proteins which act directly on target genes. Thyroid hormones are passed on to the eggs by broodfish prior to spawning (Kobuke et al., 1987; Tagawa and Hirano, 1987; Brown et al., 1987; Greenblatt et al., 1989, Tagawa ef al., 1990) and may provide the necessary physiological regulation for growth, development and osmoregulation in larvae prior to the functional development of their own endocrine glands. There is little doubt that thyroid hormones are essential for fish development, for example, in the metamorphosis of the flounder (Miwa et al. 1988; Yamano ef al. 1994). Also, treatment of larvae from several species with thyroid hormone has beneficial effects on development and survival (Brown and Nunez, 1994) and it has recently been shown that thyroid hormone receptors are abundant in sea bream larvae (Llewellyn et al., 1996). However, the investigations into thyroid hormones so far have centred on hormonal measurements or treatments and have not attempted to identify the tissues, which respond to these hormones during development by detecting the presence of specific receptors in those tissues. Growth hormone (GH) is one of the major hormones regulating growth in vertebrates. However, despite evidence that GH cells are present (Power and Canario, 1992; Cambre et al., 1990) and GH is synthesised in recently hatched fish (Funkenstein et al., 1992) and that, in the Japanese flounder, GH expression increases throughout metamorphosis, the functional importance of GH in fish larval development remains to be ascertained.The prime aim of the project is to establi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'MONSOON ASSEMBLAGES'.

assistant: **Innovation**

The ambition of this cutting edge research project is to deliver a ground breaking, interdisciplinary design-driven inquiry into the impacts of changing monsoon climates in four of South Asia’s rapidly growing cities. This will be undertaken at a time when climate change and urban development conspire to produce unlikely futures for urban survival. Extreme weather events, all attributed to the monsoon’s capricious nature, are resulting in increasing frequency in water shortages, power failures, floods, out-breaks of disease, damage to property and loss of life. In responding to these events, the project will challenge the dominant view of the monsoon as a natural meteorological system outside of and distinct from society. Instead it will propose that the monsoon is a co-production of physical and social dynamics entangled within historic lived environments that can be analyzed, worked with, shaped and changed. To do so, an unconventional interdisciplinary team will develop a novel research methodology around the new operative concept of ‘monsoon assemblages.’ This will bring together the spatial design disciplines with the environmental humanities to advance research of lived environments as indivisibly natural, social and political and to propose models for intervening in them through design. The project aims to shift conceptions and understandings of the monsoon as a natural meteorological system; to deliver a ground breaking new approach to the design of cities by treating the monsoon as an organizing principle of urban life, not an external threat; to assess the potential impact of this approach for urban policy, planning and infrastructure investment; to assess the new political, theoretical and aesthetic agendas for the spatial design disciplines and the environme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A novel system for prressure casting of ceramic products with maximum flexibility of manufacture' under Fifth Framework.

assistant: **Concept**

The FLEXIFORM project addresses the problems of inflexible manufacturing and slow introduction of new product shapes in ceramic manufacture. The objectives are:a) to demonstrate a new concept in pressure casting machines;b) to develop a novel mould material that can be CNC machined and;c) to combine electrokinetic assistance with pressure casting.These objectives will be achieved by:a) designing, constructing and operating pressure casting machines on two tableware and one sanitary ware factories;b) laboratory research to develop and evaluate the new mould material and c) factory simulation modelling to demonstrate the commercial and financial advantages offered by the new mould/machine system.Expected results are:a) a fully proven pressure casting machine technology;b) a novel mould technology;c) factory simulation models for process integration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantum phases and disorder effects in ultra-cold quantum gases' to be submitted under Sixth Framework.

assistant: **Abstract**

Ultracold bosonic and fermionic quantum gases are robust systems for probing fundamental condensed-matter physics problems as well as finding applications in quantum optics and quantum information processing and understanding atomic and molecular physics.The proposed research Project deals with the theoretical investigation of novel quantum phases and disorder effects in ultracold bosonic and fermionic gases with low-dimensionality, through the development and combination of analytical and numerical approaches.The objective is to analyse disorder effects on transport and other measurable properties of atomic gases in optical lattices with strong repulsive interactions. The innovative aspect of the Project relies on the application of research methodology known in condensed-matter physics to atomic and molecular physics systems.The training objectives of the Project include advancements of research skills and expertise of the fellow in the field of atomic and molecular physics by developing new and successful methodology to the study of ultracold quantum gases.It will add different/complementary scientific competencies to the fellow background in the process of reinforcing her position of professional maturity and independence offering an advanced training in multi-disciplinary field. It will permit the fellow to undertake transnational mobility appropriate to her individual needs, directed towards competence diversification.As long term potential benefit, the fellowship will offer the fellow the opportunity to continue her work in the same research field by creating her own research group. It will contribute to reinforce and increase the place and role of women in science, both from the perspective of equal opportunities and in positively addressing a shortfall in the n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The role of genetic redundancy in adaptive evolution of efflux pumps'.

assistant: **Innovation**

In genetic redundancy, multiple genes in a genome perform the same or similar function. Although redundancy is widespread across the tree of life, its evolutionary origins are not entirely understood.  Genetic redundancy may provide a fitness benefit during evolution by increasing gene dosage and protecting critical genes from deleterious mutations. These fitness effects have been confirmed experimentally, but their long-term consequences for evolution have not been tested. In this study, I will manipulate the genomic content of efflux pump genes in E. coli and test the effect of their redundancy using directed evolution of proteins. By evolving the multidrug efflux pump AcrAB at different levels of redundancy, I will determine how the presence of other genes with overlapping drug-efflux activities affects adaptive evolution. I will compare evolutionary trajectories using comprehensive sequence and fitness analysis of the evolved efflux pump variants. This approach will provide a unique opportunity to directly test the role of genetic redundancy in evolution and help to understand why genetic redundancy is maintained in a genome.


**Keywords:** Genetic redundancy, Efflux pumps, Antimicrobial resistance, Gene duplication, Directed evolution of proteins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Detection of membrane-interacting cytotoxic amyloid intermediates with novel fluorescent probes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Formation and deposition of fibrillar protein aggregates (amyloids) is a fundamental feature of neurodegenerative diseases. It has been suggested that neurotoxicity in Parkinson’s disease originates from the binding of α-synuclein (AS) oligomers to cellular membranes, resulting in bilayer disruption and leakage. Membrane binding is also presumed to be involved in the (as yet unknown) physiological function(s) of AS. Thus, it is essential to assess: (i) the diverse conformational states of AS bound to membranes; and (ii) whether in-situ (on-membrane) formation and/or binding of the “toxic” (pre)amyloid-AS leads to specific membrane damage and ultimate neuronal death. Studies addressing these issues have been hampered by the lack of probes able to monitor conformational states, the binding of different protein forms to membranes, and the early stages of aggregation. The aim is to identify and characterize aggregation intermediates of AS having the highest membrane-disruptive ability potentially responsible for toxicity. The focus will be on the binding of monomeric and pre-aggregated forms of AS labeled with a newly developed class of ratiometric Excited State Intramolecular Proton Transfer (ESIPT) probes. These dyes, 3 hydroxychromones, exhibit a dual emission exquisitely sensitive to the molecular microenvironment and will thus discriminate changes in lipid environment and protein states (conformation, association) as a function of (different) lipid composition and conditions. The host lab has already shown that ESIPT probes are very effective in solution studies of AS aggregation. In the project, I intend to monitor AS interactions with synthetic and cellular membranes by expression probes based on ESIPT and other environment sensitive dyes, which I will develop, optim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Greenhouse film covers with tailor-made properties for enhanced performance' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

FILMCO by Elysee Irrigation Ltd. – a Cyprus-based manufacturer and worldwide supplier of piping and irrigation systems foragricultural, domestic and public use - will bring to the market a high performance film cover for greenhouses based in nanomaterialstechnology, offering significant benefits to growers due to the use of advanced polymer nano-composites. FILMCOis a greenhouse film that has already probed to provide the growers with energy consumption savings by 24-28%, andincrease their crop production by 20%. FILMCO’s main innovation is the ability to regulate the Photosynthetically activeradiation (PAR) for a given Infrared Radiation (IR), thus controlling the degree of rightness/darkness according to thelocation requirements. The novel film will have increased robustness, added to higher pesticide and UV and oxidationresistance. The film will create a controlled environment in the greenhouse while lowering energy demands, reducing costsand promoting a better use of resources and higher crop yield. The longer lifespan will also reduce plastic waste anddecrease waste management expenses. Although nanotechnology has emerged in industrial applications over the lastdecades, there is no similar commercial product available in the growing greenhouse agriculture market that matches thebenefits and competitive advantages of FILMCO. FILMCO, with TRL 6, is the outcome of a national research project inwhich Elysee already demonstrated these promising results benefits for growers, so it became a success history. ViaFILMCO, Elysee estimates a new revenue stream valued at 13.7M€ over the first 5 years of commercialisation, and also willhire 10 new employees for the production line. The feasibility assessment will address both, business and technologicalaspects, aiming to obtain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Yamatology of the Axis. Japan as a Nazi-Fascist Utopia of Political Renewal' (YTOPIA).

assistant: **Innovation**

After his arrest for mass murder, the Norwegian terrorist Andres Breivik declared “that a Japanese would understand him a lot better than any European would”, because “the Japanese understand the idea and values of honour”. Shortly before committing suicide in the Notre Dame Cathedral in Paris on 21st May 2013, the French new right thinker Dominique Venner wrote a book in which he depicted himself as a ‘samurai’ who fought in defence of European identity. These are just two of the many examples of the role played by a certain image of Japan in far-right imagination of our time. This project investigates the origins and development of the political discourses on Japan – something that can be called ‘yamatology’ instead of japanology – by focusing on the historical moment in which they reached its wider dissemination and became integral parts of far-right ideologies. The aim of this project is, therefore, to analyse comparatively the discursive construction of the image of Japan in Nazi Germany and Fascist Italy. Instead of offering an overview on the European representations of Japan or focusing on a national case study, this project will carry out a detailed analysis of Nazi-Fascist yamatological representations, by considering them as result of a dialogical interaction between European and Japanese actors, as well as a constituent element of the Axis’ cultural policies closely related to many of the ideological features shared by both Fascism and Nazism. The project’s ultimate goal is to highlight the utopian dimension of yamatological representations, in which Japan – just like it did for Breivik or Venner – became the projection surface for far-right values and political aspirations. In doing so, this project allows re-thinking of the nature of fascism, both stressin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Theranostic Peptide Tracers for Breast Cancer' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Breast cancer impacts one in eight women globally, resulting in over half a million deaths each year. Current diagnostic methods fall short, with ~40% of breast cancers having already spread at the time of diagnosis and mammography often producing high rates of false positives. Additionally, there is a lack of reliable tools for monitoring treatment responses, tracking recurrences, or providing real-time tumour visualisation to aid surgical tumour removal.This project addresses these challenges by developing theranostic peptide tracers targeting the oxytocin receptor (OTR), a promising new target for imaging, diagnosis and treatment of breast cancer. OTR is highly overexpressed in primary breast cancers, including metastatic and triple-negative cases, which remain difficult to treat. Our team has successfully developed potent, OTR-specific peptide tracers capable of visualising OTR in cells and tissues. Building on this progress, the project will refine and expand the design of these tracers and provide proof-of-concept data that they can be used to efficiently visualise and remove breast tumours.Expected outcomes include theranostic tracers that can enhance breast tumour detection, support breast-conserving surgical tumour removal, and targeted radiotherapy, including subtypes that currently do not have targeted approaches. This combined approach of improved detection and targeted therapy has the scope to considerably enhance patient care, treatment options, and survival rates while reducing healthcare costs. The development of these tracers, supported by preclinical data and intellectual property protection, is expected to attract further investments and foster industry partnerships to accelerate clinical translation.


**Keywords:** peptide tracers, theranostics, can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular bases of human excitatory neurotransmitter transport across the plasma membrane' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The paramount importance of human membrane proteins for life contrasts with the lack of understanding of their molecular mechanisms of function and pharmacology. This project focuses on the molecular mechanisms of one of the most important and medically relevant families of neurotransmitter membrane transporters in the brain, the Human Excitatory Amino Acid Transporter (hEAAT) family. Glutamate is the main excitatory neurotransmitter in the brain and its extracellular concentration is mainly regulated by the hEAATs, which pump the transmitter into the cytoplasm of cells. This role is essential to neurological processes like memory, cognition, and learning. Importantly, glutamate can also be a potent neurotoxin and the deregulation of its extracellular levels is associated to numerous neurodegenerative and mental disorders. We aim to characterize the molecular function and pharmacology of the hEAATs using a broad multidisciplinary biophysical approach to obtain and integrate structural, energetic and dynamic information on these human membrane proteins. We will develop new methods to obtain for the first time the hEAATs in pure and stable form for rigorous biophysical analysis and generate a library of new selective compounds with pharmaceutical potential that target the transporters. This knowledge will be essential to gain a complete understanding of hEAATs function and to design new therapeutic and pharmacological strategies to alleviate the impact of common neuropathologies. Finally, the methods that we will develop for the hEAATs could be applied to other families of human membrane proteins and will help to bring our knowledge on membrane proteins to the human level.