RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'WFD meets CAP- Opportunities for the future'.

assistant: **Objectives**

Water pollution caused by agricultural activities stays one of the most important environmental cerns in the developed countries. On the one hand, agricultural land-use is one major drivers for water pollution and often impedes the achievement of the primary goal of the Water Framework Directive - to achieve the andquot;good statusandquot; of water quality. On the other hand, agricultural production depends strongly on the availability of sufficient water. Although the physical links between agricultural land-use, soil and water pollution are well known, at the political level these fields are mainly dealt with independently and co-operation possibilities are currently mainly unused. In addition, the implementation shortcomings between both policy objectives and actual outcomes is a recent issue on the environmental policy agenda. The implementation of the Water Framework Directive depends strongly on agricultural land use and therefore, on the forthcoming reform process of the CAP, a more environmental friendly agricultural production is needed. Current transformations in both policy fields, the Common Agricultural Policy reform and the new Water Framework Directive, offer a potential to combine the efforts of the two policies that should be used. The ference and the Policy Briefs under the Specific Support Action andquot;CAPandWFDandquot; aim to initiate a process in order to achieve the best synergies between the CAP and the WFD, bringing together the policy makers, decision makers, stakeholders and scientists from both policy areas in order to reach a better understanding of both sides and to develop a common language. Further, the currently unused co-operation and co-ordination opportunities will be identified and further developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Stimulating and facilitating the participation of European researchers in Korean R&D programmes' (KORRIDOR), addressing dissemination and exploitation.

assistant: **Impact**

Korea is one of the global leaders in Science and Technology, one of the most important RTD partners of Europe with well established legal frameworks for cooperation. At the same time, the level of public awareness of cooperative opportunities for European researchers in Korean RTD and Innovation Programmes (directly foreseen by the EU-Korea Science and Technology Cooperation Agreement) is still very low. Thus, the overall project goal is to widen and strengthen the RTD cooperation between Korea and the EU in the area of common research interests by opening up access opportunities for European research groups in Korean national research and/or innovation programmes. The project objectives will be attained by carrying out the following set of activities: - opportunities mapping study, which will provide information on existing access opportunities and policy recommendations to improve them - targeted dissemination to raise public awareness in Europe of Korean science system and its opportunities for doing joint research (incl. visibility at major European events, large-scale dedicated Conference, etc.) - facilitation and capacity building measures aiming at creating sustainable structures for bilateral cooperation fostering, monitoring and evaluation. The project consortium composed of major Korean RTD implementation agencies, largest European RTD umbrella organizations (DLR and CNRS), and headed by Korean Institute of Science and Technology in Europe has all capabilities to bring about the expected impacts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Visualising transport dynamics of transmembrane pumps'.

assistant: **Objectives**

The project will investigate multi-component molecular machines that drive substrates across the cell envelope of bacteria. Some of the machines pump antibiotics or toxins, and so contribute to drug resistance and virulence in pathogenic strains. Questions that will be addressed include what the molecular pumps look like, how they are assembled and regulated, how they capture and translocate substrates, and the stereochemical basis for the cooperative switching of substrate-binding states. Molecular pumps that will be studied include tripartite systems driven by ATP hydrolysis, which play a central role in the efflux of macrolide antibiotics and secretion of toxins in Gram-negative bacteria, and those that use secondary transporters energized by electrochemical gradients. We will build upon our earlier observations to prepare a series of intermediates encompassing the key steps in the transport processes, to visualize tertiary and quaternary structural changes, the pathway of substrates in the efflux pumps, and the threading of toxin polypeptides through the constricted channel in the secretion assembly. The pumps and secretion systems cycle through intermediate states, and these will be studied at high resolution by cryoEM and crystallography to understand how the conformational states switch with strong cooperativity and avoid futile cycles that dissipate energy. Our work indicates that the activity of these transporters can be modulated by small peptides and potential co-factors, and we will address how these work. The project will build on our novel approach to engineer the pump assemblies that enables structural analysis at high resolution in isolation and in situ, and will be complemented with mechanistic analyses in vitro and in vivo. The project will deliver a c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Impact of Climate Change on the Southeast Asian Monsoon' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Changes in Asian monsoon variability can affect more than 50% of the world population, yet our understanding of the monsoon is incomplete. The proposed research will bring new insight into this crucial component of the Earth’s climate system while using world-class equipment and resources available at the host institution, the University of Oxford. This research will contribute to a deeper understanding of a critical but understudied portion of the Asian monsoon, the Southeast Asian monsoon, by producing a high-quality climate reconstruction using speleothems (cave carbonate formations) from Laos. Speleothems are widely considered as one of the best climate archives available. They can be precisely dated and their geochemical composition preserves long and detailed information of past climate change. I will capitalize on these properties of speleothems to address key questions regarding past variability of the Southeast Asian monsoon: (1) What is the long-term history of the Southeast Asian monsoon, and how does this compare to records from the South and East Asian monsoons? (2) Are recent changes in the relationship between El Nino and the monsoon a response to global warming? (3) Are changes in Southeast Asian monsoon strength driven from the northern or southern hemisphere? (4) Can comparison of oxygen isotope records along moisture transport pathways provide quantification of past rainfall? The societal and economic implications of climate change ensure that understanding the behavior of the climate system will continue to attract widespread research, together with public, economic, and government interest, for decades to come. Moreover, an understanding of the mechanisms of climate change that impact the Asian monsoon region, as proposed here, is essential for scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transforming Growth Factor – Bench To Bedside. Towards a better understanding of TGF-β isoform specific signalling in health and disease' (TGF-BTB) targeting Horizon 2020.

assistant: **Abstract**

TGF-BTB (Transforming Growth Factor – Bench To Bedside) is an ambitious and innovative project, the goal of which is to not only to understand the different roles of the TGF-β isoforms as well as in cell signalling at a molecular level, but also to explore their critical roles implicated in pathogenesis of fibrotic disorders and cancer. The dysregulation or complete shutdown of TGF-β pathway is responsible for many human diseases including connective tissue disorders, fibrotic disorders and the initiation and progression of soft tissue cancers. Most recent data show the importance of TGF-β in controlling the tumor microenvironment and its significance in the course of anticancer immunotherapies. The project will employ methods of structural and cell biology, together with in silico simulations, and will include the development of new tools, such as isoform-specific peptide-based inhibitors, engineered cytokines to study and manipulate the TGF-β canonical and non-canonical pathways. TGF-BTB is not only of great importance for increasing basic mechanistic understanding of TGF-β signalling, but also in terms of discovering potential new therapeutic avenues for treating diseases driven by excessive TGF-b signaling. During the outgoing phase, The Fellow, Dr Łukasz Wieteska, will join Prof Andrew Hinck’s research group at the University of Pittsburgh, which is a world class research laboratory at the forefront of TGF-β family structural studies. the Fellow will return to the University of Leeds to  continue his work with Prof John Ladbury, whose research has a strong focus on exploring the structural, biophysical, and cellular outcomes of the interplay of protein receptors in cell signalling pathways. Upon return, the Fellow will also benefit from a secondment at The Francis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'TechTissue - Validate human-based 3D in vitro models for accurate drug discovery and development towards a successful market entry'.

assistant: **Concept**

Metatissue is focused on the design, production and commercialization of chemically modified human-derived proteins to prepare hydrogels, sponges and bioinks to improve 3D cell culture and disease modelling for drug discovery and development, tissue engineering, and personalized medicine advancements.Metatissue has developed a bioactive platelet-rich plasma derivative precursor that can be cured upon light exposure to form soft materials with tunable mechanical properties. Such materials provide functional support for cell growth and interact with cells to control their function, guiding the process of tissue morphogenesis. This platform is the first to offer complete human-based material for 3D cell culture and an easy-to-use solution for clinical purposes.This deep technology enables researchers to culture human cells in a physiologically relevant microenvironment for applications in cell culture research, drug screening and development, cancer research, tissue engineering, replacement of animal testing and therapeutic applications. This technology will have a significant impact on the 3D cell culture market and pharmaceutical industry by accelerating drug screening and development reducing associated costs.These materials present an alternative to the gold standard materials that are currently used in cell culture assays, which generally comprise animal-derived proteins that form a gel under corporal conditions. TechTissue intend to achieve the current Metatissue strategy by exploiting its business opportunity and setting a successful business strategy and commercialization plan based on the technical optimisation of the product, the assessed market requirements, the end-user needs and the competitor analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European multicentre project on coeliac disease and non-hodgkin lymphoma' (1994-1998) under Fourth Framework.

assistant: **Objectives**

ObjectivesTo evaluate whether in Europe untreated coeliac disease is a primary risk factor to develop cancer, in particular non-Hodgkin lymphoma at any primary site, and to quantify the relative risk. To determine whether patients with coeliac disease who develop non-Hodgkin lymphoma are genetically different from those who do not.Coeliac disease (CD) is a permanent intolerance for proteins of grains (wheat, rye, barley and possibly oats) called gluten, characterized by villous atrophy of the small intestine. The disease is treated with a gluten-free diet. The incidence of diagnosed CD in Europe is about 1: 2000 live births. Typical cases manifest with chronic diarrhoea, weight loss and abdominal distension. However, the clinical spectrum of CDis highly heterogeneous and many CD cases present with extra intestinal complaints, such as anaemia, short stature, pubertal delay, osteoporosis or neurological disorders. Sometimes CD is clinically silent. The widespread use of CD screening tests (determination in serum of IgA antigliadin and antiendomysium antibodies) has shown that, in most European countries, the number of CD cases which remain undiagnosed anduntreated is, much higher than the number of patients who are correctly diagnosed on clinical ground. A recent Italian multicentre survey on 17,201apparently healthy students showed a prevalence of CD of 1 in 184 subjects, with a ratio of 1:7 recognized versus unrecognised CD cases. These results indicate that in Europe CDis one of the most common lifelong disorders.Persons with CD have malignancies, especially of the gastrointestinal tract, at a significantly higher frequency than the general population: 8.1-13.3% of the patients develop cancer. In CD there is a 43-fold relative risk (RR) for non-Hodgkin small bowel Iymp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A combined photoelectrochemical and fluorescence imaging system for investigating nanoparticle-cell interactions' under Horizon Europe.

assistant: **Concept**

Nanoparticles (NPs) have become increasingly attractive for biomedical applications such as targeted drug delivery, cancer therapy,and bioimaging due to their excellent properties. The investigation of NP-cell interactions (cellular uptake and cytotoxicity) is crucialto the development of safe and effective use of NP in living organisms. However, current methods for studying NP-cell interactionsrely on fluorescence microscopy, and complementary methods need to be done separately. Therefore, we propose to develop a novelimaging system that can conduct label-free photoelectrochemical imaging and fluorescence imaging simultaneously so that electrical signals from the basal side of cells and fluorescence signals can be obtained in tandem. A laser with a suitable wavelength will be used as the excitation source for both fluorescence and photocurrent. This imaging system will be validated by monitoring cell viability withfluorescence assay and photocurrent imaging, and by monitoring the cellular uptake of model NPs to correlate the physicochemical properties of NPs to their uptake efficiency and toxicity. These validation experiments will be compared with established techniques. This system will be used to study neuron-NP interactions to reveal the mechanism of NPs’ functional effects in neuronal activities. The combined imaging system will help us gain a deeper understanding of NP-cell interactions and will offer a label-free method for assessing the toxicity of NPs in the biomedicine field. Therefore, this project will facilitate the rapid development of safe and effective nanomedicines and nano-delivery systems that allow site-specific, target-oriented delivery of precise medicines to treat and prevent various diseases. This will significantly increase the impact of nanome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European left-wing populism and sovereignty: a comparative analysis of the national-popular discourses of the Belgian (PTB), French (LFI), Northern Irish (Sinn Féin) and Spanish (Podemos) cases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Scholars have long mainly associated the concept of populism – and its corollaries, such as sovereignty – with radical right political parties. However, in Europe, since the 2010s, the rise and electoral breakthroughs of the radical left have been based on populist elements, i.e. on rhetoric (1) opposing the people to the elite, and (2) demanding a radicalisation of democracy through the concept of popular sovereignty. Most scholars retain a minimal definition of populism based on three elements (people- centrism, anti-elitism, popular sovereignty) and therefore consider national sovereignty as a corollary of left-wing populist discourses. On the contrary, EuLeSov will consider national sovereignty as a constitutive element of (partisan) left-wing populism. The project focuses on internal party dynamics (membership and leadership) and aims to examine why and how the people the people-centrism and anti-elitism of European left-wing populist parties is built on the concept of popular sovereignty (plebs-people) but also on that of national sovereignty (nation-people). The project applies a mixed-methods research design to the comparative study of four political organizations (La France insoumise [Unbowed France, LFI], Parti du travail de Belgique [Workers’ Party of Belgium, PTB], Podemos [We Can] and Sinn Féin [Ourselves]) in four countries (France, Belgium, Spain and Northern Ireland). This empirical approach will provide a better understanding of the mutations that the radical left party family has known since the collapse of the Soviet Union. Examining the articulation between left-wing populism and national sovereignty is today crucial as some of these parties have succeeded in taking power and others are at the verge of power. Understanding their relationship to natio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'OFFshore GAs Separation'.

assistant: **Objectives**

Gas separations on offshore platforms are of increasing importance for the purification of natural gas and for the separation of CO2 used in enhanced oil recovery (EOR).Separations based on nanoporous materials, adsorption and membranes will be the method of choice for applications on floating platforms, where liquid solvents cannot be used due to problems arising from the tilting and rolling of the moving platforms.Developing effective materials and efficient process technologies for gas separations at high pressure plays a key role in the economic exploitation of offshore resources. Both Brazil and the EU have large vested interests in this field: Brazil has important offshore gas reservoirs situated where the seabed is too deep for a fixed platform, while EOR will be widely exploited in the North Sea.The proposed project will involve exchanges among three universities that are already conducting world-class research on materials and adsorption and membrane processes, thereby bringing together expertise on different aspects of the gas separation technology.The exchange of researchers will reinforce the links already established between the EU and Brazil, leading to further collaboration and joint proposals. In particular, the synergy between the research groups in the three institutions will give rise to technological breakthroughs that will also have applications in other fields.The project includes exchange of both early stage and experienced researchers to exploit fully the knowledge transfer for a total of 120 person-months exchanges. 23 experienced researchers will be seconded to a different institution. Early career researchers will spend a longer period of time in the partner institution in order to broaden their research knowledge and to experience a different