RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Resilient and Sustainable Software Security', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In parallel with the ongoing digitization, computer security has become an increasingly important and urgent challenge. In particular, the sound and robust implementation of complex software systems is still not well understood in practice, as evidenced by the steady stream of successful attacks observed in the wild. The current state of the art in software security consists of solutions that are often technically sound, but do not provide operational security in practice.     With the Resilient and Sustainable Software Security (RS³) project, we propose a compelling research agenda to fundamentally change this situation by developing novel countermeasures at different system levels that fundamentally improve security. On the one hand, the system must be ""resilient"" against entire classes of attack vectors. On the other hand, the system must be ""sustainable"", i.e., it must be able to maintain its security at least over its design lifetime and possibly even adapt over time. Our work plan addresses the problem from four different angles by(i) developing novel software testing strategies that enable accurate and efficient vulnerability discovery,(ii) designing secure compiler chains that embed security properties during the compilation phase that can be enforced at runtime,(iii) devising robust mechanisms that mitigate and patch advanced attacks, and(iv) investigating how hardware changes for open-source hardware (e.g., RISC-V processors) can improve the efficiency and accuracy of all of these goals.We expect to develop innovative methods and fundamental principles to build, test, and patch complex systems securely and efficiently. This holistic approach covers multiple layers of the computing stack, and each aspect has the potential to improve security significantly.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Evaluation of alternative techniques for determination of water budjet components in water-limited, heterogeneous land-use systems (WATERUSE)' (WATERUSE), addressing dissemination and exploitation.

assistant: **Impact**

We intend to provide tools for obtaining critical hydiological information on water balance of heterogeneous vegetation in low rainfall regions of Europe. The project aims to(i) develop high-resolution geophysical and physiological (e.g. sap-flow) techniques for the study of water in soils, roots and trees;(ii) evaluate methods for studying evapotranspiration at a single tree scale and for scaling up to communities and catchments, including the use of satellite remote-sensing;(iii) use large-scale multi-user field experiments to compare the techniques(iv) develop models for integrating these results for hydrological purposes. The 1st phase involves laboratory and field characterisation of novel techniques as well as the theoretical and experimental development of hardware and software. The 2nd phase is the intercomparison of the various techniques, in case studies in Portugal and Italy (emphasis on the scaling up of tree-scale to plots and catchments). The final phase will be the development of integrative models providing, in a user-friendly manner, critical hydrological information for managers and policy-makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quality Assurance and Development of an early warning system for microbial contaminations for the European Fruit Juice Industry' (QUALIJUICE).

assistant: **Concept**

European Small and Medium (SME) fruit juice producers face the problem of contamination of their products by lactate fermenting bacteria, provoking undesired fermentation processes and causing enormous financial losses for the afflicted companies. Responsible for these contaminations are an insufficient raw material quality (influenced by storage and climatic conditions), constructional deficits or insufficiently trained technical personnel. By the proposed collective research project the necessary tools to overcome these problems will be disposed to the community of European juice producing companies and other food producing companies facing this situation.The primary objective of QUALI-JUICE is to develop and validate an efficiently sensitive early warning system, which indicates a critical undesired bacterial spoilage during fruit juice production. The methodology will be applicable to all European juice producers for detection of microbial contamination with lactate producing bacteria. An early detection of beginning fermentation processes is beneficiary in several ways: Firstly, it helps to identify critical points in fruit processing. Hence, a substantial basis is given for decision-making towards repeated preservation measures (pasteurisation) in order to keep the juice suitable for human consumption. Thus, potential for saving raw material and production costs can be explored, increasing the productivity.The proposing associations will embed the early warning system technology in an overall training strategy for SME juice producers in order to provide an integrated approach for this specific industrial branch: The training strategy will therefore enfold also basic -resource management (logistics/raw material), -Good Manufacturing Practice, -tracing sources of mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'OPEN MUSIC EUROPE (OPENMUSE) – AN OPEN, SCALABLE DATA-TO-POLICY PIPELINE FOR EUROPEAN MUSIC ECOSYSTEMS' in the context of a Horizon Europe call.

assistant: **Objectives**

OpenMusE brings together music industry stakeholders and researchers from 11 EU countries and Ukraine. Our consortium recognises that placing European music ecosystems on a more competitive, fair, and sustainable footing requires evidence-based policymaking, business planning, and accuracy. We provide the data needed for these actions. Using transparent methods and tools, OpenMusE maps the policy and data landscape; bridges data gaps; and empowers stakeholders and policymakers to take data-driven actions. Our project is grounded on principles of open policy analysis, open science, and open-source software development. We work with stakeholders to identify data gaps on the EU, national, and regional levels; co-create indicators and methods for bridging them; develop free software tools for data collection and analysis; and report not just our findings, but every step taken to reach them. This is the logic behind our Open Music Observatory (OMO), an open-source platform that provides 360-degree intelligence on the music industry by integrating numerous data sources. The OMO is highly automated, providing “living policy documents” that refresh when the backend datasets are updated: these datasets include official statistics on music goods and services; data on musical participation via pan-European surveys, rights-holder data voluntarily shared by industry partners, and streaming service data sampled using novel algorithms developed by our consortium. Using the OMO and our open-source software, music MSMEs without technical departments or expertise will be able to access and analyse open data; model volume and value, including of zero-price uses; create better business models; and generate corporate social responsibility and sustainability reports; all at a fraction of cur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cyber Physical System based Proactive Collaborative Maintenance' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The overall concept of MANTIS is to provide a proactive maintenance service platform architecture based on Cyber Physical Systems that allows to estimate future performance, to predict and prevent imminent failures and to schedule proactive maintenance. Maintenance is no longer a necessary evil that costs what it costs, but an important function that creates additional value in the business process as well as new business models with a stronger service orientation. Physical systems (e.g. industrial machines, vehicles, renewable energy assets) and the environment they operate in, are monitored continuously by a broad and diverse range of intelligent sensors, resulting in massive amounts of data that characterise the usage history, operational condition, location, movement and other physical properties of those systems. These systems form part of a larger network of heterogeneous and collaborative systems (e.g. vehicle fleets or photovoltaic and windmill parks) connected via robust communication mechanisms able to operate in challenging environments. MANTIS consists of distributed processing chains that efficiently transform raw data into knowledge while minimising the need for bandwidth. Sophisticated distributed sensing and decision making functions are performed at different levels in a collaborative way, ranging from local nodes to locally optimise performance, bandwidth and maintenance; to cloud-based platforms that integrate information from diverse systems and execute distributed processing and analytics algorithms for global decision making. The research addressed in MANTIS will contribute to companies' assets availability, competitiveness, growth and sustainability. Use cases will be the testing ground for the innovative functionalities of the proactive maintenan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Measurement and Analysis of Generator bearing Loads and Efficiency with Validation' to be submitted under Horizon 2020.

assistant: **Abstract**

The project (MAGLEV) objective is to make a significant contribution to the new class of bearing relief generators. This contribution will be developed by building a demonstrator machine. Technical methods will be developed to reduce misalignments and vibrations of the generator, enabling operation at higher power density and efficiency compared to the existing solutions. MAGLEV will develop cutting edge IP, which could change the world of electrical machines completely if successful, and should be able to secure and enhance EU industries’ competiveness.MAGLEV includes challenging tasks such as measuring shaft instantaneous position and bearing loadings accurately in dynamic operating conditions at high speed, developing a control technology to emulate the loads on the generator with a bearing relief system, the commissioning of the demonstrator machine, obtaining test data, and validating the simulation results with test data.Close and efficient communication with the Topic Leader is one of the key success factors in MAGLEV.


**Keywords:** Generator efficiency & reliability improvement, Power density improvement through higher speeds and electrical frequency, Permanent magnet solutions with active rectifiers, Improve control technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'European Database for Multiscale Modelling of Radiation Damage'.

assistant: **Innovation**

ENTENTE ""European Database for Multiscale Modelling of Radiation Damage"" aims to design a new European experimental/modelling materials database to collect and store pedigree data on radiation damage of RPV steels, according to FAIR (Findability, Accessibility, Interoperability, and Reusability) principles. The project can be seen as three interconnected blocks:  DATABASE Design - Multi-disciplinary teams (materials scientists, engineers, software developers) for the definition of new effective data formats suitable for microstructural and modelling data, and interfaces needed to ensure interoperability.  - Interface the SOTERIA platform with the ENTENTE database so that experimental data and metadata could be retrieved and post processed in order to correctly parametrize modelling tools  ADVANCED experiments/models - Microstructural characterization, linked with appropriate models, by means of advanced (S)TEM techniques, APT, -XRD and in-situ TEM for mapping the radiation induced defects and associated strain-stress fields - In-depth analysis of segregation and structural, chemical nature and strength of grain boundaries to study hardening and non-hardening embrittlement INNOVATIVE data analysis and hybrid models - Simulation tools that enable the description of radiation damage up to space and time scales that are comparable with those reached in experiments on RPV steels. Accelerated physically informed fracture laws with a reasonable predicting capability on heterogeneous microstructures.  - First application of ICME (Integrated Computational Materials Engineering) approaches to enable virtual studies of alternative neutron embrittlement scenarios -Machine learning and artificial neural networks approaches to support atomistic modeling as well as to predict harden
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Therapeutic immunotherapy targeting NG2 and CD22 antigens for MLL-rearranged and MLL-germline B-cell Acute Lymphoblastic Leukemia' to be submitted under Horizon 2020.

assistant: **Abstract**

B-ALL is the commonest cancer of childhood. There remain childhood B-ALL subgroups with dismal prognosis such as infant B-ALL and B-ALL carrying MLL rearrangements (MLLr). In addition, the prognosis of adult B-ALL is worse, and refractory/relapse (R/R) B-ALL remains dismal. CD19-targeted immunotherapies have emerged as promising therapeutic approaches for R/R B-ALL. CD19 CAR T-cells have shown impressive efficacy in R/R B-ALL. However, relatively rapid relapses are frequently observed, a proportion of them losing CD19 expression upon CAR19 T-cell therapy due to massive antigen pressure over CD19, resulting in a myeloid lineage switch in MLLr B-ALL, or the selection of CD19-/CD34+ preleukemic progenitors. Further CD19-targeted therapy is thus ineffectual for CD19neg R/R B-ALL. Our overarching goal is to provide novel therapeutic options for (R/R) B-ALL.Targeting surface antigens whose expression, opposite to CD19, are commonly retained at relapse is a valid strategy to circumvent the loss of CD19 found in (R/R) B-ALL after CD19-targeted therapies. Recent work funded by my ERC-2014-CoG has identified NG2 and CD22 as key antigens to be targeted in (R/R) B-ALL. First, both antigens are retained in CD19neg R/R B-ALL. Second, NG2 is solely expressed in MLLr B-ALL, and is associated with CNS infiltration, aggressiveness and glucocorticoid resistance. Third, CD22 is a pan-B marker expressed developmentally earlier than CD19, and CD34+CD22+CD19- cells may represent pre-malignant progenitors escaping the CD19-targeted pressure. These results have just been protected by a European Patent (EPI173825514), and are the proof-of-principle demonstration of NG2 & CD22 representing promising immunotherapeutic targets, when combined with CD19 for both MLLr & MLL-germline B-ALL, respectivel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Targeting intracellular proteins and protein-protein interactions with site-specific lipobodies: a new approach for intracellular antibodies'.

assistant: **Concept**

The RAS family of GTPases is associated with important signalling events responsible for cell growth, proliferation and survival. Mutated RAS are, nevertheless, associated with uncontrolled cell proliferation in 30% of human cancers. Intracellular antibodies targeting oncogenic RAS proteins constitute promising anticancer therapeutics. Nevertheless, their intrinsic cytosolic instability as well as the lack of methods enabling their proper cellular uptake and localization highly limit their use and further development. This proposal describes the multicomponent synthesis of lipidic scaffolds (lipo-TAGs) for the permanent or temporal site-selective lipidation of anti-RAS antibody fragments. Lipidic antibodies (lipobodies) are novel constructs that could share the properties of any lipid-drug conjugate which includes oral bioavailability, enhanced lymphatic/tumour targeting and reduced toxicity. This project also aims to build amphiphilic lipobodies with the ability to experiment cellular uptake and endosomal escape, thus avoiding lysosomal degradation, and eventually experimenting cytosolic processing to generate the active antibody fragment. These unique features will be relevant not only at targeting RAS but any other intracellular protein or protein-protein interaction targets.


**Keywords:** RAS proteins, anti-RAS antibodies, multicomponent reactions, site selective bioconjugation, lipobodies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Early Mesozoic Biodiversity and Climate Change: marine ecosystem response to global warming and carbon dioxide rise'.

assistant: **Innovation**

The early Mesozoic (Permian/Triassic boundary to mid-Jurassic) was a critical time in the evolution of life on Earth, and understanding this interval of time is central to understanding the subsequent evolution of the marine biosphere. The earliest Triassic was a time of significant global warming and records the immediate aftermath of the most severe biodiversity loss of the Phanerozoic. The subsequent recovery, as climate ameliorated through the Triassic, was curtailed by another major extinction event in the latest Triassic, associated with an increase in atmospheric carbon dioxide levels, global warming and possible ocean acidification. Recovery in the earliest Jurassic was more rapid than that of the Early Triassic, but was affected by another episode of global warming and oceanic anoxia in the Toarcian. This project aims to understand the responses of the marine ecosystem to these past episodes of major global warming, including analyses of global, regional and local biodiversity loss and recovery. A key aim of this project will be the isotopic analysis of brachiopod shell material to provide the first quantitative palaeotemperature curve of the early Mesozoic. This will be combined with the morphometric and biodiversity analyses to assess how episodes of major global warming directly affect marine invertebrate groups. Ecosystem-level changes associated with global warming and anoxia will be evaluated. These data are to crucial to the evalaution of predicted ecosystem response to present day global warming and marine hypoxia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Real time nano CHAracterization reLatEd techNloGiEeS' in the context of a Horizon 2020 call.

assistant: **Objectives**

A cost-efficient production of reliable, innovative materials and devices like advanced electronics products (<65 nm strained channel transistors, CMOS image sensors) requires nanoscale real-time in-line control, nowadays not available, during manufacturing. State-of-the-art techniques capable to map physical observables at the nanoscale compatible with in-line operations, like Raman, InfraRed (IR), Photoluminescence (PL) spectroscopy, do not have typically enough resolution for the detailed characterization of nano-scaled devices. Signal amplification by localized plasmon resonance at a sharp tip can give the opportunity of improving both the spatial resolution and the signal/noise ratio. CHALLENGES main objective is to develop multipurpose nano-optical techniques and metrological protocols for real-time characterization, using plasmonic enhanced Raman, IR and PL signals, capable to enable an increase of speed, sensitivity, spectral range with full cleanroom compatibility within different production environments, to improve devices performance, quality and reliability. CHALLENGES will focus on development and demonstration of such technology on three relevant application contexts: Semiconductor Industry, Si Photovoltaics and 2D Materials. Overall, the envisaged results are expected to be applicable to many other industrial fields in which the materials control at the nanoscale is required, spanning from those others electronics-related (DRAM, non-volatile memory, MEMS) to those one materials science (additive manufacturing, nanocoatings) and life sciences (implants, softmatter apps) related. CHALLENGES is coordinated by a large silicon foundry company and it is strongly driven by industrial and applicative needs. The Consortium includes renowned EU research labs with t