RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unraveling the therapeutic potential of cancer-associated fibroblasts (CAF) in cancer using cell-specific targeting technology' (CAF), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is a major health burden affecting 12-million people each year world-wide. Tumor growth is not only determined by tumor cell malignancy but also by the tumor microenvironment. Cancer-associated fibroblasts (CAF) are key cell type in the tumor microenvironment influencing tumor initiation, angiogenesis, metastasis and tumor drug response. CAF strongly express platelet-derived growth factor receptors (PDGFR). The applicant has recently developed a novel drug delivery technology to target CAF using a PDGFR-binding carrier (HPC) which is composed of a PDGFR-binding cyclic peptide conjugated to albumin. Targeting of doxorubicin using HPC induced anticancer effects by depleting tumor stromal tissue in-vivo.This proposal aims to further exploit this technology to investigate the therapeutic potential of CAF in tumor. In the first part of the project, we will study the impact of CAF on tumor initiation, metastasis and tumor drug uptake. To carry out this, we will use doxo-HPC in order to kill CAF selectively in tumors and examine the effect on latter parameters. Of note, these experiments will be performed in the state-of-the-art genetically-modified tumor models specifically developed to study these tumor mechanisms.In the second part, we will study the relative importance of different signaling pathways (PDGF, TGF-beta and hedgehog) in CAF. Different inhibitors of these pathways will be conjugated to HPC. Treatment with these conjugates will induce blockade of these pathways in CAF through which we can study their importance in CAF-inducing effects. This project thus brings together the expertise of the applicant in targeted drug delivery with the experimental therapy expertise of the host group. Surely, this project will help the researcher in long-term integration an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Services in Innovation, Innovation in Services' to be submitted under Fourth Framework.

assistant: **Abstract**

The study Services in Innovation, Innovation in Services" aims to develop concepts, empirical evidence, and proposals for practical action concerning the role of services in European innovation systems. The study will determine the factors which shape services' roles, how these factors are themselves changing, and what role policies and business practices have in creating favourable contexts for services innovation.This project will be organised around "innovation in services" and "services innovation", as two aspects that consider the two roles of service activities towards innovation dynamics, as a site of or significant user of innovations, or as a "catalyst" of innovation processes, in networks with other economic sectors. The project will: - Map, understand and analyse the changing role of services and service innovations as users, carriers, shapers and services of innovation in European innovation systems, and - design, formulate and integrate options for innovation and technology policies and business strategies that take into account the role of services in innovation and innovation in services. The project will be organised in seven work packages of which six contain substantial research tasks. The work package on synthesis and policy options is to give implications for national and European innovation policies, business strategies, future research, and future development of innovation data gathering procedures and indicators. User involvement is foreseen through the partners' contact with policy makers and business community so as to strengthen the potential for dissemination of results at the end of the project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A smart hyperspectral system for early, non-invasive diagnosis of retinal disease' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The future of retinal diagnostics relies on data-backed smart devices that can see beyond the human eye. With a rising incidence of eye-related diseases further aggravated by the diabetes pandemic, early diagnosis and treatment could prevent up to 98% of sight loss resulting from diabetes. Advances in retinal imaging are in fact fundamental to our understanding and treatment of ocular diseases. XpectralTEK is a European startup focused on the development of imaging diagnostics that aim to improve the visualisation of objects, nature and the human body. By leveraging our expertise in spectroscopy, imaging and computer vision we developed a new hyperspectral fundus camera, XpeFundus. Our camera is capable to perform in-vivo retinal spectroscopy without excessive irradiation making the extreme light intensities and invasive diagnostic methods completely redundant and radically improving the patient experience. Through 3x improved visual mapping of eye tissue alterations, the doctor makes an earlier diagnosis of retinal pathology which leads to earlier prognosis and treatment. Backed by an AI-powered visualisation software and VR, our camera is a complete diagnostic tool that empowers ophthalmologists towards the rapid and non-invasive clinical evaluation of retinal diseases but can also prove a valuable tool for laser treatment, future doctor education and medical research.With the Global Fundus Cameras Market poised to reach a value of $743.3 million by 2025, we are confident that XpeFundus is coming to the market at the right time. Due to the increasing prevalence of eye disorders but also the stagnated number of new ophthalmologists entering the field, advances in retinal diagnostics are a global market high priority. We have already successfully commercialised our pate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sub Sea Quieter, a disruptive, low cost and highly efficient Noise Mitigation System for reducing MRE installation noise and turbidity impacts on underwater ecosystems' under Horizon Europe.

assistant: **Concept**

For offshore windfarms or coastal foundations, pile driving technique is often used. But it generates a high level of noise, which severly damages - up to death - marine mammals, fishes and other species. Noise Mitigation Systems (NMS) exist but with limits : high price, weak acoustic efficiency, bad behavior with current, waves and depth...To fill these gaps, we develop an innovative and eco-designed NMS : the SSQ® Pile Driving.It is based on the disruptive membrane Sub Sea Quieter® (inflatable panels of 3D-woven fabric, coated and sealed to insure acoustic efficiency) resulting from 5 years of R&D.Designed like a sock deployed closest and around the pile thanks to a clever manutention system, it aims at becoming the NMS technical reference by its very high acoustic mitigation efficiency, turbidity containment, its cost up to 5 to 10 times cheaper than existing NMS, with no any extra vessel or crane and its adaptability to the most severe site conditions (waves, curent, depth...).


**Keywords:** Marine Renewable Energy,Noise mitigation system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Intimate partner violence disrupts the brain-heart axis in women.' (PINK), addressing dissemination and exploitation.

assistant: **Impact**

The WHO defines Intimate Partner Violence (IPV) as any behavior within an intimate relationship that causes physical, psychological, or sexual harm to those in that relationship. IPV claims millions of victims worldwide, and women are by far most deeply affected. IPV poses unique challenges: it often goes undetected outside of the family unit and remains hard to treat due to its complex interpersonal nature. This evidence calls for better prevention, early screening, and interventions. Deepening our grasp of the deep wounds inflicted by IPV to the woman's heart and brain would help in achieving these unmet milestones. Multiple threads knit together estrogens and brain-derived neurotrophic factor (BDNF), a neurotrophin that, via the TrkB receptor, governs brain and heart well-being. Estrogen replacement increases BDNF expression in brain regions of ovariectomized mice, and the deletion of bdnf in the forebrain induces anxiety/depression in female mice. Here, I will test whether perpetuated IPV alters estrogen levels in premenopausal subjects, impairing BDNF/TrkB signaling, triggering cerebral/cardiac dysfunction, and interrupting the information flow between heart and brain. To test that, and the benefits eventually afforded by selective TrkB stimulation, or social enrichment (that boosts BDNF in the hippocampus), I built a mouse model of IPV morphed from the resident-intruder test: a highly aggressive male and a socially-defeated female. Strengthened by a cadre of collaborators expert in Neuroscience, Endocrinology, Cardiology, and Epidemiology, I seek to shed a mechanistic light on the brain/cardiac “wounds” inflicted by IPV on women, proposing some unprecedented remedies to prevent the transition from early alterations to overt heart, or brain disorders, or both. A be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Health and Environment-wide Associations based on Large population Surveys' (HEALS).

assistant: **Concept**

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools that support efficiently exposome studies. The general objective of HEALS is the refinement of an integrated methodology and the application of the corresponding analytical and computational tools for performing environment-wide association studies in support of EU-wide environment and health assessments. The exposome represents the totality of exposures from conception onwards, simultaneously identifying, characterizing and quantifying the exogenous and endogenous exposures and modifiable risk factors that predispose to and predict diseases throughout a person’s life span. The HEALS approach brings together and organizes environmental, socio-economic, exposure, biomarker and health effect data; in addition, it includes all the procedures and computational sequences necessary for applying advanced bioinformatics coupling thus effective data mining, biological and exposure modeling so as to ensure that environmental exposure-health associations are studied comprehensively. The overall approach will be verified and refined in a series of population studies across Europe including twin cohorts, tackling different levels of environmental exposure, age windows of exposure, and socio-economic and genetic variability. The HEALS approach will be applied in a pilot environment and health examination survey of children including singletons and sets of twins with matched singletons (each tw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Direct solar steam', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

PROJECT OBJECTIVES The objective of the DISS project is the development of a new generation of solar thermal power plants with improved parabolic trough collectors and direct steam generation (DSG) in the absorber tubes, thus eliminating the oil acting as a heat transfer medium between the solar field and the conventional power block. At present, more than 350 MW peak power are produced by solar thermal power plants with parabolic trough collectors. Nevertheless, the levelized electricity cost (LEC) of these solar plants is still too high to compete with fossil fuels. Project DISS is aims to increase the efficiency and reduce the cost of solar thermal power plants with parabolic trough collectors. TECHNICAL APPROACH The State-of-the-Art of solar thermal power plants using parabolic trough collectors is given by the nine SEGS plants in operation in California. Although increases to the efficiency of these plants has reduced costs from 24 c/kWh to roughly 9 c/kWh under Californian conditions, the levelized electricity cost (LEC) of these plants is still too high. Preliminary simulation results have shown that there exist some improvements that could reduce the LEC by 30%. The technical approach of DISS to develop these improvements is based on the following tasks: -Design and implementation of a real-scale test facility to investigate the open questions concerning the two-phase flow in the absorber pipes of solar parabolic trough collectors in order to eliminate the synthetic oil used in the SEGS plants. -Applied research on direct steam generation to investigate thermohydraulic aspects of the two phase flow in parabolic trough collectors -Study and evaluation of potential improvements for parabolic trough collectors to reduce the cost and to increase the efficiency EXPEC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CONTINUOUS ALUMINIZING OF STEEL TUBES, PROFILES OR RODS' to be submitted under Fourth Framework.

assistant: **Abstract**

An innovative continuous galvanisation technology of steel long products will be transfer to a aluminising process. The main feature is the use of magneto hydrodynamic forces to create seals of the liquid metal reactor and to control coating thickness. A demonstration line for aluminizing of steel flat tubes, used for air cooled condensers, (energy sector) will be designed and tested. Competitiveness of produced flat tubes, wires and rods will be analysed for applications in new industry sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced and sustainable recycling processes and value chains for plastic-based multi-materials' under Horizon 2020.

assistant: **Concept**

Plastics bring unprecedented value in terms of convenience, versatility of design and lightweight to European consumers as well as increasingly advanced performances even in high end applications. But only 31% of plastic packaging are currently recycled due to infra-developed technologies or to their unsatisfactory economic viability. This is in fact aggravated by considering plastics as commodity where their economic value is linked to a single use, often not taking into account the potentially generated end of life hurdles. In line with the just released Plastic Strategy for Europe, the time has come to stop the depletion, landfilling and incineration and shift to a Circular Model in the plastic sector improving the recycling rate but also the value of secondary raw materials from plastic recycling. As such, with an overarching mission to maximise the valorisation of our finite plastic resources, based on the CreaSolv® process (CreaSolv® is a registered trademark of CreaCycle GmbH) patented by the partner FRAUNHOFER, which will be upscaled and digitased, MultiCycle will deliver an industrial recycling pilot plant for thermoplastic-based multi-materials. This is a solvent based selective extraction process which allows recovering pure plastics in mixed wastes but also fibres without downgrading. The later compounding of recovered materials will also be optimised in terms of process and formulation. Our economically and environmentally sustainable MultiCycle process will be demonstrated in 2 main large volume sectors (as providers of waste to recycle and end users of the recycled materials):-Multilayer packaging but also flexible films that cannot be recycled cost effectively to date and altogether account for around 50% of plastic packaging, i.e. ca. 10 millions tons/y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'EURO-MEDITERRANEAN Cooperation through ERANET joint activities and beyond'.

assistant: **Objectives**

The main aim of the project is to enhance Euro-Mediterranean co-ownership through innovation and competitive research in the societal challenges of the region. The project aims at reducing fragmentation of programming in the Mediterranean region by increasing coordination among national research programmes of European Member States, Associated Countries and Mediterranean Partner Countries.Following the Conference of Barcelona on 2012, the ERANETMED responds to the need to develop new ways of “sustainable” cooperation, in which both European and MPC partners will equally participate and benefit from the output and the opportunities created by the project. The ERANETMED will consider a broad area for research, addressing not only the most important societal challenges of the region but also actions to enhance innovation through applied research, capacity building, mobility and clustering. Its action will result in concrete co-operation between research programmes, such as networking, definition of strategic scientific activities, research structuring for long-lasting and stable cooperation beyond ERANET.The main goals addressed by the project will be: -) establishing a framework for communication and coordination of programme owners and managers related to S&T cooperation from Europe and Mediterranean Partner Countries; -) strengthening Euro-Mediterranean R&I Cooperation promoting joint activities; -) developing joint funding schemes and procedures between partners; -) supporting long-term and stable Euro-Mediterranean cooperation; -) strengthen MPC capacities to enhance research and innovation and increase the impact of research on the socio-economic development of the region. It also implies the achievement of coherence among research, policy and funding instruments to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The use of electroheat technology (radio frequency and infrared energy) for the manufacture of casks in Europe' in the context of a Fourth Framework call.

assistant: **Objectives**

European cooperages are mainly S.M.E.'s located in rural areas and with relatively high production costs. This proposal aims to apply Electr technology to the production of the wooden casks which they make; the potential turnover could reach 76M ECU per annum. In cask manufacture an essential step is the heating of the internal surface(toasting); in Europe this relies upon open fires and has remained largely unchanged for hundreds of years. The procedure gives variable results and is expensive in terms of the time taken (> 45 minutes per unit). The Electroheat technique is highly consistent and can reduce this time by 90%. It is particularly suited to SME scale operations and also creates a clean working environment. European oak barrels are approximately double the cost of their Arnerican counterparts and presently over 80% of the 1.35 million barrels made each year are produced in the USA As economies of scale continue to increase and technological advances are implemented more American oak is likely to be used and the European share will become difficult to sustain. The largest stock of barrels in the World is in Scotland (ca 18 million) and are used for Scotch whisky maturation. Whilst this industry has a need for ex-sherry casks from Spain some 97% of their casks presently come from the USA. Imports from Spain have fallen by 400% in just over a decade. Electroheat technology with essential innovations in barrel processing could enable the production of wine and brandy casks which give oaky flavours (New World style), traditional European style casks i.e. producing well-developed value-added wines and Sherry casks used by Whisky distillers. The last mentioned would be at significantly reduced cost and would be produced in days rather than the present process which t