RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'On-chip topological demodulator for 6G THz wireless communications' (TopoChipTHz) under Horizon Europe.

assistant: **Objectives**

Recent advancements in terahertz (THz) technology have unlocked the po-tential for ultra-high-speed wireless communication, with data rates far sur-passing those of current 5G systems. Operating in the 300-600 GHz range, future 6G systems could enable wireless transmission rates of up to 1000 gi-gabits-per-second, revolutionizing applications like metropolitan networks and uncompressed video transfer. However, current THz technologies face challenges, especially in demodulating high-frequency signals. Existing la-boratory solutions rely on bulky, expensive electronics with limited band-width, high noise, and non-linearity, hindering the scalability of THz com-munication.In this project, we propose developing an on-chip topological coherent de-modulator for THz signals using topological photonic crystals, which ex-hibit robust, low-backscattering wave propagation. Leveraging the valley Hall effect in photonic crystals, the device will feature waveguides, beamsplitters, mixers, and balanced detection outputs, integrated on a silicon chip. This all-optical architecture offers a significant improvement over tra-ditional electronics-based systems, with a target demodulation bandwidth over 50 GHz for signals at 300 GHz.The proposed solution will address key bottlenecks in current THz technolo-gy, including size, bandwidth, and signal-to-noise ratio. As one of the first functional on-chip demodulators for THz frequencies, this device sets a new standard for future applications. Its compact design, scalability, and en-hanced performance position it as a key enabler for 6G wireless systems, driving ultra-fast data transfer for real-world use cases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'eDIGIREGION : Realising The Digital Agenda Through Transnational Cooperation Between Regions'.

assistant: **Objectives**

eDIGIREGION is a unique collaborative project that brings together a balanced blend of complimentary and experienced partners from four diverse regions. The sixteen (16) people involved in formulating this proposal are senior executives and decision makers in their respective organisations. These partners have embarked upon, are committed to, and have already demonstrated the power of transnational collaboration and cooperation by jointly conceptualising and articulating eDIGIREGION’s vision, and preparing this proposal.The ultimate aim of eDIGIREGION is to enhance regions’ sustainable competitiveness by exploiting their strengths and smart specialisations to realise the Digital Agenda within a regional domain. This will be achieved by increasing the interoperability between the triple helix of regional actors (government, research centres and universities, and industry) to define and action region specific Joint Action Plans (JAPs). Through a planned process of inter and intra-regional mentoring, the eDIGIREGION project will also facilitate transnational and international collaboration leading to the creation of an inter-regional Joint Action Plan (iJAP). As well as increasing transnational collaboration, cooperation, knowledge and technology transfer, and the sharing of resources, the JAPs will align regional RTD, innovation, and economic policies, strategies and practices.A unique aspect of this project is the live testing of the JAPs by facilitating regional actors (researchers, SMEs, government agencies and funding agencies) to bring technology through the innovation process.The lasting legacy of the eDIGIREGION project is an electronic central repository, accessible to all regional stakeholders across the EU, that will contain all the methodologies, techniques and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identifying biomarkers of Exposure leading to Lung Cancer with Adductomics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Over 20% of death by cancer in the world are due to Lung Cancer (LC).  Tobacco, and recently, exposure to air pollution, are considered the main causes for LC, thus specific carcinogens have been only partially identified. The complex composition of tobacco smoke and air pollution makes it difficult to identify the specific compounds responsible for the carcinogenesis process. To understand the mechanisms of LC onset, methods are needed to characterize specific toxicants that people are exposed to. We propose to develop a new method to identify exposure-specific (tobacco or air pollution) markers of LC. This new method is based on the measure of the ensemble of electrophile-carcinogens and human serum albumin adducts in human serum:  the Adductome. Electrophiles present in blood are highly reactive species that have been long suspected of causing cancer because of their ability to bind DNA and proteins. Protein adducts provide more suitable markers of exposure as they have a longer life span in the blood and are present in much higher concentrations, but have been poorly investigated. In EXACT we hypothesise that protein-carcinogen electrophiles adducts can be used as markers of LC carcinogenesis and that different markers can be identified for tobacco-induced or air pollution-induced disease. Our objective is to improve the current analytical methodology for adductomics analysis and develop a new methodology for adducts structural identification in order to characterize adduct profiles in 400 samples of human serum from the EPIC cohort. Statistical analyses will be carried out to link adducts profiles to smoking status, air pollution data and methylation profiles. The elucidation of the markers structure will allow us to establish a database of candidate compounds resp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a new hybrid jet-spindle spinning system for clean, flexible and competitive high quality yarns production' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The most original and innovative part in the adopted solution resides in the high effectiveness of twist of the nozzle that offers the spinning system developed to produce yarn with a very similar structure to the conventional yarn, but produced to high-speed regime up to 600 m/min. As a prove of the originality and degree of innovation of the proposal is, that at the moment, it is assured the rights of property through the corresponding patent application. For a machine of pneumatic spinning, the key part is in the effectiveness of twist of the nozzle to produce a yarn the most similar as possible to the conventional yarn.This is the part that has been developed with more success in the project, as is mentioned before, very high production speeds have been reached between the order 400 and 600 m/min. This advance so spectacular of the production, that surpass the foreseen expectations of the project.In the figure it is shown inside the space formed by the following coordinate: quality, title of the yarn and productivity, where it is located the different spinning industrial systems at the moment in exploitation compared with the pneumatic wrapped spinning system with real torsion. It can be observed as the pneumatic wrapping spinning system with real wrapped torsion, developed during the project occupies the market space reserved to the yarns elaborated under conditions of high productivity, obtaining a level of quality comparable to conventional yarns. To this market space it belongs the around 50% of the spun ones below 30 tex, elaborated to world level, with an economic volume of around 530 millions EUR/year for the UE economic area and 1.200 millions EUR/year for Europe. These facts contribute to that the installation of a new spinning system starts with extremely
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Singleton trajectories. Understanding new life course paths of young adults.' (SINGLETON), addressing dissemination and exploitation.

assistant: **Impact**

The intellectual challenge that the Singleton project will tackle is identifying the relationship formation pathways of young adults in industrialized countries. This project departs from the currently couple centred research approach of young adulthood in which developmental pathways always seem to lead to Mount Marriage or Cohabitation Hill. In contrast, we argue that there is a fundamental hidden relationship pathway in young adulthood where individuals might be experiencing difficulties in finding the right partner, maintaining a relationship or where they make a deliberate choice to remain single and for longer periods. This Singleton trajectory is characterized by a sequence of relatively short-lived committed relationships. The central question addressed in the Singleton project is therefore why, how, when and for whom this relationship trajectory manifests itself. Accordingly the project has four interrelated aims. A first aim is the empirical description of the share of Singletons in three birth cohorts. Second, the project will look at the internal dynamics of relationship formation, maintenance and dissolution from a multi-actor perspective to identify differences between young adults. In the third objective, the project will look into how social networks, educational trajectories and career prospects influence the development of relationship trajectories in young adulthood. A final aim will look at the macro level and incorporate the rise of a single culture as part of a new explanatory framework for understanding the Singleton trajectory. Methodologically, we apply a Longitudinal Explanatory Mixed Methods model (2 quantitative and 2 qualitative waves) concentrating on 3 cohorts in young adulthood. This project innovates on a theoretical and methodological l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced Simulation of Aircraft Mechanisms' (ASAM).

assistant: **Concept**

This is a proposal for a research project that aims to fulfill the objectives as set up in the Call SP1-JTI-CS-2013-01-GRA-02-023. Therefore is will investigate advanced design and simulation methods for Load control and alleviation devices and high lift devices. The research will focus on novel methods for modelling of aerodynamic loads on flexible bodies, modelling of actuators and methods for coupled simulation. The novel methods will be evaluated in context of preliminary and detailed design studies of 4 mechanisms as specified in the call:1. Krueger Flap (GTF)2. Single Slotted Flap (GTF)3. LC&A devices4. Single Slotted Flap (TP)NOVOTECH will be responsible for the preliminary design studies and knowledge transfer. LMS will be responsible for the detailed conceptual designs and management of the project.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EcoSpace: Spatial-Dynamic Modelling of Adaptation Options to Climate Change at the Ecosystem Scale' (ECOSPACE) under Seventh Framework.

assistant: **Objectives**

Climate change will necessitate adjustments in ecosystem management in order to maintain the functioning of ecosystems and the supply of ecosystem services. The aim of this project is to develop a spatially explicit, dynamic modelling approach for identifying and analysing adaptation strategies for ecosystem management.In particular, the project will develop and apply a general, spatial model integrating climate change scenarios, ecosystem dynamics, response thresholds, ecosystem services supply and management options. The scientific innovation of the project lies in the application of an ecosystem services approach to analyse adaptation options, the integration of complex ecosystem dynamics and societal impacts, and the spatially explicit modelling of economic benefits supplied by ecosystems.The general model will be tested and validated on the basis of three case studies, focussing on: (i) flood protection in the Netherlands; (ii) impacts of climate change in northern Norway; and (iii) optimising land use including production of biofuels stock in Kalimantan, Indonesia. The first two areas are particularly vulnerable to climate change, and the third area is relevant because of its importance as a source of biofuel (palmoil) with associated environmental and social impacts. Each case study will be implemented in collaboration with local and international partners, and will result in the identification of economic efficient, sustainable and equitable local adaptation options.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular analysis of the Hedgehog signal transduction complex in the primary cilium' (CilDyn), addressing dissemination and exploitation.

assistant: **Impact**

The unexpected connection between the primary cilium and cell-to-cell signalling is one of the most exciting discoveries in cell and developmental biology in the last decade. In particular, the Hedgehog (Hh) pathway relies on the primary cilium to fulfil its fundamental functions in orchestrating vertebrate development. This microtubule-based antenna, up to 5 µm long, protrudes from the plasma membrane of almost every human cell and is the essential compartment for the entire Hh signalling cascade. All its molecular components, from the most upstream transmembrane Hh receptor down to the ultimate transcription factors, are dynamically localised and enriched in the primary cilium. The aim of this proposal, which combines structural biology and live cell imaging, is to understand the function and signalling consequences of the multivalent interactions between Hh signal transducer proteins as well as their spatial and temporal regulation in the primary cilium. The key questions my laboratory will address are: What are the rules for assembly of Hh signal transduction complexes? How dynamic are these complexes in size and organisation? How are these processes linked to the transport and accumulation in the primary cilium?I will combine state-of-the art structural biology techniques (with an emphasis on X-ray crystallography) to study the molecular architecture of binary and higher-order Hh signal transduction complexes and live cell fluorescence microscopy (for protein localisation and direct protein interactions). These two approaches will allow me to identify and define specific protein-protein interfaces at the atomic level and test their functional consequences in the cell in real time. My goal is to consolidate a world-class morphogen signal transduction laboratory, dec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Non-Markovian Memory-Based Modelling of Near- and Far-From-Equilibrium Dynamical Systems' (NoMaMemo) targeting Horizon 2020.

assistant: **Abstract**

Time series characterize diverse systems, examples in this proposal are: i) Proton motion in an inhomogeneous aqueous environment, ii) folding and unfolding of a peptide described by a suitably chosen reaction coordinate, iii) migration of a living cell on a substrate, iv) US Dollar / Yen exchange rate. Examples i) and ii) are close-to-equilibrium, iii) is a far from equilibrium since energy is constantly dissipated, while example iv) at first sight defies the classification into equilibrium or non-equilibrium.For the understanding, comparison, classification and forecasting of time series data, stochastic differential equations, diverse random walk models, and more recently, machine-learning algorithms are commonly used. But fundamental questions remain unanswered: Is a unified description of such diverse systems possible? What is the relation between different proposed models? Can the non-equilibrium degree of a time series be estimated? NoMaMemo provides a unified description of generic time series data in terms of non-linear integro-differential stochastic equations based on memory functions that are extracted from data. NoMaMemo accounts for non-linear and non-equilibrium effects as well as for non-Gaussian noise and connects with fundamental concepts such as equilibrium statistical mechanics, response theory and entropy production. The general formulation contains previously proposed models and thus allows their comparison, forecasting quality will be compared with modern machine-learning algorithms. NoMaMemo creates a generic platform to analyse, understand, compare, classify and predict time series data and to optimize stochastic systems with respect to search efficiency, barrier-crossing speed or other figures of merit. NoMaMemo will significantly advance the u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Representation spaces of three-dimensional manifolds' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The purpose of my research project is to investigate the connection between the topology and geometry of 3-dimensional manifolds and the algebraic and analytic properties of their representation spaces. The main part of the project deals with the exploration of the link between analytic and algebraic-topological methods. The gauge theory plays a central role in my project because it provides the connection between topology and analysis. My objective is to find an algebraic and topological interpretation of invariants of 3-dimensional rnanifolds which are defined via gauge theory (e.g. Chern-Simons invariant and Floer homology). More precisely, two key goals are, firstly to find an extension of Casson's invariant for 3-dimensional manifolds with boundary and secondly to give an algebraic-topological interpretation of the Jones polynomial are other aims of my project. Besides this principal project my host Michel Boileau (Pr University), Joan Poni (CR CNRS) and myself plan to engage on a common research project. The aim of the common project is to prove Thurston's orbifold conjecture at worst in some special cases. Training content (objective, benefit and expected impact) The training will enable me to present my Habilitation" at the Universitat-Gesamthochschule-Siegen. Therefore, I expect the training should have a strong positive impact on the prospects of my career. I am sure I will benefit from the daily contact with the specialists already working in Toulouse. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '3D Genome structure and function', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Results will give new and important insight into how the eukaryotic genome in general, and the human genome in particular, operate inside the living cell. This program will lay the groundwork for understanding how, beyond the regulation at the individual gene level, large-scale chromatin structure affects the complex gene regulation networks in normal and deceased cells. Understanding molecular mechanisms that underlie regulation of this large set of genes is a key target in modern medical sciences and biotechnology. Our knowledge about gene regulation at the single gene and the epigenetic level is rapidly expanding.However, our understanding of the role in gene control of the three-dimensional folding of the genome in the cell nucleus, is still poorly understood; this despite the fact that considerable evidence is available showing that large-scale chromatin organization plays an important role in gene control in higher eukaryotes. 3DGENOME has the ambition to force a breakthrough in our understanding of the relationship between the function of the genome and its dynamic 3D structure in the cell. To this end we will analyse the 3D structure of the human genome in the cell nucleus and relate this to its transcriptional activity. Structural analysis is carried out by fluorescent in situ hybridization (FISH) in combination with advanced 3D light microscopy. Large-scale chromatin structure of four selected chromosomes (11, 17, 18 and X) will be determined in three different cell types, differing in gene expression. Gene activity along the chromosomal fibre will be read from the human transcriptome map and correlated with structure. Work on human cells will be expanded to mouse and Drosophila,aiming at establishing causal and evolutionary conserved relationships between 3D