RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Using clonal sampling to analyse oesophageal epithelial homeostasis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Stem cells are generally thought to maintain homeostasis in adult tissues, producing committed progenitor cells that in turn generate terminal differentiated cells. Although adult stem cells have been studied intensively, far less is known about how they function in vivo to maintain tissue homeostasis. It has long been assumed that adult tissues are maintained by long lived, slow cycling, self renewing stem cells which generate a population of committed progenitors known as “transit amplifying” (TA) cells. TA cells undergo several rounds of proliferation, after which they terminally differentiate. This widely accepted model has been called into question by a recent study of the epidermis, which shows that the normal tissue is maintained by a single type of progenitor cell capable of both asymmetric and symmetric cell division, stem cells being quiescent under normal conditions. It is unclear whether this single compartment model will apply to other tissues as well as the epidermis. In this project we will study how tissue homeostasis is achieved in another stratified squamous epithelium, that of the oesophagus. By defining the behaviour of a representative sample of progenitor cells, we will be able to determine whether their behaviour conforms to the predictions of the stem and TA cell hypothesis or an alternative model. Since many of the pathways that control normal stem cell fate have been associated to tumour development, advances in the knowledge of the oesophageal homeostasis will establish the basis for further research in the study of the molecular alterations that lead to cancer development in this little studied but important tissue, which is a common cause of human disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Alternative materials in road construction' (ALT-MAT) under Fourth Framework.

assistant: **Objectives**

The main objective is to define methods by which the suitability of alternative materials for use in road construction can be evaluated. Within this ultimate objective, there are a number of particular objectives:(1) develop methods for simulated field tests;(2) determine mechanisms and rates of release of contaminants from alternative materials in road construction;(3) establish standard laboratory leaching tests for alternative materials;(4) determine appropriate mechanical and hydrodynamic tests for alternative materials;(5) prepare a specification for full scale trial embankments;(6) compare potential pollution with that from other sources; and(7) consider mitigation measures where possible. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Direct Investigation of a Folding Energy Landscape and Its Implications for the Unexplained Folding Behaviour of Spectrin Domains' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Spectrin domains R15, R16 and R17 are found in tandem arrays in proteins of the cytoskeleton, and spectrin itself is believed to be responsible for maintaining the shape of erythrocites by imparting elasticity to the cell membrane. These three domains share virtually identical structure, stability, contact order, helical propensity, and transition state structure. However, in spite of the striking structural resemblance and the apparently common function, these proteins fold to their native conformation with a speed that varies over more than three orders of magnitude. Why? There is some evidence to suggest that such diversity originates from energy landscape “roughness”. Slow folding domains (R16 and R17) appear to have rough energy landscapes, whereas the fast folding domain R15 has a smooth energy landscape. By means of a novel, single-molecule spectroscopic technique developed by Prof. Benjamin Schuler at the Department of Biochemistry of the University of Zurich, I want to test this hypothesis, investigating directly the energy landscape of these homologous spectrin domains, quantifying the roughness of their energy landscape, and discover its sequence determinants. This research is the first direct investigation of energy landscape roughness of proteins for which this feature is believed to clearly affect the folding rate. These studies could not only result in substantial conceptual progress in the field of protein folding, providing a missing link between theory and experiment, but also lead to further developments of the single-molecule spectroscopy for biophysical investigation in general
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Centre of excellence in environmental chemistry and ecotoxicology' in the context of a Fifth Framework call.

assistant: **Objectives**

The proposed Centre of Excellence for Environmental Chemistry and Ecotoxicology RECETOX (Research Centre for Environmental Chemistry and EcoTOXicology), Masaryk university, Brno, Czech Republic is oriented at the field of environmental chemistry, ecotoxicology and risk assessment. The long-term environmental research projects are aimed at understanding the fate of selected organic pollutants in the environment and the study of relationships between environmental contamination by these pollutants and their biological effects. Based on this research and educational activities, the European and regional scientific network will be organised and as a part of network activities the exchange of staff and students will be arranged and thematic conferences and workshops will be prepared. Particular attention will be paid to regional scientific studies focused on persistent, toxic substances.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design and synthesis of glycosidase-stable ganglioside mimics as cholera toxin ligands' to be submitted under Sixth Framework.

assistant: **Abstract**

Specific binding between bacterial enterotoxins and oligosaccharides on the host cell membrane is a paradigm for protein-sugar interaction. One of the best-characterized recognition pairs is formed by ganglioside GM1 and the cholera toxin (CT).Synthetically accessible ganglioside mimics that act as high-affinity ligands for CT may lead to drugs capable to block the interaction between the toxin and target cells, thus preventing the onset of the disease. Much synthetic effort has been devoted to the synthesis of gangliosides, but the development of ganglioside mimics is still surprisingly little explored.The major part of the reports come from the host laboratory which has reported a group of pseudo-oligosaccharides, rationally designed to mimic the 3D structure of GM1. Some of these molecules display high affinity for CT and are structurally much simpler than the natural ligand, but their rather complex synthesis and expected instability towards glycosidases make them poor candidates for potential medicinal applications.The present project is aimed to the design and synthesis of glycosidase stable mimics of the GM1 ganglioside as efficient and selective CT inhibitors. As a general strategy, the two-pharmacophoric fragments of GM1, a sialic acid and a galactose residue, will be connected to each other through a linker using non-glycosidic bonds.The linkers' design will be based on the known X-ray structure of the CT: GM1 complex. Optimization of the linker will be obtained either through parallel synthesis or using a target-guided approach. This project is connected to the activities of the COST D34/001/05 WG, working on cholera toxin inhibition and sensing.This fellowship and the framework provided by the COST group will ensure the opportunity for the pro poser to be ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a multilayered and bioprinted iPSC-derived retinal model with use in preclinical and toxicological testing' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Age-related macular degeneration (AMD) encompass the most prevalent cause of vision-loss in elderly people in developed countries. One of the main hurdles restraining the development of efficient treatments against AMD is the inability of current animal, 2D-cellular and organoid-based models to completely recapitulate the pathophysiology of this disease. The goal of the iRETINA project is to bioprint an in-vitro human retinal model using isolated endothelial and retinal cells derived from iPSCs. The result will be a functional and vascularized iPSC-derived tissue resembling the native stratified retina that could serve as a preclinical and toxicological model for drug development and for the study of complex phenomena such as allogenic immune response. In order to achieve this goal, the iRETINA project will focus at three different levels: 1) implementing state-of-the-art genome editing tools for the development of retinal cell differentiation and enrichment strategies from healthy and AMD-patient iPSC; 2) developing new methodologies for bioprinting endothelial and retinal cells aiming to preserve cell viability, synaptic connectivity and structural integrity; 3) proof of concept testing to evaluate the usefulness of the artificial retina as a bona fide in vitro retinal model. The nature of this project is strongly multidisciplinary and involves the collaboration of basic researchers with experts in the fields of ophthalmology, immunology and biomaterial sciences. The results of this proposal have the potential to represent a true technological and scientific breakthrough that will result in better organ and disease modeling, and reduced laboratory animal use, eventually minimizing the burden and complexity of preclinical trials required for the development of novel ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of expanded slate for horticultural and aggregate use' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Greaves, the lead proposer, have carried out trials using a small pilot furnace which has demonstrated that a lightweight aggregate can be produced from the thermal expansion of slate waste. There is a wide commercial market for the product throughout Europe in both the horticultural and building block manufacturing markets if it can be produced at an economic cost. Further research is necessary to minimise production costs and to develop the application for specific products. The research programme will be divided into five work packages - development of a thermally efficient furnace - characterisation of the physical and chemical properties of the new material - characterisation of the horticultural capabilities of the new material - development of advanced building blocks and roofing tiles using the new material - investigation of use of the new material in rehabilitating slate quarry waste tips The slate industry is characterised by the large quantities of waste which it produces. The pilot research has shown that slate waste from different deposits reacts differently to the heating process. It is therefore an important part of the research programme to establish that the technology developed has wide application to meet these differing characteristics of deposits across Europe. The Partners represent interests in each aspect of the research programme. Two are long established slate producing companies who handle large quantities of waste material. Their key interest is to find an economic use for that waste instead of causing a large disposal cost to their industry. If the project is successful they will create many new jobs in rural areas of high unemployment and safeguard their futures. Two partners have horticultural interests based in slate producing areas in n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Numerical simulation and analysis of climate variability on decadal and centennial time scales' (MILLENIA).

assistant: **Innovation**

To improve the understanding of natural climate variability on timescales of decades and centuries, and to prepare a multi-millenia numerical experiment with an improved fully coupled ocean-atmosphere-ice model. The output from the 1250 year MPI climate simulation will be examined in order to identify and eventually  understand the internal mechanisms of the climate system which are responsible for the formation of low  frequency anomalies. An better degree of realism of the model data will be established by comparing with  observed and analysed data.  This analysis will include the utilisation of dynamical theory and a number of statistical techniques, such as  EOFs, POPs and multichannel singular spectrum analysis, in order to identify principal modal structures and  their dynamics. Additional numerical experiments with Ocean and atmosphere GCMs will be used to study  particular aspects of the atmosphere ocean couplings.  The low frequency variability created in the 1250 year experiment will be compared with proxy data from tree  rings and ice cores and to historical atmospheric and oceanic data. Nonlinear analysis techniques will be used  to describe the attractor, principal weather regimes and principal clusters in the modelled climate system. The  models systematic errors on time scales of large anomalies will be diagnosed; special emphasis will be placed  on the variability relating to sea-ice, the maintenance of recurrent anomalies and teleconnection patterns.  For the preparation of a future multi-millenia numerical experiment the dynamical, diagnostic, numerical and  logistic requirements of a coupled ocean-atmosphere model to allow for realistic simulations of climate  variability on time scales of decades to centuries. A number of specific issues will be inve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modelling crisis management for improved action and preparedness' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The CRISMA project shall develop a simulation-based decision support system (Integrated Crisis Management System - ICMS), for modelling crisis management, improved action and preparedness. The ICMS shall facilitate simulation and modelling of realistic crisis scenarios, possible response actions, and the impacts of crisis depending on both the external factors driving the crisis development and the various actions of the crisis management team.A common set of criteria and performance indicators for crisis management simulation and optimisation provided by CRISMA modelling system shall enable decision makers and crisis managers to: (1) model possible multi-sectoral crisis scenarios and assess the consequences of an incident, (2) simulate possible impacts resulting from alternative actions, (3) support strategic decisions on capabilities, related investments, reserves, inventories (3) optimise the deployment of resources dedicated to crisis response in-line with the evolvement of a crisis, and (4) to improve action plans for preparedness and response phases of the crisis management.Long term sustainability and uptake of the CRISMA results shall be assured through recommendations from decision makers and external high-level experts in the CRISMA advisory board, compatibility with ongoing developments in environmental usage area, and design for extensibility through new models, criteria and performance indicators.Key CRISMA value proposition is the higher security of the European citizens, through improved understanding of the crisis evolvement and the impact of various decisions and actions at disposal of the crisis management on that evolvement, as well as through provision of the IT-support for decision making and auditing of the decisions made during both real and simul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Formulation and characterization of new aluminium alloys produced by ingot metallurgy for high temperature applications (250ºC)'.

assistant: **Concept**

The main objective of the project is to develop a new aluminium wrought alloy that can work at temperatures in the range of 200-250ºC for aeronautical applications such as regulator valves or actuator bodies for air treatment systems. Several heat resistant aluminium based materials have already been developed in the last years that might be applied for such high temperature applications. Notwithstanding, these are either too expensive or present additional technical drawbacks such as insufficient ductility, segregation of components, low machinability or recycling problems.The present project aims at developing new alloys through a methodology based on the identification of the effect of up to 12 alloying elements and their combinations in the heat resistance of wrought alloys through the Taguchi methodology. This is based on the selection of critical parameters through design of experiment techniques that minimise the time and resources to be employed in the process. Two orthogonal matrices are to be used, a L16 matrix and a modified L8 matrix. The former employs two levels that are related to the maximum and minimum amounts of the alloying element. The modified matrix incorporates intermediate values. In a first stage gravity casting samples with 24 different formulations are cast by gravity casting and preliminarily tested in order to check whether any of these combinations may reach the established specifications Subsequently, the most promising 2 alloys would be further developed.Researchers belonging to the non ferrous metallic materials and characterization departments of Tecnalia will lead the project. Their work will be complemented by the researchers at Fundación Inatec, a research institution that is part of the Otua industrial group related to recycling and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A NOVEL SUSTAINABLE PAPER CUP FOR TAKE AWAY DRINKS' (UCUP) under Horizon 2020.

assistant: **Objectives**

Near 58 billion paper cups are used globally per year. This involves the consumption of one million tonnes of virgin paper, cutting down 32 million trees, the consumption of 100 billion litres of water, the generation of 25,000 tonnes of waste (solely in the UK), and the emission of greenhouses gases equivalent to half a million cars. Paper cups are often lined or coated with plastic such as polyethylene (PE) or oil- based waxes to prevent the liquid from leaking out or soaking through the paper. These paper cups are almost impossible to recycle because of the difficulties of separating the paper from waterproof oil-based liners. This means paper cups end up going to landfill or, at best, are incinerated to generate energy. The heavy environmental impact of paper cups is extremely unsustainable, with each one generating a carbon footprint of 0.11kg of CO2. UCUP, a novel sustainable paper cup for take-away drinks, provides an innovative solution to reduce the huge environmental impact of disposable cups. UCUP features an eco-innovative material obtained from brown seaweed which is bio-based, biodegradable and recyclable while it provides the same properties as current oil-based liners (waterproof, thermal and mechanical resistance) at a competitive price. Our main objective is to exploit the business opportunities of this new material in the food packaging and food services packaging (ready-to-eat & take away) sectors. We plan to launch UCUP onto the market and seek to further develop it to a market-ready product. We will use Phase 2 for this purpose, with a total investment of €2 million in 18 months. The overall plan is to market UCUP first in UK and speed up scalability at international level through a network of allies and partners. Thanks to this strategy, we expect