RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sensory and Biomechanical Markers in Diabetic Neuropathy of the Gut. Basic Investigations and New Approaches for Treatment' (DIAMARK).

assistant: **Innovation**

DIAMARK is focused on analysing the pathophysiology of diabetic neuropathy and to determine better biomarkers of the complications and approaches for intervention. Due to lack of standardisation, there are no accepted biomarkers to evaluate the neuropathy and its involvement in the GI tract. Diabetes mellitus (DM) is one of the most common endocrine disorders affecting almost 6% (app. 246 million people) worldwide (http://www.idf.org). DM is a chronic disease requiring lifelong attention in order to limit the development of potentially devastating complications and to manage them if they occur. Gastrointestinal (GI) disorders are common and closely associated with autonomic neuropathy. Several studies addressed the visceral sensory function in DM and demonstrated abnormalities in perception thresholds, vagal tone and evoked brain potentials in patients with autonomic neuropathy. Thus, DM-related changes may be located in the enteric, the peripheral and in the CNS.  Several clinical, neurophysiological and biochemical test for neuropathy have been proposed but they are not reliable and valid. This makes is crucial to develop better biomarkers for GI neuropathy and associated complications, to test the reliability and validity under controlled circumstances using advanced multimodal methods and to follow the biomarkers during new treatments. This proposal aims at determining new biomarkers related to the enteric nervous system (response to stimulation), peripheral nerves (recordings from visceral nerves) and central nervous system (evoked brain potentials and computation of the brain sources activated). After reliability testing under controlled circumstances in the laboratory and the clinic, the validity of the biomarkers will be followed during the most promising new tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transcriptional regulation of endothelial blood brain barrier differentiation by Wnt signaling', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The brain vasculature has evolved to protect the central nervous system from the constantly changing milieu in the blood stream. Endothelial cells of brain capillaries form the so called blood brain barrier (BBB), an active permeability barrier and transport system which allows a selective passage of nutrients from blood to the nervous tissue. The continuous cross talk of endothelial cells, pericytes and nervous cells influences many vascular functions and determines and maintains the BBB characteristics after birth. Our limited knowledge of the nature of these signals prevents effective therapy of several diseases such as hemorrhagic stroke or brain edema.  Furthermore, the development of tools to reversibly ¿open¿ the barrier would strongly improve drug delivery to the brain.In the present project we propose to tackle the problem by studying the transcriptional mechanisms which direct BBB differentiation. This strategy is based on preliminary work which shows that the cross talk between nervous cells and the endothelium is mediated by Wnt factors and downstream beta-catenin transcriptional activity. The understanding of the mechanism of action of Wnt signaling on brain endothelium may yield novel strategies and tools for modulating BBB permeability.The project is divided in three related objectives: 1) to define the mechanism of action and downstream partners of Wnt in brain angiogenesis and BBB differentiation; 2) to use this knowledge to develop an optimized BBB model in vitro and in vivo; 3) to test whether modulation of Wnt signaling may have a therapeutic impact in the regulation of BBB in pathological conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Palaeoenvironmental Investigation of Amazonian Lowland Sensitivity to Climatic Drivers Using Pollen-based Modelling Approaches' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Amazon is one of the world’s most biodiverse ecosystems and our greatest carbon-sink, but human activity and climate change are posing severe threats to its existence. We are still a long way away from knowing how sensitive plants in the Amazon really are to variations in temperature and precipitation. One way we can understand this is by looking at fossil pollen accumulated over thousands of years, which can be used to reconstruct what the forests looked like over time and how they changed. In the context of Amazonia, so far there hasn’t been a way to connect changes in the pollen assemblages with climatic events because the forests in this region are diverse and many areas respond differently to environmental factors, and there is not enough data to allow comparisons between sites. To understand the sensitivity of Amazonia to climate change, we aim to use pollen-based modelling to reconstruct changes in temperature, precipitation and seasonality in the lowlands of Ecuador and Peru. This will be achieved by collecting modern pollen samples and gathering other existing datasets from collaborators, as well as modern climate data recovered from meteorological stations. We will use these datasets to calibrate key existing fossil pollen records from the region thereby enabling the reconstruction of palaeoclimatic parameters through the use of ‘transfer functions’. By improving our database of modern pollen for the lowlands of Amazonia and applying novel modelling techniques, we aim to provide new knowledge about ecological tipping points, plant responses to abrupt changes, effects on population abundance and structure and lags in response to climate. This project represents a key advancement not only to the field of tropical palaeoecology, shedding light on the response
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular signatures as diagnostic and therapeutic targets for disseminated epithelial malignancies' (DISMAL), addressing dissemination and exploitation.

assistant: **Impact**

Disseminated tumour cells (DTC) occur at very low numbers and can be detected using sensitive immunostaining and PCR methods. However, sensitivity and in particular specificity of this approach need to be improved. Combining the expertise of 11 academic pa rtners with long-term expertise in micrometastasis research the DISCOUNT-project will establish an improved platform for DTC detection with an increased sensitivity and - in particular - with a largely improved specificity. Besides DTC detection also analy sis of circulating tumour DNA and RNA, and expression profiling of tumours are being explored for assessment of minimal disease. We will focus on epithelial tumours as the most common types of solid tumours in the EU, investigating the carcinoma types that display different modes of metastatic spread. Dissemination into regional lymph nodes will be analyzed as well as haematogeneous dissemination of DTC via the blood circulation, using bone marrow as an important indicator organ to which epithelial tumour c ells home. Using genomics-based approaches, novel diagnostic target molecules will be identified and validated in functional models. We will complement immunocytochemical DTC detection by additional genotypic and phenotypic markers relevant for metastatic progression. To further increase diagnostic precision we will analyze whether this improved platform can be combined with analysis of tumour characteristics that were revaled by the microarray analysis, and with evaluation of circulating tumour-associated DNA or RNA. Besides the focus on improvement of DTC-based diagnostic platforms, it is important to realize that these cells are the target cells for adjuvant chemotherapy and radiotherapy. In innovative DTC models, the efficacy of DTC treatment will there-fore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Effects of co-infections on the emergence of an avian disease Mycoplasma gallisepticum' (ECODIS).

assistant: **Concept**

The investigation of processes that trigger cross-species transmission (‘spillover’) is central to disease ecology and epidemiology. Many infectious diseases in humans and domestic animals have emerged from successful jumps from wildlife hosts. The interactions of coinfecting pathogens within the same host are considered to be important in these spillover processes. However, despite the relevance of coinfections, little is known about the copathogen dynamics in the wild. There is a need for general concepts and theories. “Ecodis” proposes to fill this gap by determining a conceptual framework for effects of copathogens on disease transmission in one of the world’s best studied parasite-songbird systems: the directly-transmitted Mycoplasma gallisepticum bacteria in House Finches. Using methods from disease ecology and human epidemiology, I (Dr. Heylen; the applying experienced researcher) combine experimental and field surveillance data to create models on cross-host infection risks. These innovative models will improve our understanding of the roles of coinfections in mediating pathogen establishment and persistence in novel host species and previously unexposed populations. I will be guided by high-profile scientists, Hens (Hasselt University) and Dobson (Princeton University), and benefit from their extensive networks to develop a set of crucial skills that boost my research profile and expertise in constructing/applying mathematical and theoretical models in disease ecology. Following the ‘One Health’ vision, this multidisciplinary and highly translational project will allow me to develop an international career as disease ecologist, and - in the long-term - to contribute to biodiversity and risk management programs in Europe and beyond.


**Keywords:** Disease model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Immunogenicity of Mesenchymal Stem Cells in vivo' (IMSCIV) targeting Seventh Framework.

assistant: **Abstract**

The immunogenicity of allogeneic mesenchymal stem cells (MSC) and their differentiated progeny in vivo under regular or inflammatory conditions will be addressed using established mouse models of allorecognition and spontaneous autoimmune diabetes. Survival and homing of MSC in vivo in syngeneic and allogeneic recipients will be investigated by tracking MSC. Allorecognition of mouse MSC in vivo will be assessed using CD8+ T cells from BM3 T cell receptor transgenic mice, which specifically recognise the MHC class I molecule H2Kb. The importance of antigen presenting cells (APC) and helper T cells in allorecognition of allogeneic MSC in vivo will also be examined. The non obese diabetic (NOD) mouse model will allow investigation of the immunogenicity of MSC in vivo in an inflammatory environment. The effect of IFN-gamma activation of MSC prior to in vivo transplantation into NOD mice will determine the role of this cytokine in the development of a hypo-immunogenic phenotype of MSC in vivo. The reparative and immunosuppressive ability of MSC, activated MSC and insulin producing islet-like differentiated MSC in autoimmune diabetes in vivo will be assessed using the NOD mouse.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Pathways between Children’s Behavior problems and Parental Stress and Parenting among Parents of Children with Autism Spectrum Disorders' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Children with Autism Spectrum Disorders (ASD) experience a complex range of social, emotional, and behavioural difficulties that present significant, ongoing concerns for parents. A well-accepted sequel of children's ASD is increased parenting stress. Despite consistent evidence demonstrating significant ongoing associations between behavioural difficulties among children with ASD and parenting stress, few studies have examined potential underlying processes that link children’s behaviour problems to parenting stress. Several longitudinal studies have demonstrated a bidirectional relationship between child behaviour problems and parenting stress and well-being. However, over and above the caregiving demands placed on parents of children with ASD, little is known about parenting behaviours of parents of children with ASD, let alone whether they are impacted by parenting stress. The first Study of the proposed project will examine the mediating role of mothers' cognitions regarding their parenting and mothers’ executive function abilities between child behaviour problems and parenting stress. The second will investigate the relations between parental stress, parenting negativity, and parent-child interaction among mothers of children with ASD in comparison to mothers of typically developing children. In addition, it will examine whether child behaviour problems moderate these relations; and the link between parenting stress and parental involvement among mothers of children with ASD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Smart multi Stimuli-responsive Supports for controlled cell growth' (THREE-S) under Seventh Framework.

assistant: **Objectives**

This project deals with the development of Smart multi Stimuli-responsive Supports for controlled cell growth. Multi-stimuli responsive materials have not been widely investigated because they require fine tuning of the chemistry and precise control over the response to multi-stimuli. We propose to combine the initiated Chemical Vapor Deposition (iCVD) to synthetize the materials and the use of x-ray based reflectivity techniques to control the response. iCVD can be used to obtain polymer thin film with high chemical groups specificity. Cells respond differently to substrates with different stiffnesses. One extremely innovative use of this material will be that a single substrate can be used to control the cell growth instead of different substrates with different stiffness. The response of temperature, humidity and light irradiation of a light-responsive hydrogel will be deeply investigated. The envisioned outcome will be that the water uptake of the hydrogel changes with the afore-mentioned stimuli, resulting in stiffness change. The structural changes in the film will be monitored by X-ray scattering and the water uptake changes by X-ray reflectivity (XRR) using humidity controlled cells and temperature-controlled stage. Nowadays XRR is considered the most precise tool for thin film characterization. The structural changes will be monitored before, during and after irradiation. iCVD was invented at the Massachusetts Institute of Technology (MIT), Boston and is very widespread in Europe. The fellow will transfer the knowledge acquired at MIT, on the iCVD process, to the Graz University of Technology (TUGraz). This will certainly help creating a long-term collaboration between MIT and TU Graz and will contribute to the development of excellence in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Digital solutions for improving the sustainability performance and FLEXibility potential of HYDROpower assets'.

assistant: **Objectives**

The European energy system is undergoing a significant transformation: decarbonization, security of supply, deployment of renewables and their integration into the market, generating significant opportunities and challenges for energy stakeholders. Despite all energy efficiency efforts, overall demand for decarbonized electricity is set to be significantly higher in 2050 than today due to the decarbonization of the heating, cooling, transport and many industrial sectors, which can only be achieved via efficient and smart electrification. Hydropower is a key technology in supporting the European pathway to a decarbonized energy system and to achieve global leadership in renewable energy generation. It consists a renewable and highly sustainable electricity resource and can supply the European power system with stability and valuable flexibility. In addition, hydropower reduces EU’s dependency on fossil imports and renders multiple extra benefits for society in the river basins such as support to irrigation, water supply and flood control. The D-HYDROFLEX project will advance excellence in research on digital technology for hydropower paving the way towards more efficient, more sustainable, and more competitive hydropower plants in modern power markets. D-HYDROFLEX will develop a toolkit for digitally ‘renovating’ the existing hydroelectric power plants based on sensors, digital twins, AI algorithms, hybridization modelling (power-to-hydrogen), cloud-edge computing and image processing. The core pillars of the project will be: (i) digitalization, (i.e., digital twins for hydro dams and machinery, weather and flow forecasts, cyber-resilience), (ii) flexibility, (i.e., coordination with hydrogen, storage and VPP operation) and (iii) sustainability, (i.e., biodiversity envir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sensing and Quantum Engineering with Magnetically Functionalized Ultracoherent Mechanical Resonators' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Strained nanomechanical resonators have record-high quality factors at room temperature and state-of-the-art thermal-limited force sensitivities. However, they are typically made of dielectric materials that do not interact strongly with neither sensing targets nor other quantum systems. I propose to functionalize ultracoherent mechanical resonators with a nanomagnet to unleash their potential both for nanoscale magnetic sensing and the creation of hybrid quantum systems. The force sensitivity of the best strained nanomechanical resonators allows sensing of single proton spins when functionalized with a nanomagnet, providing new ways to characterize quantum devices and to investigate the three-dimensional structure of complex molecules such as proteins. Direct coupling of mechanical resonators and a single two-level system is a challenging but attractive route to synthesis of arbitrary quantum motional states in mechanical resonators. The low frequency of strained nanomechanical resonators has made this type of interaction elusive, but recent progress makes it conceivable to coherently couple a single atom and mechanical motion by direct magnetic coupling. I will leverage optical tweezer technology to directly couple the internal quantum states of a single atom to the motion of an ultracoherent mechanical resonator and exploit this interaction to generate quantum states of motion.By combining integrated photonics with ultracoherent nanomechanical resonators, SEQUENCE will develop unprecedently sensitive on-chip force sensors that can be used for characterization of biomolecules and quantum devices. The hybrid atom-mechanical system will realize a new interaction between single quantum systems and mechanical resonators which can be used in tests of fundamental physics, q