RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of Arl13b in endocytic trafficking', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

To move cargo between specific membrane-bound intracellular compartments, eukaryotic cells have evolved numerous mechanisms of membrane trafficking regulation. We found that CD1a, an MHC Class I-like lipid antigen presenting molecule follows an endocytic recycling pathway similar to that used by MHC Class I and other cargo internalized independently of clathrin. In an attempt to discover new regulators of this pathway, we screened a shRNA library for changes in CD1a surface expression and we found that the small GTPase Arl13b could be involved in the regulation of endocytic trafficking. The knock-down of Arl13b caused the clustering of early endosomes and the accumulation in this organelle of recycling cargo, such as transferrin, and also cargo destined for late endosomes and lysosomes, such as dextran. Moreover, the recycling rate of CD1a was decreased when Arl13b was knocked-down. Together, these results indicate that Arl13b regulates a sorting step from the early/sorting endosome. Arl13b belongs to the Arf-like (Arl) family of small GTPases, which remains poorly characterized. By uncovering its function we will shed light on the regulatory functions of this family of proteins. Future studies will focus on finding Arl13b effectors, determining if Arl13b binds to the cytoskeleton like other Arls, and also establishing the role of this protein in the primary cilium, a structure where Arl13b localizes prominently.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The development of biologically active metal implants for improved osseointegration' in the context of a Seventh Framework call.

assistant: **Objectives**

Osteoarthritis (OA) is the most common musculoskeletal disorder and affects approximately 355 million people world-wide. At present, no definitive cure exists for OA. Current treatment involves total joint replacement (TJR) which accounts for approximately 35% of arthritis related procedures. Presently more than 200,000 total knee replacements and 70,000 total hip replacements procedure are performed annually in the UK. One of the key aspects contributing to successful fixation is the rapid and complete integration of the device with bone (osseointegration). Without this biological reaction, stability is compromised potentially resulting in aseptic loosening which generally requires revision surgery. This can be detrimental for OA patients as the quality of bone is compromised, therefore, the potential for adequate implant stabilisation is substantially reduced. Several studies have identified the surface properties of an implant as being a major determinant of osseointegration. The addition of coatings have attracted interest, however, a major stumbling block for reliable application of coating technologies is potential failure during long-term implantation. Recent data suggests that impaired peri-implant osseointegration is associated with declined osteoprogenitor recruitment. The scientific objective of this project is to identify a strategy for enhancing rapid osseointegration of implant devices through 1) increased recruitment and attachment and 2) modulation of mesenchymal stem cell (MSC) differentiation. To this end, we aim to develop specific cell targeting antibodies for optimal MSC recruitment and modulation of MSC differentiation for improved osteogenesis. If successful this project would achieve in providing a clinically feasible strategy for improving TJR w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unraveling the fundamentals of transport across the vapor-liquid interface' (InterLab).

assistant: **Concept**

Transport of energy and particles across vapor-liquid interfaces is central for growth of rain drops in the atmosphere, evaporation from lakes, distillation columns, development of micro/nano-fluidic devices and much more. The objective of InterLab is to develop theory and methods to reproduce evaporation rates from steady-state experiments with water and octane within an accuracy of 10%. Such a theory is needed urgently since the established alternatives overpredict evaporation rates of water by 2-3 orders of magnitude. The core component of this new theory is the local thermal conductivity in the interfacial region.To reach its objectives, InterLab must fill major knowledge gaps in the fundamental understanding of transport across vapor-liquid interfaces. The tensorial behavior of the local thermal conductivity at the interface will be described and the nature of the thermal insulation layer at the vapor-side of the vapor-liquid interface will be understood. Octane and water will be investigated to clarify the role of hydrocarbon chain contributions and hydrogen bonds. The predictions from the new theory will be tested against nonequilibrium molecular dynamics simulations and new evaporation experiments. To be able to distinguish the different transport mechanisms for evaporation and validate the theory, two experimental rigs will be built. The rigs will measure the pressure to an accuracy that is one order of magnitude better than what has been reported in the literature. A computational fluid dynamics model will be used to extract information about the local heat flux across the vapor-liquid interface to achieve sufficiently high accuracy. The overarching goal is to obtain an understanding, a theory, and quantitative agreement from the molecular level to lab-scale e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Individual Behaviour and Economic Performance: Methodological Challenges and Institutional Context' (IBEP), addressing dissemination and exploitation.

assistant: **Impact**

Individual Behaviour and Economic Performance: Methodological Challenges and Institutional Context is a project led by Tallinn University of Technology (TalTech, Estonia) in collaboration with internationally leading counterparts Aalto University (Finland), University of Helsinki (Finland) and Tel Aviv University (Israel). The project aims at networking between the partners for research capacity building at TalTech and achievement of lasting synergies in the consortium in the academically and societally promising area of generating a better understanding of linkages between individual behaviour and economic performance. Behavioural economics has deepened our understanding of various deviations from rationality in economic performance. Economic outcomes of prevalent individual differences in cognitive capacity and neurophysiology as well as in beliefs and preferences warrant further investigation. Moreover, better designed economic policy and institutions, which take into account that people are different and their wellbeing responds differently to any given policy measures, leads to better utilisation of human capital endowment and enhanced economic performance. The project is a joint effort of economics, finance, practical philosophy and neuroscience scholars, where several internationally highly renowned professors work under a comprehensive set of networking and capacity building activities together with established and early stage researchers in a stimulating multidisciplinary setting. The cohesive consortium provides a unique platform for achieving novelty and excellence in research and developing the research profile of TalTech and its team by integrating TalTech and the partners into a highly functional and unique interdisciplinary partnership. The value of the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Low-power spin-wave-based computing' under Horizon 2020.

assistant: **Concept**

Downscaling of Si-based microprocessors has considerably increased the amount of heating in computers and other information and communication technology (ICT) devices. As a result, computer servers in big data centres waste more than 90% of the electricity they pull off the grid. High-density electrical currents in microprocessors and interconnects cause excessive warm-up via an effect known as Joule heating. To fulfil future requirements for data transmission and processing rates with low energy consumption, a paradigm shift away from purely charge-based electronics is needed. Recently, post-Si computing with collective spin wave excitations in tailored magnets has been identified as a promising route. Spin waves are transmitted through a magnetic material without the displacement of electric charges (i.e. currents), thus drastically reducing energy consumption and heating. We recently demonstrated that short-wavelength spin waves can be emitted and manipulated by small voltage pulses in ferroelectric-ferromagnetic bilayers. In the ERC PoC project we will use our results to realise an industrially relevant integrated spin wave computing device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Control and Optimization of Energy Flow in Complex Molecular Networks' (COMPLEX).

assistant: **Concept**

The production of sustainable energy that generates a clear and net greenhouse gas saving is one of the main EU objectives. Nature provides with the most efficient energy infrastructures known today. A deeper understanding of photosynthetic systems, and how energy transfers within its different subunits would show us the way to efficient energy flow, opening the path to the fabrication of highly efficient solar cells and transmission networks.The aim of the COMPLEX project is to provide insight to the energy conversion and transfer in complex molecular systems. We will develop and identify methods used in quantum mechanics, statistics and quantum information theory to model the energy transport in complex networks. Optimisation methods from mathematics and engineering will be applied to analyse biolological and artificially fabricated systems. Findings will be transfered to other related systems such as nano-engineered networks of nanofibers and polymers, which are designed for efficient transport with applications in organic solar cells and light-emitting devices and to further complex systems.This breakthrough in the state-of-the-art in terms of understanding energy flow in complex networks will take place by applying and transferring the specialised knowledge of Dr. Mirta Rodriguez, a Physics Researcher back from a research career break and specialist in the field of complex quantum systems dynamics, through scientific leadership to the research team at ZIB, where the computational infrastructure and knowledge and will be available to the Fellow. Specialist knowledge in applied technologies and innovation management gained by the Felow during her career break from R&D in Physics, will ensure that the results attained within the COMPLEX project will not only remain as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SpaceInvader – Gain value from empty and unused cargo space' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

500 million EURO pallets are used in 4 billion cargo transports every year in Europe. The pallet infrastructure in central to European cargo as transporters can use and leave pallets with minimal transactions costs, as all parties involved use the same standard. This market standard is central to efficiency.The problemWhile the infrastructure is established and well-functioning, the efficiency is decreasing in recent years resulting in higher CO2 costs and inefficient marginal cost per pallet.The efficiency is decreasing as weight per pallet is decreasing; leaving unused weight & volume potential as most trucks can carry more weight & volume than what is currently loaded. The main issue is the lack of floor space, and that pallets are not easily stacked on top of each other, leaving unused volume in the top space of the truck.Our solution The solution is an extension of the present EURO pallet technology to accommodate the decrease in cargo weight. SpaceInvader ApS has developed a multilayers pallet stacking system, called the SpaceInvader. Combined with existing equipment, the SpaceInvader enable pallets to be stacked in two layers and thereby use the free top space capacity available in 80-90 % of all truck transportations. The potential value of the solution for transportation companies is very high, as the sector makes revenue and compete on very low marginal costs. By being able to fully optimize the load of their trucks, transportation companies become more competitive, and can reduce their carbon footprint by simply having to drive fewer times in order to deliver the same amount of goods. Based on initial input from large test customers (ASKO, SuperGros, Danske Fragtmænd), we have chosen a business model where a set of SpaceInvaders will be rented out for 65 € a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biodegradable MEMS implants for nerve repair' to be submitted under Horizon Europe.

assistant: **Abstract**

In this project, I will develop biodegradable MEMS (Micro-Electro-Mechanical Systems) implants for nerve repair, a new class of microsystems made entirely of biodegradable materials, including sensors, actuators, and electronics.These wireless implants will focus on the mechanical stretching of peripheral nerves in vivo for neural regeneration after injury. Two strategies will be explored, compared, and combined: 1) cyclic mechanical nerve stimulation with NerveCyclicStretch, a soft biodegradable magnetic implant controlled by wireless magnetic actuation with an integrated strain sensor, and 2) constant mechanical traction with NerveSuctionStretch, a biodegradable implant applying negative pressure to the injured nerve with a biodegradable MEMS micropump and with an integrated pressure sensor. New biodegradable stretchable magnetic and conducting materials will be developed for this purpose, and in vivo studies on the sciatic nerve of rat models will be performed to demonstrate the proper operation of the implants and to identify the optimal mechanical stimulation parameters for nerve repair.The development of new functional biodegradable materials (with tailored magnetic, electrical, and mechanical properties) and cleanroom-compatible fabrication processes (thin films deposition, photolithography, etching of biodegradable metals and polymer composites) will enable the realization of fully biodegradable microsystems while retaining the established advantages of MEMS (small size, high precision, fast response time, low energy consumption, reliable large-scale production).This proposal is a paradigm shift in the design of medical devices, with biodegradable implants allowing for the first time the in vivo exploration of a promising new therapeutic approach. Beyond neurosc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Demand Response Integration tEchnologies: unlocking the demand response potential in the distribution grid'.

assistant: **Concept**

Addressing call topic area 3 (DR Technologies), DRIvE links together cutting edge science in Multi-Agent Systems (MAS), forecasting and cyber security with emerging innovative SMEs making first market penetration in EU DR markets. In doing so, near market solutions are strengthened with lower TRL, higher risk functionalities that support a vision of an “internet of energy” and “collaborative energy network.” From the research side, MAS will move closer to real time operations and progress from a limited number of assets toward decentralized management of a larger number of assets providing DR services to prosumers, grid stakeholders and DSOs. The research will deliver a fully-integrated, interoperable and secure DR Management Platform for Aggregators with advanced hybrid forecasting, optimization, fast-response capabilities and enhanced user participation components in a standard-compliant (Open ADR) market-regulated (USEF) manner, empowering a true cost-effective mass-market (100's millions of heterogenous assets). The project features 5 pilots across 3 countries consisting of a stadium, wind farm, 7-floor office, tertiary & residential buildings within medium-large districts, resulting in over 25 MW of potential flexible capacity. Direct engagement of 100 households and 2 tertiary buildings (over 1,000 persons) is attained and replication to over 75,000 persons is possible. The pilots will be running in real DSO environment with real engagement of grid players. Overall, DRIvE will make available average 20% of load in residential and tertiary buildings for use in DR, resulting in up to 30% cost-saving (price-based DR) and also maximizing revenue for prosumers (incentive-based DR). DRIvE will also allow a minimum 25% increase of renewable hosting capacity (distribution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improved Frontal Impact Protection through a World Frontal Impact Dummy' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Frontal collisions produce the highest frequency is fatalities and injuries in road accidents, the costs to the European Society alone being more than 160 billion EUROs each year. Even though the European Frontal Directive became effective only recently, further research is required to better assess the protection offered to car occupants in frontal impacts. An important motive for this is found in the current Hybrid-III crash test dummy that has shown important deficiencies in human likeness and injury assessment capabilities. The general objective of this project is to contribute to reduction of the amount of injured and death car occupants in frontal collisions through the development of a frontal impact dummy prototype (FID) that meets currents day needs. This dummy will have realistic behaviour and injury indicating measurements, durability and repeatability, all based on the latest biomechanical and accidentological information collected or generated in the project.1) Identification of the principal occupant injuries in frontal impact car crashes and the injuries for which a legislative frontal dummy should have the capability to measure injury risk;2) New biomechanical data;3) Set of requirements for frontal impact dummies, consisting of at least biofidelity requirements for all important body parts, repeatability, durability and anthropometry requirements based on the most recent biomechanical data;4) Review and revise (where appropriate) injury assessment values for a legislative frontal impact dummy;5) A prototype instrumented frontal impact dummy (THOR-FT), 50th percentile male, fulfilling the requirements defined within the project and suitable for inclusion in the Frontal Directive as successor of the Hybrid-III dummy;6) A computer model of the THOR-alpha d