RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional analysis of human eye-expressed genes by heterologous expression in drosophila melanogaster: a model system' (1994-1998).

assistant: **Concept**

- To identify human (or mouse) eye-expressed genes from the EST database, using information on mammalian and Drosophila eye mutants, and from sequence of immuno-screened dipteran photoreceptor membrane proteins. Map and assess as disease candidate genes. - To isolate full length mammalian cDNA clones for selected ESTs, and clone into relevant Drosophila eye expression vectors. Create controlled over-expression Drosophila lines, and look for phenotype. - To pinpoint gene function through identifying interacting genes by genetic crossing of selected over-expression lines with deficiency stocks, to reveal modifier genes. - To identify and map mammalian homologues of modifier genes and assess as candidate disease genes.Three groups with primary interest and expertise in human genetics, particularly in relation to eye disease, propose to team up with three Drosophila genetics groups, with special expertise in the analysis of eye development and function. The plan is to develop a Drosophila model system, which can be used to explore the function of newly, identified human (and mouse) genes, which are expressed in the developing and/or adult eye. Full-length mammalian cDNAs will be isolated for ESTs, which have been shown by RNA in situ and RNA blot hybridisation to be expressed in the eye. The cDNAs will be cloned into Drosophila vectors constructed using promoters/enhancers with temporally and spatially defined eye expression patterns. These will include GAL4/UAS gene-trap vectors as well as other eye-specific expression constructs. Transgenic Drosophila transformants with controlled over-expression in the eye will be produced in the strong expectation that these will exhibit various ey phenotypes. The Drosophila transgenics will be crossed with specific mutants, deficiency
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microbial risk assessment of dental unit water systems (duws) in general dental practice (gdp)' (1998-2002).

assistant: **Innovation**

Little knowledge exists on cross-infection risks from dental unit water systems (DUWS) in general dental practices (GDP), with no guidelines for their safe maintenance. We propose to determine quantitatively microbial contamination odes in GDP in Europe; the role of biofilms in DUWS contamination will also be assessed. The presence of pathogens (Legion Ella, Mycobacterium and hepatitis Antigen) in DUWS will be determined. We will develop a laboratory DUWS system, to determine the efficacy of current and novel control regimes under controlled, reproducible conditions. Disinfectant regimes developed in the laboratory will be assessed in site in GDPs. The project will provide evidence-based guidelines for permissible numbers of microbes in DUWS water, and recommend practical, safe and effective microbial contamination control measures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart system of renewable energy storage based on INtegrated EVs and bAtteries to empower mobile, Distributed and centralised Energy storage in the distribution grid' under Horizon 2020.

assistant: **Concept**

An inspiration for INVADE are the world-wide agreements on minimisation of human caused effects to climate change and energy efficiency targets set at the European Union with ambitious goals for reduction of greenhouse gas emission and for increase of renewable energy share. To enable a higher share of renewable energy sources to the smart grid and gain a traction in the market place a few critical barriers must be overcome. There is a deficiency of 1) flexibility and battery management systems 2) exploration of ICT solutions based on active end user participation 3) efficient integration of energy storage and transport sector (EVs), 4) novel business models supporting an increasing number of different actors in the grid. INVADE addresses these challenges by proposing to deliver a Cloud based flexibility management system integrated with EVs and batteries empowering energy storage at mobile, distributed and centralised levels to increase renewables share in the smart distribution grid. The project integrates different components: flexibility management system, energy storage technologies, electric vehicles and novel business models. It underpins these components with advanced ICT cloud based technologies to deliver the INVADE platform. The project will integrate the platform with existing infrastructure and systems at pilot sites in Bulgaria, Germany, Spain, Norway and the Netherlands and validate it through mobile, distributed and centralised use cases in the distribution grid in large scale demonstrations. Novel business models and extensive exploitation activities will be able to tread the fine line between maximizing profits for a full chain of stakeholders and optimizing social welfare while contributing to the standardization and regulation policies for the Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Tunable optoelectronic devices by strain engineering of 2D semiconductors'.

assistant: **Innovation**

The goal of 2D-TOPSENSE is to exploit the remarkable stretchability of two-dimensional semiconductors to fabricate optoelectronic devices where strain is used as an external knob to tune their properties.While bulk semiconductors tend to break under strains larger than 1.5%, 2D semiconductors (such as MoS2) can withstand deformations of up to 10-20% before rupture. This large breaking strength promises a great potential of 2D semiconductors as ‘straintronic’ materials, whose properties can be adjusted by applying a deformation to their lattice. In fact, recent theoretical works predicted an interesting physical phenomenon: a tensile strain-induced semiconductor-to-metal transition in 2D semiconductors. By tensioning single-layer MoS2 from 0% up to 10%, its electronic band structure is expected to undergo a continuous transition from a wide direct band-gap of 1.8 eV to a metallic behavior. This unprecedented large strain-tunability will undoubtedly have a strong impact in a wide range of optoelectronic applications such as photodetectors whose cut-off wavelength is tuned by varying the applied strain or atomically thin light modulators. To date, experimental works on strain engineering have been mostly focused on fundamental studies, demonstrating part of the potential of 2D semiconductors in straintronics, but they have failed to exploit strain engineering to add extra functionalities to optoelectronic devices. In 2D-TOPSENSE I will go beyond the state of the art in straintronics by designing and fabricating optoelectronic devices whose properties and performance can be tuned by means of applying strain. 2D-TOPSENSE will focus on photodetectors with a tunable bandwidth and detectivity, light emitting devices whose emission wavelength can be adjusted, light modulators ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cease or Persist: A multivariate mechanistic account of effortful persistence' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Is this worth my effort? Should I persist and push through or give up and move on? We are constantly confronted with this fundamental question. Persisting through effortful endeavors at all costs is often the key to success in modern society. Reduced or excessive persistence is a hallmark dysfunction in many neuropsychiatric disorders (anxiety, depression, OCD, apathy, etc.) with massive individual and societal cost. Despite the urgency to better understand this process, how exactly we decide to cease or persist, and which cognitive, neural and neurochemical systems support persistence, remains unclear. With COPE, I propose a novel neuro-computational theory of effortful persistence, able to predict decisions to Cease or Persist (COPE), and how they emerge from the dynamic multivariate optimization of costs and benefits across momentary and long-term time scales. I propose that persistence depends on how much reward or punishment we expect, how effective our efforts are, and how surprising and unstable the environment is. I will 1) establish and test a neuro-computational model able to simulate effortful persistence, and the neural and neurochemical systems involved in supporting it. 2) I will causally test the neural circuit involved in effortful persistence combining transcranial Focused Ultrasound stimulation with advanced neuroimaging protocols designed to capture activity in small brainstem and midbrain nuclei. 3) I will probe the contribution of 3 key neurochemicals – Dopamine, Noradrenaline, and Serotonin – and use the COPE model as a prediction tool of the impact of pharmacological manipulation on brain systems and behaviour. COPE integrates the algorithmic, neural and neurochemical levels of explanation in a unifying model of effortful persistence, laying the g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding the Nature of Exotic Hadrons - Charmonium Spectroscopy at BESIII' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The field of charmonium spectroscopy is one of the most exciting areas of research in particle physics. In the past years a whole series of mysterious discoveries were made. These totally unexpected states are called XYZ particles as the quark content of these states might be exotic. An exotic hadron is classified as a bound object of quarks with a quark content different from the well known meson (consisting of a quark and an anti-quark) or baryon (consisting of three quarks) states. XYZ particles are indeed candidates for exotic hadrons.The situation has dramatically changed with the discovery of the Zc(3900) particle at the BESIII experiment in China. The fact that the Zc(3900) particle has an electric charge different from zero is a clear proof of its exotic nature. This discovery, together with a series of additional findings in the recent past, proofs that BESIII is the world leading facility for XYZ physics. There are very good chances that the high statistics and quality of data at BESIII will lead to a final explanation of one of the most urgent puzzles in particle physics: Are there particles in the Universe with an exotic quark content and can we quantitatively understand their quark binding?The applicant of this proposal is the leading scientists at BESIII in the field of charmonium spectroscopy and will bring to Europe the expertise regarding XYZ physics. To keep track of these fascinating new results is of utmost for European research. Europe in near future will invest in major projects itself in this field. For instance in Darmstadt/Germany the PANDA experiment will investigate XYZ particles at the FAIR facility. Dr. Liu will cooperate with the PANDA team in order to shape its physics program. Secondly, theoreticians in Europe will have a chance to cooper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Revisiting critical issues in nuclear reactor design / safety by using 3-d neutronics / thermalhydraulics models: state-of-the-art' (CRISSUE-S), addressing dissemination and exploitation.

assistant: **Impact**

The evaluation of NPP performance in case of RIA, is concerned. The activity exploits computer, computational tools and knowledge recently acquired. Western and Eastern NPP are concerned. 3-D neutron kinetics codes are coupled with system thermal hydraulic codes to calculate complex scenarios in relation to which, either no evaluation is available or overly conservative NPP design and operation margins are adopted. The activity is of benefit for reducing NPP costs even in relation to new reactors, for quantifying the actual NPP safety, for optimising the use of nuclear fuel including Plutonium, for making more transparent and generally for advancing the nuclear technology. Transients that may cause core power excursions originated by sudden increases of moderator density are directly considered. Emphasis is given to the qualification processes needed to obtain data. Industry, regulators and research organisations are involved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Resurrection of Developmental Pathways in the Evolution of the Petal' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Our project concerns the evolution of petal conical cells in a group of flowering plants, the Caryophyllales. The fellow has determined that following a loss of petals in the Caryophyllales, petals have subsequently re-evolved 9 times. Conical cells, which perform a vital role in interacting with pollinators, often occur on these re-evolved petals. The host has demonstrated that MIXTA-like R2R3 MYB genes specify conical cells in distant lineages of flowering plants. We hypothesise that recurrent evolution of these conical cells in separate occurrences of re-evolved petals is due to repeated recruitment of the MIXTA-like R2R3 MYB genes. We will test this hypothesis by isolating R2R3 MYB genes from 3 species representing distinct evolutions of the petal in the Caryophyllales. We will conduct phylogenetic analyses to determine if the same or distinct lineages of R2R3 MYB genes have been recruited to specify conical cells. We will assess if the genes are expressed in the conical cells. We will perform a transformation assay into tobacco to determine if the MIXTA-like R2R3 MYB genes are functioning as in other flowering plants. We will analyse the function of the genes in vivo, through RNAi and overexpresssion. The host’s collaborators demonstrated that MIXTA-like R2R3 MYB genes are directly activated by the transcription factors APETALA3 and PITILLATA, to induce conical cells. However, the fellow has shown that APETALA3 and PISTILLATA are often absent from these re-evolved petals. We ask how MIXTA-like R2R3 MYB genes are turned on if APETALA3 and PISTILLATA are absent. We will answer this by analyzing the promoters of the R2R3 MYB genes to identify novel regulatory elements.  The fellow’s expertise on Caryophyllales petal evolution, combined with the host’s expertise on MIX
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Noč ima svojo moč (The Night has its Might), European Researchers' Night (NIGHT)'.

assistant: **Innovation**

Noč ima svojo moč [The Night has it might] (NOCMOC) [NIGHTMIGHT] project combines a strong awareness campaign embedding a major media campaign and a citizen science project with activities spread all over Slovenia. The core objectives of the NOCMOC project is to raise awareness about the research and its benefits, overcome stereotypes, stimulate curiosity all over Slovenia and excite youngsters to take up the research careers.The awareness campaign will comprise national TV broadcasts, radio broadcasts, press presence and a social media campaign, reaching 100.000 people. The innovative awareness campaign will be based on the Citizen Science Project – Chestnut tracking. We expect, over 1.000 groups, families and individuals will participate in the Citizen Science Project and experience the research methodology-hands on, and above all contribute to the basic research methodology of the real research project.The NIGHT activities will take place in 25 cities across Slovenia and will bring together over 30 research-related institutions to raise awareness about research and innovation, its social and economic benefits as well as its variety of careers. Over 30.000 visitors from different target groups will take part in the NIGHT activities spread all over Slovenia. Activities will combine science festivals on the main square of four cities,  science shows, simulations, research days in primary and secondary schools, lectures and workshops in public spaces such as libraries, retirement homes and museums, science espressos, EU corners, open doors at the research institutions, science centre and cultural institutions and many more - altogether over 200 individual activities in 24 hours from day  until night.


**Keywords:** research, innovation, science communication, researcher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Global mapping of second messenger c-di-GMP signaling networks in bacteria using proteomics' to be submitted under Horizon 2020.

assistant: **Abstract**

To survive in diverse niches, bacteria must adapt to changes in their local environment by sensing and responding to environmental cues. External cues are transduced through complex signaling networks throughout a cell and drive diverse changes in cellular behavior. In bacteria, cyclic di-guanosine-monophosphate (c-di-GMP) is a nucleotide-derived second messenger that mediates signal transduction of important biological processes for bacterial growth and survival e.g. motility, biofilm formation and metabolism. These biological processes are also crucial in clinical settings as they underlay antibiotic resistance in important pathogenic bacteria. Recent advances in MS-based proteomics have provided different tools to investigate the proteome of an organism in a systematic and global manner. Especially, thermal proteome profiling (TPP) and limited-proteolysis MS (LiP-MS) are pioneering methods to study change of protein states proteome-wide. I aim to employ these proteomics based approaches to achieve the global map of the c-di-GMP signaling network in two different bacteria, Escherichia coli and Caulobacter crescentus, both are model organisms of Gram-negative bacteria. Furthermore, I will apply these methods to investigate signaling network of another important second messenger, (p)ppGpp, and explore how the networks of these two messenger molecules interact in bacteria to dictate cellular physiology.


**Keywords:** second messenger, c-di-GMP, ppGpp, E. coli, Caulobacter crescentus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Protein-RNA interaction stabilization using molecular glues' (PRIGLUE).

assistant: **Concept**

Protein-RNA interactions play a key role in cell biology and there are limited tools for specific modulation. In this project we will look for molecules that act as glues by stabilizing the interaction between an RNA-binding protein and a specific RNA sequence which we call PRIGLUEs. The aims are to explore key concepts of how to develop screening methods to identify such PRIGLUEs and to determine what type of chemical matter is suitable for this approach. These novel molecular glues will be evaluated for their RNA selectivity and the mode of interaction stabilization. The methods we will develop to identify PRIGLUEs can be applied to any protein-RNA interaction, and we will use them to modulate the process of mRNA splicing to prove the concept. The glues will be applied to stabilize mutant splicing factor – RNA pairs to recover lost affinity and correct disease-causing splicing outcomes. PRIGLUEs will be applicable as novel tools for RNA biology studies but can eventually also lead to therapeutics with an unexplored mode of action.


**Keywords:** Molecular glues, protein-RNA interactions, Splicing