RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Learning Matters! The physics of continual learning in biological and soft matter' in the context of a Horizon Europe call.

assistant: **Objectives**

How many times have you wished you could simply pause your brain, only to find, to your frustration, that it is still busy, revisiting and processing inputs? Response to continual inputs is normal and essential, it is how we learn. In fact, any matter continually responds to input. Yet, our understanding of learning struggles with continual input.I here break with the current focus on the brain to uncover the physics of continual learning matter instead by investigating the emergence of learning bottom-up in life reduced in complexity to a network-shaped single cell – Physarum. Lacking any neurons, flows flushing throughout Physarum’s tubular network propagate input packaged as chemical concentration and flow shear force. Tube wall visco-elasticity re-organises in response – continually – learning its future response. Such mechanical learning serves as the blueprint for implementing learning in soft matter, as Physarum’s responsiveness in wall visco-elasticity has its soft matter twin in synthetic hydrogels. Implementing Physarum’s learning mechanics, cast in the language of theoretical physics, directly into soft matter, I uncover the physics of continual learning matter and, thus, develop biocompatible learning matter. My ambitious aim requires an interdisciplinary approach spanning biology, soft matter, and theoretical physics to1) reveal how Physarum learns as its matter mechanically responds to input,2) manufacture synthetic, soft matter flow networks that mimic Physarum’s learning mechanics, 3) derive a theory of continual learning from both biological and soft matter learning data to identify how learned behaviour is selected to last or vanish and4) apply soft matter learning to initiate proof-of-concept vascularised tissue implants.My conceptual insight may insp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The hidden majority: high-resolution imaging and genomics of the most ecologically important microbial eukaryotes in the ocean'.

assistant: **Objectives**

How have eukaryotes evolved into the vast diversity we see nowadays? At present this simple question remains a mystery, mostly due to the vast uncharted microbial environmental diversity recurrently unveiled by molecular surveys. This gap in knowledge hinders a deep understanding of basic eukaryotic diversity, evolution and biology, and creates a biased perception towards well-characterized organisms of human interest. Yet, since the beginning of microbial research, from Leeuwenhoek and Haeckel, unicellular eukaryotes have been largely studied by optical methods, describing an extensive variety of shapes and morphologies. We therefore need new and different approaches to explore unknown eukaryote diversity.The goal of this project is to better understand early and enigmatic eukaryotic evolution by studying the morphology and genomes of the most informative undescribed eukaryotic lineages. Studies of novel eukaryotic diversity have historically relied on arbitrary factors regardless of their environmental abundance due to the lack of data. Yet, abundant groups are the most practical to explore. I will first identify the most environmentally abundant species that are distantly related to morphologically described groups. Next, I will develop a novel approach that allows the acquisition of 3D morphological data by imaging group-specific fluorescence in situ hybridization probes in combination with a set of fluorescent dyes labeling relevant subcellular features. Finally, I will sequence and assemble their genomes to better resolve the eukaryotic tree of life, by filling out poorly represented lineages that are distantly related to well-characterized species. This project will bring for the first time the link between already available environmental short sequences and thei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Next generation versatile and effective AAV-mediated large gene delivery' (NextGeneTx).

assistant: **Innovation**

Despite 6 products on the market and dozens in advanced phases of clinical development, in vivo gene therapy with vectors derived from adeno-associated viruses (AAV) still faces the major challenge of the limited vector cargo capacity (< 5kb). This prevents AAV application for treatment of inherited diseases caused by mutations in large genes. To address this, we have recently developed an AAV-based strategy relying on the use of short protein elements called inteins. These, when fused at the extremities of fragments of a large protein delivered to cells through AAV, can mediate joining of the fragments in a traceless manner, resulting in the reconstitution of the intact target protein. However, despite being extensively utilized as biotechnological tools in vitro, the in vivo application of inteins for therapeutic purposes comes with several limitations. These include: insufficient levels of full-length protein reconstitution for some applications; complex design; and production of undesired, potentially harmful by-products. NextGeneTx aims to expand the potential of AAV-inteins as an innovative in vivo biotechnological tool for therapeutic purposes, by addressing each of these limitations. To achieve this, we will leverage cutting-edge technologies to: i. engineer inteins with improved efficiency and greater design flexibility; ii. modulate intracellular trafficking of intein-containing protein fragments to enhance the efficiency and accuracy of full-length protein reconstitution; iii. develop strategies to reduce the production of unwanted by-products. We will test the therapeutic relevance of evolved AAV-inteins in both gene therapy and genome editing applications, using human retinal organoids and animal models of retinal diseases. The outcomes of NextGeneTx will d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SME ACCESS TO R & D clusters: Development of Medical Technology:', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The project proposal involves SME's in innovation, research c-operation and EC programmes. The proposers are NCP's, Innovation centres and specialised consultants, interested in development of Medical technology for diagnostics and therapeutics. A SME scan will be executed to define possible participants. Guidelines to assist SME's for participation in MT research and development in the target area will be developed. The guidelines are directed at information on R & D and application of innovative products, implementation of new technologies in the production process and application for project grants for R&D. They take into account the incentives for SME's to participate, different EC implementation measures, specific capabilities of clusters and individual SME's, medical concerns as trends for innovation projects in MT, application possibilities in health care, feasibility. The work-plan contains annual workshops on results and progress and preparation of workshops and special courses for dissemination of knowledge to SME's. Progress can be measured with milestones and deliverables, resulting in scan outcomes, guideline documents, web site, meetings and workshops reports, future activities, and a final report with conclusions and recommendations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Euro-VO International Cooperation Empowerment' (EuroVO-ICE) targeting Seventh Framework.

assistant: **Abstract**

Astronomy has been a pioneer in the conceptualization and implementation of a science driven 'virtual infrastructure', essential to optimize the science return of the large infrastructures of the discipline. The concept of a Virtual Observatory (VObs) is that all the world's astronomical data should feel like they sit on the astronomer's desk top, analysable with a user selected workbench of tools and made available through standard interfaces across the whole range of astronomical research topics. VObs is embraced as a world-wide community-based initiative with the potential to transform and restructure the way astronomy research is done. The European Virtual Observatory, Euro-VO, is the European implementation of this idea. The astronomical VObs is undergoing significant evolution with the beginning of its operational phase. Some activities are critical and have to be maintained to assess their evolution and prepare them for being sustained on the long term. The EuroVO-ICE project is a 2-year focussed project which aims at preparing all the necessary measures to continue the pioneering work of Euro-VO and sharing its concepts with other scientific disciplines, (1) by exploring the key points for long term sustainability, including the international, European, and national perspectives, and (2) by assessing how to maximize the impact of the work on the VObs development and of Euro-VO achievements by building partnership with other 'neighbouring' disciplines – time for this coordination is now mature thanks to projects recently selected to be supported by EU funding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Researchers Night in Montenegro 2014/2015' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project Researchers’ Night in Montenegro 2014-15 will be a successful continuance of its precedents Researchers’ Nights 2009-2013, organized by the same consortium, Natural History Museum, Montenegrin Science Promotion Foundation – PRONA and Ministry of Science. Proposed actions will strengthen efforts in bridging the gaps between the researchers and wider public and to upgrade image of researchers within society. Main events will take place from the early afternoon of the last Friday in the September until following Saturday early hours, in years 2014. and 2015. Events will be organized at following venues in Podgorica, capital of Montenegro: a) National Library and Main Square - (200 Hands-on-experiments, Lego and other robots performance, Science Quiz, Creative experiments – final round of the competition for high school students, engineering competition for students (BEST), Science and Art installations, Gala opening, inter-generational workshops, ‘Open science Show’, Science cafe, Concert). b) Natural History Museum - NATURE CONNECTS US (hands on experiments, interactions with researchers).c) Shopping Mall Delta - family friendly events for kids (Science Cooking, hands-on experiments, and Funny Math).d) open and guided labs events in various locations in Podgorica (Uniiv. of Montenegro, Centre for Eco-Toxicological Research, Hydrometeorological-Seismological Service, wine company “13. jul – Plantaze”). There would be also smaller scale events in 7 more towns with interactive presentations (Tivat, Kotor, Danilovgrad, Nikšić, Bijelo Polje, Cetinje, Kolasin). Target groups of the projects are: researchers, high school students, university students, young people in general, preschool children, elementary school pupils, parents, school authorities and teachers, medi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Calibrating Exoplanetary Atmospheres Using Benchmark Brown Dwarfs' (CalExoPlan) targeting Seventh Framework.

assistant: **Abstract**

Low-mass brown dwarfs in wide binary systems with young stars provide unparalleled opportunities for critically testing and improving the atmospheric model grids that are fundamental to interpreting observations of giant exoplanets. By data-mining the latest generation of wide field infrared surveys (e.g. VISTA, UHS, WISE) to select a sample of benchmark L and T dwarfs that maximise overlap in parameter space with exoplanets, and have well constrained bulk properties such as age, temperature and metallicity, we will greatly improve  our ability to robustly characterise giant exoplanets. Detailed spectroscopic and photometric observations of this sample will provide crucial tests that will change the state of the art in atmospheric modelling. This International Outgoing Fellowship is devised to equip the fellow with detailed theoretical understanding of the complex atmospheric models that are fundamental to understanding the observations of giant exoplanets through a secondment with a world leading theorist. The knowledge gained during this phase will be leveraged during the return phase such that the full scientific potential of this ambitious survey may be realised.  Substellar and exoplanetary models are extremely complex and their production is an inherently multidisciplinary exercise in physics, chemistry and high-performance computing. They incorporate gas phase and surface chemistry, molecular opacities, condensate clouds, composition variations, atmospheric dynamics and radiative transfer. By pursuing this project, the Fellow will develop a unique cross-disciplinary skill set and combination of expertise spanning the observational and theoretical aspects of understanding substellar and exoplanetary atmospheres, bringing significant benefits both in terms of caree
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Scalable method for production of fatty commodity e-chemicals from recycled CO2' (CO2Chains), addressing dissemination and exploitation.

assistant: **Impact**

Aliphatic organic compounds are an essential class of platform chemicals in a wide range of industries. They account for a global market volume exceeding 20 EUR billion per year. However, their production currently relies on fossil-based petrochemicals and deforestation-linked natural oils, contributing significant net greenhouse gas emissions and facing strict EU regulations aimed at phasing out unsustainable production practices.The CO2Chains project proposes a groundbreaking solution by synthesizing a wide variety of industrially relevant chemicals directly from sustainable and lower-cost C1 carbon sources. Unlike conventional multistep processes, this method catalytically converts renewable C1 raw materials into aliphatic organic compounds with high chemo- and regio-selectivity under mild conditions. This innovation eliminates the need to feed costly, preformed precursor compounds, drastically reducing feedstock cost, and aligning with current and upcoming EU directives on the environmental impact of chemical production.The project aims to demonstrate the economic feasibility of CO2Chains. It focuses on upscaling the new manufacturing concept, with a strong emphasis on product benchmarking, a critical factor for customer acceptance and regulatory compliance. Techno-economic and market analyses will culminate in a robust business case for this technology, which transforms waste CO2 into high added-value and global-demand chemical products. This advancement represents a significant step forward in sustainable manufacturing and supports the principles of a circular economy.


**Keywords:** Sustainability,  catalysis,  CO2 recycling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The Bacillus subtilis circadian clock:  from molecules to mutualism'.

assistant: **Concept**

Circadian clocks are biological timekeepers. They structure processes - from molecular pathways to behavioural attributes - over the 24h day. They are pervasive in eukaryotes yet remain almost completely unknown in bacteria. We propose to address this major knowledge gap by capitalising on our recent breakthrough discovery of a circadian clock in Bacillus subtilis. Our unpublished data reveal that robustness of the B. subtilis circadian clock increases when co-cultured with either the plant Arabidopsis, or the yeast Saccharomyces cerevisiae. We propose that the mutualistic interactions between microbes and other organisms in their environment utilise circadian clocks, allowing us to propose the new concept of “temporal mutualism”. Within this project, we will identify and understand the molecular structure and function of the B. subtilis circadian clock (WP1), which will be the first detailed characterisation of a circadian clock in a non-photosynthetic bacterium. We will exploit the interactions that occur between B. subtilis and plant circadian clocks to define this new concept of temporal mutualism (WP2 and 3). Co-culture of B. subtilis with S. cerevisiae will identify regulatory nodes that are common to plant/bacterium and fungus/bacterium temporal mutualism (WP3). We will probe the novel hypothesis that biofilm enables intra-species temporal mutualism via differentiated cell populations within the matrix-bound structure (WP3). We will use circadian formalisms (behaviour), molecular systems analysis and state of the art technological approaches (e.g., combinations of microfluidics, microscopy, reporter gene technology and optogenetics), which is only possible through our interdisciplinary collaboration. This work will drive a paradigm shift, to open a completely new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Linking genetic resources, genomes and phenotypes of Solanaceous crops' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

G2P-SOL is a research alliance bringing together the major European and International repositories of germplasm with public and private institutions active in genomics, phenotyping and breeding in the four major Solanaceous crops: potato, tomato, pepper and eggplant. These four crops constitute 66% of the value of European horticultural production, and over 65,000 accessions are available within the consortium. By harnessing the available global biodiversity, novel genotyping and phenotyping concepts and data analysis tools, the G2P-SOL project will link the genetic code underlying Solanaceae biodiversity with the traits that improve productivity, adaptation and human health. By making this information accessible to end-users, the awareness of the available diversity will be increased and use of this genetic diversity in breeding programs will be stimulated, resulting in diversified production chains. The phenotypes and traits of material held in European and major international collections will be described using common ontology terms developed in this project and this information will be housed in an open source software platform, allowing easy interfacing with existing platforms for germplasm cataloguing. G2P-SOL will develop shared values in science and education in the following areas: 1) Defining and maintaining genetic pools for crop improvement. 2) Phenomic and genomic data: generation, analysis, storage, and linkage with gene banks. 3) Pre-breeding and germplasm enhancement. 4) Training, workshops and public outreach. G2P-SOL will redefine how to manage and organize genetic resources and linked genomic and phenomic information in a manner that will make them accessible to naturalists, geneticists and breeders for conservation, scientific research, and breeding