RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Investigating the role of HIFs in myeloid cells during experimental choroidal neovascularisation' to be submitted under Seventh Framework.

assistant: **Abstract**

Age-related macular degeneration (AMD) is the commonest cause of blindness in the developed world. AMD is a progressive disorder of the outer retina characterised by the accumulation of extracellular deposits and chronic inflammation at the level of Bruch’s basement membrane. Photoreceptor cell death is the result of progressive (‘geographic’) atrophy of supporting retinal pigment epithelium (RPE), or disruption by pathological neovascularisation that arises from the choroid and penetrates defects in Bruch’s membrane. Choroidal neovascularisation (CNV) develops in response to the up-regulation of multiple pro-angiogenic cytokines, including vascular endothelial growth factor (VEGF), in the context of an abnormal extracellular matrix. The outcome of neovascular AMD can be improved by intraocular delivery of VEGF inhibitors but this is incompletely effective, indicating the involvement of additional parallel pathways or compensatory mechanisms. There is a clear unmet need for more effective treatments. In this fellowship I will investigate the hypothesis that HIF activation in myeloid cells is responsible for neovascular AMD. By defining the role of HIF in myeloid cells in the development of experimental CNV I aim to identify new opportunities to improve the efficacy of therapeutic intervention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Elongase 6 and thermogenesis'.

assistant: **Objectives**

Obesity is the result of a mismatch between energy intake and energy expenditure. Excess calories will end up as fatty acids which can be stored, exported to other tissues, oxidized or transformed to lipid metabolites. Little is known of how these lipids are targeted to these various fates. Brown adipose tissue (BAT) is an organ with high rates of lipid oxidation and large cellular lipid stores, making it an ideal organ to investigate lipid targeting. The elongase Elovl6 can elongate mono and poly unsaturated fatty acids of C12 or above. The expression of elongases is highly regulated in BAT, particularly by the cold. In a recent publication on the metabolic characterization of Elovl6 KO mice it was noted that, for unknown reasons, these mice had lower body weights despite normal food intake. We suggest that the extremely high expression levels of Elovl6 in BAT indicate a potential involvement of Elovl6 in the regulation of thermogenesis and thus in the regulation of body weight. The aim of this fellowship is to investigate the role of fatty acid chain length on control of fatty acid oxidation, focussing specifically on the fatty acid elongase Elovl6. To that end we will use both cellular techniques and genetically modified animal models with a loss of function of Elovl6. First we will determine the role of Elovl6 in BAT differentiation, lipogenesis and function in vitro. Primary cultures of brown pre-adipocytes obtained from Elovl6 KO and WT mice will be used to study brown adipocyte differentiation and lipogenesis, oxygen consumption and fatty acid oxidation. Secondly, we will determine the role of Elovl6 on energy balance. Elovl6 KO and WT mice will be placed into metabolic chambers for extensive metabolic phenotyping (simultaneous measurements of oxygen consumption,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Stimuli-Responsive Two-Dimensional Materials for Renewable Energy'.

assistant: **Innovation**

I will engineer van der Waals (vdW) heterostructures of two-dimensional (2D) materials with tuneable electrochemical response for exploitation in renewable energy applications. These heterostructures, which are constructed by stacking 2D crystals on top of each other, have been attracting increasing attention in solid-state physics, optoelectronics, and photonics but their full potential in electrochemical applications such as energy storage, conversion, and sensing remains completely unexploited. I will control their electrochemical response by external stimuli including electric field, strain, and illumination. In order to succeed, I will first develop a solid understanding of the unexplored key electrochemical properties of 2D materials and their dependence on these stimuli. I will fully exploit my recent experience in 2D materials’ research and the access to the world-class nanofabrication and characterisation facilities and scientific expertise at Cornell University, the University of Manchester, and National Physical Laboratory.This research is motivated by the ever-increasing need for reliable sources of renewable energy, which will provide clean and inexpensive electric energy and address the irreversible depletion of fossil fuels. However, the intermittent nature of renewables (day-night, tidal, and weather cycles) does not permit on-demand supply of electricity. Energy conversion and storage technologies, whose majority relies on electrochemical interfaces, balance this ‘demand vs. supply’ mismatch and prevent energy wastage. The topic of my fellowship is in an excellent alignment with the long-term research strategies within the Horizon 2020 and Graphene Flagship EU programmes. The proposed research will have a significant impact on target areas of EU energy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Global Omic Data Integration on Animal, Vegetal and Environment Sectors' (GLOMICAVE) targeting Horizon 2020.

assistant: **Abstract**

Massive increases in analytical throughput together with reductions in costs have enabled multi-omics studies to be routinely performed at a scale not previously imagined. Two main barriers hamper our ability to reveal the mechanism behind a specific genotype-phenotype link: the cross-talk between multiple molecular layers cannot be properly assessed by a reductionist approach that analyses each omics layer in isolation; and the ever-growing amount of buried information in scientific literature and public omics datasets cannot be extracted without intelligent computational approaches. GLOMICAVE project addresses the need for building systems that allow streamlining both the experimental design and the analysis and integration at a systems level of large-scale omics experiments by maximizing the utility of pre-existing massive omics datasets and scientific literature to increase the understanding of biological systems as a whole.The main outcome will be a multi-omics data analysis cloud-based platform, relying on Big Data Analytics and Artificial Intelligence techniques – and using large-scale publicly available and experimental omics datasets, enhanced with an automatic processing of scientific literature, to assist experts and non-experts in identifying and understanding new links between genotype and phenotype which apply to different domains. GLOMICAVE integrative approach will be validated in 3 different industrial sectors (livestock, agro-biotechnology and environment) addressing specific challenges in 6 business cases, which will pave the way for further uptake in other business areas. The success of GLOMICAVE builds upon the expertise of a multidisciplinary team of 14 partners with expertise in omics sciences; standardization; bioinformatics; environmental assess
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Accurate and Scalable Processing of Big Data in Earth Observation' (BigEarth) targeting Horizon 2020.

assistant: **Abstract**

During the last decade, a huge number of earth observation (EO) satellites with optical and Synthetic Aperture Radar sensors onboard have been launched and advances in satellite systems have increased the amount, variety and spatial/spectral resolution of EO data. This has led to massive EO data archives with huge amount of remote sensing (RS) images, from which mining and retrieving useful information are challenging. In view of that, content based image retrieval (CBIR) has attracted great attention in the RS community. However, existing RS CBIR systems have limitations on: i) characterization of high-level semantic content and spectral information present in RS images, and ii) large-scale RS CBIR problems since their search mechanism is time-demanding and not scalable in operational applications. The BigEarth project aims to develop highly innovative feature extraction and content based retrieval methods and tools for RS images, which can significantly improve the state-of-the-art both in the theory and in the tools currently available. To this end, very important scientific and practical problems will be addressed by focusing on the main challenges of Big EO data on RS image characterization, indexing and search from massive archives. In particular, novel methods and tools will be developed, aiming to: 1) characterize and exploit high level semantic content and spectral information present in RS images; 2) extract features directly from the compressed RS images; 3) achieve accurate and scalable RS image indexing and retrieval; and 4) integrate feature representations of different RS image sources into a unified form of feature representation. Moreover, a benchmark archive with high amount of multi-source RS images will be constructed. From an application point of vi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Generation and maintenance of long-lived memory T cells in humans' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Defining the molecular mechanisms governing memory T cell differentiation and homeostasis is of pivotal importance to generate durable and protective T cell responses against infections and cancers. Considerable knowledge in this regard has been acquired in mouse models but is still limited about human T cells. In particular, some mechanisms are assumed to occur in humans but were never formally demonstrated. We showed that memory T cells adoptively-transferred with bone marrow transplantation failed to persist in recipient hosts in the absence of antigen. By contrast, self/tumor-specific naïve T cells rapidly acquired T memory stem cell (TSCM) attributes and subsequently reconstituted the memory T cell pool by homeostatic differentiation. Current models indicate human TSCM cells as superior to conventional memory T cells in regards to effector potential and persistence capacity. Genome-wide expression analysis identified candidate TSCM cell-specific transcriptional regulators that were shown to inhibit senescence, promote self-renewal and regulate somatic differentiation. In this project, by using single cell technologies, primary human samples and in vivo humanized models, we will define the molecular mechanisms at the basis of memory T cell formation and maintenance in humans. We will initially define the antigenic requirement for the long-term persistence of memory T cells by following the fate of adoptively-transferred T cells. As the field remains unexplored, we will investigate the acquisition of memory attributes by self/tumor-specific T cells on multiple functional levels. The gene products specifically expressed by self-renewing TSCM cells will be finally tested for their capability to arrest T cell differentiation and generate long-lived memory T cells with e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A rapid, non-invasive, cost-effective, analytical device for bacterial or viral infection diagnosis through ultra-high sensitivity breath analysis.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The world faces a growing epidemic of antimicrobial resistance (AMR); however, only two new classes of antibiotics have been brought to the market in the last 30 years. The discovery and development of new antibiotics is essential to maintain medical advances but poses significant scientific, clinical, and financial challenges, particularly for antibiotics active against Gram-negative bacteria (such as E. coli). Such bacteria have effective barriers against drugs, making treatment difficult, resistance likely and development costs and risks high. In addition, any new antibiotics brought to the market would likely be used cautiously to delay the development of resistance, adding an additional financial challenge in recouping the development costs. The O’Neill Report on AMR identifies diagnostics as critical to the battle against antibiotic resistance.This innovation action, BreathSpec, proposes a viable solution to the global problem of AMR through the final developmental stages of an existing diagnostic device, which will allow a rapid, binary decision to be made on the need for antibiotic treatment, and which with suitable optimisation will allow further differentiation and stratification to take place. The Innovation Action includes technical developments to optimise its function, data acquisition for the development of the decision making analytical function and clinical validation.It addresses these issues by producing reliable identification and quantification of key signature volatiles present in exhaled breath. It provides a non-invasive method for monitoring the volatile organic compounds present in an individual’s exhaled breath (and subsequently the blood) and has long been recognised as having significant utility as a clinical test that can be used for early
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'BioAlkane'.

assistant: **Innovation**

BioAlkane will provide the proof-of-concept for the economic and ecological feasibility of a new concept for the valorisation of waste fatty acids as alkanes useful for the energy and transportation sector. Using a new catalyst class (photodecarboxylases) we will establish a completely new method for the conversion of fatty acids into alkanes (instead of the traditionally used fatty acid methyl esters). Using a novel photoreactor design, we will overcome current limitations of photobiocatalysis (i.e. low quantum efficiency due to poor light penetration into the reactor) and demonstrate the scaleability and economic viability of our next generation of biodiesel.


**Keywords:** biodiesel,  biocatalysis,  photochemistry,  renewable feedstock
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Transition towards a more carbon and nutrient efficient agriculture in Europe'.

assistant: **Concept**

NUTRI2CYCLE will use an integrated approach to enable the transition from the current (suboptimal) nutrient household in European agriculture to the next-generation of agronomic practices, characterized by an improved upcycling of nutrients and organic carbon. The project is deeply rooted in pevious national and European projects, in which the consortium members were actively involved. The underlying principle is that Nutrient Use Efficency can be significantly improved by integrating on-farm techniques and systems that allow better reconnection between 1) animal husbandry provided flows and 2) plant production requirements. At the same time this reconnection itself will serve a better C-return to soil and GHG-reduction by avoided emissions optionally combined with energy production for self-consumption on-farm.NUTRI2CYCLE aims to (i) benchmark mass flows of nutrients, organic carbon and GHG-footprint, (ii) provide an assessment frame (toolbox) for evaluating potential impact of proposed innovations, (iii) actively support concepts, techniques and scenarios put forward in EIP-Operational Groups, (iv) optimize these (+ in-consortium developed) scenarios using the toolbox, (v) showcase the most promising developments via prototypes and demos. Finally, using the experience gained at a local/regional scale, NUTRI2CYCLE will elaborate strategic scenarios to identify the effect of these innovations at European scale. NUTRI2CYCLE brings together the extensive expertise of leading experts in the field of nutrient cycling. This collaboration originates from the EIP-Focus Group on Nutrient Recycling, closely interacting with the EIP Operational Groups in the individual EU member states. Better nutrient stewardship engaging all actors across the value chain as envisaged in NUTRI2C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart, flexible, decentralized water treatment' (M-NBS), addressing dissemination and exploitation.

assistant: **Impact**

Although in EU countries, the access to sanitation is universal in urban areas, Eastern Europe, the Caucasus and Central Asia (EECCA), all belonging to the European WHO Region, lack adequate access to water services. Indeed, more than 4.3 million people still rely on surface water as their primary source, posing severe risks to health. 90% of people using surface water live in rural locations. The main reason of this inequality is of economic nature. Given the low economic capacity of the mentioned areas in public infrastructure, the investments in water services are addressed at the highly populated areas. Ayala is a SME company with 8 employees whose mission is to bring the knowledge in the field of phytoremediation to an operative level by creating tools to restore balance to the environment employing natural mechanisms without consuming energy. With this goal, we aim to developed a modular Natural Biological System™ (M-NBS), a sustainable natural technology for treating sewage and waste streams, rehabilitating affected water bodies and rebalancing watersheds. The system, which has been successfully applied NBS in more than 100 large scale natural sanitation and remediation projects as non-mobile unit, is based on a proprietary phytoremediation technology capable to treat 7 to 70 m3 water/day per cubic meter of the system depending on the water pollution level. Our goal is to achieve a market penetration for M-NBS in Eastern European and neighboring countries so that we manage to service 5 % of 62 million people in the region without access to sanitation Europe in the next 5 years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Study of the interaction between metabolic stress and a specific genetic background on the contribution of sporadic Alzheimer's Disease' (2014-2020).

assistant: **Concept**

Different from the familial forms, late onset Alzheimer’s disease (LOAD) is not the consequence of a single cause: neither aging, nor genetic polymorphisms nor an environmental disturbance do, per se, suffice to produce this disease. It is currently thought that instead disease is the consequence of an interaction of all the above circumstances. With that perception in mind, I here propose to study i) the effect of type 2 diabetes mellitus (T2DM), a metabolic disturbance strongly associated with propensity to LOAD, on the appearance of AD-associated features (biochemical, electrophysiological and behavioral) ii) in the brains of aged mice iii) bearing a genetic insufficiency in either the gene SORL1 or in CD2AP, both of which have been linked to higher risk of late onset AD in recent familial genome wide association studies (GWAS). Once the phenotypic analysis is completed, I will perform genome wide epigenetic analysis of T2DM on specific neuronal populations of wild type and the genetically deficient mice. All in all, my studies should help to determine the mechanisms by which environment, age and disease-predisposing genetic weaknesses link together to produce this disease.