RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Exploring the mechanisms of long-term tumour evolution and genomic instability in marine transmissible cancers', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Cancers are proliferative outgrowths of abnormal cells driven by a selfish evolutionary programme. Most cancers arise from and remain within the bodies of their respective host individuals. Rarely, however, cancers may escape their hosts to become ‘transmissible cancers’, infectious cell lineages that spread between individuals by direct transfer of cancer cells. As parasitic cancers capable of surviving for millennia, transmissible cancers offer a unique model for exploring how mutation, selection and cellular processes mould and constrain selfish tumour evolution.Marine bivalves (shellfish including clams, mussels and cockles) are affected by at least 10 transmissible cancers, which spread via waterborne cell transfer. The recurrent emergence of long-lived cancers in shellfish provides a valuable resource for comparative studies aiming to probe the basic mechanisms of tumour evolution, including extreme genomic instability. Yet, the evolutionary histories of these cancers are poorly understood.My vision is to elucidate the origins and evolution of marine transmissible cancers by conducting a large-scale comparative genomic study of these cancers. My aims are to:1. Understand how transmissible cancers arise, mutate and spread under the sea2. Identify the mechanisms and consequences of genomic instability in transmissible cancers.My research approach will involve:- Extensive tumour sampling across continents- Generation of high-quality bivalve genome assemblies- Application of state-of-the-art technologies, including laser microdissection and single-cell sequencing, to hundreds of tumours- Development of specialised methods for comparative cancer genome analysis.The intrinsic heterogeneity and short lifespans of most cancers may obscure their underlying biological patte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European Coordination for Accelerator Research and Development' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Particle physics stands at the threshold of a new era of discovery and insight. Results from the much awaited LHC are expected to shed light on the origin of mass, supersymmetry, new space dimensions and forces. In July 2006 the European Strategy Group for Particle Physics defined accelerator priorities for the next 15 years in order to consolidate the potential for discovery and conduct the required precision physics. These include an LHC upgrade, R&D on TeV linear colliders and studies on neutrino facilities. These ambitious goals require the mobilisation of all European resources to face scientific and technological challenges well beyond the current state-of-the-art and the capabilities of any single laboratory or country. EuCARD will contribute to the formation of a European Research Area in accelerator science, effectively creating a distributed accelerator laboratory across Europe. It will address the new priorities by upgrading European accelerator infrastructures while continuing to strengthen the collaboration between its participants and developing synergies with industrial partners. R&D will be conducted on high field superconducting magnets, superconducting RF cavities which are particularly relevant for FLASH, XFEL and SC proton linacs, two-beam acceleration, high efficiency collimation and new accelerator concepts. EuCARD will include networks to monitor the performance and risks of innovative solutions and to disseminate results. Trans-national access will be granted to users of beams and advanced test facilities. Strong joint research activities will support priority R&D themes. As an essential complement to national and CERN programmes, the EuCARD proposal will strengthen the European Research Area by ensuring that European accelerator infrastructures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EVOLchip - predicting antibiotic resistance for sustainable antibiotic stewardship' (Evolchip) targeting Horizon 2020.

assistant: **Abstract**

Antibiotic resistance is rife (fig. 1), yet notoriously difficult to predict. Here I propose to assess the applied potential of an easy to use device, ‘EVOLchip’  that allows to test antibiotic treatment schemes within a few weeks for their risk of inducing antimicrobial resistance.  If successful, this would allow to use current antibiotics much longer and to reuse old antibiotics in combination. Such tests can be conducted at hospital level by any trained medical microbiologist and hence be implemented into routine antibiotic stewardship. The proposed project entails (a) a praxis test with an enduser, a large university hospital, (b) an IPstrategy (c) a market and competitor analysis (d) a finance plan (e) a strategy to engage industrial partners and end-users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Economics of Grievances and Ethnic Conflicts' (GRIEVANCES).

assistant: **Concept**

I analyze theoretically and empirically the role played by grievances and hostile beliefs in ethnic conflicts. I study the interaction between economic incentives, endogenous salience of ethnic identities, belief dynamics and conflicts. In particular I analyze the formation of oppositional ethnic identities, which correspond to group-specific systems of beliefs leading to distrust and use of violence. Those issues are at the intersection of the literatures on the economics of conflicts and the economics of social identity. They involve both micro- and macro- aspects. I provide an applied theory framework to articulate the analysis and I perform both experimental and empirical investigations to test the main theoretical predictions.The project is ambitious but realistic. It has the potential for important contributions to the current literature: the topic is important, original and unexplored using formal and quantitative methods. My methodological approach encompasses state-of-the-art theory and thought-provocative empirical strategies. The approach is grounded in quantitative economics. However the proposal draws many insights from other disciplines in the social and biological sciences.This proposal is a revised version of my research project which was selected for the second step of the previous ERC 2011 call.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Revealing 3D Atomic Structure and Chemistry in Scale-Bridging Volumes via 5D Hyperspectral Electron Tomography' (HyperScaleEM).

assistant: **Concept**

Electron microscopy is essential to understanding structure-property-function relationships in modern materials engineering, condensed matter physics, chemistry, and structural biology. Yet, due to complicated scattering physics, todays electron microscopes can only image tiny volumes with 3D atomic resolution. Within this project, I will turn the tables by utilizing and inverting the scattering physics to image scale-bridging volumes with atomic detail and chemical superresolution. Combining compressive data-acquisition protocols, state-of-the-art electron optics and detectors, and co-designed computational imaging algorithms will make this possible. I will use tomographic experiments and computationally invert the multiple scattering from multidimensional measurements in scanning transmission electron microscopy to determine 3D atomic structure and chemistry in technologically valuable volumes. This has not been realized yet due to significant bottlenecks in the computational complexity of the underlying algorithms and a lack of experimental automation, which I plan to overcome in this project.The project is divided into three main objectives:1) Imaging 3D atomic structure in large volumes 2) Visualizing atomic chemistry in scale-bridging volumes3) Profiling 3D atomic structure, chemistry, and dynamics in controlled in-situ experiments across scales These methods will be applied to essential materials, including examining single hydrogen atoms at grain boundaries in structural metals and studying concealed, extensive interfaces in modern semiconductor materials.  In the final phase, I will record atomistic movies of material fracture in tungsten and alloys. Fracture is one of the most critical failure modes of structural materials with catastrophic consequences. The d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Digital Summit 2025 (16-18 June 2025, in Gdańsk (Poland))' in the context of a Horizon Europe call.

assistant: **Objectives**

The Digital Summit will be an annual event hosted by the European Commission and the Member State presiding over the Council of the European Union. It’s a forum addressing important issues of the digital transformation. The Digital Summit (DS25) will be hosted by the Polish Presidency at the European Solidarity Centre in Gdańsk, Poland, on 16-18 June 2025. This three-day event will focus on SMEs & scale-ups, their digital competitiveness and innovation, exposure to digital regulations and absorption of digital technologies. The Digital Summit concurs with the EC’s economic priorities, namely: -cutting the red tape for SMEs, -securing the potential of European entrepreneurs, -building up the EU’s competitiveness through investment and innovation, -building up the EU’s own capital.The EU’s digital ambitions for 2030 require Member States to focus on digital regulations, secure and sustainable digital infrastructure, digital transformation of SMEs and digitalisation of public services. We believe that EU Member States face various challenges arising out of these processes. With the help of cooperation and innovation we can transform the EU into a strong and resilient Digital Single Market. With DS25, Poland seeks to highlight the challenges and opportunities that are vital to a continued secure and open digital transformation withing the Digital Decade framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Technology, Economics and Diversity in the Periphery'.

assistant: **Innovation**

A study across six peripheral European regions that addresses the nature of existing and potential change emanating from the introduction of new IST. The regions have been selected on an experimental basis that allows us to explore the relationship between population size and diversity and trajectories of development associated with IST. Within each region it considers the nature of these IST based developments by reference to convergence and digitalisation and their impact upon the reconceptualisation of resources. The impact of these developments on learning, organisational structures, service provision, plans to sustain diversity and potential for expanding the network economy are similarly considered. This allows the study to ascertain the extent to which the different regions are moving towards a coherent process of development. The end product for each region is a business model for future integrated development.Objectives:This project seeks to explore how development towards the Information Society and the Knowledge Economy is progressing within six European regions - Wales in the UK, Catalunya in Spain, Carinthia in Austria, East Savo in Finland, the west of Ireland and Szekesfehervar in Hungary. It seeks to develop measures of this progress, which will lead to establishing a technology watch for the regions. At the heart of the work is a concern with the regional development of the digital value chain and the way that it informs convergence between television and the web and how this pertains to content provision. In developing a business model for the regions the project moves towards outlining a coherent plan for trans-regional development. In this respect it also considers the relevance of the work by reference to other regions in the European periphery.Work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Identification of genes involved in mouse cns development using gene trapapproaches and analysis of phenotypes generated by insertional mutations'.

assistant: **Objectives**

Research objectives and content I intend to use the gene trap strategy to identify novel genes involved in mammalian CNS development. The approach utilizes murine embryonic stem cells (ES) and a-gal-carrying reporter vectors containing a splice-acceptor site. Upon integration of these vectors into introns a fusion transcript between the endogenous gene and the ,B-gal gene is generated. A gene recently isolated in the host laboratory using the gene trap methodology is involved in the general apoptosis pathway. The aim of this project includes the phenotypic analysis of the generated insertional mutation, and the functional characterization of the trapped apoptotic protein. Training content (objective, benefit and expected impact) I acquired a strong background in molecular biology, during several years of work on RNA processing in Xenopus laevis. I recently acquired technical and theoretical skills in mouse embryology. My objective is to broaden my knowledge in the transgenic mouse technology, and to use the gene trap approach to better understand CNS development and the role played onby apoptosis. A training of 24 months in the field would give me enormous career benefits and the possibility to carry out afterwards, in my country of origin, the learned techniques and know-how so far related to only very few labs. Links with industry / industrial relevance (22) Besides MPI, AMGEN Research Inc. supports the general direction of gene trap technology in the host laboratory. My project is linked to the establishment of the European Mouse Mutant Archive (EMMA) in Monterotondo (IT). Moreover, several clinical applications are linked to the characterization of the apoptosis factor I am working with (i.e.: cancer therapy and processes of inflammation)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Behavioral, immunological and virologic correlates of hiv-1 superinfection (hiv+ vs hiv++) in rural tanzania' under Fifth Framework.

assistant: **Concept**

HIV infection is not always protective against super infection by a second strain, but little data is available on circumstances of super infection. We propose to investigate prevalence, incidence, virology, immunology, clinical, and social factors associated with super infection in a cohort of highly exposed bar workers (600) in rural Tanzania, where 3 HIV-1 subtypes co-circulate (A,C,D). Once enrolled by voluntary consent, social research on parameter of cohort and the community, regular STI treatment and health care, and counselling on HIV prevention will be delivered and blood and CVL collected every 3 months for 3 years. Our study will help to determine whether super infection can occur in the face of a fully developed immune response, will define its natural history and virology outcomes, including emergence of recombinants, and will provide a new and innovative approach to define correlates of protective immunity for vaccine development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electric Smart Eco Vacuum Pump For Green Cars' (ESEV-4-GR) under Horizon 2020.

assistant: **Objectives**

ENTECNIA is one of the independent engineering firms on a global level that has the most capacity and experience in automotive Brake Function, and has so far invested (since 2012) more than €1.5 million in the development and validation of this technology/component, a new safety component on the global forefront of automotive technology that minimizes CO2 emissions from new cars, in accordance with Regulation No. 443/2009 of the European Parliament.The product (5 major innovations and consist IP strategy protection) is an autonomous and optimized integrated system for the vacuum generation and management in a vehicle, that provides, as an added value, the modularity, a significant improvement to technical performance, incorporates new materials in its manufacturing, reduces fuel consumption/emissions of the vehicle by 50%, incorporates intelligence into this safety feature, and provides high flexibility in its installation. It is also very competitive economically and could be installed in most fleets of vehicles that will be manufactured in the future, especially within the Green Car segment.The new component can meet the 2020 target to reduce vehicle emissions in the EU and with the specifications of the new generation of environmentally friendly vehicles, which will form the majority of the overall vehicle fleet during the period between 2016-2026. The company plans to apply for and obtain approval as eco-innovative technology for this product (according with Regulation No. 443/2009). ENTECNIA has estimated the potential market for electrical vacuum pumps could be about 128 million units over the next 10 years, and estimates it could obtain an average share of 15% of this market, about 16 million units in the period between 2017-2026. The main customer groups of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DNA-Fast light dRiven data technologY with multiplexed optical encoding and readout' under Horizon 2020.

assistant: **Concept**

Modern society has an ever-increasing need for long-term, high density data encoding and storage. DNA technology allows to store data at unprecedented density, and functionalized DNA integrates digital bits placed along a single strand to encode information, which is available at low cost with natural (not-synthetic) DNA. DNA-FAIRYLIGHTS will raise this concept of functionalized natural DNA for data encoding and storage to a completely new level by decorating DNA carriers with a precise sequence of metallic nanomaterials with well-defined optical responses. These hybrid DNA structures will allow for direct optical readout, and the different resonance wavelengths will allow to go far beyond (0,1) encoding. In DNA-FAIRYLIGHTS we will design ultrasmall plasmonic and light-emitting particles with at least 9 different distinct optical responses that will enable multiplexed data encoding. We will develop concepts for linking/unlinking and orientational reconfiguration by external stimuli that will allow for reconfigurable memories and computation. The DNA-FAIRYLIGHTS project will provide: (i) a revolutionary technology that utilizes the DNA to arrange metallic nanomaterials in sequences with with nm precision;  (ii) a novel approach to fabricate functionalized DNA that allows for integration of metal nanomaterials for data storage and manipulation; (iii) a next-generation model to encode and store information along the DNA; (iv) an optoelectronic/microfluidic system to modulate the arrangement of the metallic nanostructures along the DNA in order to dynamically control the information content;  (v) readout devices with single particle sensitivity with fast response and decoding of the stored information in one functional unit. Each result of DNA-FAIRYLIGHTS will provide mile