RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Uncertainty and Precaution: Environmental Decisions Involving Catastrophic Threats' to be submitted under Horizon 2020.

assistant: **Abstract**

The goal of this project is to supplement or replace the precautionary principle with decision guidance that better handles both normative and empirical uncertainty in contexts of speculative but potentially catastrophic consequences. It has been claimed that emerging technologies such as geoengineering, biotechnology, or machine intelligence could have catastrophic impacts on human civilization or the biosphere, indicating the need for precaution until scientific uncertainty has been resolved. Yet it is unclear how to apply the precautionary principle to cases where the deeper investigations of scientific uncertainties that it calls for can themselves be a source of catastrophic risk (in e.g. gain-of-function research and geoengineering experiments). Furthermore, the precautionary principle fails to account for moral uncertainty —even though many decisions depend more sensitively on ethical parameters (e.g. our obligations to future generations, discount rates, intrinsic value of nature) than on remaining scientific uncertainties.Building on recent advances in decision theory, computational modelling, and domain-specific risk assessment techniques, and using tools of analytic and moral philosophy, this project will: (1) develop methods that account for normative uncertainty by combining voting theory with ongoing work on moral uncertainty, identifying parameters that make the largest practical difference; (2) combine these with methods for dealing with sources of empirical ignorance (such as information hazards, anthropic shadow, model uncertainties) into a theoretically well-motivated framework that comprises normative and empirical uncertainty; (3) derive mid-level principles and procedures from this theoretical framework by working through three case studies (geoeng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Co-ordinating project for electronic authors right management systems' in the context of a Fourth Framework call.

assistant: **Objectives**

The primary objective is to assist the vertical projects" concerned with IPR (Intellectual Property Rights) management and co-financed by the European Commission. The aim is to do this by taking advantage of the experience gained in an earlier ESPRIT Project, CITED (EP 5469, Copyright In Transmitted Electronic Documents). This will support the development and implementation of an interoperable IPR ECMS (Electronic Copyright Management System). A related objective is to cooperate with the vertical projects in a standardisation process that is necessary to permit interoperability among different ECMS.These objectives will be met through the following processes:- an identification and feasibility study of coordination with the vertical projects concerned , including an analysis of their business cases- transfer of the CITED technical expertise and, possibly, existing technology for rapid implementation, maintenance and upgrade of the CITED model- examination of legal IPR issues- preparation of pre-standards in the area of IPR identifiers and EDI/ECMS messages- organisation of ECMS proficiency centres and of ECMS technology and standards SIGs (Special Interest Groups) and workshops in Europe.COPEARMS will actively cooperate with IMPRIMATUR (EP 20676), another "horizontal" project in the IPR domain aiming at a world-wide consensus-building process within the information industry. COPEARMS will participate in the business and legal SIGs and workshops held by IMPRIMATUR and in feeding into the electronic communication network that will be managed by IMPRIMATUR.The COPEARMS project is intended to last three years, starting towards the end of 1995. Its resources are based on the assumption of a coordination feasibility study of some eight vertical projects and actual coordinatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards a Mechanistic Account of Maintenance Goals' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

People need to invest tremendous effort and motivational resources to ensure that all the valuable things they have will be maintained, on both an individual level (e.g., family, households, health) and a societal level (e.g., public infrastructures, the natural environment). Nevertheless, little is known about people’s motivation to routinely maintain, nurture, and care for what they have. Psychological theory on motivation has focused on approach (e.g., starting a new relationship) and avoidance goals (e.g., avoiding separation), and left maintenance goals understudied . Addressing this gap in the literature, the current project introduces and tests a first general model of goal-directed maintenance. Instead of increasing gains or avoiding negative outcomes, maintenance goals are used to stabilize positive current states. When maintaining one’s existing relationship, for instance, people are not only avoiding separation; they are engaged in a set of acts that stabilizes their relationship in a manner that keeps acute threats like separation at bay. In a similar manner, environmentalism is not only the aspiration to slow down global warming (an avoidance goal), but also, and perhaps more importantly, the aspiration that humanity will learn to maintain a stable relationship with the biological world. The proposed empirical research will combine lab studies using implicit behavioral measures with experience sampling methods (ESM). The results of this research will lay the foundation for the study of maintenance goals as distinct from approach and avoidance goals, shedding light on processes involved in the most pressing socio-political issues of our time.


**Keywords:** Goal Regulation,  Motivation,  Maintenance,  Cybernetics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Pluggable Social Platform for Heritage Awareness and Participation'.

assistant: **Innovation**

Pluggable Social Platform for Heritage Awareness and Participation (PLUGGY) will support citizens in shaping cultural heritage and being shaped by it. PLUGGY will enable them to  share their local knowledge and everyday experience with others. The participation will include the contribution of cultural institutions and digital libraries, building extensive networks around a common interest in connecting past, present and future. PLUGGY frames its objectives around the Faro Convention, in line with new social paradigms which declare heritage as an asset and a responsibility for all, aiming to encompass greater democratic participative actions with concern for the local and the everyday. The PLUGGY Social Platform will facilitate a continuing process for creating, modifying and safeguarding heritage where citizens will be prosumers and maintainers of cultural activities. It will be web based, easily accessed and will allow the development of shared identity and differentiation. PLUGGY Social Platform’s users will curate stories using the PLUGGY Curatorial Tool. Content will be both crowdsourced and retrieved from digital collections, allowing users to create links between seemingly unrelated facts, events, people and digitized collections, leading to new approaches of presenting cultural resources, and new ways of experiencing them.PLUGGY will provide the necessary architecture for the creation of pluggable applications, allowing for beyond-the-project, not yet imagined ways to utilize the content on the social platform, while focusing on the design of the social interaction, helping to build new virtual heritage communities. The PLUGGY consortium spans 5 countries and includes 4 academic partners (ICCS, TUK, UMA, ICL), a total of 10 museums (PIOP, ESM) and 3 SMEs (CLIO,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Generic Open-end Simulation Environment for Minimally Invasive Cancer Treatment' in the context of a Seventh Framework call.

assistant: **Objectives**

The Go-Smart project will build a generic open-source software simulation environment for planning of image guided percutaneous Minimally Invasive Cancer Treatment (MICT). MICT includes radiofrequency ablation (RFA), cryoablation, microwave ablation (MW), transarterial chemoembolisation (TACE), brachytherapy (BT), and prospectively, irreversible electroporation (IRE). Beside of TACE each type of MICT uses needles that are inserted into the tumour tissue and the tissue is destroyed through heating, cooling, and application of an electric field or radiation. These treatments are often combined with TACE. The commonalities between the different procedures allow for the development of a generic, reusable, robust simulation environment with the relevant physics and physiology needed to correctly predict the result of MICT in terms of lesion size and shape. The environment will incorporate patient data and appropriate physiological models to simulate tissue response to heat, cooling, hypoxia, radiation, or electrical pulses. The models will account for multi-scale physiological dependencies between a full organ, its anatomical structures and tissue properties down to the cellular level. The software environment will be open-ended with extendable interfaces to allow clinicians to add further patient data collected before, during and after MICTs. This data will be used by the research community to refine the existing physiological tissue models thus transforming the environment into a user-driven growing info-structure. The Go-Smart environment will allow the Interventional Radiologists (IR) to select an optimal type of MICT by simulating the personalised result of the different treatments and medical protocols in patient specific conditions. Bringing different MICTs into a uni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structural studies of ligand-induced conformational changes in G protein-coupled receptors' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

G protein-coupled receptors (GPCRs) are eukaryotic seven-alpha-helix transmembrane proteins which are involved in extracellular signal transduction across the cellular membrane.  Aim of the proposed research is to structurally characterise ligand-induced conformational changes in GPCRs, to identify the number of alternative conformations the GPCR can adopt, and to engineer conformationally stabilised GPCR variants for subsequent biophysical and crystallographic studies. The research will focus on cannabinoid receptor type 2 and beta-1 adrenergic receptor. Both GPCRs can be expressed and purified from recombinant Escherichia coli as well as insect and mammalian cells.  Degree of ligand-induce conformational change will be determined for each amino acid residue by using a novel protein-engineering approach that combines alanine scanning mutagenesis and conformational phi-value analysis. Transition temperatures of denaturation for native and each mutated protein will be determined in presence and absence of particular ligand by high-throughput differential scanning fluorimetry or radioligand-binding assays.  These results will be used in engineering of GPCR mutants that are more stable and locked in the specific (eg, activated or inactive) conformational state. Ligand-binding to the stabilised mutants and their functionality will be monitored by fluorescence anisotropy titrations, as well as by radioactive assays using the corresponding G proteins. The stable and functional variants will be used in crystallisation trials. The diffraction data from the expected microcrystals will be collected on the microfocus X-ray beamline. Crystal structures will be determined by molecular replacement. The proposed research will give insights into the activation mechanisms of GPCRs. Deta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '1,3-propanediol - a versatile bulk chemical from renewable resources by novel biocatalysts and process strategies' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Recent development in the use of 1,3-propane idol (PD) as a monomer for novel polyesters and biodegradable plastics leads to a strong market need for an economical and sustainable production of this emerging bulk chemical, favourably by a biological route. Microorganisms from glycerol can naturally only produce PD. The present production volume and price of glycerol is prohibitive for the biological route to compete with the chemical rout. The objective of this proposal is thus to extend the substrate spectrum of microbial PD to cheaper and more abundant renewable resources (glucose, starch and sucrose). This will be achieved by designing new biological pathways and biocatalysts with genetic tools and by developing novel process configurations. The process will be demonstrated on an industrial scale. It will open new ways for a flexible utilisation of renewable resources for non-food value-added products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-speed, High-accuracy and Radiation-Hardened (Rad-Hard) Analog-to-Digital converter (ADC) in CMOS (Complementary Metal-Oxide Semiconductor) technology' (Rad-Hard).

assistant: **Concept**

The global market of high-qualified Analog-to-Digital and Digital-to-Analog converters (ADC and DAC respectively) is dominated by United States’ (US) firms, all of them subject to “International Traffic in Arms Regulations” (ITAR), and therefore to important restrictions in export and use in aerospace and defence applications outside the US. First European companies in the market hold marginal shares, and what is most concerning, they offer poor-performing products. The loss of competitiveness of these firms in the face of US’ competitors and European Union's (EU) technological dependence are evident. Facing this situation, the European Space Agency, the European Commission and the European Defence Agency agreed on a list of actions for strategic non-dependence in the area of critical space technologies, such us the development of high-performance and high-speed DAC-ADC based on EU technology.2SE is a start-up founded by experienced and high-qualified professionals coming from the research world and the electronics industry. This project is aimed at the feasibility assessment of a high-speed, high-accuracy and radiation-hardened (Rad-Hard) ADC in CMOS (Complementary Metal-Oxide Semiconductor) technology. It clearly outperforms all the competing products in terms of performance, features (including self-calibration tasks for autonomous systems), energy and cost efficiency due to its System-on-Chip design. This ADC is the result of a previous R&D project currently at a TRL6 and it is mainly targeted to specific applications developers/integrators and manufacturers of electronic equipment, whose main pain is the scarcity of a qualified offer. We will tackle space, aeronautics, automotive and medical segments, with EU as our first target, and international expansion through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Epigenetics and chromatin dynamics in gametes : using yeast spores and advanced proteomics'.

assistant: **Concept**

The field of epigenetics has been developing exponentially over the last decade. However, the organization of chromatin in gametes is still poorly understood. The role of this organization in fertilization and early embryonic development is largely unknown.For many years, I have been exploring different aspects of chromatin organization and dynamics during male gamete differentiation. The study of gametogenesis has proven to be technically challenging. My post-doctorate work, realized in the USA, demonstrated that a simple model, yeast sporulation, shares functional similarities with mammalian spermatogenesis. Taking advantage of this observation, I propose to deploy a new research program, EPIGAM2, using yeast sporulation as a powerful model for mammalian spermatogenesis.EPIGAM2 will be hosted by the group “Exploring the Dynamics of Proteomes”, directed by Jérôme Garin (Grenoble, France). The partnership between the candidate and the host laboratory has long-term interests, reinforcing cooperation between fundamental research and the development of new methodologies in proteomics. Indeed, EPIGAM2 combines multi-dimensional approaches using genetic, biochemical, and proteomic techniques. Project management has been carefully planned, and tasks, risk analyses, and milestones are presented. Support from this Marie Curie Action is vital for the launch of this research program, allowing the complete reintegration of the candidate and adequate development of his research program.To conclude, EPIGAM2 research program is based on a unique combination of (i) an innovative biological question, with potential implications for fertility care, cancer biology, and regenerative medicine, (ii) an original biological model, yeast spores, validated by several high profile publications,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of integrated pest management techniques for the control of ascochyta blight of chickpea' to be submitted under Fifth Framework.

assistant: **Abstract**

Integrated Pest Management (IPM) procedures based on fundamental data obtained in the project will be developed for the control of blight of chickpea caused by Ascochyta rabiei. Image analyses and their conversion to a hand-held key will be used to score symptoms, identify resistant genotypes and monitor control measures. Control measures will consist of adjustment of planting date to promote disease escape, reduction of inoculums by sanitation, seed dressings and spray programmes (designed to be least harmful to the environment), breeding for resistance (aided by genetic markers and selection for insensitivity tophytotoxins produced by the pathogen) and the amelioration of symptoms with safeness. These data will be assembled into an Integrated Pest Management system for control of blight of chickpea and disseminated to farmers by workshops and pamphlets in local languages and by publications in scientific journals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improving the economic feasibility of the biorefinery through catalysis engineering: enhancing the catalyst performance and optimizing valuable product yields' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Catalytic pyrolysis of biomass is a process for the conversion of lignocellulosic biomass to a liquid product that has potential to be utilized as a fuel, a source of renewable chemicals and as an alternative to crude oil for upgrading to transportation fuels. ZSM-5 zeolite is the most studied catalyst for this process due to its acidity and shape-selectivity, which favour the conversion of biomass oxygenates to valuable aromatic hydrocarbons and limit the formation of coke. Among the shortcomings of the ZSM-5 zeolite is the small size of its pores; these small pores do not allow the large molecules in the pyrolysis vapours to access the active acid sites. Secondly, its sensitivity to biomass metals leads to poisoning and deterioration of its selectivity. Coupled with the high cost of the ZSM-5, the later leads to significant operating costs that arise from the necessity to replace the deactivated catalyst with fresh material at high rates.The objective of this proposal is to investigate and improve on the economics of the process by reduction of catalyst-related operating costs and optimization of catalyst selectivity towards desirable products. This is going to be achieved through utilization of microporous zeolites modified with mesoporosity. Mixed results have been reported with such zeolites in the past. To address this, a suitable experimental procedure will be developed for the systematic study of mesoporosity through assessment of multiple aspects of catalyst performance, such as activity, selectivity, coke suppression and deoxygenation. Increased activity and selectivity is expected to result from increased accessibility of larger molecules to the zeolite acid sites. In order to address the short lifetime of the catalyst, the mechanism of poisoning from biomass