RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mitochondrial regulation of structural and functional plasticity within adult neurogenic circuits' (MITOPLASTICITY) targeting Horizon 2020.

assistant: **Abstract**

A fundamental question in neuroscience is to reveal the energy constrains governing the plasticity of brain circuits. Mitochondrial energy metabolism is increasingly recognized for regulating the activity and integrity of existing synaptic terminals, however it is unclear how changes in mitochondrial function are coupled with the generation of new neurons and the ensuing circuit remodelling, e.g. in response to experience or disease. We have recently shown that a regionalized restructuring of the mitochondrial network in astrocytes upon cortical injury underlies their ability to enter a state of reactivity and sustain cellular energy metabolism, suggesting that local changes in mitochondrial network architecture govern cellular adaptations in register with local metabolic demand. Here, I focus on the adult hippocampal circuitry and its almost unique structural plasticity to broaden this fundamental concept and evaluate whether local mitochondrial remodelling orchestrates the metabolic changes underlying the directed genesis of new neurons and their evolving connectivity in face of experience. First, we will utilize state-of-the-art imaging and genetic techniques to investigate the precise role of mitochondria in regulating adult neural stem cells (NSCs) quiescence, mode of division and neurogenic potential in response to experience. This will set the stage for examining whether state-specific energy metabolism programs regulate the fate plasticity of adult NSCs, as following their directed differentiation towards distinct lineages in vivo (Aim I). We will then elucidate whether mitochondria contribute to mechanisms of metabolic and synaptic competition in new neurons, in particular to their critical period of heightened structural and functional synaptic plasticity (Aim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Building European Nuclear Competence through continuous Advanced and Structured Education and Training Actions' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Nuclear power and non-power technologies are technically very complex facilities that operate in the increasingly challenging regulatory framework and market conditions. Development, construction, operation, decommissioning, waste management and oversight of these facilities require personnel with excellent education, skills and motivation: nuclear specialists, that are equipped to work in multidisciplinary, multicultural and competitive environments. ENEN# stands for the largest and most integrative nuclear Education and Training (E&T) efforts up to date. Attraction of excellent new talents followed by outstanding development through E&, cross-cultural and cross-disciplinary activities are the overarching objectives. Excellent workforce should remain the basic enabler of safe long-term operation of existing and development of advanced facilities. A detailed insight into the EU supply and demand of nuclear human resources for power and non-power applications will be developed. This will include industries, academia, technical safety organizations and regulators. Higher number of nuclear talents will be achieved through dedicated career related events and competitions for high school pupils and teachers, students (BSc, MSC, PhD), postdocs and lifelong learners. A strong mobility program will support over 100 person-years of nuclear career enhancing experience to about 1.000 learners with over 2,5 million EUR. Cross-border and cross-disciplinary mobility within and beyond EU will be promoted in cooperation with JRC, OECD/NEA and partners from USA, China, Korea and Japan. A single hub will be established to provide information on available educational, training and job opportunities. Appropriate connections with the complementary NRT-12 project facilitating access to resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SpectraHow. Smart Raman sensor to speed up biopharma manufacture' (SpectraHow) targeting Horizon 2020.

assistant: **Abstract**

Today, biopharmaceuticals generate global revenues of €145 billion, representing about 20% of the pharma market. The growth rate of biopharma, 8%, currently doubles that of conventional pharma. However,  biopharma companies are facing an increased pressure for cheaper process development, faster time to market as well as more consistent production (reducing failure). Raman spectroscopy is a promising technology to improve bio processing and manufacture. Nevertheless, the corresponding data analysis of the complex spectra in biopharma is more challenging that conventional pharma,  taking 2-5 months in order to acquire enough data and train a reliable predictive model. Founded in 2017, DataHow is a spin-off from the ETH Zürich, with the aim to accelerate biopharmaceutical process development and reduce risks in production through advanced algorithm-enabled digital solutions; SpectraHow is our scalable software based on advanced machine learning techniques, capable of accurately handling the large amounts of data generated, to automatically quantify the process dynamics and translate the information into direct decision support. Our algorithmic toolbox at TRL6 has been already tested in operational environment for different processes with several pharma companies, with a precision of up to 35% more accurate compared to commercial tools, and a smaller effort due to our automated calibration procedure. Next steps to take forward SpectraHow to commercialization are: improve usability with a Graphical User Interface, fine-tune our models and algorithms to further automate analysis, and show compatibility of our solution with third-party software tools to expand its functionality from R&D to production and to other spectroscopy techniques. In the booming Raman for pharma market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Business Environment of Biometrics involved in electronic commerce' (BEE) under Fifth Framework.

assistant: **Objectives**

BEE will investigate the elements that impede the business environment involved in electronic commerce from using biometric technologies for its security. BEE aims at identifying barriers, bottlenecks and proposing scenarios for creating a secure e-commerce business environment favourable to biometric technologies.The BEE project will also identify the social and economic impacts of using biometric technologies in the security of electronic commerce in the next decade, and it will quantify and demonstrate evolution scenarios, evaluating the social and economic impacts of the biometrics technologies and electronic commerce services on work and business.BEE is separated into two phases:During the first phase of BEE, we developed a desk research report, capturing the present situation in the biometrics field. This report was the outcome of an extensive research on technological, legal, standardization, business and societal aspects of biometrics. We also created two questionnaires concerning these aspects and invited players from all sectors (from experts/manufacturers to common users) to answer them. Processing the answers we created reports using statistical models, capturing the present situation as described by survey. We organized a meeting, inviting experts in biometrics and constructed scenarios, forecasting the future of biometrics, in order to identify barriers and threats that would impede there wide spread. Finally we conducted a benchmark of legal, societal, standardization and business issues in Europe versus the US and Japan.In the second phase of the project, business and marketing aspects of biometrics are being studied. A report will be developed on marketing barriers arising from technical, legal, and standardization perspective and we will draw marketing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development and Implementation of the Data Acquisition and Back-End Readout System of the TileCal Detector of the ATLAS Experiment' under Sixth Framework.

assistant: **Concept**

The ATLAS experiment is a large detector for the study of high-energy proton-proton collisions at the Large Hadron Collider (LHC), presently under construction at the European Organization for Nuclear Research CERN, and scheduled to start operation in 2007. At the LHC collisions are produced at a rate of 40 MHz. Real time computation of some fundamental magnitudes with data flows of 200 Gbytes/s (e.g. the energy deposition) must be performed to provide much precise information to the further steps of the on -line event selection.The present proposal aims at a major contribution to the development, and implementation of the back-end and read-out system of the Tile Hadronic Calorimeter of the ATLAS detector. The conclusion of the work will be the commissioning of the entire back-end readout system (9000 readout channels, 70000 MIPs) of the Tile Calorimeter and its validation with early LHC data. The design of the different components is now in the pre-production stage. However, investigation of key elements is mandatory for the successful completion of the project and the full exploitation of the detector discovery potential.For the next two years, the full integration of the readout system must be performed, and the energy and collision time computation must be implemented and validated taking into account the high rate environment with maximum allowed latencies of 10 micro seconds. The applicant will play a leading role in the commissioning and integration of the TileCal readout system, its validation with early data, and the development of the on-line algorithms for energy and time computation.This project will provide him a challenging training in high rate data acquisition systems, and a superb basis for the exploitation of the ATLAS detector. Working in an internati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Non-thermal process to replace use of sulphites and other chemical preservatives in European wines to meet new European Directive' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

We are a partnership of EU SMEs that has identified a promising non-thermal process that can extend wine shelf life while avoiding the use of chemical preservatives and keeping high wine quality. Pressure Change Technology PCT is a low cost process with minimum energy use, that has potential with further development and validation to be of significant commercial benefit to wine producers by providing them an alternative to align to current EC regulations that dramatically reduced the use sulphur dioxide in wines due to the health concerns. With over 1,5 Million wine holdings in Europe, we identified a potential market for this system of at least 1% of wine holdings in Europe (150,000 PCT units) This project we will extend prior R&D. PCT is a novel non-thermal technique that involves charging product with pressure and an inert gas and then rapidly releasing the pressure; the sudden pressure release causes microbial cell walls to rupture, inactivating microorganisms. It has been demonstrated on a small pilot scale batch process; in this project we will scientifically validate the process, developing and scaling it up into a continuous in-line pre-industrial demonstrator testing it with wine but to also enable application to other liquid foods. Objectives: Repeated validation of the process to reduce microbial loading in wine by at least log10 5 and protect wine from chemical and biological oxidation./Enhanced organoleptic quality (aroma and taste) of wine when compared to “sulphited wine” wines when assed by a trained taste panel. /Pilot scale demonstration of our PCT system capable of being integrated into a commercial winemaking process line, at flexible design for optional application at various processing stages, with a throughput of 120 L/h / Full HACCP and GMP compl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A scientifically proven Microbiome immunotherapy for the treatment of colorectal cancer' (Oncarin) under Horizon 2020.

assistant: **Objectives**

Following 30 years of research, ZMD has developed ONCARIN; an immunotherapy treatment for the treatment and to boostto immune system of patients with colorectal cancer. The treatment consists of special developed capsules containing alyophilized mixture of live bacteria (colon flora) with a high oncolytic activity. ONCARIN has the unique ability to both inducecancer cell destruction and activate the immune system. Furthermore the technology allows for an easy synthesis andmanufacture enabling the commercialization of a cost-effective product (90% lower than competitor’s prices). No otheroncologic drug, currently marketed, is able to address therapy effectiveness, absence of side effects, and healthcare costsavings.In addition, Oncarin can be easily implemented for a wide range of immune conditions including cancer, Crohn’sdisease, colities and immune system disorders after long-term treatment with antibiotics. This will improve patient outcomesand greatly reduce healthcare costs. Moreover, ONCARIN costs 90% less than current solutions. ZMD will exclusivelylicense the further development and commercialization of ONCARIN to a pharmaceutical company. Oncarin now has a TRL6, since successfully completing proof of concept in animal models. The next step to advance TRL is to conduct a phase Itrial in order to demonstrate safety and pharmaceutics of Oncarin. Z.M.D Medical Ltd is part of ZMD group ,which includesZMD Diagnostics Ltd. ZMD Medical develops and commercializes therapeutic remedies to cure cancer of all types using theimmune system- first focus- colorectal cancer. Z.M.D Medical has set a goal to produce the drug to rehabilitate distressedcolon microflora in order to eliminate cancer from patients’ immune systems. Barak Zigdon, an MBA with significantentrepreneurial e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'NUMERICAL METHODS AND TOOLS FOR KEY EXASCALE COMPUTING CHALLENGES IN ENGINEERING AND APPLIED SCIENCES' (NUMEXAS) targeting Seventh Framework.

assistant: **Abstract**

Exaflop computing will make a considerable impact on several areas of engineering and applied sciences, where current high-end computing capabilities are deemed grossly insufficient. The overall aim of the NUMEXAS project is to develop, implement and validate the next generation of numerical methods to be run under exascale computing architectures. This will be done by implementing a new paradigm for the development of advanced numerical methods to really exploit the intrinsic capabilities of the future exascale computing infrastructures.The project covers RTD activities along the complete simulation pipeline: parallel pre-processing and grid generation, new numerical methods for parallel structured/unstructured multidisciplinary field solvers of high order, optimum design parallel solvers considering uncertainties and parallel in-solver visualization and feature extraction. The new numerical methods and software will be validated for a selected number of exascale size problems in engineering and applied sciences in state-of-the-art high performance computing platforms.The main outcome of NUMEXAS will be a new set of numerical methods and codes that will allow industry, government and academia to solve exascale-class problems in engineering and applied sciences in the next generation of exaflop computers with the efficiency and ease of use as today's state-of-the-art codes.The consortium has a well-balanced distribution of institutions specialized in the development of numerical methods to solve grand challenge engineering and scientific problems (CIMNE, LUH-IKM and NTUA) and institutions hosting HPC facilities and supercomputing infrastructures (CESCA and LUH-HLRN). The partnership is completed with QUANTECH, an SME specialized in the development and marketing of simul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhancing and Re-Purposing TV Content for Trans-Vector Engagement' (ReTV).

assistant: **Concept**

Re-purposing and re-using digital content is of vital importance to broadcasters and other stakeholders in European media value chains. High initial production or acquisition costs need to be recouped, but the abundance of online channels creates a thin viewer market for original content, especially on niche topics. Live and on-demand viewing is now spread across Smart TVs, Web and mobile applications, social media and other emerging platforms (to be referred to as “vectors”). This introduces an important challenge: How should broadcasters decide when, in what form and on which vector(s) to deliver which content? We propose the Trans-Vector Platform (TVP) to address this challenge and help media companies gain a competitive advantage through guided content re-purposing and re-publication, on the fly and across vectors. The TVP requires novel methods to extract metadata, predict patterns in the topic-vector-audience matrix, and apply these patterns to enhance and re-purpose content - across vectors and according to predicted audience interests. Thus, ReTV will advance the state of the art in video analysis, video augmentation and annotation, content and audience metrics, prediction and recommendation models, visual analytics. The results of this extensive research will be tested and validated together with a regional public broadcaster (RBB), a national TV archive (NISV) and an OTT TV distributor operating in multiple EU markets (Zattoo). ReTV will offer them a better match between content and viewers across vectors, time and five EU languages (English, German, French, Spanish, Dutch). Impact will be measured via cross-vector deployment and viewer engagement. Automated re-purposing and more accurate targeting in terms of relevance and appropriate representation, tailored
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhanced INterfaces and train categories FOR dynamic compatibility assessment of EUropean railway BRIDGEs' (InBridge4EU) targeting Horizon Europe.

assistant: **Abstract**

The shift to more sustainable mobility systems is one of the major priorities to accomplish the goals established by the European Green Deal to make Europe the first climate neutral continent by 2050. Railways plays a crucial role in this regard, but it is essential to enhance the current resilience and capacity of the network, in particular from lifeline structures, such as bridges.Within this regard, several open points affecting the current INF TSI  and described in the ERA Technical Note are yet to be closed, namely those related to the Dynamic Train Categories previously specified in EN15228:2015 and the limits of validity of the static compatibility checks currently stipulated EN15228:2021, the accuracy of the current dynamic amplification factors and damping values for railway bridges proposed in EN1991 2 (2003) and the validity of the deck acceleration limits imposed by EN1990-Annex A2 (2005) in both new and existing bridges.InBridge4EU aims to answer these points through the formulation of an enhanced and harmonized method to assess the European dynamic interface between railway bridges and rolling stock. The outcomes of this project will provide solid background to the guidance being drafted within the CEN/TC250/SC1 special group DIBRST for dynamics of bridges. Finally, as a consequence, the economic outcomes of changing any of the aforementioned criteria/parameters/methodologies in the current European railway bridge landscape will be carefully assessed. All the research carried out in InBridge4EU will converge on recommendations to ERA and CEN for revising and updating the current version of the TSIs and Eurocodes. Advanced numerical modelling and dynamic analyses of both bridge and railway vehicles, together with the development of extensive databases of br