RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Snail at the crossroad of the epithelial to mesenchymal transitions: Implications in embryonic development and tumour progression' under Sixth Framework.

assistant: **Concept**

The Snail gene family of transcription factors plays important roles during embryonic development in processes that imply profound cell movements. These functions are essentially mediated by the triggering of the epithelial-mesenchymal transition (EMT), a phenotypic change that renders epithelial cells migratory and invasive. EMT is also a well-known process that occurs in the acquisition of invasive and migratory properties during tumour progression. Indeed, Snail genes have been coopted for the acquisition of malignant properties in epithelial tumours. It is well known that EMT can be triggered by different growth factors, including FGF, TGF-beta, HGF, etc. and recent results from several laboratories including the host lab indicate that all of them induce Snail expression concomitant with the induction of EMT. Thus, Snail may be a point of convergence of the signalling pathways triggered by these growth factors, and thus, located at the crossroads of the EMT.Interestingly, unpublished data from the host l ab indicate that Snail also protects from cell death, leading to the idea that the process of EMT may be associated to cell survival through Snail. This link is of high interest due to the fact that tumour cells are indeed more resistant to cell death than their normal counterparts. The aim of my postdoctoral period in the team of Angela Nieto is to check the hypothesis of Snail being a central point during the triggering of EMT both in physiology and pathology. I will take advantage of my previous knowledge in Cell Biology and in the culture of cells and organs and particularly, of my background in the analysis of cell death both in vitro and in vivo. In addition to analyse the effects of growth factors on epithelial cells regarding the induction of EMT and Snail,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on '3D-PRintable glass-based Electrolytes for all-Solid-State lithium batteries'.

assistant: **Innovation**

The main goal of the 3D-PRESS project is to advance in the 3D printing concepts for safer, cheaper and customizable all-solid state Li-ion batteries (LIB). More specifically, the project is focused on the design, production, characterization and testing of 3D printed NASICON-type glass-based electrolytes for 3D printed batteries. In 3D-PRESS, glass-based compositions will be designed and synthesized in order to obtain printable glass-based electrolytes with superior conductivity and functional properties. The produced glasses will be thermally and electrochemically characterized in order to investigate their sinter-crystallization behaviour (tailoring suitable sintering treatments) and electrochemical performances. The most promising electrolyte compositions will be selected to be printed in free-form robust self-standing structures in order to obtain 3D batteries with high active area (allowing high specific energy and power per unit volume).3D-PRESS represents a cutting edge multidisciplinary approach for the development of reliable and customizable all-solid state 3D LIBs, especially interesting for micro-power applications such as the ones for Internet of Things (IoT). The project will provide a new family of printable materials increasing the short list of available compositions, especially solid electrolytes, opening the door to the development of a new generation of fully printable all-solid state 3D LIBs.A high impact on the future career of the candidate is expected by complementing his current background with new skills in one of the more relevant Key Enabling Technologies (KETs), 3D-printing, applied to the crucial field of the Energy Storage. Moreover, the host institute will offer unique opportunities to re-enforce the technology transfer competences of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Do plants cooperate in reproduction? The effect of sharing pollination services on plant reproductive strategies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Although social interactions in non-sentient beings such as plants might seem unlikely, there are good reasons to expect them to be important. Because plant populations are very often strongly genetically structured, with neighbouring plants frequently being relatives, their behaviour is expected to have been shaped by natural selection within this social context. Plants interact very strongly with their neighbours, and there is an increasing body of evidence showing kin recognition and cooperation with relatives, e.g., warning against herbivore attacks and reducing resource competition. However, little is known about how plants behave in a social context in terms of their reproductive strategies. This is surprising, because reproduction is a key life-history trait defining gene transfer, and thus is closely linked to fitness and to the evolutionary potential that will eventually determine the functioning and dynamics of plant populations and communities.Neighbouring plants commonly facilitate pollination. Therefore, the resources invested in floral attractive structures for one individual can positively impact individual fitness, but also the fitness of neighbours, increasing both individual and group benefits. Thus, natural selection should be expected to favour plastic adjustments of the resources allocated to pollinator attraction to the surrounding social environment. I will test this hypothesis, assessing how different social environments might influence optimal allocation strategies and the effect this will have on mating patterns and plant fitness. To address this objective, I will use an interdisciplinary approach that combines theoretical modelling and empirical testing, bringing tools from the sociological sciences to the study plant ecology and evolution. My
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Somatic suicide gene therapy for cancer' (1994-1998).

assistant: **Concept**

The development of new viral vectors will focus on more efficient transduction and expression and on cell-type specific expression. Recombinant vectors containing mutant forms of herpes simplex thymidine kinase that are less toxic will be constructed and tested in vitro in combination with ganciclovir and novel antiherpetic nucleoside analogues. Vectors expressing the E. coli DeoD gene will be engineered and tested in combination with 6-methyl-purine-2'-deoxynucleoside. After studying the therapeutic index and bystander effect of these novel suicide gene/prodrug combinations in vitro, application in selected animal models will take place. Different routes of non-traumatic and more efficient viral vector delivery will be developed including systemic administration, convection enhanced intratumoral delivery and retrovirus producing cells embedded in biopolymers. These methods will be tested partly in vitro but mostly in a variety of animal models. In vivo imaging of the efficiency of suicide gene transfer is based on selective accumulation of some nucleoside analogues (including 5-iodo-2'-fluoro-2'-deoxy-arabinofuranosyluracil [FIAU]), after phosphorylation by herpes simplex thymidine kinase. Radiolabeled (14C, 125I, 18F) nucleoside analogues (FIAU) will first be tested in vitro using autoradiography and subsequently in vivo using autoradiography and SPECT/PET imaging. The bystander effect will be studied in vitro (above) and in vivo in brain tumour and multiple myeloma, Iymphoma and seminoma models. Modulation of the bystander effect will be attempted in vitro and in the multiple myeloma model by upregulation of connexins, molecules involved in gapjunction formation. The anti-tumor immune response elicited by suicide gene/prodrug treatment will be analyzed and modulated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ISIS Target Station 2' (2002-2006).

assistant: **Innovation**

ISIS Target Station 2 is a major upgrade of the ISIS spallation neutron source, offering the possibility for 18 new neutron scattering instruments with significantly improved and optimized performance, the emphasis being on research in soft condensed mat ter, bio-molecular sciences and advanced materials. This represents a significant increase in both the capacity and capability for research using neutron scattering in Europe. This project will enable the first seven instruments to be developed as a Euro pean collaboration. This will broaden the European knowledge base in spallation source instrumentation and provide enhanced access for European users to the full range of scientific research opportunities available at ISIS. The project has three key obje ctives:  - Construction, commissioning and initial operation of the ISIS Second Target Station including  buildings and services, extracted proton beam, target station and moderators.  - Construction and commissioning of seven instruments on ISIS Target Station 2.  - Exploitation of the ISIS Target Station 2 in the ISIS user programme. The ISIS Target Station 2 project is a key part of a strategy to maintain a strong level of internationally leading neutron scattering capability in Europe, in line with the recommendations of the OECD Megascience forum (1998) and European Strategic Forum on Research Infrastructures (2002). The scientific and business cases for TS2 are so strong that the UK government is investing more than 150M? in the projec t.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Towards a molecular-level understanding of heterogeneous ice nucleation'.

assistant: **Objectives**

Ice formation is one of the most common phase transitions on Earth. It is relevant to an enormous variety of phenomena such as weathering, cloud formation, airline safety, agriculture, and energy. However, despite having been studied since antiquity, our molecular level understanding of ice formation is largely incomplete. In particular, almost all ice formation in nature is aided by impurities or the surfaces of foreign materials, yet how surfaces act to facilitate ice formation (heterogeneous ice nucleation) is unclear. Given the ubiquity of ice nucleation, this is arguably one of the biggest unsolved problems in the physical sciences.Experiment provides insight into crystal nucleation and growth, but most nucleation events happen too quickly and involve too few particles to be rationalised purely by experiment. As a result, computer simulations play an important role and I believe we are now on the verge of using simulation to bring about major breakthroughs in understanding ice formation. Specifically, in this project we aim to perform the first full-on attack on heterogeneous ice nucleation so as to elucidate how the physiochemical properties of materials control their ability to nucleate ice. We will focus on nucleation on solid inorganic substrates and our approach will be to couple systematic studies on model systems with in-depth explorations of more realistic (and experimentally realisable) surfaces. We will improve existing computer simulation methods and develop new ones for accurate large- scale simulations of phase transitions in complex heterogeneous environments. In so doing we will help to make simulations of ice nucleation more routine, enabling us to establish what makes a good ice nucleating agent. The results from this multi-disciplinary project wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Validation of Lunar Water Extraction and Purification Technologies for In-Situ Propellant and Consumables Production' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Sustainable space exploration requires the development of In-Situ Resource Utilization (ISRU) technologies, which encompass all processes that utilize local resources to generate useful products for robotic and human exploration. Among the available resources, water is the most versatile and most needed in space exploration. Water can be easily stored and directly used as consumable for astronauts or electrolyzed to hydrogen and oxygen, a very effective rocket propellant combination. LUWEX aims to develop, integrate and validate lunar water extraction and purification technologies for in-situ propellant and consumables production for future space exploration missions. The consortium will develop key technologies for an in-situ raw water process chain, which include an innovative water extraction prototype, water purification technologies and water quality monitoring for application in a future European-led space exploration mission. An integrated test setup will be built to validate the operational capabilities of the technologies and also of the whole process chain. This setup will deliver a relatively realistic environment analogue to the lunar surface and will use a lunar dust-ice simulant to provide proper validation conditions to raise the TRL of all subsystems and the whole process chain to level 4. The interdisciplinary nature of LUWEX combines research and innovation in space engineering, space science and exploration, geophysics and terrestrial water systems. Large space industry (Thales Alenia Space), research organizations (DLR), SME (Liquifer Systems Group, Scanway) and academia (Technische Universität Braunschweig, Wroclaw University of Science and Technology) from four European countries (Germany, Italy, Austria, Poland) join forces in a unique consortium
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development'.

assistant: **Innovation**

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Expressions of Interest (EoI) prior to this application and to which interested parties could respond. In total, 115 EoIs were received  and ranked by the TBVI Steering Committee using proposed H2020 evaluation criteria. This led to the prioritisation of 52 R&D approaches included in this proposal. TBVAC2020 aims to innovate and diversify the current TB vaccine and biomarker pipeline while at the same time applying portfolio management using gating and priority setting criteria to select as early as possible the most promising TB vaccine candidates, and accelerate their development. TBVAC2020 proposes to achieve this by combining creative “bottom-up” approaches for vaccine discovery (WP1), new preclinical models addressing clinical challenges (WP2) and identification and characterisation of correlates of protection (WP5) with a directive “top-down” portfolio management approach aiming to select the most promising TB vaccine candidates by their comparative evaluation using objective gating and priority setting criteria (WP6) and by supporting direct, head-to head or comparative preclinical and early clinical evaluation (WP3, WP4). This approach will both innovate and diversify the existing TB vaccine and biomarker pipeline as well as accelerate development of most promising TB vaccine candidates through early development stages. The proposed approach and involvement of many internation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Uncovering determinants of animal personalities using movement data' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The field of animal personality links consistent behavioral variation among individuals to simultaneous differences in life history strategies and fitness. The relative contribution of genetics and developmental processes, such as maternal or individual learning on personality are however poorly understood. The proposal suggests to link animal personality to the field of movement ecology as a new source of data for behavioral studies that allows access to behavioral long term data on long lived wildlife species that was formerly unavailable. Using a unique dataset of multigenerational GPS-relocations, genetic, and dietary data of European brown bears, this research proposal will quantify 1) which portion of personality is determined by genetics and which part by maternal learning, 2) to what degree an animals personality is stable throughout life, and based on that 3) whether behavioral traits measured at earlier stages in life can be used to predict behavior later in life. This will be particularly useful to develop a predictive model of how environmental conditions, maternal behavior and relatedness determine the movement and dispersal behavior of young bears. These behaviors are directly linked with resilience to anthropogenic disturbances as well as population connectivity. In light of expanding carnivore populations across Europe, understanding which individuals are most likely to disperse through anthropogenic landscapes will be critical to successfully mitigate conflicts. The ER will use the latest advances in the field of movement ecology to quantify individual differences in movement strategies among bears. The ER’s experience with the study system, in combination with the supervisors excellence in the field of movement ecology, and the high relevance of the to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Local Democratic Governance towards Equality: Implementation of Gender+ Equality Policies in times of Anti-Gender and Democratic Backsliding' to be submitted under Horizon Europe.

assistant: **Abstract**

LODGE studies local responses to one of the crucial challenges of contemporary European societies: preserving mechanisms designed to protect gender equality and democratic inclusion in an increasingly polarized climate. The project examines localism, a form of governance that privileges local institutions as key sites of civic engagement and citizen control over public services. Specifically, LODGE tests the scholarly agreement that localism is a particularly fertile terrain for the design and implementation of gender+ equality and democratic inclusion policies, because of the capacity of local administrations to reorganize political priorities and redistribute power and resources more equitably. The project proposes an empirical study to measure the implementation of the legislative agenda of Barcelona and Madrid city councils during 2015-2019, two local governments in Spain that professed localism and designed pioneering feminist politics. The project will deliver: 1) an analysis of gender+ equality and democratic inclusion policies that are distinctive of localist agendas; and 2) an analysis of the obstacles and opportunities to implement such policies, with a specific focus on the discursive negotiation of policy meanings, and the impact of key actors and organizational structures in the success of policy implementation. LODGE will conduct content and frame analysis of policy documents, in-depth interviews with municipal technical personnel, participant observation in technical meetings, two workshops with policy experts, and will produce a technical report. The project will contribute to develop the increasingly relevant concept of localism from a gender+ equality perspective, advance the field of implementation studies of gender equality policies, empirically docu