RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Elucidation of forskolin biosynthetic pathway in Coleus forskohlii' (BioFors).

assistant: **Concept**

Coleus forskholii is a shrub of the Lamiaceae family, used as an ayurverdic medicinal plant. The roots of this plant are producing a labdane type diterpene named forskolin, known mainly for its pharmaceutical activity for protection against heart failure problems, hypertension treatment as it acts as vasodilator, anti-inflammatory properties and its effects in treating respiratory track problems. The medicinal activities of forskolin are due to its ability to activate the enzyme adenylyl cyclase and therefore to increase the levels of cyclic AMP (cAMP) in the cells. Today it is known that forskolin is produced exclusively by the roots of the species Coleus forskohlii, together with a plethora of different diterpenes, hence its availability is restricted. Thus, the aim of this research proposal is to set the base for the elucidation of the coleus diterpenoids pathways and second to generate production platforms for the controlled biotechnological synthesis of the metabolites of interest. This will be achieved using state of the art technologies and methodologies. New generation sequencing will be used for deep sequencing of the root bark transcriptome (the specialized root tissue responsible for the synthesis and accumulation of forskolin). Genes involved in forskolin and other diterpenoids production will be identified from the generated data bases, will be cloned and functionally characterized for identifying their exact role in the pathways. Upon characterization, selected genes will be expressed in the microbe yeast and/or in the moss Physcomitrella (a novel plant based terpenoid production platform, exhibiting numerous advantages in comparison with microbial systems) for the sustainable production of pure bioactive diterpenoids, which will enable the studies of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Best Engineering Training in Electric, Lightweight and Quiet Driving' in the context of a Seventh Framework call.

assistant: **Objectives**

Engineering for future mobility must be inspired by ecology and economy to enable green and silent vehicles. Current university based education is focusing on classical fields like mechanical engineering on one side with some aspects of Noise, Vibration & Harshness (NVH) and LightWeight Design (LWD) or like electrical engineering covering aspects of “Electrification” & “Hybridisation” on the other side.The proposed eLiQuiD project (Best Engineering Training in Electric, Lightweight and Quiet Driving) aims to bring together early stage researchers and experienced specialists from key players in academia and industry across Europe covering NVH, LWD and H/E disciplines to form a broad range of backgrounds. Recent research underlines the strong interaction and shows the often conflicting demands of these 3 topics.Consequently, an optimum for future vehicle development requires an interdisciplinary education in this triangle of topics. eLiQuiD’s focus is to motivate and encourage early stage researchers for scientific work in the new interdisciplinary research fields NVH+LWD, LDW+H/E and H/E+NVH. The fellows will be trained and supported in their phase of doctoral thesis to find innovative PhD topics as well as to receive specific education in theoretical and practical trainings. The education will comprise existing lectures in the partner network as well as training specifically developed for the interdisciplinary needs.eLiQuiD is formed by two participating hosts, combining leading education and research institutions as well as an associated partner, well established in European automotive R&D, to assist in the dissemination and outreach or eLiQuiD results. Thus the engineers will participate in both the scientific research work and the practical application of new methods
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Targeting eicosanoid metabolism to overcome tumor immunosuppression'.

assistant: **Objectives**

The field of cancer immunotherapy has witnessed exciting therapeutic advances in the last decade, but still a large fraction of patients is not responsive and several cancer types are refractory to this therapy. The presence of a strongly immunosuppressive environment is a likely explanation for the suboptimal efficacy of immunotherapy. One of the most abundant and immune suppressive population in the tumor microenvironment (TME) is represented by tumor-associated macrophages (TAMs). Therefore, several strategies that sculpt the TAM phenotype away from their immunosuppressive state are expected to become the next generation immunotherapies. Supported by the ERC consolidator grant ImmunoFit, we recently unveiled that the metabolic editing of the TME via the pharmacological and genetic inhibition of HPGDS in macrophages (an enzyme involved in the production of prostaglandin D2 from arachidonic acid), represents a novel therapeutic strategy to sculpt TAMs away from their immunosuppressive state, increase infiltration and fitness of CD8+ T cells and NK cells, and promote tumor vessel normalization. This change in the TME upon HPGDS inhibition overcomes resistance to current immunotherapeutic regimens in melanoma and other cancer indications. This proposal aims to de-risk HPGDS targeting by delivering a lead compound with proven efficacy in several preclinical models. The deliverables of this project will open-up a window of opportunities in immune-oncology and lead to novel combination therapies by increasing the potency of the current therapeutic approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ERA Chair in Maritime Cyber Security at Tallinn University of Technology' (MariCybERA) targeting Horizon 2020.

assistant: **Abstract**

The European and international maritime industries face serious threats from cybercriminals. Shipping companies and ports have begun falling prey to computer viruses (AP Moller-Maersk in August 2017, COSCO Shipping Lines in July 2018, the ports of Barcelona and San Diego in September 2018, etc.) IT hackers are colluding with drug traffickers to import illegal drugs such as cocaine and heroin (Port of Amsterdam, 2011-2013), and shipping vessels have become vulnerable to GPS jamming and spoofing attacks (Black Sea in June 2017, Mediterranean Sea in August 2019).  Tallinn University of Technology (TalTech) is part of an Estonian ecosystem of cyber security and maritime actors – NATO Cooperative Cyber Defence Centre of Excellence, several Estonian maritime associations, research institutes and private companies – with the collective know-how to tackle maritime cyber security threats. Estonia has first-hand experience of state-sponsored cyber warfare (April 2007) and is renowned for its IT innovation (Skype, 2003), e-governance (e-Voting since 2005), e-residency (2014), and cyber savvy population (95% of income tax returns filed online).  To unite Estonia’s capabilities in a focused and integrated manner, TalTech will recruit an outstanding researcher and research coordinator to be the ERA Chair Holder (together with a team of experienced researchers) who will head a new, multidisciplinary Centre for Maritime Cyber Security at TalTech. Plus, a Research Administration Manager will be recruited to support TalTech’s Research Administration Office.  Reflecting important structural change, the Centre for Maritime Cyber Security will be created by integrating research capabilities from TalTech’s Estonian Maritime Academy and TalTech’s Centre for Digital Forensics and Cyber Securit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A New Approach to Electrocatalytic CO2 Reduction Based on Supramolecular, Dinucleating Catalysts""' (CO2REDUCTDINUCLEAT).

assistant: **Concept**

In this project it is wanted to synthesize a new family of homobimetallic complexes with designed characteristics for the activation and conversion of CO2. The principles derived from these studies will be applied to electrocatalysis or photocatalysis, for the reduction of CO2 to biocombustibles like MeOH, HCHO or OHCOCOOH, with high values for the activity, turn over number (TON), and rate of the reaction (turn over frequency, TOF) as well as the lifetime of the catalyst. Why is this goal proposed? Because recently, there has been considerable focus on the rapid increased concentration of greenhouse gases in the atmosphere, and in particular CO2 is of major concern. This rise in greenhouse gas concentrations has been linked to the warming of the global climate observed since the mid-20th century, and is projected to result in extensive environmental damage. The Intergovernmental Panel on Climate Change (IPCC) in its fourth assessment report, published in 2007, suggested that the observed warming is “very likely” due to greenhouse gas emissions from anthropogenic sources, particularly the burning of fossil fuels. This concern, coupled with the projected need for independent and renewable energy sources, has focused considerable attention on the potential use of solar energy for the production of chemical fuels. A particularly attractive scheme would involve the use of solar energy to produce an electrical current, which would then be employed for the reduction of CO2 to provide carbon-neutral energy sources as alternatives to fossil fuels. Thus, the main two targets of this project are important issues in the modern society: global warming and the need of new sources of energy.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Statistical Machine Translation Using Monolingual Corpora'.

assistant: **Objectives**

As evidenced by a number of machine translation competitions, statistical machine translation is producing encouraging results for language pairs where large corpora of previously translated texts are available for training. However, in practice the availability of such data is often a severe bottleneck. We therefore propose a methodology that only requires a bilingual dictionary and monolingual text corpora of the source and the target language, which should considerably relieve the data acquisition problem. What we suggest is a two stage procedure. In the first step we create a database of translation equivalents by extracting them from a pair of comparable monolingual corpora using a bilingual dictionary in combination with automatically generated thesauri of related words. In the second step we translate new sentences by retrieving appropriate translation equivalents from the database and by merging them using a combinatorial approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tissue specific and inducible disruption of the mouse glucocorticoid receptor gene' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Glucocorticoids are crucial for the integrity and the function of the central nervous system function, for metabolic homeostasis and for preventing an over-reaction of the immune system. They bind to and activate the glucocorticoid receptor (GR). Most of GR -- mice, die within a few hours after birth because of respiratory failure. To circumvent this problem and to analyse in detail the function of the GR in a given cell type, I propose to apply a tissue targeted gene disruption approach, which would use the Cre recombinase/loxP system. I have flanked the, third GR-exon with loxP sites, thus, it should be deleted when Cre is present in a cell. By using mice expressing cre in brain neurons, T Iymphocytes or macrophages we would expect a specific GR gene disruption in those cell types. | I expect defects in behavioral, T cell population and inflammation responses, respectively. We propose to develop an inducible gene disruption system in mice. When fused with a mutated hormone binding domain of the progesterone receptor, cre recombinase responds to RU 486 but not to endogenous steroids. We can therefore induce recombination in cell culture. We will express this fusion protein in mice and see whether by injecting RU 486 we can induce recombination in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Carbon capture from syngas to Single Cell Protein (SCP) and use as fish feed ingredient'.

assistant: **Innovation**

Our SynoProtein project aims to develop, mature and demonstrate a novel carbon-negative process that enables high value creation from sawmill by-products through carbon capture and use (CCU). The consortium has developed an innovative process for the vertical integration of by-products from sawmill industry, i.e. feedstocks comprising only residues (no sawlogs), and conversion into fish feed ingredients, i.e. single cell protein (SCP), along with the production of biochar for animal feed. Thus, our process can provide novel, sustainable protein sources, as opposed to conventional energy- and climate-intensive soybean and resource-limited wild fish protein production routes to meet future demands. SynoProtein will demonstrate that 1.25 tons (t) of CO2-e can be captured from syngas via CCU for each dry-ton sawmill by-products processed. This clearly makes our SynoProtein innovation unique and is why it will introduce a green paradigm shift for the recycling and commercialisation of low-value by-products feedstocks into high-value bio-products. This project joins together a balanced consortium of 11 partners, covering the whole SynoProtein value chain, from industry, academia, and research institutes, which spread to 4 different European countries (Norway, Denmark, Sweden, and Germany), but with worldwide operation with their sister companies. Overall, we expect carbon capture of 200kt of CO2-e from syngas annually with our process by 2033, recovering 160kt/year of forest residues and producing 120kt/year of fish/animal feed for industry, valued at €175m. This also represents 260 jobs created in EU and reduced 120kt per year imported feed ingredient from other continents. Compared to fish feed production from soybeans, our SynoProtein is also expected to save carbon emissi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PAH Anaerobic Biodegradation Assessment by Stable Isotope Technologies' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Hydrocarbon pollution has been recognized to be a major environmental and human health problem that require accurate exposure assessment and remediation. Oil and oily products are extremely complex mixtures, containing hundreds (even thousands) of different compounds, among which polycyclic aromatic hydrocarbons (PAHs) are of greatest regulatory concern due to their potential toxic, mutagenic and carcinogenic properties. 2- and 3-ring PAHs are water soluble and can be transported over significant distances.Natural attenuation is a low-cost bioremediation option widely accepted for the clean-up of hydrocarbon polluted sites. Many efforts have been made to study and enhance aerobic biodegradation of hydrocarbons. However, anaerobic degradation of oily products is practically unknown, although in many environments, such as aquifers, marshes or intertidal zones oxigen is often a limiting factor.Some studies have proven the ability of microorganisms to degrade aromatic hydrocarbons in different conditions, but there is a significant gap of knowledge regarding in situ anaerobic biodegradation of these compounds (metabolism, key microorganisms involved, etc.).Stable isotope techniques (compound specific stable isotope analysis, CSIA, and stable isotope probing, SIP) are novel techniques which can help overcoming this situation, providing valuable information on biodegradation and coping suitably with linking biodegradation processes to microbial taxa. Despite their clear advantatges these techniques have seldom been applied to field studies.In the light of this situation, the main goals of this proposed project are to assess in situ biodegradation of PAHs under anaerobic environments in marine and fresh water systems, to describe microbial activities and to identify microbial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Assay on an almost optimal and simple selection method for balancing gain and genetic diveristy. The spm 3,2,1 strategy' (1994-1998).

assistant: **Concept**

Research objectives and content Our purpose is to assay a simpler selection method than those based on optimization techniques for balancing genetic gain and genetic diversity. It should be simple, robust and  breeding. This simpler sub-optimal scheme is based on weighted selection method, in which every family contribution in the next generation are assigned based on the family performance. Such a scheme, the so called Single Pair Mating 3,2,1 strategy, would have the following characteristics: I) Random allocation of mates, once mate per individual in order to obtain only full sibs families. 2) Division of breeding population into three family groups, one with the best, one with intermediary and one with the worst. From every family belonging to the first group are taken three offspring, two from every family in the second group and only one from the third group. 3) The number of families in the different groups will be chosen in such a manner that the proportion of the best families will be the same as that for the worst families, in order to keep constant the size of the breeding population along the generations. This new strategy will be compared with both an optimal selection algorithm and a simpler alternative with a still simpler alternative where all the contributions from the parents is constrained to a certain value (within family selection). This comparison will be made as a gain versus diversity diagram and will be study as a function of selection design variables. As genetic diversity measure will be used status number, fully developed in the proposed host institution. From the results it will be known how close to optimum 3,2,1 is and how this depends on the circumstances. Training content (objective, benefit and expected impact) By means of optimized sel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enhancing prediction of tropical Atlantic climate and its impacts' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Tropical Atlantic climate recently experienced pronounced shifts of great socio-economic importance. The oceanic changes were largest in the eastern boundary upwelling systems. African countries bordering the Atlantic strongly depend upon their ocean - societal development, fisheries, and tourism. They were strongly affected by these climatic changes and will face important adaptation challenges associated with global warming. Furthermore, these upwelling regions are also of great climatic importance, playing a key role in regulating global climate.Paradoxically, the Tropical Atlantic is a region of key uncertainty in earth-climate system: state-of-the-art climate models exhibit large systematic error, climate change projections are highly uncertain, and it is largely unknown how climate change will impact marine ecosystems. PREFACE aims to address these interconnected issues, and has the following goals:• To reduce uncertainties in our knowledge of the functioning of Tropical Atlantic climate.• To improve climate prediction and the quantification of climate change impacts in the region.• To improve understanding of the cumulative effects of the multiple stressors of climate variability, greenhouse induced climate change, and fisheries on marine ecosystems, and ecosystem services (e.g., fisheries, coastal vulnerability).• To assess the socio-economic vulnerabilities and evaluate the resilience of Atlantic African fishing communities to climate-driven ecosystem shifts and global markets.To meet these goals we bring together European and African expertise to combine regional and global scale modelling capabilities, field experiments and observation systems. Our target region includes areas more affected by climate change and by its consequences, European outermost regions