RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The governance of cross-border regional economic co-operation and the emergence of European cross-border regions - theory and empirical evidence' (1994-1998).

assistant: **Concept**

Research objectives and content Cross-border regions are a new form of subnational territorial unit, emerging in the context of European integration and globalisation. This project aims to undertake an original analysis of CBRs as spaces of indigenous economic development. Its primary objectives are: a) developing an appropriate conceptual apparatus; b) identifying the institutional conditions for and the obstacles to successful CBRs; c) generating policy-guidelines for cross-border endogenous development strategies. The elaboration of the theoretical approach is based on recent institutionalist theories which emphasise the importance of bottom-up governance mechanisms rather than top-down government. Since CBRs are not politico-administrative units, it is postulated that crossborder economic development is mainly based on governance leading to similar milieu innovateur-effects as shown for subnational regions. This will be demonstrated by several in-depth case studies on European CBRs including both successful and failed cases, which will provide guidelines for a bottom-up regional and innovation policy both at the European and cross-border regional levels. Training content (objective, benefit and expected impact) ? The project is directed towards a PhD degree and is accompanied by a recognised research training scheme. ? Leading knowledge in institutional economics and economic sociology will be acquired as well as methodological skills for operationalising institutional processes for empirical research. ? General research competence will be enhanced through academic 'synergy effects' including working groups, informal contacts and opportunities for publications. The project will function as a foundation for a research career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Comprehensive Climate Modeling of the Mid-Pleistocene Transition'.

assistant: **Concept**

The recent geological past is characterized by the cyclic growth and decay of large continental ice-sheets in the northern hemisphere driven by changes in incoming solar radiation associated with Earth’s orbital configuration. These glacial-interglacial cycles initially responded to the 41,000 year pacing of Earth’s axial tilt, but about 1 million years ago this periodicity slowed down to ~100,000 year cycles without any discernible change in orbital parameters, thus indicating fundamental shifts in internal feedback mechanisms. Yet, converging evidence for the origin of this remarkable change in glacial-interglacial pacing, known as the Mid-Pleistocene Transition, remains elusive. The CliMoTran project aims towards a comprehensive understanding of this unique climate transition through the employment of the Bern3D Earth System model. In order to enable fully dynamical simulations of glacial-interglacial cycles a readily available vertical integrated ice-sheet model will be coupled to the exceptionally computational efficient Bern3D model. Newly compiled paleoclimatic reconstructions will form important constraints on the past climate that can be directly compared to the wide palette of tracers implemented in the Bern3D model. This, together with the individually explored forcing parameters will shed light on the complex processes that were responsible for the remarkable slow-down of ice age cycles. As such, the project will advance the understanding of the relevant, often interwoven, driving processes of climate change, a much-needed undertaking for improving predictions of future climate in the face of accelerated anthropogenic carbon emissions. Conducted in a leading multidisciplinary research environment CliMoTran will thus not only expand the researcher’s previous
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spin Hall-Based Analog to Digital Encoder for Ultra-Compact Sensor Nodes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Low-power and compact analog-to-digital converter (ADC) is essential for sensor nodes as a link between the sensor and data processing. In restricted-area and high-speed sensors such as image sensors, each pixel needs a compact ADC for parallel data conversion. CMOS implementations of such ADCs have faced three challenges: 1) the difficulty of integrating ADCs with sensors in every pixel due to the large area of analog circuits exacerbated by poor scaling of analog circuits in CMOS, 2) the high static power of analog data converters, 3) limited resolution of CMOS ADC directly related to the process variations. Enormous effort has been devoted to addressing the challenges in such ADCs. Different types of ADCs from single-slope to delta-sigma have been investigated to achieve this, however, they are still far from the required area, resolution and power-density of the sensors. SHADE proposes a novel breakthrough approach benefiting from the small footprint of spintronics into the current ADC architectures. This has solutions for both voltage- and time-mode ADCs. SHADE will lead to at least three orders of magnitude smaller area in comparison with the state-of-the-art ADCs. The voltage-mode approach eliminates the memory array interfacing between the ADC and processor leading to a significant power-saving. SHADE is a major step towards filling the huge gap between the area of ADCs and the available pitch of pixels. The main objectives of this project are to characterize and model the behavior of the magnetic element containing both switching and oscillation features, design and simulation of both voltage- and time-mode quantizers through a developed model, adapting the quantizer with different types of ADCs usually used in sensors and fabrication and testing of ADCs. My ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Assessing cellular compartmentation of brain lactate using diffusion MR spectroscopy in vivo', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The idea has emerged that compartmentation of brain lactate, i.e. its distribution between different cell types and the extracellular space, plays a critical role in neurotransmission and brain plasticity. Dysregulations of lactate metabolism have also been reported in neurodegenerative diseases such as Alzheimer's disease. However, these notions remain challenged, and even fundamental mechanisms such as the astrocyte-to-neuron lactate shuttle, whereby astrocytes are supposed to export lactate to neurons to sustain neuronal energy needs, are still fiercely debated. This is largely due the lack of tools to evaluate cell-specific compartmentation of lactate in the living brain, in particular in Humans.In this project, we will develop new nuclear magnetic resonance spectroscopy techniques to non-invasively measure lactate diffusion, including in cortical regions. We will then take advantage of the unique ability of these methods to differentiate between metabolites diffusing in different environments, based on diffusion properties imposed by the microstructure, to quantify lactate in the extracellular space and, most importantly, in neurons and astrocytes. After validation in rodent models, these methods will be transposed on a clinical MRI system at ultra-high magnetic field, to gain unprecedented access to lactate compartmentation in the Human brain and its modifications during brain activity, plasticity, and in Alzheimer's disease. This will open a new research field for magnetic resonance spectroscopy in vivo.


**Keywords:** Magnetic resonance spectroscopy,  novel NMR sequences,  diffusion,  diffusion modeling,  numerical simulations,  lactate,  brain metabolites,  astrocyte,  neuron,  lactate shuttle,  biomarkers,  Alzheimer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Access to tamaris seismic testing large-scale facility' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Description:The seismic testing facility, TAMARIS, is part of the mechanical studies laboratory of the Mechanical and Technological Departement at the CEA Saclay research center. It has a permanent staff of 20 engineers and technicians. Its objectives are the development and validation of numerical models and calculation methods and the codification and seismic qualification of components.The TAMARIS facility includes the following equipment :AZALEE : 6m x 6m shaking table: it allows testing of specimens with a mass up to 100 tons in 3 directions with 6 degrees of freedom (translations and rotations). Independent excitations of any kind: (sinusoidal, random, shock, seismic with a 0-100Hz frequency range) may be applied. Max acceleration (with max. weight) 1g; max velocity 1m/s; max displacement: ±125mm (in horizontal directions).VESUVE: 3.1mx3.8m shaking table. Maximal mass: 20 tons in one horizontal direction; max acceleration (with max. weight) 1.2g; max velocity: 1m/s; max displacement: ±100mm.TOURNESOL: 2mx2m shaking table.Maximal mass: 10 tons; max acceleration (with max. weight); horizontal direction: 1.0g, vertical direction 1.3g; max velocity H 2m/s and V 1.3m/s; max displacement: V±100mm and H ± 125mm.MIMOSA: 2mx2m shaking table. Maximal mass: 10 tons in one horizontal direction; max acceleration (with max. weight) 4.g; max velocity 0.6m/s; max displacement: ±12.5mm.IRIS: pit allows testing of specimen up to 25m long. The diameter of the hexagonal pit is about 4m and lateral walls are equipped with anchoring devices.REACTION WALL: (4m height, 5m length) equipped with anchoring devices.All the equipment are connected to the acquisition system allowing recording and processing of 142 channels. It is connected to a scientific computing system with mechanical analy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular Targets Open for Regulation by the gut flora – New Avenues for improved Diet to Optimize European health' (TORNADO), addressing dissemination and exploitation.

assistant: **Impact**

Europe is facing major diet related health problems. Attitudes to eating habits have to be changed and the benefits of alternative treatment regimes substantiated. This can only be achieved by providing guidelines regulating health claims based on scientific data. Thus, there is a unique opportunity to use gut flora in potential treatment regimes and as a preventive target for major diet related health problems. TORNADO consortium proposes a systemic and comprehensive mechanistic approach to deliver scientific data that can be compiled as guidelines for European authorities.  TORNADO will determine the influence of diet on the gut flora and highlight the impact of gut flora on the immune system/other organ systems. TORNADO aims to investigate molecular targets that are subject to regulation by gut flora and diet that sustain health. This will be done by an increasing level of specificity, from (1) investigations of dietary habits and health in population cohorts, through (2) intervention studies in humans and animals and (3) analyses of the intestine and immune system, and also organs like adipocyte tissue, liver & brain, to pinpointing the impact of dietary influence on (4) cells and (5) potential functional molecular targets. TORNADO will deliver data that can be used to recommend biomarkers for evaluating effects of diet or microbes; refute, substantiate or improve health claims of existing products; generate novel functional food products. TORNADO's approach of microbe-to-mouse-to-man validation of dietary influence will enable more solid evidence for health claims and provide concrete deliverables e.g. Roadmaps to Health, Tailor-made Health-monitoring. Continuous state-of-the-art dissemination programs will increase impact.  TORNADO's program will accelerate future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The GnRH and GnRH receptor system in sea bass: improving spawning induction therapies' under Fifth Framework.

assistant: **Concept**

The sea bass is a major farmed fish in the EU but, as happens for other species, still presents unpredictable and unsynchronized spawns in captivity. The process of reproduction is controlled by the pituitary gonadotropins (GtHs), which release is regulated from the brain by the GonadotropinReleasing Hormone (QnRH). Our knowledge of the hormonal mechanisms of spawning are very poor in sea bass. Attempts to induce spawning have used a limited number of GnRH analogues (GnRHa) and have never considered the availability of pituitary GnRH receptors (GnRH-R), as determinants of gonadotroph sensitivity to the GnRH stimulus. The present project aims at investigating the GnRH system in sea bass, following molecular and physiological approaches, with special emphasis on the GrIRH-R. The GnRH-R will be cloned and distribution of mRNA studied by RT-PCR. The seasonal expression of GnRH-R, as well as sbGrIRH, sGnRH and cGnR11-11 mRNAs will be monitored, by developing specific dot-blot techniques, which will provide information on, the physiological relevance of each native GnRH and the moment of maximal gonadotroph sensitivity. On another hand, the GnRH-R cDNA will be stable expressed in HEK 293 cells and a culture system set up to perform studies on GrIRH-R binding potency of new GrIRHa; these data will be correlated with the biological activities of these GrIRHa in vivo (GTH-2 releasing potency and spawning induction capacity). We expect that the knowledge and tools obtained from this work, will help to the development of more effective spawning induction therapies for the aquaculture industry, based on the determination of the optimal physiological stage of the fish for hormonal treatment and the use of new GnRHa.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Toward new polymeric materials by metal-mediated controlled radical polymerization' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Controlled radical polymerization has revolutionized polymer research and has already started to revolutionize the polymer industry as previously unthinkable and complex polymer architectures are becoming available. However, access to a wider variety of polymer material is limited by the inability (so far) to control the radical polymerization of nucleophilic monomers. The host team is a world leader in the understanding and application of transition metal one-electron processes (homolytic bond breaking, atom transfer) to controlled radical polymerization and has recently obtained an important breakthrough in this area, by showing how the strength of metal-carbon bonds in organometallic complexes can be tuned to control the polymerization of vinyl acetate by the organometallic radical polymerization (OMRP) mechanism. The post-doctoral candidate has received outstanding training in precision polymer synthesis by ATRP from one of the leading polymer groups in Korea, and he has also familiarity with simple coordination compounds of a few metals commonly used for ATRP. Thus, he has the perfect background to give a strong contribution to this area. This fellowship represents an opportunity for the researcher to receive high quality training in the research area that is not yet highly developed in his own Country (China). Therefore, the training experience and the acquired know-how will be most valuable for a future reintegration of the researcher in his own Country either in an academic or in an industrial environment and for the development of a fruitful continuing collaboration with the host group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metabolic Networks that Link Longevity to Reproduction in Response to Nutrition', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In most western countries, life expectancy is increasing by 3 months a year. As the average age of the population increases, so too does the prevalence of age-related diseases such as cancer, cardiovascular and metabolic diseases, and neurodegenerative disorders. An essential component of ageing research is to understand the biological mechanisms that contribute to the ageing process at the cellular and molecular levels. This has major implications not only for the treatment of age-associated diseases but also for the promotion of healthy ageing.Studies of experimental animals and observations in humans have identified an array of genes and nutritional conditions that increase lifespan. However, these manipulations (genetic or nutritional) often have detrimental effects on other biological processes; for example, reproduction, metabolism, immunity or growth. This is an area of ageing research that has largely been ignored but that is critical to the success of strategies intended to slow ageing and thus the onset of disease.The primary goal of this research proposal is to understand how lifespan extension is linked to reproduction. We will use the nematode Caenorhabditis elegans as a model organism to identify novel conserved genes, molecules, and metabolic networks that link reproduction and longevity through nutrition. The proposed study is based on a unique set of preliminary data that identifies the first clear molecular links between these traits: a steroid hormone receptor and a reproduction-responsivelipase, both of which modulate lifespan extension achieved through changes in nutrition.Understanding the regulation and function of these genes and pathways will clarify at the molecular level how reproduction is linked to longevity. This may ultimately lead to inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Food safety screening: synthetic glucocorticoids' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The proposal aims to facilitate and catalyse the accelerated development of promising vaccine strategies from the laboratory to the clinic. The urgent need of a vaccine to prevent AIDS requires the most efficient utilisation of nonhuman primate resources to evaluate, select and refine the most promising AIDS vaccine candidates for clinical trials. The standardised evaluation of HIV-1 vaccine candidates for safety, immunogenicity and efficacy will be carried out under very controlled conditions in an unbiased fashion in well characterised non-human primates. This data will be constantly fed back to vaccine developers to assist them to accelerate development, to optomise vaccine components, and to refine immunisation protocols for clinical trials with greatest chance of success. A large number of new and innovative vaccine candidates and immunisation strategies will be evaluated.