RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Development of metal oxyde nanophase catalysts for emission control'.

assistant: **Innovation**

This project aims at developing new catalytic materials for environmental applications and in particular in the area of gas cleanup at moderate and high temperatures. Industrial areas of such applications of significant importance include mainly Three Way Catalysts (TWCs) for the automotive industry which currently employ exclusively catalytic systems based on expensive, noble metals (Pt, Rh, Pd) and catalysts for combustion and incineration plants. The project focuses on two particular aspects of environmental catalysis: hydrocarbons (HCs) removal during the car engine's cold start phases and NOx emissions reduction (a common problem of autoexhaust and combustion applications). Materials based on cerium oxide, which act as promoters of the catalytic activity of noble metals can be an answer to the NOx emissions problem. On the other hand, the problem of cold start emissions is at present, tackled with the concept of the preheating of a metallic procatalyst assembly by the passage of electric current (Three Way Electrically Heated Catalyst TWEHC). Thus the main objectives of the project are: - the synthesis via novel chemical routes of nanophase mixed oxide catalytic materials with tailored properties, which will be suitable for motor vehicle emissions control as well as for high temperature gas clean up applications - the development of Three Way Electrically Heated Catalysts based on perovskite materials, which will be capable of achieving substantially reduced HCs emissions during the cold start phases of an automobile catalyst.  Specific sub goals of the project will be: - the improvement of the thermomechanical properties of the catalytic supports, in order to make them appropriate for high temperature applications - the increase in chemical and thermal stability o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Novel Flavour and Fragrance Molecules from Native Chinese Flora'.

assistant: **Objectives**

This proposal seeks to identify new natural molecules from the Chinese flora that have potential application in the European flavour and fragrance industry. In order to achieve this, the techniques used for extraction, isolation and selection of target compounds must first be substantially improved. Improvements in the isolation, identification and selection of target molecules will be achieved through the novel use of a single machine combining gas chromatography, mass spectrometry and olfactive evaluation in a single pass of a plant extract. For the isolation of target compounds, we will research the use of Solid Phase Extraction technologies, originally developed by the pharmaceutical industry, and adapt and apply these for the separation of flavour and fragrance compounds from crude extracts. These are two major innovations.Novel molecules with desirable odour or taste characteristics will be evaluated by expert panels for their potential as new ingredients for use in perfume and flavour products.The candidate has 10 years experience in ethnobotany and the isolation of pharmacologically active molecules from plants. During the project she will learn new technical skills of taste and odour analysis and the personal skills of odour recognition, description and evaluation required to work in this field of research. This will be supplemented with training in general and scientific project management.With these new skills and techniques the fellow will return to the State Key Laboratory for Phytochemistry at the Kunming Institute of Botany, where she is currently an Assistant Professor, to establish a new research group to investigate the aromatic plants of Yunnan for species with economic potential.The project provides Quest with new products, the candidate with new ski
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'NORATEST: An e-Health solution for a better Alzheimer's diagnosis and management'.

assistant: **Concept**

Alzheimer's disease (AD) is a major medical problem and is currently an issue of global general interest as the total number of people with dementia is projected to reach ~80M in 2030 and almost duplicating this number by 2050. The lack of an efficient and affordable solution in the AD's health care sector has motivated our company Alzohis to develop NORATEST, a very unique and innovative e-Health platform producing significant improvements, in terms of speed efficiency, in the detection of neurodegenerative diseases. By means of a novel combination of biomarkers “signatures” detectable in the blood with a state-of-the-art computer algorithm NORATEST can discriminate patients suffering AD from those healthy ones, as well as detecting other neurodegenerative diseases. Our prototype, currently at TRL6, is the first reliable non-invasive molecular diagnostic method able to detect the disease in the very early stages, offering several competitive and innovative advantages such as: Cost-effective novel technology, fast, accurate, early ddiagnosis, data privacy coupled to smart analytics, user-friendly and highly scalable and adaptable platform. Our business model is a pay-per-use combined model of charging per analysis and direct online sales. The global AD market shows great opportunities for us since it was worth €2.5 B in 2016 and is set to reach €12.6 B by 2026 (CAGR of 17.5%). Worldwide we expect a market growth in both established and in developing countries, anticipating >5M annual AD's diagnoses in the two main markets leaders based in Europe (2.5-3.5M diagnoses/year) and USA (1.5-2.5M diagnoses/year) by 2024. Our company goal is to become the reference for AD's diagnosis in Europe. We estimated that in 5 years (end of Phase 2 project), we will accumulate 360K diagno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metrics, Models and Foresight for European Sustainable Food and Nutrition Security' (SUSFANS) targeting Horizon 2020.

assistant: **Abstract**

Strengthening food and nutrition security (FNS) in the EU requires a move towards a diet that supports sustainable food consumption and production. To gauge the policy reforms needed for this major societal challenge, the SUSFANS-consortium will identify how food production and nutritional health in the EU can be aligned. The multidisciplinary research agenda of SUSFANS will build the conceptual framework, the evidence base and analytical tools for underpinning EU-wide food policies with respect to their impact on consumer diet and their implications for nutrition and public health, the environment, the competitiveness of the EU agri-food sectors, and global FNS. Based on a conceptual model of the food chain and its stakeholders, SUSFANS will develop suitable metrics and identify major drivers for sustainable FNS, integrate data and modelling, and develop foresight for European sustainable FNS.Central asset is a coherent toolbox which integrates two complementary strands of state-of-the-art quantitative analysis: (i) micro-level modelling of nutrient intakes, habitual dietary patterns and preferences of individual consumers, and (ii) macro-level modelling of food demand and supply in the context of economic, environmental and demographic changes on various time-scales and for multiple sub-regions. The tools will bridge the current gap between policy analysis on the EU agri-food sector and the nutrition-health sector. Case studies and scenarios based on stakeholder input from consumers, food industry, farmers/fishermen, government and the scientific community, are instrumental in achieving this goal.The project will provide a comprehensive set of tools for assessing sustainable FNS in Europe, centred around the implications of the current diet for the sustainability of p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Management of the european round table on synchrotron radiation and free-electron lasers and other coordinated actions in this domain' (RT-SYNFEL) targeting Fifth Framework.

assistant: **Abstract**

Description:The standard deliverables under this contract are the co-organization and co-sponsoring of 3 regular workshops, 2 special meetings and one general meeting, providing a forum for open debate at the European level, and providing documentation through the Round Table homepage, in coordination between Elettra and Daresbury.The Round Table has at present four primary objectives:(1) It constitutes a forum for information exchanges and discussions concerning the EC transnational access support to European facilities in this domain, with the specific objective to enhance the effectiveness of the support by optimising the use of the facilities and avoiding needless duplications.(2) It promotes the initial steps for new initiatives of transnational cooperation(3) It advices responsible national and international organisations on the development of programs in this domain and stimulates the analysis of the trends and directions(4) It co-sponsors the organisation of schools and workshops to reach the above objectives and also to prepare the next generations of European scientists in this domain.The main results during the grant period were:(1) One regular general meeting in Villigen and two extraordinary meetings in Les Houches and Grenoble(2) A consensus assessment on the future developments of synchrotron radiation and FELs in Europe, with a published report(3) Five specialised workshops to promote new transnational cooperation activities(4) Three postdoctoral schools.In addition, the Round Table continued its standard activities of documentation, expert advice and promotion of cooperation at different levels.Project Manager:Giorgio MargaritondoDivisione EsperimentiStrada Statale 14, Km 163,5Basovizza (Trieste)34012Italy%Tel: +39-040-3758628Fax: +39-040-3758565E-Mail:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SOUTHPARK  - SOcial and Universal Technology HelPing to detect ARrivals via sdK'.

assistant: **Innovation**

predict.io has been set up as a company to address individual, as well as societal problems related to urban mobility and road congestion by building a smart, integrated, technology-based, easy to use system that renders  the traffic more efficient thereby decreasing negative effects on humans and the environment while at the same time fulfilling today's need for fast and individualised urban mobility. The technology is based upon an elaborated set of algorithms that can detect on mobile devices when a user arrives at a location in order to improve different kinds of traffic and mobility apps. The SOUTHPARK project is set up to fulfil two overall objectives: First, predicto.io will integrate the technology, with its automated start and stop detection in different mobility apps (including parking apps). This will be achieved when the SDK generates at least 1 million mobility data points a day for real-time applications as well as business analytics. These efforts will cover countries across the European Union. The goal is to enable more convenient, more reliable, safer, environmentally friendlier, and efficient mobility solutions.Second, the SOUTHPARK project will bring the arrival detection close to perfection. This will be reached by the reduction of localisation costs and implementation time. predcit.io will build up significant machine learning capacities that constantly improve the existing algorithms in order to provide faster, better anticipating, more adaptive and less battery consuming STOP detection. Fulfilling this objective will reduce the adaptation costs and time to localise to new settings by estimated 75%.The outcome of the project will be an ensemble of algorithms that had been tested on large scale in the operational environment. The arrival detection c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chemicals as contaminants in the food chain: an NOE for research, risk assessment and education', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The harmful effects of dietary chemical contaminants represent a major health problem in every society. However since there is insufficient information it has proved difficult to assess the health risks they constitute for humans, especially women, newborn children, and other susceptible populations. Nuclear receptors regulate critical cellular processes such as cell growth and differentiation, metabolic processes and other. Endocrine disrupting agents, acting through nuclear receptors, are thus involved in many different pathological situations such as tumour development, metabolic disease and obesity, coronary heart problems etc. Europe has recognized this threat and extensive research efforts have been undertaken to identify the problems caused by food borne contaminants. However, the full European potential in this area of research has not been utilised because European research is fragmented. There is little coordination of the European research and this lack of integration results in a sub optimal European research atmosphere. To address this issue 18 Universities and SMEs have decided to form a European wide Network of Excellence (NoE) under the leadership of the Karolinska Institutet. We will harmonize the whole chain of events from sampling procedures, to risk assessment and legislative measures. The participation of multiple research areas will facilitate greater efficiency of data production, information flow and communication of knowledge in key areas such as sampling methods, identification and analysis of chemical residues and identification of relevant marker proteins. End results will include training programmes and provision of rationalised information for assessing the risk that these compounds pose to human health. Channelling information to the gener
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Polymer and elastomer actuator concepts for engineering' to be submitted under Sixth Framework.

assistant: **Abstract**

The combination of two electromechanically active materials with very different properties into a single active structure is a novel concept of wide implication: the actuation properties of such active structures would be highly tuneable, and actuation modes of a high complexity made possible, with numerous potential applications like active exoskeletons, micro air vehicles, autonomous robots, variable stiffness materials, haptic displays, active damping and noise suppression, etc.Two electro-active polymers will be employed, piezoelectric polymer and dielectric elastomer. Their actuation properties are well-known, and they constitute the two main electric-field actuated polymers. They are complementary in the sense that dielectric elastomer actuators (DEA) easily output strains of more than 200%, but provide actuation stresses of just a few MPa. Conversely, piezoelectric polymer actuators (PPA) display very low strains, usually lower than 1%, but return actuation stresses of several GPa. Since both DEA and PPA are well understood, their combination is technologically feasible.These complementary properties will be combined into active structures, with 1, 2, and 3-dimensional spatial variations in materials and electrodes, displaying a wealth of actuation modes and properties. A range of spectroscopic techniques will be applied to understand the interplay between two active materials; many of these methods were developed by the host. Continuum and finite element models ensure that experimental results can be explained by known physics. The proposer's expertise lies mainly in DEA.This proposal aims to resume his research career, by diversifying his skills into the other main electric-field actuating material, the polymer ferroelectrets, in which the host is a leader. Wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In vivo choreography of DNA molecules and repair proteins during the search for homology' in the context of a Seventh Framework call.

assistant: **Objectives**

Double-strand breaks (DSB) constantly challenge the integrity of the cellular genome and are important contributors to cancer and genetic diseases. Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes and chromatin constituents that are organized into centers (foci). The outgoing laboratory recently developed powerful methods to explore the dynamics of focus assembly/disassembly in vivo. Using these techniques, I will explore one of the most intriguing steps of homologous recombination: the search for homology. During homologous recombination, the broken DNA searches for intact homologous dsDNA within the entire genome. To elucidate when and how the process of homology search occurs in vivo, I will visualise the movement of a donor and an acceptor sequence, as well as recombination factors, before, during and after double strand break repair. I will take advantage of the elegant yeast genetic system and explore the effects of targeted mutations in key enzymes involved in this process. In the return laboratory, I will to transpose the assay developed in the outgoing laboratory in mammalian cells. With the aid of the Marie Curie fellowship, I propose to spend my post-doctoral period to evolve from single molecule approaches in vitro to genetics and in vivo systems involving multiprotein complexes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Numerica and Analytic Study of Relativistic Jets' in the context of a Sixth Framework call.

assistant: **Objectives**

The physical conditions in relativistic jets generated in vicinity of black holes or neutron stars may not be directly accessible to current observations, the reason being that the detected radiation originates from a non-thermal population of relativistic particles which may represent only a part of a more complex system (including a thermal component carying most of the mass of a jet). This project applies state-of-the-art numerical techniques as well as carefully developed analytic models to link the phy sical state of the jet to the radiation associated with the gamma ray bursts (GRBs) and active galactic nuclei (AGN).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multifunctional theranostic nanoparticles using pH-responsive DNA-nanoparticle conjugate for effective cancer therapy' in the context of a Seventh Framework call.

assistant: **Objectives**

Cancer is a leading cause of death worldwide, accounting for 7.6 million deaths in 2008. Although conventional cancer chemotherapy can provide profound benefits, seriously adverse side-effects still cannot be avoided, due to lack of specific targeting nature of current treatments. Nanomedicine can reduce such side-effects by exploiting characteristic properties of tumors for targeted delivery and therapy. Despite extensive research, most nanomedicines developed so far have relied on passive targeting using a single therapeutic modality, which are inefficient for treatment of challenging conditions such as multi-drug resistance.Recently we developed a pH-responsive-DNA-GNP conjugate based nanocarrier that numerous features required for an ideal drug nanocarrier, e.g. uniform small nanoscale size, resisting non-specific adsorption, non-toxic, biocompatible, water-soluble, stable, and having high drug loading and controlled release capacities. It can offer efficient and pH-triggered drug release suitable for effective cancer chemotherapy at the cellular level using doxorubicin, a widely used chemotherapy drug.Herein we will extend it into a more effective, multifunctional nanomedicine that can offer simultaneous biomodal chemotherapies with hyperthermia and MRI imaging capacities. First, we will prepare, characterize, and evaluate their drug loading & release profiles in buffer; then we will study and quantify their cell- & cell-specific- uptake and drug delivery efficiency, and then evaluate their toxicity, cytotoxicity & cell-specific cytotoxicity with cancer cells (incoming phase), and finally evaluate their synergistic therapeutic efficacy at cellular and preclinical level (re-integration phase). This project will greatly benefit both the fundamental research in nanome