RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biodiversity of Microbial mats in antarctica' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Micromat: Biodiversity of microbial mats in Antarctica The microbial mats from Antarctica will be used as a community model for the determination of biodiversity by different approaches, as well as a new source of valuable biotechnological compounds. We will assess and improve the different steps of the study of the microbial cultivated and 'yet-to-be cultivated' biodiversity of bacteria, protists, and fungi. In addition, we will use this Antarctic gene pool as a biotechnological resource, by screening the strains and environmental samples for novel cold-adapted enzymes, pharmaceutical compounds and cyanotoxins. Microbial mats grow on the bottom of Antarctic lakes with salinities varying from freshwater to hypersaline. The mats have accumulated for thousands of years and are virtually undisturbed due to the particular climatic conditions and the absence of larger metazoans. Other types of mats grow in temporary flowing waters in summer and become dried out and frozen in winter. The mats are inhabited by all major groups of microorganisms (bacteria, protists, fungi) which have developed adaptations to the harsh environmental conditions, including UV-screening pigments, anti-freeze proteins, resistances to desiccation and hypersalinity, low temperature enzymes... New species of microorganisms have been described from Antarctic biotopes and it is expected that this continent harbours novel and unique gene pools, yet to be discovered and cultivated. It has recently been demonstrated that classical cultivation techniques on standard media resulted in the isolation of only a small percentage of the true biodiversity and that molecular methods like those based on the SSU rDNA detected many as yet unknown organisms. In addition, the molecular information (sequences, probes,....
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AQUA4D - For an efficient use of irrigation water' to be submitted under Horizon 2020.

assistant: **Abstract**

Water is becoming scarcer, droughts are becoming a big problem, and together with high levels of soil salinization and nematodes infections, are endangering the agriculture sector all around the world. Planet Horizon Technologies (PHT) presents a Swiss-made innovative, chemical-free and eco-friendly solution to face agricultural problems: AQUA4D. The basic principle of AQUA4D technology is the change of water structure with electromagnetic (EM) waves. This technology has proved to be highly effective in the horticulture and fruit sector. Now, PHT aims to expand the use of this technology to the main crops sector (cereals and grains). To do so, we adapted the current modular system to cope with higher flow-rates of water needed for sprinkler irrigation systems – a market that was valued as 1.57 B€ and it is expected to grow at a CAGR of 14.97% during the period 2017-2022.AQUA4D facilitates a better dissolution and distribution of minerals, promotes water retention in the soil and allows for absorption of minerals by the plants, allowing 25% reduction on water and fertilizer use. At the same time, AQUA4D increases the natural resistance of plants against diseases, avoids nematode attacks in roots and prevents clogging and biofilm in pipes. AQUA4D presents the lowest power consumption (able to be powered with small solar panels) and the lowest running cost from all water treatment technologies in the market, allowing its use in a low margin market such as the main crops production. The result expected will be an improvement of up to 20% in the production yield with a fast payback, between 6 and 24 months. Commercialization of high flow rate AQUA4D is estimated to begin in 2020 and PHT estimates to sell 9,000 units during 2020-2024 period, which will render us a cumulative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Vision in color: Molecular mechanism of the color visual system' under Seventh Framework.

assistant: **Concept**

The retina of vertebrates contains two kinds of photoreceptor cells, the abundant rod cells, containing the rhodopsin pigment, and the much scarcer cone cells, with the blue, green and red cone pigments. Upon photoactivation, they interact and activate a specific heterotrimeric G protein, transducin, initiating the visual signalling phototransduction cascade. To date, little information about the interaction cone pigment-transducin is known.The main goal of this project is to provide an overall picture that integrates in a coherent scheme the molecular basis of the interaction cone pigment-cone transducin following two approaches. In a first approach, Dr Ramon proposes to unravel the effect of cone degeneration associated mutations found in cone pigments, and transducin α subunit genes. To do that, these mutant proteins will be expressed (using eukaryotic or prokaryotic systems) and characterized by means of immunocytochemic and spectroscopic techniques.On a second approach, Dr Ramon will study the interaction cone pigment-cone transducin by means of Surface Plasmon Resonance spectroscopy, providing the kinetic features of the biomolecular interactions and NMR spectrosocopy, by determining the conformation of cone transducin upon cone pigment bindingThe collaboration of different groups with the host institution -which will allow short stays of the applicant in these laboratories- and their involvement in the development of this project will help to disseminate the results not only Europe, but worldwide.Cone pigments have not been widely studied due to the scarcer amount in nature as compared with the rod pigment rhodopsin. most of the information available on cone pigment phototransduction is inferred or extrapolated from the rod system due to its similarities with rho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Osteoarthritis patient cohorts in the dish - personalised cellular drug development tools for osteoarthritis precision medicine' (O-POINTED), addressing dissemination and exploitation.

assistant: **Impact**

Osteoarthritis is the fastest growing cause of disability worldwide. Still, there is currently no drug available that targets the underlying pathophysiology of osteoarthritis. Clinical trials testing disease-modifying drug candidates consistently fail. This is because osteoarthritis is a complex disease and currently used drug development tools completely disregard patient variability. Consequently, such non-personalised drugs fail to reach high enough response rates in highly variable osteoarthritis patient populations. O-POINTED is the first tool to enable pharma and biotech companies to personalise the osteoarthritis drug development process. O-POINTED is a cellular test system based on personalised and expandable cell lines generated from a cohort of more than 50 osteoarthritis patients. It represents osteoarthritis patient variability including all the main disease phenotypes (bone-, cartilage-, synovium-driven). Compared to conventional test systems, it is easier to use and more relevant, with the unique benefit of representing osteoarthritis patient variability. The combined O-POINTED business model includes a double one-off revenue (product plus consumables) and recurring revenue (milestone-based payments). We estimate that O-POINTED will create €2.9 million revenue and 15 new jobs, 3 years after commercial launch. We have a key customer already testing a minimal viable product of O-POINTED and seek Phase 1 support to evaluate the feasibility of scaling up to a European and Global dimension.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Health sectors reform, coping strategies and professional identity of phc clinicians in Mozambique and South Africa' to be submitted under Fourth Framework.

assistant: **Abstract**

The present research proposal aims at a deeper understanding of the coping strategies of health professionals, their consequences and determinants, including structural determinants. Based on this understanding it further aims to influence the strategies of development and implementation of health personnel norms and policies. The fields for this research are Mozambique and South Africa. The purpose is however to develop a framework of analysis allowing to address these questions to be addressed in other societies.The underlying hypotheses are: * That the coping strategies of health professionals are among the key elements for attempts at health sector reform. * That the structural conditions that affect these coping strategies include the characteristics of the organisation of the health care system as well as the social, cultural and economic environment of the society, and the way history and politics have shaped the development process and its impact in the process of socialisation of students and young professionals. * That in order to make coping strategies of individual health personnel compatible with the objectives of the health care system it is essential to promote the existence, acceptance and interiorisation of a role model of a generalist practitioner (patient-centred, community-oriented and guided by the universal principles of family medicine) as a cornerstone of health sector reform. * That even in an adverse social environment it is possible and feasible to create favourable conditions that allow health personnel to adopt coping strategies compatible with equity and quality health care delivery, while responding to their aspirations for survival, social status and professional satisfaction.Measurable objectives* To identify historical factors of releva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Existence of Instabilities in Hamiltonian Systems on lattices and in Hamiltonian Partial differential equations' (INSTAB12).

assistant: **Concept**

The study of Arnold diffusion in Hamiltonian systems has received a lot of attention in the last years. This phenomenon arises when a small perturbation in a system causes big changes in it leading to global instabilities. In recent years there have been partial results characterizing this phenomenon and proving its existence in Hamiltonian systems but mostly for systems of low dimension. This project wants to be a step forward showing that such instabilities also arise in Dynamical Systems on lattices and in Hamiltonian Partial Differential Equations (HPDEs), which can be seen as Dynamical Systems of infinite dimension. We will focus our attention on two different problems: the Fermi-Pasta-Ulam model and the energy transfer phenomenon in Hamiltonian PDEs.Regarding the first part, we will consider the Fermi-Pasta-Ulam model (FPU), which is a  model of a discretized nonlinear string. One would expect that as time evolves, the system reaches equipartition of energy among the modes. Nevertheless, numerical experiments by Fermi, Pasta and Ulam (1955) showed that in some settings it is not reached in the time range for which the numerical experiments are reliable. This fact is called the FPU paradox. To understand how the equipartition of energy can be reached after longer times we plan to find instability mechanisms in the low energy regime.In the second part we will prove the existence of solutions of some HPDEs in the d dimensional torus which undergo transfer of energy to higher modes as time tends to infinity. This transfer of energy can be measured by the growth of high Sobolev norms. First, we plan to prove the existence of orbits with arbitrarily large finite growth of Sobolev norms for different Hamiltonian PDEs. Finally we plan to prove Bourgain's conjecture, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PhOtonics QUantum Bernoulli Factory' to be submitted under Horizon Europe.

assistant: **Abstract**

A Bernoulli factory is a randomness manipulation routine that takes as input a Bernoulli random variable and provides as output another Bernoulli variable whose bias is a function of the input bias. Recently proposed Quantum-to-Quantum Bernoulli Factory schemes encode both input and output variables in qubit amplitudes. This primitive could be used as a key ingredient for quantum networking at the interface of quantum computing and cryptography, as well as a subroutine for more complex quantum algorithms thus extending current approaches of randomness generation and manipulation. An open challenge is to design an approach for the implementation of a general and “low-cost” Quantum-to-Quantum Bernoulli Factory. Via a photonics technological platform, the goal of POQUB is 1) to develop a general scheme of Quantum-to-Quantum Bernoulli Factory; 2) to identify relevant use cases within blind quantum computing, via interaction with industries; 3) to design a roadmap for the innovation technological transfer of all the PoC outcomes. As a technological platform, POQUB will exploit reconfigurable photonic circuits which represent a compact, stable and scalable solution due to its natural potential for unlocking versatile and high-speed applications. The developed scheme is expected to have relevant applications also in several other scenarios for quantum technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Effective and Affordable Flu Vaccines for the World'.

assistant: **Innovation**

Despite the availability of flu vaccines for decades, influenza is still an important disease in both developing and developed countries with 500,000 casualties annually and many more people affected. From a global health perspective, the lack of effectivity, availability, affordability, and accessibility of flu vaccines significantly limits our ability to respond to the seasonal flu every year and in the event of a pandemic. Currently, a low vaccine effectivity of 40% implies that 60% of vaccinated people are not sufficiently protected, with low confidence further contributing to limited uptake/immunization. Within INDIGO, public and private R&D organizations in India, EU and US collaborate on the development of two novel influenza vaccine concepts that meet the requirements of global vaccination, aiming to achieve less non-responders, lower costs, and better accessibility:1)TETRA-LITE, an affordable seasonal flu vaccine with high efficacy at low cost and possible exploitation within a few years after completion of the project; and 2)PANDEMIC-PLUS, a further improved flu vaccine concept dealing with technological shortcomings and challenges of wide-spread use.The first approach combines a low dose of a commercial, inactivated, seasonal flu vaccine with a novel, potent adjuvant CMS (LVA). The adjuvant was tested in humans for the first time within the INDIGO project and was proven safe and well tolerated. When combined with just one-fifth of the standard flu vaccine dose, CMS induced immune responses comparable to full-dose vaccines without adjuvants. This suggests significant potential for antigen sparing, which could lead to more cost-effective vaccine production. The second approach builds on three innovations: 1) a novel recombinant HA with increased immunogenicity,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecotoxicological Assessment of Remediation Techniques for Contaminated Soil Materials' (1994-1998).

assistant: **Innovation**

Different technologies are proposed for the remediation of industrially contaminated sites. It includes thermal, physico-chemical, and biologieal proeesses performed separatelly, in series or in a eombined way. Nevertheless the safety of their effieieney-eosts relationship is not guarantied due to some bottlenecks concerning the hazard assessment of polluted or treated materials for their future reuse. An urgent need of complementary tools for the assessment of remediation techniques efficiency, at the pilot or industrial scale, is expressed for a better development of processes and assessment of soil reuse feasability. At the present time, the hazard assessment of polluted or treated materials is limited to analytical chemistry methods applied after the selection of specific or global physico-chemical parameters which are enough sensitive, perninent and cost-effective. In addition, leaching tests are used to assess the hazard linked with the transfer of toxic elements or compounds through water flows and the potential contamination of groundwater systems. This method is efficient when the number of pollutants is limited to a homogeneous family of compounds concerning their potential behaviour within natural media. In the presence of complex mixtures in soils or sub-soil systems, this method cannot guaranty the safety of results. As a matter of fact, an exhaustive determination of toxic compounds is not possible on a technico-economical basis due to the number of physico-chemical parameters to be determined and the lack of knowledge on the interferences existing between the different toxic compounds and soil components. On the basis of enhanced physico-chemical paramater selection schemes and of complementary ecotoxicologieal bioassays on selected biological targets, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Embryomics : reconstructing in space and time the cell lineage tree' to be submitted under Sixth Framework.

assistant: **Abstract**

Embryomics is devoted to the morphodynamical reconstruction" of the cell lineage tree underlying the processes of animal embryogenesis. We will design a set of strategies, methods and algorithms to "sequence" the cell lineage tree as a branching process a nnotated in space and time. We view this highly interdisciplinary project as the foundation of a new scientific field that we call Embryomics with a reference to Genomics. In the same sense as Genomics, Embryomics is both a scientific field and a technolog y to gather data with a lot of potential applications. But the Embryomics data is much more 'complex' than a mere DNA sequence as it does not appear as a linear static information in one dimension but as a branching dynamical process displayed in space and time. To deal with this information, we undertake a highly novel and most promising approach based on the strategies of the mammalian visual system. Our goal is to fully reconstruct the dynamics of cell divisions and movements from time-lapse series of hi gh-resolution optical sections obtained by multiphoton laser scanning microscopy throughout embryonic development of live animals. Embryomics will allow the automated tracking of events such as cell division and cell death in live embryos and give us acces s to parameters such as the rate of cell proliferation in time and space. This kind of data is highly relevant to investigate stem cell populations, early steps of cancerogenesis and drug effects in vivo. The post-genomic era needs such a systematic approa ch at the level of the cellular organization to achieve an integrated understanding of biological processes. In addition, through the investigation of four different organisms with key phylogenetic positions, we aim at promoting the use of non-mammalian an ima