RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Coherent heat and energy transport in quantum systems'.

assistant: **Objectives**

We are nowadays capable of controlling and manipulating quantum systems as never before. Quantum technology is close to bringing IT devices to mass scale production. The improvement in the accuracy of fabrication and control of quantum systems starts to pay some results also in different fields of research and application, such as biology.Despite the successes already achieved, it is surprising that the problem of how quantum systems exchange energy is, from many points of view, still open. How to define work and heat at quantum level? Is it possible to design quantum devices that manage heat and energy transfer in an efficient way?Here we focus on a particularly promising way in which quantum systems can exchange energy and heat. Our experimental partners have shown that the heat transferred between two superconductors connected by a Josephson junction has a contribution that depends on the phase difference between the superconductors. As the phase difference can be controlled by a magnetic flux, this open a completely new way to manipulate and transfer heat at the quantum scale.We will study how to exploit this coherent heat transport. The objective of COHEAT is to develop techniques and design circuits aimed at controlling, measuring, distributing, storing and converting heat. COHEAT will lay the theoretical basis for what can be called “coherent caloritronics”. Similar analysis can be extended to other quantum systems as the Bose-Einstein condensates, which represent a test bench for more exotic cases, in which the systems are driven out of equilibrium.COHEAT will have a strong and interdisciplinary scientific and technological impact. The possibility to transfer heat at mesocopic scale, and to manipulate it fast, easily and locally, has countless applications: quan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Alpha-immunotherapy' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Specific Objectives:1. Achieve a sufficiently qualified Ra-226 target production and post-irradiation chemical processing (Ac-225/Ra-226 separation and purification) to allow regular irradiation (e.g. bi-monthly) of about 30 mg Ra-226 (each time) at the cyclotron at FZK to produce Bi-213 generators for ongoing pre-clinical and clinical trials in Europe and US;2. Succeed in obtaining a license agreement with an external company to take over the long term / large scale Ac-225 production including the use of ITU facilities and training by ITU experts in the first phase of the exploitation;3. Provide scientific support to the hospitals carrying out trials on Non-Hodgkins lymphoma, prostate cancer, stomach cancer and multiple myeloma;4. Promote further the application of this new cancer therapy by organising a 1 or 2 day dedicated alpha-immunotherapy symposium at ITU in 2002.Planned Deliverables:Specific deliverables to DGs:- DG Entr : 1 shared cost action to be finalised in 2002 focussing on the pre-clinical and clinical testing of Bi-213;- Research DG : Proposal in preparation for new shared cost action with medical partners throughout Europe on pre-clinical and clinical testing of different constructs using Bi-213 and At-211 in the hospitals;- JRC : Close involvement of JRC Headquarters in assessment of licensing possibilities through e.g. Agreement of prior opportunity (Alpha-immunotherapy serves as kind of test case).As a result of the research:- Publications;- Patents;- Pre-clinical and clinical protocols;- Workshop proceedings.Summary of deliverables made by: 31/12/2001- Through a series of earlier technological achievements, the irradiation of 30mCi targets of Ra-226 in the FZK cyclotron was continued. The main achievement has been reached by carrying out the full pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Linking global species richness and beta diversity to individual species distributions at multiple phylogenentic and spatial scales' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Recently, unprecedented amounts of information on the World’s biodiversity have been assembled and striking patterns in its distribution have been described, such as the latitudinal gradient of species richness or the relationship between the richness and climate. Major challenges are to establish linkages between the various biodiversity patterns, to understand the mechanisms generating these patterns, and to make the results of macroecology useful for conservation biology and policy. This project will address these through the following objectives: (i) I will explore global patterns of aspects of biodiversity other than species richness, namely beta diversity; (ii) I will use the method of taxonomic deconstruction of global biodiversity patterns to assess their universality and I will examine if their taxon-specific forms can be linked to life history traits or phylogeny; (iii) I will improve methods designed to predict biodiversity in poorly surveyed areas or in areas under the thread of climate change. To address this I will use global data on birds, mammals, amphibians and recently developed statistical methods (spatially explicit regression techniques, phylogenetic analyses, randomization procedures). I will do the analyses at multiple grain resolutions. I will develop software that will enable my methods to be accessible to wide academic community. The project has relevance for biodiversity conservation both world-wide and within the EU and it will improve some of the methods currently used in biodiversity research. The project will establish vital collaboration between EU and Yale University. The project will provide me with training in cutting-edge biodiversity informatics, programming and novel evolutionary approaches. The hosting Jetz Lab at Yale University h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Innovative Enterprise Conference on Circular Economy and Access to Risk Finance'.

assistant: **Innovation**

The conference will address the challenges and opportunities for the finance sector when funding the circular economy andthe transition from the linear to the circular economy. The conference is organized in the framework the LuxembourgPresidency of the Council of the European Union and of a partnership between the Grand-Duchy of Luxembourg and theEuropean Investment Bank (EIB) in the framework of the InnovFin Advisory program of the European Commission.The resulting report will be presented at the conference and its findings will be discussed.The conference will allow the participants (banks, funds and all actors from the finance sector as well as public authorities, ata national and European level, responsible for the design and the implementation of state aid and support tools) to exchangebest practices and know how on how to finance the circular economy while benefiting from the findings of the EIB report. Theknow-how developed by the finance sector will be an important support to companies implementing circular economyprincipals.This Luxemburg Presidency Innovative Enterprise Conference in December 2015 is of high Political priority and particularlytimely as the circular economy package will be published on the 2nd of December 2015. The Conference will also allowgiving to the Luxemburg Presidency a high visibility on its contribution to this major phase of President Juncker Plan.The conference will address such topics as the political response to the macroeconomic situation, ways to boost growth,jobs and competitiveness through innovation, how thefinancial instruments, facilities and accompanying measures launchedunder Horizon 2020 can enhance access to finance for research, innovation and SMEs and also interactions between thesefinancial instruments, COSME's and E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of an innovative supercritical fluid decellularization technology to produce advanced biocompatible scaffolds for complex musculoskeletal regeneration' to be submitted under Seventh Framework.

assistant: **Abstract**

The need for organs and tissues to treat end-stage organ failure and debilitating musculoskeletal conditions is a huge health requirement for Europe. Current treatments include organ transplants, bone grafts and tissue engineering and regenerative medicine approaches. Significant hurdles and limitations exist with all approaches: shortage of organ donors leads to patient mortality, autogenous bone grafts are often associated with pain and morbidity and allogeneic bone grafts can fail to vascularize and remodel. Existing use of scaffolds, cells and growth factors can also be problematic with worrying complications of negative host response, remodelling and rejection. A highly skilled UK researcher (Dr. Lisa White) with extensive experience in supercritical fluids will join the world leader in extracellular matrix materials (Dr. Steve Badylak at the University of Pittsburgh, USA) to gain unique skills in  decellularization to collaboratively address these issues. In a pioneering step, an innovative supercritical fluid decellularization (SFD) technology will be developed. This SFD process will be utilized to decellularize whole organs to provide functional biological scaffolds with vascular networks, providing promise for whole organ engineering. Application of the SFD technology to bone will produce a powerful ex vivo model that will be utilized to provide essential information on cell response and healing. Finally, this ground-breaking SFD technology will produce advanced biologically compatible scaffolds for the regeneration of complex musculoskeletal defects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pregnancy and Reproduction Organ-on-a-chip Models' to be submitted under Horizon 2020.

assistant: **Abstract**

PreTerm Birth (PTB) occurs before 37 weeks of gestation. Of 60,000 babies born prematurely every year in UK, ~1,400 die. Premature babies show increased risks of long term neurodevelopmental deficits and chronic diseases.Preterm Rupture of the foetal Membranes (PROM) is a syndrome attributable to multiple factor. Evidences linked environmental toxicant exposure and infection with a decreased fertility and an increase PTB rate.Studies of these topics suffered for limits of in vitro cell culture (e.g. absence of extracellular environment, dilution) and anatomical, physiological, endocrine differences between human and animal models. Long term goal of this project is to create Organ-on-a-Chip (OoC) models of the human endometrium and the human foetal membranes to assess the effects of environmental insults, such as infection or inflammation, to exacerbate preterm birth. An overarching goal is to utilize these OoC models to identify personalized therapy to improve and preserve fertility.This project aims to1.Implement an OoC model to replicate the physiology of the human endometrium and the development of the foetal membranes during pregnancy. This will be achieved by adding human amniotic epithelial, chorionic trophoblasts and maternal macrophages in the existing OoC.2.Define the individual contributions of each cell type in the endometrium to paracrine signalling events that lead to PTB. A sub-micrometric polymeric, porous membrane will be integrated in the chip, will allow chemical communication between the cellular compartments of the OoC, will support formation of cell layers and will favour close proximity between the different cell types.3.Monitor metabolic activity and identify PTB biomarkers. Changes in metabolic activity of each cell types, biomarkers of infection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'RECYCLING ALKALINE BATTERIES INTO MICRONUTRIENT FERTILIZER' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The majority of alkaline battery recycling plants are working at maximum capacity and cannot cope with increasing demand. Safety issues, vast energy consumption and high process temperatures make smelting plants a dangerous and outdated technology. Battery manufacturers have produced and distributed over 10 billion alkaline batteries worldwide and the amount of used batteries increases at six percent annually. Many countries are unable to keep up with the environmental impacts. Fifty-one percent of global agricultural land and thus food plants globally suffer from micronutrient deficiency. Tracegrow introduces new recycling capabilities for alkaline battery and an innovative end product—micronutrient fertilizer. The proposed feasibility study enhances the company’s potential for international expansion and capability to create a new niche market in recycling used minerals into ecological soil micronutrients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'NEw Physics searches with tAu Leptons'.

assistant: **Innovation**

If the Standard Model (SM) of particle physics succeeds in describing the behaviour of fundamental constituents of matter and their interactions observed experimentally, it is unable to solve the most important riddles of our time such as the nature of the dark matter or the origin of the matter-antimatter asymmetry of the Universe. Manifestations of physics beyond the SM are extensively searched for, in particular through heavy flavour decays that are rare or forbidden in the SM. In this domain, final states involving electrons and muons are widely studied while channels involving tau leptons are much less known because of their challenging reconstruction. The interest of decays involving tau leptons is also dramatically reinforced by the recent anomalies reported in tests of lepton flavour universality violation and rare B decays, suggesting a special role of the third family. In particular, in the presence of physics beyond the SM, lepton flavour violating tau decays and rare B decays into tau leptons could be just below the current experimental limits.With the NEPAL project, I propose to build a team of analysts that will exploit the worlds largest B and tau samples recorded in the clean environment of an electron/positron machine by the Belle II experiment. The full detector operation will start end 2018 and aims at recording five times more statistic than the total previous flavour-factory experiments by 2020, and a final dataset of 50 inverse attobarns by 2025. Thanks to the development of a common analysis framework, sophisticated machine learning techniques for signal selections, the use of a full event interpretation and the reconstruction of 95% of tau decays, my team will search for more than thirty lepton flavour violating tau decays and rare B decays into
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Lab-on-Skin:  A wearable medical device for improved clinical trial monitoring' in the context of a Horizon 2020 call.

assistant: **Objectives**

The high costs and long timelines associated with drug development are a major burden to society. The healthcare industry is increasingly looking for systems and processes to reduce the costs of developing and testing new drugs. Commercial wearable medical devices have recently found their ways into clinical trials, with pharma companies looking for new tools to monitor patients enrolled in clinical trials. Although such wearables can track a plethora of patient parameters and offer advantages that stand to improve the way in which clinical trials are designed and conducted, they only measure physical parameters of patients and fail to measure biochemical parameters that are directly relevant to drug development (biomarkers). Xsensio has leveraged the most advanced innovations from the fields of nanotechnology, biochemistry, and microfluidics to develop its proprietary Lab-on-Skin™ platform. At its core, the Lab-on-Skin™ platform contains an innovative functionalized sensor chip that is capable of measuring biomarkers in sweat. With the remote, continuous, and real-time monitoring of biomarkers, ultra-low power consumption, and optimized design for mass-production, the Lab-on-Skin™ platform is highly attractive for integration into wearable devices for 24/7 monitoring of patients. In this project, Xsensio will perform a feasibility study to (1) select a panel of biomarkers that maximize the (clinical) applications of the Lab-on-Skin™ platform, (2) obtain quantitative and qualitative market data, (3) construct roadmaps for navigating the regulatory landscape, (4) strengthen and expand its current IP position, and (5) consolidate all current and future findings into a business plan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Influenza Virus - Sugar Interactions, From Glycan Arrays To Better Vaccines' (Sugar-Enable) under Horizon 2020.

assistant: **Objectives**

Our current assays to determine the receptor specificity and vaccine efficiency of influenza A virus fail as they do not represent receptors available in the human upper respiratory tract. The lack of these receptors in our laboratory hosts to create vaccines significantly dampen yields, the resulting mismatched vaccines do not afford proper protection and further drive antigenic drift. The objective of this proposal is to elucidate the functional receptor of human influenza A viruses. By using antigenically drifted viruses, we expect to understand how glycan specificity changes due to immune pressure but it will also lead to the identification of a glycan that is utilized by all human IAV viruses. With this knowledge, better surveillance techniques, culture models and structure-based inhibitors can be developed. Using a novel and sophisticated cell-engineering tool, based on lipidated sugars, we will show functional glycan receptor usage. In addition, I will create cell lines in which human influenza A vaccine viruses grow to high titers without adaptation, thus providing superior protection. To achieve this goal, I propose to enzymatically synthesize complex glycans (AIM 1), including sialic acid modifications that are found on the respiratory tract epithelial cells of humans and other IAV hosts. Several enzymatic methods and glycan array tools are in place, and thus the chance of success is high. I already set-up preliminary methods for the use of lipidated N-glycan structures and extensive knowledge on SEEL is present in the department (AIM 2). For creating super vaccine producing cell lines I will use genetic approaches that previously have shown to be successful (AIM3). The systems dealing with sugars enabling function, either for infection or vaccine research, I