RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Harnessing dendritic cell reprogramming for cancer immunotherapy' (TrojanDC) under Horizon 2020.

assistant: **Objectives**

An important hallmark of cancer is the ability to evade the immune system. Genetic mutations in tumor cells result in the accumulation of tumor antigens (TAs), however, increased cell heterogeneity, downregulation of antigen presentation or inhibition of immune cell infiltration allows immune surveillance evasion. For the first time, direct cell reprogramming offers exciting opportunities to overcome these challenges. My group has recently identified a combination of transcription factors (TFs) sufficient to reprogram mouse fibroblasts into antigen-presenting dendritic cells (DCs), providing a new strategy to set in motion antigen-specific immune responses. I hypothesize that a similar combination reprograms tumor cells into antigen presenting cells (APCs). This proposal aims to test a cancer immunotherapy concept based on DC reprogramming and endowed APC function in tumor cells.The work will proceed in three steps. First, I will define optimal TF combinations and external cues to efficiently reprogram human fibroblasts into DCs employing an innovative single-cell screen. Then, I will reprogram mouse and human tumor cells into tumor-APCs followed by characterization of transcriptome, chromatin accessibility, surface peptidome and ability to present antigens to T cells. Finally, I will test whether reprogrammed cells mount an attack against tumors in mouse models. I will further test the hypothesis that intratumoral delivery of reprogramming factors elicits in vivo antigen presentation, immune cell recruitment and tumor regression.The approach proposed here will combine DCs’ antigen processing and presenting abilities with the endogenous generation of TAs. The induction of DC identity in cancer cells with ability to present a constellation of TAs will open new research a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chemical Transformations in the Inter-Stellar Medium: Photochemical Processes' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Until the beginning of the last century, the scientific convention was that the material in the interstellar medium (ISM) between stars and galaxies was mostly in atomic and ionic form  thus the formation of complex molecules was improbable. Today, however, large complex molecules are being discovered at a dazzling rate  demonstrating the molecular nature of our universe. The physical conditions in the ISM are extremely different than on Earth: in addition to extreme temperatures and low density, there are radiation fields, which, when interacting with atoms and molecules, result in unique chemistry occurring in excited electronic states. This interaction is responsible for many of the chemical phenomena observed in the ISM. Currently, very little is known about the formation mechanisms of molecules in the ISM. The efforts to uncover the chemistry of the ISM are multidisciplinary, yielding experimental, observational, and theoretical results. Theoretical results are crucial for obtaining a molecular-level understanding of chemical phenomena  theoretical results help to guide and decipher experimental and observational results. However, up to now, the toolkit of modern quantum chemistry cannot model the dynamic of large molecules in a highly excited electronic state. The aim of this proposed study is to fill this gap: I will develop new theoretical capabilities within quantum chemistry (specifically, ensemble density functional theory) that will enable us to model the dynamic of highly excited large molecules such as polyaromatic hydrocarbons (which play a crucial role in the chemical evolution of the ISM). The ability to accurately model the dynamics of excited states will significantly advance the field of computational chemistry, giving it the ability to model systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Gender relationships in europe at the turn of the millenium: women as subjects in migration and marriage.' (GRINE), addressing dissemination and exploitation.

assistant: **Impact**

The study will consider how women are becoming subjects of their lives in two crucial fields of action and relationship, i.e. East-West migration and marriage, therefore including the study of women-men relationships. The research aims at understanding recent and ongoing changes in women's life strategies and their imaginaries (subjectivity) as well as in relationships between women (inter-subjectivity) in a European context. The approach combines theoretical, historical and juridical disciplinary competences in gender studies. Great relevance will be given to oral testimonies as a way of evidencing forms of subjectivity, and to explore the elaboration of individual strategies. The partners are chosen in such a way as to represent the North, South, East and West of Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Network of Excellence for Biophotonics' under Seventh Framework.

assistant: **Concept**

Today Biophotonics is an emerging multidisciplinary research area, embracing all light-based technologies applied to the life sciences and medicine. Enhancing diagnosis, therapy and follow-up care, Biophotonics drives the trend towards personalized medicine and plays a crucial role in limiting health-care costs and appropriately addressing the accelerating challenges associated with population aging and the consequent increase in age-related diseases. Its economic and socio-political importance is reflected in the enormous annual growth rates of industries in this field.As a Network of Excellence, PHOTONICS4LIFE aims to provide a coherent framework for research in the strongly fragmented field of Biophotonics in Europe. One of the challenging tasks of PHOTONICS4LIFE is therefore to map and to overview the research and technological developments across these various subdisciplines with their manifold but not sufficiently explored interdependences.PHOTONICS4LIFE targets to bridge the gaps between the different research communities ranging from Physics and Engineering via Chemistry and Physical Chemistry to Biology and Medicine for the analysis of cell processes, for non- and minimally-invasive diagnosis and therapy and for point-of-care diagnostics.PHOTONICS4LIFE aims to link the expertise of research institutes towards the SME's and large companies in order to foster Biophotonics research and to strengthen the economical competitiveness of Europe in the global Biophotonics market.PHOTONICS4LIFE is composed of partners standing on the forefront of Biophotonics research and covering together the broadness of fields including the related ethical issues. The partners will work towards a durable integration, provide a critical mass that will act as a nucleus for integrated fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The relationships between competitiveness, environmental performance and management of Small and Medium sized European manufacturing firms', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

On firm competitiveness the research found no convincing evidence that firms with better economic performance adopt more environmental initiatives, and that economic performance has a negative effect on competitiveness. In all three industries there were small positive effects on employment. The most important obstacle to the take up of initiatives was capital. Also important was the pursuit of other management priorities, and a lack of skills, expertise or advice to adopt initiatives. Attitudes towards the environment were positive, irrespective of the level of environmental performance. Strong environmental performance was not necessarily associated with a strong environmental culture. There is not a shortage of sources of advice for the adoption of environmental initiatives. However, there is a gap between need and demand. External advices are important to environmental performance.The major aim of this research is to identify and weigh the importance of factors which promote and constrain the adoption of environmental initiatives by small and medium sized European manufacturing firms (SMEs). The study focuses on three interrelated hypotheses which recur in the literature, affecting the adoption of clean technologies; these are concerned with: (a) competitiveness, (b) management environmental awareness/culture and (c) external information sources and relationships and linkages to the firm (trade associations, universities, R&D organizations, official government sources, business to business networks, environmental consultants, customers, suppliers etc). The relationship with firm competitiveness is likely to involve positive feedback in both directions: the fact that the firm is competitive may lead to the early adoption of clean technologies while at the same time c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Political centralization, economic integration and language evolution in Central Africa: An interdisciplinary approach to the early history of the Kongo kingdom' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The magnificent Kongo kingdom, which arose in the Atlantic Coast region of Equatorial Africa, is a famous emblem of Africa’s past. It is an important cultural landmark for Africans and the African Diaspora. Thanks to its early introduction to literacy and involvement in the Trans- Atlantic trade, the history of this part of sub-Saharan Africa from 1500 onwards is better known than most other parts. Nevertheless, very little is known about the origins and earlier history of the kingdom. Hence, this grant application proposes an interdisciplinary approach to this question. Archaeology and historical linguistics, two key disciplines for early history reconstruction in Africa, will play the most prominent role in this approach. Paradoxically, if the wider region of the Kongo kingdom is one of the best documented areas of Central Africa from a historical and ethnographic point of view, it is virtually unknown archaeologically. The proposed research team will therefore undertake pioneer excavations in several capital sites of the old kingdom. Similarly, no comprehensive historical study has covered the languages of the Kongo and closely affiliated kingdoms. Nonetheless, the earliest documents with Bantu data, going back to the early 16th century, originate from this region. The proposed research team will therefore undertake a historical-comparative study of the Kikongo dialect cluster and surrounding language groups, such as Kimbundu, Teke and Punu-Shira, systematically comparing current-day data with data from the old documents. Special attention will be given to cultural vocabulary related to politics, religion, social organization, trade and crafts, which in conjunction with the archaeological discoveries, will shed new light on th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Living Therapeutic and Regenerative Materials with Specialised Advanced Layers' (NextSkins).

assistant: **Innovation**

Skin is a living interface with layers of specialised functions (sensing, regeneration, protection). The level of complexity in skins is currently unreached in engineered living materials (ELMs). Here we will create skin-inspired ELMs with layers with living cells, specialised properties and functions. Our living skins are based on a grown matrix hosting engineered multicellular consortia that build and functionalise different layers. Spatiotemporal patterning is realised by genetic control and the physicochemical properties of cells and biomolecules. Our aim is to generate platform technologies to advance biological ELMs and make two proof-of-concept engineered living skins with different applications:We will fabricate a self-encapsulated Living Therapeutic Skin (LTS) made of a bacterial cellulose hydrogel matrix with sense-and-respond cells. LTS will have an interactive layer with sensing functions, a core layer for responsive living cells, and a barrier layer for biocontainment and hydration. An example LTS will be designed to sense pathogenic skin bacteria in eczema and release biosynthesised therapeutic molecules.A dry and tough Living Regenerative Skin (LRS) consisting of biomineralized biopolymers hosting bacterial spores will be fabricated as an alternative to traditional inert materials (ceramics, plastics) in protective garments. The LRS biomineralized core will arrange in microscale layers, like tough biominerals in nature (nacre, bone, dentin). LRS will be encapsulated in an activator shell, engineered to prevent water penetration and to memorize local mechanical experience, giving local self-reinforcement of mechanically stressed regions, a unique property compared to current materials and other ELMs.As a powerful strategy to accelerate the adoption of our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards accreditation and certification of age determination of aquatic resources' (TACADAR), addressing dissemination and exploitation.

assistant: **Impact**

Increase the adoption of working procedures that include quality assurance and quality control mechanisms, for the improvement of stock assessment and environmental management techniques.Objectives:To stimulate the achievement of a higher level of quality within and integration between the member institutions of TACADAR, concerning fish age determination. Description of the work The Institute of Marine Research, Norway, will serve as the coordinating body for the Concerted Action by maintaining the TACADAR Internet homepage, including databases, publishing TACADAR Newsletters and organising annual plenary meetings and workshops.TACADAR will:- Define the framework for the application of quality assurance and quality control mechanisms, to protocols for the determination of fish ages from hard tissues.- Discuss the levels of precision and accuracy to be used as qualifiers in statistical terms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SUstainability-driven international/intersectoral Partnership for Education and Research on modelling next generation CONCRETE' (SUPERCONCRETE).

assistant: **Concept**

SUPERCONCRETE is a synergetic cross-disciplinary international/intersectoral project addressing theoretical models for next-generation concretes, characterised by a significant sustainability enhancement for the construction industry. Three advanced concrete classes (CCs) are selected which represent the projects’ key research lines:- Low-Carbon Concrete (LCC), characterised by non-conventional constituents, often derived from recycling industrial waste or by-products;- High-Class Concrete (HCC), encompassing materials with enhanced performance in strength,  durability;- Fibre-reinforced Cementitious Composites (FCC), with special features on fibre/textile reinforcement and matrix improvement.Developing synergetic through-life multi-scale models for these novel materials is the key objective of the SUPERCONCRETE project. Particularly, three transversal modelling issues (MIs) are considered:- Rheology and Early age, dealing with the various physical and coupled thermo-hygro-chemical phenomena taking place in the first hours after mixing;- Hardened state and service life, approached by constitutive modelling intended at predicting the instantaneous and long-term behaviour, for both service and ultimate conditions;- Extreme conditions, based on constitutive theories capable of simulating the response under fire and high temperature exposure.Each CC and MI is covered by one participant and the interactions among them is based on a matrix-like organisational approach aiming at achieving a true synergistic collaboration among those with specific CC knowledge and the ones bringing in transversal competences on MIs. A further cross-cutting objective aims at defining a  “Sustainability Index”, based on its constituents and processes requested for each CC.SUPERCONCRETE’s final de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantum Mesoscopics with Vacuum Trapped Nanoparticles' to be submitted under Seventh Framework.

assistant: **Abstract**

The objective of this project is to control the dynamics of a nanoscale object with unprecedented precision and to study interactions on the mesoscale, - the grey zone between the discrete atomistic world and the continuous world of macroscopic objects.A single nanoparticle will be captured  by the gradient force of a focused laser beam in ultrahigh vacuum and its center-of-mass motion will be controlled by optical back-action. To cool the nanoparticle to its quantum ground state we will explore  active parametric feedback cooling in combination with  passive cavity-based  cooling.A laser-trapped nanoparticle is physically decoupled from its environment, which guarantees extremely long coherence times and quality factors as high as 10^11 in ultrahigh vacuum. Force sensitivities of 10^(-20) Newtons in a bandwidth of 1 Hz can be achieved, which outperforms other measurement techniques by orders of magnitude. In this project, we will use a laser-trapped nanoparticle as a local probe for measuring mesoscopic interactions, such as Casimir forces, vacuum friction, non-equilibrium dynamics and phase transitions, with unprecedented accuracy.We will also measure the dynamics of nanoparticles in double-well potentials created by two laser beams with closely spaced foci. A pair of trapped nanoparticles defines a highly controllable coupled-oscillator model, which can be used for studying strong coupling, level splitting, and adiabatic energy transfer at the quantum - classical  barrier.A nanoparticle cooled to its quantum ground state opens up a plethora of fundamental studies, such as the collapse of quantum superposition states under the influence of noise and gravity-induced quantum state reduction. This project will also open up new directions for precision metrology and provi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unveiling the dark universe with gravitational waves: Black holes and compact stars as laboratories for fundamental physics' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In recent years, our theoretical understanding of the strong-field regime of gravity has grown in parallel with the observational confirmations that culminated in the landmark detection of gravitational waves (GWs). This synergy of breakthroughs at the observational, technical, and conceptual level offers the unprecedented opportunity to merge traditionally disjoint areas, and to make strong gravity a precision tool to probe fundamental physics. The aim of the DarkGRA project is to investigate novel effects related to strong gravitational sources -such as black holes (BHs) and compact stars- that can be used to turn these objects into cosmic labs, where matter in extreme conditions, particle physics, and the very foundations of Einstein's theory of gravity can be put to the test. In this context, we propose to explore some outstanding, cross-cutting problems in fundamental physics: the existence of extra light fields, the limits of classical gravity, the nature of BHs and of spacetime singularities, and the effects of dark matter near compact objects. Our ultimate goal is to probe fundamental physics in the most extreme gravitational settings and to devise new approaches for detection, complementary to laboratory searches. This groundbreaking research program -located at the interface between particle physics, astrophysics and gravitation- is now made possible by novel techniques to scrutinize astrophysical compact objects, by current and future GW and X-ray detectors, and by the astonishing precision of pulsar timing. If supported by a solid theoretical framework, these new observations can potentially lead to surprising discoveries and paradigm shifts in our understanding of the fundamental laws of nature at all scales.


**Keywords:** black holes, gravitational waves