RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative Chemoenzymatic Integrated Processes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The INCITE project aims to demonstrate novel integrated upstream and downstream processing paths involving flow chemistry and membrane technology in chemo-enzymatic processes. The modularity and flexibility of the developed processes will be showcased through two demonstration cases in real industrial settings and will be using hydrolases for the sustainable, safe and energy-efficient production of commodity and fine chiral chemicals. The first demonstration case involves esterase-catalyzed production of a chiral molecule used as starting material for the production of  insecticides in the field of crop protection and public health, whereas the second demonstration case relates to solvent-free synthesis of oleochemical esters using lipase enzymes. Compared to traditional chemical synthesis processes, these chemo-enzymatic processes have clear advantages of greater efficiency, higher product quality and smaller environmental footprint. Their development to TRL7 will open up the way to their industrialization and thus lead to major positive economic and environmental impacts.


**Keywords:** Chemoenzymatic processes, integrated downstream processing, commodity chemicals, fine chemicals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EUROPEAN NETWORK OF CENTRES FOR THE ADVANCEMENT OF TELEMATICS IN URBAN AND RURAL AREAS' (ENCATA) under Fourth Framework.

assistant: **Objectives**

ENCATA, a pan-European consortium of regional development agencies, supports better coordination of telematics applications in their local small and medium-sized enterprises (SMEs). Project activities in the ten regions concerned are to include a common telematics audit for ENCATA user requirements, telematics action plans as a shared approach and a common information system for development agency users. Telematics support centres in an open networked platform for SMEs will underpin a cluster of cross-sector telematics initiatives in each region. Post-project self-funding of a bigger operation is the ultimate goal.ENCATA is a large consortium of pan-European regional development agencies that aim to promote and assist the usage of telematics in their Regional Small and Medium-Sized Enterprises (SMEs) by co-ordinating and networking their activities in a common, coherent and thus more effective way.  The specific objectives of the project are to develop, verify, evolve and then demonstrate usage of the following in each of 10 Regions represented in the Consortium :-1. ENCATA User Requirements based on a common Regional Telematics Audit, SME Clustering and Needs Analysis.2. Regional Telematics Actions Plans as a shared approach.3. Development Agencies Information System, as a common tool to be used by Development Agency users.4. Telematics Support Centres as an open networked platform tailored to the needs of each Region's SMEs.5. Telematics Support Teams as the key ENCATA coherent implementation approach.The Telematic Support Centres will be building-based and mobile responding to the needs of each region, and they will act as the hub and focus for a cluster of cross-sector telematics initiatives in each region.  The concrete results of the project will be evaluated and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Photocatalysis induced by copper complexes supported on Silica materials-Study in Flow processes' (PhoCuS-Flow).

assistant: **Concept**

PhoCuS-Flow project aims to contribute to the European Research Area (ERA) by developing a new generation of sunlight activated copper photocatalysts supported on mesoporous silica. Three novel concepts are proposed: i) use of tris(triazolyl)methanol-Cu-complexes (developed in the host group) as photocatalysts in organic reactions, ii) the immobilization of the complexes on mesoporous silica materials to be used as heterogeneous and recyclable catalysts and iii) implementation of a continuous flow setup in order to gain in efficiency and potential industrial applicability. These objectives have a direct impact in some of the ‘Societal Challenges’ listed in H2020 i.e. ‘Secure, Clean and Efficient Energy’ and ‘Climate action, Environment, Resource Efficiency and Raw Materials’.PhoCuS-Flow will merge the expertise of the host group in organic chemistry catalysts immobilization and flow processes, together with the background of the applicant in the synthesis of materials, heterogeneous catalysis and management, to reach the desired deliverables and milestones. In addition, a secondment for further specialization in photophysics and photocatalysis has been included in the work plan.An ambitious training program including a number of new scientific and soft skills to be transferred to the applicant is also envisaged. Moreover, the ER will transfer her knowledge to the host groups and will be the link between them to forge future collaborations.Altogether, PhoCuS-Flow will give the candidate a unique opportunity to gain new expertise in different areas of research and new soft skills and leadership capacities. Hence, MSCA will position her at the forefront of the young researchers in the ERA, making possible to reach a position as a group leader at a University in the Europea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Molecular mechanism of the formation of transport intermediates in the post-golgi retrograde transport route'.

assistant: **Concept**

Early endosomes are sorting stations communicating with the plasma membrane ( endocytosis and recycling) and with late endosomes / lysosomes (classical endocytic pathway) . It has been observed the existence of yet an alternative route, from the early endosome directly to the trans-Golgi network, possibly implicating the recycling endosome. Endogenous proteins, such as TGN38, and the B-subunit of Shiga toxin have been shown to follow this route. Its physiological role has not yet been elucidated, but recent evidence has been provided that it is used by signaling molecules such as interferon alpha/beta receptors and CD14 to reach internal sites from where there may signal to their targets. This project aims at the reconstitution of the formation of intermediates of retrograde transport, either from early/recycling endosomes , or in a reconstituted liposomal system. The role of different proteins (SNAREs, coat proteins, cargo) and their functional interactions with membrane microsomains (  rafts " ) will be studied. Our work will reveal the molecular mechanism of protein and lipid targeting into the retrograde transport route and shed light on how lateral lipid asymmetry in biological membranes may influence this process. In addition, it may also lead to the discovery of new therapeutic targets involved in the intracellular transport of signaling receptors and help to optimize the use o f Shiga toxin B subunit as a vector for the intracellular delivery of therapeutics compounds."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'BMX-targeted ligand-drug conjugates for prostate cancer therapy' (LDC4PCaTher), addressing dissemination and exploitation.

assistant: **Impact**

Standard of care strategies for the treatment of cancer still relies heavily on non-specific radiation and chemotherapy. These treatments are commonly associated with severe toxicities and in many cases only offer limited benefit for the patient. The targeted delivery of radionuclides, cytotoxic drugs and pro-inflammatory cytokines into malignant tissue, on the other hand, can markedly improve the therapeutic index and overall efficacy of such substances. Whilst monoclonal antibodies are the most widely used delivery vehicles to date, low molecular weight targeted agents are emerging as a promising alternative to antibody-based drug delivery. These ligands have negligible immunogenic risk and are easier to chemically modify enabling fine tuning of their ADME profile. As a result, it is possible to achieve a time dependent release of the cytotoxic payload at the target tissue maximizing its therapeutic efficacy while producing minimal damage to healthy cells.  Most importantly, depth of tumour penetration and tumour-to-blood distribution ratio after injection should be significantly superior.We therefore propose to systematically investigate the targeting  performance of bone marrow tyrosine kinase in chromosome X (BMX) ligands for the targeted delivery of cytotoxic drugs into BMX-overexpressing tumours, namely prostate cancer. This project aims at (1) demonstrate that a BMX ligand can selectively accumulate in BMX-overexpressing cancers; (2) developing a general chemical approach for building safe ligand-drug conjugates (LDCs); and (3) when site-specifically conjugated to cytotoxic drug, this novel LDC is highly effective for the treatment of prostate cancer. This project is expected to explore new avenues for drug delivery systems since the concepts here proposed go be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Intrinsic motivation to apply renewable energy technologies' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The willingness to bridge the cost gap with non-economical renewable energy systems is explained with the concept of intrinsic motivation. The influence of different institutions on the intrinsic motivation is analysed by comparing empirical data from 3 European countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SIgnals and REgulatory Networks in early plant embryogenesis' in the context of a Seventh Framework call.

assistant: **Objectives**

The focus of SIREN’s network partners within this present project is to train young biologists in using integrated approaches to study and understand SIgnals and REgulatory Networks (SIREN) in early plant embryogenesis at their internationally acknowledged European research sites. The multidisciplinary, interface-oriented approach will give fundamental insight into the regulatory system of early plant embryogenesis and synthesize a plausible descriptive and predictive mathematical model. Early plant embryogenesis represents the first time in plant life that new cell fates are established, and is an excellent model for de novo establishment of meristems, plant stem cell niches. Plant early embryogenesis research has been notoriously difficult to address experimentally. SIREN’s network partners together represent the European critical mass in plant embryogenesis research and now join their knowledge and different technologies such as flow-sorting and microarray technology, sensitive proteomics technology, high-throughput mRNA ISH technology and SPIM microscopy within an exclusive technological platform. The recent identification of a number of key regulators of early embryogenesis provide a unique starting point for an integrated, multidisciplinary and intersectorial approach that will identify the regulatory networks that underlie early plant embryogenesis. Ultimately, these networks will be abstracted by mathematical modeling. Knowledge gained from studying this biological problem will be of high interest for agro-industry in optimizing plant biomass. Furthermore, the integrated approach can serve as a model for similar studies on other aspects of plant growth and development. Last but not least, SIREN’s trainees will get an excellent career perspective through the wide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Core-shell catalysts for Direct Alcohol Fuel Cells (DAFCs): Study of the structure and stability under electrochemical conditions by X-ray structural techniques' in the context of a Seventh Framework call.

assistant: **Objectives**

The development of low-cost materials is a determining step for the final introduction of low temperature fuel cells in the market. These systems, especially direct alcohol fuel cells (DAFCs), are the most important and promising alternative energy systems. However, their commercialisation for demanding applications, in particular for the transport sector, requires an increase of the metal efficiency and the reduction of the platinum content in electrodes in order to reduce the fuel cell cost.In this context, the use of core-shell catalysts seems to be the most feasible solution for reducing the platinum content and, therefore, the fuel cell cost. This nanostructure involves the replacement of the core of the nanoparticles with less expensive metals. Furthermore, using this nanostructure, the utilization efficiency (surface-to-volume ratio) is increased, and an enhancement of the platinum activity is achieved due to an electronic, structural or morphological effect that depends on the metal used as core.In this project, we will explore further enhancements of the alcohol (methanol and ethanol) oxidation activity of core@shell materials for the alcohol oxidation reaction (AOR) by preparing Pd-core, Pt-Ru or Pt@Ru shell catalysts. Subsequently, the studies will be extended to other core metals and ternary (bimetallic shell and/or core) systems. The overall aim will be to provide advance understanding of the structure/property relationships, by using in situ X-ray structural techniques, which determine alcohol oxidation activity as well as identifying the degradation mechanisms that limit the stability of the materials under electrochemical conditions.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Synthesis and characterization of porous molecular solids'.

assistant: **Innovation**

This study aims to explore new porous molecular crystalline compounds and to implement a methodology to study gas-solid interactions at the atomic level using X-ray diffraction methods. New materials for storage, sensing and separation of gases are of significant commercial interest, and our aim is to facilitate the process of materials design by providing tools and methodologies that can be used routinely to understand solid-gas interactions.Research will be focused on the synthesis of new molecular solids as possible porous substrates and the investigation of their structure-property relationships under non-ambient conditions.The methodology implemented in this project will involve sharing of in-house techniques in order to jointly study new materials in a unique manner, primarily by means of X-ray diffraction analysis.The synthesis and preliminary characterization will be performed at the University of Salerno (Italy), physical chemical characterization will take place at the University of Stellenbosch (South Africa), the structural characterization using synchrotron and neutron diffraction at ESRF and ILL (France).Researchers from the University of Salerno and ESRF/ILL will travel to South Africa to carry out physic-chemical characterization, using a gas cell developed at the University of Stellenbosch. South African researchers will travel to Italy to prepare new compounds and carry out specialized crystallization studies. South African researchers will have also the possibility to stay at ESRF/ILL to conduct detailed in-situ structural studies using synchrotron and/or neutron diffraction.The work is expected to yield several publications in top-quality journals, as well as patents on designs of environmental gas cells. Socioeconomic benefits may be derived from th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mutations in healthy tissues: a double-edged sword for tissues homeostasis' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Healthy tissues become progressively populated of clonally expanded cells that have acquired somatic mutations. Often these mutations modify cancer genes promoting cell plasticity, self-renewal, and growth, all features known to decline with ageing. Despite being pervasive across tissues and persistent throughout life, only rarely mutant cells become pathogenic. Here we hypothesise that somatic mutations enhance tissue integrity by increasing the fitness of stem/progenitor cells (SPCs) to counterbalance their age-induced decline. Increased SPC fitness at the cellular level increases the fitness at the tissue level, thus preserving the overall tissue regenerative potential. To test this hypothesis, we propose to investigate the effect of somatic mutations on SPC fitness in solid tissues and blood using complementary and synergistic approaches specific to our teams, bridging the historically distinct fields of evolutionary genetics and stem cell biology. Through the analysis of human tissues and the use of complex mouse models, we will dissect the interactions between mutant SPCs and their niche, at homeostasis and upon insults. We will determine whether the expansion of mutant SPCs over time leads to a progressive decline in SPC diversity, which eventually increases disease risk. We will adopt a progressive approach. We will first characterise the mutant clone (WP1) and its crosstalk with the niche (WP2) at homeostasis. We will then test the response of mutant clone and niche to physiological (WP3) and pathological (WP4) challenges. We will finally assess the occurrence of a multiorgan crosstalk conveyed by mutant blood on mutant solid tissues (WP5). This study will radically transform our understanding of tissue homeostasis and clarify the relationship between somatic m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Delay-Doppler Domain Communications and Radar Sensing' (DDComRad).

assistant: **Concept**

Next-generation wireless networks are envisioned to provide high data rate and reliability with accurate sensing capability. To achieve this, new breakthrough in wireless technology is a must. Conventional wireless technologies are designed in the time-frequency (TF) domain, where the channel response could experience significant fluctuations, and the key radar parameters, e.g., delay and Doppler, are not explicitly represented. Consequently, TF domain communications generally require frequent channel estimation and large signalling overhead, and the communication waveforms need sophisticated adaptions to cater to radar sensing. Recent advances in delay-Doppler (DD) domain signal processing have opened the door for wireless communications and radar sensing in the DD domain. Leveraging the distinct channel features, DD domain communications do not require frequent channel estimation. Moreover, linear delay and Doppler estimation could be possible in the DD domain, thanks to the explicit representations of delay and Doppler. The goal of DDComRad is to fully unleash the potential of communications and radar sensing in the DD domain by developing novel techniques for 1) DD domain multiuser multiple-input multiple-output (MU-MIMO) transmissions; 2) DD domain integrated sensing and communications (ISAC) designs; 3) DD domain pulse shaping and realization. The main research approaches that will be employed include the advanced DD domain signal processing tool, e.g., Zak transform, information-theoretical analysis, and machine learning. The research outputs will have a significant impact on the applicant’s career prospects enabling him to obtain a leadership position in academia or industry. More importantly, the proposed research will not only secure the leadership of the Euro