RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Geneticists for the next millenium' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Most of the milestones are easily verifiable like factual organisation of training courses, workshops and alike. The same is true for the increasing international attraction of the Centre. Economic survival and dynamics of the development of spin-offs can be measured both in quantitative and qualitative ways. And one of the main targets - achieving positive attitude of the public towards genotyping will be quite clear before the end of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From Human Capital to Intelligence Management: Data-driven Economy and Brain-Computer Interfaces' under Horizon Europe.

assistant: **Concept**

Along with artificial general intelligence (AGI), the development of brain-computer interfaces (BCI) is heralded as the new frontier for the data-driven economy. It stands at the forefront of an arms race involving the world’s most valuable companies and powerful states. However, social science scholarship on neurotechnology has largely overlooked core socioeconomic aspects of non-medical applications of BCI, such as their impact on productivity, labour processes, business models, and data extraction schemes. Socioeconomics and critical data studies, on the other hand, have not yet addressed BCI. This research innovates by approaching neurotechnology as a new frontier for data accumulation and exploring how its application in training and work environments connects to a broader societal change wrought by the digital economy: the crisis of the human capital paradigm. It proposes that the demise of human capital is giving way to an emerging alternative paradigm for governing the workforce, defining it as the ‘Intelligence Management Regime (IMR)’ – a new (datafied) ecology of competencies and practices driven by explorations in neuro-enhancement and novel complementarities between humans and machines. At the crux of these developments is a thorough revision of the socially dominant definition of (human) intelligence, which our research will explore. IMR will employ documentary and fieldwork research with major global computational neuroscientific projects, leading neurotech companies, as well as businesses, consumers, and workers using these artefacts in daily activities. In a globalised economy, the investigation requires a comparison of distinct geoeconomic realities where neurotech diffusion is more advanced: the US, Europe, and China. By advancing a new understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Revealing the biological bases of speech and language by studying bat vocal learning' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overarching goal of BATSPEAK is to shed light on the biological origins of speech and language by analysing the molecular mechanisms and neural circuitry that support vocal learning in the bat, using tools that I have pioneered in this species.Vocal learning is a fundamental building block of human spoken language and is a trait we share with few other animals. It has only been identified in 4 non-human mammal groups, of which bats are the only tractable model system in which the molecular and neural mechanisms can be addressed, thus providing a unique window onto the biological foundations from which human speech and language evolved.BATSPEAK has 3 aims:1.To identify the genomic markers of vocal learning allowing us to probe the molecular mechanisms that underlie mammalian vocal learning2.To characterise neural mechanisms underlying mammalian vocal learning3.To determine direct, causative contributions of molecular and neural mechanisms to mammalian vocal learning behaviourThis project will use bats as an exemplar species in which the molecular and neural mechanisms underlying mammalian vocal learning can be understood, and will contain 3 work packages:WP1. Comparative evolutionary genomics, coupled with gene function and gene expression analyses, to identify the molecular mechanisms underlying vocal learningWP2. Comparative neuroanatomy, electrophysiology, and transcriptomics to characterise a key neural circuit underlying vocal learningWP3. Generation of transient transgenic bats to test hypotheses of the role of molecular and neural mechanisms in vocal learning behaviourUnderstanding the bases of vocal learning in mammals will shed light on the biology underlying speech and language and provide a new mammalian model for the study of language related disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MIRACLE the platform for virtual biopsies; introducing Metabolic MRI-as-a-Service for oncologic care' (MIRACLE).

assistant: **Innovation**

Imagine a future where the limitless possibilities of virtual biopsies in cancer diagnostics can be explored. A future in which cancer patients would have access to MRI enabled virtual biopsies in order to receive the best possible treatment decisions anywhere on the globe. MIRACLE is developing a first-of-kind add-on device for MRI scanners that will be used to acquire a virtual biopsy of the tumor providing not only structural information on tumor dimensions for (tissue conserving) surgery, but also unique metabolic information on the efficacy of specific systemic therapies. Ultimately, this fully non-invasive, accurate and rapid predictive approach can guide patients to the best fitting treatment plan given their personal circumstances and tumor characteristics. WaveTronica (WT) together with the University Medical Centre Utrecht (UMCU), German Cancer Research Centre (DKFZ) and Medical University of Lublin (UMLUB) aim to build this future by bringing the first Metabolic MRI-as-a-Service solution to the market. Past projects and research led to the development of a Proof-of-Concept MRI coil capable of detecting metabolic biomarkers non-invasively using the strongest clinically available MRI system, as demonstrated in FET- OPEN-01-2016-2017-801075 - the Non-Invasive-Chemistry-Imaging (NICI) and FET-OPEN-03-2018-2019-2020 - FET Innovation Launchpad - MIRACLE. The MRI coil is a plug-and-play add on for existing MRI machines resulting in an accessible and affordable virtual biopsy tool that can identify cancer biomarkers and tumor activity without shedding a drop of patient blood. This project converts a complex research tool into an accessible diagnostic service (Metabolic MRI-as-a-Service). MIRACLE is supported by the Dutch reimbursement company VGZ, Tesla DC, and oncol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Contactless deformation of metal plates in industry using new high power laser technology', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Traditional methods to bend metal plates are relatively primitive and require processing afterwards. With the new high power lasers it is possible to deform metal plates very precisely. An advantage of the new method is that it prevents unwanted deformation. for thin metal sheets up to 4 mm there are positive results for use in industry. The process is called laser bending. However for thick plates (more than 6 mm), the method fails. The objective of the project is to solve the problems concerning laser bending for thick plates and the development of a prototype for the bending of metal plates with high power lasers for ship and yacht building industry, automotive industry, for prototyping of e.g. car bodies, furniture etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fully integratable lasers and optical amplifiers in silicon' (FILOS) under Seventh Framework.

assistant: **Objectives**

The proposal aims to develop an optimum pre-commercialisation strategy for silicon based light emission and detection technologies developed under the ERC Advanced Investigator Grant SILAMPS (Silicon Lasers and Optical Amplifiers). The university spin-out company Si-Light will be used as the commercialisation vehicle. The company plans to sell licenses to manufacturers in several major market sectors: fully integrated fibre to the home transceivers for passive optical networks, infrared sensors for gas detection, medical products for surgical applications and inter and intra chip communications. We will research the major customers and performance expectations for products in each sector and establish market size and growth expectations. Visits to the most likely licensees will be scheduled to demonstrate the technology.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Open dynamics of interacting and disordered quantum systems' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This research proposal focuses on the open quantum system dynamics of disordered and interacting many- body systems coupled to external baths. The dynamics of systems which contain both disorder and interactions are currently under intense theoretical investigation in condensed matter physics due to the discovery of a new phase of matter known as many-body localization. With the experimental realization of such systems in mind, this proposal addresses an essential issue which is to understand how coupling to external degrees of freedom influences dynamics. These systems are intrinsically complex and lie beyond the unitary closed system paradigm, so the research proposed here contains interdisciplinary methodology beyond the mainstream in condensed matter physics ranging from quantum information to quantum optics. The project has three principal objectives each of which would represent a major contribution to the field:O1. To describe the dynamics of a interacting, disordered many-body systems when coupled to external baths.O2. To perform a full characterization of spin and energy transport in their non-equilibrium steady state.O3. To explore the system capabilities as steady state thermal machine from a systematic microscopic perspective.This will be the first comprehensive study of the open system phenomenology of disordered interacting many-bodysystems. It will also allow for the systematic study of energy and spin transport and the exploration of the potential of these systems as steady state thermal machines. In order to successfully carry out the work proposed here, the applicant will build a world class team at Trinity College Dublin. Due to his track record and interdisciplinary background in many-body physics, quantum information and statistical mechanics combin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Structutal retrofitting of masonry buildings' under Fourth Framework.

assistant: **Concept**

Objective of this proposal is the development of an innovative reinforcement technology for masonry constructions, which could lead to: - a more rapid building rehabilitation procedure, - an increase of mechanical performance of the overall building to horizontal seismic excitation, - at cost not greater than those of existing technologies. For the above reasons the new approach seems to offer both relevant economic advantages for the SME operators involved and for the users, and relevant enhancement for social safety of the communities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Amyloid-β clearance in Alzheimer's disease: Unravelling the role of endocytic pathways of endothelial cells'.

assistant: **Innovation**

Alzheimer’s disease (AD) is an age-associated, irreversible neurodegenerative disorder. Α fundamental neuropathological hallmark of this disease is the accumulation of the amyloid-beta (Aβ) peptide in the extracellular space and its aggregation in the brain. Interestingly, critical role for a healthy brain is played by clearance mechanisms of endothelial cells, which traverse the Αβ peptide through the Blood Brain Barrier (BBB), a highly selective semipermeable border. Studies in recent years have shown that endothelial cells remove Aβ by endocytosis, and that impairment of this function is key to AD progression. However, the exact contribution of the distinct individual endocytic routes, as well as the involved molecular mechanisms, are largely unexplored. Hence, the main objective of ClearPath is to undertake a holistic approach that will shed light into the unexplored endocytic routes involved in brain Aβ clearance and to identify the relationship between endocytic abnormalities and clinical pathologies of AD. To this end, ClearPath aims to: a. develop an in vitro co-culture BBB model system using endothelial and neuronal cells derived from established isogenic hiPSCs; b. screen the distinct endocytic routes to identify their contribution in Aβ clearance; c. undertake bioinformatic analysis of genome-wide datasets from AD patients, to reveal novel disease-associated genes implicated in the endocytic routes; d. use transgenic animal models to validate the role of endocytic pathways in Αβ clearance. The multidisciplinary nature of this project warrants accomplishment of the research objectives, as well as advancement of the research capacity of the Post-doctoral fellow, thus boosting her career in the field. Besides, the results of the study will improve our understand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ECSI awareness reflection network for electronic system design standards' (EARNEST) under Fourth Framework.

assistant: **Objectives**

- Collection of the material to be disseminated in paper and electronic form from ECSI Industrial Members, from other Dissemination Actions, standardisation organisations, user groups and other relevant sources.- Classification of the information to match the target audience needs.- Dissemination of the material to the targeted audience in a packaged and directed form.- Preparation of workshops for European Best Practice projects participants.- Preparation of Executive Digests of the material.- Provision of a coordinated mechanism to access the documentation.- Support of other EC projects, including Application Experiments, Demonstration Projects and other projects supported under the Framework IV Programme, through dissemination activities and consultancy.The awareness of existing Best Practice and modern design and development methods is crucial for European industry products competitiveness in terms of time-to-market, quality and reliability. EARNEST is a European-wide dissemination activity aimed at the promotion of awareness of existing Best Practice, tools, methods and standards in the domain of electronic system design (ESD). It will provide information, advice and promotion of the collected and processed material in order to ensure that European companies, varying from large multi-nationals to SMEs, have appropriate access to Best Practice experience and standards related information.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards a fully decentralized distribution for next generation of travel and tourism distribution' (Biztribution), addressing dissemination and exploitation.

assistant: **Impact**

Currently, air travel distribution (booking and selling of airline tickets and related products) is dominated by an oligopoly of Global Distribution System (GDS) companies. This system, unchanged for the last 30 years, poses a great pressure into airlines profitability due to elevated transactions fees imposed by the GDSs. This concentrated market has resulted in the commoditization of airline contents by third parties and additionally, this obsolete model lacks the flexibility, due to constrains imposed by GDSs, to convey in an adequate way individual offers, limiting innovation and new markets creation in an evolving industry oriented towards air retailing.biztribution reinvents the industry by creating a new revolutionary automated and simple distribution model for the air travel and tourism sector. Based on blockchain Distributed Ledger Technology, we enable airlines to recover governance over their content and customers, creating a shift of paradigm towards a fully decentralized scenario in which flexibility and de-commoditization are achieved, translating into more efficient operations and significant reduction of distribution costs by avoiding overheads and intermediaries.At biztribution we think forward about new ways to understand travel and tourism industry, leveraging technology to create a customer-centric scenario. Our aim is to enable a truly new distribution model based on a collaborative, shared and decentralized model, in which all actors can provide and access content across a distributed blockchain network, resulting in benefits that percolate to the whole industryFor us, the successful implementation of biztribution will have remarkable impact in our company. We estimate, it will bring cumulative revenues of €48,25M by 2023 involving the generation o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biophysics of circulating tumor cells, from single molecule to cell clusters' (BiCiCle), addressing dissemination and exploitation.

assistant: **Impact**

The major cause of cancer-associated mortality is tumor metastasis, a complex multistep process where cancer cells spread within the patient’s body. There is an emerging realization that the fearsome vectors of this cancer dissemination are clusters of so-called circulating tumor cells (CTC) that travel together in the bloodstream where they are subjected to important mechanical forces. Nevertheless, the current knowledge of how these cells are held together is extremely limited. This proposal aims at unravelling the biophysical properties of CTCs clusters from the molecular level to the multicellular level. The applicant Dr Valotteau proposes to use her experience in atomic force microscopy (AFM) to carry out this project under the supervision of Dr Rico who has well-established expertise in high speed force spectroscopy (HS-FS), in collaboration with Dr Pannequin who is a specialist of CTC. This project will be hosted by CNRS in the Laboratoire Adhesion & Inflammation (LAI) which is one of a very few laboratories worldwide equipped with HS-FS, enabling to correlate the characterization of the cell-cell adhesion with the study of the viscoelastic properties of single CTC and CTC clusters over a wide dynamic range physiologically relevant. By gathering complementary resources at the crossroad of cell biology, biophysics and nanotechnology, this BiCiCle project will fill an important knowledge gap about CTC cluster and greatly benefit to the career development of Dr Valotteau. Indeed, this fellowship will provide her a stimulating multidisciplinary environment and topic to set the basis of her own independent research project to become an academic researcher leading in the interdisciplinary field of biophysics.


**Keywords:** Atomic Force Microscopy, Single Molecule For