RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Business-to-Business (B2B)  Business-to-Government (B2G) E-Procurement and Business Intelligence Platform through Smart and Innovative Approaches' (B2B) targeting Horizon 2020.

assistant: **Abstract**

Procurement processes and supplier relations are one of the most significant tasks for a business evident in the phenomenal growth of global markets. As global market grows faster every day, profit margins of companies decreasing and supply chains are becoming more complex. In international markets, companies have to act faster. However, ordinary procurement processes are long and hard to manage. Thanks to potential of cloud based network solutions and enabling mobile technologies, e-Procurement Management System offers an innovative solution by combining e-procurement and tender tracking systems to manage businesses’ procurement processes. This proposal describes a feasibility study of an e-Procurement Management System (e-ProMS).The feasibility study aims to analyse current business opportunities in e-procurement, tender tracking and supplier management cloud solutions. The overall objective of this Feasibility Study is to systematically survey, by means of market studies and customer pilots, the needs and willingness of potential users in order to deploy e-Procurement Management System in the purchasing processes and to demonstrate the advantages of e-Procurement Management System to the companies involved. In the end of the study a global business plan will be conducted. This study will clarify the thinking and perceptions of the industry concerning to Ihale Yazilim’s new and innovative solution (e-ProMS) that provides an excellent opportunity for organisations to help shaping its processes/solutions/database based on global aspects of the next generation e-procurement tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Qualification of Thermal Spray Coatings' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

In various sectors of European industry the lacking of simple, reliable qualification tests inhibits innovative solutions for wear and corrosion problems (using coating technology). Various institutes and industrial laboratories all over the world have developed/are using tests for wear and corrosion testing. However, these are expensive and complex and cannot be used for in-house test facilities needed for production control. Therefore these tests are out-of-reach to most SME's, either for product development, in-house coating production, or subcontracted coating manufacturing. The interpretation of the results of these (scientific) tests for a given set of service conditions requires a physical background, the results of those tests are not capable of producing easy to understand data to select or qualify candidate coating materials, to control coating production, or to predict the behaviour of the coating in practice. The thermal spray coating sector in Europe is characterized by hundreds of specialised SME's delivering coated products to larger companies. During the project simple methods for characterisation and testing of thermal spray coatings will be developed to be used by these SME's. The ultimate goal is to increase the coating quality. Both SME's and larger companies will profit from the results of this project, as the improved quality of local subcontracted spray-coating will contribute to an improved competition of the large European companies on the world market. However, simple tests can only be introduced if these tests are based on a recognized scientific background demonstrating coating performance in relation to material composition and microstructure and processing of the coating. The project outcome will be specific to the following industrial appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Automated, miniaturized and accelerated drug discovery:  AMADEUS' in the context of a Horizon Europe call.

assistant: **Objectives**

The mantra ‘Automation + Miniaturization = Acceleration’ is successfully applied in many research areas and technologies, but not in synthetic chemistry, which is largely believed to be not automatable. However, with the potential to accelerate discoveries while flattening costs, increase safety, streamline data generation, enhance reproducibility, and lower the environmental footprint, automation and miniaturization are two promising approaches to synthesis and are worthwhile to invest in.  I will engineer and validate a comprehensive, technology platform, AMADEUS (Automated, MiniAturizeD, and acceleratEd drUg diScovery), which is able to synthesize in a fully autonomous manner thousands of small molecules per day in nano- or picolitre volumes, based on hundreds of chemistries, efficiently screened and optimized for properties using artificial intelligence. The AMADEUS process will be achieved by interfacing four different modules: a synthetic part based on acoustic droplet ejection technology, coupled with a UPLC MS QC and purification module, and a flexible mounted screening unit. A machine learning module will retrieve and process all relevant synthesis, QC, and screening ‘real-time’ data and automatically guide the iterative optimization cycle.AMADEUS will be showcased with several medicinal chemistry, catalysis, and organic chemistry projects.  With my project, I want to challenge the early drug discovery process, which for over 50 years in pharma companies around the world has (almost uniformly) been pursued and comprises two blocks, 1) a high throughput screen relying on millions of curated and stored compounds and 2) the subsequent hit-to-lead optimization phase often called the ‘design, make, test cycle’. AMADEUS will contribute to the accelerated discovery of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Soft Amphibious MicroRobot fabricated by Additive Integrated manufacturing'.

assistant: **Objectives**

Current healthcare systems are facing major challenges due to the recent global pandemic. The human-human interaction has become hazardous as infection rates rise and healthcare workers are finding increased difficulty in managing the overwhelming number of patients and necessary resources for treatment are constrained. The use of robotic intermediaries for diagnosis and treatment may solve these challenges. The demand for automated medical systems is increasing which can facilitate telemedicine and distribution of individual treatment and care from the limited number of experts simultaneously to multiple patients. Current robotic medical systems are bulky and expensive, limiting use especially for low income counties. Here, soft robotic systems offer several advantages over their conventional and rigid counterparts. They are compliant and can mimic the excellent dexterity of bio-organisms. They can be fabricated by Additive Manufacturing Technology in automated fabrication and thus reduce the cost of the (soft) medical systems. SAMURAI will develop innovative soft microrobotic devices fully 3D printed using additive manufacturing techniques. By using microactuators based on electroactive polymers and ionogels as the movement generating ""limbs"", soft microrobots will be fabricated that can move both in ambient condition and liquid media, resulting in amphibious devices. New 3D printing protocols will be developed and optimized for fabricating the microrobot. Various biomimicking designs of the microrobot will be evaluated. Finally, autonomous operation will be investigated by embedding the soft microrobot with a microchip. The miniaturization of the robotic devices in SAMURAI will pave the way to a future of medical robots traversing the complex micro-channels present
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dynamics of two-component quantum gases', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The computation of dynamical properties (both equilibrium and non-equilibrium) of interacting quantum systems is one of the foremost challenges in contemporary condensed matter theory. Such computations can describe experiments in cold atomic gases, as well as a diverse range of probes in solid-state systems (e.g., inelastic neutron scattering, ARPES, RIXS). The aim of this proposal is to develop a theoretical framework for the study of dynamical properties of two-component quantum gases (TCQGs), systems that are both ubiquitous and under active experimental investigation. This objective will be achieved in four major steps.1. Development of a non-perturbative computational algorithm for integrable TCQGs. Exact results from integrability will be combined with efficient numerical routines to evaluate correlation functions. This will enable the study of large systems, beyond the reach of existing techniques.2. The algorithm will be used to study equilibrium dynamics (spectral functions and dynamical structure factors); results will be compared to predictions from field theory techniques, such as the non-linear Luttinger liquid, and links made to experiments. Analytical study of the attractive gas will examine the role of multiple species of bound states. 3. The non-equilibrium dynamics of TCQGs following a quantum quench will be studied. Numerical results will be combined with analytical insights from the Quench Action framework. Scenarios with no analog in a single-component gas will be accessible, opening a door to new and interesting experimentally accessible physics.4. A numerical framework to treat non-integrable TCQGs will be developed. Using eigenstates of a proximate integrable point as a computational basis, well-tested numerical techniques such as the truncated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of extracellular vesicles in Alzheimer’s Disease: towards obtaining mechanistic insights to intrinsic protection mechanisms' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Alzheimer’s disease (AD) is the leading cause of dementia worldwide (>30 million people). The cause of the disease is not known, and there is no causal treatment. Extracellular vesicles (EVs), including exosomes and microvesicles, are structures released by most if not all cells. EVs carry competent signalling proteins, lipids and nucleic acids, participating in cell-to-cell communication. Recently, EVs emerged as relevant actors in neurodegenerative diseases, especially in AD, and they were described as biomarkers in patient’s fluids. Interestingly, they seem to have a dual role in AD: spreading of pathological aggregates, and neuroprotection against the progression of the pathology. In this project, I will describe in detail the EVs biology in AD elucidating how they act neuroprotective. I will characterise the composition, source and uptake mechanisms of EVs throughout AD progression. I will extract EVs from brains of AD patients (sporadic and familial) and age/sex-matched controls in two stages of the disease. RNA and protein profile will be characterised by novel RNA sequencing and mass spectrometry technics. From these omics analysis, protein and gene candidates related to the EVs functions in AD will emerge. Moreover, to investigate putative mechanisms of neuroprotection in AD, I will treat neural cultures from hiPSCs with AD-derived EVs and stress them with AD-like inputs. The effects of these treatments will be assessed by advanced analysis (i.e. Ca2+ imaging, and mitochondrial trafficking analysis). The endocytic pathways and surface proteins involved in EVs’ uptake will also be evaluated. Finally, AD-iPSC cultures will be used to functionally modify the targets obtained from the omics analysis to foster their neuroprotective role in AD. My project will genera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Plate Observing System Sustainability Phase' under Horizon 2020.

assistant: **Concept**

The future and security of humankind dwelling on Planet Earth depend on our ability to live and cope with the complex Earth system in all its dimensions. Our ability to monitor the surface and subsurface of the Earth and to forecast catastrophic events and their impacts on society is increasingly pertinent as our society develops. Earth system processes transcend national boundaries and the European Plate Observing System (EPOS) brings the solid Earth networks in Europe into a single distributed research infrastructure. EPOS has been designed with the vision and the mission of creating a pan-European infrastructure for solid Earth science relying on novel e-science concepts to provide virtual access to data and services as well as physical access to facilities for a broad community of users. The innovation potential of the EPOS infrastructure involves enabling the use of multidisciplinary solid Earth science data, data products and services relying on national research infrastructures distributed across the whole Europe.  The overall objective of the EPOS Sustainability Phase (EPOS SP) project is to ensure the long-term sustainability of the EPOS Research Infrastructure. This will be done by creating effective synergies among diverse actions dedicated to: (i) secure governance and financial sustainability through the entire research infrastructure lifecycle; (ii) secure technical sustainability and develop innovation to fully exploit data and service provision; (iii) establish and maintain excellence by preserving and reinforcing the trust and awareness of users; (iv) exploit economic and societal benefits to keep stakeholders engaged. The EPOS SP project is timely in the EPOS RI lifecycle because it will consolidate the long-term operational perspective of EPOS ERIC an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Improved clinical decisions via integrating multiple data levels to overcome chemotherapy resistance in high-grade serous ovarian cancer'.

assistant: **Concept**

The goals of this inter-disciplinary project are to 1) gain understanding of the mechanisms causing chemoresistance in high-grade serous ovarian cancer (HGSOC) patients, 2) deliver tools that enable effective and cost-efficient personalised treatment options for HGSOC patients, and 3) commercialise predictive kits & software for treatment response prediction and finding the right therapeutic regimen to the right patient. This project takes an advantage on prospectively and longitudinally collected fresh and blood specimens of HGSOC patients. Longitudinal, multi-layer data are analysed with ML and AI methods to predict patient treatment response and identify the most effective treatment options. Drug screening with patient-derived 3D ex vivo cell models are used to identify drug combination options. Key results will be validated with retrospective cohorts, and in vitro, ex vivo & in vivo models. We will develop an open-source software to visualise all relevant patient-specific data to guide clinical decision-making. Clinically most actionable treatment suggestions will be evaluated in virtual molecular tumour board and translated to patient care.Ovarian cancer kills more than 44,000 women in Europe every year due to lack of effective and long-lasting therapeutic regimens. DECIDER presents an innovative strategy to suggest effective treatments that lead to a marked decrease in ovarian cancer deaths and reduce the number of expensive but inefficient treatments. Our approach paves the way to move beyond the current trial-and-error clinical assessment of drug combinations toward more systematic prediction of the most effective treatments for each patient. The proposed concept will be a major breakthrough in personalised medicine and will benefit individual patients and the h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Retina-inspired ENcoding for advanced VISION tasks' under Seventh Framework.

assistant: **Concept**

The retina is a sophisticated distributed processing unit of the central nervous system encoding visual stimuli in a highly parallel, adaptive and computationally efficient way. Recent studies show that rather than being a simple spatiotemporal filter that encodes visual information, the retina performs sophisticated non-linear computations extracting specific spatio-temporal stimulus features in a highly selective manner (e.g. motion selectivity). Understanding the neurobiological principles beyond retinal functionality is essential to develop successful artificial computer vision architectures.RENVISION's goal is, therefore, twofold: i) to achieve a comprehensive understanding of how the retina encodes visual information through the different cellular layers; ii) to use such insights to develop a retina-inspired computational approach to high-level computer vision tasks.<br/>To this aim, exploiting the recent advances in high-resolution light microscopy 3D imaging and high-density multielectrode array technologies, RENVISION will be in an unprecedented position to investigate pan-retinal signal processing at high spatio-temporal resolution, integrating these two technologies in a novel experimental setup. This will allow for  simultaneous recording from the entire population of ganglion cells and functional imaging of inner retinal layers at near-cellular resolution, combined with 3D structural imaging of the whole inner retina. The combined analysis of these complex datasets will require the development of novel multimodal analysis methods.<br/>Resting on these neuroscientific and computational grounds, RENVISION will generate new knowledge on retinal processing. It will provide advanced pattern recognition and machine learning technologies to ICTs by shedding a new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The development of a DNA fungal probe assay for the diagnosis of opportunistic fungal infections in AIDS/Transplant patients'.

assistant: **Concept**

This proposal aims to develop and test a user friendly kit for the diagnosis and identification of opportunistic fungal pathogens. These are a frequent, and often life-threatening complication in immunocompromised patients e.g. AIDS. Studies show that at least 58-81% of all AIDS patients contract a fungal infection at some stage during their illness, with a mortality rate of 10-20%, and similar incidences and indeed consequences in Transplant patients. Two of the most common opportunistic fungal pathogens prevalent in immunocompromised patients are Aspergillus spp. and Candida spp. Resulting systemic infections incur an extremely high mortality rate and require aggressive therapy. The importance of early diagnosis for effectove therapy, connot be overemphasised. DNA probe technology offers significant advantages over current testing methods in terms of both speed and accuracy. The proposed research will involve the identification and design of specific probes fpr Aspergillus spp. and Candida spp., and the incorporation of the probes into assay formats which will allow the clinician to distinguish between different fungal pathogens. Preparation methods for the extraction of DNA clinical samples will also be examined. After the development of a Kit, it will be necessary to perform extensive clinical trials before its sensitivity and specificity can be guaranteed. Clinical partners will be sought during the exploratory phase to advise on the appropriate formats on the panel of fungal pathogens and to perform phase 1 clinical trials. The partners will include experts in AIDS.HIV and Transplantation fields.