RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ARBOVIRUS SKIN INFECTION MODELLING FOR MORE ACCURATE VIRAL PATHOGENESIS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Although inflammatory and neurological diseases caused by arthropod-borne viruses progress worldwide, biomedical advances are slow, still leaving patients to palliative care. New approaches to arboviral pathogenesis are needed to overcome the limitations imposed by inappropriate experimental systems. Here I propose to use tissue-engineered human skin, comprising immune cells and sensory nerve cells, and naturally-infected mosquitos to investigate infection and cell responses to the Dengue arbovirus. I will benefit from the host organization experience to perform (i) primary and induced pluripotent stem cell cultures and differentiation of dendritic cells, macrophages and sensory neurons, followed by their three-dimensional assembly, (ii) Dengue virus infection of mosquitos and (iii) analysis of cell infection and cell responses using virology, molecular biology and microscopy tools. In return, I will apply my skills in single cell transcriptomics of skin to explore the feasibility to apply this new technology to reconstructed tissue. Thanks to excellent scientific and soft skill training as well as the favourable arrangements provided by the host organization, the deliverables of this interdisciplinary research programme should be attainable in 24 months. In addition, I aim to gain professional maturity by proposing new projects for financing as a result of ideas, knowledge and collaborative links. The demonstration that human sensory neurons are infected by the Dengue virus in reconstructed skin should make an important impact for new biomedical approaches to prevent/treat neurological diseases caused by arboviruses. My objective is also is to have contributed to the progress of the host organization while evolving professionally for a stable employment in Europe.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cell biology of rice aquaporins' (ORYZAQUA).

assistant: **Innovation**

Although they are exposed to ever changing and sometimes challenging environmental conditions, higher plants can achieve remarkable metabolic and growth performances. For this, they have to precisely maintain their water status and failure to do so can dramatically impact their growth and ultimately their survival. The control of water flow in the soil-plant-atmosphere continuum and the fine-tuning of water transport within the plant body represent important mechanisms in these respects. Because of their role in soil water uptake, roots are central during these processes.The project for this fellowship is to develop rice as a model for understanding the function and regulation of aquaporins at the cellular level :1. Aquaporin function and sub-cellular localisation will be investigated in two rice cultivars one upland and lowland, adapted to different watering conditions. Upland rice is grown in rain fed fields prepared and seeded when dry. With respect to this, upland rice can be considered as a classical model cereal, such as wheat or maize. Lowland rice is grown in submersion with water (paddy fields) until ripening. Studying these two types of rice will offer unique opportunity to gain insight about how aquaporin function and sub-cellular localisation can contribute to the adaptation of the plant to two contrasted watering culture systems.2. As architecture of the rice root is complex, we will consider each of the 4 types of roots in our project. One question will be to better understand which type of roots is more important for water uptake and regulation.3. The project will allow identifying the subcellular regulation of rice root aquaporins in response to stimuli such as drought and salt.The present project will target a major crop using state-of-the-art knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Eriete' to be submitted under Fifth Framework.

assistant: **Abstract**

Recent theoretical developments in growth theory have highlighted the importance of institutional factors in the process of technological change and productivity growth. Recent contributions in the field have, for example, emphasized the role of market competition, financial development, regulatory systems and the organization of firms and political institutions, in fostering sustainable long-run growth. At the same time, new growth theories are providing new insights into the reciprocal relationship between technological innovation and institutional and organizational change.The proposed Euroconferences on 'Enterprise Reform and the Institutional Environment in Transition Economies' will attempt to confront the new theories of growth and organization with the evidence generated over the past ten years of economic transition in Central and Eastern Europe and the CS. The proposal calls for three conferences on the following topics:- Competition, Ownership, and Enterprise Performance. - Private Sector Development, Market Selection, and the Credit System.- The Effects of Privatisations on State Interference and the Political Economy of Reforms.The above three conferences will focus on the three key aspects of the interaction between Innovation and Enterprise Reforms, and the Institutional and Political Environment. The emerging theoretical literature in this field can be productively combined with newly available data sets, such as the new 'Business Environment and Enterprise Performance Survey' recently undertaken by the EBRD and the World Bank. The proposed conferences will thus allow a deeper analysis of the two-way relationship between enterprise reform/private sector growth and the evolution of economic and political factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'milkGUARD – a continuous whole milk disinfection system for calf feeding on-farm'.

assistant: **Innovation**

The problem: Dairy farms are continuously aiming at increasing milk yield per cow in the herd. Calf early life nutrition dictatestheir development. Farmers feed a variety of liquid feeds including milk and milk replacers. The state-of-the-art method toreduce the risk of disease spread while feeding milk is to pasteurize it. Though natural milk is the ideal nutrition for calves,the need for pasteurization represents an additional cost of 100,000 €/ year (for a herd with 120 calves). Importantly, on-farmpasteurized milk may still contain measurable amounts of bacteria and the overall procedure is time- and energy-demanding,which hampers wide application amongst small and medium dairy farms.The solution: We at Calvex have developed the milkGUARD solution, which enables the safe employment of optimumnutrition for calves, i.e. natural milk, free of pathogens. The milkGUARD solution combines state-of-the-art methods for fastkilling of pathogens in natural milk. In a three-stage continuous process it disinfects milk with an efficacy of 99.99% - 100%.By providing a system that avoids indirect heating elements and works in continuous, we expect to reduce the operatingcosts to dairy farmers when treating milk for calf-feeding, offering e.g. 30% of energy savings when compared toconventional on-farm pasteurizers.The market: Milk is the EU's main agricultural product in terms of value – approx. 15% of agricultural output – with 160million tonnes of cow’s milk produced in 2014. The EU milk processing industry is a pillar of the European economy, whichcontributes positively to the EU trade balance, bringing over €10 billion surplus. The implementation of the innovation projectwill place Calvex in a strong position to exploit a market potential over five years exceeding €56 million.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New tools and processes for improving machining of heat resistant alloys used in aerospace applications (MACHERENA)' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The main objective of the project is the improvement of tools for the machining of heat resistant aeronautic materials. This improvement will translate into larger tool life, better finishing quality of the part or process speed up. This will involve a significant reduction of the machining costs of these materials, and thus the manufacturing costs of the aeronautical parts.The following processes will be evaluated: drilling, milling and turning. The materials that will be tested are: Ni-Fe alloys, Ni alloys and TiAl intermetallic.The project aims at improving the tools by means of:-redesign of the tools-development and applications of super hard and high toughness nanocomposite coatings-development of advanced machining processes (high pressure cooling machining)The nanocomposite coatings will be optimised at laboratory level on samples with the assistance of its characterization (hardness, friction, wear, adhesion, etc) and surface analysis. The optimised treatments will be applied on the selected tools.The tools performance will be tested both at laboratory level and in industrial conditions: life, failure mode or cooling required will be some parameters that will be tested. Additionally, the failure mechanism of the tested tools will be evaluated, so the optimisation of the tools can be properly oriented. Finally, the tools will be used in the manufacturing of demonstrators, so the developed processes are validated in real working conditions.The results of this project will lead to a decrease in the manufacturing cost of difficult to machine materials, which will increase competitiveness of aeronautical industry. Furthermore, in the case of Ni alloys or TiAl intermetallic a reduction of these costs will allow the inclusion of a higher number of parts manufactured wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Politics of Emotion: Challenging Emotional Regimes in Europe across the Iron Curtain from the 1960s to the 1980s' (POLEMOTIONS) targeting Seventh Framework.

assistant: **Abstract**

This research project will reinvestigate oppositional and countercultural (youth-)movements in Europe from the 1960s to the 1980s, in particular new leftist and post-Marxist groups, new social movements such as squatting, leftwing gay activism and feminism, and the ‘alternative milieu’ in the broadest sense. More specifically, the project examines the ‘politics of emotions’ of these movements and their wider societal and political impact. It analyzes how activists developed a critique of modern, urban capitalism that focused on the emotions capitalist society allegedly produced and prevented. In a way, they thus analyzed what one might call with William Reddy the emotional regime of capitalism. However, by the very act of formulating this critique, they also participated in the creation of this emotional regime. At the same time, their critique allowed them to develop new emotional practices that would break with the emotional regime they abhorred. The research project analyzes both the theoretical critique and the emotional practices of the New Left. It thereby links a history of emotions, the body and the political.Focusing on emotional politics, the project will develop a new paradigm regarding how to conceptualize the transformations of European societies across the Iron Curtain since the 1960s by arguing that new emotional cultures emerged in these decades, to which the alternative left greatly contributed. The project will propose an original interpretation of why especially members of the younger generation rebelled against two seemingly very different socio-political systems, democratic capitalism in the West and state-communism in the East, on similar grounds: a desire for (different) feelings. The project thus seeks to link protest movements of the 1970s in Ea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bioelectrochemical transformation of CO2 for the synthesis of value-added products' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The on-going climate crisis and accelerating production of greenhouse gases such as carbon dioxide has sparked a sense of urgency in the scientific community to come up with solutions to sequestrate and/or recycle CO2. CO2 is a rather stable molecule that needs a high energy input to be chemically activated, and applications to utilize CO2 effectively are still in their infancy, with several research gaps that need to be filled. In this proposal we will use a new biotechnology named microbial electrosynthesis (MES) that has the ability to use a number of aqueous and gaseous wastes, including CO2, and biotransform them into useful chemical commodities. In order to use MES for practical and large-scale applications, utilization of CO2 from exhaust gases should be the target. We will fabricate and use gas-diffusion electrodes (GDEs) enabling microbial catalysts to take up CO2 gas directly and more efficiently, solving the problem of low CO2 solubility in aqueous media and mass transfer limitations. This project will develop a novel dual biocatalyzed MES consisting of an efficient gas diffusion biocathode for CO2 sequestration in combination with a bioanode for simultaneous product valorization from glycerol, using different biocatalysts, including enriched and engineered synthetic communities. The use of microbial catalysts both at the anode and cathode will significantly increase efficiency and product specificity of the MES system, which is low with chemical catalysts. Furthermore, the application of a bioanode based on oxidation of a cheap industrial by-product such as glycerol, not only generates higher energy electrons for the GDE biocathode saving energy, but also leads to production of added value compounds, making the process more energy and cost efficient.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'First European Aeration Systems based on NANOBUBBLES TECHNOLOGY for Waste Water Treatment' to be submitted under Horizon 2020.

assistant: **Abstract**

Clean-up of waste waters has a huge environmental footprint, in terms of energy consumed and impact on the ecosystem.Public and private organizations operating WWT plants (Waste Water Treatment) face problems in terms of: 1) highoperating costs for electricity consumption and maintenance; 2) high costs of devices for the upgrade of osolete water aeration systems. LUNA is the is the first company in Europe having developed, tested and demonstrated in real conditions a NBG (Nanobubble Generator) aeration system able to treat huge flows of WWT, with revolutionary properties: A) high aeration capacity (hyper-aeration): transfer of larger amounts of dissolved oxygen in to the waste water for the biological treatment processes, which means higher efficency.B) hyper-oxidation properties, which help to remove various harmful chemical elements (ammonia first of all) in wastewater and reducing the sludge produced in comparison with traditional processes. LUNA’s WMAX Nanobubbles aeration system is currently the best and chepaest available solution to upgrade the aeration system of obsolete water-treatment plant. For building a new aeration system WMAX devices are the best solutions that guarantees simultaneously low costs for purchase, installation and maintenance, very high efficiency, simplicity and speed of installation. After extensive lab tests, in mid 2018 the first (WMAX-50) device has reached the TRL7, after six months of continuous tests in real conditions at a pilot users’ WWT plant in Italy. To bring the WATERmax technology on the market, the company foresee the following actions: i) optimize the first prototype (WMAX-50) and prepare staff for its industrialization and productionii) develop the new bigger WMAX-200 and plan new (big/small) modelsiii) certify (CE) WMAX an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Flexible Mini-Factory for local and customized production in a container' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Advanced production equipment and innovative systems are needed to enable fast and cost-effective manufacturing of  customised products at the location of need, at the required time.Within CassaMobile a mobile, flexible, modular, small-footprint manufacturing system in a 20’ ISO-container that can be easily configured for different products and processes is developed. The container format allows transport to provide on-site manufacturing anywhere, enabling the benefits of localised service delivery without duplication of equipment at multiple locations.The integrated modular manufacturing system with standard interfaces allows an easy exchange of process modules. The process modules are inherently intelligent. Each module is equipped with its own control equipment and features a self-description, which in combination with the machine control system allows automatic configuration of the whole assembly system.An additive manufacturing module enables the system to “3D print” customised components of virtually any shape. In-process inspection improves accuracy, reduces waste and eliminates manual quality control tasks. A pick and place module allows assembly of discrete components. Other processes, such as finishing, cleaning and sterilisation, can be easily integrated as additional process modules.The concept will be demonstrated by three use cases: bone drill guides for orthopaedic surgery, medical orthotics and individual industrial gripping products. The use cases impose very different and challenging requirements for customisation: patient-specific parts, medical production, high demands for process stability etc.The project will create significant impact by enabling manufacturers to respond to rapidly changing market dynamics with high value-added products whilst redu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel compounds that inhibit the activation of CD4-positive T cells as immunosuppressive agents' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The present proposal foresees the synthesis of peptides and, in the following, of peptidomimetics corresponding to a discrete, non-polymorphic domain of major histocompatibility complex (MHC) class II molecules. On the basis of theoretical considerations and preliminary results such compounds are expected to interfere with the antigen-specific activation of CD4-positive T cells through a novel mechanism of action. Thus, such peptides should not act through occupation of the antigen-binding groove of M:HC class II molecules nor through inhibition of the binding of CD4 coreceptors to MHC class II molecules.  Preliminary results have shown that linear, up to 16 amino acid long peptides corresponding to said domain, are indeed able to inhibit antigen-specific T cell activation as determined by measuring proliferative responses in mixed leukocyte reactions (MLR) and of T cell clones in response to their specific antigen. Further studies showed that the active peptides affected CD4-positive, but not CD8positive T cells. Reduced proliferation was paralleled by reduced production of interleukin 2 (IL-2), the main growth factor responsible for proliferation of activated T cells. On the other hand, no significant modification of the up-regulated expression of highaffinity IL-2 receptors was observed. These results are consistent with the hypothesized mechanism of action. More direct evidence in favour of this was obtained, on living cells, with a novel imaging technique.  The work programme foresees the synthesis of other peptides that will be shorter than the parent compounds and of constrained chemical structure. Further peptides and peptidomimetics will be synthesized having properties that should make them suitable for in vivo administration and, eventually, as pharmacologica