RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advances in epidemetric parameters of zoonotic cutaneous leishmaniasis to validate tools for surveillance and control' (1998-2002).

assistant: **Innovation**

This proposal is related to zoometric coetaneous leishmaniasis (ZCL) which remains a serious unresolved public health problem worldwide. The project consists to refine the validity of classical (leishmanin skin test) and new (antibodies to sand flysaliva, cytotoxic Tcell response) parameters for a better understanding of thepathogenesis of L. major infection and to develop mathematical models for the prediction of the dynamics of infection and the outcome of control measures. The study design consists of a prospective population study of individuals living into different ZCL foci. The effect of host-related factors on the clinical expression of the infection will be assessed considering environmental factors. This will permit a better knowledge of key parameters governing dynamics of infection and will prepare the ground for better evaluation of anti-leishmanialdrugs and vaccines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Symmetries and Degrees of Freedom in Cosmic Epochs of Accelerated Expansion' (SymAcc).

assistant: **Concept**

Through theory and observations, it is well established that the universe undergoes accelerated expansion in its history. This accelerated expansion takes place in two different epochs. The first of these is the early epoch of inflation and the second is the current epoch of dark energy domination. Although methods of General Relativity, which is the classical theory of gravity, and Quantum Field Theory, which addresses matter interactions at quantum scales, have guided much of our understanding of the universe, they cannot fully address these epochs of accelerated expansion.In this project the objective is to identify the cosmological degrees of freedom that have a crucial role during inflation and dark energy. It proposes to achieve this goal by studying the ideal case of a spacetime that gives accelerated expansion, using recent methods in holography in order to (i) identify specific deformations from the ideal case that give rise to the cosmological degrees of freedom during inflation and dark energy separately; (ii) explore the generality of these deformations and their cosmological consequences using methods of renormalization group flows; (iii) address deformations in the context of time dependent and space dependent evolution separately to further improve the understanding on the nature of cosmological degrees of freedom.This interdisciplinary project proposes to use the principle of holography from String Theory which can open up a new way of studying cosmological perturbations, especially in the context of dark energy. By focusing on cosmological spacetimes, it will also address the validity of holography in new settings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Strongly Correlated Physics and Materials for Energy Technology'.

assistant: **Objectives**

Materials where conduction electrons experience strong correlation in their dynamics, are both a challenge to the current quantum theories of matter and a mine for possible technological applications. High-temperature copper- and iron-based superconductors and heavy-fermions with large thermoelectric responses are examples of materials with high potential impact on energy transmission and storage technologies or high-magnetic field applications. Recently, the discovery that the well known atomic ""Hund's rules"" have a surprisingly great and diversified influence on the conduction electrons in d-electron materials changed the traditional view of electronic correlation as a competition between kinetic energy and Coulomb repulsion, adding Hund's exchange energy as a third axis. This project, by using state-of-the-art computational techniques for correlated materials, aims at clarifying the influence of the new Hund's driven mechanisms as possible enhancers of high-Tc superconductivity and of thermoelectric and thermomagnetic properties.In particular Hund's coupling can induce the coexistence of weakly and strongly correlated conduction electrons, culminating in orbital-selective Mott insulating states or in heavy-fermionic physics. We then aim at the creation of a new class of transition-metal (d-electron) compounds reproducing the properties of the more exotic rare-earth (f-electron) heavy-fermion materials, in a tunable way. Iron-based superconductors exhibit some of these properties and will be used as a starting point for the search and exploration of new and enhanced high-temperature superconductors and thermoelectric/thermomagnetic d-electron materials.  An exciting application is also proposed, motivating a possible resurgence of technological attention towards the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Longitudinal Investigation of Visual and Numerical Perception in Preterm and Full-term Infants' (PrePER) targeting Horizon Europe.

assistant: **Abstract**

The number of preterm births is on the rise -now more than 1 in 10 babies- and being born preterm is associated with having difficulties in two very important and related cognitive skills that we rely on daily: numerical and visual perception. However, a knowledge gap exists on neural and behavioural associations of numerical and visual perception in full-term and preterm infants. PrePER aims to uncover the underlying neural signatures of the cognitive dysfunctions that preterm infants might display in the first year of their lives and the role of parent-baby interaction to predict preterm infants that are at risk of developing these cognitive difficulties in the second year of their lives. The purpose is to establish criteria to identify infants (especially preterm) at-risk of having cognitive difficulties in numerical and visual perception. Shedding light on normal and impaired cognitive functions in infancy is an essential stepping stone that will pave the way for early diagnostic tools and interventions that would correct the cognitive dysfunctions more efficiently while the brain is still developing. The activities in PrePER will lead to original and innovative outcomes that are beneficial for four parties: 1) Scientific communities will be interested in the results as the ambitious research objectives address questions that have not been asked before. 2) Parents of preterm infants, health-care providers, and policy makers will be interested in the results as the overall aim is to establish criteria to identify infants at-risk of having cognitive-developmental difficulties in the first year of their lives. 3) The researcher will be accelerating her career progression as the training objectives meet her specific needs. 4) The supervisor will be enlarging her researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of UV-B radiation in Aquatic Terrestrial ecosystems an experimental and functional analysis of the evolution of protective and adaptative mechanisms in plants' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

It is exspected that enhanced solar UV-B radiation on earth will remain however for at least another 50 years. Since increasing short-wavelength solar ultraviolet-B radiation (280-320 nm) is potentially damaging to all living organism UV- B research has focused on human health and on UV-B damage in plant and animals. UV-B radiation may damage DNA and one of the major lesions are thymine dimers, which inactivate DNA, if not repaired. At a sufficiently high PAR-UV-A/UV-B ratio an enzyme, DNA photolyase cleaves the thymine dimers and restores the original DNA strand. In plants, exposed to (enhanced) solar UV-B radiation UV-B absorbing compounds are induced. These UV-B absorbing compounds act as UV-B screens and recuce levels of UV-B in plant tissue and cells, and may thus prevent dimer formation. There is evidence that in previous times UV-B on earth has been much higher than at present. Along with changes in the composition of the atmosphere and stratosphere, evolution of plant and animal life took place. In the early, primaeval atmosphere, lacking stratospheric ozone and high fluxes of UV- radiation on the earth surface, life was restricted to aquatic ecosystems, where the filtering of UV-B by the water column prevented UV-damage to living organisms. In the evolution of terrestrial plant life from marine and fresh water plant life, evolution of UV-B absorbing ((poly)phenolic) compounds is assumed, acting among other functions as UV screens. From lower to higher plants there seems to be an increasing degree of complexity of UV-B absorbing (phenolic) compounds. It remains uncertain whether an early, developing stratospheric ozone shield allowed aquatic plants to emerge and evolve to terrestrial habitats, or that the evolution of UV-screens (consisting of UV-B absorbing (ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synthetic Circuits for Robust Orthogonal Production' to be submitted under Horizon 2020.

assistant: **Abstract**

The repertoire of industrially produced fine chemicals in various biological systems will rapidly expand using the tools from the emerging field of synthetic biology. However, the high-level production of non-natural products or de novo activities through synthetic circuits compromises the integrity of host organisms, which significantly impacts or even prevents the development of an industrial pipeline. Our ability to exploit the potential of synthetic biology for industrial production is constrained by our understanding of the integrated cell response when introducing a new synthetic circuit into the homeostatic network of the cell. SynCrop’s main goal is to establish a European Training Network that merges the fragmented scientific expertise in theoretical, experimental and application-driven quantitative biology to educate the next generation of researchers to construct modular and tunable synthetic circuits and foster the development of novel production platforms for food additives (e.g. vitamins, carotenoids and exopolysaccharides). Researchers with inter-disciplinary skills in both experimental and computational biology are needed to solve complex application-driven problems. SynCrop brings together ten academic partners from quantitative biology, cell engineering, microbial physiology and mathematical modelling fields and six industrial partners, including key experts in metabolic engineering and industrial biotechnology. The consortium will provide 15 early-stage researchers with cutting-edge multi-disciplinary research training, through tailored research projects, rigorous exchange of expertise among researchers and partners, and participation in specialised courses, workshops and conferences augmented by extensive training in complementary skills. SynCrop wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Supramolecular Biomedical Materials' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Nanostructured functional materials are undoubtedly one of the main focal points in academic and industrial research communities. Nature’s own ‘bottom-up’ strategy for the construction of immensely complex and sophisticated nanoscaled systems have served as an inspiration for ground-breaking developments in the field of supramolecular chemistry. I aim to combine self-assembly and self-organization for the fabrication of complex supramolecular systems with specific functionality. I propose to use peptide discotics for the controlled self-assembly of supramolecular functional nanoparticles in water and target molecular imaging studies in order to develop Supramolecular Biomedical Materials.I will establish a set of semi-empirical rules, a packing parameter, for the design of supramolecular colloidal particles. The strategy of frustrated growth will aim to balance out positive non-covalent interactions with repulsive forces. Thereby the growth, stability and biocompatible surface functionalisation of the architectures can be controlled, aiming at sizes below 20 nm. The resulting supramolecular materials will be applied in molecular imaging, the development of nanoparticulate targeted and multimodal contrast agents.The elegance and uniqueness of these Supramolecular Biomedical Materials is that following the initial targeting event, the self-assembled scaffolds will disassemble into their small building blocks. This optimises secretion by the renal system and at the same time, the highly ‘effective’ imaging is also retained because of the high local concentration of the imaging agent, thus enhancing overall contrast, sensitivity and resolution of for example cardiovascular disease processes. This will significantly reduce the residence times of the targeted agent, which is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The development of a vaccine against mucosal infection with SIV/HIV in non-human and human primates'.

assistant: **Concept**

Mucosal infection with simian immunodeficiency virus (SIV) can be prevented in non-human primates by immunization with recombinant SIV gp120 and p27 in alum. This was established in the first EU sponsored Concerted Action and will be published in Nature Medicine (Lehner et al 1996). To pave the way to human application, rectal and vaginal mucosal immunization has been successfully performed with cholera toxin B (CTB) subunit (Czerkinsky et al 1995). These findings offer a firm pre-clinical and clinical baseline which we wish to develop. The present proposal addresses 3 principal objectives in developing a preventive vaccination strategy in humans.(1) To develop the most effective and simplest route of delivery of the vaccine, using targeted iliac lymph node (TILN) immunization as a basis for comparison of protection, immunity and viral load. (2) To elucidate the mechanism of protective immunity, by examining B and T cell responses at 3 defined barriers: the recto-genital mucosa, iliac lymph nodes, and spleen with the circulating blood. (3) To generate recombinant antigens in plants so as to enable a cost-effective vaccine to be produced on an agricultural scale. The deep subcutaneous (SC) delivery required for TILN immunization in macaques will be first modified into conventional SC and/or IM injection with the aid of lymphoscintigraphy. The alternative direct rectal and vaginal immunization will be explored utilising a number of mucosal receptors. Fcg and C3b receptors enable immune complexes to bind to these receptors, and GM1 enables CTB-HIV-1 constructs to bind to the mucosa and to be interiorised. Recombinant immune complexes, as well as HIV gp120, p24 and nef antigens will be generated in transgenic tobacco plants, with the potential of large scale production, of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Novel insights into sex-specific and oestrogen-dependent mechanisms in myocardial ischaemia/reperfusion injury'.

assistant: **Innovation**

Acute myocardial infarction (MI) accounts for millions of morbidity and mortality cases worldwide. While the underlying pathophysiology of cardiomyocyte dysfunction and death during MI-related ischaemia/reperfusion injury (IRI), which occurs due to the restoration of coronary blood flow after MI, is well established, the relevance of sex-based differences in this context is poorly understood. In this action, we aim at understanding the effect of biological sex in the induction of a novel form of cell death in the setting of IRI. The project will examine both mouse and human hearts and will benefit from a range of techniques including, but not limited to in vivo surgery, in vitro cell line evaluation, state-of-the-art microscopy, mitochondrial respirometry and molecular biology methods. The content of the action will enable the researcher to restart his career and gain important academic, interpersonal and laboratory skills. It will also provide an opportunity for the researcher to publish in major journals and disseminate his findings to scientists and the public, which will ultimately help him establish himself in the field of cardiovascular science. The action also helps raise the research and academic profile of the host team and institution and contribute to the development of strong intra-European science networking. Overall, this action aims at contributing to the scientific progress of the researcher and pave the way for the identification of novel therapeutic targets for IRI with direct translational potential.


**Keywords:** cardiac,  cell death,  mitochondria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of sensor-based Citizens' Observatory Community for improving quality of life in cities'.

assistant: **Objectives**

CITI-SENSE will develop “citizens’ observatories” to empower citizens to contribute to and participate in environmental governance, to enable them to support and influence community and societal priorities and associated decision making. CITI-SENSE will develop, test, demonstrate and validate a community-based environmental monitoring and information system using innovative and novel Earth Observation applications.To achieve this, the project will: (i) raise environmental awareness in citizens, (ii) raise user participation in societal environmental decisions and (iii) provide feedback on the impact that citizens had in decisions. It will address the call’s request for effective participation by citizens in environmental stewardship, based on broad stakeholder and user involvement in support of both community and policy priorities. The project aims to learn from citizen experience and perception and enable citizenship co-participation in community decision making and co-operative planning.The concept of CITI-SENSE rests on three pillars: technological platforms for distributed monitoring; information and communication technologies; and societal involvement. Three pilot case studies will focus on a range of services related to environmental issues of societal concern: combined environmental exposure and health associated with air quality; noise and development of public spaces, and indoor air at schools. Attention will be given to representativeness of citizen participation. The case studies will be designed in collaboration with citizens’ groups and decision makers. They will be based on distributed data collection using innovative static, portable and personal devices (low-cost reliable microsensor packs) that communicate with a data repositories through mobile phones