RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigation of the possibilities and development of a model for reconstruction of heating systems in small towns and villages. pilot project in couties of east-and west-virumaa', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The goal of the project is to work out the program of reconstruction the heating systems in all region of Northeast Estonia, with modern technologies of: firing the fuel and modern equipment. Special attention will be paid for working out and implementation of new technologies of using the local fuels, among them fuel oil, which is unique resource in all Europe, and which is exported to a number of European states. Implementation of the program of reconstruction, is allowing to elevate the effectiveness of combustion the fuels in Estonia and in the other European states, which are using the Estonian fuel oil, reduce the cost of heating, increase the level of life-comfort, decrease the pollution in Estonia and in other European countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multi-disciplinary training environment for next generation hydrogel-based smart bio-interactive materials' in the context of a Seventh Framework call.

assistant: **Objectives**

Smart resorbable hydrogels will play a key role in next-generation biomedicine, for instance as platform materials for tissue engineering. As these materials have potential to address a wide range of medical conditions, significant growth for the biomedical materials industry is forecast. To explore this opportunity and exploit the potential, highly-qualified and well-trained biomaterials experts are urgently required. NeoGel will address this need by providing cross-disciplinary training to four ESRs in an exciting academia-industry collaboration focused on novel hydrogels.In this EID, two leading academic and industrial groups in polymer and biomaterial science, complemented by associate partners in pharmacology and tissue engineering, will apply an integrated approach to the development of new biomaterials. This will comprise iterative improvement of commercial and of novel-hydrogels, providing the ESRs with an ideal, rapidly developing, environment in which to learn. The training environment will be supported by structured training in transferable skills, covering entrepreneurship, project management and communication, delivered by private sector and university specialists. In a unique approach NeoGel will link up with another Marie Curie ITN and with an Irish structured PhD programme, for training in biotherapeutics.The training provided will match the anticipated skills required by the next generation of research leaders in the biomaterials/regenerative medicine industry. The ESRs will emerge with excellent scientific skills and with intuitive understanding of the needs of industry and of conducting industrial projects. They will have rapidly matured through the programme and will graduate fully able to operate in commercialised research environments. Hence they w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Genetic analysis of mechanisms linking cell wall integrity with growth control in Arabidopsis' (CELLWALLSIGN) under Seventh Framework.

assistant: **Objectives**

Sugars, as a resource of energy and structural components, regulate many important cellular processes. In photosynthetic and sessile organisms like plants, maintenance of sugar homeostasis requires complex regulatory mechanisms. In recent years, a pivotal role for sugar as signalling molecules has become apparent and many efforts have been done to study the molecular mechanisms of sugar regulation. Recently, isolation and characterisation of the high sugar response mutant 8 (hsr8) revealed a link between sugar sensing and cell wall integrity pathways. The hsr8 mutant was isolated because it displayed, in response to sugar levels, increased dark development, increased sugar-regulated gene expression, increased starch and anthocyanin levels and reduced chlorophyll content (Li et al, 2007). The hsr8 mutation was mapped in the gene encoding the first enzyme of the arabinose biosynthetic pathway. This suggests that the defect in the cell wall composition is sensed, transduced to the nucleus, and lead to altered glucose-responsive growth and development. Genetic analysis demonstrated that the Pleiotropic Regulatory Locus 1 (PRL1) was one component of this cell wall integrity pathway. The aim of this proposal is to use a combination of genetic and biochemical approaches to identify components of the cell wall integrity pathway and to establish the relationships with sugar-responsive and growth control pathways. The first strategy will consist in a genetic screen to isolate suppressors of the hsr8 mutation and the second strategy will aim to further investigate the role of PRL1 and its putative partners in the cell wall integrity pathway. In a context of decreasing oil resources, cell wall polysaccharides are expected to play an important role in biofuel production. The knowled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SERS –tweezers enhanced by electro-thermo-plasmonic flow' to be submitted under Horizon Europe.

assistant: **Abstract**

Direct quantification of dopamine neurotransmission is one of the unsolved problems that engaged scientific minds for the last fifty years. Such quantification is an extremely important tool to understand the underlying pathways that promote neurodegenerative diseases like Alzheimer's and depression. Since dopamine is secreted only in micro-molar quantities, a novel signal-amplification technique is required to be able to appropriately quantify its concentration. To meet the challenge, we propose a multidisciplinary research program comprised of simultaneous measurements from laser tweezer Raman spectroscopy and fluorescence emission spectroscopy. Our proposal is based on the strong plasmonic interaction between graphene oxide nanosheets and aptamer functionalized gold nanoparticles, which increases the local intensity of the electromagnetic field to an extent that minute changes in ambient dielectric constant due to variations in the concentration of dopamine could bring about a perceptible signal. In the suggested scheme, we will use optical tweezers to place a gold nanoparticle dimer close to the surface of a graphene oxide sheet, and their hybridization will give rise to very strong electromagnetic fields able to dramatically increase the optical emission from dopamine. Moreover, we will increase the local concentration of molecules with electrothermoplasmonic flow towards the sensing area. The SERSET project will be carried out in the Nanoparticle Trapping Lab at the University of Granada, where a state-of-the-art setup combining optical tweezers and confocal Raman spectroscopy is available. A microfluidic chip and theoretical calculations will be carried out in the group of Prof. Romain Quidant at ETH Zurich during the planned secondments. The candidate has a stro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Self-Powered Skin Patch for Cystic Fibrosis Diagnosis' to be submitted under Horizon 2020.

assistant: **Abstract**

Cystic fibrosis (CF) is a genetic autosomal recessive disease, which induces mutations on a conductance transmembrane regulator protein (CFTR) that controls the exocrine system responsible or producing saliva, sweat, tears and mucus. The protein malfunction affects severely the lungs and digestive system. Patients with CF present also higher chloride contents in sweat than healthy subjects, so chloride testing in sweat has become the gold standard test for CF confirmation after new-born screening blood tests. However, tests on new-borns are not 100% sensitive and not universally stablished along European territory, which leads to patients with a late diagnostic that decreases their life quality and expectancy. The ‘sweat test’ requires either sophisticated analytical procedures or costly commercial analyzers and consumables that restrict the availability of the test to few specialized units scattered along the European territory. POWER-PATCH aims to evolve and promote the value of a novel, market disruptive patch that enables an affordable and easy-to-use sweat test for the screening of cystic fibrosis. The patch has been conceived to be applied on the forearm of the patient and yield a “positive” result in case of an abnormal conductivity level of sweat is detected. It combines the low cost and easy handling of paper that is associated with the filter paper-based diagnosis technique and at the same time allows obtaining a digital response with no further handling or treatment of the sample. Moreover, as it already contains a “battery sensor”, sweat collection and testing does not require additional equipment and can be easily taken to any clinical environment. Within this ERC PoC project, we aim to achieve (i) Technical validation and Clinical testing in a specialized
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The application of Protistan diversity and community analysis, an integrated approach to Water Quality Assessment' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The urgent need for robust, high-throughput method to assess water quality and aquatic biodiversity, as a proxy for environmental health, are clear. This provides an obvious target for initial efforts resolving molecular fingerprints for total diversity and identification of potential indicator organisms. Eukaryotes exhibit a significant level of morphological diversity that has traditionally been used to define Linnean names. Molecular systematics provides a separate and powerful tool for phylogenetic analysis but does not link easily to the system of Linnean names, especially for environmental molecular studies. This project seeks to provide Dr Gong with an array of molecular skills to compliment his expertise in ecology and traditional systematics that will position him to lead a research group to address this problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Unraveling the Photochemistry of Radiosensitizers and Radioprotectors in Free Biomolecular Complexes'.

assistant: **Objectives**

Dramatically increasing cancer cases around the world call for extra research efforts to improve cancer therapies. Radiation therapy or radiotherapy is one of the most common treatment methods. A way to enhance radiotherapy is inserting radiosensitizers (RSs) and radioprotectors (RPs) into the patients body. RSs in tumor cells make them more sensitive to radiation damage, allowing one to use reduced radiation doses, thus minimizing side effects. In contrast, RPs inhibit the damage of healthy cells from radiation. RSs and RPs are actively studied mostly in clinical trials. However, the fundamental mechanisms causing damage or death of cancer cells are not fully understood. Therefore, this project aims at elucidating the elementary steps of radiation damage, their enhancement by RSs, and their inhibition by RPs. The technique combines beams of mixed molecular clusters and doped helium nanodroplets uniquely with synchrotron spectroscopy, electron spectroscopy, and ion mass spectrometry. The main goals are to unravel the photochemistry of selected organic RS compounds (nimorazole, NIMO, bromoadenine, WR-1065 dihydrochloride), metal ions (Mg2+, Ca2+, K+), and gold (RS) and silver (RP) nanoparticles in the state of controlled microhydration and contact with DNA components (thymine, cytosine, tetrahydrofuran). Emission of slow electrons, water fragmentation, and anions formation are observables for radiation damage enhanced by RSs. A time-resolved experiment on the tetrahydrofuran-water complex will elucidate the ultrafast dynamics of intermolecular energy transfer causing dissociation, a mechanism recently identified to play an important role in radiation damage. A better understanding of the radiochemistry of RPs and RSs obtained with this project may help develop new scheme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The SAfer FUEL system'.

assistant: **Concept**

Fuel Systems (FS) are critical for aircraft safety. Fire, ice and system failures are typical safety hazards associated to FS. FS accidents, though only representing 2% of accidents/incidents, continue to be a recurrent concern, especially as: the complexity of FS escalades to cope with increasing needs, including more stringent safety requirements ; flight conditions evolve with new routes at high altitude, crossing the Arctic, and faster climbing and approach; climate changes with more aircraft (A/C) exposed to hazardous weather.Thus, FS have to deal with more extreme temperatures, stronger temperature gradients, more humidity, and more exposure to lightning. In addition, new technologies are emerging: Composite, More Electric and Alternative Fuel, bringing new safety requirements. For example, within the composite A/C environment, systems will be more exposed to lightning and induced arcing.SAFUEL will address the urgent need for European-led research in FS safety to develop the next generation of safer FS also offering the opportunity to reduce the current over-dependence on patented US technology.SAFUEL will develop:-the new FS design, meeting the severe safety constraints of Composite and More-Electric A/C and evolving flight conditions-a range of highly innovative prototypes, adequate testing and simulation tools to allow regulators to assess the safety of future FS as well as providing the necessary data to support authorities in rules and regulations for safe flight in icing conditions.The project will also significantly improve the compliancy of the FS with evolving flight conditions and emerging technologies, enabling perfect emergence of Composite A/C.By achieving these objectives, SAFUEL will reduce the rate of accidents/incidents related to FS from the cur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of home respiratory ventilators in the management of chronic respiratory failure' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Chronic respiratory failure (CRF) affects many of the citizens of Europe particularly the aged. The management of these cases is increasingly expensive. In the USA home respiratory ventilators (HRV) are commonly adopted as a technology contributing to less dependency and greater patient empowerment of those with CRF. In Europe this is a practice moderately well developed in a few countries but richweed variations in custom and practice. Against this background, as part of a Concerted Action, it is proposed to carry out a survey in sixteen European States and, on the basis of the information gleaned, if warranted, to move towards better standardisation of HRV practice. The long-term aim, in addition to reducing health care costs, will be to create an advisory authority with the capacity to monitor usage and if warranted arrange clinical trials. The project will be carried out with the active assistance of the European Respiratory Society
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhancement of natural water systems and treatment methods for safe and sustainable water supply in India' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Saph Pani addresses the improvement of natural water treatment systems such as river bank filtration (RBF), managed aquifer recharge (MAR) and wetlands in India building on a combination of local and international expertise. The project aims at enhancing water resources and water supply particularly in water stressed urban and peri-urban areas in different parts of the sub-continent. The objective is to strengthen the scientific understanding of the performance-determining processes occurring in the root, soil and aquifer zones of the relevant processes considering the removal and fate of important water quality parameters such as pathogenic microorganisms and respective indicators, organic substances and metals.Moreover the hydrologic characteristics (infiltration and storage capacity) and the eco-system function will be investigated along with the integral importance in the local or regional water resources management concept (e.g. by providing underground buffering of seasonal variations in supply and demand). The socio-economic value of the enhanced utilisation of the attenuation and storage capacity will be evaluated taking into account long-term sustainability issues and a comprehensive risk management.The project focuses on a set of case study areas in India covering various regional, climatic, and hydrogeological conditions as well as different treatment technologies. The site investigations will include hydrological and geochemical characterisation and, depending on the degree of site development, water quality monitoring or pre-feasibility studies for new treatment schemes. Besides the actual natural treatment component the investigation may encompass also appropriate pre- and post treatment steps to potabilise the water or avoid clogging of the sub-surface st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Cellular Basis of Multicellular Pattern Formation' to be submitted under Seventh Framework.

assistant: **Abstract**

The formation of plant organs (leaves, roots, flowers) depends on the activity of stem cells (SC), located in stem cell niches (meristems) together with adjoining organizer cells (OC) that prevent SC differentiation. Despite their importance, SC and OC have been poorly described at molecular and cellular level and mechanisms for their coordinated specification are only partially understood. We study the specification of the very first SC and OC for the root in the early Arabidopsis embryo where cell divisions are almost invariant and, in the absence of cell motility, highly predictable. Previously we have established a central role for the transcription factor MONOPTEROS (MP) in OC specification and we have recently found that MP also controls SC specification. Hence, MP offers a unique entry point into studying the genomic and cellular reprogramming that underlies coordinated SC and OC specification. Our recent identification of MP target genes has shown that its function in SC specification is cell-autonomous, while MP-dependent OC specification involves a mobile transcription factor.In recent years we have developed a set of resources to systematically study embryonic root meristem initiation, and are now in a unique position to answer the following questions in this ERC project:1. What transcriptional reprogramming underlies the first specification of SC and OC in the plant embryo?2. What cellular changes follow from transcriptional reprogramming and mediate elongation and  asymmetric division of SC and OC?3. What is the mechanism of directional protein transport that ensures spatiotemporal coordination between SC and OC?The project will provide genome-wide insight in the cellular reprogramming underlying the coordinated formation of a multicellular structure. Final