RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'THREATENED BIODIVERSITY IN MELIACEAE : URGENT NEED FOR A NEW TAXONOMIC FRAMEWORK FOR CONSERVATION' under Sixth Framework.

assistant: **Concept**

Milaca are a subtropical and tropical woody angiosperm family slightly penetrating into temperate zones, and occurring in a variety of habitats from rain forests and mangrove swamps to semi-deserts. They provide the paradox example of a group of plants with i) overwhelming economic and scientific-medicinal importance in both Europe and the USA, ii) one fourth of its species listed as being \threatened\" in the IUCN 2002 Red List,iii) being one of the plant key target taxa in campaigns of international conservation groups (e.g. Green peace anew, World Wide Fund for Nature) but ixia) still largely unclear taxonomies boundaries at species level throughout the family (e.g. Algeria, Cereal).The clarification of taxonomic delimitations of species is of profound importance if the full range of diversity, morphological and genetic, within Milaca target taxi is to be conserved for the future. The innovative aspect of this project is that morphological features currently broadly used as diagnostic characters in Milaca will be evaluated for their usefulness in delimiting genetic entities and therefore manageable units of biodiversity by use of phylogenetic trees derived from different nuclear and plastid DNA data. Another innovative aspect of the project will be that the data collected on genera Algeria and Cereal during the course of this study will be directly used to provide integrated information on status, trends, distribution and use of target taxi in order to support policy and action for the conservation and sustainable management of biological diversity in this family. This will be achieved by setting up IUCN Red Data assessments for taxa either not yet included in the IUCN Red Lists or included under an artificial taxonomie framework (\"complex\" species comprising sever
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Efa 2001' (1998-2002).

assistant: **Innovation**

This conference is organised every year by the European Finance Association. It is the main conference in Finance in Europe and it takes place in August in order to foster the participation of U.S. academics. The European Finance Association promotes the development of Finance in Europe. Its annual conference is a meeting point for European academics that benefit from each other different institutional background and thus are able to co-operate. The meeting covers issues on Portfolio Choice, Capital Budgeting, Corporate Governance, Market Microstructure, Option Pricing, and Mutual Funds Performance. Market Segmentation, Venture Capital, Emerging Markets, Bond Pricing and Financial Regulation, among others.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Concept Development of a System for Pods and Pod-Carriers to be used as Moving Infrastructures mainly for Rail, but as well for Road and Ropeways' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Two major issues of secondary lines rail transport are need to change the train for many destinations and to be bound to a timetable. Pods can be used to adopt rail transport better to the users demand by higher flexibility and efficiency as well as realising on-demand rail transport. The Project Pods4Rail aims to develop a concept for Pods and Pod-Carriers on Railway in order show the approach. Pod-carriers are serving as a moving infrastructure and the pods are loaded and locked on them for the transport. The main focus in Pods4Rail is the rail pod-carrier, which is presented in detail. Nevertheless, Pod-Carrier for Road and Ropeways are taken into consideration on a conceptual level to ensure the transferability of the concept. Related use cases and business cases are identified and analysed.


**Keywords:** Pod, Pod-Carrier, Multimodal-Mobility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Data Analysis in AMANDA and Monte Carlo simulation in IceCube' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Neutrino telescopes will open a new window to the Universe. Up to now, photons and cosmic rays have been the probes used to observe cosmic phenomena. However, there are important limitations for these messengers. Photons are absorbed by matter, the infrared radiation and the microwave radiation, so that they cannot reach us from very distant or very dense sources. Protons and nuclei are deflected by magnetic fields, so that directional information is lost. In this scenario, neutrinos arise like a promising new tool in the multi-messenger Astronomy because they are neutral, stable and only interact weakly. In order to detect cosmic neutrinos, very large detectors are needed. The major projects in this field are AMANDA, in the South Pole, and ANTARES and NE STOR in the Mediterranean Sea. AMANDA has provided important contributions to Astrophysics, such us the new limits to the neutrino flux. This collaboration has also shown that this kind of telescopes is feasible and has encouraged the planning of the next step: IceCube, which will be a larger (one cubic kilometre) and improved version of AMANDA. Several European institutes (from Germany, Sweden, Belgium and the U.K.) are active members of these Euro-American collaborations. ANTARES and NESTOR are European projects. Both experiments will deploy a neutrino telescope in the Mediterranean Sea to show the feasibility of detecting neutrinos undersea. As in the case of AMANDA, it is planned to go further in this way, with a cubic kilometre telescope, the KM3Net project. The work of the applicant will be twofold. He will analyse the data of AMANDA and will perform Monte Carlo simulations to establish the performances of IceCube. In this work, the experience of the researcher in ANTARES for four years will be extremely useful.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Performance based seismic design of structures' in the context of a Sixth Framework call.

assistant: **Objectives**

Structural damage and life losses due to recent earthquakes show that design procedures in current codes throughout the world need to be improved to adequately consider the non-linear behaviour of the structures and control their performance when subjected to demands which may occur during their design life. This proposal addresses the problem of defining a consistent performance based seismic design methodology and developing design methods which guarantee that, under design actions, the structures perform as expected.The project involves: Definition and validation of seismic design and performance levels applicable to structures in Mexico and the EU using field and experimental damage data and probability concepts. Validation of a recently proposed design method based on concepts of structural performance evaluation, an approximate non-linear procedure for the determination of seismic performance, and advanced concepts on dynamics and probability. Improvement and modification of this method to consider the design of asymmetric buildings and irregular bridges subjected to bidirectional earthquake action. Development of uniform hazard design spectra using a probabilistic formulation based on rates of exceedence of the performance indices. The procedure to obtain these spectra will consider all known uncertainties on the parameters of the seismic sources, their annual rate of exceedence of magnitudes and the characteristics of the structures.To calculate the probability that a structure exceeds a given performance level, the Monte Carlo method will be used with the responses of equivalent single degree of freedom systems subjected to a large number of records of different magnitudes simulated for particular earthquake generation processes and methods such as the empirica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cutting-edge insoles with advanced characteristics for medical and sports applications', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Gait dynamics’ monitoring and Energy Expenditure (EE) calculation is of high importance for patients with chronic diseases affecting normal walking, for individuals after injuries & surgery, as well as for older adults, in order to early detect and correct gait problems or accelerate rehabilitation. The need extends to the multibillion industry of professional athletes for a) load management (injury prevention, performance optimisation), b) accelerated recovery from a lower limb injury, c) running efficiency optimization and precise body control.Due to the significant drawbacks of market available systems (high price, difficult to use software, necessity to operate under expert supervision, intrusiveness), gait analysis is used less often than would actually be required. For patients & clinics, this has an impact on rehabilitation time & cost, as well as on the timely detection of certain medical conditions. For athletes, this has an impact on costs related to delayed rehabilitation, but also on increased cost for injuries that could have been avoided. insofeet is a completely non-intrusive insole for measuring accurately key gait dynamics’ parameters and EE. The insofeet insoles are capable of fitting in different shoe types. The insofeet insole integrates highly accurate miniature force sensors in a customisable design, adaptable to the application. Sensor measurements are collected in real-time, processed through validated algorithms and presented through a friendly interface. What differentiates insofeet from the competition is its unparalleled accuracy, comparable to hi-end professional solutions at a price 15 times lower. An EU/WO patent application  was submitted by CyRIC.Our goal is to bring the insofeet solution to market, after preparing an elaborate business
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unlocking a T cell-mediated Immune response in therapy-challenged Tumors' to be submitted under Horizon Europe.

assistant: **Abstract**

Immuno- and targeted therapies have revolutionized the treatment of cancer patients, and more innovative therapeutics, such as KRAS inhibitors (KRASi), are entering the clinic. However, their use as monotherapies fails to achieve durable tumor control in most patients, and the development of combination therapies remains challenging without an understanding of the complex and dynamic biology that unfolds upon therapeutic challenge in the tumor microenvironment (TME). Most of our knowledge on combination therapies is based on primary, treatment-naïve tumors, but how signaling networks of cancer cells and their interactions with immune cells evolve under therapeutic challenge over time is poorly understood, and strategies to overcome immune-evasive TMEs are lacking. Here, we build on our expertise in modeling the dynamic changes of cancer cells in all phases of therapy to move towardsstrategic, mechanism-based combination therapies. Our vision is to Unlock a T cell-mediated Immune response in therapy-challenged Tumors, “UnlockIT”, to achieve durable therapy responses in cancer patients. (1) We will use our improved molecular time machine, CaTCHseq, together with novel KRASi and unique KRAS-driven tumor models to understand tumor-TME co-evolution under KRASi and related mechanisms of drug-resistance. (2) We will characterize mediators of antigen processing and presentation in treatment naïve, therapy-challenged and immune evasive cancer cell states by using state-of-the-art genome-wide CRISPR/Cas9 screens in combination with innovative phenotypic readouts. This approach offers a sought-after opportunity to uncover mechanisms that make cancer cells “visible” to immunity. (3) Finally, we aim to overcome immune-evasive TMEs by understanding and targeting antigen-presenting ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Immune Mechanisms of Necrotic DNA Phagocytosis by Neutrophils: A Role for Integrins', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cell death is inherently connected to the existence of multicellular organisms. Our body loses billions of cells a day due to thermal, mechanical or chemical damage in a cell death process with loss of plasma membrane integrity and pro-inflammatory properties known as necrosis. Organisms face necrosis frequently, thus, there must be specific pathways to remove the large amount of cellular debris left behind. In this way, it is no surprise that improper removal of cellular debris, such as DNA, is associated to inflammatory diseases as lupus erythematosus, acute liver injury, atherosclerosis and severe trauma. Removal of necrotic debris is thought to be mediated by phagocytes, although reports showing it are scarce. Neutrophils, a subset of phagocytes, are good candidates for debris removal since they are abundant and quickly recruited to necrotic sites. The means used by neutrophils to identify, internalize and degrade necrotic DNA are currently unknown, thus, the main objective of my project is to understand how neutrophils phagocytose and eliminate necrotic DNA debris. Neutrophils express the DNA-sensing receptor TLR9, which is not a phagocytic receptor. However, they also express very high levels of beta2 integrins such as CD11b/CD18, which act as adhesion molecule and as complement receptor (CR3). The release of necrotic DNA promotes complement activation in vivo through several pathways, therefore, my hypothesis is that neutrophils use beta2 integrins to bind and phagocytose complement-coated necrotic DNA. To assess the role of beta2 integrins, TLR9 and complement in phagocytosis of necrotic DNA by neutrophils, I will combine a novel in vitro method (DNA deposit in coverslip) with an in vivo approach (confocal intravital microscopy). I will also develop novel peptid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strategies for the eradication of bovine tuberculosis' (TB-STEP).

assistant: **Concept**

Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis complex. This infection affects domestic and wild animals and represents a major concern worldwide because of its high economic impact due to mortalities, condemnations, decreases in productions, and its zoonotic potential.   Eradication programmes based on a test-and-slaughter policy in the EU have proved successful in some countries, however, have been unable to eradicate the infection in others despite the use of vast economical resources. A relevant problem is the existence of infected wildlife; the best known examples are the European badger (Meles meles) in UK and the Republic of Ireland, and the wild boar (Sus scrofa) in Spain. Besides this fact, there is only a limited knowledge about other potential underlying causes, such as (1) the real contribution of cattle-to-cattle transmission at the same area (neighbouring farms and communal pastures) or after movement of animals; (2) the role played in the epidemiology by other domestic animals, or (3) the effect of interferences in the diagnosis tests. The weight of these causes may also differ depending on the farming system and ecological factors.  Likely there is not a single solution as likely there is not a single cause. To approach the eradication of this infection, this TB-STEP project plans a multifaceted battlefront. The consortium is made up of 12 partners from eight countries which will research on eight work-packages devoted to improved tools and to develop strategies for the eradication of bovine tuberculosis in areas where the disease is present in both domestic and wildlife populations. It will include: 1) vaccination of bovine animals and wildlife, (2) control of populations to reach numbers compatible with animal welfare an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The polyA machinery: Elucidating the molecular mechanisms of mRNA polyadenylation, deadenylation and RNA recognition' (POLYAMACHINES) under Horizon 2020.

assistant: **Objectives**

Gene expression is tightly regulated to allow rapid responses to cellular stimuli. In eukaryotes, the 3´ polyA tail of mRNAs plays key roles in post-transcriptional control. The Cleavage and Polyadenylation Factor (CPF), Ccr4–Not and Pan2–Pan3 multiprotein complexes add or remove polyA tails to regulate mRNA stability and efficiency of translation. They control expression of genes in the inflammatory response, miRNA-targeted gene silencing and expression of maternal mRNAs in oocyte development. These processes are deregulated in disease, including cancer and neurological disorders.Although the proteins that add and remove polyA tails are known, their mechanisms are poorly understood. My lab recently established methods to reconstitute the polyA machinery. This led to new insights into the link between transcription and polyadenylation, new understanding of the molecular mechanisms of deadenylation, and details of RNA recruitment.In this proposal, my objective is to understand the molecular basis for polyadenylation and deadenylation of specific mRNAs. This is now possible because of our novel methodological and biological advances. We will determine high-resolution structures of the polyA machinery using electron cryo-microscopy (cryo-EM), reconstitute their biochemical activities in vitro and study their in vivo functional roles. We use this integrated approach to study intact multiprotein complexes, not individual subunits or domains. This involves considerable technical challenges and an investment in developing high quality purifications and new structural methods. I will determine how the four enzymatic activities of CPF are coupled, the mechanisms by which Ccr4–Not targets specific RNAs, and the molecular basis for RNA recognition by Pan2–Pan3. Together, this will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Using the smart matrix approach to enhance TADF-OLED efficiency and lifetime' (TADFlife).

assistant: **Innovation**

The European Training Network TADFlife will train a cohort of young PhD scientists within a multidisciplinary research program conceived from a simple industrial need, high performance blue OLEDs which also have long lifetime. This is not an easy problem to solve, as although OLEDs are now ubiquitous in phone and TV displays, the blue pixels still operate far below the performance and efficiency of the red and green to achieve acceptable lifetime. TADFlife will follow a new approach to solve this problem using the latest generation of OLED materials, thermally activated delayed fluorescent (TADF) emitters. Through a device simulation development program, which incorporates a high degree of basic photophysics input, predictive models of TADFOLED performance and lifetime will be built and used to design new TADF emitters and hosts which overcome the degradation pathways identified from the model predictions. These new materials will then be synthesised. By introducing the concept of the smart matrix, the complex guest host interactions of TADF materials will be included and used to optimise emitter orientation to maximise light out-coupling from devices. Quantum chemistry will use the photophysics results to direct new materials design in tandem with the model predictions. Taking this dual approach, we believe will lead to solutions so far unobtainable for OLEDs. This highly interlinked program gives a fantastic opportunity for the brightest young chemists, spectroscopists, theoreticians and device physicists to work together, learn complimentary skills that will be in high demand from European OLED industries.  Leading experts will give courses on core scientific skills along with soft skills and international secondments will be offered, all to properly prepare them for