RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pluralisme des fondements des positions de bioethique et fonctionnement des institutions europeennes' under Fourth Framework.

assistant: **Concept**

The objective is to provide the results of an analysis of the philosophical pluralism basing the various bioethical positions with regard to plant, animal and microbial biotechnology (non medical applications) in the EU, and the way in which such pluralism is taken into account by the European institutions, based on a case study; the directive on the protection of biotechnological inventions. The project is pluralistic, transdisciplinarian and pluri-cultural in nature. This is why a concerted action has been chosen for its implementation. The main participants are experts in fields such as epistemology, philosophy, law, political sciences, biology ... They will be asked to produce a paper on the subject, based on their particular expertise and experience, and on their previous work. These papers will constitute the basis of a document which will then be offred for discussion in a workshop, together with representatives of different opinion groups in the EU (in a pluralistic manner). A summary of the discussions and recommendations to the Commission will then be produced by the coordinator. It is observed that the debate between pros and contras on the applications of biotechnology is based on a simplistic dichotomy opposing, on one side, scientists and industrialists, all in favour of technological and economic development, and, on the other side, opponents who, explicitly or not, base their opinion on a particular philosophical understanding of nature, the economy or their vision of the decision-making process within the European inst itutions. The treaties do not take any stance on these philosophical issues, hence the institutions representatives do not dispose of a clear mandate in the field. Should they take one or the other, dominant or not, philosophical position
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cell of origin/Leukemia Initiating Cell in infant Pro-B MLL-AF4+ ALL' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Infant pro-B acute lymphoblastic leukemia (ALL) carrying the fusion oncogene MLL-AF4 is associated with very brief latency and dismal prognosis. Recent studies have revealed an in utero origin of MLL-AF4 but the nature of the target cell for transformation in the embryo/fetus is unknown. Because of the mixed phenotype and the presence of MLL-AF4 in both lymphoid and myeloid lineages, hematopoietic stem/progenitor cells (HSPCs) are likely targets for transformation. The absence of bona fide disease models reflects our very poor understanding of the etiology, pathogenesis, cell of origin and secondary oncogenic events of this leukemia. Here it is proposed to create a murine model for infant MLL-AF4+ pro-B ALL using lentiviral transduction of MLL-AF4 or AF4-MLL in HSPCs at different developmental stages: aorta-gonad-mesonephros (AGM), fetal liver (FL) and neonatal BM. These HSCs can be harvested from a novel BAC transgenic reporter mouse model that based on Vwf-EGFP expression divides multipotent adult HSCs, homogeneous by thus far characterized phenotypes, into two prospectively isolatable subsets: vWF+ HSCs (with platelet/myeloid-biased output) and vWF− HSCs (with lymphoid-biased output). Here, primary lymphoid-biased vWF− HSCs will be used to stably express the oncoproteins and then injected into lethally irradiated hosts. For the first time, we will exploit a model that deciphers HSC heterogeneity to study the transformation capacity of leukemogenic oncoproteins in a specific HSC subset.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Developing a marketable and ecologically sound plant growing medium from waste products found in lakes and rivers'.

assistant: **Concept**

This proposal aims to develop a new horticultural product, which would be commercially attractive to a growing and diverse market. It will use silt, mixed with other materials to develop a form of compost whose attraction is that it is based on waste products and does not cause environmental damage. Using the example of Cardiff, where a city centre lake is being unfilled by silt, causing a problem which is expensive to premeditate, we aim to- Develop silt traps to remove the silt before it becomes a problem- Determine cost effective ways of transporting the material- Assess the additives to be included with the silt- Review packaging options- Determine marketing requirements, market trends and competitor products- Assess potential costs, prices, outgoings and income. The research will demonstrate that the product can be developed successfully and sold commercially to farmers, local authorities and the domestic gardening market. The SME co-ordinator is based in Cardiff, and has teamed up with a company from Finland who are currently expanding their product range to include horticultural products from sustainable sources.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ethics of enhancement technology' (ETHENTECH).

assistant: **Innovation**

The main objective of this ETHENTECH project is to take substantially further forward both the ethical evaluation and public discussion of two important emerging fields of micro- and nanobiotechnology which pose very significant ethical and societal issues of public concern: neurological implants and the potential for human functional enhancement. Neural implants are a major new class of medical devices, which create an interface between nerve tissues and nano- or micro-scale probes. The aim is to enable a patient’s nervous system to communicate with new devices that replace or supplement a malfunctioning organ, for example to restore hearing or eyesight or to treat degenerative diseases like Parkinson’s.   Human functional enhancement technology refers to a wide range of converging technologies which have the potential to enable significant modification of the systems of the human body, beyond what might be seen as medical purposes. The subjects of the ETHENTECH project address some of the most far-reaching fields among new and emerging technologies today - in terms of their potential social impact and the challenges these will pose to ethical issues and values of European citizens and societies. The project’s two fields of implant and human enhancement technologies both lack ethical frameworks and European and international guidelines. This absence reflects the emerging and complex nature of both areas. They also represent cases where issues of dual use are a significant and further complicating factor. While several EC and other projects have given useful overviews of the ethical terrain, it is clear that there is now a pressing need to engage in more depth with particular issues in order to focus ethical frameworks and guidelines around particular issues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Sorting out Polarized Transport in Neurons: Motor Protein Selectivity and Cooperativity'.

assistant: **Innovation**

Neurons are the building blocks of the brain. The ability of neurons to receive, process and transmit information depends on their polarized organization into axons and dendrites. To build such a highly polarized cell, cellular components synthesized in the cell body are differentially transported to either axons or dendrites. Polarized transport is driven by three families of cytoskeletal motor proteins, which can walk in different directions over the actin or microtubule cytoskeleton. Many subfamilies of motor proteins exist, but how each of these motor proteins contributes to selective cargo delivery is unknown.I have recently developed an approach to probe specific motor activity inside cells, which revealed that many microtubule-based motors selectively target axons. However, the molecular mechanisms behind this remarkable selectivity are unknown. In addition, it is well-established that most cargos are transported by a combination of different motors, but how the activity of different types of motors on the same cargo is integrated has remained unclear.The aim of this proposal is to understand how motor proteins navigate the neuronal cytoskeleton. We will take a multidisciplinary approach and combine neurobiology, molecular engineering, advanced microscopy, and mathematical modelling to study the origin of motor selectivity as well as the collective activity of dissimilar motor teams. We will employ and expand our unique methodology to: 1) Study how the spatial organization and post-translational modifications of the microtubule cytoskeleton facilitate selective transport. 2) Perform well-controlled intracellular multi-motor assays to understand the functional interplay between different types of motors.Successful achievement of these objectives will uncover key m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Analysis of its role as a transcriptional activator and/or repressor through gene targeting in the mouse' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content  C/EBPD is a factor believed to regulate transcription of IL-6 responsive genes and of the IL-6 gene itself and the differentiation of myeloid and Iymphoid lineages Its mRNA generates two proteins with opposite functions: the full-length trans-activator and a truncated form, LIP, thought to act as a repressor A null mutation of the gene, inactivating both C/EBPb forms causes both defective and increased transcription of different target genes. To clarify the physiological role of C/EBPB, I propose to analyse liver and macrophagic cell lines derived from C/EBPB-deficient mice and to specifically inactivate either the full-length or the truncated form of C/EBPB by gene targeting, in order to investigate the real contribution of the two forms to the functions of the factor. Training content (objective, benefit and expected impact)  By performing gene targeting in the mouse, I will gain new experience in the study of gene expression in a complex in vivo system and learn the techniques of genetic manipulation of the mouse genome. I will also acquire more experience with derivation of stable cell lines, which will allow me a more sophisticated analysis than what is possibie in the whole organism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Voluntary certification scheme for waste treatment'.

assistant: **Objectives**

The CEWASTE project contributes to an improved recovery of valuable and critical raw materials (CRMs) from key types of waste through traceable and sustainable treatment processes in the entire supply chain of secondary raw materials. As such, CEWASTE will address the specific challenge to secure the sustainable access to CRMs for the EU economy and objectives set by the EU action plan for the Circular Economy, the issue of illegal trade of wastes within the EU and to non-EU countries and the need to support the development of environmentally and socially sound recycling systems globally. Specifically, the project will develop, validate and launch a voluntary certification scheme for collection, transport and treatment facilities of key types of waste containing significant amounts of valuable and critical raw materials. To ensure a comprehensive approach and a robust result, the project will be developed along the following six specific objectives: Objective 1 - Understand existing recovery practice, standards and verification schemes; Objective 2 - Develop sustainability and traceability requirements; Objective 3 - Develop an assurance system and related verification procedures; Objective 4 - Validate the new voluntary scheme; Objective 5 - Ensure long term sustainability of the scheme; Objective 6 - Ensure a transparent stakeholder process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Smart Energy Solutions for Africa' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

SESA will facilitate a structured co-development process, which starts with the co-development of energy access innovations that have a high potential for take-up and are tested, validated and later replicated. Each technology will be demonstrated in the living lab, and a corresponding information and training package is created. Each of the living lab team will consist of technology experts, local implementation partners (members of the consortium) along with local authorities (associated partners) and innovators (recruited through the seed-funding call), guided by business development, finance and policy experts. Demonstration actions will aim to test innovative technologies and services in different contexts that have a high level of replicability and a high potential for long-term sustainability.  The project aims to achieve a high level of replicability of actions. As part of an effort to go beyond the state of the art and maximise the project?s impact, the project will co-develop innovations with local partners and cooperate closely with sister projects to exploit synergies. Solutions that will be tested in this project have been selected on their basis of their replication potential. Demonstration concepts aim to integrate several solutions to provide essential energy services to rural and urban communities and create easily replicable business opportunities for local entrepreneurs. The co-developed demonstration actions will be initially tested in the Kenya living lab and based on the initial learnings, various aspects of the tested innovations will be validated in living labs in different socio-economic operating environments (Ghana, South Africa, Malawi and Morocco). The learning from the validation living labs will strengthen the applicability and replicabili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Generation and detection of many-particle entanglement in quantum optical systems'.

assistant: **Objectives**

During the last decade, quantum entanglement has been intensively studied within quantum information science and has also appeared as a natural goal of recent quantum experiments. Because of that the theoretical background of detecting entanglement has been rapidly developing. However, most of this development concentrated on bipartite or few-party entanglement, while today's experiments typically involve many particles. Thus, as one of the most interesting part of quantum optics and quantum information, I chose to study multi-partite entanglement theory, with a stress on creation and generation of many-particle entanglement. There are two main system types in today's experiments. In some systems all particles are individually accessible, such as trapped ions or photons. In such systems entanglement detection is still a challenge as the number of local measurements is limited. I propose to study efficient methods for detecting entanglement in such systems. In other physical systems, such as cold ensembles of a million atoms, particles are not accessible individually and only collective measurements are possible. To obtain useful information about the quantum state is a challenge. I propose to study entanglement creation and detection also in such systems. The latter topic is naturally connected to the  efficient modeling of large quantum systems, since exact modeling is not possible for such system sizes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Circular lignin materials from well-defined functional building blocks' under Horizon Europe.

assistant: **Concept**

Lignin is a natures wonder material that allows trees to grow vertically and have strong and biochemically resistant structures. However, the majority of lignin is burned in the forest industry. The objective is to make a paradigm shift in the use of lignin by developing circular lignin materials with functionalities arising from well-defined nanostructures. This project faces two outstanding challenges. The first relates to overcoming the instability of lignin nanoparticles in organic solvents and under alkaline conditions, which currently restricts synthesis of advanced lignin materials. The second is to develop lignin nanoparticles and lignin fibres structurally incorporating inorganic and metal nanoparticles. By overcoming these obstacles, we will have functional lignin building blocks for circular vitrimer adhesives, electrochemical catalysts, magnetically responsive nanocomposite gels, and colloidal crystals. Synthesis and assembly of these materials requires considerable contributions to method development that will open wholly new frontiers for sustainable lignin materials. Far-reaching implications beyond materials science include excellent opportunities for interdisciplinary studies across environmental sciences, chemical and process engineering, and life sciences.


**Keywords:** Lignin,  hybrid,  nanocomposites,  nanoparticles,  nanofibres,  colloidal crystals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'microRNAs in vascular homeostasis'.

assistant: **Objectives**

Despite improved therapy, cardiovascular diseases remain the most prevalent diseases in the European Union and the incidence is rising due to increased obesity and ageing. The fine-tuned regulation of vascular functions is essential not only for preventing atherosclerotic diseases, but also after tissue injury, where the coordinated growth and maturation of new blood vessels provides oxygen and nutrient supply. On the other hand, excessive vessel growth or the generation of immature, leaky vessels contributes to pathological angiogenesis. Thus, the regulation of the complex processes governing vessel growth and maturation has broad impacts for several diseases ranging from tumor angiogenesis, diabetic retinopathy, to ischemic cardiovascular diseases. MicroRNAs (miRs) are small noncoding RNAs, which play a crucial role in embryonic development and tissue homeostasis. However, only limited information is available regarding the role of miRs in the vasculature. MiRs regulate gene expression by binding to the target mRNA leading either to degradation or to translational repression. Because miRs control patterns of target genes, miRs represent an attractive and promising therapeutic target to interfere with complex processes such as neovascularization and repair of ischemic tissues.  Therefore, the present application aims to identify miRs in the vasculature, which regulate vessel growth and vessel remodelling and may, thus, serve as therapeutic targets in ischemic diseases. Since ageing critically impairs endothelial function, neovascularization and vascular repair, we will specifically identify miRs, which are dysregulated during ageing in endothelial cells and pro-angiogenic progenitor cells, in order to develop novel strategies to rescue age-induced impairment of neovasc