RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Turbine Aero-Thermal External Flows 2 (TATEF2)' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The High Pressure Turbine is a particularly sensitive engine component. The blade life duration, the efficiency and the fuel consumption are critical issues. The trends are to increase the turbine inlet temperature for unimproved cycle and the stage load to reduce the engine weight. The new generation of low Knox emission combustion chambers impose aggressive inlet conditions with hot spots and swirl. The film cooling used to protect blades from hot gas must be optimised not to be detrimental to the fuel consumption. The sources of aerodynamic losses need to be quantified and graded in unsteady flows. Not to penalise the performance, the turbine design must combined opposite constraints. So, heat transfer and aerodynamic losses in unsteady turbine external flows must be predicted more precisely. The physical understanding of such complex phenomena is mandatory for improved design practices. Numerous small-scale technological effects and advanced modelling must be considered for design tools to increase their prediction capability. The project aims at building experimental databases needed for design tools validation. Detailed 3D unsteady measurements in engine representative configurations will be performed. The measurement of turbine efficiencys a European first in full scale short duration rigs and will permit to quantify the effects of inlet swirl, enhanced hot spots, rotor platform cooling, high pressure stage with strong shock waves and a new architecture of low-pressure vane which combines structural struts. More fundamental research will be carried out for detailed film cooling efficiency in transonic flows, with whole entrance effect and in multi-row configurations. The industrial partners will validate and assess their design tools against experimental results
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Patient specific biomimetic materials for bone regeneration' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Over 2 million bone grafting procedures are performed annually worldwide nearly half of them in the EU, being the 2nd most transplanted tissue after blood. Bone defects pose a great clinical and socio-economic problem, only worsening with the ageing population. Even if bone harvested from the patient, bone banks or animals are common standard, they present serious disadvantages (limited availability, immune responses, disease transmission, ethical issues). Various synthetic bone grafts have been developed to minimize complications, yet with low success and failing to accelerate natural bone growth.Bone3Dmatch revolutionizes the market of bone grafting (3.2bn€ globally) with a new generation of synthetic biomaterials. Two main disruptions are brought forward: 1) Biomimicry: The biomaterial, its aqueous composition and low-temperature processing is capable of mimicking the bone creation conditions. Thus, it is recognised as natural bone by bone cells, accelerating the bone regeneration and the patient’s recovery. 2) Patient customisation: Through advanced 3D printing technologies, it manufactures patient-specific scaffolds in less than 72h. This enables the treatment of complex bone defects, changing the current paradigm to a patient specific treatment. The company behind Bone3Dmatch is MIMETIS, a young SME built on the back of 25 years of research and business acumen in biomaterials for bone regeneration. Currently, MIMETIS offers biomimetic granules for the dental market. With an investment of 1.1M€, Bone3Dmatch will accelerate the market introduction of the 4th generation biomaterial in a completely new form (3D-printed scaffolds). Targeting orthopaedics and cranio-maxillofacial, we expect to reach the market in 2020 achieving 4,9M€ in revenues in only 3 years. Moreove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reversible Gray Debugging of Concurrent Systems' (ReGraDe-CS) under Horizon Europe.

assistant: **Objectives**

The project tackles gray debugging of concurrent systems. Gray debugging means debugging systems where only part of the source code is accessible (e.g., the system invokes external services such as Google Maps). Debugging concurrent systems (from multiprocessors to Cloud) is notoriously hard. Reversible Causal-Consistent Debugging and Replay (RCCDR) is an innovative approach to this problem, allowing one to log a faulty execution in production environment and replay it in the debugger. There it can be explored backwards and forwards following causality links from the visible misbehavior to the bug causing it. This approach has been implemented in CauDEr, a debugger for the Erlang language.Currently, RCCDR requires access to the whole source code of the target program.  To enable gray RCCDR we need to answer the following questions:How can we define RCCDR, and, more generally, reversibility in concurrent systems, in a compositional way, to be able to apply it to systems which are only partially accessible? Are we able to correctly explore backwards and forwards the accessible part? If not, which approximation in the exploration is caused by the missing information about the inaccessible part? Till now RCCDR has only been explored in the concrete setting of Erlang, and gray RCCDR has never been studied.  We plan to study gray RCCDR at two levels:1) the abstract level of event structures. Abstraction ensures simpler proofs and generality of the results, making them applicable to many languages;2) the concrete level of Erlang semantics, ensuring applicability in a setting of interest, and allowing to implement it by extending CauDEr and integrating it in the Erlang Solutions environment. As an outcome we will provide the theory to apply the powerful RCCDR approach to concur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Enhancing the performance of 3D-printed organic thermoelectrics by electric field-assisted molecular alignment'.

assistant: **Concept**

Thermoelectrics (TEs) are important because they can convert heat directly into electrical energy and enable efficient heating/cooling. However, their popularization has been hindered by 1) their low efficiency (especially at room temperature), 2) the use of rare/toxic materials, and 3) the difficulty to process those materials. In 3DALIGN, I target a 3-in-1 solution to these challenges by using for the first time electric-field-assisted molecular alignment of 3D-printed TE polymers. High electrical/low thermal conductivity is required for efficient TEs, but both conductivities go hand in hand in traditional inorganic TE materials. This paradigm can shift for polymers, which possess complicated molecular structure. Despite their relatively low electrical conductivity, conducting polymers are appealing for TEs due to their much lower thermal conductivity than inorganic TE materials. Existing studies of organic TEs have focused on finding new materials, but no attention has been paid to molecular ordering, a known strategy to improve performance in organic transistors. I have recently developed a versatile method to induce molecular alignment in solution-processed polymers by using externally applied electric fields. In 3DALIGN, I propose to use this new method to boost the electrical conductivity of polymer TEs while inducing minimal alteration in their thermal conductivity. The high-risk of this goal is mitigated by other advantages of using polymer TEs: polymers are less toxic and more abundant than inorganic TE materials; and they are easy to 3D print, enabling a simple fabrication route for large-area through-plane TE structures that will lead to novel applications. In conclusion, this project will shed light in the relationship between molecular ordering and transpo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'International Forum for Aviation Research Support Action', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Climate change is one global topic which is currently world-wide discussed by politicians and scientists. The Forth Assessment Report of the International Panel on Climate Change (IPCC) has stirred an intensive public debate on future aeronautical research challenges and policies. This report identifies aviation to contribute 2–3 percent of today’s total global anthropogenic CO2 emissions. This prompted the International Air Transport Association (IATA) to set the long term challenge of Zero Emission Aviation by 2050 and emphasised the importance of addressing these challenges on a global level. The answers and solutions to these demands are expected to be given by research. Except networks on continent level (e.g. EREA in Europe), the worldwide aerospace research organisations are currently not coordinated and do not have a representative who can react to the political questions and demands. The German Aerospace Center (DLR) took this need as opportunity to organise 2008 and 2010 a Summit and invited key leaders of international aeronautical research to address the question of the Air Transport of the Future in the context of climate change. In 2008, the participants discussed possibilities and strategies. In 2010 the participants founded the International Forum for Aviation Research (IFAR) which aims to find potential solutions for ecologically and economically efficient flights. IFAR will develop a Road Map addressing the most important questions regarding the aviation challenges; the global air transport system's efficiency, atmospheric impact but also other topics as safety, noise and new technologies. Thus the strategic goal of IFAR is to generate and to collaborate in the aviation research challenges and technology avenues worldwide. The proposed EU project IFARs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional implications of inter- vs. intraspecific trait diversity in European forests' (DIVERFOR), addressing dissemination and exploitation.

assistant: **Impact**

The study of the influence of biodiversity on ecosystem processes is an expanding research as a result of the growing concern that loss of biodiversity may impair ecosystem functioning. An important generalization assumes a positive relationship among the community diversity and its stability in response to environmental disturbances, thus a key subject under the global change scenario. Recently, the functional approach to diversity (i. e. the functional expression of diversity) has emerged providing a closer explanation to the actual mechanisms of biodiversity-ecosystem functioning relationships than the traditional expression of diversity. An important number of studies have thrown some light on trait meanings and assessments; and several works have addressed the development of indices and mathematical frameworks to estimate functional diversity. However, these methods have often neglected the intraspecific trait variability (phenotypic differences within a species), commonly comparing mean trait values per species. The aim of this proposal is to understand the extent and implications of the inter and intraspecific trait variability on forest functioning, in particular on the recruitment process and the productivity across a climatic gradient in European forests. The rationale for including within-species variability is that European forests are relatively species-poor, so the phenotypic variation in functional traits within species is likely to be more relevant for a community and ecosystem processes that at species level. In this context, to disentangle the relationships between functional diversity and forest functions, we will characterise the inter- and intraspecific variability of functional traits in tree species, analysing the extent of each component in diffe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Multimodal labelling probes for correlative nanoscale mass spectroscopy imaging, optical and electron microscopies'.

assistant: **Objectives**

The applications of the integrative imaging approach relying on a unique combination of correlative microscopy methods such as secondary ion mass spectroscopy (SIMS) and optical microscopies such as stimulated emission depletion (STED) and electron microscopy (EM) are powered by the development of novel labelling probes for imaging, which play a pivotal role in their progress. There is currently a lack of new probes that can provide a high signal-to-noise ratio and low background in correlative microscopy during the acquisition process by photon counter and mass detector. Therefore, many scientists still cannot apply these advanced microscopy methods to their samples. The unique probe features will result in better contrast and spatio-temporal resolution of the obtained images. Now organic chemists can use the developed organometallic reactions to obtain the target fluorophores for probe construction. This research initiative relying on the tailor-made design and elaborated synthetic strategies will allow obtaining a new class of unique imaging probes with optimized optical properties. The new labelling probes, together with the optimized protocols for sample preparation and image analysis, will help get better image quality, which altogether will provide multi-dimensional information about the studied samples. I will develop new labelling tools for correlative multimodal imaging. Structure-property optimization of such labelling tools requires a tailor-made design of the fluorescent dye, which will not compromise intrinsic photophysical properties responsible for its fluorescence, such as ""photon"" or quantum yield. I will employ three different biochemical approaches to obtain the labelling probes. The probe design comprising functionalized nanobodies, gold nanoparti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Advanced Modeling CapabiLities For UHBR Low Noise Fan Technology'.

assistant: **Concept**

The design of innovative low fan noise technologies for next generation UHBR engines is highly conditioned by the accuracy of aeroacoustic modelisations and related design tools. To further guide UHBR Low fan noise design and noise reduction technologies, the AMICAL project is focused on applying advanced high-fidelity numerical tools, based on Lattice Boltzmann and high order Navier-Stokes methods, to realistic fan/OGV  configurations, including installation effects and wind tunnel environments. In addition several noise reduction mechanisms will also be simulated with high-fidelity methods. As a by-product , the high-fidelity simulations will be exploited to validate and improve lower fidelity noise prediction methods, in support of the engineering needs for fast and reliable design tools.In order to exploit combined acoustic numerical and experimental databases, new post-processing methodologies will also be developed to  identify 2030+UHBR fan noise sources and improve the physical understanding of noise generation mechanisms. The AMICAL consortium is formed by NUMECA, a Belgian SME active in flow simulations (also coordinating the project), a Dutch expert in noise identification and post-processing (PSA3) and CERFACS a major French research center. All three partners have an extensive experience in EU and Cleansky projects.


**Keywords:** High-fidelity simulations,  UHBR,  Tonal and broadband noise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Risk Assessment of Exposure to Particles' (2002-2006).

assistant: **Innovation**

Some NEST have the potential to generate particulates which can enter the body via inhalation, ingestion or dermal absorption. As new materials are generated from sources as diverse as novel combustion systems, nanotechnology or pharmaceutical drug deliv ery in the life sciences there is potential for human exposure. Inhalation exposure to dusts leads to pulmonary diseases and particle toxicity increases with decreasing particle size. Information is needed regarding the possible risks from exposure to th ese particles including: the routes of exposure and subsequent disposition; their potential toxicity; appropriate toxicological testing procedures; and susceptible subpopulations. This study will acquire a bank of five particles potentially generated by N EST (NESTP) and will assess the health risk from exposure to these materials through air or the food supply with a work programme, integrating in vitro experiments, animal models of healthy/susceptible individuals and exposure/risk assessment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The function of B cells in myocardial infarction-accelerated atherosclerosis'.

assistant: **Objectives**

Survivors of acute myocardial infarction (MI) are at a particularly high risk for accelerated atherosclerosis and recurrent atherothromobosis. Nevertheless, mechanistic preclinical studies in atherosclerosis research world-wide are typically conducted in unchallenged (without MI) atherosclerosis-prone mice and thus do not address the specific pathophysiology of post-MI atherosclerotic cardiovascular disease. We conducted a single-cell RNA sequencing coupled to B cell receptor (BCR) sequencing analysis of sorted CD45+ splenocytes from atherosclerosis-prone mice that were fed an atherogenic diet for eight weeks in total and were subjected four weeks after the initiation of the atherogenic diet feeding either to sham microsurgery or to permanent ligation of the left anterior descending coronary artery to induce MI. We found that splenic mature B lymphocytes from atherosclerotic mice that suffered an MI display altered glucocorticoid-induced responses and a more diversified BCR repertoire, which contains twelve unique clonotypes (named B-MIracle clones) that are not present in atherosclerotic mice without MI. Here, I aim a) to investigate the effect of glucocorticoid-induced signaling in B cells in post-MI atherosclerosis in vivo by employing mouse models that allow the inducible genetic manipulation of different components of the glucocorticoid-induced signaling axis, b) by utilizing the full heavy and light chain nucleotide sequences from our single cell BCR-seq data, to clone and produce the respective antibodies of the B-MIracle clones and examine their effect in accelerated atherosclerosis after MI in vivo, and c) to address the relevance of these findings in atherosclerosis progression in patients with a recent MI, by analyzing sorted peripheral B cell subsets and ser