RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Visualising neuronal signalling dynamics within intact neuronal circuits:  Deciphering the role of cell-specific MeCP2 dynamics in neuronal function and dysfunction' (2021-2027).

assistant: **Innovation**

Epigenetic signalling pathways are required to translate external sensory input to neuronal gene modulation and function, and disruption of epigenetic signals leads to devastating brain pathologies. One prominent example is Rett syndrome (RTT), a postnatal neurodevelopmental disease which results in rapid deterioration of sensory, motor, cognitive, and social functions. RTT is caused by loss of function mutations in a single gene encoding for Methyl-CpG binding protein 2 (MeCP2), an abundant and multifunctional methylation reader in the brain. While transgenic mouse models of MeCP2 loss have provided significant insights into RTT, they also revealed the vast complexity of the regulation of MeCP2 signalling and cell- specific heterogeneity. Importantly both a deficit and a surplus of MeCP2 give rise to pathological phenotypes. Here, we will develop an imaging-based approach to monitor endogenous MeCP2 signalling and dynamics in intact neuronal circuits in awake behaving mice. We will combine CRISPR/Cas9 genome editing to fluorescently label endogenous MeCP2 with FRET based biosensors to detect dynamic MeCP2 signalling without perturbing its innate regulation. In vivo two-photon fluorescence lifetime imaging will enable dual imaging of MeCP2 signalling and concurrent neuronal activity. Using this approach, we will map the functional landscape of MeCP2 activity in the intact mouse brain across cell-type, circuit, and sensory experience. We will also image in vivo MeCP2 signalling in transgenic mice with common RTT mutations. This will allow us to detect early cell-type specific MeCP2 dysfunction and avoid broad late-stage RTT symptoms. The direct visualisation of the intricate interplay between MeCP2 signalling and neuronal function within intact neuronal circuits will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Capacity for change and adaptation of schools in the case of effect iveschool improvement' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objectives are specified in terms of an alternation of empirical and theoretical projects, two of which are short term projects and the third a long term intervention project: 1. clarify the factors that impede and that foster effective school improvement (ESI) in primary and secondary schools; 2. integrate those factors in a comprehensive theoretical framework that provides a theoretical explanation of the factors that impede or foster ESI; 3. develop an ESI-intervention programme that stimulates ESI on a broad scale and in circumstances of various EU-member states, making use of the theoretical framework: 4. monitor the implementation of the ESI-intervention programme and evaluate its impact quasi experimentally in EU-member states; 5. provide schools in EU-member states with examples of good practice of ESI. The first project - to be conducted from 1996 to 1998 - concerns the inventory and the evaluation of the impact of ESI-programmes in the EU-member states, ESI being identified as spearpoint for developing scientific and practical knowledge beyond the present state-of-the-art in educational innovation and educational effectiveness. The objectives of this project are to identify good practices of ESI (5) and to clarify factors that impede and that foster ESI (1). As second project - also to be conducted from 1996 to 1998 - a theoretical analysis of ESI is proposed that combines the improvement and the effectiveness paradigms as well as relevant other theories. The objectives of the theoretical analysis are to clarify the factors that determine resistance to change and that impede ESI and to clarify the means to improve the schools' capacity for change and factors that foster ESI (1). The analysis aims also at the integration of relevant theories and paradigms i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Probing molecular interactions by fluorescence resonance energy transfer using periodic ground state depletion' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Fluorescence resonance energy transfer (FRET) techniques offer a new and unique approach for evaluating molecular interactions within cells, and have led to breakthroughs in our understanding of DNA structures. The objective of the proposed research is to extend the current FRET techniques to offer the capability for continuous observation at a high temporal resolution. The innovative aspect of the method described in this proposal is that it will minimize the probability of irreversible destruction of the donor or acceptor, which cannot be achieved with the current photobleaching FRET techniques. The proposed concept will be implemented on a confocal microscope imaging system allowing the mapping of energy transfer efficiencies on a pixel-by-pixel basis. The method will be used to study nucleic acid interactions, and protein-nucleic-acid interactions in an interdisciplinary effort with other scientists in the host laboratory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Water Cultures of Italy, 1500-1900' (Water-Cultures) targeting Horizon 2020.

assistant: **Abstract**

Behind this project lies a paradox: water, although vital for life, has historically had little intrinsic value. Considered base and common as a drink, it was nevertheless the most symbolically charged of the elements; of limited monetary value in and of itself, access to it was in fact hard-fought, the foundation and driving force of society. The Water Cultures project aims to create a new field of study, based around the social and cultural history of a people’s polyvalent interactions with water, applicable to a wide range of places and times.The project proposes an epistemological method of structuring, analysing and presenting the diverse range of findings and approaches into a new holistic understanding. The Water Cultures concept is based on the synergistic braiding of five key 'Streams': the symbolic beliefs and practices associated with water; the circulation and evolution of knowledge about water and disease and its effects; the water management systems of large cities and demands on them; the changing hydraulic landscape of rural areas; and the occupations of water, exploring the professions and trades associated with water and its delivery and uses. Italy has been chosen as the case study—for its rich archives and social, political and geographical variety. The Italian history of water, from the 1500s to the end of the 19th century, is a story of authority and conflict, social hierarchy and material realities, changing medical and scientific knowledge and technological expertise, and religious beliefs and practices. Yet Italian historians have undervalued water and its uses.This transformative project conceptualises a new way of writing history, with water at its core. It proposes the history and culture of a given society, the construction of identities and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'REsilient WAter Innovation for Smart Economy' in the context of a Horizon 2020 call.

assistant: **Objectives**

REWAISE will create a new “smart water ecosystem”, mobilising all relevant stakeholders to make society embrace the true value of water, reducing freshwater and energy use, resulting in a carbon free, sustainable hydrological cycle, to transition into a resilient circular economy. A network of nine living labs, involving 5 major water utilities, demonstrates real-life, large-scale operational environments for technological innovations and new governance methods to secure a resource-efficient water supply for the EU. New business niches will be created, incentivizing water-related investments, and accelerating SME growth, by linking users with specific water needs, incorporating life cycle and cost assessments, and collective action in new governance frameworks for smart value creation and high social returns. By incorporating paradigm shifts from a linear Roman heritage to a new circular, water-smart economy, REWAISE reveals the full Value of Water for Europe, considering 3 key components of the economic and societal value generated by integral water cycles:•            Value in Water: is accomplished by extracting and putting to beneficial use dissolved substances such as nutrients, minerals, chemicals and metals, as well as organic matter and energy, embedded in raw and used water streams.•            Value from Water: encompasses the economic activities inherent to the water cycle, related products and services that generate benefits and jobs, directly or in other sectors that depend on water, such as energy and transportation, •            Value through Water: the societal, health and well-being functions of water, which will be enhanced by inter-linking users, regulators, water operators and other stakeholders in electricity and chemicals markets through a digital
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sustainable Production of Industrial Recovered Energy using energy dissipative and storage technologies' under Horizon 2020.

assistant: **Concept**

SusPIRE project assimilates in its conception  the sustainable energy use challenge  described in the European SETPLAN and in SPIRE road map. It addresses its efforts to energy intensive industries and within this segment market to energy recovery from residual heat streams. To achieve this goal a two clearly differentiated working areas will be key aspects of this project. Technology area will include the development of materials and equipments. New Heat Transfer Fluids (HTF) and Phase Change Materials (PCM) will be the base for manufacture high efficiency heat exchangers in terms of energy capture and storage. Two Borehole Thermal Energy Storage (BTE)  areas(low temperature range (30-50ºC) and medium (50-80ºC)  will support a energy cascading  concept where energy will be sequentially used and finally stored for further use or commercialized to third parties. The methodology aspects of this projects wants to establish a framework to foster the energy commercialization of surplus energy . Living areas , symbiosis with other companies in industrial parks, sports centers.. will beneficiate from cheaper energy, environmental impact reduction and social acceptance of energy intensive industrial activities. The coordination of the manufacturing and the energy recovery processes will be carried out by means of a smart methodology. A protocol definition software will deploy actions to create best practices in terms of process adjustment and operating instructions. Management concepts based on energy recovery rate as Key Process Indicator (KPI), will be integrated into the decision making mechanism of the company assuring permanent advances in this field of activity in forthcoming years.


**Keywords:** Industrial heat recovery, energy intensive industry, underground thermal s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for ''Visual and Instrument Take-Off and Landing Maneuvers with EGNSS and Copernicus'', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

'Visual and Instrument Take-Off and Landing Maneuvers with EGNSS and Copernicus'Vertiport accessibility in all weather conditions, and the integration of VCA operations at airports, not interfering with already existing traffic (mainly aircrafts), are seen as major elements to be taken into consideration for the success of IAM (Innovative Air Mobility) operations and services.  Today EGNSS provides accurate navigation capability, without requiring any specific ground infrastructure, to civil aviation users.  Equally, EGNSS will be a key enabler to develop highly accurate VCA flight procedures in both, visual (VMC) and instrument (IMC) metereological conditions: - for busy airports where VCA and aircraft traffic need to be segregated to optimize the airport capacity: highly accurate flight procedures will allow fully independent operations between aircraft and VCA traffics on busy airport, without blocking runway slots reserved for transport aircraft, and vice versa; - for isolated vertiport, heliport, landing location where VCAs will need to be integrated based on current airspace structure, with highly efficient flight paths, minimizing the noise footprint and avoiding most populated areas through higher levels of flexibility. The implementation of these new VCA flight procedures has to take into account the expectations at environmental level, especially regarding the noise footprint reduction. Indeed, these new procedures might be implemented above urban areas and consequently the noise impact is a major aspect to consider, in particular towards public acceptance. In addition, flight efficiency in terms of power consumption should be prioritized to minimize any impact on flight endurance.  The current proposal includes the development of low noise flight criteria and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative high VOLTage network battery concept' (VOLT) targeting Horizon 2020.

assistant: **Abstract**

The VOLT Consortium will develop an innovative high voltage network (using 270 VDC) inspired by a Clean Sky architecture. This new architecture requires an innovative battery solution that will provide mainly pre-flight and starting power to the rotorcraftThe objective of  VOLT is to demonstrate their ability to:• Propose to the aeronautical industry an innovative battery concept for a High Voltage Network battery (HVNB) using an array of commercial available off-the-shelf battery cells with smart controllers rather than a single massive specific cell thus providing a far more reliable approach than classic solutions• Design, develop and manufacture a battery prototype (TRL6) and charger according to the technical, physical, and stringent environment requirements as defined in the call text• Perform the necessary stringent battery testing required before being qualified for flight testing and provide a monitoring and troubleshooting software easily used by unqualified operators• Prepare in parallel to the above mentioned research work performed in this project, the necessary pre-industrialization work to be able to meet future production demands of the VOLT battery.As of January 1st, 2020, ZEL is replaced by SEP due to partial takeover.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Integrating reinforcement learning and predictive control for smart home energy management'.

assistant: **Innovation**

To achieve carbon neutrality and reduce the dependence on fossil energy, solar panels, heat pumps and electric vehicles (EVs) are becoming commonplace in European homes. The abundant solar power, geothermal energy, as well as environmentally friendly electric vehicles, reduce the usage of fossil-based energy, while posing challenges to the home energy management system at the same time due to the intermittent feature of renewable energy and potential battery degradation from EVs. In this proposal, we propose a smart home management system that optimises the entire home energy cost while considering a set of constraints related to battery safety and reliability, driver/household demand and actuator. As an MSCA-PF fellow, Dr. Meng Yuan will receive crucial training at the Chalmers University of Technology and engage in battery power control and home energy optimisation works which span the areas of control theory and electrical engineering. Interaction between different areas will spur novel methodologies and fruitful outcomes including 1) an adaptive and robust power controller for EV battery systems, 2) a learning-based energy management algorithm that minimises the total energy cost while satisfying the household power supply, and 3) a safe learning-based control framework for home energy system management. The foreseeable results of the project will include a health-aware optimal control for vehicle battery systems that enables vehicle-to-home technology and prolongs the battery's lifetime; a new interdisciplinary energy management system combining machine learning and control algorithms to revolutionise energy sectors.


**Keywords:** Smart homes, electric vehicles, home energy management, model predictive control, robust control, reinforcement learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of fully dissolvable devices and application as implanted neuroprostheses' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Restoring sensory and motor human functions is the main goal of Neuroprosthetics. The development and integration of artificial devices with neural tissues is therefore a very important research branch, which aims at improving the quality of human life. Recently, many advances have been made in this field by exploiting implantable organic devices able to accomplish a specific task inside the biological environment and last as much as possible before being removed.Within this scenario, the project aims at pushing the current state-of-the-art of Neuroprosthetic further by implementing a concept of ‘Edible Neuroprosthetics’, which consists in bio-electronic devices able to be literally digested by the cellular environment of the host after they have achieved their target. Novel fully biodegradable microelectrode arrays will therefore be fabricated on flexible substrates by implementing highly biocompatible and edible materials with innovative soft fabrication techniques. Their deterioration rate and change in the mechanical and electrical properties will be assessed with in-vitro ageing studies, followed by in-vivo tests in order to supply a proof-of-principle for future clinical applications.The inter-disciplinary and innovative aspects of the project will have a profound effect on the personal scientific background of the applicant as well as on her future career as independent researcher. The new skills she will acquire together with the new techniques she will learn and the wide scientific network she will actively be involved in will contribute to the formation of a strong and versatile research figure in Neuroprosthetics. Moreover, the results will provide unprecedented insight within the edible device concept, therefore making an important breakthrough, which will d