RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HUMAN-MACHINE INTERACTION NETWORK ON EMOTION' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

HUMAINE aims to lay the foundations for European development of systems that can register, model and /or influence human emotional and emotion-related states - 'emotion-oriented systems'. Such systems may be central to future interfaces, but their conceptual underpinnings are not sufficiently advanced to be sure of their real potential or the best way to develop them. One of the reasons is that relevant knowledge is dispersed across many disciplines. HUMAINE brings together leading experts from the key disciplines in a program designed to achieve intellectual integration. It identifies 6 thematic areas that cut across traditional groupings and offer a framework for an appropriate division of labour - theory of emotion; signal/sign interfaces; the structure of emotionally coloured interactions; emotion in cognition and action; emotion in communication and persuasion; and usability of emotion-oriented systems. Teams linked to each area will run a workshop in it and carry out joint research to define an exemplar embodying guiding principles for future work in their area. Cutting across these are plenary sessions where teams from all areas report; activities to create necessary infrastructure (databases recognising cultural and gender diversity, an ethical framework, an electronic portal); and output to the wider community in the form of a handbook and recommendations of good practice (as precursors to formal standards).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Serotonin and BEYOND: Brain development research Excelling Young Ones in Neurotechnologies and Discoveries' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Serotonin is a neurotransmitter playing a crucial in the onset and treatment of neuropsychiatric disorders. Most of the drugs currently used in psychiatry target serotonin (neuro)transmission. However, it is becoming increasingly clear that the efficacy of these drugs is suboptimal. As a result, the prevalence and burden of these disorders remain high. A new wave of research revealed that serotonin plays important role in neurodevelopment. Changes in serotonin levels lead to changes in developmental processes with consequences for the serotonin system and beyond. This makes it plausible that the origins of these disorders do not per se lie in disturbed serotonin neurotransmission, but rather in serotonin-mediated neurodevelopmental changes. This would require a radical different view on disease burden reduction. We hypothesize that it are the serotonin-mediated non-serotonergic downstream changes in neurodevelopment that are at the basis of serotonin-related neuropsychiatric disorders. SEROTONIN and BEYOND will establish an interdisciplinary, intersectoral and international scientific network to test this hypothesis. It will enable paradigm shifts in the understanding of vulnerability to neuropsychiatric disorders, and provide groundwork for critical windows in development for future interventions. To achieve these goals, top-class academic and industrial scientists will train Early Stage Researchers (ESRs) in the full spectrum of state-of-the-art neuroscientific technical approaches. We will also equip these ESRs with translational and entrepreneurial thinking by providing intersectoral and transferable skills training. In summary, we will train a new generation of ESRs in the integrated field of serotonin, neurodevelopment and psychiatry to deliver 15 excellent young
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Two-dimensional acquisition for top-down native mass spectrometry of non-covalent protein complexes.' to be submitted under Horizon Europe.

assistant: **Abstract**

Native mass spectrometry (MS) is a powerful structural biology tool to study protein complexes, their dynamics, assembly and function. In its so-called top-down approach, it aims to link specific proteoforms to higher assemblies such as non-covalent complexes, in which they function naturally and/or in a disease. The proposed project will leverage the power and versatility offered by state-of-the-art Fourier transform ion cyclotron resonance (FTICR) mass spectrometry coupled to ultraviolet and infrared laser ion activation techniques to advance native top-down MS of large protein- and protein / nucleic acid complexes. Studying a range of protein complexes up to small viral capsids, the project will push the boundaries of FTICR MS in the analysis of high-mass protein complex samples. Utilizing both standard commercially available protein complexes for method setup and benchmarking as well as biologically-relevant FOXO, TEAD and nucleosome protein / DNA complexes from the host laboratory, advanced laser- and electron-induced dissociation and fragmentation techniques and their combinations will be tested to obtain the best possible information on multiple levels of the complexes structure. Finally, the hitherto untried combination of native MS of non-covalent protein complexes with two-dimensional MS acquisition schemes will be explored to probe all species in a heterogeneous mixture at the same time. Linking the obtained sequential information on proteoforms to their complex and subcomplex stoichiometry, this approach will help increase the utility of native MS as a powerful technique for the study of proteoforms and protein assemblies applicable to a broad range of biologically / medically relevant samples promoting and reinforcing the position of native MS in the modern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tracing the inFLUenza vaccine imPRINT on immune system to identify cellular signature of protection' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Influenza virus causes a large socioeconomic burden on society, with 70 000 deaths every year in Europe. It is estimated that 1 in 1000 children and elderly every year are hospitalized due to influenza infection. Children, due to high susceptibility and high levels of shedding, are the main source of spread of the virus. Therefore, CDC in 2010 included children as a high priority group for influenza vaccination. Two influenza vaccines are licensed: inactivated (IIV) and live attenuated (LAIV) vaccine. The LAIV was introduced to provide broader protection by additional stimulation of T cell responses. At present the two major obstacles in the widespread use of LAIV are concerns raised over vaccine effectiveness and the lack of immunological correlates of protection. In 2016 the CDC in the US recommended against the use of LAIV due to its poor effectiveness in the 2015/2016 season. However, the same vaccine, in the same season had high effectiveness as assessed by UK and Finland public health authorities. Currently the reason for this discrepancy is not known. This project will take advantage of cohorts of children who have received LAIV provided by both US and UK sponsors, to investigate the immunological basis for the observed variability and to define the role of adaptive immunity by applying the systems biology tools and machine learning algorithms for predictive modelling. Progress in the clinical investigation of children has been hampered by limited methods that could be applied to the small blood volumes, but recent advances in systems biology have opened new opportunities that did not exist before. Tracing the influenza vaccine imprint on immune system, termed FluPRINT by the proposed project will help to identify cellular signatures of vaccine-induced protection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metal-Functionalized Cavitands for a Site-Selective C-H hydroxylation of Aliphatic Compounds' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Selective hydroxylation of abundant, but chemically inert C-H bonds remains one of the great challenges in modern chemistry. Given that the resulting alcohols can easily be converted into a variety of other functional groups, this process is key to the large-scale production of commodity chemicals from a natural feedstock. Consequently, developing sustainable and environmentally benign catalysts capable of performing this transformation by utilizing cheap oxidants is of utmost importance. Such catalysts must be reactive enough to overcome the chemical inertness of C-H bonds, yet avoid over-oxidation, and be able to distinguish the target reaction site from other C-H bonds present.  Although in recent decades significant progress has been achieved in catalytic hydroxylation of methane and ethane, selective hydroxylation of heavier alkanes (as well as of alkyl chain residues particularly at the terminal position) is still only possible by natural metalloenzymes. While being environment-friendly and functioning under mild conditions, these natural catalysts are poorly applicable to large-scale industrial processes due to their low stability and high cost. Nevertheless, the underlying principles such as (1) reactive metal centers embedded in hydrophobic pockets, (2) structurally defined reaction environment, and (3) affinity-based differentiation between substrates and products, can be capitalized upon for constructing a new generation of synthetic catalysts.The project will demonstrate how these rationales can be implemented with novel metal-functionalized cavitands – inner cavity containing molecules with a rigid metal-binding site accessible only from their interior. This fresh design combines the oxidative power of high valent metal-oxo species with the chemoselectivity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced mapping, risk assessment and nature-based depollution methods are combined to accelerate the recovery of contaminated soils and ensure that ecological restoration enters mainstream business' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

EDAPHOS proposes a holistic and innovative land management approach to contribute to the Mission “A Soil Deal for EU” and to its specific objective “Reduce soil pollution and enhance restoration”. EDAPHOS will develop a framework for land rehabilitation and ecological restoration of contaminated areas featuring nature-based solutions (NBS) technologies, to accelerate the recovery of contaminated lands to a healthy ecosystem status and making ecological restoration a mainstream business endeavor. EDAPHOS will improve the monitoring of contaminated soils and the understanding of precise pollution sources at selected EU regions by combining robust remote sensing tools and GIS-based methods that will be applied at representative territorial lands. Site-specific risk assessment methods and metrics, based on the TRIAD concept and considering the sources, the pathways, the exposure and effects of soil pollution, will be developed and applied on 7 case studies. EDAPHOS will perform lab and field studies to validate the technological readiness and the cost-effectiveness of NBS as effective remediation strategy for reducing soil contamination in urban, peri-urban and rural settings and land uses. EDAPHOS will assess the environmental, social and economic impacts of selected NBS sites and will develop the most suitable quantitative metrics and KPIs that depict accurately and reliably their integrated socio-environmental performance in both terms of economic benefit (e.g. growth of ecosystem services value, final phytoremediation compounds for further industrial valorization) and cost prevention (e.g. environmental footprint reduction) potentials, along with tailored ecological finance instruments for establishing a self-sustained and replicable EU NBS market. With the aim of provi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Type 1 Diabetes Self-Management and Carbohydrate Counting: A Computer Vision based Approach' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Patients with diabetes must be taught how to achieve glycaemic control by monitoring their glucose levels properly. They are medicated with either exogenous insulin or other drugs and encouraged to improve their diet and physical activity. Although studies have shown that planning meals and counting carbohydrates is of great importance for diabetic patients, even well trained diabetic patients find it difficult to estimate carbohydrates precisely.The aim of the project is the design, development and evaluation of a system which will permit the automatic, near real-time recognition of the different types of foods on a plate and the estimation of their content of carbohydrates. The system will be based on the advanced analysis of colour images and will be composed of i) an Advanced Image Processing (AIP) module, including a camera for image capture, ii) a Carbohydrate Estimator (CE) and iii) a Data Base (DB). The AIP module will incorporate the entire image processing tools for acquisition, preprocessing, segmentation, feature detection, feature representation and selection, and classification. The CE will estimate the volume and the weight of the food, while the DB will contain a list of nutrients, along with the corresponding grams of carbohydrates. In a typical use scenario, the diabetic will take a picture of the incoming meal with the mobile phone camera. This image will be processed in order to estimate a set of characteristic features describing the type of nutrition and the corresponding grams of carbohydrate. In addition to dietary assessment, this information will be used to optimise the calculation of the bolus insulin dose.The ultimate objective is to have an application running on a portable device which can be used in everyday life to support the diabetic pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Promotion of Short Sea Shipping and Inland Waterway Transport by use of Modern Telematics' (PROSIT), addressing dissemination and exploitation.

assistant: **Impact**

PROSIT is attempting to achieve several goals:- Support an intermodal brokerage for linking and tuning the demand and supply side in transport including short sea shipping and inland waterway transport;- Improve quality and reliability of short sea shipping and inland waterway transport and it s integration into intermodal transport chains;- Establish a monitoring system for the entire transport chain, after sales service, reporting deviations, activating fallback solutions and by doing so assist to guarantee quality and reliability required for the sustainable acceptance of short sea shipping and inland waterway transport on the market. %- Southern Finland- Northern Germany- Western Germany- Great Britain- Spain- Greece %INFOLOG, BOPCOM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pathophysiology of Primary Aldosteronism' (PAPA).

assistant: **Concept**

Arterial hypertension is a major cardiovascular risk factor that affects between 10-40% of the population. Primary aldosteronism (PA) due to adrenal excess production of aldosterone is the most common secondary form of hypertension affecting 4-12% of hypertensives. Given the severe cardiovascular adverse effects of aldosterone excess early detection and individualized treatment of PA has important impact on clinical outcome and survival. However, the pathophysiology of PA is not well understood: While we recently identified specific genes underlying aldosterone producing adenoma, the most prevalent form of PA, bilateral adrenal hyperplasia, has remained enigmatic. It is the first hypothesis of this proposal that the pathophysiology of PA is a process based on two ‘hits’: agonistic angiotensin II type 1 receptor (AT1R) autoantibodies (proliferation, nodular hyperplasia) and somatic mutations (adenoma formation). It is the second hypothesis, that together, both factors induce not only aldosterone but also marked glucocorticoid excess.1.) I will analyze prevalence and binding characteristics of AT1R autoantibodies as a pathophysiologic basis of PA. 2.) I will determine the effect of AT1R antibodies and genetic factors on cellular adrenal cortex models in vitro. 3.) I will extend these studies to specific in vivo genetic rodent models of PA. 4.) I will quantify aldosterone and glucocorticoid excess as disease effectors of AT1R autoantibodies and somatic mutations using liquid chromatography–mass spectrometry in PA. 5.) Using the generated data I will develop a pathophysiology-based concept of PA.This groundbreaking approach using innovative in vitro and in vivo models, state-of-the art genetic, immunologic and steroidobolomic techniques will uniquely open new avenues to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Strongly correlated fermions in optical lattices with single-site resolution' to be submitted under Seventh Framework.

assistant: **Abstract**

Ultracold atoms in optical lattices offer previously unparalleled possibilities to simulate quantum many-body effects with almost full control and detection at the single particle level. Recently, in-situ-imaging with single-atom resolution has become available for bosonic rubidium atoms, but an experimental demonstration of the single-site-resolved detection of fermions is still missing. The aim of this research project is to detect and to manipulate strongly correlated fermionic quantum systems in an optical lattice by means of a specially designed microscope objective with single-site and single-atom resolution. This will allow us to simulate several seminal models of condensed matter physics, in particular the Fermi-Hubbard model, which is conjectured to be a key model for high-Tc superconductivity.  Probing strongly correlated systems at this most fundamental, single-particle level is a fantastic advantage over the present techniques which use time-of-flight images. Gaining access to the in-trap atom distribution of the fermions with single-atom resolution will enable the precise characterization of spatial order, temperature, and entropy distribution of fermionic many-body states, such as fermionic Mott insulators, band insulators, metallic phases or Néel antiferromagnets. Furthermore, spin manipulations on the scale of individual lattice sites can locally perturb the system, and the ensuing dynamical in-trap evolution can be recorded with unprecedented resolution. By simulating condensed matter systems with ultracold fermionic atoms in optical lattices, this project will help to make Richard Feynman’s vision of a quantum simulator become a reality.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Mosquito Antiviral piRNA Pathway'.

assistant: **Objectives**

Mosquitoes transmit several medically and economically important ARthropod-BOrne (arbo)viruses to mammals (including humans), such as dengue virus and chikungunya virus (CHIKV). Unlike infection in their mammalian host, infection in their arthropod vector is apathogenic and persistent due to the interplay between the virus and the innate immune responses. The main antiviral mechanism in mosquitoes is the sequence specific RNA break down mechanism- RNA interference (RNAi), specifically the 21 nucleotide (nt) long small interfering (si)RNAs are considered to play a key role; however, siRNAs are not likely to be essential for the establishment of persistent viral infection. Recently small RNA molecules derived from different pathway have been reported to have an antiviral role in aedine mosquitoes and derived cell lines: PIWI interacting (pi)RNAs (24-29 nt). Persistent infection ensures that mosquitoes remain infectious and if piRNAs control this process, they could play a key part in regulating subsequent arbovirus transmission to humans. Little is known about the piRNA pathway in mosquitoes and even less about its interaction with arbovirus infections. Most of the work has focused on the identification and analysis of (viral specific) small RNAs (siRNA and piRNAs) in infected mosquitoes, but little on the proteins and the protein-RNA interactions involved in these processes.The proposed research project will use a multidisciplinary approach that involves molecular virology with CHIKV, quantitative proteomics, RNA sequencing and knock down experiments in Aedes aegypti derived cells and mosquitoes to comprehensively understand for the first time the piRNA pathway, its involvement and importance to regulate arbovirus infections in aedine mosquitoes. The findings will extend