RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'WhiteRabbit: easily revealing and managing personal information.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

WhiteRabbit aims to bring to the market an innovative software platform. The platform will allow to extract value from personal data, while keeping its subjects in the loop and also complying with upcoming regulations.In the last 20 years the use of personal data generated a big but not still well-regulated market; this has resulted in problems to companies and SMEs like the escalating complexity of data privacy management, the misuse of data and its social/legal consequences. The upcoming General Data Protection Regulation (GDPR) in Europe, with its stricter rules, will introduce even higher complexity and costs for the management of personal data. In an ideal comparison with a well-known and regulated sector, the new software platform introduced by WhiteRabbit will work as an automated “tax accountant” helping companies to effectively deal with the complexity of regulations related to “tax returns”.Based on the prototype developed by the University of Trento within the “Smart Society” FET project, the WhiteRabbit project will bring such prototype to a further step of development through a new partnership with META Group, a leading company in the field of exploitation of research results, start-up creation, and access to finance. WhiteRabbit will validate the business model and design a commercialisation roadmap for the new start-up that will be launched by the team who developed the software platform’s original prototype. The consortium will then test the product in a market environment and finally will foster growth opportunities by pitching it to investors and potential customers.WhiteRabbit will generate an impact in terms of an innovation introduced into the market (the platform), the improvement of entrepreneurial mind-set (researchers becoming entrepreneurs with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Safe abandoning of ships, Improvement of current Life Saving Appliances Systems (SAFECRAFTS)' (SAFECRAFTS), addressing dissemination and exploitation.

assistant: **Impact**

Issue Provide safety improvement of the evacuation system in terms of passenger/crew survivability by conceptual improvements of current lifesaving appliances (LSA). A tendency to develop passenger vessels carrying more than 5000 passengers can be seen. A major calamity, such as flooding or fire, would have catastrophic consequences. Special focus should be given to means of rescue. Little scientific evidence is available on the effectiveness of LSAs in realistic conditions. No technical evidence seems to be available on the performance of the rescue system, i.e. hardware and procedures/management. Analysing the rescue process as a whole and considering non-conventional measures, might increase the effectiveness of safety investments and save space on board. Moreover, the success rate will improve dramatically. Model scale and full scale tests of novel rescue system concepts under extreme weather conditions, will be required, a full scale test prototype will be developed in order to obtain evacuation success rates. Objective How to improve current LSAs This project is emphasising on the rescue process by both quantifying the performance of the LSAs and improving the concept of reaching the rescue vessel in a safe and reliable manner. The challenge is to exploit a first principles approach (regarding hydromechanics, mechanics, human behaviour, quantitative risk assessment and emergency management) in the design of rescue systems for passengers and crew, addressing both hardware and procedures/management. Aim must be to prove attained safety levels acceptable to the EC. Stated safety levels must be supported by sound scientific evidence. In this respect physical model tests and full scale tests will play a decisive role. Benefits Safety improvement and acceptance of rescu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Role of Atg8 Posttranslational Modifications in Autophagy' under Seventh Framework.

assistant: **Concept**

Autophagy is an important cellular degradation pathway required for eukaryotic protein homeostasis. Deregulation of autophagy has been shown to cause the development of various human pathologies, including aggregation diseases and cancer. Autophagy involves the formation of double-membrane vesicles, called autophagosomes, which sequester portions of the cytosol (general autophagy) or whole protein aggregates, organelles or pathogens (selective autophagy). Autophagosomes then fuse with the lysosome or vacuole, where the cargo is degraded. Atg8 is a key regulator of autophagy facilitating autophagosome formation, lysosomal fusion and cargo recruitment. Atg8 is conjugated to the lipid phosphatidylethanolamine and is thereby inserted into the arising autophagsomal membrane, in which it promotes autophagosomal membrane expansion and cargo recruitment through direct binding of LIR-motif containing cargo adaptors.Interestingly, large-scale proteomics data suggest that Atg8 is regulated by several posttranslational modifications (PTMs). Here we propose to study the functional implications of these Atg8 modifications for general and selective autophagy. Intriguingly, our preliminary data suggest that Atg8 undergoes Atg1- and Atg7-dependent polyubiquitination. We propose that Atg8 polyubiquitination may cause a switch from selective to general autophagy to promote cell survival or, alternatively, that it may play a role in autophagosome-vacuole fusion. Moreover, we will investigate the enzymatic machinery and regulatory mechanisms underlying Atg8 PTMs. We anticipate bridging the knowledge gap between large-scale proteomics data and essential functional and mechanistic understanding of Atg8 PTMs. Based on our promising preliminary data, we are confident that this study will provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Atomistic Spin-Dynamics; Methodology and Applications'.

assistant: **Concept**

Our aim is to provide a theoretical framework for studies of dynamical aspects of magnetic materials and magnetisation reversal, which has potential for applications for magnetic data storage and magnetic memory devices. The project focuses on developing and using an atomistic spin dynamics simulation method. Our goal is to identify novel materials and device geometries with improved performance. The scientific questions which will be addressed concern the understanding of the fundamental temporal limit of magnetisation switching and reversal, and the mechanisms which govern this limit. The methodological developments concern the ability to, from first principles theory, calculate the interatomic exchange parameters of materials in general, in particular for correlated electron materials, via the use of dynamical mean-field theory. The theoretical development also involves an atomistic spin dynamics simulation method, which once it has been established, will be released as a public software package. The proposed theoretical research will be intimately connected to world-leading experimental efforts, especially in Europe where a leading activity in experimental studies of magnetisation dynamics has been established. The ambition with this project is to become world-leading in the theory of simulating spin-dynamics phenomena, and to promote education and training of young researchers. To achieve our goals we will build up an open and lively environment, where the advances in the theoretical knowledge of spin-dynamics phenomena will be used to address important questions in information technology. In this environment the next generation research leaders will be fostered and trained, thus ensuring that the society of tomorrow is equipped with the scientific competence to ta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Shaping Conical Intersections for Intramolecular Proton Transfer' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Excited-state intramolecular proton transfer (ESIPT) - where proton transfer occurs after the absorption of a photon - is an important topic for the understanding of photoreactions in organic systems. The central aim of this proposal is to apply a unique combination of novel computational tools to understand such processes. We will study methyl salicylate (MS), a ‘floppy’ molecule with a slow proton transfer. Computationally, our first objective will be to map out the reaction paths and conical intersection seams accessible to excited states, characterised as critical points linked by minimum energy paths that preserve the degeneracy of the two states. Having determined the molecular geometries at which decay to S0 takes place, we will be able to suggest strategies to control the dynamics on the excited state. Multiple decay pathways make MS and related systems suitable for coherent control investigations; experiments which are planned by the experimental group of Prof. Fielding at University College London. MS is a challenge for quantum methods in which the dynamic electron correlation is cruzial for obtaining accurate excitation energies and realistic barrier heights. Our second objective is to compare the CASPT2 approach - which the applicant knows from his PhD- with the RASSCF one. Calculating CASPT2 energies at CASSCF geometries is a state-dependent approximation: there is the potential with RASSCF to go beyond this. There is scope to develop the projects further including environmental effects (QM/MM), or to study quantum dynamics. This fellowship proposal combines the experience of excited state calculations developed by the applicant with the complementary experience in computational methods of the host group. It will lead to new insights into the mechanism of E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Putting Water at the Centre of Nuclear Energy History' (NUCLEARWATERS) under Horizon 2020.

assistant: **Objectives**

NUCLEARWATERS develops a groundbreaking new approach to studying the history of nuclear energy. Rather than interpreting nuclear energy history as a history of nuclear physics and radiochemistry, it analyses it as a history of water. The project develops the argument that nuclear energy is in essence a hydraulic form of technology, and that it as such builds on centuries and even millennia of earlier hydraulic engineering efforts worldwide – and, culturally speaking, on earlier “hydraulic civilizations”, from ancient Egypt to the modern Netherlands. I investigate how historical water-manipulating technologies and wet and dry risk conceptions from a deeper past were carried on into the nuclear age. These risk conceptions brought with them a complex set of social and professional practices that displayed considerable inertia and were difficult to change – sometimes paving the way for disaster. Against this background I hypothesize that a water-centred nuclear energy history enables us to resolve a number of the key riddles in nuclear energy history and to grasp the deeper historical logic behind various nuclear disasters and accidents worldwide. The project is structured along six work packages that problematize the centrality – and dilemma – of water in nuclear energy history from different thematic and geographical angles. These include in-depth studies of the transnational nuclear-hydraulic engineering community, of the Soviet Union’s nuclear waters, of the Rhine Valley as a transnational and heavily nuclearized river basin, of Japan’s atomic coastscapes and of the ecologically and politically fragile Baltic Sea region. The ultimate ambition is to significantly revise nuclear energy history as we know it – with implications not only for the history of technology as an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'The role of small and medium-sized towns in rural development'.

assistant: **Concept**

Using a methodology previously developed and tested by one of the partners, this project measures the economic linkages between small- and medium-sized towns and the surrounding countryside in order to assess their present and potential role as growth poles in rural development. The methodology also provides an indication of the local employment and income impact of different types of economic activity in these towns and their surrounding hinterland. By studying a suitable sample of towns within different types of rural area and across a range of conditions in the existing and enlarged European Union, it provides soundly based advice to policy-makers at EU, national and regional level who are seeking to foster sustainable rural development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nuclear foundations of cellular potency' in the context of a Seventh Framework call.

assistant: **Objectives**

A fundamental question in biology is to understand the mechanisms underlying cell plasticity. Such plasticity or potency is essential to form multiple cell types upon differentiation. In mammals, upon fertilization and fusion of the gametes –two highly differentiated cells- intense chromatin remodeling and epigenetic reprogramming, the reversion into an undifferentiated state, are essential to restore full developmental potency (totipotency). Subsequent development and differentiation are accompanied with progressive loss of plasticity. The transition between totipotency and the gradual loss of plasticity is thought to be regulated by yet-unknown epigenetic mechanisms.The embryonic chromatin displays unique features compared to differentiated cells, including the lack of ‘conventional’ heterochromatin. We hypothesise that the transition from a totipotent state to a differentiated one is regulated by changes in chromatin states, particularly by de novo acquisition of heterochromatin domains.This project is designed to reveal the nuclear foundations of totipotency by determining the molecular mechanisms underlying the establishment of heterochromatin and their functional role in maintaining totipotency using the mouse embryo as model.We will do this by:i)determining the functional relationship of heterochromatin and nuclear architectureii)by determining the effects of artificially inducing heterochromatin on cell potency during development andiii)by determining the mechanisms that regulate heterochromatin formation in the embryo.We anticipate that our studies will unravel fundamental mechanims on how chromatin states regulate cell potency during reprogramming. By uncovering such mechanisms, we expect to reveal new insights that will be useful to induce epigenetic reprogra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genetic and Small Molecule Modifiers of Lysosomal Function' (LysoMod) targeting Horizon 2020.

assistant: **Abstract**

LysoMod will innovate in the area of personalized medicine for disorders linked to lysosomal dysfunction. This will be achieved by implementing a collaborative staff-exchange program between highly complementary and multidisciplinary academic and non-academic partners with expertise in pharmacology, medicinal chemistry, cell biology, biochemistry, mouse and human genetics, transcriptomics, proteomics and lipidomics. Based on the critical role that lysosomes play in cells, a better understanding of lysosomal function will have a major impact on human health, fostering the development of new strategies to improve quality of life for people affected by a variety of diseases, ranging from lysosomal storage diseases (LSDs) to age-related neurodegenerative disorders. LysoMod’s specific objectives are: 1) to develop and further optimize existing therapies for LSDs; 2) to identify new targets for personalized therapies for LSDs; and 3) to investigate the cross-talk between lysosomal function, signalling pathways and gene expression regulation. The pioneer work of a participant in the consortium led to the development of a drug that is approved for clinical use. LysoMod will i) investigate the mechanisms of action of this and other drugs in lysosome-related disorder; ii) identify modifier genes involved in LSD pathology and test their potential as new targets for personalized therapeutic approaches; iii) identify candidate RNAs that can be targeted to enhance lysosomal function. The companies in the consortium will ensure a rapid transfer of new knowledge into applications for diagnostics and clinical trials. Prioritising lysosomal dysfunction as a highly relevant biomedical problem, the LysoMod consortium will implement a mentored staff-exchange program to provide young researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Organic Phosphor for Efficient Remote LED Applications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

White light sources based on Inorganic LED is an emerging technology which will dominate the lighting market.  There remain significant research challenges before a high efficacy, high lumen output, retrofit lamp with high quality white light can be made at an affordable price. In mainstream LED lighting, white light is obtained from a phosphor layer which is placed on top of a blue light-emitting LED. OPERA will place the LEDs in a highly-reflective light-mixing chamber with the phosphor at the exit surface, reducing phosphor temperature to 80oC and light intensity 1000x less, inexpensive and wavelength-tunable organic phosphors used instead of costly and export-restricted rare-earth based inorganic phosphors. We introduce two new innovations improving the system efficiency: 1) Introduce a new set of organic phosphors with significantly higher efficiencies and long lifetimes (50000hrs). 2) Increase the efficacy of the LED light engine by replacing state-of-the-art inefficient light diffusers with efficient diffractive optics complemented with an improved reflectivity of the mixing chambers. OPERA will demonstrate a breakthrough in LED light engines which will DOUBLE the luminous efficacy of the state-of-the-art direct phosphor-converted LED modules. Resulting in two demonstrators: 1) LED engine with efficacy of 130Lm/Watt CCT 2700K with CRI 90 Incandescent 2) LED engine with efficacy of 150Lm/W at CCT 4000K with CRI 80 Fluorescent tube. The consortium addresses the research challenges associated with the remote phosphor optical configuration, efficient stable organic phosphor definition and components for light engine construction.  We give European industry an important role in design and manufacturing of optical components based on alternative phosphors for light con