RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interdisciplinary connectivity: Understanding and managing complex systems using connectivity science' (2014-2020).

assistant: **Innovation**

The goal of this ITN is to train a new cohort of researchers specialized in the developing field of connectivity science who will be capable of developing interdisciplinary approaches to connectivity across a range of disciplines and real-life applications in the next five to 10 years. Our overarching aim is to overcome barriers to progress in using connectivity science to understand and manage complex systems by learning from transdisciplinary perspectives to produce new insights into the behaviour of complex systems across diverse disciplines (Astrophysics, Computer Science, Ecology, Geomorphology, Hydrology, Neuroscience, Systems Biology and Social Science), and synthesize them into a common set of theories and approaches. To realise this goal, we define three research objectives each of which focuses on a specific challenge in developing connectivity: Objective 1) Developing the theoretical underpinning of connectivity science for applications in complex systems; Objective 2) Development of a unified framework of methods and approaches that can be applied across disciplines; Objective 3) Exploring applications of connectivity science to understand, adapt to and manage complex systems. A dedicated work package has been created for each research objective, and each one involves the key activities of the network: research, training, and knowledge and expertise dissemination. In addition, WP4 will have oversight of training, WP5 the management and WP6 the dissemination aspects of the network. Training of ESRs will include: - A network-wide training course in transferable skills will be specially developed and delivered by D-CAD (Centre for Academic Development at Durham), an award-winning programme supporting Early Career Researchers. - a bespoke series of five advanced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DOVETAILED MASSIVE WOOD BOARD ELEMENTS FOR MULTI-STORY BUILDINGS' under Horizon 2020.

assistant: **Concept**

In engineered wood products (EWPs), adhesives play an essential role particularly by helping save wood, making the structure light and robust, and moderating the expansion and contraction due to the inherent moisture. Although there are many advantages associated with EWPs, the use of adhesives causes some concerns about their sustainability, recyclability, and broader environmental impact. In addition to these detrimental substances, metal connectors used in EWPs have a negative impact on their end-of-life disposal, reusability, and recyclability.Thus, there is still room for a solution that is solid and completely pure wood enabling as healthy indoor air as possible (adhesive-&metal-connectors-free) dovetailed massive wood board elements (DMWBE) based on one of the oldest joining methods used traditionally.In the literature, numerous studies have been conducted on the technological, ecological, social, and economic aspects of EWPs in the construction with different building solutions, however, no studies have made an attempt to evaluate the technical performance of DMWBE in multi-story or tall construction. Overall, the aim of this research is to promote the competitiveness of Finnish large-scale industrial wooden construction at the local level and to create higher value-added circular economy opportunities in support of European climate policy as part of the bio-economy and sustainable development. To achieve this goal, DMWBE for multi-story buildings to the global market as a replacement of conventional EWPs e.g. cross-laminated timber, glue-laminated timber will be developed by enabling the confidence of its technical performance and suitability within the interdisciplinary collaborations among architecture, structure, and building physics. The following main obje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced kinetically controlled robotic system for orthopaedic diag nostics' (ROBOPED) under Fourth Framework.

assistant: **Objectives**

Occupational, trauma and sports related injuries, as well as degenerative joint diseases, are the most frequently occurring joint related problems, with roughly 20% of the population seeking medical care. According to medical statistics, it causes enormous health and additional costs due to reduced activities, disabilities, loss of work and school days, etc., which in Europe annually can be expressed in billions ECU's. Especially the prevention, diagnosis and treatment of knee injuries have been recognised as most critical due to large prevalence , knee joint complexity, and subjective diagnostic methods and tools. The objective of the ROBOPED project is to enhance the robotic control and sensor technology to be applied in an innovative, accurate and easy to use orthopaedic diagnostic system. The key new ROBOPED features for assessing knee performance are associated with; automatic functional examinations and calibration, advanced sensor based control (compliance, force), redundant non invasive sensory system ensuring a fault tolerant and efficient comfort testing, dynamic data processing, evaluation and depiction of test results based on recent big mechanics knowledge and clinical experience. The system will help better understanding of knee joint functions and pathogenesis, as well as improving the treatment and follow up of injuries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In-cell NMR monitoring of alpha-Synuclein aggregation in neuronal cells' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Intracellular aggregation of the human amyloid protein alpha-synuclein is causally involved in Parkinson’s disease, a debilitating neurodegenerative disorder. The goal of this project is to combine low-resolution, fluorescence-imaging methods with high-resolution in-cell NMR and EPR spectroscopy techniques to derive macroscopic and microscopic insights into alpha-synuclein aggregate structures directly in neuronal cells.   To achieve this goal, we will employ different sets of cultured neurons and investigate intracellular alpha-synuclein aggregation under defined conditions of mitochondrial dysfunction and cellular oxidative stress, two of the most common denominators of the disease. Importantly, we will also establish a human stem cell model for studying alpha-synuclein aggregation with high-resolution in-cell NMR and EPR methods, by using induced pluripotent stem cell (iPSC) derived dopaminergic neurons from Parkinson’s disease patients and control individuals.   Results from this study will provide novel insights into the native mechanisms of intracellular aggregate formation and ultimately enable novel pharmacological approaches for therapeutic intervention.


**Keywords:** Cellular Structural Biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tracing Neanderthal Territories: Landscape Organization and Stone Resource Management in South East France' to be submitted under Seventh Framework.

assistant: **Abstract**

The story of the Neanderthals has seen an explosion of interest over the past few decades, both in terms of scientific research and popular appetite for facts and narrative about this extinct human species. The recent revelation that Neanderthals made a significant contribution to modern human genomes has intensified the world’s focus, especially on their similarity to early modern humans. Contemporary research questions converge on the nature of Neanderthal adaptations, and the extent of cognitive parallels between the two species. In particular, were there any differences in how Neanderthals organized their lives on scales as large as entire landscapes?The TRACETERRE project aims to advance these key remaining questions by pursuing research using cutting-edge interdisciplinary methods on the Neanderthal archaeology (c. 60-30 ka BP) of South East France. This diverse region represents a key area where examination of the variability in Neanderthal landscape use and resource management can be characterized through analysis of stone tool (lithic) acquisition/exploitation and technology. These apparently elementary aspects of the archaeological record in fact derive from complex cognitive factors, which can reveal much about differences between Neanderthal and early modern human minds.TRACETERRE will for the first time apply petro-archaeological techniques to open-air sites, to determine the nature of Neanderthal landscape organization by accurately tracing lithics to their sources and integrating these sites into wider settlement systems. The project represents a unique opportunity for transnational collaboration to address key questions on Neanderthal territorial organization. Training in a pioneering new technique will diversify the scientific skills of the researcher,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Design and validation of a conductive polymer-based system for the functional maturation of human pluripotent stem cell derived cardiomyocytes as a platform for drug testing' (2007-2013).

assistant: **Concept**

Despite the burden cardiovascular diseases impose on patients and healthcare systems, a curative therapy is lacking. One of the primary limitations is the ineffectiveness of current drug testing methods, which rely on individual cells or animal models. These systems lack the necessary reliability, as shown by the high rate of attrition that additionally increases the cost of drug development. Although cell reprogramming technology has been suggested as a potential solution that opens the path to personalized treatments, its application to the cardiac field has been hampered by the lack of maturity of the obtained cells. Our aim is to develop a drug screening platform by combining the human pluripotent stem cell (hPSC) technology with novel conductive polymers in the fabrication of a biomimicking cardiac niche. We will couple the specific characteristics of the niche, including stiffness, presence of adhesion motifs, mechanical strain and patterning of the substrate, with hPSC-cardiomyocytes (CM). In addition to the unique and physiological electrical stimulation the conductive polymers will transmit, the biofabricated niche will potently drive the maturation of hPSC-CM towards an adult phenotype, truly relevant for the screening of drugs. Our approach will assess the efficacy of this technology using an array of techniques. Importantly, we will introduce for the first time live cell Raman microspectroscopy to the evaluation of the dynamic process maturation. In addition, the creation of reporter hPSC lines enabling the genetic selection of chamber (atrial/ventricular) specific CM will provide high capacity of modeling the requirements of different cardiac diseases, endowing our platform with an unprecedented capacity of success. This proposal has a highly multidisciplin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Non-invasive nanotransducer for in vivo gene therapy' (NINIVE).

assistant: **Innovation**

Nanotechnology is expected to have a major impact on biomedical research, leading to new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is the development of non-viral vectors for safe and efficient gene delivery. Progress in the Human Genome Project increases the attractiveness of gene therapy as a therapeutic modality for a host of diseases. Today the methodologies for in vivo gene transfection are still in their infancy. The most promising method is based on the use of viral vectors, but its safety is actually under discussion.This project aims at developing a nonviral vector for gene delivery, able of:a) gene transfection in vivo and on a large amount of cells,b) local and non invasive therapy,c) frequent and easy medication.This nano-device will be based on a carbon nanotube (CNT). It will be coated with genes to be transferred, and will be functionalised with a ligand, able to bind a receptor expressed by the target cells to be transfected. A solution containing a myriad of vectors will be dispensed locally in the target tissue, e.g. via injection; each of them will localise a target cell and bind it. Two strategies of cell transfection will be investigated: 1) cells up -take the vectors via endocytosis and 2) genes are transferred in the cell membrane via electroporation (i.e. via permeabilization of cell membrane by application of short-duration electric field pulses).In the second case, current impulses could be generated in CNTs via electromagnetic fields, by exploiting t he properties of CNTs like antennas. In order to prove these paradigms, in vivo validation of the nanotransducer vectors will be performed. A specific neurological disorder will be treated to demonstrate their therapeutic potential. The implementation of t his propo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Women Tech Europe Support Scheme' to be submitted under Horizon Europe.

assistant: **Abstract**

Entrepreneurship is crucial for economic growth and societal progress, yet women remain underrepresented in the field, accounting for less than a third of entrepreneurs in EU. This under-representation not only highlights inequality but also limits EU's potential to tackle pressing challenges, such as the digital, green, resilience transition, and recovery from the pandemic. Deep tech sectors are even less balanced, and investment for women-led companies remains less than 2% of the totalTo address this gender gap, Women TechEU will bridge collaboration between the European Commission and pan-European deep tech women-led startups to create a more gender-balanced entrepreneurship ecosystem. Built on the exisisting foundations of the EIC Women TechEU initiative, our consortium will scale this iniatiative with a clear perspective towards long-term sustainabilityWe will invest 12M€ in equity-free grants to 160 women-led deep tech companies and additional support services in a programme enhancing current EIC BAS to which we will linkThe consortium is comprised by partners covering all the expertise and geographies needed to reach over 15000 women entrepreneurs in deep tech from all over Europe. Led by EIT Manufacturing, it is strengthened with the participation of other KICs from EIT like Health, Food and Climate, leveraging the power of their network and landmark events. We also count with the expertise from Sploro in cascade funding programmes. Across Limits will guide the communication and dissemination activities as well as link in the service delivery with Awaken Hub, who will coordinate an effort to evaluate over 1500 experts in 4 different open calls. The consortium is complemented by major networks of investors and women entrepreneurs like EBAN, AFAEMME, or FIValues a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Twists & more: the complex shape of light'.

assistant: **Innovation**

My scientific career to date has centered around the phase and intensity shaping of light beams, specifically for the pioneering studies of Orbital angular momentum.I wish to build upon this foundation applying twisted and shaped light to sensing and imaging in both the classical and quantum domains.I will use orbital angular momentum as a new imaging modality and as the basis as a remote sensor of rotational motion.  I will used randomly shaped light beam as a new approach to 3D vision.  I will use the quantum correlations of orbital angular momentum and other spatial states to explore new demonstrations of quantum behaviour and deliver imaging performance beyond the classical limit.To realize this project, funding is sought for 2 FTE postdoctoral research assistants for 5 years and 3 PhD students who will work in close conjunction with myself.  I will devote myself to this project, both technically in the laboratory and in promoting the results of the program to international scientific, industrial and political peers.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synthetic biology-guided engineering of Pseudomonas putida for biofluorination' (SinFonia).

assistant: **Concept**

Nature has hardly evolved biochemical reactions involving fluorine (F), the most abundant halogen on Earth. Organic compounds containing F (fluorochemicals) are, however, extremely relevant from an industrial point of view. Fluoropolymers are the main fluorochemicals in the market worldwide, and are exclusively synthesized using chemical methods. Moreover, current fluorination technologies usually involve corrosive and toxic reagents that have a negative impact on the environment. Designing sustainable bioprocesses based on alternative and safer fluorinating agents from renewable substrates is thus a long-sought-after, yet unfulfilled goal. SinFonia proposes to engineer the metabolically-versatile bacterium Pseudomonas putida to execute biofluorinations for generating novel fluoropolymers from renewable substrates. P. putida KT2440, a non-pathogenic soil bacterium, serves as an ideal microbial platform for F-dependent biochemical reactions due to its extraordinary resistance to harsh and stressful operating conditions. SinFonia will exploit natural selection to enhance bioproduction through a smart strain engineering approach in which bacterial growth will be coupled to biofluorination. Our target compounds are a whole family of fluorinated polyesters with enhanced physicochemical and material properties, with uses as self-cleaning surfaces, low-surface-energy coatings, bio-based lubricants, membranes for fuel cells, and anti-fouling materials. The versatile P. putida strains engineered during the project can be easily adapted to synthesize other added-value fluorochemicals. Unlike chemical processes, the source of F in our system will be NaF, an inexpensive and safe salt, and sugars as the main carbon source. In-depth analysis of all the environmental and economic bene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Eco-aware Persuasive Networked Data Devices for User Engagement in Energy Efficiency'.

assistant: **Innovation**

GreenSoul pursues higher energy efficiency in public buildings by altering the way people use energy consuming shared devices (lights, printers) and personal devices (personal pluggable appliances). For that, it applies a twofold strategy: 1)persuades users to increase their energy-awareness and change their e-consumption habits and 2)embeds intelligence in the devices to let them autonomously decide about their operation mode for energy efficiency purposes. For the first part, it will use a variety of techniques, from persuasive social applications to physical interaction mechanisms linked to the devices. For the second part, it will learn from the usage habits, acting only when an energy wasteful behaviour is detected or the users do not heed the devices’ suggestions. The aim is to add a green-soul to devices in a pluggable manner to avoid costly replacement of equipment and the corresponding disposal of old-fashioned devices to the landfill. GreenSoul’s exploitation potential is addressed towards buildings of public use. There, the persuasion of users is particularly challenging since they hardly perceive the benefits of having eco-friendly behaviour, i.e. they do not pay the electricity bill. GreenSoul will design and develop an integrated ICT platform to: a) improve users awareness of their energy consumption habits; b)study the ecological behaviour of the people in shared environments; c)analyse the effectiveness of different persuasion techniques; d)assist users through a decision-support engine’s recommendations; and e)provide socio-economic evidence about the viability of the changes proposed. GreenSoul aims to prove that combined behavioural and ICT interventions over public buildings result in energy savings which surpass 20%. It will be deployed in five buil