RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Transmission of Financial Shocks: A systemic Input-Output GVAR approach' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Over the past years, the economic and financial systems have become increasingly globalized and vulnerable with important implications for risk management by commercial banks and other institutions. However, despite the fact that sophisticated models for quantifying credit risk have been developed, everyday practice has shown that risk, due to its inherent role in the economic system, is affected by both: (i) macroeconomic factors and (ii) financial factors. Hence, it would be extremely beneficial to generate scenario analyses, real-time simulations and forecasts based on a core set of variables.For instance, a question of great importance is the following: “what is the impact of a sudden change, e.g. collapse of the Greek banking sector, on the financial services sector of another country, e.g. Austria?” Currently, standard models are not capable of addressing such questions, because such questions involve interdependence at the sectoral and country level, simultaneously. It would be helpful to measure how vulnerable specific entities are, to shocks in other related entities of the system. This process would help in redesigning the system so as to be able to absorb shocks. Here, we make the assumption that most phenomena in the global economy are interdependent on each other. In this context, we will estimate - for the first time in the literature - the impact that a shock in a specific entity in a specific country can have on any other entity in any other country. The proposed approach will be based on the GVAR model and on Input-Output Tables for constructing the weight matrix, which is crucial in expressing the aforementioned relationships. To do so, we will make use of network theory to select the dominant entities in the system. Our findings will help develop rele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multi-omics characterization of immune triggers in Moyamoya disease' in the context of a Horizon Europe call.

assistant: **Objectives**

This project aims to characterize a recently discovered link between a rare genetic disorder of the brain, called Moyamoya disease (MMD), and the cellular immune response against microbial infections. MMD is characterized by a progressive occlusion of arteries at the base of the brain leading to stroke. Mutations in Ring Finger Protein 213 (RNF213) represent the most common genetic cause of MMD, however, it is suggested that environmental stimuli are needed to trigger disease onset in genetic carriers. Intriguingly, we recently discovered RNF213 as a novel antibacterial protein that can target intracellular Listeria (Gram+), providing strong protection to Listeria both in vitro and in vivo. Similarly, RNF213 can bind intracellular Salmonella (Gram-), mediating its ubiquitin-dependent degradation. Moreover, we also identified RNF213 as a cellular sensor for proteins modified by ISG15 (ISGylated proteins), a ubiquitin-like modification of the immune system induced by interferon. These observations not only uncover RNF213 as a novel key antimicrobial protein, they also suggest an important role for the immune system in triggering MMD. MULTIMOYA starts from the hypothesis that dysregulated immune responses to infections might trigger MMD disease onset in patients carrying mutations in RNF213. To investigate this hypothesis, we will determine whether MMD patient-derived immune cells respond differently to interferon, LPS or bacterial infection by mapping altered pathways using a multi-omics approach, combining genomics, transcriptomics, proteomics and (tracer) metabolomics data. Results will be validated by biochemical and imaging analysis in relevant patient-derived/like cellular models as well as in mouse models of MMD that we will establish. Together, these experiments wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Super Variable Vector Combnation for Voltage Optmisation Energy Saving Hub' under Horizon 2020.

assistant: **Concept**

SuperEH aims complete and commercialise the SVVC Energy Hub platform that PowerSines has developed during the last years. The Energy saving prototype shows good performance and there are not technical risk in completing the implementation of the project. SVVC is the electrical topology that gathers into a single design several Voltage optimisation techniques. It integrates two patented technologies developed and used by PowerSines: Induced Negative Voltage (INV) and Variable Vector Combination (VVC). The new topology reduces from four transformers into two transformers (3 phase). This architecture is controlled through eight switches commanded from the algorithm running as embedded SW in the uProcesor control board. We integrate all the power and control components into a single box. All the relevant variables of the installation are collected, monitored and controlled remotely. To get full advantage of all the possibilities we are making the Remote EMS: a complete set of SW tools, running on external webservers, allowing the communication with the local Hubs, monitoring and controlling energy, power analytics/decision making for both Administrative and User profiles, etc.) Added value of this combination SVVC Energy Hub + Remote EMS: - Implementation of cost-efficient E-saving solutions. (20%) - Short payback period. 1 to 3 years . - Simple installation, no modification of current electrical infrastructures. - Stabilisation of the system, detection of irregular consumption. - Proprietary automatic energy saving measurement algorithm unique (and patent pending). - Reduction of maintenance costs (40%) and extension of equipment lifetime (30-50%).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Enabling Innovative Space-driven Services for Energy Efficient Buildings and Climate Resilient Cities'.

assistant: **Concept**

BUILDSPACE aims to couple terrestrial data from buildings (collected by IoT platforms, BIM solutions and other) with aerial imaging from drones equipped with thermal cameras and location annotated data from satellite services (i.e., EGNSS and Copernicus) to deliver innovative services for the building and urban stakeholders and support informed decision making towards energy-efficient buildings and climate resilient cities. The platform will allow integration of these heterogeneous data and will offer services at building scale, enabling the generation of high fidelity multi-modal digital twins and at city scale providing decision support services for energy demand prediction, urban heat and urban flood analysis. The services will enable the identification of environmental hotspots that increase pressure to local city ecosystems and raise probability for natural disasters (such as flooding) and will issue alerts and recommendations for action to local governments and regions (such as the support of policies for building renovation in specific vulnerable areas). BUILDSPACE services will be validated and assessed in four European cities with different climate profiles. The digital twin services at building level will be tested during the construction of a new building in Poland, and the city services validating the link to digital twin of buildings will be tested in 3 cities (Piraeus, Riga, Ljubljana) across EU. BUILDSPACE will create a set of replication guidelines and blueprints for the adoption of the proposed applications in building resilient cities at large.


**Keywords:** Digital Twin, BIM, IoT, EGNSS, Copernicus, Blue Green Infrastructure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Skeletal Muscles Antagonize T Cell Exhaustion in Chronic Viral Infections'.

assistant: **Innovation**

Although skeletal muscles are not traditionally considered to be constituents of the immune system, the loss of skeletal muscle mass in chronic infection is frequently associated with impaired T cell function, or T cell exhaustion. Whether and how muscles regulate T cell exhaustion is unknown. We found that skeletal muscles antagonized T cell exhaustion in mice chronically infected with lymphocytic choriomeningitis virus (LCMV) clone 13. Spleen-derived exhausted CD8+ skeletal muscle-infiltrating lymphocytes (SMILEs) formed clusters in muscles where their antiviral function and proliferative potential were restored. These revived CD8+ SMILEs egressed from muscles and migrated back to lymphoid organs to sustain long-term antiviral immunity. We aim to understand how skeletal muscles regulate antiviral CD8+ T cell function, metabolism, and migration.(1) Using metabolomics and RNA-sequencing approaches, we identified 46 metabolites that were enriched in muscle interstitial fluid and two myokine-encoding genes that were upregulated in muscle tissue, respectively. We plan to test whether and how these metabolites and myokines restore the antiviral functions of exhausted CD8+ T cells.(2) We found that the CD8+ T cell migration between the spleen and skeletal muscles was guided by a protein gradient of regulator of G protein signaling 16 (Rgs16). We plan to identify the Rgs16-interacting partners and the molecular mechanisms underlying Rgs16 protein gradient-driven CD8+ T cell migration. (3) We observed that increasing muscle mass using a genetic approach resulted in both increased numbers of CD8+ SMILEs and decreased viral titers in LCMV clone 13 infected mice. We plan to explore the therapeutic potential of increasing muscle mass for enhancing protective T cell responses in ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Architecting Manufacturing Industries and systems for Adaptability' (AMISA) targeting Seventh Framework.

assistant: **Abstract**

Systems provide value through their ability to fulfill stakeholders’ needs. Inevitably, these needs evolve over time and diverge from an original system’s capabilities. Thus, the system must be disposed of or periodically upgraded at substantial cost.The objective of the AMISA project is to develop a generic, quantitative methodology for architecting manufacturing lines, product systems and customer services for optimal adaptability to unforeseen changes in stakeholder needs, technology development, and government regulations. The methodology will be validated in six real-life pilot projects to provide concrete evidence that it is: 1) Generic and tailorable, 2) Scalable, 3) Usable and 4) Cost effective.AMISA will deliver a step-change in the performance of European industry, characterized by a higher reactivity to needs and more economically compatible products and services. Manufacturing systems or products/services designed for adaptability will save 20% either in cost or cycle time and increase their valuable lifespan by 25%. During manufacturing these systems will consume less energy and natural resources and produce less pollution and waste. Adaptable systems will also be more amenable to adjustments in regulatory frameworks (i.e. environmental, health, safety, etc.).The AMISA consortium is composed of four large manufacturers and two SMEs representing the Food, Machinery, Aerospace, Automotive, Communication and Optronics sectors. The consortium also includes four research centers with experience in fusing engineering and economic theories with practical applications in industry and government.Since AMISA deals with systemic issues, its expected impact is vastly wider than just the industries that are directly involved in the project. Accordingly, the project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Examining Arabidopsis floral organ number patterning using a dynamic computer model' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Flowers arise from the flanks of the shoot apical meristem, a mass of undifferentiated stem cells at the tip of the growing plant. Young flower buds become organised into four concentric whorls of tissue that give rise to invariant numbers of sepals, petals, stamens and carpels. Extensive genetic studies have identified several genes with important functions in regulating flower development. It is known that the so-called floral identity genes act first to differentiate the presumptive floral meristem from the cells of the shoot meristem. This is followed by the organ identity genes that function combinatorial to establish the whorls of cells, within which the floral organs then arise.While a lot is known about the events leading up to the establishment of organ identity, much less is understood about the mechanisms used to carve those organs out of each whorl. The goal of this project is to understand the genetic and cellular events that lead to the partitioning of the first two whorls into sepals and petals. To this end, we will use fluorescent reporter genes and live imaging with confocal microscopy to characterise the cellular dynamics and differentiation events in the wildtype meristem. We will use this data to build a dynamic virtual model of the developing meristem.Next we will study changes in cellular behaviour in meristems where development has been experimentally perturbed and compare those data to the wild type. This will provide both a comprehensive understanding of the processes involved in establishing floral architecture as well as a flexible model that can be expanded and customised to the needs of any other group. The project is inter-disciplinary, as it involves biological experimentation as well as mathematical and computer modelling. I t is also soc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Logistics for Energy Crops' Biomass' (LOGISTEC) targeting Seventh Framework.

assistant: **Abstract**

Cost-efficient, environmental-friendly and socially sustainable biomass supply chains are urgently needed to achieve the 2020 targets of the Strategic Energy Technologies-Plan of the European Union, which are likely to be impeded by the potential scarcity of lignocellulosic biomass from agriculture. Innovative techniques for crop management, biomass harvesting and pre-treatment, storage and transport offer a prime avenue to increase biomass supply while keeping costs down and minimizing adverse environmental impacts.The LogistEC project aims at developing new or improved technologies for all steps of the logistics chains, and at assessing their sustainability at supply-area level for small to large-scale bio-based projects. It encompasses all types of lignocellulosic crops: annual and multi-annual crops, perennial grasses, and short-rotation coppice.Through specific meta-analyses, laboratory tests, field trials, ecosystem modelling and mechanical engineering, the project will deliver recommendations for optimal technologies as well as new equipments and systems. A framework will be developed to integrate chain components and assess their sustainability in terms of environmental, economic and social impacts. It will enable a multi-criteria optimization of the supply chains, making the most of the progresses achieved in the new logistics technologies. The optimization system will be developed and tested in a set of bio-energy and bio-materials case-studies across Europe. Improved logistics will be demonstrated at pilot and industrial scales in 2 regions (Eastern France and Southern Spain) for existing bio-energy and bio-materials value chains. All technology developments will be carried out with industrial partners, to speed up their transfer to market. Project results wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'NONLINEAR MAGNETO-OPTICAL kerr EFFECT STUDIES OF THIN MAGNETIC FILMS'.

assistant: **Objectives**

The aim of this network is to organise a coordinated effort between months. Each of them will be focused on the main tasks of their host university and industry partners for the development of the newly discovered Nonlinear Magneto-Optical Kerr Effect (NOMOKE) for magnetic institution, but will also spend several periods at the other partners institutions to get familiar with all aspects of the project. In particular interface studies and the exploration of its potential applicability for magnetic imaging. Magnetic multilayers show exciting new properties like this will include short visits at the laboratories of the industrial partner(s). The total time spend on this activity may vary from one post Giant Magneto Resistance and oscillatory exchange coupling, that have a doc to the other, but will amount to approximately 6 to 12 months total. great potential for practical applications in sensors and for recording. For these systems, the interfaces between the various metallic films play This programme will also benefit from other related EC projects that we are an essential role, but experimentally they are very hard to investigate by involved in, which will increase the possibilities for international exchange of students. standard magnetic probes. We propose to study the properties of magnetic (multilayer) films using the Nonlinear Magneto-Optical Kerr Effect (NOMOKE), which is not only interface specific, but has been shown to lead to Nonlinear Kerr rotations that are three orders of magnitude larger than its linear counterpart. We will also explore the possibilities to use the observed huge Nonlinear Kerr rotations for magnetic imaging. Though at present this will be mostly relevant for laboratory studies, the continuing rapid developments in laser technology may lea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Union Contest for Young Scientists 2005' (ECYS05) under Sixth Framework.

assistant: **Objectives**

Host country of the 17th European Union Contest for Young Scientists is the Russian Federation.Period of maintenance - September, 17-22, 2005. Host organisation responsible for preparation and maintenance of the 17th EU Contest - the Bauman Moscow State Technical University.The Consortium includes:the Bauman Moscow State Technical University and the Russian Youth Engineering Society and the Public Corporation - External Economic Joint Stock Company on Tourism and Investments Intourist""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synthesis of Aquaculture and Marine Ecosystems Interactions' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

During the last decade several EU projects have dealt with the environmental issues of marine aquaculture in Europe and the current knowledge in this field has grown significantly. Most of the results are, however, not readily accessible and an overview and synthesis of the most important environmental issues is virtually lacking. It is therefore difficult to integrate this knowledge into the environmental requirements of the Common Fisheries Policy (CFP).We aim to bring experts from the many aspects of aquaculture-environment interactions together for a discussion of the most significant advances in the knowledge from the existing and on-going research and for a discussion of the future perspectives of marine aquaculture within Europe particularly in the environmental context, and for integration of these advances into the environmental requirements of the CFP. From these discussions a review and synthesis of the obtained results will be presented in a high-impact international journal to bring the consequences of recent advances to more general attention and to provide suggestions for the future EU research agenda.To fulfil these objectives the project will organise a workshop for experts in the field, create a writing group to produce a review and synthesis for high-impact international publication and finally edit a book with contributions from experts in the field.