RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated control of polysaccharide and lignin biosynthesis to improve cellulose content, availabity and fibre quality' (COPOL).

assistant: **Innovation**

The proposal complies with the Common Agricultural Policy in the diversification of Agriculture in the area of non-food and forage crops. It will lead to wealth creating-opportunities that are environmentally desirable in a number of developing industrial fields. It is designed as a core discovery programme using polemics and leading to gene isolation involved in the biosynthesis of cell wall lignin's and hemicelluloses in the model species tobacco. The influence of these components on fibre properties and cellulose availability will be determined in modified plants to define the limits to which they can be manipulated beneficially. These deliverables can be used to direct molecular breeding programmes and genetic modification to improve fibre and will be extended to the commercial species, poplar, for biomass energy and improved pulping and paper making, maize, for improved forage digestibility and flax for improved production of industrial fibre.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Proof of Concept of Model-based Cardiovascular Prediction'.

assistant: **Objectives**

CARDIOPROOF is a proof-of-concept project that consolidates the outcomes of previous VPH projects and checks the applicability and effectiveness of available predictive modelling and simulation tools, validating them in interrelated clinical trials conducted in three European centres of excellence in cardiac treatment (from Germany, Italy and the UK). CARDIOPROOF focuses on patients with aortic valve disease and aortic coarctation, which, if left untreated, can ensue irreversible heart failure. As a result treatment becomes mandatory, but optimum timing and the best type of treatment still remain difficult to determine. With more than 50.000 interventions per year within the EU, the diseases addressed by CARDIOPROOF have a significant socio-economic impact. Present clinical guidelines are highly complex and rely mostly on imaging diagnostics and clinical parameters, without benefiting, as yet, from patient-specific disease modelling based prediction. CARDIOPROOF goes beyond the current state of the art by conducting validation trials aimed at covering and comparing the complete spectrum of cardiovascular treatment, predicting the evolution of the disease and the immediate and mid-term outcome of treatment. Operational clustering is going to provide a seamless clinical solution that applies different modeling methods to realize the potential of personalised medicine taking into account user-friendliness as a key component of clinical usability. CARDIOPROOF's goal is to provide first-hand data on comparative cost-effectiveness and clinical efficacy of the most advanced VPH approaches compared to conventional diagnostics and treatment algorithms, thus accelerating the deployment of VPH methods in clinical environments, and bring to maturity holistic patient-specific comput
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Thermodynamics of Quantum Transport' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Electronic components are shrinking and finally reaching the scale of single molecules; promising novel applications to sensors, photovoltaics, heating and electronics. As these components get smaller, important and new physical phenomena impose limitations on how these devices can operate. Quantum mechanics and non-equilibrium thermodynamical fluctuations dominate, challenging all the conventional engineering tools accepted in electronics. The objective of this proposal is to use the novel tools from quantum non-equilibrium thermodynamics to understand the effects of fluctuations in transport in such devices. Average quantities that were good to characterize and control devices in the classical scale become inadequate, as the fluctuations of single trajectories of particles become very large. Although much work has been done to understand quantum thermodynamics, many questions are open regarding its impact on transport on molecular devices.The objective we propose will be addressed by research focused on overcoming the following challenges: (i) Understand the effect of quantum coherence as a thermodynamic potential in molecular devices. (ii) Apply the Open Quantum Systems TD-DFT functional to model transport in molecular devices (iii) Develop a consistent method to characterize transport devices with large quantum fluctuationsEach of these rely on existing theoretical techniques, but they have not been used together for the proposed purpose before.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Identifying subtype specific networks involved in sensory representation in mouse primary visual cortex'.

assistant: **Objectives**

To produce relevant behaviors, the brain integrates and processes sensory information. Neurons in the primary visual cortex extract sensory information by responding preferentially to certain visual features. This feature preference, or tuning, is thought to arise from structured connections established between cortical neurons. Accordingly, it was found that connected neurons in the cerebral cortex share similar tuning properties. Interestingly, the neurons populating the cerebral cortex correspond to numerous neuronal subpopulations, involved in different functions. However, the functional involvement of this large neuronal diversity in cortical computation has been so far studied for a few broad neuronal subpopulations, leaving the fine subpopulations mainly unexplored. Do these poorly studied neuronal subpopulations share similar tuning properties? Is the structured connectivity giving rise to tuning subpopulation specific? I will use a new technique referred as in situ transcriptomics to study the tuning properties and locomotor modulation of the diverse neuronal subpopulations in the mouse primary visual cortex. This technique provides high throughput identification of neuronal subpopulations on fixed tissue based on the transcriptomic signature of neurons. I will thus determine the identity of in vivo recorded neurons a posteriori and decipher the relationships between cell identity and responses to visual stimuli. Combining this approach with single cell initiated monosynaptic tracing, I will then explore the link between subpopulation specific connectivity and tuning properties. This project will greatly contribute to the understanding of how cortical neuronal subpopulations interact to encode sensory information. I will perform these experiments in the Cortica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Carbon And Nitrogen cycling In Forest ecosystems' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

To study the transformations of carbon and nitrogen through the atmosphere-plant-soil-groundwater system. This includes experiments using 15N as marker. To quantify the abilities of species of different trophic levels (plants, fungi, soil animals, microbes) to use and to store different forms of C and N, and to investigate the efficiency of these assimilation processes and their contribution to open and closed biogeochemical cycles (ecosystems function and biodiversity). To integrate and to model ecosystem fluxes of carbon and nitrogen, and to make predictions on the effect of atmospheric deposition, of climate and land-use changes on biogeochemical cycles in forests.The project considers also aspects of land-use changes (coniferous vs. deciduous forest & comparisons with  grassland) along a transect form Northern Sweden to Central Italy and from the Ore Mountains to the Vogues.  The CANIF project anticipates  -in general: Comparison of deciduous (Fagus) and coniferous (Picea, Pinus) forests including old fertiliser trials, natural resource gradients, and controlled conditions (root windows, laboratory).  -in trees: Above and belowground growth, C and N metabolism and allocation, organic and inorganic N-uptake (natural dl5N-values & 15N-labelling. Identifying C/N imbalanees (stareh & amino acids). Role of ground cover in C and N fluxes.  -in mycorrhizae: Biodiversity of Picea- and Faqus -ectomycorrhizae, species specific C/N interaction with roots, N assimilation and transport of organic and inorganic N by mycorrhizal species.  -in soil fauna: Assessment of functional groups, soil animal contribution to decomposition, interaction with soil microorganisms.  -in soil microorganisms: Ammonification, nitrification and denitrification, gross and net mineralisation, bacterial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rethinking Affective Game Epistemologies (RAGE): Investigating how knowledge is produced and put to use in affective gaming' (RAGE) targeting Horizon Europe.

assistant: **Abstract**

Affective gaming - or gameplay that is influenced by a player's emotional state - is a research domain at the intersection of HCI and affective computing; yet the field has stagnated over the years since its inception back in the early 1980s. In RAGE, I will revitalize the field of affective gaming by addressing foundational epistemic problems that are contributing to this stagnation. RAGEs research objectives tackle explicating unclear and hidden assumptions and value sets in this space, and the practical tensions that exist in terms of implementation. I analyze the field through both a theoretical lens in the first year, and moving to a practical implementation of affective games in the second. In this project, I will transfer my knowledge in designing and creating affective games for the implementation aspects of RAGE while Prof. Elisa Mekler (ITU Copenhagen, Denmark) will support the theory aspects. With this fundamentally interdisciplinary project, I will collaborate with and connect many research groups and labs at ITU from different disciplines, including the Center for Digital Play, the Affective Interactions and Relations (AIR) lab, and the Interaction design (IxD) lab. Collaboration within this interdisciplinary team and broadening my research portfolio to include theoretical and critical research will allow me to shape a research vision and establish myself as a key researcher of affective gaming within the EU, in service of my eventual goal to lead my own research group within the EU.


**Keywords:** Affective Gaming, Emotion, HCI, Theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Creation of an automatic paint machine with color graduation anc qixing possibilities for the automobile repair industry' in the context of a Fourth Framework call.

assistant: **Objectives**

Actually all automotive professionals know that repainting is a very demanding business with more than 500.000 colour references in the world. These colours must be matched with the greatest possible precision using paints with a wide range of characteristics ( solvents, lacquers,priming
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strategies for Organic and Low-input Integrated Breeding And Management', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

SOLIBAM will develop specific and novel breeding approaches integrated with management practices to improve the performance, quality, sustainability and stability of crops adapted to organic and low-input systems, in their diversity in Europe and taking into account small-scale farms in Africa. SOLIBAM will: 1. Identify traits specific for adaptation to low-input/organic conditions over a wide range of agro-climatic conditions in Europe 2. Develop efficient phenotyping, genotyping and molecular tools to monitor heritable variation during selection. Molecular analysis of functional polymorphisms will increase accuracy in breeding methodologies and improve monitoring of genetic diversity and adaptation along generations. It will also increase the understanding of adaptive phenomena 3. Develop the use of within-crop diversity to stabilise yield and quality in the face of current and increasing variation in organic and low-input agriculture 4. Design, develop and test innovative arable and vegetable cropping systems based on integration of a high level of diversification in crop management with the use of genetically diverse populations or varieties 5. Compare the effectiveness of different breeding strategies under conventional, low input and certified organic farming to set up optimal strategies for the production of varieties suitable for organic and low input farming taking into account the traits which are avoided in conventional breeding 6. Develop methodologies for farmers’ participatory research that exploit SOLIBAM's advances in low-input and organic farming 7. Quantify the effects and interactions of breeding and management innovations on crop nutritional, organoleptic and end-use quality 8. Evaluate socio-economic and environmental impacts of SOLIBAM breeding and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Large-scale identification of secondary metabolites, metabolic pathways and their genes in the model tree poplar'.

assistant: **Concept**

Poplar is an important woody biomass crop and at the same time the model of choice for molecular research in trees. Although there is steady progress in resolving the functions of unknown genes, the identities of most secondary metabolites in poplar remain unknown. The lack of metabolite identities in experimental systems is a true gap in information content, and impedes obtaining deep insight into the complex biology of living systems. The main reason is that metabolites are difficult to purify because of their low abundance, hindering their structural characterization and the discovery of their biosynthetic pathways. In this project, we will use CSPP, an innovative method recently developed in my lab, to systematically predict the structures of metabolites along with their biosynthetic pathways in poplar wood, bark and leaves. This CSPP method is based on a combination of metabolomics and informatics. In a next step, the CSPP tool will be combined with two complementary genetic approaches based on re-sequence data from 750 poplar trees to identify the genes encoding the enzymes in the predicted pathways. Genome Wide Association Studies (GWAS) will be made to identify SNPs in the genes involved in the metabolic conversions. Subsequently, rare defective alleles will be identified for these genes in the sequenced population. Genes identified by both approaches will then be further studied either by crossing natural poplars that are heterozygous for the defective alleles, or by CRISPR/Cas9-based gene editing in poplar. The functional studies will be further underpinned by enzyme assays. Given our scarce knowledge on the structure of most secondary metabolites and their metabolic pathways in poplar, this large-scale identification effort will lay the foundation for systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Cardiotoxicity High-throughput screening (HTS) with zebrafish embryo'.

assistant: **Innovation**

The complex nature of pharmaceutical new molecules generation, both in terms of R&D process and regulatory requirements, indicates a huge need for innovative tools/services for optimal delivery to patients of novel medicines in the fastest and cheapest manner. The pharmaceutical industry strives continuously to produce new, safer and more efficacious drugs for unmet needs, evolving different synthesis techniques, expanding numbers of leads for potential drug candidates. However, this abundance has also created a new set of challenges in efficient processing of drug libraries for target validation and toxicity assessment. High-throughput screening (HTS) is thought to be key in handling this flow of new potential therapeutics in a systematic and time-efficient manner. But, there is a strong evidence that in vitro cell-based assays and subsequent preclinical in vivo studies do not yet provide sufficient pharmacological and toxicity data or reliable predictive capacity for understanding drug candidate performance in vivo. The model developed by ZeClinics with specific focus on cell and molecular interactions and physiological parameters improves this situation and helps to determine the corresponding responses to bioactive agents.The aim of ZeCardio project is to use zebrafish model to develop HTS of large libraries in live organism for cardiotoxicity assessment. Our complete system analyses the impact of drugs and diseases in heart performance (Heart rate, Arrytmia, AV Blockage and Ejection fraction) and the performance of the vascular system (Blood flow and vasodilatation/constriction).


**Keywords:** Cardiotoxicity, High-throughput screening (HTS), in vivo models, preclinical screening, zebrafish, drug withdraws
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SOLARSHARC - A DURABLE SELF-CLEAN COATING FOR SOLAR PANELS TO IMPROVE PV ENERGY GENERATION EFFICIENCY' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Dirt on solar panels causes losses of more than €40bn p.a. and over 100Mtonnes of CO2 emission. Cleaning is expensive (up to €100/m2 depending on accessibility) and wastes water. Current self-cleaning coatings suffer from short lifetime (2-3 years), poor transparency, and high cost (over €20/m2). They are usually not cost-effective, are not widely used, and losses are accepted as part of the operation of the plant. The objective of this action is to bring to market a new product, SolarSharc, which will provide, for the first time, a transparent, durable, cost-effective and permanent self-cleaning solution for solar panels. This patented coating technology uses multi-functionalised silica nano-particles bonded strongly to the coating polymer matrix to provide a highly transparent, low cost, durable and robust self-cleaning coating. Target markets are utility scale solar and the rapidly growing (18% CAGR €26bn by 2022) Building Integrated Photovoltaics (BIPV) markets. The objectives of this 24 month action are to commercialise the SolarSharc coating and new self-cleaning BIPV modules from the current TRL6 prototype to operational demonstration (TRL9) in BIPV, certification, commercialisation and supply chain measures to deliver rapid growth. The action will be delivered by a consortium of SMEs (Opus, Onyx, Millidyne) representing the supply chain from materials to application together with specialist coatings technologists from London South Bank University and solar testing expertise from CEA. We are requesting a grant of €2.78m to bring SolarSharc to market, securing €2m of post-action financing for sales growth. Commercialisation of SolarSharc will develop new revenues for the consortium of €71m with profits of €45m cumulative over 5 years of sales, creating 243 new job