RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring the Cosmos with the Vera Rubin Observatory' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The standard model of cosmology postulates ingredients that are not present in the standard model of particle physics – dark matter, dark energy, and a primordial origin for cosmic structure. Their physical nature remains a mystery. In the past few years, it has become clear that formidable modelling and data analysis challenges stand in the way of establishing how these ingredients fit into fundamental physics. Starting in 2023, we have an opportunity to uncover the physical underpinning of the cosmological model, using a new window on the universe opened by the Vera C. Rubin Observatory’s Legacy Survey of Space and Time (LSST). Just in its first year, LSST will see more of the universe than all previous surveys combined. By repeatedly mapping huge sky areas, it will create the first motion picture of our universe. The resulting catalogues will contain billions of galaxies and other, more exotic objects such as the electromagnetic counterparts of gravitational wave sources.This project aims to turn these catalogues into physical insight by solving three pressing challenges: (1) the formidable computational expense of accurately modelling this complex data; (2) the need to tease out subtle signals from (possibly unknown) systematics; (3) capturing the rich information in the “cosmic web” of galaxies tracing the large-scale structure of the universe, inaccessible by standard analysis methods. I will achieve these aims through a unique approach, combining innovative data emulation techniques to accelerate forward-modelling, a ground-breaking ‘explainable artificial intelligence’ approach to scientific discovery, and advanced hierarchical Bayesian methods to achieve not just precision (small error-bars) but accuracy (unbiased results). The combination of the unique tools I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A PRECISION MEDICINE TRIAL LEVERAGING BLOOD-BASED TUMOR GENOMICS TO OPTIMIZE TREATMENT IN OPERABLE STAGE III AND HIGH-RISK STAGE II COLON CANCER PATIENTS - THE SAGITTARIUS TRIAL' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

SAGITTARIUS aim to optimize the clinical management of locoregional stage II high-risk/stage III colon cancer (LRCC). Approximately half of all LRCC patients relapse within two years from time of curative surgery because of imaging-undetectable micro-metastatic residual disease (MMRD). Given the lack of reliable predictors of individual risk, LRCC patients are treated with a one-fits-all adjuvant chemotherapy. This gunshot approach results in either over- or under-treatment. Measuring circulating tumor DNA (ctDNA) in the patients’ bloodstream can diagnose MMRD. Retrospective studies show that ctDNA detection after surgery predicts cancer recurrence with high sensitivity and specificity. SAGITTARIUS will deploy a ctDNA assay to detect the absence, presence, or persistence of MMRD in individual patients. The diagnosis of MMRD will guide and personalize therapeutic interventions. SAGITTARIUS is a pragmatic trial whereby real-world patients are treated in two parallel trials based on their MMRD status and the genomic landscape of their tumors.  ctDNA positive patients are randomized to conventional or personalized targeted therapy. ctDNA negative patients are randomized to a physician-driven therapy or a Wait&See strategy. The efficacy and effectiveness of this potentially ground-breaking new strategy of care will be measured via multiple outcomes, including safety and time to events variables,  patient-reported outcome measures, and health-economics evaluation. Since colon cancer deaths are usually associated with metastases rather than local disease, MMRD will also reclassify how this disease is perceived by clinicians. This new prism will allow for treatment to be better matched against the tumor biology, also allowing for better monitoring – via ctDNA – to assess diseas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advancing Sustainable In Situ Remediation for Contaminated Land and Groundwater' under Seventh Framework.

assistant: **Concept**

This project will develop innovative in situ remediation concepts for the sustainable management of contaminated land and groundwater, as required by the WFD. The proposal has 18 academic and industry partners, with expertise in groundwater remediation issues, ranging from pore-scale processes to field-scale application, as well as technology development, water management/treatment, regulation and policy. The research links lab-scale studies of processes with field-scale evaluation and demonstration of novel technology applications, using state-of-the-art methods. It will develop new scientific understanding, performance assessment tools and decision-making frameworks which advance the use of sustainable in situ remediation for contaminated land and groundwater. The network is support by comprehensive knowledge transfer activities. The aim is for more sustainable treatment, to optimise resource investment in environmental restoration, considering technical, social and economic factors. The network will create a comprehensive training environment for early career scientists and engineers in this field. Each academic institution, in cooperation with the industry partners, is well positioned to support the training and professional development of fellows, through existing research training packages and new activities proposed herein. In addition to formal graduate-level instruction and directed research, an innovative package of training initiatives is offered. These include workshops, summer schools, web-based sharing of research and key outputs across the network, complementary training at partner institutions, practical work secondments with industry partners, and participation at national and international conferences. Graduating fellows will benefit from interdiscipli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transport, retention, and release of synthesized DNAs through microplastics affected-soils: mimicking bacteria behavior with regards to climate change and global warming' (TRAMPAS) targeting Horizon 2020.

assistant: **Abstract**

Microplastic pollution has received considerable attention for the marine environment, but hidden out of sight are microplastics in soil.  In Europe alone, there are likely more microplastics in soil than in all the world’s oceans. Microplastics can adversely affect soils, but the underlying mechanisms and wider impacts are poorly understood. A significant impact could be increased hydrophobicity of the soil pore surface, which can increase the movement of potentially pathogenic microorganisms. I found that the concentration of microplastics and soil temperature increase the soil-water contact angle, a measure of hydrophobicity. This project will explore how microplastics influence soil through the development of hydrophobicity and the impacts to bacteria and virus transport and retention. It builds on my recent research that was the first to link the development of soil hydrophobicity with increased leaching of bacteria. Two challenges of societal importance are addressed: (1) microplastic pollution and (2) pathogen fate in the environment.I will bring together a range of approaches, starting first with quantifying how climatic stresses and soil properties interact with microplastics to induce hydrophobicity. This will be followed by leaching experiments, where microbial retention and leaching will be tracked with a novel approach using synthesised DNA. Soil pore scale processes will be measured using microfluidics, where the spread and retention of microbes and water can be visualised directly under highly controlled conditions. Finally, I will study microplastic contaminated soil, exploring the formation of microbial colonised microplastics – the ‘plastisphere’.Working with a strong multidisciplinary team I will gain excellent training in state-of-the-art analysis ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Machine Learning for Structural Health Monitoring of Cultural Heritage' (MLCULT).

assistant: **Innovation**

Europe is home to about 400 UNESCO world heritage sites and has a growing tourism industry employing many people directly and indirectly. Hence, it is of concern to ensure the cultural heritage (CH) buildings are inspected properly and correct damage diagnosis is performed. Incorrect damage diagnosis will lead to loss of cultural value and may lead to the closing of the monument, thus affecting society in general and the livelihood of people associated with it. The proposed MLCULT project is motivated by the need to perform damage diagnosis of CH using image-based machine learning (ML) techniques, thus helping to preserve them. The popularity of ML approaches and deep learning algorithms has increased considerably over the last two decades. Computer-vision-based damage detection employing convolutional neural networks will be integrated with laser scan data, nondestructive testing, and other condition assessment data to provide a better estimate of existing areas of damage. The model will be trained from the database of earthquake-damaged CH collected by the host institutions UMinho and Polimi. Several typologies of damage indicators will be identified and quantified, due to weathering, moisture ingress, algae growth, and efflorescence. The project will be supervised by Prof. Loureno at the University of Minho, Portugal, who is an international expert on CH, and Prof. Luigi Barazzetti at Politecnico di Milano, Italy whose has expertise in computer-vision, drone and image-based damage detection. Finally, a prototype inspection system (first of its kind in CH field) using drones-based real-time damage detection will be demonstrated, specifically for CH damage pathologies.  The proposed method can help in identifying structural anomalies in CH that must be urgently repaire
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INterfacing CArbon-based NAnomaterials to neurons: toward new horizons in cellular NEuroProsthetics', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Neuroengineering is a growing area of Neurosciences, aimed at repairing, replacing and enhancing the function of damaged neuronal tissue. However, devices designed to interface the Central Nervous System (CNS) faces substantial clinical challenges, resulting from the CNS unique anatomy and physiology. Today, exciting perspectives are represented by reconstructive/repairing strategies, providing a functional bridge through the damaged tissue and restoring functions via implantable assisting devices.Lately, C-based nanomaterials, such as Carbon Nanotubes (CNTs) and Nanocrystalline Diamond (NCD) thin-films raised a lot of interest as the most promising materials in the building of nanoelectrodes and substrates for cell growth. Among their well-known properties (thermal, chemical, electrical), their in vivo stability and biocompatibility were explored and demonstrated.This project aims at studying the interactions occurring between these C-based nanomaterials and neurons, focusing on a significant step forward in the domain of neuroprosthetic materials, ultimately relevant to cognitive and regeneration/repair applications.The study of biological, electrophysiological and biophysical processes occurring at the interface between nanomaterials and neuronal systems is in fact intended to provide a solid foundation for generating novel biochips and cellular-level neuroprosthetic devices, ultimately designed to help repair damaged CNS tissues, and to build novel brain-machine interfaces. Such a research domain of Neurosciences, at the overlap between nanotechnology, physics and neurobiology, is not only offering today new exciting opportunities for better healthcare and nano-biotechnological applications, but it is also aimed to advance our basic understanding of the (dys)functio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of poly (ADP-ribose) polymerase and oxidative stress in cardiovascular complications of HIV infection' (ADP-ribose).

assistant: **Concept**

Recent research has lead to an increase in knowledge of the HIV virus and its mechanism of invading cells, which has lead to the development of effective therapies to retard the progression of the disease. This success has meant that HIV patients are livi ng longer and have become the fastest-growing cardiovascular disease population in the world. An understanding of the mechanisms involved and therapies for these HIV-induced cardiovascular problems are urgently required. This proposal examines the role o f oxidative stress and poly (ADP-ribose) activation in HIV envelope-protein mediated endothelial cell (EC) dysfunction. It determines whether therapies, developed to combat such activation, will be suitable for HIV-mediated cardiovascular disease. Specific ally, the aims of this project are (1) to investigate the effect of the HIV envelope proteins TAT and GP120 on vasorelaxation of ex vivo rat aortic rings in response to acetylcholine. Using specific inhibitors of oxidative stress, superoxide dismutase mime tics, and the PARP-specific enzyme inhibitor PJ-34, we will determine the extent of involvement of these pathways in vasculature dysfunction induced by HIV proteins. (2) We will also perform studies on isolated endothelial cells treated with HIV proteins t o determine specific cellular effects mediated by oxidative stress and PARP activation. The cellular effects to be investigated include viability, energetic status and expression of pro-inflammatory mediators. (3) We will use tissue from novel transgenic animals, including the PARP and NF-?ß knockout mouse, to further study the signalling pathways and possible intervention points in cardiovascular cells affected by HIV proteins. In conclusion, the data obtained from this proposal will greatly advance the knowledg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Associated Vasculitis European Randomised Trials' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The purpose is to improve the treatment of a group of rare, multisystem diseases defined below in order to save lives and improve the quality of life for survivors. Four RCTs will test new therapeutic approaches aiming at: - improving disease control with intravenous immunoglobulin or sulfamethoxazole/ trimethoprim in addition to standard treatment.- Lowering cyclophosphamide toxicity by replacing continuous oral treatment with pulsed intravenous administration- reducing relapse rate by elimination of nasal carriage of Staphylococcus aureus - reducing relapse rate by long-term, low dose azathioprine treatment in place of treatment withdrawal.Anti-neutrophil cytoplasm autoantibody (ANCA)-associated systemic vasculitis (MSV) is a group of severe, multisystem, autoimmune diseases (e. g. Wegener's granulomatosis and microscopic polyangiitis), which cause marked incapacity and chronic morbidity due to irreversible organ damage, such as renal failure. The incidence of AASV is increasing, especially in the elderly, and exceeds 25/million/year. Care outside specialist centres is often fragmented and treatment suboptimal. The toxicity of current treatments contributes to incapacity through high cumulative exposure to steroid and cytotoxic drugs. This concerted action will improve the efficacy of treatment, reduce disease-induced damage and minimise drug toxicity by testing frontline theories on improvement of therapy based on recent concepts on pathogenesis.The four RCTs described above will utilise innovative statistical techniques and trial methodology. Prognostic markers and surrogate end-points will be defined to optimise clinical decision making by identifying patient subgroups and will contribute to the design of a further series of RCTs to test new drugs currently in pilo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of an innovative automated and wireless trap with warning and monitoring modules for integrated management of the Mediterranean (Ceratitis Capitata) & Olive (Dacus oleae) fruit flies', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The e-FlyWatch project addresses a major problem faced by Fruit, Vegetable & Olive (FVO) grower SMEs throughout Europe; a problem acknowledged in numerous scientific studies and in many official EU reports. In particular, the project aims in the development of a novel monitoring system for managing & controlling the population of two of the world’s most destructive fruit pests: the Mediterranean fruit fly (Ceratitis capitata, medfly) and the Olive fruit fly (Bactrocera oleae Rossi - formerly Dacus oleae). The apparent benefits from the use of the e-FlyWatch system are the reduction of the resulting damages in FVO production, as well as the sustainable use of insecticide agents. The above targets will be met with the development of e-FlyWatch system, which will include a novel autonomous and wireless trap and a Local Station that will receive data from the traps, and analyze them using integrated optical recognition software. Processed data will be (a) sent to end user via SMS, providing basic information like warnings, reporting, etc (b) transmitted to a Central Station, providing statistical information, density maps, prediction models, etc. The e-FlyWatch system will allow a) producers to immediately take action and minimize crop damages & b) advanced users, authorities, researchers, to evaluate control methods and pesticides effectiveness. This proposal offers an advanced Integrated Pest Management Solution for medfly and dacus and addresses all the great challenges faced by the SMEs in this sector, thus offering an attractive market opportunity for the participating SMEs that offer such products and services to the FVO growers. The consortium includes interested SME partners through the whole supply chain of the sector with international sales networks, as well as r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Process integration of biogas and fuelcell technology via simulation of the gas purification process (PROBAT)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Due to the complex question of the biogas cleaning system we look for two postgraduate students: The first one's objectives are centered on the modelling /simulation of the biological H2S cleaning process. At the beginning it is necessary to observe the most important parameters to attain a continuous series of data. Therefore he shall carry out an experimental study of H2S removal in the bio trickling filter. On the basis of the experimental data a correlation of the input trace gaze concentrations to the resulting output concentrations will beamed. He will use the results of the laboratory tests for training a neural network. In parallel to that he will develop the simulation model, which is based on the Modelica Simulation language. For the validation of the simulation model, data from the EU project EFFECTIVE can be used. Through coupling of the neuronal net with Modelica it can be tested, if the neural net used the right algorithm. The second postgraduate student should develop a simulation tool for a comprehensive Biogas Cleaning Unit. Based on the results of the experiments of the other fellow and laboratory tests, made in the EU project AMONCO, the model will be developed. The aim is here, to simulate the coupling of different cleaning methods (chemical , physical and biological) to a comprehensive and cost effective Biogas Cleaning Unit . Again the Modelica simulation language should be used, but of course other simulation tools might be taken into consideration.