RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Deep Earth Elastic Properties and Effective Rheology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The interface between the Earth’s rocky mantle and molten outer core, located 2900 km below the surface, is marked by a patchwork of enigmatic structures. These structures, revealed by anomalous reductions in the speed of traveling seismic waves, are characterized by high density, partial melting, and low topographic heights (10-40 km above the core-mantle boundary). Due to the low seismic wave speeds, they are called UltraLow Velocity Zones (ULVZs). Since their ﬁrst discovery in the 90s, our understanding of the ULVZs has been based on seismic observations. The inﬂuence of microscale distribution of melt and minerals on the seismic signature and the internal structure of the ULVZs remain a challenging question in geophysics. To address this question, this project will use a cross-scale approach to quantify the inﬂuence of partial melting and solid composition on the elastic properties and rheology of the UL-VZs based on a microstructural model. Using the microscale constraints on the physical properties, the km-scale internal structure of the ULVZs will be simulated using a ﬁnite elements model.The interdisciplinary approach of this project relies on using state-of-the-art high performance computational ﬂuid mechanics models to answer fundamental questions in Earth Sciences. The uniqueness of this approach arises from the special consideration of microstructures, a crucial, but difﬁcult to quantify aspect in Earth sciences. The multidisciplinary aspect of this work will train the researcher in new modeling skills. Upon his return to India, where research in deep Earth is still in its infancy, the researcher will be able to establish his own research agenda leading the country’s effort in that area. Continued inter-national collaboration between the host institution and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'p73 dependence in cancer: from molecular mechanisms to therapeutic targeting' (P73CANCER) targeting Seventh Framework.

assistant: **Abstract**

p73 is a transcription factor of the p53 tumor suppressor family. In approximately 50% of all cancer patientsthe tumor suppressor function of p53 is irreversibly disabled by point mutations, which makes p53 one of themost frequently mutated genes in cancer. This is entirely different for p73 and much of my previous work inthis field has been devoted to research on the role of p73 in cancer.In sharp contrast to p53, p73 is often highly expressed in its wild-type form in solid tumors compared tothe surrounding normal tissue. This suggests the rather challenging hypothesis that p73 has oncogenicfunctions in cancer cells, which promote tumor progression and therapy resistance. This concept is supportedby clinical data demonstrating p73 overexpression to be correlated with advanced tumor stage, metastasis,therapy resistance and poor overall survival in multiple tumor entities including the ‘major killers’: breast,lung and colorectal cancer. When p73 is depleted from cancer cell lines, tumor cell proliferation andtumorigenicity are reduced, indicating that tumor cells with high p73 expression are p73-dependent. Thisplaces p73 in line with oncogenes like Myc or mutant Ras, which are similarly essential for the tumorigenicphenotype. However, tumor cells are not only addicted to a particular oncogene but in many cases codependenton other cellular factors - a phenomenon termed ‘non-oncogene addiction’. Since p73 also hastumor suppressive functions, p73-dependent tumor cells are likely to be critically dependent on cooperatingfactors, which keep the proapoptotic and tumor suppressive functions of p73 in check. Inhibition of thesefactors would be ‘synthetically lethal’ with overexpression of p73. From a clinical point-of-view it would beextremely valuable, if we knew these factors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '13th International Symposium on Microsomes and drug oxidations' (1998-2002).

assistant: **Innovation**

The next International Symposium on Microsomes and Drug Oxidations (MDO) will take place in Stresa-Lake Maggiore, Italy, from the 10th to the 14th July of the year 2000. This Symposium, the 13th in the series of MDO Symposia, which are held biannually on the same topic, represents the major international meeting in the field of drug oxidations and deals with genetic and environmental factors which affect in man both the therapeutic efficacy of drugs and the adverse reactions caused by drugs and other exogenous chemical agents. Approximately 700 delegates are expected to attend from the majority of the European Countries and also from the United States, Australia, Canada and Japan. Some of the most important scientists in the field have agreed to participate. The scientific programme will cover the most important advances in the biophysics, genetics and molecular biology of the drug metabolising enzymes. However the major emphasis of the conference will be on the applications of biotechnology and on clinical and toxicological implications of drug metabolism.These are areas in which there have been very considerable advances in the last few years, with results of great theoretical interest, and also of great relevance to both clinical practice and Pharmaceutical Industry. The topic of the conference is therefore most timely with its multidisciplinary content it will be of great interest to the wider scientific Community and it will also offer contributions with considerable practical implications. The purpose of this application is to secure EC funds to facilitate the participation of young European Scientists, particularly those who have produced good work, but lack the financial resources to present their results at MDO 2000. The prime criterium for selection will be sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advancing knowldge for Long-term Benefits and climate Adaptation ThRough hOlistic climate Services and nature-based Solutions' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Increasing vulnerability due to climate change requires cross-sectoral management of the territories with bottom-up approaches based on active community participation. Climate change intensifies territorial risk and impacts severely on human migration and displacement, particularly in sub-Saharan Africa. Avoiding maladaptation associated to internal migration as well as to other adaptation actions which do not adopt a nexus approach (e.g. water-food-energy nexus) requires effective planning and management of migration hot spots. At the same time, it calls for more integrated strategies which simultaneously support sustainable development growth pathways and climate resilience development in the African context. ALBATROSS aims at addressing these challenges by delivering novel, innovative and decision making-relevant tools and knowledge which will support the adoption of feasible, effective, and sustainable need-based adaptation strategies into AF policies and programs. It will do that by co-creating climate services and tools which will enable the weighting of compound and cascading impacts (benefits and threats) on ecosystem health, food security, socio-economic vulnerability while addressing specific natural hazards (e.g., drought or flood) or sectoral climate adaptation needs (e.g., agriculture) through nature-based solutions (NBS) and other climate adaptation measures. The methodological approach of ALBATROSS will be tested ad validated in different Sub-Saharan countries, leading to the co-creation and co-evaluation with key stakeholders of need-based adaptions options and plans. By combining participatory approaches with fundamental research grounded on the latest generation of observational data and modelling techniques, ALBATROSS will provide robust and science-b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Extended Home Environment for Robust seamless interconnection between netwOrks'.

assistant: **Concept**

e-HERO aims to research, develop and validate an advanced affordable, symmetric, point-to-point broadband radio access network, for private and professional use within the Extended Home Environment. The system will provide two-ways bit rates of 10 and 100 Mbps (Fast Ethernet) from the Central Office to the multi-dwelling residential building at a target price of 10 KEuro per data link. The system will utilise advanced technology and architectures, for efficient and flexible usage of spectrum resources to provide a cost-effective system (in Euro/bit). A complementary innovative home network (WLAN) based on Hiperlan/2 standard at speed of up to 100 Mbps will be developed within this project that allows to control the Quality of Service for the end-user.Objectives:The main objective of the e-HERO project is to research and develop an advanced affordable, symmetric, point-to-point broadband radio access networks to the Extended Home Environment. The system will provide two-ways bit rates of 10 and 100Mbps (Fast Ethernet) from the Central Office to the multi-dwelling residential building at a target price of 10KEuro per data link. e-HERO will serve as a platform for integration of broadband applications and interactive services for multiple home networks. In order to offer a comprehensive solution to the end-user, a home networking sub-system based on next-generation 100 Mbps HiperLAN/2 Wireless Local Area Network will be developed. This complementary home network will distribute the data inside the home and will have provisions that allow controlling the Quality of Service (QoS) for the end-user.Work description:The work is divided into 10 distinctly defined WP.In the first stage, user requirements will be gathered and the specifications will be identified for the entire sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cloning and sequencing of the cdna coding for two golgi autoantigens ; functional analysis by site-directed mutagenesis', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The first objective of the work will be the cDNA cloning of the genes encoding two autoantigens specific for the Golgi complex, p210 and p230, by immunological screening of two cDNA expression libraries. The sequence of these clones will be analysed in order to characterize the structure, to understand the function of the proteins and to know wether they are included in a new family of proteins associated to the Golgi apparatus that are preferent targets in certain autoimmune diseases. Fragments of the proteins will be subcloned into a bacterial expression vector in order to overproduce the peptides and to obtain antibodies against p210 and p230. Finally, clones encoding wild type or mutants p210 or p230 will be transfected into eucaryotic cells in order to study the domains involved in the localization and interactions of these proteins in the cell.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Making Biological Minds' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The ER (Dr Sean Dyde) is a promising early career researcher, having obtained his PhD in 2014 and published 5 articles in top-tier journals and respected edited collections, whose main focus to date has been the history of the biomedical sciences.The PI (Professor Gregory Radick), has published extensively across the history of the human sciences, has experience leading national and international projects, and has engaged in many public engagement activities.The host institution (Leeds) is an internationally renowned centre of research with strengths in the history and philosophy of science.The project's overall objective is to use state of the art research in the history and philosophy of science to reposition current debates over the role of the neurosciences in defining human nature, by placing the relations between the sciences and the humanities into historical perspective. This project builds upon the ER's established research expertise in the history of the biomedical sciences, but with the support of the PI and the host institution, the scope of his work will be extended into the history of the humanities.The ER's 5-10 year career aim is to expand his areas of expertise into the history of the British human sciences and the history of German philosophy and medicine. This project maps a path to achieve this by connecting his existing expertise in the history of the biomedical sciences with the history of the humanities and the reception of German philosophical ideas into Britain during the nineteenth century. Europe remains a world-leader for research into the history and philosophy of science, and this project will allow the ER to progress in his academic career and consolidate links between English- and German-speaking scholars. Work produced by the project wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Energy COnversion in ENGINES (ECO-ENGINES)' (ECO-ENGINES) under Sixth Framework.

assistant: **Objectives**

The objective of the ECO-Engines proposal for a NoE is to set-up a Virtual Research Centre (VRC) on advanced engine combustion modes for road transport, with special emphasis on the use of alternative and renewable fuels, and to establish it as a world reference in the domain. The VRC will structure the excellence of European research on all aspects of new generations of high efficiency, low CO2 and noise, near zero emission engine combustion processes like CAI, HCCI or CCS, and other emerging high potential techniques. This will contribute to the EC objective of developing and promoting future generations of more environmental friendly powertrains and vehicle concepts for road transport, using cleaner and renewable energy sources. Addressed topics are experimental techniques (including optical diagnostics and ultra low emission measurement), combustion simulation, fuel/engine couples testing and evaluation and engine related aspects and combustion control. The VRC will result from integrating major actors' activities in the field in Europe, with the aim of durability beyond the end of EC funding. Work will lay the basis for the VRC to centrally and jointly manage knowledge, resources and research actions: set-up of a central database, internal communication via an internal web site, development of standard methodologies and procedures, exchanges of personnel, and the definition of new common high potential research actions. Emphasis will be put on the dissemination of knowledge and exploitation of results. The major action in this sense will be the set-up of a common integrated education and training programme towards students, researchers and engineers all over Europe. Other actions to spread excellence include: creation of an ECO-Engines public web site, communicatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Environmental impacts of invasive alien species in aquaculture' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The project is a CA designed to support the draft EC regulation 'Rules governing the introduction of exotic species and on containment of stock in aquaculture' (FISH A3/RB/2004025-A3). IMPASSE responds directly to Task 12, priority area 8.1. B.1.3. Its goal is to develop: Guidelines for environmentally sound practices for introductions and translocations in aquaculture, guidelines on quarantine procedures, and risk assessment protocols and procedures for assessing the potential impacts of invasive alien species in aquaculture. The project mobilises a consortium of experts in the management of aquatic alien species, including persons who drafted the ICES and EIFAC Codes of Practice on Introductions and Transfers of Aquatic Organisms, and key contributors in complimentary EC projects.The project is organised into six work packages: WP1 Review of scientific information on alien species for aquaculture; WP2 Analysis of the impacts of alien species on aquatic ecosystems; WP3 Risk assessment and modelling; WP4 Dev elopment of guidelines; WP5 Consultation and dissemination; WP6 Scientific coordination and project management. The main activities require considerable collation and interrogation of existing information, development of strategic guidelines and protocols, and wide consultation and dissemination.IMPASSE will produce a review of knowledge, develop methods and protocols to assess the environmental and economic risks of species introductions, stimulate exchange of scientific knowledge and opinion, and develop guidelines for environmentally sound practices for introductions and translocations in aquaculture. This will provide the information necessary for managers and policy makers to develop policy, legislation and measures to mitigate adverse impacts, both at European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Come to your Senses!' (SENSE09) targeting Seventh Framework.

assistant: **Abstract**

SENSES09 will be a sensational event with large appeal, widespread impact and creative science. Located at the majestic Isarpost location in central Munich, Germany this event will attract 300 – 500 guests and through a strong awareness program will attract artists, scientists and the general public alike. The night has three main initiatives: To improve the communication between science and the public; To improve the image of the scientist; To encourage scientists and artists to collaborate. Using the five senses as our theme will provide a broad array of scientific topics with a universal appeal to the curious human. On the evening of September 25th from 20:00 to 2:00 we will invite our guests to enter our sensory enhancing environment and experience sense themed science, art, performances and live DJ’s. Overall, this event will help to improve the image of Europe as a fantastic place to due research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Researchers’ night 2007 of the West part of France : Researchers and ICT' (ATLANTIC), addressing dissemination and exploitation.

assistant: **Impact**

For the Researchers’ Night 2007, 8 partners in 5 towns of the West part of France (from Bordeaux to Brest) will share their human and scientific richness. Researchers working in universities, research centers as Inserm and scientific, technical and industrial culture centres will be at the core of the events during the evening of the 28th of September 2007, around the theme Researchers and the Information and Communication Technologies. Music and theatre events, offered by researchers themselves, will demonstrate that they are not these “unreachable” persons but in fact people like any other. Meetings with researchers in unusual places will demonstrate that they are accessible, have hobbies, families, help the citizen’s daily life, have a fascinating job. Workshops and night visit of scientific as well as cultural sites will welcome the public. Viewings, discussions and debates will allow anyone to express himself about the image of researchers and their role in our society.  In order to make the young public more sensible to the world of the researchers, a drawing competition (Please draw a researcher) will be launched, during the awareness campaign and will be addressed to fundamental, secondary and High artistic schools. In order to illustrate the European participation in the project and allow the large public to better understand the European support in favour of researchers, the European dimension will be pointed out at different stages of the project with the “drawing competition” (awarded at a European level) and with a European stand, which will be set up around informative and promotion functions. Beneficiaries local researchers of European support will be especially involved during the night. A common graphic design will be created during a general assembly o