RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Controlled release drug delivery systems' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The expertise in the rational design of nano-particles, mesoporous structures, hydro-gels, degradable polymers, aerogels, ceramics etc with variable bulk and surface chemical compositions and physicochemical properties has reached a climax but their potential use in the biotechnology industry has yet to be fully explored.The detoxification of blood using enzymes and antibodies immobilised onto mesoporous materials (in a bioreactor specifically designed for this purpose) is one of the goals of this proposal, e.g. heparinase I, immobilised on periodic mesoporous organosilanes, to remove heparin from the blood.The second is the use of nanomaterials, (degradable polymers, mesoporous supports and nanoparticles), in controlled release drug delivery systems. Many drugs, which are highly successful in selectively targeting diseases in a test tube, fail in clinical applications due to obstacles created by stability, delivery and potency in the body.For example, RNA interference is a developing alternative treatment for many diseases but RNAi will not survive in the bloodstream and so the design and synthesis of a suitable delivery vehicle (degradable polymer to encapsulate and protect the RNA molecule) is essential if this treatment is to have future applications.The world leading research group in controlled release drug delivery is at MIT and the aim of the researcher is to spend 2 years working with a range of experts in materials synthesis and drug release and capture under different conditions.She would return to the MSSI, a materials institute in Ireland, whose ethos is the development of interdisciplinary skills for practical applications, to set up bioreactors for the detoxification of blood and initiate controlled release drug delivery studies using mesoporous materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Modelling nanoparticle toxicity: principles, methods, novel approaches'.

assistant: **Concept**

ModNanoTox will develop a number of well-documented and technically advanced models describing the behaviour of engineered nanoparticles in organisms and the environment. Background to these models will be a thoroughly documented database, constructed based on: (1) an advanced evaluation of physicochemical properties of nanoparticles and in silico modelling of their reactivity; and (2) assessment of the characterisation methodologies as well as toxicity protocols used to develop biological responses in toxicological studies. At the next level whole datasets will be evaluated for internal consistency and then compared with other relevant sets. The evaluation stage will be followed by development of toxicity models based at the individual organism level, using statistical and mechanistic models, in parallel with models predicting environmental fate. The toxicity and fate models will be integrated in mechanistic models to predict the long term risks of engineered nanoparticles for populations under realistic environmental conditions. The risk assessment models will be developed in close collaboration with appropriate stakeholders and end users to ensure their suitability for practical use in relevant legislative contexts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Network for co-ordination of policies and programmes on e-infrastructures' under Seventh Framework.

assistant: **Concept**

A new ERA-NET is proposed to further the integration of national, EC and global e-infrastructure programmes. An experienced consortium comprising relevant national programme managers is proposed to develop the ERA-NET, called e-InfraNet. The partners know well the existing policy initiatives and identify a gap in the uptake and integration of innovative policy at national and EC level.A sustainable ERA-NET will be established which will build on existing initiatives and develop a long term approach to the point of implementing joint programmes and calls. A structure is setup to prioritise a sequence of focus areas for collaboration through initial scoping workshops, development of action plans and implementation of initial or pilot joint activities. E-InfraNet aims to engage with programme managers outside the initial consortium and disseminate results widely to this key target group globally. Dissemination and networking activities are built into every stage of the workprogramme.A key long-term impact will be the more efficient use of resources, and the adoption of best-practice in national e-infrastructure programmes. E-InfraNet will lead to a convergence of funding programmes and avoid unnecessary overlap. The variable geometry approach will allow for progress to be made, while giving flexibility to adjust to national requirements and leave the route open to all to build on successful joint actions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Jupiter after Galileo and Cassini' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The past decade has produced a very extended and high quality new data set about the Jovian system, including observations of the planet's atmosphere, the surfaces and interior structure of the four large satellites, the magnetic, plasma and dust environments, and the rings. As a result of this data set, our understanding of the Jovian system and of the Jovian type planets in general has been significantly improved as compared to the view provided by the Voyager missions in the 1980's.The Galileo mission, consisting of an orbiter and an atmospheric entry probe, has been making important discoveries at Jupiter during its continuing exploration of the Jovian system begun in December of 1995 and expected to end in 2002. The Cassini/Huygens mission to Saturn, through performing a gravity assisted flyby at Jupiter, returned a unique data set, as this spacecraft, the Galileo orbiter and Earth-based science teams (operating ground-based and Earth-orbit instrumentation) performed simultaneous observations. The full exploitation of the entire Jupiter data set will go on for decades.Starting in late 2004, the Cassini/Huygens mission will perform a 4 year long monitoring of the Saturnian system. The amount of information to be returned is expected to exceed the Jupiter data set by several orders of magnitude.The main objective of the proposed meeting is to update all the results and cutting edge research activities concerning both the Jovian and the Saturnian system, throughout all relevant planetary science disciplines.Furthermore, the new vision of the Jovian system (its present state as defined by observations, currently ongoing processes and the interaction between the different elements of the system), and the lessons learned from the Galileo mission, will be used as a fresh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Deciphering immune evasion mechanisms of metastatic cancer cells using CRISPRa-inducible reporters'.

assistant: **Innovation**

Most cancer patients are resistant to immunotherapies, especially patients with liver and bone metastases. This suggests that during metastasis, cells acquire additional immune evasion mechanisms that dictate susceptibility to immunotherapies. Current immunotherapies initiate T cell-mediated killing of cancer cells. However, combining them with agents that target other immune cells in the body, such as natural killer (NK) cells, may be more effective. Whether immune evasion mechanisms of metastatic cells differ between organs and whether these mechanisms can be targeted to improve immunotherapeutic strategies remains unknown. The first aim of this proposal is to leverage a molecular barcoding technique named CaTCH (CRISPRa tracing of clones in heterogenous cell populations) to search for new mechanisms of NK cell immune evasion. CaTCH enables tracing metastatic cancer cells in vivo and isolating clones in a barcode-specific manner for subsequent characterization and functional experiments. We engineered a human non-small-cell lung cancer model with a complex CaTCH barcoding library. Subsequently, we injected the cells into mice harboring NK cells and mice having no NK cells in an experimental metastasis assay. We identified several barcoded clones enriched in specific organs under immune pressure. I aim to investigate this dataset to find novel mechanisms of NK cell immune evasion in the metastatic environment. In the second aim, I will combine molecular barcoding with replicative history tracing of cells to identify cancer clones that evade immune-mediated dormancy in the metastatic niche. I will compare the transcriptional and molecular profiles of dividing cells high in abundance to dividing cells low in abundance to find novel mediators of immune-mediated dormancy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Generation of Inter-neuron deficient mouse model' (INTERMMOODEL) under Sixth Framework.

assistant: **Objectives**

The neural circuits underlying the formation of functional networks in the cerebral cortex constitute one of the most complex physical systems in the World. Much of this complexity arises during development through the interaction of two distinct neuronal types, glutamatergic projection neurons and aminobutyric containing (GABAergic) interneurons.Recently, interneuron dysfunction has been associated with severe neurological and psychiatric disorders (e.g. epilepsy, schizophrenia and bipolar disorder). In order to achieve true progress in the understanding of cortical development and of neurological diseases associated with cortical dysfunction, a complete account of the development of its neuronal constituents is essential.In that sense, despite the detailed picture that is emerging about the development of cortical projection neurons, the mechanisms underlying the development of interneurons in the cerebral cortex have remained poorly defined. The general goal of this project is to obtain a comprehensive definition of the cellular and molecular mechanisms controlling the development of cortical interneurons.To reach this aim, I propose to take a multidisciplinary approach by combining mouse genetics, novel genomic applications, cutting-edge imaging techniques, and conventional cellular and molecular biology methodologies. In addition, I will develop new genetic tools to engineer developmental models of cortical disorders involving interneuron deficiency.Thus, successful execution of the project will result in:i) New knowledge of the mechanisms underlying the specification, migration and differentiation of cortical interneurons, andii) Generation of new developmental models of cortical disorders resulting from interneuron deficiency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Intelligent manufacturing of advanced tailored coatings deposited on low cost materials for highly demanding tribological applications' in the context of a Fourth Framework call.

assistant: **Objectives**

The surface modification of materials is widely used in present-day manufacturing to convert low cost materials into valuable engineering materials. The surface modification processes that are currently used range from low cost processes like electroplating used for mass production (electrogalvanized steels) to high cost processes like physical vapour deposition introduced over the last two decades (e.g. ceramic coatings like TiN on steel-based cutting tools). Standard electrolytic and electroless plating from aqueous solutions allow the deposition of pure metals, alloys, and composite coatings. The addition of metallic, ceramic or polymeric micronsized particles to these plating baths allows the production of composite coatings with superior mechanical and tribological properties at a fraction of the cost of chemical and physical vapour deposition techniques. This explains the success of these coatings in industry for systems like Ni-SiC in automotive industry, Ni-Co-Cr203 in jet engines, and Ni-PTFE as low friction coatings. The upcoming availability of nanosized particles (range 2 to 50 nanometers) and the ability to tailor their surface chemistry, e.g., by a plasma treatment at a reasonable cost or by proprietary surfactants, will allow the electrolytic and electroless production of coatings that have improved and even new properties. The use of nanosized particles enhances the synergy between particle and matrix while the particles and cathode and thus increases the degree of codeposition. In this research proposal, a plasma treatment enhances the particle pull-out force resulting in a higher bond strength between consortium of 6 industrial companies will combine their efforts to demonstrate the feasibility of depositing composite coatings containing nanosized part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coordination Action for Reinforcing the Health National Contact  Points Network' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The Framework Programme is the European Commission instrument put into place to finance research in Europe. As part of the Community Research and Technological Development Policy, it is expected that participation in the Seventh Framework Programme will increase and the quality of submitted proposals must rise. The objective of this project is to reinforce the network of National Contact Points (NCPs) for the health related research areas and the Health theme under the Seventh Framework Programme by promoting trans-national cooperation. This trans-national cooperation is extended to officially appointed Contact Points in International Cooperation Partner Countries, and other third countries Contact Points are not excluded.  The basis for improving the NCP services in the area of health across Europe will be to identify the weaknesses of the network. The action will focus on identifying and sharing good practices. The mechanisms put in place will be benchmarking, training programme and networking and brokerage events. A set of execution, result and impact indicators will measure progress and efficacy of these mechanisms. (And corrective action will be taken if needed). The network will assist NCP and potential applicants to adapt to the new health issues in the Seventh Framework Programme. Special attention will be given to helping less experienced NCPs rapidly acquire the knowledge accumulated in other countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'A new method for the objective measurement of the quality of seafoods'.

assistant: **Objectives**

There exists no satisfactory physical method for the objective measurement of the quality of seafood products. So concluded the project AIR3 CT94 2283. This proposal concerns a completely new physical method for seafood quality measurement. It arises from observations made in FAIR project CT97 3020. It is proposed to carry this work further with determination of quality as the main objective. The quality factors to be studied will be:1. post catching/slaughter deterioration of fresh fish,2. changes due to frozen storage and to multiple freezing,3. correlation with organoleptic variables, texture, and other quantifiable quality related variables. Prototype instruments will be built for validation in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Marie curie training site on neuronal signals and development' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Knowledge on developmental control processes in the brain has to be combined with expertise in Cellular & Molecular Neurobiology in order to understand degenerative processes or to achieve restoration of function in the brain. Excellent training in both fields will be offered.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Modular Platform for Controlled Ion Beam Generation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Countless sophisticated macroscopic products rely on innovative materials with unique features, designed with nanoscale precision. To harness the variety of functionalities provided by biomolecules and other complex molecular species as the key ingredient for the design of prospective advanced nanosystems and materials, a current technological gap must be closed: the lack of a universal method capable to handle fragile molecules under vacuum conditions without compromising their integrity. With the present project we aim to introduce a versatile and powerful platform based on innovative methodological advances to overcome this obstacle. The envisioned technology is designated CIB (controlled ion beam) and will allow the generation of ultrapure ion beams from any solvable substance in a fully controlled manner using a cost-effective, marketable setup. The novel instrumentation capitalizes on achievements within the ERC project 'MolArt' and will be suitable for highly sophisticated deposition processes for nanofabrication and nanotechnology, while furnishing at the same time a general module integrable in analytical mass spectrometry (MS/ Proteomics). SoftBeam, the prototype instrument to be accomplished within this PoC project is our pilot application where CIB is firstly realized and validated. With this technology an entire new class of sensitive substances can be routinely processed in a size-selective manner. Boosted flux intensities reduce processing time and fully controllable energy of the molecules results in a highly increased reproducibility, cleanliness and homogeneity of molecular beams generated. The modular platform is adaptable to various disciplines and has the potential to become a standard tool in the nanotechnology and analytical (bio)chemistry communi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dissecting the role of Translational Regulation in Tumorigenesis' under Horizon 2020.

assistant: **Concept**

The control of translation is a key determinant of protein abundance, which in turn defines cellular states. The impact of translational regulation may be even greater during the transition from homeostasis to malignancy, as revealed by the surprisingly low correlations between mRNA and protein levels in human cancer databases. This raises the intriguing possibility that through an ability to generate aberrant downstream networks of translational regulators, oncogenic drivers might impose altered protein synthesis programs that become the driving force for tumor formation and malignant progression. We recently unveiled a hitherto unappreciated role for upstream open reading frame (uORF) translation in tumorigenesis and unearthed a novel switch from conventional EIF2 initiation factor-mediated to alternative EIF2A-mediated uORF translation. These observations suggest that uORFs constitute an exciting new frontier in the field of translational regulation with the potential to fundamentally impact cellular fate. Here, I propose to systematically analyze the function of uORFs during tumorigenesis. First, we will conduct an in vivo CRISPR/CAS9-based screen in mice to elucidate the role of thousands of uORFs in development, differentiation and upon oncogenic transformation. Second, focusing on select uORFs surfacing in the screen, we will document their role during tumor initiation and progression. Third, we will develop novel tools to detect uORF translation in vivo, exploit them to monitor uORF translation during different stages of tumorigenesis, gain mechanistic insight into their function and finally test the relevance of these findings in human cancer. Collectively, these approaches will provide unprecedented and comprehensive insight into the function of uORFs, unravel