RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Chemistry of Sponge Microbiomes' (COSMos) under Horizon 2020.

assistant: **Objectives**

Molecules made by nature, or natural products, inspire the majority of currently approved small molecules for use in medicine. With an increase in widespread antibiotic resistance and the perpetual search for anticancer drugs, new sources of natural products must be discovered. The marine environment is a proven, prolific source of novel bioactive molecules and much of the ocean remains chemically and genetically unexplored. The mesophotic zone is particularly neglected because of the technological difficulty of reaching this twilight zone of the ocean. Shallow water marine sponges have been well documented to have diverse microbial populations and impressive chemical repertoires. Mesophotic sponges, however, are relatively unstudied in terms of their natural product potential. This project aims to take a deep dive into the metagenomes of mesophotic sponges for their natural product potential. Hybrid sequencing and assembly of metagenomes of eight prioritized sponges will uncover new biosynthetic gene clusters for heterologous expression and chemical elucidation. This study will combine large data analyses, cutting edge molecular and synthetic biology approaches and bioinformatic techniques to survey the natural product potential of mesophotic sponges and discover new molecules with medicinal potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'EERA SEcretariat' in the context of a Seventh Framework call.

assistant: **Objectives**

Ten leading European Research Institutes have taken up the challenge to found a European Energy Research Alliance (EERA). The key objective of the EERA is to accelerate the development of new energy technologies by conceiving and implementing Joint Research Programmes in support of the Strategic Energy Technology (SET) plan by pooling and integrating activities and resources, combining national and Community sources of funding and maximising complementarities and synergies. The EERA aims to strengthen, expand and optimise EU energy research capabilities through the sharing of world-class national facilities in Europe and the joint realisation of pan-EU programmes. The primary focus of the EERA will be on the strategic and targeted development of next generations of energy technologies drawing on results from fundamental research and maturing technologies to the point where it can be embedded in industry driven research. In this field the EERA Secretariat is composed by five national research institutes which are part of the ten leading members. They are recognised as being among the leading exemplars of RTO programmes in Europe. All five can be considered as key player in their own country. The high level of experience of the members will conduct to an efficient work done by the secretariat. This work team will be present at every level of the governance and will organise, coordinate and monitor the work of EERA. The scope for significant joint work by the EERA Secretariat includes support to all other players in the EERA and outside through administrative, organizational and communication activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'TICAL: 4D total absorptionTime Imaging CALorimeter'.

assistant: **Objectives**

This 4-year project proposes a breakthrough in particle detectors by developing a highly granular calorimeter with high-resolution timing information, thus providing precise information of the space-time development of electromagnetic and hadronic showers.The objective of this project is to develop a completely new imaging calorimeter that uses light encoding methods, and thus simultaneously records:- the total energy deposited in the calorimeter cells with a time tag in the 10 picosecond (ps) range;- the high-precision spatial distribution of the energy deposition in the calorimetric volume both for low energy (photo-electric and Compton) and high energy (shower components);- the time structure of the signals corresponding to the different components of the shower.The key point in this novel approach is to introduce light production, collection and detection techniques that are now accessible due to spectacular technological advancements in this field, in which the PI is directly involved.  Examples are:- new crystal production technologies (micro-pulling-down (μ-PD,) ceramics, nano-crystals);- photonic crystals, plasmonic resonances and nano-optics;- single-photon-counting silicon photomultipliers, both digital(d-SiPM) and analogue (a-SiPM).The use of precise time information in the tens of picosecond range in calorimetric techniques will have a large impact on different applications in many domains:- High Energy Physic (HEP), in particular at new high energy and high collision rate colliders;- Medical imaging in Time of Flight Positron Emission Tomography (TOF-PET);- Spectrometry of low energy γ- quanta;- Homeland security: crystals of higher sensitivity always be in demand;- Space applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cause-effect relationships of key pollutants on the European rivers biodiversity' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The overall objective of KEYBIOEFFECTS is to provide new generations of scientists with the skills needed to assess the effects of pollution on European Rivers' biodiversity.  The scientific objective of this project is to provide a better understanding of t he causes of ecological quality loss and the cause-effect relationships of pollution and to derive from this knowledge practical tools for water quality assessment.  The development of complementary tools is crucial to achieving this objective: the identification of key toxicants, the quantification of the influence of environmental conditions on toxicant bioavailability, the assessment of these effects at the organism, on populations, on communities and ecosystems, and testing in micro- and mesocosms will result in the description of cause-effect relationships and allow the modelling of toxicant effects on the biota. This RTN will achieve the training and scientific objectives as well as the Transfer of Knowledge to end-users by providing training in the required competences and abilities to early-stage researchers (ESR) and by the participation of water agencies and SME in research, training and the elaboration of case-oriented guidelines for assessing pollution effects in European Rivers". The trainees will achieve the required competences by training through research in different institutions, in courses covering the basis of fundamental and applied research issues and by a practicum in a water agency or an enterprise involved in water pollution assessment. For each ESR, a senior researcher will assume the role of a tutor responsible for a clear definition of the working plan, for the supervision of training through research activities and the coordination of the ESR mobility plan. Twelve [12] PhD projects and f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Anion Exchange Membrane Water stack based on Earth Abundant 2D Materials for Green Hydrogen Production'.

assistant: **Objectives**

The baseline technology for green H2 production is the water-electrolysis (WE). However, roughly 96% of the H2 produced today is from fossil fuels, with the remaining 4% produced through water electrolysis , due to the still-high costs, and lower performance of current electrolysers compared with other production processes not affected by the use of toxic or critical raw materials (CRM). Therefore, there is a need of boosting the development of highly active and efficient catalysts to turn green hydrogen into a viable solution to decarbonise different sectors and to meet the ambitious goals settled in the Hydrogen Strategy.This project proposes an advanced Anion Exchange Membrane Water Electrolyser (AEMWE) stack as a critical milestone to translate the highly promising results coming from the ground-breaking research conducted during the ERC-StG awarded to Dr G. Abellán, into a marketable innovation. The AEMWE stack novelty relies on non-toxic CRM-free breakthrough novel electrodes (anodes) made of two-dimensional (2D) nickel-iron layered double hydroxide materials (2D NiFe-LDHs) that have shown an outstanding catalytic behaviour. Using this electrocatalytic material will allow overcoming the main challenges of WE to produce green H2.The activities to be undertaken under the 2D4H2 project, are aimed to prepare the translation of the 2D NiFe-LDHs electrocatalytic materials into an AEMWE stack as a precursor of a future fully operational 0.5kW electrolyser. For this purpose, the necessary optimisation and characterisation of the electrocatalyst to enable the testing and validation in a pilot plant of the single unit cell, and the AEMWE stack prototype, will be carried out together with the elaboration of an integrated strategy for effectively managing the knowledge genera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Thermal energy storage solUtions to optimally Manage BuildingS and Unlock their grid balancing and flexibility Potential' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

THUMBS UP aims to develop and demonstrate thermal energy storage (TES) at daily (based on environmental friendly PCM) and weekly level (based on TCM sorption technology) solutions to be easily integrated in EU buildings (both connected and not-connected to DHN) to increase their energy efficiency as well as to exploit Power-to-Heat (PtH) approaches also to make EU Buildings as grid flexibility actors. THUMBS UP wants to overcome all the limits of state-of-the-art building-integrated PCM and TCM TES technologies, increasing TES energy density and reducing CAPEX. THUMBS UP innovates at different levels, from modelling to materials and enhance heat exchanger solutions, targeting demonstration at TRL 7. High-performance TES solutions part of an EU sustainable economy is a factor at the core of THUMBS UP. The project develops truly i) bio-based PCMs from raw materials currently wasted in the EU food industry, turning them into valuable TES materials and ii) TCMs relying exclusively on non-hazardous materials and on water as working fluid.  THUMBS UP TES will be demonstrated in 3 demosites (a single-family building in Spain and 2 multi-family buildings in Sweden/Spain) in different EU climates and energy market contexts also to assess THUMBS UP replication potential in two replication sites (ITA, NL). Via its demonstration and replication campaign, THUMBS UP promotes TES role as key enabling technology to optimize thermal comfort and energy efficiency in buildings as well as to promote PtH as facilitator of RES grid integration in a sector coupling approach, to be studied via innovative modelling tools. THUMBS UP gives specific attention to how to fully integrate TES solutions into buildings and wider smart energy networks by combining the technology advancements with TES-tai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'STRENGTHENING CAPACITIES AND PROMOTING INNOVATION IN PLANTOMICS AT THE UNIVERSITY OF SFAX' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Global climate change is seriously threatening food security. Globally, agriculture must find alternatives for chemical fertilisers that contribute significantly to greenhouse gas emissions- and pesticides. Advanced plant breeding and biotechnology tools offer great opportunities to devise sustainable solutions for future farming.Next-generation sequencing technologies has created new research and innovation potential in genomics and transcriptomics. Also, groundbreaking proteomics, metabolomics and phenomics methods now generate big data beneficial to plant biotechnology and sustainable agriculture. In Tunisia, the Research and Innovation systems are not yet sufficiently developed to fully seize the opportunities made by the availability of omics tools to participate in the necessary transition to a sustainable and climate-neutral agriculture. At the University of Sfax (USF), the lack of strong scientific knowledge in plant omics technologies among researchers and of tailor-made plant technology platforms are major constraints to the development of sustainable and resilient agro-systems. The objective of INPLANTOMICS is to foster scientific excellence and innovation at the USF for the future implementation of the first North African plant biotechnological platform promoting sustainable agriculture and healthy nutrition, at the light of a strong European network and partnership. Equipped with the most advanced omics technologies this platform will greatly improve the transfer of knowledge and innovation to researchers and stakeholders including farmers, breeders, nurserymen and agri-food producers.


**Keywords:** Genomics, transcriptomics, proteomics, sustainable agriculture, phytopathogens, drought, platforms, crop biotechnology, food security, healthy nutrition, resi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Construction of a mouse model of g6pd deficiency' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The clinical problem. Glucose-6-phosphate dehydrogenase (G6PD) deficien is the most prevelant human enzymopathy. In its common form it is associated with an acute haemolytic anaemia which may be life threatening, particularily in children. It is also a major cause of neonatal jaundice, which in severe cases can lead to permenant neurological damage.The high frequencies are due to deficient alleles conferring a selective advantage against malaria infection by an unknown mechanism and reach 10% or more in parts of Southern Europe (Greece, Southern Italy). Rarely, G6PD deficiency is the cause of chronic nonspherocytic haemolytic anaemia, which may result in a life-long transfusion requirement.  The overall objectives. The objectives of the present proposal are to gain a better understanding of the molecular pathology of G6PD deficiency by creating an animal model in which a complete study of the molecular disfunctions ocurring in blood, bone marrow and other organs can be assessed. Additionally, this work has clear long term implications for gene therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification of host-factors restricting Salmonella Typhi' under Horizon 2020.

assistant: **Concept**

Typhoid fever is a life-threatening systemic infection that continues to be a serious global health concern, claiming the lives of over 200,000 patients every year. It is caused by the intracellular bacterium Salmonella Typhi, a human-adapted pathogen unable to infect species others than humans. The molecular mechanisms underlying S. Typhi infection are only partially understood. Spanò and Galán recently discovered an antimicrobial pathway that is required to restrict the growth of S. Typhi macrophages derived from mouse (a non-susceptible host) and contributes to S. Typhi host-restriction. Despite this finding, the exact mechanisms used by macrophages to kill S. Typhi as well as the role of these mechanisms in the adaptation to the human host remain unknown. Through this project, I will investigate the mechanisms used by non-permissive hosts to eliminate S. Typhi. I will combine my strong background in molecular microbiology with the world-renowned expertise of S. Typhi-host interactions of the receiving group to identify host genes required to kill S. Typhi. I will apply state-of-the-art technologies, including pooled shRNA screens coupled to next-generation sequencing and the novel and powerful CRISPR/Cas9 technology, supported by a network of local and international collaborators. Specifically, I will: 1) identify Rab GTPases required for S. Typhi killing, 2) identify novel factors involved in pathogen killing through an unbiased genome-wide screen, and 3) elucidate the role of well-characterized antimicrobial factors in the Rab32-dependent killing of S. Typhi. The results will reveal new strategies of host-defence and will extend our knowledge of the host immunity mechanisms controlling the growth of intracellular pathogens. They have the potential to identify new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Mega-evolutionary dynamics of anurans'.

assistant: **Objectives**

Adaptive radiation has been pointed out as the main force responsible for phenotypic and taxonomic diversity. Rapid phenotypic evolution and expansion in the morphospace tend to cease as new niches are occupied, and this early burst pattern has been called mega-evolution. The mega-evolution hypothesis explains the diversification patterns of many but not all clades, and the early evolution of some lineages, such as that of anurans, remains obscure. In MEGAN, I will test the mega-evolution hypothesis for anuran diversification based on larval morphology. This proposal comprises three work packages that reflect the main research objectives:1) To determine how larval characters are distributed in the anuran tree of life; 2) To reconstruct the phylomorphospace of anuran larvae; 3) To determine the rates of diversification of anurans based on larval characters. Taxonomic sampling is designed to cover the entire phylogenetic, phenotypic, and ecological diversity of anuran larvae. Transformation series will be individualized from all larval phenotypic systems and characters will be optimized in a time-calibrated; optimizations will be used to reconstruct the phylomorphospace and to estimate evolutionary rates in all branches. MEGAN is aligned with the Horizon 2020 FAIR data management and Open Science, and thus, both data and results will be publicly available. Moreover, I will disseminate and communicate the results of MEGAN in freely accessible medias and scientific events. With MEGAN, I intend to gain new skills that will substantially augment my qualification and enable me to reach a higher level in my career and to perform excellence-level research.


**Keywords:** tadpole,  morphological disparity,  morphospace,  phylopmorphospace,  evolutionary rates,  phenotypes,  char
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DRUG-ELUTING ELECTRICAL IMPLANT TO REPAIR THE SPINAL CORD' (DREIMS) targeting Horizon Europe.

assistant: **Abstract**

In Neurofibres (FET-PROACTIVE, 2017-2021), we accomplished a major therapeutic advance for spinal cord injury (SCI) by combining biomaterials, pharmaceuticals, and electrical stimulation into an innovative implant able to promote the closure of the spinal cord gap, with axonal regrowth and glial cell migration across large lesions in rodent and porcine models of SCI. In brief, the implant comprised biofunctionalized, conducting polymer-coated carbon microfibres (MFs) that promoted aligned neural cell growth across the lesion, embedded within a drug-eluting hydrogel that filled the tissue defect and reduced fibrosis. These intraspinal elements were complemented with electrodes that provided biphasic electrical stimulation (ES) to the lesion and the perilesional tissue, thus inducing extensive neural regeneration.Building on the initial proof of concept achieved in Neurofibres (TRL 3), DREIMS will mature this novel healthcare technology through TRLs 4-5, becoming close to its approval for use in human therapeutics while creating a business plan to support further exploitation steps. The inventors of the implant filled a patent application (P202230626) on the mentioned results and recently created a spin-off company (Spinal Cord Technologies, SCT S.L.) to pursue the refinement and validation of a successful clinical and commercial medical product. DREIMS builds on those results to consolidate the first-in-class drug-eluting electrical implant to repair the spinal cord. The implant will refine and integrate three modules, namely the microfiber/drug-eluting gel bundles (MIBs) from FUHNPAIIN / SCT S.L. (Spain), spinal electrode arrays (SEAs) from ALU-FR/IMTEK (Germany), and a fully implantable electric pulse generator (IPG) from NEURINNOV (France), thus forming a procedure pa