RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Logistics of Popular Uprisings' (LOOPS).

assistant: **Concept**

Imagine you protest the slide of your country into an autocratic regime. The weather is freezing and you rally in these conditions for weeks. Not a pleasant idea, yet in 2004 thousands of Ukrainians demonstrated against electoral fraud and established a permanent protest camp in Kyiv. For two months, thousands of protesters were in this urban camp, requiring food, toilet facilities and accommodations to regain warmth. And not only in Ukraine, but all over the world, people protest under difficult conditions and have to overcome logistical and personal challenges to pursue their goals. While the literature on social movements and revolution has engaged extensively with popular uprisings and large-scale protests, the logistics that are required for these protests to succeed under autocracy are hardly ever addressed. Existing research has long neglected the fundamental questions that LOOPS engages with. Such as: what logistical activity can be observed during these protests, their quantity and professionalism? Who organizes the portable toilets, provides soup, and blankets? And what effect has the level of professionalism on the legitimacy of the protest and autocratic stability? We will first develop a concept of professionalism in backstage logistics and a theoretical argument about its effect on the legitimacy and course of protests. With this we will create a unique dataset of the logistics during uprisings based on the analysis of images, a new and exciting way to generate data. With a substantive human coding effort, LOOPS will identify the basic logistics, their type, quantity, and professionalism. In a second step, LOOPS will include case studies to gather more information about financial and organizational sources for protest logistics.  Third, we will test the im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Accurate Seasonal Forecasts for Boosting Renewable Energy Generation and Improving Current Disaster Risk Management' (CLIMFOR).

assistant: **Concept**

6,873 natural disasters happened worldwide in the period 1994-2013 (e.g. floods, drought, and other extreme weather phenomena) killing 68,000 people and affecting 218 million more annually. The early implementation of Disaster Risk Reduction strategies strongly depends on the availability of reliable seasonal forecasts. But global, long-term climate forecasting models are used for seasonal prediction and they are very inaccurate as they have not been designed to this end. On the other hand, the intermittent nature of renewable energy sources is a challenge to grid operators, utilities and plant managers as they attempt to anticipate energy output. Reliable weather forecasts enabling an accurate prediction of energy generation in order to balance production and demand is key to boost the production of renewables and their smooth integration into the grid. Current weather forecasts used by this industry do not focus in predicting relevant variables for the energy sector (such as solar radiation). At geopredict we have put the most recent mathematical algorithms based on Artificial Intelligence into the task of revolutionising atmospheric forecasts and have created CLIMFOR, an intelligent, probabilistic, forecasting engine based on earth observation and in-situ data producing very reliable seasonal (medium-term: from few weeks up to a decade) forecasts with high spatial resolution (down to 1x1 km). With CLIMFOR we aim at improving the way we currently deal with the risks and opportunities arising from global change through climate negotiations, sustainable development policy, humanitarian aid and crisis management, as well as enabling a smooth integration of renewable energy sources into the grid. By targeting the renewable energy providers, disaster risk reduction players
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'B-resonance Algorithm using Rare Decays' (BARD) targeting Horizon Europe.

assistant: **Abstract**

The Standard Model (SM) of particle physics provides a cogent, yet incomplete, description of matter and its fundamentalinteractions. Many theories aim to describe particles and forces beyond the SM of particle physics, but after ten years of data taking atthe Large Hadron Collider (LHC) and hundreds of experimental measurements, only one deviation from the predictions of the SM hasbeen observed .The Standard Model (SM) of particle physics provides a cogent, yet incomplete, description of matter and itsfundamental interactions. Many theories aim to describe particles and forces beyond the SM of particle physics, but after ten years ofdata taking at the Large Hadron Collider and hundreds of experimental measurements, only one deviation from the predictions of theSM has been observed in a series of semi-leptonic decays of B-mesons (B anomalies). It is undeniable though that the third generationof fermion families have a special role in the SM and beyond and their study represents the pathway towards accessing new particlesand forces. Taking into account the current exploitation of LHC data and the constraints set to new particles and forces in recentyears, it is time to devote greater scientific focus to the search for new light particles that specially couple to third generation quarks.These particles might be within reach of the LHC, but haven’t been discovered yet due to experimental limitations (triggers). BARD isa new experimental technique that overcomes the limitations of light particle searches and provides a new way of performing dataanalysis searches for these particles. BARD will achieve this goal by advancing high-momentum resonance search methods usingtools specific to the low-momentum B-physics field, in order to increase the available dataset and sensitivit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Systems Level Approach to Proliferation and Differentiation Control in Neural Stem Cell Lineages' in the context of a Seventh Framework call.

assistant: **Objectives**

The aim of this proposal is to understand how self-renewal is controlled in neural stem cell lineages and how defects in this process can lead to the formation of brain tumors in model organisms. The system we use are Drosophila neuroblasts, stem cell like progenitors in the developing fly brain that undergo repeated rounds of asymmetric cell division. During each division, protein determinants called Numb, Prospero and Brat are segregated into one of the daughter cells where they stop self-renewal and ultimately trigger neuronal differentiation. Mutations in those proteins or their segregation machinery lead to the formation of tumor neuroblasts, which proliferate indefinitely leading to the formation of a deadly brain tumor. The approach we take is to determine the transcriptional network that acts in neuroblasts to control self-renewal. We will use time-resolved transcriptional profiling to determine, how this network changes in the differentiating daughter cell and develop tools for medium-throughput functional analysis of the key network players. We will develop methodology for tissue-specific chromatin immunoprecipitation to determine, how the asymmetrically segregating determinants feed into this network. Using this data set, we will determine the pathological state of the network in the tumorigenic situation. We will determine, how wild type neural stem cells limit their proliferation capacity and how those control mechanisms are affected in the tumor situation. Ultimately, we will expand this analysis to other stem cell systems inside and outside the fly nervous system to determine how modifications of stem cell systems like transit amplifying pools or perpetual adult proliferation are reflected in network architecture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Organic Polariton Laser Diode' in the context of a Horizon 2020 call.

assistant: **Objectives**

The high current density required for population inversion in organic semiconductors has made the realization of an organic laser diode rather challenging. Here, I propose an organic polariton laser diode (OPLD) in which the threshold is achieved through the mechanism of polariton condensation. This conceptually different lasing mechanism does not require population inversion, suggesting that lasing under electrical injection can be, for the first time, demonstrated in organic semiconductors. To date, most commercial laser diodes are based on inorganic semiconductors, which are expensive materials, require complex fabrication and manufacturing processes, and have a limited range of lasing wavelengths. Organic semiconductors, in contrast, are ideal materials for the industrial production of diode lasers and other optoelectronic devices due to their ease of fabrication and processing, low acquisition-cost, and broad spectrum of emission. The realization of the first OPLD within this fellowship will be tremendously important for the European market. In 2014, diode-laser technology comprised 46% of the total revenue ($9.4 billion) in the global laser market. Moreover, emerging automotive lighting (BMW Laserlight) and high-definition laser display (LG LASER display) technologies could enable diode lasers to overtake the global laser market. Therefore, any steps towards the realization of the first organic laser diode (or organic solid state laser) would represent a significant technological and scientific achievement. Furthermore, the proposed device offers a totally new, due to its electrical pumping, platform for fundamental studies of quantum fluids of light.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Inhibition of the potassium channel TREK1 by mTOR: a mechanism for aberrant neuronal excitability in mTORopathies' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Neurological disorders, such as epilepsy and autism, affect millions of people worldwide with the underlying causes ranging from genetic mutations to developmental issues. Treatment options vary widely from anti-epileptic drugs to more severe approaches such as surgical interventions, underscoring the need to understand the underlying causes for developing effective treatment strategies. Among these neurological disorders are mTORopathies, a group of genetic diseases characterized by the dysregulation of the mechanistic Target Of Rapamycin (mTOR) signaling pathway. The most common mTORopathy, Tuberous Sclerosis Complex (TSC), leads to significant health challenges resulting in a reduced life expectancy of 10-20 years for affected newborns. Despite crucial progress in understanding mTOR dysregulation, the precise mechanisms by which it causes neurological hyperexcitability remain unclear, and current treatments present important limitations. This project aims to unravel the molecular mechanisms driving mTORopathies and to develop targeted therapeutic interventions. The first comprehensive study of phosphorylation landscape in TSC brain in the host laboratory has identified TREK1 potassium channel as a novel target, potentially playing a critical role in the development of epileptic seizures. Using a range of multidisciplinary approaches, from molecular and cell biology techniques to neurological analyses, I aim to gain invaluable insights into the molecular mechanisms underlying mTORopathies. Furthermore, by generating mouse models with modulated TREK1 activity, I aim to identify novel therapeutic strategies to counteract TSC. Understanding the molecular program underlying these diseases is essential to develop targeted therapies that improve patient outcomes. This resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural insights into binding signatures of transcription factors regulated by HIPPO signalling' (HIPPOSTRUCT) targeting Horizon 2020.

assistant: **Abstract**

Transcription factors (TFs) are proteins which recognize specific DNA-sequence to orchestrate various gene expression programs according to cellular requirements. Currently, approximately 1,600 TFs along with their binding motifs have been annotated. Further, recent studies enabled classification of many of them according to their binding modes across nucleosome assembly. Despite such progress, interplay of different TFs in the context of adjacent DNA sequence or spatial organisation of chromatin is still largely unknown. This project aims to dissect crosstalk between different TFs that are targeted by HIPPO signalling pathway, a tumour suppressor pathway representing potential target for anti-tumour therapies. Preliminary data from host lab combined with previous studies from other groups lead us to postulate hypothesis that TFs from TEAD and FOX groups cooperate on regulation of transcription programs controlled by HIPPO pathway. Specifically, FOX TFs act as chromatin re-modellers enabling TEADs binding to the naked part of DNA which then triggers desired gene expression programs. To test this hypothesis, we will combine bioinformatic searches across human genome with experimental work assessing intermolecular binding between TFs and DNA, followed by structural characterization of selected macromolecular complexes. We will identify genomic loci which contains binding motifs for both TEAD and FOX TFs. These DNA fragment will be tested experimentally in terms of their ability to physically interact with both TFs, which will provide mechanistic insight into their cooperation. Finally, 3-D structure of the reconstituted complexes containing TF pairs bound to DNA will be determined using advanced mass spectrometry combined with high-resolution structural techniques such as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Precompetitive Steps of Virtual Transparency and Augmented Laparoscopy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Laparoscopy allows the surgeons to treat pathologies such as cancer with considerably less trauma for the patient than classical open surgery. The laparoscope is a small camera inserted in the patient’s abdominopelvic cavity. Laparoscopy has been used for decades but still suffers from the impossibility of seeing the organs’ inner anatomy. This forms an important limitation because it slows down surgery, prevents finding some tumors and dramatically limits the use of laparoscopy. ViTAL (Virtual Transparency and Augmented Laparoscopy) is a concept specifically developed by our group of scientists, surgeons and radiologists as a solution to the current hidden-anatomy limitation of laparoscopy. The ViTAL concept is to modify the laparoscope’s video in realtime to emulate organ transparency and to highlight features invisible to the naked eye. The proposed project P-ViTAL (Precompetitive steps for ViTAL) aims at developing a precompetitive software implementation of ViTAL. Technically, ViTAL exploits information extracted from routine radiological images such as Magnetic Resonance Images (MRI) acquired before surgery. Such a combination of visual information cannot be achieved mentally, even by experienced surgeons.Concretely, P-ViTAL has two objectives: 1) to develop a precompetitive prototype and 2) to create communication material. Objective 1) will be achieved by improving and extending the functional research prototype obtained in ERC project FLEXABLE. Two engineers will be hired to assist the team in this task. Objective 2) will be achieved by working with a communication agency. In particular, we aim at producing promotional brochures, images and video clips of laparoscopic surgery procedures achieved with ViTAL. P-ViTAL comes as the next important step towards our g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Guarding Genome Stability: Dynamic Control of Chromosome Segregation by Kinetochore Signalling Pathways' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Equal segregation of chromosomes during cell division is vital to all life. Using a unique combination of cell biological and biochemical techniques, I will show how an essential set of enzymes promotes error-free chromosome segregation. During each cell division, genetically identical daughter cells are generated by accurate partitioning of the duplicated chromosomes. This relies on proper spatio-temporal execution of various highly dynamic processes. The activity of a small group of enzymes is crucial for at least two of these processes: correct chromosome positioning on the cell's equator prior to cell division and the ability to prevent cell division until every chromosome is thus positioned. The molecular fundamentals of signalling to and from these enzymes will be uncovered by chemical genetics, quantitative (phospho)proteomics, rapid affinity purifications and live-cell deconvolution microscopy. The resulting insights will open research avenues that will ultimately contribute to comprehensive models of how biochemical networks manage to prevent chromosome mis-segregation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Creating a joint Research Agenda for ICT Innovation in the Creative Industries across Europe'.

assistant: **Innovation**

The proposed project CReATE is based on the cooperation of highly innovative clusters in the creative industries, one of the emerging lead markets of the European knowledge economy.  With the objective to bring the benefits of research to SMEs, the largest group in those clusters, the project facilitates an “open innovation” approach. It incentivates and enables a more systematic use of the innovation potential of information & communication technologies (ICT), key for developing internationally competitive products and services. To strengthen the research potential of EU regions, and to increase related investments from EU, national & regional funds, CReATE targets to position regional capabilities in the most promising international technology and market development perspectives. Prospective tools and a focus on the trans-regional dimension complement the traditional tools to lay the ground for self-sustaining economic success. Thus, CReATE promotes synergies between regional, national, EU & research policies, and facilitates intra- and trans-regional cooperation and knowledge exchange between cluster development agencies, researchers, SMEs and MNEs. To optimise outcomes, the Consortium Members have working relationships already proven successful, and can add European value with their complementary contributions. They bring in-depth knowledge of creative industries, practical cluster development and the underlying theories, and of providing strategic economic and policy intelligence in general. To optimise CReATE’s contribution to the objectives of the call we plan to  1) develop and apply a new assessment template 2) develop a joint research agenda 3) develop a toolkit, and implement training courses for interested regions, also for other clusters 4) ensure multiplyi