RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Digital mock-up-modelling methodologies and tools for product conception and downstream processes' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives and content Current industrial practice in automotive, aerospace and other manufacturing industries involves the creation of physical product models (physical mock-ups) as a hip to designers, manufacturing planners, etc. The objective of the(se) project(s) is to depart from this practice and develop the technology that allows designers, manufacturing planners and even the management to work on Virtual Products /Digital Mock-Ups (DMU). They can make decisions related to the concept, design and all downstream processes. This technology will allow companies to work in a concurrent engineering environment independent of their size and product configuration. To achieve this goal a cluster of projects including modelling methodologies, simulation, visualisation, etc. (see figure below) is proposed. Within this cluster of projects the objectives of the Digital Mock-Up Modelling Methodologies and Tools (DMU-MM) project is to develop methodologies and tools which allows the designer to model, evaluate, and geometrically represent the product design from initial concept stage through to downstream processes within the software (without having to build expensive physical mock-ups) and to have only one final verification in hardware. Furthermore, to introduce these methodologies and tools in an innovative use within the business process enabling the designer to geometrically design and model assembly parts and subassemblies covering the total product cycle-design, prototyping, production, maintenance and recycling. The-benefits of this technology will include: Potential reduction in design lead times of between 20-30%. The DMU-MM will be available much earlier in the design process, offering different views and alternative designs and will model many more aspects of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Delivering BEACON Caresystem – a ground-breaking ICT-enabled ICU bed-side assistant providing recommenda-tions for critical mechanical ventilation support for better care and reduced costs.' (ICU-CARE) under Horizon 2020.

assistant: **Objectives**

We are Mermaid Care - provider of leading ICT-based care systems for optimizing Ventilation Management within the Intensive Care Units (ICU) and anesthesia segment. ICUs are some of the most resource-demanding hospital units consuming 20% of all hospital costs. A major contributor is the Length of Stay (LOS) of ventilated patients. Key to reducing costs is to reduce LOS. The process is difficult, as doctors have to decide on the proper ventilation strategy in a matter of minutes during his/her few daily rounds. Studies show that LOS can be drastically reduced if experts oversee the ventilation management 24/7 – clearly not a sustainable solution, we see a clear need for an ICT-based advisory system to aid 24/7 management. We will deliver BEACON Caresystem – a breakthrough ventilation assistant. BEACON will potentially reduce LOS with 15-25% – additionally cutting ICU costs with the proportional amount. As an add-on to existing ventilation systems, it provides optimal ventilation recommendations based on non-stop, personalised monitoring. Basically a bed-site specialist. Based on unique diagnostics algorithms and physiological models, it recommends weaning off scenarios, supporting the critical decision-making processes. No one else offers this diagnostic and physiology-based approach (individualised care). The ICT-approach means BEACON changes workflow and empowers ICU nurses to take over a vast part of the management.In the proposed project, BEACON value proposition (LOS reduction) will be clinically documented. Following the project, BEACON is launched on the EU market, allowing European hospitals to cut ICU costs and improve healthcare procedures. This project will allow us to accelerate sales volume from €0.8M in Y1 to €43M in Y5 and create 30 new European work plac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development' (ESCALON) targeting Horizon 2020.

assistant: **Abstract**

Hepatobiliary malignancies represent a major cause of mortality globally and are uniquely aggressive in Latin America. The most common tumors are: hepatocellular carcinoma (HCC) affecting young individuals in Latin America and being the second most common cause of cancer-related death worldwide; cholangiocarcinoma (CCA) with minimal survival upon diagnosis and largely understudied in the region; gallbladder cancer (GBC) being a rare tumor worldwide but representing the second most common cause of cancer-related death in women in Chile. Key factors related to the excessive mortality of these tumors are the lack of reliable screening methods and the complexity of diagnosis, which requires advanced imaging technology and difficult-to-access tissue. These barriers are amplified by poor accessibility present in resource-limited regions, all of which leads to tumors being diagnosed at advanced stages in which curative therapy is not an option. To overcome these barriers, we propose to: A) validate immune-related markers in serum to predict HCC in South America and evaluate factors associated to early HCC development; B) define the utility of extracellular vesicles in serum as biomarkers for diagnosis of CCA and determine genetic and infectious factors that increase risk for this cancer; and C) identify biomarkers for GBC detection and evaluate novel immune factors that affect the geographical impact of this tumor. This project advances the field by focusing on a unique approach to screen and diagnose tumors based on serum detection of biomarkers before a tumor is visible on imaging, allowing for early tumor detection in a cost effective manner that will lead to implementation of curative therapies. In addition, this project addresses modifiable risk factors for hepatobiliary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SAfeguarding female FERtility -development of human-relevant in vitro tools for reproductive toxicity' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Chemical health risk assessment has failed to safeguard fertility in women. Women and their oocytes are exposed to pervasive mixtures of human-made chemicals that correlate with reproductive ageing and infertility. Only 0.5% of the chemicals on the European market have been well characterized for health risks, and reproductive toxicity in women is typically not covered due to missing tools. The new European Growth Strategy aims at sustainable growth, zero-pollution and safe chemicals. While the need for increased chemical testing is tangible, there is a movement to phase out animal experiments. This creates a huge challenge to deliver on the vision of a safe and toxic-free environment. Here, I will develop new high-content assays for reproductive toxicity in women. SAFER is built on my exceptional ovary biobank, established stem cell lines, and multi-omics technologies. Using chemically exposed ovarian tissue and stem cell derived blastoid cultures, SAFER will map mechanisms mediating toxicity by high-resolution epigenetic and transcriptomic analyses. Model chemicals are chosen based on ubiquitous presence in women and significant associations to decreased ovarian function, as shown by my cohort studies. The identified mechanisms will be tailored into reporter genes that I will insert into new immortalized human ovarian cells as well as stem cells, and develop into high-content screening assays. The product of SAFER is novel in vitro tools for screening of female reproductive toxicants.Taken together, SAFER sets an example for animal-free derivation of assays for chemical safety assessment. SAFER tools will contribute to identification and restriction of chemicals that pose a hazard to women’s health. This is an important step in the global movement towards a non-toxic,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European-Chinese Research Staff Exchange Cluster on Marine Biotechnology' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Marine biotechnology is one of the most exciting emerging fields of technology. It becomes more and more important in many areas of application such as the production of new drugs, food ingredients, agrochemicals, and cosmetics. More recently, it was found that some products of marine organisms are also of extreme importance in the rapidly growing field of nano(bio)technology, another technology of the future. These developments have been recognized by the European Commission as well as by national funding organizations in Europe and in China, which included marine biotechnology and nano(bio)technology in their priority research programmes. Both the European Research Area (ERA) and China as one of the main players in the Asian-Pacific Research Area (APRA) are in the worldwide lead in marine biotechnology and nano(bio)technology regarding to the number of publications and patent applications. However, different sectors of these technologies are differently developed in Europe and China, suggesting that a combination of the complementary expertise in these sectors will be of benefit to both partners. The proposed international staff exchange programme is based on three institutions in Europe and four institutions in China (universities and research organizations including marine stations) with a number of top-ranked research groups in the field of marine biotechnology, drug discovery/natural products chemistry, biomineralization and material sciences / nanotechnology. The objective of the project is to create an efficient and successful programme for the transfer of knowledge between the partners by the exchange and training of staff (both early-stage researchers and experienced researchers) of the participating institutions. The goal is a lasting integration of the resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Detecting protease substrates using unnatural amino acids' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

There are aminoacyl transferases, such as arginyl tRNA protein transferase 1 (Ate1) in Eukaryotes and leucyl/phenylalanyl tRNA protein transferase (L/F transferase) in Bacteria.  Both enzymes recognize specific N-terminal amino acids of a target poly-peptide and conjugate an amino acid from an aminoacylated tRNA onto the N-terminus of the targeted poly-peptide.Ate1 conjugates an arginyl moiety onto the N-terminus of a poly-peptide.  Electrospray ionization of peptides critically depends on arginyl moieties to stabilize proton charges to the peptide.  Taking both facts together, there is a huge untapped potential for Ate1 in the workflow of mass spectrometry facilities by providing an additional proton charge-stabilizing moiety to a peptide's N-terminus.With my proposed project I further aim to harvest the ability of L/F transferase to conjugate a single amino acid, including unnatural amino acids, to the N-terminus of specific target poly-peptide and covalently tag the N-terminus of proteins.  The proteins of interest are proteolysis fragments, which will be positively enriched by taking advantage of the unnatural amino acid moiety and analyzed using mass spectrometry.  The monitoring of proteolysis products has far reaching implications as proteolysis is an important causal or progression factor in various diseases such as neurodegenerative diseases, chronic inflammation, cancer and heart disease.During my post-doctoral studies at the University of Alberta, Canada, I characterized the kinetic parameters of both L/F transferase and Ate1 extensively.  As Marie Curie International Incoming Fellow, I will build on my previous knowledge in a team of biochemists, cell biologists, computational biologists, and mass spectrometrists to establish sound methodologies for clinical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Low dimensional semiconductors for optically tuneable solar harvesters' to be submitted under Horizon 2020.

assistant: **Abstract**

SENSATE proposes ground breaking ideas and concepts combining very innovative low dimensional thin film materials and highly asymmetric selective contacts with dipoles, for the development of non-intrusive and universal solar energy harvester. Materials, processes and devices design innovations will be combined in a straightforward manner, in order to develop next generation of cost-efficient and highly-stable/optically-tuneable photovoltaic (PV) devices.For achieving this, SENSATE proposes exploiting for the first time the full optical and electrical potential of one-dimensional (1D) thin film wide bandgap materials, including chalcogenide, halide and mixed chalcogenide/halide compounds. The use of 1D semiconductors as PV absorbers will represent a breakthrough thanks to their unique capability to exhibit excellent electrical properties in very thin layers when correctly oriented, keeping at the same time tuneable optical properties to ensure good transparency (AT > 50%), and very competitive efficiencies (>20%). A wide range of wide bandgap 1D semiconductors will be developed (Eg between 1.50-2.70 eV), including strategies for their 1D texturing using annealing at high pressure and under magnetic fields.This will be combined with disruptive selective asymmetric contacts based on electron and hole transport metal oxide layers, enhanced with superficial organic and inorganic dipoles, to develop a ubiquitous solar harvester with customized transparency/efficiency. If succeed, SENSATE will have an unprecedented impact in our perception of PV energy, opening the possibility to applications that nowadays are considered marginal. Transparent, semi-transparent and coloured devices for advanced BIPV applications and electronics, as well as top cells for very high efficiency an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Food Trade Dependency under Climatic & Socio-Political Shocks: Managing Risk (F-TRADEMARK)'.

assistant: **Innovation**

Policies in developing countries that seek to fight hunger, achieve food security, improve nutrition, and promote sustainable agriculture (a United Nations Sustainable Development Goal), face considerable obstacles when confronted with disruptions of their staple food production and trade.  Disruptions such as climate change along with inter-state conflicts, e.g., the ongoing Russian invasion of Ukraine, have weakened developing countries’ staple food yields, supply, and trade flows. For trade in particular, challenges include physical trade disruptions of agricultural outputs, as well as inputs, particularly in more vulnerable regions. These disruptions are often followed by government trade interventions. A critical dimension of food risk and security is staple food trade dependencies between countries.  Such dependencies occur both directly, in terms of regional food security, and indirectly increase migration as well as gender vulnerabilities. Indirect dependencies emerge from the complex web of trade relationships in which a country's access to staple foods relies not only on direct imports from producing nations but also on re-exports facilitated by intermediary countries. In the case of disruption shocks, such a trade system may expose importing countries to vulnerabilities at various intermediary points. For example, the Russian-Ukraine war has exposed the vulnerability of countries directly importing staple foods and fertilizers from the two countries, but also heavily affected countries that rely on the re-export of staple foods. The project F-TRADEMARK aims to measure the vulnerability of nations’ food systems resilience based on global trade data from 1986 – 2020 using network-based assessment tools. Moreover, the future of staple food and fertilizer trade d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Multi-functional, multi-material magnetic components and structures for electrification' (MultiMag).

assistant: **Concept**

Electric machines and drives, including various types of electric motors, play an ever-increasing role in the way of making Europe the first climate neutral continent in the world. In order to achieve a breakthrough in the field of energy efficient electric motors, novel approaches are needed: high performance sustainable materials and multi-material manufacturing technologies suitable for complex geometrics and capabilities to design and simulate structures and components based on those.  The ambitious goal of MultiMag is to develop novel design tools, high performance materials and multi-material additive manufacturing (MM-AM) processes, hence, to manufacture ready assembled lightweight components for electric machines and leading to better performing machines, improved energy efficiency and shorter lead times. After use, the components can be dismantled, and the materials recycled effectively. MultiMag takes the full advantage of multi-material additive manufacturing. Stacked rotor and stator structures, combining dissimilar magnetic and electric insulating materials are developed, manufactured and validated to ensure mechanical, thermal, electrical and magnetic performance. Internal structures, enabling more efficient cooling, are studied and designed. Achieving ambitious objectives of MultiMag requires a holistic approach and innovations in all sectors, namely in design, materials, manufacturing, use and end-of-life. Each of these vital areas are addressed by MultiMag activities. We will develop a framework and specific toolbox for addressing complex design challenges, which are multi-material, multi-functional and multi-physics. Evaluation and development of matching material properties enabling to join dissimilar materials using AM processes is one of the key foc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Advancing International Co-operation and Developing Infrastructure for Targeted Screening of Prostate Cancer in Men with Genetic Predisposition'.

assistant: **Objectives**

In the EU, approximately 200k men are diagnosed annually with prostate cancer, and this figure is likely to increase due to the ageing population, causing a considerable health care problem. Inherited genetic factors are important in this disease, for example the breast cancer predisposition genes BRCA1 and BRCA2 have been reported to increase significantly the risk of prostate cancer. The European IMPACT study (scheduled to begin in 2005) aims to put in place networks and infrastructures in 23 countries (18 in Europe) to identify a male population harbouring germline mutations in the BRCA1 and BRCA2 genes and recruit them into targeted screening programs for prostate cancer. IMPACT also aims to support future research into the targeted screening and clinical management of prostate cancer in high-risk individuals. The main goal of this proposal (AIDIT) is to stimulate co-operation with Associated Candidate Countries in relation to the IMPACT study. It is intended that a Specific Support Action (SSA) could provide the means to identify and recruit appropriate centres in the ACCs; stimulate the participation of research teams in ACCs and connect expertise in all collaborating countries in this area. Networking and dissemination of the latest results from ongoing prostate cancer screening studies are crucial elements of this proposal, which has the long-term aim of enabling centres in the ACCs to join the IMPACT study, thus establishing a larger consortium and research base. AIDIT is also aimed at raising the profile of the need to improve clinical management of prostate cancer, educating the relevant stakeholders, improving quality of life, reducing early mortality and reducing the financial burden of health care. It will consider relevant gender, ethical and societal iss