RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Computational Simulations of MOFs for Gas Separations' (COSMOS), addressing dissemination and exploitation.

assistant: **Impact**

Metal organic frameworks (MOFs) are recently considered as new fascinating nanoporous materials. MOFs have very large surface areas, high porosities, various pore sizes/shapes, chemical functionalities and good thermal/chemical stabilities. These properties make MOFs highly promising for gas separation applications. Thousands of MOFs have been synthesized in the last decade. The large number of available MOFs creates excellent opportunities to develop energy-efficient gas separation technologies. On the other hand, it is very challenging to identify the best materials for each gas separation of interest. Considering the continuous rapid increase in the number of synthesized materials, it is practically not possible to test each MOF using purely experimental manners. Highly accurate computational methods are required to identify the most promising MOFs to direct experimental efforts, time and resources to those materials. In this project, I will build a complete MOF library and use molecular simulations to assess adsorption and diffusion properties of gas mixtures in MOFs. Results of simulations will be used to predict adsorbent and membrane properties of MOFs for scientifically and technologically important gas separation processes such as CO2/CH4 (natural gas purification), CO2/N2 (flue gas separation), CO2/H2, CH4/H2 and N2/H2 (hydrogen recovery). I will obtain the fundamental, atomic-level insights into the common features of the top-performing MOFs and establish structure-performance relations. These relations will be used as guidelines to computationally design new MOFs with outstanding separation performances for CO2 capture and H2 recovery. These new MOFs will be finally synthesized in the lab scale and tested as adsorbents and membranes under practical operating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Preparing for an influenza pandemic (FLUPAN)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Evidence from the Hong Kong chicken influenza outbreak has made us aware that we are ill prepared to produce conventional egg-grown influenza vaccines in response to a pandemic. This project will use reverse genetics to modify avian or swine influenza viruses, so that they are safe to use and grow well on mammalian cells. An MDCK or Vero cell vaccine will be produced from a highly pathogenic avian virus, modified so that it is attenuated. The vaccine will be evaluated pacifically and clinically. We will also produce a library of reagents from a variety of avian and swine viruses for use in eggs or cell culture vaccine manufacture and develop new techniques for monitoring transmission of animal viruses to man.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'pioneer technology for the reduction of natural fruit sugars in 100% juices', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

One of current challenges in Food and Beverage industry is linked with the need to reduce natural sugars. In fact, despiteinitial enthusiasm for natural fruit juices, recent studies have demonstrated the natural sugars are as much harmful as addedsugars do. Thus, producers are focusing on the development of affordable and efficient technologies to deliver de-sugarizedproducts. However, to date no optimal industrial solution in this domain has been implemented. The BetterJuice technologyoffers something that has not been reached yet by other companies. We reduce and even eliminate natural sugars from fruitand vegetable matrix, without affecting the organoleptic skills of the product and even improving its taste. Calories reductionis achieved to at least 50%. Moreover, we are able to offer a really healthy choice for consumers because beveragesproduced with our technology are naturally enriched with bio-available and thus easily absorbable Calcium. The technologydoes not require the modification of the existing production lines and its impact on the production costs has been assessedat € 0,1 per 1 litre fruit/vegetable matrix. This low cost factor, along with the ascertained readiness of consumers to switch tohealthier hydration even if on higher price, offers the opportunity to producers to create novel product lines with appealingclaims and thus setting the price point that can significantly maximize their profit margins. The BetterJuice technology usesdisruptive bio-conversion approach delivered through enzymatic activity of food grade microorganisms. The technology is ofinterest of some of world leading juice producers. Current project will enable us to collect users' requirements and thus toproperly engineer the industrial prototype of the device. Furthermore, a deta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A EUROPEAN CYBER RESILIENCE FRAMEWORK WITH ARTIFICIAL INTELLIGENCE -ASSISTED ORCHESTRATION & AUTOMATION FOR BUSINESS CONTINUITY, INCIDENT RESPONSE & INFORMATION EXCHANGE' (PHOENI2X) under Horizon Europe.

assistant: **Objectives**

PHOENi²X aims to design, develop, and deliver a Cyber Resilience Framework providing Artificial Intelligence (AI) - assisted orchestration, automation & response capabilities for business continuity and recovery, incident response, and information exchange, tailored to the needs of Operators of Essential Services (OES) and of the EU Member State (MS) National Authorities entrusted with cybersecurity. Through the deployment PHOENi²X Cyber Resilience Centres (PHOENi²X CRCs), OES will gain: (i) enhanced Situational Awareness with AI-assisted Prediction, Prevention, Detection & Response capabilities, and business risk impact assessment-based prioritisation; (ii) proactive and reactive Resilience Automation, Orchestration, and Response (ROAR) mechanisms, providing Business Continuity, Recover and Cyber & Physical Incident Response; (iii) Increased Preparedness through relevant Serious Games and realistic Resilience Cyber Range (RCR) Assessment & Training; (iv) timely and actionable Information Exchange between OES, National Authorities and EU actors, leveraging interoperable and standardised alerting and reporting mechanisms and processes.


**Keywords:** Incident response, SOAR, playbooks, CTI, situational awareness, cyber range, Training and awareness, Attack prediction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Coordination of European Research on Emerging and Major Infectious Diseases of Livestock' (EMIDA).

assistant: **Innovation**

The disease threats to the livestock industry have increased steadily over the past decades as a result of globalisation, evolving pathogens and climate change. Responding to animal disease threats relies heavily on science; research makes a significant contribution to the development of disease control policy and the translation of policy, and other drivers for improving animal health, into practical effect.  Although the legislation that underpins policy for the control of statutory diseases is determined at the EU level, the research that supports policy development and implementation is primarily carried out at the national level and is largely uncoordinated as is the research on other major infectious diseases currently affecting livestock production. The aim of the Animal Health ERA-NET is to build on and accelerate the work of the SCAR CWG in developing a durable focused network of national research funders in Member and Associated States of the EU for the purpose of sharing information, coordinating activities and working towards a common research agenda and mutual research funding activities in the field of animal health.  The scope of the project will include emerging and major infectious diseases of production animals, including fish  and bees and including those conditions which pose a threat to human health but excluding food safety issues relating to livestock products and diseases of wildlife except where they act as reservoirs of infection for humans or production animals.   The objectives of the ERA-NET will be delivered through the following  four workpackages:  WP1.  Project coordination, management, communication and dissemination;  WP2. Mapping and analysis of existing research and current needs and information on the commissioning and management of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Electronic portal imaging device based on multi-cell gaseous detector with metallic gamma ray converter for cancer radiotherapy' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The importance of the placement of treatment portals to achieve local tumour control is objectively documented. There is a need for technology to provide real time or near real time images of patient anatomy with high energy X-ray during treatment on linear accelerator. New detecting technique is proposed for hard X-ray imaging for on-line monitoring of the position of irradiated field of patient corps during radiotherapy treatment. The proposed imaging technique is based on coupling of highly sensitive gaseous detector to a heavy metal gamma rays converter. The converter should be used because of very small conversion cross section in gaseous medium of high energy gamma rays. High detection efficiency of the detecting module and its very good position resolution should assure image of good contrast with minimal radiation dose. Application of the electronic portal imaging device increases the quality of the therapy and minimises a risk brought to a patient. The scope of the project is to determine characteristics of the high energy X-ray radiography method as well as technical feasibility of the device. The research intended will complete the evaluation of expected performance of the proposed measurement using small model. The model of the detecting element will be constructed and it will serve for the development and test of dedicated data acquisition electronic chain. This should permit to define some elements of the detecting technique for further development of scale imaging device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ORIGANUM SP. AND SALVIA SP. : INTEGRATED BREEDING RESEARCH TO IMPROVE HOMOGENEITY AND QUALITY OF MULTIFUNCTIONAL SECONDARY PLANT PRODUCTS' (1994-1998).

assistant: **Innovation**

The food and pharmaceutical industry is more and more demanding homogeneous high quality raw material for a better standardization of their high quality output products. In aromatic and medicinal plants this aim could only be reached punctually (e.g. in chamomille).Several Lamiaceae, used as aromatic and medicinal plants, contain essential oils and diterpenes with marked antimicrobial and antioxidant properties. These secondary metabolises have potential applications in a number of important areas, including food & beverages (flavorings), agriculture & horticulture (disease prevention) and pharmaceuticals & cosmetics (spoilage prevention). New applications in the nutraceutical field are now being realised for antioxidants wherein they act as protectants of key polyunsaturated fatty acids (PUFAS) in mammalian tissues and organs. The objective is to screen a collection of genotypes of plants grown in this project to learn about the genetic and environmental variability of secondary metabolises important for above mentioned activities.A hybrid breeding system will improve homogeneous quality and can now be applied to marjoram (Origanum majorana L.). Genetic melioration of oregano species (Origanum sp.) and two sage species (Salvia officinalis L. and Salvia fruticosa Miller) will be performed by using a selection program of selfings of chemotypes.Although the main cultivation areas of marjoram in Europe are located in Central Europe (Germany and France), the seed production should be transferred to and established in Mediterranean regions, where perennial production of marjoram is possible and an increase of seed production by the factor 2 to 3 compared to annual production seems likely, but is not proven yet. Marjoram is continuosly producing seeds over a long period, so o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multiple model architectures for intelligent modelling and control' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

This project aims at the further development of learning systems which allow the developer to introduce a priori knowledge. Such approaches bring structure into the learning task, improving performance and robustness, as well as leading to more interpretable trained systems. The project will combine existing approaches such as Local Model Networks and Markov Mixtures of Models into a single framework which will then be made available to other researchers in the form of a MATLAB toolbox, including visualisation tools. This toolbox will be open to a number of techniques including fuzzy logic and belief networks. The project will involve partners from Germany (Daimler-Benz research, DLR Braunschweig), who will provide data to test the methodology for real world applications from autonomous robotics and helicopter modelling. Other partners in Britain (Univ. of Glasgow) and Norway (SINTEF research) will collaborate on the theoretical aspects of easing the combination of learning from data while introducing human knowledge and insight.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Madrid Innovation Relay Centre'.

assistant: **Objectives**

The strategy of Madrid IRC during the period 2004-2008 will be focused on solving technological problems emerged from Madrid SMEs. In that sense, those tasks related to the identification of technological needs as well as the management of technology reque sts have been strengthened with regards to the 2000-2004 project. During the proposal period, Technology Watch reports will be carried out as part of the commercialisation processes, trying to reach a better quality of services. Such reports will have a double utility; on one hand, a technology watch analysis has shown a valuable tool for the preparation of technology offers. On the other, Madrid IRC will use such analysis as support for inward technology transfer processes. Also, during the next acti vity period, Madrid IRC will develop other added value services oriented to give better support to regional clients. The acquired experience will be shared with the IRC network by presentating of good practices, participation and contribution in workshop s and direct collaboration with other IRCs. Related to the networking activities, two main objectives have been identified as priority for the next period. First, Madrid IRC will continue its activity in the pilot activities promoted by the C.U. oriented to improve the quality of the results and also will increase its participation and visibility in TT events.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The first ingestible capsule for eradicating Helicobacter pylori infection through photodynamic therapy'.

assistant: **Innovation**

Helicobacter pylori (H. pylori) is a bacterium of the stomach which affects on average 50% of the world population, reaching up to 70% in some European Countries. Once it is diagnosed, it has to be eradicated, since it is a carcinogen agent and around 90% of all gastric cancers can be attributable to its infection. The only available treatment is a pharmacological therapy based on the assumption of proton-pump inhibitor and a mix of 2-3 antibiotic drugs. Unfortunately, due to increasing antibiotic resistance, up to 30% of the affected population cannot be cured, despite several cycles of antibiotic therapy and usually endoscopic biopsy to determine antibiotic-resistance. Probiomedica is a spin-off of the University of Florence and Scuola Superiore Sant’Anna specialized in photobiology and robotics applied to medicine, which has developed and patented CapsuLight, the first ingestible capsule able to eradicate H. Pylori infection through intragastric photodynamic therapy, that is through the power of light. The device is based on the established technology and safety of endoscopic capsules for diagnostic use, and our preliminary in vitro tests showed 97% efficacy in killing the bacterium. The advantages for infected population are unparalleled: the possibility to eradicate the bacterium for those who cannot be cured due to antibiotic resistance (our first target market); the higher efficacy rate, no side effects due to antibiotic cycles, and easy posology for all the infected population (secondary market). CapsuLight will also provide high economic savings to National Healthcare Systems, by reducing drug therapies cycles and endoscopic biopsies and related costs for hospitalization. Probiomedica has already presented the product to several gastroenterology and microbiolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Tricyclic Peptides for the Development of Therapeutics' under Seventh Framework.

assistant: **Concept**

Peptide macrocycles can bind with high affinity and selectivity to protein targets and are an attractive class of molecules for the development of therapeutics. Recently, a phage display-based strategy was developed that allowed to generate potent bicyclic peptide antagonists (Heinis, C., et al., Nat. Chem. Biol., 2009). While bicyclic peptides with nanomolar affinities to a range of protein targets could be generated, it was more difficult to obtain high-affinity binders to some proteins, particularly to those having flat surfaces and no clefts or cavities. Herein, I propose to develop rigid, tricyclic peptides that should, due to a more defined three-dimensional structure, bind to flat surfaces similar as antibodies. Two formats are envisioned for the synthesis of tricyclic peptides: in the first one, a linear peptide is anchored via four cysteine residues to a small molecule while in the second format, bicyclic peptides will be generated and their two peptide rings are connected via Huisgen cycloaddition reaction to impose an additional conformational constraint. Phage-encoded combinatorial libraries of these peptide folds will be generated and subjected to affinity selections. Tricyclic peptide binding to a variety of biological targets including (a) the well-characterized cancer-associated targets EGFR and HER2, and (b) the more challenging target of the antibiotic vancomycin, the short peptide D-Ala-D-Ala, will be developed.