RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Pan-European twinning to re-establish world-level Neuroscience Centre in Kiev (NEUROTWIN)' (NEUROTWIN) targeting Horizon 2020.

assistant: **Abstract**

The overarching goal of the NEUROTWIN proposal is to re-establish the Bogomoletz Institute of Physiology (BIPH) in Kiev, Ukraine as an international centre for excellence in Cellular and Molecular Neuroscience. This goal is set against a sound background of the existing infrastructure, intellectual traditions and the highly educated manpower. That is the adherence to modern procedures and international research environment which all have to be strengthened to achieve the European dimension and to integrate the Institute into European networks. We shall capitalise on the existing potential of international networking for excellence in Cellular and Molecular Neuroscience research, through knowledge transfer and exchange of best practice between BIPH and leading institutions from the UK, Austria, Portugal, Sweden and Germany. The specific objectives of the proposal target several key areas. They include implementing modern research approaches to scientific excellence and innovation capacity of BIPH via infrastructural changes, large scale knowledge transfer between partners, increasing competitiveness of the BIPH researchers in fundraising from international grant bodies. The quality of the scientific output of BIPH will be improved through continuous training of research staff in academic writing and boosting the quality of post-graduate education. NEUROTWIN will help to boost communication with the policy makers and relevant stakeholders in Ukraine to advocate the importance of neuroscience and neurology research for the improvement of public health and biomedical education. NEUROTWIN will step up and stimulate the scientific excellence and innovation capacity in the field of Cellular and Molecular Neuroscience, as well as strengthening scientific collaboration and inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Contagious caprine pleuropneumonia: distribution, evaluation of vaccines and development of new tools' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main objectives are as follows:* To perform serological surveys with a specific test, bELISA, in all countries that declare being infected by CCPP.* To confirm clinical cases by isolation of Mycoplasma capricolum subsp. capripneumoniae (MccF38) and/or by specific PCR.* To compare the efficacy of different vaccines comparatively with the existing one.* To express MccF38 antigens in order to be in a position to evaluate their possible use as diagnostic tools or protective antigens.* To sequence selected genes to facilitate the molecular epidemiology of the strains belonging to the mycoides cluster".Expected OutcomeGaining information on the real distribution of the disease and its real economical impact should facilitate the definition of appropriate vaccination policies. This information is now lacking. The comparative vaccine trials should also facilitate the production of a cheaper vaccine. The demand has been increasing in the past years and it cannot be met by the actual producers.The key activities envisaged are:* The use of specific tools such as a MAb blocking ELISA or PCR for the confirmation of CCPP suspicions. These analyses will be free of charge for developing countries, provided ample informations are given with the samples.* Comparative trials will be made in Kenya and Ethiopia in order to assess the protection afforded by various kinds of vaccines: live attenuated strains or adjuved inactivated ones. Standard procedures for the reproduction of the disease and evaluation of protection should enable inter-laboratory comparisons hence minimizing the number of trials needed.* Develop a phylogeny of the "mycoides cluster" by gene sequencing. Two types of genes will be sequenced, the 16S rRNA which is a standard for such a task and other genes that are speci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A multicentre randomized prospective trial comparing add-on therapy to alternative monotherapy in patients with partial seizures refractory to initial treatment', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To assess the comparative efficacy and tolerability of add-on therapy versus alternative monotherapy in epileptic patients with partial seizures refractory to initial treatment or sequential monotherapies. To determine the optimal therapeutic strategy in epileptic patients with epilepsy refractory to initial treatment or sequential monotherapies, 440 patients with partial non-idiopathic epilepsy who had failed to achieve freedom from seizures despite treatment with a single drug will be randomized to two groups. One group will be crossed-over to an alternative drug having a different mechanism of action (for example, carbamazepine or vigabatrin in patients who had failed on valproic acid monotherapy and valproic acid or vigabatrin in patients who had failed on carbamazepine monotherapy) while in the other group the alternative drug will be added on. In both groups drug dosage will be individualized based on clinical response and serum drug level determinations. Seizure frequency and the occurrence of adverse events will be assessed over a 1-year follow-up period to assess potential differences between the two groups. The primary outcome parameter will be represented by retention time on the allocated treatment policy. Other outcome parameters will include: dissatisfaction time with the allocated treatment policy, time to first seizure after achieving target dosage, proportion of patients achieving at least a 50% reduction in seizure frequency during the last 3 months of follow-up, proportion of patients becoming seizure free and achieving 6-month remission, seizure number at different study periods compared with seizure number at baseline, number of treatment failures, proportion of patients with adverse events.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DEVELOPMENT OF A LOW COST, LOW POWER CONSUMPTION SYSTEM FOR MANUFACTURING LIQUID ICE FOR FISHING' (RECOICE) under Seventh Framework.

assistant: **Objectives**

The aim of RECOICE is to produce ice without use of additional power from fishing boats. RECOICE is based on a heat recovery system that will provide heat (fuel) necessary to drive a Stirling engine. Since heat will be captured from the exhaust pipe of the boat’s existing diesel engine, it will not negatively impact fuel consumption. It is clearly seen, that operating an on-board liquid ice making system ensures better quality products. RECOICE project intends to develop a system that uses waste energy arising from the manoeuvring of the vessel. Recovering energy from the exhaust pipe by a heat exchanger, a Stirling-engine will generate the necessary power to run the cooling unit of the system. Preliminary tests and calculations have proven that during 10 hours long fishing trip the RECOICE system will be able to produce 3 tonnes of liquid ice. This amount is sufficient to cover the ice demand of a small size vessel to conserve its daily catch. Based on the efficiency and power calculations an average vessel could save 11 600 litres of diesel oil a year using RECOICE rather than other commercial on-board ice machines. Considering the average price of diesel oil to be 1.39€/liter, the direct savings in terms of diesel oil expenditures would be 16 000€/year per vessel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Dynamic Combinatorial Nanoparticles for Protein Surface Recognition'.

assistant: **Innovation**

Recent developments in genomics and proteomics have generated an urgent need for new methods of interrogating and targeting biochemical networks. In particular new means of interfering with protein-protein interactions are in high demand and of considerable therapeutic potential. New materials are needed that can recognise and bind to specific protein surfaces. We aim to develop a new approach to the recognition of proteins using individual nanoparticles and dynamic networks of nanoparticles. This requires the development of: 1. Functional nanoparticles capable of selectively recognising proteins. We will explore the potential of dynamic combinatorial chemistry to direct the functionalisation of the surface of the nanoparticles. 2. A means of translating nanoparticle-protein interactions into a signal. Our approach is to use nanoparticle networks that respond to the presence of proteins with a redistribution of their surface functionalisation, which, in turn, produces an optical readout through fluorescence resonance energy transfer. The project is critically dependent on the host's expertise on dynamic combinatorial chemistry and the applicant's expertise on the characterisation of nanostructures. The expected outcome is a conceptually new means of interfacing functional nanoparticles with biomolecules, based on an innovative molecular network approach. This systems chemistry strategy breaks with the reductionist tradition that has characterised most research in chemistry for the last centuries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Mutualism abandonment in land plants and the origin of novel adaptations'.

assistant: **Objectives**

Evolutionary outcomes are constrained by lineage history. Episodes of drastic shifts in selection, as in cases of radical environmental change, often lead to the loss of traits that were once essential. While the loss of such traits may narrow niche breadth, it also creates opportunities for adaptive innovations. Whether trait losses are compensated by novel adaptations, and the extent to which similar outcomes evolved independently in unrelated lineages is largely unknown. In this project, I will investigate this problem by capitalizing on the recurrent loss of mutualism in land plants. Mutualism with soil microorganisms is ancestral in land plants, and provides plants with facilitated access to nutrients. Instances of secondary loss of mutualism are often linked to novel resource acquisition strategies, such as carnivory or parasitism. Some lineages, however, including vascular and non-vascular plants, have not undergone drastic niche shifts, and yet have largely diversified across the ecological space over time after losing mutualism. In this project, I will use comparative genomics and experimental approaches to test the hypothesis that mutualism abandonment was associated with adaptive genetic changes that compensated for the loss of mutualism. To determine whether the loss of mutualism operated as a source of selection on functions formerly facilitated by the mutualistic association, I will identify gene family expansions and genomic signatures of adaptive evolution that preceded and followed mutualism abandonment. I will then experimentally test this hypothesis in a comparative framework using closely related mutualists and non-mutualists of the liverwort genus Marchantia in conditions expected to differentially affect fitness according to mutualism status. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Smart Bio Adhesives for the Wood Industry Powered by Machine Learning' (2014-2020).

assistant: **Innovation**

There is currently no scalable, sustainable and non-toxic adhesive for the engineered wood industry. Manufacturers are having trouble to cope with more restrictive regulations (EU REACH, EPA) on formaldehyde-based adhesives for engineered wood products. Some manufacturers are experiencing around 15% productivity loss due to recent regulation tightening. Current adhesives are toxic to humans and have been connected to health problems (i.e. cancer), and new bio-based adhesives such as soy or lignin are not available in large quantities, are too slow to react in the press and too expensiveAt Materialize.X, we have developed a biologically based adhesive that works within an industrial environment and is produced from an alternative feedstock, compliant with current regulations. On top of that, we offer a support software for optimization of production.Our software and hardware are tightly interconnected: by modelling the manufacturing process, we can integrate our adhesive into the production line much faster and cheaper than with current trial and error methods.Our company was founded in December 2016, and our team of 5 members has been able to successfully produce industrial-grade wood engineered pressed wood boards. To fund our innovation development and go to market we have already raised 350.000€ from business angels and are now closing a 450.000€ investment round.The adhesives market is valued at €50 billion/year and the engineered wood market at €250 billion euro/year (in 7 EU countries it adds to €20 billion). Our business model is based on dual revenue streams: SaaS fees for the software and a license fee for the use of our proprietary adhesive (UK patented, PCT to be submitted in May 2018).We expect Materialize.X to become the main bio-based adhesive in the EU an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modelling and optimal design of ceramic structures with defects and imperfect interfaces' in the context of a Seventh Framework call.

assistant: **Objectives**

Ceramic industry is broadly developed in Europe and the current investment is estimated at € 26 billion. With its € 9,2 billion segment, Italy is a leader country in the production of traditional ceramics, while France, UK and Germany are driving countries for advanced ceramics, growing at 21% per year.Advanced ceramics are crucial for new technologies and nano-tech applications addressed to thermo-mechanical and bio-medical applications, while traditional ceramics have a worldwide market and have been suggested as materials minimizing the impact on the environment (when compared to other finishing materials).It may seem surprising that the strong industrial production of ceramic components is still based on empirically engineered processes, often poorly understood and difficult to control (Ewsuk, 1997). Consequently, there is a relatively large production of rejects and still broad margins for further process optimization. To this purpose, in-depth scientific understanding of the production processing is required, in order to reduce costs of ceramic component design and manufacturing and to produce ceramic components more reproducibly with improved performance and reliability. In particular, forming by powder compaction, binder burnout and sintering are the most sensibleprocesses (Reed, 1995; Rahaman, 2006).The main aim of the research project is to develop novel advanced ceramic products in close collaboration between academic and industrial partners which will be directly oriented to industrial and social needs. The goal will be achieved by(i)  improvement of the powder compaction and ceramic production process;(ii) development of novel advanced ceramic multifunctional materials and structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms of Multimorbidity – from Populations to Cells', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The overarching goal of my proposal is to deliver multimorbidity research that challenges and re-designs current thinking by combining agnostic, i.e. hypothesis-free discovery approaches with targeted hypothesis testing, bespoke experimental follow-up and validation. My proposal is to consider and integrate data across all diseases in diverse populations and at different life stages with focused clinical challenges and in-depth molecular investigations. By building and leading a team that delivers data-driven, solution-oriented multimorbidity science, I will address the following synergistic objectives structured to deliver my 3 main aims: 1) systematically map disease co-occurrence and estimate the prognostic impact of having multiple diseases, 2) accelerate early detection by identifying those at risk of developing disease clusters with the highest prognostic impact, and 3) enable precision prevention by understanding the underlying molecular mechanisms, i.e. shared causes driving the development of multiple diseases using multi-omic approaches at single-cell resolution and across the whole spectrum of common and rare diseases. The data opportunities and methods brought together to deliver this work reflect the reality of the ethnic and pathological diversity present in modern society with profound inequalities and thereby enable translatable solutions to clinical challenges that matter globally. The agnostic investigations of this proposal will identify and map previously unsuspected connections across diseases, organs and pathologies; a fundamentally different, data-driven computational approach that is complemented by scientifically prioritised, pre-specified investigations, and enables their parallel pursuit through the results it generates. I have provided scient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High-Precision Continuous Polar Borehole Temperature Monitoring System', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Earth’s climate system is experiencing an accelerating energy imbalance, with unprecedented heat accumulation driving rapid transformations across the ocean, land, cryosphere, and atmosphere. Despite the critical need for high-precision subsurface ice and soil temperature measurements—to assess land energy storage1, reconstruct past climate evolution2,3, refine ice models4, and determine permafrost stability5 — existing solutions are either insufficiently precise, prohibitively expensive, or incapable of long-term operation in extreme environments.Based on my ERC SPACE research, we started to develop HIP-Bore, a system that delivers unmatched milli-kelvin long-term precision, operates reliably in the harshest conditions, and transmits long-term subsurface temperature data with minimal maintenance. No comparable solution exists today. By bridging a key technological gap, HIP-Bore is set to revolutionize environmental monitoring and advance climate science. Its ability to capture transient subsurface thermal data in previously unmonitored regions will unlock new insights into ice sheet stability, permafrost response to global warming, and the planet’s shifting energy balance. To bring HIP-Bore from research to real-world application, we seek funding to finalize development, assess market potential, and define a commercialization strategy. This project will drive technology transfer, positioning HIP-Bore for deployment. With its scalable, cost-effective design, HIP-Bore has strong market potential across research institutions, government agencies, and industries focused on environmental and infrastructure risk assessment. By delivering unprecedented insights into subsurface temperature changes, HIP-Bore can set a new standard in monitoring and play a pivotal role in mi