RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enteric Bioelectronics for Sensing and Stimulating the CNS' under Horizon Europe.

assistant: **Concept**

Therapies for neurological disorders often involve deeply invasive brain operations or implants. A largely overlooked aspect of these conditions is the high comorbidity of GI-related disorders. Although the top-down relationship between the brain and peripheral organs has dominated the field, it’s now clear that activity of peripheral organs, in particular GI innervation – the enteric nervous system (ENS) – not only influences brain activity, but also paces and regulates it. Indeed, recent studies have shown the bidirectional relationship between gut homeostasis and neurological function in disorders such as epilepsy, Alzheimer’s, and Parkinson’s.EnterBio will adapt bioelectronic tools developed over the past decades for application in the CNS for sensing and stimulating the ENS, and thereby sensing and stimulating the CNS. The team comprises world-leading expertise in organic and graphene bioelectronics, drug delivery, in vitro/animal models of neurodegenerative disorders, and molecular/ cellular physiology of the PNS. We propose to turn this expertise toward the ENS to develop a platform for elucidation, prediction, and control of CNS function. Objectives are to:– Develop bioelectronic sensors, stim. electrodes, and drug deliv. targeting ENS and adapted for implantation in the gut – Elucidate ENS control of CNS using high-res sensing signals in vivo– Demonstrate control & eventual therapy for CNS disorders without highly invasive implantsEnterBio proposes to build on new, cutting-edge directions (organic/carbon-based bioelectronics and the gut-brain axis) to disrupt the field of CNS sensing/neuromodulation as technology to utilize ENS activity as an entry point to brain (dys)function is lacking. “Entering the bio” through the gut will be exactly this disruptor. EnterB
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Social organization of colonies in the ant proformica longiseta - a study based on microsatellite markers' in the context of a Fourth Framework call.

assistant: **Objectives**

The program is based on the study of the kinship relations that exist among members of a polygyny society, using microsatellites markers. These markers are a powerful molecular tool because of its degree of variability. Due to that the first objective is the isolation and characterization of the microsatellites in the species Proformica longiseta. This study would be carried out in the host institution, Department of Genetics, University of Uppsala. There we would learn the techniques and method necessary for it. The obtaining of samples would occur in Sierra Nevada (Granada-Spain). There we would take up polygyny nests and the ones that have been make up by budding from the former. We expect to know: genetic relatedness among coexisting queens and among workers, percentage of offspring of each queen Occurrence of haploid males. Percentage of males produced by female and by workers. The composition of the founddress group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Information processing in distal dendrites of neocortical layer 5 pyramidal neurons' (CHANNELRHODOPSIN).

assistant: **Innovation**

The aim of the current proposal is to investigate how synaptic inputs that innervate the distal dendrites of central neurons are integrated to form a neuronal output. The distal dendritic tree is the dendritic compartment furthest away from the action potential initiation zone. In the neocortex ascending afferent and intra-cortical information converges in neocortical layer 1 suggesting a prominent functional role, however only the most distal apical dendrites of layer 5 pyramidal neurons enter layer 1. We hypothesise that synaptic inputs are locally integrated at distal dendritic sites, perhaps in individual dendritic branches, leading to the generation of dendritic spikes as an output of compartmentalised integration. This hypothesis has until now been difficult to test experimentally as such distal dendrites are not amenable to direct electrical recording techniques. We plan to explore if these structures are capable of generating regenerative spike activity by remotely exciting individual branches of the distal apical dendritic tree using light-activated ion channels expressed in neocortical pyramidal neurons and measuring electrical activity at accessible nearby large calibre apical dendritic trunk sites and the soma. The use of light-activated channels to excite neurons is at the cutting edge of neuroscience research. Our plan is to use these channels to excite individual dendritic elements; a proposal that will require a multidisciplinary approach utilizing molecular, microscopy and electrophysiological approaches in an attempt to unravel the integrative operations of central neurons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Lensless label-free nanoscopy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Optical nanoscopy has changed the “seeing is believing” paradigm. This was achieved within a limited field of view (FOV~100µm2) and required fluorescent markers. Large-FOV high-throughput live unimpaired cell imaging is crucial for biology and biomedicine. Hence, improving the space bandwidth product (SBP) using time-consuming scanning stitching is not a good solution. Lensless holographic microscopy (LHM) inherently bypasses FOV limitations by using full sensor-size hologram reconstruction for label-free object information retrieval. Its major limitation, not yet addressed, is its low lateral (~1µm) and axial (~3µm) resolution. I will overcome this fundamental problem by pioneering deep UV (DUV) lensless holotomographic nanoscopy (LHN) as a simple and compact device easily operated inside the cell chamber or outside the laboratory (in contrast to lens-based systems). Owing to DNA damage, DUV is used to sterilize and never image bio-samples. This paradigm will be shifted to provide a breakthrough 10 giga pixel SBP via a low-dose DUV optical-elements-free (no cost, no radiation loss) lensless setup with a worlds-first full-angle tomographic scenario, numerical aperture > 1, and a new class of reconstruction algorithms to decrease the effective pixel (to 100 nm) and remove background noise. I will use LHN to enable the discovery of a new mechanistic understanding of extracellular vesicles expression and intake within large live cell cultures with single-vesicle resolution. EVs, nanosized lipid spheres released by virtually every cell type, are currently emerging as novel disease biomarkers and drug nanovehicles. LHN is a new research field that inherently makes this a high-risk project, but the potential gains are also high as a new era of simple ultrahigh SBP nanoimaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Role of nitric oxide in the control of renal function and renin secretion in the kidney - a transgenic approach'.

assistant: **Innovation**

Nitric Oxide (NO) plays an important role in the renal, cardiovascular, nervous and immune systems (reviewed by Reid, I. 1994). The presence of high concentrations of Type I nitric oxide synthase (NOS-I) has been demonstrated in the macula densa cells of the kidney. The objectives of this research project are to examine the role of NO expressed in the macula densa cells in renin secretion and renal function. The aim of this project is to use gene targeting and transgenic techniques established at the CGR in Edinburgh to mark and isolate NOS-I expressing macula densa cells, and generate conditionally immortalised cell lines using the H-2Kb -tsA58 transgenic mouse (Jat, P.S. et al., 1991). Using the conditionally immortal cell lines generated, the role of NO in the control of (i) renin secretion from the juxtaglomerular cells (JG), (ii) renal blood flow, (iii) glomerular filtration rate, (iv) tubuloglomerular feedback and (v) renal sodium excretion will be examined. The generation of these conditionally immortal cell lines will be of immense use to the further understanding of the renin angiotensin system, renal function, hypertension and cardiovascular research. References Jat, P. S., Noble, M. D., Ataliotis, P., Tanaka, Y., Yannoutsos, N., Larsen, L., Kioussis, D. (1991) Direct derivation of conditionally immortal cell lines from an H-2Kb -tsA58 transgenic mouse. Proc. Natl. Acad. Sci USA 88: 5096-5100. Reid, I.A. (1994) Role of Nitric Oxide in the regulation of renin and vasopressin secretion. Frontiers in Neuroendocrinology 15: 351-383.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pro- and Re-active cognitive control' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Keeping our behavior adapted to an ever changing environment requires that we constantly adjust information processing. Such adaptation is often considered to require control processes. Adaptive mechanisms can react to an encountered challenge in the environment (reactive control), or can anticipate such potential problems in order to avoid them (proactive control ). The goals of the present project are to better 1) characterize the interplay between pro and reactive control, 2) understand how such control mechanisms are recruited and 3) describe how they alter information processing to optimize behavior. Experimental psychology experiments inducing cognitive conflict (for example the Stroop task), will be used, augmented with several psychophysiological measures, such as High Resolution EEG and Magnetoencephalography (MEG), Transcranial Magnetic Stimulation (TMS) and fMRI. One current critical question is to sort out behavioral adaptation effect due to control, from the ones independent of control. One original aspect of this project will be to compare spontaneous behavioral adaptation to situations in which control is explicitly recruited. Second, subliminal incorrect response activation will be tracked thanks to electromyographic recording. EEG/MEG recordings, coupled with appropriate topographic and source localization techniques, will reveal the precise spatio-temporal flow of cognitive control. With TMS, thanks to a NeuroNavigation device, it will be possible to test this spatio-temporal flow, by transiently interrupting the normal information processing of delimited brain areas. One technical challenge of this project will be to record and detect subliminal incorrect muscular activations during fMRI acquisition. The possibility to detect such incorrect activation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A data analytics, decision support and circular economy – based multi-layer optimisation platform towards a holistic energy efficiency, fuel consumption and emissions management of vessels' (SmartShip) targeting Horizon 2020.

assistant: **Abstract**

SmartShip aims to bring together Information and Communication Technologies (ICT) of focused Universities, Research Institutions and Companies oriented into the maritime sector in order to build a holistic integrated ICT-based framework for the sustainable, individualized and completely automated energy management of ships. To accomplish this, it will take advantage of all the know-how that the consortium brings to the project referring to ICT technologies such as Data Analytics, IoT exploitation, DSS use, visualization tools, optimization algorithms and tools and Circular Economy approach methods. Smartship aims to offer a multi-layer optimization in the fields of fuel consumption, energy efficiency and emissions control management, in full respect to the implementation of the requirements of maritime sector regulations and taking into account applications of circular economy concepts in the maritime as well. Knowledge exchange between the partners that are already involved in the maritime sector, the ICT technology industry partners and the academia partners is one of the major Smartship’s objectives and will be materialised through corresponding secondments during the whole project’s timeplan. These synergies aim to build stronger collaboration relationships between the partners with respect to their future exploitation beyond Smartship project. Summing up Smartship will capitalise on available COTS technologies and will deliver an ICT & IoT-enabled holistic cloud-based maritime performance & monitoring system, for the entire lifecycle of a ship, aimed to optimise energy efficiency, emissions reduction and fuel consumption, whist introducing circular economy concepts in the maritime field.


**Keywords:** Energy efficiency and fuel consumption management, maritime, v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Acoustofluidic thin-film actuated chip for exosome separation from blood' (AcouSome).

assistant: **Concept**

AcouSome is a consortium stemming from the ongoing EIC-FET Open BioWings project, and consists of four of the BioWings projectpartners (AcouSort AB, DTU, Lund University and Day One Srl). AcouSome has the ambition to build on the disruptive technology ofthin film actuated acoustofluidics developed in BioWings. The results obtained in BioWings will be combined with a polymeracoustofluidics technology developed in the ongoing Eurostars AcouPlast project to fabricate a polymer-based microfluidic chip forseparating and enriching exosomes from blood for use in the next generation of point-of-care diagnostics.Exosomes are nano-sized extracellular vesicles that are released by a significant number of different cell types. They are considered animportant biomarker, with high diagnostic potential in a wide range of diseases, including different kinds of cancer (glioblastoma,melanoma, prostate cancer and many others), hepatitis, kidney, cardiovascular and liver diseases. Therefore, there is an increasinginterest in exosomes as a powerful diagnostic tool. Having the opportunity to isolate and analyze exosomes from a routine blood testis crucial for early detection of a wide range of diseases.In the AcouSome chip exosomes will be separated and enriched from blood by combining two steps already developed by LundUniversity and AcouSort. First plasma will be separated from blood by flowing the blood through a microfluidic channel, pushing thecells towards the centerline of the channel using ultrasoundand and subsequently splitting the cell and plasma flows. Exosomes willthen be trapped and enriched from the plasma flow using a localized acoustic field. The acoustofluidic chip will be driven usingthin-film actuators as invented together with DTU in the BioWings project. The exosome sep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'REGENERATION OF NATIVE FOREST STANDS FOR TIMBER PRODUCTION AND ENVIRONMENTAL VALUE' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Background : There is a need for practical implementation of Helsinki resolution no. 1 and 2. ('General Guidelines for the sustainable Management of Forests in Europe' and 'General Guidelines for the Conservation of Biodiversity of European Forests'). The objectives are : Development of silvicultural prescriptions for biodiversity, gene-conservation,sustainability and environment friendliness in practical forest management.Short description of the project :The project will develop forest regeneration systems to achieve realistic targets both for production and biodiversity for stands of native tree species. It includes the development of regional models of species composition. The development of practical silviculture prescriptions will use experimental manipulations of plots in traditionally managed old stands
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ensuring dependability of p2p applications at architectural level', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The main objective of the P2P_Architect project is to enable software developing organisations to build dependable software systems conforming to a peer-to-peer (P2P) architecture. This is proposed to be achieved by defining and implementing a tool supported methodology for ensuring at architectural level that dependability requirements for software systems conforming to a P2P architecture are met and validate it in real life applications from the operation of typical enterprise (sub-) systems in a peer-to-peer computing environment. The project will work towards tailoring a process for ensuring that dependability requirements of P2P applications are met at the architecture level based on an advanced technical solution, supported and validated by user feedback. Results of the project will be suitably packaged in an offer comprising both software tools and specialist consultancy.OBJECTIVESPeer-to-peer (P2P) computing, promises a wide array of new capabilities & applications: dynamic, distributed search, distributed content storage & management, massively parallel & distributed processing and person-to-person communication. The project aims at developing methodology & tools for supporting architecture-based development ofP2P applications and ensuring at the architecture level that dependability requirements (availability, reliability, security, survivability, responsiveness) are met. Validation in specific critical domains for the media & consultancy services sectors & feedback from user groups will combine towards creating an attractive offer for the industry comprising of methodology & tools (for ensuring dependability of P2P applications at architecture level) & consultancy services.DESCRIPTION OF WORKThe project workplan is deployed to ensure: co-ordination of all act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Contested port cities: a global geography of community conflicts', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Many contemporary ports are threatening the very communities that previously nurtured them. This research proposal tackles the emerging phenomenon of socio-spatial conflicts arising in port cities, and argues for a new critical approach that centres the experiences and responses of those contesting the making of global ports.Over 90% of the world’s trade is carried by sea, with forecasts for further growth. The expansion of increasingly privatised and corporatised port infrastructure is creating a clash of interests between multi-scalar markets and globalised value chains on the one hand, and inhabitants of the port hinterland on the other. The making of global ports is thus transformed into an urgent societal issue, which demands a social scientific approach that acknowledges the interconnected nature of localised conflicts. Ports are not just global trade hubs, but are indispensable cogs in the complex and sometimes “predatory” machinery of the global supply chain. Increasing demand for space and water as well as greater air, soil, sonic and water pollution are only some of the reasons for the social contestations that manifest. This holds new theoretical and practical implications for social sciences, fundamental for conceiving resilient and inclusive futures for port cities away from economic disciplinary perspectives.By focusing on the new socio-spatial tensions in the inhabited fringes surrounding harbours, I expect to reveal logistics-driven mechanisms of rupture that impact people and places in the making of global ports. I will analyse two specific paradigmatic cases – Piraeus and Valencia – using ethnographic methods to understand the specific local contexts impacted by this globalised infrastructure. This project also entails the development of an online plat