RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Stress-Immune Systems interactions'.

assistant: **Objectives**

Although associations between psychosocial stress and health outcomes have now been carefully documented for several diseases, the mechanisms by which stress specifically influence disease susceptibility, activity and outcome are poorly understood. This proposal focus on the role of stress hormones in the regulation of pro-inflammatory and anti-inflammatory cytokine production for 2 major reasons: (1) the balance of pro-inflammatory/ T helper (Th)1 versus anti-inflammatory/Th2 cytokine production is critically skewed, one way or the other, in several common human diseases such as infections, allergy, autoimmunity and atherosclerosis; (2) hyperactivity or hypoactivity of the stress system influence the onset and/or the course of the above-mentioned diseases. Thus, better understanding of the stress system regulation of Th1, Th2 and pro-/anti-inflammatory cytokine responses may provide critical insights into mechanisms underlying a variety of common human immune-related diseases.Over the past decade others and we have shown that stress hormones inhibit the production of Th1 cytokines but stimulate the production of Th2 cytokines. Taking into consideration the above-mentioned important clinical implications, further studies in this direction are warranted.The major objectives of this grant application are:(1) further extend the work of the applicant in this field;(2) support the reintegration of the applicant and transfer of knowledge acquired in the USA;(3) complement a Marie Curie Chair proposal of the applicant;(4) support the continued development of an existing multidisciplinary organizational structure.The research project will focus on:(1) effect of stress hormones on the production of newly described Th1 and Th2 cytokines;(2) neural-immune interact ions at the vasc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New colour laser marketing on polymers (plastics and textiles)' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The aim of this project is to develop an improvement process of plastic parts and textile products in a very flexible way. This new process will be based on the marketing technology. But the major drawbacks linked to laser marketing are that it can not give colors, it is limited to black marking.The main goals of the proposed project are:* unlimited inscription and decotation possibilities through:* unlimited number of colors per support,* all support color allows,* no limitation concerning motifs to realize.- Conservation of the high wear resistance of the laser marking and other related advantages.- The same equipment to make color laser marking on textile or plastics. This project will answer the needs of industrial in the textile and plastic industries as it will allow them to have a resistant colour marking. It is of main importance to identify the product better and to protect them from counterfeiting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative technological, organisational and social solutions for FAIRer dairy and fruit and vegetable value CHAINs' (FAIRCHAIN).

assistant: **Innovation**

FAIRCHAIN addresses the growing need for a significant transformation of current food systems by developing competitive intermediate food chain alternatives adapted to small and mid-sized actors. FAIRCHAIN specifically aims to: -Foster the emergence of innovative intermediate food value chains that support the scaling-up of small and mid-sized actors facing unsustainable conventional dominant agri-food system. This requires to specific technological, organisational and social innovations as well as regulatory and policy adaptations to widely deliver food in a fair and sustainable way. -Inspire and encourage larger actors to down-scale conventional food value chains and better address the growing need of consumers to consume local high quality and safe products. The emergence of intermediate food value chains should put pressure on dominant actors, forcing them to align with best practices in terms of offering opportunities to local suppliers and ensuring an equitable distribution of costs and benefits.The main goal of FAIRCHAIN is to test, pilot and demonstrate recently developed technological, organisational and social innovations, realising a shift up to TRL7 and enabling small and mid-sized actors to scale-up and expand the production of affordable nutritious food in competitive intermediate food value chains. FAIRCHAIN will address the dairy and fruit&vegetable sectors, which hold a strategic economic position in Europe. Both are prone to integrate a large variety of innovations, correspond to an increasing consumer demand for nutritious and healthy food and need to meet the challenge of sustainably delivering perishable commodities to consumers.FAIRCHAIN will consider the entire value chain. More focus is given to postharvest steps rather than the production step i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of comprehensive in-line quality control system for printed circuit board assemblies (MICROSCAN)' (MICROSCAN), addressing dissemination and exploitation.

assistant: **Impact**

Microscan will produce a powerful tool in the total quality control of PCB assemblies, which can also reduce the cost of the manufacturing process and will provide an impetus to the PCB industry in Europe. It will greatly improve the employment prospects of the region as well as improving the quality of life, initially for Europe but then worldwide. In addition to the above this project will aid in the introduction of Lead free solder by developing the NDT techniques on a selection of lead free samples an d provide genuine environmental benefits. European Parliament Directive 2002/95/EC on the restriction of the use of certain hazardous substances in electrical and electronic equipment and Directive 2002/96EC on waste electrical and electronic equipment. T he project will complete this by developing a Non-Destructive system, which can provide full coverage of all defects in PCB manufacturing. Assembled PCBs can suffer from many defects. It is highly beneficial for these defects to be detected at the product ion stage, as failure in the field can result in massive financial costs tor the manufacturer which is then passed on to the consumer. There is no existing non-destructive testing (NDT) system, which incorporates all of the available techniques to form an integrated in-line quality control system. This gap in the market means that flaws will be missed and adds to the financial burden of the manufacturers and the whole European community. There are currently specific limitations to the NDT techniques and e quipment, which prevent them being combined in an integrated system, which can be operated in-line. The Microscan project will overcome the current limitations and develop new techniques for X-ray detection, develop novel improvements for AOI and innovati ve and nov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'NOVEL AERONAUTICAL MULTIFUNCTIONAL COMPOSITE STRUCTURES WITH BULK ELECTRICAL CONDUCTIVITY AND SELF-SENSING CAPABILITIES'.

assistant: **Objectives**

Aircraft structures appear to be strategic components to be manufactured in composite materials for reducing weight, although new questions regarding electrical conductivity have arisen such as static discharge, electrical bonding and grounding, interference shielding and current return through the structure.These functions can be met by the use of technologies based on nanocomposites, which indeed combine mechanical properties, electrical and thermal conductivity.Based on the needs to provide advanced concepts and technologies for increased and optimised use of light-weight composite smart materials, the main objective of ELECTRICAL is the development of novel multifunctional composite structures with bulk electrical conductivity and self-sensing capabilities.The project will investigate and develop alternative emerging methods to manufacture nanoreinforced carbon based composites compatible with current industrial manufacturing processes of composites. The main goals will be:*Development of innovative technologies to convert nanofillers into engineered multifunctional preforms, prepregs, buckypapers, etc.., for further use in CFRP structures. CNTs bulk doped resins are also to be considered as the main base-line.*Manufacture, characterisation and test CFRP based materials with such multifunctional engineered nanostructures. Liquid moulding technologies will be considered, althoug autoclave technology will also be considered as the second alternative. The three main functionalities will be:*Electrical conductivity of aeronautical composite structures to meet requirements regarding static discharge, electrical bonding and grounding, etc.*Monitoring and optimisation of CFRP curing process by Dielectric Mapping.*Quality assurance of final component (delaminations, etc) by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reversible Covalently Binding PROTACs Technology for Protein Degradation in Cancer Therapy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Today's challenge for modern medicine is the development of tools that can selectively target cancer cells over healthy cells. Acute myeloid leukemia (AML) is an aggressive blood cancer of the myeloid cells causing bone marrow failure. Drug development research uses small molecules to inhibit the activity of proteins promoting cell proliferation. The higher concentrations of drug required for efficient inhibition often lead to off-target effects. Recent years, proteolysis targeting chimeras (PROTACs) technique receives much attention for therapeutic intervention by degradation of disease-causing proteins. However, the requirements of PROTACs such as high affinity and specificity ligands, poor stability, cell permeability, lack of cell specificity limit the broader utility of this technique. Here, we propose a novel rational design and synthesis of reversible covalently binding PROTACs (RECOBIN-PROTACs) based on the proximity labeling. A RECOBIN-PROTAC molecule consists of target protein ligand, E3 ligase ligand and a chemoselective functional group connected through flexible linkers. The chemoselective functional group forms reversible covalent modification with proximal Lys residue of BET protein or E3 ligase. This proximity labeling enhances the binding affinity of the ligands to the targets, stabilizing protein-protein interactions in ternary complex formation. The library of RT53 based RECOBIN-PROTACs will be tested on AML cell lines to find most efficient degraders. Also, the chemoselective group masked by self-immolative linker connects with enzyme-labile group and cysteine reactive handle. The most efficient RT53 based RECOBIN-PROTACs will be conjugated site-selectively to cysteine antibody to generate stable RECOBIN-PROTAC-Antibody Conjugates. These conjugates s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SoluTions foR mItiGatinG climate-induced hEalth tReaths' in the context of a Horizon Europe call.

assistant: **Objectives**

In spite of the ambitious mitigation efforts set out globally and addressed by initiatives of the European Commission, climate change is under way and intensifying (IPCC, 2021). According to WHO estimates, the direct damage by impacts of climate change on human health is between 1.7 and 4 billion ? by 2030. The aim and ambition of TRIGGER are to deepen current understanding of the linkage between climate, health and ecosystems (exposome framework) and to use this knowledge to advance society uptake at personal and policy level. To meet the ambition, TRIGGER will commit an interdisciplinary consortium of 22 partners in 15 countries that will develop an outreaching clinical study composed by a multi-dimensional approach that capitalizes also on existing retrospective studies and will build an international climate service for global health protection, in line with COPERNICUS initiatives. TRIGGER strategy is grounded on three pillars: i) trans-disciplinary investigations to build up systemic knowledge ii) integration and usability of research results and iii) development of practical know-how and workable tools to monitor, predict and mitigate risks for human health connected to climate change. The proposal is designed around the creation of 5 newly conceived Climate-Health Connection Labs in Europe that engage citizens, practitioners and policy-makers in a co-creation process. The approach will target areas exposed to adverse impacts of climate change, such as increased heat waves, air pollution and droughts, and will address key health issues such as cardio-vascular diseases, respiratory diseases and UV exposure. By overcoming heterogeneous technological and methodological challenges, TRIGGER will provide exploitable tools to strengthen surveillance mechanisms and risk a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Unbalanced Wnt signalling in AD: a DNA methylation effect'.

assistant: **Innovation**

Growing evidence suggests that unbalanced Wnt signalling contributes to early stages of Alzheimer´s Disease (AD). mRNA levels of the Wnt antagonist Dikkoff1 (Dkk1) are increased in AD brains and by Amyloid-ß (Aß) in vitro. Importantly, suppression of Dkk1 activity protects synapses from Aß. Genome-Wide Association Studies also provide evidence for deficient Wnt signalling in AD. The host laboratory has recently demonstrated that Dkk1 induced expression in the adult hippocampus leads to synapse loss and cognitive impairment; defects that can be restored by Wnt signalling reactivation. My preliminary results demonstrate that mRNA levels of several Wnt components (Wnts, their receptors and antagonists) are affected in a transgenic mouse model of familial AD, suggesting a general downregulation in Wnt signalling. These findings raise two main questions. Is aberrant expression of Wnt components an early event in AD? What mechanisms lead to aberrant Wnt component expression in AD? Given that Wnt signalling is crucial for synapse maintenance, and that my preliminary results suggest a coordinated downregulation of the Wnt pathway in AD, I will examine the role of DNA methylation at Wnt component genes in AD and how this affects synapse integrity.  The potential role of DNA methylation is supported by: i) AD patients and mouse models exhibit global DNA hypomethylation and gene-specific DNA hypermethylation, ii) DNA methylation at promoters leads to gene repression, but intragenic methylation can enhance transcription, iii) Wnt components contain CpG islands at their promoters and/or intragenic regions, and iv) some Wnt components are regulated by DNA methylation in cancer. My work will define the role of epigenetic regulation of Wnt components under physiological conditions and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enhanced, Ubiquitous, and Dependable Broadband Access using MESH Networks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

EU-MESH's goal is to develop, evaluate, and trial a system of software modules for building dependable multi-radio multi-channel mesh networks with QoS support that provide ubiquitous and ultra-high speed broadband access. The system will be based on a converged infrastructure that uses a wireless mesh network to aggregate the capacity from both subscriber broadband access lines and provider fixed broadband links to form a virtual capacity pool, and provide access to this capacity pool for both stationary and mobile users. It will support low operation and management costs, through novel configuration and management procedures that achieve efficient usage of both the wireless spectrum and fixed broadband access lines. This will increase the competitiveness of existing providers, lower the barrier for small enterprises to enter the mobile broadband access market, and enable innovative services.<br/>Existing mesh systems do not achieve efficient resource utilization, have sub-optimal channel and power control that prohibits large-scale deployment, and lack a comprehensive security solution combining proactive and reactive mechanisms.<br/>To address the above, EU-MESH's objectives are to develop <br/>-algorithms that combine channel access with power and channel control to reduce interference,<br/>-QoS and opportunistic routing algorithms to support scalable end-to-end QoS and efficient usage of the virtual capacity pool,<br/>-location-aware automated (re-)configuration procedures that adapt to varying network conditions to provide robust connectivity,<br/>-lightweight application layer procedures for seamless mobility over heterogeneous and multi-operator mesh networks,<br/>-secure routing and handover in single and multi-operator mesh networks, and intrusion detection an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Social networks and natural selection in changing societies'.

assistant: **Innovation**

Social interactions can improve support, resources and protection, but can also increase disease, stress and conflict. Consequently, for group-living species inc. humans, traits as diverse as personality, residence patterns, family-living and disease resistance all evolve in response to pros and cons of sociality. However, the direct links between sociality, health, fitness outcomes and ultimately natural selection are not well-known. KinSocieties reveals, for the first time, the benefits and costs of sociality accrued by individuals and whole societies in two complementary study species - humans and Asian elephants - facing current drastic changes in social structures due to break-down of kin networks. I use rare longitudinal data and two previously unstudied natural experiments to investigate effects of translocation to new social environments, addressed in 6 WPs:How have human social networks transformed with the modernisation of societies and associated with reproduction, cause of death and lifespan at different times?How does population structuring in humans affect reproduction, cause of death and lifespan?How does population structuring in Asian elephants affect reproduction, cause of death and lifespan?How is translocation to new area with/without kin or friends in humans related to subsequent integration, social networks, reproduction, lifespan and cause of death?How is translocation to new working units with or without kin, friends or social group in Asian elephants associated with stress, health, and friendship formation?Synthesize the costs & benefits of dynamic social structures in a modelling frameworkThis research boldly combines approaches from social sciences, conservation, evolutionary demography and biology. The results have key theoretical and practic