RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrating breeding for IPM into the deployment landscape for wheat, potatoes and grain legumes' (IPMorama).

assistant: **Concept**

IPMorama will improve the state of the art in variety-centric Integrated Pest Management (IPM) for important diseases in the wheat (rust pathogens), potatoes (blight) and the grain legumes soybean, pea (broomrape) and white lupin (anthracnose). IPMorama seeks to develop the infrastructure for a whole “practice ecosystem”, whereby the more efficient development of IPM-centric varieties is enabled, while at the same time developing tools and resources to efficiently exploit these in variety-centric IPM. The core innovation of IPMorama is to integrate knowledge of host resistance with the pathogen virulence landscape over space and time, to produce IPM tools (eg crowd source apps, vulnerability maps) and strategies, which will be validated at various scales and in conjunction with different agroecological practices. IPMorama will achieve these goals by enacting the following five components: 1] Understanding the genetic composition of varietal resistance in target crop/pest systems, and development of tools and resources to allow breeders to target the assembly of resistance components. 2] Understanding and mapping the landscape level distribution of the target pathogens/pests, especially in terms of their virulence against the available set of resistance and tolerance genes in varieties and breeding lines. 3] Developing specific integrated pest management practices for the optimal exploitation of pest and pathogen resistance in varieties on the basis of the first two components. 4] Developing the knowledge infrastructure for competent use of variety-centric IPM by actors across the variety-related value chain. 5] Understanding opportunities and barriers for scale-up of variety-centric IPM solutions.


**Keywords:** MAS (Marker Assisted Selection), GS (Genomic Selection) r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'APAC – the first targeted therapy for peripheral arterial occlusive disease.' (APAC-ON), addressing dissemination and exploitation.

assistant: **Impact**

There is a major unmet need for effective and safe therapies for advanced peripheral arterial occlusive disease (PAOD) due to the high cardiovascular mortality, morbidity, and amputation rates in these patients. Aplagon is developing the first vascular injury -targeting product (APAC) for the local treatment of advanced PAOD. PAOD is caused by fatty deposits in lower limb arteries (atherosclerosis) that become inflamed (thromboinflammation), resulting in blood coagulation (atherothrombosis). APAC uniquely targets these vessels, prevents further atherosclerosis and downregulates thromboinflammation, the main drivers of PAOD. Aplagon has completed preclinical proof-of-concept and toxicology studies and received a regulatory approval to enter clinical studies. Aplagon has an experienced, international team, and is supported by a renowned scientific advisory board. We are applying for EIC-funding to show the safety and efficacy of APAC in PAOD/CLI-patients, a major value inflection point.


**Keywords:** Critical limb ischemia,Health-related biotechnology,Bioproducts (products that are manufactured using,Pharmacology and pharmacy,cardiovascular disease,Peripheral artery disease,Engineering and technology,thrombosis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Using Topology To Revolutionize Atrial Tachycardia Treatment' (AT-TOP) under Horizon Europe.

assistant: **Objectives**

Atrial tachycardia (AT) is a prevalent form of supraventricular tachycardia that can have detrimental impacts on a person's health. The complexity of anatomical reentry patterns and unclear nomenclature hinders precise diagnosis of AT and makes optimal treatment challenging and error prone. Suboptimal treatment can result in severe outcomes such as heart failure, stroke, and pacemaker implantation due to overablation-induced atrial dysfunction. In this proposal, we introduce a diagnostic tool called Directed Graph Mapping (DGM), which offers a unique classification system based on clear and precise mathematical criteria using topological principles, allowing for the accurate diagnosis and differentiation of various types of AT. DGM can automatically analyze a given case of AT, providing consistent and reliable results, paving the way for the optimization of the ablation strategy. DGM can not only diagnose the current AT but also predict hidden slower ATs, which might appear depending on the chosen ablation target. By being able to predict the hidden ATs, we can revolutionize the treatment of ATs, as these hidden ATs can be treated already after the measurement of the first anatomical map. Therefore, our tool holds the potential to significantly expedite the ablation procedure. We propose to conduct a prospective study involving a minimum of 15 hospitals in Belgium that specialize in AT ablations to further validate the effectiveness and sustainability of our proposed solution while involving a broad range of electrophysiologists. We aim to publish our results in a high-impact journal. We secured the intellectual property rights of our proof-of-concept through two patents, and by discussing with electrophysiologists, we learned that their interest in DGM influences mappi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Development of a boryl radical-mediated H-atom transfer umpolung blueprint to make nucleophilic radicals behave as electrophilic species'.

assistant: **Objectives**

Aliphatic molecules are integral to every aspect of chemistry and radical chemistry has strong impact in their preparation. However, radical reactions are heavily influenced by the polarity of these species, which ultimately controls their reactivty profile.Most notably, standard alkyl radicals are nucleophilic and therefore do not react with electron rich aromatics and olefins. Electrophilic radicals display strong reactivity with these species but they are of limited synthetic value.This project seeks to address this challenge by developing an innovative approach for radical ""umpolung"". In particular, we will demonstrate the integration of photoredox catalysis and boryl radical-mediated H-atom transfer catalysis, as a unique blueprint for the activation of alpha,alpha-diborylated alkalnes. This will generate alpha,alpha-diborylated radicals that, owing to their strong electrophilic character, will (i) react with electron rich aromatics and olefins and then (ii) enable diverge functionalization. In this way we will overcome the fundamental issue that nucleophilic alkyl radicals do not react with electron rich olefins/aromatics. This reactivity will streamline the preparation of many high-value but difficult to make aliphatic products, will be used in late-stage functionalizations and will substantially expand the fields of photoredox catalysis and boryl radical chemistry.This research capitalizes on recent developments of the Leonori group that has experience in the design of methodologies based on both H-atom transfer and boryl radical reactivity. The completion of such an innovative and ambitious project at RWTH Aachen University will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Giovanni Tortelli's Orthographia and Greek studies in Xvth century Europe' to be submitted under Seventh Framework.

assistant: **Abstract**

This project aims to study the role of Giovanni Tortelli (1400c.-1466) and of his most important work (the Orthographia) in the promotion and dissemination of the study of Greek in Italy and in Europe in the fifteenth century. Friend of Lorenzo Valla, who dedicated to him the Elegantiae, Tortelli collaborated with Pope Nicholas V in founding the Vatican Library and supervised the search for Greek manuscripts and the work of many translators hired by the pope. His work, still largely unknown, represents a crucial cross-section of the role played in the dissemination of Greek culture at that time, when the knowledge of the Hellenic language in Italy and in Europe was still the preserve of a few. My research will provide the first systematic study of the Greek sources of his Orthographia, a bulky dictionary of Greek words transposed into Latin, an enciclopedic dictionary to be used for reading and commenting on the classics. In the ms. Vat. Lat. 1478, the manuscript revised by Tortelli himself, it consists in more than 3.000 words and in about 380 ff. (760 pages). This work was widely diffused in Europe. My project will set the Orthographia in its context, and show its role in the new wave of interest in the spread of Greek studies in the West Europe during the fifteenth century; I will also compare the data coming from the Orthographia with those coming from the study of a complete course of Greek held in Veneto region in the XV century and now preserved in two manuscripts at the Bodleian Library, Oxford. My project will result also in a database devoted to Greek grammars, lexica and school books available in Europe between 1396 and 1529, whose metadata will be linked with the Perseus project catalogue of Gregory Crane's group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Connections between core-mantle interaction and the geomagnetic field' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The Earth's magnetic field is generated by fluid flow at the Earth's metallic liquid outer core, in a process known as the geodynamo.Because of its current strength and mainly dipolar geometry, the geomagnetic field efficiently organizes the way energetic particles flow in the vicinity of the Earth. Those particles mainly originate from the solar wind and may occasionally and regionally reach the Earth's atmosphere. Were it not for the Earth's magnetic field, they would directly reach the atmosphere.The geomagnetic field however decays by a rate 10 times faster than the rate of free decay, and displays a large area of even faster-growing weakness (on a decade time-scale), known as the South Atlantic Anomaly, where more and more of those particles are to be found, increasing the danger for both manned space missions and satellites.Understanding the mechanisms responsible for this rapid evolution is both a practical issue - providing some input for space scientists to predict the future areas of dangers in the space environment - and a fundamental one - understanding the inner working of the geodynamo.The objectives of this research are more specifically to study the possible influence of core-mantle interactions- in defining the main characteristics of the current geomagnetic field,- in governing the evolution of the geomagnetic field.These goals will be achieved using an approach combining data analysis and numerical simulation. Such a combined approach has seldom been used so far, but is now finally accessible for extensive studies, thanks to the availability of more and more high quality geomagnetic and seismological observations, and of much more affordable dynamo numerical codes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Conference and course: human monitoring for genetic effects""' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Many methods are available for monitoring genetic damage induced. The A. Hollander Course will concentrate on the commonly measured biomarkers (chromosome aberrations; micronuclei; DNA), but others (p53 protein levels; metabolic genotypes) will also be addressed. Distinguished scientists from the fields of toxicology, molecular biology, cytogenesis and epidemiology will present and discuss the state-of-the-art knowledge and recent developments in human monitoring for biomarkers. Course will include both lectures and demonstrations. The organiser is planning to arrange the financial support to attract participants from ex-Eastern Block Countries. An enrolment of 30 students is planned. These students are expected to be primarily junior researchers and graduate students, although the course would also be open to the more senior investigator who wants to conduct regional dialogue and create the network in human monitoring.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'High Content Microanalytical Ramanomics for Ultraquantitative Phenotyping of Individual Stem Cells and Bioengineered Organoids'.

assistant: **Concept**

Human induced pluripotent stem (hiPS) cell-based organoids have recently emerged as a promising model system to recapitulate the structure and function of actual biological tissues and organs. These 3D self-organized multi-cellular tissue systems bridge the gap from cell to tissue/organ levels, providing bio-relevant model systems with foreseeable utility in drug discovery, regenerative medicine, and the study of disease pathogenesis, but the increased complexity and unique attributes of each system introduces new challenges in cell culture and experimental reproducibility. While organoids offer profound potential for applications in biological and biomedical research, their scientific value is limited by how closely they mimic the in vivo tissue systems they are intended to model. To achieve a successful organoid-based predictive model system, it is crucial to have a quantitative biochemical and structural analysis technique for single cells and organoids.   In UltraRamanomics, I will develop a robust quantitatively-calibrated bioanalytical platform for high content phenotypic profiling of individual stem cells and hiPS cell-derived organoids, to allow direct structural and quantitative compositional comparison of organoid models in absolute biochemical measurements, thereby addressing the currently unmet analytical need. The platform will be based on micro-Raman spectroscopy – enabling direct measurements of the absolute biochemical composition of single-cells and tissue organoids with unprecedented spatial resolution – to provide a novel analytical solution to the existing gap in stem cell organoid research. This proposal takes full advantage of recent advances in ultraquantitative micro-calibration technology I developed during my PhD, quantitative volumetric Raman
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Magnetic Nano Actuators for Quantitative Analysis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The MANAQA project is a multidisciplinary approach that combines innovative technologies emerging from different fields including nanotechnology, biochemistry, and nanorobotics. The strategy that will be exploited is based on a recently developed 5-DOF magnetic manipulation system combined with an atomic force microscope (AFM) system and functionalized magnetic nanowires. The fusion of these technologies has the potential to revolutionize many aspects of single-molecule manipulation and measurement. Information related to the structure and physical properties of macromolecules (i.e., proteins, polynucleotides) will be obtained. In a typical experiment, a molecule will be regiospecifically attached between a magnetic nanowire and the tip of an AFM cantilever. The extremely small footprint of the magnetic nanowire and the accuracy of a five degree-of-freedom magnetic manipulation system will allow high-resolution and stable force control on the molecule. The mechanical response of the molecule will be monitored using the AFM cantilever. Moreover, the system will be capable of measuring the electrical parameters of the nanowire-molecule hybrid. The success of this proposal will lead to long time-scale, low drift experiments that will provide invaluable insights on mechanisms governing conformational changes in single macromolecules by elucidating protein folding/unfolding/refolding trajectories at a low-force regime. This will contribute to the long-term vision of MANAQA of establishing a biomolecular measurement platform with extended capabilities. MANAQA opens new avenues in disciplines such as biochemistry, pharmacy, and biomedicine. The development of new miniaturized electronic devices within the scope of MANAQA project with single chemical entities integrated as thei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Resilience Enhancement through Multi-Hazard Recovery Analysis of Earthquake and Flood-Affected Infrastructure'.

assistant: **Innovation**

The increasing frequency and severity of multi-hazard events necessitate comprehensive frameworks to assess the compounding risks to infrastructure systems. Multi-hazard risks, particularly from independent hazards impacting the same infrastructure and communities simultaneously (or close in time), significantly affect the resilience of urban centers. Recent events, such as the flooding in Türkiye following the 2023 earthquake, demonstrate the compounded impacts on communities and infrastructure. These interactions are understudied despite their severity, particularly concerning infrastructure resilience and recovery. To address this gap, the RE-EnForce project introduces a novel computational framework to quantify multi-hazard risks in interconnected infrastructure systems, focusing on interactions between unrelated hazards that impact the same system. The project will also provide novel risk and resilience metrics for stakeholders, including government agencies, emergency managers, and the reinsurance industry. While adaptable to various infrastructure systems and hazard interactions, RE-EnForce prioritizes models to assess the risk and resilience of reinforced concrete building portfolios and transportation networks, accounting for impacts of earthquakes and floods occurring in the same region and within short timeframes. The key project outcomes include (a) consistent consequence scales to evaluate the functionality of individual RC buildings and building portfolios for hazard interactions, (b) similar scales to assess the functionality of bridges and transportation networks, and (c) a decision-making framework considering the system-level performance of interconnected infrastructure. By addressing the compounded effects of spatial and temporal hazard interactions,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Content Networks and Services for Home Users'.

assistant: **Concept**

The CONTENT Network of Excellence targets Content Delivery Networks for Home Users, as an integral part of Networked Audio-Visual Systems and Home Platforms.  CONTENT aims to build the European Research Area in this important communication topic by integrating a group of experts with the purpose of taking forward the state of the art and increasing European leadership in Content Networks. The overall goal of the CONTENT Network-of-Excellence is to integrate the research efforts of the members to address the technical challenges at the different system levels to enable easy-to-install and easy-to-use AV services in and between homes. In particular, the main technical objective will be to boost the potential of European Community Networking by improving Content Distribution infrastructures for the delivery of live (streaming) content and interactive stored content, and by integrating, in an open way, tools and mechanisms that would enable the curation of multimedia assets and their subsequent access for the benefit of the communities of users, producing a set of appropriate services for them, both in the context of the long tail" or applied to (re-purposed) assets created by traditional broadcasters. The joint programme of activities aims at the creation of a self-standing virtual centre of excellence that should result in developing the necessary means for achieving a durable integration of the research capacities. CONTENT will continue the idea initiated in E-NEXT of investing in the education of young researchers through the European Doctoral School of Advanced Topics In Networking (SATIN) to prepare the next generation of researchers for the European Research Area. CONTENT members draw considerable experience from the current FP-6 NoE E-NEXT, and will achieve these ob