RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bringing innovAtion by Scaling up nanoMATerials and Inks for printing' (BASMATI).

assistant: **Innovation**

The BASMATI project will address the development of active nanomaterial and electrochemical inks for printing technologies such as screen and inkjet printing. The ink formulations will be tested on a case study through printing of a thin film battery. The general objective of the project is to scale-up the ink formulations to pilot line ensuring large volume fabrication of new products with improved properties for printing application. Especially, the particles definition at nanometer size will be one key parameter for the compatibility in ink jet printing. Moreover, knowledge will also be generated on electrochemical inks formulation and additives used in order to stabilize the ink products. The concept of nanomaterials for printing application will be applied to flexible printed electronics and more specifically to printed batteries. These printed batteries are needed as power source at the closest part and the development of printed electronics so as to as to design an all-in-one product allowing better process ability in ink jet process for 3D design and 2D screen printing process.BASMATI will also provide a new source of nanomaterials for the formulation of conductive and electrochemical inks. These nanomaterials will be metallic particle (Ni, Cu, Al) that will be usable for numerous applications of printed electronic on flexible substrate. Another type of nanomaterials will be layered positive active material such as LiNi1/3Mn1/3Co1/3O2 (NMC) and olivine LiFePO4 (LFP). The know-how level reached in BASMATI by research groups and transfer and up-scale to pilots (TRL 6) at SMEs and industry facilities will pave the way for future industrialization of inks formulations production for mass markets such as printed electronics. The compatible formulations in high throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PoC in-office device for identifying individuals at high risk of Osteoporosis and osteoporotic fracture' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

As a consequence of the ageing of the society, osteoporosis (literally “porous bone”) and its  complications is becoming more and more prevalent, making the bone disease a health priority in many parts of the world. Currently osteoporosis is commonly known as a “silent killer” disease. Usually osteoporosis manifests itself in a drastic manner, i.e. through fracture of the osteoporotic bone in the affected individual. Until now little or no measures for prevention or early detection of this disease are taken, because no simple, yet sufficiently precise or sensitive tools for early detection of individuals at risk of osteoporosis are available. The overall objective of the currently proposed PoCOsteo project therefore is the development, clinical validation and preparation for commercialisation of a Point-of-Care tool for bone disease (a.o. osteoporisis) prevention, detection and treatment. To realize this objective a balanced consortium of 5 research partners and 3 SME’s has been brought together, and a well considered workplan devised. Two TRL3 technologies for individual proteomic and genomic electrochemical sensors, available from 2 consortium partners will form the base of the developments. The sensors will be further optimised, combined in a single microfluidic cartridge and integrated in a complete and  independent point-of-care bone health assessment tool. The tool will consequently be clinically validated in 2 hospitals (Graz and Tehran), and a business plan for a commercial start-up company wil be prepared for the intended valorisation of the technical and medical activities. The aim is to reach a TRL6 / TRL7 for the complete tool and for the combined microfluidci cartridges. The project will be supported and advised by the IOF, the International Osteoporosis Fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Language-Affect Interface in Parent-Infant Communication'.

assistant: **Concept**

Language, gesture, and affect are the three musketeers of parent-child interaction.  Although affect, our experience with emotions, plays a key role in communication, its developmental trajectory in the beginning of life remains unclear. How do infants develop affect recognition that corresponds to their native environment? How do they perceive affect from non-native cultures? How does language interact with affect perception, and how does infants’ (multi-) linguistic and cultural experience play a role? To further our understanding toward these questions, I propose to experimentally examine infants’ affectual development and its interaction with language in the first year after birth, and specifically, adopting a preferential looking paradigm where infants will watch videos of happy/angry expressions from various cultures along with languages that match or mismatch with the correspondent culture.This exciting project bridges psycholinguistic and sociolinguistic approaches. It discusses three main topics: infant culture-specific affectual development, language-affect interface, and the effect of multilingualism on affectual perception. In this project, I will also investigate the influence of social and linguistic factors on affectual perception, examining whether multilingual heightened sensitivity would extend to the affectual domain. Europe is changing more than ever towards a complex social environment, with interactions between languages and cultures. I hope to enhance European scientific excellence by contributing to a better understanding of infant culture-specific affectual development in various linguistic contexts. As a direct consequence, the outcome of the project may change parental attitude towards a diverse linguistic and cultural environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mechanism of Regulated Transcription Initiation'.

assistant: **Concept**

The regulation of gene transcription governs eukaryotic cell growth and differentiation. Despite its importance, transcription regulation is not understood at a mechanistic level. Regulation occurs mainly during initiation, when the enzyme RNA polymerase II (Pol II) assembles with ~50 polypeptides on promoter DNA. Regulatory signals are transmitted by the 25-subunit Mediator, and convert the initiation complex into a productive elongation complex. Ten years after the solution of the Pol II structure (Cramer et al., Science 2000, 2001), elongation is understood, but the structure and regulatory control of the initiation complex remain largely unknown. Here I propose to solve this central problem of molecular genetics and obtain a movie that shows how a gene is activated. Our recent structure of Pol II with initiation factor TFIIB (Kostrewa et al. Nature 2009) provides the starting point for the proposed risky and challenging structure-function analysis of regulated initiation. First, we will determine structures of Pol II in the initiating state. Second, we will solve the structure of the essential, gene-regulatory 7-subunit head module of the Mediator core. Third, we will establish ¿nascent transcriptome analysis¿ as a novel technique that measures mRNA synthesis rates globally, and will use it to probe the mechanisms of regulated initiation by structure-based mutagenesis in vivo. Expected results will open new horizons for investigating the function of eukaryotic genomes, and will have a strong impact on biomedicine, since deregulated transcription underlies many diseases, including cancers and certain metabolic dysfunctions. This ground-breaking research requires the long-term, flexible commitment of the ERC, to successfully compete with teams in the US and Japan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Iodine behaviour in the containment under severe accident conditions'.

assistant: **Objectives**

Iodine release to the environment is one of the most important radiological risks in case of a severe accident in a Light Water Reactor. To be able to predict the physical state and quantity of the released iodine as well as the time of release it is important to study the behaviour of iodine during simulated reactor accidents. The results of these studies will help adopt the appropriate accident management. Results from the first experiment of the Phebus-FP programme show that the iodine behaviour in the containment was not predicted correctly by pre-test calculations. The objective of the proposed work will be to develop l improved models (based on experimental data) for processes currently not well understood to help explain the results from Phebus-FP experiments. These models which will take into account silver/iodine reactions, the effect of rhenium and iodine related mass transfer will be compared with experimental results and implemented in existing computer codes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BELLA-S1 Building Europe Link with Latin America' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The BELLA-S1 proposal aims to provide for the long-term interconnectivity needs of the European and Latin American research and education networks, and answers the call for transatlantic connectivity to Latin America in the H2020 Work Programme 2014-15. The objective will be to strengthen connectivity to Latin America ensuring very high capacity, cost benefits and the shortest possible route, whilst stimulating diversity over the transatlantic segment. The objective will be met in two phases: phase one will procure an indefeasible right of use for a portion of the spectrum of a direct submarine telecommunications cable between Europe and Latin America; phase two will deploy one or more wavelengths, as required, on the spectrum procured to interconnect the GÉANT and RedCLARA networks, and provide for the intercontinental connectivity needs of the European and Latin American research and education communities.


**Keywords:** transatlantic, spectrum, Latin America, Europe, submarine cable, research and education, connectivity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unraveling the role of Nucleotide Excision Repair factors and the dynamic of chromatin structure in the repair of oxidative DNA damages in vivo' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Oxidation of DNA bases by reactive oxygen species (ROS) leads to mutations that have been linked with cancer and neurodegenerations. The occurrence of these major diseases increases upon organism aging. The life expectancy in western society and particularly EU has considerably increased in the XXth century. Thus mortality caused by cancer and neurodegenerations has become massive. Therefore fighting against aging of the population is our future medical challenge and understanding mechanisms reducing the impact of oxidative DNA damages can be one of the best weapons to win this non-violent war. Mouse mutants for Nucleotide Excision Repair (NER) revealed an unexpected link between DNA damages and premature aging. The UV lesions have been for historical reason the “model lesion” for NER. However the phenotype in patients and in the several mice model of NER deficiencies together with the Oxygen Radical theory of aging suggests that endogenously generated oxidative DNA damages could be at the roots of the premature and natural aging. The molecular mechanism of NER of UV-lesions has been extensively studied but the NER of oxidative DNA lesion has not been of major focus. Our goal is to molecularly dissect the involvement of NER proteins, in the repair of oxidative DNA damages in vivo. To understand a basic process of cell physiology like mechanisms of oxidative DNA repair we will use a multidisciplinary approach with techniques spreading from mass spectrometry to live cell imaging. Our first aim would be to evaluate the recruitment of NER factors to oxidative DNA lesions generated in living cells by using confocal microscopy and a laser irradiation generating specifically those lesions. We will investigate, by mass spectrometry, for the best candidate the partners recruited
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Test of advanced lubrication equipment' (LubSEP).

assistant: **Innovation**

Oil consumption by aero-engines is a major concern for both ecological and autonomy reasons. The air-oil separation technologies (de-oiler and de-aerator) have been long time enherited from past generation engine architectures. Based on current oil system requirements (oil consumption, mass, compactness, reliability) and technologies (brush and lift carbon seals), ULB-ATM and his partners will develop hardware for advanced oil separation equipment, build them and test them to validate the technology. These tests require also the development of specific instrumentation and measurement devices in order to carachterise properly the equipment.The partners will more specifically perfom the following activities:1. Design and test a centrifugal blower (order of magnitude of the working point: air flow rate of 200 m3/h with a delta pressure of 10 kPa with a rotational speed of 12.000 RPM.2. Design and test a demonstration unit of an air quality measurement device. The measurement device should measure the low oil quantity (order of magnitude: 0,1 l/h) in an air flow (order of magnitude: 200 m3/h).ULB-ATM will adapt its current test benches for lubrication equipment to the new requirements imposed by this application. All tests will be performed with the double objective of validating the design of the lubrication components as well as characterizing their performance with the qualification requirements in mind.ULB-ATM has already a full qualification of its test benches (obtained from Techspace Aero) for his ""clean oil"" lubrication test bench and his ""polluted oil"" lubrication test bench.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A New Approach to the Evolution of Texts Based on the Manuscripts of the Targums' (TEXTEVOLVE).

assistant: **Concept**

TEXTEVOLVE will study the Targums. Targums are Jewish Aramaic paraphrases of the Hebrew Bible. They are important because they provide a unique insight into what Jews believed God was saying to them through their sacred texts at transformative moments in Jewish history, particularly the aftermath of the First Jewish-Roman War (66–74 CE). The state of the art in the study of the Targums is defined by 1) methodology, and 2) the primary sources that are available. TEXTEVOLVE will go beyond the state of the art in both areas.Methodology — We do not possess the author’s original copy of any Targum. Rather, in most cases we have multiple copies preserved in much later manuscripts, all of which differ one from another. Existing methodology aims to reconstruct the earliest possible form of the text. But changes made by later copyists also yield important insights into evolving Jewish culture, theology, and praxis. Therefore TEXTEVOLVE reframes the dominant research question in the field so that neither the importance of the original wording nor the significance of subsequent changes is neglected. It asks: How did the text of the Targums evolve over time and why? TEXTEVOLVE will develop a new methodology, called Evolutionary Philology, that is capable of addressing this core question. It will use techniques from evolutionary biology that have not previously been applied to texts to achieve this. This will have implications across disciplines that work with historical texts.Primary Sources — To ensure the most robust possible dataset, TEXTEVOLVE will expand the pool of primary sources available for analysis. TEXTEVOLVE will find Targum manuscripts that have been ‘lost’ in un-catalogued or poorly catalogued collections, and will analyse for the first time recently discovered manus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigating Host-Microbial Interactions after Bariatric Surgery', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Obesity and related co-morbidities give rise to severe health and socioeconomic problems. Surgical treatment for obesity (bariatric surgery) is remarkably effective in the control of morbid obesity and rapid resolution of Type 2 Diabetes, and the number of such procedures is increasing rapidly in many obesity-prevalent countries. We, and others, have demonstrated that surgical interventions such as Roux-en-Y Gastric Bypass (RYGB) modulates gut hormone levels, induces systemic metabolic changes and results in the shift of the microbiome from Firmicutes to the Proteobacteria phylum. Although the gut microbiota have been implicated in the reduction of adiposity post-surgery, the long-term effect of altered gut microbiota on patients who have undergone RYGB, remains to be studied. Our recent data suggested that microbial activities are highly associated with inflammation and cancer. My research programme aims to investigate the RYGB-specific gut microbiota impacts on host physiology and colon cancer risk. To achieve this goal, I will employ a multidisciplinary approach that combines systems biology techniques with a bottom-up approach. This work will deliver phenotypic and mechanistic characterisation of the interplay between the host and the gut microbiota. The research findings will significantly contribute towards the understanding of fundamental molecular and cellular processes that are key in host and gut microbiota interactions. This will provide knowledge-based evidence of the gut microbial impact on human physiology, and has the potential to unravel novel prevention targets and promote a more thorough healthcare strategy for bariatric patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Interactions between dna-dependent protein kinase and components of the dna recombination/repair apparatus' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

DNA-dependent protein Kinase (DNA-PK) plays a central role in two processes involving DNA double strand breaks (DSB): (i) repair of DSB induced by ionising radiation, and (ii) V(D)J recombination that occurs in developing of B and T lymphocytes. DNA-PK has two components: DNA-PK catalytic subunit (DNA-PKcs) and Ku antigen. DNA-PKcs only becomes active when the Ku component binds to DSBs. Our poposal is to study the mechanism by which DNA-PK functions in these two processes. One attractive possibility is that DNA-PK, by protein-protein interactions, recruits the machinery necessary to carry out DSB repair or V(D)J recombination to the site of DNA damage. For this, I will try to identify in vivo interactions with human proteins using the two hybrid" system. Hopefully, once identified the gene(s) that interacts with DNA-PK, I will map its genome position(s), and obtain antibodys against the protein(s) to study its cellular localization. Further in vitro studies will be done, by inmunoprecipitation, using antibodies against DNA-PK and co-purifing DNA-PK peptides. "