RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DEVELOPMENT OF NEW AND IMPROVED DIAGNOSTIC TESTS FOR CONTAGIOUS BOVINE PLEUROPNEUMONIA IN EUROPE (CBPP)' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Background :Contagious Bovine Pleuropneumonia (CBPP) is a severe respiratory disease of cattle which causes high economic damage and has persisted in Europe for a long time. CBPP is caused by Mycoplasma mycoides subsp, mycoides sc variant and it is thought to be endemic in some areas of the Iberian peninsula and recent outbreaks have occurred in other European countries (France, Italy). The available serological diagnostic tests have a limited efficiency.The objective of this project is to develop and evaluate new and improved tests for the isolation, identification and differentiation of the causative agent, through: i) the development of a high quality antigen; ii) the development of new enzyme immunoassays based on monoclonal antibodies; iii) the evaluation of intradermal and gamma interferon tests for cell-mediated immunity; and, iv) the development of polymerase chain reactions tests. Short description of the project :The project will consist of the following tasks: - Improvement and standardization of the complement fixation test for CBPP; - Improvement of the media for transport and isolation of M. m mycoides SC; - Improvement of the biochemical identification of M. m mycoides SC; - Development of improved serological tests; - Development of tests for cell mediated immunity; - Development and improvement of polymerase chain reaction systems for the  detection of M. m mycoides SC; - Development of molecular diagnostic systems based on 16S ribosomal transfer RNA analysis; - Evaluation of tests in experimentally and naturally infected cattle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of super-wheat crops by introgressing agronomic traits from related wild species' (SWCD) under Seventh Framework.

assistant: **Objectives**

Wheat is one of the most important food crops in the world and understanding its genetics and genome organisation is of great value for genetics and plant breeding purposes. Despite is genome complexity (polyploidy), hexaploid and tetraploid wheats behave as diploids during meiosis. This means that each chromosome only recognises its identical (homologue) to pair and not the related chromosomes (homeologues). There are several pairing homologous (Ph) genes controlling chromosome pairing in wheat during meiosis. The strongest effect is associated with the Ph1 locus, which is located on the long arm on chromosome 5B. Ph1 appears to sense homology prior to the chromosomes coming into contact with each other at early meiosis. Thus, if the chromosomes are true homologues, they perfectly recognise each other, chromatin remodelling is synchronized and allows pairing and recombination to occur. If the chromosomes are homoeologous (related), remodelling is not synchronized and the chromosomes fail to pair and recombine. In the absence of Ph1, all chromosomes can remodel without the requirement for the presence of an identical or near identical chromosome, and this increases the chance of pairing between related chromosomes in addition to pairing between true homologues. In this project we want to analyse deeper this Ph1 behaviour and we also want to exploit ph1 mutants as a tool for wheat breeding programs to promote inter-specific recombination between related wild species. In fact, Hordeum chilense (wild barley with interesting agronomic traits for wheat breeding) introgressions will be developed into durum wheat to transfer desirable agronomic traits from this wild barley into wheat, like resistance to diseases or the increment in carotene content. Introgression lines will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ICT Enabled Public Services for Migration' (MIICT), addressing dissemination and exploitation.

assistant: **Impact**

MIICT, is conceived with the goal of designing, developing and deploying tools that address the challenge of migrant integration through the co-creation of improved ICT-enabled services with migrants, public sector services and NGOs (Non-Governmental-Organisations). Previous research has established that issues of integration, dissemination, employment (and unemployment), incapacity support and education rank highly among migrants of varying demographics; including different age groups, genders, education levels and immigration status [1]. Factors such as autonomy, perception, culture and history, as well as institutional constraints shape the dynamics and experiences of migrants [2], and highlight the complexity of the migration process. This complexity is also said to indicate diversity in migration and integration process as a result of the almost infinite combinations of factors that may impact upon migrants' experiences; influenced by the relationships between the economic, social, political and cultural factors that exist across a given juncture [3].
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A framework for the multi-objective optimization of timber gridshells under structural and energy-based criteria.' to be submitted under Horizon 2020.

assistant: **Abstract**

Why in the age of 4.0 industrial evolution and ubiquitous Artificial Intelligence, the construction industry has such a devastating impact on ecology? Architectural Design Optimization (ADO) can aid us in designing buildings and structures that can perform better than ever before. Despite the growing interest in the application of ADO to find zero-energy and cost-optimal solutions for buildings in academia, its influence on practice remains very limited. The main reason, preventing the wider adaptation of the optimization solvers in practice, is the lack of optimizers dedicated for multi-objective constrained optimization problems (CMOPs), while majority of the real-world design problems involve multiple criteria and diverse constraints. Moreover, there is no industry validated evidence on economic and ecological benefits of ADO.OPTIshell will introduce into Architectural Design Optimization an innovative optimization algorithm based on Swarm Intelligence (SI) dedicated for CMOPs. The results of this research will provide crucial information on applicability of SI methods for CMOPs in design area. The performance of SI will be assessed with different tuning parameters and compared to the existing Evolutionary Computation in solving ADO problems. OPTIshell will demonstrate the ADO benefits through the optimization and construction of solar timber gridshells powered by flexible perovskites modules - CarPort4.0 . Development and testing multi-objective optimization is one of the most relevant research directions in ADO. Introduction of the constrained multi-objective Swarm Intelligence optimization into architectural design will be a significant step towards evolution of ADO and wider adoption of optimization in architectural practice. The industry-validated benchmark may
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mating incompatibility among toxic and non-toxic strains of the dinoflagellate Alexandrium minutum' (MATEMIN), addressing dissemination and exploitation.

assistant: **Impact**

In modern society, incidents concerning Harmful Algal Blooms (HABs) are reported with an alarming frequency and there has been an apparent increase in HABs throughout the world over the last decades. Among the multiple poisoning syndromes linked to HABs, Paralytic Shellfish Poisoning (PSP) is the most widespread and significant on a global basis. Dinoflagellates within the genus Alexandrium are responsible for many of the PSP outbreaks in Europe. The geographic expansion of toxin-producing species, and in particular of species with the capability to form cysts, is believed to be aided by human activities such as the use of ballast water or the movement of shellfish stock from one area to another.The objective of the proposed study is to investigate a significant constraint to colonization of a new area by an introduced organism - namely reproductive barriers within a species, and in particular, between European toxic and non-toxic strains of the dinoflagellate Alexandrium minutum. The hypothesis is that mating between toxic and non-toxic populations results in cysts with a low viability. In addition, I aim to identify a genetic marker capable of distinguishing between toxic and non-toxic A. minutum. The ecological relevance of the proposed study is significant as mating barriers have the potential to affect biogeography of the investigated species as well as formation, persistence and the potential suppression of toxic blooms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cooperative International space station Research data Conservation and Exploitation' (CIRCE), addressing dissemination and exploitation.

assistant: **Impact**

The present coordination action intends to conclude the major gaps that need to be filled for the establishment and future development of an international e_infrastructure  able to effectively support and promote the exploitation of the scientific data produced by the International Space Station and other major space missions.The need for coordination stems from the large number of European partners and stakeholders involved in the space programmes and missing regulations and guidelines in terms of a general policy for data dissemination and exploitation in the past. It is expected that this coordination action will support a possible roadmap for the solution of the open issues that presently limit data exploitation in the space community.In this respect, it is expected that the outcome of this action will represent a valuable contribution for the definition of guidelines for future research programmes also in the framework of Horizon 2020. Particularly, this coordination action is expected to provide a more user-oriented perspective on the role of innovative technologies for a data e_infrastructure in the space research domain at a global scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797' (INNODIA), addressing dissemination and exploitation.

assistant: **Impact**

Preclinical type 1 diabetes (T1D) research has made important advances in recent years, but less progress has been made in translating findings from in vitro and animal models into effective clinical interventions. INNODIA aims to achieve a breakthrough in the way in which we study T1D to enable us to move closer towards prevention and cure of T1D. To this end, INNODIA joins together the leading European experts from the fields of basic and clinical T1D research, four leading pharmaceutical companies with strong expertise in the discovery and development of diabetes medicines and the two leading public organizations involved in T1D research into one comprehensive collaborative consortium. The clinicians in INNODIA oversee T1D registries and have access to large populations of children and adults with T1D and family members at increased risk of developing the disease. The basic science researchers are experts in beta-cell pathophysiology, immunology, biomarker discovery, bioinformatics, systems biology and clinical trial design. INNODIA will accelerate understanding of T1D through coordinated studies of unique clinical samples and translation-oriented preclinical models. This should deliver novel biomarkers and interventions for testing in appropriately designed trials, to be developed in active collaboration with regulators and patients. INNODIA provides access to unique historical biorepositories and will create the Clinical Sample Network, a clinical EU infrastructure to recruit T1D subjects at diagnosis and at-risk relatives. These individuals will be deep-phenotyped and will provide biosamples, allowing the establishment of a ‘living biobank’ of subjects consented for recall. They will be characterized using standardized clinical, genetic and metabolic phenotyping p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Modeling Disease through Cell Reprogramming: a Translational Approach to the Pathogenesis of Syndromes Caused by Symmetrical Gene Dosage Imbalances'.

assistant: **Concept**

The fundamental limitation in our ability to dissect human diseases is the scarce availability of human tissues at relevant disease stages, which is particularly salient for neural disorders. Somatic cell reprogramming is overcoming this limitation through the derivation of patient-specific induced pluripotent stem cells (iPSC) that can be differentiated into disease-relevant cell-types. Despite these tantalizing possibilities, there are critical issues to be addressed in order to secure iPSC-modeling as a robust platform for the interrogation of disease aetiology and the development of new therapies. These concern the taming of human genetic variation, the identification of differentiation stages in which to uncover and validate phenotypes, and finally their translational into drug discovery assays. This project confronts these challenges focusing on the paradigmatic case of two rare but uniquely informative disorders caused by symmetric gene dosage imbalances at 7q11.23: Williams Beuren Syndrome and the subset of autism spectrum disorders associated to 7q11.23 microduplication. The hallmark of WBS is a unique behavioral-cognitive profile characterized by hypersociability and intellectual disability in the face of comparatively well-preserved language abilities. Hence, the striking symmetry in genotype and phenotype between WBS and 7dupASD points to the 7q11.23 cluster as a surprisingly small subset of dosage-sensitive genes affecting social behaviour and cognition. We build on a large panel of iPSC lines that we already reprogrammed from a unique cohort of WBS and 7dupASD patients and whose characterization points to specific derangements at the level of transcriptional/epigenetic control, protein synthesis and synaptic dysfunction. Through the integration of transcri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Soakback Assessment using LAttice Boltzmann Method and Aerothermal Nodal-network for the Design of the Engine-bay Region' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

As part of H2020 program, CleanSky II aims at pushing forward the whole EU aeronautical sector to a worldwide prominent place as well as addressing ambitious targets in reduction of pollution and fuel consumption.Within the “Sustainable and Green Engine” Integrated Technology Demonstrator, WP 3 Business Aviation / Short Range Regional TurboProp Demonstrator aims to bring to market a new generation of TurboProp. The present call JTI-CS2-2017-CFP06-ENG-01-21, associated with WP3.5.3 Engine nacelle Demonstrator and WP3.6.1 Thermal Management, ultimately aims at assessing the temperature inside the Engine Bay of an ARDIDEN3 TurboProp during soak-back.The projects deploys in 3 phases. First, perform high-accuracy, state-of-the-art LBM simulations, of the full engine. Second, develop a reduced-cost, Nodal-network model, for the channel region. Finally, combine LBM (accuracy) & Nodal methods (reduced-cost) to assess soak-back at acceptable cost in the TP Demonstrator.Challenges are numerous: Physical (Free Convection/ High Mach numbers); Modeling (LBM/ Nodal Network Coupling); Computational (Long-Transient/ Engine Geometry/ 3D Fluid & Solid). The highest levels of numerical expertise are required.The present proposal, SALAMANDER “Soakback Assessment using LAttice Boltzmann Method and Aerothermal Nodal-network for the Design of the Engine-bay Region”, offers cooperation between EXA, world-leader in LBM solutions, and ALTRAN, world-leader in Engineering Solutions, Fluid and Thermal Engineering Expertise Center. The Call combines EXA powerful LBM software, with an expertise on Soak Back, to ALTRAN expertise in Aerothermal and Nodal modeling. This strong partnership ensures this Call success.Eventually, the outcome model delivery will allow the Topic Leader to improve the design o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Interaction between a2a and nmda receptors in parkinson 's disease'.

assistant: **Innovation**

The Rudolf-Boehm-Institute of Pharmacology and Toxicology at the University of Leipzig seeks three post-doctoral fellows for a project regarding the co-expression of adenosine A2A and N-methyl-D-aspartate receptor (NMDA) subunits in Parkinson's disease. Whereas the antagonistic interaction between adenosine A2A and dopamine D2 receptors situated at the striatopallidal subpopulation of medium spiny neurons is generally supposed to be involved in the ethiology of Parkinson's disease there is much less knowledge on a recently described antagonistic interaction between NMDA and A2A receptors. Degeneration of dopaminergic neurons and alteration of NMDA receptors appears to be a major pathogenetic feature in Parkinson's disease. Accompanying changes in the function or expression of A2A receptors is a highly important prospective field of research. The investigations will be performed on brain tissue of Parkinson patients and controls, and in a Parkinson model in rats (6-hydroxydopamine (6-OHDA)- lesion of the substantial nigra). The expression of the NMDAR subunits (splice variants) and A2A as well as D2 receptors will be investigated immunohistochemically, by in site hybridization, and by other molecular biological methods dealing with topical aspects. The investigations will take place in the Rudolf-Boehm-Institute of Pharmacology in cooperation with the Department of Neuropathology. All logistic and modern technical facilities are available for a successful completion of the study. Applicants should be qualified in histochemistry and molecular biology and should be interested in neuroscience topics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantum coherence in photosynthesis: towards single-molecule light-conversion devices' in the context of a Horizon 2020 call.

assistant: **Objectives**

Photosynthesis performed by plants, algae and photosynthetic bacteria is the biological process that transforms solar energy into chemical energy with high quantum efficiency. A complete understanding of the factors that modulate the efficiency of this process is a challenge centered at the nexus of fundamental physics and biology, and obtaining that knowledge could pave the way for the design of the next generation of cheap and highly-efficient light-conversion devices. The main aim of this project is to understand how quantum coherence modulates the efficiency of photosynthesis. Quantum coherence is likely to be involved in not only the first ultrafast stages of excitation energy transfer in the photosynthetic light harvesting antenna but also in the charge separation process in the photosynthetic reaction center by coupling to specific vibrational states of this pigment-protein complex (Romero et al, Nature Physics 10, 676-682, 2014) .  Here we propose to use time-resolved coherent anti-Stokes Raman spectroscopy and two-dimensional photon echo spectroscopy to demonstrate the specific vibrational modes that sustain quantum coherence at the single molecule level. Time-resolved anti-Stokes Raman spectroscopy will provide an insight into the specific vibrations in the molecule that lead to sustained quantum coherence in the charge separation steps of photosynthesis. Results will be confirmed using two-dimensional photon echo spectroscopy and rationalized in a Redfield theory framework. To assess the role of energetic disorder, reaction centers will also be characterized using a combination of single-molecule techniques in order to correlate the quantum coherence arising at the single-molecule level with the efficiency of the whole ensemble. To achieve this, a new techniq