RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New insights into wheat meiosis:  Crossover resolution in the absence of the Ph1 locus' under Horizon 2020.

assistant: **Concept**

This project ultimately aims to increase the crossover frequency in bread wheat (T. aestivum), which would result in a higher number of recombination events and would be a powerful tool for plant breeding. Thus the results of the proposed research are relevant to crop improvement as well as to human health. In the next 50 years, we will require as much wheat as has been produced since the beginning of agriculture. There are 1.5 billion dependent poor in the world, of which 300 million living in countries surrounding Europe are at risk of starvation in the future. Finding solutions to address the problems of wheat production will be a dominant topic in European plant science. Specifically, this project builds on the work of the host group on the Ph1 locus - the major wheat locus controlling the specificity of chromosome pairing and recombination, and which ensures high fertility. Future breeding strategies for wheat will require exploitation of diversity in wild relatives, and manipulation of the Ph1 locus will be a powerful tool to facilitate introgression of traits from these related species. Recent work in the host group has shown that Ph1 locus carries cdk2-like kinases, and that deletion of Ph1 increases protein phosphorylation levels, altering the homologue pairing specificity. A major objective of this project is to characterise the alterations in the phospho-proteome of the meiocytes that result from deletion of the Ph1 locus. Recent results from a group studying meiosis in C. elegans have also shown that meiotic pairing specificity and recombination depend on protein phosphorylation levels, suggesting that the mechanism underlying Ph1 may be quite general. During this project we will collaborate with the C. elegans researchers to explore the similarities between
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Expressed sequences (EST) as tags for functional genes for genetic characterisation of flowering woody ornamental shrubs from an oriental origin', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Genetic resources of ornamental plants are in general poorly covered by international co-operation initiatives for characterisation and protection of (wild) germplasm. However, a well-considered application of these genetic resources, e.g. in breeding, is the best guarantee for a sustained conservation. This proposal focuses on flowering woody ornamental shrubs from an oriental origin: Rhododendron, Camellia, Hydrangea and Paeonia. These species have a long-lasting tradition of cultivation in their countries of origin and are there national symbols of living heritage. They are integrated in the EU horticultural sector since their introduction 2 centuries ago and are highly appreciated by the EU consumers too. Both in Europe as in the East, research is initiated for these species; however, joint actions are rare because of different reasons (distance, problem of communication, no network).The main objective of this proposal is to re-establish the link between Europe and the East for research about these species. Partners involved cover important ornamental production areas in Europe (Belgium, region of Gent; Italy, region around the North-Italian lakes; France, region of Angers) and focuses on China and Japan as being important for native plant genetic resources and also well established centres of competence for research in flowering woody ornamentals. The exchange program will support to provide common tools for the characterisation and application of interesting plant genetic resources for plant breeding purposes. The study of expressed sequences (EST) as tags for functional genes hooks up this ambition to the current state-of-the-art research in plant sciences.The working program combines 4 WP  oriented towards each of the 4 species under study, and WP5 that supports
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'European prospective study of environment, allergy and the lung (preferred name - European community respiratory health survey II)'.

assistant: **Innovation**

1. Objectives and expected achievements The proposed study is the nine year follow-up phase of a multicentre, prospective study of more than 10,000 young adults living in Europe. The proposed study has five overall objectives1. To determine the incidence and prognosis of allergy, allergic disease and low lung function in adults living in Europe.2. To describe the distribution of exposure to known or suspected environmental risk factors associated with the incidence and prognosis of allergy, allergic disease and low lung function.3. To determine the risk attributable to chronic exposure to these environmental risk factors for the incidence and prognosis of allergy, allergic disease and low lung function.4. To identify subgroups within the population based on gender, prior disease status, bronchial responsiveness and genetic risk who may be more susceptible to these environmental risk factors and measure their excess risk.5. To establish a DNA bank taken from representative samples of the population that can be linked to health and environmental information.Objective 1The incidence (or remission) of the following specific health outcomes will be determined using standardised methods of assessment of :* allergy - sensitisation to environmental allergen as measured by the presence of serum specific IgE to house dust mite, cat, grass, Cladosporium* allergic disease - respiratory symptoms suggestive of asthma, physician diagnosed asthma, hayfever and nasal allergies as reported within a questionnaire.Change in the following continuous measures will be described* allergy - serum total IgE * lung function - the clinical measures of respiratory function, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) * bronchial responsiveness to methacholine (BHR)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Wavelength tunable Advanced Single Photon Sources Non-laboratory Environment Specification and Testing' (WASPSNEST), addressing dissemination and exploitation.

assistant: **Impact**

Triggered single photon sources are key enabling tools in the new technology of quantum communications and a host of quantum optics research, but have not found widespread use because robust and portable devices have yet to be commercialised. The FP7 WASPS project is completing laboratory-based demonstrator experiments for a new range of plug-in single photon sources that can ultimately be operated at ambient temperatures and in non-laboratory environments. The devices, based on nitrogen-vacancy colour centres in diamond coupled to optical microcavities, offer a degree of wavelength tunability and a flexible design in which the active component can be replaced and upgraded. Work towards construction of a field-testable prototype device has started. In this Innovation Launchpad project, we propose to carry out critical steps in the development and field testing of this prototype that will provide key performance information to companies looking to manufacture and market the technology. These will involve innovative refinement of the active module containing the cavity and single photon emitter, development of module assembly protocols compatible with manufacturing, and testing of the prototype in a free-space quantum key distribution system. The project will bring robust triggered single photon sources closer to market and will promote innovation and entrepreneurship within the H2020 FET programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Explosive phenomena in the Universe: Gamma-Ray Bursts and SuperNovaRemnants as high-energy particle acceleration sites' (SHALOM).

assistant: **Concept**

The acceleration of high-energy particles at collisionless shocks in astrophysical plasmas is a common phenomenon in the Universe and takes place in a variety of systems, from the heliosphere up to the most distant cosmic sources. The best known example for such non-thermal particle populations are cosmic rays, but additional evidence for the existence of high energy particles comes from observations of non-thermal synchrotron and inverse Compton emission from several sources, as pulsar wind nebulae, jets from active galactic nuclei, gamma-ray bursts, and supernova remnants. In all these sources collisionless shocks are thought to be responsible for the conversion of a significant fraction of the flow energy into relativistic particles with power-law non-thermal spectra. The most popular candidate for particle energization at astrophysical shocks is the so-called diffusive shock acceleration mechanism (first-order Fermi mechanism), where charged particles gain energy by scattering back and forth between the converging upstream and downstream plasmas. In collisionless astrophysical plasmas the source of scattering is provided by magnetic turbulence rather than by Coulomb collisions. Efficient acceleration requires that particles repeatedly cross the shock. For the accelerated particles a power-law spectrum is the natural product of collisionless shock acceleration.I propose to investigate the implications of shock acceleration in gamma-ray bursts and in supernova remnants and to set constraints on the acceleration mechanism. This research project consists of two parts, one concerning the acceleration of electrons at the external shocks of gamma-ray bursts and the resulting emission, and the other one focused on the acceleration of cosmic rays at the front shock of supern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding parents' perspective on childhood disability. Strengthening expertise through qualitative validation of an explanatory model', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

ObjectiveThe researcher's specific expertise in the sociological approach of disability issues will be placed within the larger framework of Disability Studies. More specific, his key competencies in childhood disability research will be further developed through qualitative validation in Iceland of his recently developed explanatory model for care-related decision-making in parents of congenitally deaf children. This will be guided by the following specific research objectives: (1)to investigate the relevance and importance of the different clusters and factors in the explanatory model, including addition of new relevant factors; (2)to assess the relations in the model between different clusters and factors, and to make additions/modifications where necessary; (3)to assess the implementation of the model for analysing parents’ experiences throughout the care trajectories within a specific national context – in casu Iceland.ImplementationThis research training project is based on qualitative data to be collected among Icelandic parents with a deaf child born 1998-2010, through 2 rounds of semi-structured interviews. Theoretical and methodological training will be centred around qualitative data analysis aimed at providing insight into how parents arrive at care-related decisions, which factors play a role in decision making and how these are interrelated. Also, using the model, the specific organisation of national early intervention services will be analysed.Scientific and career valueDevelopment of frameworks for sociological analysis of parents' perspectives in issues of childhood disability an important challenge in European disability research. This mobility proposal also enables the researcher to build on his an innovative explanatory model. The activities in this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification of the effectors and targets of the pre-tcr by genetic complementation of cd3-e deficient thymocytes' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content Recent studies in the mouse have shown that double negative-inmature thymocytes can assemble a new TCR isoform that is devoid of TCRa chain and is referred to us the pre-TCR complex. The assembly and inducing functions of this complex are likely to be coupled to the achievement of productive TCRBeta chain gene rearrangement. In this way, the CD3 subunits associated with the pre-TCR trigger a cascade of signals wich drive the inmature double negative cells to the more differentiated double positive stage: e.g., thymocytes from mice deficient in one chain of the CD3 complex (# -chain) are unable to assemble a pre-TCR and blocked at the double negative stage. In our project the main objective is the identification of gene products acting downstream of the pre-TCR/CD3 complex. To this end, we will try to develope a genetic screen that combines the production high-titer helper-free retroviruses by transient transfection and the subsequent infection of early thymocytes in reaggregate organ culture. Such kind of approach, combined with the use of thymuses originated from various mutant mice whose T cell development is arrested at different stages, should permit us to analyse any candidate genes implicated in T cell development in a brief period (2-3 weeks for each). In this context, the CD3-E deficient mice developed at the host institution constitute a particularly appropriate gene transfer recipient to study the regulation of TCR gene rearrangement since their V(D)J recombination machinery is intact. However, my long term objective is to identifie new genes implicated in the development of thymocytes. To this end, I plan to construct a cDNA library and introduce it into CD3-E-deficient thymocytes; the resulting double positive cells will be is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Use of microbial transglutaminase to reduce egg protein allergenicity' (EGGALL) targeting Seventh Framework.

assistant: **Abstract**

The aim of this proposal is to investigate whether transglutaminase mediated modification can be used to reduce the allergenic potential of ovomucoid and ovalbumin present in egg white. The rising levels of allergies are a serious cause for concern within the European Union, especially in children. Allergic diseases affect between 10-20% of the population and usually start during infancy, childhood or adolescence, and up to 5% children have food allergy (www.foodallergy.org). Food allergies are more prevalent in children, due to an immature gastrointestinal epithelial membrane barrier, allowing more proteins through the barrier and into circulation. Allergy to egg is one of the major allergies in infants and young children. This project will involve studies that could provide important information about how to manage egg proteins hypersensitivity. Modification of proteins by transglutaminase is thought to have beneficial effects on their allergenic properties. Through improved understanding of this effect, we aim to develop strategies for enzymatically modifying the major egg allergens such as ovalbumin and ovomucoid with transglutaminase to reduce the immunoreactivity of these proteins. To achieve this we require a multidisciplinary approach, bringing together the following key skills and expertise: · Biochemistry skills and expertise are required to modify ovalbumin and ovomucoid using transglutaminase and to evaluate the antigenicity (ability of a protein or a peptide to bind an antibody) and the allergenicity of the modified forms. · Physiological expertise is required to define and develop accurate models of protein digestion which are representative of the in vivo situation. In particular models that are relevant to the infant gut where egg allergy is developed. ·
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Regions for climate change resilience through Innovation, Science and Technology', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

RESIST will strengthen the resilience and accelerate the transformation and increase adaptive capacity of 12 climate-vulnerable EU regions, implementing 4 large-scale demonstrators of resilient innovations for Climate Change Adaptation (CCA) with quintuple-helix partnerships (including 1 in a less developed region) and promote transfer of know-how and innovative solutions to 8 twin regions (of which 4 less developed regions) through both physical mutual-learning activities and innovative immersive digital twins. The consortium will engage EU associations, CCA research groups, scientific experts, social engagement and communication institutions, innovation agencies and 1 Venture Capital Fund to co-create and validate innovative solutions, raise awareness, leverage citizens participation and promote sustainable exploitation of results towards the markets. RESIST will contribute to the EU agenda on CCA, through intervention in 3 main areas:Promote and demonstrate an innovative, more participative approach to resilience and CC adaptation in 4 demonstrator and 8 twinning regions (including 5 less developed regions in total) demonstrating >12 new solution lines, accelerating regional resilience and helping reach the adaptation-mission objectives of ‘building resilience and upscaling solutions through 100 demonstrators and accelerating the transition in 200 pilot regions and communities by 2030’ reaching already 4% and 6% of these aims by 2027, with 4 demonstrators and involvement of 12 regionsCo-design and contribute to the development of new regional measures, policy instruments and social and technological solutions in 12 regions involving 22m citizens, increasing awareness/resilience by 10% and levels of green investments by 20%, reducing economic losses due to natural haz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Study of the Listeria monocytogenes gene expression profile in ready-to-eat foods of animal origin by the application of the omics and the bioinformatics/biostatistics disciplines' in the context of a Seventh Framework call.

assistant: **Objectives**

Although the rate of food contamination with Listeria monocytogenes is low, the mortality rate that is caused by this microorganism is high,and for this reason, it is placed on the top of the list of pathogens of concern for the public health and consequently for the food industry. L.monocytogenes has emerged as a food-borne pathogen the last decades, due to changes in food processing, consumer habits and thedemand for minimally processed foods. The molecular mechanism of virulence has gained a lot of attention and many steps of thiscomplex process have been elucidated to various levels. All L. monocytogenes strains found in foods should be considered to bepathogenic. However, the relative virulence of individual L. monocytogenes isolates can vary substantially. The genetic basis underlyingthese virulence differences is not yet understood. Differences in gene content exist between strains of different serovars and origins.Differences among strains could also be due to different gene expression/regulation of the core genes of the microorganism. The ability torapidly determine the pathogenic potential of L. monocytogenes strains is integral to the control and prevention campaign againstlisteriosis. Throughout the years, different approaches have been employed to assess virulence: in vivo bioassays, in vitro cell assays andtargeting virulence-associated proteins and genes. However, these methods have disadvantages such as the need for laboratory animals(bioassays) and the time constraints. Furthermore, targeting virulence genes gives only an indication of the virulence potential of strains.Nowadays, powerful alternatives such as microarrays and reverse transcriptional quantitative polymerase chain reaction (RT-qPCR) areavailable that can assist in the definition of the vir