RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The  contribution of the  exosporium of Bacillus  anthracis  to survival'.

assistant: **Innovation**

The  exosporium  is not unique to Bacillus anthracis and is present in all members of the B.cereus group and  some clostridia.   The  function  this  complex structure plays in the survival of these spores is as yet unknown. One possibility is that it  acts as a physical barrier  passively  reacting with biocides before they have the chance to reach essential molecules located within the spore core. We propose to  determine the contribution the exosporium makes to environmental survival and biocide resistance. In addition the exosporium contributes to intracellular survival by masking inflammatory signals located in the spore coat thus  preventing  the infected macrophage from mounting a pro-inflammatory immune response.   In addition  to playing a passive role in survival we recently reported the presence of biologically active enzymes such as alanine racemase within the exosporium which prevent germination under sub-optimal conditions encountered in soil and infection.  This  is an extremely novel  concept as  the spore has long been thought of as an inert particle who’s intrinsic  resistance to environmental  insult enables it to lie dormant until conditions are conducive to growth.   In addition to regulating germination  the exosporium  contains enzymes such as superoxide dismutase and an arginase which contribute to the intracellular survival of the organism by inhibiting the activity of antibacterial radicals.  By understanding the contribution the exosporium makes to intracellular survival  we  will be able to design therapeutics which enhance the ability of the macrophage to kill the organism.  This proposal represents the continuation of a program of research initiated by the applicant while working in the U.S.  Its funding  will  enable the researcher to esta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Disruptive sustainable TECHnologies FOR next generation pvWINdows'.

assistant: **Objectives**

Tech4win proposes a very innovative transparent photovoltaic (PV) window concept that is based on the adoption of a tandem inspired structure combining an inorganic UV selective multifunctional coating (including UV filtering and UV selective PV functionalities), with an organic IR selective PV device. This will allow fully exploiting the IR efficiency and transparency potential of organic based solutions together with the robustness and stability of inorganic thin film concepts, combining sustainable and industrial compatible technologies with demonstrated potential for cost reduction, and avoiding the use of critical raw materials to ensure sustainable mass deployment. This “tandem inspired structure” will be able to generate on-site renewable energy (PCE ≥ 10%, with a long term goal ≥ 12%) guaranteeing a high-transparency degree (AVT ≥ 60% with a long term goal ≥ 70%, and CRI ≥ 70) and all by a competitive manufacturing costs. This novelty lies precisely in the capacity to protect the most active PV layer (IR selective organic solar cell) through the filtering of UV radiation, extending the lifetime of the PV hybrid device to ≥ 10 years (with a long term goal ≥ 25 years). To fulfil these objectives, a very well balanced multi-sectorial consortium comprising reference Research Centers in the different PV technologies involved in the window concept, together with high-tech European Companies from different sectors including relevant stakeholders involved in the value chain (Organic materials, Industrial Equipment developers, PV module producers and BIPV system manufacturers). This scenario constitutes an excellent business opportunity to satisfy the growing BIPV market to commercialize a unique cost-effective solar window solution, fully feasible as an active product c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A fully integrated, animal-free, end-to-end modelling approach to oral drug product development' to be submitted under Horizon 2020.

assistant: **Abstract**

Oral drug products are preferred by hundreds of millions of patients in Europe. Yet, the challenges around formulating drugs for oral administration have increased tremendously over the last 30 years, mainly because most drugs coming through the Pharma pipeline are too poorly soluble to be efficiently absorbed from the GI tract. A quantum leap in identifying the optimal formulation for a new drug in the most efficient way possible is urgently needed to keep the Pharma industry in Europe competitive. Further, due to the enormous challenges in formulating poorly soluble drugs for oral administration, the numbers of animals used to screen formulation prototypes are increasing, despite EU commitment to reducing animals in research. The InPharma Consortium provides a unique solution to solving these important challenges.The InPharma EID will strengthen Europe’s innovation capacity and leadership in the Pharma sector, specifically in drug formulation. Exceptional intersectoral training will be provided to 13 ESRs through pioneering research focused on harnessing computational pharmaceutics, Biorelevant in vitro testing and PBPK modeling, generating an integrated, end-to-end, animal-free approach to formulating poorly soluble drugs for oral administration. ESRs will undergo specialized training program to build proficiency in essential research and industry disciplines, while training in professional skills and entrepreneurship will prepare them to become trailblazers in pharmaceutical formulation.A highlight of InPharma is the proven, successful collaboration among Consortium experts in the design, evaluation and implementation of enabling formulations for oral delivery. This EID will immerse ESRs in highly dynamic industrial environments under the supervision of leading acad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Phylogeny and ethnobotany: Testing predictive approaches to plant drug discovery in the genus Aloe L. (Asphodelaceae)'.

assistant: **Innovation**

Dr Olwen Grace has worked at the Royal Botanic Gardens, Kew in the United Kingdom since 2004. She was recognised as a promising young scientist in South Africa where she began her research career in botany, and completed a part-time PhD in Plant Science at the University of Pretoria in 2009. This proposal, ALOE-DIVERSITY, is for a 24-month intra-European career development fellowship at the Pharmacognosy Laboratory in the Department of Medicinal Chemistry, University of Copenhagen in Denmark (host institution). Dr Grace will draw on a range of state-of-the-art molecular, biological, chemical and analytical techniques to produce the first robust phylogeny of Aloe (Asphodelaceae) including 200 taxa representing over a third of the diversity in this speciose genus, and novel chemical and bioactivity data for at least 50 Aloe species representing the phylogenetic diversity of the genus. The interdisciplinary nature of ALOE-DIVERSITY will significantly extend the evaluation of the ethno-guided and phylogenetic approaches to medicinal plant research. Aloe is a particularly appropriate candidate for this study due to the exceptional diversity, ethnobotanical and economic value of species such as Aloe vera L., as well as their medicinal properties and the growing concerns for their conservation. Through ALOE-DIVERSITY, Dr Grace will add new insights into predictive approaches to plant drug discovery and the identification of measures necessary to ensure the sustainable use of Aloe in future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Combinatorial chemistry as a tool for the development of sustainable polyurethane materials' (COMBIPUR) under Sixth Framework.

assistant: **Objectives**

Polyurethanes are polymers that are produced in a big range of different forms. They can be either very light or heavy, depending on the density, and can be made as elastomers or foams in different hardness ranges. Today, polyurethanes are produced by using raw materials that are known for years to people skilled in the art. However, the drive for cleaner and environmentally friendly products and the increasing awareness of customers is pushing the industry towards systems that are not based on suspected chemicals.The list of potential alternatives and their combinations is almost infinite. In order to find the most suitable alternatives, the use of combinatorial chemistry and high throughput screening methods could offer a lot of benefits. In this process the synthesis and characterization of the materials is done in parallel on miniature samples arranged in an array format, resulting in cost and time savings. Because of the recent advancements in analytical instrumentation, robotics and computer software, this method is getting more and more accepted in research. The present project will allow for the first time to apply this methodology to polyurethane materials, what may lead to new structure / property relationships.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting Subchondral Bone Marrow Lesions, Microdamage and Remodelling using Novel Bisphosphonate-Loaded Delivery Systems to Prevent Post-Traumatic Osteoarthritis after Acute Knee Injury' (NovelKnees), addressing dissemination and exploitation.

assistant: **Impact**

Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP. Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee. After injury, direct cartilage damage is rarely present, but in 80% of cases Bone Marrow Lesions (BMLs) are detected by MRI. These may be linked with microdamage in subchondral bone (region under the joint) – but this is uncertain. My aim is to develop a new therapy, delivered by injectable microparticles, to target subchondral bone microdamage and prevent PTOA. The project has three objectives: (1) Determine relationship between BMLs & microdamage (2) Determine role of bone remodeling during repair (3) Develop injectable alginate-microparticles loaded with bisphosphonate (bone targeting agents), to prevent PTOA. I will work at the Royal College of Surgeons in Ireland (RCSI), with my supervisor Prof. Fergal O’Brien, who is a world leader in biomaterials and drug-delivery. He leads the Tissue Engineering Research Group (TERG), and is senior PI at the Trinity Center for Bioengineering (TCBE) and the Advanced Materials and Bioengineering Research (AMBER) group. As European leaders in our field, my collaboration with them will expand my competencies/transferable skills and allow advanced multi-disciplinary training from experts. My expertise will also feedback and provide knowledge in mechanobiology and a new network of international collaborators. I will also develop skills in leadership, reporting, financials, dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SMEntorEGE' (SMEntorEGE) under Horizon 2020.

assistant: **Objectives**

The objective of SMEntorEGE is to support the regional SMEs to enhance their innovation management skills by improving efficiency and effectiveness of innovation processes, thus contributing to smart growth. Two groups of SMEs are targeted for the services that will be given under the project. The first group involves the SMEs who are the beneficiaries of “Horizon2020's SME instrument” or other EU Funded Schemes such as FP7, EUREKA, EUROSTAR, but who need technical support in innovation management to enhance successful exploitation of the project and its contribution to the companies’ growth. The second group consists of SMEs with potential for international growth via product/process/service/business model innovation but who lack the knowledge, skills to manage innovation activities. Two different services will be provided throughout the project period. “Key account management” for the beneficiaries of the SME instrument will focus on identifying bottlenecks to the creation of economic impact in companies benefitting from EU grants and address these bottlenecks with the help of capable Coaches and with the aid of KAM services of EEN. “Enhancing SME innovation management capacity” for innovating SME independently from a specific project will focus on increasing the efficiency and effectiveness of innovation processes in SMEs with significant innovation activities that could potentially become beneficiaries of European research and innovation supports, but not have effective access to consulting services for innovation management. As a result of the project, new types of standardised innovation support methodologies will be developed, the skills of the staff from the existing consortia will be improved, comprehensive innovation support will be given, two novel assessment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'RESilience to Early Developmental Adversity: can children's environment help them overcome the odds?' in the context of a Horizon 2020 call.

assistant: **Objectives**

Socioeconomic inequalities in childrens neurodevelopment and mental health are observed from early onwards and widen over time. Moreover, children whose parents are immigrant, particularly if they belong to ethnic minority groups, may be especially vulnerable. Yet there are important inter-individual differences in development, implying the possibility of resilience. My project will examine the consequences of multiple forms of socioeconomic adversity in childrens family and broader social environment with regard to their neurodevelopment and mental health, testing the role of social supports as sources of resilience. Specifically, I will rely upon longitudinal data collected from the ELFE child cohort study, a nationally representative sample of 18 321 children born in France in 2011 and followed-up to age 10.5 years, which will be linked with longitudinal administrative and geographical information characterizing neighbourhoods of childrens school and residence, as well as healthcare use data. Potential resilience factors will include familial (e.g. relations between the child and his/her mother and father, grandparents involvement) and contextual social supports (e.g. childcare prior to school entry, neighborhood social capital). Lifecourse patterns of adversity and resilience at each level of analysis will be identified using statistical methods developed for high-dimensional data and their influence on childrens development will be ascertained applying methods that strengthen causal inference (e.g. propensity scores). The results will help clarify 1) the ways in which lifecourse patterns of exposure to adversity in the family and childrens broader social environment can influence neurodevelopment and mental health, particularly among children of immigrants; 2) fami
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Charting the space of Conformal Field Theories: a combined nuMerical and Analytical aPproach' in the context of a Horizon 2020 call.

assistant: **Objectives**

Conformal Field Theory (CFT) was originally conceived in four and three dimensions, with applications to particle physics and critical phenomena in mind. However, it is in two dimensions that the most spectacular results  have been obtained. In higher dimensions, there used to be a general feeling that the constraining power of conformal symmetry by itself is insufficient to tell nontrivial things about the dynamics. Hence the interest in various additional assumptions. This is not fully satisfactory, since there are likely many CFTs that do not fulfill any of them.The main focus of this proposal is to take a fresh look at the idea that the mathematical structure of CFTs is instead such a strong constraint that it can allow for a complete solution of the theory. This program, known as conformal bootstrap, has provided a new element in the quantum field theory toolbox to describe genuine non-perturbative cases.This project aims to explore new directions and push forward the frontiers of conformal filed theories, with the ultimate objective of a detailed classification and understanding of scale invariant systems and their properties. CFT-MAP will develop more efficient numerical techniques and complementary analytical tools making use of two main methods: by studying correlation functions of operators present in any quantum field theory, such as global symmetry conserved currents and the energy momentum tensor; by inspecting the analytical structure of correlation functions.The project will scan the landscape of CFTs, identifying where and how they exist. By significantly improving over the methods at disposal, this proposal will be able to study theories currently are out of reach.Besides the innovative methodologies, a fundamental outcome of CFT-MAP will be a word reco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'PREcession-based drive mechanisms for high-PREcision energy-efficient POSitionining devices' (PRE2POS).

assistant: **Innovation**

PhiDrive and Arquimea´s Pre2Pos project is a Phase 1 winning project from the Horizon 2020 SME Instrument Space call of September 2014. The project is based on the industrialisation and commercialisation of rotary actuators, using an innovative motor which takes advantage of the micrometric deformation displacement of piezoelectric stacks, shape memory alloys and other smart materials to achieve infinite rotary or linear motion. Our plan is to include these rotary actuators in key equipment and mechanisms used in Space and in particular on satellites, such as Solar Array Drive Mechanisms (SADMs), Antenna Pointing Mechanisms (APMs) or Deployment Mechanisms (DMs), where high precision, low weight, energy efficiency and low manufacturing costs are constantly sought by End Users. Since receiving the notification of our Phase 1 success, we, PhiDrive, have been working intensively on the Feasibility Study for our project. We have analysed and planned our strategy for the future technical and business development, in order to maximize the exploitation of our innovative technology and its application within the Space industry. In this respect, we have succeded in recruiting an excellent and experience partner, Arquimea. Also, our first motor prototypes have already demonstrated the effectiveness of the technology, with the mechanical characteristics complying with the expected and desired results. Finally, our consolidated Pre2Pos business plan indicates that we will be able to sell 450 products from 2018 to 2022, bringing accumulated revenues of over €22.5 million, while at the same time creating more than 20 new positions in both companies.