RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Srp-mediated targeting of membrane proteins' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

SRP-mediated targeting of membrane proteins The aim of the project is to investigate the role of the signal recognizing particle (SRP) and FtsY, the E. coli homologues of the eucaryotic SRP and docking protein, respectively, in the targeting of membrane proteins to the cytoplasmic membrane of E. coli. Until recently, research on the targeting and assembly of membrane proteins in the cytoplasmic membrane of E. coli has completely focussed on the so-called general secretory pathway (GSP) which involves the sec-proteins. It has become clear that not all membrane proteins or domains thereof require the sec-machinery to insert properly into the cytoplasmic membrane of E. coli. This strongly points to the existence of more than one targeting mechanism for membrane proteins. Preliminary evidence strongly suggests that the SRP and FtsY are involved in the targeting of membrane proteins to the cytoplasmic membrane of E. coli.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CONSTRAINT LOGIC FOR OPERATIONAL CONTROL OF WATER SYSTEMS' (CLOCWISE) targeting Fourth Framework.

assistant: **Abstract**

The management and operational control of water systems, from drinking-water distribution to the control of industrial waste water, is a complex problem, which is mostly site- and time-specific. Traditional methods experience difficulties dealing with these problems, due to the diversity of constraints imposed (physics, chemistry, biology, ecology, public management etc.). Typically, there is a lack of complete data. As a consequence, the need for new decision-making tools coping with these complex problems is great. These tools should be flexible, easily adaptable to specific user needs and able to present fast solutions in situations where there is incomplete and imprecise knowledge.This project concerned Constraint Logic Programming (CLP), a newly emerging programming tool. Recently, CLP was successfully applied in PlaNets, which deals with operational problems in electric power-distribution networks. The similarity between power-distribution network and a water-distribution network was evident. The success of PlaNets proved that transferring this innovative technology of constraint modelling, to water-system management, offers great benefit. The success of PlaNets application lies in tight integration of constraints factors such as time, topology and electricity, yielding global solutions to a complex problem. Moreover, it proved that constraint-based computing can deal with imprecise knowledge and partial information in an efficient way.The project was an interesting example of sector to sector transfer of technology. Some of the strong elements of the project includedL- CLP software and hardware had been purchased and accepted by the end user and 3 end user engineers have been trained by the project.- through dissemination new opportunities arose; for example cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Contribution of Reactive Halogen species to the Oxidation Capacity of the Troposphere-Reactive Halogen species: cycles - mechanisms - and field observations' under Fourth Framework.

assistant: **Concept**

To study the tropospheric abundance, reaction cycles, loss processes, and effect of Reactive Halogen Species in the troposphere, in particular with respect to their influence on the total oxidation capacity of the troposphere (marine and This study is a contribution to the part of the programme dealing with the Oxidation Capacity of the  Troposphere. It will be achieved by coordinated field-, laboratory- and modelling investigations of reactive  halogen species, their precursor and storage species, and the reaction mechanisms involved. Field measurements  will include direct determination of halogen oxides by Differential Optical Absorption Spectroscopy (DOAS)  at sub-ppt levels. The laboratory studies will close many gaps in our knowledge of RHS related homogeneous  and surface-catalysed reactions including iodine chemistry. The latest data from field and laboratory studies will  be assembled in trajectory- and limited area 3D models, which will help to understand the results of the field  campaigns as well as to assess the regional and global impact of RHS chemistry. A further important part of  this study will be the assessment of a possibly anthropogenic influence on RHS sources and the transformation  mechanisms within the RHS reservoir. Thus possible mechanisms changing the tropospheric oxidation capacity  due to human activities can be investigated. While a central question concerns the importance of release of RHS  from sea salt aerosol, for instance due to reaction of anthropogenic NOy species (like N205, NO2) with sea salt  aerosol, the detailed investigation of those processes is the aim of a parallel study with the sub-title Sea Salt  Aerosols: Laboratory Investigation of Heterogeneous Halogen Activation in the Troposphere  (HALOTROP-SALT)". Areas where enha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Soot in aeronautics - towards enhanced aeroengine combustor modelling (SIA-TEAM)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

At the on sight of the expected tripling of global aircraft traffic until 2015, the corresponding pollutant emission must not be neglected. Aero engine development is highly supported by CDF code calculations to evaluate construction details with regard to their impact on combustion related parameters and emissions. Therefore, a reliable and validated soot model implemented in CFD codes offers means not only to reduce expensive rig tests, but as well to open the possibility for new combustor design concepts with the potential of reducing pollutant emissions, in particular soot. This project will deliver an Enhanced and validated mechanistic Soot Model (ESM) for kerosene like fuels. CFD codes will demonstrate their improved predictive capability using the reduced ESM combined with radiative heat transfer models under aero engine combustor conditions. The influence of the liquid phase on soot formation will be tested on its significance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Integrated microcomb system chip using heterogeneous integration'.

assistant: **Concept**

Optical frequency combs (OFC) play an essential role in precision, timing and navigation applications. Integrated photonics facilities the development of OFC-based applications towards chip-scale miniature package. Most applications require detecting the radio frequency (RF) signals of a OFC (i.e. repetition rate and carrier-envelope offset frequency). Thus, an important step towards miniaturized complex OFC systems is to integrate the OFC generation with the auxiliaries components required for detecting its RF signals onto the same chip. This project aim to develop an integrated microcomb system chip with accessible RF signals detection using heterogeneously integrated photonic platforms. Silicon nitride (SiN) platforms have shown their superiority in comb generations using microresonators (i.e. microcomb), with octave-spanning spectrum and dispersive wave emissions that enable detection of the carrier-envelope offset frequency via f-2f self-referencing process. Thin-film lithium niobate (TFLN) platforms are advantageous in second-order nonlinear frequency conversions and electro-optics modulations, the former can be applied for the f-2f process, while the latter is widely used for frequency down-converting the high-frequency repetition rate of a microcomb. Therefore, this project will explore heterogeneous integration technique to combine the SiN microcomb generator with TFLN devices for f-2f process and frequency down-conversion on a single chip. Specially, a novel photonic molecule structure will be explored for power-efficient octave-spanning microcomb generation with strong dispersive wave emission. A broadband electro-optics frequency comb will be developed for frequency down-conversion of microcomb repetition rate. Periodically poling of TFLN waveguide will be e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrical Harness and Wires Analysis and optimiZation' in the context of a Seventh Framework call.

assistant: **Objectives**

EHWAZ is a professional software solution dedicated to the sizing, analysis and optimization of electrical wire harnesses in aeronautic context. Starting from an electrical harness definition (logical and wire harness CAD-info and equipment definition), the tool checks whether harnesses comply with user-defined business rules. The harness definitions are then used to create a physical electro-thermal model (Modelica and/or C based). These models are used to simulate the transient electro-thermal phenomena in function of A/C missions and the location of the harness in the A/C. Automated post processing build map of heat flow from the harness to its environment (by branch & by A/C zone), and global results for the harness are reported by wire and by branch: weight, temperature, voltage drop, heat flow. Additionally, the electrical simulation allows plotting the current evolution, temperature and the electrical resistance over time and by wire. The voltage drop includes the current path return with respect to the A/C technology (metal, composite or hybrid). The simulation results are linked to and benchmarked with the professional rules (user-defined by integrator and/or supplier). Eventually, an optimization process is included to help the harness designer sizing and selecting the right wire. The optimization technology takes into account the multiple constraints, discrete standard aeronautical wire database. The optimization wants to achieve minimal harness weight & costs versus an electro-thermal safe, reliable & robust harness. The output of the optimization is an XML file describing the optimized harness selection in term of wire type and gauge. Besides wires optimization, the connectors are challenged to find a lighter global harness. The mechanism of professional ru
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Development of Chiral Carbon Dots for Boosting Cancer Immunotherapy'.

assistant: **Objectives**

Cancer immunotherapy is considered an effective cancer treatment strategy. However, there are still some obstacles, including the unresponsive state of the immune system to tumor antigen stimulation. In the last years, researchers have found that nanomaterials can modulate the immune system. Among many excellent nanomaterials, carbon-based nanomaterials stand out due to their good biocompatibility. Compared to the rich research on carbon nanotubes and graphene oxide, the research on carbon dots (CDs) in immunotherapy is still in its infancy. In ChiralBoost, we intend to explore the application of chiral carbon dots (Ch-CDs) in cancer immunotherapy. Ch-CDs will be synthesized by hydrothermal and microwave methods using protected L/D-tyrosine and L/D-tryptophan as precursors. Then, a tumor antigen model ovalbumin peptide and the immune adjuvant monophosphoryl lipid A will be grafted onto the Ch-CDs through post-functionalization. Next, the interaction and the immune response of the Ch-CDs on primary immune cells in vitro and in vivo, such as the ability to accelerate dendritic cell maturation and the ability to stimulate cytokine production will be explored. The generated results will open the way to explore the potential of Ch-CDs in cancer immunotherapy The conduct of this project is not only expected to the development of Ch-CDs-based anticancer nanomedicines but will also pave the way for biomedical applications of chiral nanomaterials in other potential clinical applications. The assembled research team is totally capable of achieving the ambitious objectives of the proposed project. The researcher, Dr. Hu, is a multidisciplinary researcher specializing in diverse carbon nanomaterials. The main supervisor (Dr. Alberto Bianco, Institute of Molecular and Cell Biology,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High efficiency consolidated bioprocess technology for lignocellulose ethanol', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Lignocellulosic bioethanol has the potential of contributing to a sustainable and secure European energy supply for the transport sector. European research and industry is presently among the forerunners in developing lignocellulosic bioethanol. Although a number of technical breakthroughs have been achieved during the last decade, some key technical issues especially concerning the hydrolysis and fermentation still remain to be solved. In the HYPE project, a combined approach is used to develop a novel integrated concept for hydrolysis and fermentation of lignocellulosic feedstocks. Improved enzymatic hydrolysis, fermentation of all carbohydrates, process development as well as high flexibility to feedstocks and technical robustness are among the goals of HYPE. The technologies included in HYPE will be combined into a one unit continuous consolidated bioprocessing reactor including hydrolysis, fermentation and ethanol recovery. The consolidated bioprocessing developed in the HYPE project is expected to significantly improve the overall process economy through a reduced process time, improved enzyme efficiency and high yield of all carbohydrates. Among the tasks are development of new thermophilic and efficient enzymes, C6 and C5 fermentation using F. oxysporium and modified S. cerevisiae, high dry matter hydrolysis, adaptation to various feedstocks, consolidated process development, pilot-scale testing and overall evaluation of the technical and economical potential. The feedstocks to be included in the project are lignocellulosic agricultural and forest residues. The technical development within HYPE is closely integrated with pilot-scale testing at an advanced level, thus securing commercially feasible technologies. The HYPE project will be a major contribution to Eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Charged colloidal suspensions: phase behaviour and aggregation kinetics' to be submitted under Sixth Framework.

assistant: **Abstract**

The colloidal suspensions with monovalent counter ions and salt ions will be studied by means of numerical simulations combining non-linear Poisson-Boltzmann equation (to treat the micro ionic degrees of freedom) with Brownian dynamics (for colloids). The colloidal interactions derived from the solution of the Poisson-Boltzmann equation include all electrostatic many-body interactions. With this simulation method the equation ofjstate of colloidal suspensions will be explored. The equation of state will be compared to the cell model predictions, which have not yet been validated in a broad parameter range. In case that phase coexistence will be observed, other methods, like Gibbs ensemble technique and thermodynamic free energy integration will be applied to study it in detail. Aggregation kinetics, which controls the colloidal stability, will also be studied combining the non-linear Poisson- Boltzmann equation with the population balance (Smoluchowski) equation describing the aggregation clusters population dynamics. The many-body electrostatic interactions calculated by this technique will be used to specify realistic input parameters for the aggregation kinetics, which will improve its predictive capabilities. Additionally, also a full Brownian dynamics simulation of the aggregation process (including electrostatic, dispersion and hydrodynamic interactions) will be performed. Clusters growth rate and fractal structure will be analyzed and their relation to the underlying interactions will be explored. The proposer will cooperate with experimental groups in Graz and Stuttgart in planning, performing and evaluating experiments on aggregation in 2D (by means of video microscopy arid laser tweezers) and in 3D (by means of light scattering). The combination of experiments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High performance Monte Carlo reactor core analysis' (HPMC).

assistant: **Innovation**

Design and safety analysis of nuclear reactors is based on extensive use of computer codes for the coupled calculation of time-dependend neutron transport, thermal-hydraulics and burnup.State-of-the-art methods use deterministic techniques to solve the neutronics equations, which require various approximations for a full core:a limited number of energy groups, application of diffusion theory instead of transport theory, homogenization of fuel cells and fuel assemblies, pin power reconstruction, etc.These approximations can be overcome by the stochastic Monte Carlo method for neutron transport.However, coupling with thermal-hydraulics codes, long-time time dependence and application to full reactor cores for detailed (pin-by-pin) power density distribution is only at its infancy.The project aims at developing and demonstrating the application of full core Monte Carlo calculation for time-dependent safety analysis with thermal-hydraulic feedback and burnup using high performance computing.Although Monte Carlo calculations are very suitable for parallel execution, full core integrated problems require ultimate efficiency in parallel execution of the Monte Carlo calculation itself and complete optimisation of all coupling mechanisms when run on a supercomputer with large numbers of processors.The project will provide the general tools  for reference calculations, applicable to different reactor types, to test the accuracy of current and future deterministic analysis methods.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Limits of discrete structures' in the context of a Seventh Framework call.

assistant: **Objectives**

Built on decades of deep research in ergodic theory, Szemeredi's regularity theory and statistical physics, a new subject is emerging whose goal is to study convergence and limits of various structures.The main idea is to regard very large structures in combinatorics and algebra as approximations of infinite analytic objects. This viewpoint brings new tools from analysis and topology into these subjects. The success of this branch of mathematics has already been demonstrated through numerous applications in computer science, extremal combinatorics, probability theory and group theory. The present research plan addresses a number of open problems in additive combinatorics, ergodic theory, higher order Fourier analysis, extremal combinatorics and random graph theory. These subjects are all interrelated through the limit approach.