RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Predicting the Future of Island Biodiversity: Integrating Traits to Decipher Species Turnover Dynamics' under Horizon Europe.

assistant: **Concept**

Global change is altering vegetation, with climate zones shifting poleward and species distributions changing. Rising sea levels, land-use change, and invasive species further modify natural vegetation, leading to the reassembly of native communities. However, the rates and patterns of community changes across different vegetation types, along with their consequences for biodiversity, remain unclear. This proposal explores the effects of global change on coastal islands and mainland habitat fragments using resampled vegetation data. Islands, which support unique biodiversity and are particularly threatened by rising sea levels and invasive species, serve as models for understanding the effects of fragmentation on the mainland. The overarching aims of this proposal are to: (i) advance island biogeography by characterizing plant ecological strategies on islands through functional traits, focusing on immigration and extinction dynamics; (ii) describing potential futures under global warming; (iii) compare assemblage dynamics on islands with those in fragmented mainland habitats; and (iv) synthesise findings towards effective conservation strategies for coastal island vegetation. The strengths of this proposal include its focus on islands as simplified systems, the use of a unique dataset with resurveyed vegetation, and the synthesis of findings from both island and mainland habitats. Understanding differences between island and mainland assemblages will be key to predicting the future of island ecosystems.


**Keywords:** global change biology, functional ecology, island biogeography, plant ecology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative casting process of lighter steel components for the transport industry' (ICARO) targeting Fourth Framework.

assistant: **Abstract**

In the project period the following outputs were achieved:* Material properties and specification for the automotive and aeronautical applications.* Material selection. * Ingots of selected material.* Detailed characterization of alloys * Selected components and its specifications.* Detailed simulation tests.* Design of laboratory experiments/preliminary laboratory results.* Laboratory experiments data for the numerical model implementation.* Implemented numerical model.* Production of pure PMMA L-F patterns.* Production of crankshaft and rib castings.* Introduction of cast-in oil channels.* Fill monitoring of the state-of-the-art casting clusters.* Environmental investigation of the L-F pattern degradation products.* Cost benefit analysis.* Mechanical and micro-structural characterisation.Objectives and content The overall object of this project is to develop an innovative casting technology for manufacture near net shape steel components, compatible with the mass production requirements of transport industry. The proposed approach for reaching this target, is to advance the Lost Foam technology for its application to steel. Lost Foam technology can be considered to be satisfactorily developed for aluminium alloys and cast iron, becoming more and more widespread due to its advantages in comparison with other technologies. The possible extension of Lost Foam casting to steel grades represents a great technological innovation and a very attractive industrial goal due to the following reasons. At present time the most widespread forming processes for steel are stamping for sheets and forging for massive parts; the steel casting technologies, till now available, are not diffused in the transport industry mainly because they are not cost competitive and/or not compatible wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Chemistry and microphysics of Contrail formation'.

assistant: **Innovation**

The chemistry and microphysics of contrail formation of modern turbojet aircraft engines will be studied using a combined approach of experiments and model calculations. The detailed objectives of this proposal are - To improve the mechanism of pollutant formation in both the engine nozle andthe jet regime of the plume with particular emphasis on those componentsthat are involved in contrail formation (SOx, HOX, NOy and soot) - To characterize the chemical and microphysical properties of aircraft enginesoot particles after emission and during ageing under simulated plumeconditions. - To refine existing unmerical codes treating homogeneous and heterogeneousnucleation by including non-equilibrium effects and soot activation kinetics. The proposal is suggested to be carried out in three different work packages - WP1: Modelling of HOx, NOX and SOx chemistry in gas turbine and nozle regionmeasurements. - WP2: Physical and chemical characterization of engine emitted sootparticles. - WP3: Modelling of homogeneous and heterogeneous nucleaction. The participants of this project originate from both the experimental (engine emisssion and laboratory studies) and modelling (chemistry and microphysics) community with extended individual expertises. It is therefore expected that CHEMICON will be conducted successfully and that its results contribute to an improved understanding of contrail formation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reprogramming cell identity to develop new therapies against Cholangiopathies' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Intra- hepatic Cholangiocytes represent one of the main cell type of the liver with hepatocytes. They line the biliary tract and fulfill essential functions such as bile modification and transport. Cholangiocytes are targeted by a diversity of diseases including genetic disorders such as Cystic Fibrosis. There is currently no cure for disorders affecting cholangiocytes and end stage disease require liver transplantation. Importantly, primary cholangiocytes obtained from biopsy can not be grown in vitro without loosing their functional characteristics while transformed cells and animal models rarely recapitulate the entire pathophysiology of human diseases. Consequently, the development of novel drug and therapies remains problematic despite an urgent clinical need. Human induced pluripotent stem cells could provide an advantageous solution to bypass this major challenge. Indeed, these pluripotent stem cells are generated by direct reprograming of somatic cells and they can proliferate almost indefinitely in vitro while maintaining their capacity to differentiate into almost any cell types. Interestingly, hIPSC can be derived from patients with genetic disorders and then differentiated into the relevant cell types for disease modeling purposes. Of direct interest, we recently developed a protocol to generate cholangiocytes from hIPSCs using chemically define conditions. The resulting cells display functional characteristics of their in vivo counterpart including the capacity to transport bile acid. Here, we propose to enable our culture system for the production of  large quantity of hIPSCs derived cholangiocytes in conditions compatible with the pharmaceutical industry requirements. The resulting cells will be then fully characterized to validate their relevance for mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Probing Histone Acetyl Transferase Function by Directed Evolution'.

assistant: **Innovation**

The DNA of eukaryotic cells is packaged in chromosomes located in the nucleus. The fundamental package unit of DNA are nucleosomes, which are composed of an octameric histone core that is wrapped with DNA. Over the last few years a wide variety of post-tra nslational modifications of these histone proteins have been linked to essential biological processes. This is particularly true of histone acetylation, by enzymes called histone acetyl-transferases (HATs). Acetylation of lysine residues can activate gene transcription, whereas conversely deacetylation is linked to gene repression. Thus, the modification of histones in chromatin plays a central role in transcription regulation. Currently the dissection of the roles of individual modified histone lysine resi dues is limited by low activity and/or specificities of isolated/recombinant HATs. We propose to combine directed evolution with biochemical and in vivo assays to understand the functional consequences of modifying specific histone lysine residues. We will use natural HATs as starting points to evolve novel HATs that have enhanced activities and altered specificities. These engineered HATs will be used to generate histone with specific acetylation patters, which will permit reconstitution of defined chromat in templates to probe the biological function of histone acetylation in detail.The proposed research project will lead to a better understanding of how chromatin modification and physiological responses are related. This knowledge is instrumental to fully understand how eukaryotic organisms turn on and off gene transcription by chemical modification of histones. Thus, the proposed fellow will contribute to EU scientific excellence by starting a new area of research in the field of chromatin function. Detail ed i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Early-life URBAN environmental exposures and childhood multimorbidity: An Exposome-wide approach' in the context of a Horizon Europe call.

assistant: **Objectives**

URBANE addresses an important and timely question: how does the urban environment impact the developmental origins of multimorbidity? Neurodevelopmental, cardiometabolic and respiratory adverse health outcomes are increasingly prevalent at young ages, with diseases such as obesity and asthma affecting up to four out of ten children in Europe. Multimorbidity, the co-occurrence of two or more health conditions, in childhood is thus becoming a major public health problem with short- and long-term consequences. Although it is well known that environmental hazards play a role in the development of diseases, the contribution of the complex environment in which we grow up and live on the development of multimorbidity remains unclear. URBANE addresses this knowledge gap. The project will leverage the resources of the Portuguese population-based birth cohort Generation XXI and follow an exposome-wide approach to the study of urban environmental impact on childhood multimorbidity. For that, the project will use a wide range of geospatial urban exposure data (e.g., air pollution, and characteristics of the urban natural and built environment) and multiple adverse health outcomes (e.g., high blood pressure, obesity, asthma, behavioral problems) collected at the vulnerable early stages of the lifecourse (pregnancy and childhood). The project will explore socioeconomic status and gender differences and also assess whether DNA methylation changes and dysregulation of hormone leptin explain the urban environmental impact on multimorbidity. URBANE will contribute to the discovery of urban environmental priorities, vulnerable subpopulations and aid in the identification of underlying mechanisms. URBANE is highly interdisciplinary, and fosters knowledge exchange. The project aligns with m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Riemann-Roch and motives for arithmetic problems'.

assistant: **Concept**

Our project “Riemann-Roch and Motives for Arithmetic Problems” aims to develop techniques in the area of Motives and the Riemann-Roch to attack arithmetic problems. To be more concrete we aim to attack:- The integral Riemann-Roch: At SGA VI Grothendieck developed his landmark Riemann-Roch result stating an integral version of it as an open question. Later on, research of Fulton, MacPherson and Pappas raised Grothendieck original conjecture to a more complete statement related to traces, which is known today only in the complex geometric setting. We aim to prove this conjecture in its full generality. -The discrete Riemann-Roch: At SGA5 Grothendieck proved his wellknown Ogg-Shafarevich formula computing the Euler characteristic of a constructible sheaf over curve in terms of the genus, the Swan conductor and therank. This formula plays a central role in the original strategy to prove the Weyl conjectures. Grothendieck also conjectured that this formula would fit into a Riemann-Roch type theorem for the K-group of étale constructible sheaves and general schemes, which he called the “discrete Riemann-Roch”. We aim to attack this theorem from the motivic point of view.-Intersection theory in the arithmetic setting: A major objective of Algebraic Geometry is to define a product algebraic cycles forin the arithmetic setting. So far, this product has being defined with rational coefficients. The first definition, due to Gillet-Soulé, was achieved throughout the Adam’s operations, the Adams Riemann-Roch and theGrothendieck-Riemann-Roch. We aim to explore some of Gillet-Soulé’s ideas and the arithmetic bivariant integral version of the Riemann-Roch to explore a definition of the intersection product of cycles after killing certain torsion on the Chow groups related to the codime
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Survival of Sulfuric Acid Clouds in the Terrestrial Planet Climate: From Earth to Venus to Exoplanets' (SoSAD) under Horizon Europe.

assistant: **Objectives**

Sulfuric acid clouds (SAD) play an important role in the Venus, Earth and potentially exoplanet climates. However, a systematic understanding of SAD's life cycle within terrestrial planetary evolution is still lacking. Here I propose a project that aims to understand the emergence, sustainability and extinction of SAD in the climate evolution of terrestrial planets (Objective 1), and evaluate the SAD radiative, cloud-physics and chemical feedbacks on the planetary climate evolution in a geological timescale (Objective 2). I will combine my expertise in clouds and chemistry with the supervisor's expertise in radiative transfer and exoplanet atmospheres to construct the first 1D state-of-the-art geochemistry-climate evolution model with a complete sulfur cycle included. First, I will use the model to determine the planetary environments required for SAD to emerge and exist for a long term, and to investigate the long-standing question of why Earth and Venus evolved in a divergent way. Then, I will use my new model to resolve and study the radiative, cloud-physics and chemical feedbacks of SAD on planetary climates, and investigate whether SAD's lifetime is also affected by these feedbacks. Finally, I will apply my model to exoplanets observed by the “Hot Rocks"" JWST survey to explore the possibility of SAD's existence on terrestrial exoplanets. I will accomplish the objectives and contribute with broad, long-term impacts to both the Venus and Exoplanet communities, considering that three upcoming Venus missions, JWST and other space telescopes are or will be providing more observations of terrestrial planets. Through the MSCA programme, I will also establish my leadership in the interdisciplinary research community and transition from an independent researcher to a group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DNA Infrastructure for Storage and Computation' (DISCO) under Horizon Europe.

assistant: **Objectives**

Throughout evolution, Biology has found an almost-perfect molecule to pass information down through the millennia.  Whether for a simple bacterium or the largest whale, DNA achieves high information density while permitting cellular machinery rapid random-access retrieval to decode everything from a single protein to the development of an entire human brain.  Humanity's rapidly-growing data storage and computing needs make it is tempting to exploit optimised biological molecules and processes, but biology is messy, poorly-understood and much more specialised for life than it is for our needs -- we propose to use DNA for storage together with a rationally designed, well-characterised and robust molecular computing architecture.The DISCO project will address the challenge of engineering a programmable and robust DNA storage and computing platform.  DISCO combines powerful molecular-algorithmic ideas from DNA computing with notions of thermodynamic stability from DNA nanostructures, to provide an expressive and robust system design.  The project proposes the use of long DNA scaffold strands, upon which hundreds of smaller strands bind to store data, which can be later read, erased, rewritten and computed upon.  DISCO begins with the aim of trialing a small, but thoroughly characterised and modelled prototype, that facilitates storage and computation on 10 bits.  Then, DISCO will scale-up the system to hundreds of  bits by leveraging recent technological advances to enable high-throughput techniques at both the experimental and data-readout stages.  Finally, DISCO will be extended to two-dimensional DNA origami structures, each carrying about a hundred bits, but with millions of structures in the same test tube, exhibiting DNA storage and computation in a distributed system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fine genetic structure of swordfish (Xiphias gladius) in the Mediterranea and the Atlantic: Study by means of individual genetic tagging, using microsatellite DNA markers.' (SWORDGEN).

assistant: **Innovation**

The objective of this study is to substantiate the pattern of geographical distribution of the three swordfish stocks in the Atlanto-Mediterranean region, the existence of which was evidenced by mtDNA analysis (Chow et al. 1997, Mar.Biol., 127,359-367). More specifically, it will be sought to estimate the extent of population mixing of these stocks in the feeding grounds (north and south Atlantic), and to estimate the levels of gene flow between them. Special attention will be paid on the Mediterranean stock, which as strong evidence suggests, should be considered as an endangered population. We propose to describe the migration and distribution patterns of the three stocks in the feeding grounds of the Atlantic, to check for a within Mediterranean sub-structure by genetic characterization of eggs and/or larvae, or juveniles, and to study variation in gene frequencies between different generations in the Mediterranean. As very little is known on the distribution of the Mediterranean stock in the feeding grounds of Atlantic, it is impossible to correlate a specific fishing pressure in this area with the observed response of the Mediterranean stock. The presently proposed project could give the information needed, by intensive sampling and assignments of specimens to differentiated groups on the basis of their combined genotypes on three to five microsatellite markers (already developed and proved efficient). The reference material on the basis of which fished animals all around the Atlantic will be classified, will be constituted by samples from the three main spawning grounds (Mediterranean, Gulf of Mexico and Tropical Atlantic).This project can constitute the base for future monitoring of swordfish populations, by the creation of a databank with genetic and biological