RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Consumer concerns about animal welfare and the impact on food choice' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The aim of this project is to assess the nature and magnitude of consumer concerns about animal welfare within a cross-section of EU member states (United Kingdom, Ireland, France, Italy, Germany) and the potential impact on choice of animal-based food products and suggest strategies by which consumer concerns can be addressed. In particular, the project will:Identify the nature of consumer concerns about animal welfare within across section of EU member states;Assess the differences and the similarities in consumer concerns about animal welfare, between consumers both within and across EU member states;Identify the relationship between consumers concerns about animal welfare and the methods used to rear and transport animals;Assess the knowledge of consumers about the actual practices employed to rear and transport farm animals;Assess the trade-off between animal welfare, price and other product characteristics in choice of animal-based food products;Assess the impact of changes in the methods used to rear and transport animals on the potential choice of animal-based food products;Identify strategies which can potentially address consumer concerns about animal welfare.There is evidence that consumers across the EU are increasingly concerned about the welfare of animals produced for human consumption and that such concerns affect their choices of animal-based food products. However, to date there has been little meaningful research on the nature of consumer concerns about animal welfare and how such concerns differ within and across EU member states.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The atm gene in breast cancer and radiation sensitivity' (1998-2002).

assistant: **Innovation**

----------------Reference about Dr. Sara Gutiérrez I have known Ms Sara Gutiérrez since 1993, year in which she started the Doctoral Programme in Genetics, in the Department of Genetics and Microbiology of the UAB. The programme included 32 credits over a period of two years and 9 credits may be obtained with a research project. Sara was one of the best postgraduate students in the courses of Mutagenesis and Genetic Toxicology and she completed an interesting Master Thesis on the First data on the cytogenetic biomonitoring in a group of patients treated with the radioisotope 131I", achieving a good training and an excellent mark. During the doctoral period, Sara displayed a good knowledge of genetics, mutagenesis, molecular and cell biology, and genetic toxicology, in both fundamental and practical fields , which enabled her to design experiments and complete them with success. Over this period she worked extremely hard and performed high quality experiments, which results have been published in various prestigious scientific journals, as indicated in her curriculum vitae. In the course of these experiments she mastered several new techniques and learnt a great deal about cell cultures, mutagenesis, and genotoxicity testing. Moreover, she has always been able to explain and discuss her results clearly in conversation, seminars and meetings. Last December Sara presented her Ph.D. dissertation Thesis in the School of Biological Sciences of the Universitat Autònoma de Barcelona (UAB) on "Biomonitoring of patients treated with the radioisotope 131I" , obtaining the mention CUM LAUDE. With reference to her knowledge of cytogenetic techniques using human lymphocytes, she knows the assays for chromosome aberrations, sister-chromatid exchanges and micronuclei very well. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'time-like observables from multi-level lattice QCD'.

assistant: **Concept**

Lattice Quantum Chromodynamics (LQCD) is the only known systematic framework to obtain ab-initio results in the non-perturbative regime of strong interactions. Its relevance to high-energy and nuclear physics has grown significantly in recent years due in part to a series of algorithmic advancements.This project aims to compute time-like observables using numerical simulations of LQCD. Specifically, I will study spectral functions including the R-ratio, that is linked to the hadronic vacuum polarization of the electromagnetic current, and the hadronic tensor, that contains information on deep-inelastic scattering.It is extremely challenging to compute observables intrinsically defined in Minkowski spacetime with lattice techniques, with the main issue being that the simulated quantum field theory is defined in Euclidean spacetime. While Euclidean correlators contain all the information needed to extract real-time physics, performing the analytic continuation with finite-precision data points from numerical simulations is an ill-posed problem. A second issue is that the the computational cost is driven by the loss of the signal of hadronic correlators with Euclidean-time separation, that happens at an exponential rate.I will address these issues and significantly reduce the computational effort needed thanks to algorithms advancements. I plan to solve the signal-to-noise ratio problem using and further developing multi-level Monte Carlo sampling methods, that I recently contributed to extend to theories with fermions. The resulting exponential gain in the quality of the signal is essential to be able to perform the analytic continuation, that I plan to control using state-of-the-art techniques based on the Backus-Gilbert algorithm that have recently been developed by the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A microfluidic cryofixation method for time-resolved correlative microscopy' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Correlative microscopy, connecting live-cell fluorescence microscopy with electron microscopy (EM), is a powerful tool to relate a dynamic cellular process to the relevant cellular ultrastructure leading to better understanding of fundamental mechanisms, and further, the underlying cause of disease. This is not only important for fundamental science but can guide diagnostic and treatment efforts for virtually any affliction, ranging from Alzheimer’s disease, to HIV, to cancer.  In this work, I propose a novel microfluidic cryofixation method that enables time-resolved correlative microscopy. The new method dramatically improves the time resolution with which live images can be correlated to EM images by eliminating the need to transfer the sample from the light microscope to a dedicated cryofixation machine. Current state-of-the-art systems require at least one second while preparation times up to a few minutes are common. Here I propose a new microfluidics-based paradigm that will overcome this barrier by carrying out cryofixation directly within the field of view of a light microscope. This method allows a dynamic process to be arrested at a known time, so that it can be correlated to cellular ultrastructure in EM images. This new method is a critical advance for studying dynamic processes such as membrane trafficking, cell division, and synaptic transmission. This action opens vast possibilities for multidisciplinary collaborations between microfluidic and engineering specialists, who developed a new method (Burg group), and experts in microscopy for biological sciences (i.e. within histology, cell biology, structural biology) to advance the fundamental understanding of dynamic cellular processes that occur on the time scale of milliseconds. Through this multidiscipl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'COMponent Based INteroperable enterprise system development' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The vision of the COMBINE project is one of component-based systems that are easy to build and deploy, and which support scalable enterprises in highly dynamic environments. The goal of the project is to develop user-driven and simple methods and tools for modelling, developing, and building component-based systems. The methods and tools support efficient development, deployment and execution of components, and dynamic solutions for providing and presenting services and information. The scope of the project is to apply a requirements-driven and user-driven approach based on development of solutions related to the requirements of the user-pilots and demonstration of solutions in that context.Objectives:The overall goal of COMBINE is to support model-driven development of enterprise systems - using Components. This requires further development of methods, infrastructures and tools as well as business solutions for modelling, designing, deploying, testing and running components successfully in an enterprise-wide scale.COMBINE shall provide:(1) Modelling of components for the enterprise;(2) Tools that aids the design and implementation of these components;(3) Tools that aids the deployment and running of these components in the enterprise;(4) Infrastructure support that provides flexibility of service, information handling and presentation, and;(5) An analysis of the techniques and methodologies necessary to successfully verify the implementation and conformance to standards of these components.Work description:The main work items that are anticipated to be performed as part of the COMBINE project include but are not limited to:* Development of cohesive component concepts that are independent of any particular technology, that address granularity questions, and that apply t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Targeted microbubble vibrations to accurately diagnose and treat cardiac device-related bacterial biofilm infections' to be submitted under Horizon 2020.

assistant: **Abstract**

Due to an aging population, increasingly more cardiac devices are implanted (pacemaker/ICD/CRT/ prosthetic valve/LVAD; worldwide ~2 million yearly). Life-threatening bacterial infections (1-60% infection and 29-50% mortality rate) associated with these devices are a major healthcare burden and pose scientific challenges. Ultrasound imaging is currently the primary diagnostic modality. However, it lacks specificity and sensitivity because the signal from the bacteria is similar to the signal of healthy tissue or the cardiac device, thus making accurate diagnosis impossible. Recent developments in targeted ultrasound contrast agents (i.e. targeted microbubbles (tMB), 1-8 micron in size) allow ultrasound imaging of a specific tMB vibration signal resulting in exceptional sensitivity and specificity. Advancing tMB imaging to detect bacterial infections is needed to solve the challenges caused by the complex ultrasound field from these devices. I was the first to show that vibrating tMB induce vascular drug uptake, thereby showing the potential of tMB as a theranostic agent by combining imaging with drug delivery. Recently, my team and I were also the first to demonstrate which tMB vibrations kill vessel wall cells in vitro by developing analysis methods that link tMB vibrations to drug uptake patterns on a single cell layer. As this is the first time this technique will be applied to 3D bacterial biofilm infections on cardiac devices, I will go beyond the state-of-the-art in tMB-tissue interaction technology by developing novel detection, analysis, and modeling methods to accurately determine which tMB vibrations eradicate bacterial biofilm infections on devices. The Bubble Cure project will result in a novel multidisciplinary technology that allows accurate diagnosis and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Bichromatic Structures for Robust propagation of Light'.

assistant: **Innovation**

The investigation of topological effects in photonic systems is a thriving field of research in the nanophotonics community. Suitably designed nanostructures allow the formation of novel states for light which are more robust against disorder and less sensitive to back-scattering, spurring academic fascination and helping to improve photonic circuitry technology. Recent advances have greatly expanded the variety of systems displaying topological effects: for instance it has recently been shown that the Aubry-André model, a one-dimensional tight-binding model of particles with a periodically-modulated on-site energy, inherits the nontrivial topological properties of a higher-dimensional topological insulator.In this Action, I propose to create a photonic realization of the Aubry-André model for near-infrared light with photonic-crystal structures and demonstrate, both theoretically and experimentally, the emergence of nontrivial topological properties. To reach this goal, I will theoretically develop the concept of “bichromatic” photonic crystals, i.e., dielectric structures with a specific spatial arrangement of the refractive index characterized by the superposition of two incommensurate periodicities. Such structures have the potential to combine topologically-protected propagation of light with the strong enhancement of light-matter interaction characteristic of nanostructured fields. Topological effects will be revealed by the formation of boundary states at the edge of the structure, which will be experimentally visualized with near-field scanning microscope measurements. The spectrum, the topological invariants, and the effect of nonlinearities will be thoroughly investigated. This Action will give me the opportunity of directly supervising an exciting research pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Prevalence, 1-year incidence and symptom severity of mental disorders in the elderly: Relationship to impairment, functioning (ICF) and service utilisation' under Seventh Framework.

assistant: **Concept**

Reliable data on the prevalence and incidence of the spectrum of mental disorders in older people are currently lacking for the EU. Despite the availability of some national and a few cross-national cross-sectional studies with quite variable results, the size and burden of mental disorders in the elderly remains unclear. This has been attributed to a number of methodological factors (e.g. lack of appropriate diagnostic instruments). In addition patterns of incidence and of the natural course and prognosis of mental and physical disorders in people above 65 years are lacking nationally and cross-nationally in the EU, with only a few notable exceptions. Furthermore, there are no cross-national studies investigating the interaction of mental disorders and the utilisation of treatment under specific consideration of the severity and the impairment of activities and participation, in terms of ICF-categories, of older people in different European countries. Therefore, the objective of the proposed study is to (1) develop, respectively to adapt existing instruments and (2) to collect data on the prevalence, the incidence and on the natural course and prognosis of mental disorders, and to do this in sufficiently powered representative samples of older people living in the community across different European countries. This includes assessing health service needs, investigating to what extent existing services are used by older people and which specific barriers to utilisation may exist. Thereby, the implementation of the study will enable the further development and improvement of harmonised instruments for the assessment of impairments of activities and participation in older adults, to adapt already existing instruments, and to facilitate results that are comparable across c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Composting as a post-treatment method to mitigate the transfer of antimicrobial resistance and spore-forming Firmicute into the food chain (RESISPORE)'.

assistant: **Objectives**

The use of animal waste as agricultural fertilizers is a potential source of pathogens, antibiotic resistance genes (ARGs) and antibiotics residues (ABs) and must be managed accordingly. Pre-treatments of organic waste prior to land application offer the potential to abate enteric bacteria, and therefore reduce the risk of contamination of crops or adjacent water resources with resistant pathogens carried in these materials. However, the reduction and fate of such fecal indicator bacteria may not properly predict the responses of of all types of pathogens, especially those that produce spores. The inactivation of spore-forming pathogens, such as Clostridium and Bacillus spp., from animal waste could be challenging given the recalcitrance of the spores these bacteria produce. RESISPORE is an interdisciplinary and innovative project in the field of environment & agriculture that aims to identify intervention management strategies to stop the initial movement of antimicrobial resistance (AMR) and spore-forming pathogens from animal waste into the environment and food chain. RESISPORE aims are aligned with current European strategies to produce safe, healthier, and more sustainable food such as The Farm to Fork strategy or the EFSA recommendations for protecting food safety. This project will be delivered by the fellow Dr. Jessica Subirats, with a strong expertise in environmental microbiologist, under the supervision of Dr.Victor Matamoros, who has a strong track-record in environmental biochemistry and agricultural science. The fellowship will provide new expertise and training on analytical chemistry, large-scale biogas operations, agricultural science, and professional development for academics. The fellow will bring her knowledge of AMR and microbiology using both cult
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dividing Powers among People(s): Towards a New Federal Theory for the 21st Century' (NEO-FEDERALISM).

assistant: **Innovation**

How should political power be divided within and among national peoples? Can the nineteenth-century theory of the sovereign and unitary State be applied to the social reality of the word of the twenty-first century? If not, what constitutional and philosophical theories can make sense of the empirical and normative world of our times? The rise of international organizations and, within Europe: the emergence of the European Union, have challenged the idea of the sovereign state ever since the end of the Second World War. And, in a seemingly paradoxical parallel, the myth of monolithic state power has equally come under attack from within states. Indeed: many modern states currently experience a political and constitutional devolution (Italy, Spain, United Kingdom).Can we identify these developments with federal theory? Federalism is a philosophical and a constitutional problem. The federal principle has made a long ‘journey through time in quest of a meaning’ (SR Davis). Modern federalism emerged with the rise of the European State system. And in the nineteenth century, the federal idea became reduced to the idea of the Federal State. In the light of this reductionism, international centralisation and regional decentralisation continue to be – largely – misunderstood by mainstream European legal scholarship. The proposed project would fill this gap by providing a comparative constitutional analysis of the federal principle. It will analyse the historical evolution of the principle from the eighteenth to the twenty century in the first part, and concentrate on three contemporary experiences of “dividing” or “sharing” sovereignty in the second. The three case studies of (neo)federalism in the 21st century correspond to three legal sphere: the international sphere (United N