RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The effect of retinoic acid on the fate of γδ T cells' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Retinoic acid, the active metabolite of vitamin A, is implicated in a broad range of well-studied pre- and post-natal functions. By comparison, its involvement in the development and function of the immune system remains largely unknown. However, it has recently been shown that retinoic acid has a protective effect in a murine model of colitis by switching the cytokine production by γδ T cells from pro- (IL-17A) to anti-inflammatory (IL-22). At the border between innate and adaptive immunity, γδ T cells constitute an important part of the immune system and are highly involved in the pathogenesis of several autoimmune or infectious disorders. Although these cells are found throughout the immune system, they can be divided into subpopulations which are interestingly enhanced in the compartments located at environmental interfaces such as the skin, intestine, uterus and lungs. Throughout this fellowship, I propose to (1) study the molecular mechanisms by which retinoic acid is able to change the fate of γδ T cells, (2) analyze the differential impact of retinoic acid between the γδ T cell subtypes, and (3) study the influence of retinoic acid in vivo, in two different autoimmune disorders, psoriasis and experimental autoimmune encephalomyelitis. This study will highlight γδ T cells as new therapeutic targets and retinoids as immunomodulators for the development of efficient immunotherapies, a highly promising challenge in medical research for the future treatment of cancers, autoimmune and infectious disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INtelligent MObile Video Environment' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Considerable technical advances are currently been taken in mobile and wireless networks and terminals. The forecasts by market research institutes (e.g. IDC) predict an impressive market share for the available and upcoming GPRS and 3G terminals. Higher bandwidths combined with improved terminal capabilities (e.g. high processing power, high quality displays and long battery life) will enable new services to be delivered to users with intelligent multimedia terminals in their pockets.The new attractive technological framework does not, however, guarantee the user acceptance.The success in this respect depends heavily on the availability and affordability of well designed, implemented and tested multimedia services in relevant application areas. The mobile environment is particularly demanding with respect to audio-visual applications. Current services have not made much impact on the market because of their low quality of video, weak reliability, high prices and minor utilities.Although mobile IP and IPv6 ease the implementation of new mobile applications with rich content, typical obstacles still remain, such as low bit rates, burstiness and delays, as well as the limited memory and processing power of mobile terminals. Streaming of multimedia information, including optimised solutions for multiplexing and synchronisation, is an area that still needs particular attention. In addition to these obstacles, the general heterogeneity of mobile channels and terminals further challenges the development of successful services.A fundamental step in establishing new, intelligent, multimedia-rich services for mobile users is the provision of a common technology base. This will lead to concrete applications and services with strong potential appeal to a large customer base.The IN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The evolutionary genetics of virulence: host-pathogen interactions in Daphnia magna' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

At some point in their life all animals will be challenged by the threat of infectious disease. How an animal copes with pathogens will depend on their ability to resist infection or to minimise the virulence of disease once a pathogen has invaded. Accordingly, understanding the mechanisms behind the defence against infection and virulence has been a major goal of not only evolutionary biologists interested in host-pathogen interactions, but also epidemiologists involved in public health considerations and agriculturalists attempting to minimise the impact of pests. However, despite the importance and widespread occurrence of host-pathogen interactions, very little is known about the genetic architecture underlying the different lines of defence that animals use to prevent infectious disease. I propose a research program that will examine the evolutionary genetic basis of host-pathogen interactions in the crustacean Daphnia magna and its bacterium pathogen Pasteuria ramosa. To do so I will take advantage of a newly developed, high coverage quantitative trail loci (QTL) panel to quantify the genomic basis of virulence in this species and the potential role that the host-immune system has in defence against infectious disease. I will also use a novel experimental evolution approach to explore the co-evolutionary link between the ability of a host to resist infection and the resulting severity of disease. This innovative blend of my expertise in evolutionary manipulations and multivariate statistics with the new challenge provided by state of the art genomic techniques, will allow for considerable advances to be made in our understanding of how host and pathogen genomes interact to influence infectious disease. Moreover, by integrating aspects of evolutionary genetics, gen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Secure Multiparty Computation in the von Neumann Architecture'.

assistant: **Innovation**

The ultimate aim of this project is to design and implement an efficient virtual machine that can be used in practice for generic secure multiparty computation (MPC).MPC is a way to convert any distributed computation that can be performed securely with the assistance of a trusted third party into a protocol that does not require any third parties, yet gives the same output and remains just as secure.The existence of MPC is one of the breakthrough results of modern cryptography. These results appear to be extremely relevant for problems in many areas - wherever there is tension between privacy, trust and functionality. In practice, however, there is very little real-world use of these techniques.Existing MPC techniques involve translating a function to be computed into a logical circuit. This architecture has some drawbacks, however, that we believe contribute to the scarcity of real-world use of these techniques. In particular, programs whose running time is potentially very long are infeasible to implement as circuits (since a circuit's size depends on the maximal running time of a program). Moreover, there are far more engineers familiar with programming than with the constraints of circuit design.In this project we propose to take a new approach to practical MPC: changing it from a ``hardware engineering'' problem (designing circuits) to one of ``software engineering'' (writing programs). The high-level idea is to develop a ``secure computation virtual machine'' in the von Neumann architecture: a virtual CPU and virtual RAM that can run programs in a similar way to a modern physical computer system. Such an architecture would allow secure programs to be compiled directly from standard programming languages (such as C or Java). The hope is that, once such a system ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Experimental quantification of physico-chemical processes in Campi Flegrei tuff' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The study of volcanoes is one the key themes within the EU natural hazards research agenda. This study will aim to improve the existing forecast models by investigating fundamental deformation processes in volcanic tuffs from the Campi Flegrei area. This area is characterised by peculiar ground deformation episodes whose origin is not well understood.Field monitoring of such events has revealed that both geochemical and geophysical parameters change during the deformation episodes. I propose to study the fundamental mechanisms that could generate these phenomena by carrying out a unique set of cross-disciplinary laboratory experiments on the tuffs. The tests will be carried out in the presence of water and under a stress state that simulates the in-situ conditions in the crust.I will quantify the extent of water assisted deformation processes and the associated time dependent strength reduction in the tuffs. I will also monitor various geochemical and geophysical parameters during each test. The laboratory data will be compared with the field data in order to gain a better understanding of the origin of the deformation events.The experimentally defined values will also provide input data for numerical models of the subsurface system at Campi Flegrei. The results of this novel experimental programme will advance our knowledge of the physical mechanisms that may be responsible for the time-dependent uplift-subsidence sequences in this volcanically active area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Micromachined and optical systems using thin oxide films' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main aim of this programme is to increase and improve the functionality of micromechanical components by using the piezoelectric and pyroelectric properties of PZT thin films. To widen their range of applications these materials will be incorporated for the first time into a micromachined gyroscope, a piezoelectric pump, and an optical switch for a planar waveguide. A resonant thermal sensor, incorporating PZT in a novel geometry, will also be developed. The combination of recent technology developments in silicon micromachining with those in PZT thin film deposition provides an opportunity to realise a new range of miniature sensors. PZT processes will be optimised by studying the piezoelectric and pyroelectric properties of thin films deposited on materials and structures that will be used in the demonstrators. These results will be used as input for the demonstrator design. Different PZT deposition techniques will be optimised to produce both thin (<0.3 mm) and thick (>5 mm) films. Silicon micromachining techniques, including deep reactive ion etching, will be developed to produce resonating structures out of single crystal silicon with a high mechanical Q. For the thermal and optical demonstrators, electrodes will be developed that are both electrically conductive and optically transparent. Techniques of encapsulation and interconnection will be developed that allow the demonstrators to achieve the optimum performance permitted by this new technology. The use of thin film piezoelectric material deposited on micromechanical oscillating elements is an attractive means of simplifying device designs. The design of the gyroscope will benefit from the involvement of an end user, who will be able to provide information on the operating conditions; the performance of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Elucidating in-situ small molecule-RNA interactions by proximal reverse transcription-based sequencing'.

assistant: **Concept**

RNA is vital for cellular processes that include transcription, translation, and gene expression, making it an attractive drug target. However, deciphering the selective interaction between small molecules and RNA remains challenging due to RNA's dynamic structure and limited chemical functionality. Although FDA-approved drugs like Evrysdi have demonstrated the therapeutic potential of RNA binding small molecules, precise and reliable methods for targeting the interactions remain underdeveloped. This project aims to develop a Small Molecule-Assisted RNA Targeting and Reverse Transcription (SMART-RT) method to address this important challenge. The primary objective of SMART-RT is to create an in-situ interaction map of small molecules that interact with RNA or RNA-associated proteins (RBPs) in live cells. This innovative method will use RNA/RBP-binding small molecules to induce proximal reverse transcription (RT), enabling precise and sensitive mapping of RNA sequences and their interactions in their native cellular environment through downstream sequencing. By overcoming the limitations of current methods, SMART-RT will offer a detailed map of RNA/RBP interactions with small molecules, providing new insights and opportunities for the targeting of RNA biology and facilitating the discovery of novel therapeutics. This multidisciplinary project combines chemical biology, molecular biology, and medicinal chemistry to map RNA/RBP-small molecule interactions, using cutting-edge biotechnology for scientific exploration. It leverages my expertise in biochemistry and medicinal chemistry, providing extensive RNA technology training and fostering interdisciplinary collaborations. Aligned with MSCA’s goals of promoting innovation and knowledge transfer, the project will advance sci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Alternative Bearers for Rail' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

AB4Rail aims to identify and select alternative communication bearers (ABs) and selection of proper communication protocols for the Adaptable Communication System (ACS) of the Shift2Rail technical demonstrator TD2.1.  The project will review the state-of-the-art technologies assessing their suitability for the ACS in terms of expected performance, economic sustainability, and status of maturity. A wide spectrum of potential technologies have been identified including existing optical technologies for visible light communications (VLC), powerline communications (PLC) and short/long range technologies for the Internet of Things (IoT). Yet, breakthrough technologies under development and available in the next 3-5 years will be evaluated such as High-Altitude Platforms (HAPS) and high throughput Low Earth Orbit Satellites (LEO). The selected ABs will be tested in the lab (TRL 4) and on field (TRL 5) using the laboratories and on-field test bed of Radiolabs. A liaison with technology providers will be established leveraging on the network of Radiolabs, being the first in Europe having introduced, in 2015, a multi-bearer telecom architecture with public and satellite operators for ERTMS. The selection criteria for application/transport communication protocols will be assessed by theoretical results and simulations using an ad hoc software platform for network emulation/simulation at IP level to be developed in AB4Rail. Furthermore, AB4Rail is synergic with other projects funded by ESA, Shift2Rail, and Italian Ministry of Economic Development addressing multi-bearer telecom solutions for the ERTMS evolution. Special effort is allocated to the dissemination activities with the goal to involve the rail, telecom, satellite stake-holders and the standardization bodies. The project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sustainable options for people, catchment and aquatic resources' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

SPEAR aims to develop and test an integrated framework for interpreting coastal zone structure and dynamics, in areas where communities primarily depend on marine resources. This framework accounts for watershed interactions, ecological structure and human activities. Our interdisciplinary approach combines natural and social sciences, and addresses the complex scaling issues inherent in integrated management. Two contrasting systems in China will be studied: Sanggou Bay, part of a rural watershed, and Huan gdun Bay, located in an industrialized area south of Shanghai. In both systems, large-scale cultivation of seaweeds, shellfish and finfish are of paramount importance for community income and livelihood. Research and development will use existing local and regional datasets, ongoing Chinese field programs, archived and contemporary satellite imagery, with limited additional field and experimental measures. Complementary workpackages will establish the interactions between catchment use and coastal zone. Wor k will focus on fluxes of nutrients, organic matter and sediments, including exchanges at the seaward boundary and the role of ecological processes. Component models will describe the interactions both between cultivated species and with their environments , taking into account different levels of human interaction (e.g. resource exploitation, basin water management practices, and sewage discharge). Integrated modelling will permit the dynamic coupling of economic drivers responsible for social issues (over-exploitation, usage conflicts) with our ecological models, resolving inter-relations with the natural system. This will allow realistic testing of 3 contrasting management scenarios. Particular emphasis will be placed on how integrated multi-species aquacu ltur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hybrid CMOS/Magnetic components and systems for energy efficient, non-volatile, reprogrammable integrated electronics' (HYMAGINE).

assistant: **Concept**

Spinelectronics merges magnetism and electronics (Nobel Prize 2007). Besides its fundamental interest, it has found applications in hard disk drives (1998) and in non-volatile standalone memories (MRAM, on market since 2006). MRAMs integrate CMOS components with magnetic tunnel junctions (MTJ). The PI and his team are convinced that besides MRAMs, this hybrid CMOS/MTJ technology can yield a totally new approach in the way electronic devices are designed. Most CMOS devices such as microprocessors are based on Von Neumann architecture in which logic and memories are separate components. The unique set of characteristics combined within MTJs: cyclability, switching speed, scalability, makes it possible to conceive novel electronic systems in which logic and memory are intimately combined in non-volatile logic components (non-volatile CPU). Such systems would have outstanding advantages in terms of energy savings, logic-memory communication speed, ultrafast reprogrammability, compactness, design simplicity. The objective of this project is to lay the fundation of this novel approach, which requires addressing both fundamental and more applied issues. The basic issues concern the improvement and reliability of spintronic materials, mastering the speed and coherence of magnetization switching, developing tools for the quantitative interpretation of MTJ properties and for designing hybrid CMOS/MTJ devices. The applied goals are the conception, building and testing of a few illustrative devices demonstrating the outstanding advantages of this technology. A further one is to establish an internationally recognized roadmap for this non-volatile logic. If successful, its impact on European microelectronics and magnetism industry could be huge.