RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Counterfeit Pharmaceuticals Interception using RadiofrequencyMethods in Realtime' in the context of a Seventh Framework call.

assistant: **Objectives**

The CONPHIRMER consortium has come together to put into the hands of customs officers and other agents of law enforcement a portable and easy-to-use sensor for telling genuine medicines from fakes without having to remove the medicines from their packaging.  With this device agencies charged with tackling the growing menace of the trafficking in counterfeit medicines will be able to screen packaged pharmaceuticals at EU borders and airports quickly and accurately using a non-invasive and non-destructive technology that uses only harmless radio waves.The proposal is for a three-year programme leading to the trialing of a prototype, portable, handheld scanner, that will draw on the expertise of seven organisations in five states, including two recent additions to the EU family, Poland and Slovenia.  The technology employed will be based on quadrupole resonance (QR), a radiofrequency (RF) spectroscopic technique that has already been developed and deployed for the detection of concealed explosives.   The completed prototype will not require operators to have special chemical or technical knowledge to deploy it, allowing training in its use to be completed quickly; and it will utilise only easy to source RF and electrical parts, unlike alternative technologies such as Raman, infra-red or terahertz spectroscopic methods.  It will also offer a clear advantage over these other technologies in that RF can penetrate even multiple layers of packaging material, allowing for scans to be carried out without the need to remove pharmaceutical products from their packaging.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'First-in-class anti-PVR mAb NTX1088 - a novel oncology drug that unlocks the power of human immune system and revolutionizes cancer care' in the context of a Horizon Europe call.

assistant: **Objectives**

Nectin Therapeutics (NectinTx) is a venture-backed company with a top-notch team focused on innovative therapeutic options for cancer patients. To address the limitations of available therapies, the company has developed a diverse pipeline of antibodies that overcome immune inhibitory pathways deployed by the tumours. NTX1088 is a monoclonal antibody that binds human poliovirus receptor (PVR) and activates patients immune system to fight cancer through a triple mechanism of action never demonstrated before. A comprehensive preclinical dataset was generated to show the robust antitumor activity of NTX1088 in vitro and in vivo. Following IND approval and strong backing from key opinion leaders, Phase I clinical trial has commenced, aimed to enrol patients with solid tumours. The project will accelerate the clinical development of NTX1088 towards a novel therapy on the 80 billion immune-oncology drug market, resulting in better outcomes for patients and reduced societal and economic burden associated with cancer.


**Keywords:** oncology, immunology, drugs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mechanism and lnhibition of pantothenate synthase' (PAN).

assistant: **Innovation**

Pantothenate is vitamin B5, an essential dietary vitamin for humans and animals. The biosyntheticpathway leading to pantothenate has been elucidated, and the enzymes and their correspondinggenes isolated from E. coli. Since pantothenate is made by microorg anisms, plants and fungi, theenzymes which form pantothenate are potentially excellent targets for the design of antimicrobial 01herbicida! agents. This project centers on the enzyme pantothenate synthase, which catalyses the finalstep in the formation of pantothenate. Pantothenate synthase is readily available throughoverexpression of the cloned gene. The recently determined crystal structure of this enzyme will beused as a guide for both parts of this project:(i) detailed studies of the mechanism of actio nSite-directed mutagenesis will be used to probe the mechanistic role of key residues identified fromthe crystal structur, and to form stable enzyme-substrate complexes for structural studies. Thesubstrate specificity of pantothenate synthase will be explo red and attempts made to alter thesubstrate specificity by mutagenesis.(ii) design of enzyme inhibitors.Novel strategies will be used for rational inhibitor design, including Click chemistry andenzyme-templated dynamic combinatorial chemistry (DCC). Studie s using Click chemistry will initiallyuse a range of azides and alkynes based on the pantoate and adenosine, reacting via templating inthe presence of the enzyme, and so favouring products which bind the enzyme most tightly. Enzyme-templated DCC will invol ve the reversible reactions of pools of molecular fragments using excessenzyme to template the formation of products which bind tightly to the enzyme and so are potentialinhibitors. Fragments for both Click and DCC studies will be chosen using state-of-the -a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'How active black holes shape the Universe: beyond Hubble'.

assistant: **Innovation**

Super-massive black holes in the centers of galaxies have active phases during which they are believed to expel large amounts of gas, quench star formation and shape the evolution of the entire galaxy. Multi-wavelength searches for this destructive `feedback' force are ongoing, with the goal of answering two key questions: is black-hole feedback devastating and common enough to play a key role in the evolution of the Universe? And what is the physical mechanism behind this force of evolution?Driven by scientific and technological developments, the search is narrowing in on the crucial role of the cold gas, which is the raw ingredient for star formation. This Marie Curie Intra-European Fellowship project aims to complement the fellow's expertise in this research area at radio wavelengths with the world-leading expertise of the host institute in optical and infrared ""3D"" (integral-field) spectroscopy. The scientific objective is to use novel techniques on high quality data obtained with Europe's largest telescopes to quantify the effect that black-hole feedback has on cold gas in galaxies, and study how this influences galaxy evolution throughout the Universe.The coming years offer a crucial window to obtain the technical training required to fully exploit the `next generation' of world-class telescope facilities, with a leading role for Hubble's successor, the James Web Space Telescope (and on longer time-scales the European Extremely Large Telescope). The main career-development goal of this Marie Curie project is to position the fellow at the forefront of multi-wavelength optical, infrared and millimeter research on the role of active black holes in galaxy evolution during this exciting new era in observational astronomy. The involvement of the host's extra-galactic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'SafeConsumE: Safer food through changed consumer behavior: Effective tools and products, communication strategies, education and a food safety policy reducing health burden from foodborne illnesses'.

assistant: **Concept**

Food safety violations at the consumer stage are common and nearly 40% of food-borne outbreaks are occurring in the domestic setting. The overall goal of SafeConsumE is to provide effective, science-based and sustainable strategies for food authorities, market actors and the research community to help consumers mitigate risk, thus reducing the health burden from food-borne illness in Europe. SafeconsumE will suggest, develop and evaluate:  1) Tools, technologies and products (e.g. sensors, apps, hygiene concepts, kitchen utensils) that stimulate safe practices;2) Communication strategies that effectively stimulate adoption and market uptake of safer practices and tools/technologies; 3) Education programs increasing skills and knowledge aiding teenagers to handle food safely;4) Dynamic, sustainable and inclusive policy models that stimulates and support national and EU level initiatives.To achieve high implementation and innovation power, scientists will work together with consumers, authorities and different market actors under a new trans-disciplinary and multi-actor approach based on Theories of Practices combined with Design-driven innovation. Covering the five most important hazards causing food borne disease, consumer behavior across Europe will be described using a risk-based methodology and utilizing the strengths of high-throughput surveys together with in-depth qualitative methodology. New strategies will be developed taking into account their impact on risk reduction, documented consumer barriers for change and sustainability. SafeConsumE will support transformation towards a more healthy population and cost-efficacy by reduced foodborne illness, and a more sustainable community by less food-waste and environmentally friendly solutions.


**Keywords:** pathoge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Filling transitions for fluids at structured substrates and related phenomena.'.

assistant: **Innovation**

The purpose of this proposal is to further investigate the theory of interfacial phase transitions on structured substrates. From this study we hope to develop a more complete picture of the role that surface geometry plays in determining fluid adsorption and its interplay with interfacial fluctuation effects. We are interested in the phenomenology that arises at the micrometer scale, where fluctuations can be important. At this scale, effective Hamiltonian models are currently the only tools that allow us to study fluctuating interfaces. We will consider mainly the filling phenomenology in simple geometries like a wedge or a conic groove, and interfacial pinning atman apex or conic tip. The main objectives of our project are the following:a) To find the origin and explore the consequences of 2D wedge and 3D conic covariance, where by covariance we mean a hidden connection found between filling and wetting phenomena in planarsubstrates.b) To study the apex covariance, that recently has shown a new class covariance, different from the one exhibited by the wedge fillingsc) To study the nature of 3D wedge filling transition, that present strong fluctuation effects, and the role that the 2D wedge covariance can play into itsd) To investigate new interfacial phenomenology, like adsorption in a parabolic wedge, unbending transitions in striped heterogeneous arrays and adsorption of complex fluids in linear wedges, and the consequences of the results obtained in the previous items on them. These objectives will be met in the framework of equilibrium statistical mechanics, and the techniques that will bemused for this project will be analytical (including transfer matrix methods and renormalization group schemes), numerical minimization of free energy functional and Monte Car
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From Forest to Farmland and Meadow to Metropolis: What Role for Humans in Explaining the Enigma of Holocene CO2 and Methane Concentrations?' (COEVOLVE), addressing dissemination and exploitation.

assistant: **Impact**

The Holocene record of atmospheric CO2 and methane concentrations is an enigma. Concentrations of both gases increased from the beginning of the epoch 11,700 years ago to about 10,000 BP, then declined for several thousand years, but by 6000 BP, concentrations of both gases were steadily increasing again. This mid-late Holocene rise in greenhouse gases is unusual; similar patterns are not observed during previous interglacials. While various mechanisms have been proposed to explain these changes in Holocene CO2 and methane, there is one undisputed feature of this epoch that we know is different from the rest of Earth history: the existence of behaviorally modern humans. How humanity could have influenced the Holocene increase in CO2 and methane concentrations is the subject of the COEVOLVE project.In an interdisciplinary study that combines the social and natural sciences, we will reconstruct anthropogenic CO2 and methane emissions over the Holocene using a state-of-the-art model of terrestrial biogeochemistry and earth surface processes. The novelty of our approach is to develop a geodatabase of anthropogenic activities derived from historical and archaeological observations to drive our model, and to evaluate our simulations against a new, comprehensive global reconstruction of past land cover. COEVOLVE is organized around three activities: 1) synthesis of observations of past land cover change from paleoecological archives, 2) development of a spatial database of the spread of technology, industry, culture, and trade that influenced global land use and resource consumption patterns and 3) informed by parts 1 and 2, modeling of terrestrial biogeochemical cycles and land surface processes including deforestation, soil erosion, and fire. With a new perspective on preind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Functional surface treatments using ultra-short pulse laser system FemtoSurf'.

assistant: **Innovation**

The tremendous success of lasers in industry resulted in massive demand for photonics-based solutions. At the moment lasers are inseparable part of fields like communications, medicine, science and heavy industry. This is due to outstanding versatility of light, as it can be used as means for both measurement and direct processing. One of the newest developments in the field is advent of ultra-fast femtosecond (fs) lasers. Alongside all the standard laser properties, these lasers add capability to control temporal and thermal characteristics of light-matter interaction as well as eliminate any material related restrictions due ultra-high light intensities achievable. For these reasons fs lasers are predicated to play pivotal role in 4th industrial revolution with ultrafast laser marked projected to grow up to 7.1 billion dollars by 2021. Direct surface treatment is one of the key areas where fs lasers proved highly promising. Specific light-matter interaction regimes enabled by fs pulses allow to create surface patterns in scales ranging from nanoripples to millimetre-sized grooves. Such surface features could be made into either repelling or adhering. As it is direct process applicable for any kind of surface metal patterning is especially interesting, as it could find use if fields like medicine, aerospace, maritime and tool manufacturing, replacing various coatings, lubricants or enabling entirely new properties. The main objective of FemtoSurf is to exploit the newest advances in laser development for creation of industrial-grade 2-3 kW-level fs laser that would be integrated in propose-built optical chain enabling multi-beam processing (up to 100 simultaneous beams) with individually controlled spatial distributions in each laser spot, integrated into a fully autom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Europe’s Lost Frontiers: exploring climate change, settlement and colonisation of the submerged landscapes of the North Sea basin using ancient DNA, seismic mapping and complex systems modelling' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The only lands on Earth that have not been explored in any depth by science are those that have been lost to the oceans. Global warming at the end of the last Ice Age led to the inundation of vast landscapes that had once been home to thousands of people. These lost lands hold a unique and largely unexplored record of settlement and colonisation linked to climate change over millennia. Amongst the most significant is Doggerland. Occupying much of the North Sea basin between continental Europe and Britain it would have been a heartland of human occupation and central to the process of re-settlement and colonisation of north Western Europe during the Mesolithic and the Neolithic. Within this submerged landscape lies fragmentary yet valuable evidence for the lifestyles of its inhabitants including the changes resulting from both the encroaching sea and the introduction of Neolithic technologies.This inundated landscape cannot be explored conventionally, however pioneering work by the applicant’s research group has led to the rediscovery of Doggerland through the creation of the first detailed topographic maps relating to human occupation in the Early Holocene. Within this project world-leading innovators in the fields of archaeo-geophysics, molecular biology and computer simulation will develop a ground-breaking new paradigm for the study of past environments, ecological change and the transition between hunter gathering societies and farming in north west Europe. It will:1) use the latest seismic reflectance data available to generate topographical maps of the whole of early Holocene Doggerland that are as accurate and complete as possible.2) reconstruct and simulate the palaeo-environments of Doggerland using ancient DNA extracted directly from sediment cores.3) explore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Artificial Wet Neuronal Networks from\nCompartmentalised Excitable Chemical Media' (NEUNEU), addressing dissemination and exploitation.

assistant: **Impact**

This research programme will be concerned with the development ofmass-producible chemical information processing components and theirinterconnection into functional architectures. The project has threecomplementary objectives. The first is to engineer lipid-coated waterdroplets, inspired by biological cells, containing an excitable chemicalmedium and to connect the droplets into networks in which they cancommunicate through chemical signals. The second objective is to designarchitectures based on the droplets and to demonstrate purposefulinformation processing in droplet architectures. The third objective is toexplore and establish the potential and the limitations of dropletarchitectures, both from a theoretical perspective and with laboratoryprototypes. We expect that this collaboration among computer-scientists,bio-physicists, chemical-physicists, biochemists, chemical-biologists, andelectrical engineers will develop a flexible and efficient substrate formolecular information technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantum Physics with Attosecond Pulses' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project lies at the crossing of attosecond science, photoionization of atoms and molecules and quantum optics. Progress in the performances of the attosecond sources, in particular regarding repetition rate, now enables us to perform photoionization studies of atoms and molecules using advanced coincidence/three dimensional momentum techniques. Adding an additional dimension, the phase, which is accessible by attosecond interferometric techniques, we will able to follow in time the quantum properties of the studied processes.The aim of the present application is to perform quantum optics experiments, not with photons as in conventional quantum optics, but with electron wave-packets created by absorption of attosecond light pulses.  Our objectives are -to characterize and study in the time domain the quantum coherence of attosecond electron wavepackets, -to control quantum interferences of electron wavepackets using a small number of attosecond pulses and -to create and follow in time entangled two-electron attosecond wavepackets.The experiments will use advanced laser systems, attosecond sources and electron detectors. A unique 200-kHz repetition rate laser system based on optical parametric chirped pulse amplification technology, combined with an efficient attosecond source and a three-dimensional momentum electron detector will open the door to attosecond experiments where the kinematics of the light-matter interaction can be recorded. The success in achieving the above objectives will not only lead to a major leap forward in attosecond science and atomic and molecular physics in general; it might shed new lights in fundamental quantum physics, given the originality of the studied systems, attosecond electron wave packets and the versatility of the tools, providi