RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Basis and development of molecular approaches to nematode resistance' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Nematodes are one of the most important groups of plant parasites and cause significant crop losses world-wide. The objectives of the proposed programme are to gain insight into the molecular mechanisms underlying the pathogenesis and to develop gene constructs that will protect crop plants against these pests. The programme deliverables will be a set of genes tested for their anti-nematode effect, suitable promoters to drive genes active against nematodes and a fuller understanding of plant-nematode interactions. Sedentary nematodes induce re-differentiation of root cells into a permanent nematode feeding site (NFS) that nourishes the developing nematode. Recent data strongly suggest that the glycoproteins secrete from the nematodes sub ventral glands initiate this process but little information is available about how these proteins govern the development of the feeding site. Even more enigmatic is the actual signal transductio pathway from the nematode signal to activation of the plant genes that are involved in induction of the nematode feeding sites. Possibly, one or more nematode secretory proteins interact with plant regulatory proteins o directly with the DNA and in this way initiate a cascade of altered gen expression. The secretory proteins will be characterised using antibodies and their function in plant pathogenesis will be determined. Several gene have recently been shown to be induced in the NFS but their role i induction or maintenance of the feeding site remains to be proven. Nematode responsive promoters will be cloned and a molecular dissection will identify specific regulatory elements that are responsible for expression in the nematode feeding site. These elements will then be use to construct more specific promoters. The role of the genes that are h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Solution for cost-effective integration of renewable intermittent generation by demonstrating the feasibility of flexible large-scale energy storage with innovative market and grid control approach' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective of eStorage is to develop cost-effective solutions for the widespread deployment of flexible, reliable, GWh-scale storage across EU, and to enhance grid management systems to allow the integration of large share of renewable.The key issue we plan to address is the need for power regulation during low demand periods, when only inflexible baseload generation and intermittent renewable generation are operating. In contrast to conventional generation, a storage plant able to regulate its consumption could help to avoid curtailing wind.Conventional Pumped Storage Hydro Plants (PSP) can only regulate their power in generation mode; variable speed technology for PSP can bring the additional flexibility in pumping mode as well. Developing technically and economically feasible solutions in eStorage will allow upgrading a significant part of European PSP capacity to variable speed, providing up to 10 GW of additional regulation capability with no environmental impact and little administrative burden, all at a much lower cost than developing new plants.We will also develop and demonstrate solutions for coupling the dispatch of storage plants with renewable generation using advances Energy Management Systems. This will enable storage plants to maximise their value in the balancing markets.. From simulation studies, demonstration results and storage potential analysis we will evaluate the system-level benefits of storage and identify development barriers in order to draw recommendations for efficient market and regulatory framework to maximise the impact of project outcomes.eStorage gathers major stakeholders from the entire value chain across EU (Elia – TSO, EDF – Generation Company, Imperial College – Academic Institution, Kema – Engineering Consultancy and Alstom –
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Preparation of fine particles by spray pyrolysis' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content Aerosol processes for the generation of nano-structures powders and films have the potential to provide numerous new industrial applications. Such materials show improved or even new properties compared to the ones of micro- or macro-structured materials. The scientific and technology issue of nano-structured materials are on the verge of becoming a wide research and development field of high actuality and relevance to the technical sciences and beyond. Far-reaching applications can be anticipated in life sciences, materials science, in high-tech engineering, and in clean and durable industrial production processes. One route which is of great interest is spray pyrolysis. In collaboration with industry the following objectives have been defined: (i) to show that spray pyrolysis is capable of producing powders over a wide range of chemical composition, particle size and density; (ii) to establish the fundamental mechanisms of particle formation; (iii) to develop a theoretical model for spray pyrolysis and (iv) to develop criteria for predicting the surface area and grain size of particles when the reactor temperature and residence time are varied. Commercial organisations identified the following types of powder as being of interest to them: (i) ceramic, (ii) metal ruthenate, and (iii) Bi-Sr-Ca-Cu-O. Training content (objective, benefit and expected impact) The main training objective is to gain a deeper insight into the physical-chemical nature of the complex processes in aerosol production of nanophase materials. By its nature this research is interdisciplinary and I will gain valuable training not only in aerosol science but also aspects of material science. Essex is one of two institutions in the UK undertaking such research. There is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'HOMER - Development of Home Rehabilitation system' (Homer) under Horizon 2020.

assistant: **Objectives**

Kinestica, an R&D oriented SME founded by a team of experts in biomedical and rehabilitation engineering with 50 years of combined experience, has developed disruptive TRL7 solution that will revolutionize the field of post stroke rehabilitation and home care. Stroke affects 15 million people around the world annually. More than 75% of stroke survivors are left without proper rehabilitation in the most crucial stages of the recovery. In EU alone, cost of stroke is estimated at €38 billion. HOMER project (HOME Rehabilitation) will be first-ever open-access rehabilitation system to integrate patented motion capture technology with virtual reality and open-source ICT platform to provide accessible and cost-effective solution. HOMER will extend limited rehabilitation patients normally receive and thus drastically improve rehabilitation therapy outcomes for large number of stroke patients. It will be 10 times more affordable than current state-of-the-art systems available on the market. HOMER addresses challenges laid down in eHealth Action Plan 2012-2020 and helps to overcome current gaps in exploitation of promising research results in ICT for Health, Well-being and Ageing well. Commercialization of HOMER will include several channels. For initial launch we will collaborate with existing partners and distributors of our clinical rehabilitation solutions. We will engage rehabilitation institutions already using our clinical devices to help promote Homer. Later direct sales channels through internet, company branches and franchises will be included. The strategy will enable us to reach large populations of stroke patients in need for effective and affordable rehabilitation solution. HOMER promotes excellent science and encourages innovation, thus contributes to multiple EU a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'How pathological mutations and drugs alter the intracellular movements of the cardiac sodium channel (Nav1.5).'.

assistant: **Objectives**

The sodium voltage-gated ion channel Nav1.5 is a key player in shaping the cardiac action potential. Hundreds of pathological mutations that lead to the dysfunction of Nav1.5 are linked to severe pathologies, such as life-threatening arrythmias. The function of these channels is based on precise voltage-dependent molecular motions that result in the opening and closing of their sodium-conducting pore. Despite very recent advances in determining their atomic structure, knowledge of the dynamics of these conformational changes is still lacking. Similarly, it is unknown how pathological mutations, clinically used drugs or post-translational mutations affect these changes. In this project, I therefore propose to – for the first time - decipher the dynamic motions of the Nav1.5 intracellular domains by combining the measurement of the functional state of Nav1.5 through electrophysiology with fluorescent sensor recordings of the motions via voltage-clamp fluorometry. The challenge of establishing a fluorescent sensor on the intracellular domains of Nav1.5 will be overcome by the generation of semi-synthetic Nav1.5 that are engineered to contain a fluorescent dye via tandem protein trans-splicing. The probed motions will be then interrogated in the presence and absence of pathological mutations, drugs and post-translational modifications, such as phosphorylation. This will yield unprecedented insight into their mechanisms of action and will help to propose new ways of targeting the regulation of Nav1.5. This novel approach will therefore have direct implications for the future treatments of patients with cardiac arrhythmias. This innovative project, in an international environment, at the interface of biophysics, fluorescence, pharmacology and peptide synthesis, will also help
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Aircraft Reliability Through Intelligent Materials Application', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The objective of the proposed research is to achieve a leap improvement in aircraft reliability through the application of smart materials. There exists an acute need to develop the capability to monitor aircraft structural health in real-time, in a reliable manner. Real-time structural health monitoring will not only improve the overall safety but will also made it possible to replace Corrective or Preventive maintenance modes with much more efficient Predictive or Proactive maintenance procedures- thus reducing the associated cost. Similarly, vibrations and noise levels are still to high in certain aircraft. Systems based on smart materials defined as solid state actuators activated by external fields, e.g., electric or magnetic, can address all these factors. Smart materials have already reached a sufficient level of maturity to benefit from their unique characteristics not only in laboratory but also in an industrial environment. No moving parts, the ease of integration with metallic and composite structures and the capability to provide distributed actuation are among their most important characteristics. This project will take advantage on an extensive body of knowledge accumulated during nearly two decades of development of smart materials and their applications. The proposed project will give a final push to produce realistic industrial solutions for real- time structural health monitoring and aircraft vibrations reduction. The most promising methods will be tested on large-scale specimens, such as a portion of a commuter aircraft fuselage. Project goals will be achieved by a network consisting of several production companies, research institutes and universities. The know-how developed as a part of this project is ideal to stimulate creation and development of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effect of neuropeptides on selective neuronal differentiation of mouseembryonic stem cells' (PEPSTEM) targeting Seventh Framework.

assistant: **Abstract**

The capacity of embryonic stem cells (ES cells) to differentiate into neuronal cells represents a potential source for neuronal replacement and a model for studying factors controlling early stages of neuronal differentiation. Various molecules have been used to induce such differentiation but so far neuropeptides acting via G-protein coupled receptors have not yet been profoundly investigated. Since undifferentiated ES-cells express numerous G-coupled receptors which expression is increasing with time in culture, it suggest a prominent role of these receptors in the maintenance and development of ES cells. RT-PCR analyses of Ghrelin is proven to have a prominent effect on the growth and proliferation of the neural progenitor cells in the dorsal motor nucleus of the vagus (DMNV), but its effect on ES cells has not yet been investigated. MC4 receptor, which binds both alpha-MSH and AgRP is expressed by ES-cells but wheter it has a function on neuronal differentiation is unknown. Y1 and Y5 receptors of NPY have proven to have a significant role in maintaining the pluripotency of ES cells. These original data demonstrate that functional G-protein coupled receptors have a role on differentiation into a neuronal phenotype. It opens an exciting new field for neuropeptide regulation of tissue ontogenesis. Using a three-dimensional „minibrain” could reveal potential selective differentiation in the forming tissue. Since these neuropeptides often regulates each other’s expression in the adult brain, it would be interesting to see whether these regulation networks can form in vitro in a differentiating cell-culture. This would open new ways of studying the effect of neuropeptides on neural differentiation and synaptic network formation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Handcrafted Coalitions: Tantear beyond Borders through Digital Mapping' (HANDigiCRAFT), addressing dissemination and exploitation.

assistant: **Impact**

When we hear about migration and asylum, we usually think of struggles at border crossings, extensive bureaucratic procedures, and the precarious situation of migrants. We rarely think of the objects handcrafted by people on the move, the knowledge these objects entail, what these objects make possible, and the stories these objects tell about the journeys of people on the move. HANDigiCRAFT takes an innovative step by paying attention to objects handcrafted by people on the move and the relations knitted around them, both of which remain unseen by conventional concepts and methods.In asking what the social life of objects handcrafted by people on the move is, HANDigiCRAFT reframes handcrafting as a knowledge practice that mediates social relations beyond borders. It theorizes such relations by developing the concept of handcrafted coalitions; temporary or permanent everyday alliances and achievements between actors engaging with objects handcrafted by people on the move. HANDigiCRAFT thus creates a new method: Tantear handcrafted coalitions. Tantear can be loosely translated from Spanish as 'collectively knowing through the hands'. I draw on this notion to combine it with ethnographic methods and digital mapping. Hence, upcycled clocks in Greece, crafted jewelry in Spain, and paper sculptures in Colombia will be made digitally legible to map their trajectories and learn from their journeys. An interactive multimodal platform will render accessible the thus far unknown stories around handicrafts provided by those engaging with them worldwide.The contributions of HANDigiCRAFT include making graspable (textually, visually, and interactively) the meanings that handicrafts entail for their makers and users. Besides advancing discussions of the mobility of humans and non-hum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Parameterisation of the aerosol activation process in a climate model: Evaluations and improvements with observations and sensitivity studies' (AEROSOL-CLOUD-IN-GCM) targeting Sixth Framework.

assistant: **Abstract**

Aerosol particles modify the radiative properties and the lifetime of clouds in the atmosphere, and possibly result in severe changes in the global climate that influence human lives (aerosol indirect effect). To better understand the effect of aerosols on clouds and the climate, representations of the activation process of aerosols to form cloud droplets is a crucial factor. Sensitivity studies on different parameterizations of the activation process will be conducted in a climate model to investigate their performances and optimize the representation of this process. Two important mechanisms will be incorporated in the parameterization of the activation process in the climate model. One is the kinetic effect. Including this effect, the activation process w ill be parameterized in the climate model more realistically and the model can predict the cloud droplet number concentration more accurately. The second mechanism is the dispersion effect, in which the influence of an increasing number of aerosols on the cloud droplet size distribution will be included and its impact on the aerosol indirect effect will be investigated. Both modifications on the parameterization of the activation process will be tested against in-situ observational data in the proposed research project. The goal is to simulate the aerosol-cloud interaction more realistically and efficiently in the global climate model, to reduce the uncertainty of model estimates of the aerosol indirect effect and to improve our understanding of future climate change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Personalized Cancer Immunotherapy through DNA-EP vaccines', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

TK-NEO is a DNA-based Neoantigen Cancer Vaccine (NCV), for use as therapeutic vaccination in patients with locally advanced or metastatic solid tumours.  NCVs are a new form of precision medicine and are a perfect clinical approach for highly heterogeneous tumors in patients with metastatic disease. Takis has developed and patented a unique method for production of patient-specific NCVs based on a 6-week process, from sequencing the specific tumour DNA, synthesis of the right DNA sequence for the specific tumour, delivery through a specific Electroporation (EP) technology used under exclusive license. The solution was proven at pre-clinical stage to reduce to zero a human lung cancer in humanized mice in 60 days and to increase the efficacy several fold with respect to alternative RNA and DNA based NCVs in protecting relapse and boosting immune responses as required for the maintenance of long-term anti-tumor immunity.The strategy to reach the market for TK-NEO is to license the IP of TK-NEO to a large pharma company, after completion of clinical validation trials to demonstrate the applicability and safety of the approach: phase I clinical trials in melanoma are targeted during SME Instrument project, while implementation of a GMP manufacturing to carry out phase II clinical trials and the implementation of the trials will require additional 5M investment. The Total Available Market is constituted by melanoma patients who underwent surgery and first chemotherapeutic treatment, who are estimated in the order of 30.000 patients per year combining EU and US. The objectives of the feasibility study are: 1) to validate the feasibility and the authorization process for the release tests, 2) to confirm investment, cost and pricing for TK-NEO, 3) to define a MoU with VC or wit