RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Effects of UVB in humans:photoproducts and their transformation to P53 mutations as risk indicators.' in the context of a Fourth Framework call.

assistant: **Objectives**

The objective of the project is to measure different kinds of UVB-induced photoproducts and their repair in human skin. In time-course experiments the appearance of p53 mutations will be followed in the sample from which photoproduct levels are known. By comparing individuals with a risk of skin cancer the role of different types of photoproducts and their repair rates will be determined.Skin samples will be obtained either from healthy individuals or from patients undergoing skin biopsies for  naevi, skin cancer or other skin diseases. These will be used for studies of adducts and mutations in the summer  and winter time with consideration of sun exposure in the skin area. Biopsies distal from the area of lesion will  be used for analysis, to avoid the presence of malignant tissue in the samples.  Experimental irradiation of patients will be carried out on those suffering form psoriasis, atypical mole  syndrome (AMS) and early onset basal cell cancer. Subjects will be irradiated with UVB-source on the buttock  with a dose 2 x minimum erythema dose and sampled using a 3-5 mm punch biopsy at various intervals after  irradiation. The biopsies will be immediately frozen in liquid nitrogen. The exact times of biopsy will be  determined in preliminary experiments designed to follow the disappearance of the adducts and appearance of  p53 mutations.  UV-photoproducts will be analysed by a modified 32P-labelling technique, where DNA is digested to  trinucleotides containing photoproducts and nucleosides with DNase I, snake venom phosphodiesterase and  prostatic acid phosphatase. These enzymes are unable to cleave phosphodiester bonds between pydimidine  dimers, and additionally leave an unmodified nucleotide to the 5'-end of the trinucleotide. This is important  for good labell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cancerbiome: Characterization of the cancer-associated microbiome' (CANCERBIOME) targeting Seventh Framework.

assistant: **Abstract**

Deep environmental sequencing (metagenomics) will be used to characterize microbial communities associated with 3 different cancer types: cervical cancer, oral squamous cell carcinoma and colorectal cancer. For all 3 types, non-invasive molecular diagnostics and prognostics are feasible via utilization of vaginal, oral and faecal samples, respectively. The project consequently aims to identify microbial markers in these ¿readouts¿ that correlate with cancer presence or progression. Microbial markers can be individual species or specific community compositions, but also particular genes or pathways. The microbial communities will be sampled locally at tumor surfaces and in healthy control tissues. After DNA extraction and sequencing, a complex bioinformatics pipeline will be developed to characterise the microbiomes and to identify the cancer-specific functional and phylogenetic markers therein. For colorectal cancer, the project intends to go into more details in that it tries i) to establish a correlation of microbiota with cancer progression and it ii) explores differences between distinct cancer subtypes. For each of the 3 cancer types, at least two samples from 40 individuals will be sequenced (as well as controls) at a depth of at least 5Gb each using Illumina technology. This is expected to be sufficient for the identification of microbial markers and also allows superficial genotyping of the individuals at ca 2-3x coverage as a by-product (the samples will contain considerable amounts of human DNA). Further analyses will be designed to study the potential of certain microbial species or community compositions to enhance or even cause one or more of the 3 cancers. The discovery of such causations will open up research towards directed antimicrobial treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Effects of rewiring microexons (REMIX) on tissue-specific signaling networks'.

assistant: **Concept**

Signaling networks control a vast range of complex cellular behaviors. The wiring of these networks varies greatly from one cell type to another in the body, depending on the specific functions required of different tissues. However, the mechanisms controlling the tissue-specific wiring of signaling networks are poorly understood. Kinases play a major role in directing signal flow by interacting with and phosphorylating specific target proteins. Interestingly, recent studies on the tissue-specific alternative splicing of very small exons called microexons found an enrichment of these microexons in kinases. This raised the question of whether microexons might occur in regions of kinases mediating specific kinase-substrate interactions. Theoretically, such “rewiring microexons” could contribute to the differential regulation of signaling networks in different cellular contexts. Furthermore, their dysregulation could potentially lead to pathogenic signaling in diseases such as cancer.Accordingly, the proposed research will address the questions: What role do microexons play in regulating kinase substrate specificity and tissue-specific wiring of signaling networks, and what are their potential roles in cancer cell signaling? To answer these questions, I will (1) experimentally determine the substrate specificities of kinases with/without microexons, (2)demonstrate the ability of the candidate microexons to rewire cellular signaling networks, and (3) investigate the dysregulation of kinase microexons in cancer using bioinformatics. This multidisciplinary study will fill a gap in our understanding of the functional roles of microexons in regulating kinase substrate specificity, and help to unravel the mechanisms underlying the immense variation of signaling activities betwee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development and Performance Testing of CMC-Materials Based on C-Fibres for Application in UHTHE (B3)' in the context of a Fourth Framework call.

assistant: **Objectives**

This project is part of a project network with the aim to develop and test in a service plant new compact and cost effective Ultra High Temperature Heat Exchanger (UHTHE). The improvement of thermal efficiency of high temperature processes requires improved reliability and durability of the applied materials.New electrical generation plants based on the so called Externally-Fired-Combined-cycle, a typical high temperature andcorrosive stream based industrial process, offers the opportunity to increase the relative thermal efficiency up to 25% by improved high temperature combustion cycles. In this superior combustion cycle, the key component is the Ultra High Temperature Heat xchanger (UHTHE), based on CMC materials. Therefore, C/SiC materials are one of the most promising candidate materials. The aim of the proposal is the development of a low cost C/SiC material with a non catastrophic, pseudoplastic failure behaviour an a suitable thermal shock resistance. Furthermore, the material has to be oxidation resistant. Therefore, a further topic of the project is the development of compatible surface coatings for plates and tubes. The lack of information on reliability and durability requires a performance testing in respect to applications in UHTHE. The performance testing of the materials includes mechanical characterization at low and high temperatures, burst tests of tubes, micromechanical studies, NDT, thermal characterization, erosion and corrosion tests as well as combined corrosion/erosion and combustion tests. The input of the parallel running projects and the project management structure allow a good comparison of the development and its competitiveness to monolithic ceramics as well as high cost SiC/SiC materials. The aim of the development of low cost C/SiC mate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Silicon at the Atomic and Molecular scale' (SiAM).

assistant: **Innovation**

SiAM aims at exploiting in future ICT devices and circuits the atomic nature of dopants used throughout microelectronics. The key idea is to use the very sharp, deep and reproducible potential created by a dopant in a semiconductor host crystal. Despite its small size (on the scale of the Bohr radius), the donor state of a single dopant can be addressed with conventional lithography techniques, and is therefore perfectly suitable for realistic devices exploiting the quantum nature of single atoms.The project relies on:- The extremely mature silicon technology in which, however, no quantum mechanical or atomic properties are at play when dopant atoms are used.- The very atomic nature of these dopants.<br/>The consortium will investigate dopants:- At the device level, with the demonstration of atomic devices (single dopant) and molecular devices (coupled dopants).  A crucial effort towards integration of deterministic implantation in CMOS technology will be made.- In the theoretical understanding, for exploiting the specific features of dopant-based devices, especially time-dependent processes.- At the system level, with circuits exploiting the atomic characteristics of  dopant based devices.<br/>The consortium brings together three methods for fabricating single-atom transistors: top-down silicon fabrication, bottom-up growth of nanowires and Scanning Tunneling Microscope (STM)-assisted fabrication. This is a unique combination of expertises only available in Europe. In addition, metrology and theory experts will exploit time-dependent phenomena in atomic devices for applications such as electron pumps.Another opportunity is to address directly the spin of a single dopant and make use of its extremely long coherence time to make a single atom quantum bit, crucial for app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Integral homology of toric varieties'.

assistant: **Concept**

The filtration of a toric variety by equivariant skeletal leads to a spectral sequence converging to the variety's Borel-Moore homology. Its E^1term is the direct sum of exterior algebras associated to the cones contained in the fan defining the toric variety. For rational coefficients this spectral sequence degenerates on the E^2 level. I conjecture that this holds true also over the integers and that there is no composition problem, i. eo, that one can compute the integral Borel-Moore homology of a toric variety from an explicitly known complex. This conjecture is supported by numerous examples. If true, it would be the first method to effectively compute the integral homology of singular toric varieties. The project is related to various topics at the borderline between topology and geometry, in particular to the homology and cohomology of algebraic varieties and their Chow groups. For instance, my conjecture would imply that the canonical map from Chow groups to Borel- Moore homology is injective for all toric varieties. Equivariant cohomology and equivariant Chow groups give additional information and will therefore be considered as well. Here Koszul duality comes in as an important algebraic tool to translate between ordinary and equivariant objects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Photon Counting Spectral Computed Tomography' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Due to its speed, accuracy and availability Computed Tomography (CT) is a routine tool for imaging of cardiovascular disease, stroke, cancer and trauma injuries; every year over 100 million patients are examined using CT, making it one of the most common medical imaging procedures. Despite a significant development, current CT detectors are unable to obtain sufficient spectral information and have a limited spatial resolution. This leads to image artefacts and limited visualization of important details. Healthcare providers are thus forced to use more expensive and slower modalities like MRI and PET, translating in increased healthcare costs and risk since time to treatment is prolonged. Our solution is a novel photon counting spectrally resolved detector, developed and fully owned by the SME Prismatic Sensors. The technology offers a factor two higher spatial resolution, elimination of artefacts and increased dose-efficiency compared to state-of-the-art clinical CT scanners. Millions of people around the world would benefit from our technology through improved diagnostics and speed of care. In addition, radiation dose and the associated risk is dramatically reduced. The project will result in a fully tested and validated photon counting spectral CT detector ready for commercialization. The technology and the added clinical value will be validated and compared with state-of-the art in a clinical trial by radiologists at the Karolinska University Hospital. As an outcome, Prismatic Sensors expects the new patented detector technology to be the future choice for some or all the major global vendors. This will support Europe's position as a world-leader in medical innovation and healthcare technology, as well as improve hospital efficiency and save healthcare costs. Most im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FIRST MLOPS INTEGRATING REAL-TIME RISK MANAGEMENT, COMPLIANCE AND EXPLAINABILITY WHERE THE AI MODEL RUNS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Deeploy presents the world's first human-centric AI MLOps platform that integrates real-time risk management, explainability, and compliance directly within the infrastructure where models run. This ensures safe, reliable, ethical, transparent, and accountable AI deployments, instantly minimizing risk exposure and reducing the time needed to resolve incidents. Deeploy’s platform stands out by embedding these critical elements into the AI lifecycle, providing unparalleled oversight and control, which is essential in regulated industries. By leveraging advanced eXplainable AI (XAI) techniques, real-time monitoring, and bias mitigation tools, Deeploy offers a robust and user-friendly system that addresses the urgent need for ethical AI in heavily regulated industries such as finance, healthcare, and government. Our innovative approach meets regulatory requirements and builds stakeholders' trust by making AI decisions understandable and justifiable.We strive to ensure regulatory compliance with stringent laws such as GDPR and the EU AI Act, providing tools for continuous monitoring and documentation of AI models. Another critical objective is to mitigate biases in AI models, promoting fair and ethical outcomes across various applications. Our strategy includes scaling our solution across European markets, starting with the Netherlands and Germany, followed by other regions, ensuring widespread adoption and impact. This aligns perfectly with the goals of the EIC Accelerator's Human Centric Generative AI challenge, contributing substantially to the EU's digital transformation agenda. Through our platform, we aim to set new standards for responsible AI, driving positive change and fostering innovation across industries.


**Keywords:** Fintech,  Data protection and privacy,  W
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Value of Refugees: The Impact of Inter-Asian Tibetan Buddhist Patronage Networks' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project examines transnational patronage of the Tibetan diaspora and tracks its overlapping geopolitical and sociocultural impact at local, national, and international scales. In this project, I will first map transnational patronage, increasingly from Buddhist organizations sweeping across East and Southeast Asia, and second investigate its impact on the material, spiritual, and psychosocial landscape of the Tibetan diaspora in India. By combining anthropology, religious studies, and international relations, the project will generate new data on how the intersection of geopolitics and global Tibetan Buddhism shapes diasporic Tibetan identity and ethnic belonging in Indian settlements. In short, the project analyzes the recursive loop between transnational patronage and Tibetan identity formation within the Indian milieu it most directly impacts and against the backdrop of Chinese geopolitics it most clearly reflects. As such, it will be the first quadratic analysis of diasporic Tibetans grounded in ethnographic fieldwork. The imbrication of global Tibetan Buddhism, patronage networks, and refugee politics necessitates scholarship which analyzes value creation and attendant forms of soft power. Such research is a corrective to an anti-materialist “Othering” within Tibetan Studies which, paired with lay New Age Orientalism, distorts the ethnographic picture of contemporary Tibetans.


**Keywords:** diasporaic religion,  tribal studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart acellular scaffolds for bone repair' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The use of Acellular Technology to stimulate the body’s own repair processing is an emerging direction in regenerative medicine, which may tackle one of challenges in orthopedic treatment where how to treat bone loss or bone fracture due to osteoporosis is unsolved.The main objective of this project is to biofabricate new bioinspired scaffolds enabling off-shelf, scalable and stimulating multiple cellular actions including stem cell infiltration/adhesion; differentiation of osteoblast and endothethial cells for treatment of bone defects. The proposal will develop new multifaceted 3D composite scaffolds combined the advantages of electrospun nanofibers, porous foam and active chemicals conjugation enabling to provide biological, physical and mechanical properties for mesenchymal stem cells adhesion, migration, and differentiation and angiogenesis. The proposal will also develop an in vitro dynamic culture model mimicking bone development in vivo to evaluate the efficiency of scaffolds in order to reduce the use of animal models.The project proposes to bring an outstanding young researcher, Dr Lü, who was trained in the State Key Laboratory of Bioelectronics in Southeast University, the top 20 university in China, to undertake such multidisciplinary research project with host institution in Keele University, UK. Dr Lü has worked in biofabrcation field in past 5 years, and have established excellent track record in smart nanofiber fabrication and applications. The fellow’s experience and knowledge will be effectively transferred to host group and other European research groups through the delivering the targets of the project and disseminating of her previous research outcomes by seminar, joint publication and visiting other laboratories.  The fellowship will also aim to b