RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular mechanisms underlying plant miRNA action' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

MicroRNAs (miRNAs) are 20-22 nt non-coding RNAs that regulate gene expression post transcriptionally via base pairing to complementary target mRNAs. They have fundamental importance for development and stress adaptation in plants and animals. Although a molecular frame work for miRNA biogenesis, degradation and action has been established, many aspects of this important gene regulatory pathway remain unknown. This project explores four main points. First, we propose to use genetic approaches to identify factors required for translational repression by miRNAs in plants. This mode of action was until recently thought to occur only exceptionally in plants. My post doctoral work showed that it occurs in many miRNA-target interactions. The mechanism remains unknown, however, leaving open a fertile area of investigation. Second, we wish to test specific hypotheses regarding the in vivo role of miRNA mediated endonucleolysis of mRNA targets. Long believed to serve exclusively as a degradation mechanism, we propose to test whether this process could have important functions in biogenesis of long non-coding RNA derived from mRNAs.Third, my postdoctoral work has provided unique material to use molecular genetics to explore pathways responsible for miRNA degradation, an aspect of miRNA biology that only now is emerging as being of major importance. Finally, our unpublished results show that plant miRNAs and their associated effector protein Argonaute (AGO) are associated with membranes and that membrane association is crucial for function. This is in line with similar data recently obtained from different animal systems. We propose to use genetic, biochemical and cell biological approaches to clarify to which membrane compartment AGO and miRNAs are associated, how they are recruit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Physics of colloids,emulsions and foams' (1994-1998).

assistant: **Concept**

Research objectives and content Colloids, emulsions and foams are generic structures for many foods, detergent and personal products. V shall investigate specific links between the micro- and macro-scopic structures which influence dynamir and rheological properties and which in turn influence processing and user characteristics. We also seek to develop an applied focus for physics research on colloids and foams in Ireland, primer at TCD but also with other relevant research groups in Ireland Our overall aim being to enhance lir between these research groups and relevant industry thereby aiding exploitation of this research within t industrial sectors noted above. Traning content (objective, benefit and expected impact) The applicant will give 1) a series of seminars aimed at introducing graduate students and non-experts to the subject of colic within the context of the needs of the food industry. 2) a workshop concerned with technology-led innovation in industry and commerce Links with industry / industrial relevance (22) The applicant has published extensively in colloid science and worked in both academic and commercial environments over many years. He is especially familier with the detergent, food and related industries. Until recently, Head of Group Technical Support within the Research and Development Centre of Uni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New system for Automatic Music identification of live events and cover versions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Collective management organisations (CMO) are organisations appointed by copyright owners to administer the licensing of rights and collection of royalties coming from mechanical and public performance of their associates’ musical works. CMOs worldwide have turned into technology in order to solve music rights distribution of the royalties collected from broadcast media and internet, but there is no available solution yet to solve the problem when it comes to royalties collected from public venues (clubs, bars, pubs, etc), live events and User Generated Content (UGC).The objective of the MILC project is to to set the basis for a new innovative world-leading and cutting edge music monitoring service for public venues and on-line platforms, investigating and developing various technologies that would allow BMAT to offer a solution to this issues, and thus become the only provider, internationally, capable of monitoring and identifying music on TV, radio, venues, live concerts and internet. The success of MILC will convert BMAT as a landmark for collecting management organisations while participating in improving the transparency, efficiency and impartiality of the management and administration of royalties.BMAT is nowadays the fastest growing and world leader company in music monitoring services for CMOs, leading the international market of TV and radio monitoring services with VERICAST. With MILC, BMAT could become the global leading data provider for rights distribution. To achieve this, MILC will focus on the following objectives: 1) exploring the improvement of the fingerprint technologies used in BMAT recognition services to tackle DJing manipulation of audio, 2) reduce the complexity of the actual prototypes of identification algorithms for recognition of song re-in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Humanitarian governance: accountability, advocacy, alternatives' (HUM-GOV).

assistant: **Concept**

How is humanitarian governance evolving in response to global and local changes, and how do civil society actors and crisis-affected people shape humanitarian governance ‘from below’ using accountability and advocacy?Growing humanitarian need, increasing population displacement, and expanding impact of climate-related disasters multiply the challenges of preserving life and dignity in crisis-affected populations. At-risk populations are increasingly difficult to capture using the traditional categories of disaster/conflict victims and refugees, and humanitarian governance (attempting to govern individuals and groups to preserve life and reduce human suffering) is in flux. Changes in humanitarian governance include a paradigm shift to resilience and localization of aid reforms. As yet, these changes and their consequences are poorly understood.Through a dynamic research programme engaging at-risk populations and civil society actors, the project pursues the objectives of 1) understanding changes in humanitarian governance; 2) clarifying advocacy and accountability relations in changing landscapes of humanitarian governance; 3) identifying variations in humanitarian governance and revealing how they relate to key variables, including the type of crisis and the local context; 4) providing conceptual tools for analysing variations of humanitarian governance; and 5) addressing inequalities in humanitarian studies.Using a mixed-methods approach combining conceptual work on ethics and humanitarianism with four case studies using qualitative and participatory methods, the project will explore how the interplay of actors and contextual factors produce variations in humanitarian governance, with a special focus on how crisis-affected populations and civil society actors use accou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An open-source platform for Resilient sECure digITAL identitieS' (RECITALS).

assistant: **Concept**

RECITALS aims to build an open-source platform that integrates into a common framework a wide variety of techniques and services for privacy-preserving data sharing and identity management. The platform consists of three main modules:1) RECITALS core provides a series of fundamental components that can be used as building blocks for constructing more complex services. These include: the distributed ledger, the identity lifecycle manager, the cryptography manager, the anonymization manager as well as the compliance manager for horizontal EU legislation.2) RECITALS value-added services combine multiple components from RECITALS core into end-to-end pipelines that address specific needs: a self-sovereign wallet, privacy-preserving record linkage, privacy-preserving federated learning, LLM-based user interface, domain-specific compliance manager, privacy-preserving data analytics and explAIner, which sheds light into the decisions taken by trained ML and DL models.3) Security Manager provides all necessary means for ensuring the resilience of the entire platform. To this end, it covers all aspects of cyber-security, from the analysis of possible cyber-attacks to their automatic detection and mitigation.Special care is taken to equip each component with the state-of-the-art techniques of the corresponding task. As a result, each component acts as a library comprising a wide variety of established methods and can be used independently of the platform, for example by being integrated into any other system that leverages Python's open-source ecosystem.Another goal is to tweak the methods implemented by each component so as to enhance their time efficiency and scalability.The performance of the RECITALS platform will be tested in three demanding industrial use cases, to evaluate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Capturing tumoral drug metabolism by Cells In the Tissue Environment using spatial pharmacometabolomics' (CITE).

assistant: **Innovation**

Small molecule anti-cancerSmall molecule anti-cancer therapies generally have a well understood mechanism of action. Still, they are frequently plagued by poor efficacy and high rates of treatment resistance, especially in the context of pancreatic cancer. One promising newly recognised route of therapy resistance is intratumoral drug inactivation through members of the tumour microenvironment (TME) such as the tumour-associated microbiome. With the CITE project, I aim to develop novel analytical technologies that enable us to study drug metabolism by the TME in situ and in isolation from systemic drug metabolism and provide a novel platform for selectively studying the contribution of the TME to drug resistance mechanisms. . I will deploy a spatial pharmacometabolomics approach using Laser Desorption Rapid Evaporative Ionisation Mass Spectrometry (LD-REIMS). First, a novel and sensitive source setup including laser optics and high efficiency aerosol transfer will be developed, followed by instrumental setups for imaging applications at (sub)cellular resolution, high throughput acquisition of cell lines and thick tissue section imaging. Subsequently, a spectral database of abundant (tumour, endothelial cells, fibroblasts etc) and rare cell types (immune cells, microbiome) in the TME will be created to enable cell-type specific assignment of drug delivery and drug metabolism in mass spectrometry imaging datasets and validated using imaging mass cytometry.I will develop a organotypic culture (3D-OTC) model of pancreatic cancer to study isolated, intratumoral drug metabolism in a controlled environment while still using relevant clinical material. We will use pancreatic cancer from a genetically engineered mouse as model system to develop our novel analytical technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Next generation ultra-high-speed microwave  Photonic integrATed circuiTs using advancE hybRid iNtegration'.

assistant: **Innovation**

In PATTERN will world’s first process design kit (PDK) for microwave photonics at ultra-high frequencies above 100 GHz as well as bringing new functionalities into PIC such as magneto-optics isolators and acousto optics modulators (AOM). PATTERN’s approach to ultra-high frequencies is holistic and includes all the aspects such as design and simulation, generation, detestation, modulation, and packaging.  To achieve this goal, we propose a massive hybrid integration of several different PIC platforms such as InP and LNOI but also including new materials such as Yttrium Iron Garnet (YIG). We also develop co-integration of electronic SiGe chips with PICs which especially a necessity in ultra-high speeds.  LNOI is of the most promising emerging materials for PICs that comprises a unique set of interesting optical properties: a high electo-optic coefficient, a high intrinsic 2nd-order nonlinearity, and a large transparency window which makes it ideal for electronics manipulation of light at many wavelengths (EO modulation). InP is an ideal platform for generation and detection of light and YIG is a known magneto-optics material. If put together, truly novel, and advanced functionalities and opportunities arise. In addition, in PATTERN we developed packaging solutions and for such high frequencies which one of the main barriers in this field. Moreover, we also develop software expertise for design automation (e.g. RF signal routing) and end-to-end circuit simulation and design which is extremely challenging at these frequencies. We also demonstrate the capabilities of the platform in 6 different application-oriented prototypes.To achieve these objectives, PATTERN put together the expertise of 10 well know SMEs, RTOs and industrial players to achieve these objectives in 48 mon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Space intelligence engineering and quality network' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The ultimate goal is to offer technical support to SMEs to help them improving their skills, lowering their entry barrier to space, and fostering their competitiveness in the space and non space markets. This help will be through the use of a network of en gineers and other experts giving their support on a commercial but non-profit basis. The network, called SINEQUANET (Space Intelligence, Engineering and Quality Network), will be a genuine structuring tool, focused on technical and engineering support, i .e. on what none of the existing networks offers. As there is no need to duplicate the action of existing structures, SINEQUANET will cooperate with and use the existing networks whenever their contribution to its objective is useful. The present project covers the establishment of the network baselines, the preparation of the necessary tools for its operation, and the practical testing of its functions through case studies selected in representative fields, to obtain a fully operational SINEQUANET paving the way for a valuable impact on the SMEs sector. The network establishment will require few years and a phased approach to reach its maturity and its full potential, but SMEs will receive concrete services already during the present phase, that will allo w to validate two technologies in two of the most promising industrial fields to bridge the gap to their commercial exploitation, and will train some 100 engineers in different areas of space engineering, depending on SMEs needs. SINEQUANET is genuinely unique and valuable to SMEs, and the nature of the proposed activities is completely coherent with the ETI instrument. Considering the adoption of the White Paper on the European Space Policy , the entry into force of the framework agreement between ESA an d EC , and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Meaningful Open Schooling Connects Schools To Communities'.

assistant: **Objectives**

MOST (Meaningful Open Schooling Connects Schools To Communities) supports European school students and citizens in developing science knowledge, transversal skills and competences in working scientifically. MOST enables and encourages its target groups to pursue scientific careers and long-term,  will raise the numbers of scientists in Europe. To achieve this, our Consortium of 23 partners from 10 European countries (higher education institutions, schools, non-formal education providers, ministries, municipalities and enterprises) proposes a powerful Open Schooling idea.The project opens up formal science education and establishes partnerships between schools and their communities (families, science education providers, citizens, businesses, etc.) to work jointly on environmental school-community-projects (SCPs). These participatory projects directly respond to the needs and values of those involved, benefit the communities as a whole and make schools agents of community well-being. MOST’s learning impact is boosted through an educational research-based approach that raises interest in science, scientific literacy and environmental responsibility.MOST works on a threefold geographical structure: within communities (schools as hubs), at regional level in our 10 partner countries (connecting all open schooling communities from one region) and, ‘creates a bigger picture’ by establishing an Open Schooling Network at the European level. MOST fairs in each partner region maximise impact and strengthen regional efficacy. A final MOST Conference connects all SCPs across Europe to a vibrant science-learning network that opens up to further countries and communities.Planning and implementation involve all relevant actors: formal/non-formal education, research /practice, policy, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biohybrid Synapses for Interactive Neuronal Networks' (BRAIN-ACT).

assistant: **Innovation**

BRAIN-ACT aims to develop the next generation of interactive biohybrid devices which will couple biological neuronal networks to organic artificial neurons. For the first time, neurons will interact with the device by active mechanical reshaping which will transduce in the maintenance of the electrical network connection strength (long term potentiation –LTP). This will be achieved by a) processing dynamic electroactive materials b) engineering the neuromorphic abiotic surface with biological synaptic receptors and c) intergrate an in vitro biohybrid synapses array to investigate the interplay at the interface between neuronal cells and their synaptic activity with dynamic electrically-smart materials. BRAIN-ACT will pave the way for a new class of chip-based smart bioelectronic devices which will ‘have a shape of a neuron and act like a neuron’. Over 10 million people are affected by neurodegenerative diseases like Parkinson’s and Alzheimer’s worldwide and show significant loss of functionalities in their daily life. Those are mainly related to faulty connections within the brain which reflects neuronal miscommunication regulated by billions of individual connections among pairs called synapses. The ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity is called synaptic plasticity and is regulated through electrical and biomechanical signals exchanged by neurons pairs. In vitro bioelectronic platforms have been devoted to monitor and stimulate those signals across neuronal network areas to characterize electrical activity and connectivity in a passive manner. BRAIN-ACT will revolutionize the study of in vitro neuronal networks through active mechanical reshaping to establish optimal electrical signal exchange am