RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Psychosystems: Consolidating Network Approaches to Psychopathology' (Psychosystems) targeting Horizon 2020.

assistant: **Abstract**

I have recently introduced the Network Approach to Psychopathology. This approach is based on the interpretation of mental disorders as causal systems. Such systems have two basic building blocks: symptoms (i.e., problems like insomnia, fatigue, and concentration problems) and connections between symptoms (i.e., causal and homeostatic relations, such as insomnia → fatigue → concentration problems). Together, these building blocks constitute a network, which can be analyzed as a complex system. I have successfully used this approach to explain important phenomena in psychopathology research, such as comorbidity, spontaneous recovery, and prevalence differences between disorders. In addition, I have invented techniques to identify dynamic network structures from time series data, as obtained through experience sampling methodology. This proposal consolidates the Network Approach to Psychopathology through (a) further development and testing of methodologies, and (b) applications of the model to important research domains in clinical psychology. The project is structured in two postdoc projects and two Ph. D. projects. Postdoc project Network estimation and control develops analysis techniques for the estimation of large symptom networks. Postdoc project Early warning signals and transitions investigates whether transitions in symptom networks can be predicted using early warning signals, such as critical slowing down. Ph. D. project Resilience and vulnerability tests the hypothesis that more strongly connected networks are more vulnerable to disorders and investigates whether depressive episodes lead to prolonged changes in network structure. Ph. D. project The dark matter of psychopathology investigates the role of ""anti-symptoms"" – networks of positive factors that ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'INnate-ImmunomeTabolIsm as Antiviral TargEt' (INITIATE) under Horizon 2020.

assistant: **Objectives**

Viral outbreaks and epidemics continue to impose high morbidity and mortality burdens in mankind and animals, emphasizing the urgent need for the continuous improvement and innovation of our antiviral strategies. The innate immune system is pivotal for effective anti-viral defences. This field is now being revolutionised by the recognition that metabolic re-programming has a major impact on the host antiviral and inflammatory response to virus infections. The development of strategies targeted to these pathways represents an exciting new frontier for antiviral remedies. To drive this emerging field of antiviral immunometabolism and its application to viral diseases, INITIATE (INnate-ImmunomeTabolIsm as Antiviral TargEt)  brings together a highly complementary  team of world leaders, both academic and corporate, from the historically distinct research fields of virology,  innate immunity and cellular metabolism in order to train a new generation of interdisciplinary scientists. Specifically, INITIATE will deliver training on the interrelationships between viral infection, host metabolism and immune defences through related and interdependent research projects, complemented with interdisciplinary and intersectoral secondments. Local and network-wide scientific workshops will be supplemented with transferrable skill workshops devoted to academia/industry collaboration, research dissemination and translation of knowledge into novel therapeutic interventions, public engagement and a successful research environment. INITIATE will result in a new generation of creative, entrepreneurial and innovative top-level interdisciplinary researchers, who will be at the forefront of the emerging research field of ‘antiviral immunometabolism’. These scientists will be able to face the ine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engineering light induced phase change for emerging nanoscale processes' (NanoLPC) under Horizon Europe.

assistant: **Objectives**

Light-induced phase change (LPC) is the unifying theme underpinning many apparently non-related  processes in i) additive manufacturing (AM) for metals where laser induced vaporisation and the formation of keyhole porosity is a major limiting factor for 3D printing, ii) nanomedicine (NM) where laser induced nanobubble dynamics and associated shockwave effect is powerful for malicious cell destruction, and iii) solar energy (EN) where direct steam /vapor production from bulk and surface fluid is a promising technology for power and clean water solutions.  In addition to the challenging multiscale nature of phase change, LPC add further complexities by introducing the multiphysics nature due to strong light-absorber interactions. We will tackle the fundamental challenge of the formation and control of LPC and develop a physics-based platform, supported by multiscale experimentation and multiscale simulation, as the tool to design and engineer LPC as innovative mechanism for in situ process steering and control. Five work programs are designed focusing on two complementary paradigms: i) fundamental studies for enhancing LPC mechanism understanding via developing physics-informed multiscale modelling validated by dedicated nanoscale experiments, and ii) application studies for engineering LPC for designed functions towards EN, NM and AM respectively. Many breakthroughs beyond state-of-art work are expected, such as i) the establishment of a unique multi-physics and multiscale LPC simulation platform; ii) the revelation of LPC mechanisms by sub 100 nm experiments with localized temperature and nanobubble dynamics measurement; and iii) the reverse engineering of LPC to maximize solar vapor production, inhibit keyhole pore formation and control nanobubble shockwave effects. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New sit-stand chair for industrial workplaces' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The main aim of this project is the development of a new line of sit-stand seats able to reduce significantly the problems reported in different workplaces with intermediate mobility and force exertion such as light assembly industries. These sit-stand seats will be highly adaptable to the variability of the workplaces involved by means of a modular approach and the worker acceptability will be a key factor in the design. This aim is developed in the following goals of the project:1) Determination of the functions (movements, reaches) in typical workplaces for sit-stand seats. 2) Analysis of the load supported by workers as a function of support possibilities (standing, intermediate postures and conventional sitting).3) Setting up of biomechanical models for optimal comfort, safety and health. 4) Turning into design criteria the biomechanical and subjective optima from the models. 5) Complete development of product including economics, manufacturing and materials.6) Prototypes construction. Validation by workers in real workplaces.7) Final design criteria and specification of the product for industrial production.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Combination of Shear Stress and Molecular Imaging of Inflammation to Predict High-Risk Atherosclerotic Plaque'.

assistant: **Objectives**

Although the detailed pathophysiologic triggers responsible for the individual natural history trajectory of each atherosclerotic plaque are unknown, the local, dynamic interplay between low endothelial shear stress (ESS) and vascular inflammation is likely to be critical. The purpose of the proposed project is to combine ESS with inflammation in a plaque risk classification scheme aiming to predict high-risk plaque at early stages of its development before its rupture. Enhancing our understanding of the magnitude of local hemodynamic stimulus with respect to inflammation (i.e. ESS), as well as the extent of local inflammation would allow us to detect early, minimally stenotic, atherosclerotic lesions and stratify the risk of them evolving into high-risk plaques. The latter classification is of utmost clinical importance as it can provide a rationale for innovative diagnostic and/or therapeutic strategies for the management of coronary patients, as well as the prevention of acute coronary syndrome. Identification of a high-risk plaque at its early stages of development would potentially justify highly selective, prophylactic local interventions, such as implantation of stents or targeted nanoparticle-based delivery of anti-inflammatory drugs, supplemented by an intensive systemic pharmacologic approach to limit the severity of inflammation, stabilize the plaque, and thereby avert a future acute coronary event. The clinical and economic implications of identifying and treating high-risk individual coronary lesions before an adverse cardiac event can occur are anticipated to be enormous.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'De-railing scaling: From fundamentals of crystallization fouling on nano-materials to rational design of scale-phobic surfaces'.

assistant: **Objectives**

Crystallization fouling, a process where scale forms on surfaces, is pervasive in nature and technology, negatively impacting the energy conversion and water treatment industries. Despite significant efforts, rationally designed materials that are intrinsically resistant to crystallization fouling without the use of active methods like antiscalant additives (which can persist long after their disposal and the toxicological impact of which in effluent is questioned) remain elusive. This is because antiscalant surfaces are constructed today without sufficient reliance on an intricate but necessary science-base, of how interweaved interfacial thermofluidics, nucleation thermodynamics, and surface nanoengineering control the onset of nucleation and adhesion of frequently encountered scaling salts like calcium carbonate and calcium sulfate. Such scaling salts are common components of fouling deposits in industrial heat exchangers and membranes, which significantly inhibit heat transfer and flow performance. Therefore, guided by interfacial thermofluidic and thermodynamics theories, and employing advanced experimental methods in the areas of surface nanoengineering and diagnostics, this project will develop an integrated knowledge-base for how engineered surfaces can beneficially interact with interfacial transport phenomena in order to significantly advance antiscalant surfaces. We aim to pinpoint mechanisms for inhibiting scale nucleation and reducing adhesion in order to design and engineer antiscalant materials based on the collaborative action of their composition and topography. The effects of surface texture curvature, surface composition, and substrate compliance on scale nucleation and adhesion have intertwined and sometimes competing impacts, which we aim at elucida
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Novel insights into the sensing of salt stress in plants: understanding the relationship between salt stress response and cytosolic pH changes.'.

assistant: **Innovation**

The Salt Overly Sensitive (SOS) pathway is one of the main regulatory systems responsible for Na homeostasis in plants. The SOS pathway is activated by salt stress and comprises three core components: SOS1, SOS2 and SOS3. SOS3 is a calcium (Ca) sensor that perceives the increase of intracellular Ca triggered by salt stress and recruits SOS2, a Ser/Thr protein kinase, to the PM. The complex activates protein SOS1 by phosphorylation, a PM-localized Na/H antiporter that prevents the accumulation of Na to toxic levels and regulates Na partition between roots and shoots. Cytosolic free Ca is a common second messenger in the signalling of a variety of abiotic stresses. The wide range of Ca-activated responses lead us to posit the existence of additional mechanisms relaying input signals that, together with this Ca signature, would initiate the specific response for a particular stress. The hypothesis of my proposal is that the increase in intracellular Na concentration provokes the alkalinisation of the intracellular pH, what would be sensed by SOS3. SOS3 would work as pH and Ca sensor, which would integrate this pH shift and the Ca signature to activate SOS pathway.To support the hypothesis of cytosolic alkalinisation as a salt stress signal and SOS3 as a Ca and pH sensor, two experimental criteria must be meet: (1) salinity should induce an alkaline pH shift in plant cells, and (2) structural determinants of pH-sensing should be demonstrated in SOS3. To achieve my goal: (1) I will use a system, improved by Prof. Schumacher’s group, which allows the visualisation of pH changes in selected subcellular localisations through fluorescence ratio imaging experiments; and (2) I will use the technics learned and used duiring my postdoct stage to study whether SOS3 interactions and/o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bent-Core Liquid Crystals & Tailored Aggregates and Nanostructures Generated Orthogonally' to be submitted under Horizon Europe.

assistant: **Abstract**

Europe faces the imperatives of green and digital transition, continually seeking novel nanoscale materials. Smart soft nanomaterials, with their responsiveness to stimuli open a wide range of application to meet industrial and societal challenges, while supramolecular chemistry enables tailoring captivating architectures and functionalities. For the goal of closing research-technology loop, BCLC-TANGO’s objective is to develop innovative functional soft materials through leveraging the orthogonal “self-assembly dancing” of bent-core molecules, with focus on BC liquid crystals and tailored aggregates and nanostructures, as well as on the exploration of suitable processing options.In this Marie Skłodowska-Curie Action, Dr. Mašulović will receive crucial training at the Instituto de Nanociencia y Materiales de Aragón (INMA)-University of Zaragoza, under the supervision of Prof. Maria Blanca Ros. Fundamental approach of organic synthesis and supramolecular chemistry will be used, along with modern techniques of material and nanoscience to design and synthesize novel bent-core molecules (1), to broadly characterize them exploring functional properties suitable for application (2) and increase their real applied potential through processing (3). During 6 months of secondment at the Institute for Molecular Systems Engineering and Advanced Materials, University of Heidelberg, under supervision of Prof. Eva Blasco, she will explore a novel approach of 3D/4D printing for some of these supramolecular materials as one of the processing methods. This project will pave the way for the development of easily manipulable smart soft nanomaterials, with tunable properties, having a far-reaching implication for industries. In addition to promoting women education in STEM, the fellowship w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploration and promotion of neurogenesis in the adult brain' (Neurogenesis) under Horizon 2020.

assistant: **Objectives**

It is now well established that new neurons are added to certain regions of the adult brain. There is today considerable interest in the development of regenerative therapies based on modulating endogenous neurogenesis, but it is necessary to better understand these events to assess whether this is rational and realistic. This application takes its initiation in two recent discoveries that we have made: that astrocytes in the mouse striatum give rise to new neurons after stroke or inhibition of Notch signaling (Magnusson et al., Science, 2014) and that neurogenesis is a continuous process in the human striatum throughout adulthood (Ernst et al., Cell, 2014). We propose to characterize the molecular regulation of neurogenesis from striatal astrocytes in detail, and compare these astrocytes with those in other regions to understand why striatal astrocytes are uniquely neurogenic and whether astrocytes in other parts of the brain can be induced to give rise to new neurons. We will, moreover, assess the role of integration of new neurons in the striatal circuitry by inducing neurogenesis in the striatum in adult mice by blocking Notch signaling or by inducing stroke and modulate the activity of the new neurons by optogenetics and chemogenetics. We will, furthermore, study whether striatal neurogenesis is altered in human neurological diseases by retrospective birth dating by measuring the integration of 14C from nuclear bomb tests. We will assess whether inducing striatal neurogenesis in corresponding mouse models of neurological diseases has therapeutic potential. This project will elucidate the molecular regulation of neurogenesis from astrocytes and the neurogenic potential of astrocytes in different parts of the brain, reveal the role of new neurons in the striatum, ans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Channelfree liquid crystal microfluidics' in the context of a Seventh Framework call.

assistant: **Objectives**

FREEFLUID is a multidisciplinary research project aimed at a vibrant scientific field of complex soft matter, introducing microscopic flow threads and flow networks as programmable microscopic elements. We propose a novel approach –channelfree liquid crystal microfluidics- which combines the internal structure of the fluid with external stimuli to generate microscopic flow streams in a bulk fluid. With no channels, the approach generates flow which is directional, anisotropic, variably strong, and can be propelled with various external stimuli including electric, magnetic, and surface fields. The key advantages of channelfree microfluidics are its inherent programmability, reconfigurability, tunability, being moving-part-free, and the obvious no need for fabrication of channels and channel networks. The subtle backflow coupling of the flow to the orientational order of the fluid suggests strong potency for interesting applications, such as topological flow networks, hierarchically reconfigurable flow profiles, and flow assisted self-assembly of colloidal structures. The approach will be worked on by continuum mesoscopic modelling based on generalized liquid crystalline dynamics, combined with collaborative experiments. After the period of mobility, the wide outreach of the proposed research will lastingly integrate the researcher and offer him continuing professional development. The researcher will build upon his scientific excellence and train in scientific in non-scientific skills. FREEFLUID will be implemented at University of Ljubljana, renown in soft matter community for ingenuity and highest scientific standards. Integration of the researcher will transfer knowledge and create cohesion at bi-lateral and Community level. Strong ties with European and global scient