RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Knowledge-based energy management for public buildings through holistic information modeling and 3D visualization'.

assistant: **Objectives**

Energy efficiency in the building sector through intelligent energy management is a key measure for the global reduction of greenhouse gas emitted by this sector and additionally facilitates user costs reduction in the context of growing energy prices and harshness of natural resources.The KnoholEM project's aim is the engineering of an intelligent energy management solution that will considerably reduce energy consumption, both by systematically avoiding energy wasting in buildings and by knowledge-based holistic optimization of energy consumption. The solution will be applicable and configurable for a broadband of building types from any EU region.The intelligent energy management solution will be based on existing knowledge representation technologies like functional modeling and ontology, which will be used in the context of smart buildings in combination with Building Automation Systems. It will be enhanced by energy consumption behavior simulation with realistic visualization assistance. Approaches previously developed by the project partners will be integrated into a holistic intelligent energy management solution.The focus of the project will not be on development, but on detailed analysis and validation. KnoholEM includes four types of demonstration objects in Spain and the Netherlands that will be used by the consortium of industry and research partners to develop, enhance and extensively test the solution. An overall knowledge base will be created through a detailed analysis of the structure of the demonstration object buildings and their energy consuming/producing devices, through the intelligent interlinking of building usage with its energy demand, as well as by various energy consumption behavior simulations.Through the knowledge accumulated within the ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The power of quantum computers' (QUCO).

assistant: **Innovation**

Quantum computation has been put forward as a way to overcome current computational limits, by exploiting the quantum properties of nature. It is an interdisciplinary area at the interface of physics and computation. Since Shor's groundbreaking discovery in 1994 that a quantum computer can factor numbers efficiently, strong, steady advances have been made in understanding the advantages of quantum resources and numerous experimental efforts are underway to implement this model of computation. Our research goal is to expand our understanding of quantum resources and computation and its interplay with classical computation, as well as to open new directions. More specifically, we want to advance progress in algorithm design, using new paradigms we have recently helped to develop, and to deepen our understanding of the computational power of physical resources like shared quantum states (entanglement), quantum communication, quantum memory and restricted quantum systems. An important aspect of this proposal is to parallel this investigation into the power of quantum systems with a study of its limits. Specifically we want to identify potential hard problems for quantum computers and to explore their hardness properties as a base for new classical cryptosystems that are secure against quantum adversaries. We also want to deepen our understanding of the effects of an adversary with quantum resources in cryptography. In a society where information is a crucial economic resource it is important to protect today's information against tomorrow's possible progress in the implementation of quantum computers. In this line of research we also propose to explore the systematic use of the emerging toolbox of quantum techniques to find solutions for classical problems with quantum argu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'THz-FIR Colour Imaging of Skin Condition Based on Analysis of Its Thermal Emission' (THz-Skin).

assistant: **Concept**

In the EU skin cancer causes 36,000 deaths per year and €9 billion in healthcare and indirect costs.  Diagnosis relies on expensive tools and specialists, thus preventing mass screening to improve patient outcomes and costs. THz-Skin addresses this by developing a platform that merges advanced detection technology with unique spectroscopic data for effective, accessible diagnostics. We build on the well established fact that cancer biomarkers manifest as spectral fingerprints in the terahertz-far infrared range. By resolving these features from body thermal emission, we achieve real-time, zero-radiation, non-invasive, label-free cancer diagnostics – a real breakthrough in early skin cancer detection.Our platform blends high-performance, miniaturized sensors with a large, open-access spectral fingerprint library of skin conditions.  Inspired by the RGB model for visible light, our Multifrequency Pixels (MFPs) decompose skin thermal emission into spectral bands in the 3-25 THz range, where biomolecular cancer signatures occur. Our MFPs consist of compact, low-cost micromechanical bolometers fitted with frequency-selective metasurfaces, achieving high sensitivity and body thermal radiation analysis without cryogenics or bulky spectrometers.  Diagnostic capabilities can be continuously improved by optimising MFP architecture and expanding our spectral library with simulated and experimental data.  Our platform is designed for scalability, affordability and broad deployment in primary care settings. It is also designed to integrate with AI diagnostic tools, adding sub-cutaneous, cancer specific information to standard camera images.  To ensure real-world readiness, our system will undergo in vivo validation using animal models, demonstrating its diagnostic performance in bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Euro-mediterranean wildland fire laboratory, a wall-less" laboratory for wildland fire sciences and technologies in the euro-mediterranean region"' in the context of a Fifth Framework call.

assistant: **Objectives**

The enhancement of the wild land fires sciences and technologies, and the rapid and systematic transfer towards end-users and stakeholders, incite to create this laboratory" for effectively creating a European Research Area in the wild land fire domains. EU Fire Lab is structured in units (work-packages) for (i) reinforcing the co-operation among Euro-Mediterranean teams, (ii) activating large exchanges of knowledge and know-how, (iii) developing common concepts, approaches, and "languages", (iv) fostering the common use of facilities for research and/or technological development, and so, (v) avoiding unnecessary and expensive replications in Fuel description and modelling, Fire behaviour modelling, Fire, ecosystems functioning, and bio-diversity, Socio-economy, Decision support tools, Fire measurements methods, Fire risks and hazards, Fire suppression, Interfaces management. EU Fire Lab Observatory of wild land fire sciences and an innovative Web site enabling close connections between EU Fire Lab members and with the public ensure a large dissemination and valorisation of EU Fire Lab achievements towards the end-users and stakeholders."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European clinical research infrastructures network for clinical trials and biotherapy - preparatory phase for the infrastructure' in the context of a Seventh Framework call.

assistant: **Objectives**

European clinical research needs an integrated and distributed infrastructure able to provide efficient support to multinational clinical trials, taking advantage of the European population and competencies, unlocking latent expertise and patients scattered across the EU member states. ECRIN (European Clinical Research Infrastructures Network) is designed to bridge the fragmentation of clinical research in Europe through the connection of national networks of clinical research centres and clinical trial units. Participants are currently Austria, Denmark, Finland, France, Germany, Hungary, Ireland, Italy, Spain, Sweden, Switzerland, the United Kingdom, and the EORTC. It will provide integrated, ‘one-stop shop’ services to investigators and sponsors in multinational studies (patient recruitment and investigation, data management, GMP manufacturing of biotherapy products, quality assurance, monitoring, ethics, regulatory affairs and adverse event reporting). With this objective, the preparation phase will consist of - WP2: selection of a legal status and of the governance structure - WP3: agreement on a financial plan leading to a long-term sustainability during the construction step and the operation phase - WP4: survey on needs in terms of GMP facilities for biopharmaceuticals and biotherapy, and their design. - WP5: education programme for multinational clinical studies - WP6: extension to other EU member states - WP7: capacity building to help national networks fulfil the sponsor’s tasks - WP8: update and upgrade of the quality assurance system - WP9: internal and external communication - WP10: accreditation of data centres - WP11: support to pilot projects Users will be investigators and sponsors in the academic and SME sector. Participants will be the national coordi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inequalities in Lifespans before and after Retirement: Trailblazing Demographic Theory and Analysis' (2014-2020) under Horizon 2020.

assistant: **Objectives**

How unequal are lifespans at older ages? How unequal will they be in the future? The length of life is often summarized by life expectancy, but the mean does not capture the spread. Distributions of lifespans need to be analyzed and forecast. Given the relevance of such research—for assessing pension reforms and other social and health policies—it is remarkable how little demographic modeling has been devoted to inequalities at older ages in individual lifespans. The research proposed here has three audacious ambitions and bold theoretical thrusts: (1) broaden discourse and conceptually shift thinking about retirement to include individual lifespan inequalities, (2) developing the demographic theory of old-age mortality, test the hypothesis that substantial progress is being made in cutting death rates after age 90, and (3) develop an innovative theory-based forecasting method based on 8 strong regularities of mortality trajectories at older ages that goes well beyond the state of the art to predict lifespan distributions (and inequalities)—and to quantify the uncertainties in these predictions. Preliminary research, mostly on Denmark but also some on Sweden, France and Japan, to prepare this application produced findings that surprised me. The probability of dying after age 50 but before retirement age was higher than I suspected. The likely growth in the number of people above age 90 astonished me. Rates of improvement in mortality after age 100 in France and Japan were much greater than published estimates for Denmark or Sweden. Current forecasting methods appear inadequate to capture likely reductions in death rates at the ages when most people die. These preliminary findings suggest that the daring theory-based, theory-building program of analysis of 40+ countries/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'RESILIENT INFRASTRUCTURE AND BUILDING SECURITY' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The RIBS-project supports the design of effective and viable integrated security measures aimed at protecting infrastructures without impacting on their business dynamics. In a global context where national interests are increasingly interrelated, the most vulnerable infrastructures in Europe, and particularly the most critical ones, are primary targets for terrorists. Attacks, carried out under a national, political, or religious banner, now strike regularly in our cities, causing deaths, damage and disruption on an unprecedented scale. In the past seven years alone, 1300 terrorist incidents have taken place on European soil. The RIBS project will deliver more effective and viable security measures by supporting a design process that integrates a broader understanding of the environment (and the contextual factors such as human elements) within which these measures are meant to be implemented. The particular objectives of the project include: • a set of functional and non-functional requirements that will drive an effective security system design process. • a set of protection measurement techniques that can be used to assess the level of protection offered by candidate security products proposed to be implemented in buildings and infrastructures. This work will be carried out for a range of security systems aimed at securing buildings against hostile reconnaissance, intruders and hazardous attack (including chemical, biological and explosive). The RIBS-project will derive a scientific method for security system engineering design that can be challenged and improved over the years, similarly to other areas of engineering and physical sciences. • Phase 1: Study of a 'live' building and its ‘eco-system’, its protection measures, and threats; and integration of these elem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accelerating ERA by Sharing Unique Talents for healThy Life and Environment' (2021-2027) under Horizon Europe.

assistant: **Objectives**

ERA_SHUTLLE is creating a cross-sectoral framework for collaboration and possibilities for talents from different backgrounds to address contemporary health and environmental challenges and produce innovative solutions for the benefit of society. The ERA_SHUTTLE's main goal is to foster R&I capacity in the ERA to benefit the participating widening countries Poland, Croatia, and Malta. This will be accomplished by bolstering R&I support capacities, boosting cross-sectoral collaboration, and implementing cross-sectoral knowledge valorisation and talent circulation experiments while boosting the attractiveness of regional R&I ecosystems. This action is designed by leading research universities from widening countries with underdeveloped RI landscapes and strong non-academic institutions and associations from non-widening countries such as Steinbeis, CERIC-ERIC and ASTP. The ERA_SHUTTLE brings universities, non-academic, and private organisations together to eliminate existing barriers and work toward a common objective by offering training and secondment opportunities that celebrate diversity. Project partners will develop their core capacities and benefit from ERA knowledge and expertise exchange. The project supports industry-research needs by cross-fertilizing ideas to address hurdles and low levels of research valorisation. Following the European Industrial Strategy and the European Skills Agenda, ERA_SHUTTLE will help R&I talents from Widening countries deepen their capacity and broaden their skill set to improve research, knowledge valorisation, and cross-sectoral collaboration. Through specific objectives, project will: identify research institutions' strengths and weaknesses and increase access, integration, and use of research equipment and knowledge, improve rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Toward the Commercialization of a Proteolytically Resistant APPI Variant for Inhibiting Metastasis in Prostate and Pancreatic Cancer' under Horizon 2020.

assistant: **Concept**

Distal site tumor metastasis is the leading cause of prostate- and pancreatic-cancer-related deaths; nevertheless, standard-of-care (SoC) treatments and other targeted therapies under development are based on their activity against the primary tumors rather than on their anti-metastatic activity. There is consequently an urgent medical need for new agents targeting the metastatic process. In prostate and pancreatic cancer models, the serine protease mesotrypsin promotes tumor invasion and metastasis, making it an attractive target for therapeutic intervention. In our ERC StG project, we used directed evolution to generate a novel prototype mesotrypsin inhibitor, designated APPI-3M, which is based on the human amyloid β-protein precursor Kunitz protease inhibitor domain (APPI) scaffold. This inhibitor has picomolar affinity, enhanced binding specificity and improved proteolytic resistance to mesotrypsin and exhibits high potency in cell-based and preclinical models of prostate cancer invasion and metastasis. In this PoC proposal, we propose to perform final lead optimization (particularly decreasing body clearance) of APPI-3M towards its commercialization for clinical translation as an antimetastatic therapeutic adjuvant, with the direct involvement in the planning stage of clinicians and other key opinion leaders in the field. The feedback of these experts is expected to confirm the need to address the problem of metastatic progression and to identify potential indications and therapeutic windows for the use of APPI-3M as a neoadjuvant in prostate and pancreatic cancers. This input will be translated into feasible preclinical studies to demonstrate the contribution of APPI-3M therapy to currently ongoing SoC protocols for prostate and pancreatic cancers. In parallel, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Deciphering how microbiota modulate anti-tumor immune responses in checkpoint therapy' (MIMIC) targeting Horizon 2020.

assistant: **Abstract**

Microbiota has a major impact on anti-tumor immune responses and efficacy of anticancer treatments. These effects are thought to be mediated by modulation of tumor-infiltrating myeloid cells. These include immunosuppressive macrophages that differentiate from inflammatory monocytes recruited to the tumor. However, what microbiota-derived products are required for efficient anti-tumoral responses is still unclear. We have recently identified the Aryl Hydrocarbon Receptor (AhR) as a key suppressor of monocyte-to-macrophage differentiation. AhR is a ligand-activated transcription factor sensing metabolites derived mainly from dietary intake and microbiota metabolism. Based on our previous work, we hypothesize that AhR is involved in the modulation of anti-tumoral responses by the microbiota, via the regulation of immune cells differentiation or function. The objective of the project is to address whether AhR ligands mediate the impact of microbiota on anti-tumor responses in anti-checkpoint therapy and to determine the cellular mechanisms involved. To address it, we will analyse anti-tumor immune responses in groups of mice with normal or altered microbiota, treated or not with anticheckpoint therapy, fed with a control diet or supplemented for AhR ligands. We will combine two complimentary approaches, employing antibiotics to deplete the microbiota or using germfree mice. The efficacy of immunotherapies using checkpoint inhibitors is greatly reduced in patients who receive antibiotics. This is a major issue as antibiotics are commonly prescribed to prevent or treat infections in cancer patients, who may be vulnerable. This research project will provide critical novel insight into the complex interplay between microbiota and anti-tumor immune responses. Results from this p