RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Positive allosteric modulators of the PD-1•PD-L1 interaction as a new mode of therapeutic intervention for autoimmune diseases: preclinical proof of concept in humanized mice' (PAMinMICE) targeting Horizon Europe.

assistant: **Abstract**

The immune system's balance in fighting infections or cancer while avoiding autoimmune reactions is regulated by co-inhibitory and co-stimulatory immune checkpoints (ICs). ICs are major drug targets in immunotherapy, with antibodies (Abs) blocking inhibitory ICs to fight cancer, and Abs blocking stimulatory ICs in clinical trials for autoimmune diseases.Surprisingly, but likely fuelled by the worldwide focus on IC inhibitors, the field largely ignored that ICs are genuine transmembrane receptors that transmit signals upon binding of an extracellular ligand. This leaves unexplored modes of therapeutic intervention that we uncover in my granted ERC-2023-ADG by validating allosteric Nanobodies (Nbs) that bind and stabilize ICs, to agonize their activity as first-in-class allosteric modulators, thus tipping the immune homeostasis balance opposite to IC inhibitors for treating autoimmunity.Recently, we discovered the first-ever positive allosteric modulators (PAMs) of an IC and characterized several PAMs of the human PD-1•PD-L1 complex that agonize PD-L1 binding to PD-1 (affinity) and stimulate IC signalling (efficacy) in a spatio-temporal-selective and pathway-selective manner. Building on these exceptional proof of concept data, I’m founding our next integrated drug discovery company focussing on allosteric immunotherapies as a new mode of therapeutic intervention.With PAMinMICE, I will perform pioneering experiments in animal models and test positive allosteric modulation of the PD-1•PD-L1 interaction in double-humanized PD-1•PD-L1 knock-in mice as a new mode of therapeutic intervention for diverse autoimmune diseases: psoriasis, colitis, atopic dermatitis, lupus, rheumatoid arthritis. This study may provide the first preclinical evidence supporting the use of allosteric
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '(Multi-) Senor Offshore Safety system' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Offshore activities including maritime transport faces the inherent risk of loss of humans at sea. This activity proposes to develop a multi-sensor network solution that has several means to detect, characterise, classify and track humans going overboard in an all environmental conditions. The solution will adapt several sensor technologies that all have the ability to support the solution under various environmental conditions. If used jointly and in-combination the total capability will prove reliable with a very low false-alarm rate. The project will develop the prototype solution and demonstrate the viability thereof jointly with leading end-users in the maritime industries. The three leading SMEs will receive the industrial designs (including all IPR) of the total system and the end-users will have rights to use the system developed during the project. Three industrial RTD-performers are selected to perform the majority of the cost-reduction and industrialization work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The fundamentals of cardiovascular calcification: from cells to therapy'.

assistant: **Objectives**

With this project I propose to identify fundamental mechanisms of cardiovascular calcification (CVC) and new therapeutic targets using zebrafish as a model system.CVC, characterised by progressive calcification of the soft tissue causing impaired blood circulation, is a frequent form of cardiovascular disease.  Because the pathophysiology of CVC is highly heterogeneous, the exact cell types and signalling pathways triggering tissue calcification are still unknown, thus limiting therapy options.  Most studies on CVC rely on in vitro systems, which fail to reproduce the multicellular environment, or mammalian in vivo models, limited for live-imaging and high-throughput analyses.  By combining my expertise in cardiovascular research and bone biology, I propose to use zebrafish as a model to elucidate the multifactorial mechanisms of CVC, focusing on different developmental stages and cardiovascular tissues.  In Aim 1, I will use a broad array of zebrafish genetic models to characterise the cellular dynamics, molecular mechanisms and functional impact of CVC in vivo.  I will also study the role of specific cell populations present in regenerating valves and human valve implants with CVC.  In Aim 2, I propose to identify new local and systemic therapeutic strategies to block/reverse CVC, taking advantage of the zebrafish amenability for genetic manipulation and high-throughput screening.  I will recruit bone-degrading cells to the CVC site and determine their potential to reverse tissue calcification.  Moreover, I will select a short list of small molecules identified in a large-scale screen in zebrafish and will test their therapeutic potential in cardiovascular cells derived from hiPSCs of CVC patients.Altogether, with this interdisciplinary approach, I expect to bring a n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'RNA interference and plant cell-to-cell silencing signal' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

RNA silencing refers to the suppression of gene expression through nucleotide sequence-specific interactions that are mediated by 21-25nt-long RNA molecules, referred to as short interfering (si)RNAs. This process serves fundamental biological functions, including antiviral defence, developmental patterning and maintenance of genome integrity.In plants and in some animals, the effects of post-transcriptional RNA silencing can extend beyond its sites of initiation, owing to the movement of signal molecules. Although the mechanisms and channels involved are different, plant and animal silencing signals must have RNA components that account for the nucleotide sequence-specificity of their effects.A genetic screen carried out in the host laboratory has led to the identification of three silencing movement deficient (smd1,2,3) mutants of Arabidopsis that sustain cell-autonomous silencing but fail to display plamodesmal movement of silencing from vascular to mesophyll cells. In a first part of the project, the cell-cell and long-distance movement of viruses, proteins and phloem-transported dyes will be studied in smd backgrounds to determine if the mutations affect macromolecular trafficking and plasmodesmata aperture.Biolistically-triggered RNA silencing will al so be employed to analyse the effect of smd mutations is manifested in non-vascular cells. In parallel, positional cloning of smd3 will be initiated, using an available mapping population. In the second part, we will investigate the impact, on silencing movement, of known mutations affecting RNA silencing components and host factors required for macromolecule and virus movement.The third aspect will be focus on the recently identified trans-acting (ta)siRNAs in Arabidopsis. Could tasiRNAs act as non cell-autonomous r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Deciphering intrarenal communication to unvail mechanisms of chronic kidney diseases'.

assistant: **Objectives**

Chronic kidney disease (CKD) is a major cause of morbidity and mortality, affecting over 10 % of the adult population. Regardless of the primary case, the progressed stage is characterized by scarring of all anatomical elements of the kidney - glomeruli, tubulointerstitium, and vasculature, referred to as renal fibrosis. Tubulointerstitial fibrosis has largely been viewed as a consequence of glomerular scarring, reflecting hypoxia downstream from the scarred glomeruli. Novel data suggest that an ongoing communication between the glomerular and tubular compartments (tubuloglomerular feedback) plays an important role in the progression of renal fibrosis. Particularly, injury to the tubular compartments leads to more pronounced glomerular injury in the future. DIE_CKD is designed to uncover the range and mechanisms of tubular injuries involved in the pathogenic tubuloglomerular feedback. To achieve the project objectives, double/quadruple transgenic mice with the possibility of time-dependent, subsequent injury to different compartments of the kidney will be used. This unique approach will enable a direct study of how the injury to tubular compartments predisposes glomeruli to more severe injury. Detailed analysis of the mechanisms behind these effects will be performed. The experimental data will be further confirmed in human renal biopsies of patients with Fabry disease with progressed CKD and renal fibrosis. Comprehensive histopathological assessment of long-term prognosis of sequential biopsies will be performed to analyze the involvement of individual compartments over time.


**Keywords:** chronic kidney disease, renal fibrosis, PAI-1, Fabry nephropathy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Indra HVDC Distribution system' (INDIS) targeting Horizon 2020.

assistant: **Abstract**

The INIDIS proposal, presented by INDRA SISTEMAS, try to answer in the best way the call JTI-CS2-2016-CFP04-SYS-03-07.The proposal is based in the prototype development for a new electrical power distribution system (or n-EPDS) to be placed in small aircraft and helicopter.The main challenges of the project is to perform the main power distribution in HV (270Vdc) to gain advantages of this electrical characteristics in small aircraft (low-medium installed power). And in order to improve the operability in this new EPDS, the traditional contactors will be replaced by new smart-contactors (E-HVContactor) and with high power solid state switching (HVHP-SSPC)s. Moreover, as aditional challenge and linked with the evolution of the new switching devices, the EPDS will implement an intelligent power management function (or IPMS) that will be in charge to optimize power demand, power installed and load sheeding.The proposal is framed inside of the SYS-ITD of the CleanSky2 program, and at the end of the project, a dedicated prototype will be delivered to the topic mangaer rig test for integration activities and integration tests.The project is based in 5 WPs (Definition and preliminary dTo esign, development, testing, Optimization and support of TM Rig tests and Project management and dissemination).Two protopypes + subassemblies will be manufactured for internal tests and for delivery to TM Rig Tests.Although this is the Indra proposal, Indra will open to rework proposal during negotiation phase and specification availabilityaccording to the necesities of the topic manager and the SYS-ITD in general.Indra has a vast experience in the aeronautical sector. Indra is a consolidated and certified aeronautical supplier accordingto aeronautical and international standards with capabil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'New Spin for Molecular Magnets'.

assistant: **Concept**

One of the next great challenges facing Europe is the development of new materials that reduce our dependence on critical metals such as rare earth elements (REEs). REEs have revolutionized both magnets and microelectronic industry, but the lack of economically exploitable deposits combined with geopolitical concerns have led to an impending resource problem. Molecular magnetic materials based on organic radicals represent one attractive alternative to REEs as the use of organic compounds would allow chemical processing rather than metallurgical. The challenge lies in developing radicals that are indefinitely stable under standard ambient conditions but still structurally tunable to attain the desired properties. This research project investigates two families of stable organic radicals and their metal complexes as new components for molecular magnetic materials. The radicals are based on the 1,2,4-triazinyl framework which, despite a long history and extreme stability, has only recently raised interest in materials oriented research. The potential of the investigated radicals will be exploited in two approaches. First, co-crystallization of the triazinyl radicals is studied as a novel design strategy to enhance intermolecular ferromagnetic interactions in organic radicals, and second, coordination of the radicals to paramagnetic metal centres is used as further means to control spin interactions through intramolecular spin coupling. The proposal combines the research ideas and synthetic skills of the experienced researcher with the knowledge and infrastructure of the supervisors and their hosting institutions, creating an interdisciplinary project that spans multiple fields from organic and organometallic synthesis to computational chemistry and condensed matter physic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CENTAUR - COPERNICUS ENHANCED TOOLS FOR ANTICIPATIVE RESPONSE TO CLIMATE CHANGE IN THE EMERGENCY AND SECURITY DOMAIN' (CENTAUR) targeting Horizon Europe.

assistant: **Abstract**

Within HORIZON-CL4-2021-SPACE-01-43 - Copernicus Security and Emergency Services evolution, the objective of CENTAUR is to respond to societal challenges deriving from Climate Change threats by developing and demonstrating new service components for the Copernicus Emergency Management Service (CEMS) and Copernicus Service in Support to EU External Action service (SEA), aiming to:1. Improve situational awareness and preparedness around climate change and its impact on complex emergencies and multi-dimensional (security) crises;2. Anticipate the occurrence and possible knock-on effects of crisis events, in particular those triggered by climatic extremes, thus contributing to resilience and effective adaptation.In the emergency domain, CENTAUR will address the flood-related threats to population, assets and infrastructures in urban areas. In the Security domain, CENTAUR will address water & food insecurity. The two work streams will be connected via a cross-cutting component focusing on exposure and vulnerability to climate change, as well as resilience and societal capacity for managing environmental risks and social conflict. Across work streams, indicators and models will be validated by different methods. CENTAUR will integrate data coming from multiple heterogeneous sources, with a specific focus on those generated by other Copernicus services, and, in particular, those of the Climate Change Service). It will combine these with meteorological data, socio-economic data, and data coming from new sensors (e.g. traditional and social media). Thus, it will enhance current capacities to produce composite risk indexes and to perform multi-criteria analyses in the emergency and security domains.


**Keywords:** Copernicus Emergency, Copernicus Security, Urban Flood, Food&Wate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spore probiotics: an alternative to antibiotics in animal husbandry' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The overuse of antibiotics in the farming industry has profound public health implications. Of most concern are the proliferation of drug-resistant bacteria and the transfer of these bacteria from farm animals to humans. This year Denmark has made the landmark decision of banning antimicrobials as growth promoters in pigs. This decision reinforces several key actions in the 5th framework in 'finding antibiotic alternatives' and 'reducing their use in animal husbandry'. One option is the use of robotics or CE agents. We have recently discovered that bacterial spores are effective CE agents and can suppress the colonisation of an E. coil pathogen in poultry. Spores are remarkably robust and could be mixed with animal feed. We have assembled a group of three spore researchers and two commercial partners, coordinated by a leading Agricultural Research facility. We will determine how spores work as CE agents/robotics and commercially exploit them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Phantom Possession. The New Authoritarian Personality and its Domains.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Authoritarian political forces are a growing global phenomenon. In critical theory, this is explained either through material factors, running the risk of economic reductionism, or through psychological traits, individualizing the matter in a problematic way. To date, no theoretical framework integrates the two dimensions in a consistent way, leading to deep rifts in political analysis.The proposed research programme introduces the term phantom possession in order to bridge between the material and the psychological level. The notion of phantom possession allows the reconstruction of authoritarianism as driven by property logic. Conceptualised as a domain requiring control and defence, the phantasmatic entitlement becomes a reference point for authoritarian mobilization. Consequently, the subject of authoritarianism can be characterized as a phantom owner.The full theory of the authoritarian personality as phantom owner consists of three components. The first is an account of the politics of phantom owners. As Hannah Arendt mentioned  in her analysis of modern mass-politics, authoritarianism is destructive in a way prefigured by early modern property discourse. I analyse destructiveness as the core characteristic of authoritarian politics. The second component investigates the psychology of phantom owners. To understand the psychological basis of authoritarianism, I link the Frankfurt School approach of authoritarian character formation with newer trends in feminist object-relations theory. On this basis, prejudices can be understood as defensive mechanisms, and defensiveness as the defining feature of authoritarian psyches. The third component implements my account. I show how the dual license to violence implied by property – the right to destroy and the right to aggr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Geometric and Harmonic Analysis with Interdisciplinary Applications' (GHAIA) targeting Horizon 2020.

assistant: **Abstract**

GHAIA will promote excellence through mobility to the world leader Universities in pure and applied mathematical research:  Princeton University, Mit, Yale, Johns Hopkins, the Universities of California, of Texas, of Houston, of Pittsburgh, the Washington University (St. Louis), and the Worchester Polytechnical Institute, the  Academia Sinica, the University of Buenos Aires have joined the consortium. European researchers will have the extraordinary opportunity to work in their exciting environment as well as receiving visiting researchers from south America. Moreover two selected enterprises have joined the consortium, allowing intersectorial mobility: Marposs and GMV, leaders in the strategic sectors of EU industry of precision equipments for automatic inspection, and of satellite navigation.Emerging technological problems call for the development of a new integrated framework of geometric and harmonic analysis, which unify in an original picture problems strongly influenced by symmetries and coming from different mathematical and technological fields. The exploitation of groups and supergroups invariances is one of the central goals of harmonic analysis, and nonlocal or nonlinear PDE in group setting present new and unexpected properties. Achievements in these directions are strictly related to a good geometric analysis of the ambient space. With these instruments we will be able to contribute to some of the biggest challenges of this century: data analysis and models of brain functionality. The final goal will be to obtain new geometrical instruments of machine vision, to be applied to develop new products for measurement of industrial processes and for satellite guidance.The international collaborations, through research and secondments, with the extraordinary sele