RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neuronal Activity: Targets for Stimulating Myelin Formation and Repair in the Brain' (2007-2013).

assistant: **Concept**

Neurological disorders associated with dysfunctional and damaged myelin represent a heavy economic and social burden within the EU. Therefore identifying novel targets for stimulating myelin formation and repair hold significant value. Neuronal activity influences the development of myelinating glia and the formation of myelin in the brain. However the physiological basis of these neuron-glial interactions are poorly described in the context of intact nervous tissues. This work will focus on receptors that are capable of integrating neuronal activity with oligodendrocyte function. Neuronal activity stimulates ionotropic glutamate receptors located on oligodendrocyte precursor cells (OPCs). However the function of these neuron-OPC synapses in the nervous system is unknown. Activation of these receptors regulates the migration and differentiation of oligodendrocyte precursor cells in vitro. By relaying information regarding axonal function these receptors are well positioned to translate changes in activity arising during development, and as a consequence of injury and disease, into signals capable of promoting the developmental programme required for myelination. Consequently these receptors represent valuable targets for stimulating neural repair in conditions of myelin disease and injury. These ideas will be tested by selectively disrupting glutamate receptor functions in OPCs with a series of novel genetically encoded tools. These tools will be deployed in slice cultures that permit the analysis of myelin formation and repair. The effect of these receptor manipulations will then be examined on axon-OPC interactions, OPC development, myelin formation, and myelin replacement. Illuminating mechanisms connecting axonal activity to myelin formation and recovery promises to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A Promising Treatment of WWOX Associated Neurological Disorders'.

assistant: **Concept**

A Promising Treatment of WWOX Associated Neurological DisordersWWOXAIDWWOX-related epileptic encephalopathy (WOREE) syndrome, also known as early infantile epileptic encephalopathy, 28 (EIEE28, OMIM: 616211), is a very severe epileptic encephalopathy characterized by absence of language development and acquisition of walking, early-onset drug-resistant seizures, ophthalmological involvement, and a very high likelihood of premature death. Above all, WWOXAID aims to set the basis for bringing into clinical development a treatment for WOREE syndrome affecting children in infancy. Although WOREE syndrome has very limited market prospects, since the number of known patients is low and no current active registry is available, this development is critical because there is no current treatment that could save children with WOREE. In addition to this highly humanitarian purpose, we are confident that this PoC achievement shall be also of importance for broadening the spectrum of applications of this treatment in other WWOX-related disorders. In this PoC, we will achieve several necessary steps including the generation, characterization and delivery of the vectors, securing IPRs, conducting a specific market assessment, targeting regulatory constraints, implementing a business development plan, consulting with professionals in the field and developing contacts with the industry, dedicated organizations and medical doctors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'GeometRic ANalysis of Dilute PlasmAs' in the context of a Horizon 2020 call.

assistant: **Objectives**

The ultimate goal of this Fellowship is to understand the long time behaviour of plasmas governed by the relativistic Vlasov-Maxwell system (RVM). The main difficulty is the hyperbolic nature of Maxwell's equations (the electromagnetic fields propagate at the speed of light): particles that travel close to the speed of light nearly interact with their own fields. It is not currently known whether particles can be accelerated to such speeds, and, if so, whether this necessarily leads to development of singularities. This is a major open problem.My expertise in the analysis of hyperbolic equations and in microlocal analysis, complemented by my host's expertise in kinetic theory will put us in a unique position to make progress on this problem. As an integral part of this Fellowship I will train in kinetic theory, and my host and I will share our mutual networks in Europe and around the world to help us study this major open problem.To this end, I have identified several workpackages with intermediate objectives to facilitate the progression:WP1: TOY MODEL. First I will analyse a toy model of RVM that preserves the hyperbolic nature, yet is simpler to handle.WP2: THE LINEARISED SYSTEM. I will then analyse the linearised RVM system using novel tools from microlocal analysis.WP3: PARTICLE TRAJECTORIES. Returning to the RVM system, I will use the previous results, together with further hyperbolic techniques (such as Strichartz estimates) to improve existing a priori estimates for particle trajectories.I also have robust career development and public outreach agendas, to complement the scientific aspects of this proposal. Combined, all these elements will establish me as a prominent research leader upon my return to the Beijing Institute of Technology, with extensive links thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The chances of the second generation in families of ethnic entrepreneurs: intergenerational and gender aspects of quality of life processes' (ETHNOGENERATION).

assistant: **Innovation**

The proposal addresses the quality of life in ethnic business and the chances of the next generation to accumulate educational and cultural resources in order to integrate successfully into the society. Biographical interviews with parents and children in ethnic business will explore the quality of life of the parents' generation and its relationship to the children's process of accumulating educational and cultural resources, especially taking into account the women's situation in ethnic businesses. Statistical and secondary data analysis will frame the selection of the sample and the interview analysis. Expected is knowledge on family strategies that prevent or support the accumulation of resources by the children. On the basis of these results suggestions will be formulated for policy measures aiming at minimizing the inheritance of inequality in the next generation, maintaining at the same time, the benefits of ethnic business which makes social and economic integration a possibility for migrants threatened by exclusion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optical Ultra-Sensor' (OPUS).

assistant: **Concept**

This project aims at pushing the limits of optical sensing on a microchip by orders of magnitude, thereby allowing for ultra-high sensitivity in optical detection and enabling first-time-ever demonstrations of several optical sensing principles on a microchip. My idea is based upon our distributed-feedback lasers in rare-earth-ion-doped aluminum oxide waveguides on a silicon chip with ultra-narrow linewidths of 1 kHz, corresponding to Q-factors exceeding 10^11, intra-cavity laser intensities of several watts over a waveguide cross-section of 2 micrometer, and light interaction lengths reaching 20 km. Optical read-out of the laser frequency and linewidth is achieved by frequency down-conversion via detection of the GHz beat signal of two such lasers positioned in the same waveguide or in parallel waveguides on the same microchip.The sensitivity of optical detection is related to the laser linewidth, interaction length, and transverse mode overlap with the measurand; its potential of optically exciting ions or molecules and its optical trapping force are related to the laser intensity. By applying novel concepts, we will decrease the laser linewidth to 1 Hz (Q-factor > 10^14), thereby also significantly increasing the intra-cavity intensity and light interaction length, simplify the read-out by reducing the line-width separation between two lasers to the MHz regime, and increase the mode interaction with the environment by either increasing its evanescent field or perpendicularly intersecting a nanofluidic channel with the optical waveguide, thereby allowing for unprecedented sensitivity of optical detection on a microchip. We will exploit this dual-wavelength distributed-feedback laser sensor for the first-ever demonstrations of intra-laser-cavity (ILC) optical trapping
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European science communication events extension creation of a euroean science communication events network with database, analysis & improvement recommendations & for existing and new organisations' (1998-2002).

assistant: **Innovation**

Science Communication Events (SCE) are special and very efficient means to bridge the gap between science in its European dimension and the general public. 38 organizations of 23 European countries formed EUSCEA - European Science Events Association - in December 2001. They detected the urgent need to harmonize SCE organizations in all of Europe for efficient, professional and scientifically based enhancement of their activities.The structured approach to achieve this goal consists of(1) the creation of a general database of all SCE activities available to the public in print and in the Internet, further(2) a structured analysis of the strengths and weaknesses of all SCE organizations resulting in a tool-box with general and individual recommendations, which(3) are implemented under close supervision for the future development of the European Science Communication Events. A further result is(4) the professional assistance for new SCE organizations in other regions or (associated) countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CellCount – a revolutionary testing platform to solve current problems with microbiological contamination in water and food industries' (CellCount).

assistant: **Concept**

Food- and water-borne illnesses are common and preventable public health issues. Hundreds of millions of samples are tested each year to detect harmful bacteria in drinking and environmental water, food and beverages. Pathogens such as Legionella, Pseudomonas, Giardia/Cryptosporidium, Salmonella, Campylobacter and E. coli (O157:H7), cause disease and lead to enormous economic damage.Events such as, the 2013 Legionella outbreak in Warstein, Germany, with over 185 cases of disease, or the Danish Listeria outbreak of summer 2014, with 12 reported deaths and the shutting down of the meat producing company, painfully demonstrated the limitations of current testing methodologies. Long testing times, and insufficient analytical quality in results lead to unsuccessful countermeasures, spread of the disease, and waste of energy and biocides, and financial loss for the organisations involved.CellCount is a novel testing technology that delivers fully quantitative test results at an unmatched speed. CellCount revolutionizes the pathogen detection market by combining various new technologies, already well-established in the academic environment, and applying them to industrial applications. Due to its novel sample preparation and pathogen detection technology, CellCount provides a quantitative pathogen detection result within one hour, compared to days and weeks for other methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Wind as main propulsion by ORCELLE' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In the ORCELLE project we will develop and demonstrate a solution for wind as main propulsion. With wind as main propulsion we mean an energy efficiency gain of more than 50% as an average saving in full year operation. Under ideal sailing conditions the energy efficiency gains are close to 100%. Engines are only used in situations with insufficient wind resources, for manoeuvring and increased ship safety.ORCELLE builds on several large previous projects where we have worked to build simulation tools, wing systems and initial designs of a prototype vessel. In this project we combine improvements to the simulation framework and wing systems by building two physical demonstrators: A 1-wing retrofit (targeting 10% efficiency gains) and a multi-wing newbuilt demonstrator (targeting +50% efficiency gains overall). The demonstrators are RoRo (PCTC) vessels that will operate in a trans-Atlantic route transporting cars and other cargo. We have an extensive set of sensor systems onboard the ships which will allow them to function as research vessels to validate & improve designs, simulation tools and prototype designs of ship & wing systems. A tailored, dynamic weather routing software and service will be developed to optimize sailing performance.The project is a strong opportunity to combine the investments needed to get full scale demonstration and data capture with advanced models and tools for  wing propulsion vessels. The project coordinator is Wallenius Wilhelmsen, a world leading RoRo logistics operator with some 130 RoRo vessels in global service. Beyond the demonstrator, we use the models and tools to develop advanced conceptual designs and operational plans for multiple vessel types: Tanker/bulk carriers, shortsea vessels, containerships, cruise and ferries. This form
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Development of a complete integrated SNP analysis system'.

assistant: **Objectives**

The requirement to screen for known SNPs (single nucleotide polymorphisms) has become one of the key challenges to be addressed to enable the exploitation of the human genome sequence, where approximately 3 million SNPs are responsible for all of the variation within the human population. Several methods and technologies are currently available for detection of SNPs, but no single platform exists which can deliver 100% accuracy, in a low cost, versatile, and easy-to-use integrated system.The proposed research will focus on the development of integrated SNP detection platforms to include modules for DNA extraction and purification from biological samples, DNA amplification, DNA characterisation (including SNP detection), signal transduction, interpretation and data analysis. Integration of the modules on a single platform will include a transport mechanism based on electrowetting actuation (EWOD).Two alternatives SNP detection platforms will be developed based on optical and magnetic sensing respectively. The whole system will be packaged as a single automated functional system with a simplified GUI interface, based on specifications recommended by potential end-users within the consortium. This systems development will focus on delivering a product customised for low to medium throughput, low cost, point-of-care applications, with emphasis on providing very rapid and accurate results.Within the project, the systems will be benchmarked for screening of SNPs in the CFTR gene that are associated with cystic fibrosis. CF patient samples will be used to verify the accuracy and reproducibility of the system in a clinical diagnostics laboratory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'TRANSACT' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

To transfer proven and successful university based start-up support schemes to innovative actions in Newly Associated Countries (NACs).Description of the work:Innovation and start-up creation in Newly Associated Countries is restricted due to the paucity of support services and the lack of an established infrastructure. This means that there is less co-ordination and co-operation between innovators within NACs and therefore less opportunity to share best practices.The project aims to transfer existing university based start-up support schemes, having proven their excellence in regional, national and European evaluations, to NACs. Transact will have a strengthening impact on the economic potential and competitiveness amongst the NAC regions, with an aim to improving conditions for the creation and development of new companies.Initially, analysis by independent experts will determine separately the effectiveness of each support scheme and the special needs / preconditions of the NAC partners. EU and NAC partners, aided by the decision-makers of partner NACs, will then evaluate the transferability of these support models/approaches/instruments to the previously identified special conditions of the NACs. Once the analysis has been completed an assessment will be made on the compatibility between EU support schemes and NAC start-up ventures.Open Space ConferencesFor effective decisions to be made, participants will attend Open Space Conferences (OSCs) which will act as collaborative planning instruments. All the relevant parties will come together in one place, making planning, sharing of knowledge and selection of partners and tools much easier. The initial OSC will act as an introductory forum in which all participants will convene to discuss the conclusions of the evaluat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Technological Choices of Coastal populations : a functional perspective through the use-wear study of knapped lithic tools during the Late Mesolithic (6300-4500 cal BC) in south Norway.' (TeCh-Coast) under Horizon Europe.

assistant: **Objectives**

TeCh-Coast aims to understand how past populations have used tools and what technological choices they have made to deal with the coastal environment. On the southern Norway seashore, the Late Mesolithic (6300-4500 cal BC) sites constitute a unique knowledge repository of coastal hunter-gatherer populations, in which stone-knapped tools are the most frequent artifacts. However, very little is known about the use of these to exploit coastal resources. How and for what were these tools used? How does their use reflect socially transmitted technological knowledge to exploit coastal resources? Through an innovative and interdisciplinary techno-functional approach, TeCh-Coast aims to bring new functional data on the use of lithic tools to further understand the technological choices of coastal populations. Analyses of the plastic deformations on the surface of the tools due to their use (i.e. use-wears) will be performed on three preselected lithic assemblages. In addition, an experimental analytical program will be set to identify quantifiable wear attributes in lithic tools resulting from the exploitation of marine animal resources by means of confocal scanning microscopy. Finally, by combining observations with a dynamic technological approach and landscape archaeology, the project will aim to identify the technological choices of the coastal groups. More widely, the present project will provide a broader perspective on the Atlantic European seashore, allowing cross-regional comparisons with other coastal groups. The TeCh-Coast project results will have an important impact on the research of the coastal Stone Age hunter-gatherer populations, as well as bring new methodological perspectives to use-wear studies. The results will be disseminated by open-access publications a