RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Building Information aGGregation, harmonization and analytics platform' (BIGG).

assistant: **Innovation**

EU countries have drawn up strategies reflected in their National Energy Efficiency Action Plans that include provision of an overview of the country's national building stock, identification of key policies that the country intends to use to stimulate renovations and provision of an estimate of the expected energy savings that will result from renovations. Despite the increase in the use of energy and the evident environmental benefits of having more share of renewable energy sources (RES) in buildings, the adoption of both energy efficiency measures and RES is highly influenced by its cost and the impact on occupants’ comfort. The real implementation of actions to reduce energy consumption in buildings is confronted with the complexity of managing their internal energy systems, the overall target of cost savings and the respect of the levels of comfort expected by the buildings occupants.The BIGG project aims at demonstrating the application of big data technologies and data analytic techniques for the complete buildings life-cycle of more than 4000 buildings in 6 large-scale pilot test-beds, achieved by: 1) The Open Source BIGG Data Reference Architecture 4 Buildings for collection/funneling, processing and exchanging data from different sources (smart-meters, sensors, BMS, existing data sets); 2) An interoperable buildings data specification, BIGG Standard Data Model 4 Buildings, based on the combination of elements from existing frameworks and EC directives, such as SAREF, INSPIRE, BIM, EPCHub that will be enhanced to reach full interoperability of building data; 3) An extensible, open, cloud-based BIGG Data Analytics Toolbox of service modules for batch and real-time analytics that supports a wide range of services, new business models and support reliable and eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Investigating the role of cilia proteins in dividing cells: implications in kidney cyst formation and ciliopathies' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cilia proteins, including proteins of the intraflagellar transport machinery (IFT) were initially identified for their link to polycystic kidney disease but were also described as potential tumor suppressor. This suggests that common cellular pathways, which have yet to be characterized, might contribute to both benign cyst formation and cancer. Cystogenesis has long been associated exclusively with cilia dysfunction. However, our recent finding of IFT88 functioning in spindle orientation during mitosis suggests that cilia dysfunctions might explain only part of the mechanistic underpinnings of ciliopathies. Indeed, this finding and the fact that several proteins of the IFT machinery localize to spindle poles during mitosis or to the midbody during cytokinesis suggests that cilia proteins, well characterized so far for their role in cilia, might have cilia-independent functions in dividing cells that have yet to be explored.The overall objective of the project is to investigate the roles of cilia proteins in dividing cells and thus to tackle form a different angle the longstanding question of their role in pathologies. First (AIM1), we will identify a list of cilia proteins involved in cell division using High content screening in cultured cells. Then, we will characterize the role of a subset of IFT proteins involved in dividing cells at the cellular (AIM1) and molecular (AIM2) levels. Then (AIM4), we will address in vivo the physiological relevance of mitotic dysfunctions associated with cilia protein depletion in kidney cyst formation using zebrafish.Our general strategy will combine cell biological and biochemical approaches in cultured cells with the use of zebrafish (Danio rerio) to study in vivo cellular processes associated with pathologies. Overall, this projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'FoldAmeRs : a new family of G-QUADruplex ligands' (FAR-QUAD).

assistant: **Innovation**

This proposal focuses on the formation of complex between DNA G-quadruplexes and a new family of synthetic ligands, which might be relevant for cancer therapy. The enzymatic acitivity of telomerase is critical to the immortality of most human cancer cell lines. However, telomeric DNA may fold into guanine quadruplex structures which are not competent substrates for telomerase. Therefore, the use of small molecule ligands to induce quadruplex stabilisation in telomeric DNA has potential as an anti-cancer strategy. A European collaboration recently engaged between I. Huc (Bordeaux, France) and S. Balasubramanian (Cambridge, UK) groups already led to the identification of a very promising compound, with exceptionnal potential for stabilising human G-quadruplex telomer. In addition a three dimensionnal helical compound (foldamer) has shown interesting activity. This project, involving chemistry, biology and biophysic, aims i) to systematically design and develop new analogues of this promising candidate, based on aromatic delta-peptide chemistry; ii) to evaluate their G-quadruplex binding affinity in telomere and others systems; iii) to establish structure-activity relationships; iv) to determine the key elements necessary for specific G-quadruplex recognition by solving the structure of the first ligand complexed with G-quadruplex. This original interdisciplinary proposal involves two international leading groups in their respective field, to develop new tools and knowledge on the growing interest on natural G-quadruplexes as new target for anti-cancer strategy. The applicant will have a crucial role in the development of this collaboration and will become an active and efficient third partner, when returning back to China at the end of the fellowship.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Stalin, Hitler, Roosevelt and Churchill: Communication between Political Leaders and Their Audiences in Interwar Europe and United States' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The picture of the 20th century leaderships in social sciences and humanities is still dominated by  a number of uncritically accepted postulates such as (1) ascription of special manipulative) properties to Nazi, Soviet or Fascist language; (2) fixation on vocabulary only(G.Orwell's  ‘newspeak’) and (3) belief in suggestive power of classical rhetoric projected onto semi-literate masses.These theses find little empirical support in recent scholarship. It turns out that (1) manipulation is typical for political communication even in modern democracies, (2) fuzzy logic has proved more useful in swaying public opinions than ‘wrong’ vocabulary, and (3) the image of scarcely educated people enjoying Ciceronian rhetoric of tyrants does not pass serious scrutiny: Hitler's speeches in German regions were negatively related to his popularity up to 1933, and influenced positively only those who knew and supported his views.Still, few attempts at isolating informational flows between chief executives and their constituencies have been made, so we are still in the dark about the knowledge gained by an average listener of Roosevelt's fireside chat or a participant of a Nazi rally in Nuremberg. The first samples show that preexisting knowledge about the speaker, communicative setting, voice or gestures could play a crucial role, whereas the verbal content would mostly fill the gaps. To prove or disprove this hypothesis, a set of linguistic and anthropological methods is applied to the model of direct communication constructed by pairing messages (political speeches of Hitler, Stalin, Roosevelt and Churchill) with feedbacks (direct responses to those speeches in private letters).The importance of knowing how communication between political leaders and their audiences actually worked
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Operation of a Novel Sofc-battery Integrated hybrid for Telecommunication Energy systems'.

assistant: **Concept**

SOFCs are good energy sources to supply reliable power at steady state. Due to their slow internal electrochemical and thermodynamic characteristics, they cannot respond to electrical load transients as quickly as desired. During peak demand a battery can provide power in addition to the fuel cell, whereas the fuel cell can recharge the battery during low demand periods. The key advantage of this system architecture is that the fuel cell is operated without major load variations close to constant load resulting in longer lifetime and thus reducing total costs of operation.The realization of a hybrid system, capable of connecting production and storage devices on the one hand, and of managing and controlling the energy and its exchange with the  power grid on the other hand, represents the synergy of some innovative technologies, but already commercially available. The overall objective of ONSITE is the construction and operation of a containerized system, based on SOFC/ZEBRA battery hybridisation, that generates more than 20 kW at high efficiency and economically competitive costs. High Temperature ZEBRA batteries (NaNiCl) are intrinsically maintenance free, show long life and are fully recyclable. The choice of this kind of technology aims at exchanging thermal energy between the two devices, in order to enhance the total efficiency of the final system, as well. The natural gas (optionally LPG) operated SOFC and the ZEBRA battery will be thermally integrated. Both will provide power for TLC energy stations. Basic research will be pursued on SOFC stacks to reach FCH JU targets in terms of efficiency, duration and costs. On top of these activities, detailed analyses of final proof-of-concept life cycle cost and total cost of ownership are foreseen. The thermal energy (wa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Aflp analysis of the aspergillus section flavi complex' (1998-2002).

assistant: **Innovation**

The proposed project will develop AFLP techniques specific to section Flail species, which will enable rapid strain identification in a single test. The high level of strain discrimination afforded by the AFLP analysis will allow clear distinction between aflatoxigenic and non-aflatoxigenic strains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Trace element behaviour in wet flue gas desulphurisation units' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Within the recent years the use of bio-waste materials (sewage sludge, waste wood, refuse derived fuel) in dedicated plants (FBC) or as an additional fuel to coal for co-combustion (PF) has been proved to contribute besides CO_2 reduction aspects to a decrease in fuel costs and therefore in energy costs. In addition to possible operational problems major obstacles for an increased use of the energy content of these fuels for heat and power production are the risk of compromising the quality and utilisation of by-products as well as the apprehension of an increase of hazardous air pollutants (HAPs ) emissions, whereas toxic metals and fine particles having a high relevance. Wet FGD or scrubber systems are currently installed on most of the coal-fired utility boilers and in many waste incineration systems in Germany. Although their primary function is to remove SO_2 emissions from flue gas, wet flue gas cleaning systems can also be effective in removing trace elements from boiler flue gases. The main objective of the proposed work is to study the behaviour of trace elements during the use of sewage sludge, waste wood and refuse derived fuels in dedicated plants (FBC) or as an additional fuel to coal for combustion Besides detailed fuel analysis and characterisation the major part of the experimental investigations will be carried out on an available lab-scale flue gas cleaning system The work will consist of the following tasks:1 ) Determination of the inlet and outlet gas and particulate concentration, characterisation of trace elements by determination of their content as well as their speciation2) Investigation and analysis of scrubber chemistry regarding trace element removal3) By-product quality, regarding disposal or utilisation4) Comparison of results obtained duri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evolution and mechanisms of thermal performance – answers through artificial selection in zebrafish' (CLIMEVOLVE) targeting Horizon 2020.

assistant: **Abstract**

Abstract Climate change is warming waters globally. Ectothermic animals, such as fish, have the same body temperature as the surrounding water and are therefore thought to be particularly sensitive to warming. To predict climate change impacts on fish populations, we must first know how fish are affected and how rapidly evolution may help mitigate some of those impacts.   Some of the most central questions regarding thermal acclimation and adaptation of ectothermic animals remain unresolved: 1. Which mechanisms limit upper thermal tolerance?  2. How rapid is evolution of thermal performance? 3. Which physiological mechanisms limit thermal performance? 4. Which genetic changes are most important for climate change adaptation?  5. Do laboratory experiments predict thermal adaptation in the wild?   By addressing these important questions, this project will substantially move the field of thermal biology forward. We will gain knowledge needed to understand and predict climate change impacts, insights that may help focusing conservation efforts. The proposed project will address these great challenges by using two artificial selection experiments on wild zebrafish (Danio rerio). The first selection experiment on upper acute thermal tolerance has recently been completed, and the adapted zebrafish lines will be used in the current proposal for physiological and genetic analyses. The second and larger selection experiment on thermal performance will be conducted during the first three years of the proposed project, and those adapted zebrafish lines will be used to identify the physiological and genetic changes that adaptation required. Additionally, unique natural warm-adapted stickleback (Gasterosteus aculeatus) populations from geothermally heated lakes on Iceland will be use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Multi-Material Design using 3D Printing'.

assistant: **Concept**

Additive manufacturing (AM) has the economic potential to complement conventional manufacturing processes, especially in the production of complex, multi-material (MM) components. To exploit the full benefits of optimized lightweight structures, it is usually required to use multi-materials with different physical properties. Still, multi-material combinations from conventional processes are not transferable to AM, due to residual stresses, cracks or thermal expansion rates of the different materials. Furthermore, geometric shape and position tolerances, as well as recycling strategies for powder waste, post-processed waste and the component itself are not yet defined. Based on the 3D printing processes PBF-LB and DED, this project aims at the concurrent engineering of designing processable multi-material optimized alloys, development of design concepts for multi-material structures with specific simulations for load cases and topology optimizations, and an extensive process adaption. Alloy and process development will be aided by advanced integrated computational material engineering approaches that combine thermodynamics, microstructure, and process simulations through machine-/active learning, resulting in shorter material development cycles. For bulk and powder materials, recycling of multi-material components via innovative concepts will promote the sustainability of multi-material additive manufacturing. This adaption will lead to increased process reliability and speed, enabling the dissemination of MM manufacturing in AM for the entire industry.The consortium brings a wide range of international expertise to the table, from materials research and digitization to the manufacture of multi-material components. It consists of startups, research institutions and mark
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Experimental UpdateLess Evolutive Routing'.

assistant: **Objectives**

The main objective of the EULER exploratory research project is to investigate new routing paradigms so as to design, develop, and validate experimentally a distributed and dynamic routing scheme suitable for the future Internet and its evolution. The resulting routing scheme(s) is/are intended to address the fundamental limits of current stretch-1 shortest-path routing in terms of routing table scalability but also topology and policy dynamics (perform efficiently under dynamic network conditions). Therefore, this project will investigate trade-offs between routing table size (to enhance scalability), routing scheme stretch (to ensure routing quality) and communication cost (to efficiently and timely react to various failures). The driving idea of this research project is to make use of the structural and statistical properties of the Internet topology (some of which are hidden) as well as the stability and convergence properties of the Internet policy in order to specialize the design of a distributed routing scheme known to perform efficiently under dynamic network and policy conditions when these properties are met. The project will develop new models and tools to exhaustively analyse the Internet topology, to accurately and reliably measure its properties, and to precisely characterize its evolution. These models, that better reflect the network and its policy dynamics, will be used to derive useful properties and metrics for the routing schemes and provide relevant experimental scenarios. The project will develop appropriate tools to evaluate the performance of the proposed routing schemes on large-scale topologies (order of 10k nodes). Prototype of the routing protocols as well as their functional validation and performance benchmarking on the iLAB experimental f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Total Crystallography: Structure and dynamics of polycrystals' (TOTALCRYST) targeting Sixth Framework.

assistant: **Abstract**

The aim of this project is to develop a method for characterization of the structure and dynamics of polycrystals on length scales from the atomic-level to that of the sample. The method, TotalCryst, determines the atomic arrangement within each grain as w ell as the 3D position and morphology of the grains.The structure of each grain can be solved and refined with accuracy presently obtainable only by studies of large single crystals. The method applies to inorganic structures as well as macromolecules and probes grains on all length scales from 100 nm to 1 mm. In this project it will be applied to studies within:Chemistry: TotalCryst will enable the identification and structural quantification of numerous complex or dilute structures which cannot be characterized by present methods. The method may find a widespread use in the pharmaceutical industry.Firstly, it accelerates the process of structure determination, a bottleneck in the process of registration of a new drug. Secondly, it enables characterization of drug content, polymorphism and homogeneity in tablets. Structural biology: Attempting to solve ever-larger structures, crystal quality and radiation sensitivity are major concerns. TotalCryst is a novel strategy for overcoming these issues.Time-resolved studies: TotalCryst offers a number of attractive and unique properties making it highly suitable for time-resolved studies. This includes conventional dynamic studies with time constants of the order of seconds as well as studies in the nano- to femt o-second regime based on stroboscopic methods involving a laser pump / X-ray probe scheme.An example is the possibility to, for the first time, study photo-sensitive materials, e.g. photoactive switches for photovoltaic devices and pigments. The consortium comprises