RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '3D printed COLLagen type I-Hydroxyapatite prostheses for the middle EAR', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Conductive hearing loss is a pathology that affects about 15% of the worldwide population and more than 40% of the elderly. So far, passive implants, made of titanium and hydroxyapatite, are the preferred solution to restore the middle ear function. Unfortunately, a significant percentage of extrusion still occurs (up to 40% in the long term) due to reduced biocompatibility. The applicant (i.e. experienced researcher, ER) studied ear micro-prosthetics during his PhD and aims at developing a new generation of 3D printed bulk micro-prostheses for the middle ear made of collagen type 1 and hydroxyapatite, namely, the native components of the ear bones, to improve the quality of life the European citizens, who are highly prone to conductive deafness due to their longevity. To achieve this ambitious goal, thus maximising the acoustic behaviour of the composite material from its basic unit, the ER needs to learn multiscale design (i.e. from the atomic- to the macro-scale), which will be addressed during the outgoing phase at MIT. Therefore, a dedicated study will be carried out on 3D printing techniques in order to fabricate a set of new prototypes, which will be challenging due to the small size versus high performance of the ossicular prostheses. The ER will investigate and characterize the newly designed prostheses from a topological and acousto-mechanical standpoint at University of Antwerp (2-month secondment) and through a dedicated bioreactor, designed and manufactured on purpose at Scuola Superiore Sant’Anna (Beneficiary) to be used for a biologic assessment at University of Pisa (4-month secondment). The multidisciplinary approach involving acoustics, materials science, engineering, biology and otology will enhance the development of innovative clinically oriented pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Highly Efficient Photoemitters for Light-Emitting Diodes Based on Intramolecular Rotation' (ROLEDS) targeting Horizon 2020.

assistant: **Abstract**

We have discovered a new class of photo- and electroluminescent complexes which are suitable for incorporation into organic light emitting diodes (OLEDs) and which give up to 100% internal quantum yield. The new compounds are particularly suitable for the fabrication of OLEDs via cheap solution-processing techniques and have so far reached 27% external quantum efficiency, a record for any solution-processed device. The new complexes have a linear, rotationally flexible structure, and it is this rotation that allows 100% of the excitation energy to be harvested, by a new emission mechanism (“rotationally accessed spin-state inversion”, RASI). OLEDs are widely used as flat-screen displays (TVs, smartphones), a multi-billion dollar market worldwide. The industry-leading emitters are based on complexes of iridium, one of the rarest elements on earth. Our emitters are compounds of copper, silver and gold, suitable as “slot-in” replacements of iridium. IPR is protected by two UK and one PCT World patent applications. The key discovery is that in certain types of coordination complexes based on carbene ligands the excited singlet state sinks below the excited triplet state during molecular rotation. To our knowledge this is the first realization of ""spin-state inverted"" materials, until now discussed only as a theoretical concept. The result is efficient, very fast light harvesting with highly desirable short (sub-microsecond) excitation lifetimes, leading to high display brightness (in prototypes 20 times brighter than a HD TV screen), with potential lighting applications.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'European Models for Purchasing Strategies : Development of computer models to determine purchasing strategies and priorities for maternity care services and health care services for people with stroke and coronary heart disease'.

assistant: **Objectives**

. To develop and assess a tool based on the concept of clinical effectiveness and efficiency which can assist purchasers of health care in decicion-making across European countries. The health care services involved are maternity care and care for people with stroke. To assess the feasibility of applying a disease-specific European decision framework to develop policy models as tools for analysing purchasing decisions at strategic level . To assess the experiences of planning officers who as potential users have been instructed in the use of the models to analyse purchasing decisions, and to establish the extent to which such models can assist and influence decision making, and judge whether the focus on clinical and administrative decisions is adequate and whether such models might have other beneficial usages - for example in a provider setting, or as part of a more general cost-effectiveness assessment.Many European countries have adopted a structure for their health care where the role of purchasers is separated from the providing function. Providers aim to deliver services that are of a high quality and low cost. Purchasers want to maximise the health gain from the resources available, subject to objectives of a fair and equitable access to health care. Other countries have less clear separation, but the purchasing function also exists in countries without separation of purchasers and providers. To fulfil their purchasing role, purchasers need to assess the population's need for services in order to determine purchasing strategies and priorities for service provision across different client/patient groups, disease areas, promotion, prevention and therapy. Purchasers should also decide which services should be provided for different patient groups and which services
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Programmable forwarding planes for Netxt generation Routers' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

As the IP networking industry matures, we experience a paradigm shift in the implementation of the IP routers. The new generation of applications for IP networks requires considerably shorter product development cycles, due to the renewed interest on extensibility and short turnaround times for the introduction of new products.This has led to the use of off-the-self components in router design. An increasing amount of commercial routers implement their control plane using commodity motherboard designs and processors that are used in personal computers along with modified commodity operating systems like Linux and the various free versions of BSDUnix.Thus, we believe than in the near future routers should and eventually will be built with commodity controller hardware, will use third party Network Processors for their forwarding path processing and open software for the operating system and routing protocols. Among the multiple research issues involved in the design of such a router we focus on the programmability issues.The use of programmable forwarding plane components results in a hierarchy of processing elements within the router At the top level of the hierarchy we have the general-purpose processor implementing the control plane while at the bottom of the hierarch y we have the Network Processor.The existence of the semultiple levels where operations can be implemented, opens up many possibilities for re-thinking the conventional wisdom on how to implement networking services and creates a variety of research issues.We plan to address the problem at two levels:- control plane, that runs at the control processor and has access to more resources but is far from the data flow and,- forwarding plane, which runs in specialized programmable hardware, and has less resour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Late Eocene climatic transition from greenhouse to icehouse conditions in the Neo-Tethys' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The middle Eocene to early Oligocene period represents the most important transition in Earth’s climate: from greenhouse conditions to the icehouse conditions of the present day. This global transition was preceded by long-term cooling with superposed short-term variations in various marine proxies, which indicate instability in the paleoceanographic state prior to the key climatic transition. We propose to test the hypothesis that global variations in climatic conditions were synchronous with large variations in circulation in the Neo-Tethys Ocean. Tectonic closure of the gateway between the Arabian and Eurasian plates represents a threshold that caused late Eocene paleoceanographic variations in the Neo-Tethys and in global ocean circulation. The premise of this proposal is that new paleomagnetic and environmental studies of Eocene sequences from the Tethys sector and Indian Ocean drill cores can provide important insights about the timing and nature of paleoclimatic events and sedimentary processes that affected the Eocene oceans. We will develop new high-resolution magnetostratigraphies from each proposed section to determine the timing of the bio-magnetic and climatic events. Sites in the Indian Ocean and sections in Italy, Egypt and Turkey are the best candidates. We propose a multidisciplinary study that involves detailed bio-magnetostratigraphy, environmental magnetism and cyclostratigraphic astronomical calibration. Paleobiological abundances, isotopic analyses and geochemistry will then be used to develop an integrated view of paleoceanographic events in this key interval of geological time. The quantitative dataset to be obtained will enable us to test the hypothesis that paleoceanographic variations in the Neo-Tethys were related to global Eocene climatic ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessment of human Dermal exposure to microPlastics additive chemicals and the risk arising from such exposure using innovative 3D-human skin equivalents' in the context of a Horizon 2020 call.

assistant: **Objectives**

Dermplast is a multidisciplinary project that combines advanced environmental analytical chemistry with innovative 3D-human skin equivalent models (3D-HSE) to study the dermal absorption of toxic plastic additives (e.g. plasticizers and flame retardants) upon skin contact with microplastics (MPs) and assess the risk arising from such exposure.Recent studies have revealed direct human exposure to MPs externally and internally, confirmed by detection of MPs in human stool. However, very little is known on the extent of human exposure to MPs via different pathways and the risk it poses to human health. While there is little evidence of adverse effects associated directly with exposure to pristine MPs, there is major concern over potential toxicity from released plastic additives (e.g. plasticizers and flame retardants), many of which have been associated with serious adverse effects including cancer. The main hypothesis that Dermplast tests is that MP additive chemicals can leach out into sweat and be absorbed through human skin; thus frequent contact with MPs can lead to significant body burdens of hazardous chemicals, with consequent adverse health impacts. This will be achieved using innovative 3D-HSE cultures as sustainable, efficient alternatives to animal/human tissues. The results will be applied to develop an advanced pharmacokinetic exposure model to estimate human uptake of toxic chemicals from dermal contact with MPs and assess the risk against current exposure guidelines and toxic endpoints for these chemicals.With current research focused mainly on isolation and characterisation of MPs in different matrices (e.g. food, water and air), DermPlast will make substantial advances to the state-of-knowledge by providing novel insight into risk assessment of MPs expos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Turbine bulbe mini-hydro a entrainement direct (DIRECT DRIVE MINI BULB-TYPE HYDRAULIC UNIT)' (1998-2002).

assistant: **Concept**

The project aims at developing a bulb-type hydraulic unit in the power range of 200 kW-2000 kW, water-lubricated, without speed increaser, controlled by electric servomotors. The direct drive of the AC generator needs the development of a low speed electric machine, which will decrease the volume of the unit and its noise. The water bearings and the suppression of the speed increaser lead to eliminate pollution of rivers by lubricants. The use of electric actuators leads to suppress the hydraulic oil. This bulb-type unit, smaller and more efficient, will be as reliable as existing ones and less expensive (-10% investment, O,O5E/kWh). It would be installed for stand-alone applications presenting good water supply, but could also be connected to a grid. It will make it possible to equip in good economic and environmental conditions the numerous sites available in Eastern Europe and in the world, and make an important contribution to increase the share of renewable in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identifying new anti-cancer drugs by computational multi-target approaches targeting the Gquadruplex DNA' (G4-mtQSAR) under Horizon 2020.

assistant: **Objectives**

The goal of the proposed research is to develop computational methodology which can screen out small ligand molecules having potential to selectively target G-quadruplex (G4) DNA which are associated with cancer pathology. Multiple oncogenes and telomerase activity are deregulated in various types of cancers. Ligand induced stabilization of G4s associated with the oncogenes (c-myc, c-kit, k-ras, etc.) and stabilization of telomeric G4s are efficient ways in targeted cancer therapy. Here, we intend to develop multi-target QSAR models that can aid in finding potential multi-target directed ligands (MTDLs) that can stabilize multiple G4s from different oncogenes simultaneously. It is the first computational study for identifying MTDLs against multiple G4s in Cancer treatment. Different multi-target QSAR approaches will be explored including ‘multiple regression and classification’ QSAR models, multi-target QSAR using Box-Jenkins moving average approach and multi-target QSAR using Perturbation approach. Several advanced machine learning techniques will be employed. A state-of-the-art software tool will be developed where all the successful multi-target QSAR models and in-house ADMET models will be incorporated as a knowledgebase. Notably, desirability-based multi-objective optimization approach will be used for identifying drug-like molecules. The software along with in-house KNIME workflows will then be used to screen potential MTDLs against multiple G4s. The selectivity and binding characteristics of the screened MTDLs towards G4s over duplex DNA will be analysed by performing molecular docking and molecular dynamics studies. The binding capacity of the screened MTDLs with intended G4s over duplex DNAs will then be confirmed using experiments such as isothermal fluorescen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Conformational Control in Designed Biomimetic Metallofoldamers: Towards  Functional Materials'.

assistant: **Innovation**

The established relationship between biopolymers structure and function has led to the design of “Foldamers” – synthetic oligomers that can fold into well-defined three-dimensional conformations stable in solution. Substantial progress has been made in establishing foldamers that emulate protein secondary and tertiary structures. Further advancement of foldamers requires design strategies that will enable their use as superior materials with unique functions. Metal ions are key cofactors in both the structure and function of proteins and essentially Nature’s choice for sophisticated tasks such as folding, catalysis, and recognition. Thus, the goal of this proposal is to generate metal-binding foldamers and investigate (i) whether metal binding can induce folding of biomimetic oligomers and stabilize 3D conformations, (ii) whether the interactions with foldamers can mediate the geometrical and chiral properties of the metal complexes formed, and (iii) their use as enantioselective catalysts and chiral sensors. We study the class peptidomimetic foldamers called “peptoids” – N-substituted glycine oligomers. Their facile and efficient synthesis on solid phase support, which employs primary amines, enables the incorporation of various functional groups at specified N-positions along their spine. We will design and synthesize a diverse range of peptoid sequences, with different degrees of conformational order, incorporating at least one metal chelator. The various sequences will enable systematic investigation of the oligomers folding behavior upon metal coordination. Conformational changes and chirality will be detected by Circular Dichroism (CD) spectroscopy. Based on our findings we will generate unique chiral sensors and multifunctional asymmetric catalysts: helical metal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of an ecological lubricant for forming and cutting applications' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Lubricants play a key role in the drilling and forming process, and mineral oil containing chloroparaffines are actually used. The performance of this lubricant is good but from environmental point of view has some drawbacks: . Contains environmentally friendly hazardous substances as chlorinated paraffin C10C13 (chlorine content 40% weight . Acute toxicity DL50/oral rat > 2g/kg, Marine pollutant: PP . Skin irritating, > 200°C traces of hydrogen chlorine gas . Risk of transformation in PCB at medium to high temperatures. The objective of this project is to develop an environmentally friendly lubricant optimising its forming and cutting (drilling) properties. Then the physico chemical requirements of the oil also will be improved by means of this project development. Actual technical requirements: . Melting point: 40 60°C (grease), Flash point >150 160°C (grease and oil), pH 9.2 (emulsion) New product technical requirement: . Melting point: 70 100°C (grease); Flash point 200 300°C (grease and oil), pH 8.0 9.4 (emulsion) New chemical requirements: Forbidden products: Chlorinated products, nitrites, nitrates, aromatics, boron compounds, heavy metals (Cd, Ni, Cr, Cu, V, Pb, Sb, etc.) New environmental requirements: . Biodegradable lubricant >70 80%, CEC L 33 A 94, Minimum toxicity. New social requirements: . Easy handling . Health protection due to toxic and biodegradable character . Easy and relatively cheap disposal . High versatility due to multipurpose application possibilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reverse engineering to optimise vehicle chassis dynamics' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objectives of this research relate to developing techniques to feed data obtained under live operating conditions into computer simulation programs for the prediction of vehicle chassis dynamics. The result will be a significant narrowing of the gap that currently exists between theoretical predictions and results actually obtained, thus offering improved performance and safety. The benefits will be that design processes will be quicker and more accurately focused, and that suspension component manufacturers will be able to tailor their products to specific motor industry requirements.