RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INNOVATIVE LIQUID BIOPSY METHOD USING LAB-ON-ACHIP TECHNOLOGY FOR CANCER DIAGNOSIS AND MANAGEMENT' (LUMEN).

assistant: **Innovation**

JaxBio is a pioneering biotech startup company dedicated to transforming lung cancer diagnostics and treatment through innovative liquid biopsy and DNA-chip technology. Our team, comprised mainly of Ph.D. experts in cancer biology, data science, and technology development, is committed to addressing the critical challenge of early lung cancer detection and management. The global impact of lung cancer, claiming nearly 1.8 million lives annually, highlights the urgent need for advanced diagnostic solutions. Over 70% of lung cancer patients are diagnosed at advanced stages, resulting in poor prognosis and high mortality rates. Furthermore, approximately 50% of patients receive suboptimal treatment due to a lack of methods to predict treatment response rapidly.  JaxBio addresses these challenges with LUMEN, an innovative non-invasive liquid biopsy assay. This method employs a custom chip designed for ultra-sensitive detection of epigenetic signatures in cell-free DNA, complemented by an AI algorithm for identifying disease-specific biomarkers. Our findings demonstrate LUMEN's ability to detect cancer early, even with extremely low tumor-derived DNA concentrations in the blood. Eliminating the need for DNA sequencing, LUMEN offers unparalleled accuracy in cancer detection as well as affordability. It also provides valuable insights for personalized treatment approaches and early tumor recurrence detection. With EIC support, our objective is to conduct clinical trials and complete the development of the lung cancer chip. This chip will serve as a companion diagnostic tool, predicting therapy response, and assessing treatment effectiveness. Our goal is to bring a clinically validated product to market, comprising reagents, chips, and analysis software, ultimately enhancing can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Sustainability of coffee agro-forestry systems in central America; coffee quality and environmental impacts'.

assistant: **Innovation**

The CASCA project proposes alternatives to intensive coffee rnonocultures, highly dependent on chemical inputs, unsustainable and environmentally damaging. This project is designed to provide tools to promote ecologically sound coffee agroforestry (AF) systems and management practices. The goal is to combine high coffee quality with sustainable modes of coffee production in Central America.The project will use an integrated, multidisciplinary approach focusing on the effects of shade trees and agricultural management on:(I) coffee physiology;(2) environment (water contamination, soil fertility and carbon sequestration); and(3) economic viability of coffee systems.The value of tree products and environmental services provided by these AF systems and the market potential of sustainable coffee in Europe will be assessed. The project will bring together experimenters, modellers, economists and end-users. It will provide policy guidelines for implementing eco-friendly coffee systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Removal of microplastics from the environment using autochthonous wastewater-derived microbial consortia'.

assistant: **Concept**

The accumulation of microplastics (MPs) in the environment poses a great threat to the biosphere. Known and demonstrated conventional methodologies used in the treatment of MPs in wastewater have several limitations. Therefore, there is the need to develop new eco-friendly, cost-effective biobased MPs (Polyethylene terephthalate-PET) removal strategies. Microorganisms can transform organic matter as well as remove pollutants through a chain of different catabolic reactions energized by the induction of non-stereoselective enzymes. Hence, this project will be the first attempt to deploy microbial autochthonous consortia as an eco-friendly remediation technique and strategy in the removal of MPs in the wastewaters. However, to overcome the limitations associated with cultivation and identification of MP degraders, I propose the use of a natural microbial consortium that harbours a plastic-degrading microbial community in wastewater after an enrichment process. Thus, in this project, an enhancement of microorganisms with catabolic capacity to transform MPs will be used for the development of a bio-based tailored technology, which represents the promising potential of this project. The overall objectives of this project are to: (1) characterize MPs in wastewater (2) isolate autochthonous consortium of MPs (PET) degraders in a short term enrichment experiment, study the microbial communities participating in MPs removal and identification of key genes in the catabolic process (3) select a microbial consortium with the ability to remove MPs and study of the fate of MPs in batch experiments (4) scale-up the process into a bench-scale bioreactor to develop a bioaugmentation technology with a microbial native consortium based on their ability to degrade MPs. (5) assess the toxic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High resolution single molecule imaging to determine the spatio-temporal rules of glutamate receptor trafficking during synaptic plasticity' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The regulation of neurotransmitter receptors localization at synaptic sites plays a crucial role for efficient neuronal transmission and plasticity. The molecular mechanisms that regulate receptor trafficking in and out synapses just begin to be unravelled . They include exo and endocytosis to insert and remove receptors from the plasma membrane, as well as receptor surface trafficking through lateral diffusion between the synaptic and extrasynaptic sites. These processes are highly regulated by neuronal act ivity, adaptor proteins and phosphorylation. The recent development of high resolution single molecule imaging in live neurons by the host laboratory has allowed to attain unprecedented precision in the determination of individual receptor movements in and out synapses. This has led to the demonstration that receptor diffusion in the plane of the membrane is a key process in regulating receptor numbers at synapses, and that the different types of glutamate receptors display differential activity-dependent r egulation of mobility.The aim of the present proposal is to further develop imaging approaches to provide a comprehensive insight into glutamate receptor trafficking paying particular attention to a real-time description of AMPA and NMDA receptor insertion and removal from the membrane. We will use innovative molecular tools (pH sensitive GFPs) and develop a combination of new imaging approaches (multi-color evanescent wave microscopy combined with single molecule tracking to investigate the relative contri butions of receptor exocytosis, endocytosis and lateral diffusion to the regulation of receptor number at synapses. By overcoming technical limitations others have encountered till now, our aim is to provide for the first time high resolution characterizat ion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploiting the pathophysiology of the gut towards innovative oral peptide delivery strategies' (NanoGut), addressing dissemination and exploitation.

assistant: **Impact**

The development of new oral drug delivery systems that will enable the absorption of therapeutic peptides to the systemic circulation is one of the greatest current challenges for the pharmaceutical industry and is the ‘holy grail’ of peptide delivery. Improved novel drug delivery systems are of utmost importance in order to fulfill the potential of this route of administration in the treatment of chronic diseases (e.g. type 2 diabetes mellitus), where daily injections are often required. There are various advantages of using nanocarriers for this purpose: they offer protection against chemical and enzymatic degradation, controlled release, targeting, tolerability and/or improved uptake and translocation resulting in enhanced bioavailability and greater therapeutic efficacy. I was the first to demonstrate that lipid-based nanocarriers trigger endogenous glucagon-like peptide (GLP)-1 and GLP-2 secretion in vivo after orally administered to mice. This effect can be exploited to develop a novel and unconventional drug delivery nanosystem as a promising strategy for the treatment of gastrointestinal disorders (e.g. type 2 diabetes mellitus, Crohn’s disease, ulcerative colitis). There are significant gaps in current knowledge that need to be addressed to make this possible. I propose a series of studies to answer the following key questions: -First, can we develop a dual-action drug delivery nanosystem that synergizes its own biological effect and that of the encapsulated bioactive molecule? -Second, can we ameliorate type 2 diabetes mellitus (T2DM) and inflammatory bowel diseases (IBD) using an oral peptide-loaded dual-action lipid-based nanosystem? –Third, is this innovative strategy a viable alternative to current treatments in T2DM and IBD? By exploiting the gut pathophy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Francesco Ingoli (1578-1649) as Political Thinker and Global Theorist'.

assistant: **Objectives**

The GlobalIngoli project investigates the significant yet unexplored role of Francesco Ingoli (1578-1649) in early-modern political thought. As General Secretary of the Congregation de Propaganda Fide for 27 years, Ingoli was essential in the Catholic Church's global evangelization. While previous studies have focused on his scientific controversies and bureaucratic role, this study emphasizes Ingoli's political philosophy and its effect on the Church's global vision. The research examines unpublished works such as the 'Istruzioni', and the 'Relazione delle Quattro Parti del Mondo' (ca.1633) to highlight their overlooked theoretical significance. It aims to expose Ingoli's innovative political thought, encompassing evangelization strategies, the intersection of religion and politics, and the gathering of geographical and cultural information. The study will enrich our comprehension of global interactions that influenced 17th-century political philosophy and trace the genealogy of the term 'propaganda.' It will provide insight into key debates in 17th-c Roman milieux, including the Church's unlimited potestas indirecta and novel governing techniques like ‘statistics’ and anthropogeography. By employing an interdisciplinary approach encompassing philosophy, political theory, law, and cultural studies, the research intends to shed fresh light on political thinking during the Counter-Reformation period. This 3-year project, involving the Universities of Venice, NYU and Brussel, will allow Dr Fabris to expand his expertise in early modern political philosophy and intellectual history. With his international experience in Europe and the US, he will deepen his understanding from a global political perspective, acquire new skills, work with top experts, and share his findings w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development and Application of Design and Integration Technologies for Industrial sub-critical Components Based on CMC-materials' (1994-1998).

assistant: **Innovation**

The project is part of a global research action by the energy industry sector, aiming at the implementation of a high efficiency, environmentally friendly Externally Fired Combined Cycle (EFCC) based on an Ultra High Temperature Heat Exchanger (UHTHE) for application temperatures up to 1500 C. Ceramic Matrix Composites are currently the most promising material class for this application. The expected advantages of the new system are higher efficiencies compared to concurrent technologies, low costs compared to the benefits and a significant reduction of critical emissions. The main deliverable of the proposed project is a produceable design of the internal part of the planned Ultra High Temperature Heat Exchanger (UHTHE) module. The sub-critical components consist of heat-exchanger tubes, carrier plates and implies the need for permanent joints and hot-gripping systems. The project will be based on three promising state-of-the-art materials, which are all available within the project The materials are one discontinuously reinforced CMC (DR-CMC) and two continuous fibre reinforced materials (CFR-CMC). At the end of the project, one design solution will be selected for prototype testing in a subsequent project. Several innovations will result from this project, which will promote the service introduction of CMC-materials. Main innovations to be expected are reliable software codes fulfilling industrial needs for life-time prediction of CMC components, reliable FE-modeling of brazed joints for ultra high temperature application and highly improved hot-gripping systems for un-fastenable ultra high temperature joints. The chosen approach will guarantee the best currently possible performance of the technologies, software codes and modelling methodologies to be developed. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Individual Differences in Environmental Sensitivity to Parenting' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Parenting is one of the strongest, most robust and consistent predictors of child development. Although parenting is important for all children, a substantial number of studies provide evidence that some children are more negatively affected by harsh parenting than other children. More recently, it has been shown that some of these “vulnerable” children also benefit more from supportive parenting: they are generally more sensitive to their rearing environment. However, these studies tend to rely on proxy markers of such Environmental Sensitivity (ES). Specifically designed measures of ES do currently not exist. We propose to develop a new observer-rated ES measure in early childhood and, applying this measure, investigate whether more sensitive children are more affected by both negative and positive parenting practices in middle childhood. Furthermore, we will explore associations between this new objective measure of ES and related temperament traits as well as gene variants, applying a multidisciplinary approach. The project is based on existing data from the on-going longitudinal Stony Brook Temperament Study. The Experienced Researcher, with extensive proficiency in parenting research and in the coding of child behaviour, will be trained to undertake this research with the support of the leading experts in the field. This project will significantly advance the field of developmental psychology by providing the first objective measure of sensitivity in early childhood which will allow for more precise empirical testing of Environmental Sensitivity. The findings of the proposed study will significantly deepen our understanding and insight into the interplay between individual difference in Environmental Sensitivity and parenting quality across childhood by applying a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Autonomic Balance for Adaptive Decision Making' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Why do some people make highly flexible approach-avoid decisions under threat, while others can only follow fight-flight impulses? Computational psychiatry has advanced formalizations on how utility functions shape optimal decisions. But decisions are made by embodied agents, equipped with potent and competing autonomic arousal systems: Approach-avoidance conflicts elicit stress and are marked by concurrent sympathetic and parasympathetic arousal. The impact of para- and sympathetic dominance on decisions is very different, but decision science has largely ignored autonomic balance, failing to explain altered decisions in real-life threats and anxiety.Leveraging theoretical innovations that bridge the decision and affective neurosciences, HEART2ADAPT develops a new framework to explain how our brains adapt value-based approach-avoidance decisions under the influence of our autonomic state. It will—for the first time—document the direct impact of autonomic balance on decisions in health and anxiety. HEART2ADAPT tests the hypotheses that: (1) sympathetic overdrive and failure to reach parasympathetic dominance makes anxious individuals misinterpret random environmental changes (noise) as actual threats, causing avoidance biases, while (2) parasympathetic dominance promotes integration of phasic amygdala-signaled changes with longer-term fronto-striatal updating, facilitating flexible decision making.To do so, HEART2ADAPT will (1) leverage groundbreaking innovations in the concurrent, real-time tracking of body-brain states (cardio- & posturography; high resolution MEG; fMRI/MRS); (2) pioneer focused ultrasound stimulation and cholinergic modulation to directly explore causal contributions of deep neural regions on decisions under threat, and (3) test these interventions i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Heterologous expression of natural products from microbes living in a self-sustaining environment' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The increases in antimicrobial resistance and infections caused by microbes, such as mucormycosis (black fungus disease) on Covid-19 patients, highlight the urgent need for new antimicrobial drugs. Most drugs approved for clinical use are based or inspired by natural products. The recurrent re-discovery of compounds when studying isolated microbes, declined the research on natural products in the last decades. However, isolated microbes represent a small percentage of the true microbial diversity living in the environment. Lichens are a microbial community formed by different partners (fungi, green algae, cyanobacteria, bacteria) and their metabolites present diverse biological activities including antimicrobial. Furthermore, many of these molecules have vibrant colours and can be used as natural colorants. Due their slow growth and difficulties in the laboratory cultivation, little is known about natural products biosynthetic genes of the multiple partners living in symbiosis. The improvement in high-throughput technology and the current affordable prices for multi-omics analysis (meta-genomics, -transcriptomics and -bolomics), are allowing a deeper study on natural environmental samples. This project aims to use the knowledge obtained in a recent multi-omics study and apply synthetic biotechnology, bioinformatics, chemistry and microbiology techniques to study novel metabolites from lichen. Polyketide synthase biosynthetic gene clusters have been selected and they will be cloned, transformed and heterologously expressed using Aspergillus oryzae. The optimisation of the polyketides biosynthesis by the heterologous host will be performed and different fermentation conditions will be tested. Novel molecules will be chemically and biologically characterized. During Fungal