RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Assembly and function of the chromosome periphery during mitosis' to be submitted under Seventh Framework.

assistant: **Abstract**

While chromosomes fill the nuclear space as decondensed chromosome territories during interphase, they are dramatically re-structured into compact rod-shaped rigid bodies during mitosis. The aim of my work is to elucidate the molecular mechanisms underlying this cell cycle-dependent chromosome reorganization. Unlike previous studies, I plan to focus on a yet poorly characterized chromosomal domain defined as ‘chromosome periphery’. I first plan to establish a detailed map of the proteins that target to the chromosome periphery in human cells, applying both high-resolution three-dimensional microscopy and superresolution fluorescence imaging techniques as well as molecular biology techniques, including chromatin immunoprecipitation combined with next generation sequencing (ChIP-seq) analysis. The combination of these approaches will provide me with information on different scales, first at the cell biological level and second at the DNA sequence level, to obtain a complete picture of the localization of the proteins that may organize the chromosome periphery. I will then investigate the functional relevance of chromosome periphery components in mitotic chromosome morphogenesis by RNAi screening in tissue culture cells. I expect that this work will provide insight into how a protein network sets up a chromosomal domain and how such a domain can contribute to the formation of mitotic chromosomes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Deconstructing Ageing: from molecular mechanisms to intervention strategies' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Over many years, our research group has explored the complex relationship between cancer and ageing. As part of this work, we have generated mouse models of protease deficiency which are protected from cancer but exhibit accelerated ageing. Further studies with these mice have allowed us to unveil novel mechanisms of both normal and pathological ageing, to discover two new human progeroid syndromes, and to develop therapies for the Hutchinson-Gilford progeria syndrome, now in clinical trials. We have also integrated data from many laboratories to first define The hallmarks of ageing and the current possibilities for Metabolic control of longevity. Now, we propose to leverage our extensive experience in this field to further explore the relative relevance of cell-intrinsic and -extrinsic mechanisms of ageing. Our central hypothesis is that ageing derives from the combination of both systemic and cell-autonomous deficiencies which lead to the characteristic loss of fitness associated with this process. Accordingly, it is necessary to integrate multiple approaches to understand the mechanisms underlying ageing. This integrative and multidisciplinary project is organized around three major aims: 1) to characterize critical cell-intrinsic alterations which drive ageing; 2) to investigate ageing as a systemic process; and 3) to design intervention strategies aimed at expanding longevity. To fully address these objectives, we will use both hypothesis-driven and unbiased approaches, including next-generation sequencing, genome editing, and cell reprogramming. We will also perform in vivo experiments with mouse models of premature ageing, genomic and metagenomic studies with short- and long-lived organisms, and functional analyses with human samples from both progeria patients a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Secretome analysis of intrathecally applied bone marrow stromal cells in experimental stroke'.

assistant: **Innovation**

Bone marrow stromal cells (BMSCs) have been shown to be neuroprotective after experimental ischemic stroke when given systemically. By this route of administration, however, over 99% of cells are trapped in lung, spleen and kidneys. This off-target distribution of BMSCs may result in serious ectopic side-effects thereby making their use in humans questionable.The applicant’s previous work has demonstrated that transplantation of BMSCs to the cerebrospinal fluid compartment (CSFC) reduces post-ischemic brain damage. The cells circulate in the CSFC, attach to ventricular walls and potentially undergo cell-host interactions. Nevertheless, their presence seems sufficient to provide suitable trophic support and promote tissue repair, suggesting a secretory mechanism of action (secretome). Whether the beneficial effect is solely due to the BMSCs secretome in the CSFC or to cross-talk mechanisms between BMSCs and the brain is not clarified. A better understanding of these potential modes of action offers a promising opportunity for future development of ""cell-free"" based therapy.In this project, we seek to go ahead by studying the CSFC secretome and the observed cell-host interactions of BMSCs after experimental stroke by using state-of-art techniques such as Laser Capture Microdissection and Mass Spectroscopy. The ultimate goal of the project is to determine whether a ""cell-free"" CSFC secretome, which is devoid of any cell-specific side-effects, recapitulates the effects of transplanted BMSCs.Taken together, this project will analyze the in vivo BMSCs-secretome after cerebral ischemia and will translationally demonstrate the pre-clinical proof-of-concept of a “cell-free” BMSCs therapy for stroke. Due to the high socioeconomic burden of stroke for Europe, novel and effecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Strengthening the role of women scientists in Nano-Science' under Sixth Framework.

assistant: **Concept**

WomenInNano is a 30 months project involving 11 women scientists from 9 European countries (Germany, Romania, Sweden, Spain, Slovenia, UK, Bulgaria, Italy, France). It represents a pilot initiative of networking high-level female scientists experienced i n Nano-Science who will act as Ambassadors for Women and Science". The aims of the project are: a) to encourage young women to consider studies and pursue careers in this new scientific field (providing "role models"), b) to attract youth to "NANO", c) to network and empower women scientists working in Nano-Science at national, regional and European level, d) to stimulate female scientists to participate in EU programmes, e) to mobilize stakeholders in favour of gender equality in scientific research, f) to stimulate the science-society dialog.The activities planned are logically grouped and described in eight workpackages. They can be separated into three stages/steps:In the first stage, after establishing the conceptual framework of the project (WP1 ), the team will review the state of the art in Nano-Science, will identify and map the competences and make a data base of women scientists in this field at national, regional and European level (WP2).In a second stage (WP3, WP4, WP5) mass media appear ances, participation at open and public events (of "Open house day", "Girls Day"-type), visits to schools, workshops, summer school are planned, all these representing a campaign to make the scientific career more attractive, especially for young women. This stage will also enhance the role of women scientists in the international "Nano" community and will help to further networking.A third stage (WP6, WP7, WP8) is dedicated to communicating and making contact with decision making-persons at national an d European level con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Future Mobile Information Access: Challenges and Opportunities'.

assistant: **Innovation**

The Mobile Internet offers a new age of anytime, anywhere information access to a potential user-base of approximately 4 billion people. Recently, new life has been breathed into the Mobile Internet as a result of a combination of significant device, content, infrastructure and billing improvements. As such an increasing number of users are venturing online via their mobile phones in search of interesting content. In fact, mobile devices are already becoming the primary mode of Internet access for a large fraction of the world’s population. However, the Mobile Internet represents a challenging information access environment due to the inherent limitations of the mobile space, limitations that go beyond simple screen size or network issues. Mobile users have information needs that are impacted by contexts such as location, time and activity. Furthermore, human beings are social creatures that often seek out new strategies for sharing knowledge and information in mobile settings. Mobile information access presents its own challenges and opportunities that go beyond those of traditional desktop-based information access. The goal of this proposal is twofold: (1) to understand mobile users and their information needs, (2) to investigate future mobile information access services. A key component in the design of effective mobile services is to understand mobile users and their needs. As mobile technology advances, we can come to expect new behaviours to emerge. This is especially true as diverse user groups adopt mobile technology and as experienced mobile users adapt to new paradigms in mobile interaction. This proposal will explore novel forms of mobile information access which move beyond traditional query-based search and towards discovery of content. Our goal is to build
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'European Modular Education and Training Programme in Safety Sciences for Medicines'.

assistant: **Objectives**

Background:In current drug safety education and training in Europe, an integrative and translational approach is lacking. This shortfall has been identified by EUFEPS. The IMI (‘Strategic Research Agenda’), the FDA and the EMEA have also characterised this fact as a crucial gap in the education and training of scientists evaluating the safety of drug candidates and new medicines. Scope and objectives:We present a new and unique pan-European education and training network, which solves this shortfall by developing and establishing a comprehensive modular Education and Training Programme in Safety Sciences for Medicines (SafeSciMET). This programme will fulfil the needs of pharmaceutical industry, regulatory authorities and academia. The network, consisting of top institutes for drug safety education and research, proposes a new type, high quality and sustainable programme for education and training in Safety Sciences for Medicines (S2M). The tailor-made training modules will encompass the safety, ethical, regulatory and societal aspects in all phases of drug development, with emphasis on integrative, translational and 3Rs aspects of drug safety assessment. Individual safety professionals who wish to address specific knowledge gaps will be able to follow single modules. The modular set up also provides an excellent opportunity for following dedicated sub-sets of modules, to be accredited for Continuing Professional Development (CPD). Scientists successfully completing the full programme, including an integrative MSc-thesis, will be awarded with an accredited Master of Advanced Safety Sciences of Medicines (M4S2M). All training modules and procedures will be aligned with the Bologna process. Principle learning outcomes are novel competences in translational safety sciences
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Memory, Beliefs, and Economic Decisions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project builds on the psychology of memory to study how selective retrieval affects economic decisions by shaping beliefs and preferences. The general approach is one in which a person’s past experiences (both domain relevant and domain irrelevant) determine her “core” beliefs and preferences, but changing cues in the environment ignite selective retrieval of specific pieces of information, causing instability in beliefs and preferences. In this way, selective memory acts as a source of framing effects. One project studies belief formation, which is based on sampling of information shaped by similarity to cues (which include the hypotheses being assessed and irrelevant context) and by interference. A second project applies this approach to preferences, studying choice under risk (whereby people selectively retrieve from memory and simulate potential lottery outcomes) and intertemporal choice (whereby people use memory to simulate future rewards). A third project will apply these ideas to the field. Domains of interest are: i) survey measurement of how past domain relevant as well as domain irrelevant experiences shape the perception of new risks i) socio-economic identity and its effect on political opinions, ii) similarity in financial markets, beliefs and asset prices, iv) advertising, and v) instability of fairness norms.


**Keywords:** memory, beliefs, intertemporal choice, valuation, political opinions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Reunification of the German Churches, a Clash between two Identities', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and contentChurches are influential in Germany on the federal level as well as in the individual Lander In the context of the fall of the Berlin wall and of the transition, the German Wende, the churches could but join the effort of reunification imposed by the federal government. The Catholic and Protestant churches have taken different steps. The Catholic church was favoured by a supranational structure which led to unification in a rapid process.On the other hand, the process was more complex and slower for the Protestant territorial churches which had greater autonomy. To this day, no research has been conducted into the impact of the reunification on the churches both in East and West Germany. Eight years after the reunification, there is a dire need for an assessment of the situation.An assessment of the impact of the reunification brings in a lot of information concerning the relations between East and West. Can we really say the churches have been remodelled following the Western pattern? Have the churches totally lost their former influence in the new Lander? What role do they play in the question of the identity of East Germany? Is this role specific? The East-West dialectic constitutes the foundation of the current study.Training content (objective, benefit and expected impact)The current study must bring to light the deep motives for the tension between the two Germanies. This research also proves the need for a reassessment of the relations between the Church and the State in a secularised society. This study must finally emphasize some factors for the claim to identity in the former East Germany. The difficulties linked to the transition toward a market economy have stirred up the need for an East German identity. The conclusions of thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spark Ablation for Nanotube Growth' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Carbon annotates grown by chemical vapour deposition or carbon arc method are fairly cheap but contain considerable amount of defects and therefore the electrical and mechanical properties are far below their theoretical limits. In the laser ablation technique, annotates are produced under much better control of carrier gas flow and thermal gradients, but throughput is low and lasers are expensive. In channel spark ablation thermal gradients and gas flow are similar, but the process is much cheaper. The Arc-Jet method improves the flow conditions in the carbon arc (Kraetschmer) generator by injecting the carrier gas through a nozzle into the electric arc. The consortium will set up generators for channel spark ablation (Bologna), laser ablation (Stuttgart), and Arc-Jet production (Shanghai) and compare the products from these methods. To this end procedures for quality control and quality standardisation will be developed. These methods are based on optical and Raman spectroscopy, X-ray diffraction, and thermo gravimetric analysis, as well as on mechanical investigations and electrical and thermal transport measurements (on pressed pellets, entangled films, and composites). The Austrian company AT&S Austria Systemtechnik AG is one of the largest producers of printed circuit boards. There is a general tendency to make these boards smarter" and to transfer passive electronic elements (resistors and capacitors) from the chips to the boards. AT&S envisages to use the annotates produced in this project for electronic elements integrated into their boards. AT&S has just started a subsidiary in China so that both the Chinese daughter and the European mother are likely to benefit from this project. The present project will produce high quality annotates at much larger quantitie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'International symposium on functional foods: scientific and global perspectives' to be submitted under Fifth Framework.

assistant: **Abstract**

The concepts of food have expanded from an emphasis on survival to a growing interest in foods and bioactive food components that promote health and well being, and reduce the risk of disease. The International Symposium on Functional Foods: Scientific and Global Perspectives will be held in October 2001, to acknowledge the importance of this new field, and improve our understanding of the role food holds in enhancing health and well being. In four sessions, four panel debates and five poster sessions, the scientific basis, global views and concepts, health benefits, safety aspects, human variability factors, communication enhancement and future development of functional foods will be reviewed. The proceedings and panel discussion summaries will be published in a scientific journal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Steady-state and demand-driven dendritic cell generation' (DCPOIESIS), addressing dissemination and exploitation.

assistant: **Impact**

Classical dendritic cells (cDCs) are leucocytes that play a key role in innate immunity as well as the initiation and regulation of T cell responses. cDCpoiesis starts with commitment of a bone marrow (BM) haematopoietic progenitor, known as the classical DC precursor (CDP), to the cDC lineage. CDPs then give rise to pre-cDCs that exit the BM via the blood and seed tissues to give rise to the two major types of fully-differentiated cDCs, the cDC1 and cDC2 subsets. The key parameters of cDCpoiesis are poorly understood. We propose to characterise the niche in which cDCs develop within the BM and to study how pre-cDCs seed tissues and establish local clones of differentiated cDC1 and cDC2. We further wish to ask how the activity of CDPs and pre-cDCs is altered following infection, inflammation or tissue damage. Finally, we want to know to what extent cDCpoiesis is affected by direct sensing of infection or cell damage by cDC precursors. All these objectives will be addressed in a mouse lineage tracing model in which cDC precursors are genetically labelled through the activity of a Cre recombinase driven by the Clec9a locus. These mice will be crossed to fluorescent protein reporter mice, including Confetti mice that allow for clonal analysis, and the appearance of labelled cDCs and cDC clones in tissues will be followed over time in the steady-state or after induction of infection or inflammation. The dependence of cDC precursor activity on specific pathogen and damage sensing pathways will be assessed by loss-of-function experiments. The interactions of cDC precursors with their BM niche will be analysed in steady-state or inflammatory conditions by visualising the cells in situ. Finally, the consequences of demand-driven cDCpoiesis for immunity will be assessed. The res