RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Establishing a strong and lasting international training network for innovation in food and juice industries: a 4D-research approach for fruit juice processing'.

assistant: **Objectives**

HiStabJuice is a European intersectoral and interdisciplinary network offering research training to 11 ESRs, which is relevant to the entire food industry worldwide. Initiated by the International Fruit and Vegetable Juice Association (IFU), the ETN combines the scientific expertise of 5 universities and 2 research institutions with the technological experience of 10 industry partners from7 EU countries. This ETN stands out by its exceptionally high industrial involvement that ensures training in real world ability and in solving key problems with exceptional analytical and technological skills combined with training in key transferable skills for public and private sector employment. The ESRs will work together on the evaluation of various factors influencing colour stability in fruit juices, focussing on raw materials and preservation techniques, as well as associated effects, deleterious to the health benefits of the final products. Pioneering aspects include the first empirical analysis of the contribution to colour stability and nutritional value of thermostable enzymes, fruit variety, ripeness, harvest time, traditional and modern preserving techniques (pasteurization, freezing, pulsed electric field, ohmic heating, high pressure processing), which will be evaluated in a 4D approach (microbes, enzymes, nutrients and chemical-physical parameters). Upon conclusion of the action, the ESRs will have established a universal, empirical system for deciding which fruit types to harvest at which times, at which stage of the ripening process, and which preservation method will give the best colour and nutrient stability. In line with the Horizon2020 strategic priority of Open Science this knowledge will be freely accessible. This has the potential to revolutionise the fruit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Schroedinger operators: from measure convergence to spectral convergence' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The proposed project is aimed at the study of Schroedinger operators, which are differential operators of second order, used for modelling the behaviour of a quantum particle interacting with various types of potentials.The objective is to approximate Schroedinger operators with one type of potentials by operators with another type of potentials, where the latter are solvable in the sense that their spectra are easy to calculate. It would yield an alternative method to compute the spectra in situations when a straightforward solution of partial differential equation is impracticable.A special attention will be paid to singular potentials, namely the point potentials, as they represent a solvable model and they have been already successfully used for such approximation.Due to the singular character of the potentials, first step is to explore the measure convergence of the operators, next step is to explain how it is reflected in the operator convergence and finally, one has to investigate the spectral convergence. Then the approximation will be eventually applied to particular, physically interesting systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Beyond the Silk Road: Economic Development, Frontier Zones and Inter-Imperiality in the Afro-Eurasian World Region, 300 BCE to 300 CE' (BaSaR) targeting Horizon 2020.

assistant: **Abstract**

This interdisciplinary project will show that inter-imperial zones and small to mid-size regional networks of exchange were crucial for ancient Transeurasian exchange connections. It will demonstrate the significance of exchange in imperial frontier zones emerging from political, economic, infrastructural, institutional and technological development within empires. This will lead to a new conceptual frame for analyzing inter-imperiality and the morphology of exchange networks within and across imperial zones.The centuries from 300 BCE to 300 CE were a period of accelerated empire transformation involving also new regions of the Afro-Eurasian world. Consumption centres shifted, affecting production, settlement, and regional exchange networks. They changed the dynamics of exchange, created new geographies, and greater cultural convergence between imperial spheres of influence. The development of imperial frontier zones of intense exchange and mobility (e.g. Northern China, Bactria, Gandhara, Syria, and the Red Sea/Gulf/Indian Ocean coasts) was related to imperial hinterlands, their fiscal-military-administrative regimes, the development of media of exchange and infrastructures, settlement, urban growth, and so on. It was also related to new forms and levels of consumption in imperial centres. In order to understand Transeurasian connectivity, the interdependence of frontier zone and inner-imperial development is crucial. We will reveal that competitions for social power within empires mobilized and concentrated resources reclaimed from natural landscapes and subsistence economies. Greater mobility of resources, both human and material, endowed competitions for power with economic force, feeding into inter-imperial prestige economies and trade. This new model of Afro-Euras
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structure and evolution of genes encoding glyceraldhehyde-phosphate deshydrogenase in lower eucaryotes such as euglena gracilis', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

My project consists in doing the analyses various genes encoding isoforms of the glyceraldehyde 3-phosphate-deshydrogenase (GAPDH) in protozoa. GAPDH is an enzyme of the glycolytic pathway, a very ancient energy-providing process, present in all living cells, from bacteria to animal cells. GAPDH is an excellent marker to study cell evolution at the molecular level because the various GAPDH isoforms are considered to originate from different primitive organisms, having given rise to the present day cells by an endosymbiotic evolution. Protozoa, specially the primitive ones, are very diverse in structure. They may represent different primary ways of cell construction and evolution from which the present animal and plant phylla originated. This aims to fill the gap in understanding the variety of protozoan organisms and from which type of organisms such primary cells originate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strengthening democratic governance for climate transitions' (RETOOL).

assistant: **Concept**

The overall goal of the RETOOL project is to advance our understanding of how to address the twin challenges of responding to the climate imperative while strengthening and reinvigorating democratic governance. The project has four overarching objectives: (i) To deepen our understanding of the relationship between democratic governance and the climate imperative by developing a novel analytical framework and creating new empirical underpinnings, including important new open-access datasets; (ii) To understand how a variety of democratic institutions across Europe are responding to the climate challenge, including learning lessons from history and studying new and innovative democratic practices; (iii) To contribute to reinvigorating democratic governance in Europe by developing and synthesising new knowledge and insights on climate democracy, and presenting them in a range of high-impact formats; and (iv) To serve as a bridge between academic research on climate democracy innovations and policymakers and practitioners, as well as civil society and the wider public. RETOOL brings together an international and interdisciplinary consortium, with partners from Western Europe (Ireland, UK, Belgium, Austria), Northern Europe (Finland), Eastern Europe (Estonia), and Southern Europe (Italy, Greece), combining expertise in political science, political sociology, deliberative democracy, environmental law, European studies, and public administration. The consortium includes a democracy practitioner foundation, and all partners are closely associated with practitioner and civil society networks and involved in hands-on activities. RETOOL will be undertaken by a mature, settled consortium that has significant experience of working together, with six of our nine partners core members
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Use of embryonic stem cells and organotypic spinal cord slice preparations to establish cell-based therapies for spinal cord injury', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The disruption of spinal cord motor and sensory pathways following traumatic injury has devastating consequences for damaged patients. Regenerative strategies include the use of cell-based therapies to bridge the lesion. The main objective of this project is to investigate and optimise therapeutic strategies for spinal cord injury (SCI) by combining cell-based therapies with concurrent or sequential application of neuro-protective and/or regenerative pro-factors. We intend to obtain neural-derived embryonic s tem cells to be used for transplantation as prime experiments reported shed hopeful results. However, several questions remain unsolved critical to plan optimised therapies. One of these issues is the mechanism involved regenerative event after cell grafting. By using genetically engineered embryonic stem (ES) cells, we should be able to determine whether regeneration is specifically promoted by cell integration itself into the repaired tissue or by the factors released by them.An optimal therapeutic strategy for SCI using ES cells will be selected using an in vitro model for neurotrauma based on organotypic spinal cord slice preparations. The establishment of this model is another objective of the project and should facilitate the efficient screening of a broad spectrum of factors in combination with cell graft. It may reduce notably the number of animals destined for this purpose. The most advantageous strategy, derived from this screening will be analysed in vivo on murine models for SCI and functional recovery will be evaluated by a complete battery of electrophysiological and behaviour tests. In summary, the accomplishment of those objectives should shed light into essential neural regenerative processes, may provide innovative systems for high-throughput scre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genome maintenance and evolution' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Genome maintenance describes a subset of conserved cellular processes responsible for the faithful propagation of genomes across cell divisions. Defects in genome maintenance have been associated with several medical disorders such as cancer, aging and developmental defects. Recently we showed how perturbations in DNA replication, one of the most conserved processes in genome maintenance, induce an evolutionary process that leads to the sequential and concerted accumulation of adaptive mutations that increase the cellular fitness in response to replication stress. To what extent this fast-evolutionary rescue applies to other defects in genome maintenance, and what evolutionary trajectories are responsible for adaptation under different cellular stresses remain unexplored questions. Furthermore, while adaptive mutations rewire genetic networks to achieve increased fitness, their pleiotropic effect on cell biology is unknown. Here I propose a plan to comprehensively investigate these questions by taking advantage of a multi-disciplinary methodology using the budding yeast S. cerevisiae as a eukaryotic model organism. Experimental evolution of cells perturbed in several aspects of genome maintenance will be combined with computational and quantitative approaches to study their evolutionary adaptation in response to the different initial perturbations. Molecular genetics and cell biology techniques will be then used to investigate the consequence of these adaptations to cell’s sensitivity to genotoxic agents, a phenotype directly relevant for the treatment of medical-relevant diseases including cancer and infection diseases. The knowledge generated by the proposed research project will reveal important aspects of how cells adapt to genetic perturbations, with implications f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Morphing Locally and Globally Structures with Multiscale Intelligence by Mimicking Nature', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of the proposed research is to engineer novel multifunctional morphing materials drawing inspiration from biological systems that are known to possess distributed sensing capabilities which in turn guide their local and global morphing. This will be achieved through the development of novel multi-scale technologies (nano- to macro) and materials that, once integrated, will allow distributed local/global sensing and morphing capabilities that can be exploited for structural as well as for eminently flexible applications. The distributed local/global morphing and sensing will be delivered by fabricating at the microscale a non-invasive, light-weight, flexible and highly expandable active network with enhanced actuation capabilities and a neurological sensor network. The networks are then expanded to the macro-scale prior being integrated in a flexible material or in an innovative multi-stable shape memory carbon-fiber composite. The sensor network has to monitor environmental and loading conditions. These data are then used to control the deformation of the active network which can deliver local (roughness changes as in dolphins skin for instance for drag reduction) or global morphing (e.g. for deformable textiles as in insect wings) in flexible materials. The multi-stable carbon-fiber composite can be used in conjunction with these two functions so as to achieve advanced morphing in structural applications (e.g., birds wings vs. aircrafts wings). The composite, with a shape memory resin as hosting matrix, due to its rigidity and sensitivity to temperature variations, can snap from one configuration to the other. The speed of the purposefully-introduced snapping-through process will be tuned with the help of the integrated active network. This research has t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Perception Ultrasound by Learning Sonographic Experience' in the context of a Horizon 2020 call.

assistant: **Objectives**

PULSE will develop a new generation of ultrasound imaging capabilities to revolutionize the use of this low-cost and portable imaging technology across clinical medicine worldwide. The greatest barrier to the universal implementation of ultrasound (US) in clinical medicine today is the need to train sonographers to the highest level to ensure diagnostic images are of consistently high quality and fit for purpose. Unfortunately, the non-expert finds US images very difficult to interpret by eye alone.  Perception Ultrasound by Learning Sonographic Experience (PULSE) is an innovative inter-disciplinary project designed to eliminate the need for highly skilled operators of the technology. It is motivated by the observation that sonographers find it easier to interpret their own scans than review those taken by others. The innovation in PULSE is to apply the latest ideas from machine learning and computer vision to build, from real world training video data, computational models that describe how an expert sonographer performs a diagnostic study of a subject from multiple perceptual cues. Novel machine-learning based computational models will be derived based on probe and eye motion tracking, image processing, and knowledge of how to interpret real-world clinical images and videos acquired to a standardised protocol. By building models that more closely mimic how a human makes decisions from US images we believe we will build considerably more powerful assistive interpretation methods than have previously been possible from still US  images and videos alone.     Software demonstrators will be developed and evaluated on real world obstetric US data in collaboration with clinical experts and novices to demonstrate the new approach and its potential to move routine US scanning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification of bat antiviral innate immune effectors' to be submitted under Horizon Europe.

assistant: **Abstract**

Numerous recent disease outbreaks have been linked to zoonotic viruses originating from bats, including Marburg, Nipah, and the severe acute respiratory viruses like SARS-CoV-2. Countless virus-host encounters during bat evolution have shaped chiropteran immunity to balance defense and tolerance to viral infections, ultimately participating in bats current interplay with viruses and capacity as a viral reservoir.One of the first barriers against invading pathogens is the innate immunity, which notably includes antiviral factors that directly or indirectly inhibit the replication of invading viruses in the host cell. Recent research on bats showed the functional diversification of several antiviral effectors underscoring their pivotal role in bat immunity. However, because only a handful have been studied, my goal is to identify key and novel antiviral effectors within bat genomes, employing a bioinformatics-driven approach coupled with cellular and molecular virology techniques. First, I will perform genomic, transcriptomic and phylogenomic analyses to identify the genes expressed in immune pathways and under strong positive selection during bat evolution (denoting their in vivo importance). Second, I will characterize the most promising candidates, by genetic knockout and overexpression of variants in bat and human cell lines. Finally, the antiviral activity of the candidates will be tested against a broad spectrum of viruses: retroviruses, positive- and negative-strand RNA viruses.Taken together, the proposed project will not only identify novel antiviral factors in bats, which are also active in human cells, but will also shed light on the adaptive processes of chiropteran innate immunity, which occurred during bat evolution.


**Keywords:** bats, innate immunity, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multiwavelength spectral timing of black holes and neutron stars: a new step in our understanding of accretion processes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Accretion is a common physical process in the Universe, playing a crucial role in galactic and extra-galactic astronomy. Accretion can be studied in detail by looking at black holes and neutron stars in low-mass X-ray binaries (LMXBs), where changes occur on timescales favorable for human studies. X-ray observations of these systems during the last decade have revealed that accretion proceeds via various accretion states. Optical and near-infrared (OIR) emission was thought to originate from thermal reprocessing of the X-ray emission by the accretion disc. Recent spectral and timing multiwavelength studies are, however, challenging this classical scenario. The new studies show that a relativistic outflow in the form of a jet plays an important role in the accretion process. Key to these new works are fast, high signal-to-noise OIR observations. However, these new studies are not systematic in the sense that only a few accretion states and sources have been covered. The proposed project would provide the systematic study by determining the origin of the multiwavelength emission via a spectral and fast variability study covering all the accretion states observed in both neutron stars and black holes. To this end I have gathered an extensive database of simultaneous, high time-resolution X-ray, optical and near-infrared observations, and the host is a leading institute in new radio facilities like LOFAR and MeerKAT, which will provide guaranteed data to the project.Both spectral and timing analysis tools will be applied to the data set. For the interpretation I will use two numerical codes that will allow me to interpret the simultaneous high time resolution X-ray and OIR data.