RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecules as electronically open quantum systems' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

To control chemistry we must understand it, and this requires a fundamental quantum mechanical description. Today we have a highly mature state of accurate quantum chemical modeling of molecules. A central assumption in these models is that the molecules have a fixed number of electrons, i.e., that they are electronically closed.  Recent experiments show great promise for probing chemical understanding and inducing chemical reactivity by passing a current of electrons through the molecule. Hence, quantum chemical models which can treat molecules as electronically open quantum systems are urgently needed.  The mission of OpenQuantum is to establish the field of electronic wave function theory for electronically open systems.  I will establish high-level models within the open quantum system formalism  and develop it into a validated computational toolbox. Computationally efficient and versatile wave function implementations connected to multiscale environment models provide tools for investigating ground and excited state properties under open conditions. I will provide a detailed theoretical and computational description of how molecules are modified through electric currents, and explore possibilities that emerge in chemistry through fundamental knowledge of molecules as open quantum systems. The new methodologies and insight that OpenQuantum will bring are crucial to push the underlying understanding of excited states and redox stability of open molecules toward the use of electric current to catalyze and modify chemical reactions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pharmacological therapy to curtail visual loss in ADOA mouse model' (PHERADOA).

assistant: **Concept**

Autosomal dominant optic atrophy (ADOA) is the most common hereditary neuropathy that affects 1:35.000 people worldwide. A progressive visual loss is a characteristic of ADOA, and a treatment is not available. Mutations in the nuclear gene Optic Atrophy 1 (OPA1) in ADOA patients promote low levels of OPA1 protein, causing Retinal Ganglion Cells (RGCs) degeneration leading to blindness. OPA1 is the key component for mitochondrial inner membrane fusion mechanism and controls cristae biogenesis and remodeling, affecting cytochrome c release and apoptosis. So, mutations in OPA1 in RGCs may affect mitochondria integrity and lead to insufficient energy supply in the optic nerve.  The role of OPA1 in ADOA-RGCs remains elusive since ADOA mouse models show inconclusive and no RGCs specific results. To address this issue, Dr. Luca Scorrano developed an ADOA mouse model of conditional RGCs OPA1 depleted. In this model, RGCs show fragmented mitochondria and excluded from axon but combined with autophagosomes in the axonal hillock. But a genetic autophagy inhibition restores mitochondrial distribution in the RGCs axon and curtails visual loss in the ADOA animal. These data suggest that autophagosome accumulation reduced axonal mitochondria content in RGCs by an impairment of the mitochondrial traffic. Therefore, we propose that visual loss of ADOA mouse model will be prevented by restoring its axonal mitochondrial content through a local use of inhibitors of the autophagy process. This proposal aims to develop a pharmacological therapy to curtail ADOA mouse visual loss. For this, we will deliver autophagy inhibitors through vitreal nanocarriers implants in ADOA mouse model which is conditional RGCs-OPA1 depleted. This research will contribute to provide a pre-clinical approach for a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Scaling fluid-driven processes: Building Collapse in Extreme Flow Conditions'.

assistant: **Concept**

Many Earth system processes involving multi-physics, multi-phase conditions extend over several orders of magnitude in length- and time-scales. Engineering science, in pursuit of deeper process understanding and solution-oriented design, has used scaling theories to address scale-afflicted, complex processes through experimental work in laboratory environment at reduced scale. The standard scaling approach, the Buckingham -theorem, is especially deficient when multi-physics and multi-phase processes require the choice of more than a single non-dimensional number, resulting in severe scale effects and typically meaning that accuracies at reduced scale are inadequately quantified. Hence, we choose a demonstrably complex multi-physics, multi-phase process for the investigation of scaling accuracies  the progressive collapsing of residential buildings and the associate debris transport, evolving from extreme flow events from natural hazards, such as flash floods or tsunami.ANGRYWATERS seeks to achieve a breakthrough in modelling these complex processes by deriving novel scaling laws that will be developed in the framework of the Lie group of point scaling transformations. Scaling requirements will be applied to the combined fluid-structure interaction at various scales, developing sophisticated building specimens; here, we employ 3D-printing and appropriately engineered materials to match the scaling requirements. We conduct a comprehensive experimental campaign, using medium- and large-scale facilities, subjecting the specimens to extreme flow conditions in the form of dam-break waves. We consider sub-assemblages, single and multiple buildings, enhancing the understanding of energy losses and debris production upon collapse, elaborating reduced scale accuracies. High-fidel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Future Regional Aircraft Requirements Study' in the context of a Seventh Framework call.

assistant: **Objectives**

A study to investigate and assess the requirements associated with future Regional Aircraft in terms of future 'green' and other operational 'scenarios' and constraints, as seen by the Regional Airlines. The aim of the study lies in the identification, analysis, assessment and trade-off of the identified requirements in order to define the most 'optimum' combinations of these, overall. The results of the study will 'feed' the related design and technologies' development efforts under the CSJU GRA ITD. Representatives from various European Regional Aircraft Operators will be interviewed so as to establish the benchmark for the related study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular intervention strategies targeting latent and lytic herpesvirus infections' to be submitted under Sixth Framework.

assistant: **Abstract**

The consortium will create innovative opportunities for the application of the novel technologies of three SMEs in the development of a new generation of anti-herpes-virus treatments. Herpesviruses cause some cancers and many human diseases varying from afflictions of moderate severity that none-the-less can cause extended morbidity, to serious infections that are life threatening. This is particularly true in immuno-compromised patients including transplant recipients and HIV-infected individuals, but even in healthy people herpes-viruses can cause serious problems, for example during childbirth. Congenital HCMV infection is a leading cause of birth defects, and HSV-2 infection necessitates birth by Caesarian section.At present the options for antiviral therapy are extremely limited, and, because of toxicity, the current anti-herpes drugs cannot be administered to pregnant women. There is a continuing need to develop alternative treatments because drug-resistant viruses are evolving. The technologies that are being developed by three SMEs in TargetHerpes will be applied in connection with the fundamental advances being made in Europe's leading herpes-virus research laboratories, to press forward the search for novel, effective treatments that can be used against a broad spectrum of herpes-virus diseases.The project will target different herpes-viruses at different stages of their infections in order to inhibit virus; entry, evasion of host defences, persistence in infected individuals, reactivation from latency. These objectives will be achieved by improving and using the reagents and methodologies of the SMEs, thus providing opportunities in product development and marketing, and a foundation for the SMEs in the commercial development of successful treatments and meth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Engineering Eco-Friendly and Sustainable Reflecting Crystals in Yeast to Replace Hazardous TiO2 Based Pigments' to be submitted under Horizon Europe.

assistant: **Abstract**

The superior optical properties and stability of Titanium dioxide (TiO2) has made the material attractive to many industries, for use in food, cosmetics, and pharmaceuticals. Despite these benefits, the wide use of TiO2 has raised significant health concerns, culminating in the 2022 European Union's decision to ban its use as a food additive. This regulatory shift has precipitated an urgent demand for healthier, environmentally sustainable alternatives that do not compromise on performance. Unfortunately, current alternatives fail to match TiO2 in terms of efficacy and stability, thereby limiting their adoption. This PoC, proposes an innovative solution by which yeast serve as eco-friendly ""biofactories"" to produce guanine crystals. These crystals, which are naturally utilized by animals to reflect light, possess remarkable optical properties, with enhanced thermostability, and superior compatibility compared to current TiO2 alternatives. We will modify yeast to express the specialized highly efficient guanine-producing enzymes, originally identified in zebrafish as part of our ERC project. Inspired by nature, our project will exploit yeast's remarkable biosynthetic abilities to obtain efficient production of these crystals. Our preliminary results demonstrate the feasibility of this approach, and are backed by robust metabolomic profiling that enables precise measurement of guanine levels, identification of metabolic bottlenecks, and detection of by-products. In preparation for commercial rollout, our strategy involves mapping our innovation within the EU food industry, identifying precise market segments, and crafting an initial business model. This multifaceted approach is designed to both showcase the economic viability and market potential of our yeast-produced g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'InNOVATIVE TRAINING HORIZONS IN APPLIED SOLAR THERMAL AND CHEMICAL TECHNOLOGIES' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The PSA is a unique European center for experimentation in the field of applied concentrated solar energy technologies. Its broad range of facilities enable testing in such different areas as detoxification of industrial effluents, production of fine chemicals, thermal treatment of advanced materials, development of control algorithms for industrial heat transfer processes, desalination of sea water, bioclimatic architecture component research, convective drying of food products and direct solar generation of electricity. The PSA opens its doors to research groups interested in educating their personnel in the applications of these new technologies. Through the performance of innovative experiments, researchers will learn to apply environmentally benign solar energy to industrial processes. They will enjoy the benefit of both expert consulting by Area Heads as well as the services of supporting personnel. The result will be the creation of a new generation of researchers throughout Europe who, through their newly acquired know-how and experience, will be able to apply the 'solar option' to diverse multi-disciplinary fields of science and technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Translating the Image: Art, Science and Global Imagination in the first Islamic Description of the New World (Tarih-i Hind-i Garbī / History of the West Indies), 16th-20th Centuries' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

America-Islamica investigates a little-known and unstudied corpus of illustrated and painted books known as The Tarih-i Hind-i Garbi (History of the West Indies) or the New Hadith, and in Persian translation as the Tarjuma-yi tā’rikh-i yangī dunyā (Translation of the History of the New World). The first non-indigenous and non-European history of the Americas, this account of the Spanish conquest and colonization was composed in Ottoman Turkish in Istanbul based on Italian translations of Spanish sources in the 1580s. Manifesting rich layers of multidirectional translation, the work’s journeys, crossings, and circulations in text and image, geographically and temporally—from Spanish and Italian to Ottoman Turkish, Persian and French, from the Americas to Spain, Italy and the Ottoman capital to Iran and India, and more recently to Europe and the U.S., and from manuscript to printed editions in form that span three centuries—speak to the esteem, admiration, wonder, and appeal it exuded. Inherently interdisciplinary, this study will introduce the work to a wider contemporary audience. An in-depth analysis of its text and image in various formats, languages and canons, will enrich our understanding of early modern travel and colonization from the perspective of the non-colonizers, who were acutely curious and interested in knowing about the confines of the earth, and in competing for its domination.


**Keywords:** Islamic art history, early modern history, global history, Ottoman, Ottoman Turkish, Persian, visual translation, manuscript and print arts and cultures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Market Uptake Measures of Floating Offshore Wind Technology Systems (FOWTs)' (FOWTs), addressing dissemination and exploitation.

assistant: **Impact**

MARINEWIND is a 36 months coordination and support action that will identify bottlenecks and potential opportunities to strengthen floating offshore wind's technology FOWT role in delivering innovative solutions to system integration and will consider how best to integrate such a system by exploring the market, policy and regulations issues, social, financial and techno-economic optimal solutions, and provision for storage and flexibility recommendations. The MARINEWIND methodology is based on the analysis of the MARINEWIND Labs, that are social, environmental, technological and financial pilot studies based upon a multi-faceted data collection and analysis on barriers and enablers related to: a) policy measures (WP1); b) societal engagement and environmental impact (WP2); c) financial solutions, techno-economic implications and commercialization of FOWT (WP3). The MARINEWIND Labs are located in five countries: Portugal and UK (actual applications of FOWT) and Greece, Spain and Italy (planned applications of FOWT). These Labs will support the transfer of knowledge from the established experiences to the potential FOWT sites where plans for installation of FOWT are still at various stages of planning or implementation. The MARINEWIND Labs will involve the Quintuple Helix stakeholders (industry, academia, public authorities, civil society and green innovation). The threefold analysis will be conveyed into the MARINEWIND web based Geographical Information System (webGIS) which will provide specifically tailored information on FOWT to the various stakeholders on the basis of their category, geographical location and their goals and policy recommendations on how to have more informed RES policy and how to increase societal acceptance (WP4). The Replicability Plan will suppor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced measurement tool for nano particles size in deposition processing' (NANOPRIM).

assistant: **Concept**

The present project aims at developing an on-line gas phase nano particle measurement tool that can be used for various manufacturing processes in the nano-technology domain. Specifically, within NANOPRIM, the particle sizing measurement apparatus will be designed, developed and then integrated into a unique nanoparticle deposition process of nanocrystalline layers for the fabrication of novel catalytic sensors. These sensors were demonstrated to have a high sensitivity in detecting gas, but with the current end-of-line measurement of the ready deposited layer, the response is ambiguous and the layer is vulnerable to aggregation.The characterisation tool will enable a radical improvement of the deposition process because none of the state of the art methods and tools are nowadays able to measure gas phase particles of 5-20nm size, even in case of low-density. This improvement will led to many applications among which applications in the automotive industry, as defined by FIAT RC, member of this consortium.This project will explore a new frontier of knowledge by:-understanding and controlling the fundamental mechanisms underlying the growth and the dynamics of nanoparticles in the gas phase by characterizing cluster beams with optical methods.-integrating two different and complementary methodological approaches (aerosol and cluster beams), under precise on-line monitoring, to attain a fundamental understanding of the mechanisms of production, modification, manipulation of nanoparticles in the gas phase.Long term innovation will be promoted by the development and implementation of a ground-breaking enabling technology based on gas phase nanoparticle integration in different manufacturing processes that are necessary for a wide range of industries in the product manufactu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Decision SupporT and self-mAnagement system for stRoke survivoRs' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Stroke a leading cause of death and disability, with an estimated total cost of €65 billion per year in Europe. Even though preventive measures are in place to reduce the incidence of stroke, the number of persons having a stroke in Europe is likely to increase from 1.1 million/year in 2000 to more than 1.5 million/year in 2025 because of the increasing ageing population. Secondary stroke carries with it a greater risk than first-ever stroke for death and disability. Also, as mortality from first strokes has decreased recently, the number of people at risk for a secondary stroke has increased, with an associated increase in healthcare costs. In order to reduce these stroke statistics and the associated cost, the self-management of stroke risk factors is particularly suitable and necessary for the following reasons: 1) risk factors for stroke are well-known, and 2) 90% of strokes or secondary stroke events are preventable if the risk factors are managed appropriately. The Decision SupporT and self-mAnagement system for stRoke survivoRs (STARR) project and the system developed in it are targeting the self-management of stroke risk factors. Based on existing computational predictive models of stroke risk, we will develop a modular, affordable, and easy-to-use system, which will inform stroke survivors about the relation between their daily activities (e.g., medication intake, physical and cognitive exercises, diet, social contacts) and the risk of having a secondary stroke. This will lead to better prevention and a reduction of the number of secondary stroke events, as well as to a more efficient participation of patients in medical decision-making. A multidisciplinary consortium has been built for achieving the objectives of this ambitious project, involving stroke surviv