RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improved CarbOn cycle represeNtation through multi-sCale models and Earth obseRvation for Terrestrial ecOsystems' (CONCERTO) targeting Horizon Europe.

assistant: **Abstract**

Earth system models (ESM) show diverging estimates of ecosystem carbon (C) uptake which drives persistent uncertainty about future climate and limits the realization of policy mitigation goals. The CONCERTO project aims to strengthen the European research ecosystem by creating an innovative scientific collaborative framework that enhances our understanding, monitoring, and modelling of the terrestrial cycle (CC), and leads to reduced uncertainty and ESM convergence. This framework has three main elements: the exploitation of novel Earth Observation (EO) data, the innovation of process models fed by these data, and Data Assimilation (DA) and Machine Learning (ML) techniques. The consortium includes European experts and institutes active in these areas.CONCERTO will advance the representation of land cover, leaf area index (LAI) and management intensity through new maps of high resolution with layers relevant for the CC. The new management map will enhance the creation of a new biomass production map. Further, CONCERTO will prepare for the ingestion of FLEX data in land surface models (LSM) through DA, and exploit Sentinel-5P/TROPOMI HCHO indicative of biogenic volatile organic compound (VOC) emissions. As step towards moving away from prior (static) parameterizations, the novel P model will be used to ingest these new data sources. This will enhance understanding of ecosystems responses to climate extremes, fires, and vegetation recovery from them, and the parameterization of LSMs included in ESMs. Novel representations of the underrepresented processes of lateral carbon fluxes through outgassing of CO2 from rivers will be developed. Dedicated seasonal and climate experiments will demonstrate how improved representation of land surface processes benefit the accuracy and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cardiac Origin of Rhythm DISturbances: 3-Dimensional structural investigations' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Myocardial structure is important in the triggering and maintenance of many cardiac arrhythmias including atrial and ventricular fibrillation. Detailed knowledge of myocardial structure is essential to the understanding of these disorders and in the development of diagnostic and therapeutic strategies. This must include the normal and pathological distribution of key functional proteins such as connexins. There are a variety of structural imaging methodologies which can be used to study normal and pathological hearts: high spatial resolution MRI and CT, Diffusion Tensor MRI, three-dimensional volume histology from sections or from tissue block imaging. Furthermore, histological imaging can determine molecular distributions after labelling, which may be by immunohistochemistry, viral transfection or transgenics. In this exchange partnership we will bring together four leading centres with unique and complementary expertise in order to systematically study the structural substrate of propagation and arrhythmia in the normal and failing heart and in heart failure. Arrhythmias studied will be the role of Purkinje Fibres in ventricular fibrillation, pulmonary venous cuff re-entry in atrial fibrillation, the role of structural changes in myocardial infarction in ventricular fibrillation and right ventricular outflow tract ventricular tachycardia. Tissue studied will include hearts from relevant animal disease models, post-mortem/operative human tissues. Disease models studied will include small and large animal (rat/sheep & pig) models of infarction and right heart failure. Rat models have the advantage that the small cardiac size allows high spatial resolution imaging to be carried out of the whole cardiac volume, while the large animal models have structure and electrophysi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Short pulse high intensity laser plasma interactions'.

assistant: **Objectives**

Research objectives and content This proJect involves providing theoretical support to the experimental programme at Grupo de Lasers e Plasmas (GoLP) at IST and contributing to their existing theoretical programme. This will involve the development of a new code which will include an electron interaction model and the photon kinetic model developed at GoLP as well as the use of codes and models which have already been developed at Imperial College. The new code will be used to study electron acceleration, an experimental programme on this at GoLP is already planned. It will also give me a chance to become more directly involved in experimental work. Development of theoretical work on photon and electron transport will also be carried out. Training content (objective, benefit and expected impact) This project will provide training in the physics of laser propagation in plasmas, laser plasma electron acceleration and experimental techniques. It will also provide the opportunity to extend work on electron transport already carried out. The training in laser propagation will complement my knowledge on electron transport in laser plasmas. The experimental experience will lead to a better understanding of experimental techniques, of what information is required from computer models and how to interpret and critically review experimental results Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Isotopes of micronutrients to trace margin sediment fluxes'.

assistant: **Innovation**

Copper (Cu), nickel (Ni), and zinc (Zn) are essential micronutrients for phytoplankton growth and directly influence the biological carbon pump, which sequesters about 10 billion tons of carbon per year, thereby limiting climate warming. Although intrinsically linked with the oceanic carbon cycle, their marine biogeochemical cycles are not fully understood. The role of oceanic margins, which modulate the transfer of these trace metals (TMs) between land and ocean, is critically under-constrained. The overarching objective of IsoMargin is to characterise and quantify the fluxes of micronutrients from the sediments at the margins. I will contribute to this effort by using a novel multiple-metal concentration and isotope system (Cu, Ni, Zn) on dissolved and particulate phases (suspended particles and marine sediment) using both field and experimental approaches. The oceanic behaviours of these three TMs are distinct enough to respond differently to specific processes, generating complementary information. Hosted by the CNRS-LEGOS, I will produce the first database of Cu, Ni, Zn concentrations and isotope compositions in both dissolved and particulate phases above and off two margins of the Indian Ocean. These observations will be completed by new measurements of TM isotope signatures induced by sediment dissolution in controlled experiments. The experimental data will be integrated into a thermodynamic model, allowing a better description of the transfer mechanisms between the sediment and dissolved pools and thus a broader application of my findings. This project is in line with the Horizon Europe programme priority exploring and forecasting the impacts of climate change and the GEOTRACES programme. My close involvement in the leadership and management of this project wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Construction and modes of expression of differences in collective action of Afro-Americans and Latinos in a California barrio. Two case studies: One East Palo Alto and San Francis of Assisi' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

GENIDMOV is based on studies of ""unlikely mobilizations"" that are emerging increasingly in a context of global economic crisis and growing social inequality. It focuses on the empowerment process of minority groups (Blacks and Latinos) through their collective action, on the main processes and specific factors allow them to participate in public space. It covers a difficult research field, a barrio in North California (East Palo Alto), taken as a mirror of collective action for “low resources” people, which apparently combine all obstacles to mobilization.The objective of this research is to generate knowledge about obstacles and needs for opportunity enhancement for economic, social and political integration of minority groups and women in a life-course perspective, by examining the influence of the identities of gender, class,race, and of ethnic capital on the forms taken by collective action.It would allow to identify the critical issues in order to conduct appropriate policies of diversity and social equality in the future.Taking advantage of the diverse areas of expertise and of an another context for testing research hypothesis, the purpose is not to limit ourselves to the presentation of the social mechanisms of a phenomenon that affects a particular population, but to take this object of study as an entry feature for renewing the great questions of sociology and political science, such as various forms of social and political participation of individuals, the multiple modes of political socialization, the ways of the politicization of public causes and the elements that define a democratic society and social changes.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A new treatment for acid waters deriving from olive squeezing' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The research project submitted aims to develop a new treatment which exploits biological and chimical methods, as well as electrochimical oxidization process in order to avoid damages deriving from the shedding on land and sea of the acid waters deriving from olive squeezing. The proposal will combine the following three treatments: n.1 mills acid waters will be treated and recicled by biological and chemical methods n.2 inertization of the treated waters n.3 electrochimical oxidization and waste disposal at the end of each phase, there will be a check about the result of the treatment. The three methods will allow to eliminate wastes and create recycled raw materials. This method will allow to reach the following objectives: - eliminate oil mills waste waters which burns vegetations and kill sea life - produce organic materials and gas which could be used in other industries - reduce the cost of agricultural waste disposal in terms of money and time spent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chemogenomic profiling of drug-protein binding by shape, enthalpy/entropy and interaction kinetics' (DRUGPROFILBIND).

assistant: **Concept**

Once a new drug target is discovered, screening techniques are applied to detect prospective hits. However, which hit should be taken to the next level of development? This decision is most crucial as it entails huge financial commitments of the subsequent drug optimization. In consequence drugs are only developed against diseases that promise short-term profit. Chemogenomic profiling allows to compile parameters characterizing binding of drug candidates that achieve optimal interference with protein function. Membrane proteins demand different properties than viral ones. Either high isoform selectivity, promiscuous family-wide binding or efficient resistance tolerance is desired. This calls for very different ligand binding characteristics, requiring either enthalpy-/entropy-driven binding, rigid shape complementarity or pronounced residual mobility at the binding site. Interaction kinetics determine on/off-rates and the time a drug spends with its target. Their correct adjustment is essential for drug efficacy. At present chemogenomic binding parameters are rarely available and their correlation with the required target properties is hardly understood. We want to compile a knowledge base from congeneric protein-ligand series to correlate structural, thermodynamic, interaction-kinetic and dynamic behaviour to predict the qualities a lead must meet to optimally address a target. Our studies involve crystal structure analyses, microcalorimetry, molecular dynamics simulations, site-directed mutagenesis and interaction kinetics. This provides a comprehensive picture to productively change our current understanding of drug-protein binding to move from a current trial-and-error to a more efficient rational approach. It provides the opportunity to also consider orphan drugs a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of the next generation bioreactor system'.

assistant: **Objectives**

Membrane bioreactor (MBR) technology is regarded as key element of advanced wastewater reclamation and reuse schemes and can considerably contribute to sustainable water management. MBR technology is used for wastewater treatment and reuse in municipal, agricultural and a variety of industrial sectors in Europe and MENA. The market pull, in the context of this NMP call, is the increasing demand for clean water complying with the strict European and MENA regulations. The European growing MBR market is dominated by two suppliers from Canada and Japan. Although, the European scientific community is strong in R&D, its expertise remains fragmented and lacks organization and communication within Europe. Despite the fact that the technical feasibility of this technology has been demonstrated through a large number of small and large scale applications, membrane fouling is regarded as an important bottleneck for further development. It is the main limitation to faster development of this process, particularly when it leads to flux losses that cleaning cannot restore. The objective of the BioNexGen project is therefore to develop a new class of functional low fouling membranes for membrane bioreactor technology with high and constant water flux (25 l/m2/h) and high rejection of organic pollutants with low molecular weight (down to 300 Da). The consortium consisting of European and MENA partners will develop a novel single step NF MBR operated with low energy consumption due to less aeration needed (0.2 Nm3/m2/h). Small footprint, flexible design, and automated operation make it ideal for localized, decentralized wastewater treatment and recycling in the European and MENA countries. Successful delivery will have a major impact on the competitiveness of the SME partners in the pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Suicide vaccines against animal herpesviruses: Bovine herpesvirus type 1 as a model' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Development of a novel strategy of vaccination against bovine herpesvirus 1 based on a suicide vaccine, which is able to perform only a single cycle of replication after intranasal inoculation. The vaccine combines the high immunogenic potential of a live vaccine and the safety of a killed vaccine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Therapeutic Beta-Lactam Monitoring for Stratified Treatment of hospital-acquired pneumonia, improved dose-dependent efficacy, decreased treatment duration, and prevention of emergence of resistance'.

assistant: **Objectives**

Stratified clinical treatment interventions meeting patient-specific efficacy (pharmacodynamics) while at the same time lowering the risk of emergence of drug resistance (EDR) and minimizing adverse effects are particularly needed in Hospital-acquired and Ventilator-Associated pneumonia [HAP/VAP] where morbidity, mortality and health care costs remain high. β-lactam antibiotics are at the cornerstone of most effective treatments of HAP/VAP, but dosage adaptations remain difficult because available models (i) focus mainly on efficacy (neglecting EDR and dose-related side effects) and (ii) are derived from population data which imperfectly fit individual patient’s needs due to large, rapid and difficult-to-predict variations of blood levels.Current methods for monitoring β-lactam blood levels are slow and require complex instruments not usable at bed-side.  Yet, generating easily, rapidly and cost-effectively real data usable at the patient’s bed-side should improve outcomes of β-lactam treatments. This is what 3 out of the 11 partners of the MON4STRAT consortium have recently developed (patent pending).Thus the objective of the Project is to integrate both (i) state-of-the-art PK/PD and EDR profiles AND (ii) real-time/patient-specific free β-lactam blood levels monitored at the patient’s bed-side according to the patented assay for developing and implementing a new approach to (i) stratify the HAP/VAP patients according to their specific response, (ii) to propose immediately applicable dose adjustments during treatment and thus (iii) to improve efficacy while reducing risk of EDR or adverse effects.The MON4STRAT approach will be validated through a prospective, multicentre, randomized clinical trial with150 adults. Its applicability in paediatrics will be tested through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biofuels from Solid Wastes' in the context of a Seventh Framework call.

assistant: **Objectives**

The proposed project consisted of three parts. Various types of lignocellulosic biomasses and common used plastics will be used for production of fuels. In the first part, production of bio-oil from lignocellulosic biomasses will be carried out by one-step and two-step pyrolysis systems. The commercial and labor made catalysts will be used in two-step pyrolysis. For each selected lignocellulosic biomasses, the variance of the composition of bio-oil obtained from pyrolysis will be characterized from the point of the composition and fuel characteristics. In the second part, mixtures containing biomasses and plastic materials of different origin will thermally degraded in order to obtain valuable products such as gases, liquids or carbonaceous residue. Various methods (one-step or two-steps processes) and catalysts will be tested to increase the quality of degradation products from biomass/plastic mixtures. The composition and properties of the upgraded degradation products will be determined to identify their possible utilization. In the last part of proposed project a detailed investigation of catalytic gasification of biomass/plastics and biomass-derived tar will be performed using steam as a gasification agent in the temperature range of 600-900 ºC. Iron-oxide (in-lab-made) and dolomite and red-mud will be used as catalysts. The products of gasification will be characterized with GC-TCD, GC-FID and GC-MS. As conclusion, this project brings together a very strong team proposing solutions to energy and environmental problems. The different techniques for production of bio-fuel and chemicals from biomass and plastic wastes as renewable sources will be investigated. Bio-fuel (gas or liquid) will help to meet the government target for bio-fuel production (EC Directive 2003/