RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Directed Colloidal Structure at the Meso-Scale' in the context of a Horizon 2020 call.

assistant: **Objectives**

Fluid dispersions containing highly elongated colloidal particles form a plethora of ordered, liquid-crystalline states as well as glassy and gel-like disordered states already at very low concentrations. In spite of their remarkable properties, industrial applications of such dispersions have entered the market only relatively recently, in contrast to more conventional low-molecular-weight, liquid-crystalline fluids for which the major practical applications are in opto-electronic device technology, e.g., in displays, optical imaging and smart glass. Important potential applications of colloidal liquid crystals can be found in the manufacturing of high-performance fibres and in fast moving consumer goods, such as foods and home and personal care.  To accelerate their exploitation and market introduction, we seek to push the field in a new, innovative direction where rod-like colloidal particles of a very diverse nature are used to form structures with a well-defined direction: Directed Structure (DiStruc) at the mesoscopic level. Our focus will be on the role of confinement and flow, highly relevant to industrial applications. This will open avenues for a bottom-up, rational design of industrial processes, which is an important step to protect the competitive role of European industries on the global market. At the same time, scientifically novel physical phenomena will be explored protecting the leading role of Europe in the field of soft condensed matter. Importantly, it provides a training ground for the next generation of European researchers, unique in its interdisciplinary scope, covering physics, chemistry, biology, materials and engineering, its depth, creating a mind-set where experiments, theory and computer simulations go hand-in-hand, and its focus on the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Electrodermal Orienting Reactivity-based Safeguard System for Early Detection of Suicide Propensity'.

assistant: **Concept**

According to the World Health Organization there are 800,000 suicides and 10 million attempts yearly. Appallingly, suicide is the third cause of death among 15-44 years and the second in 15-29 years old.Suicide is a major burden to society emotionally, but also economically. Costs incurred by each attempt rise to €100,000. Half reduction in the number of attempts would save €20 billion to the EU alone.Depression is the disorder most commonly attributed to suicide affecting 350 M people. Antidepressants are commonly prescribed, but they prove to be insufficient if the patient is at risk of committing suicide. However, there are no reliable tests so far to distinguish depressed patients not-at-risk, from those actually at-risk of committing suicide.In response, the Swedish company EMOTRA has developed EDOR-BOX, an innovative biomarker-based device for early detection of suicide risk. Our technology analyzes brain reactivity expressed as sweat impulses when exposed to audio signals. Absent brain responses are reflected in electrodermal hyporeactivity (no electrodermal responses), which we use as a biomarker for suicide risk in depressed patients.EDOR's main objective is to market a unique tool for effective diagnosis of suicide risk in patients from all age groups. We have already demonstrated the safety and efficacy of our device in adults, with 97% sensitivity in clinical trials. Now we aim to ensure its applicability in youngsters, due to the alarming suicide rates in this population.Our method is a cost-effective solution to prevent suicide by ensuring early detection of the risk. EDOR-BOX will provide estimated revenues of €17 M five years upon introduction, with a global impact and the creation of 50 new jobs. Ultimately, EDOR-BOX will overcome the limitations in our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Breakthrough Solutions for the Sustainable Harvesting and Processing of Deep Sea Polymetallic Nodules' (2014-2020).

assistant: **Innovation**

A key EU policy aims to reduce the Union dependency on raw materials imports, in particular (candidate) Critical Raw Materials that are vital for the EU innovative technologies. Topic SC5-11c-2015 scope focuses on “developing new highly-automated technological sustainable solutions for deep mining … in the sea bed combined with in-situ processing of minerals”. An existing but challenging raw material resource concerns polymetallic nodules. These round to elongated concretions of 1–15 cm diameter form on sediment-covered deep-sea plains in all oceans between 4-6000m water depth. The challenge to harvest and transport the nodules to the EU shore is taken on by Blue Nodules. The governing project principle is: industrial viability within the context of a realistic and technical, economic and environmentally balanced business case for the complete Polymetallic Nodules value chain of mining, processing and valorisation. Blue Nodules will develop and test to TRL6 maturity a new highly-automated and technologically sustainable deep sea mining system. Key features are: an annual production capability of 2 Million Tons nodules in water depths up to 6000m, in-situ processing of the nodules and intrinsic safe working conditions. Technical WPs are dedicated to subsea harvesting equipment & control technology, in-situ seafloor processing of polymetallic nodules and sea surface, land operations & processes. A dedicated WP focuses on environmental issues and on an Environmental Impact Assessment (EIA). A WP setting requirements and assessing the developed technology controls the entire work plan structure. High credibility is obtained by linking the project work to a nodule field licence owned by a project partner and located in the most promising known nodule deposit: the Clarion Cli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Mechanistic study of gut microbial biotransformation reactions and their physiological role.'.

assistant: **Innovation**

The human gut microbiota, the trillions of microbes inhabiting our gastrointestinal tract, encodes an enormous number of metabolic enzymes, responsible for diverse biochemical reactions that determine metabolic microbiota-host interactions. Bacterial biotransformation reactions, the chemical modification of compounds by bacteria, seem to play a central role in such metabolic interplay between the gut microbiota and its human host. A number of gut microbial biotransformations such as reductive and hydrolytic reactions, as well as their metabolic enzymes, have been recently described. The natural roles of these biotransformation pathways in bacterial metabolism and their influence on host physiology have been associated with gut bacterial fitness, nutrition uptake, immune signaling, as well as personal drug response and toxicity. Despite these important functions, our mechanistic and physiological understanding remains still limited for many gut microbial biotransformation reactions, such as chemical conjugation. To fill this knowledge gap, I present a multidisciplinary plan to systematically investigate conjugative biotransformation reactions of gut bacteria.  I will develop mass spectrometry-based methods to identify gut bacterial species and strains that perform conjugative biotransformations, employ high-throughput gut bacterial genetics to identify the responsible genes, determine their role in bacterial metabolism, and eventually assess selected examples for their impact on microbiota-host interactions in gnotobiotic mouse models. If successful, this project will provide novel insights into gut microbial metabolism, and pave new ways to develop strategies for the rational manipulation of gut microbial community functions for better health outcomes. Furthermore, this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural Visualization of Medieval Manuscripts' (StruViMan).

assistant: **Concept**

In the 21st-century world of manuscript studies there is a gold rush for digitalization. More and more medieval manuscripts are becoming available in digital format. This opens up entirely new vistas of understanding both for the interested public and for academic research. However, the availability of digitized images is not sufficient in itself, because a medieval manuscript is more than just a series of pictures. In order to understand its diachronic dimension (its development over the centuries) and its cultural meaning (its texts and images), a deeper analysis is required. At the present stage there is a gap between the world of digitized images (with ever more sophisticated viewers) and the rather conventional metadata (where methodology also becomes increasingly sophisticated). Metadata are usually gathered in printed catalogues; today they are sometimes made available online along with the digital image.StruViMan is a software tool that aims at bridging this gap. Existing metadata can be analyzed and visualized digitally. It will be possible to see a manuscript’s macro-structure at a single glance, including its materiality and its historical development. Likewise, it will be possible to reconstruct entire manuscripts virtually, where they are fragmentary today. With the help of this new tool it will be easier to answer questions such as the following: How many texts and miniatures does a manuscript contain and how are they distributed? What is the relationship between texts and paratexts (such as introductions, tables of contents, colophons, possessors’ notes, etc.)? How did the manuscript in its present shape (its library “shelf unit”) grow over time? What did a manuscript look like when it was whole (before being divided up and having its parts taken to diffe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Electrodynamic Tether Technology for Passive Consumable-less Deorbit Kit'.

assistant: **Concept**

The Low Work-function Tether (LWT) is a long conductive tape coated with a material that enhances thermionic and photoelectric electron emissions. It enables spacecraft to de-orbit and/or re-boost without the need for consumables. It interacts passively with its environment (ambient plasma, magnetic field and solar radiation) to exchange momentum with the planet’s magnetosphere. E.T.PACK aims at developing a proof of concept for LWTs by breaking through and combining the current frontier of knowledge in three fields: plasma physics, low work function material science and space tethers. These will be integrated into a deorbit kit and a flight simulator for mission analysis. The kit aims to reach Technology Readiness Level 4 and will have two modes of operation: as a fully passive LWT and as a conventional electrodynamic tether equipped with an active hollow-cathode (backup mode). A new coating process for the electride, C12A7 ([Ca24Al28O64]4+(4e-)), will be developed, and used to manufacture a LWT demonstrator. The C12A7 and its extraordinary properties will be also applied to the hollow cathode of the kit, which will include a novel deployment mechanism specifically designed for LWT applications. The complex current exchange of LWTs with the ambient plasma under space-charge-conditions will be studied theoretically, and used to develop accurate simulators. The theory-experiment comparisons will lead to a solid framework for LWT operation and constraints, including thermal, mechanical, optical, electrical, ATOX and UV resistance, and survivability. Hitherto impossible mission scenarios will be explored, thus opening up new horizons in space science and technology. These interdisciplinary activities, placed at the cutting edge of their fields and highly interdependent, ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SACCSCAN - personalising clinical management of major psychiatric disorders' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

1 in 5 of us experience mental health problems during our lifetime but more than 50% of patients don’t receive adequate care. Currently, when patients’ symptoms and behaviour don’t meet the criteria set out in the diagnostic manual, it may take up to 10 years to diagnose the illness. Delays in receiving a diagnosis can significantly impede delivery of the most effective treatment plan, exposing the patient to risk of further deterioration in well-being, reduction in quality of life leading to job loss, family breakdown, and self-harming. Mental ill health is now recognised as the largest cause of short and long term disability worldwide costing the global economy US$2.5T with a projected increase to over US$6T by 2030. SaccScan is a novel point-of-care (PoC) software diagnostic system which has been demonstrated to detect schizophrenia with better than 95% accuracy and has been extended with the same precision to bipolar disorder and major depression illnesses. The software diagnostic tool successfully utilises eye-movement abnormalities as clinical diagnostic biomarkers for serious mental illnesses. The test can be performed within 30 minutes and results produced over the internet at near real-time speed. Early economic modelling showed that introducing SaccScan into health care services could produce savings of €33 474 per patient in the case of suspected schizophrenia. The global market for this test is in excess of €5 billion with early-adopter customer segments making up over 10% of the total market - creating a potential initial market share of €100 million per annum. The purpose of this Phase 1 application is to demonstrate proof of business and develop the necessary partnerships for bringing a minimum viable version to market. Further support from H2020 SME Inst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Testing the limits and potential of evolution in response to climate change' (CLIMADAPT), addressing dissemination and exploitation.

assistant: **Impact**

BACKGROUND:  Predicting the consequences of rapid environmental change for biodiversity is a critical global issue. However, we lack data on how quickly populations will evolve to escape extinction. Such evolution is especially important to specialist organisms that depend on other species as hosts or prey. Understanding limits to adaptation depends on knowing how genetic variation affects the fitness of organisms in natural habitats rather than the lab. Recent advances in genomic technology finally make this possible.OBJECTIVE: I will exploit these novel technologies and integrate them with fitness assays in ecological experiments to explore recent evolution in the Brown Argus butterfly. By linking genome-wide variation with individual fitness and population ecology, I will investigate the nature of genetic variation underpinning ecologically important traits such as host plant preference and fecundity, and the role this variation plays in shaping adaptive population divergence across the northward expanding range in the UK.STRATEGY:  My research and training will be guided by world-leading researchers with expertise in: evolution at species’ margins; the generation and analysis of large-scale genomic data; and using such data to infer the ecological context in which evolution occurred. This fellowship will take the Brown Argus system forward as a model to study adaptation to climate change. The impact of my research on policy will be maximised by exposure to Bristol’s world-class environment for engagement with industry and the publicLONG-TERM RELEVANCE:  Developing expertise in genomics is critical to take my science forward; researchers with such skills are also in high demand. Expert mentoring at Bristol will boost my development as an independent PI, placing me in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Flow physics modelling-an integrated approach (FLOMANIA)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Primary objective of the FLOMANIA project is to provide the Europe. Aerospace Industry with a mechanism to exploit substantial advances made on the research side in the area of modeling and simulating turbulent aerodynamic flows. This is the key towards reliable integration of CFD into multidisciplinary methods and involves:1 . Establish of reliability , robustness and accurate knowledge of the limitations of currently used algebraic, one and two equation, eddy viscosity, models.2. Generate the validated integration of new non-linear and EARSM models in industrial aerodynamic CFD codes and, as the major aim, generate the validated integration of full DSM models in industrial codes.3. Extend these implementations to the new generation of unstructured solvers, including the analysis of their impact on adaptivity.4. Create the industrial transition process towards DES, representative of the next generation of turbulence modeling.5. Establish the limits of validity of various model generation for industrial applications6. Ensure a high level of focused technology transfer in implementation strategies of turbulence models into the industrial codes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanotube Based Polymer Optoelectronics' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The target of this project is to develop a new class of polymer based optoelectronic devices embedding the optical and electronic functionalities of carbon nanotubes (CNTs). These devices will combine the fabrication advantages of polymer photonics, with the tunable active and passive optical properties of CNTs. This is an ambitious frontier research program, with a strong interdisciplinary nature, across engineering, physical, chemical and soft matter sciences. The ERC grant will consolidate the newly funded Research Group lead by the PI at the newly built centre for Advanced Photonics and Electronics of the University of Cambridge. CNTs will be grown by chemical vapour deposition at low temperatures, compatible with polymer processing. Direct deposition of CNT on optical components (such as fibres and mirrors) will be studied. Fundamental understanding of ultra-fast non-linear optics will be sought by a combination of theory and experiments. A range of novel photonic polymers incorporating CNTs will be produced: index matching gels, optical adhesives and silicones. These new materials, incorporating the optical functionality of CNTs, will be used to build a variety of photonic devices. Nanowires are also promising for photonic applications, since they exhibit a size-tunable absorption resonance at telecommunications wavelengths, and their use will also be considered.