RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular basis of cell communication during a migratory event that establishes brain asymmetry in zebrafish' (CCMEBAZ) targeting Seventh Framework.

assistant: **Abstract**

The long-term aim of the proposed study is to resolve the genetic and cell biological mechanisms that contribute to the establishment of vertebrate brain asymmetry. In the zebrafish forebrain, an event crucial in establishing and elaborating asymmetry is the migration of the parapineal primordium. Parapineal cells are specified bilaterally at the midline. They subsequently assemble into a rosette-like structure and migrate to the left side of the brain. The molecular basis of the cellular communication among the parapineal cells during migration is still poorly understood. Preliminary data in Dr Wilson’s group show that Fgf8 induces highly focal pathway activation prior to and during migration. Fgf-reporter activation is found only in one or a few cells that are likely at the leading edge of the migrating primordium. This reporter activation occurs concurrently with suppression of activity in adjacent cells. Our hypothesis is that Fgf pathway activation non-autonomously suppresses pathway activity in neighbouring cells thereby establishing polarity within the entire primordium. In the proposed project, I will utilise multiple techniques to address specific questions with the following immediate aims: 1) to establish how localised activation of Fgf signalling correlates with parapineal migration; 2) to determine how Fgf pathway activation non-autonomously regulates pathway activity in neighbouring cells by addressing the roles of candidate interacting pathways (Notch and Wnt); 3) to determine the molecular mechanisms that govern the cross-talk between Fgf signalling and any of the identified candidates in aim 2.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The relationship between sectoral policies and agricultural water u se in Mediterranean countries'.

assistant: **Objectives**

This project seeks to contribute to the sustainable management of water resources in Mediterranean countries through integrated, multi-disciplinary planning. First, the project aims to identify the policy factors that encourage farmers to use large quantities of water, then to evaluate the technical and economical feasibility of decreasing agricultural water demand. Finally, the project will attempt to identify the policy factors that could be modified to this end in a range of sectors.More specifically, the study will embark on the following tasks :* Investigate the full range of sectoral policies (e.g. agriculture, energy, industry) which directly or indirectly influence agricultural water demand in seven Mediterranean countries.* Prepare a series of horizontal" studies analysing salient sub-themes related to policy and agricultural water use. These studies will refer to the Mediterranean basin as a whole.* Assess the feasibility of introducing policy modifications to decrease the consumption of water in the agricultural sector. These analyses will specifically examine the impediments to such change and the possible collateral impacts on environmental and socio-economic factors.* Provide results and tools which allow European, national and regional policy-makers to take concrete steps towards sustainable water management in the agricultural sector.* Promote the use of inter-disciplinary approaches to problem-solving and regional collaboration.Expected OutcomeThe final project report will include an integrated picture of the possibilities for introducing improved practices through policy changes. It will compare the results and conclusions of the individual systemic, thematic and prospective analyses. It will also provide a methodological framework for follow-up and as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development and demonstration of compact, multi-source heat eXchanger technologies for renewable energy applications' (RENEWX).

assistant: **Concept**

Europe's refrigeration, air conditioning and heat pump industry has an annual turnover of €30 billion and employs around 200,000 people. Within this industry our SME Associations represent over 1,000 SMEs within the heat pump manufacture, solar thermal system manufacture, design and installation sectors. Led by these associations the HeatXchange consortium consists of European SME associations, SME end users and some of Europe’s leading research associations. Together, we are proposing to develop new platform technologies that are relevant to our industries and their markets across Europe. The HeatXchange project will provide European manufacturers with alternative designs and manufacturing routes that will assist them expand their product range and to effectively compete with non-European competition. This will be achieved through the development and demonstration of a novel heat exchanger technology and manufacturing process that will enable increased market penetration of European-made air source type heat pump systems. The new platform technology will improve the efficiency and reduce the size of the evaporator, whilst enabling the integration of secondary or even tertiary energy sources. Overall these advanced will enable significant increases in Seasonal Performance Factors (SPF) which will improve the return on investment for consumers and hence attractiveness of EU air based heat pump systems. During the project this technology will be disseminated amongst our 1,000 members within the industry and showcased at events and conferences. Our aim is for HeatXchange to increase air-based heat pump sales by European manufacturers by at least 100,000 across Europe between 2014-2020 adding €300 million of value to Europe’s economy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'How to grow a flat leaf?' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Growing flat leaves is crucial for plant success, since it directly affects light interception and photosynthesis. This process is tightly regulated by endogenous signals revealing a strongly genetically defined developmental program, but is also modulated by the light environment. As shown using null mutants, both blue light receptors phototropins (phot) and red/far-red light receptor phytochromeB (phyB) affect leaf flattening, and it was recently found that plants lacking PKS3, a protein involved in phot signaling, suffer severe flattening defects. The main objective of this project is thus to determine how light signals interact with endogenous cues to control development of a flat leaf. First, I will perform an exhaustive temporal and spatial characterization of the phot and phyB-mediated light control of leaf development applying various light treatments and complementing phot1phot2, phyB and pks3 with tissue-specific promoters. Next, I will apply the latest microscopy techniques to determine the expression pattern of leaf development markers under various light conditions and in photoreceptor mutant backgrounds. Also, given the major role of auxin in leaf development, and the various ways in which phot and phyB control it, I will study auxin abundance, transport and sensitivity at the tissue and cellular level. Finally, I expect to identify new components of phot signaling evaluating the interactome of PKS3 through IP-MS. Thereby I expect to determine how a conserved developmental program and photosensory cues crosstalk to control leaf flattening.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Precursors of ozone and their effects in the troposphere' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Problems to be solvedTropospheric ozone has a dual role with respect to climatic changes. Ozone is itself a greenhouse gas and it also plays a key role in the production of the hydroxyl radical (OH), which controls the lifetime of many climatically important tropospheric gases. Tropospheric ozone and OH are produced as a result of photochemical processes, through reactions involving ozone precursors. The proposed project is defined in order to answer three main questions:first, can the surface emissions of ozone precursors, and their variability be accurately quantified?Second, how should the current observations of chemical species be optimally coupled with chemistry-transport models (CTMs) to quantify the global budgets of ozone precursors and ozone?Third, how do future changes in surface emissions and proposed future scenarios influence the lifetime of greenhouse gases and ozone distribution?The project will provide a quantitative basis for emissions, distributions and evolution of chemical tropospheric species for discussions related to policies aimed at improving the quality of air or at reduction of greenhouse species anthropogenic emissions.Scientific objectives and approachThe overall objective of the project is to quantify accurately the budget of ozone precursors using a combination of observations and state of the art CTM. The retrieval methods to derive accurately the tropospheric burdens of CO, CH4, NO2 and ozone from observations provided by the IMG/ADEOS and GOME instruments will be improved. High-resolution inventories of emissions for ozone precursors will be developed. The ability of several European CTMs to reproduce current distributions will be assessed, through detailed comparisons between model results and observations. The impact of changes in oz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fuse-based segmentation design: Avoiding failure propagation in building structures'.

assistant: **Innovation**

Extreme events often cause local-initial damage to the critical elements of building structures, followed by a cascade of further failures in the rest of the building; a phenomenon known as “progressive collapse”. Current design philosophies are based on giving buildings extensive continuity, so that when a critical element fails its load can be re-distributed among the rest of the structure. However, in certain situations (e.g. initial failure of several columns) this extensive continuity introduces undesirable effects and actually increases the risk of progressive collapse.Segmenting a building into individual units connected only by means of fuses would avoid a failure in one zone propagating to others. While such fuses would provide continuity for normal loads or small local-initial failure, they would “isolate” the different parts of the building when otherwise the forces generated by the initial failure would pull down the rest of the structure. Although fuse segmentation is probably the only alternative that can fill the gaps in the present design philosophies, so far, no studies have been carried out on the possibility of applying it to buildings.Endure’s overall aim is to develop a novel fuse-based segmentation design approach to limit or arrest the propagation of failures in building structures subjected to extreme events.The project will be multidisciplinary and highly ambitious, and will achieve its overall aim by: 1) Developing a performance-based approach for the design of fuse-segmented buildings; 2) Designing, manufacturing and testing fuses for segmenting buildings; and 3) Implementing fuses in segmented realistic building prototypes and testing and validating the new fuse-based approach in these structures.Endure will open up a new research area and de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'MEtabolic Cell Reprogramming for the Recovery of Lost INsulin-Producing Cells'.

assistant: **Concept**

My group aims at fostering the regeneration of insulin-producing -cells in the diabetic pancreas by promoting the reprogramming of other islet endocrine non- cells. I will use mice and human islets to trigger the metabolic reprogramming of: i) peripheral organs, in order to reduce hyperglycemia, and ii) human islet non--cells, to induce their acquisition of insulin secretion.I developed transgenics to elicit total (>99%) or graded (5-90%) -cell loss. These mice revealed that non--cells, which produce other hormones, can naturally switch to insulin production upon -cell loss, and lead to diabetes recovery. My group recently showed that human non--cells, from healthy or diabetic donors, also display plasticity and can engage in regulated insulin secretion. What metabolic adaptations occur in peripheral organs in response to insulin deficiency, but without complications? Can metabolic reprogramming of peripheral organs, based on these adaptations, suffice to control glycemia? Can metabolic reprogramming change the identity of a cell? Natural recovery of euglycemia after -cell loss is documented in mice. To know the mechanisms driving relief, my lab will characterize islet cell dynamics and circulating molecules (metabolites, RNA, peptides) after various degrees of -cell loss. We will perform a full analysis of blood and peripheral organs in recovered mice, and an array of genetic and pharmacological experiments modulating BAT mass and function to test its role in taming hyperglycemia.We will explore and define the metabolic differences between human - and non--cells. Using monotypic pseudoislets we will do RNAseq, proteomics and metabolomics after exposure to glucose. We will quantify oxygen consumption, extracellular acidification and ATP production in response to nutrien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Strengthening public health policies in health sector reforms in latin america' under Fifth Framework.

assistant: **Concept**

The Concerted Action will analyse policies related to health sector reforms in Latin America and Europe and their impact on public health care in order to share recent experiences and to improve actual policies and their implementation. The analysis of financing aspects, of the policy impact on particular control programmes (vector borne diseases, immunopreventable diseases , tuberculosis ,cardiovascular diseases and other non-communicable diseases)as well as on important principles of health care (such as equity, particularly gender equity) will bemused for developing jointly a tool kit for policy makers. This will strengthen the adequate health care particularly for the poor. European countries will learnfromLatin American experiences and vice versa.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Realising and Managing International Research Infrastructures' (RAMIRI) targeting Seventh Framework.

assistant: **Abstract**

This project builds on recent developments in the management of Research Infrastructures, specifically the publication of the European Strategy Forum on Research Infrastructures (ESFRI) Roadmap and four European conferences which discussed how to develop regional, national and international policy in this area, particularly the legal, financial, operational and governance aspects of managing large and complex research infrastructures. The principal aims of this proposal are to train senior policy makers and scientific decision makers, particularly in New EU Member States and Associated States, in the practical governance and management requirements of pan-European and transnational Research Infrastructures; and to develop a policy framework directed at managing future large Research Infrastructures across national boundaries. Key deliverables of the project will be a symposium entitled ‘Realising and Managing International Research Infrastructures’ which it is proposed to hold in three leading centres of European research – London/Oxfordshire, Grenoble and Hamburg. The project Coordinator will be Imperial College London, which will work closely with its partners, ESRF, ILL, Elettra, DESY and UKAEA-Culham ensuring that the outcomes have the authority and support of leading organisations in this field. Additionally, the symposium will result in a network of experts, delegates and other organisations active or interested in managing RIs. Discussions during the conferences, and afterwards through the network and published preliminary policy paper and Symposium Report, will identify the essential requirements for taking forward the ESFRI Roadmap. The resulting sharing of experience and knowledge will be an essential component of a European strategy for developing and safegua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Novel PUR foaming manufacturing process with reduced toxic isocyanate content'.

assistant: **Innovation**

Polyurethane (PUR) is one of the most versatile materials ever created, present in the cars, under the carpets, as packaging material, cushioning material in almost all furniture and bedding. The European PUR foam sector has 50.000 companies that employ over 1.6 million people.Polyurethane foam technology consists on foam building by reacting two chemicals, isocyanate and polyol, in the presence of other additives such as blowing agents, catalysts, and fire retardants. Manufacture of PUR foam requires certain amount of free isocyanate in order to fully react the polyurethane mixture. Isocyanate component represents a potential risk to workers during manufacture of the PUR foams. Isocyanate is included in the 2003 European schedule of occupational diseases, and it has been established that ten to twenty percent of asthma cases recorded in EU are due to isocyanates.The aim of FREEFOAM is to reduce health risk of workers during foam manufacturing by lowering the concentration of free isocyanate and reducing the emission of the same to the atmosphere. We propose a unique, homogeneous reactive mixture for PUR foaming purposes where reactants are physically separated by using functionalised microcapsules of isocyanate conveniently dispersed on polyol mixture component. The reactive system will allow increasing the mixture reactivity due to the performed compatibility and hence, homogeneity between isocyanate and polyol components while decreasing the exposure of workers to harmful emissions by lowering the residual monomer content on the foam, avoiding the emissions and migration of such components from foams. In addition, the used solution will allow decreasing the generated waste due to bad cell homogeneity and product density as consequence of bad mixing process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dgd 2001' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Advanced research conferences at the European level in genetics will have the effect of exposing young researchers in biology and medicine to the rapid progress that is being made in the fields of clinical dysmorphology and developmental biology. The proposal that the course From developmental genes to dysmorphology" becomes part of the Euroconference network has the precise aim to promote coordinated molecular and clinical studies in Europe, taking advantage of the expertises of excellent scientists in the above-cited fields. The experimental findings that correlate gene expression and function at defined developmental stages and animal models by which the contribution of sets of genes to building organs and tissues is clarified, offer explanations to the pathogenesis of malformations. While the complex pathways that sustain normal human development are being progressively unravelled, it is clear that clinical dysmorphology is moving very fast from a pure descriptive to a molecular discipline. The above statements are reinforced by the possibilities offered by the great amount of information made available thanks to the human genome project, the progress in creation of clinical data bases and classification of diseases, the development of technologies."