RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'BIOactive implantable CApsule for PANcreatic islets immunosuppression free therapy' under Horizon 2020.

assistant: **Concept**

The key therapeutic issue in diabetes mellitus type I and II is glycaemic control. Reductions of constant self-control, of insulin injections, and of long-term complications would have tremendous benefit for quality of life. The best therapy option is the transplantation of allogeneic islet cells, but the current state of the art limits the applicability of this approach. Implanting unprotected grafts requires lifelong administration of immunosuppressants, and protecting the cells against adverse immune reactions by current encapsulation strategies reduces their functionality and survival to an extend that makes frequent ‘refresher’ implantations necessary. Currently, a maximum of 2 years glycaemia regulation has been shown for the encapsulated approach.In BIOCAPAN, bringing experts from different fields all together, we aim at developing an innovative treatment, based on the implantation of allogeneic islet cells that are embedded in a complex microcapsule. We will design a GMP-grade bioactive microcapsule that will maximize the long-term functionality and survival of pancreatic islets by prevention of pericapsular fibrotic overgrowth, in situ oxygenation, innovative extracellular matrix microenvironment reconstruction and immune-system modulation. We will establish a GMP-grade microfluidic microencapsulation platform to protect freshly harvested islets quickly in a standardized and reproducible way.We aim for full preclinical validation and we will establish a complete protocol in accordance with the provisions of the Advanced Therapy Medicinal Products Regulation, in order to start clinical trials within one year after the end of the project. We aim for 5-years insulin injection free treatment, without immunosuppressants, which would tremendously benefit diabetes mel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Stimulation of Multiple Organoids Simultaneously'.

assistant: **Concept**

This project aims to develop STIMOS, an in-vitro platform to simultaneously stimulate and record from multiple mouse or human derived 3D retinal organoids by high-density multi electrode arrays.


**Keywords:** Retina electrophysiology, multielectrode arrays technology, visual restoration, retinal ganglion cells, axons, mouse induced pluripotent stem cell-derived organoids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Time Allocation of Men and Women in India: The Role of Bargaining Power', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Time allocation among household members, across various paid and unpaid activities throughout the day, gets negotiated through individual preferences, gender norms, and the bargaining power of respective individuals. The time allocation across activities by gender, age, and location is associated with Sustainable Development Goal 5 on Gender Equality (Indicator 5.4.1), and the differences in time allocation by gender are linked to the process of economic development of a country. Despite the societal and economic significance, scholarly discourse on time use is until now mainly restricted to developed countries, with a lack of data hampering the analysis of intrahousehold time allocations in developing-country contexts. In this project, I will use Time Use Survey 1998-99 and 2019 data from India, together with the National Family Health Survey II (1998-99) and V (2019-21) data from India to examine the intrahousehold allocation of time across paid and unpaid activities. I will use econometric specifications to examine the variation in paid work, unpaid work (domestic work, care, other unpaid work), leisure, and necessary activities by considering the intersectionality of gender with socio-economic identities, location, and their change over 1998-99 and 2019. In addition, I will explore how various measures of married women’s power – women’s education level relative to their husbands and mothers-in-law, their decision-making autonomy, and freedom of movement outside the house - influence intra-household time allocations across activities. This project moves beyond the narrative of power previously explored in developed countries and examines the forms of power that influences women’s time allocations in a developing-country context. The approach of this project is likely
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multi-actor collaboration dynamics and capacity building network inside and between AKIS to foster the upscaling of SFSCs across Europe' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In line with the new CAP post2020, the F2F Strategy and the Green Deal, the EU4Advice Project will develop enabling methodologies and tools to connect short food supply chains (SFSCs) advisors in a common network with the aim of fostering the upscaling of consumer-producer chains across Europe. SFSCs are a mean for producers to increase their bargaining power and to improve their position within the value chain and for consumers to increase trust, transparency, quality and safety of their food. Political and socio-economic barriers and gaps need to be addressed in order to enhance the scope of consumer-producer chains across Europe and EU4Advice will provide the necessary tools to the relevant stakeholders to overcome them. One key challenge to achieve this goal is to improve national AKIS by implementing new governance models that facilitates the integration of SFSCs advisory servicesThrough a multi-actor approach involving advisors, policy makers, researchers, farmers and consumers, and by implementing a living lab methodology, EU4Advice will create the foundations for the establishment of a network of SFSC-advisors across Europe that will be appropriately structured and connected to a diversity of stakeholders within the national AKIS. The development of networking tools, contents for SFSCs advisors, a tailored dissemination, communication and exploitation strategy, and impact assessment plans will create the appropriate ecosystem for the effective transfer of knowledge among stakeholders in the 27 EU members. Based on previous key related multi-actor projects, EU4Advice will apply the “GAIN transition model” to guide the successful implementation of the multi-actor network through different administrative levels: local, regional, national and European. EU4Advice wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optogenetic Neural stimulation platform' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The 2003 breakthrough discovery of a nanoscale optically active cation channel, channelrhodopsin-2, made it possible for the first time, to genetically re-engineer neuron cells to be photosensitive. It became possible to stimulate or inhibit individual action potentials at will, without further chemical modification. The capabilities have been demonstrated in a number of recent high profile journals detailing optical-neural control from cell culture to primate models. The light-gated cation channels were discovered and first applied by European researchers. The photonics and optoelectronics sectors, which can provide new stimulation technologies to this field, are additionally, European strengths. Nevertheless, in recent years, the dominant research output in this area has shifted to well-funded US laboratories.This proposal therefore aims to create a consortium to develop an array of ultra bright electronically controlled microLEDs which will provide a truly revolutionary tool for the neuroscience and neurotechnology community. The consortium consists of experts in the field who converge the many disciplines (optics, sophisticated LED fabrication, CMOS flip chip design and bonding, biophysics, molecular biology, neurophysiology) to bear on the complex, and crucial to neuroscience, problem of studying dendritic physiology and neural network dynamics. Advances in the techniques of this field will absolutely be required to further our understanding of brain function. The system we propose to develop will be powerful, sophisticated and at the same time, lead to a commercial spin-out that will provide them at relatively low cost. In the longer term, the tools we develop in this proposal will hasten our long term aims of developing an optogenetic retinal prosthesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DNA Repair State Machines' (RepState) targeting Horizon Europe.

assistant: **Abstract**

The Doctoral Network RepState aims to train a new generation of innovative scientists in biochemistry and biophysics to address central questions in biology concerning the mode of action of critical DNA Repair proteins that act as state machines. RepState consists of a highly collaborative consortium consisting of 14 participants coming from academia, industry and the creative sector, representing the natural sciences as well as the social sciences. Participating laboratories in RepState are part of established research schools within renowned research organizations and universities. This environment of excellence offers a multidisciplinary PhD program to 13 young researchers, through training in the fundamental chemical and physical principles that underlie biology and human health. In addition, training will focus on method development using technology and experience provided by the academic participants as well as by the two small technology-driven companies. Training incorporates a local program, rotations within partner laboratories, exposure to the non-academic sector and annual meetings. Fellows will follow scientific workshops, courses in transferable skills and career development, and will disseminate and communicate their projects to a diverse audience in close collaboration with the creative sector. The RepState fellows will form a new generation of mature and innovative European scientists with a thorough understanding of fundamental quantitative principles underlying biology, with experience in technique development, career perspectives in multiple sectors and an understanding of the importance of the role of fundamental science for society and human health.


**Keywords:** DNA mismatch repair, transcription coupled repair, single molecule analysis,  electr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A pseudo binary approach to secondary aerosols' under Sixth Framework.

assistant: **Concept**

The objective of this proposal for is to contribute to strengthen scientific collaboration between European and Mexican scientist working on air pollution. Dr. L. G. Ruiz-Suárez, the applicant to the fellowship is a leading atmospheric chemist in Mexico. There, he is the leader of one of the most active research groups on this subject.His group pioneered work in Mexico on photochemical reactivity and air quality modeling, biogenic VOC emissions and inventories, trace compound analysis in gas phase and particulate matter and GHG emission factors and emission inventories. He proposes to spend a 18 months leave at two top leading European Research facilities.The host site would be CEAM, where Dr. Ruiz-Suárez will test, with EUPHORE data, a SOA model that streamlines calculations. It assumes that the phase distribution of an organic compound can be considered as that compound dissolving at infinite dilution into one pseudo solvent in the suspended phase. The molar properties of that pseudo solvent are the weighted average of all other known compounds in the phase.This approach is iteratively applied to all of those compounds, extracting and replacing them, one at the time. The model his being tested with traditional smog chamber experimental data found in the literature with encouraging results. To learn about state of the art biogenic VOC emission measurements with Dr. R Steinbrecher from IMK-IFU he will join a fieldwork in an EUROFLUX site Tharandter Wald".This continuos flux site over sprucees representative of a forest area of about 60 sqr. km in the eastern Erzgbirge, about 10 km SW of the city of Dresden/Saxony. This site is used for validation of airborne measurements over complex terrain. Dr. Ruiz will learn about and explore the adaptability of the sampling and ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Common Notion. Science and Consensus in the Seventeenth Century' under Horizon Europe.

assistant: **Concept**

NOTCOM is a philosophical study of common notions, collective inquiry, and dissemination strategies in seventeenth-century natural science, with special focus on the role of so-called common notions. Using a ground-breaking transversal methodology, it studies: (1) epistemological models of consensus as they emerged from early modern controversies in logic, rhetoric, moral philosophy, theology and law, and how they were re-deployed within natural philosophy; (2) methods of collective inquiry in early modern natural philosophy; (3) the role of consensus models and methods of collective inquiry in the public dissemination of early modern natural philosophy; (4) the actuality of early modern consensus models and methods of collective inquiry in relation to current philosophy of science and science communication studies. Early modern collective scientific practices have, over the last half century, provided a rich field of study for the sociology and history of philosophy of science. Little attention has, however, been paid to the role that epistemological models of consensus played for the methods governing those practices. Yet the period produced a wealth of such models, often in the context of doctrines of common notions, which informed natural philosophical methods of collective inquiry in myriad ways. These methods were moreover inextricably wound up with complex strategies for the broader public dissemination of science. Some of these, models, methods, and dissemination strategies still have purchase today. More importantly, however, writing their history offers a narrative about philosophy, science, and society with a didactic potential that merits exploration. Combining these four dimensionsconsensus models, collective methods, dissemination strategies, and actuality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Feasibility study of a novel treatment for cancer based on a recombinant peptide therapy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Peptomyc S.L. is an SME created to develop a new, first-in-class, cancer therapy using innovative anti-Myc peptides. Myc is an oncogene deregulated in the majority of human cancers, making Peptomyc’s products potentially applicable to all cancer patients. The recombinant peptides are based on Omomyc, a Myc inhibitor benefiting from 20 years of preclinical validation as gene therapy. Omomyc displays remarkable therapeutic impact in multiple cancer models, with limited side effects, and no emergence of resistance. These peptides (Omomyc-CPP) developed by Peptomyc have unexpected cell-penetrating properties that make them excellent candidates for drug development. Three different drug products are being derived from the same drug substance, based on different administration routes, formulations and delivery devices. Peptomyc’s first mission is to take the first drug product (OMO-101) to completion of a successful phase I/II clinical trial, demonstrating safety and efficacy initially in glioblastoma (GBM) patients. Upon completion of phase I/II, Peptomyc plans to reach a licensing deal with a pharmaceutical company, to take care of further development and commercialization of OMO-101. In the feasibility study proposed here, Peptomyc’s team will elaborate and refine the business development plan of this new therapy to maximize its social and commercial potential. Such study will include:a. Management of the IPR strategy;b. Selection of the best CRO partners for [1] execution of safety studies, [2] clinical trials coordination, [3] Pre-IND and IND applications and other regulatory requirements;c. EMA Briefing meeting; d. Refinement of the business development plan, including market and risk analyses and costs.This feasibility study will be a strong asset to advance this uniqu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New generation of protective coatings alternative to hard chrome', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The total annual estimated direct cost of corrosion, not including wear damage, in the worlds is estimated at about 3.1% of the world’s Gross Domestic Product (GDP). Protective coatings serve to prevent wear and corrosion and thus reduce the total loss from corrosion and wear. Hard chromium plating is one of the most widely used techniques for production of such coatings. However, hard chromium faces many problems: EU restrictions due to use hexavalent chromium, health issues for the plating industry personnel due to cancers events, functional defects of the coatings and low current efficiency. Thus, there is an urgent need to substitute chrome plating with an alternative one that could provide the same or even enhanced benefits that chrome has, without causing the above problems.The target of the project is to eliminate the use of hard chromium plating in European electroplating industry by delivering a suitable alternative, which will be the  nano structured Ni-P and Ni-P composite coatings (with SiC or WC as reinforcing nanoparticles).The successful outcome of the HardAlt project will lead to the restriction or even elimination of the use of hexavalent chromium in electrodeposition industry and will not be subjected in EU legislations. As HardAlt coatings will present equal or even enhanced functional properties compared to hard chrome, they will be adopted by the metal working industry in applications where wear and corrosion resistance is of crucial importance. Significant benefit will be the customization of the HardAlt coatings in the need of each application using the same bath leading to raw materials saving and minimization of wastes from electroplating industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PHYtomanagement as a sustainable feedstock source of lignocellulosic-based high-value BIo-based products for textile applications' to be submitted under Horizon Europe.

assistant: **Abstract**

pHYBi is a 48-month action that will combine the soil phytoremediation concept with lignocellulosic biomass valorisation in an integrated phytomanagement circular economy approach. The pHYBi concept will focus its efforts across different levels of development (1) test, optimisation and validation of 4 phytomanagement case studies, (2) optimisation of biomass fractionation into lignocellulosic components based on organosolv techniques, and (3) characterisation and application of lignocellulosic fractions to create a well-planned market route for the potential end-applications in the textile industry.Furthermore, the project will develop a Virtual Replication Tool where phytomanagement, valorisation process and end-products will be integrated, resulting in guidelines, recommendations and thresholds for the replication of pHYBi’s case studies along other areas. To finalise the proposal concept, social innovation activities will strongly connect the process with the market and society with the aim to deliver high quality products with high level of acceptance.To achieve its goals, pHYBi brings together a multidisciplinary team integrating experts in plant and soil science (UBFC, UBU, UNIOVI, PHY), chemical engineering and biorefineries (CETIM), computational science (IDE), textile materials and products (NTT), agroindustry (PARTICULA, PHY, DIH-LEAF), and market analysis, knowledge exchange and social innovation (SEZ).


**Keywords:** Phytoremediation; Bioremediation; Microorganisms; Lignocellulose