RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel nanomedicine for the treatment of glioma' (EDROMA) under Horizon 2020.

assistant: **Objectives**

Lisapharma, an Italian pharmaceutical SME, aims to bring on the market Edroma: a new product based on a nanotechnology platform to treat malignant high-grade gliomas (HGG), for which there are no satisfactory curative methods. High-grade gliomas are the most aggressive type of brain cancer. Despite recent advances in treatment, the prognosis for patients with HGG is dismal: so far the most effective treatment, radiotherapy, brings an increase in median survival from 3-4 months to around 9-10. The Edroma medicinal product is a dispersion for injection made of nanoparticles encapsulating the active ingredient zoledronic acid, resulting by a self-assembling procedure made possible by Lisapharma’s patented platform. Compared to the current brain-cancer therapy solutions, Edroma innovation brings significant improvements in terms of higher efficacy and lower toxicity. Pre-clinical tests on mice demonstrated tumour reduction, increased life-expectancy and even, in one case out of 6, complete cure. Lisapharma has obtained the orphan designation from both EMA and FDA. This represents a unique business opportunity, as Lisapharma will be the only authorised provider of the new product for 10 year (7 in USA). It is estimated that the number of treatable cases in EU and USA could reach 20,000 subjects for which there are no alternative curative therapy. Considering 15,000 € per treatment cycle, the values of this potential market approximate 135 M€, and Lisapharma intends to reach 30% of this market in 5 years. The project has the potential to boost growth of Lisapharma by increasing significantly the company turnover. The total investment required is about 4.5 M€ over 3 years, for clinical studies, equipment and industrialisation, marketing and business development, with a foresee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Implementation of a CirculAr economy Based on Recycled, reused and recovered Indium, Silicon and Silver materials for photovoltaic and other applications' (CABRISS).

assistant: **Concept**

The main vision of CABRISS project is to develop a circular economy mainly for the photovoltaic, but also for electronic and glass industry. It will consist in the implementation of: (i) recycling technologies to recover In, Ag and Si for the sustainable PV technology and other applications; (ii) a solar cell processing roadmap, which will use Si waste for the high throughput, cost-effective manufacturing of hybrid Si based solar cells and will demonstrate the possibility for the re-usability and recyclability at the end of life of key PV materials. The developed Si solar cells will have the specificity to have a low environmental impact by the implementation of low carbon footprint technologies and as a consequence, the technology will present a low energy payback (about 1 year).The originality of the project relates to the cross-sectorial approach associating together different sectors like the Powder Metallurgy (fabrication of Si powder based low cost substrate), the PV industry (innovative PV Cells) and the industry of recycling (hydrometallurgy and pyrometallurgy) with a common aim : make use of recycled waste materials (Si, In and Ag). CABRISS focuses mainly on a photovoltaic production value chain, thus demonstrating the cross-sectorial industrial symbiosis with closed-loop processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A neural network builder with remotely controlled parallel computing' (NEUROCLOUD).

assistant: **Innovation**

Neural network simulations have been a driving force behind our advances in the artificial intelligence filed, but also a key tool in our understanding of the human brain. However, exploring such networks usually engages substantial computational resources requiring specific programing skills and dedicated facilities. In our main project NETSIGNAL, we have developed computational environment ARACHNE aiming to facilitate high-end neural network exploration among scientific and industrial users. ARACHNE enables an investigator to construct and explore cellular networks of arbitrary biophysical and architectural complexity using a simple interface on a local computer or a mobile device. Through small-file exchange via the internet, the interface controls a pre-configured computational kernel installed on a remote computer cluster or cloud. Uniquely, ARACHNE can integrate traditional wired network connections with diffuse, volume-transmitted type of inter-cellular signalling, to reflect the emerging role of glia in brain processing. ARACHNE thus affords a flexible neural network design and incorporates latest advances in neuroscience while providing a portable console suitable for IT-untrained explorers. ARACHNE has passed a feasibility and novelty test by independent experts (Aleksin et al, PLoS Comp Biology 2017, in press), its test version is available on-line (https://github.com/LeonidSavtchenko/Arachne/). Our goal here is to determine market potential and the commercial viability of ARACHNE and its conceptual design, but also to establish industry-standard provisions for its commercial exploitation. We plan: (a) to upgrade ARACHNE technical specs, interface, support, etc. to the industry standard; (b)  to assess the market and the competitors; (c) to determine IPR posi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New Catalytic Reactions and Exchange Pathways: Delivering Versatile and Reliable Arylation' in the context of a Seventh Framework call.

assistant: **Objectives**

This proposal details the mechanism-based discovery of ground-breaking new catalyst systems for a broad range of arylation processes that will be of immediate and long-lasting utility to the pharmaceutical, agrochemical, and materials chemistry industries. These industries have become highly dependent on coupling technologies employing homogeneous late transition metal catalysis and this reliance will grow further,  particularly if the substrate scope can be broadened, the economics, in terms of reagents and catalyst, made more favourable, the reliability at scale-up improved, and the generation of side-products, of particular importance for optical and electronic properties of materials, minimized or eliminated.This proposal addresses these issues by conducting a detailed and comprehensive mechanistic investigation of direct arylation, so that a substantial expansion of the reaction scope can be achieved. At present, the regioselectivity can be very high, however catalyst turnover rates are moderate, and the arene is required to be in a fairly narrow window of activity. Specific aspects to be addressed in terms of mechanistic study are: catalyst speciation and pathways for deactivation; pathways for homocoupling; influence of anions and dummy ligands; protodemetalloidation pathways. Areas proposed for mechanism-informed development are: expansion of metalloid tolerance; expansion of arene scope; use of traceless activators and directors, new couplings via ligand exchange, the evolution of simpler / cheaper and more selective / active catalysts; expansion to oxidative double arylations (Ar-H + Ar’-H) with control, and without resort to super-stoichiometric bias.The long-term legacy of these studies will be detailed insight for current and emerging systems, as well as re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative electronic distributyng system of manure for the farm, eliminating the environmental impact' in the context of a Fifth Framework call.

assistant: **Objectives**

The organic fluid (manure) is a natural fertiliser to the land and to the plant that support nitrogen and minerals. Actual agricultural productivity rates won't be possible without it. Nevertheless, badly dosed the manure can pollute the environment (so at atmospheric level at a frantic level) and burn the plant. Manure is even more important in ecological agriculture than in the traditional one, because it's the only fertiliser legally allowed. The control of dosage in the manure scattering machines is made mechanically and by hand, opening and closing the outlet depending on the tractor's speed, the pressure made by dung and the required dose per hectare. Nowadays, to fix the manure dose is not very exact. This control is made by the farmer who establishes the dose taking into account his experience, his soil (PH, % nitrogen, etc.), weather station and plant knowledge. The global objective of this project is to distribute the organic fluid answering to the agronomic needs, using the organic fluid as a fertiliser for the land and without any environmental impact in the atmosphere or in the level frantic. The specific objectives are the following:- To define the dung parameters that define its soil and plant feeding properties, as pH, percentage of nitrogen content or percentage of mineral content.- To develop the measuring systems of these pram...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Studies in Probability Theory and Related Fields', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The proposed project combines several studies in Probability Theory and its connections with Statistical Physics, Computer Science, Combinatorics and Approximation Theory. The first two studies aim to uncover the Gibbs-state structure of two statistical physics models in high dimensions - the anti-ferromagnetic 3-state Potts model and the hard-core model. These studies are intimately related to combinatorial questions of the rigidity of independent sets and proper 3-colorings in the high-dimensional cubic lattice. The third study aims to investigate the notion of independence sensitivity of a boolean function, a notion coming from computer science and error-correcting codes, in the context of complex statistical physics functions such as the percolation crossing function. In the fourth study we will investigate the existence and geometric properties of optimal allocations of mass in an infinite volume setting. This study continues recent developments on factor-map extensions of spatial processes. In the final study, we aim to use probabilistic and analytic tools to answer a long-standing question in approximation theory: how well can Lebesgue measure on the sphere be approximated by a prescribed number of point masses? These studies will significantly extend our understanding of probability theory and its related fields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Grid Initiative Design Study' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The EGI Design Study represents a project for the conceptual setup and operation of a new organizational model of a sustainable pan-European grid infrastructure. The project will address key questions concerning the assessment of technical and financial feasibility of such a sustainable grid service, producing a conceptual design report" addressed at member state policy makers and funding agencies. The project will interact and encourage the member states to make the strategic decisions required to establish and support a sustainable grid infrastructure, and initiate its implementation.<br/>Europe has developed a scientific grid infrastructure in and across many member states which is being used by many research communities. This has come about by investments from member states into national resources as well as by the European Commission with project awards for European flagship projects such as EGEE (Enabling Grids for E-sciencE) and support projects to develop interoperable middleware technologies and co-ordination mechanisms. At present and on a project-basis, this production service infrastructure cannot be sustained indefinitely, and there is a clear need to establish a long term technical and financial structure. This need is confirmed by a series of recommendations from the e-Infrastructure Reflection Group (e-IRG), and the European Grid Initiative (EGI) represents the coordinated effort to advance on this matter.<br/>The EGI Design Study will identify the conditions and develop the framework for a sustainable Grid infrastructure which should take over the coordination and operation of the future European grid infrastructure from today's projects. The design study will foster the emergence of a new organisational model designed to consolidate a sustainable appro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dramaturgies for languaging: Developing linguistically sustainable theatre and performance' (DRAMALANG), addressing dissemination and exploitation.

assistant: **Impact**

As European theatre, performance and film artists increasingly invite the diverse languages and language practices of a globalised, decolonial and postmigratory Europe into works across the stage and screen, pressing questions arise concerning the representation of minorities. Dramaturgies for languaging (DRAMALANG) aims to interrogate the core principles and systems driving European multilingual performance, articulate an interdisciplinary methodology for analysing the reproduction of potentially damaging knowledges for minority and low-status language speakers and make suggestions for linguistically sustainable dramaturgies to a new multilingual performance network. DRAMALANG asks the central research question: How are several languages and language practices invited into European dramaturgies to provide access to and legitimise the cultures and knowledges of minoritised and low-status language speakers? The secondary research questions are: How is a lingua franca other than Standard English negotiated in interactions?; and, how do the knowledges about minoritised languages and language practices within a European context rearticulate my findings about Indigenous and migrant languages in the global south? DRAMALANG will take shape at Aarhus University (AU), Denmark, through my observation of multilingual theatre, performance and film artists locally in Denmark and beyond, including Germany, Iceland and Romania. I will develop an interdisciplinary methodology between sociolinguistics and performance studies for analysing the reproduction of knowledge from multilingual dramaturgies and create a multilingual network of scholars and practitioners across the continent. I have pioneered a multilingual methodology like this in the global south. AU provides the necessary disc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'TOXIcology & BEE COGnition : Uncovering the Impacts of Pesticides on Honey Bee Cognition' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Honey bees play a key role in diverse ecosystems due to their pollination services. This activity depends on the capacity to learn and memorize floral olfactory and visual cues, thus bees are not only able of simple associative learning but also master higher-order forms of learning. Reversal learning (RL) and Negative Patterning Learning (NPL) help bees to effectively exploit complex environments. Foraging leads to pesticidal exposure, contributing to the concerning decline of bee health. Several studies revealed the adverse effects of pesticides on bee health, but their impact on higher-order cognition is still unaddressed. Focusing on this vital form of behavioural plasticity is important as it could reveal pesticide impairments at unsuspected low doses, as compared to simpler and more robust learning tasks (e.g. Differential Learning, DL). Thus, it is relevant and timely to explore the impact of pesticides on higher-order cognition in bees, focusing on both classic (neonicotinoid) and newer (sulfoxamine) common insecticides. Here, we aim to investigate the impact of field-realistic exposure to a neonicotinoid and a sulfoxamine on three ecologically relevant learning tasks of varying cognitive complexity (DL, RL, NPL). While DL is a case of simple associative learning, RL involves transient stimulus ambiguity and requires learning flexibility; NPL is a case of non elemental learning as stimulus ambiguity is constantly present during the learning task. These problems will be studied in the olfactory domain, using olfactory conditioning, and in the visual domain, using a virtual reality approach. These protocols will be combined with various forms of pesticide exposure. We will determine how pesticides affect higher-order problem-solving in bees and will provide insigh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Computer simulations of thermally excited molecules and materials by first principles' (TEMM1P).

assistant: **Concept**

With the rapid development of computational sciences and of high-performance computing, first principles computer simulations have become a standard for the simulation of processes in physics, chemistry, biology and materials science. Moreover, the quality of first principles methods, most of all of density-functional theory, reached recently that of experiments, which allows the prediction of new forms of condensed matter, including novel molecules and nanomaterials with specially designed building units. However, these simulations refer to the electronic ground state, while in reality and experiment the materials are exposed to elevated temperatures, where also the electronic structure should be considered to be thermally excited. We will develop, implement and validate methods to simulate processes at thermally elevated temperatures. Our target applications are the formation of fullerenes and endohedral fullerenes in arc discharge plasma, thermolysis of ammonia boranes, chemical reactions of oil sands cracking at high temperature and pressure, ion diffusion in clay-mineral nanotubes, and mass spectrometer chemistry including the formation of new molecules with untypical bonding properties and the chemical reaction of methane with late transition metal and rare earth ions, a hopeful way to produce molecular hydrogen from natural gas. All applications have in common that they occur at high temperature and partially high pressure, and hence require similar computational methods. With this proposal we would like to initiate a Transfer of Knowledge scheme where we will create synergies in developing these methods, implement them for their use in latest supercomputer facilities, and have well-trained personnel to be able to operate them in the individual workgroups.  The E