RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Evaluation and Self-Evaluation of Universities in Europe' to be submitted under Fourth Framework.

assistant: **Abstract**

The specific objective of the proposal is to improve the procedures of auto-evaluation and the knowledge of his impact on the performances of Universities in different European countries, and to develop a pluralistic and decentralized assessement of education establishments, teachers and administrative staff.The key questions to answer are: 1) under what conditions the evaluation reenforces the performance of Universities? 2) what is the most performing form of evaluation? 3) are the universities and under what conditions important actor in construction of labour market for qualified work, in particular at regional level? In order to fill its three objectives, EVALUE considers that case studies are the best methods. Five fields of evaluation will be covered: 1) external evaluation; 2) evaluation of education establishments; 3) individual and collective evaluation of teachers and of the administrative staff; 4) evaluation of the relationship between education, employment and economic development; 5) evaluation of effectiveness (diversity, history and of performance indicators). In order to understand the dynamics of the evaluation process, and for each of the five fields, EVALUE will study: the decision to evaluate, the patterns of reference, the aims of the evaluation (diversity and hierarchy), the actors and the logic of action, the organizational conditions, the devices and tools, the stages and the cost of evaluation, the results of the evaluation and their diffusion, the impacts of evaluation. The evaluation processes is compared in 8 countries in order to cover the Eropean Union from North to South. Periodic reporting. Final report presented and discussed with representatives of the European Rector Conference.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genomic Data-Fusion Platform for Omics-Driven Precision Medicine' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This PoC project aims to pave the road to commercialize a comprehensive data analytics platform enabling data-driven biomedical innovation and precision medicine. The platform is specifically designed to efficiently fuse and mine heterogeneous omic data, including genomes,epigenomes, proteomes, metabolomes, patient clinical profiles, drugs and their chemical similarities, disease and otherontologies, and other relevant omic data. The goal of this development is to provide the most advanced software platform forfusion and analytics of numerous heterogeneous multi-scale omic data that takes advantage of novel non-negative matrix trifactorization(NMTF)-based and network mining algorithms, providing dramatic improvements in the number and type offused data, quantity of data, computational efficiency and biomedical accuracy compared to the most advanced omic dataanalytics platforms currently existing.The main goal of the PoC is to close the gap between the research results of ERC Consolidator Grant, ICON-BIO, and the production of acommercial data analytics platform for the bio-pharmaceutical sector. In particular, the solution will target biopharmacompanies to embed the platform into their existing Data Science resources and enable effective andefficient application of the platform’s explainable AI methods (resulting from ICON-BIO) to optimize and guide their discoveryprocesses. The result of this effort will be the achievement of a market-ready Data Analytics Platform.


**Keywords:** Large Scale Distributed Software,   Omics  and Molecular Data Analytics,  Precision Medicine,  Data Fusion,  Large Scale Data Mining
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Group of Enterprises for a Network of Information Using Space' (EUGENIUS) targeting Horizon 2020.

assistant: **Abstract**

The Copernicus program is today at a cornerstone:•The Sentinel satellites are being deployed. Their images, associated with Third Party missions’ data are being used for delivering Copernicus core services results (at global, European, and regional levels).•The European structures (EEA, ECMWF, EMSA , etc.) and the scientific community are starting to use operationally these data and the results for a better knowledge and understanding of the key land-cover stakes and environmental monitoring.But, the regional actors who are responsible for managing (at least partially) land-cover and natural resources policies have still difficulties to get access to these data and information, and moreover are not in position to combine them with their existing geo-information systems.A group of five SMEs (TerraNIS, Spacebel, Planetek, Terraspatium and Sertit), supported by a consulting firm specialized in Space market innovation and organization (Cap High Tech), are proposing to provide the regional institutional and commercial users with operational information services. These services will take the highest benefit from Copernicus outputs, for territory monitoring and management.These SMEs have decided to put in common their complementary skills and products, in the frame of a dedicated association (called EUGENIUS). They will implement “regional hubs” (Geo-information platforms) building the first instance of the “EUGENIUS network”. These regional hubs shall deliver services in the following domains:•Urbanization monitoring and management (densification, preservation of rural and “green” areas, transportation means, etc.)•Agriculture areas and activities (crop monitoring, crop identification and classification, potential yield assessment, water resources and irrigation, etc.)•Forest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Elaboration and refinement of sensorineural dendritic architecture' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Vertebrate sensory perception and integration depend on the formation of ordered connections between sensory neurons and their target cells that occur along several steps: a- establishment of cellular identity, b- neuronal axon growth, arborization and dendritogenesis, c- somatodendritic contact and synaptic refinement. Although there is a wealth of information about the molecular mechanisms controlling neuronal cell-fate determination and synaptogenesis during embryonic development, very few studies have analyzed the long-term dynamics of sensorineural circuitry in adult animals. We are employing the zebrafish lateral-line system to understand the mechanisms that govern the formation, homeostasis and regeneration of a mechanosensory organ. We have obtained evidence that intrinsic and activity-dependent mechanisms cooperate during the elaboration and refinement of the organ’s innervation. The goal of this research proposal is twofold: to characterize the mechanisms of sensorineural dendritic elaboration and remodeling, and to analyze how sensory organs reinnervate to recover function after damage. The first aim is to perform an exhaustive analysis of the cellular and molecular events leading to the formation of neuronal topography and the kinetics of target recognition. The second aim is to characterize the contribution of sensory function to dendrite arborization, asking whether epigenetic mechanisms shape sensorineural synaptic fields in the periphery. Finally we shall analyze how the architecture of the sensory epithelium relates to dendrite arborization. Achieving these goals will help us understand how animals maintain sensory abilities throughout their entire lives. It may also provide a framework for the development of strategies of regenerative medicine aimed at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular Machines - Design the Nano-Scale Handling of Biological Antetypes the Artificial Mimics' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

We propose the set-up of a cross-disciplinary research initiative dealing with molecular machines, in particular biological and artificial motors. A close collaboration between chemists known for their expertise in designing functional (bio) molecular motors, biophysicists experienced in dealing with molecular bio machines and physicists with an excellent background in experimental techniques addressing single molecules will advance the basic understanding in this domain to be employed for the steering of molecular engines in the nanometre regime. State-of-the-art theoretical calculations will guide the experimental work and allow for its in-depth interpretation. The objective of the project is to develop new concepts and advance research tools to master the challenge of handling engines-engines at the single-molecule level. We expect that the implementation and integration of the complementary scientific approaches within the consortium will lead to synergetic research achievements. While biological systems are abundant in nature, their fuelling relies mostly on specific chemical reaction schemes and environments. On the other hand, synthetic chemists represented in the consortium have met the challenge of the design of functional artificial molecular motors. Of particular interest is the fact, that de novo designed artificial engines are frequently photo-physically and/or electrically driven, i.e., the corresponding fuelling systems can be integrated in single-molecule experimental set-ups. The long-term vision of our research initiative is, firstly, to merge the advantages of the accessible biological and artificial systems by (self-) assembling of hybrid bioinorganic working devices and, secondly, to rationalize and to operate them on the single-molecule level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Credible HYbrid eLectric Aircraft' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

CHYLA - Credible HYbrid eLectric Aircraft aims to develop a landscape of opportunities and limitations of key radical hybrid-electric technologies (battery electric, fuel cell, but also considering non-drop in fuel technologies such as Hydrogen-H2, Liquified Natural Gas) and the ""switching points"" associated to scaling such technologies between different aircraft classes. These classes are: General Aviation, commuter aircraft, regional aircraft, short-medium range and large passenger aircraft, where the focus is on up-scaling the key-technologies. This landscape of design solutions is supported through a ""credibility assessment"" of assumptions underlying the application of these radical technologies, in different technology scenarios. Additionally, the impact of radical solutions will be assessed in terms of the viability of operations, economics and safety (certification). To achieve this, the project will use an approach of integrating novel airframe technologies with a hybrid electric energy network in order to apply credibility-based multidisciplinary design optimization (MDO). In order to provide feasible starting points for this landscape and the MDO, an integrated aircraft design approach will be used with physics-based design methods for the subsystem technologies.""


**Keywords:** Aircraft Design, MDO, Hybrid-Electric Propulsion, Fuel Cell, CS23, CS25
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High quality curved aerospace composites using pultrusion manufacturing' in the context of a Seventh Framework call.

assistant: **Objectives**

The main goal of PUL-AERO is the development of a material state based controlled pultrusion process for the manufacturing of curved and partially cured stringers that comply with the stringent specifications of the aerospace industry and offer significant savings in production costs.PUL-AERO will design and build a pultrusion line for the production of linear and curved composite stringers for the aerospace industry.The main disadvantages of the pultrusion process is the difficulty in producing curved parts and the difficulty in handling aerospace grade epoxy resins, mainly due to the relevant stringent requirements regarding exposure to elevated temperatures and their slow cure (which results in slow pultrusion line speed)..PUL-AERO aims to resolve the technical problems of pultrusion when it comes to production of curved aerospace composites parts and take advantage of the benefits of the process. The main benefits of the pultrusion process are the possibility for continuous production, the repeatability of the process and the low production costs (calculated as cost per meter of composite produced).PUL-AERO will create production processes and technologies with a focus on improved cost efficiency while taking into account the environmental related aspects. The pultrusion line will be split in two stages, adding flexibility to the manufacturing of stringers with different curvatures and improving the cost effectiveness of the production. The whole process will be driven and monitored by a process monitoring and QA system that will provide real time information and control of the line.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Penumbral Rescue by Normobaric O=O Administration in Patients With Ischaemic Stroke and Target Mismatch ProFile: A Phase II Proof-of-Concept Trial' (PROOF) targeting Horizon 2020.

assistant: **Abstract**

Ischemic stroke (IS), caused by occlusion of arteries that supply blood to the brain, remains a leading cause of mortality and morbidity in the world. Disruption of blood and oxygen supply to the brain leads to neuronal death in the ischemic core within minutes. The hypoperfused tissue surrounding the ischemic core, the penumbra, is at high risk for infarction over time but still salvageable. Neuroprotective â€œbridgingâ€, sustaining the penumbra until reperfusion, may widen the therapeutic window, make recanalization treatments accessible to more patients and improve overall IS outcomes.As ischemic cell death is primarily mediated by hypoxia, increasing oxygen supply to the penumbra seems THE logical approach. In animal models of IS, normobaric hyperoxygenation (NBHO) significantly increased penumbral oxygen pressure and attenuated brain injury when initiated early after onset of ischaemia and vessel occlusion was transient (35 to 50% infarct volume reduction).The PROOF project now seeks to demonstrate that NBHO (high-flow 100% oxygen at >45 L/min via a non-rebreather mask, or FiO2=1.0 for intubation/ventilation) reduces infarct growth from baseline to 24 hours compared to standard treatment if administered â‰¤3 hours after onset of anterior circulation IS, in patients with proximal vessel occlusion and salvageable tissue at risk. The study is multi-center, adaptive phase-IIb, randomized, open-label with blinded-endpoint (PROBE design).The primary efficacy criterion will be infarct growth from baseline to 24 hours. Secondary endpoints will be NIHSS 24h, categorical shift in the pre-stroke modified Rankin Score, QoL and cognition at day 90.Potential surrogate biomarkers, health economics and societal impacts will be assessed.If NBHO proves its neuroprotective potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Identification and modulation of pathogenic Amyloid beta-peptide species' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The frequency of Alzheimer's disease (AD) will dramatically increase in the ageing western society during the next decades. Currently, about 18 million people suffer worldwide from AD. Since no cure is available, this devastating disorder represents one of the most challenging socio-economical problems of our future.  As onset and progression of AD is triggered by the amyloid cascade, I will put particular attention on amyloid ß-peptide (Aß).  The reason for this approach is, that even though 20 years ago the Aß generating processing pathway was identified (Haass et al., Nature 1992a & b), the identity of the Aß species, which initiate the deadly cascade is still unknown.  I will first tackle this challenge by investigating if a novel and so far completely overlooked proteolytic processing pathway is involved in the generation of Aß species capable to initiate spreading of pathology and neurotoxicity. I will then search for modulating proteins, which could affect generation of pathological Aß species. This includes a genome-wide screen for modifiers of gamma-secretase, one of the proteases involved in Aß generation as well as a targeted search for RNA binding proteins capable to posttranscriptionally regulate beta- and alpha-secretase.  In a disease-crossing approach, RNA binding proteins, which were recently found not only to be deposited in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis but also in many AD cases, will be investigated for their potential to modulate Aß aggregation and AD pathology.  Modifiers and novel antibodies specifically recognizing neurotoxic Aß assemblies will be validated for their potential not only to prevent amyloid plaque formation, but also spreading of pathology as well as neurotoxicity.  In vivo validations include s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Effective Clinical reasoning in Virtual Patients' in the context of a Horizon 2020 call.

assistant: **Objectives**

The European Commission estimates in the report ""Patient Safety and Quality of Care"" (2014)1 that each year 8 - 12% of hospitalized patients suffer from adverse events, including errors in diagnosis. One reason for the occurrence of such errors is a lack of clinical reasoning skills, a core competency that medical students have to learn during their studies (Norman 2005, Scott 2009).Clinical reasoning is often taught in face-to-face courses such as bedside-teaching, problem-based tutorials or during internships. Since the early nineties virtual patients (VPs) became more and more important in medical education to teach clinical reasoning skills (Cook 2009).The knowledge gap this project addresses was raised by Cook et al. (2009, 2010) and, until know, remains unaddressed. He concluded that there is no evidence how VP design variations influence clinical reasoning acquisition and that it is not fully understood how VPs teach clinical reasoning and how this process could be improved.Therefore, in this project research will be undertaken to develop and assess an effective clinical reasoning tool to be embedded into VPs, and create guidelines on how to implement the tool based on the outcomes of an interdisciplinary grounded theory approach.The success of the project builds on the applicant's strong expertise in creating, integrating, and researching VPs, as well as on her interdisciplinary background in medicine, medical education research, and computer science, which enables her to manage all aspects of the project.The project will have a major impact on the applicant's career development, enabling her to become an independent researcher and ultimately establish her own research group within the field of virtual patients.Such a detailed elaboration of clinical reasoning