RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chemical mediation of plant-herbivore interactions in Mediterranean ecosystems - modelling vegetation responses to ungulate browsing intensity' in the context of a Fourth Framework call.

assistant: **Objectives**

Plants can respond to herbivory by allocating resources to either chemical defence or regrowtb foliage. Evergreen Mediterranean woody plants are associated with nutrient-poor habitats, where biomass lost to herbivory is difficult to replace because ot nutrient deficiency, favouring plants with high levels of chemical defences. The study, focused on plant-deer interactions in Mediterranean ecosystems, will test the hypothesis that plant responses to herbivory play a key role in structuring the vegetation in these communities. The results from a combination of field and laboratory experiments, integrated with data already collected in the study area and a GIS vegetation map, will be used to produce a predictive mathematical model of the impacts of deer browsing on the plant community in different habitat types and seasons. This model, will be a valuable tool for the management of both ungulate and plant communities in Mediterranean ecosystems, which are little-studied, but of high conservation value.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Characterization of a major family of cell wall proteins of Clostridium difficile – the sortase family' in the context of a Seventh Framework call.

assistant: **Objectives**

Clostridium difficile infection (CDI) represents the most problematic hospital acquired infection in Europe. It is also increasingly recognized as a community-associated disease. Current treatments for C. difficile disease are inadequate and other strategies must be found to treat or prevent disease. C. difficile is an anaerobic Gram-positive, spore-forming enteric pathogen. After disruption of the intestinal barrier by antibiotics, spores of C. difficile germinate and bacteria multiply in the intestine. Toxins are released and cause symptoms of disease which include diarrhea, or in the worst case, pseudomembranous colitis.The crucial early step of C. difficile infection is colonization of the intestine. C. difficile, like most bacterial pathogens, displays proteins on its surface that may act as adhesins and facilitate interaction with the host in order to allow colonization.Gram-positive bacteria predominantly use their thick cell wall as a platform for display of surface proteins. Cell wall surface proteins can be covalently linked to the peptidoglycan by a sortase enzyme, a membrane-associated transpeptidase. Sortase enzymes and their substrates are promising therapeutic targets for the development of novel antibiotics. To date no sortase enzyme or substrates have been described in C. difficile, although we have identified several sortase and sortase substrate genes within the genome.The project described here will investigate the role of the C. difficile sortase enzyme and sortase substrates. A variety of state-of-the art techniques will be used to explore these proteins, including advanced molecular genetics, in vivo animal models of infection and structural biology. The characterization of sortase enzymes and sortase substrates will allow firstly a better underst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mobilisation and Accessibility Planning for People with Disabilities', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Many disabled users are prevented from accessing functionally and socially important activities such as shopping, visiting public parks, theatres etc. because of a lack of real-time accessibility knowledge. Currently the simplest of excursions can involve military scale planning to ensure that the planned journey is feasible.  MAPPED will provide users with the ability to plan excursions from any point to any other point, at any time, using public transport, their own vehicle, walking, or using a wheelchair, taking into consideration all their accessibility needs. In addition to this, MAPPED will provide the users with location-based services tailored to their accessibility needs. To meet these goals MAPPED will incorporate  1. a multi-modal route planner that allows for disability specific routing information and reservation of accessibility services 2. geographically indexed accessibility information 3. disabled friendly mobile user interfaces MAPPED will develop an intelligent system that will empower persons with disabilities to play a full role in society and to increase their autonomy". It therefore fits squarely the specific objectives of strategic objective 2.3.2.10, eInclusion. MAPPED will be clustered with ASK-IT (Ambient Intelligence System of Agents for Knowledge-based and Integrated services for Mobility Impaired Users), an Integrated Project that aims to develop an Ambient Intelligence (AmI) space for the integration of functions and services for Mobility Impaired (MI) people across various environments, enabling the provision of personalised, self-configurable, intuitive and context-related applications and services and facilitating knowledge and content organization and processing. In order to develop a system with the potential to become a European stan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'implementation of a TOXicity assessment Tool for pRActical evaluation of life-cycle Impacts of techNologies (TOX-TRAIN)' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

TOX-TRAIN is a 4-year project and its main objective is the development and implementation of a tool box to assess toxicological impacts related to the life-cycle of technologies. The USEtox model, developed under UNEP-SETAC auspices with contributions of the partners in this consortium, will be taken as a starting point. First, TOX-TRAIN will develop and implement estimation tools for emissions and chemical properties to USEtox for a number of compound groups, including ionic and amphiphilic substances, persistent bioaccumulating chemicals or metabolites, pesticides and biocides, substituted musks/fragrances, and metals, with a specific focus on assessing various types of uncertainty in emissions and properties. The compound groups are selected on the basis of use volumes, fate pattern complexity and main emission route relevance. The tools will be developed as open-source software. Second, the USEtox model will be extended with an indoor compartment model for typical exposure situations in working place and household settings as well as direct consumer exposure through a product (e.g. a directly applied cosmetic product). Third, a number of case studies will be performed in close collaboration between the commercial and non-commercial partners of TOX-TRAIN to test the USEtox tool box in practice. Finally, dissemination of the tool box will be done by a portfolio of actions, such as workshops, course developments, training of specific user groups, documentation material, and a user-friendly web-based implementation. In short, TOX-TRAIN will provide an excellent platform to enhance the transfer of knowledge between the commercial and noncommercial sector in the area of toxic life-cycle impact assessment of technologies. It is envisaged that the developed USEtox tool box
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Graphene Quantum Sensors' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Quantum sensors are the most direct application of current quantum technologies. They have shown improvement in magnetic sensors, atomic clocks, gravimeters, accelerometers, geolocalization, gas detection, imaging resolution and biomedical sensors. Nevertheless, a concrete incorporation of quantum sensors to the every day life requires to overcome fundamental challenges, such as robustness to the environmental noise and integration to the current technology.Here I show how to probe graphene for quantum sensing magnetic fields. Putting together the tools of high-harmonic spectroscopy with quantum metrology, I propose a framework capable of quantifying solid-state systems for sensing applications.Solid state materials have unique quantum features, due to their extreme sensibility to the boundary conditions. Other effects, such as superconductivity, appear in strongly correlated materials, such as twisted bilayer graphene. Analysing the high-harmonic spectroscopy in twisted bilayer graphene allows to propose experimental settings to detect  its phases of matter, electronic localisation and band structure.In this proposal I describe why graphene has the potential of working as a robust magnetic field quantum sensor. Currently, the techniques of quantum metrology and parameter estimation, allow to quantify for the first time the performance of materials in presence of of incident external fields. Here I propose to use this framework, to determine the performance of single layer and twisted bilayer graphene in presence of magnetic fields, and compare it to the available quantum sensors in the market. In this process, it is possible to pin down the key features in graphene for measuring these fields.Combining the results of fundaments of quantum metrology with high-harmonic sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'How experience shapes brain specializations' (NovelExperiSENSE).

assistant: **Concept**

The main goal of my research is to understand the origins of brain specialization and its flexibility across the lifespan. In our modern society Novel Sensory Experiences (NSE) and augmenting technologies are increasingly part of our everyday life (e.g. www.pokemongo.com). How does our brain deal with processing these new experiences? How much of its functional specializations and organization principle (e.g. topography in early sensory and motor brain areas) are already predefined by evolution and are locked after critical periods (i.e. early in life)? Our main hypothesis is that computational tasks, cognitive goals and partially innate network connectivity patterns, rather than sensory input per se, drive the emergence of brain specializations even after the critical periods pass. We base this also on our extensive experience with teaching blind to ""see"" with their ears using sensory substitution devices (SSDs) and the resulting brain specializations (including putative mechanisms).  Here, we will extend, generalize and consolidate this theory by tracking in healthy adults the development of NSE (Novel since never experienced it before during life nor evolution).  We suggest here to build 5 novel topographic devices (e.g. we developed recently the IRThermoSense for perceiving heat information and beyond walls thermal images without interfering with regular vision). We will also work with providing novel experiences to congenitally sensory deprived populations (e.g. deaf) to promote sensory restoration. In both cases, we aim to characterize the integration of NSEs in the brain using longitudinal self and supervised learning in virtual and real world environments and cutting-edge biologically inspired computational neuroimaging tools, with special emphasis on topograp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Repro- reuse process and organisation improvement experiment' (REPRO).

assistant: **Innovation**

Provida is a SME currently being evaluated as a vendor in a number of international markets, including Europe, South America and Australia. In order to stay competitive, we must offer flexible and modularised systems at short notice. The key factor for Provida in meeting this challenge is to reduce time-to-market by introduction of organised reuse. Organised reuse will increase productivity in our development process, which in turn will have a major impact on the competitive situation for Provida - especially in new markets.Hence, our objectives with REPRO are to implement development procedures and roles focusing on reuse, to build libraries of reusable components and hence, improve quality, increase productivity and reduce time-to-market.THE EXPERIMENTThe Experiment will introduce organised reuse in our development process, focusing on the following key reuse areas:1. Organisation and Project management2. Development for, respectively with reuse3. Repository management4. Metrics and measurementsTo do this, we have identified certain improvement steps; To introduce specific organisational roles, responsible for reuse, such as Domain expert, Repository Manager, Component co-ordinator, Component expert, and Reuse co-ordinator. To introduce a new tool for Repository. To improve and document our development procedures in Process Engineer. To use metrics and measurements, in order to show the cost-benefit of the above mentioned improvement steps.The project will be focused around a technical upgrade of the loan and card modules in ProRetail. ProRetail is a retail banking system running on an MVS mainframe with CICS and DB/2. The upgrade has two major objectives; to reuse the functionality of the existing older version, and to reuse the core functionality of the already upgr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Driven Glasses: from statistical physics to materials properties' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Amorphous systems form a large fraction of the solid materials that surround us, from polymer glasses to mineral or metallic glasses, from toothpaste (a colloidal paste) to granular materials. Still, a theoretical framework for describing the mechanical properties of such materials, comparable to the dislocation theory that describes crystalline systems, is still missing. Our understanding of prominent experimental feature such as the heterogeneous character of deformation, or the temperature and rate dependence of the mechanical response, is very limited.These materials indeed combine several difficulties. In contrast to liquids or crystals, they are intrinsically out of equilibrium, and their microstructure presents a large statistical distribution of mechanically distinct local environments.  The importance of the notion of heterogeneity in the mechanical behaviour of amorphous systems is being increasingly recognized, still there is no numerical or theoretical model that incorporates this microscopic feature into a macroscopic description of deformation and flow.The aim of the proposed research program is to build such models, within a multiscale approach seeking inspiration from dislocation dynamics, from the statistical physics of glasses and from the physics of dynamical critical phenomena. The proposed approach is based on a combination of intensive numerical simulations at the atomic scale and at a coarse grained scale, which will necessitate the development of efficient numerical schemes. The statistical analysis will allow us to understand the universal and non universal features of material behaviour in terms of the interactions between the atomic constituents, and to establish the validity and importance of new concepts such as mechanical activation or dyna
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Effect of microwave frequency and pulsed microwave power on meat carried bacteria' under Sixth Framework.

assistant: **Concept**

The shelf life of food products, particularly meat is very short. A process that can extend its acceptable life by a few days would reduce wastage, increase the yield of meat processing plants and improve the shelf life of super-market meat products. It is al so possible to reduce the incidence of food poisoning in restaurants and homes when the number of aerobic and anaerobic bacteria, e.g. salmonella and pathogens, is reduced by exposing them eat to microwaves. Variable Frequency Microwaves (VFM) and Pulsed Power Microwaves (PPM) can offer aviable alternative for extending the shelf life of meat products and provide better efficiency and effectiveness in minimising bacteria populations without affecting the quality of the product.This technology can also provide pasteurisation means for hermetically sealed packaged meat food. This project ultimately aims at developing methods and techniques for extending the shelf life of meats and help design facilities that can be used for high volume treatment in meat processing plants and in supermarkets as well as for low volume storage sites including restaurants and homes. The socio-economic benefits can be immense.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The sex-dependent effects of amino acid-based diets on energy metabolism: innovative approaches to manage the metabolic syndrome' (THELMA) under Horizon Europe.

assistant: **Objectives**

The stimulation of brown adipose tissue (BAT) thermogenesis and energy expenditure has gained prominence in the management of obesity and type 2 diabetes. In this context, I propose innovative nutritional strategies as efficient tools to promote BAT thermogenic program, with therapeutic effects on obesity, type 2 diabetes, and metabolic syndrome (MetS). There are four aims. Aim 1 focuses on the sex-based efficacy of essential amino acid (EAA)-based supplements and designer diets in the animal models of diet-induced obesity and in the chronic subordination stress model of MetS. I investigate whether and how sex differences influence BAT thermogenesis activation induced by nutritional challenges and the role of the sympathetic nervous system (BAT-denervated, β-less mice, optogenetic methods to evaluate the ability of diets/supplements to increase the SNS capacity). Aim 2 characterizes the role of BAT as a secretory organ, using state-of-the-art techniques (transcriptomics, metabolomics, BAT ablation/transplantation). Aim 3 studies the sex-based beneficial effects of supplements in men and women with severe obesity. Aim 4 relates to the additional non-academic placement period in Professional Dietetics, a company with a strong background in developing amino acid-based formulas for medical use, to acquire knowledge about patent management and regulatory affairs in the healthcare industry.At UMN, I will exploit the outgoing supervisor’s expertise in metabolic physiology and SNS regulating BAT function in obesity. At UMIL, I will refine the knowledge and skills acquired during the outgoing phase. My final goal is to implement individualised and sex-based guidance to ameliorate metabolic disorders. This result will place me privileged to establish myself as a competent researc