RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'The European Virtual Observatory - VO Technology Centre'.

assistant: **Innovation**

A Design Study will be undertaken aimed at completing all technical preparatory work necessary for the construction of the European Virtual Observatory (Euro-VO). Euro-VO is a specifically European implementation of the Virtual Observatory (VObs) concep t, and will produce a world leading infrastructure providing a unified virtual data resource and the ability to peform complex data discovery and manipulation tasks across the whole range of astronomy. Access to data and tools will be equally good across Europe, regardless of location. This will require establishing an alliance of data centres, and a VObs facility centre in support of the community, but crucially requires the construction of an infrastructural glue of software components, in the context of rapidly evolving background developments in IT and the grid. The VO-TECH project aims specifically at feasibility studies and design work aimed at integrating such new technologies into the Euro-VO. Key IT advances to build on are in intelligent reso urce discovery (ontology and the semantic web), data mining, and visualisation capabilities. These will be integrated via global astronomical interoperability standards coupled with the latest distributed grid computing services. Additionally this projec t covers design and preparatory work to ensure that data from the major European telescopes and facilities (as represented by the Opticon and RadioNet networks) is fully accessible through the Euro-VO.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Geoparks: Heritage, Education and Sustainable Development - an Innovative Methodology for Southern Countries. Case Study in Morocco (Atlas Mountains, Marrakech)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

According to the Charter of the European Geoparks Network adopted in Greece the 5th June of 2000, a European Geopark “is a territory which includes a particular geological heritage and a sustainable territorial development strategy supported by a European programme to promote development. […]”.These territories have been labelled regarding their geological, cultural and ecological heritage - since the early 2000s this Label knows a growing success among European countries, particularly in the West (France, Germany, Italy, Spain). In 2013, 54 European Geoparks received the precious label. This international recognition by UNESCO attracts Southern countries to implement development strategies in line with the recommendations of good-practices management oriented by international organizations. Indeed, UNESCO takes into account a plurality of selective criteria such as a remarkable heritage (geology, archaeology, biodiversity, cultural), citizen participation, sustainable regional economic development plan, heritage and socio-economic values for local populations, etc. to proceed to the inscription process. It is based on an integrated and sustainable management & conservation strategy of natural and cultural heritage from an interdisciplinary approach (Humanities and Life & Earth Sciences) in consultation with local stakeholders (local communities, universities and civil society). Currently, there is no “Geopark methodology” adapted to the South. Thus, the GEOPARK project aims to study potential and compared areas (EU/Africa) with remarkable geological, ecological, social and cultural heritage. One located in Central Catalunia (Spain) and the other in the Zat Valley (Morocco) - Marrakech. Endowed with varied skills in Humanities and Life and Earth Sciences, GEOPARK projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inventing the Aesthetic: A Historic-Theoretical Approach' (2007-2013) under Seventh Framework.

assistant: **Objectives**

By “the aesthetic” I mean a radically modern phenomenon emerging in the second half of the 17th and early 18th centuries, and not an adjective referring to the common set of philosophies (metaphysics) of beauty and / or theories of (fine) arts in general. I rather consider it as a new perspective, sensibility or attitude without precedent in Antiquity or even the Renaissance, which plays a constitutive part in the formation of modern European culture (manners, communication, education, institutions, etc), and which, by virtue of its ever close connections to social and moral issues, also has a great and profound political relevance. This new perspective makes a special experience possible in which transcendence can be grasped through the indispensable sensual; and this new form of experience can and does reconfigure and shape both the “nature” of transcendence, and the self of the beholder. I am pursuing my research into its genealogy in the period between the 1630s and the 1730s. My aim is not to create a new European history of aesthetics; I am attempting to distinguish the relevant discourses (including the discovery of new texts and authors still not integrated into this subject), to reconstructintellectual models and spiritual attitudes on the basis of and through the interpretation of mainly theoretical texts written during that 100-year span. The main threads of new aesthetic discourse are of quite different natures — incorporating theology, rhetoric, natural science, moral and social philosophy, philosophical anthropology, epistemology, conversational literature in general, and, to an extent, theories of visual arts and literary criticism, too —, even as they influenced and mutually fertilized each other. The intellectual historical reconstruction of the process
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unraveling the protein glycosylation of Plasmodium falciparum is crucial for development of novel therapeutics against malaria' (SugarBlock).

assistant: **Concept**

Annually, malaria causes 200 million clinical cases and more than half a million deaths. Works carried out more than 40 years ago demonstrated that a malaria vaccine offering sterile protective immunity in humans was possible, but the efforts to develop a modern, recombinant ‘subunit’ malaria vaccine only confer short term protection against clinical malaria in 35-50% of recipients. Several evidences support the presence of foreign short N-glycans and other minor glycosylations in the surfaces of the parasite, Plasmodium faciparum, the causative agent of malaria. In addition, recent studies show that Plasmodium sporozoites present also unknown α-galactose containing antigens in their surface and that antibodies against them provide sterile protection against malaria in mice. We propose to completely characterize the protein glycosylation present in the surface of the extracellular sporozoites, that travel from the mosquito to the liver, and merozoites, that invade human erythrocytes. We will use different quasi-targeted glycoproteomic approaches, based on the expected simplicity and low variability of these glycosylations in the parasite surface and their affinity to well characterized lectins. The investigation of these uncommon parasitic glycosylations may expose an unexpected Achilles’ heel in the Plasmodium parasite that could be exploited to halt sporozoite development and/or stop merozoite invasion and induce protection against malaria, mimicking what has already been achieved using carbohydrate-protein conjugate vaccines against bacterial infections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ENDOSCAPE, a clinically applicable non-viral gene delivery technology' (ENDOSCAPE).

assistant: **Innovation**

Gene therapy is one of the most promising treatment options for future advanced therapies in a broad range of diseases. Successful gene delivery requires the recognition of target cells as well as cytosolic and nucleosolic uptake of the gene. Currently, non-viral based gene delivery such as transfection reagents are only suitable for in vitro applications, and clinical gene therapeutics delivery is accomplished via viral vectors, which still has major safety concerns as well as complex and costly manufacturing procedures, preventing future implementation for the treatment of diseases with large patients groups. In the last 15 years, a class of secondary plant metabolites has been discovered that selectively mediates endosomal escape and cytoplasmic delivery of macromolecules specifically at low endosomal pH, thereby inducing a 40-fold enhanced gene delivery efficacy in vivo. However, endosomal escape enhancers and gene therapeutic product must be applied as two components, thus complicating therapeutic approval and clinical applicability. The ENDOSCAPE technology platform will develop and collect proof of concept for a non-viral gene delivery technology where endosomal escape enhancers, gene therapeutic product and targeting ligand are all bound to one molecular scaffold. Proof of concept of the ENDOSCAPE technology has a major impact on the therapeutic opportunities for current and future macromolecule drugs for a broad range of diseases and large patient groups. All this induces new biotech-based businesses, new research projects and creates new technology platforms for development of new macromolecule therapeutics for a broad range of disease indications. The non-viral based ENDOSCAPE technology will enhance therapeutic efficacy with lower therapeutic dose thereby re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Combinatorial Structures and Processes'.

assistant: **Concept**

The project brings together combinatorialists of various fields with the aim that they will enrich each other’s techniques. The tool kits they will bring include topology, probability, statistical physics and algebra. These should apply to matching problems (a central topic in combinatorics), algorithmic problems, coloring problems (which are decompositions into independent sets or matchings) and homomorphisms (a generalization of colorings).One umbrella under which many of these can be gathered is the intersection of two matroids, a notion generalizing that of matchings in bipartite graphs. Researchers are baffled by a strange phenomenon – that moving from one matroid to the intersection of two matroids sometimes costs little. The algorithmic problems are indeed harder, but the difference between min and max in the min-max theorems suffer only a conjectured penalty of 1.This connects with a second direction of the research, fine grained complexity, which deals with polynomially solvable problems, and aims to prove, under widely believed assumptions, lower bounds on the exponents in the polynomial bounds. A major question in the field is proving similar tight bounds for approximation problems.A direction connecting matchings, colorings and homomorphisms was initiated recently in statistical physics. It investigates typical algorithmic complexity, of computational problems taken under some probability distribution. While the worst case complexity questions are difficult in general and not clearly practically relevant, when we restrict to a given probability distribution of instances and when we are interested in high probability results, progress has been made, that has contributed also algorithmic insights beyond the probabilistic setting. We propose to address several
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A study of round-fish and nephrops survival after escape from commercial fishing gears' in the context of a Fourth Framework call.

assistant: **Objectives**

A. To investigate survival of roundfish and Nephrops after escaping from commercial fishing cod-ends, and Nephrops survival after being discarded from the vessel's deck.B. To quantify the effects of demersal trawling duration and towing speed on the survival of commercially important roundfish after their escape from the cod-end.C. To assess the implications of this information for fisheries management of fish and Nephrops stocks.A sheltered site will be chosen in each of the three years of the project, and cages set up for housing fish and Nephrops for survival monitoring. Cages for Nephrops will be equipped with artificial burrows to prevent cannibalism and fighting. Each experimental category will be triplicated in order to assess variability of the results. Triplicated controls will also be set up. Control fish will be caught with rod and line on barbless hooks. Control Nephrops will be caught by creel.A commercial fishing vessel will be chartered in each of the three years to catch Nephrops and/or fish for the experiments. The vessel will be typical of those operating in mixed fish and Nephrops fisheries. New trawls and cod-ends of the appropriate size and types will be purchased.Selectivity of the fishing gears used will be assessed using either the covered cod-end or twin trawl technique, depending on the capability of the vessel chartered.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hybrid Virtualized Testing for Certification of EGNSS in Railway Train Positioning' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

VICE4RAIL aims to accelerate the adoption of EGNSS for deploying efficient, resilient, and competitive ERTMS solutions. Focus is on the development of a certification and standardization process for the use of EGNSS, closing the gaps for rail safety critical applications and converging towards a pan-European EGNSS-based solution for ERTMS and its global roll-out. The starting point is the use of EGNOS V2 and the Balise virtualisation – as indicated by the European Parliament directive on July 2021 – opening the way for further applications based on the absolute train positioning and EGNOS V3. Two major developments will be undertaken: identification of suitable certification procedures compliant with the CENELEC norms and realization of a Hybrid Virtualized Testing Certification Environment based on the zero-on-site testing paradigm with the construction of a dedicated testing facility on a RFI’s railway lines where GNSS-based multisensor positioning solutions can be evaluated and certified in operational scenarios. This unique testing environment will be connected with the ERTMS accredited laboratory of CEDEX to assess the end-to-end performance of the ERTMS chain with GNSS-based positioning devices in operational scenarios. Behaviour of the system under GNSS signals that include faults very rare and difficult to experience  field but with a potential high impact on safety, can be evaluated avoiding extensive and not exhaustive field tests. VICE4RAIL will exploit the synergies with the Pilot Line Novara – Rho funded by RFI to integrate GNSS positioning into the ERTMS and the Shift2Rail GATE4Rail project that introduced the zero-on-field virtual testing for GNSS. Furthermore, thanks to SNCF, CEDEX, RFI and SOGEI a liaison will be established with the Europe’s Rail R2DAT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Integrated nanoparticle isolation and detection system for complete on-chip analysis of exosomes'.

assistant: **Concept**

The aim of Project INDEX is to isolate and characterize nanoparticles available in bodily fluids through development and integration of novel technological breakthroughs. The technology will enable the analysis of clinically valuable nanoparticles called exosomes towards new generation diagnostics. Exosomes are known to mediate communication between cells and their effective utilization holds a great promise of revolutionizing the standard of clinical care. However, their detection and molecular profiling is technically challenging. The proposed technology will isolate exosomes that are as small as 30nm in diameter from human plasma with high purity, and provide in-depth, multi-parameter characterization of the particles through digital counting, size determination, and biological phenotyping. Towards this goal: (1) Novel microfluidics will be developed and used for efficient magnetic enrichment; (2) Isolated particles will be detected and analyzed with a novel biological nanoparticle (BNP) sensor (3) Immune-capture and release chemistries as well as phenotyping assays will be developed; (4) Critically, complete on-chip integration of isolation, detection and analysis will be accomplished; (5) Utility of in-depth exosome characterization will be demonstrated with clinical samples for lung cancer. Project INDEX requires successful integration of multiple sub-units and assays that each represents technological frontiers, which is extremely challenging. However, the breadth of information on exosomes that will be available with the integrated system is unmatched. Although, the clinical utility of exosomes is still developing, the uncertainty can only be clarified through automated technologies that provide latitude of information. Once completed, Project INDEX can demonstr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Big data meeting Cloud and IoT for empowering the citizen clout in smart cities', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

As we enter 2016, the world is facing a number of critical challenges such as global warming, economic crisis, security threats, inequality, natural disasters and ageing society. Urban areas are particularly affected, given that the world population is increasingly concentrated in those areas. ICT solutions have the potential to change the world and improve the quality of life and security of its citizens. In particular, IoT, cloud and big data are today’s key enablers for increasing the efficiency in using shared urban infrastructure, economic and natural resources.The overall concept of the BigClouT project is to give an analytic mind to the city by creating distributed intelligence that can be implanted in the whole city network. The unprecedented number of connected things and the associated big data naturally raise new technical challenges in terms of interoperability, scalable and online data processing, actionable knowledge extraction, self-management, security and privacy. The BigClouT project is bringing together resources and knowledge necessary from prestigious European and Japanese institutions for tackling those challenges. BigClouT will leverage the results of the ClouT project and bring them several steps further and add, in particular, distributed intelligence with edge computing principles, big data analytics capability and self-awareness property. The BigClouT platform will be deployed and validated in 4 pilot cities in the project, Grenoble, Bristol, Tsukuba and Fujisawa. BigClouT gives a particular importance to the involvement of citizens during the whole lifetime of the project, from use case definitions to validation. BigClouT has also the ambitious objective of creating a community of external end-users to build their own applications/business on