RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Combatting Antimicrobial Resistance Training Network' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

CARTNET trains young researchers in Europe to address serious and global problems of antibiotic resistance. Disease-causing bacteria are becoming resistant even to last resort antibiotics and transmission of resistance genes and resistant pathogens is widespread between human, animal and environmental reservoirs. Therefore, CARTNET will focus on alternative approaches to handle antibiotic resistance and treating resistant infections in both humans and animals. It will provide competences to young researchers and future policymakers that will allow them to use knowledge at all relevant scientific levels and in collaboration with stakeholders in both human and veterinary medicine as well as in chemistry, structural biology and natural product chemistry to develop new antimicrobial solutions. CARTNET comprises researchers who are leading experts on antibiotic resistance and antimicrobial drug discovery. They will in cooperation with the recruited early stage research (ESR) trainees use structural biology to synthesize new antimicrobials, screen environmental microorganisms and microbiota for new active compounds and limit spread of resistance through knowledge of dissemination of mobile genetic elements. The research training is hosted by universities with a strong track record of graduate training and is composed of an ambitious scientific program flanked by essential generic training courses and with ample opportunity for networking at network meetings, conferences and shared secondments. In addition to training young researchers for the challenges of tomorrow CARTNET will from day one provide excellent research with impressive scientific and societal impact.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Concerted action on risk assessment for contaminated land' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The primary objective of the concerted action on risk assessment for contaminated sites are: - to identify, compile, assess and review all relevant RTD projects and scientific approaches for risk assessment developed in the Member States of the European Union. - to propose scientific priorities for future programmes and projects of the European Commission and the EU Member States. - to elaborate guidelines and recommendations for assessing risk of contaminated sites.The concerted action will concentrate on the coordination of research activities on risk assessment for  contaminated land within Europe and will develop recommendations and guidelines based on the current state  of knowledge. The general technical approach to achieve these goals will be as follows:  -identification and synopsis of respective RTD (Research and Technical Development) projects in the Member Sates.  -identification and compilation of relevant RTD projects funded by the European Commission under the Environment and Climate" programme and other specific programmes. -exchange of information and results with the Scientific Committee of the present EU study "Comparative study on the different national approaches of risk assessment and remedial investigation at a contaminated site".  -assessment, review and discussion of the objectives and the results achieved of the above-mentioned RTD projects. Evaluation of the different guidelines for comparative risk assessment, for detailed risk assessment, for setting priorities and technical instruments and scientific tools.  -compilation of all project information and drawing up of a status report about RTD projects on risk assessment. Creation of technical and scientific assumptions for a future harmonisation of risk assessment in the European Union.  -iden
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Strengthening epidemiological, genomic and community surveillance of Mpox virus (MPXV) at the Congo River border for DRC and RoC' (MPXV), addressing dissemination and exploitation.

assistant: **Impact**

The spread of Mpox virus (MPXV) in Sub-Saharan Africa, specifically Democratic Republic of Congo (DRC) and Republic of Congo (RoC) presents an urgent public health concern with global implications. MPXV cases have been reported across 114 countries with 89,752 confirmed reports and >150 deaths. It has the highest prevalence in DRC and has resulted in twice the number of deaths in the African region compared to Europe. RoC, a DRC bordering country, is also experiencing a surge in positive cases, highlighting an urgent need for data-driven efforts to identify transmission routes and implement public health initiatives. MPOX-PROBE is responding to this call for action with an international consortium and activities in three main pillars (1) improving epidemiological surveillance of Mpox with new diagnostics and sampling efforts including high-risk areas and vulnerable populations; (2) capacity building to improve diagnostic and research capacities of researchers and public health workers in DRC and RoC; (3) strengthening public health response by sharing surveillance data and newly developed spatiotemporal risk and transmission models for Mpox. Through MPOX-PROBE, this consortium will create actionable data to uncover MPXV transmission routes and natural reservoirs facilitating development of effective interventional packages. The transmission and risks models will allow prediction of future or emerging outbreaks and develop initiatives to prevent further spread. Together, these efforts will benefit vulnerable populations and general public in sub-Saharan Africa alike while also performing ground-breaking research to understand transmission mechanisms.


**Keywords:** Mpox virus, MPXV, Congo, outbreak response, epidemiological surveillance, novel diagnostics, laboratory ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Task-relevant cognitive maps and their role in spatial decision-making' under Horizon Europe.

assistant: **Concept**

One of the hallmarks of our cognition is the ability to decide by thinking several steps ahead using an internal cognitive map. In the wild, map-based decisions can enable animals to select a target location based on the amount of food available and the cost of reaching there. But how are such decisions made? For example, how does the brain evaluate a nearby location with a small amount of food versus a distal location with more food? What if the route to the distal location is steep? Such spatial decisions are unique because evaluating a location depends not only on the learned properties of the location but also on inferred properties, like distance, that are estimated from an internal map. However, where or how in the brain are these maps stored and how they enable spatial decision-making remains unknown. Here we will address this question through three specific aims. First, we will test how animals choose among reward sites located at various distances, each dispensing different reward amounts. Next, we will investigate how animals deduce the costs and benefits associated with different trajectories in an environment to make an informed decision. Finally, we will decipher how these internal cognitive maps are formed. These questions will be studied using novel behavior paradigms with rats as the animal model. As rats perform these tasks, simultaneous activity of hundreds of neurons will be recorded from multiple brain regions using novel custom-built devices. To study the internal map formation and the mechanism of map-based decision-making, the neural activity will be analyzed using state-of-the-art machine learning techniques. Finally, the causal role of the corresponding brain regions in spatial decision-making will be tested using optogenetic perturbation experi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Geographic mosaic of ant-plant intercations in helleborus foetidus: effects of morphological and chemical seed traits on dispersal by ants' under Fifth Framework.

assistant: **Concept**

We propose to explore the patterns of geographic variation of the interaction between Helleborus foetidus elaiosome-bearing seeds and its ant dispersers. Our study focus on the matching between structural and functional characteristics of the ant communities and seed traits (morphological and chemical characteristics of the elaisomes) at a large scale. We consider a multivariate approach, integrating chemical, behavioral and ecological techniques, to elucidate patterns of within and between-population interaction outcomes within the evolutionary framework of the Thompson's geographic mosaic theory of coevolution. The two major objectives of the project are:1 ) to analyze between-population variation in the magnitude and pattern of seed dispersal by ants;2) to assess how the differences in ant community composition as well as seed traits may explain within- and between-population differences in the myrmecochory. Three specific questions are addressed:1 ) Is there any significant geographical variation in the size, shape and chemical composition of H. foetidus elaiosomes?2) Do abundance and species composition of local ant communities vary among H.foetidus populations? If they do, and on the basis of experimental evidence on the response of different ant species to H.foetidus diasporas, is this variation in ant communities related to differential dispersal for H foetidus diasporas?3) Could geographical variation in diasporas traits be interpreted as reflecting the variation in the dispersal-related characteristics of the local ant communities?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Exposure to low levels of benzene, interindividual biological variability and cancer risk'.

assistant: **Innovation**

Objectives:The project aims at further clarify the mechanism(s) of benzene toxicity and the role of low level occupational benzene exposures by integrating individual exposure data, biological markers of dose, and susceptibility with early and delayed health outcomes in the same study populations.Brief description:Information about causal mechanisms will be gathered through the conduction of a cross-sectional biomarkers study on exposure-stratified samples of active workers. Cohorts of European workers exposed to low levels of benzene (range 0.01-10 ppm) have been identified (No.=80,000), including petrochemical workers from Bulgaria, Italy and Great Britain, filling station attendants and traffic wardens from Genoa and Milan in Italy, and bus drivers from Genoa.A cross-sectional study will be conducted on samples of actively employed workers from each of the selected cohorts, with controls chosen from suitable non-exposed populations. Biomarkers will be employed to precisely characterise individual exposure levels. The markers to be used include trans,trans-muconic acid in urine as a marker of internal dose; benzene oxide-hemoglobin-S-phenylcysteine adduct as a marker of biologically effective dose; and differential white blood cell count, and single strand breaks in leukocyte DNA as markers of early biological effect. The study will determine the genotype of each individual, with respect to polymorphisms of the CYP2E1 and NQO1 genes, to address the hypothesis that individual differences in sensitivity to the biological effects of benzene exposure may be related to genetic differences in the function of these benzene metabolising genes.Information about the cancer risk associated with low levels of exposure to benzene will be generated by the conduct of an historical m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Training in Extracellular Vesicles: for benefit in Health and Disease' (TRAIN-EV), addressing dissemination and exploitation.

assistant: **Impact**

Exosomes and microvesicles/ectosomes, collectively termed extracellular vesicles (EV), have attracted much recent interest because of their potential functions, use as disease biomarkers and possible therapeutic exploitation. Due to their enormous relevance, this relatively new field of research is quickly expanding. While Europe leads the field of EV research, there are still many gaps in knowledge that need to be addressed to ensure optimal exploitation of EVs from health and Europe’s economic benefit. Addressing this, TRAIN-EV’s objective is to provide excellent and integrated multi-disciplinary and inter-sectoral training of a critical mass of ESRs of outstanding potential in the academic, clinical, and industry/business components of exploiting EV, while performing novel cutting-edge research to address these gaps and generate new knowledge. This will be achieved by appointing 15 ESRs into 10 Beneficiary Organisations (6 academic; 4 non-academic), with 4 additional Partner Organisations (3 non-academic; 1 academic) offering secondments, training and additional networking opportunities. All Participants have highly relevant and complementary medical/science/engineering/business expertise –detailed within– that will collectively contribute to the training, to PhD level, of these 15 ESRs as academic and industry EV leaders for the future.


**Keywords:** extracellular vesicles,  exosomes,  cell-to-cell communication,  cancer,  inflammation,  autoimmunity,  biomarkers,  therapeutic targets,  drug delivery,  training,  industry,  clinical,  academia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolution of Continental Strength from Rifting to Collision - A Journey through the Wilson Cycle', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Our knowledge of the geological evolution of continents, as well as of earthquake cycles and distribution, depends on a thorough understanding of continental strength and rheology. However, there is no scientific consensus about variation of strength with depth, and it seems unlikely that a single rheological model can be applied to the continental lithosphere. A key aspect is the strength of the continental lower crust, which is thought to depend on the water content of rocks and its effect on their creep strength.The distribution of deformation and strength in the continental lithosphere is likely to depend critically on the tectonic environment. This proposal aims to model the strength evolution of the lower crust from rifting to continental collision, and to do so with an innovative multi-disciplinary and multi-scale approach. The project will: test whether the strength evolution of the lower crust is determined by cycles of dehydration and hydration; determine the quantities of water required to weaken the lower crust and promote viscous flow; assess the duration of dehydration/hydration events in the lower crust, and the provenance of infiltrated fluids by means of isotopic studies.The focus of the project will be high-strain zones in granulite bodies that record rifting and subsequent continental collision. A combination of structural geology, petrology, infrared spectroscopy and isotope geochemistry will shed light on the rheology of such lower crustal rocks. The research dataset will be used to apply geodynamic models assessing the relation between collision styles and varying crustal creep strength, as well as the validation of experimental flow laws to geological temporal and spatial scales. The project will thus bridge the gap between detailed grain-scale in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'RNA biology and neuroglial function: resolving the cellular and subcellular transcriptome in myotonic dystrophy brains, towards new brain gene therapy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

RNA biology is critical for the molecular orchestration of the interplay between specialized brain cell types, and disrupted RNA processing, can cause human disease. A prime example is Myotonic Dystrophy type 1(DM1), a multisystemic disorder caused by the expansion of a non-coding trinucleotide DNA repeat and that involves cognitive impairment and behavioral changes. Molecular pathogenesis is driven by the nuclear accumulation of RNA foci, which sequester RNA-binding proteins that regulate splicing, polyadenylation and subcellular localization of downstream transcripts. However, we do not know the cell populations, molecular pathways and cell-cell interactions primarily affected in the brain. A critical question to develop effective molecular therapies.  My host laboratory developed a unique mouse model of DM1 that mirrors the spatiotemporal expression of toxic RNA and relevant brain phenotypes. Using these mice, I will fill three knowledge gaps:(1) I will employ advanced spatial transcriptomics to unravel the vulnerability of diverse cell types throughout brain development and aging;(2) I will use the TRAP technology to uncover subcellular transcriptomic abnormalities in specialized neuron-astrocyte contacts and identify pivotal disease intermediates of neuroglial miscommunication;(3) I will use my expertise in AAV-mediated brain gene delivery to test the capacity of engineered protein decoys, developed in my host laboratory, to release the RNA-binding proteins sequestered in brain cells and correct the behavioral, molecular neurobiological deficit in DM1 mice. Through the integration of cutting-edge transcriptomics with a new focus on synaptic neuroglial communication, I will elucidate DM1 brain pathogenesis with unprecedented spatiotemporal resolution, and offer a fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Enzymatic controls on sulfur isotope fractionation: implications for isotope biosignatures' (ECOSIF) under Sixth Framework.

assistant: **Objectives**

The sequential reduction of sulfate to sulfide during dissimilatory sulfate reduction leads to a mass-dependant fractionation of sulfur isotopes. As a result, sulfide becomes enriched in lighter isotopes relative to sulfate. This difference in the isotopic composition has been used as an indicator of biological sulfate reduction in sedimentary sulfides and oceanic sulfate preserved in the geologic record. Indeed, sulfur isotope evidence suggests that sulfate-reduction dates back to the Archaean, making it one of the earliest metabolisms on Earth. Interpretation and identification of biological sulfur fractionation in the geologic record depends on how well we understand the physiological and environmental factors controlling fractionation. It is well documented that biological reaction networks of sulfate reduction, control isotopic fractionations of multiple sulfur isotopes. The extent of fractionation depends on physiological differences between organisms, as well as environmental variables that influence sulfate-reduction rates. Two key conserved enzymes involved in the reduction of sulfate to sulfite (APS reductase), and sulfite to sulfide (dissimilatory sulfite reductase), impart significant fractionations during sulfate reduction. Precise fractionation f actors associated with these enzyme-catalyzed reductions however, have never been well characterized for any organism. We propose to examine how purified enzymes of selected sulfate-reducers fractionate multiple sulfur isotopes. Temperature-dependant activity assays will be used to determine fractionation patterns over the full range of activity of each enzyme. Isotopic abundances for sulfate, sulfite and sulfide will be determined for multiple sulfur isotopes. The results from these experiments will place crucial