RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multimodal X-ray and Hyperspectral Thin-Film Nano-material Evaluation and Quality Imaging' to be submitted under Horizon 2020.

assistant: **Abstract**

Functional performances of nano-materials and thin films with nano-scale thickness are determined not only by material selection but also by their nano-physical dimensions, nano-scale structure and their nano-scale chemical composition. Precise characterisation of these properties is critical to develop new functional nano-materials and optimise processes toward higher performance, improved reproducibility and yield and up-scaling to larger quantities. X-ray characterisation techniques such as X-ray diffraction analysis (XRD) or X-ray reflectometry (XRR) are widely used in research laboratories for this task but are rarely used in industrial material development and assessment of production processes due to technical limitations and required high level expertise. The project NanoQI targets the development of an industry-suited, real-time and in-line capable technique to characterise nano-structure and nano-dimensions of (thin-film) nano-materials by optimisation of area-detector based XRR and XRD concepts and their multi-modal combination with a novel wide-angle hyper-spectral imaging (HSI) technique. Therewith, NanoQI will provide industry access to real time evaluation of nano-material geometry, structure and morphology and correlative imaging of deviations of these properties. NanoQI technology will be demonstrated in three relevant industrial application scenarios: in-situ process assessment in manufacturing of perovskite solar cells; large-area vacuum roll-to-roll coating of polymer webs and industrial atomic layer deposition of dielectric and gas barrier layers.


**Keywords:** X-ray diffraction analysis, x-ray reflectometry, hyperspectral imaging, thin-film nano materials, crystallinity, crystal orientation, surface roughness, surface defect imaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NKT cells, CD1 expression and lipid presentation in intestinal immunity' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The mammalian intestine is colonized by trillions of microorganisms that are critical for the establishment of tissue homeostasis. Consequently, the immune system has developed strategies to maintain a mutualistic relation with the microbiota while stopping microbial spread. However, inappropriate function of the immune cells and/or alteration of the commensal composition can lead to inflammatory and autoimmune diseases, like inflammatory bowel disease.Among the components of the intestinal immune system, NKT cells represent a predominant population with striking immune-modulatory properties. NKT cells specifically recognize and are activated by lipid antigens presented by the MHC-I-like molecule CD1. Upon antigen encounter NKT cells can induce the downstream activation of both innate (NK cells) and adaptive (B cells) immune cells. In line with the abundance and diversity of microbial-derived lipids present in the gut, numerous studies have proposed a role for NKT cells and CD1-lipid presentation in the modulation of mucosal immunity both in homeostasis and disease. However, the features of intestinal NKT cells and the mechanisms by which they exert their immunomodulatory functions remain poorly explored.This proposal aims to unravel the cellular and molecular mechanisms that mediate the role of NKT cells in the regulation of mucosal immunity. We will use a combination of flow-cytometry, immunofluorescence and microscopy to build a comprehensive picture of NKT cell distribution and phenotype within gastro-intestinal compartments. With this established we will analyse the role of NKT cells in intestinal homeostasis by deciphering their contribution to the generation and quality of intestinal B cell responses. These studies will provide a better understanding of the facto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EuroConference on Risk Management in Power System Planning and Operation in a Market Environment' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The emergence in Europe of a market structure in the Electric Power Sector raises new management, planning and operation problems to be faced by utilities. The competition factor adds a new axis of uncertainty to the space of decisions. In fact, many experts believe that processes developed to support decision-making such as stochastic optimisation should be replaced by risk analysis paradigms. The RIMAPS project aims at stimulating the emergence of more researchers in this multidisciplinary area of Power Systems, Economics and Decision Making and at closing the gap towards the evolution in the United States, taking into account the specific cases in the diversity of European regions. Also, this initiative will offer a space for the improvement and understanding of structural changes taking place in Europe improving and strengthening the Europe's competitive edge. Therefore, two Conferences are now foreseen, the first aiming at launching the discussion and the second aiming at assessing the progress in an, in fact, rather moving legal and business environment.Young scientists will be invited to produce original contributions and supported on participation on both meetings. Tutorials and keynote speeches will be delivered by invited international top experts: RIMAPS'2000: Ron N. Allan, UK (IEEE Fellow); Roy Billinton, Canada, (IEEE Fellow); Kevin Tomsovic, USA; James D. McCalley, USA; Tomas Gomez, Spain; Armando Leite da Silva, Brazil, (IEEE Fellow); Vladimiro Miranda, Portugal. RIMAPS'2001: Erkki Lakervi, Finland; Hugh Rudnick, Chile, (IEEE Fellow); N. Hatziargyriou, Greece; N. Jenkins, UK; James D. McCalley, USA; Tomás Gomez, Spain; Vladimiro Miranda, Portugal.RIMAPS events will be organized by the Power Group of INESC Porto. RIMAPS'2000 will take place the TecnoPólo d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Academic-Industrial Training Network on Alpha-Synuclein-related Brain Diseases', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is characterized pathologically by the accumulation of aggregated conformations of the presynaptic protein alpha-synuclein (ASYN) in cytoplasmic inclusions termed Lewy Bodies (LBs). Furthermore, aberrant aggregated species of ASYN accumulate in various disease states, such as Multiple System Atrophy, Diffuse LB Disease, LB Variant of Alzheimer’s Disease and others, collectively termed synucleinopathies. Point mutations and multiplications of the ASYN gene have been identified in PD, and there is also genetic evidence linking ASYN to sporadic PD. These data suggest that aberrant conformations of ASYN plays a central role in the pathogenesis of genetic and sporadic PD and likely of other devastating neurodegenerative conditions. The aim of this proposal is to create a network of European partners who will examine, using state of the art in vitro assays, and diverse cellular and animal models, including novel cellular and in vivo imaging modalities, ASYN conformations, regulation, and mechanisms of toxicity. Through this work, biomarkers and experimental therapeutics targeting ASYN will be tested. This network will create the opportunity for training of a number of early stage researchers in the diverse fields of protein chemistry, biochemistry, cell biology, neurobiology, and animal modeling of nervous system diseases, within an interdisciplinary setting, while exposing them to both Academic and Industrial environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Profiling of tumour cells in blood for personalized treatment of metastatic cancer' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

ChallengeUp to 40% of patients diagnosed with metastasised breast cancer fail to respond to treatment. Cancer cost the EU €126bn in 2009 incl. productivity losses of €42.6bn and lost working days worth €9.43bn. 3.2m citizens in EU lose their lives to cancer each year.SolutionCirculating Tumour Cells (CTC) are cells that have shed into the vasculature from a primary tumour and circulate in the bloodstream. CytoTrack has developed a breakthrough technology that can identify and isolate metastatic cancer cells from a blood sample. It is superior to all other technologies due to a very efficient and non-biased detection principle and an integrated feature to isolate individual cells for characterisation. It is the perfect tool to be used together with new single cell characterisation assays currently being introduced on the market.ImpactThe innovation will provide an effective, accurate, fast and cheap characterisation of CTCs in a single device, enabling pathologists and clinicians worldwide to deliver personalised medicine and cancer treatment targeted the exact mutation of the individual patient’s cancer form. CytoTrack expects that the innovation can reduce cancer deaths by 10%. In EU alone this would reduce the productivity loss with >€10bn per year and treatment costs with >€12.5bn.ProjectThis phase 1 project will investigate 1) collaboration with labs, 2) regulatory conditions for first markets, and 3) prepare for clinical trials. The overall innovation project will enable CytoTrack to be the first on the market to offer an integrated diagnostic platform for routine isolation and characterisation of metastatic cancer cells in blood, enabling personalised therapy targeting the exact profile of the cancer form.Customers and marketThe CTC technology market was $3.7bn in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a bioengineered basement membrane to enhance the performance of blood-contacting devices' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Each year, over 10 million of transitory and permanent blood-contacting devices are implanted worldwide, playing a crucial role in addressing cardiovascular diseases and providing life-sustaining support. However, despite their widespread use, sub-optimal biocompatibility still represents a major challenge, compromising safety, efficacy, and durability. Up to 70% of patients experience device-related hemocompatibility issues, significantly affecting their quality of life. To mitigate these risks, antithrombotic drugs are commonly prescribed, yet these systemic treatments come with severe complications, including postoperative bleeding, stroke, and hemorrhage. To address these limitations, material surface modification strategies have been explored to improve the hemocompatibility of blood-contacting devices, with a particular emphasis on promoting stable endothelialization. Among these approaches, physical modifications, such as surface patterning, are considered superior to biological and chemical functionalization because they offer a long-lasting performance, without degrading or losing functionality over time, unlike conventional surface coatings. Despite the continued interest from both industrial and academic research, there are no clinically available bioengineered substrates that integrate mesoscale and microscale surface features able to promote and maintain stable device endothelialization that can ensure long-term resistance to thrombus formation. In this proposal, we aim to optimize and validate HemoStratum, a bioengineered substrate fabricated by our proprietary processing technology. By integrating electrodeposition and photolithography, HemoStratum leverages on both microfibers and meso-patterns identified to promote endothelial cell proliferation and str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Palladates Venture' under Horizon Europe.

assistant: **Concept**

The discovery of high-temperature superconductivity in cuprates gave rise to a wide field of research in condensed matter physics. After many decades of searching, superconductivity in a nickelate was reported for the first time in 2019. This gave rise to what some have called the ""nickel age"", providing a family of compounds analogous to cuprates that may shed some light on these fascinating materials.Now, in 2024, we see the need to open a new research front to this decades-long enigma of high-temperature superconductivity. In this project, at the frontier between physics and chemistry, we aim to synthesise and study a new family of palladium-based materials, analogous to the already studied cuprates and nickelates. We plan to apply new ideas to synthesise these compounds and tune their properties. We will also use different techniques to analyse and understand the physics of these oxides and ultimately be able to observe superconductivity in the palladium family. The results we obtain will certainly help in our understanding of the phenomenon of high-temperature superconductivity in any scenario. However, if superconductivity is also observed in any of these materials, we could be looking at the advent of a new age, which we could call the ""palladium age"".""


**Keywords:** Transition metal oxides, palladates, high-pressure synthesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Big Picnic:Big Questions - engaging the public with Responsible Research and Innovation on Food Security' to be submitted under Horizon 2020.

assistant: **Abstract**

Ensuring the availability of and access to sufficient safe and nutritious food is a key priority that impacts all EU citizens and Horizon 2020 has therefore identified food security as one of the major challenges to be addressed. BGCI, an international network organisation will work with botanic gardens, experienced informal science centres with research expertise in food and food plants, alongside other key organisations to implement the BigPicnic project. This project builds, through the co-creation approach and public debate, public understanding of food security issues and enables adults and young people across Europe and in Africa to debate and articulate their views on Responsible Research and Innovation (RRI) in this field to their peers, scientists and policy makers. The project involves the delivery of low-cost, co-created outreach exhibitions on food security, using the metaphor of a picnic basket; the exhibition will include information, activities and participatory events that engage a broad range of target audiences (adults, schoolchildren and families). Building on audience engagement and data captured from these initial, locally held, exhibitions, the project will run science cafés in publicly accessible and informal engagement areas as well as in botanic gardens, again capturing public views on RRI and food security. The final phase of the project will consolidate the findings of the public engagement to produce two key publications, a report articulating public opinion and recommendations for RRI on food security and a co-creation toolkit that will build capacity for engagement in further science institutions across the EU. A number of case studies on RRI will be provided to support the EU RRI toolkit currently under construction. It is expected that th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Healthy crop, Healthy environment, Healthy finances ... through Optimization' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Pulverizadores Fede is a technology leader in the production of agricultural machinery for vertical crops found, for example, in orchards and vineyards. As such, we are well positioned to contribute to resource-efficient eco-innovative food production, which is not only good for the environment but is also key for the agricultural sector’s competitiveness with a clear European dimension. Cropland covers almost 25% of the EU (4.4 million of Km2) and most of that area is subject to phytosanitary treatment. With the two year H3O project, we bring a completely new generation of plant protection product application devices (sprayers) to market, reducing the amount of product that is released into the environment by 50%. Further, the fine grain adaptation allows to save 38.5% diesel. For a small farmer with 10 hectare of vertical crop this results in product and fuel savings worth 4630 Euros annually. Moreover, the project is meeting key requirements of the EU Directive 2009/128/EC on sustainable use of pesticides and is in line with the food chain industry standard GLOBAL G.A.P.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bulgarian centre of solar energy' under Fifth Framework.

assistant: **Concept**

The objectives of the BGCSE are:l. Rise of the scientific and technological level of clean energy" production.2. Promoting the rapid implementation of solar systems and installations.3. Improvement of education on and understanding of the potential and wide application of solar energy use and its significance for human welfare and the environment within the framework of sustainable development."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Study of cis/trans proline isomerization as a novel regulatory mechanism of protein function' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function. Recently a growing body of evidence has emerged supporting the role of prolyl cis-trans isomerization as a new intrinsic molecular regulatory mechanism with important consequences for protein function. Proline is the only amino acid in proteins that depending on the value of the ω angle of the peptidic bond can adopt two completely different conformations (cis or trans), which can have important consequences for protein structure. Furthermore, the slow inter-conversion between these two conformations provides a regulatory mechanism of protein structure and enzymes (named peptidyl prolyl isomerases, PPIases) able to catalyze the isomerization exist. The recent discovery of the phospho-specific PPIase Pin1 implied a new regulatory role for this family of enzymes. Pin1 has been shown to be involved in the control of cell-cycle, growth factors and apoptosis and its deregulation to be implicated in cancer, asthma and neurodegenerative diseases. However, the study of the exact effect of cis/trans proline isomerization in protein function and the role of PPIases (specifically Pin1) in biological networks has been deeply hampered by the intrinsic nature of this non-covalent modification which can be safely defined as the most subtle of the ones currently known. Here we propose to adopt a Chemical Biology approach in order to study some of the unanswered questions about Pin1 difficult to address through more traditional methods. We will try to elucidate Pin1’s mechanism of action, the different biological function between cis and trans conformations of its substrates and develop a new method to monitor its activity. We expect this