RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards Hydrogen and Electricity Production with Carbon Dioxide Capture and Storage' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

DYNAMIS responds to the target of Preparing for large scale H2 production from decarbonised fossil fuels including CO2 geological storage". The main objective is to prepare the ground for large scale European facilities producing hydrogen and electricity from fossil fuels with CO2 capture and geological storage. 29 legal entities have established DYNAMIS, encompassing 4 European fossil fuel end users, 3 fossil fuel producers, 6 technology providers, 1 engineering- and 1 financing group together with 14 R TD providers. The group gathers the critical mass required to undertake such a task. DYNAMIS is designed as an element of the HYPOGEN project, part of the European Commission´s Quick-Start Programme within the Initiative for Growth. The HYPOGEN project in cludes as an interim step the construction of a large-scale facility for the production of hydrogen and electricity from decarbonised fossil fuels with CO2 storage. DYNAMIS is the first step on that route, designed to rank the options and to reduce the ris k in development of a fullscale pilot plant post-2008. DYNAMIS is organised as an integrated project (IP). The RTD activities are structured in 5 sub projects that directly meet the stated objectives of the Work Programme: * SP2 Power plant and capture tec hnology * SP3 Product gas handling (H2 and CO2) * SP4 Storage of CO2 * SP5 Planning and pre-engineering of plants * SP6 Societal anchorage of a HYPOGEN demonstration DYNAMIS will, in compliance with the stated objectives of the Work Programme: * deliver ap propriate information and provide recommendations for potential technologies, plants and sites for large scale hydrogen production with CO2 management from fossil fuels at a level intended for pursuing the pilot phase of HYPOGEN * provide a framework for l egal,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanotransduction mediating cell adhesion - towards cell-inspired adaptive materials' (CellInspired) under Seventh Framework.

assistant: **Objectives**

Adhesion is a key event for eukaryotic cells to establish contact with the extracellular matrix and other cells. It allows cells to quickly adapt to mechanical changes in their environment by either adhesion reinforcement or release. Understanding and mimicking the interplay between adhesion reinforcement and release could result in novel cell-inspired adaptive materials. In order to ultimately be able to transfer functional principles of cell adhesion to a next generation of biomimetic materials, we will elucidate the biophysics of cell adhesion in response to external force. We have already obtained important results that have provided new insights into cell adhesion. For example, we have found that the nanoscale spacing of adhesion sites controls cell adhesion reinforcement. With the project proposed here I want to advance our understanding of cell adhesion by generating a comprehensive model of mechanotransduction-mediated cell adhesion. Therefore, my group will develop new force measurement methods based on atomic force microscopy and 2D force sensor arrays that allow for a systematic investigation of key parameters in the cell adhesion system, including the concept of cellular mechanosensing. My hypothesis is that there is a transition between adhesion reinforcement and release as a function of external mechanical stress, stress history, and the biofunctionalization of the adhesive surface. Transferring our biophysical knowledge into materials science promises new materials with a dynamic adaptive mechanical and adhesion response. This transfer of biological concepts into cell-inspired materials will follow the construction principles of cells: the proposed material will be based on polymer fibers that are reversibly cross-linked and reinforce adhesion upon mechan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Competition between the enteric pathogen Clostridium difficile and the commensal members of the gut microbiota for mucosal sugars', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Clostridium difficile is a Gram-positive, anaerobic bacterium that relies on the disturbance of the normal gut microbiota to colonize the human intestinal tract and cause infection and disease. In the last decade new strains of C. difficile have emerged to cause outbreaks of increased disease severity and higher recurrence and mortality rates. C. difficile infection (CDI) is becoming refractory to the conventional antibiotic treatments and probiotic-based approaches are viewed as promising alternative therapies to effectively treat CDI. The development of such bacterial-based treatments requires the identification of the mechanisms by which the commensal members of the gut microbiota are able to eradicate C. difficile, as well as of the identity of the members of the gut microbiota that orchestrate those mechanisms. Since nutrient competition is an important mechanism by which the colonic microbiota suppresses the growth of many enteric pathogens, I focus here on competition for limited nutrient sources, such as the gut mucosal sugars N-acetylglucosamine (GlcNAc) and sialic acid, as a mechanism by which the members of the gut microbiota can eradicate C. difficile. I will investigate in detail the importance of GlcNAc catabolism, both alone and in combination with the catabolism of sialic acid, for C. difficile expansion in the gut. Furthermore, by combining stable isotope probing (SIP) and fluorescence in situ hybridization (FISH) with high resolution secondary ion mass spectrometry (NanoSIMS) I propose to identify commensal members of the gut microbiota that can efficiently catabolize these mucosal carbohydrates in vivo and to evaluate the ability of the identified organisms to outcompete C. difficile. Thus, this work will contribute to elucidate the mechanisms by whic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Promoting of Polish participation in GMES' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The specific support action proposal aims at the promotion of participation of Poland in GMES. The establishment of a single national point called GMES Information Centre (GIC) will concentrate information, advisory and support activities related to GMES in one institution, what should result in an increased efficiency and synergy. The project focuses on the following priorities:- Support for participation of Polish institutions in GMES thematic projects- Support for growth of user segment of GMES-related projectsThose priorities would be served by the different actions: Establishment of working contacts between Polish institutions and GMES thematic projectsconsortiaDissemination of information on the potential existing in Poland in the field of Earth Observation Promotion of and support for use of EO data by public users (including policy makers) on central level Promotion of and support for use of EO data by public users on regional and local level Dissemination of information and advisory activities Successful undertaking of the project should result in:- Establishment of working relations between Polish institutions and GMES consortia- Improvement of knowledge about potential existing in Poland in the field of EO, mainly among GMES community.- Creation of conditions for utilisation of EO data by public authorities, including convincing decision-makers about potential benefits- Facilitation of use of EC structural funds for that purpose- Facilitation of introduction of projects based on utilisation of EO data Improvement of knowledge about potential benefits that may be derived from use of EO data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Aquatic Pollution from Light and Anthropogenic Noise: management of impacts on biodiversity' (AquaPLAN) targeting Horizon Europe.

assistant: **Abstract**

Recent decades have seen dramatic increases in our understanding of Light and Noise Pollution (LNP) impacts on aquatic biodiversity. These impacts are globally widespread and occurring in all aquatic ecosystems from lakes and rivers to the seafloor. A variety of technologies and policy interventions are also now available to mitigate LNP impacts in aquatic ecosystems. Yet, numerous knowledge gaps exist that if addressed would substantially improve our understanding of the prevalence and impacts of LNP, and our ability to manage them. There remain critical gaps in our understanding of the combined occurrence and impacts of LNP across the breadth of aquatic ecosystems, particularly at large spatial scales and over long-time frames. While numerous abatement options exist, pathways to achieving their effective implementation remain unclear.AquaPLAN is an interdisciplinary pan-European consortium that are world leaders in the fields of aquatic light and/or noise pollution. AquaPLAN aims to quantify the combined impacts of LNP on aquatic biodiversity across European seas, lakes, and rivers, and facilitate the implementation of empirically sound strategies for managing these pollutants through novel interdisciplinary approaches. AquaPLAN will: i) provide a comprehensive review of the state of the art on the impacts of LNP on aquatic biodiversity; ii) assess perceptions of LNP impacts and the need for their management across key stakeholder groups; iii) quantify the combined impacts of LNP on the conservation status of biodiversity in aquatic habitats; iv) identify the mechanisms leading to individual and combined impacts of LNP on aquatic biodiversity; v) explore innovative interdisciplinary solutions to prevent and mitigate LNP impacts on aquatic biodiversity; vi) build an in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hacking the ribosome to map virus-host associations' (VirHoX) targeting Horizon Europe.

assistant: **Abstract**

High throughput sequencing and metagenomics have deepened our understanding of viruses in nature, yet linking viruses to their hosts remains a challenge, hindering our knowledge and applications. The VirHoX project aims to overcome this by ""hacking"" the ribosome to map virus-host associations. Leveraging a critical moment in the infection cycle of all viruses, the translation of viral genes into proteins by the host cell, we will uncover concealed relationships between viruses and their hosts, providing a universal tool for virus-host pairing. This novel approach, VirHo-seq, involves ligating host ribosomal RNA with viral mRNA during translation in infected cells using engineered enzymes, followed by high throughput sequencing to reveal virus-host pairings. Our interdisciplinary consortium of academic and industrial experts in microbiology, protein engineering, gene editing, viral genomics/transcriptomics and law, will develop and then prepare the commercialisation of VirHo-seq, envisioning legislative and analytical frameworks to maximise its impact. This technology will significantly help tackle current challenges, such as those posed by emerging pathogens, ecological disruptions, and climate change. Our approach aligns with the EIC Work Programme objectives, demonstrating feasibility on model organisms before validating on relevant samples, addressing the ""engineered living materials"" challenge.""


**Keywords:** virus-host associations, environmental viromics, ribosomes, mRNA-rRNA ligations, recombinant proteins, protein engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of IFN-β in mitochondrial homeostasis and impact on Parkinson Disease' (IFNBetaMito) targeting Horizon 2020.

assistant: **Abstract**

Parkinson disease (PD) is the most common progressive neurodegenerative movement disorder. Two prominent pathological features are associated with the neurological lesions: the appearance of cytoplasmic inclusion bodies called Lewy bodies, and defective mitochondria. Despite recent progress in understanding the pathogenesis of PD, no curative treatments are available. The host laboratory has very recently found a novel mechanism leading to PD: mice lacking interferon (IFN)-β (Ifnb–/–) or its receptor (Ifnar–/–) display spontaneous neurodegeneration and experience behavioral deficits resembling PD. In particular, Ifnb–/– neurons show mitochondrial defects with accumulation of defective mitochondria. The overall goal of this proposal is to determine the molecular mechanisms of mitochondria homeostasis controlled by IFN-β and how this is involved in PD. 1. I will characterize precisely the mitochondrial defects found in Ifnb–/– mice using a combination of 3D and 4D microscopy and biochemistry analysis. 2. I will identify the protein dynamics involved in the IFN-β regulation of mitochondria homeostasis, using proteomic analysis complemented by microscopy and biochemical studies on engineered cells. 3. I will determine the importance of this pathway in the physiopathology of PD by studying the impact of IFN-β on mitochondria in murine brains and using engineered mitochondrial transfer.The accomplishment of this project will provide new insights into IFN-β regulation of neuronal homeostasis and highlight novel drug targets for future therapy development against PD. The project will be supervised by Pr Shohreh Issazadeh-Navikas, a world-leading expert in the field of IFN-β signalling pathway. Through this work, I aim to broaden my scientific expertise by acquiring numerous tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High speed bi-directional laser cutting and creasing of fast moving carton-board for packaging' (1998-2002) under Fifth Framework.

assistant: **Objectives**

European SME packaging producers (around 6000 in EU) are under a continuous pressure of often-powerful (multinational) clients to meet constant changes in packaging designs and features. Current process equipment (rotary and punch tools) have limitations due to long delivery times of tools for design changes (e.g. 4 months for rotary tools) and high costs (50.000 Euro per design change) all leading to extremely low flexibility. The objective of the Hi-SLIDE project is to develop new laser-based process equipment for fully automated in-line cutting and creasing (a fundamentally new approach in the total processing system of packaging). Goal is to obtain complete freedom of (intermediate) design changes and to ban completely the problem of wear of the cutting tools. These innovations will result in radical improvements in flexibility, reduced time to market (50-80%), cost reduction (70%), high speed (300 metres/minute), accuracy (100% repetitively) and waste reduction (50%).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transport of Engineered Nanomaterials across the blood-brain-barrier' to be submitted under Horizon 2020.

assistant: **Abstract**

Engineered nanomaterials (ENMs) offer unique potential for innovation in a diversity of applications, but have also been linked to potential adverse effects on human health and biota. A particular concern is the accumulating evidence implicating ENMs in neurotoxicity, with a potential mechanism involving crossing the blood brain barrier (BBB) and then directly or indirectly acting on the central nervous system. Currently, two key questions pertain to this uncertainty: (1) What conditions favour ENMs crossing the BBB? This is most likely related to the physicochemical properties of the ENMs but the current understanding is limited and inconclusive, primarily due to limited or irreproducible characterisation of ENMs. Therefore, a systematic investigation on the BBB-penetrating ability and association with the intrinsic properties of ENMs is urgently needed. (2) What is the fate of ENMs within and beyond the BBB? i.e. the deposition, translocation, and transformation of ENMs after crossing the BBB. Given that the accumulation of ENMs in BBB might be low, localizing the ENMs in the system would be a challenging task, especially for ENMs with high elemental backgrounds (e.g., C-based and Fe-based ENMs). Thus, novel approaches are urgently needed to enable a breakthrough in our understanding of ENM ability to cross the BBB and trace their path beyond. Project NanoBBB proposes combining novel labelling techniques with an on-a-chip brain model and in vivo experiments enabling a uniquely novel approach to solve this problem. This project will allow us to systematically understand the behaviour and fate of certain ENMs in brain and contribute to safer design of ENMs. The ER brings her extensive biological expertise to the host lab, which in turn offers world-class analytical and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Promotion of plasticity as a treatment for neurodegenerative conditions'.

assistant: **Innovation**

Neurodegenerative diseases all cause damage to the circuitry of the nervous system, with loss of connections, axons and neurons. The loss can be gradual, as in Alzheimer’s disease, rapid as in stroke, or intermediate as in the delayed neuronal loss after stroke. Following damage, the nervous system is able partially to compensate through the formation of alternative connections and pathways, a process known as plasticity. Adults are therefore able to regain considerable function after stroke, and to compensate for the synapse and cell loss of Alzheimer’s disease until it reaches a critical level. Children undergo a period of enhanced plasticity in most parts of the CNS at the end of development, known as critical periods. During these periods their ability to compensate for damage to the CNS is in many cases much greater than in adults. The overall concept behind this application is that restoration of the function in neurodegeneration can be achieved through plasticity (the formation of new functional connections, withdrawal of inappropriate connections, modulation of synaptic strength). Promoting increased plasticity in selected parts of the adult nervous system back to the level seen in children is a powerful method of enhancing recovery of function in animal models. Plasticity-promoting treatments could therefore be beneficial in a wide range of conditions that damage the CNS.  The PLASTICISE project integrates scientists from four scientific areas 1) Development of methods to promote plasticity 2) Development of models of neurodegenerative disease 3) Imaging of plasticity at the macro and micro level 4) Study of recovery of function through plasticity in human patients with brain disorders. The concept that unites the partners is the belief that treatments that enh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated cost-effective construction process for transport infrastructures, based on a flexible industrialisation of FRP components' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Polymer based manufactured components for construction applications have been designed, developed and demonstrated in European projects such as HP FUTURE-Bridge, SAFEFLOOR and MEGAWIND. The results are very promising regarding customer requirements, quality, technical and economical feasibility and the favourable impact of using this kind of composite-based components in terms of sustainability, safety and quality of life. However, there is a need to industrialise the whole construction process of the Fibre Reinforced Polymers (FRP) components in order to really achieve these results. Further integration of the entire supply and value chain is needed, as well as the development of a high technology for design and manufacturing of FRP components, to transform on-site construction to off-site manufacturing. The overall objective of the Trans-IND project is to develop a cost-effective integrated construction process that will enable the maximum capability of industrialisation of components for transport infrastructures (road and pedestrian bridges, underpass, containing walls, acoustic and safety barriers) using polymer based materials (carbon fibre, glass fibre ). It will be demonstrated, as a pilot case, for components of a bridge (beams and preslabs) due to a higher complexity in the bridge components manufacturing and assembly compared to other applications.