RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Virtual institute on bio&microencapsulation sciences and technology' (VIBMST).

assistant: **Concept**

Microencapsulation aims to include active components in microspheres. The number of microencapsulation technologies is very extensive, making it difficult to select the proper process for a specific product. Fifteen partners coming from 9 countries will start the European V.I. but the partnership will be extended to 30 to 40 members plus a large number of associated researchers. The V.I. will act as a communication platform, central information system, expert moderator and unique portal for the microencapsulation field. The V.I. will provide information survey, training, consulting and collaborative project management. All this actions will help entrepreneurs to select the right process and to find the most appropriate partners, and then to succeed, in the optimum conditions, a microencapsulation business.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Commercial feasibility of an anti-bacterial treatment'.

assistant: **Concept**

Multidrug resistance of pathogenic bacteria has become a serious threat to public health. The need to develop novel technologies to combat the evolution of bacterial drug resistance is clearly a matter of public concern and urgency. The consequences of AMR include (i) reducing our ability to treat common infectious, resulting in prolonged illness and a greater risk of complications; (ii) patients remaining infectious for longer due to ineffective treatments, making them more likely to pass infections on to others; (iii) compromising advances in modern medicine (such as organ transplantation or chemotherapy) due to risk of infection; and (iv) increasing economic burden on health care systems, families, and societies. This project aims to assess the commercial viability of an alternative approach to this problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Trading and post-trading'.

assistant: **Objectives**

Two of the main functions of financial markets are to discover equilibrium prices, thus providing useful information to the economy, and to enable investors to realize mutually beneficial trades. For markets to serve these goals, it is necessary that i) investors be matched efficiently and trade at prices accurately reflecting relevant information, and that, ii) transactions be executed without counterparty or payment failure. These conditions can fail due to informational frictions (limited rationality, search costs or adverse selection) or opportunistic behaviour.I will study the following issues: How can different trading and post-trading mechanisms mitigate or worsen these problems? Are financial market equilibria information constrained optima? Is there a role for public policies? Is algorithmic trading economically and socially useful? Can investors and institutions’ opportunistic behaviour generate counterparty risk? How do informational frictions affect market liquidity? What are the welfare properties of such trading institutions as electronic order books, high-frequency algorithmic trading, margin deposits, and central clearing counterparties?To study these issues, I will rely on theoretical models, and empirical analyses of financial markets data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Adaptive Control of Soft Robots for Personalized Upper-limb Rehabilitation with Machine Learning' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

ACORN-PURM (AC) develops a next-generation upper-limb rehabilitation system that leverages adaptive control of soft robots and ML to provide personalized therapy based on individual patient needs, significantly improving user engagement and recovery outcomes. Stroke, spinal cord injuries, and other neurological conditions cause upper-limb disabilities, affecting millions globally and leave them with impairment. It creates a significant burden on healthcare systems. Current rehabilitation approaches often lack personalization, leading to decreased motivation and suboptimal outcomes. AC addresses this critical gap by developing an innovative solution that is: more engaging, data-driven, and patient-specific system that tailors therapy to individual needs, enhancing patient engagement and potentially accelerating recovery. The system has the following unique features: Gamified exercises enhance motivation and adherence to therapy schedules, real-time adjustments based on user intent and fatigue levels optimize therapeutic benefit, soft robotics ensure patient comfort and safety during rehabilitation sessions. Existing robot-assisted therapies are often rigid, uncomfortable, and lack real-time adjustments based on individual progress, offering one-size-fits-all approaches. Relying heavily on subjective therapist evaluations for progress tracking can be repetitive and tedious, leading to patient dropout and possess limited ability to anticipate user intentions. AC advances the field by 1) Developing Adaptive Controllers with ML that will adjust assistance levels based on individual real-time data for a truly personalized experience, 2) Utilizing DL for Advanced Movement Recognition and Assessment to analyze user data for objective assessment of subtle improvements and compen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Semantic integrAtion and reasoning Framework for pharmacovigilancE signals Research' to be submitted under Seventh Framework.

assistant: **Abstract**

Adverse drug effects endanger patients’ safety and cause considerable extra healthcare costs. The procedures of drug surveillance and drug harm prevention are studied by pharmacovigilance. Several Information Technology (IT) methods are currently employed for conducting research as regards identification of pharmacovigilance signals. The current project (SAFER) will elaborate on exploiting and complementing evidence obtained from various types of existing pharmacovigilance signal sources through: (a) the semantic harmonization and mediation among the respective signal detection methods, and (b) the development of signal aggregation and reasoning mechanisms that will enable knowledge fusion of the obtained outcomes, introducing overall an integrated, semantic approach for obtaining and managing knowledge on pharmacovigilance signals. The proposed approach is particularly applicable, since signal generation is characterized by incomplete knowledge and uncertainty in the results obtained from all types of signal detection methods, thus, a synthesis of all possible signal sources is necessary. SAFER aims to properly detect true associations and minimize false positive findings, which are the major drawbacks of most signal detectors currently available, so as to reinforce the reliability and completeness of pharmacovigilance signals. Major expected results of SAFER constitute: (a) a generic knowledge model that will address the heterogeneity of the available signal detectors via their semantic harmonization, (b) an advanced decision support service for medication error prevention based on the introduced reasoning scheme, and (c) a semantically-enriched IT framework for integrated pharmacovigilance research. SAFER will be conducted in the INSERM - U872, Eq20 - group, a centre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EPOS Implementation Phase', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The nations of Europe are distributed around some of the most complex and dynamic geological systems on the planet and understanding these is essential to the security of livelihoods and economic power of Europeans. Many of the solutions to the grand challenges in the geosciences have been led by European scientists – the understanding of stratigraphy (the timing and distribution of layers of sediment on Earth) and the discovery of the concept of plate tectonics being among the most significant. Our ability to monitor the Earth is rapidly evolving through development of new sensor technology, both on- and below-ground and from outer space; we are able to deliver this information with increasing rapidity, integrate it, provide solutions to geological understanding and furnish essential information for decision makers. Earth science monitoring systems are distributed across Europe and the globe and measure the physico-chemical characteristics of the planet under different geological regimes. EPOS will bring together 24 European nations and combine national Earth science facilities, the associated data and models together with the scientific expertise into one integrated delivery system for the solid Earth. This infrastructure will allow the Earth sciences to achieve a step change in our understanding of the planet; it will enable us to prepare for geo-hazards and to responsibly manage the subsurface for infrastructure development, waste storage and the use of Earth’s resources. With a European Research Infrastructure Consortium (ERIC) to be located in Rome (Italy), EPOS will provide an opportunity for Europe to maintain world-leading European Earth sciences and will represent a model for pan-European federated infrastructure.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In Meso Crystallogenesis of GPCR-protein ligand complexes' in the context of a Seventh Framework call.

assistant: **Objectives**

G protein-coupled receptor (GPCR) proteins are the single largest drug target, representing 30% of all marketed drugs. All GPCRs share a basic structural core of seven transmembrane alpha-helical domains. In spite of this similarity, GPCRs have evolved to be extremely versatile receptors for extracellular messengers as diverse as biogenic amines, purines and nucleic acid derivatives, lipids, peptides and proteins, odorants, pheromones, tastants, ions like calcium and protons, and even photons. Due to their significant effect on human physiology and disease, it is crucial to understand from a structural biology perspective, the molecular basis for the interaction between a GPCR and its ligand. The recent success in the structure determination of the Beta2-adrenergic GPCR and the adenosine A2a GPCR using the in meso crystallization methodolgy paves the way for further advances in structure determination of GPCR structures. As of today, there is no structural information available that helps us in understanding the molecular basis of interaction between a GPCR and its protein ligand. In this application, we propose to perform structure-function studies on two GPCRs, CXCR4 and Formyl Peptide Receptor, that are activated by the polypeptides SDF1 and f-MLF respectively. We propose to use in a synergistic fashion two novel methodologies, the BACMAM system and in meso crystallography, to express, purify and crystallize complexes between CXCR4-SDF1 and FPR-fMLF. Information obtained from the structure determination of these complexes would go a long way in helping us understand the molecular mechanisms responsible for the signal transduction properties of GPCRs that are activated by protein ligands. In addition, this information would also help us in designing and developing bet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Chemical Design of Smart Molecular/2D Devices for Information Technologies' (2D-SMARTiES) under Horizon Europe.

assistant: **Objectives**

The final goal of 2D-SMARTiES is to develop a new generation of magnonic devices based on hybrid molecular/2D heterostructures in which a precise control of the spin dynamics can be achieved by external manipulation of stimuli-responsive molecules. With this aim in mind, the project will establish an efficient theoretical and computational framework to guide the synthetic efforts towards the creation of low power consumption and highly tunable nanodevices for information technologies using a chemical approach.  The recent emergence of 2D van der Waals magnetic materials provides unprecedented building-blocks to transmit, storage and process information using spin waves, whose quanta are called magnons, at the limit of miniaturization. We will exploit the potential of switchable organic and spin crossover molecules to act as emitters, modulators and detectors of magnons at interfaces formed by this class of molecules and 2D antiferromagnets. This will open a versatile route based on smart molecules to face some of the current challenges in magnonics. In concrete, we will provide: (1) a more profound understanding of the hybridization of molecular orbitals on magnetic surfaces, as well as the effect of these hybridized states on the spin dynamics of 2D magnets; (2) a software package to model magnon dynamics in hybrid materials; (3) a deep analysis of strain-magnon coupling effects due to the thermal or light-induced spin switching in spin crossover systems deposited on 2D materials; (4) an efficient quantum transport code accounting for spin-orbit torque effects to understand the enhancement of properties in the 2D material when interfaced with a topological insulator; and (5) the creation of novel devices as a proof of concept. We envision the birth of a new interdiscip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'DIGital traNsport In and for socieTY'.

assistant: **Innovation**

DIGNITY will delve into the digital transport eco-system to grasp the full range of factors that might lead to disparities in the uptake of digitalised mobility solutions by different user groups in Europe. Analysing the digital transition from both a user and provider’s perspective, DIGNITY will present the challenges brought about by digitalisation, and design, test and validate the DIGNITY approach, a novel concept that seeks to become the ‘ABCs for a digital inclusive travel system’. The project will build the approach step by step and provide a methodology to frame the digital gap in metropolitan/regional contexts, considering all elements of the digital transport ecosystem: the institutional framework (macro level), the provision of digital mobility (meso level) and the needs of end users (micro level). It will then combine proven inclusive design methodologies with the principles of foresight analysis to examine how a structured involvement of all actors - local institutions, market players, interest groups and end users - can help bridge the digital gap by co-creating more inclusive mobility solutions and by formulating user-centred policy frameworks. DIGNITY will demonstrate the approach in 4 pilots: Barcelona (ES), Tilburg (NL), Ancona (IT) and Flanders (B). The evaluation of DIGNITY’s potential and the impacts generated in the pilots will lead to conclusions and policy recommendations for wider uptake. Practical applications for designing inclusive digital transport in the form of the DIGNITY toolkit will help public authorities, transport operators and private providers consider the needs and requirements of all users in their decision-making processes. To fully exploit DIGNITY’s research results and the knowledge acquired to a broad audience, a Learning Com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Warning and Mitigation Technologies for Travelling Ionospheric Disturbances Effects' under Horizon 2020.

assistant: **Concept**

Travelling Ionospheric Disturbances (TIDs) constitute a threat for operational systems for which the ionosphere is an essential part (i.e., radio systems) or for which the ionosphere is fundamentally a nuisance (i.e. GNSS based systems and applications). The overarching objective of TechTIDE is to design and test new viable TID impact mitigation strategies for the technologies affected by the TIDs and in close collaboration with operators of these technologies, to demonstrate the added value of the proposed mitigation techniques which are based on TechTIDE products.  To achieve this main goal, it is necessary to address the following specific objectives:i. Improve understanding regarding the physical processes resulting in the formation of TIDs, and consequently to identify the drivers in the interplanetary medium, the magnetosphere and the atmosphere;ii. Define the impact of the TIDs on the space based navigation systems (mainly EGNOS services and N-RTK) and on ground-based HF communication and geolocation systems;iii. Develop improved methodologies, based on consortium partners’ algorithms, suitable to support for the first time the direct,real-time identification and tracking of TIDs over wide world regions;iv. Establish an operational system to issue warnings of the occurrence of TIDs over the region extending from Europe to South Africa, to estimate the parameters that specify the TID characteristics and the inferred perturbation, and provide all additional geophysical information to the users to help them assess the risks and to develop mitigation techniques, tailored to their applications;v. Work systematically with potential users to assess the functionality, reliability and efficiency of the TechTIDE services paving the way to its systematic exploitation from u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Rapid induction of passive immunity against weapons of bioterrorism using transformed GRAS (generally regarded as safe) microorganisms' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Weapons of bioterrorism, such as the toxin-producing bacteria Bacillus anthracis and Clostridium botulinum, pose serious threats to Western societies. Since no products are available that allow rapid vaccination, exposed populations would be completely unp rotected. Even if a vaccine could be developed, active immunization would require multiple doses. Thereafter, it would take many months to achieve protective levels of antibodies and vaccination could only be applied to selected risk-groups. We have recent ly developed a model system in which Lactobacillus, a GRAS microorganism, can be transformed with antibody fragment encoding vectors. This allows the expression of functional single- chain antibodies against mucosal pathogens in situ. These antibody fragme nts retain their biological properties in vivo and may mitigate or prevent disease. The aim of this project is to select and characterize Lactobacilli with different tropisms and to develop the vector system currently used into a food-grade transformation/ integration/cleaning system that allows simultaneous expression of multiple antibody specificities. Furthermore, we intend to clone the genes encoding the variable region from hybridomas producing neutralizing antibodies against protective antigen (B. anth racis) and botulinum toxins (C. botulinum). These will be introduced into the selected Lactobacilli and the resulting transformants tested for their protective capacity in animal models. Our approach, which falls outside the domains of the FP6 thematic pri orities, represents a completely novel system for the induction of passive immunity that can be rapidly applied to populations at risk (for example through the drinking water). The transformed Lactobacilli will colonize the mucosa in exposed individuals, a l