RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Precommercializing a Method For Inducing Muscle Fiber Formation For Industrial Meat Production' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The global population is expected to reach 9 billion mark by 2050 which will cause an increase of 70% on the global demand for food. However, if the global trends of meat and animal products consumption continue at the current rate, the global mean temperature will rise by over 2C despite the emissions of non-agricultural sectors being drastically decreased. Therefore, a growing need exists to develop more efficient protein production options. During embryonic muscle development, myoblasts proliferate and undergo differentiation, a multistep process which requires cell cycle withdrawal, initiation of a muscle specific gene transcriptional program, differentiation into fusion competent myoblasts, and ultimately cell-to-cell fusion to form nascent multinucleated myotubes that mature to form contractile muscle fibers. We have identified a novel signaling cascade, that is easily controlled by a small molecule inhibitor, leading to faster and more robust in vitro muscle formation than can be achieved with the conventional differentiation medium. This occurs through the induction of synchronous differentiation and ultimately enhanced cell-to-cell fusion of the muscle progenitor cells. The discovery of a signaling cascade which enhances myoblast fusion draws parallels to the needs of the newly established and ever-growing field of cultured meat, which builds upon the techniques used for decades in the in vitro study of myogenesis. The cultured meat industry is actively seeking ways to increase production efficiency in order to reach price-parity with the current meat industry. Therefore, taking advantage of processes that can speed up and enhance efficiency of myoblast fusion would facilitate this achievement. The goals of the PoC project are to improve the maturity of our ide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Researching Interoperability using Core Reference Datasets and Ontologies for the Virtual Physiological Human' (RICORDO).

assistant: **Concept**

The Virtual Physiological Human network represents an active and diverse community of biomedical scientists that studies human biology by computational means. This diversity is the basis for an impressive breadth of scientific approaches, and emergent technologies, as well as potentially shareable resources such as data and models. Although in principle, the resources generated are re-usable, in practice, few can currently be shared. A key reason for this disparity stems from the lack of consistent cataloguing, annotation and accessibility of VPH data and models (VPHDMs). The creation of a communal annotation strategy that supports the interoperability of VPHDMs across different biological scales (known as vertical integration), in such a way that is clinically relevant, is a fundamental goal for the VPH community. For this objective to be achieved, a community standard for the representation of multiscale biological entities represented across VPHDMs must be studied and tested carefully. To this end, this project will take a key step in prototyping a multiscale anatomy standard, and demonstrate its effectiveness in connecting patient specific radiological images to mathematical models of physiology, as well as to related genomic and molecular data. VPH data and model resources vary in type, complexity and accessibility. Therefore, the technical infrastructure that complements such an annotation strategy, and supports the interoperability of distributed VPH resources, will also be prototyped in this project.The outcome of this work will contribute a resource interoperability plan to the VPH's Toolkit Development Plan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spatial variations in the effective elastic thickness of the continental lithosphere - a combined forward and inverse modelling approach' (1994-1998).

assistant: **Innovation**

Research objectives and content This investigation will determine the best method to find the integrated strength of the lithosphere, common referred to as the effective elastic thickness or Te. A number of different forward and inverse modelling techniques have been applied in recent years for determining the Te for both the continents and the oceans. Discrepancie amongst the methods are particularly apparent for continental settings. This project would carry out comprehensive pilot study where estimates of Te from forward modelling will be statistically compared to those from inverse spectral techniques. The results will determine the best inverse method for large scale mapping lithospheric strength. This method will then be applied to Global data sets to re-evaluate and/or determine the structure of the continents, particularly Europe. Training content (objective, benefit and expected impact) This request for training would expose me to an excellent research team based in Oxford with a global database Interaction with the team would greatly further my research abilities and allow transfer of acquired skills back Ireland. This proposal will result in a Global re-evaluation of lithospheric strength arising from self-consiste forward and inverse methods. The results will be interpreted in terms of its relationships with temperature, stress indicators, composition and tectonics. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ScieNcE Together' (NET) under Horizon 2020.

assistant: **Objectives**

The goal of the NET project is to lay the foundation of a NETwork connecting research world and society, building a stable and empatic communication path among institutions, researchers and citizens, also thanks to the capillary physical presence of the partners in the territory, since the NET consortium is made by well-recognised public italian research and academic institutions. This network will offer a stable exchange path through which researchers can share their passion for science, their work and life with citizens, who, in turn will use the path to get the scientific viewpoint from their “informed neighbors”. Conveying this idea is the first step to build and plan a research-based society, by increasing the number of students taking up research careers. The path will be paved by using conventional and unconventional, online and offline communications tools, to reach every citizen, regardless of age, gender, cultural or economic conditions, even if particular attention will be devotaed at students and pupils. NET will bring researchers closer to the general public and increase awareness of research and innovation activities, increasing the public recognition of researchers, creating an understanding of the impact of researchers' work on citizens ́ daily life, promoting choices for a sustainable future. In fact the main theme of the project is the most relevant and global question of this millennium: the climate change, in order to give citizens information to be aware protagonists of collective political choices and correct individual behavior. NET European Researchers’ Night and related activities will take place in 16 italian cities (from North to South: Brasimone, Chioggia, La Spezia, Ozzano, Civitavecchia, Fiumicino, Frascati, Grottaminarda, Monte Porzio Cato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Real-time hydrogen-storage monitoring via energy-efficient deep learning' under Horizon Europe.

assistant: **Concept**

The use of renewable hydrogen as green fuel and energy storage was deemed key to achieve the European Green Deal. However, its large-scale storage is still facing significant challenges. Measurement inversion via deep learning (DL) is a state-of-the-art approach used for underground storage-site detection and monitoring. However: 1) It requires a huge amount of training data; 2) DL training is expensive, and 3) There are no efficient and reliable DL techniques for multiscale electromagnetic measurement inversion.The goal of GEOLEARN is to guide hydrogen storage technologies by inverting subsurface multiscale electromagnetic measurements in real time using energy-efficient DL methods. For this purpose, GEOLEARN will leverage mixed-precision (MP) computations to maximise energy- and cost-efficiency, and ensure scalability. GEOLEARN proposes to address the above challenges as follows: 1) Develop MP finite element methods (FEMs) that can rapidly generate large training data; 2) Design MP DL algorithms that can efficiently process huge databases during training and invert measurements in real time, and 3) Apply the new techniques to invert multiscale geophysical electromagnetic measurements and guide hydrogen storage.We will collaborate with industry to disseminate the project results and maximise exploitation, and the new methods will lead to high impacts in and outside academia.The host has extensive experience in DL methods for inverse problems in geophysics and FEMs, and already collaborates with relevant companies. The secondment host is expert in high-performance computing and FEMs, and the applicant is expert in MP methods for scientific computing. This multidisciplinary research team is essential for the success of GEOLEARN, and will enhance the applicant's knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cross-Sectorial observations of threat perceptions and research priorities in European Biological Homeland Security' under Sixth Framework.

assistant: **Concept**

The purpose of CORPS is to analyze biological security- and threat perceptions, and research- and development (R and D) values in order to strengthen cross-sector communication and knowledge-sharing between agencies in the field of biological homeland security in the EU. A more coordinated understanding of threat and security perceptions, assessments and priorities will lead to a clearer understanding of what R and D-activities are needed in order to optimize biological homeland security capabilities and societal preparedness in the EU. The project will be divided into four overall parts: 1. The project will map sectors and relevant agencies in the field of biological homeland security in order to establish a database of points of contact" at EU-level. 2. Using questionnaires, deep interviews and analysis of key documents the project will analyze security- and threat perceptions, and research values and priorities across the sectors. 3. On the basis of the analysis of security- and threat perceptions and R and D priorities, practices and needs, the project will set out recommendations on the optimal prioritization of R and D-activities related to biological homeland security in the EU. 4. The project will take steps to set up a permanent cross-sector network with a common database and website to share information on R and D-priorities, experiences and best-practices in biological homeland security. The Danish National Centre for Biological Defence (NCBD) is willing to co-ordinate this when the project period ends after three years. Thus, the project activities during the three year period can be viewed as a platform for a permanent biological homeland security network."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Transformation scenarios for boosting organic farming and organic aquaculture towards the Farm-to-Fork targets'.

assistant: **Objectives**

With the Farm-to-Fork Strategy (F2F), the EU has set targets of reaching at least 25% of the EU’s agricultural land under organic farming and significantly increasing organic aquaculture by 2030. The overall objective of OrganicTargets4EU project is to support the achievement of these targets.Based on an assessment of key drivers and lock-ins affecting the development of the organic sector, the project will set-up a multi-actor process to create possible scenarios for reaching the targets. The project is structured into two strands, which run from start to finish:•Production and Markets: the project will analyse where increases in organic farmland can be achieved, and the (socio-economic) impacts of these increases at the level of primary production, value chains and markets. The project will also provide evidence on the mechanisms that can drive demand for organic food and the impact of changing diets and food waste reduction on mitigating the reduced yields from organic production.•Knowledge and Innovation: the project will work towards an innovation ecosystem fit for achieving the F2F targets, recognising that the scale of the expansion envisaged will require a transformational approach. It will identify knowledge gaps and opportunities to strengthen advisory services. It will build capacity, and stimulate exchange of scientific and practice-oriented knowledge. Building on the CORE Organic network, it will increase and coordinate R&I investment for organic.OrganicTargets4EU will facilitate a multi-actor policy dialogue to assess the feasibility of the organic F2F targets and develop policy recommendations for the CAP, EU organic regulation, EU and national organic action plans, Horizon Europe, and horizontal legislation on inputs and public procurement. The policy re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Materials'.

assistant: **Innovation**

Recent developments in the area of large molecular systems have convincingly demonstrated that synthetic chemistry is now in a position to jump the gap between ingeniously designed model compounds and custom-designed practically useful materials. At the same time it is becoming progressively clear that novel practical or technological applications will only come within reach if these impressive synthetic strides are matched with a host of measurement techniques and characterisation experiments.In this context it seems natural to us to propose that an equal combination of selected synthetic chemists, physical and chemical experimentalists, and theoreticians, who - in different ways - have been devoting their research efforts to the study of large and complicated molecules, should form the constituency of the next meeting of the ESF Research Conference series Chemistry and Physics of Multifunctional Materials".The first highly successful meeting was held in Sept 97 under the title "Fullerenes in Context", followed by the "Taming Molecular Complexity" in Sept '99 and "Chemical Building Blocks for New Materials" in Sept '01. In "From Clever Molecules to Smart Materials"" we propose to explore the idea that if materials scientists are to develop organic materials that match or exceed the performance of the known and prospective inorganics, it will be necessary to make a systematic, coordinated effort across discipline boundaries. This requires scientists to: (i) assemble, characterize, measure, and model a whole range of variously derivatized systems according to a strategy that can only emerge if (ii) interactions between synthetic chemists, spectroscopists, theoreticians, materials scientists and industrial strategic researchers are enhanced. Targeted conferences such as t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel technology for the molecular characterization of habitats of intracellular pathogens and its use for the development of a live vaccine against Leishmaniases.' under Sixth Framework.

assistant: **Concept**

Many pathogens adopt an intravesicular lifestyle, but for most a detailed molecular description of their habitat and status once inside a host cell is lacking. A molecular understanding however would greatly advance fundamental knowledge of this lifestyle, allow directed functional characterization and facilitate the identification of novel targets for strategies of diagnosis and/or intervention. In many cases, our lack of knowledge is due to the currently inadequate technologies to purify infected compart ments to enable global, high resolution analysis e.g. by proteomics. The objective of this project is to:I) Overcome this technical limitation by developing a a novel, coloured approach to purify pathogen habitats based on fluorescence activated sorting. I I) Use this technology to characterize the habitat of the human pathogen Leishmania donovani to decipher the principles of its intracellular life. III) Apply this knowledge to develop an affordable live vaccine for clinical testing against the etiologic ag ent of visceral leishmaniasis that causes thousands of deaths each year.Transgenic mice will be generated that exhibit a green fluorescence-tagged endocytic pathway. The technology has the potential for a broad application in cell biology in general. The t ransgenic mice will provide primary host cells for infection with diverse, red fluorescence-coded pathogens. Here, these will be dendritic cells infected with red Leishmania donovani for characterization of the habitat and parasite molecular composition by proteomics. Parasite-derived molecules identified by this novel approach will be classified based on their topology and proteins secreted or surface exposed will be selected as candidate molecules for vaccine development. A live vaccine based on recombina nt S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing a surgical infection treatment to reduce amputations, healing times and hospital stays for diabetic foot patients' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

XTremedy Medical is a surgical ablation company founded in 2018 to commercialize technology treating deep wound infections, including Diabetic Foot Infections (DFI). Our pulsed field ablation (PFA) system is the first to deliver electrical currents non-invasively to achieve superior clinical outcomes including faster cure of infections, reduced surgeries and shorter hospital stays.The Problem:Deep tissue and bone infections are life threatening infections that affect a millions of Europeans every year.  Immunosuppressed patients are particularly vulnerable, with Diabetic Foot Ulcer Infections a leading cause of amputations in Europe. These patients are incredibly difficult to treat, requiring multiple surgeries, lengthy hospital stays and long-term antibiotics. In 20% of patients, an amputation is required to control the infection. Surgical intervention to remove infected tissue is the cornerstone of treatment but surgeons must balance removing infected material whilst preserving healthy tissue required for healing. Treatment Landscape:Current treatment modalities either only treat the surface of the wound or use mechanical forces to treat below the surface. Surface treatments fail as they leave infection below the wound bed untreated. Mechanical devices can cause more severe infections by damaging the integrity of the wound bed and propelling the infection deeper. As a result, these treatments are often ineffective, with 50% of patients requiring additional surgeries.XTremedy Solution:XTremedy Medical have developed a surgical device that delivers electrical signals through the wound. This device treats both the surface and below to zap any residual infection. The technology is non-thermal and preserves the integrity of the wound during treatment, helping reduce the ti