RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'HEAR-ECO Innovative Hearing Aid Research - Ecological Conditions and Outcome Measures'.

assistant: **Objectives**

In today’s ageing European population, hearing impairment is an increasing concern for public health and societal participation. The percentage of hearing-impaired people will rise from around 16% of the adult EU population now to around 40% in 2030. Hearing aid (HA) fitting is the most widely prescribed solution for hearing impairment. However, only around 30%-40% of adults with hearing impairment use HAs in daily life. One of the reasons for this is that methods used to develop and evaluate HAs are still not based on conditions in which HAs are actually used. Thus the potential of improved HA technology to meet the needs of individual users in their daily lives is acutely under-exploited. The science in HEAR-ECO will help to facilitate the paradigm shift which is needed to bridge the gap. Such a paradigm shift requires a new generation of hearing scientists that are able to integrate conventional Audiology with Motivational and Social psychology (motivation to listen, cognition), Psychophysiology (pupillometry, PEP, EEG), and HA technology. HEAR-ECO will train six ESRs capable of spanning these disciplines and translating their knowledge into innovative technological HA evaluation and development. The six ESRs will be trained through local training at academic partners in The Netherlands and the UK and secondment to one of the largest hearing aid manufacturers in the world in Denmark – and through network wide training, including an associated partner in Liverpool. The ESRs will be capable of developing and combining new tools and outcome measures for realistic everyday communication and translating this to innovative technological HA evaluation and development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Scribal Science: Naturalists' Paper Empire in France ca. 1660-1770' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

SCRIBSCIE seeks to understand the place of scribal practices and manuscript artefacts in the work of French naturalists between ca. 1660 and 1770, and especially their role in these scholars’ effort to gather a knowledge of the wider world’s nature. The aim is to measure the vibrancy of scholarly scribal labor in the age of print and well beyond epistolary exchanges. My overarching hypothesis is that manuscript culture shaped the ill-defined intellectual and social contours of both natural history and the naturalist’s persona, not the least in their global and imperial dimension: making and managing manuscript records of observations and data were imperial gestures through and through. In charting the hidden stories of taken-for-granted artefacts such as field notes, excerpt notebooks, plant catalogs, and sketches, as well as quotidian gestures such as notetaking, listing, drawing, arranging papers into folders, and moving archives from one location to another, this project asks about the social, political, and cultural implications of European scholars’ working methods at home and abroad in a context of colonial expansion. Mining principally the exciting and virtually untapped holdings of the Muséum national d’histoire naturelle (MNHN) in Paris, the project fits particularly well the first major professional objective of this action, namely to develop my career as an independent historian of science with a strong expertise in museum and library curatorship. This last aspect in particular will be achieved through close collaboration with the MNHN and a secondment to Università di Bologna: such trans-sectorial transfer of expertise will materialize in a workshop, a special issue, and an exhibition. The second major professional goal is strengthening my experience in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Application of alternative technology to produce lightweight electronic power packages and encapsulations for hybrid semiconductor devices' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

A generic semiconductor package was defined in terms of design features and performance criteria. The development of aluminium alloy based powders, that could be subjected to Metal Injection Moulding (MIM) and sintered, was restricted to powders that contained 70% silicon carbide particulate. A proprietary binder system was developed to a point that facilitated the Metal Injection Moulding of trial samples of the Metal Matrix Composite (MMC). Technical delays were experianced in the development of a powder system that could be processed successfully by MIM and sintered to give a material that satisfied the required material properties, ie: with the presence of excessive porosity - which would not provide a hermetic encapsulation, and control of the material shrinkage to ensure accuracy of the finished near net shape part. These delays were incurred through an under appreciation of the high level of fundamental materials research required to progress the state-of-the-art to achieve the technical objectives that would result in the production of demonstrator near net shape encapsulations. By the mid-term point the delays in the original project programme were such that the objectives were not attainable within the time and budget limitations of the Craft scheme and the decision was taken to close the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Automated shuttle for augmented port performance' (ASAPP).

assistant: **Concept**

Objectives and content Background problematic: The evolution of the maritime transportation of containers is favouring, due to technological constraints, the ports with very high traffic volume, because they are the only ones that are able to economically justify, due to economy of scale, the enormous investments in yard areas and machinery that are currently required to grant the hourly productivities that are requested by the Shipping Lines. The consequence is a continuous ageing of the medium-sized ports that are typically present in the European scenario, that is, of the ports that, being located inside the cities, cannot have enough possibilities of expansion. The solution to make minor ports more attractive is to develop innovative technological solutions that allow to reach, even with the small space available, quay performances that are better or equal than those of the hub ports". One of the main inefficiencies of the current terminals is the transfer of the containers from yard to quay crane and vice versa. The reasons of this inefficiency are related to the use of man-driven vehicles, within narrow lanes and with inevitable bottleneck points, in which, without an automatic computer control, the management of the jobs and of the queues produces remarkably high inefficiencies (the logistic problem is to manage a flow of 200 vehicles/hour within a quay that is 30 meters wide). An electric vehicle, capable of moving with satisfying speeds during the straight paths and smart enough to be able to steer automatically, travelling on dedicated overhead paths will be the right answer to the logistic needs even when little space is available. Project objectives: To transfer the containers from the quay crane to the stocking yard, by using the new logistic concept based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hyperpolarized ultra-low field (ULF) magnetic resonance to design next generation functional contrast agents' (ULF), addressing dissemination and exploitation.

assistant: **Impact**

Nuclear magnetic resonance (NMR) is a powerful technique that is widely applied for chemical analysis, structural biology and for medical imaging. Despite its versatility, NMR is inherently insensitive. To overcome sensitivity challenges, hyperpolarization methods were developed that enhance NMR signals by over 10,000-fold. Hyperpolarized molecules have mainly been used in standard high-field imaging as contrast agents to directly observe metabolism. Most of the contrast agents have a traceability of up to 3 minutes until the hyperpolarized signal is depleted, limiting the scope of applications. Contrast agents that are observable for longer time periods (> 10 minutes) hence promise new opportunities to probe physiological function in vivo, exceeding the state-of-the-art. Long hyperpolarization storage is especially possible in many chemicals species at ultra-low magnetic fields (< 10 millitesla), more than 1000-fold lower than typical NMR systems.  My overarching goal is to introduce a novel concept of functional contrast agents using the advantages of ultra-low field (ULF) NMR spectroscopy. I will show that these contrast agents are even of interest for cancer diagnostics. In addition to a long traceability, different structural information of molecules become available in the ULF regime that I am planning to explore to design contrast agents: Changes of electron-mediated couplings between nuclear spins of different elements can be determined with unprecedented precision in the ULF regime. I have already extensively worked on this challenge and have constructed ULF-NMR devices and analyzed how molecules change their coupling patterns under ULF conditions. In addition, I have made great progress in designing molecules that can be hyperpolarized and the polarization sto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Common Language Resources and Technology Infrastructure' (CLARIN).

assistant: **Innovation**

The ultimate goal of CLARIN is the construction and operation of a shared distributed infrastructure that aims at making language resources and technology available to the humanities and social sciences research communities at large. The preparatory phase will pave the way for implementation along 4 dimensions: Funding and governance: The aim is to bring together the funding agencies and to work out a ready-to-sign draft agreement between the funding agencies in the participating countries about governance, financing, construction and operation of the infrastructure. Technical: The technical objective is to provide a detailed specification of the infrastructure, agreement on data and interoperability standards to be adopted, and a running, validated prototype based on these specifications. The validation should cover technical, linguistic and user aspects. Language: For the validation the prototype will be populated with a selection of language resources and technologies for all participating languages. The objective is to deliver a sufficiently populated, and thoroughly tested prototype that demonstrates the adequacy of the approach for all participating languages. User: In order to fully exploit the potential of what language resources and technology have to offer to the humanities and social sciences communities we will: (i) make an analysis of current practice in the use of language technology in the humanities in order to establish the needs; (ii) launch and monitor typical humanities projects in order to validate the prototype and its specifications; (iii) create awareness in the humanities and social sciences communities of the potential of the use of language resources and technology to improve or innovate their research; (iv) bring together the humanities and l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of functionalized nanostructured polymeric membranes and related manufacturing processes for water purification' to be submitted under Seventh Framework.

assistant: **Abstract**

The NANOPUR-project aims at leveraging on promising bottom-up technologies to develop intensified water treatment concepts based on nano-structured and nano-functionalized membranes as well as nanofilm deposition for micropollutants and virus removal.Major research needs targeted include the preparation of membranes with selective properties at the nanoscale able to maintain high permeability with relatively low driving force. The ultimate “challenge” exists in the creation of artificial membranes able to perform separations with the selectivity of biological membranes while having mechanical strength and productivity of state-of-the-art artificial membranes. The project will advance the knowledge in this area by developing scalable approaches to prepare nano-structured membranes characterized by a selectivity towards pathogens of up to 99.99999 % and towards micropollutants up to 99 %, while retaining a permeability higher than  current ultrafiltration membranes in addition to functional stability equal to existing commercial membranes. The envisaged research activities will involve the preparation of polymeric nano-structured membranes characterized by well-controlled architectures and functions for supramolecular recognition for removal of viruses, hormone disruptors, endotoxins and antibiotics from water. For the generation of affinity and catalytic sites on membranes, molecular imprinted polymers and atmospheric pressure plasma treatment will be explored. The technological developments will be carried out along two different technology paths each targeting at a different aspect of the water treatment process. A first research path will focus on the reduction of membrane fouling thereby enhancing the flux while the second research path targets the removal of micro-p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Integration of Nano- and Biotechnology for beta-cell and islet Transplantation'.

assistant: **Concept**

The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model. The project will develop1) novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans; 2) develop and validate the application of state-of-the-art imaging technologies facilitating the provision of new regenerative therapies to preclinical large animal models and patients; 3) directly contribute to the opening of a new market sector for i) imaging equipment (SPECT, PET/MR, optoacoustic imaging in preclinical large animal models and patients), ii) nano-imaging molecule supplies (nanomolecules allowing multimodality imaging of specific cell types with high sensitivity), iii) validated transplantable in vitro differentiated human beta-cells and porcinexenotransplant islets thus will reinforce the European healthcare supply chain for regenerative medicinal products. The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area. The consortium of 5 SME and 3 Academic partners is coordinated and driven by the industrial partners from the field of nanotechnology, imaging and stem cell technologies, providing a perfect match and unique combination addressing the scope and expected i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Polycomb repressor interactions in relation to the mammalian epigenome' (PRIME).

assistant: **Concept**

In mammals Polycomb group (PcG) repressors play a central role in maintaining cell type specific gene expression patterns in stem cells and through differentiation and development. Accordingly, deficiencies in the Polycomb system are important in disease, notably in several types of cancer.   Although it is established that the effector function of PcG proteins is in large part attributable to intrinsic histone modification activities, the mechanisms that target PcG proteins to defined loci remain poorly understood.  A number of different models have been proposed in order to account for PcG targeting to CpG islands at the promoters of target genes, the inactive X chromosome, and in defined circumstances, to pericentric constitutive heterochromatin. Our recent studies, and those of others, have highlighted that underlying chromatin state and DNA methylation play an important role, and based on this we have developed a general model that can account for PcG localisation at all target loci.  The central aim of this proposal is to test the general model and to determine the mechanisms by which underlying chromatin states dictate PcG factor binding. In a series of integrated experiments we will define chromatin modifications on mononucleosomes purified from PcG target loci, determine the activity of major PcG complexes in vitro using nucleosome templates assembled with recombinant histones/histone variants bearing specific chromatin modifications, and, using a novel photo-cross-linking strategy, define, at the atomic level, interactions of PcG complexes with chromatin templates in vitro. Finally, based on our findings we will establish de novo PcG target sites in cells and/or disrupt preexisting PcG target sites. These studies will help to define the fundamental mechanisms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A pan-cancer diagnostic platform based on nanobiotechnology and machine learning for simple and accessible early cancer detection' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cancer is the second highest cause of death in the EU, with more than 1.3 million deaths attributable to cancer each year. Early detection of cancer is crucial to increasing the chances of survival for patients. For example, the average cancer survival rate is 83% when caught early and only 17% when diagnosed at an advanced stage. This is compounded by the difficulty and expense of screening for early stage cancers. Beyond expensive and specialist whole body imaging techniques such as MRI, there is still no commercially available general test for detecting any type of cancer before symptoms present themselves. Staggeringly, 52% of cancer deaths are due to a lack of preventative tests. Metachip, from ConquerX, is a revolutionary pan-cancer diagnostic platform that enables early-stage detection of the 10 most common types of cancer from a single, simple blood test. The platform consists of a reading device, disposable chips coated with a proprietary nanocomposite, and a diagnostic software suite powered by cutting edge artificial intelligence. The Metachip test is cost effective, fast (one hour to results), and does not require specialist analytical techniques or lab facilities. By delivering the Metachip platform, ConquerX aim to make early-stage detection of cancer available to every hospital in the EU and worldwide. During the phase 1 feasibility study, ConquerX will establish a sound go-to-market strategy and supply chain, and will draft further development plans. During the second phase of the innovation project, ConquerX will optimise the diagnostic platform, scale-up manufacturing, perform clinical validation activities with partner hospitals and gain regulatory approval.