RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Minimizing environmental pollution and enhancing soil sustainability through the use of p efficient crop plants' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The contribution of terrestrially-derived sources of N and P to the nutrient content of surface and ground-waters is increasing annually across Europe resulting in wide scale pollution incidents (e.g. eutrophication). The blame for many of these P driven eutrophication events has been firmly placed on agriculture (Powlson, 1998). The general rise in freshwater nutrient loads has been primarily attributed to the long-term application of fertilizers and additions of p minerals to livestock rations. The effect of this surplus has been to increase the total amount and availability of P in agricultural soils. Until recently, this has been considered highly beneficial, however, this large surplus of soil P is now acting like a slow release pollution time bomb. To prevent continued pollution therefore requires intervention strategies such as (1) a reduction in, understanding of, and optimization of P applications to agricultural land, and (2) a more efficient use of native soil P by crops. The key aim of the proposal will be to focus on critically assessing the efficiency of previously hypothesized, but untested, plant mechanisms for enhancing soil P uptake. We will use cultivars of wheat with known differences in phosphatase and organic acid excretion. These will be grown under high and low soil P conditions and the levels of organic acids and phoshates in the soil determined by micro sample-capillary electrophoresis and micro sample-fluorimetry. We will also patch label soil with inorganic K233PO4 or organic P (33P labeled dead roots) and artificially raise phosphatase and organic acid levels through direct injection of citrate, oxalate, malate, and acid and alkaline phosphatases. Plant 33P uptake will then be assessed over time and the critical phosphatase and organic acid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Analysis of the cellular origin of breast cancer'.

assistant: **Objectives**

Breast cancer is a heterogeneous disease, which includes many different types of cancers with diverse histopathologies, genetic and genomic variations, and clinical outcomes. Pathological states of the breast, such as pre-neoplastic lesions and carcinomas, retain aspects of cellular composition observed in the normal breast. It is not clear if the heterogeneity of breast cancer reflects the same hierarchical pattern of the normal tissue. In particular, the question remains as to whether specific molecular pathways establish the subtype of breast cancer or whether different cell types within the breast hierarchy become transformed and give rise to each tumour subtype. Currently, one of the major limitations in the field consists of a lack of experimental model systems that correctly recapitulate the pathogenesis of human breast tumours.The main aim of this project is to study the cellular origin of breast cancer. In order to use a model which more closely recapitulates the human pathogenesis of breast cancer in a relatively short time frame as compared to traditional transgenic mice models, we will develop a novel system which will be used to address several important questions. The model will provide a powerful tool to dissect the contribution of oncogenes and targeted cells to the development of specific types of cancer. The system generated will also provide a relatively rapid breast cancer model which will allow us to study the contribution of selected factors, already described in the host laboratory to be important in mammary gland development and possibly tumourigenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The JMA diesel aero engine', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

This project addresses a new concept in light aircraft power plants. In 1993 JMA Propulsion Ltd. won one of the UK Department of Trade and Industry's SMART Awards for its compression ignition aero-engine of low weight and high specific power output of a modular design. The configuration was that of a turbo charged compact diesel engine which reduces atmospheric pollution, noise, fuel consumption and fire risk, increases range, provides a high power: weight ratio and significantly reduces torsional vibrations. During the two years following this award, the company has used its experience gained to design a range of modularised two stroke diesel aero engines and it on this that the current proposal is based. While the main components are generally ot a tried and tested design, the configuration is entirely new and is justified by the significant direct benefits of reduced total product and operating costs, reduced fire risk to personnel and reduced environmental intrusion by noise. The level of torsional vibrations associated with conventional diesels has prevented them being harnessed easily to an aeroplane propeller due to uneven twisting action of the crankshaft and consequent risk of propeller failure. The configuration of the JMA Ashton engine concept results in a considerable weight saving due to the engines inherent balance and the reduction of unbalanced loads reaching the crankshaft. The JMA Ashton engine is well suited to running on renewable fuels, such as vegetable oils, due to the very high cylinder swirl engineered into the design which increases thermal efficiency and reduces emissions. Engine emissions are reduced by ensuring that there is always a surplus of oxygen compared to amount of fuel being injected. The first mechanical demonstrator engine will ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Towards the application of MOrphing MOvables in AEROstructures'.

assistant: **Innovation**

The framework of the project is to support the development of an active morphing winglet demonstrator within the Airframe ITD. The current project will deliver elements necessary for the future industrialisation of the technologies involved in morphing movables. These elements concern (I)- a comprehensive material behaviour characterisation and prediction method, specific for the requirements coupled with this application, subsequently called ‘Part A’,(II)- a production method necessary to demonstrate the application of a novel pressurised cell actuation system subsequently called ‘Part B’.Both parts are complementary, though these will support two types of demontrators. The first part is meant to realise a large step towards qualification of the morphing technology on focussing on materials able to realise morphing defomation in an existing concept, while the second one focuses on a technology integrating all aspects related to morphing movables, around an innovative fluid based control system, named FAMoUS.


**Keywords:** Morphing,  Movables,  Thermoplastic,  Fluid actuation,  Winglet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Glacial sculpture in Mars’ ancient megachannels' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Mars is a hyperarid, global cryosphere, and likely has been for over 3 Gyr. However, during the so-called early Mars period 4-3.5 Gyr go, water flowed within thousands of valleys, in crater lakes, producing ancient deltas, building ice sheets, and possibly ponding in oceans. Surface liquid water was stable on Mars coinciding with the origin of life on Earth. However, this early benign climate collapsed with the continued loss of Mars atmosphere in the Hesperian period, ~3.5-3 Gyr ago. Outflow channels, megacanyons among the largest erosive landforms in the Solar System, date from this time. The largest one, Kasei valles, is so vast that the volumes of water involved in its formation were an important fraction of Mars total water inventory, and its outflow could have filled an ocean on the martian lowlands. In the current view, Kasei Valles was formed by a megaflood sourced from the catastrophic release of a near-surface aquifer, building on the basis of terrestrial analogue comparisons. This work aims to challenge this view. In this project I will explore the hypothesis that Kasei Valles was eroded by an ice stream, a region of channelized, fast-flowing ice within an ice sheet, based on its scale, location, and geomorphology, and reinvestigate the origin of other outflow channels under this perspective. Drawing from novel fluid dynamic simulations, analogue field work, geological mapping, and climate modelling, I will test the Ice flood hypothesis, which if correct would radically change our understanding of Mars transitional Hesperian climate, the nature of its hydrological cycle, and the possibility of a Hesperian ocean. Outflow channels hold a key for understanding the collapse of Mars early climate and hydrological system, the end of global conditions able to suppor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Schooling, Training and Transitions : An Economic Perspective'.

assistant: **Objectives**

The primary objective of our proposal is to bring together the work an experiences of European economists who have invested the field of education and training. The TSER (area II) offers a unique opportunity to exploit the wealth and diversity of European institutions and data for the benefit of a growing expertise in comparative analysis and of a deeper understanding of the mechanisms which have shaped schooling and training systems, and labour market transitions (from school to work, and from job to job), somewhat differently across countries. We propose a theoretical and empirical investigation of three related topics: (1) A comparative analysis of schooling systems (sub-area II-1 of the TSER) (2) The transition from school to work (sub-area II-3 of the TSER) (3) Training and labour market flexibility (sub-area II-3 of the TSER). Our proposal consists in a RTD project and a thematic network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Improving the selectivity of kinase inhibitors: Characterizing binding mechanisms of inhibitors targeting inactive states and allosteric sites'.

assistant: **Concept**

Kinase proteins are key to signaling in eukaryotic cells, so it is not surprising that their dysfunction has been implicated in human diseases such as cancer and inflammatory disorders.  As a result, kinases have become important targets for drug discovery.  The majority of kinase inhibitors bind to the ATP-binding site, which is highly conserved among the different kinases.  In order to increase inhibitor selectivity toward a desired target kinase, the focus has turned to developing inhibitors which bind to inactive conformations or allosteric sites.The techniques frequently used to study inhibitor binding such as X-ray crystallography and docking are limited because they only sample a single structure.  In reality, a protein is characterized by an ensemble of structures.  Free energy calculations can sample many different conformations and provide a clear picture of the mechanisms of inhibitor binding.  Since straightforward molecular dynamics simulations suffer from a time scale problem we use a novel computational technique, metadynamics, to enhance sampling.  Using metadynamics calculations we propose to investigate the binding mechanisms of inhibitors which target the inactive conformation and allosteric sites.We focus on two proteins which are targets for cancer therapy: p38 mitogen-activated protein kinase and Abl.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A pilot line of antibacterial and antifungal medical textiles based on a sonochemical process' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Hospital-acquired (nosocomial) infections are a major financial issue in the European healthcare system. The financial impact of these infections counteract medical advances and expensive medical treatments by increasing the length of hospital stay by at least 8 days on average per affected patient, hence adding more than 10 millions patient days in hospitals in Europe per year.  The statistics on patient safety in the EU show alarming tendencies : - 1 in 10 patients are affected by hospital-acquired infections  - 3 million deaths are caused by hospital-acquired infections  An active infection control program of patients and personnel and hygiene measures, have proven to significantly reduce both the number of infections and hospitalisation costs .  The SONO project directly addresses the above problems by developing a pilot line for the production of medical antibacterial textiles.  The pilot line will be based on the scale-up of a sonochemical process developed and patented at BIU laboratories. The pilot line will use a sonochemical technique to produce and deposit inorganic, antimicrobial nanoparticles on medical textiles, e.g. hospital sheets, medical coats and bandages. Sonicators are used industrially for heavy and light duty cleaning, for water disinfection and for sewage treatment. It is also used in the food industry for emulsification and drying. The proposed concept based on one step sonochemical process to produce nanoparticles and impregnate them as antibacterial factors on textile is novel and does not exist on an industrial scale.  The concept has already been proven (and patented ) on a lab scale where sonochemistry was applied to impregnate nanoparticles in a single-step process. It was demonstrated that due to the special properties of the sonochemical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spin conversion, logic  storage in oxide-based electronics' (SPICOLOST).

assistant: **Innovation**

Nowadays, among of the main challenges in the rational and efficient use of the energy, the energy harvesting, energy saving and energy conversion are key points in the research and application of electronic devices. The optimization of device performances making them more powerful with less energy consumption while keeping an affordable production cost is mandatory. The present project will address those challenges by means of designing suitable materials for implementing on devices able to reduce the energy consumption. Nanotechnology, Oxide and Superconducting Spintronics will be the competitive edge technologies triggering the interconnection and cooperation between international labs and technological companies, from Europe and overseas by means of sharing knowledge, cross-linked working and innovation, gaining capacities towards this mission. SPICOLOST project will tackle this challenge with two parallel approaches: i) with suitable heterostructures with high efficiency conversion of thermal energy in electricity, taking the advantage of harvesting, the so called thermoelectric thermopile device based on Seebeck and Spin Seebeck Effects; and ii) producing multicomponent nanostructured materials for magneto-electronic and superconducting devices capable of fast signal processing minimizing the energy dissipation by control the magnetic switching, and then consuming less energy. It is expected to produce advances in experimental fabrication processes, better control of interface properties of hybrid heterostructures and explaining them with suitable theoretical framework that conduct to novel discoveries due to the synergy between Superconducting and Spintronic.


**Keywords:** Thermoelectrics, Artificial Multiferroics, hybrid Heterostructures on Semiconductors, DFT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Developing Natural Language Processing and machine learning algorithms for the most comprehensive knowledge base to speed up diagnosis of rare disease patients' to be submitted under Horizon 2020.

assistant: **Abstract**

Collectively, rare diseases affect the lives of an estimated 30 million people across the European Union. The majority of rare diseases have a genetic origin, are chronic, highly disabling and life threatening. As a consequence, rare diseases pose a substantial medical burden for patients and an economic burden for society and healthcare systems. Correct diagnosis is highly challenging due to the rarity and sheer number of rare diseases. As a result, it takes an average of five to six years for patients to get their definitive diagnosis which can lead to serious consequences for their health. Mendelian is an innovative start-up with a mission to speed up diagnosis of rare disease patients by developing intelligent clinical decision support tools. For this, we have launched Mendelian’s search engine where medical professionals receive a ranked list of rare diseases and causative genes based on a patient’s symptoms entered. Building on the technology and knowledge gained during the development of Mendelian’s prototype search engine, we now aim to develop a highly detailed and comprehensive rare disease knowledge base that will improve the accuracy of our search engine and support the development of an automated scanning platform. For this, Mendelian is searching for a highly specialised PhD with expertise in state of the art methods in clinical Natural Language Processing (NLP) and Machine Learning (ML) so that features that are useful for diagnosis can be extracted and processed from medical literature and electronic health records in an automated fashion. Developing a comprehensive rare disease knowledge base in house is highly challenging but would have huge benefits by providing us with the flexibility to adjust and optimize NLP pipelines to optimally meet the needs o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'GoLexic: Transforming intervention for dyslexic children'.

assistant: **Concept**

GoLexic is an app that helps children with dyslexia and reading challenges improve their reading and writing skills thanks to an innovative, accessible, effective and affordable solution. It leverages a structured teaching approach developed for dyslexic learners, and uses speech recognition to drive reading practice and assess children's skills and challenges. This in turn drives the personalisation of the programme for each child. This combination of speech recognition and personalisation is a differentiator for GoLexic compared to other digital learning programmes for children with dyslexia. The goal is to scale personalised reading intervention so that parents and teachers have easy access to a robust tool that helps children improve their literacy skills.


**Keywords:** edtech dyslexia SEN literacy speech recognition personalisation