RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The evolution and function of fish TRIM E3 ubiquitin ligases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

FishTRIM aims to study the evolution and function of the TRIM family of E3 ubiquitin ligases in fish. This family has undergone several clade-specific expansions across the fish phylogeny, with single-copy mammalian TRIMs frequently present in large numbers in fish genomes. TRIM E3 ligases and their direct interactions with viral proteins are key in host-pathogen relationships, and several fish TRIMs have been associated to antiviral responses. Additionally, positive selection has been observed in fish TRIM protein domains involved in protein-protein interactions and pathogen recognition. This suggests that this family of fish E3 ubiquitin ligases may act as an immune mechanism against specific viral pathogens, and therefore the repeated independent expansions of the TRIM repertoire in fish could be the result of an arms race between fish and viruses. To address these questions, FishTRIM will focus on understanding the function of this family in fish, and their potential co-evolutionary interactions with viruses. Recent advances in the fields of functional genetics and genomics, such as single-cell technologies and genome editing, allow us to interrogate gene function at unprecedented scale and resolution. Nonetheless, a phylogenomic approach will be fundamental to determine potential functional overlap across independent expansions, and selection patterns in the context of TRIM protein domains will contribute to illuminate the function of the expanded TRIM repertoire. FishTRIM aims to deliver frontier knowledge on the biological significance of the different fish TRIM expansions, with potential to revolutionise our understanding of fish immune systems and the evolution of the ubiquitination machinery. FishTRIM will also explore the role of TRIMs in resistance to viral
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced solutions for assuring the overall authenticity and quality of olive oil' (OLEUM).

assistant: **Concept**

The OLEUM project will generate innovative, more effective and harmonized analytical solutions to detect and fight the most common and emerging frauds and to verify the overall quality of olive oils (OOs). By a core group of 20 partners from 15 countries OLEUM will undertake RESEARCH ACTIVITIES based on the development of IMPROVED and NEW ANALYTICAL METHODS by targeted and omics approaches with the aim: i) to detect new markers of the soft deodorization process; ii) to discover illegal blends between OOs and other vegetable oils; iii) to control OO quality (e.g. freshness); iv) to improve the organoleptic assessment with a Quantitative Panel Test, based on current official methods, and supported by tailored reference materials for better calibration of the sensory panels coupled with rapid screening tools to facilitate the work of the panelists. The most promising OLEUM solutions will be subjected to VALIDATION in conformity with internationally agreed standards by peer laboratories. OLEUM will recreate a realistic “deodorization scenario” by producing tailored, soft deodorized OOs by lab-scale and up-scaled pilot plants to apply analytical solutions to known samples. Substantial KNOWLEDGE and TECHNOLOGY TRANSFER activities will be envisaged to aid in implementation of: a) a web-based easily-accessible, scalable and constantly updated OLEUM DATABANK, containing all the information from OLEUM research and other reliable international sources, will be available for download data and spectra and to help achieve satisfactory harmonization of analytical approaches among control laboratories; b) the OLEUM NETWORK of relevant OOs stakeholders to maximize the impact of proposed analytical solutions. Finally, a robust dissemination strategy by the OLEUM project aimed at effectiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Are HPV vaccines ‘evolution-proof’? Multilevel evolutionary ecology of human oncoviruses', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

There is a threat that evolutionary responses can render vaccines ineffective, as illustrated by the emergence of the increasingly virulent Marek Disease Virus strains in poultry following vaccination campaigns. Assessing the ‘evolution-proof’ nature of vaccines targeting human viruses is challenging because it requires an understanding of the epidemiology, the within-host ecology and the evolutionary potential of the virus. To date, most investigations into the spread of vaccine-resistant strains are theoretical and are rarely constrained by data.We propose a novel alliance between evolutionary ecology and clinical research to assess the risk of vaccines selecting for resistant or virulent strains. Human papillomaviruses (HPV) and their vaccines provide an ideal study system. However, the scope of the project is wider and encompasses other DNA viruses. The project is divided into three parts. In Part A, we will decipher HPV within-host dynamics in genital infections. By combining mathematical modelling and longitudinal patient data, we will be able to parameterise within-host models and compare them. In Part B, we will jointly analyse host, virus and genital microbiota diversity using a community ecology approach to understand the infectious process. These results will be integrated into evolutionary epidemiology models allowing for diverse infections. In Part C, we will estimate virus substitution rates and use the results from Parts 1 and 2 to develop a multilevel analysis of HPV evolution in response to vaccination. We will also tackle more general questions related to the evolution of the virulence of human oncoviruses.A major asset of the project is the collection of clinical data in order to address a major public health issue using ideas and methods from evoluti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of Membrane Dynamics on Immunological Responses' in the context of a Seventh Framework call.

assistant: **Objectives**

The cellular plasma membrane is composed mainly of lipids and proteins. The bioactivity of the plasma membrane (such as the activation of receptors) is not only triggered and influenced by protein-protein or lipid-protein interactions, but also by bulk properties of the membrane such as the order or packing of lipids. In this project, I aim to understand how lipid packing influences membrane related processes in immunology such as T-cell signaling or antigen presentation. It is believed that lipid packing may have an important role in membrane-related immunological processes by concentrating various key molecules in a specific part of the membrane, thus constituting a catalytic platform to initiate signaling. However, numerous important questions remain, some of which I would like to pursue during my postdoctoral period using novel tools on model membranes and living cells: Is there any heterogeneity in lipid packing in the plasma membrane of T-cells or antigen-presenting (primary) cells? How does a variation in lipid packing effect the compartmentalization of key-proteins involved in T-cell signaling and antigen presentation, and how does this variation and compartmentalization effect functionality? Following that, I would like to develop an in-vitro lipid-protein vesicle system to model important characteristics of this aspect of immunology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of Chemically & Thermally Resistant Nanofiltration Membranes'.

assistant: **Objectives**

At the end of the project two new nanofiltration membranes were prepared in pilot scale. One system is especially developed for the seperation of oil/solvent mixtures (Torlon(REG) support membrane) while the other system is desingned for acqueous systems (PAN support membrane). Different types of coating have been carried out and the resulting membranes were characterised for their chemical and thermal stability as well as for their nanofiltration properties. In all cases the membranes were characterised for their chemical and thermal stability as well as for their nonofiltration properties. In all cases the membranes fulfil the properties required in the proposal. The mechanical stability tests showed that the membrane top-layer was vulnerable to puncture and abrasion by metal and other hard surfaces but sufficiently stabel to contacts with polymers. Construction of the spiral wound elements later in the project confirmed these results by showing that no extra precautions, besides the normal, need be taken to prevent mechanical damage. In case of the oil/solvent seperation new chemical stable spiral wound modules were fabricated too. They have been used with the new membranes for evaluation studied and economic calculations.Objectives and content The EC market for ultrafiltration, nanofiltration and reverse osmosis could grow significantly, if one shortcoming of the current membranes could be overcome. This is the lack of stability against many chemicals (e.g. organic solvents), particularly at elevated temperatures. The few chemically and thermally resistant membrane types which are on the market are either too expensive for most applications (ceramic membranes) or their molecular cutoff is too high for many applications. Proposed is to develop low cost solvent and te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Renewable Electricity-based, cyclic and economic production of Fuel' (EcoFuel), addressing dissemination and exploitation.

assistant: **Impact**

The collaborative project EcoFuel addresses the Topic “Development of next generation renewable fuel technologies from CO2 and renewable energy (Power and Energy to Renewable Fuels)” under the call Building a low-carbon, climate resilient future: Secure, clean and efficient energy. EcoFuel develops and demonstrates a novel thorough process chain that significantly improves the energy efficiency for production of synthetic fuel out of CO2 and water using renewable energy. The process chain comprises a) the supply of CO2 from the atmosphere via a novel direct air capture approach, b) direct electro-catalytic reduction of CO2 to C2/C3 alkenes at close to ambient temperatures, and c) thermo-catalytic liquefaction of alkenes, upgrading and fractionation into transport fuels. The direct electro-catalytic CO2 reduction to hydrocarbons offers greatly enhanced efficiency potentials compared to Power-to-X technologies downstream of water electrolysis and at the same time, reduces process pathway steps. Process performance will be validated by in-depth impact assessment. The EcoFuel approach will bring together chemists, physicists, engineers and dissemination and exploitation experts from 4 universities/research institutions, 2 SMEs and 3 industries, innovatively joining their key technologies to develop and exploit a novel complete process chain, based on the power of electrochemistry to deliver truly green (CO2 neutral) fuels with an unprecedented overall energy efficiency. Within 36 months project duration, the EcoFuel technology will undergo a thorough material and component R&D programme and together with its significant industry involvement this project will be set on unique path toward new technology developments up to TRL 4 that will have lasting impact on the European re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Protecting threatened river fish against predation' (ProtectFish) targeting Horizon Europe.

assistant: **Abstract**

Freshwater ecosystems are heavily impacted by human activities and climate change. Overall, at least 37% of Europe's freshwater fishes are threatened at a continental scale, and 39% are threatened at the EU level. This is one of the highest threat levels of any major taxonomic group (DG. Environment, 2011). Many species of river fish are in a very poor conservation status and even those that are protected by eg. the Habitats Directive, are not regularly monitored and documentation of the population trend and status is often lacking. A recent great increase in predation pressure has further increased pressure on river fish, even in healthy, restored or least-impacted areas. In the EU, predation may be the main reason for widespread loss of populations of Habitats Directive listed grayling (Thymallus thymallus). There is a genuine and widespread concern  among managers and stakeholders regarding protection of wild populations of river fish, as grayling, from unsustainable predation pressure. The conflicts involving fish protection and predation have been intense in most member states for decades and despite protective measures, including culling (Birds Directive article 9-derogations), the conflicts have remained intense. ProtectFish aim to investigate the monitoring and protective measures of Habitat Directive-listed river fish species, answering Area A of the call. We will develop and test protective actions, using cormorants (Phalocorax carbo sinensis) and grayling as a case. Small- and large scale field experiments will be conducted to measure the effect of relieving cormorant predation pressure on fish populations. We will examine the background for the conflicts, by estimating the current population status of cormorants and grayling in EU as well as quantify the cul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'African Research and Innovative Initiative for Sickle cell Education: Improving Research Capacity for Service Improvement', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Overarching Objective for this consortium is to establish an inter-agency and multidisciplinary staff exchange programme between researchers, technical and administrative staff interaction within EU institutions as well as reaching out to non-EU countries in Africa, Lebanon and US in order to foster sharing of best practice in Newborn Screening, diagnosis and treatment of Sickle Cell Disease (SCD) leading to improvement in overall disease outcome. Using implementation science strategies for this consortium to foster partnerships and the establishment of patient database, registries and a sustainable service for people living with the disorder.Primary Objectives:- To evaluate the prevalence of sickle cell disease among populations in consortium member countries and identify specific haemoglobin genotypes and phenotypic presentations;- To establish laboratory diagnosis and quality assurance systems for population screening and setting up of SCD national prevention programmes;- To test the feasibility for establishing newborn and early infant screening for SCD in consortium participants;- To establish treatment protocols for common complications -acute and chronic pain, stroke, infections, severe anaemia as well as transition from paediatric to adult care, health promotion strategies and nutrition.In order to achieve these objectives, we designed the following WPs:Scientific Coordination and Project Management Implementing eHealth technologies to support a Newborn screening programme in EU, African Countries and Lebanon.Improving laboratory diagnosis and quality assurance systems for population screening.  Newborn SCD screening, screening for neurocognitive complications, clinical care and antibiotic prophylaxis Enhancement of SCD management through training in molecul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Inflation in String Theory - Connecting Quantum Gravity with Observations'.

assistant: **Concept**

This project aims at predicting the energy scale of cosmological inflation and the strength of the inflationary gravitational wave signal from string theory. Observations of the cosmic microwave background (CMB) temperature fluctuations have drastically changed cosmology into quantitative science. The results provide strong evidence for two phases of accelerated expansion in our Universe. The late-time phase of acceleration, termed ’dark energy’, is consistent with an extremely small positive cosmological constant, while the evidence for a very early phase of acceleration increasingly supports cosmological inflation. Very recently, the BICEP2 experiment reported the detection of B-mode polarization in the CMB. Pending future corroboration, this may correspond to a detection of primordial gravitational waves with a fractional power of about 10% of the CMB temperature fluctuations. In the context of inflation this implies an inflationary energy scale close to the scale of Grand Unification, and a large field excursion of the inflationary scalar field. Hence, the inflationary scalar potential needs symmetries to protect it from dangerous quantum corrections. These features strongly motivate the study of high-scale inflation in string theory as a candidate theory of quantum gravity. We will determine the range of predictions for large-field high-scale inflation in string theory driven by the mechanism of axion monodromy, which was co-discovered by the PI. For this purpose, we will establish a catalog of primary sources for large field ranges from axion monodromy in combination with assistance effects from multiple axion fields. We will analyze the generic effects of the interplay between large-field models of inflation in string theory with its necessary prerequisite, modul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Competitive Auxiliary Power Units for vehicles based on metal supported stack technology' (COMPASS) under Horizon 2020.

assistant: **Objectives**

The COMPASS project is a collaborative effort of AVL, Plansee, Nissan and Research Center Jülich to develop advanced SOFC APU systems for range extender applications in passenger cars. The consortium is perfectly integrated from powder-, cell-, stack-, APU system technology providers to vehicle manufacturer and an academic partner. The project will use innovative metal supports SOFC stack technology, which enables key features like rapid start up and mechanic robustness for this application. Within the project advanced APU systems will be developed with electrical efficiency above 50%, a start up time below 15min and a small packaging size suitable for integration into battery electrical vehicles. Under the lead of NISSAN also a prototype vehicle will be build up, where an APU system will be completely integrated into the electrical powertrain. A major focus of the project is technology validation and systematic durability/reliability development. Therefore in a specific workpackage all validation activities are concentrated. The validation testing includes tests on stack, APU system and vehicle level. The APU system will furthermore undergo automotive testing like vibration, altitude, climate chamber and salt spray. In an additional dedicated workpackage manufacturing cost and business case analyses will be performed. These analyses will help to reduce the technology cost by design-to-cost and design-to-manufacture measures and show the business case of this new powertrain concept compared to other alternative and conventional propulsion concepts. This project is worldwide the first approach to integrate SOFC APU systems into electrical powertrains and will help to significantly improve APU systems also for other applications like heavy duty trucks, marine and leisure/