RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Personalised pharmacometabolomic optimisation of treatment for hypertension' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Hypertension, or high blood pressure (BP), is a serious medical condition, and the single biggest contributor to circulatory diseases which continue to dominate as the leading cause of death and morbidity across the EU. It accounts for almost 10 percent of all healthcare-related costs. Systolic hypertension leads to a broad variety of diseases with an immense impact on both patients and healthcare systems.HYPERMARKER will unleash the potential of pharmacometabolomics to provide a ‘smart’ prescription of antihypertensive therapy. Well-phenotyped cohorts from eleven European countries will provide metabolomic profiles and blood samples for pharmacometabolomic assessments to identify predictors of treatment response in hypertension using advanced AI and deep learning methods. Prediction models for individual treatment responses to antihypertensive medication will be clinically validated and refined through an innovative RCT across 4 sites in Europe. The result is a clinical decision support tool that will give clinicians the ability to make an informed selection of whether the patient they are treating will best respond to the use of angiotensin inhibition, calcium antagonists, beta-blockers, or a range of other existing drugs with evidence-based for BP control.To ensure sustainability, the project will also develop a framework for the uptake of this tool in routine care for patients with hypertension across Europe and beyond. HYPERMARKER will be implemented by a group of world-class scientists and clinicians from a diversity of disciplines who have collaborated multiple times and have a track record of leading key national and EU-funded initiatives to deliver high-impact results.


**Keywords:** Pharmacometabolomics; Optimising treatment; Hypertension; Companion diagnosti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Musical Interaction Relying On Reflexion' in the context of a Seventh Framework call.

assistant: **Objectives**

The MIROR Project deals with the development of an innovative adaptive system for music learning and teaching based on the reflexive interaction paradigm. The platform will be developed in the context of early childhood music education. It will act as an advanced cognitive tutor, designed to promote specific cognitive abilities in the field of music improvisation, both in formal learning contexts (kindergartens, primary schools, music schools) and informal ones (at home, kinder centres, etc.). The reflexive interaction paradigm is based on the idea of letting users manipulate virtual copies of themselves, through specifically designed machine-learning software referred to as interactive reflexive musical systems (IRMS). By definition IRMS are able to learn and configure themselves according to their understanding of learner's behaviour. We propose to extend the IRMS paradigm with the analysis and synthesis of multisensory expressive gesture to increase its  impact on the musical pedagogy of young children, by developing new multimodal interface. The project will be based on a novel spiral design approach involving coupled interactions between the technical partners and the psycho-pedagogical ones. The project will integrate both psychological case-study experiments, aiming to experiment cognitive hypothesis concerning the mirroring behaviour and the learning efficacy of the platform, and validation studies aiming at developing the software in concrete educational settings. The project will contribute to promoting the reflexive interaction paradigm not only in the field of music learning but more generally as a new paradigm for establishing a synergy between learning and cognition in the context of child/machine interaction.The project mostly addresses target c) concerni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NUMERICAL SIMULATION OF DEFORMABLE SOLIDS IN TURBULENT FLOW' (NSDSTF), addressing dissemination and exploitation.

assistant: **Impact**

The numerical simulation of deformable solids has many applications in fluid-solid interaction such as hydroelasticity and aeroelasticity. The greatest application is in medical engineering in which it will be possible to simulate the movement of tube like structures such as the oesophagus, intestines, bile duct, fallopian tube, uterus, ureter and blood vessels etc. However, the numerical simulation of the movement of individual blood cells in either a laminar or turbulent fluid flow is particularly difficult because it not only involves the correct modelling of the fluid flow but also the movement of the cells themselves which, in turn, requires the correct modelling of their dynamics, surface stresses and their surface deformations in response to these stresses. This project is aimed at investigating the deformation, movement and collision of deformable solids in laminar and turbulent flow. In order to do this it will be necessary to couple existing in-house discrete element and computational fluid dynamics codes. The boundaries of the solids will be allowed to deform under the pressures and stresses imposed on them by the surrounding fluid. Such a numerical scheme would also involve taking into account the possible collision of the cells and their ‘shielding’ and imbrication by other cells. The potential benefits of a code that could do this are enormous as it would be possible to investigate the exact cell movement mechanism, and lead to the design of better stents. A further project objective is to carry out simulations of peristaltic pumping by wavelike contractions which are fundamental biomechanical mechanisms for fluid and material transport and are used in the oesophagus, intestine, oviduct and ureter.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'METLINK: Identification of links between cancer cell growth and metabolism genes.' (METLINK) targeting Horizon 2020.

assistant: **Abstract**

Metabolism is crucial for cellular survival. The large amount of evidence covering metabolic entries is mainly about theenzymatic processes and single reactions happening within the metabolic map, but there is poorer understanding of thecellular growth signaling network and regulation around metabolism. With METLINK we aim at identifying new andpreviously undiscovered selective links between metabolic genes and cellular growth pro-survival mechanisms. The hits willbe identified with the use of a pooled libraries of CRISPR/Cas9 lentiviral vectors against metabolic genes and cell cycle/cancer genes. The metabolic library targets will be divided into sub-pools (carbohydrate metabolism: 245; inositol metabolism and lipid metabolism: 571; tricarboxylic acid (TCA) cycle, respiratory chain, integration energy metabolism: 240; nucleotide metabolism, vitamin synthesis and biological oxidations: 361; amino acid metabolism and protein processing: 667; others: 355) and therefore be amenable to medium-throughput screening and selected metabolic processes interrogation. The cancer/cell cycle genes target will be approximately 500 genes. The screening will be initially performed on the human fibroblasts BJ and IMR90, easier to genetically modify, and later validated in other relevant cancer cell line. This will result in the identification of new Achilles’ heels in cancer within metabolism and propose new druggable targets. They will be validated and screened with a library of compounds actually present at SciLifeLab within Karolinska Institute. Lately this proposal will elucidate potential links between oncogenes or cellular growth genes and metabolic genes providing new avenues for treatment within metabolic reactions.


**Keywords:** cell cycle, CRISPR, Cas9, synthetic lethality, m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Learning to Combine Hierarchical Image Modeling with 2-D Segmentation and 3-D Pose Recovery of Visual Objects', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The field of statistical pattern recognition of visual information using digital images is experiencing a boom of scientific discoveries and technological applications. The ultimate goal of this field is to make computers “understand” a scene captured with a digital camera, in the following way: given a still picture, how can a computer automatically identify what is present (image annotation and context identification), and estimate the 3-D pose and segmentation of the visual objects. The solution to this problem involves the reverse engineering process of how an image is formed. This process comprises an analysis that estimates a 3-D model that may have generated the scene, followed by its verification in the image. This problem is essentially ill-posed because several different models (i.e., different interpretations) can lead to similar pictures. Therefore, the computer has to decide on the most likely model (among several ambiguous models) using image features, statistical models of visual objects, and relations between visual objects to constrain the complex search space for scene interpretations. This application introduces a proposal for a novel methodology to solve the problem above based on a principled probabilistic model that combines hierarchical context classification, visual class recognition, 2-D segmentation, and 3-D pose recovery from 2-D images. This project is relevant for the scientific community and for the industry. For the industry, the technologies developed in this project can improve the accuracy of image search and annotation systems, such as Google images, Yahoo images, Theseus, and Quaero. For the scientific community, the 3-D model abstraction will allow for the recognition of new visual classes with consistent shape information and varyin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Evidence-based support for transition to agroecological weed management in diverse farming systems and European regions' in the context of a Horizon Europe call.

assistant: **Objectives**

There is an urgent need to move towards sustainable weed management strategies. Agroecology offers a unique approach & seeks to transform food & agriculture systems, providing long-term solutions. Challenge 1: Agroecological practices are already applied to different degrees. However, wide adoption of agroecological weed management has lagged behind our understanding of its benefits and way to optimally apply it in different cases.Challenge 2: Even with simple agroecological practices, uptake by farmers has been limited. Impediments to employing such practices include inadequate policy instruments, a lack of market mechanisms, and a paucity of social infrastructure with which to influence learning & decision-making by farmers.Challenge 3: Weeds are expected to become more difficult to reliably control with herbicides under increasing CO2 and climate change (CC). Nevertheless, practical implications of climate change for the many non-chemical tactics integral to agroecological weeding have not been thoroughly addressed yet.CONSERWA will address the aforementioned challenges by: a) compiling a portfolio of agroecological farming practices, studying their optimal combinations & transferability, including suitability under CC scenarios, b) supporting the implementation of these combinations and the measurement of their performance & impacts using novel tools, c) supporting knowledge management & communication between stakeholders with the ultimate goal of practical decision-making and impact assessment through an open DSS, d) studying factors influencing farmers’ decision-making in applying agroecological farming, working together with the value chain, such as the food processors & consultancy services. The study will be facilitated by case studies covering all European bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring Thermoelectric and Spintronic properties of Molecular Devices' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The development of wearable and diffuse electronics has prompted a global need for converting heat into electrical power.This could be heat from reactors, the sun, or even the human body. Thermoelectric materials are ideal candidates, since they contain no moving parts, can be fabricated as thin films and are scalable. However, they currently see only niche application, owing to their very low efficiency. Bulk materials offer little room for progress: the ingredients to reach high efficiencies are mutually contradictory in the bulk. In contrast, theory clearly indicates that molecular nano-materials do not suffer from such constraints and may provide a solution. In TherSpinMol I will develop the first molecular thermoelectric devices ever, and, in a groundbreaking effort, I will establish the experimental foundations for molecular spin-caloritronics.To this end I will explore the thermoelectric and Spintronic properties of molecular electronic nanodevices constituted by graphene bulk electrodes with a single molecule sandwiched in between. I will use a novel device architecture consisting of micro-heaters next to the device and different functional contact metals. By this means I get access to the thermoelectric and spin-calorimetric properties of cross-conjugated molecules, fullerenes and single-molecule-magnets with the final goal to explore the Seebeck and spin-Seebeck effect in those systems. Superconducting contacts will be used to measure the absolute spin-polarisation of the tunnel current through single-molecule-magnets. The project has fundamental and applicative significance, aiming at exploring both the physics background of Fano resonances and novel ways to create pure spin-currents and their perspective applicability for the reduction of energy consumption
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Dark Matter Phenomenology in Strong Gravity'.

assistant: **Innovation**

A new era has come in the quest for dark matter, due to the absence of evidence for the most popular candidates, despite the enormous effort that has gone into searching for them. Here, I argue that the advent of precision gravitational wave astronomy offers a new extraordinary opportunity to discover DM in the strong gravity regime, and to uncover its particle properties. In a series of recent breakthrough studies, my team has shown that upcoming gravitational interferometers will be sensitive to the characteristic features in the gravitational waveforms induced by matter, and in particular dark matter, in the extreme environment around black holes, as long as our models are accurate enough. The aim of the De Tenebris project is to formulate clear and accurate predictions of the dark matter phenomenology in strong gravity, to enable the discovery of dark matter with gravitational waves. To achieve this goal, we will build relativistic waveforms of binary black holes in presence of dark matter; determine the merger rate of binary black holes in presence of dark matter; assess the gravitational wave signature of dark matter self-annihilation and self-interaction. Discovering dark matter in the strong gravity limit would be an extraordinary achievement per se, as it would validate a central prediction of Standard Cosmology. But my dream is to identify its nature by studying its signature on the observed gravitational waveforms, and find the path to extending the Standard Model of particle physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Theoretical study of the reactivity in polyatomic systems - the o - 3p - +h2s, o - 1d - +h2s and o - 1d - +ch4 reactions' (1994-1998).

assistant: **Concept**

Research objectives and content The object of the research project is to perform a detailed RBA quantum-mechanical study of the 0(3P)+H2S, O(1D)+H2S and O(1D)+CH4 reactions. The RBA method will be improved to deal with such complex systems. The first step of the project will be the fitting of an analytical potential energy surface for each system using an advantageous model developed during my Ph. D. period. Afterwards, the classical trajectory method will be used to get preliminary results and to refine the PESs. Finally, the RBA method will be applied. The results will be compared with available experimental data. Training content (objective, benefit and expected impact) The theoretical interest of this project is mostly related to the improvement of the RBA method to be used for polyatomic reactions involving electronically excited atoms and long-lived complexes and being characterised by very deep potential wells. Furthermore, the theoretical study of such reactions is a state-of-the-art computational challenge; therefore, last generation supercomputers and modern programming techniques will be used. The practical interest of the project concerns the key role of the 0(3P)+H2S, O(1D)+H2S and O(1D)+CH4 reactions in atmospheric and high-temperature combustion processes. In spite of their interest these reactions have never been studied theoretically so far.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Engineering biological signaling pathways using synthetic cells' in the context of a Horizon Europe call.

assistant: **Objectives**

Facing the challenges of the XXIst century related to climate, energy and health requires the development of new biotechnologies. Synthetic approaches of biology represent an opportunity for applications where living cells are inefficient, inadapted or undesired. Yet, ‘Only cells can make cells’ remains to date an unrefutable fundamental reality and constructing de novo living systems represents the new frontier of biotechnology. The IT industry developed over the years highly complex and integrated microsystems, based on building blocks such as the transistor and fundamental principles of electrodynamics and quantum physics. The analogon for biology must still be unraveled to develop the biotechnologies of the next century. Our aim is to produce life-like systems of synthetic cells in interaction with their environment. We will train Doctoral Candidates to develop a toolbox of experimental building blocks, based upon soft microcompartments, molecular transporters, DNA nanotechnologies, optical technologies and microtechnologies, for the construction and integration of large population of interacting synthetic cells. Because they are built from scratch with a high-level of functional characterization and control, these cells will allow to unravel fundamental principle in life complexity and, at the same time, become integrable building blocks - analogon of the transistors of the IT industry - of a new type of biotechnology. They will pave the way for applications of synthetic cells addressing the pressing needs of the XXIst century, in energy harvesting, biomass and raw matter transformation, bio-remediation or therapeutics. Our network based upon interdisciplinarity in research and innovation, will train the next generation of independent and responsible scientists to