RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'INTEGRATED TOMOGRAPHIC INVERSION IN 3-D USING IRREGULAR GRIDS FOR HYDROCARBONS AND COAL PRODUCTION' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The proposed system is a tool for the integrated processing and interpretation of geophysical data in 3-D. The arrival times of seismic pulses are initially picked from the field records; the travel times are then inverted, updating in sequence the shape and local density of the grid and (if reflected waves are available) also the structure of the reflecting surfaces.Our goal is to demonstrate the use of the 3-D tomography for industrial applications, as reservoir geophysics, seismic exploration and coal mining. We will integrate the already available tomographic software into the seismic package developed and commercialised by Jason Geosystems. In this way, different users will easily apply it at a large scale, interpreting the velocity field in 3-D with other geophysical information, as seismic stratigraphy, acoustic impedance and well logs.A major contribution of the project to the energy saving is the reduction of failure risks in exploration and production of fossil fuels. The payback may be dramatic: the total project cost is only a part of the cost of just one dry well. The new technology should reduce significantly the risks of this occurence.The different partners processed the scheduled data sets for the system demonstration with satisfying results. The tomographic inversion of seimic velocity by irregular grids provided results clearly better than conventional methods. When using the tomographic velocities for the pre-stack depth migration, we obtained images with higher resolution than that one provided by conventional methods. Furthermore, we observed a better match between tomographic and sonic log velocities than when considering stacking velocity spectra plus Dip Move Out. Finally, the system was improved according to the feed-back from the partners.Tomo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'CELLS INTO ORGANS: FUNCTIONAL GENOMICS FOR DEVELOPMENT AND DISEASE OF MESODERMAL ORGAN SYSTEMS'.

assistant: **Innovation**

New approaches to treating disease are set to revolutionise health care. Cancers will increasingly be treated by targeted molecules, not cytotoxic drugs. Manipulating stem cells for cell and tissue replacement therapies holds great promise for treatment of degenerative disease and injury. Both approaches depend critically on detailed knowledge of molecular and cellular events governing normal differentiation of target organs and tissues. This knowledge provides the basis for organ and tissue engineering. Very important life threatening or disabling diseases affect mesodermal organ systems. Heart failure and strokes resulting from atherosclerosis, kidney failure, muscular dystrophy, osteoporosis, tumours and leukaemia are caused either by defects in embryonic development of mesoderm containing organ systems or their function.. These diseases represent the principal obstacles to reaching a healthy old age. This proposal contributes to the knowledge base on which new diagnostic and therapeutic approaches will be based. We will elucidate molecular and cellular processes underlying embryonic specification and differentiation of mesodermal organs. It is clear that many developmental master genes later have key roles in regulating function and that cancers abusively reactivate developmental subroutines. We integrate established methodologies of developmental genetics and experimental embryology with sophisticated modern cell biology and new methodologies of genome scale analysis enabled by genome sequencing. The new technologies will reveal many genes which function in building a specific organ system or in directing a particular aspect of embryogenesis. Analysing these genes, investigating their functions, and placing them in developmental cascades as well as following the ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Learning to communicate in German language through an iconic input interface' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content This proposal aims at developing a second language communication learning software based on an iconic input interface. Its postulates are: first. that learning a language from within, by observing the mechanisms of its linguistic expressions, is a more generic approach than comparing them with those of another language; second, that a learner should not be expected to know a priori the syntactic structures of the language he is learning. Hence the software applies the principle of semantic analysis of icons to tutoring communication. It consists in an interface displaying icons (representing cross-linguistic semantic primitives), with which the user may compose a message; a semantic analysis module. which gives an interpretation to the message with no regard to syntax; a lexical choice interface. allowing the user to refine the meaning he wishes to transmit; and a generation module in German. Such software could prove particularly useful for immigrants or illiterate people. Training content (objective, benefit and expected impact) The project would allow the applicant to acquire experience in managing complex linguistic data, while disseminating novel techniques rooted in the field of cognitive science. Links with industry / industrial relevance (22) The latter techniques were developed by the applicant in an industrial research laboratory. A small company is involved in the project's evaluation and industrialisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Farming as Equals: A Philosophical Investigation of Land Grabbing through the lens of Distributive Justice' in the context of a Horizon Europe call.

assistant: **Objectives**

This research project aims to address the question whether land grabbing engenders a distinct moral concern—one that has not been sufficiently explored. Recent studies in political philosophy that directly address land grabbing take its moral distinctiveness to involve in the way land grabbing undermines territorial rights. A territorial-rights-approach may partially account for paradigmatic instances of land grabbing involving massive dispossession of land from small-scale farmers and of indigenous populations from their ancestral commons. It, however, overlooks increasingly intricate, ‘pin-prick’, forms of land grabbing present in the EU that involve transfer of ownership and control rights over relatively small individual plots of land in such a way that that the aggregate area of land can be quite extensive. In addition, theories about why territories matter for a state do not tell us anything about why land matters for a farmer. I hypothesise that, my preferred conception of distributive justice in farmland—'farming as equals’— offers a more promising moral diagnosis: (1) it maps out an analytical framework within which justice in the distribution of farmland is underwritten by concerns about the equality of farmers; (2) clarifies what is morally distinctive about land grabbing in all its multiple permutations; (3) applies theoretical insights to agricultural and land policies (such as CAP), legal protection of the rights of farmers, and to policy instruments related to environmental justice; and (4) deploys valid normative principles for scrutinising the neoliberal economic model where the concept of ownership (in farmland) is depersonalised and land is transformed from a vital resource for food security to a tradable commodity and an object of speculation. Finall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Partnership for european research in radiation protection and detection of ionising radiation : towards a safer use and improved protection of the environment and human health.' to be submitted under Horizon Europe.

assistant: **Abstract**

The ambition of the PIANOFORTE Partnership is to improve radiological protection of members of the public, patients, workers and environment in all exposure scenarios and provide solutions and recommendations for optimised protection in accordance with the Basic Safety Standards. Research projects focusing on identified research and innovation priorities will be selected through a serie of three competitive open calls.The input to define the research priorities will be based on the priorities defined in the Joint Road Map (JRM) developed during the H2020 CONCERT EJP  but also on the results of ongoing H2020 projects and on the expectations expressed by other actions carried out in other European programmes, in particular the SAMIRA action plan. High priority will be dedicated to medical applications considering that 1) medical exposures are, by far, the largest artificial source of exposure of the European population and 2) the fight against cancer is a top priority of the present European Commission. In order to ensure an appropriate continuity in the research goals and methodologies, in line with the contents of the CONCERT JRM, two other priorities have been identified to further understand and reduce uncertainties associated with health risk estimates for exposure at low doses in order to consolidate regulations and improve practices and to further enhance a science-based European methodology for emergency management and long-term recovery.Once the research priorities defined, the open call system will promote excellence in science and widening participation through a process open to the whole radiation protection community. Beyond the research actions, the selected projects will be able to benefit from the system of sharing and mutualisation of infrastructures that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Restoring balance: how axolotls regenerate otoconia for gravity sensing'.

assistant: **Concept**

Gravity deeply impacts all life on Earth. Organisms sense its directionality and use it for orientation. In tetrapods, the gravitational sense relies on biomineral crystals, known as otoconia, in our inner ear. Their movement is detected by sensory cells, transduced into a neural output, and interpreted by the brain. Deterioration of the otoconia can cause severe balance issues, contributing to diseases collectively referred to as vestibular disorders. Yet, the processes driving both otoconia formation and degradation remain unclear. Limitations in diagnosis of balance disorders in humans stem from the inaccessibility of the inner ear for studying which components are functioning deficiently. In this context there is a need to develop models of vestibular function, disease and restoration. The ultimate goal of OTOREG is to uncover fundamental mechanisms underlying gravity sensation, using the axolotl as a model of regeneration and balance disorders.The morphology of the salamander inner ear is strikingly similar to mammals and my preliminary data indicates that removal of otoconia leads to a balance disorder phenotype. Otoconia then regenerate in the axolotl, restoring correct swimming behaviour and providing a functional readout. This system thus permits a holistic, multilevel approach to understand gravity sensation: I) At the biomaterial level, using structural methods to investigate crystal development and regeneration; II) at the molecular and cellular level, to characterize the genes and cells that drive the formation of the sensory apparatus; and III) at the organismal level, using the behavioural readout to test compounds which might contribute to the degeneration or restoration of otoconia. This detailed understanding of the gravity sensation organ can provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sensing and repair of DNA interstrands cross-links' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

To give further insights in the knowledge of the process of genomic stability maintenance, we will focus our proposal on the understanding of the early events involved in ATR and Fanconi anemia (FANC) pathway activation after DNA interstrands cross-links (IC Ls). We have established that ICLs activate independently ATR protein kinase and FANC corecomplex. Both participate, to the activation of FANCD2 that allow full S-phase checkpoint and DNA repair cohordinating homologous recombination events.We want to determine the precocious events leading to ATR and FANC core complex activation after ICLS. The RAD9, HUS1, RAD1 and RAD17 proteins are key elements of the DNA DAMAGE signalling pathways RAD9, HUS1 and RAD1 form a complex (the 9-1-1 complex) that interacts wit h the RAD17-RFC2-5 complex. The 9-1-1 complex binds to the chromatin in response to DNA damage in a RAD-17-dependent manner. It has been suggested a model in which the RAD17-RFC complex recognizes DNA damage and then loads a 9-1-1 clamp around the DNA. The 9-1-1 tethers signalling and repair molecules to the DNA lesion. Consistently, although RAD17 and ATR associates independently onto chromatin, ATR-dependent RAD 17 phosphorylation requires the 9-1-1 complex, suggesting that 9-1-1 complex recruited by RAD17 enables ATR to recognize its substrates. The role, if any, of RAD17-RFC and 9-1-1 complexes in response to ICLs remains to be determined.It has been recently reported that replication protein A (RPA) is involved in the recruitment of ATR in nuclear foci in response to IR or UV light. Moreover, RPA was found to be essential for ICLs removal, participating to lesion recognition and the subsequent endonucleolytic processing.Our object if is to answer to three questions:1) Are RAD17, the 9-191 complex and RPA inv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeted contrast agents to better detect pancreatic tunor and its zinc content by MRI on mice' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Pancreatic cancer has the lowest survival rate Pancreatic cancer has the lowest survival rate of all cancers in Europe, the median survival time is only a few months due to the lack of test for early diagnosis, and no effective therapies for metastatic forms. Pancreatic Ductal Adenocarcinoma (PDAC), like prostate and hepatocellular cancers present a down regulation of zinc importers and low zinc content. Treatment with clioquinol, a zinc ionophore, to increase the amount of zinc in the tumor has shown to inhibit tumor growth. This project aims at creating new tool to better detect PDAC by Magnetic Resonance Imaging, and the evaluation of di zinc ionophore to elevate the content in zinc in the tumor environment. Using the same modular approach, a normal and a zinc responsive contrast agent targeted to the PDAC will be synthesized by conjugation of a peptidic sequence known to target the tumor bearing a Single Core Multimodal Imaging Platform for quantification, with a peptide functionalized with a normal or zinc responsive contrast agent. After careful characterizations in vitro and ex vivo, they will be used in mice implanted with orthoptic pancreatic tumors. One of the projects developed by the “Metallic complexes for MRI” group, consist designing and using MRI probe for various substrates, including zinc. The group masters all the techniques to characterize the contrast agents, and the experience researcher (ER) will bring the knowledge about zinc biology, and infrared microscopy to quantify the contrast agent in tissues. Benefiting from the competitive interdisciplinary environment of CBM, and within the group, the ER will acquire new technical skills, knowledge and network the frontier between chemistry, biology and MRI imaging, in particular working with animal mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New Method of Magnetic Field Integration and its Smart Grid and Industrial Applications' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Due to massive growth in the use of electric equipment and worldwide increase of the electrical distribution/consumption, the interest in sensors for electrical current measurement, particularly in high voltage levels, has increased significantly over the last decade. Intensive research is carried out in this field. The result is the method based on magneto-optical effect requiring special optical fibers and optical instrumentation. Due to special technologies the sensor is too expensive for most of the industrial applications.Applied Precision is a Slovak innovative company established in 1992 and belongs to the world top three companies in test and calibration systems for electricity meters. The company has developed and patented new breakthrough measuring method based on magnetic field integration with magnetic fiber. The method is not only comparable with the magneto-optical method in high currents applications but significantly more sensitive for low current applications at fractional price level. The most important user benefits are: full integration in smart distributed systems with independent communication, highest accuracy up to 0.1%, simple installation, low operational costs, high interoperability and mechanical flexibility, broad field of applications and very affordable price (less than 20% of  optical solutions).Dramatically lower price of measurement devices, easy and flexible integration in existing or newly designed network measuring and control systems have a unique perspective to bring disruptively new way of their implementation with enormous benefit for monitor the efficiency of energy networks, devices and single participants with positive impact on investments and operational costs and environmental impact.The SmartSense system is targeted at dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'An innovative medical device for early diagnosis based on a disruptive body temperature monitoring and analysis scheme-t-Clinic'.

assistant: **Concept**

In t-Clinic, a novel medical device will be validated as a new additional tool for early detection and prognosis of a number of pathologies: cancer, sepsis, stroke, diabetes, hypertension, infectious diseases, etc., and for different applications: epidemics, critical care, paediatrics, internal medicine, etc., that are based on subtle changes in the body temperature dynamics, not just in its absolute values (discover hidden information, bring to light undetected trends, find new diagnosis correlations).Body temperature quantification systems are currently the primary choice for standard clinical practice. However, due to the low sensitivity and specificity of these methods, a limited field of action, and null dynamics perspective, patients are often referred for secondary procedures, such as blood cultures, for more detailed diagnosis information. These referrals pose a global challenge that postpone treatment, increase the patient risks, and entail higher costs to the healthcare system (materials, labour requirements). There is a worldwide need to reduce the temporal and economic diagnosis costs to enable faster treatment of conditions and more affordable and sustainable healthcare systems by introducing preventive screenings and monitorings for earlier interventions.Innovatec has developed an advanced non-invasive body temperature monitor capable of long-term accurate thermoregulation assessment that can provide a low cost prompt diagnosis tool that will reduce the need for referrals, and will become an effective tool for body temperature dynamics correlation with disorder onset and progression. This is achieved by means of a precise multi-site body temperature monitoring scheme based on a portable wireless device, a set of clinical temperature probes (skin, tympanic,