RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Carboxylic Esters as Bifunctional Reagents in Decarboxylative Cross-Coupling Reactions and Alkene Functionalizations' under Horizon Europe.

assistant: **Concept**

Transition-metal catalyzed cross-coupling reactions have transformed carbon-carbon bond formation in complex organic molecules, revolutionizing fields like pharmaceutical and agrochemical industries, polymers, and natural product synthesis. Despite their vast applications, these reactions heavily rely on toxic organic halides and organometallic reagents that require multiple preparation steps and often lack stability. Carboxylic esters (RCOOE) offer a promising alternative as they are readily available, potentially bio-sourced, and can serve as bifunctional partners in cross-coupling reactions. The ester’s R and E groups can act as nucleophiles and electrophiles upon carbon dioxide extrusion, forming carbon-carbon bonds (R–E) by recombination in an exergonic transformation. However, unlocking the full potential of esters faces a significant kinetic challenge due to the difficult activation of strong C–O bonds. This challenge has limited applications to reactive substrates like allyl esters (E = allyl).The DECAF project seeks to overcome these barriers by developing groundbreaking multi-catalyst cross-coupling reactions using dialkyl carboxylic esters (RCOOE with R, E = alkyl) as versatile and bifunctional reagents under visible-light irradiation. In the first Strand, DECAF will focus on generating reactive intermediates from the cleavage of ester C–O bonds. Their potential as cross-coupling partners will be demonstrated through the example of Heck-type couplings with alkenes. The second Strand will introduce an electron-borrowing strategy to enable the decarboxylative recombination of esters. This unified mechanistic approach will extend the application of carboxylic esters as bifunctional reagents to catalytic alkene transfer dialkylations and, ultimately, decarboxylat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'IMPACT OF DNA REPLICATION ON EPIGENETICS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

During lineage propagation, cells must duplicate their genetic and epigenetic information to maintain cell identity. However, the mechanisms underlying the maintenance of epigenetic information in dividing cells remain largely unknown.In S phase, progression of DNA replication forks provokes a genome-wide disruption of the epigenetic information. While nucleosomes are rapidly reassembled on newly replicated DNA, full restoration of epigenetic information is not completed until after mitosis. This proposal aims to reveal how cells restore epigenetic information after DNA replication. To address this question, I have developed a new technology called Nascent Chromatin Capture (NCC). NCC is a powerful and versatile method that allows purification and analysis over time of proteins associated with replicated DNA. (1) I will identify novel mechanisms in chromatin restoration in mother and daughter cells. To this end I will combine NCC with quantitative mass spectrometry, high-throughput microscopy and screening technologies. Furthermore, I will develop original strategies to directly study the impact of chromatin restoration defects on genome integrity and differentiation potential. (2) It remains unknown whether specific loci as DNA replication origins, have a particular mode of restoration. I propose to develop a new technology, NCC-Ori, to capture chromatin at DNA replication origins. This innovative cutting edge technology will permit to unravel molecular mechanisms that underpin chromatin restoration at these specific sites and uncover chromatin determinants of replication timing and origin activation. (3) Newly identified players that are linked to human diseases will be characterized in order to understand their role in disease etiology and their therapeutic potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Droplet Impingement on Non-flat Surfaces' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The impact of liquid droplets with solids can be realized in numerous physical conditions and technological/industrial applications, for example, spray cooling of hot materials, spray coating, fuel injection in combustion engines, fire suppression, inkjet printing, metallurgy, and electronic circuit cooling. Droplet collision with solid particles also represents a fundamental process in the Fluid Coking processes, which is characterized by the collision between heavy fuel droplets and catalyst/coke particles. The proposed research will explore using computational fluid dynamics (CFD) the detailed physics of liquid droplets impinging on non-flat surfaces; these will include solid particles in midair at conditions relevant to Fluid Coking processes as well as spray cooling applications through droplet impact on micro-porous media. The model to be employed will solve numerically the full Navier-Stokes, energy and transport equations inside and outside the droplet simultaneously with the VOF equation that will be employed for the prediction of droplet shape during impact. In addition, a local vaporisation rate model will be further utilised for the prediction of phase-change without considering empirical correlations for the droplet shape. This will allow predictions at surface temperatures both below and above the Leidenfrost point of vaporisation. Model validation will be performed by utilising experimental data available in the open literature. The developed and validated computational fluid dynamics simulation model will be then utilised for the development of methodologies for design, remedial measures and operation of these devices can then be established for the benefit of the relevant communities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Human Volition, Agency and Responsibility' (HUMVOL).

assistant: **Concept**

At the heart of human nature lies the idea of a free agent, whose conscious thoughts and decisions motivate their voluntary actions, and who is therefore responsible for what they do.  Voluntary actions can be defined as actions that an individual agent generates internally, rather than in response to any environmental event.  However, the concept of voluntary action remains controversial, and lacks a scientific evidence base.  Neuroscience rejects dualistic notions of ‘conscious free will’, and instead views actions as products of mechanistic brain processes, which are often unconscious.  Thus, volition is often eliminated from psychology, or replaced with alternative, more behaviourist formulations such as ‘executive function’, or ‘reward-directed action’.  However, the generative quality of human action, and the strong subjective experience of agency and responsibility for one’s own actions, still require scientific investigation.  Even if we may not have conscious free will as envisaged, cognitive neuroscience has acquired appropriate methods to investigate and measure what we do have, and to explore implications for society.HUMVOL therefore aims to investigate scientifically the neural bases of human volition (Work Package WP1), agency (WP2) and responsibility (WP3).  Subjective aspects are not neglected, because they may offer powerful cues to the mechanisms and functions of voluntary action.  The core methods are behavioural, psychophysical and neural experiments with healthy volunteers.  EEG and fMRI will allow direct measures of brain processes associated with volition, while subliminal priming and non-invasive brain stimulation will allow their direct manipulation.  Mental chronometry and explicit agency judgements allow the impact of these processes on subjec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Critical Phenomena in Random Systems' (CRIPHERASY).

assistant: **Innovation**

This project aims to get a theoretical understanding of the most important large-scale phenomena in classical and quantum disordered systems. Thanks to the renormalization group approach the critical behaviour of pure systems is under very good control; however disordered systems are in many ways remarkably peculiar (think for example to non-perturbative phenomena like Griffiths singularities), often the conventional approach does not work and many crucial issues are still unclear. My work aims to fill this important hole in our understanding of disordered systems. I will concentrate my efforts on some of the most important and studied systems, i.e. spin glasses, random field ferromagnets (that are realized in nature as diluted antiferromagnets in a field), Anderson and Mott localization (with possible experimental applications to Bose-Einstein condensates and to electron glasses), surface growth in random media (KPZ and DLA models). In this project I want to pursue a new approach to these problems. I aim to compute in the most accurate way the properties of these systems using the original Wilson formulation of the renormalization group with a phase space cell analysis; this is equivalent to solving a statistical model on a hierarchical lattice (Dyson-Bleher-Sinai model). This is not an easy job. In the same conceptual frame we plan to use simultaneously very different techniques: probabilistic techniques, perturbative techniques at high orders, expansions around mean field on Bethe lattice and numerical techniques to evaluate the critical behaviour. I believe that even this restricted approach is very ambitious, but that the theoretical progresses that have been done in unveiling important features of disordered systems suggest that it will be possible to obtain solid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Labour Market Change, Unemployment and Citizenship in Europe'.

assistant: **Objectives**

The aim of the conference will be to bring together social scientists who are engaged in research on labour market insecurity and unemployment in Europe. The persistence of high unemployment rates and the prevalence of long-term unemployment in Europe give central importance to the need to improve our knowledge of the sources of labour market insecurity the barriers to exit from unemployment and the consequences of unemployment for the individual and society. The conference will focus upon labour market change and policy in Europe, and how such changes influence labour market insecurity and transitions.The regulations of the welfare regimes of the national states in Europe differ in ways, which may have important consequences for how the individual cope with unemployment. In recent years, a number of researchers have been working on projects than address specific aspects of this issue. The conference, which will give a strong emphasis to comparative research, will seek to bring these together to provide a broader picture of the implications of such regime differences. How welfare regulations influence job incentives and work attitudes, risk of poverty and health among the unemployed, and the consequences for the family and social networks.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00113-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Comparative Analysis and Rationalization of Second-Moment Turbulence Models' under Fourth Framework.

assistant: **Concept**

Today a wealth of microstructure observations have been made in the open ocean, on the shelf and in estuaries. Simultaneously high-resolution numerical experiments on different realistic flow configurations with Direct Numerical Simulations (DNS) of turbulence and Large Eddy Simulation (LES) are increasing in number at a fast rate. More and more turbulence closures are being implemented in numerical circulation models with second-moment closure (SMC) schemes playing the role of workhorses in most cases. Except for a few papers authored by CAlRTUM Partners, most of them still in print, no organized attempt has been made to bring microstructure observations, closure models and direct numerical simulations together. Hence, one would think that significant progress in the representation of small-scale processes in circulation models could be gained from systematic comparisons of the above methods.Furthermore, for modellers there exists an urgent need to compare their results with laboratory experiments, especially for stratified flows, because at present some classical SMC schemes are in clear contradiction to laboratory observations. Consequently, CARTUM sets out to meet the challenge to merge theoretical aspects, new field observations, laboratory measurements, and computer-generated data sets with computational and numerical considerations with the ultimate goal of significantly improving second-moment closure models. CARTUM aims at bringing together the critical mass of unresolved problems, diverse but pertinent datasets, and a host of scientists ranging from world-leading experts in the field of marine turbulence to younger researchers with specific experience.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'CO2 Human Emissions'.

assistant: **Concept**

The CO2 Human Emissions (CHE) project will coordinate efforts towards developing a European monitoring capacity for anthropogenic CO2 emissions. This challenging target is aligned with the European Commission’s stepwise approach for a requirement-driven integration of Earth observations, from remote sensing and in situ, with enhanced modelling capabilities for CO2 fossil fuel emissions, along with other natural and anthropogenic CO2 emissions and transport. The project will pursue a consolidated methodology for integrating the monitoring system components, as well as innovation for estimating fossil fuel CO2 fluxes. These include reconciling bottom-up and top-down constraints and handling systematic errors of satellite sensors. Earth observations from satellites will be combined with in situ CO2 observations and information from co-emitters or isotopes to support the attribution of fossil fuel emissions and uncertainty reduction. Methodological advances will include a representation of anthropogenic CO2 variability in space and time, responding to documented shortcomings and needs, and a carbon cycle data assimilation system extended to enable estimates of emission uncertainties. Strategies to separate anthropogenic CO2 emissions from biogenic fluxes at country to global scales using observations and models will be documented. CHE will support a large community by providing a library of realistic CO2 simulations from global to city scale to examine the capacity for monitoring future fossil fuel emissions and to adequately dimension space mission requirements. Community building will include direct collaboration across 22 European institutions, and communication and liaison with key European and international stakeholders. These coordination efforts will ensure the trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Signals for Inter-Organelle Communication in Abiotic Stress' to be submitted under Horizon Europe.

assistant: **Abstract**

Abiotic stress is a major challenge for plants, especially as extreme conditions like heat and drought are becoming more frequent due to global climate change. Unlike animals, plants cannot move to escape harsh environments and must instead adapt their metabolism, physiology, and growth to survive. These adaptive responses rely on specialized sensors and signaling hubs within the plant, including organelles, which have been identified as key players in stress responses. While much research has focused on how individual organelles respond to stress, there is still a lack of understanding of how these organelles communicate with one another to coordinate stress signals and maintain cellular balance. This project aims to bridge that knowledge gap by exploring the communication between two key organelles, the endoplasmic reticulum (ER) and chloroplasts, and their role in helping plants cope with heat and drought—two of the most significant challenges plants  face. Under stress, organelles like the ER and chloroplasts send retrograde signals to the nucleus and other parts of the cell to trigger adaptive responses. However, the specific mechanisms of this inter-organelle communication remain largely unknown. By combining traditional molecular genetics with advanced transcriptomics, physiological profiling, and AI-assisted data analysis, we aim to identify and characterize novel signals and further study known players that mediate this vital organelle crosstalk. Ultimately, our research could pave the way for developing crops with enhanced resilience to environmental stress, addressing some of agriculture's most urgent challenges in the face of climate change.


**Keywords:** ecophysiology, abiotic stress, plants, global change, signal transduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of a novel family of lim-homeodomain proteins in the development of the mammalian central and peripheral nervous system' (1994-1998).

assistant: **Concept**

The enteric nervous system is the most complex part of the peripheral nervous system, composed of a large number of phenotypically diverse neurons, organised into a complex synaptic network. Despite the detailed morphological and phenotypic characterisation of the enteric neurons, very little is known abeut the molecular-genetic mechanisms underlying their differentiation and diversification. A family of genes that has been established to play a critical role in various differentiation processes is the LIM-homeodomain (Lhx) gene family. Using degenerate oligonucleotide primers and RT-PCR, I have identified two novel members of the Lhx gene family (Lhx-x and Lhx-y) which are expressed in the developing enteric nervous system and the diencephalon of mouse embryos. Here, I propose to: first, generate the necessary reagents and study in detail the pattern of expression of the Lhx-x and Lhx-y genes during mammalian embryogenesis and second, carry out ectopic expression and genetic experiments to determine the role of the Lhx-x and Lhx-y genes in the development of the enteric nervous system and the brain of the mouse.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Complexity and Quantum Invariants of 3-Manifolds and Knots'.

assistant: **Concept**

The complexity of a 3-manifold is a certain integer that rigorously expresses an intuitive estimation of how complicated the manifold is. Being a rather natural and powerful invariant (for instance, only finitely many closed irreducible manifolds can share a given complexity), it plays an important role in dealing with one of the central problems of low-dimensional topology, namely the classification of 3-manifolds. However, its exact position with respect to the rest of 3-dimensional topology, and particularly its connections with other 3-manifold invariants, are not fully understood yet. Only relations with homology and the hyperbolic volume have been explicitly described so far.The aim of the project is to fill this gap (at least to some extent), by establishing connections of complexity with invariants other than homology and the volume, and by exploring several new approaches to complexity. In particular, we expect to discover relations with the theory of quantum invariants, which play an especially important role in the above-mentioned classification task. To meet this goal, we plan to found a certain new combinatorial technique for treating framed links in 3-manifolds. Since surgery on framed links has a crucial importance within the theory of quantum invariants, we believe that this technique will also be a helpful tool for studying these invariants for their own sake.Furthermore, we would like to develop the theory of complexity in several other directions, specifically to analyse its connection with domination between 3-manifolds and to investigate certain notions of complexity for 3-orbifolds and knots. Meeting these aims will use, among other tools, methods relevant to other branches of mathematics, such as geometric group theory and the theory o f accessibi