RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Addressing Unknowns and Unmet Needs of VEXAS Syndrome by Multiomics Clonal Tracking and Targeted Gene Editing' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Hematopoietic stem cells (HSCs) accumulate somatic mutations during aging, which may drive clonal expansion of their progeny. This clonal imbalance promotes cancer and often establish systemic inflammation contributing to frequent diseases of aging. Disentangling and tackling clonal imbalance of hematopoiesis is thus an urgent challenge with substantial medical implications for a progressively aging population. VEXAS syndrome is a novel, adult-onset, devastating disease with growing number of patients. It is caused by the expansion of pro-inflammatory hematopoietic clones acquiring somatic mutations of the UBA1 gene. Its pathophysiology is elusive, and treatments are unsatisfactory leading to dismal prognosis. In this project I will address knowledge gaps and unmet medical needs of VEXAS syndrome, here proposed as paradigmatic example of a hematologic disease of aging caused by clonal expansion. To unveil the uncharted pathogenesis underlying VEXAS clonal expansion and inflammation I will develop and apply to patients samples innovative multiomics technologies simultaneously informing on phenotype and genetic mutations of clones while reconstructing hierarchical relationships and retrospectively tracing expansion dynamics. To validate these findings in stringent settings I will leverage cutting-edge gene editing systems for the generation of VEXAS models by installing in human wild-type HSCs the pathogenic mutations found in patients, and study differentiation, clonal expansion and inflammatory properties of their outgrowth in transplanted immunodeficient mice. Finally I will investigate an autologous HSC gene editing approach in VEXAS models based on the hypothesis that targeted disruption or correction of mutant UBA1 alleles can erase fitness advantage of pathogenic c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Mathematical models of the immunological and clinical epidemiology of plasmodium falciparum malaria'.

assistant: **Concept**

* Construct mathematical models of the immunological and clinical epidemiology of Plasmodium falciparum (P.f.) malaria, and test the model predictions against observations collected independently of this project.* Use the models for helping to: a) calculate the expected impact of interventions; b) improve the design of field intervention trials; c) identify crucial gaps in knowledge that constrain (a) and (b).Expected OutcomeBetter simulation models will help to clarify the following issues:1) Optimal adaptation of control strategies, using currently available methods, to different epidemiological and socio-economic situations, including projections of what could be expected from additional resources;2) Expected benefits from new tools likely to be technically feasible, including different kinds of vaccines;3) Optimal development and evaluation strategy of such new tools.* Review of relevant biological, clinical, and epidemiological knowledge* Specification of observations to be used as modelling targets: a) longitudinal data on the behaviour of P.f. infection and disease in individuals after one or more experimental inoculations; b) longitudinal data on the behaviour of P.f. infection and disease in individuals naturally exposed to repeated inoculation; c) longitudinal data on the transmission of P.f. and the behaviour of P.f. infection and disease in naturally exposed populations.* Formulation (and reformulation) and programming of the models.* Design, performance and evaluation of simulations. The evaluation will consist primarily of the formal comparison of simulations to observations. The comparisons will suggest revisions of the models' assumptions and parameters values, until an acceptable fit is obtained.* Formulation of recommendations The practical implication
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Here be Spiral DRAGNs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Until recently, it was thought that large double-lobed radio sources are always hosted by massive elliptical galaxies in the local Universe and that the merger phenomenon responsible for the elliptical morphology is also responsible for triggering the AGN. Consequently, the existence of spiral galaxies that host double-lobed radio sources (“spiral DRAGNs”) is inconsistent with leading galaxy formation models. However, these systems have been confirmed to exist, calling into question our current understanding of galaxy formation. This project aims to establish the role of these systems in galaxy formation: either reconciling their existence with current models or challenging the idea of the standard feedback model. I propose a multi-pronged approach to this project: First, I will study the parsec-scale environment in the immediate vicinity of the AGN and determine whether properties of the central black hole in these spiral hosts are similar to those of the black holes hosted by elliptical galaxies; Second, I will study the megaparsec-scale environment of spiral DRAGNs to determine whether their environment is responsible for their unique nature. I will achieve the first science goal using Very Long Baseline Interferometry (VLBI) radio observations. I will achieve the second science goal using a combination of archival and new data at multiple wavelengths. Together these two science goals will enable us to definitively determine whether spiral DRAGNs are a result of the intrinsic properties of the black hole, a result of their large-scale environment, or a combination of both these factors. Furthermore, I will exploit my role as lead for the Radio Galaxy Zoo project on spiral DRAGNs to find more of these sources. To-date there have been only four spiral DRAGNs detected.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cad2000' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The topic of this PhD EuroConference is the complex analysis and holomorphic dynamics of one and several complex variables. These are rapidly growing areas which go now through an especially exciting phase, and they are associated to many of the recent most remarkable developments in pure and applied mathematics (recall for instance that some of the last Field Medals have been awarded for significant progress to bring together all the young leading figures in these fields and have them expose and discuss their work, in most cases related to recent advances towards the solutions of the main open problems in their respective areas.Among these topics we find, for example: Julia sets of positive area, local connectivity of the Mandelbrot set, discontinuities on the Hausdorff dimension of Julia sets, holomorphic motions of hyperbolic sets, local behaviour of several complex variables maps around a fixed point, structure of automorphisms of the n-dimensional complex space, etc. All of them will surely be present in the conference age, have already played a significant role in the recent history of these problems. An important objective is also the stimulation of interdisciplinarity. Complex analysis, in several of its various aspects, has been a basic tools in the development of holomorphic dynamics. But, the interaction works in both ways: in the recent years a substantial part of the development of complex analysis has originated in complex dynamics (for instance, quasiconformal mapping in one variable or pluripotential theory in several variables). In this conference, researchers of all these areas will be present and will therefore benefit from each other's knowledge and, probably, different point of view.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flat Bands for Quantum Metrology' under Horizon Europe.

assistant: **Concept**

The ultimate limit on the accuracy of any measurement is set by quantum mechanics, this also means that quantum effects can be used in metrology and sensing to go well beyond any classical approach. For classical systems, statistical error is proportional to 1/sqrt(N) with N the number of measured particles. Measurements in quantum systems can overcome this limit and reach the Heisenberg limit proportional to 1/N. However, quantum standards and sensors are challenging to put in practice and their working conditions are nowadays intrinsically incompatible (e.g. magnetic field and superconductivity). Therefore, limiting their reach in terms of users and their development as accurate and enhanced quantum technologies. The vision we propose in FLATS is to use twisted bilayer graphene as a multiphenomena platform to develop present electrical quantum metrology standards, working under compatible conditions, and to develop the new generation of metrological sensor, going beyond the International System of units (SI). Their common platform will allow their integration as a single multi-use on-chip quantum lab.To achieve this, we will first create a European twistronics plateform for an unprecedented control of the relative angular alignment between graphene/BN layers.  We will develop novel and original quantum electrical standards with twisted heterostructures.  Our on-chip metrological quantum lab also enables the implementation of metrological sensors beyond the SI. This will be the first step towards quantum-enhanced  measurements  for  metrological  applications.


**Keywords:** metrology bilayer graphene flat bands mesoscopic physics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Evaluation of phage therapy for the treatment of Escherichia coli and Pseudomonas aeruginosa burn wound infections (Phase I-II clinical trial)' (PHAGOBURN), addressing dissemination and exploitation.

assistant: **Impact**

Sepsis is the major problem of large burn patients and a predominant cause of death. The burn wound pathology, combined to a global intensive use of antibiotics (ATB), put patients at high risk of suffering from multidrug resistant (MDR) infections, notably carried out by the Gram-negative bacteria species: Pseudomonas aeruginosa or Escherichia coli. But the last Gram- ATB is more than 20 years old and impeded by spread out exponential resistance. New ATB with genuine mode of action to target current resistant types are out of scope. In this context, MDR Gram- infections are becoming orphan pathologies without treatment. Fighting MDR in burn trauma is becoming an urgent medical need through innovation.PHAGOBURN is focused on a highly promising alternative to ATB: phage therapy. Bacteriophages are viruses that specifically infect and kill bacteria during their replicative cycle. The main objective of the project is to assess the safety, effectiveness and pharmacodynamics of two therapeutic phage cocktails to treat either E. coli or P. aeruginosa burn wound infections. To reach that goal, a combined Phase I/II multicentric clinical trial will be carried out in 3 EU countries (France, Belgium, Switzerland), by different hospital burn units. Prior to that, a GMP bioproduction process will be implemented to produce both drug products according to current EMA standards. Meanwhile, the production process and the trial results will provide basis for an optimization of current regulatory guidelines.PHAGOBURN is coordinated by the French Ministry of Defence. The Consortium also includes the following partners: Pherecydes (French SME) and Clean Cells (French SME) for the GMP bioproduction of drug products, CHU Vaudois (CH) burn wards, as well as the Royal Military Academy of Belgi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MAGLEV-DERIVED SYSTEMS FOR RAIL 2' (2021-2027).

assistant: **Innovation**

The MaDe4Rail 2 project aims to advance the development of Maglev-Derived Systems (MDS) and assess their feasibility for integration into the European railway network. Building on the outcomes of the previous MaDe4Rail project, MaDe4Rail 2 will refine MDS configurations and investigate their compatibility with existing infrastructure, focusing on subsystems such as power, propulsion, levitation and guidance. Through a structured methodology, the project will address key Technical Open Points (TOPs) by developing advanced simulations to analyse vehicle performance, electromagnetic compatibility, and interactions with trackside signalling systems, including Eurobalises, odometry, and radio communication. These studies will be complemented by field testing of core MDS components. Since some performance aspects cannot be fully validated on test tracks, dedicated strategies combining on-field testing and high-fidelity simulations will be used to ensure a robust demonstration and optimal integration. In parallel, a risk and safety analysis will be conducted, and regulatory gaps and standardisation needs will be identified, with particular attention to compliance with the Technical Specifications for Interoperability (TSIs). Technical and socio-economic feasibility of deploying MDS on on the Trans-European Transport Network (TEN-T) will be assessed. A concept for a full-scale, fully autonomous MDS demonstrator will be designed, with the architecture developed up to TRL 5. The project will then contribute to a European roadmap for MDS implementation, aligning with the System Pillar and future system requirements. The project’s expected impact includes accelerating the deployment of innovative and sustainable solutions, supporting modal shift, and reinforcing rail as the backbon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Optical 6G Cell Free Networks'.

assistant: **Objectives**

The OPTI-6G project develops a Photonic near IR Cell Free 5G Network, which does not suffer from interference because of the propagation characteristics of EM waves in this part of the spectrum and provides universal broadband coverage within buildings from pervasively located OWC access points.The benefits of applying cell free near IR networks in buildings are (1) multi-connectivity can be configured with cell free network thereby improving link quality and reliability; (2) there is no longer the need for building owners to subdivide their non-public mobile building network into cellular areas; (3) building owners no longer need to request permission from MNOs to use their licensed spectrum since the system operates at the optical unlicensed bands; (4) interference between inside and outside access is managed by an AI Based Distributed Scheduler; (5) position and orientation of end user equipment can be measured very accurately. It provides solutions to two main barriers to develop this challenge: (i) Brings together a select multi-disciplinary team of research institutions and industries in a collaborative project to develop and demonstrate this vision, who otherwise would not have assembled to achieve this goal; (ii) Develops a proof of concept demonstrator in OLEDCOMM and RUNEL; (ii) Performs experiments to measure position and orientation of end user equipment at UVSQ and UBRU.The starting point is (1) state-of-the-art cell free 5G RAN solution and very high accuracy sub cm accuracy localisation measurement system developed by RUNEL; (2) the state of the art VCSEL infrared source and high-speed PIN photodiodes receivers and that supports 1 Gbps data rates up to 5 m over a field of emission of 25° developed by OLEDCOMM.The project brings together these technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Artificial endosymbiosis'.

assistant: **Innovation**

Living organisms have acquired new functionalities by uptake and integration of species to create symbiotic life-forms. This process of endosymbiosis has intrigued scientists over the years, albeit mostly from an evolution biology perspective. With the advance of chemical and synthetic biology, our ability to create molecular-life-like systems has increased tremendously, which enables us to build cell and organelle-like structures. However, these advances have not been taken to a level to study comprehensively if endosymbiosis can be applied to non-living systems or to integrate living with non-living matter. The aim of the research described in the ARTISYM proposal is to establish the field of artificial endosymbiosis. Two lines of research will be followed. First, we will incorporate artificial organelles in living cells to design hybrid cells with acquired functionality. This investigation is scientifically of great interest, as it will show us how to introduce novel compartmentalized pathways into living organisms. It also serves an important societal goal, as with these compartments dysfunctional cellular processes can be corrected. We will follow both a transient and a permanent approach. With the transient route biodegradable nanoreactors are introduced to supply living cells temporarily with novel function. Functionality is permanently introduced using genetic engineering to express protein-based nanoreactors in living cells, or via organelle transplantation of healthy mitochondria in diseased living cells. Secondly I aim to create artificial cells with the ability to perform endosymbiosis; the uptake and presence of artificial organelles in synthetic vesicles allows them to dynamically respond to their environment. Responses that are envisaged are shape changes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Cryptographic reduced instruction set processor smartcard'.

assistant: **Innovation**

1 To provide an OMI macrocell by refining and enhancing the SOSCARD design and functionality on the basis of experience to date and market requirements,.2 To design and build a smartcard IC of minimum silicon area for the highest level of security and card functionality incorporating the CRISP architecture.3 To design & implement state-of-the-art development tools and supporting software.4 To validate security and trial technology within other research projects.The smartcard and electronic tag market is expected to have annual growth of 30% over the next 10 years. This translates to $500 million of semiconductor chip sales in 1999. There is a clear market need for a low cost, multi-application smartcard using public key cryptography. In order to validate the cryptographic and physical security requirements and enable exploitation through manufacturing of product, a fully functional smartcard IC must be designed and built. The OMI project SOSCARD is developing a powerful new cryptographic reduced instruction set processor, CRISP, to meet the exacting requirements in silicon area and cryptographic performance of smartcard ICs and provides an ideal platform for this work.ApproachThis project will bring together the existing SOSCARD consortium (including world-class experts in cryptographic hardware, software & systems and in RISC processor design) and one of Europes leading smartcard IC designers. This strategic and potent collaboration will enable the excellent features of the SOSCARD project to be refined and combined with memory in a secure silicon design in an area suitable for low cost card production. An independent laboratory will carry out a full security analysis of the chip. Feedback from the SOSCARD project will enable a refinement and enhancement of the CRISP d