RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploitation of nutrient efficiency in forest tree breeding' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

With tne increasea demand for fibers in the future and the simultaneous demand for an environmentally friendly forestry, development of forest tree cultivars that do not draw on limited resources becomes urgent. Equally important might be to identify genotypes that benefit from high inputs of nutrients likely to be used in future intensive fiber farming. Nutrient efficiency has hardly at all been considered in tree breeding programmes. There is enough evidence that it might be worthwile to carry out systematic research to quantify the genetic variation in components of nutrient efficiency. Detailed information on these components may allow breeders to create genotypes with combinations of growth components that never have been tested in nature and that may outperform all genotypes that have existed. Owing to the long generation turn-over in most forest trees it is urgent to develop reliable early tests. Use of nutrient efficiency components might be one way to accomplish this. $LForest tree species of major economical interest and representing major areas in Europe (Eucalyptus globulus, Picea abies, Picea sitchensis, Pinus pinaster, Pinus sylvestris) will be studied in NUTRIGEN. In all these species advanced breeding programmes exist, which also means that many field trials exist. NUTRIGEN is based on a close collaboration between experts in genetics, ecophysiology, mycorrhiza research, and tree breeding. Thus, genetic variation in three components of nutrient efficiency as well as their predictive power for future performance will be studied jointly. The components and our definitions of them are:  Nutrient acquisition capacity = the amount of nutrient taken up by a genetic entry under non-optimal conditions in relation to uptake under conditions of free access to nutr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enzymatic synthesis and activation of sialic acid analogs', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The main objective of this research is to investigate the NeuAc system. This would require the parallel subcloning of two plasmid-based E. coli genes for synthesis (N-acetyl neuraminic acid synthase = NeuS; EC 4.1.3.19) and activation (CMP-N-acetyl neuraminic acid synthetase = CMP-NeuS; EC 2.7.7.43) of neuraminic acid analogs into a commercial expression vector under the control of a strong inducible promoter (e.g., pKK223-3; Pharmacia), as well as the overexpression, purification, and characterization of the corresponding enzymes for preparative applications. Since only few ManNAc analogs are commercially available for the synthesis of sialic acid analogs the first step is to synthesize selected ManNAc derivatives or analogs. In this sense, it would be interesting the synthesis of the thio derivative: that can be very useful in the study of the NeuAc system and in the synthesis of 6-thio-N-acetyl-Dneuraminic acid derivatives. Training content (objective, benefit and expected impact) The synthesis of sialic acids analogues presents an important problem in view of the interesting biological properties that can be anticipated. As well as the synthetic and analytical techniques, with which I have become familiarized during my PhD, this work would include basic techniques of gene technology, protein chemistry, and enzyme-catalyzed synthesis of nucleotide-activated sugars and oligosaccharides, allowing me to use a wide range of methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The Multitudes of Mosquito Viruses and Their Impact on Arbovirus Disease Ecology'.

assistant: **Innovation**

The mosquito virome constitutes not only human pathogenic arthropod-borne viruses (arboviruses) but also mosquito-specific viruses, whose host range is restricted to the mosquito. While metagenomics studies have revealed the mosquito virome to be richly diverse and abundant, our knowledge of these viruses is mostly limited to genome sequence information, and we have little insight into their biology and interactions with the mosquito host. Importantly, the cellular and immunological mechanisms by which mosquitoes deal with multitudes of concurrent viral infections remain to be understood. Furthermore, mosquito-specific viruses have been reported to inhibit or enhance co-infecting arboviruses, leading to substantial interest in leveraging these viruses as a tool to influence the transmission of deadly human pathogenic arboviruses, such as dengue virus. Through MULTITUDES, I will take the first steps in exploring the fundamental biology and ecology of mosquito-specific viruses and their virus-host interactions using established techniques from classical medical entomology to omics approaches. My hypothesis-driven aims are to: 1) characterise the biological properties of mosquito-specific viruses; 2) investigate the heritability and fitness cost of mosquito-specific viruses; and 3) examine the metabolic interactions between mosquito-specific viruses, arboviruses, and mosquito hosts. Given that mosquito-specific viruses are an inextricable part of arbovirus disease ecology, the insights revealed during this project will contribute towards a deeper understanding of mosquito-borne disease transmission under the One Health concept. As such, the knowledge generated has the potential to identify opportunities for improved arbovirus transmission risk mapping and for the future de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CCAM-Employment Realization through the Acquisition of Skills (CCAM-ERAS)' (CCAM-ERAS).

assistant: **Innovation**

CCAM-ERAS aims to build towards the future and address the transition to connected, cooperative and automated mobility (CCAM) from a socio-economic perspective. The project will develop the necessary knowledge and prepare for the possibilities that potentially will arise from the deployment of CCAM, and will aim to increase knowledge regarding the necessary skills required for CCAM deployment. CCAM-ERAS will take advantage of the possibilities arising from CCAM deployment, by envisioning a future whereby CCAM can contribute towards a more attractive and inclusive labour market by providing solutions to ensure that the relevant skills are available and are able to be up scaled across the entire CCAM value chain.  Mitigating the resulting effects of introduction of CCAM requires multi-sectoral knowledge and cooperation between what were previously separate sectors (transport, technology, education etc.) CCAM-ERAS will develop new approaches and solutions to anticipate and mitigate the impacts and rebound effects on potential job losses and job relocations due to the deployment of road based CCAM systems and services, as well as boost innovation capabilities through the availability and upscaling of CCAM-specific professional skills. Schemes and actions that can contribute to the specific labour market challenges will be developed, in relation to specific 'real world' use cases.  CCAM-ERAS will also identify innovations and key innovators relating to CCAM deployment, particularly those relevant to the employment, socio-economic and skills effects  Including various stakeholders in the project activities will be crucial in achieving credibility and support for the results of the project. The development of a roadmap to support the socio-economic transition to CCAM will cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Multimedia understanding through semantics, computation and learning'.

assistant: **Objectives**

Due to the convergence of several strands of scientific and technological progress we are witnessing the emergence of unprecedented opportunities for the creation of a knowledge driven society. Indeed, databases are accruing large amounts of complex multimedia documents, networks allow fast and almost ubiquitous access to an abundance of resources and processors have the computational power to perform sophisticated and demanding algorithms.However, progress is hampered by the sheer amount and diversity of the available data. As a consequence, access can only be efficient if based directly on content and semantics, the extraction and indexing of which is only feasible if achieved automatically. MUSCLE aims at creating and supporting a pan-European Network of Excellence to foster close collaboration between research groups in multimedia data mining on the one hand and machine learning on the other in order to make breakthrough progress towards the following objectives.(i) Harnessing the full potential of machine learning and cross-modal interaction for the (semi-)automatic generation of metadata with high semantic content for multimedia documents.(ii) Applying machine learning for the creation of expressive, context-aware, self-learning, and human centred interfaces that will be able to effectively assist users in the exploration of complex and rich multimedia content.(iii) Improving interoperability and exchangeability of heterogeneous and distributed (meta)data try enabling data descriptions of high semantic content (e.g. ontologies, MPEG7 and XML schemata) an conference schemes that can reason about these at the appropriate levels.(iv) Through dissemination, training and industrial liaison, contribute to the distribution and uptake the technology by relevant end-users
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of extracellular matrix as regulator of ageing through mechanosignaling' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

A recent work published by the host laboratory had redefined aging as a mechano-disease. Transcriptional co-factors YAP/TAZ, masters of mechanotransduction, were critical in stromal cells to prevent aging.  Importantly, restoring cell-ECM communication and YAP/TAZ level was sufficient to ""rejuvenate"" old cells.  Consequently, we hypothesize that the culprit of aging should be searched in ECM changes that drive the loss of mechanotransduction in stromal cells.  Using single cell RNA-sequencing data of mouse dermal fibroblasts and mass-spec analyses of the dermis ECM during aging, we will seek for ECM candidates that may be at the root of this process. Then, we will build an Atlas of the mouse skin during aging using spatial transcriptomic and immunolabeling of mechanoresponsive proteins to unveiled new interconnections between the ECM and altered mechanotransduction during aging. As validation, we will use two complementary in vitro approaches. First, old mice fibroblasts will be culture on a young ECM synthetized by engineered young mice fibroblast lacking specific ECM genes, pinpointing to ECM proteins able to rejuvenate old cells. Second, we will generate 3D organotypic skin culture with keratinocytes and engineered dermal fibroblast lacking specific ECM candidate. We will ask whether it affects mechanosignaling and acquisition of aging traits in both dermis and epidermal compartments. Digging into the “mechanics of aging” is crucial because it would add a new paradigm on the causes of cell senescence and aging, define new markers for healthy aging and inform on new therapeutic perspectives to combat aging or some of its associated pathologies.""


**Keywords:** Ageing, mechanobiology, mechanotransduction, extracellular matrix, mechanosensing, YAP, TAZ, single cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Illuminating the role of selfish genetic elements in somatic tissue homeostasis and aging'.

assistant: **Innovation**

Life-long tissue homeostasis requires sustained function of differentiated cell types as well as progenitor cells, which ensure tissue self-renewal. Little is known about the role that non-genic repetitive DNA sequences play in the maintenance of cellular homeostasis in divers somatic tissues in vivo. Transposable elements (TEs) are omnipresent, highly repetitive DNA sequences that mobilize and propagate within host genomes. Though previously thought to be fully repressed in the soma, TEs can be actively transcribed and, at least to some extent, mobile in certain somatic tissues. Indeed, somatic TE activity was proposed to contribute to normal development, aging, and pathologic conditions, such as cancer or neurodegeneration, underscoring the potential bearing that these selfish genetic elements could have in the soma. Nevertheless, the dynamics of activity and tissue-specific regulation of TE sequences are poorly understood, as is the impact of TE activity on different somatic cell-types and tissues. We have recently uncovered that prevalent, tissue-specific TE mobility occurs in the Drosophila intestine and can lead to gene inactivation and tumor formation. Here, using this powerful and genetically amenable in vivo model system, I aim to combine genomic techniques with developmental and cell biology approaches to address the intriguing interplay between TEs and somatic tissue function in vivo. I will ask: 1- How TE activity differs between diverse cell types and how it changes in a tissue under normal or pathological conditions, as well as during aging? 2- What processes control TE activity in somatic cells in vivo?; and 3- What are the direct consequences of TE transcriptional activity and mobility on somatic cell function, and the long-term impacts at a tissue and o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The future of precise personalised robotic physiotherapy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Back pain affects over 200 million people in Europe and is a leading cause of disability and chronic pain. It is estimated that the impact of pain associated to Musculoskeletal Disorders (MSDs) in society costs the EU up to 441 billion Euros per year. To understand patients’ pain, physiotherapists rely on their experience and patient interviews to develop a treatment plan, obtain data regarding patients´ health, pain status and treatment evolution. This can lead to mistreatment decisions, inconsistency through change of physiotherapist and lack of measurable results. Additionally, labour-intensive massages can raise the treatment costs especially for chronic patients. Consequently, there is a need to increase the quality and efficiency of treatments with the possibility to measure results with detail and subsequently decrease patients´ costs and waiting lists to provide fast and reliable therapy. ADAMO robot consists of a robotic arm capable of highly articulated movements to provide precise therapeutic treatment by applying compressed air, which produces the desired effects on the patient’s back. An Artificial Intelligence system monitors its healing evolution in real time to determine the duration of each session and the number of required follow-up sessions. Thereby, after the physiotherapist corroborates the treatment at the first session the robot can reproduce a treatment plan automatically. All data is securely stored in a distributed cloud system allowing full treatment track for patients to receive sessions everywhere in the World. With our solution we will contribute to tackle the EU and global health problem that affects directly the wellbeing of society with personal and with huge economic consequences for our health care system and our companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'SATELLITES IN TELEMATICS'.

assistant: **Innovation**

The main objective of SATEMA is to provide technical and administrative support for the Commission's contribution to the establishment of a Global Navigation Satellite System. The European Space Agency will primarily contribute to solving outstanding technical issues and will provide technical coordination (Japan and USA). Support will be provided to the High Level Group working in this subject. The project will also provide technical advice on the use of space services e.g. telecommunications satellites, within other projects in the Fourth Framework Programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Full spectrum SOLar Direct Air Capture & conversion'.

assistant: **Innovation**

Ethylene is the chemical industry’s primary building block. SolDAC’s ambition is to reinvent the ethylene industry by proving (TRL4) an emerging breakthrough technology for producing technically and economically competitive, socially desirable and climate-neutral (sustainable) ethylene and co-product ethanol (C2 products) from solar energy and air. The project features a photo-electrochemical conversion (PEC) unit, being electrochemistry the only possible route for direct conversion of carbon dioxide into ethylene. The PEC exploits bandwidth-selected light from a solar collector (FSS) that splits the solar spectrum for electricity and heat generation at efficiency higher than standalone PV modules and standalone solar thermal collectors. Heat is used in an innovative direct air capture (DAC) unit at ultralow temperature (~60°C), fostering the eventual circular integration with heat networks. The DAC unit removes carbon dioxide from the air, concentrates it to 95+% and compresses it to feed the PEC stack and a pipeline for carbon dioxide storage. This allows the carbon footprint of the whole sun-to-chemicals process to be offset and enables gain in carbon credits, opening an opportunity to exceed climate-neutrality and produce carbon-negative C2 products. The process is energetically self-sufficient, economically viable and carbon-negative on the condition that each unit (DAC, PEC, FSS) reach new targets in efficiency. That is exactly the high-risk/high return outcome expected in the project. The research is balanced to overcome technical, early-stage social and market barriers by exploiting the expertise of its 8 partners (SMEs in the renewable technology field, leading EU research institutions and one networking NGO). This project performs all the necessary groundwork
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Semiautomatic Methods for the Creation and Maintenance of Links between Scientific Resource Aggregations on the Web' (SCILINK) under Seventh Framework.

assistant: **Objectives**

The Web has revolutionized the way of publishing and distributing scientific results. If, however, we regard current publications on the Web, they still resemble the production process of traditional print publications and usually do not deliver the relevant or even necessary information for the described research context, such as the data sets required for reproducing experiments. The goal of the SciLink project is to reassess the traditional way of publishing scientific results on the Web. We believe that arranging publications as aggregations of Web resources and linking them with resources in a broader network of data-centric, Web-based information sources (e.g., DBpedia) will allow scientists to better share, reuse, and further enhance their scientific assets. The proposed research objectives will build on established standards, most importantly the Open Archives Initiative Object Reuse and Exchange (OAI-ORE) specification. The central contributions of the SciLink project are: (i) a semi-automatic link discovery framework for establishing links from publications to semantically related resources on the Web (e.g., DBpedia resources), (ii) the development of strategies and solutions for maintaining link integrity in an open information space, and (iii) novel Web-based aggregation authoring and presentation solutions. We expect that a variety of disciplines, which are currently adopting the OAI-ORE specification for their scientific publications, will make use of our proposed research results. Furthermore, with our approach we will also bridge the gap between the developments in the OAI-ORE and those in the Linked Data community. The results of SciLink will also have a direct impact on the European Union’s digital library flagship initiative Europeana, where the OAI-O