RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Differential diagnosis of infecious lung diseases' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Infectious pulmonary diseases form a serious threat to human warfare. Pneumonia continues to be a major health problem despite the availability of potent ant microbial drugs. Bacterial pulmonary diseases are often caused by Streptococcus pneumonia, Mycoplasma pneumonia, Chlamydeous pneumonia, Legion Ella pneumophila, Staphylococcus aurous, and Mycobacterium tuberculosis. Compromised-compromised hosts, such as HIV patients, form a special target group. Diagnostic test are available for these pulmonary diseases but there is still an urgent need for more accurate and rapid diagnoses. This project will focus on developing a simplified and user-friendly test combining detection of pathogen components (nucleic acids/proteins) and host components (antibodies) with a high diagnostic reliability. In its final format the test allows differential diagnosis of infectious pulmonary diseases. The new and innovative part of the project is that the resulting differential test format will have an appreciable added reliability, as(I) the combined pathogen and host response test results will increase the sensitivity of the method, and(ii) the combined testing for the major differential diagnostic causes of lung disease will increase the specificity. The principle of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fungal dimorphism and plant infection during Magnaporthe grisea – rice interaction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Magnaporthe grisea has emerged as a model system for the elucidation of mechanisms of fungal pathogenesis in crops. During the leaf infection process, the hyphal tip of a germinated conidium swells to form a melanised penetration structure known as an appressorium. Subsequently, M. grisea penetrates the leaf epidermis and develops a pseudohyphal and filamentous-like growth to colonise the first infected cell. We plan to use a multidisciplinary approach which includes transcriptomics, cell biology, biochemistry and bioinformatics to elucidate the genetic components required for pathogenesis-related development in M. grisea. The programme of work will be achieved through the functional characterisation of M581 mutant defective in bulbous growth on PS-PHIL. Although several mutants defective in IH growth have been identified in our laboratory, M581 constitutes one of the most interesting mutants for functional characterisation for several reasons. First, its hyperbranching phenotype which has, in other pathogenic filamentous fungi, been associated with reduced host virulence. Second, M581 is tagged in the putative transcription factor MgRFEG, which, due to the nature of the screen, suggests that MgRFEG is regulated by the MAPK PMK1 pathway. We plan to investigate the role of this new putative transcriptional regulator by adressing the following questions: i) What is the function of MgRFEG during plant colonisation and when is it required by the fungus to colonise plant cells? ii) Which genes are differentially expressed during the dimorphic transition of M. grisea on PS-PHIL surfaces and which are regulated by MgRFEG? iii) What are the target genes of MgRFEG and what is the sequence identified by MgRFEG in the promoter regions of these genes?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ACCELERATION OF PHOTOCATALYTIC GREEN HYDROGEN PRODUCTION TO MARKET READINESS THROUGH VALUE-ADDED OXIDATION PRODUCTS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

With rising anthropogenic CO2 emissions resulting in climate change, solutions to rapidly bring green hydrogen to market are required. PH2OTOGEN aims to build a scalable photocatalytic flow reactor for green hydrogen production with parallel production of value-added oxidation products, which will contribute to the revenues of the overall system. The PH2OTOGEN consortium will use advanced characterisation techniques to determine promising and novel combinations of semiconducting materials to achieving an average solar-to-hydrogen efficiency of > 5% over 500 hours in a 500 cm2 demonstrator.


**Keywords:** Solar, photocatalytic, green hydrogen, value added oxidation products
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Low climate IMpact scenarios and the Implications of required Tight emission control Strategies' to be submitted under Seventh Framework.

assistant: **Abstract**

Now and in the foreseeable future, action on climate mitigation and adaptation doesn’t seem to be sufficient to manage greenhouse gases and their impact at the scale required to achieve stringent objectives such as those compatible with the 2°C target. This project aims at carrying out a rigorous assessment of what a stringent climate policy entails, and what is needed to overcome major impediments. This information will allow policymakers to better assess the costs and benefits of aggressive climate targets, and on how to make them implementable. Specifically, LIMITS will avail of the best methodological instruments to assess climate policies, whose analysis will interact with policy evaluation. Key global integrated assessment models will run climate mitigation and adaptation scenarios under new conditions and constraints, and the policy implications will be thoroughly evaluated. The needed physical changes in energy infrastructure and land use needed to comply to climate action will be assessed globally and regionally, for many of major world economies. In addition, the co-relationships of climate strategies with other pressing social and environmental issues, such as economic development, energy security and air pollution, will be analysed to identify a set of robust strategies that have the best chances of making stringent climate policy implementable.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Structure determination of the zona pellucida domain by X-ray crystallography'.

assistant: **Concept**

For all sexually reproducing organisms fertilisation is a fundamental step to ensure the continuity of the species. The events that take place during fertilisation are poorly understood at the molecular level, although a number of components that play crucial roles in this process have been identified in mammals. The mammalian oocyte is surrounded by the zona pellucida (ZP), a specialised extra-cellular matrix consisting of filaments of polymerised ZP domain proteins. Some of these ZP domain proteins serve a s species-specific receptors for the initial recognition of sperm. Upon fusion of the gametes, modification of ZP subunits leads to morphological changes of the whole matrix that inactivate its receptor activity as part of the block against the entry of additional sperm.The goal of this project is to determine the first three-dimensional structure of a ZP domain. So far, no structure is available for this conserved protein, which is thought to adopt a unique fold. Solving the structure would be of outmost importance for understanding the molecular mechanism of crucial steps of fertilisation. Since more than one hundred extra-cellular proteins with diverse functions contain ZP domains, a structure would have implications far beyond the field of fertilisation and it would allow detailed interpretation of the effect of the many ZP domain mutations that cause disease in humans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Ab initio nucleaR Reactions in the Discovery perioD of exotic nuclei.'.

assistant: **Concept**

A century after its discovery, the atomic nucleus remains a subtle organization of protons and neutrons interacting through QCD. Its properties are the driving mechanism of cataclysmic events in the cosmos like those leading to the synthesis of medium-to-heavy elements. Unfortunately, precise, fundamental nuclear data, which are essential both to the sustainability of our civilization through technological applications, and to our understanding of the universe, are still a considerable undertaking to measure or to compute. Our objective is to unlock the applicability of ab initio predictions of nuclear collisions, which have been, so far, lagging behind that of static properties of nuclei. To reach this goal we aim:1) To develop perturbation theory to ab initio reaction modeling, and by this means to open up to reacting systems above the p-shell;2) To exploit the aforementioned development in the context of strict effective field theory for nucleons.We expect these achievements to allow us to contribute to the understanding of the detailed balance between nucleons that will be uncovered at the edges of nuclear stability at facilities like Spiral2 in France and FAIR in Germany.The experience researcher (ER) will bring to the host group its know-how in perturbative methods, of which he has been apractitioner in nuclear structure, and, in doing so, he will boost the applicability of the host ab initio reaction tools. In turn, he will benefit from the supervisors expertise in reaction theory and effective field theoretical tools thereby acquiring a strong and valuable portfolio aiming to perform nuclear evaluation of data and predictions for supporting both theoretical and experimental nuclear astrophysics needs. In conclusion, this project is mutually beneficial to the hos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SKin Healthcare by Innovative NanoCAPsuleS' under Horizon 2020.

assistant: **Concept**

SKHINCAPS project will explore an innovative and sustainable in situ self-assembly nanoencapsulation technology to deliver novel products for skin healthcare applications, with increased efficiency and cost benefits, leading to ground-breaking innovations on the actual products.Using this safe, sustainable and easily scalable technology, different actives will be addressed for nanoencapsulation: phase-change materials (PCMs), a cocktail of vitamins and antioxidants, and natural essential oils. The nanocapsules will be engineered to achieve three possible release mechanisms, enhancing actives efficiency.Different demonstrators will be developed with these customised and safe nanocapsules for skin healthcare applications:- First layer garments with no-release nanocapsules loaded with PCMs, to improve thermal management and skin comfort;- Creams with triggered nanocapsules containing the cocktail, to improve the anti-ageing effect on the end-users skin;- Lotions and textiles containing targeted nanocapsules loaded with natural essential oils to prevent or even mitigate bacterial infections on the end-users skin. These demonstrators will be fully tested for their safety and performance assessment to fulfil the present regulation requirements.SKHINCAPS comprises SMEs from different stages of the supply chain, so it will promote stronger collaborations between materials suppliers, manufacturers and end-users. SKHINCAPS is therefore entirely aligned with the European 2020 strategy, contributing to boost competitiveness and support the creation of jobs and new sources of growth. SKHINCAPS is also committed with the flagships initiatives, and with a number of wider H2020 objectives including: control healthcare expenditure, H2020 strategic cosmeceuticals sector and plural H2020
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MID-INFRARED QUANTUM TECHNOLOGY FOR SENSING', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

To increase our ability to sense the changes in the environment around us, we must understand how to control the quantum properties of light and matter at the fundamental limits of their interaction. As such, quantum sensing is poised to bring paradigm-shifting transformations to how precision measurements are performed. Given the central role that MIR spectroscopy plays on many of the pressing issues facing modern society, there is an urgent need for systematic investments into the innovation and development of MIR quantum technologies for sensing applications.   MIRAQLS brings together an interdisciplinary team of Canadian and European researchers, together with industry partners, who share a long-term vision for the development of MIR quantum photonic technologies for sensing applications. Our team combines expertise in quantum photonics, materials science, optoelectronic component development, MIR laser science and spectroscopy, biophotonics, photonic inverse design, quantum optics theory, and quantum information science, and quantum technologies. MIRAQLS aims to tackle some of the biggest challenges that have hampered the development of MIR quantum technologies, while at the same time delivering concept demonstrators, such as quantum-enhanced Fourier-transform infrared spectrometer (q-FTIR), quantum-enhanced optical coherence tomography (q-OCT) and SU(1,1) interferometry. By manipulation of quantum statistics of the input states, e.g. squeezing and entanglement operations, we aim to achieve better sensitivity bounds in comparison to the classical technology, limited to the operation at the standard quantum limit (SQL).    Improvements in MIR sensing will directly translate to increased societal well-being, safety, and prosperity; it becomes indispensable in the con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Evolutionary games and population dynamics: from theory to applications' in the context of a Horizon 2020 call.

assistant: **Objectives**

Evolutionary game theory (EGT) was developed to model biological populations, and the early models had great success in explaining apparently paradoxical biological behaviour. Animal and human populations are complex, however, involving important factors such as social relationships, space and time. Thus whilst EGT is a great tool to conceptualize and understand real-world biological interactions, standard EGT is often too simplistic and therefore insufficient to describe the interactions at hand with a sufficient level of realism.There has thus been a lot of work in developing more realistic models of populations, including by participants in this project, and this is a rapidly growing area. There is a great shortage of, and need for, highly trained and versatile researchers comfortable with the mixture of mathematical modeling, biological knowledge and expertise in computing and the analysis of data. It is rare for undergraduates to be taught all of these skills, and so a significant training focus is needed at PhD level. The development of a strong group of such researchers is at the centre of this proposal, and we have developed a training plan to give them the required expertise in the relevant areas, and their combination.We will pursue 4 research themes, 2 developing methodology and 2 focused on applications. The first concerns the modelling of structured populations, incorporating more realistic spatial and social interactions. The second considers important out of equilibrium dynamical concepts, often neglected in favour of equilibria. The third focuses on the mathematical modelling of cancer and its treatment. Here the two above concepts are especially important. The fourth considers ecological and epidemiological modelling where the focus is on structural com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NAno engineered Titania thin films for advanced Materials Applications' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

TTitania thin films, suitably doped and/or endowed with novel nano-scale architectures, are very promising materials for industrial and commercial applications because they may be induced to exhibit a variety of radical new properties.A major impediment t o progress is lack of understanding of the relationship between the structure, composition and electronic properties of these systems and the functionalities that they give rise to. A second major obstacle to industrialization is the absence of synthetic methodologies that are reliable, well controlled and amenable to scale up at economical cost.This project is aimed at tackling both the above issues directly. A very wide range of methods ranging from sophisticated ultrahigh vacuum techniques, to electrochemical methods to novel organometallic chemical routes will be used to produce a variety of titania thin film structures, doped, structured, or otherwise modified to yield the desired functional materials. The common features are that the thin films should be capable of photo-activation by visible light and that the method of fabrication is compatible with industrial production.The new multifunctional properties sought include photocatalytic oxidation or reduction activity, photoelectrochemical behaviour, photoconductivity, photochromism, photomagnetic switching, sensing behaviour, photovoltaic response and controlled and switchable" wetting behaviour. Exploitation of these properties is of strategic importance to EU companies in the fields of health and environment protection, advanced materials, sustainable energy production and national and personal security.Provision of new knowledge and expertise in the area of nano-engineered multifunctional titania thin films will open important new market opportunities for Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A First-in-Class MCL-1 degrader to promote apoptosis in therapy-resistant liquid and solid tumours' (CT-03) targeting Horizon Europe.

assistant: **Abstract**

Captor Therapeutics is a biopharmaceutical company pioneering the development of therapeutics for unmet medical needs using Targeted Protein Degradation. We focus on high-value drug targets that are “undruggable” by conventional approaches. One such target is MCL-1, a protein preventing programmed cell-death. MCL-1 is implicated in resistance to cancer treatments. Due to its broad applications, developing a safe therapy that could hamper MCL-1's effect in cancer cells, would be a gamechanger for oncology. Unfortunately, MCL-1 inhibitors give rise to cardiotoxicity, which has led to the termination of several clinical trials. Our unique TPD technology platform allows us to apply a radically different approach. We have developed a small molecule able to tag MCL-1 for degradation using the cellular waste protein disposal system. CT-03, positioned to become a First-in-Class MCL-1 degrader, has shown potent degradation, with no signs of cardiotoxicity in Cynomolgus monkeys, the closest translational bridge to humans. Our first indication – AML (Acute Myeloid Leukaemia) – has a market size of €3.6bn. Currently, Venclexta is commonly used in AML patients unable to undergo ablative chemotherapy or hematopoietic stem cell transplantation. Unfortunately, nearly all AML patients eventually acquire resistance to Venclexta, which leaves them with no further treatment options. By degrading MCL-1, CT-03 will make resistant cells susceptible to conventional therapies again.The project’s goal is to demonstrate safety and lack of cardiotoxicity in humans. Successful results from a Phase Ia/Ib trial on Venclexta-resistant AML patients will constitute a crucial inflection point for securing a lucrative out-licensing deal with a large pharmaceutical company. Our future partner will take CT-