RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'VALIDATION OF A NEW OBJECTIVE DC DEPTH OF ANAESTHESIA MONITOR'.

assistant: **Innovation**

Medical anaesthetic practice has not been standardised between member states of the EU. A new method for determining the depth of anaesthesia (FATHOM) has been developed. FATHOM must be tested and evaluated at several sites within the EU, in order to prove its efficacy with the wide range of anaesthetic agents and adjuncts in routine use. FATHOM also needs to be evaluated as a veterinary anaesthetic monitor.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Protein-engineering based approach to detect oxidative stress-induced changes in the neuronal proteome'.

assistant: **Objectives**

Neurodegenerative disorders are characterised by the progressive deterioration and loss of certain neuronal populations. Distinct clinical features are associated with different diseases, but common fundamental processes have been identified. One example of this is injury via oxidative stress. The production of oxidative species is linked to mitochondrial dysfunction and inflammation, which have been demonstrated to occur early in these disorders. Identifying the proteins that are involved in the response to these species is of critical importance to understanding these diseases. This will provide opportunities to identify novel biomarkers and develop treatments that are effective at these early stages. The use of genetic code expansion to functionalise proteins with clickable amino acids is an emerging protein engineering technology with many potential applications in neurobiology. Recently, it has been demonstrated that any of the 20 natural amino acids can be replaced with a non-canonical amino acid (ncAA) on a proteome-wide scale. However, the application of this technology in complex cells, such as neurons, is still in its infancy. I aim to establish a novel proteome-wide ncAA incorporation methodology to monitor changes in the neuronal proteome in response to oxidative injury. This will be achieved using ncAAs that have been optimised for an inverse-electron-demand Diels-Alder click reaction, which is highly biorthogonal and has extremely rapid kinetics. Adding a clickable biotin handle will facilitate protein enrichment in a highly time-resolved manner. Subsequent proteomic analysis will be applied to identify changes within the whole proteome or subsets of the proteome. Monitoring changes in protein expression in this way will provide valuable information about
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Transients in the Hellenic and Antilles Locii of Earthquakes of European Subductions Water Activity Structure and Seismic Risk Illuminated by Geophysical High Technology'.

assistant: **Innovation**

The occurrence only few months ago of the catastrophic Sumatra M9 earthquake was unexpected; hence Thematic Priorities of FP6 could not have included study of hazard of that type, which this occurrence now proved possible against previous state-of-the-art wisdom. This project presents a scientific measurement approach for the detection of new types of seismic signals, as well as deep structural images that are relevant to the problem, being possible heralds of mega-thrust earthquakes. This will be applied in the two European subduction zones, the Western Hellenic and Lesser Antilles Arc, that may be prone for M>8 earthquakes as they share characters of the Sumatra-Andaman case. These water-related phenomena, deep seismic tremor and silent earthquake, we re recently discovered in Japan and NW US subduction zones, where advanced technologies and methods have been applied.They were reported to have their source region close to the interplate subduction boundary, the mega-thrust fault plane, where possible water content has been revealed by deep structural seismic images. Importantly, these transient signals, are observed in advance of the major M>8 earthquakes expected there. They might in case be considered as possible silent heralds of megathrust earthquakes and monitored. Our project is to apply to these two European subduction areas advanced studies of activity and structure, with novel High-Tech observation means.Among them: Broad-Band Ocean Bottom Seismometers just developed that may detect these new transient signals, an opportunity of seismic reflection imaging with the French academic seismic ship for the Antilles, novelty of a joint integrated approach possible by merging forces at European scale. This scientific measurement approach may open the way to monitorin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Food systems transformation towards healthy and sustainable dietary behaviour' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The EU food system is under considerable pressure for change due to its negative climate, environmental and health impacts. Food system transition will require changing dietary habits of millions of Europeans. PLAN’EAT aims at advancing the scientific basis on factors influencing dietary behaviour and the health, environmental and socio-economic impacts of dietary patterns and deliver solutions for transition through a transdisciplinary and multi-level approach.PLAN’EAT will co-create data and interventions in pan-EU network of 9 Living Labs and a Policy Lab. These living labs will focus on a broad range of population groups, varying according to age, culture, health and socio-economic status. PLAN’EAT entails four steps that feed into each other: (1) Dietary patterns of 9 different target groups from 9 regions will be mapped together with their food environments (2) Factors and drivers influencing dietary behaviour at macro- (food system), meso- (food environment) and micro- (individual) levels will be deeply investigated. (3) A True Cost Accounting database and methodology will be developed and applied, for the first time, on dietary patterns, providing integrated insights into the diverse impacts of current and future diets, including possible synergies and trade-offs. (4) A solution package will be co-developed with food chain actors, consumers and policymakers, incl.: i) a Food System Dashboard, setting out context-specific food policy recommendations; ii) interventions targeting Farm to Fork actors, for farmers, food industries, retailers and food services to create suitable food environments; iii) advisory tools to empower consumers; and iv) improved dietary advice and communication strategies to target populations at large.PLAN’EAT will allow for realizing a tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'OpenAIRE - CONNECTing scientific results in support of Open Science' (OpenAIRE-Connect).

assistant: **Innovation**

Open Science is around the corner. Scientists and organizations see it as a way to speed up, improve quality and reward, while policy makers see it as a means to optimize cost of science and leverage innovation.  Open Science is an emerging vision, a way of thinking, whose challenges always gaze beyond its actual achievements.  De facto, today’s scientific communication ecosystem lacks tools and practices to allow researchers to fully embrace Open Science. OpenAIRE-Connect aims to provide technological and social bridges, and deliver services enabling uniform exchange of research artefacts (literature, data, and methods), with semantic links between them, across research communities and content providers in scientific communication. It will introduce and implement the concept of Open Science as a Service (OSaaS) on top of the existing OpenAIRE infrastructure, delivering out-of-the-box, on-demand deployable tools. OpenAIRE-Connect will adopt an end-user driven approach (via the involvement of 5 prominent research communities), and enrich the portfolio of OpenAIRE infrastructure production services with a Research Community Dashboard Service and a Catch-All Notification Broker Service. The first will offer publishing, interlinking, packaging functionalities to enable them to share and re-use their research artifacts (introducing “methods, e.g. data,software, protocols). This effort, supported by the harvesting and mining “intelligence” of the OpenAIRE infrastructure, will provide communities with the content and tools they need to effectively evaluate and reproduce science. OpenAIRE-Connect will combine dissemination and training with OpenAIRE’s powerful NOAD network engaging  research communities and content providers in adopting such services. These combined actions wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A Genetic View into Past Sea Ice Variability in the Arctic'.

assistant: **Objectives**

Arctic sea ice decline is the exponent of the rapidly transforming Arctic climate. The ensuing local and global implications can be understood by studying past climate transitions, yet few methods are available to examine past Arctic sea ice cover, severely restricting our understanding of sea ice in the climate system. The decline in Arctic sea ice cover is a ‘canary in the coalmine’ for the state of our climate, and if greenhouse gas emissions remain unchecked, summer sea ice loss may pass a critical threshold that could drastically transform the Arctic. Because historical observations are limited, it is crucial to have reliable proxies for assessing natural sea ice variability, its stability and sensitivity to climate forcing on different time scales. Current proxies address aspects of sea ice variability, but are limited due to a selective fossil record, preservation effects, regional applicability, or being semi-quantitative. With such restraints on our knowledge about natural variations and drivers, major uncertainties about the future remain.I propose to develop and apply a novel sea ice proxy that exploits genetic information stored in marine sediments, sedimentary ancient DNA (sedaDNA). This innovation uses the genetic signature of phytoplankton communities from surface waters and sea ice as it gets stored in sediments. This wealth of information has not been explored before for reconstructing sea ice conditions. Preliminary results from my cross-disciplinary team indicate that our unconventional approach can provide a detailed, qualitative account of past sea ice ecosystems and quantitative estimates of sea ice parameters. I will address fundamental questions about past Arctic sea ice variability on different timescales, information essential to provide a fram
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel use of exon skipping technology to study structure-function relationship of dystrophin' (2014-2020).

assistant: **Innovation**

Duchenne muscular dystrophy (DMD) stems from loss of dystrophin in skeletal and cardiac muscles, which leads to loss of ambulation and cardio-respiratory failure. The most promising treatment that could be applicable to 83% of DMD patients is exon skipping, a technology where the EU is a world leader. Antisense oligonucleotide mediated exon skipping targets DMD pre-mRNA to induce skipping of specific exons and restore the open reading frame. This allows expression of shorter dystrophin proteins that lack domains encoded by the skipped exon(s). A crucial question is how to predict which short dystrophins will be stable and functional. This knowledge is fundamental to select DMD patients that would most benefit from this treatment and identify exons worth targeting via exon skipping. The goal of this proposal is to develop a new use of exon skipping technology to rapidly generate mouse models to screen short dystrophins for in vivo stability and functionality in both skeletal and cardiac muscles. This is made possible by a new exon skipping chemistry developed in the UK with unparalleled skipping efficiency in vivo and capable of targeting the heart. I will use this technology to create mouse models for two short dystrophins generated in DMD patients undergoing exon 51 skipping in the current UK clinical trial. I will then biochemically assess their stability and functionality in limb, cardiac and respiratory muscles. Parallel histological studies will assess the presence of muscle pathology with a focus on heart and diaphragm that cannot be sampled in DMD patients. This project will serve as a trampoline for future studies to identify dystrophin exons that when skipped will produce functional proteins with clinical benefits. In addition, this research will generate new f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Value-of-Information Driven Communication for Connected and Automated Transportation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

By fusing the sensing information provided by the automated vehicles (AVs), an accurate and real-time representation of the highly dynamic traffic environment can be formed and disseminated to all traffic participants, to enable a variety of safety and efficiency improving applications and push the transition towards connected and automated transportation. A powerful wireless network plays a key role in this vision. As the number of AVs increases, however, the huge data volume will easily exceed the capacity of the wireless network. Owing to the application-oriented nature of vehicular communication, a paradigm shift towards the value-of-information (VoI) driven design is crucial to avoid wasting network resources and degrading traffic safety and efficiency. Nevertheless, no simple mathematical model and existing theory can be applied to assess VoI exactly. The main goal of the VoiiComm project is to establish a theoretical framework and practical methods for evaluating and modeling VoI statistically, by exploiting the intrinsic relationships between traffic flow, density, and speed, to enable the systematic design of efficient communication protocols. The specific research objectives are (1) Design metrics that capture the space-time statistical properties of VoI; (2) Analytical and empirical modeling of spatio-temporal VoI metrics; (3) Strategy development for efficient sampling and transmission scheduling. By accomplishing these objectives, data congestion and resource waste can be avoided, and the potential benefits of AVs can be maximized as their number gets large. VoiiComm will initiate a fresh new interdisciplinary research area and advance the transformation to sustainable and automated transportation and society. In parallel, it will allow the ER to achieve se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'PROCESSING COMPLEX MATRICES: DESCRIPTION, REACTION-SEPARATION, MODELLING'.

assistant: **Concept**

The DREAM project focuses on the transformation of complex matrices for the chemical industry of the future.  It will focus on Kraft black liquor as a case study. It proposes to design new intensified processes coupling reaction and separation in continuous mode to fractionate a complex matrix: deep-eutectic solvent (DES)-assisted extraction of lignin coupled with depolymerisation, CO2-assisted lignin segregation coupled with pyrolysis, and membrane filtration coupled with oxidative depolymerisation. each fraction will then be valorised  into products of interest through reactive distillation or catalytic upgrading. These processes will be monitored by original descriptors designed using data from on-line analysis. The modelling of each reaction and separation step will be carried out based on these descriptors, to give modules that will be assembled in a global simulation of the process. The interdisciplinary approach combining biomass chemistry, catalysis and chemical engineering will be enhanced through educational methods to overcome epistemological, cognitive and communication barriers between disciplines.The DREAM project represents a radically new approach for studying complex matrices, combining cutting-edge technical expertise with social and philosophical expertise to address challenges of the interdisciplinary research process. By developing new descriptors, models, and integration strategies, it aims to establish a feedstock-product relationship and design new, more efficient, and greener processes, as well as new interdisciplinary methodologies.


**Keywords:** process intensification,  catalytic process,  kraft blac liquor,  lignin,  kinetic modelling & process simulation,  interdisciplinarity research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The Middle Class, Civil Rights and Popular Protest in Urban China'.

assistant: **Objectives**

Since the Tiananmen crackdown in 1989, political reform in China has been put on ice. The one-party state focused instead on turning China into an economic powerhouse that is on track to overtake Japan this year as the world’s largest economy after the US. For the EU, China is now its second most important trading partner. The world has become increasingly dependent on China for its economic growth. But for how long can China continue to enjoy the political stability that has underpinned its economic success and now underwrites global prosperity? Against a background of rising unemployment, a widening gap between rich and poor and rising expectations among its growing middle class, can the authoritarian regime continue to ignore popular demands for greater participation in politics? The Communist Party is facing more and more challenges from an increasing number of popular protests and demonstrations that have spawned new social movements to fight for civil rights. Surprisingly, it is homeowners’ rights groups in the cities that are in the vanguard of this new wave of protests. This project will create an alliance between one of Europe’s top centres for research on China and the prestigious politics department at Renmin university to analyse how homeowners’ rights movements are growing in China’s constrained political context. This alliance is part of a plan build the China Policy Institute at Nottingham into Europe’s leading centre for the study of democratization in China. The project will evaluate how homeowners’ groups have become the unlikely successors of the democracy movement of the 1980s. The findings will enable Europeans to assess the prospects for peaceful democratic change in China, or whether to prepare for the unthinkable consequences of widespread disrup