RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Interplay of plant one-carbon metabolism and redox homeostasis in the context of dynamic DNA methylation (DYNAMET)' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

DNA methylation patterns in natural population are influenced by environmental factors and may be involved in selection of complex traits. Accordingly, there is growing interest to exploit epigenetic variation for crop improvement, a goal of utmost social importance considering the rapidly expanding world population and agricultural challenges from climate change. To better assess the use of epigenetic variation for crop improvement, it is crucial to know more about the dynamics of DNA methylation and the involved mechanisms.DNA methylation is stably maintained during DNA replication to faithfully silence transposable elements and thereby ensure genome integrity. However, recent studies indicate that DNA methylation changes in plants that have been caused by environmental factors, including pathogens, heat, and drought may contribute to resistance against recurring stress. The aim of this proposal is to further elucidate the regulatory mechanisms of dynamic DNA methylation and their effects on plant fitness under environmental stress.We will address this aim by studying the interaction of one-carbon (C1) metabolism, redox homeostasis, and epigenetic regulation. C1 metabolism provides the methyl donor S-adenosylmethionine required for DNA methylation. Accordingly, perturbations in C1 metabolism can drastically affect genome-wide DNA methylation patterns and transcriptional gene silencing. C1 metabolism is tightly connected to redox homeostasis and key enzymes in C1 metabolism are regulated by redox-dependent post-translational modifications. Notably, redox changes are hallmarks of stress responses. Therefore, our objective is to investigate how stress-induced redox changes are linked to alterations in C1 metabolism and epigenetic regulation in the model plant Arabidopsis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design of innovative composite hybrid joints with electromagnetic compatibility' in the context of a Horizon 2020 call.

assistant: **Objectives**

D-JOINTS will explore new innovative composite-metal joints with enhanced lightning strike protection. The design of these joints will be achieved through a dedicated sizing tool. Key design parameters will be identified and coded in the tool. A material properties database will provide the needed material information for the design of each joint. Finally, the new joints will be integrated in a composite nose part. The manufactured demonstrators will be tested for lightning strike protection.The project objectives are:•Model the mechanical and electrical performance of reference joints•Improve the reference joints electromagnetic performance•Develop a sizing tool for dissimilar joints•Manufacture and test the CNP with the new dissimilar joints integrated in the structure


**Keywords:** Dissimilar joints, composites joints, lightning strike protection, sizing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Crypto module with USB interface'.

assistant: **Objectives**

The goal of the USB-Crypt project is to develop and integrate a powerful, but easily portable crypto module with an USB interface as a secure single chip IC. This IC module will contain all of the standard crypto algorithms like AES, DES, Hashing, RSA and ECC. It can then be mounted into an USB dongle like housing for universal use with an I&C equipment fitted out with an USB interface. Specific firmware in the controller part of the module will provide the elementary crypto functions and also low level operating system routines. A generic API will offer easy interfacing to host systems. The practical usability together with the system features will be tested by different security applications like: e-commerce, network security, data encryption and digital security. The overall security quality will be analysed and certified by a Common Criteria evaluation.Objectives:For realising high security electronic commerce and other information and communication security applications a high level security module is necessary: This should be inexpensive, fast and flexible enough to plug it in every critical IT equipment and protected against manipulations.The objective of this proposal is to develop and test with some applications:A hardware security module as a single chip integrated circuit (IC) with all necessary cryptographic functions (symmetrical, asymmetrical and hash algorithms), secure internal memory parts for storing keys and variables and an in module control processor for trusted control of the security functions.An USB-interface to the applications world allows the use with every modern I&C equipment like PC's and other communication or data processing equipment. The implicit crypto control firmware and the host API supports the necessary crypto primitives and the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Entropic rejuvenation of thin glass products by liquid metal immersion' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Mechanical performance and consumer product safety have been major drivers for glass research and innovation. Strengthened glass products are omnipresent in daily life, from rooftop windows and automotive windshields to solar modules, partition walls and covers for handheld electronic devices. However, thermal strengthening as today’s most widespread method for enhancing the strength and reliability of glasses has reached maturity, leaving fundamental restrictions in terms of applicable glass thickness and type. These limitations do not only prevent the further development of sustainable and efficient lightweight glass structures, but also exclude the process from many of the most prolific specialty glass applications. The present proposal targets market readiness and commercialisation of a novel post-processing method for thin-walled glass products which overcomes the limitations of thermal strengthening by achieving a tenfold decrease in accessible glass thickness and/or coefficient of thermal expansion. By this, we will break ground for applying an otherwise intriguingly efficient technology to thin-walled glass products and glass compositions which were previously outside of the process’s capabilities. This will not only enable significant reductions of embodied energy, CO2 and product weight, but also lead to new opportunities in the strengthening of non-sheet glass products, e.g., fibres, rods and tubes on fields such as pharmaceutical packaging, injectors, functional lighting and illumination, and specialty glass substrates.


**Keywords:** glass,  post-treatment,  post-processing,  processing,  mechanical properties,  thermal processing,  strength of materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Phosphate homeostasis and energy metabolism in Dictyostelium discoideum' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Adenosine triphosphate (ATP) is the universal biological energy currency. Its cellular concentration is tightly regulated and depends on rates of glycolysis, oxidative phosphorylation, and obviously on phosphate availability. How is phosphate concentration regulated as a function of the cell’s demands? Inositol pyrophosphates, described as metabolic messengers, are excellent candidates to orchestrate phosphate homeostasis and energy metabolism. The research programme proposed here aims to elucidate the relationships between phosphate homeostasis, energy metabolism, and inositol pyrophosphates using the amoeba Dictyostelium discoideum as a model system. This organism has high levels of inositol pyrophosphates and inorganic polyphosphate (polyP) and, surprisingly, a comparatively low level of ATP, suggesting that inositol pyrophosphates may serve as a phosphate reservoir for ATP production. I will use a combination of metabolomics analysis, steady-state and dynamic flux analysis of ATP, polyP, Pi and inositol pyrophosphate levels, and a functional analysis of mitochondria to evaluate the impact of polyP and inositol pyrophosphates on the metabolic/energetic state of this organism. I will investigate the function of polyP, which is induced during development, to understand how and why phosphate homeostasis is so dramatically modified during this process. This will be the first comprehensive analysis of the relationships between phosphate homeostasis and energy metabolism in eukaryotes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of Triptycene-Based New Hypervalent Iodine Reagents for Selective Organic Synthesis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The challenge of achieving high selectivities (chemo/regio/stereoselectivity) in organic transformations is still very high. Selectivities are achieved through either covalent interactions involving metals or non-covalent interactions such as hydrogen bonding, halogen bonding or ion pairing involving organocatalysts or enzyme catalysts. Triptycenes are highly promising structures due to their rigidity, internal free volume, electron rich cavities, three aromatic rings opened for π-stacking interactions and the possibility of atropisomerism. We want to exploit their potential of non-covalent interactions in chemo-, regio- and stereoselective reactions by using triptycene scaffolds for the synthesis of iodine-based reagents. The proposed research will focus in utilization of internal free volume for selectivity in reactions to explore selectivity through π-interaction. This process will open up new directions by focusing on the following objectives: (a) synthesis of different iodotriptycenes; (b) oxidation of iodotriptycene to iodine(III) derivatives including polymer-based reagents; (c) development of chiral triptycene-based iodine(III) derivatives; (d) application of the methodology in the flow synthesis of target molecules and (e) training through research and career development of incoming post-doctoral fellow. The proposed methodology has the capacity to make a sound impact on the scientific community, and to change existing protocols in industry. The MSC Fellowship will provide the post-doctoral fellow to strengthen scientific knowledge and enrich skills, innovative ideas, managing skills and to establish himself as an international scientist.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Novel heart regeneration strategies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Heart disease and particularly myocardial infarction, i.e. heart attack, is the leading cause of death in the Western world today. The diminished regenerative potential of the heart begins shortly after birth, when most CardioMyocytes (CMs) cease to proliferate and make a transition from hyperplastic to hypertrophic growth. The Tzahor lab has been intensively exploring novel molecules, compounds as well as the molecular mechanisms that facilitate CM cell division in the adult heart of mammals as a strategy for eliciting heart regeneration. These efforts, had led to the identification of novel compounds which significantly increased the proliferation of adult CMs. Drawing upon these findings, the aim of the aNtHESIS project is two-fold. First, to (i) validate the pre-clinical application of our two novel compounds by conducting comprehensive in-vitro and in-vivo tests in mice as well as by carrying out experiments using human CMs. The second aim is (ii) to establish the business feasibility of our cardiac regenerative therapy concept by taking the necessary steps towards the commercialization of our novel compounds, focusing on the creation of strategic alliances with key private sector companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'More Money, Different Problems? Peoples’ Engagement with Politics during Good Economic Times' (ECONENGAGE) under Horizon Europe.

assistant: **Objectives**

Economic downturns can be a breeding ground for extremist politics. Yet, we know far less about how a good economy affects citizens’ interactions with politics. Despite massive wealth accumulation in established democracies, populism, misinformation, and group-based hostility continue to rise. Does national economic improvement affect the way people tune into politics and their commitment to democratic norms? ECONENGAGE fills this timely research gap by providing and testing an original theory on the impacts of economic improvement on the quality of people’s political engagement in established democracies. Starting with the point that improvement changes the stakes that people attach to politics, I will examine how this improvement affects their political information consumption, susceptibility to political misinformation, and the hardening of their ideological beliefs–all of which are central to democratic values – as well as their democratic attitudes.ECONENGAGE is organized into four work packages (WPs). WP1 uncovers the criteria that different individuals use to define economic improvement, using existing and original survey data. In WP2, I will further examine the theoretical mechanisms and generate testable hypotheses for how economic improvement affects people’s political information processing and degree of entrenchment in their ideological beliefs. WP3 tests these hypotheses with cross-national survey data in OECD countries and three experiments in Sweden and the UK, countries that differ markedly in economic and political institutions. WP4 investigates the broader impacts of economic improvement on the stakes people attach to elections, preferences for democratic decision-making rules, and commitment to ideological pluralism. ECONENGAGE will provide us with no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Tailoring Microstructure and Architecture to Build Ceramic Components with Unprecedented Damage Tolerance'.

assistant: **Concept**

Advanced ceramics are often combined with metals, polymers or other ceramics to produce structural and functional systems with exceptional properties. Examples are resistors and capacitors in microelectronics, piezo-ceramic actuators in car injection devices, and bio-implants for hip joint replacements. However, a critical issue affecting the functionality, lifetime and reliability of such systems is the initiation and uncontrolled propagation of cracks in the brittle ceramic parts, yielding in some cases rejection rates up to 70% of components production.The remarkable “damage tolerance” found in natural materials such as wood, bone or mollusc, has yet to be achieved in technical ceramics, where incipient damage is synonymous with catastrophic failure. Novel “multilayer designs” combining microstructure and architecture could change this situation. Recent work of the PI has shown that tuning the location of “protective” layers within a 3D multilayer ceramic can increase its fracture resistance by five times (from ~3.5 to ~17 MPa∙m1/2) relative to constituent bulk ceramic layers, while retaining high strength (~500 MPa). By orienting the grain structure, similar to the textured and organized microstructure found in natural systems such as nacre, the PI has shown that crack propagation can be controlled within the textured ceramic layer. Thus, I believe tailored microstructures with controlled grain boundaries engineered in a layer-by-layer 3D architectural design hold the key to a new generation of “damage tolerant” ceramics.This proposal outlines a research program to establish new scientific principles for the fabrication of innovative ceramic components that exhibit unprecedented damage tolerance. The successful implementation of microstructural features (e.g. textur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'LUMINESCENT IMPLANTS AS PORTS FOR LIGHT-BASED THERAPIES' in the context of a Horizon Europe call.

assistant: **Objectives**

A major difficulty in developing clinically useful treatments is to deliver therapeutic action with spatiotemporal precision and pharmacological specificity. This unmet need is exemplified in (1) neuropathic pain, which is due to abnormal inflammation and/or excitability of localized somatosensory nerves, sometimes resembling sudden stabbings or electric shocks, and in (2) epilepsy, a disease characterized by seizures that are due to a transient state of synchronized firing of a localized population of cortical neurons. Inflammation can be treated with photobiomodulation (PBM) but requires localized delivery of light. These conditions can be also treated with neuroinhibitory drugs (e.g. inhibitors of sodium channels, potentiators of GABAa receptors) but their systemic adverse side effects pose limitations to their safety and efficacy, and once administered, their activity cannot be controlled. To address this issue, we will use locally emitted light, which delivers anti-inflammatory action by PBM. It also allows turning on and off the pharmacological action of photoswitchable drugs locally and on demand. To illuminate the target sites in the body, we will develop PhotoTheraPorts, light-emitting implants based on upconverting nanoparticles. Their visible light emission can be controlled remotely and noninvasively with infrared light applied externally through the tissue and bone. Their encapsulation offers high efficacy and long-term tolerability. We will also develop suitable photoswitchable drugs with anti-inflammatory and neuroinhibitory activity, and we will preclinically test the efficacy and safety of both devices and drugs. We will demonstrate preclinically a novel treatment modality to reduce inflammation and neuroinhibition locally and on demand, in well-establi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Photonic Cluster States from Diamond' (PHOCLUDI).

assistant: **Concept**

The main objective of the proposed research project is to build a diamond-based single-photon source that is capable of emitting strings of entangled photons for resource-efficient photonic quantum computing. This addresses the main challenge of measurement-based quantum computing in realising scalable multi-photon quantum information processing. We will follow recent theoretical work to realise the generation of a string of single photons that are entangled as a cluster state – the generic resource for measurement-based quantum computing.To achieve this ambitious goal we will push current technology far beyond state-of-the-art by obtaining high light-collection efficiency from and advanced quantum control of single-photon emitters based on nitrogen-vacancy centres in diamond. To date, these light sources have been only used for obtaining individual, un-entangled photons. This will break new ground for the efficient generation of entangled photons, and will make large regions of previously inaccessible quantum state space available for modern quantum technologies.We will develop new theory to perform feasible quantum state tomography of the emitted light by using only passive optical elements. Furthermore, we will use new experimental methods for the implementation of quantum gates; the combination of fast electro-optical switches and high-efficiency superconducting detectors will enable adaptive measurements for error correction and deterministic quantum logic operations. The results of these experiments will be crucial in the development of scalable quantum computing in realistic scenarios, and open alternative perspectives for novel applications using quantum-enhanced information technology.