RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Epigenetics and microRNAs in Myocardial Function and Disease' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Heart failure (HF) is the ultimate outcome of many cardiovascular diseases. Re-expression of fetal genes in the adult heart contributes to development of HF. Two mechanisms involved in the control of gene expression are epigenetics and microRNAs (miRs). We propose a project on epigenetic and miR-mediated mechanisms leading to HF.Epigenetics refers to heritable modification of DNA and histones that does not modify the genetic code.  Depending on the type of modification and on the site affected, these chemical changes up- or down-regulate transcription of specific genes. Despite it being a major player in gene regulation, epigenetics has been only partly investigated in HF. miRs are regulatory RNAs that target mRNAs for inhibition. Dysregulation of the cardiac miR signature occurs in HF. miR expression may itself be under epigenetic control, constituting a miR-epigenetic regulatory network. To our knowledge, this possibility has not been studied yet.Our specific hypothesis is that the profile of DNA/histone methylation and the cross-talk between epigenetic enzymes and miRs have fundamental roles in defining the characteristics of cells during cardiac development and that the dysregulation of these processes determines the deleterious nature of the stressed heart’s gene programme. We will test this first through a genome-wide study of DNA/histone methylation to generate maps of the main methylation modifications occurring in the genome of cardiac cells treated with a pro-hypertrophy regulator and of a HF model. We will then investigate the role of epigenetic enzymes deemed important in HF, through the generation and study of knockout mice models. Finally, we will test the possible therapeutic potential of modulating epigenetic genes.We hope to further understand the patho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Support centres network for information technology in construction' (SCENIC) targeting Fourth Framework.

assistant: **Abstract**

The SCENIC project is an initiative to set up a business best practice network focussing on the Building and Construction Industry.This industry is a very fragmented one though the impact in the global economy is essential due to its amount of employment, its role in the global welfare of the society. It is a matter of fact that the use of I.T. in practice is low within the actors of this industry and this is contradictory with the huge amount of information handled during the whole life cycle of the products of this industry: the buildings where we all live and work everyday.A number of research projects are aiming at new advanced information systems for the Building Industry, developing standards and methods. They are led by large companies of the field. Nevertheless most of the companies of the field are small or very small. Their capabilities in taking up new technologies are very low. However, the dissemination of information, across a wide range of small to medium-sized enterprises, has been largely neglected.The SCENIC project aims at encouraging the adoption of advanced IT in the daily practice of the Construction Industry, especially the large number of SMEs of the sector :- bridging the gap between computer technologies and civil engineering and construction,- disseminating the available techniques and new emerging technologies- helping the SMEs to participate to the developments when necessary and at least to understand the strategic interests.The ultimate goal is to help less advanced parts of Europe to benefit of the most advanced techniques available somewhere in the European market. The network will provide the different organisations with this knowledge. Then it will help European practitioners to progress like the most efficient ones.This general goal w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Innovation in small capacity ammonia refrigeration plants (OSCAR)'.

assistant: **Innovation**

Objectives and problems to be solved: The defined proposal targets of research consider the huge challenges and current questions of top priority in social, environmental and life areas. At present the used refrigerants possess an Ozon Depletion Potential and / or a Global Warming Potential. Ammonia is a natural and non-polluting refrigerant. Ammonia refrigeration plants works energy-efficient. Them are built so far only for larger refrigerating capacity. An immediate commercial exploitation of project results is aimed at to ease the market entrance for innovative economical and non-polluting ammonia refrigeration systems of small capacity. This objective will be achieved by designing, manufacturing, installation, operation and measurement of 6 demo plants in Germany and Denmark within a period of 2 years. Project consortium consists of the project co-ordinator Dresden Kühlanlagenbau GmbH (DKA), a plant installer from Germany, and further plant installer (SME) compact kältetechnik GmbH (comp), Germany, SVK-Industry (SVK), Denmark, Buus Refrigeration (BUUS), Denmark, as well as the research institutes (RTD) DTI Arhus (DTI) from Denmark and ILK Dresden (ILK) from Germany. Description of the work: The German and Danish plant installer are active in different application areas. It allows to cover the whole application range of small ammonia refrigeration plants. In detail, the following demo plants with the refrigerant ammonia or ammonia/DME will be manufactured, representing also the wide spectrum of applications and considering several types and circuits of refrigeration plants, various operating conditions, capacities and appropriate main components, as well as diverse connection techniques and materials: in Germany one refrigerating unit for normal cooling cells and one
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Cellular And Molecular Mechanisms Of Cross-Presentation In Epitope Spreading Following Immune Responses To Anti-Tumor Vaccines'.

assistant: **Objectives**

Significance: Combating major diseases, such as cancer, is an important objective in the area of Life Sciences in the 6th Framework Programme. The challenging goal of vaccination in cancer-bearing patients is to induce long-lasting antigen-specific immunit y to protect the host against tumor establishment. Although in several cases tumor rejection in mice as well as in humans has been reported, the results of current tumor immunotherapy protocols are still disappointing. Background: We propose to study epito pe spreading (ES), a process whereby epitopes distinct from an inducing epitope (e.g. a vaccine) become targets of an evolving immune response. Only recently, ES was found to play a role in anti-tumor immune responses and in tumor regression following anti -tumor vaccinations. It is thus conceivable that ES can be exploited to make anti-tumor vaccines more efficient. However, the cellular and molecular mechanisms of ES are largely unknown.Dendritic cells (DC), pulsed with tumor peptides, have been used as an ti-tumor vaccines. DC induce some immune responses by cross-presentation, which seems to depend on the fusion of phagosomes with the endoplasmic reticulum and on the association of immunoproteasomes with phagosomes.Methods: We will establish a mouse model for ES following anti-tumor vaccinations by peptide-pulsed DC. We will use this model to study (a) the role and mechanisms of cross-presentation in ES, (b) ES in wild-type versus immunoproteasome-KO mice and (c) specific requirements for the processing and the nature of the tumor antigen. Our in vivo experiments will be complemented by in vitro studies to assess the cell biology of ES by microscopic techniques.Prediction: Our proposed experiments will elucidate cellular and molecular mechanisms of ES and th us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multi-leg precision calculations and advanced phenomenology in the LHC era' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The Large Hadron Collider (LHC) running actually at CERN, Geneva, is the most powerful man made high energy particle collider.  It will enable us to observe or exclude the Standard Model Higgs boson, to clarify the nature of the electroweak symmetry breaking (EWSB) and to find possible signals of physics beyond the Standard Model (SM).Search for new physics signals at the CERN LHC frequently involves multi-particle final states, consisting of jets, leptons, photons and missing energy. Meaningful searches for these signatures require not only a very good knowledge of the expected signal, but also of all the SM backgrounds yielding identical final state signatures. Since leading-order calculations are affected by large uncertainties, next-to-leading (NLO) order corrections are necessary. For a long time, these corrections were available only for at most three final state particles. The current frontier of complexity are NLO calculations of 2 -> 4 reactions.The aim of this project is to carry out, on the one hand, several phenomenological studies of relevant processes for Higgs discovery and new physics searches at the LHC for 2 -> 4 processes at the one loop level. We will perform novel NLO QCD calculation of several multi-leg processes involving vector bosons and the top quark.   On the other hand, we propose a novel technique to compute diboson production channels at approximated NNLO accuracy.The timeless and relevance of the project is given by the running of the LHC.  We will release all the calculations as a Monte Carlo program to be used by the experimentalist to analyse data. The project will be performed at IFIC, a world leader centre for theoretical and experimental research in particle physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanophotonics for Quantum Information and Simulation' under Seventh Framework.

assistant: **Concept**

The growth of classical computational power supported by continued size reduction is expected to find its limit around 2019, when devices will probe the atomic scale. Fortunately, this limit represents an opportunity as systems are ruled by quantum mechanics that may lead to more efficient computation techniques. Many systems have been proposed as candidates to implement quantum computers: trapped ions or cavity and circuit QED,... However, still none of them has emerged as a definite full-fledged and scalable quantum computer. The shortcomings imposed by classical computation appear to be especially critical when studying quantum mechanical systems, since the computational complexity increases exponentially with the system size. To deal with the intrinsic computational complexity of quantum mechanics, without recurring to quantum computation, Feynmann proposed to use quantum systems, already ruled by quantum laws, as analog quantum simulators.In this project, NanoQuIS (Nanophotonics for Quantum Information and Simulation), the applicant will study the possibilities for quantum information and simulation of one promising emergent platform, namely, atoms interfaced by photonic crystals. First, within a semiclassical framework, dielectric structures in one and two dimensions will be designed in order to trap atoms and induce special interactions between them. Then, it will be explored the different hamiltonians and open dissipative evolutions that can be engineered within these structures, to use them for both quantum information and simulation. Particular emphasis will be made in models with long-range interaction, e.g., quantum chemistry problems, due to their important practical implications. Together with the theoretical effort, the proposal aims at creating close col
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spatio-Temporal Modeling for Enhanced Automated Detection and Classification of Non-Mass Lesions in Breast MRI' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The emphasis of this project lies in the development and evaluation of an intelligent and robust computer-assisted system for detecting and diagnosing breast lesions that present a non-mass-like enhancement and thus lead to a substantial improvement of the quality of breast MRI postprocessing, reduce the number of missed or misinterpreted cases leading to false-negative diagnosis, and avoid unnecessary biopsies for benign lesions or observation for malignant lesions.Non-mass-enhancing lesions represent a diagnostic challenge in breast MRI because of the high variance in morphological and kinetic characteristics and have a lower reported specificity and sensitivity than mass-enhancing lesions. Existing image analysis techniques have proven to be insufficient to capture the unique spatio-temporal behavior of these lesions and aid in the automated differential diagnosis of these lesions. We propose to develop, test and evaluate novel techniques for the detection and diagnosis of non-mass-like enhancing lesions and validate them in three specific experiments that will lead to a substantial improvement in diagnostic accuracy and efficiency.The mobility proposed in this project is for Prof. Anke Meyer-Baese, an expert in the field of pattern recognition techniques in medical imaging, to expand her skill set and research portfolio while working on a novel computer-aided diagnosis system for challenging breast lesions at the University of Maastricht, Department of Radiology in Netherlands. Prof. Meyer-Baese is a Full Professor at Florida State University, USA.  A number of specific knowledge transferobjectives are outlined in this proposal. This project will have a strong impact on the European Research Area (ERA) through its innovative research goals, focused knowledge transfe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MINIaturitzed coherent soft X-ray source for research and industry' to be submitted under Horizon 2020.

assistant: **Abstract**

X-rays are a prime analytical tool across a diverse range of areas in our modern economy—from fundamental physics and chemistry research, to the pharmaceutical and semiconductor industries. In particular, sources of ultrafast coherent x-rays are expected to have a transformative impact in all of these areas due to their capacity to enable the study of interactions between charge carriers and atoms in gases, liquids and solids, in real-time, and with element specificity. Ease of use, compactness and price will prove vital for any new X-ray technology looking to find use in industrial applications. “miniX” will address all of these issues with the miniaturization of a laser-based soft x-ray source, designed for lay user operation and at low cost.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Holography and Neutron Stars' (HoloNS).

assistant: **Concept**

My research project aims at using holographic methods to acquire insight into the properties of dense matter in the core of neutron stars. The latter are hard to predict due to the strength of interactions, that requires non-perturbative methods. A promising approach that is able to produce unambiguously non-perturbative results, is given by the holographic correspondence. In this project, I will apply the holographic correspondence in the regime of dense matter, with two main objectives. My first goal is to determine the phases of neutron star matter in holography. I will construct the holographic dual of dense baryonic matter, and extract relevant physical properties, including the neutron star equation of state, and the location of the transition to deconfined quark matter. I will also include the effects of isospin imbalance, to determine whether or not it can generate mesonic condensates in the core of neutron stars.My second objective is to understand the transport properties of dense holographic matter. These properties are relevant for neutron stars dynamics in a merger or during a supernova. In such events, the evolution contains two components : the strongly coupled baryonic matter that equilibrates fast, and is thus controlled by hydrodynamics, and the neutrino fluid, which is typically out of equilibrium. Both the hydrodynamics of the baryonic medium and the neutrino transport will be investigated.My results will be compared with available experimental constraints, and existing models proposed for the description of dense matter.


**Keywords:** holographic QCD,  neutron-stars,  dense nuclear matter,  phases of QCD,  QCD transport,  neutrino transport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ash for the future: defining european ash populations for conservation and regeneration' (FRAXIGEN).

assistant: **Concept**

The FRAXIGEN project will strengthen the scientific basis for the sustainable conservation and regeneration of ash genetic resources in Europe, through improved understanding of three native Farinas species. Genetic structure and gene flow among natural European populations, and the influence of the reproductive system, will be studied in detail . This, combined with trials to investigate the distances over which environmental adaptation occurs , will provide a rational basis for defining 'local ' populations (as required by EU directives) as well as insights into (a) the resilience of populations to potential global change, and (b) how anthropogenic selection has affected adaptive variation. Partners from northern and southern Europe will collaborate closely to deliver scientifically-based guidelines for defining provenances and selecting sustainable seed sources. Dissemination methods will include a website and regular meetings with end users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Metagenomics of the Human Intestinal Tract' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. Our proposal focuses on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We shall implement and integrate the following activities: (i) creation of a reference set of genes and genomes of intestinal microbes, using high fidelity metagenomic sequencing and full genome sequencing of selected bacterial species; (ii) creation of the generic tools, based on the high density DNA arrays and novel ultra-high throughput re-sequencing techniques, to study the variation of human gut microbiota; (iii) use of the tools to search for correlations between the genes present in the gut microbiota and disease, focusing on the inflammatory bowel disease and obesity, the two pathologies of increasing social relevance in Europe; (iv) study of the genes correlated with the disease, both in terms of their function in microbes and their effect on the host, with the focus on host-microbe interactions; (v) development of an informatics resource to store and organize the heterogeneous information generated within the project, such as gene and genome sequences, gene frequencies in healthy and sick individuals or gene functions and also enriched by information relevant to human gut microbiota from the outside of the project; (vi) creation of the bioinformatics tools to carry out the meta-analysis of the information; (vii) creation of an interface with the stakeholders, including an international board to promote cooperation and coordination in the human metagenome field, and general public. Our project will pl