RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Parental care: shaped by parent–offspring conflict and co-adaptation' (2007-2013).

assistant: **Concept**

Interactions between caring parents and their offspring are among the most widespread and fundamental social behaviours. Surprisingly, however, the underlying genetics, even of well-studied model systems, are largely unknown. Traditionally, behavioural ecologists studying the evolution of parental care have typically focused on how evolutionary conflict between parents and offspring has shaped parental provisioning and offspring solicitation behaviours, while ignoring the underlying genetic mechanisms. Recently, a quantitative genetics perspective has emerged that aims to explicitly model and measure the quantitative genetics underlying parent–offspring interactions, and which emphasises the potential importance of co-adaptation of offspring demand and parental supply in the evolution of parent–offspring interactions. Such parent–offspring co-adaptation is predicted to lead to genetic covariation between parental provisioning and offspring solicitation behaviours. The co-adaptation hypothesis furthermore predicts the presence of fitness costs to parents and/or offspring if the phenotypic correlation between parental and offspring behaviours is disrupted – causing a mismatch between the behavioural responses of parents and offspring. However, few empirical studies have tested these ideas, and the fitness implications and underlying genetics of parent–offspring conflict and co-adaptation are virtually unknown. We propose to integrate approaches from behavioural ecology and quantitative genetics in an ecological setting to remedy this situation: we will investigate the genetics and fitness implications of parent–offspring conflict and co-adaptation in wild blue tits (Cyanistes caeruleus), which are an ideal model for this purpose. The research outcomes will improve our und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Brain fluids - Transport and clearance' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Scientific breakthroughs in neuroscience explain the need for sleep and the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases in terms of fluid dynamics: the waste created during the day is cleared away as we sleep or it accumulates. However, a decade of research after the original theory was posed has revealed that the underlying physical mechanisms are still not understood and that the advanced mathematical tools are needed.In this project we propose a research program addressing 1) new fluid dynamics mechanisms, 2) novel numerical analysis for advanced multi-physics brain simulations, and 3) a framework for patient-specific simulations. We will exploit  reduced order and machine learning methods in addition to finite element solutions.  Withsuccessful delivery, the ""aCleanBrain"" will establish the main drivers of brain fluid dynamics, provide a foundation for accurate, efficient and robust algorithms for multi-physics problems and develop a software framework for advanced biomechanical brain simulations.""


**Keywords:** multilevel, multi-physics, preconditioning, glymphatic system, computational physiology, biomechanics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology.' in the context of a Horizon 2020 call.

assistant: **Objectives**

A diverse variety of medical or lifestyle conditions lead to a progressive loss of muscle force by functionally impairing myofibril contractility and causing ultimately myofibril loss. Major underlying risk factors of chronic muscle force loss are ageing, inactive lifestyles, and unbalanced nutrition. Together, these factors are predicted to lead to an endemic incidence of muscle weakness both in the developed countries. Clinical research on the mechanisms involved requires a multidisciplinary approach covering aspects of ageing, metabolism, and on the humoral cross-talk of muscle with other key organs including heart, liver, kidney, and lung.  To achieve this, six European groups with complementary expertise in inter-organ-cross-talk during stress-induced secondary myopathies will team-up with three leading teams in the U.S. with expertise in myopathy animal models, myofilament proteins and translation of muscle research into therapeutic interventions, and with one team from South Africa with cutting-edge expertise in the regulation of regenerative capacities in muscle. Importantly, five SMEs will participate in this RISE network that provide expertise in early muscle disease detection, monitoring, and the developing preventive strategies: Their knowledge on muscle disease detection at early stages and their monitoring during interventions will promote translational innovation. To implement innovation and our joint research program, both early stage and advanced researchers will be seconded from the academic nine teams to these five SMEs and vice versa. Thereby, this RISE scheme will establish a long-term collaborative University-SME driven translational innovative research program innovation in our interdisciplinary field of growing socioeconomic medical importance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Explanatory Models and Public Understanding: The Debate between Science and Religion 1800-1918' (1998-2002).

assistant: **Concept**

The authority of scientists in society has increased to the point where their views dominate decision- making both public and private. The period under consideration, in effect the long nineteenth century, saw the essential steps taken towards this state of affairs.The increasing success of scientific explanation and invention was essential; but the struggle with the then dominant authority of the Church, and of religious philosophy, was the decisive factor in the change. In this process, scientists came to the fore not only as discoverers of new truths, but as founders and leaders of institutions, and as conscious public representatives and spokesmen for the scientific worldview.The present Conference project proposes to examine the emergence of the figure of the scientific leader as it emerged in the course of the nineteenth century, from anonymous and low-status toiler to acknowledged leader of a high-profile community. Often this process included the career change from scientific work to the development of new associations, institutions, and of new genres of communication - the pubic lecture, the public debate, the travel description in which scientific results were leavened by personal narrative and illustration, the popular-scientific essay, the general reflections on nature and society - that met the needs of a better educated general public being prepared for political responsibility. The leader took on a variety of functions formerly carried out by other authority figures.It is envisaged to submit a proposal for a second Conference at a later stage. It would be closely related to this empirically oriented study, in that it would look at the cogency and adequacy, as well as the persuasive strategies, of the structures of argument employed by these figures in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of quantitative and qualitative molecular biological methods to identify plant and animal species in foods' under Fifth Framework.

assistant: **Concept**

Recent investigations demonstrated that fraudulent replacement of food components as well as adverse reaction to unexpected food ingredients is quite common problems. Up to now official methods for the detection of plant and animal species in foods are exclusively based on protein analysis. The project aims to develop DNA-analytical methods for qualitative and quantitative identification of plant and animal species in foods to monitor product safety and tractability. The project includes the comparison of nucleic acid-based methods with protein-based ones. A research aspect will be enhancing throughput by introducing multiplex-PCR, PCR-ELISA and chip technology. Four methods for several species will be validated in interlaboratory studies. Furthermore a public database will be established containing information about methods to identify plant and animal species in foods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pervaporation and Nanofiltration with Ionic Liquids' to be submitted under Sixth Framework.

assistant: **Abstract**

The aim of this proposal is to combine the recent development in the field of membrane technology, e. g. in nanofiltration, supported liquid membranes and pervaporation, with the use of ionic liquids (ILs) for providing novel solutions in downstream process sing or process intensification.ILs are currently explored as new reaction media for chemical synthesis or electrochemical applications and have emerged as a new class of solvents in the last decade. ILs seem to have a large potential in downstream process sing, especially when applied in a form that requires only a small amount of them, e.g. in supported liquid membranes.The special property of ILs is their non-measurable vapour pressure at ambient temperature that makes their application in liquid membrane s attractive for pervaporation. Simultaneous determination of solute transport through ionic liquids as supported liquid membrane is one of the preconditions of understanding of this new process.After the generalization, the valuable experimental data can be used both for the preparation of new pervaporation membranes based on ionic liquids and for the increase of the efficiency of the separation process and protection of the environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterisation of early cellular and molecular alterations leading to inflammation and HCC using a mouse model with liver cell-specific NEMO ablation' to be submitted under Seventh Framework.

assistant: **Abstract**

Chronic liver inflammation has been shown to promote hepatocellular carcinoma (HCC). However, the initial cellular and molecular events that trigger the inflammation are largely unknown. The proposed study will provide a detailed characterisation of cellular processes that need to be deregulated in liver cells to cause inflammation. For this purpose, a genetic mouse model that closely reproduces all the stages of inflammation-related HCC will be used. This mouse exhibits a Liver Parenchymal Cell specific NEMO ablation (NEMOLPC-KO), the regulatory subunit of the IKK complex that activates NF-kB signalling.The two main goals of the proposed project are to a) unravel early cellular and molecular alterations in the liver cells of NEMOLPC-KO mice, and distinguish these resulting from a cell-autonomous effect of NEMO deletion from those resulting from a non-cell autonomous effect due to the inflammatory microenvironment and b) distinguish between NF-kB-dependent and independent functions of the NEMO/IKK complex in liver homeostasis.Two experimental strategies will be used to achieve these goals. The first is a targeted examination of specific cellular processes that could be implicated in the development of liver inflammation, such as the mitochondrial functions, ER stress, autophagy, and p62 functions. A combination of mouse genetics with cutting-edge microscopy and other cell biology techniques will be employed. The second involves high-throughput approaches, such as gene expression microarray, that will help distinguishing between the above-mentioned NEMO functions.The scientific impact of this study will be to define early cellular changes can disrupt liver cell homeostasis resulting in human liver inflammatory diseases, thus helping in development of new therapeutic appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Diverging Destinies: Introducing the Role of Social Environment and Genetic Sensitivity in the Effects of Family Instability'.

assistant: **Objectives**

Today a substantial share of children experience their parents to separate or divorce, to re-partner with someone new, and potentially have children with this new partner. Whereas we know that such family instability has detrimental consequences for children’s behavior and mental health, it remains unclear the degree to which these negative effects are unevenly distributed. In order to disentangle this question, this project investigates the role of social environment and genetic sensitivity in the effects of family instability from a cross-disciplinary perspective. The project uses new and unique data and combines insights from the social and the developmental sciences in order to advance knowledge on three connected issues:1. Do negative effects of family instability vary for children born into different family structures, and among children experiencing multiple transitions in family structure during childhood?2. Are negative effects family instability augmented among children with fewer resources available in their social environment?3. Are negative effects of family instability concentrated among children with greater genetic sensitivity?It is important to improve our understanding of heterogeneity in effects of family instability because it allows us to more effectively address barriers to children’s’ development and families’ social mobility. The results from this project will help explain why some children overcome the experience of social disadvantage while others don’t. Thereby this project helps to better tailor interventions and programs serving children and families, and thus reduce children’s negative outcomes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Forced Vibration Testing and Seismic Fragility Assessment of Instrumented Structures' (FORAGAINST).

assistant: **Concept**

The objectives of this proposed research are to perform forced vibration tests on the following reinforced concrete structures, which are permanently instrumented for recording their dynamic responses in the case of future earthquakes in Turkey: a four-story dormitory building in Bolu, a four-story office building in Istanbul, a five-story hospital building in Antakya, a three-story school building in Antakya, and a four-story university building in Izmir, and to derive seismic fragilities for these structures to evaluate their seismic vulnerability. The structural dynamic properties identified from the forced vibration tests will be used in validating or calibrating the-state-of-the-art finite element models of these structures. These structural models will then be used in developing probabilistic seismic risk assessment tools in the form of fragility curves for these permanently instrumented structures. The end-product of this study, the seismic fragilities, will serve the building owners and local authorities in pre-earthquake planning to mitigate probable losses and in post-earthquake planning to develop emergency response and recovery strategies in earthquake prone regions of Turkey.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Phosphorus influence on steel ageing' (PISA) targeting Fifth Framework.

assistant: **Abstract**

The integrity of the pressure vessel is vital to the safe operation of a nuclear reactor. It is therefore necessary to monitor or predict the changes in the pressure vessel material during operation. Exposure to irradiation (or elevated temperatures) causes the segregation of phosphorus to internal grain boundaries in RPV steels. This, in turn, encourages brittle intergranular failure of the material. The objectives of PISA are to improve predictability of a failure mechanism that can affect all types of reactor plant operating in Europe, and in particular to improve the predictability of mechanical property changes in long- service steels for plant applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Controls on knickpoint migration and consequences for landscape evolution: experimental and numerical modelling' (WaterfallModel3D) under Horizon 2020.

assistant: **Objectives**

As the link between the fluvial network and hillslopes, bedrock channels mediate the response of the landscape to changing boundary conditions, such as tectonics and climate through migrating ‘knickzones’ or ‘knickpoints’, yet the complexities of the mechanisms of knickpoint retreat are often ignored in studies of landscape evolution. This fellowship aims to understand the controls on knickpoint retreat rate and explore the implications for landscape evolution (e.g. channel-hillslope coupling) and other processes that respond through an ‘upstream incision wave’ such as gully erosion, using a range of complementary experimental and numerical modelling approaches. The experimental modelling will isolate the impact of different controls (discharge, knickpoint erosion mechanism, bedrock strength, sediment flux) on knickpoint retreat which will be used to develop an understanding of the key factors that can be used to predict knickpoint retreat through landscapes. This understanding will then be implemented in the numerical landscape evolution code €ros, through the adaptation of the parameters that control knickpoint retreat (currently based on the stream-power incision model assumption that knickpoint retreat scales with drainage area). The model will be run on several mountain landscapes ranging from areas where previous work has identified a strong correlation between knickpoint retreat rate and discharge/drainage area (e.g. New Zealand) to study areas where other factors are thought to be more dominant in controlling the retreat rate (e.g. Iceland). This will improve the understanding of how these landscapes have responded to changes in past changes tectonic/climate forcing, and can also be used to predict how the landscapes will respond to future transient forcing over
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modulation of gene expression by platinated oligonucleotides' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

-To modulate gene expression at transcription and translation levels by steric blocking of cellular machinery by means of irreversibly and specifically linked platinated oligonucleotides-To elucidate the mechanism of the interstrand cross-linking reaction between the platinated oligonucleotides and their targets-To achieve an automated synthesis of platinated oligonucleotidesTo make transplatin-modified oligonucleotides efficient to sterically block the cellular machinery and thus to modulate specifically gene expresion, we take advantage of the participants'expertise in chemistry of platinum(II) complexes and oligonucleotides, physical-chemistry of platinated oligonucleotides, biochemistry and biology of cells. The oligonucleotides will be irreversibly and specifically cross-linked to their targets. The cross-linking reaction of the platinated oligonucleotides to their targets is triggered by the formation of the double or triple helices between the platinated oligonucleotides and their respective targets. Three main complementary research lines will be followed.-1). The rearrangement of trans-DDP-1,3-intrastrand cross-links into interstrand cross-links promoted by double helices will be tested in cells (trans-DDP is for trans-diamminedichloroplatinum(II)). The rearrangement of the trans-DDP-1,3-intrastrand cross-links promoted by the binding of the platinated oligonucleotides to duplexes with formation of triplexes, will be studied.-2). The pairing of an oligonucleotide containing a trans-DDP-monofunctional adduct with its complementary strand, results in the formation of an interstrand cross-link. We will study the interstrand cross-linking reaction in triplexes. This work, initially done with trans-DDP-monofunctional adduct, will be extended to other platinum(II) co