RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GROW Observatory', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The GROW Observatory (GROW) will create a sustainable citizen platform and community to generate, share and utilise information on land, soil and water resource at a resolution hitherto not previously considered. The vision is to underpin smart and sustainable custodianship of land and soil, whilst meeting the demands of food production, and to answer a long-standing challenge for space science, namely the validation of soil moisture detection from satellites. GROW is highly innovative project leveraging and combining low cost consumer sensing technology, a simple soil test and a large user base of growers and plant enthusiasts to contribute individual soil and land data. It is designed to engage primarily individual growers and small-scale farmers across Europe, and to enable them to develop new wisdom and innovative practices through the collective power of shared and open data and knowledge. Citizens contributing data will gain access to the first single-source comprehensive crop and watering advice service for individual and small-scale growers incorporating scientific and crowdsourced information. Moreover, they will develop ‘campaigns’ (coordinated sampling operations) around local needs and issues, to underpin smarter decision-making and implementation of policy objectives. GROW will actively identify and enable new and credible social and business innovation processes, creating potential new services, applications and markets. The outcome will be a central hub of open knowledge and data created and maintained by growers that will be of value to the citizens themselves as well as specialist communities in science, policy and industry. The GROW partnership will connect and scale to globally dispersed communities linked through digital and social platforms, and a w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Absorption spectrsocopy and hyperspectral tomography based on coherent supercontinuum source'.

assistant: **Concept**

This proposed research program aims to develop a versatile chemical sensing system based on a novel coherent supercontinuum (SC) laser source and absorption spectroscopy. Compared with the traditional SC sources, this new version takes advantage of all normal dispersion photonic crystal fibres (PCF) for the first time to suppress spectral noise and intensity fluctuations. As a result, averaging of absorption spectra can be minimized and temporal resolution can be greatly enhanced. The system is designed to possess two operational modes, which are the line-of-sight-averaged and tomographic modes respectively to satisfy various application needs. The line-of-sight-averaged mode is more suitable for situations where the temporal resolution is the first priority, for example, a rapid changing turbulent flame with insignificant non-uniformities in combustion field. On the contrary, the tomographic mode is targeted to maximize the spatial resolution and is a better option for scenarios where non-uniformities cannot be neglected such as steady laminar flames with large gradients in temperature and chemical species distributions. The implemented system will be verified on a flat burner which has been calibrated and well understood. The sensing system will be finally applied to a rapid compression machine (RCM) to simultaneously retrieve the temperature and concentrations of multiple species with ultrahigh repetition rate (on order of MHz). The purpose of this application is to obtain detailed insights during the ignition and combustion processes of homogeneous mixtures. Species of interest include e.g. acetylene C2H2 as a precursor of soot formation, H2O for temperature measurement, CO as an indicator of heat release, and the formyl radical CHO as an indicator for start of igni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Boosting Innovation for COVID-19 Diagnostic, Prevention and Surveillance.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The novel corona virus causing COVID-19 overwhelmed Europe and the world in just a few weeks’ time. Small and Medium-sized Entrerprises (SMEs are put at very high risk by the slowdown or shutdown of economic life in their countries – exactly those companies who ensure the development of innovative solutions urgently required for counteracting the impacts of COVID-19 and for helping to control possible future outbreaks alike. In view of this situation, accelerated uptake of innovative technologies to tackle COVID-19 is most needed. In order to give an efficient and fast answer to this challenging situation, we propose building an Innovation Hub for the addressed technologies: an innovative open access platform to offer companies and reference laboratories the capabilities, expertise, networks and services required for the assessment, development, prototyping, testing, scaling-up, pilot production and market exploitation of innovative technologies to tackle COVID-19 pandemic. This approach will be based in the Open Innovation Test Beds (OITBs) concept, to incorporate lessons learned from those Innovation Actions, reducing time for putting in place such HUB and ensuring its successful implementation for a swift impact to the current situation. Our approach will include leading applied research and innovation centers in Europe, together with entities specialized in building OITBs, and reference clinical sites.INNO4COV19 will provide funding to third parties to help them achieve the desired objectives. Presence of leading applied research EU institutions in the Consortium will help to obtain a huge impact and to find and attract innovators across Europe to offer new solutions for COVID-19 pandemic and other potential future outbreaks. Europe needs to reinforce its technologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Wearable Integrated Soft Haptic Display for Prosthetics' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In this ERC Proof of Concept, we want to develop a wearable fluidic force feedback device for upper and lower limb prostheses, composed by soft silicone chambers along with their actuation and control units, to exert pressures in multiple specific stump sites. This solution, named Wearable Integrated Soft Haptic device (WISH), strives to achieve both good modality matching (MM) and somatotopic matching (SM), while keeping non-invasive and practicable. The principle, preliminarily demonstrated on a single subject and one prosthesis type to display one type of force/tactile information, has the potential to generalize in several directions. Our goal is to transform WISH into a technology platform supporting different devices for different types of prosthesis available in the market, for both upper and lower limbs. We will depend on user involvement, team with hospitals and rehabilitation units, and work with companies producing prostheses (see endorsement letters) to acquire domain specific knowledge and to test our devices in real use cases. Through this project, our Technology Readiness Level will increase from 3 to 4/5 and enable us to apply for an EIC Transition for subsequent development and validation in a larger cohort. To the best of our knowledge, no other haptic display technology for prosthesis users has ever reached such maturity and readiness level, which makes this opportunity unique.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The role of hypoxia-inducible factors in human haematopoietic stem cell biology and leukaemogenesis'.

assistant: **Innovation**

Mammalian haematopoiesis in the adult takes place predominantly in the bone marrow (BM) where a population of haematopoietic stem cells (HSC) are located. HSC are able to self-renew and give rise to all the blood cell types. The fate choice of HSC to either self-renew or differentiate is controlled by an interplay between intrinsic mechanisms and extrinsic signals from the surrounding environment called stem cell niche. The existence of a hypoxic niche in the BM has been highlighted in the last decade. It has been proposed that the most quiescent HSC reside in the most hypoxic areas in the BM suggesting that low oxygen levels might play a key role in the maintenance of HSC. However the molecular mechanisms by which HSC respond to hypoxia have not been elucidated. Cells have developed a molecular mechanism for oxygen sensing. An important mediator is the transcriptional complex hypoxia-inducible factor (HIF). At low oxygen levels, HIF is stabilized and regulates the transcription of crucial genes involved in cell proliferation, survival and differentiation. Under normoxia, HIF has a low transcriptional activity. In addition, HIF has been reported to be upregulated in certain pathological conditions such as cancer where a high expression of HIF correlates with a poor prognosis. The aim of this project is to understand the molecular mechanisms by which human HSC response to their hypoxic environment. I will address this question by studying the role of HIF in HSC. I will first concentrate on analysing the consequences that genetically manipulating HIF might have on HSC in vitro and in vivo. Secondly I will analyse whether HIF is upregulated in leukemic stem cells (LSC) and in such a case, I will finally investigate the consequences that downregulating HIF might have in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Uptake of Solid Bioenergy in European Commercial Sectors (Industry, Trade, Agricultural and Service Sectors) – Bioenergy for Business'.

assistant: **Objectives**

A consortium led by the Austrian Energy Agency (AEA) developed the project ""Uptake of Solid Bioenergy in European Commercial Sectors (Industry, Trade, Agricultural and Service Sectors) – Bioenergy for Business"" for the EU-Programme Horizon 2020’s Call 2014 (LCE14). The project partners include a combination of energy agencies, national biomass associations and research-oriented partners with specialized knowledge on biomass from Northern, Southern, Central and Eastern Europe (Finland, Denmark, the Netherlands, European Biomass Association (AEBIOM), Germany, Austria, Slovakia, Croatia, Greece, Poland, Romania, Bulgaria and Ukraine). The goal of this project is  to support and promote the  (partial) substitution of fossil fuels (coal, oil, gas) used for heating, by available bioenergy sources (industrial wastes, forest biomass, straw and other agricultural biomass) in the partner countries and beyond. In this context, the project will contribute to increase much-needed security of energy supply through lower dependence on fossil fuels from politically volatile sources. Target groups are, on the one hand, owners and operators of industrial heating plants (for private or district heating). On the other hand, actors who play an important role with regard to the value chain and to framework conditions crucial for the use of bioenergy heat will also be involved. Activities will be tailored to the needs of actors relevant to promising market segments in the industrial, commercial, services and agriculture sectors. Results of the project will include information about market potentials, capacity building/training, decision-support tools and communication activities targeted at relevant stakeholder, tools to support the careful assessment, planning and implementation of such pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Structural enzymology: real-time tracking of enzyme catalysis in crystals' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The use of single crystal UV/Vis and fluorescence spectroscopy has revolutionised the field of structural enzymology which takes advantage of the fact that many proteins retain their catalytic activity in the crystalline form and by soaking in substrates and substrate analogues it is possible to observe turnover in the crystal. In protein systems which undergo spectral changes in the UV or visible regions, single crystal UV/Vis spectroscopy can be used to track the formation of the intermediates thus generated. This information can be combined with fast-freeze trapping techniques to allow X-ray crystallographic structure determination of precisely identified reaction intermediates.The current state-of-the-art is limited, however, to those systems with accessible chromophores. Recently, a single crystal Raman microscope has been described which allows, for the first time, real-time tracking of catalysis in crystalline proteins which do not possess UV or visible chromophores. However, the microscope setup is not ideal for the use of rapid freeze trapping techniques, as the crystal is suspended in a droplet of liquid over a sealed well. In this application, a new open-plan single crystal Raman spectrophotometer is proposed that is specifically designed to facilitate the use of rapid freeze trapping techniques for structural enzymology studies. The use of Raman spectroscopy opens the door to the application of cutting edge structural enzymology techniques to a greatly expanded range of biological systems, including those of medical and biotechnological importance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Sustainable station-keeping systems for floating wind'.

assistant: **Objectives**

To meet EU net zero targets requires a six times increase in offshore wind deployment rate, primarily in deep seas where floating offshore wind (FOW) is needed. To achieve this growth requires FOW to be economic, sustainable and supported by a wide supply chain. TAILWIND is focussed on station-keeping systems of FOW, which comprise mooring lines and anchoring systems. The project will unlock identified opportunities for cost reduction, reduced environmental impact and material use, and also supply chain diversification.TAILWIND will integrate new experimental evidence, novel technologies and innovative methodologies, across mooring lines and anchors, and will quantify the resulting benefits for the overall floating system design. All innovations will be sustainable-by-design, integrating environmental, societal and economic benefits. For mooring lines, new synthetic rope technologies will be mechanically and chemically tested to demonstrate their suitability for small-footprint ‘taut’ moorings, validating new response models. For anchoring, geotechnical centrifuge testing and advanced soil element testing will underpin two advances: (i) new response models for the long-term loading particular to FOW, and (ii) the validation of novel anchors types including cluster anchors that are “silently” installed from small vessels and are suited to shared moorings. The new technologies for mooring lines and anchors will allow smaller and lighter station-keeping systems, manufactured and installed by a wider supply chain. TAILWIND will distill the models into system optimisation tools, unlocking further floater optimisation and cost reduction. Finally, an integrated life cycle assessment will quantify the economic, social and environmental impact of TAILWIND’s technologies.TAILWIND
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'On-chip model of mucociliary clearance for the design of drug formulations aimed at chronic respiratory diseases' (MuST).

assistant: **Concept**

Chronic respiratory diseases (CRDs) caused 4 million deaths worldwide in 2019. CRD treatments are often administered by inhalation in particulate formulations. However, mucociliary clearance (MCC) acts as an effective physical barrier that prevents drugs from reaching the target cells. This mechanism relies on the beating of cilia on the bronchi surface, which allows the displacement of the overlying mucus layer. Inhaled drugs are thus trapped by the mucus and quickly evacuated from the airways.The objective of the MuST project is to model the mechanism of MCC using a microfluidic chip, to assess drug penetration through the moving mucus and thus provide a screening platform for new drug formulations. Our main objective can be subdivided into three research objectives: 1) Develop an adequate synthetic mucus model; 2) Reproduce the mucociliary clearance mechanism on a microfluidic chip; 3) Screen innovative drug formulations using our chip.In this project, we combine expertise in biophysics, physical chemistry, soft condensed matter, and nanomedicine. The originality of our approach lies in 3 key aspects: 1) We will develop a synthetic mucus model that reproduces all the properties of native human mucus; 2) We choose to design a non-cellular MCC model, which will provide an easy, quick, cheap, and reproducible alternative to cell-based MCC models; 3) We will apply an original technique called differential dynamic microscopy (DDM) to characterize the drug behaviour in the chip. DDM is perfectly adapted to measure particle diffusion in biological hydrogels under flowing conditions.Our innovative screening platform will pave the way to design more efficient formulations to treat CRDs, with higher delivery rates, thereby improving the available treatments and lowering their
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The development of an integrated waste recycling system' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Municipal solid waste within the European Union presents a formidable problem, with over 200M tonnes of waste being produced annually and requiring treatment. The work proposed by the Consortium of SMEs in this project is aimed at providing a viable alternative to landfill and incineration for a significant percentage of municipal solid waste through the development of an Integrated Waste Recycling System (IWRS). The IWRS will have the capability to handle unsorted municipal solid waste. It is designed around several pieces of equipment that are commercially available, and whose performance as stand-alone items of plant is well characterised. The innovation of the approach proposed is through the integration of the equipment and processes, to produce a stand-alone waste-processing system capable of dealing with a range of municipal solid wastes. The IWRS is designed to yield products that are marketable commodities, and which would add value to the waste feedstock.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Portal Range Monitoring in Mixed Ion Beam Surgery' (PROMISE), addressing dissemination and exploitation.

assistant: **Impact**

Half of the approximately 4 million annual cancer cases in Europe receive radiotherapy. While many cancer patients have benefitted from technical improvements in recent years, widespread diseases, such as pancreatic and lung cancer, still have dismally low cure rates, with median survival of less than 2 years. Carbon ion radiotherapy (CIRT) offers unprecedented precision in delivering tumour dose, and can be the much needed game changer for these patients. However, CIRT is vulnerable to uncertainties in patient positioning, anatomy changes and organ motion. The current clinical approach is to increase the high dose volume to ensure target coverage, counteracting the primary advantage of CIRT. Novel strategies for image guidance and beam range assessment are crucial to unlock the full potential of CIRT for the best possible patient care.PROMISE, for the first time, will produce mixed ion beams that enable concurrent treatment and image guidance. Carbon ions deliver the dose to the target while Helium ions, simultaneously accelerated to the same velocity, traverse the patient and monitor tumour location and beam range. PROMISE realizes true portal imaging, providing real-time information on the target anatomy as seen by the treatment beam. Coupled with innovative detectors, AI-based image recognition, and online dose reconstruction, this technique will enable to drastically reduce safety margins, and achieve the full potential of CIRT.The GSI accelerators are uniquely suited to develop the first mixed beam of Carbon and Helium, along with strategies for their cost-effective translation to existing and future clinical CIRT centres. The method will be validated experimentally in GSI’s former CIRT treatment room. Patient simulation studies will highlight clinical benefit and