RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quantifying ageing related cognitive decline and mild cognitive impairment' (COGDEC) under Horizon 2020.

assistant: **Objectives**

University of Ljubljana, located in a low R&I performing country, will partner with two internationally-leading organisations, the Medical University of Graz and KU Leuven, to expand the support and coordination capacity for national and European research in ageing-related decrease in brain functions leading to dementia. By 2025 more than 25% of European population will be over 60 years old, with people over 80 increasing most rapidly. Cognitive function declines with ageing, but unpredictably, remaining practically stable over time or progress rapidly to dementia, when a person loses the ability to live independently and enjoy a reasonable quality of life. Detection of the transition from a pattern of normal, ageing-related decline to a state associated with the beginning of mild cognitive impairment is crucial for providing long term effective medical support and a better quality of life to ageing people. Several advanced brain imaging methods are used to detect mild cognitive impairment. As no single method is optimal for the early detection, there is an urgent need for further improvement/refinement of these methods. Through this proposed project we will transfer current state-of the art methods in brain imaging, including magnetic resonance imaging, electroencephalography and positron emission tomography, from the two internationally-leading organisations to Ljubljana. This will be achieved by mentored training of early stage researchers and other researchers through workshops, summer schools, short-term on-site training and expert visits. With the two internationally-leading organisations, we will prepare joint collaborative grant proposals and PhD projects during the life time of the Twinning project. These will enable further development of advanced brain imagin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Single Photon source and detector based on novel materials for the detection of endocrine disruptors' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Water is one of the most important natural resources on earth and despite increasingly strict regulations, contamination of water that poses a health risk is still a major problem. In Europe, too, our drinking water is exposed to contaminants such as hormones, which even in extremely low concentrations can have effects on humans and animals and are therefore of interest for water monitoring in the context of nature conservation and also various branches of industry. Our goal in this project is to provide the layperson with a ready-to-use, compact, and robust spectrometer capable of measuring extremely low concentrations in the sub ng/L range. To this end, the GREENER project aims to develop new, environmentally friendly QDs capable of near-infrared absorption measurements at emission wavelengths as short as 2µm. These will be singulated by the DNA origami method and integrated into an LED layer stack to synthesize a novel kind of single-photon source. Combined with advanced single-photon detectors enabled by new detector materials that do not require expensive cryogenic coolers but rely on simple thermoelectric cooling, a setup for low-loss, low-noise and high-performance spectroscopy for the Vis to NIR range will be developed. The resulting biosensor will subsequently be evaluated for the detection of critical (endocrine disrupting) contaminants in water in fisheries and aquaponics and will enable end-users to monitor water safety and quality on-side without additional infrastructure or trained personnel.


**Keywords:** Quantum Dot, DNA origami, Single photon source, Single photon detector, photonics, biosensor, NIR spectroscopy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular evolution of functionally improved lipoxygenases for commercial exploitation' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The overall aim of this project is to carry out directed molecular evolution of naturally-occurring plant lipoxygenases in order to enhance their properties as biocatalysts in specific industrial processes and to gain more understanding of their structure and action.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification and functional assessment of genes specifically involved in hTERT regulation' (TELOMERASE) targeting Sixth Framework.

assistant: **Abstract**

Telomerase, a ribonucleoprotein complex responsible for the maintenance of telomeres, is significantly expressed in 90% of cancer cells and apparently absent in normal somatic cells. Expression of the catalytic protein component of this telomerase complex, hTERT (human Telomerase Reverse Transcriptase), seems to be the limiting factor for telomerase activity, and plays a fundamental role in cellular immortalisation. Moreover, increasing observations indicate that hTERT protein could also have an anti-apoptotic function, independently from its role in telomere elongation.The knowledge of the factors and mechanisms controlling hTERT expression would be highly significant to understand the telomerase re-activation process, a key step during immortalisation and onco-genesis in human cancers. At this date, few transcriptional factors are known to bind hTERT promoter but their actual contribution in telomerase regulation are not demonstrated. Moreover, published data from different laboratories indicate that important relevant transcription factors have not yet been identified.Thus, the factors and mechanisms controlling the hTERT transcription still remain to be elucidated during physiological processes. Using our unique cellular model, in which telomerase can be regulated by several means by a physiological agent, all-trans retinoic acid, we propose to use a cDNA microarray approach to identify and select genes that could be specifically involved in hTERT regulation. In continuation, we will use a functional genomics approach to assess their actual contribution in that process. Our experiments would contribute to a better understanding of hTERT regulation mechanisms, and could also be important for the identification of new target genes for anti-cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Uncovering the structure, dynamics and impacts of humid HEATwaves across AFRIca under present and future climate' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Heatwaves, the occurrence of extremely high temperature over a prolonged period, have been identified to cause death, reduce educational performance, weaken worker productivity, increase the risk of wildfire, and affect crop productivity. The occurrence of heatwaves has been increasing both in frequency, intensity and duration in the recent past climate and a robust increase in heatwave frequency, intensity and duration is projected in future climate scenarios. When accompanied by moist air, heatwaves can be even more lethal. During such humid heatwave (HHW) events, the physiological mechanism that allows the human body to cool down through transpiration is impaired. Previous regional research on heat stress focused mainly on Europe, South Asia, and the Persian Gulf, even though global studies also identify sub-Saharan Africa as a hotspot for heatwave extremes. Consequently, very little is known about humid heatwave occurrence and impacts in Africa due to the lack of dense meteorological networks and a consistent reporting framework. This project aims to uncover the structure, dynamics and impacts of HHW across Africa under present and future climate, and to translate this knowledge into actionable information for disaster management agencies. To achieve this objective, I will join the BCLIMATE research group under the Department of Hydrology and Hydraulic Engineering at the VUB. The host supervisor and the BCLIMATE research team have a world-leading reputation in climate extremes. Building on the tools of European Union's Copernicus Climate Change Service, the research outcomes will contribute to the forecasting of deadly heat stress across Africa and develop an early warning system to reduce HHW vulnerability. During my secondment at the UN office for Disaster Risk Re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'oneTap e-paper business card wearable gadget to create a real meeting LinkedIN equivalent'.

assistant: **Innovation**

Blendology has developed a mobile wearable tech that has already connected tens of 1000s of people from all over the world. We have created a innovative electronic badge that is at the root of all innovations by helping to foster the birth of new connections. oneTap is a re-useable and intelligent badge that instantly uploads information the attendee wishes to exchange if tapped to another badge. As a result, it acts as an ice-breaker, it erases any hierarchical barriers, it record contacts in real-time (secure mobile app access), it creates badges for event organisers, and it does not require external networks. Events using oneTap  will attract more attendees (better networking, both in terms of amount of connections made and of ease of correspondence after the event), and we help event organisers run current events and plan more strategically for future ones. We collect invaluable data (e.g. n. of people arrived/left and dwell time at particular locations, etc.), with endless potentials for analysis and monetisation. We have worked in 20 countries and received numerous requests for the licensing of our products globally. In EU alone, over 300M people/year attend events. A beta version of the oneTap badge has already generated €300k revenue. We also already have sales booked for 2016.Some goals of this project include creating a BP that defines a revised strategy, further development, and a market plan for: the expansions into new markets, big data analysis exploration, development of a new generation of our products (e.g. e-printed badges with optional speaker/delegate locator functionality, footfall traffic overview in the event, along with several new features). Most importantly, this grant will be instrumental to make sure we recalibrate all our strategies to ensur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Corticotropin Releasing Hormone (CRH) and Innate Immune responses to Gram negative Bacteria'.

assistant: **Innovation**

Several studies support the interaction between the endocrine and the immune systems during inflammation and have demonstrated the critical role of the hypothalamic-pituitary-adrenal (HPA) axis in this process.We have demonstrated proinflammatory effects of Corticotropin Releasing Hormone (CRH) in vivo and we have confirmed these findings by the compromised inflammatory responses of the Crh-deficient (Crh-/-) mice to a variety of stimuli.We have also shown reduced proinflammatory cytokine expression and lower NF-B activation in Crh-/- splenocytes exposed to lipopolysaccharide (LPS), and induction of NF-B activity by CRH in mouse thymocytes.Although the above findings indicate a pathway mediating the proinflammatory effects of CRH, the signalling pathways involved in the CRH-induced NF-B activation and up-regulation of proinflammatory cytokines remain elusive.Our working hypotheses are that the proinflammatory effects of CRH during Gram-negative infection are mediated by the I-B/NF-B and the MAP kinases systems and that CRH plays a role in the molecular regulation of the expression of Toll-like receptor (TLR)-4, that is critical in the transduction of the lipopolysaccharide (LPS) signalling inside the cells.Mouse and human macrophage cell lines, and primary cells from Crh-/- mice will be used to address the following:- Does CRH play a role in the regulation of TLR4 or its effects are exerted at the level of the adapter proteins and/or transcription factors activated by this receptor? What is the biological significance of the CRH-induced TLR4 regulation on the transcriptional activation of proinflammatory mediators of Gram negative infections?- What is the effect of Crh-deficiency on the molecular regulation of TLR4 expression? The overall significance of this proposal i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding the cytotoxicity of aberrantly folded proteins in neurodegeneration' (FoldTox), addressing dissemination and exploitation.

assistant: **Impact**

An advanced systems biology approach will be applied to understanding the molecular mechanisms of neurodegenerative cytotoxicity, triggered by aberrantly folded proteins. Three established cellular models of cytotoxicty of the misfolding-prone proteins synuclein,  TPD-43 and the Abeta peptide will be analyzed. In a discovery-phase, advanced proteome and  phosphoproteome-wide screens,coupled to biochemica ltools for monitoring cellular toxicity and protein aggregation,  will highlight biological processes sequentially affected by expression and aggregation of the misfolded proteins. The analysis will contribute to identifying triggering events and consequent phenomena, cellular responses that are specific to each  protein and those associated to generic stress responses. Quantitative phosphoproteomics measurements will unravel signaling states associated to the cytotoxic mechanisms. Transcriptomics analysis  will highlight protein changes that are not anticipated by gene expression data and suggest post-transcriptional regulation, possibly including protein aggregation phenomena.  Emerging hypotheses will be validated by targeted proteomics based on selected reaction monitoring and biochemical and genetic experiments on the disregulated pathways. A set of protein and phosphoprotein markers will be selected that characterize the onset of cytotoxicity at different biological modules and stages and an assay will be designed that measures them in a fast and reproducible manner. This fingerprinting will be used to screen a set of chemical and genetic modulators,  to characterize their mechanisms and strength. Overall, such  multi-level approach  will provide a global picture of the mechanisms that accompany the onset of proteinopathies and lead to neurodegenerative cell death
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HEAL-4WARD - doctoral network for Wound infection Advanced care and Rapid Diagnosis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The HEAL-4WARD doctoral network aims to train 11 Doctoral Candidates (DCs) across Europe to tackle the critical challenge of wound infections. By integrating cutting-edge nanomaterials, non-invasive label-free detection technologies, innovative additive manufacturing (3D-printing) and Artificial Intelligence models, we will prototype smart wound patches for personalized infection care and diagnosis. Our focus is on developing on-demand antimicrobial strategies that minimize antimicrobial resistance risks, coupled with advanced label-free diagnostics and imaging capabilities. This initiative brings together an academic and industrial multidisciplinary consortium of experts in (nano)material science, chemistry, additive manufacturing, biomedical engineering, molecular biology, microbiology, and clinical practice. Our goal is to translate and combine innovative technologies from the laboratory to prototype to clinical settings, enhancing patient outcomes and reducing the burden of infections on healthcare systems. DCs will receive comprehensive training across these different and cross-section fields, training them with skills and knowledge to tackle antimicrobial resistance in wound healing and at the same time to create groundbreaking solutions that position Europe at the forefront of personalized medical devices. Our focus on skin and soft tissue infections, including surgical site infections, acute burns, and chronic wounds such as diabetic foot ulcers, venous leg ulcers, and pressure sores, addresses the high prevalence of these conditions in hospitals and long-term care facilities. This emphasizes the urgent need for personalized treatment strategies to improve patient care and healthcare efficiency.


**Keywords:** Nanomaterials, Surface enhanced Raman Spectroscopy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a strategic master plan for the transformation of the traditional textile and clothing into a knowledge driven industrial sector by 2015' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

CLEVERTEX aims at developing a master plan and frame framework for future actions in research, education and technology transfer in the field of multi-functional intelligent textile materials In Europe for transforming the industry in a dynamic, innovative , knowledge driven competitive and sustainable sector by 2015. Multifunctional intelligent textiles are materials and systems, which react in an intelligent manner to external stimuli. An example could be a fabric that inflates ut cold temperature to keep the wearer warm, professional garment that change of colour to warn of biologic contamination, underclothes that send out an alarm to the medical assistant nearby when your vital parameters are warning or a carpet that detect flood, fire or burglar... The workprogramme will include: *Analysis of the available European know/ledge base for intelligent textiles;, *Investigation fnto the socio-economic framework of the textile and clothing sector;. *Foresight: Design of the Delphi study strategic analysis fo r identification of prioritised needs, for the transition to a knowledge based industry; *Gap Analysis and feasibility; *Road mapping; *Exploitation, dissemination and management. The partners in this consortium have clear complementary skills. The Indu strial partners are involved in the development, the production and marketing of multi-functional, intelligent textiles. The research institutes, of which 2 are academic institutions and 2 are national research institutes with close links to the industry, havs expert knowledge on multifunctional intelligent textiles. The European textile and clothing association involved in the project has developed skills and expertise in performing foresight studies in the area of information technologies for the textiles and clothi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nano Traction' in the context of a Horizon 2020 call.

assistant: **Objectives**

In this Marie Skłodowska-Curie Fellowship project entitled “Nano Traction” I will design a platform for the directed autonomous movement of nano- and microparticles. This will be achieved using a completely novel form of traction based on the dynamic covalent attachment of the particles to a surface.  Asymmetrically applied redox potentials will induce motion allowing the electrical control of nano- and microparticle motion and the creation of particles that autonomously move and seek out cells that are producing reactive oxygen species a key indicator of disease.  This Fellowship will be undertaken under the supervision of Prof. Molly Stevens in the Division of Biomaterials and Regenerative Medicine at the Karolinska Institute (KI), which has the world-leading expertise in functional nanomaterial synthesis, biomaterials engineering, cell biology and tissue engineering crucial to the objectives of this proposal. This ground-breaking new method of particle control at micro and nanometre length scales will have application in many areas including; precision actuation for nanorobotics and microfluidics and; the creation of cell seeking particles for biosensing and the targeted delivery of nanoparticle agents. It will not only initiate new research areas at the cutting edge of nano- and biomaterials science, but will help me to establish my own independent research career following the proposed Fellowship.