RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Heavy metal free waterborne anti corrosion coatings from intrincically conductive polymers' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Standardised procedures were selected and adopted prior to development of conductive primer systems. Because of economical and technical reasons, core shell dispersions have been fabricated using cores of latex particles that were covered with an ICP shell. Several factors have been investigated including; type and particle distribution of the latex; the type and concentration of ICP; the type of dopant and the pH during the redoping process. An interactive assessment was undertaken between coating development and electrochemical measurements. The electrochemical experiments consisted of laboratory studies, including monitoring of the Open Circuit Potential (OCP) and measurements of the polarization resistance.Electrochemical results showed the particle size of the latex system to be important. It appeared that latices with smaller particles accommodate larger amounts of ICP at the surface. This is very important since it is expected that the effects of corrosion inhibition are proportional to the amount of ICP added to the system. In addition, latices with small particle sizes show better film formation than latices with large particles because of larger capillary forces during drying. Since the encapsulating ICP layer hinders film formation it is expected that the larger capillary forces will help to overcome this barrier.Out of several latex systems an optimal system, with good film formation properties and corrosion protection properties, was selected for further research.From the prototype primers developed based on this formulation, different (solvent and water based) binders have been developed and investigated by electrochemical tests and corrosion test programs with two different cyclic exposure environments; humidity/dry and salt-spray/dry. After the cyclic ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Elucidating molecular principles of RNA phage-host interaction' in the context of a Horizon Europe call.

assistant: **Objectives**

Bacterial viruses called phages are highly diverse predators with multifaceted life cycles. Recent major breakthroughs in phage biology brought phages back into the spotlight, highlighting their tremendous potential in basic and applied research. For instance, bacterial immune systems were shown to be the origin of human innate immune systems and there was significant progress in developing phages into therapeutics to treat multidrug-resistant bacterial infections.However, this recent renaissance of phage research neglected the study of phages with RNA genomes, which are a historically understudied group of phages with a fundamentally different biology from that of phages with DNA genomes. Consequently, the current developments in phage biology left the potential of RNA phages untapped. RNA phages rely on unique regulatory mechanisms during their replication cycles while requiring their hosts to employ specific immune systems to combat the infection. These unique phage and host mechanisms must be highly specific to guarantee efficient phage replication and avoid auto-immunity, respectively. I posit that understanding these processes is a prerequisite to utilize RNA phages as therapeutic agents and bears the potential to discover new biotechnological tools. In RIBO-PHAGE, I therefore aim to elucidate the unique lifestyle of RNA phages at the molecular level. Specifically, I will1) Decipher how RNA phages regulate their replication for efficient propagation.2) Elucidate the host factors RNA phages hijack during replication.3) Determine how bacteria defend themselves against RNA phage infection.Building on my extensive background in RNA and phage biology, I will combine molecular biology and biochemistry methods with global high-throughput techniques using RNA phages of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Advanced workshop: sea urchin aquaculture'.

assistant: **Objectives**

Sea urchin aquaculture has been practised in several countries to compensate for the decline of natural stock and to improve the production, which has been proved to be essential and effective. Natural stock of sea urchins in the Community is declining due to over-catching and environmental changes. The proposal aims to hold an advanced workshop for sea urchin aquaculture based on scientific natural stock management. Specialists will be invited as lecturers for the workshop from Europe, USA and Japan where advanced aquaculture for sea urchins are practised.The workshop will offer participants:(i) theoretical and practical lessons for the understanding of biological background and resource management of sea urchin stock,(ii) acquisition of advanced techniques in sea urchin aquaculture.The proposal includes the publication of a handbook to support further development of sea urchin aquaculture in the Community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ecology from Farm to Fork Of microbial drug Resistance and Transmission' (EFFORT), addressing dissemination and exploitation.

assistant: **Impact**

EFFORT studies the complex epidemiology and ecology of antimicrobial resistance and the interactions between bacterial communities, commensals and pathogens in animals, the food chain and the environment.This will be conducted by a combination of epidemiological and ecological studies using newly developed molecular and bio-informatics technologies. EFFORT will include an exposure assessment of humans from animal/environmental sources. The ecological studies on isolates will be verified by in vitro and in vivo studies. Moreover, real-life intervention studies will be conducted aiming at reducing the use of antimicrobials in veterinary practice. Focus will be on understanding the eco-epidemiology of antimicrobial resistance from animal origin and based on this, predicting and limiting the future evolution and exposure to humans of the most clinically important resistance by synthesising different sources of information in our prediction models. Through its results, the EFFORT research will provide scientific evidence and high quality data that will inform decision makers, the scientific community and other stakeholders about the consequences of AMR in the food chain, in relation to animal health and welfare, food safety and economic aspects. These results can be used to support political decisions and to prioritize risk management options along the food chain. The EFFORT consortium is made up of 20 partners from 10 European countries: Belgium, Bulgaria, Denmark, France, Germany, Italy, the Netherlands, Poland, Spain and Switzerland.The senior investigators leading this proposal bring together complementary strengths antimicrobial resistance, food safety, epidemiology of food borne pathogens and risk modelling, environmental epidemiology and microbial ecology, exposure as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'GENETICS BASIS OF THE NONHOST RESISTANCE TO POWDERY MILDEWS AND RUSTS IN BARLEY'.

assistant: **Innovation**

Full nonhost resistance can be defined as immunity displayed by an entire plant species against all genotypes of a plant pathogen. The genetic basis of (non)host-status of plants is hard to study, since identification of the responsible genes would require interspecific crosses that suffer from sterility and abnormal segregation.  There are some plant/potential pathogen combinations where only 10% or less of the accessions are at most moderately susceptible. These may be regarded as marginal host or near-nonhost, and can provide insights into the genes that determine if a plant species is a host or a nonhost to a would-be pathogen, and to investigate the genetics of the host-status to specialized pathogens.Barley (Hordeum vulgare) is an example of a near-nonhost to several rusts (Puccinia) and powdery mildews (Blumeria graminis) of cereals and grasses. The research group of Dr. RE Niks has accumulated susceptibility to different heterologous rusts and powdery mildews in several lines. These lines and fully resistant accessions have been used to develop mapping populations which are the starting point material of the present study. In particular, the project aims to enhance the knowledge on the genetic basis of the resistance at the species level (nonhost resistance) to rusts and powdery mildews in barley. These systems are being used as models to gain more insight in the nonhost resistance phenomenon to understand its genetic basis. This research is unique in its approach and will add new scientific insights, complementary to the nonhost research elsewhere. These scientific advances are of great interest because they allow understanding which genes are involved in natural variation between plant species in (non) host status to specialized biotroph pathogens. This knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel Process Windows - Boosted Micro Process Technology' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Novel Process Windows (NPW) is an entirely new way of process design to boost micro process technology for the production of high-added value fine chemicals. Such process intensification demands for microstructured reactors with their excellent capabilities on mass and heat transfer and short residence times with prime constructional and functional features. This proposal is truly comprehensive and holistic as it includes four projects with different NPW facets; starting from a molecular-mechanistic- (New Chemical Trans¬formations) and kinetic-scale (High-Temperature / Pressure Processing) via the scale of reaction environment (Solvent-free Operation and Tuneable / Reactive Solvents) up to a process scale (Process Simplification and Integration). These four individual measures are bundled and directed by a generic project for cross-cutting insight, evaluation through cost and life-cycle analysis, and transfer to a large number of reactions.High-p,T processing will enable for the Claisen rearrangement to shrink reaction times by orders of magnitude and to increase space-time yields consequently. Substantial selectivity increases are targeted for this reaction and the hydroformylation. The latter reaction will make use of tuneable solvents and near-critical water processing. As new chemical transformations with  process simplification and integration, the direct oxidation of cyclohexene to adipic acid as one-step synthesis and the copper-catalysed triazole Click Chemistry as one-flow multi-step synthesis will be tested.These new and challenging processing technologies provide highly promising perspectives for future ‘green’ chemical factories to boost sustainability, covering the whole manufacturing chain in one system and providing a multi-purpose infrastructure.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable surface protection by glass-like hybrid and biomaterials coatings' (BIO-SUSHY), addressing dissemination and exploitation.

assistant: **Impact**

To meet EU key strategic orientations for the development of digital, enabling, and emerging technologies, sectors and value chains, the project BIO-SUSHY proposes a complete operating framework for the development of innovative repellent organic and hybrid coatings to challenge widespread yet polluting polyfluorinated alkyl substances. These coatings aiming both hydrophobic and oleophobic properties will be obtained from acknowledged processing technologies, i.e., bio-based thermoplastic powder and hybrid sol-gel. Advanced functionalization will be ensured by bio-based additives added to formulations. Coatings will be applied on various substrates for validation of applications at pre-industrial scale in different domains such as the textile, glass cosmetic and food packaging. Material selection, formulation and coating process will cope with a tailored regulating Safe and Sustainable by Design (SSbD) strategy which evaluating criteria will encompass the risk toxicity of materials and hazardous leachate as well as life cycle assessment to determine economic and environmental impacts along the value chains. This SSbD strategy will be powered by physics based and data driven modelling tools for predicting both repellent properties of coating surfaces and leaching mechanisms of composites. Along with experimental measurements, modelling activity will serve a larger computational tool including all data collection and curation in a harmonized and annotated infrastructure for training and provision towards existing data repositories and marketplaces. This tool will complete a wider dissemination and valorisation strategy including not only scientific and economic aspects, but also to pave the way towards certification of materials and products for their introduction in pre-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Next-generation fungicides for crop protection based on artificial small RNAs derived from viral vectors'.

assistant: **Concept**

Plants are threatened by a plethora of pathogens, with fungi accounting for important crop and post-harvest losses worldwide. Despite widespread spraying of fungicides, losses keep rising in the current warming world and the increasing use of chemical (and toxic) fungicides favours the emergence of resistant fungi strains. Hence, there is an urgent need to develop a new generation of highly efficient and environmental-friendly fungicides for securing present and future food availability.Classic RNA interference (RNAi) tools based on double-stranded RNA have been used for inducing antifungal resistance in plants, despite their lack of high specificity. More modern and highly specific RNAi tools are based on artificial small RNAs (art-sRNAs). Art-sRNA tools have been optimized mainly for high efficacy and transgenic use but are not well adapted for GMO-free application and have not been used yet for inducing antifungal resistance in plants. FunSynVIGS seeks to develop a novel, GMO-free RNAi technology consisting in systemic, viral vector-based fungicides expressing art-sRNAs for plant immunization against pathogenic fungi. The specific objectives are:(1) The development and optimization of viral vector-based fungicides expressing art-sRNAs against Botrytis cinerea, the causal agent of the gray mold disease, in the model plant species Nicotiana benthamiana.(2) The application of viral vector-based fungicides for immunizing tomato plants against B. cinerea.Successful completion of these objectives will provide a novel class of mobile RNAi-based fungicides for inducing highly efficient antifungal resistance in crops.


**Keywords:** RNAi ,  Artificial small RNAs ,  Pathogenic Fungi ,  Next-Generation Fungicides ,  Plant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EFFECTS OF AFFORESTATION OF AGRICULTURAL LAND ON HEAVY METAL MOBILITY IN SOIL' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The overall aim of the project is to elaborate guidelines for afforestation of set aside land to counteract any harmful environmental effects on the soil water system.The aim involves four operational subaims.- Quantify contents and binding characteristics of heavy metals in relation to pH, organic matter and dissolved organic matter in afforested systems- Focus on pH, organic matter (OM) and dissolved organic matter (DOC) as factor influencing the soil at afforestation and quantify how these factors are changed by afforestation under certain site conditions and management strategies- Model development of soils subjected to afforestation at various scenarios of management, climate change etc.- Develop guidelines for management of afforestation projects (tree species, soils, amendments) and for policy decisions on land useThe project is consistent with the objectives of work-programme area 4emphasising the multifunctional management of forests with focus on the possibility to reach a sustainable management of afforested systems with a minimum of unwanted impacts on neighbouring ecosystems.In Europe today about 8.5 million hectares of agricultural land will be available for alternative land use. During the agricultural land use heavy metals have been added to the soils through fertilizers, lime etc and kept immobile in the soil due to a high pH. At a shift of land use, conditions that favour mobilization of the heavy metals may occur (lower pH, changes in organic matter etc.) The benefits of this project will be guidelines for afforestation projects of set aside land and for policy decisions on land use.The project is a joint programme of countries in northern Europe that are submitted to a great change of land use and that have soils sensitive of acidification, water sta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mechanisms of selective transmission of epigenetic marks through the male germ line' (EpiRetention).

assistant: **Concept**

During spermatogenesis, germ cells go through important chromatin remodelling steps, the most striking being the replacement of histones by protamines, which promotes the compaction of the paternal genome in the sperm . However, a proportion of nucleosomes, ~1% in mice and ~15% in humans, are retained following protamine incorporation. It is thought that those remaining histones might play a role in the development process after fertilization possibly by transmitting epigenetic information to the progeny.Investigating the process of histone/protamine exchange has been extremely challenging because of the difficulty to isolate and manipulate germ cells at different stages of their development in vivo. Recently, an in vitro system has been established to produce mouse embryonic stem cell (ESC)-derived male haploid gametes . We propose to use this remarkable system for a comprehensive genomics approach to get an understanding of the chromatin dynamics and functionally test the requirement of candidate proteins involved in the histone/protamine exchange process. This represents a novel approach to investigate the pathways responsible for histone eviction and protamine incorporation. Furthermore, we will determine how nucleosomes are retained at specific genomic regions in mature sperm and if they are involved in the transmission of epigenetic traits to the progeny.  Such innovative study relying on advanced in vitro differentiation methods together with genome and chromatin editing techniques aim to bring valuable insight regarding germ cell development and determine whether stochastic or environment-directed changes in the nucleosome profile can be epigenetically propagated to the embryo via the sperm and affect the fitness of the offspring.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Development of a cost-effective adjustable damping sole based on magneto-rheological fluids to provide diabetics with a customizable product-service which reduces foot stress and diseases'.

assistant: **Concept**

Foot diseases are indeed recognized as a wide societal problem and the large majority of people affected are women. This problem is particularly relevant if we consider that 25% of the diabetic population suffer from feet diseases and alterations. Our project aims at developing a novel ergonomie, comfortable, shock-absorbing and highly recyclable sole able to real time auto-shape itself based on magneto-rheological (MR) fluids.Our idea is to instantaneously and cost-effectively vary the stiffness and shape according to the different pressure produced while walking or running onto the different areas of the sole, through the application of a low-power micro-controller powered by embedded piezoelectric foils.