RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New Nuclear Medicine Imaging Radiotracer 64Cu(II) for diagnosing Hypoxia Conditions Based on the Cellular Copper Cycle' (II).

assistant: **Concept**

Imaging of hypoxia is important in many disease states in oncology, cardiology, and neurology. Hypoxia is a common condition encountered within the tumour microenvironment that drives proliferation, angiogenesis, and resistance to therapy. Despite on-going efforts to identify hypoxia, until now there is no clinically approved imaging biomarker, due to both low tumour uptake, and a low signal to background (S/B) ratio that affects the imaging quality. Nuclear Medicine is using labelled radio-isotopes for PET/CT and SPECT imaging. These radio-tracers diagnose the metabolic processes in the body. Among these tracers, 18F-FDG is the most routinely used as a marker of glucose metabolism. However, not all tumours consume glucose, and glucose consumption is not specific only for malignant tumours, which limits its application. Copper is a nutritional metal, recently examined as a radiotracer for hypoxia, owing to its to the oxidising environment. Clinical and in-vivo studies on various 64Cu(II)-PET radiotracers resulted in controversial reports on the specificity of the current tracers for hypoxia imaging due to non-selective bio-distribution & low S/B ratio. This multidisciplinary proposal focuses on the discovery of comprehensive signal pathways of the cellular copper cycle using advanced biophysical methods and a proprietary design of 64Cu(II) radiotracer. This radiotracer will be incorporated in the cellular copper cycle, and will enable to selectively target the oxidising environment in tumours. The design of the new radiotracer is based on systematic structural & functional mapping of the copper binding sites to the various copper proteins and the visualisation of the transfer mechanism. This new copper tracer should increase the selectivity of tumour uptake, stability,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The genetic dissection of herpes simplex encephalitis (HSE) in children'.

assistant: **Objectives**

Herpes simplex encephalitis (HSE) is a rare disease affecting young children as well as adults due to primary infection with herpes simplex virus-1 (HSV-1). HSV-1 is a nearly ubiquitous virus commonly infecting humans however most do not develop HSE, suggesting that these children possess an underlying genetic susceptibility to HSV-1. In addition, familial forms of HSE have been described, and in our HSE epidemiological study a relatively high incidence of consanguinity was found among HSE patients supporting the notion of a genetic contribution to disease manifestation. Notably, these patients are otherwise healthy and able to mount a normal adaptive immune response to HSV-1, pointing to the likelihood that they harbor an unidentified form of primary immunodeficiency disease affecting their innate immune system. We have recently identified the first two genetic etiologies UNC93B and TLR3 deficiencies in HSE patients validating our hypothesis. Here we propose to use a candidate gene approach to identify other gene(s) involved in HSE by cellular phenotyping and physical mapping. The cellular phenotyping will focus on one of the major components of antiviral innate immunity, namely, the production of and response to interferon-α/β (IFN-α/β). Patients with mutations in UNC93B and TLR3 show reduced IFN production after viral and double-stranded RNA stimulation, revealing this specific UNC93B-TLR3-IFN pathway as relevant to HSE immunity. Hence, HSE patients will be screened for IFN production in response to HSV-1 and Toll-like receptor agonists, and the causative genes identified following a candidate gene approach. In parallel, physical mapping has been initiated following the results of a genome scan of consanguineous families with HSE. The identification of genes involved
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Origins of Referential Communication' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

This project brings together scientific teams working from a variety of perspectives on one of the defining features of human cognition -referential communication. This ability was once thought to be uniquely human. But recent research suggests that othe r species, including not only primates but also more distant evolutionary relations, have evolved referential signals. Our starting point is that human referential communication should be conceived of not as one ability supported by a single mechanism, b ut as a complex function that results from the integration of diverse mechanisms that may have different evolutionary origins. Understanding referentiality requires an analysis of its component skills and how they can be articulated into systems of varyin g complexity. This can be best achieved through a crossdisciplinary comparative evolutionary approach. Our aim is to implement such an approach tracking the evolutionary origins of some of the key components of referentiality and the diverse ways in whic h they are realised and combined by evolution. We propose a set of empirical projects aimed at gathering innovative evidence on referential signals in various species of primates (including humans) and non-primates. These combine observational and experim ental studies in the wild and in captivity exploring the semantic flexibility of referential calls in monkeys, dolphins, and parrots, the use of referential calls and referential gestures in great apes and canids, and their combination with skills such as Theory of mind to govern their strategic use. Our proposal unifies concepts and methods, and applies similar tests across species to guarantee the comparability of data. The empirical studies are integrated with two overarching theoretical projects aim ed at reassess
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Breaking new frontiers in the use of NanoSIMS as an analytical tool for inferring the isotopic and critical metal geochemistry of clay-rich geological materials' (TRANSITION) targeting Horizon Europe.

assistant: **Abstract**

In line with the European Union strategies, the TRANSITION project aims to advance the scientific knowledge of past climates and evaluate critical metal resources. The first objective of the project is to reconstruct palaeoclimatic conditions by analysing the oxygen and hydrogen isotopic composition of clay minerals and oxides in Lower Cretaceous aluminium-rich rocks (laterites and bauxites) from NE Spain. Current limitations in isotopic analysis due to the nanometric scale of these minerals will be overcoming by developing an advanced analytical procedure using NanoSIMS (nanoscale secondary ion mass spectrometry), thus enhancing Europe's capabilities in this area. TRANSITION also aligns with the European Commission's 2023 recognition of certain metals as critical for the energy transition, since laterites, bauxites, and red muds (bauxite by-products after industrial processing) are valuable sources of such metals. The second objective of the project is the NanoSIMS high-resolution grain-scale mapping of the minerals containing critical metals in laterites, bauxites and red muds , thereby determining the sub-micron distribution and specific location of these metals within these materials.  The successful implementation of the project, based on the expertise in geological and analytical chemistry of the applicant and supervisor, respectively, will contribute to the research prowess of Europe. The projects outcome will be of global significance, inspiring geoscientists worldwide to use NanoSIMS and expand our understanding of past climatic conditions. TRANSITION will also contribute to complementing the Lower Cretaceous paleoclimatic record in Western Europe and will report fundamental data for the future design of critical metals extraction strategies, allowing to consid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Technology for Wafer-scale Carbon Nanotube Applications' in the context of a Seventh Framework call.

assistant: **Objectives**

Carbon nanotubes are materials with a set of unique electrical, mechanical, surface and thermal properties. Yet their adoption in mainstream applications has been limited by mass production and device integration. This project develops the first 300mm wafer-scale equipment for production of carbon nanotubes on surfaces. The project will cover the design, engineering, process control, quality assurance, qualification and process development. It will develop applications in cathodes for time resolved X-ray sources for X-ray tomography, cathodes for high power microwave amplifiers, interconnects for VLSI, thermal management surfaces, low stiction surfaces for micro-fluidic channels and filters, wafer scale fabrication of spin valve devices, and sensor surfaces for integrated sensors on CMOS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Investigation of novel routes to polyene structures'.

assistant: **Innovation**

Conjugated polymers, either olefinic or aromatic, have proven to be electrically conductive after doping. Due to their intractability, the doping process typically involves the treatment of an insoluble material with a solution containing an oxidizing or reducing agent, which then creates cations or anions that are incorporated in the Pi-system, via a surface reaction. Nevertheless, doped polyacetylene shows electrical conductivities that are similar to those of metals. The synthesis leading to the structurally most regular polyacetylene involves a ring-opening metathesis reaction (ROMP) to a precursor polymer which forms polyacetylene in an extrusion reaction. One idea in this regard is to make a polyacetylene accessible, which would automatically dope itself upon formation. This project is aimed at studying the ROMP of substituted bicyclo(6.1.0)nona- 2,4,6-triene (1). Precursor polymer 2 is anticipated to be soluble and therefor processible; it should furnish a polyacetylene carrying a positive charge every ninth carbon atom via the cyclopropyl/allyl isomerization, thus cationic species will be created not at the surface as in common doping processes but in the bulk of the material as a whole.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Mobile Empowerment for the Socio-Economic Development in South Africa'.

assistant: **Innovation**

Mobile empowerment based on mobile technologies allows the development and implemen-tation of new business models and new business opportunities targeting micro enterprises and their customers in developing countries like South Africa.The goal of MOSAIC 2B is to develop and test a new framework that uses cloud-based ap-plications, innovative low-cost internet delivery mechanisms (delay tolerant networks and opportunistic communications) and affordable mobile technologies to unlock new mobile business opportunities, especially in rural villages. A consortium of European and South African partners builds upon the use case of mobile digital cinemas to run real life experiments demonstrating and evaluating the technological and economic viability of according innovations.In essence MOSAIC 2B delivers a combination of mobile digital cinemas for edutainment (educational content and entertainment), mobile business and consumer services as well as visual analytics and interactive tools to obtain real-time knowledge of on-going processes,  to support decision making, and to increase business opportunities. Ultimately the business case of South African micro entrepreneurs delivering edutainment to rural consumers serves as a showcase for broad based economic activities at the bottom of the economic pyramid in the developing world. Adapted innovative services at affordable cost offer sustainable access to new markets on a global scale to the benefit of underserviced populations, local and European service providers.<br/>
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sculpting cerebellar activity across timescales' (SCULPTABELLUM).

assistant: **Concept**

Long-term memories are consolidated over time, progressively becoming more stable and resistant to interference. The consolidation of motor memories is particularly robust – so much so that we use the term “like riding a bike” to describe things that we never forget. And yet, compared to declarative memory systems, relatively little is known about the neural mechanisms through which motor memories are consolidated in the brain. Several forms of motor learning require the cerebellum, a brain area that is often thought of as a machine-like input-output device in which sensory inputs are combined with state estimation to compute motor commands. However, recent work has emphasized the extent to which cerebellar circuit function is influenced by external features, such as the animal's behavioral state, or the statistics of the environment. Moreover, activity that occurs offline – between experimental sessions and even between individual trials, within sessions – can be crucial for cerebellar function. Here, we will investigate how cerebellar activity is sculpted over time, not only during the execution of cerebellum-dependent behaviors themselves, but also during offline ‘rest’ periods, and across stages of learning, to consolidate recent memories and update the system to allow it to learn new things. We will use temporally precise, cell-type-specific neural circuit manipulations and recordings to ask: 1. What are the mechanisms through which offline cerebellar activity contributes to memory consolidation? 2. What roles does memory consolidation play in long-term motor adaptation and metalearning, or ‘learning how to learn?’ 3. How do climbing fiber inputs to the cerebellum contribute to determining what is learned? Together, these experiments will reveal how cerebellar acti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Heidelberg 2000: Field theories on the light-cone and Hadron Phenomenology'.

assistant: **Objectives**

The goal of HD 2000 is to facilitate the presentation and discussion of new methods in theoretical physics, specific to light-cone quantisation and their confrontation with other more established treatments of nuclear and particle physics. The event is organised in the framework of an established bi-annual international series on light-cone quantisation. This series originated in Heidelberg in 1991, and has now grown with the progress and interest in the field. Hd 2000 presents an opportunity, through invited talks, topical presentations and informal discussion, to objectively assess the recent progress and highlight directions for future work in a field on the brink of major scientific applications. It will involve not only senior scientists who have pioneered the field, but younger ones who are now taking up the challenge, and senior scientists from closely related field who will provide context for their work.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00031-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Students Achieving Valuable Energy Savings 2' under Horizon 2020.

assistant: **Concept**

Students Achieving Valuable Energy Savings 2 (SAVES2) will catalyse sustainable energy behaviours among over 219,000 university students in seven countries to help them reduce their exposure to fuel poverty. It incorporates two strands that engage with students living in university accommodation (Student Switch Off) and in the private-rented sector (SAVES).Student Switch Off is an energy-saving competition that will reach 38,000 students living in 144 dormitories in 14 universities of the partner countries in each academic year from 2017/18 to 2019/20. By identifying and training student ambassadors in each dormitory, and by motivating the ambassadors to encourage their peers to save energy, we will create a race between students in dormitories, each competing to save the most energy and win prizes. It will tap into online student communities through social media, using engaging digital communications (quizzes, photo competitions) to raise awareness of how students can save energy in a fun way. The centrepiece of each competition will be an energy dashboard that updates students in near-real time on the performance and position of their dormitory in the competition – providing feedback and encouraging further action.The private-rented sector engagement work (SAVES) will reach over 100,000 students when they are looking for, moving into and living in the private-rented sector. It will enable students to make better informed decisions at the point at which they are selecting a rental property – thereby routing purchase decisions towards higher efficiency properties. SAVES2 will incorporate national-level partnerships with smart meter delivery agencies to develop student-focused communication materials highlighting the benefits of smart meters. It will provide ongoing advi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Macrophage proliferation and ontogeny in murine models of atherosclerosis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Atherosclerosis is a slowly progressing inflammatory disease that underlies some of the most common causes of death in western society. The central role of macrophages throughout its pathogenesis makes this cell an eminent target for therapeutic intervention. Recent studies have subverted the classical view that atherosclerotic plaque macrophages mainly originate from recruited circulating monocytes, launching the new notion that macrophages could also be derived from clonal expansion of resident macrophages or even trans-differentiated vascular smooth muscle cells. The relative importance of these mechanisms to the pathogenesis remains however unclear, due to a lack of adequate animal models that allow assessing this question.In this project, I introduce a recently developed fate mapping model, the LysMCre-Ubow+/+ mouse, into the atherosclerosis field to conclusively identify regions within the plaque that were formed through local proliferation rather than monocyte recruitment. Apart from quantifying its relative contribution to plaque growth during disease progression and regression, I will furthermore characterize the localization, transcriptional activity and the lipidic makeup of these proliferated cells versus invaded monocytes. In a second part of this project, I will deploy adoptive bone marrow transfers from WT to Ubow mice and vice versa as a model to quantify intraplaque myeloid versus stromal-cell derived macrophages. I will compare proliferative capacity, phenotype, transcriptomics and lipidomics of these two subsets and link this information to their functionality.With this strategy I will be the first to reveal the impact of the three macrophage accumulation mechanisms throughout the disease course, to couple this to their function and to exploit this kn