RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Elucidating transcriptional rewiring on hematological malignancies via computational methods'.

assistant: **Objectives**

Genes and their corresponding pathways form networks that regulate various cellular functions that are critical in tumor development. These networks, coined Gene Regulatory Networks (GRNs), define the regulatory relationships among genes and provide a concise representation of the transcriptional regulatory landscape of the cell. Further, different phenotypes can lead to activation of different functional pathways by different global rewiring of the underlying GRNs. To uncover such transcriptional rewiring, in this project I will further advance and optimize a recent efficient computational method developed by myself, coined LINKER,  aiming at uncovering GRNs from RNAseq data; and given those networks, develop efficient differential network analysis methods that will shed light into the regulatory rewiring associated with phenotype. As one of the key goals of this proposal is the translation of computational methods to advance clinical cancer knowledge, I will work with the hosting group to apply LINKER to uncover the transcriptional rewiring associated to hematological malignancies. Specifically, I will apply LINKER in a stepwise model first on available RNA-seq data from multiple myeloma and acute myeloblastic leukemia, and second to primary data from patients with these diseases provided by the hosting supervisor. Rewired GRNs between MM and normal BM plasma cells and between leukemic blast and normal hematopoietic progenitor cells, potentially implicated in the pathogenesis of the disease, will be functionally validated by state of the art gain and loss of function technologies (CRISPR/cas9). As data provided by the host institution includes clinical follow up from patients we will also examine the prognostic value of our identified GRN.  I envision that LINKER will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The physics an applications of advanced semiconductor optical emitters' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The objectives of this project are to research the physics and to develop some applications of advanced semiconductor optical emitters. Physics research will emphasise improving fundamental understanding of underlying mechanisms and processes. The proposed emitters and studies include: - High speed lasers; what is the limit? - Self-pulsing lasers; what is the mechanism? - Micro-cavity devices; what is the cavity process? - ll-Vl devices; material and operating issues New applications research will use devices already developed or under development such as: - DFB lasers; developed for telecommunications but now being applied to gas detection - Self-pulsing lasers; developed for CD memory but now useful for optical synchronisation - Vertical cavity semiconductor lasers; currently being developed for optical interconnection - Short wavelength ll-Vl lasers; being developed for optical memory but with potential to be applied to displays, vision or sensing - Laser-like LEDs; possible application to displays, sensing, and telecommunications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An integrated high-throughput human cell and Drosophila screening platform for the expedited discovery of anti-ageing compounds' (AgePhagy) targeting Horizon 2020.

assistant: **Abstract**

The steeply increasing ageing population, and accompanying rise of age-related diseases will soon have profound societal and economic effects, making ageing research increasingly important and outcome of this grant impactful. Our most promising way to improve health in the elderly is by replicating decades of genetic finding in model organisms of healthy long-lived mutants to pharmacological approaches. This will enable transition of these findings to clinical trials. In the CancerPhagy project, we showed that genetic upregulation of autophagy, major cellular degradation pathway, increased lifespan, which we aim to mimic by pharmacological treatment.  To this end, we developed the CellAge epigenetic clock, which is based on DNA methylation and which is the first clock that accurately detects subtle ageing changes in human primary cells in vitro upon a short anti-ageing drugs treatment, as shown using rapamycin and trametinib. This differentiates our clock from other available epigenetic clocks which are designed to accurately determine human age in years. By connecting the CellAge clock to autophagy drug library we will test the commercial viability of our anti-ageing drug assessment platform. To further validate our CellAge clock as a robust human ageing biomarker, we will combine its outputs with longevity assays in vivo in Drosophila. The final outcome will be an innovative and accelerated discovery platform for sought after anti-ageing/geroprotector drugs, which we will in this first instance test autophagy modifier drugs. Throughout the project we will closely collaborate with our industrial collaborator, GSK and UCL Business, which will assure we maximise the potential of our platform. Our ultimate goal is to uncover novel autophagy modifiers with anti-ageing prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Single-atom decorated 2D catalysts for power-to-X conversion and sustainable future'.

assistant: **Concept**

High efficient Power-to-X technologies such as hydrogen production by water splitting, the electrocatalytic reduction reaction of carbon dioxide to fuels, and nitrogen reduction to ammonia are the cornerstones for building sustainable future energy and economy. P2X technologies are a direct tool for achieving carbon neutrality and reducing the negative effects of anthropogenic climate change, as well as, dramatically reducing the role of fossil fuels in energy and industry, making it impossible to use the fossil fuels supply as an instrument of political pressure. The Proposed project is aimed at the development and complex study of the electro- and photo-electro active materials based on single-atom-modified 2D flakes of MXenes and MBenes, aimed at significant improvement of the energy efficiency of Power-to-X technologies. Optimization of the composition and structure of catalytic sites, including the simultaneous decoration of material by two or several atoms of different elements, controlled by electrochemical atomic-force spectroscopy will be used for the preparation of efficient catalytic materials with outstanding properties. Novel methods of decorating 2D materials by laser and microwave exposure, as well as, general patterns of controlling the catalytic MXenes and MBenes activity by SA (SA ensemble) structure will be also developed.


**Keywords:** MXene, MBene, Single-atom site, Carbon dioxide reduction reaction, Nitrogen reduction reaction, Oxygen reduction reaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'GENEtic VAccine technology and the coronavirus CRISIS: exploring socio-technical change and responsible innovation (GENEVACRISIS)'.

assistant: **Innovation**

The coronavirus pandemic has disrupted our ways of living across the globe. This research project will use social science and humanities approaches to analyse the enabling role of the coronavirus crisis in the development and (potential) deployment of emerging genetic vaccine technology, and associated transformations in social values and scientific research practices. Although traditional routes are being utilised to develop vaccine candidates, the pandemic has thrown open doors for the introduction of the state of the art genetic vaccines as an emergency response, e.g. Moderna Inc.’s vaccine candidate ‘mRNA-1273’. The underlying mRNA technology presents a completely new yet unproven therapeutic modality, which scientists believe has the potential to disrupt the drug development domain. In practice, only a few gene therapy approaches have received drug approval, and these are mainly aimed at treating rare hereditary conditions. In contrast, genetic vaccines would potentially be administered to the general population, both healthy and affected. They would hence normalise the mRNA medicine platforms. However, the state of the art mRNA therapeutics in general and genetic vaccine technology in particular is yet to undergo serious scrutiny and analysis from a social science perspective, a gap and original research problem that this project aims to address. The project will examine narratives around the Covid-19 pandemic, and through interviews and focus group discussions with scientists, policymakers, and science communicators will explore its enabling role in the introduction of genetic vaccine technology. Furthermore, it will analyse the ways in which these developments might shift social values and research practices. The research outcomes will provide key insights to po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'System engineering expertise dedicated to smes' (SEEDS), addressing dissemination and exploitation.

assistant: **Impact**

SEEDS: System Engineering Expertise Dedicated to SMEs, will be a research project dealing with the adaptation to SMEs of the aeronautical system engineering methodologies. The principal objectives of SEEDS as regards the industrial and economic impacts are:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Novel methods of synchronous modulation for the medium-power and high-power converters', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The main objective of the project is the development, dissemination, adaptation and implementation of novel alternative methods (methodology) of pulsewidth modulation (PWM) to perspective topologies of the medium-power and high-power electronic converters, which are an important control part of adjustable speed electric drives.These new methods will allow providing:a) Synchronization of the output voltage waveforms of the converters, with improvement of its spectral characteristics;b) Increase of computational speed of control algorithms, andc) Minimization of the common-mode voltages in systems to prevent bearing currents, and thus increasing the bearing reliability and the life span.For the two-year duration of the project, the following major tasks will be completed:(1) Dissemination of the method of direct synchronized PWM to three-level converters with a full set of voltage space vectors, to the neutral-point-clamped inverters with the four- and five-level output voltage, to cascaded converters, t o the six-phase induction motor drive systems;(2) Detailed modeling and simulation of processes in systems with synchronized algorithms of PWM, and(3) Design and implementation of modulators for adjustable speed electric drives with synchronized PWM, per forming of experimental verification of the most promising methods and techniques of PWM.Academic impact of the investigation lies in further development and deepening of knowledge in theory of pulse modulation as an important part of science, engineering, and technology. Novel fast algorithms of PWM can be used by practical engineers working under design of electronic converters and drives.The project has also a dual education component, because:1) explanation of new methodology can be used in teaching courses in Elec.En
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A new technology to probe molecular interaction in cells at high throughput' (DiffusOMICS) targeting Horizon Europe.

assistant: **Abstract**

Protein oligomers and aggregates are pillars of many cellular processes and can be associated with a number of life-threatening neurodegenerative diseases. These processes are often context-dependent but are hard to detect in situ with available technologies. The ideal instrument can target specific proteins of medical interest in their physiological contexts, resolve nano-distances (1-100 nm) and capture dynamics of association and dissociation (ns-ms).The DiffusOMICS project aims to fill this methodological gap by prototyping a high-throughput fluorescence-based approach able to measure the rotational diffusion properties of molecules in vivo and in situ. The concept is based on our recent publication, where we utilize intelligent fluorescent probes together with polarized light to investigate the rotational dynamics of large molecular complexes. Rotational diffusion is highly sensitive to change in mass making the technique ideal to detect the presence of aggregates and report on molecular size and local viscosity. Due to the nature of the signal, the measurements can be done in cells and tissues at high throughput, making the technology appealing for industrial screening applications. The goal of the project is to establish both the technological foundation and the collaborations needed to develop a prototype instrument and to record the very first high-throughput molecular interaction maps in neurons. DiffusOMICS possesses all the essential qualities to become a game-changing technology for drug screening due to its sensitivity, specificity and speed, making it suitable for automated recordings. DiffusOMICS maps will carry information on the whole population of aggregates localized in different neuronal compartments and can track changes in aggregation responses to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sol-gel environmental agents sensors. design, production and characterisation' to be submitted under Sixth Framework.

assistant: **Abstract**

This scientific proposal is planned on the basis of former good results reached in basic research on sensitive sol-gel systems (sensors). Such sensors are formed by doped thin coats (200-500 nm) and, among others applications, they can be used for detection or measurement of environmental parameters affecting negatively the integral conservation of historical and cultural materials and objects. After the obtaining of the PhD degree, the applicant does continue studying sensitive sol-gel systems and other applications of sol-gel coats for protection purposes. In the present proposal, the development and optimisation of environmental acidity sensors, started in the PhD research, is planned. Likewise, other sensitive sol-gel systems against environmental parameters, such as temperature, light and relative humidity are envisioned.This is because they synergically deteriorate the major part of cultural heritage materials together with acid pollutants. Sol-gel systems as planned here incorporate different dopants (chromophores) into the polymeric and microporous gel structure, in such a way that the optical reversible properties of chromophores are preserved, once immobilised in the solid-state gel matrix. These sensors are easy to handle, maintain and transport, being obtained under a low-cost production process. The sensors are based on optical response (absorption, transmission, luminescence). The workplan scheduled is attainable in time, realistic and coherent with the proposed objectives.Moreover, by means of that workplan, a new family of environmental sensors useful in preventive conservation tasks of cultural assets will be produced. The present proposal inputs an added value from the technological point of view: it balances research results and real applications. In
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Case-only study on the interaction of diet and genetic predisposition in the occurrence of breast cancer in young women.'.

assistant: **Innovation**

The breast cancer (BC) risk of women with germ line mutations of Becalm or 2 or other high entrance genes is dramatically increased especially at young ages .Dietary and other modifiable life-style factors, however, may influence the early occurrence of BC in mutation carriers. Fruit and vegetable, vitamin E , say products and low glycaemia index food, as well as a low index of abdominal obesity , have been suggested to confer greater protection against hereditary Bethany against sporadic BC. Mechanistic explanations include hormonal effects of diet and antioxidant protection in women with impaired DNA repair. This CASE-ONLYSTUDY aims at testing exposure in patients with and without genetic predisposition, as established through family history or genetic testing. The study base will comprise over 5, 000 patients who got BC before the age of 40 .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A knowledge base for intermodal passenger travel in Europe' in the context of a Sixth Framework call.

assistant: **Objectives**

Journeys are often undertaken by car or airplane in cases where reasonable modal alternatives exist -for a journey's major stages. Reasons for such modal choices are in many cases the lack of integration of transport modes or the limited abilities of individuals to combine different modes by themselves. Additionally transport operators have only limited information about the market potentials for integrated transport services. Significant deficiencies still exist in the knowledge about current and potential intermodal demand and supply.The main objective is therefore the provision of a knowledge base (KB) on intermodal travel in Europe. This KB shall comprise all relevant information about passenger intermodality, can easily be accessed and allows stakeholders to develop and evaluate intermodality-related measures. The KB will be a core element to support a complementary Coordinated Action (Forum). It will allow to integrate and to disseminate existing information and data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on '3D Forest Structure Monitoring and Mapping'.

assistant: **Innovation**

ForeStMap aims at developing an innovative methodology to derive 3-D information on forest structure at different scales, local to regional, based on a multi-source RS data (multispectral, LiDAR and SAR). A 2-phase approach will be applied. First local estimates from airborne data will be provided and will be subsequently used as reference data to up-scale estimates to a regional scale based on satellite data. An innovative aspect of ForeStMap will be the joint use of empirical non-parametric methods and radiative transfer modelling (RTM). Real and data simulated under different scenarios will be used to develop algorithms to derive forest structure. RTM able to simulate multispectral, LiDAR and microwave data will be combined. Uncertainty of the estimates will be provided by considering error propagation. To validate the methods study sites have been selected in forest with very different characteristics (Tropical, Temperate, Boreal and Mediterranean). ForeStMap will be very useful for future European satellite missions, including Sentinel-I & II and Biomass, reinforcing the position of ERA in carbon accounting, forest monitoring and climate change adaptation. The ERA will also benefit from the synergies between the collaboration networks of the fellow and the host organizations, due to its structuring effect.An important aspect of ForeStMap is the training of the researcher. A detailed plan has been scheduled for the 3 years of the project to provide me with the necessary skills to ensure the success of the project and my future research career. I have a strong research track record showing great promise to establish myself as a leading researcher in the field of forest structure and RS.ForeStMap envisages a wide range of outreach activities (Master classes, summer sc