RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fostering sustainability and uptake of research results through Networking activities in Black Sea & Mediterranean areas' (IASON).

assistant: **Innovation**

IASON Project has the ultimate goal to establish a permanent and sustainable Network of scientific and non-scientific institutions, stakeholders and private sector enterprises belonging in the EU and third countries located in two significant areas: The Mediterranean and the Black Sea regions. The main focal points of the project will be the usage and application of Earth Observation (EO) in the following topics:•climate change•resource efficiency•raw materials managementIASON aims to build on the experiences gained by 5 FP7 funded projects, OBSERVE, enviroGRIDS, GEONETCab, EGIDA, and BalkanGEONet. All of the above projects focused on enhancing EO capacities, knowledge and technology in the EU and in neighborhood countries. During their execution time they managed to establish links with a critical mass of research institutions, organizations, public organizations, stakeholders, and policy makers in the Balkan region, the Mediterranean, and the Black Sea Basin.IASON intends to create the proper conditions for enhancing knowledge transfer capacity building, and market opportunities in using EO applications and mechanisms in specific research fields that are addressing climate actions resource efficiency and raw materials management.In order to achieve its goal IASON will engage in•Visible and effective capacity building and knowledge transfer activities with Third countries' research institutes and organizations, stakeholders and policy makers through the organization of two training workshops (one in each region).•Demonstration of market opportunities through uptake of results from three projects (PEGASO, enviroGRIDS, and IMPACTMIN), best case scenarios and success stories.•Identification of projects and networks, using the regional partners’ contacts in the Third Count
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The temporal dimension in functional Genomics' to be submitted under Sixth Framework.

assistant: **Abstract**

Knowledge on regulatory genes and mechanisms for their expression along time scales is undergoing rapid progress. The 'time' dimension turns out, therefore, to represent a common denominator in various systems studied in different disciplines. It is now of primary importance to bring together the array of expertise available on the different time scales in different biological systems to develop novel concepts, approaches and frameworks, and coordinate endeavours.On this basis, PROUST focuses on the functional genomics of 'timing' as a key issue to be taken into account for the understanding and monitoring of functions at the molecular, cellular and system levels, in health and disease. PROUST will emphasize that the temporal dimension is also crucial for drug development and discovery, as well as personalized medicine. Therapeutic approaches to different diseases will increasingly rely on the finding of a new 'grammar', by which the potential of the genome will move beyond individual genes and proteins to identify candidate drugs acting on common intracellular signalling pathways. PROUST will introduce and unravel the element of time in such new 'grammar' across lifetime, gender and diseases. The project is based on a consortium of 4 partners with complementary expertise, linked to a highly interdisciplinary panel of experts. To obtain its goals, PROUST will structure activities by arranging two meetings, one conference, two training courses and a position paper with the objectives to: 1. bring together scientists from different fields of research, in order to establish leading-edge projects with dimension of time in the focus;2. coordinate knowledge on the 'timing' of functional genomics, to identify therapeutic targets with time-dependent optimal susceptibilities; 3.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Novel Light Synthesizer' under Seventh Framework.

assistant: **Concept**

We propose the commercialization of a new generation laser pulse shaper, the light synthesizer. The device  will permit for the first time applications in science and technology that require shaping of light waves over the entire range of the  visible light spectrum and beyond, the ultraviolet and the infrared. Thanks to its broadband operation, the device will enable a new generation of of applications in ultrafast science and technology that may  dramatically influence attosecond and femtosecond photonics,  lasers based nonlinear microscopy as well as ultrafast studies and imaging in biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'GRACE: Gender and Cultures of Equality in Europe'.

assistant: **Innovation**

The aim of the GRACE (Gender and Cultures of Equality in Europe) project is to systematically investigate the cultural production of gender equalities within Europe. Extending the success of GEMMA, the Erasmus Mundus ‘Masters of Excellence’ in Women’s and Gender Studies, the central objective of GRACE is to become the programme of reference for innovative interdisciplinary doctoral training for early career researchers. Previous scholarly work focuses on European gender equality policies. GRACE draws on innovative and interdisciplinary methodologies to investigate an under-examined aspect of those processes, namely the production of cultures of equality that underpin, enable and constrain those changing policy and legislative frameworks. Our methodological approach understands culture as neither normative frameworks nor ways of representing the world, but more fundamentally as the process through which people create the worlds they inhabit. The GRACE project will recruit, employ and provide advanced training for 15 ESRs who will research the production of cultures of gender equality across five specific sites where cultures of gender equalities are produced and contested by differently situated social agents. These five sites form the core of our research and training Work Packages, and are focused as follows: mediated cultures of gender equality (WP 1); urban cultures of gender equality (WP 2); intellectual and activist cultures of gender equality (WP 3); textual and artistic cultures of gender equality (WP 4); employing cultures of gender equality (WP 5). In sum, GRACE is designed to: equip the next generation of ESRs to play a leading role in developing advanced techniques for investigating the production of cultures of gender equality; translate creative and critica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'INclusive Health And wellBeing In small and medium size ciTies' (IN-HABIT) targeting Horizon 2020.

assistant: **Abstract**

Four peripheral small and medium size cities (SMSCs) - Cordoba (Spain), Riga (Latvia), Lucca (Italy) and Nitra (Slovakia) – will take the leadership to test visionary and integrated solutions to foster Inclusive Health and Wellbeing (IHW) in SMSCs with a focus on gender and diversity. IN-HABIT visionary approach consists on the innovative mobilization of existing undervalued resources (culture, food, human-animal bonds and environment) to increase IHW. The integrated approach is based on the combination of technological, digital, nature based, cultural, and social innovations in selected urban public spaces. These solutions will be co-designed, co-deployed and co-managed with and by local stakeholders. The effects on mental health, wellbeing and healthier lifestyles of these solutions will be evaluated and a sound scalable evidence-base and monitoring framework delivered. A systemic urban planning framework will be developed based on innovative gender and diversity approaches to boost IHW that will represent a unique reference for SMSCs. IN-HABIT will base its actions on underserved areas and vulnerable target groups existing in each city (such as, children, elders, women, persons with disabilities, ethnic minorities), and on the integration of ‘hard’ and ‘soft’ visionary solutions articulated around heritage and culture (as a nexus for inclusive societies), food (nurturing daily healthier lifestyles), animals (human-animal bonds as new relational urban goods) and art and environment (to connect places and people). Bogotá city will share know-how and replicate experiences. These actions have attracted the interest to be replicated by other twin-cities and networks of cities, that have shown their interest in establishing synergies with IN-HABIT and replicating actions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Spatial heterogeneity of tumor and CD8+ T cell metabolism in liver metastasis'.

assistant: **Concept**

While immune-based therapies targeting CD8+ T cells have transformed melanoma treatment, many patients still show inconsistent responses between primary tumors and metastases, particularly in the liver. CD8+ T cells face unique barriers in liver metastases, hindering their infiltration and suppressing their function. Recent studies show that CD8+ T cells adapt their metabolism based on the nutrients available in the tumor environment, and this metabolic adjustment plays a key role in their ability to fight cancer. Liver metastases have traditionally been studied as uniform in CD8+ T cell activity and metabolism; however, our findings reveal that each metastasis creates a distinct metabolic environment that impacts CD8+ T cell infiltration and function. This challenges the conventional view and highlights the hidden heterogeneity driving resistance to immunotherapy. Building on this, the SpaceMet project will address the three following key objectives. (1) Identify the functional mechanisms by which metabolite heterogeneity impacts CD8+ T cell infiltration and function. We will investigate the metabolic heterogeneity revealed through spatial metabolomics in mouse liver metastases using an in vitro assay that simulates CD8+ T cell infiltration and interaction with tumor cells under specific liver-like nutrient conditions. (2) Investigate to which extent the genetic background and cell of origin determine the formation and composition of heterogeneous metabolic environments in the liver. This will involve performing spatial metabolomics and immune profiling of liver metastases from melanoma with different genetic profiles, as well as from other cancers. (3) Advance metabolism-targeted immunotherapy for liver metastases towards preclinical applications. To achieve this, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biopolymer-Based Nanoparticle “Smart” Drug Delivery Systems and their Biopharmaceutical Application by Oral Administration' (2007-2013).

assistant: **Concept**

This initiative aims to gain both fundamental understanding and applied knowledge on novel polysaccharide-based nanoparticles to be utilized as ‘smart’ advanced delivery systems of therapeutic biomacromolecules for oral administration. To this end, nanoparticles will be harnessed from chitosan and other polyionic polysaccharides of biomedical use, cross-linked with a natural non-toxic biocompatible agent. Sensitivity to changes in temperature and pH will be conferred by modifying the surface charge (zeta potential) by modifying the local hydrophilic/hydrophobic balance the nanoparticle surface. While sensitivity towards two biomolecules of therapeutic significance will be achieved by modifying the nanoparticle surface by molecular imprinting, using a non-covalent approach. Phase transitions in these systems will be investigated by means of biophysical techniques including dynamic light scattering and SAXS (small-angle X-ray scattering). The adsorption capacity and selectivity of the molecularly imprinted surface will be studied by quartz crystal micro balance with dissipation mode (QCM-D) techniques. The in vitro release profile will be evaluated as a function of the presence of the external stimuli (temperature, pH and concentration of specific molecules). Citotoxicity and cell uptake will be evaluated in Caco-2 cell monoculture and the biopharmaceutical performance will be evaluated for selected prototypes after oral administration in a rat model.the biopharmaceutical performance will be evaluated after oral administration in a rat model.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Natural Resources and Armed Conflicts under International Law: Rationalizing a Heterogenous Legal Framework' (NATRESACIL) targeting Seventh Framework.

assistant: **Abstract**

The project aims to investigate the relationship between armed conflicts and natural resources under international law. The research begins from the assumption that the linkage between natural resources and armed conflicts is evident and multi-faceted in nature. It can be analyzed from four different perspectives. In their relationship with armed conflicts natural resources can be: a) A concomitant cause; b) An object of the destruction brought about by the hostilities; c) An object of the exploitative activities during the occupation phase; d) A factor inducing a change in the political and economic order of the (occupied) territories and the States. After having broached some preliminary issues concerning the definition of natural resources, the project will engage with the international rules and principles that are applicable to the phenomena described above. The analysis will consider the rules regulating access to natural resources in the pre-conflict phase; the rules protecting the resources pending the conflict; the rules regulating the exploitation, the ownership, and the legal regime of the resources during and after the occupation. Different bodies of rules such as the law on the use of armed force, the law of war and the law of occupation, international environmental law, international commercial law, human rights law and permanent sovereignty over natural resources will be investigated. The ultimate objective of the project is to identify the antinomies and understand the interaction between the relevant legal regimes. Another objective lies in applying a coherent set of interpretive and systemic tools with the aim of reducing fragmentation and inconsistencies. The research method will make reference to the sources of international law and to the practice o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cold Molecular Ions at the Quantum Limit' (COMIQ).

assistant: **Concept**

COMIQ (COld Molecular Ions at the Quantum limit)will investigate how cooling, trapping, and control techniques applied molecular ion can expand the realm of quantum technology, enhance precision meaurements on molecular systems and lead to chemistry at the ultracold quantum limit.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Project on the cycle/chain of plant fibres starting from production up the processing and transformation into biodegradable packing products.' (1998-2002).

assistant: **Innovation**

The proposal is aimed at design of a complete Cycle/chain for plant fibres (hemp, linen, knead, sorghum etc.). The successive stages of the cycle are: cultivation and harvesting; processing and conversion to obtain a part-processed product for use as a raw material in the manufacture of biodegradable packaging for organic" food products. The Project is proposed with a view to offering a final product/result obtained from plant sources and biodegradable as an alternative to the throwaway plastic packaging currently widely used. The resulting product will contribute to reduction in waste arising in both manufacture and at the consumer level, in addition to reducing the health risks involved in processing, handling and contact with plastic raw materials. Attainment of the final result (Step 2, CRAFT) will be guaranteed by the strategies and work methodologies adopted for carrying out of the project, aimed at integration between research and production and synergies between the various European partners (the SME proposes of Step 1 and the partners to be sought for Step 2, to complete the consortium) working in the fields of agriculture, industry and commerce."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'GENEtic DiSsection of Innate Immune Sensing and Signalling'.

assistant: **Objectives**

In vertebrates, a receptor-based, innate sensing machinery is used to detect the presence of microbederived molecules or the perturbation microbial infection causes within the host. In the context of viral infection, non-self nucleic acids are sensed by a set of intracellular receptors that upon activation initiate broad antiviral effector responses to eliminate the imminent threat. Over the past years our understanding of these processes has considerably grown, mainly by employing murine knockout models.Recent advances in genome engineering now provide the opportunity to knockout genes or even to perform functional genetic screens in human cells, providing a powerful means to validate and generate hypotheses. We have developed a high-throughput genome targeting and validation platform that allows us to tackle large-scale loss-of-function studies both at a polyclonal as well as an arrayed format. In addition, we have invested considerable efforts to render this technology applicable to study innate immune sensing and signalling pathways in the human system. GENESIS will combine these efforts to tackle pertinent questions in this field that could not have been addressed before: We will systematically dissect known nucleic acid sensing pathways in the human system to explore their unique roles, cooperativity or redundancy in detecting non-self nucleic acids. We will perform polyclonal, genome-wide loss-of-function screens to elucidate signallingevents downstream of intracellular DNA and RNA sensing pathways and their roles in orchestrating antiviral effector mechanisms. Moreover, in a large-scale perturbation study, we will specifically address the role of the kinome in antiviral innate immune signalling pathways, exploring the role of its individual members and their epi