RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Resource spirits: An interactionist approach to animism and extractivism in Southeast Asia'.

assistant: **Objectives**

Indigenous populations in Southeast Asia and elsewhere have become a major source of inspiration for more sustainable relations with the environment. Their animist orientations – attributing agency, personhood or spiritual powers to the non-human world – is what prevents them from treating the environment as a resource to be exploited. Extractive industries, by contrast, are seen to objectify the environment as an entity separate from human beings, which is what allows them to extract resources at an industrial scale. Through long-term ethnographic research in Indonesia, Malaysia, the Philippines, and Timor-Leste, this project investigates how natural resource extraction affects people’s diverse relations with the environment. However, rather than pitching indigenous communities against extractive industries, this project’s conceptual step-change consists in the development of a social interactionist framework that examines how animism and extractivism are constituted through their interactions. The hypothesis is that we find extractive logics within animist practices and that animist assumptions might also be uncovered within extractive industries. The focus on interaction allows us to determine whether animist orientations truly ‘protect’ against extractivism and how multinational corporations counteract criticism by incorporating the very logics on which this criticism is based. Ethnographic studies of resource extraction tend to be dominated by single cases, focussing on indigenous opposition and the incommensurability between indigenous and modernist ways of relating to the environment. The methodological innovation of this project lies in its comparative multi-scalar approach. Through historically informed, long-term ethnographic case studies in four Southeast Asi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Geometric phases, pumping, and dissipation in quantum devices' (GEOMDISS) targeting Seventh Framework.

assistant: **Abstract**

The aim of this project is to investigate how dissipation influences the geometric phases and geometric pumping in quantum solid-state devices and to assess the role of geometric manipulations in future ICT applications. Since all realistic solid-state devices suffer from dissipation due to their coupling to uncontrolled environment with many degrees of freedom it is crucial to understand how the geometric effects are modified and whether they are still useful.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Avoidance of vibration in paper calendering equipment by numerical optimization' (1998-2002).

assistant: **Innovation**

Avoidance of vibration in paper calendaring equipment by:1.) Basic research by measurements and numerical calculations,2.) Verification of calculation model with real calendaring equipments 3.) Optimisation of calendaring equipments by developed calculation models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AnEUploidy: understanding the importance of gene dosage imbalance in human health using genetics, functional genomics and systems biology' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Aneuploidy refers to abnormal copy number of genomic elements, and is one of the most common cause in morbidity and mortality in human populations. The importance of Aneuploidy is often neglected because most of its effects occur in the embryonic and fetal period. The prototype of extra genomic material is trisomy 21 (Down syndrome), and some common microdeletion syndromes are the models of monosomies. It is likely that numerous other unknown pathologic conditions (including common phenotypes) are due to segmental aneuploidies. In addition, an extensive variability of the copy number of numerous genomic regions is polymorphic in human populations. Aneuploidy is related to gene expression perturbation and abnormalities, but the molecular pathogenesis of the numerous aneuploid disorders is largely unknown.This grant proposal has the ambitious goals of contributing to the understanding of the molecular basis and pathogenetic mechanisms of aneuploidies. The experimental strategies proposed use the recent achievements of human genome sequencing, comparative genome analysis, genome variation, mouse transgenesis, technological platforms for transcriptome and genotypic analysis, bioinformatics tools, and systems biology. The specific goals of this interdisciplinary project are to: i) link abnormal phenotypes with gene copy number alterations; ii) identify novel conditions due to aneuploidy; iii) study the gene overexpression and transcriptome dysregulation in mouse embryonic stem cells; iv) produce and study mouse models of aneuploidy; v) identify functional genomic elements that are important for aneuploidy; v) integrate and interpret the results of genome dysregulation.In addition, this proposal builds on the excellence and competitiveness of European laboratories in the fiel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Active Matter: From Fundamental Science to Technological Applications' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

During the last decade, active matter has been attracting increasing interest because its study can shed light on far-from- equilibrium physics and provide tantalizing options to perform tasks not easily achievable with other available techniques on the micro- and nanoscale. We are now on the threshold of breakthroughs that will permit us to gain a deeper understanding of the fundamental challenges associated with far-from-equilibrium physics (e.g. the physics of living organisms, tissue formation and cancer growth) and to address several key technological challenges of great societal and economic impact (e.g. biomimetic materials, targeted localization, pick-up and transport of nanoscopic cargoes in drug delivery, bioremediation and chemical sensing). However, there are still several open challenges that need to be addressed in order to achieve the full scientific and technological potential of active matter in real-life settings: 1. to develop biocompatible active particles, reducing their footprint by scaling them down towards the nanoscale; 2. to determine their emergent and synergistic behaviors in complex and crowded environments; 3. to engineer self-assembly in dense active and living matter systems. This ETN will provide the necessary infrastructure to train a new generation of physicists in the highly interdisciplinary fields related to active matter. ESRs will master the theoretical, numerical and experimental tools currently employed in the study of active matter, will create new tools for understanding active matter systems, and, through collaboration with companies, will be able to transfer this knowledge to biomedical, bioremediation and sustainability applications. Our ESRs will acquire highly demanded transferable skills increasing their future employabi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Super-peer semantic search engine' (ALVIS).

assistant: **Concept**

The project will conduct research in the design, use and interoperability of topic-specific search engines with the goal of developing an open source prototype of a distributed, semantic-based search engine. Existing search engines provide poor foundation for semantic web operations, and are becoming vital access paths to the Internet.Our approach is not the traditional Semantic Web approach with coded or semi-automatically extracted metadata, but rather an engine that can build on content through automatic analysis of free text. Linguistic processing will be inside the search engine and a probabilistic document model will provide a principled evaluation of relevance to complement existing standard authority scores. This will facilitate semantic retrieval and incorporate pre-existing domain ontologies using facilities for import and maintenance.The distributed design will be based on exposing search objects as resources, and on using implicit and automatically generated semantics (not ontologies) to distribute queries and merge results. Because semantic expressivity and interoperability are competing goals, developing a system that is both distributed and semantic-based is the key challenge: research will involve both the statistical and linguistic format of semantic internals, and determining the extent to which the semantic internals are exposed at the interface. The consortium assembles a team of leading international researchers from the areas of peer-to-peer computing (P2P), information extraction and search, and probabilistic modeling together with some of Europe's leading SMEs.The combination of design goals, the distributed operation and open source development have been chosen to support incremental growth, third-party involvement, low barrier to entry, and nex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BASELINE DATA FOR USER VALIDATION IN INFORMATION ENGINEERING' to be submitted under Fourth Framework.

assistant: **Abstract**

BASELINE is an action to support the needs of information engineering projects as regards planning and executing so-called usability engineering and user validation activities. Support will include up-to-date information about cost-benefit-related aspects of suitable methods for these activities and an e-mail help desk. The action will pool project validation results into reference values to be exploited by the projects or other users for the design of new electronic information applications or comparison with their own results. The information collected will be disseminated in joint meetings, on the World Wide Web (http://www.ucc.ie/hfrg/baseline) and elsewhere.Information Engineering projects will be provided with support for their user validation activities, including: - up-to-date information about cost-benefit related aspects of suitable methods for user validation and usability engineering in the Information Engineering domain;- an email help desk for questions concerning user validation and usability engineering in general;- baseline usability data (synonymously used term is 'reference values') for electronic information applications;- information about new approaches and methods relevant for usability engineering in the Information Engineering domain.  The project will collect:- relevant information about the practicability and cost-benefit of currently applied usability engineering methods and procedures;- validation results from Information Engineering projects.  The project will pool validation results from Information Engineering projects into reference values which can be used by Information Engineering projects and the wider Information Engineering audience either as baseline information for the design of new electronic information applications or to compa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Surface phenomena and new reagent scheme for separation of feldspars from Quartz' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content:The separation of feldspars from quartz by flotation applying the conventional HF-method is no longer acceptable from an environmental and health point of view. Moreover, new ceramic composite materials require high quality components for their industrial scale production. Therefore, the search for anew reagent scheme for selective and efficient separation is under serious consideration. Since only the selective modification of surface hydrophobicity of minerals components gives basis for their successful selective separation by flotation, the detailed surface characterization will be one of the goals of the project. The second objective is the proposition of a new reagent and flotation scheme for separation feldspars from quartz. Three groups of reagents more selective than those conventionally used are proposed for investigation. In this project, the metal cations activation and depression of the minerals in conventional anionic and cationic flotation, and the chelate/complex forming agents for feldspar - quartz separation will be explored through fundamental to pilot plant studies.The main objectives of this project are: (i) the acid-base properties of the mineral water interface, (ii) surface complexation of metal cations that constitute the mineral lattice and isomorphous, (iii) surface complexation of the reagents leading to the evaluation of surface complexation constants, (iv) detail spectroscopic surface characterization of the nature and structure of the adsorbed new reagents on minerals (adsorption mechanisms, orientation molecules in the adsorption layer) in order to evaluate criteria for designing of the optimal structure of the new reagents for selective separation, (v) X optimisation of physicochemical parameters of selective adsorp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and implementation of an integrative bioanalytical approach to identify sources of toxicity formed during ozonation of wastewater' (OzoToxID), addressing dissemination and exploitation.

assistant: **Impact**

Organic micropollutants (MPs) such as pharmaceuticals, industrial chemicals, and biocides cause undesired effects in the aquatic environment when present above certain concentrations. Conventional wastewater treatment plants (WWTPs) are major point sources of entry of MPs into watercourses, leading to disturbances in the ecosystems of receiving water bodies and potentially to a negative impact on the quality of drinking water resources. Several European countries have started upgrading their WWTPs to reduce discharges of MPs into water bodies. Ozonation is one of the two main technologies used to upgrade WWTPs. The abatement of MPs by ozone has been shown to reduce certain toxicities such as endocrine disruption and algal toxicity. However, toxicological studies which investigated mutagenicity and genotoxicty –two endpoints relevant to carcinogenicity– revealed that ozonated wastewater exhibited mutagenic and genotoxic activities, which were not present before ozonation. To date, the nature of mutagenic and genotoxic ozonation transformation products and byproducts (OTPs and OBPs) as well as their precursors has not been elucidated. Owing to the large number of MPs present in wastewater effluents, testing each compound individually is not a feasible option. Consequently, an integrative strategy that prioritizes identification and targets the mutagenic and genotoxic compounds after toxicity assessment is necessary. OzoToxID aims at developing and implementing an integrative bioanalytical strategy based on effect-directed analysis combining mutagenicity and genotoxicity bioassays, fractionation, and cutting-edge high-resolution mass spectrometry chemical analysis to identify mutagenic and genotoxic OTPs/OBPs, determine their precursors, and elucidate their formation pathw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrin ligands containing novel constrained amino acids - Synthesis, structure analysis, and biological evaluation' (2002-2006).

assistant: **Innovation**

The interdisciplinary project addresses research issues on the borderline between bioorganic chemistry, biochemistry, and medical sciences. It focuses on an important class of proteins, the integrins, employing organic synthesis of novel conformationally constrained amino acids, incorporation of such building blocks into peptides, as well as structural and functional characterization using methods of protein biochemistry, cell culture, NMR spectroscopy, and biophysical analysis. Integrins are heterodimeric cell surface glycoprotein receptors, involved in cellcell and cellmatrix adhesion.The interaction of integrins with ligands is the molecular basis of physiological or pathological processes, such as platelet aggregation, tumour cell adhesion, wound healing, internalisation of pathogenic bacteria or leukocyte adhesion. Small molecules that interfere with this interaction can efficiently influence the cell-cell and cell-matrix interaction imparted by the integrin, being of potential interest in the therapy o f cancer and inflammatory diseases. The amino acid sequence RGD (arginine-glycine-aspartic acid), which is present on many of the natural ligands, is essential for the interaction between integrins and their corresponding ligands. Synthetic peptides containing the RGD sequence have emerged as promising starting point for the identification, synthesis and development of selective integrin ligands.The incorporation of novel modified and conformationally constrained amino acids can greatly affect the secondary structure of the peptide, in such way that the synthetic ligands prefer to adopt a particular conformation. Consequently, these amino acids serve as useful tools in the de novo design of biologically active peptides, since the spatial orientation of the pharmacop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Metabolism-YEATS-crosstalk: Elucidating metabolic dependencies of epigenetic YEATS action'.

assistant: **Objectives**

Metabolism and gene regulations act in concert to shape cellular identity and plasticity. One major line of crosstalk occurs through metabolites such as acyl-CoAs, which are inscribed on histones as posttranslational modifications (PTMs) to be subsequently recognised by reader proteins, resulting in initiation of specific transcriptional programs. The increasing identification of novel PTMs necessitates thorough characterisation, however still remain largely underexplored. For instance, the presence of non-acetyl acyl-Lys PTMs such as crotonylation with YEATS-reader proteins identified to bind these PTMs suggests complex gene regulation programs. However, despite the clinical relevance of YEATS-proteins in various cancers, little is known about their acyl-reading activity and transcriptional consequences. Therefore, this proposal aims to close multiple knowledge gaps regarding overall function and mechanism of the metabolism/acyl-PTM/YEATS communication axis. Considering the metabolic context, I furthermore propose epigenetic YEATS action to be determined by direct interactions with metabolic proteins. Thus, I will first establish an inducible YEATS-degradation platform to characterise the genomic context under various acylate conditions. Next, I will implement a fluorescence-based cell reporter system, which shall reveal putative interactors upon transfection with a CRISPR-KO library targeting metabolic enzymes. Lastly, hits will be biophysically characterized, their metabolic impact within the epigenetic context determined and co-dependencies on relevant cancer cell lines tested. The interdisciplinary approach entailing state-of-the-art chemical and molecular biology tools will be combined with high-throughput screening methods and bioinformatic analyses. Besides eluc