RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cross-scale concurrent material-structure design using functionally-graded 3D-printed matematerials.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The objective of the XS-Meta Innovative European Training Network project is to train a new generation of researchers in concurrent material-structure design of high-technology structural systems, using functionally graded 3D-printed metamaterials. By taking advantage of the unique technological opportunity that the revolution of 3D-printing (3DP) is bringing to industry and engineering, XS-Meta helps the European industry and future academic system by training a highly-educated, goal-oriented generation of scientists and engineers capable of developing high-tech, value-added products to maintain and increase its technological leadership, critical for high living standards in a global marketXS-Meta takes full advantage of new 3D printing (3DP) possibilities at the microscale, to design functionally graded (FG), optimally architected, mechanical metamaterials (MMs) best-suited for the demands at every location in a component. XS-Meta constitutes a multidisciplinary change of paradigm on how engineering structural design has been performed to date, integrating the metamaterial design concurrently with the structural design through double inverse analyses and surrogate continuum models obtained by data-driven techniques.XS-Meta is a highly multidisciplinary and intersectoral project, involving leading high-tech companies in their field, a National Industrial and Research Centre and complementary leading academic research groups. XS-Meta has the right combination of excellence in research, academic training and industry experience, and high international and intersectoral mobility for developing innovation-oriented, entrepreneurial and creative researchers. XS-Meta involves “hands-on” experience for the recruited Early Stage Researchers (ESRs), including developing all the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An environmental Standards Information Portal for Europe' (SIPE) targeting Seventh Framework.

assistant: **Abstract**

The aim of SIPE is to promote and increase the use of research results in support of Standards (related to the compartments air, water, soil and waste) to stakeholders from RTD, Standardisation bodies, policy and enterprises/SMEs. A dedicated www-based Standards Information Portal (SIPE-RTD) will be developed and implemented. Easy transfer of information is facilitated by an input module (SIPIS) and a document repository.An Interfacing Group, consisting of stakeholders’ representatives will be invited to comment on the initial concept and to steer the development of the portal. They shall be instrumental to ensure that SIPE-RTD develops into a fit-for-use and sustainable entity.EC FP-funded research projects in support of Standards and their results, and Standards related to the mentioned sectors will be listed. EC Directives in these areas and their policy tasks will be collated. The same set of keywords will be used to describe all data sets. This pool of (Standards related) keywords will be interlinked by algorithms into a ‘Categorisation scheme of keywords’. This scheme will be the basis for the interactions within and between the stakeholder communities, and be used for gap analyses.Information on RTD projects (and their results), information on Standards and Directives will be entered into SIPE-RTD. Short descriptions in non–scientific language will be entered together with web-links.To maximise dissemination to all stakeholders the target audiences will be defined and their networks/professional organisations will be mapped. Dissemination will be two-way: inform all stakeholders on the activities of the SIPE project and inform all on the benefits of SIPE-RTD as an important tool in communication between different Standards communities. The Interfacing Group and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ecosystem mechanisms of noise impact on marine fauna' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Defining a Good Environmental Status for ocean noise within the EU Marine Framework Strategy is challenged by our limited knowledge about noise effects on marine fauna.ECOSOUND proposes that there are two broad types of mechanisms of noise impact on individual animals, both with potential population-level effects: bottom-up, i.e. noise responses that operate at the genetic, cellular or physiological level, which are likely to be conserved across taxa; and top-down, i.e. behavioural reactions driven by the life style of each species, which may result in physiological damage and even death.ECOSOUND will study bottom-up effects exploring if noise may induce morphological changes in several invertebrate taxa, selecting study species known to show phenotypic plasticity when exposed to stressors. Identifying developmental mechanisms of noise-effects is critical to predict potential common physiological paths over a wide range of taxa.Top-down effects will be investigated by comparing the life style of four species of deep-diving whales, and developing models to identify the reasons and potential consequences at the individual and population level of the different vulnerability of these species to noise. ECOSOUND will use the largest existing dataset of multi-sensor acoustic tag recordings of these whales, and apply quantitative ecology methods to develop bioenergetics models linking foraging and diving behaviour, metabolic rate, life history and social structure of the species.The results will inform transfer functions for PCAD models of population consequences of acoustic disturbance.ECOSOUND will strengthen the multidisciplinary research profile of the fellow with the fields of developmental biology and quantitative ecology, while contributing expertise on cetacean biologgi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'digital based bio-waste derived meta-PANels Towards A REvolutionary building Identity' (PANTAREI).

assistant: **Innovation**

Buildings wield substantial influence on the environment, accounting for a hefty 30% of global energy usage and a consequential 19% of greenhouse gas emissions. To combat this looming crisis, the Net-Zero Energy Building (NZEB) concept emerges as a transformative paradigm shift in the world of construction.In the midst of this environmental renaissance, a digital revolution sweeps across manufacturing, presenting a tantalizing prospect of reducing embodied CO2 and enhancing thermal control. Yet, a considerable chasm separates these cutting-edge digital technologies from structures crafted from sustainable materials. The intricacies of computational and algorithmic design struggle to encapsulate the rich tapestry of Nature multi-scale marvels, the very essence of this green metamorphosis. Bridging this gap could boost digital fabrication to a mass production system, but issues include the complexity of multi-scale modeling, reliability uncertainties, technical limitations in 3D printing, and poor solution versatility.PANTAREI project addresses all these challenges by implementing a revolutionary adaptive intelligent computational irreversible thermodynamics paradigm to design and assess novel bio-waste-derived meta-structures for the reduction of embodied CO2 in buildings. PANTAREI over-arching aim is to extend the capabilities of current computational tools for material design, by developing adaptive solutions based on the intertwining of virtual physics of failure and non-equilibrium thermodynamics principles for the bio-waste multi-scale meta-structure design and tailored realization through the entire structure life-cycle with a human-centered perspective.This could be materialised only with the aid of a multi-disciplinary stakeholder coalition, which involves renown
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Support to the activities of the European Technology and Innovation Platform on Deep Geothermal' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overarching objective of the new ETIP-“Deep Geothermal” is to enable deep geothermal technology, in particular Enhanced Geothermal Systems (EGS), to proliferate and move from the current European R&D and pilot-sites to other European countries and different geological situations. The primary objective is overall cost reduction, including social, environmental and technological costs.The Geothermal ETIP is an open stakeholder group, including representatives from industry, academia, research centres, and sectoral associations, covering the entire deep geothermal energy exploration, production and utilization value chain.The European Technology and Innovation Platforms (ETIPs) have been recently recognised by the EC as a tool to strengthen cooperation with Stakeholders under the Strategic Energy Technology Plan (SET-Plan), as part of the H2020 programme.The geothermal sector created an European Technology and Innovation Platform on Deep Geothermal in March 2016, and the European Commission, DG RTD, officially recognised it as an ETIP in July 2016.A Geothermal Forum of stakeholders, including large companies, SMEs, academia and research institutions has been convened in March 2016.Terms of Reference (ToR) to establish the governance and procedures of the Geothermal ETIP were adopted in June 2016.This proposal aims at assisting the mission of Deep geothermal ETIP.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The Equitable, Inclusive, and Human-Centered XR Project'.

assistant: **Concept**

eXtended Reality (XR) technologies have within a few years moved from lab-based research to a common-place consumer item. Indeed, the benefits of and the possibilities that XR technologies offer to promote and enhance are prolific. As with other emerging technologies, however, the use and eventual ubiquity of XR technologies bring with them potential risks that have not existed before. Of particular importance are new ethical, and associated safety, privacy, security challenges and interoperability issues that needs to be considered now. Developing the foundations to ensure that Europe is sufficiently equipped to leverage these opportunities through skillful navigation of new challenges is the rationale for XR4HUMAN. The MAIN OBJECTIVE of the project is to co-create living guidance on ethical and related policy, regulatory, governance, and interoperability issues of XR technologies within a European community of practice. This main objective will be operationalized through the following specific objectives: EXPLORE (i) ethical issues; and (ii) related regulatory and governance issues; GUIDE companies and regulators through (i) Interoperability Guidance Document; (ii) a European Code of Conduct for Equitable, Inclusive, and Human-Centered XR Technologies; (iii) recording and demonstrating the practical application of the XR Code of Conduct;EQUIP companies and regulators with an online repository of test cases to allow developers to demonstrate evidence of adherence to best practices;EQUIP and GUIDE users through a rating system and educational materials;ENGAGE companies and other stakeholders (i) to enhance the uptake of the XR Code of Conduct, the Guidance for Interoperability, and the empowerment of end-users; and (ii) to establish a permanent digital European Forum to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Exploring lamin-lipid interactions and the loss of nuclear structural integrity as the molecular determinants of human aging'.

assistant: **Innovation**

Aging is a major risk factor for many human pathologies. At a time when we are living longer than ever before, untangling the mechanisms of this biological deterioration is absolutely critical if we aim at providing a better quality of life for aging individuals. The loss of nuclear integrity, and the consequent defects in nuclear mechanics, is already among widely considered hallmarks of aging. In mammalian cells, the structural properties of the nucleus are maintained by the nuclear lamina (NL), especially lamin A (LA), and its interaction with the nuclear envelope (NE). In this innovative project, our working hypothesis is built upon the observation that progerin – truncated form of LA prevalent in premature aging – is abnormally associated with the inner nuclear membrane (INM) and the LA, due to its permanent farnesylation. Moreover, progerin levels were also shown to increase in healthy aged individuals, suggesting that LA and progerin differences in membrane association might be intimately involved in healthy human aging. Hence, the main goal of this project is to understand how the interplay between LA (at different proteolytic stages) and INM lipids affects NL architecture and nuclear structural integrity during physiological aging. To address this question, we will tackle lamin-lipid interactions (and lamin polymerization) in membrane models mimicking the NE during healthy and premature aging, and in intact nuclei, using a set of quantitative techniques, including fluorescence-based methods, atomic force microscopy and lipidomics. Overall, this is the first time a comprehensive lipid-driven molecular biophysics approach will be applied to the NE during healthy human aging. By achieving the proposed objectives, we will provide new knowledge on the role of INM li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Development of a microscopically realistic 3D Computer model of a Ventricular Wall to study microstructure-related mechanisms underlying the formation of post-shock Isoelectric Windows'.

assistant: **Innovation**

Several multicenter clinical trials have provided consistent evidence that implantable defibrillation therapy prolongs patient life. This convincing demonstration of the efficacy of defibrillation has led to a nearly exponential growth, over the last decade, in the number of patients receiving implantable devices.The current wide application of defibrillation raises new concerns regarding the safety and optimization of the therapy. Improved understanding of defibrillation mechanisms is therefore imperative to the development of better and safer strategies for prevention of sudden cardiac death.Despite the importance of this therapy, understanding of mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete. While recent experimental advances have provided new characterizations of tissue responses to shocks, mechanistic inquiry into the success and failure of defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behaviour confined to the depth of the ventricles.The overall objective of this research is, by employing realistic 3D computer simulations, to bring a new level of understanding of the post-shock events in the heart that lead to the failure of the shock.Current models do not incorporate anatomical micro-heterogeneities, which could play an important role. Specifically, this project proposes to examine, in bidomain models of cardiac micro-structure, mechanisms underlying the isoelectric window", the quiescent period often preceding the first post-shock activation following failed shocks.We hypothesize that the isoelectric window arises from small-scale shock-induced polarization, such as polarization of trabeculae and papillary muscle. Understanding the isoele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Superior cold recycling based on benefits of bituminous microemulsions and foamed bitumen. a efct system for the rehabilitation and maintenance of roads'.

assistant: **Innovation**

The key objective is to generalise and extend all over Europe the in-situ recycling of bituminous paving mixes with cold processes. The project aims at the development and validation (via test trial) of processes and formulation methodologies allowing to re-use any reclaimed material to its highest technical potential. Key fundamental aspects of the project are the characterisation of reclaimed materials, the interactions between cold applied new binders and aged bitumen, the design of a new process based on the use of micronised emulsions and foamed bitumen, the determination of final mechanical performance and its impact on pavement design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accelerating scale up and commercialisation of 100% bacteria free eggs for use in production of vaccines' (Ovavax2) under Horizon Europe.

assistant: **Objectives**

Ovagen is aiming to transform the egg-based production of vaccines and other biopharmaceutical medicines by producing the world’s first Germ Free egg and bringing it into mass production. The proposed programme of work will build on the groundwork initiated as part of the 30 month OvaVax project (GA 858390) and provides a logical expansion of this disruptive, innovative technology to the challenges facing the world as it comes to grips with COVID-19 and future pandemics with the need for rapid scale-up of vaccine production Ovagen is applying for EIC Accelerator funding to broaden the project scope of their existing H2020 SME Instrument Phase 2 to expand and accelerate the existing influenza project, to include COVID-19, Yellow Fever, Newcastle Disease and to include readiness for production and accelerated international scaleup of germ free egg production to increase global vaccine manufacturing capacity in readiness for future pandemics similar to COVID-19.


**Keywords:** Global scale-up,Yellow fever,Influenza,Coronavirus,Vaccine production,Germ-free eggs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Plant cell wall communication and remodelling: the wall watchers.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Plants, just like animals are highly developed multicellular organisms. In contrast to animal cells however, plant cells are surrounded by a rigid, carbohydrate-rich extracellular layer, the cell wall. This cell wall provides plants with mechanic support and a dynamic chemical signalling and metabolic environment. To allow for cell expansion, cell division, coordinated tissue growth and interactions with the environment, the cell wall status constantly needs to be sensed and modified. How plant cells perceive and signal their cell wall status is poorly understood. Here, I propose an integrated approach to uncover ligands for cell wall sensing receptors as well as their downstream signalling components. Specifically, my project aims to identify the ligands for two genetically validated cell wall receptor families, using a chemical biology approach. Next, we will analyse and validate the mode of ligand-receptor interaction by combining protein X-ray crystallography, quantitative biochemistry and reverse genetics in Arabidopsis. A detailed ligand-binding and receptor activation mechanism will allow us to specifically interfere with cell wall receptor function in vivo, and to assess their biological relevance for cell wall structure and its chemical properties. Using atomic force microscopy, we will then test if the receptors are distributed uniformly at the membrane or whether they are arranged in complex 'sensosomes'. Finally, we will characterize if plant cell wall receptors can directly act as mechanosensors. With defined receptor-ligand pairs and clear phenotypes at hand, we will try to uncover downstream signalling components for plant cell wall receptors and to validate our atomic models in planta. My ultimate goal would be to design and test cell wall receptor agoni