RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unbreakable HEART: a reconfigurable and self-healing isolated dc/dc converter (U-HEART)' (U-HEART) targeting Horizon 2020.

assistant: **Abstract**

Isolated dc/dc converters are increasingly employed as key components in data center, aerospace and electrical distribution, because of their capability to guarantee controllability and improve system efficiency despite power electronics is still more prone to failure with respect to other components of such systems. Fault-tolerant operation, when needed, is typically achieved through redundancy, which entails higher costs. The goal of U-HEART is to obtain fault-tolerant operation of the isolated dc/dc converter avoiding redundancy. This will lead to larger acceptance in industry, typically very skeptical when it comes to higher costs.  In 2017 we have applied for a patent  covering isolated dc/dc converters based on a multi-winding transformer, which can ride-through failures by means of the reconfigurability of the system and of the self-healing capacity of the cells. The hardware is reconfigurable because a part of the magnetic core with the associated winding and associated power module can be removed and self-healing because in case of a failure, the healthy part of the system realizes a different power converter function. The software will guarantee that the resulting dc/dc converter will be able to operate with one cell less or with its reconfigured version. The goal is that after a failure the overall system maintains the original functionality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'La race bovine somba - caracterisation et recherches en vue de son amelioration et de sa conservation', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The main objectives are as follows:* To get better knowledge of breed genetic variability, for further application in developing genetic improvement.* To evaluate the adaptative capacity of the breed to the environment and its natural resistance to major animal diseases.* To improve productivity through introduction of upgraded techniques to be developed through the project.* To determine selection programs and breed conservation plans for further funding.* Train and transfer of technologies to national research systems.* To enhance North-South partnership.Expected OutcomeThe work carried out in this project should provide guidance for selection and preservation of Somba breed which is endangered. It should give tools to identify the Somba breed. The program also highlights useful for conservation and improvement animal resources in Benin and Togo for the health and development of human population. The increasing of animal productions will improve social and economic environment of Benin and Togo.The activities are structured in target-phases:* Target phase 1* identification and analysis of socio-anthropological situation, in the area and of the typical raising systems for this breed (socio-economical and zootechnical study),* survey on animal health (cross-sectional and follow up studies in collaboration with partners in the project),* evaluation of genetic variability by hematic and milk proteins gene markers determination using biochemical methods and modern biotechnology (PCR, microsatellite).* Target phase 2* finding out targets selection programs through study on performances of production and morphometrical characteristics,* identification of morphometrical traits with strong economical interest to be selected* use of genetic material preservation techniques (cry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DEVELOPMENT OF NOVEL ANIMAL MODELS OF GLUTAMATERGIC CENTRAL NERVOUS SYSTEM DISORDERS USING IN VIVO SIRNA AND TRANSGENIC APPROACHES' in the context of a Sixth Framework call.

assistant: **Objectives**

Glutamate is the most abundant excitatory transmitter in the brain. However, very few models exist to explore the potential of drugs that modulate glutamate transmission. Because altered glutamate transmission is involved in numerous psychiatric diseases, there is a strong need for such models, to characterise the effects of hypo- and hyper-glutamatergic states on the onset and development of such diseases. AGLAEA will develop and characterise models of selective, partial knockdown of specific components of the brain glutamatergic system in mice. This will provide better comprehension of the implication of glutamate signalling in diseases such as schizophrenia, anxiety and cognitive disorders. AGLAEA will lead to breakthrough research on the neurobiological and neurochemical bases of psychiatric disorders and will enable the further testing of new drugs for treatment. In order to selectively turn off specific components of the glutamatergic pathways, an siRNA approach will be used. The effect of modulation of glutamate signalling will be characterised using functional MRI (fMRI) and microdialysis/microsensor analysis. Specific behavioural tests will be carried out on live animals for the assessment of glutamate-related psychiatric disorders. Furthermore, the data collected from siRNA experiments will be applied to the generation of transgenic mice, in which modulation of glutamate signaling will be induced at different stages of development. Therefore, AGLAEA will provide both the pharmaceutical and the academic world with potent models. These models will be used to test novel compounds and assess their therapeutic value and will benefit researchers investigating the neurobiological and neurochemical bases of those diseases.The consortium set up to reach the objectives
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Obtaining and development of a new soft magnetic material based on free-rotate nano-scale magnets' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This project deals with the fabrication of a new magnetic material for sensors and electrical transformers based on nanoscale ceramic magnets. This project will take place in two stages. In the first one we will concentrate our effort in both getting the nanoscale magnets dispersed in a polymer matrix and doing the magnetic characterization. In the second stage we will work on the developing of these materials having different size and shapes as magnetic cores for electrical and sensor applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Vacuum Medical Device for Safe and Gentle Cervix Grasping Gynecological Applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

For years, gynecologist practices related to Intra-Uterine Contraceptive Device (IUCD) insertions, curettage and several other common indications, have featured poor care and low attention to female patients. The use of the Tenaculum, grasping and pulling on the cervix, inside the vaginal cavity, proved to be painful and traumatic for 84% of the women, and eventually to trigger lesions and bleeding in 29% of the patients, as well as cross-contamination in 5-10% of the women. These disadvantages refrain the use of IUCD contraceptive which exacerbates the unintended pregnancies, sized yearly in 85 mills and representing billions of euros in social costs worldwide.In response, we have developed Aspivix, a new disruptive gynecological device that reduces the pain and eradicates the bleeding during the exploration procedure. Our patented device will replace the Tenaculum forceps, unchanged for over 100 years, to provide gynecologists an easy-to-use device where gentle and firm cervix uterus grasping and traction is needed. Thus, our device will facilitate the adoption of IUCD, which could avoid up to 8% of unintended pregnancies and reduce derived social costs. Besides, Aspivix is intended for a single use which prevents the risk of contamination and cross-infection. Overall, Aspivix has the potential to shorten the intervention procedure (2 steps instead 7), which will represent for the physician a 28% economic benefit. As result, Aspivix will fulfill the needs of more than 64 M of women worldwide/year, a market that is projected to grow at a CAGR2016-2021 of ~6.5% due to the high demand of IUCD insertions and is valued in more than €350M. In this way, thanks to the sales of 22M units in the European, Asian and North American Markets after 5-years, Aspivix will generate cum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spatio-functional cellular interplay in peripheral nerve diseases' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Neuromuscular disorders belong to the most common but least treatable neurological conditions and are caused by defects in cell types that together build the neuromuscular unit  motoneurons and their axons, glial cells and myocytes. Clinically, neuromuscular diseases share an impairment of motor function and the intimate functional relationship of involved cell types suggests overlapping pathological mechanisms. As our current understanding is largely confined to locally isolated processes, the present AxoMyoGlia proposal will undertake the ambitious approach to elucidate the spatial dimensions of the molecular interplay among the key cellular players of the neuromuscular unit. By taking demyelinating peripheral neuropathies as a powerful model system, I aim at unravelling basic principles of how local glial impairment propagates malfunction within the neuromuscular unit, including potential remote axon and muscle feedback mechanisms. To this end, I will employ neuropathic mouse models and generate a holistic transcriptional cellular interactome of the diseased neuromuscular unit at single cell resolution level. With milli- to nanometer imaging precision, this interactome will be extended to the first visualization of the spatial relation between glial and axonal dysfunction along the entire longitudinal dimension of the nerve. In order to untangle local and distant causes from consequences, I will develop an innovative mouse model that will offer the unprecedented option to specifically induce and examine the global consequences of locally restricted glial neuropathy at any position in the neuromuscular system. With its pioneering multimodal approach to converge different areas of neuromuscular research, AxoMyoGlia aims at uncovering general pathological mechanisms at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nano-structured TiON Photo-Catalytic Membranes for Water Treatment' to be submitted under Seventh Framework.

assistant: **Abstract**

More than 1.2 billion people, mostly in poor regions, suffer from water scarcity, due to a global shortfall of potable water caused by population growth, over-exploitation, and pollution. NATIOMEM proposes to alleviate this by developing novel technology for treating contaminated surface and waste water so that it will be potable. This technology will not require electrical power, chemicals or other logistical support, and hence will be suitable for poor areas lacking infrastructure. The technology uses membranes functionalized with a photocatalytic material, eg. N-doped TiO2 (TiON). Raw water will be directed through the membrane while it is exposed to solar radiation. The membrane will filter out particles and micro-organisms larger than the its pore size, and TiON photocatalysis will kill micro-organisms, decompose and mineralize organic pollutants, and oxidize dissolved metals, thus providing a one-step treatment against a broad spectrum of contaminants. In the NATIOMEM project, functionalized membranes will be developed with two approaches: (1) coating conventional membranes with TiON nanostructured films, using several candidate deposition methods, and (2) electrospinning TiON fibers, from which membranes will be fabricated. The functionalized membranes will be characterized for their morphological, physical, mechanical, chemical, and in particular, their photocatalytic properties, and the most effective will be extensively tested to determine their pollution abatement mechanisms and kinetics. A pilot plant incorporating these photocatalytic membranes will be designed, and field tested in the Middle East and in Africa. The results of these tests will be correlated with potential end-user requirements to set the stage for industrial exploitation. Achieving this res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Titanium Aluminide Turbochargers – Improved Fuel Economy, Reduced Emissions', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The TiAlCharger project aims to create a cost-effective, mass producible, low inertia titanium aluminide turbocharger assembly providing:• Weight savings of 60%• A reduction on mass moment of inertia of 36% (compared to Nickel super alloys that are the current state of the art)• Operation at temperatures >950°C• Increased fuel to air ratios thereby improving vehicle efficiency by an additional 5% and reducing  CO2 emissions reduced by 8%.The technologies behind this innovation are Electron Beam Melting (EBM) and Electron Beam Welding (EBW). The EBM process has the potential to fabricate a turbine wheel from successive layers of powder allowing a hollow, lightweight, low-inertia rotor-wheel to be formed. The TiAl wheel will be joined to the steel shaft using the EBW process, the challenge being to create a weld between dissimilar materials that is robust enough to withstand the vibrations, high temperatures and rotational speeds present in a turbocharger. This fabrication method provides the possibility to manufacture turbocharger wheels from TiAl, which (if of the required quality) retains its strength at high temperatures, expanding the usage of turbochargers to a broad range of engine types.The project will enable our SME consortium to:• Create a new IP protectable product giving us greater security from ever decreasing margins• Direct increased sales and revenues worth an estimated €58 million, creating/safeguarding ~176 new jobs p.a, by year 5 post-project (EU market)• Supply into a market technology that is expected to expand from 20% of US cars to over 85%, representing the potential to increase European exports by over >€200m by 2020.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Invertebrate discard viability and fitness in prawn trawl fisheries'.

assistant: **Objectives**

I have developed methodologies using physiological and behavioural measurements to assess the long term viability and fitness of Nephrops discards following capture by trawling (project FAIR CT95-0753). This approach, commended by the assessor of the project, uses important behaviours such as escape reactions, burrowing, defence responses, and the measurement of key physiological variables as indicators of the degree of stress to which fished animals are subjected. These predictors of fitness" will be applied in a previously unstudied context, namely the Portuguese prawn fishery, within the proposed collaboration. The host researchers, CCMar, will acquire this technology and experience of the approach, including on-board physiological sampling of blood and tissues. The results will increase our understanding of the condition and fate of discarded animals and allow comparisons between Northern and Southern fisheries of the consequences of trawling for crustaceans of commercial importance on non-target epibenthic and infaunal invertebrate populations and, therefore, seabed diversity.The research builds upon the expertise of both the Fellow and the CCMar group (Dr M.Castro-in-Charge), bringing together two aspects of fishery research to help to reduce the problems of ecosystem conservation and stock depletion created by discarding. This is a problem common to all trawl fisheries in the EU. The new methodology goes beyond considering survival per se, and examines a more complex condition of "fitness" in discards. Thus the findings will assist prediction of the longer - term viability of discards and their chances of success in re-colonising the seabed, avoiding predators and regenerating populations. It will provide new information to aid evaluation of the continued effects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Searching and Characterizing Extraterrestrial Subsurface Oceans'.

assistant: **Concept**

The existence of liquid water is one of the few preconditions for life as we know it. Therefore, the search and characterization of liquid water outside of Earth plays an essential role in the search for extraterrestrial life. Prominent candidates to host liquid water are moons in the outer solar system, which can maintain oceans under their icy surfaces. The currently most effective way to identify such subsurface oceans is through effects of their salinity and thus electrical conductivity. The conductivity modifies the magnetic field around these moons through a process referred to as electromagnetic induction. Spacecraft measurements of associated magnetic field perturbations provided evidence for oceans within Jupiter’s moon Europa and Ganymede. Current analysis tools however reached an impasse. No scientific techniques are available, which provide quantitative estimates and uncertainties of key ocean properties when the effects of the dense magnetized plasmas around the moons are included. Here we propose entirely new approaches, which overcome these issues. Our novel techniques will include a simultaneous treatment of the physics in all internal and external conductive layers and will for the first time use all available observations including auroral emission to go beyond considering magnetic fields only. EXO-OCEANS will systematically characterize the ocean properties on Europa and Ganymede including the ocean candidate Callisto. Characterizing the oceans on Ganymede, Europa and Callisto are at the heart of ESA’s Juice and NASA’s Europa Clipper missions. For Saturn’s moons Titan and Enceladus where currently existing techniques do not work, we will invent a new detection technique. In parallel we will use the Hubble Space Telescope to search and characterize aur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Dual Ligand-Enabled Palladium Catalysis: Unlocking Novel Reactivities and Selectivities in Aromatic C–H Activation'.

assistant: **Innovation**

The transition metal catalyzed activation of aromatic carbon-hydrogen (CH) bonds has enabled a variety of novel transformations that complement traditional approaches towards complex aromatic compounds. The vast majority of methods developed in this field relies on the use of directing groups, which coordinate the catalyst prior to the CH activation step to induce activity and selectivity. In contrast, nondirected methods have remained underdeveloped, since it has remained highly challenging to achieve reactivity and induce good selectivities in such processes. My research group has recently discovered a new design paradigm for palladium catalysts, which exhibit extraordinary activities and selectivities. Through the combined action of two complementary ligands these catalysts enable the activation of arenes without requiring a directing group or the use of an excess of the substrate. Here, I propose to initiate a broadly conceived research project aiming at three major goals: 1) The development of highly active palladium catalysts that can activate even the most challenging arene substrates. This goal will be pursued by building a broad ligand library and conducting systematic structure activity studies that are designed to deliver an in-depth mechanistic understanding. 2) The development of catalysts that enable high sterically controlled regioselectivities. This goal will be tackled using a mechanism-based design approach, aiming to minimize the influence of electronic effects and to suppress unintended directing effects. 3) The development of novel synthetic methods for late-stage functionalization. A particular focus will be on transformations that exhibit otherwise challenging regioselectivities and deliver attractive motifs for medicinal chemistry. Overall this p