RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'IARC International Fellowships Programme'.

assistant: **Innovation**

The IARC Fellowship Programme aims to promote international collaboration in those aspects of cancer research related to IARC's own programme by providing training at the Agency in Lyons, France, for postdoctoral scientists from low- to medium-resource countries who wish to pursue a career in cancer research.  Fellowships are awarded in the following areas of cancer research: epidemiology, biostatistics, environmental chemical carcinogenesis, cancer etiology and prevention, infection and cancer, molecular cell biology, molecular genetics, molecular pathology and mechanisms of carcinogenesis, with emphasis on interdisciplinary projects. Postdoctoral Fellows are selected from applicants from any country other than those classified as high-income economies by the World Bank. Candidates must have spent less than five years abroad (including doctoral studies) and have finished their doctoral degree within five years of the closing date for application or be in the final phase of completing their doctoral degree (M.D. or Ph.D.). They must provide evidence of their ability to return to their home country and keep working in cancer research. Applicants are expected to contact the Group(s) of their choice at IARC before application in order to interact closely to establish a proposed programme of mutual interest. These fellowships are for a period of 2 years, the extension for a second year being subject to satisfactory appraisal. Upon successful completion, a modest return grant may be awarded to help the candidate start up an independent research programme linked to IARC activities upon return to his/her home country.   The selection of postdoctoral Fellows is made by a Selection Committee composed of scientists of international reputation in the field of cancer research who a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanisms of precursor mRNA fate control' under Horizon Europe.

assistant: **Concept**

Messenger RNA (mRNA) is critical for transferring information from DNA to protein, a process that requires a series of tightly orchestrated steps. During these steps, mRNAs are classified as either functional or faulty, and directed towards biogenesis or degradation. This ensures the efficient and faithful expression of protein-coding genes. Yet, the mechanisms that decide the fate of mRNAs remain unclear. Prior work and our preliminary data show that RNA splicing plays a critical role in making this decision, by committing functional mRNAs towards packaging into ribonucleoprotein complexes (mRNPs) and directing faulty mRNAs towards degradation. Although recent studies have revealed individual aspects of RNA splicing, packaging, and decay, it remains unclear how these processes work together to distinguish functional from faulty mRNPs and determine their fate. Here, I propose to visualize key mRNP processing intermediates from human cells to advance our understanding of mRNA fate control toward biogenesis (aim 1) or decay (aim 2). Central to our efforts is the visualization of large and dynamic precursor mRNP complexes undergoing splicing and packaging (aim 1) or splicing and decay (aim 2) using state-of-the-art cryo-electron microscopy, tomography, and protein crosslinking. This leverages our expertise and preliminary data for the integrative study of endogenous protein-nucleic acid complexes. Our research will generate new hypotheses for how mRNP biogenesis and degradation are achieved, which we will probe in targeted in vitro and in vivo structure-function experiments, including by the super-resolution imaging of mRNAs in cells. This work will consolidate three areas of RNA biology – splicing, packaging, and decay – and promises groundbreaking insights into the mecha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Determining the mechanisms behind goblet cell dysfunction' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Goblet cells are specialized epithelial cells that secrete mucus and antimicrobial proteins which together form the gut mucus barrier. The mucus barrier protects the host from bacterial invasion and subsequent activation of an inflammatory response, while also providing food for the microbiome. Dysfunction of goblet cells and high penetrability of the mucus barrier are hallmarks of inflammatory bowel diseases (IBD). While the reasons for goblet cell dysfunction are unclear, it is thought that inflammation, host genetics (specifically mutations in autophagy genes) and environmental factors can affect their function. Yet despite their importance, the basic biology of goblet cells is not understood as they are part of a heterogeneous tissue. I developed a new mouse model that allows isolation of ribosomes specifically from goblet cells in vivo, thus revealing the translational response of goblet cells to various conditions. In preliminary studies we found that altering the autophagy process in vivo led to modification of the colonic mucus barrier, alteration of the microbiome and resistance to colitis. We also found that antibiotic treatment, an environmental factor which increases the risk for IBD, altered the mucus barrier and instigates gut inflammation in mice. Our goal is to mechanistically determine how inflammation, autophagy and antibiotics affect goblet cell function during health and IBD. We will 1) define goblet cell function during IBD development in vivo and test if goblet cells fail to regain proper function during remission, leading to relapse. We will also 2) use a novel mouse model of augmented autophagy to determine the role of autophagy in preserving goblet cell function during IBD. Lastly, 3) we will use germ-free mice to reveal the microbiome-dependent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Microsystems Network' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This project aims at:i) continuing to expand the activities of the European Network of Microsystems (MST) users and suppliers and;ii) establishing NEXUS as a legal, non-profit, Association.DESCRIPTION OF WORKThe first aim will be achieved through building on the success of the User-Supplier Clubs and their prime tasks of developing technology roadmaps, identifying new opportunities through market investigations and facilitating the process of technology transfer to maintain a European lead in this field of technology.The second aim will be achieved by setting-up the framework for the transition of this network of about 500 member organisations to a, subscription-based, legal entity. As an Association, NEXUS-2000 will expand its presence and influence on a global basis through NEXUSPAN (linking Eastern Europe) and through formal links and affiliations with non-European organisations in the USA, Japan and Taiwan amongst other countries with microsystems capabilities. This objective will establish NEXUS as a global network, centred in Europe.NEXUS-2000 has the infrastructure and prominence to fulfil the above objectives and continue to satisfy its over-riding objective of promoting the uptake of microsystems and microtechnologies by European organisations. In this context, NEXUS-2000 will establish new User-Supplier Clubs, publish technology roadmaps and an update of the market analysis report issued by NEXUS in 1998. This project also includes plans for promoting MST and disseminating information through conferences and related activities. This will be achieved through continuing the links NEXUS has established with other related, European, projects, national programmes and consultants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Effects of pulse events at different spatial and temporal scales on stream ecosystems' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The primary objective of the project is to investigate the effect of spatial and temporal scales on the ecosystem response to flow pulse events. Flooding and drying episodes influence ecosystem dynamics at multiple spatial and temporal scales. Ecosystem processes like nutrient cycles and carbon fluxes are differentially shaped at variable spatial scales by both flood events and droughts. Stream metabolism (primarily gross primary production and ecosystem respiration) will be used to evaluate ecosystem processes.Better understanding of flood and drought effects on stream and river ecosystem processes and how these processes are affected by the spatial and temporal scales will improve strategies for conservation and restoration as well as redefine and enhance the state of the science in stream and river ecology. With this background, I propose to study the effect of flow pulse events on stream metabolism at different spatial scales within one river system in the Swiss Alps. The project will be carried out at t he Swiss Federal Institute for Environmental Science and Technology (EAWAG, Switzerland), in the Department of Systems Analysis, Integrated Assessment and Modelling and the Department of Limnology.The submitted project fits in the general objectives and principles of the `Specific Programme: Structuring the European Research Area as it involves a more effective co-operation between the research disciplines (modelling and stream ecology), promotes further co-operation between research and environmental public agencies, reinforces the linkages between European researchers and research centres from associated countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'LABORATORY ASTROCHEMICAL SURFACE SCIENCE IN EUROPE' (LASSIE).

assistant: **Innovation**

Astronomical observations are revealing in ever increasing detail how our Universe works. Existing and planned European investment in sophisticated observational platforms approaches many billions of Euros. However, the observations that can be made on these telescopes would be little more than pretty pictures" were it not for the efforts of the experimental and theoretical laboratory astrophysics communities in collaboration with their astronomical colleagues in developing models of our Universe firmly grounded here on Earth. These models recognise the importance of chemical processes in the astronomical environment and the young science of Astrochemistry seeks to understand the rich variety of this chemistry in such a way as to make a significant contribution to us truly understanding the evolution of the modern day Universe. The LASSIE (Laboratory Astrochemical Surface Science in Europe) Initial Training Network seeks to address the key issue of the interaction of the astronomical gas phase with the dust that pervades the Universe. The gas-grain interaction, as it is know, has been recognised by astronomers as crucial in promoting chemistry. The LASSIE ITN brings together the leading European players in experimental and computational surface and solid state astrochemistry, astronomers seeking to understand the detailed role of chemical species in our modern Universe, industrial partners engaged in the development of relevant laboratory instrumentation and experts in public engagement. Through this combination LASSIE will develop capacity in astrochemistry in Europe, produce researchers equipped with a range of specialist and generic skills necessary to engage in a wide range knowledge-based careers and to reach out to all aspects of European society to deliver a posi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Co-designing Holistic Forest-based Policy Pathways for Climate Change Mitigation' (ForestPaths).

assistant: **Innovation**

The EU target to significantly reduce its emissions by 2030 and become climate neutral by 2050 requires new mitigation measures within all sectors. Clear policy pathways are needed that outline alternative trajectories for European forests and the forest-based sector towards a climate-neutral and resilient society and economy. ForestPaths will co-design, quantify and evaluate holistic forest-based policy pathways to optimize the contribution of forests and the forest-based sector to climate change mitigation, while considering the need to adapt forests to climate change, conserve biodiversity and sustain forest ecosystem services provisioning. ForestPaths goes beyond the state-of-the-art by finding feasible Climate & Biodiversity-Smart (CBS) options across Europe, suggesting effective mitigation actions, and analysing their co-benefits and trade-offs with biodiversity and ecosystem services. ForestPaths engages with policymakers, forest practitioners, regional and national authorities, forest-based sector, certification bodies, researchers, and civil society in a co-design process to develop policy pathways and CBS options and maximize their practical usability, transparency, and trustworthiness. Openly available through an online policy support platform, pathways will be quantified based on a next-generation assessment framework of models, tools, and data. This framework will consider forest growth, climate change risks, as well as interactions between forests and the forest-based sector and economic system, supported by state-of-the art monitoring of forest disturbances, composition, and structure. The multidisciplinary consortium consists of research institutes, universities, and SMEs from across Europe, with leading expertise on climate, energy and biodiversity poli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'effiCient mineral processing and Hydrometallurgical RecOvery of by-product Metals from low-grade metal contaIning seCondary raw materials' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Europe is faced with the challenge of sustaining a secure supply of by-product metals, which play a fundamental role in the competitiveness of the manufacturing sector and innovations in high-tech sectors. To loosen the growth restrictions imposed by the inflexible supply from primary mining, alternative sources for these metals must be explored. At the same time a wealth of metals is entrapped within the vast amounts of secondary resources still being landfilled or used in applications where their intrinsic value is not fully utilized. To unlock the potential of these resources, a radically new approach to metal recovery must be deployed. Crucial factor within this new value chain is the zero-waste approach, which captures not only the contained metals but also valorises the residual matrix (often >95% of the bulk material). Such an approach requires the development of innovative, highly selective metal recovery technologies that fully capture the metal-value without impairing the properties of the residual matrix material for valorisation. CHROMIC aims to develop such new recovery processes for critical (Cr, Nb) and economically valuable (Mo, V) by-product metals from secondary resources, based on the smart integration of enhanced pre-treatment, selective alkaline leaching and highly selective metal recovery across the value chain. An overarching assessment of the related economic, environmental and health and safety aspects will be carried out in an iterative way to ensure that the developed technologies meet the requirements of the circular economy whilst being in line with current market demand. The technology will be developed for two models streams (stainless steel slags and ferrochrome slags) with the potential of replication to numerous industrial residues acro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multi-Gigabit European Research and Education Network and Associated Services' in the context of a Seventh Framework call.

assistant: **Objectives**

This proposal details activities that will ensure the continued enhancement and ongoing operation of the leading-edge GÉANT network, supporting a range of network and added-value services, targeted at users across the GÉANT service area.In the area of multi-domain network service operation, GN3plus plans to deliver fast, efficient provisioning of advanced services, develop operational support across management domains, and improve security to ensure service integrity and protect network resources. These initiatives will be complemented by the development of application services in a federated environment – such as mobile and wireless roaming – supported by safe and secure Authentication and Authorisation Infrastructure.Networking Activities will provide management and support for all GN3plus activities through communication, promotion, international liaison and business development. Emphasis will be placed on supporting and encouraging service take-up among users by working closely with NRENs. GÉANT will increase digital inclusion through closer collaboration between NRENs, exchange of staff and specialist expertise, as well as by seeking synergies between public administrations and the GN3plus partners using their vast, shared knowledge base.Joint Research Activities will be targeted at providing critical analyses of future network and application technologies, with a view to future deployment of emerging technologies within and outside the GÉANT community.The governance model aims to increase effectiveness and user influence. The GN3plus Partners' Assembly will deal with overall policy and an Executive Board will oversee its implementation. An International User Advisory Committee and External Advisory Committee will ensure users' views and senior industry and service
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sustained, Efficient Production of Required Information and Services within Europe is our only justification', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The overall objective of the project is to discern and enable methods of increasing, improving and coordinating production of European scale Operational Ocean Forecasting Products and Services. This will be achieved by reviewing and then ensuring that, as far as possible, the findings and experience gained from the so-called Operational Forecasting Cluster of Projects funded under MAST III and FP-5, and other relevant sources, are pulled through into sustained, efficient operational oceanographic services. Recommendations for the future structure and functionalities of an integrated initial European coastal ocean observing and forecasting system will be made and a design plan to implement this will be prepared. Care will be taken to ensure that proposals are compatible with the wider implementation of GMES, in particular to ensure interoperability with similar initiatives outside the marine theme.