RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'INDI, world’s first 100% dairy free, soy-free infant-formula.'.

assistant: **Concept**

All paediatric associations worldwide recommend breast feeding as the Gold Standard for the first month of life. If, for anyreason, this is not possible, the next best choice is Infant Formula (IF) based on cow’s milk. Some infants are not fed withIFs due to allergies, certain metabolic disorders, or parental decision to follow a vegan diet. For these infants, the choice issoy-based IF. Other consumer products, such as “soy milk”, “almond milk”, are not suitable for feeding infants, and are notconsidered a substitute for breast milk or IF. These foods can severely affect the growth and development, and may lead toserious conditions of malnutrition.Approximately 2.5% of all the children are allergic to cow's milk. Allergy to cow’s milk is indeed the most common foodallergy in infants and young children. 65% or more of the total human population are lactose intolerant (main carbohydrate inmilk). Plus, as many as 10-35% of babies with cow's milk allergy are also allergic to soy.Our solution is the world’s first 100% vegan dairy and soy free infant, toddlers and children formula that provides a completesource of nutrition. INDI meets the Gold Standard of breast milk composition and performance compliance of baby’s formulawithout the harmful effects, plus the ability of being scalable, available, affordable, and patentable.INDI is a patented breast milk nutritional equivalent and can be used as the sole food source of an infant. It is composed with2 plants (which makes it 100% vegan), contains full amino and fatty acid profiles, required for a proper nutrition and bodyfunction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Revealing the immune tumor microenvironment (iTME) in melanoma by multiplexed imaging' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Immunotherapies targeting immune regulators are revolutionizing cancer treatment, most prominently in melanoma, but only for a subset of patients. While it is known that the immune tumor microenvironment (iTME) plays a vital role in this process, there is limited understanding on how distinct tumor, immune and stroma cells interact as a system to collectively define progression and response to treatment, and there is no biomarker to predict patient response. Tumors are spatially organized ecosystems that are comprised of distinct cell types, each of which can assume a variety of phenotypes defined by coexpression of multiple proteins. To underscore this complexity, and move beyond single cells to multicellular interactions, it is essential to interrogate cellular expression patterns within their native context in the tissue.We have recently pioneered MIBI-TOF (Multiplexed Ion Beam Imaging by Time of Flight), a novel platform that enables simultaneous imaging of forty proteins within intact tissue sections at subcellular resolution. We propose to (1) Use MIBI-TOF to chart the iTME in dozens of clinical samples from melanoma patients and delineate its function in response to different immunotherapies. (2) Profile murine melanoma tumors to elucidate genetic and temporal mechanisms that drive iTME organization in vivo. (3) Develop new experimental tools for tracing and barcoding thousands of cells to decouple the effects of tumor genetics and the immune microenvironment on tumor organization and clonal dynamics. (4) Develop machine-learning-based algorithms to analyze this novel data and facilitate accessibility of the scientific community to high-dimensional imaging to study human malignancies.This proposal applies state-of-the-art imaging technology and computation to unr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'How has the rapid scale up of malaria control in Africa impacted vector competence?'.

assistant: **Innovation**

The malaria parasite Plasmodium falciparum is responsible for more than 200 million cases and 400.000 deaths each year, with over 90% of cases occurring in Africa. The parasite is reliant upon Anopheline mosquitoes for transmission and insecticide treated bed nets targeting these mosquitoes represent the single most efficacious way to reduce case numbers and hence deaths. However, due to the use of pyrethroid insecticides on all distributed insecticide treated bed nets, insecticide resistance now threatens the impact of these interventions. Analogously, deaths from active malaria cases have been decreasing through the successful use of drug therapy; however, resistance to every class of front-line drug has now been described. Incredibly, we simply do not know the impact of current vector control tools on parasite development nor the impact of drug resistance on development within the mosquito vector, despite fine scale characterisation in the erythrocytic stages. With the stalling of progress in malaria elimination and the addition of new chemistries to insecticide treated bed nets, it is time that we invested in understanding precisely how our current vector control tools affect the parasite in order to avoid catastrophic failure of malaria control. To this end, I propose to: (i) Determine the impact of insecticide use on parasite development in the contexts of species replacement, insecticide resistance and insecticide exposure; (ii) Elucidate the changes due to parasite drug resistance on mosquito-stage development; (iii) Ascertain genetic interplay between mosquito immunity and response to insecticides to identify new targets that negatively affect insecticide resistance and parasite development. The results generated from this multidisciplinary proposal will redefi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ReCoNnect: Research Communication for active learning', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Researchers worldwide are struggling nowadays to solve some of the critical issues which pose a threat to our future life on Earth. While everyone heard about the climate change, smart cities, freshwater and ocean pollution, soil degradation which conduct to poor quality of food, or cancer, but most of the time only with respect to disasters or an uncertain future, the researchers are actively involved into identifying practical solutions for all these threats, developing devices and systems to monitor, control and diminish their effect, and to cure people and Earth. These missions will have the chance of becoming effective only by ReCoNnect-ing the researchers to the society, by developing a mutual respect and understanding one needs a will to listen, to be open to the new and to explore. As such, we propose the adoption of a special life strategy, that of continuous and active learning, in which all those involved, scientists, communicators or the general public, are active learners interacting with each other.The consortium is made up from 5 research institutes, the largest and most prestigious in the country, 4 universities, with high scientific expertise but also including journalism faculties and one public scientific body, that have been participating in previous research outreach events and coordinate some of the largest STEM educational networks (teachers and pupils) derived from the European programmes.  By organization of 20 NIGHT events yearly, also in rural areas, and a strong involvement of researchers at school along the 2 years project implementation, we are confident in the strengthening of the science communication and educational programs already developed, increasing, meanwhile, the number of researchers involved in outreach activities. These allow u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deaf mobilities across international borders: Visualising intersectionality and translanguaging' to be submitted under Horizon 2020.

assistant: **Abstract**

Deaf signers’ international mobilities are rapidly increasing. These mobilities are unique in a number of respects: while being biologically deaf leads to certain limitations and to discrimination and inequalities, being skilled in visual language also creates possibilities and opportunities for communication across national and linguistic borders. There are two main research questions in the project. First, within contexts of international deaf spaces, how does the status of being deaf intersect with other statuses, particularly ethnicity, nationality, education, religion and gender, and which meaningful connections or accumulated inequalities occur? Second, how do deaf signers in these contexts practice and experience translanguaging, by making strategical use of multiple languages and language modalities, and International Sign? Four subprojects will focus on structurally different kinds of international deaf mobilities: (1) forced migration, (2) labour migration, (3) professional mobility, and (4) tourist mobility. The research team will be all-deaf as to maximise access to various sign languages, access to distinct deaf networks, and insights into deaf ways of living. This is a unique endeavour as most deaf-related research is hearing-led. The methodology will be ethnographic but neither logocentric nor audiocentric as visual methods (photography, video, mapping, and the production of four ethnographic documentaries) will be heavily employed, doing justice to the visual nature of sign language communication. By scrutinizing and bridging the concepts of intersectionality and translanguaging, this study will contribute to the study of growing complexity in diversity and mobility; the production/delimitation of social spaces particularly through language practices, st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Emotional Machines: The Technological Transformation of Intimacy in Japan' under Horizon 2020.

assistant: **Concept**

EMTECH analyzes the relationship between aesthetic works on human-robot interaction in Japan and cutting-edge advances in robotics and artificial intelligence. Its central hypothesis argues that a tradition of literary, artistic, and other media forms of cultural production on human-robot relationships particular to Japan is currently being built into emotionally-intelligent companion robots with the ability to understand, record, and elicit emotions in its users, consequently expanding the capacities for humans to create affective bonds with machines and transforming structures of intimacy that sustain traditional social institutions. In its most ambitious claim, EMTECH argues that this cultural tradition has played a primary role in inspiring the recently-emerging mass production of domestic robots with technology that can register and record facial expressions, heart rate, skin conductance, and other signs of affect not consciously recognized by humans, thus generating new kinds of scientific data on human affect that fundamentally challenges previous understandings of emotion. Through the textual analysis of literary work on robot imaginaries and ethnographic fieldwork on human-robot interaction in homes, palliative care centers, and engineering laboratories, EMTECH’s purpose is to collect qualitative data on new technologies of emotion management in order to advance literary and cultural theory’s contributions to the affective sciences, as well as to inform public discussions on issues of data collection, privacy, and other ethical concerns raised by the adoption of emotionally-intelligent robots in the home. Leveraging research in the humanities to critique emotional models employed by robotics engineers and designers, and implementing novel research methods such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enterprises intangible Risks Management via Economic models based on simulatioN of modErn cyber-aTtacks' (HERMENEUT) targeting Horizon 2020.

assistant: **Abstract**

IT security and risk management often ignore or underestimate the human factor (psychological, behavioural, societal, organisational and economic aspects) in the identification of cyber-risks, their quantitative economic impact and the costs of countermeasures.  Cyber-attacks can  harm  intangible  assets  like  reputation,  IPR,  expertise,  and  know-how. And  there  is  severe  imbalance  between  the  efficiency  of attacks  and  inadequate defences, due in part to the lack of quantitative information for decision makers to prioritise security investments. To foster a culture of risk management by an individual organisation or a complete sector, HERMENEUT answers: What is the real fallout of a data compromise and the long-run consequences on associated assets? What are the losses for intangible assets? Do other type of attacks (beyond data breach) severely impact intangible and tangible assets?  HERMENEUT  assesses vulnerabilities  of  organisations  and corresponding tangible   and  intangible   assets   at  risk,  taking  into  account   the   business   plans   of  the   attacker,  the  commoditisation level of the target organisations, the exposure of the target and including human factors as well as estimating the likelihood that a potential cyber-attack exploits identified vulnerabilities. HERMENEUT’s   cyber-security  cost-benefit approach  combines  integrated  assessment  of vulnerabilities  and  their  likelihoods  with  an  innovative  macro-  and  micro-economic  model  for  intangible costs, delivering a quantitative estimation of the risks for an organisation or a business sector and investment guidelines  for  mitigation  measures.  11 partners from 6 countries deliver an innovative methodology and advanced macro- and micro-economic models and make it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Knowledge Hub and Policy Testbed for Critical Infrastructure Protection' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The main goal of EU-CIP is to establish a novel pan European knowledge network for Resilient Infrastructures, which will enable policy makers to shape and produce data-driven evidence-based policies, while boosting the innovation capacity of Critical Infrastructures (CI) operators, authorities, and innovators (including SMEs). In this direction, the partners have already established the European Cluster for Securing Critical infrastructures (ECSCI), which brings together 22 projects that collaborate in CI Resilience. EU-CIP will leverage the capacity, organization, community, and achievements of the ECSCI cluster towards establishing an EU-wide knowledge network with advanced analytical and innovation support capabilities.The project’s analytics capabilities will fulfil the reporting requirements listed in the call in terms of the number and the (semestrial) frequency of the reports. To facilitate information collection and analysis, the project will establish a FAIR data observatory of research projects, research outcomes, technologies, standards, and policies. Along with analytical capabilities for evidence based policies, the project will organize and offer a rich set of innovation support services to EU projects and other innovators in CI security and resilience. These services will include training, support in business planning and access to finance, as well as support in the validation, standardization, and certification of novel solutions.The projects outcomes will be integrated and made available through a Knowledge Hub, which will provide a singly entry point to the EU-CIP results. EU-CIP will build a vibrant ecosystem of over 1000 stakeholders around this knowledge-hub. To animate and grow the project’s community, EU-CIP will execute an ambitious set of dissem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sperm chromatin and the evolution of chromatin architecture at regulatory regions in animal genomes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The genome of eukaryotic cells is packaged into chromatin. Recent technological advances have allowed the profiling of chromatin on a genome-wide scale in a diversity of living species. We are now faced with an excellent opportunity to study chromatin function and evolution in a way that was not possible before. Here, I propose to study the mechanisms of nucleosome retention in human sperm and the role and evolution of chromatin architecture at regulatory elements of animal genomes.  In human sperm, most of the genome is packaged by protamines and not by histones. The 4% of the human genome that remains packaged in nucleosomes tends to contain gene promoters and developmental regulatory genes. However, there is no mechanism to explain why nucleosomes are retained at these locations. To this end, I will test three possible mechanisms of nucleosome retention in human sperm. This information will help us understand the mechanisms that may affect epigenetic inheritance. As a second aspect of this project, I propose to study the interplay between chromatin structure and regulatory evolution in animal genomes. Nucleosome positions have been mapped throughout five entire animal genomes; human, mouse, Japanese killifish (Oryzias latipes), Caenorhabditis elegans and Drosophila melanogaster.  I propose to use this data and the intrinsic affinity for nucleosomes predicted from in vitro nucleosome reconstitution experiments to study the role of nucleosome positioning in the evolution of promoters and distal enhancers in metazoans.  The grant will be used for the transition from a post-doctoral to an independent research position and will contribute to my integration in a major scientific hub in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Inadequate migration of Leishmania-infected macrophages – the driver of parasite dissemination?' (LeishMOM) targeting Horizon Europe.

assistant: **Abstract**

Leishmania parasites, a threat to 350 million people worldwide, are transmitted by sand flies and reside predominantly intracellularly in macrophages. Leishmania species can remain local (cutaneous leishmaniasis) or spread throughout the tissue and body (mucocutaneous/visceral leishmaniasis). This is the difference between a mild illness or a deadly disease, and the fundamental mechanisms behind these different clinical manifestations are largely unknown. As Leishmania parasites seem immobile following their delivery into the skin and are rapidly phagocytosed, it has been hypothesised that dissemination is driven by host cell migration in a species-dependent manner. Specifically, previous studies showed that Leishmania species causing visceral infections typically enhance macrophage motility, while species linked to cutaneous lesions slow down infected macrophages. However, few studies have directly compared migration of parasitised macrophages across multiple Leishmania species and it remains unclear which host migration pathways Leishmania manipulates. We want to test the hypothesis that different Leishmania species alter integrin-dependent and –independent macrophage migration modes in distinct ways, to control dissemination through the dermis and across endothelial barriers. Using human skin equivalents, cell deformability assays, and two- and three-dimensional migration assays, we will measure changes in migration dynamics of Leishmania-infected macrophages. Additionally, we will perform drug inhibitor and CRISPR screens, targeting macrophage genes, to identify host pathways essential for migration of parasitised macrophages. To dissect species-related differences, this study will use species causing visceral, mucocutaneous, and cutaneous leishmaniasis.  The result