RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Palladium catalyzed C(sp3)‒H late-stage diversification of biologically active molecules' in the context of a Horizon 2020 call.

assistant: **Objectives**

Aliphatic amines are central to the function of many biologically active molecules as evidenced by their prevalence in a large number of pharmaceutical agents. The groups appended to these nitrogen atoms are crucial in determining the physical properties of the amine and are linked to how well it interacts with a biological target. Despite the apparent simplicity of the aliphatic amine motif, the number of general methods that allow their late-stage functionalization directly on the bioactive compound is surprisingly limited, and so the development of directed catalytic methods remains an important challenge. Metal catalysed C–H activation represents a versatile tool for late-stage functionalization. It mostly relies on directing functional groups to functionalize C–H bonds. Recently, Professor Gaunt at the University of Cambridge has uncovered a new C–H activation mode that enables the conversion of hindered amines into β-lactams and aziridines. The first objective of this proposal aims to directly apply the transformations developed by Gaunt, e.g. carbonylation, aziridination and acetoxylation reactions, to a precise class of drugs that contain the secondary amine motif as central function, i.e. β-adrenergic drugs. The use of the oxidative Pd(II)/(IV) catalytic cycle will then allow the development of a novel fluorination. The second objective relies on a new methodological concept, which seeks to merge palladium catalysis with radical chemistry, opening a route to develop novel perfluoroalkylation, amination and methylation reactions via a new Pd (II)/(III)/(IV) catalytic cycle. Finally, the third aim will be to apply all the methods developed to four important anticancer drugs, in collaboration with the new AstraZeneca oncology unit in Cambridge, to prepare novel an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Swarm Robotics Construction System' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This proposal details an investigation into the development of control software for swarms of robots tasked with building structures. The behavior of the individual robots in this work will be fully autonomous and will be based on the nest building behavior of social insects. It is of interest to investigate whether the building behavior of social insects can be transferred to and implemented in a swarm of robots since the social insect behavior has been shown to be parallel, robust, and scalable.I outline in this proposal the second milestone of my ambitious research project that I have devised to investigate how swarm robotics can be applied to construction. I completed the first milestone of this research project during my doctoral studies, where I implemented and validated a swarm robotics construction system using both hardware and simulation.I have organized the second milestone of my research project into four work packages. In these work packages, I will develop, implement, and validate control software for a swarm of robots, which must perform a construction task. These work packages use a combination of the simulation and hardware tools that I developed during my doctoral studies to efficiently and accurately answer a number of open research questions. I have designed these work packages to be completed at IRIDIA where I have access to world-class facilities such as a computer cluster with more than 1000 CPUs for running simulations and a state-of-the-art arena and tracking setup for running hardware experiments.I believe that by undertaking the second milestone of this project at IRIDIA under the supervision of Prof. Marco Dorigo, I will be able to successfully establish myself as an independent researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'HUMANITIES ROCK! Humanities and Social Sciences on stage in Ljubljana'.

assistant: **Concept**

The objective of “HUMANITIES ROCK!” is to bring researchers of Humanities and Social Sciences closer to the public at large, enhancing their role in the mainstream society, and to present research as an exciting and attractive endeavour. The Faculty of Arts, University of Ljubljana, which celebrates 90 years of its existence this year, is the most important unit of research in the Humanities and Social Sciences in Slovenia. It has organised many public events and activities for support of public understanding of research in Humanities and Social Sciences (e.g., the so-called cultural days, occasional events related to public holidays and festivities, etc.). Despite well-established communication with the public in the past, the humanities are becoming marginalized, if not neglected, not only in the more and more commercialized public space, but as well within the research area. This recent marginalization is partly a consequence of the misperception of the researchers’ professional life in the field of humanities. With the main event on the 25th of September in 2009, the organizers are aiming to improve the perception and reputation of research in public. The event will carefully target the most vital and important parts of the public: children and youth, families and ageing people. The preceding awareness campaign will comprise the public tender for posters and establishment of personal contacts with media representatives. The researchers will be the stars of the night, but at the same time they will be presented on stage as ordinary people. The “HUMANITIES ROCK!” will offer many different and attractive events and activities in Ljubljana for everyone, children and schoolchildren, families and adults. The proposed activities are various presentations, excursions and sh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The search for Earth-like extra-solar planets' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This fellowship proposal aims at the development of Dr. Bruno Chazelas's young career in the direction of instrumentation in astrophysics. The fellow, has a background in optical instrumentation applied  to astrophysics. The objectives of this project are to expand his experience in new instrumentation domains, to develop his research background in astrophysics, and to acquire the experience of practical astronomical observation. The research experience of the applicant, was centered on the direct detection and spectroscopy of the atmosphere of extra-solar planets via nulling interferometry (DARWIN, ESA mission). The subject of this project is to make decisive technological advances in the radial velocity detection technique (most productive current detection method) that will permit to discover the firsts earth-like planets.  The applicant will work on these subjects at the Geneva Observatory, a top level research group in extra-solar planet detection and characterization. This team thanks to its access to the most advanced radial velocities instruments (CORALIE, HARPS) and their large experience in that field will offer the applicant a perfect environment to develop his competencies. The fellow will also participate to the ongoing research programs via his observational work.   Two of the known limiting factors of the current radial velocity instruments are the calibration and the light feeding into the spectrometer. These two issues will be addressed during this project, in order to obtain the required 10 cm.s¯¹ precision that is needed to detect earth like planets (1 earth mass in the habitable zone i.e., 1 au for a sun-like star).  In order to enlarge the fellow experience in instrumentation he will participate to the PRIMA astrometric instrument commissioning and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Role of Parathyroid Hormone related Protein (PTHrP) in endochondral bone development: Application as a possible marker for skeletal anomalies in fish'.

assistant: **Concept**

The high incidence of larvae skeletal deformities is a significant problem in European marine aquaculture. This problem has a serious impact on the industry's productivity, on product quality and on animal welfare. The factors, which may cause skeletal anomalies in fish are largely unstudied, although in tetrapods there is ample evidence that PTHrP plays a significant role in both normal and abnormal development and growth of the skeleton. Preliminary studies carried out by the CME group indicate that PTHrP may be implicated in skeletal deformities, which arise as a consequence of altered chondrogenesis and calcification.Thus, the fundamental scientific objective of this project is to investigate the importance of the unique hypercalcemic factor identified in fish, PTHrP, in endochondral bone development and its application as a possible marker for skeletal anomalies in fish. This will be achieved through the application of recombinant DNA and gene transfer technology as a tool for the induction of PTHrP gene over expression in fish embryos. The present project programme will therefore aim to establish unequivocally the role of PTHrP in chondrogenesis and skeletal development and link this to skeletal abnormalities. Several objectives have been identified which will contribute to the overall achievement of the aim.Firstly, obtention of PTHrP expression construct and its microinjection into fertilized fish eggs; Secondly, assessment the ectopic expression of PTHrP in notochord cells of fish embryos and finally, evaluation the influence of PTHrP in the development of axial skeleton. Moreover, additional objectives of this research proposal are to promote the scientific development of the applicant and transfer the technology and knowledge acquired at the host institute du
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Computational Analysis of Everyday Soundscapes'.

assistant: **Objectives**

Sounds carry a large amount of information about our everyday environment and physical events that take place in it. For example, when a car is passing by, one can perceive the approximate size and speed of the car. Sound can easily and unobtrusively be captured e.g. by mobile phones and transmitted further – for example, tens of hours of audio is uploaded to the internet every minute e.g. in the form of YouTube videos. However, today's technology is not able to recognize individual sound sources in realistic soundscapes, where multiple sounds are present, often simultaneously, and distorted by the environment.The ground-breaking objective of EVERYSOUND is to develop computational methods which will automatically provide high-level descriptions of environmental sounds in realistic everyday soundscapes such as street, park, home, etc. This requires developing several novel methods, including joint source separation and robust pattern classification algorithms to reliably recognize multiple overlapping sounds, and a hierarchical multilayer taxonomy to accurately categorize everyday sounds. The methods are based on the applicant's internationally recognized and awarded expertise on source separation and robust pattern recognition in speech and music processing, which will allow now tackling the new and challenging research area of everyday sound recognition.The results of EVERYSOUND will enable searching for multimedia based on its audio content, which is not possible with today's technology. It will allow mobile devices, robots, and intelligent monitoring systems to recognize activities in their environments using acoustic information. Producing automatically descriptions of vast quantities of audio will give new tools for geographical, social, cultural, and biological st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Framework of key enabling technologies for safe and autonomous drones’ applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Drones can perform air operations that manned aircrafts struggle with, and their use brings significant economic savings and environmental benefits whilst reducing the risk to human life. Drone-based service and product innovation, as driven by increased levels of connectivity and automation, is limited by the growing dependence on poorly interoperable proprietary technologies and the risks posed to people, to other vehicles and to property. SESAR JU identified that issue has a high impact on European innovation, which demands R&D investments and incentives for the convergence of shared technologies and markets as a remedy. Actions creating globally harmonized, commercially exploitable yet widely accessible R&D ecosystems should be publicly performed. The COMP4DRONES project complements SESAR JU efforts with a particular focus on safe software and hardware drone architectures. COMP4DRONES will bear a holistically designed ecosystem ranging from application to electronic components, realized as a tightly integrated multi-vendor and compositional drone embedded architecture solution and a tool chain complementing the compositional architecture principles. The ecosystem aims at supporting (1) efficient customization and incremental assurance of drone embedded platforms, (2) safe autonomous decision making concerning individual or cooperative missions, (3) trustworthy drone-to-drone and drone-to-ground communications even in presence of malicious attackers and under the intrinsic platform constraints, and (4) agile and cost-effective compositional design and assurance of drone modules and systems. COMP4DRONES will also build an open sustainable ecosystem around public, royalty-free and goal-driven software platform standards that will ease the development of new drone funct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'use of multiscale modElling to Minimize coke ProducTion during the methanol-to- HYdrocarbon process'.

assistant: **Innovation**

The methanol-to-hydrocarbon (MTH) process is a versatile catalytic process that are gradually playing a more important role in the economy. However, an important factor that is inhibiting the profitability of MTH is accumulation of coke in the pores of the catalyst during operations. To reduce or eliminate the coke formation during MTH operations, it is necessary to have a detailed mechanistic insight into its cause of formation. In this proposal, I will achieve this insight through a computational modelling strategy. I will study the mechanism of the MTH process at various time- and length scales, using various computational methodologies. I will use computational fluid dynamics (CFD) to study the fluid flow at the reactor scale and the diffusion in the macropores. I will use kinetic Monte Carlo (kMC) and molecular dynamics (MD) to study the diffusion in the meso- and micropores. Finally, I will use density functional theory (DFT) to study the reactions at the active sites. The processes studied at the various length scales will be coupled together through a multiscale methodology. Multiscale modelling has steadily evolved over the past decade, but the concept is still at the proof-of-principle stage where the methodology has been demonstrated for simple test systems such as CO oxidation. The methodologies that will provide data to the multiscale simulation, CFD, kMC, MD, and DFT have all reached a high level of maturity. Now is the right moment to use a multiscale methodology to couple these methodologies together and solve the problem of coke formation in the MTH process. The potential outcomes are the following: 1) an understanding of how coke is formed in the MTH process; 2) a larger acceptance in the catalysis community to use multiscale modelling in the design of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Bottom-up reconstitution of a biomimetic bioartificial liver'.

assistant: **Objectives**

The liver, by way of its central role in both endogenous and exogenous metabolism, is one of the most well-studied organs in the human body.Hepatic tissue and its derivatives have a wide range of in-vivo and in-vitro applications from whole organ or partial lobe transplant, bioartificial ex-vivo devices, treatment of metabolic disorders to toxicology, drug metabolism and tissue regeneration. On the one hand, suitable donor livers for solid organ transplant are in short supply, while chronic liver diseases are on the increase both in Europe and world-wide. On the other hand, in-vitro and ex-vivo technologies for recapitulating liver function still fall short of reliability, consistency and predictivity, precluding many commercial applications. There is a dire need for innovative and reproducible methods for developing functional bioartificial livers or portions of liver which can be easily transplanted or reliably integrated into extracorporeal devices, essential for treating acute liver failure and other metabolic liver disorders. To avoid the risks and complications associated with animal/human matrices, yet furnish a reliable and reproducible 3D microarchitecture capable of maintaining the detoxification and metabolic functions of healthy human liver, our aim is to fabricate a novel hepatic lobuli ECM replica seeded with stable human hepatocytes and endothelial cells using the human liver as a design template through a bottom up approach. These cell-containing bioartificial constructs will be developed and characterized in vitro to assess metabolic function, protein production and angiogenic potential. They will then be implanted in animal models through minimally invasive techniques as a solid organ transplant alternative to recombinant Factor VIII-based therapy for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multimodal fMRI/EEG/MEG study of large-scale functional integration', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Any cognitive function is associated with a brain process that can be investigated by studying the neural networks recruited. These networks are characterized spatially and temporally using complementary neuroimaging measures, namely functional Magnetic Re sonance Imaging (fMRI), Electroencephalography (EEG) and Magnetoencephalography (MEG). However, the full and dynamical quantification of brain processes still requires a common and biologically plausible model to explain both the hemodynamic and electromag netic responses. Moreover, conjoint analyses need to be developed in order to identify the modelled dynamical systems and to perform statistical inference on the brain processes of interest. This constitutes an outstanding and multidisciplinary challenge f or the whole neuroscience and neuroimaging community. My project is to conceive and provide a novel cross-modal framework for assessing large-scale functional integration (functional brain connectivity). This includes - providing a common generative model of fMRI and EEG/MEG signals; - developing methods for the identification of this dynamical causal model and the conjoint analysis of multimodal data; - evaluating those approaches in the context of numerical and real experiments; - disseminating the method s and results by means of international publications and the release of validated routines. I will rely upon my previous experience in Bayesian inference and data fusion. I also expect to benefit from the rich interdisciplinary environment of the Functiona l Imaging Laboratory (FIL) and the associated Institute of Cognitive Neuroscience (ICN) in London. This project should have a profound impact on the characterization of brain dynamics, especially for a better understanding of context-dependent strategies l ea