RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An empire of 2000 cities: urban networks and economic integration in the Roman empire' (EMPIREOF2000CITIES) targeting Seventh Framework.

assistant: **Abstract**

The central aims of this project are to establish the shapes of the various urban hierarchies existing in the provinces of the Roman empire and (especially) to use the quantitative properties of these hierarchies to shed new light on levels of economic integration. Should we conceptualize the urban system of the Roman world as a collection of cellular ‘modules’ which were only loosely connected by the imposition of a rudimentary administrative superstructure and by resource flows of limited significance? Or did the creation of an overarching empire favour the emergence of an economically well-integrated urban network or at least the growth of certain ‘nodal points’ which helped to tie the empire together by mediating resource flows between regions? Key topics to be explored include the physical size of cities, the overall shape of regional urban hierarchies, the role of harbour cities in connecting various parts of the empire, and the economic implications of the emergence and existence of large provincial capitals and other ‘primate cities’.Building on spatial and economic theories from various disciplines, the project starts from the working hypothesis that the urban system of the Roman empire possessed a number of unique features which set it apart from that of the various urban system existing in the same geographical area during the early-modern period. While some of these features (such as the size of Rome) can plausibly be attributed to the fact that the Roman empire was much larger than the empires and emerging nation states of early-modern times, the project aims to demonstrate that the specific configuration of regional urban hierarchies in the Roman world also reflects levels of economic integration which fell dramatically short of those achieved in various p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developing biological control of greenhouse pests with simulation models' (1998-2002).

assistant: **Concept**

Plant-herbivore-natural enemies relationships will be simulated in order to address specific questions related to the sustainable management of greenhouse crops. New methods for biological control of pests and selection of natural enemies are expected
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'History of the Tocharian Texts of the Pelliot Collection' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

HisTochText addresses written Buddhist culture of the northern Silk Road in an innovative and path-breaking way, by going beyond the frontier of disciplines which have been cultivated separately: philology, digital humanities and in-depth analysis of materials, edition of Tocharian texts and comparative Buddhist literature, Sanskrit poetics and narratology, texts and social contexts.The flourishing Buddhist culture of the northern Silk Road during the 1st millennium CE in the Tarim Basin in present-day Xinjiang (NW China) is known by archaeological findings, artifacts and manuscripts in various languages. Since Buddhism was introduced from India, Sanskrit was the dominant religious language. By contrast, Tocharian belongs to the few local languages that are known to us thanks to Buddhist written culture. The two closely related Tocharian languages (Tocharian A and Tocharian B) were deciphered in 1908 on the basis of manuscripts discovered at the beginning of the past century in Buddhist sites of this region, together with Sanskrit manuscripts. The collection of the Bibliothèque nationale de France issued from the Pelliot expedition is a major collection of Tocharian manuscripts, counting around 2,000 fragments, second only to the Berlin collection, but in comparison hardly investigated, despite its containing numerous unique masterpieces and the broadest cross-section of manuscript and document styles and types. Only one fourth has been edited, mostly in a provisional manner, without translation nor commentary. Many texts of the Pelliot collection, literary and non-literary, are of the utmost importance because they have no match in any other collection of Tocharian manuscripts, nor in Buddhist corpora in other languages. As most Pelliot manuscripts in Sanskrit and in T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Effectiveness of Central Bank Communication' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This research project examines and compares the consequences of European Central Bank and Federal Reserve’s decisions and announcements on the whole distribution of financial market expectations about future monetary policy moves. The value added of this study is two-fold. First, we contribute to the rapidly expanding literature on central bank communication by shedding further light on asset price reactions to monetary policy: by looking at the whole distribution of market expectations, we can assess whether central bank communication increases “fundamental” uncertainty and thus whether public announcements are welfare improving or reducing. Moreover, by carrying out a comparative study exercise and comparing two different communication policies, ECB versus Fed, we can draw important normative conclusions on what is the most effective communication policy. Other improvements include the time-series analysis of a full interest rate cycle, the potential better methods to extract risk-neutral PDFs, and the precise assessment of the effects of the ECB’s words, separately from the effects of its deeds, by using tick-by-tick option price data to derive the whole distribution of market expectations. Second, we contribute to the empirical finance literature by analyzing the effects of a new type of news item, specifically the information originating from central bank announcements, rather than scheduled macroeconomic announcements. The effects that we document have relevant implications not only for a better understanding of the monetary policy transmission mechanism, but also for yield curve modeling and for the microstructure of bond markets. The methodologies developed and the results found will be important both for a monetary economics and a finance audience. More general
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High-throughput vibrational fingerprinting by nanoplasmonics for disease biology' (VIBRANT-BIO).

assistant: **Innovation**

Devastating diseases such as Alzheimer’s, Parkinson’s and various cancers are still without cures, continue to undermine the quality of life for millions of people and impose significant economic burdens. Misfolded toxic proteins constitute the microscopic basis of these diseases, but little is understood about their structure and biological function. This is due the fact that current technologies are severely limited for molecular-level identification of protein structures and high-throughput analysis of biomolecular interactions.VIBRANT-BIO aims to introduce breakthrough mid-infrared spectroscopy technologies, including the first spectroscopic microarray, to overcome the limitations of current methods by enabling complete profiling of biomolecules from identification of their structure and composition to their biological function. To achieve its ambitious goals, VIBRANT-BIO will exploit plasmonics and newly discovered two-dimensional nanomaterials such as graphene and explore the ultimate limits of light-matter interaction to demonstrate biosensors with extreme sensitivity, throughput and functionality, well beyond the state-of the art. It will innovatively integrate nanoplasmonics with advanced photonics and bioanalytical tools to dramatically enhance sensor performance and introduce new functionalities. The proposed technologies will be applied to study toxic amyloid-beta proteins and their interaction with lipid membranes for understanding the molecular mechanisms underlying Alzheimer’s disease.VIBRANT-BIO will contribute to define the road-map for next generation biosensor and spectroscopy technologies through interdisciplinary research covering physics, engineering, chemistry and biology. The capability of the proposed systems to analyze a broad range and ultra-l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring quantum observables at the LHC' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The main motivation driving the research in collider particle physics is the possibility to address some of the mysteries in the fundamental inner workings of our Universe and to answer to questions left open by the Standard Model of particle physics (SM).Despite the unprecedented energy reached and the large amount of data collected at the Large Hadron Collider (LHC) no convincing evidence of physics beyond the SM has been found. The start of the third LHC data-taking phase (2022) call for novel and unconventional approaches to search for new phenomena, looking in directions yet to be explored. This project proposes to exploit quantum effects, and in particular entanglement among particles as a new observable to probe interactions at high scales. By leveraging on quantum information concepts and techniques, I will explore new experimental strategies to analyse collider final states searching for SM extensions, through unexpected modifications of quantum correlations. The sensitivity of quantum correlations to new physics effects will be investigated both through a model independent effective approach as well as through specific models encompassing new resonances.This proposal aims to provide a first complete guidance and therefore to open the way to LHC experiments on how to perform and interpret measurements of quantum observables in the WW and top pair final states, at low as well at high energy, with specific techniques optimised for each kinematical region. Its ambition lies not only in the scope but also in development of new experimental technique based on charm tagging that has the potential to enlarge the data sample and therefore significantly extend the reach of the new physics searches.


**Keywords:** Quantum information observables, data analysis, phenomen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Epitaxial technologies for ultimate scaling' (ET4US) under Sixth Framework.

assistant: **Objectives**

Silicon CMOS is rapidly running out of steam and the entire semiconductor industry is puzzled about what comes next as the roadmap advances towards the terahertz region. It is clear that virtually every material (gate, gate oxide and channel) used in the current transistor must be replaced within the next 3 - 4 years, without interruption in the industry's pace.Two high mobility material classes are emerging as potential silicon replacement: germanium (Ge) and compound semiconductors (CS). The goal of this project is to find out which one presents the best future technology platform. This formidable question requires a major rethinking of all materials and processes. It will be addressed here from all relevant aspects: advanced large area wafers, novel gate stacks and transistor processing. With a strict focus on a simple and well- defined process-flow as well as an innovative, fast materials characterization track, the main strengths and showstoppers for each material system will be identified.The first objective is to demonstrate that high mobility large area compliant substrates of Ge-on-insulator (GOI) and CS- on-insulator (CSOI) can be obtained. GOI, and CSOI will be grown by developing a strained oxide template on Si" technology based on molecular beam epitaxy (MBE). The second objective is to demonstrate high quality gate stacks on Ge and CS. The challenge is to find suitable high-k compounds that can be used as gate dielectrics while maintaining high channel mobilities. The development of amorphous or epitaxial (for double gate) metal gates is also an essential project component. The third objective is to integrate the new channel and gate materials with a 200 mm semiconductor wafer processing line to demonstrate high mobility transistors for a few well chosen m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Disassembly of signalling protein complexes in T cell plasma membrane domains' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Signalling via cell surface receptors is a key element of cell regulation. The physiological response of the cell touch external stimuli is determined by multimolecular complexes at the plasma membrane that allow for the interaction of signalling enzymes with their respective substrates. Despite extensive knowledge of proteins that compose these complexes, very little is understood about the structure and dynamics of signalling assemblies. Here, the well-characterised system of T cell activation via the T cell receptor (TCR) is used to study complexes of signalling enzymes and adaptors that form around activated TCR in sub domains of the T lymphocyte plasma membrane. Complex formation is nucleated by the Tran membrane adaptor protein LAT and induces the activation of multiple signalling enzymes, which catalyse downstream reactions leading to the physiological responses of the activated T cell. Subsequently, the complexes disintegrate in order to attenuate the signalling. This study addresses the mechanisms of T cell signalling complex disassembly using biochemical analysis of native signalling assemblies purified by a novel immunoisolation procedure. In particular, it aims to elucidate the role of proteins involved ¡n the negative regulation of T cell signalling noncomplex disintegration. Somatic mutants of the well-characterized leukaemia T cell line Junket and the powerful method of RNA interference will be employed to analyse complex disassembly in cells deficient in negative regulatory proteins. An important candidate for a role in complex disassembly is the tyrosine phosphate SHP-1, which dephosphorylates critical tyrosine residues of other signalling proteins. Using a cell-free assay, it is planned to identify cryptozoic factors that are potentially involved in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sexual selection in plants: testing new ideas on the perception of the mating environment and on the mate choice physiology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Sexual selection has been extensively studied in the animal kingdom but much less so in plants. Nevertheless, increasing evidences suggest that sexual selection has played an important role in shaping plant reproductive strategies. Besides the strong paucity of study on plant sexual selection, the field has mostly focused on male-male competition occurring during the phase of pollen dispersal. We are especially ignorant of whether plants have evolved the ability to filter mating partners based on their pollen grain characteristics during the post-pollination phase of the life-cycle, resembling a female choice. It is equally unknown whether plants have evolved some ability to perceive their reproductive opportunities and plastically adjust their vegetative and reproductive morphologies as to maximize their chances to access mates. The PERCEPSION project uses a multi-disciplinary approach combining experimental evolution, paternity analyses and physiological analyses to study aspects of plant perception and filtering of mating partners. PERCEPSION aims at  (1) quantifying the variation between females in their style physiology during the post-pollination phase and relate it with the number of mates and with the performance of pollen grains of their partners; (2) evaluating through experimental evolution both the evolution of style morphology and physiology linked to their ability to filter pollen grains and the evolution of pollen grain performance in situations of monoandry vs. polyandry; (3) testing empirically whether plant-plant communication allows plants to perceive their mating opportunities and the genetic diversity of their mates and plastically adjust their reproductive strategy to maximize their chances to mate and (4) evaluating empirically whether mechanisms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Radiation Hard Resistive Random-Access Memory' (R2RAM).

assistant: **Concept**

The project aims to realize a strong methodology for the development and design of a radiation hard non-volatile memory technology by using standard CMOS silicon processing. Since standard silicon memories, such as flash memories tend to fail under irradiation, a new approach is envisaged: the development of a specific memory technology, so called resistive random-access memory (RRAM), which is able to sustain heavy ions and other charged particles. The switching effect of RRAM devices is caused by chemical Redox-reactions, therefore, radiation effects like total ionizing dose and single event effects don’t affect the switching mechanism.Semiconductor memories, among rad hard integrated circuit scenario, are one of the most critical topics for space applications. Actually both volatile and nonvolatile memories, excluding few exceptions, are integrated using standard processes and standard architectures. This means that the final device is typically at least Rad tolerant and not Rad Hard and failure during mission is avoided using Error Correcting Code techniques including redundancy at the board level. The basic goal of the project is to give a methodology for the development of a new rad-hard nonvolatile RRAM memory with high-performance features like good retention, re-programmability and cycling, and realize a prototype (1Mbit RRAM memory) in order to validate the approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CHARACTERIZATION OF THE ANTIVIRAL ACTIVITY OF BCA2', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

BCA2 (Breast Cancer-Associated gene 2, also known as RNF115, ZNF364 or Rabring7) is a cytoplasmic RING-finger E3 ubiquitin ligase that is upregulated in most breast cancer cell lines in response to estrogen. A recent study showed that BCA2 interacts with the cytoplasmic domain of tetherin/BST2 to promote the internalization and degradation of tethered HIV-1 particles, and that the E3 ligase activity of BCA2 is dispensable to enhance the tetherin-mediated restriction of HIV-1. Therefore, BCA2 would act as a tetherin co-factor, lacking antiviral activity in cells not expressing tetherin.However, here we show for the first time that BCA2 also inhibits virus production in a tetherin-independent manner by reducing the cellular levels of HIV-1 Gag, and that this activity requires the E3 ligase activity. Furthermore, we show that BCA2 physically interacts with Gag and promotes its ubiquitination and lysosomal degradation, suggesting that BCA2 may be an innate antiviral factor that impedes virus assembly and release. We want to formally address this hypothesis by characterizing the molecular mechanism(s) of the tetherin-dependent and tetherin-independent antiviral activity of BCA2 (Specific Aim 1) and by identifying the molecules and cellular pathways that participate in the regulation of BCA2’s activity (Specific Aim 2). A better understanding of the innate mechanisms that limit virus production will help in the elaboration of antiretroviral drugs to contain virus replication in affected individuals. Therefore, the objectives outlined here are directly relevant to identifying new targets for antiretroviral therapy to control HIV-1 infection.