RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Virtual reality aided design blending cross-disciplinary aspects of architecture in a multi-simulation environment' to be submitted under Horizon 2020.

assistant: **Abstract**

The recent past of the AEC industry is characterized by digital breakthroughs that have dramatically shaped the design process. The powerful programs that are currently available offer unlimited possibilities, allowing complex and creative designs to be modelled accurately with ease while enabling collaboration and Building Information Modeling. The realization of structurally complex constructions is an inter-disciplinary process that passes through the close collaboration of architects and engineers. By employing advanced VR applications, designers can immersively perceive and interact with the current status of their creations and realize the consequences of their decisions. Unfortunately, these solutions focus on the aesthetic aspect of architecture while ignoring the driving cause hidden behind each architectural creation, functionality, that can only be perceived through advanced simulations combined with powerful visualization. Therefore, architects and engineers that struggle to create complex constructions which abide to high functional standards cannot take full advantage of VR solutions. PrismArch aims to achieve a “prismatic blend” between aesthetics, simulation models and meta-information that can be presented in a contextualized and comprehensive manner in VR in order to allow collaborative manipulation of the design and accurate assessment of new design decisions. This achievement passes through intuitive interactions in a VR world with high-quality photorealistic graphics that satisfies the needs of all types of designers in parallel. By supporting dynamic collaboration among architects, structural and MEP engineers, PrismArch will allow them to jointly decide, preview and assess the outcome of their decisions towards a universal optimal solution. Throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Implementing value-based oncology care at European cancer hospitals: An AI-based framework for assessing real-life effectiveness of novel cancer therapies in real-time' in the context of a Horizon Europe call.

assistant: **Objectives**

ONCOVALUE will unlock the full potential of real world data (RWD) collected in European cancer hospitals and institutes to ease the decision-making of regulators on cost-effectiveness of novel cancer therapies. To achieve this, we build up data collection and processing capabilities of leading European cancer hospitals to create a high-quality clinical, quality of life, and adverse events data-sources. With the use powerful AI technologies, we will transform unstructured data originating from medical notes and medical images into structured data to enable analytics and real world evidence (RWE). This RWE will be directly available for clinicians for treatment management and for health regulatory and HTA bodies to adopt optimized data-driven methodologies for the effective assessment of medicinal products and digital health innovations. For that, we will provide an end-to-end infrastructure for RWD reporting in health regulatory and HTA decision-making and address the legal constraints in the cancer hospitals to ensure secure and legal access to RWD. Furthermore, ONCOVALUE will ensure the implementation of the developed guidelines and methodologies, by providing trainings for the collection and management of high-quality RWD in European cancer centres and for the analysis of this data by HTA and regulatory bodies. By opening the door to widespread regulatory and HTA integration of RWD, ONCOVALUE will lead to safer, more efficient, and affordable therapies, technologies, and digital solutions for (personalised) cancer care. As such, ONCOVALUE is positioned to contribute to increased cost-effectiveness and subsequent sustainability of cancer care. Systematic collection and evaluation of the patient reported outcomes will lead to improved well-being of the patients. Subsequ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Air-sea gas exchange - PArameterization of the Sea-Surface Microlayer Effect' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The Earth’s oceans absorb about 11 billion tonnes of carbon dioxide (CO2) each year, about 25% of all anthropogenic CO2. The oceans are huge reservoirs of CO2, and a better understanding on how the oceans absorb CO2 is critical for predicting climate change. The sea-surface microlayer (SML), the aqueous boundary layer between the ocean and atmosphere, plays an important role in the exchange of gases between the ocean and atmosphere. The effects of the SML on air-sea gas exchange have been widely ignored by past and current research efforts due to uncertainties to what extent the SML covers the oceans.  However, we recently reported the ubiquitous coverage of the oceans with SML, which pushes the SML into a new and wider context that is relevant to many ocean and climate sciences.I propose experiments at multiple scales, i.e. in laboratory tanks, wind wave tunnel, mesocosm and during a long-term field study. I propose a systematic field study measuring air-sea CO2 fluxes and mapping chemical, biological and physical properties of the SML. With the experiments on smaller scales, such measurements will allow for the first time (i) to define new parameters controlling gas fluxes, (ii) to quantify short-time and seasonal variability, (iii) to define global proxies for the effects of the SML, and (iv) to develop and apply a new parameterization for the correction of global CO2 flux data. For the first time, biogeochemical processes relevant to carbon cycling are investigated on the ocean’s surface at an interfacial level. Furthermore, I aim to reconstruct the natural composition of the SML in a wind-wave tunnel to study its ability to modify the ocean’s surface at well-defined wind regimes.The results from the proposed studies can form the basis for an improvement of current
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cytoskeleton architecture in host cells during Listeria infection using cryo-electron tomography' (3DCELLART), addressing dissemination and exploitation.

assistant: **Impact**

Bacterial infection into host cells is an important and highly active field of research. Understanding the interactions and the distribution of the host-cell scaffolding protein network during bacterial entry poses a major challenge. The molecular architecture of actin comet tails, filamentous structures assembled by internalized bacteria to move inside the host-cell cytoplasm and from cell-to-cell, remains unknown. Cryo-electron tomography (cryo-ET) is the most advanced method for visualizing the architecture of hydrated cells at a resolution better than 5 nm. Cryo-ET will be used to visualize the three dimensional (3D) cytoskeleton reorganization directly in eukaryotic cells infected by Listeria. Measurements will be performed at cryo-temperatures, on vitrified cell samples preserved in a close-to-life state. Specimen thickness limitations will be overcome by the use of the focused ion beam (FIB) micro-machining method, to obtain 500 nm thick samples as required for the collection of good data. Cryo-ET will be combined with correlative cryo-fluorescence microscopy, to localize the scaffolding components recruited during Listeria uptake and motility: host-cell actin, septin and clathrin. We expect to achieve nanometer resolution maps of the cell area of interest. The distribution and the ultrastructure of the cytoskeletal scaffold at Listeria entry and of Listeria actin comet tails will be provided. The work will provide unprecedented insight into cytoskeleton architecture during bacterial pathogenesis. The applicant obtained her PhD at a structural biology institute in France. Joining the Baumeister laboratory in Germany, and collaborating with the Cossart group, will allow her to address new challenging questions on the structural organisation of the cell, at unprece
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mitochondrial membrane-targeted compounds for cancer therapy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cancer is one of the leading causes of death in Europe. The economic impact of cancer in Europe has been quantified with a total cost of 126 billion €, including healthcare costs and productivity losses. Although many efforts have been devoted to eradicate cancer, the current treatments are associated with severe side effects and high toxicity. Alternatively, the next generation of cancer treatments targets only malignant cells, which exhibit unique biochemical hallmarks different from their normal counterparts. For example, cancer cell mitochondria are structurally and functionally different from healthy cells. As mitochondria are the waterline of cellular viability, they represent a more effective therapeutic target as compared to current protein targeted therapies. Here, we propose a novel approach whereby the control of cell proliferation and survival is achieved by means of regulation of the membrane properties of the cancer cell mitochondria by means of a lipophilic cationic drug, which efficiently accumulates in mitochondria. Our approach meets the requirements of developing, protecting and commercializing alternative therapies leading to an improvement of life quality and survival rate of cancer patients as well as an improvement in economic terms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interoperability and automated mapping' (INTAMAP).

assistant: **Innovation**

The main objective of this project is to develop an interoperable framework for real time automatic mapping of critical environmental variables by extending spatial statistical methods and employing open, web-based, data exchange and visualisation tools. To illustrate the potential of the framework at the European scale we will apply the framework to produce a system for automatic mapping of radiation levels reported by 29 European countries that participate in the European radiological data exchange platform (EURDEP).In case of hazards and emergencies (e.g. pollution peaks, nuclear/radiological accidents, flash-floods), maps of environmental variables interpolated from monitoring network measurements are needed in real time with minimum or no human intervention to reflect the monitored situation. In particular when dealing with unforeseen events (hot spots" or extreme values) environmental monitoring systems (EMS) usually lack adequate automatic mapping systems. Because spatial interpolation has an associated interpolation error, an automatic mapping system must inform decision makers about the uncertainties associated with the interpolated maps, such as by means of probabilities that a critical threshold is exceeded over a certain geographic region. Combining these probabilities with population density yields a system for rapid assessment of exposed population at risk.This project addresses key issues of GMES and integrates the results in an INSPIRE compliant framework, based on open standards (OGC/Orchestra/OASIS) and web (feature) services. Hence, the project has the ambition to lay down the foundations that set the technology and science necessary to realise the above objectives in the most accurate, reliable and extensible form."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes'.

assistant: **Innovation**

Medically related Life Sciences use the mouse as a model system to understand the molecular basis of health and disease in humans (>95% similarity of genes in humans and mice). An essential task for Biomedical Sciences in the 21st century will be the functional analysis of mouse models for every gene in the mammalian genome. The major bottlenecks identified by the user community will be proper characterization (Mouse Clinics), archiving and dissemination of mouse disease models to the research laboratories. The current capacities, governance structures and funding strategies of existing infrastructures will not be able to serve the upcoming urgent needs. Thus it is imperative to organise and establish now an efficient distributed infrastructure for the phenotyping, archiving and dissemination of mouse models on a well concerted, large-scale and pan-European level. This will be a prerequisite for maintaining Europe’s leading role in the functional annotation of the mouse genome. Infrafrontier will guarantee the accessibility of mouse models and will be essential to facilitate their exploitation. Infrafrontier integrates 15 European laboratories with exceptional track records to implement and run large-scale infrastructures. Infrafrontier builds on existing infrastructures under EMMA and EUMODIC and forms a coalition with a significant number of funding agencies to develop the prerequisites to a common European infrastructure. The Infrafrontier preparatory phase aims to organise a stable and sustainable infrastructure by 1) the identification of the most suitable legal form, 2) developing a business plan based on a sustainable funding concept, 3) reaching a legal agreement between all partners and 4) providing a strategic plan for the construction phase. Infrafrontier wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Trace Metals Monitoring in Surface Marine Waters and Estuaries (Cd,Zn,Pb,Hg,Cu,Fe,Mn and Co)' under Fourth Framework.

assistant: **Concept**

The project is aiming at the development of sensors for metals in marine environments with special emphasis on new technologies and improvement of existing technologies. The major drawback of present analytical tools is that they are often fragile and their application in stand-alone systems is difficult. Optical techniques based on molecular spectroscopy offer distinct advantages for reason of simplicity and absence of physical contact between the detection system and the analytes. In particular, luminescence methods (fluorescence, phosphorescence, chemiluminescence) offer potential advantages in ion determination: high sensitivity, ease of automation and straightforward application to fibre optics remote sensing. Specifically, the following metals will be addressed: Cd, Zn, Hg, Pb, Cu, Fe, Co and Mn but the technology that will be developed is applicable to other metals. Specific objectives are as follows:  a/ the participants in the project will develop optical sensing techniques for monitoring the metals by fluorescence (Cd, Zn), phosphorescence (Hg, Pb) or chemiluminescence (Cu, Fe, Mn, Co). b/ an instrumentation for steady and time-dependent emission based on an optical transient recorder will be constructed and adapted to the specific requirements of the three luminescence techniques. Timedependent intensities will provide a signature for the cations when needed. c/ analytical methodologies based on optical sensing will be developed and assessed for the eight metals. d/ speciation of the metals will be addressed, therefore analysis will be performed on untreated marine samples and U.V. digested samples. e/ automated operationel in-situ and on-line preconcentrators will be designed and constructed to meet the analytical requirements when appropriat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'PHYSICS AND TECHNOLOGY OF ELEMENTAL, ALLOY AND COMPOUND SEMICONDUCTOR NANOCRYSTALS: MATERIALS AND DEVICES' under Sixth Framework.

assistant: **Concept**

The primary objective of this project is to develop fundamental knowledge on the production techniques, characterization and methods of applications of semiconductor Nan crystals to light emitting devices and floating gate memories. Three main research directions can be identified in the project: First, physics and chemistry of a number of elemental, alloy and compound semiconductor Nan crystal formation and mechanisms of charge transport and light emission will be studied in a systematic way to acquire fundamental knowledge. Second, methods and technology of obtaining new materials with well-characterized Nan crystals suitable for use in device work will be developed. Finally, devices such as Metal Oxide Semiconductor (MOS) for use in flash memories and light-emitting devices (Leeds) will be designed, fabricated and tested as prototypes of devices incorporating the unique features of Nan crystals. Full cycle starting from material processing to the demonstration of devices will be covered. Different materials, production techniques, processing conditions and characterization techniques will be employed to reach comprehensive results for the science and technology of semiconductor Nan crystals. As its main objectives are strongly related to the size dependent phenomena in semiconductors and its outcomes will form the basis for the new production techniques in the modern microelectronic and photon industry, this project addresses topics with the following activity codes of NMP Work Program:3.4.1.1. ,3.4.3.1.The project has been broken into 3 main work packages: WP1 deals with the Is and Gee Nan crystals prepared in different media and processed by various techniques. WP2 is related to the production and characterization of some alloy and compound semiconductor Nan crysta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease or abnormal loading conditions. There are four major classifications of cardiomyopathy: hypertrophic (HCM), dilated (DCM), restrictive (RCM), and arrhythmogenic right ventricular (ARVC). Familial cardiomyopathies (FCM) are most commonly diagnosed, or progress of the disease is monitored, through in vivo imaging, with either echocardiography or, increasingly, cardiac magnetic resonance imaging (MRI). The treatment of symptoms of FCM by established therapies could only in part improve the outcome, but novel therapies need to be developed to affect the disease process and time course more fundamentally. SILICOFCM project will develop in silico computational cloud platform which will integrate from stopped-flow molecular kinetic assays to magnetic resonance imaging of the whole heart, bioinformatics and image processing tools with state of the art computer models with the aim to reduce animal and clinical studies for a new drug development and optimized clinical therapy of FCM.The developed system will be distributed on the cloud platforms in order to achieve efficient data storage and high-performance computing, that can offer end users results in reasonably short time. Academic technical partners IIT, UOI, UL and BSC will be responsible for developing and integration of in silico cloud computational platform with multi-scale cardiac muscle modelling which include experiments on protein mutation in vitro from UNIKENT, UNIFI and UW. Bioinformatics tools will be integrated by US company SBG. Clinical partners UNEW, ICVDV, UPMC and UHREG will do retro