RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low temperature-pressure processing of foods : safety and quality aspects, process parameters and consumer acceptance' in the context of a Fifth Framework call.

assistant: **Objectives**

The aim of this project is to address and overcome specific scientific and technological hurdles which is necessary to make an informed judgement of the relevance of food related effects of pressure in the low temperature domain (SAFE ICE) as to realize and deliver their full benefits to the end users. To comply with this goal the project is organized into three objectives:(1) to accumulate systematic data regarding thermo physical properties, safety, quality and stability aspects of pressure freezing and thawing of foods,(2) to develop models for SAFE ICE processes related to safety, quality and stability aspects as well as consumer acceptability of foods,(3) to use the knowledge generated for product evaluation and optimisation, for process control and process concept development and for educated judgements on consumer aspects aiding the identification of critical process parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pilots for Healthy and Active Ageing', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Pharaon’s overall objective is to make a reality smart and active living for Europe’s ageing population by creating a set of integrated and highly customizable interoperable open platforms with advanced services, devices, and tools including IoT, artificial intelligence, robotics, cloud computing, smart wearables, big data, and intelligent analytics. Platform interoperability will be implemented within Pharaon ecosystems and platforms, as well as other standardised platforms within health and other domains (energy, transport and smart cities). Pharaon will consider relevant standards and will contribute to them with the help of the two standardisation bodies of the consortium. Data privacy, cybersecurity, interoperability and openness will be key design principles to pursue through the requirements generated by Pharaon experts.Pharaon will be built upon mature existing state-of-the-art open platforms and technologies/tools provided by the partners, which will be customised and will implement cloud technologies, AI techniques and traditional algorithms for big data intelligent analytics. A user-centric approach will be followed. Pharaon will evolve based on the user feedback and the results from a MAFEIP framework that will be implemented for impact assessment. Both inputs will be used to find innovative solutions through two “open calls”: (1) single solutions, and (2) solutions to be demonstrated in small-scale pilots.Pharaon’s integrated platforms will be validated in two stages: pre-validation and large-scale pilots (LSPs), in six different pilot sites: Murcia and Andalusia (Spain), Portugal, The Netherlands, Slovenia and Italy. A team of partners in each pilot will ensure its right development.A set of development tools will be created and made publicly available to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'CLimate change, Extreme weather and Air quality anomalies Resilience through novel Earth Observation advanced data analytics'.

assistant: **Objectives**

CLEAR-EO leverages on newly available satellite data like Meteosat Third Generation (MTG) and EUMETSAT Polar System Second Generation (EPS SG), along with European Cloud infrastructures like the European Weather Cloud, to develop an analysis and geo-spatial notification system on top of a federated data space. These core components will support the development of innovative applications and services such as on-demand decision making workflows for 1) flash floods in urban areas, 2) short and long-term Climate Change impacts adaptation in agriculture, and 3) accurate air quality forecasts, with the final goal to contribute and enhance the Copernicus and the EO/weather services ecosystem.CLEAR-EO teams up a multidisciplinary partnership from Research Organizations, weather forecasting centres, EO data and tech/cloud platform specialists to Group of Earth Observation (GEO)/Destination Earth (DestinE) contributors and SMEs to develop, demonstrate, and promote to relevant stakeholders and end-users new application developments and early exploitation of the new weather satellite data to support SDGs and European Green Deals.


**Keywords:** Meteosat  Third Generation, in-situ data, geospatial notifications, extreme weather events, flood, drought, EUMETSAT Polar Second Generation, Copernicus, European Weather Cloud, data space,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metropolitan cities and sustainable use of water.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Water management will be one of the main environmental problems of the 21st century. Large urban centres are major consumers of water but also offer unique opportunities for economies of scale in water conservation. Tackling water management at the city level makes also sense in terms of the clearly defined institutional framework, the direct motivation of local actors and the concentration of data and monitoring capacity. The objective of the proposed project is to identify and evaluate alternative sustainable policies and policy instruments for water management in metropolitan European cities and areas. This will involve building up a system of relevant indicators and performing a case study analysis of selected European cities? where the success and failure factors of existing policies will be thematically analyzed and the alternative strategies for the sustainable use of water will be assessed. The 1st work package of the project involves the preparation of expert reports by the partners of the research network in key topics relating to the sustainable use of water in metropolitan cities (e.g innovative technologies for urban water-saving", "socio-cultural factors shaping water demand", "experience from the use of financial instruments in water-saving", etc). In the 2nd work package. a list of appropriate indicators to measure the sustainability of urban water use will be prepared and measured in the case cities (Amsterdam, Athens, London, Seville, Tel Aviv). In the third work package policies affecting water use in the case cities will be evaluated in five key sectors (technology, administration, society, economy and environment) and the crucial barriers and critical success factors will be identified by survey research and will be illustrated by the pentagon prism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainable use of soil related to different agricultural practics - thematic strategy on soil' to be submitted under Sixth Framework.

assistant: **Abstract**

The general objective of the SSA is to provide detailed information on current risk assessment methodologies of soil threats used within the Member States. The selected soil threats are erosion, salinisation, organic matter decline, compaction and landslides. In this SSA all current risk assessments methodologies used in the EU are collected and evaluated by thematic experts. Subsequently, risk assessment methodologies are assessed in view of concepts, approaches, input parameters, deliverables, and level of integration of different soil threats. Scientific guidelines are provided on possibilities for EU wide parameter harmonization. For parameters that can not or should not be harmonized scientific guidelines are provided on the choice of a certain approach. This SSA addresses the methodologies used to identify geographical areas at risk for (combinations of) different soil threats...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Single-cell and live-imaging approaches to study Intra-tumor Heterogeneity and Population Dynamics in Colorectal cancer organoids' in the context of a Horizon Europe call.

assistant: **Objectives**

Colorectal cancer (CRC) is one of the most diagnosed cancer worldwide. Though several treatment strategies are available today, around a million people die of this disease each year worldwide. Thus, there is still a pivotal need for new and more effective treatments. Intra-tumor cellular heterogeneity has emerged lately as an intrinsic feature of malignancies and as one of the factors responsible for therapy resistance or tolerance. However, the role that phenotypically distinct subpopulations have on tumor biology is far from being understood. This multi-disciplinary proposal is based on the use of cutting-edge techniques to unravel the basic features of intra-tumor phenotypic heterogeneity and subpopulations interactions. The goals are to (1) identify and characterize phenotypically distinct subpopulations on a set of metastatic CRC human-derived organoids by single-cell RNA sequencing; (2) monitor their plasticity (transitions) by generation of fluorescent reporter lines and live-imaging lineage tracing; (3) study the impact of each subpopulation on tumor growth, and identify underlying molecular pathways by live-imaging. Ambitiously, this project aims at witnessing phenotypic transitions in living cells, a challenging task that has not been fully accomplished yet, with relevant therapeutic consequences. It is expected that this project will provide the scientific community with a deeper understanding on subpopulations dynamics in colorectal cancer, that could ultimately result in the discovery of novel treatment strategies, such as targeting a specific subpopulation or interfering with molecular determinants of transitions. Moreover, it will foster the independent career of the applicant as a researcher by expanding her skills and international network. This project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Towards a European Competence Centre for Nuclear Magnetic Resonance (NMR) on Actinides', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of this proposal is to initiate building up NMR competence to support establishment of a “European Competence Centre for NMR on Actinides”. Building competence and identification of future trends and promising application fields in NMR actinide research will serve as the basis for specifying required NMR instrumentation and infrastructure in the “European Competence Centre for NMR on Actinides” to meet these experimental needs. The establishment of a the Centre for NMR on Actinides itself is a joint effort of the Forschungszentrum Karlsruhe Institut für Nukleare Entsorgung and the European Joint Research Centre Institute for Transuranium Elements, both located on the same site. It will provide access to NMR techniques, which are otherwise not available in Europe for working with radionuclides; there are no solid sate NMR instruments at all in Europe and only a few for investigations of liquid samples (e.g., in Marcoule, France; ATALANTE). Building up NMR actinide competence will be met via two basic activities: 1) formation of a NMR expert roundtable and 2) organization of a European Workshop for NMR on Nuclear Materials. Only through dialogue with the actinide research community in the planned workshop and with recognized experts in the round table can we establish the “European Competence Centre for NMR on Actinides”, which can successfully plan facilities needed for later access by European nuclear institutes and universities. This support action will also make the new NMR nuclear facilities to be available at the “European Competence Centre for NMR on Actinides” known to a broad base of potential European users. These NMR facilities available to the European actinide community will strengthen basic scientific understanding in a wide field of applications, e.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Safe and effective immunotherapy of leukaemia with suicide gene-modified human T lymphocytes retaining anti-minor histocompatibility antigen reactivity' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Allogeneic haematopoietic stem cell transplantation (allo-SCT) is the curative option for leukaemia and other haematological tumours. In allo-SCT donor T lymphocytes play a crucial therapeutic role both in providing immunological reconstitution and eradica ting malignant cells. Despite this, the use of donor T cells is limited by the occurrence of fatal graft-versus-host disease (GvHD). A suicide gene codes for a protein able to convert a non-toxic pro-drug into a toxic product. Donor T lymphocytes expressin g the herpes simplex virus-thymidine kinase suicide gene (TK) become sensitive to ganciclovir (GCV) and can be eliminated in the case of GvHD. The aim of this project is to generate TK+ human T lymphocytes that possess substantial anti-leukaemia activity i n vivo. To this I will focus on the response against the HA-1 minor histocompatibility antigen. HA-1 is one of the major targets of immune elimination of leukaemia following allo-SCT, also known as the graft-versus-leukaemia effect (GvL). I will verify in vitro what protocol results in TK+ human T lymphocytes with anti-HA-1 reactivity and test them in vivo for GvL and for GvHD. To this I will treat NOD/scid mice harbouring HA-1+ human leukemias and/or grafted with HA-1+ full-thickness human skin grafts with HA-1-specific TK+ lymphocytes. I will also demonstrate the safety of the treatment, as the possibility to eliminate TK+ cells by GCV administration in vivo. The results of this project will be of paramount importance in the validation of suicide gene ther apy (SGT) as a tool to exploit safe and effective allo-SCT for the cure of haematological and possibly solid tumours.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mobile high-resolution 3D-Scanner and 3D data analysis for forensic evidence fast track to innovation' under Horizon 2020.

assistant: **Concept**

Crime is a major factor in reducing the level of civil security. The percentage of solved crime is less than 70% in more than half of the EU countries in some it is less than 50%. A very important part of crime investigation is the capturing and analysis of forensic evidence. In High Volume Crimes, such as burglary, a common trace type are footwear and tyre track traces. At present the recording and analysis of such traces can only be mitigated (if at all) through time consuming procedures. In the last years the FP7 project 3D-Forensics (www.3D-Forensics.eu) developed and evaluated a promising approach to fill gaps in the performance of actual tools. Footwear and tyre traces are captured using modern optical 3D-scanning technology and investigated using a 3D analysis software focussed on forensic end users. The project culminated in the demonstration of the system prototype outdoors under the same conditions of those typically found at crime scenes by the Dutch police from the region of Zeeland West-Brabant.3D-Forensics / FTI will bridge the so called “valley of death” between a successful research and technological development and market introduction of innovation. It will finish off the footwear and tyre trace 3D scanning and analysis idea from an already advanced project output to make it market mature and ready for launch. In essence 3D-Forensics / FTI will implement the last steps identified as necessary at the end of the previous FP7 project. The resulting advanced prototypes will be tested, including in “round robin”  tests by six forensic end users for performance verification and in a further phase the prototypes from a pilot line with the same or very similar specifications as the first product to be launched will be validated in a relevant accredited process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ultracold negative ions by laser cooling' (UNIC) under Seventh Framework.

assistant: **Objectives**

Laser cooling is a well-established technique for the creation of ultracold particle ensembles in beams or traps. Over the past 30 years, it has become an indispensable tool in atomic physics and has opened many exciting new research fields. Both in positive atomic ions and in neutral atoms, the valence electron is bound in a Coulomb potential. The resulting infinite series of excited states provides a wide choice of suitable cooling transitions in many ionic and atomic systems. Surprisingly, laser cooling of negative atomic ions has never been achieved. The binding of the valence electron in these systems is based on electron electron correlation effects, which drop off quickly as the excess electron is removed from the neutral core. Consequently, anions are easily neutralized and only a few of them have excited levels. When excited states do occur, they are usually sub-levels of the ground state, meaning that transitions between the ground and excited state are weak and laser cooling would take prohibitively long. However, only a few years ago, a strong transition between the ground state and an opposite-parity excited state was found in the negative osmium ion. With this discovery, the laser cooling of atomic anions has finally come into reach. High-resolution optical spectroscopy on negative osmium has been carried out by the applicant, confirming the existence of a potential laser cooling transition. The aim of the proposed project is the first-ever demonstration of atomic-anion laser cooling. Ultimately, laser-cooled atomic anions could be used to cool any other negative-ion species by confining them simultaneously in a trap. The proposed technique is therefore applicable to a wide range of research fields in which ultracold negative ions are required.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modelling and Optimization of Microfluidic Devices for Biomedical Applications' to be submitted under Seventh Framework.

assistant: **Abstract**

Circulating tumor cells (CTCs) are isolated tumor cells disseminated from the site of disease in metastatic or primary cancers, including breast, prostate, and lung cancer. CTCs can be identified and counted in the peripheral blood of patients. The biological analysis of CTCs using lab-on-chip technologies effectively diagnose the disease, determine personalized therapies, and adjust treatments in real time. This significantly increases the survival chance of the patients. Because of their rare occurrence, a few CTCs per 1 mL of blood, the CTCs must be isolated from the blood sample. Recent developments of microfluidic devices made a significant breakthrough in the detection and filtration of CTCs from blood.The aim of the project is to incorporate rigorous optimization techniques in the development of such devices. In the design process of currently manufactured devices, the focus has not been put on the performance optimization. The use of mathematically justified optimization techniques offers huge potential for increasing the efficiency.A computer tool for simulation of complex processes inside microfluidic devices will be developed. A novel capture mechanism based on local affinity interactions will be elaborated. An optimization framework will be established and implemented in the software. With this framework, new devices with higher efficiency will be designed.During the designing process, different concepts will be optimized, e.g. geometry, blood flow velocities, external magnetic fields manipulating ferromagnetic parts of the device, and other. The optimization will be carried out in a rigorous way by applying iterative optimization techniques, which is a novel element in the development of microfluidic devices.The underlying physical models will be properly c