RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamics of RAR1-SGT1 complexes in disease resistance' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Genetic approaches has led to the identification of several components of the gene-for-gene resistance pathway. RAR1 and SGT1 are required for the function of many disese resistance R proteins. RAR1 and SGT1 interact with each other and with HSP90, a cytosolic chaperon also required for the function of some R proteins. SGT1 presents co-chaperone features and interaction between HSP90 and R-proteins has also been reported. Collectively, these data suggest that RAR1 and SGT1 proteins might be components of R-protein heterocomplexes or be required for their formation or activation upon pathogen infection. Although RAR1, SGT1 and HSP90 interacts with each others, it remains to be shown whether RAR1 and/or SGT1 associate together with HSP90 and R proteins in a single complex. Additionally, SGT1 has been demonstrated to be associated with the SCF E3 ubiquitin ligase and COP9 signalosome complexes, suggesting that RAR1-SGT1 complexes may also play a role in the ubiquitin/proteasome system. In this project I assess the role of RAR1-SGT1 complexes in R-protein signalling. The project will adopt a biochemical approach to reconstitute R proteins and the RAR1-SGT1-HSP90 complexes in vitro and to identify further components of the RAR1-SGT1 hetero-complexes from plant extr acts using affinity chromatography methods followed by mass spectrometry. I also aim to identify new RAR1 and SGT1 interacting proteins using a split-ubiquitin yeast two hybrid screening. In addition, I plan to visualise these interactions in vivo using Bi FC analysis to study their dynamics during the defence response.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Re engineering and regenerating the knee' (REGENKNEE) under Seventh Framework.

assistant: **Objectives**

Over fifteen percent of the western population suffer from osteoarthritis. For severe disability, total joint replacement remains the onlty treatment. The ageing population is growing and their expectations for an active, high quality lifestyle is increasing. The number of knee joint replacements is predicted to increase five time by 2025. While technology for knee joint replacements has advanced considerably over the last decade,  knee joint replacements do yet restore the natural function or provide the longevity expected for a population expecting - fifty more active years after fifty. An alternative is needed.We wil address the potential of regenerative biological scaffolds to re-engineer and regenerate the knee in early stage degenerative disease. We will build upon our successful research and clinical trials in the application of regenerative biological scaffolds in the cardiovascular system.. We will research and develop bioprocesses to produce a portfolio of tissue specific regenerative biological scaffolds to replace disrupted and degenerative tissues in the knee, including ligaments, meniscus, bone and cartilage. and evaluate their biomechanical, biotribological and biological function. We will investigate the regenerative potential of these novel biological scaffolds individually and collectively in the knee as a bioengineering system.This research will open the opportunity for a paradigm shift for treatment of degenerative disease in the knee and offer the potential for substantially delaying the need for a joint replacement in hundreds of thousands of patients every year.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hydrowashr 2000' (HW2000).

assistant: **Concept**

Hydrowashr has developed an all-in-one washing device which will save up to 99% of water each time someone uses it for washing their hands. Next to that it is a disruptive innovation in the sanitary market, in the light of environmental, economical, hygienically and aesthetic values.This proposal describes Hydrowashr’s innovation and why a feasibility study will be necessary to further develop, validate and commercialize the innovation: the HW2000. Hydrowashr has developed HW2000 (Hydrowashr 2000): a product, based on an innovative spraying system, which allows individuals to wash their hands in a more sustainable and hygienic way. How it works: the user puts his hands into the HW2000. The, completely touch free, washing process works with microscopic droplets of water that are fired on the skin trough a rapid flow of air. Then the hands are dried in the same air flow. After 20 seconds, the hands are clean, dry, warm and soft. Because of this new spraying technology, up to 99% water will be saved each time. At the same time the system cleans hands better than existing solutions, providing better hygiene.Hydrowashr B.V. has been founded in 2012 and is specialized in water technology. Hydrowashr is located in Leeuwarden, the ‘Capital of water technology’. In Leeuwarden the Water Campus allows companies to develop and test innovative water technologies.Fresh water is globally becoming a scarce resource. In a research of 2007, initiated by the European Commission, water scarcity and drought is identified as a growing European problem. According to the report, water savings will help addressing these problems. Additionally water savings will provide financial, economic, environmental and other additional benefits. The importance of innovative water solutions is also stressed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Buddhism, Diplomacy, and Travel: Identity- and Nation-Building in Bhutan' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This research project is an investigation of identity- and nation-building in eighteenth-century Bhutan with a particular focus on the agency of Buddhist masters as important diplomats and Bhutan's entangled history with Tibet. This will enable a novel understanding of Bhutan's religious and political history, particularly its Buddhism-induced development model of Gross National Happiness (GNH) that has not yet received systematic historical analysis in religious studies in Europe despite its global popularity as an example of alternative sustainable economic models. Furthermore, for the first time, Bhutan's historical role in linking South Asia, the British Raj, and East Asia will be systematically addressed. The research output will significantly advance both fields - that of Tibetology and religious studies. The innovative research design combines historical-philological methods by analyzing a thus far untranslated corpus of Bhutanese/Tibetan primary sources with a theoretical framework from religious studies focusing on identity and social differentiation. Therefore, the project is in its methodology, output, and impact inter-disciplinary. The researcher will produce a draft for a single monograph publication for habilitation in Germany. The proposed project involves as the researcher a German Tibetologist trained in Germany, Canada, India, and Bhutan reintegrating to Germany to work with a religious/Buddhist studies scholar at Leipzig University. This will enable substantial training for the researcher in religious studies and impactful two-way knowledge exchange between the researcher and the host institution due to the international experience of the researcher. An intersectional secondment at The British Library Endangered Archives Programme (London) will provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Distributed Biological Algorithms' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project proposes a new application for computational reasoning. More specifically, the purpose of this interdisciplinary project is to demonstrate the usefulness of an algorithmic perspective in studies of complex biological systems. We focus on the domain of collective behavior, and demonstrate the benefits of using techniques from the field of theoretical distributed computing in order to establish algorithmic insights regarding the behavior of biological ensembles. The project includes three related tasks, for which we have already obtained promising preliminary results. Each task contains a purely theoretical algorithmic component as well as one which integrates theoretical algorithmic studies with experiments. Most experiments are strategically designed by the PI based on computational insights, and are physically conducted by experimental biologists that have been carefully chosen by the PI. In turn, experimental outcomes will be theoretically analyzed via an algorithmic perspective. By this integration, we aim at deciphering how a biological individual (such as an ant) “thinks”, without having direct access to the neurological process within its brain, and how such limited individuals assemble into ensembles that appear to be far greater than the sum of their parts. The ultimate vision behind this project is to enable the formation of a new scientific field, called algorithmic biology, that bases biological studies on theoretical algorithmic insights.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Endothermic technology for energy efficient housing in the Eu' to be submitted under Fifth Framework.

assistant: **Abstract**

The aims of the project are:1) To determine the energy requirements for space heating, hot water and cooling over the year in different regions of the EU2) To formulate a linkage between the energy requirements in different regions of Europe and the design parameters for selecting and sizing the components of the endothermic system3 ) To design and set up five test endohouses in different climatic regions of the EU4) To perform detailed monitoring of the test endohouses and climatic variables over long periods covering the heating and cooling seasons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart Maintenance and the Rail Traveller Experience' under Horizon 2020.

assistant: **Concept**

Most maintenance activities in the current railway system are carried out on a scheduled basis. This potentially means that components and sub systems are not replaced at the optimum time and that components fail between interventions. SMaRTE will provide the methodology for implementation of a Condition Based Maintenance system appropriate for the railway. This will allow maintenance to be tailored around the actual remaining life of key components and will reduce costs and improve reliability and availability. Knowledge and experience from other sectors will be extracted and new scientific methods for handling data and setting up architectures and intelligent systems to process data will be developed; appropriate to the railway system. Case studies will be designed and carried out for two different but typical passenger railways and lessons learned will be used to improve the system definitions. The final result of the SMaRTE project will be a CBM system which works for passenger railways and will result in reduced system costs and improved system reliability. The premise of SMaRTE (Human Factors) is that reducing customer cognitive effort is key to rail usability. Achieving a more streamlined process of accessing rail should increase its attractiveness. Whilst there is substantial evidence on the impact of factors such as fares / journey time on rail usage, the impact of more subtle factors deterring passengers from using rail are less understood. SMaRTE places the focus on the customer, utilising an innovative multi-disciplinary approach to understand the primary factors impacting on user decisions to choose rail (or an alternative) – and producing new quantitative evidence on the relative importance of those factors. The final result of SMaRTE will be a set of quan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enhancing hypnotic suggestibility using noninvasive brain stimulation: Cognitive and neural mechanisms' to be submitted under Seventh Framework.

assistant: **Abstract**

Hypnosis is gaining increasing attention as a reliable and effective method for studying a wide variety of psychological and neurological phenomena. It is also a widely-recognized, efficacious form of treatment for pain. A limitation of both the experimental and clinical use of hypnosis is that it is most effective with highly suggestible individuals, who make up approximately only 10-15% of the population. The efficacy of hypnosis coupled with the recognition that it is most effective with a small subset of the population presents a clear motivation for increasing hypnotic suggestibility.The proposed project outlines four experiments that attempt to: 1) examine whether hypnotic suggestibility, as measured by cognitive control tasks, can be enhanced using transcranial direct current stimulation of frontal and parietal cortical regions; 2) investigate the regional haemodynamic and neurochemical changes underlying increases in hypnotic suggestibility; and 3) extend this approach to enhancing hypnotic analgesia during exposure to a nociceptive (painful) stimulus.The proposed project aims to combine non-invasive brain stimulation and functional neuroimaging techniques in novel ways to enhance hypnotic suggestibility and measure the neural basis of this increase. The project will also make a number of unique and important analytic advances by utilizing a variety of statistical techniques including response time distribution modelling, response time series analysis, and mediation analysis, which will provide a more refined understanding of the cognitive and neural mechanisms involved in the enhancement of hypnotic suggestibility.The expected results will have important implications for the experimental utilization of hypnosis in experimental psychology and cognitive neuroscie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dahlem Research Fellowship for Incoming Experienced Researchers' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Freie Universität Berlin is one of the largest universities in Germany and one with a most vibrant and diverse research spectrum. In the German Excellence Initiative of 2007, Freie Universität Berlin was awarded for its institutional strategy of the International Network University and eight further Excellence Projects most of them unique on the European or global level.An inherent component of this institutional strategy is the promotion of young researchers on all stages of the academic career.Freie Universität Berlin will therefore implement the Dahlem Research Fellowship scheme targeted at experienced researchers from all over the World. The new fellowship scheme will allow researchers to carry out cutting edge research projects in the outstanding environment of one of the university’s eight Excellence projects. The programme will integrate a network of leading researchers in the respective field for cooperation projects.In addition, fellows will benefit from the training support, mentoring and career development schemes jointly offered by the Excellence Projects and Dahlem Research School, the Center for the Promotion of Young Scientists at Freie Universität, which will also coordinate the programme.A highly elaborated selection ensures that only the best and brightest candidates will be admitted and that gender and trans-sectional aspects will be attentively considered.The uniqueness of the research fields, the extraordinary conditions for research and the support by training and mentoring in the Excellence Projects at Freie Universität Berlin will enable top level young researchers to raise quality of their research considerably and therefore to boost their own professional career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European driver's desk' in the context of a Fifth Framework call.

assistant: **Objectives**

In conformity with the EU policy the project aims at the improvement of interoperability in cross-border railway traffic by development, construction and evaluation of a new driver's desk that will be the core of modular train for application throughout Europe. Optimisation of human-vehicle interaction regarding working conditions, traffic safety and implementation of extended future-oriented monitoring/control capabilities are envisaged. Main project objectives are measurable improvements relating to man-machine-interface (e.g. reduction in reaction time), the supply industry (e.g. reductions in manufacturing costs, reduced time-to-market) and the Railways (e.g. reduced Life-Cycle costs). A multidisciplinary specification process will ensure the application of latest scientific knowledges. The evaluated specifications of desk concept (realised and evaluated as hardware mock-up) will serve as input document for future EU standard.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Efficient storage, access and transmission of whole-slide pathology images' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Traditionally, pathology slides are handled by cutting a tissue sample into paper-thin sections, and staining them, so to bring out regions of interest (RoIs). Pathologists then put these thin sections on a glass slide to be analyzed under a microscope. Recent advances on whole-slide digital scanners have made possible the digitization of pathology slides, thus allowing storing them as digital images. Consequently, traditional analysis techniques that rely on pathologists looking under a microscope are rapidly being complemented by techniques that rely on pathologists looking at digital images on a monitor.The digitization of pathology slides not only allows storing the imaging data for future research and clinical purposes, but also sharing them electronically for collaborative work. However, due to the high resolution required to digitize whole pathology slides, the resulting imaging data are usually very large in file size, which poses heavy demands on storage and transmission resources. Therefore, designing coding algorithms for efficient storage, access and transmission of whole-slide pathology images remains a challenge.The main objective of this proposal is to design a coding algorithm capable of reducing both storage and transmission bandwidth requirements needed for archival and communication of whole-slide pathology images of tissue biopsies. The proposed algorithm will reduce the amount of data needed to represent these images, with no loss of information, while providing scalability and RoI coding capabilities. The algorithm will be based on integer wavelet transformation for data decorrelation, automatic image segmentation for RoI coding and layered entropy coding for scalability.The successful completion of the proposed algorithm will facilitate the storag