RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Seeking solutions for the artificial pancreas: new methods for improving continuous glucose monitoring and closed-loop postprandial glycaemic control' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Near-normoglycaemia has been established as the control objective for most patients with diabetes. Automated glucose control, the so-called artificial pancreas, would represent the ideal solution for attainment of therapeutic goals in diabetic patients. However, several challenges do exist to effectively realize closed-loop control of blood glucose. In this proposal, two key issues for the success of the artificial pancreas will be addressed: accuracy of continuous glucose monitors (CGM) and management of meals. CGM estimate plasma glucose from measurements taken in the interstitium. However, variations of the plasma/interstitium glucose exchange may occur during dynamic conditions, explaining the poor performance of CGM in the hypoglycaemic range. The glucose clamp technique will be used in diabetic subjects to obtain controlled variations of glycaemia at different levels of insulinemia. Models of blood-interstitium glucose transport will be built and incorporated in advanced calibrations strategies aiming at improving monitors accuracy, as required for closed-loop glycaemic control. Besides, meals are one of the major perturbations to counteract and the main challenge found in current clinical validations of the few existing prototypes of an artificial pancreas. Clinical studies have demonstrated the ability of small manual pre-meal ‘priming’ boluses to reduce postprandial excursions during closed-loop control. Set inversion algorithms have proved in silico its efficiency to compute insulin administration to achieve a tight postprandial control with no hypoglycemia especially for big meals. A rigorous clinical testing of the set-inversion-based meal-control will be carried out and incorporated into closed-loop control strategies. Significant advances in postprandial c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Anti-CD3 systemic therapy in combination with antigen-specific intervention: A novel approach for treating type 1 diabetes' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Type 1 diabetes (T1D) is thought to be T-cell mediated auto-immune disease, where auto-aggressive CD4+ and CD8+ lymphocytes target and destroy the insulin producing pancreatic b-cells. During the last decade several studies focused on different immune-based therapies to treat or prevent T1D.Numerous data point towards two promising immune interventions:(1) The antigen specific prevention of T1D for example with DNA vaccines, proinsulin, GAD and insulin B chain, which can prevent T1D in more than 50% RIP-L CMV transgenic or NOD mice. Unfortunately, the protective effect of such strategies was only observed when the antigen was given early during the prediabetic phase.(2) In contrast, non-mitogenic anti-CD3 antibody is able to revert recent-onset TID in NOD m ice, which was initially discovered by Lucienne Chatenoud. This antibody has already been tested by Jeff Bluestone and Kevan Herold clinically and preserved C-peptide levels over the first year in recent-onset diabetics.The aim of our present study is based on the idea that combination of anti-CD3 systemic therapy with antigen specific approaches might result in a synergistic effect. We believe that anti-CD3 will act to reset" the immune system, then leaving a window for therapeutic intervention with anti gen specific treatments to induce regulation that can maintain long-term tolerance in T1D.This approach will be tested pre-clinically by using the NOD and RIP-LCMV transgenic mouse models treated with a commercial anti-CD3 Fab'2 in combination with islet specific-antigens (administered as DNA, peptides or full protein) after recent onset of T1D. In our opinion, this strategy will increase efficacy of antigen specific immunizations by opening a window for re-direction of the existing autoreactive response and/or de n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bringing CItizens, Models and Data together in Participatory, Interactive SociaL EXploratories' (CIMPLEX) targeting Horizon 2020.

assistant: **Abstract**

We propose visionary research to develop modeling, computational, and ICT tools needed to predict and influence disease spread and other contagion phenomena in complex social systems. To achieve non-incremental advances we will combine large scale, realistic, data-driven models with participatory data-collection and advanced methods for Big Data analysis. In particular we will go beyond the one-dimensional focus of current approaches tackling one aspect of the problem at a time. We will interconnect contagion progression (e.g. epidemics) with social adaptation, the economic impact and other systemic aspects that will finally allow a complete analysis of the inherent systemic risk. We will develop models dealing with multiple time and length scales simultaneously, leading to the definition of new, layered computational approaches. Towards policy impact and social response we will work to close the loop between models, data, behavior and perception and develop new concepts for the explanation, visualization and interaction with data and models both on individual and on collective level. We will cast the fundamental advances into an integrated system building on widely accepted open ICT technologies that will be used and useful beyond the project. As a tangible ICT outcome directed at facilitating the uptake and impact of the project, we will implement “Interactive Social Exploratories” defined as interactive environments which act as a front-end to a set of parameterizable and adjustable models, data analysis techniques, visualization methods and data collection frameworks. In summary, we aim to (1) produce fundamental theoretical, methodological and technological advances (2) mold them into a broadly usable ICT platform that will be a catalyst for producing, delivering,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular logic lab-on-a-vesicle for intracellular diagnostics' in the context of a Horizon 2020 call.

assistant: **Objectives**

A dysfunction of cells lining the inner walls of blood vessels, i.e. the endothelium, is the primary cause of many lifestyle related diseases. According to the WHO, those diseases accounted for 60% of all deaths worldwide in 2005. Tailor-made diagnostic tools for early and reliable identification of endothelial dysfunction are urgently needed both in fundamental research and clinical routine, respectively. The Marie Skłodowska-Curie action LOGIC LAB objects to develop and characterize innovative molecular logic gates that can be applied as advanced diagnostic tools for parallel analyte sensing in live mammalian cells. Thereby, providing a unique method to discover endothelial dysfunction and the onset of diseases much easier and earlier than so far. LOGIC LAB creates a multi-faceted and multi-sectoral research environment for the next generation of scientists in order to establish a novel type of molecular logic sensors that reliably operate in biological media – a crucial requirement for their application i.e. as rapid and easy-to-handle tools for intracellular diagnostics. With excellent cross-disciplinary scientific and complementary training provided in the network, we aim to educate highly-skilled young scientists in the fields of chemistry, physics and biology, who will significantly strengthen the international research community in the domain of molecular logic sensing. Thus, in the long term, LOGIC LAB aims to finally bridge the gap between lab bench and biological or medical practice. It is this gap, that so far prevents a wide-ranging use of existing molecular logic gates e.g. for the diagnosis of lifestyle-associated diseases.


**Keywords:** molecular logic gates, biological sensing, molecular spectroscopy, microfluidics, metabolomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Expansion bolt' (1994-1998) under Fourth Framework.

assistant: **Objectives**

This proposal is prepared with the aid of an Exploratory Award, which included a Research Feasibility Study. The research proposal concerns an exciting development in anchor bolts, which challenges the vast array of traditional designs used in the market, through exploiting polymer technology. Anchor bolts are currently sold to Industry, in particular the Construction Industry. Anchor bolts are presently divided into three categories of fixing products: light, medium and heavy duty applications i.e. typical variation in applications can be from using anchor bolts for securing a simple wall bracket to securing a tightly toleranced structural fixing in a bridge. The anchor bolts are also made in a range of sizes namely M6 M24 with various specifications used to cover the demands of different loads and applications with regard to the base material they are being fixed into e.g. concrete, bricks, blocks etc. Material specification for these bolts varies, using predominantly 4 different grades of steel namely 5.8 and 8.8 steel zinc plated. Also 304 and 316 stainless steel. In addition to this another system is used which is known as chemical anchors, which is a combination of resin and metal. Generally 3 variations in length for each of the above specifications is also provided to suit the various thickness of parts which may be fixed. Unfortunately for all the people involved in the fixings market from specifiers and stockists through to end users the selection process can best be described as a bit of a headache i.e. What design do we choose? What grade of steel? Will it work in the application we have? However the SME proposers believe that further research into using a polymer based anchor bolt design, coupled with a rigorous test programme to validate the hypothesis, wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Eukaryotic genomic origins, parasites, and the essential nature of mitochondria' (EUKORIGINMIT) under Seventh Framework.

assistant: **Objectives**

Understanding the origin and evolution of eukaryotes, their genomes and organelles, are among the most important and exciting challenges facing biology.  However, determining ancient gene origins tests methods and data to their limits, and it is unrealistic to expect progress to be easy.  A comparative cross-disciplinary approach involving sophisticated phylogenetics allied with mathematical understanding, offers the best hope of obtaining robust hypotheses for gene and genomic origins. It is also necessary to look beyond the narrow focus of a few model organisms, and to thoughtfully embrace a wider selection of eukaryotic diversity. Over the past few years, my lab has studied the genomes and mitochondrial homologues (mitosomes and hydrogenosomes) of parasitic protozoa that represent significant health hazards in both the developed and developing world.  These microbial eukaryotes will provide the model systems for investigations which aim to deliver major progress in understanding the importance of lateral gene transfer for eukaryotic genome origins and flux, for understanding how parasites exploit their host cells, and for identifying the essential functions of organelles related to mitochondria, which now appear to be vital components of all eukaryotic cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flexible object manipulation based on statistical learning and topological representations' under Seventh Framework.

assistant: **Concept**

A vision for the future are autonomous and semi-autonomous systems that perform complex tasks safely and robustly in interaction with humans and the environment.  The action of such a system needs to be carefully planned and executed, taking into account the available sensory feedback and knowledge about the environment. Many of the existing approaches view motion planning as a geometrical problem, not taking the uncertainty into account.  Our goal is to study how different type of representations and algorithms from the area of machine learning and classical mathematics can be used to solve some of the open problems in the area of action recognition and action generation.FLEXBOT will explore how how topological representations can be used for an integrated approach toward i) vision based understanding of complex human hand motion, ii) mapping and control of robotics hands and iii) integrating the topological representations with models for high-level task encoding and planning.Our research opens for new and important areas scientifically and technologically. Scientifically, we push for new way of thinking in an area that has traditionally been born from mechanical  modeling of bodies. Technologically, we will provide methods plausible for evaluation of new designs of robotic and prosthetic hands.  Further development of machine learning and computer vision methods will allow for scene understanding that goes beyond the assumption of worlds of rigid bodies, including complex objects such as hands.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular and genetic characterization of nitrate respiration in bradyrhizobium japonicum' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Denitrification is a key process in the biochemical N cycle in the biosphere, by which inorganic nitrogen is converted into molecular nitrogen.  Bacteria of the genus Bradyrhizobium are well-known for their ability t fix dinitrogen both in free-living and symbiotic associations with legumes. They are also able to denitrify, so that they may grow under anaerobic conditions with nitrate as the only nitrogen source. Two respiratory nitrate reductases from B. japonicum have been purified and characterized and mutants unable to grow at low 02 tension in the presence of nitrate have been identified.  It is proposed to undertake a molecular characterization of the B. japonicum nitrate respiration pathway. This will involve characterizing the nitrate reductase structural genes and other genes involved in their regulation. Finally, the posible relationships between denitrification and biological nitrogen fixation will be established.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'BONUS for the Baltic Sea Science - Network of Funding Agencies'.

assistant: **Innovation**

BONUS is an ERA-NET project which brings together the key research funding organisations in all EU Member States and Associate Candidate Countries around the Baltic Sea. BONUS operates in close connection with the scientific and management actors. The aim is to form a net-work and partnership of agencies which are funding research aiming at deepening the understanding of conditions for science-based management of environmental issues in the Baltic Sea. The aim is to gradually and systematically create conditions for a joint Baltic Sea research and researcher training programme. The 'status quo' in ongoing research, research funding, marine research programme management and infrastructures is examined and the necessary communication and networking tools are established. The needs and conditions of a joint research programme from scientific and administrative point of view are examined. The integration of the Associate Candidate Countries to the common funding scheme is considered in one of the proposed tasks. Finally, an Action Plan for creating joint research programmes, including all jointly agreed procedures of programme management and aspects of common use of marine research infrastructure is produced. An additional activity is the development of a common postgraduate training scheme. The consortium is composed of altogether 11 partners: 10 partners from 8 countries and one international organisation. In addition, BONUS links 7 funding organisations as associated members, which increases the number on involved organisations to 18 and countries to 9.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Enzyme technology for Lean and Green food processing'.

assistant: **Innovation**

Plant material, including industrial vastes from grain production and the juice and vegetable oil industry, is a rich source for valuable functional ingredients for processed foods. Processing of relevant agricultural vaste and product refinery needs, however, rethinking, as it often depends on use of chemical reagents of environmental concern and of harsh reaction conditions with high energy demands. Large requirement of process water adds further to the environmental load. The LeanGreenFood Initial Training Network will focus on solutions to reduce consumption of water and energy, both scarce resources in the future. Carbohydrate and peptide processing to yield value-added food ingredients will be based on the use of mono-component enzymes and on technology developed for highly concentrated solution systems. The LeanGreenFood.network will train 13 ESR’s and 4 ER’s to develop and implement new enzyme-based technology for future development of a more sustainable production. The training will include development and use of specific on-line analytical methods for process monitoring. The use of mechanical treatment and high-pressure tuning of enzymes for process optimization will open up for further process control. The training programme and conferences will be open for participants from outside the Network with the perspective of training a new generation of food scientists.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Flexible large area display using nanotechnology light emitting devices', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The NANOPAGE project will focus on the development of a flexible large area display made by assembly of microCRTs into a polymer canvas. Those microCRTs are millimetre size cold-emission cathode ray tubes, used as elementary color dots, 3 microCRTs, red, green and blue, making a complete pixel. Those microCRTs use nanometer scale Carbon Nanotubes (CNT) as cold electron sources. The first type of microCRTs, with a 3 mm diameter, will allow building a 4x3 m panel with SVGA (800 x600) resolution.The main tasks are:- to industrialize a low-cost lab proven technique for controlled growth of vertically aligned CNTs.- to develop highly automated assembly techniques to manufacture the miniature vacuum tubes in large quantities and to mount them on the polymer substrate.- to develop an innovative addressing scheme, where a miniature microchip is mounted on each microCRT.This scheme allows to:- bend, cut or repair the display as there is no peripheral drivers- control locally the microCRTs light emission- correct non uniformities due to manufacturing or aging.Cost targets are integral part of the project objectives, to insure a very competitive pricing of the end product. We will carefully consider the product recycling and avoid any use of lead, mercury or other toxic materials. It is expected that the low cost and flexibility of such a display product will significantly increase the large area display market as it should open up new applications which are today limited by the performance of existing large area display solutions.As those microCRTs are small tubes, manufacturing does not require a large size reactor, oven or other expensive equipment, so the capital investment for a complete line is moderate and modular, adjustable to the production volume. This limited and progr