RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Tracking the Genetic Origins of the First Americans'.

assistant: **Concept**

Ancient DNA techniques will be applied to over 150 human remains from the US and Mexico corresponding to paleoamerican and amerindian populations in order to address the origin and diversification of the first inhabitants of the Americas. Second generation DNA sequencing technologies will be used to yield large amounts of genetic data of Amerindians from across Mexico and the Southwest United States. This will include the well known and controversial extinct Pericu population from the Baja California Peninsula and the Clovis site of Anzick, Montana. Complete mitochondrial genomes and nuclear SNPs will be used to compare the genetics of the presumably isolated Pericu population with contemporaneous Amerindians. In addition the genetic data of these populations will also be compared to those of the first paleoamericans (Clovis). Initially all samples will be screened using conventional PCR and amplicon sequencing on the Roche FLX platform for short fragments within the mitochondrial hypervariable region. These fragments, predominantly spanning HVS1, will be used to both assign a preliminary haplotype to each sample, and identify samples of particular interest (based on which haplogroups they fall into). Subsequently, the dataset will be partitioned into two groups. Those samples of particular interest will have the complete mitochondrial DNA genome sequenced using novel targeted-capture based sequencing. This is the first large scale genetic study to address this subject and the data obtained will be used to test different hypotheses about the colonization of America, such as the origin of the Clovis, possible population replacement events and therefore about who were the direct ancestors of the first Amerinidians.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DECODING THE NEURAL CODE OF HUMAN MOVEMENTS FOR A NEW GENERATION OF MAN-MACHINE INTERFACES' (DEMOVE).

assistant: **Innovation**

The generation of a movement is the combination of discrete events (action potentials) generated in the brain, spinal cord, nerves, and muscles. These discrete events are the result of ion exchanges across membranes, electrochemical mechanisms, and active ion pumping through energy expenditure. The ensemble of spike trains discharged in the various parts of the neuromuscular system constitutes the neural code for movements. Recording and interpretation of this code provides the means for decoding the motor system. The main limitation in the investigation of the motor system is the current impossibility of detecting and processing in the intact human, during natural movements, the activity of a sufficiently large number of motor neurons and sensory afferents (neural code) to associate a functional meaning to the cellular mechanisms that ultimately determine a movement. This limitation in turn impedes to answer to many fundamental questions on the control of human movements. These questions have tremendous implications in the development of man-machine interface systems. In this project, we propose the development of advanced electrode systems for in-vivo electrophysiological recordings from nerves and muscles in humans and new computational methods/models for extracting functionally significant information on human movement from these recordings. The highly innovative focus is that of providing the link between the cellular mechanisms and the behavior of the whole motor system in the intact human, i.e. to build the bridge between the neural and functional understanding of movement. On the basis of these new technologies, we aim at answering open questions in movement neuroscience and using novel principles for man-machine interaction. Specific applications in man-machine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reconstructing the coordinated self-assembly of a bacterial nanomachine' to be submitted under Horizon 2020.

assistant: **Abstract**

Life has evolved diverse protein machines and bacteria provide many fascinating examples. Despite being unicellular organisms of relatively small size, bacteria produce sophisticated nanomachines with a high degree of self-organization. The motility organelle of bacteria, the flagellum, is a prime example of complex bacterial nanomachines. Flagella are by far the most prominent extracellular structures known in bacteria and made through self-assembly of several dozen different kinds of proteins and thus represents an ideal model system to study sub-cellular compartmentalization and self-organization.  The flagellum can function as a macromolecular motility machine only if its many building blocks assemble in a coordinated manner. However, previous studies have focused on phenotypic and genetic analyses, or the characterization of isolated sub-components. Crucially, how bacteria orchestrate the many different cellular processes in time and space in order to construct a functional motility organelle remains enigmatic.   The present proposal constitutes a comprehensive research program with the aim to obtain a holistic understanding of the underlying principles that allow bacteria to control and coordinate the simultaneous self-assembly processes of several multi-component nanomachines within a single cell. Towards this goal, we will combine for the first time the visualization of the dynamic self-assembly of individual flagella with quantitative single-cell gene expression analyses, re-engineering of the genetic network and biophysical modeling in order to develop a biophysical model of flagella self-assembly.   This novel, integrative approach will allow us to move beyond the classical, descriptive characterization of protein complexes towards an engineering-type underst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of perisomatic inhibition on prefrontal cortex neurons in gamma oscillations and cognitive flexibility' in the context of a Horizon 2020 call.

assistant: **Objectives**

Dysfunction of the prefrontal cortex (PFC) contributes to cognitive deficits that represent the primary cause of disability associated with schizophrenia. However, currently available antipsychotic medications are only minimally effective for cognitive symptoms, demonstrating the need for better therapeutic targets. Treatments for cognitive deficits in schizophrenia remain underdeveloped in large part because the relevant physiological mechanisms remain unclear.A major hypothesis is that in schizophrenia, GABAergic interneuron abnormalities, notably fast-spiking interneurons that express parvalbumin (PV) and generate gamma oscillations, disrupt PFC-dependent cognition in schizophrenia. PV interneurons are critical for synchronization of neural activity, but exactly how these oscillations are regulated remain unknown. Perisomatic inhibition from cholecystokinin (CCK) interneurons can alter properties of PV networks by regulating the likelihood to generate oscillations or to affect the frequency, duration, synchrony, spatial extent, or other properties of these oscillations. Yet their role in PFC is elusive and surprisingly little is known about their functional role in the emergence of gamma activity and cognition despite their structural control over their postsynaptic partners. My research plan has two aims: to characterize the circuit-specific activity dynamics of CCK interneurons in 1) PFC gamma oscillations and 2) cognition. I will use a multidisciplinary approach, combining in vitro and in vivo physiology, viral and transgenics strategies, pharmacology, fiber photometry, 2-photon imaging, and optogenetics to provide a more specific mechanistic framework for therapeutic intervention. I hypothesize that CCK interneurons significantly control the perisomatic region of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scaling-up NCD Interventions in South East Asia' under Horizon 2020.

assistant: **Concept**

The SUNI-SEA project aims to validate effective scaling-up strategies of evidence-based diabetes and hypertension prevention and management programmes, and to enhance sustainable action for the achievement of the Sustainable Development Goals, based on experiences in South-East Asia. The burden of non-communicable diseases (NCDs), such as hypertension and diabetes, is increasing in low- and middle-income countries. Indonesia, Myanmar and Vietnam have national or large-scale evidence-based programmes to prevent diabetes and hypertension, detect people at risk and treat patients. By creating synergies in financing (health insurance and public funding), use of international standards (WHO-PEN protocols and local guidelines), community involvement (individuals and groups) and use of ICT (different apps), the three countries link NCD prevention and control to poverty alleviation and social security. Within these excellent living labs, the consortium will apply a comparative effectiveness research with a participatory approach – research with people, not on people. The project will define the critical success factors for scaling-up hypertension and diabetes prevention and management measures by validating a) the contextual factors for effective and efficient implementation; b) the core components of community-based and health facility-based interventions; c) the most cost-effective and sustainable scaling-up strategies. The project will create training and learning materials, draw lessons learned from these three countries and provide a cost-effective implementation and scaling-up model for worldwide implementation of NCD interventions. Through engaging all stakeholders, SUNI-SEA will contribute to the Global Alliance for Chronic Diseases evidence base that can be used to imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Energy-generating synthetic tissues', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Synthetic tissues are of great scientific and technological importance as they might not only enable purpose-driven complementation of natural tissue functionalities to repair or replace dysfunctional or damaged tissues, but also allow the engineering of intelligent artificial biomaterials with features that do not exist in nature. Main limitations of current synthetic tissues based on lipid-coated droplet networks are a low material durability over the long-term, a low availability of diverse functions (apart from electrical communication and macroscopic deformation) and a lack of control capacity using external signals in a reversible manner. The main goal of this proposed project is the engineering of a novel light-controllable synthetic tissue capable of generating energy, which consists of a printed network of polymer-coated droplets that carry specific enzymes within distinct droplets. Such energy-generating synthetic tissues convert chemical energy into electrical energy, and might therefore be applied as miniature bio-batteries to power implanted medical devices such as pacemaker in human patients. Engineering of synthetic cells and bio-batteries are a current focus of the 2017 Work Programme of European Commission and will advance the development of industrial biotechnology, which is one of Key Enabling Technologies of European industrial policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The effects of leather processing on area yield' in the context of a Fourth Framework call.

assistant: **Objectives**

Area yield is essential to the leather industry. Tanners purchase skins and hides, the raw material of leather making, by weight and then sell the processed leather by area. Leather manufacture results in a considerable number of dimensional changes due to chemical interactions between process chemicals and the substrate. These changes have direct commercial implications to the tanner and are therefore great importance if profit margins are to be maintained. Many techniques, instruments and processes have been implemented into the leather industry so as to ensure high yields are obtained from raw material. Little consideration or planning has been taken during these implementations and they do not address the problems of process control, an issue shown to be of great importance to area yield. This project therefore aims to Investigate each step of the leather production process to determine which parameters most effect area yield, Evaluate in particular the drying and post tanning operations, including comparisons of each of the more common drying methods. Determine the effects of humectants on retention of area yield. Produce the best practices for production scheduling to obtain maximum area yield. Sench mark the leather production in terms of area yield.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Expanding the European Future Internet Community' in the context of a Seventh Framework call.

assistant: **Objectives**

In order to used the funding for R&D activities on Future Internet in an efficient way and to ensure that reasonable results will correspond to the investments, it is necessary to establish tight and coordinated partnership among all relevant European stakeholder in the sector. To realise it, the European Future Internet Initiative is ready to involve the stakeholders into discussions on definition of the R&D objectives related to the Future Internet, to ensure coverage of all for the investigations relevant topics, and to encourage their participation in related projects. The first step forward establishment of this coordinated partnership is enlargement of the European Future Internet Initiative into a broad European community, which is the main goal of EX-FI project.<br/>The enlargement of the European Future Internet Initiative community will be carried in accordance with the scope and objectives as well as initial planning of a European PPP (Public Private Partnership) on Future Internet. Thus, work done and contributions made by the enlarged Future Internet community can be efficiently integrated within overall PPP activities, in particular in its strategic documents presenting the major R&D areas to be addressed by specific Future Internet calls. The EX-FI project will establish a required partnership scheme and facilitate necessary discussions among the stakeholders, in order to specify a number of usage areas and to indentify major R&D challenges. The initial usage areas in discussion are: Content delivery and production, eHealth, Smart energy grid, Utilities, environment, and enhanced collaboration, as well as Transport, mobility, and logistics.<br/>The main project objectives are:- Identification of Future Internet usage areas- Definition of related R&D chall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Realising curved surfaces with optical quality by means of nano-precision grinding based on ELID technology' under Fifth Framework.

assistant: **Concept**

Title: Realising Curved Surfaces with Optical Quality by means of Nano-Precison Grinding based on ELID Technology (Nano Grind) Objectives: Nano Grind aims at producing cheap, smooth and curved optical surfaces (in glass, ceramics or hard metal) using an innovative grinding machine tool with electrolytic in-line dressing (ELID). Nano Grind will give a significant machining cost reduction with equal specs on dimensional accuracy and surface quality. This will be realized by a faster overall production process for direct manufacturing and by offering longer standing moulds for replication. This will result in an important cost reduction for the end-user. Nano Grind will enable production of curved surfaces with average roughness value comparable to polishing. Nano Grind will enable production of curved surfaces with a very high dimensional accuracy. Combined with the previous objective this will allow high-precision optics with high shape accuracy. Description of the work: Nano Grind has an approach of four major R&D activities running in parallel and synchronized by horizontal activities. A first activity concentrates on free-formed products machined with ELID. Another activity investigates the fundamental nature of ELID for free formed surfaces and will develop process that is reliably applicable in industrial conditions. A major issue here is the investigation of a reliable ELID dressing counter-electrode. A third activity involves the design, manufacturing and building of a machine toll for free-form ELID resulting in curved surfaces with optical accuracy. Here an ultra-stiff nano-positioning system will be investigated. The fourth activity of the project is addressing the exploitation and dissemination of projects results. This part also implements a data management s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The New Era of Self-Care's Digitalisation. Better Health with Lower Costs More Individually.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Treatment of chronic diseases create 80% of healthcare costs in the EU, annually €115 billion. The amount is continuously rising as the population ages and chronic diseases affect 8 out of 10 people aged 65 and older. However, 50-80% of chronic diseases can be prevented by reducing the risk factors and ensuring good living environment.The breakthrough innovative eLive.care -solution combines genomic tests and several at home measurements of health (ambulatory blood pressure monitor, blood glucose, cholesterol levels, sleep cycles, blood oxygen saturation) and environment (interior air quality monitors). With the support of Artificial Intelligence, the solution guides the user to independently, medically effectively and based on individual risk-factors prevent chronic diseases and their disadvantages. With the support of eLive.care -innovation several significant chronic diseases (such as cardiovascular diseases, type 2 diabetes and sleep apnea) can be detected prior to experiencing any symptom and therefore prevented.The impacts of at home preventive care are huge. By 2025 +1.1M eLive.care -devices sold, +8.8M manual and +3.9 billion (meaningful) automatic measurements done, +60k chronicity of the disease prevented, €600M saving in healthcare costs (up to 80% savings in long-term healthcare costs), €560M revenue, and 550 direct and +2300 indirect workplaces.The solution target to the market opportunity of 3.2 billion +30-year-old middle-class consumers and TAM of €5 billion. The demand is proven with €75k pre-sales and sales funnel of €76k. The solution is currently under piloting and will be launched to the market with in-house and partner sales during 2019. eLive Ecosystem Oy has enthusiastic team of nine with core competence in medical, technical and business develop