RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Determination of the role of P. gingivalis and P. intermedia proteases in mono- and synergistic mixed microbial infections in a mouse model of periodontal disease' under Seventh Framework.

assistant: **Concept**

Periodontitis is a chronic inflammatory disease of the supporting structures of the teeth caused by a polymicrobial infection and, despite the general improvement of oral health status and advances in treatment; it continues to afflict a large percentage of adults worldwide. If morbidity caused by tooth loss due to advanced periodontitis was not enough, mounting evidence suggests a causative link between periodontal and cardiovascular diseases. It is now generally accepted that a relatively small consortium of anaerobic Gram-negative bacteria (P. gingivalis, T. denticola and T. forsythia) described as the “red complex” is strongly associated with the pathological changes in the periodontium. Each of these bacteria is well equipped with virulence factors among which, proteolytic enzymes are the best studied. In the case of P. gingivalis, gingipains were shown to significantly contribute to bacterial virulence in vivo. Proteolytic activity produced by P. intermedia may also add to the destructive potential of the red complex consortium since the presence of this bacterium strongly correlates with the presence of P. gingivalis and T. forsythia in the subgingival communities. We hypothesize that different proteases affect host defense system at different non-redundant sites and these concerted multiple assaults should lead to a significantly greater effect than the additive action of individual proteases. Therefore, we postulate that this kind of interaction occurs in the periodontal pocket and may be experimentally verified using specific mice models of periodontal disease using monomicrobial and synergistic mixed microbial infections with a combination of P. gingivalis and P. intermedia wild-type and protease-deficient mutants. Our proposed hypothesis of combined proteoly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'To PROMOTE THE ACCESS OF EUROPEAN RESEARCHERS TO THE ISIS PULSED NEUTRON FACILITY' in the context of a Fourth Framework call.

assistant: **Objectives**

ISIS is the world's most intense pulsed neutron source and is Europe's only such facility. It is instrumented with high-quality spectrometers which access the finest resolutions and the highest energy transfers, the shortest lattice parameters and the largest structural units. The spectrometers are under constant upgrade and the instrument suite is steadily expanding. Pulsed sources are now accepted world-wide as offering the greatest potential for the future development of neutron scattering and the proposed European Spallation Source will maintain Europe's  undisputed lead well into the 21st century. ISIS is 80% U.K. funded but has a number of international partners within Europe and beyond. It has operated a full international user programme for ten years with a well-developed infrastructure for all aspects of user liaison. Great emphasis is placed upon personal user support and training. The HCM programme at ISIS has allowed wide European access to non-partner countries as well as enhancing access to European partners. Particular effort has been made to attract users from all European countries. The present proposal requests 120 days access per year to ISIS, which represents -6% of the programme, together with funding for new-user training courses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biological Physics of Living Active Nematics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The growth of a bacterial colony is a fascinating example of a biological process that can be interpreted in physical terms as the interaction of a collection of elementary units - the cells - with the surrounding environment and within themselves, whereby energy is harnessed and dissipated, thus determining inherent non-equilibrium conditions. Although bacterial cells are one of the simplest forms of life, scientists have so far found difficult to build theoretical models of bacterial growth and morphology as well as to perform controlled experiments of the real systems occurring in nature. These difficulties arise from the naturally occurring conditions that are characterized by a large degree of complexity in both morphological and chemical terms.The aim of this project is to investigate through novel experimental approaches the biological physics which is at the foundation of the formation of 2D bacterial microcolony and its successive development to a 3D structure. To this purpose, several experimental techniques, from traction force microscopy, through laser ablation and soft lithography will be exploited. Furthermore, experimental results obtained from these studies will be of great relevance for the validation of numerical and theoretical models of bacterial colony morphogenesis and antibiotics exposure. The planned research activities will be carried out in one of the top research laboratory in Europe for active matter and within the wider context of École Normale Supérieure, a world renowned academic institution in the fields of statistical mechanics, soft matter and optics.This project aims thus at providing fundamental insights into the development of early stages of bacterial community formation, trying to establish what physical parameters related to the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '50 KW GRID CONNECTED PV GENERATOR ON A STORAGE PLANT OF URBAN RESIDUALS' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

50 KW grid connected PV ROOF for a building where arrives the waste of 3500 apartments with a innovative system : pneumatics conduction tubes under the streets which avoid the waste containers and trucks to empty them.The buidling will be environmental representative with a nice design to be showed to the population. The building will be design with a priority, the best solar PV integration. It will be south orientation with 30 degrees tilt; hexagon plant, only one big roof made with PV panels.1. innovation technology :- Market innovation : the municipality wants a nice building to show the solar panels, with hexagonal plant to be an attraction to the eye" PV panels are the only roof in the building. This is going to be built up for an architect thinking in the best orientation and integration of the solar system. No windows, chimneys, etc are necessary on the roof, so it will be a good bank of test for a big PV panel. Plastic and aluminium construction elements will be used.- DC wiring connections between the panels are incorporated in the structures making it a prefabricated construction element.- The inverter with grid connection will be last technology using IGBT.2. context in which the technology is operating- The project will be an important social service for 3500 families of Alcobendas.- Centralsug will take this first experience as standard for many projects they do like this.- First time PV energy and waste pneumatic collection are together.3. economic aspects of the technology :- Price reduction : 7,44 ECU/W system and 4,14 ECU/W PV modules.- Costs reduction due to the integration of the PV modules into only one large area of roof which have no obstruction such as windows, chimneys, etc., allowing for modular construction and simplified assembly and maintenan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'INCORPORATE sustainable structures for Energy Efficiency projects in Austrian Smart Cities' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

IncorporatEE project aims to realise EUR 60 million of total investments (EUR 32 million in energy-related measures) in major renovations, improvement of building services and installation of renewable energy sources in public buildings in the city of Salzburg and Villach. These savings will not only be calculated at the design stage, but will be guaranteed by an innovative quality management process up to commissioning. In this way, energy savings of 55% and CO2 savings of 65% can be achieved in building operation during comprehensive renovations, which means an increase of around 30 percentage points compared to previous renovations.In order to achieve this goal, it is necessary to turn not just one but many set screws. The new Performance-Based-Renovation-Package (PeBaRePa) is the sum total of these set screws for renovations. This package is designed to ensure the implementation of performance-based objectives all the way through to operation. This package comprises the following components:- Establishment and training of a dedicated organisational unit in the cities responsible for implementing energy performance quality assurance- Developing internal financing models within the city in order to be able to finance investments in energy-efficient renovations in the long term- Development of innovative, performance-related contracts for planners to provide financial incentives to plan and implement high energy performance- Development of a catalogue for sustainable refurbishment of public buildings specifically for the requirements and specifications of the participating cities- Development and adaptation of a quality assurance process from planning to commissioning of buildings- Development of business models for energy communities for photovoltaics during roof refu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Product development and innovation in shipbuilding'.

assistant: **Innovation**

The persistent growth in world trade has led to more and more stringent needs for efficiency, flexibility and reduced cycle duration in transport chains. Additional influence on these developments is exerted through the urge to bring about a cargo shift from road transport to waterborne transport in Europe, thereby reducing road congestion and the impact on the environment. Today the shipbuilding industry constitutes an important sector in Europe's industry in acting as an integrator of different technologies. It also plays an important role in implementing EC-policies on transport, environmental sustainability and competitive and sustainable growth. In June 1996 the European Maritime Industries Forum (MIF), presented The Maritime Industry R&D Master Plan which addressed the R&D needs in the maritime field and indicated its key technological priority areas (RPA's). The shipbuilding industry, led by COREDES (the R&D Committee of the European Shipbuilders Association/CESA) started an R&D Structuring Action devoted to the coordination of the Master Plan implementation. The Master Plan identified four research priority areas (RPA's). The present network stems from RPA3 and is termed PROduct Development and Innovation in R&D (PRODIS) . The aim of this Thematic Network is the co-ordination of the R&D activities relevant to product development and innovation. The present network makes, by linking different national programmes and projects, more efficient use of the available funding. For the purpose of involving various suppliers and end users, a reference framework will be established within the network partnership. The framework will consist of five (4) integrated thematic areas and one integrating area. The integrated areas (Hydrodynamics, Hull structures, Power plants and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Elite Leadership Positions In The Emerging Second Generation' (ELITES).

assistant: **Innovation**

Research in the field of Ethnic and Migration Studies has predominantly focused on immigrants (and their children) with poor educational credentials and the lowest labor market positions. A relative blind spot has been the surge and role of new elites within these populations. The central aim of the ELITES project is to examine the formation of new elites among the Turkish second generation in eight European cities (European cities with large Turkish communities) and a comparison group of elite members of native parentage of lower class background. The ELITES project analyzes differences in the pathways, resources and individual strategies that have contributed to attaining an elite position. The project looks at the impact of these new elites upon the Turkish communities, and to what extent they take up leadership positions in mainstream organisations. For this second part of the ELITES project we focus on the networks of the elite members. The Turkish second generation elite is compared with an elite of native parentage to see if findings for the second generation Turks are specific or are part of a more general pattern.For the ELITES project we use both quantitative and qualitative research methods. We will interview in-dept 240 elites members in eight European cities. The two PhD students will investigate in their subprojects the importance of respectively ethnicity and gender in the elite formation of the two groups. In the second part of the project (sub project 3) we gather information about the closest and most crucial (for their elite position) network members of the respondents. From these network members we will also gather information about their network contacts. The resulting elites network information will be analyzed quantitatively and compared across th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Quantum Interfaces and Open Systems' (QIOS).

assistant: **Innovation**

Researchers have strived to obtain control of a variety of different quantum systems, each characterized by their own distinct advantages: quantum optical systems offer excellent isolation from the environment while solid state systems allow for integrated micro-fabricated devices. At the same time nuclear spins in molecules can remain decoupled from the environment even under rather harsh conditions, and this is the basis of NMR experiments. Given these distinct advantages it is very fruitful to investigate hybrid devices merging the advantages of each of the systems. To do this it is essential to develop quantum interfaces to connect the different systems. By their very nature such quantum interfaces exchange information with their environment and are therefore open quantum systems.In this project I wish to establish a strong theoretical quantum optics group which can guide and inspire the experiments towards breaking new grounds for open quantum systems and making quantum interfaces between distinct physical systems. The objective is to develop concrete proposals for how to experimentally control and exploit the interaction of quantum systems with their surroundings and for how this can be used for quantum interfaces.The work in this project is particularly relevant for applications in quantum information processing, where the current challenge is to take the field from proof-of-principle demonstrations to truly scalable devices. Such challenge demands new interdisciplinary theoretical ideas for hybrid devices. This proposal addresses several key challenges for quantum information processing: scalable multimode quantum repeaters based on hybrid approaches, entanglement enabled quantum metrology, photonic engineering based on surface plasmons, dissipative preparation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fast determination of fatigue properties of materials beyond one billion cycles' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Many mechanical structures are submitted to repeated loadings and can break under stress lower than the ultimate tensile stress. This phenomenon is called the fatigue of materials and can be found in many industrial sectors, such as the transport industry, aeronautic industry and energy production. Fatigue design is thus crucial in engineering and it requires the precise characterization of material behavior under cyclic loadings to ensure the safety and reliability of structures throughout their life. An increase in the life span of a structure or a reduction in the number of maintenance phases leads to an increases in the number of cycles applied to this structure. It is presently common to find mechanical systems subjected to several billion cycles, in what is called the gigacycle fatigue domain. The characterization of the fatigue behavior of materials requires fatigue tests to be conducted until fracture for different stress amplitudes. One problem with this method is the test duration, which becomes excessive and beyond possible, particularly for a very high number of cycles. The goal of FastMat is to develop a new method that reduces considerably the duration of fatigue characterization. This method involves the use of only short interrupted tests coupled with a self-heating measurement to characterize the fatigue behavior for very low stress amplitudes. The scientific objective is to develop simultaneously experimental and numerical tools for the fast determination of fatigue behavior. The experimental approach will be developed to estimate simultaneously the dissipation and the stored energy, which directly reflect fatigue damage. For the numerical approach, discrete dislocation dynamics simulations will be developed to establish links between the fatigue damag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Component-based synthesis of Waixenicin A enables TRPM7 inhibitor development' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Waixenicin A (WaixA) is an exceptionally potent, selective inhibitor of TRPM7: the key regulator of cellular Mg(II) homeostasis. As such, it holds promise as a lead compound for treating diseases associated with aberrant TRPM7 activity, such as cancer and neuronal disorders. However, limited access to WaixA has prevented in-depth investigation of its mode of action and pharmacology. This proposal addresses these limitations by providing scalable synthetic access to WaixA (WP1), deciphering its mode of action (WP2), and developing analogs of WaixA with improved efficacy (WP3).WP1 will develop a component-based synthesis of WaixA that constructs the strained (E)-cyclononene via efficient annellation of a linear precursor onto a cyclohexenone fragment using radical or ionic conjugate addition-trapping sequences. WP2 aims to unravel WaixA’s mode of action and binding site through cellular inhibition assays of TRPM7 and cryo-EM structure determination, and proposes an unprecedented, doubly covalent mechanism. WP3 targets second-generation inhibitors of TRPM7 with improved efficacy. These analogs will be synthesised via late-stage diversification in WaixA’s western fragment, or through rigidification of the proposed allylic acetate-pharmacophore or the cyclononene skeleton. Combined, WAIXYN represents the first integrated research effort to study and improve upon the fascinating pharmacophore of WaixA, providing cornerstones for future TRPM7 inhibitor development that can help study and treat diseases associated with aberrant TRPM7 activity in cells and in vivo. A practical synthetic platform to WaixA will enable access to other xenicin natural products and expand the narrow synthetic repertoire for constructing medium-sized carbocycles.WAIXYN will provide extensive training