RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Filterlex is a unique, full-body, embolic protection device for Trans-catheter Aortic Valve Implantation procedures.'.

assistant: **Innovation**

Aortic stenosis is the most common and most serious heart valve problem. It leads to shortness of breath, angina, blackouts and in severe cases: sudden death. This condition presents 2-9% of general population over 65 years old. Trans-catheter aortic valve implantation (TAVI) is a standard therapeutic option for patients with severe aortic stenosis condition. However, during maneuvering, positioning and deployment of the new valve using catheter, embolic particles are released from the natural aortic valve to the vascular system, making TAVI procedure unsafe. Filterlex is a novel intra-aortic protection device for deflecting, capturing and removing embolic particles during catheter-based left-heart procedures. Easily positioned, deployed and retrieved, the device provides complete celebral protection during valve implantation. The device provides full body protection from embolic showers, and thus, makes TAVI procedure safe.


**Keywords:** embolic protection device, EPD, TAVI, aortic stenosis, heart, heart valve, stroke, elderly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ENFIELD: European Lighthouse to Manifest Trustworthy and Green AI' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

ENFIELD will create a unique European Centre of Excellence that excels the fundamental research in the scientific pillars of Adaptive, Green, Human-Centric, and Trustworthy AI that are new, strategic and of paramount importance to successful AI development, deployment, and acceptance in Europe and will further advance the research within verticals of healthcare, energy, manufacturing and space by attracting the best talents, technologies and resources from world-class research and industry players in Europe and by carrying out top-level research activities in synchronisation with industry challenges to reinforce a competitive EU position in AI and create significant socio-economic impact for the benefit of European citizens and businesses. ENFIELD will develop, maintain, scale-up and sustain a vibrant European network on AI composed of 30 consortium members from 18 countries, including top-level education and research organisations, large scale businesses, SMEs, and public sector representatives jointly addressing critical issues of research and innovation frontiers in this new topic of the European AI Lighthouse.ENFIELD will provide high impact outputs such as >75 unique AI solutions (algorithms, methods, simulations, services, data sets and prototypes), 180 scientific high-impact publications and 200 peer-reviewed presentations, four strategic documents, namely the Common Research Roadmap and Vision, the dynamic Safety and Security Risk Assessment Framework, the White Paper and the Gender and Ethics Framework. The exchange and innovation schemes planned in Open Calls, which will grant financial support to >76 individual researchers and 18 small-scale projects, education, and training activities such as summer schools and hackathons, and a set of well-designed outreach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multiregional rtfMRI Neurofeedback for the Prevention of Alzheimer's Disease' under Horizon 2020.

assistant: **Concept**

This project aims at predicting early cognitive decline using a neurofeedback performance endophenotype based on realtime functional magnetic resonance imaging in a population at risk for Alzheimer’s Disease (AD). It has been proven that AD biomarkers change decades before the development of symptoms. In addition, there is a lack of robust hypersensitive methods capable of predicting impending cognitive decline in healthy subjects at risk. This constitutes a crucial obstacle for the implementation of AD prevention trials. To address this, we will identify and characterize a novel neurofeedback performance endophenotype in a subsample from a cohort of 2743 cognitively healthy volunteers at risk for AD. This will be based on state-of-the-art neuroimaging technology, in combination with a novel sensitive neuropsychological test that detects subtle alterations in episodic memory, which has been validated for our cohort. Then, we will evaluate the impact on our newly developed neurofeedback performance endophenotype of factors known to be related to AD such as various clinical and lifestyle variables, amyloid deposition, genetic background (including, but not restricted to APOE4) and most importantly cognitive reserve. A specific aim is to test the hypothesis that neurofeedback performance can become a reliable proxy to measure cognitive reserve. Finally, we will develop a novel statistical predictive model, featuring all the relevant genetic and clinical variables and will assess the capacity of neurofeedback performance for predicting impending cognitive decline during a two-year period in AD descendants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Twentieth-Century International Economic Thinking, and the Complex History of Globalization', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Today globalization, the integration of the world's economies, is blamed for crises of corporate excess, gaping economic inequality and revived populist nationalisms; to understand its complex history is more pressing than ever. ECOINT advances an innovative approach to the study of the struggles over economic ideas that have fashioned the paths to globalization. It shifts our focus from international economic thought as an unanchored field of ideas, to international economic thinking, generated in and through institutional sites distinctive to the 20th century: intergovernmental organisations and associated international non-governmental organisations. ECOINT adds to the history of globalization important but understudied economic thinkers, namely mid-level and non-intellectual intellectuals, many of them women, working with and in these organizations, from 1919 until 2001. Hence, ECOINT provides a nuanced history of twentieth century international economic thinking and imaginaries, while making a unique contribution to understanding of the international 20th century. Above and beyond, ECOINT will ask: What difference did women economic thinkers make in the course of globalization? And what was the role of business, operating through INGOs? Using largely neglected private and public archives, ECOINT will produce a capstone global history of international economic thinking, and social history of women economic thinkers in international institutions. It will capture the extent and breadth of international economic thinking at major IGOs particularly the UN Regional Economic Commissions in Europe, Latin America, Asia and the Pacific, and Africaand the INGOs the International Federation of Business and Professional Women and International Chamber of Commerce. Within five y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Timing and plasticity in the olivo-cerebellar system' (CEREBNET) targeting Seventh Framework.

assistant: **Abstract**

Training young researchers to form the new generation of scientists is a must for our society. In this project we will use a multidisciplinary approach to investigate neuronal and circuit functions in the cerebellar network, which plays a critical role in sensori-motor control and is probably also involved in higher cognitive functions. The project will focus on timing and plasticity in the network. Recent results, largely achieved in our own groups, have shown indeed that timing and plasticity play a critical role in determining the computational properties of the circuit. Different groups will be involved in investigating these processes in the granular layer, the molecular layer, the deep cerebellar nuclei and the inferior olive and particular emphasis will be given to attempts at reconstructing hypotheses on the link between these circuit components. We will therefore employ and develop new technologies including various applications of patch-clamping, imaging and mathematical modeling, as well as molecular biology and behavioral analysis in mutant mice. The project is based on a previous extensive scientific interchange between the participating groups, which have already developed collaborative activities in the past. We envisage to employ young scientists in PhD and postdoctoral programs (16 ESR and 3 ER) and to promote their interchange among our laboratories, both by developing collaborative investigations and by organizing workshops and training courses on scientific issues, techniques, and general skills. The participation of industries will ensure research and training on productive aspects and on management of science, strongly improving the effectiveness of the network in preparing new scientific operators and leaders in the emerging field of Cellular/Syst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Scaffolds for alternative delivery' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The SME-based SADEL consortium intends to develop the first generation of oral bio-therapeutics tackling disease targets in the digestive tract, by making optimal use of the Nanofitin (Nf) protein scaffold. Nf based drugs will progress through routes not travelled by antibodies while interacting with targets not modulated by chemical compounds.Existing Nf hits against validated targets will progress to the preparation of Phase I Clinical trials in Ulcerative Colitis (UC). To achieve this, SADEL assembles a virtual biopharmaceutical company with SMEs (70%), academics, clinicians and pharma industry with all cutting-edge skills: production (including GMP), analytics, formulation, preclinical and clinical development, up to licensing.Nfs are small (optimal tissue penetration), exhibit strong resistance to pH and human intestinal fluids (long half-life in digestive track) and their high affinity implies low effective concentration. They also demonstrate strong potential for optimizing pharmacological properties, including reducing immunogenicity.The Nf based drugs will be administered orally, reducing the systemic exposure and avoiding the safety issues reported with systemic administration of antibodies. This requires large quantities of proteins for frequent administration. Nfs are produced in bacterial systems for which GMP-compliant processes are broadly adopted in the industry, with a low cost of goods. The resulting proteins will be formulated for optimal release at the sites of action.The project is designed to address unmet technical challenges while avoiding external risks beyond those related to the scaffold behaviour itself. All additional elements are chosen for documented validation, from targets to evaluation protocols.Achieving SADEL aims will solve unmet pat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Microresonator based Frequency Comb Generators' to be submitted under Seventh Framework.

assistant: **Abstract**

Optical frequency combs have revolutionized optical frequency metrology in just a few years. They have made it possible to directly count light field oscillations of several 100 million cycles per second. Traditionally they have been created with mode locked ultra short pulse lasers. In this project we propose to investigate frequency comb generation based on monolithic micro resonators. As recently demonstarted by the consortium they can create combs with a conveniently high mode spacing suitlable for many different applications. The scientific objective of the collaboration is to develop micro resonators based frequency combs using silica on chip micro resonators and crystalline micro resonators and test them in two applications, as a reference oscillator and as a calibration tool for spectrographs. The partners are the Swiss Federal Institute of Technology in Lausanne (Switzerland) and Menlo Systems GmbH in Germany.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Multi-tier Architecture for Distributed Interactive SimulatiON'.

assistant: **Concept**

The objective of the MADISON project is to develop and implement an architecture, based on the standardization efforts in the fields of HLA and MPEG-4 and in the work of the dis-java-vrml standardization group, which can be employed for the design, development and deployment of short-range multiuser simulation environments and for the provision of new types of services based on semi-real content. The MADISON project brings together complementary expertise from 7 different organisations, which cover all the different technical facets of the project: an MPEG-4 expert, a 3-D graphics expert, a network acceleration expert, a behaviour modelling expert, a hardware expert, a software developer and systems integrator, and a digital TV provider.Objectives: Network latency continues to be the main barrier for the deployment of distributed interactive simulation (DIS) applications. Partial solutions exist for particular domains, like military scenarios, but the need exists for a complete architecture which integrates the different standardisation efforts and addresses the requirements of highly interactive, consumer-oriented DIS scenarios.The objective of the MADISON project is to develop and implement such an architecture. To this end, the project will develop:1) A high-performance FPGA-based MPEG-4 render 2) A set-top box to be used as a DIS-client terminal 3) An optimised MPEG-4/DIS network acceleration middleware 4) A DIS-oriented simulation server, 5) A set of methods and tools suitable for describing all behavioural aspects of DIS.Having defined the architecture and developed the different components, the architecture will be tested deploying the system in a broadcast-type pilot.Work description:The workplan is divided into three main phases:PHASE I: Definition of the MADIS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Model City. Drivers and Mechanisms  of Long-term Urban Evolution and Resilience' (TheModelCity).

assistant: **Innovation**

The past provides the most extensive and comprehensive record of the spectrum of human behaviours, adaptations and responses to change available to us. Its potential as an enormous body of comparative material, however, has yet to be fully realised. The Model City aims to understand the drivers and mechanisms of long-term urban evolution through the study of the historical trajectories of past cities. Focusing on the question of urban resilience, “why do some cities thrive while others fail?”, it will identify factors that predict city persistence over decades and centuries and evaluate social, environmental and economic mechanisms that increase or erode urban resilience. The Model City will aggregate and synthesize large amounts of Deep Past Urban Data and apply analytical methods developed in urban studies to investigate fundamental forces governing the long-term dynamics of urban systems. By deploying a swath of formal methods such as time-series analysis, ecological measures of resilience, network science, and agent-based modelling on a large and diverse sample of past cities for which we have full evolutionary trajectories, the project will identify factors, their interactions and processes that impact urban resilience. In looking for universals, The Model City will compare three very distinctive but data-rich research areas from across the spectrum of past urban systems: Roman Empire - the first large highly integrated socio-political body in human history; Classic Mesoamerica - one of the earliest urbanised systems in tropical environments and Medieval Northern Europe - an early example of increasing globalisation driving urbanisation. This comparative study will capture past urban variability to identify the most common causes of urban collapse as well as mechan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Resistance systems and population structure of parasites' (RESIST) under Seventh Framework.

assistant: **Objectives**

The study of parasitism is important for human welfare but also addresses basic scientific questions cutting across biological disciplines. Traditionally, studies of host-parasite interactions have used various scenarios of how genotypes of the two parties interact based on well-developed theory. Yet, one of the most striking observations is the huge variation in resistance systems across organisms. We lack an appreciation of the diversity of these resistance systems and how they affect, in turn, the parasites. Here, it is proposed to investigate the hypothesis that variation in gene expression is a key element that defines an alternative, flexible and highly adaptable resistance system. The project attempts to unify genomic studies of defence mechanisms with questions of evolutionary ecology of host-parasite interactions. Therefore, the study focuses on an ecologically well-studied system of hosts (Bombus spp.) and their prevalent trypanosome infections (Crithidia). In this system, a highly genetically polymorphic parasite is kept in check by a host with seemingly conserved immune effectors (e.g. anti-microbial peptides, AMPs). Their expression varies depending on the host-parasite pairing, suggesting that variation of the synergistic mixture of expressed defence elements might be crucial and could affect parasite population structure in turn. In the project, experiments and cutting-edge molecular methods will be applied to a natural host-parasite system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hierarchical and Agile Resource Management Optimization for Networks in Smart Energy Communities' (HARMONISE) targeting Horizon Europe.

assistant: **Abstract**

The main objective of HARMONISE is to provide an End-to-End interoperable & hierarchical solution to support, encourage and scale up the transformation of traditional districts to Positive Energy Districts (PEDs) through optimal design, management, and integration in an interoperable, scalable, and replicable manner, following a user-centered approach, from the technology, business operation and social engagement perspectives, empowering the transition towards the European Super Grid . The consortium aims to offer a hierarchical approach, integrating, fog-enabled devices, co-simulation modules, open-standard interfaces, APIs, and open-standard System Structure and Parameterization (SSP) that will enable the connection with other tools and established networks. Additionally, a user engagement app will be presented to support the development of active business models, energy awareness and incentivize stakeholder involvement and entrepreneurship.  Furthermore, the consortium plans to introduce a transactive energy approach via a blockchain-based network that allows dynamic and secure smart contracts and energy exchange. HARMONISE will support the management and expansion of multisectoral PEDs, including electricity and heating networks, RES integration, mobility schemes, and energy storage problems by unifying energy transactions. HARMONISE will be demonstrated in 4 physical pilots and 1 digital pilot case that will incorporate all the other cases to a super nova Grid.


**Keywords:** Positive Energy Districts; Interoperable Tools