RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multimodal Access for Intelligent Airports' in the context of a Horizon Europe call.

assistant: **Objectives**

MAIA’s vision is that, within 5-10 years, CCAM and UAM based services will be available in an integrated manner with the airport infrastructure and the remaining access modes. AI tools and digital twins will be used for anticipating the impacts of different service configurations on the performance of airports as multimodal hubs. Aviation stakeholders will be able to make evidence-based decisions on how to implement, operate and regulate novel services in a way they improve passenger experience, increase capacity and help reach sustainability goals. The goal of MAIA is to develop a set of data analytics and modelling tools to support the evidence-based design and implementation of multimodal airport access solutions based on two passenger mobility innovations: shared autonomous vehicle fleets and unmanned aerial vehicle fleets. MAIA tools will monitor and anticipate passenger behaviour changes due to these new options, optimise vehicle dispatching under multimodal disruptions and recommend appropriate locations for vertiports, with the aim of maximising the contribution of these mobility innovations to the competitiveness and sustainability of the European aviation sector. The specific objectives of MAIA are (i) identify the opportunities and risks associated with passenger mobility innovations in a multimodal airport access context; (ii) develop MAIA-Engine, a toolset for a passenger-centric design and implementation of innovative multimodal airport access services, which includes new methods and tools for predicting passenger behaviour; (iii) develop MAIA-CCAM, a vehicle dispatching tool to support the operation of Shared Autonomous Vehicle (SAV) fleets in the airport access, able to mitigate multimodal disruption impacts; (iv) develop MAIA-UAM, a vertiport site selec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The evolution of host manipulation by bacteriophage.' to be submitted under Horizon Europe.

assistant: **Abstract**

The idea of parasite manipulation is well known in animal behaviour, with famous examples like the cordyceps ?zombie? fungus of ants. Yet, the most abundant and diverse parasites on earth do not target animals but rather bacteria. They are the bacteriophages, or phages. My hypothesis is that it is in phages that we will find the most important examples of parasite manipulation, examples that will help us both understand and control bacteria, and their impacts. I will focus on the recently-discovered Regulatory Switch (RS) phage, which reversibly excise and reintegrate into the bacterial chromosome to shift the host between different physiological states. I, and others, have shown that RS phages influence a wide variety of bacterial traits including sporulation, biofilm formation, mutation rates or bacteriocin production. However, we do not understand when, how or why these viruses cause such large changes to bacterial behavior. The goal of my project, therefore, is to understand how and why RS phage evolve as a new candidate model of parasite manipulation. Specifcally, I will answer: 1) When and how do RS phages alter host behavior? 2) What is the molecular basis for the effects of RS phage? 3) Why have RS phage evoved to change bacterial behaviours, and is there evidence of counter strategies in their bacterial hosts? I will work with the bacterium Bacillus subtilis, which is strongly affected by RS phage and a model organism, allowing me to employ the very latest molecular methods. My goal is to demonstrate that parasite manipulation is a major factor in the ecology and evolution of bacteria, whereby many bacteria are essentially puppets of their phage masters. Understanding how phage achieve this manipulation also has the potential for broad impacts in an era when th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Broadband trial integration' under Fourth Framework.

assistant: **Concept**

Main Objective BTI will demonstrate the role of quality of service (QoS) on IP over ATM for optimising the requirements for network resources and improving the perception of internet services offered to users. The project will develop an integrated IPv6 and switched ATM network with multicast capabilities and well defined QoS support of user controlled bandwidth and delay. The effect of network performance on the perception of the user with QoS control will be evaluated using educational applications adapted for the project. Technical Approach BTI will enhance simple PVC based ATM networks with QoS support by integrating IPv6 and ATM in the existing field trials of the project Broadbandloop (AC038) being carried out in Portugal, Denmark and Poland. Existing educational applications will be adapted to support QoS control. Schools, universities and teachers participating in the trials will be provided with educational applications, such as telelearning. These applications will be used to evaluate the various aspects of QoS perception, and the impact of technical performance related to QoS on end user (with QoS control) satisfaction. The outcome will provide an input to the production of guidelines and standards in this area. The project has three main phases:  -Phase 1 establishes the basic technical platform at the three trial sites where applications are installed and connectivity verified. Routers with IPv6 over ATM are installed in the networks, and system integration of PIM for IPv4 with the RSVP Controlled Load Service (mapped onto the ATM UNI 3.1 CBR Service) is carried out. An inventory of QoS settings is then built (based on the IPv6 over ATM networks) that could be used to vary the QoS in the subsequent phases. International interconnections based on ISDN will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Protection against ageing in the retina', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

In the ageing population, morbidity from blinding retinal neuro degenerations represents the most feared limitation of quality of life. The predominant causes of blindness, i.e. glaucoma, ischemic diabetic retinopathy and age related macular degeneration, occur as a consequence of both specific and common pathways leading to retinal cell, mainly neuronal, loss. The global objective of PRO-AGE-RET is therefore the development of therapeutic strategies aiming at blocking the cell death process occurring in these retinal pathologies. The scientific and technical objectives of the PRO-AGE-RET project are to identify and characterise factors and mechanisms involved in retinal degeneration as a basis for the development of rational therapeutic approaches; to design methods for therapeutic intervention; and, as a perquisite, to further develop models for retinal degeneration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regulation and Function of CARD9 / BCL10 / MALT1 Signalosomes in Innate Immunity and Inflammation' in the context of a Seventh Framework call.

assistant: **Objectives**

Acute inflammation is a response to infection or tissue damage that is critical for host protection and tissue homeostasis. However, deregulated or chronic inflammation is harmful to the host and can cause multiple diseases including inflammatory bowel disease, rheumatoid arthritis, cardiovascular diseases, neuroinflammatory disease and cancer. Cells of the innate immune system sense microbial or sterile danger via pattern recognition receptors (PRRs). Subsequently, these PRRs engage intracellular signalling modules to elicit inflammatory effector mechanisms. We have recently identified the CARD9 / BCL10 / MALT1 (CBM) signalosome as a central proinflammatory signalling complex in innate immune cells. This molecular platform responds to stimuli from transmembrane SYK-coupled C-type lectin receptors and from intracellular danger sensors such as RIG-I-like helicases, NOD2 and presumably others to robustly activate NF-κB and MAPK pathways. Innate CBM signalling is engaged upon fungal, bacterial or viral recognition and upon sterile cell injury and it is essential for host protection in humans and mice. Still, it is unclear how the CARD9 / BCL10 / MALT1 signalosome is activated on a molecular level and how CBM responses are transduced to effector cascades. Moreover, although CARD9 polymorphisms are linked to various human inflammatory diseases, the cell type- and signal-specific roles of CBM signalosomes in complex diseases in vivo are unknown. Here we aim to take an integrated genetic, biochemical and in vivo approach to comprehensively dissect the regulation of the CARD9 / BCL10 / MALT1 complex in innate immunity and to define the role of this signalosome in clinically relevant inflammatory diseases. Mechanistic in vitro studies will be combined with the in vivo analysis o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Weil-étale cohomology and Deninger's dynamical system'.

assistant: **Concept**

The aim of our research proposal is to study the connections between Lichtenbaum's Weil-étale cohomology and Deninger's dynamical system. Weil-étale cohomology (respectively Deninger's program) is meant to provide an arithmetic cohomology (respectively a geometric cohomology) relevant for the study of motivic L-functions. These are two very ambitious and promising directions in arithmetic geometry, which are certainly strongly related even if these connections are not well understood. According to Deninger's program, a foliated dynamical system should be attached to an arithmetic scheme. This dynamical system would produce Deninger's conjectural cohomological formalism. On the other hand, Lichtenbaum predicts the existence of a Weil-étale cohomology theory for arithmetic schemes allowing a cohomological interpretation for the special values of the corresponding zeta functions. This conjectural Weil-étale cohomology should be the cohomology of a deeper topological structure, namely the conjectural Weil-étale topos. The Weil-étale topos is naturally defined in characteristic p while an unsatisfactory definition has been given for number rings and more generally for arithmetic schemes. This Weil-étale topos, i.e. this generalized space, turns out to be closely related to Deninger's dynamical system. We propose to use topos theory in order to study simultaneously the Weil-étale topos and Deninger's dynamical system. The insight provided by Deninger's work will be applied to obtain new results in Weil-étale cohomology. Respectively, Lichtenbaum's explicit computations will be used to obtain information on Deninger's dynamical system. The ultimate goal of this research project is to define and study the conjectural Weil-étale topos in characteristic zero. One interesting aspe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Partnership against violent radicalization in the cities' (PRACTICIES) under Horizon 2020.

assistant: **Objectives**

The project ""Partnership against violent radicalization in the cities"" (PRACTICIES) mobilizes networks of European cities, experts from the fields of humanities, political sciences, information sciences to better understand the human roots of violent radicalization and to characterize these processes starting by their origins and to build concrete tools and prevention practices. To achieve these objectives the project PRACTICIES relies on the cooperation of experience in the field of urban security in cities and expertise of national structures to fight terrorism. Our project aims to evaluate the existing procedures of registration, identification youth in the process of radicalization in an urban space. Describe and explain social course of transition to radical action, to provide concrete tools for action. For this our project will be structured in 6 work packages :Synthesis and European consensus on radicalization processes encouraging the construction of a etiology of radicalization processes and radicalization levels tipping point. Early prevention and an inclusive and civil education that will build on the implementation of concrete actions to structure against speech and human alliances against violent radicalization. Evaluation of reporting procedures, identification, treatment of people radicalized by the comparative analysis of the procedures implemented in the enforcement agencies.Fight against breaking speech and against speech. For building a breaking speech glossary in Europe (multilingual).Technological tools to design for "" practitionners "" and "" ends users"" promote the protection of youth and attempts of indoctrination encouraging characterization of sources and resources of Hate speech and radicalization.Evaluation and innovation in urban policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrating Nutrient economy in phytoplankton GENomics and Evolution' under Horizon 2020.

assistant: **Concept**

Phytoplankton support half of global primary production, fuel aquatic food webs, and drive global biogeochemical cycles. Phytoplankton transform inorganic nutrients into organic macromolecules. There is often a mismatch between the environmental availability of nitrogen (N) and phosphorus (P) and organismal requirements, which makes N and P important environmental stressors. These selective pressures affect genetic architecture and genome evolution in two ways, first as nucleic acids code for the genes responsible for nutrient uptake and second as they determine the N and P somatic requirements by defining the amino acids and nucleotides used to build proteins and RNA. The objective of INGENE is to estimate the impact of nutrients on the genomic structure and evolution of phytoplankton by following an interdisciplinary approach that combines laboratory experiments, genomics, bioinformatic analyses, and mathematical tools using ecologically important eukaryotic picoalgae as model phytoplankton organisms. Specifically, I will address the following sub-objectives: i) characterize the physiological traits and acclimation responses that define the uptake and use of P, ii) evaluate the impact of N and P availability on genetic architecture and genome evolution, iii) determine the effect of P availability on the whole genome mutation rate and spectrum, and iv) assess the links between genetic architecture and phenotypic physiological traits. Since eukaryotic picoalgae are the smallest known eukaryotic organisms, INGENE is poised to provide novel insights into our understanding of the minimal eukaryotic cellular structure. Moreover, by disentangling the effects of nutrient availability on phytoplankton at the molecular level, INGENE will improve our mechanistic understanding of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Translating innate immune receptor function into diagnostic and therapeutic applications for atherosclerosis' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The immune system has a major role in atherosclerosis and its innate and adaptive arms jointly and separately co-determine atherosclerotic disease initiation and progression. The search for approaches to modulate the inflammatory response in atherosclerotic disease is still in its infancy. Inflammatory diseases like rheumatoid arthritis (RA) have much longer been recognized as immune disorders and hence are much ahead in development of therapeutics targeting inflammation.A multidisciplinary approach will stimulate the discovery of immune modulating compounds to treat atherosclerotic disease. Thereto, the current project joins forces of three SMEs owing unique proprietary complementary technology together with four academic groups, which are actively involved in the field of cardiovascular disease and immune modulation. Research groups work dedicated to SMEs to develop new and test pre-existing lead compounds that modulate the innate or adaptive immune response and subsequent atherosclerotic disease. In addition, diagnostic markers will be exploited that reflect the severity of atherosclerotic disease based on innate receptor ligands and responsiveness, focused on TLR and NOD receptors.In work packages (WP) 1 and 2 targets for intervention, that have been discovered using an integrated genomics or proteomics approach, will be validated and antagonists constructed using both small molecule and antibody technology. WP 1 will focus on innate receptor signalling, WP 2 will address the therapeutic and diagnostic value of TLR ligands and responsiveness. In WP 3 and 4, the properties of therapeutic lead compounds and diagnostic modalities that are based on modification of the innate and adaptive immune response will be assessed using state of the art in vitro and animal model s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Computational imaging through scattering materials using speckle correlation' in the context of a Horizon Europe call.

assistant: **Objectives**

When viewed under coherent imaging conditions (e.g. laser illumination), scattering materials such as biological tissues create noise-like images known as speckle. Despite their seemingly random nature, speckle patterns have strong statistical correlation properties that are highly informative of the material producing them. These can be used to enable remarkable imaging capabilities, not possible with current state of the art, for example seeing through highly scattering layers.Unfortunately, realizing these  in practical  settings (tissue imaging, fluorescence microscopy) remains a challenge. Research efforts  are hindered by a lack of modeling tools, resulting in an incomplete understanding of speckle properties.This project aims to use computational techniques from computer vision and computer graphics to greatly enhance our understanding of speckle statistics, and significantly expand the scope of their applications.To this end, the project will explore algorithmic tools newly-developed by the PI that can accurately and efficiently simulate speckle patterns, to formulate better models of speckle formation.We will exploit our new understanding to develop new types of computational imaging systems that can directly measure speckle correlation, rather than the traditional pipeline where one captures speckle images and estimates their correlations algorithmically in post-processing.Finally, we will exploit these tools in multiple computational imaging applications, including: (i) Acquiring material parameters: estimating the type, size and density of particles composing a material of interest. (ii) Imaging fluorescent sources deep inside scattering tissue. (iii) Adaptive optics imaging.Potential impact is anticipated in numerous areas where speckle-based imaging techni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Commercialization of a first in class multiple sclerosis drug' (DIDO-MS) targeting Horizon 2020.

assistant: **Abstract**

Multiple sclerosis (MS) is a chronic and progressive neurodegenerative disease that is currently affecting 2.3 million people worldwide. Incidence rates of MS are significantly higher in Europe and in other regions located within the northern hemisphere. In Europe, the number of patients currently afflicted with MS is estimated to be at 700,000, with incidence rates ranging from 2.3-12.2/100,000 per year. GlobalData assessed the market value for MS treatments in 10 major markets (France, Germany, Italy, Spain, UK, US, Canada, Japan, China and India) in 2014 to be at €16.2 billion and predicts it to rise to approximately €18.82 billion by 2024. This increase is attributed to the projected sales of newly-approved drugs. The main shortcoming of current MS treatments ultimately lies in their lack of efficacy, specifically in that they are unable to prevent progressive neurodegeneration in MS patients. MS poses a significant economic burden on society as the disease affects primarily young people who are in their most economically-productive years. Aside from limited efficacies, current treatment options are also associated with severe side-effects (increased risks of infection, cancer), high costs and inconvenient administration routes (e.g. intravenous, intramuscular, subcutaneous). The aim of DIDO-MS is to assess the commercial viability of a newly identified small molecule as a drug in the treatment of MS.