RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Eagre/Aegir: high-seas wave-impact modelling'.

assistant: **Concept**

The overall objective is to create and deliver computational/mathematical modelling tools for solving problems in maritime engineering, based on advanced mathematical/numerical analysis and efficient implementation and testing in a general finite-element simulation environment offered by Firedrake (Imperial College with Leeds). Our key task is to offer training/research such that a so-called ""numerical wavetank"" is established by two ESRs for use in maritime-engineering wave basins, such as operational for consulting at the Maritime Research Institute Netherlands (MARIN Academy). Our research will provide the ESRs with a skill set that is highly attractive in the job market to employers engaged in high-end consulting. The integrated objectives are to create: (i) a numerical wavetank “ExtremeWaves” (ESR1) concerning modelling of extreme or rogue waves in wave basins integrated with (ii) a numerical wavetank “WaveTurbineImpact” (ERS2) concerning wave-structure interactions, especially wave-impact, on a dynamic wind-turbine mast. The overall objectives build on our recent and current collaborative work (between U. of Leeds and MARIN Academy) on the modelling of water waves and wave-structure interactions with (dis)continuous Galerkin finite-element methods. The above objectives offer challenging demands, not least because the prediction of wave motion around moving or flexible structures is a difficult computational task as a result of the requirement to track (generally using a sophisticated approximation) the a-priori-unknown nonlinear air-water and water-structure interfaces (and their cross-section, the waterline). Conquering these demands is timely because numerical simulations are cheaper than laboratory tests. Moreover, because in realistically motivated challenge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Develop methods to prioritise maintenance and rehabilitation needs of irrigation/drainage systems, on the basis of multi-parametric descriptorsof s cheme performance, asset condition and importante rating,which are all i' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The overall objective is to assist managers of irrigation systems to derive maximum benefits from investments made in system infrastructure through effective prioritisation of maintenance tasks.Specific objectives are to :* Evolve a set of condition descriptors of irrigation system components that describe their structural, functional, environmental and importance status effectively in a format that is acceptable and meaningful to the professionals in the field.* Identify an appropriate mathematical technique that is suitable for coping with the qualitative nature of the condition descriptors but capable of synthesising an overall performance criterion. Fuzzy sets theory will be investigated as a potential tool in this regard.* Evolve a methodology to incorporate component condition descriptors in the analytical framework for system performance estimation in order to help prioritise maintenance and rehabilitation needs.* Test the procedure in the field and assess relevance and acceptability.Expected OutcomeThe project aims to develop new and more rational procedures to relate potential maintenance needs to expected benefit. On the basis of these procedures maintenance tasks can be ranked using conventional benefit cost analysis and prioritised, thereby allowing Operation and Maintenance mangers to optimise the allocation of limited maintenance funds. It is not anticipated that the project will provide a final generalised procedure. However, it will set out a basis for more rational resource planning which can be refined and adapted through subsequent field trials.* Identify an appropriate measure or measures of hydraulic performance of the main conveyance and distribution system that can be related to measures of asset condition. This is likely to include the developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantitative picture of interactions between climate, hydrological cycle and stratospheric inputs in Antarctica over the last 100 years via the combined use of all water isotopes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Climate change and associated water cycle modifications have a strong impact on polar ice sheets through their influence on the global sea-level. The most promising tool for reconstructing temperature and water cycle evolution in Antarctica is to use water isotopic records in ice cores. Still, interpreting these records is nowadays limited by known biases linked to a too simple description of isotopic fractionations and cloud microphysics. Another key issue in this region is the stratosphere-troposphere flux influencing both the chemistry of ozone and decadal climate change. Data are lacking for constraining such flux even on the recent period (100 years). COMBINISO aims at making use of innovative methods combining measurements of the 5 major water isotopes (H217O, H218O, HTO, HDO, H2O) and global modelling to address the following key points: 1- Provide a strongly improved physical frame for interpretation of water isotopic records in polar regions; 2- Provide a quantitative picture of Antarctica temperature changes and links with the tropospheric water cycle prior to the instrumental period; 3- Quantify recent variability of the stratosphere water vapor input.The proposed method, based on strong experimental – modelling interaction, includes innovative tools such as (1) the intensive use of the recently developed triple isotopic composition of oxygen in water for constraining water isotopic fractionation, hydrological cycle organisation and potentially stratospheric water input, (2) the development of a laser spectroscopy instrument to accurately measure this parameter in water vapour, (3) modelling development including stratospheric tracers (e.g. HTO and 10Be) in addition to water isotopes in Atmospheric General Circulation Models equipped with a detailed descripti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Towards Uncovering the Splicing Code of the Gigantic Gene Titin in Familial Dilated Cardiomyopathy'.

assistant: **Innovation**

The sarcomeric protein titin (TTN) is mutated in 30% of patients with familial dilated cardiomyopathy (DCM), a common heart disease that is a global threat to the aging society. Aberrant alternative splicing of TTN is causally linked to DCM, therefore, to understand mechanisms of TTN splicing is crucial for developing therapeutic options, which so far do not exist for DCM. RBM20, a protein that regulates alternative splicing of TTN, is also mutated in many patients with an aggressive form of DCM. How RBM20 mediates alternative splicing of TTN is largely unknown. Due to its gigantic size, TTN mRNA is often precluded from transcriptome-wide single-cell analysis. Here, I aim to understand alternative splicing of TTN mediated by RBM20 on a single-cell level. To this end, I propose to develop a method for the detection of all transcript isoforms that can be produced by the 364 exons of TTN. Using this tool, termed TITIN-seq, together with complementary stem cell-based assays, I seek to analyze changes in the repertoire of TTN isoforms upon disease-relevant mutations in the RBM20 gene. Moreover, TITIN-seq is used to identify novel splice regulators of TTN, which, together with RBM20, could complete the picture of alternative splicing of TTN. The overarching goal is to construct a comprehensive map of TTN splicing by integrating data of all its isoforms in single cells and its regulatory proteins. I envision that knowledge of such a splice map can be exploited for developing therapeutic strategies to revert aberrant splicing of TTN in patients with DCM.


**Keywords:** dilated cardiomyopathy, titin, long-read sequencing, alternative splicing, single-cell transcriptomics, iPSCs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Internal Biofluid Dynamics in embryonic cardiovascular development, reduced order vascular growth models'.

assistant: **Concept**

The aim of this research is to develop cardiovascular (CV) fluid mechanics tools that can analyze and predict the vascular changes due to the growth and remodeling process (GR) during early embryonic cardiac development. Mechanical flow-induced loading, in addition to the genetic factors, is an essential regulator of the GR feedback process. Fluid-induced vascular network changes will be computed through transformative aims at the system level; that are coupled to the lower-level GR theories. The rich diversity of circulation systems found in nature inspired a novel reduced-order lumped parameter circulation model (LPM). For the first-time, LPM is integrated with multi-scale continuum mechanics vascular GR theories in order to establish a numerical feed-back loop between the GR response and instantaneous hemodynamic circuit parameters. A general network-based LPM model is proposed, again for the first time that covers the entire hydrodynamic network space where the numbers of vascular compartments, ventricles and their branching patterns evolve freely, but are subject to the cost functions founded on the biological optimality principles. Novel circuit similitude parameters that allow an unbiased energetic comparison will be developed. This framework will provide the global GR response of the entire circulation during development, energy/exergy budgets of complex congenital heart disease pathologies, and impact pediatric surgical treatments. At the organ level, The advanced boundary condition routines developed will transform the broader patient-specific CFD technology, which is currently used in clinical decision making. This project will have an impact on the pediatric and fetal cardiology, and CV surgery by giving researchers access to quantitative physiological infor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Catalytic oxidation as a tool sustainable fine-chemicals manufacture (SUSTOX)'.

assistant: **Concept**

The idea of the proposal is to solve problems of the chemical industries related to the application of conventional oxidation methods (using stoichiometric oxidants) in multi-step fine chemicals syntheses demanded by their customers on short notice. Time-to-market" constraints forbid the development of on-purpose catalytic oxidation methods despite their higher economical and environmental attractivity and force the industries into a strategy of waste-treatment or disposal instead of avoiding its generation. The project will focus on solving these problems by development of sustainable catalytic oxidation technologies : three oxidative transformation methods as such and in combination with membrane technology will be developed: oxidative halogenation, dark single oxygenation and epoxidation, and thereby increase European Industries' ability to produce fine chemicals in a competitive and environmentally friendly way."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced surgery probes for the radio-immuno guided detection of tumours' (APROT).

assistant: **Innovation**

The early detection of cancer and the optimisation of treatment is the best way to improve the length and the quality of life of several millions European patients every year. This project is aimed at developing a set of advanced probes that may greatly contribute to achieve this result. For example, the treatment of the lung cancer, that is the first cause of death for tumours in Europe, will benefit an accurate preparatory study of the Non Small Cell Lung Cancer (NSCLC) in order to adopt the most suitable therapy. This allows performing more specific, sighted, conservative but oncologically radical interventions. This result can be obtained by applying the radioimmuno guided surgery that consists in a detection of gamma rays by special probes able to identify several tumours and their potential nodal metastases. Similarly, the treatment of breast cancer - another dramatic pathology affecting European women - benefits the detection of the "sentinel node"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Flexible Production experts for reconfigurable assembly technology' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The goal of XPRESS is to establish a breakthrough for the factory of the future with a new flexible production concept based on the generic idea of 'specialised intelligent process units' ('expertons') integrated in cross-sectoral learning networks for a customised production.This knowledge-based concept integrates the complete process chain: production configuration (decrease of ramp-up time of at least 50%), multi-variant production line (varying types & volumes on a single line) and 100% quality monitoring.This concept is demonstrated in the automotive, aeronautics and electrical industry but can be transferred to nearly all production processes. XPRESS meets the challenge to integrate intelligence and flexibility at the 'highest' level of the product ion control system as well as at the 'lowest' level of the singular machine.The radical innovations of the 'expertonic networked factory' are knowledge and responsibility segregation and trans-sectoral process learning in specialist knowledge networks. The concept is built on co-ordinated teams of specialised autonomous objects (expertons), each knowing how to do a certain process optimally.They have the intelligence to choose the best-known production parameters for a given task. Assembly units composed of expertons can flexibly perform varying types of complex tasks, whereas today this is limited to a few pre-defined tasks.Communicating machines will be developed using self-organising and self-learning algorithms, data mining and common interfaces. By sharing the specific knowledge of each experton in a network, other expertons are able to learn from each other in one production line, but also between different lines as well as different production units.This architecture allows continuous process improvement. XPRESS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Psycho-semantics: new data for formal semantics models, stronger frameworks for experimental studies' in the context of a Seventh Framework call.

assistant: **Objectives**

Formal semantics provides rigorous, explicit models of linguistic meaning. Such models also include an account of the possible interactions between language and reasoning abilities. Over the last decade, thanks to the joint efforts of linguists and psychologists, experimental techniques have entered the field of formal semantics. With this methodological step forward, the field has become a full-fledged cognitive science, with a combination of highly predictive formal theories of the language faculty as a whole and sophisticated tools designed to test these theories. Our ambition is to take the field of psycho-semantics one step further in two directions.- Our first goal is to increase the theoretical sophistication of psycho-semantics. Initial experimental forays into semantics showed how to test divergent predictions between broadly different theoretical models. But in many cases, the formal semantic models in competition diverge on more fine-grained properties that have been overlooked in the experimental literature. These properties are now ripe for more focused investigation, requiring both theoretical sophistication and experimental meticulousness.- Our second goal is to widen the themes covered in psycho-semantics. Up till now, a disproportionate amount of research in psycho-semantics has focused on a very specific type of inference, so-called scalar implicatures. The present research program aims at studying a broad range of semantic phenomena, comprising entailments, implicatures and presuppositions; these are the traditional categories of inference, representing ways in which language and other abilities combine to produce meaning. We will extend the methods developed for a narrow set of phenomena to reveal new empirical facts (from naïve speaker’s judgments),
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'TeraHertz quasiOptical Receiver'.

assistant: **Innovation**

Remote sensing and monitoring in various environments solves many scientific and societal problems. Examples are: industrial air pollution control, global atmosphere surveillance, our planet system and the universe exploration, process controls in industry, and material research in laboratories. Molecular absorption/emission feature, combined with a high penetration depth of THz waves through dust, short wavelength allowing for high pointing directivity, all these factors determine the uniqueness of the THz range of electro-magnetic wave spectrum (0.1-10THz) in the mentioned applications. High radiometric sensitivity of THz wave detectors is a vital selection criterion for a THz system to become attractive. Uncooled THz detectors/mixers show adequate sensitivity only for frequencies below 1THz, whereas “supra-THz” (>1THz) detectors require cooling down to 4K. This limitation hinders exploitation of THz spectroscopy for such important application as atmosphere monitoring, local and global pollution surveillance, security, as well as universal sciences, in full. Small-scale satellites, balloons, portable sensors, can’t afford LHe cooling or power thirsty 4K cryo-coolers. For large-scale space missions, 4K cooling has already been utilized (e.g. Herschel and Planck Space observatories, COBE, etc), however it limited the missions lifetime significantly. In the frame of ERC StG grant Teramix, we developed technology, where high sensitivity and large bandwidth THz detection can be achieved at 20-40K temperature range, which can be accessed with compact and low power consumption coolers. The THOR project will lead the new technology through pre-commercial prototyping, a real-world application in an existing (representative) system, and explore marketing opportunities in both c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Long-term Biodiversity, Ecosystem and Awareness Research Network' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

This Network of Excellence (NoE) will create a European long-term inter-disciplinary research facility for research on the complex relationship between ecosystems, biodiversity and society. It will provide research support for policy assessment and development on the conservation and sustainable use of biodiversity in the European Union, and a stable facility for information retrieval and reporting on biodiversity-related issues. It will achieve this by implementing research, management and cultural changes within and between its component organisations, and through the development of integrated research agendas that will focus the research activities of its members on priority policy issues. The result will be a unique inter-disciplinary network linking a variety of stakeholders including research scientists, science communicators, policy makers and the public. In order to ensure durable integration of 24 partners from 17 countries, this NoE will build on 4 existing co-operative programmes that deal with complementary aspects of biodiversity research. These are PEER/CONNECTJLTER, ECSITE and ECNC. A novel approach to integration of ecological and socio-environmental methodologies will be developed, recognising the fact that biodiversity research should be done only in the context of ecosystems and their long- term dynamics. To achieve this, the core research undertaken by the NoE will be structured around a common framework based on the Drivers-Pressures-State-Impact-Response (DPSIR) model. This framework will ensure that research contributes directly to our understanding of the inter-relationship between biodiversity and the services it provides to society, and vice versa. The framework, and the research it supports, will also facilitate the long-term institutional cha