RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders' (INTEGROMED) under Horizon 2020.

assistant: **Objectives**

INTEGROMED is aiming to provide LBMC with the opportunity to integrate the experience of research excellence institutions and existing resources by creating a research and innovation network with three internationally leading organizations in the translational medicine area – University of Dundee, Lund University, and Weizmann Institute of Science. The strategy of INTEGROMED is to increase excellence and develop sustainable approach targeting virtually all aspects of translational medicine including the optimal use of clinical and biobank resources, integration of different omics in systemic workflow, reaching development of bedside applications and fostering entrepreneurism. Project has a strong focus on study of metabolic disorders including type 2 diabetes, however the training, mentoring and stuff exchange activities as well as practical outcomes will be available for other fields including researchers, clinicians and other stakeholders in Latvia, promoting the implementation of the developed strategies at larger scale. The result of project will be accomplished by following three main objectives. (1) To improve and optimize the use of resources provided by large biobanks and prospective cohorts in combination with national health care system, improve knowledge in establishment of clinical studies for development of precision medicine approaches. (2) To strengthen collaboration-based training of specialists in areas of multi-omics approaches, bioinformatics, and modelling to increase excellence in implementing cutting edge multi omics technologies in such areas as genomics, methylation and expression profile, microbiome and metabolome analysis. (3) To elaborate a long-term strategy and sustainability plan involving all relevant stakeholders, ensure development and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Grid services based environment to enable innovative research'.

assistant: **Objectives**

The Chemomentum project will provide Grid-based solutions for workflow-centric, complex applications, such as risk assessment, toxicity prediction and drug design. It will focus on tools for dealing with data and knowledge in an efficient and reliable manner. The Chemomentum software will enable users to assess the knowledge stored in the system in terms of applicability, range of validity and reliability, and will make it easy to use this knowledge for predictive and decision-making purposes.Leveraging developments in enterprise software systems, such as service oriented architectures and business integration, Chemomentum will achieve these aims by taking up and enhancing European Grid middleware. Grid-enabling relevant applications and building services on the Grid, Chemomentum will provide an easy-to-use Grid system that focuses on the end users, allowing them to use powerful tools in an efficient and transparent way. Intuitive, task-oriented user interfaces will allow the users to focus on their work, keeping any Grid related complexity hidden. Administration of the Grid, for example management of users, management of software licenses and application deployment on the Grid will be greatly simplified.The generic system including many applications will be tested in the context of evaluation and risk assessment of chemicals: substances have to be carefully tested and assessed for possible risks to human health and the environment prior to marketing and distribution. This requires massive efforts in terms of time, money and testing animals. The Chemomentum system has the potential to boost time-effectiveness and reduce the need for animal testing in this area by providing powerful solutions for the computational, in silico", testing of chemicals. This concretely suppor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional analysis of RasGRP1 SNPs in autoimmune disease' (2007-2013).

assistant: **Concept**

Autoimmunity is caused by chronic inflammation mediated by T- and B-lymphocytes. Thus far, treatment of autoimmunity consists of general immune suppressants, causing unwarranted side effects, without curing disease. Therefore, the need for a specific treatment targeting the cause of disease is growing. In this fellowship will focus on elucidating how SNPs (single nucleotide polymorphisms) in RasGRP1 play a role in aberrant lymphocyte activity in patients with autoimmunity. RasGRP1 is critical in the activation of Ras, resulting in lymphocyte activation. Preliminary data show that a point mutation in Rasgrp1, Rasgrp1Anaef, results in autoimmunity in mice, characterized by anti-nuclear antibodies and activated CD4+ T cells. Moreover, Rasgrp1Anaef/wildtype heterozygote mice show a similar phenotype, arguing that one wildtype allele cannot compensate for the Rasgrp1Anaef allele. We have established that hypomorphic Rasgrp1 variants can exert a dominant negative effect, which relies on coiled-coil mediated dimerization with wildtype Rasgrp1. This new concept of RasGRP1 dimerization, suggests that monoallelic, non-synonymous RasGRP1 variants may affect the activity of a RasGRP1 dimer in patients.In the proposed fellowship, I will: (1) Model non-synonymous SNPs in patients to our structure of RasGRP1 and test the functional effect, (2) Establish how dimerization affects RasGRP1 function, and (3) Establish if RasGRP1 signaling is aberrant in lymphocytes of patients.This will help us understand how autoimmunity comes about, and will provide new potential strategies for development of more specific therapies. I anticipate that these RasGRP1-centric studies will function as a paradigm for future studies on dysregulated signaling pathways in autoimmune T cells. This fellowship will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart dismantling, sorting and REcycling of glass Fibre REinforced composite from wind power Sector through Holistic approach' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

REFRESH aims to develop and demonstrate a novel circular, smart system for an improved recycling (>90%) of glass fiber-reinforced composites derived from wind turbine dismantling or reblading, with high purity level. The project will focus on the mechanical and thermal treatment of waste, but it will strongly involve the entire reverse circular value chain: from end-of-life blades to a wide range of re-manufactured products.  REFRESH proposes a flexible re-manufacturing line: when a wind-blade is decommissioned, it will be performed a selection of optimal recycling process according to the technical condition of the blade and current market demand; this will be achieved by using a dedicated tracking tool for collecting, protecting and sharing information and an embedded decision-making tool software for selecting time by time the most sustainable approach to recycling.  The project will focus on the most robust and mature mechanical treatments, where composites are grinded in various size and used as new raw material to create multifunctional panels for automotive, marine applications, home furniture, civil construction. The project will design and deploy an up-scaled process, starting from the already available remanufacturing line of GEES Recycling (Aviano, Italy). Another robust and proven process is the thermal technology, here proposed by Gjenkraft, that allow also to recover long and “clean” fibers, without matrix, having properties comparable with the one of virgin fibers. The holistic approach developed within the project will be validated by means of LCA/LCC/health-safety analysis. The project will finally contribute to the increase of awareness among stakeholder communities through direct engagement, aimed at replicating the solution in Europe and guarantee a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'NURSING INFORMATICS : GENERIC HIGH-LEVEL TRAINING IN INFORMATICS FOR NURSES; GENERAL APPLICATIONS FOR LEARNING AND EDUCATION'.

assistant: **Concept**

NIGHTINGALE seeks to boost telematics training for nursing in Europe, through the use of information systems and coordination with other health sector training initiatives. A professional nursing users' group will monitor and publicise project activity at workshops and conferences. Courseware material will include multimedia technologies and appropriate software packages, alongside books and other traditional teaching material. Collaboration of multimedia publishers will be sought in marketing the courses.NIGHTINGALE is an essential project in the planning and implementation of strategy in Training the Nursing Profession in using and applying healthcare information systems. NIGHTINGALE will contribute towards the appropriate use of the developed Telematics infrastructure across Europe by educating and training in a harmonising way nurses across Europe in the upcoming field of Nursing Informatics.NIGHTINGALE will cooperate with all European actions and projects in the area of training health care professionals to provide consensus curriculum development in Nursing Informatics. The most essential part and contribution of this development will be provided by the Users' Group which will comprise of nursing professionals, nursing systems professionals and health policy makers in the area of nursing education represented from all European Union members states. The Users' Group will be the monitoring and dissemination body of the work performed, where workshops and conferences will be the major platform of the consensus process. NIGHTINGALE will develop courseware material based on the curriculum development process using multimedia technologies. Computer based training software packages in Nursing Informatics will be the basis of the training material and the corresponding co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regulation of immune responses by CD2, CD244 and related receptors' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In order to understand how the mammalian immune system provides protection against pathogens, it is important to understand the molecular basis of immune system function. CD244 is one of the receptors related to CD150 (SLAM) with the potential to bind the adaptors, SAP and EAT-2. It has recently been shown by the host laboratory that the outcome of engagement of these receptors depends on the context of the interactions, such as which other receptors are engaged, the level of activation, and between which cells. The overall goal of this project will be to establish a paradigm for the function of the family of CD150-related receptors. With an initial analysis of CD2 and CD244, and later inclusion of additional family members, a thorough understanding of how this family of receptors modulates leukocyte function will be developed. Our specific aims are as follows. First, we plan to explore the parameters which determine the overall effect of CD244 and CD2 engagement during an immune response. Using a human NK cell line expressing CD2 and CD244, and a mouse T-cell hybridoma, we will examine the effects of the engagement of these receptors and recruitment of SAP and EAT-2 on cytotoxicity and IFN-gamma production. Second we will perform in vivo experiments relating human data on CD244 function to a mouse tumour model, in which the in vivo activity of a CD244 blocking antibody will be used to analyze the effect of CD244 blockade in resistance to tumour growth. Finally, using surface plasmon resonance and recombinant proteins, we will establish a hierarchy of likely interactions of intracellular signalling molecules with additional members of the CD150 receptor family. Using the model system established in the first two aims, the predictions derived from the BIAcore experiments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'String Phenomenology in the LHC Era' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

String Theory is the leading candidate for a theory of quantum gravity including Particle Physics. In the last ten years important progress has been made in the construction of string theory solutions resembling the Standard Model (SM) of Particle Physics. String compac- tifications giving rise to the gauge group of the SM and three generations of quarks and leptons have been constructed. It has also recently been found that quantized fluxes of the anti-symmetric fields present in the theory  provide for a solution for the long standing problem of moduli stabilization in String Theory.  On the other hand a new era for Particle Physics  has  begun  with the starting into operation of the LHC accelerator in 2010. The new data is expected to reveal the origin of the masses of all particles and what is the physics underlying it. New forces or symmetries like supersymmetry, extra dimensions etc. could be found. Whatever is found it will provide stringent tests of models for physics beyond the SM and also string theory compactifications. The purpose of this project is to make progress in the construction of string semi-realistic solutions and try to obtain information from the LHC data in order to constraint the underlying theory. In order to do that a general study of different classes of string compactifications will be made. If e.g. supersymmetry is found at LHC, we will be able to compare the structure of soft SUSY-breaking soft terms in large classes of string models with experimental data, giving important information about the underlying string theory.  One of the  objectives of the project  is to answer the question: What is LHC telling us about string Theory?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Raising citizens and shakeholders awareness, acceptance and use of new regional and urban sustainibilty approaches in Europe' under Sixth Framework.

assistant: **Concept**

RAISE is a Specific Support Action included in the FP6 Sub-priority 1.1.6.3 Global Change and Ecosystems, whose objectives were set out in the Work-Programme as follows: i) consolidation and impact assessment of results achieved in EU research projects relating to regional and urban sustainability aspects; ii) exploitation of these results in the context of a citizens conference" aiming to test the acceptability of new sustainability approaches and technologies by the user community. These objectives will be achieved by RAISE by arranging a citizens' conference process centred on a bundle of new sustainability approaches and technologies which have been identified by projects selected among those funded within the 5th Framework KA City of Tomorrow and Cultural Heritage or pertaining to the cross-cutting issues of sustainable development: estimating thresholds of sustainability and externalities, tools integrated sustainability assessment. The projects will be selected from a list of projects provided by the Commission. RAISE will concentrate on the areas of city planning and management, built environment and urban transport. The RAISE citizens conference will involve 25 randomly selected citizens from the 25 EU member states. They shall represent the "average citizens" from the different countries of Europe. They will be asked to formulate their view on the acceptance and use of selected urban sustainability approaches, technologies and solutions coming from EU research findings in a sequence of three preparatory meetings, whose final results will be reported to a final Conference event in Brussels, involving also stakeholder representatives and politicians. The citizens conference will be supported by a RAISE participatory assessment framework prepared by the experts,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'BIOfilm-REsistant Materials for hard tissue Implant Applications' (BIOREMIA) under Horizon 2020.

assistant: **Objectives**

Implant-associated infections, commonly caused by biofilm-forming bacteria, are highly problematic for the patient, the healthcare system, and society. BIOREMIA will recruit 15 doctoral students (ESRs) and provide a highly inter-disciplinary joint research & training programme focused on the key issues that determine the future antibacterial biomaterials and technologies for orthopaedic and dental applications. BIOREMIA links 7 academic and 4 non-academic beneficiaries as well as 6 partners from 11 European countries (Germany, Austria, Greece, Sweden, UK, Spain, Italy, France, Switzerland, Ireland and the Netherlands) and the USA. The ESRs will be supervised and trained by world-class academic and industrial organisations, combining technical knowledge with hands-on training in state-of-the-art research projects. BIOREMIA training program will include face-to-face and online scientific courses in biomaterials & surface engineering, biotechnology,nanotechnology, implant manufacturing, biochemistry, microbiology and biofilm. This will be complemented by education in transferable skills such as entrepreneurship, management, IPR, communication etc. useful for getting an innovation-oriented mind-set of young researchers. Participating in BIOREMIA will make PhD students highly attractive for employers and open up doors for their successful careers in research, regulation, consulting, industry and the healthcare system. They will be experts for the better assessment of the antibacterial functionality of materials and surfaces and for delivering successful strategies for the medical device industry and the healthcare system. The strong involvement of the industrial sector will provide the ESRs with a holistic perspective on career opportunities. Beyond the trained researchers,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AN Integration of Mitigation and Adaptation options for sustainable Livestock production under climate CHANGE' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

ANIMALCHANGE will provide scientific guidance on the integration of adaptation and mitigation objectives and design sustainable development pathways for livestock production in Europe, in Northern and Sub-Saharan Africa and Latin America. ANIMALCHANGE will inform public policy development in EU27 and propose cooperation programs addressing smallholder livestock farming in selected developing countries. The core analytical spine of the project is a series of coupled biophysical and socio-economic models combined with experimentation. This allows exploring future scenarios for the livestock sector under baseline and atmospheric CO2 stabilization scenarios. These scenarios are first constructed in Component (CP) 1. They are elaborated and enriched by breakthrough mitigation and adaptation options from CP 2 at field and animal scales, integrated and evaluated at farm scale in CP 3 and used to assess policy options and their socio-economic consequences in CP 4.ANIMALCHANGE will:- Quantify and reduce uncertainties in greenhouse gas (GHG) emissions and assess climate change impacts on livestock systems (including grasslands)- Revise estimates of the GHG balance of livestock systems and integrate soil carbon sequestration- Integrate climate variability and extremes into the assessment of impacts, adaptation and vulnerability of livestock systems to climate change- Develop breakthrough technologies for adaptation and mitigation to climate change for both ruminants and monogastrics- Study and quantify trade-offs and synergies between adaptation and mitigation options- Assess the potential societal and sectoral costs and benefits of these options for the livestock sector in Europe and in study regions of Africa and Latin America- Assess climate change vulnerability of animal produ