RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'IRC Norway' to be submitted under Sixth Framework.

assistant: **Abstract**

Proposal abstract : IRC Norway will tailor its services to meet the needs of its local clientele, while respecting the IRC objectives. As stated in the Research and Innovation Work Programme, the main tasks of the IRCs will be to: - Promote the transnatio nal transfer of technologies and knowledge, whatever their origin, in accordance with the needs of the local industrial, economic and social fabric - Stimulate the capacity of firms to adopt new technologies by establishing their needs and ability for t ransnational co-operation and partnerships - Promote the transnational dissemination and exploitation of the results of Community research, notably those results identified as suitable for third party exploitation and including co-operation with EURE KA and ESA (European Space Agency) - Provide other key services which help promote or facilitate innovation and transnational technology transfer - Pursue possible synergies between the IRCs and the Innovating Regions in Europe (IRE) network - Develop n ew methods, e.g. for the promotion of transnational clusters and/or measures to facilitate the development of the European Research Area. Operational objectives : IRC Norway will address the following operational objectives : 1. Promotion of inward Tra nsnational Technology Transfer and RTD exploitation and dissemination services 2. Promotion of outward Transnational Technology Transfer and RTD exploitation and dissemination services 3. Stimulate the capacity of SMEs to adopt new technologies 4. Signpos ting and co-ordination 5. New methods of promoting Transnational Technology Transfer 6. Joint Events with the Norwegian and European Association of CNC Machine Tool Users 7. Repurchasing arrangements between Norway and Spain 8. Delivering high quality TO a nd TR to the IRC Ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'What Epistemology for Sustainability Science? Experiments and Theories for Social Transformation'.

assistant: **Concept**

Sustainability science is an innovative research field dealing with complex socio-ecological problems of our time, from climate change and rapid urbanization to pandemics and loss of biodiversity. A major goal for sustainability science is to support societal transformations towards sustainability by generating, testing, and integrating (1) system knowledge about sustainability problems, (2) target knowledge about desirable futures, and (3) transformational knowledge about effective interventions that can lead from the problems detected to the desirable futures. Thus far, epistemological work has focused primarily on the foundations of system and target knowledge and has neglected transformational knowledge. Therefore, a major task for an epistemology of sustainability science is now to understand how transformational knowledge is generated and tested. Because of the central role they play in transformational sustainability science, in EPISUS, I take transformational experiments as entrance point to develop an epistemology of transformational sustainability science. I ask: What kind of sustainability science do we need to generate and test transformational knowledge and what role can transformational experiments play in this science? In EPISUS, I address this question by focusing on: 1. the main characteristics of transformational experiments, 2. the criteria used to evaluate experimental results and 3. the kind of theories that support, or could support, the production of transformational knowledge. I use a research design that combines the investigation of concrete examples of transformational experiments and conceptual reflections using analytical tools from the philosophy of science. EPISUS will provide a new conceptualization of transformational experiments as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Establishment of Quality Assurances for the Detection of Biological Toxins of Potential Bioterrorism Risk' (EQUATOX).

assistant: **Concept**

The features of biological toxins like ricin, botulinum toxins, staphylococcal enterotoxins and saxitoxin place them at the interface of classical biological and chemical agents. They could be used for terrorist attacks on the basis of their availability, ease of preparation, the high toxicity and/or the lack of medical countermeasures. Some of the toxins are considered among the most relevant agents in the field of bioterrorism, for which the current preparedness within European countries should be further improved to limit casualties in the case of an intentional release.While different technologies for toxin detection and analysis have been established, hardly any universally agreed “gold standards” are available. Generally, proficiency tests and certified reference materials for the mentioned toxins are lacking. In this context, the recent results of the first international proficiency test on the detection of one of the toxins provided highly relevant insights and a basis for further development.EQuATox will address these issues by creating a network of expert laboratories among EU 27 and associated countries, focussing on the detection of biological toxins and integrating experts from the security, verification, health and food sector.Four large EU-wide proficiency tests on the mentioned toxins will be organised with 27 laboratories from 20 countries worldwide so far being interested in participating and joining the network. The task will include the generation and characterisation of toxin reference materials which in the future can be further developed into ISO-compliant certified reference materials.Based on the status quo of toxin detection described in EQuATox, good practices and critical gaps in detection technology will be identified as foundation to harmon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Targeted Microarrays for 5-hydroxymethylcytosine-based Diagnosis of Hematological Malignancies'.

assistant: **Concept**

5-hydroxymethylcytosine (5hmC) is an oxidized form of 5-methylcytosine (5mC). It is the first step of reversing DNA methylation and an important indicator of dynamic epigenetic changes in genomic DNA. One characteristic of cancerous transformations is dramatic modulation of the epigenomic landscape. Consequently, changes in the distribution of 5hmC have been shown to correlate with a broad range of cancers and is potentially a powerful disease biomarker. Nevertheless, existing methods for mapping 5hmC are complex and expensive thus hindering the translation of 5hmC research into clinical use. This project aims at developing a custom DNA chip for 5hmC that will allow cost-effective and targeted analysis of disease biomarkers. We will use our patented procedure for direct fluorescent labeling of 5hmC in combination with commercially available genome-wide microarrays to create maps of 5hmC distribution in health and disease. These large-scale arrays will be used in the discovery phase to identify cancer biomarkers. In the second phase, only the subset of genomic loci that contain medically significant modulation in 5hmC will be used to design and print a custom microarray containing only the relevant probes. This concept predicts a cost reduction of 10-100 fold which will remove the barriers for large scale research and high volume testing. Disease specific diagnostic chips are attractive products with direct impact on society and economy via promoting more accessible testing and patient management. Our preliminary results indicate that we will be able to offer a universal platform for even the most challenging samples including cell-free DNA analysis from liquid biopsies. We envision it as an enabling technology for 5hmC research, biomarker discovery and companion diagnos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Development of an Innovative Tilted Counter-Rotating Vertical Axis Wind Turbine (TCR-VAWT) Optimized to Operate Tilted on Spar-Buoy Floating Platforms'.

assistant: **Concept**

Offshore wind power is set to be a key driver in the global shift towards renewable energy. The EU Green Deal aims to boost offshore wind capacity by 300 GW by 2050. However, 80% of the world's offshore wind potential is located in deep waters where traditional fixed-bottom turbines are impractical. This underscores the urgent need for innovative and cost-effective floating wind turbine technologies. This MSCA PF addresses this need by developing a novel Tilted Counter-Rotating Vertical Axis Wind Turbine (TCR-VAWT) specifically optimized for spar-buoy floating platforms in deep-water environments, leading to an estimated 40% increase in turbine's performance.Tilting the TCR-VAWT will enhance power output by capturing wind from both upwind and downwind regions, while the counter-rotation will enable the use of direct-drive generators. This technology has a huge potential to significantly reduce the Levelized Cost of Energy (LCOE), by approximately 30% due to the elimination of complex gearbox systems and improved aerodynamic performance. The research methodology will combine high-fidelity Computational Fluid Dynamics (CFD) for detailed aerodynamic analysis with the Finite Element Method (FEM) for structural feasibility. Prototyping and wind tunnel experiments will be conducted to validate the numerical simulations. Finally, the validated data collected will support developing and refining a Machine Learning algorithm, the Tilted VAWT Design and Optimization Code (TVDAOC), aimed to reduce the time needed for design optimization by 30-40%. The project includes two secondments: a three-month stint at World Wide Wind, the sole company specializing in TCR-VAWT technology for structural studies, and five months at the University of Bergamo to conduct experiments.


**Keywords:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Characterizing the effects of the Mediterannean diet on endothelial dysfunction' in the context of a Seventh Framework call.

assistant: **Objectives**

It is well established that death rates from cardiovascular disease are substantially lower in Mediterranean countries, which has been attributed the consumption of an unique collection of foods referred to as the Mediterranean diet. Although the mechanisms underlying the effects of the Mediterranean diet on cardiovascular disease remain largely unclear, a important role for polyphenols and monounsaturated fatty acids, which are abundantly present in olive oil, is suspected. Endothelial dysfunction is a hallmark for the initial stage of vascular dysfunction and has been associated with cardiovascular disease. Consumption of high fat meals result in an impaired postprandial endothelial function as measured by flow-mediated dilatation, markers of inflammation and markers of oxidative stress. However, the mechanism that mediate the effects of high fat meals on endothelial function remains unclear. The aim of the present project is to uncover the mechanisms that underlie the preventive effects of the Mediterranean diet on development of cardiovascular diseases, with a focus on endothelial dysfunction and the specific impact of monounsaturated fatty acids and polyphenols. To that end, we will perform whole genome expression profiling on Peripheral Blood Mononuclear Cells collected from 20 healthy young Caucasian men that received a milkshake containing 55 grams of SFA enriched or MUFA enriched fat as part of a single-blind cross-over dietary intervention trial. In addition, we will expose freshly isolated HUVEC and PBMC with specific dietary fatty acids and polyphenols for analysis of gene expression and protein secretion of specific markers of endothelial activation, inflammation, and oxidative stress. Characterizing the activity and mechanism of action of these dietary com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Holocene climate reconstructions from western Anatolia based on speleothem data'.

assistant: **Innovation**

Speleothems (calcareous cave deposits) are among the most useful archives that are utilized to reconstruct pastenvironmental conditions, including palaeotemperature and moisture conditions, on decadal to millennial timescales. Highquality(high-resolution, precisely dated, complete, and robust) regional speleothem-based palaeoclimate records,specifically revealing the past variability of rainfall regimes, is of great importance for human water, and hence for the futureestimations pertaining the human-climate-environment relationship. Research suggests that decreases in rainfall-drivenwater availability during the late Holocene in the Eastern Mediterranean region was one of the main reasons for the declineand/or collapse of some former civilizations (e.g., decline of Ottoman Empire in the preindustrial era, collapse of Uruk societyin Mesopotamia during the transition from chalcolithic to the early Bronze Age, societal collapse of the Late Bronze Age).This project will generate an extensive dataset through a multi-proxy approach of isotope and trace element geochemistryusing Holocene-aged stalagmites from several cave sites located in western and southwestern Anatolia (Turkey). The mainobjectives of the proposed action are: (1) to produce precisely-dated (U-series dating) and high temporal resolution paleorecordsconcerning the Holocene climate dynamics that affected the living patterns of ancient Aegean civilizations (e.g.,Classical Greek and Roman), (2) to trace possible impacts of human-induced environmental and atmospheric pollutionthrough a suite of high resolution stalagmite records, including stable isotope and trace element variations (e.g., changes incarbon and sulphur isotope ratios), and (3) to explore whether the speleothems reflect Holocene volcanic activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of a low cost, high resolution 270° 3D solution for full face capture to provide low cost customised eyewear' (FITSYOU).

assistant: **Innovation**

The general rise of eyewear prescriptions and the subsequent need for perfect fitting eyeglasses is partly driven by the growing ageing population, increasing effect of conditions such as myopia and hyperopia, extensive use of computers and need for protection against the sun’s ultra-violet radiation. Current eyewear prescription methods are unable to accurately account for variations in facial features e.g. size of nose, distance between eyes. Present procedures require a consumer to try out several frames before finally choosing a close fitting frame that is not necessarily a perfect fit. Poor fitting glasses can cause discomfort and misalignment of the lenses with the eyes, a problem which has resulted in dissatisfied customers returning glasses, costing an estimated €500 million/year in losses in Europe. Our solution will use 3D scanning technologies to scan a consumers’s face, identify key facial landmarks and provide accurate measurements.  This will then be used to determine either the best fitting glasses or a specification for custom fit glasses that can be manufactured using 3D printing technologies.  The solution will be targeted at large eyewear retailers and manufacturers where there is an opportunity to implement the solution across a large network of stores.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'analyse Soluble + Membrane complexes with Improved LILBID Experiments' (2007-2013).

assistant: **Innovation**

Crucial processes within cells depend on specific non-covalent interactions which mediate the assembly of proteins and other biomolecules. Deriving structural information to understand the function of these complex systems is the primary goal of Structural Biology.In this application, the recently developed LILBID method (Laser Induced Liquid Bead Ion Desorption) will be optimized for investigation of macromolecular complexes with a mass accuracy two orders of magnitude better than in 1st generation spectrometers.Controlled disassembly of the multiprotein complexes in the mass spectrometric analysis while keeping the 3D structure intact, will allow for the determination of complex stoichiometry and connectivity of the constituting proteins. Methods for such controlled disassembly will be developed in two separate units of the proposed LILBID spectrometer, in a collision chamber and in a laser dissociation chamber, enabling gas phase dissociation of protein complexes and removal of excess water/buffer molecules. As a third unit, a chamber allowing determination of ion mobility (IM) will be integrated to determine collisional cross sections (CCS). From CCS, unique information regarding the spatial arrangement of proteins in complexes or subcomplexes will then be obtainable from LILBID.The proposed design of the new spectrometer will offer fundamentally new possibilities for the investigation of non-covalent RNA, soluble and membrane protein complexes, as well as broadening the applicability of non-covalent MS towards supercomplexes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NANOtechnology INDustry EXchanges' to be submitted under Fifth Framework.

assistant: **Abstract**

This project is set to establish a solid link between the Micro-technologists of NEXUS and the European community of Nanotechnology researchers and scientists of PHANTOMS. This will be achieved through nanoINDEX. Collaborations with other European networks and European initiative will be set-up during the lifetime of this project. The project will identify the key experts and groups working in nanotechnology and bring a selected number together as a team. Meetings will be organised between nominated experts from this team and NEXUS through the User Supplier Clubs, the Roadmap and Market Analysis Task Forces and the general Membership. A series of workshops will also be organised at which the state-of-the-art will be described. The reports resulting from these meetings will be made publicly available through the NEXUS website and e-zine, the PHANTOMS newsletter and MST News.Objectives:To identify the key experts and groups in nanotechnology and update this every three months. To select a team of experts to disseminate the most up to date information to the NEXUS and PHANTOMS membership and feedback the needs of microtechnology users to nanotechnology providers. To report on the resulting situation to the NEXUS and PHANTOMS membership through a series of workshops, and to wider public through the NEXUS website and e-zine, the PHANTOMS newsletter and MST News.Work description:1 Define and describe the objectives of nanoINDEX to the NEXUS and PHANTOMS memberships;2 Identify the basic requirements for the individuals and national and international groups likely to join nanoINDEX;3 Identify experts and group candidates, invite key experts and organisations to work with nanoINDEX, and form the nanoINDEX Team;4 Write a project plan and delegate specific responsibilities and tas