RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantitative risk assessment strategies for novel foods' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The overall objective of this project is to develop and validate the scientific methodology which is necessary for quantitative risk assessment of second generation" of novel foods to be marketed in EU in accordance with the EU Regulation 258/97 of 27 January 1997 concerning novel foods and novel food ingredients. The project is designed to address both the risk assessment (including hazard identification, hazard characterization, exposure assessment and risk characterization) and the risk/benefit equation. The specific objectives are to: - Develop and validate the new methodologies for assessing the safety, the nutritional properties and the efficacy for health promotion of 3 different types of "second generation" novel foods, exemplarily a genetically modified potato with altered levels of inherent toxicants (glycoalkaloids), a conventionally bred rice with genetically lowered level of an anti-nutrient (phytic acid) and 2 functional food ingredients of natural origin (phytosterol esters). - Exploit the use of genomic and profiling techniques for characterisation of the novel foods as well as for the development of sensitive and specific biomarkers in the in-vivo and in-vitro studies, as the basis for the hazard characterization. - Exploit a recipe database and software code built upon specially designed conceptual models and algorithms for probabilistic modelling of population exposure to the 3 types of novel foods - Establish a quantitative risk/benefit equation based on probabilistic modelling of the biological data and the exposure data addressing the problems / advantages as perceived by the public. - Communicate the findings of the project to consumers and other stakeholders based upon an indicative consumer survey."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'European assessment of the Transport impacts on climate change and Ozone depletion'.

assistant: **Innovation**

The ATTICA consortium offers to provide the European community with a coherent series of assessments of the impact of transport emissions on climate change and ozone depletion. Three assessments will cover the emissions of single transport sectors, viz. of aviation, shipping, and road and rail traffic. Another assessment deals with metrics that allow describing, quantifying, and comparing in a fair way the effects of the transport emissions in the atmosphere. Finally, a synthesis of the foregoing assessments will be written that will provide the overview of the impacts of the emissions of all transport sectors on climate change and the ozone layer.For the first time, different modes of transport will be consistently assessed. The consistent assessment allows the interested citizen to estimate in principle their own contribution to environmental problems and to compare it to that of others. Apart from policy and decision makers, the synthesis assessment will help journalists, teachers, and others, to digest the results and to present them in public media, in schools and universities, ensuring wide spread of the results. The assessments and the synthesis report will inform the EU in developing its policy and will strengthen its position in international climate conventions and other international agreements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding and measuring SUb-23 nm particle emissions from direct injection engines including REAL driving conditions' (SUREAL-23).

assistant: **Concept**

A large proportion of the total number of particles emitted from direct injection engines are below 23 nm and although the EU aims to regulate those emissions and impose limits for new light duty vehicles, this is not yet possible due to the absence of accurate quantification methods, especially under real driving conditions. The main reason for this is the absence of adequate knowledge regarding the nature of sub-23 nm particles from different engine/fuel combinations under different operating conditions. SUREAL-23 aims to overcome such barriers by introducing novel measurement technology for concentration/size/composition measurements. The recently established supercontinuum laser technology will be coupled to photoacoustic analysis and will also be employed for photoelectric ionization aerosol charging to achieve real-time, composition size-specific analysis of the particles. In parallel, state of the art aerosol measurement techniques will be advanced for better compatibility with sub-23 nm exhaust particles as well as on-board use. The developed instrumentation will assess sub-23 nm particle emissions from both Diesel and GDI vehicles accounting for effects of the fuel, lubricants, aftertreatment and driving conditions for existing and near-future vehicle configurations. The most suitable concepts will be developed for PN-PEMS applications and evaluated accordingly. The project will provide measurement technologies that will complement and extend established particle measurement protocols, sustaining the extensive investments that have already been made by industry and regulation authorities. The project will deliver systematic characterization of sub 23-nm particles to facilitate future particle emission regulations as well as to assess any potential trade-off bet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health' (EUCAN-Connect), addressing dissemination and exploitation.

assistant: **Impact**

Rapid progress in information and biotechnologies offers the promise of better, personalized health strategies using rich phenotypic, environmental and molecular (omics) profiles of every individual. To capitalize on this great promise, key challenge is to relate these profiles to health and disease while accounting for high diversity in individuals, populations and environments. Both Europe and Canada have long-term investments in population-based prospective cohort studies providing essential longitudinal data. These data must be analysed in unison to reach statistical power, however, presently cohort data repositories are scattered, hard to search and integrate, and data protection and governance rules discourage central pooling.EUCAN-Connect will enable large-scale integrated cohort data analysis for personalized and preventive healthcare across EU and Canada. This will be based on an open, scalable data platform for cohorts, researchers and networks, incorporating FAIR principles (Findable, Accessible, Interoperable, Reusable) for optimal reuse of existing data, and building on maturing federated technologies, with sensitive data kept locally and only results being shared and integrated, in line with key ELSI and governance guidelines. Widespread uptake will be promoted via beyond state-of-the-art research in close collaboration with leading cohort networks, focused on early-life origins of cardio-metabolic, developmental, musculoskeletal and respiratory health and disease impacting human life course.To address challenges of sustainability and curation, we will deliver innovative solutions for distributed, low-cost data harvesting and preservation, community curation/harmonization, privacy protection, open source bioinformatics toolbox development, and internationa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Electrodeposition of compositionally modulated multilayers for integrated magnetoresistance magnetic field microsensor arrays'.

assistant: **Objectives**

Research objectives and content In order to increase the magnetoresistive (MR) characteristics in planar multilayer structures, current-at-an-angle-to-plane (C. iP) geometry's have been proposed. One of the main objectives of this proposed research is to combine the growth techniqu of electrodeposition with various lithographic methods in order to fabricate novel CAP structures which will take the forrr of multilayered hemispheres connected together at their bases. The advantages of using both electrodeposition and a nat ral lithography technique being low capital investment, simplicity, low deposition temperatures and increased flexibility. 'he growth and lithographic techniques will be optimised in order to give uniform growth across the substrate, uniform I beer thicknesses and an optimised magnetoresistance response. Investigations on patterning the substrates so that contacts can be . made to the structures for magnetoresistance measurements will be carried out. l The ultimate aim of the project will be, using the skills and techniques learnt, to design and fabricate a demonstrator microse sor l array device.  l Training content (objective, benefit and expected impact) The interdisciplinary and complimentary training aspects that both MTM and IMEC have to offer will lead to a broaden ng l experience which will allow me to make a significant contribution to the growing field of integrated magnetoresistive magn . field sensor technology Links with industry / industrial relevance (22) There is great interest from industry in the incorporation of magnetic materials in the fabrication of multichannel microsens using the well established semiconductor technology. Many groups in Europe (for example, Thomson and Philips) are work towards the goal of using this technology f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dynamics of Deep Earthquakes' (SODA), addressing dissemination and exploitation.

assistant: **Impact**

Deep earthquakes (>70km) are a puzzling yet insufficiently understood process occurring inside the Earth. Despite their potential for significant magnitudes (up to 9) and associated hazards, their physics remains elusive. The theoretical inhibition of earthquakes with increasing temperature and pressure at depth contrasts with over a century of observed occurrences, prompting the persistent question: What causes deep earthquakes? We argue that to tackle this question we need a methodological shift to obtain new observations of deep Earth processes and dynamics, which must be integrated into realistic physical models of slabs. The SODA project introduces deep learning methods to analyse seismological data aiming at improving the detection, characterization and classification of deep events. The outcome will be a new generation of observations offering an unprecedented view of the spatiotemporal evolution (e.g., spatial migrations) of deep events, directly informing us of the physical processes occurring in subduction zones (e.g., fluid movements, aseismic deformation). We will then determine the complex thermal structure, mineralogy, and geometry of subduction zones. Finally, we will use machine learning to unveil the relationships in between our new seismological observations and the modelled physical properties of the slabs, to quantitatively unravel the boundary conditions controlling the occurrence and the dynamics of deep events. The integrated approach of the SODA project will provide an unparalleled quantitative view of the deep Earth dynamics, shedding new light on the physical processes occurring at the mantle level and providing a quantitative assessment of the mechanisms controlling the occurrence and style of deep earthquakes. Our project will thus represent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combinatorial engineering of glycoside hydrolases from the alpha-amylase superfamily' (CEGLYC), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the CEGLYC project is to apply combinatorial engineering approaches to obtain improved enzymes with high catalytic efficiency and better specificity and stability. The selected targets for in vitro molecular evolution techniques are four glycoside hydrolase's from the alpha-amylase super family: amylosucrase, amyl maltase, antigenic alpha-amylase and barley alpha-amylase, which share an identical active site architecture. These improved enzymes will allow the efficient transformation of European renewable agro-resources, starch and sucrose, into highly added-value products of interest for the fields of food and beverages, nutrition and health applications. The project thus conciliates both basic scientific targets; at the level of an improved understanding of glycoside hydrolyse mechanism, and very applied targets, aimed at developing new industrial environmental-friendly bio catalytic processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of nuclear pore and inner nuclear envelope proteins in the regulation of recombination and repair pathways in budding yeast' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

DNA double strand breaks (DSBs) and telomeres both represent ends of a linear chromosome, and both can lead to dangerous genomic rearrangements. Recent studies in budding yeast suggest that persistent DSBs associate with factors in two perinuclear compartments, at nuclear pores and in the inner nuclear membrane (INM). The stability of short telomeres also involves telomere binding to an INM protein, Mps3, and unequal sister chromatid exchange in the rDNA array is prevented by binding another INM protein, Heh1. In the absence of this anchor, rDNA rings are excised leading to premature senescence. From these studies it is clear that the interaction of chromatin with the nuclear periphery contributes to genome stability, yet many questions remain concerning the relocalization and its functional consequences. Are these interactions part of a common mechanism to stabilize or process breaks? Do they cross-talk with each other or do the anchorage sites provide distinct activities specific to the context of the DSB? This proposal will examine the role of nuclear pore and INM proteins in telomere maintenance, rDNA stability and DSB repair, but comparing the outcome of damage at the three sites in various mutant strains. I will use high resolution fluorescence imaging to observe the movement of a randomly distributed DSB to the INM or to pores, which can be distinguished by use of fluorescent tagging and a nup133 mutation. I will determine which repair pathways are regulated by the pores and by INM factors involved in perinuclear anchoring, and finally will investigate whether common mechanisms regulate DSBs processing and the repression of recombination at telomeres or within the rDNA. Intruiguingly all of the nuclear envelope components implicated in this process have homologue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantification of lung cancer risk after low radon exposure and low exposure rate: synthesis from epidemiologic and experimental data' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Occupational exposure to radon in European uranium mines during the last 30 years was at low annual rate; follow-up of 10 000 miners over more than 20 years made it possible to organise a joint analysis. This joint study has a good statistical power, able to detect lom lung cancer risks linked to low annual exposure; modifying factors like attained age, dose-rate, and concomitant exposures (gamma, ore dust) will be studied in this large cohort. Nested case-control studies will be implemented in order to test the radon-tobacco interaction. Domestic radon plus occupational exposure will be studied in one of the case-control studies. Animal experiments will be continued. Mechanistic modelling will be applied to both animal and human data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SMART PUBLIC TRANSPORT INITIATIVES FOR CLIMATE-NEUTRAL CITIES IN EUROPE' (SPINE).

assistant: **Concept**

SPINE’s vision is to accelerate the progress towards climate neutrality by reinforcing PT systems through their smart integration with new mobility services, sharing schemes, active transport modes, and micromomibilty. SPINE adopts an equity centred design thinking approach, leading the transition to a more efficient, sustainable, resilient, and inclusive PT system. A network of collaborative LLs is developed to foster transferability, while an intersectional view of the transport system users is applied. Four Lead City LLs in Antwerp, Bologna, Tallin and Las Palmas will be established, and a series of co-creation activities will take place where multiple stakeholders will be actively engaged in the development and demonstration of efficient, replicable, and socially acceptable innovative mobility solutions, advancing existing assets. The SPINE approach involves the creation of (a) innovative simulation and Digital Twining (DT) tools, along with open data and behavioural models, that will allow the building of scenarios combining different mobility interventions (push and pull measures along with supporting policies) and the implementation of the most promising ones; (b) data-driven impact assessment models that will foster the twinning, transferability and adaptation of the successful solutions of the four LLs in seven Twining Cities - Barreiro, Valladolid, Zilina, Sibenik, Hrakleion, Gdynia and Rouen-. SPIRE sets a high ambitious plan for the co-design and implementation of 55 smart greens inclusive mobility solutions. The SPINE consortium brings together a multidisciplinary team of 39 partners from 16 countries. The unique mix of experienced transport engineers, Public transport Operators, computer scientists, data analysts, transport modelers, social scientists, urb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fundamental Limits of Quantum Mechanics and Physical Laws in a Non-deterministic World' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Quantum mechanics is fundamentally different from all that came before in almost every aspect. But, as far as I can see now, there is one property that stands above all when we try to understand what quantum mechanics is all about: quantum mechanics is our first theory of Nature that is non-deterministic at a fundamental level. Long considered an unpleasant aspect, non-determinism is anything but: Non-determinism enables new freedoms. Phenomena that could not occur in deterministic theories because they would violate some basic laws of nature become possible in non-deterministic theories, under the cover of randomness. A famous example is nonlocality. In a deterministic world, if something acting in one place would instantaneously produce effects somewhere else, it would violate relativity; non-determinism allows it. As in recent years nonlocality/entanglement came to be viewed as one of the main aspects of nature, and as its existence implies non- determinism but not vice-versa, non-determinism itself was seen as secondary. But non-determinism allows many more freedoms. The vision of this project is to change the paradigm, and put non-determinism at the core. The aim is to go well beyond the insights gained from nonlocality and focus on the other freedoms. It will explore very recently discovered situations with indefinite causal order; situations in which the future can affect the past without leading to paradoxes; evolutions subjected to both initial and final conditions; implications for conservations laws, and thermodynamics, the hitherto ignored dynamic nonlocality, etc.  all fundamental aspects of nature in which non-determinism is the key. Finally, quantum mechanics may not be the ultimate theory of nature. The project aims to explore the full extent of the free