RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'IRON-BETA - Unraveling the iron metabolism of pancreatic β-cells' (IRON-BETA) under Horizon Europe.

assistant: **Objectives**

Iron is a critical cofactor for proteins and enzymes involved in oxygen and energy metabolism, functions that are especially vital in pancreatic β-cells. In these cells, iron is indispensable for mitochondrial respiration, the process that powers insulin production. However, disruptions in iron homeostasis - whether through deficiency or overload - have been linked to β-cell dysfunction, yet the underlying mechanisms remain poorly understood. With IRON-BETA, I seek to unravel how iron metabolism regulates β-cell identity, function, and survival, under both normal and stressed conditions, such as type 2 diabetes (T2D) and early post-transplant ischemia. Using cutting-edge techniques and models, including multiplex single-cell RNA-Seq, super-resolution microscopy, ICP-mass spectrometry, novel genetic mouse models, and iPSC-islet cell differentiation, I, together with my team, will comprehensively explore the role of iron in β-cell biology. We will map iron distribution in islet cells, particularly β-cells, to understand its impact on their function and overall islet health. We will investigate how fluctuations in iron availability contribute to β-cell dysfunction in T2D, with the aim of identifying novel therapeutic targets. Additionally, we will optimize iron supply during the maturation of iPSC-derived β-cells to enhance their functional capacity for cell-based therapy. Finally, we will explore the interplay between iron and oxygen homeostasis in β-cell grafts, focusing on hypoxia-inducible factor 1-alpha (HIF-1α) signaling—a crucial regulatory pathway that integrates both iron levels and oxygen availability. By evaluating how iron deficiency and hypoxia impact β-cell survival and graft success during islet transplantation, we aim to improve transplantation outcomes and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MODULAR SYSTEM FOR APLLICATION INTEGRATION AND CLUSTERING IN HOME SYSTEM' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

MOSAIC-HS aims to establish a common standard development for interoperability between two-way radio systems as well as integrated applications covering everyday locations (home, offices, industrial environments, hospitals, rehabilitation centres) relevant to elderly and disabled users. It will implement and test the 'plug-and-play' approach to residential and communicative bus systems in various work/life situations, using a common technology. The first step is an inventory of user needs, and then the development of modules for the user-friendly control of appliances like home alarms and communication/services, using existing cost-efficient elements. The final objective is a prototype integrated multimedia/multimodal, cost-effective personal controller offering direct access to many domestic, hospital and commercial applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advancing the predictability of water cycle through an improved understanding of land surface and coastal water processes and optimal integration of models with observational data' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The Hellenic Centre for Marine Research (HCMR) and team leader Prof. Emmanouil Anagnostou (returning from USA) propose to establish a research team aimed at advancing predictability of water cycle and coastal ecosystem/pollution and improving the consistency of climate change simulations and consequently of our understanding in terms of impacts on water resources.The research team will focus on three major thrust areas:(1) hydro-meteorology/water cycle where the team will seek to address deficiencies in predictability by building an integrative data-modelling system for the simulation of hydrologic quantities and characterizing their uncertainty;(2) coastal ecosystem/pollution where the team will research innovative approaches connecting the water cycle predictions with soil erosion, wetland discharges, terrestrial inputs of inorganic and organic matter in coastal areas, water pollution, and effects on coastal ecosystem structure and dynamics; and(3) climate change where the team will seek to enhance the ability of Global Climate Models (GCM) to simulate vegetation-atmosphere water flux exchanges, thus improve GCMs' skill to predict the impact of surface hydrological processes on the Earth's climate system.We anticipate that successful implementation of the proposed research will yield significant advances and breakthroughs in the predictability of continental hydrologic parameters and climate change science. HCMR puts special emphasis on this proposal, which is considered key to facilitating the successful re-integration of Prof. Anagnostou in Europe through the establishment of an excellence team within HCMR researching advanced concepts on Water Cycle and Climate Change. In support of this proposal, HCMR commits resources to both facilitate and absorb the research wo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Symbiotic, circular bioremediation systems and biotechnology solutions for improved environmental, economic and social sustainability in pollution control'.

assistant: **Concept**

The overall goal of SYMBIOREM is to improve the effectiveness, sustainability, circularity and cost-efficiency of bioremediation and revitalisation strategies for soils, sediments, surface water and groundwater. SYMBIOREM focuses on the intersection of advanced bioremediation methods with circular bio-based systems. Twelve novel bio-based technologies and strategies are developed as modular solutions to mutually enhance bioremediation efficiency, use secondary inputs, and turn residues and contaminants into valuable resources. SYMBIOREM investigates the exploitation potential of indigenous species with bioremediation capabilities, including microorganisms, microbiomes, proteins, plants and animals.SYMBIOREM targets five archetypes of contaminated environments: industrial brownfields, mixed solid waste landfills, urban surface water bodies with mixed contamination, contaminated soils and surface water bodies, and European marine environments. SYMBIOREM targets the four most common pollutants of soil and groundwater in Europe: heavy metals, mineral oil, Polycyclic Aromatic Hydrocarbons (PAH) and Volatile Aromatic Hydrocarbons (VAH). The project also targets mixed contamination, eutrophication, organic micropollutants and microplastic. SYMBIOREM recovers a diverse portfolio of resources from contaminated sites, including several Critical Raw Materials (CRM). SYMBIOREM will deliver new knowledge about bioremediation agents, their functionality in combination, as well as hazards of pollutant remobilisation.  SYMBIOREM elaborates new avenues for circular value creation and empowers people on the ground by involving citizens and key stakeholders in participatory research, co-design and co-management of bioremediation sites, to facilitate bottom-up replication and increased saf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Improve tools and strategies for the prevention and control of classical swine fever'.

assistant: **Innovation**

Although classical swine fever (CSF) has been eradicated in wide areas within the EU the disease is endemic in some new member states particularly in back yard pigs. In order to improve the eradication strategies the project aims are a) the final development and testing of a live marker vaccine candidate for the prevention and improved control of CSF, both orally and intramuscularly applicable; b) the development and optimisation of accompanying discriminatory diagnostic tests; c) the production of an effective, oral delivery system for the marker vaccine for use in wild boar and back yard pigs; d) the easy selection of diseased animals. The improved knowledge on immunological reactions and pathogenesis will support a more efficient vaccine application and provide data for the epidemiological models. Epidemiological studies of CSF in domestic and back yard pigs and in wild boar including molecular epidemiology intend to increase the insight of CSF transmission and persistence. Epidemiological models will be developed to support risk assessment as well for conventional eradication strategies as for new strategies using the new vaccines and diagnostic tools including the role of CSF reservoirs. The results concerning anti-viral treatment will be evaluated and compared with the traditional eradication strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Study on Low-power Multi-Gbps Ultra-Wideband Impulse Radio at License-free UWB and 60GHz bands' under Seventh Framework.

assistant: **Concept**

Ultra-Wideband Impulse Radio (UWB-IR) has an advantage of providing high data-rate with lower power consumption than conventional complex quadrature modulated radios, such as orthogonal frequency modulation (OFDM) with quadrature phase shift keying (QPSK) or 16 quadrature amplitude modulation (QAM). The requirement of large bandwidth is the disadvantage of UWB-IR since license-fee of bandwith requires high cost. But, in 2002, three ultra-wideband frequencies are allocated for license-free applications. From 3.1 to 10.6GHz microwave band called as UWB and 59 to 66GHz millimeter-wave bands are allocated for wireless communication and 22-29GHz pseudo millimeter-wave band is allocated for short-range collision avoidance automobile radar applications. UWB and 60GHz bands are suitable for low-power several Gbps wireless communication. Every day, low-power and high-speed new consumer electronics appliances are appearing in the market such as digital camera, laptop, iPot, etc. These devices need to communicate each other with more than 1 Gbps data-rate where the power consumption of the transceiver is main issue not to reduce the battery life time especially when the communication speed is faster than 1 Gbps data-rate. This research will contain multi-displinary study where we are doing to design radio-frequency integrated circuits, antennas, microwave impulse circuits and customized test structures to study the low-power multi-Gbps UWB-IR. Low-power multi-Gbps UWB-IR at license free bands are going to be investigated for widespread public benefit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Uncovering mechanisms and organization underlying selective regulation of mRNA translation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The gene expression pathway includes transcription, mRNA translation, and protein degradation. Altered translation can rapidly modulate protein levels, without requiring changes in transcription, and can therefore efficiently control cellular responses. Despite evidence of key roles for transcript-selective modulation of translation, the extent and organization of translational control at a transcriptome-wide level is largely uncharted. Moreover, major cancer types appear to be under strong post-transcriptional regulation affecting metastasis and prognosis. TRANSLATOME aims to identify the organization and mechanisms underlying transcriptome-wide modulation of translation. First, I will explore and identify modules whose translation is consistently co-regulated across many cellular conditions, and therefore share common mechanisms, using network module identification. Dependencies between activities of translation modules, which are suggested from the preliminary data, will be studied in detail. This part will exploit polysome or ribosome profiling data from public repositories. Second, I will determine the mechanisms underlying translation modules and how their activities are orchestrated. This will be achieved by identifying RNA features driving the coordinated translation of mRNAs within modules, and how these – via encoded proteins – determine activities in key biological pathways. Finally, I will assess whether modules underlie translation patterns or subtypes of breast and glioblastoma tumours. This interdisciplinary approach requires molecular biology, bioinformatics, systems biology, algorithm development and applied statistics. TRANSLATOME will bring new insights into the transcriptome-wide organization of mRNA translation, which is pertinent to complex disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '3D Living Tissues' to be submitted under Horizon 2020.

assistant: **Abstract**

Prometheus S.r.l. develops and markets 3D human like tissues for regenerative medicine and pharmacological tests. A proprietary 3D Bioprinting Technology enables Prometheus to make use of human living cells as ink, to building up 3D tissues equal for structure and features to the human ones. The human living cells are printed by a strictly controlled process with high resolution, remaining alive during the entire printing process and for a long time beyond. The cutting edge new tissues satisfy the requests of pharma/cosmetic companies to reduce R&D expenditures and times for new products commercialization. Prometheus will go-to-market in Jan 2019 with its 1st product: Ematik, for wounds care. In this framework, Prometheus is undertaking a new business opportunity: a 3D Lymph Node (3DLN) for the testing of new immunotherapies against cancer. The 96% of oncological drugs efficient/safety in preclinical tests, fails human clinical trials, with a 2,5Bln$ expenditure/drug. This high failure rate is due to in vitro tests performed with current unreliable tissues: uncomplete, with different cell composition and compartmentalization respect to the corresponding human once. Contrary, Prometheus’ 3D Lymph Node is equal to the human one for composition, structure and functionality, providing more predictive data. Each company tests 80 new molecules/year and spends ≈4 Mln$ for in vitro tests, excluding animal testing (≈4 Mln$). Market of products for immuneonco testing is estimated in 2Bln€. According to key topics, all potential EU customers yearn to find on the market, asap, at any price, a 3D Lymph Node as the one of Prometheus, whose features allow to rapidly acquire a 4% EU market share in 5 years (40Mln€). During the feasibility study we will assess 3DLN project economic feas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Emergence and decline of constructive memory – Life-span changes in a common brain network for imagination and episodic memory'.

assistant: **Objectives**

The creation of personal, episodic memory from a previous experience is a remarkably complex process, which substantially differs from the processes leading to non-personal knowledge and memory about the world, so-called semantic memory. The act of remembering an episodic event is as much an act of creation as an act of reproduction. Modality-specific memory items are assembled through a re-construction process that allows us to re-experience the episode in rich details. Recent research has shown that recall of episodes and imagination of the future depends on a common core brain network. Early damage to this network will dramatically affect the development of personal memories, effectively preventing the creation of a vivid personal past, while leaving general cognitive development relatively intact. Still, no attempts have been made to study how development and subsequent aging of constructive memory, the arguably most relevant form of memory for daily life-function, is determined by structural and functional properties of the brain. I propose to study how characteristics of the brain determine the development of the ability to form episodic memories in childhood, and how the same factors contribute to the decline in episodic memory function experienced by most healthy elderly. The aim of the current proposal is to understand how maturation and aging of the brain networks for reconstructive memory impacts the ability to form and re-experience ones past. To address this aim, we will study children (4-10 years), adolescents (11-19 years), young adults (20-30 years) and elderly (60-80 years), 100 participants in each group, with repeated cognitive testing and brain scanning with magnetic resonance imaging (MRI). The children will be examined annually, yielding four exami
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Physarum Sensor: Biosensor for Citizen Scientists' under Horizon 2020.

assistant: **Concept**

Imperative utilization of biosensors has acquired paramount importance in the field of drug discovery, biomedicine, food safety standards, defense, security, and environmental monitoring. This has led to the invention of precise and powerful analytical tools using biological sensing element as biosensor. PhyChip has demonstrated an effective and practical technology for using the slime mould Physarum polycephalum as a living transducer in mechanical, optical and chemical sensors. The slime mould maps a wide range of volatile chemicals, tactile stimuli and light of various wavelengths into unique combinations of frequency and amplitude of oscillations of extracellular electrical potential. Given an unknown stimulus one can infer about nature  of the stimulus from the frequency and amplitude of the electrical potential oscillations. PhySense will transform the “lab based” techniques of the slime mould hybrid sensors into `everyday’ use in a cost effective and user friendly format by designing, manufacturing and selling the bio-sensors to research centres, universities, schools and laymen enthusiasts. In addition to making the technology accessible to both the general public and non-specialists this transformative project will establish an online portal capable of collecting and sharing millions of measurements. Recent work by our group has already developed a working prototype --- based on low cost electronics and bespoke software --- which demonstrate the paradigm shift which this project offers. Citizen participation will be used to leapfrog years of traditional research catapulting Europe in the driving seat of this exciting new scientific frontier of living technologies in sensing and computing.


**Keywords:** unconventional computing, biosensors, living technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'System design industry council of European telecom industries' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The European telecom industry has agreed that system design know-how, being one of their main assets, cannot be reused effectively enough today because of the increasing complexity of the systems, fast evolution of technologies and increasing demands for performance, low cost and short time-to-market. The project objective is to provide a solution to the problem of making the know-how about system design more usable, sharable and preservable ? yet protected. The project will focus on the reuse methodology at the system level, not at the implementation level. The first step will be the characterisation of the current design flows of the partners in order to obtain an agreement on concepts and terminology and to identify the principal problems and inefficiencies. Next a common system-level conceptual model will be developed in the form of a reference frame on which to build a methodology including a systematic and efficient way of using system level IP. For that an assessment procedure with telecom domain application benchmark and assessment guidelines will be defined and tested. A requirement analysis and definition of system level design languages and formalisms will be made to constitute, together with the conceptual model, the selected formal support of the methodology. The results will be provided for RTD projects as well as promoted in relevant standardisation bodies.