RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pickering emulsions for food applications' (PICKFOOD).

assistant: **Concept**

Enormous food waste worldwide has huge environmental and cost efficiency impact. Chemical deterioration caused by e.g.oxidation of lipids, vitamins and other food constituents are causes of waste. Many foods are emulsions stabilized bysurfactants. Conventional surfactants have dominated emulsion science due to their ease of use, relatively low cost andcontrol. However, their future industrial use is under threat, because of formulation foaming problems and the need to reducevolatile organic compounds and carbon footprints. The use of so-called Pickering particles for production of physically andoxidatively stable emulsions may be a solution to these problems. The aim of the Pickering Emulsions for Food Applications- PICKFOOD project is therefore to provide a framework and novel methodologies to study and develop Pickering emulsionsand to evaluate their applications in safe, healthy and functional foods in collaboration with the food industry. Achieving thisgoal involves a combination of soft matter physics and food colloid science deepening our physical understanding ofemulsion stability and processing, preparation of food-grade Pickering particles as well as characterizing them by highlyadvanced methods not traditionally used in food science. Moreover, physics and food science will join forces inelectrohydrodynamic processing to avoid the deterioration of thermo-sensitive compounds during encapsulation since thesolvents are evaporated at low temperature. PICKFOOD assembles a multisectorial team of scientists to train youngresearchers, and provide them with the combination of skills from soft matter physics and food colloid science. We want tospecifically provide them with technological and methodological competences to advance the field of Pickering emulsions forfood p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Tracking and Targeting Tumor States at single-cell resolution in real time in vivo'.

assistant: **Objectives**

It is now widely recognized that within a tumor, not all cancer cells are alike and different tumor states (TS) exist. This process is known as tumor heterogeneity. Some cancer cells actively proliferate, while others differentiate, migrate and give rise to metastasis, or enter in a dormant state and resist to chemotherapy. The identification of distinct TS and the mechanisms that regulate their identities and functions is critical for our understanding of tumor heterogeneity. The different TS can acquire distinct phenotypes responsible for tumor progression, metastasis, and therapy resistance. In this project, using multidisciplinary approaches that combine single-cell lineage tracing, single-cell genomics, epigenomics and transcriptomics together with pharmacological treatment and genetic perturbations, we will define in a comprehensive and integrated manner the identities and functions of distinct TS at single-cell resolution in squamous cell carcinoma (SCC). Then, we will develop new genetically engineered tumor models expressing different fluorescent proteins to visualize the dynamics of TS in real time in vivo using intravital microscopy. Moreover, we will assess the roles of the identified TS by lineage ablation and identify the intrinsic and extrinsic mechanisms that regulate their transitions and functions, which will help to define new tumor vulnerabilities and provide new therapeutic opportunities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'My personal adaptive Global NET and beyond'.

assistant: **Concept**

The MAGNET Beyond vision is to make the MAGNET concept a reality, that is Personal Networks (PNs) will support users? professional and private activities, without being obtrusive and while safeguarding their privacy and security. The MAGNET Beyond mission is to make MAGNET happen by enabling commercially viable PNs that are attractive, affordable and beneficial for end-users in their everyday life. The MAGNET Beyond project constitutes a system approach to what is expected to be one of the most important telecom related growth markets of the future, Personal Area Network (PAN) style networking.The MAGNET Beyond project builds on the results of MAGNET and providing advances in PNs that include:- Research-based, comprehensive, short-term and long-term solutions for the technologies and protocols needed to build Personal Networks that meet the user requirements, in particular in terms of the quality-, security- and trust requirements.- Technology roadmaps for the evolution of Personal Networks.- System specs for first generation Personal Networks.- Effective platforms that optimally and cost-effectively meet the short- and long term communication requirements for personal devices.- A pilot Personal Network system and pilot services.- An assessment of the market potential of Personal Networks based on PN services usage, usability and acceptation tests.MAGNET Beyond will introduce three Pilot Services, obtain real market and user feedback and help build the business of personal services over personal networks. MAGNET Beyond will strongly promote PNs and related technologies and provide input and recommendations to standardization and regulatory bodies and fora. Through success in the MAGNET project, Europe can leverage its leadership in wireless towards new business opportun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Natural Food formulation for the prevention and treatment the Obesity and Metabolic Syndrome obtained with herbal extracts'.

assistant: **Concept**

Monteloeder is a global developer, manufacturer and distributor of ingredients and formulations for the nutrition and cosmetics industry. It is committed to identifying and developing safe and effective ingredients derived from natural plants that deliver measureable benefits to consumers. Founded in 1996, Monteloeder today has sales in more than 38 countries and operates offices in Europe, US and Asia. INNOPREFAT is the result of a long process led by Monteloeder to discover a natural solution to address one of the major epidemics of our time: Metabolic Syndrome (MetS). MetS can lead to serious diseases and conditions, including diabetes type-2, stroke, Alzheimer’s, cancer and heart disease. It affects more than 25% of the world’s population and represents a major and escalating global public health problem and clinical challenge. In Europe, about 8-18% of total adult healthcare expenditure is metabolic syndrome related. The Business Model and the solution (MetabolAid®) are built around three dimensions: 1. A superior quality product based on a synergistic blend of two herbal extracts, which is supported by an extensive and rigorous scientific programme that demonstrates its effectiveness in improving MetS, as well as its safety and its economic viability. 2. A fully traceable, transparent and efficient supply chain, which guarantees that the product is natural, sustainably produced, completely safe and that it can be included in the main food matrices. 3. Global marketing approach includes a novel and original strategy: we will support our B2B clients with mobile phone health technology to manage end-consumer’s experience with the product and improve their levels of compliance, which in turn will enhance efficacy. Monteloeder believes that those are the dimensions tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Globular cluster dynamics explored by parallelised codes for image restoration and crowded-field photometry' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content What is the number and population of binary stars in the core regions of Globular Clusters? It expected from dynamical simulations that post core-collapse clusters have many binaries, but so far fe have been discovered. We are conducting a unique, systematic photometric survey for core binaries outburst, with our 2nd-generatio4 multiband high-resolution camera. HST/WFPC2 images provide t astrometric positions of thousands of stars, vastly reducing profile-fitting photometric scatter. Howeve the resulting CPU/memory requirements mean that only high-performance parallel computing faciliti can exploit this - and similarly, our deconvolution-based star-detection technique - without introduci edge-effect errors. We propose therefore to parallelise various codes for image restoration al photometry. This will yield optimal photometric datasets and subtracted images. We will search the for characteristic binary behaviour. This process also yields further science - the most comprehensifl survey yet of intrinsic variable stars in the central regions. The acquisition of the required imagery h already been arranged. Training content (objective, benefit and expected impact) EPCC (Edinburgh) is a leading training organisation in scientific computing. Their frequent cous would help me to write the best parallel code and benefit my overall computation skills. My host group would teach me their simulation methods, expanding my competence to new fields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Memory Practices of the Afghan and Somali Diasporas in the USA and Italy.' to be submitted under Horizon Europe.

assistant: **Abstract**

Memory is a crucial resource for people in exile who have to deal with new and often hostile environments, since it keeps their transnational ties alive and shapes their collective identifications. Memory, however, is today increasingly subject to challenges, rearticulations and negotiations, especially when it refers to individual and collective practices, more and more confronted with global dynamics. MEMODIAS aims to explore these dynamics through an ethnographic inquire on the memory of conflict, exile and return among Afghan and Somali diasporas in Italy and the USA. Reflecting my previous mixed experience as researcher and practitioner in the field of migrant memories, my project enhances the implementation of participatory research methods and practices which can facilitate a circularity between the researcher and diaspora members as “co-researchers”. While exploring the interdiasporic forms of mnemonic solidarity in the transnational space between US and Italy, the project’s scientific and societal impacts will be strictly entangled and interdependent.  MEMODIAS overall theoretical framework draws from Memory and Migration/Diaspora studies, Media, Art and Performance studies, Cultural studies, and Critical Global studies, subjects of my training activities which will include Gender studies. Research methods will be particularly focused on self-narrative practices. This approach will enhance the capability of participants to become active in policy making processes and to envisage new future possibilities of cohabitation. MEMODIAS dissemination and communication target scholars (through scientific publications), diasporas members, policy makers, journalists, educators and a broader public (through social media, civic events and an educational toolkit). Inspired b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ubiquitin Chains in Viral Infections' (CHUbVi).

assistant: **Innovation**

Viruses such as Influenza A (IAV) and others remain one of the greatest threats to human health and society. Despite their danger and widespread prevalence, the molecular mechanisms of how they infect mammalian hosts and evade the immune system remains poorly understood. Recent studies from our team implicate two common proteins – HDAC6 and unanchored ubiquitin chains – in host cells as key mediators of viral entry via the aggresome processing pathway. This discovery offers a new line of investigation for understanding and preventing viral infections. By identifying the pathways and interactions involved in this infection process, we will provide new molecular targets for the development of broad-spectrum antiviral compounds. Multidisciplinary studies by a team consisting of a molecular biologist, a virologist, and a chemical biologist will use a diverse set of tools to validate these pathways and gain fundamental knowledge about their regulation. To achieve this, detailed studies on the exact nature of the ubiquitin chains needed to activate HDAC6 will allow the development of biochemical and cellular assays of Influenza A infection and enable the determination of the precise mechanism and the downstream cellular pathways necessary for viral infection. The chemical synthesis of labeled ubiquitin chains will support detailed structural studies and a clear understanding of how they are formed and packaged into infectious viral particles. The strong possibility that numerous other virus types also utilize this pathway will be tested with life-threatening agents of current concern including Zika, Dengue, Ebola, and MERS viruses. By demonstrating – with both biological approaches and small molecule compounds – that blocking these cellular processes in cells and animal model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploring the non-genetic (i.e. ePIgenetic) mechanisms that contribute to therapy Escape in melanoma' (EscaPI), addressing dissemination and exploitation.

assistant: **Impact**

Resistance to anticancer drugs, which often develops from a heterogeneous pool of drug-tolerant cells known as minimal residual disease (MRD), is thought to mainly occur through acquisition of genetic alterations. Emerging evidence indicates that drug resistance may also be acquired in absence of a genetic cause. It remains unclear, however, whether genetic versus non-genetic mechanisms of resistance are selected in a stochastic manner, and what are the epigenomics mechanisms underlying the transition from drug-tolerance to resistance. This project aims at identifying the drug-tolerant subpopulation(s) that drive non-genetic resistance by performing lineage tracing and depletion experiments in pre-clinical models. Taking advantage of up-to-date technologies combining in vivo barcoding and single-cell multi-omics approaches, this project aims to provide a dynamic and integrated view of the evolution of epigenomic profiles -at single-cell resolution- before, during and after acquisition of drug resistance phenotypes in a in vivo clinically-relevant context. A third objective of this proposal is to search for predictive biomarkers of non-genetic resistance and to assess the percentage of melanoma patients that undergo non-genetic resistance through combination of multiplexed staining and targeted DNA sequencing. The success of this project is ensured by my personal background in epigenetics and related data computational analysis, the achievements of the JCM lab in melanoma epigenetic reprogramming and the close collaborations with experts in single-cell multi-omics fields. I anticipate that my involvement in this project will broaden my skills and knowledge and help me become a high-qualified European independent scientist.


**Keywords:** non-genetic mechanisms of resist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dynamics of the evolution of antimicrobial drug resistance (DEAR)' to be submitted under Fifth Framework.

assistant: **Abstract**

To predict the development, spread and reversibility of ant microbial drug resistance we need to understand the different microbial, host and treatmentparameters that determine rate and trajectories of these processes. This application is aimed at experimentally defining these parameters. Thus, we will determine which factors are important for determining1) the rate of antibiotic resistance development, and2) the stability of antibiotic resistance. In addition, we will3) examine strategies to slow down the rate of antibiotic resistance development by altered treatment regimens. Results from this application are expected to help in describing, predicting and preventing antibiotic resistance development in significant human pathogens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'How Bone Adapts to Heavy Weight? Bone Morphological and Microanatomical Adaptation to the Mechanical Constraints Imposed by Graviportality'.

assistant: **Objectives**

Heavy animals, said to be graviportal, are under strong mechanical constraints. Their skeleton, notably their limb bones, show convergent morpho-functional adaptations that surprisingly remain very poorly studied. Understanding the convergent and specific adaptations of bone to weight bearing in taxa with various morphologies, sizes, habitats and locomotor behaviours is essential to understand how bone responds to biomechanical constraints. In palaeontology, it will allow determining how giant fossil animals could move and support their weight. The study of graviportality provides an ideal case-study to analyse form-function relationship in a macro-evolutionary context.GRAVIBONE proposes a broad and modern comparative investigation of the biomechanical adaptations of the outer and inner bone anatomy of long bones observable in different modern and fossil taxa that have converged on graviportality. It combines various approaches using recently developed powerful methods and tools (notably the innovative integration of the whole 3D external and internal bone anatomy in biomechanical modelling) and uses these in an explicit phylogenetic context. Characterizing the various adaptive traits observed in extant taxa and understanding the link between specific isolated microanatomical, morphological and mechanical parameters will enable to: a) define degrees/types of adaptations to graviportality, b) make palaeoecological and paleofunctional inferences, and c) explain adaptations to graviportality in amniote evolutionary history. This new and highly integrative approach will increase our knowledge on the adaptation of the vertebrate skeleton and thereby of the organisms, to environmental demands.


**Keywords:** Functional Anatomy, Bone Adaptation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unraveling the regulatory code of gene expression in plants' in the context of a Horizon Europe call.

assistant: **Objectives**

Multicellular plants control the fine-grained expression of thousands of genes during growth, development, and in response to external stimuli. While gene expression varies strongly between different organs and tissues, how this specificity is encoded in the genome is largely unknown. Although various regulatory DNA sequences and sequence-specific transcription factors controlling diverse transcriptional responses have been described, the combinatorial nature of the regulatory code makes the application of rational approaches to learn and predict context-specific gene expression challenging. This is a major obstacle towards engineering plant promoters with predictable and tuneable expression.multiCODE’s aim is uniting single-cell genomics, explainable artificial intelligence (xAI), and synthetic promoter engineering, to efficiently learn and validate regulatory sequences controlling gene expression in plants. Based on high-resolution single-cell gene expression profiling in the model Arabidopsis and the crop Brassica rapa, xAI models will be built to predict gene expression in leaves under control and stress conditions while at the same time identifying the underlying regulatory DNA sequences and syntax. The power of these predictive models will be validated by exploiting inter- and intra-species sequence variation, revealing the evolutionary conservation of the regulatory code. Furthermore, a novel multi-tier synthetic promoter engineering approach will be used to experimentally validate, directly in plants, the learned regulatory code in a high-throughput manner. By combining the power of advanced computational and experimental methods, I will identify novel regulatory sequences and design novel synthetic promoters controlling gene expression in complex cellular conte