RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SmartMarker - Clinical Validation of Biomarkers by Smart Data Analyses' to be submitted under Horizon 2020.

assistant: **Abstract**

The overall goal of SmartMarker is the development of a commercial infrastructure that allows to transform heterogeneous patient health information, typically stored in multiple clinical and health IT systems, into standardized, comparable, consistent, and queryable data. The ultimate goal of this infrastructure is to conduct retrospective clinical biomarker validation studies and to foster effective treatments to marker-defined patient subgroups. Exploitation of the electronic medical records will allow pragmatic and low cost, but still robust and appropriate analytical retrospective study methods to measure the prognostic and predictive outcome of clinical biomarkers. SmartMarker will dramatically ease the process of clinical biomarker validation in the cardiology domain. Ischemic heart disease is the leading cause of death in the developed world. The primary biomarker used to identify patients at high risk of sudden death is the ejection fraction. Brain natriuretic peptide is a useful biomarker for predicting the presence of heart failure, risk of readmission and mortality. However, only few biomarkers have been rigorously validated in clinical routine, and few of these markers have been integrated for identifying high risk cohorts in routine clinical practice. This led to a widening implementation gap between recommendations from national and international guidelines and actual routine clinical practice. With SmartMarker we want to close this gap and achieve best-possible outcomes for the patients. We will validate the link between already existing clinical biomarkers in cardiology that are collected on a daily basis in the clinical routine and pertinent clinical endpoints. Finally, we bring forward effective treatments to marker-defined patient subgroups.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SocialRobot' (SOCIALROBOT) under Seventh Framework.

assistant: **Objectives**

The main goal of the proposed project is to provide an answer to the demographic change challenge, through knowledge transfer and the creation of strategic synergies between the project’s participating academia and industry regarding the development of an integrated Social Robotics system (SocialRobot) for “Ageing Well”.The work focuses on bringing together the Robotic and Computer Science fields by integrating  state of the art Robotic and Virtual Social  Care Communities technologies and services to provide solutions to key issues of relevance for improved independent living and quality of life of elderly people and efficiency of care.The SocialRobot development will be based on a “human centred approach” in which the elderly individual needs and requirements are met. The project will give the opportunity to participating SMEs with excellent credit in their domain and peripheral European regions, to reach excellence and compete with innovative products in the elderly care market, at European and International level.The major challenges to be addressed in the project include the adaptation of state of the art robotic mobile platforms and their integration with a virtual collaborative social network to provide:Detection of individual needs and requirements related to ageing (e.g. physical mobility   limitations or/and cognitive decline), and provision of support through timely involvement of care teams, consisting of different groups of people (family members, neighbors, friends) that collaborate dynamically and virtually; means independently of time and their physical locations; Behavior analysis to adapt social relationships and contexts of the elderly people as they age.Navigate indoors and unstructured environments and provide affective and empathetic user-robotic i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Joint European Data Resource for Human Genome Research' (EDR) targeting Fourth Framework.

assistant: **Abstract**

The European Data Resource (EDR) will provide on-line access to the most important databases in the field of genome mapping, sequencing and analysis, to network services and general information retrieval tools, up-to-date software for the scientific evaluation of genomic data, sequence analysis, mapping, etc. It will upgrade the high-speed network and establish an ATM protocol connection between the EDR nodes. We will make available the services of the EDR for a large user community. At the moment, the EDR serves as a data resource for more than 5000 users. By the end of the proposed time phase the EDR shall serve as a data resource for 10 to 12,000 users. EDR will support the Integrated Genomic Database (IGD) as a comprehensive software system for the human genome community, help the integration of further data into the IGD, the maintenance of the central IGD server, in co-operation with and support of further IGD server nodes in Europe. Furthermore, it will provide and support telephone hot-lines, electronic-mail, a regular newsletter, database and software documentation, training workshops, technical courses and scientific meetings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Flexible Change Management for the Factory of the Future'.

assistant: **Concept**

In the today's increasingly uncertain environment, production managers need new methods and tools to support them on decisions about planning, monitoring and changing a production system. The ability to change and adapt under both external and internal fluctuations is often referred to as the flexibility degree of the system. The X-CHANGE project aims at devising and integrating flexibility measures into decision support processes for lifecycle and change management, thus providing a modelling and software framework for enhancing the effectiveness of the European industry.The main objectives of the project area) to develop an innovative, LIVE flexibility modelling and analysis methodology with wide applicability range andb) to materialize this methodology into an OPEN-INTERFACE SOFTWARE FRAMEWORK able to facilitate lifecycle and change management in production systems and extended enterprises that operate in dynamically changing environments.X-CHANGE will primarily focus on evaluating flexibility for providing decision-support in the management and planning of short and mid-term changes of a manufacturing system, addressing production and business processes in a multi-level structure. Lifecycle and changeability management upon long-term scenarios will also be addressed. X-CHANGE will utilize production and business data for a number of processes - such as changes of work pieces and tools, CNC reprogramming, changing machines loading, investing on new equipment or labour - as well as information related to the production facilities operation, product orders, suppliers, transportation and inventory logistics.The consortium includes manufacturers from diverse sectors, thus cultivating the development of generic/global solutions, software companies that are already active
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Crossmodal estimation of decisions, guesses and delays in decision making: a collaboration between psychology, physiology and artificial intelligence' (CrossEDGE).

assistant: **Concept**

Our daily lives are full of decisions for which we could take an infinite time in order to decide as accurately as possible. However, different speed and accuracy constraints, tied to the type of decisions, the decision-maker and his environment, are limiting the time allocated. How decision-makers deal with this speed-accuracy tradeoff is an important cornerstone for the sciences studying decision making such as psychology, cognitive neuroscience and artificial intelligence. One particularly successful proposal of formal decision-making models is to assume that decision-makers are reducing or increasing decision thresholds to adapt to the speed and accuracy constraints. But recent evidence shows that this strategy is insufficient to explain the full range of behavioral and physiological data in decision tasks. The present proposal suggests, based on new studies, that speed-accuracy tradeoff is achieved by varying the reliance on three different response strategies: guessing, immediate evidence accumulation and delayed evidence accumulation. Using an interdisciplinary approach, involving experimental psychology, mathematical psychology along with cognitive neuroscience and artificial intelligence, the project aims at providing a broadly applicable framework to detect, measure, and estimate the reliance on the three strategies along with the description of the psychological processes behind these. This project will train a promising cognitive psychologist and neuroscientist to apply advanced methods in a unique and fruitful research environment linking the four disciplines. It will also provide the host organisation with new tools to study latent cognitive processes in cognitive tasks. Overall, the project will constitute an innovative approach to decision making with br
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Resilient northern overturning in a warming climate'.

assistant: **Innovation**

A vigorous Atlantic Meridional Overturning Circulation (AMOC) is crucial for the mild northern European climate; it brings warm water northward near the surface and returns cold, dense water at depth. In a warming climate the AMOC is projected to weaken  or even approach a tipping point. Contrary to this established view, I hypothesize that an overlooked, climate-change induced mechanism may impart resilience to the overturning: As the sea ice recedes, increasing stretches of the boundary current system around the Nordic Seas and Arctic Ocean become exposed to the atmosphere. The resulting increased ocean heat loss in winter further densifies the water in the boundary current, which is a direct pathway supplying the lower limb of the AMOC. Enhanced dense-water formation is counter-intuitive in a warming climate and not represented by current climate models, but has the potential to safeguard the northern overturning and maintain a steady supply of dense water to the AMOC. Sparse observations and preliminary results from a 1D model indicate that water mass transformation occurs in the increasingly ice-free boundary current, but its extent, importance, and future development are unknown. In ROVER, I will explore this concept through an extensive field campaign, which includes a mooring array across the boundary current and an unprecedented wintertime survey of this severely under-sampled area. Combined with targeted high-resolution modeling, I will use the comprehensive data set to document the occurrence of this process, understand its dynamics, quantify its extent, and assess its climatic importance. Dense-water formation in the boundary current system that may safeguard the northern overturning would represent a paradigm shift for water mass transformation at high lati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bulgarian centre of excelence in plant biotechnology' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The nomination of the Institute of Genetic Engineering as a Centre of Excellence, will allow conducting of set of specific measures, adding essential opportunities to reach its goals:-further development as a National Plant Biotech Centre for high-output plant cell and molecular genetics research;-to provide the expertise and to coordinate plant biotechnology activities in the country;-to provide transfer of up-to-date plant biotechnologies and to cooperate with international research centres, universities, plant biotechnology companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CARdiac tissue Design, beating INduction, and Assessment using multiwavelength Light (CARDINAL)' (CARDINAL).

assistant: **Concept**

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Chronic treatments of CVDs are scarce because of poor predictivity of current two-dimensional (2D) pre-clinical models. State-of-the-art 3D-tissue models based on human induced pluripotent stem cells (hiPSCs) can be more predictive of human genetics but fail to replicate the 3D cardiac muscle structure. In fact, the heart evolved to ensure efficient emptying of the chambers via a 3D chiral organization of muscle tissue not yet recapitulated in organoids or engineered ventricles. In CARdiac tissue Design, beating INduction, and Assessment using multiwavelength Light (CARDINAL), I will replicate the native chiral architecture of the heart in a minimal 3D model of the heart muscle and validate the resulting assay for drug screening. Our objectives will tackle three main challenges in the field:1)Create the chiral scaffold to host the hiPSC-derived cardiac muscle cells (hiPSC-CMs). I will use cavitation molding - a light-based 3D-structuring method I previously developed - to obtain chirally organized micro-channels in soft hydrogels. 2)Populate these scaffolds with high-purity hiPSC-CMs that can be triggered and assayed with optical methods. I will leverage the host lab's engineered hiPSC line that features structural and functional fluorescent sensors. To that line, we will add optogenetic actuators and antibiotic resistance to directly control the final hiPSC-CM yield, trigger contraction, and image cell structure and function volumetrically.3)Validate the predictivity of our new 3D chiral platform in drug screening applications. To do that, we will test a panel of cardiac drugs with known safety/efficacy profiles with our new platform, 2D hydrogels, and traditional glass slides.  The CARDINAL proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanical regulation of tissue growth and signalling' (MRTGS) under Horizon 2020.

assistant: **Objectives**

The control of tissue size and morphology is a fundamental problem that is remarkably ill understood. Although extensive research has focussed on the genetic and biochemical control of tissue growth, significantly less attention has been paid to the mechanical aspect of growth regulation, even though ample evidence indicates that any deformation or shape change is, to some degree, a result of force acting on a mass. Unravelling the basis of the mechanical-biochemical co-regulation in tissue growth control will not only increase our understanding of organismal development but also potentially represent a novel therapeutic target in growth-related diseases such as cancer. With this in mind, I aim to address two central questions: 1) How do mechanical stresses generated by growing tissues impact signalling networks to modulate tissue growth and morphology?2) What is the function of in situ mechanical force on normal tissue growth and 3D architecture?Using the Drosophila wing disc as the model tissue, I will employ a combinatorial biophysical, molecular, genetic and computational modelling approach to address the proposed questions. With a novel tissue stretching and compression device, I will initially identify key signalling events mediating the growth responses downstream of mechanical force. In parallel, by individually altering the genetic or the mechanical properties of the system, I will address co-regulation between mechanics and tissue growth. My research will lay the foundations for our understanding of tissue growth control by mechanical forces - a finding that may ultimately help to design novel treatment strategies for cancer. The classical approach to restrain cell growth involves targeting of the underlying genetic defect; however it might be more advantageou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structure function relationships of the phyllosphere microbiota', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Understanding processes in microbial communities is a crucial task given the impact of microbial communities on environmental systems, including plants and animals. There is a rapidly increasing number of microbial communities whose collective genomes have been determined; however, it is important to uncover their collective function and to understand how community properties emerge from the properties of individual microbial types and their interactions. One habitat that has been gaining growing interest is the phyllosphere, or the aerial parts of plants, which carry out the majority of terrestrial carbon dioxide fixation. There is a urgent need to better understand the microorganisms living in the phyllosphere and an increasing awareness of the importance of indigenous microbiota and their role in microbe-microbe and host-microbe interactions for both plant growth and protection. This project aims to uncover the molecular basis shaping microbial communities in the phyllosphere in order to improve our functional understanding of microbial interaction in the context of the plant host and to unravel the principles of the formation of community pattern and function in situ. To reach these objectives, a reductionist approach will be used to generate and test new hypotheses regarding microbial interactions in phyllosphere communities. Synthetic, tractable microbial communities will be formulated and analyzed under gnotobiotic conditions. In situ community approaches will be developed and applied, while community genetics and experimental evolution will provide complementary perspectives on the community structure and function. These approaches will be mirrored by manipulating interactions on the host side through the use of plant mutants and ecotypes. Taken together, using
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'ACTIVE AGEING – RESILIENCE AND EXTERNAL SUPPORT AS MODIFIERS OF THE DISABLEMENT OUTCOME'.

assistant: **Objectives**

The goals are 1. To develop a scale assessing the diversity of active ageing with four dimensions that are ability (what people can do), activity (what people do do), ambition (what are the valued activities that people want to do), and autonomy (how satisfied people are with the opportunity to do valued activities); 2. To examine health and physical and psychological functioning as the determinants and social and build environment, resilience and personal skills as modifiers of active ageing; 3. To develop a multicomponent sustainable intervention aiming to promote active ageing (methods: counselling, information technology, help from volunteers); 4. To test the feasibility and effectiveness on the intervention; and 5. To study cohort effects on the phenotypes on the pathway to active ageing.“If You Can Measure It, You Can Change It.” Active ageing assessment needs conceptual progress, which I propose to do. A quantifiable scale will be developed that captures the diversity of active ageing stemming from the WHO definition of active ageing as the process of optimizing opportunities for health and participation in the society for all people in line with their needs, goals and capacities as they age. I will collect cross-sectional data (N=1000, ages 75, 80 and 85 years) and model the pathway to active ageing with state-of-the art statistical methods. By doing this I will create novel knowledge on preconditions for active ageing. The collected cohort data will be compared to a pre-existing cohort data that was collected 25 years ago to obtain knowledge about changes over time in functioning of older people. A randomized controlled trial (N=200) will be conducted to assess the effectiveness of the envisioned intervention promoting active ageing through participation. The p