RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dams and Dolphins: Linking cutting-edge science with endangered species conservation' (RIDDLE) under Horizon 2020.

assistant: **Objectives**

This Fellowship application is crafted to bring together cross-disciplinary expertise and technology to help solve the challenge of sustaining river dolphin populations and other aquatic megafauna in dammed and regulated rivers. This is based on the recognition that freshwater habitats occupy only 1% of the Earths surface yet support 10% of all known species, but that freshwater species are now even more endangered than those in marine or terrestrial ecosystems. Freshwater dolphins are one of the most threatened mammal groups; listed as endangered or critically endangered in all places they occur, and the cause of their decline is attributed to habitat fragmentation by gated dams. The goal of this work is to quantify the extent, evaluate the consequences, and pilot solutions to understand and address river dolphin population connectivity in rivers fragmented by dams. To accomplish this acoustic and biotelemetry technology will be adapted and deployed at key gated dams in South Asia to monitor and quantify dolphin movement through the dams and two new options that have the potential to prevent river dolphins from passing through dam gates will be trialled. The results will have applications on the ground for the management of endangered riverine species, and the technological component has broader applications in assessing and potentially mitigating the impacts of marine engineering projects on the aquatic environment. The work falls at the interface between marine and freshwater ecology and will be conducted under the guidance of Dr Simon Northridge in the Sea Mammal Research Unit at the University of St. Andrews. The ability to move from my current research post in Tanzania into a vibrant academic community within the EU will allow me an unprecedented opportunity to di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DISKOmice' (DISKOMICE).

assistant: **Innovation**

We hypothesize that within the intervertebral disc (IVD), a niche exists comprising the nucleus pulposus and the inner layer of the annulus fibrosus and the cartilage endplate. In the niche, two events govern successful maintenance of disc cell function: the ability of progenitor cells to provide replacement cells, and the power of this cell population for renewal.  In the disc niche, environmental conditions are unique in that the progenitor cells experience a low oxygen tension and possibly a low pH.Cellular adaptation to low oxygen (hypoxia) is an important biological problem not only in relation to pathological conditions such as cancer and ischemic diseases, but also in normal foetal development and in cell differentiation.The overall goal of this project is to investigate the role of hypoxia and HIFs transcription factors and the molecular mechanisms that are involved in the biology of IVD, especially in proliferation, survival, differentiation of NP cells and formation of NP tissue, in both developmental and degenerative processes.To achieve this aim, the proposed research activities will focus on:  mice models of gene invalidation particularly regarding the HIF pathway (HIF-1α, HIF-2α and Von Hippel Lindau tumor suppressor protein). To specifically inactive these genes during embryonic development, growth or aging, conditional and inducible KO will be generated using Cre or Cre-ERT2 strategies and promoters for Foxa2 (notochordal cells) or aggrecan (NP cells).The expected results are to improve our understanding of IVD development, aging and associated pathologies. Such advances in the comprehension of IVD physiopathology may lead to the development of advanced approaches by defining novel therapeutic targets and/or innovative cell-based tissue engineering strat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ageing and Reliability Testing and Monitoring of power cables: diagnosis for Insulation Systems' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content Electric power transmission needs reliable high voltage AC (HVAC) power grids, with a current trend towards an increase in buried links. This market evolution is a response to strong environmental pressure to reduce the use of overhead lines. There is a growing need for extra-HV (EHV) cross-linked polyethylene (XLPE) cables (400/500 kV), especially in urban or crowded areas, as fluid filled cables are no longer used for new installation due to electrical, maintenance and environmental reasons. The technical limitations of HV and EHV XLPE cables, related to uncertainties in reliability (i.e.: poor understanding of degradation mechanisms), led to an over-dimensioning of cables and thus higher installation costs. In addition, with respect to overhead lines, the cost of underground cables is at present higher, with an increasing threat from Asian competitors: due to reduced manpower costs, they are in a position to provide cheaper final products. European cable manufacturers will face this challenge by offering cost effective solutions to the utilities, including turnkey systems and improved product quality. A thorough understanding of ageing phenomena is required in order to guarantee long term reliability and ultimate life time prediction. More reliable power links are needed: some cables have been operating for over 20 years, with an expected 30 years life (and a need for further life extension). Premature ageing could be a cause for unexplained failure: the present rate is 0.8/100 km/year; an objective is to reduce it to 0.2. This target can only be reached through the development of an efficient Diagnosis System. The main objectives of the project are therefore:  to assess the state of ageing of cable materials under combined stresses, 2/ to deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Collaborative Open Market to Place Objects at your SErvice' (COMPOSE) under Seventh Framework.

assistant: **Objectives**

The COMPOSE project aims at enabling new services that can seamlessly integrate real and virtual worlds through the convergence of the Internet of Services with the Internet of Things. COMPOSE will achieve this through the provisioning of an open and scalable marketplace infrastructure, in which smart objects are associated to services that can be combined, managed, and integrated in a standardised way to easily and quickly build innovative applications.The COMPOSE project builds upon existing European research projects and ongoing standardisation activities to provide a comprehensive marketplace framework that will be able to cover the whole service lifecycle by integrating a number of innovative technological enablers in a coherent way. The project will develop novel approaches for virtualising smart objects into services and for managing their interactions. This includes solutions for managing knowledge derivation, for secure and privacy-preserving data aggregation and distribution, and for dynamic service composition advertising and discovering objects' capabilities and service provisioning and monitoring.The COMPOSE project is expected to give birth to a new business ecosystem, building on the convergence of the Internet of Services with the Internet of Things and the Internet of Content. The COMPOSE marketplace will allow SMEs and innovators to introduce new Internet of Things-enabled services and applications to the market in a short time and with limited upfront investment. At the same time, COMPOSE will allow major European players in the information and communication industry, particularly cloud service providers and telecommunications companies, to reposition themselves within new Internet of Things-enabled value chains.The COMPOSE consortium comprises twelve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Electrochemical energy and environmental systems' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Applications are invited from PhD students in science or engineering to apply for Fellowships to undertake short to medium term periods of research training, at a new European training Site, in ELECTROCHEMICAL ENERGY AND ENVIRONMENTAL SYSTEMS. Periods of stay are variable and can be from 3 to 12 months depending upon training needs and experience of visiting fellows and can be at any time during the successful fellow's PhD studies. Fellows will receive a stipend of 1200 Euro per month, intended to supplement existing funding from the fellows home University, and a contribution to travel costs between -the training-site and home university. The Fellowships offer a unique opportunity to work with an international group of female and male researchers at the Centre of Electrochemical and Materials Processing Centre at Newcastle upon Tyne. The research into electrochemical systems at Newcastle upon Tyne University is an interdisciplinary effort between engineering and physical sciences with a major focus in the development of technologies for energy generation and environmental applications. This research is carried out through collaboration between staff in the Departments of Chemistry and Chemical Engineering. Our research encourages active collaboration between scientists, engineers and industrialists to develop innovative technologies. The research training includes electrochemical energy generation, fuel cells, intensified electrochemical and membrane reactors, advanced electrochemical separations, advanced electrolytes and materials for synthesis and innovative environmental electrochemistry and engineering. The site provides, through advanced courses, tuition in research methodologies, research management, and sustainability and in technical subjects such as electroch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The world's first purpose-built professional all-terrain passenger Vehicle' under Horizon 2020.

assistant: **Concept**

Tour operators and rescue services, operating in difficult conditions worldwide, need efficient passenger vehicles for their operations. However, today, no purpose-built on/off-road passenger vehicle is available that provides a combination of high performance, energy efficiency, passenger comfort and cost optimization. Current vehicles used for 7-21 passenger transportation and rescue in difficult, off-road conditions are highly-modified vans, SUVs and lorries. Modifying these vehicles with the necessary large tyres, extra fuel tanks, gear boxes and suspension systems is a time-consuming, costly and specialist task, and even the best of these modifications have significant drawbacks. We are Jakar, an all-terrain passenger vehicle manufacturer based in Iceland and our objective is to combine four decades of unique local knowledge into a pioneering modular vehicle solution. After years of close collaboration with tour operators and rescue teams, we have systematically identified and eradicated the design flaws of modified vehicles. Our new vehicle concept, Ísar, will be the world’s first purpose-built, EU-regulation-compliant, multi-passenger, high-performance vehicle for all terrain. We estimate the total global market opportunity for these vehicles is 10,000 units per year for use in tourism, Search and Rescue (SAR), and utilities.Ísar is a purpose-built vehicle that is made-to-order in modular sizes to carry up to 21 passengers. It will reduce operator seat-mile cost by up to 40%, yet is uniquely designed to deliver world-leading passenger comfort in any condition. Operators worldwide will have a purpose-made alternative to costly, compromised modifications. We already have 30 companies interested in purchasing our vehicle, and by 2025 we expect to have sold 102 Ísar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nature Based Solutions for Soil Management' (NBSoil) under Horizon Europe.

assistant: **Objectives**

NBSOIL (Nature Based Solutions for Soil Management) is a four-year project coordinated by the Institute of Soil Science and Plant Cultivation (PL). Its overall objective is to design an attractive blended learning programme to enable soil advisors to implement a holistic vision of soil health through Nature Based Solutions (NBS) and collaborate effectively across different temporal and spatial scales.NBSOIL will focus on 6 multifunctional NBS categories to develop a holistic approach to land management and soil health fully in line with the IUCN Global Standard for NBS (IUCN, 2020): organic fertilisers from locally available biowastes, cover crops, paludiculture, forest diversification, bioremediation, and blue - green infrastructure in urban and periurban areas. NBSOIL builds on previous research results and available Open Source technology to deliver the following NBSOIL thematic packs: Knowledge base, Academy, Soil Health assessment, monitoring and mapping resources, Policy Navigator, and Marketplace. Approximately 300 participants from 8 countries (PL, AT, CH, UK, FR, NL, IT, ES) are expected to complete the full 2 years training offered in 6 languages (English, Polish, German, Dutch, French, Italian, Spanish). The 2 years training programme will provide an immersive, interactive, flexible learning experience, through  an introductory Massive Open Online Course  (MOOC) followed by four advanced modules on 1. Soil and NBS, 2. Living Labs facilitation, 3. Digital tools for Soil Health monitoring and 4.Improving soil related decision making in business and policy, and a Final Project. The NBSOIL consortium will deliver Impact and contribute decisively to achieve the Soil Health Mission by mainstreaming NBS knowledge and advice for soil management, providing Soil Health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synthesis and biological Evaluation of G4-inducing Telomerase Inhibitors' (TELOMIN) under Sixth Framework.

assistant: **Objectives**

Telemetries are essential in maintaining the stability of chromosome ends and are synthesized by a specialized enzyme named telemetries. Telemetries are not expressed in most somatic cells but are over expressed in a large number of tumours and are involved with cell immortalisation and tumorigenesis processes. This differential expression was the initial rationale for the evaluation of telemetries inhibitors as potential anticancer drugs. The peculiar structure of telemetries, composed of Guanine repeats, allows forming an unusual DNA conformation based on a Guanine-quadruple (G-quadruple). In vitro, G-quadruple DNA inhibits telemetries activity, which has recently stimulated the search for legends that stabilize telemetric DNA under its G- quadruple conformation, as a new strategy to impair telemetries function in cancer cells. We have developed monomer MMQ and dimerism macro cyclic BOQ quinacridine (dibenzophenanthroline) derivatives that are strong G-quadruple interactive legends and potent telemetries inhibitors. The first objective of the research project is the improvement of the binding selectivity of the MMQ series. This will be achieved by the synthesis of polyamide- trisubstituted MMQ conjugates. This new generation of legend is hoped to achieve specific recognition of quadruple DNA in combining two binding modes, namely G-quartet stacking and anchorage in three grooves. The second objective of the research project is the evaluation of the potential of the BOQ macro cycles as selective G4 binders. This will be conducted through biophysical and biochemical studies of interactions of the BOQ series with various oligonucleotides forming quadruple. In addition, fluorescent derivatives of BOQ will be prepared in order to use them as quadruple-DNA probes both in vi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Exploring the structure and function of NUDT5 in de novo purine synthesis'.

assistant: **Concept**

Proliferation of tumour cells requires continuous DNA synthesis and energy supply. Purine nucleotides are essential building blocks for DNA. Recent research has highlighted the role of NUDIX hydrolase 5 (NUDT5) catalytic activity in nuclear ATP metabolism in breast cancer. Notably, NUDT5 has also been suggested as a more general prognostic marker for various cancers, and NUDT5 depletion leads to suppression of tumour cell proliferation in a variety of model systems. Strikingly, the host lab has recently discovered that NUDT5 possesses an unexpected non-enzymatic, likely scaffolding role in de novo purine synthesis. This observation is unprecedented for a catalytically active member of the NUDIX family. In this project, I aim to dissect the molecular mechanism and reveal the structural basis of NUDT5-regulated purine metabolism by combining Affinity Purification Mass Spectrometry (AP-MS) proteomics and metabolomics with X-ray crystallography and cryogenic Electron Microscopy (cryo-EM) with three main goals:(1)Unravel the molecular mechanism and role of NUDT5 in purine synthesis using a comparative metabolomics and proteomics approach using CRISPR knock out (KO) cell lines, small molecule inhibitors and degraders of NUDT5 in relevant cell line models.(2)Identify and define the NUDT5 interactome via AP-MS, and validate candidate NUDT5 interactors in biophysical and functional assays using purified proteins and cellular models.(3)Explore NUDT5 protein complexes using X-ray crystallography and cryo-EM to dissect the molecular interaction between NUDT5 and complex partners for regulation of purine synthesis.This work will offer novel fundamental insights into the molecular mechanism of NUDT5-mediated purine metabolism, and the scaffolding role of this enzyme to provide new pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Gene Therapy to restore lymphatic flow lymphedema' (TheraLymph).

assistant: **Innovation**

Lymphedema is a disabling condition induced by the accumulation of fluid and fat in the arm or in the leg. It is an untreatable disease that affects 4 millions people in Europe and more than 120 millions people worldwide. It is handicapping, painful and impacts substantially the quality of life. In western countries, lymphedema is generally a consequence of cancer treatments i.e. ten to fifteen percent of women will develop lymphedema after breast cancer. The main objective of Theralymph will be to establish a non-integrative gene therapy for this unmet medical need.The theralymph translational research program brings together bench scientists from 5 European countries and physicians from the hosted Rangueil hospital in which the PI institute is located to perform a Phase I/II trial focusing on women who developed lymphedema after breast cancer.Based on decades of disappointing results of monotherapy-gene delivery in cardiovascular diseases, our approach will be based on multiple gene therapy targeting both superficial lymphatic endothelium and deeper lymphatic collectors. We will identify molecules that possess a synergistic effect with the established lymphangiogenic factor VEGFC.Theralymph project will determine risk factors for lymphedema and cartography the lymphatic network in the pathology. It will decipher whether lymphatic intrinsic molecules or microenvironmental peptides or lipids are modified in the lymphedematous arm to promote the lymphatic dysfunction. Theralymph will validate the best molecule combination that restores the lymphatic drainage in in preclinical lymphedema models before human study. The Phase I/II gene therapy clinical trial will be performed in the vascular medicine department of Toulouse’s hospital, where the PI laboratory is located. Thi