RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Treatment of geosphere retention phenomena in safety assessments' under Fifth Framework.

assistant: **Concept**

In RETROCK it will be examined, how the retention processes should be recognised in the safety assessment (SA) models for deep geological repositories in saturated hard fractured rock.The project will judge in-depth the scientific basis of the available concepts, their applicability for simplified SA models, and to seek for the proper measuring approaches and data abstraction schemes (data up-scaling") for the utilisation of the experimental data. The present situation will first be mapped in the participating and selected other organisations.The practises will be studied by the experts of RETROCK and by selected external attendees to be invited in a Workshop in the midterm of the project. Finally, the project will publish a technical report with the synthesis on the retention processes and recommendations for the treatment of retention in SA models.The overall objective of the project is to develop a common basis for incorporating geosphere retention phenomena in safety assessments for deep geological repositories. The main focus will be in examining whether simplifications frequently adopted in safety assessments can be defended with more complex process models, experiments and other sources. The project concentrates on saturated fractured hard rocks, such as e.g. crystalline bedrock."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Establishing a mouse model for ICE Fever, a novel autoinflammatory syndrome associated with procaspase-1 mutations' to be submitted under Seventh Framework.

assistant: **Abstract**

In up to 80% of patients with symptoms of an autoinflammatory syndrome (periodic fever syndrome) a molecular diagnosis is currently not possible. Procaspase-1 (aka IL-1 converting enzyme, ICE) is a component of the CIAS1/NALP3 ‘inflammasome’ and plays critical roles in releasing the proinflammatory cytokine IL-1b. and regulating the NFkB-activating RIP-2 pathway. Sequencing of the procaspase-1 coding region from 200 patients with undiagnosed autoinflammatory syndromes revealed mutations in 8 patients, 7 of whom were heterozygous. The autoinflammatory syndrome associated with these mutations has tentatively been termed ‘ICE Fever’. X-ray crystallography and functional studies revealed that the resulting amino acid changes destabilize interactions within the interface of the mature caspase-1 tetramer and thus reduce proteolytic activity and IL-1b release. One consequence is an overactivity of the pro-inflammatory RIP-2 pathway due to diminished proteolytic inactivation of RIP-2 by caspase-1, potentially leading to autoinflammation. We propose to establish a mouse model for ‘ICE Fever’ by generating transgenic mice in which a single amino acid substitution in the active center has abolished the proteolytic activity of procaspase-1. For transgenesis, a novel ‘switch dual color’ vector will be used that allows to reproduce the wild type, heterozygous and homozygous states. Mice will be monitored in detail for the development of signs, symptoms and laboratory abnormalities suggestive of autoinflammation. Monosodium urate crystals, which are known to activate the NALP3 inflammasome, and the murine air pouch model of inflammation will be used to test for a possible exaggerated innate immune response. This will be the first mouse model for an inflammasome-associated autoinflamma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart Photovoltaic Façades for Self-Powered Buildings' in the context of a Horizon 2020 call.

assistant: **Objectives**

Buildings are responsible for 40% of energy consumption and 36 % of CO2 emissions and are an important field of action in the EU. Europe counts with a vast potential volume of 600000 non-residential buildings and more than 70% of the global photovoltaic market, forecasted to reach more than 2.05 billion € annually. PowerBrise comes as a smart solution both to significantly improve the energy self-consumption of large non-residential buildings and to increase their energy efficiency. Synthesis s.r.l.  goes a step further in the current state of the art by developing an novel photovoltaic solution for building Façades which integrates for the first time the benefits of  : (1) Brise soleil (or louver system), (2) Photovoltaic power and (3) Building Automation Systems (BAS).  PowerBrise uses sun radiation to generate power but at the same time lets in some sun light through the semi-transparent cells.Brise soleil by its own increases the comfort inside the building and reduces up to 25% its energy consumption; the integration of photovoltaic cells inside the glass of brise soleil and the smart motorization to automatically follow the sun direction, makes PowerBrise is able to save up 40% of the building energy costs, supplying by means of renewable energy, up to 25% of the energy consumed by the building. We expect that the deployment of PowerBrise in the EU and international markets will allow Synthesis for the exploitation of a business opportunity in new and retrofit installations that will bring cumulative revenues of 30 M€ by 2025, with a ROI of 4.7 and the creation of 37 direct jobs by 2025. This Phase 1 will allow us to ensure that PowerBrise is feasible from a technical and economic point of view, and that its implementation will be a commercial success
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Valorization trajectory of a 3D particle image velocimetry instrument'.

assistant: **Innovation**

Actual implementation of impactful applications for microfluidic devices in a commercial setting has been surprisingly limited so far. The cause can be to a great extent attributed to the main feature of microfluidic devices: their small dimensions. While miniaturized structures are essential in generating key functionalities, they are also ideal nucleation and anchor sites for solid material present in the liquid that flows through the channels, a phenomenon called fouling. This subsequently results in a reduced or loss of functionality and eventually plugging of the entire flow system. The solution to avoiding fouling is measuring the flow in microfluidic devices in 3D, by particle image velocimetry (PIV), either when designing or using them. However, achieving 3D imaging of flows is currently an extremely difficult task due to the amount of work, high costs and lengthy timelines required. Our value proposition in the ERC Proof of Concept project ‘3D-PIV’ is a table-top device able to efficiently analyse the velocimetry of particles in 3D, offering an unprecedented level of detail of the fluid motion through micron-sized channels/inlets/outlets, opening new possibilities in microfluidics design and validation with significant impact on multiple applications.  One of the killer applications we envision, and our focus in this ERC Proof of Concept project, is in the pharmaceutical and chemical industries, for the manufacturing of drugs or chemical components, to enable, adjust or improve their separation. In this project we will focus on building a strong business case for our 3D-PIV technology through prototyping, optimizing software, market analysis and business development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'WESTinnoMAR 2019'.

assistant: **Objectives**

The proposed project addresses the action for “Establishing services “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network” to improve the innovation management capacity of SMEs. The activities foreseen under this proposal is to give Activity 4 of EEN services to SMEs. 10 full enhancing SMEs’ innovation management capacity service packages will be offered to SME’s till the end of 2019 and every service package is foreseen as 7 days in the proposal. Additionally, 14 day KAM serviceswill be offered for successful beneficiaries of SME instrument Phase 1.


**Keywords:** innovation, SME, research&development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The creation of an integrated resource of protein domains and functional sites and its application to accelerate protein functional analysis'.

assistant: **Innovation**

An avalanche of data has been gathered by the various genome mapping and sequencing projects. This data combined with the biological information in databases has an inestimable potential value. The realization of that potential is heavily dependent on investments in the development of tools to make use of the underlying data in databases and to make this knowledge available to the scientific community. Protein sequence databases form a key computational resource for modern molecular biology. Searches against such a database frequently allow transfer of important functional information to a new sequence. However, transferring information from pairwise hits to other sequences is prone to error, particularly when this must be done on a large scale, for instance when annotating predicted genes from genome projects at the genome centres or when annotating sequences for inclusion in databases like SWISS-PROT + TREMBL. In recognition of these limitations, it is now essential to extend search strategies to include a range of secondary" databases when analysing novel protein sequences. Databases on functional sites and domains like PROSITE, PRINTS, PFAM, PRODOM, BLOCKS, etc., have become vital resources for identifying distant relationships in novel sequences, and hence for predicting protein function and structure. Unfortunately, these secondary databases do not share the same formats and nomenclature, which makes the use of all of them in an automated way difficult. In response to this the partners in this proposal (EBI, University of Geneva, ISREC, UCL, Sanger Centre, INRIA, CNRS/INRA, Compugen, LION, Pfizer and University of Bergen) want to address these problems by establishing an Integrated resource of Protein domains and functional sites (InterPro), and to apply this reso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a novel hiPSCs-derived Vascularized-Epicardial-Adipose-Tissue-on-Chip model to investigate cellular crosstalk in healthy and stressed states' (VEAT-ChiP) under Horizon Europe.

assistant: **Objectives**

Obesity-associated metabolic and cardiovascular diseases (CVDs) are serious public health concerns. A fat depot surrounding the heart, known as epicardial adipose tissue (EAT), is likely contributing to the pathologic conditions leading to CVDs. But it might also play a protective role during ischaemic events highlighting a complex role of EAT in heart homeostasis and disease. Some studies report post-menopausal women having an increased EAT suggesting that changes in levels of of sex hormones affect EAT and may cause sex-specific contributions to metabolic diseases. Though EAT covers nearly 80% of a human heart, it is virtually absent in rodents. Given the underexplored role of EAT in the pathology of CVDs, and the lack of animal models, human in vitro cardiovascular EAT model is necessary. VEAT-chip proposes to develop the first human induced pluripotent stem cells (hiPSCs) derived, fully autologous, vascularized EAT-on-chip model. The project will start with establishing a novel protocol to obtain epicardial adipocytes. Then, those cells will be integrated into hiPSCs derived cardiac-specific vessels-on-chip to generate a vascularized EAT-on-chip. Given an undetermined role of sex hormones for EAT function and an unclear balance of protective and toxic effects of EAT in pathological settings, vEAT-chip will explore hormone- induced changes in function of EAT during homeostasis and stressed conditions. In a final aim of the project, addition of cardiomyocytes (CMs) to the system will result in a model resembling a portion of the heart wall. By combining novel hiPSCs differentiation protocols, organ-on-a-chip technologies, advanced microscopy techniques, and global transcriptome and secretome analysis, the VEAT-chip project will reveal EAT-associated factors affecting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimized Diagnostics for Improved Treatment Stratification in Invasive Fungal Diseases' (FUNGITECT) under Seventh Framework.

assistant: **Objectives**

Invasive fungal disease (IFD) is a leading cause of morbidity and mortality in the growing number of immunocompromised individuals, including particularly cancer patients, and bone-marrow or organ transplant recipients. The majority of IFD events are still caused by Candida and Aspergillus species, but there is an increasing incidence of resistant or previously uncommon moulds, yeasts and Zygomycetes. Timely pathogen detection is a prerequisite for effective therapy in patients with IFD.FUNGITECT will focus on this medical priority and develop, validate and market a specific set of novel molecular diagnostic tests for IFD targeting fungal DNA-, RNA- and protein motifs, as well as the enzymatic activity of fungal pathogens. Additionally, FUNGITECT will provide a unique opportunity to establish and implement highly effective diagnostic assays supported by Next-Generation Sequencing and a bioinformatics service platform, facilitating optimized treatment strategies adapted to individual patient requirements with the following paramount aims: i) to provide the diagnostic basis for stratified and timely administration of the most appropriate antifungal therapy permitting improved management of patients with IFD, ii) to decrease the rate of overtreatment and the ensuing adverse side effects including fungal resistance, and iii) to help reduce the enormous healthcare costs for clinical antifungal therapy. The consortium includes leading academic research institutions, SMEs and Industry already successfully positioned in the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reconciling Classical and Modern (Deep) Machine Learning for Real-World Applications', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Despite the undeniable success of machine learning in addressing a wide variety of technological and scientific challenges, the current trend of training predictive models with an evergrowing number of parameters from an evergrowing amount of data is not sustainable. These huge models, often engineered by large corporations benefiting from huge computational resources, typically require learning a billion or more of parameters. They have proven to be very effective in solving prediction tasks in computer vision, natural language processing, and computational biology, for example, but they mostly remain black boxes that are hard to interpret, computationally demanding, and not robust to small data perturbations.With a strong emphasis on visual modeling, the grand challenge of APHELEIA is to develop a new generation of machine learning models that are more robust, interpretable, and efficient, and do not require massive amounts of data to produce accurate predictions. To achieve this objective, we will foster new interactions between classical signal processing, statistics, optimization, and modern deep learning. Our goal is to reduce the need for massive data by enabling scientists and engineers to design trainable machine learning models that directly encode a priori knowledge of the task semantics and data formation process, while automatically prefering simple and stable solutions over complex ones. These models will be built on solid theoretical foundations with convergence and robustness guarantees, which are important to make real-life trustworthy predictions in the wild. We will implement these ideas in an open-source software toolbox readily applicable to visual recognition and inverse imaging problems, which will also handle other modalities. This will stimulate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INTERACTIVE INFORMATION SYSTEM FOR HEALTH/SOCIAL CARE' (INFOCARE).

assistant: **Innovation**

INFOCARE will examine how to offer European citizens home or public remote access to information about local health and welfare provision. It is intended that they should take full advantage of existing or nascent telecommunications services regularly monitored for optimal user satisfaction. Expected project outcomes include mechanisms for service costs analysis, customer and user quality evaluation, and the implementation of demonstrated pilot applications to achieve them. Citizen information centres for personalised support are intended as a special feature.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Computer Experiments for Concurrent Engineering' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The introduction of Concurrent Enginnering has led not only to reduced time to market but also to an integrated approach to product and process development This last aspect has a strong potential for achieving more performant design solutions through an optimization process that takes into account all product relevant aspects. However. presently, this possibility is not fully exploited owing to the lack of tools that allow to tackle, at the same time, multiple design aspects leading to globally optimal solutions. The main objective of this project is the development of a general purpose tool and methodology that allows to achieve multiobjective optimization through the use of numerical simulation codes. The key idea of the project is to design, implement and test a system which replaces two or more simulation codes (simulators) by FAST EMULATORS (mathematical functions) which mimic behaviour of the simulators but run hundreds or thousands of times faster, and to adjoin to these a suitably designed MULTI OBJECTIVE OPTIMISER. The emulators will be based on a methodology based on the Design and Analysis of Computer Experiments which has already proved highly successful in the electronic field and preliminary studies show that this can be ported to other domains. The main components are:  Design and Analysis of computer experiments for fitting the emulators to the simulators  Multi objective optimiser using the latest algorithms, including global optimisation  Graphics and analysis module for interface with the designer  Connectors to cope with diverse input/output and data structures for different simulators. It is expected that design lead times in a multiobjective environment will be reduced by up to 20%. The project will be tested both during design and validation on re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integration of sar and optical products for crop management' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Earth observation has the potential to bring about innovation in European agriculture, allowing improved efficiency and reducing the environmental impacts of intensive farming. In preparation for satellite-based services, European capabilities to retrieve of biophysical parameters from hyper spectral optical data are established, but cloud cover will hinder service provision in many regions. Multi frequency, polar metric SAR data have the potential to provide valuable crop information such as biomass, which could provide substitute and supplementary products. SAR and super spectral data will be co-acquired over two growing seasons in northern and southern Europe. Isotropy will advance SAR retrieval techniques to a stage where SAR and optical products can be brought together within integrated services based on planned satellite missions.