RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hybrid hydrogen - carbon dioxide separation systems' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The main goal of this project is the development of a hybrid membrane/ Pressure Swing Adsorption (PSA) H2/CO2 separation process, which will be a part of a fossil fuel de-carbonization process used for the pre-combustion CO2 capture. Methane steam reformin g is currently the major route for hydrogen production and will be employed as a model case. High purity hydrogen (99.99+%) is usually recovered from the reformate by using a PSA process. A typical PSA waste gas stream (CO2~55%, H2~35%, CH4 & CO~ 15%) is not usually recycled since it has to be recompressed to the PSA feed pressure for recovering only a small fraction of the recycled hydrogen. Furthermore, it cannot be used for CO2 sequestration since it contains significant amounts of H2 and CH4. A hybr id process is expected to combine the high throughput and H2 product purity of a PSA process with the lower operating costs of a membrane process. It is expected to enhance the overall H2 recovery and provide an H2-free CO2 stream ready for capture and seq uestration. To achieve this goal in the proposed R&D project, the following scientific tasks have been identified: *Generation of transport and adsorption data for H2/CO2 multicomponent mixtures (CH4, H2O, CO) for well characterized membrane and sorben t materials *Development and improvement of membrane and PSA separation models *Design and optimization of membrane, PSA and hybrid separation systems using the improved models developed *Component design for the manufacture of a lab-scale hybrid separatio n system prototype *Assessment of the hybrid separation process sustainability and impact on the environment based on a life cycle analysis approach The following possible innovations are foreseen as an outcome of this project: *H2 recovery improvement *Si mplificati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Photon-recycling for high-efficiency energy harvesting in GaAs photovoltaic devices on silicon' to be submitted under Horizon 2020.

assistant: **Abstract**

The Internet of Things promises billions of connected sensors and devices measuring and reporting information about the world around us. Due to the limited lifetime of batteries, this vision will not be realised without energy harvesting solutions providing power autonomy to sensors, a topic specifically prioritised in the 2016-2017 Work programme of Horizon 2020  (page 100). This project aims to develop and demonstrate high-efficiency and low-cost GaAs photovoltaic energy harvesters as power sources for wireless sensors, and equip the fellow with the entrepreneurial competencies required to commercialise the results. Prof. Tonio Buonassisi’s photovoltaic research lab at MIT (PVLab) is a global leader in optoelectronic modelling and testing of novel photovoltaic devices, and will train the candidate to determine the technical and economical viability of this new technology. The growth of these novel devices will be carried out with Mr. Brian Corbett in the III-V materials and devices group at the the Tyndall National Institute, Ireland. During the outgoing phase, as well as training in technical competencies, one-day a week will be dedicated to attending MIT’s Translational Fellows Programme, a specialist course for entrepreneurially-minded postdocs, teaching venture creation in-line with the candidate’s career goal to be an EU leader in science-based entrepreneurship in the clean energy sector. On return to the EU, a secondment at IQE plc., a III-V foundry, will allow the economic aspects of producing these devices in industry to be explored.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'From instructions to actions: characterizing the spatiotemporal neural signatures of instructions following.'.

assistant: **Objectives**

From air traffic control to large surgery teams, some of the most advanced human collaborative achievements largely rely on our ability to successfully give and follow instructions. Given the combination of novelty, speed, complexity and efficiency, significant effort has been devoted to characterize the mechanisms underlying this ability. However, how the human brain rapidly (i.e. in a matter of seconds) transforms the content of instructions into actions is still poorly understood. This project aims at providing a fundamental description of this transformation by combining recently developed behavioral paradigms and cutting edge methodological and analytical tools. This combination is expected to result in a significant step forward in the understanding of instructions following, compared to the state-of-the-art.This project is especially timely given its relevance to ongoing debates in cognitive neuroscience regarding the structure of cognitive control and working memory systems. InstrAct will also be highly relevant to other disciplines such as robotics and artificial intelligence, which could benefit from the outcomes of this project to implement human-like, complex collaborative artificial systems, a crucial milestone in these fields.The success of this proposal relies on the combination of my expertise on multivariate analysis of neuroimaging data with the strong theoretical guidance offered by Dr. Brass’ team at the Faculty of Psychology and Educational Sciences, Ghent University, a critical hub for cognitive control and instructions following in particular. The expected outcome of this project will, first, enhance the role of Ghent University and Europe as a hub for excellent research on instruction following. Second, it will be a boost in crucial aspects of my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'X-RAY LASERS, PHOTON SCIENCE, AND STRUCTURAL BIOLOGY' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Theory predicts that with an ultra-short and very bright coherent X-ray pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus, or a cell before the sample explodes and turns into a plasma. The over-sampled diffraction pattern permits phase retrieval and hence structure determination. The first free-electron lasers (FELs) capable to deliver ultra bright and very short X-ray pulses for such experiments have recently started operations. These are the most brilliant sources of X-rays to date, exceeding the peak brilliance of conventional synchrotrons by a factor of 10 billion. In the duration of a single flash, the beam focused to a micron-sized spot has the same power density as all the sunlight hitting the Earth, focused to a millimetre square. The interaction of an intense X-ray pulse with matter is profoundly different from that of an optical pulse. A necessary goal of the programme is to explore photon-material interactions in strong X-ray fields. Our aim in structural biology is to step beyond conventional damage limits and develop the science and technology required to enable high-resolution studies of single biological objects near the physical limits of imaging. Eligible targets include single virus particles, organelles, cells, nanocrystals, and isolated macromolecules. A particular aim of the planned work is to obtain high-resolution structures for giant viruses. The challenges engage an interdisciplinary approach, drawing upon structural sciences, biology, atomic and plasma physics, optics and mathematics. The potential for breakthrough science is great with impact not only in biology or physics but wherever dynamic structural information with high spatial and temporal resolution is valuable.  The overall relevance of the progra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exhaustion-resistant CAR-T cells for the treatment of solid tumours' (Exh-Res-CART), addressing dissemination and exploitation.

assistant: **Impact**

Adoptive transfer of T-cells collected from patient’s blood and engineered to express chimeric antigen receptors (CARs) has produced unprecedented clinical responses in patients with cancer. CAR-T cells targeting CD19 were recently approved by the US food and drug administration (FDA) and the European Commission (EC) for the treatment of leukemia and lymphoma, heralding a new era for cancer treatment. However, despite the stunning results of CAR-T cells in patients with hematologic malignancies, results with CAR-T cells in patients with solid tumors are far from expected. Although CAR-T cells are able to infiltrate solid tumors and exert antigen directed activity, observed responses in patients with solid tumors have been minor and transient. But what are the mechanisms behind the poor T-cell activity in solid tumors? Are CAR-T cells susceptible to dysfunction in a similar way as the endogenous tumor-specific T cells that fail to eliminate the tumors in treatment-naïve cancer patients? My central hypothesis is that CAR-T cells become exhausted in the tumor microenvironment mainly due to continuous antigen encounter, and that this process can be prevented or delayed. My general aim for this project is to enhance the persistence and function of CAR-T cells by overcoming T-cell dysfunction while promoting T-cell stemness. By using animal models and a combination of innovative technologies, including next-generation sequencing and genome editing I will: 1) elucidate the T-cell intrinsic mechanisms by which CAR-T cells become unresponsive to solid tumors, 2) design new approaches to enable infused T cells to overcome dysfunction and persist within the tumor microenvironment.


**Keywords:** Chimeric antigen receptors, solid tumors, T-cell dysfunction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Simulation of Transients in Hydraulic Machines' in the context of a Seventh Framework call.

assistant: **Objectives**

Because of the evolution of the electricity market in Europe hydraulic machines are operated in non conventional conditions. This leads to the apparition of strong transient flow phenomena that are not well understood. Conventional numerical simulation tools are not well adapted to capture these transient phenomena. It is proposed to use a novel approach based on the mesh-free technique Smoothed Particle Hydrodynamics to simulate these flows. This numerical method has recently proved its ability to overcome some major shortcomings of conventional CFD techniques. The method can also remarkably simulate fast-transient phenomena. The novelty of the approach is firstly that the SiTHyM projects aims at using the SPH method to simulate internal flows, secondly that a coupling of the SPH and Finite Volumes approaches will be achieved. The idea is to take profit of the ability of the FV method to model boundary layers efficiently and with a reasonnable cost, while the main part of the flow where convective phenomena are predominant is solved by the SPH method. As a consequence the method does not need any rotor-stator interface. It is expected that this feature will bring a major improvement to the study of rotor-stator interactions in transient phases. In order to implement the coupled method in an industrial CFD process, an efficient parallel implementation of the tool is required. The project will tackle a GPU implementation, as it is a very promising technology that has recently emerged in the HPC community. The numerical tool will then be applied to transient free surface flows in Pelton turbines and to transient internal flows in reversible pump turbines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Viruses and Epitranscriptomics: seeking novel targets for antiviral therapy' (EpiViral).

assistant: **Innovation**

The Universidade de Aveiro (UAVR) is widely recognized as one of the most innovative universities in Portugal. Its research activities are carried out by 20 research units (RU) covering diverse scientific areas. The Institute of Biomedicine (iBiMED-UAVR), one of UAVR’s most recent RU, is ranked among the top 5 research institutions in the biomedical field in Portugal. However, progress is mainly affected by low national funding availability and access to cutting-edge resources and infrastructures. This Twinning proposal (EpiViral) was set on the strategic vision of iBiMED-UAVR to boost the scientific excellence of its young researchers in the fields of virology and epitranscriptomics, which are underrepresented at the national level. To achieve this, EpiViral’s strategy relies in 5 main pillars: 1) Boost research excellence of iBiMED-UAVR in the fields of virology and epitranscriptomics, by implementing joint research projects; 2) Stimulate the innovation capacity of iBiMED-UAVR and contribute to new joint teams of  highly-skilled researchers; 3) Promote and enhance networking and international awareness of iBiMED-UAVR research and achieve broad societal impact for virology and epitranscriptomics research; 4) Promote the establishment of links with industry based on the experience and best practices of the two leading partners; and 5) Create an advanced and sustainable virology and epitranscriptomics research network for further cooperation. We believe EpiViral Twinning project will allow iBiMED-UAVR researchers to thrive in the cutting-edge field of epitranscriptome modulation in the context of viral infections, by potentiating a network which has the ideal expertise and know-how to achieve its objectives. EpiViral will thus assertively project iBiMED-UAVR as a Europea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Protein stabilization by chemistry: total synthesis of an MHC class I scaffold' under Seventh Framework.

assistant: **Concept**

Technologies for T cell visualisation and T cell depletion/enrichment are steadily making their way into the clinic and developments seem dictated by availability and reliability of the peptide-Major Histocompatibility Complex (pMHC) reagents used. A bottleneck has always been the laborious process of expression, refolding and purification of individual pMHCs. Recently, conditional MHC technology, pioneered in the host laboratory, solved this problem in part by enabling high-throughput loading of one MHC allele with a wide panel of peptide ligands. However, the rapid, parallel generation of a variety of MHC alleles is still a major hurdle. Therefore, proposed research aims at the total chemical synthesis of conditional MHC platforms, to make high-throughput generation of different MHC alleles reality. Recent advances in solid phase peptide synthesis (SPPS) have now enabled the generation of long polypeptides and even small proteins. This proposal aims to use SPPS rather than biological expression systems for total protein synthesis. The major advantage of using chemical techniques for protein synthesis is (1) that it allows the facile introduction of (non-natural) amino acids with functionalities that stabilise the protein by enhanced H-bonding, intrastrand crosslinking or intramolecular cross-linking (cyclisation) and that enable immobilisation or conjugation, (2) that protein yields are higher, and (3) that it simplifies the controlled generation of GMP grade proteins for biomedical use.The outcomes of this project will benefit the development of adoptive T cell therapy and will enable epitope scans through entire genomes of emerging pathogens (e.g. pandemic H1N1 Influenza), thus contributing to vaccine development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Initiative to Enable Validation for Highly Automated Safe and Secure Systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

ENABLE-S3 will pave the way for accelerated application of highly automated and autonomous systems in the mobility domains automotive, aerospace, rail and maritime as well as in the health care domain. Virtual testing, verification and coverage-oriented test selection methods will enable validation with reasonable efforts. The resulting validation framework will ensure Europeans Industry competitiveness in the global race of automated systems with an expected market potential of 60B€ in 2025.Project results will be used to propose standardized validation procedures for highly automated systems (ACPS). The technical objectives addressed are: 1. Provision of a test and validation framework that proves the functionality, safety and security of ACPS with at least 50% less test effort than required in classical testing. 2. Promotion of a new technique for testing of automated systems with physical sensor signal stimuli generators, which will be demonstrated for at least 3 physical stimuli generators. 3. Raising significantly the level of dependability of automated systems due to provision of a holistic test and validation platform and systematic coverage measures, which will reduce the probability of malfunction behavior of automated systems to 10E-9/h. 4. Provision of a validation environment for rapid re-qualification, which will allow reuse of validation scenarios in at least 3 development stages. 5. Establish open standards to speed up the adoption of the new validation tools and methods for ACPS. 6. Enabling safe, secure and functional ACPS across domains. 7. Creation of an eco-system for the validation and verification of automated systems in the European industry. ENABLE-S3 is strongly industry-driven. Realistic and relevant industrial use-cases from smart mobility an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How insulin resistance in the dorsal vagal complex affects glucose metabolism and feeding behaviour' in the context of a Horizon 2020 call.

assistant: **Objectives**

The central nervous system (CNS) integrates peripheral hormonal signals to regulate glucose homeostasis and feeding behavior. Obesity can cause the development of insulin resistance in the brain and completely disrupt the regulative functions of the CNS. Restoring the brain’s ability to modulate metabolic functions could be very important to prevent the negative outcomes of obesity and diabetes. The Dorsal Vagal Complex (DVC) in the brainstem senses insulin to regulate glucose metabolism and feeding behavior in rodents. Three days of high fat diet feeding (HFD) is sufficient to completely disrupt the insulin response, thus causing an increase in blood glucose levels and overnutrition. I propose to understand the molecular events that trigger the development of insulin resistance in the DVC and understand the neuronal networks involved in the regulation  glucose metabolism and feeding behavior in the DVC. I will use a combination of in vitro molecular approaches and in vivo physiological readouts to shed light on the physiological functions of this area of the brain. Identification of novel target molecules that are involved in the development of insulin resistance may also provide the basis for the development of new pharmacological approaches to counteract the development of obesity and diabetes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Security Research Conference 2009' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The objective of this SSA-project is to arrange the 4:th annual European Security Research Conference (SRC-09).The annual European Security Research Conference has, since its start, been a major component in the evolution of civil European security research. We thus intend to welcome the research constituency to the fourth conference which will be held in Stockholm on the 29:th to 30:th of September 2009. This event will be organized by the Swedish Governmental Agency for Innovation systems under the Swedish Presidency of the European Union in the fall of 2009.The event is expected to bring together aproximately 1000-1,200 representatives from research, industry, European institutions, public authorities and other stake-holders with interests for the security of Europe’s Citizens. Our intention is to make this the event of the year for Europe’s researchers, innovators, engineers, policy and business decision-makers whom are interested in  influencing the shaping of policies and research options for Europe’s future within security.