RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced direct biogas fuel processor for robust and cost-effective decentralised hydrogen production', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

BioROBURplus builds upon the closing FCH JU BioROBUR project (direct biogas oxidative steam reformer) to develop an entire pre-commercial fuel processor delivering 50 Nm3/h (i.e. 107 kg/d) of 99.9% hydrogen from different biogas types (landfill gas, anaerobic digestion of organic wastes, anaerobic digestion of wastewater-treatment sludges) in a cost-effective manner.The energy efficiency of biogas conversion into H2 will exceed 80% on a HHV basis, due to the following main innovations:1) increased internal heat recovery enabling minimisation of air feed to the reformer based on structured cellular ceramicscoated with stable and easily recyclable noble metal catalysts with enhanced coking resistance; 2) a tailored pressure-temperature-swing adsorption (PTSA) capable of exploiting both pressure and low T heat recovery from the processor todrive H2 separation from CO2 and N2; 3) a recuperative burner based on cellular ceramics capable of exploiting the lowenthalpy PTSA-off-gas to provide the heat needed at points 1 and 2 above. The complementary innovations already developed in BioROBUR (advanced modulating air-steam feed control system for coke growth control; catalytic trap hosting WGS functionality and allowing decomposition of incomplete reforming products; etc.) will allow to fully achieve the project objectives within the stringent budget and time constraints set by the call.Prof. Debora Fino, the coordinator of the former BioROBUR project, will manage, in an industrially-oriented perspective, the work of 11 partners with complementary expertise: 3 universities (POLITO, KIT, SUPSI), 3 research centres (IRCE, CPERI, DBI), 3 SMEs (ENGICER, HST, MET) and 2 large companies (ACEA, JM) from 7 different European Countries.A final test campaign is foreseen at TRL 6 to prove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of Novel Inspection Systems for Railway Wheelsets' in the context of a Seventh Framework call.

assistant: **Objectives**

The contribution of the rail industry to the economic growth of the EU member states is widely acknowledged. Very recently, the European rail industry has started showing signs of recovery after a long period of steady decline. The technological advances in train design during the last few decades have led to the manufacturing of faster and more comfortable trains making rail transport a more attractive option for passengers in comparison to other means of transportation. The need for the society to employ greener transportation policies is expected to further enhance the role of rail transport in the global economy. Today rail networks across Europe are getting busier with trains travelling at higher speeds, carrying more passengers and heavier axle loads than ever before. The combination of these factors has put considerable pressure on the existing infrastructure, leading to increased demands in inspection and maintenance of rail assets. The expenditure for inspection and maintenance has thus, grown steadily over the last few years without however being followed by a significant improvement of the industry’s safety records. A large proportion of all equipment related accidents in the rail industry is due to failed train wheels and axles. The continuous increase in train operating speeds means that catastrophic failure of a wheel or axle may result in very serious derailments, such as the one that took place in Eschede, Germany in 1998, causing loss of life, injuries, severe disruption in the operation of the network, damage to the tracks, unnecessary costs, and loss of confidence in rail transport by the general public. SAFERAIL seeks to minimise wheelset failures by developing and successfully implementing a novel on-line system for the inspection of wheels and axle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ductility and Fracture Toughness analysis of functionally graded materials.' in the context of a Horizon Europe call.

assistant: **Objectives**

In this project, we aim to build an intercontinental and inter-multidisciplinary research network to unravel what is referred to as a pending challenge of Continuum Mechanics, Material Science, Aerospace Engineering and Civil Engineering: analysis and optimization and design of new functionally graded materials with unprecedented combinations of mechanical properties and functionalities, such as stiffness, strength, ductility, toughness, and formability, with minimal weight and cost. The rational solution to this problem is to adapt the local properties of different materials to fit specific requirements, by locating optimized compositions and architectures in appropriate regions, and generating multiple advantages within a single material to create improved global properties. The network is an international consortium composed by 10 research organizations, (4 European beneficiaries and 4 American, 1 Australian and 1 Brazilian associated partners) who will exchange and share skills and knowledge with the view to understand and optimize the ductile and toughness behavior of brittle  and ductile functionally graded materials. Breakthroughs in this field will allow functionally graded materials fabricated by additive manufacturing to replace traditional composites with sharp transition between dissimilar components commonly used in critical applications in construction of civil infrastructures and in aerospace, security and transportation industries, all sectors of crucial importance for the European economy and society, as stated in clusters (iii) Civil Security for Society, (iv) Digital, Industry and Space and (v) Climate, Energy and Mobility of Horizon Europe. The staff members who participate in the project will be exposed to new research environments and develop new s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Designer Condensates for Regulation of Catalytic Processes'.

assistant: **Innovation**

Living cells have evolved to provide subcellular microenvironments that accommodate and control specific (bio)catalytic processes. These compartments include membrane-bound and membraneless organelles, or biomolecular condensates. New breakthroughs in studying and characterizing cellular biomolecular condensates have facilitated researchers to design synthetic condensates that are formed by liquid-liquid phase separation of engineered proteins, polypeptides, peptides, or nucleic acids. Yet, a precise regulation of designed condensates properties and their utilization for nanobiotechnological applications remains a major challenge. I propose to utilize my expertise in peptide design to develop libraries of synthetic condensates with systematically tunable chemical composition using minimalistic LLPS-promoting peptide building blocks. I will analyze how the chemical composition of condensates affect their physical and material properties and harness this knowledge to regulate organic reactions and drug synthesis in engineered microenvironments and develop condensates with emergent collective catalytic capacity. The proposed research will elucidate how the chemical composition, physical, and material properties of designed condensates affect reaction rate, conversion, and condensate reactivity. The designed condensates will go beyond the state of the art of synthetic nano- and microreactors and provide the next generation of reaction regulation for sustainable drug synthesis in organic solvent-free, aqueous environment. These findings will pave the way to establish novel design principles for the fabrication of synthetic condensates from peptide building blocks with both ordered and disordered motifs, leading to precise controlling, and balancing of these motifs to regulat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Preventing Abuse of Children in the Context of AIDS  in sub-Saharan Africa'.

assistant: **Objectives**

To date, 12 million children have been orphaned by AIDS, and 70 million more live with AIDS-affected caregivers within sub-Saharan Africa. Our programme of research has demonstrated heightened levels of physical, sexual and emotional abuse amongst children in AIDS-affected families. Despite increasing calls for intervention studies addressing child abuse in the developing world (UN 2008; WHO 2010) no interventions or research have yet targeted this high-risk group of AIDS-affected children. This project will develop and test, using a randomised controlled trial design, an evidence-based intervention to prevent and reduce child abuse within AIDS-affected families in South Africa.The study takes an innovative approach, incorporating a tripartite collaborative process between scientists, policy-makers, and civil society, thus maximising cultural applicability and sustainability. The randomised controlled trial includes 1600 adult and child participants, with wait-list controls and 1-year post-test evaluation in a real-world setting. The research has the key aims of 1) Testing theoretical frameworks of causation and prevention of child abuse in the developing world; 2) Testing the efficacy of an intervention for reducing child abuse; (3) Examining potential intervention moderators and mediators; (4) Testing the feasibility of the intervention when implemented by community volunteers at a low cost; (5) Disseminating results within sub-Saharan Africa to inform policy and programming.This study capitalises on the PI’s position as a scientific advisor to Southern African governments and international NGOs, on the expertise of a senior advisory group of academics and policy-makers, and on an established research team. This research is of immediate necessity in promoting child de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular Basis of Tubulin Transport During Cilium Formation' to be submitted under Horizon 2020.

assistant: **Abstract**

Cilia are essential hair-like structures presented at the surface of eukaryotic cells that allow motility, fluid flow and complex inter- and intracellular signalling events. Nine pairs of microtubules organized in a cylindrical shape called axoneme form the backbone of cilia. The formation and maintenance of cilia is dependent on a multi-subunit protein complex termed the intraflagellar transport (IFT) complex that actively delivers axonemal building blocks such as tubulin from the base to the tip of growing cilia. Lack of cilia or its miss-construction leads to severe developmental diseases called ciliopathies. Despite its fundamental role in cilium biogenesis, the process of tubulin recruitment, loading and unloading by the IFT machinery remains poorly understood. In this proposal, I aim to elucidate the mechanism of tubulin loading onto IFT complexes by determining high-resolution structures of intraflagellar transport (IFT) complexes bound to tubulin. Details about the IFT-tubulin interaction interface will be obtained by a combination of biochemical techniques like site directed photo- and chemical crosslinking followed by mass-spectrometry analysis and the structural biology techniques X-ray crystallography and single particle cryo-electron microscopy (cryo-EM). Ultimately, this study will enrich our understanding of cilium biogenesis and homeostasis by providing the first insight at atomic resolution into cargo selection and loading onto IFT machinery.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Therapeutic modulation of thrombogenicity of the atherosclerotic plaque' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Coronary artery disease, the primary cause of death in the western world, is induced by an acute cessation of the blood flow due to the formation of an occluded thrombus or blood clotin or nearby an unstable atherosclerotic lesion. Whether or not thrombotic complications will ensue from plaque rupture is strongly dependent on the presence of procoagulant molecules within the plaque. Interference with their activity thus represents a promising approach to influence the initiation and progression of the disease. The general goal of the project is:- to inhibit expression and activity of procoagulant proteins by delivering specific enzymes and,- to modulate the activity of transcription factors regulating these proteins.Modulation will be effected by atherosclerotic plaque-directed adenoviral gene transfer, bone marrow transplantation from corresponding transgenics and administration of therapeutic inhibitors in an advanced mouse model of accelerated atherosclerosis. The effect on the plaque size and morphology as well as on its lipid content and thrombotic nature will be determined. We anticipate that the results will lead to new therapeutic entries for reducing the thrombogenicity of atherosclerotic plaques and thus preventing thrombotic complications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Entrepreneurial & Innovative Universities Acceleration Programme' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Higher Education Institutions (HEIs) can have a strong positive impact on regional and Europe-wide social and economic development through education, research and engagement. However, they require targeted, methodological and experienced support to enhance their capability to fully realise their potential.Accelerate_FutureHEI responds to the above-mentioned needs through the development and testing of acceleration services to support HEI institutional transformation involving:- A robust, comprehensive methodology that is designed to transform and impact not just the HEIs but also their regions. It does so by taking an evidence-based approach that identifies the needs of the individual HEIs whilst also benefitting from an efficient universal approach that enables them to learn from each other.- Underpinned by a change management process, the project offers an acceleration support system that builds on the status quo, develops a connected vision and set of activities described in a roadmap and is then executed in application projects supported with coaching, training and international exchange.- Consortium built for success and impact as the project and overall methodology for acceleration services is designed, led and monitored by proven, globally-recognised experts specialised in implementing acceleration services to effect change at HEIs through entrepreneurship, innovation and engagement.- The consortium offers the right setting for a pilot program to deliver a meaningful context-connected, practical outcomes for a committed and diversified set of 14 partners, uniting 2 established EIT HEI Initiative consortia, where impact would make a real difference in their regions.- Sustained impact will be achieved as HEIs will have developed strong internal understanding of sta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DNA-encoded REconfigurable and Active Matter' (DREAM) under Horizon Europe.

assistant: **Objectives**

Synthetic materials exist in a broad variety of sizes, shapes and compositions leading to an impressive breadth of useful functions but tend to be case-specific. Living matter, in contrast, has the remarkable capability to sense, evolve, transform and adapt. Here, we propose to develop new DNA-encoded dynamic principles and implement them as molecular codes to program similar life-like characteristics in a variety of synthetic soft materials, ranging from evolutive DNA nanomachines to genetically encoded active interfaces. Various DNA nanostructures (DNA origamis, single-stranded tiles, DNA nanogrids) will be produced by a new concept of isothermal and reconfigurable DNA self-assembly, leading to user-defined self-assembled structures capable to adapt and morphologically transform, autonomously or in response to a stimulus. Coupling proteins to these reconfigurable nanoscaffolds will allow us to reconstitute dynamic synthetic metabolic pathways, design programmable catalytic switch or develop a new principle of nanostructure discovery by evolution. Beside encoding structural dynamics, we will also incorporate gene-containing DNA in interface-rich materials (films, drops, emulsions) to program, at a genetic level for the first time, the active behaviour and dynamic functionality of these systems. In situ cell-free expression of interfacially active proteins, such as BslA and hydrophobins, will allow us to control the interfacial properties (surface tension, visco-elasticity), either uniformly or with controlled spatio-temporal patterns. This will result in original genetically encoded active behaviours such as genetic Marangoni effects, propulsion, genophoresis or autonomous genetic sorting. Additional functionality will be brought by co-expressing useful proteins (enzym
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Supramolecular nanostructured organic/inorganic hybrid systems' (NANOMATCH), addressing dissemination and exploitation.

assistant: **Impact**

NANOMATCH is an interdisciplinary and intersectorial research and training network in the emerging field of nanoscience and -technology. The project aims at the development of tailored photo- and electro-responsive organic/inorganic hybrid systems such as photovoltaic cells, LEDs, and electro-optic modulators, by combining the advantages of organic and inorganic materials. Widespread application of polymeric materials is mainly restricted by their limited chemical stability and lack of control of (inter-) molecular order. In our approach, these limitations are overcome by hierarchical organization of matter at different scales.A. Molecular control is attained by the 'oligomer approach', to tailor the molecules to specific applications such as 'stopcock' and anchor molecules, colour tuning, high PL and NLO efficiencies, as well as energy (ET), electron (eT) and proton transfer properties.B. Control at the nanoscale is achieved by the supra molecular concept of host-guest compounds, with active molecules encapsulated in (in-) organic hosts, to obtain chemical stability, intrinsic polarization, enhanced lasing-, PL-, NLO-, ET- and eTefficiencies, as well as energy funnelling.C. Control at the microscale is fulfilled by matching the nanostructured microscopic object s to the 'outside world', through self assembly, deposition on patterned surfaces, (non-) covalently binding via the 'stopcock principle', inkjet printing, and homogeneous dispersion in polymers.The control of order in this approach opens new possibilities in device technologies, but also deepens the understanding of elementary processes such as energy- and electron transfer in 3-dimensional molecular arrangements and at the organic/inorganic interface by full-control of the structural, electronic and optical pa