RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders' (COSYN) under Horizon 2020.

assistant: **Objectives**

COSYN integrates outstanding European academic and three large Pharma to exploit genomic findings for intellectual disability (ID), autism, and schizophrenia. We capitalise on comorbidity, from clinic to cells and synapses, and have access to large existing samples. We focus on rare genetic variants of strong effect in patients with clinical comorbidity. Our aims are: (1) Understand comorbidity by comparing symptom and syndrome overlap with novel neurobiological criteria; (2) Elucidate mechanisms of comorbidity using neurobiology for the major genomic clue of synaptic dysfunction to unravel the cellular mechanisms of comorbidity; (3) Generate novel neuronal cell models by using advanced technologies to make neurons from carefully selected patients, and use genome editing to create or correct genetic variants. Multiple advanced neuroscience platforms are in place to evaluate an extensive set of molecular and cellular parameters, and to identify alterations in synaptic biology characteristic of ID, autism, and schizophrenia. These cellular models will, with Pharma partners, be up-scaled to provide “industry-standard” cellular assays for compound screening; (4) Refine diagnostic tools, use novel genomic and cellular features to improve disease classification and discriminate specific patient subtypes; and (5) Case studies in precision medicine: with Pharma partners, identify patients with a genetic change whose consequences can be reproducibly ameliorated in vitro by an approved medication. Recommend to the patient and clinician a double-blinded, N-of-one crossover case study to evaluate the clinical utility of a medication precisely indicated for that person. COSYN is an integrated, state-of-art, bench-to-bedside programme focused on personalised therapeutics. COSYN is a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intelligent Energy Efficiency Advisor' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Small and medium enterprises (SMEs, i.e. small offices, restaurants, coffees, retailers, pharmacies, small hotels, etc) typically have electricity bills that can easily exceed 500€/month and high savings potential (above 20%). Nonetheless, theydo not have adequate solutions to promote energy efficiency, as current solutions are either: i) highly complex and costlyBuilding Energy Management Systems suited only for large buildings or ii) focused on the residential sector needs. Neitherof these solutions address the needs of the more than 20 million SMEs in EU-28.Leveraging on the infrastructure developed by Watt-IS focused on promoting energy efficiency by a Non-Intrusive LoadMonitoring algorithm and a user engagement platform that is currently in pre-commercialization stage, we intend to bring tothe market a low cost solution for SMEs, integrating real-time energy monitoring, and innovative automatic generation oftailored energy efficiency measures, intelligent control (lighting and HVAC) and suited for Demand Response (DR) programs– the Intelligent Energy Efficiency Advisor (iE2Advisor currently TRL 6).Although the end-users are SMEs, the main clients for iE2Advisor are Energy Service Companies (ESCOs) and EnergyUtilities that can implement the IE2Advisor in their SME clients, generating value throughout the whole value chain, to SMEs(lower energy bills), ESCOs (higher energy savings generated to their clients) to utilities (more flexible management ofenergy loads and reduction of churn rates).Our aim for Phase 1 of the SME Instrument is to validate our Business Model, Market Analysis and Pricing schemes, inorder to follow up with a Phase 2 proposal to engage around 10,000 SMEs (through ESCOs) and 315,000 (through Utilities)after 5 years, representing around 10.7 M€ in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Multifunction Future Laser Atmospheric Measurement Equipment'.

assistant: **Concept**

Objectives and content Major airports in Europe reach saturation traffic levels at peak times where the limiting factor is the need to impose aircraft separation distances in order to avoid hazard to following aircraft caused by the presence of wake vortices from preceding aircraft. A highly desirable alternative to building new airports or runways, with their attendant large environmental and financial costs, would be to reduce separations. This could be achieved without any reduction in safety standards if it were possible to reliably detect the presence of wake vortices from preceding aircraft. An airborne eye-safe LIDAR offers the means to do this with the required level of safety. In addition, an airborne remote sensing LIDAR Doppler anemometer offers the possibility of detecting other atmospheric hazards at long range of which the most well-known is windshear. The current CEC FLAME project has demonstrated the viability of a LIDAR wake vortex detection system, including its operational aspects. This includes the development and demonstration of the core technologies and techniques for wake vortex detection, particularly the laser and signal/image processing technologies. The MFLAME task objectives are: - To extend the multifunctions applications area of the MFLAME equipment to include, in addition to wake vortex detection, dry windshear predictive detection, and to assess the predictive detection capabilities in areas such as clear air turbulence, volcanic ash, gust alleviation, mountain rotors and dry hail. - To demonstrate wake vortex detection and windshear detection by means of a series of ground and flight tests of a 2 m LIDAR system and to evaluate the other available multifunction capabilities. - To improve the techniques and technologies for a future cost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Desorption Electrospray Ionization (DESI) coupled to a high resolution mass spectrometer: fundamental studies and improvements of analytical performance' (DESI) under Seventh Framework.

assistant: **Objectives**

The objective of this proposal is to improve analytical performance of Desorption Electrospray Ionization (DESI) coupled to a high resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR-MS) and gain more insight into the DESI mechanism and underlying processes. DESI is a novel ionization method, that combines features of electrospray ionization (ESI) with those of the family of desorption ionization (DI) methods. The DESI experiment allows molecules present on surfaces to be analyzed by mass spectrometry without requiring the sample to be introduced into the vacuum system of the mass spectrometer. DESI differentiates itself from other DI methods in mass spectrometry because the sample can be analyzed outside the mass spectrometer in an open laboratory environment. There is virtually no sample handling in DESI and no ionization matrix needs to be added to the sample; the sample is sprayed with charged microdroplets of solvent (e.g. water, methanol etc.), delivered by a simply modified electrospray emitter (electrosonic electrospray or ESSI).  DESI proved itself to be a useful tool in a very wide range of disciplines from traditional chemical and pharmaceutical process and quality control to more exotic applications including dactyloscopy and tissue imaging. Most of the interest in DESI inside mass spectrometry community is chiefly in the analytical applications area. There have only been handful reports focused on DESI theory and mechanism. Thus, the fundamental processes in DESI are not fully understood and despite many advantages DESI also suffers limitations, especially relatively poor Limit of Detection (LOD) compared to competing mass spectrometry techniques. The analytical figures of merit will play more significant role in the near future b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Investigating the structural basis of TREX function in mRNA export using cryo-electron microscopy and super-resolution fluorescence microscopy' (TREXSpliceosome) under Horizon 2020.

assistant: **Objectives**

Eukaryotic mRNA is transcribed, capped, spliced and poly-adenylated in the nucleus, but translated in the cytoplasm. Nuclear mRNA export is a key step in gene expression which is still poorly understood in mechanistic detail, but the multi-subunit transcription and export (TREX) complex plays a central role in the process. TREX bridges transcription, RNA processing and packaging to facilitate mRNA export licensing. Understanding TREX function is relevant to human health, as TREX protects against transcription-associated genome instability, is required for development, and has been linked to human disease, including several types of cancer. Despite its importance, many questions about TREX function remain, in particular, how is TREX recruited to mRNA and how is the export factor NXF1-NXT1 deposited on mature mRNA? Here, I propose to study the mechanistic basis of TREX recruitment and function using structural biology and imaging approaches. The host laboratory recently purified an endogenous multi-megadalton spliceosome–TREX complex, whose three-dimensional cryo-EM structure I aim to determine. This will reveal how TREX is recruited to maturing mRNA to read out and relay the presence of activating and repressive marks to, ultimately, decide whether or not to export the mRNA. In close collaboration with the Balzarotti lab (IMP), I will use super-resolution microscopy (MINFLUX) to visualize post-recruitment functions of TREX in situ and test models of how deposition of the mRNA export factor NXF1-NXT is linked to export competence. Taken together, the proposed work will significantly enhance our understanding of TREX as a chaperone of nuclear mRNA processing and export.


**Keywords:** mRNA export, splicing, cryo-EM, super-resolution microscopy, MINFLUX
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European  Natural  Airborne  Disaster  Information and Coordination System for Aviation' to be submitted under Horizon 2020.

assistant: **Abstract**

Aviation is one of the most critical infrastructures of the 21st century. Even comparably short interruptions can cause economic damage summing up to the Billion-Euro range. As evident from the past, aviation shows certain vulnerability with regard to natural hazards. The proposal EUNADICS-AV addresses airborne hazards (environmental emergency scenarios), including volcano eruptions, nuclear accidents and emergencies and other scenarios where aerosols and certain trace gases are injected into the atmosphere. Such events are considered rare, but may have an extremely high impact, as demonstrated during the European Volcanic Ash Crisis in 2010. Before the 1990s, insufficient monitoring as well as limited data analysis capabilities made it difficult to react to and to prepare for certain rare, high-impact events. Meanwhile, there are many data available during crisis situations, and the data analysis technology has improved significantly. However, there is still a significant gap in the Europe-wide availability of real time hazard measurement and monitoring information for airborne hazards describing “what, where, how much” in 3 dimensions, combined with a near-real-time European data analysis and assimilation system. The main objective of EUNADICS-AV is to close this gap in data and information availability, enabling all stakeholders in the aviation system to obtain fast, coherent and consistent information. This would allow a seamless response on a European scale, including ATM, ATC, airline flight dispatching and individual flight planning. In the SESAR 2020 Programme Execution Framework, EUNADICS-AV is a SESAR Enabling project (project delivering SESAR Technological Solutions). The project aims at passing a SESAR maturity level V2, which includes respective service val
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Crystallization in Ionic Liquid Solutions' (CRYSTILS).

assistant: **Innovation**

Crystallization is an essential process in the manufacture of products as varied as pharmaceuticals, electronic devices or biomimetic materials. In order to obtain a crystalline product with desirable characteristics (e.g. crystal size, morphology, structural organization) for specific applications it is crucial to control the mechanism and kinetics of crystal nucleation and growth. Yet, our understanding of the crystallization reactions remains limited, especially for organic, polymeric, and protein crystals. It is recognized that the specific chemistry of a solvent affects crystal growth and nucleation kinetics, morphology, crystal size distribution and purity of precipitates. Usually different solvents with respective properties are used for particular purposes, and organic solvents are ubiquitously applied in crystallization strategies in research and industry. However there is great concern in limiting the use of organic solvents because of their negative environmental and health impact. Ionic liquids (ILs) have earned special attention from the scientific community as alternatives to replace traditional volatile organic compounds. Some attempts have been made to exploit the unique properties of these salts in crystallization processes. Nevertheless the complexity of such systems and as yet not fully characterized chemistry of ILs make understanding of the underlying mechanisms and control of resulting precipitate characteristics quite difficult. The aim of this project is to use ILs as crystallization additives in order to design the aqueous solvent with predictable and controllable effect on respective characteristics of inorganic and protein crystals. Such an approach results from a novel concept that explains dependence of the crystallization reactions on addit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analysis of absorption lines in spectra of a high redshifted quasar' in the context of a Fourth Framework call.

assistant: **Objectives**

Quasars are extremely bright nuclei of distant galaxies. Due to their high luminosity they constitute unique cosmological probes. The light emitted by the quasar is absorbed by the intervening gas clouds. The observation and interpretation of absorption lines in quasar spectra has become one of the major topics in cosmology, since it provides valuable information about the cmposition, distribution and evolution of matter in the Universe. The number of suitable quasars to be used as background sources is at present rather small, since, unfortunately, the light from bright quasars is often totally absorbed. The Hamburg group has discovered bright high-redshifted quasars adequate for detailed absorption study from observations gained with large gground-based telescopes and also with the Hubble Space Telescope (HST). The work on the quasar HS 1700-6416 (e.g. Vogel and Reimers 1995, A and A 294,377) has shown that plenty of precious information can be obtained by studying simultaneously ultraviolet and optical spectra. The analysis of the spectra of the bright (V=16.5) high-redshift (z = 2.4) quasar HE 1122- 1649 is the purpose of this project. Ultraviolet data of HE 1122-1649 have been quite recently obtained with the Faint Ojbect Spectorgraph onboard the HST and optiacl data with CASPEC at the 3.6m telescope at ESO/La Silla. The analysis of the absorption spectra allow the study of distant galaxies and of rather unevolved gas clouds which are otherwise not detectable. New results concerning the properties of the absorbing gas clouds (chemical enrichement, ionization and thermal state, distribution and evolution, confinement, etc.) and the intergalactic radiation field at high redshift are expected.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reconstruction and Computational Modelling for Inherited Metabolic Diseases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Our overall objectives are to accelerate the diagnosis, and enable personalised management, of inherited metabolic diseases (IMDs). Established academic technology for statistical genomic analysis, deep learning-based prediction of protein structure, and whole-body metabolic network modelling shall be applied to generate personalised computational models, given patient-derived genomic, transcriptomic, proteomic and metabolomic data. To train diagnostic models, a comprehensive clinical team will recruit 1,945 diagnosed patients with a wide variety of IMDs, then validate the clinical utility of personalised computational models on a set of 685 undiagnosed patients. An enhanced human metabolic network reconstruction, especially for lipid metabolism, reaction kinetics and inherited metabolic disease pathways, will increase the predictive capacity of cellular and whole-body metabolic network models.  As an exemplar for other IMDs, personalised computational modelling will be used to identify compensatory and aggravating mechanisms that associate with clinical severity in Gaucher disease. The predictive capacity of personalised models will be validated by comparison with additional empirical investigations of protein structure and function as well as metabolomics, tracer-based metabolomics and proteomics of patient-derived in vitro disease models. To maximise the potential for impact, personalised modelling software will be developed to be generally applicable to a broad variety of IMDs, and implemented in a way that is both accessible to clinicians and admissible to regulatory authorities. Sustainability will be promoted by development of a roadmap for a European foundation to aid personalised diagnosis and management of IMDs, informed by broad stakeholder consultation. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Applications of game semantics to static program analysis'.

assistant: **Objectives**

I Research Objectives and Content The main goal of this project is to show the utility of Game Semantics, a recent and very promising framework for describing the semantics of programming languages. as a formal basis for static program analysis, a technique consisting in determining the properties of programs before ever running them, used e.g. to enable optimizations in compiler technology. The techniques currently considered are (i) approximation of programs as terms in process calculi; (ii) the description of behavioural properties as modal u-calculus propositions,(iii) the use of general purpose modelchecking tools, and (iv) the use of type-based analysis techniques Training Content Edinburgh University is an exceptional research centre in the areas of formal semantics for programming languages. process calculi and model-checking, and Category Theory Furthermore, there are strong links with Imperial College. London. where groups are interested in static analysis Furthering my knowledge of these areas will cornplement nicely my background from the Ecole Normale Superieure and the University of Bologna which is mainly in Semantics and static analysis. Links with industry / industrial relevance (22)