RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Markers of prenatal metabolic plasticity and assessment of their reversibility by postnatal interventions' under Seventh Framework.

assistant: **Concept**

Inactivity and nutritional aberrations result in an expanding population of individuals with compromised metabolic function including obesity and insulin resistance. From this pool of individuals an increasing percentage develops overt diabetes leading to vast personal and social burden. Natural interventions are beneficial and exercise accompanied by weight loss can reverse insulin resistance, at least partially. Metabolic stress history has significant impact on the long-term organization of metabolic adaptive responses, especially during early stages of life (intrauterine and early postnatal). Individual variability of genetic background and metabolic-stress history coincides with the need for diverse interventions, in order to optimize metabolic control. Linking distinct markers of metabolic aberrations with genetic and metabolic stress history components will provide tools for individualized approaches for treating patients, which will facilitate our efforts to “normalize” a maladaptive metabolic profile in the context of a sedentary/hypercaloric life style. The general aim of the proposed study is to define the experimental tools that will shape a model animal system for the study of the metabolic impact of interventions that may be used therapeutically in states of compromised metabolism. The specific aims include (a) the identification of serum and tissue markers that specifically characterize the metabolic derangements associated with distinct mouse models of in utero metabolic risk and (b) the examination of the effects of nutritional, medicinal, hormonal and physical activity interventions on these markers and their association with changes in insulin resistance and metabolic balance. Establishing an experimental model that will facilitate the assessment of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Efficient Phylogenetics and the Caecilian Tree of Life' (EFFICIENT-C-TREE).

assistant: **Innovation**

The main aim of this research project is to develop and evaluate intelligent sampling strategies that will enable more efficient construction of large-scale phylogenetic trees, and ultimately the Tree of Life. The project aims to reconstruct a large, near-comprehensive phylogeny of caecilian amphibians, and to use it to compare supertree and supermatrix approaches for building trees of life, as well as to investigate experimental design strategies intended to maximize the efficiency of large phylogeny reconstruction. The most innovative part of the project will be the use of supertrees in the development of strategies to effectively identify areas of poor overlap in large phylogenies. This is virtually an unexplored, cutting-edge area in the field of systematics and supertree reconstruction. It is hoped that the strategies developed in this project will have broad applicability and will become essential to efficiently plan and successfully culminate ambitious research initiatives aiming tree of life reconstruction (with real savings in time and cost), which is primary to almost every biological study (phylogenetic knowledge is necessary for the correct classification of any organism). Hence, these results will contribute to the more efficient implementation of strategies of conservation and sustainable management of biological diversity and natural resources, which is very timely and in line with the objectives of EU environmental research under FP7. Ultimately, the proposed project will put Europe at the forefront of tree of life reconstruction, as well as of amphibian systematics and evolution (particularly of caecilians). The high quality and profile of the fellow, together with the vast expertise of the host group, and the scientific excellence of the receiving inst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'How distress alters opioid drug effects and abuse liability' under Horizon 2020.

assistant: **Concept**

As the opioid epidemic escalates, we must ask: why are opioids so addictive? Non-human animal research links addiction with the powerful relief opioids can offer to animals in distress. In humans, epidemiological and clinical studies converge upon social stressors and a poor social support network as key risk factors for addiction. Despite this, it is currently unknown how pre-drug distress might alter opioid drug effects. Tremendous resources are dedicated to charting how people feel after taking a drug, sidestepping the potentially profound influence of how people feel before they take the drug. Here, I will turn the current approach on its head. Using acute social distress induction before morphine administration in healthy humans, I will create a human model to determine the psychological, physiological and brain underpinnings of how social stressors increase opioids’ abuse liability.First, I will test the hypothesis that pre-drug distress enhances drug wanting (self-administration) but not drug liking (self-report) compared to drug effects in a control condition. Second, I will use opioid blockade to confirm or falsify the hypothesis that opioid drugs ‘hijack’ brain mechanisms underpinning social support. Third, I will determine to what extent opioid drug effects are dopamine-dependent by blocking dopamine before morphine administration. I will also apply computational modelling and functional imaging to elucidate the underlying brain mechanisms. Thus, the proposal offers a powerful new methodology for resolving hotly debated questions on the independent contributions of opioids and dopamine for reward and abuse liability.In sum, the project aims to achieve a breakthrough in our understanding of how a pre-drug social distress state can alter opioid drug mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Feasibility study of triploid salmon production' (SALMOTRIP), addressing dissemination and exploitation.

assistant: **Impact**

With the rapid growth of aquaculture seen in recent years, one major fundamental problem has arisen being the environmental pollution due to increased numbers of escapee fish interacting with wild populations. A greater public awareness, the need to protect natural resources and increase the food safety requires the development and implementation of new environmental regulations. There is therefore an urgent need to address this negative environmental impact of salmon farming. To date, two means are available 1) preventing fish escaping by improving cage design and containment or 2) produce sterile fish. Although considerable technological advances have been made in the design of cage systems, no system will be fully reliable as escapees through natural disasters are inevitable. Therefore, there is a clear need to revive the previously abandoned triploid concept as the only means, known to date, to address the environmental impact of escapees contributing to genetic pollution. Furthermore, the production of sterile fish would be very beneficial to salmon breeders as a way to protect their domesticated stocks which are the result of long and costly selection processes aiming to improve important traits such as disease resistance, growth performance and flesh quality. Triploidy would also alleviate early maturation problems and subsequent welfare associated infringements and decreased quality standards. However, prior to discussing the potential implementation of such a radical change within the salmon farming industry, previously based on equivocal results, a sounder understanding of triploid requirements and performances is needed at a commercial scale given the significant advancement in rearing protocols made throughout the production cycle over the last decades. It i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Watergate: Development of a low-cost solar desalination technology' to be submitted under Horizon 2020.

assistant: **Abstract**

The Watergate project aims to bring to the market by 2017 the most competitive desalination solution for middle scale applications, a market niche accounting for 900 Million € of annual investment in 2014. Its major value-added lies in the unique combination of a total independence on fossil fuel, the solution requiring only solar energy, and very competitive water costs ranging between 0.80€ and 2€/m3 for applications above 100m3/day. The major innovation of Watergate lies in the fact that the whole system “desalination-energy source” has been redesigned, resulting in an integrated system that solves the critical issue of the low efficiency of renewable energy desalination. The value-added of Watergate relies on two pillars: - The reduction of the size of the required solar field by more than 20% through a minimization of the energy consumption and a maximization of the energy efficiency; - The absorption of the variations in energy intensity, making it possible to work without any complementary energy source. The market potential for Watergate is substantial. It will not only target the current low to middle scale market accounting for 500,000 m3/day of yearly installed capacity, it will also boost the development of desalination in energy importing countries: Spain, Malta, Cyprus, Greece and Israel; as well as extend the scope of the market to users with no access to fossil fuel. Under Phase 1 of the SME Instrument, the feasibility study will first focus on the definition of the business positioning of Cyrga. The resulting identification of the targeted segments and the relevant business model will make it possible to develop a corresponding marketing strategy and adapt the financial plan, providing the missing parts for the elaboration of a strategic business plan b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transdisciplinary ANd Deliberative equity appraisal of transition policies in Energy and Mobility' to be submitted under Horizon Europe.

assistant: **Abstract**

Numerous attempts of implementing transition pathways across Europe illustrate the difficulty of designing policies that combine efficient climate action and justice considerations. One reason is that the socially diverse, and thus also geographically dispersed demands and vulnerabilities of potentially affected groups do not appear as a well-structured input at any stage of the policy-making process. Therefore, TANDEM will test an innovative transdisciplinary approach in five different case studies in Spain, Belgium, Finland, Poland and Austria that address controversial transition policies in energy and mobility affecting urban and rural populations. The TANDEM project aims to design a methodology allowing policy makers to create and implement inclusive and just transition pathways by involving potentially affected citizens, public authorities, the private sector and other relevant stakeholders. It relies on combination of accessible and complementary methods: deliberative visioning build on art-based approaches, system mapping, assessment and appraisal methods. These methods constitute the backbone of a series of three deliberation panels with citizens. In these panels TANDEM invites participants to create their visions, perspectives and narratives on just transition policies and to define their own criteria and interventions. This deliberation process will guide a systemic impact assessment that will inform individual appraisals of the interventions. Public authorities will be involved at the beginning and end of each panel to provide insights on political, social and economic factors that should be taken into consideration. Furthermore, private companies will be invited to participate through interviews and surveys. TANDEM will thus develop a transdisciplinary appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FROM PATIENT DATA TO PERSONALISED HEALTHCARE IN ALZHEIMER'S DISEASE', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Dementia causes long and oppressive suffering to patients and their relatives and imposes enormous costs on society. About 25 million people suffered from dementia in 2000. As a 4-fold increase of this number is expected by 2050, dementia is one main health issue of the next decades. Alzheimer's disease (AD) covers 60-70% of all dementia cases. No cure for AD exists, and effective and reliable early diagnostic techniques are lacking. Early diagnosis and progress monitoring of AD is a central part of treatment once future drugs and prevention strategies become available. There is a strong indication that different biomarkers provide a reliable and early indication of AD prior to its major clinical signs. However, optimal early diagnosis requires information from a combination of different biomarkers to be used in a clinically useful way.The objective of PredictAD is 1) to find the best combination of biomarkers for AD diagnostics from heterogeneous data (imaging, electrophysiology, molecular level, clinical tests, demographics) and 2) to develop clinically useful tools integrating the optimal biomarker results. Comprehensive biomarker discovery techniques and rigorous statistical models will be developed using the consortium's large databases. The accuracy and usability of models and tool will be clinically evaluated. The cost-effectiveness of heterogeneous data in AD diagnostic procedures will be studied.By reaching its objectives, PredictAD provides an efficient and reliable solution for early AD diagnosis in clinical practice. The impacts on patients, their relatives and society are reduced suffering and costs. As we are living in the dawn of an era of new drugs and prevention strategies combined with increasing AD prevalence, now is the time to exploit the vast poten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Wireless magnetothermal entero-modulation' in the context of a Horizon Europe call.

assistant: **Objectives**

Gastrointestinal (GI) disorders affect over 40% of the world population. Pharmacological agents that modulate cell function and subsequently impact processes involved in such disorders, suffer from limited spatiotemporal specificity and accompanying side effects. Despite the advances in the field of bioelectronic medicine which have enabled localized modulation of electrogenic cells, it still requires invasive hardware, impeding their use in soft and continuously moving organs. We recently showed that magnetic nanoparticles injected into a deep solid organ and exposed to alternating magnetic fields (AMFs), dissipate heat that can trigger localized calcium signaling mediated by endogenously expressed heat-sensitive ion channels. However, penetrating the sensitive and hollow intestine tissue is challenging. This proposal aims to develop a novel approach for remote activation of the intestine via adhesive materials. To achieve this goal, an implantable, biocompatible and stretchable magnetic gel will be designed with controlled adhesiveness, allowing for its effective adherence to tissues and detachment. The magnetic gel can be remotely controlled to dissipate heat under AMFs. Prior to attempting thermal stimulation of the intestine, a proof-of-principle demonstration will be performed in the adrenal gland, a solid organ which expresses heat-sensitive ion channels. Next, the gel properties will be tailored to the intestinal tissue and the activation of heat-sensitive ion channels in the colon will be thoroughly characterized ex vivo.  Finally, in vivo entero-modulation will be demonstrated, while addressing barriers associated with use of magnetic nanomaterials in in vivo models and modulating parameters to achieve short latency between stimulation onset and cell response.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Open Computing Infrastructures for Elastic Services' (CONTRAIL) targeting Seventh Framework.

assistant: **Abstract**

In the future of corporate IT, companies will rely on highly dynamic distributed IT infrastructures. Federation models are envisioned where a given organisation will be both a Cloud provider during periods when its IT infrastructure is not used at its maximal capacity, and a Cloud customer in periods of peak activity.The main contribution of CONTRAIL will be  the development of an integrated approach to virtualization, offering Infrastructure as a Service (IaaS), services for federating IaaS Clouds, and Platform as a Service (PaaS) on top of federated Clouds. This service stack will be part of the CONTRAIL open source system, facilitating industrial up-take of Cloud computing. The main outputs of CONTRAIL are a collection of infrastructure services offering network, computation and storage as a service; services to federate IaaS Clouds; a set of high level services and runtime environments for typical Cloud applications, including efficient map/reduce, scalable service-oriented application hosting, and automatic workflow execution; and a set of applications and use cases from the domains of e-business, e-science, telecommunication and media using and demonstrating the CONTRAIL system.CONTRAIL leverages the open source XtreemOS system, developed in the successful XtreemOS European integrated project and which was designed for large scale dynamic infrastructures. XtreemOS integrates services for data, application, security and community management that can be adapted to provide a unified solution for building private, public and federated Cloud infrastructures. CONTRAIL has core virtualization technology integrated with its high-level services and its Cloud management facilities.This unique approach of covering the whole Cloud" from the core infrastructure, via federation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Assessing the Toxicity of nitrates in a host-Parasite system' (Para-Tox).

assistant: **Innovation**

Anthropogenic nitrate contamination has increased significantly in recent decades but its effects on aquatic species are still poorly understood. The toxicity of nitrates has long been underestimated compared to ammonia and nitrites. However, new evidence indicates that long-term nitrate exposure not only impairs growth, fertilization and fecundity, but also weakens the immune response decreasing disease resistance in aquatic species. Nitrates can favour diseases through direct effects on parasite performance and/or indirectly by influencing host-pathogen interactions . Using a well studied host-parasite system, the guppy (Poecilia reticulata) and its native pathogen (Gyrodactylus turnbulli), this fellowship will assess the effects of nitrates on life-history traits and physiological functions. Specifically, we will  i) determine the effect of nitrate on feeding behaviour, body condition, reproduction and immunity in guppies; ii) analyze any interaction effects between nitrates and pathogens; iii) determine the role of acquired immunity in adult fish; and iv) test for maternally inherited immunity transfer in F1 offspring. Pathogens and nitrates threaten both wild and captive fish populations, therefore the findings of this fellowship will have repercussions for aquaculture and water resource managers. Although the guppy has been widely used in a range of evolutionary, parasitological and toxicological studies, few studies have used this host-parasite system in ecotoxicology. In addition, this study will examine the disruptive endocrine effects of nitrates on the fish immune system. Understanding the effects of nitrates on this host-parasite system will increase our knowledge about fish and parasite as bioindicators of aquatic ecosystem health, and the consequences of n