RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Eat me microglia: lipid scrambling as a signal for synaptic pruning' under Horizon 2020.

assistant: **Concept**

The development of the nervous system is associated with the generation of excess neuronal synapses that is followed by their tightly controlled removal, a process known as synaptic pruning. In the primate cortex, for example, 70% of connections are selectively lost within the first six months of life. Why are so many synapses lost, what determines which synapses are eliminated, what are the molecular mechanisms involved, and what are the consequences of not getting it right? Recently, several studies have presented microglial phagocytosis as a mechanism for synapse elimination. Neural activity plays a role in synaptic pruning, but the neuronal “eat-me” signals that mediate phagocytic recognition and engulfment of synapses remain to be identified. We hypothesize that cell surface exposure of the lipid phosphatidylserine (PtdSer) is a key “eat-me” signal for synaptic pruning during development. Therefore we aim to define the role of PtdSer in synapse-microglia interaction and to assess the morphological, circuit maturation and behavioural effects of impaired PtdSer exposure in phospholipid scramblase-deficient brains. We propose to use novel custom-made tool to observe PtdSer exposure without interfering with PtdSer-dependent cellular interactions and two mouse models with disrupted PtdSer exposure to study how PtdSer contributes to circuit refinement. The identification of an “eat-me” signal will shed the light on what distinguishes synapses destined to be eliminated from those that survive and will be the first step in understanding why the majority of synapses are turned over during brain development before the final connectome emerges. As aberrant brain wiring during development is known to be defective in a wide range of neurodevelopmental disorders, understanding h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Spin correlations by atomic design'.

assistant: **Objectives**

Unexpected physical phenomena occurring in materials often result from the complex interplay between spins on the atomic scale. The field of quantum magnetism aims to capture the rich emergent physics that arises when multiple spins interact. While experimental techniques are available to probe the global quantum magnetic properties of materials, they fail to reveal the role of local features such as individual defects or phase boundaries. I propose to use custom-designed spin lattices created by low-temperature scanning tunnelling microscopy (STM) to probe spin correlations locally at the atomic scale, providing the ultimate tool to trace particle-like excitations (spinons) as they propagate. Since these excitations exist on timescales that are much too short to be accessed directly in real time, I will introduce ‘spinon traps’: atom-built detector bits that record the presence of a spinon and store this information immediately on the atomic scale, to be read out at a later time. This approach opens the possibility to study emergent material properties as a function of system size and test theories for quantum magnetism that were previously experimentally inaccessible.Based on preliminary experiments in my group that indicate the feasibility of SPINCAD, I will realize and demonstrate the spinon trapping technique by employing it to the study of attractive interactions between spinons, which may be forged independently through atom manipulation. In addition, I will observe the motion of spinons through two-dimensional frustrated spin lattices. Being the first technique to perform local injection and readout of excitations in custom-designed spin structures, SPINCAD will generate a long-lasting synergy between the fields of theoretical quantum magnetism and experimental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Laser-Initiated Liquid-Assisted Colloidal Lithography' (LILAC) targeting Seventh Framework.

assistant: **Abstract**

The overall purpose of this research project is to develop and apply a novel laser-initiated liquid-assisted colloidal lithography (LILAC) method for controllable nanostructuring a wide range of surfaces. The method combines, for the first time, ultra-short laser pulses, medium-tuned optical near-field effects and colloidal lithography to achieve surface structuring of materials like Si, III-V semiconductor, biomedically relevant metals and polymer surfaces. The detailed mechanisms underpinning the pattern formation depend on the many experimental process variables: laser wavelength and intensity/fluence; choice of liquid; size, shape, nature and packing of colloid particles; choice of solid surface, etc. Accordingly, the 2-year project proposed here has three interconnected aims:1. To investigate the mechanisms of the pattern formation by systematic variation of relevant experimental parameters. To this end, we will vary: the nature of the liquid used to produce radical species at the liquid-substrate interface, laser pulse duration and wavelengths, the colloidal lithographic masking strategy, substrate surface chemistry, etc.;2. To exploit the LILAC method to generate surface patterns with unprecedented physical and chemical sophistication and complexity;3. To undertake preliminary investigations of the utility of specific surface micro-structures for tissue engineering and sensor applications.This project will help Dr. Magdalena Ulmeanu to embark upon an independent research career and to acquire new practical and theoretical skills necessary for her career development in ultra-short laser processing of surfaces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Participation in the Nuclear Science Symposium and Medical imaging Conference, Lyon, France October 2000 (NE)' (NE) targeting Fifth Framework.

assistant: **Abstract**

The Nuclear Science Symposium and Medical imaging Conference (NSS-MIC) brings together annually the scientific communities active in radiation detectors and in medical imaging. It is an event of high scientific relevance in the field, recognized at world level.In 2000 this conference will take place in Europe for the first time, thus offering a unique opportunity to young European researchers to participate at a lesser cost. Notwithstanding the central location of the event in Lyon, France, young researchers may find it difficult to receive support covering travel, subsistence, registration fees and enrolment in tutorials.This request is meant ordinarily to provide financial help to young researchers from Member States of the European Union to participate in the conference and more specifically to enrol in the tutorials.Objectives:1 - To subsidize the participation of young researchers in the short courses and tutorials offered by the conference programme;2 - To contribute to the payment of the teachers for the short courses and tutorials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'an advanced thermal insulating material with improved properties based on NanoCELLular polymers' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The overall aim of nCell project is to introduce in the international market a novel generation of advanced thermal insulating materials, which are based on low-density nanocellular polymers. The concept of nCell lies in the reduction of the cell size of the insulating materials from the micro-scale to the nano-scale. Their disruptive properties, at least 2 times better than those of the best conventional thermal insulating materials, combined with competitive prices will allow a quick penetration in the market. Currently, 9600 millions of m2 of thermal insulating materials are annually produced which are mainly applied in the building sector. However, this sector is subjected to very strict regulations regarding energy efficiency due to current EU policies. In fact our project is clearly aligned with the main EU policies regarding energy efficiency. For these reasons, there is a good business opportunity for companies able to produce highly efficient and cost-effective thermal insulating materials. CellMat Technologies wants to introduce their nCell materials in this market and the funding provided by SME instrument represents an excellent opportunity in the current business plan of the company, which will be based on produce and commercialize nCell materials. The specific objectives in this Phase 1 of SME instrument is the development of a feasibility study in order to study and evaluate the main working parameters of our current business plan and to reconsider them if necessary before entering a Phase 2 project.. The business plan of the company has been initially estimated for the period 2017-2022 with the production at industrial scale starting in 2019. We have predicted that the accumulative sales will be of around 38 million euros in the period 2019-2022 with a p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of porous metal fiber components for various industrial high temperature applications', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives and content In automobile, aircraft, and metallurgical industry, highly porous components with pronounced high temperature (HT) properties are needed. Present metal-based solutions suffer from limited porosity, limited HT properties due to only a small choice of metal compositions, insufficient workability of the fibre preforms, and a very high price. In case of ceramics, high mechanical brittleness and high sensitivity to thermal shock restrict the possible range of applications. Moreover, joining of ceramic to metal still remains a problem. Therefore, the final objective of this industrial research project is to develop, through innovative low cost technology, a new generation of high temperature, low-density porous metal fibre components. Substantial cost savings of up to 40% and more are expected. A significant increase in service temperature, time, and HT strength and the comparably low cost of the final product will provide innovative solutions to existing problems in HT filtering, catalyst devices, and thermal shielding. Porosities of up to 97% are expected to open up a whole new field of applications for porous metal fibre products. For the new components, a three-step process is to be developed: Fibre production by melt extraction, preform fabrication by bulk or textile techniques, preform consolidation/shaping by sintering, brazing, or chemical deposition. Unlike prevalent mechanical fibre production techniques, melt extraction allows the production of fibres from a large number of different alloys at significantly lower cost. Alloy compositions include intermetallics and the addition of noble elements. This provides the basis for drastically improved HT mechanical properties, oxidation resistance, and the possibility to obtain intrinsic catalytic a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Limited proteolysis mechanisms in plants for selective protein translation to improve heat tolerance'.

assistant: **Concept**

Heat waves threaten agriculture in the EU and worldwide. Exactly how we can protect our crops precisely and rapidly from heat is a lingering question with important implications for future food security. My aim with PLANTEX is to explore the potential of a rapid stress response that my lab has discovered and incorporate this knowledge into the design of new breeding strategies to improve crops. To bolster heat tolerance, I propose an innovative approach for the control of protein production networks by repurposing proteolytic pathways that control the dynamics of organelle-like assemblies known as condensates.My lab pioneers the study of proteolysis on the formation of condensates with unique properties that allow them to store functionally related proteins and RNAs. I dubbed the networks in these condensates that we discovered “coregulons”. These coregulons are responsible for undocumented rapid and synchronized stress responses, for example during heat, that depend on proteolysis. I hypothesize that the discovered condensates ensure an unappreciated rapid response to stress that is important for plant acclimation and that this knowledge can be exploited to engineer desirable traits in crops.In this project, I propose 1) to use our approaches to collect an extensive dataset of coregulons important for growth and environmental adaptation in the model organism Arabidopsis and the agricultural-relevant crop tomato, 2) to characterize novel mechanisms involving proteolysis of coregulons by refining and developing new approaches of protease-substrate capture, and 3) design and implement innovative strategies based on cutting-edge genetic approaches to improve the tolerance of tomato to heat waves.My objectives are ambitious but potentially game-changing by providing approac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Role of Cortico-Hippocampal Interactions during Memory Encoding' (CHIME) under Horizon 2020.

assistant: **Objectives**

This research proposal’s goal is to investigate the role of cortico-hippocampal interactions during the encoding and consolidation of a memory. Current memory consolidation models postulate that memory storage in our brains occurs by a dynamic process- a recent episodic experience is initially encoded in the hippocampus, and during off-line states such as sleep, the encoded memory is gradually transferred to neocortex for long-term storage. One potential neural mechanism by which this could occur is replay, a phenomenon where neural activity patterns in the hippocampus evoked by a previous experience reactivate spontaneously during non-REM sleep, leading to coordinated cortical reactivation. While previous work suggests that hippocampal replay is important for encoding new memories, how memory consolidation is accomplished through cortico-hippocampal interactions is not well understood. This research project has three major aims- 1) examine how cortical feedback influences which spatial trajectory is replayed by the hippocampus, 2) investigate how the hippocampal replay of a behavioural episode modifies cortical circuits, 3) measure the causal role of cortico-hippocampal interactions in consolidating memories. We will record ensemble activity from freely moving rats during an auditory-spatial association task and during post-behavioural sleep sessions.  We will focus our ensemble recordings on two brain regions: 1) the dorsal CA1 region of the hippocampus, where the phenomenon of sleep replay has been most extensively examined, and 2) auditory cortex, a region of the brain critical for both auditory perception and long-term memory storage. This work will use behavioral and molecular-genetic techniques in combination with large-scale electrophysiological recordings, to h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Full Service AudioVisual Infrastructure for Metropolitan Access Networks' to be submitted under Fifth Framework.

assistant: **Abstract**

VisionAIR integrates, installs and operates four large trials in European cities by advancing existing infrastructure and following a full service convergence approach. The project implements a state of the art service delivery network enabled by next-generation network technologies, with a scope to validate these concepts in real-world trials. The trials are operated by municipalities, in accordance with their strategic plans of becoming specialized service providers in their area of authority, following the paradigm of US and large EU municipalities that create large, closed user groups for the benefit of their habitants, as a complement to the existing service offerings of typical Telcos and Internet Service Providers. Operators and Consulting companies participate in the project, to align the specialized, social interests of the municipalities with the pure business nature of the interests of the providers and operators.Objectives:(1) Exploit existing, next generation fiber and DSL networks in four European cities, set-up large trials and experiment with convergent, IP voice, data and video based services;2) deploy service delivery platforms based on existing, owned or leased access infrastructure;3) perform 1.5 years of extensive user trials with broadband services and experiment with service bundles deployment based on the OSGI framework;4) validate equipment interoperability and service interworking as well as to offer end-user privacy, data security, and QoS;5) develop and validate usage scenarios, carry out extensive human-centric studies with the help of independent human-aspect analysis consultants;6) develop & validate business models to be used as a paradigm for massive deployment;7) contribute to standards regarding service bundle deployment over convergen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Spontaneous Emission of Semiconductor Quantum DotsControlled in Optical Microcavities'.

assistant: **Objectives**

The development of efficient sources of single photons is a major challenge in the context of quantum communications and quantum information processing. The state-of the art solid state based single photon sources (SPS) are based on III-V quantum dots embedded in micropillar cavities.Despite intensive research two main challenges remain to date: First, the efficiency of single photon generation is low, due to the limitations in efficient micropillar output coupling. Second, the degree of indistinguishabil ity of the photons obtained is insufficient for practical applications.Here we propose to address both of the aforementioned challenges. In a first research phase single photons will be generated using quantum dot embedded in photonic crystal microcavitie s. In a second phase, a novel approach will be introduced in order to significantly increase the SPS efficiency; a quantum dot microdisk will be directly coupled to an optical tapered fiber.These novel SPS should find utilisation in cascadable quantum gates and quantum information systems or in experiments on the fundamental concepts of quantum mechanics, two areas that mobilize the international physics community and in which Europe has a lead.The training aspects of the project involve a significant enlargement of the scientific field of the applicant into a fast-advancing new area of quantum optical devices, acquisition of cutting-edge nanofabrication technical skills, and the development of project management and apprentice guidance methods, essential for an independent research career.The hosting institution is the Laboratory for Photonics and Nanostructures (LPN), the main French nanofabrication facility and one of the leading laboratories in nanofabrication and quantum optics worldwide.The applicant is a German
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New water based, crosslinker-free leather finishing system through ultraviolet radiation curing' (1998-2002).

assistant: **Innovation**

The project aims to implement a new technology applicable to leather finishing, by the synthesis of new UV curable polymers and developing their applicative formulation to the specific requirements of this material: flexibility, elasticity, fastness, adhesion, look, handle, etc., in such a way that permits to reach the maximum quality performance without the current use of solvent based coats or water based externally cross linked systems, such as poliaziridines or isocianates, which are harmful for workplace application and for the environment. The secondary objectives are:- the synthesis of the suitable polymer able to afford the required characteristics in use - the building of the mechanical equipment necessary for a correct application of the method: coating machine and UV -radiation tunnel adapted to leather characteristics - the formulation of finishing compositions with the appropriate additives for the several applicative purposes, thus developing the products that will be directly marketed for industrial use.