RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SYSTEMS ANALYSIS OF ADULT AND PEDIATRIC RESPONSES TO THE VSV-ZEBOV EBOLA VACCINE - Sofia ref.: 116068' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The vesicular stomatitis virus (VSV)-Zaire Ebola vaccine (VSV-ZEBOV) is a recombinant vector-based vaccine in which the VSV envelope glycoprotein was replaced with the Zaire strain Ebola virus glycoprotein. Within one year of the initiation of its clinical development, the VSV-ZEBOV vaccine has demonstrated safety, immunogenicity and a remarkably high protective efficacy against Ebola Virus Disease, using a high vaccine dose (2x107 pfu) in the WHO-sponsored VSV-ZEBOV ring-vaccination trial in adults in Guinea. However, several key questions remain unanswered, including its mode of action, its correlation with protection and reactogenicity, the expected duration of protective efficacy and determinants of long-term responses, the influence of baseline immunity on vaccine “take”, and the vaccine efficacy in children - a most vulnerable population. Following the interruption of the 2014-2015 Ebola Virus Disease (EVD) outbreak, these questions, being central to the future licensing and use of VSV-ZEBOV, may not be addressed by collecting field data. The VSV-EBOPLUS project therefore proposes to use cutting-edge systems biology approaches to address these key questions, capitalizing on the unique availability of large series of extremely well defined samples from clinical vaccine studies with the VSV-ZEBOV vaccine in three different continents (Europe, Africa, US).Specifically, the overarching objective of VSV-EBOPLUS is to comprehensively decipher the immune and molecular signatures of adult and pediatric responses elicited by VSV-ZEBOV through systems biology approaches. VSV-EBOPLUS will benefit from harmonized and standardized clinical trial protocols, in almost 1’000 adults, adolescents and children.We propose:1) to examine early (days 0 to 7) blood samples from 512 adult
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Developing new therapeutics for Friedreich ataxia' (FAST-DEVELOPS) under Horizon 2020.

assistant: **Objectives**

Friedreich ataxia (FRDA) is a devastating neurodegenerative orphan disease that affects children and young adults, and has no approved therapy. The disease progressively brings patients to severe disability and significantly reduces life expectancy. The genetic defect underlying the disease causes FRDA patients to produce only low amounts of the mitochondrial protein frataxin, compared to normal subjects. Low frataxin results in the accelerated death of peripheral sensory neurons, causing the disease. Goal of any tentative specific therapy is therefore to increase frataxin levels in FRDA patients. Building on our original discovery that unveiled the mechanism of physiological frataxin degradation, we are developing new chemical entities that manage to increase frataxin in FRDA patients cells by preventing the degradation of frataxin. This effort is currently funded by an ERC Advanced Grant (Friedreich Ataxia Seeks Therapy – FAST, project number 293699). We now plan to bring some of the most promising compounds emerging from the above mentioned ERC-funded project, to the proof of concept (POC) of efficacy in living sensory neurons derived from FRDA patients. This will be achieved by demonstrating that our compounds are able to increase frataxin in sensory neurons generated from patient-derived induced pluripotent stem cells. A defined path for the further de-risking and development of compounds that have reached the POC stage, has been discussed together with Cydan Development, the leading orphan drug accelerator, and the VC firm Kurma Partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New Directions in Seismic Hazard assessment through Focused Earth Observation in the Marmara Supersite' (MARSITE).

assistant: **Concept**

The recent devastating earthquakes and associated tsunamis in Japan, Indonesia, and Haiti, which killed more than half a million people, highlighted how mankind is still far away from a satisfactory level of seismic risk mitigation.  Among the regions around the Mediterranean Sea for which earthquakes represent a major threat to their social and economic development, the area around the Marmara Sea, one of the most densely populated parts of Europe, is subjected to a high level of seismic hazard. For this region the MARSITE project is proposed with the aim of assessing the “state of the art” of seismic risk evaluation and management at European level. This will be the starting point to move a “step forward” towards new concepts of risk mitigation and management by long-term monitoring activities carried out both on land and at sea.The MARSITE project aims to coordinate research groups with different scientific skills (from seismology to engineering to gas geochemistry) in a comprehensive monitoring activity developed both in the Marmara Sea and in the surrounding urban and country areas. The project plans to coordinate initiatives to collect multidisciplinary data, to be shared, interpreted and merged in consistent theoretical and practical models suitable for the implementation of good practices to move the necessary information to the end users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Discovery of molecular markers for the inverse relationship between platinum and taxane resistance in cancer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Abstract  Aim: To identify a gene and protein expression pattern associated with platinum resistance and taxane sensitivity in a panel of drug-resistant cancer cell lines.  Background: Despite the success of early detection programs and surgical techniques for the treatment of cancer many patients will still require chemotherapy. Initial responsiveness to chemotherapy is high, however the majority of patients ultimately relapse with resistant disease. This research proposal will examine resistance to two commonly used classes of chemotherapy, platinums and taxanes. When cancer cells become resistant to platinum chemotherapy they often become sensitive to taxanes and vice versa. This inverse relationship happens in all cancer types and the mechanism of this relationship is not understood.   Research Project: This project will study gene and protein expression in a large panel of drug resistant cell lines in an attempt to understand the mechanism of the inverse resistance relationship between platinums and taxanes. This process will discover a set of molecular markers predicting the inverse relationship between platinum and taxanes. These have the potential to be translated to the clinic and be used to identify patients likely to respond to platinum or taxane chemotherapy.   Outcomes: The success of research projects like the one described in this application have the potential to revolutionise cancer therapy by individually tailoring chemotherapy. This will significantly increase the response rate of both platinum and taxane chemotherapy as it will allow the identification of patients likely to respond to treatment. Patients identified as being resistant to both agents could then be treated with alternative chemotherapy. The understanding of the mechanism of the inverse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Rec-a-independent recombination between tandemly repeated sequences in escherichia coli' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The main objective of this work is to understand the processes that may influence the stability of long repeated sequences in the genome of micro-organisms. Previous results showed that, in E. coli recombination between .andemly repeated sequences is independent of RecA and of other homlogous recombination functions. However, two pathways can be activated by mutations that stimulate recombination. One is RecA-independent, and is activated by a mutation in the polymerase III gene. Another is RecA-dependent and is activated by a mutation in the uvrD gene. Both pathways will be studied here.To characterise the role of polymerase III in recombination, different polymerase mutants will be tested searching specifically for a possible correlation between the mutator and deletion-prone properties of the polymerases. To analyse the reasons for the hyper-recombination phenotype of uvrD mutants, we will test whether this phenotype is correlated with the defect in the repair of lesions and/or the repair of mismatches In addition, new hyper-recombination mutants isolated in the laboratory will be characterised They may reveal new pathways of tandem repeat recombination or improve our understanding of the two known pathways. The characterisation of functions that stimulate recombination may help to define strains i which the stability of the repeated sequences is increased. Training content (objective, benefit and expected impact) Learning of bacterial genetic of repair, replication and recombination while understanding the process that control stability of repeated sequences can be of particular importance both in the context of biotechnology and for fundamental knowledge. This work combines the use of molecular biology and E coli classical genetics f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'From the Milky Way to the cosmic large-scale structure' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Wide field panoramic telescopes will become a major force in astronomy over the next decade. They will address a rich set of scientific problems, from ``killer asteroids'' to the cosmic dark energy. Pan-STARRS-1 (PS1), built by the University of Hawaii, is the first of this new generation of telescopes. European astronomers in Germany and the UK, including in the PI's host institute, make up a large fraction of the Science Consortium that, over the next 4 years, will exploit the data. This proposal is focused on the use of PS1 for cosmology. I propose a programme that combines state-of-the-art cosmological simulations and modelling with high-level analyses of the data. The goal is to test core assumptions of the standard cosmogonic model, LCDM, on scales and at epochs where it has not been tested before and where it can, in principle, be ruled out. At the same time, these tests will advance our understanding of the main constituents of our universe (dark matter and dark energy) and of the processes of galaxy formation and evolution. Two types of structure at opposite ends of the cosmological scale, the Milky Way and the large-scale distribution of galaxies at redshifts z<1.5, are ideally suited to this purpose. Studies of the Milky Way will test LCDM predictions for the hierarchical assembly of galaxies and the structure of their dark matter halos. Studies of the galaxy distribution will test LCDM predictions for the growth of structure and the connection between galaxies and dark matter. To link theory and data, I will construct mock catalogues using very large cosmological simulations and sophisticated modelling techniques. These catalogues will have a much broader applicability that just PS1 and I will make them publicly available using e-science techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Example based understanding and translation systems'.

assistant: **Innovation**

This project aims at developing Machine Translation (MT) and Language Understanding (LU) systems for limited-domain applications, which require text and/or speech input, using Example-Based (EB) techniques. Compared with more traditional Knowledge-Based approaches, much lower development costs are expected.However, overcoming some of the limitations of this system constitutes a major requirement in order to enable the scaling-up necessary to achieve useful performance in more complex tasks. Hence, additional research is required:- to develop appropriate extensions or modifications to the presently adopted techniques;- to explore alternative approaches to the underlying learning problem; and,- to study adequate techniques for non-expensive data collection in specific applications. This research constitutes the present project.Important benefits are expected from the results. Machine Translation and multilingual Language Understanding systems will have a major impact on many fields of human activity, where users would naturally interact with both humans and computers in their native language (text or speech). This has particular relevance in the European Community due to its multilingual nature. In addition to these general benefits inherent to speech-input MT and LU systems, the following derive from the approaches chosen in this project:- the use of EB techniques is expected to dramatically reduce the development costs in many specific domains;- the tight integration of acoustic-phonetic, lexical, syntactic and translation models leads to more robust speech-input systems, compared with the more conventional, decoupled approach;- these techniques give the capability of translating input sentences into adequate descriptions of the actions to be driven by the computer, thu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mathematics and Materials Science for Steel Production and Manufacturing' (MIMESIS).

assistant: **Concept**

The five partners EFD (Norway), SSAB, Outokumpu, and University of Oulu (Finland), and WIAS (Germany) propose an EID programme on Mathematics and Materials Science for Steel Production and Manufacturing, where eight PhD projects are jointly carried out, providing a unique interdisciplinary and inter-sectorial training opportunity. The research is focussed on three major topics - induction heating, phase transformations in steel alloys, ladle stirring. Two theses concern hardening: one is the hardening of helical and bevel gears by an optimized single or multi-frequency approach and the other is a novel idea about the hardening of the inner surface of pipes. Two of the theses are related to induction heating applications in the production of high-frequency welded pipes and for pre- and post-heating in the thermal cutting of steel plates. Two theses are concerned with phase transformations during steel production and the final two theses are related to secondary metallurgy in the ladle, optimal alloying strategies and an inverse problem related to stirring efficiency.Despite the fact that most theses projects deal with established processes, they are not fully understood nor fully controllable from a quality point of view. Improved and optimized process control requires quantitative mathematical modelling, simulation and optimization of the complex thermal cycles and thermal gradients experienced by the processed material. Such models require an understanding of the behaviour of the materials from a materials science and phase transformations perspective. Tailored industrial on-site trainings, customized courses in physical modelling and testing of steels as well as numerical simulation of induction heating and flow phenomena combined with scientific research in carefully
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Past Natures for Future Conservation – Current Narratives and Historical Human-Wildlife-Land Relations in Southern Africa and the European Alps' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Conservationists often use ‘historical’ arguments to justify their visions of which groups of human and non-human species should live where and how. Imagined pasts are central to influential concepts and practices of conservation, such as re-wilding, species re-introduction or landscape restoration. These narratives range from vague references to past equilibriums, that need to be saved, to more specific baselines of past distribution of certain species, that need to be restored, to the re-creation of specific past landscapes in new settings. Historians have hardly contributed to these historicized arguments. Following recent calls for conservation humanities, I apply historiographical methods to engage with conservationists’ ideas of past human-wildlife-land interactions and practices in Southern Africa and the European Alps. Firstly, I analyze, contextualize and compare how conservation organizations use imagined past human-wildlife-land relations and develop a typology of historical conservation narratives. In Southern Africa, conservationists present “Africans” as naturally knowing how to live in their environment or as a threat to nature. In Europe, conservationists’ narratives present historical people as experts or masters of nature. Secondly, I research specific historical moments in both regions, to juxtapose conservation narratives with localized analyses of historical changes in human-wildlife-land relations. Thirdly, by combining critical historical analyses of cases in the Global South with those of Europe, I challenge powerful conservation narratives that often perpetuate global power structures.By this, I critique ongoing conservation debates and practices, and offer novel perspectives of multi-species pasts. A thorough understanding of these pasts is cru
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Researchers for Humanity 2022-2023' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The main goal of “Researchers for Humanity 2022-2023” will be to bring researchers closer to the general public and to increase awareness of research and innovation activities, with a view to supporting the public recognition of researchers, creating an understanding of the impact of researchers' work on citizens´ daily life and encouraging young people to embark on research careers. We will also focus on promoting the European dimension of the event and on increasing the public’s awareness, making European Researchers’ Night 2022 and 2023 editions the most interesting and awaited events in terms of science, research and education. The two editions will be linked with continuous activities related to Researchers at schools and pre-events and the results of these activities will be presented to the public at the actual events. During the events, the public will have the opportunity to better understand science projects and researchers’ ideas and motivation by taking part in interactive hands-on sessions, learning by doing, education through play, as well as being encouraged to have interesting talks with the researchers themselves. Our widely spread national network of cities involved in organizing European Researchers’ Night will continue to be an important factor when it comes to increase awareness among the general public, promoting the goals of the event and creating a large community of researchers involved. Based on the long-lasting relationships, the partnerships will be carried on with the main actors from mass-media and most of the important players in private research, universities and non-formal education institutions and, through Researchers at schools activities, the number and quality of these partnerships will significantly improve.