RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Aging Lungs in European Cohorts' in the context of a Horizon 2020 call.

assistant: **Objectives**

This programme of work will advance the understanding of the combined effects of factors that cause poor lung function, respiratory disability and the development of COPD . This will be achieved by examination of determinants of lung growth and lung function decline within existing cohorts that cover the whole life course, and which have followed, in detail, the respiratory health status of over 25000 European children and adults from the early 1990’s to the present day.  Following a comprehensive programme of risk factor identification we will generate a predictive risk score.  The programme includes  1) identification of behavioural, environmental, occupational, nutritional, other modifiable lifestyle, genetic determinant of poor lung growth, excess lung function decline and occurrence of low lung function, respiratory disability and COPD within existing child and adult cohorts 2) generation of new data to fill gaps in knowledge on pre-conception and transgenerational determinants and risk factors 3) validation of the role of risk factors by integration of data from relevant disciplines, integration of data from the cohort-related population-based biobanks and exploitation of appropriate statistical techniques 4) generation of information on change in DNA methylation patterns to identify epigenetic changes associated with both disease development and exposure to specific risk factors  5) generation of a predictive risk score for individual risk stratification that takes account of the combined effects of factors that cause poor lung growth, lung function decline, respiratory disability, and COPD and 6) implementation of an online interactive tool for personalised risk prediction based which will be disseminated freely and widely to the population, patients and health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a TB vaccine in Africa' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Despite the millions of deaths from tuberculosis each year and the threat of increased drug resistance, tuberculosis vaccine development has been hugely under-resourced. We set out here to evaluate the safety and immunogenicity of new subunit Constructs in Africa, a continent in desperate need of an effective tuberculosis vaccine. We shall employ two attenuated poxvirus vectors, modified virus Ankara and the FP9 adios strain that both have a marked capacity to boost pre-existing T cell responses, each expressing the secreted mycobacterium antigen, Ag85A. We shall initially test the vaccines individually at different doses and then in heterogonous prime-boost regimes to identify an immunisation regime that works well both in non-infected individuals and also in those already infected by M tuberculosis, a post-exposure vaccination group. In parallel we shall measure the incidence of tuberculosis infection and disease in various high-risk cohorts in this region to identify a group in whom tuberculosis subunit vaccines may in future be tested efficiently.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bringing Excellence to Transformative Socially Engaged Research in Life Sciences through Integrated Digital Centers' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The project “Bringing Excellence to Transformative Engaged Research in Life Sciences through Integrated Digital Centres - BETTER Life” will establish a European Digital Centre of Excellence for fostering Socially Engaged Research (SER) in Life Sciences, as well as seven regional centres operating in their surrounding ecosystems. This inter-institutional support structure addresses the lack of collaboration between early career researchers and the non-academic sectors by designing tools, standards, and framework conditions under the umbrella of the EU centre and implementing these solutions in the regional ecosystems. The project aims to support the development of inter-institutional capacities by establishing an EU BETTER Life coordination centre that will generate transferable tools and standards. At an intra-institutional level, the project creates local centres guided by a framework to follow the regional customization implementation. At an individual level, the regional centres develop capacities by training early career researchers and establishing a community of practice in each surrounding ecosystem. For that purpose, the centre is based on the quadruple helix model of innovation, where the interaction of academic, research, industry, government, and society generate mutually beneficial partnerships.The most outstanding outcomes of the project will be:•200+ early career researchers trained•14+ engagement managers trained•At least 10 standards for SER in Life Sciences•14+ consultation events with local stakeholders•40+ open source documents•6 open science publications•1 digital self-assessment tool for researchers•15+ training eventsIn a long term, the project will generate scientific impacts by designing transferable policies and tools, economic impacts by effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Community-based ICT for Maternal Healthcare in Africa', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

mHealth4Afrika is a collaborative research project that addresses maternal and newborn healthcare delivery, a key requirement of end-user communities in developing countries, and priority area in both the 2015 Millennium Development Goals and Post-2015 Sustainable Development Goals.Aligned with Horizon 2020 Societal Challenges, mHealth4Afrika will research and evaluate the potential impact of co-designing an open source, multilingual mHealth platform on the quality of community based maternal and newborn healthcare delivery in Southern Africa (Malawi, South Africa), East Africa (Kenya) and Horn of Africa (Ethiopia).Research and innovation actors from three European and four African countries will engage with local end-user communities (i.e. representatives of parents and local community leaders, Ministry of Health, healthcare professionals and volunteers, health oriented NGOs). Based on this User-centred Design, Living Labs, Collaborative Open Innovation based approach, the consortium will integrate and adapt· Multilingual electronic health records to store patient history, associated tests and test results;· Sensors to capture the results of a range of standardised tests for expectant and lactating mothers, unborn babies and infants;· Analytical and visualisation tools to facilitate the interpretation and monitoring of the patient results; and · Multi-lingual and multimodal mobile interfaces leveraging visualisation and speech synthesis to address literacy deficits and digitise data gathering through electronic forms.By focusing on accessibility, usability and integrated training, this will facilitate urban, rural and deep rural healthcare workers to adopt and use a comprehensive system that integrates quality community based healthcare delivery with telemedicine. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Correlations in complex systems' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

COCOS is a research project focused on important topics in a rapidly developing area of complex systems analysis and description. This particular field of interdisciplinary investigations originates from the methodology of theoretical physics which is a traditional subject of interest to the members of the Jagellonian University Complex Systems Research Centre. Members of the Centre have a long record of successful collaboration with other European research organisation carried out mostly during visits of Polish researchers to their European partners.The Centre now intends to become an internationally recognised unit, attractive to foreign senior researchers an offering temporary postdoctoral positions to graduates of European universities. The senior visitors and postdoctoral researchers should bring to the Centre new ideas and methods as well as the expertise on particular areas of study. The proposal includes study and modelling of natural and human-created networks, quantum information, soft matter and ecosystems.While these subjects appear to be inhomogeneous, they share common mathematical formalism and computational methods. Therefore, the feasibility of the project is well founded on the expertise of the Centre. Mathematical and computational tools needed to carry out the proposed research are strong points of the group, but as this Centre strives to maintain and further develop its high research profile, an influx of fresh ideas and instruction on newly developed techniques are required.Industrial applications of several systems studied at the Centre during the lifetime of this project appears feasible. By performing the tasks of this project, the Centre intends to induce cohesion in research with its European partners, improve its European-wide collaboration,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Neurosteroids: trophic and bevavioral effects' (1994-1998).

assistant: **Innovation**

To study the mechanisms by which neurosteroids increase the expression of specific myelin proteins.To test the beneficial effects of neurosteroids in transgenic animal models for hereditary peripheral neuropathies.To determine whether neurosteroids promote myelination in the central nervous system.To correlate performance in spatial memory tasks with neurosteroid levels in distinct brain regions.To explore the mechanisms by which neurosteroid - GABAA receptor interactions influence memory performance in rats and sleep patterns in rodents and humans.To study the effects of neurosteroids on different recombinant GABAA receptor subtypes and to define the neurosteroid binding site on the mammalian receptor protein. Neurosteroids are synthesized in the nervous system by glial cells. Recent research, carried out in the laboratories of the participants, has revealed 3 important effects of neurosteroids : they promote the formation of new myelin sheaths, improve spatial memory performance and modify sleep architecture. The mechanisms by which progesterone activates the transcription of specific myelin genes are explored. Transgenic animal models for hereditary peripheral neuropathies allow to test whether neurosteroids can reverse the process of demyelination, characteristic of these diseases. An important question is whether progesterone also promotes myelination by oligodendrocytes in the central nervous system. A particular isoform of the progesterone receptor is expressed in Schwann cells and in oligodendrocytes. The cloning of this new receptor may lead to the design of synthetic progesterone derivatives which would act selectively on the myelinating glial cells. Neurosteroids can influence memory processes. The relationship between their production in specific brain regio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An integrated assessment of recent evolutionary change  through genome wide mapping of regulatory changes and signatures of selection in natural sculpin (Cottus) hybrids' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

It is the unprecedented access to genome wide data that highlights the potential of current evolutionary studies and this proposal aims at exploiting this progress to analyze evolutionary processes in a well-established fish system of hybrid speciation. We study natural populations of freshwater fish referred to as sculpins (Cottus). In these we have identified species that have recently (<200 years) hybridized as a result of secondary contact through man-made canals between river systems. This gave rise to a new lineage with new adaptations that have allowed it to invade habitats that were not used by the parental species before. We are thus also dealing with evolutionary change that is associated with man-made ecological perturbations, the analysis of which is particularly timely. It is now possible to perform a near exhaustive search to identify genes and to study gene expression as a measure of evolutionary change in Cottus. A combination of genetic mapping experiments and screens for genotypic selection can reveal loci and functions as targets of selection in the adaptive evolution of invasive Cottus. This proposal specifically aims at identifying genomic traits such as copy number changes of coding sequences or changes in the gene regulatory architecture that have evolved as a direct consequence of hybridization and to explore their implication in adaptive evolution. The results will contribute to our understanding of the genetics of adaptation and the invasion of a new environment. With respect to hybrid zones and the evolution of new species, we will identify candidate genes and functions that can explain barriers to reproduction in the wild. Finally, we will be able to make significant progress with respect to the genetics associated with hybrid speciation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multiple stressor effects in the photobiology of Caribbeansymbiotic octocorals and its repercussion in the population fitness and reproductive output' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The ocean transformation due to direct or indirect human interference is a fact. Among the most threatened ecosystems are the so called “animal forests”. Animal forests are considered alive three-dimensional structures mostly (or completely) composed by hexacorals, octocorals, sponges, etc. In tropical seas, symbiotic octocorals (soft corals) are important part of these complex structures. Several synergic effects, acting as stressors in these organisms, have been detected, changing the distribution of species, the partial or total mortality patterns of populations and the associated to this three-dimensional structures biomass and biodiversity. Climate change is the main driver of these stressors, with a clear repercussion in the octocoral population fitness (bleaching events, physiological and metabolic adaptations, decrease in the gonadal output). The photobiology of the species (i.e. symbiont type and concentration, photosynthesis and respiration rates, variation in the photochemical efficiency, etc.) and its effects in front of climate change effects has been studied in hexacorals (hard corals), being the symbiotic octocorals largely neglected.  The aim of the project is to understand how futures scenarios of warming temperatures, ocean acidification and food changes will impact the photobiology and physiology of symbiotic octocoral population, reflected in the health status and reproductive capability of this group. Specific objectives of the project are: a) properly describe photo biological features in Caribbean selected symbiotic octocorals; b) Make exsitu experiments with different temperature, acidification and food availability testing metabolic and gonadal output response; c) Make in situ seasonal monitoring of the species biology and environmental factors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Benchtop nmr techniques for the structural characterization of foods' (BENCHNMR) targeting Fifth Framework.

assistant: **Abstract**

The Measurement Science Division in Unilever Research is faced with new challenges from the foods business. While the pressure to bring products to the market in a short time is increasing, the systems under investigation are becoming ever more complex both in structure as well as chemic composition. Whereas NMR spectroscopy is well established for studying complex meso- and microstructures of food systems, it is still considered as a technique that requires expensive instrumentation, trained operators and expert data interpreters. Therefore, Unilever has pioneered in relatively cheap and easy to handle NMR technology for non-(NMR) expert users such as food scientists, product developers, and operators in manufacturing who use this technique for process and quality control. Unilever has a proven track record in bringing such method to the end-users, and is actively pursuing this area. For the Marie Curie Industry Host Fellowships programme, we propose to develop a new generation of bench top NMR methodology (BENCHNMR) for the rapid meso- and microstructural characterization of complex food systems. There will be a strong emphasis on methods that deliver parameters that can directly be related to consumer related features. For this reason strong liaisons with the end-users will have to be built, most commonly through involvement in research and product innovation projects. BENCHNMR will be embedded in the academic and industrial research network that Unilever has built in this area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'antiProtonic Atom X-ray spectroscopy'.

assistant: **Objectives**

Numerous experimental observations have shown that the Standard Model is not complete. Precision measurements in quantum systems are one of the privileged frontiers for searching for new physics, as new particles may couple to atoms, provoking tiny changes in atomic structure that can be measured with state-of-the-art methods. Such searches are founded on an accurate understanding of quantum electrodynamics (QED), the field theory that describes the interaction between light and charged particles. While QED is well understood for light systems like the hydrogen atom where agreement between theory and experiment have been achieved up to third-order interactions with the quantum vacuum, for high-Z atoms in the strong Coulomb field regime, the theory remains untested beyond first-order interactions. This is due to both experimental complications, and theoretical uncertainties linked to unknown nuclear properties.  I propose a new approach for testing strong-field QED via the x-ray spectroscopy of antiprotonic atoms. In these systems, orders of magnitude higher Coulomb fields can be obtained, acting like a magnifying glass for QED effects that become easier to measure. Using transitions between Rydberg states, uncertainties from nuclear properties can be avoided and two orders of magnitude sensitivity can be gained with respect to the best current experiments, making testing strong-field QED finally possible for a broad range of atomic species.The realization of this project relies on the novel combination of two new technologies: slow antiproton beams at CERN, and quantum sensing x-ray detectors. The compatibility of these two requires new developments that will lead to a dedicated precision x-ray spectroscopy platform for antiprotonic atoms, with transverse applications b