RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Establishing services enhancing the innovation management capacity of SME´s in Hamburg and Schleswig-Holstein' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The four partners Investitionsbank Schleswig-Holstein (IB.SH), TuTech Innovation GmbH (TuTech), Wirtschaftsförderungund Technologietransfer Schleswig-Holstein (WTSH) and IFB Hamburg (IFB) are part of the Enterprise Europe Network(EEN) consortium in Hamburg and Schleswig-Holstein and established a well-known regional one-stop-shop for all EUrelated enquiries for SMEs and regional stakeholders.For the period 2019 core objective is to expand the client base and deepen the level of assistance by offering the service of “Key Account Management” (KAM) and “Enhancing SME Innovation Management Capacity” (EIMC). Aim is to faceexisting lack of innovation management capacity in small and medium sized companies (SME) and support their innovativeactivities in order to creating economic impact. The guiding principle is that the services are tailored to the needs of theidentified regional innovators and innovation systems.In this context the KAM is targeted at beneficiaries of the SME instrument, FTI and FET-Open under Horizon 2020, the EIMC addresses other highly innovative SMEs. The EIMC helps companies to establish effective innovation management systems that enhance the realisation of growth opportunities. The KAM focuses on those weaknesses which endanger the success of the funded project. It assists in finding specialised coaches and establishing a coach-client relationship. Both approaches aim to raise the company´s competitiveness and profitability.In the framework of the project the consortium acquired user licenses for the IMP3rove tool in order to assess gaps andneeds of the SMEs. In this context senior staff of the EEN attended training to ensure that the tool is used correctly and theassessment exercise complies with the envisaged EU standard. In addition the participatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'self-PoweRed cONductimeter for digiTalization of rapid mOlecular diagnostics'.

assistant: **Innovation**

Despite huge progress in prevention and treatment over the past century, infectious diseases still impose a great health burden. For this reason, lab-centralised immunoassays and nucleic acid tests that allow for specific pathogen identification with limits of detection reaching few copies per ml of sample are readily available and supported by both national and private health systems in the developed world. However, these tests are neither affordable nor accessible to patients in low- and medium-income countries. Fortunately, lateral flow antigen-based have proven to be a fast, reliable and affordable tool to detect a wide range of pathogens. However, such tests suffer from cross-reactivity with related bacterial or viral species and more importantly, they often require 10^5 pathogens per mL to yield a positive result. It becomes clear that there is a clinical and technological need to develop rapid tests that combines PCR sensitivity – able to detect one copy per mL - with LF affordability. PRONTO proposes a novel low cost, sustainable and self-powered readout system for nucleic acid detection based on conductimetry. The key component consists on a paper-based and single use self-powered conductimetric sensor developed during ERC Consolidator Grant SUPERCELL. The sensing approach is unique and minimalistic, as it breaks the classic paradigm sensor-electronics-battery as the sensor and the power source are merged into one element while making the detection system energetically autonomous. The simplicity of the approach will enable the deployment of highly sensitive and digital tests for infectious diseases at affordable prices and in a sustainable manner at a global scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineering Metal-Organic Framework-Polymer Binder Interfaces for Carbon Capture' (MOFBINDER).

assistant: **Innovation**

Reducing CO2 emissions urgently requires the deployment of large-scale carbon capture technologies, many of which are being developed using innovative materials like porous metal-organic frameworks (MOFs). However, MOFs are typically synthesized as small crystals or powders, making them unsuitable for adsorption systems due to the high-pressure drops caused by fine particles. To address this issue, MOFs must be shaped into larger particles using polymer binders. While studies have explored MOF materials combined with binders, no clear guidelines exist, and the design process is often based on trial and error.This project aims to develop a computational approach for designing MOF-binder composites with enhanced mechanical properties and controlled porosity. By utilizing parallel molecular simulations, we will predict the interface properties in a high-throughput manner. Machine learning techniques, drawing from both simulated and literature-mined data, will enable the development of a robust screening method. Additionally, our work will be integrated with the state-of-the-art Process-Informed design of tailor-made Sorbent Materials (PrISMa) platform, which connects material design, process optimization, techno-economics, and life-cycle assessment. This integration will allow for the evaluation and comparison of MOF formulations in terms of their greenhouse gas emissions throughout the lifecycle of the carbon capture plant, addressing one of the final steps in the deployment of carbon capture technologies.To achieve these goals, the Researcher will receive training in high-throughput atomistic simulation workflows, materials informatics, and machine learning for material discovery, along with a holistic engineering approach through PrISMa. Moreover, this project offers th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Content Delivery Improvement By Satellite' under Fifth Framework.

assistant: **Concept**

The objective of CODIS trial is to deploy and validate an original hybrid network dedicated to the improvement of multimedia content delivery. Indeed CODIS system will be composed of complementary DVB based satellite and terrestrial networks. The DVB-S processor of Stentor satellite will be used to set-up a fully meshed content delivery network, which aims at transporting and aggregating high volumes of multimedia content at the edge of the network.This network will be complemented by interactive access terrestrial networks relying on the DVB-T standard.To achieve this objective, innovative MPEG-4/7 based applications and MHP applications will be demonstrated, which will clearly prove the interest and the new forms of interactivity offered by these technologies. Thanks to qualitative as well as quantitative QoS measurements, CODIS consortium will demonstrate that the proposed network architecture complies with QoS requirements and can give full satisfaction to end users.Work description:The structure of CODIS project is split into three major phases.The first phase deals with the preparation of the CODIS trial. This phase, which will last 9 months, aims at specifying the complete CODIS network architecture as well as all the relevant segments and applications, including the DVB-S based satellite network, the two way DVB-T platforms, the MPEG-4/7 respective MHP based applications. It should be noted that each building block of the trial relies on existing or newly developed hardware or software. In parallel theoretical models for the QoS evaluation of the foreseen multimedia interactive applications will be proposed. The trial preparation phase shall end up by the definition of a deployment plan.The second phase of CODIS project handles the trial realisation and will las
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards a Unified Spatial Theory of Biodiversity' (SPATIODIVERSITY).

assistant: **Innovation**

One of the biggest and most persistent challenges in contemporary ecology is to explain the high diversity in ecological communities such as tropical forests, grasslands, coral reefs, or plankton ecosystems. The broad objective of our project is to understand the relative importance of processes and factors that govern the composition and dynamics of species-rich communities. Advances in this issue have important implications for efforts to protect terrestrial biodiversity from climate and land use change. Surprisingly, although most processes which are thought to contribute to species coexistence have a strong spatial component, the rich source of information on spatial patterns has not been used. To accomplish our goal, we take a radically different approach than previous attempts and adopt a spatially explicit perspective that will allow us to take significant steps towards a Unified Spatial Theory of Biodiversity. We use the best data sets available, i.e., 25-50 ha mega-plots of tropical forests each comprising several hundred of species and >100000 trees that are monitored and censuses every 5 years. We proceed in three steps. (1) We quantify the highly complex spatial structures found in these forests using state-of-the-art techniques in spatial pattern analysis. (2) We build a range of individual-based spatially-explicit simulation models ranging from  pure  neutral models to detailed process-based models of tropical forest, such as FORMIND. (3) We use pattern-oriented modelling to confront these simulation models with the set of patterns identified in (1) to identify the most parsimonious models that account simultaneously for all (spatial) patterns. We anticipate that the new spatial perspective and innovative computer modelling techniques will allow for a majo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The European Agroecology Living Lab and Research Infrastructure Network: Preparation phase' in the context of a Horizon 2020 call.

assistant: **Objectives**

Today, agricultural systems are facing multiple challenges, including climate change, loss of biodiversity, dwindling resources, degradation of soil and water quality. Agroecology can strengthen the sustainability and resilience of farming systems and thus contribute to addressing these challenges. Based on the premise that Open Innovation Arrangements (OIAs) and in particular Living Labs (LL) and Research Infrastructures (RIs) are instruments that have large potential to contribute to amplifying agroecology in Europe, the main aim of ALL-Ready (this project) is to prepare a framework for a future European network of LLs and RIs (to be called “AgroEcoLLNet”) that will enable the transition towards agroecology throughout Europe. It will rely on a highly participatory and inclusive approach and on experimentation in real life situations and thus itself uses a living lab approach. An underpinning principle of the project is strong stakeholder engagement, which has begun in the preparation of this proposal. The project has 3 phases: an initial preparatory phase in which the vision, scope and mission for the Network are defined and the criteria for inclusion in the Network of LLs and RIs as well as other forms of OIAs are defined. This will enable the mapping of current and emerging LLs, RIs and OIAs across Europe and their characteristics, highlighting best cases. In a second phase, different prerequisites/ activites for the future Network will be prepared ‘(sustainability, including funding, governance, capacity building, data and knowledge management). Plans for each of these will be constructed with stakeholders and then tested in a small-scale pilot network and then refined to match needs. Finally, the outcomes of the work will be communicated widely throughout Europe b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Designer enzymes featuring unnatural amino acids as catalytic residue' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Biocatalysis is a key component of the transition towards a more sustainable and “greener” chemistry. Surprisingly, natural enzymes use only a relatively small section of “reaction space”, that is, only limited number of reaction classes. This in marked contrast to the vast reaction space available to the synthetic chemist. Therefore, it is highly desirable to have enzymes available for the catalysis of these abiological reactions. With the advent of robust expanded genetic code methodologies, it is now feasible to introduce a wide variety of unnatural amino acids into proteins. We envision that the time has come to use this breakthrough technology to create enzymes that contain abiological reactive groups as catalytic residue, for the catalysis of reactions that are not possible using canonical amino acids only.The global aim of this project is the creation and application of designer enzymes with genetically encoded unnatural amino acids as catalytic residue for novel and new-to-nature catalysis.The following research objectives are key to achieving the overall aim:1. Achieving incorporation of unnatural amino acids containing organocatalytic side chains in proteins.2. Creation of a library of novel designer enzymes containing unnatural amino acids as catalytic residue.3. Application of these designer enzymes in catalysis of important reactions that have no equivalent in nature.4. Directed evolution of designer enzymes featuring unnatural amino acids as catalytic residue.5. Application of designer enzymes containing UAAs as catalytic residue in biocatalytic cascades.This highly ambitious project combines frontier chemical and biochemical research and will deliver completely new classes of enzymes that can access new and previously unexplored parts of biocatalytic “rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sensing Neuro-immune Activation in the Lung microenvironment' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The immune system is indispensable for our defense against infections, and plays an essential role in homeostasis, where compartmentalization and specialization are key aspects of every immune cell. Microenvironmental cues (e.g. stromal cell-derived signals) are integrated by the cell networks forming the immune system to maintain immune tolerance or promote immunity against an antigen. Recent findings suggest that neurons also contribute to curb the immune response; they produce neuropeptides that act directly on immune cells such as dendritic cells and neutrophils. However, our understanding of neuroimmune interactions is superficial: we ignore whether specialized cell subsets are responsible for integrating neural cues, we lack precision when studying these connections, and it is unknown whether neuroimmune exchanges are relevant in different tissues and immune reactions, as with the case of lung immune responses related to allergy and chronic obstructive disorders. Asthma has been shown to present a neurological component not yet entirely linked to the immune system. To gain insight into neuroimmune modulation, SIGNAL aims to elucidate the presence and function of neuro-sentinel innate lymphoid cells (nsILC) in the lung: ILC dedicated to detect and translate neuro-derived signals. ILC are tissue resident immune cells which are pivotal coordinators of immune homeostasis, bridging the innate and the adaptive immune system. Using a multidisciplinary approach by combining the selectiveness of optogenetics and chemogenetics with the unbiased power of detection of single cell genomics, and the comprehensiveness of mouse in vivo models, I have setup myself to discover and define nsILC in the context of type-2 responses in the lung. My work will develop our understanding of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Multi-omics Approach To Decode Epigenetic Lesions In Pancreatic Cancer Development' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Chromatin, the complex structured macromolecule consisting of DNA wrapped around histones, represents the ground where transcription factors, signalling pathways and mechanical stimulations converge to regulate gene expression and determine cellular phenotypes. Epigenetic mechanisms altering these phenotypes without modifying the DNA sequence are extremely pliable and allow for subtle and reversible changes in gene regulation. Consequently, aberrations in chromatin regulation are associated with a wide range of diseases, such as cancer, where they can be pivotal for the fitness and activity of malignant cells. Here we aim to investigate the role played by epigenetic mutations in pancreatic cancer, a dismal disease with poor prognosis and projected to be the second most common cause of cancer-related death in the next decade. The candidate will apply cutting-edge technologies such as parallel single-cell RNA-seq and single-nucleus ATAC-seq to uncover the correlation between changes in chromatin accessibility and gene expression in patient-derived and engineered 3D organoid models. These findings will constitute the basis for functional validations that will involve the combination of epigenomic tools (dCas9-mediated epigenetic modifications) and high-resolution imaging approaches (light-sheet microscopy). Therefore, this project will provide a comprehensive view of the epigenetic lesions occurring during cancer development, shedding light on mechanisms of gene de-regulation and paving the way to novel approaches to cancer treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unveiling the impacts of vapor pressure deficit on forest productivity' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Atmospheric dryness, which is often quantified as a vapor pressure deficit (VPD), exerts significant influences on vegetation productivity and global carbon cycles. VPD is expected to rise in a warming world, but how this increased atmospheric dryness will impact the carbon uptake by vegetation remains largely unknown. One major challenge is the lack of long-term measurements, which limits studies to the recent decades when satellite and flux measurements are available. Moreover, disentangling the effects of VPD from other highly correlated factors such as soil moisture is difficult. This lack of understanding hampers our ability to make skillful predictions of how future VPD changes induced by climate change will affect vegetation productivity globally.The VAPOR project seeks to address the existing knowledge gaps through a multi-timescale approach. First, the sensitivity of tree growth to VPD variations will be quantified on the decade-to-century timescale by leveraging global long-term tree-ring measurements as a proxy for forest productivity. Second, the independent effects of VPD and soil moisture on forest productivity during heatwaves will be disentangled using sub-diurnal high-resolution satellite observations from the last decades. Finally, output from global coupled climate simulations will be evaluated based on the insights from the previous findings, and emergent constraints will be applied to mitigate uncertainties in future projects of forest productivity based on relationships emerging from the multi-model ensemble and current observations. The constrained model results will then be used to evaluate the implications of future VPD changes on forest productivity and functioning. By embarking on this endeavor, I aim to deepen the understanding of the influen