RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative Acrylic(PMMA- Polymethyl methacrylate) Recycling Technology Complying with Regulations' (P2L) targeting Horizon 2020.

assistant: **Abstract**

P2L(Plant for 2nd Life), is a new generation technology for recycling polymethyl methacrylate(PMMA) wastes. This technology recycles PMMA to methyl methacrylate(MMA) monomer which in turn will be used for the production of PMMA sheets known as Acrylic or Plexiglas(TM).A plant to second life is the first step towards an endless cycle. MMA is the only plastic that can be eternally reincarnated, but only under the perfect technique. Our proposal provides this perfect technique and thus, it promotes sustainability.M-D2, a technopolis R&D company, developed a new pyrolysis technique for safe, cheap and eco-friendly recovery of MMA. P2L technology is not the only PMMA recycling technique, however it is the most eco-friendly, lowest power consuming one. Its product RMMA(regenerated MMA) has a purity more than 99%. These make P2L the future PMMA recycling technology for European Countries and many more developed countries complying the regulations.Making an innovative technology investment with high profit and fast return in a low competition sector is the unique selling point of P2L.PMMA is used in the production of TV screens, LED’s, automobile rear lights, aeroplane windows, mobile phone screens and many more in optical or surface/coating solutions. Wide usage(~3.36 M tons annually) of PMMA and the expects of 100% consumption increase in 15 years, results considerable waste production. PMMA wastes are collected and shipped to developing countries as China and India.Today a global crisis is on the way after China decided in 2017 to stop importing waste plastics. China started this waste ban in 01.01.2018. Conventional PMMA recycling techniques are restricted by regulations in the developed countries so it is a shocking threat stopping to export their waste PMMA. PMMA recovery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Low Cost Real-time Multi-Physics Virtual Reality Training System For In-vitro Fertilisation Microinjection Tasks' (CellTrainer).

assistant: **Innovation**

The ability to operate on cells is a fundamental capability when developing novel cell based therapies. In this context, the skills needed to manually inspect, prepare and modify cells in-vitro with repeatable micro-nano precision are essential; enabling the creation of new biomedical solutions to fight disease more effectively. Highlighted by the Innovate UK Cell Therapy Catapult, the market opportunity for improved micromanipulation techniques is valued to be >€4.5billion in 2017 and applicable to a wide range of fields from biotechnology, pharmacology to embryology. To realise this opportunity, it is vital to have a well-trained workforce capable of performing repeatable high precision manipulations at a cellular level.  However, current training techniques are laborious, vary in quality, and do not take advantage of the inexpensive technologies available today that can improve the expertise of the clinical operators without the need for expensive learning facilities. To address these unmet needs, we present CellTrainer, a virtual reality simulation based training system. Based on the empirical data and biomechanical models gained through our novel micro/nano telehaptic systems that were developed as part of our ERC-AdG grant, in this ERC-PoC project we propose to develop a real-time Virtual Reality (VR) physics engine to simulate different micro/nano training environments and objectively monitor user performance whilst providing clinical learning feedback. In collaboration with spin out company Yantric, UCL Business and identified first customers, we will conduct the necessary commercial activities to translate CellTrainer into the real world. At first, we envisage CellTrainer to be an indispensable tool in reducing the time needed to train up expert clinical users
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Production and Presentation Environment using Agents for building Information Channels' in the context of a Fifth Framework call.

assistant: **Objectives**

PEACH aims to develop an editorial system for the development, production and provision of personalized information channels. Opposed to conventional editorial systems, the system shall cover the complete publishing value chain, from offering pro-active information acquisition functionality for editors by using agent based information retrieval techniques, to customer-oriented personalised content packaging and delivery, including support for different business models (e.g. integration of ads, pay-per-vie models etc.).The targeted application should be flexible according to underlying business processes and applied business model for placing the information channels in the market. PEACH aims to develop business models for information channels, supporting commercial exploitation of information services.Work description:In the first phase of the project, findings obtained during the preliminary phase pilot called PAIR (IE-8041) will be updated. Based on the resulting user requirements towards information channels, business models for commercial information channels will be developed. Facing the need to integrate already implemented functionality of products of vendors participating the PEACH project an object-oriented bus structure will be designed.This bus structure will rely on object technologies as COM/DCOM or CORBA. Standardised document structures will be outlined for the content repositories, with regard to business models, intellectual property right issues and information retrieval aspects. For the development, the developer can use the development framework that is used. Together with the participating content providers the core PEACH application will be implemented and installed according to their requirements. After that the content provider will start to deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Structure-function relationship in plant plasma membrane proton pumps'.

assistant: **Innovation**

Plant plasma membrane proton pumps (H+-ATPases) have a primary role in the coupling of metabolic energy to solute transport. The objective of the consortium is the understanding of how the structure of these pumps is related to their function. Plasma membrane H+-ATPases are not related to intracellular H+-ATPases such as FoFl type ATPases and vacuolar ATPases. They belong to the P-type ATPase family which among others includes the plasma membrane Na+/K+-, H+/K+- and Ca2+-ATPases of animals. So far, no Ptype ATPase structure has been solved. Thus, structural information on any P-type ATPase will be a breakthrough in understanding how these cation pumps carry out transport. It will be a major aim to produce 2D and 3D crystals of purified plant plasma membrane H+-ATPase (Task 1). The structure of a 113 amino acid peptide comprising the Cterminal regulatory domain of the H+-ATPase will be solved separately by X-ray diffraction analysis of 3D crystals (Task 2). The information gained from obtaining the structure will be complemented by a search for individual amino acids important for H+-ATPase function (Task 3). The consortium brought together in this proposal is in a good position to realise these tasks because 1) an expression system allowing production of a single, homogenous and functional plant H+-ATPase has already been developed; 2) an in-vivo selection system for improved H+-ATPase activity is available; 3) the problem of structure determination of membrane proteins is circumvented by combining 2D and 3D crystallization, and 4) several P-type ATPases have already yielded 2D crystals, one of them by one of the partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Impact of Biogenic versus Anthropogenic emissions on Clouds and Climate: towards a Holistic UnderStanding', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Clouds are a very important, yet not well understood feedback factor in climate change and they contribute to the effective radiative forcing (ERF) from aerosol-cloud interactions (ACI). The uncertainty in ERFaci is larger than for any other forcing agent. Also, feedbacks between the terrestrial and marine biosphere and the atmosphere involving ACI are thought to play an important role in regulating climate change but their relevance remains poorly quantified.BACCHUS proposes to quantify key processes and feedbacks controlling ACI, by combining advanced measurements of cloud and aerosol properties with state-of-the-art numerical modelling. The analysis of contrasting environments will be the guiding strategy for BACCHUS. We will investigate the importance of biogenic versus anthropogenic emissions for ACI in regions that are key regulators of Earth's climate (Amazonian rain forest) or are regarded as tipping elements in the climate system (Arctic).BACCHUS will generate a unique database linking long-term observations and field campaign data of aerosol, cloud condensation and ice nuclei and cloud microphysical properties; this will enable a better quantification of the natural aerosol concentrations and the anthropogenic aerosol effect. BACCHUS will advance the understanding of biosphere aerosol-cloud-climate feedbacks that occur via emission and transformation of biogenic volatile organic compounds, primary biological aerosols, secondary organic aerosols and dust. Integration of new fundamental understanding gained in BACCHUS in Earth Systems Models allows to reduce the uncertainty in future climate projections. This will have a direct impact on decision-making addressing climate change adaptation and mitigation. BACCHUS brings together a critical mass of experimentalis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Understanding the Importance of the Melanocortin 3 Receptor in Muscle Mass Accrual and Body Composition' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

We are yet to understand how the body regulates muscle mass in response to nutrient sensing at a whole organism level. The loss of muscle mass occurs in a range of diseases, including cancer cachexia, in which mortality risk is substantially increased by muscle wasting. The melanocortin signalling system in the hypothalamus is a crucial node in energy and nutrient sensing, with growing evidence implicating the understudied melanocortin 3 receptor (MC3R) in the control of body composition and lean mass. To date, the influence of MC3R tone on muscle mass has only been studied in mice and humans lacking MC3R from conception. To understand MC3R action and the spatial and temporal relevance of the receptor in regulating muscle mass, using in vivo and ex vivo approaches, IMMAc will:7.Determine the neuroendocrine effects of MC3R activity8.Assess the role of a putatively critical MC3R sub-population in controlling body composition and muscle mass9.Determine the importance of MC3R for muscle mass in a mature organism and the extent to which MC3R tone can be manipulated to therapeutically alter muscle mass in adulthoodNeuroendocrine impacts of MC3R activation will be examined using ex vivo hypothalamic culture and in vivo. Neuron-specific deletion of MC3R will allow mechanistic understanding of MC3R action, and the physiological and functional consequences of MC3R activation on skeletal muscle will be assessed by examining physical activity and fibre functionality.IMMAc will provide understanding of mechanisms underlying control of muscle mass and body composition by a key central nervous system receptor. Moreover, this project will reveal the relevance of MC3R for muscle mass in adult life and explore the therapeutic potential of manipulating MC3R to address the global health ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Imaging Innate Immunity of Staphylococcal Infections' under Seventh Framework.

assistant: **Concept**

Staphylococcus aureus community-acquired (CA)-MRSA strains are highly virulent and can cause infections in otherwise healthy individuals and are a leading cause of death worldwide. Innate immunity is our primary defense against invading staphylococci. Blood-neutrophils migrate to the site of infection where they, in concert with the complement system, engulf and kill bacteria in a process called phagocytosis. Especially CA-MRSA strains seem to be very efficient in circumventing this neutrophil killing. Interestingly, only a relative small number of virulence factors have been associated with CA-MRSA, one of which are the phenol soluble modulins (PSMs). In vivo models of experimental infection with PSM-mutants have shown a critical role for PSMs in skin and soft tissue infections. PSMs are small alpha-helical peptides which have two distinct functions on the immune system, in vitro PSMs can attract neutrophils in the nanomolar range, whereas in the micromolar range they are cytolytic for neutrophils. Recent publications suggests that these two functions complement each other for full staphylococcal virulence, although it seems counter-intuitive for S. aureus to actively attract its mortal enemy: the neutrophil. To make matters even more complicated PSMs are functionally inactivated by host serum lipoproteins, most efficiently by high density lipoprotein (HDL). The goal of this research proposal is to determine the mechanism of action for PSMs in staphylococcal disease. To this end, I will use genomic and proteomic approaches combined with cutting edge in vivo spinning-disk confocal microscopy, to dissect the functions of PSMs in host-staphylococcal interactions in; 1) neutrophil recruitment, 2) neutrophil lysis 3) HDL neutralization and liver pathology, 4) Evasion of PSM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'reliAble euRopean Identity EcoSystem'.

assistant: **Objectives**

ARIES main goal is to deliver a comprehensive framework for reliable e-identity ecosystem comprising new technologies, processes and security features that ensure highest levels of quality in eID based on trustworthy security documents and biometrics for highly secure and privacy-respecting physical and virtual identity management, with the specific aim to tangibly achieve a reduction in levels of identity theft, fraud and associated crimes. The set of solutions will be designed to achieve required levels of multi-party trust with efficiency, ease of adoption and convenience for all end-users (citizens, law enforcement, businesses), consolidating Europe as world leader in enhanced identity-based services as a basis to boost the competitiveness of its economy. ARIES will leverage virtual and mobile IDs cryptographically derived from strong eID documents in order to prevent identity theft and related crimes in the physical (e.g. an airport) and virtual (e.g eCommerce) domains. Both, the derivation process, and the derived IDs will be univocally linked to citizens' biometric features, increasing the level of identity assurance during the credential issuance process and during authentication. Highest data protection standards will be followed to provide digital privacy-preserving features. Thus, the project will provide a global approach for ID Ecosystem in Europe to address European-specific concerns to improve identity, trust and security, and better support the law enforcement to address the new threats in cybersecurity while achieving far-reaching socio-economic positive impacts.ARIES will demonstrate its outcomes and the levels of identity prevention reduction achieved in two use case demonstrators (secure eCommerce and identity virtualization for secure travel), cover
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Guide Stars Adaptive Optics for Retinal Imaging' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Guide Stars Adaptive Optics for Retinal Imaging (GSAORI) project aims at developing new imaging techniques in the field of ophthalmology. As the eye presents time-variable aberrations, an Adaptive Optics (AO) loop greatly enhances quality and resolution of retinal imaging, enabling the examination of structures such as cone and rod photoreceptors and leukocytes in vivo in a non invasive way and at a microscopic scale.Although AO has enabled outstanding progresses in ophthalmology, it has its limitation. The pupil motion and tear film thickness changes during the examination can limit the performance of the AO system. Also, the distortions of the retinal structure influence the wave-front analysis. Finally motion artefacts can have a strong impact on the correction capacity of the AO system. Therefore satisfactory image quality can only be achieved in carefully selected patients, which currently prevents a widespread use of this technology.The overall objective of the project is to overcome these limitations by developing systems that are more robust to retinal distortions and local media opacities. This will enable acceptable image quality in the majority of patients. The emergence of versatile AO systems would be a significant milestone towards making this technique a routine for eye examination.To achieve this goal, we propose to use guide stars that are spread over different locations of the retina to minimize the influence of eye’s defects on the wave-front measurements. This technique is directly inspired from astronomical telescopes where several laser guide stars are used as references to provide efficient wave-front correction on a large field of view. Following the conception of a system with guide stars, new algorithms for wave-front sensing and control wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The behaviour of high technology metals during water-rock interaction; natural occurences and experimental investigation' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Technological breakthroughs are providing new uses for the high technology metals that will eventually deplete existing reserves and create a need to find additional resources. Until recently, hitech metals were considered immobile during hydrothermal fluid-rock interaction. Although we now know that the contrary is true, little is known of the nature of hydrothermal fluids in such settings. Similarly, there are no published experimental data pertaining to the manner in which these metals are dissolved in hydrothermal solutions.  This application seeks funds to investigate the behaviour of hi-tech metals in hydrothermal systems and determine the conditions under which they are hydrothermally concentrated. A multidisciplinary approach is proposed to take place within the Mineralogy and Geochemistry Teams of the U.P.S., Toulouse.  The Tamazeght complex, Morocco, has been selected for detailed study. Petrological and geochemical approaches will be used to establish the composition of the fluids responsible for metal transport and the physico-chemical conditions of their deposition. A program of solubility experiments has been designed to investigate the speciation of Zr in F-bearing aqueous solutions at up to 350rC.  The results of the above studies used in conjunction with computer modelling and geological reasoning, will aid developing a plausible quantitative models for the genesis of this poorly understood but increasingly important class of mineral deposits.