RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New Foundations for Intensionality' (2021-2027).

assistant: **Concept**

Intensional notions such as those of property, content, proof, possibility and necessity are central to philosophy, logic, mathematics and linguistics. However, these notions are threatened by paradoxes reminiscent of those that plagued the foundations of mathematics at the beginning of the XX century. And while a consensus has emerged over which shape a foundation of mathematics should take, the intensional paradoxes are still awaiting solution. Indeed, the intensional paradoxes affect the major theories of content that in recent years have brought about what has been hailed as a hyperintensional revolution, with many applications in philosophy and linguistics.The GOOD INTENSIONS project aims to provide new philosophical, semantical and logical foundations for intensional notions, which will deliver a comprehensive and uniform solution to the intensional paradoxes. To achieve this, GOOD INTENSIONS will develop a fundamentally new approach to intensionality based on three ground-breaking ideas: a general, function-first approach to intensional talk, focused on its expressive role; a new, proof-theoretic approach to the semantics of intensional vocabulary; an original approach to the intensional paradoxes based on the use of intensional vocabulary in hypothetical contexts.The resulting new approach to intensionality will be used to develop new theories and logics of properties, content, proof and modality which are philosophically and linguistically motivated, paradox-free and logically strong. As a proof of concept for the new approach to intensionality, the new theories and logics will be applied to central philosophical questions, such as the question of whether the mind is a machine and the question of realism about properties. Based at the ILLC and advised by an int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Flame Retardant ON Textile' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The aim of the research is to develop and produce flame retardant textile, with economical and environmental advantages. Once project will be completed, it will be possible to increase the flame retardant textile market quota to the detriment of untreated textiles. This could support the introduction of new standards and rules to grant a higher security level against fires.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Lngs: a low background facility for particle physics, astrophysics, nuclear physics, geophysics and biology.'.

assistant: **Concept**

Description:The Laboratori Nazionali del Gran Sasso is located in Abruzzo (Italy), 120 km east of Roma. The underground infrastructure was build in the 80's under the GranSasso Mountain. 1400 meters of calcar rocks are shielding the lab from the cosmic rays, so that the natural radioactivity level is highly reduced. With about 18000 square meters of underground area, it is the largest underground lab in the world completely devoted to fundamental research.The easy access and the thickness and low level of radioactivity of the rock make LNGS an outstanding facility for experiments requiring a low background environment and shielding from cosmic radiation. Users can work with the scientific and technical support of LNGS staff of the Research and Technical divisions. The facilities of the Underground Laboratory available for TARI users include: Infrastructures for low background measurements; instrumentation for radon monitoring and geophysics; cryogenic facilities; one accelerator facility for low energy nuclear physics; computing infrastructures and PC arrays. Additional facilities are available for users in the external buildings and include offices, workshops (chemical, electronic and mechanical), computing center, library and canteen.Application:Eligible researchers (home institution in EU member states or associated countries) wishing to have access to the LNGS facilities are required to submit to the LNGS written proposals describing the work that they wish to carry out, and other information as requested in the application form. The application form can be downloaded from the LNGS web site (www.lngs.infn.it link European Community Fundings); it must be sent by ordinary mail to the following address: Transnational Access to Research Infrastructure (TARI), INFN Lab.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Aromatic Foldamer Mimics of B-DNA: Targeting the Alpha-Helix' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Protein-nucleic acid interactions (PNIs) play a central role in biology and their control would enable long-desired biological interventions and future therapeutic applications. However, synthetic molecules that reproduce the overall shape and surface features of nucleic acids to interfere with PNIs have been lacking because, up to now, it has not been possible to design such extended and complex abiotic interactions interfaces. Due to their distinct chemical composition, predictable shapes, large size and conformational stability, aromatic oligoamide foldamers (AOFs) are prime candidates for breaking new ground in this field. FOLOF aims to develop AOF-based surface mimics of the B-DNA double helix targeted to the large ensemble of sequence-selective PNIs mediated by alpha-helices.Based on the PIs expertise in AOF science, FOLOF will proceed by 1) expanding the chemistry tool box to enable specific design objectives; 2) optimizing the automation of AOF synthesis for the fast delivery of long sequences; 3) identifying structural features of protein-foldamer complexes and specific foldamer features that make them outcompete DNA binding; 4) establishing protocols to iteratively improve protein binding affinity and selectivity for AOFs, and AOF-DNA covalent hybrids; and 5) developing computational tools for ab initio AOF-based DNA mimic design. Through a strategic combination of chemical synthesis, computational predictions, crystallographic structural analysis, binding studies, and screening tools, FOLOF will push the production of abiotic molecular mimics of nucleic acids to a completely new ensemble.


**Keywords:** foldamers, molecular recognition, alpha-helices, protein surface recognition, molecular design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deconstructing and Rewiring RNA-RBP regulatory networks' (RBP-ReguNet).

assistant: **Innovation**

RNA-binding proteins (RBPs) are critical regulators of gene expression programs. They regulate all aspects of RNA life, including transcription, splicing, modification, localization, stability, translation and decay, and consequently, perturbations in these RBP-RNA networks underlie the origin of many diseases. Recent proteomics-based studies have vastly expanded the repertoire of RBPs to the thousands, uncovering unconventional RBPs such as metabolic enzymes ‘moonlighting’ in RNA-binding activity or RNAs “riboregulating” protein function. This represents a much broader layer of biological control that was previously envisaged, which adds an entirely new dimension to RBP-dependent regulation of cellular homeostasis. RBP-ReguNet has been conceived to leverage these new discoveries to identify druggable targets for a range of untreatable diseases, including cancer, neurological disorders, liver diseases and infectious disease. Our ambition in RBP-ReguNet is to create a high-level training program based on basic research but with a strong impact on clinical translation. RBP-ReguNet will provide advanced multidisciplinary scientific training that spans from computational, structural, molecular and cellular biology to medicinal chemistry and pharmacological screening, to the next generation of European researchers in an intersectoral environment to pursue ambitious and high gain research on the development of new therapies based on RBP biology. They will be trained in a range of core and state-of-the-art discipline-specific research skills, complementary transferable skills, and entrepreneurial skills by secondments to non-academic partners, with a common focus to discover actionable targets. This network of excellence will push the boundaries of knowledge in the protein-RNA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structuring free-electron wave functions through interaction with structured light and engineered metamaterials' (STRELIM), addressing dissemination and exploitation.

assistant: **Impact**

Controlling free-electron wave functions with light has recently emerged as a powerful approach to gaining unprecedented space-time resolution in imaging and manipulating the nanoworld. However, control over the electron wave function has so far been limited to specific low-dimensional spaces, such as the transverse plane, the temporal profile, or the energy distribution. In contrast, accessing multiple dimensions simultaneously remains a complex challenge, which I intend to tackle through this project. The first goal of my project is to search for exotic structures of quantum free-electron waves in high dimensions, exhibiting topological textures and defects beyond a simple vortex. To this end, I will draw inspiration from optical waves to create structured quantum waves that are free-electron solutions of the Dirac equation. In a second goal, I aim to explore the control of free-electron wave functions based on the interaction with structured light to unveil new capabilities enabled by recent advances in spatial or spatiotemporal light shaping, which can, in turn, produce previously inaccessible electron waves. In a third goal, I will explore the use of photonic metamaterials to control free-electron wave functions, capitalizing on an enlarged set of degrees of freedom in the design of metamaterial and the subsequent control of optical fields, which is expected to translate into an enhanced ability to manipulate electron wave functions in spatial, temporal, or spatiotemporal domains. This study should expand the current boundaries of free-electron science and technology through a multidisciplinary approach, pushing beyond current capabilities to unprecedented limits of spatiotemporal resolution, impacting the design of more compact and versatile electron sources (e.g.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sensor development for routine prediction of metal biouptake in freshwaters and soil solutions' in the context of a Fifth Framework call.

assistant: **Objectives**

In collaboration with end-users, we will compare sensors for routine prediction of metal bio uptake based on in site metal speciation measurements. We address aims of Water Quality Directive 2000/60/EC to protect aquatic systems by setting environmental quality standards. Our results will aid implementation of this policy by formulation of appropriate speciation based parameters for heavy metals (Cu, Pb, Cd, Zn, Ni) and by provision of the tools to enable their routine measurement by end-users.Specifically, we will:(i) determine simple predictive quantitative parameters for assessing metal biouptake(ii) rigorously compare several dynamic speciation techniques (iii) assess the relative merits of the techniques in the field( iv) assess the capabilities of the techniques to predict metal uptake by organisms under a range of natural conditions(v) apply the sensors and models to routine monitoring at the river basin level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Software Platform for Multiscale Modelling of Reactive Materials and Processes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Reactive process design has largely been based on trial-and-error experimentation and similarly, reactor design has utilised empirical kinetics (data-based models). On the other hand, physics-based modelling approaches are emerging as highly promising in the development of new catalytic materials and reactive processes, and it would be desirable to be able to use high-fidelity, first-principles-based reactor scale simulations for process design. Multi-equation models are steadily gaining ground in the chemical reaction engineering community, combining mature tools at each scale, from the molecular up to the reactor. However, such efforts are currently restricted to academia; a commercial modelling suite and software platform, accessible to the generalist user, is lacking.  To address this challenge, ReaxPro has identified a set of academic software tools (EON, Zacros, CatalyticFOAM) which will be upscaled into easy-to-learn, user friendly, interoperable software that is supported and well documented. These tools will be further integrated with commercial software (ADF Modeling Suite) into an industry-ready solution for catalytic material and process design. The ReaxPro Software platform and associated services will be made available via the European Materials Modelling Marketplace through the consortium's partnership with ongoing EU projects MARKETPLACE and VIMMP. To fully reach the target technology readiness level of 7, ReaxPro has partnered with translators and industry for validation and demonstration in pilot- and industrial-scale user cases. As a result of the proposed activities, academia and industry will have at their disposal an integrated, interoperable, customisable and modular modelling platform, enabling users to gain unique fundamental insight on reactive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reconciling Europe with its Citizens through Democracy and Rule of Law' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

RECONNECT starts from the observation that the European Union (EU) and the Member States are confronted with an existential crisis of the entire European project. As a result of several successive crises an increasingly large share of the population perceives the EU as an undemocratic and unjust political system. Overall trust in institutions at both Union and Member State levels is waning, while ever louder calls for a repatriation of powers to the national level are shaking the EU to its core. Against this background, our underlying assumption is that the deeply diverse and pluralistic Union of today needs to be more firmly rooted in justice and solidarity in order to be sustainable. Our working hypothesis is that European governance can regain authority and legitimacy through democracy and the rule of law, provided citizens’ aspirations and preferences are duly taken into account. This will allow for a renewed trust and recognition of the EU as a policy-provider that acts with a view to genuinely establishing a “society in which … justice [and] solidarity … prevail”, as Art. 2 TEU requires. With a unique multidisciplinary consortium of researchers, we analyse the existential challenges to the EU’s authority and legitimacy, through a comprehensive examination of principles, practices, and perceptions of democracy and the rule of law in the EU. Our end-user approach enables us to point to how democratic and rule of law principles and practices of institutions resonate with the actual aspirations, perceptions and preferences of citizens. Our ultimate objective is to contribute to a new comprehensive narrative for Europe that “reconnects” European governance with citizens. By means of an effective impact and dissemination strategy and through tailor-made policy recommend
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Removing of biogenic amines of the wine by selective adsorption on functionalized porous solids' (2014-2020).

assistant: **Concept**

The presence of biogenic amines (BA) (histamine, putrescine, cadaverine, etc) is usual in fermented beverages such as wine. Due to the toxicity of these BA, some countries have established recommendations concerning the maximum levels allowed in wines. Taking account the difficulty of controlling the production of BA during winemaking, the removal of them from finished wines avoiding the modification of the chemical composition related with the wine quality is a great challenge considering the complexity of the wine chemical composition and its organoleptic characteristics. This multidisciplinary project (AMINE_REMOVAL) presents an innovative approach based on the design of functionalized mesoporous materials (according with the size of biogenic amines) with specific functional groups on the surface to remove selectively biogenic amines from wine with a minimum effect on its organoleptic characteristics. This project includes the synthesis of materials, a deep study of the effects of the materials in synthetic and real wines at chemical and sensorial level, and the application to real wines in a pilot-scale plant. AMINE_REMOVAL represents an important step in the strategy to tackle the problem of the presence of biogenic amines in wine. Thus, obtaining a suitable method to remove the amines from wines will have a great impact not only on the quality of the wines, but also on the possibility to establish a maximum concentration of biogenic amines in wines by the European Union in its food security policies in order to protect the consumer. This project fits in one of the society challenges of the European 2020 strategies (food safety and quality, productive and sustainable farming, sustainability of natural resources, marine and maritime research).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Predictions and Actions shape sensory plasticity'.

assistant: **Innovation**

The ease with which children acquire new skills is progressively lost with age. Several mechanisms make the adult brain resistant to change, especially for low-level sensory processing, the hardest barrier for strategies aimed at recovering plasticity. PredActive will use vision as a test case to develop a new understanding of plasticity and its limits, through an emerging theory of brain function termed predictive coding. This theory asserts that not all incoming information is encoded directly, but only deviations from a priori predictions are represented. It follows that keeping predictions updated and calibrated to the sensory input is crucial for accurate processing. I propose that calibrating the prediction-verification cycle involves transient plasticity, of the type elicited in adults by interference with sensory input. For example, briefly patching one eye leads to a sustained boost of sensitivity and BOLD responses for that eye. This is usually interpreted as a homeostatic response. But predictive coding suggests another interpretation: when a sensory channel consistently fails to respond as expected, its signals are no longer predictable, and therefore generate large prediction errors that explain the short-term boost. A strong implication is that this form of plasticity should be elicited, even without sensory deprivation, by manipulating sensory predictability. Preliminary studies by the PI suggest that this is the case. PredActive will establish this principle and uncover its neural underpinnings by manipulating different sources of predictions (through advanced psychophysics and virtual reality) and tracing their origin (with ultra-high field fMRI, in adult volunteers and patients). The studies will permit a novel understanding of predictive sensory proce