RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Understanding seaweed submergence tolerance mechanisms and translating them into land plants'.

assistant: **Innovation**

Global food security is threatened by climate change, particularly increased incidences of flooding and drought. Flooding has catastrophic impact on agricultural productivity, as most agricultural crops are sensitive to waterlogging and submergence. Flooding is a complex, multi-factorial stress involving lack of oxygen, followed by oxidative stress as the flood subsides and sometimes accompanied by changes in salinity. The molecular strategies land plants use to respond to submergence vary widely between species and are not fully understood due to lack of model organisms naturally adapted to such multiple stresses. SUBTOL takes a completely new approach to improving plant submergence tolerance: harnessing genetic mechanisms from green seaweeds, a group of organisms naturally adapted to both submergence and desiccation, for which there is no equivalent terrestrial counterpart. SUBTOL will use the emerging model green seaweed Ulva to understand the changes in gene regulation that occur during seaweed submergence and exposure. Ulva shares a common ancestor with land plants and is uniquely adapted to natural periodic submergence/exposure cycles arising from tides. SUBTOL sets a new research paradigm and will define for the first time the molecular mechanisms regulating both submergence and post-submergence stress in a seaweed. This data will then be used to manipulate relevant genes in land plants, to modify their submergence tolerance via a synthetic biology approach. SUBTOL will thus generate knowledge benefiting both academia and industry. SUBTOL (i) initiates a step-change in the societal value of seaweeds by using them as models to understand adaptive processes largely absent from land plants, (ii) greatly improves understanding of both seaweed physiology and plant str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Genome instability and radio-induced mutagenesis in germ cells: consequences in the descendants'.

assistant: **Concept**

It is with great pleasure that I write this letter of recommendation on behalf of Dr Laurent MICCOLI. I am familiar with Dr MICCOLI's work from the period in which Laurent MICCOLI prepared his PhD thesis at the CURIE Institute and the work he performed during his postdoctoral appointment in my department. Dr Laurent MICCOLI has realised a remarkable work in purifying a human protein potentially involved in illegitimate recombination and in the mutagenesis induced by physical and chemical carcinogens. The mechanisms of mutagenesis in cancer and more generally in biological evolution began to be identified and characterised in mammalian cells. The results obtained by Dr MICCOLI and the other researchers of the Laboratory of Genetics of Radiosensitivity demonstrate the capacity of this protein to directly interact with DNA, probably during the process of replication. Dr MICCOLI is a young researcher that succeeded in performing a straightforward, technically innovative and original research. He is creative, enthusiastic and has a great capacity of work. Dr MICCOLI knows well the techniques of molecular biology. The obtained results allowed him to contribute to numerous articles. The attribution of one year postdoctoral fellowship to Dr MICCOLI will allow him to get trained in order for starting a new research approach. Indeed, Dr MICCOLI has the intention to characterise the mechanism responsible for the hereditary transmission of genetic instability induced by ionising radiation. An introduction to this domain during a post-doctoral training course in a leader laboratory marks the beginning of a long-term joint search effort in an original and prioritary field for the CEA. I highly support his scientific approach and his intention to become researcher at the CEA. Indeed,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'BACterial Hosts for production of Bioactive phenolics from bERRY fruits'.

assistant: **Innovation**

Plants synthesize a staggering variety of secondary metabolites, and this chemodiversity is a poorly used pool of natural molecules with bioactive properties of importance for applications in the pharma and food industries. BacHBerry focusses on phenolic compounds, a large and diverse class of plant metabolites, which are currently in the spotlight due to their claimed beneficial effects in prevention and treatment of chronic diseases, but that also have applications as cosmetics, flavours and food colorants etc. Berries are soft and colourful fruits, with great diversity, high content and unique profiles in phenolic compounds, making them a major source of these high-value metabolites. The BacHBerry project aims to develop a portfolio of sustainable methodologies to mine the potential of the untapped biodiversity of the bioactive phenolic compounds in an extensive collection of berry species. Full exploitation of this unrivalled natural resource requires an integrated and comprehensive effort from bioprospecting in berries using SMART high-throughput screens for the valorisation of phenolic bioactivities aligned with their identification using cutting edge analytics and subsequent elucidation of their biosynthetic pathways. This knowledge will facilitate metabolic engineering of suitable bacterial hosts for high-value phenolics production in scalable fermentation bioprocesses, ultimately serving as commercial production platforms. The consortium comprises a full chain of research and innovation, with 12 research groups, 5 SMEs and a large enterprise, representing 10 countries including partners from ICPC countries Russia, Chile and China, with the capacity to exploit novel bioactivities from berry fruits diversity. BacHBerry develops a pipeline of sustainable and cost-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The physics of quantum information' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Young researchers will be trained in the research establishments of leading communication and computation. Quantum superposition and quantum European scientists in quantum optics and quantum information entanglement can make communication absolutely secure and can increase Dissemination of expertise to young scientists will be achieved by personal computational power beyond the reach of any classical computer. Theoretical training on the job, as well as at workshops and conferences of the and experimental teams in the network will collaborate to develop new network methods and algorithms as well as experimental realizations in quantum cryptography, quantum communication, and quantum computation. The network will jointly develop the hardware and software, and define the security criteria for a full quantum cryptography system. The teams in the network will analyse and experimentally test schemes of quantum communication, studying quantum effects in data coding and transmission. Experimental realizations of quantum logic gates will be building. A comprehensive feasibility study of quantum computation will include decoherence and dissipation, noise reduction and correction, and new quantum algorithms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional study of sox9 protein role in vertebrates sex determination and chondrogenic differentiation' (1994-1998).

assistant: **Innovation**

Research objectives and content In mammals, and probably in all vertebrates, the transcription factor SOX9 is developmentally bi-potential: it has a crucial role in chondrogenesis and a central involvement in testis determination. The SOX9 gene was cloned in 1994 as the gene responsible for a severe syndrome affecting cartilage formation (Compomelic Dysplasia) generally accompanied by sex reversal. In this project, by functional interactions study of SOX9 with other transcription factor, or in homomere complexes, I propose to investigate the molecular processes governing the SOX9 protein action in chondrogenic events or in sexual differentiation. This project has three fundamental components: - the cloning and the characterisation of genes involved in male sex determination and regulated by both SOX9 and SF1 (another transcription factor involved in sex determination which interact with SOX9). - the functional study of the physiological significance of SOX9 self-association and the implication of this homo dimer in chondrogenic-specific gene regulation. - the research of interacting protein that could be involved in regulation of the transcriptional capacity of the SOX9 protein, or interact with SOX9 in a signal transduction pathway, by using SOX9 in a two hybrid screen. Training content (objective, benefit and expected impact) Because I will apply for a research position in France for the study of the sex determination process, after six years of working on the SRY gene product, the initiating factor of testis determination, I am interested to complete my formation by the study of a major piece of the sex determination puzzle: the SOX9 protein. Gerd Scherer's group is to my knowledge one the best scientific environment to study this protein and its regulation: they hav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Advanced Technology to optimise Maritime operational Safety - Intelligent Vessel'.

assistant: **Innovation**

The ATAMOS IV project supports the main political issues of road-to-sea, Short Sea Shipping and Quality Shipping. Primary community benefits are the means to lessen on-shore congestion by applying a safety and cost-benefit regime to current Waterborne operations. The project provides a methodology for retrofit of the existing European Fleet, and demonstrates this by a full-scale retrofit to a trial vessel. Important technologies includes integrated ship control, human-centred design, Formal Safety Assessment and principles-based certification. ATOMOS IV is proposed by a highly experienced consortium made up a ship owner, a classification society, a national administration, two marine simulation centre, equipment manufacturers, human factors experts, two universities and marine consultants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NOCK: Real time safety for our senior relatives.' (NOCK), addressing dissemination and exploitation.

assistant: **Impact**

NEKI is a technological company created by seasoned entrepreneurs from different fields like Programming, Marketing and Management. We brought our expertise to this company in order to implement advanced safety solutions for person location and real time communication to relatives or health professionals.Alzheimer and other cognitive impairments are a key concern in a global scope, causing dis-orientation among our senior relatives and discomfort among people in charge of their wellness. Elderly people find difficulties in their daily activities and get lost without being able to find their way home or even telling other people where their address is. The risk of getting lost is real and one single night outdoors can be lethal to them.146,042 people disappeared in Spain  along last 20 years, and 6,053 have not yet been found, being most of them seniors or suffering cognitive impairment. Most advanced societies show similar seriousness figures.NOCK Project is the evolution of NEKI technology for a comfortable adaptation to senior people, who are provided with GPS location and communication systems, so they are constantly tracked by their relatives and caregivers.The system is composed of different technological pieces developed by NEKI along last 3 years and has already a great rate of paying customers and visibility, as we will describe along this document. Nowadays, closing an initial €130,000 investor round and achieving €60,000 from a public institution loan will lead us to our actual market deployment in European and Global scopes.The Project already counts on powerful stakeholders at technological and health & care sector levels, what has provided us not only with visibility but also with actual revenues.These stakeholders, together with gathered experience have le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A multi-generational study of psychosis in a founder population' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

This study aims to detect genes underlying functional psychoses. Its specific objectives are:To complete diagnostic measures on a sample stemming from three founder individuals in a relatively genetically isolated area of Norway.To analyse the structure of each family and obtain DNA samples from all individuals considered necessary for molecular and statistical analysis.To perform a genome scan using polymorphic markers and to carry out shared segment analysis to detect susceptibility loci. This project uses a unique population and novel methods to attempt to detect susceptibility loci for psychotic disorders. The research is based on an isolated population in Northern Norway in which a form of psychotic illness has been traced back to three founders alive in the 17th Century. Present day descendants of these founders are estimated to number 1,200 of which 250 individuals have been sampled from families with schizophrenia and bipolar disorder. Individuals have undergone a full indepth diagnostic interview and provided samples of blood for DNA analysis. Lymphoblastoid lines have been established, creating a permanent resource for future European research. In the first phase of the genome scan 36 descendants are being genotyped. A total of 160 polymorphic genetic markers have been run through the samples. A further 171 markers will be genotyped within months. In addition a set of markers is currently being selected to complete the genome scan with markers set at 5cM intervals. It is hoped that the knowledge gained by this research may form a basis for future treatments and prevention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High resolution structures of myelin proteins' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To attempt to obtain crystals of the lipophilic proteins and of the peripheral basic protein of myelin.To determine the molecular structure of these important constituants of the central nervous system in its myelin sheath membranes.This should be a first step towards the understanding of the molecular basis of neurodegenerative diseases such as multiple sclerosis. The proteins of myelin, the protective sheath enveloping neurones, are highly lipophilic membrane bound proteins (PLP), or associated with the membrane surface (MBP). While their primary structures (their amino-acid sequences) are known, in particular through work of some of the teams involved in the present project, their detailed 3D-structure, as it occurs in the membrane, is not precisely determined. It is therefore impossible so far to understand at the molecular level the exact mechanism of mutations leading to the widespread neurodegenerative diseases generally linked with myelin dysfunction, and therefore to design drug therapy on a rational basis. The programme comprises the isolation of pure myelin proteolipids, either by the use of powerful analytical procedures established by team 1 for the PLP/DM-20 family and by team 3 for MBP, or through the recombinant technologies introduced by team 6. The pure proteolipids will then be incorporated in a variety of phospholipids, especially synthesised by team 5 for the purpose, with short or longer side-chains, and various headgroups. The techniques developed by team 7 with other lipophilic membrane proteins to obtain cubic phase organisations will be used to attempt to induce formation of single crystals suitable for X-ray analysis by team 2. These lipid/protein systems will also be studied with the membrane probes developed by team 1 to define their topogra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Many-body Theory of Local Chemistry in Cavities' (MATHLOCCA).

assistant: **Concept**

Multiple experiments have demonstrated that chemical reactivity can be modified by collectively coupling molecules to electro-magnetic vacuum-modes of a cavity. This has led to a new interdisciplinary research field, often denoted as ""polaritonic chemistry"". Despite great effort, even key underlying theoretical mechanisms are not understood today. This has recently led to controversies about fundamental origins of the observations in the collective strong coupling regime.The main goal of MATHLOCCA is to develop a first verifiable quantum many-body theory for the problem. The theory will be truly many-body, discovering new physics in molecular models with a large number of coupled electronic, nuclear, and photonic degrees of freedom. Recent breakthrough findings of the applicant will lead to an unconventional ansatz: The theory explains polaritonic chemistry without polaritons. Instead it relies on the concept of collectively modified local dark states. This ""dark state chemistry"" will explain how collective strong coupling can modify chemistry on the single-molecule level, a long-standing open question. MATHLOCCA is multi-disciplinary, discovering fundamental new quantum many-body physics in new types of electro-vibro-photonic models. This will lead to applications also in cold atom platforms.A second main objective is to introduce a new numerical theory for general open quantum many-body simulations, in terms of an entanglement optimized density matrix unravelling. The key new paradigm is to dynamically optimize the unravelling of a density matrix into pure state trajectories, making the trajectories more amenable to classical representation. This new concept will radically shift capabilities for numerical simulations in polaritonic chemistry and beyond, while givi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Adding intelligence into clothing' (I-WEAR) under Fifth Framework.

assistant: **Objectives**

The project i-WEAR will design and implement a prêt-à-porter show in four European cities to present the state-of-the-art and future developments of intelligent clothes"(IC). IC means the integration of new technologies and materials in textiles. In future, clothes will be used as transmitters of chemical information, will carry scents or unguents or transform information into electronic signals. This development will have a sustainable impact on the clothing industry and on everyday life. The project i- WEAR aims at informing a broad public and the media about chances and challenges through IC. The project will consist of a road show through leading department stores. Particular emphasis will be laid on products with regard to "security" and "health". The show will be accompanied by a video, explaining the technical details. A moderator will lead through the show and will answer on questions from the public."