RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'T Helper cell lineages and their Cytokines in Autoimmune SKin Disease' (THC-ASKID) targeting Seventh Framework.

assistant: **Abstract**

Autoimmune skin diseases like psoriasis and atopic dermatitis are in part CD4 T cell mediated. After stimulation, CD4 T cells differentiate into different T helper cell lineages with distinct cytokine profiles. While in atopic dermatitis for example skin infiltrating T cells mainly show a Th2-polarization, in psoriasis, which is mediated by autoreactive T cells of the Th1-phenotype, recent evidence indicates an important pathogenic role for Th17 cells. However, it is not fully understood why a particular disease setting leads to a certain predominant T helper cell polarization and the consecutive skin phenotype. Given the high prevalence of psoriasis and atopic dermatitis in western countries, it is of great interest to elucidate the mechanisms of disease development and how they can be manipulated therapeutically.Previously I have shown that Scurfy mice harbor autoreactive T cells recognizing antigens in the skin and developed the “Scurfy Transfer Model”. In this model autoreactive CD4 T cells from Scurfy mice are transferred into RAG-/- recipients and induce skin disease within 4 weeks. Thus I am now able to transfer either naive or different types of pre-differentiated CD4 T helper cells and to analyse the resulting skin phenotype. The following questions will be addressed: Which T helper cell polarization will spontaneously occur after transfer of naïve auto-reactive T cells into RAG-/- recipients? Which factors lead to that particular development? Which skin phenotype is induced after transfer of pre-differentiated Th1, Th2, Th9 and Th17 T helper cells? Are there shared phenotypic features of the induced skin phenotype and human autoimmune skin diseases? How can T helper cell polarization be manipulated in vivo?In conclusion, the general objective of this research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Wave-vector-dependent tunneling in novel superconductors'.

assistant: **Concept**

We will investigate the k-space dependence of the superconducting energy gap A in thin films of the high-temperature superconductors Bi2Sr2CaCu2O8+E and Bi2Sr2Ca2Cu3010+E. The special interest in this study arises from the fact that Bi-2212 is a candidate for the unconventional d-wave pairing state through a coupling mechanism different from the usual BCS concept. The proposed experiment implies the fabrication of Josephson tunnel junctions. In a first step we will prepare epitaxial films and pattern them into microbridges along well defined crystallographic axes. Tunnel junctions along the different directions will be produced either by narrowing the microbridges to nanobridges or by the deposition of a ferromagnetic layer across the microbridges. In order to study the anisotropy of the energy gap A(k,T), current-voltage characteristics will be measured, since the critical current is related to A(T). The assumption of a d-wave state predicts the vanishing of A for specific crystallographic directions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Services to enhance the innovation management capacity of SMEs in macro-region 1 in Romania', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Consultation of Enterprise Europe Network partners on the work programe for 2020-20 H2020 activitiesServices to enhance the innovation management capacity of SMEs in macro-region 1 in RomaniaThe proposal objectives are the following:- increase the efficiency and effectiveness of innovation process by offering services for enhancing the innovation management capacity of SMEs the H2020 programmes for specific activities in the context of innovation support and the enhanced European Innovation Council (EIC) pilot; - facilitate SMEs access to consultancy services for innovation management to address bottlenecks in order to create an economic impact; - support innovative SMEs to raise the company's profitability and competitiveness on international markets.


**Keywords:** Increase the efficiency and effectiveness of innovation process for local SMEs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sensor Technology for Food analYsis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of STEFY project is to facilitate SMEs and large companies in the food safety testing with a new portable device,particularly effective and economically convenient to regularly self-check food safety. STEFY device main innovationlies on the ability to quickly determine and simultaneously quantify the presence/absence of dozens of molecules for on-siteapplications. This is due to the newly developed cartridges: glass substrate with advanced anti-reflection coatings combinedwith functionalized nanoparticles for an optimal signal amplification resulting in a competitive assay. The technology used isbased on the Reflective Phantom Interface, an innovative methodology patented by Proxentia, which has been alreadyextensively tested and compared with already existing strategies. The key competitive features of the STEFY tester areseveral: reduced test duration; simultaneous broad-spectrum monitoring; on-site applicability; versatility; low cost. Theoutcomes of the STEFY project will: a) facilitate opportune procedures for prevention and/or damage containment; b) reducerisks related to the introduction of potentially dangerous material; c) reduce the use of laboratories to only the most relevantcases; d) reduce the costs while improving quality (lower level of residuals on the product and a reduced environmentalimpact. With this project the objective is to launch the tester device with customized cartridges in the European market as afast, reliable and cost-effective way to assess food safety. The current technology readiness level of STEFY project is TRL 7and it aims at reaching TRL 8-9 by Phase 3. The financing from Phase 2 will provide STEFY with key suggestions on how toupscale and customize the device to best fit different application-fields, insights on the tools
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Structuring Effective Climate Change Agreements through Perfect Procedures: an Experimental Approach' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Structuring Effective Climate Change Agreements through Perfect Procedures: an Experimental Approach (SECCAPPEA)The solution to the climate change problem can be no longer postponed because more and more indicators are showing that we are getting closer to the tipping point of an irreversible process. At the same time, climate change is a global issue that cannot be tackled by means of the commitment of a minority of virtuous agents or communities. Instead, problems of global outreach like the global warming can be solved only through a high degree of international cooperation: this is exactly the main goal of the international agreements on climate actions. However, despite several international agreements signed during the last decades for the global reduction of greenhouse gas emissions, nations have generally failed to comply with the prescriptions of climate change agreements, so that greenhouse gas emissions continue to increase. This lack of commitment produced no relevant changes in terms of reducing the risks related to climate change. The SECCAPPEA project, through methods and tools belonging to behavioural and experimental economics, aims to study and examine perfect procedures as a new way to structure self-enforcing international climate change agreements, so that they can produce tangible results, reducing the likelihood of the world heading into the so-labelled “climate chaos”. The project will last 24 months and will be developed between the School of International and Public Affairs (SIPA) at Columbia University (associate partner for the outgoing phase) under the supervision of Professor Scott Barrett, and the Cognitive and Experimental Economics Laboratory (CEEL) at the University of Trento (beneficiary) under the supervision of Professor Luigi Mitton
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The therapeutic potential of Genipin as a corneal cross-linking agent: Unlocking a new pathway for the treatment of corneal infection and disease.' (CORLINK) under Horizon 2020.

assistant: **Objectives**

Keratoconus is an eye disorder in which the normally curved cornea, the clear window of the eye, progressively thins and begins to bulge into a cone-like shape, leading to significant visual impairment. Corneal cross-linking is the gold standard treatment for halting disease progression by using riboflavin activated by ultraviolet light (UVA) to introduce covalent chemical bonds (cross-links) into the cornea. To enhance permeability of riboflavin into the corneal stroma, epithelium removal is required and thus, patients with thin corneas are not eligible for this approach, as several complications have been reported, some temporary and some irreversible. There is, therefore, an urgent need to develop new innovative therapeutic approaches that ideally avoid deepithelialization and the use of radiation. Genipin, is a naturally occurring cross-linking agent that has been proposed to have a biomechanical effect comparable to that of the contemporary cross-linking approach, without the need for deepithelization, and importantly to exhibit anti-inflammatory properties. This research will investigate the potential application of Genipin for the treatment of keratoconus corneas and corneal inflammatory diseases. With the overarching aim to elucidate the efficacy and mechanism of action of Genipin in the cornea and to ascertain its anti-inflammatory activity on resident corneal cells called keratocytes, a combination of biomedical techniques and advanced 3D structural imaging modalities will be integrated, in a drive towards the establishment of a new therapeutic strategy for keratoconus and inflammatory diseases. The results of this study will elucidate the effect of Genipin on corneal keratocytes in vitro and in vivo and will provide the first ever direct measurement of the ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metabolic heterogeneity of monoclonal bacterial cells as a biotechnological tool to produce natural compounds.' (MENTHOL) targeting Horizon 2020.

assistant: **Abstract**

This proposal aims to change current paradigms of biotechnological production of complex plant natural compounds, specifically isoprenoids such as limonene, menthol, and p-cymene. MENTHOL main innovation lies in the synthetic decoupling of the complex biosynthetic pathways of these compounds into a distributed catalysis within monoclonal heterogeneous bacterial populations. Limonene and menthol are natural monoterpenes widely used as flavor and fragrance additives, while p-cymene is an important precursor in the bio-based production of terephthalic acid, a key precursor of Polyethylene Terephthalate (PET). Although they have been successfully produced by genetically engineered microorganisms, to reach industrial scale production there are still obstacles to overcome. On the one hand, the introduction of large biosynthetic pathways in a single bacterial strain may cause host unstable physiology and low performance; and on the other hand, the use of synthetic consortia to overcome this shortcoming can be limited by differences in the growth profile of species involved. This proposal is conceived as an alternative to avoid those obstacles, by decoupling the complex biosynthetic pathways of the target compounds into minimal functional modules, to be reassembled inside metabolically differentiated subpopulations of a single specie-based multifunctional bacterial culture. To achieve such ambitious goal, in this project we will applied cutting-edge systems and synthetic biology tools to engineer programmable metabolic heterogeneity inside a monoclonal population of Pseudomonas putida, to promote the division of labor during the production of limonene, menthol, and p-cymene using waste cooking oils as economic and reliable renewable feedstock.


**Keywords:** Bacterial Metaboli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Polarization Phenomena in Quantum Microcavities'.

assistant: **Concept**

The investigation of light-matter interactions nano- scale objects attracts the growing interest of researchers. This interest is largely motivated by the possibility of reaching the strong light-matter coupling regime, where the elementary excitations – polaritons – have a hybrid, half-light half-matter nature. The unusual properties of the polaritons make them a unique laboratory for study of fundamental quantum effects such as high temperature Bose Einstein condensation, superfluidity, entanglement etc. The important property of the polaritonic systems is their polarization (spin) properties. The interplay between bosonic stimulated scattering of cavity polaritons and their spin precession under effective magnetic fields of various origin makes polarization dynamics in quantum microcavities extremely rich and interesting from fundamental point of view. Moreover, the possibility to manipulate spin of polaritons opens a way to experimental realization of optoelectronics devices of new generation, i.e. spinoptronic devices. With respect to optics, spin-optronics has the advantage of being able to use well controlled carrier interactions occurring in nanostructures. With respect to ‘spintronics’, it has the advantage of strongly reducing the dramatic impact of carrier spin relaxation or decoherence, which has severely limited the achievement or the functionality of any working semiconductor-based spintronic devices.Our research will be aimed at theoretical study of the coherent polarization (spin) phenomena in quantum microcavities with embedded quantum wells and dots in order to formulate practical recommendations for design of various spinoptronic devices: all- optical locical gates, optical circuits, polarization filters and sources of entangled photon pairs.In order
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanoscale Vertical Cavity Surface Emitting Laser and its Arrays' under Horizon 2020.

assistant: **Concept**

Significant advances are needed to improve the speed and efficiency of future communication and computing systems. Photonic interconnect components are the only solution to offer both high speed and low power consumption. To this end, vertical-cavity surface-emitting lasers (VCSELs) have been widely deployed as optical interconnects in the last two decades. Even though the current VCSEL technology has been very successful, its processing approach has been proven to be particularly challenging for miniaturization, it reduces the reliability for small lasers and its high thermal resistance substantially degrades the lasers’ performance. This project addresses all these bottlenecks by focusing on the development of a nanoscale VCSEL (NOVEL) device for ultra-low threshold, energy efficient and ultra-fast operation for future optical interconnects and light sources.The driving idea of this proposal is based on using a lithographically defined laser concept to develop a novel growth and fabrication process for GaAs-based VCSELs. This will employ buried electrical- and optical-confinement method to provide us with a unique opportunity to scale the cavity down to 500 nm diameter to demonstrate the viability and performance of the NOVEL device. Additionally, this research proposal aims to investigate the potential of NOVEL array architectures for applications in sensing and innovative high beam quality lasers. This project is expected to have a strong impact both in academia and industry as it will open the way for great flexibility in the design of VCSELs and nanolasers with high reliability essential for commercialization of research. The NOVEL devices with their fundamentally new capabilities hold special promise in a wide range of scientific disciplines including optical com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Novel Air Distribution Approaches', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

NADiA project will research, develop, design, manufacture and test technologies and solutions aiming at significant improvements of the air distribution system (ADS), using the example of a 90 passenger advanced turboprop aircraft.The integrated improved cabin ADS is one of the key contributors to the environmental challenge of the ITD Airframe activities in reducing the structural weight by 4% to 6%, the CO2 and NOx, footprint by 3% to 5%, while enhancing passenger comfort by reducing noise and vibration. NADiA will significantly improve the ADS by 15% in weight, 3dB in acoustic and 20% in cost.Development, manufacturing costs and assembly times will be reduced, and production rates will be increased. To achieve the overall goals, ‘beyond state of the art’ technologies will be developed and verified in dedicated tests up to TRL6.The key end goal of NADiA will be to fully integrate and test the novel ADS in the cabin demonstrator located at Fraunhofer IBP in Holzkirchen (Topic Manager), as well as to provide support for the Environmental Control System (ECS) testing performed by Fraunhofer IBP.NADiA consortium applies advanced design principles, innovative system architectures, advanced materials and processes to generate high potential air distribution solutions for next generation turboprop aircraft.NADiA participants have a longstanding experience in ADS and ECS products. Diehl Aviation Laupheim integrates ADS for all Airbus aircraft programs, including the mixer for the A350. The delivered systems are developed and simulated using CAD and CFD software solutions. Diehl Aviation Gilching developed and manufactures vans and air cooling devices for several Airbus programs.NADiA total grant request to CS2JU is 1 299 271.25€ for the whole consortium and will be conducted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Learning to Learn - Medial Prefrontal Cortex as Meta-Learning System in the Brain' to be submitted under Horizon 2020.

assistant: **Abstract**

In a changing environment the ability to continually and rapidly learn new behaviors is crucial for humans and animals to survive. How the brain stores and integrates new information without forgetting (continual learning, CL) and utilizes prior knowledge to quickly adapt to new situations (fast forward generalization, FFG) remains a mystery. To shed light on this crucial question I propose a novel interdisciplinary approach that derives inspiration from a theoretical machine-learning approach for artificial neural networks (ANN) and simultaneously addresses FFG and CL. In this dual-network model, a so-called meta-network learns to identify the context for all previous tasks and modulates a second, stimulus-processing network, in a task/context specific manner to efficiently solve the task. As a result, similar task contexts elicit the selection of similar stimulus processing networks thereby enabling FFG. In the brain, the medial prefrontal cortex (mPFC) is known to receive contextual information (environment, setting), to store task information and to project to sensory areas. This makes it a promising candidate to function as a meta-network in the brain. In the proposed study, I will investigate if and how the mPFC affects sensory processing in a task-specific manner during CL and FFG, functioning as a meta-network. I will utilize cutting-edge experimental techniques including miniaturized microscopes in freely behaving mice to record neuronal populations in mPFC during FFG and CL combined with chemo- and optogenetic tools. To investigate how mPFC affects stimulus processing on the single neuron level, I will combine calcium and voltage imaging in brain slices. This interdisciplinary project will provide novel insights into the possible implementation of meta-learnin