RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Herpesvirus Effectors of RNA synthesis, Processing, Export and Stability' to be submitted under Horizon 2020.

assistant: **Abstract**

Herpes simplex virus 1 (HSV-1) is an important human pathogen, which intensively interacts with the cellular transcriptional machinery at multiple levels during lytic infection. Employing next-generation sequencing to study RNA synthesis, processing and translation in short intervals throughout lytic HSV-1 infection, my laboratory made the surprising observation that HSV-1 triggers widespread disruption of transcription termination of cellular but not viral genes. Transcription commonly extends for tens-of-thousands of nucleotides beyond poly(A)-sites and into downstream genes. In contrast to textbook knowledge, HSV-1 infection does not inhibit splicing but induces a broad range of aberrant splicing events associated with disruption of transcription termination. Exploring these fascinating phenomena will provide fundamental insights into RNA biology of human cells. The proposed work combines both hypothesis-driven and innovative unbiased screening approaches. I will utilise cutting-edge methodology ranging from high-throughput studies to advanced single molecule imaging. Thereby, I will detail the molecular mechanisms responsible for disruption of transcription termination and aberrant splicing. I will identify novel cellular proteins governing transcription termination using a genome-wide Cas9-knockout screen. I will develop RNA aptamer technology to visualise and track single RNA molecules suffering from poly(A) read-through. I will elucidate why transcription termination of some cellular and all viral genes remains unaltered throughout infection. I hypothesize that the alterations in RNA processing are depicted by specific changes in RNA Polymerase II CTD phosphorylation and in the associated proteins. I will characterise these dynamic changes using mNET-seq and quan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An On-board Dynamic Vision Sensor Suite for Enhanced Satellite Self and Situational Awareness' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The current overpopulation of satellites in orbit requires decisive actions to ensure safe operations in the near-Earth environment. These actions are particularly challenging, as only a fraction of objects in orbit are cooperative satellites, while the majority are space debris, which includes inactive satellites, rocket bodies, and fragments of all sizes. Space debris significantly raises the risk of collisions, and its continued increase could render space activities unsustainable in the future. In this context, developing the capability to detect, identify, and track orbiting objects is essential for predicting their trajectories and assessing potential conjunctions with other satellites. Additionally, advancing technologies for proximity operations is vital for enabling large-scale active space debris removal and servicing missions.The AstrAware project aims to contribute to both tasks through a sensor suite that provides long-range and close-range characterization of a detected target. To achieve these two functions, the project will employ a sensor suite that incorporates innovative dynamic vision sensors with novel data processing pipelines. Central to this system is the integration of a neuromorphic camera, optimized for detecting debris through its heightened sensitivity to illumination changes, alongside an adapted star tracker that functions as a dynamic vision sensor. By working together, these sensors not only share data but also enhance each other's performance, providing continuous optical information for both far- and close-range navigation. This synergy allows for precise proximity operations, seamlessly incorporating debris detection and attitude control within a single, efficient sensor suite, delivering significant operational advantages.


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ExoData: a commercially supported space telescope' in the context of a Horizon 2020 call.

assistant: **Objectives**

ExoData will use results from the very successfull ExoMol Advanced Award which created comprehensive spectroscopic line lists to help understand and model the atmospheres of exoplanets. ExoData will help build and fund a satellite aimed at characterising exoplanet atmospheres using a cheap, agile, low earth orbit satellite mission with a launch date this decade. This mission will be part funded bythe sale of telescope data to interested international clients. This is a new business model for astonomical satellites. ExoData will (a) fund business development in partnership with a small company createdto sell telescope and other data from this mission and (b) use the results of the ExoMol project to model results from this mission and to create software and models that have potential re-sale value.The deliverable will be funded space mission and a novel business model.


**Keywords:** space
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Terabit-on-chip:\nmicro and nano-scale silicon photonic integrated components and sub-systems enabling Tb/s-capacity, scalable and fully integrated photonic routers'.

assistant: **Innovation**

BOOM is an integration project that aims to pursue the systematic advancement of Silicon-on-Insulator (SOI) integration technology to develop compact, cost-effective and power efficient silicon photonic components that enable photonic Tb/s capacity systems for current and new generation high speed broadband core networks. BOOM develops fabrication techniques as well as flip-chip bonding and wafer-scale integration methods to fabricate and mount the complete family of III-V components on SOI boards including: arrays of Semiconductor Optical Amplifiers, monolithic blocks of Electro-absorption modulated lasers (EMLs) and highly efficient photodetectors. As such the BOOM SOI optical board technology will be able to blend the cost-effectiveness and integration potential of silicon with the high bandwidth and processing power of III-V material and provide a new generation of functional and miniaturized photonic components including: (a) a single 160 Gb/s SOI Wavelength Converter (WC) and a quadruple array of 160 Gb/s WCs with a record chip throughput of 640 Gb/s on a size 20x5 mm2 , (b) a compact, eight channel, ultra dense WDM InAlAs-InGaAs photoreceiver with record high responsivity and (c) a dual SOI EML transmitter together with its electronic drivers on a single chip. In addition, BOOM invests in the development of improved CMOS compatible waveguide technologies to fabricate miniaturized, low loss and fully reconfigurable wavelength routing cross-connects based on two dimensional grids of serially interconnected micro-ring resonators. BOOM will perform system level integration of all these components to assemble the first prototype rack-mount, ultra-high capacity routing platform based on silicon photonics that will require minimum board space and power consumption and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Improving Subsidence PREdictions in Delta systems'.

assistant: **Objectives**

Almost 500 million people live in river deltas, which host among the most important areas for economic activities and global food production on the planet. Relative sea-level rise (RSLR) in delta systems is predominantly caused by land subsidence and accelerating subsidence rates threaten the future existence of these low-lying landforms, including their inhabitants, environment and economy. Reliable projections of future RSLR are urgently needed to prospect the fate of sinking delta systems but their creation is presently hampered by our inability to accurately resolve delayed subsidence. This causes uncertainties in subsidence rate projections potentially much larger than climate-change driven rates of sea-level rise.The InSPiRED (Improving Subsidence PREdictions in Delta systems) project aims to improve our ability to quantify delayed subsidence by upgrading a novel, physics-based numerical simulator and to develop a generic integrated approach at create accurate RSLR projections for sinking coastal-deltaic areas. These will facilitate the design of effective management strategies for local delta policymakers. The approach will be designed for different temporal and spatial scales, ranging from decennial to millennial and from a single marsh to an entire delta, respectively, in three major delta systems, the Po, Mississippi, and Mekong deltas.Both the applicant and the research group have strong track records of cutting-edge subsidence research with different disciplinary backgrounds. The applicant will bring geomorphological and geological knowledge to the research group, leading in geomechanical engineering and numerical modelling. This will enable the inter- and multidisciplinary research required for this project and facilitate transfer of ideas. The project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanobiology of Bovine Reproduction', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The global demand for dairy products is expected to surge by 36% over the next decade in a manner that is progressively insatiable by existing technologies. The dairy industry relies on bovine reproduction, yet cow fertility is declining and the exact causes are not fully understood. It is clear, however, that the quality of bovine oocytes is decreasing. In mammals, the ovarian reserve of oocytes stored within quiescent primordial follicles is non-renewable. Oocyte develop and mature within distinctive follicular microenvironments under tightly regulated molecular and physical conditions. Similarly, preimplantation embryo development is supported within a specialized microenvironment that is surrounded by the zona pellucida and insulated from external soluble and mechanical inputs. Characterizing and understanding these environments and how they affect reproductive processes is a key toward improving assisted reproductive technologies in bovine species.Our premise is that molecular characterization of endocrine and paracrine signalling pathways must be complemented with understanding the mechanical regulation of reproductive biology. This premise is supported by recent finding showing that physical stresses and the mechanical compliance of the extracellular surroundings serve as potent regulators of cell fates in regeneration processes, development, and disease.I propose to employ a biophysical and computational toolbox to study the mechanobiology of reproduction with application to bovine embryo-based technologies. By mimicking the mechanical properties of the ovarian cortical niche, which I will characterize using freshly derived ovaries, I will design an in vitro system for supporting follicle growth. Mechanical profiling of the entire developmental course from oocyt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Global Communication Architecture and Protocols for new QoS services over IPv6 networks'.

assistant: **Innovation**

High performance networking with guaranteed Quality of Service (QoS) is one of the major challenges of the next decade. It mandates very important efforts to provide multimedia and multicast communications to wide area advanced users, because the limited mechanisms of UDP (User Datagram Protocol) and TCP (Transmission Control Protocol) cannot adequately support innovative distributed applications. Furthermore, future architectures will involve heterogeneous networks, as new satellite and terrestrial networks having sophisticated intelligent services. As a consequence, GCAP aims at developing for the future Internet two new end-to-end multicast and multimedia transport protocols, embedded in a new global architecture to provide a guaranteed QoS to advanced Multimedia Multipeer Multi-network applications. In order to rapidly experiment the proposed solutions, an efficient deployment of the communication software will be developed over an industrial IPv6 layer by using a programmable active network based technology.Objectives:The objectives of the project are:- to define and evaluate a new end-to-end multicast transport protocol and a new end-to-end multimedia multicast transport protocol for supporting dedicated or specialised applications having guaranteed QoS requirements;- to define and evaluate a new integrated global multi-network end-to-end architecture for supporting innovative multimedia and cooperative applications needing guaranteed Quality of Service;- to propose a design approach to rapidly deploy and use such new protocols, that will be developed on top of the new QoS architecture based on IPv6 and DiffServ, by means of an active network based technology;- to illustrate the feasibility and evaluate the potential of the advocated approach by conducting two exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genetic and Epigenetic Determinants of Paget's Disease of bone' in the context of a Seventh Framework call.

assistant: **Objectives**

Paget’s disease of bone (PDB) is a common disease characterised by focal areas of increased bone turnover leading to symptoms of bone pain, deformity, osteoarthritis and other complications. Genetic factors play an important role in PDB and mutations in SQSTM1 gene are responsible for ~10% of PDB cases with high penetrance. We have recently identified seven additional susceptibility loci for PDB using genome-wide association studies (Albagha et al, 2011; Nat Genet). These recently identified loci have a combined effect that explained about 13% of familial risk suggesting that other genetic factors remain to be identified. The aims of this project are three fold: 1) to define the functional variants in the recently identified susceptibility loci using targeted DNA sequencing, 2) To identify novel genetic variants for disease susceptibility using exome sequencing in PDB patients without SQSTM1 mutations, 3) To investigate the role of epigenetic factors and their interaction with genetic factors in the pathogenesis of PDB. We will study genome-wide DNA methylation patterns in PDB patients and controls to identify differentially methylated sites associated with PDB. The contribution of epigenetic factors to the focal nature of PDB will be studied using an animal model of PDB to assess if epigenetic changes are specific to bone lesions and to determine if these changes contribute to disease development or occur as a consequence of the disease.  Identification of genetic and epigenetic factors that predispose to PDB will increase our understanding of disease mechanisms and could also identify novel molecular pathways that could form targets for new therapeutic treatment not only for Paget’s disease, but also other diseases associated with increased bone turnover. These factor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'REciprocal LOcal ADapatation: the genetic, behavioural and chemical study of the evolutionary maintenance of a mutualism' (RELOAD).

assistant: **Concept**

The goal of this research is to identify and characterize genetic, behavioural and biochemical mechanisms underlying reciprocal local adaptation between partners in a complex mutualism. It will focus on a unique and outstanding model system found in the New World tropics: the “devil’s gardens” created by the ant, Myrmelachista schumanni, whose workers systematically attack and kill seedlings of foreign plants that germinate too close to their host plants. This cultivation behaviour results in low diversity, orchard-like stands of their host plants in the middle of some of the most diverse rainforests on earth.  This project will bring together researchers from Harvard University and the Max Planck Institute to address three main questions through a combination of newly developed genome sequencing techniques, large-scale field-ecology behavioural experiments and state-of-the-art chemical analyses: (1) Do Myrmelachista schumanni and its host plants reciprocally influence each other’s population sizes, level of gene flow and genetic structure? (2) How specialized are interactions between Myrmelachista schumanni and the several species of plants that it cultivates? (3) What are some of the proximate mechanisms underlying host specificity, and in particular, can ants recognize different plant species and if so, how? In carrying out this research, postdoctoral fellow Pierre-Jean Malé will expand his expertise by gaining training in phylogenomics and chemical ecology. The project, referred to here as ""RELOAD"" (forREciprocal LOcal ADaptations), will also enable him to broaden the ecological and evolutionary scale of his research, and enhance his long-term goal of obtaining a faculty position at a European university and/or research institution.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Personal Plane: Assessment and Validation of Pioneering Concepts for Personal Air Transport Systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The PPlane project is a direct follow up study to Out-of-the-Box project that aimed to identify potential new concepts and technologies for future air transport and focused on a number of radical changes to the system rather than taking incremental steps.As a result of the Out-of-the-Box project, PPlane implements a systematic approach to radical and novel ideas for Personal Air Transport System (PATS). The project starts with the definition of several operational concepts and implements an optimisation model and several selection criteria to suggest and analyse new concepts for the personal air transport system of the future. The main selection criteria include: “Security and safety”, “Automation and Control”, “Environment”, and “Human Factors”. Horizontal areas such as technologies, regulation and affordability are considered in each of the above criteria. The resulting concepts are analysed and compared resulting in recommendations for implementation across Europe.The PPlane team is led by ONERA and comprises well known organisations in the field of aviation from different domains including industry, research and academic institutes. Additional external experts will be invited to the advisory board.PPlane’s objectives and methodology are an excellent match with the objectives of AAT.2008.6.3.3. ""Personal air transport systems"" and in particular with AREA: 7.1.6.3 “Promising Pioneering Ideas in Air Transport” matching the expected impact of “assessing the viability or paving the way towards the realisation of the new ideas and concepts identified by ACARE”. Moreover, the definition of the PATS concepts will be built according to the ATM structure planned in SESAR.""