RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Decoding Stress Resilience'.

assistant: **Objectives**

Stress is a common feature of our lives yet some people respond to stress better than others, a concept known as resilience. There is a growing body of experimental data which has implicated several brain structures and molecular mechanisms. However to date there has been limited focus on the bed nucleus of the stria terminalis (BNST) and the mechanisms in this brain region which could be involved. One of several proteins expressed by the BNST, which is a key regulator of the stress response, is the pituitary adenylate cyclase-activating peptide (PACAP). But the expression of PACAP is under the control of stress-responsive nucleotides called miRNAs. Thus, there exists a complex system in the BNST which regulates the stress-response and hypothetically could be involved in mediating resilience. To test this hypothesis, the DE-STRESS project will conduct a series of experiments with the objectives of (i) determining whether PACAP expression in the BNST is different in states of resilience and susceptibility, (ii) identifying miRNAs that are differentially expressed in these states and which regulate PACAP expression and (iii) elucidating their functional effects on the stress response.  Hence, the DE-STRESS project uses an innovative approach to decode the concept of stress resilience and will advance understanding of the pathophysiology of stress-induced disorders. Additional objectives of the project include dissemination and transfer of knowledge to relevant stakeholders, forming collaborations within academia and industry with a view to commercialising research findings as well as develop project management and career development skills of the applicant. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Integrated sensor techniques for industrial combustion monitoring and control' to be submitted under Fourth Framework.

assistant: **Abstract**

Current and proposed emissions legislation is demanding ever more stringent restrictions on the discharge and monitoring of exhaust pollutants from industrial combustion processes. Pollutant formation in a combustion process varies with temperature, but at present there is no economical and reliable direct method to measure this parameter. Normally, firing temperature is derived from iterative calculations based on the measurements from several indirect process parameters. Due to the inherent errors of this technique some temperature margin must be allowed to avoid weak extinction". Additional fueling required to maintain adequate margins will increase pollutants and decrease efficiency. Conventional methods for measuring and monitoring exhaust emissions are not readily acceptable due to excessive first cost, and more importantly the need for frequent calibration and maintenance. Manufacturers of sensors have been researching methods for direct measurement of combustion temperatures and exhaust emissions which would be both cost effective and reliable. The objectives of this programme are to research, manufacture and validate the operation of non intrusive sensors to measure process temperatures within natural gas fired lean burn combustors, and other sensors to measure exhaust emissions. The sensor research will be supported by a quantitative study of the combustion process of natural gas, the results of which can be incorporated into existing computational fluid dynamics packages to aid the design of advanced combustors. A further objective is to demonstrate, under realistic operating conditions, that the outputs from the sensors can: a) be utilised within an electronic management system to regulate the combustion process and thus minimise emissions, b) eventually be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The emotional signature of anhedonia in depression and psychosis in daily life: Developing a fine-grained and temporal understanding using advanced Experience Sampling Methods' in the context of a Horizon Europe call.

assistant: **Objectives**

Depression and psychosis in adolescents and emerging adults have a significant economic, health, and social burden on an international scale. Targeting transdiagnostic factors that are common across disorders, and doing so early before symptoms develop or worsen, is critical to maximise impact and get more bang for buck. Anhedonia, the pervasive inability to anticipate and experience pleasure or interest, is a transdiagnostic feature of depression and psychosis. Anhedonia has received comparatively little research attention compared to other symptoms, meaning that it is not well understood or addressed in therapy. The current research will use existing high-quality datasets in an ambitious exploration of the emotional processes related to anhedonia in depression and psychosis, with a focus on adolescents and emerging adults. It will extend prior research by using advanced real-time methodologies that provide a fine-grained and temporal understanding of emotional experiences in anhedonia in daily life. This approach will dramatically advance the field by aiding the future development of transdiagnostic techniques targeting anhedonia that are more effective than those currently available. The workplan also outlines training and career development activities that focus on experience sampling methodology, complex multilevel and time series data analysis, open science, and building transferable professional skills to lead an independent and productive lab. These skills will underpin the fellow’s ability to establish a profile as an up-and-coming researcher with a competitive edge for funding and employment. The research fellow and supervisor are the ideal team to conduct this work. The fellow’s strong background in research on youth depression and digital programs delivered
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Science education for action and engagement towards sustainability' to be submitted under Horizon 2020.

assistant: **Abstract**

The main objective of the Science Education for Action and Engagement Towards Sustainability (SEAS) is to establish, coordinate and evaluate collaboration among six open schooling networks led by universities and science centres with partners in Austria, Belgium, Estonia, Italy, Norway, Sweden, and the UK. As part of these networks, and drawing on principles of inquiry-based science learning for transformative engagement, students in formal schools are given the opportunity to engage in addressing real-life, complex sustainability challenges that are identified and dealt with together with participants and stakeholders in the local community. SEAS develops and makes us of models for open-schooling implementation that supports schools and out-of-school institutions to collaborate in the promotion, among students and citizens in the larger community, of 21st century scientific literacy and skills for responsible citizenship. SEAS delivers enhanced opportunities for students and citizens to develop deeper interest in science and inclusive scientific literacy, both in the target communities and beyond them taking into account gender, socio-economic status and geographical differences. By providing facilitation and mediation tools and methods for the identification and implementation of sustainability challenges in the participants’ local communities, SEAS makes it possible for students to collaborate with families and stakeholders from civil society and industry in becoming agents of community well-being. SEAS provides participants with the necessary expertise, networking, and sharing resource experience to address these challenges and, in doing so, develop deeper scientific literacy skills and interest in science education and careers. SEAS also contributes to generating m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modeling and treating retinal degenerative disease' in the context of a Horizon 2020 call.

assistant: **Objectives**

Gene therapy using adeno-associated viral (AAV) vectors has shown early promise in clinical trials. The therapeutic transgene cassette can be packaged in different AAV capsid pseudotypes, each having a unique transduction profile. At present, AAV capsid serotype selection for a specific clinical trial is based on effectiveness in small animal models. We (and others) have shown substantial progress in improving gene therapy for eye diseases in rodents. However, small animal studies are not often predictive of human outcome when it comes to the efficacy of viral delivery. Moreover, non-human primates used as pre-clinical animal models do not display any pathology making them unsuitable for testing efficacy. Here, I propose to overcome these bottlenecks in translational gene therapy by generating non-human primate models of retinal degeneration where effects of therapies and prosthesis on sight restoration can be tested. Generating transgenic primates using germline transgenesis would be very costly and ethically problematic. I thus propose to induce retinal disease locally, following delivery of pathogenic genes within specific subsets of cells in the non-human primate retina (Aim A). In Aim B, I propose to develop novel AAVs for use in human gene therapy using directed evolution. This bioengineering approach has yielded AAVs with enhanced delivery properties in the murine retina and applying it to post-mortem human retinas will generate AAVs responding to a clinical need in gene therapy. All together, the creation of models of disease in primates combined with novel AAVs tested in human post-mortem retinas will enable us to validate therapies aiming at vision restoration and neuroprotection in retinas with a macula and high central visual acuity, removing a major roadblo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Improved decision-making in contaminated land site investigation and risk assessment'.

assistant: **Concept**

The REMEDIATE ETN comprises 10 beneficiaries (from 5 EU Member States – the UK, Ireland, Germany, Denmark, and Italy) and 15 partner organisations. The beneficiaries and partner organisations are committed to the provision of innovative research and training for more cost effective and sustainable remediation of contaminated land. It is a multidisciplinary collaboration between internationally renowned research teams (from both the academic and non-academic sectors) each with complementary expertise in a wide range of site investigation and risk assessment technologies. 14 Early Stage Researchers (ESRs) will be recruited into the network and will participate in a structured and integrated research and training programme that will provide them with a highly specific blend of personalised technical and transferable skills. Each research project is designed to benefit the contaminated land sector through development of techniques and tools across a range of disciplines relating to site investigation and risk assessment, to provide better informed solutions for remediation. The unique provision of joint supervision (from both the academic and non-academic sectors) and non-academic mentoring will significantly enhance the fellows’ career prospects within the contaminated land sector. The REMEDIATE ETN will strengthen and enhance existing collaborations between the participating beneficiaries and partner organisations resulting in a cohesive and dynamic network. The output will be a new generation of highly mobile, creative and innovative entrepreneurs with the skills sets necessary to address the technical, economic and social challenges facing the contaminated land sector in Europe, both now and in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Social Justice and the Future of Work' in the context of a Horizon 2020 call.

assistant: **Objectives**

The aim of this project is to develop and defend a theory of justice for contemporary labour markets in the light of recent and ongoing changes in modern labour markets (in particular the rise of automation, the changing nature of the firm, and the evolution of the gig economy). These trends are receiving sustained analysis by researchers in economics, computer science, and business who tend to evaluate the labour market primarily in terms of economic efficiency. No doubt, this is one of the criteria by which we should assess labour market policies, but it is not the only one. When assessing labour markets, we must also be attentive to the distribution of the benefits and burdens of social cooperation, as well as to which rights individuals possess. I will explore these issues using the tools of normative political philosophy.   In the course of this research, I will (i) develop a better understanding of how liberal egalitarian political philosophy can profitably engage with and influence the analysis of public policy, and (ii) develop my capability for engaging with findings in quantitative social science. I will do this under the supervision of Prof. Andrew Williams, who is Editor of Politics, Philosophy & Economics, and Prof. Javier Arregui, who is a specialist in European public policy. The project will be based in the Department of Law at the Universitat Pompeu Fabra (UPF), which hosts an assembly of world-renowned political philosophers working on related themes. The project involves an ambitious dissemination and communication plan. In addition to several seminar presentations and deliverables, I will maintain a project website, organise an international conference, convene a panel at the American Political Science Association Annual Meeting, participate in works
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'HOLIstic optimisation of SHIP design and operation for life cycle' (HOLISHIP) under Horizon 2020.

assistant: **Objectives**

Most maritime products are typically associated with large investments and are seldom built in large series. Where other modes of transport benefit from the economy of series production, this is not the case for maritime products which are typically designed to refined customer requirements increasingly determined by the need for high efficiency, flexibility and low environmental impact at a competitive price. Product design is thus subject to global trade-offs among traditional constraints (customer needs, technical requirements, cost) and new requirements (life-cycle, environmental impact, rules).One of the most important design objectives is to minimise total cost over the economic life cycle of the product, taking into account maintenance, refitting, renewal, manning, recycling, environmental footprint, etc. The trade-off among all these requirements must be assessed and evaluated in the first steps of the design process on the basis of customer / owner specifications. Advanced product design needs to adapt to profound, sometimes contradicting requirements and assure a flexible and optimised performance over the entire life-cycle for varying operational conditions. This calls for greatly improved design tools including multi-objective optimisation and finally virtual testing of the overall design and its components.HOLISHIP (HOLIstic optimisation of SHIP design and operation for life-cycle) addresses these urgent industry needs by the development of innovative design methodologies, integrating design requirements (technical constraints, performance indicators, life-cycle cost, environmental impact) at an early design stage and for the entire life-cycle in an integrated design environment. Design integration will be implemented in practice by the development of integ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Women, integration and prison. an analysis of the processes of socio-labour integration of women in prison in europe.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project poses the challenge of dealing with a common problem in the area of the countries of the European Community: the problem of socio-labor integration of women prisoners, the situation of the prisons throughout the European countries, the development of social and penitentiary policies and their effects in remobilization, the social and penal situation of the socially most vulnerable groups. With the present project we want to cover an area of study that takes in a European dimension setting out from the elaboration of a model of comparative analysis that allows for the elaboration of a framework of common theoretical reflection, an empirical analysis on the reality of the penitentiary populations of women for the elaboration of proposals and policies that will have and impact on the territory of the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PersonalIzed medicine in Chronic KidnEy Disease' in the context of a Horizon Europe call.

assistant: **Objectives**

In 2017, on a world scale the total number of individuals with chronic kidney disease, acute kidney injury, and those on renal replacement therapy exceeded 850 million, a truly concerning figure that is twice the estimated number of people with diabetes worldwide and >20 times higher than the number of individuals affected by AIDS/HIV worldwide. The socioeconomic impact of kidney disease is huge and is anticipated to even further grow in the coming years. Awareness of the magnitude and the risks of this condition have remained low at the population level. Therefore, kidney disease has been, until recently, largely overlooked by health authorities and governments in most countries with as the result accumulation of major unmet needs in personalized medicine in kidney disease. The aim of PICKED (PersonalIzed medicine in Chronic KidnEy Disease) is to equip a generation of 10 doctoral candidates (DC) with interdisciplinary skills for the development of pathways to implement personalized medicine in chronic kidney disease and their complications on the level of its detection, progression and treatment. We anticipate that these DCs will significantly contribute to the increasing possibilities to stratify patients with kidney disease and the development of successful intervention procedures with potential to substantially impact the lives of over 10% of the European population. PICKED will realize this aim by coordinating the efforts of 10 beneficiaries and 8 associated partners across 7 European countries and 3 sectors, with lead supervisors covering a large range of disciplines ranging from biomarker-research to research into the legal, ethical and quality of life aspects for the implementation of personalized medicine in kidney disease.


**Keywords:** chronic kidney diseas