RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'GENomes Evolve in a Landscape of TEs' in the context of a Horizon Europe call.

assistant: **Objectives**

Understanding how genomes work is intimately entangled with understanding how they evolved. Although most individual mutations are single-base, more sequence is changed through structural variation, which itself is in large part driven by transposable elements (TEs), frequently with greater functional and reproductive consequences. Here we will take a multi-pronged and interdisciplinary approach to advance our understanding of how the genomes of multicellular eukaryotes and their TEs co-evolve, building on the near-perfect genome assemblies arriving at an exponentially increasing rate from long-read technologies.We will develop new efficient computational tools that operate at the scale of the data that is coming, and couple them to powerful population genetic, phylogenetic and experimental approaches to study the dynamics of TE invasions in Arabidopsis and Drosophila, the preeminent systems for genetic analysis of TE-host interactions. We will extend “ancestral recombination graph” approaches beyond current models of point mutation and homologous recombination to also support transposition, non-homologous recombination and other forms of structural rearrangement - this will properly account for these processes in a powerful framework for analysis of selection, population history and trait association. We will then apply these tools to two vertebrate systems, the Malawi cichlid fish radiation and the bats, in both of which increased TE activity is seen alongside rapid evolution with remarkable adaptations to phenotype and lifestyle, and will collaborate with others including those generating large Tree of Life genome datasets. The resulting advances will connect top-down genomic sequence analysis with bottom-up mechanistic studies of TE function, via population-genetic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovation Partnership for a Roadmap on Vaccines in Europe' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Under the leadership of the major Europe-based vaccine industry players, IPROVE (Innovation Partnership for a Roadmap on Vaccines in Europe) will produce a comprehensive roadmap on the future of vaccine R&D, production and delivery in the EU. IPROVE aims to drive current EU research efforts towards the establishment of a clear vision of the priority innovations and technologies necessary to address infectious and non-infectious threats of importance not only to global public health, but also to today’s key EU health challenges (e.g. ageing population, healthcare-associated infections, high chronic disease incidence, low levels of prevention awareness, and suboptimal use of existing cost-effective vaccines across the lifespan). The roadmap will explore how the wealth of expertise available across academia, industry, SMEs, public health institutes, and regulatory bodies can be pooled and leveraged to overcome fragmentation and removal of bottlenecks to the timely translation of breakthrough research into innovative vaccines. The project will look at the entire innovation chain, from discovery to delivery, including interventions necessary to improve education curricula, perception and awareness. IPROVE proposes to achieve its goal using a consultation-based stakeholder collaborative process bringing together the key public and private players in the vaccine field in Europe and beyond. This will contribute to understanding the scientific, political and economic potential to be tapped in order to favour a more structured vaccine innovation agenda. The roadmap is expected to inform strategic decisions on the priorities for future vaccine investment at EU and MS level. The exercise is considered key to secure that the EU is capable of tackling changing medical needs and strai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Biomediated calcite precipitation for monumental stones reinforcement (BIOREINFORCE)'.

assistant: **Concept**

Monumental stone decay is due to the interaction between the material and environmental parameters and the consequence is a progressive increasing of stone porosity and weakening of the cohesion of the mineral structures. The sector of monumental repair and maintenance needs of safer and longer lasting treatments. The objective of the project is to introduce in this field innovative techniques for the conservation of calcareous monumental stones with very low environmental pollution. It is based on the use of bio-inducing macromolecules solutions (BIMSs) to growth new calcite crystals inside porosity, reinforcing the stone structure. The Bio-Mediated Treatment (BMT) will be firstly developed and evaluated in laboratory experiments and outdoor conditions, then validated on monumental sites applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Application of graphene based materials in aeronautical structures for de-icing, lightning strike protection, fire barrier and water absorption prevention purposes' (GRAPHICING) under Horizon 2020.

assistant: **Objectives**

In order to improve aircraft efficiency and to decrease fuel consumption and CO2 emissions innovative light weight polymer composite materials with superior mechanical properties for advanced aircraft structures are in development. As an ultimate goal such new lightweight materials should also enable advanced integration of additional functionalities. Current functional aircraft components are designed separately and integrated afterwards. A future advanced integrative manufacturing approach is leading to fewer but also more complex parts with multiple functions resulting in better energy management, aerodynamic efficiency and additional weight reduction. A candidate for the development of advanced functional lightweight materials and systems with the capability for efficient integration in aircraft structures are thermoelectric de-icing systems essential for aircraft safety by avoiding in-flight icing. State-of-the-art systems consist of metal or composite structural aircraft components coated with polymers containing a high amount of graphite and carbon black particles in order to enable sufficient electrical conductivity required for efficient de-icing applications. The high amount of non-polymer particles deteriorates the advantageous mechanical properties of high strength polymers making such systems unsuitable for an integrative approach. In order to realise a future integrative approach structural components can be modified by graphene additives in order to improve electrical and thermal conductivity, toughness/damage tolerance and the formation of an efficient vapor/liquid barrier. It is therefore promising to investigate and develop graphene materials based composites for their potential use in thermoelectrical de-icing, lightning strike protection, fire and wa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced ROV Package for Automatic Mobile Inspection of Sediments' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

ROVs and adapted skids are the new way to collect samples and data especially in deep sea allowing the scientists to increase the scale of the investigation, compared to the one obtained with manned submersibles or towed sleds. However the results achievable with conventional ROV's are greatly conditionned by the manual piloting performance of the vehicle and by the ability of making continuous in situ measurements and multiple sampling of the basic elements. The prime objective of the present proposal is to provide the technology to carry out integrated multidisciplinary seabed research by developing a scientific and technological system, named ARAMIS, which can be easily integrated with typical mid class existing ROVs to form a highly automated and robotised scientific tool for catrying out benthic investigations both in shallow and deep waters. The resulting system (ARAMIS+ROV) will allow the pilot/scientist to easily command in real time both the ROV and the scientific instruments/tools so as to carry out the scientific mission in an efficient, reliable and repeatable way. Main capabilities include:  - scientific: automatic near boKom water physical and chemical profiles, automatic sea water and sediment multiple sampling, physical and chemical sediment profiles, quantitative and dimensional video transects via automatic processing of stereo TV images, visual analysis of sea floor features through automatic image processing techniques  - technological: automatic station keeping, automatic navigation along a transect at a given boKom distance, automatic landing on the sea boKom to take samples, automatic swim around a static target, automatic obstacle detection and avoidance The ARAMIS system (composed of two parts: an underwater skid carrying the scientific instrume
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Of Awful Connections, East German Primitives and the New Black Berlin Wall: Germany and German History in African American Literature, 1892-2016' (GAAL) under Horizon 2020.

assistant: **Objectives**

Darryl Pinckney’s “Black Deutschland” (2016), Paul Beatty’s “Slumberland” (2008), and John A. Williams’ “Clifford’s Blues” (1999) are three recent novels by African American authors and with African American protagonists that are partly set in Germany and that include references to events of German history such as the Holocaust and German Reunification. The research action will take these three novels as points of departure for an investigation that combines an accurate analysis of the images and functions of Germany and German history in African American literature with a transnational, comparative perspective. Drawing on a theoretical framework that connects comparative imagology, black diaspora studies, and the recent academic focus on world literature's “multidirectional memory” and its “cosmopolitan style”, the project will analyze four historically diverse, cross-cultural discourses that have shaped the role of Germany and German history in African American literature: 1) the formation of a ‘canonic’ African American image of postromantic Wilhelminian Germany that can be traced back to Du Bois’ time as a student in Berlin (1892-94); 2) the interwar period and its intertwining sub-discourses of the Old World as “racial haven” for African Americans, and of Berlin as “European capital of sexual libertinage”; 3) National Socialism and its relations and parallels to racism in the U.S.; 4) African American perceptions of Germany as a divided and/or reunified country. The project is based at two institutions in Berlin: the interdisciplinary Zentrum für Literatur- and Kulturforschung (ZfL), where the applicant will be part of the research area on world literature, and the Kennedy Institute for North American Studies at the FU Berlin, where a secondment will take place. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mechanisms of cell cycle exit regulation by the retinoblastoma-related protein p130' (1994-1998).

assistant: **Concept**

The aim of this proposal is to study protein interactions specific of p130 phosphorylated forms occuring upon cell cycle exit, in order to ascertain novel mechanisms that integrate growth inhibiting and/or differentiating signals and that may be involved in cell transformation when altered. The research strategy will consist in the use of different p130 mutants, involving specific protein domains and phosphorylation sites, as baits in yeast two-hybrid screening assays. The cDNA libraries to be screened will be obtained from particular conditions of cell cycle exit where preliminary work indicates a primary function of p130. The characterise of p130 mutants, of the cDNA clones obtained, and the study of cellular interaction of individual p130 phosphorylated forms will provide a mean of ascertaining the precise role of p130 during cell cycle exit. The training objective of this proposal is to complement my previous research formation with the leading experience of the host laboratory in some aspects of the cell cycle field, in order to conduct independent research in the future. The expected results will be instrumental in understanding processes of cell cycle exit, and they may have relevant implications defining novel mechanisms of cell transformation. The host laboratory is linked to the european biotechnology company Prolifix Results arising from this proposal will be used for application in drug design a production if suitable (see Description of the Host Institute).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'New surface modified flame retarded polymeric systems to improve safety in transportation and other areas (FLAMERET)'.

assistant: **Concept**

The extensive use of polymers increases fire hazard. Harmful gases may also evolve at burning causing environmental damage . The integrated activity of universities , research institute , regulatory body , SMEs and user , from two EU countries plus two associated ones , concentrate on development and production of a new high performance recyclable and low-cost halogen free flame retarded product family, demonstration of its applicability in the area of transport and dissemination of the results in various application fields and countries. The innovation includes synthetics, encapsulation of flame retardant particles, formation of nanocomposite structure and of nano - sized protective layer, which can be applied in advanced reactive manufacturing processes of flame retarded extended lifetime interior vehicle elements and other products of increased safety . Improvement is expected in safety, cost, recyclability, toxicity and lifetime.Main technical achievements of the project are as follows:· synthesis of new and surface modified FLAMERET additives, 2 types of which were utilized by flame retardant producer companies,· preparation of polymer granulates sheets, textiles, 5 types of which were manufactured on industrial scale,· elaboration of a new, recyclable, economic, halogen-free FLAMERET products (like dashboard, a complete seat, other injection moulded articles, decorative textile and a fire barrier nonwoven back layer), which were processed by the SME type partners and in some of which the increased level of fire safety is combined with sound insulating character,· elaboration of proposals for new, improved standards taking into account smoke emission, toxicity, corrosiveness, etc. because the currently required fire resistency in buses and cars is far from the safe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Definition of the chemical and immunological characteristics of flucloxacillin-induced liver injury' (Chic-FILI).

assistant: **Concept**

Immunological reactions represent one of the most feared adverse drug events; they cannot be predicted and show no simple dose-response relationship. The presence of drug-response T-lymphocytes in patients with cutaneous reactions provides a robust case for their involvement in the disease pathogenesis. In contrast, the role of T-cells in reactions targeting the liver is less well defined.We have recently defined the profile of drug protein conjugation at specific amino acid residues with respect to dose and incubation time and characterized the minimum levels of modification associated with the stimulation of T-cells. We now aim to utilize these methods to characterize the cellular response in patients with flucloxacillin-induced liver injury. Drug antigens will be characterized by mass spectrometry and used to define the phenotype (CD, homing receptors) and function (Th1, Th2, Th17 & cytotoxicity) of antigen-specific T-lymphocytes and T-cell clones.Recently, an association between expression of HLA-B*5701 and flucloxacillin-induced liver injury has been described, which implies a direct effect of the gene product on the disease pathogenesis. To explore whether susceptibility relates to the restriction of the fit of the drug antigen in MHC, we will utilize our unique cell bank of HLA-typed healthy volunteers and a novel in vitro assay to relate phenotype to function and to investigate the additional signals that might be required to convert an antigenic signal into an aberrant T-cell response.The Fellow will be trained in bioanalytical and cell culture methods that are directly applicable to immunological drug reactions. Furthermore, the Liverpool CDSS and the Ajou School of Medicine will establish a collaboration to transfer clinical samples to investigate other HLA a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New Approaches to Metallo-β-Lactamase Inhibitors' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The increasing problem of antibiotic resistance is a major global public health concern. In the EU 25,000 patients die each year due to infections caused by multi-resistant bacterial pathogens, and the EU spends at least 1.5 billion euro per year on healthcare costs. The β-lactam antibiotics are the most important antibiotics representing >60% of small molecules in clinical use. BLAs contain a β-lactam ring which is critical for penicillin-binding protein inhibition. However, BLA efficacy is declining due to resistance mechanisms including the widespread occurrence of β-lactamases, which catalyse β-lactam hydrolysis. Metallo-β-lactamases, long-considered as of little clinical relevance, now present a serious global threat to almost all BLAs, rendering the development of approaches to MBL inhibitors important. Unlike the serine β-lactamases, the MBLs are structurally and mechanistically unrelated to PBPs, and are not inhibited by current mechanism-based SBL inhibitors. Due to variations in MBL structures, a major challenge in MBL inhibition is the development of compounds with the breadth of selectivity necessary for clinical utility. Society is now in an alarming situation and there is a clear need for the development of an MBLI:β-lactam-based combination therapies. The aim of my proposed work is to pioneer, enable and inspire the generation of broad-spectrum MBLIs active against a panel of clinically representative MBLs, but inactive against human enzymes with related active sites. To obtain the desired objective, novel approaches are proposed and include the use of phosphonates and phosphinic acids for: (a) MBL-directed DCC coupled to analysis by non-denaturing ESI-MS and 31P-NMR, (b) 31P-NMR reporter screening method, (c) pre-equilibrated DCLs for MBL-directed DCC, a