RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'encrypted storage device for classified information KOBRA Drive / KOBRA Stick' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In recent years, the growth of hacker and cyber-attacks has significantly increased. As a result of growing threats European Commission, European Council and European Parliament decided to step up their cyber security efforts by reinforcing the new EU cyber security law. The new European GDPR places high demands on the collection and storage of personal data of individuals by public agencies and companies.Authorities and companies’ process data containing sensitive or confidential information. This information may only be stored on authorized media. Currently, there are no external data carriers in the EU or worldwide, which are approved by the BSI being suitable for clearance level such VS-NfD(classified information for official use) or higher. Furthermore, within the EU there is an increased use of PKI (Public-Key-Infrastructure)-based smart cards by government agency and businesses as company ID for the purpose of secure authentication as well as execution of various internal processes and tasks.There are already a few manufacturers of encrypted USB Drives on the market, predominantly based in the US or China. Their products are however not suitable for sensitive data with confidential levels such as VS-NfD or higher. Furthermore there is no solution on the market that allows data carriers to unlock with company IDs.The innovation of DIGITTRADE solves these problems and is called encrypted storage device for classified information KOBRA. It unites two products of new generation: external encrypted hard drive ESDCI KOBRA Drive and the encrypted USB-C stick ESDCI KOBRA Stick. These data carriers are easy to use and can be activated with existing company ID cards.Since its founding in 2005, DIGITTRADE has been involved in the development and production of encrypted data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Regulation of breast cancer invasion and metastasis by the non-receptor tyrosine kinase Pyk2'.

assistant: **Innovation**

Metastatic spread of cancer cells to other tissues and organs is the primary cause of mortality from breast cancer. Metastatic cancer cells invade surrounding tissues and blood vessels by forming F-actin rich protrusions called invadopodia that degrade the extracellular matrix and enable invasion through it. A major challenge in breast cancer research is to elucidate the mechanisms that underlie invadopodia formation and function. The non-receptor tyrosine kinase Pyk2 is highly expressed in invasive cancers, but the signaling mechanism through which Pyk2 regulates invasion and metastasis are largely unknown. This proposal aims to understand whether and how signaling via Pyk2 regulates invadopodia formation and function in metastatic breast cancer cells. Our first goal in the proposed research would be to determine whether and how the integrin-Pyk2-Src axis drives invadopodial protrusion and invasiveness in breast cancer cells. Following elucidation of the role of Pyk2 in invadopodia, we will compare the similar or differential roles of Pyk2 vs. FAK in Src localization and in invadopodia regulation. Using a high throughput proteomic approach utilizing purified proteins, we will then explore additional substrates and interactors of Pyk2 in invadopodia, in order to elucidate new signaling pathways in which the kinase is involved. Following the experiments described above, we will use mice models combined with cutting-edge single cell resolution intravital imaging of mammary tumors in mice, in order to verify the effect of Pyk2 on invadopodia regulation and cancer metastasis in vivo. The proposed research aims to elucidate the molecular, cellular, and whole organism mechanisms that contribute to the tissue invasiveness and metastatic potential of breast cancer cells. We hop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SMART MODULAR UNDERFLOOR HEATING SYSTEM FOR ENERGY AND THERMAL COMFORT OPTIMIZATION' in the context of a Horizon 2020 call.

assistant: **Objectives**

Large portion of buildings energy consumption from space heating is wasted. Poor indoor temperature control, low heating energy efficiency or lack of insulation are the main causes of the energy loss. This is critical in cold climate office buildings where space heating consumption accounts for up to 50% of the yearly building energy consumption. Moreover, indoor environmental and personal factors (thermal comfort), are strongly linked to energy efficiency in buildings and to productivity of occupants. Combined  energy-comfort approaches in space heating are needed in order to guarantee high indoor environmental quality and energy efficiency. To meet this challenge,  integration of the Internet of the Things and space heating technologies for buildings represents a huge business opportunity still not exploited in terms of energy savings from higher comfort levels.Overall objective of PLACTHERM is to accelerate the market uptake of PlacTherm®, a smart modular underfloor heating system based on Exploded View patent pending technology that fully merges underfloor heating (UFH) and Internet of the Things technologies in a stand-alone solution.PlacTherm® enables buildings to achieve maximum energy savings and indoor comfort levels by untapping the benefits from having one single room covered by over 200 single temperature and pressure sensors and heating sources, enabling each occupant to have their own temperature of comfort, and reducing the energy for heating empty areas.PLACTHERM will generate impact at different levels:- society: lower environmental impact from the buildings- economic performance of the energy bill payers- health of building occupants: increase in their thermal comfort/wellbeing at their workplaces and consequently increasing their productivity- Explode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Targeted Probes and Nanoparticles: Advancing Host-Driven Clearance of Recalcitrant Bacterial Pathogens' in the context of a Horizon Europe call.

assistant: **Objectives**

Antimicrobials are the cornerstone of modern medicine, essential for treating millions of people worldwide. Without effective antibiotics, even minor surgeries and routine operations could become high-risk procedures due to untreatable infections. Antimicrobials save lives and contribute, on average, 20 years to global life expectancy. However, the overuse of these drugs and the emergence of antibiotic-resistant bacteria are severely diminishing their therapeutic effects, making treatment increasingly difficult or even impossible. This phenomenon, known as antimicrobial resistance (AMR), is a growing health crisis that threatens to undermine the foundation of medical treatment that doctors, patients and public have come to rely on. Currently, an estimated 4.95 million deaths per year are associated with drug-resistant pathogens, with 1.27 million directly attributed to bacterial pathogens resistant to existing antibiotics. Hence, to address this urgent health challenge, new strategies are critically needed to contain, control and mitigated the spread of AMR. In this respect, BactErase proposes a novel host-directed therapy that leverage the natural ability of resident macrophage to utilize macroautophagy - a process that cells use to degrade and recycle intracellular components - to eradicate intracellular invaders. The primary goal of this proposal is to develop a bacteria-specific probe that can uniquely discriminate the bacteria within the cells and to design nanoparticles preferentially targeting infected cells. This approach aims to enhance the host’s intrinsic ability to resolve drug-recalcitrant infections while minimizing the risk of antimicrobial resistance development. By exploiting the host’s own mechanisms for bacterial clearance in conjunction with selectiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulatory networks of plant cell rearrangement during symbiont accommodation' to be submitted under Horizon 2020.

assistant: **Abstract**

Arbuscular mycorrhiza (AM) is an ancient plant-fungus symbiosis that is wide-spread in the plant kingdom. AM improves plant nutrition, stress resistance and general plant performance and thus represents a promising addition to sustainable agricultural practices. Mineral nutrients are released from the fungus to the plant at highly branched hyphal structures, the arbuscules, which form inside root cortex cells. Like the cells of other multicellular eukaryotes, plant cells show a remarkable developmental plasticity. Single cell re-differentiation is a fascinating process during arbuscule development, which can be conceptually separated into distinct stages controlled by the plant cell which precisely guide the step-wise formation of different parts of the arbuscule. It involves cell autonomous transcriptional reprogramming and subcellular remodelling, leading to repositioning of subcellular structures, cell polarization and multiplication of organelles. It is currently unknown how cell-autonomous reprogramming during arbuscule development is regulated. RECEIVE utilizes an integrated strategy combining transcriptional profiling, transcription factor identification, interaction network analysis with reverse genetics and cell biological techniques to understand the coordinated step-wise progression of arbuscule development. RECEIVE builds on the hypothesis that each stage of arbuscule development is accompanied by a stage-specific wave of gene expression and that transcriptional regulation is a key determinant of the developmental progress from stage to stage. The characterisation of these waves and the identification of the underlying transcriptional regulatory nodes is the focus of this project. RECEIVE aims to bridge a major knowledge gap about the molecular basis of one
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TRUSTWORTHY AI FOR IMPROVEMENT OF STROKE OUTCOMES' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

TRUSTroke proposes a novel trustworthy by design and privacy-preserving AI-based platform to assist clinicians, patients and caregivers in the management of acute and chronic phases of ischemic stroke, based on the integration of clinical and patient-reported data, outcomes and experience for a trustworthy assessment of disease progression and risks. enabling more personalised and effective management of stroke, as well as providing inter-hospital benchmarking and sharing best practices. Specifically, TRUSTroke will address to risks of: i) clinical severity at discharge ii) clinical worsening leading to unplanned hospital readmissions, iii) poor mobility, incomplete recovery and unfavourable clinical long-term outcomes; iv) stroke recurrence.To this purpose, a Federated Learning infrastructure will enable multiple clinical sites to build several trustworthy AI based predictive models by leveraging stroke data without compromising privacy and implementing best-in-class security and privacy protocols. FAIRified clinical data from leading European hospitals and outpatient monitored data from a remote home-care system, will be used (i) to train and validate trustworthy AI models for stroke prediction; (ii) to personalise patients´ assessment of cardiovascular risk factors, treatment compliance and communication with healthcare professionals. TRUSTroke platform will be trustworthy by design since it will be compliant with the recognized guidelines for building FAIR resources and trustworthy AI systems, including the need for transparency, explainability, robustness, accountability, accuracy and security of the learned AI models. A series of User Experience studies will be performed to increase the usability of the platform and improve the communication to the end-users. A fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'StUDY OF THE NOVEL ENERGY SAVING PROCESS FOR THE MANUFACTURE OF INDUSTRIAL PRESSURE VESSELS' (1994-1998).

assistant: **Concept**

Current industrial pressure vessel manufacturing technology uses large quantities of steel involves an extra internal heating/cooling structure and results in a very heavy final product. The study will aim to increase process safety: reduce process material costs by up to 50 %: reduce energy consumed by up to 50 %: indirectly reduce the pollution and waste by up to 50 %: and reduce the cost of industrial pressure vessels by up to 30 %. The RTD goals to meet these aims are: reduce the thickness of steel used in the outer skin: Strengthen the outer skin by using an embossed structure: eliminate the use of an extra internal heating/cooling structure; utilise the new outer skin structure to enable healing or cooling in the vessel; generate a computer programme that predicts the pressure characteristics of industrial pressure vessels manufactured in this novel way. It is intended to do this by the study of a novel process for the manufacture of industrial pressure vessels, in an energy saving way.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ubiquitous Personalised Interactive Multimedia TV Systems and Services' (UP-TV) targeting Fifth Framework.

assistant: **Abstract**

The interactive time independent access to broadband multimedia information is not supported using today's networks and client systems. The idea of TV Anytime is based on the local caching of broadband media streams and allows in this way an interactive and time independent access to this information. The major objective of the UP-TV project is the development of basic technologies for scalable TV Anytime systems that implement personal TV services for business and consumer applications. The UP-TV project develops basic technologies on the one hand but also integrates two demonstrator applications and trials them in real-world environments.Objectives:UP-TV is an integrated research and development project developing basic technologies for TV Anytime systems and services. The research questions targeted in this project focus on the identification of media content that has to be recorded, the placement of those media assets onto single and networked media servers as well as the organisation of an efficient and comfortable access to these assets. The results of these research work influence the development of a TV Anytime server system that allows to support a scalable number of users, ranging from a cost-efficient consumer system to a large scale server system. Based on a general service platform, two application scenarios that integrate TV Anytime scenarios and web applications are implemented and tested. The application study personal TV in hotel environments and hierarchical wide area networks. The technical work in UP-TV is accompanied by preparation of business plans for the role out of personal TV services.Work description:The work within UP-TV is partitioned in four major tracks. There is work on basic research for relevant technologies for TV Anytime system, work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Simulation of Cardiac Devices & Drugs for in-silico Testing and Certification' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Despite massive investment in healthcare, huge R&D cost increase and regulatory pathway complexity hamper tremendously commercialisation of new devices & medicines, putting patient populations at risk of not receiving adequate therapy. At the same time, outside healthcare, computer modelling and simulation (CM&S) is precisely recognised to increase speed & agility while reducing costs of development. CM&S can create scientific evidence based on controlled investigations including variability, uncertainty quantification, and satisfying demands for safety, efficacy & improved access.Cardiac modelling has dramatically gained maturity over the last decades, with personalisation to clinical data enabling validation. We selected a number of cardiac devices and medicines where CM&S is mature enough and that represent the most common cardiac pathologies, to demonstrate a standardised and rigorous approach for in-silico clinical trials. SimCardioTest will bring a disruptive innovation by creating an integrated and secure platform standardising & bridging model simulations, in-silico trials, and certification support. This environment will go beyond the state-of-the-art in computational multi-physics & multi-scale personalised cardiac models. Diseased conditions and gender/age differences will be considered to overcome clinical trials limitations such as under-representation of groups (e.g. women, children, low socio-economic status). Advanced big data, visual analytics & artificial intelligence tools will extract the most relevant information.It is critical that Europe demonstrates its capacity to leverage in-silico technology in order to be competitive in healthcare innovation. SimCardioTest exploitation aims at delivering a major economic impact on the European pharmaceutical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Spatial memory and brain activity - a magnetoencephalographic - meg - and electroencephalographic - eeg - study' (1994-1998).

assistant: **Concept**

Research objectives and content i Aim of this project is to examine how the brain keeps up to date the self-to-environment spatial relations during whole-body displacements. Therefore the brain activity preceding behavioral responses for indicating changes in either location or orientation will be recorded. Specific contributions will be revealed, respectively, by using blindfolds, by including patients with focal brain lesions impairing topographic memory and by performing real and imagined self-motion experiments. During a guided locomotion without vision subjects will direct their attention either toward the surrounding scene or their trajectory. Once reached the new vantage point, brain activity concomitant to the mental updating of self-to-environment spatial relations will be recorded using a 64 channel EEG as well as behavioral parameters (reaction times and en-ors). Investigation of the effect of attentional resources allocation on the updating of the location and orientation of a previously viewed object in space will be performed. MEG, EEG, as well as performance measurements will also be acquired during the internal simulation of a self-to-environment reorientation. Given an initial virtual scene, subjects will determine if a test scene corresponds or not to a to-be-imagined either environment- or subject-relative perspective change. Accordingly, the role of reference frames and visuo-motor imagery when updating spatial information in the temporary absence of vision will be quantified. Training content (objective, benefit and expected impact) The TMR fellowship will allow me to complete my training in cognitive neuroscience by acquinng skills in cognitive electrophysiology, especially using MEG equipment, and then possibly transfering this knowledge to instit