RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Sleeping Embryo' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The implantation of the blastocyst into the uterine wall is a key step of the reproductive cycle, which mediates the connection of the embryo to the maternal tissues during the early stages of pregnancy. However, in some species, including the house mouse, this process can be put on hold, while the embryo falls into a reversible state of suspended animation, known as diapause. The dormant embryos can reside in a “deep sleep” over extended periods of time (e.g. bypassing unfavourable environmental conditions), without compromising their developmental potential. Although, the maternal hormonal control of implantation and the process of transient mouse embryogenesis have been intensively studied, the embryonic diapause is still an extremely enigmatic state. Several lines of evidence, based on my preliminary data, suggest that diapause is not a stasis, but instead is a dynamic process with underlying mechanisms that can appear redundant during transient embryogenesis. Here I aim to decipher the cryptic embryo-intrinsic mechanisms of embryo dormancy, using the mouse as a model system. I will elucidate the cellular processes that coordinate and capacitate the embryo for diapause on epigenetic, transcriptional and cell signalling levels. Using interspecies chimeras and blastoids, I will extend my analysis to non-diapausing species and artificial embryo-like structures. Thus, by manipulating the flow of embryogenesis, I will uncover hidden, dormant mechanisms, safeguarding the developmental potential of the early mammalian embryo.


**Keywords:** embryo dormancy, diapause, blastocyst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Transition from Transport Reindeer Herding to Reindeer Pastoralism: A study of Indigenous Governance during Change' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Aboriginal societies around the world have independently transitioned their production mode. In northern Eurasia, the transition manifested itself in a movement away from transport reindeer herding towards reindeer pastoralism from the sixteenth to nineteenth centuries. Although this was one of the most significant changes affecting circumpolar people across the region, much remains unknown about the drivers of this transition, and even less about its consequences for indigenous governance and social relations. Northern Fennoscandia was one of the first regions to witness the transition, and the indigenous Sami of northern Sweden are an especially suitable case for addressing these gaps.The historical sources are exceptionally rich and Sami are a very interesting case because reindeer pastoralism developed in a foraging culture, with many households continuing as hunters and fishers even after the transition dominated society. A central assumption is that the transition to reindeer pastoralism was induced by market opportunities. TransRein builds on the hypothesis that the transition of these societies was driven by concomitant, self-governed responses as the transition progressed and will advance research about indigenous reindeer-herding societies beyond the state of the art by pursuing the following three objectives.1. Create a detailed depiction of the transition from transport reindeer herding to reindeer pastoralism among indigenous Sami, focusing on governance of natural resources and—for the first time—its effect on social relations, and significantly deepen our understanding of indigenous governance, 1550–1800.2. Identify common forces behind the transition through comparisons with other reindeer-herding societies in Eurasia that underwent the same transition.3
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel First-in-Class Specific Oromucosal Immunotherapy (SOMIT) to treat Celiac Disease (CD)' under Horizon Europe.

assistant: **Concept**

Celiac disease is an autoimmune indication for which there is no cure. Only the life-long avoidance of the disease causing gliadin protein in gluten is available as a sub-optimal and cumbersome necessity for CD patients. We developed a unique novel combination of antigen (gliadin protein), probiotic tolerogenic bacterial particles (TBPs) and mouth patch technology to enhance the bioavailability and tolerance induction. Synergistic tolerizing properties of the TBP-antigen combination and the therapeutic effect of the SOMIT concept has been shown in a suitable pig model. Our SOMIT-CD promises to require a short-course weekly treatment for less than 3 months in CD patients.This EIC project will allow us to finalize the various preclinical activities and perform phase Ib/IIa clinical study, paving the way to closing a co-development deal with a big pharma player.After market entry in 2029, we aim to reach a market share of 15% and generate annual revenues of 148M by 2033.


**Keywords:** Autoimmune disorders,Oralmucosa,Mouth patch,Celiac disease,Immunotherapy,Tolerizing effect,Antigen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'LEAF: heaL thE plAnet's Future' under Horizon Europe.

assistant: **Concept**

Starting from the encouraging results of the LEAF (heaL thE plAnet's Future) project in 2022 and 2023 NIGHT edition, we are now proposing a step forward to increase the awareness on the importance of research and innovation, to improve trust in the researcher's work by effectively involving the society in experimenting science through 900 events. All activities will cover EU Green Deal topics (Farm to Fork, Biodiversity, Circular economy, Zero-pollution, toxic-free environments, Health & Wellbeing, Energy and resource efficient buildings, secure energy, sustainable and smart mobility). The main goal is to make science accessible and fun to everyone, thus generating a practical understanding of how to cope with climate change issues. The LEAF project will be developed in 20 cities in Italy, involving 43 partners, 6 of which as Associated, with a series of events happening during the last week of September 2024 and 2025 thus including the NIGHT. LEAF 24-25 project will include a series of specific activities dedicated to schools to permit researchers to engage with teachers and pupils on challenges related to climate change, sustainable development, health and other issues related to the European Commission priorities such as the European Green Deal. In particular, in this edition we will reinforce the experience at school involving institutes located all around Italy and in particular in small towns with difficulties in reaching NIGHT events. First year will be devoted to fulfill the achievements reached in last editions while in 2025 our main goal will be the improvement of project KPIs thanks to the validation of the Researchers@Schools activity. The overall result will be a relevant increase in the awareness of why and how the researcher's work is relevant for the ben
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'How do groundwater-surface water interactions control recharge from ephemeral streams?' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The aim of this Fellowship is to develop the first detailed process understanding for how groundwater-surface water interactions (GSI) control indirect recharge in ephemeral stream catchments. Such research is urgently needed to underpin sustainable water resources management in the context of global change.  A multidisciplinary approach will be taken to integrate innovative and detailed field monitoring and analysis of a study catchment in New South Wales (NSW), Australia, with state-of-the-art numerical modelling techniques to derive process understandings transferable to other catchments. The sensitivity of groundwater recharge to future scenarios of changing landuse, climate and groundwater abstraction will be assessed. The Fellow, Dr Mark Cuthbert, shows exceptional promise in becoming a leading scholar demonstrated by a wide range of publications in highly ranked journals, involvement in collaborative research projects, and strong leadership and project management skills. He will be based for the first 2 years of the Fellowship at the University of NSW, focusing mainly on field aspects of the research and training. He will benefit from working with internationally leading scholars in GSI research and have access to a unique range of world-class equipment, catchment infrastructure and technical expertise. Returning to the EU to work with the University of Birmingham, modelling components of the research will be developed, supported by the facilities and groundwater-surface water expertise within the internationally excellent Water Sciences research group. In addition to the fundamental scientific research, the Fellow will receive training in a range of field, analytical and modelling techniques as well as complementary research skills.  The Fellowship will enable h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Searching for SuperSymmetry at LHC: Study Program with ATLAS at CPPM Marseille' (ATLAS-CPPM-SUSY).

assistant: **Innovation**

The ATLAS experiment has the ambitious goal to look for and understand the origin of mass in our world. The detector will search for new particles in the collisions of protons provided by the Large Hadron Collider (LHC) at the European Laboratory for Particle Physics (CERN) in Geneva. This accelerator will open, in 2007, a new energy window in particle physics and new phenomena beyond the Standard Model, like super-symmetric particles, are expected tomanifest themselves in the ATLAS detector.The search for super symmetry will be actively pursued and requires a thorough preparation work, which has to start now. One of the biggest challenge to extract this physics is the unprecedented amount of computing power, storage capability and network bandwidth needed to treat the LHC data, for which grid computing is being developed. The CPPM (Centre de Physique des Particules de Marseille), the host-organization, is strongly involved in grid computing development, through its local EGEE group, and is part of the ATLAS project since its inception.TheATLAS group has a leading role in different key-parts of ATLAS:electro magnetic calorimeters, pixel detectors for tracking and event filter for trigger. The group is already involved in preparation work for physics: top quark studies, searches for the Higgs boson. By strengthening and building up on these competences in CPPM, this project aims to extend the field of investigation to cover searches for super symmetric particles.Complementary to the physics studies already performed at CPPM, this project greatly enhances the CPPM range of physics investigations and its visibility in the particle physics community. Large-scale simulations on the computing grid are an essential part of this proposal with close interactionwith the EGEE/CPPM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '5G-TRANSFORMER: 5G Mobile Transport Platform for Verticals' (5G-TRANSFORMER).

assistant: **Innovation**

The vision of the 5G-TRANSFORMER project is that Mobile Transport Networks shall transform from today’s rigid interconnection solutions into an SDN/NFV-based 5G Mobile Transport and Computing Platform (MTP) able of simultaneously supporting an extremely diverse range of networking and computing requirements to meet in particular the specific needs of vertical industries. A new networking paradigm known as Network Slicing has emerged for 5G as the most promising approach to address this challenge by enabling per slice management of virtualized resources. 5G-TRANSFORMER aims to bring the “Network Slicing” paradigm into mobile transport networks by provisioning and managing MTP slices tailored to the needs of vertical industries. Specifically: automotive, healthcare and media. The technical approach is twofold: (1) Enable Vertical Industries to meet their service requirements within customised MTP slices; and (2) Aggregate and Federate transport networking and computing fabric, from the edge up to the core and cloud, to create and manage MTP slices throughout a federated virtualized infrastructure. The proposed solution defines three novel building blocks that will be developed and demonstrated integrating the aforementioned three vertical industries:(1) Vertical Slicer as the logical entry point (i.e., one stop shop) for verticals to support the creation of their respective transport slices in a short time-scale (in the order of minutes).(2) Service Orchestrator to orchestrate the federation of transport networking and computing resources from multiple domains and manage their allocation to slices.(3) Mobile Transport and Computing Platform as the underlying unified transport stratum for integrated fronthaul and backhaul networks.The 5G-TRANSFORMER project addresses “ICT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A CIRCULAR ECONOMY APROACH FOR THE VALORIZATION OF ORANGE PEEL WASTE TO ESTABLISH FOOD SAFETY' (WASTEtoSAFETY) under Horizon Europe.

assistant: **Objectives**

Food safety and food waste management remain two major challenges in Europe, with enormous effects on the economy, the environment and public health. Each year 23 million cases of foodborne illness and 5000 deaths are reported in Europe. At the same time, one third of food produced for human consumption is wasted because it is considered unfit for consumption, which amounts to approximately 1.3 billion tons each year. Therefore, the development of innovative measures to reduce food waste presents a viable alternative in a situation where new solutions are desperately required. In this sense, the development of circular economies that revalorize byproducts and residues of food industries as products that can be reused is a promising research avenue.WASTEtoSAFETY will confront this challenge by developing the scientific basis to implement a circular economy that uses waste from the citrus industry to extend the shelf life of fresh produce from the Mediterranean area. Namely, it will optimize two “green” methods (microwave & ultrasound) for the extraction of essential oils (EO) from orange peel. The EO will be used as the basis for two food preservation technologies: a washing solution and an active packaging. The project will also evaluate their potential impact on the food chain, through a quantitative microbiological risk assessment (QMRA), a Life Cycle Analysis (LCA) combined with a Material Flow Analysis. WASTEtoSAFETY will thus provide tangible advances to the field of Food Science, developing a noticeable solution for the revalorization and utilization of citrus waste. It will also open new research avenues related to the upscaling of these technologies to an industrial level.


**Keywords:** natural antimicrobials,  essential oils,  active packaging,  bacterial dec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Frontiers in Catalytic Anion-Binding Chemistry' to be submitted under Horizon 2020.

assistant: **Abstract**

Chemical transformations comprise the polarization of the reacting species. As a consequence, partially or fully charged reagents and intermediates are omnipresent in chemistry. Although anion-binding processes are well-known for their crucial role in molecular recognition, this type of phenomenon has only recently been utilized for catalysis. Since catalytic reactions are of utmost relevance to construct valuable chemicals and materials, this mode of catalytic chemical activation might be the key for the future design of original and more efficient synthetic transformations. However, the effects of anions in catalytic processes are still largely unknown. Aiming at providing a novel general synthetic toolbox, in this project I propose several anion-binding activation concepts to solve current challenging catalytic synthetic problems. To achieve this goal, structurally different chiral anion-binding catalysts will be developed and incorporated into the existing limited palette of catalyst library. Furthermore, I propose a significant expansion of the application scope of anion-binding catalysis based on the activation and modulation of anionic nucleophiles and oxidants to develop organocatalytic reactions such as halogenations and oxidations, including the asymmetric functionalization of C-H bonds. In addition, anion-binding processes will be used to facilitate key steps in cross-coupling reactions such as the transmetallation, as well as the photoactivity modulation of readily available photosensitizers and the introduction of asymmetric photocatalysis involving radical-anions.The proposed groundbreaking approaches will revolutionize not only anion-binding catalysis but also all the scientific areas relying on catalytic synthetic methods. Thus, the results derived from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of heavy duty reactor window for industrial scale removal of NOx and SO2 from flue gas by electron beam treatment' (1994-1998).

assistant: **Innovation**

Foreseen ResultsSuccessful realization of the project will allow to implement a new-generation of heavy-duty process vessel windows H for the Electron Beam Dry Scrubber Process, first at the Pomorzany Power Station and then in other installations of this type in Europe.Further challenge left for surface engineering scientists will be to reduce the window thickness. As the project addresses the environmental problems it is of importance in european dimension.High emissions of SO2 and NOx from fossil fuel combustion create a major environmental problem all over the Europe. One of the most perspective methods of these pollutants removal is the Electron Beam Dry Scrubber Process, in which the flue gas is treated by high-power, high-energy electron beam. The final product obtained in this process can be used as a fertilizer.In Poland, a pilot industrial installation utilizing this process with a throughput of 20.000 Nm3/h has been built at Kaweczyn Power Station in Warsaw to study and develop this process. Another one, designed for treating of 270.000 Nm3/h of flue gases in under construction at Pomorany Power Station near by Szczecin.The electron beam enters the process vessel through a 50mm thick Ti window. At present, the lifetime of this window is 500 - 2000 h before it fails as a result of corrosion and fatigue. For full industrial implementation the window lifetime should span over the installation overhauling period. The objective of the project is to develop a technology of preparing the window of the desired lifetime. This goal is planned to be accomplished by alloying the window surface with palladium which is known to inhibit Ti corrosion in acidic environment. The alloying will be performed either by ion-beam mixing technique known to be thus far the most effecti