RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Legal Technical Framework for Privacy Preserving Data Management' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Privacy and data protection are of concern to many stakeholders, including the data subjects (end-users), the data controllers (organisations) as well as legislative bodies, data protection agencies, consumer rights organisations and human rights advocates. End-users require assurances that their personal data is being fairly and correctly collected and managed for purposes for which they, ideally, have given explicit consent and is done so in a transparent manner. Organisations collecting personal data need to ensure that the data management practices employed are in compliance with legal requirements and not subject to misuse by its employees. These data protection requirements introduce an overhead (both financial and operational). For european SMEs, the need to ensure compliance can lead to a disproportionate cost when compared to core activities, inhibiting growth and opportunities in competitive global markets.<br/>What can help is an open source toolset which allows organisations to ensure that their personal data management policies are compliant with the appropriate legislation.<br/>ENDORSE will bring together a consortium of data protection legal experts, academic computer science partners, software implementors and interested industry players. The project will produce a privacy rule definition language which will be used to express the appropriate European directives together with national legislative implementations. The language and these legislative instances along with the toolset to create legally compliant privacy policies will be released as open source. A set of open source technology adapters will take these policies as input and produce access control specifications for deployment in the organisations infrastructure. Two industry players will perfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spectroscopy and warming potentials of atmospheric greenhouse gases' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To determine the spectral absorption cross sections in infra-red bands of several HFCs and perfluorinated hydrocarbons under simulated atmospheric conditions, and then to use the spectral data in calculations of the contribution to climate radiative forcing by these gases. Where adequate atmospheric lifetime data exist the calculations will be extended to include estimates of global warming potentials. The spectral absorption cross sections will be established in the laboratory using state of the art Fourier  transform absorption spectroscopy and line by line simulations. Molecules to be studied are HFC-125,  HFC-143a, HFC-32, HFC-134a, HFC-152a, HFC-23, perfluoroethane, perfluorocylobutane, chloroform and  1,2 - dichloroethane. Spectral measurements will be made over a range of temperatures, pressures and mixing  ratios in air which are representative of the physical conditions pertinent to these molecules in the atmosphere.  All infrared bands of relevance will be characterized at relatively high spectral resolutions.  Sophisticated radiative transfer codes will be used to calculate the radiative forcing (change in average net  radiation at the top of the troposphere) of the climate due to these molecules. Where adequate data on the  atmospheric lifetime of these molecules exist, their likely global warming effects will also be estimated. The  radiative transfer codes employed are implementations of both medium resolution band models and high  resolution line by line models. Effects of the representation of spectral structure and spectral overlap with other  absorbing gases (such as H2O, CH4 and N2O) will be studied, as will the effect of degrading the spectral  resolution of the calculations to those typically used in climate change studies using Global Circulation M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Neurobiology of Magnetic Orientation in Mammals' (NeuroMagMa) targeting Horizon 2020.

assistant: **Abstract**

Many animals use the Earth’s magnetic field for orientation, but the sensory cells and molecular mechanisms of the magnetic sense remain a mystery. I propose to tackle this fundamental problem in sensory biology with a top-down approach that exploits state-of-the-art methodology to unravel the neural circuits underlying magnetic orientation. To take advantage of the knowledge and toolkits available for rodent brains I chose a rodent model organism: Mole-rats, which navigate through a maze of underground tunnels for their entire life in total darkness. Their magnetic sense is well established and they can be bred in the laboratory.My project has three ambitious aims: (1) the identification of brain regions that process magnetic stimuli, (2) the discovery of the primary receptor cells, and (3) the characterization of magnetic inputs into head direction cells.Aim 1: Modern tissue clearing techniques allow rendering brains transparent to analyse them in toto. We couple iDISCO brain clearing with the detection of immediate early genes to create a global map of the mole-rat brain regions that process magnetic fields. Aim 2: We make use of the circuitry discovered in Aim 1 to deduce the locus of the magnetoreceptors. Combining neuronal tracing with high-sensitivity imaging methods to detect of magnetite, we will meticulously search for the magnetoreceptors in peripheral tissues.Aim 3: We will establish the first single-unit recordings in freely moving mole-rats. How do head direction (HD) cells function in an animal without access to visual landmarks? My hypothesis is that the HD signal in the mole-rat brain encodes magnetic directions. We will test this by recording from brain areas identified in Aim 1 under different magnetic conditions. Can we discover the first mammal magn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative Open-Source Platform for Seamless Healthcare Device Marketing and Configuration' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The CareStore project wishes to create a shared and open marketplace, similar to Apple’s App Store, for easier deployment of applications and device drivers within the healthcare domain. We wish to extend and adapt existing open source assisted living platforms for nursing homes to integrate the CareStore. These will be investigated and extended with a reliable and secure recognition and identification hardware and software platform to work in a Pan-European context.The envisaged solution is considerably more flexible, cost-competitive and efficient than current state-of-the-art solutions. The CareStore will allow private and public organisations and institutions to select independent vendors and combine hard- and software from several providers. The solution allows nursing homes (via their public or private provider) to establish an independent CareStore through the general setup of the already existing Open-Care based Sekoia platform.Today, a large number of assisted living technologies coexist without a common language between them. They have different user interfaces, communication infrastructures and maintenance plans, which limit the inclusion of efficiency-enhancing solutions in the homecare and elderly sector. The deployment of applications and devices are overly complex, and cannot be handled by healthcare staff or citizens themselves, but require support from technical personnel, thus increasing cost and reducing feasibility of implementing new technology solutions.By developing an open-source platform and CareStore, based on standardised user-interface and recognition technology, where all technologies and devices can be seamlessly installed and connected, we would most likely increase the incentive to implement assisted living technologies in the homecare an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Systematic Micro- and Nanoplastics  Assessment and Risk Evaluation of Their Toxicity on the Brain'.

assistant: **Objectives**

Micro- and nanoplastics (MNPs) have recently been detected in human brain tissues, raising significant concerns about their potential role in brain health. However, there remains a critical gap in understanding how MNPs enter the brain, whether they can cross the blood-brain barrier (BBB), and the mechanisms involved in their interaction with brain tissues. Current studies have been limited by the absence of suitable BBB models and advanced analytical techniques.This project aims to address this gap by developing a novel BBB-on-a-chip model, combining advanced MNP analytical, labeling, quantification and mapping techniques, to systematically investigate these interactions. It will explore whether MNPs can penetrate the BBB, elucidate the mechanisms of translocation, and assess the biological impacts of MNPs on brain health, with a focus on long-term risks related to cognitive decline and neurodegenerative diseases. Secondments at Queen Mary University of London (QMUL) will focus on advanced MNP labeling and quantification techniques, while secondments at SynVivo (SYN) will involve developing the BBB-on-a-chip model, introducing cutting-edge 3D modeling capabilities. These secondments will provide critical expertise and resources, ultimately expanding the scope and impact of the research. The fellow will gain valuable skills in chip model development, material labeling, and toxicological risk assessment, which will enhance his future career prospects in interdisciplinary environmental health research.


**Keywords:** Microplastic, nanoplastics, toxicity, biocorona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Ultrafast quantum transport in nanosystems controlled via phase-locked single cycles of light'.

assistant: **Objectives**

The aim of the project consists in starting new experiments in which the absolute optical phase of quasi single-cycle light pulses is harnessed to directly control charge transport in quantum nanosystems. The basic concept of this technique relies on the fact that, with ultrashort pulsed laser sources, it is possible to obtain extremely high peak intensities and thus high peak electric fields. Such pulses can be focused on a nano-scale junction of an electronic circuit. The strong field then allows symmetry breaking of the electronic band structure and triggers charge tunneling from one side of the junction to the other one through the potential barrier of the dielectric medium. Since this effect depends nonlinearly on the bias field, a net current results in the limit of phase-locked excitation pulses thus giving rise to temporal resolution and control on the sub-cycle timescale. In this project we want to exploit the described phenomenon in a regime in which it would be possible to study ultrafast electron transport in nanosystems with strong quantum confinement. To this end, we plan to fabricate nanostructured plasmonic junctions in patterned circuits loaded with single quantum systems such as semiconductor quantum dots. To study the quantum charge transport on such systems we need extremely high sensitivities and a control of the current down to a single electron per pulse. In addition, it is extremely important that the pulse that triggers the quantum tunneling of the charges is far from any resonant optical excitation. For these reasons, we will develop a phase-locked Er:fiber laser source equipped with Tm: and Yb:fiber amplifying stages that will be able to generate single optical cycle optical pulses at wavelenghts around 2 microns.We envision that the study of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EXercise as a regulator of hepatic NAD metabolism and MItochondrial function  in Non-Alcoholic fatty liver disease' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in industrialized countries, including Europe, and comprises a spectrum of disorders ranging from hepatic lipid accumulation (steatosis) to inflammation (non-alcoholic steatohepatitis, NASH) and fibrosis. Pathogenic pathways leading from hepatic steatosis to NASH are still incompletely understood resulting in a lack of approved therapeutic options besides life style changes. Physical activity is effective to prevent NAFLD progression. The mechanism of exercise action on liver mitochondrial metabolism is not clear yet. However, exercise might exert its positive effects via increasing hepatic nicotinamide adenine dinucleotide (NAD) levels. Several studies showed that the hepatic NAD metabolism is dysregulated during the development of NAFLD and that exercise has a positive effect on NAD metabolism and function of NAD dependent enzymes in skeletal muscle. The functionality of mitochondrial metabolism is highly dependent on the maintenance of the organellar NAD pool. Mitochondrial dysfunction has been implicated in the progression from steatosis to NASH. We hypothesize that a dysregulated NAD metabolism in the liver is involved in the development of hepatic mitochondrial dysfunction in NAFLD/NASH. Our overall aim is to define the impact of exercise on hepatic mitochondrial dysfunction and test whether exercise effects are mediated via restoration of NAD metabolism. We will achieve this by combining the knowledge on hepatic NAD metabolism of the fellow with the expertise in exercise mouse models and on analysis of mitochondrial function of the Supervisor. This study is one of the first to comprehensively examine the interaction between exercise, mitochondrial dysfunction as a cause of NAFLD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Monitoring mentAl healTh in brEast canceR'.

assistant: **Concept**

One over three women with breast cancer will develop mental health issues, adding the burden of a deterioration of their quality of life to the management of cancer itself.The objective of the MATER project is to improve the detection and monitoring of mental health in women with breast cancer by leveraging symptom networks and vocal biomarkers. The project addresses three research questions. We first hypothesize that the use of symptom networks will allow a better understanding of the links between depressive symptoms, fatigue and a decreased quality of life, and identify the most important symptoms in the deterioration of the mental health of these women.We also assume that automatically estimating these symptoms using voice descriptors extracted from real-life recordings and machine learning pipelines will make it easier to monitor them in the patients' homes. Finally, we hypothesize that the use of a Bayesian network algorithm combining the symptom network and the voice-based symptom estimations will allow a more accurate joint estimation of these symptoms - and thus improve the identification and monitoring of mental health-related symptoms in women with breast cancer.The interdisciplinary MATER project is based on Colive Voice, a unique dataset of clinical and voice data and leverages both the complementary host's and supervisor's extensive experience in digital and personalized health and the applicant's knowledge of vocal biomarker design and machine learning, mental disorder semiology, and Bayesian networks. This project will allow the applicant to improve his skills in voice signal processing, precision health (in particular in oncology), but also in scientific project management and in research valorization, creating an international network and elevating his
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Decoding consequences of complex chromosomal aberrations by multi-modal single-cell deconstruction to overcome treatment-resistance cancer' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

How does a cell with unstable, complex genomic rearrangements stay alive, and even give rise to aggressive, highly resistant malignancies? This question remains an ultimate research challenge for cancers with highly aberrant genomes, such as acute myeloid leukemia with complex karyotype (CK-AML). Its etiology, time-resolved clonal dynamics, molecular heterogeneity, and treatment resistance mechanisms are still largely elusive. In particular, the genetic and non-genetic dynamics that drive cancer progression under treatment are elusive to current technologies and escape single-cell resolution. SHATTER-AML will tackle the genomic enigma of CK-AML by analyzing longitudinally obtained triplicate (diagnosis, treated, relapse) samples to examine intra-patient genetic and non-genetic heterogeneity using scNOVA-CITE, a newly developed multi-modal single-cell omics approach. This approach combines (i) structural variation discovery with nucleosome occupancy and cis-regulatory element accessibility profiling (scNOVA) with (ii) cellular indexing of transcriptomes and epitome sequencing (CITE-seq). We will uncover multi-level disease dynamics at single-cell and subclonal levels along the disease course, providing a blueprint for studies of other structurally instable cancers. Identified molecular insights into the networks mediating therapy resistance, leukemic stem cell activity and immune escape will be further explored functionally in patient-derived in vivo models. Pharmacological interference and CRISPRi are used to engineer deregulated signaling pathways for precision oncology, and CRISPRa screens are applied to sensitize CK-AML stem cells to natural killer cell-mediated elimination.   SHATTER-AML will fundamentally transform our understanding of the impact of clonal evolutio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CRitical Incident management training System using an Interactive Simulation environment' to be submitted under Seventh Framework.

assistant: **Abstract**

CRISIS is a 42 month project to research and develop an advanced critical incident management, interactive simulation environment for training security and emergency personnel in airport operational security. The prototype to be delivered will be distributed, scalable, collaborative interactive simulation environment that will enable training of crisis managers and their staff at airports, at different levels of the organization. The prototype system will avoid the simulation paradigm where the trainee selects one of a number of pre-set drill oriented choices at a predictable decision point. Instead, using an interactive games paradigm, the trainees will be able to practice situation and cue assessment, problem diagnosis, decision making and action coordination, in real-time in response to a critical incident. Currently, one key problem hindering the maintenance of a high level of preparedness in operational security organizations at airports is the long 2-year wait between major exercises. In CRISIS, we will enable organizations and individuals to train-on-demand, and as frequently as needed due to the innovations, such as end-user re-configurability of training scenarios. This will allow staff to train individually 'playing' against the system, as a team within an organization, across organizations, and at different levels of the command hierarchy. CRISIS will adopt a 3-stage development strategy, integrating, testing and iteratively evaluating user performance at each step of the way. The CRISIS consortium brings together a powerful combination of expertise in User modeling and requirements engineering, Games and simulation, Software engineering, distributed systems, and security, Decision sciences and technology, User performance evaluation, to deliver capability fo