RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'TransCure - International Fellowship Program on Translational Research'.

assistant: **Objectives**

The herein proposed International Fellowship Program will be integrated into the recently funded Swiss translational research program, the National Center of Competence in Research (NCCR) TransCure, a joint research effort of 28 academic research groups located in major Swiss universities. The aim of the NCCR TransCure is to improve prevention and treatment of chronic diseases such as cancer, osteoporosis, neurodegenerative diseases, heart diseases, etc. Recent progresses in biomedical research have revealed that the dysfunction of specific membrane proteins contributes to the pathogenesis of these diseases. NCCR TransCure aims at studying the function of implicated membrane proteins and developing innovative drugs that control them in the diseased state.Membrane transport proteins and ion channels are particularly important pharmaceutical targets as they are the gatekeepers of the membranes of cells and cell organelles. In particular, they control the uptake and efflux of vital substances such as sugars, vitamins, trace elements, signal molecules and drugs. Targeting these proteins has been rather neglected yet by the pharmaceutical industry due to their structural complexity and hydrophobic nature. Thus, these proteins represent a large and unexplored pharmaceutical wealth. The TransCure premise is that integration of medicine, structural biology and chemistry will be tremendously beneficial in accelerating the translational avenue from ""gene to drug"".The future success of translational research in Europe depends on well-trained and multidisciplinary-oriented young researchers. The Swiss interdisciplinary TransCure research network represents the ideal platform for the training of such researchers from Europe and all over the world. Therefore, an integration of this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Personalised Adaptive Medicine'.

assistant: **Objectives**

Personalised drug formulation is a hot topic but state of the art approaches are limited by low scalability, cost, and regulatory hurdles, while current polypill formulation efforts are hindered by liquid form or hot melt addition approaches, posing stability issues. These bottlenecks carry a great societal price, as the synergic boost of drug combinations was recently demonstrated to reach significant improvement in treatment outcomes, while keeping active substances in the ideal physiological concentration window is known to maximise efficiency and reduce side effects. Also, polypharmacy is a real problem leading to dosing errors and significant loss in patient adherence. Finally, while Big Data Health IT system concepts on the far horizon hold potential to gather the large amount of reliable dosage-patient data required for evidence-based personalised medicine, the technology to deliver such data – well-tracked patient/dosing procedures with bi-directional digital information flow – is missing.  The PERAMEDIC project proposes to resolve these problems with a breakthrough solution: a stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised, segmented release polypills, with an inherently digital technology interface. The system relies on integrating several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel powder dosing of drugs into sealed microcompartments. The envisaged device would be a desktop-size pill/capsule printing machine, using canisters of powdered drugs and bioresorbable polymer matrix material. Application scenarios would be first clinical settings, then at later stage, pharmacy locations and medical practi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hybrid electronic-photonic architectures for brain-inspired computing' (HYBRAIN).

assistant: **Concept**

As artificial intelligence (AI) proliferates, hardware systems that can perform inference at ultralow latency, high precision and low power are crucial and urgently required to deal – especially quasi-locally, i.e. ‘in the edge’ – with massive and heterogenous data, respond in real time and avoid unintended consequences and function in complex and often unpredictable environments. Conventional digital electronics and the associated computer architecture is unable to meet these stringent requirements with sub-ms latency inference and a sub-10W power budget, using convolution neural networks (CNNs) on benchmarks such as ImageNet classification. HYBRAIN’s vision is to realize a pathway for a radical new technology with ultrafast (~1 microsecond) and energy-efficient (~1 watt) edge AI inference based on a world-first, brain-inspired hybrid architecture of integrated photonics and unconventional electronics. The deeply entwined memory and processing like in the mammalian brain obviates the need to shuttle around synaptic weights. The most stringent latency bottleneck in CNNs is in the initial convolution layers. Our approach will take advantage of the ultrahigh throughput and low latency of photonic convolutional processors (PCPs) employing novel phase-change materials in these initial layers to radically speed up processing. Their output is processed using cascaded electronic linear and nonlinear classifier layers, based on memristive (phase-change memory) crossbar arrays and dopant network processing units, respectively. HYBRAIN’s science-towards-technology breakthrough brings together the world’s top research groups from academia and industry in complementary technology platforms. Each of these platforms is already highly promising, but by integrating them, HYBRAIN will h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Four experiments in Topological Superconductivity.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Topological materials have developed rapidly in recent years, with my previous ERC-AG project 3-TOP playing a major role in this development. While so far no bulk topological superconductor has been unambiguously demonstrated, their properties can be studied in a very flexible manner by inducing superconductivity through the proximity effect into the surface or edge states of a topological insulator. In 4-TOPS we will explore the possibilities of this approach in full, and conduct a thorough study of induced superconductivity in both two and three dimensional HgTe based topological insulators. The 4 avenues we will follow are:-SQUID based devices to investigate full phase dependent spectroscopy of the gapless Andreev bound state by studying their Josephson radiation and current-phase relationships.-Experiments aimed at providing unambiguous proof of localized Majorana states in TI junctions by studying tunnelling transport into such states.  -Attempts to induce superconductivity in Quantum Hall states with the aim of creating a chiral topological superconductor. These chiral superconductors host Majorana fermions at their edges, which, at least in the case of a single QH edge mode, follow non-Abelian statistics and are therefore promising for explorations in topological quantum computing.-Studies of induced superconductivity in Weyl semimetals, a completely unexplored state of matter.Taken together, these four sets of experiments will greatly enhance our understanding of topological superconductivity, which is not only a subject of great academic interest as it constitutes the study of new phases of matter, but also has potential application in the field of quantum information processing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A Consolidated Library of Anglo-Saxon Poetry'.

assistant: **Innovation**

As elsewhere in Europe, Anglo-Saxon England saw a development from an oral, vernacular, native, and pagan culture to one that was primarily literate, Latinate, imported, and Christian; and such a transition is clearest in Anglo-Saxon verse. CLASP will focus on all surviving verse of Anglo-Saxon England, composed in Old English and Anglo-Latin over a period of over four centuries (c. 670–1100 CE), and produce for the first time an online and interactive consolidated library, marked up through TEI P5 XML to facilitate the identification of idiosyncratic features of sound, metre, spellings, diction, syntax, formulas, themes, and genres across the entire corpus, so forging connections and suggesting more certain chains of influence both within and between the two main literary languages of Anglo-Saxon England. The bilingual corpus comprises almost 60,000 lines of poetry, with about half surviving in each language, and mostly appearing in only a single witness, usually in manuscript. More than fifty named poets are identified, many of them dateable with more or less precision, whose influence on each other can be closely documented, while in the case of anonymous verse, most of which is in Old English, the focus will be on tracing potential influence between texts, to establish a comparative rather than an absolute chronology. CLASP will use the full panoply of digital resources, including sound- and image-files where relevant, to make the oldest surviving poetry in England available to a modern audience for unprecedented kinds of exploration, comprehensive analysis, and interrogation, and in a series of conferences, workshops, and other publications will show the potential of such a comprehensive multilingual corpus to revolutionize perspectives not only on Anglo-Saxon Engl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'NEXT-GENERATION BUILDING INFORMATION MODELING TO SUPPORT EVALUATION OF HUMAN BEHAVIOR IN BUILT ENVIRONMENTS', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposal argues that current building modeling tools, including popular BIM (Building Information Modeling) systems, provide a poor, inadequate representation of buildings: they represent only the physical and material characteristics of buildings. Buildings, unlike other products, cannot be understood independently of their context, of their intended use, and of their intended users.This shortcoming hinders the ability of current building models to support evaluations other than those based on physical and material characteristics of the building, such as lighting, energy consumption, and structural stability. In particular, the impact of a building that has not yet been built on the life and activities of its future users—a key element in determining whether or not the proposed building will meet the needs of its intended users—is not afforded by current building models. To afford comprehensive prediction and evaluation of future buildings, we also need to model the purpose and function of the building, and the social, cultural, and economic profile of the people who will use it.Although predicting users' behavior in a built environment and their interaction with the building and with other people is a highly complex task, vast research exists that is devoted to analyzing and explaining human behavior in built environments. Still, due to the shortcomings of building models, this knowledge rarely make into the practice of architectural design, at the time buildings are being designed.The proposed research aims at remedying that shortcoming by developing a more a comprehensive building modeling method, which will include form, function, and use information. A better model will lead to better designed buildings. In an era when the irrevocable impact of the built env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A RAPID NON-INVASIVE INSTRUMENT FOR DETERMINING THE GLOBAL AND LOCAL POROSITY OF PARTS MANUFACTURED BY POWDER METALLURGY' (SINTEST) targeting Seventh Framework.

assistant: **Abstract**

Powder Metallurgy (P/M) is a major manufacturing route for many industries. While the demand for P/M parts in its traditional automotive market is predicted to grow, future sector expansion depends directly upon its capability to manufacture zero-defect, complex mechanical P/M parts for industries such as aerospace and medicine. To comply with such standards, parts manufacturing must be optimized. However, consortium SMEs lack time-efficient and systematic instruments and procedures for the inspection of the inner structure of parts, as well as expert guidance to solve the complex problem of P/M, zero-defect optimization, constituting this a significant threat to their cost-effectiveness and competitiveness within the industry.  The lack of an adequate inspection system has important implications from the point of view of quality assurance, since it increases the design costs and the time of a tool set for a new product, which is made with a trial-and-error procedure and which generates surplus costs. Consortium SMEs have identified a clear need for a non-invasive instrument for determining the porosity of P/M parts. The proposed SINTEST technology will increase consortium SME Powder Metallurgy competitive advantage by offering a highly effective and cost-efficient in-situ system that can detect deficiencies in sintered parts. Through the project, a new efficient and cost-effective inspection tool will be developed based on ultrasonic technology, which makes it possible to provide a global density map of sintered parts. The commercial objective of this SINTEST proposal is the development of a technology to better control the P/M output into the market, increasing manufacturer reliability for the supply of complex parts and EU competitiveness, as well as opening up a hos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Study of Endothelial and Osteoclastic cells cooperation for Bone Tissue Engineering applications' (EOBOTE) targeting Seventh Framework.

assistant: **Abstract**

Bone diseases like osteoporosis and osteoarthritis are affecting an increasing number of people worldwide. The short- and long-term consequences are an increasing risk of fractures, total joint replacement and bone grafting. Current treatments of osteoporosis are based on inhibition of bone resorption and at best preserve bone volume but do not improve bone formation together with a high risk of complications like an osteonecrosis of the jaw. Furthermore, in clinical cases of bone loss or during osteoarticular prostheses surgeries, bone autograft remains the ‘gold standard’ for surgeon as bone substitutes or bone filler, respectively. In fact, despite the good clinical results of calcium phosphate materials in the same applications and their advantages over bone autograft, their lack of biological properties is still a major drawback. These examples clearly demonstrate the actual limits of the current clinical solutions in the field of treatment of bone disorders and bone tissue regeneration. A key factor for bone repair is the creation of the vascular network allowing optimal cell colonization and mineralized tissue formation. Recent studies have shown the crucial role of cells responsible of bone resorption (osteoclastic cells) in the initiation bone remodeling but also in the recruitment of blood vessel forming cell (endothelial cells). Taking together, this data can explain major issues caused by bisphosphonates as well as the limited application of synthetic materials for the treatment of bone defect. Thus a better knowledge of the communication between cells would highlight the mechanisms of the vascularisation process. This project aims to characterize the specific interactions between osteoclastic and endothelial cells in order to provide a new route both for th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'EFFICIENCY IN USE OF RESOURCES: OPTIMIZATION IN POTATO PRODUCTION'.

assistant: **Objectives**

The purpose of this Concerted Action is to provide a link between national programmes, pooling data, and harmonizing practices. With the large amount of effort that is being devoted to the problem of nitrogen nutrition in the potato crop, the outstanding requirement is the development 0 a forum or network that will enable researchers throughout Europe, and in co-operating countries, to collaborate, to exchange ideas, to develop common protocols. A principal focus of the Action will b collectively to develop methodologies to be used, as appropriate, by producers, laboratories and policy makers and, ultimately, to develop a definition of how decisions should be made by growers and managers to optimize the nitrogen nutrition of their crops. The objectives are to:- Develop means for farmers to grow potato crops in which the supply and demand for N are in balance, so as to limit losses of N to the environment, and yet to maintain yield levels. Provide a rational assessment of the value of animal.manures; thereby to optimize a resource, minimize a pollution problem, and minimize on the energy and other costs of mineral N. And, as a necessary corollary to develop means for farmers to optimize demands on water resources by using only sufficient water to capitalise on available N while avoiding both stress and leaching, or by alternative procedures including methods of controlled drainage. These each lead to subsidiary but contributory objectives detailed in Section 2 'Work Content'.And, finally, as a necessity to give value to the outcome of the Action it will address dissemination of its work in four ways: (i) Publish a handbook of methods to assist practitioners in the field in the methods and procedures to use, written and produced with the practitioner in mind. (ii) Outline
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A new method for theoretical spectroscopy of strongly correlated materials - dynamical configuration interaction' (DCI), addressing dissemination and exploitation.

assistant: **Impact**

As researchers continue to search for new technological materials, they are increasingly exploring the regime of strongly correlated molecules and solids.  Strongly correlated materials are those with strongly interacting electrons that cannot be accurately described by simple mean-field methods in physics.  Theoretical spectroscopy for strongly correlated materials gives the ability to predict their excited states important for applications - their spectra - by numerical calculations instead of synthesizing and measuring them in the laboratory.  However, accurate theoretical spectroscopy for strongly correlated systems is a considerable theoretical challenge.  We present a new quantum embedding theory for strong correlation that embeds quantum chemistry inside of many-body perturbation theory (MBPT).  In our theory, strongly correlated electrons are treated with configuration interaction (CI) using the exact ab-initio Hamiltonian.  Weakly correlated states are treated with less expensive approximations in many-body perturbation theory (GW/BSE).  The coupling between the two spaces gives a dynamical correction to the normal CI Hamiltonian, a method that we call dynamical configuration interaction (DCI).  The method naturally includes non-local correlation, is systematically improvable by expanding the CI basis, and eliminates the need for frequency dependent quantities common in Green's function embedding.  Our goal is to develop an efficient, scalable implementation of DCI and benchmark it against other methods in many-body physics and quantum chemistry.  Eventually, we will apply our DCI implementation to porphyrin and phthalocyanine molecules.  These molecules host strongly correlated d-electrons at their center and are heavily researched for their potential technolo