RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Doping, Charge Transfer and Energy Flow in Hybrid Nanoparticle Systems'.

assistant: **Objectives**

We target a frontier in nanocrystal science of combining disparate materials into a single hybrid nanosystem. This offers an intriguing route to engineer nanomaterials with multiple functionalities in ways that are not accessible in bulk materials or in molecules. Such control of novel material combinations on a single nanoparticle or in a super-structure of assembled nanoparticles, presents alongside with the synthesis challenges, fundamental questions concerning the physical attributes of nanoscale systems. My goals are to create new highly controlled hybrid nanoparticle systems, focusing on combinations of semiconductors and metals, and to decipher the fundamental principles governing doping in nanoparticles and charge and energy transfer processes among components of the hybrid systems. The research addresses several key challenges: First, in synthesis, combining disparate material components into one hybrid nanoparticle system. Second, in self assembly, organizing a combination of semiconductor (SC) and metal nanoparticle building blocks into hybrid systems with controlled architecture. Third in fundamental physico-chemical questions pertaining to the unique attributes of the hybrid systems, constituting a key component of the research. A first aspect concerns doping of SC nanoparticles with metal atoms. A second aspect concerns light-induced charge transfer between the SC part and metal parts of the hybrid constructs. A third related aspect concerns energy transfer processes between the SC and metal components and the interplay between near-field enhancement and fluorescence quenching effects. Due to the new properties, significant impact on nanocrystal applications in solar energy harvesting, biological tagging, sensing, optics and electropotics is expected.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Grey Area Mitigation for Hybrid RANS-LES Methods' (GO4HYBRID).

assistant: **Innovation**

The aeronautical industry lacks confidence in the accuracy of computational fluid dynamics (CFD) in areas of highly non-linear, unsteady flows close to the flight envelope borders, which demands advanced approaches and methods. The family of Hybrid RANS-LES Methods (HRLM) is the best candidate for the next generation of CFD methods for increased fidelity at industrially-feasible expense. While HRLM have been proven to perform considerably better than conventional (U)RANS approaches in situations with strong or massive flow separation, they are hampered by the Grey Area issue once they have to deal with thin separation regions and where shear layer instabilities are weaker.As exactly these areas are of high importance for aircraft performance (lift, loads) the acceptance of HRLM strongly depends on the ability to mitigate the extent of the Grey Area (GA). With the new/advanced Grey Area mitigation approaches, the Go4Hybrid project offers hybrid RANS-LES methods that improve predictive capability with increased flexibility and reduced user decision load. Hence, the incentive for future use of these highly sophisticated methods goes in line with a considerably high impact:• Progress beyond the state-of-the-art for non-zonal methods is achieved by the development and demonstration of generally-applicable extensions to mitigate the Grey Area problem, thereby extending their applicability to important industrial flows at the performance frontiers.• For embedded methods, a focus will be placed on improving methods so that they are applicable to arbitrary complex geometries, as opposed to many existing techniques that require e.g. canonical boundary layer assumptions or homogeneous flow directions and are hence fundamentally less flexible.In general, development work will pursu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ENGINEERING CELLULAR SELF‐ORGANISATION BY  CONTROLLING THE IMMUNO-MECHANICAL INTERPLAY' in the context of a Horizon Europe call.

assistant: **Objectives**

Both scar formation and restitutio ad integrum during bone regeneration rely on cellular self-organisation that involve cell contraction and fibronectin/collagen formation. This early stage of cellular self-organization is later followed by angiogenesis and mineralisation. Scar-free regeneration of physiological tissue homeostasis requires balanced downregulation of early inflammation, however little is understood of the immune-mechanical coupling involved. We aim to lay the foundation for reducing patient suffering resulting from scarring by combining two distinct scientific worlds, for which we have been a major driving force: the distinct regulation of local inflammation and the mechano-biology during regeneration. By combining both of our areas of expertise, we aim to harvest the potential of the novel cross-disciplinary field Immuno-Mechanics.This ambitious project concentrates first on identifing the different mechanical niches that immune cells experience early in successful healing and non-healing. Second, we will engineer synthetic niches to control fibroblasts and fibroblast-immune cell interactions to steer cell self-organisation and matrix formation in vitro. Third, we plan to verify that these synthetic niches reprogram hematoma composition and can thus reduce later scarring in vivo. The proposed experiments are challenging as they have never been done this way before, but are feasible since they capitalise on our strengths in osteo-immunology and mechano-biology. Novel technologies will be combined in a unique way to engineer the immune-mechanical cell niche, to passivate activated immune cells and to reprogramme cell fate. This will allow us to substantially advance the basic understanding of the interplay between immune cells and their mechanical niche d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Climatic impacts of volcaninc ash electrification' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Volcanic eruptions affect the Earth’s climate by altering radiation balance through the injection of aerosols in the stratosphere. Conventional knowledge assumes that volcanic influences on climate are mediated by sulfate aerosols only. Recent space-based measurements, however, have challenged this assumption by providing definite evidence that the stratospheric aerosol layer is actually a mixture of sulfates and ash for many months after the eruption. This project aims to understand the unknown processes responsible for the prolonged residence time of the volcanic ash in the stratosphere and to assess its climatic impact. Our main hypothesis is that electric charges of the volcanic plume are responsible for keeping volcanic ash aloft. Charge separation in the volcanic plume induces a local electric field and a force that counteracts the ash particle weight, thus reducing its settling velocity and prolonging its lifetime. ElectricVolcano will combine state-of-art remote sensing techniques, detailed aerosol charging theories and comprehensive atmospheric modelling to provide for the first time a thorough assessment of the impact of electrification on the life cycle of volcanic ash in the stratosphere. Through cutting edge inter-interdisciplinary research, the project produces a step change in the way volcanic eruptions are treated by modelling centers and inter-comparison studies, with the potential to significantly reduce uncertainties in natural forcing and near-term predictions. Carefully-designed research and training activities, combined with the world-class excellence on aerosol-electrification research of the Host Institute, guarantee the success of the proposed project. ElectricVolcano provides new knowledge, tools and resources to the Experienced Researcher for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Monomer sequence control in Polymers : Toward next-generation precision materials' (EURO-SEQUENCES).

assistant: **Innovation**

The aim of the project “Euro-Sequences” is to establish a multidisciplinary training network on the emerging topic of sequence-controlled polymers. It has been shown during the last 5 years that such polymers open up unprecedented options for the future of manmade materials. Indeed, similarly to biopolymers such as DNA and proteins, synthetic sequence-controlled polymers contain precisely engineered chain-microstructures that allow a fine control over their molecular, nanoscopic and macroscopic properties. For instance, these new types of polymers are relevant for applications in molecular data storage, catalysis, and nanomedicine. However, this field of research is young and therefore, fundamental and applied research is still mandatory. Thus, it seems timely and appropriate to federate top-European researchers working on that topic. The proposed network is composed of 7 academic partners and 2 companies and connects researchers with complementary expertise in areas such as organic chemistry, polymer synthesis, supramolecular chemistry, physico-chemistry and materials science. This multidisciplinary network will focus on different scientific aspects. A first important objective will be the development of facile and rapid chemical methods for ‘writing’ molecular information on polymers. In addition, analytical techniques that allow characterization and sequencing of polymers will be studied. The folding and self-assembly of sequence-controlled polymers will be also examined in order to understand the correlation between controlled primary structure and higher levels of organization. Eventually, a crucial aim of this project will be the conception of new types of plastics materials. This network will be a unique scientific environment for training PhDs. The students will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cellular Destruction Mechanisms that Create New Lives' (SPERMDESTRUCT).

assistant: **Innovation**

Apoptosis, the major form of programmed cell death (PCD), is executed by caspases. However, activation of caspases can also promote a variety of vital cellular processes. Furthermore, cell death can sometimes proceed in the absence of apoptotic caspases by triggering alternative cell death (ACD) pathways. The main goal of my proposal is to delineate the molecular mechanisms, pathways and components underlying three distinct, evolutionarily conserved, cellular destruction processes, all associated with the Drosophila sperm life cycle, and to screen blood DNA samples from fertility clinics for mutations in human homologous genes. The first process, termed germ cell death (GCD), eliminates about 25% of the pre-meiotic germ cells through an ACD pathway. In the second process, the bulk cytoplasmic contents of the terminally differentiating spermatids are removed in a process called ‘individualization’, which involves active caspases. The third process occurs immediately after fertilization to selectively eliminate the sperm mitochondrial derivative. Similar cellular processes are also instrumental for the development and homeostasis of a variety of tissues and organs in essentially all multicellular organisms. Therefore, not only will this study enhance our understanding of male germ cell maturation and function, this unique system also provides an opportunity to study these important cellular processes using physiological conditions. The extraordinary degree of anatomical and molecular conservation of spermatogenesis in animals with flagellated sperm also signifies the extension of these studies to human patients. Although human infertility is a major health problem affecting 7% of men world-wide, we are still rather ignorant about the genetic causes of male infertility. My
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthesis of PROTAC-Antibody Conjugate for Application in Acute Myeloid Leukemia Therapy' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The field of immunotherapy has become one of the most promising strategies in fighting cancer. By using the incredible features our very own immune system already possesses, like the powerful tool of specific antibody-antigen recognition, a new generation of drugs can be generated.  The idea of linking cytotoxic drugs to monoclonal antibodies with high affinities to specific tumor cells will tremendously improve drug delivery, as tumor-associated antigens can be found by antibodies and the high cytotoxicity of the conjugated drug is used to achieve efficient cancer treatment with less side effects. In this research proposal, we establish a new therapeutic platform that uniquely combines the advantages of two rapidly developing areas – immunotherapy and targeted protein degradation – by developing first class of PROTAC-Antibody Conjugates (PAC). The resulting novel therapeutic agents will help to overcome the limitations arising from lack of cell specificity of PROTACs by exploiting tissue-specificity of the antibody component. Several studies reported encouraging data for the treatment of acute myeloid leukemia (AML) with antibody drug conjugates (ADC) that target the myeloid antigen CD33. In addition, a functionalisable BET inhibitor will be employed in protein degrader construct, generating a new class of small-molecule BET protein degraders. Besides, the proposed self-immolative linker chemistry will allow the traceless realease of the PROTAC once the PAC is internalized into the target cell. Moreover, we will use novel site-selective cysteine bioconjugation approach to build homogenous conjugates that, unlike current examples built using maleimide chemistry, are fully stable in the blood. Overall, this approach will be applicable to any protein of interest and there
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Configuration in Industrial Product Families' to be submitted under Fifth Framework.

assistant: **Abstract**

The project will define and validate a product derivation methodology that is practicable in industrial application. The consortium, which consists of two industrial partners and academic partners specialising in software architecture and artificial intelligence, intends to use both the product line approach and structure-oriented configuration technologies. The methodology will be developed top-down, starting from requirements defined through case studies of the industrial partners and will be validated through application.The project lasts 36 months and is divided into the following phases: investigation (6 months), definition (9 months), trial (15months) and assessment (6 months). The configuration approach used by the methodology optimises reuse strategies in application engineering, which alleviates a deficit in other product line approaches. The consortium intends to document the methodology in a book published at the end of the project.Objectives:The project has the following sub-objectives: to use separate benefit feature and artefact models and to develop intermediate knowledge representations to connect them; to validate the methodology with industrial-scale applications; to define a configuration notation that has the expressiveness to handle the variability endemic in industrial product lines and to define strategies to maximise the reuse of available generic software components.Work description:The work is divided into two main streams: methodological and experimental, primarily being carried out by the academic and industrial partners, respectively. Both streams follow the same phases in approximately the same time frame.In the investigation phase, the factors driving the configuration process of the industrial partners will be determined and documented in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Pervasive Upstream Non-Coding Transcription Underpinning Adaptation'.

assistant: **Objectives**

Genomic DNA represents the blueprint of life: it instructs solutions to challenges during life cycles of organisms. Curiously DNA in higher organisms is mostly non-protein coding (e.g. 97% in human). The popular “junk-DNA” hypothesis postulates that this non-coding DNA is non-functional. However, high-throughput transcriptomics indicates that this may be an over-simplification as most non-coding DNA is transcribed. This pervasive transcription yields two molecular events that may be functional: 1.) resulting long non-coding RNA (lncRNA) molecules, and 2.) the act of pervasive transcription itself. Whereas lncRNA sequences and functions differ on a case-by-case basis, RNA polymerase II (Pol II) transcribes most lncRNA. Pol II activity leaves molecular marks that specify transcription stages. The profiles of stage-specific activities instruct separation and fidelity of transcription units (genomic punctuation). Pervasive transcription affects genomic punctuation: upstream lncRNA transcription over gene promoters can repress downstream gene expression, also referred to as tandem Transcriptional Interference (tTI). Even though tTI was first reported decades ago a systematic characterization of tTI is lacking. Guided by my expertise in lncRNA transcription I recently identified the genetic material to dissect tTI in plants as an independent group leader. My planned research promises to reveal the genetic architecture and the molecular hallmarks defining tTI in higher organisms. Environmental lncRNA transcription variability may trigger tTI to promote organismal responses to changing conditions. We will address the roles of tTI in plant cold response to test this hypothesis. I anticipate our findings to inform on the fraction of pervasive transcription engaging in tTI. My pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Safety improved with a new concept by better awareness on airport approach domain' under Sixth Framework.

assistant: **Concept**

SINBAD aims to perform the proof of application of a new concept, intended to improve aircraft safety and security at airport approach to 2010 horizon. Collision avoidance is currently ensured jointly by the Air Traffic Management System (ATMS),and the Airborne Collision Avoidance System. Both systems actually are ineffective against the risk of accidental or hostile collision by non cooperative small or low flying aircraft.The main targets of SINBAD to overcome these limitations are: -to improve drastically the capability of the ATMS to monitor such non cooperative aircraft, using a breakthrough low cost sensor technology, the Primary Multilateration System (PMS), -to support controllers by providing them with an Active Hazard Assessment (AHA) capability, allowing them in case of confirmed danger to quickly alert the adequate authorities and if needed to the relevant airliners.