RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Functional and biochemical characterisation of novel ABC transporters of biomedical interest in the protozoan parasite Leishmania' to be submitted under Sixth Framework.

assistant: **Abstract**

Leishmaniasis has become the second most important human parasitic disease, affecting more than 12 million people worldwide. Its visceral form is always mortal in the absence of treatment. The disease is spreading since 1993, mainly due to the appearance o f resistance to the current drugs Glucantime and Pestontam. Thus, in some tropical hiperendemic areas, most cases are non-responsive to the treatment, whereas in Spain and other Mediterranean countries, drug-resistance leishmaniasis keeps on spreading as t he number of patients co-infected with HTV increases. Therefore, there is an urgent need for developing new drugs. Miltefosine is the most promising alternative, and it has become the first oral drug registered to treat visceral leishmaniasis.As in the ca se of cancer cells resistant to the chemotherapy, ABC (ATP Binding Cassette) transporters over-expression is responsible of the appearance of parasites resistant to many of these drugs, including Glucantime, Pestontam and miltefosine. Only three classes of ABC transporters have been studied in Leishmania, but the number of members of this family increases continuously as the parasite genome project is being developed. The objective of this project is to study the functional role of some of these new ABC genes. We plan to analyse their implication in key biological functions of the parasite to check their potential as new drug targets for leishmanicidal agents. Moreover, we will determine the ability of these transporters to confer resistance to miltefosine and other drugs. With this aim, we will generate mutant parasites over-expressing or deleting these genes, and analyse the resulting phenotype.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BALkan CARD' to be submitted under Fifth Framework.

assistant: **Abstract**

The project will establish a large-scale pilot in order to perform cross border transactions over the Internet with a stored value smart card. The project will cover both EU and non EU countries and will contribute to the adoption of secure payment mechanisms in order to B2C commercial transactions over the Internet.Objectives:Balcard smart cards for cross border transactions over open networks with the use of stored value aim to satisfy the vision for global networked economy where consumers, workers and enterprises can seamlessly and dynamically come together and interact through an ubiquitous infrastructure that promotes both trust and confidence. Balcard will build and increase trust and confidence in performing payment over the Internet for goods and services. Also it will allow the growing number of Internet users to make micro-payments in an efficient and cheaper way. Balcard will administrate the obstacles delaying the massive take off e-commerce. Balcard will encounter privacy problem due to the fact that pre-paid card will require no input of personal information. It will also provide an authentic value that is transferable and acceptable by both consumer and supplier. The security of the transaction for the supplier is also covered due to the fact that he/she is instantly paid.Work description:The work plan is structured as follows: Planning, Implementation and Assessment of the pilot.Valuable results will drawn from the pilot concerning:- Security issues and ways they can overcome;- Cross border transaction issues: the solution for payment and the possible barriers for hard or soft goods sales;- Clearing and settlement issues.The banks involved will assess the possibility of rolling out the payment instrument. The project will take care of the existing oe em
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ERA-NET Cofund on Sustainable Crop Production' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The aim of the “ERA-NET Cofund on Sustainable Crop production“ (SusCrop) is to strengthen the European Research Area (ERA) in the field of crop research, in particular in relation to crop production. The SusCrop partners, a consortium of European programme managers and programme owners, will provide a joint call for proposals in the R&D area of sustainable crop production. It will be co-funded by the partners of the consortium and the European Commission and will address the following research topics: • Enhancement of predictive breeding technologies and development of new genotypes leading to new phenotypes  and crop varieties • Development and exploitation of novel integrated pest and crop management methods and practices • Improvement of resource-use efficiency of crops and cropping systems• Systemic research on agricultural crops as part of an ecosystem  (“plant as a meta-organism”)The potential of further joint funding activities of the consortium without cofunding of the EC will be proved and implemented as appropriate. By a broad range of accompanying measures that go beyond these funding activities, it will further contribute to: • Harmonise data collection on sustainable cropping to deliver a database that can be mined to build models and indices of sustainability and resilience• Develop methods of assessing the sustainability and resilience of cropping systems at different levels (e.g. field, farm, landscape) using ICT-based knowledge technologiesAdditionally it will provide a strategic direction for a sustainable crop production for the future and will work in close collaboration with the Joint Programming Initiative on Agriculture, Food Security and Climate Change (FACCE-JPI).


**Keywords:** breeding, integrated pest management, cropping, crops, genotype, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BESAFE Biodiversity and Ecosystem Services: Arguments for our future Environment' in the context of a Seventh Framework call.

assistant: **Objectives**

In order to protect biodiversity, policy makers increasingly require demonstration of its value. BESAFE will usecase studies to investigate how much importance people attribute to alternative arguments for the protectionof biodiversity and in particular how this relates to ecosystem services. It will focus on the arguments used at different governance levels and in different ecological, socio-economic, spatial and temporalcontexts. BESAFE will examine the interactions of environmental protection policies between governance scales.This will lead to an assessment of the transferability of arguments across scales. The Project will consider thecontribution that valuing ecosystem services can make in demonstrating the value of biodiversity. The resultswill be used to produce a framework that will give guidance on the effectiveness of alternative arguments andprotection strategies in various contexts. The framework will be made accessible through a web-based publicaccess database with associated toolkit. To ensure practical usability, the toolkit and database interface will bedeveloped in cooperation with stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Heritage Ecologies: culture, resilience and development in Island States' (ECO-HERITAGES) under Horizon Europe.

assistant: **Objectives**

This proposal investigates the role of cultural heritages in promoting local economic development and social and environmental resiliences, in the context of Small Island States (SIS), Small Island and Developing States (SIDS) and Sub- National Island Jurisdictions (SNIJs) located in Europe, the African continent and in the Indian Ocean. Small islands are extremely vulnerable to climate change due to their small size and exposure to sea level rise, affecting their social and economic development. Crossing anthropology, heritage, environment, development and island studies, this research aims at integrating institutional heritagization processes and indigenous knowledge systems in actions for sustainable futures. This project will be hosted by the Islands and Small States Institute (ISSI) of the University of Malta, one of the few European entities in island studies and insular development, and supervised by Dr Stefano Moncada, specialist in development economics, climate change and sustainable development, and by Professors Lino Briguglio and Godfrey Baldacchino, world leading scholars in small states and islands studies. Addressing the challenges, at European and global level, of informing effective responses to mitigate social, economic and ecological consequences of climate change, this project will focus on the SIS of Malta, the SIDS of Comoros, Mauritius and Seychelles and the SNIJs of the French island territories of Reunion and Mayotte. Through an innovative interdisciplinary methodology, this research contributes with ethnography and cultural studies to sustainable development theories and brings socio-economic resilience analyses to heritage studies. This research will contribute, overall, to the role of Malta and of SIS in the UN actions for Sustainable Develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Motion planning and control for general car-trailer systems'.

assistant: **Concept**

Research objectives and content In this research project we intend to face the problem of planning feasible paths for the general two-trailer system. It consists of a car pulling two trailers, each hooked at a distance d>0 from the preceding wheel axle. This system can be thought of as composed by two virtual sub-systems: the first one consists of the car and first trailer, while the second one is made of the first and the second trailer. When considered separately, each of these two subsystems is flat. Roughly speaking, a system is flat if we can find a set of outputs (equal in number to the number of inputs) such that all states and inputs can be determined from these outputs without integration. Flat outputs and their derivatives completely describe the trajectories of the relative flat system. For the considered subsystems, this means that their states evolution are characterised by the planar curve described by the flat output, its tangent and its curvature. The key idea that we want to explore is based on the possible decomposition of a non-flat system into flat components. It consist in finding a parameterised family of curves that solve the planning problem for each of the two subsystems and satisfy a constraint imposed by the relation between these two (fictitious) subsystems. Since the real system is controllable, there exist a trajectory of the first trailer such that both the first and the second subsystem are steered to the desired configuration, with the first trailer following this trajectory. The challenge is to find a parameterised family of plane curves, for each subsystem, such that their 'intersection' is not empty. Training content (objective, benefit and expected Impact) The requested training would allow the continuation of collaboration between t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DEVELOPMENT OF A NEW VACCINE AGAINST HIV: VIROSOMES INCORPORATING HIV PROTEINS' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

A safe and effective vaccine is the only way to stop the spread of HIV, especially in developing countries. Despite enormous efforts of numerous groups no convincing protective vaccine against HIV-1 has been generated so far. We suggest an alternative appr oach in HIV vaccine development: to test virus like particles composed of primary HIV proteins or recombinant proteins with native conformation which are incorporated into liposomes of the size of virions and with a lipid composition similar to the virus m embrane. The aim of the project is to develop this concept from the laboratory to proof-of concept studies in non-human primates. We recently established a novel large scale technology for generation of liposomes with desired properties and within this pro ject will adapt this technology to incorporate HIV-1 proteins into liposomes thereby stabilising their native conformation. Resulting virosomes carrying HIV proteins will be utilised as prophylactic and therapeutic vaccine against HIV-1 infection. Since th is vaccine is cheap to produce, stable and might be administered in a needle free format, this approach ideally meets the specific needs of developing countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Technology and corpora for speech to speech translation' (TC-STAR) under Sixth Framework.

assistant: **Objectives**

TC-STAR is envisioned as a long- term effort focused on advanced research in all core technologies for speech-to-speech translation (SST): speech recognition, speech translation and speech synthesis. The objectives of the project are extremely ambitious: making a breakthrough in SST research to significantly reduce the gap between human and machine performance. The focus will be on the development of new, possibly revolutionary, algorithms and methods, integrating relevant human knowledge which is available at translation time into a data-driven framework. TC-STAR is planned for a duration of six years.The first three years will target a selection of unconstrained conversational speech domains -i.e. broadcast news and speeches - and a few languages: native and non- native European English, European Spanish and Chinese. The second three years, will target more complex unconstrained conversational speech domains and European languages. Key actions will be: (i) the implementation of an evaluation infrastructure, (ii) the creation of a technological infrastructure, and (iii) the support of knowledge dissemination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Vaccine against AIDS: Centralised facility' (EVA) under Fourth Framework.

assistant: **Objectives**

To maintain and expand the Programme EVA Centralised Facility for high quality, state-of-the-art AIDS research reagents.To support through the provision of reagents key areas of AIDS vaccine research such as evaluation of attenuated SIV and chimaeric SIV-HIV viruses, naked DNA vaccines and the use of recombinant viral vectors.To support through the provision of reagents clinical trials of candidate AIDS vaccine.Proposal Summary Programme EVA (European Vaccine against AIDS) was launched in July 1989 with the objectives of supplying high quality research reagents to support European efforts aimed at developing safe and effective vaccines against AIDS and of promoting collaborative European research projects focused on vaccine development. Under BIOMED2, the Programme's activities will focus on providing European scientists with high quality, carefully characterised and evaluated AIDS reagents. The Programme's Centralised Facility at NIBSC (UK) has built up a large and valuable reagent repository and carries out quality control work on commissioned and donated reagents as well as on those produced in-house". Reagents in the repository are distributed freely to members of EU Concerted Actions involved in vaccine development as well as to individual scientists as long as appropriate justification is given. Close working links with the various AIDS-vaccine-related Concerted Actions that are being supported through the BIOMED Programme will be established and maintained and the needs of these groups given high priority. Under BIOMED 2, Programme EVA plans to maintain and expand the EVA Centralised Facility/Reagent Programme and to support the following key areas of research through the provision of reagents: - Attenuated and chimeric viruses for protection studies in the SIV m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Wind simulation in complex terrain' (1994-1998).

assistant: **Innovation**

Different atmospheric models to calculate the wind field near the surface in complex, hilly terrain shall be connected and extended to allow the simulation of the flow field ranging from the meso-beta to the micro-alpha scale. The results of simulations must be checked against observations. This is very important for wind energy calculations and dispersion of pollutants where there is a need to estimate the local wind power or pollutant concentration. These local values are affected by atmospheric processes on all scales. At the same time the possible application to many different places or real-time applications require that the calculation should be very efficient.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Function of the apo AI-CIII-AIV gene cluster in cholesterol transport and atherogenesis' under Fourth Framework.

assistant: **Concept**

- To understand the regulation of the apolipoprotein (apo) AI-CIII-AIV gene cluster and its impact on high density lipoprotein (HDL) metabolism, cholesterol transport from peripheral tissues and atherogenesis. - To develop mice and rabbits transgenic for unmodified and modified forms of the human cluster. - To develop knock-out mice in which the coding frames of individual members of the cluster have been interrupted with minimal nucleotide variations.Coronary heart disease is the major cause of mortality in the European Union. It is caused by atherosclerosis, in which there is focal deposition of cholesterol in the artery wall. Atherogenesis is influenced by plasma lipoproteins. Elevated plasma concentrations of low density lipoproteins (LDLs) accelerate the process. In contrast, atherogenesis is inversely related to the high density lipoprotein (HDL) concentration. This may reflect the role which the HDLs play in the transport of cholesterol from tissues (reverse cholesterol transport, RCT). Two of the major apolipoproteins (apos) of HDLS though to be important for RCT are apos AI and AIV, the genes which are located with the apo CIII gene in a cluster in the human chromosome 11. Most work on this cluster has focused on its individual members. However, there is good evidence that regulatory elements of each member are dispersed throughout the cluster. This project will for the first time analyse the function and regulation of the entire cluster. This will be achieved by expressing the human cluster in normal mice, hyperlipidaemic apo E knock-out mice, New Zealand White rabbits and hyperlipidaemic Watanabe rabbits. Clusters will be used that have been modified in vitro by the introduction of stop codons in the coding regions of two of the three genes, under which condi