RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Parallaxes of Southern Extremely Cool Objects' (PARSEC).

assistant: **Innovation**

We request an Incoming International Fellowship for Dr Alexandre Andrei from the Observatório Nacional (ON) in Brazil to work at the Osservatorio Astronomico di Torino (OATo) on a research program to measure the parallaxes, hence distances, of nearby sub-stellar objects. The project plan requires data treatment and analysis, the development of astrometric methods, and the astrophysical exploitation, for 148 brown dwarfs in an ongoing observational program on the Wide Field Imager of the ESO 2.2m telescope began in 2007. By the beginning of the proposed fellowship the observational program will be finishing. An extended period of close collaboration will enable the full exploitation of the images, distances, proper motions, binarity status etc. In addition to tripling the number of brown dwarf parallaxes and contributing diretctly to sub-stellar research this project will also have repercussions in many other areas of Astronomy from the evolution of the galaxy to the formation of planets. This activity will cement OATo’s world leadership in the area of ground based parallax determinations, an area of European excellence in research. Dr. Andrei is an established researcher with a global reputation in the field of astrometry and solar studies. He holds positions of responsibility in the activities of many international bodies, many with a large European involvement which will benefit by his presence in Europe, for example he is preparing a key part of the data reduction effort for the ESA cornerstone mission GAIA. The database of raw images and treated data consistently samples the southern hemisphere sky and will be a valuable source for further Brazilian – European collaborations of scientists and students. Finally, the activity of Dr. Andrei in the framework of this pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Linking biodiversity, ecosystem functions and services in the Great Serengeti-Mara Ecosystem (GSME) - drivers of change, causalities and sustainable management strategies'.

assistant: **Objectives**

The direct dependence of humans on ecosystem services is by far strongest in developing regions where poverty restricts access to resources. This dependency also makes people in developing countries more sensitive to climate change than their developed counterparts. Increasing human populations deteriorates natural habitat, biodiversity and ecosystems services which spiral into poverty and low human welfare. This calls for innovative solutions that encompass the entire socio-ecological-economic system, as recognized on a global scale in the Millennium Ecosystem Assessment. However, innovative and practical solutions require downscaling to regional levels for identifying concrete sets of drivers of change. For Africa specifically, the interplay of human population growth, land use change, climate change and human well-being is a major challenge. This project focuses on the Serengeti-Maasai Mara Ecosystem and associated agricultural areas, a region in East Africa that encompasses parts of Kenya and Tanzania. The ecosystem is world-famous for key aspects of its biodiversity, such as the migration of 1.3 million wildebeest. This ‘flagship ecosystem’ role will enhance the international interest in the project. In this project, internationally leading researchers from Norway, the Netherlands, Scotland, Denmark and Germany are teaming up with strong local partners in Tanzania and Kenya. The research will be organised in seven interlinked work packages: 1) assemble and integrate the so far separate Kenyan and Tanzanian relevant data on the region; 2) quantify the connections between human population growth, land use change, climate change and biodiversity change; 3) test how biodiversity change leads to changes in key ecosystem services; 4) quantify the dependence of human live
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Climate Change and BIRDs in the African SAVannah' (SAVBIRD) targeting Seventh Framework.

assistant: **Abstract**

Climate change is arguably the greatest threat to biodiversity today. Understanding the mechanisms that underlie climate impacts is crucial if biodiversity goals are toe be met as the global climate changes. To date, climate impact research has focussed on northern areas, yet tropical ecosystems hold most biodiversity. For the first time, this project will have the overriding objective of identifying the mechanisms of climate impacts on biodiversity in the African savannah. This objective will be met through a highly innovative combination of modelling, monitoring and empirical work, to assess the impact of changing climates (particularly water availability) on Tanzanian bird species. Working as part of the University of British Colombia’s internationally recognised research group on savannah ecology before reintegration at the University of Aberdeen, the fellow will gain the experience and training required to facilitate his establishment at a European research organisation where he will be able to develop a research group focussing on tropical ecology and climate change. The combination of high quality science and training as part of a world class research group, plus the return period after gaining these new skills will ensure that the project meets the aim of the “People” work programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New Strategies For Therapeutic Antibodies – Synthetic bispecific antibodies & Antibody-Drug Conjugates with controlled drug loading. General methods for unexplored ADCs and personalised therapies.' to be submitted under Horizon 2020.

assistant: **Abstract**

Antibody-Drug Conjugates (ADCs) are revolutionary next-generation therapeutics. The number of ADCs in the clinic is constantly growing with four of them having now reached the market. Despite this great promise, the complex structure of antibodies results in drawbacks for their reliable modification to construct ADCs, thus impairing the full potential of ADCs. One of the major reasons for clinical failure is that it is hard to control the drug to antibody ratio (DAR) to obtain homogeneous structures. Furthermore, current synthetic methods give access to ADCs with a DAR limited to values of 2, 4 and 8, thus lowering the variety of species being tested and possibilities to balance their toxicity.  Hence, new synthetic methods giving access to homo- or hetero-functional ADCs with a high control of the DAR would be tremendous progress; being highly impactful to the ADC field and related patient outcomes.   Here, we propose innovative methods to functionalise antibodies. Based on a well-established, patented disulfide bond re-bridging method, and orthogonal click ligations, we will finely control antibody modification. This will yield: 1) Mono-functional ADCs with highly controlled DAR, including odd DARs (DAR 1, DAR 3...). This is fundamental to determine the optimal ratio between drug loading and hydrophobicity to obtain the best therapeutic activity. 2) Hetero-functional ADCs with controlled amount and site of functionalisation with different payloads. This includes production of DAR 1+1, DAR 1+1+1…several combinations of payloads are possible, paving the way to promising multi-therapies. 3) Fully synthetic bi-specific antibodies. Our method provides an unprecedented way to obtain bi-specific antibodies in a controlled and adaptable fashion from native antibodies, i.e. wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Affordable airless packaging system to disrupt the airless packaging market' in the context of a Horizon 2020 call.

assistant: **Objectives**

Airless packaging technology is the solution to a largely unsolved problem: preserving liquid food, cosmetic, pharma, and chemical products after the package has been opened. Airless packaging preserves the protective atmosphere of the package after opening and therefore, it preserves the integrity of the product from air oxidation and bacterial contamination. Ultimately, it extends product’s shelf life, reduces product waste, enables brands to use less or no chemical preservatives and create more natural products.However, current airless packaging solutions are complex, expensive, and require sophisticated filling machinery, which highly limits its scope of application to a very narrow portion of mostly upscale cosmetic products. 86% of the airless packaging market is constrained to 11% of the packaging market. The largest segments of the packaging market, food, beverages, home care, which represent 89% of the market, only in rare cases benefit from the advantages of airless technologies. IVS is a patented sealing system for flexible liquid packaging that enables to deliver the product without any air intake. IVS has all the valuable benefits of airless packaging but it has two further key benefits that may turn it into a breakthrough solution in the market: very low price per unit and low Total Cost of Adoption. IVS is intended to disrupt the airless packaging market by making the airless technology also viable for lower-price products in the largest segments of the packaging market: food, beverages, and home care. We plan to launch IVS in the market and we seek to further develop it to a market-ready product. We will use Phase 2 for this purpose, with a total investment of €1 million in 18 months. The overall plan is to commercialize IVS first in Spain and speed scal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'RNAi-mediated genome regulation' (RNAiGenReg) targeting Seventh Framework.

assistant: **Abstract**

RNA interference (RNAi) is a highly conserved, sequence-specific gene regulatory mechanism among eukaryotes. It is critical for a variety of important biological functions and is being pursued as a promising new tool for the treatment of a variety of human maladies. A surprising link between heterochromatin and the RNAi pathway was discovered a few years ago in fission yeast and plants, and similar mechanisms have more recently been described in various eukaryotes. However, to what extent the mechanisms we have been studying in yeast are conserved up to humans remains unknown. The goal of this proposal is to further our understanding of RNAi-mediated heterochromatin assembly by using fission yeast as a model organism, but also to investigate to role of RNAi in the nucleus of human cells.My proposal consists of three major aims. In aim 1 I propose to combine light and electron microscopy to address important and largely unanswered questions such as subcellular localization and temporal regulation of the RNAi pathway. Aim 2 builds on our recent discovery that RNAi factors physically associate with chromatin to control genome activity also outside constitutive heterochromatin. I am proposing experiments in fission yeast that aim at understanding the biological role of this new mode of genome regulation and its mechanistic dissection . However, we will also extend our analysis to human cells which will shed new light on the role of the RNAi pathway in the nucleus of higher eukaryotes. Finally, we are aiming at identifying the features a target locus in the S. pombe genome must have to become susceptible to RNAi-mediated silencing at the level of chromatin. Thus, the outcome of these experiments may substantially influence the developments of siRNA-based therapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Surface Modifications for advanced applications' (SUMA2-Network) targeting Seventh Framework.

assistant: **Abstract**

The SUMA2 Network is designed to collaborate in the field of materials surface modification for advanced applications, and is composed of 3 Universities and 1 research center in Europe (Saarland University and Fraunhofer Institut for Material and Beam technology (GER), National Politecnical Institute of Lorraine (FRA) and Linköping University (SWE)), and 5 Universities in Latinamerica (Universidad Nacional de Río Cuarto, Universidad Nacional del Comahue, Universidad Tecnológica Nacional (ARG), Potificia Universidad Católica de Chile (CHI), Universidade de Caxias do Sul (BRA)).The purpose of this multidisciplinary network is to combine different areas of expertise in physics, chemistry, materials science, materials engineering, mechanical engineering and electronic engineering towards the development of optimized surfaces for different applications, such as: gas sensors, transparent p-n junctions, organic solar cells, electrochemical electrodes and wear resistant and anticorrosive surfaces.To achieve this goal different processing techniques will be applied and combined, like plasma-based deposition techniques, plasma-assisted thermochemical diffusion treatments, and laser patterning. This will be complemented with excellent characterization facilities including FIB/SEM, high resolution TEM, and atom probe tomography. Moreover, specially designed facilities for property testing (electrical, mechanical, sensing) are available. 54 exchanges with the participation of 41 scientists with different levels of experience (from PhD students to professors) will be carried out within the project. The total cost of the project is 184.800 €. Three workshops will be organized in order to exchange experience among the partners, to enhance knowledge transfer as well as to discuss furthe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Atomic force microscopy-based exploration of layered double hydroxide nanoparticles adjuvant mechanism' (AFM-LDH).

assistant: **Concept**

Layered double hydroxides nanoparticles (LDH NPs) composed by divalent/trivalent metal ions are efficient vaccine adjuvants to assist antigens to induce potent humoral and cellular immunity. However, the adjuvant mechanisms of LDH NPs still remains elusive. Since the metal ion species and ratio are closely related to the adjuvant activity of LDH NPs, this study will investigate how the metal ion composition will affect the adjuvant activity of LDH NPs. Then, an atomic force microscopy (AFM)-based approach to physico-mechanically map the specific interaction occurring between NP and Toll-like receptor-4 or scavenger receptor A1 in vitro on living cells. Finally, the adjuvant signaling pathways of LDH NPs will be investigated in antigen presenting cells. This study will greatly advance the knowledge on the interplay among nanomaterials and innate immunity. The single-cell, quantitative approach can be readily applied to study the binding of other nanomaterials and the testing of anti-inflammatory molecules on living cells of the innate immune system.


**Keywords:** layered double hydroxide,  atomic force microscopy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cinematic Atmospheres: Towards a New Ecology of the Moving Image' under Horizon Europe.

assistant: **Concept**

Cinema is not just a representational but also an operational medium. Its global success is indisputably tied to its ability to embed its audience in affectively charged, atmospheric worlds and filmmakers carefully design their narrative worlds through ambient soundscapes, music, colorations, filters, camera movements, production design, mise en scne, rhythmical editing, and countless other features that arrange the emotional and affective experiences of the audience. Marginalized in film studies due to their ontologically indeterminate nature, cinematic atmospheres operate affectively and prior to cognitive, critical, and analytical reflection. This project examines cinematic atmosphere production in all its experiential, aesthetic, and ethical implications as an attractive but also problematic, even harmful, and ideologically loaded enterprise. It raises critical awareness of the basic atmospheric operations of cinema in a time when the medium is relocated into new media environments and its techniques are reused within ecologies that are not cinematic per se such as news broadcasting, videoconferencing, sports refereeing, and even terrorist recruitment. This project i) develops a broad conceptual understanding of cinematic atmospheres as a way of organizing the perceptive, affective, and cognitive epistemic access to the world of the film, and ii) mobilizes this understanding to develop a method for the study of the operations and techniques that constitute cinematic atmosphere production before iii) expanding this method to deal with the question of how these cinematic operations and techniques for atmosphere production are no longer the property of cinema alone but increasingly employed outside of the narrative-aesthetic domain at the service of larger socio-cultur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Recycling Locally Produced Bio-Wastes to Ensure Affordability and Availability of Innovative Bio-Based Fertilisers'.

assistant: **Concept**

Several studies have identified 3 main waste streams that are the most promising for being valorised to obtain bio-based fertilisers (BBFs): (1) manure, (2) sewage sludge, and (3) food chain waste. From these, manure is the largest waste stream, representing more than 70% of the nutrients, but several studies have been conducted in the last 10 years aimed at its valorisation as BBF and have shown that it is a feasible feedstock for obtaining N-rich streams and organic amendments that can be used directly as BBF, but most of them are not suitable to be used as ingredients for centralised high quality fertiliser production due to the presence of pollutants such as heavy metals (mainly Zn and Cu) and organic matter. Sewage sludge and food chain waste have not yet been deeply investigated at the levels required for industrial implementation, such that their fertilising potential is still under-exploited.The ReLEAF project is based on the advancement and widespread demonstration (in 5 technology demonstration sites) of a suite of extraction techniques to produce key BBF ingredients from waste streams prevalent across Europe – sewage sludge, fish processing waste and wastewater, mixed food waste, and agri-food residues. The formulation and production (in 2 sites) of cost-effective BBFs will address the serious issues of externalities (i.e., dependency on foreign supply chains (P and K), and petroleum-based resources (N)) from fertiliser production and use in European soils together with security of supply and waste valorisation. Investigations of the effectiveness and replicability of the BBFs within the varying climate conditions and soil ecosystems of 4 different field demonstration sites, in addition to co-creation activities, will allow for regional engagement with stakeh