RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The vivitron'.

assistant: **Objectives**

Principal characteristics of the facility and of the support offered to users: The VIVITRON is a large tandem accelerator currently operating up to 18 MV. Modifications to the charging system of the machine will take this up to 20 MV by the end of 1997. The reliability of the accelerator has recently been considerably improved under the supervision of an international technical committee. This allows the laboratory to increase the available beam time (and consequently the experimental activities undertaken) and to provide access to many new users of the associated neutron, charged particle and y-ray detectors. These are DEMON, ICARE, CHARISSA, VELOCITY FILTER and GAREL+. Up until October 1996 the laboratory hosted the y-ray spectrometer EUROGAM and will be the site of EUROBALL IV available from November 1998. The greater amount of beam time will permit the continued use of the full range of detectors after installation of EUROBALL IV. This request is, therefore, in relation to the extra outside users of the new detectors plus the additional users of EUROBALL IV who now collaborate due to the greater 'Europeanisation' of this previously bilateral French/UK project. The laboratory is also in an excellent position to provide the scientific, technical and logistical support essential for the successful participation in experiments by users who do not possess such facilities in their home institutes. The association of the above-mentioned detector systems with the VIVITRON will place the laboratory at the forefront of research activities in the domains of nuclear structure and reaction mechanisms at Coulomb-barrier energies. Quantity of access being offered and number of users who may benefit: Compared to the 1996 campaign, the expected increase in available beam time is of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Study of the folding properties of isolated fragments from fibrinolytic multidomain proteins' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

One strategy to study folding intermediates is to identify protein fragments or peptide models that fold autonomously. Fragments of proteins having lost some of the tertiary interactions that hold them in contact with other amino acids in the uncleaved protein could mimic the conformation of the early intermediates of folding. The initial aim of this project is to use a variety of techniques, including hydrogen exchange labelling coupled to NMR, and electrospray mass spectrometry, and combined with stopped-flow methods and NMR experiments, to examine the folding of a variety of protein fragments from two fibrinolytic multidomain proteins: urokinase and streptokinase. Urokinase-type plasminogen activator (u-PA), is a serine protease whose principal function appears to be the activation of plasminogen to plasmin by specific proteolytic cleavage. Streptokinase (SK) is a bactoferial secretory protein and also a potente activator of plasminogen. Both proteins are being widely used as a thrombolytic agents in treatment of acute myocardial infarction. A detailed understanding of domain interactions in these proteins will aid the design of novel therapeutic agents. Virtually nothing is known about the folding of multidomain proteins. Once the work on fragments of the proteins is complete, studies on the intact proteins can be initiated to explore the mean in which such proteins are assembled.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High precision flavour physics using lattice QCD' (HPFPLATTICEQCD) under Seventh Framework.

assistant: **Objectives**

The Standard Model (SM) of particle physics has been supported by experiment for four decades. Ongoing high energy experiments in the LHC at CERN and the Tevatron at Fermilab are pursuing the last missing element of experimental support, the discovery and measurement of the Higgs boson. Nevertheless, at the edge of the experimental program hints of possible divergence from theory have appeared, especially in the area of flavour physics,  the phenomenology (interactions and mixings) of the six types or flavours of quarks and leptons. Furthermore, the inability of the Standard Model to provide an explanation for certain phenomena such as the amount of matter-antimatterasymmetry in the Universe, or the hierarchical values of the masses and couplings strengths of fermions, has led most physicists to believe that the Standard Model is only an effective theory, that is, an approximation to an yet undiscovered, morefundamental theory. So it is that even if the existence and characteristics of the Standard Model Higgs boson are experimentally verified (recent reports are not promising), experiments at hitherto unattained energies and levels of precision will continue to be required to elucidate thephenomena that are beyond the Standard  Model(BSM).Currently there is a large experimental program providing flavour physics data in Europe, USA, and Asia: BaBar, Belle, Tevatron, CLEO; the newer LHCb and NA62 at CERN, BES-III in Beijing, and KLOE-2 in Frascati; and the forthcoming Belle-II and J-PARC in Japan. The ever-increasing precision of data from such experiments requires a commensurate increase in the accuracy of the predictions derived from theory. Development of new, as well as continued refinement of existing, lattice QCD methods is required to attain theoretical prediction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'LEarning VEntuReS for Climate Justice' (LEVERS) targeting Horizon Europe.

assistant: **Abstract**

We live in an increasingly fragmented and unequal society. Democracy is in crisis, and mistrust in science is on the rise, yet the unprecedented challenges we face, such as the climate and biodiversity crises, require greater scientific literacy and engagement across society. Education needs to provide the scientific knowledge to engender engaged and informed societies, but also to equip learners with the holistic competences to support and motivate them to become courageous thinkers and doers, actively shaping their own futures. We urgently need connected, system-wide responses that incorporate varied perspectives, are empathetic to different stakeholders’ needs and centre social justice and care. To achieve this, we need models for education that are more flexible and inclusive and advance lifelong learning to empower all citizens.  LEVERS delivers Learning Ventures, a replicable model for expansive science learning through multi-stakeholder regional partnerships that collaboratively explore challenges and design science learning experiences to address local issues. In 9 Learning Venture demonstrator regions, stakeholders from formal, non-formal and informal education across education levels, community organisations, research and innovation, industry, and government, will be supported to adopt a systemic design approach to create climate justice projects offering meaningful real-world learning experiences. Capacity building and a mentoring programme will offer role models and guidance within and between regional Learning Ventures, linking R&I with education. The LEVERS Learning Framework and Field Guide will enable the partnership model to be adapted for other regions and challenges. Professional learning programmes and Open Schooling resources will enable widespread
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Creating Economic Space for Social Innovation' (CRESSI).

assistant: **Innovation**

The CRESSI project will explore the economic underpinnings of social innovation with a particular focus on how policy and practice can enhance the lives of the most marginalized and disempowered citizens in society. Overall, the bid will take an institutionalist view of the key issues exploring the drivers and structures that lead to marginalization and disempowerment and then setting out how interventions drawing on social innovation can address major economic, social and power imbalances and inequalities. The project draws upon three interlinked strands of theory to provide an overarching conceptual framework: Beckert’s social grid model; Sen’s Capabilities Approach; Mann’s analysis of institutional power structures and their enactments. The main work packages will focus on: establishing an economic theory and context for social innovation across the EU; contextualizing social innovation within established research and practice on technological innovation; exploring emergent social innovation ecosystems and lifecycles; setting out effective policy agendas and instruments for fostering social innovation; establishing best practice metrics for capturing the impact of social innovation. In addition, discrete work packages will focus on the overall management of the project and the dissemination of its key findings and contributions. The conceptual and theoretical elements of the project will be tested and revised with a rigorous programme of empirical data collection encompassing qualitative case studies and linked quantitative analyses with a focus on key topic areas across several member states that can inform the EU Commission debates on building smart economies that reduce inequality and socio-economic marginalization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Modulating skin innervation to treat cutaneous inflammation'.

assistant: **Innovation**

Skin disease is one of the most common human illnesses. At any given time, approximately one out of three individuals is affected by skin disease and it is the 18th leading cause of health burden worldwide. Despite this profound impact, skin disease continues to receive relatively little attention in global health forums, and the etiology of most of these conditions is unclear. The skin is our major interface with the external world, densely innervated with sensory and autonomic nerve fibers. Thus, neuromodulators are involved during all phases of skin damage and healing. Nevertheless, we do not fully understand the interaction between skin innervation and skin pathologies. More importantly, the therapeutic potential contained in cutaneous innervation has not been exploited. NEUROSKIN will determine how different skin innervations affect psoriasis, a major skin disease, representing the largest class of skin conditions, those that are mediated by inflammation. We will utilize a transgenic mouse model that enables optogenetic control of local peripheral innervations using light. This model was developed as part of our ERC STG to characterize the involvement of peripheral innervation on gut inflammation. In NEUROSKIN, we will extend this tool to develop additional transgenic mice relevant to cutaneous neuronal subpopulations. In these mice, we will control the activity of neurons innervating the psoriatic plaques at different stages of the disease. This will allow us to map potential of targeted neuronal interventions to treat inflammatory skin conditions. Such characterization is expected to introduce an entire set of therapeutic tools based on neurological manipulations, and allow us to repurpose drugs and other technologies (e.g electrical and magnetic simulation) for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Driving innovation in pharmaceuticals: integrated studies of physical dissolution properties of crystalline and amorphous forms using enhanced orthogonal monitoring techniques' (CRYDIS), addressing dissemination and exploitation.

assistant: **Impact**

The CRYDIS exchange programme will establish and support international and inter-sectoral transfer of knowledge and expertise in pharmaceutical and instrument science between several EU research institutes and industrial companies. It will also enhance understanding of the value of inter-sectoral exchange mechanisms for taking research to market.CRYDIS undertakes innovative, collaborative research on the clinically-important topic of dissolution of drug substance particles in bio-relevant media and the undesired subsequent nucleation and re-precipitation of the drug prior to its absorption. Using innovative advances in UV imaging technology, CRYDIS investigates the utility of novel dissolution assays as key tools to obtain fundamental data on the mechanism and kinetics of undesired nucleation and re-precipitation during or following dissolution, a significant problem for the pharmaceutical industry which struggles to obtain sufficient exposure to poorly soluble drug substances to ensure an effective dose is absorbed by the patient. The key technologies in this proposal offer a step change in capability and functionality, offering the potential to undertake more detailed studies of the dissolution/re-precipitation processes relevant to pharmaceutical materials. Access to this key technology and the further development of its capability offers the potential for breakthroughs in development of process understanding and of robust and widely applicable protocols.Additional value is brought to CRYDIS through close working with synergistic European networks, leveraging a greater knowledge input and impact outreach. Running parallel with the science programme, an innovation management work-package analyses effectiveness of the exchange mechanism in building a shared culture, tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Eu evaluation policy' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The key objective of the workshop is to review the EU evaluation policy and to analyse the application of program evaluation in various domains (education and culture, regional policy, employment and economic development), with particular attention to the methods used and their utility for improving EU policies.The workshop is organised to promote an interdisciplinary discussion on the quality of the research that is produced in response to EU demands and on the methodological approaches that can be of use for a further development of quality program evaluation in Europe. Of particular interest is the research being undertaken by young researchers in Europe and the US and the potential utility of new approaches for the evaluation of EU programs.Another objective of the workshop is to foster the development of networks for joint research and to explore the opportunities that exist for social scientists with regard to the evaluation of EU programs. The themes of the workshop are: Policy evaluation in Europe, Professional responses to the demand of program evaluation and Policy contexts.The activities of the workshop are: Panel discussions and Symposia (to discuss major evaluations of EU programs) and paper sessions to present preliminary research results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Structural health monitoring of a suspension bridge in Istanbul, Turkey'.

assistant: **Innovation**

The proposal request funds to develop a real-time vibration monitoring and condition assessment system, i.e., a Structural Health Monitoring (SHM) system, for a suspension bridge. The bridge selected for the study is the Fatih Sultan Mehmet Bridge, also known as the Second Bosporus Bridge, in Istanbul, Turkey. We propose to monitor the static and dynamic motions of the bridge continuously by using acceleration, GPS, and rotational sensors, and develop real-time algorithms for data analysis and damage detection.One of the primary objectives of the SHM system will be to detect damage after earthquakes. We postulate that damage can be detected based on the changes in the natural frequencies of the bridge during the earthquake, plus the presence of any permanent deformations after the earthquake. The former is determined from the analysis of earthquake response data, whereas the latter is determined from the comparison of pre- and post-earthquake ambient response data. We propose to use GPS sensors and rotational sensors to measure permanent deformations. The key product of the research will be an automated structural condition assessment and damage detection software for the bridge.The project will be the first application of SHM in Turkey. The bridge is a critical lifeline in Istanbul, a city with 62% probability for a large earthquake within the next 30 years. The proposed SHM system will not only monitor the current condition of the bridge, but also provide crucial data to predict its response for future earthquakes. The knowledge and experience gained from this project will help to develop similar SHM systems for other bridges throughout Europe, leading to safer structures and reduced maintenance costs. The project will be completed by the Kandilli Observatory and Eart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A novel Androgen Synthesis Pathway in treatment-REsistant Prostate Cancer' (ASPIRE-PC), addressing dissemination and exploitation.

assistant: **Impact**

Prostate cancer (PC) is the most prevalent non-cutaneous cancer in men and leads to high morbidity and mortality. Disseminated PC is treated by hormonal treatment in order to block intratumoral activation of the androgen receptor (AR) by 5α-dihydrotestosterone (DHT). Despite this treatment, eventually all patients develop castration-resistant disease (CRPC) which is accompanied by poor prognosis. Novel androgen synthesis and receptor inhibitors improve patient survival in CRPC, demonstrating the crucial role of residual androgen presence in PC despite castration.Besides the classic DHT synthesis pathway through testosterone, recent studies in humans have shown formation of DHT through an alternative pathway that does not require testosterone as an intermediate. Activity of this alternative androgen synthesis pathway is dependent on the presence of specific steroidogenic enzymes. Results of preliminary preclinical and clinical research show that levels of alternative pathway intermediates are increased in CRPC.Our goal is to investigate the activity and relevance of this novel pathway during progression of PC. The contribution of the alternative pathway to DHT-initiated AR activation will be explored using previously established in vitro models and sensitive steroid detection methods. This translational study will serve to discover novel targets for inhibition of intratumoral DHT synthesis and subsequent (CR)PC growth.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High Temperature Solar-Heated Reactors for Industrial Production of Reactive Particulates' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main objective of the SOLPART project is to develop, at pilot scale, a high temperature (950°C) 24h/day solar process suitable for particle treatment in energy intensive industries (e.g. cement or lime industries). The project aims at supplying totally or partially the thermal energy requirement for CaCO3 calcination by high temperature solar heat thus reducing the life cycle environmental impacts of the process and increasing the attractiveness of renewable heating technologies in process industries. This will be achieved by the demonstration of a pilot scale solar reactor suitable for calcium carbonate decomposition (Calcination reaction: CaCO3 = CaO + CO2) and to simulate at prototype scale a 24h/day industrial process (TRL 4-5) thereby requiring a high-temperature transport and storage system. The system will operate at 950°C and will include a 30 kWth solar reactor producing 30 kg/h CaO and a 16h hot CaO storage. Life cycle environmental impacts of the solar-based solution in comparison with standard processes will be developed as well as economic evaluation.The project develops and merges three advanced technologies: high temperature solar reactor, transport of high-temperature solid materials and high temperature thermal storage. The synergy between these technologies lies in using the solar-treated particles as storage medium. The development of a such innovative technology for continuous particle processed by concentrated solar energy at about 950°C is unique in the world. Thanks to the solar unit integration in the industrial process (potentially combined with CO2 capture), this should result in the considerable reduction of the carbon footprint of the CO2 emitter industries and open a new market for renewable energies.


**Keywords:** High-Temperature sol