RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular origins of aneuploidies in healthy and diseased human tissues' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Chromosome segregation errors cause aneuploidy, a state of karyotype imbalance that accelerates tumor formation and impairs embryonic development. Even though mitotic errors have been studied extensively in cell cultures, the mechanisms generating various errors, their propagation and effects on genome integrity are not well understood. Moreover, very little is known about mitotic errors in complex tissues. The main goal of this project is to uncover the molecular origins of mitotic errors and their contribution to karyotype aberrations in healthy and diseased tissues. To achieve our goal, we have assembled an interdisciplinary team of experts in molecular and cell biology, cell biophysics, chromosomal instability in cancer, and theoretical physics. Our team will introduce novel approaches to study aneuploidy (superresolution microscopy, optogenetics, laser ablation, single cell karyotype sequencing) and apply them to state-of-the-art tissue cultures (mammalian organoids and tumoroids). In close collaboration, Tolić will establish assays to detect and quantify error types in cells, and Kops and Amon will use the assays on various healthy and cancer tissues. Tolić and Kops will uncover the molecular origins of errors, their propagation and impact on genome integrity, while Amon will lead the investigation of the mechanisms that ensure high chromosome segregation fidelity in healthy tissues. Interwoven in these collaborations are the efforts of Pavin, who will develop a theoretical model to describe the origin of errors and to quantitatively link chromosome segregation fidelity in single cells and tissues. Model and experiment will continuously inspire each other, to achieve deep understanding of how mitotic errors arise, how they propagate and how they impact on cell pop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hierarchical Analysis of Complex Dynamical Systems' (HIERATIC), addressing dissemination and exploitation.

assistant: **Impact**

The central aim of HIERATIC is to develop a new framework for understanding complex systems as a multi-level hierarchy of sub-systems using non-linear decompositions.<br/>To achieve this goal, HIERATIC is structured in three interlinked sets of activities: theoretical work, deriving the novel mathematics required to identify suitable non-linear state space reductions of complex systems; software development of efficient multi-scale simulation and prediction libraries; demonstrators, illustrating the power of our results – network dynamics, cell cycle simulations, social interactions in animals.<br/>The theoretical work will use unconventional approaches from topology and dynamical systems theory to derive an algorithmic approach to identifying coarse-grainings" of large complex systems. These algorithms will be used to develop highly efficient simulation and prediction tools, integrated with the world-leading software libraries MASON and PRISM. The demonstrators will show the potential application of these techniques, in a range of applications, including validation on large empirical data sets.<br/>The project brings together leading researchers in complex systems theory, biosystems, multi-agent simulation, and experimental ecology, from around the EU and USA."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative System for Electrical Energy Efficiency in industrial plants' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The general objective of EFICONSUMPTION will be focused on the development and further commercialization of an innovative system able to reduce the electricity consumption in industries in a percentage up to 40%, related in terms of unitary energy cost, by means of an optimal measurement, monitoring, smart modeling, remote control and horizontal scalable management of industrial plant production and service processes. The new solution will be a combination of a specific device able to measure the main electricity parameters at any place, and an expert system, which will receive the real time data and will be able to establish efficient consumption patterns to effectively reduce the electricity consumption. This reduction will also contribute to reduce carbon footprint and emissions. EFICONSUMPTION has the following specific objectives to be accomplished in this first stage:- To develop a business and exploitation plan adjusted to the technical and commercial features of the project, including the assessment of the cost-effectiveness and exploitation potential of the envisaged solution.- To tackle the main bottlenecks and barriers for the full commercialization of the innovative technologies, mainly related to legislative and regulatory aspects in each country.- To widely disseminate project outcomes to stakeholders and end-users, strengthening synergies with other initiatives and platforms to reach the maximum impact.- To analyse the market and business strategies in the sector in order to find the best combination of external agents and international entities to develop cooperation strategies for market exploitation and further products commercialization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multi-Objective Robust Assessment of heLicopter Improvements' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The strategic goal of the MORALI project is to improve the rotor design capability, including comprehensive analysis and evaluation skills of different designs, simulation competence at various modelling levels, and automated optimisation support. While helicopter rotor design involves many different disciplines, with often conflicting demands. However, this proposal only addresses the aerodynamic problems, taking other requirements into account by properly defined constraints.Aerodynamics of helicopters is a very demanding undertaking in itself, challenging the  underlying modelling as well as high performance computing capabilities. The tool box in this project consists of blade element models at the lower end of the methodology spectrum as well as coupled flow-structure dynamics simulations at the high fidelity side.The blade element model is to be improved by a semi-empirical modelling of dynamic stall, very important for aerodynamic performance, but also for endurance estimations. Furthermore, the wake modelling will be enhanced to represent flow phenomena generated by local wake structures better at this modelling level.CFD can benefit from the introduction of a transition model to take laminar flow at the leading edge into account. Additionally, the trim procedure will be sharpened, taking advantage of automatic trim time decision and convergence acceleration.Both are used to optimise sensibly chosen free parameters in the design process, taking advantage of a comprehensive assessment of the detailed rotor simulation results. This assessment includes acoustic post-processing of the simulations and emulates the qualified analysis of an experienced engineer, in order to attenuate artificial deficiencies in the numerical procedures involved.Finally, the developed to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Self-assembly of Helical Functional Nanomaterials' (SAHNMAT).

assistant: **Concept**

The construction of nanostructured objects of well-defined size is of outmost importance for nanotechnology to surmount claims for potential applications and exploit improved chemical, physical or biological properties of a functional nanofeatured material. Biomedical imaging is one particular field of interest for water-compatible chemical self-assembly of nanosized objects. The outlined project aims to develop a methodology for the preparation of nanostructured objects in aqueous media with the emphasis lying on the precise control over the size, shape and degree of functionalisation of the features. The goal is to build upon supramolecular helical scaffolds for the development of self-assembled functional structures in the nanoscopic range, which are to be used in magnetic resonance imaging (MRI) applications. MRI has made a significant impact to the area of diagnostic medicine, predominantly due to advances in the development of contrast agents (e.g. paramagnetic Gd(III)-complexes). We believe that a supramolecular approach based on self-assembled Gd(III) chelating molecular units can combine the benefits from both low and high molecular weight derivatives: high contrast agent efficiency or contrast enhancement on one hand, and an improved control over the pharmacokinetics on the other hand, because of the non-covalent dynamic nature that holds the objects together. Furthermore, challenges in the field of MRI contrast agents will be met by the development of multivalent target-specific structures. Advantages include the accumulation of MRI signals in a region of interest, and the combination of 1H MRI contrast enhancement with a second imaging label. 19F MRI is a highly promising probe because of the high sensitivity of the 19F nuclide and the absence of any backgro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'IL-7 dependent commitment of lymphoid progenitors to the B cell pathway'.

assistant: **Concept**

During the course of evolution, the immune system has developed to defend us against infections by creating a diverse number of specialized cell types. B-lymphocytes are produced by the differentiation of hematopoietic stem cells (HSC) into gradually more lineage-restricted progenitors. This B cell pathway requires the coordinate action of the early transcription factors PU.1 and Ikaros prior to the activation of the B-cell-specific regulators E2A, EBF and Pax5. In addition, interleukin-7 (IL-7) signalling instructs the initial differentiation of B-lymphocytes from the common lymphoid progenitor. This project will investigate how IL-7 signalling, through activation of the transcription factor STAT5, is integrated into the transcriptional control of early B c ell development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Artificial Intelligence for Smart Cities' (AI4SmartCities).

assistant: **Concept**

It is estimated that by 2050, 68% of the world population will live in urban areas, according to the United Nations. With the accelerated rhythm of population growth, the expected number of urban citizens in 2050 is close to 6.5 billion (compared to 4.2 billion nowadays). Uncontrolled urbanization  raises a significant problem, the topic of the United Nations Development Programme Goal 11: ensuring sustainable and safe growth of urban areas. This project therefore addresses a global problem. To enable smart urban planning and scalable methods for example to predict the risk of structural degradation or damage to city buildings, it is essential to create efficient tools that can analyse large amounts of data, over time (4D), to create comprehensive global urban maps. The continuous expansion of data sets poses a significant problem for data analytics for global smart urban planning: we currently lack solutions that can generate useful insights from the data.In this PoC project, I aim to extend the AI algorithms and the big Earth observation data management features developed in the ERC Starting grant to very high resolution data for Smart City applications and offer our software as a commercial, integrated service. Within the PoC, a comprehensive business case that will assist us in designing an exploitation strategy will be developed. Achieving these objectives will advance our AI solution for Smart City from a technology readiness level (TRL) of 4 to 6. Our value proposition in AI4SmartCities is a set of professional solutions for very high resolution geo-spatial and social-economic indicators for Smart City planning and management by retrieving them from big EO data using AI. For example, high resolution building footprint map, urban building change map, and traffic f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A portable device for Early detection and treatment of Traumatic Brain Injury based on advanced qEEG and HD-TES to prevent major Health problems and specially for use in emergencies and telemedicine' (EMEREEG) under Seventh Framework.

assistant: **Objectives**

Traumatic Brain Injury (TBI) is recognized as a major public health concern, especially for teenagers and young adults, since it can lead to significant disruption in education, working ability, and quality-of-life in general. It is one of the leading causes of death and disability worldwide. 1.2 million EU citizens are hospitalized with TBI each year and of which 50.000 die. The total economic burden in Europe for TBI of all known severities is estimated EUR 33 billion annually. Currently, there is no objective method for diagnosing TBI in an early stage or in emergency, which is a premise to prevent serious health impact. Our idea is to develop a portable medical device for objective and reliable emergency diagnosis of TBI and a monitored personalized treatment based on qEEG (quantitative electroencephalography) and HD-TES (High-Definition Transcranial Electric Stimulation). We propose to create innovative technology for the early detection and treatment of one of the most severe cognitive diseases for the use in emergency, telemedicine, hospitals, and rehabilitation centers. We will achieve this by 1) developing a novel vacuum based helmet device that will enable an accurate positioning system of up to 32 electrodes, 2) developing an instrumentation system that will combine qEEG recording and HD-TES treatment, 3) developing a data processing system that will control all measurements and data analysis including the algorithm for early detection and treatment of TBI. Our innovation will increase quality-of-life, improve first-aid care, and healthcare in remote and rural areas. Moreover, the society will benefit from sustainable savings in costs for healthcare and for work disability. We, the SMEs, will benefit from increased revenue and sales of the developed technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Charging and accounting schemes in multi-service atm networks' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The goal of CAShMAN is to study, develop, implement, verify and compare charging and accounting schemes for ATM networks. This will be achieved by the development of appropriate pricing models, their efficient implementation in hardware and software, and the extensive use of National Host facilities for validation and for acquiring important user feedback.Implementation of sound charging and accounting models.Implementation of hardware monitoring equipment that aims at the collection of the accounting parameters from the ATM network.Charging ATM traffic with different tariff parameters.Implementation of a Telecommunications Network Management System performing the calculations necessary to support the accounting operations.Expected ImpactRecommendations for the structure of accounting models which satisfy both user and network operator requirements.Requirements on the processing and monitoring capabilities of the network and user equipment for supporting the above mechanisms.Requirements on the architecture of the traffic shaping and policing equipment.Recommendations on the TMN architecture related to accounting management.Main contributions to the programme objectives:Main deliverablesCharging and accounting models for fair charging and economic usage of ATM network resources. Guidelines on the TMN architecture related to accounting management.Contribution to the programmeProvides recommendations for the structure of pricing models which satisfy both user and network operator requirements.Technical ApproachCharging schemes have been developed for guaranteed quality services as well as for ABR services which reflect network usage accurately and maximise the benefit of both the user and the network operator. A unifying framework is sought which encompasses these schemes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Electronic control of different working parameters of a dryer to improve the quality of harvests and to decrease energy requirements' to be submitted under Fifth Framework.

assistant: **Abstract**

In general, harvests, before being stored. Are quickly dried. Indeed, moisture is the main factor, which allows biological activity in any stored vegetal product, with a decrease in quality during storing. Actually, the measure of humidity, which persists in harvests at the end of drying, is made spot. This does not guarantee to produce lots that present a R.U. below the desired value in each part. With the application of electronic detectors in different points of the plant dryer, it is possible to check humidity and temperature in continuity and to pilot the flow of the harvests into the dryer jacket, obtaining a quick dried product with a R.U. that is below the desired value in each part. This solution may assure the quality of harvests and reduce the risk of fermentations and of mycotoxins production.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PANORAMIX: Platform for the operAtion aNd Optimization in ReAl-time of MIXed autonomous fleets .' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall objective of this project is to provide the first Matching, Dispatching and Routing platform for the operation and optimization of autonomous vehicles (AVs) fleets.AVs will be widely adopted in the coming decade reaching 20 million fully deployed AVs by 2025, making the mobility industry to face the following challenges:•AVs are not a mobility service by themselves as they are not capable of responding to the trip demand or adhering to a schedule while adapting to network disruptions.•Mixed (different brands and types of vehicles) and hybrid (AVs and human-driven vehicles) fleets will co-exist and currently there is no solution available for mixed and hybrid transportation planning. •Due to digitalization and automatization the growing demand for public transport is becoming more user centered.PANORAMIX responds to these challenges by bringing to the market the first vehicle agnostic platform allowing mobility service providers to operate hybrid and mixed fleets, and optimize the whole transport system by answering real-time demand in combination with fixed routes. Customers can benefit from a turnkey solution, using the relevant web and mobile application from PANORAMIX Marketplace, from an integrated solution, using the ITS capabilities to power their own web and mobile applications, or from using it as an interface to the backend an existing platform and add compatibility with AVs and optimization capabilities.PANORAMIX will increase ride-sharing by allowing on-demand operations, increase safety through continuous monitoring, provide optimized routes and alternative solutions in case of traffic disruption, enable energy conservation and emission reductions by optimizing the use of the fleet and charging scheduling, and contribute towards a more inclusive