RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New approaches in diabetes gene therapy' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Diabetes mellitus is the most common metabolic disease in humans. All forms of diabetes, both inherited and acquired, are characterized by hyperglycemia, an absolute or relative lack in insulin, and development of diabetes specific microvascular pathology in the retina and renal glomerulus, neurological complications and macrovascular complications. Fatima Bosch's group has developed three transgenic animals models expressing PEPCK/glucokinase, PEPCK/myc and PEPCK/insulin chimeric genes respectively, at hepatic level. These animals remain normoglycemic despite a destruction of B cells, suggesting that engineering extrapancreatic tissue to express these genes during diabetes might be an useful approach of gene therapy for diabetes. This project is focused on the use of these three chimeric genes for the establishment of new therapeutical approaches of diabetes. In conclusion, this study will provide informations about the feasibility of the gene therapy in human diabetic patient.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Vaccination based on the recombinant ad35 adenoviral vector and ad5fib35 chimeric vector.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Crucells research training will involve the investigation of the possibilities to develop recombinant Ad35 as a vaccine delivery vehicle. The Vaccine Research Department will execute the following projects: a) Generation of a vector system and adenovirus packaging cell lines to produce high titered stocks of replication deficient Ad35 virus and subsequent in viva testing of efficacy and toxicity of these vectors, and b) investigation of the efficacy and safety profile of Ad5fib35 vectors in in vivo models (rodents, non-human primates). Although recombinant Ad35 is regarded as the vector of choice for vaccination it will be necessary to further investigate the Ad5fib35 chimeric vector because extensive knowledge, obtained in the past years in pre-clinical and clinical studies with Ad5-based vectors, is lacing for Ad35-based vectors, The advantage of Ad5Fib35 is that these vector can be efficiently produced at pharmaceutical scale with Crucells existing production technology. Safety, toxid, and efficacy studies with Ad5Fib35 will need to be executed to generate valuable information concerning the use of Ad35 based vectors in different vaccination programs. The general aim of this research project will be to develop antigens resulting in protection upon infection (prophylactic vaccination) or even eradication of diseased cells (therapeutic vaccination).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ultra-low dose of IL-2 for the treatment of recently diagnosed type 1 diabetes' (DIABIL-2), addressing dissemination and exploitation.

assistant: **Impact**

ConceptThe discovery of regulatory T cells (Tregs) has revolutionized our understanding of autoimmune diseases. As T1D is caused by the failure of Tregs to block autoimmune destruction of pancreatic ß-cells, Treg stimulation has the potential to stop the process, preserve ß-cells’ insulin secretion, and likewise prevent or delay disease progression and improve clinical outcome for patients.BackgroundLow-dose interleukin-2 (ld-IL2) was recently shown to stimulate Tregs without stimulating effector T cells. In NOD mice, ld-IL2 can prevent and cure T1D. In humans, (i) we showed that ld-IL2 is safe, induces Tregs and is associated with clinical improvement in patients with autoimmune vasculitis; and (ii) we performed a dose-finding study in T1D to define an ultra-low dose IL-2 (uld-IL2) that is well tolerated and induces Tregs’ numbers and functionality.With this strong background – a well defined mechanism of action; proof of concept in NOD mice; proof of principle in a clinical trial with another autoimmune disease; safety and activity/efficacy data in T1D – we propose a phase-II clinical trial testing the efficacy of uld-IL2 for preserving ß-cells.MethodThis will be a double-blind randomised placebo-controlled, age-stratified (6-35 year), multicentre European trial assessing efficacy and safety of uld-IL2 (0.5M IU/m2/day with a maximum of 1 MIU/m2/day for adult patients) in 138 recently-diagnosed T1D patients. Our methodology strictly follows the Immunology of Diabetes Society consensus recommendations and European regulatory guidelines. The primary end-point is the change from baseline of AUC C-peptide during a mixed meal test at 1 year. The trial is precisely and conservatively powered to detect an effect size of d=0.5.ImpactsIf successful, this trial will have profoun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tribo-electric cable plastics recycling', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives and content:In cable recycling most effort is put in the recovery of metals. Cables are shreddered, the metal liberated and removed. However, 45% of the weight of the cables consists of plastics, mainly PVC (70%) which are put to landfill (400.000 tons/year in Europe). The reason for not recycling PVC, although it is very high quality PVC, is that rubber is present in the plastic scrap. PVC and rubber have the same density range and until now there is no technical solution available for separating these two plastics in large quantities. When a PVC-rubber mixture is re-processed, the rubber degradates and causes air bubbles resulting in a low PVC quality. The aim of this project is to recycle the PVC. The quality will be so good that it can be reused in cables again. In this project PVC will be separated from rubber and PE using the tribo-electric charging phenomenon. Tribo-charging is the process in which two bodies are contacted and separated again with the result that each body becomes opposite electrically charged. Scouting tests have shown very promising results but not reliable, probably due to different charging conditions and differences in input material. Therefore, very important in this project is the development of a novel pre-treatment and charging of the plastics mixture to ensure selective and constant charging so separation can take place with a PVC grade >99.5%. To remove the last percentage of metal and cross-linked rubber, melt filtrationis the most suitable technique. Current problems for introduction are the high price for this upgrading (purification) step and relative long metallic wire still passing the filters causing electrical inferior PVC. In this project a combination of a cascade metal detection and a novel labyrinth filter will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Artificial Intelligence-driven, Decentralized Production for Advanced Therapies in the Hospital' (AIDPATH) under Horizon 2020.

assistant: **Objectives**

AIDPATH (Artificial Intelligence-driven, Decentralized Production for Advanced Thera-pies in the Hospital) is a high-energy EU consortium, dedicated to enable and to augment the next-generation of personalized medicine at EU hospitals through the use of AI tech-nology. The exemplary embodiment of gene-engineered immune cells in AIDPATH will be T cells expressing a synthetic chimeric antigen receptor (CAR-T). These cells are already a revolutionary novel treatment in hematology and oncology, and will also be useful for treating infections and autoimmune diseases. Conventional CAR-T therapy is complicated by complex logistics from centralized manufacturing facilities, inflexible manufacturing and clinical use schemes that disregard patient and cell characteristics, thus limiting patient access and therapeutic outcome. AIDPATH will apply top-notch AI technology to integrate patient-specific data and biomarkers in CAR-T therapy, and apply flexible manufacturing schemes to obtain CAR-T cell products with optimal fitness and anti-tumor potency. AI technology will be applied in pre- and in-process controls to reduce cost and hospital resource utilization and to augment patient access. AIDPATH will establish a role model that integrates the hospital in a smart manner, incorporating aspects of logistics, capacity planning, data management and cybersecurity by design. The project is designed to enable smart ‘bedside’ provision of personalized treatments and to accomplish end-to-end automation of hospital-based CAR-T manufacture. A key deliverable in AIDPATH will be an integrated cyberphysical infrastructure for rapid dissemination of the ‘smart CAR-T manufacturing and clinical use’ concept to hospitals throughout the EU. AIDPATH brings together a world-class consortium to address
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The natural K, Fe, and Cu isotopic response to Pt-based chemotherapeutic drug resistance in ovarian cancer', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Cancer is the second leading cause of death globally and in the EU, and was responsible for an estimated one in six deaths in 2018. Early diagnosis plays an important role in determining cancer treatment outcomes, but the diagnosis of ovarian cancer poses significant challenges; the routine screening of asymptomatic average-risk women is not recommended by any professional society. Chemotherapy using Pt-based compounds (e.g. carboplatin, cisplatin) is a standard treatment, but tumours that are initially responsive may develop chemoresistance, resulting in treatment failure. The ability to predict patient response towards post-operative treatments would allow for ineffective treatments and harmful side effects to be avoided and alternative treatments to be commenced at earlier stages. Several mechanisms underlying tumour cell resistance have been identified so far, including the altered expression of ion channels (Na, Mg, K, and Ca) and Fe-, Cu-, and Zn-binding proteins, but these remain poorly understood and it is unclear whether they can be exploited as markers of resistance. To that end, I will apply high-precision isotopic analysis by multicollector-inductively coupled plasma-mass spectrometry to Fe, K, and Cu to understand processes and determine whether changes in the natural abundances of these isotopes are associated with the development of resistance to Pt-based chemotherapeutic drugs in high-grade serous ovarian cancer (HGSOC), the deadliest gynaecological cancer, which accounts for ~70% of ovarian malignancies. Deviations in natural isotopic abundances signal biochemical changes (affecting the extent of isotopic fractionation accompanying some biochemical processes) occurring as a result of a disease in a systematic and reliable way. Through ovarian cancer cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Dynamics in magnetic nanostructures'.

assistant: **Concept**

The goal of this proposal is to organize a coordinated effort between university and industry partners to study the fundamental limits and possibilities of ultra fast spin- and magnetization dynamics and switching and to explore the potentials of newly developed switching mechanisms for applications in magnetic and magneto-optic data storage and retrieval. Traditionally, the process of magnetization reversal, which is the basis of all applications of magnetic or magneto-optic data storage, is considered to be a relatively slow process limited by domain wall motion and/or spin-lattice relaxation times (~0.1- 1 ns). The development of femtosecond lasers however has opened a completely new area in magnetization dynamics that has delivered exciting results like laser-induced changes in magnetic properties on a picosecond timescale. We will address this exciting and challenging new field by a combined experimental and theoretical approach by leading groups in the fields of spin-electronics and dynamics, organized along the following lines:1. Optical excitation of magnetic systems far above their Curie or Neel temperature2. Generation and shaping of ultra fast magnetic field pulses3. Exploration of fast polarized current induced switching The results of these studies will contribute to the understanding of spin and magnetization dynamics beyond the spin lattice relaxation, will have important implications for high speed magnetic recording and reading, will promote transnational cooperation between research teams and will in this way also promote the scientific and technological cohesion of the community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Collective Infectious Units and the Social Evolution of Viruses' (Vis-a-Vis).

assistant: **Concept**

A widely accepted view in virology is that virions function as independent infectious units. However, recent work by us and others indicates that viruses are often transmitted as more complex structures, such as virion aggregates, lipid vesicles or protein matrices harbouring multiple infectious particles. This demonstrates that viruses can be transmitted as “collective infectious units”, in sharp contrast with the current paradigm. Critically, these recent discoveries now set the stage for the evolution of social interactions, a previously unappreciated facet of viruses. I propose to investigate how collective infectious units drive virus social evolution using state-of-the-art tools from the fields of virology, genetics, structural biology, and nanotechnology. The effects of collective infectivity on viral fitness will be tested directly using experimental evolution and genetic engineering, and confirmed in vivo. Three widely different viruses will be used to achieve generality: human enteroviruses, a vector-borne rhabdovirus, and a baculovirus. Furthermore, the implications of virus social interactions for the maintenance of genetic diversity, evolvability, virulence evolution, and the emergence of drug resistance will be investigated. Radically new processes such as the putative extracellular fusion of viral particles will be also explored. I expect that infectious units constituted by viruses from different species will be uncovered as well, with far-reaching implications for epidemiology. It is becoming increasingly recognized that parasite sociality is a disease determinant, and our results may therefore inspire new antiviral strategies. In sum, this project aims at laying the foundations of virus sociality from a mechanistically-informed, bottom-up approach. Imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of bioprocesses for the conservation, detoxication and valorization of coffee pulp' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The global objective of the project is to recycle the coffee pulp and coffee husk by biotechnological processes.General objectives of the research are :* transformation of fresh coffee pulp into a stable and detoxified lactic acid silage product;* utilization of the lactic acid silage for food and feed purposes and metabolite or enzyme production. Elimination of an agro-industrial pollutant in Latin America;* recycling of coffee husk for mushroom and metabolite production;* biodegradation of toxic compounds (caffeine, polyphenols);* diversification of people's activity and employment in rural coffee-growing areas;* optimization of infrastructures and personnel employment in coffee areas.Expected OutcomeMexican applications will concern the pulp produced by wet processing, Brazilian studies will use coffee husk produced by the dry processing with or without steam pressure treatment. Improvement in coffee agro-industry processes, leading to less contamination for the environment, and an increase in quality and aditionnal sources of benefits are a priority for Mexico and Brazil.For Brazil, it is important to know what could be the potential utilizations of husk residues of coffee, before or after the steam-explosion process which allows to increase the biodigestibility and possible applications in mushroom production.For Mexico, ensiling of coffee pulp and its further utilization could avoid the rapid degradation of the material, turning quickly into a very important source of contamination of the waters in coffee agro-industrial area. The stabilized and detoxified coffee pulp could be further utilized during the non crop season as animal feed, mushroom, fungal enzymes or metabolite production.* Microbiological studies of coffee pulp silages (microbial ecology, biodiversit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multi-level synthesis and optimization for reconfigurable hardware', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The objectives of the proposed research include: (a) developing a multi-level framework and tools for automated design synthesis and optimisation, and (b) extending this framework to cover designs involving run-time reconfi- guration. At the lowest level, we plan to improve the development and analysis of library components. At the intermediate level, the low-level information will be used in the selection and parameter instantiation of components for composite designs. For this task, we will explore the use of different constraint-satisfaction techniques. At the highest level, designs will be synthesized from parts of conventional software programs. Additionally, the advantages of run-time reconfiguration will be explored at all levels and integrated in the developed tools. The feasibility of executing analysis and synthesis tasks on-the-fly will be investigated to optimise run-time adaptability and performance. We will evaluate the effectiveness of this approach using case studies of industrial interest. Training content (objective, benefit and expected impact) The project will significantly improve the applicant's knowledge and experience of reconfigurable hardware design. The research group at the host institution is recognised as an international centre of excellence in this field, and it has outstanding expertise in both theoretical and practical aspects of reconfigurable computing not available in the applicant's home country. Links with industry / industrial relevance (22) The host institution has ongoing collaborations with various industrial partners, including Xilinx, Hewlett Packard, Sony, Smith System Engineering, Loughborough Sound Images, and Interval Research. This will provide access to the latest technology and to indust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Islay wave power plant' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives of the Project - To construct one shoreline oscillating water column wave power device with three columns giving a plane water area of 170m2. - to install one counter rotating Wells turbine generator module with two generators of 250kW each giving a combined name plate capacity of 500kW with a peak electrical output of 750kW which in conjunction with pressure relief, will accommodate pneumatic powers up to 3MW, - connect to the electrical distribution grid and run the plant as a power station during the final phase of the work producing an average annual output of up to 1,800MWhrs in a year with an average resource of 20kW/m, - fully instrument the plant, monitor the performance of the power transform wave to wire and compare with the predicted values obtained from the physical and mathematical models, - provide the necessary information to improve the design of future wave power plant with a view to commercialisation of the technology both in Europe and World wide. Technical Approach A novel construction method will be adopted in which the water column chambers will be cast on a slipway formed in the coastal rock10m in from the shoreline. Thus the construction site will be protected from most sea conditions by the natural solid rock wall which will be removed when construction is complete. The water column chambers will be constructed using a combination of steel-concrete composite sections, modular pre-cast units and in-situ concrete to demonstrate how units could be mass produced in future replications using a standard design. The turbine will comprise a pair of Wells rotors mounted on individual generators allowed to counter rotate. A modular construction approach will be used with interchangeable parts. Ease of maintenance, robust construction and duplic