RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Creating Eco-efficient producer services.' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The overall purpose of this project is to bring the topic of eco-efficient services into the mainstream of European business and policy-making by examining their broad characteristics and possibilities for and barriers to their development and provide practical tools for both large companies and SMEs to identify opportunities to introduce them. The main focus is on eco-efficient producer services, i.e.business-to-business-perspective. The specific objectives are to: - develop a conceptual model of the key elements involved in the developmentof eco-efficient producer services - identify the drivers for the introduction of selected eco-efficientproducer services - assess the impact of selected eco-efficient producer services on organizational competitiveness and employment - compare and contrast eco-efficient producer services with those in finalconsumer/tertiary services - identify corporate level barriers which create barriers to the developmentof eco-efficient producer services - identify policy barriers to the development of eco-efficient producerservices - develop practical tools, e.g. checklists and workbooks, which can be usedby organizations and entrepreneurs The project will: 1. Clarify understanding and develop conceptual models of an important economic and environmental issue. 2. Provide policy makers with a clearer understanding of the importance and nature of eco-efficient services and the ways in which they can influence its development. 3. Provide the business sector with practical tools which they can utilise to identify and assess eco-efficient service opportunities. 4. Provide insights into the actual and potential contribution of eco-efficient producer services to the attainment of sustainable development. The service sector is becoming more important i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Exploring Cellular Dynamics at Nanoscale'.

assistant: **Concept**

EXCELL is a novel innovative approach to explore interaction mechanisms between biological materials and systems/nanostructures. It involves a forward-looking cross-disciplinary and design-based research to generate an integrated, biologically inspired technological platform of high complexity, able to monitor cell dynamics at nano-scale. Expertise in cellular and molecular biology, nanosciences, material engineering, biophysics, biotechnology, modelling, and analytical chemistry, are combined to address the targeted goals, which go beyond the state of the art methods used in traditional biotechnology and systems biology. EXCELL will provide  a complete Lab-in-a-Cell (LIC) sensor and actuator platform, which is capable of: (1) studying single cells in their natural environment surrounded by other cells or a complex mixture of different cells/tissue, (2) following the dynamics and interdependence of single cell processes from gene, protein, metabolite to compound secretion, exocytosis and cell-to-cell communication, (3) testing how and where various stimuli affect the different levels of the molecular machinery and finally (4) programming cells to be able to differentiate into a particular phenotype. A major task is the design of suitable biocompatible nano/bio interfaces that ensures a sustainable cellular environment. EXCELL provides a unique opportunity for developing advanced, novel experimental tools to address fundamental problems of stem cell research and poses a potential for possible diversification and modulation of developmental programs of stem cells to differentiate them into specific phenotypes. EXCELL has the capacity to drive new discoveries having a significant impact not only in the field of stem cell research and clinical use, but also on molecular eng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Size effects in fracture and plasticity' in the context of a Seventh Framework call.

assistant: **Objectives**

Understanding how materials respond to external mechanical perturbation is a central problem of science and engineering. While for most practical purposes it is useful to idealize the mechanical response of a material as a deterministic function of the externally applied perturbation, disorder and fluctuations are unavoidable, leading to sample-to-sample variations and non-trivial size effects. The size dependence of strength is a well known but still unresolved issue in the fracture of materials and structures. The difficulty in addressing this problem stems from the complex interplay between microstructual heterogeneity and long-range elastic interactions. Furthermore, in micro and nanoscale samples, the plastic yield strength displays size effects and strain bursts, features that are not present in macroscopic samples where plasticity is a smooth process. Large fluctuations both in fracture processes and in microscale plasticity make the use of conventional continuum mechanics problematic and calls instead for a statistically based approach.  These problems are becoming particularly important in the current miniaturization trend towards nanoscale devices, since the relative amplitude of fluctuations grows as the sample size is reduced. In this project, concepts and tools of statistical mechanics  are used to address size effects and fluctuations in the irreversible deformation and failure of materials. The general objective is to provide a quantitative theory that can be used as base for setting reliable safety factors. The theory will be based on the renormalization group and will be guided and validated by large scale numerical simulations such as molecular dynamics, discrete dislocation dynamics and disordered network models. Finally, we will analyze experimental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MEDITERRANEAN SHIFTS IN SEAWEEDS AND SEAGRASSES FUNCTIONING' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Anthropogenic global change is rapidly transforming ocean conditions, leading to rising sea surface temperatures, ocean acidification, and more frequent extreme climatic events. These changes are reshaping marine ecosystems compromising essential services like food provision and coastal protection. The Mediterranean shallow rocky reefs, faces particularly severe impacts with intense global warming and frequent marine heatwaves, making it crucial for studying the rapid shifts in species composition and ecosystem functioning. The aim of the MEDSHIFTS project is to quantify and to predict how these changes impact seaweeds and seagrasses’ functioning, one of the most diverse taxonomic categories in the Mediterranean Sea, through a combination of 3 processes and 10 traits including calcification rate and the morphological form. MEDSHIFTS will rely on the synergy of my expertise in statistical modelling and benthic functioning with extensive expertise in assessing the effects of mass mortality events on rocky benthic habitats of the host (Dr Garrabou). This will be complemented by the essential expertise in traits-based approaches, seaweeds and seagrasses communities, meta-analyses and risk assessments of the three secondment supervisors and one close collaborator (Dr Teixidó, Dr Cebrian, Dr De Bello, and Dr Claudet). By being trained in seaweeds and seagrasses ecology and latest approaches to analyze functional shifts (e.g., Trait Probability Density), I will provide scientific basis on shifts in seaweeds and seagrasses functioning under present and future climatic scenarios in the Mediterranean Sea. MEDSHIFTS outcomes will significantly contribute to inform and enhance policy-making and decision-making processes, supporting the implementation of ongoing restoration programs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ENDPD- SLOWING DOWN PARKINSON’S DISEASE PATHOLOGICAL PROGRESSION.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Patients and society expect that technical and scientific advances can provide novel improved answers to address unmet medical needs. Parkinson's disease (PD) is the 2nd most prevalent neurodegenerative disorder in the world, with profound economic and social impacts. The absence of preventive therapies to tackle PD, requires the development of new therapeutic strategies. For Pharma companies, aiming to develop molecules for Parkinson Disease (PD) and other neurologic disorders, Fastprinciple is developing a new drug candidate, to be used as a future therapy to slow-down PD progression. Unlike alternative solutions (such as the ones commercialized by Bial, Acadia Pharmaceuticals, Abbvie, Lilly, and others), which target the symptoms, we expect to slow down the disease progression, increasing current therapies’ effectiveness overtime. PD affects more than 10 million people globally and has an enormous social and economic burden.  Current treatments manage the symptoms of the disease but do not offer the patients the possibility of a cure. Unfortunately, as the disease progress to higher debilitating stage, the patient stops responding to the current symptomatic therapies, ending without therapeutic options. We have identified a molecule that with the company’s patented reformulation technology will improve the drug efficacy and slowdown the disease progression of the disease.  The current proposal aims to establish FastPrinciple’s Strategic monetization plan, by securing IP strategy and to ameliorate our business and exploitation plan.


**Keywords:** Neuroscience,  Chemistry,  Chemical Engineering,  Psychology,  pharmacokinetic-pharmacodynamic modelling, Animal Pathophysiology,  Medical Device,  Parkinson’s Disease,  Ionic Liquids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular and metabolic effects of transgene insertion in plants and response to abiotic stress' in the context of a Sixth Framework call.

assistant: **Objectives**

The use of genetically modified plants raises a number of scientific issues as the evaluation of modifications at genetic and metabolic level induced by the transformation. The glucocorticoid receptor (GR) is a hormone-receptor transcription factor in vertebrates that is activated by gluco-corticoids, having anti-inflammatory and immunosuppressive benefits. Transformants of Nicotiana langsdorffii plants containing the gr gene showed alterations in the morphology and development.A previous analysis allowed the detection of differences in the transgenes copy number but sequence homology of the transgene insertion sites. Detailed analysis suggested that the insertion of gr in the genome of Nicotiana led to qualitative differences in DNA methylation patterns that are known to regulate transcriptional activity and development. In order to better understand the effects of gr transformation in Nicotiana plants, the METRIC project aims to perform a comprehensive analysis at molecular and metabolic level of the different transformants.At the same time, plants will be exposed to environmental stress using as example heavy metals with different physiochemical property and functions. This approach will allow a preliminary understanding of the molecular and metabolic effects of the transgene insertion and its role in plant-abiotic stress interaction, gainful goals not only for the biotechnology scientific community but also for all the scientists of related fields, including plant-abiotic stress interactions. The main objective of METRIC is to reintroduce the candidate in multidisciplinary high quality scientific laboratories of the country of origin, giving training in several technical skills and benefiting of the experience acquired during the previous Marie Curie fellowship. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flightworthy Flush  Lightweight doors for unpressurized Fast Rotorcraft' (FRCDoorDemonstrator), addressing dissemination and exploitation.

assistant: **Impact**

In the JTI Clean Sky 2, the Fast Rotorcraft Project (FRC) aims at demonstrating that the compound rotorcraft configuration opens up to new mobility roles that neither conventional helicopters nor fixed wing aircraft can currently cover. These advanced rotorcraft concepts aim at high cruise speed, low fuel consumption and further benefits for operators as well as the society. The 4 doors will be developed in order to provide flightworthy flush & lightweight doors for an unpressurized Fast Rotorcraft demonstrator. The applicants are proposing latest state-of-the-art FRP composite  technologies & design methods as well as support the topic manager up to test & certification documentation  as well as a flight test survey.The major challenges include the development of a preliminary concept from concepts up to flightworthy demonstrators at TRL6 for all four types of FRC doors. Pivotal questions relate to material selection, production methods as well as quality assurance in the context of innovation & sustainability in the aeronautical branche.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Identification of new cancer susceptibility genes by linkage analyses in Polish families with aggregation of breast or colorectal cancers'.

assistant: **Concept**

International Hereditary Cancer Centre (IHCC), Szczecin, Poland is institution organised in order to perform basic and clinical studies on hereditary cancer. During 11 years of its activity, IHCC achieved several world-class goals. One of them is registrat ion of more than 3000 of families with strong aggregation of different types of malignancies. In around 1000 of them it was possible to find constitutional mutations in one of major cancer susceptibility genes such as BRCA1, BRCA2, MSH2, MLH1, MSH6, APC an d others. However, in around 2000 of registered families constitutional mutations have not been detected. In order to achieve it and to use the enormous unique potential of IHCC in identification of new cancer susceptibility genes, it is crucial to develop in this centre linkage analyses - one of the most powerful methodology of finding genes involved in pathogenesis of inherited disorders. World-class scientists - D. Goldgar from Lyon and P. Peltomaki from Helsinki (known fortheir great contribution in wor k on identification of BRCA1, BRCA2 and MSH2 genes) expressed their interest instudies with the use of linkage analyses aimed to identify novel cancer susceptibility genes in families registered by IHCC with strong aggregations of breast and colorectal can cers.The complementary experiments will be performed on 47 large families (including 6 with biological samples available from at least 10 affected relatives) at IHCC (by experienced researcher recruited for 2 years and a few members of IHCC permanent staff ), Lyon and Helsinki (by two outgoing post-doc fellows from IHCC) under supervision of D. Goldgar and P. Peltomaki and project co-ordinator.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissecting the Role of Chromosome Instability in Cancer' to be submitted under Seventh Framework.

assistant: **Abstract**

Chromosomal instability (CIN), the inability to correctly segregate sister chromatids during mitosis, is a hallmark of cancer cells. Overexpression of the mitotic checkpoint protein Mad2, commonly found in human tumors, leads to CIN and the development of aneuploid tumors in mouse models. However, recent observations from various laboratories suggest that aneuploidy can promote or suppress tumorigenesis depending on the context. This proposal aims to understand the relationship between aneuploidy and tumor formation and to identify in what context aneuploidy acts oncogenically and those in which it acts as a tumor suppressor. We propose to generate inducible mouse models that recapitulate the aneuploidy state of human tumors, to investigate the role of CIN in promoting or suppressing cancer.In addition, we have shown that CIN facilitates escape from oncogene addiction (the dependence of tumor cells on their initiating lesion for survival) and may be responsible for tumor relapse after targeted therapies. Due to the clinical relevance of these findings, we will investigate how CIN potentiates oncogene independence. It is possible that some CIN cells in the primary tumor are already independent of the initiating oncogene prior to treatment. Alternatively, CIN cells are more susceptible of acquiring additional mutations and evolve to become independent of the initiating lesion. We will develop an innovative three-dimensional in vitro culture system to isolate and characterize surviving cells after de-induction of the transgenes. It is necessary to understand the molecular mechanisms that lead to CIN and the consequences it has in tumor initiation, suppression and relapse, hoping that the genes or proteins identified could be targeted therapeutically.Finally, if human tumor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Disability and social mobility in Johannesburg' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Since the end of apartheid, the role of racial categories in the reproduction of inequalities appears to have decreased in South Africa but, the extent of these changes remains debated. This project aims to renew our understanding of these processes by adopting a transversal approach to understanding post-apartheid society. To do so, I will attend to the life trajectories of people who live with a physical disability: a departure point that will allow me to engage with individuals from various racial and class backgrounds.As a counterpoint to statistical surveys on social mobility and to the Marxist tradition of social class in South Africa, I will draw on Bourdieu’s multidimensional analysis of the social space to articulate the impacts of racial and social categories, but also of disability and gender, on professional careers. I will also question how expectations and claims for support impact on disabled people’s careers, based on an analysis of social configurations as forms of interdependency that have ambiguous effects on disabled people’s professional trajectories. For instance, could the delegation of care to women explain why women with disabilities find work less easily than their male peers? Therefore, this project also aims to integrate the issue of disability within the study of social mobility.The outgoing phase at the University of Johannesburg will help me foster my knowledge on current social sciences debates in this country, extend my network with local researchers and conduct ethnographic research (60–80 biographical interviews with disabled people and 6–9 study cases of social configurations based on observation and interviews). In return, the acquired knowledge and the research results will serve as a comparison point during the incoming phase for r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Evolution and fairness in the theory of monetary integration'.

assistant: **Innovation**

My research project aims to elaborate a theory of monetary integration as an evolutionary process in which countries care about fairness and reciprocity.Recent studies have shown that the optimum currency area (OCA) theory- fails to explain countries decisions regarding their participation to the European Monetary Union (EMU), and- has little or no predictive or explanatory capacity.This calls for the need of an approach bringing new lights on the decisions processes and taking into account the strategic behaviours of countries operating in a complex environment of trade and globalization.I would like to propose an evolutionary approach in which monetary union, as a common economic institution, emerges from the interaction of sovereign countries over time when consideration such like fairness and reciprocity matter.A theory of how countries decide to integrate a monetary union may improve proposals to reform institutional structures, which in turn contributes to the success and the stability of the monetary union area.