RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative gene therapies for epilepsy treatment' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A significant part of the costs of neurological diseases on society is associated with epilepsy. About 30-40% of the patients are refractory to pharmacological treatments, which are mostly symptomatic and often have side effects. In few cases surgical intervention is considered and no treatments interfering with or preventing the development of epilepsy are currently available. In this context, EPIXCHANGE aims at exploring, providing the basis for clinical application and implementing in the industrial arena new and unconventional strategies for the therapy of partial epilepsy advancing the state-of-the-art in the field. To achieve this, a strategic partnership will be created, including two internationally recognized academic institutions (UniFE, ULund) and one SME (NsGene) developing encapsulated cell biodelivery (ECB) based therapeutic products. ECBs will be transferred to the academic partners, while knowledge and technology on animal models, viral vectors and BDNF-producing cells will be transferred to the SME.This partnership will implement a joint research programme, which will enable to exploit the complementary competencies and technologies available at each participant site and will increase the knowledge-sharing and technology transfer, as well as the mutual understanding and penetration of the different cultural settings and skills required for both academic and industrial sectors, thus improving partners’ RTD capability and competitiveness.This will be combined with transfer of knowledge on complementary skills. Experienced researchers will be also recruited to bring top level experience in techniques that are not present in the consortium. Annual workshops will be organized to benefit the transfer of knowledge programme and the dissemination of results bot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A novel gene therapy for epilepsy'.

assistant: **Concept**

The aim of this project is to clinically validate CG01 as a novel gene therapy for the treatment of drug-resistant epilepsy patients.Epilepsy affects approximately 50 million people worldwide. 6 million Europeans are afflicted by the condition which annually costs around EUR 15 billion in France, Germany and the UK alone. Current standard of care entails anti-epileptic drug (AED) therapy. However, up to 30% of epileptics (20 million people worldwide) are unresponsive. Research to date has shown that adeno-associated virus (AAV) vector-mediated upregulation of the human neuropeptide Y (NPY) and its receptor Y2 inhibits epileptic seizures. This has inspired CG to develop CG01, a type of advanced therapy medicinal product based on the introduction of genes that encode human NPY and Y2 via the AAV vector into the brain cells of epileptic patients. AAV has already been shown as clinically safe and validated gene delivery system. The current project aims to translate promising findings in animal research into valid human data by bringing CG01 through a Phase I/II trial in drug resistant epilepsy patients. This will be the basis for further clinical development and commercialisation of the product.CombiGene’s strategic operations are currently aligned to establish CG01 as a novel epilepsy treatment. This innovation has the potential to revolutionize treatment for epileptics by delivering a treatment that may cure rather than just alleviate symptoms. Developing CG01 is integral to the company’s growth and this project is therefore essential in fulfilling the company’s long term vision.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced next generation Mobile Open Network' (ANEMONE).

assistant: **Innovation**

The current challenges of the Internet are to accommodate future needs and usages such as billions of fixed and mobile users and devices, reliable transport of all type of data and ubiquitous, seamless and uninterrupted access. This results in a growing demand of researchers and developers for an open testbed to validate new complex applications, services and devices in a mobile and wireless context. Thus, the primary goal of the ANEMONE project is to provide them with such a playground and help inventing tomorrow's world.The ANEMONE project will realize a large-scale testbed providing support of mobile users and devices and enhanced services by integrating cutting edge IPv6 mobility and multi-homing initiatives together with the majority of current and future wireless access technologies. It will be made of existing testbeds and extensions covering campus and metropolitan areas with a large spectrum of real end users for a pertinent evaluation of advanced services and applications. It will also offer a wide range of multimodal and open terminals such as laptops, PDAs, smartphones and an e-vehicle with a mobile router and local devices.The ANEMONE testbed will first of all be used by the ANEMONE consortium members for research activities in the domain of advanced mobility and multi-homing and related security issues. However, the testbed will also be open to external researchers and propose a complete infrastructure of service facilities to help RandD teams to focus on their studies rather than on setting up an enhanced test network.The ANEMONE testbed will be modularized in order to facilitate extensions and enhancements. Thus, arbitrary elements of the testbed can be easily replaced by new developments of the ANEMONE consortium or external researchers. Finally, the AN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Process identification and clustering for transparency in reorganising public administrations' (PICTURE) under Sixth Framework.

assistant: **Objectives**

A large potential for process reorganisation with ICT lies within European Public Administrations (PA). Especially municipal administrations fail to exploit this potential because decision makers in PA hesitate to invest in process reorganisation projects and the necessary ICT infrastructure.This is because the potential impact of ICT on processes is usually unclear and hence large investments cannot be justified to the political leadership and the public. The result is that PA focus on the optimisation of single processes with low budget ICT and without a coherent ICT strategy. Without such a strategy most of the reorganisation potential mentioned above remains unexploited.PICTURE aims to develop a decision support system which is capable of measuring the potential impact of ICT on back-office processes in municipal PA. ICT in this context are basic ICT components which are necessary for back-office reorganisation and have influence on many processes. Examples are workflow management systems, document management systems or optical archives.The impact will not be determined based on single back-office processes but based on a consistent view on all public services and their underlying processes which we call the process landscape. In order to cope with the complexity of ICT and the large number of processes in PA two abstraction layers will be introduced: Structural analogies and common elements of the processes will result in so called process building blocks. The functionality of basic ICT components will be consolidated to groups of ICT functionality.The potential impact will be determined by matching ICT functionality groups on process building blocks and expressed in a qualitative, a quantitative and a monetary dimension. PICTURE will enable decision makers in Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Climate proofing future forest management' (CLIMPRO) under Horizon 2020.

assistant: **Objectives**

The overall objective of this study is to quantify how adaptive management can affect the provision of ecosystem services,focusing on wood production, river runoff and climate change mitigation. The study will enhance our understanding of howadaptive management can contribute to climate change mitigation or, on the contrary, may exacerbate climate change whilesustaining forest-based ecosystem services.


**Keywords:** Ecosystem modelling, abrupt tree mortality, natural disturbance, adaptive management, earth system, model, coupled simulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The World's First Safe and Efficacious Human Blood Substitute: HbMP-700, a Haemoglobin based oxygen carrier, based on bovine blood.' (HbMP-700).

assistant: **Innovation**

CC-Ery GmbH develops HbMP-700, the world’s first substitute for human blood as a source for red blood cell (RBC) transfusions. 85 Mio. RBC transfusions are used p.a., representing a 10-15nb€ market. They are used to compensate for blood loss during surgery, treat patients with haematological malignancies, as well as victims of accidents, natural disasters, and military conflicts. The only source for RBC transfusions today are voluntary human blood donors. This leads to frequent supply shortages in the EU and other major healthcare markets. Donor blood must match patient blood. It can only be stored a few weeks, adding to the critical supply situation. Developing countries face a more severe situation as they cannot afford the standard of care of the developed world. In addition, human blood bears the risk of contamination with infections. HbMP-700 is extracted from bovine blood – a nearly unlimited, low cost supply source. It is transformed by a patented purification and manufacturing method to a lyophilized powder that is as effective as RBC transfusions from human blood, but bears no risk of infection, can be stored for months, and can be given to patients of all blood types. Bovine blood from one major EU slaughterhouse is sufficient to produce enough HbMP-700 to supply global demand for RBC transfusions. CC-Ery implemented the manufacturing method on a laboratory scale and is currently conducting preclinical trials, so far with excellent results. The objective of the SME Phase I project is to develop a business plan for the market introduction of HbMP-700. For this, a technological, regulatory, and economic feasibility analysis will be conducted. In Phase II, it is planned to build up a GMP (Good Manufacturing Practice) compliant manufacturing process and subsequent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Assessment of African Vegetation Resources: New Perspectives from Satellite Passive Microwave Datasets' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Livelihoods of most of the African population strongly depend on local ecosystem services, such as grazing, agriculture, firewood, and construction timber. Although an overall greening trend is shown by both dynamic global vegetation models (DGVMs) and Earth Observation (EO), large uncertainties for each data source are reported and significant divergence between outputs have been documented, impeding accurate assessment of vegetation dynamics in Africa. The overall purpose of this project is to develop methods to for an improved assessment of African vegetation resources based on new capabilities originating from satellite passive microwave observations. Specifically, the vegetation optical depth (VOD) derived from passive microwave data is sensitive to the water content in both the green and woody (i.e., branches and stems) vegetation components which is different from the traditional optical-infrared greenness driven vegetation index (VI) being primarily sensitive to chlorophyll abundance. By combining multi-frequency VOD retrievals with long-term VI datasets, in situ measurements, and DGVMs, this project will accurately quantify woody biomass, green biomass, net primary production (NPP), vegetation phenology and ecosystem functional types (EFT) in Africa, as well as their long-term changes and the climate and socio-economic drivers. The results are expected to pave the road for improved vegetation resource management in Africa and understanding of global carbon cycling. To achieve this, I will be trained in cutting edge skills (EO time series, flux measurements and ecosystem modeling). My major mobility activity will be sparking the integration of passive microwave VOD, carbon and water flux measurements and DGVMs for an improved understanding of changes in vegetati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of intestinal antigen-presenting cells in generating T cell-mediated antifungal immunity' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Intestinal fungi are an important component of the microbiome and their homeostasis/dysbiosis constantly shapes the immune responses. The human commensal fungus Candida albicans colonizes the gut of 40-80% of individuals. However, life-threatening infections caused by this fungus are relatively rare since the unwinding of its pathogenic potential is kept in check by the immune system. In line with this, immunodeficient patients suffer often from Candidiasis, which is typically difficult to treat. Candida albicans induce strong Th17 response which is the main protective mechanism against pathogenic fungi. Candida-induced Th17 cells can protect the host not only against other fungal but also against extracellular pathogens. Besides the positive effects of Th17 in defence against pathogens, recent studies connect fungi-elicited Th17 response with local and gut-distal pathologies such as asthma, multiple sclerosis, Crohn’s disease, or rheumatoid arthritis. Despite that the role of Th17 is relatively well studied, the early events at the initiation of innate and adaptive immune responses against intestinal fungi are much less known. Various mutations in the adaptive immune system are clearly associated with impaired antifungal immunity. The proposed project will fill this knowledge gap by systematic studies of antigen-presenting cells involved in initiating Th17 response upon Candida colonization. We propose to use single-cell RNA sequencing techniques to determine Candida responsive populations followed by deletion of MHCII on selected APCs populations to prove that the effect is mediated via antigen presentation. We will further study the bidirectional interaction between Candida and APCs in these mice. This study will lead to the understanding of events at the beginning o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synergies in medical informatics and bioinformatics' (SYMBIOMATICS).

assistant: **Concept**

Bioinformatics and medical informatics are both rapidly advancing fields. Advances in molecular biology, the home of bioinformatics, demand that it reaches out to the biology of cells, tissues, organs, organisms and populations. Within medicine, increasing understanding of the molecular basis of disease, and the effect of genotype on disease propensity and treatment efficacy, create a convergence between the disciplines.This project is an information gathering and dissemination activity which will stimulate these developments and exploit the synergy between bio- and medical informatics. A collaboration between national and international policy-making organisations will document the state of the art in biomedical informatics and identify areas of maximum opportunity. This will be done by systematically identifying European experts (using the so-called snowball" methodology) and collecting their insights. Initially this will be done through an open-ended consultation whose output will be used to create an Internet survey from which results will be summarised and presented.Simultaneously, bibliometric and data-mining methods will identify and analyse the content of the relevant scientific literature. Areas of opportunity will be extracted from the resulting information, and meetings of the partners and experts will carefully prioritise these. A report summarising the findings will provide well-judged input to future European scientific and funding policy. A concluding meeting will present these findings for discussion by a wider community of bio- and medical informaticians."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Welfare reform and the management of societal change' to be submitted under Fifth Framework.

assistant: **Abstract**

European welfare systems differ markedly; all face common pressures. Existing research tells us much about what reforms are needed. We know much less about how to achieve change in the context of different national policy-making systems. This project will conduct detailed analysis of recent policy changes and of the anticipated trajectory of future reform, based on expert policy review and interviews with key actors. It will investigate how the different policy-making frameworks of EU states facilitate, obstruct or divert reform. It will chart the extent of modernisation to meet new needs and indicate opportunities for the EU to give a lead in welfare. The project will improve understanding of policy-making processes and of how to implement policies to sustain the European welfare achievement.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sustainable trade in ethical aquaculture' in the context of a Seventh Framework call.

assistant: **Objectives**

Trade in aquatic products is the largest global food sector, by value, and Asia represents the main external source of aquatic products into the EU. Current EU policy supporting international trade between Asia and Europe concentrates on issues of food safety as measures of quality, whilst market-forces drive development of standards and labels that identify social and environmental parameters. This project proposes to establish an evidence-based framework to support current stakeholder dialogues organised by a third party certifier. This will contribute to harmonising standards, helping consumers to make fully informed choices with regards to the sustainability and safety of their seafood. The ‘Ethical Aquatic Food Index’, a qualitative holistic measure of overall sustainability to support consumers’ purchasing decisions, will be based on detailed research centred around a Life Cycle Assessment of current processes involved in ensuring aquatic products reach consumers, aligned with analyses from the sustainable livelihoods approach and systems thinking. SMEs based in the EU will participate in this project, particularly the action research phase, enhancing their relative competitiveness. By strengthening the knowledge base surrounding EU-Asia seafood trade the project will provide the evidence required to support further expansion whilst ensuring a fair deal for producers who are meeting appropriate social and environmental goals and offering a safe and sustainable product for consumers. The sectors covered represent the main aquaculture products reaching EU markets; tilapia, catfish, shrimps and prawns. Known case study stakeholders include SMEs in Bangladesh, China, Thailand and Vietnam where sustainability is essential in the face of rapid growth. The research will