RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on '“Multi-component nanoparticles as bimodal contrast agents for MRI and optical detection of tumors and for targeted photodynamic therapy”'.

assistant: **Innovation**

The main aim of this proposal is to synthesize a range of lanthanide containing nanoparticles with an upconverting  core, that can be excited in the infrared region to yield emission in the visible range, as  for MRI and optical imaging. The nanoparticles will be covered with a rare earth doped MRI active shell and decorated with targeting moieties, which offers a means of targeting cancer cells that greatly over express the receptors.  Further we will develop “phototheranostic” agents by anchoring the photo active anti cancer drug in between the receptors and the surface of upconverting/MRI active nanoparticle. A platform for synthesis of water soluble, modular target specific bimodal agents based on nanoprobes will be developed that will exhibit  efficient upconverted photoluminescence from the rare-earth ions (Er3+/Tm3+) doped into fluoride nanomatrix. Simultaneously, the Tb3+/Dy3+/Ho3+ present at the shell will make them suitable as T2 contrast agents for MRI. Specific tumor targeting strategies will be developed by attaching targeting components like folic acid, cholesterol or cyclic-RGD to the surface of the nanoparticles. Functionalization of nanoparticles with [Pt(N3)2(OH)2(NH2-R)(py)] drug, which can  be photoactivated by the blue light emitted from the nanoparticle core upon excitation at 980, will result in a novel phototheranostic anti-cancer agent. This system may allow a large degree of control of the therapeutic efficacy and ultimately lead to simultaneous diagnosis and treatment in clinical applications. The unique multidisciplinary approach adopted here which combines areas of nano-chemistry, spectroscopy and bio-imaging, is expected to lead to a disruptive change in the area of cancer research. The combination of these areas would allow for the first t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ab initio approach to nuclear structure and reactions (++)' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Today, much interest in several fields of physics is devoted to the study of small, open quantum systems, whose properties are profoundly affected by the environment; i.e., the continuum of decay channels. In nuclear physics, these problems were originally studied in the context of nuclear reactions but their importance has been reestablished with the advent of radioactive-beam physics and the resulting interest in exotic nuclei. In particular, strong theory initiatives in this area of research will be instrumental for the success of the experimental program at the Facility for Antiproton and Ion Research (FAIR) in Germany. In addition, many of the aspects of open quantum systems are also being explored in the rapidly evolving research on ultracold atomic gases, quantum dots, and other nanodevices. A first-principles description of open quantum systems presents a substantial theoretical and computational challenge. However, the current availability of enormous computing power has allowed theorists to make spectacular progress on problems that were previously thought intractable. The importance of computational methods to study quantum many-body systems is stressed in this proposal. Our approach is based on the ab initio no-core shell model (NCSM), which is a well-established theoretical framework aimed originally at an exact description of nuclear structure starting from realistic inter-nucleon forces. A successful completion of this project requires extensions of the NCSM mathematical framework and the development of highly advanced computer codes. The '++' in the project title indicates the interdisciplinary aspects of the present research proposal and the ambition to make a significant impact on connected fields of many-body physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Blood Vessel Development and Homeostasis: Identification and Functional Analysis of Genetic Modifiers' to be submitted under Horizon 2020.

assistant: **Abstract**

The vascular system is a complex network of blood vessels that transports gases, nutrients and hormones throughout the organism.  Most blood vessels that form during development and growth arise by the sprouting of new capillaries from pre-existing vessels, a process termed angiogenesis.  An imbalance in angiogenesis contributes to the pathogenesis of numerous disease states: insufficient angiogenesis limits tissue recovery in ischemic disease, whereas stimulation of angiogenesis by cancer cells promotes tumor vascularization and growth.  Angiogenesis inhibitors are already in clinical use for anti-tumor therapy; however, multiple reports of resistance are calling for the identification of additional targets.  Furthermore, vascular malformations are a significant cause of morbidity and mortality.  While the genetic basis for some vascular malformations is known, many genetic factors, including modifiers that affect the age-of-onset and severity of phenotypes, remain to be identified.  Identifying modifier genes is important not only to fully assess genetic risk, but also to provide novel targets for therapy; however, identifying modifier genes has proven challenging.  We recently uncovered a novel and simple way to identify modifier genes.  By investigating gene and protein expression differences between knockout (mutant) and knockdown (antisense treated) zebrafish embryos, we found that mutations in specific genes, including some encoding angiogenic factors, lead to the upregulation of compensating (i.e., modifier) genes while knocking down these same genes does not.  We hypothesize that the modifier genes identified through this approach in zebrafish also play important roles in humans.  Thus, we will use this simple strategy to identify new genes that regulate vascul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Innovative Self-healing Chalcogenide Catalysts for Green Hydrogen Production'.

assistant: **Objectives**

Electrochemical water splitting (WS) to produce hydrogen has been recognized as an up-and-coming technology for storing zero-carbon electricity generated from intermittent and non-dispatchable renewable energy sources. Among water electrolyzers, the emerging anion exchange membrane water electrolyzers (AEMWEs) are the most promising, combining efficiency and sustainability. Although it is an attractive technology, it is not yet mature and needs to be further improved to meet market needs. One of the main bottlenecks is related to the efficiency and durability of the WS catalysts. In this context, INNOSHEAL project (INNOvative Self-HEALing chalcogenide catalysts for green hydrogen production) aims to develop new WS catalysts, free of critical raw materials (CRM-free), highly efficient, and durable thank to self-healing groundbreaking properties. The innovative strategy is based on developing a design that allows for a large number of Fe-, Ni- and Mo-based catalytic active sites and an auxiliary system that promotes material self-healing due to the presence of a subnanometric layer of chalcogenide (S-, Se-, Te -based) sites. To ensure the successful achievement of project goals, the project will be conducted at ICB-CSIC, the Spanish National Research Council, with operando investigation during a secondment at PSI in Switzerland. The expected results of this proposal will primarily concern new knowledge on catalytic properties and self-healing characteristics, together with a contribution to the reduction of hydrogen production costs and the elimination of CRM dependency. The resilience of hydrogen-integrated energy systems is crucial for a reliable energy transition in Europe and will consolidate Europe's leadership in this field. Moreover, this project will help the rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Securing Critical Energy Infrastructures SUCCESS - Securing Critical Energy Infrastructures' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Living in a safe and secure society is a fundamental human need.  The security of critical infrastructures must be maintained so that supplies of power, water or other resources are secured.  Modern critical infrastructures are increasingly complex and they are turning into Cyber-Physical Infrastructures because ICT is growing in importance in infrastructure management.The SUCCESS project will develop an overarching approach to threat and countermeasure analysis with special focus on the vulnerabilities introduced by Smart Meters. The main challenge is to create the conditions in Europe for the future energy system to be as reliable as todays.Starting from a security by design approach and placing resiliency and survivability in focus, a new joint design of Energy Infrastructure and ICT is proposed. Following on the research results, an implementation approach is pursued based on the definition of a New-generation Open Real-time smart Meter (NORM) as a key building block. NORM aims to secure the end nodes of the energy system while providing innovative services in a customer centric grid. At systems level, a cloud-approach, based on double virtualization, is proposed.SUCCESS will provide concrete guidelines to support the design of energy systems and linked communications networks to guide short, medium and long term initiatives. Countermeasures will include specifications and open source software for Next Generation Open Real time smart Meters and Security Monitoring Centres at DSO and Pan-European levels, secure communications solutions using NFV, LTE and 5G technologies complemented by data privacy studies to ensure the acceptability of the results by consumers. Trials will be run in Ireland, Italy and Romania. As a result, new business opportunities for energy provi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Industrial-Driven Big Data as a Self-Service Solution' (I-BiDaaS) targeting Horizon 2020.

assistant: **Abstract**

Organizations leverage data pools to drive value, while it is variety, not volume or velocity, which drives big-data investments. The convergence of IoT, cloud, and big data, create new opportunities for self-service analytics towards a completely paradigm towards big data analytics. Human and machine created data is being aggregated, transforming our economy and society. To face these challenges, companies call upon expert analysts and consultants to assist them.A self-service solution will be transformative for organizations, it will empower their employees with the right knowledge, and give the true decision-makers the insights they need to make the right decisions. It will shift the power balance within an organization, increase efficiency, reduce costs, improve employee empowerment, and increase profitability. I-BiDaaS aims to empower users to easily utilize and interact with big data technologies, by designing, building, and demonstrating, a unified solution that: significantly increases the speed of data analysis while coping with the rate of data asset growth, and facilitates cross-domain data-flow towards a thriving data-driven EU economy. I-BiDaaS will achieve its goals following a methodical approach. As a first step, it has guaranteed access to real-world industry big data. I-BiDaaS will proceed with breaking intrer- and intra-sectorial data-silos, and support data sharing, exchange, and interoperability. Having done so, it will support methodical big data experimentation  by putting in place a safe data processing environment. To foster experimentation, I-BiDaaS will develop data processing tools and techniques applicable in real-world settings. I-BiDaaS will be tangibly validated by three real-world, industry-lead experiments, in the domains of banking, ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'INTEGRATED TECHNOLOGIES FOR IN-VIVO MOLECULAR IMAGING' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The goal of the project proposed here is to generate and apply novel advanced technology for non- invasive imaging of biomolecular function in living systems ranging from single cells to whole animals. Main areas for technological innovation arei) generation of new biosensors enabling novel ways of functional contrast,ii) improving resolution of microscopic and tomographic imaging systems, andiii) creating new multimodal imaging set up combining different contrast modes. It is expected that our combined effort will provide spectacular new opportunities for phenotyping functional (molecular) analysis in cells and animal models.To achieve this goal we bring together a unique consortium of leading research groups in Europe combininga) engineers, experimental and theoretical physicists (who design new and improved, tomographic and microscopic imaging devices for in vivo-imaging);b) bioorganic chemists and molecular biologists (for the design of new chemical and genetic encoded molecular probes and biosensors); andc) biologists examining fundamental questions at the cell, organ and whole animal level (thereby providing the above researches the appropriate and relevant goals for the technological innovation). The management structure of the project provides for continuous interactions and flow of information among the various participants, groups and subgroups involved in each work package. High quality training is guaranteed by the exchange of young researchers among the expert participants and by summer and other schools. Inclusion and interactions with companies active in this field are among the several means of exploitation of the expected RTD and innovation results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Industry-grade Quantum Memory Links enabling the Quantum Internet' (Welinq) under Horizon Europe.

assistant: **Objectives**

The prospect of a Quantum Internet interconnecting quantum computers & sensors via quantum information networks (QINs) promises to enable new technological & societal breakthroughs. Quantum entanglement between pairs of particles enables the prospect of absolutely-secure communications and distributed quantum computing within the QIN. However, quantum principles render classical techniques for extending range inapplicable. A Quantum Internet thus requires an efficient means of enabling reliable quantum links. QMLINK builds upon our teams work within the EU Flagship Quantum Internet Alliance (QIA) project in developing a quantum memory (QM) based upon laser-cooled ensembles of cold atoms and quantum networking protocols leveraging this technology. Welinqs QM, with a world record 90% storage efficiency, makes quantum interconnection possible. Our ambitious project goal is to develop the worlds first industry-grade QM links for QINs combining high-efficiency & long storage time with integrated frequency conversion for interfacing with optical telecommunication bands. Welinqs QM addresses the critical need for quantum repeaters essential for secure, fast communication at long distances. We have a well-defined plan to achieve TRL6, while attaining storage times at least an order of magnitude beyond state-of-the-art for high-efficiency QM, which will greatly increase the maximal ranges & capabilities of QINs. We will integrate our QM link solution in the QIN test-bed deployed throughout the Paris region (ParisRegionQCI) to demonstrate our system at a TRL6 level, showcase our product to potential customers & key QIN industry players, and gain invaluable insight towards realizing the Quantum Internet. EIC support will accelerate our translation of cutting-edge research into ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biological origins of linguistic constraints' to be submitted under Seventh Framework.

assistant: **Abstract**

The linguistic capacity to express and comprehend an unlimited number of ideas when combining a limited number of elements has only been observed in humans. Nevertheless, research has not fully identified the components of language that make it uniquely human and that allow infants to grasp the complexity of linguistic structure in an apparently effortless manner. Research on comparative cognition suggests humans and other species share powerful learning mechanisms and basic perceptual abilities we use for language processing. But humans display remarkable linguistic abilities that other animals do not possess. Understanding the interplay between general mechanisms shared across species and more specialized ones dedicated to the speech signal is at the heart of current debates in human language acquisition. This is a highly relevant issue for researchers in the fields of Psychology, Linguistics, Biology, Philosophy and Cognitive Neuroscience. By conducting experiments across several populations (human adults and infants) and species (human and nonhuman animals), and using a wide array of experimental techniques, the present proposal hopes to shed some light on the origins of shared biological constraints that guide more specialized mechanisms in the search for linguistic structure. More specifically, we hope to understand how general perceptual and cognitive mechanisms likely present in other animals constrain the way humans tackle the task of language acquisition. Our hypothesis is that differences between humans and other species are not the result of humans being able to process increasingly complex structures that are the hallmark of language. Rather, differences might be due to humans and other animals focusing on different cues present in the signal to extract rel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dissemination and Exploitation of GRids for Earth sciencE' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The DEGREE project is proposed by a consortium of Earth Science (ES) partners that integrates research institutes, European organisation and industries, complementary in activity and covering a wide geocultural dimension, including Western Europe, Russia and Slovakia. The project aims to promote the GRID culture within the different areas of ES and to widen the use of GRID infrastructure as platform for e-collaboration in the science and industrial sectors and for select thematic areas which may immediately benefit from it. DEGREE aims to achieve this by showing how GRID services can be integrated within key selected ES applications, approaching the operational environment and shared within thematic community areas. The DEGREE project will also tackle certain aspects presently considered as barriers to the widespread uptake of the technology, such as perceived complexity of the middleware and insufficient support for certain required functionality. The ES GRID expertise, application tools and services developed so far will be promoted within the DEGREE consortium and throughout the ES community. Collective Grid expertise gathered across various ES application domains will be exchanged and shared in order to improve and standardise on application specific services. The use of worldwide Grid infrastructures for cooperation in the extended ES international community will also be promoted.