RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SYstemic Risk TOmography: Signals, Measurements, Transmission Channels, and Policy Interventions' (SYRTO) targeting Seventh Framework.

assistant: **Abstract**

During the second half of 2011 sovereign and banking risks increased in the Eurozone in an environment of weakening macroeconomic growth prospects. Contagion effects have become substantial also accelerated by the interplay between vulnerability of public finances and financial sector. Furthermore, bank funding pressures increased markedly thus feeding the fear of the Euro crash.The SYRTO project aims at exploring the relationships between sovereigns – banks and other financial intermediaries (BFIs) – corporations of the European Union with the following objectives:1.Identify the common (”fundamental”) and the sector-specific (idiosyncratic) risks, and assemble an Early Warnings System (EWS) to be used as risk barometer for each sector and countries alike, in order to identify potential threats to financial stability, and as a system of rule of thumbs by monitoring a series of leading indicators so as to minimise the possible negative impacts from systemic crises, preventing contagion effects also including the appropriate mechanisms to restore systemic crisis problems.2.Explore policy and monetary issues relative to systemic risk developing a “SYRTO Code” in order to detect a series of recommendations, also expressed in terms of EWS prescriptions, on the appropriate governance structures for EU to prevent and minimise systemic risks, and on the best mechanisms for ensuring an effective interplay between, and coordination of, macro and micro-prudential responsibilities.SYRTO is conceived, articulated and devoted to lay the foundations for a better macro-economic and monetary integration in Europe.The expected impacts of the project are directed towards the developing of conceptual and analytical underpinnings for efficient macroprudential policies in order to reshaping
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High energy neutrino astrophysics with amanda/icecube at the south pole' (1998-2002) under Fifth Framework.

assistant: **Objectives**

High energy processes in the universe are accompanied by an emission of neutrinos. Their detection on earth can be carried out with the use of underwater/ice Cherenkov detectors. Fundamental information on active galactic nuclei, gamma ray bursts as well as on dark matter can be extracted from the study of these neutrinos. The AMANDA neutrino telescope is the most sensitive high energy neutrino observatory operative. It is composed by strings of photomultipliers (PMTs) placed deep in the ice of the South Pole. PMTs, encapsulated in glass spheres, collect the Cherenkov light produced by neutrino induced muon or cosmic ray muons. The future of the experiment, named Ice Cube, will have an effective area of one square kilometer.With the current technique, a significant amount of Cherenkov photons are lost owing to the optical properties of the PMT encapsulating glass. The development of a system capable to maximize the collection of the light is the object of the project here proposed. This can be obtained through the selection of a suitable wave length shifter (WLS) and through its integration with the encapsulated PMT. Via Monte Carlo simulations we propose also to study the impact of the hardware development on critical detector parameters like effective area, angular and energy resolution etc. and, more general, to estimate the improved sensitivity of Ice Cube to neutrino detection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Safety of GFR through innovative materials, technologies and processes'.

assistant: **Innovation**

Gas-cooled fast reactor (GFR) is considered as one of the six most promising advanced nuclear reactor technologies, supported worldwide by the Generation IV International Forum and ESNII in Europe. It excels in versatility, combining very high core outlet temperatures and the possibility to close the fuel cycle, allowing for very efficient and sustainable electricity and industrial heat production.The SafeG proposal presents a Research and Innovation action aiming at connecting developers of the ALLEGRO reactor (V4G4) with European and international experts having experience in GFR and HTR research, who will utilize  their unique expertise, knowledge and experience, bringing fresh ideas to the GFR development to the SafeG project will bring the GFR research and development in Europe a major step forward.It is divided into 7 Work Packages, four of them dealing with open research and development problems of GFRs, namely the core safety and proliferation resistance (WP1), advanced materials and technologies (WP2), decay heat removal (WP3), standardization and codes (WP4). Additionally, a major part of the effort (15 % of the total budget) will be dedicated to education and training activities sheltered by WP5. Dissemination and outreach activities are included in WP6 while WP7 ensures smooth management and execution of the project.  The main objectives of the SafeG project are:-To strengthen safety of the GFR demonstrator ALLEGRO-To review the GFR reference options in materials and technologies-To adapt GFR safety to changing needs in electricity production worldwide with increased and decentralized portion of nuclear electricity by study of various fuel cycles and their suitability from the safety and proliferation resistance points of view-To bring in students and young
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A biomechanical study of the postcranial skeleton in sauropod dinosaurs' in the context of a Fourth Framework call.

assistant: **Objectives**

Through a combination of quantitative and qualitative approaches, this project will provide a comprehensive description of the mechanical properties of the skeleton of sauropods, the largest ever land herbivores. Understanding of the mechanical design of bones, and structures such as limbs, gained through computer based theoretical modelling, biomechanical approaches and histological studies, will give new insights into how sauropods achieved giant size and the constraints this imposed. This work, combined with morphological data and fossil tracks will reveal the nature of sauropod locomotion and the function of the neck and tail. Result of these studies will provide a clearer understanding of the general ecology of sauropods and help identify links between different body plans and particular ecological niches. Extensive collections of sauropods in Berlin, London, Beijing, Moscow and the USA will form the basis of this study, which will also consider gigantism in other living and fossil land herbivores.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular interactions and cellular functions of the adf / cofilin family of actin deploymerizing factors' (1994-1998).

assistant: **Concept**

Research objectives and content I shall analyse the actin binding properties, cellular distribution and function of ADF and cofilin, essential proteins involved in cytoskeletal remodelling, e.g. in cytokinesis and locomotion. Dr Weeds's laboratory and I are each well equipped to perform this work together. We have specific antibodies for ADF, cofilin and nuclear actin raised from three different animal sources. Preparing GFP-tagged proteins will permit us to investigate: (i) cellular distribution, response to stimuli and the role of two such similar proteins in one cell (ii) the role of phosphorylation and its regulation on intracellular localization and function of ADF/cofilin and (iii) the translocation of actin and cofilin to the nucleus. Using GFP-tags will enable us to monitor these effects in real time. We shall then be able to correlate biochemical evidence with in vivo studies which neither of us are equipped to do in isolation. Training Content I have the cell biology and immunofluorescence expertise required by Dr Weeds and his group to perform in vivo analyses and in return they will instruct me further in biochemistry and the necessary molecular biology skills to prepare transfection, expression and mutated cofilin/ADF constructs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of Low Cost Cloud Monitoring for the Diagnosis and Prognostic of the Wind Turbines'.

assistant: **Innovation**

Each year, the wind sector is missing out on huge profits due to wind turbines failures of about €200 million in Spain, €700 million in Europe and €2,900 million globally. Taking operation cost into account, losses are actually triple. Adding the currently unfavorable economic situation and policies restricting the sales price, the only way for wind farms operators, maintenance companies, financial institutions, and insurance companies as well as investors to remain profitable is to improve maintenance and operation processes. Smartive is a company whose aim is to develop cloud-based software tools in order to improve the productivity of wind farms. This can be achieved based on newly available technology that allows the detection of anomalous operations by effectively programming preventive and corrective maintenance operations. Diagnosis and prognosis tools will allow adjusting operations and consequently the productivity of wind farms.The overall objective of the Phase II Cloud Diagnosis project is to scale-up our SMARTGEAR technology that allows predictive maintenance to optimize the management and operation of wind parks. Specifically, we will improve the current device by introducing communication protocols allowing extracting data from multiple devices that are placed in wind turbines and by adding transducers. Also, our SMARTCAST cloud diagnosis algorithms need to be improved. These technological improvements will allow us to roll out our solution on a global basis as we will differentiate ourselves from the competition as it will taken into account more data (not only vibration analysis), merge indicators, be cloud based rather than local and be more affordable.Based on our market research, we have forecasted the sales and defined a roadmap for commercializatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Services to enhance the innovation management capacity of SMEs in the macro-region 1 in Romania' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The objectives of this proposal are the following:Increase efficiency and effectiveness of innovation processes of localbeneficiaries of SME instrument and SMEs with significant innovation activities and high potential for internationalisation;Facilitate SME’s access to consulting services for innovation management to address bottlenecks tocreation of economic impact;Support innovative SME’s to raise the company’s profitability and competitiveness on international markets


**Keywords:** Increase the efficiency and effectiveness of innovation processes of local beneficiaries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optimal diversity in immunity – to overcome pathogens and maximize fitness; moving from correlative associations to a more mechanistic understanding using wild songbirds.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Major Histocompatibility Complex (MHC) genes are intensively studied genes in association with disease resistance. MHC proteins are essential for initiating every adaptive immune response and MHC is probably the most extreme example of how selection from a wide range of pathogens maintains high diversity in host immunity genes. However, the functions of the MHC proteins are only known in humans and model organisms, species that cannot be studied under natural conditions. There is therefore a need to study function of MHC proteins in species that can be thoroughly monitored in their natural habitat under varying pathogen regimes and over several generations. These parameters can be assessed in wild songbirds making them excellent study systems. Songbirds have large numbers of MHC gene copies, although little is known about how these affect their immune responses. Does high MHC copy number indicate that songbirds can recognize and combat more pathogens than other animals? They do fight infections satisfactory at their breeding, stopover and overwintering sites. In this proposal my overarching aim is a more mechanistic understanding for survival and fitness linked to MHC in animals from wild populations and to take this field of research beyond the simple correlative associations that hitherto have been the rule. To reach this goal I must first characterize songbird MHC, now possible with ‘single molecule real time sequencing’. Therefore a rather substantial part of this proposal is technology. I will use two different songbird study systems; long-distance migratory great reed warblers and sedentary house sparrows and malaria-like pathogens infecting both these species. I am an experienced researcher on MHC and together with my team I will (1) characterize the MHC geno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Delftia TsuruhatensTC1 Based-Intervention For Interrupting Malaria Transmission In Mosquitoes: A Novel Trial For Evaluating Alternative Tools For Control Of Vector-Borne Diseases' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Malaria eradication efforts are severely hampered by the rapid emergence and spread of resistance in mosquitoes due to widespread use of insecticide-based vector-control tools. Recently, we have published a study proposing a novel malaria intervention strategy based on the use of a bacterial strain, Delftia tsuruhatensis TC1 (TC1 for short) and its secreted active component, Harmane (HA). The TC1-intervention interrupts malaria parasite development in mosquitoes without affecting mosquito survival and fitness thereby circumventing selection of resistant mosquitoes. Extensive studies to evaluate efficacy, safety and manufacturability have been successfully completed in both, laboratory and contained semi-field settings and further validate use of the TC1-intervention for malaria control. Although, WHO has established product evaluation pathways and regulatory pipelines for insecticide-based vector control tools these are not suited for TC1 and other ‘TC1-like’ control strategies which do not fall within the ‘main-stream’ conventional category of malaria vector-control tools. To date all vector control tools have been evaluated in cluster randomized control trials (RCTs) to demonstrate epidemiological benefit but RCTs are becoming increasingly difficult and extremely expensive to conduct as standard-of-care increases the heterogeneity between clusters, diminishes the effect size of novel interventions thereby requiring higher numbers of clusters to reliably power studies. An urgent need exists for rigorous and validated entomological metrics which infer epidemiological benefit. This project aims to develop a novel trial for generating the evidence base of the TC1-intervention in open-field settings at the scale of the individual mosquito, to help support the regulatory pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The impact of Massive Binary Stars through Cosmic Times', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Massive stars, i.e. stars that are up to million times brighter than ordinary stars such as our Sun, play many important roles in astrophysics. They can be considered as (I) Cosmic Engines as they transformed the pristine and dark Universe left after the Big Bang into the modern Universe in which we live today.  We use them as (II) Cosmic Probes to study the most distant galaxies and we monitor their eruptions and explosions as (III) Cosmic Transients.  As a result, various fields in astrophysics heavily rely on the input of stellar models. Unfortunately, the widely used models are out-dated: they consider massive stars to be single. Recently, large observing campaigns with world-class telescopes provided quantitative showing that the large majority of massive stars will interact with a close binary companion (e.g. Sana & de Mink et. al. Science 2012). This project aims to investigate and quantify how binarity affects the many roles that massive stars played throughout cosmic time. Apart from a few pioneering studies, the exploration of these effects is still in its infancy. Progress has been hampered by (I) the challenging nature of the computations, (II) the many uncertainties in the models and until recently (III) the lack of observational constraints. I propose to overcome these challenges by adopting an unique and innovative approach that combines the strengths of three highly complementary state-of-the art computational tools that will be confronted directly with observational data.  I demonstrated the feasibility and high impact of this approach to derive the urgently needed constraints on the impact of binarity on stellar populations in exploratory studies (De Mink et al. 2013, 2014). In this effort I will strongly benefit from my large international network as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeted Modulation of Immune-System Responses in Cell Therapies' (MODICELL).

assistant: **Innovation**

Cell-based immunotherapies are a modern treatment approach holding promise to utilize nature’s own power to treat diseases that develop on the ground of immune system aberrations. Such diseases include cancer that develops and progresses via immune escape and on the other hand rejection of transplanted organs that need to be accepted by the immune system. Because the functions of distinct immune cell populations are highly plastic and interdependent, a better understanding of the complex regulation of immune system responses is indispensable for the optimization of cell therapies. The central goal of MODICELL therefore is to learn how to effectively instruct immune cells prior to being transferred to excite immune system responses tailored to patients’ needs. MODICELL will particularly seek to understand how to support immune activity in cancer patients by enhancing anti-cancer immunity and in transplantation immunology by inducing controlled tolerance to prevent organ rejection. MODICELL will accomplish this goal by testing agent-based models in a multidisciplinary platform combining academic expertise and industrial know-how. One academic institution will provide computer modelling to generate predictions on the interaction of immune cells under various conditions, providing hits for the other partners to test. The SMEs will use different but complementary strategies for enhancing anti-cancer immune therapies. On the other side of the immune spectrum, another academic partner will focus at enhancing tolerance in transplantation. MODICELL’s approach will enable all partners to optimise and synergize efforts to reach their goals at covering a large range of immune system responses. Thus, MODICELL will provide a highly dynamic platform for expertise and knowledge transfe