RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Advanced Sustainable Biofuels Production from Purified Microalgae and Oleaginous Yeasts via Integrated Solar Hydrothermal Liquefaction'.

assistant: **Concept**

SUNFUSION endeavors to comprehensively address a novel process of microalgae and oleaginous yeasts conversion into shipping and aviation biofuels, by advancing state-of-the-art core technologies: (i) innovative PBR and open raceway ponds for microalgae and yeasts cultivation and optimization; (ii) a concentrated solar thermal (CST)-coupled continuous hydrothermal liquefaction (HTL) reactor with solar energy covering the thermal needs of the process; (iii) a solar-aided thermal energy storage (TES) system which at later stages will be fully integrated to the overall process; (iv) hydrotreatment units to obtain the final, advanced sustainable biofuels; (v) recovery of gaseous and aqueous streams from HTL and synergistic cultivations of microalgae and yeasts that will be recycled to the microalgae cultivation leading to a zero emission and zero waste process. HTL is a thermochemical process used for the production of sustainable biofuels from the depolymerization and repolymerization of highly moist organic biomass, having the inherent advantage of avoiding the cost-intensive part of biomass drying. These points will introduce high-risk/high-return novelties that will play an impactful role in forwarding the process subcomponents to TRL 4. At least 7 L of biocrude from microalgae and 1 L from yeasts are planned to be produced and upgraded. A testing period of above 12 months will take place under on-sun conditions at temperatures exceeding 350oC, with the solar-to-biocrude energy efficiency target set to exceed 50%, which is an ambitious number that will allow the sustainable transformation of solar energy to energy carriers in the form of biofuels. Finally, an overall process assessment will take place to evaluate the technology in terms of technical, economic and environ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Investigating the pharmacokinetic properties of toxic metals and heat shock proteins as risk factors in Amyotrophic Lateral Sclerosis' under Horizon 2020.

assistant: **Concept**

Background: Exposure to toxic metals are proposed as risk factors for amyotrophic lateral sclerosis (ALS). Despite this, evidence remains mixed, with only evidence for lead exposure supported by recent meta-analysis. Many studies neglected that biomarkers may be affected by kidney and liver function. Additionally, the heat shock protein (HSP) response is triggered by toxic metal exposures, and there is evidence for altered HSP metabolism in ALS.  Methods: Using available samples (105 ALS cases, 307 controls), blood HSP’s and toxic metal exposures will be measured primarily in urine (inorganic Hg, lead, chromium, aluminium, selenium, zinc, cadmium, copper and manganese). Confounding variables such as kidney and liver function, and bone turnover will be measured. In addition, prospective recruitment of a further 100 cases and 100 controls will be carried out. For prospectively enrolees, repeat blood and urine samples will be taken three-monthly.  Statistical analysis: Multivariable logistic regression will be used to compare HSP’s at baseline, while Bayesian models will be used to model correlations between HSP’s and multiple toxic metals. Longitudinal trends will be modelled using Bayesian mixed effects models. Ordinary differential equations will be used to construct elimination kinetics models. Power calculations indicate 90% power to detect an odds ratio of 2.0 at baseline, and 87% to detect longitudinal differences in trend of 15% or more between cases and controls.  Impact: MetALS will employ new methodology to generate fresh insights into the role of toxic metals in ALS. MetALS will confirm or refute the finding of HSP’s as biomarkers in ALS, and provide the first insights into longitudinal behaviour of HSP’s as the disease progresses. MetALS will also provide the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Localized Cancer Therapy'.

assistant: **Concept**

Currently, cancer is the second cause of morbidity and death in Europe, with 1.9m deaths and 3.7m cases annually. Cancer-related deaths are projected to exceed 13m by 2030, with abdominal organs hosting most cancer incidents. Although popular, conventional modalities are nonetheless associated with major clinical challenges such as non-specificity, side effects, and drug tolerance, which impede further developments. In recent years, non-invasive, controllable, minimal side effects, and localized nano-scale drug-based therapies have been developed. This treatment deploys nanocarriers (NCs) to the location of the targeted cancer tumors, and upon activation, they release chemotherapeutic drugs. However, there are concerns over the safety of this strategy due to lack of biodegradation, potential toxicity, poor bioavailability, and limitations associated with the drug activation protocols. The main goal of the LCT project is to overcome these challenges in an original and innovative manner by developing nanocarriers that are nontoxic, biocompatible, biodegradable, and can be combined with a well-known treatment modality (e.g., a precise and effective radiation treatment). The proposed work will be approached from theoretical, numerical, and experimental perspectives based on the applicant's and host laboratory's expertise. The training program is exhaustive and will allow the applicant to grow as an independent researcher. The proposed research will foster further development in this direction, a step that is fundamental in healthcare and for the benefit of society.The applicant is a Libyan scholar with expertise in the areas of applied mechanics, industrial & medical radiation, materials science, nano-chemistry, and structural engineering. He has been trained in prestigious
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Politics of  Citizen Opposition to Urban Development' (POLICITY) targeting Horizon Europe.

assistant: **Abstract**

A central conflict in urban politics lie between those who want cities to change, physically, by embracing ambitious urban development projects, and urban conservationists who oppose such changes. The outcome of this struggle has important implications for some of the most contentious issues and concerning developments in contemporary politics. Since urban planning is often under local democratic control, local public opinion plays a central role in determining whether cities embrace or reject urban development. However, while we know much about what makes particular urban development project more or less popular, we do not have a theory that can explain why opposition to urban development varies across individuals or cities.This project advances a new research agenda to study public opinion on urban development. The project breaks new ground by developing  a novel theoretical model which argues that when housing prices in an area increase, so does opposition to urban development among its residents. The project is also pioneering methodologically, combining quasi-experimental and survey-experimental research designs with cross-city surveys that explore and explain public opinion on urban development.As key empirical contributions the project develops a new survey instrument that quantifies opposition to urban development; implements this instrument in a survey of citizens in 200 cities across Western Europe and the US; and connect these survey responses to a series of innovative causally credible research designs that provide evidence on how the housing market shape citizen opposition to urban development across cities, residences and individuals.The project will significantly improve our understanding of a salient conflict in urban politics that shape the future of ci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Single polymer visualisation in turbulent drag reduction using dna' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Addition of small amounts of polymers leads to a large reduction of the turbulent energy dissipation. This is attributed to a stretching of the Polymers by the flow, which we propose to visualize directly using singe-molecule fluorescence on DNA polymers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Changes in industrial competitiveness as a factor of integration: identifying challenges of the enlarged single european market' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The principal aim of the project is to evaluate the progress of firms in the countries which are candidates for accession to the European Union in developing their ability to compete in the world economy, illustrate the differences existing among them in this respect, and identify the related challenges facing these countries and the Single Market and policy makers. We will identify the actors responsible for changes in competitiveness and the factors underlying their role in this process, analyze the pattern of specialization and the new European division of labor emerging from changes in competitiveness, and show how these changes affect the labor market and economic growth. Policy analysis and recommendations will be an important element of the project. In addition to publications, a web site will be developed which will enhance the basis for co- operation in the European Research Area by improving the research infrastructure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Powder Plasma Arc Welding of Aluminium Alloys'.

assistant: **Concept**

In the bicycle, furniture and automotive industry the interest is centred on the use of aluminium tubes for frames. The advantage of aluminium alloys is the light weight, compared to steel tubes. However, the joining of aluminium is much more difficult than steel. The reason is the high melting, tenacious oxide layer, formed immediately on aluminium, when it is subjected to air. Brazing of aluminium is very difficult and for welding only Gas Tungsten Arc (GTA) and Gas Metal Arc (GMA-welding can be applied in production. GTAW gives the highest quality and is widely used in bicycle and furniture industry, but the process can not be easily mechanised or robotised for the thin walled tubes to be joined. So hand welding is the alternative and due to the low wages in Asia most of the bicycle frames are manufactured there. The PPAW-process has shown on steel welding, where direct current (dc) is used, to be capable of hand, mechanised and robotic welding with a quality surpassing that of GTAW. It is thought, that the same will be true for the welding of aluminium. The PPAW process, however, is so new, that the special problems for aluminium welding, e.g. welding with alternating current (a.c.) current, supply of filler material and coping with potential weld defects like porosity and hot cracking are not at all solved, yet. The aim of the project is to make PPAW suited for a.c-welding and to develop the welding procedures to join sheet, thin walled tubes, formed sheet or small diameter rods of aluminium alloys. The expected achievements for the end users (4 SME's, 1 other) are: 1. improvement of the productivity by at least 25%,2. Iower processing costs by saving of weld metal 50% and a lower energy consumption of 10%, 3 improved product quality (good appearance) and 4. lower
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identification of regulatory signals from vascular niche in alveolar regeneration and pulmonary fibrosis' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Pulmonary fibrosis is a multifaceted and fatal disease that includes damaged alveolar epithelial cells and disorganization of multiple stromal cells. Dysregulation of multicellular crosstalk between epithelial and stromal cells is likely to contribute to fibrosis. However, the precise way this tissue damage occurs is unknown. I hypothesize that impaired function of lung epithelial stem cell lead to alveolar epithelial damage in pulmonary fibrosis, and which may be caused by altered stromal/niche cells. Epithelial injury repair and regeneration in the adult lung is carried out by numerous epithelial stem/progenitor cells. Recently, I identified a crucial interaction between lung endothelial cells and lung stem cells during alveolar injury response, and demonstrated a new regulatory signalling pathway that operates in endothelial cells to support alveolar injury repair by driving alveolar lineage specification of stem cells. Importantly, introduction of endothelial-derived factors into the lung after fibrotic damage enhances alveolar regeneration and reduces pulmonary fibrosis. Given these results and unique my background knowledge, I will bring a new concept of stem cell-niche interactions in alveolar injury repair and pulmonary fibrosis. Using both in vivo murine and organoid culture, as well as human lung organoid culture systems, I will define 1) whether and how the fibrotic response affects lung stem cells and 2) how lung stem cells are regulated by endothelial cells that may comprise their respective niches during injury repair. 3) The mechanisms involved in the normal and pathological regulation of lung stem cells will be elucidated by determining secreted factors and regulatory signals endothelial cells confer through paracrine and direct physical interaction with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Resilient Legacy: Giacomo Leopardi's Zibaldone di pensieri' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project aims to offer the first systematic and comprehensive study of the impact that the publication of the Zibaldone di pensieri in 1898 has made on Giacomo Leopardi’s 20th- and 21st-century reception, and of the role the notebook has played in the reconfiguration of its author’s profile as a poet-philosopher. The project, spread over four years, is divided into three major parts corresponding roughly to three phases of interpretation that appear to be characterised by distinct patterns and/or reading strategies: 1898-1947, 1947-1998 and post-1998. The project aims to identify which precise historical, socio-cultural and technological circumstances have subtended the development of different interpretative discourses on Leopardi and the Zibaldone, and how they have operated in the course of the 112-year public history of the notebook. On the basis of this analysis, the project will also make a reliable assessment of Leopardi’s present position within the Western literary and philosophical canon, an evaluation that is extremely relevant to the current historical and cultural contingency, which features an unprecedented boom in translations of the Zibaldone into foreign languages. In addition, (1) the forthcoming publication of the first complete translation of Leopardi’s notebooks into English, which is bound to significantly facilitate the circulation of Leopardi’s knowledge outside of the Italian-speaking world and outside of the boundaries of scholarly circles; (2) the availability of internet tools such as e-journals and blogs for research purposes, of which the project will make extensive use, will help lay the basis for future research on / and experimentation with (not only) Leopardi and the Zibaldone. This includes cross-comparisons with other key figures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural effects arising from major groove dna recognition by metallo-supramolecular cylinders' to be submitted under Fifth Framework.

assistant: **Abstract**

The objective is to investigate the binding of metallo-supramolecular cylinders to DNA and to probe the remarkable structural effects induced by these cylindrical units with the goal of deliberately achieving such effects in a sequence-specific fashion. While DNA encodes the essential blueprint for life, within biological systems its structure and function is regulated by proteins. In the post genomic environment the goal is to understand the processing of the genetic code and how to stimulate or prevent this. Proteins frequently achieve DNA recognition via binding in or around its major groove since the size and shape of the major groove of B-DNA varies most with base sequence. Small synthetic recognition agents tend to target the minor groove or act via intercalation and often cause little or no bending of the DNA. Synthetic agents that target the major groove of DNA with recognition through non-covalent surface motifs have the potential to be a powerful new tool in the armoury of reagents that is being developed to tackle the post genomic challenge. Little progress has been made in this direction, due in large part to the size of the molecular surfaces required to achieve this. Supramolecular chemistry permits the design of large synthetic arrays, bridging the size-gap between small molecule and larger biomolecule DNA recognition-motifs. 3 partners in this proposal have described the DNA binding of a tetracationic supramolecular cylinder that is just the right size to fit into the major groove of DNA and too big for the minor groove (Angew. Chem., Intl. Ed., 2001, 40, 879-4). Excitingly this major groove-binding cylinder also induces a dramatic intramolecular bending effect resulting in coils of DNA that is unprecedented with a synthetic DNA binder. This proposal wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Looking for Tipping Points on Tropical Forest-Savanna Transitions' (TIPTROPTRANS), addressing dissemination and exploitation.

assistant: **Impact**

The response of tropical forest –savanna transitions has received much attention in the scientific literature over the last years. However, most studies use global models or remote sensing approaches that represent the transition from forest to savanna as a competition between a few functional groups (often just two groups: tropical grasses and tropical trees). There is plenty evidence that the transition between tropical forest and non-forest biomes is not gradual, but a threshold phenomenon between two stable states that can occur at the same level of rainfall. The switch between these two stable states has been suggested to be primarily mediated by fire, although light, nutrients and other factors can also mediate this transition.This proposal aims to gather a detailed ecological and ecophysiological understanding of the dynamic process of tropical forest-savanna transition, at a number of sites of South America and Africa. The study is framed in the context of the forest-savanna fire thresholds from a functional trait perspective, with the aim of testing and further developing the role of fire and its interaction with drought and resources availability. This will be achieved through detailed plot surveys to understand and quantify the tree mortality and recruitment processes, and through targeted manipulative experiments to understand and quantify responses to fire, drought, light and nutrient availability. This will enable the applicant to explicitly evaluate forest and savanna species’ ecological response to fire and to multiple interacting abiotic factors and provide a useful model to describe the process of possible tropical forest dieback and/or woody encroachment under some scenarios of climate change.