RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Glyco and Nano Peptide Conjugates for Selective Cell Penetration'.

assistant: **Objectives**

The next generation therapeutic agents such as proteins, nucleotides, cytotoxic agents and molecular probes hold promising properties to solve many crucial health issues. However, efficient and selective transport of this therapeutic cargos and imaging probes into the right cells at the right moment stands as a fundamental limitation of these new technologies.In this action we will develop a new generation of highly efficient, selective and biocompatible supramolecular vehicles for specific cell delivery. This strategy will consist in the implementation of dynamic bonds as linkers for glycoconjugated cell penetrating peptides. These peptide hybrids will be recognized very specifically carbohydrate receptors and internalized. These stimuli responsive dynamic bonds will assist in critical steps of the delivery process such as the cargo release and endosomal escape.We will expand this strategy to incorporate glycopeptides conjugated into multifunctional nanoparticles through host-guest interactions. We will implement state of the art synthetic, biophysics and cell biology techniques to identify new supramolecular selective membrane transporters.This action will combine the glycochemistry background of the applicant with the expertise in membrane transport of the host group. The potential discoveries will trigger new opportunities in the delivery of the next-generation probes and proteins (i.e. CRISPR).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Making Lifts Smart for More Connected and Intelligent Services.' (Smartlifts).

assistant: **Concept**

Our product SmartLifts represents an integrated solution synthesizing connectivity and security. It consists of a software-hardware suite that contains a gateway, audio modules, sensors and a management platform that meets six key needs for lifts: Increased security at reduced maintenance cost, guaranteed connectivity based on IP data transfer, maximum integration of hardware already used in lift cabins, large M2M data management capability to send and receive multimediadata, predictive maintenance and inspection applying machine learning based on expert systems, facilitated monitoring of the 74 risks defined by EN 81-80.The final SmartLifts version to be improved in Phase I) consists of: wireless connection (3G, GPRS) based on IP data transfer, integrated hardware in cabins, data volume, web application for managing emergency phone, predictive maintenance and inspection.The potential market for SmartLifts is huge considering that the global demand for lift and related services was 86 billion Euros in 2012 and is expected to grow by almost 6 % annually until 2017. There are about 5.2 million lifts in Europe alone. Our two main target groups are lift manufacturers such as OTIS, Schindler, Kone and Orona. These companies also offer lift maintenance services. The second group consists of SMEs that focus only on lift maintenance.Our overall objective for Phase 2 is to apply breakthrough Smart technology to the historically conservative vertical transport sector with SmartLifts by redesigning the existing prototype and commercializing it. In Phase I, we will create a Feasibility Study and Business Plan.We will assist in facing European and worldwide challenges improving the security of the vertical transport industry by making lifts smart. The positive societal benefits will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Patient-centered palliative care pathways in advanced cancer and chronic disease'.

assistant: **Concept**

Integrated delivery systems of care, e.g. networks of health organizations and professionals who work together to coordinate services to meet their patients’ needs, are an important  way of linking fragmented services and maximizing system efficiency and seamlessness of patient transition. Research increasingly shows that patients with advanced cancer and advanced chronic disease are treated well by integrated palliative care pathways, with comparable quality of care at lower costs. Palliative care involves the multidisciplinary care for patients in the last phase of life-threatening disease and is expected to largely grow due to the ageing of the European population. However, palliative care in Europe is still mostly organized across institutional lines: hospital, home care, hospice. This project aims at the identification of best practices in integrated palliative care with regard to quality of life and quality of care. Mixed methods will be used to identify models for integrated palliative care in Europe and to assess patient/caregiver experiences and perceptions within these pathways at the one hand and organizational, managerial, financial and regulatory aspects of these integrated pathways at the other hand. The project will evaluate existing initiatives for patients with cancer, COPD and CHF, and will deliver recommendations on (requirements for) best practices in integrated palliative care. This will also include recommendations on (changes in) skill mix of health professionals. Results will be disseminated via conferences, articles, and an interactive website including an e-learning module. This project will contribute vastly to the improvement of the (organization of) care for patients with advanced cancer and chronic disease and can be extrapolated to other p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fusion-to-Fossil Heat Exchanger for Supercritical Power Plants' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Established in 1971, our company LEADING METAL MECHANIC SOLUTIONS S.L. is a Spanish specialist in design, development and manufacturing of precision components (machined, welded, forged or casted). In recent years, we have directed our business strategy to technology and knowledge-intensive sectors – Oil & Gas, Power plants, Airspace and Defense – where we have been continually striving to get involved in highly innovative projects, large-scale scientific initiatives and new materials. We have successfully participated in the ITER project to manufacture the First Wall panels and their associated Super-Efficient Heat Exchanger. After several years of R&D work in efficient heat exchangers, we have developed an innovative “Fusion-to-Fossil heat exchanger” prototype to be integrated in Boiler Circulating Pumps (BCPs). BCPs are indeed a key component for Supercritical Coal Power Plants, which have become the system of choice in most industrialized countries due to their high efficiency (40-45%). BCPs are required in all coal power plants in order to circulate water within the boiler to enhance boiler operation. They are designed for high temperatures and high pressure, and they have the highest power demand (3.5-3.9% of the rated generator capacity) of all the auxiliary devices in a coal power plant. Listening to the power plant and energy market and the evolution of its requirements via our customers, we have identified a clear need in higher efficiency and cost optimization for their products. With our “Fusion-to-Fossil heat exchanger” F2F project, we are offering our existing BCP customers and potential customers in other sectors (e.g. petrochemical) an innovative technology achieving a 10-15% increase in system efficiency and a cost savings of up to 30%. With F2F, we wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-services Management Wireless Network With Bandwith Optimisation' to be submitted under Fifth Framework.

assistant: **Abstract**

The MAMBO project addresses the problem of managing the audio-video services distribution on the available bandwidth. It is clear that the main advantage of using digital transmission for audio-video services has been and will be the ability to use less bandwidth and infrastructure for reduced operation expenses per program. The project proposes an innovative concept and system capable of optimising the bandwidth allocation for every service, function of the complexity of the service and based on the perceived quality of the service. The activities concentrate on the development and implementation of key components of the distributed feed back loop bandwidth allocation system, which is the kernel of our open and scalable solution. The proposed architecture is the solution for service providers and mobile operators who demand a flexible and cost-effective method for managing compressed digital services while maximising bandwidth capacity but maintaining the service quality. At the service provider site, the operator is able to select specific services of interest, from a large number of TV and IP services, locally generated or arriving at its premises via satellite, terrestrial or cable networks. This solution, available in real time, enables operators to statistically remultiplex services from a variety of sources and create a new, customised statistical multiplex while optimising bandwidth for delivery of additional tiered services. A prototype, incorporating the developed key building modules, will be implemented in order to validate the new technology and to evaluate the performance and the quality of the services.OBJECTIVESThe first specific objective is the specification and development of the bandwidth optimisation remultiplexer mechanism. The second specific obje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ERECTION OF A 250 KWel/237KWth - PEM FUEL CELL PLANT FOR COMBINED HEAT AND POWER PRODUCTION IN BERLIN-TREPTOW' under Fourth Framework.

assistant: **Concept**

The aim is to show that the integration of the PEM fuel cell into district heating systems can be an ideal supplement or alternative to the established technology used in cogeneration plants. This can only be done by setting up a plant with an output comparable to what is standard in cogeneration plants. A plant of this kind has not been installed to date.The general benefits of fuel cell technology - high level of efficiency, virtually no moving parts, low noise emission levels, very low waste gas emission levels, minimum maintenance - are enhanced by the use of the PEM cell. The relatively low operating temperature of around 80°C permits the use of low-price materials and ensures a fast start-up. Moreover, the temperatures of central heating systems. The waste heat of the cell can, therefore, be used without the need for any expensive hydraulic circuits or storage facilities. This makes the cell suitable for use in small-scale district heating systems.A considerable market potential is forecast for the PEM cell in the medium term since it is well suited for series manufacture. The aim of the demonstration project is to fulfil the requirements for series manufacture. This will make it possible in the medium term to reduce the currently high specific costs of around 13000 ECU / KW to less than 1500 ECU / KWA Proton Exchange Membrane Fuel Cell (PEMFC), also know as a Solid Polymer Fuel Cell (SPFC), with an output of 250 kWel / 237 kWth is to be installed in the Berlin district of Treptow. The fuel cell is to be integrated into an existing district heating system run by Bewag which currently has an installed thermal output of 43.4 MW. The temperatures in the heating system's return permit easy assimilation of the available heat.The fuel cell is to be operated using natura
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Elaboration of an evaporative cooling technique with shear-driven liquid films' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main goal of the proposal is to elaborate a new technology for active cooling of high heat flux equipment, using thin, intensively evaporating liquid films driven by the action of a forced gas flow in a narrow channel. The main practical motivation of the project is to develop a design capability and design tools that would enable effective cooling of powerful microelectronics for terrestrial and space applications. This capability must be based upon the development of a fundamental understanding of the parameters enabling high heat transfer rates in such thin film systems. It is proposed to develop such fundamental understanding through conducting systematical experimental studies, including studies in microgravity during aircraft parabolic flights. The experiments will be performed on test sections with flat and microstructured local heaters, which will be brought to the host institution (ULB) by the applicant. ULB possesses all necessary experimental facilities to organize and study shear-driven liquid film flows. In the experiments several state-of-the-art techniques will be used (Schlieren methods, Infrared thermography, Fiber optical thickness probe, High speed CCD camera). The proposed research is supposed to make significant advances in basic knowledge of liquid film heat transfer and rupture, and eventually may lead to a new practical cooling technology with broad area of applications in the marketplace. The proposed research, as well as applicant’s scientific experience, is relevant to the research interest and activities of MRC group of ULB. MRC-ULB has close collaboration with Euro Heat Pipes S.A., aiming at elaboration and creation of an advanced film cooling system for powerful microelectronics. Part of the proposed research is in the framework of ESA-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'in vivo optogeneticS, elecTrophysiology and phArmacology with an ultRasonically-powered DUST for Parkinson's Disease' (STARDUST) under Horizon 2020.

assistant: **Objectives**

The main goal of the STARDUST project is to realize a novel wireless implantable and independent micro-scale device (200x200x200 µm3) enabling in-vivo electrophysiology, optogenetics and ultra-localized drug delivery in freely moving animals. The device will be used to target specific neural circuits of the brain and test a new therapeutic approach for Parkinson’s Disease (PD). The methods used in this project are based on cutting-edge miniaturized technology combining integrated chips, microelectromechanical systems (MEMS), local drug delivery, integrated electrodes and micro-scale light emitting diodes (µLEDs). STARDUST will benefit from these advances and for the first time provide an implantable ultrasonically-powered miniaturized device for in-vivo optogenetics, local drug delivery and electrophysiological monitoring – all in one single device. The proposed device is expected to provide an output power of 1-20 mW/mm2 for optogenetics with two different wavelengths, one for neuron activation and one for triggering drug-delivery; STARDUST will provide proof of concept.The main novelty of the STARDUST project is the convergence of multiple, interdisciplinary fields including optogenetics, triggered drug-delivery, miniaturized ultrasonic energy harvesting, material science and nanoelectronics. The main ambition of the project is to develop a new technology platform to be used for future implantable in-vivo optogenetic devices for monitoring and treating diseases, with an optional local drug delivery add-on beyond 2025. Establishing proof of concept of the STARDUST platform will be the foundation for other applications within photodynamic therapy such as cancer treatment and other neurological and non-neurological disorders.


**Keywords:** Optogenetics, Parkinson's Dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing global bioresources through the eu', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

An international workshop on Developing Global Bioresources will be organised by OIBC, to take place in April 2001 in Oxford, UK. The participants will be scientists, health workers and SME representatives from Pre-accession to EU, NIS and CEEC, ACP and ALA countries, as well as from within the EU. The objective is to confirm the international role of Community research and to promote innovation and participation of SMEs in research and development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Accelerating the transition to a toxicity pathway-based paradigm for chemical safety assessment through internationally coordinated research and technology development' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Conventional approaches to toxicity testing and risk assessment are often decades old, costly and low-throughput, and of dubious relevance to humans. These factors have prompted leading scientific bodies to call for a transition to a 21st century paradigm, including a move away from apical outcomes at high doses in whole animals, and toward a mechanistic understanding of the source-to-outcome continuum between xenobiotic exposure and adverse health effects. Such a shift will require a robust understanding of the cellular response/toxicity pathways which that can lead to adverse effects when perturbed; appropriate in vitro systems to study chemical interactions at key targets along a pathway; and computational systems biology models to describe the “circuitry” underlying each pathway as a basis for creating biologically realistic dose-response models. The AXLR8 project aims to support the transition to a toxicity pathway-based paradigm for quantitative risk assessment, and to this end will: 1) Organise a series of scientific workshops and expert meetings to map and catalogue research progress, gaps and needs in the above areas. 2) Provide a range of tools and opportunities for enhanced interdisciplinary and international communication, coordination and collaboration in order to maximise the impact of available resources. 3) Work to streamline regulatory acceptance procedures to provide for the expeditious uptake of validated 3Rs methods, including a smooth transition to 21st century systems as they become available. 4) Produce an authoritative report on the state of the science, including a practical roadmap detailing priority research and funding targets, in order to ensure a prominent role for European science in this rapidly developing global research area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Institutions and Metaphysics of Cosmology in the Epistemic Networks of Seventeenth-Century Europe' under Horizon 2020.

assistant: **Concept**

The focus of this project is the competing confessional discourses on cosmology of the seventeenth century, an epoch in which religious conflicts originated opposing ‘epistemic cultures’, which were embodied in scholarly institutions and networks such as the Protestant web of northern European universities or the global web of Jesuit colleges.In the Early Modern Period cosmological controversies (over issues such as heliocentrism, plurality of worlds, space, infinity, cometary theory, celestial matter and fluidity) were heated and amplified by increasing political and confessional fragmentation. The Roman prohibition of the Copernican system (1616) and the extraordinary condemnation of Galileo (1633) accelerated the formation of competing cosmological cultures along confessional and political lines of alliance and opposition. This research project addresses the interrelations between [1.] cosmological debates in the northern European Protestant institutional networks of scholars and institutions and [2.] cosmological debates in Jesuit institutional networks aiming at [3.] a comparative assessment of early formations and transformations of epistemic webs. It considers parallelisms and contrasts, negotiations and intersections of seventeenth-century cosmological discourses between scholars, institutions and scientific communities belonging to different epistemic cultures. This endeavor brings into focus the political-confessional dimension of early-modern cosmology and shows how science is embedded in struggles for cultural hegemony, struggles which were at once institutional and ideological. While there is a great deal of in-depth study on the history of science in various early-modern confessional contexts, a comparative study bringing together the history of knowledge