RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ground-breaking rotating biological contactor concept for small WWTP' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Wastewater treatment plants current main need is to remove nitrogen from waste water with an effective procedure and a reduced energy cost. This is of particular relevance for small size populations (accounting for up to 70 % of the market), now that the compliance with the regulation is going to be more strictly required. However, the process involved – which covers nitrification and denitrification- is highly energy demanding, implying high economic costs. Most current technologies consume large amounts of energy and the few technologies solving energetic issues (based on biodiscs) are not able to satisfactory handle denitrification phase, remaining treatment process uncompleted. In this context, ACAI DEPURACION S.L. has developed DISKIFAS, the unique solution in the global market to efficiently remove nitrogen with low energy consumption, by means of the incorporation of an anoxic reactor to the biodisc technology. This technical achievement requires an optimal adhesion of nitrifying bacteria to the biodisc, as well as the adjustment of the wastage and influent flow.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Life-Inspired Soft Matter' (Dyna-Mat) under Horizon Europe.

assistant: **Objectives**

To fulfil the quest for increasingly functional materials, biology has already offered inspiration towards advances in materials science. So far, bioinspired materials include, e.g., liquid- and dirt-repelling surfaces, structural colours, biomimetic composites, strong fibers, tissue templating, and underwater adhesives. On the other hand, stimulus-responsive, shape memory, and reconfigurable materials have been presented with switchable functional properties. They are typically in global or local energy equilibrium and their properties do not evolve or learn to allow new responses.The next challenge is to explore whether some of the characteristics considered typical for life could inspire new behaviours of artificial soft matter towards life-inspired materials.Herein I suggest three approaches: 1) Voltage controlled dynamic out-of-equilibrium dissipative mechanical properties and temperature-based switching between dynamic and static properties. 2) Light and voltage-driven self-regulation with feedback loops for adaptation, homeostasis, and oscillations. 3) Optical spiking for dynamic structural colours.The impact of this project arises from demonstrators and paradigm changing concepts for materials memory, biological learning-inspired processes, and dynamic feedback control. The underlying embodied intelligence and adaptibility pave ways to new materials concepts. In the long run, materials with such properties are foreseen, e.g., in human-device interfacing, artificial skin, prostheses, technical aids, wearables, soft robots, and medical applications.


**Keywords:** life-inspiration, adaptation, responsiveness, feedback, dissipative, out-of-equilibrium, spiking, gels
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Tissue-specific induction of autophagy as an innovative therapeutic strategy in cardiovascular and metabolic disease.'.

assistant: **Innovation**

Western-style diets are hypercaloric and characterized by high fat and high sugar content. They are responsible for an epidemic of cardiovascular disease, including atherosclerosis (AS), and metabolic disorders, including Non-Alcoholic Fatty Liver Disease (NAFLD). The European population is becoming increasingly exposed to these disorders, for which the only available therapeutic option is lifestyle modification. This typically involves dietary changes and physical activity, but patient compliance with these measures tends to be suboptimal. Pharmacological treatment options could therefore have significant potential to improve patient perspectives.With this respect, pharmacological induction of autophagy is intensively studied. Autophagy is the main detoxification and recycling mechanism of cells, and it has been shown to become dysfunctional in AS and NAFLD. Small molecules that can stimulate the process have been demonstrated to treat the diseases in animal models. However, all known autophagy-inducing molecules lack specificity, and this is suspected to cause systemic toxicity during chronic application in humans. In this proposal, we deliver molecules that avoid systemic exposure by targeting them specifically to disease-relevant tissues. First, potent autophagy inducers will be chemically linked to selected homing peptides that we hypothesize to deliver the molecules to dysfunctional vascular endothelial cells in atherosclerosis. Similarly, we hypothesize that triantennary N-acetyl galactosamine (GN3) can guide autophagy inducers to liver cells in the context of NAFLD. All molecules that are prepared in this project will be first studied in cells: both autophagy induction potential and tissue targeting will be evaluated thoroughly. For the best molecule prepared (e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Assessment of community structure and seston quality effects on plankton carbon fluxes at two contrasting coastal sites' (PCFLUCS) targeting Sixth Framework.

assistant: **Abstract**

This proposal focuses on investigating carbon fluxes within coastal pelagic ecosystems under the hypothesis that fluxes can be modulated by both community structure and seston quality. The study considers estimation of selected carbon fluxes, measurement of seston chemical composition, and determination of planktonic community structure at seasonal and sub-seasonal scales in two contrasting coastal sites: the Gullmarsfjord (Sweden, Incoming Phase of the project) and the Rio de la Plata (Uruguay, Returning Phase). The fluxes to be estimated by a combination of field observations and field/laboratory experiments include microzooplankton grazing, mesoplankton grazing on phytoplankton and predation on heterotrophs, and carbon downward export due to sinking of phytoplankton, of mesozooplankton faecal pellets, and of other biogenic structures (carcasses, marine snow, etc.).Expected results are that the planktonic community structure will modulate certain carbon fluxes at a seasonal scale, but seston quality will be most important at sub-seasonal scales. Results will contribute to the understanding of pelagic ecosystem functioning and to the development of better management practices. Furthermore, training and experience acquired during the development of this proposal will imply a transfer of knowledge with a very high potential impact for the development of this line of research in Uruguay. The development of this proposal will also contribute to the establishment of effective scientific cooperation between the European Community and the third country.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Revolutionary projector platform for virtual and augmented reality eyewear' (REALITY), addressing dissemination and exploitation.

assistant: **Impact**

Augmented reality (AR) and virtual reality (VR) technologies are finally starting to emerge from the lab into applications for everyday life. Researchers agree that the industry is only beginning its global triumph and will grow significantly in the next years – global AR/VR revenues are forecasted to hit €144 billion by 2020.The potential of AR/VR market cannot, however, be fully realised unless eyewear with an appearance of regular glasses become available. So far, it has been impossible to build proper AR/VR eyewear because of the large size and complexity of the required electronics. The biggest unsolved issue in the industry has been the imaging component which would generate excellent image quality and be small enough to enable production of AR/VR eyewear that consumers are willing to wear continuously.Finnish SME Brighterwave has created a revolutionary laser light source that is 97% smaller than its closest competitor, enabling a mass-producible ultra-compact projector engine providing the best image quality in AR/VR eyewear. We have successfully completed SME Instrument Phase 1 project NOVLASE that confirmed the technological, practical and economic feasibility of our projector engine. The REALITY project will focus on miniaturisation and productisation of the existing technology. The specific objectives of the project are:• Optimise and fabricate a laser light source and a projector engine for AR/VR eyewear;• Demonstrate the projector engine in AR and VR applications in cooperation with customers (large consumer electronics manufacturers);• Promote the technology to potential new clients to ensure commercial success.Successful completion of the project will result in the world’s smallest projector engine that enables building the first consumer-friendly AR/VR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biospheric controls on trace gas fluxes in northern wetlands' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Principal investigators: Torben R. Christensen (Sweden, Coordinator), Bo Svensson (Sweden), Pertti Martikainen (Finland), David Lloyd (UK), Richard Harding (UK), Halldor Thorgeirsson (Iceland), Henrik S0gaard (Denmark), Nicolai Panikov (Russia) We propose an interdisciplinary project investigating the biological, physical and chemical controls on trace gas exchange in northern wetlands. Special emphasis will be on the interaction between wetland plant production and methane emissions at a variety of scales. A central concept in the proposed study is to work on the interface between different scales of studying trace gas emissions in an attempt to integrate process oriented mechanistic understanding of the controls on trace gas production and consumption with landscape and larger scale modelling of ecosystem/atmosphere exchange of greenhouse gases. The approaches will be i) laboratory incubations of peat and live plant material ii) comparative field experiments along a transect of northem wetland sites with different vegetation, climate and soil conditions iii) intensive micrometeorological work at the landscape scale at an intensive study site iv) large scale ecosystem source modeling based on dynamic models developed at the landscape scale. Synthesis of data and models brought forward through this hierachy of scales will form a central new achievement of the proposed project. The project is proposed as an integral component of TERI under section 1.2.2.1 (Ecosystem functioning) in the Environment and Climate Work Programme. The project forms part of an effort to implement FATE (Feedbacks from Terrestrial Ecosystems), a Prioritised Science Plan developed under IASC (International Arctic Science Committee) and adopted jointly by the IGBP-GCTE Programme. The project builds
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterisation of a new human dna mismatch recognition' under Fourth Framework.

assistant: **Concept**

Research objectives and content The objective is to define the function of a novel human DNA mismatch recognition activity. The host laboratory has identified a heterodimeric (subunits of approximately 140kDa and llOkDa) human mismatch binding complex which appears not to be required for postreplicative mismatch repair. The llOkDa component is a member of the SMC protein family. This family also includes the S. pombe RAD 18 and E. coli RecN gene products which are involved in recombinational DNA repair and the rejoining of double-strand DNA breaks. Recently, a bovine SMC homolog has been shown to be associated with a complex that promotes DNA recombination-like activities in vitro. The size and properties of this activity resemble those of the human mismatch recognition complex. Peptide sequence obtained by mass specrometry in the host institution identified expressed sequence tags (EST) for both proteins. The clones have been obtained and will be used to isolate full length cDNAs. In vitro protein expression systems, including the yeast two hybrid system, will be used to investigate the interactions between the two component proteins of the complex and with other cellular proteins. This approach will help define the role of this mismatch recognition complex in recombination and/or DNA repair. Training content (objective, benefit and expected impact) The host laboratory has extensive experience in biochemical approaches to DNA repair, and in particular DNA mismatch repair. The candidate will obtain biochemical expertise in protein characterization and will learn how to carry out biochemical assays for DNA mismatch repair related functions. The candidate's own experience of the yeast two-hybrid system will be an essential asset in investigating the protein:protein intera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biotech venture academy coaching programme for NAS biotech companies seeking to raise investment' in the context of a Sixth Framework call.

assistant: **Objectives**

The BIO VENTURE EAST (BVE) proposal aims at raising the level of entrepreneurial management talent among young biotech companies in the New Accession States, in particular with regard to their ability to raise venture capital investment.The BIO VENTURE EAS T entrepreneur coaching programme is based on the partners' extensive experience and proven track-record in coaching European entrepreneurs on raising investment capital in the EU and the NAS. 1.1 Bio Venture East - The Strategic Goals The GOALS of the BV E programme are: -STRENGTHEN the entrepreneurial management capacity of NAS biotech entrepreneurs and management teams, with a view to increasing their capacity to grow bigger and more successful companies in the NAS, thereby resulting in greater wealth an d job creation -Improve the ability of biotech executives in the NAS to effectively negotiate with potential investors and increase their ability to raise venture capital to finance the development of the businesses -STRENGTHEN the capacity of the NAS advi sory and coaching resources available to local entrepreneurs -RAISE the visibility of Central Europe's biotech sector among the key biotech players in the EU -FACILITATE increased contact and exchange between local and West European Biotech Players, leadin g to increased business (partnering, licensing, investment, RTD co-operation etc.) 1.2 Bio Venture East - The Specific (Operational) Programme Objectives: - Design, organise and deliver a series of 5 Venture Academy Coaching Programmes - Provide powerful coaching to some 100 entrepreneurs (with at least 80% from the NAS region) at these Venture Academies - Create a Platform of 50 West and NAS Coaches - Ensure Transfer of Knowledge in a pragmatic and efficient manner to local coaches - Provide Powerful and Targe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing the economic role of the founder crops prior to the emergence of agriculture' in the context of a Horizon 2020 call.

assistant: **Objectives**

Between 10.7 and 10.2 ka cal. BP a process culminated in southwest Asia that marked the path of human history: the domestication of plants. A group of eight species including wild cereals, pulses and flax become the “founder crops” of Neolithic agriculture, revolutionizing our economy and subsistence for the time to come. But why were these species domesticated and not others? It has often been assumed that these species were staples, and the increasing need to procure more of these daily foods eventually triggered their cultivation, and domestication. However, recent archaeobotanical evidence is starting to challenge this long-held view. Building on eight of the richest and most iconic Natufian hunter-gatherer and Pre-Pottery Neolithic farming sites in SWA (14.6-10.2 ka cal. BP), this project seeks to test the hypothesis that the Neolithic “founder crops” were also staples before the emergence of agriculture. Any deviation from this view will revolutionise our understanding of the factors that triggered the process of plant domestication in SWA. To provide fresh perspectives, the work will focus on one of the most innovative, yet understudied, frontiers of archaeological research: the analyses of charred food remains (CFR). The fellow will receive training on the analyses of CFR, and pioneer an inter-disciplinary approach based on state-of-the-art archaeobotanical and biomolecular techniques, ethnobotany and experimental archaeology. In turn, she will transfer her world-class expertise in hunter-gatherer plant subsistence and archaeobotany and expand the analyses of CFR to periods and regions not previously explored by the host, as well as to foster new collaborations with academic (secondments) and non-academic partners (gastronomic faculties and haute chefs). All tog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '500 million years of ocean pH and atmospheric CO2' (CarbonDIOs).

assistant: **Innovation**

CO2 is an important greenhouse gas and building block for life. It plays a major role in regulating Earth's environment, maintaining planetary habitability, and influencing both ocean acidity and global climate. Anthropogenic carbon emissions have raised CO2 levels to their current concentration of 420 ppm, last seen 3 million years ago. Is this high? Was Pre-Industrial CO2 low? If we want to place CO2 changes in context and understand how Earth’s environment and climate will respond to changing CO2, we need to look into Earth’s geological past. My project provides a novel way to reconstruct ocean pH and atmospheric CO2 over the last 500 million years, from the dawn of complex multi-cellular life. This will permit us to quantify pH and CO2 during key periods of Earth's history, providing fundamental insights into CO2’s past and future role in driving climate, environment and life on our planet. The CO2 molecule is acidic and freely exchanges between the ocean and atmosphere, resulting in a close coupling of ocean pH and atmospheric CO2. If ocean pH is known, atmospheric CO2 can be reconstructed. Recent advances in geochemistry make it possible to constrain pH from the boron isotope composition (δ11B) of fossil shells. The principles of this pH-meter are well-understood and rooted in the laws of thermodynamics. However, to calculate pH from fossil δ11B, two parameters are needed: (i) knowledge of boron isotope composition of seawater (δ11Bsw) and (ii) organisms’ biological imprint on δ11B (‘vital effects’). Here, I propose novel approaches to reconstruct past δ11Bsw from fluid inclusions and apatite, and to calibrate vital effects on ‘living fossils’. Armed with this knowledge, and aided by advanced robotics and computation, I will create an iconic 500-million-year recor