RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Time-geographical approaches to emergence and sustainable societies'.

assistant: **Objectives**

Time-Geography is a set of analytical and modelling methods coupled with a generalising mechanism about the ways humans exploit and manipulate spatially patterned resources. TiGrESS will evaluate Time-Geographical (TG) methods as a mechanism for building the insights needed to integrate sustainability into integrated social, economic and environmental policies, and to identify key pathways towards sustainability. We will do this by means of focussed case studies In contexts of significance to sustainable socio-natural development. These include: fisheries management, urban sprawl and water demand, trans-national demographic change, sustainable agriculture and land planning.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Synergistic effect of DNA damage and oxidative stress in aging'.

assistant: **Concept**

Population aging will become one of the most dramatic challenges in public health faced by the western world in the near future. Aging affects the organism systemically even though its consequences on the brain are of particular importance because of the progressive decline of cognitive functions. Aging impacts not only individuals; it will exert profound effects on the entire society because it causes decrease in labor productivity as well as increase in health-care costs. In this regard, it is critical to develop effective treatments to ameliorate the quality of life of the elders. Ideally, successful treatments will target those early mechanisms that are responsible for initiating the molecular cascade leading to the aging phenotype. Oxidative stress – and its consequences on DNA damage - has been indicated as a major player in the process and antioxidant treatments received ample consideration. However, such treatments have been rather unsuccessful and it is still unclear whether oxidative stress really represents an initiating factor in aging. In fact, generic induction oxidative stress is not necessarily associated to an aging phenotype. On the contrary, genetic disruption of some DNA repair mechanisms accurately mimics this physiological process. The goal of this grant is to provide insights about the causative mechanisms of aging in the brain and to generate information useful to develop effective antioxidant therapies. For this purpose, we will use genetic mice models of aging – where the DNA repair machinery is impaired – to understand if oxidative stress is causative of DNA damage or vice versa. To discover new biomarkers, studies on mitochondrial physiology will be paralleled by analyses of protein oxidation to understand which proteins specifically undergo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrating the Physical with the Digital World of the Network of the Future' (SENSEI).

assistant: **Concept**

In order to realise the vision of Ambient Intelligence in a future network and service environment, heterogeneous wireless sensor and actuator networks (WS&AN) have to be integrated into a common framework of global scale and made available to services and applications via universal service interfaces. SENSEI creates an open, business driven architecture that fundamentally addresses the scalability problems for a large number of globally distributed WS&A devices. It provides necessary network and information management services to enable reliable and accurate context information retrieval and interaction with the physical environment. By adding mechanisms for accounting, security, privacy and trust it enables an open and secure market space for context-awareness and real world interaction.<br/><br/>Tangible results of the SENSEI project are: 1) A highly scalable architectural framework with corresponding protocol solutions that enable easy plug and play integration of a large number of globally distributed WS&AN into a global system -providing support for network and information management, security, privacy and trust and accounting. 2) An open service interface and corresponding semantic specification to unify the access to context information and actuation services offered by the system for services and applications. 3) Efficient WS&AN island solutions consisting of a set of cross-optimised and energy aware protocol stacks including an ultra low power multi-mode transceiver targeting 5nJ/bit. 4) Pan European test platform, enabling large scale experimental evaluation of the SENSEI results and execution of field trials - providing a tool for long term evaluation of WS&AN integration into the Future Internet.<br/><br/>Technology developed by SENSEI will play an essentia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Role of the fyn molecular complex in human t cell activation and t lymphocyte diseases' (1994-1998).

assistant: **Innovation**

p59fYn represents one of the protein tyrosine kinase expressed in T lymphocytes whose precise function during T cell activation is poorly understood. To gain insight into the mechanisms by which Fyn is involved in T cell signaling, we propose to purify and clone phosphoproteins that interact with the kinase through its SH2 domain. Subsequently, we will investigate whether the Fyn complex undergoes modifications during T cell activation. Additionally, in order to further assess the critical role of Fyn and its associated proteins, we will also analyze the Fyn complex under pathophysiological conditions, e.g. in T lymphocytes isolated from leukemic patients. The realization of this project could contribute to better understanding the role of Fyn in T cell signaling as well as the mechanisms involved in the developement of T cell lymphomas or leukemias.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability will be assessed as to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of PAH pollution. We will generate a knowledge base not only on the microbial catabolome for biodegradation of PAHs in various impacted environmental settings based on genome gazing, retrieval and characterization of specific enzymes but also on systems related bioavailability of contaminant mixtures. MAGICPAH takes into account the tremendous undiscovered metagenomic resources by the direct retrieval from genome/metagenome libraries and consequent characterization of enzymes through activity screens. These screens will include a high-end functional small-molecule fluorescence screening platform and will allow us to directly access novel metabolic reactions followed by their rational exploitation for biocatalysis and the re-construction of biodegradation networks. Results from (meta-) genomic approaches will be correlated with microbial in situ activity assessments, specifically dedicated to identifying key players and key reactions involved in anaerobic PAH metabolism. Key processes for PAH metabolism particularly in marine and composting environments and the kinetics of aerobic degradation of PAH under different conditions of bioavailability will be assessed in model systems, the rational manipulation of which will allow us to deduce correlations between
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Recombinant vaccines for fish disease' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

In 1993, the global aquaculture industry produced 23% of the world's food fish at an estimated market value of 40 billion euros. As the world population increases and oceanic fish stocks dwindle the gap between supply and demand must be filled by aquaculture, and yet up to half of all farmed fish succumb to infectious disease. Induction of immunity is the best strategy for protecting farmed fish against disease, but effective vaccines are not yet available against most of the important viral pathogens. The applicants have already developed the first effective recombinant subunit vaccine for aquaculture. An Exploratory Award is sought to fund preparation of a CRAFT scheme application and the assembly of a consortium of partners who will develop subunit vaccines against fish pathogens with the greatest impact on the European Industry. The proposed research will result in improved disease control in aquaculture, resulting in increased productivity and profitability within the industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Acorai Heart Monitor - Non-invasive multi-sensor device for heart failure monitoring' under Horizon Europe.

assistant: **Concept**

Heart Failure is a progressive clinical syndrome with multiple etiologies. It is associated with nearly three million hospitalizations in the EU annually, representing 30% of all readmissions, and accounts for up to 5% of the entire healthcare expenditure. Despite modern medical treatment, HF is a life-threatening and debilitating condition with a poor prognosis.  The Acorai Heart Monitor (AHM) is a monitoring device designed to detect and estimate hemodynamic parameters non-invasively. AHM is a handheld electronic device that features multiple sensors to collect data from 4 sensor types based upon patented the SAVE sensor system to estimate the absolute pressure of the heart failure patient's cardiac system. The sensor data are processed within the medical device with machine learning (ML) methods, the results are then displayed to be read by a qualified healthcare professional (HCP).Delivering Intracardiac pressure to HCPs to guide the treatment of patients with HF leads to improved quality of life. It lowers the frequency of hospital admissions, yet all current tools require an invasive procedure. AHM is a multi-patient non-invasive device that would dramatically disrupt the paradigm of HF treatment and lead to significant cost saving in the EU whilst improving the overall prognosis of patients who suffers from HF. With the growing prevalence of HF globally the AHM is a tool with applicability in multiple workflows and represents a first-of-its-kind device to revolutionise HF management.AHM has already been validated in 300 patients in a Swedish proof of concept study and now needs the support to bring this device to market and collect data via a large multi-national study to prove its effectiveness. The AHM is fully patent protected with three granted patent familie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'unraveling nucleate BOILing: MODEling, mesoscale simulatiONs and experiments' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cooling efficiency is of the upmost importance in several crucial technological applications, e.g. fuel cells and battery cooling, hybrid airplanes, drones and satellite thermal management. They have a value of several billions dollars around the world, with a critical contribution to global CO2 production. A promising approach to cope with the always higher heat fluxes requested is represented by phase changing systems which exploit the large latent heat associated with phase change to remove the heat from the hot surface. A robust and effective strategy is to deploy boiling. The basic underlying idea is simple: form vapour bubbles in a liquid in contact with the hot surface and evacuate them through a condenser. Its implementation, however, faces a number of challenges and requires solution to several fundamental problems. In any practical application the boiler efficiency depends on parameters, such as the frequency of bubble nucleation, their size, and the release rate from the hot surface. However, how to precisely control them is still not clear. BOIL-MODE-ON aims at addressing the underlying mechanism of bubble inception and departure during boiling, defining possible new routes and solutions both on the modelling and the practical implementation side. Dr. Magaletti will apply a cutting-edge methodology he developed in the context of cavitation phenomena, based on a mesoscale numerical modelling of the liquid-vapour system embedding thermal fluctuations. It will shed light on the effects of surface wettability and dissolved gas, which are two of the most complex and not yet understood topics in this field. A specific campaign of experiments will complement and support the analysis. The recognised experience of Prof. Marengo, who will supervise this project, on th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Matter at high density and properties of neutron stars' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

1) Superfluidity in inhomogeneous hadronic systems. Free neutrons are ex- pected to be superfluid at most of the temperatures and densities typical of a neutron star. Pairing gaps of superfluid neutrons in the crust of the star, expected at densities below 10ll g cm-3 are important parameters for calculations of the dynamics of the star (e.g., pulsar glitches and cooling times). In particular in the calculations of neutron matter one simply considers the system as infinite and homogeneous. However, neutrons move in a very inhomogeneous background due to the presence of nuclei. At first sight, one shouldn't expect Dig differences between the homogeneous and the inhomogeneous system, because in a superconductor the addition of impurities in the lattice doesn't alter the pairing prop- erties of the system (what is referred to as Anderson's theorem"). on the other hand, for the superfluid of neutrons inside the crust of a neutron star the coherence length is compa- rable to the typical size of density variations induced by nuclei and thus variations respect to the inhomogeneous case are expected. This problem is encountered also in solid state physics at a different scale, since the sizes of the normal metal and of the superconductor are macroscopic. In previous works, we have used a semiclassical model of superfluidity consisting of a local solution of the BCS equations of superconductivity [2,4,11,19,22]. It was found that the inhomogeneities may account for most of the specific heat in the crust of a neutron star, a parameter of interest for cooling calculations. However the semiclassical approximation can fail in the cases where the coherence length of the superfluid is much larger than the nuclei. This is what happens in most of the crust and expecially at high densiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Storage capacity sharing over virtual neighbourhoods of energy ecosystems' (SHAR-Q) under Horizon 2020.

assistant: **Objectives**

Storages are unavoidable components of the future smart grid with large share of variable renewable generation. However, the unit-cost of energy, that is retrieved from storages, is several times higher than the cost of energy consumed upon its output from RES. Therefore, there is a strong requirement on the optimisation of storage capacities deployed in the grid. This is especially true for the small energy sites such as DER and prosumers’ microgrids which are the segments, targeted by the SHAR-Q bottom-up concept.  The principal objective of the SHAR-Q is to optimize the storage capacities deployed in the grid with the help of a peer-to-peer interoperability network that connects neighbourhooding RES+Storage ecosystems into a collaboration framework. Thus, the optimization of storage capacities can be achieved through their sharing among the participating actors. To get connected to the SHAR-Q network, an open interoperability gateway with semantic interface descriptors will be provided that will be based on the most adopted standards in the field. Moreover, the users will be provided with an ability to manage their contribution to the collaborative models on their own in a way that resembles the well-known social web portals (e.g. users can control with whom they wish to share specific storage capacities). The viability of the collaborative business models will be proven through added-value services, deployed over the SHAR-Q interoperability network, that will be demonstrated in 3 different pilots, targeting 3 different segments of end-users such as neighborhoods of distributed RES, coalitions of prosumers and locations with e-vehicle charging stations. The SHAR-Q research and innovation activities will be driven by the opinion of stakeholders involved in the SHAR-Q
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MYRRHA Accelerator eXperiment, research and development programme', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The present FP-7 proposal MAX is subsequent to the recommendations of the Strategic Research Agenda of SNETP for ADS development in Europe. Its aim is to pursue the R&D required for a high power proton accelerator as specified by the MYRRHA project. There is especially a strong focus on all the aspects that pertain to the reliability and availability of this accelerator.This R&D effort builds on the large body of results and the clear conclusions that have been obtained during the consecutive FP5 project PDS-XADS and FP6 project EUROTRANS. MAX will further investigate the key issues of redundancy and fault-tolerance by real-world experience in making maximum use of already existing or to-be-built dedicated prototypes, both on the injector side and on the main superconducting linac side.At the end of the MAX project, it will be possible to generate an updated consolidated reference layout of the accelerator for MYRRHA with sufficient detail and adequate level of confidence in order to initiate its engineering design and subsequent construction phase.