RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The development of a predictive biomarker for immunotherapy outcome based on flow cytometry test' under Horizon Europe.

assistant: **Concept**

Immunotherapy has revolutionised clinical oncology, with the use of immune checkpoint inhibitors (ICIs). These agents are in clinical use for almost a decade, treating over 20 types of cancers. They have shown a remarkable therapeutic benefit even in patients with advanced disease. Yet, only a small proportion of patients benefit from this therapy, leaving the rest resistant, for reasons that are still not clear. While there are certain clinical biomarkers to predict ICI therapy outcome, their prevalence and prediction power is rather limited. Therefore, there is a clinical unmet need to develop more powerful biomarkers to predict response to immunotherapy. In our ongoing ERC consolidator grant we discovered a unique sub-population of neutrophils, present in peripheral blood, that predicts response to immunotherapy in a very high probability. We designated these cells as immunotherapy-responsiveness cells (IRCs). Using various mouse models, we demonstrate that the levels of circulating IRCs measured at baseline are significantly higher in responding tumours to ICI therapy. These results were confirmed in a limited number of non-small cell lung cancer (NSCLC) and melanoma patients. Hence, our aim is to further test IRC levels in clinical samples, to evaluate their predictive power for ICI therapy, and to develop a clinical liquid biopsy-based predictive biomarker using flow cytometry test. The development of clinical IRC detection based on flow cytometry (BioFlow®) can serve two markets: (1) Clinicians – enabling oncologists to easily predict response to ICI therapy, thus improving personalised immunotherapy treatment; and (2) Pharmaceutical companies - developing immunotherapies - that can use IRC detection in development stages and through clinical studies, enabling ti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Protein folding, misfolding aggregation and disease'.

assistant: **Objectives**

In 1996 researchers in Oxford, Groningen, EMBL, Rome and Granada together established a TMR network to address fundamental aspects of protein folding. This proved highly successful and lead to several significant scientific advances. This application is to fund the expansion of the network into the 5th framework. The goals are :i) to build on the achievements of the previous network;ii) to continue the progress in understanding the mechanism of protein folding and iii) to exploit our collective expertise to tackle the developing question of protein misfolding and disease. Specifically, the aim of the new network is to understand how interactions between amino acid residues lead to the kinetic and thermodynamic control of protein folding in order to develop the ability to predict which peptide sequences will fold a unique structure, which will not, and which may form toxic high order aggregates such as amyloid fibrils.Objectives include:1. To understand in detail the mechanisms of the folding of several small proteins, with particular emphasis on the relationship between folding kinetics, folding mechanism and structure.2. To explore the evolutionary basis of naturally occurring protein sequences in terms of their folding behavior, with emphasis on the importance of the avoidance of aggregation and fibril formation.3. To structurally characterize folding intermediates and explore the relationship between folding intermediates and species involved in initiating aggregation in peptides or proteins. To achieve these objectives the network will use a coordinated approach combining biophysical , protein engineering and computational techniques that is the strength of the Folding Network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optical proximity techniques in microelectronics applications' under Fourth Framework.

assistant: **Concept**

The overall goal of OPTIMA is to demonstrate the effectiveness of proximity corrections in a production environment for both memory and logic applications.To develop a commercially available software tool which generates fully automatically a proximity corrected IC design with maximum CD variation due to proximity effects not more than 5% of the target dimension.To produce test masks for proximity parametrisation, demonstration masks for logic and memory applications (total dimension control better than 70 nm), and masks to investigate the resolution limits when applying OPC in combination with other enhancement techniques (total dimension control better than 50 nm).To assess the economical impact of the introduction of OPC taking into account that prices of proximity corrected reticles will be close to those of embedded PSM.Optical lithography is a key technique used in semiconductor manufacturing. Strong efforts are being made worldwide to drive it to its technical limits in order to postpone the inevitable introduction of non-optical techniques. Optical Proximity Correction (OPC) is a novel technique which will make it possible to extend the practical resolution limits of existing exposure tools by at least one technology generation. The necessary OPC tools will be developed and evaluated under OPTIMA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Analysis of the oxidative modifications on casein micelles exposed to different oxidative sources: determining the impact of these modifications at a structural and nutritional level' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Oxidative damage is a major problem for dairy industry as it can occur to a significant extent during the processing and/orstorage of milk, and results in significant wastage. Due the high abundance of proteins, ~30% of the dry mass of whole milk,these represent one of the most abundant targets of damage. Protein oxidation can have a direct impact on the nutritionalvalue of milk and the consumption of highly oxidised proteins may have deleterious consequences for human health. Thisproject will provide an improved understanding of the degradation pathways of the most abundant milk proteins (caseins),the micelle structures that these proteins form, and the key drivers of these reactions. To address these aims, this projectwill: (1) investigate the oxidation of casein micelle (CM) mediated by the most relevant oxidative sources generated duringmilk processing and storage, and (2) determine the consequences of CM oxidation on their nutritional value (i.e. loss ofparent amino acids) and the biological effects (i.e. decreased digestibility, toxicity to human cells). The approaches to beused in this project include analytical, biochemical and biological techniques (i.e. liquid chromatography, SDS-PAGE,western blotting, mass spectrometry, electron microscopy, cell culture models). The project is of interest to the Europeancommunity as milk and dairy products represent one of the most consumed food materials, with health and nutrition claimsfor these products based on the presence of specific materials, such as proteins. It is therefore critically important that theseclaims are justified and correct. This project will provide important new knowledge, as there are currently no data availableas to the pathways responsible for CM oxidative modifications. Such data is a pre-requisit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Electro-Magnetic Microbead Technology for Biosensor Application'.

assistant: **Objectives**

A new base technology for extremely sensitive electromagnetic integrated sensors for the on-chip detection of analytes such as antibodies or DNA as well as for a simple multiple determination of binding forces is developed. Microbead labelled analytes are specifically captured by e.g. antibody-antigen interaction at microelectrodes. The detection of analytes is based on the strong impact of the labels on a space-dependent electrochemical current generated by microelectrodes. This current is switched from high level to low level when the microbeads are captured and is switched back when the microbeads are removed by magnetic forces. The proposed technology will have the potential to stimulate the development of a new generation of smart analytical sensor devices with extremely low detection limits and allow an alternative way to monitor relevant substances without consumption of critical additional solutions and reagents.OBJECTIVESThe objectives of the experimental assessment project are:1) Reduce the technical risk associated with the uncertainty about the proposed measuring principle with regard to the qualitative and quantitative detection of a biochemical reaction.2) Reduce to an acceptable level the technical risk associated with the uncertainty about the IC compatible technological processes pertinent with the manufacturing of the novel sensors. DESCRIPTION OF WORKUOB (U.K.) is responsible for the development and manufacture of the transducers. These transducers with dimensions of only few square millimetres will bear an array of 100 platinum microelectrodes most of which can be separately addressed. Each single electrode will be surrounded by a micro-coil for the generation of controlled magnetic forces acting on the particles. Especially the electrode array mater
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Noradrenergic control of human cognition'.

assistant: **Innovation**

The locus coeruleus (LC) is the brainstem neuromodulatory nucleus responsible for most of the norepinephrine (NE) released in the brain. The LC has widespread projections throughout the forebrain. Indeed, this small nucleus innervates a greater variety of brain areas than any other single nucleus yet described. It is clear that the neuromodulatory effects of NE must have pervasive influences on cognitive function in humans. However, these influences are poorly understood, in part because of the challenge of linking disparate levels of description: low-level neuromodulatory effects and mental computations. Furthermore, recent theories about LC function are almost exclusively based on animal studies and computational modeling. In contrast, there have been very few empirical studies of LC-NE function in humans. This is not so surprising since the study of this system in humans poses considerable methodological challenges.The major aim of the proposed research program is to enhance our understanding of the role of the LC-NE system in human cognition through the use of two cutting-edge methods: First, I intend to directly measure BOLD responses in the LC using a set of newly developed MRI methods for brainstem imaging. Second, I propose a number of psychopharmacological studies to directly manipulate LC-NE function and measure the corresponding effects on brain and behavior. These methods will allow me to address a wide range of questions—many of which have not been addressed in animal models—concerning the role of the LC-NE system in optimizing task performance in the context of uncertainty about the environment, performance errors, emotional  stimuli, and other demanding situations. The proposed research will be critical in elucidating the role of LC-NE function in human a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced Testing Methods for Better Real Life Performance of Biomass Room Heating Appliances' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Existing test standards for biomass room heating appliances (pellet and firewood stoves, and inset appliances) have supported technology development tremendously in past decades. Due to today’s changing and more demanding requirements, however, there is the obvious need for refined testing procedures in order to differentiate between poor and excellent products. Such differentiation should take into account operating conditions as they are found in real life installations. Offering such information to customers will create substantial competitive advantages to innovative SMEs providing high quality products and may provide a reliable guideline for future standards or regulations.The key objectives of BeReal are- Development of advanced testing methods for room biomass heating appliances to better reflect real life operation- Development of a centralized standard evaluation tool for quality assurance purposes- Validation of methods at an early stage of development- Proof of real life impact of advanced products by field test demonstration- Proof of reliability and reproducibility of testing methods and evaluation tools through a Round Robin test- Development and introduction of a quality label based on the novel testing methodsThese are accompanied by dissemination activities addressing standardization bodies, SME-members of participating SME-AGs and notified bodies, including training activities for the latter two groups. The introduction of the quality label addresses end users and general public.The consortium consists of 2 national and 1 European SME-AG, 7 OTHER participants (3 SME stove manufacturers, 1 SME component supplier, 1 SME certification supplier, 2 large industry stove manufacturers) and 5 RTDs of high international reputation. SME-AGs will be supported by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Joint European Research Infrastructure of Coastal Observatories - Design Study' in the context of a Horizon 2020 call.

assistant: **Objectives**

Exerted pressures on the ocean and more particularly on the coastal and shelf seas increasingly disturb increasingly disturb coastal regions and ecosystems, and will strongly impact our future. To improve the understanding of underlying processes, the series of EU-funded JERICO (Joint European Research Infrastructure of Coastal Observatories) projects have consisted, since 2007, in continuously improving observations in European coastal marine areas where most of the world population lives, with the objective to build a pan-European Research Infrastructure (RI) providing high-quality marine data, expertise, services, facilities and observation systems. The data produced in this long-term framework are multidisciplinary, standardized, quality-controlled, sustained, interoperable, and free for access and use. However, to better serve the scientific community and address societal and policy needs, JERICO has to progress towards a structured operational European RI supported by the EU Member States (and associated members) and the EC, and endorsed as a high-value RI at EU level as part of the ESFRI roadmap. JERICO-DS will thus analyze the needs and propose a design for a state-of-the-art, fit-for-purpose, visionary and sustainable observational European RI providing expertise and high-quality data on European coastal and shelf seas, supporting world-class research, high-impact innovation, and visibility of European excellence worldwide. JERICO-DS will conceptually design the entire picture of the JERICO RI, covering both hardware and software components, and including cutting edge technologies from the sensor level to the information and service distribution to users, hence contributing to the Smart Ocean. JERICO-DS will build on nations’ will and involvement to co-construc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploring factors determining resilience to marine heatwaves in coastal temperate rocky habitats' in the context of a Horizon Europe call.

assistant: **Objectives**

Coastal ecosystems, vital for global biodiversity and human well-being, face growing threats from climate change (CC), particularly marine heatwaves (MHWs), which are causing irreversible ecological changes. As a result, the enhancement of ecosystem resilience to disturbances has become a critical research and socio-political priority. Although there is substantial documentation of MHW-induced mass mortalities and thermal tolerance thresholds of key species, multifactorial mechanisms that help marine species and coastal ecosystems to resist and recover from MHWs are not well understood. RES2HEAT aims to fill this gap through a comparative, multidisciplinary approach, studying two contrasting Mediterranean habitats. We will investigate how various factors acting at different ecological levels affect the resilience, including both resistance and recovery capacity, of coastal ecosystems to MHWs. Specific objectives are: (1) evaluate differential resilience of communities and species to MHWs by analysing long-term changes in community and habitat complexity and developing a new index to quantify habitat complexity; (2) explore plasticity and heritable components of phenotypic variation of key species in response to thermal stress through common-garden and reciprocal transplant experiments with populations from varying thermal histories; and (3) characterize the genetic structure and connectivity among and within populations of key species to understand their ecology, including local dispersal, reproductive biology, and gene pool stability, using next-generation sequencing and demo-genetic methods. RES2HEAT integrates innovative and traditional methods, including long-term and regional data series, experiments, demographic sampling, novel underwater photogrammetry techniques
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Preparatory Phase of the IRUVX-FEL Consortium' in the context of a Seventh Framework call.

assistant: **Objectives**

The successful demonstration of single-pass free electron lasers (FEL) around the year 2000 triggered a number of research centres in Europe, the United States and Asia to initiate the construction of new research infrastructures. These projects are based on strong science cases put forward by interested research communities. The new FEL sources combine the wide and continuously tunable wavelength range of synchrotron radiation with ultra-short pulses and coherence of lasers, but at much higher peak and average power, offering completely new research opportunities in different areas of science for a large research community. Several European countries are supporting the construction of national FEL facilities which are now combining their forces and coordinating their activities to build and operate a distributed European facility, the IRUVX-FEL. This facility will be able to offer a suite of complementary sources and instrumentation that is unsurpassed in the world. The main objective of the IRUVX-FEL Preparatory Phase is the integration of the national FEL facilities into a distributed European FEL facility in order to fully exploit the complementary features and expertise of the individual member facilities and to maximise the benefits for both the member facilities and the users. This includes the agreement and implementation of structures and methods that allow efficient construction and operation of the IRUVX-FEL facility, and the preparation of critical technology ensuring that all member facilities will be exploited with highest efficiency. The access to this world-class facility will be facilitated by transparent and coordinated access policies and procedures agreed by the IRUVX-FEL consortium. The present proposal includes all the necessary preparatory work to