RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'On-Antenna Multi-Analyte Biochemical Sensing (ASense)'.

assistant: **Objectives**

Lab-on-chip (LOC) devices are useful for manipulating, analyzing, and interacting with small samples in a wide range of applications. Wireless LOC devices have been developed for remote and distributed analysis purposes where wired measurements are not feasible or cost-effective. The devices consist of a miniaturized array of biochemical sensors connected to a low-power radio transceiver. The current trend in wireless LOC devices is to miniaturize the sizes, lower the power consumption, and increase the processor capacity while driving down costs which are rapidly approaching their practical and theoretical limits. These raise the need for a new design to support the future sustainability of these devices to facilitate the current and upcoming massive deployments for use in various applications. Triggered by this, the project explores the revolutionary secondary use of the wireless antenna for multi-analyte active sensing purposes by deploying case-tailored sensing nanomaterials on the antenna surfaces current spots with each targeting a specific analyte using a Molecular Imprinting Polymer (MIP) layer grown above a highly conductive 2D transduction nanomaterial layer. The idea is to move the complexity from the wireless LOC to the computation of the gateway station, where signal processing and machine learning techniques are employed to remotely sense the targeted analytes. This is done by detecting changes on the radiation characteristics of the antenna caused by the applied sensing materials. The idea of using the antenna as a multi-analyte active sensor is an absolute novelty. If successful, the approach will have a huge contribution in reducing the hardware complexity of standard wireless LOC devices by at least 50% (no need to sensor integrated circuits, microcont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Enabling advanced functionalities of Diamond and other ultra-hard materials by Integrated Pulsed Laser Ablation Technologies' (DIPLAT) under Seventh Framework.

assistant: **Objectives**

Diamond and other ultra-hard materials possess outstanding mechanical, wear and thermal properties that make them attractive to manufacture a wide range of high value-added products such as high-performance, smart tools. However, due to the extreme properties of this group of materials, efficient and precise generation of complex 3D freeform geometries and structures to meet the needs for a further development of high-performance tools is still a challenge. DIPLAT addresses the need for an efficient, precise and flexible processing technology for ultra-hard materials in tooling applications, in order to fully exploit the potential of these materials. By smartly utilizing the advantages of high brilliance short and ultra-short pulsed lasers, a tooling technology based on 3D Pulsed Laser Ablation (PLA) will be developed and demonstrated for various industrial applications. DIPLAT will introduce new technology platform for producing ultra-hard tools with enhanced functionality, outstanding machining performance and superior lift-time. In this regard, DIPLAT fosters the following four main scientific and technological objectives: (1) Design functional surfaces (with controlled micro geometries) on diamond and other ultra-hard materials to enable enhanced functionality for tooling applications; (2) Study and development of advanced 3D processing strategies for structuring/conditioning of ultra-hard tool surfaces and superabrasive grain layers by Pulsed Laser Ablation; (3) Develop and implement a novel multi-axis control concept and a model-based CAM software support module to enable optimized 3D pulsed laser processing; (4) Fabrication of various novel prototype tools made of ultra-hard materials and demonstration of their superior performance and functionality in challengin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Facilitating regional learning processes in a competitive environment: regional socio-economic and cultural development in three accession countries and three member states.' to be submitted under Fifth Framework.

assistant: **Abstract**

This thematic network proposal wants to stimulate regional learning processes using the structural indicators" benchmarking methodology. The network intents to explore the parameters of a regional learning dynamic that is encompassing in two senses :(1) in promoting "support-led" (A. Seen) regional growth and(2) in promoting the European integration of accession countries. Two levels of networking will be addressed : the scientific community and the regional social actors. An interactive website "European Learning Region Platform" will be created to assure the sustainability of the networking capacities build up during the three years of the project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantum Information Transduction with Acoustic Resonators' under Horizon 2020.

assistant: **Concept**

Modern telecommunications networks make use of light in optical fibers to connect devices where information is processed in electronic circuits. Such an architecture can also be used to communicate and process quantum information. Local quantum processors based on superconducting (SC) microwave circuits are now capable of performing sophisticated tasks ranging from quantum simulation to quantum error correction. At the same time, low-loss quantum channels based on infrared (IR) light can transfer quantum information over long distances.  However, the crucial link between these two systems that would allow for the realization of a quantum network is still missing. Since quantum states are much more fragile than classical signals, quantum transduction between the electrical and optical domains must be highly efficient without introducing new sources of decoherence that interfere with the operation of the local processors or long-distance channels. The goal of this project is to create a quantum transducer between SC circuits and IR light using a third quantum system: sound waves in an acoustic resonator. My recent work showed that these mechanical resonators possess properties that make them highly promising for implementing a quantum transducer. They couple efficiently to both SC circuits and IR light, and can be used to store and manipulate quantum states of sound. The project will combine electromechanical and optomechanical transduction, which so far has only been implemented separately, in a single system. By developing techniques for integrating optics, acoustics, and microwave circuits at cryogenic temperatures, I will demonstrate the conversion of complex quantum states between the microwave and IR domains and use this capability to entangle remote SC quantum node
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Gaining insights into human evolution and disease prevention from adaptive natural selection driven by lethal epidemics' (SELECTIONDRIVEN) under Horizon 2020.

assistant: **Objectives**

Background Lethal epidemics like the Black Death have killed millions of people and must pose an extreme selective pressure on any genetic variant that confers disease protection. Therefore, such epidemics have been hypothesized to play a key role in the evolution of humans. To what extent this is true, is a fundamental question of wide interest. Yet, it remains unanswered, in part due to limitations of the current methods to detect signatures of selection.Objectives I wish to accomplish three linked goals with the proposed project. The first goal is to develop new statistical methods for detecting signatures of adaptive natural selection driven by lethal epidemics. The second goal is to use these new methods to investigate the role of epidemics in recent human evolution by applying them to genetic data from several recent epidemics. The third goal is to gain insights into mechanisms that protect against infectious disease via the identification of genetic variants that have been under selection because they confer disease protection.Methods To reach these goals, extensive simulations will be performed to carefully characterize the genetic signatures of adaptive selection acting on a protective genetic variant during an epidemic. Then new statistical methods that can detect these signatures will be developed. Next, the new methods will be applied to several real datasets, including one from a recent Ebola epidemic. Finally, all signatures of selection detected in these real datasets will be further investigated.Expected outcome and importance This project will deliver new statistical methods that will move the field of selection studies a substantial step beyond the state-of-the-art by filling an important methodological gap. It will also yield key insights into the rol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deoxyuridine triphosphatases (DUTPases) as targets for treatment of infectious diseases and cancer' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

- To explore the potential of the enzyme dUTPase (deoxyuridine triphosphatases) as a target for the development of compounds active against viruses, protozoan parasites (Leishmania, Trypanosoma) and bacteria, and against human neoplastic diseases. - To investigate dUTPases from the various sources and mutational variants of those with respect to catalytic properties and inhibition with substrate analogues. - To determine three-dimensional structures of the dUTPases and complexes of structurally determined dUTPases with inhibitory substrate analogues. - To synthesize and test candidate compounds in rational drug design towards dUTPase inhibitors specifically active against pathogen targets and tumor cells by using enzyme measurements and cell-based assays.The enzyme dUTPase acts in all classes of dividing cells, and also in certain virus infected cells, to minimise levels of deoxyuridine triphosphate (dUTP). If not removed, dUTP is incorporated into DNA. Inhibition of dUTPase both interrupts supply of thymidine triphosphate (dTTP) for synthesis of DNA and also causes damage to nascent DNA, and so can lead to cell death. dUTPases from different sources show a range of structural and enzymic properties, indicating that it should be feasible to find inhibitory compounds that act differently on the dUTPase of pathogens rather than on the enzyme of the host. dUTPase therefore constitutes an attractive potential target for therapeutic intervention against many infectious agents, and a dUTPase inhibitor might also be suitable for differential action against proliferating human neoplasms. The proposal sets out plans to advance basic understanding of the dUTPases, and to utilise this information to discover inhibitory substrate analogues. X-ray crystallographic groups in the part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development and construction of a lightweight chassisless semi-trailer' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Road transport is by far the most important form of transport for goods in the EC and is expected to grow by 25% within the next 15 years. This growth is in conflict with the environmental awareness within the EC. Therefore a number of innovations are needed in the road transport business. Amongst the development of more fuel efficient and cleaner engines for trucks, also new innovations in the present semi-trailers are needed to lower the pollution by road transport. This project aims at the development and construction of a new lightweight multi-functional semi-trailer that meets the transport demands for the future: high pay-load and high utilization. The realization of these demands will not only lead to an improved competitiveness of the European transport business but will also lead to environmental benefits since less rides are needed for the same amount of freight. Innovations in the present semi-trailer concept that can serve this task are:  A reduction of the nett tar weight  An increase of the inner volume  The introduction of multi-functionality The fulfilment of these objectives requires the introduction of innovative integrated design methodologies (e.g. CAD/CAM and CAE) and novel manufacturing concepts. The global approach of this cooperative research project is therefore to make use of materials and processes that allow for the integration of system and structural functions. At this moment most of today's semi-trailers are based on a heavy steel chassis on which an (insulated) box is mounted. Recently also chassisless concepts based on a aluminium beam structures have emerged (see front page photograph), which resulted in a reduction of weight but at the expense of assembling costs. The aim of this research is to replace these two (heavy / labour intensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Breaking the barrier: How inflammation spreads from skin to joint', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Physical barriers of the body and their immunological dysregulation are connected to a variety of inflammatory diseases and therefore an emerging area of interest in medicine. The gut and its microbiome gained center stage, whereas the skin as large primary immunological barrier to the environment is still less appreciated. Psoriatic arthritis (PsA) is a prototypic inflammatory disease which usually starts with skin lesions, before spreading to the musculoskeletal regions. To date, it is still obscure why the inflammatory process in some patients with psoriasis is restrained to the skin, whereas in other patients it extends to tendons and joints. Moreover, disease spreading to the joints associates with local tissue remodelling as evidenced by new bone formation at the insertion site of tendons into the bones. The molecular and cellular regulation of this “skin-joint axis” leading to development of PsA is still unclear but essential to understand organ communication in inflammatory diseases, the identification of potential biomarkers for early recognition of the disease and the development of preventive treatments. We will take advantage of a new model resembling PsA, which was established in our lab, with the aim of (1) studying disease spreading from the skin to musculoskeletal regions, (2) deciphering the molecular mechanisms that lead to uncontrolled local tissue remodeling, and finally (3) testing a new translational approach to prevent spreading of inflammation and tissue remodelling. We plan to adopt cutting-edge techniques to achieve our goals, which in turn will contribute to a better knowledge of the connection between epithelial surfaces and inflammation.


**Keywords:** Spreading of inflammation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Characterization of NK cell distributions and functions in human tissues in HIV-1 pathogenesis'.

assistant: **Concept**

HIV is an urgent global health problem and a safe and effective vaccine is desperately required. Although many studies have shown that the innate immune system, and in particular, natural killer (NK) cells play a central role in determining the quality of the host immune response to HIV -1, the full host beneficial potential of the anti-HIV-1 NK-mediated activity can not be realized in vivo, as NK cells function becomes compromised in a majority of HIV-1 infected individuals. Several previous experience with HIV-1 infected patients, indicate the significant changes in the redistribution of NK cell subset in the peripheral circulation towards the dysfunctional subpopulation of NK cell. It is likely that the redistribution of NK cell towards this aberrant population may contribute to the observed lack of NK cell function over the course of HIV-1 infection. However, changes in NK cell subset distributions and in effector functions in different anatomical sites and tissues, in healthy donors and in HIV-1 patients, at different stages of HIV-1 infection have been poorly characterized and require further investigation. Given that NK cell are found in female reproductive and in gastrointestinal tracts and that these mucosal layers can play critical roles in the course of HIV-1 infection: as the site of the HIV-1 invasion, as the mother-to-child transmission site, and as the reservoir and important source of virus in HIV-1 infected patients, we propose a multidisciplinary “translational research” project that will exploit: (i) the correlation between tissue-specific distribution of NK cell subpopulation(s) and different stages of HIV-1 infection, (ii) the source of functional and molecular dysfunctions of tissue-specific NK cell subpopulation(s) and their relevance in HIV-1 pat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Minimally invasive endoscopes for neuronal activity monImaging-assisted single-cell specific activity monitoring and optogenetic stimulation of deep brain structures in motile and awaken animal models'.

assistant: **Innovation**

Severe neuronal disorders such as dementia affect more than 1 billion people globally and account for economic burden far exceeding that of cancer. Our only chance of treating dementia is improving our understanding of how brains function at diverse levels of complexity. This will only be possible through better technologies, which already reflects in synchronised actions worldwide, such as the US Brain Initiative and EU Human Brain project. The origin ERC project LIFEGATE has developed minimally invasive (hair-thin) endoscopes for advanced applications in neuroscience, and brought about a solid route to their commercial outreach. The instruments rely on state-of-the-art digital holographic methods combined with high-performance computing. They offer uniquely detailed observations in unprecedented depths of living, yet anaesthetized, animal models, making them particularly suitable to studies of connectivity of neuronal cells inside their natural environment. This proposal, entitled WOKEGATE, represents a powerful extension of this concept, enabling imaging-informed, single-cell specific activity monitoring and control of deep neuronal circuits in fully awake and behaving animals. The prospect is centred around a novel M3CF fibre probes which emerged within the origin ERC project LIFEGATE, outside its proposed research agenda. The project aims for (i) necessary technological amendments to incorporate this opportunity into the holographic endoscope geometries, (ii) a direct verification of this prospect in in-vivo studies through the network of existing research partners and (iii) paving the way for commercial translation of such empowered scientific instrumentation. Successful acquisition and execution of the WOKEGATE will enable future perspectives of this promising te