RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Femtosecond opto-magnetism and novel approaches to ultrafast magnetismat the nanoscale' under Seventh Framework.

assistant: **Concept**

The aim of this proposal is to create a training network in the newly-emerging multidisciplinary field of “nano-opto-magnetism”, a new scientific area with novel technological opportunities at the junction of coherent nonlinear optics, nanoscience and magnetism. The impact on society of this newly emerging field is potentially very high, therefore it is decisive that now young researchers are trained and equipped, so that they can become future leaders. We aim at achieving this by an integrated combination of a high-quality training program and their direct involvement in front-line research.  In the research program we want to investigate nonthermal effects of light on nanomagnets in order to obtain a comprehensive understanding of physical mechanisms leading to a highly efficient ultrafast (10-12 seconds and faster) optical control of magnetism at the nanoscale. Such scientific breakthroughs are expected to develop novel technology for unprecedented fast (THz) opto-magnetic recording.  A high-level training program firmly embedded in a consortium of both academic and industrial partners is designed to create a unique training environment to educate a new generation of young researchers in this interdisciplinary, recently emerging area of nano-opto-magnetism. In order to advance the young researchers career development, the industrial relevance of this research as well as the involvement of industrial partners is fully exploited.  In addition to the scientific and networking training, this offers unique opportunities for training of complementary skills of the fellows such as training in intellectual property rights, patent writing, commercial exploitation of the results and research-and-development policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Plight of Pelagic Primary Producers in a Changing Marine Environment' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The P4 fellowship will test the impact of past climate extremes on marine ecosystems using coccolithophores, a group of marine primary producers that experienced first order effects of climate and hydrodynamic changes in ancient pelagic oceans. Here we will use sedimentary materials of exceptional quality drilled during the International Ocean Discovery Program Expedition 361: South African Climates (January-March 2016) from the Mozambique Channel (Site U1476), the Natal Valley (U1474), the Agulhas Plateau (U1475), and Cape Basin (U1479), to reconstruct surface water biotic response during the Mid-Pliocene Warm Period (MPWP; 3.264 to 3.025 Ma), an interval considered to be the closest analogue for future warm climate. For the first-time, recovery of a complete Pliocene/Pleistocene succession in this region offers an unprecedented and timely opportunity to investigate episodes of major ocean and climate reorganizations during the Neogene period. With this, P4 is original and novel, being able to combine biological (assemblage composition), physical (volume and mass estimates) and geochemical (trace elements, stable isotopes) coccolithophore-derived datasets for understanding the climate of the MPWP, and explore its link with the past dynamics of the greater Agulhas Current system. P4 is innovative and collaborative, using state-of-the-art analytical techniques, and in combination with other proxies from ongoing works of other Expedition 361 scientists, offer a broad context for understanding 21st century global climate vulnerabilities. The resulting palaeoclimate datasets, coupled with real-time ecosystem data collection and numerical modelling, will provide a unique ‘test-bed’ for future model inter-comparisons. Furthermore, an exceptional set of training and transferab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Comparative structural genomics of viral enzymes involved in replication' under Sixth Framework.

assistant: **Concept**

This project aims to perform a ground-breaking impact on the identification of potential new drug targets against RNA viruses through comprehensive structural characterisation of the replicative machinery of -300 RNA viruses. RNA viruses are major human pa thogens (>350 identified) causing millions of deaths annually. The VIZIER team brings together the leading authorities on RNA viruses available in EU & more, with P4 facilities, as well as leaders in the field of structural genomics, with an adapted Management & Training structure. VIZIER aims to characterise RNA viruses (no DNA stage in their repl. cycle) of 3 genetically different classes: double-stranded and single stranded RNA viruses with positive & negative polarity. Their replicative m achineries are the most conserved and essential viral components, thus are attractive targets for antivirus therapy. The core enzymes/proteins of the replication machinery (polymerases, helicases, capping enzymes, NTPases, proteases, ancillary replicative proteins) will be characterised and compared. One unique feature of VIZIER is the integration of major structural effort within a broad multidisciplinary study, having virology upstream and target validation (lead design) downstream. As a result, the imple mentation plan of the VIZIER project is structured into 5 interacting scientific sections: (i) bioinformatics, for genome annotation, target selection and data integration; (ii) virus production and genome sequencing; (iii) HTP protein production (2000-300 0 targets); (iv) HTP crystallization and structural determination and (v) target validation, to assess the function of enzymes and design strategies for virus inhibition. New tools for protein production and distributed X-ray crystallography will be develo ped and validated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Unraveling the impact of pathological Tau phosphorylations on the early Tau interactome in Alzheimer's disease'.

assistant: **Objectives**

The Tau protein during Alzheimer's disease (AD) becomes hyperphosphorylated, misfolds, and aggregates into neurofibrillary tangles (NFTs). Despite knowing the involvement of Tau in AD, the exact mechanism that drives Tau-mediated toxicity is largely unclear. Studying the Tau interactome is an excellent way to decipher the mechanism of Tau toxicity. Most interactome studies have primarily focused on Tau interactions related to NFTs, which represent the mature form of aggregated Tau. This emphasis has led to the overlooking of early-stage Tau interactions, mainly due to the lack of tools to access early Tau forms. My aim is to investigate the Tau interactome at these early stages, which are crucial in AD pathology. I hypothesize that extensive phosphorylation of Tau in the early stages of AD significantly alters its protein interaction network. This alteration contributes to Tau aggregation and subsequent toxicity in AD. To address this hypothesis, I will use an interdisciplinary approach to systematically identify interacting proteins associated with early Tau forms (non-phosphorylated, site-specifically phosphorylated, and hyperphosphorylated). I will use a protein semisynthesis technique to generate early Tau forms and employ affinity purification-mass spectrometry to identify the interactome associated with them from human brain tissue. Unique interacting proteins of Tau forms detected from the proteomic data, will be assessed in high-throughput Tau biosensor-based cellular screening to identify potential Tau aggregation modifiers. Finally, in vitro biophysical studies will be conducted to characterize the molecular interactions between Tau modifiers and Tau forms. The findings from this project will advance our mechanistic understanding of Tau phosphorylations in AD,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Eating Out: Habits, Determinants and Recommendations for Consumers and the European Catering Sector' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Current lifestyle and sociodemographic developments have lead to an increase in eating out in Europe. The frequency and nature of the out-of-home dietary intake may posit risks for developing nutrition-related disorders and chronic diseases. However, the information on the out-of-home dietary intake of European populations is limited. The aim of the HECTOR project is to establish a platform for collaboration between the scientific community, consumer associations, and 13 catering-related enterprises, including 7 SMEs, so as to analyze practices of European catering enterprises and assess food types and quantities provided (food supply) and to understand the characteristics and determinants of out-of-home dietary patterns (food demand). In the HECTOR project individual-based food consumption data collected in 15 European countries will be analysed in order to: (1) evaluate the prevalence of out-of-home food consumption; (2) identify out-of-home dietary patterns, including meals, foods, and nutrients; (3) compare dietary intake within- and out-of-home, at national and regional levels, when possible; (4) evaluate the effect of sociodemographic, lifestyle, and anthropometric determinants on food choices when eating out; (5) compare the out-of-home dietary intake with national and international recommendations and estimate, through an innovative approach, optimal out-of-home dietary patterns. The findings after the evaluation of both food supply and demand will be translated to a common strategic action plan for enhancing the quality and safety of out-of-home food choices of the European consumers. The action plan will be pilot tested in the SMEs of the Consortium to evaluate its effectiveness. Moreover, the project aims to exploit the use of data on out-of-home food expendi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel Oxides and Topological Interfaces for quantum Computing Electronics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Todays quantum computers are suffering from a very high error rate due to decoherence (i.e. loss of quantum information) in their qubits fabricated with superconductors junctions or semiconductors quantum dots. The goal of this proposal is to research radically new materials and architectures to build a fault-tolerant qubit device on Silicon substrate (i.e. scalable), that will be immune to decoherence problems.In NOTICE, we will design and synthetize novel crystalline perovskite materials, monolithically integrated on a Silicon substrate, with topological insulating properties to enable the generation of Majorana fermions at the heterointerface with a superconductor. The generated Majorana fermions will hold the quantum information in such Majorana qubit which will be resistant to noises and fluctuations due to the topology effect if stable and robust materials presenting the desired properties can be obtained.Bismuth-based perovskites were down-selected as topological insulator (BaBi(O,F)3) and superconductor ((Ba,K)BiO3) oxides due to the very strong Spin Orbit Coupling present in Bi which will favorize the efficient generation of Majorana fermions at the perfect (pristine) BaBi(O,F)3/(Ba,K)BiO3 heterointerface. With Molecular Beam Epitaxy growth approach together with advanced characterization techniques such as Angle-Resolved PhotoEmission Spectroscopy measurements and ab-initio simulations on the topological insulating properties of the perovskites, we aim to generate a stable topological interface leading to the efficient generation of Majorana fermions. This breakthrough will enable us to fabricate chiral Majorana devices on a Silicon technology platform, providing both reliability and manufacturing scalability.NOTICE results will pave the way to fault-tolerant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PROMOTION STRATEGY FOR EUROPEAN ELECTRONIC HEALTHCARE RECORDS' (PROREC), addressing dissemination and exploitation.

assistant: **Impact**

PROREC is aimed to promote uniform comprehensive, communicable and secure European electronic healthcare records (EHCRs) offering cost-effective simpler access for both patients and professional users. Its approach will be to assist and support all EU EHCR-related telematics and similar projects, nationally and internationally. EHCRs will be promoted via a permanent network of centres for disseminating records information, later likely to be a fully-fledged European institution.The main goal of PROREC is to promote and coordinate the European wide convergence towards comprehensive, communicable and secure Electronic Healthcare Records (EHCR)This will be achieved by coordinating and supporting the European Commission's Telematics Applications for Health projects and other initiatives in the area of EHCRs, both nationally and internationally.The most important activity to be carried out is promoting the widespread use of Electronic Healthcare Records by installing in Europe a permanent network of centres focusing on the dissemination of information related to electronic healthcare records. This network will be backed up by a European Steering Committee (PROREC International), simulating and preparing the activities of what should become in a later stage a true European Institution on the Electronic Healthcare Record. One of the intermediate goals of this purposeful strategy is to ensure that bodies such as CEN/TC251 at the one hand, and EC Informatics programmes at the other hand, meet their purpose of providing standards and highest quality research to enhance the care process for patients and users. But perhaps even more important, PROREC's aim is to reach all actors in the field, such that even the smallest initiative taken independently" by some organisation, company
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sensing and Signalling in the Innate Immune Response, using Drosophila as a Model' (IMMUDROSO) targeting Seventh Framework.

assistant: **Abstract**

The project seeks to advance our knowledge of the innate immune system at two different but complementary levels, sensing and regulation of signalling. The first aim is centred on danger signals, and how they activate the immune system. We propose to use high-throughput RNA sequencing, molecular biology, fly and bacterial genetics to investigate the global network of genes and pathways that are involved in either endogenous (DNA and chromatin components) or exogenous (pathogen virulence factors) danger signal sensing. Drosophila is used here as a model system to analyse the complexities of host-pathogen interactions. As many bacteria use a common set of virulence factors to target different hosts, this work should lead to the identification of new defence genes and mechanisms in human. The second aim seeks to understand the mechanisms that fine-tune NF-ºB signalling in Drosophila and in mammals. NF-ºB mediates every aspect of inflammation and immune response through transcriptional programs that have to be orchestrated by yet unknown regulatory layers. The ability to effectively target inflammatory diseases for therapeutic intervention requires knowledge of the intricacies of these regulatory layers. First, we propose to characterize the molecular function of a new modulator of NF-ºB signalling that we have recently discovered, by using yeast two-hybrid screens, mass spectrometry and Drosophila genetics. In parallel, we propose to analyze the role of newly discovered and evolutionary conserved small RNAs in the regulation of the innate immune response in Drosophila. This exciting new area of research should lead to a better understanding of the control of immune reactions, one of the most important goals for medical research in the next decade.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'LOW-TEMPERATURE HEAT EXCHANGERS BASED ON THERMALLY-CONDUCTING POLYMER NANOCOMPOSITES' to be submitted under Seventh Framework.

assistant: **Abstract**

Low temperature heat recovery is often limiting the energy efficiency of industrial processes. Low temperature differences imply large exchange surfaces which are unfeasible from the economic (expensive metal are needed to withstand the presence of condensates) and technical (too large volumes for the specific application contexts) viewpoints. The present project aims at developing nanofilled-polymer-based heat exchangers enabling: i) effective heat conductivity due to the percolation network of carbon or metal fillers; ii) cost reduction compared to metal materials (stainless steel, Cu-alloys,…); iii) design flexibility for an intensive volume exploitation; iv) superior corrosion resistance; v) promotion of the highly effective drop condensation with hydrophobic polymers. Three main application areas are devised: 1. Intercoolers increasing the efficiency of large diesel engines, where heat conductive plastics can provide a cheaper alternative to Cu-alloys when seawater is used as the cooling media (e.g. large naval engines or power plants close to sea side). 2. Heat recovery systems from combustion flue gases acting below 300°C, where commercial metal-based systems loose cost-effectiveness. 3. Application in the chemical and process industries where harsh chemicals or corrosive environments have to be faced. The project is divided into three main work lines: i) development of compounds in which a range of polymers (nylon, PET,…) and fillers (carbon fibres, carbon nanotubes, metal coated nanoparticles, …) will be considered; ii) tailoring of plastic forming techniques (injection moulding, pressing, extrusion); iii) manufacturing & testing of up to two proof-of-concept heat exchangers. The partnership includes two Universities (POLITO-I, TUBAF-D), two research centres (C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Acousto-electric single photon detector' (2002-2006).

assistant: **Concept**

We propose to develop a novel photon detector for applications in quantum information processing and for general applications in areas where detection of ultra weak photon fluxes is required. The proposal addresses the demand in quantum information processing for a single photon detector that can discriminate between different numbers of photons in a light pulse.Operation of the detector is based on measurement of a number of electrons and the holes created in a semiconductor layer by a light pulse. The detector exploits the charge transport by surface acoustic waves in order to realise a design in which a big photon absorption area (providing a high photon collection efficiency) is spatially separated from a microscopically small charge detection area (providing the sensitivity of charge measurement at the single electron level). The proposed design facilitates achieving a high quantum efficiency of the detector.In addition to the photon counting regime (suitable for the quantum information processing applications) the detectors employing the acoustic charge transport can be used for general purposes. If the counting of single photons is not required, the acoustoelectric detectors can be quite simple in design and operate at room temperatures. In particular, we expect that the acoustoelectric detector can be competitive in detection of ultra weak light fluxes.