RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of Laser-Based Technologies and Prototype Instruments for Genome-Wide Chromatin ImmunoPrecipitation Analyses'.

assistant: **Objectives**

Deciphering the complexity of chromatin-encoded information is the prerequisite for understanding the regulatory circuits governing development and (patho)physiology. Transcription factors and epigenetic modulators translate chromatin-embedded information in a dynamic and cell/gene context specific manner to orchestrate homeostasis, growth and differentiation. To date, the most powerful and commonly used approach is immunoprecipitation of chemically cross-linked chromatin (XChIP) coupled with single gene or global analysis using DNA tiling arrays (ChIP-chip) or parallel single molecule sequencing (ChIP-seq). At present, serious limitations of the XChIP technology preclude factor-DNA interaction studies at dynamic ranges below minutes. Moreover, conventional XChIP cannot be used to study samples of <106 cells or cell populations within complex biological samples. Based on established proof-of-principle experiments, the multidisciplinary ATLAS consortium will develop novel types of femtosecond (fs) UV tunable lasers to induce highly efficient DNA-protein crosslinking for ChIP analyses with unprecedented precision and reproducibility, and extending the present dynamic time range by order of magnitudes. ATLAS will further validate LaserChIP (LChIP) technologies and integrate them e.g. with manipulation of irradiated (frozen) tissues slices and microfluidic cell sorting systems. Combining LChIP with proximity ligation approaches will facilitate the analyses of cell-selective (epi)genetic programs on small pre-defined cell populations down to the single cell level. Integration of innovative SMEs with physicists, oncologists, biologists, chemists and mathematicians secures efficient introduction and application of LChIP in basic and translational research. This consortium has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Network representations of contextual memory in a neocortical circuit' (RSCmemory), addressing dissemination and exploitation.

assistant: **Impact**

How are memories formed and how do we remember them? Despite decades of memory research, these are still unanswered questions. There is consensus that the hippocampus is a key circuit for forming new memories. According to the classical model, memories that initially depend on the hippocampus, mature over time, and become increasingly dependent on distributed networks in the neocortex. While there has been great progress in understanding the molecular and genetic substrates of memory, how memories are represented by neuronal ensembles is still poorly understood. This is in part due to the lack of tools to monitor neural populations densely and repeatedly during memory formation and memory recall. The advent of two-photon microscopy and activity indicators that allow to measure the activity of nearly all neurons in a circuit, has created new opportunities to address these questions. To study how the neocortex supports memories, I will study a circuit called the retrosplenial cortex (RSC). This structure receives dense and direct input from the hippocampus and is therefore a key network to study memory. There is also substantial support for a role of RSC in memory recall, but the network mechanisms remain unknown. To study this, I will establish a novel head-fixed contextual fear conditioning task for mice that enables monitoring the activity of thousands of neurons in the RSC while conditioning under the microscope. The high spatial resolution of this method also enables measuring the activity changes of hippocampal axons projecting to RSC, thus allowing me to also measure the synaptic input to RSC. Finally, I will establish a novel technique to monitor hippocampal oscillations related to memory consolidation (so-called sharp wave ripples) and neural activity changes in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integral Open Technology for Industry 4.0' under Horizon 2020.

assistant: **Concept**

The Industry 4.0 is creating new opportunities to enhance the competitiveness of industries, a sector accounting for 2M enterprises, 33M jobs and 60% of  EU productivity growth. However, SMEs risk missing the train of digitalisation because existing proprietary technologies for automation and control are expensive and do not provide the flexibility required in dynamic industrial environments.The IOTI4.0 project aims to disrupt the market of industrial automation and control (a market worth $153.3Bn) through a highly innovative business concept: the use of Open Source Hardware (OSHW) in professional industrial environments. OSHW brings great benefits to the user in terms of cost, flexibility, security and interoperability. It also delivers growing benefits to the economy. However existing solutions are not sufficiently developed nor professionalised to serve the needs of industry. IOTI4.0 will bring into the market the first interoperable, standardised (IEC61131-compliant) OSHW-based technology for Industry 4.0 (both hardware devices and intelligent programming software). It will do so at a much more affordable price (50% cheaper on average) thanks to the fact that OSHW does not have the added cost of a proprietary licence. Applicable to industries of any sizes and sectors, IOTI4.0 will make digitalisation accessible to any SME willing to transition to Industry 4.0.  The company behind IOTI4.0 is Boot & Work, a young SME (Barcelona, 2012) specialised in OSHW solutions for industry. With a team of 16 staff, in just a few years, we have achieved a track record in international sales (1,200 clients in 85 countries). IOTI4.0 is the cornerstone of our strategic plan to accelerate growth. With an investment of 1.4M€, the new products and software services will be ready by end-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Femtosecond coincidence imaging towards understanding mechanisms of coherent Quantum control of chemical dynamics'.

assistant: **Objectives**

The main objective of this proposal is to provide advanced research training of dr. W.G. Roeterdink at the Combustion Research Facility (CRF), Sandia National Laboratories in Livermore, California, on the emerging technique of Femtosecond Coincidence Imagi ng. This technique gives the most complete information possible about the electronic and nuclear changes during chemical reactions, all in real-time at the femtosecond time scale of the dynamics. Femtosecond Coincidence Imaging is pioneered in the laborat ory of dr. C.C. Hayden at the CRF and represents major advantage in the ultrafast time-resolved study of chemical dynamics. Dr. Roeterdink will be trained in this new laser based technology and will transfer this expertise during the return phase to the L aser Centre Vrije Universiteit (LCVU) Amsterdam, The Netherlands. At the LCVU, a member of LaserLab-Europe, he will lead the construction of a new femtosecond coincidence imaging facility, expanding the research facilities for visiting researcher within th e European Research Area. We will use the coincidence imaging technique in combination with advanced femtosecond pulse shaping to elucidate the mechanism of coherent quantum control of chemical dynamics. Dr. Roeterdink will do research in a world leadin g laboratory in the USA with unique cutting-edge technology in lasers and advanced single particle imaging detectors. Furthermore, he will be able to build up a scientific network abroad of importance for the further development of applicant as a scientis t. The Marie Curie Outgoing International Fellowship will enable dr. Roeterdink to advance his abilities, expertise and skills to pursue a future independent scientific career in the European Reseach Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PROBE.LY - Web Application Vulnerability Scanning Suite for Agile Teams' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The number of publicly reported breaches with sensitive and business data exposed, has been increasing significantly year after year. Web application attacks are the most common attack pattern, with 40% of all breaches. These attacks exploit vulnerabilities that were introduced in the applications inadvertently by their developers.The most popular solution companies use to find vulnerabilities is to hire penetration testing services. However, these services are a) costly because they are performed manually and b) to manage all of the findings is very time consuming. Due to these two reasons, companies don’t test the security of their applications as frequently as they should.Probe.ly automates web vulnerability scanning. Our customers can cost effectively scan web applications and efficiently manage the lifecycle of the vulnerabilities found in an intuitive web interface. As opposed to Web Application Penetration testing, Probe.ly, since it is automated, can offer a very competitive price and address a new market of small companies that do not have the budget for penetration testing services. The objective of our proposal is to enhance R&D to create a viable solution that helps companies to identify vulnerabilities in their web applications, contributing to safer applications and a safer Internet. We believe that, as opposed to the majority of our competitors, targetingDevelopers is the right way, since they are the ones that introduced the vulnerabilities, but also because we can take a more educational role by explaining to them why the vulnerability exists, its impact and how to avoid future problems.Our market is worldwide and is targeted at companies that have a development team and build online services. Our pricing is based on a subscription model (SaaS) with sel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Neuronal Alternative Splicing and RNA-Editing Crosstalk'.

assistant: **Objectives**

A long-standing question in biology has been to determine how the mammalian central nervous system (CNS) achieves its dramatic cellular complexity and connectivity. Notably, mechanisms increasing transcript diversity, particularly alternative splicing (AS) and RNA-editing, have critical roles in the mammalian CNS development and function. However, it is still unclear whether the crosstalk between these two processes constitutes an additional RNA-mediated regulatory layer contributing to the complex mammalian CNS. Thus, the main goal of NeuroASPECT is to determine the extent, dynamics and functional relevance of the crosstalk between AS and RNA-editing in the mammalian CNS. To tackle this general goal, I propose the following specific aims: 1) Elucidate the extent of co-regulation between AS and RNA-editing events in the CNS by building a comprehensive catalog of neural co-regulated AS-editing events in mammals and explore their evolutionary conservation in other vertebrates. 2) Assess the crosstalk between AS and RNA-editing in neural differentiation by analyzing transcriptomes of cells with impaired RNA-editing. 3) Characterize the functional impact of AS and RNA-editing crosstalk on mouse neurogenesis. I expect this work will uncover RNA networks established between AS and RNA-editing that are involved in shaping and regulating the CNS transcriptome. Moreover, it will also contribute to a better understanding of the biological functions and regulation of AS and RNA-editing, in both an independent and synergistic manner. In addition, the functional characterization of the AS-editing crosstalk could ultimately reveal alterations in which the lack of coordination between AS and RNA-editing can lead to the development of neurological disorders, thus offering potential tar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Assessment and critical evaluation of antibiotic resistance transferability in food chain' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The emergence and evolution of antibiotic resistance in bacteria represents a major financial and societal cost. Despite concern that the use of antibiotics in the food chain contributes to the development of resistant bacteria, research has yet to provide the data necessary for the development of an effective risk management strategy. Risk assessment of antibiotic resistant, nonpathogenic bacteria present in the food chain requires data on the sources of these bacteria, their genetic composition and potential for resistance transfer. This project, named Assessment and Critical Evaluation of Antibiotic Resistance Transferability in Food Chain (ACE-ART) will provide a critical evaluation of the role of antibiotic use in agriculture and in the prophylaxis and treatment of disease in humans. Unlike other studies, focused on pathogens, this project is focused on non-pathogenic bacteria. Strains belonging to Lactobacillus, Bifidobacterium, Lactococcus and Streptococcus thermophilus will be used as they can be found in a wide range of habitats. Moreover, they are industrially important bacteria, used as starter cultures for fermented food. Within this project the importance of these bacteria as a source of antibiotic resistance genes (Work package 1) will be assessed. The project will also examine the transmission of resistance in the environment and in the animal and human gut (WP 2) and establish the genetic basis of the detected resistances and transmission mechanisms (WP 3). Dissemination of results and links with consumers' organization will be provided by WP4; an industrial platform will assure the link with 14 industrial producers of starter cultures. This research will establish a dataset on the occurrence and transmission of antibiotic resistance, which will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ULSI most research activity' under Fourth Framework.

assistant: **Concept**

to perform exploratory work on new device architectures suitable for the 0.13 micron CMOS generationto consider the introduction of new materials in a standard CMOS process flowto compare the various technological solutions against the target specificationsThis project is an exploratory work on advanced MOSFET architectures suitable for the 0.13 micron CMOS generation. Technically speaking, this project focuses on the optimisation of the device architecture (e.g. Ground Plane), the emerging new materials (e.g. SiGe, TiN, Ta2O5, etc.) and the evaluation of various technological solutions against the end-user defined specifications. The project is divided into four workpackages: Channel Engineering, Gate Engineering, S/D Engineering and Device Specifications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Parton Distribution Function determinations for the future of particle physics phenomenology' to be submitted under Horizon 2020.

assistant: **Abstract**

The first run of data taking at the Large Hadron Collider (LHC) at CERN culminated with the discovery of the Higgs boson announced in July 2012 and represented the beginning of a new era in high-energy particle physics. During the LHC Run II, which will start at the beginning of 2015 with the collider running at higher center of mass energy, the experimental collaborations will collect a large number of high quality data that will allow us to test our understanding of elementary particle physics to unprecedented levels and have the potential of revolutionizing our knowledge of fundamental physics. In order to fully exploit the potential of the experiments for precision studies of the properties of the Higgs boson and for searches of physics beyond the Standard Model it is of paramount importance to have access to accurate theoretical predictions for both background and signal processes. Parton Distribution Functions, which encode the information on how quarks and gluons are bound inside hadrons, are one of the fundamental ingredients of theoretical predictions for observables at hadron colliders. Indeed they are often the dominant source of uncertainties on predictions for precision observables at the LHC.The goal of the NEXTGENPDF project is to make use of all the relevant experimental information from the LHC experiments, the most accurate theoretical predictions, innovative techniques for estimation of theoretical uncertainties and advanced statistical inference methodologies to deliver new sets of Parton Distribution Functions that match the precision requirements of the experiments at the LHC Run II and at future colliders, maximizing their potential for discoveries of new physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Solid sample introduction systems in icp-ms - microwave sample pretreatment and nebulization versus laser ablation' in the context of a Fourth Framework call.

assistant: **Objectives**

The aims of this Research Project are: 1.- To compare two ways of solid sample introduction in ICP-MS, i.e., solid dissolution and further nebulization versus laser ablation. 2.- To evaluate, for the first time, a new mtcrowave thermal nebulizer, which has been designed in our laboratories, as a simultaneous system for sample digestion and nebulization. 3.- To suppress (or to reduce) the interferent effects of the acids in ICP-MS. To achieve this purpose, we shall try to study the influence of a conventional desolvation system on the analytical behaviour of an ICP-MS instrument when using the MWTN. The experiments will be performed by characterizing the drop size distributions of tertiary aerosols, solvent and analyte transport rates and ionic intensities. 4.- To determine for each kind of sample the maximum particle size which is fully atomized, when using laser ablation. In this case, the particles will be classified in different size groups and each group will be separated prior to be introduced in the ICP-MS instrument. The amount of analyte contained in each group of particles will be determined. Therefore, the relationship between the analytical signal and the analyte transport rate will allow us to know whether the atomization efficiency of the plasma has worsened or not as the size of the particles is increased. Training content (objective. benefit and expected impact) The training objective would deal with a more complete understanding of the process that take place when the solid aerosol" is generated by laser ablation and when this aerosol interacts with the plasma. The applicant is not familiar with techniques like Laser Ablation and ICP-MS. Therefore, this project would permit him to achieve a better knowledge about this techniques. Links with industry i in