RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A handheld, ultra-sensitive device for rapid contactless explosive vapour detection in open air, based on Ion Mobility Universal Sensor Technology' (I-MUST), addressing dissemination and exploitation.

assistant: **Impact**

Explosives detection currently represents the biggest security challenge, being easy to acquire with limited resources and difficult to be detected in real-time. Recommended procedures for explosive detection are inherently unsafe: due to current technological limitations, EU regulations only prescribe screenings on a variable percentage of randomly chosen passengers. Being not portable, such devices can only be installed at screening lines - but in Brussels 2016 explosions happened way before them. Moreover, existing devices just allow to analyse swabbed points instead of the passengers’ total body. In the meantime, those procedures are slow (up to 30 s/passenger) and intrusive, requiring physical contact (swabbing): two major drawbacks, considering that airports competition is based today on passenger experience. Eye on Air developed I-MUST, a handheld disruptive device based on a proprietary, ultra-thin and high sensitive Ion Mobility Spectrometry sensor.  Embedded into I-MUST, it ensures the most secure detection of explosives, with a sensitivity 500 times higher than its competitors (0.1 ppb) and the detection of  >150 compounds, i.e. 3 to 5 times more compounds than currently used technology. I-MUST can be used not only at screening lines, but everywhere in public places, allowing to introduce the concept of a “distributed security” and, thanks to the brief time of analysis (2 s), 100% passengers can be scanned. By using short ion beams and a small, annular drift space, Eye on Air obtained such performing, enabling technology, whose features have already been confirmed in October 2015 by TNO, the Dutch research institute devoted to the certification of airport screening devices. During Phase 1 project, Eye on Air will assess the scale-up industrialization plan and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INTERNATIONAL NETWORK OF RAW MATERIALS TRAINING CENTRES' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

INTERMIN will create a self-sustainable long-term lasting international network of training centres for professionals. This project involves educational and research institutions in the EU and the leading counterparts in third countries, based on specific country expertise in the primary and secondary raw materials sectors. The network will map skills and knowledge in the EU and the third countries, identify key knowledge gaps and emerging needs, develop roadmap for improving skills and knowledge, as well as establish common training programmes in the raw materials sectors. In line with the EU's strategy for international co-operation in research and innovation (COM(2012)497), the consortium will seek international collaboration, fostering and exploring  synergies with the relevant EU Member States initiatives


**Keywords:** Raw materials, Network, Training, Education, professionals, employers, international, framework, geosciences, self, sustainable, Europe, geologist, mining engineer, Earth Sciences
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced MIcroscopy of Attine ant BacteriaL Endosymbionts' (AMIABLE) targeting Horizon 2020.

assistant: **Abstract**

SummaryMost animals crucially depend on bacterial symbionts for digesting food and for optimal health, and such associations are particularly relevant for farming societies that produce their own food. Next to humans, the fungus-growing ants have realized the largest and most complex animal societies on Earth and also these societies depend on the services of multiple bacterial symbionts. The experienced researcher is a cell biologist with state-of-the-art training in electron microscopy who teamed up with the Copenhagen Centre for Social Evolution (CSE) to realize a uniquely interdisciplinary research program of microbial symbiosis. She focuses on three abundant gut bacteria of fungus-growing ants that were recently discovered by the host group, and which appear to function as nutritional and disease resistance mutualists in this complex symbiosis that has become one of the best-studied model systems of social evolution. The objectives of this project are: 1. To reconstruct the acquisition process of symbiotic bacteria during development of individual leaf-cutting ants; 2. To resolve structural adaptations of the bacteria for intracellular versus extracellular lifestyles. Neither of these objectives have been addressed before and both have high potential to change the way in which biologists think about bacterial symbioses. The project includes training-through-research of the researcher in molecular biology, bioinformatics and evolutionary theory, and considerable knowledge transfer in advanced microscopy from the researcher to the CSE host group. The project has been initiated with CSE funding, proven to be very synergistic and highly feasible, and the researcher has already built a collaborative network in Copenhagen. The present application seeks to realize the pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Nanomedicine and Hadrontherapy'.

assistant: **Innovation**

Cancer is one of the most feared diseases. Radiotherapy is commonly used in about 50% of all cancer patients. Although the radiotherapeutic protocols have been improved significantly, only a limited number of patients are entirely cured and severe side effects are often induced. Hadrontherapy and protontherapy are approaches superior to conventional photon radiotherapy because of the maximal energy they deposit at the end of the track (the Bragg peak) and the absence of damage induced behind the tumor. However, the technique is limited by the damage caused along the beam path in healthy tissue located in front of the tumour.Dr. Lacombe's work focuses on improving the hadrontherapy performances using metal nanoparticles (NPs) as radiosensitizers. This is a highly innovative strategy aiming at increasing efficiency and tumour targeting of the treatments. So far, the group focused on the physical properties of the nanoparticles. The objective of my project is to characterize fully the biological effects induced by NPs in DNA and living cells, submitted to medical ion radiations. During the project I will address the cellular toxicity, localization, uptake and quantification of NPs, and I will specifically dissect the cellular response to the combined treatment of NPs and fast ions/protons down to the molecular pathways. To answer these questions, I will make use of the highly advanced experimental instruments and methods available at the host institution and collaborating laboratories. The results obtained during this project will be highly relevant not only for the research community, but also for the industrial sector that synthetizes the NPs and for the medical community who will be closely involved in the project. This multidisciplinary research at the interface of phy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular mechanisms of acute oxygen sensing.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Oxygen (O2) is essential for life on Earth. This proposal deals with the study of the molecular mechanisms underlying acute O2 sensing by cells, a long-standing issue that is yet to be elucidated. In recent years, the discovery of hypoxia inducible transcription factors and their regulation by the O2-dependent hydroxylases has provided a solid framework for understanding genetic responses to sustained (chronic) hypoxia. However the mechanisms of acute O2 sensing, necessary for the activation of rapid, life-saving, compensatory respiratory and cardiovascular reflexes (e.g. hyperventilation and sympathetic activation), are unknown. While the primary goal of the project is to characterize the molecular mechanisms underlying acute O2 sensing by arterial chemoreceptors (carotid body –CB- and adrenal medulla –AM-), we will also extend our study to other organs (e.g. pulmonary and systemic arteries) of the homeostatic acute O2-sensing system. We will investigate the role of mitochondria, in particular complex I (MCI), in acute O2 sensing. Previous data from our group demonstrated that rotenone, a MCI blocker, selectively occludes responsiveness to hypoxia in CB cells. In addition, our unpublished data indicate that sensitivity to hypoxia (but not to other stimuli) is lost in mice with genetic disruption of MCI genes in CB and AM cells. We have shown that the adult CB is a plastic organ that contains a population of multipotent neural stem cells. Hence, another objective of the project is to study the role of these stem cells in CB modulation (over- or infra-activation), which may participate in the pathogenesis of diseases. In the past, our group has made seminal contributions to unveiling the cellular bases of arterial chemoreception. The discovery of stem cells in the CB and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'SYnthesis and functionality of chalcogenide NAnostructures for PhaSE change memories'.

assistant: **Innovation**

The SYNAPSE project initially aimed at the metalorganic chemical vapor phase deposition (MOCVD) and study of chalcogenide single material, (core) and double material (core-shell) nanowires (NWs), for innovative multi-level phase change memories (PCM). If Ge-Sb-Te is the most studied material for PCM applications, In-based materials, like In-Sb-Te or In-Ge-Te alloys, are also promising, since they are featured by low reset current and high crystallization temperature, paving the way for performing data storage devices even in the automotive field. At the same time, a great attention is currently devoted to the chance to downscale PCM cells by employing chalcogenide NWs. In SYNAPSE, Ge-based and In-based single material (SM-NWs) will be first deposited by MOCVD on different substrates and using different bottom-up approaches, the vapor-liquid-solid (VLS) and the selective area growth (SAG). SM-NWs were originally expected to be in-situ MOCVD-coated by other phase change chalcogenides, to obtain core-shell nanowires (CS-NWs), both free-standing and buried in template matrix. Different material combinations (Ge-Sb-Te/In-Sb-Te/In-GeTe) had to be explored in the realization of the CS-NWs, in order to expand the memory level operational features of the obtainable PCM devices.Due to some delays and the impossibility to ask for an extension, a project redefinition during the second reporting period was necessary, so that the objective of obtaining core-shell nanowires was dropped, along with the optimization of conformal chalcogenide layers. The important goal of exploring NWs of different chalcogenide alloys, including Ge-based and In-based telluride remains, for their application to PCM devices both as single nanocells and in ordered arrays. This will anyway represent an impor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Realistic, accessible, and affordable models for surgical education'.

assistant: **Concept**

Breast cancer is the most common cancer in women and the second in cancer-related deaths. There were over 2 million new cases in 2018 , and this number is continuously increasing. To remove breast cancer, there are two main types of surgery: 1) Breast-conserving surgery (lumpectomy, quadrantectomy, partial mastectomy, or segmental mastectomy): A surgery in which only the part of the breast that contains the cancer is removed; 2) Mastectomy: A surgery in which the entire breast is removed, including all of the breast tissue and sometimes other nearby tissues. There are several different types of mastectomies. Some women may also get a double mastectomy, in which both breasts are removed. The return of women to their pre-cancer lives depends on the medical and aesthetic success of the surgery that they are going to go through. Modern oncoplastic techniques that are focused on conserving the breast tissue offer a better pathway for patient health and recovery. In order to excel in these techniques, surgeons need practice which requires hands-on manipulation of the breast tissue. However, the shortage of cadavers and organ models hinders the quality of surgical education. The students/surgeons-in-training practice on the very patients that they are sworn to take care off. There is a need for a reliable and sustainable training medium for ever-growing number of medical students and personnel. ReSurg: offers new-to-the-world solutions, a breast model that aims to improve breast surgery medical training, and a self-awareness model, a poster with a tactile breast model that contains lumps which should not be there, a campaign that encourages women to follow up with their routine exams through somewhat scaring them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Selective induction of PYROptosis in acute myeloid leukemia cells with VECTORized DPP9 inhibitors', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

DPP9 (dipeptidyl peptidase 9) is a cytosolic serine protease. It recognizes and cleaves N-terminal dipeptides containing proline at the penultimate position. The enzyme is currently receiving strong international attention after it was reported that DPP9 inhibition induces inflammatory cell death (pyroptosis) in Acute Myeloid Leukemia (AML) cells. Pyroptosis is a lytic form of cell death that also causes a pronounced, local upregulation of the innate immune system. This is of particular interest to leukemia treatment because the immune response to leukemic cells is strongly suppressed. Very recently, however, reports have been published that identify other, non-cancerous cell types that also undergo pyroptosis upon DPP9 inhibition. This raises questions on how selective and safe DPP9 inhibition can be as a therapeutic strategy in AML. The host reported the first selective, nanomolar DPP9 inhibitors in 2023 and also discovered the first DPP9-degrading PROTACs (unpublished data). PyroVectors mission is to selectively unleash these molecules pyroptosis induction potential against AML cells, by delivering them towards these cells with vector approaches. Given the general lack of knowledge on how to optimally target small molecules to AML cells, three molecules that recognize AML cells will be compared as vectors for DPP9 inhibitors: a monoclonal antibody, an AML cell-penetrating peptide, and a sialic acid analog. DPP9 inhibitors that are covalently linked to these 3 ligands, will be investigated in terms of internalization and pyroptosis induction in cells. Furthermore, AML selectivity and therapeutic potential in vivo will be characterized with the ultimate aim of validating the approach as a safe and effective therapeutic strategy for AML. Overall we are strongly convince
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TREAT - a system for balancing antibiotic treatment against development of drug resistance' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The goal of the project is to develop a framework for the building and testing of medical decision support systems. The framework is based on a novel technology for the construction of very large stochastic models. The project will demonstrate the value of the proposed framework through its successful application in a specific medical area, the antibiotic treatment of infections. The medical objective of the project is thus to develop and test a decision support system, TREAT, that can help doctors reduce substantially the large and rising mortality (about 100,000 annual deaths in Europe) associated with inappropriate antibiotic treatment of patients with severe infections, and help to curb the development of bacterial resistance to antibiotics. Achievement of this goal will, in its own right, be a substantial contribution to community social objectives in terms of improved quality of life and conservation of a natural resource that is rapidly being depleted: a flora of micro-organisms that have low resistance to antibiotics.The TREAT system will be installed and tested in hospitals in Denmark, Germany and Israel. An important aspect of this European dimension is the sharing of large and unique databases on bacterial infections owned by the partners in these countries. Resistant bacterial strains do not respect national borders and with the current level of travel, the problem of bacterial resistance cannot be solved at the national level. The results of the clinical testing are expected to show that1) TREAT can be integrated into the informational infrastructure of the involved hospitals,2) TREAT is clinically acceptable from the user interaction point of view, and3) TREAT can give major reductions in mortality, compared to current clinical practice.Based on these resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Auditory Processing Skills, Phonological Awareness and Literacy Development in Monolingual and Bilingual Swedish Children' (APPALIT).

assistant: **Innovation**

This project explores whether basic auditory processing abilities in children, specifically those concerned with tracking the rhythms of speech, can predict literacy in Swedish. The project builds on prior experimental work in English being carried out in the host laboratory (Professor Usher Go swami). Using new measures of children\'s ability to track the \andquot; beats\andquot; in the rhythm of speech, Go swami and colleagues have shown specific difficulties in these measures of rhythmic processing in dyslexic children, and superior ability to track the auditory cues associated with speech rhythm in precocious readers.If the relationships shown are causal, then(a) similar relationships should be found in other languages, and(b) basic auditory processing skills should predict literacy in two languages when children are bilingual.The causal link proposed is at the level of the development of phonological awareness. Phonological awareness is the ability to identify and manipulate sounds in words (e.g., to recognise that \andquot; cat\andquot; and \andquot; hat\andquot; rhyme). Go swami and colleagues have proposed that the ability to track the \andquot; stress beats\unquote; in speech is important for children\'s ability to represent phonological information at the syllable level, and in particular to pinpoint the vowel in any syllable (the vowel accounts for the major increase in amplitude in the speech signal yielding the \andquot; beat\andquot; of each syllable). The applicant has just completed a Ph.D. on the development of phonological processing in Swedish monolingual and bilingual children, for which she designed and standardised a range of new phonological awareness tasks. The current project hence capitalises on this new development by giving these phonological