RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrating GI into the information society - Accompanying measure to support the set up of a European Territorial Management Information Infrastructure' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Territorial management is a horizontal activity, a cross-disciplinary research domain. Geoscience supports many activities related to Earth management. The project aims at organising a network of excellence, bringing together the actors, including users of territorial management information. Such network will build a technical consensus on the basement of European GI Infrastructure: Reference data, data access policy, standards and interoperability implementation.The key issues of the project are:To cluster FP4 & FP5 projects working in that field, providing user's needs feedback to standard makers and raising awareness on the benefits of standards;To vulgarise information technology for decision makers and citizens, contributing to make data accessible to all;To bring together most of the European stakeholdersTo give the international dimension required in the frame of global market (NSDI, OGC, GSDI).Objectives:The AM aims organising a network of excellence, bringing together most of the stakeholders of the territorial management; a particular attention will be paid on user's needs.It will have to build a consensus on the technical issues that are the foundation of ETeMII:- reference data, data access policy,- interoperability, standard implementation- integration of space tools: GNSS, EO and telecom- active participation to global initiatives: OGC, ISO, GSDI.Awareness activity is an important component of the AM, promoting contribution to European Geographic Information Infrastructure, using metadata services, implementing standards, using reference data.Reference data: The objective is to reach a European and global (GSDI) technical consensus on the definition of reference data and making them available, at affordable cost.Metadata: through workshops, awareness activ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Matrixins inhibition and drug design'.

assistant: **Innovation**

Matrix Metalloproteinases (MMPs), also named matrixins, are important targets for drugs to combat diseases as diverse as arthritis, atherosclerosis and cancer. MMPs are indeed of great importance in physiological and pathological tissue degradation. The molecular design of specific inhibitors will lead to therapeutic intervention in these diseases. First generation MMPs inhibitors are already available, but their efficacy and specificity needs to be improved. The overall objective of this transnational proposal is to coordinate various European scientific teams and expertise in chemistry, biochemistry, molecular and cell biology, as well as in cancer invasion and metastasis. The aim is to promote rapid exchange of knowledge, technical expertise, reagents and personnel involving 8 teams from 5 European Countries. It is anticipated that Coordinated European Research on structural biology of MMPs complexed with specific inhibitors and development of biochemical entities with optimised activities will lead to a rapid increase in information about the structure and target specificity of matrixins. This could not be attained by individual activities alone. It will lead to the molecular design of selective MMP inhibitors specific for each enzyme. These inhibitors could be clinically useful drugs for treatment of cancer and other diseases. Four major measurable objectives are addressed and will be explored together in this Transnational European Programme (for details, see section 7: Partnership"). 1) Production of 6 MMPS and synthetic inhibitors specific for each enzyme, as well as standardization of assay procedures to evaluate the effect of these inhibitors. Our interest will focus on 6 different MMPs that play a key role in cancer invasion and two families of inhibitors (sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Target specific responses of layer 6b (L6b) neurons in the mouse medial prefrontal cortex (mPFC) upon fear memory retrieval', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

One of the fundamental challenges in neuroscience research is to understand how diverse sensory inputs leading to the specific behavioral outcome and what are the networks underlie eliciting such behaviors. This question may only be answered when measurements of structural and functional properties of individual neurons are integrated into a coherent framework, which would then allow numerically simulate (in silico) different networks to predict possible behavioral outcomes. The ‘building block’ for a network model relies on anatomical and physiological data such as neuron input, neuron output, and physiological properties collected from animal experiments. The input can be determined by reconstructing dendrites, functional properties of the neuron can be estimated by obtaining electrophysiological measurements, and output can be determined by reconstructing by their 3D axon branching pattern. Current proposed project work will address some of the building blocks such as projection targets of single neurons upon a specific behavioral expression and their presynaptic partners that are responsible for eliciting such behaviors. Specifically, I will investigate the electrophysiological properties and anatomical connectivity of L6 neurons (L6b) of the medial prefrontal cortex (mPFC) using state-of-the-art techniques and tools such as modified rabies virus labeling and neuron tracing, DREADD technology and optogenetics in a transgenic mouse line that selectively expresses Cre-recombinase in a subpopulation of layer 6b neurons. Exploring mPFC neural circuits may not only provide more in-depth insight on to its involvement in cognitive behaviors but also in a variety of psychiatric conditions such as post-traumatic stress disorders (PTSD). The outcome of this study will establi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'NonLinear Optics for Photovoltaics' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The Shockley Queisser limits the efficiency of single junction solar cells and sets the maximum efficiency for Si solar cells at about 30%. The limit is imposed because of two constraints. First, the energy a solar cell generates from each conversion event is approximately maximized by its bandgap, irrespective of the incoming photon energy. Thus, energetic photons lose most of their energy to heat in the solar cell. Second, a solar cell cannot harness photons at wavelengths longer than its bandgap. Therefore, splitting of energetic photon to two Near-IR (NIR) photons doubles the quantum efficiency and the output energy a PV delivers. Also the fusion of two NIR photons below the bandgap of PV to generate one photons accessible for the PV (energy above the PVs bandgap) bust the potential efficiency of PV above Shockley Queisser limit.Nonlinear optics (NLO) offers efficient frequency conversion. Yet, it cannot contribute to PVs due to operation limits at high intensity and coherence, much above the solar radiation. Solar powered lasers allows to increase intensity and coherence by orders of magnitude, thus it is the missing link between PVs and NLO. But thus far, power threshold of solar laser is above 2000 suns , making it inapplicable for PVs. Here I propose to build solar powered laser at low solar concentration (below 2 suns), which will open the field of NLO for PVs. This proposal is based on my recent experimental demonstration , which enables the reduction of current power threshold of incoherently pumped laser by three orders of magnitude. In addition to PVs, this research opens the way to new high power lasers, and many on-chip applications in spectroscopy, sensing, and communication.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Exploring the role of the mitochondrial alternative respiration in carotenoid biosynthesis during tomato fruit ripening' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Tomato is one of the most economically relevant crops in the world and is the main model system for fruit ripening studies at biochemical, genetic and molecular levels. In this climacteric fruit, a sudden increase in respiration takes place at the onset of ripening, usually in concert with increased production of ethylene that eventually impacts fruit color, firmness, taste, and flavor. During ripening, tomato accumulates high contents of health-promoting carotenoids (pro-vitamin A, antioxidants), which require a high production of carbon precursors and ATP. In this respect, both mitochondrial and chromoplast respiration have been proposed to play important roles in fruit ripening and carotenoid metabolism. The general aim of this project is to determine the contribution of mitochondrial respiration to the supply of energy and carbon for the production of carotenoids in tomato fruit during ripening. In particular, we will perform metabolomics of genetically modified tomatoes with altered mitochondrial and chromoplast respiration at different ripening stages. Furthermore, 13C- and 14C-labelling experiments will be performed to trace the fate of carbon from primary to secondary metabolites. In parallel, we will measure the relative glycolytic and TCA cycle fluxes and, for the first time in tomato, the in vivo activities of mitochondrial electron transport chain pathways by using the 18O fractionation technique. Combining these data with the analysis of transcript and protein levels of the main components of respiratory and carotenoid pathways and mathematical modelling will unveil novel metabolic checkpoints and connections between primary and secondary metabolism during fruit ripening. The generated new insights should contribute to the implementation of new biotechnolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exploration of the biosynthetic potential of the secondary metabolome of the newly identified fungal endophyte Cyanodermella asteris' (CyanoAsterisMETAB).

assistant: **Innovation**

In the proposed research I aim to explore the secondary metabolome of the newly identified fungal endophyte Cyanodermella asteris. In this regard, we have selected two in silico-predicted polyketide synthase gene clusters, which will be further examined. The selected gene clusters thereof are chosen for vector construction in Escherichia coli and subsequently the heterologous expression in fungal hosts (Aspergillus niger or Aspergillus nidulans) will be performed. Afterwards, the engineered expression strains will be examined in a combined effort applying mass spectrometry and nuclear magnetic resonance experiments to identify the newly produced compounds. Additional metabolomics-based tools and molecular networking will be employed. Moreover, the biosynthetic pathways of the isolated natural products of the respective gene clusters will be fully delineated.


**Keywords:** Cyanodermella asteris, fungal endophytes, heterologous expression, natural products, biosynthesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Institutions, Policy and Culture in the Development Process' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project aims at developing theoretical and empirical research on the structural transformation that accompanies economic development and on the determinants of its success or failure. This transformation involves changes in policies, institutions, and even preferences and social hierarchies. The project consists of four subprojects. Since China represents the most spectacular ongoing episode of economic transition, four of them focus on the Chinese experience, while the remaining ones address general issues in growth and development. The first subproject analyses some puzzling features of China's recent growth experience, such as the coexistence of high growth with increasing capital export, and the falling labour share, with the aid of a theory which emphasises the efficiency gains associated with the reallocation between firms of different productivity. Since changes in income distribution are an important element, and a concern, of the Chinese transition, the three following subprojects focus, respectively, on the crisis of the system of old age insurance, the effects of the rise of the middle class, and the introduction of special economic zones in the 1980s. Two subprojects study different aspects of competition policy in development. The first one focuses on intellectual property right protection, emphasising the link between innovation, technology adoption and human capital accumulation. The second one studies the coordinating role of industrial policy and how its scope changes with development. The last two subprojects focus on culture. The diffusion of preferences and values that foster cooperation rather than conflict is no less important than incentives for technology adoption. Likewise, the rise of an entrepreneurial spirit" is an engine of growth in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reducing diagnosis and treatment risks by leveraging knowledge and practices of health care professionals' (RIGHT).

assistant: **Innovation**

Risks in diagnosis and treatment are one of the most important problems in the care management at any level of care also in new Member States. Right project will provide a semantics-based healthcare information infrastructure, to seamlessly integrate services and information, that, through a proper level of care Knowledge Management and a Decision Support System, will support knowledge driven collaborative practices in Networks of Health Care Professionals of new member States, in order to minimise medical errors in diagnosis and treatment.To achieve this objective has been essential to constitute a Consortium gathering technical and scientific partners, users and multipliers coming from across the Europe and in particular from the new member States allowing the necessary integration of the research effort in ICT in an enlarged Union. Pursuing its aim, the project will first of all contribute to build enlarged Europe in a field, as HC, fundamental for the future of the EU 25, for its social integration and in which all Member States, and particularly new ones, are active.Right will develop a KM system integrated with Electronic Healthcare Record systems that will be used by the new Members States HCPs in dealing with their daily tasks. The HCP could rely on a platform that will offer a complete access to information and possibility of sharing knowledge with all the levels of care. Will be provided also a DSS (based on clinical guidelines issued by medical authorities) for HCP and medical students.To provide meta search functionality and retrieve information from multiple, distributed content sources in parallel, the solution foresee a Semantic Information Retrieval module with an ontology management system able to 'translate' the user's intention (natural language input
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'G4 DNA-Based Conducting Wires' (G4DNA) under Fifth Framework.

assistant: **Objectives**

G4-DNA is a stable linear DNA molecule made of consecutive planes of 4 guanine (G) bases connected with 4 poly-G strands. The aim of this project is to produce a novel G4-DNA wire with and without metal ions in the internal cores of G tetraplexes. A linear arrangement of redox-active ions in the centre line of the molecule will lead to the formation of a molecular wire by means of electron transfer or transport. The ability to incorporate metal ions with different contributions to the conduction properties into a single G4-DNA wire will enable the construction of wires composed of segments with high and low resistance regions along the conductor. The electrical transport properties of single G4-DNA wires will be studied by scanning tunnelling microscopy and spectroscopy and the conductivity along single G4-DNA molecules will be monitored by direct electrical transport measurements between metal nano-electrodes. The development of such molecular wires and devices may lay a basis for DNA-based Nano-electronics.OBJECTIVESThe objective of this proposal is to develop G4-DNA-based nano-electronics. G4-DNA is a four-stranded structure that contains a planar arrangement of four guanine (G) nucleotides. We will produce conducting organic wires based on complexes of G4-DNA and also G4-DNA with metal-ions in the central space of each G4 plane. Electrical transport through single G4-DNA wires of different length and metal composition will be measured. Electronic conductivity of G4-DNA based wires will be altered by changing the nature of metal ions in the wire and the average distance between the neighbouring metal ions.DESCRIPTION OF WORKG4-DNA with and without different metal-ions will be prepared. The G4-DNA molecules will be deposited and attached to a metal surface. Scanning t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'TAPPING POTENTIAL ENERGY FROM NATURAL GAS INVOLVING PREHEATING THE GAS BEFORE EXPANSION USING A COGENERATING PLANT' to be submitted under Fourth Framework.

assistant: **Abstract**

This plant is designed to recover potential energy from natural gas used at the CARMEUSE Aisemont works (Province de Namur, Belgique), and to convert this energy into electricity using a 260 kW turbo-generator. Furthermore, in order to preheat the gas before expansion at 93°C, 4400 kW co-generating unit is added to the turbo-generator.L%Annual electricity output : Operating annually for at least 8000 hours, the output generated is :Pn = 650 KWE = 5.200.000 kWhThe net specific consumption = 6000 kJ/kWhPrimary energy savings using the recovery plant: compared to a conventional thermal plant with an average output of 38% specific consumption of : 18.200 Gj/YReduced Polluting emissions using the recovery plant :SO2 : 9100 kg/yCO2 : 1.365.000 kg/yNOx : 3276 kg/yThe originality of this type of plant which in terms of Belgium industry, is virtually non-existent, resides in its small dimensions and nominal use of 8000 hours a year. The innovative aspect also turns on the choice and association of components, i.e.:- a high speed (around 30000 rpm) expansion turbine with turbo-rotor mounted on a magnetic bearing and generator linked to a frequency converter reducing the frequency from 1.100 Hz to 50 Hz. The turbine does not involve maintenance costs (no oil) and has a long service life.- for pre-heating the gas, the choice of a 400 kW co-generating as opposed to a more heat production unit, offering greater operating benefits, primary energy savings and less air pollution.