RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'LITEBUS-MODULAR LIGHTWEIGHT SANDWICH BUS CONCEPT'.

assistant: **Innovation**

Increasing awareness by the public opinion about environmental issues, energy and material conservation at all stages of product life (from raw materials to disposal/recycling) is putting the industry in general and the transport industry in particular under increased pressure to reduce CO2 emissions and save energy. Environmental protection and safety will be increasingly influenced by legislation.The European transport industry is estimated to generate 22% of the carbon dioxide emission. As the car population is expected to grow 40% by the year 2010 new tough targets for reducing emissions by 30% in 2010 are being set by the EU, against the state of the art technologies of 1995. It is generally agreed by the industry that reductions of this size will require a change in current technologies. Multimaterial technology (sandwich and/or hybrid materials) is becoming increasingly important in new vehicle design. Public service vehicles (buses and coaches) are regarded as primary targets for application of sandwich construction and multimaterials. Public service vehicles (PSV) play a major role in the transportation industry of both industrialized and developing countries. The proposed project will be focused on the development of a novel technology to manufacture bus/coach bodies using sandwich multimaterial panels. The main overall objectives of the project are:- Solving the problem of reducing weight and production costs of land transport vehicles through the development of a technology of modular bus/coach construction, using ?all composite? multimaterial sandwich panels instead of steel/aluminium spaceframe lined with sheets of different materials.- Devise design methodologies that reduce production lead time through reduction of number of components, functional integr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Testability of Analog Macrocells Embedded into System-on-Chip' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

TAMES-2 addresses the problem of industrial testability of mixed signal interface macrocells containing data converters embedded in SoC. To focus on the main industrial requirements, e.g. improving the test quality while reducing test costs, a reusable DfT methodology will be defined, by introducing the key concepts of test reuse at SoC, architectural and circuit level. Innovative DfT techniques will be implemented in two IP blocks that have complementary test challenges. The methodology will be validated through the design of testchips containing the IP blocks. A rating methodology will be applied during testchips characterization to check the objectives achievement. Exploitation within TAMES-2 will be biased towards marketing the IP blocks embedding advanced DfT solutions, towards the dissemination through international conferences and academic courses, and the submission of the results to standardisation organisations.Objectives:The objective of the TAMES-2 project is to improve the industrial testability of high-resolution analogue to digital interfaces embedded in SoC (System-on-Chip).The work will respond to three key industrial demands:- Test cost reduction through minimisation of test time and test development cost;- Improvements in test coverage and outgoing quality, to address the industrial trend for higher quality product at lower cost;- development of test reuse concepts and integration of the associated advances in test engineering into the design flow for new interface designs in SoC applications.TAMES-2 will improve mixed-signal test engineering as it will characterise test solutions at the SoC, architectural and circuit levels, develop reusable test solutions in the mixed signal domain, and push the sate-of-the-art in high-resolution embedded converters
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Boat Hulls with Enhanced Performance' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

This ambitious project aims to develop new environmentally friendly manufacturing processes for the production of lightweight thermoplastic composite structural vehicles (ie semi-trailers), vessels (ie boat hulls) and components at lower cost, with enhance d performance and inherent recyclability.  The new manufacturing processes involve developing (i) low melting point and low viscosity thermoplastic polymer oligomers (containing no volatile organic or hazardous chemicals) that are capable of being moulded t o form high fibre content (ie 50% by volume) structures necessary to achieve high mechanical performance and thus to reduce weight, fuel use and CO2 emissions;  (ii) techniques to polymerise the oligomers in the mould to form large surface area thick sectio ned thermoplastic composite structures with excellent mechanical properties, inherent corrosion resistance and conformance with end of life recycling directives and;  (iii) recycling strategies and methodologies for thermoplastic composite structures.  The p roject then aims to develop and demonstrate the manufacture of  (i) an aerodynamically profiled 13.6 m flat bed semi-trailer with a 25% weight saving over an equivalent steel chassis and;  (ii) an 8 m boat hull with a 10% weight saving and significantly enhanced impact resistance over conventional boats made in glass fibre reinforced polyester resins. If successful, this project would enable European companies to manufacture lightweight, corrosion resistant vehicles and vessels using an environmentally friend ly process (ie no VOC emissions) and materials that are inherently recyclable. This would not only increase the competitiveness of Europe but have a number of major social benefits (ie vastly reduced CO2 emissions, fuel savings, reduced landfill etc).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Central European Advanced Therapy and Immunotherapy Centre'.

assistant: **Objectives**

Progress in biomedical science enables scientists to use a whole new toolbox to treat significant groups of diseases, such as inherited rare diseases or diverse rare cancers. Advanced therapy medicinal products (ATMPs) apply recent advances in genomics, cell biology and/or gene editing to deliver truly personalized curative options. The project proposes to establish flagship ATMP-focused facility on the margin of academia and clinics: Central European Advanced Therapy and Immunotherapy Centre (CREATIC) at the Masaryk University (MU) in Brno, Czech Republic. MU will team up with the leading European research institutions: (1) Fraunhofer Institute for Cell Therapy and Immunology IZI, (2) Leipzig University, which together forms a significant cluster of research excellence in research, development and training in the fields of gene and cell therapies and (3) Copenhagen University with unique expertise in biomedical innovation law, intellectual property, biomedical ethics, privacy and regulatory framework, and health technology assessment.  Combining STM and SSH disciplines the project will allow for (i) fundamental expansion of the scope of the R&I activities of all partners to build multidisciplinary excellence facilitating the delivery of ATMPs to patients who need them; (ii) establishment of the high level of decision-making autonomy for the CREATIC, which will allow significant organizational and management changes creating spirit and conditions for cutting-edge research and innovation in the Centre, and (iii) strengthen the smart specialization of the Czech Republic (RIS3 CZ 2021-2027) in the domain of Advanced medicine and drugs through the involvement of actors from the academic, public, private and societal sector. Our approach reflects research priorities and soci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Untying the knot of creep and fatigue behaviour of UHPC for sustainable design of infrastructures enabling the carbon neutrality transition' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Concrete, as the most widely used construction material, is responsible for about 7% of global energy-related CO2 emissions. Addressing this environmental challenge within the construction sector necessitates urgent development and adoption of multi-beneficial materials characterized by low carbon emissions, superior durability, and excellent mechanical properties. Ultra-high-performance concrete (UHPC) emerges as such a material, offering a 26% reduction in carbon emissions and a 24% cost advantage according to comparative LCA and LCC analysis on benchmark structures. UHPC is the ideal candidate material for broad application, particularly in construction of new and retrofitting existing aging infrastructure subjected to cyclic and sustained actions, including bridges, tunnel linings, wind turbine towers, roads, and aircraft runways.However, the lack of knowledge regarding UHPC's long-term performance, including creep and fatigue behaviour, hinders its widespread use in infrastructure projects. The objective of this project is to unlock this critical knowledge gap and develop structural design guidelines aimed at driving the construction sector's transition towards carbon neutrality through the use of high-performance materials that enable us to build better, for longer and employing lower material volumes, which all imply reduced consumption of raw resources and reduced environmental impacts in the short and long term. Employing multiscale experimental tests, multi-physics and mesoscale numerical methods, the project aims to comprehensively characterize and predict UHPC's response to creep and fatigue, and the creep-fatigue coupled effect (cyclic creep).InCreeGuIng's breakthrough will fill the current knowledge gaps in understanding UHPC's long-term performance. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Design, study and development of novel functional hybrid nanomaterials, which consist of a nanoparticle core and an unconventional shell of coordination entities with synergetic properties.""'.

assistant: **Concept**

In many strategic research areas, particularly in electronics and medicine, nanochemistry-based technologies have recently grown considerably owing to the specific properties of the nanoscale (e.g. room temperature superparamagnetism, quantum effects), which are hardly accessible by traditional chemical approaches. In this context, most of the actual research carried out on nanomaterials is looking at functionalizing the surface of nano-objects with selective organic / bioorganic entities to implement and tailor the resulting properties and applied perspectives. In contrast, the consideration of coordination entities, such as transition-metal complexes, on the surface of nano-objects is hitherto rather limited and remains to be investigated in a systematic way. The NANOCOORD project is tackling this purpose with a distinct and unexplored approach of associating coordination entities (CE) to the outer surface of inorganic nanoparticles (NP). Therefore, the proposed strategy is paving the way to specific and remarkable properties such as magnetic bistability or photo-dynamic therapy while enlarging the applications panel. The particular knowledge gap in this research area legitimates the development of the project that visions to exploit the distinctive attributes of nanochemistry and coordination chemistry to design innovative functional materials with complementary properties. In light of the numerous potential applications, it is crucial to stress that this multidisciplinary project does not claim to cover all the possibilities but aims at a more methodical exploration of such NP@CE heterostructures, via a judicious and initially restricted selection of two application fields of high impact: combination therapy and data storage. The potential outcomes are highly releva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ionic liquid based Lithium batteries' (ILLIBATT) targeting Sixth Framework.

assistant: **Abstract**

ILLIBATT aims to develop safer and better performing Li batteries that make use of solid-state electrolytes, containing non-volatile and thermally stable ionic liquids, new nanostructured anodes and advanced cathodes. These newly developed materials are expected to be useful in a wide range of different cell sizes: from small, e.g. micro-batteries, to large, e.g. delocalised storage units (10-20kWh).ILLIBATT has 4 key objectives:(i) development of a green and safe solid-state electrolyte chemistry bas ed on ionic liquids and unique ionic liquid based composites;(ii) use of novel nano-structured high capacity anodes, prepared with the help of novel ionic liquids;(iii) investigation of electrolyte properties and the specific interactions of these electrolytes with advanced commercial and self-prepared electrode materials with the goal to understand and improve the electrode and electrolyte properties and thus their interactions; and(iv) construction of rechargeable lithium cells with optimised elect rode and electrolyte components.Accordingly, ILLIBATT aims to overcome the well-known technical problems of the present rechargeable lithium battery technology with the goal to:1- perform breakthrough work to position Europe as a leader in the developing field of high energy and environmentally benign and safe batteries and to maintain the leadership in the field of Ionic Liquids;2- develop appropriate solid electrolytes and nanostructured electrode materials which combination allows to realize true solid state lithium batteries;3- develop all-solid-state prototype batteries operating at room temperature with (4-6):4- specific energy higher than 180Wh/kg with respect to the overall weight of the prototype;5- coulombic efficiency in average higher than 99% during cycling;6- cyc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Janissaries in Ottoman Port-Cities: Muslim Financial and Political Networks in the Early Modern Mediterranean' (JANET).

assistant: **Innovation**

JaNet investigates the economic and sociopolitical role of the Janissaries in the 18th and early 19th centuries through their examination as a complex of interconnected networks in the ‘extended Mediterranean’ (including major Black Sea and Danubian ports). By studying the Janissary corps, the project brings forward a radically new historical analysis concerning, on the one hand, the role of Muslims in the Ottoman and wider Mediterranean commercial economy – a role largely ignored by the bibliography – and, on the other, the processes that led to the creation of diasporas and the dissemination of people and ideas among various Muslim communities in the area.According to our thesis, in the period under examination, the Janissary corps became one of the main channels for the participation of various Muslim social strata of the Ottoman periphery in the Empire’s developing credit market and commercial life, as well as a gateway for their involvement in local and imperial politics. Moreover, it became a platform for the exchange of people, goods, and ideas between different localities covering a vast geographical area. When examined from a Mediterranean perspective, this view allows us to look beyond the information provided by Europe-centered sources and to drastically redefine the sociopolitical and financial role of Muslims in the area, an approach which historical analysis sorely lacks.The project uses a comparative approach to examine a large number of port-cities in North Africa, Egypt, the Aegean, the Adriatic, the Danube, and the Black Sea. The research team – composed of the PI, three senior researchers, five post-doctoral fellows, and two PhD candidates – will study a variety of unpublished sources in Ottoman Turkish, Arabic, Greek, Russian, French, and English. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Mechanisms underlying hemogenic induction in human fibrobalsts'.

assistant: **Objectives**

Hematopoietic Stem Cell (HSC) transplantation whether from bone marrow, mobilized peripheral blood or cord blood is the best example of regenerative cell therapy. HSCs have remarkable therapeutic applications in a broad range of diseases that affect the blood forming and immune system. Nevertheless, there remains a shortage of usable genetically-matched material for all needs. Growing HSCs in vitro from adult or fetal sources or generating them from embryonic stem cells has proven to be challenging despite of 20 years of intensive research. An alternative approach would be to generate transplantable HSCs directly from patients own adult cells using programming technology. We have recently demonstrated the direct induction of mouse fibroblasts into hematopoietic progenitor cells using a combination of four transcription factors (TFs). This induction progress through an endothelial-like intermediate cell. We now have strong evidence that the same blood forming process can be induced in human skin-derived fibroblasts with a similar set of TFs. We first propose to characterize the human induction process using cell surface phenotypes, global gene expression analyses and functional assays. We further propose to dissect the molecular mechanisms of such induction by the identified group of TFs. Specifically, we will investigate the mechanisms that mediate this process by studying how these factors modify the epigenome and therefore directing and establishing a new cell identity. We propose to map TF binding, DNA methylation and histone modifications at a genome-wide level during the induction process. The dissection of such molecular mechanisms may ultimately allow for the use of programmed cells in the clinic. The successful generation of directly programmed HSCs will have a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Novel strategic approach to design better vaccines'.

assistant: **Objectives**

The structure and thermodynamic properties of Y. pestis capsular Caf1 antigen were studied to explain the failure of this protein to induce the cellular immune response. During the assembling of the Caf1 capsule, the collapse of Caf1 hydrophobic core results in the formation of extremely stable Caf1 fibers. This increases resistance of the Caf1 antigen to processing in macrophages and thereby abolishes the cellular immune response. Destabilization of Caf1 by heating caused a shift toward presentation by mature MHC class II. These new breakthrough findings render bases to overcome the self-protection mechanisms of the plague disease and develop effective vaccines. The essence of our approach is to make selected point mutations which do not change the overall 3D structure of the antigen but decreases its resistance to proteolytic processing inside macrophages. This results in the increase of the efficacy of presentation of CD4 T cell epitopes of antigens by macrophages to T cells while specificity of the generated antibodies will not essentially change. We have preliminary proved this theory by using such artificially designed Caf1 monomers. We forecast that knowledge-based engineered antigens will be the basis of plague vaccines of next generation. We have available molecular tools ready to explore in more detail the theoretical basis of engineered Caf1 antigen in a short time. Next we will show the applicability of the theory by developing experimental generic anti-Salmonella vaccine composed of the conservative SefD and SafD putative invasion subunits common for the main virulent strains of Salmonella spp. We strongly believe that our approach is the cutting-edge innovation to combat against dangerous pathogens in general. According to the proposal Prof. Zaviyalov is i