RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Emerging multifactorial complexity at the geminivirus-host interface' (GemOmics) under Horizon Europe.

assistant: **Objectives**

Viruses manipulate their host cells to replicate and spread. This manipulation is based on the activity of virus-encoded proteins, limited due to restrictions in genome size imposed by the viral cycle. How the action of these few proteins results in the massive cell reprogramming observed during the infection remains enigmatic. Geminiviruses are plant viruses causing diseases in crops worldwide. Recent results obtained in our lab using the geminivirus Tomato yellow leaf curl virus (TYLCV) indicate that the proteome of this species, so far believed to encompass 6 proteins, is far more complex than anticipated: the TYLCV genome contains additional open reading frames expressed during the infection and giving rise to new proteins, and viral transcripts are spliced and generate new protein variants. Therefore, the number of viral proteins exceeds double that previously accepted. In addition, we have found that this higher complexity is further increased by the association of viral proteins in an intricate network of intra-viral interactions, which enable novel protein localization and function, leading to an expansion of their interactome and functional spaces. Our results imply that, to get a complete overview of the molecular and functional landscape of plant-geminivirus interactions, the strategies traditionally used, based on the analysis of a limited number of viral proteins in isolation, need to be revisited. Here, we propose to apply a combination of genomic, interactomic, and functional approaches to generate a comprehensive map of the virus/host cell intersection with unprecedented resolution. We will perform a comparative analysis of different geminivirus species, and translate these emerging concepts to independently evolved viral families. The conceptual and pra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Effects of Antiretrovirals for HIV on African health systems, Maternal and Child health (ARVMAC)' (ARVMAC).

assistant: **Innovation**

Increasing access to antiretroviral treatment (ART) in resource-poor settings is an obvious emergency but scale-up of ART poses serious challenges to the overall health system s functioning. The response of the system to these challenges may jeopardize or strengthen its response to other health priorities and will affect the feasibility of MDG 4 and 5 in Sub-Saharan Africa (SSA). HIV is inherently linked to child survival, gender inequities and reproductive health. It increases infant and child mortality wi th up to 40%. Women are 4-25 times more vulnerable to HIV transmission, on average 10 years younger than men when infected and make up the majority of people living with HIV in SSA. Donor investment in vertical ART programs equals a doubling of the current health budget in some SSA countries, thus, access is no longer constrained by drug costs. Low absorption capacity, lack of infrastructure and human resources are the major challenges to implementing the WHO 3 by 5 . Using Tanzania as an example, a redist ribution of 35-70% of the health workforce is required to increase the number on ART from 8,000 to 220,000 in 2005. Lack of integration of ART with antenatal care limits access to prevention of mother-to child transmission. Pooling of staff to ART undermin es the quality of basic care (ANC, IMCI) and reduces access to 2nd level care (e.g. caesarean section) risking to increase child and maternal mortality. How to absorb ART funds, prioritize among different types of care, correctly distribute, monitor and su stain ART in fragile health systems with weak resource allocation capacity, without harming the most vulnerable needs to be solved. We will study health policy, health services and maternal and child health consequences of ART scale-up in population-based setti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'RE-SAMPLE'.

assistant: **Objectives**

Multi-morbid complex chronic conditions (CCCs) are highly prevalent in patients with Chronic Obstructive Pulmonary Disease (COPD). As they have common risk factors and overlapping symptoms, this easily leads to delay of appropriate treatment. Timely and preventive care is essential, as exacerbations of COPD and CCCs are detrimental to patient, health and social outcomes. RE-SAMPLE will take a giant leap in the field of CCC disease management building upon and going beyond existing initiatives, towards evidence-based, inclusive, preventive care and targeted treatment, enabling to “treat a person, not the disease(s)”. RE-SAMPLE will create a knowledge base of multimodal data from health records, clinical studies, expert and patient knowledge and guidelines, and extend this with state-of-the-art Real World Data collection. Predictive modelling through privacy-preserving Artificial Intelligence (AI), will increase the understanding of CCCs including the interdependence of multi-morbidities, and evidence in effective interventions for CCC disease management. The inclusive design and citizen science approach, provides us with credible and accepted RWD tools and a patient-centred eHealth “companionship programme”. GDPR-compliance is carefully integrated from the beginning, and our platform allows for a strong advancement in secure algorithms using multi-party computation. Our AI approach enables statistical validation following clinical standards and useful explanations to build up clinical evidence and trust by the users. As such RE-SAMPLE will act upon the need for diversified, personalized care to alleviate the overall societal and economic burden of these CCCs. The RE-SAMPLE project significantly impact towards this direction not only through the development of the platfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Mothers, grandmothers and the evolution of prolonged lifespan in humans'.

assistant: **Objectives**

I propose a novel evolutionary approach for studying ecological and demographic factors that affect senescence and lifespan in humans. Women are unique among animals due to menopause and a prolonged lifespan after last birth. Evolutionarily, the quest of everyone is to maximise grandchildren numbers. Hence, human women life-history is enigmatic. One possibility is that older women increase their fitness by directing resources to already produced offspring rather than having more. Thus, although women gain most grandchildren from own reproduction, they also gain more by helping offspring. This has fascinating implications. All animals must split their energy between reproduction vs. self-maintenance. Most continue to reproduce until death and produce maximum grandchildren by optimising investment between current vs. future reproduction. Human women must also optimise investment between mothering and grandmothering. How this is done and affected by ecological, social and demographic factors is unknown, but is essential to understanding the ecological and genetic basis of reproduction, senescence and lifespan. My project has 5 aims: 1. How does reproductive effort affect reproductive and post-reproductive senescence? 2. What proportion of grandchildren is gained post-menopause and how is this modified? 3. Is there heritable variation in life-history traits and their senescence, and how do genetic correlations affect evolution? 4. How do patterns of fitness acquisition account for menopause, prolonged post-reproductive lifespan and age of death in humans? 5. How does fitness maximization differ between men and women and affect their lifespans? The questions will be answered using unique data on three generations of individuals that lived before healthcare and modern contrac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Genomic tools for bio-monitoring of pollutant coastal impact'.

assistant: **Objectives**

We shall expose two sentinel fish species to a variety of toxic environmental pollutants, and by genomic and proteomic gene expression profiling, determine adaptive responses and adverse health effects, thereby enabling selection of diagnostic biomarker gene products. Two tools will be developed for assessing the health status of coastal and estuarine environments, benefiting dependent communities and permit sustainable industrial development with maximum natural resource protection:(1) fully flexible DNA mini arrays for practically diagnosing adverse health effects and specific chemical toxicants in environments where the identities of the toxic contaminants is unknown and continually changing and,(2) quantitative analytical methods for specific gene products, for temporal trend determination. Their utility will be validated by analysis of fish from a number of polluted environments and inter-comparison with currently available methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Pension reforms and healthy ageing in Italy and Europe: quasi-natural experimental analysis of linked health and pension datasets' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The COVID-19 pandemic has forced many European countries to spend money that they do not have. This is creating unprecedented levels of debt and will inevitably lead to pressure for retrenchment in social welfare, with pensions seen as a key target. While some nations will seek to protect pensions, others will not. How will these pension reforms impact on healthy ageing? Will such reforms pension save money or perversely pass costs onto healthcare and other welfare systems? We propose an ambitious research programme to inform these critical questions. Our proposed research combines analysis of the Surveys on Health, Retirement and Ageing in Europe (SHARE) in 19 EU countries with specific quasi-natural experiment studies of pension reforms increasing pensionable ages (UK 1995 Pension Act and Italy 2011 Fornero Reform) and reducing pension payments (Netherlands 2013 Pension Reductions and Greece Katrougas Law 2016). Additionally the project will create innovative administrative-record linkages in Italian pension and health system data to quantify occupation-specific mortalities and unequal survival times. Overall, it builds on the PI’s strong track-record in evaluating health impacts of austerity and natural experiment research designs. The anticipated findings will test critical ideas about a ‘health-promoting pension system’ and about which occupational groups may merit additional compensation due to lower survival times. It will help inform critical policy debates by revealing the hidden and unanticipated health consequences of pension reforms and associated inequalities.


**Keywords:** Pension, austerity, ageing, mental health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Processes influencing stratospheric ozone studied using satelite data and models' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The Fellowship will permit a student from the Department of Physics in Heraklion, Greece, to study at the University of Oxford, England. This is part of a collaboration between the Atmospheric Physics groups in both universities to study the composition in the stratos- phere, using satellite data from instruments built in Oxford and models developed in Greece and elsewhere. The work will concentrate on the variablity of stratospheric ozone, and also on water vapour and possible relationships between the two. Good data on both has already been obtained from the Oxford ISAMS instrument, which flew on the Upper Atmosphere Research Satellite. Ms Koutoulaki will be registered for an advanced degree at Oxford while holding the Fellowship.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A High-throughput, Functional Imaging Platform to Accelerate Drug Discovery' in the context of a Horizon 2020 call.

assistant: **Objectives**

The aim of this SME Instruments Phase 1 proposal is to perform a feasibility study for the commercialization of Ima-Go, a novel 96-well functional imaging platform for preclinical drug discovery for substances targeting brain diseases.In contrast to state-of-the-art technologies for functional imaging, which either interfere with cellular viability and physiology or provide only a poor spatiotemporal resolution, Ima-Go is label-free, non-invasive and provides readouts of highest quality and resolution. The Ima-Go platform will introduce to the market new biological assays for human cell lines, which cannot be performed by current competing technologies. MaxWell Biosystems AG developed the most advanced functional imaging platform for tracking neuronal activity used in basic neuroscience research. With Ima-Go, MaxWell Biosystem will scale this technology to a throughput required in drug discovery applications. MaxWell Biosystems AG aims to become a world-wide technology leader in the field of advanced functional imaging platforms and modern data analysis solutions, meeting the needs of pharmaceutical companies and contract research organizations to accelerate drug development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synaptic dendritic architecture as a determinant for processing emotional information of opposite value in amygdalar-hippocampal subnetworks' (SynEMO).

assistant: **Innovation**

The ability to form emotional memories of aversive or rewarding stimuli is a crucial ability to determine avoidance or approaching behavior. Recent reports identify specific populations of nThe ability to form emotional memories of aversive or rewarding stimuli is a crucial ability to determine avoidance or approaching behavior. Recent reports identify specific populations of neurons within the basal and lateral nucleus of the amygdala (BLA) and their corresponding projections that are selectively activated during the retrieval of memories of positive or negative valence. Interestingly, BLA neurons projecting to the CA1 area of ventral hippocampus (vCA1) are tuned for either positive or negative predicting cues, suggesting the existence of two distinct pathways routing opposite information to vCA1. How emotional values originating from the BLA are differentially processed by downstream vCA1 neurons remains unclear. An appealing possibility is that vCA1 encodes different valence-related information through distinct spiking patterns and temporal structures. Distinct signal processing in the two BLA-vCA1 pathways might be supported by specific non-linear dendritic input integration, a mechanism that can be promoted by input clustering induced by heterosynaptic plasticity. We hypothesized that an organized synaptic distribution within BLA-vCA1 subnetworks exists, and that local heterosynaptic plasticity determines different temporal structures of neuronal output vCA1 in the processing of negative or positive information. We will use a novel viral-based tracing approach combined with an established assembly-labeling strategy to understand the anatomical input-specific structural organization synapses of different valence-related information along vCA1 dendritic arbour. Then,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High-throughput droplet-based single-cell small RNA sequencing technology' in the context of a Horizon 2020 call.

assistant: **Objectives**

Droplet-based single-cell RNA-sequencing (scRNA-seq) technologies have penetrated almost all branches of life sciences and have significantly advanced our understanding of cellular processes and organism development. However, despite their astonishing impact, most of the scRNA-seq technologies reported to date rely on poly(A) tail capture and thus are mainly restricted to the protein-coding RNAs, while neglecting a substantial proportion of the transcriptome, including small non-coding RNAs. As a result, very little is known about the non-coding RNA expression and function in individual cells, and especially their role in the establishment of cellular phenotypic diversity. Small RNAs contain a variety of classes, of which miRNAs are the most common and these act as regulatory molecules by suppressing translation of mRNAs. In addition, loss-of-function studies of miRNAs uncovered their involvement in development of nearly all tissues, including hematopoiesis. However, most studies exploring miRNA dynamics reported to date relied on bulk cell assays, thus disregarding the individual cell types and their heterogeneity. In the scope of this proposal, we aim to develop a high-throughput droplet-based single-cell small RNA-seq (droplet-small-seq) for simultaneous miRNA and mRNA capture and sequencing. We will apply this newly developed technique to investigate the regulatory roles of miRNAs in cell fate decision during hematopoietic development at a single-cell level.


**Keywords:** miRNA, microfluidics, scRNA-seq, droplet-small-seq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Contested Spatialities of Urban Neoliberalism: Dialogues between Emerging Spaces of Citizenship in Europe and Latin America' in the context of a Seventh Framework call.

assistant: **Objectives**

Neoliberal ideologies applied in city politics can be portrayed as key aspects for the progressive and often conflictive transformations of urban space today. Such transformations do not exclusively apply to the political sphere – neoliberalism has also affected the habits of how people imagine, perceive and appropriate urban spaces in their daily life. Cities play a strategic role in the variegated geographies of neoliberalism, but relatively little research critically assessed the challenges citizenship faces in neoliberal societies. The interdisciplinary exchange programme CONTESTED_CITIES will tackle this gap – it investigates the discourses and practices of contest and re-appropriation of urban space, thus providing a novel understanding of how opposition against neoliberal urban development is being re-framed in the course of the current financial and economic crisis. It will bring together scientists from European and Latin American universities to discuss some of the striking consequences of urban neoliberalism and the resistance originated in different geographical backgrounds. By applying innovative qualitative methodologies such as reflexive photography and other visual accounts, the project aims at providing theoretical advances within citizenship studies and urban geography as well as at producing new empirical insights to the consequences of recent urban policies. Within an interdisciplinary network to analyse and compare urban policies, gentrification and contestation in Europe and Latin America, the exchange programme creates additionally the conditions to introduce policy transfer by learning from Latin American cities - which have experienced for decades urban conflict and highly innovative urban solutions - as laboratories of social change, and to cre