RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'COP21: Results and Implications for Pathways and Policies for Low Emissions European Societies' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The COP21 outcome represents an important new strategic context for EU climate policy. Analysing the implications of this new context requires an interdisciplinary approach, combining analysis of the evolution of the international climate regime as well as of NDCs and their socio-economic implications. Such analysis is also urgent, given the timelines imposed by the Paris Agreement for a “facilitative dialogue” in 2018 with a view to creating the conditions for the revision of NDC in 2020. In order to address the context described above, this project has four objectives : 1) Assess the adequacy of the NDCs submitted at COP21 in light of the global temperature target of limiting warming to 2°C/1.5°C. Through the analysis of GHG scenarios and energy system scenarios , the project will pay particular attention to the concrete system changes induced by NDCs, and compare them with the changes required to meet the global temperature limit. The project will also analyse scenarios limiting warming to 1.5°C, and the impact of NDCs on other sectors. 2) Assess the implications of NDCs and deeper mitigation pathways on other European socio-economic objectives. By integrating GHG and energy system scenarios into a range of different macro-economic, global energy system models and other quantified methodologies, the project will investigate implications for European socio-economic objectives related to innovation and technology deployment; trade and competiveness; investment, financial flows and economic growth (“green growth”); and global energy markets and energy security. 3. Assess the adequacy of the outcomes of COP21, and the implications and opportunities emerging from ongoing UNFCCC negotiations. The project will undertake a social sciences-based (in particular international l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Genetic landscape of the homology search' to be submitted under Horizon 2020.

assistant: **Abstract**

The integrity of genetic information is central to life, yet the DNA is vulnerable to damage from internal and external sources. Incorrect repair of DNA damage drives mutagenesis, loss of genetic information, ageing, and cancer. Double strand DNA breaks (DSBs) are perhaps the most threatening DNA lesions, where the integrity of both strands of the DNA duplex is interrupted at the same position. In E. coli, faithful repair of DSBs is possible only through the homologous recombination (HR) pathway which uses replicated chromosome as a template to recover the information. At the center of HR lies an elusive search process, during which broken strand localises and pairs with the repair template.I will use a combination of CRISPR/dCas9 screening and in-situ genotyping of pooled library of strains to characterise the genetic landscape controlling the homology search. First, I will develop a low probability DSB induction method, to limit the DSB-formation to only a single chromosome per cell. Next, I will design and implement a whole-genome CRISPRi screen coupled to high-throughput sequencing and map the genes involved specifically in the homology directed repair of DSBs. The knowledge of the recombination-specific genes will allow to create a refined, high-quality phenotypic screen. In this screen the whole chromosome dynamics will be monitored and defects in the DNA movements will be characterised for each tested target with a microfluidic-based fluorescent microscopy. Each phenotype will be linked to a specific gene using the state-of-the-art in-situ phenotyping approach called DuMPLING. The functional characterisation of recombination genes will allow to conclude a molecular model of the search process in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'THE CUSTOMISATION/PRE-OPERATIONALISATION OF WATER MANAGEMENT INNOVATIONS FROM SPACE FOR EUROPEAN CLIMATE RESILIENCE', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

PCP-WISE aims to customize/pre-operationalize water management innovations from space for European climate resilience via pre-commercial procurement (PCP). The project, spanning phases from solution design to field validation, targets TRL 8. It addresses water-related crises (floods, fires, infrastructure impacts) using space and Earth Observation data. Objectives include common operational information products, interoperability mechanisms, and an active user network. With climate change impacting water availability and distribution, PCP-WISE seeks to enhance EO-based information for better regional water management, promoting resilience across EU borders. It focuses on local dynamics in water availability and aims to anticipate extreme climate conditions through an integrated water intelligence system. The project's significance lies in its potential to mitigate water-related crises, driven by a unified water taxonomy and Earth observation-based modeling. Through comprehensive research and development solutions, PCP-WISE aims to boost adaptation across the EU, targeting stakeholders in water management, environment, first responders, cities, and agriculture. The project's objectives are designed to adress business, technical, economic, and policy goals. Key results include capacity-building efforts, climate-related inputs, stakeholder engagement, and the dissemination of innovative solutions to advance water resilience both locally and globally.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Personalized priors: How individual differences in internal models explain idiosyncrasies in natural vision' (PEP), addressing dissemination and exploitation.

assistant: **Impact**

In the cognitive and neural sciences, the brain is widely viewed as a predictive system. On this view, the brain conceives the world by comparing sensory inputs to internally generated models of what the world should look like. Despite this emphasis on internal models, their key properties are not well understood. We currently do not know what exactly is contained in our internal models and how these contents vary systematically across individuals. In the absence of suitable methods for assessing the contents of internal models, the predictive brain has essentially remained a black box.Here, we develop a novel approach for opening this black box. Focusing on natural vision, we will use creative drawing methods to characterize internal models. Through the careful analysis of drawings of real-world scenes, we will distill out the contents of individual people’s internal models. These insights will form the basis for a comprehensive cognitive, neural, and computational investigation of natural vision on the individual level: First, we will establish how individual differences in the contents of internal models explain the efficiency of scene vision, on the behavioral and neural levels. Second, we will harness variations in people’s drawings to determine the critical features of internal models that guide scene vision.  Third, we will enrich the currently best deep learning models of vision with information about internal models to obtain computational predictions for individual scene perception. Finally, we will systematically investigate how individual differences in internal models mimic idiosyncrasies in visual and linguistic experience, functional brain architecture, and scene exploration.Our project will illuminate natural vision from a new angle – starting from a cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Embedding RRI in Western Balkan Countries: Enhancement of Self-Sustaining R&I Ecosystems' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Although Western Balkan countries (WBCs) have improved in terms of R&I performance, research and innovation efforts should be further enhanced for bridging the remaining ‘gap’ with the rest European regions. RRI principles can act as enablers for the sustainable development of the local R&I systems, enhancing the effectiveness of R&I strategies contributing to the advancement of Western Balkan socio-economic progress in a transparent, open, and inclusive way through active participation of all quadruple helix actors.WBC-RRI.NET aims to foster the application of RRI principles at the territorial level in five (5) Western Balkan -4 region-level and 1 country-level- R&I ecosystems and promote a multi-level steering R&I governance framework in the WBCs. RRI principles will act as enablers to the shared learning and diffusion of R&I governance innovations at territorial level, enhancing R&I planning, including S3 Strategies in the WBCs.The project’s approach evolving through an analytical, reflective and implementation thread, will operationally address the 5 WB territories (partners represent all parts of the quadruple helix) and subsequently influence the wider WB region, by activating the embedding of RRI into their R&I ecosystems. This will be realised by RRI activities throughout the entire project (horizontal aspect), raising an active dialogue in the wider WB region and fostering the comprehension of all RRI pillars under a holistic framework based on a ‘smart directionality’ approach, offering stakeholder engagement with a focus on citizen participation. Alongside, 5 RRI ‘anchor’ initiatives (vertical aspect), as interventions touching in-depth specific RRI keys, territorial features and scientific domains, will allow RRI principles to be rooted in the territorial ec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TumoR microEnvIronment Normalization FOR enhanCed photodynamic thErapy' in the context of a Horizon Europe call.

assistant: **Objectives**

The progression of cancer is closely associated with alterations in the mechano-cellular phenotype and in the structure and mechanical properties of the tumor microenvironment (TME) in a complex and not well-understood manner. Desmoplasia, a tumour-associated fibrotic reaction, is responsible for tumor stiffening, poses a major barrier to effective drug delivery. Although novel therapeutic strategies that target cancer cells are emerging, their efficacy varies due to intra- and inter-patient variability as well as tumor heterogeneity. Notably, photodynamic therapy (PDT) is gaining prominence as a compelling alternative. This two-stage treatment harnesses both light energy and a specialized drug (photosensitizer, PS) to target cancer cells upon activation by a specific wavelength of light. However, the effectiveness of PDT is greatly compromised by various resistance factors originating from the complex TME. These factors can present several biological barriers, including desmoplasia. In this project, we propose the use of TME normalization treatment with approved anti-fibrotic drugs in combination with PDT. We aim to test the hypothesis that the combination of anti-fibrotic drugs that remodel and normalize the TME with PDT can increase the PDT efficiency. The specific research objectives are focused on breast cancer (BC) and includes in vitro study of the effect of different components of PDT treatment on BC cells, in vivo study of the effectiveness of the combination of PDT with anti-fibrotic treatment in murine BC models and mathematic modelling to optimize the combination therapies. In the proposed project, the fellow will acquire scientific and complementary skills according to his personalized career development plan and through advanced training, international and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Precision medicine in traumatic brain injury using individual neurosteroid response' to be submitted under Horizon 2020.

assistant: **Abstract**

Traumatic brain injury (TBI) is very common and affects 1.8 million Europeans seeking medical help each year. TBI is a major challenge for healthcare providers and poses an enormous economic burden. For decades, TBI has been characterized by severity of symptoms for diagnosis, prognosis, and therapy. However, this classification system is limited since it does not allow to predict long-term outcome after TBI. This state of affairs thus hinders the advancement of TBI research and the development of therapies. The field is thus in dire need of a novel understanding and classification of the individual’s response to brain injury and, most importantly, a fresh perspective on potential targets for effective treatment and prevention of long-term impairment.  My main hypothesis is that brain injury leads to a neurosteroid response with inter-individual variability and that this response is associated with the trajectory of recovery. I further hypothesize, that the most vulnerable patient cohorts, such as adolescent girls, show distinct patterns of neurosteroid response associated with an increased risk for persistent symptoms. NEUROPRECISE proposes a longitudinal cohort study 1) to characterize neurosteroid response with respect to age and sex in children and adolescents with TBI, 2) to evaluate the association of the neuroimaging derived individual injury profile with neurosteroid response, and 3) to explore individual differences in neurosteroid response as a potential target for acute therapy and prevention of chronic symptoms with respect to age and sex in a rodent model.NEUROPRECISE will overcome a critical barrier towards the treatment of TBI by establishing a novel, biological-driven way to stratify TBI patients based on inter-individual differences in the response to T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ECOlogical building enveLOPES: a game-changing design approach for regenerative urban ecosystems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Urbanisation constitutes a major environmental issue of the 21st century. Within cities, densification, the decrease of green open spaces, and a continued reliance on grey infrastructures result in increasing separation of people from nature and decrease access to ecosystem services. This decreases the liveability of cities and reduces human well-being. Current approaches fall short in providing breakthrough solutions, because they perpetuate the human-nature dichotomy due to anthropocentric design. We propose a radical change for city development: instead of minimizing the negative impact of urbanisation on nature, we aim at urbanisation to be planned and designed such that nature – including humans - can co-evolve within the city. This vision requires a radically new integrated ecosystem approach to architecture that focuses equally on humans, plants, animals, and associated organisms such as microbiota. In ECOLOPES, we propose to develop the technology that will allow to achieve this vision. We will focus on the envelope, the building enclosure. In ECOLOPES, we transform the envelope into an ecolope, a multi-species living space for four types of inhabitants, humans, plants, animals, and microbiota. ECOLOPES will develop the core technologies for designing ecolopes in a systematic way, considering the needs of all habitants. ECOLOPES will make biological knowledge available for the architectural design process, to find architectural solutions that enable synergies and limit conflicts between the inhabitants. The ecolopes designed by this multi-species approach will restore the beneficial human - nature relationships in cities. Key products of ECOLOPES are: (1) ECOLOPES Information Model Ontology that integrates ecological and architectural knowledge, data and models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TAPIR-2012', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The Transatlantic Post-Doc Fellowship for International Relations and Security (TAPIR) is a two-year programme for young academics with a background in international relations and international security. The fellows spend a total of 24 months in three different research institutions or think tanks in the United States and Europe in order to build skills in policy-oriented research and create their own networks. Fellows are working with a supervising researcher at the host institute and are integrated into relevant research units or projects there. Host institutes provide office space and overhead costs arising during the fellow’s period of research. The fellows’ research is published by their respective host institutions and/or in adequate academic journals. At the end of each year of the programme, a seminar brings together all fellows so they can exchange information about their experiences and present their research. The circle of participating institutes is composed of thirteen high profile research institutes and think tanks on both sides of the Atlantic as for example the European Union Institute for Security Studies (EUISS), RAND Corporation, Chatham House (Royal Institute of International Affairs), United States Institute of Peace (USIP), and the German Institute for International and Security Affairs/Stiftung Wissenschaft und Politik (SWP). The programme makes a substantial contribution to the creation of international networks and fosters mutual understanding. As highly accomplished academics looking for a career in policy-oriented research and consulting, TAPIR fellows will be able to experience different policy consulting approaches on the job and to forge contacts within the transatlantic policy community. In addition to the exchange of information and reso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Biomimetic Restoration of Tooth Dentin via Deep Mineralization'.

assistant: **Concept**

Dentin hypersensitivity (DH) is a prevalent health condition occurring in more than 50% of the population. Despite the upward trend of risk, there has not been a permanent solution to DH. An ideal treatment should reproduce a well-integrated mineral layer, mimicking the protective cementum tissue that covers exposed tubules and seals tightly by penetrating into them. Such restoration can be accomplished using peptides that epitomize mineralization properties of dental proteins. Proposed herein is the development of a novel approach called Deep Mineralization, that will enable biomimetic restoration of exposed dentin by forming a well-integrated acellular cementum-like protective mineral layer. This will be accomplished via four specific objectives that include: (i) Experimental selection of peptides via directed evolution paired with next-generation sequencing called Deep Directed Evolution to generate peptide datasets (big data); (ii) Development of protein-derived peptides via machine learning (ML) based predictive design platform (Biomineralization Intelligence) that is trained with big data and refined through (iii) High-throughput (HTP) validation assays, and eventually (iv) Establishing a peptide-guided remineralization methodology (Deep Mineralization) by mimicking the remineralization action of saliva in which remineralizing peptides bind to exposed dentin, recruit calcium and phosphate ions and synthesize an integrated acellular cementum-like mineral layer, thereby, restoring tooth’s natural protection. Aligned with the current vision of the EU that aims to adapt methodologies to generate big data and tools to enable fast-track discoveries with healthcare delivery, this study marks the onset of implementing ML and HTP screening methods into dental research. Suc