RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular and genetic analysis of cell polarity, rna localisation and axis formation in the drosophila oocyte' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content Although mRNA localization is a general mechanism for protein targeting in polarised cells, little is known about the molecular events that underlie this process. The Drosophila oocyte provides an excellent system to study this question, because the localisation of three different mRNAs to distinct positions within this cell determines the two body axes of the embryo. Genetic screens for mutants that disrupt axis formation have identified a number of genes that are required for mRNA localisation. These screens could not recover lethal mutations, however, and therefore missed many important components. I propose to perform a genetic screen that overcomes this problem. Firstly, I will use the newly-developed FRT/FLP system to screen for mutants in germline clones, since this permits the recovery of mutations in lethal genes. Secondly, I shall screen for defects in mRNA localisation directly, by visualising the localisation of these RNAs in living oocytes using fluorescently-labelled Staufen protein. The subsequent molecular analysis of these new genes should give insights into the basic mechanisms of mRNA localisation in many cell-types and organisms, since Staufen is highly conserved during evolution and plays a role in mRNA localisation in neuroblasts as well as the oocyte. Training content (objective, benefit and expected impact) The proposed thesis project will give me a wide range of experience in both Drosophila genetics and molecular biology, and will enable me to learn a large number of different techniques. I have chosen to go to the Wellcome/CRC Institute because it is one of the leading Institutes in the field of Developmental Biology in Europe, and Cambridge is a major centre for research on Drosophila. I will be affiliated with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Psilocybin Therapy for Psychological Distress in Palliative Care Patients' (PsyPal) targeting Horizon Europe.

assistant: **Abstract**

Relieving serious health-related suffering for patients in palliative and end-of-life care, be it physical, psychological, social, or spiritual, is a global ethical responsibility. However, the profound psycho-emotional and existential distress entailed by such suffering, despite often being an enormous burden for both patients and their loved ones, remains a field largely overlooked by health care providers and the scientific community. Those people may develop mood or anxiety disorder for which neither non-pharmacological nor pharmacological interventions exist. In this context, we believe it is now time to target these unmet needs in the palliative care population. We want to initiate a paradigm shift at the boundaries between palliative care, psychiatry, psychology, neuroscience, and spiritual care. Our starting point is the preliminary results being reported for administration of psilocybin, the main psychoactive compound of so-called ‘psychedelic mushrooms’, in patients with depression. The objective of our project is thus to examine the clinical effect of a cutting-edge, individualised and patient-centred, open and standardised Psilocybin Therapy, addressing these unmet needs of patients in palliative care. We will show high quality evidence via a multi-centre Randomised Clinical Trial of the value of our therapeutic model in patients (and for the following four conditions: COPD, Atypical Parkinsonian Disorders, ALS, and Multiple Sclerosis), their loved ones and care providers, in a diverse sample of the European population, in addition to better understand the mechanisms of therapeutic change of our model. Finally, our project will establish a sustainable, multi-disciplinary, ecosystem of key European stakeholders jointly contributing to the medical use of psych
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'THE ORGANIC FERTILISER FOR GENUINE, HIGH YIELD PESTICIDE AND CHEMICAL-FREE ORGANIC FARMING' (BIOTA), addressing dissemination and exploitation.

assistant: **Impact**

Chemical fertilisers are still widely used in Europe and across the world despite growing global demand for organic food. The damage caused by chemical fertilisers is often long-term and cumulative - they have a profound negative impact on soil quality while the manufacturing process significantly contributes to climate change. Chemical fertilizers are generally preferred for high-volume, industrial farms in Europe. Many organic and bio-fertilisers are inferior to chemical fertilisers where it matters most: improving yields and cost efficiency. A €5-€10 billion opportunity exists for an organic fertilizer that can address these issues.  With a patented, all-natural manufacturing process, Biota will disrupt the farming industry with an organic fertilizer adapted to all types of farming. Our fertiliser products stimulate plant growth and reinforces disease resistance which eliminates the need for pesticides and other chemical crop protection products. While guaranteeing equal or superior yields to chemical fertilisers, our novel organic method goes a step further than current organic fertilisers by being highly customisable. Biota Nutri BV is a Dutch producer of organic fertilizers founded in 2017, who aims to make organic and healthy vegetables affordable and available to everybody though manufacturing organic liquid fertilizers. We estimated that after 5 years of exploitation, we will achieve €15M in sales and €7M in profit with an ROI of 640%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pumps, electromechanical devices and systems applied to urban water management' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The PEDS 2003 conference to be held in Valencia (Spain) was born with the idea of bringing two worlds together. On one hand, the academic and mechanically oriented perspective of the IAHR, founded in 1935. On the other hand IWA, probably the largest water association in the world; more focused on application and with many members from the water industry.Sustainable water development is becoming every day a more interdisciplinary matter, and one of the clearest examples can be found within the urban context. Two collectives stand out, on one hand, civil engineers, traditionally linked to water and, on the other hand, electromechanical engineers, responsible for most of the elements in the urban water supply and sewerage systems. The PEDS 2003 conference will provide a common framework to share experiences, and approach water management from a wider perspective.A great effort has been done to gather a prestigious and balanced scientific committee that will guarantee the quality of the programme. The main role of this committee will be to referee abstracts for final acceptance as papers. The committee has 27 members from 15 different countries (including 15 members from 6 European Union countries). All of them are renowned Professionals and researchers.GYPSI (Growing and young Professionals Support Initiative)The International Water Association decided to create the GYPSI program during 2001. PEDS 2003 will be the first event in which the GYPSI program will be implemented.The basic idea behind GYPSI is to allow young Professionals to actively participate in international conferences and congresses. Allocating some time in the conference to gypsi" individuals and obtaining funds to cover registration fees and travel expenses accomplish this.The GYPSI program will take form
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Aeroelasticity Control for Transportation And GREen ENergy' to be submitted under Seventh Framework.

assistant: **Abstract**

The project focuses on two closely related engineering topics of importance to the EU economy and its society. The unrelenting increase in the length of modern suspended-span bridges makes them increasingly vulnerable to wind-induced vibrations and instabilities known respectively as buffeting and flutter (several bridge-construction projects with central span in excess of 1000m are currently being built or planned). In much the same way large wind turbines with power outputs in excess of 10MW and blade length well in excess of 100m are currently being investigated. As the blades of these machines increase in length, while also being constructed from lighter and more flexible materials, they too become susceptible to flutter and buffeting. In the case of large offshore wind farms, which may be exposed to highly unsteady aerodynamic loading, buffet suppression is especially important if this power generation means is to become widespread and economically attractive.The central focus of the proposed work is to seek common techniques for the analysis and suppression of wind-induced oscillations in large flexible civil engineering structures. These apparently unrelated systems face similar challenges and a coordinated attack on both appears to be technically well motivated. The application of small aerodynamics devices will be investigated, in order to devise relatively high frequency and robust control systems, which will be both simulated and tested in wind tunnel.The research is highly interdisciplinary, as it combines mechanics, aerodynamics and control.The main beneficiaries of the work will be the bridge design and construction industry as well as the wind turbine industry. Secondary beneficiaries will include government and society at large, who will have access to c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mixing and Angular Momentum tranSport of massIvE stars' to be submitted under Horizon 2020.

assistant: **Abstract**

With the CoRoT & Kepler data analysed, the time is optimal to move from observational asteroseismology to innovative stellar modelling of the steal factories of the Universe. With MAMSIE, we follow the footsteps of helioseismologists some 30 years after them, but this time we shall be developing inversion methods for stellar structure based on gravity-mode oscillations that probe the deep stellar interior. MAMSIE will lead to new models for a variety of single and binary stars with masses between 3 and 30 M⊙ whose space photometry and high-resolution spectroscopy reveal sufficient seismic information on their gravity modes to invert the frequencies and compute the stars’ structure. In contrast to the conventional theoretical approach to stellar evolution, the data-driven approach of MAMSIE will allow us to include angular momentum transport due to internal gravity waves, as well as mixing prescriptions for turbulent entrainment, from coupling of the output of 3D hydrodynamical simulations of these phenomena to specialised seismic observables of relevance for massive stars. Our sample includes slow and fast rotators, with and without a magnetic field, with and without a stellar wind. The new models will be placed in an evolutionary context for optimal assessment of the evolution of internal rotation, angular momentum, and chemical mixing throughout stellar life of massive stars. The output of the stellar modelling will provide fundamentals for all topics in modern astrophysics that rely on massive star models. MAMSIE is overarching and will require a multidisciplinary team led by an expert in gravity-mode oscillations working in close collaboration with a 3D hydrodynamics expert; it will offer a highly competitive environment for PhD and postdoctoral research on the astr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Self-organisation of microbial soil organic matter turnover' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Microbial turnover of soil organic matter (SOM) is key for the terrestrial carbon (C) cycle. Its underlying mechanisms, however, are not fully understood. The role of soil microbes for organic matter turnover has so far been studied mainly from the point of view of microbial physiology, stoichiometry or community composition. I propose to shed new light on it from the perspective of complex systems science.Microbial decomposition of organic matter requires the concerted action of functionally different microbes interacting with each other in a spatially structured environment. From complex systems theory, it is known that interactions among individuals at the microscale can lead to an ‘emergent’ system behavior, or ‘self-organisation’, at the macroscale, which adds a new quality to the system that cannot be derived from the traits of the interacting agents. Importantly, if microbial decomposer systems are self-organised, they may behave in a different way as currently assumed, especially under changing environmental conditions.The aim of this project is thus to investigate i) if microbial decomposition of organic matter is driven by emergent behaviour, and ii) what consequences this has for soil C and nitrogen cycling. Combining state-of-the-art methods from soil biogeochemistry, microbial ecology, and complex systems science I will• Investigate mechanisms of spatial self-organization of microbial decomposer communities by linking microscale observations from experimental microcosms to mathematical, individual-based modelling,  • Elucidate microbial interaction networks across the soil’s microarchitecture by linking microbial community composition, process rates and chemical composition of spatially explicit soil micro-units at an unprecedented small and pertinent scale
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'EUROPEAN SLIMHOLE DRILLING SYSTEM [PHASE 3]' under Fourth Framework.

assistant: **Concept**

Project EUROSLIM I has led to the realization of a complete dedicated slimhole rig, including two dedicated heavy duty drill strings, the rig itself specifically adapted to the drill strings, a special slimhole mud system, a special slimhole monitoring system (in particular for kick control purpose).EUROSLIM II, following EUROSLIM I mainly consisted of real scale tests realized in various geographic and geological conditions according to various drilling programmes. The objective was to demonstrate the capabilities and the limits of the slimhole equipment realized during EUROSLIM I project.The present project is a continuation of the former projects providing* an optimization of the drilling equipment for a more efficient drilling process* a complete formation evaluation with* new core barrels permitting to completely position the core barrels in the space* a set of new wireline tools providing in particular an adequate knowledge of invasion profile, a high vertical resolution together with formation dip information even with non conductive mud.* reliable production equipments permitting the development of marginal fields with acceptable economical conditions.The flow monitoring system has been specified. Some logging tools have been successfully field tested : Array Induction, PhotoDensity, Shallow Focussed Electric, Dual Neutron, and Gamma Ray/Communications. The slim electric submersible pump is ready for the field test.The project has five phases :Phase 1 : Detailed design. All items have come out the research and development stage. So, we have to draw the workshop drawings, together with other manufacturing specifications.Phase 2 : manufacturing/renting/purchasing. Some items will be manufactured internally. Other ones, due to the structure of the partner companies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Effects of early rearing environment on cortical and limbic activity in the rat: validation of an animal model of depression'.

assistant: **Objectives**

Depression is a devastating mental illness associated with extremely high social and economic costs, given that the lifetime prevalence of this debilitating disease can be as high as 15%. Characterized byseveral emotional and cognitive disturbances, this d isease can also be fatal as a significant proportion ofits sufferers commit suicide. Although treatments are available for depression, many of its sufferers do not respond adequately to currently available antidepressant drugs. Furthermore, these drugs oft en have unwanted side effects and the onset of their therapeutic effects can take several weeks, highlighting the need for development of more effective antidepressant drug treatments. When studying mental illness, researchers use animal models to replicat e certain features of a disorder to study its possible biological causes, allowing them to develop specific treatments for the disease. In humans, early life trauma is associated with an increased risk of developing depression in adulthood. Similarly, stud ies in rats indicate that stress in early life leads to later changes in biology and behaviour that resemble symptoms of depression; moreover, some of these changes can be reversed by antidepressant drugs. Recent studies have shown that depressed patients have abnormal activity in brain regions involved in emotion and cognition, that activity in these areas is linked in a complex manner, and that these abnormalities can be ameliorated by successful antidepressant drug treatment. Thus, the current project pr oposes to study, in rats, a) the effects of early life stress on activity in these brain regions, b) the relationship between activity in these different areas, and c) the effects of antidepressant drugs on brain activity after early life stress. These stu di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Flexibility to multisensory contestual information in people with sensory disabilities.' to be submitted under Horizon Europe.

assistant: **Abstract**

One of the brain's main challenges is decoding and integrating information from different sensory modalities to create a coherent perceptual representation. In this perspective, the study of people with sensory disabilities can be considered a model to investigate the mechanisms behind the ability to modify and adapt behavior to external stimuli. When a system is flexible, it can modify itself to gain greater benefit based on environmental conditions. However, when the system does not develop in a typical manner, as in sensory disabilities, it may be less flexible, causing problems beyond perceptual processing and affect aspects of everyday life. Starting with this assumption, FLEX-U unites a novel combination between psychophysics and statistical/modeling analysis to investigate the flexibility/rigidity of the sensory processing mechanisms in people with and without sensory disabilities. The project's main aim will be divided into three specific objectives (SOs). SO1: Understanding of sensory flexibility in the typical individuals; SO2: Modelling of sensory inputs to predict flexible behavior; SO3: Understanding the influence of contextual information on the flexibility of sensory systems in people with sensory impairment and develop rehabilitative training. These objectives will be achieved thanks to the transfer of knowledge between the partner (UNSYD) and the host (IIT) institutions involving advanced expertise in experimental psychology, behavioral modelling, rehabilitative training, as well as solid scientific and clinical collaboration networks. The outcomes of FLUX-U will advance, not only, our knowledge about human perception and multisensory processing at the scientific level, but will help to develop a new rehabilitative training based on multisensory inputs