RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Picometer metrology for light-element nanostructures: making every electron count', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Understanding nanostructures down to the atomic level is the key to optimise the design of advanced materials with revolutionary novel properties. This requires characterisation methods enabling one to quantify atomic structures with high precision.The strong interaction of accelerated electrons with matter makes that transmission electron microscopy is one of the most powerful techniques for this purpose. However, beam damage, induced by the high energy electrons, strongly hampers a detailed interpretation. To overcome this problem, I will usher electron microscopy in a new era of non-destructive picometer metrology. This is an extremely challenging goal in modern technology because of the increasing complexity of nanostructures and the role of light elements such as lithium or hydrogen. Non-destructive picometer metrology will allow us to answer the question: what is the position, composition and bonding of every single atom in a nanomaterial even for light elements?There has been significant progress with electron microscopy to study beam-hard materials. Yet, major problems exist for radiation-sensitive nanostructures because of the lack of physics-based models, detailed statistical analyses, and optimal design of experiments in a self-consistent computational framework. In this project, novel data-driven methods will be combined with the latest experimental capabilities to locate and identify atoms, to detect light elements, to determine the three-dimensional ordering, and to measure the oxidation state from single low-dose recordings. The required electron dose is envisaged to be four orders of magnitude lower than what is nowadays used. In this manner, beam damage will be drastically reduced or even be ruled out completely.The results of my programme will enable p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NK receptors and disease' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

NK cells are relevant to many kinds of disease, including viral infection, autoimmunity, cancer, transplantation and reproduction. The behavior of NK cells is controlled by a large number of different cell surface receptors, in a region on chromosome 19 called the LRC. Some of these receptors, such as KIR, are highly variable in gene number and allele sequence in different individuals. Many of them interact with HLA class I molecules, which are also highly polymorphic. To understand and exploit NK receptors and disease this project has three aims: 1. To investigate how variation in receptors encoded in the LRC influences viral infection and disease course.My laboratory is known for high-throughput KIR copy number and allele typing. Highly polymorphic KIR receptors are refractory to analysis by SNP typing and next generation sequencing (NGS) methods, so interrogation of large numbers of samples for accurate disease determination is not feasible. To overcome this problem we propose to develop digital PCR, sequence-based allele typing, imputation and NGS after sequence capture. Once underway, a large number of disease cohorts and matched controls will be investigated, spanning autoimmunity, infection and birth-weight, in collaboration with other laboratories.  2. To investigate mechanisms viruses use to evade NK cells.To facilitate this we have generated reporter cells that permit weak interaction of receptors with their ligands to be detected by production of Green Fluorescent Protein (GFP). The evasion of NK cells by HCMV, vaccinia and HPV viruses will be studied. This work will be in conjunction with expert virology groups in the UK.3. To identify novel ligands for LRC-encoded receptors.We will use the reporter cells to screen for ligands, initially by blocking binding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multiscale Imaging-through-analysis Methods for Autonomous Patient-specific Simulation Workflows' (ImageToSim) targeting Horizon 2020.

assistant: **Abstract**

Due to the intricate process of transferring diagnostic imaging data into patient-specific models, simulation workflows involving complex physiological geometries largely rely on the manual intervention of specially trained analysts. This constitutes a significant roadblock for a wider adoption of predictive simulation in clinical practice, as the associated cost and response times are incompatible with tight budgets and urgent decision-making. Therefore, a new generation of imaging-through-analysis tools is needed that can be run autonomously in hospitals and medical clinics. The overarching goal of ImageToSim is to make substantial progress towards automation by casting image processing, geometry segmentation and physiology-based simulation into a unifying finite element framework that will overcome the dependence of state-of-the-art procedures on manual intervention. In this context, ImageToSim will fill fundamental technology gaps by developing a series of novel comprehensive variational multiscale methodologies that address robust active contour segmentation, upscaling of voxel-scale parameters, transition of micro- to macro-scale failure and flow through vascular networks of largely varying length scales. Focusing on osteoporotic bone fracture and liver perfusion, ImageToSim will integrate the newly developed techniques into an imaging-through-analysis prototype that will come significantly closer to automated operation than any existing framework. Tested and validated in collaboration with clinicians, it will showcase pathways to new simulation-based clinical protocols in osteoporosis prevention and liver surgery planning. Beyond its technical scope, ImageToSim will help establish a new paradigm for patient-specific simulation research that emphasizes full automa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Digital environment for management of permits and compliance in building and construction' (DigiChecks), addressing dissemination and exploitation.

assistant: **Impact**

DigiChecks proposes to build a digital framework that implements the following steps to overcome the challenges mentioned and pave the way to a more streamlined approach to manage and process permits:Step 1: Standardized Permit Ontology. The first step is to create a shared language for permitting. This language, formalized in a permit ontology, enables the framework to map data from various sources into a common structure and make it processable by a computer in a repeatable manner.Step 2: Digitizing Permit Processes. To deal with the many different actors and their respective processes for permitting, DigiChecks proposes to develop a tool, based on OMG standards, where these actors can model their processes into DigiChecks. These process models can be updated and or removed when the processess change. Step 3: Building Permit Rules. DigiChecks' proposed solution contains the ability for permitting authorities to build their own rules. These rules are used as a base for an automated compliancy checker.Step 4: Integration of the previous steps into a Permit Service (API). To transform the solution into a service, DigiChecks combines steps one (Permit Ontology), two (Permit Process) and three (Permit Rules) into a service offered through an (Open) API. The DigiChecks Permit Service API implements the concepts from the ontology to defined rules and these rules are mapped to a process, thus digitizing the permit workflow. By having an accessible Permit Service, third party developers will be enabled to create new, innovative and reliable permitting applications.The ultimate objective of the solution is to provide flexibility, ease-of-use and efficiency to the permit validation and approval system in the construction project environments. A solution framework is thus require
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A multidisciplinary approach for the computational assembly of large molecular machines from electron density maps' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Proteins are often organized in large, dynamic molecular machines. A mechanistic, atomic-resolution understanding of these machines would provide fundamental insights into the clockwork of the complex machinery underlying human life. However, machines such as the 26S-proteasome have resisted crystallization attempts for decades.Cryo-electron microscopy (cryo-EM) has provided insightful maps of molecular machines, but these lack atomic resolution. In principle, molecular machines can be assembled from atomic homology models of the subunits. However, homology models often contain large errors, causing existing assembly methods to fail.Here I present a multidisciplinary approach for the assembly of large molecular machines from cryo-EM maps. I will combine computational techniques from cryo-EM, homology modelling and interface prediction into ATTRACT, the only docking method that integrates subunit flexibility into the initial search. Driven by a cryo-EM density map, ATTRACT’s coordinated motions will reduce the initial homology model errors, bending the subunits into the correct shape while they are being assembled.The challenging nature of the problem requires the integration of approaches. After firm assessment of the abilities of the method, it will be applied to experimental density maps of the proteasome and other molecular machines, providing new fundamental insights when neither complex nor subunits are known.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'External monitoring of kiln lining condition while in service' in the context of a Fifth Framework call.

assistant: **Objectives**

There is currently unfulfilled requirement for a device that can monitor the condition of cement kiln lingings while in service. This Step 2 proposal is intended to carry out research to produce such a device. Cement kilns are very long thick walled steel cyclindrical structures several metres indiameter. They rotate slowing during operation, reaching very temperatures. To protect the steel from the intense heat, the inside is lined with firebricks. The bricks cna be eroded or material can become accreted to the brick unevenly. Both conditions need to be monitored. At present, the only way to check the kiln lining condition is to stop the process and check manually from the inside - an expensive option. Not knowing the thickness prevents intelligent control of kiln operation. Stopping a kiln before it is really necessary reduces productivity per unit cement produced which increases running costs, increases volume of waste and reduces availability of the kiln which is used to dispose of vehicule tyres and chemical wastes. There is a large number of cement kilns throughout the EU of all of wich could improve productivity by the use of such a device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Activating Learning Paths: Holistic Arts-Based Education and Training for Inclusion and Cultural Awareness' under Horizon Europe.

assistant: **Concept**

ALPHABETICA aims to provide effective solutions that allow children and young people at risk of poverty or social exclusion to access arts and arts-based education through co-creative participatory research actions. For some young people, access to ‘art’ is limited; often understood as a luxury or a leisure activity that may feel inaccessible or irrelevant. For others, their creative endeavours might not be recognised from their own perspective, as being ‘art’. ALPHABETICA will carry out 12 pilot actions across 7 European countries aimed at enhancing the transformative effect of active participation in community-driven artistic co-creation activities. Collectively, the research pilot actions cover a range of school settings and out-of-school community settings with children from 3 to 18, as well as young people and adults of various ages. The project is informed by a synthesis of theories of youth participatory action research, Theory of Change, pedagogies of care, love and enchantment, pedagogies of past, present and the imagined future, and the more-than-human approach. This conceptual framework invites a reflexive and in-depth exploration of children and young people’s complex everyday realities, while offering opportunities for creative self-expression and meaning-making, participation, skills-development, and relationship-building. ALPHABETICA will take a transformative approach by: •providing qualitative and quantitative data on attitudes towards and perceptions of arts by children, families, educators and policymakers,•using participatory and caring approaches and pedagogies to provide an evidence-based assessment of the instrumental outcomes of arts-based education, their transformative impact, and their transferability to children and young people’s other life
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Connectivity Correlate of Molecular Pathology in Neurodegeneration' in the context of a Horizon 2020 call.

assistant: **Objectives**

Neurodegenerative diseases (NDs) are incurable, debilitating conditions, arise mid-late in life, represent an enormous health and socioeconomic burden and no therapies exist. An enigmatic finding in NDs is the early and selective alteration in intrinsic excitability of vulnerable neurons paralleling changes in its circuitry. However, a gap in understanding exists in ND field about the cause of these alterations and whether these modifications regulate degenerative pathomechanisms. Our recent study, examining mechanisms of Purkinje cell (PC) degeneration in Spinocerebellar ataxia type 1 (SCA1) revealed that the earliest cerebellar alterations occur in the major excitatory inputs onto PCs, the climbing fibers (CFs). Based on this, we propose a novel three-step model of neurodegeneration: First, suboptimal functioning of the presynaptic inputs initiates signaling deficits in target PCs. Second, those alterations trigger maladaptive responses such as altered intrinsic PC excitability, thus amplifying pathogenic cascades. Third, at network level progressive dysfunction triggers compensatory synaptic modifications within the cerebellar circuitry. In this proposal, we will test our new hypothesis for NDs on SCA1 and this will be the first study to test circuit-dependency in NDs by selectively silencing presynaptic inputs and examining molecular responses in the postsynaptic neuron. Specifically, we will 1) Identify the dysfunctional CF associated molecular signature in PCs. 2) Elucidate mechanisms involved in altering intrinsic PC excitability. 3) Map the connectome for a structural correlate of the pathology. Using conditional mouse models, pharmacogenetics, transcriptomics, proteomics and connectomics, we will delineate molecular alterations that govern disease from compensa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fibre-based plasmonic micro reactor for flow chemistry' to be submitted under Horizon Europe.

assistant: **Abstract**

Major challenges of the European and worldwide society such as the climate crisis, insufficient environmental protection, food and pharmaceutical shortages, and military aggressions require technologies that substitute fossil fuels with sustainable energy sources in basically all industries. Following the green deal of the EU commission, the European continent shall become the first climate-neutral continent by 2050. The chemical industry is a major contributor to CO2 emissions, as it accounts for about 30% of the industry’s total energy use worldwide. Even though so-called photochemistry promises to sustainably produce chemical compounds by (sun)light, corresponding reactors suffer from insufficient light management, even in modern micro flow reactors, which hinders their upscaling to applications in industry. This is exactly where the key to the technological and economic breakthrough lies, and this is where reaCtor comes into play. It will contribute to the ambitious goal of a sustainable chemistry by developing and validating a novel type of light-driven chemical reactor with enormous scale-up potential for industrial applications. It will be based on an interdisciplinary and innovative technological approach, combining optical fibres for smart light management, metallic nanoparticles as efficient energy transmitters, nano- and micro-fabrication for micro-fluidic functionalization as well as monolithic optical integration, and flow chemistry as an eco-friendly and safe chemical technology. For the first time, a demonstrator of the novel reactor architecture will be set-up and benchmarked with relevant photochemical reactions. Ultimately, the proposed fibre-based microfluidic reactors will enable implementation of new and efficient routes driven by light to prepare p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Wearable technology for the selective detection and continuous monitoring of movement disorders related to Parkinson’s disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Both the diagnosis of PD and the assessment of its time course are essentially clinical and based on performing neurological examinations and simple motor tests. However, these examinations only assess the state of the PD patient’s health throughout the duration of the testing, which is limited in time, and thus fail to detect fluctuations in motor symptoms, which can vary considerably throughout the day and from one day to the next. In order to reduce these disadvantages, Biomedical Lab has developed the PD-Watch, which is a wearable device, configured as a wristwatch, for continuous and long-term monitoring of movement disorders. The information on tremors and other Parkinsonian symptoms are detected via the accelerometer positioned on the wrist and subsequently processed. The value proposition of the PD-Watch is to provide a powerful tool and an innovative solution to identify the best possible treatment specific to each patient that will minimise PD motor symptoms. The PD-Watch has an improved ability to discriminate motor activity due to movement disorders of a neurological origin from the actions and movements performed daily by the patient. The PD-Watch has already been tested during a preliminary clinical trial and is protected from an intellectual property standpoint.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'AIRCRAFT and ROTORCRAFT PILOT COUPLINGS – TOOLS AND TECHNIQUES FOR ALLEVIATION and DETECTION' (ARISTOTEL) under Seventh Framework.

assistant: **Objectives**

The ARISTOTEL project challenge is ensuring aircraft safety and aims to reduce the aircraft and rotorcraft accidents caused by a particularly unfavourable category of phenomena: aircraft-pilot-couplings and rotorcraft-pilot-couplings (A/RPCs). Generally, A/RPCs are defined as “inadvertent, sustained aircraft oscillations which are a consequence of an abnormal joint enterprise between the aircraft and the pilot”. Recent experiences show that modern designs are being confronted in an increasing degree with dangerous A/RPCs. The reason for this is that modern aircraft feature a significant level of automation in their flight-control-systems (FCS). FCS is generally intended to relieve pilot workload and allow operations in degraded weather and visibility conditions. Especially in the modern rotorcraft, there seem to be embedded tendencies predisposing the FCS system towards dangerous RPCs. As the level of automation is likely to increase in future designs, extending to smaller aircraft and to different kinds of operation, the consequences of the pilot ‘fighting’ the FCS system and inducing A/RPCs needs to be eradicated. It is the goal of this project to develop the design tools and techniques needed to detect and alleviate the A/RPC problems. End products of the project will be: 1) Advanced vehicle-pilot-FCS simulation models for “rigid body” and aeroservoelastic A/RPC analysis; 2) A/RPC design guidelines and criteria; 3) protocols and guidelines for A/RPC flight simulator training. All results will be directly useable by the aerospace industry in the design process for improving flight safety. The project will contribute in this sense to: 1) the minimization of the factors that lead to pilot loss of control resulting in increased enhancement of the European aircraft safety