RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Free/Libre and Open Source Software: International Cooperation development roadmap' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

FLOSS (Free/Libre/Open Source Software) is arguably one of the best examples of open, collaborative, internationally distributed production and development. FLOSS provides numerous benefits for developing countries, such as low cost, adaptability, and a free-of-charge high quality training environment, as shown by the FP6 FLOSSWORLD study.<br/>The FLOSSInclude project aims to strengthen Europe participation in international research in FLOSS and open standards, by studying what is needed to increase the deployment, development and societal impact of FLOSS in Africa, Asia and Latin America. The project will result in a sound understanding of the FLOSS-related needs of the target regions.<br/>It will federate local and regional development initiatives with the support of cooperation with current EU research. It will also provide a roadmap for future EU research cooperation in this area.<br/>To achieve these objectives, the FLOSSInclude project will perform five core tasks:<br/>1. analysis of available data to identify key problem areas and areas of blocked potential for FLOSS in the target regions<br/>2. dissemination and networking, to identify and federate local and regional initiatives<br/>3. requirements analysis, to show with concrete cases the specific technical, business and socio-political needs for the growth of FLOSS use, deployment and development in target regions<br/>4. validation and pilots, to ensure that FLOSS solutions, tools and services can be cost-effective and practical<br/>5. prepare a cooperation roadmap, supported by regional initiatives, concrete cases for clearly identified requirements, with solution areas proposed that have been validated through pilots.<br/>Validated pilots and a coordinated roadmap for future EU development research cooperati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Gas-Phase Sono-Photonics' (GASONIC).

assistant: **Innovation**

Over the past decades, modern photonics has evolved from a niche activity to a field of utmost scientific and economic importance. Strikingly, photonic devices ranging from lenses and fibres to complex machines such as lasers and microscopes rely almost exclusively on tailored interactions of light with solid matter. This fundamental principle imposes constraints, limiting e.g. the wavelength range of photonic devices due to absorption and the optical power due to damage.In a ground-breaking effort, we recently opened up an entirely new route to transfer photonic methods from solids to the gas phase: using intense ultrasound (sono) waves, gases can be tailored to enable light control. Building on this pioneering work, I will consolidate a new research field: Gas-Phase Sono-Photonics. Within GASONIC, I will develop solid-state free light guiding concepts ranging from simple light deflection in density-modulated gases to all-gas-phase damage-immune sono-photonic waveguides shaped by intense acoustic waves. Gas-phase light deflectors will enable innovative ultrafast optical switches to modulate, sample and stack laser pulses approaching the terawatt regime. Sono-photonic fibres will enable a whole new field for guided optical wave control, complementing established wave-guiding concepts. Moreover, by providing a direct link between advanced optics and electronics mediated by gas phase acoustics, sono-photonic methods will open up new degrees of freedom for light control including adaptive control schemes leveraged by intelligent optimisation routines.The proposed efforts will thus extend photonic methods into entirely new regimes, opening the door to adaptive light control at unprecedented power levels and in unexplored spectral regions. GASONIC thereby addresses key limit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Characterization of porcine complement regulatory molecules. Application toxenotransplantation' (1994-1998).

assistant: **Concept**

Research objectives and content Little is known about the regulation of complement in pigs and the current enthusiasm for using the pig as an organ donor for humans increases the need for an understanding of pig complement. Pigs are currently being engineered to express human complement regulators in the expectation that organs from these pigs will be less susceptible to damage by human complement and will escape hyperacute rejection. However, these experiments have been conducted in relative ignorance of pig complement and of its own regulatory molecules. This project is intended to accomplish a deep characterization of the pig complement regulatory molecules, mainly in the context of the pig to human xenotransplantation. Thus, it is focused in the three cell membrane-bound molecules: MCP (or CD46), CD59 and DAF {or CD55). We will characterise fully the tissue expression of these three molecule and to analyse their roles in vivo. We will address the species selectivity of pig complement regulators. This is, if porcine regulators inhibits the activation of the human complement and the relative efficiency of both systems. These latter questions have obvious relevance to pig-human transplantation. Finally, is intended to carry out several functional analysis of the regulatory capacity of these three molecules. We will assess the relative importance of the proteins in defence against homologous and heterologous complement. Training content (objective, benefit and expected impact) This project will provide new data which will be of value to those engaged in the design of animal organs for transplantation into humans. It will also provide novel information on the regulatory molecules of porcine complement and the possible role of complement regulators in homeostasis, fertili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Institutions for Resilient Groundwater Dependent Rural Economies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Groundwater is a strategic resource for modern economies worldwide; yet it is over-exploited at an alarming rate. New forms of governance are sought, in particular in rural areas with intensive agricultural irrigation where authorities lack the means to regulate large numbers of dispersed users. During the Fellowship, I will develop new understanding of strategies and institutional arrangements for increasing the resilience of groundwater dependent rural economies, and develop and test a methodology that support local actors to design collective solutions. Overall, the Fellowship aims to: (1) carry out a global assessment of strategies and institutions currently used worldwide; (2) develop a participatory foresight methodology to support the design of innovative strategies and institutional arrangements in two case studies; and (3) promote academic exchange and disseminate research. The Fellowship will enable me to strengthen my empirical and theoretical knowledge of the design of institutions for common-pool resource management and natural resource management, and position me as a leading scholar in the competitive research community on environmental and institutional economics. A carefully crafted series of scientific exchanges and collaborations will expand my outreach to a global level, and open opportunities for new research collaborations. The French Geological Survey (BRGM), France, is the ideal host organisation to carry out this research because of its established expertise on groundwater management with an emphasis on inter-disciplinary research of high societal relevance, and its extensive global networks. I will contribute to BRGM’s current research agenda and strengthen its collaborations in and outside Europe. My research will contribute to Europe’s knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Higher-Order Hodge Laplacians for Processing of multi-way Signals'.

assistant: **Concept**

Network analysis has revolutionized our understanding of complex systems, and graph-based methods have emerged as powerful tools to process signals on non-Euclidean domains via graph signal processing and graph neural networks. The graph Laplacian and related matrices are pivotal to such analyses: i) the Laplacian serves as algebraic descriptor of the relationships between nodes; moreover, it is key for the analysis of network structure, for local operations such as averaging over connected nodes, and for network dynamics like diffusion and consensus; ii) Laplacian eigenvectors are natural basis-functions for data on graphs and endowed with meaningful variability notions for graph signals, akin to Fourier analysis in Euclidean domains. However, graphs are ill-equipped to encode multi-way and higher-order relations that are becoming increasingly important to comprehend complex datasets and systems in many applications, e.g., to understand group-dynamics in social systems, multi-gene interactions in genetic data, or multi-way drug interactions.The goal of this project is to develop methods that can utilize such higher-order relations, going from mathematical models to efficient algorithms and software. Specifically, we will focus on ideas from algebraic topology and discrete calculus, according to which the graph Laplacian can be seen as part of a hierarchy of Hodge-Laplacians that emerge from treating graphs as instances of more general cell complexes that systematically encode couplings between node-tuples of any size. Our ambition is to i) provide more informative ways to represent and analyze the structure of complex systems, paying special attention to computational efficiency; ii) translate the success of graph-based signal processing to data on general topological
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Low-dose Computed Tomography for pediatric applications'.

assistant: **Concept**

X-ray computed tomography (CT) is a widespread medical imaging modality with 85 million examinations performed in 2012 in the US alone, but there is a need for improving instrumentation to minimize the potential health risks due to radiation dose. Although the benefits of CT imaging greatly outweigh the risks, the dose must be minimized, especially for children. Using other modalities may not be an option since ultrasonography lacks sufficient diagnostic quality and MRI is time-consuming, expensive and may require sedation of small children.At KTH Royal Institute of Technology, a photon-counting silicon-strip detector that promises better image quality and lower dose than today’s CT detectors has been developed. In the proposed project, this detector will be used to develop a new CT technique for imaging children: low-dose photon counting CT. To this end, a reconstruction algorithm for low-dose imaging will be developed and tested by imaging phantoms. The imaging performance will be compared to current state-of-the art CT and x-ray radiography systems.General Electric (GE) is a market-leading CT vendor with the experience necessary to turn this idea into a product used in the clinic. The applicant will therefore carry out the 12-month outgoing phase at GE Global Research Center, Niskayuna, in close collaboration with GE Healthcare, Milwaukee. During the return phase, the applicant will use the experience gained from GE Global Research for continuing the research into photon-counting CT at KTH. In this way, KTH gains access to the expertise of GE on image reconstruction while GE gets an opportunity to evaluate the feasibility of integrating the photon-counting CT detector into a commercial CT scanner.A successful outcome can have a large impact on children’s health by al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Probing Druggability of Multisubunit Complexes:  E3 Cullin RING Ligases' (DRUGE3CRLS) under Seventh Framework.

assistant: **Objectives**

This proposal is centred on the development and application of chemical tools to probe molecular recognition of multiprotein complexes. Although much effort has been devoted to targeting protein-protein interactions using small molecules, these have focused to date on individual gene products or truncated domains, which however do not reflect the physiological organization and activity of many functional proteins. Few successes have been achieved, yet many of the key physical determinants of druggability of surfaces within native protein complexes have remained elusive. The aim of this project is to shed light upon this problem by chemically interrogating biological systems that rely on several subunits working in concert rather than on single proteins working alone. As model system we will investigate the Cullin RING Ligases (CRLs), the largest superfamily of multisubunit E3 ligases in humans. These enzymatic machines are responsible for the recognition, poly-ubiquitination and targeting of substrate proteins to the proteasome for degradation. Many members of this family have crucial roles in cellular physiology and homeostatis, are implicated in a wide range of diseases and are attractive targets for drug discovery. Two interdependent lines of enquiry will be followed. First, we will screen for and elucidate the binding of small molecular fragments and short peptides to identify new druggable surfaces and interfaces on CRLs and their components. Second, we will exploit the nature of the interactions to develop novel chemical probes of CRLs. As the probes are selected and optimised for binding rather than for a particular functional outcome, diverse mechanisms of action are envisaged beyond conventional disruption of the interaction. The successes of this interdiscipli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Detection and analysis of the motion of molecular motors using a light scattering technique'.

assistant: **Objectives**

Research objectives and content We plan to elucidate the thermodynamics of energy transduction of an actin filament moving on a myosin sheet using a light scattering technique. A small-angle scattering geometry, together with a reference phase provided by a phase grating, should allow, according to preliminary calculations, to detect displacements in the 10 nm range. Direct informations on the actin dynamics will be provided by the autocorrelation function of the scattered light. This new non-perturbing technique should lead to data of major interest in the modelling of energy transduction of molecular motors and to study the transition from single to collective behaviours of actin as the density of actin heads is increased. Training content (objective, benefit and expected impact) The Institut Curie provides an excellent and well equipped environment with expertises in physics and biology. The expertise in light scattering and noise measurements of the candidate, together with the sample preparation skills at Institut Curie should allow to get significant advance in understanding the thermodynamics of molecular motors. A useful exchange of techniques and skills in complementary fields is expected. Links with industry / industrial relevance (22) The host institution has several joint programs with industrial partners as Rhone-Poulenc, Elf-Aquitaine and Michelin on the reproduction of the function of molecular motors at mesoscopic scales.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Week of Innovative Regions in Europe 2015 (WIRE VI)' (WIRE2015) targeting Horizon 2020.

assistant: **Abstract**

A three-day conference, Week of Innovative Regions Europe VI (WIRE VI), is proposed to be held in Riga during the Latvia’s Presidency of the European Union in 2015. The WIRE VI will focus on enhancing research and innovation investment as well as policy efficiency in the context of the new programming period (2014-2020). The WIRE VI will concentrate on the new specific objective of Horizon 2020 on Spreading Excellence and Widening Participation and will pay attention to the newly proposed measures to help address the innovation divide through actions on Teaming, Twinning and ERA Chairs, bringing excellence and innovation to research institutions. The links and synergies of research and innovation policy with Cohesion Policy and the specific tool of clusters will be examined, especially regarding the modalities stemming from the new legislation of the European Structural and Investment Funds. The conference will contribute to research, innovation and regional policy development following the traditions of previous conferences of WIRE series.


**Keywords:** Conference, Innovation, Presidency, Latvia, Europe, Policy, Horizon 2020
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Safe and effective pesticidal micro-organisms through customised environmental persistence' under Fourth Framework.

assistant: **Concept**

Chemical pesticides are an important tool of modern agriculture. However, the chermicals are implicated in environmental, ecological.and human health problems so a need exists to find effective, less deleterious, alternative approaches. The use of bacteria, in particular Bacillus thuringiensis, is one such option, whose cost-effectiveness is comparable to that of chemicals, but it suffers from several problems. The current proposal aims at improving bacteria with pest control properties by understanding and developing key tools relating to the persistence of the micro-organism in the environment. The objectives of this programme are:  1. To develop a classification system that allows bacteria to be assessed for specific outdoor applications. 2. To construct a bacterial strain with enhanced desiccation tolerance. 3. To improve the use of self destruction systems to limit bacterial persistence by constructing a prolonged persistence bacterial strain with a functional self-destruct system triggered by low temperature or absence of proline/pantothenic acid secretion from the roots of plants. 4. To develop a mathemathical modelthat allows improvements in the assesments of the risks involved in releases of micro-organisms in the environment. This model will then be used to assess the impact of the self-destruct and improved desiccation tolerance on the overall risk.  To fulfil these specific goals the following work programme is proposed:  A. Development of a prolonged persistence self-destruct system triggered by a drop in temperature or repressed by plant root exudates, and incorporating novel toxins from the relE-family. The systems will be inserted in desiccation tolerant Pseudomonas putida strains and the final construct tested in the field. B. Development of Pseudomonas