RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'North-south EXchange for Underground Science' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The nature of invisible dark matter (DM), which constitutes ~26% of the mass-energy balance of the Universe, remains a major puzzle in physics. Despite extensive searches, DM constituents remain undetected, though experiments have significantly constrained the allowed parameter space. The NEXUS project aims to advance this research by enhancing detector performance, refining instrumentation, and expanding theoretical insights through a sustainable expert network. Partnering with world-class laboratories in Europe, the USA, Canada, Australia, and South Africa, NEXUS will tackle extraordinary experimental and theoretical challenges. This research relies on Underground Laboratories (ULs), where cosmic rays are suppressed by ~1000 meters of rock, minimizing the cosmogenic backgrounds. The proposed NEXUS initiative aims to establish a global network of ULs dedicated to ground-breaking advancements in the field. The collaborative approach undertaken in NEXUS is designed to provide a dynamic environment for advances in ultra-sensitive detectors and ultra-low radiation techniques, ready to lead innovation in both the global search for rare events and cutting-edge technological development ultimately benefiting society and industry. ULs’ support for research will provide: (i) effective radiation shielding; (ii) above-ground and underground support facilities, such as clean (radon-free) rooms, radio-purity assay equipment, and cryogenic equipment; (iii) material production and purification facilities; (iv) tools and methods to characterize underground facilities and related instrumentation; and (v) a unique environment for multidisciplinary research. In addition, efforts are being made to further increase instrument sensitivity to meet new challenges in rare-event research. NEXUS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Electrochemical LEctin and glycan biochips integrated with NAnostructures'.

assistant: **Concept**

Glycomics is currently one of the most progressively evolving scientific fields due to ever growing evidence glycans (sugars) are involved in many aspects of cell physiology and pathology. Glycans are information-rich molecules responsible for sophisticated storage and coding “commands” the cell has to perform to stay “fit” and to deal with uninvited pathogens. Thus, it is very important the “glycocode” is correctly deciphered by the cell to stay healthy, but pathogens developed nasty tricks how to crack the “glycocode“ to their benefit by stealing glycan identity of the host to stay unrecognised until it is too late. A better understanding of these processes can help to develop new, potent and nature-based vaccines and drugs.Glycomics stayed behind advances in genomics and proteomics, but due to advent of high-throughput biochips glycomics is catching up very quickly. Two biochip formats available to study challenging and complex field of glycomics are either based on immobilised glycans (glycan biochips) or glycan recognising molecules – lectins (lectin biochips). Both technologies proved to be a success story to reveal amazing, precisely tuned “glycocode” reading, but so far biochips do not work under conditions resembling natural process of glycan deciphering.The aim of the project is to develop biochips for fundamental study of the effect of precisely tuned ligand (glycan and lectin) density, presence of mixed glycans and the length of glycans on the glycan biorecognition. This task will be executed with the aid of nanotechnology to control these aspects at the nanoscale. Moreover, novel label-free electrochemical detection strategies will be used to mimic natural glycan recognition performing without any label. Finally, advanced patterning protocols and novel dete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Knowledge Transfer in Global Gender Programmes: The Case of Female Genital Mutilation/Cutting and Gender-Biased Sex Selection' under Horizon 2020.

assistant: **Concept**

Global challenges require global policy solutions. The Global Programme to Prevent Son Preference and Gender-biased Sex Selection (2017-2019) and the Joint Programme on the Abandonment of Female Genital Mutilation/Cutting (2018-2021), both co-funded by the European Union (EU) and carried out by the United Nations (UN), are representative of a range of new initiatives that seek to share knowledge and enact policy change across different jurisdictions. Despite the promise of such global programmes, however, the challenges involved in working across different cultures and policy regimes may prevent them from fully achieving their goals. Very little is known about how knowledge is transferred through these programmes and how it translates into concrete policy. GlobalKnoT assesses knowledge transfer in the Global Programmes on Female Genital Mutilation/Cutting (FGM/C) and Gender-biased Sex Selection (GBSS) to inform academics, practitioners and the public about their functioning and efficacy in providing solutions to global public challenges. By applying the Actor-Network Theory to global policy studies and drawing from policy files, participant observation during international conferences, and expert interviews with UN, WHO and EU officials and policy makers, this project provides a detailed map of the actors and networks involved in global policy. It informs us how knowledge diffusion can be optimized to accelerate change towards eliminating two pervasive forms of gender discrimination and advance the 2030 Agenda for Sustainable Development.


**Keywords:** Global social policy, global programmes, comparative policy analysis, knowledge transfer, policy transfer, SDG 5, harmful practices, gender-biased sex selection, female genital mutilation, cutting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Atlantic Late Bronze Age Interaction through Metal Hoards' (ALBIMEH), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to examine the nature and the degree of interaction between the Late Bronze Age communities of the European Atlantic façade (c. 1300-850 BC) through the study of metal hoards. We propose to determine the similarities and differences expressed by the hoards in different spheres (economic, technological, ideological and religious) by undertaking an intensive and comparative study of the phenomenon in four selected geographical areas. To achieve this objective, priority will be given to obtaining data using a standardised methodology in areas located in different regions on the Atlantic façade (Portugal, Spain, France and England). This is a crucial aspect as previous studies have often been based on partial information that is not very standardised and therefore difficult to analyse in an integrated manner.Hoards constitute an excellent source of information for tracing technological and cultural similarities and differences over extensive geographical areas, given that they reflect deliberate acts of hiding, offering or depositing certain objects. While other facets of the archaeological record may be the result of chance or routine action, in the hoards there is an intentional and conscious dimension that is in keeping with specific, culturally important ideological schemes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targeting downstream effectors of Wnt signaling in colorectal cancer' (ColonCan).

assistant: **Concept**

Colorectal cancer (CRC) is one of the most common cancers of the western world. The underlying initiating mutation for the majority of CRC is within the Adenomatous Polyposis Coli (Apc) gene. The APC protein performs an important role in controlling the levels of Wnt signalling by targeting beta-catenin for degradation. Loss of the APC protein leads to the activation of Wnt signaling target genes such as c-Myc which is required for phenotypes causes by Apc loss.However, despite the clear importance of APC loss and deregulated Wnt signalling, additional events are required for the development of CRC such as KRAS and P53 mutations.The impact of these changes on the development of CRC and response to therapy is not well understood. Furthermore, identification and testing of potential novel targets and therapies is hampered by lack of a preclinical model that faithfully recapitulates the course of the human disease.This proposal has two aims:1. Assess the impact of cooperating mutations with Apc and assess how they alter sensitivities ofApc deficient cells.2. Develop mouse models of invasive and metastatic colorectal cancer that recapitulate the human disease.We will use ‘state of the art’ methodologies to identify the changes in signaling output conferred by these cooperating mutations. Genetic mouse models of invasive and metastatic colorectal cancers will be generated through the acquisition of additional mutations and genomic instability.These studies will produce predictions on therapeutic combinations that will be tested in mouse models in vitro and in vivo that may identify new treatment regimens for patients with late stage CRC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LIGNin-IRON complexes for removal of nano-plastics in enhanced coagulation-flocculation from water', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Recent advances in lignin nanotechnology have opened up new possibilities not just for underutilized lignin side streams but also for hybrid organic-inorganic nanocomposites. One specific instance is mixing metal ions with lignin nanoparticles (LNPs) to create new materials with desired superparamagnetic properties. Currently, limited knowledge exists regarding the interaction between LNPs and iron, which is what LIGNIRON intends to fill. Additionally, there is no indication of how iron oxide nanoparticles can be encapsulated into LNPs in a reproducible and uniform manner. Identifying these gaps and unlocking the full potential of the lignin-iron complex requires developing fundamental knowledge of the lignin-iron surface chemistry using microfluidic systems where a variety of opportunities exist for studying hybrid material formation. The combination of this knowledge with electrospinning processes would result in a new method that may translate academic research into practical application for continuous mass production of lignin-iron hybrid materials. By achieving these objectives, LIGNIRION paves the way for the application of LNPs into innovative functional materials and creates a new high-volume, high-value end-use for lignin, thereby contributing to the implementation of the EU circular economy policy. Ultimately, the new materials are designed to be used as as retrievable flocculants to remove nano-plastic from water, enabling EU water treatment plants to be effectively prepared for future combat against nano-plastics without significant infrastructure expansion costs.


**Keywords:** Lignin,  circular economy,  nano-plastic removal,  inorganic -organic hybrid material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Surrealism as Multicultural Experience: The Transatlantic Bonds of the Surrealist Group and the Self-Reevaluation of Latin-American and European Cultural Identities' under Horizon Europe.

assistant: **Concept**

By studying a set of surrealist cultural journals edited during the 1930s and 1940s, MULTISURREALISM will examine the intercultural exchange between surrealist Latin American and European artists and writers, to analyze the way their ideas, agreements, tensions, and debates had an impact on the revalorization of the Latin American artistic and symbolic production, as well as on the understanding of European civilization. With an interdisciplinary approach (Literature Studies, Visual Arts Studies, Graphic Design, Discourse Studies, History of Ideas), the research will focus on the literary and artistic production of the surrealist multicultural network, as it has been manifested in magazines such as Minotaure (Paris, 1933-1939); VVV (New York, 1942-1944); Dyn (Coyoacn, 1942-1944); El Uso de la Palabra (Lima, 1939); Las Moradas (Lima, 1947-1949); Mandrgora (Santiago, 1938-1942) and Leitmotiv (Santiago, 1942). The overall hypothesis states that the surrealist multicultural relation promoted a different glance over Latin American culture since the assumption that Latin America is a land where surrealism arises naturally belongs to an ethnocentric perspective constructed by both European and Latin American surrealists. Still, it simultaneously allowed them to question the assumed subordination of Latin American culture, giving a new shape to its identity and influencing its Literature until the rise of the Latin American Boom. The project aims to connect different archive materials to analyze what this movement wanted to express, and also its unintentional effects and underlying meanings, to study its impact as a multicultural group. The final goal is to broaden the perspective about surrealism's role in the Latin-American culture of the XX Century, which promoted transatlan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An innovative people localisation system for safe evacuation of large passenger ships' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Maritime disasters in recent years are a stark reminder of the imperative need for timely and effective evacuation of large passenger ships during emergency. The Lynceus2Market project addresses this challenge through delivering a revolutionary operational system for safe evacuation based on innovative people localisation technologies.The system consists of: 1) Localisable life jackets that can provide passenger location in real-time during emergency 2) Smart smoke detectors that also act as base stations of an on-board localisation system 3) Innovative localisable bracelets able to send activity data to the emergency management team 4) Low cost fire and flooding escalation monitoring sensor notes 5) novel mustering handheld devices for automatic identification and counting of passengers during evacuation 6) Smart localisable cabin key cards 7) Intelligent decision support software able to fuse all localisation, activity and disaster escalation data to provide an integrated real-time visualisation, passenger counting and evacuation decision support 8) Innovative shore or ship-launched Unmanned Aerial Vehicle for localising people in the sea in short time and assisting search and rescue operations when accident occurs in extreme weather, during the night or in a remote location 9) Low-cost rescue-boat mounted radars for people localisation in the vicinity of the boat.The proposed project is based on the promising results developed in the FP7 LYNCEUS project where the innovative technologies were tested in lab and in small scale pilots. Lynceus2Market brings together European global players in the field, such as cruise ship owners, operators, ship builders, maritime equipment manufacturers, a classification society, industry associations and important technology organisat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Visualising Chromatin Structure and Dynamics at the Nanometre Scale with Super-Resolution Fluorescence Microscopy' (VCSD) under Horizon 2020.

assistant: **Objectives**

Recently, it has become evident that the spatial organization of chromatin within nuclei is a key factor that can regulate gene silencing and expression. This organization is particularly important in pluripotent stem cells that differentiate into all cell types of the body through chromatin remodelling coupled to altered gene expression. Therapeutic use of these cells demands precise control over chromatin structure to direct differentiation. However, chromatin structure remains poorly resolved due to the nanometre length scales involved and limitations of low spatial resolution, poor signal-to-noise and ensemble averaging in existing methods. VCSD utilizes cutting-edge super-resolution fluorescence microscopy (SRFM) that overcomes these limitations. VCSD will, for the first time: 1) visualize global, 3D chromatin nanoscale structure in individual cells during differentiation; and 2) correlate the dynamics of local chromatin restructuring with the silencing of a central pluripotency gene. The proposed Marie Curie Fellow, Jason Otterstrom, PhD Harvard Biophysics, has extensive experience in fluorescence microscopy applied to biological systems. The host lab supervisor, Dr. Loza-Alvarez, is an expert in SRFM, at the Institute for Photonic Sciences, Barcelona. A secondment is planned in the lab of Dr. Cosma, an expert in the genetic mechanisms controlling pluripotency, at the Barcelona Center for Genomic Regulation. The combined expertise of the fellow and host labs is uniquely suited to establish VCSD as a novel framework for characterizing chromatin structure. The methodology developed is anticipated to be adopted by researchers in stem cell and chromatin biology fields, thereby reinforcing Europe’s global reputation in scientific innovation. The Fellowship will enable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Characterizing Surface-Supported Microdroplets for Optofluidics Applications' (MICRODROPLETS) under Seventh Framework.

assistant: **Objectives**

Liquid microdroplets have a spherical geometry, smooth surface, and their size and shape can be easily tuned. These properties make them ideally suited for many optical applications. However, microdroplets have up to date found only a limited use, mainly due to the difficulty in their position stabilization. Traditional position stabilization techniques such as electrodynamic levitation, optical levitation, and optical tweezing suffer from fragility and do not allow integration with other optoelectronic components. Superhydrophobic supporting surfaces provide a natural solution to this critical problem. In addition to preserving the spherical geometry of microdroplets of water and other hydrophilic liquids, they provide a highly robust position stabilization mechanism and allow interfacing with other necessary components of integrated lab-on-a-chip systems. The main scientific objective of the proposed research project is the exploration of the intriguing optical properties of surface-supported liquid microdroplets that can act as ultrahigh-quality tunable optical microcavities. Using tapered fiber coupling of a tunable-wavelength laser light into the droplets, we will explore their ultrahigh-quality optical modes for various combinations of droplet size, shape, and refractive index. We will build upon the existing expertise that has already been obtained in the host laboratory and extend the fundamental knowledge that is crucial for applications of supported microdroplets in integrated optofluidic systems. Subsequently, we will also investigate the potential of microdroplet-based resonant cavities for molecular sensing applications. We expect that our results will pave way for practical utilization of microdroplets as highly-flexible micro-optical components of integra