RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Building a computational basis for the brain response in the left ventral occipito-temporal cortex: Understanding the Sparse Familiarity Model of visual word recognition', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The left ventral occipito-temporal cortex (lvOT) is an integral part of the ventral visual processing stream and is consistently activated in response to visual words. Recently, I developed a computational implementation of the lvOT functioning during visual word recognition, the sparse familiarity model (SFM). The single assumption of the SFM is that the statistical patterns of letter string familiarity are the fundament of lvOT functioning. The SFM is able to simulate prominent lvOT benchmark contrasts and its simulations predict brain activation of the lvOT in multiple fMRI studies. The main aim of the present proposal is to use the model to systematically investigate hotly debated topics in word recognition research concerning current theoretical approaches for the lvOT: (1) The influence of learning and (2) domain specificity (i.e. for words) vs. generalization (i.e., to face and object recognition) of lvOT function and neuronal populations. In the course of these investigations, the SFM will be developed into a learning model and a generalized model for word, face, and object recognition. Central to this will be high-density electrophysiological measurements (MEG) that sample brain activation with high temporal resolution and reasonable spatial resolution, to allow connectivity analysis at different time points. The MEG measurement, in addition to fMRI measures, will be essential to test theoretical assumptions concerning the proposed two stages of the SFM that differ fundamentally in terms of neuronal and cognitive mechanisms. Critical will be the association of these stages to different time windows and assumptions about the brain networks involved. The host, Prof. Fiebach at Frankfurt University, has a strong focus on the neurocognitive basis of language and ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Migration and New European Identities between Social Integration and Social Exclusion' in the context of a Fifth Framework call.

assistant: **Objectives**

In the present phase, in all European countries and areas interested by migratory processes (of both old and new migration), phenomenons of increasing changes both in social and cultural life and in labour markets structures are registred.Consequently, there is an urgent need of a critical, substantial revision of interpretative patterns and approaches produced in the past (even recent), in migratory studies. In other words, the entire scientific production in this field in the last fifty years should become object of research itself, starting from its own multidisciplinarity in the training of young researchers. The in-depth study of basic processes of social transformation is a basis both to research-action and technological research.The European political context has also changed, affecting migratory policies. The new geographic and symbolic European Union identity - as it seems to emerge by the Maastricht Treaty and the Schengen Accord texts- has moved its own frontieers towards peripheral countries, which find themselves obliged to manage border, reception and integration politics in front of the pressure of migratory flows (this need will grow, as integration augments amongst State members of the Union). These countries migratory experience (as receiving countries) is recent and has developed in a contradictory manner, both in migratory policies and social practices in front of immigrants.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00161-2.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Grenoble Outstation of the European Molecular Biology Laboratory' in the context of a Fourth Framework call.

assistant: **Objectives**

Principal eharacteristics of the facility and of the support offered to users: The European Molecular Biology Laboratory (EMBL) Grenoble Outstation collaborates intimately with the European Synchrotron Radiation Facility (ESRF), the world's first third generation synchrotron source, in providing state-of-the-art synchrotron radiation facilities to European structural biologists in a strong structural biology research environment. The exceptional intensity and high collimation of the ESRF beams permits diffraction experiments to be made on weakly diffracting biological samples, notably micro-crystals and very large complexes (e.g. viruses), or time-resolved studies, that cannot be performed elsewhere. The beamlines at the ESRF available for structural biology, particularly protein crystallography, are a high brilliance undulator beamline for macromolecular crystallography (ID2), a bending magnet beamline optimised for MAD crystallographic experiments (BM14), a microfocus beamline designed for the study of micro-crystals (ID13), an undulator beamline equipped for time-resolved crystallography (ID9) and a multi-endstation macromolecular crystallography beamline (ID14, due for commissioning in late 1997). Visitor access for measurements on these beamlines is offered as well as facilities for longer term stays for training purposes and for scientists wishing to tackle particularly challenging experiments in structural biology requiring extended interactions with EMBL biologists and beamline scientists. Quantity of access being offered and number of users who may benefit: Beam time Access offered: 280 days over three years Number of users: 110 user groups (330 people) over three years
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigating the Ecology, Composition and Exploitability of Wild Cereal Habitats in Relation to Agricultural Origins in the Near East' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The project combines analyses on the taxonomic composition, isotopic signature, economic exploitability and functional ecology of wild cereal habitats in the Near East, which will create a data basis that allows to more reliably trace the origins of arable weeds and the development of subsistence strategies at the dawn of agricultural societies. During the past decades, archaeobotanical research on early cultivation has strongly focused on the wild cereals, their experimental cultivation, and on identifying arable weeds in archaeobotanical assemblages for tracing the first cultivation activities. However, little is known about the origins of arable weeds and their association with unmanaged wild cereal habitats, putting doubt on their reliability to indicate the beginnings of cultivation. In addition, medium- and large-seeded wild grasses that grow together with wild cereals in modern stands occur abundantly at Early Neolithic sites. Reconstructing subsistence developments during the Neolithic transition must therefore consider the exploited “non-cereal” grasses more thoroughly. The project aims to address these research gaps by (1) investigating the association of potential arable weeds with unmanaged wild cereal habitats, (2) analyse the stable carbon and nitrogen isotope ratios of the different grass taxa in order to test whether these signatures significantly differ between habitats and (3) test the harvesting efficiency of medium- to large-seeded wild grasses in relation to the wild cereals. The harvesting experiments will also show whether unwanted “weed seeds” become incorporated into harvests from unmanaged stands, falsely indicating cultivation activities. Finally, we will combine these investigations with an analysis of the functional traits of the recorded sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nanoarrays: Self-assembled Hotspots for Enhanced Analyte Detection' (N-SHEAD).

assistant: **Concept**

I aim to transform the way disease is currently detected through innovations in the design of nanoparticle-based biosensors that can be used to detect a number of diseases with global implications. The three most significant challenges facing biosensing are inaccuracy, insensitivity, and low-throughput detection. One technique that is capable of facing these challenges is Surface Enhanced Raman Scattering (SERS) which has demonstrated potential for extreme sensitivity (single molecule detection) and rapid, multiple-analyte detection within complex mixtures. Early stage diagnosis of disease requires the detection of trace amounts of analyte in multi-component biological samples (blood, urine, saliva). It is therefore particularly important for sensors to reach the single-molecule detection limit. Further, the ability to analyse biological samples without separation or other treatment steps is a crucial advantage of SERS.My approach involves the electrotuneable self-assembly of plasmonic nanoparticles at a liquid-liquid interface for SERS detection, overcoming the severe limitations of current sensors (sensitivity, specificity and speed). I will electrochemically control the positioning of the nanoparticles in a precise manner to maximise the Raman signal. Additionally I will utilise shaped nanoparticles, such as stars and ellipsoids, exploiting the enormous Raman enhancements observed at sharp metallic tips to push the sensitivity towards single-molecule detection limits. The ultrasensitive sensing capabilities will be extended to colorectal cancer diagnosis the third most prevalent cancer in the world which effects 1.4 million people per year.   Due to the versatility of this system it can be adapted to any disease or virus where the related biomarker is known. This app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PNEUMOSIP', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

PneumoSIP project aims to be the first fully automated device in the POC market for the fast quantitative aetiological diagnose of Community-Acquired Pneumonia (CAP) also analysing antibiotic resistances to enable the most appropriate treatment for each infected patient.CAP is known to affect about 1/1,000 of the adult population per year, being even higher in the elderly and children populations. It is the fourth case of death in the world, and the leading cause of death in child population under 5 years old. The causal relationship between pathogens and pneumonia has been clearly established, being Streptococcus pneumoniae, Haemophilus influenzae type b (Hib) and the respiratory syncytial virus (RSV) the main pathogens responsible for CAP in Europe. Antibiotic therapy is the mainstream treatment for CAP, and the appropriate treatment involves starting empiric antibiotics administration within 8 hours of hospital arrival. Given this time constrain, traditional methods for diagnosing the aetiology of CAP have been discarded for CAP guidelines due to the slowness in sample to results. Another complication is that S. pneumoniae is a common colonizer of the nasopharynx (up to 70% of healthy population acts as a host), making the simple detection of the bacteria a useless diagnostic method. Thus, clinicians need rapid and accurate quantitative tests capable of identifying infectious agents and their potential antibiotic resistances. Therefore, PneumoSIP project aims to be a compact Respiratory Infectious Diseases diagnostic device providing fast quantitative identification of pathogens involved in CAP, enabling faster and more specific treatments. PneumoSIP seeks to combine laboratory standard precision with the simplicity required for POC applications. The market for Pneum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'POWERING ARTISTIC AND CULTURAL ENTREPRENEURSHIP TO DRIVE THE CLIMATE TRANSITION' (PACESETTERS), addressing dissemination and exploitation.

assistant: **Impact**

PACESETTERS responds to the abstract challenge of the climate transitions by shifting from a model of entrepreneurship based on individual, short-term incentives to one that is driven by co-agency and new capacities to act together in sustainable ways. It does so by examining the concrete circumstances, investigating possible support mechanisms and stress-testing instruments that enable art and culture, creativity and heritage to drive the climate transition.Therefore, PACESETTERS will set out to:-Create knowledge from collaborative research to keep pace with the transition-Propose and test creative business models to set the pace of the transition-Assess strategies of valorisation to push the pace of the transition This approach will identify and analyse advanced practices that run transversally across the cultural and creative sectors; contextualise the outcomes of co-research in real-world laboratories for social imagination; further develop and promote the preliminary results of experiments in iterative support and evaluation frames. The PACESETTERS approach centres on inclusion, participation and iteration in order ensure that gender equity and diversity inform it at every step and on every level.The result will be a critical evaluation and all-encompassing demonstration of the actual potentials of the CCIs to drive the climate transition while systematically analysing their impact on micro-, meso- and macro-level:-Understanding the climate transition as a triple transition: green, digital and inclusive-Innovating aPACESETTERS responds to the abstract challenge of the climate transitions by shifting from a model of entrepreneurship based on individual, short-term incentives to one that is driven by co-agency and new capacities to act together. It does so by examini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The plasticity of the self: experimenting with self-identity in the face of change' to be submitted under Seventh Framework.

assistant: **Abstract**

We normally entertain a fairly continuous and stable sense of personal identity, as we acknowledge that we are the same person, independently of what happens to us. The question of how our sense of self is maintained or changed across time is a key topic in psychology. Our self must possess sufficient plasticity, that is, adaptive processes of re-organization, to ensure assimilation of changes and a sense of continuity over time. To study the plasticity of the self, we will investigate how the experience of a changing body updates or alters our sense of self, in two parallel projects.First, we will study what is currently considered to be the most radical change in one’s body, the case of face-transplantation. In face-transplantation, the acquisition of a new face is a medical fact, while the experience of a new identity is an unexplored psychological outcome. We will investigate the plasticity and continuity of the self caused by face-transplantation by testing self-identification in individuals before and after the operation, using experimental psychology and functional neuroimgaing methods. Second, we ask how our own body-image affects the way we perceive other people. We will address this second question by investigating how changes in body-representation, caused by experimental manipulations of bodily illusions, can consequently affect social cognition processes, using experimental and social psychology methods.The question of the plasticity of the self is timely, because the modern self, due to societal, technological and medical advances, seems to be exposed to new, often radical, possibilities of change. The proposed project aims at understanding the basic mechanisms behind the plasticity of the self, by integrating research methods from experimental and social
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Autoantibodies and chronic pain -  Unraveling new mechanisms contributing to pain in rheumatic disease' (ANTIBODYPAIN).

assistant: **Innovation**

Pain is one of the most problematic symptoms of rheumatic disease such as rheumatoid arthritis (RA) and fibromyalgia (FM). We have earlier discovered that antibodies (immunoglobulin, IgG) purified from blood of seropositive rheumatoid arthritis (RA) patients induce pain-like behavior when transferred to mice, independent of inflammatory reactions. Even though FM is not considered an autoimmune disease, it has been suggested that neuroimmune dysregulation contribute to the pathogenesis. Therefore, we purified IgG from FM patients and found that also IgG from FM patients, but not healthy controls, have pronociceptive properties in mice, and surprisingly, bind to satellite glial cells in dorsal root ganglia. Our findings highlights the importance of expanding our view on which chronic pain conditions that could have an underlying autoimmunity as part of the pain pathology. Thus, the overall objective of this project is to investigate both general, and disease specific, pain-inducing mechanisms mediated by RA and FM IgG. Objective 1.  Investigate how IgG from RA and FM patients induce pain-like behavior after transfer to mice Objective 2.  Search for RA and FM IgG induced maladaptive changes in sensory neurons that mediate hyperexcitability and long-term pain-like behavior Using patient and healthy control samples, in vivo mouse behavioral assays, primary neuronal and non-neuronal cell cultures together with stat-of-the-art methodology, we will investigate how RA and FM-associated autoantibodies alter sensory neuronal excitability. If successful our project will not only challenge the view of how antibodies can contribute to pain but also pin-point specific mechanisms by which disease-relevant antibodies induce and maintain pain independent of previously described inflammat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Gene therapy of vascular endothelium to combat diseases of, or controlled by, the vascular system' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objectives of the proposed study include: 1- To develop adenoviral and other vectors to direct endothelial cell specific, long term expression 2- To test strategies to prevent vascular cell activation in inflammation and atherosclerosis 3- To create an endothelial cell layer which interferes with the action of T cells in allotransplants 4- To design novel strategies to block tumor angiogenesis 5- To direct synthesis of peptides to the brain in models of stroke and degenerative brain diseases Brief description: Vascular endothelium forms a biological interface between circulating blood elements and the subendothelial cells and controls the exchange of substances, peptides and immune cells between the blood stream and all the various tissues of the body. The single-cell thick endothelial cell membrane is a multifunctional organ which is essential to normal vascular physiology and homeostasis. Endothelial dysfunction can be triggered by infectious agents and an imbalanced activation of the immune system, which leads to inflammation, coagulation and changes in blood flow due to vessel obstruction. Overproliferation of vascular cells is associated with restenosis and atherosclerosis and the induction of capillary growth is a prerequesite for the growth of solid tumors. Due to its accessibility from the blood stream and its intimate relationship to all tissues of the body the endothelium is a candidate organ to test, by the use of genetic methods, strategies i) to prevent a series of vascular dysfunctions and ii) to direct production of peptides to certain organs such as the brain. This project proposes to generate novel viral vectors to direct transgene expression to the endothelium and to achieve long term transgene expression. We have available from our previous work r