RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Neandertal spine and thorax anatomy: 3D reconstruction, ontogeny and phylogeny' (NeanderSTAN) under Seventh Framework.

assistant: **Objectives**

The vertebral column and thorax are key anatomical regions in human evolution to understand upright bipedal posture and locomotion in terms of weight transmission, equilibrium, habitual loading and kinematics. Additionally, the vertebral column protects the spinal cord, and the size of the spine canal can offer a glimpse into the neurological basis on which throwing abilities and speech evolved, among others. Finally the study of the size of the thorax due to its relation to lung size and thus to ventilatory capacities can be helpful to assess the bioenergetics of an extinct human species.The most abundant fossil record of vertebrae and ribs of an extinct hominin is that of Neandertals (Homo neanderthalensis). Evidence points towards differences between the vertebrae and ribs of Neandertals compared to modern humans. They show larger thoraxes and a less sinuous lumbar region, among others. However, the exact shape of the Neandertal torso is still a matter of speculation. Additionally, the loading pattern and equilibrium of a larger chest and its relation to a less curved lumbar region remains obscure, not to mention its potential influence on bipedal gait.The aim of this project is to study the Neandertal vertebral column and thorax both metrically analyzing the individual vertebrae and ribs, and using modern 3D virtual reconstruction techniques on CT scanning of key Neandertal individuals. The latter will allow a better understanding of the morphology and biomechanics of these regions and significantly contribute to the understanding of Neandertal bioenergetics, a potential factor influencing their extinction. Additionally it will offer the comparative framework in which to analyze the evolution of the vertebral column and thorax of our own species.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dielectric spectroscopy and complementary techniques for molecular dynamic study of polymers and organic crystals' (DIELPOL), addressing dissemination and exploitation.

assistant: **Impact**

The proposed knowledge transfer aims to increase the competences of the researchers and PhD students at TUL in the field of broadband dielectric spectroscopy and their abilities to work with other complementary techniques, like dynamic mechanical analysis, computing techniques, low-frequency Raman spectroscopy, modulated DSC, which allow to study molecular relaxations and transitions in organic and polymer materials.This should result in more effective use of the equipment available at TUL and give theoretical and methodological backgrounds for more deep interpretation of the experimental results. The objectives will be implemented by two ways: recruitment of external experienced researchers and training of own staff in partner organisations. The training visits at partner organisations will give an access to the most advanced experimental techniques used for investigations of molecular dynamics in polymers and organic crystals.Characterisation of molecular dynamics in polymers is necessary for understanding the structure/properties relationships in modern materials such as semiconducting polymers for opto-electonic applications, nanogels, hyperbranched polymers, liquid crystals materials, which are currently investigated at TUL in a frame of European and national projects. Establishing of long-term co-operation with the scientific centres equipped with modern apparatus not accessible in Poland, and with the high experience staff will help in preparation and realisation of the common projects in the field of material engineering.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Quality of life in a changing Europe' (QUALITY).

assistant: **Innovation**

One of the most pressing challenges within the EU is to balance economic performance against socially sustainable forms of work organisation, quality jobs, and the preservation and improvement of the quality of life in the broadest sense. At the European Council meeting of 22/23 March 2005, the EU reiterated that growth and employment in an enlarged Europe, need to go hand in hand with the social quality of work and life. QUALITY is an innovative, quantitative and qualitative research project that aims to examine how, in an era of major change, European citizens living in different national welfare state regimes evaluate the quality of their lives.The project will analyse international-comparative data on the social well-being of citizens and collect new data on social quality in European workplaces in eight strategically selected countries: UK, Finland, Sweden, Germany, the Netherlands, Portugal, Hungary and Bulgaria.Overall aims of this project:a. to give insight, from an internationally-comparative perspective, in the quality of life and work of European citizens, the way the quality of life and work are interrelated, and the impact public and organisational policies have on the well-being of European citizens;b. to increase our knowledge how and under what conditions European workplaces could be transformed into healthy organisations, where work is organised in a socially as well as economically sustainable manner;c. to explore future trends by consulting national high-level groups (policy-makers, politicians, researchers, managers) and by constructing scenarios with respect to trends concerning the quality of life and work of European citizens;d. to analyse whether, to what extent and how gender matters in the relationship between well-being and public and organisa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'SPILL RESPONSE EXPERIENCE'.

assistant: **Innovation**

On 13 Nov. 2002 the Bahamian-flag tanker PRESTIGE ran into trouble during a storm 34 km off Cape Finisterre and began to leak its cargo of 77, 000 tonnes of oil. After drifting for six days along the coast, the tanker broke in half about 225 kilometres off shore, having spilled about 11, 000 tonnes of oil. Several hundred kilometres of coastline were coated in oil sludge by the disaster, especially Galicia but also Asturias, Cantabria and Basque country in Spain as well as several departments in western France.Objectives of SPILL RESPONSE EXPERIENCE COORDINATION ACTION-SPREEX CA are based on existing experience for response to oil spills. Objectives are as follows: identify research needs, propose clusters of existing projects included in different work programmes, generate synergies for building new projects and partnerships between authorities and regulators, end users, university and researchers.SPREEX CA will elaborate a plan of recommendations based on analysis of four themes:- Rolls of each party dealing with spills response.- Oil spill response vessels (OSRV) and the equipment.- Spill response Its.- Environmental impacts of spills and costs.For the analysis of each theme, a work group will be set up and three workshops will be held. A steering committee will also be set up and its members will follow the debate of the four groups and joint after each meeting of the groups. So that the steering committee will be in charge to elaborate a single document of recommendations which will be given to the relevant policy makers and other stakeholders, at national and international level. Finally, at least one conference will be hold and all partners will take part. A management team guarantees the success of the CA. This team will be integrated by persons with great exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative cancer management: First in human senescence imaging' (SenPET) under Horizon 2020.

assistant: **Objectives**

The irreversible growth arrest, termed cellular senescence, plays a key role in tumor progression and promotion, as well as in many other physiological processes. It has been shown to be a predictive marker for the long term outcome of cancer treatment and novel therapies aiming at the elimination of senescent cells are under development (i.e. senolytics). Therefore, techniques for the detection of senescence are of utmost importance. However, in the current clinical setting this is only possible with histological staining after collection of invasive biopsies and a tool for non-invasive assessment and quantification of senescence is highly desirable towards improved patient care and personalized medicine.Within our current ERC project ImageLink we have developed a stable and reproducible synthesis protocol for a novel radiolabeled PET-tracer targeting ß-galactosidase, the “gold-standard” biomarker of senescence. The tracer was validated in several in vitro and in vivo human and murine tumor models. A clear distinction between senescent and non-senescent tumors was possible and the convincing results have encouraged us to translate our preclinical findings into a clinical setting. However, this step exceeds the scope of our current ERC project.Within the planned project SenPET we will establish an automated radiosynthesis of the tracer that is compliant with good manufacturing practice (GMP) and all necessary paperwork with the authorities for approval of a clinical study will be accomplished. Finally we will perform the first clinical proof of concept study of a senescence PET tracer in 10 patients suffering from gastrointestinal tumors. PET data with our novel tracer will be collected before and after a senescence inducing chemotherapy treatment and correlated with ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New Approaches in the Crystallisation and Crystallography of Membrane Proteins' to be submitted under Fourth Framework.

assistant: **Abstract**

Membrane proteins perform a staggering range of blological functions. Structural research on membrane proteins is, however, only a partially conquered area; only 6 independent structures of integral membrane proteins have been reported so far. A more fundamental understanding of the structure-function relationships in membrane proteins requires the development of new techniques and methodologies, and would make invaluable contributions to structural biology, physiology and medicine. It is extremely difficult to purify and crystallise membrane proteins. Even if the proteln can be crystallised, there follows usually a set of other problems ln structure solution, mainly due to the often very low quality of these crystals. A breakthrough in the crystallography of membrane proteins requires new approaches in protein purification, crystallisation and data collection. Our main objectives are to develop these new techniques. We intend to undertake 3-dimensional structural studies on a wide range of integral membrane proteins and to perform dynamic structural studies on these systems to gain new insights into their mechanism. Inter-Europe collaboration with laboratories who have already achieved large scale preparation and crystallisation of membrane proteins plays an essential part in the project. We propose to start with respiratory membrane proteins, where we have already obtained high quality crystals. Development of new techniques will proceed in parallel with these studies. The new techniques will then be applied to new membrane protein systems.  TASK 1: Structural studies of respiratory membrane proteins. (1) High resolution and kinetic crystallography on respiratory oxidases (2) Structural analysis of cytochrome bcl complex (3) Structural studies on complex I and related
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ultrafast dynamics of chemical reactions in solution' (MPGMC) targeting Seventh Framework.

assistant: **Abstract**

The field of gas-phase reaction dynamics is well developed, facilitated by a vast array of sophisticated experimental and theoretical techniques.  Gas-phase studies have proved vital for developing our understanding of chemical reactivity, but most reactions in nature and practical chemical synthesis occur in the liquid phase.  Reaction dynamics in the liquid phase are far less understood, but recent improvements in ultrafast laser technology now make the kinds of time-dependent study required to probe such dynamics possible.   Interactions with solvent molecules may, for example, alter the relative energies of reactants and products, or affect the stability of intermediate structures, and dampen their motion through solvent friction.  MPGMC seeks to quantify such effects, and establish ‘rules’ that describe the effects of solvent on a chemical reaction by comparative studies in the gas and liquid phases.  The Bristol group has acquired a state-of-the art, ultrafast laser system for probing liquid phase reactions in real time using transient pump/probe IR and UV spectrometry.  Photodissociative and bimolecular reactions will be studied, in a range of solvents, and the results compared to those from previous and on-going gas-phase studies of the same reactions.  By observing the evolving electronic state populations (in the parent and products), and/or active vibrational modes in the products, mode-specific dynamics can be extracted and conclusions drawn about the transition state structure and the solvent’s effect on the reaction-path.  The time-dependence of the absorption spectra also provides insights into the way product internal motions couple to the degrees of freedom of the solvent bath (distinguishing, for example, interactions within the initial solvent cage an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Urban biography of a cosmopolitan African capital' in the context of a Horizon Europe call.

assistant: **Objectives**

The project aims at writing an urban biography of Tungul (Old Dongola, Sudan). The use of the native Nubian designation of the city underscores its medieval African heritage, while the “biographical” approach aids in conceptualizing the city as a complex, living organism. Tungul was originally the capital of the kingdom of Makuria which transformed into a city-state under the patronage of Funj sultans (16th–19th cent.). Makuria was a medieval African kingdom that thrived in the Middle Nile Valley from the end of the 4th cent. to the late 15th cent. CE. This project is a multidisciplinary attempt at gaining a profound understanding of settlement persistence in riverine Africa and it intends to amass extensive documentation of a medieval and pre-modern city. The biography will be based on analyses of Tungul’s urban design and planning, built structures, material culture, bioarchaeology, as well as micromorphology and geochemistry. The results will significantly contribute to the Nubian datasets and offer new perspectives for broader archaeological and theoretical studies on urbanism and complex societies. The proposed biography will focus on three entangled and mutually inclusive research themes: the capital’s cityscape, its design and planning; the city’s inhabitants; climate and environment. The project intends to venture beyond the traditional narratives, steeped in either ecological or political determinism, to create a balanced narrative devoting equal attention to climatic, environmental, socioeconomic and political factors. The majority of work will focus on the collection and analysis of data on Tungul in the Makurian period (4th–15th centuries). However, the research objectives require combining this material with data for the Funj period (16th–19th centuries), w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Structural biology tools for Antibiotic Research'.

assistant: **Objectives**

Antimicrobial resistance (AMR) is escalating due to multidrug-resistant (MDR) bacteria and a dwindling antibiotic pipeline and is projected to cause up to 10 million deaths annually by 2050. Lipid-targeting (LT) antibiotics such as daptomycin and polymyxins combat MDR infections by disrupting bacterial membranes, yet their mechanisms remain unclear due to major technical challenges for structural biology. This knowledge gap hinders the development of next-generation LT-antibiotics with improved efficacy and safety profiles.STAR will positively impact structural biology capabilities by channeling the potential of Solid-State Nuclear Magnetic Resonance (ssNMR) spectroscopy to provide atomic-level insights into LT-antibiotic interactions under physiologically relevant conditions. By optimizing the scaled production of pure, 13C/15N-labeled phospholipids, STAR will overcome key technical hurdles that have constrained ssNMR’s application in antibiotic research, dramatically boosting ssNMR sensitivity and enabling selective detection of specific lipid interactions in complex membranes. This breakthrough will allow high-resolution visualization of drug-lipid interactions of antibiotics, enabling a transformative platform to elucidate the mechanism of action (MoA) of LT-antibiotics and guide the development of potent new derivatives.To bridge a critical knowledge gap in antibiotic research, STAR will optimize the scalable bacterial production of 13C/15N-labeled phospholipids for higher yields and refine purification techniques to enhance ssNMR signal sensitivity at larger scales. Additionally, STAR will evaluate commercial feasibility and intellectual property strategies to facilitate ssNMR’s market entry. By enabling deeper molecular insights into LT-antibiotics, STAR will acc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Visualising Hibernia in Ireland, c.1770 - c.1930' (2021-2027).

assistant: **Concept**

Changing political relations between Ireland, Northern Ireland, and the United Kingdom, and the attendant prospect of a united Ireland, have given rise to lively debate within political and public spheres on the capacity of Ireland’s national symbols to represent pluralist notions of Irish identity.  Concurrently, the UK’s decision to leave the European Union has led to shifts in how Irish and Northern Irish citizens identify with the EU.  Responding to such developments, ‘Visualising Hibernia’ aims to investigate how visual representations of Hibernia, the female personification of Ireland, historically transcended political, sectarian, cultural, and religious boundaries in Ireland and thereby reveal the historic diversity of Irish identities, as well as their complex relations with Britain and Europe.  Focusing on the period from c.1770 to c.1930, ‘Visualising Hibernia’ will produce the first dedicated study of this highly significant but neglected figure in Irish cultural history and Anglo-Irish political relations.As an inherently classical figure, Hibernia has typically been perceived as the ‘non-native’ embodiment of Ireland adopted by the country’s eighteenth-century ‘Protestant Ascendancy’ ruling elite or as fodder for nineteenth-century British political cartoonists. ‘Visualising Hibernia’ complicates such perceptions by foregrounding how groups across the Irish political spectrum employed the personification in the period c.1770-c.1930, ranging from a Protestant minority seeking self-governance under the British Crown to Catholic and radical republicans or Anglo-Irish cultural nationalists. It will be conducted under the supervision of Prof. Lynda Mulvin, an expert on classical antiquity and its reception, at UCD, a leading institute for research on Irish poli