RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Expression and neuro-protective function of latent transforming growth factor binding proteins in the central nervous system of Rodent and Human' to be submitted under Sixth Framework.

assistant: **Abstract**

Transforming Growth Factor ßs (TGFßs) regulate the formation of the extracellular matrix and the growth and differentiation of various cell types in different organs. Latent TGFß Binding Proteins (LTBPs) are needed for secretion, correct folding and matrix deposition of TGFßs. In the brain, TGFß1 is inducible by ischemia, while ß2 and ß3 are present constitutively in several regions. Strong evidence indicates that TGFß1 has neuroprotective functions. The role and the distribution of LTBPs in the brain are unknown. We assume that the four known members of LTBPs also play a role in the processing of TGFßs in the nervous system. Preliminary in situ hybridisation studies clearly show that LTBPs are present in the rat brain.High LTBP1 expression levels are seen in the medial preoptic area, the anteromedial thalamus and some cortical regions. LTBP2, an exceptional member of the LTBP protein family (no binding to TGFßs) is expressed only in cortical areas, hippocampus, and the perifornical/dorsolateral hypothalamus. LTBP3 exhibits a wider expression profile with the strongest expression in the ventral pallidum, anterodorsal and reticular thalamic nuclei, hippocampus, cortex, red nucleus and the periaqueductal gray.The objective of the application is to initiate a research project on the distribution and function of LTBPs in the brain based on these new preliminary data and my background in histology and molecular biology. Apart from identifying the cells and brain regions that express LTBP-s in rat and human the role of this protein family in endogenous neuroprotective mechanisms will also be investigated using experimental ischemia models in rodents as well as post mortem brain samples of stroke patients. Altogether, this application can provide the foundation for a long-term
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Extended fluorescence resonance energy transfer with plasmonic nanocircuits' in the context of a Seventh Framework call.

assistant: **Objectives**

Förster fluorescence resonance energy transfer (FRET) is one of the most popular methods to measure distance, structure, association, and dynamics at the single molecule level. However, major challenges are limiting FRET in several fields of physical and analytical sciences: (i) a short distance range below 8 nm, (ii) a concentration range in the nanomolar regime, and (iii) generally weak detected signals.At the interface between physical chemistry and nano-optics, the proposal objective is to extend the effectiveness of single molecule FRET using plasmonic nanocircuits to: (i) perform FRET on a range up to 20 nm, (ii) detect a single FRET pair in a solution of micromolar concentration, and (iii) improve the statistical distribution in FRET measurements.To meet its ambitious goals, the proposal introduces plasmonic nanocircuits to tailor the light-molecule interaction at the nanoscale. Energy transfer between donor and acceptor fluorophores is efficiently mediated through intense surface plasmon modes to extend the FRET distance range and improve the fluorescence signal. Moreover, the nanocircuits will be combined with recent innovations in biophotonics: stimulated emission of acceptor fluorescence, full dynamic analysis, and fluidic nanochannels.The scientific breakthroughs and project impacts will open new horizons for proteomics, enzymology, genomics and photonics. For elucidating molecular structure, the long range FRET will enable understanding the folding structure of large DNA or protein molecules. For assessing chemical reactions, achieving single molecule analysis at micromolar concentration is essential to monitor relevant kinetics, reveal sample heterogeneity, and detect rare and/or transient species. For analytical chemistry, nanocircuits are ideal for sensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Open Collaboration in Policy Modelling' in the context of a Seventh Framework call.

assistant: **Objectives**

OCOPOMO addresses two levels of scientific and technological advancements:1)\tSocio-political: to formulate, model, evaluate and monitor social and economic policies of governments, which are supported by2)\tScientific and technological innovations: drawing together lessons and practical techniques from complexity science, agent based social simulation, foresight scenario analysis and advanced ICT for e-participation.OCOPOMO develops an integrated IT platform for efficient policy development by integrating formal policy modelling, scenario generation, and open collaboration supporting engagement of wide stakeholder groups in social and economic policy areas of two pilots. The project builds on methods and tools of policy modelling and scenario-based foresight and integrates them into a platform of open collaboration among key stakeholders (policy analysts, policy operators, wider interest groups of specific policy domains, etc.) using e-participation tools.The outcomes of OCOPOMO are:a)\tIT solutions (e-governance toolbox) supporting the engagement and open collaboration of participating stakeholders in collaborative scenario-development and in reflexive discussions about resulting formal policy models;b)\tA general model of macroeconomic relations deduced as much as possible from data available at national and European level, and enriched with the commonalities deduced in the two pilot policy areas;c)\tTwo policy analyses related to the strategic economic and social development policies in regions in Italy and Slovakia. The policy analyses will be based on both formal simulation models and narrative scenarios;The policy analyses are generated with the precision and clarity of formal models and rich contextual narrative scenarios resulting from the combination of scenar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantification of ecological services for sustainable agriculture' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The project aims to identify the key semi-natural habitats (SNH), outside and within crops, providing essential ecological services (ES). Vegetation traits will be linked to potential ES provision, case studies will measure actual ES levels and inform models which will show unused opportunities and trade-offs among ES by SNH from habitat to landscape scale. This will be achieved for a range of representative cropping systems and farming intensities in regions dominated by agriculture and matched to the requirements of local and national stakeholders. Surveys will identify key SNH and existing literature will be used to link their vegetation traits to ES provision. ES provision will be measured in existing habitat types (SNH to crop) across economically important cropping systems, farming intensities and four European agro-climatic zones using simple techniques in 16 case studies. A case study is defined by a unique combination of region, crop species, and service. Each case study will concentrate on locally important cropping system and the main ES required. Pollination and pest control have been identified as main ES needed, but also soil fertility, weed control and social services will be considered. The relative socio-economic weight of the studied ecosystem services will be appraised using feedback from national experts using a semi-quantitative method. Data will parameterise spatially explicit models to determine how the vegetation composition, management, shape, area, and placement of SNH in agricultural landscapes affect the distribution of mobile-agent based ecosystem services from farm to landscape level. To investigate synergies and trade-offs in ecological services, multi-criteria analysis will be developed to combine a suite of modules in an integrative mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Continuous Industrial Process for the Recycling of the Active Salts and Water in Galvano Processes' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The general objective: the investigation and the development of an economic acceptable continuous and automatable industrial process, using ion exchange membranes, resins and electricity, for the recovery of the active salts from the rinsing water of galvano processes, the recycling of the purified water to the galvano reactor and rinsing basins, hereby severely reduces the process water consumption, increasing the safety and preventing the spoilage of hazardous materials in the environment. Specific objectives: * identification of applicable resins and ion exchange membranes for the separation of the salts and the water, and establishment of their efficiency and characteristics; * validation of the technical and economic effectiveness of the newly developed process over existing processes. It is estimated that through recycling, the total volume of water consumption will decrease 4 to 5 times; * reincorporation of the recovered salts in concentrated form in the manufacturing of the galvano salts; * development of a methodology for the quick evaluation of ion exchange membranes and resins as a function of the galvano process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Assessment and mitigation of nano-enabled product risks on human and environmental health: Development of new strategies and creation of a digital guidance tool for nanotech industries' (GUIDENANO), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of GUIDEnano is to develop innovative methodologies to evaluate and manage human and environmental health risks of nano-enabled products, considering the whole product life cycle. A strategy to identify hot spots for release of nanomaterials (NMs) will be followed by decision trees to guide on the use of (computational) exposure models and, when necessary, design of cost-effective strategies for experimental exposure assessment. These will include on-site and off-site monitoring of industrial processes, use, accelerated aging, recycling and disposal set-ups. In all cases, there will be a strong emphasis on the transformation of NMs. Similarly, a tiered strategy to evaluate the environmental fate and the hazards for ecosystem and human health of NMs will be developed. The project will consider pristine synthesized NMs, transformed NMs released during the life cycle of the product, and interactions of the NMs with other substances in their host matrices and ubiquitous pollutants. The project will also develop innovative solutions to reduce identified risks. These will include safer-by-design approaches (to reduce NM hazard, reduce migration and release, or accelerate degradation when released), new technological solutions for exposure control measures, and solutions for waste minimization and treatment.These developments will be incorporated into an web-based Guidance Tool, which will guide the nano-enabled product developers (industry) into the design and application of the most appropriate risk assessment & mitigation strategy for a specific product. The correct implementation of this guidance will ensure that the risks associated to a nano-enabled product, throughout its whole life cycle, have been appropriately evaluated and mitigated to an acceptab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Providing the New Generation of Nano-Based Molecular Technology for the Early Detection of Bacteria, Viruses and Cancer at the Point of Care' in the context of a Horizon 2020 call.

assistant: **Objectives**

There is a need for cost-effective molecular point of care diagnostic tools to provide better healthcare to patients and better agility to our healthcare system. And what about going one step further by extending the limits of molecular diagnostics to the nano-scale?We have developed the nano-technology-based solution nano4. nano4 is a fast and user-friendly nano-based diagnostic technology suitable for use at the POC. nano4 represents a highly specific and sensitive nanotechnology for in vitro molecular diagnostics. nano4 uses gold nano-probes to recognize the complementary DNA/RNA strand and yield a color output that allows for quick decision making.Our ultimate objective is to leverage the diagnostic possibilities of nano-technology for all its applications in medicine and life science, thereby expanding the current possibilities of molecular analysis. We are convinced that the fast, accurate, low-cost and user-friendly diagnostic of certain viruses, pathogens and cancer-types through nano4 will help healthcare decision-makers to act quickly, thereby saving lives, pain, mistakes and even preventing epidemics. Our business objective is to make nano4 a standard POC diagnostics technology present at each POC globally and to become the global leader in nano-based molecular diagnostic technology.Easily accessible fast molecular testing is a tremendous challenge especially when reliable results are needed quickly and cost-efficiently. Especially now, with the migrant crisis, cases of TB and Zika are more frequent. Each application of nano4 can answer a specific European challenge.We will conduct several activities including production process analysis, cost-benefit analysis, partner search, market research, customer validation activities, price acceptance analysis, focus g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Human-Centric Energy Districts: Smart Value Generation by Building Efficiency and Energy Justice for Sustainable Living', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The EU has used the Strategic Energy Technology Plan to transfer power to consumers, by decentralising the energy eco-system by establishing “100 positive energy districts by 2025 and 80% of electricity consumption to be managed by consumers in 4 out of 5 households”. The SMART-BEEjS recognises that this requires the systemic synergy of the different stakeholders, balancing attention towards technological and policy oriented drivers, citizens and society needs, providers and technology capabilities and value generation system synergies in order to deliver the transition without leaving large parts of the population behind. Smart-BEEjS covers all angles of this eco-system, to train a generation of transformative and influential champions in policy design, techno-economic planning and business model innovation in the energy and efficiency sectors, mindful of the personal and social dimensions, as well as the nexus of interrelation between stakeholders in energy generation, efficiency and management. Five objectives have been set to develop:•a practical tool that popularises the evidence based knowledge of the relationships between socio-economic factors and citizens’ practices, enabling citizens to become active promoters of PEDs;•strategies that can positively influence citizens towards sustainable behaviour patterns, which will be used to advise at city/town council level;•a methodology for systemic planning of infrastructure investments that can be recommended at city/town level in order to transition towards PEDs, by designing a systemic modelling approach combining techno-economic aspects and pathways toward the creation and sustainability of PEDs;•an evidence-based policy and incentives pathway for tackling energy injustice and poverty, by an effective design of pol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High-order moment models and multi-scale numerical methods for plasmas applied to electric propulsion' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

We are in the midst of a technological revolution characterized by the large demand for small satellites. These satellites are cheaper to launch and allow for forming constellations, impossible with larger satellites. As a result, they require propulsion systems in order to control their trajectories. Electric propulsion (EP) largely reduces the operational costs, using less propellant, precisely controlling thrust, and operating for long times. The response to the demand for EP is currently at stake because of two reasons: 1) Most of the thrusters operate with an expensive and scarce propellant gas, xenon, and 2) The development of the engines follows an empirical approach that is long and expensive, which limits the optimization and conception of new prototypes. These limitations are due to the lack of models that capture the complex plasma physics in EP, in particular: 1) The impact of the plasma composition and thruster geometry on the performance, 2) The presence of multi-scale plasma kinetic instabilities, and 3) The erosion of the walls interacting with the plasma. Our objective is to develop advanced predictive plasma models, able to help to the conception of new thrusters operating with cheaper propellants, improving their stability and performance, and predicting their lifetime, without the need of expensive experimental campaigns. We will follow a multidisciplinary approach, integrating physicist, engineers, chemists, and applied mathematicians. Our methodology aims at extending the classical fluid equations by solving for higher-order moments, allowing to describe in an efficient manner microscopic (kinetic) processes. With advanced numerical techniques, we will propose multi-scale models able to describe the turbulent phenomena, the wall processes, and effi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hybrid Nanosystems in phospholipid membranes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The cell membrane is the biological platform for many vital processes such as photosynthesis, cell-cell contact, biomolecular recognition, endocytosis and ion transport. Artificial phospholipid membranes play an important role in unravelling the physical and chemical characteristics of membranes and their microscopic role in membrane function. On the other hand a manifold of novel hybrid nanosystems consisting of different nano-objects and exhibiting specific physical and chemical functions have been developed. This proposal aims at incorporating hybrid nanoparticle systems with specific optical functions into artificial and cell membranes in order to build up a nanophotonic toolbox for nanoscopic optical manipulators, local spectroscopic studies and the combination of both. This nanophotonic toolbox for membranes will open up novel strategies for the optical control of membrane function, the controlled optothermal release and lateral guiding as well as the local spectroscopy and analysis of biomolecules. The planned toolbox also contains new optical concepts for transfection and drug delivery.