RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Control of cell shape in the peripodial membrane of the wing disc of Drosophila melanogaster' under Seventh Framework.

assistant: **Concept**

I propose to analyze how epithelial cell shape is controlled, using the Drosophila peripodial membrane as a model system. Drosophila third instar imaginal discs are a composed of two contiguous layers of cells of distinct morphology: a pseudostratified one, called the proper epithelium (PE), and a squamous epithelium, the peripodial membrane (PM). While the PE has been deeply studied, little is known about the PM. The peripodial membrane has the ability to change its shape in response to ecdysone; it is proposed that this change is responsible for the eversion of the disc during metamorphosis. I propose to study the control of cell shape in the PM by two perspectives. First, I will look for the factors involved in specifying and maintaining the shape of the PM cells. Second, I will examine the dynamic process of disc eversion, and analyse what shape changes the cells undergo, and what factors and cellular rearrangements are responsible for this fundamental morphological process. For this purpose I have developed a technique that allows me to watch dissected live discs, and to follow the eversion in vitro using confocal live imaging. Amongst other mechanisms, I am currently analysing the role of myosin II in this process as well as looking for new factors that may be involved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimization and data aggregation for net-zero power systems' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

One of the fundamental problems of using optimization models that represent complex systems – e.g. power systems on their path towards achieving net-zero emissions – is the trade-off between model accuracy and computational tractability. Many applied optimization models that use different time series as data input have become increasingly challenging to solve due to the large time horizons they span and the high complexity of technical constraints with short- and long-term time dynamics. To overcome computational intractability of these optimization models, the dimension of input data and model size is commonly reduced through time series aggregation (TSA) methods. However, applying TSA for optimization models that are governed by varying time dynamics simultaneously is quite challenging. TSA methods mostly focus on short-term dynamics, and rarely include long-term dynamics due to the inherent limitations of TSA. As a result, longer-term dynamics are not captured well by aggregated models, which is imperative for reliably modelling many complex systems. Moreover, traditional TSA methods are based on the common belief that the clusters that best approximate the input data also lead to the aggregated model that best approximates the full model, while the metric that really matters –the resulting output error in optimization results – is not well addressed. This belief is mainly based on the lack of theoretical underpinning relating inputs and output error, rendering existing methods trial-and-error heuristics at best. We plan to challenge this belief by discovering the currently unknown relation between input and output error, and to overcome existing TSA shortcomings by developing the novel theoretical TSA framework for optimization models with varying time dynamics, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Repurposing clinically approved antibacterial drugs for treponematoses therapy'.

assistant: **Objectives**

Current therapeutic options for human treponematoses, syphilis and yaws, are, broadly speaking, restricted to one antibiotic: injectable penicillin. The drug susceptibility profile of Treponema pallidum (T.p) is unknown because the microorganism could not be grown in culture. Treatment failure after penicillin has been related to syphilis bacteria that survive in the central nervous system (CNS) and the potential of strains to acquire resistance to penicillin has recently been recognized. Yaws can be treated with azithromycin but there is a real risk that macrolide-resistant strains disseminate widely and jeopardize the global eradication campaign. I propose a research program to have other validated treatment options with good CNS penetration that are efficacious for all the stages of treponemal infection. Our preliminary results using computational prediction of drug activity based on similarity to drugs with known activity against T.p. and other spirochetes shows several candidate antibiotics. I will take advantage of recent developments in culture methods for determination of drug susceptibility to test 20 prioritized drugs. These results will be confirmed in experimentally infected rabbits treated with the investigational drugs and assessed for lesion development and T.p. burden. My second approach will exploit the established expertise of my team conducting randomized clinical trials to evaluate the efficacy of the 2 most promising candidates compared to standard treatment to cure patients with syphilis/yaws. Such studies will incorporate in-depth studies of recurrent events among study participants, to further clarify the biological basis and identify mutations that confer resistance to B-lactams. New antibacterial oral drugs for the treatment of treponematoses w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PROTECTING AND RESTORING BIODIVERSITY USING MAINSTREAM FINANCE (BIOFIN)', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

If biodiversity is to be placed back on a path to recovery, new tools and knowledge are required to redirect financial resources from destructive economic activity towards nature-positive investment. The financial system consists of interacting and dynamic actors who value certainty (rules and governance structures) and efficiency (outcome transparency and low monitoring costs). We aim to create a unifying framework and technology that creates the enabling conditions for nature-positive investments. Activities that protect and restore biodiversity (such as nature-based solutions) are frequently unique, multi-actor efforts carried out at a local scale with positive, but complex outcomes. We resolve this by establishing a categorisation of nature based solutions (NBS) alongside a menu of good governance structures and a library of stakeholder engagement. This will draw on expertise and best practice in natural capital and economics to streamline decision making and accelerate transaction completion by standardising the investment process and creating the enabling conditions for large-scale finance. To accelerate nature-positive business models, we create a data analytics and underwriting engine to advance conventional project appraisal and risk assessment and account for and model expected outcomes. We will assess and validate our approach across diverse real-life case studies (learning sites). Our findings and approach will initiate a twin green and digital transition that resolves transaction complexity and creates the enabling conditions for large-scale investment that are required if the EU is to achieve its biodiversity goals. Our outcomes will identify remaining gaps in the Taxonomy and support policy forming through evidence-based recommendations and we will co-des
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Computational optimization methods in Statistics, Econometrics, and Finance'.

assistant: **Objectives**

The scope of quantitative research broadens due to the increasing availability of large data sets. In order to extract relevant information new statistical procedures are developed. Often, these procedures result in complex optimization problems which cannot be tackled by standard algorithms. Thus, there is an urgent need for the further dissemination of recent advances in heuristic optimization. These tools are still rarely used in statistics, econometrics, and quantitative finance. This neglect is due to missing information about the complexity of the problems, missing knowledge about the tools, and a missing standard for the analysis of the additional stochastic component introduced. COMISEF will close these gaps by consolidating European research activities and by providing a research training framework for young scientists. COMISEF will generate synergies between researchers from different disciplines and overcome the fragmentation of the European Research Area. It will bundle resources to establish a new optimization paradigm in statistics, econometrics and finance. COMISEF focuses on new optimization methods, their implementation (including parallel, distributed, and grid computing), their applications in statistics, econometrics and quantitative finance, and the statistical analysis of procedures and implementations. A cohort of young scientists will acquire the relevant knowledge for the development and implementation of innovative computational tools. These experts are required in academia and in industry in Europe, e.g., in the finance and related sectors. Thus, educating these experts will provide European value added. Based on the scientific results, in particular a well established formal framework for the analysis of convergence of optimization heuristics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced quality prediction tool for knowledge-driven packaging design and manufacturing in European SMEs' to be submitted under Sixth Framework.

assistant: **Abstract**

This proposal aims at improving the international competitiveness of European corrugated board industries, which are mainly SMEs and of related sectors by an integrated, transnational research approach. Research will be carried out by RTD performers in order to expand the knowledge base and improve the overall competitiveness of participating SMEs. It shall enable SMEs to increase their added-value in producing corrugated board, being one of the most valuable packaging materials, from alternative resources with high proportion of recycled fibers. For the European corrugated board industry the variability in raw materials with increasing percentages of recycled fibers is a very common technical problem.Overall scientific and technical objectives: To create a database of information on raw materials (grade papers and corrugated board) available for packaging companies throughout Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Low-Cost Metasurface Leaky-Wave Antenna for Mobile Satellite Communications' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

With the increasing demand of broadband connectivity, satellite communications are receiving significant attention, since the requirement for infrastructure in Earth is minimum. However, broadband low-latency satellite connectivity entails several challenges from the point of view of radiofrequency engineering: antennas with high gain, beam steering capabilities and broad bandwidth are required. Current solutions are either parabolic dishes with mechanical steering, which are bulky and require maintenance, or phased- arrays with electronic steering, which are low-profile but significantly expensive. Therefore, a reconfigurable low-cost high-gain antenna with no moving parts and small size is an important market niche and can revolutionize satellite communications. In this way, the current limitations of connectivity to mobile users, such as in maritime or aviation, or in isolated or poor areas, where expensive infrastructure cannot be deployed, can be overcome.The project proposes a novel low-profile and low-cost solution for broadband satellite communications based on the fusion of two fields: metamaterials and leaky-wave antennas. By combining such an inexpensive antenna with a metasurface, the antenna characteristics can be enhanced to meet the challenging requirements of satellite services at a very low cost and size. The researcher will have the opportunity to learn this cutting-edge technology from the pioneer group in this kind of solutions at University of Toronto,and import this knowledge into Europe to contribute to developing the satellite communication industry and open new markets. Moreover, the knowledge of the group at the University of Malaga (including the researcher) about both broadband leaky-wave antennas and active components will be crucial to deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Grammar of Inclusion: Exploring the Boundaries of Linguistic Competence' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The combination of phrase-structure syntax and model-theoretic semantics have led to a powerful, general model oflanguage. However, previous research has not sufficiently explained how syntactic structure and structural differencesacross languages relate to mathematical operations on meaning: some constraints observed in the language implementationof these operations are a consequence of the language form, while others can come from human reasoning processes,beyond language. This project investigates this domain from the perspective of partitives and the formal subset relation.Nominal partitives as 'two of the beans' explicitly express the subset relation in English. Other Romance and Germaniclanguages have similar, but not identical forms: e.g. in German genitive case can be used. Pseudo-partitives like 'two cupsof beans' share many of the lexical items of partitives, so if structure and meaning are projected from lexical items, bothneed to be considered in parallel. Partitives are interestingly more constrained than the subset relation. For example, theyexpress only proper partitivity: 'Two of her parents' is odd. We explore the boundaries between linguistic competence andother cognitive systems, with one leading question: what is the source of these constraints? We adopt the methodology ofsyntax and semantics, with an experimental component. The issue is addressed pursuing three goals: i) on the basis ofsyntactic cross-linguistic variation, we build a syntax/semantics for partitives; ii) we establish which constraints come aboutfrom the format and from standard interpretation rules; iii) we specify pragmatic or other general cognitive limitations in theprocessing of the subset operation.The project contributes to integrate syntax and semantics with the cognitive scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Science PlAtform Cloud Infrastructure for Outsize Usage Scenarios', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The SPACIOUS project aims to boost the scientific exploitation of ESA mission data by offering a new computational framework for astrophysical research that requires Big Data and Data Mining technologies to be employed. SPACIOUS will raise the competitiveness of the EU scientific community by increasing the Big Data and Data Mining expertise and providing easier access to these techniques.To reach this goal SPACIOUS aims to combine existing technologies in a new Data Mining environment to enable the analysis of ESA missions’ data up to a level which is not possible without a dedicated infrastructure. The ambition of SPACIOUS is to open this platform to the community, while at the same time exploiting the data by developing astrophysical research, in collaboration with external scientific teams.The main idea is to facilitate and open the analysis of ESA archives to the scientific community in new ways. SPACIOUS will make the difference by providing access to the data and, at the same time, providing the infrastructure, tools and methods to analyse these data. SPACIOUS will be the tool enabling Big Data analysis of ESA data products. Furthermore, we expect SPACIOUS to make a change by influencing the future way to treat data in space science.A key part of the project is to produce scientific value (publications, enhanced data products and knowledge). We will face major scientific research data problems (challenges) whose analysis will be, per se, a key result of SPACIOUS. Four of these challenges will be defined internally (based on the exploitation of the massive Gaia and Euclid datasets) and used to drive the design requirements of the system, serving as test cases and technology demonstrators of the Big Data Analytics Framework (BDAF). In a second phase we will open th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'In vitro brain microvascular model to tackle fever in cerebral malaria' (FEBRIS) targeting Horizon 2020.

assistant: **Abstract**

Malaria still claims more than 400,000 deaths every year, above all in children under 5. All symptoms are caused by the blood stage of the deadliest parasite species Plasmodium falciparum (Pf), which infects human red blood cells. Cerebral malaria (CM) is the most severe complication, with 20% mortality rate even after administration of fast-acting antimalarials, and is due to build-up of parasites in the brain microvasculature leading to vessel occlusion, blood-brain-barrier disruption, and brain swelling. Current knowledge of CM is based primarily on autopsy analysis, because of limitations of suitable animal models, where disease onset and progression cannot be studied. Additionally, different areas of the brain with distinctive vascular patterns show CM-specific lesions supporting the hypothesis of different regional microcirculations. In my project FEBRIS I will tackle, for the first time, human CM process in vitro models of white and grey matter, and basal ganglia, with cutting-edge bioengineering approaches. I will develop 3D microfluidic devices coated with endothelial cells mimicking vessel networks and physiological flow rates of these three regions of the brain. Numerical simulations will identify critical factors causing blood stagnation, predicting where and when a clog could form. Using this technology brings a unique angle to malaria research to systematically evaluate the unexplored effect of fever on molecular and biophysical mechanisms of Pf sequestration, and the concurrent vascular damage. The obtained findings will be validated with parasites from the field and brain samples from CM patients, examined with pioneer 3D autopsy imaging. This interdisciplinary approach, favoured by my host, aims to provide a holistic understanding of CM pathogenesis. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Trade, societies and sustainable development - sustra.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The Seattle failure has demonstrated the urgency for Europe to make new sustainable trade policy proposals in the World Trade Organisation. Such proposal will have to be consistent, credible and legitimate both with respect to Europe's trading partners and with respect to its domestic civil society. The network gathers European economists, sociologists, law specialists and political scientists who will collaborate, together with NGOs and European policy-makers, to analyse the following interrelated themes:the use of the global public good concept to analyse the interdependencies between economic and sustainability objectives in trade; the legitimacy of sustainable impact assessment procedures; the architecture of the international institutional system governing trade and sustainability;the political acceptability of trade reforms within Europe;and the civil society participation to the trade decision-making process within Europe.