RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Grapevine genetic Transformation to study gene function' (GRAPEGENFUN) under Sixth Framework.

assistant: **Objectives**

Grapevine genetic transformation is a potential tool for both functional genomics and molecular breeding projects. Genomic resources of grapevine have been very little exploited and little is known on grapevine biology at the molecular level. Here we focus on the development of the methodology for efficient transformation of European cultivars to study gene function. There are three key points to approach grapevine transformation: The ability to produce plant tissue competent for transformation and regeneration, the choice of the quick method for transformation and regeneration and the design of DNA constructs for transgene integration. Anthers and ovaries will be used to initiate embryogenic cell suspensions, which will be assayed with novel cryopreservation techniques for keeping long-term regeneration capacity. We will select the biolistic device as strategy for transformation because of the advantage of the genegun for grape transformation avoiding the use of Agrobacterium, which causes hypersensitive reaction in grapes.Whole circular plasmids will be compared to the novel minimal linear cassette technology for over-expression and silencing strategies of target grape genes. In this proposal, we will focus on grape genes involved in flower transition. We wi ll over-express VFL under control of the 35S-CaMV promoter as a possible strategy to reduce flowering time as well as the over-expression of the mutated VvGAI gene to obtain early flowering plants producing only inflorescences. We will approach the novel RNA interference (RNAi) technology as a tool for functional genomics studies by using the VAP1 gene, which silencing could affect tendril development. We expect to see early in vitro the effect of the expression strategy on the phenotype of recovered transgenic pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Curved nanomembranes for Topological Quantum Computation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Topological quantum computation, based on the encoding of quantum information in non-local degrees of freedom, provides a promising route for a working quantum computer not affected by quantum decoherence. A possible way of realizing this non-locality is to encode qubits into so-called Majorana fermions - quantum particles that are their own antiparticles. As an elementary particle, Majorana fermion is a hyphotetical object. However in condensed matter it can be built out of what nature offers us: electron and hole excitations. Recently a number of experimental setups have been proposed to support Majorana zero modes, among which are planar superconductor-semiconductor heterostructures and superconductor-topological insulator hybrids. Despite the fact that such solid-state-devices consist of rather conventional" building blocks, the actual experimental observation of Majorana fermions is still the biggest challenge in the field. The experimental difficulty stems from a required, very delicate fine-tuning of intrinsic materials parameters, e.g. strength of the Rashba spin-orbit coupling, and external physical quantities, e.g. strength of externally applied magnetic fields. The aim of CNTQC is to overcome these hurdles by designing, fabricating and testing novel platforms where strong curvature-induced quantum effects can generate the requirements of the Majorana fermion's cocktail in a controlled manner. The pursued approach will exploit modern nanostructuring technology to transform very thin nanomembranes into three-dimensional nanoarchitectures with a strongly curved geometry. The combined experimental and theoretical understanding of the geometrically-induced topological superconducting state aims to pave the way towards a direct demonstration of the existence of Maj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Physiological and environmental controls of water and ozone fluxes in a short rotation poplar plantation: from leaf to tree to ecosystem scale.' (PHYSIO-POP).

assistant: **Concept**

One of the consequences of global climate changes is the altered global water availability. Among the greenhouse gases (GHGs) causing global climate changes, carbon dioxide (CO2) has received most attention. Over the last decennia the impact of rising CO2 concentrations on crops has been widely studied. The study of tropospheric ozone (O3) and its consequences on crops has not been as extensive, although O3 is a widespread and damaging air pollutant in industrialized countries. The PHYSIO-POP project fits within the search for renewable (bio-)energies, in particular the production of woody biomass energy. The project will examine the water consumption and the sensitivity to O3 pollution of a short rotation poplar plantation with fast-growing poplars (Populus spp.) for biomass production.The multidisciplinary and interdisciplinary approach followed by this PHYSIO-POP proposal aims to improve our knowledge of the impact of global climate change by studying the physiological and environmental controls of water and O3 fluxes in different short rotation poplar genotypes at all relevant biological (leaf, tree, ecosystem) and time (daily, seasonal) scales. To achieve this objective the project makes the unusual combination of plant (eco-)physiological studies at the leaf and the tree levels with model simulations at tree and ecosystem levels to improve our understanding of what happens at the whole plantation, from the leaf to the ecosystem scale over the individual tree level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'FluorineID: Bridging identity and quantity – Unraveling the unknown fluorine content in environmental samples via quantitative non-target screening (qNTS)' (FluorineID).

assistant: **Concept**

Per- and polyfluoroalkyl substances (PFAS) encompass potentially millions of synthetic compounds that are widely used in modern society. These “forever chemicals” are extremely persistent, harmful to health, and are widespread globally. Despite advancements in their analysis, high levels of unknown fluorine—termed “PFAS dark matter”—persist in the environment, indicating that most fluorinated compounds remain unidentified. ""PFAS dark matter"" can originate not only from PFAS but also from many other emerging fluorinated compounds, including ionic liquids. Cutting-edge non-target screening (NTS) with high-resolution mass spectrometry (HRMS) can detect thousands of chemicals like PFAS but is typically only qualitative and limited in scope. FluorineID aims to address this gap and to unravel the “PFAS dark matter” by developing computational quantitative NTS (qNTS) methods that (1) integrate key chromatographic separation platforms for broader chemical space coverage, (2) prioritize the millions of fluorinated compounds in the online database PubChem for efficient and comprehensive identification, and (3) apply machine learning to quantify fluorinated compounds. The combination of individually identified and quantified fluorinated compounds with total fluorine measurements will allow verification via fluorine mass balance approaches. FluorineID will advance the identification and quantification of unknown fluorinated compounds, support identifying the origin of unknown fluorine in the environment, and offer open source qNTS workflows to accelerate future community-wide identification and risk assessment of “PFAS dark matter”.""


**Keywords:** Quantitative Non-Target Screening (qNTS), High-resolution mass spectrometry (HRMS), Per- and polyfluoroalkyl substances (PFAS), Flu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transfer and adaptation of a knowledge formalisation technology to SMEs management' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The project aims at demonstrating - through real cases - how with the support of the SME associations it is possible in an effective way to transfer to SMEs - adapting and modifying it - a technology for knowledge formalisation already tested in the field of clinical medicine and, above all, in the big firms, so as to make it possible to set-up or re-engineer at all instruments based on information and communication technologies useful, on the one hand, for identification, focalisation and strengthening of the crucial processes (those connected with the distinctive expertise that justifies the positions or competitive advantage) and on the other, the determination and externalisation of non-crucial activities from a standpoint of improving efficiency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Alternative Water Resources and Deliberation process to renew water supply strategic planing' (AWARD) targeting Horizon Europe.

assistant: **Abstract**

AWARD recognises the urgency of action due to water scarcity and climate change impacts as well as the need to engage simultaneously the society, the science and the policy into the development of knowledge and strategic water planning. Therefore, AWARD will provide evidence-based solutions to consider AWRs into water supply strategic plans, based on socio-political engagement. The 4 Demo Cases of AWARD are already implementing AWRs (storm water, rainwater and aquifer recharge in Bucharest in Romania as well as in Milano in Italy; water reuse in Cyprus, storm water and rainwater in an industrial park in Santiago di Compostel in Spain). Through the project activities, Demo Cases will consider scaling up their actions taking in account a broader range of AWRs together with conventional water resources for planning future water supply systems at local or regional level using AWARD instruments (Local Water Fora, Digital Platform for decision making, training and guidance). They will address similar issues in a harmonised and coordinated way. Societal awareness to support the decision process on AWRs supply solutions will lead to the recommendations for further use of AWRs encompassing the 4 dimensions of social innovation (Technological, Capacity development, Governance & Policy, Economics & assessment). The AWARD AWRs catalogue will gather the project results and additional solutions which will be benchmarked. The digital platform provided by AWARD will support the exploration of resilient scenarios that will be promoted beyond the scope of the project thanks to dedicated networking activities.AWARD general objective is to provide evidence-based knowledge and lessons learnt on how to effectively integrate affordable, acceptable and reliable AWRs solutions into water supply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Galleries universal information, dissemination and editing system', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The GUIDE project aims at establishing Europe as the world leader in the use of Portable Digital Assistants for museum visitors to not only enrich the visit experience but also to enable them to take away a Personal Catalogue in attractive paper form (or an electronic version) containing only the information they require on objects or themes of particular interest to them, with an emphasis on the use of narratives to stimulate and educate and entertain them as well as encouraging repeat visits - either in person or increasingly over the 'Infobahn'. The latter is seen as complementary to the GUIDE PDAs since it is increasingly clear that electronic visits are no adequate substitute for the actual visit, except for disadvantaged people, and indeed there is emerging evidence that electronic visits lead to higher numbers of 'physical' visits.The GUIDE approach is to combine two innovative systems already pioneered by the developer SMEs in the Consortium: 1. A portable device enabling the visitor during the visit to select its objects and themes of interest and then obtain a Personalised Catalogue. An early prototype has already been developed in the special East German VAMP project supported by ESPRIT. 2. Digital Audio Guides pioneered by GUIDE SMEs in Italy, Spain and the UK. GUIDE will be driven by the requirements of its museum partners to provide greater value to their visitors, the Consortium including not only two museums already taking a leading role in the application of new technologies in the museum field - the Jewish Museum of Vienna and the National Museums of Scotland, plus a special GUIDE Tuscany Museums User Group, co-ordinated by the University of Florence, building on its similar previous work with the Uffizi in a number of EC supported projects, as well as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cell-specific vascular protection by CXCL12/CXCR4' (PROVASC) targeting Horizon 2020.

assistant: **Abstract**

Cardiovascular disease including coronary heart disease remains the leading cause of death worldwide. Atherosclerosis as the underlying pathology is a lipid-driven inflammatory disease of arteries giving rise to vulnerable lesions prone to rupture and thrombotic occlusion. Lesions develop at predilection sites with disturbed flow, where endothelial damage promotes intimal retention of lipoproteins and inflammatory leukocyte recruitment. Past research has largely focused on atherogenic factors and their inhibition but not on boosting a counterbalance by protective mechanisms. We have recently found that the CXCL12/CXCR4 chemokine-receptor axis protects against atherosclerosis by controlling neutrophil homeostasis and facilitating endothelial regeneration in mice. This is supported by genome-wide association studies, identifying genetic variants near CXCL12 associated with the risk of coronary heart disease. The protective regulation of endothelial repair by microRNAs also involves CXCL12/CXCR4. However, the causal and cell-specific impact of this axis remains unclear.To balance the ongoing expansion of genetic risk variants, PROVASC aims to discover/elucidate novel mechanisms for protective cell homeostasis and regeneration counteracting atherosclerosis in depth. To this end, we will dissect cell-specific effects of the CXCR4-CXCL12 axis using an array of mouse lines for conditional deletion and bone marrow chimeras to compare resident versus hemato-poietic cell compartments. We will validate a role of coding and non-coding genetic risk variants affecting CXCL12/CXCR4 in different cell types and humanized mouse models. By identifying relevant microRNAs targeting CXCL12/CXCR4, we will unravel a regulation of this axis by cell type-specific microRNAs. Given the ubiquitous
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Design Challenge Pilot' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The aim of the project is to enhance the co-creation philosophy to the service delivery system of urban challenge solving, through the inclusion of innovative SMEs in the design process. During the implementation of the project, the partners will peer review a co-creation procedure of setting up a solution that addresses a local challenge, satisfying the affected target group, capitalizing the expertise of the innovative SMEs of the region/country and enabling local authorities both improve the use of public money and raise their citizens’ satisfaction rates.The 3 partners, will peer-review other similar initiatives, in order to come up with a backbone of a “design service” offered to the local ecosystem by innovation agencies, that will enable cities, SMEs and citizens collaborate for the common good. The consortium members will set up a procedure where all the beforementioned parts will collaborate to “frame the challenge”, “ideate possible solutions”, “prototype” the best of them, “test” them in real life and adopt the ultimate one that satisfies the most, all stakeholders involved. In the end, the partners will set up a new service, which will be piloted in Greece by KEPA. The service will ensure that all stakeholders will be included and KEPA will facilitate the procedure of solving a social challenge by making maximum use of local SMEs expertise. The partners, based on the peer-learning activities and the Pilot Action, will develop a “Design Options Paper” –a guidebook on how other innovation support agencies can also cope with social problems and SMEs activation.


**Keywords:** innovation , SMEs , ROI , capacity , social_challenges
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exploiting carbohydrate/N-heterocyclic carbene hybrid complexes as innovative multifunctional oxidation catalysts with tailoring of weak interactions allowing for development of enzyme mimics' (GLYCONHC).

assistant: **Innovation**

The key objective of this project is the development of innovative hybrid complexes for oxidative catalysis of pharmaceutically relevant functional groups (e.g. alcohols, amines, olefins), by combining the beneficial properties of triazolylidine N-heterocyclic carbenes and carbohydrates for synergistic catalysis and molecular recognition, ensuring site-specific bind making and breaking processes and tailored delivery. A range of novel carbohydrate-functionalised NHC complexes (e.g. with Ru(II) and Ir(III)) will be synthesised for these purposes and relationships between carbohydrate structure/geometry and catalytic activity probed, complementing experimental approaches with computational insight.NHCs are synthetically versatile and have been demonstrated to have beneficial properties as ligands for catalysis. Triazolylidine NHCs are accessible via modular 'click' chemistry and readiliy functionalised, but not as widely explored as other classes of related compounds. Functionalising carbenes with carbohydrates is practically unknown in the literature despite many advantages such derivatives would possess, including well-defined geometry, rich hydrogen bonding and proton-shuffling interactions, recognition by biological receptors (providing the opportunity for developing NHC-based metalloenzyme mimics through interdisciplinary collaboration) and also chirality (allowing for enantioselectivity). The candidate has synthetic experience matching the project and will benefit from the specific training activities within the host group (who have vast NHC experience), mobility and change of topic to achieve research maturity.Deliverables will include: 1) New catalysts for high-turnover oxidation of pharmaceutically relevant substrates 2) Innovative metalloenzyme mimics based on N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'National corporate cultures and international competitiveness strategies - the challenge of globalisation for european smes.'.

assistant: **Innovation**

Increasing economic Europeanisation and globalisation is putting the pressure of adjusting to rapidly changing conditions not only on large corporate groups but also on small and middle-sized enterprises (SMEs). Comparative international studies on Europeanisation and globalisation strategies in SMEs however do not yet exist. This omission is all the more serious when one considers that SMEs continue to be responsible for most of the production and employment in most industrialised countries in Europe. The proposed RTD-Project is intended to help close this gap by pursuing the following questions: Which strategies are being used by management in SMEs in Germany, France, Italy, Austria and the Netherlands to meet the challenges of the current push for economic Europeanisation and globalisation?And what effects do these strategies have on the development of regional economic structures and on the corporate cultures and working climates in individual companies?