RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A high speed logarithmic arithmetic unit' in the context of a Fourth Framework call.

assistant: **Objectives**

A research programme is proposed which has the following aims in its 1st phase.- To refine the algorithms for LNS arithmetic, to offer better average accuracy than FP.- To design an ALU cell for its economical implementation, and to show that this cell will perform at higher average speed than FP.- To verify the superiority of the LNS design by simulated comparison with FP in a variety of general mathematical and DSP applications.This work during the 1st phase will be aimed at finalising the arithmetic algorithms and proving their superiority over floating-point. Theoretical refinements will be made to the algorithms in order to achieve the targets for speed and accuracy. A software simulation will be made available with which the accuracy of the system can be evaluated against that of floating-point, and proven over a range of larger-scale applications. A software library of DSP applications will be built. A detailed ALU cell design will be done, and from this it will be shown that the device will meet the target speed, and that it can economically be fabricated.Once the feasibility of the approach has been demonstrated and the objectives of the 1st phase have been achieved the project will enter into a second phase with the following aims:- To fabricate the design, to produce the world's first LNS-based ALU with significant advantage over FP; and to test and verify this in real-time practical applications.- To incorporate the ALU in commercial custom DSP devices, to allow independent verification.- To develop a complete LNS-based microprocessor.There is a world-wide demand for accurate, high-performance arithmetic devices. These find application in two primary areas : general-purpose computing (e.g. Intel Pentium) and digital signal processing (e.g. Texas Instruments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Role of the cytoplasmic tail of hiv and siv in envelope expression and virus release' (1994-1998).

assistant: **Innovation**

Research objectives and content The envelope glycoproteins of the human and simian immunodeficiency viruses (HIV and SIV) are responsible for cell infection by mediating virus binding and entry. It is known that they are also important for late events in the replicative cycle in particular the assembly, budding and release of newly synthesised virions. It has been suggested that the cytoplasmic tail of the transmembrane component of the envelope glycoprotein can modulate the cellular location, cell surface expression and incorporation of envelope into viral particles. I propose to characterise the features of the protein that mediate these effects and investigate the interactions between the envelope glycoprotein cytoplasmic domain and other viral and cellular proteins. This will be done by analysing the intracellular transport of newly synthesised envelope glycoproteins and locating the sites of viral budding. I will perform morphological and biochemical analyses on the envelope glycoproteins (and mutants of these proteins) expressed in T cells and macrophages alone, or together with other viral structural proteins. For these studies, I will benefit from the expertise of the host institution in the cell biological analysis of virus-cell interactions, the use of novel expression techniques (e.g. Semliki Forest virus) and the use of green fluorescent protein as a means of protein tagging. Training content (objective, benefit and expected impact) I anticipate this project will lead to a clearer understanding of the assembly of HIV and SIV, and a better understanding membrane protein sorting mechanisms in general. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The dynamics of social change in europe' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The research had five objectives:1. To undertake studies of the processes of change in the domains of family structure, employment, household income and living standards.2. To establish the mutual influences of each of these domains on the others.3. To draw conclusions about the roles of social policy, and the prospects for reform.4. To exploit the research opportunities provided by the European Community Household Panel survey (ECHP), applying the most advanced analytical techniques.5. To encourage wider use of the data among European social scientists, both by example, and by providing direct support services.The research will be based on the quantitative analysis of longitudinal data. The ECHP has been following the same sample of people in most EU countries since 1994; by the end of the research programme it will provide a continuous sequence of six or seven years.The research team is composed of specialists in the analysis of household panel data, and its members are already familiar with the ECHP.The programme is specified in terms of research packages under three headings:(i) labour market;(ii) family and employment;(iii) income and quality of life.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A Pilot Plant for the Production of Polymer based Nanopharmaceuticals in Compliance with GMP'.

assistant: **Concept**

The aim of NanoPilot will be to set-up a flexible and adaptable pilot plant operating under GMP for the production of small batches of polymer-based nanopharmaceuticals, which exhibit significant potential in the field of drug-delivery particularly for the design of second-generation nanopharmaceuticals.Three different processes will be established for the production of three different nanopharmaceuticals selected on the basis of their TRL and positive commercial evaluation: a) topical treatment of ocular pain associated with dry eye syndrome containing short interfering RNA and lactic acid, b) A resuspendable HIV nanovaccine for intranasal vaccination containing 12 peptides in its formulation. c) Hyaluronan based hollow spheres intended for intravesical instillation, for the treatment of interstitial cystitis/painful bladder syndrome.State of the art production processes including micro reactors and highly advanced characterization techniques will ensure the quality of the nanodrugs. Existing laboratories suitable for large-scale production of biologics in compliance with GMP, and owned by the coordinator, will be adapted and certified within this project to enable the operability of the pilot plant.NanoPilot consists of nine complementary partners composed by 1 Industry and 2 academia developers of the nanosystems to scale-up. A research Institute expert in nanoparticle characterizacion and already operating in compliance with Good laboratory practices. An SME and an Industry that will develop ad-hoc continuous flow reactors for the optimization of two of the three processes. A consultancy (SME) expert in Quality system implementation and laboratory information management systems. A second consultancy (SME) in charge of the business plan, that will also help the coord
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of new methodology for characterizing the active phase and its interactions with the support in novel sulfide hydrotreating catalysts' (1994-1998).

assistant: **Concept**

NOVEL CATALYSTS CONSISTING OF NiMo OR CoMo SULFIDES SUPPORTED ON OXIDES SUCH AS TiO2, TiO2-A12O3 OR ZrO2 HAVE SHOWN TO EXHIBIT SUPERIOR HYDROTREATING ACTIVITIES THAN CONVENTIONAL ALUMINA SUPPORTED NiMo OR CoMo CATALYSTS. HOWEVER, THE RELATION OF THE CATALYTIC PROPERTIES OF THESE SYSTEMS WITH THEIR PHYSICOCHEMICAL PROPERTIES IS NOT YET FULLY UNDERSTOOD. THIS RELATION DEPENDS ON THE NATURE OF THE ACTIVE PHASE AND ITS INTERACTIONS WITH THE DIFFERENT TYPES OF OXIDE SUPPORT. THE FIRST OBJECTIVE OF THIS PROJECT WILL BE TO CHARACTERIZE THE NATURE OF THE ACTIVE PHASE AND ITS INTERACTIONS WITH THE SUPPORT OF THESE CATALYTIC SYSTEMS. THE CHARACTERISATION OF THE CATALYSTS WILL BE EF'F'E;CTED BY USING RAMAN SPECTROSCOPY (NTU, ATHENS) ASSISTED BY IR, ESR, HREM, AND CATALYTIC MEASUREMENTS (IRC, VILLEURBANNE). THE SECOND OBJECTIVE OF THIS PROJECT CONCERNS AN IR/RAMAN SPECTROSCOPIC STUDY OF THE PROPERTIES OF RUTHENIUM SULFIDES DISPERSED IN Y-ZEOLITES WHICH HAVE ALSO SHOWN VERY PROMISING HYDROTREATING ACTIVITIES.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Portable automated test for fast detection and surveillance of influenza' (PORTFASTFLU) targeting Seventh Framework.

assistant: **Abstract**

The PORTFASTFLU’s objective is to develop and validate a rapid diagnostic test for influenza that will be used as point-of-care systems in developed and developing countries. Experts and international bodies agree that the rapid detection of influenza is vital in combating this major threat to human health. Nucleic acid analysis is the most appropriate assay scheme for both early detection and late surveillance of influenza, and is routinely used by WHO and OIE virology reference laboratories. PORTFASTFLU's consortium aims at developing and validating a Point of Care (POC) instrument which will integrate sample preparation, nucleic acid amplification, microarray hybridization and fluorescent readout in a single system. Reaching this challenging objective is possible through the combined expertise of the partners and comprises access to several selected enabling technologies: microfluidics, on-chip sample preparation, advanced microarray techniques and reading systems with ultimate sensitivity and selectivity, access to reference and field virus samples. This Bio-Micro knowledge converges in one single instrument, allowing rapid detection (less than an hour) and simultaneous identification of influenza A and B viruses (typing and sub-typing) at widespread POC with only basic skills. Furthermore, the project also aims at realizing this goal in a format that requires little supervision and is integrated in a portable compact monolithic system for deployment in the field. The consortium of 9 partners from 5 member states brings together the various expertises needed to reach these objectives, which match exactly those of the call Health 2.3.3-4: Innovative point-of-care diagnostic tests for influenza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nano-Scale Protective Oxide Films for Semiconductor Applications & Beyond' (NANO-PROX), addressing dissemination and exploitation.

assistant: **Impact**

Conventional demands for development in semiconductor industry are changing as the Moore’s Law approaching to its limits. Continuous decrease in the size of the transistors is coming close to atomic levels creating a fundamental barrier for further process developments as the semiconductor manufacturing is established today . Growth of thin films and inherent stress development within the film and film/substrate interface are critical for multiple phases of microelectronics manufacturing. Particularly, protective oxides of metal films are foreseen to have wide applications as (i) an interfacial layer to improve the adhesion and/or limit penetration of reactive chemicals of a deposited film (ii) as a subtractive layer to achieve selective material removal and (iii) as a nanofilm with inherent self growth limiting capability that could be used for nanoscale electronics manufacturing. Fundamental understanding of the proposed research is expected to be utilized in many other fields such as in biological systems to improve corrosion on bio-implants and, applications in which the interface and thin film properties affect permeation of reactive chemicals such as fusion reactor design or as ferroelectric capacitors where hydrogen permeation detoriates device functionality. Dr. Basim, the Principal Investigator of this study has been actively involved in semiconductor research and development for more than ten years at major semiconductor companies in US. Her expertise is on integration of newly adapted semiconductor processes, defect reduction during manufacturing and chemical and mechanical interactions on thin films. She will initiate her research at Ozyegin University, Mechanical Engineering Department with the support of the IRG funds if awarded. Dr. Basim’s new appointmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Methylation Profiling Diagnostic for Early Diagnosis of Alzheimer’s disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Each year an estimated 40M people suffer from Alzheimer’s disease (AD) globally, and a new case is diagnosed every 4 seconds, leading to a substantial socioeconomic burden of over €800B annually. Despite this large need, currently there is no cure available for AD. Moreover, the clinical trial failure rate for novel AD therapies being tested is over 99%. Every failed trial leads to large financial losses for the trial sponsor, and as a result there is an urgent need to reimagine AD clinical trial design. Recently, there has been a paradigm shift in the design of AD clinical trials, with most new trials now focusing on enrollment of Prodromal AD (P-AD) patients. However, patient recruitment in the P-AD stage is challenging as current methodologies (PET, MRI) lead to a large number of false positive and negative cases. As a result, optimal stratification of P-AD patients during clinical trial recruitment, remains an unmet market need. To meet this market need, ADmit Therapeutics, an innovative diagnostics SME, aims to deliver MAP-AD: an automated epigenetic analysis platform for accurate prediction of progression status of P-AD patients. The MAP-AD platform relies on novel machine learning algorithms that can identify specific methylation patterns in mitochondrial DNA (mtDNA) isolated from the blood samples of P-AD patients. This allows for a rapid and accurate selection of patients to be enrolled into a clinical trial independent of Aβ status, for the first time. During this EIC Accelerator project, we will finalize the development of our predictive algorithms together with a dedicated software interface, and perform clinical validation in collaboration with our hospital partners to deliver a finalized platform that is ready for commercial launch. We have a strong networ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multiple stressors - the combined effect of pesticides, cyanotoxins and infochemicals on zooplankton' to be submitted under Sixth Framework.

assistant: **Abstract**

The goal of the project is to describe the COMBINED INFLUENCES of MULTIPLE STRESS factors on zooplankton. The reaction of organisms to simultaneous influences of several stress factors cannot be predicted by simple adding up effects. Often effects are larger than expected (i.e. synergistic effects). Zooplankton plays important role in aquatic food webs and it is crucial to know how anthropogenic chemicals (such as pesticides) and cyanotoxins (as a result of eutrophication) interact and affect population dynamics, population genetical structure, and community structure. This knowledge is of high importance from economical (e.g. losses in aquaculture) and environmental (e.g. human and animal health, ecosystem stability) point of view. Moreover, this project al so aims at finding 'neutralizers' to reduce the negative impact of stressors.The combined influence of pesticide, cyanotoxin, predator infochemicals and polyunsaturated fatty acids will be tested on clones (genotypes) of Daphnia species in life history an d community experiments. Experiments will be conducted using advanced techniques such as highly controlled flow through systems, cosms, genetic analyses, high performance liquid chromatography, solid phase extraction and emulsion techniques to add polyunsa turated fatty acids to algal diets. Analysis of effects of combined natural and anthropogenic chemicals on species and community is critical for full understanding of risks to environment and humans. The concerns and needs are stated in the Water Framework Directive, European Biodiversity Strategy and European Environment and Health Strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cellular and Molecular Mechanisms of Mechano-sensitive Signalling in Vascular Endothelial Cells' in the context of a Fourth Framework call.

assistant: **Objectives**

- To determine properties, structure, modulation and the functional role of mechanically-gated chloride channels in vascular endothelium - To determine properties and modulation of mechano-sensitive Ca2+ entry in endothelial cells.- To determine changes in the expression and presentation of P and E selectins and changes in leukocytes adhesion in endothelium after mechanical stimulationVascular endothelial cells (EC) are constantly exposed to mechanical shear and strain forces. These forces induce a variety of EC responses, such as changes in the intracellular Ca2+ concentration, pH, phosphoinositol turnover, tyrosine phosphorylation, NO release and secretion of a variety of vasoactive compounds finally leading to changes in gene expression and cytoskeletal remodelling. The cellular and molecular mechanisms responsible for the signal transduction between mechanical stimuli and EC responses are not known. This research proposal therefore is focused on mechano-sensitive signalling, i.e. the elucidation of mechanisms by which mechanical forces can be transduced into cell responses. Three major mechanisms will be investigated: 1. Properties of mechano-sensitive Cl channels (Icl, mech) including their molecular biological characterisation of Icl mech their modulation via the cytoskeleton, annexins, via tyrosine phosphorylation, their functional role as transporters of metabolites for NO synthesis, as modulators for EC proliferation, and as modulator of Cl-dependent protein kinases. 2. Properties of the mechanically activated Ca2+ release and Ca2+ entry which will comprise an electrophysiological characterisation of the mechanically induced Ca2+ entry including modulation by depletion of intracellular Ca2+ store and a characterisation of the Ca2+ influx in EC through stretch-a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Atmospheric deposition and impact of pollutants, key elements and nutrients on the open mediterranean sea (ADIOS)' (ADIOS).

assistant: **Innovation**

ADIOS is a focussed pan-European study of the atmospheric deposition and impact of pollutants, key elements and nutrients on the Mediterranean open sea. The extent to which atmosphere represents an important pathway for various pollutants and natural substances from Europe and North Africa towards this ecologically sensitive marine environment, and subsequently affects its biogeochemistry remains largely unknown. The magnitude and quality of atmospheric deposition will be assessed by an atmospheric sampling network encompassing the whole basin, as well as by the extensive use of Sea WIFS data and dust transport-deposition modelling. Biogeochemical processes, levels and ecotoxicological effects induced by natural and anthropogenic aerosols will be examined, from surface down to the deep sediments, in two central sites of the Eastern and Western basins, using oceanographic surveys, moored instrumentation and 3D ecohydro dynamical modelling.The actual outcome of the project can be summarised in the following way, with respect to the initial objectives:1. Remote sensing and modelling of atmospheric inputs: better characterisation of natural and anthropogenic inputs at the scale of the entire Mediterranean basin; improved dust load maps and atmospheric transfer-deposition models; improved integration between the two complementary approaches;2. Sampling and chemical characterisation of atmospheric inputs: better quantification and chemical characterisation of the levels and variability of atmospheric inputs of pollutants, key elements and nutrients over the entire basin; improved ground truth/remotely-sensed data relations;3. Biogeochemical response of the open Mediterranean environment to atmospheric inputs: better understanding of effects nutrients on the biogeochemical pro