RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Basic Research for Innovative Fuels Design for GEN IV systems'.

assistant: **Objectives**

Up to now fuel development and qualification has been a long and expensive process essentially based on an empirical approach. European experts currently have an adequate knowledge of conventional fuel manufacturing and its behaviour under operating conditions encountered during 50 years of industrial application and R&D activities. For innovative fuel systems, however, the empirical approach has reached its limit and cannot be easily extrapolated to new materials, new environments, or new operating conditions because the basic underlying mechanisms governing manufacturing, behaviour and performance remain largely poorly understood. One of the challenges for the next years is to supplement the empirical approach by a physically based description of ceramic fuel and cladding materials.    To do so, the F-BRIDGE project, which stands for Basic Research for Innovative Fuels Design for GEN IV systems, intends to develop a new approach to fuel development by building a bridge (integration and transfer) between basic research activities and technological applications for the Generation IV fuel-cladding systems. Besides a general approach on ceramic materials, the project will focus on the improvement of a promising composite ceramics concept, the sphere-pac fuel, which exhibit significant advantages for Generation IV.  F-BRIDGE aims at: - obtaining data, mechanisms and models from basic research for an improved description of fuel and ceramic cladding materials under irradiation, in a multi-scale approach coupling separate effect experiments and modelling,  - ensuring the transfer between basic research and technological issues related to Generation IV systems and illustrating the integration effort through a multi-scale modelling exercise on UO2, - assessing the technologica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PRECEDE: PancREatic Cancer Early DEtection' (PRECEDE).

assistant: **Concept**

PRECEDE (PancREatic Cancer Early DEtection): Pancreatic cancer is a devastating disease. Five year survival is only 3% and this figure has not changed for 40 years. A recent EU study has shown that this is the only cancer who’s incidence and mortality are set to increase. By the time patients present with symptoms, the disease is usually advanced and untreatable. The most effective way to improve survival would be to diagnose the disease earlier when therapy is more likely to be successful.CA19.9 is an approved biomarker for aiding diagnosis of pancreatic cancer in symptomatic individuals. Its sensitivity and specificity are not high enough for screening healthy high risk individuals due to the high number of false positives caused by the natural variation in levels within a population. Abcodia has developed an algorithm that learns an individual’s healthy baseline of CA19.9 and spots any inflection point as pancreatic cancer develops. This personalisation of the CA19.9 test increases sensitivity by identifying low but increasing values, improves specificity by discounting high but flat profiles and detects the disease earlier through regular testing and spotting inflection points. Abcodia has developed the algorithm based on longitudinal pre-diagnosis levels of CA19.9 levels from 64 pancreatic cancer cases and 161 healthy controls from the UK Collaborative Trial in Ovarian Cancer Screening, which for over 10 years monitored the health of 202,000 initially free from cancer women. The algorithm improves the performance of the marker CA19.9 and detects the disease earlier than standard diagnostic practice. The algorithm now requires clinical validation in a population based clinical trial across Europe to allow full commercialisation.This phase 1 project will build a robu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Connecting ICT and Art communities: new research avenues, challenges, and expected impact' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The FET-ART project stems from the ICT & ART Connect" event that took place in Brussels in April 2012 under the aegis of the FET Unit, with an important support and contribution of several FET-ART partners.<br/>This event clearly confirmed that a great potential exists in fostering dialogue between ICT and Art practitioners, and this is the right time to efficiently support such dialogue in order to contribute to the emergence of novel FET research topics and the identification of new emerging research areas for H2020 in the ICT domain and beyond.<br/>Within this context, a FET-ART balanced partnership of committed organisations has been formed, offering renowned expertise in the ICT and Art domains, important connections with ICT and Art practitioners in Europe and worldwide, many references at the ICT and Art interface, and longstanding experience of planned activities.<br/>The FET-ART consortium will, over the 12-month project period, connect the European ICT and Art communities, and foster productive dialogue and collaborative work between them, in order to identify new research avenues, associated challenges, and the potential impact of ICT and Art collaboration on science, technology, art, education and society in general.<br/>FET-ART will more precisely:\tOrganise "consultation events and matchmaking events" in at least five European locations,\tSupport at least 15 "pilot projects" of collaborative work between ICT and Art practitioners in residencies, seen as "proofs of concept" for some promising research topics or directions, particularly "co-creation" and "citizen engagement in ICT",\tOrganise a final open event in Brussels, part of an ambitious set of project outreach activities: web platform, community building, contribution to events, including to ICT 2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of the babar detector at the pep-ii-b-factory for the experimental study of cp violation in b meson decays' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content Since 1964, the CP symmetry has been known to be violated in neutral K meson decays. This very small effect, which could be linked to the observed dominance of matter over antimatter in the Universe, can be accommodated in the Standard Model of electroweak and strong interactions with three fermion generations. Such a scheme predicts sizeable CP violating asymmetries in few rare decays of mesons containing b quarks. Two B meson factories and their associated experiments are under construction in order to measure the time dependence of the CP asymmetry. One of them, the BABAR collaboration, involves many European laboratories and Universities. The project will be developed in this environment. The tagging of the few and rare Br decay channels sensitive to CP violation requires a novel type of ring image Cherenkov detector, the DIRC (Detector of Internally Refiected Cherenkov light). The DIRC construction has been shared between French and American institutes (SLAC and Berkeley). The LPNHE has responsibilities on the front-end electronics, the calibration system and online (monitoring) and offline (pattern recognition) reconstruction programs. More global tasks taken up by the group are overall particle identification (using all subdetectors) and flavour tagging.Technical and physics activities will span the whole term of the grant. Due to the time schedule of the experiment, the emphasis will be put on the techical part at the beginning and on physics later on. The main technical points of the research project are the following: a) take part in the installation of the detector, in particular the DIRC; b) participate in the DIRC and. BABAR check out with cosmic rays and calibration; and c) become involved in online/offline object oriented C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Real-time analysis of ribosomal frameshifting and its impact on immunity and disease'.

assistant: **Innovation**

The coding region of many genes contains sequence elements that constitute roadblocks during mRNA translation. These roadblocks present problems, but also opportunities for the cell to increase the coding capacity of the genome by so-called programmed ribosome frameshifting (PRF). PRF is a universal gene expression strategy that brings plasticity to the proteome. It is widely studied in viruses and bacteria, yet poorly understood in humans.My own mechanistic discoveries have highlighted that, regardless of various stimulatory structures and slippery nucleotides involved, PRF in bacterial and viral mRNAs follows one of the two general pathways depending on substrate. In contrast, many questions remain regarding the occurrences of PRF in humans and its regulation by recently discovered trans-acting viral and cellular factors.In T-FRAME, I will investigate the mechanism of PRF and its role in disease using HIV infection of human-T lymphocytes as an in vivo paradigm. To study molecular details of how trans-factors modulate PRF, I will leverage cutting-edge ensemble and single-molecule techniques to monitor the ribosome as it moves along the mRNA codon per codon. In addition, I will assess mRNA interactions with PRF factors during this process. Using a PRF-RNA-interactome capture assay that we have recently developed, I will search for new trans- factors in human cells. Finally, I will study the translation of T cells and HIV-1 on a global level during infection to understand the full scope and dynamic nature of PRF in this model system.To summarize, T-FRAME will advance our understanding of how RNA structure and trans-factors shape translation regimes in higher eukaryotes and how deviations from the standard decoding path impact infection and innate immunity. I envision har
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Decision-Driven Phase Transitions in Biological Collectives via Interpretable Multi-Agent IRL with Closed-Loop VR and Robotic Platform Validation'.

assistant: **Innovation**

CRIT-IRL will uncover the individual decision rules that drive phase transitions in biological collectives and will validate these mechanisms causally using closed-loop virtual reality (VR) and bio-hybrid robotics. The project addresses a key gap: existing models reproduce global patterns but rarely capture interpretable, context-dependent decisions—or show how such decisions generate critical transitions at the group level.Objective 1. From trajectories to decision rules: infer interpretable, multi-objective policies from high-resolution multi-animal data via multi-agent inverse reinforcement learning (IRL) with graph-based interaction modelling; deliver a validated model, curated datasets and open code.Objective 2. From decision rules to criticality: construct phase diagrams linking decision parameters to collective regimes; derive early-warning diagnostics (variance, recovery time, influential-agent scores) and identify critical individuals/time windows precipitating transitions.Objective 3. Closed-loop causal validation: embed the learned policy in immersive VR with live fish and deploy it on aquatic robots to steer groups across phase boundaries, benchmarking against rule-based baselines and ablations.Methodological innovations. Interpretable MA-IRL with constrained reward bases and heterogeneity; multi-scale validation (micro kinematics to macro order parameters); physics-informed mechanism mapping; embodied, counterfactual tests in VR/robotics. Open science: preregistered analyses, FAIR data, and reusable protocols/software.CRIT-IRL yields mechanistic insight into decision-driven criticality, principled controllers for bio-hybrid swarms, and transferable diagnostics for other complex systems (e.g., ecological monitoring, distributed AI). The fellowship provides i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Epigenetic and transcriptional basis of memory engram plasticity' to be submitted under Horizon Europe.

assistant: **Abstract**

Neuroplasticity underlies learning and memory formation, which allows for accumulation of knowledge. There is an emerging view that a sparse ensemble of neurons, termed as engram cells, represent memory substrate and explain how memory is formed and retrieved. Extensive studies have been carried out to reveal molecular mechanisms regulating structural and synaptic plasticity of memory engram cells. However, there are still fundamental questions remaining to be solved regarding epigenetic and transcriptional basis of recent and remote memory formation, and heterogeneous identity specification of engram cells.     To address these issues, I will carry out state-of-the-art genomics/epigenomics analysis of engram cells that are permanently labelled during recent and remote fear memory consolidation. Firstly I will reveal epigenetic and transcriptional mechanisms regulating active-silent state shifts of engram cells during systems memory consolidation in the hippocampus and neocortical regions. Next I will address heterogeneity of engram cells and reveal how a subset of engram cells may become functionally relevant during memory consolidation and retrieval. To particularly address the latter issue, on top of existing sequencing technologies, I will also apply a novel “time machine”-like retrospective whole-genome history tracing approach to obtain molecular profiles of a given timepoint in the past, and overcome the critical limitation of current snapshot-type technologies. To validate relevance of my findings, I will also carry out functional analysis including gene knocking-down and optogenetics approaches.      My interdisciplinary research program will shed new light on how environmental cues, including cell-to-cell interaction mediated by neuronal activity and signallin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Evaluation of the inactivation / removal effect of the gelatin manufacturing process on tse infectivity' to be submitted under Fifth Framework.

assistant: **Abstract**

For the manufacture of bone gelatine a downscaled Pilot model has been developed and tested to reflect as close as possible the industrial processes and to represent the typical manufacturing conditions. Spiking crushed fresh bone with 30 I V infected mouse brain (BSE agent) and 263 K infected hamster brain (scrape agent) and processing these materials through the downscaled model to produce gelatin. Using the processed material from the whole process to determine the residual infectivity of gelatine and declaim-phosphate by bioassay. Evaluating separately the inactivation capacity on individual process steps of the finishing unit operations by spiking the industrial starting material and processing this material through these steps and measuring the remaining infectivity. In total 17 samples are prepared and submitted to bioassay. All samples are additionally tested by immunoblotting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Elaboration of an evaporative cooling technique with shear-driven liquid films' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main goal of the proposal is to elaborate a new technology for active cooling of high heat flux equipment, using thin, intensively evaporating liquid films driven by the action of a forced gas flow in a narrow channel. The main practical motivation of the project is to develop a design capability and design tools that would enable effective cooling of powerful microelectronics for terrestrial and space applications. This capability must be based upon the development of a fundamental understanding of the parameters enabling high heat transfer rates in such thin film systems. It is proposed to develop such fundamental understanding through conducting systematical experimental studies, including studies in microgravity during aircraft parabolic flights. The experiments will be performed on test sections with flat and microstructured local heaters, which will be brought to the host institution (ULB) by the applicant. ULB possesses all necessary experimental facilities to organize and study shear-driven liquid film flows. In the experiments several state-of-the-art techniques will be used (Schlieren methods, Infrared thermography, Fiber optical thickness probe, High speed CCD camera). The proposed research is supposed to make significant advances in basic knowledge of liquid film heat transfer and rupture, and eventually may lead to a new practical cooling technology with broad area of applications in the marketplace. The proposed research, as well as applicant’s scientific experience, is relevant to the research interest and activities of MRC group of ULB. MRC-ULB has close collaboration with Euro Heat Pipes S.A., aiming at elaboration and creation of an advanced film cooling system for powerful microelectronics. Part of the proposed research is in the framework of ESA-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Gratings in air-core photonic bandgap fibres for applications within communications, lasers and sensors""'.

assistant: **Concept**

This project aims to inscribe novel gratings, including fibre Bragg gratings and long period fibre gratings, within air-core photonic bandgap fibres (PBFs) and to systematically investigate their applications within optical communications, fibre lasers and sensors. If successful the project will open the door to a host of new grating-based devices. This project will address the fundamental problem of how to induce a periodic index modulation that can be experienced by an optical mode propagating within an air core – a problem that has seriously obstructed the development of gratings and grating-based devices in air-core PBFs for the past decade. I propose to investigate several promising techniques for perturbing/deforming periodically the air holes along the fibre axis with either a CO2 laser, or a femtosecond laser. In addition, I shall develop a special air-core PBF with a photosensitive core wall that should allow grating inscription using the common UV laser exposure technique. Air-core PBF gratings are quite distinct from any former gratings in index-guiding fibres and have unique optical properties due to the air core. Moreover, the unique microstructure in air-core PBFs will allow thermo- or electro-optic polymers and other advanced materials to be incorporated into the air holes/core, offering a new platform for developing innovative communication and sensing devices. Active and passive devices such as in-fibre polarisers, tunable filters, and pulse compressors could be used to develop next generation all-optical fibre communication networks. The smart sensing elements to be developed, especially gas, biochemical, and biophotonic sensors, could be used to monitor environmental pollution, gas concentration, water quality, and the health of railways, bridges, bui