RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular Mechanisms of Alternative Pre-Mrna Splicing: Function of Spf45 the Its Role in B-Thalassemia' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Alternative pre-mRNA splicing is a mechanism of regulation of gene expression that affects at least 60% of human genes. Inaddition, at least 15% of genetic defects are associated with aberrant pre-mRNA splicing, an incidence that reaches 40% formulations that inactive genes encoding for example the tumour suppressor BRCA1 or the gene responsible for neurofibromatosis. The molecular mechanisms controlling this process during cell differentiation and development, andtheir alterations in pthological situations are not well understood. Recent work in the host lab has identified a novel mechanism of splicing regulation whereby the regulatory protein Sex-lethal (SXL) inhibits splicing of a specific intone within its own pre-mRNA at the very last step of the splicing reaction (axon legation) (Lillian et al, 2002). This is in contrast with other mechanisms described previously, which target early events in splice site (sis) recognition. The work also revealed a critical role for the splicing factor SPF45 in selecting particular 3\'sis and in allowing regulation by SXL. SPF45 is the first known splicing factor that recognizes directly the 3\' sag and at the same time activates it for catalysis. Interestingly, SPF45 was also found to be involved in the activation of cryptic 3\' sis located upstream from the natural 3\'sis in the ÿ-globing gene. Activation of the cryptic site, which breaks the open reading frame and therefore prevents the mRNA from encoding functional ÿ-globing protein, is caused by a G to A mutation responsible for one form of ÿ-thalassemia (ÿ110). We propose a structural/functional analysis of SPF45 to understand its activities as(a) second step splicing factor,(b) selector of 3\' sis AG for catalysis,(c) mediator of SXL auto regulation and(d) activator of the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The relevance of judicial (dis-)trust for the legal integration of the European Union' (CURIAFIDES) targeting Horizon Europe.

assistant: **Abstract**

The functioning of the European Union (EU) legal system is ensured through an intricate interdependent and non-hierarchical judicialsystem, where judges at the Court of Justice of the EU (CJEU) and national courts must rely on the willing cooperation with each otherto enforce decisions on EU law matters. Scholars have pointed to the relevance of legal, historical, sociological and political factors inexplaining why courts cooperate within the EU judicial system. However, recent scholarly and policy debates underline the relevanceof trust-enhancing solutions in addressing some of the current challenges facing the EU legal system: specifically that of judicialdefiance of national courts to the authority of the CJEU. These concerns have been aggravated in the context of democratic and ruleof law backsliding in Hungary and Poland, which have raised serious doubts about the correct application of EU law within a networkof thousands of national courts. Despite this incipient interest, we still lack adequate theorising about the truly sociological andrelational nature of this phenomenon, which is crucial for the development of a more fine-grained account of inter-judicial relationsand for answering: what is trust between judges? Which factors make judges trust other judges? What are the implications of judicialtrust for cooperation in multi-level systems? The CURIAFIDES project is an interdisciplinary and ground-breaking research project,aiming at investigating the relevance of trust between judges for the cooperation and, subsequently, the legal integration of the EU.The project will articulate a novel socio-legal theory of judicial trust within the EU, which will be based on strong empirical evidencecollected from experiments, surveys, and interviews with CJEU and national j
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Assessing childRen manIpulation and Exploration skiLls' (ARIEL).

assistant: **Concept**

Investigating object manipulation is crucial for the comprehension of child development and the early assessment of sensorimotor impairments. However, no current available methods allow a complete and widespread characterization of the process: (i) they do not measure all the core components of manipulation, such as the object motion and the forces applied; (ii) they are too expensive due to the cost of the devices or the need of expert annotators; (iii) they are not designed for children. ARIEL (Assessing childRen manIpulation and Exploration skiLls) aims to develop myCube (multisensory Cube) a tool enabling quantitative assessment of object manipulation, designed to be engaging for children and accessible at low cost, both for neurotypical children and those with neurological and developmental disorders. MyCube is a lightweight sensorized cube measuring its orientation in space and the position and pressure of tactile contact points on its faces. It produces vibratory and auditory feedback and presents raised patterns on the surface, which can be haptically explored. The myCube design allows for easy customization of the stimulation, with a simple way of substituting the patterned silicon faces. Stemming from the promising results of the ERC wHiSPER project in the assessment of individual haptic exploration, ARIEL will: (i) develop the myCube device, software, and haptic assessment procedures; (ii) validate its effectiveness in a large cohort of school-aged healthy children and a group of children with cerebral palsy in collaboration with expert clinicians, and (iii) plan a feasible market implementation to maximize its impact. The resulting myCube kit, composed of two myCubes, the software for data analysis, and the haptic assessment testing procedure, will represent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dendritic Activity and Neuromodulators in Active Learning' (DANAL) under Horizon Europe.

assistant: **Objectives**

Neuroscience research tries to tease apart how brain circuits work together to give rise to behaviour, namely cognitive flexible processes, such as reinforcement learning (RL). RL requires neurons to be tuned to relevant inputs in order to maximize behavioural performance. Most of the excitatory synaptic inputs in pyramidal neurons are located in the thin dendrites where the majority of the spines are located. Thus, thin dendrites play a crucial role in synaptic integration and experience-dependent plasticity. They mediate local computations that endow single neurons with a variety of inputoutput transformations and change their information transfer. In agreement, individual dendrites have been proposed as the fundamental computational unit of neurons and the substrate for increasing the computational power of the brain. On the other hand, the neuromodulatory systems are known to be critical regulators of brain states and of adaptive responses relevant to RL. Different neuromodulators, acting through their receptors, can alter intrinsic properties of dendritic ion channels and receptors and synaptic efficacy, having a direct impact on dendritic computations. Thus, in order to understand how the brain allows to quickly improve behavioural performance during RL, it is critical that we 1) gain insight about the activity on thin dendrites, 2) to systematically understand the activity of different neuromodulatory inputs on those and 3) their impact on RL. This proposal aims at identifying how neurons change their properties during RL, by observing and manipulating the neurophysiology of behaving mice, using interdisciplinary approaches and state-of-the-art methods. The work will address several original questions: 1) what is the role of tuft dendritic activity to implement a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A coates spherical rotary valve combustion engine design to replace camshafts and poppet valves' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Work undertaken to date on a spherical rotary valve system for Internal Combustion Engines by the inventor Mr G Coates and by Nicholson McLaren Engines Ltd, has indicated that the concept does indeed offer a viable alternative to the traditional valve assemblies (involving poppet valves, springs, tappets etc). However, a number of significant problems have been identified. These need to be solved before fully engineered designs can be produced. Certain areas also require considerable development. More specifically, new materials need to be identified and/or developed for use in the production of bearings, seals and thermal barrier technology for the spherical valve design. When complete, the above research and development will be built into modern European 2.0 Litre engines to prove the successful operation of the mechanism and to demonstrate the distinct advantages of rotary valves over conventional poppet valves. The expected benefits are: * Lower emissions (with an aim to significantly improve on the requirements laid down in 1988). * Improved fuel economy. * Lower idling speeds, thereby using less fuel in urban situations and again producing fewer emissions. * Reduced manufacturing, assembly and maintenance costs. * Extended practical life of components and engine lubricants. * Substantially reduced power requirement from the crankshaft for driving of valve gear. * Opportunities for smaller overall engine design and resultant reduced vehicle drag factor . The prototype engine(s) will be tested for durability and emissions and endorsed with recogr.used certification. The approach will consist of the following stages: 1 Design & draughting of prototype components. 2 Dynanuc computer modelling for vibrations and thermal characteristics. 3 Development of prototype compo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Implementation of CRISPR/Cas9 technology in melon to edit fruit ripening and CMV resistant genes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Meeting with global food demand is one of the main priorities in the 2016-17 work programme of H2020. Virus diseases areamong the main causes of crop production losses, being Cucumber mosaic virus (CMV) the virus with broadest host range.On the other hand, post-harvest losses are estimated to account for 15-40% of fruit and vegetable production worldwide. Inthis scenario, several efforts are ongoing to identify genes underlying fruit quality and production such us those related withclimacteric ripening and CMV resistanceMelon (Cucumis melo L.) is one oft he most economically important group of vegetable crops after Solanaceae, and hasemerged as a crop model for important biological traits due to its phenotypic variability and the the availability of genetic andgenomic resources. Previous studies at the host group have identified and mapped genes involved in the regulation ofclimacteric fruit ripening and in a novel mechanism for CMV resistance in this species. MeloCRISP proposes to progress ourcurrent understanding on the genomic control of these important agronomic traits by functionally validating the identifiedcandidate genes. The CRISPR/Cas9 system will be implemented for the first time in this species and used for precise geneediting. In order to delay or impair fruit ripening in climacteric varieties, a gene knockout strategy will be approached. On theother hand, a precise nucleotide substitution in the resistance to CMV region (cmv1) will be performed to generate CMVresistant plantsThe expected outcome is the development of non-transgenic melon CMV resistant plants and varieties with improved fruitquality. This inter-sectorial and multidisciplinary project involves the engagement of a seed industry which will guarantee thetransfer of the results to the seed marke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable Tourism evidence-informed Policy' (SusTPol), addressing dissemination and exploitation.

assistant: **Impact**

SusTPol [Sustainable Tourism evidence-informed Policy] advances the understanding of using sustainability indicators to inform the governance of urban tourism. EU tourism policies recognise the importance of sustainability for competiveness, and the Commission contracted the University of Surrey to develop the European Tourism Indicator System. Yet the Commission still equates success to tourism’s contribution to growth and employment, and both Eurostat and European Cities Marketing measure tourist volume and expenditure, but not data on the impact that tourism has on residents or the environment. This IF contributes to implementing Communication “Europe, the world's No 1 tourist destination – a new political framework for tourism in Europe” and the Europe 2020 Strategy, by 1) experimenting with performance indicators of how tourism contributes to the EU policy on the Urban Environment, and 2) empowering policy makers so tourism contributes to implementing policies for sustainable urban planning and design. SusTPol analyses how tourist boards learn about sustainability indicators, adapt them to their needs, transform their governance systems and exploit the competitive benefits accrued. SusTPol collects baseline data (O1), supports tourist boards implement change in the form of policy-making experiments to support sustainable tourism development (O2) and conducts a Realist Evaluation (O3) of the contextual factors that allow for the use of indicators to support the selection and implementation of policy mechanisms that promote sustainable development. The tourist boards in the cities of Amsterdam (Netherlands), Barcelona (Spain), Ljubljana (Slovenia) and Vienna (Austria) agreed to participate as pilots, adapting their tourism planning, visitor management and marketing b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Microfluidic Alkaline eleCtrolysis for Green HYdrogen Via Electrochemical Reactions' in the context of a Horizon Europe call.

assistant: **Objectives**

MacGhyver has refocused its activities on a compact, scalable microfluidic alkaline electrolyzer for green hydrogen production with enhanced efficiency and the use of non-precious metal contents. The immediate objective is a 1 kW modular prototype employing high-ECSA electrodes and a 30-cell (10 × 15 cm) stack, enabling 0.45 kg/day hydrogen production at 1 A/cm² and 1.8 V with an energy demand of 56 kWh/kg H2. Reduced pumping requirements (<6 kWh/kg) target a overall production cost below €11/kg. By 2028, the project aims to scale to 10–20 kW systems with industrial partners, achieving 2 A/cm² at 1.8 V and costs below €5/kg, and ultimately extend to 100 kW+ modular systems for microgrids, decentralized industry, and green ammonia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Temporal Reasoning with Data for Verification' (DataVerif).

assistant: **Innovation**

The development of formal methods for the verification of computer systems is recognizedas a grand challenge by many research institutions. A successful approach for the verification ofsystems consists in modelling the system to be verified by a mathematical structure andin expressing behavioral properties in a logical formalism. The assumption that programs arefinite-state is usually too restrictive and model-checking techniques for infinite-state systemshave flourished these last 20 years. Our research program is motivated by the following assessment: most of model-checking techniques to verify infinite-state systems are mainly interested on the control and less on the data values stored by local or global program variables.In this project, the applicant shall develop verification techniques for systems heavily manipulating data, will design  relevant formal specification languages to express properties on data, develop algorithms using SMT solvers that are essential for computer-aided verification. This latter method is mastered by the members of the host institution, Analysis of Computer Systems Group at New York University CS Department.In view of expanding the applicant's skills and competencies, the research training objectives aremainly to  get a new expertise in an emerging technology mixing verification and automated deduction, to reach a position of professional maturity by initiating a new research team in the return host  dedicated to SMT techniques and  to provide transfer of knowledge by the supervision of early-stage researchers and by proposing new curriculum in master programmes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Set Top Box for Interactive Services on Demand' under Fourth Framework.

assistant: **Concept**

The objective of the SETBIS project has been the provision of tools in order to assess the user acceptance of interactive services on demand and broadband communication by application-driven pilot projects.The results of such acceptance tests are crucial to the success of the introduction of the interactive services on demand, the selection of the technology, giving the user access to the services, and for the decision of product development.To provide such acceptance test tools, a high-performance set top box for interactive services on demand and broadband communication has been specified and realised. It provides access to multiplexed, encoded digital audio/video signals and data, handles user input by the remote control unit and user output via text and graphics on the TV screen for navigation purposes. Security aspects are supported as well as fast response times.The result of this project represents a major advance in relation to the current state of the art in terminal development. Considering the broad consumer market for entertainment and education, major players in industry will be involved in this field, having already indicated their future engagement.The tools to evaluate the user acceptance for interactive services on demand and broadband communication are measurable objectives in terms of full availability of parameters required for acceptance tests and of the performance-to-cost ratio at low absolute costs.The set top box, as high-performance tool for user acceptance tests, puts the user and his/her interest at the focal point of telecommunication developments.The set top box has been integrated into the corresponding test environment, which is a comprehensive lab test system for interactive services on demand.The Set Top Box for interactive services on