RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Entangled Parliamentarisms: Constitutional Practices in Russia, Ukraine, China and Mongolia, 1905–2005' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The project addresses the entangled histories of deliberative decision making, political representation and constitutionalism on the territories of the former Russian and Qing Empires and focuses on the cases of Russia, Ukraine, China and Mongolia between 1905 and 2005. Employing the perspectives of the New Imperial History and Transcultural Studies, the project overcomes narrow state-centered approaches and takes advantage of multidisciplinary methodology crossing history and political science. The project traces parliamentary developments, the interactions among imperial and post-imperial intellectuals and their engagement in global discussions, shared imperial legacies, mutual borrowings and references, imperial and post-imperial political practices and translatability of concepts. It seeks to refute the stereotypes about inclinations towards democracy in particular national contexts by tracing relevant transnational practices and interactions and providing a nuanced political and intellectual history of parliamentarism. The team of five researchers (the PI, three PhD students and a post-doctoral researcher), will discuss and develop five individual and three cooperative studies. The PI will write a global history of parliaments and quasi-parliamentary institutions in Russia’s imperial formations (the State Duma of the Russian Empire, the congresses of soviets and the Federal Assembly of the Russian Federation). The three PhD students with relevant language skills will focus on parliamentary developments in the Ukrainian, Chinese (including Hong Kong and Taiwan) and Mongolian contexts. The post-doctoral researcher will explore the translatability of concepts between Russian, Chinese, Mongolian, Ukrainian and English. The three cooperative projects will focus on tradi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Xiphinema americanum-group virus-vector nematodes: development of a diagnostic protocol' (1994-1998).

assistant: **Innovation**

Background Currently, a scientific authoritative, harmonised European scheme is not available for detecting and diagnosing Xiphinema americanum-group nematode species which are recognised as being quarantine pests by both the European Union (Commission Directive 77/93/EEC, amended annex I/A1) and the European and Mediterranean Plant Protection Organisation (EPPO) (A2 Quarantine List No. 150). Several members of the X. americanum group are of phytosanitary significance as they are efficient vectors of four important plant viruses of quarantine significance: cherry rasp leaf nepovirus (EU annex I/A1; EPPO A1/127); peach rosette mosaic nepovirus (EU annex I/A1; under consideration by EPPO); tobacco ring spot nepovirus, potato calico strain (=potato black ringspot virus, EU annex I/A1; EPPO A1/128) and tomato ring spot nepovirus (EU annex I/A1; EPPO A2/102).The four viruses have been subject to pest risk analysis and are considered to present the risk of serious economic impact in Europe. The virus-vector potential of X. americanum- group species indigenous and widespread in the EU region has not been determined. However, the risks presented by the nematode species occurring outside the region are that they provide a means of transporting the viruses to the region and could become established and disseminate the viruses. Objectives The project will produce an internationally authoritative protocol for detecting and identifying Xiphinema americanum-group virus-vector nematode species for incorporation into the set of diagnostic protocols on quarantine pests being developed by the EU.Work programme: The meet this objective the partners in the project will:1) rationalise the 44 putative morphospecies in the X. americanum-group;2) evaluate the virus-vector abilities of the most
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Light'11: Turn on the light on Science' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Light’11 is  conceived as an event driving a cultural change about researchers for the benefit of research-end users. Light’11 will take place in  Rome, the capital of the country, and in 4 additional locations in the South of Italy thus covering large part of the country. Light’11 makes scientists from all over Italy converge to Rome, Benevento, Cosenza, Palermo and Bari. Light’11 will last from 5.p.m. on 23 September  to 1.a.m on 24 September.Light is celebrating its 4th year of life. As in previous editions, we dedicate the RN to a specific theme. This year Light’11 is dedicated to: “Real science and TV fictions” in order to show that real scientists may be as interesting and attracting as those proposed by TV fictions and that science is continuously shaping our daily existence in order to improve the understanding of the world around us and to stimulate curiosity for further developments. We will use the protagonists of science-related TV shows as a springboard for dialogue with the public in order to improve the image of scientistsIn order to ignite people’s curiosity towards scientists’ work, Light’11 will set-up a number of actions/events during the whole RN. The actions will be run in continuation in all the locations allowing  visitors to freely pass from one area to the other without waiting for something to happen.The activities will be organised around 5 main areas:oHands-on workshops with live demonstrations and hands-on experiments;o“Big ideas from young minds” area, where potential tomorrow's scientists will present their special achievements;o“Globe Science Theatre” where groups of artists/sportsmen that have at least one member of the performing team actively engaged with scientific research will be on stage during the whole RN;oOutside activities on s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Invariant visual object representations in the early postnatal and adult cortex: bridging theory, model and neurobiology' (LEARN2SEE), addressing dissemination and exploitation.

assistant: **Impact**

Our visual system can effortlessly recognize hundreds of thousands of objects in spite of tremendous variation in their appearance, resulting, for instance, from changes in object position and pose. Achieving such an invariant representation of the visual world is an extremely challenging computational problem that even the most advanced artificial vision systems are not fully able to solve. This is why understanding the neuronal mechanisms underlying object vision is one of the major challenges of systems neuroscience and a crucial step towards developing artificial vision systems and visual prostheses.Little is known yet about how the brain develops and maintains invariant object representations. The leading theory is that visual neurons exploit the spatiotemporal continuity of visual experience (i.e., the natural tendency of different object views to occur nearby in time) to learn to produce similar responses for temporally contiguous stimuli, so as to factorize object identity from other variables (such as position, size, etc.). This Unsupervised Temporal Learning (UTL) strategy has been instantiated in a number of computational frameworks, but its empirical investigation has received little attention. My proposal will use the visual system of the rat to address key questions about the nature of UTL and other learning theories, such as their impact on recognition behavior and object representations at both single-neuron and population level, and their role during early postnatal development. This will be achieved through a highly multidisciplinary approach, including high-throughput behavioral testing, in vivo neuronal recordings, immediate-early gene labeling, controlled-rearing in virtual visual environments, and computational modeling. This will lead to ground-br
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Addressing the dual emerging threats of African Swine Fever and Lumpy Skin Disease in Europe (DEFEND)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The DEFEND consortium will target two viral diseases of livestock which are emerging into Europe – African swine fever (ASF) and lumpy skin disease (LSD). African swine fever virus (ASFV) is the causative agent of ASF, a highly contagious disease of domestic pigs which causes a haemorrhagic syndrome with up to 100% mortality. ASF is endemic in sub-Saharan Africa and on the Italian island of Sardinia. In 2007 the disease was reported in Georgia. Since then it has spread to Russia, Ukraine, Poland and neighbouring countries. In 2017 outbreaks were reported in the Czech Republic and Romania. Wild boar are susceptible to ASFV and facilitate the continuing spread of the disease in Europe with regular spill-over into in-contact domestic pigs. The capripoxvirus Lumpy Skin Disease virus (LSDV) causes a classic systemic poxvirus disease in cattle and spreads rapidly in warm humid conditions, most likely due to insect-borne transmission. LSDV entered Europe, the Balkans and Caucasus for the first time in 2015. The ongoing epidemic has caused the deaths of thousands of cattle through mortality and eradication campaigns. ASFV and LSDV represent an immediate and serious threat to the pig and cattle industries in Europe and eastern and central Asia. The aim of the consortium is to control the growing LSD and ASF epidemics in Europe and neighbouring countries by understanding the drivers of LSDV and ASFV emergence, and generating research outputs which underpin novel diagnostic tools and vaccines and authenticate appropriate and rapid responses by decision-makers. A multi-actor approach will be incorporated as a central tenant of the project, with collaborations between experts from academia, industry, and government bodies including EU and non-EU partners from countries affected or t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Comparative imaging study of the trafficking and processing of gamma-secretase substrates', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Regulated intramembrane proteolysis (RIP) is of emerging importance in a broad range of physiological processes by abrogating or initiating downstream signalling events.beta-Secretase is by far the most diverse RIP mechanism if not only for the many substrates it targets. It consists of a catalytic component, presenilin that requires nicastrin, pen-2 and aph-1 for activity. The targets of beta-secretase are type I transmembrane proteins with the prerequisite however of ectodomain shedding.Since most of these substrates somehow function as cell surface receptors, we hypothesize that regulation of their dual processing essentially occurs at the surface or en route to the endosomal system. In most cases, little is known about the co-distribution of different substrates or their spatial organization between the different microdomains including their individual routes of entry in the cell.Moreover, as evidenced from the analysis of PS deficient cells, we postulate that a crosstalk exists between presenilin and/or presenilin-associated beta-secretase activity and sorting/internalization of substrates.To address these questions, we aim for a comparative imaging analysis of three known substrates, i.e. the amyloid precursor protein (APP), Notch and the more recent p75 neurotrophin receptor, p75NTR. For these substrates, their incorporation or exclusion from lipid rafts as well as their routes of entry will be under focus.To study events at the cell surface, we will establish a cell-free assay of isolated plasma membranes heets derived from wild-type, beta-secretase deficient fibroblasts or neuronal cell lines. Live and confocal imaging of single and double fluorescently tagged substrates will allow us to explore the routes and delivery to the endosomal system.Finally, it is of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High throughput proteomics using accurate mass and time tags' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The environment of a given organism determines the dynamics of gene expression, post-translational modifications of proteins and their interactions. Proteomics and genomics approaches now allow capturing these dynamics, which govern the life of an organism. Proteomics is devoted to the systematic study of proteins in order to derive a global perspective of the structures, functions and regulatory mechanisms in biological systems. The proteome represents the entire protein complement of a cell or a tissue a t a given time, in given environmental, physiological and/or pathological conditions. The dynamic nature of the proteome constitutes one of the major hurdles of proteomics analyses. Whereas the analysis of a single sample can potentially provide all the genetic information about an organism, a multitude of analyses in various conditions are necessary for proteome studies. Recent years have seen an intensive development in proteomics methodologies.Among these, accurate mass and time (AMT) tag based proteomic is particularly promising to provide extensive proteome coverage with high throughput. An AMT tag database is established by using standard proteomics methods to identify peptides and their parent proteins. Identifications are then validated using accurate masses obtained by Fourier Transform Mass Spectrometry (FTMS) and Liquid Chromatography (LC) retention times. The AMT tag database obviates the need for MS/MS in all subsequent analyses, providing the basis for throughput improvements. We are getting involved in a large-scale effort to implement and develop AMT-tag based methods.Our strategy includes new technological developments and biological applications. We plan to improve the method's quantitative ability, and to promote the use of alternative ion dissociat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'eHealth Hub, The European Hub for eHealth Business Support' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The business opportunities in eHealth are equally as important as the health care challenges they are trying to solve. Therefore, the participation of this emerging industry in building a strong EU economy is potentially proportional to the impact it will have on the health of our citizens.If the eHealth market is accelerating globally, it is still up and coming in Europe and has not accelerated to its full speed. The number of EU eHealth SMEs is on the rise, investments are starting to flow, insurance companies are starting to reimburse digital solutions, and the rest of the stakeholders in the ecosystem are getting increasingly involved. NOW seems like the perfect time for a big push to support the growth of our eHealth SMEs. Europe counts a number of support initiatives for eHealth SMEs. However, they are usually local or regional, short-term, not supporting eHealth SMEs at various stages of development, lacking a strong vertical focus and never addressing all the challenges facing European eHealth SMEs. Incubators and accelerators are popping up here and there but with a limited impact: their support is short term, targets early stage start-ups, usually requires a relocation and is costly in terms of equity for SMEs. Regional development agencies are also helping start-ups in their respective backyards but they usually lack a vertical focus and a cross-border reach into 28 complicated health systems.This proposal describes the creation of a support system that is cross-border, sustainable, highly specialized on the eHealth vertical, providing long-term support at various stages of development, and addressing all the challenges facing European eHealth SMEs: finding the right business model, accessing finance, connecting with the demand side and accelerating their com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Leveraging genomic discoveries and skeletal phenotyping to improve osteoporosis patient care' (LEGENDARE), addressing dissemination and exploitation.

assistant: **Impact**

Osteoporosis is a silent, systemic skeletal disease leading to fragility fracture. While the deleterious consequences for the individual, their families and society are well established, the causes of the disease remain elusive. Despite exhaustive clinical, epidemiological and genomic research, scarce understanding of the complex underlying disease mechanisms leading to bone fragility has hindered the improvement of clinical care.  This LEGENDARE programme aims to implement a holistic integrative approach directed at discerning the underlying mechanistic pathways leading to bone fragility. The approach seeks translating genomic and imaging discoveries into meaningful clinical strategies to stratify risk; re-evaluate treatment indication; and ultimately, redefine (molecular) disease classification of patients with osteoporosis and other skeletal diseases.   LEGENDARE will progress beyond the state-of-the-art by integrating genomic information from thousands of loci (genome regions) associated with musculoskeletal traits and other diseases, into optimized polygenic risk scores providing novel biological insight about skeletal disease. Skeletal research will be brought to a new level by enriching skeletal imaging with BIG DATA obtained with advanced whole-body EOS 3D X-rays. Approaching the whole skeleton as a unified organ will allow the unprecedented study of hidden relationships across bone compartments. Further, using artificial intelligence approaches, the complexity of the skeletal system will be modelled, integrating genomic, imaging and clinical data across epidemiological cohorts and patient settings.  LEGENDARE will deliver knowledge on fundamental processes regulating skeletal fragility, unveiling new strategies for translational exploitation leading to improved
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Liberalised and Interoperable Railways' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The main objective of LIBERAIL is to make manifest the new potential of rail transport under the influence of liberalisation of the use of infrastructure.The overall workplan consists of five main tasks as follows:Task 1: Analyse the consequences of implementing Directive 91/440 (transit and access rights of railway infrastructure), recently supplemented by Directives 95/18 (licence of operators) and 95/19 (allocation and charging of capacity). Task 2: Examine performance of new operators, changes in modal split, offer of new services.Task 3: Analyse impact on interoperability, cost of using infrastructure and level of service.Task 4: Evaluate results to date from the Directives and assess medium and long term effects.Task 5: Propose corrective measures if needed and new initiatives. %FR, GR, B, ES, UK %LIBERAIL takes into account the existence of the other on going project called EUROPE-TRIP (European Railways Optimisation Planning Environment - Transportation Railways Integrated Planning). Concertation between LIBERAIL and EUROPE-TRIP will be made in order to avoid duplication of work.