RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Silicon-Organic hybrid Fabrication platform for Integrated circuits' to be submitted under Seventh Framework.

assistant: **Abstract**

In the SOFI project, new active optical waveguides and integrated optoelectronic circuits based on a novel silicon-organic hybrid technology are introduced. The technology is based on the low-cost CMOS process technology for fabrication of the optical waveguides - allowing for the convergence of electronics with optics. It is complemented by an organic layer that brings in new functionalities so far not available in silicon. Recent experiments have shown that such a technology can boost the signal processing in silicon far beyond 100 Gbit/s - which corresponds to a tripling of the state-of-the art bitrate.SOFI focuses on a proof-of concept implementation of ultra-fast ultra-low energy optical phase modulator waveguides such as needed in optical communications. These devices will ultimately be used to demonstrate an integrated circuit enabling the aggregation of low-bitrate electrical signals into a 100 Gbit/s OFDM data-stream having an energy consumption of only 5 fJ/bit. However, the SOFI technology is even more fundamental. By varying the characteristics of the organic layer one may also envision new sensing applications for environment and medicine.The suggested approach is practical and disruptive. It combines the silicon CMOS technology and its standardized processes with the manifold possibilities offered by novel organic materials. This way, for instance, the processing speed limitations inherent in silicon are overcome, and an order-of-magnitude improvement can be achieved. More importantly, the new technology provides the lowest power consumption so far demonstrated for devices in its class. This is supported by calculations and first initial tests. The low power consumption is attributed to the tiny dimensions of the devices and to the fact, that optical switc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Regulation of endocytosis of the aquaporin-2 water channel: an interplay of phosphorylation and ubiquitination'.

assistant: **Innovation**

A proper water balance is essential for life on land and is, besides drinking water, depending on water reabsorption in the kidney. Renal water uptake depends on the expression of the aquaporin-2 (AQP2) water channel in the urinary membrane of collecting duct cells, which is critically determined by a balance of shuttling of AQP2 to (exocytosis) and from (endocytosis) this membrane. Humans with insufficient AQP2 levels suffer from Nephrogenic diabetes insipidus (NDI), a disorder in which the kidney cannot concentrate urine resulting in polyuria, while humans with increased plasma membrane abundance of AQP2 excessively reabsorb water. The shuttling of AQP2 is under hormonal regulation. Recent data showed that vasopressin (AVP) induces AQP2 exocytosis by increasing its phosphorylation at serine 256 (pS256), S264 and S269, whereas pS261 was decreased. AVP-counteracting hormones, such as dopamine and ATP, induce AQP2 endocytosis involving its temporary ubiquitination at lysine 270 (K270). The effect on changes in pS256/261/264/269, and the identity of the E3 ubiquitin ligase and deubiquitinating enzyme (DUB) are unknown. Using an ideal polarized cell model and state of the art tools and techniques, the applicant will (1) determine the relationship and order in changes in pS256/261/264/269 and ubiquitination with dopamine/ATP-induced endocytosis of AQP2, (2) investigate whether the plasma membrane expression of constitutively-phosphorylated S269 is due to decreased K270 ubiquitination, (3) search for and identify the E3 ubiquitin ligase and DUB regulating AQP2 endocytosis, and (4) investigate in what sense a mutation causing NDI (AQP2-P262L) is changed in its phosphorylation compared to wt-AQP2 and whether it explains its missorting. The anticipated data will increase the in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'SGLT2 INHIBITION FOR CARDIOVASCULAR ENDPOINT REDUCTION IN HYPERTENSION (SGLT2-HYPE)'.

assistant: **Innovation**

Hypertension (HTN) is a leading cause of cardiovascular disease (CVD), affecting >80 million EU citizens and >50% of people aged >65 years, resulting in 1 million deaths per year, predominantly from CVD and chronic kidney disease (CKD). The damage done by CVD costs almost €300 billion annually in the EU alone. Despite existing therapies, patients with HTN still face substantial risks, due to pre-existing and ongoing end-organ damage due, in part, to inadequate blood pressure (BP) control. SGLT2 inhibitors (SGLT2i) are recommended for both type-2 diabetes and heart failure to reduce morbidity and mortality. SGLT2i reduce BP and might also improve outcomes for HTN by reducing end-organ damage through diverse other actions. However, confirmation that SGLT2i are clinically useful for the management of HTN is required to change guidelines and clinical practice. Therefore, we designed a multicentre, double-blind, randomised, placebo-controlled trial (SGLT2-HYPE), comparing the effects of dapagliflozin to placebo in people with inadequately controlled HTN, aged ≥65 years and with at least one other CVD or risk factor. The primary endpoint is a composite of CVD and CKD morbidity and mortality; a key secondary endpoint assesses quality of life. With 5,792 participants, assuming an annual placebo event rate of 2.5% compared to 2% with SGLT2i, a 3-year recruitment period and a minimum follow-up period of 4 years (7 years in total), the trial has 80% power for p<0.05 (two-sided). This guideline-relevant trial will inform guidelines and practice and may introduce a new therapeutic class for HTN, enhancing the current standard of care for an extremely common, treatable cause of CVD/CKD to reduce or prevent morbidity, disability and death. By engaging with key stakeholders, the trial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Autonomous sensorized rollers for industrial conveyors for failure early detection' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Conveyors are the most common system to move materials in different sectors like: mining, steel, chemical, thermal, etc...Fuel prices and difficult access places make conveyors the best option not only in terms of speed or convenience but mainlydue to economical reasons.However, conveyors suffer from a pandemic disease: their rollers. Every conveyor is mainly composed of three kind ofcomponents: rollers, belt and drums. The rollers are the main critical part, suffering from corrosion, abrasion and the contactof the materials which are being transported make the rollers collapse. Their lifespan is very dependent on the environmentand the materials carried, but the results are always fatal: belt deterioration and sudden stop of the whole conveyor. Takinginto account that the average conveyor length is more than 10Kms (reaching in some cases 100Kms) and that manyconveyors operate 24x7, the economic losses of an unexpected stop can reach to millions of Euros.Nowadays, in order to diagnose a possible roller failure and detect it as soon as possible there are several methods, amongthem the most widespread is a visual test. These tests involve several inaccuracies as the measures are done by ear whichis open to human errors, lack of precision and obviously lack of objectivity between different cases.ULMA Conveyor Components is an SME devoted to the design, manufacturing and commercialization of conveyorcomponents, in the year 2012 the R&D department started a new project to offer their customers the best in class rollers toavoid unexpected stops. The developed rollers (GaZiMo), with the first prototype recently implemented and tested,incorporates sensors, a communication module, an autonomous energy generation and a new design in order to obtain inreal time the technical param
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Virtual Integrated Partnering (VIP) for SME service, technology and information providers in the European maritime sector' to be submitted under Seventh Framework.

assistant: **Abstract**

EuroVIP aims to co-ordinate European maritime SMEs, associations, larger companies, and research institutions to promote the application of research results and innovative technologies in SMEs, by service, technology and information (STI) transfer in terms of operational and technical collaboration support. It will provide a viable and sustainable means for the exploitation of outputs from past, present and future projects.Collaboration through the exchange of industrial and research innovations is a key factor in achieving the competitive benefits that globalisation can bring to maritime organisations. However, achieving successful awareness and effective collaboration remains a significant obstacle. There is a clear need for European SMEs to fully engage with each other and to adopt a more advanced approach with regard to the exploitation of innovations through the development of collaborations on a grander geographical scale.A concerted co-ordinated activity is needed to exploit innovations, making them widely available and supporting their use throughout Europe. Conventionally this would be achieved through knowledge exchange workshops to facilitate networking amongst interested organisations. EuroVIP takes a novel state-of-the-art approach to Virtual Integrated Partnering (VIP) and collaboration for the exchange of advances and innovations, coupled with workshops, demonstration “road shows”, and meetings to bring together research outputs and expertise for exploitation.The project will identify technologies with the highest potential impact and build partnerships for the exploitation of such. Best collaborative practice will be disseminated to facilitate SMEs in finding the right partnership, right innovations at the right time, and to configure and enable such par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Graphene-Based Ultra-Sensitive Gas Sensors' to be submitted under Seventh Framework.

assistant: **Abstract**

Goal of the proposed research is to transfer the knowledge of experienced researcher to Europe. Detection of minor gas leaks in a hazardous work environment has been a challenging research problem for many decades as it involves health, safety and environmental risks. In this proposed research we will develop graphene based gas sensors with ultrafast response, high sensitivity, great selectivity and high durability to detect the environmental pollutants even in very low concentrations. We intend to target the detection of various toxic gases such as CO2, CO, H2S, NOx, ethanol, and SO2 in ppb level. Graphene is relatively a new material to be used for practical sensor purpose. The idea underlying the selection of graphene for sensor application is its variable conductivity, which makes it available for electron transport phenomena with very high electrical mobility in the presence of oxidizing and reducing gases. The feature of high conductivity will be exploited by using graphene as conductivity-based chemical gas sensors. The proposed study will allow the optimization of sensor parameters for making sensors with good selectivity for target gases by using metal catalyst such as Pt, Pd, and Au on the surface of graphene. The idea underlying the present proposal is that by coating graphene with metal nanoparticles, one could increase the effective surface area and modify the work functions, thereby improving the sensitivity and selectivity of the gas sensors. Successful completion of this research will have enormous benefit to European society through numerous applications, including the reduction of health risks and improvement of public security, detection of environmental toxins and semiconductor processing. Researcher Dr. Rakesh K. Joshi is expert in nanomaterials syn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Researcher's Night in France' (CREATIVITY).

assistant: **Concept**

We are proposing ERNs for 2016 and 2017 in 12 French cities. Our consortium of 11 partners will organise afternoons for schoolchildren, events in the cities and, above all, evenings where 1000 researchers will meet up to 30,000 people a year. The general public will be able to meet a number of researchers directly and experience something memorable with them. Since 2006, we have acquired a solid knowhow in the “art of interaction”. In 2014-2015, we went one step further by including the public in the actual research experiments, thereby creating scientist-citizen cooperation. We will renew these experiences and go even further: we are encouraging the public and researchers to experience creative moments together!Several creative interactions will be set up, around the “Ideas” theme in 2016 and the “Impossible?” theme in 2017, to allow researchers and the public to interact.The evenings will be full of ideas, challenges, and encounters with diverse individuals. In this way, we will rally European researchers to get involved in each city. Specific strategies will be used (such as public radio recordings) to allow them to share their European experience.These moments of cooperation will without a doubt reinforce the mutual appreciation between researchers and citizens. Our communication strategy (attracting specific audiences through networking, web, partnerships with youth-oriented press, etc.) will be based on the slogan: “General Creativity”. This slogan denotes the interactive nature of the evening and gives us a chance to talk about the richness of European research. To this effect, and for the first time, Cédric Villani, an inspiring and renowned researcher, has accepted to be the ERN’s patron. Lastly, we plan to renew the “Great Participatory Experiment” in 2017. In
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Targeting Purinergic Pathway in drug-resistant epilepsy using human Neurons and Glia.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Epilepsy is a neurological disorder characterized by recurrent seizures affecting 65 million people worldwide of which 6 million live in Europe alone with around 30% of patients not responding to currently available treatment. The ATP-gated P2X7 receptor (P2X7R) has recently emerged as a promising target for epilepsy, showing anticonvulsant and disease-modifying properties in animal models. However, to develop P2X7R-based therapeutics the cell types involved in pathological P2X7R activation must be determined, and whether results from rodent models can be replicated in human tissue must be tested. Using human induced pluripotent stem cell-derived neurons and glia and resected brain tissue from epileptic patients, TaPPiNG-EPI proposes to investigate the cell-specific alterations and pathological contribution in the P2X7R pathway and pharmacological targeting of hyperexcitability using P2X7R antagonists. These studies will be complemented by the investigation on the alterations in P2X7R pathway in GFP-P2X7 reporter mice available in the host institution (RCSI). Through international secondments and intersectoral collaborations TaPPiNG-EPI brings together experts in purinergic signalling, industrial partners, epilepsy clinicians as well as leading European academic labs with diverse expertise. The interdisciplinary and intersectoral components of TaPPiNG-EPI combined with international collaborations and secondments in academia, the excellent training record of the supervisor and RCSI and the outstanding resources for learning and development available at RCSI will give me the tools necessary to achieve research independence and my transition to a highly employable future neuroscientist with a focus on epilepsy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bench-top system for detection and analysis of miRNA using solid-state nanopores' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The fast and reliable detection of single molecules holds the promise of revolutionising diagnostics, disease prevention as well as biological research by offering unprecedented resolution compared to bulk approaches. Based on work done as part of the ‘DesignerPore’ ERC consolidator grant (Nature Nanotechnology 2016) we will develop a benchtop device capable of detecting hundreds of molecular targets within tens of minutes. We will combine our recent development in nanopore sensing technology (JACS 2015) with machine-learning (Nano Letters 2018) and advanced statistics (arxiv 2019) to create a new versatile single molecule technique. Ultimately, our PoreDetect technology has the potential to become an integral part of handheld or wearable devices allowing real time tracking of disease markers for personalised medicine, bacterial infections or environmental contaminants. While the technique is not limited to the detection of certain molecules, for this proof-of-concept we aim to focus on sensing short oligonucleotides tens of base pairs in length, with immediate applications in the quantification of cell-free (cfRNA) and microRNA (miRNA) as cancer biomarkers.


**Keywords:** Nanopore sensing, Single molecules, Nanotechnology, Bionanotechnology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Scaling Up secure Processing, Anonymization and generation of Health Data for EU cross border collaborative research and Innovation' (SECURED) targeting Horizon Europe.

assistant: **Abstract**

The overall goal of the SECURED project is to scale up multiparty computation, data anonymization and synthetic data generation, by increasing efficiency and improving security, with a focus on private and unbiased artificial intelligence and data analytics, health-related data and data hubs, and cross-border cooperation. The project will address the limitations that are currently preventing the widespread use of secure multiparty computation and effective anonymization, namely: the limited practical capabilities of current cryptographic schemes for secure multi-party computation protocols, and their performance; the lack of well understood and standardized data anonymization methods for health data; the absence of dynamic and on demand services for generating synthetic data; the complex and ad-hoc nature of current federation protocols for machine learning and AI-based data analytics; the lack of support for health technology providers to implement privacy enhancing technologies, in particular SMEs.SECURED will tackle these challenges by focusing on scaling up privacy technologies via algorithmic improvements and implementation efficiency (HW and SW), as well as the generalization of primitives and definitions, with the aim of speeding up and facilitating privacy preserving data-driven tools and services for wellbeing, prevention, diagnosis, treatment and follow-up care. SECURED will also analyse the current ethical and legal challenges to data sharing, and is targeted at overcoming current limited adoption of advanced multi-party computation and data anonymization technologies by providing direct support to health technology SMEs through a funding call. To ensure relevance to real-world settings, SECURED will showcase the technologies developed in four health-related