RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Numerical models of black hole systems as sources of gravitational radiation'.

assistant: **Concept**

With the completion of the first scientific data runs at the ground-based interferometric gravitational wave detectors, the day is quickly approaching when we will have the first confirmed observations of gravitational radiation. The coalescence of galactic binaries containing two black holes is a prime candidate for observation by the detectors, due to the relative strength of the gravitational wave signal from such an event.With that in mind, one of the primary research topics in general relativity has be en the numerical modelling of a space-time constaining two orbiting and merging black holes. To this day, the general relativistic two-body problem remains unsolved; the complexity of the highly coupled non-linear field equations requires non-trivial numeric al solutions. The proposed Incoming International Fellowship will support a researcher working in collaboration with the relativity group at the Observatory of Paris at Meudon for the purpose of developing and implementing a stable, accurate numerical code to model two inspiralling black holes.The model will be based on a constrained scheme developed by the Meudon group, which introduces a Dirac gauge and maximal slicing conditions in spherical coordinates to formulate Einstein's equations as quasi-linear elliptic equations and wave equations. The collaboration will advance the fields of relativity and gravitational wave astronomy within Europe while providing support for the professional development of the researcher and the enhancement of scientific excellence at the host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'MAGIC-SWITCH: Magnetic Switch Controlled with Voltage'.

assistant: **Objectives**

We are living in a world that is increasingly driven by data. Governments, healthcare facilities, commercial businesses and individuals are all storing information in electronic form. This has led to the emergence of digital and cloud-based technologies. The ability to use information more efficiently has resulted in a rapid increase of the value of information. However, with the Big Data revolution, information is facing new challenges. Energy efficiency during writing of magnetic information needs to be improved. Thus, enhancing robustness in data storage systems is one of the major challenges in our modern society. Our vision for the near future is to turn the scientific output of the ERC Consolidator SPIN-PORICS into a new type of storage memory. MAGIC-SWITCH will deliver the prototype and business case for a new type of compact storage memory, at an industrial-relevant scale. The specific goal of this PoC project is to take the initial steps towards this vision by building a prototype (moving from Technology Readiness Level TRL 3 to 5), standardizing its manufacturing process and creating a business case for its commercial exploitation (including a pitch that can be used to close new partnerships or in fund-raising).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'IMplementing Innovation Strategies - IMIS'.

assistant: **Innovation**

The aim of our proposal is to help regions analyze and implement regional innovation actions and schemes, the way they have been shaped by the regions and according to the priorities that have demonstrated. However, IMIS project will also try to advice r egions (without any political risk) to adopt actions and measures that promote the local knowledge base, and networking and bring on the surface the local tacit knowledge potential. Having worked for a long period in this area, the IMIS management team a nd experts group takes into consideration various factors in order to shape the main objectives of the IMIS proposal. These are: - To identify the local contact points for the implementation of the regional innovation measures - To identify the maturity level of the measures in order to propose the relevant expert work - To map the regional needs according to the proposed actions, maturity level political involvement and commitment, in collaboration with those developed the RIS-NACs Action Plans and the IRE secretariat. - To elaborate and create a continuously updated database of expertise and experts that could promote appropriate counseling schemes that helping towards the implementation of the actions. - To cover significant expert areas that show in creased density of counseling needs. These areas match with the proven track record of our experts in developing relevant innovation policy schemes in the EU and in transferring excellence among E.U. members and in NACS. - To support the counseling servic es with enriched activities, outside the core thematic expertise. Such activities are awareness raising, visiting schemes organization, project planning and organization (GOPP), events on regional entrepreneurship promotion etc. - To create a continuous mo mentum of inf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Advanced Safety Assessment : Extended PSA'.

assistant: **Concept**

The Fukushima nuclear accident in Japan resulted from the combination of two correlated extreme external events (earthquake and tsunami). The consequences (flooding in particular) went beyond what was considered in the initial NPP design. Such situations can be identified using PSA methodology that complements the deterministic approach for beyond design accidents. If the performance of a  Level 1-Level 2 PSA concludes that such a low probability event can lead to extreme consequences, the industry (system suppliers and utilities) or the Safety Authorities may take appropriate decisions to reinforce the defence-in-depth of the plant. The project ASAMPSA_E aims at identifying good practices for the identification of such situations with the help of Level 1-Level 2 PSA and for the definition of appropriate criteria for decision making in the European context. It offers a new framework to discuss, at a technical level, how extended PSA can be developed efficiently and be used to verify if the  robustness of NPPs in their environment is sufficient. It will allow exchanges on the feasibility of “extended PSAs” able to quantify risks induced by NPPs site (multi-units reactors and spent fuel pools, modelling impact of internal initiating events, internal and external hazards on equipment and human recovery actions …).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interfacial Engineering in Copper Carbon Nanofibre Composites (Cu-C MMCs) for high thermally loaded applications' (INTERFACE).

assistant: **Innovation**

The main objective of INTERFACE is to gain the necessary knowledge to engineer the interface of Cu matrix composites reinforced by carbon nanofibres, to develop a low-cost material with a dramatically improved thermal conductivity. For these fundamental interfacial studies a two phase concept is proposed: first, studying of interfacial properties and possibilities to modify them on flat carbon samples; and second: transfer of this knowledge to real nanofibres. With the availability of high thermal conductivity carbon nanofibres in kilogram batches and at an affordable price they have become promising candidates for the reinforcement of copper matrix composites to give a material combining high thermal conductivity and a tailored Coefficient of thermal expansion (CTE), suitable for heat sink applications. However, the thermal transport across the C-Cu interface is very low and has limited the full potential of this type of materials up to now. INTERFACE aims to radical improvements in this field by: - Fundamental study of the heat transfer at the copper/carbon interface using flat model systems - Identification of possible interface modification strategies by introducing nanometre thick interlayers to optimise the mechanical and thermal interfacial properties. - Functionalisation of the surface of C nanofibres using the concepts developed in the flat model systems - Understanding the role of interfaces in the thermo-mechanical properties of Cu MMCs reinforced with C nanofibres - Preparation of composite material incorporating the interfacial functionalisation achieved. - First assessment of performance of the composite for different high thermally loaded applications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Molecular Mechanisms of Cell Fate Reprogramming in Vertebrate Eggs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Vertebrate eggs can induce the reprogramming of transplanted somatic nuclei to enable the generation of all cell types of a cloned organism. However, the efficiency of nuclear reprogramming is low, and only a small proportion of the nuclear transfer embryos generated from differentiated cells reach a reproductive adulthood. How the egg achieves the erasure of the previous somatic cell identity and the establishment of totipotency only in some instances remains a question of fundamental importance. Epigenetic modifications were shown to be major roadblocks to reprogramming, but how these roadblocks resist removal by the egg factors and how they are instead propagated during early embryonic cell divisions to induce inappropriate expression of genes in nuclear transfer embryos is not known. This proposal aims at identifying the molecules in the egg that a) help to overcome the epigenetic barriers during successful reprogramming events and b) cause resistance when reprogramming fails. We will then c) interfere with these mechanisms to improve cell fate conversion. The gained molecular insights into cell fate reprogramming via the natural activities present in the egg can then be utilized to develop efficient reprogramming strategies for therapeutic purposes such as enhancing regeneration or improving cell replacement therapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mass spectrometry assisted sustainable green approaches for food safety and authenticity' in the context of a Horizon Europe call.

assistant: **Objectives**

The agri-food chain from the original product to its commercialization has thorough controls. Authenticity and food safety are highly supported by protocols and are legislated by different organizations. PlasMOF aims to propose novel cutting-edge solutions based on state-of-the-art mass spectrometry (MS) and novel design materials. The use of novel ionization methods based on dielectric barrier ionization (DBDI) and green sample preparation techniques enhanced by using Metal-Organic Frameworks (MOFs) may provide unprecedented advantages in solving relevant food quality and safety. This project proposes novel approaches based on the synergic use of advanced materials and ambient mass spectrometry for some of the challenges that need to be addressed in the agri-food sector related to their quality, authenticity and safety. PlasMOF proposed the synthesis, characterization and application of Metal-Organic Frameworks (MOFs) as novel sorbent materials in miniaturized solid-phase schemes (SPE). In a second stage, the elaboration of novel devices based on MOFs and their combination with DBD-based ambient ionization methods for relevant societal applications. Different DBD-based tools configurations will be tested as ionization methods in food authenticity (including two-ring electrode DBDI, flexible microtube plasma (FTP), active capillary sampling plasma source (ACaPI) and low-temperature plasma (LTP)). These novel technologies will be implemented for the assessment of virgin olive oil VOO authenticity and to detect frauds in VOO and in other food products such as wine.


**Keywords:** Dielectric barrier discharge,  metal-organic frameworks,  agri-food
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advance in Proteomics and Analysis of dyes and Recovery of Charred and Aged textiles' (PARCA) targeting Horizon 2020.

assistant: **Abstract**

The analysis of archaeological textiles is a challenging undertaking. These precious remains have been altered to the point that discerning their composition requires the development of high specialised analytical tools, characterized by high sensitivity and great versatility. In different sites, many textiles have been excavated, some well-preserved, some with signs of carbonisation; in some cases, traces of colour are still visible. PARCA project proposes to join forces between dye analysis and proteomics to develop an innovative streamlined protocol that would combine dye and protein analysis in a single extraction to minimise sampling size while maximising the amount of information obtained. It will be achieved through the most up-to-date methodologies and instrumental developments of Liquid Chromatography-Orbitrap-Mass Spectrometry to develop protocols that will be applicable to the most degraded archaeological textiles. The LC-MS data will be correlated with FTIR and SEM analyses, to determine the threshold of protein survival by non-destructive techniques prior to proteomics. The project will be carried out for the first 2 years at the Smithsonian Institution (Washington DC-USA), in the proteomics lab under the supervision of Dr. Caroline Solazzo. The third year, incoming phase, will be carried at Sapienza University of Rome, under the supervision of Prof. Roberta Curini. At the end, archaeological relics from the Mediterranean basin will be analysed, in particular samples from Pompeii and Vesuvian areas and from Greek areas. The success of this project will result in gaining new experience in the analytical characterization of ancient textiles, by enriching my background on dyes with the acquisition of a very high level of skills in the field of proteomics and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fecal miRNAs, new mediators of host-microbiota interaction in Inflammatory Bowel Disease' under Horizon 2020.

assistant: **Concept**

Growing evidences indicate that microRNAs (miRNAs) are present in various body fluids and contribute to cell-cell communication. My previous studies identified circulating miRNAs as efficient tool for the diagnosis and surveillance of Inflammatory Bowel Disease (IBD). Interestingly, miRNAs are secreted into the intestinal lumen where thousands of different bacterial species are present and confer important benefits to the host. This proximity prompted us to speculate that miRNAs and bacteria interact, playing a role in the host/microbiota relationship. My preliminary data generated to date demonstrate that fecal miRNAs are altered during intestinal inflammation in association with an alteration of microbiota composition, and we recently reported that exogenously administered miRNAs have the potential to alter microbiota composition and function. Here, our central hypothesis is that fecal miRNAs are mediators of host-microbiota interactions and therefore modulate intestinal inflammation. On the basis of this overarching hypothesis, I now propose to determine the role played by the intestinal microbiota in miRNA-mediated modulation of intestinal inflammation (objective 1: mechanism); Investigate the ability of specific miRNAs / anti-miRNAs to modulate intestinal inflammation. (objective 2: therapeutic) and to identify whether fecal miRNAs are indicators of microbiota and intestinal healthiness in IBD patients (objective 3: translational). We envision that the proposed experiments could identify a new role for miRNAs in manipulating the intestinal microbiota hence leading to the development of new therapeutic strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of an oral anti-norovirus therapy' in the context of a Seventh Framework call.

assistant: **Objectives**

Often reported in the public press as “Stomach Flu” or “Winter Vomiting Disease”, noroviruses are the leading cause of gastroenteritis in the developed world, with frequent outbreaks in closed environments (e.g. hospitals, schools, etc). Outbreaks in hospitals result in substantial economic losses (>100 million € per year in UK), but more importantly put additional pressures on health care services. With the ongoing influenza virus pandemic, it is essential health care services run efficiently, however the winter seasonal peak of norovirus outbreaks will coincide with that of influenza virus and will undoubtedly have a major impact on hospital facilities. Hence new antiviral strategies against noroviruses are essential, yet there are currently no effective treatments to control these pathogens. This proposal aims to explore the use of a new potential antiviral approach based on inhibitory RNA aptamers. Aptamers are single-stranded nucleic acids selected by robotic procedures to have high affinity for a target molecule and its binding often results in specific inhibition. Norovirus replication is catalysed by viral polymerase which may constitute an attractive target for anti-viral therapy. We will identify aptamers against polymerases from 2 different noroviruses: Norwalk virus, the prototypic human virus, and murine norovirus (MNV), that provides us with cell culture and in vivo systems to study norovirus replication. We will investigate if administration of aptamers in mice prevent establishment of MNV infections in vivo. For an efficient delivery of aptamer RNAs to the intestinal tract we will make use of a newly developed technique reliant on invasive non-pathogenic bacteria that enter intestine cells to express therapeutic RNAs. This approach will constitute a proo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Transitioning Psychotropic Alkaloids From Plants And Mushrooms To Neuroprotective Agents: Incorporating Computational Tools For The Development Of Novel Therapeutics' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The NeuroHEALTH project aims to address the growing challenge of neurodegenerative diseases, such as Alzheimer's and Parkinson's, which affect millions worldwide and impose significant social and economic burdens. The project will harness the potential of neglected natural products (NPs), like alkaloids, from psychotropic plants and mushrooms that till recently had regulatory constrains.  The integration of state of the art phytochemical analysis,  with advanced computational tools will accelerate the discovery of novel NPs. In vitro and in vivo testing assays including  zebrafish models will evaluate the safety and efficacy to reveal compounds of interest, that can enhance cognitive health and improve quality of life. Bioactive extracts and NPs will be scaled up and formulated in combination with a market analysis, sustainability and intellectual properties assessment will ensure that findings are relevant and applicable. Through strategic secondments and staff exchanges among academic and industry partners, NeuroHEALTH will foster interdisciplinary collaboration, enhancing knowledge transfer and innovation. Workshops, conferences, and outreach activities will engage diverse stakeholders, including professionals, policymakers, and the general public, promoting awareness of the project's findings and their implications for health care. By bridging the gap between traditional knowledge and modern science, NeuroHEALTH aims to deliver impactful solutions for neurodegenerative diseases, ultimately contributing to healthier aging populations. This timely initiative not only addresses urgent societal needs but also positions Europe at the forefront of innovative research in natural product-based therapeutics.


**Keywords:** Natural Product Chemistry, chromatography, bioinfor