RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Photochemical activity and ultraviolet radiation modulation factors.' in the context of a Fourth Framework call.

assistant: **Objectives**

The proposed research aims in the first place at quantifying the hierarchy of UV-B modulating factors moving from startospheric ozone to tropospheric ozone and other environmental factors such as aerosol, clouds and air quality. This project builds on recent results from EU campaigns which have shown that southeastern Europe and particularly the Aegean sea, is experiencing enhanced background ozone up to the tropopause, with extreme gradients in the J(O1D) prevailing in the first 2 km above sea level in the region. Therefore the project in addition to quantifying with model results validated by calibrated observations the factors influencing UV transfer, it will next move on to unravel the mechanisms maintaining the high background ozone over Southeastern Europe and its interplay with UV transfer. 3-D model studies will be done in large regional and subregional scales to understand the extend of enhanced background ozone and its sources. The tropospheric effect on UV transfer is not as large as the absorption in the stratosphere but can be important due to photon path enhancements in the presence of different types of aerosols. This synergistic effect of the aerosol burden will be separately studied, being at present an open question. The above objectives of the project will be achieved through extensive state-of-the-art campaign measurements and modelling studies. The sites selected (islands of Crete and Lampedousa)are both in central and eastern Mediterranean and provide unique environments to meet the objectives presented before. They are located in the sunniest part of Europe and are exposed to high background levels and to alternating types of aerosols (Sahara/maritime) for which the quantification of combined effects are targeted in the study. The campaign and mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Propagation of cellular memory through dormancy'.

assistant: **Concept**

Decades of work established the importance of dormant cells in reproduction and regeneration, however, a central unsolved question is how the cell propagates transcriptional memory and cellular identity through dormancy. Current approaches tend to characterize dormancy as a binary on-off switch. In contrast, a highly coordinated and precisely timed set of events are needed to successfully transition cells into dormancy, to maintain dormancy, and to exit it. In DOR-CODE, I will leverage the latest gene editing and genome profiling tools on an inducible and reversible embryonic dormancy model that I spearheaded (Bulut-Karslioglu et al, 2016, van der Weijden et al, 2022) to discover the genomic basis of dormancy. My mission is to reveal the temporal regulatory code of dormancy - ‘DOR-CODE’ - without which cellular identity cannot be propagated through time.Recent work by us and others has started to reveal the epigenomic landscape of dormancy: a highly repressed state with elevated DNA and histone methylation and decreased transcriptional output. Cellular strategies to counteract this overall repressive state at regulatory sites at the correct times are key for the retention of developmental potential. Here, I will identify DNA and histone demethylation strategies to propagate transcriptional memory at key regulatory elements (Objectives 1&2) and connect locus-specific regulation (Objectives 1&2) to genome macro-organization (Objective 3). By building direct links between anabolic growth and genome regulation, I will demonstrate how timely gene reactivation is ensured to enable exit from dormancy. The conceptual leap and mechanistic insights resulting from DOR-CODE will (1) enhance our knowledge of embryonic dormancy and lay the foundation for better in vitro embryo preser
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding of the Physics of Wind Turbine and Rotor Dynamics through an Integrated Simulation Framework', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Wind energy is the largest of the new renewable energies and traditional wind turbine design has reached maturity, but still improvements can be done through better understanding of the physics for the entire wind turbine system. At the same time demand for more green energy, requires new turbine designs with improved environmental characteristics, adaptable to new locations, etc.In the UPWARDS project the goal is by the help of high performance computing (HPC) to develop a simulation framework, which will incorporate a more complete description of the wind field, turbine, the support structure, etc. and their interaction in order to better understand the physics of the entire system. The complex wind field will be calculated adding interactions from nearby turbines, waves, terrain, etc.The simulation framework will yield more accurate prediction of the forces acting in the system and thus the energy captured by the turbine. In addition, it will better predict acoustic phenomena, and materials issues related to the turbine blades, etc. The platform will be modular and new design will be relatively simple to introduce.An important part of the project is to evaluate the socio-economic impact and to bring user communities into the project development.Altogether this will improve the design development process and allow for faster implementation of new and more advanced designs with less environmental impact. It will also improve the accuracy in power production.The methodologies and major results from the project will be published in open access journals or freely accessible reports. In addition an open database containing relevant results and raw data will be established. This will enable other researchers and turbine developers to utilise the results for further studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spin based quantum computer and simulator (SPINUS)' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The SPINUS project aims to establish experimental platforms for both quantum simulation (with >50 quantum units) and quantum computation (with >10 qubits). Despite rapid advancements, scaling and implementing quantum simulators and computers towards a regime surpassing available classical methods remains difficult due to the demanding constraints of existing architectures. By utilizing the exceptional qualities of silicon carbide (SiC) and diamond materials, the SPINUS project suggests a novel strategy for scalable solid-state quantum simulation and computation hardware based on nuclear spin networks and dipole-dipole entangled electron spin qubits. Our first goal is to create a quantum simulation platform that uses optically polarized NV centers and color centers along with nuclear spin networks in diamond or SiC. This technology allows for the investigation of a wide range of strongly correlated models without being constrained by the capabilities of the available quantum simulators. Second, we aim at scaling up platforms for solid-state quantum computing to more than 10 fully programmable qubits at ambient temperatures. For these purposes, the consortium will investigate various architectures and techniques for initializing, controlling, and reading out the spin qubits with the goal of achieving large-scale quantum simulation and computation capabilities. This will take advantage of the excellent coherence properties and robustness against environmental noise of these materials.SPINUS has great potential to advance the field of quantum computing and simulation and open new possibilities for the investigation of intricate quantum systems by fostering and contributing to a European quantum and a European diamond ecosystem by working closely with start-up businesses aff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'RADical reduction of OXidative stress in cardiovascular diseases' (RADOX) targeting Seventh Framework.

assistant: **Abstract**

Cardiovascular disease (CVD) constitutes a major and increasing health burden in developed countries. The prediction is that the prevalence of these conditions will increase by ~60% over the next 20 years.  Therefore, the development of novel treatments for patients with CVD becomes more and more urgent. Oxidative stress is an important molecular contributor to the pathogenesis of CVD. However, oxidative stress-related therapeutic strategies are still missing. This ITN consortium links investigators highly active in the field of oxidative stress-signalling, and will strongly enhance collaborative research and integrate complementary interests to obtain innovative science and outstanding in-depth integrative multidisciplinary training possibilities. The scientific aims of this ITN proposal entitled ‘RADical reduction of OXidative stress in cardiovascular disease (RADOX)’ are to characterize the specific sources of reactive oxygen species (ROS) and their interaction in CVD and to use this knowledge to develop diagnostic tools for the detection and quantification of ROS and their subcellular targets. This will lead to new therapeutic strategies which modulate the activity of these specific sources of ROS. This RADOX consortium, containing 9 full partners (7 academic and 2 private) and 7 associate partners (1 academic and 6 private) will train 11ESR and 4ER. The mission of this ITN consortium is to create in a period of 4-years the future leaders in this field. Our trainees will receive unequaled multidisciplinary scientific and transferable skills training which will make them ready for leading positions in academia or industry. The training in this programme will be at 3 levels i.e. through research under supervision, transferable skills and secondments and will have a st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Establishing services enhancing the innovation management capacity of SME´s in Hamburg and Schleswig-Holstein' (2014-2020).

assistant: **Concept**

The four partners Investitionsbank Schleswig-Holstein (IB.SH), TuTech Innovation GmbH (TuTech), Wirtschaftsförderung und Technologietransfer Schleswig-Holstein (WTSH) and IFB Hamburg (IFB) are part of the Enterprise Europe Network (EEN) consortium in Hamburg and Schleswig-Holstein and established a well-known regional one-stop-shop for all EU-related enquiries for SMEs and regional stakeholders.For the period 2017-18 core objective is to expand the client base and deepen the level of assistance by offering the new service of “Key Account Management” (KAM) and “Enhancing SME Innovation Management Capacity” (IMC). Aim is to face existing lack of innovation management capacity in small and medium sized companies (SME) and support their innovative activities in order to creating economic impact. The guiding principle is that the services are tailored to the needs of the identified regional innovators and innovation systems.In this context the KAM is targeted at beneficiaries of the SME instrument under Horizon 2020, the EIMC addresses other highly innovative SMEs. The EIMC helps companies to establish effective innovation management systems that enhance the realisation of growth opportunities. The KAM focuses on those weaknesses which endanger the success of the funded project. It assists in finding specialised coaches and establishing a coach-client relationship. Both approaches aim to raise the company´s competitiveness and profitability.In the framework of the project the consortium acquired user licenses for the IMP3rove tool in order to assess gaps and needs of the SMEs. In this context senior staff of the EEN attended training to ensure that the tool is used correctly and the assessment exercise complies with the envisaged EU standard. In addition the participation in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Radical Improvement of Cancer Treatment without Additional Negative Side Effects', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

We have developed a device  called HyperCollar4D  that significantly increases the effectiveness of radiotherapy for head and neck (H&N) cancer. The first results on 70 patients have proven that our technology yields +50% complete response with respect to radiotherapy alone. The HyperCollar4D is based on hyperthermia: warming up the tumor to 43 C improves its sensitivity to radiotherapy. Hyperthermia yields no lasting toxicity, unlike radiotherapy and chemotherapy. The challenge with hyperthermia is delivering it effectively (i.e., heating only the tumor and not the nearby tissues) and cost-efficiently. The HyperCollar4D is the first device to achieve effective and cost-efficient hyperthermia treatments for H&N cancer. Our technology (called thermotherapy) is protected by two patents (one granted and one filed). The HyperCollar4D design is modular, so it can be extended to add modules to treat other kinds of cancers. Sensius is a spin-off of the Erasmus Medical Center.


**Keywords:** Hyperthermia,Thermotherapy,Head and Neck cancer,Personalised treatment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Molecular Nanotechnology for Life Science Applications: QUantitative Interactomics for Diagnostics, PROteomics and  QUantitative Oncology'.

assistant: **Objectives**

The main goal of this proposal is to introduce innovative devices and protocols (based on nano- manipulation, the response of micro-(nano-)mechanical oscillators and nano-fluidics) to carry out, precise, high throughput, high sensitivity, and low cost interactomic measurements. We aim at measuring, in parallel, the concentration of up to several proteins or non-coding RNA molecules, in samples down to the single cell level, following the real time concentrations of several biomarkers in patient-derived samples down to femto-molar concentrations, and single-circulating-tumor-cell resolution. We plan to develop our program a) by applying the principles and practice of intrinsically differential measurements, e.g. by building a self-assembled nano-devices that provide robust outputs measurable with topographic AFM imaging, electrochemical measurements, or gel electrophoresis, and b) by using the vertical equivalent of cantilever oscillators (pillars) that we plan to use as quartz “microbalances” that are 10,000 time more sensitive than cantilevers w. r. t. measurable min. mass and 100 time more sensitive w. r. t. dilution. The proposal’s core strategy is to exploit the PI’s expertise in innovative instrumentation and his integrated physical chemistry know-how, leading a highly multi-disciplinary staff to closely interact with first class medical staff in hospital settings to solve, and validate the solution of, relevant medical problems by generating innovative and versatile sensing devices. For instance, the sensitivity of our sensors will allow protein or miRNA analysis from very small and homogeneous samples of tumor cells, as well as the ease identification circulating tumor cells (CTCs) for, in addition to improved cancer diagnostics, also the prediction of patient re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The Transnational Divide: Local Triggers, Social Networks, and Group Identities'.

assistant: **Concept**

TRANSNATIONAL seeks to explain a surprising and consequential feature of contemporary democratic politicsthe intensity of polarization on immigration, Europe, and climate change. While recent research has made impressive advances in understanding individual attitudes and party-political competition, there is currently no empirically verified theory of how a persons social context shapes their response to issues that arise on the political agenda. Without such a framework we cannot understand the rising incidence of group solidarity and affective polarization in our societies. TRANSNATIONAL combines insights from the literatures concerned with networks and identity formation to theorize the social contexts in which people respond to major events. This approach provides a micro-social foundation for Lipset & Rokkans classic cleavage analysis and offers the prospect of a unified theory of political conflict. TRANSNATIONAL gains inferential leverage in the face of causal complexity by linking national surveys, natural experiments, and semi-structured interviews in three modules. The first module provides a comparative frame by conducting a cross-sectional survey of political attitudes, identities, and digital and face-to-face networks on the transnational divide in six countries. Modules 2 and 3 drill down by devising natural experiments that allow deep investigation of how local populations respond to a specific situational trigger. These are a) spatial proximity to refugee housing; b) the variable effect on UK localities of exit from the EU; c) new climate impact scores that differentially affect rural and urban localities.


**Keywords:** political parties, multi-level governance, European integration, radical right parties, globalization, political conflict, immigration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Social Aid Interactive Developments' (SAID) under Fifth Framework.

assistant: **Objectives**

SAID is meant to develop a set of telematic services for the elderly to aid the work of Social Assistants by means of Digital TV infrastructure, intelligent Software Agents and Mobile phone information services. The objectives are not only to provide basic social services as they are conceived today, but also to extend the ambit of social support to the new demands appearing in the 21st century in two areas: provision of basic care services remotely and making possible access to the IST for the elderly. The first objective is accomplished by means of an open platform based on Digital TV, where a configurable number of services can be provided depending on the specific needs: videoconferencing, surveillance, alarms, entertainment, household services, etc. The second one will do extensive use of Autonomous Agents technology to implement personalised assistants able to act as information provider, reminder, shopping assistant, etc.Objectives:The objective of SAID is to develop an innovative Social Assistance infrastructure for: more efficient social care for the elderly, improved services and the possibility to get access to the IST for a sector of the population that has been absent up to now. SAID has two faces: for the elderly it will implement a mixed computer / personal based environment where he will be given the opportunity of self care while he has the possibility of 24h aid when needed. For the Social Assistant it will mean a complete set of tools that allow him focus efforts on the most needed problems that result in more efficient work in terms of time and cost. SAID will support the following services under the DVB-MHP digital TV platform: Video Conferencing, alarms, surveillance, personalised assistants (shopping, reminder, info. searcher), household, entertai