RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Revolutionary vascular repair patch to treat aortic dissections' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Aortic Dissection is a major disease affecting 3-12/100.000 patients/year. Global mortality rates are upto 40% and yet symptoms are hard to diagnose, with today´s treatments not specifically designed for the condition resulting in a high tendency to fail.Aortyx wants to change that. We have developed a Vascular graft, a “patch” that is inserted via a minimally invasive procedure. It adheres to the fissure, stops the blood flowing between the layers, then promotes natural repair. Complicated, life threatening, Open Heart Surgery is avoided, as well as post-operation failures as we replace today´s rigid ‘stents’ with our highly flexible, almost natural patch.We have successfully proved the product operation in early pre-clinical trials, have a patent application in progress and the backing of several expert vascular surgeons.For this phase 1 project we wish to finalise our pre-clinical trial planning, as well as our business planning to create a new vascular grafting company with predicted accumulated incomes of 13.78M€ and 13 employees by 2025.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Self-assembly of magnetic core-shell nanoparticles at liquid-liquid interfaces for the fabrication of ultra-thin responsive membranes' to be submitted under Seventh Framework.

assistant: **Abstract**

The goal of this project is to study and control the self-assembly of superparamagnetic iron oxide nanoparticles (NPs) stabilized by a shell of responsive polymers at liquid-liquid interfaces in order to crosslink them into ultra-thin, mechanically stable, responsive membranes. This novel “smart” material will have unique properties suitable for applications in miniaturized lab-on-chip and other microfluidics devices. The interdisciplinary nature of the project contributes to its scientific novelty and impact, and constitutes an extraordinary training experience for the applicant. In the first part of the project, the applicant will develop a novel combination of experimental techniques to characterize the fundamental aspects of core-shell NP adsorption at liquid-liquid interfaces. By means of advanced confocal microscopy and particle tracking, complemented by pendant-drop tensiometry, this project will yield an exhaustive characterization, both from a microscopic and macroscopic point of view, of such system, so far practically unexplored. The obtained understanding - of high scientific relevance in its own right - will be used to optimize the design and fabrication of crosslinked responsive NP monolayer membranes. Using superparamagnetic NPs stabilized by a shell of crosslinkable thermoresponsive polymers, the applicant will produce ultra-thin robust assemblies which can respond reversibly to external stimuli. Temperature changes and consequent responses can be imparted to the system locally by exploiting the magnetic functionality of the NP constituents (heat transfer in an AC magnetic field). Moreover the crosslinked membranes can be actuated in DC magnetic fields as envisaged for applications. The responsive properties of the resulting materials, which have no curr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A longitudinal assessment of treatment experience, symptoms and potential associations with biomarkers in cancer patients undergoing immune checkpoint inhibitor therapy' (PaSION).

assistant: **Concept**

Immuno-oncology (IO) and specifically immune checkpoint inhibitors (ICIs) have recently shown significant clinical benefit in a growing number of different tumor types. However 60-90% of the patients experience immune-related adverse events (irAEs) associated with inflammatory or autoimmune responses that can affect any organ and system. Early recognition and treatment of these irAEs is crucial to reduce morbidity, organ complications and ultimately, mortality. Patient reported outcomes (PROs) result in earlier detection of symptom occurrence and severity compared to clinician reports, which tend to understate these experiences, and can serve as a reliable complementary indicator for AEs before their clinical manifestation. Although the use of PROs is highly recommended to be included as an endpoint in clinical trials, no IO-specific-PRO tool has been developed to date and the use of general cancer-specific instruments does not address the needs, concerns and specific symptoms experienced by patients undergoing ICI therapy. The overall objective of this project is therefore to gain a comprehensive understanding of patients’ experience over the immunotherapeutic treatment course based on qualitative interviews with patients, their caregivers and healthcare professionals. This will enable evaluating the need for adaptation or development of new IO-PRO measures. Furthermore, variations in immune-related biomarkers might predict the appearance and severity of symptoms and serve as surrogates for high-grade AEs risk stratification. Hence, this project will additionally investigate potential associations between symptoms and biomarkers over the treatment course in order to elucidate existing correlations. Results derived from this study will facilitate the development of more
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Charting the landscape of brain development by large-scale single-cell transcriptomics and phylogenetic lineage reconstruction'.

assistant: **Innovation**

Embryogenesis is the temporal unfolding of cellular processes: proliferation, migration, differentiation, morphogenesis, apoptosis and functional specialization. These processes are well understood in specific tissues, and for specific cell types. Nevertheless, our systematic knowledge of the types of cells present in the developing and adult animal, and about their functional and lineage relationships, is limited. For example, there is no consensus on the number of cell types, and many important stem cells and progenitors remain to be discovered. Similarly, the lineage relationships between specific cell types are often poorly characterized. This is particularly true for the mammalian nervous system. We have developed (1) a reliable high-throghput method for sequencing all transcripts in 96 single cells at a time; and (2) a system for high-throughput phylogenetic lineage reconstruction. We now propose to characterize embryogenesis using a shotgun approach borrowed from genomics. Tissues will be dissected from multiple stages and dissociated to single cells. A total of 10,000 cells will be analyzed by RNA sequencing, revealing their functional cell type, their lineage relationships, and their current state (e.g. cell cycle phase). The novel approach proposed here will bring the powerful strategies pioneered in genomics into the field of developmental biology, including automation, digitization, and the random shotgun method.  The data thus obtained will bring clarity to the concept of ‘cell type’; will provide a first catalog of mouse brain cell types with deep functional annotation; will provide markers for every cell type, including stem cells; and will serve as a basis for future comparative work, especially with human embryos.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enhanced Durability Resurfacing Endoprosthesis' under Seventh Framework.

assistant: **Concept**

Each year in Europe there are:- • 800000 hip operations costing approximately €1,942 per/implant, worth over €1.5 billion • Hip implant operations are rising by approximately 15%. • Currently 10% of all the prosthesis implanted are in patients under 55 years of age of which 33% of these will fail within 16 years with a further 20% of implant fitted to over 55’s failing with in 20 years requiring revisional surgery costing €2.3 billion per annum. Treatment of younger patients with severe hip disease using a conventional THR presents a challenge with the rate of success being very low, (most failing within 16 years). To over come this Finsbury help develop the MoM BHR resurfacing hip with a survival rate of 93% over a conventional THR. However, studies have reported high concentrations of Co & Cr in the serum and/or urine of patients with MoM resurfacing implants. Studies have shown that increased levels of Co & Cr cause caners such as leukaemia and are linked with myocardiopathy. During the course of this project we intend to overcome these problems by developing a ceramic one ceramic or ceramic on polymer resurfacing hip. Like that of the MOM prosthesis will only cover the femoral head thus retaining all of the desirable properties associated with retaining an intact femur.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An investigation into the production of tools by electrochemical means from sterolithographic models' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Foreseen ResultsSuccessful completion of the project will result in increasing the competitiveness of the European toolmaking industry substantially. in the UK alone the toolmaking market has a size in excess on one BILLION ECU annually. Recent studies have shown that successful implementation of this technology could save at least 20% of the costs involved in this market.All parties have been chosen for their excellence in the fields required to complete this project successfully. Progress reports will be circulated regularly by all parties to all parties involved. Bi-annual meetings will be held to assess the development of the programme, and to ensure appropriate progress is made. The interaction of all the parties is considered to be highly important, and the steering committee will ensure that this occurs.All results will be published at the end of the project and made available to all parties.During recent years, the technology of Rapid Prototyping has had a significant impact on design techniques. In particular it has had a very significant impact on the times and costs required to develop new products to the pre-production stage. A number of measures show that the technology has grown exponentially during the last 6 years.The most common Rapid Prototyping techniques is one named sterolithography. It has been developed primarily by the 3D Systems corporation based in California. The Buckinghamshire College is fortunate in being one of the few Institutes of Higher Education in Europe which possesses one of these machines, and in fact operates the only 3D Systems Sterolithography Machines, SLA 190 in Europe.Whilst Rapid Prototyping of models of production parts is very useful, its development has catalyzed the desires from industry for a techniques which can also q
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Disruptive innovation in healthcare requires disruptive innovation in medical ethics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Several recent medical innovations do not conform with the way medicine traditionally operates, but rather blur the boundaries of medicine and/or side-line the doctor-patient relationship as an essential aspect of healthcare. Examples of this are healthcare apps, direct-to-consumer genetic testing, disease surveillance, electronic patient records, telehealth and  certain types of clinical decision support systems. I postulate that several of these new innovations will fundamentally change the very concept of medicine and thus turn out to be disruptive innovations. Given that medical ethics are tailored to ‘traditional’ medicine, we should be critical about its current ability to cope with these changes and question whether the discipline of medical ethics is sufficiently equipped to guide new, disruptive innovations in healthcare towards their great potential in terms of improving patients’ access to good quality healthcare, while also safeguarding patients/users for the risks that come with them, not only in terms of health, but also in terms of infractions against firmly rooted values such as patient autonomy, the duty of care, confidentiality or privacy. If the medical ethics toolbox is ill-equipped to deal with these challenges, we urgently need to rethink or replace procedures, principles or theories in order to remedy this problem. DIME will address these challenges by focusing on three main objectives:(1) To establish where the most prominent ethical disruptions are located and therefore in which areas re-orientations of ethical principles are most urgently needed.(2) To develop normative arguments regarding which fundamental procedures, principles or theories in medical ethics ought to be reinforced, adapted or replaced in the face of disruptive innovations to b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hardware-assisted Adaptive Cross-Layer Security for Computing Systems' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Today's computing systems are facing an unprecedented security threat posed by recent attacks that use software to exploit hardware vulnerabilities, as shown by attacks like Spectre, Meltdown, Foreshadow, and follow-ups - affecting a wide range of computing platforms and manufacturers, including Intel, AMD, and ARM. These cross-layer attacks reach far beyond exploiting microarchitectural vulnerabilities and allow unprivileged software to exploit a variety of hardware design and implementation flaws, as we demonstrated in the world's largest System-on-Chip (SoC) security competition that we have been conducting with Intel since 2018. This adversarial paradigm shift sidesteps decades of security research that assumed a layered architecture where hardware is flawless and trustworthy. Existing solutions, such as software patching or specific hardware changes are ad-hoc, expensive, or only mitigate specific known attacks. Particularly, patching hardware after fabrication is very limited or impossible.This proposal, HYDRANOS, envisions hardware-assisted adaptive security, a radically different approach to enable flexible security for future computing systems. We aim to design, prototype, and evaluate dedicated configurable hardware inside the SoC design to enable post-fabrication reconfiguration of key security-relevant hardware primitives to mitigate new attack vectors. Moreover, we provide an evaluation framework that includes novel hardware fuzzing techniques to significantly improve existing hardware-vulnerability detection methods at design time.HYDRANOS is a game changer for trustworthy computing, allows to fundamentally and flexibly tackle todays and future cross-layer attacks on security-critical systems, and provides novel research to pave the way towards future-proo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'HealthBread product innovation based on FP6 HealthGrain results and knowledge' (HealthBread), addressing dissemination and exploitation.

assistant: **Impact**

The HealthBread project (HealthBread product innovation based on FP6 HEALTHGRAIN results and knowledge) will, based on an SME and consumer oriented approach, develop whole grain and white breads with further improved nutritional and product quality by applying scientific and technological knowledge from the EU FP6 HEALTHGRAIN project into production and marketing of commercially viable, healthier bread. The HealthBread Manual, with guidelines for choice of raw materials, processing and nutritional statements, in the languages of the participating SMEs bakeries will translate the scientific knowledge into practice and enable them to produce improved bread.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Banking Market Structure and Firms Financing in Financial Turmoil”' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The proposal aims to investigate the existing relationship between banking market structures (e.g. banks’ headquarter location, efficiency and banks board of directors ) and the supply of credit to non-financial firms  by looking and comparing German, French and Italian banking systems during financial turmoil. In particular, I disentangle the effects of specific characteristics of financial markets at local market level, distinguishing the factors that may have driven differences in the severity of credit constrain to different types of firms on their economic performances. One of the most debated consequences of the crisis has been the possible credit crunch caused by the contraction of the bank’s capital and the adverse liquidity shock in interbank market. Motivated by theoretical and empirical evidences at country level, whether and how financial structure influences firms’ financing and consequently their profitability remain a crucial policy issue. Despite the debate on-course the analysis of some mechanisms through which financial structures affect firms’ financing and their profitability has been left under-researched particularly in a cross-country comparing view, at local market level and after the collapse of Lehman Brothers. There are theoretical suggesting that the market structures of the banking systems have a non-trivial impact on the process of capital accumulation. Any departure from perfect competition in the credit market, driven by factors both imputable at the structure rather than at bank level,  introduces inefficiencies that would harms' access to credit, thus impacting negatively on firms’ performance. The findings could identify the mechanism and possible effects as well as differences of the local market structures in the severity of credit c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Social movements and mobilisation typologies in the arab spring' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The present proposal aims to revitalize and to reinforce the Europe-Arab World exchange in the field of research and training in Social Sciences, during a peculiar historical moment, characterized by the socio-political changes that have taken place in the last year in the Southern Mediterranean Arabic societies. Paying attention to the new context, the proposal will especially focus research on social and political movements in the frame of change dynamics and applying a comparative approach, taking particularly into account the experience of Eastern European countries. The proposal objectives are to contribute to the enrichment of the analytical interpretation and to the monitoring of the social, political ans cultural processes that have taken and are taking place in the arabic World, through the collection of new empirical materials and the development of innovative analytical tools from different disciplines (political science, sociology, anthropology, cultural studies, religious studies, media) in an interdisciplinary and comparative approach. These tools will be developped through the active participation of early researchers in the implementation of the proposal, articulating fields surveys and conceptual appoach: structuring exchanges  through  interdisciplinary training sessions to be followed by  mixed groups of junior researchers from the Arab and European  universities;  implementing a joint doctoral program; organizing conferences, workshops and managerial meetings in different universities of Europe and Maghreb.Consequently, the outcomes of the proposal will contribute to the ongoing international academic and political debate on social and political change to reach a best governance. It will also contribute to bring fresh knowledge in the study of concep