RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Securing the spices and herbs commodity chains in Europe against deliberate, accidental or natural biological and chemical contamination' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Securing the food chains from primary production to consumer ready food against major deliberate, accidental or natural CBRN contaminations stands in close context with the safety of food products. SPICED objectives are to characterize the heterogeneous matrices of spices and herbs and their respective intra- as well as interplant production and supply chains in context with relevant biological and chemical hazards that can lead to major deliberate, accidental or natural contaminations in the food supply chain, to improve the knowledge about biological hazards properties and on-site and high throughput diagnostic methods for appropriate detection, to reduce (industrial) chemical adulterations and to ensure authenticity of spices and herbs by evaluation and improvement of non-targeted fingerprinting methods, and to improve alerting, reporting and decontamination systems as well as techniques to ensure prevention and response on high quality level. The consortium will evaluate the most important spices and herbs that can cause or be used for natural, accidental or deliberate contaminations, depending on e.g. the amount produced, consumed and frequency of natural or accidental contaminations. SPICED will focus on pathogen agents based on e.g. frequency of natural occurrence, possible impact on human health, and relevance for food terrorism. SPICED has been planned for 36 months and brings together experts and scientists from 11 different partners. The spice and herbs primary production and supply chain is very heterogeneous since most of the condiments are imported from non-European countries. The consortium of SPICED reflects the major players of the European spice market from major importer (Germany) over major re-exporter (Netherlands) to the main European paprika produ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Black phosphorus interlayer coupling in heterostructures with boron nitride for photonics' (BrightPhoton), addressing dissemination and exploitation.

assistant: **Impact**

Black Phosphorus or P(Black) is a lamellar crystal of tervalent P atoms stacked by weak Van der Waals interactions that can be exfoliated down to the monolayer. Recent results demonstrate that quantum confinement in P(Black) thin layers leads to promising electronic properties such as an extremely high carrier mobility and tunable direct band gaps from visible to mid-infrared depending on the layer thickness. These properties have significant echoes in photonics and 2D transport physics. Studying pristine P(black) thin layers is however challenging due to the poor chemical and structural stability of elemental phosphorus. Indeed, the PI and his coworkers recently revealed a photo-activated charge transfer process involving adsorbed oxygen and water in ambient conditions that leads to a strong photo-oxidation of P(Black). Our approach targets 1- the fabrication of nano-heterostructures based on P(Black) thin layers sandwiched and or intercalated with protective Boron Nitride (BN) insulator layers ; 2- the fundamental studies of this new type of material. The scientific program focuses on the band gap study of P(black) depending on the thickness by Transmission Electron microscopy (TEM) and on electroluminescence of P(black) based heterostructures.The project represents a major leverage in the career trajectory of the PI by a fast, efficient and sustainable repatriation of this new field of research in the French and European landscape, in complete synergy with the momentum given by the EU member states on 2D related materials. Moreover this action offers, via a strong and customized training programm, a unique opportunity to the PI to acquire new and complementary skills in Boron Nitride thin layer synthesis and TEM, especially the TEM-Energy Electron Loss Spectroscopy (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From river catchement areas to the sea : a comparative and integrated approach to the ecology of mediterranean coastal zones for sustainable management' (MED-CORE).

assistant: **Concept**

Target systems are sand beaches and their ecosystems. The research will extend to adjacent systems influencing and/or being influenced by the defined system, contributing to coastal equilibrium. The project aims at: definition of guidelines and ecological criteria for preservation of environmental quality through the identification of functional links between elements of coastal ecosystems and influencing zones in the Mediterranean; development of early warning indicators of degradation and long-term indicators of sustainability of coastal ecosystems; preparation of a manual regarding the application of ecological indicators of coastal quality, to be used by environmental managers and decision-makers . A transdisciplinary characterisation will be conducted at chosen sites, which share common problems of the Region, and the analysis of the property of different ecological indicators, from landscape to species and genetic levels, will be made.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Uncovering the Mechanisms Behind Adaptive Gene Expression Switching in Malaria Parasites' (MALSWITCH) under Horizon 2020.

assistant: **Objectives**

The malaria-causing parasite Plasmodium falciparum has evolved a strategy of clonally variant gene expression to control essential biological processes like antigenic variation and sexual commitment during its persistent blood-stage infection of the human host. Heritable epigenetic silencing of the underlying specialized gene families ensures the limited expression of only a subset of these genes at any time. Switching the expression of individual clonally variant genes enables the parasite to rapidly adapt to changes in its environment, evade the immune system and switch its cell cycle to the development of mosquito-transmissible gametocyte stages. Expression switching of these clonally variant genes therefore represents a key strategy for parasite survival and underlies the evolutionary success of this deadly pathogen. Despite decades of research, the molecular mechanisms coordinating this adaptive gene expression switching are not understood. In my recent research, I developed a unique experimental tool, which for the first time allows the conditional expression switching of endogenous genes in the parasite. I will combine this system with novel CRISPR/Cas derived methodology and proximity-based labelling approaches to deliver the first systematic identification and characterization of the molecular mechanisms controlling epigenetic gene expression switching. The experiments outlined in the proposal will reveal the core of the molecular machinery underlying this fundamental process and elucidate regulatory mechanisms that allow the parasite to translate environmental signals into adaptive switching of clonally variant genes. This will transform our understanding of the molecular mechanisms driving adaptation of this deadly parasite and in the long run might contribut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Comparative Visual Analytic techniques for Relational Information Visualisation' under Sixth Framework.

assistant: **Concept**

The basic hypothesis of this project is that relational information visualisation approaches, embodied in graph drawing techniques for the exploration and navigation of large graphs are not sufficient and that a hybrid approach which incorporates multiple views of the data should be taken. The scale and complexity of the relational data sets that people in domains such as biochemical engineering, software development and financial modelling are attempting to study, understand and reason about has motivated t his work. Societies continued reliance on information and communications technologies has resulted in organizations generating, gathering, and storing raw data" at a rate growing by 120% every year. Recent research suggests that the human race has created about 1 exabyte (1018) of data to date and that the next exabyte of data could be generated within the coming 3 years.The ability for even a mid-sized organization to store tens to hundreds of terabytes of data is within reach. Massive storage technologies are rapidly outstripping our ability to effectively analyse, explore, and understand such voluminous data. Our aims in this project include, the exploration of hierarchical compound graphs suitable for visualisation and exploration on different levels of abstraction and across different viewing paradigms, exploration of different space decomposition techniques suitable for our widely cited FADE paradigm, the study of fast approximate force directed layout algorithms in comparison with structure and city-plot layout techniques, the extension of our visual pr's abstraction technique from the node-link visualisation to both structure and city-plot views and an in-situ experimentation with our hybrid visualisation approach in a real world software engineering environ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modeling Common Ground' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Language is inherently ambiguous. The meaning of words and sentences depends on the identity of the communicative partners and the nature of the context. In simple behavioral experiments children and adults can use a wide variety of social-contextual cues (jointly known as “common ground”) to interpret ambiguous utterances. But this limited empirical evidence – especially in the developmental context – does not live up to the theoretical importance of common ground: In theory, common ground is not only involved in online language use but it is also a necessary prerequisite to learn language in the first place. Studying the development of children’s ability to form and use common ground is therefore crucial to understand the psychological foundation of language. It is still unknown how both adults and children integrate different social-contextual cues in complex, naturalistic interactions. Bayesian modeling provides a mathematical framework for formalizing theoretical assumptions about this interaction and deriving quantitative predictions about new experimental situations.This project will unite developmental and computational approaches. The key objective is to find out what constitutes common ground at different ages and how it informs language learning across development. I will develop mathematical models and behavioral experiments in parallel to obtain quantitative predictions for different forms of interactions between social-contextual cues. By comparing these predictions to data from early children’s word learning at different stages of development, I will be able to empirically evaluate the theoretical importance of the different components of common ground. The interdisciplinary focus of the project at the intersection of psychology, linguistics and computer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Automated fish ageing' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Most of European fish stocks are assessed using age-based models, and the cost of the acquisition of age data from otolith readings raises several million euros annually. Low uncertainty in age estimation is however reached for only 25% of fish stocks under ICES advising process. The impact of ageing errors on stock assessment is obvious though obscure. In this context, automated ageing systems would provide a mean to standardize ageing among laboratories and to control ageing consistency while reducing the cost of the acquisition of age data. No such system is currently available, although preliminary results provide the basis for such developments. This two-year project aims at developing fully automated and robust systems for routine ageing. It will comprise four workpackages in addition to project management (WP0): the collation of the otolith material and the creation of bases of annotated otolith images (WP1), the development of algorithms for fish ageing automation from otolith features (WP2), the implementation these automated ageing modules in a software platform dedicated to otolith imaging (WP3), the cost-benefit analysis of the proposed automated ageing systems (WP4). The whole processing chain from the acquisition of otolith data to the actual ageing issue using pattern recognition or statistical inference will be coped with. The demonstration component will include the demonstration of the degree of automation of the proposed systems and a cost-benefit analysis of these automated solutions for three case studies: cod from Faeroes, North Sea and North East Artic, plaice from the Eastern English Channel (VIId) and Iceland, and anchovy from the Bay of Biscay. The focus will be on demonstrating the consistency of automated age estimation with respect to the ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Interpreting the SHH signal: real-time monitoring of the dynamic regulation of GLI3' to be submitted under Seventh Framework.

assistant: **Abstract**

The SHH morphogenetic pathway exerts multiple functions during embryonic and adult life. It is involved in various cellular contexts to provide positional information, but also controls cell survival, proliferation and differentiation. Aberrant activation of the pathway has also been linked to tumour formation and growth. The SHH signal is integrated by receiving cells via the GLI transcription factors, which regulate the expression of SHH target genes. In particular, the GLI3 protein is processed into a repressor (GLI3R) form in the absence of SHH, while is converted into a transcriptional activator (GLI3A) upon exposure to SHH. SHH being a secreted factor, it is thought to establish a dual GLI3R:GLI3A gradient, with high levels of the GLI3R away from the source and high GLI3A close to the SHH-expressing cells. This mechanism permits various levels of activation of the pathway, depending on the GLI3R:GLI3A ratio. Despite the initial description of many pathway target genes, the primary response to variable SHH doses over time, and the subsequent alterations in GLI3R:GLI3A isoform ratios, are poorly understood. We have manipulated the Gli3 locus in mouse ES cells by RMCE to introduce a FLAG-tag into the endogenous protein. We have evidence that this FLAG-tagged GLI3 creates a sensor of the SHH signal (GLI3A-FLAG). We will use neuralized embryoid bodies and the knock-in mouse line derived from GLI3A-FLAG ES cells to monitor the cellular and molecular dynamics of GLI3A in sensing SHH activity. This system will permit us to track the relative occupancy of the promoter/regulatory elements of SHH target genes by GLI3, allowing a real-time readout of the way cells respond to SHH over time. Moreover, we will be able to visualize and study the postulated Gli3A gradient in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Review of externalities data - red' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The final objective of the proposed project is to evaluate the state of science on externalities research and the level of knowledge achieved so far on the general issue of external costs, based on an extensive search and review of literature and documentation in Europe and in other parts of the world. These studies will highlight the way that external costs analysis has been used, the way that uncertainties have been dealt with, and differing views on valuation. A major outcome of the project will be a database containing externalities data drawn from all relevant sources identified and analysed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural and functional genomics tools for cattle research' to be submitted under Fifth Framework.

assistant: **Abstract**

The objective of the proposed work is to develop advanced genomic tools that will help researchers to identify the genes involved in important traits in cattle, starting either from their map position, or from examining expression profiles. A set of 20,000 non-redundant cDNAs will be sequenced. These cDNAS will be used to construct macro-and micro-arrays, which can be used to examine gene expression under various physiological conditions. The sequence information will also be used to construct a high-density gene map" of the bovine genome and hence high-resolution comparative genome maps with man and mouse. The latter will aid the identification of postional candidate genes for mapped traits. The sequence information and RH maps will also be used to in collaboration with an international project to construct a scaffold physical (BAC) map of the entire bovine genome, which will be as entry for targeted DNA sequencing."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Patterns of land-use and human mobility in a time of climate changes (Italy, 6th to 10th cc.)' (InAndAround).

assistant: **Concept**

The period from the sixth- to eleventh- century in Italy is one of the most profound political and social laboratories in European history. Centered on this region and period, the primary goal of the In&Around project is to chart the effects of climate change on human behaviour. By focusing on early and high medieval Italy, the project aims at exploring the interaction between climate variability and human agency with a lens towards management of the environment and in the light of shifting political regimes, while capturing details on past issues of contemporary significance like human mobility and workforce relocation.  Within the area of Italy, two micro-regions with distinct medieval histories are targeted for specific investigation: Lucca and Rieti.  The project will generate new long-duration and high-resolution climate records from recently cored lake sediments combined with data derived from written sources and already extant climate reconstructions. By way of its innovation-through-interdisciplinary approach, the project will offer important opportunities for expanding the applicant’s expertise through integrating different kind of datasets, while contributing enormously to an expanding field of study in i) determining how data drawn from historical archives, natural proxies and modelling may inform respectively one another; ii) filling in a gap in research both chronologically (the first millennium of the Common Era) and geographically (the Italian peninsula) and iii) producing two new research tools useful for future studies, i.e. a repertory of 'reclaimed lands' and climatic extremes and a statistical model for climate reconstructions. Through its foci on the human responses to climate and environmental change, the project responds directly to the Horizon 20