RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Graphene nanoribbon based chemical sensors' (GNRSENSE).

assistant: **Concept**

Significant progress and novel discoveries have been made in the past two decades in the science of nanometer scale carbon based materials. Novel physical phenomena characterizing low dimensional systems have been discovered leading to the development of prototype devices. Graphene nanoribbons have very recently emerged at the front of this field due to their unique electronic, magnetic and mechanical properties and the ability to fabricate them in a controllable and reproducible manner. Despite the considerable progress that has been made in the controlled fabrication and the understanding of the physical properties of graphene nanoribbons, currently, much less is known regarding their chemical nature. The large surface to volume ratio and the existence of reactive edges are expected to considerably enhance their chemical reactivity with respect to related systems such as carbon nanotubes and infinite graphene surfaces. Thus, understanding the surface and edge chemistry of graphene nanoribbons and utilizing it for chemical sensing purposes is a major challenge. It is the purpose of this research program to address this challenge. To this end, our proposed program will focus on the development and implementation of a new model that will allow the accurate treatment of the electronic and transport properties of finite extended systems such as graphene nanoribbon surfaces. Using this model we will study in depth the process of molecular adsorption on the surface and edges of nanoribbons and its influence on the electronic properties of the ribbon. Furthermore, we propose to study new schemes to control the reactivity of the ribbon and the selectivity of the adsorption process. We believe that the proposed research program will enhance the understanding of the chemical nat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reliable multidetection sensor for advanced control in latex production' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Paper and textile industries are using increasing volumes of waterborne polymer emulsion, especially styrene/butadiene copolymers, as binders in coated paper and carpet manufacturing. As the market is being drawn to cost effective products with improved environmental performance, latex producers are facing stringent requirements to provide polymer emulsion with lower organic residuals (monomer & by products) so as to neutralize the taste and odor of the final end products. The strong competition among latex producers, especially from non European companies, makes it urgent to decrease the time to market while lowering the costs, minimizing the environmental harm and increasing safety and productivity. The proposal is aimed at developing a new polymerization process and on line reaction monitoring that will efficiently limit the latex contaminants at the source, rationalize the plant operation of existing facilities, and shorten new product development time. It will consist of a new multidetector sensor to monitor polymer reaction in real time, integrated in an adaptive process control system with actuators (REMAP).The main innovations are based on remote sensing through opdc fibers, high signal accuracy and ease of use (no sampling loops). REMAP should make it possible to track pre defined reaction kinetics with unprecedented accuracy on the industrial level. These reaction pathways will be optimized through an overall kinetic model developed within the framework of the project. The main milestones and deliverables of the project are:  Construction of the sensor prototypes operating at laboratory and pilot scale  Modelling of the reaction kinetics and design of process control strategies  Definition of S/B emulsion polymers targeted to market specifications  Implementat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The creation of European management practice'.

assistant: **Innovation**

The technology of managing large organisations has become an important feature of modern societies. Although this technology is associated with a considerable degree of uncertainty, a great many management tools and models are used in society at large, as well as in individual organisations, both private and public. This management technology is to a great extent the product of scholars and practitioners in the United States, but it is used extensively even in systems which differ in many ways from the North American. This is particularly remarkable since modern organisation theory has provided firm evidence that the organisational context is crucial to the efficient use of different organisational tools. Thus even if they are efficient in the North American context where they have been developedand this is far from certain - it is highly doubtful whether they will be so in another context. Constraints which can be expected to affect the success of management models include legal systems, financial systems, systems for corporate governance, industrial structures, cultural traditions, etc. Needless to say these conditions differ as between the United States and other countries. From a EU perspective there is thus an urgent need to explore in some detail the diffusion of North American models in the European context. The present research programme will consequently focus on two questions: 1. To what extent has modern management technology been diffused in various European countries?, 2. What message has been communicated through this diffusion process? From a consideration of two questions it can be established that management technology is diffused by three major carriers: graduates, publications and consultants. In the case of all three of these carriers the task of thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Effects of atorvastatin on vascular and myocardial redox state and inflammatory mechanisms in patients with ischemic heart disease' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Ischemic heart disease (IHD) is characterised by increased systemic oxidative stress status. Free radicals activate redox sensitive pathways responsible for the production of inflammatory mediators with key role in IHD. Statins have a beneficial role in coronary atherosclerosis, but their potential effect on key features in the pathophysiology of IHD is unclear. In this context, statins may have a beneficial effect in IHD by modifying myocardial and vascular redox signalling. In part A of the study, we will obtain segments of internal mammary arteries (IMA) and saphenous veins (SV) from 60 patients with ischemic heart disease (IHD) undergoing coronary bypass operation. In these vessels we will evaluate the direct effect of atorvastatin on the main sources of superoxide (O2-) radicals generation (uncoupled nitric oxide synthase (NOS) and NADPH-oxidase), by using an ex-vivo setup. We will also investigate the direct effect of atorvastatin on the expression of adipokines (cytokines with important paracrine/endocrine role in IHD) in different types of adipose tissue. We will also examine the individual effect of each adipokine on vascular redox state and signalling. In part B of the study, 60 patients with IHD will be randomised to receive atorvastatin 40mg/d (n=30) or placebo (n=30) for 7 days before their bypass operation. The effect of atorvastatin treatment on endothelial function will be examined by ultrasound in the brachial artery. The effect of atorvastatin on redox signalling (O2- and ONOO- radicals) and inflammatory pathways in myocardium, vascular wall, and human adipose tissue will also be evaluated. This will be the first study examining the effects of atorvastatin on redox state and the activation of redox-sensitive pathways in vascular wall and myocardium of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Safe personal transportation that makes you healthier.' (2014-2020).

assistant: **Concept**

The “last mile” between hubs and homes, as well as short distance transport needs for persons with walking limitations, are urban mobility challenges that we address at Torqway Company Ltd with a new way to move. Our manual-powered four-wheel platform vehicle introduces “Nordic Driving”, driven by arm movement on levers with an innovative gear system (under patent in 9 countries) which converts every movement into forward motion up to twice the speed of normal walking. Based on this core technology, Torqway Hybrid offers additional electric motor assistance like an e-bike for senior users and persons with reduced lower body mobility. Medical studies on Torqway confirm that the arm movements while standing induce isometric muscle contractions shown to improve upper and lower body strength, coordination and weight control.This innovative outdoor vehicle consistent with the Transport and Smart Cities framework and the Electric Mobility Europe initiative can be used in several ways: as an active mobility and transportation device, as an outdoor gym joining several exercises in one and as a tool for light physical rehabilitation. Aside from individual purchasers, sales target sport and physiotherapy centres, tourism and leisure mobility. As confirmed by our Phase 1 Feasibility Study, Torqway Hybrid end users are 55+ y.o. early adopters of both sexes with purchasing power in EU member states with established bicycle use and infrastructure, starting with Germany, Netherlands, Nordic coutries, Poland and USA. Markets are segmented into growth sectors that reflect increasing expenditure by an aging, health-conscious population: Fitness equipment (global market worth 10.38 bn USD), Personal mobility (worth 6.65 bn USD), Home physical rehabilitation (worth  2.86 bn USD) and Physio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Flexible and modular large battery systems for safe on-board integration and operation of electric power, demonstrated in multiple type of ships'.

assistant: **Innovation**

FLEXSHIP will facilitate the transition of the waterborne sector towards climate neutrality by delivering a digital green concept for electrification of vessels consisting of a Green Digital Twin (GDT) for designing fit-for-purpose vessel electrical grid architectures and integrating a large battery capacity system into two existing vessel (DEMO 1 & 2) electrical systems, a compact, low-weight, modular and simple, high-efficiency battery system, and a safe integration guide of the system onboard ensuring system interoperabilityThe overall goal of FLEXSHIP is to develop and validate safe and reliable, flexible, modular, and scalable solutions for electrification of the waterborne sector. This includes the reliable design and development of modular battery packs; safe on-board integration including the battery system and its associated electrical distribution grid into the vessel’s existing power grid; optimal design of energy management system (EMS) to maximise the operational flexibility and energy efficiency (both full-electric and hybrid), and smart control for improved lifetime of the battery system and critical power components.The objectives will be achieved by 8 WP and 16 partners within 48 months. In WP1 identification of specification and mapping of requirements will be done. In WP2 the vessel electrical architecture will be designed and optimised by means of the Green Digital Twin. In WP3 the development and optimisation of individual components and sub-systems will be done and the testing of the system at component/sub-system level will consist of hardware-in-the-loop (HiL) and software in the loop (SiL) tests in WP4. The full FLEXSHIP system will be tested in two demonstrations in WP5 with minimum 150nm sailing distance and in WP6 contributing to 300nm by gre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Algorithms and Game Comonads' in the context of a Horizon Europe call.

assistant: **Objectives**

Our modern society is driven by computers, digital services, and algorithms. Understanding their weaknesses and limitations is one of the main subjects of study of theoretical computer science. Probably the most studied aspect of algorithms is their efficiency of use of computational resources, embodied as the running time of an algorithm. Parameterised complexity is a branch of theoretical computer science interested in determining whether there exists an efficient algorithm that solves a given computational problem. The efficiency is determined based on the structure of the input data.The main limitation of parameterised complexity is that these analyses of computational problems are done on a case-by-case basis. This means that if somebody changes the problem or its parameterisation ever so slightly, the whole analysis has to be redone from scratch.To tackle this problem we propose to use game comonads, a novel structural approach to logic in computer science. The theory of game comonads draws its strength from category theory, a well-established discipline of mathematics which specialises on compositionality, reusability of its tools and high-level of abstraction. Game comonads, despite being relatively new, have already shown to be a useful tool in the study of finite model theory, which is an adjacent area of study of parameterised complexity.The primary goal of this project is to bring compositional tools of category theory into the setting of algorithms, with game comonads acting as the connecting glue. This project bring together expertise in category theory, in the form of the applicant and expertise in parameterised complexity, in the form of the host institution and the supervisor who will devote their efforts into bridging the gap between the two thus-far m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Protein-protein interactions : biophysical and computational characterisation of growth factor-receptor binding and application to drug design' in the context of a Fifth Framework call.

assistant: **Objectives**

This project proposes to study the binding determinants and mechanism of the growth factor-receptor association by protein crystallography, docking, and biophysical analysis. The ultimate goal is the design of small molecules targeting these protein-protein interactions for therapeutically purposes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Ribitol-phosphate: chemical tools to probe the biology of a unique mammalian carbohydrate'.

assistant: **Objectives**

Cell-surface proteins are decorated with a variety of different carbohydrate structures that play central roles in mammalian biology. The complex nature of glycan structures and the pathways by which they are assembled make it a challenging task to decipher their exact function in cells, knowledge that is essential if we are to understand how malfunctioning leads to disease. This proposal aims to deliver innovative approaches to probe a distinct pathway of glycosylation essential to mammalian biology and to use these strategies to provide novel insights into the mechanisms underlying normal cellular functioning and disease pathology. The work programme is built around a specific type of O-linked cell-surface glycan that carries two critical ribitol-phosphate (RboP) residues, unique carbohydrates that so far have not been identified in other mammalian glycoconjugates. Failure to correctly assemble this glycan causes a range of congenital muscular dystrophies known as α-dystroglycanopathies. Despite its importance in disease pathology, many aspects of RboP utilisation and functioning in mammalian cells are poorly understood. The proposed programme offers a powerful and original approach to address these key issues in cell biology by creating a set of novel chemical tools. These tools will enable the probing and manipulation of both RboP-carrying glycoconjugates as well as the enzymes responsible for installing RboP onto the glycans in a cellular context. Integration of these tools with fundamental 3-D structural information and studies in cellular models of α-dystroglycanopathy will offer the unprecedented opportunity to directly link genetic defects to molecular and cellular aspects of enzyme function and through to observed changes in glycosylation status. These pioneer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular mechanisms of the formation and early function of calyx of Held synapses in the auditory brainstem' (2007-2013).

assistant: **Innovation**

My long-term goal for an independent research career is to carry forward the understanding of the central auditory system physiology and the molecular mechanisms that underlie its plasticity. Defects in this system may cause several diseases such as auditory neuropathies, tinnitus or impairments in language understanding. For this long-term purpose, I will do my post-doctoral experience in the laboratory of Pr. Schneggenburger (Brain Mind Institute/Ecole Polytechnique Fédérale de Lausanne/Switzerland) who is a world specialist in the study of the calyx of Held, a model synapse that belongs to the brainstem auditory pathway. The overall objective of this proposal is to gain insight into the molecular cues that determine the formation of the large calyces of Held synapses in the auditory brainstem. Calyces of Held are large excitatory glutamatergic synapses of the superior olivary complex, which rapidly relay information on sounds arriving at the contralateral ear. They thus play a role in sound source localization. Despite their important function, the molecular mechanisms which guarantee the correct formation of these synapses during development are unknown. In this project, we will therefore seek to answer the following two questions: 1) What are the molecular mechanisms that guarantee the formation of large calyces of Held synapses on the contralateral side of the brain, 2) What is the role of the Wnt signaling pathway in axon remodeling that ultimately leads to the formation of the large calyx of Held synapse.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'UKraine Replication, Awareness and INnovation based on EGNSS'.

assistant: **Objectives**

The objective of the UKRAINE project, in line with GALILEO-3-2014 Call, are to foster application development through international cooperation and to create a broad acceptance of EGNSS in Ukraine, creating at the same time opportunities both for knowledge building and at commercial level. The contribution of the UKRAINE project with respect to the aforementioned objectives relates to the achievement of the following impacts:- preparation of the Ukrainian aviation market to the extension of EGNOS- support to the uptake of regulated EGNSS applications through the elaboration of a legislative roadmap- generation of innovative solutions for multimodal logistics and dangerous goods- creation of business matchmaking opportunities for Ukrainian and EU companiesThese impacts will be achived by a set of coordinated actions:1. performing a study on integrating the Ukrainian legal framework to key European directives and regulations on EGNSS transport2. working on aviation as the starting point for the extension of EGNOS to Ukraine, by a) preparing the ground for LPV procedures, b) working on GNSS signal monitoring and c) setting the required legal framework3. innovating in the field of EGNSS tracking and tracing of Dangerous Goods and performing a pilot on multimodal freight transport4. creating business matchmaking opportunities between EU and Ukrainian companies and engaging GNSS stakeholders through a contest on a multiconstellation receiver5. disseminating results through pilots, demonstrators and an extensive communication campaignThe maximum possible involvement of Ukrainian stakeholders will be ensured by a) the direct involvement of the State Space Agency of Ukraine, the National Aviation University and the Technical Polytechnic of Kiev (KPI), b) the organization of even