RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ARAID-European Union Attraction of Researchers and Fellowship Program' (ARAIDEU), addressing dissemination and exploitation.

assistant: **Impact**

ARAID (Agencia Aragonesa para la Investigación y Desarrollo) Foundation is an Agency created by the Government of Aragon with the aim of promoting research, development and innovation in the region Aragon. It is a non-profit organization, with the legal status of a Foundation. ARAID Foundation operates as beneficiary and will manage ARAIDEU (ARAID-European Union Fellowships) attraction of researchers Program throughout its whole duration. The ARAIDEU Program will last 48 months and disseminate 3 calls for applications between month 1 and month 18 targeting the selection of 24 experienced research fellows and their attraction to any Research Host Institutions in the Aragon region. Information concerning the selection timetables and procedures will be available at the Project website (www.araid.es), and specific information will be updated at each launch of call for applications. The selection procedure of ARAIDEU Fellowship Programme will consist of three phases:  Publication of the call and reception applications, Evaluation of applications, Negotiation and Interview: Contract agreement and project start date. The program will ensure an appropriate management with revision of the program plan and is expected to continue in time after the EU-COFUND financing stops. Most of the fellowships if not all will be converted into long term (equivalent to tenure positions) contracts funded by the Government of Aragon to continue research projects with the Foundation support and as part of the staff of the Host Institution. This will depend on a post fellowship assessment on the evolution of the research projects and the available regional funding after the COFUND period.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Molecular Anatomy of Neurons'.

assistant: **Innovation**

The brain is nowadays the object of a number of extensive systematic studies that focus on seemingly all aspects of its morphology and function, from overall brain architecture to neuronal connections, neuronal morphology and gene expression. However, at least one basic aspect is as yet incompletely studied: the molecular anatomy of the neuron, i.e., the copy numbers and the spatial arrangement of molecules within the neuronal cell. This cannot be addressed by gene expression or proteomics approaches, as they do not have sufficient spatial precision. Electron microscopy, ideal for unraveling the neuronal morphology, does not have sufficient protein labeling efficiency. My project aims to fill this gap by a combination of super-resolution fluorescence microscopy, advanced fluorescence labelling techniques and advanced biochemistry tools such as quantitative mass spectometry. My objectives are fourfold: 1) to determine the molecular organization of at least 200 major neuronal proteins: their exact copy numbers and their position within the cell determined with nanoscale precision; 2) to generate a bank of biochemistry and microscopy sample preparations that will be available world-wide for the characterization of 1000-2000 additional proteins; 3) to integrate results into an in silico neuronal model that can be used for modelling functional neuronal parameters; 4) to use this technology to determine the changes in neuronal anatomy caused by neurodegeneration in Alzheimer’s and Parkinson’s Diseases. My group has already performed key preliminary work towards these aims. Our preliminary work focused on the synapse, where we ascertained copy numbers and positions for proteins adding up to more than 50% of the synapse’s protein mass (see figure). We are thus ready to embark o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multi-Modal Situation Assessment & Analytics Platform' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

MOSAIC Platform will involve multi-modal data intelligence capture and analytics including video and text collaterals etc. The distributed intelligence within the platform enables decision support for automated detection, recognition, geo-location and mapping, including intelligent decision support at various levels to enhance situation awareness, surveillance targeting and camera handover; these involve level one fusion, and situation understanding to enable decision support and impact analysis at level two and three of situation assessment. Accordingly MOSAIC will  develop and validate: i) A framework for capturing and interpreting the use-context requirements underpinned by a standard data ontology to facilitate the tagging, search and fusion of data from distributed multi-media sensors, sources and databases, ii) A systems architecture to support wide area surveillance with edge and central fusion and decision support capabilities, iii) Algorithms, including hardware-accelerated ones for smart cameras, which enable disparate multi-media information correlation to form a common operating picture, including representation of the temporal information and aspects, iv) Tools and techniques for the extraction of key information from video, un-controlled text and databases using pattern recognition and behaviour modelling techniques, v) Algorithms and techniques to represent decisions and actions within a mathematical framework, and how this framework can be used to simulate the effects of disturbances on the system, vi) An integrated system solution based upon the proposed systems architecture and the above developed enabling technologies including techniques for tagging different multi-media types with descriptive metadata to support multi-level fusion and correlation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structure-properties of melt-spun bioplastic fibers in correlation with their biodegradation behaviour and mechanical performance' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Polymeric textile fibers, are one of the main sources of microplastics pollution in the open environment. The European Strategy for Plastics in a Circular Economy acknowledges the need for increased R&D on biodegradable polymers. A key challenge of biodegradable plastics is that the biodegradation rate and material performance (e.g. mechanical and thermal) very often oppose each other. It is therefore difficult to develop products that meet the performance requirements that users expect, and still offer a substantial ecological advantage through fast biodegradation in the open environment. It is of importance to the future health of humanity and the natural world that a well-performing, scalable, and affordable biodegradable textile fiber will be developed. As this is intrinsically difficult, we need more fundamental understanding on how molecular design parameters (e.g. chain stiffness and chain interactions) and physiochemical properties (e.g. crystallization) influence biodegradation behavior on the one hand and fiber spinning and fiber performance on the other hand. The key outcome of the project is a clear understanding of how we can influence the biodegradation of a fiber, whilst having a good spinning process and fiber performance. It is likely that besides understanding, actual novel biosynthetic fibers will be developed in this project. The applicant Dr. Mohammadreza Naeimirad is an expert in melt-spinning of fibers and he is supervised by Bas Krins from Senbis Polymer Innovations B.V. as the host organization, and Prof. Gert-Jan M Gruter from University of Amsterdam (UvA) for the secondment. Senbis provides unique expertise and facilities on melt-spinning and evaluation whereas the UvA does so in the area of synthesis and biodegradation.


**Keywords:** Biopla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamic study of shape and force generation by clathrin polymerization onto lipid membranes in vitro' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The “CLATHPOL” project focuses upon a fundamental aspect of Clathrin Coat Vesicle formation. The critical biochemical (clathrin/adaptor interactions, membrane composition) and physical parameters (deformation forces, role of pre-induced curvature) controlling the shape and polymerization rate of clathrin coats will be determined and the forces applied on the membrane by clathrin polymerization will be measured. The “CLATHPOL” project will investigate the complex interactions driving clathrin coat assembly by developing improved bio-mimetic model systems to capture the complexity of biological membranes. The kinetics of clathrin polymerization and the dynamics of membrane shape generation will be studied by fast videomicroscopy using a membrane sheet assay to track coat formation on membranes exposed to various mixtures of clathrin and adaptor proteins. Membrane deformations will also be visualized using fluorescently labeled proteins. In the second stage, the forces on the membrane caused by clathrin polymerization will be measured using Giant Unilamellar Vesicles (GUVs). The membrane tension of the GUVs will be modulated by micropipette aspiration while membrane rigidity will be varied by changing lipid composition. Finally, the influence of membrane curvature on the dynamics and structure/geometry of the clathrin lattice will be determined using nano-patterned substrates with controllable and well-defined surface curvature. Membrane binding and lattice formation will be followed by Total internal reflection fluorescence (TIRF) microscopy and high speed atomic force microscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Study of Nitric Oxide Synthase in Amphioxus' (AMPHIOXUSNOS) targeting Seventh Framework.

assistant: **Abstract**

It is clear that a conserved set of developmental genes is shared between animals, but it is becoming even more evident that changes in gene regulation rather than changes in gene function may have been involved in the origin of morphological novelties and complexity during animal evolution. The candidate is interested in the study of the Nitric Oxide Synthase (NOS) family evolution, its regulation during development and its biomedical importance being implicated in the physiopatology of many human diseases. Nitric oxide (NO) is an essential molecule to many physiological functions including neurotrasmission, learning and memory, cardiovascular homeostasis, angiogenesis, immune response, development and apoptosis. NO, probably one of the oldest bioregulatory systems controlling metazoan physiology, is a diffusible highly reactive gas produced by the enzymatic conversion of L-arginine by Nitric Oxide Synthases (NOS).The aim of the proposal is the study of the expression pattern and regulation of three different NOS genes in the chordate amphioxus, a marine invertebrate organism, in order to find out vertebrates ancestral functions. Amphioxus is the best available stand-in for the proximate invertebrate ancestor of the vertebrates, with a body plan and a genome that are vertebrate-like, but simpler. The comparison of multiple NO/NOs roles between different animal models would elucidate new functions as well as to improve our understanding of NOS function in both physiological and pathological conditions in humans.The candidate will setup an amphioxus facility in the Host Institution, the Stazione Zoologica Anton Dohrn of Napoli (Italy), which is very suitable for the project’s success, being a marine laboratory with a long history in studies of comparative embryology and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'STRUCTURE AND DYNAMICS OF PORPHYRIN-BASED MATERIALS IN SOLUTION vs. INTERFACES' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal of the proposed project is to perform a systematic study of the electronic structure and the dynamic behaviour of specifically selected metalloporphyrin materials in solution, and at liquid-solid interfaces, with a time resolution covering the range from sub-femtosecond up to picoseconds which is fundamental for their biochemical properties. Metalloporphyrins play a key role in a wide range of processes, such as the light energy conversion in photosynthesis, or in haem proteins performing the transport of small ligands like oxygen. Because of their peculiar optical, electronic and magnetic properties, they are potential candidates for technological applications like in molecular electronics. It is of fundamental importance to gain a detailed understanding of the structural and dynamic properties of these materials under realistic conditions (i.e. ambient pressure, room temperature, and in heterogeneous environments). Soft X-ray spectroscopy is an ideal tool for this purpose, which has recently been implemented by the PI for the investigation of applied materials in the liquid phase, drawing on international recognition of his achievements. Taking advantage from his broad expertise, the PI extended the soft X-ray spectroscopy to biochemical systems in solutions for the first time. Since last year the PI became the youngest group leader at HZB, and Junior Professor at the Freie Universität Berlin. Here, the PI proposes to use the laser pump / soft X-ray probe spectroscopy at first in the sub-picosecond domain. The experiments will extended to femtosecond resolution at the X-ray Free Electron Laser facility. To address sub-femtosecond processes, the systematic scanning of the systems with core-clock spectroscopy is intended. The study will provide fundamental know
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Bridging the gap between science and producers to support the European marine mollusc production sector'.

assistant: **Innovation**

Under the acronym EUROSHELL, this proposal will provide solutions to identified challenges that may constrain the transfer of knowledge to the shellfish sector and thus affect its sustainable development.It will focus on identification of the underlying factors that inhibit effective knowledge management in the sector and provide regional forums to facilitate dialogue between shellfish companies (especially through their regional or national producers’ organisations) and researchers, with a strong focus on developing efficient methodology for knowledge transfer.This will result in the production of visions for the future of the sector and the identification of key research objectives that could be integrated in the European Aquaculture Technology and Innovation Platform (EATIP) and also provide clear cooperation opportunities with the Fisheries Local Action Groups (FLAGS) of the European Fisheries Areas Network (FARNET) through enhanced methodology for an extension network.The core objectives of EUROSHELL are to:•Enhance integration of knowledge into the production cycle of the main farmed species, by assessing current critical problems experienced by the sector that have a direct link to research and reviewing current knowledge and especially the extent of its uptake.•Assess the current structural organisation that links knowledge to practice in key European production countries and identify solutions that will address structural difficulties (where these exist) for shellfish SME’s to participate in RTDI initiatives.•Identify future visions for the European shellfish sector by industry, including the identification of gaps and research needs, so as to lay the basis for more effective methodology for future dialogue and possible integration of the sector into the EATIP.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Organoid technologies for disease modeling, drug discovery and development for rare diseases' (ORGESTRA) targeting Horizon Europe.

assistant: **Abstract**

The vast majority of rare diseases are characterized by genetic origin, often severe in pathology and with limited or no treatment options. This also includes the paediatric disorders cystic fibrosis (CF) and cystinosis. Both diseases usually manifest in the first year of life. In recent year, great progress has been made in CF research allowing a swift transfer of novel drugs from bench to bedside. This is fueled by the application of advanced in vitro models, viz. organoids, in phenotyping patients and personalize treatment options. In ORGESTRA, we propose to use stem cell-derived organoids to train 13 Doctoral Candidates (DCs) in developing personalized disease models for the lung and kidney diseases, CF and cystinosis, with significant unmet clinical needs. Research will aim to identify pathogenetic mechanisms and druggable targets, drug mode of action for effective and innovative treatment strategies, classify the pathway to clinic and address ethical and regulatory issues to foster acceptance and implementation of the organoid models. Eventually, a living technologies toolset will be developed for a swift transfer from bench to bedside. ORGESTRA will provide an international, intersectoral and interdisciplinary training by creating a new expert framework of 14 partners from 7 countries, combining molecular biologists, engineers, pharmacologists, clinicians, epidemiologists and ethicists, giving each DC unique, joint-doctoral training and tailored experience in industry and/or patient organisations, complemented with a rich workshop programme. The ORGESTRA objectives contribute perfectly to the Horizon Europe goals of the societal challenge on improving the health and well-being of the EU citizens.


**Keywords:** Precision medicine, Cystic Fibrosis, Cystinosis, cl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Solar-Driven MOF Membrane Fabrication from Waste for Sustainable Separations' in the context of a Horizon Europe call.

assistant: **Objectives**

Membrane-based separations are among the most energy-efficient alternatives to conventional processes such as distillation, yet the fabrication of high-performance membranes remains energy- and resource-intensive. Metal–organic framework (MOF) membranes offer exceptional selectivity and tunability for demanding separations, including propylene/propane (C₃H₆/C₃H₈) and lithium/magnesium (Li⁺/Mg²⁺), but current hydro/solvothermal fabrication methods require high temperatures, pressures, grid electricity, and purified chemical precursors. This project, SUN-MEM, introduces a solar-driven photoelectrochemical (PEC) platform for MOF membrane fabrication under ambient conditions, eliminating external electrical input and enabling off-grid operation. The method directly integrates waste valorisation by using zinc ions recovered from spent Zn–Mn batteries and terephthalic acid (TPA) from PET plastic waste as precursors. Solar illumination simultaneously drives anodic and cathodic interfacial reactions, lowering nucleation barriers, enabling rapid growth within one hour, and producing valuable H2 and O2 by-products. The approach is compatible with both imidazolate (ZIF-8) and carboxylate (UiO-66) chemistries, demonstrated on flat plate and hollow fiber substrates for industrial scalability. Compared with conventional synthesis, SUN-MEM can reduce electricity consumption by over 95%, precursor costs by 65%, and manufacturing CO2 emissions by 84%, while contributing to the upcycling of over 4.9 Mt PET and 34 kt battery waste generated annually in the EU. By bridging solar energy conversion, MOF membrane engineering, and circular economy principles, the project delivers a disruptive route to sustainable, energy-autonomous membrane manufacturing, aligned with the EU Green Deal and Zer