RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Personalized intracranial aneurysm rupture prognosis using Simulation-Based 4D Flow MRI and Machine Learning' in the context of a Horizon 2020 call.

assistant: **Objectives**

Unruptured intracranial aneurysm (UIA) is a severe, relatively common cerebrovascular disorder in the general population. Although such aneurysms are mostly asymptomatic and may not burst, a considerable number of UIA patients remain on a high risk of aneurysm rupture, a serious life-threatening condition. Thus, is crucial to decide the timing and type (clipping, coils, and/or stent, flow diverter) of surgical intervention. However, the optimal management strategy of UIA is still open to clinical debate, with recommendations for elective repair after diagnosis based primarily on the aneurysm size and location. While cardiovascular flow imaging has strong potential to provide the required information for surgical decision-making, currently, flow imaging and assessment is not sufficient to reliably predict rupture and quantitatively assess the risk of haemorrhage. By identifying factors contributing to UIA rupture and by incorporating advanced computational techniques, i.e. 4D flow magnetic resonance imaging (MRI), machine learning (ML) algorithms, and computational fluid dynamics (CFD) models, this project will technologically advance quantification of rupture risk assessment on an UIA patient-specific basis.This project, Sim4DFlow, core technological aim is to develop a novel simulation-based imaging framework that can integrate the advanced computational techniques of 4D flow MRI, ML, and CFD. Subsequently, Sim4DFlow will test and validate the framework prognostic capacity in the laboratory setting against relevant data of UIA patients.


**Keywords:** intracranial aneurysm,  medical imaging,  MRI,  4D Flow MRI,  computational mechanics,  fluid dynamics simulation,  imaged-based modeling,  risk prediction,  machine learning,  prognosis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Advanced corrosion monitoring technologies for safety critical structures : dissemination of information'.

assistant: **Concept**

Increasing environmental awareness places high demands on the integrity of industrial plants. Many safety critical structures in these plants are subject to degradation mechanisms, with corrosion being one of the most important. Regular structural inspection is used for assuring safe operation. In many cases inspection with classic techniques requires taking the structure out of service and dismantling it. A number of non intrusive corrosion monitoring technologies have recently been developed which can be used as a substitution for classic techniques, but their widespread use has been prevented by insufficient knowledge about the techniques among the inspection community. This project aims at combining knowledge about advanced corrosion monitoring and disseminating it on a large scale throughout the inspection community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Galois theory of periods and applications.'.

assistant: **Innovation**

A period is a complex number defined by the integral of an algebraic differential form over a region defined by polynomial inequalities. Examples include: algebraic numbers, elliptic integrals, and Feynman integrals in high-energy physics. Many problems in mathematics can be cast as a statement involving periods. A deep idea, based on Grothendieck's philosophy of motives, is that there should be a Galois theory of periods, generalising classical Galois theory for algebraic numbers. This reposes on inaccessible conjectures in transcendence theory, but these can be circumvented in many important cases using an elementary notion of motivic periods. This allows one to set up a working Galois theory of periods in many  situations of arithmetic and physical interest.These ideas grew out of the PI's recent proof of the Deligne-Ihara conjecture, in which the Galois theory of multiple zeta values  was worked out. Multiple zeta values are one of the most fundamental families of periods, and  their Galois group plays an important role in mathematics: it is conjecturally equal to  Drinfeld's Grothendieck-Teichmuller group, the stable derivation algebra on moduli spaces of curves, and the Galois group of mixed Tate motives over the integers. It occurs in deformation quantization, the homology of the graph complex, and the Kashiwara-Vergne problem, as well as having numerous connections to string theory, and quantum field theory.The goal of this proposal is to generalise this picture.  Periods of moduli spaces of curves, multiple L-functions of modular forms, and Feynman amplitudes in quantum field and string theory should each have their own Galois theorywhich is yet to be worked out. This is completely uncharted territory, and will have numerous applications to number theory, algeb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In-silico Development- and Clinical-Trial-Platform for Testing in-situ Tissue Engineered Heart Valves' in the context of a Horizon 2020 call.

assistant: **Objectives**

SimInSitu is aiming to develop a sophisticated in-silico method to predict the short- and long-term behavior of in-situ tissue engineered heart valves by combing advanced tissue remodeling algorithms with a personalized virtual heart modelling approach. The method will be specifically developed to predict the complex transformation process of biodegradable heart valves from the initially synthetic scaffold into a fully remodeled & functional valve. This transformation process, named ETR for Endogenous Tissue Restoration, is the core technology for a new generation of very promising biodegradable vascular device currently developed by Xeltis. ETR makes the use of animal derived tissue, which is used in the majority of commercially available bioprosthetic heart valves, obsolete and avoids thereby durability related issues and potentially minimized the need for reoperations. Though, significant progress was made during the past years in developing ERT based devices, it remains very challenging, costly, time-consuming, and rich with obstacles. New knowledge can only be generated through a tedious trial & error process (requiring preclinical and clinical studies), since the restorative process cannot be replicated in an in-vitro environment. Advanced Computer Modelling & Simulation technologies have the potential to overcome this limitation by allowing to test new designs, modified scaffold compositions, or other applications in a virtual patient-specific environment – in-silico. SimInSitu will not only develop such a computer model, but will also verify and validate it thoroughly by making use of the extensive in-vitro and in-vivo data available and where necessary will generate new data to support the credibility of this in-silico method. The availability of this computer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High Performance Modular Architecture of Acquisition and Control command system dedicated to test Electrical systems for Aeronautics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The HighPMAAC project will create, design, develop and validate a new High Performance Modular architecture of Acquisition and Control Command system dedicated to test Electrical Systems for Aeronautics in an efficient way.This new architecture will allow easily to perform tests in an “independent way” at the Equipment Level. We’ll then be able to perform tests at System Level, providing a full integrated test system. We’ll use a distributed synchronized front-ends system, with high capabilities in terms of synchronized data acquisition rate, simulation, synchronized stimulation, modularity and adaptability.The architecture will be based on modular subsystems allowing operators to adapt easily the front-ends to the characteristics and needs of each equipment. Synchronization mechanisms and monitoring at high data rate allow performing secure integration tests with high quality of acquired data, for a fine exploitation of electrical behaviour propagation.The whole system is validated through the Electrical Test Bench and constitutes the Control and command system of this ETB. Associated to the dedicated wiring, it will be possible to supervise tests of Aircraft representative power networks. It is also important to note that this distributed system will include simulation capabilities, implementing ""Hardware In The Loop"" possibilities and may address other application requiring combination of Supervision, Monitoring, high performance Data acquisition and exploitation.For this, the consortium -motivated by its will of sharing respective know-how- will invest in this project with the intention to being a key partner concerning this kind of needs in the future. It will set up the basic requirements of such a system, then conceive and develop the hardware and software solu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study of neutron star crust with solid state theory' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The inner neutron star crust, composed of a lattice of nuclei immersed in a neutron superfluid, plays an important role in our understanding of many observational issues, such as pulsar glitches, thermal emission and cooling or gravitational wave instabili ties. The growing number of data in the whole electromagnetic spectrum and the imminent rising of the gravitational wave astronomy urge the need for a deep theoretical study of the neutron star crust. This is even more so as a detailed analysis of the crus t composition is essential to evaluate the possible contribution of neutron stars to the galactic enrichment in the so-called r-process nuclei, the origin of which remains one major mystery in nuclear astrophysics. Despite the close analogy between free ne utrons in the crust and free electrons in solids, solid state physics concepts have not yet permeated nuclear astrophysics. In particular, Bragg scattering, which is crucial for the understanding of transport properties, has been entirely neglected for mor e than three decades. The aim of the project is to change this situation by adapting to the nuclear context the band theory of solids, which has been very successful in describing electronic, photonic and phononic materials. We want to apply it to the stud y of neutron star crusts by solving the Hartree-Fock-Bogoliubov equations. The Institut d'Astronomie et d'Astrophysique of the Universite Libre de Bruxelles is an ideal place to achieve this goal and to examine the astrophysics consequences of the emerging model. This institute is recognized worldwide as a center of excellence in nuclear astrophysics. It has a substantial expertise in the development of mean field models and of their application to a large variety of nuclear problems. This project, by estab li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Defining the Biomechanics of the Developing Heart through High-Speed Dynamic Fluorescent Imaging in Transgenic Quail Embryos' (DynImHeart).

assistant: **Innovation**

Vertebrate heart morphogenesis is a complex process that integrates different structures and cell types compelled to interact by genetic and epigenetic factors. Mistakes at any step from  cell-commitment to valve formation will have a major impact on heart morphogenesis leading to congenital heart disease. Avian embryos offer an ideal system to study heart development because the development of the four-chambered avian heart is comparable to that of the four-chambered mammalian heart. The avian embryo is readily amenable for optical accessibility and permits direct observation of the cellular movements comprising heart formation in a warm-blooded experimental system. We use quail because of their small sized eggs, their moderately sized breeding adults, their short generation time, and their transgenic feasibility. The transgenic quails developed in the hosting laboratory expressing fluorescent proteins constitute a new model syste. Bright trangenic quails improve the ability to dynamically image vascular development during embryogenesis.Our proposal aims to study the formation of the heart during the embryonic development of quails with special attention to fate mapping myocardium and endocardium progenitors. We will carry out dynamic imaging, using laser scanning microscopes, to image live transgenic or chimeric quail lines that express fluorescent proteins ubiquitously, in the endocardium and in additional tissues or subcellular structures. Using a high-speed confocal microscope we aim to capture the heartbeat at different z-depths. We can reconstruct the data into a 4D figure allowing us to conclude the impedance action of the heart on the endocardium wall.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Intelligent control system based on smart textiles to reduce pressure ulcer risk by real time measuring of tissue viability and intelligent trigger of prevention strategies adapted to user and context' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The aim is to convert the functional prototype from FP7 PUMA project into a commercially-ready intelligent control system and to introduce this new solution for Pressure Ulcer (PU) prevention in the European Assistive Technologies market. The novelties of i-LiveRest are a) to measure PU risk in real time based on Tissue Viability (TV) with impedance, pressure, temperature and humidity textile sensors; and b) to decide the best combination of PU prevention strategies based on risk, user and context. It can be embedded on wheelchair and mattresses. i-LiveRest will be the first ICT solution applied to PU risk detection and prevention.PU are preventable but 38% of PU appear using current devices because a) risk,  user status and context are not taken into account; and b) PU risk assessment is only based on pressure instead of TV. There is no available solution able to provide the functionalities of i-LiveRest.Target customers are Spinal Cord Injury (SCI) patients, healthcare public bodies and private insurances. On the one hand, SCI will develop a PU during their lifetime and 7-8% will die. i-LiveRest will increase their sitting time, enhancing their independent living. On the other hand, i-LiveRest will reduce public and private costs related to PU treatment (20 B€/year); injuries of professionals due to manual repositioning (2,000 M€/year); and will increase labour force of SCI and their relatives.In Phase 1, we need to: assess the technical and economic viability of industrialising i-LiveRest by optimising components; identify providers; prepare CE mark; identify purchasing agents; contact stakeholders; and elaborate a business plan. In Phase 2, we will optimise i-LiveRest system to reduce components size and costs, achieve CE mark and perform a pilot demonstration in fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sensor arrays for environmental, generic and routine detection of pesticides' (SAFEGARD), addressing dissemination and exploitation.

assistant: **Impact**

The SAFEGARD project is designed to systematically evaluate novel enzymes, produced by molecular biology techniques to be selectively responsive and sensitive to the presence of pesticides. These enzymes will be the basis for the production established sensors, able to rapidly and routinely quantify pesticides in water another environmental samples at concentrations below recommended acceptance levels. The sensors will be fabricated by advanced interfacial techniques usingnanobiotechnology, structural modelling, electrochemical approaches and incorporated into arrays. Instrumentation will be produced, with software control, data processing, chemo metric analysis and routine monitoring capabilities. Evaluation of the sensor arrays and instrumentation will also be performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SERENITY-X – Accelerating AI' (SERENITY-X).

assistant: **Concept**

The ERC frontier project ADG-670406 develops a novel very high performance tracking calorimeter for the precise measurement of the energy of the particles produced in high-energy collisions. One of the key challenges that we have had to overcome is that of reading out the unprecedented quantity of information that such a calorimeter produces. To address this we have developed a novel, state-of-the-art FPGA based digital platform (SERENITY), including machine learning. We have developed a generic platform that has potentially very wide applicability wherever there are high data rates or high throughput. This PoC seeks to apply this technology in the wider context, from the health to security and fintech sectors.


**Keywords:** High throughput digital electronics, FPGA, AI , machine learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Genetic and Environmental Mechanisms Underlying Hypercoagulability and Impaired Fibrinolytic Function Predisposing to Coronary Artery Disease' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

- To elucidate gene-environment interactions for the haemostatic proteins fibrinogen, coagulation factor VII and plasminogen activator inhibitor-1 (PAI- 1) determining the risk of atherothrombosis and coronary heart disease.- To establish whether there are cross-cultural differences between countries in Europe in these respects.The project has three parts: I) A large-scale cross-cultural study of gene-environment interactions influencing the three major haemostatic risk factors for CHD (fibrinogen, factor VII and PAI-1) in individuals with and without manifest CHD in four countries in Europe with a different incidence of CHD; II) Detailed clinical and biochemical studies in individuals with specific single gene genotypes or multiple gene genotypes selected from the populations recruited to the cross-cultural study; and III) Molecular biological and molecular genetic studies of mechanisms regulating the plasma levels of fibrinogen, factor VII and PAI-1 and their relationships to CHD. Genotyping will be performed at 4 loci in all participants in the cross-cultural study: beta-fibrinogen promoter (G453-A), factor VII (Arg353-Gln), PAI-1 promoter (4G/5G) and factor V (Arg506-Gln). The associations between genotypes and levels of therelevant haemostatic proteins will be examined to address the following questions: i) Is the effect of genotype on determining the plasma levels of the relevant protein larger in patients than in controls? ii) Is the effect of genotype on determining the plasma levels of the relevant protein larger in individuals selected from countries with a higher incidence of premature CHD? iii) Do significant gene-environment interactions exist, i.e. are there allele-specific differences in the influence of various environmental factors on the expression of