RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of COMBInatorial BIOmarkers for subclinical atherosclerosis'.

assistant: **Objectives**

Systems biology involves the analysis of relationships among the elements in a system, viewed as an integrated and interacting network of genes, proteins and biochemical reactions. We have pioneered the use of metabolic profiling and the metabolome-wide association study (MWAS) approach, involving high-throughput spectroscopic screening, to capture comprehensive data on a range of exposures affecting disease risk from genetic, lifestyle, gut microbial and xenobiotic sources. Cardiovascular disease is the leading cause of death worldwide. It is a late manifestation of the pathophysiological processes leading to development of atherosclerosis, starting early in life. There is urgent clinical need to identify predictive combinatorial biomarkers for subclinical atherosclerosis, to allow preventive/treatment strategies to be instituted early in the disease process. Our proposal brings together leaders in metabolic profiling and computational medicine for analysis of multi-omics data, and leading European/US prospective cohorts with subclinical atherosclerosis measurements. We propose to apply untargeted metabolic profiling using both proton Nuclear Magnetic Resonance spectroscopy (1H NMR) and Mass Spectrometry (MS) to discover novel biomarkers for subclinical atherosclerosis in stored serum samples from 4,000 people, with validation in stored samples from a further 4,000 people. We will develop and apply methods for investigating cross-platform (NMR, MS) and multi-omics (genome-wide, metabolome-wide) relationships to gain better understanding of underlying biochemical connectivities and pathways. For identified/validated novel and established/emerging biomarkers, we will develop a predictive combinatorial set of biomarkers and risk scores for subclinical atherosclerosis. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Boosting Efficiency and Stability of Tin-Lead Perovskite Photovoltaics with Chemically Smart Device Architectures' under Horizon Europe.

assistant: **Concept**

Perovskite photovoltaics offer a low-cost, high-efficiency solution to speed up the transition to net-zero emissions. In particular, tin-lead perovskite solar cells have ideal optical properties for peak performance. However, their large-scale use is hampered by stability issues at perovskite surfaces, i.e., oxidation, vulnerable defects, and chemical mismatch with ordinary charge transport layers in solar cells. Self-assembled monolayers (SAMs) are alternative transport layers that allow the manipulation of critical interface regions, yet their use in tin-lead perovskite photovoltaics remains in its infancy. Careful choice of SAM functional groups, molecular structure and redox chemistry are key to tackle perovskite limitations.SAMper will develop ultrastable and highly efficient tin-lead perovskite solar cells by designing SAM device architectures with interface-specific smart functionality. Defect-passivating, perovskite-healing and oxidant scavenging SAM moieties will afford the targeted properties, as will be demonstrated via structural, chemical and electrical interface analysis. Top SAM-based devices will be tested outdoors to demonstrate their excellent durability and efficiency, comprising the first example of tin-lead perovskite solar cell testing under real-world conditions and paving the way towards their commercial deployment.SAMper contributes towards clean energy in alignment with European Green Deal decarbonisation targets. The project will further the researcher's excellence and career prospects via training on cutting-edge multidisciplinary research. Knowledge transfer with the supervisor will foster the researcher's scientific independence via key management skills. The secondment for outdoor tests will facilitate international synergies. Project outp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'AI for REAL-world NETwork operation' (AI4REALNET), addressing dissemination and exploitation.

assistant: **Impact**

The scope of AI4REALNET covers the perspective of AI-based solutions addressing critical systems (electricity, railway, and air traffic management) modelled by networks that can be simulated, and are traditionally operated by humans, and where AI systems complement and augment human abilities. It has two main strategic goals: 1) to develop the next generation of decision-making methods powered by supervised and reinforcement learning, which aim at trustworthiness in AI-assisted human control with augmented cognition, hybrid human-AI co-learning and autonomous AI, with the resilience, safety, and security of critical infrastructures as core requirements, and 2) to boost the development and validation of novel AI algorithms, by the consortium and AI community, through existing open-source digital environments capable of emulating realistic scenarios of physical systems operation and human decision-making.The core elements are: a) AI algorithms mainly composed by supervised and reinforcement learning, unifying the benefits of existing heuristics, physical modelling of these complex systems and learning methods, as well as, a set of complementary techniques to enhance transparency, safety, explainability and human acceptance; b) human-in-the-loop decision making for co-learning between AI and humans, considering integration of model uncertainty, human cognitive load and trust; c) autonomous AI systems relying on human supervision, embedded with human domain knowledge and safety rules.The AI4REALNET framework will be validated in 6 uses cases driven by industry requirements, across 3 network infrastructures with common properties. The use cases are focused on critical challenges and tasks of network operators, considering strategic long-term goals, such as decarbonisation, d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Emotional Acculturation:  Emotions as Gateways to Minority Inclusion'.

assistant: **Innovation**

International migration has often been referred to as one of the major challenges of the 21st century. Numbers of immigrants have been increasing, but social integration of migrants and their children is lagging at the detriment of immigrant minorities themselves and often resulting in conflict within receiving societies. EmotionAcculturation investigates the role of emotions, as key processes of interaction, for immigrant minorities social inclusion, and their wellbeing. It builds on research showing that, in each culture, emotions are socialized to fit the most valued kinds of relationships, and that the prevalent emotions, therefore, vary across different cultures. I postulate that misfit of the emotions of immigrant minorities with the typical majority emotions compromises interactions, and that this will hamper their social integration, and therefore their opportunities in the larger society. I study how and when emotional acculturation forms an important gateway to the social inclusion and wellbeing of immigrant minority individuals. The grant is organized around three Objectives: to better understand 1) the nature of emotional acculturation, 2) its conditions, and 3) its outcomes. I adopt a multi-method approach, following large numbers of immigrant minority and majority participants over time, in their everyday lives, and in real-time interactions in the laboratory. The project will span two receiving national contexts with different diversity climates (Belgium, California). It will shed light on understudied micro-processes involved in minority inclusion, and their social and health consequences. EmotionAcculturation offers a novel approach to psychological acculturation that goes beyond attitude change. Moreover, by studying emotional change beyond childhood,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nanocoating deposition of anti-fingerprint and fluorine free material on glass for optical lenses and solar panels industry', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Today the glass lenses and solar panels have a low durability and are easily stained with undesirable fingerprint, oil, dust and environmental pollutants decreasing the efficiency of their optical properties and generating and extra cost and time for their cleaning. In addition, the most current approaches for achieving an amphiphobic material (repels water and oil) rely on fluorinated compounds such as perfluoroalkyl sulfonates (PFAS)s. However, these fluorinated compounds may be carcinogenic for animal and humans at relatively high dose levels with strong evidence for connection between exposure to them and several forms of cancer. There is a necessity to find an effective, self-cleaning material with a high durability that provides glass surfaces with a high resistance to ngerprinting.  In response, our companies ONYRIQ (ON) and ADVANCED NANOTECHNOLOGIES (AD) have developed NaDam-G (Nanocoating Deposition of amphiphobic and fluorine free material on Glass), an innovative  technology consisting of a fluorine-free(avoiding the damage to health and environment), anti-fingerprint (avoidance of fingerprint and smudges) and self-cleaning (inherent ability to remove dirt), polymeric material covalently bonded on glass by Plasma Enhanced Chemical Vapour Deposition (PECVD). NaDam-G imparts  high-durability for optical lenses and solar panels (increasing the efficiency by 3.5 % and generating an extra 25% of electricity) while being self- cleaning reduces cost and time consuming. Having validated the reliability of the NaDam-G system at the pilot scale, we now want to finalise its development and achieve market preparedness. In Phase 1 we aim to carry a Feasibility Study to warrant the project from a technical, commercial and financial point of view. Besides the crucial benefi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CARdiomyopathy in type 2 DIAbetes mellitus' under Horizon 2020.

assistant: **Concept**

A rapidly evolving epidemic in Type 2 Diabetes (T2DM) is afflicting all ages, sexes and socioeconomic classes which includes serious comorbidities such as heart diseases. While ischaemic heart disease represents the major cause of death of T2DM patients, heart failure (80% of Heart Failure with preserved Ejection Fraction) is the second most common cardiovascular disease in T2DM patients. The aim of CARDIATEAM is to determine whether T2DM represents a central mechanism contributing to the pathogenesis and progression of a specific cardiomyopathy, called “diabetic cardiomyopathy” (DCM), assessing whether DCM is unique and distinct from the other forms of heart failure.To achieve this aim CARDIATEAM will build up a deeply phenotyped cohort, including an innovative imaging protocol, based on privileged access within the CARDIATEAM to already existing highly pertinent cohorts of diabetes and heart failure patients and control groups. Central biobanking of the cohort samples will allow detailed omics analysis that will feed together with the phenotype and imaging data into the central CARDIATEAM database. The data gathered will enable unsupervised machine-learning for clustering this heterogeneous population on phenotypic differences beyond diabetes. State-of-the-art big-data processing techniques and disease modeling will allow for controlling for common confounders such as BMI, smoking, age and blood pressure and will finally lead to the identification of new imaging and molecular biomarkers as well as understanding the taxonomy of the development and progression of DCM. Tailored preclinical models will be developed to explore the identified pathways revealing new therapeutic targets.The results of CARDIATEAM will be able to impact clinical care with the stratification of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular mechanisms of androgen resistance in prostate cancer' (ARPC), addressing dissemination and exploitation.

assistant: **Impact**

Prostate cancer is the second cause of cancer death in men and will represent an increasing burden on European health care systems due the ageing trend of the population. Current therapies can often not prevent progression to the hormone-refractory stage, against which no efficient treatment exists. The pivotal role of the androgen receptor, also in the late phases is documented by numerous studies. A joint effort involving participants from the clinical side, academic research and industrial research is proposed to decipher the molecular mechanisms responsible for the growth and spread of prostate cancer, and identify suitable targets for the development of novel compounds for treatment of prostate cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Targeting alpha-particle emitting radionuclides to combat cancer' in the context of a Seventh Framework call.

assistant: **Objectives**

This project aims at improving drug delivery to cancer cells by developing targeted radiotherapy with alpha-emitting radionuclides. Alpha particles emitted by radionuclides have short tracks (about 100 microns) in body tissues. As a result, they should be most appropriate to treat small-size tumours and isolated cancer cells. This project proposes the development of improved vectors and targeting technology based on specific targeting agents (recombinant antibody fragments and synthetic peptides), pretargeting approaches and nano-colloids especially designed to deliver alpha-emitting radionuclides to cancer cells after local or systemic administration. The concept of in situ generator, that allows the use of longer half-life parents of alpha-emitting radionuclides will be developed. Several approaches to prevent the release of radionuclides after parent isotope disintegration, including encapsulation in nano-colloids, are proposed. Improved targeting methods will be tested in animal models of small-size tumours and associated dosimetry (including micro-dosimetry) and toxicity studies will be performed. The final goal of the project will be to propose one or several new products for targeted delivery of alpha-emitting radionuclides for clinical development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Multidimensional Analysis of Risks and Shocks in Developing Countries'.

assistant: **Concept**

This research project addresses how various risk factors in developing countries impact individual behavior and subsequent welfare. In an increasingly interconnected world, people face a multitude of economic, social, environmental, and political risks, with shocks often interdependent and occurring simultaneously. This project aims to contribute to a better understanding of the consequences of such shock experiences from a micro-level perspective.The analysis, which will be based on the existing literature that addresses the reactions to and effects of selected shocks, will combine exceptionally detailed household survey with disaster event data from Indonesia and Colombia, two countries exposed to recent natural and human-induced shocks. State-of-the-art econometric techniques allow addressing some of the open methodological issues in the field and will lead to a comprehensive and comparative study of post-shock coping strategies and its welfare implications.The project will be implemented at the Université de la Méditerranée Aix-Marseille II (UnivMed), which has a strong focus on quantitative development economics and, moreover, provides an outstanding pool of econometric knowledge that is critical for the successful implementation of this methodologically demanding research. The researcher will use the fellowship to further deepen his research capacities, to expand his management and organizational skills, and to gain teaching and supervision experience, all of which contributes to the achievement of his career goals in academia.Finally, from a European policy perspective, the project aims at guiding social policies in alleviating the consequences of adverse shocks on poor households. Based on evidence-driven insights, the outcomes of this project should help to eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sub-Terahertz Analog-to-Digital Conversion Using Integrated Soliton Microcombs' (CompADC).

assistant: **Concept**

Modern information and communication technology has been propelling the rapid expansion of signal spectrum bandwidth towards the level of hundreds of GHz and even 1 Terahertz. Such wideband analog signals produced in physical world must be converted to a stream of data bits via analog-to-digital conversion (ADC), for ultra-fast and flexible digital signal processing (DSP). However, the random electron fluctuations in semiconductors set a fundamental limitation on the performance of electronic (ADCs), leading to an inherent trade-off between the sampling accuracy and bandwidth. State-of-the-art electronic ADCs typically have only GHz-level analog bandwidth, which is becoming an increasingly severe limitation on high-speed DSP applications. Although the adoption of mode-locked lasers (MLLs) can overcome some limitations using the ultra-stable pulse train for precise time-domain sampling, the GHz-level repetition rate and the challenging integration of MLLs prevents any usability of photonics-assisted ADC in practical applications.   In the CompADC project, I propose to develop a radically-new photonic ADC scheme using chip-scale dual optical frequency combs, enabling real-time digitization of ultra-wideband RF and microwave signals with a bandwidth of > 100 GHz. This envisaged performance is enabled by the emerging dissipative Kerr soliton (DKS) microcombs generated in SiN microresonators, which produces a new type of on-chip mode-locked emission of optical pulses with repetition rates exceeding 100 GH. These phase-locked dual microcombs (signal comb and local oscillator comb) will perform precise frequency-domain decomposition and parallel frequency down-conversion of ultra-wideband microwave signals to the detectable range of lower-speed electronics. This CompADC approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Studies in nanoscale magnetism: Core/shell magnetic nano-architectures in biology and materials science' (COMAGMAT).

assistant: **Concept**

The project will focus on two areas of research in iron-based systems of biotechnological interest:1) Nanomagnetism of tissue and recombinant wild-type and mutant ferritins; and2) Nanomagnetism of silica coated magnetic particle/quantum dot (MP/QD) (-Fe 2O3 /CdSe) hybrids; and, -Fe2O3 solid-silica core-mesoporous silica shell nano-architectures.These systems are of interest due to their broad areas of application in materials, biology and medicine; and as experimental model systems for fundamental studies in magnetism. Magnetic measurements (SQUID) and high and low field Mössbauer spectroscopy, over a wide range of temperature and applied magnetic fields, will probe dynamic magnetic processes in these systems. The process of biomineralization of inorganic compounds on organic substrates in biology is at the centre of nanoscience and nanotechnology that seek to emulate nature in the production of new materials. The rigid molecular template of ferritin is the prototypical system for iron biomineralization research, catalysing space-confined iron nucleation at the nanoscale.The magnetic properties of ferritin have inspired the fast growing field of clinical and medical applications of magnetic carriers (MRI enhancement, targeted drug delivery, cancer hyperthermia therapy, and magnetic relaxation switches for DNA and virus detection, etc.) leading to an intense international effort for the production of bio-compatible and bio-functionalised magnetic core/shell nanostructures.As proposed here, silica encapsulation of nanoparticles provides for water-solubility, biocompatibility and easy surface modification for bio-conjugation. In addition, ferritin and its closely related protein, haemosiderin, are implicated in hemoglobin disorder associated diseases, such as - and ß- thal