RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Inspection and surveillance of metallic pressure vessels during the proof test' under Fourth Framework.

assistant: **Concept**

Pressure vessels are used in many industrial fields, for instance refineries, chemical, petro-chemical, biotechnological and cryogenic industries. The safety of vessel exploitation demands qualification tests which are, at present, hydraulic tests. Every pressure vessel has to undergo these qualification tests both at the final acceptance stage before its first usage and on a periodic basis during its life span. The advantage of the regulatory hydraulic proof test is that it verifies whether the pressure vessel is capable of withstanding the maximum service pressure. However it is costly and still gives little information about the integrity of the structure. In particular, it cannot detect the presence of evolving defects. In certain cases there is a risk, firstly of causing defects which will evolve without being detected and, secondly, of affecting the performance of the vessel with ice formation and corrosion as a result of the moisture that remains. Pneumatic tests of vessels is a way to overcome these difficulties, but could be widely used and specified in regulations only when the safety of such tests can be guarantied. The aim of the project is to develop and validate a real time surveillance method to ensure the safety of pneumatic tests on pressure vessels, using Acoustic Emission measurements (A.E.). This surveillance method will enable a decision to be made as to whether vessel pressurization should continue or be stopped when changes affecting a defect of a dangerous nature are detected and located. The real time decision of the detection of an evolving defect and the eventual stopping of the vessel pressurization will be supported by a system based on a neural network. The method will answer to industrial specifications for pressurisation tests (security r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The potential of the chlorophyll fluorescence for the retrieval of the oceanic constituents in Mediterranean coastal waters using spaceborne ocean colour measurements' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

In the frame of the COASTIOOC (l) project which is currently being initiated by a number of European research institutions, I intend to study the potential of chlorophyll fluorescence measurements for the retrieval of the oceanic constituents in Mediterranean coastal waters from spaceborne measurements. My work will follow three steps. First, I will validate the fluorescence scheme of an existing radiative transfer model. For this purpose, I will use measurements performed at the host institution (LPCM, Villefranche-sur-Mer, France) by A. Morel and his group.The validated model will then be used to generate a synthetic data set of in-water, water leaving and top-of-atmosphere radiance spectra for the range of oceanic and atmospheric states encountered in the coastal areas of the Mediterranean Sea. This data set will finally be used to investigate the potential of chlorophyll fluorescence measurements for the retrieval of phytoplankton in the presence of other optically active oceanic constituents (mineralic particles, dissolved organic matter, detritus) using simulated neural networks for the inverse modelling. (1) COASTIOOC = Coastal Surveillance through Observation of Ocean Colour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Synthetic Molecule that can Walk down a Track!' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Nature’s conversion of chemical energy into directed molecular motion has inspired the design of many synthetic molecular architectures aimed at performing function on the molecular scale.  Synthesis of small molecule analogues of these much more intricate biological systems may allow man to model the efficiency, and possibly develop processes that parallel the effectiveness of energy transfer in natural systems.  The proposed research outlines the synthesis and operation of a synthetic “walker” and “track” conjugate, which is designed to result in synthetic molecular processive motion induced by appropriate stimuli, much like that of Kinesin and Dynein which are linear motor proteins (driven by ATP hydrolysis) that engage in processive motion intracellularly .  Organic synthesis of the components and self-assembly of the conjugates by transition metal coordination chemistry will gain us access to the desired synthetic targets.  Invoking stimuli responsive molecular movement of the “molecular walker” component along the “molecular track” component will be achieved by exploiting the ligand-coordinate bond with various acid/base and oxidation/reduction states,  while progress of the “walker” moving along the “track” will be monitored by NMR, MS, UV-Vis, and FRET.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accurate cell signatures for the advancement of personalized medicine' (Cellphmed) under Horizon 2020.

assistant: **Objectives**

Patient/individual specific cells, including induced pluripotent stem (iPS) cells will be crucial in defining tomorrow’s medicine owing to their uses in drug discovery, immunotherapy or cell therapy. These clinical applications require the utmost accurate and reliable identity and purity testing, however, the majority of cells stored worldwide fall short of a sufficient level of characterisation. This project aims at validatating and commercializing an innovative method of diagnostic and quality control for human cells. It is based on our unprecedented ability to measure the expression of millions of uncharted RNA biomarkers called TEs, genetic units that contribute over 50% of the genome but that have been completely disregarded until very recently, mainly due to the challenge imposed by their complex analysis. Our new methodology provides a high-density barcode of cellular identity, opening the door for individual-specific cells to broad applications in biotechnology and medicine alike.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ICT Infrastructure for Connected and Automated Road Transport' (ICT4CART) targeting Horizon 2020.

assistant: **Abstract**

ICT4CART, totally aligned with the work programme, is providing an ICT infrastructure to enable the transition towards road transport automation. To meet this high level objective ICT4CART is bringing together, adapting and improving technological advances from different industries, mainly telecom, automotive and IT. It adopts a hybrid communication approach where all the major wireless technologies, i.e. cellular, ITS G5 and LTE-V, are integrated under a flexible “sliced” network architecture. This architecture will ensure performance and resilience for different groups of applications according to the needs of higher levels of automation (L3 & L4). On top of that, a distributed IT environment for data aggregation and analytics will be implemented. This offers seamless integration and exchange of data and services between all the different actors, allowing 3rd parties to develop, deliver and provide innovative services, thus creating new business opportunities. Cyber-security and data privacy aspects will be duly considered throughout the whole ICT infrastructure. In addition, novel accurate localisation services, exploiting the cellular network and information from other sources, such as on-board sensors, especially in complex areas (e.g. urban), will be addressed. Standardisation and interoperability are of high interest within ICT4CART in order to ensure the impact of the project towards enabling the transition to higher levels of automation. In this context issues related to the frequency spectrum will be investigated, while through the organisation of relevant workshops the engagement of policy makers and public authorities is ensured. To achieve its objectives ICT4CART, instead of working in generic solutions with questionable impact, it builds on four specific h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Unconventional Bifunctional Catalysts'.

assistant: **Concept**

The development of sustainable chemical processes is one of the most important features in modern chemistry. It has become a key research area worldwide providing solutions to important societal demands by optimizing the use of natural resources and minimizing waste and environmental impact. Among the relevant methods for achieving this goal, catalysis represents a key and central approach. Both Organocatalysis and Metal Catalysis have emerged as solutions to the problems in this context. In this field, the progress of a novel bifunctional organocatalyst that could increase the number of different activations, and therefore the synthesis of valuable enantio-enriched molecules, would be highly desirable. Especially important, but still unknown, are the bifunctional-catalysts based on a Neutral Coordinate Organocatalyst and Photo-Organocatalysts. This proposal aims to develop two new unconventional approaches for the synthesis of bifunctional organocatalysts.The first one is based on the development of new Bifunctional Neutral Coordinate Organocatalyst and their application to the synthesis of biologically relevant compounds. I propose to use these bifunctional catalysts to promote the dual activation of silyl reagents and suitable electrophiles. This approach constitutes an unconventional way to synthesize asymmetric molecules and has no precedent in the literature.The second section of this proposal explores the photo-activation-bifunctional organocatalyst. I propose the design and application of new metal-free Bifunctional Photo-Organocatalysts which are able to chemically and photo-activate the substrate simultaneously in an asymmetric manner. This project has the potential to change the general view of asymmetric Neutral Coordinate Organocatalyst and Photo-catalysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flow Control: Reduced Order Modelling, Nonlinear Analysis and Control Design' under Seventh Framework.

assistant: **Concept**

Fluid flow, i.e. the motion of liquids or gases, is a phenomenon that one encounters continuously in everyday life. The flow of air around the body of a car or the wing of an aircraft, the motion of petroleum through pipelines, flow of water in oceans and the motion of the clouds are only a few examples of fluid flows. Flow control refers to the ability to manipulate fluid flow to achieve a desired change in its behaviour. Flow control is very important from a technological point of view and offers many potential benefits, such as reducing fuel costs for land, air and sea vehicles, and improving effectiveness of industrial processes. Although this potential impact had been understood for a long time, the interest and funding on the topic had been modest, due to technological and economical difficulties regarding its implementation. The situation turned around dramatically with the recent advances on sensors, actuation and computing, as a result of which flow control today is more practical and economical than ever. EU’s strong interest to explore this direction is also indicated by its relevance to a high number of objectives within the FP7 Cooperation Programme, under the Transport (including Aeronautics) theme, Energy, Space and Security Themes. The project proposed aims at improving the state of the art in flow control through two main directions identified through the researcher’s past experience and research efforts in the field, namely: reduced order models amenable to control design and, nonlinear analysis and control design techniques. The research in the proposed project will investigate these directions through developing original and innovative methods that stem from the researcher’s earlier promising results. These methods have the potential of bringing a wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hemozoin Detection using Nitrogen-Vacancy centers in Diamond' (HEMOTECT).

assistant: **Concept**

Advances in chemistry, biology and medicine have been historically promoted by physical tools, with notable examples x-ray crystallography, nuclear magnetic resonance spectroscopy and microscopy. A new physical tool has recently emerged as a unique electromagnetic-field sensor and it is based on the exploitation of the remarkable magneto-optic properties of one particular color center in diamond, known as the Nitrogen-Vanancy (NV) center. In recent years, nano-scale sensors using NV centers have enabled the detection of nanoscale ensembles of nuclear and/or electron spins, and high-resolution imaging of living cells, to name few of the most outstanding sensing demonstrations using NV centers. We propose the development and implementation of a high-throughput sensor utilizing NV centers in diamonds, for the sensitive, quantitative and rapid detection of ensembles of paramagnetic spins in liquids and crystals. Sensitive paramagnetic-spin sensors will enable the possibility for nanoscale sensing and imaging of the structure and electron configuration of biomolecules, and most importantly, of real-time observations of chemical and biological processes. The principal motivation for the proposed project is the implementation of the developed sensor for the detection of paramagnetic crystals, and in particular of synthetic hemozoin crystals. Synthetic hemozoin crystals have identical magneto-optic properties with naturally-grown hemozoin crystals, a byproduct of malaria infection. A label-free, high-throughput sensor of hemozoin crystals, with sensitivity limits better than the currently used malaria diagnostic techniques will pave the way for a new diagnostic tool that could be used for the early diagnosis of malaria, and therefore, contribute to the eradication of one of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fighting Anxiety with Importin-based Therapeutics' in the context of a Horizon 2020 call.

assistant: **Objectives**

Anxiety and stress-related conditions represent a significant health burden in modern society. Anxiety disorders are currently treated with a variety of agents targeting synaptic mechanisms. These agents either directly affect neurotransmitter receptor systems or modulate neurotransmitter levels or availability, but their long-term use is limited by problematic side effects and suboptimal efficacy. The development of new anxiolytic drugs has been fraught with difficulty, hence there is a need for new targets and new avenues for therapeutic development.Importin-dependent transport mechanisms link synapse to nucleus in a diversity of physiological contexts, rendering them potentially interesting targets for behavioural control. However importins and related molecules have not been evaluated for roles in anxiolysis to date. We discovered the roles of importins in axonal injury signaling and in cell size sensing. During the course of our current ERC Advanced grant, and as part of one of the aims, we have conducted comprehensive phenotyping of importin mouse mutants to identify in vivo consequences of the deregulation of size control pathways. One importin mutant line presented a specific phenotype in anxiety tests, and follow-up analyses identified a new molecular pathway for anxiety regulation, and approved drugs affecting this pathway that can be repositioned for anxiety treatment.In this PoC, we will (1) carry out IP protection on our initial identifications of anxiolytic drugs; (2) further validate the anxiolytic activities of these drugs and their closely related structural or functional analogs; and (3) devise an HTS-compatible assay for targeting the importin involved and conduct a pilot screen of ~200,000 compounds in this assay to identify new drug leads for anxiet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Oral and Written Language interactions'.

assistant: **Objectives**

The development of new technologies changes the ways we use language, constantly switching from oral to written language, when we text, talk on the phone, or write an email, making it timely to study language modalities and their interactions. Speaking and writing differ at least on the motor actions they require. Nonetheless, the cognitive processes leading to word selection are likely to be similar. Establishing precisely the specificities of speaking and writing in terms of cognitive, linguistic and motor processes, as well as neural pathways, remains to be accomplished. The aim of this project is to identify the commonalities and differences between language modalities, by looking at collaborative and competitive processes at play between modalities. This project takes advantage of a combination of cutting-edge behavioural, electrophysiological and neuroimaging techniques to tackle the questions at hand. First, I will evaluate the interaction between language modalities when learning the oral and written forms of novel words. Specific processes are in place during language acquisition, making it important to examine learning contexts separately. The originality of this study resides in investigating response execution mechanisms (e.g., spoken durations), and not only response initiation (e.g., reaction times). Second, I will evaluate the structural and dynamic interplay between language modalities at the neural level, combining electrophysiology and neuroimaging. By examining speaking and writing within the same experiments, this study aims to provide a more complete picture of language processing. This action will constitute an important body of knowledge relative to the modalities of language production, both during and after learning. Speaking and writing are cru
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Procedure for minimising the distortion while welding of thin sheet steels' in the context of a Fourth Framework call.

assistant: **Objectives**

The industrial and economic problem for producing companies is that product life cycles are shortened more and more because of the rapidly changing demands of the markets. Therefore, it is essential for the economical success of an enterprise to react fast to modifications of the market and to transfer the resulting demands into the product. Aim of the project is the development of a simulation technique which can predict the distortion which occur during welding because of an inhomogeneous stress situation. This will be evaluated exemplary for thin-walled metal steel plates and realised by finite element calculations. The main RTD goal is to minimise deviations from the aimed geometry in order to reduce the expenditure for the development of new products.