RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Engineered nanomaterial mechanisms of interactions with living systems and the environment: a universal framework for safe nanotechnology'.

assistant: **Objectives**

The NanoMILE project is conceived and led by an international elite of scientists from the EU and US with the aim to establish a fundamental understanding of the mechanisms of nanomaterial interactions with living systems and the environment, and uniquely to do so across the entire life cycle of nanomaterials and in a wide range of target species. Identification of critical properties (physico-chemical descriptors) that confer the ability to induce harm in biological systems is key to allowing these features to be avoided in nanomaterial production (“safety by design”).  Major shortfalls in the risk analysis process for nanomaterials are the fundamental lack of data on exposure levels and the environmental fate and transformation of nanomaterials, key issues that this proposal will address, including through the development of novel modelling approaches. A major deliverable of the project will be a framework for classification of nanomaterials according to their impacts, whether biological or environmental, by linking nanomaterial-biomolecule interactions across scales (sub-cellular to ecosystem) and establishing the specific biochemical mechanisms of interference (toxicity pathway).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Lithuanian Presidency Conference: Invest in Researchers. Better training and careers using new funding opportunities'.

assistant: **Innovation**

An EU presidency event will be organized with the objective to discuss the key factors impacting on the attractiveness of the researcher profession (with a special focus on young researchers) and how the measures proposed in the ERA framework can respond to these in the most effective way. The conference will be held on November 14 (the second half of the day) and November 15 (the first half of the day) at the Lithuanian Academy of Sciences in Vilnius.Up to 200 participants are expected. They will be the EU and national policy makers, opinion leaders and the stakeholders, including representatives of funding organizations, early stage and established researchers both in academic and non-academic sector, their employers, people from European professional and special interest associations of researchers, and social partners involved in developing, managing and using the human resources in R&D.The conference will provide a suitable forum for discussing issues related to the policy initiatives and actions at EU and national levels concerning the development of human resources in research and innovation, thereby contributing to the realization of the objectives of ERA. The conference will address the relevant topics from different perspectives while highlighting challenges and best practices. This conference will also encourage young people to embark on scientific careers.Dissemination of printed conference materials including an executive summary of deliberations and conclusions is foreseen for non-participating stakeholders who would likely use them for reference.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing and Implementing Sustainability-Based Solutions for Bio-Based Plastic Production and Use to Preserve Land and Sea Environmental Quality in Europe' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The project BIO-PLASTICS EUROPE addresses the topic „Sustainable solutions for bio-based plastics on land and sea“ (Topic identifier: CE-BG-06-2019), within the focus area „Connecting economic and environmental gains - the Circular Econonmy (CE)“ and will focus on sustainability strategies and solutions for bio-based products to support the Plastics Strategy. This shall include innovative product design and business models facilitating efficient reuse and recycling strategies and solutions, including ensuring the safety of recycled materials when used for toys or packaging food stuffs. In line with the EU strategy on international cooperation in research and innovation and in order to encourage the further replication, the European consortium is complemented by a partner in Malaysia, providing an added value and helping them to address the many problems they face.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Organic Mesocrystals: Formation and controlling of oriented nanoparticles of molecular solids for drug development' (OMECRY), addressing dissemination and exploitation.

assistant: **Impact**

The OMECRY research action aims to enhance the dissolution of pharmaceutical solids in the form of mesocrystals, i.e. to promote the drug development. I will also investigate the formation mechanisms of the organic mesocrystals, and influence of the different additives on these processes. The low dissolution rate and poor aqueous solubility of emerging new drug candidates limit the formulation approaches, clinical application, and marketability in pharmaceutical industry. The preparation of active pharmaceutical ingredients (APIs) in the form of mesocrystals can enhance the dissolution rate suitable for drug delivery. The voids between highly oriented nanocrystals and high surface area of hierarchical structure in the non-classical pathway of mesocrystals formation play a role in the process. Different additives can be used to control the self-assembly of particles so that avoiding mesocrystals fusion into single crystals. A suitable additive can be screened through density functional theory calculations. The microstructure of mesocrystals and its transformation and particle growth can be investigated through time-dependent experiments using SEM, TEM and laser diffraction particle size analyser. Computed Tomography will be used for the first time to obtain the density mapping of mesocrystals surface in phase contrast mode. The dissolution rates and solubility of the mesocrystals are characterized and compared to its single crystals. The feasibility of drug dissolution will be investigated through in vitro studies. Although many inorganic mesocrystals has prepared for photocatalysis, energy storage applications, formation APIs in mesocrystals is a new strategy which provides insights that are needed for further understanding of mesocrystals formations thereby improve its
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of CAE calculation methods and a concept for concurrent product development of injection moulded plastic components' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Injection moulded plastic components are in a increasing degree part of product development in nearly all lines of business. The undersigned injection moulders wish as soon as possible to improve our competitive power by developing a new concept for product development. This will be achieved by carrying out this proposed project. Today most product developments give us surprises caused by the difficulty in handling all the parameters and their complexity. The mistakes discovered after hard tooling and running-in are especially noticeable. There are approximately 15 categories of such mistakes, and they are unfortunately made again and again! The consequences of this are: a delayed release of product to the market, a poorer product quality, and larger part costs. These problems however represent new possibilities, if we can develop the necessary tools in cooperation with RTD-performers, in order to avoid these surprises. The goal of this project is to develop such tools, consisting of CAE calculation methods and a concept for concurrent product development. The project will have 8-12 SME participants in order to cover the field of the injection moulding process. Each partner will carry out at least one new product development in the project period and hereby contribute to the development and test of a new concept for product development. The following will be carried out at each participating SME during the project period: - test of the potential for reducing product development time; obtaining specified quality without large corrections; and reduction of part costs, - description of existing methods and ways of organising the development, - measurement of the result of the product development, - report of the measurements and of gained experience. As a parallel activity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'NanoBiCar: A novel immunotherapy for infectious diseases'.

assistant: **Innovation**

It is estimated that 20% of global mortality is associated with bacterial infections. The current treatment is based on the use of antibiotics, but nonspecific effects, difficulty in reaching intracellular bacteria, and the generation of antimicrobial resistance limit its effectiveness. Tuberculosis (TB) is the leading cause of mortality due to a single infectious agent: Mycobacterium tuberculosis (Mtb). Multidrug-resistant TB (MDR-TB) is a major threat to global health security. A quarter of the population is latently infected with Mtb, many of them MDR strains, so preventing new cases of this growing reservoir is a priority. Immunotherapy is an alternative option, but its effectiveness is based on the immune response capacity of a compromised host. NanoBiCar's long-term vision is to revolutionize the current treatment of bacterial infections with a groundbreaking and innovative immunotherapeutic approach, overcoming many of the problems associated with treatment, with potential application beyond this field. Using TB as a proof of concept, three immunotherapeutic platforms, using mRNAs encapsulated in lipid nanoparticles, not tested in bacterial diseases will be used to eliminate  intra (IC) and extracellular (EC) bacteria. These immunotherapeutic methods are safe, economical, accessible, ready-to-use, and specific, targeting latent/ acute/chronic infections, without generating resistance and suitable for use in high-burden, low-resource settings; effective regardless of the antibiotic resistance of the strain and its niche (IC or EC), the genetic background of the host and the degree of immunocompetence.


**Keywords:** tuberculosis, Infectious-diseases, Immunotherapy, mRNA-lipid-nanoparticles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Isometric actions' (ISOMETRIC).

assistant: **Innovation**

The increasingly demanding challenges in our society require the development of innovative ideas. These ideas often originate from mathematical models of phenomena in natural and life sciences, in medicine and business, in technology and engineering, in manufacturing and design, and in other areas. Many of these models lead to geometric structures describing the phenomena precisely or, in most cases, approximately. Innovation and scientific development depends upon a thorough understanding of these geometric structures.The aim of this project is to investigate geometric structures from the viewpoint of their symmetries, and to characterize them by some distinguished features. We are interested in the geometry of those submanifolds that arise as orbits of isometric actions on Riemannian manifolds. More precisely, we plan to investigate the following problems:- Classification of isometric actions on Riemannian manifolds. We will focus on polar and hyperpolar actions, or cohomogeneity one actions, that have attracted much attention over the last few years.- Study of the geometry of the orbits of isometric actions on Riemannian manifolds.- Characterization of the orbits of isometric actions by means of their geometric properties.The objectives of this proposal will be achieved by using techniques recently developed by the applicant and his previous host group and by developing a computer program of symbolic calculus, a matter in which the applicant is experienced.This proposal suits the objectives of the action: it promotes interdisciplinary relations (isometric actions have successfully been used for the construction and investigation of special structures which have substantial interest in physics; we use programming techniques to handle symbolic calculations), reinforces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'In situ 3D structures of viral replication complexes: cryo-electron tomography of enterovirus-infected cells' under Horizon 2020.

assistant: **Concept**

The aim of this study is to gain structural insights into the genome replication of human enteroviruses (EVs), specifically Coxsackievirus B3 which is the leading cause of viral myocarditis. EVs drastically reorganize the internal membranes of a cell within hours of infection, generating replication complexes (RCs), which are the sites of viral genome replication. Some molecular determinants of RC morphogenesis have been identified, and resin-embedding EM has indicated the drastic membrane remodeling involved in RC formation. However, such approaches fail to reveal the macromolecular structural organization of RCs in cells. To further our understanding of RC assembly and activity, I propose to use cryo-electron tomography (cryo-ET) to determine 3D structures of enteroviral RCs in infected cells. Human cells will be infected on EM grids and the recently developed cryo-focused ion beam milling technology will be used to make RCs inside infected cells accessible to structural studies using cryo-ET. The determined structures will reveal the supramolecular organization of viral proteins and RNA at EV RCs. The findings will clarify the long-standing question regarding the relation between membrane topology and the RNA synthesis machinery. Subtomogram averaging methods will be used to reveal how the viral polymerase assembles into higher-order structures on the RCs membrane, and obtain high resolution structures of these assemblies. Assemblies of purified EV polymerases will be imaged by cryo-ET and compared to structures found in cells. Additionally, the effect on the Golgi apparatus of the viral proteins thought to initiate the membrane remodelling will be studied by cryo-ET. Taken together, this project will determine the first high-resolution structures of viral RCs in cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Consumer oriented solids transport technology' (COSTT), addressing dissemination and exploitation.

assistant: **Impact**

Caking or solidification of solid products during transport or storage is an expensive burden on the European Chemical Industry and adds costs to the user. The project was identified as a critical industrial need by the SPIN Thematic Network and aims to develop a scientific understanding of caking, which will supersede current time consuming and wasteful empirical methods. Project deliverables will be: the knowledge of what mechanisms and fundamental particle properties are responsible for caking behaviour; which material properties can be exploited to generate anti-caking agents a software tool for the prediction of caking and the ability to select specific anti-caking agents for particular products. This should lead to reduced supply chain costs, a faster time to market, improved quality of products and therefore improve the competitiveness of the European Chemical industry in the global market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A new system for the rapid isolation and safe incubation of tuberculosis' (1994-1998).

assistant: **Innovation**

The World Health Organisation has declared tuberculosis a Global Emergency, and has forecast that over 30,00,000 people will die of the disease in the next decade. TB is highly infectious and it is estimated that over 25% of new cases arise as a result of incorrect diagnosis. With fast, accurate diagnosis and correct and timely drug therapy, the disease can be treated, and lives can be saved. Current diagnostic methods are expensive, slow or grossly inaccurate. The WHO has set the year 2000 as the target date for the diagnostic industry to develop and introduce a new diagnostic test that is accurate, rapid, low cost, robust, and simple and safe to use. No currently available method fully meets these criteria. Such a test would be particularly suited to the needs of the low-income countries of the world where the problem of TB is generally most acute. Our project seeks to develop a safe, rapid method of accurate TB diagnosis, that would have wide application in the developed and developing countries throughout the world, and will meet the challenging target set by the WHO. Safety is achieved by enclosing the specially configured diagnostic test in a self-contained category 3 workstation. Our proposed methodology is highly innovative and is based on the development of a novel assay that makes use of bacterio-phage with a specific affinity to Mycol bacterium tuberculosis, a selective virucide, and specially selected helper bacteria", to detect very rapidly the presence of low numbers of the target bacteria in patient samples. This assay will allow a complete analysis of a day's throughput of prepared samples to be fully contained within a unique workstation and provide maximum operator protection against infection from the samples during the assay process. The integrated d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Security Assurance FramEwoRk for neTworked vEhicular teChnology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The assurance of security, privacy, reliability and safety features is key-point to unlock the enormous potential that the connected vehicles systems paradigm i.e., the dynamic Cyberphysical system of highly-equipped infrastructure-connected vehicles with numerous third-party components, can offer towards safer transportation. The emerging systems expose a variety of wireless-communication and hardware interfaces which result in a large attack surface; thus, attempts to assess the degree of confidence that security needs are satisfied come with prohibited cost for automotive stakeholders and OEMs.SAFERtec project will leverage a highly-skilled consortium to first model the varying exposure of a prototype connected vehicle system to numerous threats appearing under two generic instances of the increasingly pervasive V2I setting. One relates to road-side unit communication while the other involves the interaction with cloud application and passengers' smart devices. Then, adopting a systematic vertical approach SAFERtec will obtain an in-depth look of the possible vulnerabilities performing penetration-testing on individual hardware components and upper-layer V2I applications. Considering the available security mechanisms a third party provider already applies to each module, SAFERtec will determine a corresponding protection profile as a summary of the identified risks. An innovative framework appropriately designed for unified and thus, cost-effective use across all modules will employ statistical tools and security metrics to quantify the involved security assurance levels and also feed the incomplete automotive standards. Research on dependability methods will then allow the framework's transition from individual modules to the connected vehicle system. All above resu