RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular Regulation of Dendritic Tree Formation during Neocortical Development' under Seventh Framework.

assistant: **Concept**

This grant would support the establishment of a dynamic research group in the field of molecular neurobiology at the Karolinska Institute in Stockholm. The PI is a Portuguese national with a PhD from the University of London, and is currently a junior team leader at the Charité Medical University, Berlin.The group analyses the molecular regulation of neuronal dendritic tree formation during early development of the mouse neocortex. The neocortex is the region of the brain required for complex tasks such as thought and decision-making. Neocortical neurons have highly elaborate branched dendritic trees containing small protrusions called spines that are the main site of information input to the neuron. Defects in the formation of the dendritic tree are at the base of most viable neurodevelopmental disorders, including mental retardation and autism spectrum disorders (ASDs). Unfortunately, very little is known about the molecular mechanisms that regulate formation of the dendritic tree during normal or abnormal development.The aim of this project is to analyze the role of new players we recently identified, in promoting dendritic tree branching and spine formation in the mammalian neocortex. In particular, we will analyse novel roles of NOMA-GAP, a protein that triggers neocortical dendritic development (Rosario et al. Genes Dev 2012), and newly identified binding partners in directing these processes during brain development. Our approach combines the use of transgenic mouse models, primary neuronal cultures and in vivo manipulation of signalling pathways in the mouse by in utero electroporation, as well as analysis of mouse behaviour. This powerful combination of techniques will allow us to identify novel signalling pathways involved in brain development and to link thes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cervical cancer detection platform based on novel laser processing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

About 10% of all cancers diagnosed in women worldwide, are cancers of the cervix, the organ that connects the uterus and the vagina. Alone in the European Union over 16,000 deaths are reported annually due to cervical cancer effecting women mainly between the ages of 25 and 50.Within the scope of this fellowship, hosted by Dublin City University (Ireland) in collaboration with Arrows Biomedical GMBH (Germany), a highly sensitive platform to detect Human Papillomavirus (HPV), causative agent of about 99.7% of cervical cancer, will be developed. The proposed diagnostic platform will be based on a laser textured biopolymer as device substrate, functionalized with nanoparticles produced via the Pulsed Laser Ablation in Liquid (PLAL) technique. This on-chip immunoassay will allow rapid detection of the HPV. The novelty of this project lies in the high-quality bio-nanostructures as nano-labels via PLAL designed for ultrasensitive detection of HPV. Two major aspects of this project are: (1) the development of complex nano-labels specifically targeting high risk HPV; and (2) improvement in the performance of the developed assay  increasing their sensitivity and specificity, relative to current start of the art. Ultrapure HPV-specific nano-labels will be prepared using pulsed laser ablation in liquid, a green synthesis route independent of any chemical processing. The proposed technique is advantageous due to the enhanced surface activity of laser-generated nanoparticles, which will reduce the amount of sample molecules needed for the successful detection by improving the limit of detection and overall detection time. This project aims at making substantial contribution to the advancement of cancer immunosensing based on a novel on-chip immunoassay design for medical application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'In Silico Clinically-Viable Assistive Tools for Prediction and Rehabilitation of Knee Osteoarthritis' (CARE-KNEEOA) targeting Horizon Europe.

assistant: **Abstract**

Knee osteoarthritis (KOA) is a leading cause of disability worldwide, with ~14% prevalence in Europeans aged over 40. KOA prevalence continues to rise, thus far, with no cure or proven prevention protocols. Nonetheless, an aberrant knee mechanobiological environment is known to accelerate KOA development. Tailored rehabilitation, aiming to favorably alter knee biomechanics and restore the joint, has shown great potential to postpone or decelerate KOA progression. But current rehabilitation protocols are based on indirect measures of knee biomechanics, often leading to suboptimal outcomes. Computational models have offered great potential for simulating knee mechanical response in functional activities, though none are developed in a holistic and individualized context. More importantly, they lack the prediction capability of tissue degeneration/regeneration to loading and the potential for clinical use, i.e., are not automated and fast and cannot use out-of-lab motion data. In this project, I will develop and validate highly personalized in silico tools to quantify knee cartilage mechanobiological degenerative/regenerative response geared towards out-of-lab and clinical use for predicting KOA progression in different functional activities, allowing personalized rehabilitation. The multiphysics computational models, assisted with artificial intelligence (AI), will be validated at different spatial scales using in vitro tissue and cell level experiments and in vivo joint loading and quantitative medical images. This multidisciplinary project bridges together complementary skill sets of Dr. Esrafilian, Profs. Korhonen’s and Delp’s teams, with their expertise in biomechanics, computational modeling, biochemistry, biology, and AI. The beyond state-of-the-art models of this r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Deep water, remotely operate, connection of pipelines from marginal offshore oil and gas into existing large diameter transmission pipelines' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Much of Europe's remaining offshore oil and gas reserves are in small marginal fields not connected tithe existing infrastructure of large diameter subset transmission pipelines. For efficient exploitation a method is required for connecting these fields, some of which are in deep water, into existing pipelines system. This project will develop a deepwater remotely operated system for connecting small diameter underwater pipelines into large diameter subset transmission pipelines. The system will operate without interrupting the flow, or reducing the pressure, of hydrocarbons inside the existing pipeline. Equipment exists for performing this type of operation (called Hot Tapping) onshore on low-pressure pipelines and in relativity shallow water with divers, in deep water or whilst maintaining bulwarking pressure on high-pressure subset pipelines. The project will develop, test and demonstrate a prototype system. New high-pressure sealing and cutting assemblies will be developed with the required deep water remote control and installation systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '8th conference on colloid chemistry' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The aim of the planned conference is to bring together colloid scientists, technologists and industrial experts from all over the world - especially from Europe - to discuss the broad spectrum of colloid science and technology. In order to reach that goal, leading experts have bee invited to cover novel trends in plenary and keynote lectures. In order to expedite the international participation - especially from Europe - we would like to sponsor the invited speakers, the participation of scientists from Eastern Europe and the participation of students mainly from Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Fragments of the Republican Roman Orators' (FRRO) under Seventh Framework.

assistant: **Objectives**

This project gathers together, edits and interprets the surviving evidence for the orators of the Roman Republican period whose speeches do not survive in complete form. Its scope includes material which is, or is preserved as if it is, the actual words spoken by Republican orators as well as material about occasions when men spoke, who their audiences were, and the kinds of arguments they used in order to persuade. Cicero is the only Republican orator whose speeches are transmitted in their entirety; the work of his predecessors and rivals is scattered across the surviving texts of antiquity. By making the fragments and testimonia of all Republican orators accessible to the scientific field, this project will transform our understanding of Roman public life, political ideology, and culture. The Project Team, based at the University of Glasgow and supported by an international Advisory Board, will i) prepare the edition of the fragments and testimonia ii) disseminate the findings of the project through a series of colloquia and a major international conference in 2015 iii) engage the scientific community with the project through invited colloquia and conference presentations and organised panels at other relevant conferences and scientific gatherings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Isolation and molecular and genetic characterization of glide/gcm target genes in drosophila melanogaster' under Fifth Framework.

assistant: **Concept**

The glide/gcm transcription factor induces gliogenesis by activating target genes that execute the glial differentiation program. Since glial differentiation depends on glide/gcm, I propose to identify and characterise its targets to determine the molecular cascade involved in gliogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Writing, reading and managing stress with H3K9me' to be submitted under Horizon 2020.

assistant: **Abstract**

Epigenetic inheritance is the transmission of information, generally in the form of DNA methylation or post-translational modifications on histones that regulate the availability of underlying genetic information for transcription. RNA itself feeds back to contribute to histone modification. Sequence accessibility is both a matter of folding the chromatin fibre to alter access to recognition motifs, and the local concentration of factors needed for efficient transcriptional initiation, elongation, termination or mRNA stability. In heterochromatin we find a subset of regulatory factors in carefully balanced concentrations that are maintained in part by the segregation of active and inactive domains. Histone H3 K9 methylation is key to this compartmentation. C. elegans provides an ideal system in which to study chromatin-based gene repression. We have demonstrated that histone H3 K9 methylation is the essential signal for the sequestration of heterochromatin at the nuclear envelope in C. elegans. The recognition of H3K9me1/2/3 by an inner nuclear envelope-bound chromodomain protein, CEC-4, actively sequesters heterochromatin in embryos, and contributes redundantly in adult tissues. Epiherigans has the ambitious goal to determine definitively what targets H3K9 methylation, and identify its physiological roles. We will examine how this mark contributes to the epigenetic recognition of repeat vs non-repeat sequence, and mediates a stress-induced response to oxidative damage. We will examine the link between these and the spatial clustering of heterochromatic domains. Epiherigans will develop an integrated approach to identify in vivo the factors that distinguish repeats from non-repeats, self from non-self within genomes and will examine how H3K9me contributes to a persisten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European development of orphan drugs' to be submitted under Fifth Framework.

assistant: **Abstract**

Orphan diseases are defined as disabling or life-threatening diseases, which incidence is below 5 p.10,000people. Some orphan drugs have been developed, mostly in the USA, thanks to the Orphan Drug Act. However, many of them have forsaken because of their low profitability and are still manufactured locally with regulatory status EDOD (European Development of Orphan Drugs) program intends to bring to the market orphan drugs with high medical need which have been forsaken by US firms. These drugs will be selected among products currently locally produced by Hospital Pharmacies and which fall within one the following therapeutic areas: clinical toxicology (antidotes), metabolic diseases or on co-haematology. EDOD aims at upgrading pharmaceutical and medical quality of these medications, and at harmonising at the European level access to these drugs by patients suffering from rare diseases. EDOD will bring together skills from 6 to 8 European SME's, so as to prepare European regulatory filing of 1 to2 drug candidates within 2 years. This will be the start of a longer co-operation between SME's on orphan drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Labour demand and gross worker turnover, how do they interact ? an empiricalanalysis of accessions and separations on individual data', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The labour demand of firms is measured by the net employment changes between t(0) and t(l), but they are accompanied by large worker inflows and outflows. The empirical specification of labour demand ought to include gross worker flows, in order to explicitly consider the heterogeneity of the labour force.  The final aim of this research field is to estimate a simultaneous mode of labour demand, wage supply, worker turnover. This research aims to enhance the understanding of gross worker flows, by studying accession and separation on individual data and linking them to job flows (via the vacancy chain) on aggregate data. This research will be set against its theoretical background, it will contain a survey of the main works on this topic, it will compare its results with similar empirical studies on other countries. Empirical estimates will be the core of the research: it will be carried out on a 1:90 random sample of workers of private Italian firms; this is a panel of 200,000 workers observed in 1985-1991 period.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Youth Citizenship in Divided Societies:  Between Cosmpolitanism, Nation, and Civil Society' to be submitted under Seventh Framework.

assistant: **Abstract**

YouCitizen is a comparative, multi-level ethnographic research project that examines the efforts of international organisations, civil society organisations, and states to foster citizenship for youth in divided societies.  In their efforts, agents working in such organisations often engage in paradoxical, if not contradictory, acts to promote both cosmopolitanism within civil society and national identities, even when aspects of national identity have been a source of division. A central premise of the research is that the outcomes of these efforts are conditioned by the contexts in which programmes for youth are delivered and enacted.  In these contexts – which include histories of division and marginalisation, societal and communal norms, family histories, and the spaces of daily life – youth interpret and experience citizenship. YouCitizen’s critical intervention is in extending the examination of citizenship formation to consider the ways in which youth interpret, experience, and potentially remake citizenship that is different to, and may actually challenge, the forms of citizenship that organisations and states attempt to instil.The empirical foci of the study are the networks of organisations promoting citizenship and/or civic engagement, and youth, aged 15-24 in South Africa, Bosnia-Herzegovina and Lebanon who have been involved with those programmes.  It explores the goals of those organisations, their funding sources and activities to understand both the vision of citizenship they promote and the traditions and influences from which they draw; particular attention is paid to ideals and values associated with cosmopolitanism vis-à-vis the nation and the ways in which they address social division.  Interviews and participant observation with youth explore the w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Safeguards in a world of AMbient Intelligence' (SWAMI) targeting Sixth Framework.

assistant: **Abstract**

This project aims to identify and analyse the social, economic, legal, technological and ethical issues related to identity, privacy and security in Ambient Intelligence (AmI), as called for in the Work Programme. The partners will review existing AmI projects, studies, scenarios and roadmaps to ensure that the SWAMI project captures, as far as possible, the major trends and issues. The partners will compose 'dark' scenarios, the aim of which will be to expose key socio-economic, legal, technological and ethical risks and vulnerabilities related to issues such as identity, privacy and security that may emerge from the deployment of AmI technologies and services, many if not most of which will be invisible to the public. The partners will define and study various research and policy options, which could serve as safeguards and privacy-enhancing mechanisms.The aim will be to identify mechanisms, which will ensure user control, user acceptance and enforceability of policy in an accessible manner, as well as to ensure that all Europeans have real equal rights and opportunities of accessibility to the Ambient Intelligence space. The partners will seek to validate their findings through two workshops with other AmI and IST experts before presenting the options to the Commission in a final report. Project results will be disseminated widely and continuously throughout the project and will be presented at a final, high-level conference.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Random Bifurcation Theory'.

assistant: **Objectives**

This project aims at developing the bifurcation theory of random dynamical systems in new directions beyond the traditional setting that are highly relevant in applied sciences. Despite huge developments in stochastic differential equations and their applications in both science and economics,  bifurcations in this context are only poorly understood, although qualitative changes in the behaviour of random dynamical systems are omnipresent due to nonlinearities. Research on bifurcations in random systems has flourished in the last decade, with main contributions on local bifurcations coming from the applicant and the host, as explained below. The proposed research builds upon these foundations to address not only open questions in local bifurcation theory, but also develop a fundamental theory for global bifurcations of random dynamical systems.


**Keywords:** Dynamical systems, Bifurcation theory, Random Dynamical Systems, Ergodic theory, Stochastic analysis