RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Physics, Accuracy and Machine Learning: Towards the next-generation of Molecular Potentials' under Horizon Europe.

assistant: **Concept**

Weak intermolecular interactions are the driving force of relevant processes including protein folding, charge transfer through solid state junctions in solar cells and collisions in interstellar gas clouds. Understanding the nature of these forces is essential to achieve better control and optimization of these processes. Nowadays, modelling has become an essential tool for unravelling experiments and aiding materials design. However, the accurate description of weak interactions is plenty of challenges for many theoretical approaches. Atomistic simulations can help decipher the mechanisms underlying complex processes nonetheless precise molecular potentials are required to achieve a quantitative and qualitative description of these physical-chemical processes. Despite the importance of this field, there is, at present, no systematic and comprehensive training in this subject, particularly in the fundamentals of the theory, method development, techniques to rigorously test the theory using experimental data, and the creation of new models using detailed physical understanding combined with machine-learning. The PHYMOL network aims to fill in this fill this gap by bringing together a group of experts in the field of chemical physics, intermolecular interactions, simulation and machine-learning with several industrial and academic partners. This program will exploit the synergies between an accurate description of intermolecular interactions and the use of machine learning techniques towards the generation of new molecular potentials. Combining scientific investigation with an intensive training program PHYMOL will help shape a new generation of researchers with the capability of developing accurate molecular potentials impacting a broad range of applications.


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'V-eliminator, innovative solution for varroa fighting' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Bees are critically important for the environment and to the economy. They ensure pollination for over 80% of crops and wild plants in Europe. It is estimated that pollinators, including honey bees, bumblebees and wild bees, contribute at least 22 billion EUR (265 billion annually worldwide), each year to the European agriculture industry.Yet in the past decades the number of bees in Europe has decreased by almost 25 %. Further decrease in bee population can therefore endanger the pollination. Besides the pesticides, one of the most important causes for decrease of bees is varroa.The main goal of the project is to develop a first laser based system for the mass elimination of varroa on honey bees. The laser used for removing varroa will offer much safer and more efficient solution to the varroa problem compared to existing solution.To reach TRL6 phase around 80 thousand EUR and 11 man/month (4 persons part time) of work has been invested. To accomplish the goal (TRL9), cca 900 thousand EUR and two years of work is needed, 8,5 persons full time.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Overdominance: from spontaneous mutations to balancing selection in natural populations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Overdominance occurs when individuals carrying two different alleles at a specific locus have higher Darwinian fitness than both homozygotes, who carry only one allele. It is involved in a range of observations in genetics and evolution (e.g. genetic diversity, inbreeding depression, heterosis)  and has been controversial for over a century. Empirical studies on the frequency of spontaneous mutations causing overdominance are scarce and there has been no systematic effort to screen for overdominant alleles in any natural population. We propose to (1) test a recent theory predicting that the rate of spontaneous mutations with overdominant effect on fitness increases with maladaptation, and (2) screen for overdominance alleles in a natural population. We propose to use the most appropriate model system for answering each of these questions: Saccharomyces yeast for spontaneous mutations, and Daphnia for segregating alleles. Cutting-edge methods in experimental evolution and quantitative genetics will be used. This project will contribute to the scientific competitiveness of Europe by strengthening a new area of research in France (the scientist in charge will maintain permanent projects using experimental evolution with yeast), providing large libraries of yeast and Daphnia genotypes, and producing high-impact publications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From microns to reefs: mechanistic insights into coral biomineralisation and the fate of coral reefs' (Microns2Reefs).

assistant: **Concept**

Coral Reefs are under threat from climate change, pollution and other local and global anthropogenic disturbances. Microns2Reefs will go beyond the state of the art by providing the mechanistic understanding needed to accurately predict their fate given the multifaceted and multifactorial anthropogenic threats they face. Coral reefs provide many ecosystem functions, from coastal defence to sustaining fisheries. These, and many others, critically depend on the 3D framework of the reef made from the skeletons of Scleractinian corals. The coral biomineralisation tool kit is known but key questions remain: what biomineralisation tools are most important? what and how do environmental and biological factors limit and influence biomineralisation? how does the environmental sensitivity of coral biomineralisation determine the diversity, resilience, and survivability of individual colonies and the entire reef? The answers to these questions are key to inform the strategies needed to effectively manage these diversity hotspots and are placed into sharp focus by recent coral mass mortality events and the rapidity of anthropogenic climate change.Microns2Reefs will produce a step change by integrating a raft of new and innovative scientific techniques to provide a mechanistic understanding of coral biomineralisation and hence coral reef resilience. Microns2Reefs has four objectives: 1) to develop a novel multimodal imaging technique to reconstruct the nature of the calcifying fluid and the biomineralisation process in 3D; 2) use this to build a detailed model of coral biomineralisation; 3) develop a mechanistic understanding of the relationship between environment and skeleton construction; 4) quantify the future resilience of corals and coral reefs in the face of multiple anthropo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'The potential and application of virus host evasion genes that modify apoptosis and cytokine responses'.

assistant: **Objectives**

The aim is to identify and exploit viral modifiers of apoptosis and cytokine responses (particularly Toners) as a potential source of novel health care pharmaceuticals for manipulation of immune responses and treatment of certain diseases. Such virus genes will be identified by nucleotide sequence and functional analysis of cloned viral Orbs and coda libraries of three large DNA viruses (African swine fever, Extremely and Mouse herpes). Possible human homologue of novel sequences will be characterised. The cellular targets of these viral evasion genes and their impact on apoptosis and virus pathogenesis will be determined. Determination of minimal active sequences will permit the development of low molecular weight peptide drugs, starting with the calcineurin phosphates inhibitor A238L gene of ASFV.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Exploring the Impacts of Global Change on the Risk of Aedes and Dengue Expansion in Tanzania'.

assistant: **Objectives**

Dengue, a vector-borne disease transmitted by Aedes mosquitoes, has emerged as a significant global health challenge, particularly in regions like East Africa, where its impact is increasingly felt. Tanzania, with recurrent outbreaks and an expanding range of mosquito vectors, offers a critical case study for understanding dengue's broader epidemiological trends in these regions. The spread of Aedes aegypti, driven by global changes such as rising temperatures, urbanisation, and increased transportation networks, has intensified the threat of dengue in Tanzania. Despite this, substantial knowledge gaps remain, particularly in predicting future hotspots for transmission and understanding the extent of the population at risk, now and in the future.The TRACED project aims to address these gaps by integrating innovative methodologies to assess ecological niches, human population dynamics, and dengue transmission risk. The project's outcomes are expected to support global efforts to achieve Sustainable Development Goal (SDG) 3.3, which focuses on ensuring healthy lives and promoting well-being for all, by raising awareness among policymakers, which is crucial for effective intervention strategies. Given the limited research and funding in this area, particularly in Africa, this project will provide critical insights and methodological frameworks that can be applied across resource-limited regions, contributing to better preparedness and response to future dengue outbreaks.Researchers from Technological University Dublin and the Institute of Tropical Medicine are collaborating with Tanzania's Ministry of Health's Neglected Tropical Disease programme and local experts from the Sokoine University of Agriculture (SUA), the Nelson Mandela African Institution of Science and Techno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Environmental Policy Integration and Multi-level Governance'.

assistant: **Objectives**

The integration of environmental issues into other policy areas (EPI) is widely recognised as key for sustainable development (SD). It is also the biggest challenge facing the environmental community, requiring not only a new approach to policymaking but also changes in policies and their implementation. However, the crosscutting nature of EPI does not easily fit with traditional hierarchical governance based on (nation) state authority, sectoral differentiation, and 'command and control' type instruments. It is therefore not surprising that measures to promote EPI frequently also rely on new modes of governance, such as voluntary, procedural, information, learning and market based instruments.Efforts to achieve and improve EPI are currently being made at local/regional, national, European and global levels of governance, and within the private sector. Measures at different levels may affect each other, thereby improving or weakening EPI and SD. Indeed, the interlinkages between these different modes of governance and layers are emerging as a central challenge in the area of EPI. There is a rapidly growing body of literature analysing and discussing different EPI approaches and measures.The CA aims to structure these findings and to identify avenues for future research by focussing on two main themes: First, is it possible to identify modes of governance, which are typically used to promote EPI at particular levels, eg. local/regional, national, EU, global? If so, which governance modes are typically used at which levels? And which are most effective or show most promise? Second, how do EPI measures at the different levels affect each other and how could governance be improved to increase synergies and minimise negative interaction effects across the levels? Assembling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Unexplained cardiac arrest registry of Europe. The molecular counterpart'.

assistant: **Objectives**

Objectives:1) To identify, within the patients survived to an episode of Idiopathic Ventricular Fibrillation (IVF), those who may not require an automatic Implantable Cardioverter Defibrillator because a treatable disease has been identified by a molecular approach. 2) To further define the true IVF population by excluding those patients in whom this novel approach allows the diagnosis of a definite disease. 3) To attempt the genetic characterisation, and possibly the identification of the gene, of the so called Brugada's syndrome" which is currently included in the diagnosis of IVF. 4) To continue the successful experience of UCARE, the Unexplained Cardiac Arrest Registry of Europe, in order to provide definitive information on the natural history and on the long term effect of therapy in IVF patients.Brief description:Cases of IVF will be referred by any physician willing to comply with the enrolment and follow up procedures. Data on individual patients are collected on standardised forms, specifically: a) Enrolment, b) Follow-up and c) Terminal event/change of diagnosis. Each individual enrolled is requested to have a follow-up visit every year or whenever an arrhythmic event occurs.For each patient blood (20 ml) will be collected in heparin for implementation of lymphoblastoid cell lines that will provide a continuous source of DNA for the present as well as future studies on IVF. Myocardial biopsy is already routinely performed in 70% of the IVF patients and it is evaluated by conventional histopathology. Paraffin embedded slices will be used for DNA extraction. DNA is isolated from immortalised cells lines of lymphoblasts. A fraction of extracted DNA will be stored at -20°C and will represent a DNA bank for IVF survivors. Identified genes associated to Long QT Syn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms and Functions of Brain- Body- Environment Interactions in C. elegans' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Recent large-scaRecent large-scale neuronal activity recordings in awake, behaving animals revealed a new, unexpected neuroscientific principle: widespread neuronal activity patterns across the brain encode parameters of movement. Surprisingly, these brain-wide behavior representations even extend to areas that are implicated in the processing of sensory information (e.g., the visual cortex in mice). Thus, a large fraction of the brains activity seems to be dedicated to representing the animals current, ongoing behavior. These observations have been made across the animal kingdom including worms, flies and mammals, suggesting a universal principle; however, the underlying mechanisms and functions remain unknown. In this proposal, we take advantage of the tractable model organism C. elegans to tackle this problem, combining brain-wide single cell resolution Ca2+-imaging in freely behaving animals with genetic circuit manipulation tools. It was previously recognized that the brain operates in a closed loop, actively sensing its body and its environment and making predictions of movement outcomes to optimally control behavior. Here, we propose to reconcile these long-standing concepts with the new observations of brain-wide behavior representations. Our core hypothesis is that sensory to motor transformation is a distributed process incorporating multiple functions like gain-control, re-afference prediction and predictive processing. Our team is at the forefront of scientific innovation and discoveries in this field, and we thereby are making substantial contributions to this currently ongoing paradigm shift in our understanding of how the brain operates. Studying these phenomena in worms offers a unique and timely opportunity to rapidly uncover the universal functions of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multipurpose regional reference network systems for positioning and navigating with the use of satellites' under Fourth Framework.

assistant: **Concept**

The scientific and technical objectives of this research proposal concern the development, testing and improving of a comprehensive regional network system of reference stations, supporting a wide range of position and navigation activities with the use of satellites (GPS). The aim is to enable one-man operation for all GPS positioning activities with improvement of accuracy and rapidity. Joint use of such a network system will substantially reduce the costs of positioning and navigation. Development of new GPS applications will be facilitated and increased. Research is required to define demands from various fields and to construct reference stations and a network that meet multipurpose specifications and European standards. Problems of general use of GPS and discrepancy of local coordinates are indicated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Detailed chemical kinetic models for cleaner internal combustion engines' under Seventh Framework.

assistant: **Concept**

The key objective of this project is to promote cleaner and more efficient combustion technologies through the development of theoretically grounded and more accurate chemical models. This is motivated by the fact that the current models which have been developed for the combustion of constituents of gasoline, kerosene, and diesel fuels do a reasonable job in predicting auto-ignition and flame propagation parameters, and the formation of the main regulated pollutants. However their success rate deteriorates sharply in the prediction of the formation of minor products (alkenes, dienes, aromatics, aldehydes) and soot nano-particles, which have a deleterious impact on both the environment and on human health. At the same time, despite an increasing emphasis in shifting from hydrocarbon fossil fuels to bio-fuels (particularly bioethanol and biodiesel), there is a great lack of chemical models for the combustion of oxygenated reactants. The main scientific focus will then be to enlarge and deepen the understanding of the reaction mechanisms and pathways associated with the combustion of an increased range of fuels (hydrocarbons and oxygenated compounds) and to elucidate the formation of a large number of hazardous minor pollutants. The core of the project is to describe at a fundamental level more accurately the reactive chemistry of minor pollutants within extensively validated detailed mechanisms for not only traditional fuels, but also innovative surrogates, describing the complex chemistry of new environmentally important bio-fuels. At the level of individual reactions rate constants, generalized rate constant classes and molecular data will be enhanced by using techniques based on quantum mechanics and on statistical mechanics.  Experimental data for validation will be