RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Large scale information extraction and integration \ninfrastructure for supporting financial decision making'.

assistant: **Innovation**

The FIRST project provides a large-scale information extraction and integration infrastructure that supports non-ICT skilled end users for on-demand financial information access and execution of financial market analyses. Innovations in FIRST are: information extraction from unreliable semi-structured sources on a massive scale and in near real-time; automatic reuse of existing ontologies, large-scale ontology learning, and advanced decision models making use of semantic attributes.<br/>The FIRST Decision Support Infrastructure enables end-users to configure, deploy, and execute financial decision models with associated information channels. The FIRST Ontology Infrastructure provides tools for semi-automatically creating and maintaining domain knowledge models. The FIRST Semantic Information Extraction System addresses noise, uncertainty, and semantic interpretation of information sources. The FIRST Information Integration Infrastructure consolidates information from very large heterogeneous information sources.<br/>FIRST validates its innovations by three complementary use cases of market surveillance, investment management, and online retail banking and brokerage. The consortium comprises for each solution providers, data sources, and end users. FIRST implements a systematic strategy for scaling its methods and software infrastructure to the processing of massive amounts of information in real-time by three steps: (1) functional prototype, (2) scaling for non time-critical processing of massive historical data, and (3) scaling for massive live streams of structured feeds, textual news wire feeds, as well as semi-structured Web information in real-time.<br/>The impact is ensured through an active open source strategy which (1) bases all basic software components in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'New generation of HVDC insulation materials, cables and systems'.

assistant: **Innovation**

The overall objective of NEWGEN is to develop and demonstrate new insulation materials, cable manufacturing solutions, online condition monitoring technologies, and comprehensive life and reliability modelling tools for the next-generation of extruded HVDC cables and cable systems, thereby fostering the reliability and resilience of the inter-connected European HVAC/-DC transmission grids. NEWGEN delivers new space charge mitigating additives for extruded HVDC insulation materials, as well as new industrial cable extrusion solutions for defect-free and cost-effective manufacturing of next generation thermoplastic HVDC cables. Moreover, NEWGEN will provide online global condition monitoring and novel pre-fault detection methods and instruments for assessing the health status of extruded HVDC cable systems, as well as comprehensive tools and models for the evaluation of life and reliability of extruded HVDC cable systems (cable, joints and terminations) under realistic operation conditions within HVAC/-DC grids (model demonstration via grid-simulations). The new sustainable insulation materials and extrusion solutions will contribute to improved dielectric performance and reliability of extruded insulations needed for reaching TRL maturity for higher rated voltages up to ±600 kV. The uniqueness of the NEWGEN concept is that it is not limited to any specific insulation compound or HV cable manufacturer, but rather the results will impact the whole European HV cable industry for reaching the next generation of reliable-by-design extruded HVDC cables. Moreover, the NEWGEN innovations for online condition monitoring and reliability modelling of HVDC cable systems will allow European transmission system operators (TSOs) to perform comprehensive monitoring and proactive mainten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SIngle-cell multi-OMICs approach to study intra-tumour heterogeneity of soft tissue Sarcomas' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Recently, multi-omics approaches have led to a plethora of publications describing in detail the ‘omics landscapes of common cancer types. However, at the bulk tissue level, integrating different ‘omics layers remains an uncompleted challenge. Soft tissue sarcomas are rare and often aggressive cancers of mesenchymal origin representing ~1% of all cancers but encompassing at least 50 subtypes. Hence, collecting enough of these rare samples for significant findings in a timely fashion is the biggest hurdle. This issue can be addressed by repeating observations within individual patients to generate new hypotheses. Our long-term collaboration aims to obtain the genome, transcriptome and methylome of each of 1,000 single-cells from 10 individual subtypes of soft tissue sarcomas. This design is possible thanks to DNA & RNA single-cell sequencing (SCS) of the same cell in Dr. Voet’s lab, and bespoke computational analyses in Dr. Van Loo’s lab, and access to this rare material of Prof. Flanagan, lead for the sarcoma component of the Genomics England 100,000 Genomes Project. This proposal is the pilot project, where we focus on one malignant peripheral nerve sheath tumour, a rare aggressive cancer originating from the connective tissues surrounding nerves. We will also sequence multiple regions of the primary tumour, the blood, and cell-free tumour DNA (ctDNA) before surgery and subsequently every three months. Prof. Flanagan’s group will process the samples, and Dr. Voet will oversee the sequencing. In Dr. Van Loo’s lab, I will develop the computational tools to uncover the 3 ‘omics signals at the single-cell level that are averaged out in bulk tissues. SCS will shed light on the fundamental links between cancer genomic subclones and the transcriptional and epigenetic diversit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification of new causative genes for congenital hypothyroidism' under Seventh Framework.

assistant: **Concept**

Congenital hypothyroidism (CH) is the most common neonatal metabolic disorder and, if untreated, results in severe neuro-developmental impairment and infertility. CH is genetically heterogeneous and causative genes identified so far account only for a minority of cases. Therefore many genes causing CH still remain unknown. This project aims to identify new causative genes for CH by combining autozygosity mapping and positional-candidate gene cloning strategies. For this purpose we have already assembled a large cohort of consanguineous families with CH and to achieve the goals of this project we plan to execute the following studies on the samples collected: i) the exclusion of known causative-loci by linkage analysis; ii) genome-wide linkage scan and autozygosity mapping studies for the determination of novel loci in families not linked to any known-locus; iii) direct sequencing and mutation analysis of novel candidate genes in newly mapped regions. State-of-the-art laboratory technologies such as high resolution SNP arrays and high-throughput sequencing will be exploited for the execution of tasks. Our initial results indicated that our cohort includes several families suitable for mapping novel loci and genes for CH. Identification of new CH genes through this study would enhance the diagnosis and classification of the disease and may provide novel insights into thyroid physiology as well as into molecular mechanisms underlying the disease. This in turn might lead to the development of new diagnostic and management strategies for hypothyroidism. This project meets a relatively new EU aim and focus to increase understanding of rare disease conditions with a potential of leading to new preventive approaches for these diseases. If supported, this fellowship will be a ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Global Viral Ecosystem Research and Preparedness Initiative' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The Global Viral Ecosystem Research and Preparedness Initiative (VERPI) is a comprehensive research programme addressing emerging infectious diseases through a One Health approach. VERPI project unites ten partners from eight countries across four continents — Europe, Asia, Africa, Northern America— to strengthen global research capacity for equitable pandemic preparedness. The VERPI scientific programme is structured around four main objectives 1. Strengthening capacity for pathogen discovery and characterisation 2. Accelerating countermeasures development: broad-spectrum antivirals, monoclonal antibodies and diagnostics 3. Enhancing biomarker discovery for viral pathogenesis and long-term health impacts 4. Leveraging community engagement to enhance public trust through transparent health communication. VERPI's innovative ""triple I"" —interdisciplinary, international, and intersectoral—framework leverages diverse expertise, transcends national boundaries, and bridges academic and clinical sectors. Central to VERPI's strategy are embedded secondments, fostering interdisciplinary collaboration and a dynamic approach to translational research in emerging viral epidemics. This promotes a broad R&I platform for rapid response to future viral threats, supporting EU Sustainable Development Goals to strengthen early warning systems and health risk management capacities globally.""


**Keywords:** Virology,  Pandemic-preparedness,  emerging infections,  antivirals,  Immunology,  Bioprofiling,  Pathogen Discovery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optical dissection of cortical dopamine signaling' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Coordination, execution and learning of skilled movements strongly depend on motor cortex function, which, in turn, depends on the modulatory action of different neurotransmitters. In particular, dopaminergic inputs to the motor cortex have been associated with synaptic plasticity, changes in cortical excitability and modulation of cortical motor maps. The integrity of dopaminergic terminals is required for the acquisition of novel motor tasks, but not for the performance of already learned ones. Despite evidence pointing to the importance of dopamine in the learning of novel motor skills, technical limitations have impeded solving several key questions. For instance, what are the exact behavioral conditions leading to dopamine release in the motor cortex during skill learning? Are dopamine fibers in the motor cortex synchronously activated affecting large cortical areas? Is dopamine necessary and/or sufficient for cortical motor learning? I will address these questions by combining my expertise in the field of dopamine signaling with the use of novel optical techniques recently developed by the European host institution and thereby dissect the role of dopamine with never-before-reached level of spatio-temporal accuracy. Specifically I aim to use in vivo two-photon imaging and optogenetic manipulations of genetically targeted dopamine axon terminals in the mouse motor cortex in combination with quantitative behavioral testing and characterize their role in the learning of novel motor skills. By recording and manipulating dopamine axon activity in the motor cortex I will test the hypothesis that dopamine acts as a necessary global signal of reward prediction error at the motor cortex level. This project will provide novel insights in the exact contribution of dopaminergi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dynamical Systems and Reaction Kinetics Networks' (DSYREKI) targeting Horizon Europe.

assistant: **Abstract**

The primary goal of the project is to advance the theory of dynamical systems governed by differential equations with multiple parameters, leveraging this enriched understanding to dissect mathematical models that mirror real-world phenomena and processes. Our exploration will span both qualitative and quantitative attributes of these systems, including their general structure, solution properties, bifurcations, stability etc. In a practical application of our theoretical insights and computational techniques, we will delve into the analysis of certain biochemical networks, with a focus on those integral to reaction kinetics. Employing a synergistic approach that melds symbolic and numerical computation, we aim to enhance the analysis of stability and bifurcations within intricate biochemical systems. This will be achieved by developing bespoke symbolic-numeric tools designed to uncover instances of multi-stability and bifurcations. Our qualitative and computational evaluations will serve dual purposes: elucidating established biological phenomena and forecasting emergent ones.Additionally, our research will extend to the  emphasizing parameter estimation and the resolution of control dilemmas for biomedical applications. We will explore novel territories of positive and impulsive control, areas currently lightly tread in existing literature.This project is inherently interdisciplinary, seeking to fuse and expand upon the methodologies from mathematics, applied mathematics and reaction kinetics, alongside the computational algorithms of symbolic computation. Incorporating the principles of the Green Charter, our research will also emphasize sustainable practices and the development of simulations aimed at addressing and mitigating environmental impacts associated with t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multimodal analysis of MR data using Bayesian methods' under Seventh Framework.

assistant: **Concept**

Through the development of this training-through-research project, the fellow expects to acquire new skills, knowledge and perspectives, as well as to develop and widen her competences significantly, all contributing to her career development. The purpose of this proposal is to acquire new research expertise in Bayesian methodologies applied to source identification in blind signal separation and applied also to fusion of different modalities of physiological measurements for tumour delineation in brain.Magnetic resonance (MR) is key for the non-invasive analysis of brain tumours in the field of neuro-oncology. MR imaging (MRI) provides a morphologic characterisation of tissues, while MR spectroscopy (MRS) provides their biochemical information, resulting in precise metabolomic signatures.  In this project, a multimodal MRI and MRS data analysis using Bayesian methods is proposed to address some medical questions that remain open, such as using additional knowledge to help extract better sources from the MR spectra, identify the exact number of underlying tissue types present in a sample and their spectroscopic patterns, and the use of them to track response to therapy. To address them, it will be necessary to solve some challenges from the methodological viewpoint, such as the extraction of relevant source signals in a multimodal (MRI and MRS) unsupervised approach, and the identification of the most appropriate number of source signals. A novel Bayesian approach of NMF tailored to facilitate the unsupervised multimodal analysis of MR data is planned to be developed, since Bayesian models deal with multimodal systems in a natural way, and the relationship between variables is explicit, as well as the handling of the prior knowledge. Data from pre-clinical models and hu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SiC composite claddings: LWR performance optimization for nominal and accident conditions' in the context of a Horizon Europe call.

assistant: **Objectives**

The Fukushima Daiichi event in 2011 demonstrated the need for enhanced nuclear energy safety, becoming a major driving force for global investments in accident-tolerant fuels (ATFs) over the past decade. Candidate ATF cladding material concepts that are being developed in replacement of the standard zirconium-based alloy (zircaloy) fuel cladding materials used in light water reactors (LWRs) must outperform commercial zircaloys under nominal operation, high-temperature transient (<1200°C) and accident (>1200°C) conditions. SiC/SiC composites are a rather revolutionary ATF cladding material concept exhibiting inherent refractoriness, pseudo-ductility, and a lack of accelerated oxidation during a loss-of-coolant scenario. Due to their unique potential in meeting the stringent property requirements of the ATF cladding application, SiC/SiC composites have already claimed large global investments. Despite these investments, all state-of-the-art variants of the SiC/SiC composite cladding material concept must still overcome inherent shortcomings prior to their perspective deployment. Two important weaknesses are their inadequate compatibility with the coolant (water and steam) and the early (<2 dpa) saturation of radiation-induced swelling during nominal operation. SCORPION strives for a radical improvement in the performance of SiC/SiC composite fuel claddings by highly innovative material tailoring on the nanoscale, so as to limit hydrothermal corrosion and radiation swelling, while also modifying the fibre/matrix interface for better stability under irradiation and in high-temperature oxidizing environments. SCORPION is an ATF application-driven international collaboration between Europe, the USA and Japan, which combines multidisciplinary scientific excellence, stakeholder
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'LARGE ROOF INTEGRATED PV ARRAY IN THE AACHEN COMBISOL PLANT'.

assistant: **Innovation**

- demonstration of an innovative photovoltaic generator, which is integrated harmonically into a biogas plant.- first application of a newly developed roof-integration system offering advantages with respect to costs, material use, cumulated energy consumption, and installation time. After detailed evaluation of the integration system (performance, reliability,etc. ), it will be commercialized on the open market; For subsequent projects, total costs well below 10 DM/Wp are expected.- exploitation of synergy of the newest photovoltaic system technology (string inverter technology, large area modules, plug systems, etc.) leading to improved plant monitoring, optimized energy yield, and reduced installation costs.- significant contribution from PV electricity to the energy supply of the bi-national industrial park Aachen/Heerlen. demonstration of the positive interaction between different RE sources (PV, WIND, Biogas).In the Combisol concept, it is a main idea to apply an integrated approach. In this approach, the specific requirements of the PV plant are taken into account at a very early stage in the planning phase of the building.For the Combisol plant, the preliminary building plans, which only considered the necessities of the biogas plant, were checked and modified. Optimization criteria were :optimal arrangement, ground plan, and south alignement of the buildings as well as type and slope of the roofs. Moreover, the total plant was changed to an aesthetic and attractive design. The intergated approach can lead to significant synergy effects. In the case of the Combisol plant, roof integration of the PV modules offers the opportunity to save the normal roof skin (trapezoid iron sheet) resulting in a credit of more than DM 120000.The combination of electricity product