RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Investigating the regulation of iron homeostasis by erythroferrone and therapeutic applications'.

assistant: **Concept**

The existence of an “erythron-related regulator” that intensifies iron absorption and its release from stores to meet the requirements for red blood cells synthesis was proposed in the 1950s. Delineating this mechanism is of high biomedical importance as the pathway could be targeted to develop novel treatments for iron-restricted anemias that are very frequent but for which current therapies are ineffective (e.g. infections, inflammatory bowel disease, cancer, or chronic kidney disease) and for iron-loading anemias (e.g. thalassemias). We have recently identified the hormone erythroferrone (ERFE) and showed that it could be the long-sought erythroid regulator of iron homeostasis. ERFE suppresses the synthesis of the iron-regulatory hormone hepcidin to facilitate the recovery from anemia but leads to secondary iron overload in β-thalassemia. The potential of ERFE in the treatment of iron disorders is tremendous but understanding its mechanism of action is a prerequisite to envision ERFE-based therapies. The identification of ERFE has opened new research areas and our project will be organized around four axes.1) Develop an assay to measure ERFE levels in human pathologies. Its contribution is not known and needs to be confirmed.2) Identify the receptor for ERFE, the signaling pathways triggered by ERFE, and molecules with agonist/antagonist effects, a prerequisite in the development of new therapies.3) Search for potential other erythroid regulators. We will take advantage of the Erfe-/- mice to determine whether hepcidin could be suppressed by an ERFE-independent mechanism.4) Study the potential of ERFE manipulation in therapy in the mouse. We will first establish a proof of principle in a mouse model of anemia (B. abortus). The benefits of ERFE antagonization will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Co-production CeLL performing Human-Robot Collaborative AssEmbly' (CoLLaboratE).

assistant: **Innovation**

Traditional manufacturing systems lack the necessary flexibility and reconfigurability that can allow short production cycles and fast deployment of the updated system. Although the use of automation technologies based on industrial robots can increase the adaptability of a production line, the desired flexibility cannot be achieved until abilities for genuine collaboration of the robots with the human workers are developed. CoLLaboratE will revolutionize the way industrial robots learn to cooperate with human workers for performing new manufacturing tasks, with a special focus on the challenging area of assembly operations. The envisioned system for collaborative assembly will be capable of allocating human and robotic resources for executing the production plan sharing the tasks according to the capabilities of the available actors. The CoLLaboratE project will build upon state-of-the-art methods for teaching the robot assembly tasks using human demonstration, extending them to facilitate genuine human-robot collaboration. To this end, a framework for equipping the robots and AGV mobile platforms with basic collaboration skills, such as load sharing, human touch recognition and human intention detection, will also be developed, coupled with deep reinforcement learning algorithms for increasing adaptability. Special attention will be paid to providing effective safety strategies allowing the use of a fenceless approach within the production cell. As a result, closer collaboration will be achievable and efficient production plans making optimal use of the available resources will be designed and executed. The proposed solution will be evaluated in four different pilot sites, which will be implemented as collaborative factory floors of the industrial partners in Italy, S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EULAC FOR ENERGY TRANSITION: RESEARCH INFRASTRUCTURES COOPERATION FOR ENERGY TRANSITION BETWEEN EUROPE AND LATINAMERICAN AND THE CARIBBEAN COUNTRIES' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

EULAC ENERGYTRAN intends to strengthen the cooperation between the European Union and Latin American and the Caribbean research infrastructures to tackle a common challenge: how to get a clean, sustainable and just energy transition. This project pursues its goal through the exchange, generation and transfer of knowledge among entities from a multidisciplinary approach (technological, environmental, social) and through the support to the development of public policies and regulatory frameworks towards climate neutrality.  This general goal will be achieved by four specific goals that respond the multidisciplinary approach, in tune with the complexity of the energy transition. Therefore, the project supports technological R&I to overcome the existing limitations of renewable energies but acknowledging these developments may have an environmental and social impact which must be addressed. This proposal wants to come up with ideas about how to achieve an energy transition compatible with environment protection and social justice. Energy transition is at the top of the political agendas of both regions, EU and LAC, so this project may contribute to consolidating it as a priority area of interregional scientific cooperation. This project will be carried out by a heterogenous and interdisciplinary consortium composed of eleven partners with wide presence in the EU and LAC. They include ERICS and an international organization, among other entities, from different areas of knowledge. This way the complexity of the energy transition is better tackled. Under this scheme, EULAC ENERGYTRAN will create a network of an interconnected and sustainable EU and LAC research infrastructures that contributes to energy transition by technological, social and sustainably strengthening the per
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards a transport infrastructure for large-scale CCS in Europe' (CO2EUROPIPE).

assistant: **Concept**

This project aims at paving the road towards large-scale, Europe-wide infrastructure for the transport and injection of CO2 from zero-emission plants. The project will prepare for the optimum transition from initial small-scale, local initiatives towards large-scale CO2 transport and storage that is to start around 2020, with key stakeholders in the field of carbon capture, transport and storage. This transition, as well as the development of CO2 infrastructure will be studied by developing the business case in a number of realistic scenarios. The project will result in a roadmap for CO2 transport infrastructure, with 2020 as the target year for start of large-scale CCS in Europe. The roadmap will be defined for all levels considered in the project, ranging from technical to organizational, financial and societal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a titanium composite brake part for weight reduction and hence lower fuel burn and emissions on a large, long haul aircraft' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project will develop the technical, business and market analysis required to develop, a viable performance and economic case for Airbus to invest in flight qualification of titanium metal matrix composite (TiMMC) drive bars for large civil airliners such as the Airbus A380. Lower aircraft weight results in reduced fuel consumption and CO2 emissions. These are commercial and regulatory drivers for airlines, hence an industry standard value of €700/kg saved is used as a premium to introduce new technologies.TISICS will demonstrate a novel fibre reinforced TiMMC technology to replace brake parts that are currently steel, due to the high operating temperature and loads. TiMMC matches steel but is 40% lighter equating to 110kg saving on an A380, lower mass savings are possible on other airliners however the annual build quantities are higher. For A380 the annual market is estimated at €3.5M to €4M per year. Airbus will be the primary customer with export sales outside the EU in the future. Introducing a new material technology to safety critical aerospace applications is challenging, especially for an SME, hence the need for an SME instrument programme. We must design, make and test proof of concept parts as well as travel to Airbus and its suppliers to obtain data and support for a phase two project.Phase 1 will engage Airbus to obtain design parameters. We must identify potential industrial processes and composite geometry for parts. TISICS will use the data to evaluate designs through FEA analysis and fabrication and basic test of parts made with different processes to assess manufacturing issues and costs.Phase 2 will develop processing and design to a high TRL to provide sufficient data that Airbus needs to justify investing in full qualification programmes. TISICS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'BIOSKOH’s Innovation Stepping Stones for a novel European Second Generation BioEconomy'.

assistant: **Innovation**

The BIOSKOH project will pave the way for a Second Generation European Circular Bioeconomy by showcasing how a number Innovation Stepping Stones can realise a breakthrough in techno-economic viability of lignocellulosic biorefineries. It will do so through a two stage investment process and development path to realise the largest (110 kton) second generation (2G) biorefinery in Europe. It starts from a brownfield industrial site in the eastern part of the Slovak Republic to realise the 1st stage Flagship plant to produce 55 kton of cellulosic ethanol per year for EU bio-fuel mandates. Partners include the full value chain starting from land owners and feedstock producers, supply chain experts and an agronomical research partner to set-up a new biomass value chain exploiting large amounts of currently unused crop residues (kton/year), and developing newly grown dedicated crops on marginal land (total circa 320 kton/year), as such revitalising the regional economy. Technology providers (Biochemtex, Novozymes and Lesaffre) developed, tested and demonstrated in the only available semi-industrial scale 2G biorefinery research plant, an innovative integrated pre-treatment, hydrolyses and fermentation package, with higher yield and lower CAPEX which will now be upscaled to the 1st of a kind commercial scale Flagship, to be built by Energochemica. Aim is to showcase techno-economic viability based on a sound business plan and 4 stepping stones (yield, biomass cost, brownfield and industrial symbiosis). Dedicated innovation actions by expert partners include assessing increased cascading potential through lignin valorisation and 2G bio-chemicals, LCA, Socio-economic impact analyses, business plan for a 2nd investment round, exploitation, dissemination and replication actions to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Self-organisation under confinement' (SOCON).

assistant: **Innovation**

Colloidal systems such as foams, emulsions and dispersions are widely used in industrial applications and everyday products, e.g. for household and personal care, pharmacy and food. However, the reason for their stability - or instability - is not yet unde rstood in sufficient detail. The reason is that we lack fundamental knowledge of the anisotropic environment which is induced by an interface and is then perturbed by the confinement between two neighbouring interfaces. These confinement-induced changes gi ve rise to interactions between the interfaces, which can be attractive or repulsive, and typically have a range of less than 100 nm. Most of these interactions are related to changes in the organisation within thin liquid films and interfacial (adsorption ) layers, but so far we do not know exactly how. SOCON aims to combine knowledge about the nanoscale organisation in bulk, at a single interface and between two interfaces in order to fully understand and predict the interaction forces between two interfac es across a confinement. SOCON will focus on the following complex issues of high industrial relevance: (1) Self-organisation of multicomponent systems at interfaces, (2) Trapped non-equilibrium states in polymer-surfactant systems, (3) The relations betwe en structure and surface forces, (4) The correlation between the properties of microscopic films and those of the corresponding colloidal systems, and (5) Incorporation of ecologically more friendly components in products (including the synthesis of novel composite polymers and surfactants from natural building blocks). The goal of SOCON is to gain a better understanding of the role interfacial layers and thin aqueous films have for the properties of colloidal systems. SOCON will counteract fragmentation by co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'EaRly Nutrition programming- long term Efficacy and Safety Trials and integrated epidemiological, genetic, animal, consumer and economic research. [EARNEST]'.

assistant: **Innovation**

What is known: post-natal nutritional programming of adult health is demonstrated by 1 Experi- mental animal studies 2 Historical; prospective human observational studies linking size at birth & infancy with adult disease 3 Experimental studies in selected groups of humans with limited follow-up. What is not known: The importance of early nutritional programming. to contemporary EU populations, precise nutritional exposures, timing; mechanisms, nor effectiveness of interven- tions to reverse adverse effects. EARNEST will establish: T9 a multi-disciplinary team of leading international scientists from major research centres across Europe working on critical aspects of nutritional programming, co-ordinated by professional management, with strong horizontal, verti- cal; sectoral integration T1 nutritional programming of adult disease risk by measuring adult disease markers in well-conducted randomised controlled trials of specific nutrition interventions in preg- nancy; infancy T2 quantitative importance of nut. prgr. in contemporary adult EU populations by examining later outcome in large well-characterised population-based prospective studies T3 mechanisms of nut. prgr. using functional genomics in animal, cellular and molecular studies T4 consumer attitudes to nutritional programming. T5 economic impact of nut. prgr. T6 demonstration projects to test new technologies with economic potential T7 professional approach to outreach; communication T8 multi-disciplinary training EARNEST outcomes: Best data from human trials; prospective studies, state of the art determination of mechanisms, critical time periods, key genes implicated in programming, evidence to guide improvements in infant formula; to formulate poli- cies on their composition; testing, interventions proven to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In Vivo Single-Cell Mechanomics of Bone Adaptation and Regeneration in the Aging Mouse' in the context of a Horizon 2020 call.

assistant: **Objectives**

Osteoporosis, one of the most prevalent degenerative diseases, is characterized by a reduction in bone mass and increased fracture risk and has been partly attributed to the decrease in mechanical usage of the skeleton. A detailed understanding of the molecular mechanisms governing load-regulated bone remodeling could therefore lead to the identification of molecular targets for the development of novel therapies. Bone remodeling is a multiscale process mediated through complex interactions between multiple cell types and their local 3D environments. However, the underlying mechanisms of how cells respond to mechanical signals are still unclear. By combining single-cell “omics” technologies with well-established tissue-scale models of bone mechanobiology, MechAGE proposes to develop the technology required to allow spatially resolved in vivo single-cell mechanomics of bone adaptation and regeneration. CRISPR/Cas technology will be exploited to generate fluorescent reporter mice to identify the different cell types involved in the bone remodeling process. By combining RNA-sequencing of single cells isolated by laser-capture microdissection with micro-finite element analysis and time-lapsed in vivo micro-CT, MechAGE will link the transcriptome of hundreds of single cells to their local mechanical in vivo environment (LivE). This will allow investigation of molecular responses of the cells to LivE changes with aging in established mouse models of bone adaptation and regeneration. In addition to in vivo mechanomics, MechAGE proposes to use cellular and multiscale computational modeling to run in silico simulations of real-world events for better understanding of diseases of aging in mice and to maximize the use of the high quality in vivo mechanomic data. Findings from Mech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Social protection, active citizenship and participatory democracy in western europe (SAPE)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Principal objective: clarify how ongoing changes in Western European welfare states affect the degree of active citizenship, labor market participation, user involvement and social mobilisation achieved on the part of people at the margins of these societies.Sub-goal 1: achieve in-depth, systematic and research based knowledge about current attempts to promote active citizenship in the UK, particularly more active participation from recipients of security benefits and compare this with experiences from the Nordic countries.Sub-goal 2: clarify how policy developments on a supra-national (e.g. EU) and nation state level in area are interrelated.Sub-goal 3: assess the consequences of various forms of active citizenship from the perspective of marginal people.Sub-goal 4: prepare comparisons with other Western European countries in this area. Organization of the visit: the visit will be organized around co-operation about writing drafts of chapters on active citizenship, and data collection about the British experience in the area. The project will be connected to already established collaboration about active citizenship and initiated in the COST A 13, WG 1 on unemployment headed by Professor Jochen Claesen at University. The project will also be connected to two internally related projects about active that already has been granted financial support. The Research Council of Norway will cover the to Dr. Halvorsen and some expenses related to data collection. The project is also connected to a Nordic comparative study that has recently been granted financial support from the Nordic Council Ministers for the period 2002-2004. A Marie Curie Fellowship would enhance increased mobility of younger researchers and contribute to a synergy effect between already existing projects. A