RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chip-Scale Optical Frequency Combs for Communications and Sensing: A Toolkit for System Integration' (CombTools).

assistant: **Concept**

Chip-scale Kerr comb generators have emerged as a novel class of light sources with disruptive potential for a variety of applications such as hyper-scale optical communications, LiDAR, high-resolution spectroscopy, or ultra-broadband signal processing. Still, Kerr combs have not yet found their way into commercially relevant applications. This is mainly caused by the fact that high-performance comb generators are currently not available as commercial products. Another obstacle is the lack of additional tools that are needed for comb-based signal processing.  CombTools aims at overcoming these obstacles by establishing a powerful technology base and a corresponding ecosystem for leveraging the full potential of Kerr combs in highly relevant application fields. On the technology level, we will develop copper-contamination-free silicon-nitride photonic integrated circuit with record-low propagation loss. Based on this, CombTools will offer low-barrier “democratized” access to comb generators with unprecedented performance, thereby preparing the ground for many follow-up innovations. We will further establish dedicated tools for comb-based signal processing, comprising comb-line processors, arrays of advanced electro-optic modulators, and control modules for comb synchronization. The performance of the developed technology will be shown in a series of ground-breaking demonstrations. CombTools brings together a carefully selected consortium that covers proven competences in technology, product engineering, and business development. The project can rely on a strong technology base developed by the group of Tobias Kippenberg at EPFL. This technology has been licensed to the high-tech start-up Deeplight, bringing Kerr-comb technology to the market through its German subsidiary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting macropinocytosis in glioblastoma to achieve precision medicine' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Tumors must survive microenvironmental stresses, such as nutriment deprivation, low levels of oxygen and anticancer treatments. To do so, tumor cells have developed numerous adaptation mechanisms, and we have recently shown that induction of macropinocytosis is associated with tumor cell survival. In our previous work, we determined that the Galectin-3 (Gal-3)/KRAS/alphavbeta3 integrin complex acts as a driver of macropinocytosis, an endocytic process by which tumor cells are able to engulf large amounts of nutrients from the local microenvironment. In glioblastoma (GBM) cells, which do not harbor mutations in KRAS, we interestingly uncovered the same phenomenon of macropinocytosis induction, which was associated with the mesenchymal subset of GBM. My recent work challenged this paradigm of oncogenes, such as oncogenic KRAS, essentiality for macropinocytosis activity in cancer cells. Although the mesenchymal subset is associated with variable expression of several genes, a molecular signature rather than a mutation in a single oncogene defines macropinocytosis. In this context, we also found Gal-3 to be involved in macropinocytosis induction in mesenchymal GBM cells, confirming the central role of Gal-3 in this process. Altogether, my results demonstrate that induction of macropinocytosis is not restricted to tumors bearing mutations in specific oncogenes but can potentially be a universal scavenger process used by tumor cells to survive environmental stress. In this context, the overarching goal of this proposal is to define the molecular mechanisms underlying cancer cell addiction to macropinocytosis, with the ultimate aim to identify targets for the therapeutic exploitation of this mechanism. To achieve this goal, we will combine various functional assays, metabolomi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Illuminating neutron stars with radiative plasma physics'.

assistant: **Objectives**

This research program will use first-principles radiative plasma simulations to understand how neutron stars radiate. Neutron stars are the culprits of the most infamous astrophysical emission enigmas: 1) pulsar radio emission, 2) multi-messenger signals of compact-object binary mergers, and 3) simultaneous generation of giant flares and fast radio bursts from magnetars. These emission mechanisms have remained elusive because we do not have a self-consistent theory that combines plasma physics (describing microscopic motions and energy dissipation of the magnetized gas) and radiative processes (describing the reprocessing of the energy into radiation).This project combines the forefront plasma physics theory with exascale high-performance computing technologies to achieve two breakthroughs: 1) generation of first-principles 3D models of the radiative plasmas around pulsars, mergers, and magnetars; and 2) development of a novel open-source simulation toolkit for self-consistent and high-fidelity modeling of astroplasmas. These enable a quantitative understanding of the unsolved emission mechanisms (including efficiency, variability, and output spectra) and direct comparison to observations.Analyzing astronomical observations with these superior physics-constrained models enable direct tests of their validity and a leap in improving the accuracy of the modern nuclear/particle physics theories of the still-unknown neutron star equation of state. The PI has a world-leading role in computational astroplasma physics, an established record of impactful and innovative research in the astrophysics of neutron stars, and 10 years of experience in state-of-the-art high-performance computing solutions.


**Keywords:** neutron stars, magnetars, pulsars, mergers, fast radio bursts,  r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modelling the inherent optical properties of highly turbid waters. development of new processing techniques for satellite and airborne sensors data.' (1998-2002).

assistant: **Innovation**

The research objective is a better understanding of the inherent optical properties (IOP) of highly turbid waters (i.e. rivers, estuaries and turbid plumes), where properties of suspended sediments are predominant. An IOP model will be developed, including notably the Mie theory to compute scattering optical properties of sediments as a function of sediment type (grain size distribution, refractive index). New techniques will be based on: video camera records to detennine in situ grain-size variations; improved measurements of optical properties in different highly turbid waters, using AC-9 and BB-4sensors, to quantify the absolution due to sediment and validate the IOP model. Numerous field reflectance measurements, taken in different geographical regions, will be integrated into a theoretical appropriate reflectance band ratios and suspended sediment concentration (SSC) will be established in each study area. Theoretical and empirical results will then be used m the development of improved algorithms for quantification of SSC from satellite (SPOT, Landsat, MERIS and CHRIS-PROBA)and airborne (CASI) remotely sensed data. The satellite and airborne imagery will be atmospherically corrected, using recently developed schemes, prior to the application of SSC algorithms.The selected study areas are the Gironde and Loire estuaries (in France) with the Humber and Tarnar estuaries (in UK), but the modelling results will be globally applicable. The training includes field campaigns in the different selected estuaries, to determine sediment types(grain-size distribution, mineral composition), measure water reflectance and lOPs. Recently developed sensors (video camera system, multi-band radiometers, AC-9 and BB-4) will be used, which will give me a great experience in collecting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Towards cost-effective dialysis therapy in Europe'.

assistant: **Concept**

Objectives:- To establish the most cost-effective mix of resources that would support dialysis therapy for End Stage Renal Disease in Europe, - To develop protocols for improving the quality of such dialysis services throughout Europe.European member states spend different proportions of their Gross Domestic Product on health and different amounts of resource on specific services. There is an urgent need to measure the quality and cost of health care interventions in different European countries particularly in resource intensive areas. Dialysis is one of the most expensive treatments in medical practice and without it or a kidney transplant, patients with end stage renal disease (ESRD) will die. Dialysis technology is now advanced and safe and older patients with comorbid illnesses can be successfully treated. The number treated is rising rapidly (threefold since 1980) as the population ages in most European countries and demand grows in eastern Europe. We have found that survival in patients with ESRD was significantly influenced by comorbid illness and showed, for the first time in Europe, that even after adjusting for comorbidity and age there remained significant differences in patient survival among centres. Despite such evidence it is unclear how resources for dialysis can be deployed most cost-effectively to achieve optimal outcomes at least cost. The aim of this reinforced concerted action is to establish the most cost-effective mix of resources that would support dialysis therapy in Europe. As a result we shall develop protocols for improving the quality of dialysis services throughout Europe.The following objectives will allow us to achieve this aim:1. To compare the nature, volume and costs of the resources devoted to the provision of chronic dialysis treatm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'TM Academy - intelligent transport control and monitoring system' (2014-2020).

assistant: **Innovation**

It is already for 8 years that UAB Medium Group has been successful in the field of design and development transport control and monitoring systems. The needs newly arising on the European transport market prompted it to invest in new product-the intelligent TM Academy software designed for the analysis of a driver’s performance and automated transmission of necessary information concerning different areas (working time and rest period; safe and economical driving; road traffic accidents; regulations on carriage of goods; TIR and CMR Conventions; customs procedures; prevention of carriage of illegal goods, etc.), also subsequent evaluation of the driver for the purpose of achieving better performance. The database of the application will consist of the requirements of the legislation relevant to the this sector. The system will have direct interfaces with vehicle systems and the CAN bus, so it will receive necessary information about the performance of a driver and, in this regard, will automatically select details required for its improvement. It will educate employees and will contribute not only to the better performance and operating results of a given employee and the company as a whole, but also to the handling of global issues, such as reduction of pollution, enhancing effectiveness of the transport system, decreasing the number of road traffic accidents, etc., as a result, benefiting drivers, transport and recruitment companies and country concerned. This software has no parallel in Europe or other countries, since similar products excludes any automated operation involving a driver and intended to improve his performance.Outcomes of the feasibility study: identification of the scope of the database and required integrations with vehicle systems; prepared projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fabricating vegan and circular leather alternatives from bio-tech derived cellulose' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Fabulose project seeks to transform the production of animal-free leather alternatives by developing sustainable, circular materials derived from biotech processes. Our goal is to create high-performance, fully biodegradable leather substitutes from bacterial cellulose (BC) and cyanophycin, replicating the properties of traditional leather while reducing environmental impact. By employing advanced fermentation techniques and AI-driven optimizations, we will scale the production of these bio-based materials to meet the demands of industries such as automotive, footwear, and upholstery.To ensure these materials are sustainable throughout their lifecycle, digital tools such as the Digital Twin (DT) and Digital Product Passport (DPP) will monitor, optimize, and track production processes and material performance. This will also support transparency and enable efficient recycling management, aligning the project with circular economy principles.Fabulose will significantly contribute to the European Green Deal by offering alternatives that are not only animal-free but also minimize resource consumption and environmental harm. By focusing on innovation, we aim to enhance Europe's competitive position in sustainable materials, delivering eco-friendly products that meet stringent technical and regulatory standards. The project outcomes will help replace fossil-fuel-based materials with a scalable, environmentally responsible solution, promoting healthier ecosystems and sustainable consumption.


**Keywords:** biobased animal-free leather alternative, circular economy, bacterial cellulose, cyanophycin, demonstration plant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Natural products and their cellular targets: A multidisciplinary strategy for antibacterial drug discovery' (ANTIBACTERIALS) under Seventh Framework.

assistant: **Objectives**

After decades of successful treatment of bacterial infections with antibiotics, formerly treatable bacteria have developed drug resistance and consequently pose a major threat to public health. To address the urgent need for effective antibacterial drugs we will develop a streamlined chemical-biology platform that facilitates the consolidated identification and structural elucidation of natural products together with their dedicated cellular targets. This innovative concept overcomes several limitations of classical drug discovery processes by a chemical strategy that focuses on a directed isolation, enrichment and identification procedure for certain privileged natural product subclasses. This proposal consists of four specific aims: 1) synthesizing enzyme active site mimetics that capture protein reactive natural products out of complex natural sources, 2) designing natural product based probes to identify their cellular targets by a method called  activity based protein profiling , 3) developing a traceless photocrosslinking strategy for the target identification of selected non-reactive natural products, and 4) application of all probes to identify novel enzyme activities linked to viability, resistance and pathogenesis. Moreover, the compounds will be used to monitor the infection process during invasion into eukaryotic cells and will reveal host specific targets that promote and support bacterial pathogenesis. Inhibition of these targets is a novel and so far neglected approach in the treatment of infectious diseases. We anticipate that these studies will provide a powerful pharmacological platform for the development of potent natural product derived antibacterial agents directed toward novel therapeutic targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Gender and qualification. transcending gendered features of key qualifications for improving options for career choice and enhancing human resource potential' (GENDERQUAL).

assistant: **Concept**

The project will investigate the impact of gender segregation of European labour markets on vocational education and training, with special regard to key qualifications. Gender barriers prove to be inadequate for a modernisation of work processes and lose validity because of impeding both career options of women and men and human resource development. VET systems should aim at competences corresponding to these challenges and at equal opportunities for both sexes. It will be investigated to which extent women and men tend to develop gender specific key qualifications or dispose of them differently. VET and CVT strategies of qualification will be specified allowing to overcome gender segregation in the labour market / to improve employability of both sexes / to prepare for occupational changes. Corresponding recommendation for policy makers and practitioners will be designed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European paediatric orthopedic society - training course' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

European Paediatric Orthopaedics Society (EPOS) proposes four events as an educational programme for young physicians who are keen to specialize in paediatric orthopaedics and trauma. Each event comprises of five-day courses to be held over a period of approximately two years in internationally highly respected paediatric orthopaedics centres. The events are designed to fill the need for a standardized, high-quality European training and scientific research in paediatric orthopaedics, and aim to enhance the exchange of knowledge and experience and to deepen the cooperation between European orthopaedic surgeons for the benefit of disabled children, increasing as well the participation of women and of researchers from less-favoured regions of the EC and Associated Countries.The courses will be hosted by three EC member states and one associated state: Austria (Orthopaedic Hospital Vienna - Speising), Finland (ORTON Orthopaedic Hospital - Helsinki), France (Hopital de la Timone Enfants - Marseille) and Israel (Tel Aviv University, Dana Children's Hospital - Tel Aviv). The participants form a geographic trapezium that unites four parts of Europe, respectively: North, South-East, South-West and East / Middle East. The EPOS Training Courses will take part in Vienna in January 2008, in Helsinki in July 2008, in Tel Aviv in January 2009 and in Marseille in July 2009. The courses form a comprehensive coverage of the field of paediatric orthopaedics and trauma, such as upper/lower limbs deficiencies, spine deformities, cerebral palsy, tumours, and bone dysplasias.Through frontal lectures, group discussions, and live demonstrations of state-of-the-art treatment of musculoskeletal problems, workshops and hands-on sessions, the courses will achieve the transfer of knowledge from wor