RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Role of Physiology in the Causes and Consequences of Fisheries-Induced Evolution'.

assistant: **Innovation**

There is increasing evidence that intense commercial fishing pressure is not only depleting fishstocks but also causing evolutionary changes to fish populations with serious consequences for the viabilityof marine fish communities. Although current research on fisheries-induced evolution (FIE) has focusedalmost exclusively on the effects of size-selective harvest on reproductive potential of wild populations, thereare a range of traits besides body size which could also affect the selectivity of fishing gears but which havenot been investigated. For example, overlooked within the context of FIE is the likelihood that, within agiven species, variation in physiological traits among individuals – and especially those related to energybalance (e.g. metabolic rate) and swimming performance (e.g. aerobic scope) – could make some fish morecatchable or more likely to suffer mortality after discard. Selection on these traits could produce major shiftsin the fundamental structure and function of fish in response to fishing pressure that are yet to be consideredbut which could directly determine population resource requirements, resiliency, geographic distributions,and responses to environmental change. This pioneering project will combine innovative approaches in thelaboratory with cutting-edge acoustic tracking technology in the field to address this gap in knowledge withthree main goals: (1) to examine whether physiological traits make some individuals more catchable bycommercial fishing gears, and whether the environment modulates such effects; (2) to investigate the extentto which physiological traits influence recovery and survival after escape from fishing gear or discard; and(3) to determine whether selection on catchability generates changes in physiological traits that r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Laser Aided Investigations in Cardiology' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objectives are to develop techniques for optical identification of diseased cardiovascular tissue to a technological level, where their potential usefulness in cardiology can be evaluated. Several different laser spectroscopy techniques and potential candidates for transluminal diseased tissue identification will be examined. The spectroscopic techniques to be evaluated are laser-induced fluorescence, diffused reflection, Raman and infrared spectroscopy. In vitro tissue studies will be performed for several types of cardiovascular tissue abnormalities of interest for transluminal identification: vessel stenosis, RF-ablation-related tissue lesions, tissue characteristic of arrhythmia foci" and early tissue changes indicating a rejection of a transplanted heart. Clinically adapted instruments based on the two best performing techniques will constructed, and compared in clinical studies.The development of laser assisted diagnostic techniques is now a rapidly growing field in biology and medicine, as it has been demonstrated to provide unique information making it possible to identify diseased tissue. In cardiology there exists a need to nonintrusively identify several types of lesions in real time. Such lesions include atherosclerotic plaques occluding blood vessels, characteristic of myocardial tissue acting as foci for arrhythmia and tissue changes in connection with transcatheter ablation or immune rejecting responses following a heart transplantation. The possibilities to develop minimally invasive diagnostic and therapeutic techniques are key issues in the present programme concerning laser-based minimally-invasive diagnostic techniques. The development of reliable techniques that could identify diseased tissue with a transluminal examination, without the need for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Structural studies of HK97 bacteriophage assembly and maturation'.

assistant: **Objectives**

Virus maturation is virtually universal and allows the transition from an initially assembled non-infectious and fragile particle to a robust infectious virion. Siphophage HK97 is an accessible model system, to study assembly and maturation, for which intermediates can be isolated and myriad structural, biophysical and biochemical data are available. The capsid protein fold similarity between HK97, all other dsDNA bacteriophages and some animal viruses suggests that they share common maturation principles. The proposed project seeks to unravel the mechano-chemical reorganization program underlying the structural transitions observed during HK97 procapsid maturation using hybrid methods. It relies on a multi-disciplinary approach involving X-ray crystallography, electron microscopy and tomography to obtain multi-scale data ranging from atom to whole-cell. We aim to obtain structures of three different HK97 procapsid maturation intermediates to shed light on mechanisms involved in initial assembly of an energy-loaded particle as well as on forces driving forward maturation. We will also use electron tomography to study in vivo aspects of HK97 assembly and maturation in Escherichia coli infected cells. The outcome will allow apprehending mechanisms, dynamics and energetics of viral maturation as well as provide a basis for the use of HK97 as a delivery system for nano-medical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A novel integrative strategy to prevent colorectal cancer within the diet-host-microbiota triangle: from organoids to human in vivo reality'.

assistant: **Objectives**

Colorectal cancer (CRC) is the second cause of death in the EU, and so far, diet has been accounted for up to 80% of the cases. In this context, dietary phytochemicals have received increasing interest due to their suspected role in the prevention of cancer. Numerous studies report the chemopreventive effects of polyphenols. However, health benefits assigned to dietary constituents are still under controversy as can be deduced from the large number of applications rejected by the EFSA (health claims). Despite the crucial role of polyphenols in many biological cases, adequate tools to decipher the relationship between diet-microbiome-host are not yet available. To unveil the mysteries in the emerging field of personalized nutrition, this proposal aims to develop a new in vitro model for the study of phytochemicals in CRC prevention.The most common approach to study the anti-proliferative activity of polyphenols against CRC involves the use of 2D cell lines. Although multiple hints on the possible anticancer effects of these compounds have been already published, these results cannot be extrapolated to human. Firstly, immortalized 2D cell lines differ metabolically from in vivo cells. Secondly, these compounds were not artificially digested and fermented. Therefore, a novel integrative strategy to deepen understanding of CRC is vital. To accomplish this, a real-life scenario is needed. In this context, colon organoids/tumoroids will be established. Afterwards, an apple will be digested/fermented in vitro using a batch culture colonic model inoculated with feces from lean/obese healthy donors. In the end, such polyphenol metabolites will be tested in colon organoids/tumoroids and the mechanisms of action will be revealed by metabolomics and organoids assays. The outcome of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Methane monitoring in the european region' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This proposal is to create a European Monitoring Network to measure Atmospheric Methane. The network will unify the present disparate national efforts, to create a valid European contribution to match the present efforts by other nations. The network will provide data for regional modelling of methane in the atmosphere, over Europe and over the major gas field and wetland source areas of Siberia. The work will be closely linked to work of Europe-Europe another projects. Sensitivity studies with regional models will help design accost effective sampling network, that will enable regional quantification of emissions. The work proposed will provide a basis for methane study under the 6th Environmental Action Plan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Theoretical developments for precision spectroscopy of polyatomic and polyelectronic molecules' (POLYQUANT) under Horizon 2020.

assistant: **Objectives**

I propose research for an increasingly accurate quantum mechanical computation of small molecular systems including non-adiabatic, relativistic, and radiative effects. The computed rovibronic energy intervals will be directly comparable with high-resolution and precision spectroscopy measurements. The accuracy goal for theory (and experiment) is more than six-orders of magnitude tighter than the usual chemical accuracy defined to be on the order of 1 kcal/mol. The rovibronic eigenstates obtained from effective non-adiabatic, relativistic-radiative Hamiltonians to be developed will provide the most fundamental and most detailed quantum dynamical fingerprint of the molecular system, and as a complete database they are necessary for the simulation of a variety of molecular phenomena including ultrafast laser-molecule interactions.


**Keywords:** theoretical molecular quantum dynamics of small, gas-phase molecules,  , non-adiabatic, relativistic and radiative effects in the molecular spectrum,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Teachers in the postdigital era: Tracing Teacher Postdigital Professional Identities (TePPI) across educational ecosystems and career stages'.

assistant: **Objectives**

At a time when education systems worldwide face a teaching vocational crisis and urgThis project investigates teacher postdigital professional identity (TePPI): an innovative framework for understanding how teachers’ professional roles, agency, and values emerge and evolve in deeply digitally entangled education ecosystems.  Using a longitudinal, mixed-methods design that integrates Epistemic Frame Theory (conceptual foundation), Quantitative Ethnography (research approach), and Epistemic Network Analysis (analytical method), the study will trace TePPI markers (pedagogical values, roles, agency, reasoning) in both traditional and postdigital education contexts across initial teacher education and early career stages. The unprecedented TePPI model will be shaped through the unique research environment of Monash’s Virtual School, while its robustness and generative potential will be leveraged at the University of Padova to drive curriculum reform within a rapidly transforming teacher education system. Ultimate outputs will be validated research instruments, evidence-based models of TePPI trajectories, and TePPI-informed teacher education modules co-designed with stakeholders. Beyond academia, outputs such as toolkits, guidelines, and policy briefs will benefit teacher educators, mentors, and policymakers, strengthening teacher preparation and retention. The project combines advanced methodological research training at Monash University with real-world curriculum reform at the University of Padova. Outcomes will contribute to European and international educational priorities (see the Digital Education Action Plan 2021–2027 and SDG4), by fostering competent, resilient and adaptable teachers for postdigital education ecosystems. By integrating interdisciplinary insights and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Autonomous manufacture of large steel fabrications' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

European, structural steel fabrication companies have difficulty in responding to the increasingly turbulent, competitive markets into which they sell and to customers who are ever more demanding about the cost, quality and performance of the products that they buy. They are also subject to legislative and employee pressure requiring improved and safer working conditions. Much of their difficulty is associated with the constraints imposed by the inflexible, dedicated equipment and production processes that they currently use. This project is aimed at the development and integration of technologies allowing replacement of the assembly line based approach to welded fabrication with automated, constraints free manufacturing in which the welding process is brought to the part to be fabricated. The proposed system will enable the production of high quality, customised products and will utilise autonomous, mobile robots in place of humans in hazardous areas of the fabrication environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Designer Cellulosomes by Single Molecule Cut & Paste' in the context of a Seventh Framework call.

assistant: **Objectives**

Biofuel from wood and waste will be a substantial share of our future energy mix. The conversion of lignocellulose to fermentable polysaccharides is the current bottleneck. We propose to use single molecule cut and paste technology to assemble designer cellulosoms and combine enzymes from different species with nanocatalysts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Materials recycling centre of excellence'.

assistant: **Innovation**

Principal objective is creation of the Materials Recycling Centre, which will be a leading centre in Central Europe, devoted to recycling a different kind of materials. Its mission is dissemination of knowledge on recycling of various products (waste packaging, end-of-life vehicles, electronics, buildings) and integration with the European Research Area through networking, exchange and twinning. MRC aim is implementation of sustainable development rules into practice. The project has been addressed to different groups of society:administration,business,consumers andyouth.A scope is Europe-wide, including 8 EC states, 6 NAB states, Israel, Turkey, Croatia, Ukraine and Russia. Majority of activities have been located in Poland, but also the Czech Republic, Hungary, Ukraine and Russia will host activities of the Materials Recycling Centre.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Speech Driven Multi-modal Automatic Directory Assistance', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

SMADA addresses all technology aspects (Automatic Speech Recognition (ASR), dialogue design and Human Factors (HF) issues) needed to automate large proportions of the Directory Assistance requests handled by Network Operators. SMADA intends to improve the robustness and accuracy of very large vocabulary ASR by developing confidence measures for isolated words and multi-words expressions, progressive search, and unsupervised learning techniques to update acoustic and language models on the basis of recordings in operational services. Access from the fixed and cellular networks is investigated, both for uni-modal voice and multi-modal Web versions of the service. SMADA will investigate Distributed Speech recognition, especially for this type of service. Realistic field tests will be performed with uni- and multi-modal demonstrators to guarantee the right directions of HF and ASR research. Objectives:SMADA aims at improving all aspects of the technology needed to automate a large part of the calls to the Directory Assistance service without compromising customer satisfaction. SMADA aims at a breakthrough in the robustness and accuracy of ASR technology by developing confidence measures, noise robust decoding, progressive search and techniques for unsupervised learning from the speech recorded during operation of the service. SMADA will build demonstrators for mono- and multi-modal access to DA, which are used for realistic field trials. Human Factors research addresses issues related to caller-system, and in the case of partial automation, operator-system interaction. Attention will be paid to calls from the fixed and cellular networks. SMADA addresses both mono-modal voice access and multi-modal access to Web-based DA services. Protocols supporting distributed speech reco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unravelling the mechanism for development of WASP-associated primary immunodeficiency' (WASPSTINGS) under Seventh Framework.

assistant: **Objectives**

Two severe primary immunodeficiencies; Wiskott-Aldrich syndrome (WAS) and X-linked neutropenia (XLN), are caused by mutations in the same gene encoding the WAS protein (WASP). WASP is a hematopoietic cell-specific cytoskeletal regulator that coordinates receptor signalling to changes in the actin cytokeleton, thereby altering migratory, adhesive, phagocytic, and signalling responses. WAS is caused by loss-of-function mutations in WASP. WAS patients and WASP-deficient mice are immuno-compromised, fail to respond to foreign pathogens, and are prone to develop eczema and autoimmune disease. In contrast, XLN is caused by gain-of-function mutations that lead to a constitutively-active WASP. XLN patients suffer from severe congenital neutropenia. It remains unknown how different mutations in WASP can induce vastly diverse clinical phenotypes. I hypothesize that similar to WASP deficiency, XLN-WASP mutations may affect hematopoietic cells broadly. Moreover, I hypothesize that altered tolerance to self leads to induction of eczema and autoimmunity in WAS patients and WASP-deficient mice. I propose; AIM 1: To reveal the underlying cause for development of XLN by usage of a novel mouse model that I generated during my postdoctoral work. We will determine how XLN-WASP influences the immune response, induces neutropenia, and tumour transformation. AIM 2: To investigate how WAS patients and WASP-deficient mice that fail to respond to foreign pathogens still react vigorously to self and develop eczema and autoimmunity. This project is carried out as a multidisciplinary and translational collaboration together with my postdoctoral mentors in the USA, and researchers in Italy, England, and Sweden. The long-term goal with the project is to increase the mobility of European researchers a