RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Risk assessment of antimicrobial agent use in aquaculture' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The aim of this work is to investigate the degree of variation in the tetracycline resistance encoding plasmid population in strains isolated in the aquatic environment and those isolated in the human compartment. From this data a one or two compartment model will be constructed which best describes the distribution of tetR genes and movement of R+plasmids between compartments of the total environment. This model will then be used to provide an estimate of the possible extent to which the use of anti-microbial agents in aquaculture will have an impact on the use of these agents in human medicine. The choice of tetracycline resistance for construction of this model is based on two considerations:- the agent is used in both human and veterinary medicine- the mechanisms of resistance and the genetic determinants of resistance towards this agent have been well characterisedModel construction will be based on analysis of a master strain set of mesophilic Aeromonas and general heterotrophic bacteria. The choice of two separate bacterial groups to include in the master strain set will provide two levels of analysis- data from the general heterotrophs will provide information of the general plasmid population structure of each environmental compartment- data from the mesophilic Aeromonads will allow comparison of specific plasmid population structures in related bacterial present in both compartmentsIn the first year validation was carried out on a limited strain panel of general heterotrophic organismsand mesophilic Aeromonads from both environments. This decision was informed by the desire to maximise resources while producing protocols of relevance to the programme. The validity of the project is totally dependent on the application of identical methods by each of the three
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies' in the context of a Horizon 2020 call.

assistant: **Objectives**

The MSC OUTstandINg project will use bioorthogonal click chemistry as tool to covalently attach magnetic nanoparticles (MNPs) to living cell surfaces with the aim to address two fundamental questions in the field of magnetic hyperthermia therapy using MNPs: 1) how the subcellular localization (on the plasma membrane or inside the cells) of MNPs affects their heating behaviour when compared to MNPs in solution 2) how MNPs immobilization and sub-lethal magnetic hyperthermia impact different subcellular signalling pathways and the biophysics of cell membranes. OUTstandINg is a multidisciplinary two-years research project built upon the expertise of the Fellow (Dr. Raluca M. Fratila) in bioorganic chemistry (including click chemistry, bioconjugates and functionalization of surfaces and (nano)materials) and the experience of the supervisor (Dr. Jesús Martínez de la Fuente) and of the host group (GN2 - Nanotherapy and Nanobiosensors, University of Zaragoza, Spain) in nanotechnology and nanomedicine. This MSC action will offer the Fellow the possibility to work in one of the top European institutions in nanoscience, where she will further develop her skills and will acquire new skills and knowledge necessary for the progress of her scientific career towards an independent position. The secondment period at University College London Institute for Biomedical Engineering (supervisor Prof. Quentin Pankhurst) will reinforce and complete the multidisciplinary training-through-research. The project will generate important knowledge and collaborations in the European Research Area (ERA) and will contribute to enhance the excellence of ERA through cutting-edge research at the frontier of chemistry, physics, materials science, cell biology and nanotechnology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Measuring the value of the Key Performance Indicators (KPI) of the 2Zero Partnership' under Horizon Europe.

assistant: **Concept**

The 2ZERO Partnership KPIs are multiple and various, relating to the three-layer approach for the Objectives of 2ZERO, as expressed in its SRIA. This proposed CSA will determine a common framework for monitoring these multiple and various KPIs (including their sources, methods and reporting formats). It will generate values for the KPIs and their expected variation for the coming decade, based upon the results of the projects being conducted within the partnership and the assessment of the impact of these projects' results. The proposed CSA will support the identification and quantification of all interactions, impacts and effectiveness of the partnership within the road transport challenge. Furthermore, the proposed CSA will provide recommendations for development and analysis of the means of measurement and evaluation of the partnership within the road transport challenge. Finally, the CSA will disseminate and communicate its results to a wide range of stakeholders, throughout the road transport sector, but also across Member States and to the public in general, via a range of media and events. The consortium undertaking the proposed CSA represents many sectors of the road transport community from multiple European countries: it will be guided by a strong Advisory Board representing a broad range of vehicle manufactures, suppliers, RTOs, operators and infrastructure providers, as well as technology partnerships, joint undertakings and other representative organisations within Europe.


**Keywords:** Road transport,  towards zero emissions,  partnership key performance indicators,  evaluation methods and measurements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design of embedded mixed-criticality CONTRol systems under consideration of EXtra-functional properties' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Up to now mission & safety critical services of SoS (Systems of Systems) have been running on dedicated and often custom designed HW/SW platforms. In the near future such systems will be accessible, connected with or executed on devices comprising off-the-shelf HW/SW components. Significant improvements have been achieved supporting the design of mixed-critical systems by developing predictable computing platforms and mechanisms for segregation between applications of different criticalities sharing computing resources. Such platforms enable techniques for the compositional certification of applications' correctness, run-time properties and reliability.CONTREX will complement these important activities with an analysis and segregation along the extra-functional properties real-time, power, temperature and reliability. These properties will be a major cost roadblocks when 1) scaling up the number of applications per platform and the number of cores per chip, 2) in battery powered devices or 3) switching to smaller technology nodes. CONTREX will enable energy efficient and cost aware design through analysis and optimisation of real-time, power, temperature and reliability with regard to application demands at different criticality levels. To reinforce European leadership and industrial competiveness the CONTREX approach will be integrated into existing model-based design methods that can be customized for different application domains and target platforms.CONTREX will focus on the requirements derived from the automotive, aeronautics and telecommunications domain and evaluate its effectiveness and drive integration into existing standards for the design and certification based on three industrial demonstrators. Valuable feed-back to the industrial design practice, standar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Project Fortitude: Improving children's legal capability' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The aim of this project is to improve the legal capability of children. This focus on children breaks new ground because other research into legal capability focuses on adults. On paper, children are both empowered and protected by numerous laws and international rights instruments. In practice, however, we know that millions of children live at risk of violence, abuse and neglect in the UK alone. The proposed research seeks to create a range of resources that will empower and enable children who are at risk to enforce their legal rights independently; so increasing the likelihood of them accessing support and securing protection from harm. As well as targeting children at risk, this project seeks to strengthen all children’s capability to deal effectively with the many law-related issues that they encounter in their day to day lives. This is based on the view that children are competent social actors, whose views should be taken seriously. The project aim will be achieved through three work packages: 1. We will draw on the experiences of children to co-create a child-centred framework of attributes of legal capability.2. We will co-create a range of game-based interventions that will both measure and improve these attributes, drawing on theories of play. 3. We will optimise the effectiveness of these interventions by determining what works best, in what circumstances, for improving attributes of legal capability among children.  We will also develop a specification of the process by which such interventions can be created and optimised.  The project will provide a range of game-based resources that will improve the lives of children by providing them with opportunities to improve their legal capabilities, as well as providing a framework for the development of these re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Environmental Nanoplastics Liver Impact and Variability in Endogenous Networks', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

ENLIVEN is a research-through-training project designed to equip researcher with key expertise to tackle challenges in nanotoxicology. Plastic pollution has rapidly surpassed unprecedented in less than a century, with microplastics (MPs) found across various environments, ecosystems, and within the human body. MPs are present in the food we eat, the air we breathe, and the water we drink. While current analytical techniques limit the detection of nanoplastics (NPs <100 nm), plastic degradation continues beyond the microscale, leading to nanoscale interactions with potentially unknown consequences. NPs pose significant environmental and public health risks, particularly due to chronic exposure to harmful chemicals. Environmental nanoplastics (eNPs) are of particular concern due to their ability to penetrate cells and vital organs, increasing their retention in organisms. However, most research focuses on the environmental impact of MPs and NPs, leaving critical gaps in understanding their long-term effects on public health and biology. ENLIVEN aims to address this by uncovering the biological mechanisms of eNPs, examining their degradation, liver resilience, and long-term health impacts. Using human liver organoids and zebrafish embryos, ENLIVEN will study genes related to tolerance, sensitivity, and heritability, alongside liver resilience. The project proposes an innovative, integrative approach in predictive toxicology, combining bottom-up and top-down methodologies. It will link Adverse Outcome Pathways (AOP) through single-cell combinatorial RNA-seq and explore phenotypic variability via Drug-Induced Liver Injury studies in human liver organoids. This research will advance comparative human toxicology by revealing the biological mechanisms that respond to eNPs throu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards Low Impact and Innovative New Concrete Structures: Exploitation of FRP Fabric Reinforcement' (TLIINCSEFFR), addressing dissemination and exploitation.

assistant: **Impact**

Building industry is eagerly looking for solutions to save embodied energy and to facilitate the EU’s goal of reducing 80-95% carbon emissions by 2050. However, traditional construction techniques and reinforcement materials limit the geometry and concrete-reinforcement configuration of concrete structures, resulting in almost invariable consumptions of embodied energy produced by concrete elements with a given design capacity. This generates the need for innovative concrete elements with a great potential to save embodied energy.This study proposes 3D GFRP fabric reinforcements capable of being both formworks and reinforcements to construct concrete elements with optimized geometries and concrete-reinforcement configurations, consuming less embodied energy, but having higher material efficiency and lower impact construction. First, experimental tests and numerical analysis will be conducted to achieve desired bond, anchorage and fibre layout properties for fabricating the GFRP reinforcements. Finite element models with the inputs of those properties will be built to predict the stress distribution across non-planer cross section produced by fabric formworks for developing design criteria. Based on the criteria, a numerical code will be developed to achieve the optimal design iteratively. Then, the optimal design will be evaluated with experiments and simulations. Based on experimental and numerical findings, a design criterion will be proposed for 3D GFRP reinforced concrete elements with potentials to reduce material demands and embodied energy up to 40%.  The Researcher will bring in the latest updates on adhesive bonds and anchorages as well as Prof. Jirsa’s (ACI President 2000) advice to improve the 3D FRP fabrics proposed by the Supervisor. The fellowship is expec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced Molecular ENantiodiscrimination' (AMEN), addressing dissemination and exploitation.

assistant: **Impact**

Enantiodiscrimination is one of the major challenges in contemporary chemistry. Chiral molecules exist in two non-superimposable mirror image forms, which induce different effects in biological systems. Thus, they need to be produced in a stereoselective way, especially for pharmaceutical use. The motivation and societal relevance of this project is based on the fact that if the wrong enantiomers are present in pharmaceuticals, their effects can be toxic or even lethal, as has been exemplified by the scandal around the use of racemic mixtures of thalidomide in the 1960ies. Subsequently, it became obvious, and strongly recommended by the FDA and European legislation, that medication should contain pure enantiomers. Therefore, there is a strong and constantly increasing need to develop advanced technologies that allow a selective production of enantiomers by new synthesis strategies. This challenge is at the heart of the AMEN project.  We plan to follow an unconventional concept, developed during the ERC Advanced grant ELECTRA, in order to obtain single enantiomers instead of racemic mixtures. This is achieved by directing the transformation of molecules towards one of the two possible enantiomers with the help of autonomously moving chiral microreactors.The fundamental strategy has been already validated with proof-of-principle experiments during the ERC Advanced project and showed extremely high selectivity, efficiency, and controllability, however only at the laboratory scale. Therefore, we plan as a next logic step with technology transfer character, to investigate in detail the possibility of scaling up this process and to evaluate its commercial viability and competitivity.


**Keywords:** Enantioselective synthesis,  Chirality,  Microswimmers,  Microreactors,  Self
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Inducible Human Photoreceptors for Research, Development and Therapy to Prevent Blindness' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

One of the major causes of adult visual impairment and blindness in industrialized countries is the progressive dysfunction and death of photoreceptor cells (PR) as a result of retinal degenerative diseases. Current treatment options are still insufficient to counteract these forms of blindness. The development of many drugs and therapies fail in preclinical stages because the used animal models are suboptimal for translating results from the bench to the bedside. Especially, for testing the transplantation of human PRs, which is currently extensively explored as a treatment option for late stages of retinal degeneration, the biggest bottleneck is the lack of PR material in sufficient quantity and quality. Within the ERC Starting Grant ProNeurons, my team and I have developed a disruptive technology to differentiate human induced pluripotent stem cells (hiPSCs) to PR precursor cells by overexpressing three transcription factors yielding in up to 60% in only 10 days. Our technology allows fast, efficient and unlimited production of PRs essential as testbeds for drug screenings, for further disease research and for photoreceptor replacement therapies. Within the PoC actions, we strive for bringing the induced PRs closer to the market. We will finalize the last product development steps and FTO reviews to define the final products such as PR differentiation kits and/or cryopreserved PRs for research, development and therapy. We will identify and approach industrial exploitation partners for out-licensing or further funding. The final goal of commercializing the induced PRs is to aid the development of new drugs to treat retinal degenerative diseases.


**Keywords:** retinal degenerative disease, hiPSC technology, human photoreceptors, drug screening, cell therapy, research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multimodal Extreme Scale Data Analytics for Smart Cities Environments' (MARVEL) targeting Horizon 2020.

assistant: **Abstract**

The “Smart City” paradigm aims to support new forms of monitoring and managing of resources as well as to provide situational awareness in decision-making fulfilling the objective of servicing the citizen, while ensuring that it meets the needs of present and future generations with respect to economic, social and environmental aspects. Considering the city as a complex and dynamic system involving different interconnected spatial, social, economic, and physical processes subject to temporal changes and continually modified by human actions. Big Data, fog, and edge computing technologies have significant potential in various scenarios considering each city individual tactical strategy. However, one critical aspect is to encapsulate the complexity of a city and support accurate, cross-scale and in-time predictions based on the ubiquitous spatio-temporal data of high-volume, high-velocity and of high-variety.To address this challenge, MARVEL delivers a disruptive Edge-to-Fog-to-Cloud ubiquitous computing framework that enables multi-modal perception and intelligence for audio-visual scene recognition, event detection in a smart city environment. MARVEL aims to collect, analyse and data mine multi-modal audio-visual data streams of a Smart City and help decision makers to improve the quality of life and services to the citizens without violating ethical and privacy limits in an AI-responsible manner. This is achieved via: (i) fusing large scale distributed multi-modal audio-visual data in real-time; (ii) achieving fast time-to-insights; (iii) supporting automated decision making at all levels of the E2F2C stack; and iv) delivering a personalized federated learning approach, where joint multi modal representations and models are co-designed and improved continuously through