RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'FEAST Extension, Enhancement and Demonstration project'.

assistant: **Innovation**

This project seeks to maximise the likelihood that opportunities for attractive and feasible research cooperation exploiting Australian capability of benefit to Europe are used effectively. It also seeks to maximise the likelihood that Australian researchers can exploit attractive and feasible cooperation opportunities with the far larger European research, development and demonstration effort.  This will be achieved by: (a) clarifying and widely communicating information on competitive Australian research, development and demonstration capabilities in key thematic areas via a Thematic Collaboration Roadmaps work package; (b) identifying and widely communicating best practice strategies and tactics that enable Australian and European researchers to engage effectively via a Best Practice Strategies and Tactics work package; (c) liaising with Member States, other European nations, the European funded Europe Centres in Australia and other FEAST-type units in other nations in order to exchange information and experiences on maximising the effectiveness of this type of facilitation via a Liaison work package; (d) clearly and verifiably demonstrating the additionality of this research cooperation facilitation function via developing an Impact Monitoring System.  Via these actions the project will address expected outcomes in the activities of international cooperation within FP7 by: improving the process of providing information on programs and funding designed to promote cooperation between Europe and Australia; better identifying and demonstrating mutual interest and benefit in S&T cooperation between the EU and Australia, and; sharing best practices via joint workshops and presenting the best prospects for cooperation in particular fields. In so doing, the project will ext
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart Panels for SAT Aircrafts Cabin Insulation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

SPAIN Project main goal is to move from the current design of the fuselage insulation  for small aircraft towards an innovative concept that considers insulation as a characteristic provided by the cabin lining panels. More than researching new and innovative materials for applications in aircraft cabin insulation(because such a solution could require a long certification  process that could deviate the project from the focused TRL)SPAIN Project aims to be innovative in terms of insulation blanket construction methods for coupling the best thermal and acoustics characteristics and in cabin insulation system design methodologies suited for SAT community.SPAIN Project aims at researching a cabin insulation system that limiting the increase of the  acquisition cost, when referred to standard insulation system for small aircraft, at  5% and that having at least the same weight per square meterof the present similar cabin insulation systems used on SAT aircrafts, will have the following expected targets: Reduced cabin noise; Improved accessibility and reduced maintenance cost linked to the insulation system removal; Improved installability and reduced use of installation means with benefits on total final cost.In addition the solution will push at the highest standards the requirements for thermal insulation and acoustic for small aircraft in order to have low weight solution, innovative materials and technology available at a relative low cost for SAT community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of extracellular miRNAs in T cell development, TH2 cell differentiation and TH2 cell-mediated effector function' (2014-2020) under Horizon 2020.

assistant: **Objectives**

It is estimated that more than 200 million Europeans suffer from at least one type of allergy. This condition is elicited by an hyper-activated type-2 inflammatory response coordinated by T helper (TH)-2 cells. In spite a good insight into the molecular mechanisms that triggers TH2 cells activation, the lack in understanding their post-transcriptional regulation is hampering the access to new potential therapeutic targets to curtail the allergy epidemic.Micro-RNA (miRNAs) are regulatory molecules essential for life, which play a fundamental role in shaping cellular functions via post-transcriptional repression of the cellular transcriptome. Though previously considered to operate exclusively inside the parent cell, it is now acknowledged that miRNAs can exit cellular boundaries and control transcription in bystander cells. We recently reported that regulatory T (TREG) cells secret specific miRNAs to repress TH1 cell-mediated immunopathology, and ameliorate a mouse model of autoimmune disease.In this proposal, we will address the role of extracellular miRNAs for the normal T cell development and during allergic inflammation of the airways. To this end, we produced a novel animal model that allows - for the first time - to selectively ablate the activity of extracellular miRNAs in T cells. We will use biochemical, RNA-sequencing and bioinformatics analysis to identify the molecular mechanisms for miRNAs sorting to exocytosis and to identify the miRNAs transferred to and from TH2 cells. This proposal will significantly expand our understanding of transferred miRNAs in the contest of health and disease, and will uncover novel cellular pathways to exploit as therapeutic targets.


**Keywords:** extracellular miRNAs, T cell development, Allergy, Helminth infection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Detection and analysis of nutrient limitation in coastal plankton communities across a hierarchy of temporal and physiological-systemic scales' (DANLIM).

assistant: **Concept**

DANLIM tests the applicability of new fundamental scientific knowledge in decision-making and management of anthropogenic nutrient load in coastal systems. We use a variety of state-of-the-art methods and their advancements, ranging from fluorometric techniques on a single cell level to various aspects of community level nutrient responses in mesocosms. The physiological-demographic mechanisms controlling natural phytoplankton populations are analysed with a new theoretical model. All promising methodological and theoretical results (including empirical bioassay models) will be deployed in an annual monitoring program to test their suitability as tools for coastal zone management. Our main deliverable is Guidelines for Monitoring Nutrient Limitation in Coastal Waters, promoting evolution and unification of European monitoring programs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Computer controlled tensile testing machines: validation of european standard en10002 part 1' to be submitted under Fifth Framework.

assistant: **Abstract**

The revised Standards EN 10002 Pt1 & Pt5 covering Room and Elevated Temperature Tensile Testing of Metals respectively, now recognize the dominance of computer controlled test machines but the systematic technological evidence on which such Standards should be based is not currently available. This project addresses the deficiency and focuses on the requirements outlined in Dedicated Call 10/99 Topic II.2. The project will develop ways to validate software used to determine the relevant material parameters, including Young's Modulus, Proof Stress, Tensile Strength and Elongation at Fracture. In addition recommendations on test machine control methodology suitable for incorporation into the Standards will be produced together will Tensile Data sets in ASCII format suitable for calibrating test machines. The proposal is entitled ' TENSTAND' from the words Tensile Standard.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CLinical impact through AI-assisted MS care' in the context of a Horizon Europe call.

assistant: **Objectives**

Multiple sclerosis (MS) is a devastating immune-mediated disorder of the central nervous system. Since there is no cure available yet for MS, the primary therapeutic goal for MS patients is to slow down disability progression and to reduce relapses at early stages of the disease. Despite 19 available disease modifying treatments (DMTs), the large heterogeneity of the disease, further complicated by the high prevalance of comorbidities and multipharmacy, and the limited understanding of the working mechanisms DMT thereon results in a poor and variable treatment response in a real-world setting. The CLAIMS project is a public-private partnership aiming to address this and make precision medicine for MS patients a reality through data-driven prognosis and treatment advice, in order to better slow down disease progression and eventually conversion to progressive MS. We will develop, validate and submit for regulatory approval a companion diagnostic platform, which offers the MS care team a holistic view of the patient through the visualization of the clinical and subclinical biomarkers and the prediction of the expected disease trajectory under different treatments. For biomarker extraction and treatment prediction, state-of-the-art technologies that allow a reliable and scalable implementation across the world will be used. We believe this platform will initiate the paradigm shift from a trial-and-error, experienced-based treatment of MS patients to a first-time-right, value-based holistic treatment management, and will, hence, improve patient outcomes at a lower total cost of care, enhance patient experience and improve the well-being of the care team.


**Keywords:** Multiple Sclerosis, companion diagnostics, relapse, comorbidities, AI, DMT, efficacy, treatment, deep-lea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Promotion of Clean Energy Technology Initiatives in India Sub-Continent and Asian Region', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective of the proposal is to host the OPET-Associate for the Indian sub-continent and the ASEAN region (ICAS), to service needs of three clean energy sector(s), namely: Energy sector(s), namely: Energy efficient technologies and innovation in Industrial units (SMEs), Conventional power generation and Renewable Energy Technologies The proposed OPET-ICAS will carry out the following key services, as an associate member Assessing the real market needs to encourage the utilisation of clean and energy efficient technologies Result oriented tasks that respond to these needs by using internet/web based networks, assessment and evaluation studies, workshops and conferences -Use of electronic media and internet-based network for information exchange.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Supporting European Industry Success Maximization through Empowerment Centred development' (SEISMEC) targeting Horizon Europe.

assistant: **Abstract**

SEISMEC will demonstrate an empowered, human-centred and ethical development of digital and industrial technologies in 17 pilots in 19 companies from 14 countries across 14 industrial ecosystems. It will do so through a two-way engagement in the development of technologies, empowering end-users and workers, and supporting social innovation, in a process labelled the SEISMEC shift. It will contribute to increased inclusiveness, by supporting a human-centred approach to technology development that is aligned with European social and ethical values (including gender and intersectional aspects). The benefits of human centrism will be measured in Creativity, Collaboration, Autonomy, Automation, Productivity, Privacy, Safety and job Satisfaction, the CAPS empowerment factors for human-centrism.SEIMSECs two-way engagement introduces technical innovations such as explainability, co-development, feedback methods and interfaces to enhance human centrism, but also incorporates plans, needs and innovations from companies and their workers steering them towards an empowered human-centric Industry 5.0 path. The consortium brings together institutions at the forefront of engineering, computer science, networking and exploitation, coordinated by a world-leading social sciences and humanities university, and building up on groundbreaking European projects on industrial innovation.  SEISMEC pilots are representative of all sectors and company sizes, and most European countries and worker roles. Every industrial enterprise in Europe will be able to see some aspect of their activity reflected in SEISMECs pilots and will be able to learn from the project’s outputs through an active campaign of cross-sector empowerment practices exchange. With a strong engagement of European, national and lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Non-linear temporal dynamics of mutually inhibiting pyramidal cells: underlying mechanism for bi-stable perception and disambiguation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Bi-stable perception has been the key tool to investigate how retinal information reaches consciousness. In existing theoretical work to explain this phenomenon, it has been assumed that a neural circuit, called mutual inhibition, plays the key role in perceptual alternations. Two neurons (or neuron groups) representing competing percepts inhibit each other and one becomes dominant while another becomes suppressed. Adaptation of the dominant neuron and recovery of suppressed neuron causes the reversal of the dominance after few seconds. While there are elaborate theoretical models implementing this circuit, its physiological data from real neurons is missing. I will use in vitro preparation combined with a state-of-art “dynamic clamp” system where the disynaptic inhibitory connections between two real pyramidal cells are established by model synapses and inhibitory neuron models. I will run paradigms equivalent to experimental paradigms known in the research of bi-stable perception. In this way, I aim at elucidating the neurophysiological factors underlying the known dynamical properties of bi-stable perception. I will investigate how dominance durations and their distributions are influenced by the activity levels of the two neurons (equivalent to the well-known Levelt’s propositions), how their stochasticity is influenced by noise, how memory effect can be observed, and how feedback projection influences their dynamics.There is often an ambiguity in input images due to noise or conflicting information. Coherent representation of such input can be established if the mutually inhibiting neurons representing conflicting cues are influenced by feedback such that the neural signals consistent with global properties are enhanced. Therefore, mutual inhibition may work as a f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Virtual heat treatment tool for monitoring and optimising ht process' (VHT).

assistant: **Concept**

The objective of the VHT project is to provide designers of steel parts and companies performing heat treatment with a Virtual Heat Treatment software (so called in this project Decision Support System DSS), able to:- Predict distortion resulting from carburising, nitriding and quenching of steel parts both qualitatively and quantitatively;- Optimise time and operating condition of heat treatments materials The VHT software to develop is based on a combination of 3 approaches:-Finite Element Analysis -Knowledge Based System (KBS);- Databases (Material & Generic)18 partners, from 4 IMS regions (Europe, Japan, Korea, Canada) joined this project and will bring their know-how in the field of simulation of Heat Treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SYSTEMS BIOLOGY OF PATHWAYS INVOLVING BRAIN AGEING' (AGEDBRAINSYSBIO).

assistant: **Innovation**

In spite of valuable approaches applied to get a broad understanding of genetic, epidemiologic and molecular and system-level biological principles of human aging, cognitive decline remains as one of the greatest health challenges of the old age, with nearly 50% of adults over 85 afflicted of Alzheimer’s disease. Furthermore, drug development has not performed as expected in clinical trials, at least in part because of an insufficient mechanistic understanding at the systemic level in human. AgedBrainSYSBIO is a timely and straightforward project based on the integration of available transcriptomics, proteomics and metabolomics data, addition of relevant novel sets of data, their modeling and experimental testing in both human, mouse and drosophila. The concept is to identify subsets of pathways with two unique druggable hallmarks: (i) the validation of interactions occurring locally in subregions of neurons and (ii) a human and/or primate accelerated evolutionary signature, using six interacting approaches: (1) the identification of interacting protein networks from recent Late-Onset Alzheimer Disease- Genome Wide Association Studies (LOAD-GWAS) data, (2) the experimental validation of interconnected networks working in subregion of a neuron (such as dendrites and dendritic spines), (3) the inclusion of these  experimentally validated networks in larger networks obtained from available databases to extend possible protein interactions, (4) the identification of human and/or primate positive selection either in coding or in regulatory gene sequences,(5) the manipulation of  these human and/or primate accelerated evolutionary interacting proteins in human neurons derived from induced Pluripotent Stem Cells (iPSCs) and modeling prediction challenged in drosophila and nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pushing the Frontier of Heterogeneous Agent Macro: Expectations Formation and Economic Crises', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

One of the key developments in macroeconomics research over the last three decades has been the incorporation of explicit heterogeneity into models of the macroeconomy. But one of the all-time biggest questions in macroeconomics has so far been out of reach for this approach: why do developed economies experience infrequent but large economic crises? This is due to a problematic feature of current heterogeneous agent (HA) models: the assumption of rational expectations means that agents forecast prices by forecasting distributions resulting in the entire cross-sectional distribution entering their decision problem. This extreme version of the curse of dimensionality hugely increases the models’ computational complexity.HA-FRONTIER aims to overcome this problem by developing alternative approaches to the rational expectations assumption. I will adapt ideas from the literature on reinforcement learning in psychology and computer science (temporal difference learning) to better model how agents form expectations about future prices. I will incorporate key empirical evidence on expectations formation, e.g. from the large literature on survey expectations. Departing from rational expectations thus “kills two birds with one stone”: it makes HA models with aggregate risk operational while, at the same time, making them more realistic. Finally, I will put this methodology to use to develop an empirically grounded macroeconomic theory of infrequent but large economic crises that incorporates asset-price booms driven by individuals reallocating their portfolios toward bubbly assets and crashes driven by the reverse movement.To disseminate the ideas developed by HA-FRONTIER, I will write a PhD-level textbook on heterogeneous-agent macroeconomics. Such a textbook is currently missi