RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enhancing microfabricated devices with chemical imaging for novel chemical technology' to be submitted under Seventh Framework.

assistant: **Abstract**

The development of microchemical systems is one of the most exciting recently developed research topics with numerous potential industrial applications. One of the greatest challenges to encourage these systems to be adopted by industry is successful high level integration with sensors for understanding, optimisation and control of microsystems for various processes. The proposed research will develop such systems and their integration via linking them with chemical imaging. The benefits of chemical engineering at smaller lengthscales are manifold; the design of microchemical processes is important where, by nature, it is essential to have microdevices, e.g. in cell biology manipulation and transformations. Other processes can be designed macroscopically, but a move to microprocesses gives process advantages, such as enhanced heat and mass transfer, novel flow regimes, bringing material and process time and lengthscales into the same region to allow material property and process interactions, which would be impossible in macro-reactors. In order to achieve this, it is essential to have the capability of rapid 3D chemical imaging on a nano/microscale, as only by devising these new techniques to image microchemical systems, it will be possible to optimise them for novel engineering. The proposal is aimed at providing chemical imaging capability to miniaturised devices for the engineering of new materials and processes. It is proposed (i) to use chemical imaging and micro-deposition methods for the generation of materials with responsive gradient structures; (ii) to engineer nanostructured materials aided by high-resolution chemical imaging; (iii) to combine microfluidics with chemical imaging as a prototype of miniaturised chemical factories. The overall aim is to utilise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chemoenzymatic glyco-engineering of therapeutic monoclonal antibodies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Monoclonal Antibodies (mAbs) have gained an important place in the therapeutic arsenal of anticancer drugs. mAbs are glycoproteins containing a conserved N-linked glycosylation site at residue Asn297 of the fragment crystallisable (Fc). Most of the mAbs approved by the EMA are commercialized as a complex mixture of glycoforms at this site. It is well stablished that the precise chemical structure of the N-linked glycan modulates the effector functions mediated by the Fc domain. Specifically, for cancer treatment applications, the lack of fucose on the glycan structure contributes to enhance the effector functions of the antibodies, via increased affinity of IgG1 for FcgRIIIa on immune cells. New strategies to glycoengineering mAbs with homogenous glycoforms and lacking fucose core on their glycan structures have become a priority for the biopharmaceutical industry in order to obtain “biosuperior” anticancer drugs. Here, we will engineer a novel fucosidase enzyme that can act on fully glycosylated mAbs in order to simplify the chemoenzymatic synthesis of antibody drugs, based on the host laboratory expertise in Carbohydrate Active Enzymes. We will address three specific aims: (1) to define the structural basis of EndoS antibody specificity; (2) to elucidate the molecular mechanisms of IgG defucosylation by AlfC; and (3) to engineer an enzyme with fucosidase activity and specific for IgG. The GlycoMabs project will provide me an excellent and unique career opportunity by learning new skills in structural biology, protein engineering and project management which will grant me a leading independent position. Moreover, I will explore the industry interest in the application of our novel enzymes to generate homogeneous and afucosylated antibodies through an intersectoral seco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'FOAM ASSISTED WAG' to be submitted under Fourth Framework.

assistant: **Abstract**

The purpose of this project is to demonstrate technology, based on mobility control of WAG injection by foam. The demonstration will be done in the Snorre Field, which is a stratified, heterogeneous reservoir with permeability contrasts and presence of high permeable thief zones, and as such represents a typical North Sea reservoir. The projects aims to reduce the technological and economical risk of using this technology on a general basis by validating the results derived from laboratory tests, computer simulations and related small scale field tests, by a realistic field size demonstration, and, based on that, prepare general guidelines for design of subsequent full scale operations on target and other oil fields. The technology has a potential for use in a number of North sea reservoirs, including marginal fields which does not have a gas export solution, and where the associated gas must be re-injected.L%During the ongoing design phase, the following achievements/decisions have been made:- Target reservoir zone has been identified as Upper Statfjord Formation- An updated reservoir description is established, based on previous reservoir data and history matching of production data from target area.- Reservoir models have been established based on the updated reservoir description: element model for the target area, and radial models centred at the injection well. The models are used in the design of the injection program, and will be used as a working tool during the injection phase and subsequently for evaluation of projects results.- The stars simulator from CMG is used for reservoir simulations with foam. The simulator has been refined, and foam parameters have been established from laboratory and field data.- The model has been used to assess the added extractio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Greening the polyurethane industry through versatile and low cost eco-polyols' under Horizon 2020.

assistant: **Concept**

Polyurethane (PU) is one of the most popular plastic in the world and is everywhere around us, from our car’s seats to the insulating material used in our homes and clothes. Every year more than 23 million tons of PU are produced from two raw materials coming from oil refining: polyols and isocyanates. This is posing relevant concerns to PU manufacturers, especially because their customers are “going green”, avoiding the use of oil-derived product as much as possible. Eco-polyols have long been seen as a solution to these issues, driving a steep growth of the green polyols industry. However, bio polyols are only adequate for specific applications and their price (>2€/kg) make them suitable only for high-end solutions. To capture this huge market opportunity, at PolyLabs we have developed ECO-POL, a novel eco-polyol obtained from renewable raw material and from low grade PET which is otherwise impossible to recycle. The combination of our proprietary autocatalytic process with extremely low cost raw materials allowed us to demonstrate the feasibility of an extremely versatile polyol which can replace oil-based ones in practically all applications. And at the same market price (1.4 – 1.5 €/kg). Through this SME Instrument project we plan to scale up our process and manufacturing capacity to meet the needs of the European PU industry, targeting an initial production of 10,000 – 15,000 tonnes/year which will be replicated in several countries as long as the local market demand grows. We are an innovative chemical company established in close partnership with the scientific Institute of Wood Chemistry of Latvia (IWC) to produce bio-based polyol for the PU industry, and we are already commercialising more than 300 tons/year of our first generation eco-polyols. Through this in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Substantiating the safety of systems containing knowledge based components' under Fourth Framework.

assistant: **Concept**

Many results have been acquired over the last few years in the design, development, test, verification and validation of KB systems. But these results have not been systematically taken into consideration from the operating safety and quality aspects. This is due to the wide cultural difference between those who use knowledge-based systems, those who develop them, and those responsible for safety, certification and software quality.The overall objective of Safe-KBS is to demonstrate the feasibility of extending knowledge based systems (KBS) markets to safety critical systems, by providing means of developing the KB components of safety critical systems, and guaranteeing the quality of these KB components, as required for the certification of these systems. The project will be based on requirements resulting from three real-size applications in the domains of air crew decision aid, nuclear energy production and sea transportation. The project aims at producing usable results tested via the partial re-engineering and simulated certification of the first two.The project objective will be satisfied in three phases:- Analysis of operating safety on a set of representative functions (for each of the three applications).- Development of a suitable methodology (building, among others, on Common KADS) to control the identified risk, taking into account the adaptation of this methodology to the existing base of development tools, and the definition of complementary tools.- Partial simulation of the certification process for these applications, applying the methodology and the tooling base (for the air crew decision aid application and the nuclear energy production application).The main results will be:- A methodology for developing high quality KB components embedded in safety cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Strategies for the prevention and treatment of prion disease (EU-PRIONS)' (EU-PRIONS), addressing dissemination and exploitation.

assistant: **Impact**

Exposure of the EU population to the BSE prison strain raises serious concerns that a major epidemic of variant CJD will follow. The possibility of estrogenic transmission of pre-clinical disease by blood products and surgical instruments poses further challenges. In view of this, development of post-exposure strategies against prison disease is mandatory. As an established European consortium, we propose an integrated multi-disciplinary approach to achieve this. We will validate our existing transgenic mice as standardised in vivo models of human prison disease to evaluate the effect of candidate therapeutics on central and peripheral pathogenesis. We will explore novel biochemical, cellular and immunological targets of intervention. Because of the extremely prolonged incubation periods of prison disease in humans, there is a window of opportunity to develop treatments to abort such an epidemic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Testing Cyber-Physical Systems under Uncertainty: Systematic, Extensible, and Configurable Model-based and Search-based Testing Methodologies'.

assistant: **Innovation**

Uncertainty is intrinsic in Cyber-Physical Systems (CPSs) due to novel interactions of embedded systems, networking equipment, cloud infrastructures, and humans. CPSs have become predominant in critical domains and necessitate the implementation of proper mechanisms to deal with uncertainty during their operation at an acceptable cost avoiding unwarranted threats to its users and environment. One way to guarantee the correct implementation of such mechanisms is via automated and systematic Model-Based Testing (MBT)—a way of improving dependability.U-Test will improve the dependability of CPSs by defining extensible MBT frameworks supporting holistic MBT of CPSs under uncertainty in a cost-effective manner. More specifically our objectives are: 1) Provide a comprehensive and extensible taxonomy of uncertainties classifying uncertainties, their properties, and relationships; 2) An Uncertainty Modelling Framework (UMF) to support modelling uncertainties at various levels relying on exiting modelling/testing standards; 3) Defining an intelligent way to evolve uncertainty models developed using UMF towards realistic unknown uncertainty models using search algorithms (e.g., Genetic Algorithms); 4) Generating cost-effective test cases from uncertainty and evolved models. U-Test consortium encompasses domain experts from various facets of CPSs, i.e., software, embedded systems, distributed systems, and cloud infrastructure. We have chosen two case studies from diverse domains including Handling Systems and Geo Sports to assess the cost-effectiveness of U-Test. The solutions will be integrated into two key commercial tools available in the market: ModelBus/Fokus!MBT and CertifyIt. Moreover, the solutions will be deployed into the actual practise in addition to standardization to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unifying Cloud and Carrier Networks' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Telecom providers struggle with low service flexibility, increasing complexity and related costs. Although cloud computing and networking have been two very active fields of research, there is currently little integration between the vast networking assets and data centres of telecom providers. UNIFY addresses this by considering the entire network, from home networks up to data centre, as a unified production environment". The unified approach will open up the potential of virtualization, programmability / automation to span across the whole infrastructure of the provider and guarantee an unprecedented level of agility for network operations and for deploying new, secure and quality of experience aware services, seamlessly instantiatable across the entire infrastructure. This will lead to a novel service-oriented carrier-grade platform for the Future Internet and brings virtualized services in the most efficient, secure and quality-aware way to the end-users.UNIFY focuses on enablers of such unified production environment and will develop an automated, dynamic service creation platform, leveraging a fine-granular service chaining architecture. A service abstraction model and a proper service creation language will enable the dynamic and automatic placement of networking, computing and storage components across the infrastructure. A global orchestrator, which novel optimization algorithms, ensures the optimal placement of the elementary service components across the entire infrastructure. New management technologies, based on experience from data centre and tightly integrated into the service orchestration architecture, will be developed and cope with the dynamicity of new services. The applicability of a universal network node based on commodity hardware will be evalua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Surface modification & optimization of gas nanoelectroceramics-based sensor systems' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content Increasing public concern over environmental issues. along with a growing industrial need for well-controlled atmospheres. demand the development of progressively more advanced reliable and largely maintenance-free gas sensor and monitoring systems. The first and overall objective of the presently-proposed multidisciplinary project is to offer a European challenge to current Japanese supremacy in the field by developing flexible fabrication processes for high-quality selective solid-state sensors. Beginning with the proprietary thick-film technology of one of the consortium members the second objective is to optimize a complete low-cost carbon dioxide sensor along with its associated electronics. This will culminate in an industrial prototype so ensuring rapid technology transfer. The consortium inolves committed industrial and academic partners having a wide range of complementary expertise and expects to achieve these goals via a rigorous intvestigation into the relevant gas/ceramic surface interactions so as to understand and master the complex phenomena involved, some of which are responsible for the dramatic degradation of current sensors. Incremental multicriteria optimization based on powerful surface science and catalytic techniques will play a key role in this proposed highly-focussed research strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Science in the City' (SitC) under Horizon 2020.

assistant: **Objectives**

Science in the City is a Science and Arts Festival. Malta's Capital City, Valletta, on ERN is filled with researchers from all scientific fields, experiments, performances, art installations, games and much more to attract some 30,000 people. This EFFE award winning, national event has been visited by 42% of Malta's population at least once over the past 8 years. It educates, enthralls and excites people of all ages. It inspires creativity, nurtures curiosity and a passion for knowledge in children, youth and adults across the country. The festival supports the idea of RRI and uses its activities to explain the concept and bring researchers closer to the publics.


**Keywords:** Engagement, enable empower, science, researchers, careers, arts, creativity, education, fun, RRI, Active Citizens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A measurement of the gluon density of the proton at hera' in the context of a Fourth Framework call.

assistant: **Objectives**

The purpose of the research is the measurement of the gluon density inside the proton. Its knowledge in the new region available at the HERA energy is fundamental for the description of the proton. This is important by itself to understand the interactions inside the proton and also in view of the physics at the next proton-proton collider at CERN, the LHC, where the dominant processes will be described by interacting gluons. The method to carry out the measurement relies on the direct dependence of the heavy quark production on the gluon content of the proton, in the mechanism of photon-gluon fusion, dominant at HERA. In particular the studies of the J/Psi and Open Charm production will allow a statistically very significant determination of the gluon density in the relevant region of invariant fraction of the proton momentum between 5 X 10**-4 and 5 X 10**-1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'New building materials by recycling of wastes of foundry moulding sands, and demolition scraps'.

assistant: **Innovation**

The accumulation of wastes of foundry moulding sands, as well as of wastes of concrete demolition scraps after recycling of coarse aggregates, raise an important problem of stocking or of reuse to foundries and demolition contractors with respect of ecological rules and of obligations in favour of environment protection. The present research project aims at the study of reemployment abilities of these wastes in favour of the production of new building materials complying to standards, and on the bases of calcic silicatisation process, the wastes being treated and mixed with anhydre lime, and then cured in autoclave. This treatment of which feasibility must be controled, can offer a recycling way including the fixation of eventual polluting elements. The end products could be various materials such as traditional silico calcic bricks (solid or hollow), wall elements or facing panels. The project includes pilot operations of production at different levels of performances.