RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The industrialization and market entry of a novel bioengineered hydrogel grid to standardize stem cell cultures for precision medicine.' in the context of a Horizon 2020 call.

assistant: **Objectives**

The ability to generate miniature organ models in a dish, termed organoids, from patient stem cells has opened endless possibilities for applications in precision medicine. SUN bioscience SA, a spin-off company of EPFL in Switzerland, was founded in 2016 with the ambition to move these organoid cultures from basic research to the Health Care industry. To reach this goal, SUN bioscience has developed Gri3D, a microstructured biocompatible hydrogel platform, and aims to establish this technology as a new standard for growing organoids at industrial scale and precision. Gri3D prototypes have been field tested with over 30 European academic and pharmaceutical R&D groups. In addition, SUN bioscience has developed an industrial automated manufacturing mechanism for Gri3D that is now being translated into the world-wide first machine, Hydra I, that auomates liquid handling with hydrogel microembossing.The objective of this feasibility study is to verify the technical, economical and practical viability of Gri3D and to ensure its successful market entry in Europe. Specifically, the first step is to validate the production capacity of Hydra I by producing 1’000 Gri3D units, which corresponds to one tenth of the total annual target production volume.In a second step, SUN bioscience aims to validate the market by commercializing these 1’000 Gri3D units to existing customers and to expand its customer base to a total of 20-40 recurrent clients.According to our current strategy, SUN bioscience will run at maximum single line production capacity with cumulative revenues of >€2M within 3 years after market introduction of Gri3D. The 3D technologies market is expected to reach €600M by 2021. The long-term business objective is to implement organoid assays on Gri3D and to establish SUN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rethinking digital copyright law for a culturally diverse, accessible, creative Europe' under Horizon 2020.

assistant: **Concept**

Technologies enable unprecedented democratization of cultural practices and the production and use of IP. The creation of an effective system of sustainable norms for digital copyright is a major challenge due to four phenomena: copyright complexity, sidestepping, knowledge gap, and awareness gap. With its multi-disciplinary approach, bringing together researchers, practitioners and stakeholders, reCreating Europe will deliver ground-breaking contributions towards a clear understanding of what makes a regulatory framework that promotes culturally diverse production, and optimizes inclusive access and consumption. First, reCreating Europe yields unprecedented cross-national maps of (i) multi-level regulatory responses that impact access to culture, cultural production, competitiveness of creative industries, and (ii) coping strategies of stakeholders vis-à-vis IPRs pitfalls and constraints. Second, it develops innovative qualitative and quantitative methods to measure the impact of digitization on the production and consumption of cultural goods and services. Changing intermediaries, specific creative communities, micro/SMEs and vulnerable users get special attention. Third, reCreating Europe performs a legal and technological mapping and evaluation of TPMs and content-filtering algorithms, and their impact on cultural diversity, access to culture and the generation of cultural value. Last, it offers policy recommendations and best practices, aimed at democratizing culture while reinforcing the sustainable development of rich and diverse cultural/creative industries. reCreating Europe’s unique comprehensive focus on five key groups of stakeholders -individual authors and performers, creative industries, cultural and heritage institutions, intermediaries, end-users- allow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The effect of Plasmodium GPIs on mammalian cells and its role on the course of malaria infections', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Malaria is responsible for more than 2 million deaths amongst children every year. As the mortality rate of 20-30% for severe falciparum malaria under even the best clinical conditions testifies, access to anti-malarial drugs is not sufficient to prevent an appreciable mortality from this disease. Understanding the cause of death at a cellular level is essential if additional rational treatments are to be developed. Most vaccine efforts are aimed at immunity against infection (antiparasitic) by targeting p arasite proteins. However, it has long been suggested that understanding the factors associated with resistance to severe clinical manifestations (anti-disease immunity) would lead to alternative approaches for malaria control. In these regard, parasite gl ycosylphosphatidylinositols (GPIs) appear to offer new opportunities. GPIs are a distinct class of glycolipids found ubiquitously in eukaryotic cells and implicated in several biological responses. GPIs are particularly abundant in parasites where they are found as free lipids and attached to proteins. In intraerythrocytic P. falciparum, GPIs represent the major glycoconjugates. P. falciparum GPIs have been identified as malaria pathogenicity factors based on their ability to induce inflammatory cytokines i n macrophages and cause symptoms reminiscentent of acute malaria infectionin experimental animals. We propose to determine the effect that Plasmodium GPIs have on this host mammalian cells and the importance of the GPIs role on the course of a malaria infe ction. We strongly believe this project will highly increases our possibilities of finding targets for pharmacological treatments of the disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Characterising protein oligomers and their role in neurodegenerative disease in humans'.

assistant: **Concept**

Small soluble protein aggregates play a key role in the onset and spreading of Alzheimer’s and Parkinson’s diseases. However, which oligomers are present in human disease and which are toxic remains unknown because ultrasensitive methods do not exist to detect and characterise the low concentration of oligomers, which are highly heterogeneous in size and structure. To address this problem we will develop fluorescence based methods to detect and characterise individual oligomers to measure the oligomer size, structure, proteinase K resistance, seeding capability and composition. We will also develop methods to enrich these oligomers so we can use mass spectrometry to determine post translational modifications and recover the oligomers to directly test their cytotoxicity and mechanism of damage. The capability to characterise these oligomers at this unprecedented level of detail will represent a major advance in the field. These methods will then be applied to stem cell models of Alzheimer’s disease and Parkinson’s disease and then clinical samples of CSF from patients. These experiments will determine how the number, composition or structure of the oligomers changes in the disease and if this results in increased cytotoxicity. Clinical samples of CSF from patients with genetic mutations will be used to determine if detectable changes in the oligomers occur early in the disease and samples of brain tissue used to determine the changes in oligomers during the spreading of the disease.By the end of the project we will have determined which oligomers play major roles in the onset and spreading of Alzheimer’s and Parkinson’s disease in humans, providing targets for therapies, and tested if the detection and characterisation of these oligomers can be used for early diagnosis o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Epigenetic mechanisms underlying the influence of paternal drug experience on offspring behavior'.

assistant: **Concept**

The idea of transmitting paternal environmental impact across generations has been indicated and described in studies across species, but the mechanism is still unclear. The overall aim of the project is to test whether H3K27me3, a type of epigenetic modification on histone 3 [1], is involved in transmitting environmental impact across generation to influence the behavior of offspring. With a behavioral neuroscience background, the experienced research (ER) will apply his expertise in high throughput behavioral assay and combine techniques he will learn from the host lab, including epigenetic profiling, NGS, targeted epigenome editing and computational analysis to address specifically whether paternal drug experience influence offspring behavior via modifying H3K27me3 on dopamine-related genes that are involved in various behaviors [2]. Besides advancing our understanding of the importance and mechanism of paternal inheritance and the role of epigenetics in general, this project will also further extend zebrafish as a model in studying cross-generational transmission of environmental experience by combining multidisciplinary techniques. The trainings ER will be beneficial and essential for his future goal to study epigenetic mechanisms underlying physiology and pathology of brain.


**Keywords:** epigenomics, zebra fish, trans-generational epigenetic inheritance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A new approach in curve counting theories and mirror symmetry' (NCMS).

assistant: **Innovation**

A Marie Sklodowska-Curie IF at ETH-Zurich will lead to major developments of the PI's current research.The PI's research focuses on better understanding the mathematical implications of the physical dualities that arise in the study of string theory. Mirror symmetry, which is a kind of duality in string theory, equates two physical theories called the A-model and B-model. Mirror symmetry predicts that the A-model (resp. the B-model) of a space/variety is equivalent to the B-model (resp. the A-model) of itsmirror space/variety. In mathematics, the A-model corresponds to Gromov--Witten (GW) theory, which is one of the first modern curve counting theories in enumerative geometry. To a physicist, a complex curve represents the worldsheet of a string propagating through space-time.In 2018, the PI initiated a new research program which provides a novel approach of using orbifold techniques to count curves in algebraic varieties with tangency conditions along co-dimension one sub-varieties (divisors). This novel approach defines a generalization of relative GW theory which plays a central role in mirror symmetry. Several major advances have been achieved in the past two years and a new research direction has been created.This proposal focuses on this new research program and its applications to curve counting theories and mirror symmetry. We expect to build a firm foundation for our new theory and expand this program along various directions. The proposal is divided into three main projects. The first project focuses on structural properties of the new GW theory and its relation with punctured GW theory. The second project explores applications of the new theory to several aspects of mirror symmetry including Gross--Siebert program, the Strominger--Yau--Zaslow (SYZ) conjecture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'A paradigm shift for the year 2000 European virtual multimodal transport operator'.

assistant: **Innovation**

The capability for transport industry SMEs to exploit new business practices that can allow them to adequately adapt to the quickly changing market appears to be fundamental if they are to resist and compete on the long run. Structural factors such as organisational infrastructure and financial capability represent the major drawbacks to pursuing a competitive policy versus well-established, multi-national Multimodal Transport Operators (MTOs). It is in this context that the idea of a networked enterprise, made-up of tens of SME transport operators, all acting and behaving so to be perceived from the market as one large enterprise, can represent a paradigm shift for thousands of European SMEs, enabling them to act as de facto MTOs within a virtual company.This new business practice can be named Virtual Multimodal Transport Operator (VMTO). A VMTO might then be thought of as being formed by many - as many as needed - independent companies all adopting, to different extents, a common organisational infrastructure, obeying and complying to a well-defined reference model, presenting comparable cultural background and exploiting common IT potential. In this scenario, IT is seen as the strategic enabler of the change.The project proposes two European SMEs that are willing to work-out the VMTO business best practice, approaching the pilot experiment with much determination and commitment. The goal of the Trans2000 pilot is to demonstrate the feasibility of the above proposed VMTO, working to achieve a complete definition of the organisational reference model and advanced IT infrastructure that potential future VMTO members can pragmatically adopt.The Consortium set-up to achieve pilot's goal is composed, besides the two user industries (Intertrasport and ITG), by one major con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'EuroConference on Symbiotic stars probing stellar evolution""'.

assistant: **Objectives**

It is proposed to organise a Euroconference with the title Symbiotic stars probing stellar evolution", to be held on the island of La Palma, Spain, on May 27-31, 2002. Half or maybe two thirds of stars in the Universe are binaries. Among them, symbiotic stars are believed to be important objects not only to understand better stellar evolution in binary stars, but also to discuss phenomena that are relevant to a number of other astrophysical fields. As 5 years have passed since the last international workshop dedicated to the subject, the proposed EuroConference is aimed at revising the state-of -the-art in the field of symbiotic stars, as well as to emphasise, for the first time in a comprehensive way, the links to other branches of astrophysics, such as red giants, planetary nebulae, novae, supersoft X -ray sources and supernovae.To achieve these goals, the scientific programme of the conference is organised so as to have invited review talks which cover all the different subjects related to symbiotic stars and binary stars evolution, and which will be given by leading scientists in each particular field. This will help in strengthening the world leadership that European astronomers had so far in this field, by promoting future collaborative projects, training young researchers, and stimulating new ideas to extend this (mainly European) expertise to other important fields of astrophysics.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00206-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'ICT based System to Predict & Prevent Falls'.

assistant: **Concept**

A demographic transformation is underway with a significant rise in the proportion of people aged 65 and older expected over the coming decades. It is therefore crucial to invest in research aimed at dealing with health challenges of an ageing population.Falls represent a major age-related health challenge facing our society, with about one third of older community-living people falling at least once a year. Falls in older people can markedly change one's health trajectory, have debilitating and isolating consequences and can trigger a downward spiral of disability which can lead to institutionalization and premature death. Falls and fractures account for over half of all injury-related health care costs and have a major impact not only on older people, but also their carers, health services and the community. This impact will grow substantially in the near future due to the increased proportion of older people in the population. The prevention of falls and mobility-related disability among older people is an urgent public health challenge in Europe and internationally.Despite robust evidence and availability of best-practice clinical guidelines to support interventions for preventing falls in older people, implementation of preventive measures remains low, mainly due to the accompanied high cost in both time and resources of the recommended individualized approach. Novel methods for delivery of quality healthcare are required to increase effectiveness of management while containing costs and using scarce human resources to maximum effect. Technology-based solutions have potential to reduce costs while maintaining individualized high quality healthcare. Fall prediction and prevention is a field of research where technology can be used to facilitate healthy ageing, well-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Environmental change and forced migration scenarios'.

assistant: **Objectives**

Forced migration is a movement in which an element of coercion exists, including threats to life and livelihood, whether arising from natural or man-made causes (e.g. movements of refugees and internally displaced persons). The changes of natural and man-made environment will probably be the most significant factors among the causes of forced migration. It is essential to get accurate information about the current and future triggers of forced migration in each country of origin and within Europe itself. The two year long project's general objectives are to support European policies, research and the civil society with'forced migration' scenarios, and cooperate with other migration and environment degradation related projects and institutions. The objectives will be achieved by five interlinked research sequences: 1) forecasting the natural and anthropogenic causes of forced migration; 2) analyzing direct (e.g. desertification) and indirect (e.g. conflicts) environmental effects on livelihoods; 3) predicting potential forced migration flows, with emphasis on environmental refugees; 4) contributing to the preparation of statistical indicators to measure environmental refugee flows; 5) dissemination. The study of the causes is a multidisciplinary and multisectoral process. The list of methodological tools contains all traditional elements of research from primary data collection via statistical analysis and environmental evaluation to modelling. The studied cases are selected from the following regions: Europe and Russia, NIS and Central Asia, Asia, Sub-Saharan Africa and Ghana, Middle East and Northern Africa, Latin America. The project will produce detailed sub-region or country level forced migration scenarios, including environmental refugees; presentation of causes l