RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Catalytic Enantioselective Dearomatisation : A New Strategy for the Synthesis of Complex Bioactive Natural Products', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposal outlines a blueprint towards the development of a new catalytic strategy for chemical synthesis, wherein catalytic cascade processes are designed around the transformation of a common functional motif to a diversity of enantiopure natural product architectures, in a single step. The hypothesis behind the chemo-catalytic synthesis strategy involves the development of a catalytic enantioselective dearomatization (CED) process that directly converts flat aromatic molecules into complex asymmetric structures. The transformation involves a tandem process, comprising oxidative dearomatization and organocatalytic desymmetrization, generating highly functionalized, non-racemic architectures. The natural product targets structures of alkaloids, polyketide, steroid and terpene biosynthetic origin, and complex non-natural frameworks that may have interesting properties, as the basis for novel small-molecule libraries with untapped biological properties. The programme of research will focus on the exploitation and the development of the cascade ‘zipper-reaction’ concept, CED, wherein simple, linear molecules can be directly converted to complex enantiopure architectures that closely resemble the structures of bioactive natural products. The proposal will have four parts over the two-year period of the proposed Fellowship : the method development for the CED cascade process, the total synthesis of morphine and the development of novel scaffolds for drug discovery. The research outlined in this proposal is a representative part of a 'grand challenge' programme to provide a chemo-catalysis blueprint for synthesis that is inspired by the efficacy of biosynthesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Aligned Roll-to-Roll Shear Coating of Nanotubes' (ARENA) under Horizon 2020.

assistant: **Objectives**

Carbon Nanotubes (CNTs) are considered to be one of 21st century’s most promising materials and over the past decade, tremendous scientific advances have been achieved in the synthesis and processing of these materials. However, the uptake of CNTs by high-tech industry is hampered by a lack of high-throughput processes to structure CNTs into aligned and densely packed assemblies. This is key to fabricate next generation CNT devices, and to date, the CNT community is still struggling to achieve this, especially over large areas. As part of the ERC Starting Grant HiENA, we are pioneering a potentially disruptive strategy to control the packing of CNTs and to fabricate large area films of aligned CNT. In this process, we start from newly developed ultra-high density dispersion of CNTs which can form liquid crystal domains. These domains are aligned by controlling shear in a custom designed coating head which then continuously dispenses the CNTs on a roll-to-roll coater which was recently purchased by the host group. To quantify the performance of the proposed technology, the parameter space of the coating process will be mapped out in terms of throughput, film thickness, uniformity, and conductivity. Finally, we devised a two-step commercialisation plan which targets less to more demanding markets including thin film heaters, ultra-lightweight electro-magnetic shields, as well as interconnects and sensors for flexible electronics. We believe this project is timely on the one hand because of the technology push of improved CNT processing and on the other hand by the pull from several new markets including flexible electronics and the rise of the Internet of Things which will require a drastic increase in low cost electronic manufacturing technologies. The ERC Proof of Conce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'ForestFireAI: Large-scale Prediction of Forest Fire Drivers from Space Using Multi-source Remote Sensing Data and Artificial Intelligence Techniques'.

assistant: **Objectives**

With the increasing frequency and intensity of forest fires, it is essential to better understand the drivers causing them. Identifying forest fire drivers offer valuable insights that can enhance our comprehension of forest fire variability and guide targeted regional risk management strategies. Recent advancements in satellite remote sensing and machine learning data processing techniques have significantly improved fire monitoring. However, while these efforts have resulted in accurate fire maps, they do not provide information about the underlying causes. Consequently, the full potential of Earth Observation data, along with advanced data processing and modelling techniques for studying the forest fire drivers, remains largely unexplored. The ForestFireAI project aims to leverage the availability of multi-source and multi-temporal Earth Observation data to propose new AI algorithms for estimating forest fire drivers. This includes creating a benchmark dataset of forest fire drivers in Europe, which will serve as a ground truth data for evaluating developed advanced AI algorithms. Moreover, the project will focus on developing AI techniques to improve the spatial resolution of data, use multi-source data and their temporal resolution, and establish efficient processing schemes for detecting forest fire drivers, such as human activities, high temperature, fuel, and dryness. To ensure the reliability, efficiency, and scalability of the developed algorithms, uncertainty-aware, explainable, and hybrid physical/data-driven techniques will be incorporated. Through this multidisciplinary approach—bringing together expertise in remote sensing, computer science, and forest ecology—ForestFireAI will take important steps toward developing the algorithms necessary for better und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Demonstration of a sustainable CHP concept using residues from olive oil production'.

assistant: **Objectives**

The project focuses on the demonstration of an innovative and sustainable CHP concept using residues from olive oil production (olive wastes) as fuel. A first plant based on the new concept will be realised in Greece. The main objective of the project is to demonstrate a closed cycle concept able to reduce landfill problems and emissions and to promote the use of renewable electricity production in Southern Europe. The project will be based on an approach integrating the whole chain (fuel logistics and preparation, energy production, by-product utilisation).An optimised fuel logistic concept will guarantee for a secured fuel supply over the whole year. The fuel will not only be dewatered and dried but also a marketable by-product will be produced. By this means a better fuel quality can be achieved and solid wastes as well as waste- water can be omitted. The development and design of the combustion unit focuses on a technology tailored to the special characteristics of the olive waste.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Light Assisted-CRYStallization' (LACRYS) under Horizon 2020.

assistant: **Objectives**

The objective of the LACRYS project is to validate and de-risk a technology based on light assisted crystallization for restoration of artworks (frescos), to assess its market potential and identify the most suitable exploitation strategy. Precipitation or dissolution oThe precipitation or dissolution of single and composite materials is a ubiquitous process in materials science and nature. So far, it can be controlled at large scale either in laboratory experiments or industrial processes. However, controlling the precipitation (or dissolution) of a mineral phase at micron scale is nowadays a challenge opening the gate to precious applications in health sciences (bone and teeth repair), art preservation (frescos and most pieces of work), the synthesis of advanced complex materials and the polymorphic control in pharmaceutical industry. We have envisaged a new, feasible and affordable method to control the precipitation/dissolution of mineral phases at the scale of one micron and below. Our method uses light-sensitive molecules that can induce a local change of pH (or a local change of concentration of specific species) upon illumination with a particular wavelength. Light can be currently focused at the scale of tens of femtolitre in volume, thus allowing a formidable control of the nucleation and growth of mineral phases. The applications of this new technique would be almost universal. Therefore, we plan for this project: a) to demonstrate the limits of feasibility of the methodology and patent it; b) to optimize formulations for the specific cases of carbonate and phosphate precipitation/dissolution with obvious applications in bones and teeth repair and art preservation; c) to perform a market study to have a detailed evaluation of the value of the invention while
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'How dopamine affects social and motor ability - from the human brain to the honey bee'.

assistant: **Innovation**

Parkinson’s Disease is usually characterised by motor impairment, and Autism by social difficulties. However, the co-occurrence of social and motor symptoms is critically underappreciated; Parkinson’s Disease patients exhibit social symptoms, and motor difficulties are common in Autism. At present, the biological basis of co-occurring social and motor impairment is unclear. Notably, both Autism and Parkinson’s Disease have been associated with dopamine (DA) system dysfunction and, in non-clinical populations, DA has been linked with social and motor ability. These disparate strands of research have never been combined. Brain2Bee will use psychopharmacology in typical individuals to develop a model of the relationship between DA, Motor, and Social behaviour – the DAMS model. Brain2Bee will use sophisticated genetic analysis to refine DAMS, elucidating the contributions of DA-related biological processes (e.g. synthesis, receptor expression, reuptake). Brain2Bee will then test DAMS’ predictions in patients with Parkinson’s Disease and Autism. Finally, Brain2Bee will investigate whether DAMS generalises to an animal model, the honey bee, enabling future research to unpack the cascade of biological events linking DA-related genes with social and motor behaviour.Brain2Bee will unite disparate research fields and establish the DAMS model. The causal structure of DAMS will identify the impact of dopaminergic variation on social and motor function in clinical and non-clinical populations, elucidating, for example, whether social difficulties in Parkinson’s Disease are a product of the motor difficulties caused by DA dysfunction. DAMS’ biological specificity will provide unique insight into the DA-related processes linking social and motor difficulties in Autism. Thus, Brain2Bee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Tools And Strategies to access to original bioactive compounds from Cultivation of MARine invertebrates and associated symbionts' under Horizon 2020.

assistant: **Concept**

TASCMAR project aspires to develop new tools and strategies in order to overcome existing bottlenecks in the biodiscovery and industrial exploitation of novel marine derived biomolecules (secondary metabolites and enzymes) with applications in the pharmaceuticals, nutraceuticals, cosmeceuticals and fine chemicals industries. Exploitation of neglected and underutilized marine invertebrates and symbionts from mesophotic zone will be combined with innovative approaches for the cultivation and extraction of marine organisms from lab to pilot-scale, using the unique prototypes Platotex™ and Zippertex™, both reaching the Technology Readiness Level 7. Thus, marine dedicated cultivation and extraction equipment will be built and validated. These unique improvements will ensure sustainable supply of biomass and promote the production of high added value bioactive marine compounds. An integrated, holistic technological metabolomic approach will be applied, in conjunction with bioactivity profiling, as filtering and bio-prioritisation tools. Moreover, state-of-the-art analytical instrumentation and in-house databases will be employed for the dereplication and characterization of valuable compounds. A panel of libraries (marine organisms, extracts, pure metabolites and biocatalysts) will be constructed and exploited throughout the project. A focused panel of in-vitro, cell-based, in-ovo and in-vivo bioassays for discovering metabolites with anti-ageing and/or angiogenesis modulating activity will frame the entire work-flow and will reveal the lead compounds. In addition, the catalytic potential of mesophotic symbionts and deriving enzymes candidates will be evaluated in fine chemicals and bioremediation industries. The project activities will be constantly assessed via effective ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New strategies for the treatment of cancer by targeting conformational variants of the tumor suppressor p53' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Cancer is still one of the great killers in the European Community despite significant improvements in treatment regimens. Thus, development of novel strategies for treatment ill still a major challenge for biomedical science. One of the dye problems in tackling cancer is that treatments kill both normal and cancer cells. Thus, the goal is to develop therapies that are selective for cancer cells. The gene encoding the p53 tumour suppressor is mutated in more than 50 % of all human cancers, which makes it possibly the most attractive target for cancer therapies. This study is designed to characterise differences between normal and altered forms of p53 that allow a rational design of targeted manipulation of p53 function by chemical agents or peptides. The ultimate goal of this proposal is to develop therapeutic compounds that would allow one to selectively attack tumour cells that express mutant p53 proteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable Production of High-End Wood Products Using Recycled and Environmentally Friendly Materials' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Resource efficiency is a central theme for the EC’s 2020 strategy and especially forests are among our most preciousresources. Currently, large quantities of the old wood are being recycled from buildings that are no longer needed, but therecycling yield is only 15% due to the low quality of the materials. This leads to increased prices and waiting times for highqualityfurniture and interior products which rely on solid/old wood sources.At JGrabner we have invested over €5 million in the development of our technology, creating a solution to this problem thatonly uses thin layers of the expensive old wood on top of high-quality plywood substrates, thereby increasing the recyclingyield to 60%. Our innovative process creates toxin-free, wood-based materials that not only rival the visual and hapticexperience of solid and old wood products but also surpasses them in terms of costs, customizability, durability,sustainability and availability. These quality standards cannot be reached by any of the competing technologies. WithGREEN BOARD, we will bring our technology to the interior and furniture sectors, thereby creating a new market for oldwood materials. We offer never-seen-before applications of old wood, such as floorings or wall interiors which have beenelusive till now, due to the special needs of the bulk old wood materials. With GREEN BOARD, we can customize any woodmaterial to the needs of our customers. With the customer demand for high-end wood products rising and the €361 billionfurniture and interior market growing at an average rate of 10% annually, we’re perfectly positioned to use this uniquebusiness opportunity in Europe. With a funding of €1.1 million in funding for GREEN BOARDs Phase 2, we will achieve €5.4million in profits over 3 years after the project’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Fear reduction strategies relevant for exposure therapy: Devaluation and extinction learning in anxiety disorder patients and their neurobiological basis'.

assistant: **Concept**

My ambition is to become an independent PI and clinical psychologist with a novel research line focusing on treatment optimization and personalization for anxiety disorders and post-traumatic stress disorder (PTSD). The MSCA-IF will provide the essential building blocks for this research line, and provides the opportunity to develop generic skills necessary to transfer from a postdoc position to an Assistant Professor position. Training through research: I will bring my expertise in neuroimaging and clinical psychology to the host, and the host’ PI will train me in experimental task development. The aim of ReduceFear is to examine fear reduction strategies that play a role in exposure therapy, the gold standard therapy for anxiety disorders and PTSD. These disorders are highly common, and up to 50% of patients do not benefit from the therapy. The project will concurrently assess (a) extinction learning, a process that reduces the over-expectation of harm but is highly fragile and dysfunctional in anxiety patients, and (b) threat (US) devaluation, a highly-understudied process that has potential to more robustly reduce excessive fears by reducing the perceived aversiveness of the threat. Overall objective: to examine for the first time (1) the neurobiological mechanisms of US devaluation compared to extinction learning to identify (pre)clinical targets for therapy augmentation, and (2) US devaluation mechanisms in patients with anxiety disorders. If anxiety patients not show any deficits in US devaluation, exposure-based therapies may be adapted to enhance focus on US devaluation. Hands-on training: As identified by a Gap Analysis, I will work on the following competences in order to reach scientific maturity and to successfully lead my own research group in the future:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Jacob Blaustein Institute for Desert Research (BIDR)' (BIDR).

assistant: **Concept**

Principal characteristics of the facility and of the support offered to users: The facility is a research institute in the Negev desert, with permanent 65 faculty and 60 support staff, catering for 64 visiting and temporary staff, and 100 local and foreign research students, having access to infrastructure and equipment, and option to collaborate with the permanent staff. The unique virtue of the BIDR is its multidisciplinary nature studying the drylands from all, possible aspects. This is the very reason for proposing the entire BIDR as an LSF. It offers the rare combination of an easily accessible desert environment and all the logistics and technology required for conducting modern inter-and multidisciplinary desert research. The institute thus, provides facilities in research programs: on Desert Environment (Physical and Living), Man in the Drylands, Dryland Water Research, Biological Production (Intensive and Extensive Plant Production, and Animal Production). Guests and trainees may use a solar energy test site, meteorological tower, experimental farms, remote-sensing and GIS laboratory, greenhouses and aquaculture (fish and microalgae) installations, and collaborate in photovoltaics, molecular biology, human habitat, aquaculture, bioremediation, biomass production, biodiversity and climate change studies-all under and for desert conditions. The field sites are up to 70 km off campus, covering rocky, sandy, and loessial watersheds; altitude range of -100 to 900 m above sea level; mean annual rainfall of 20 to 300 mm; hyperarid, arid and semiarid dryland types; African, Asian and Mediterranean biotes; intensive dryland agricultural farms, communities engaged in extensive agriculture and pasturalism, water resource development projects; nature reserves, ecotourism a