RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Ontology of Mental Causation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The proposal being submitted is an interdisciplinary project belonging to the area of ontology of mind. The long-term goal of the project is to find an answer to the question whether a consistent conception of events, properties and agents can be proposed and defended which would make it possible to speak about irreducible, causally potent, mental factors. Subsequent research stages of the project are: (1) The analysis of anti-dualistic arguments: the supervenience argument, the exclusion argument, the overdetermination argument; (2) The comparative and reductive analysis of causal relata; (3) The analysis of causal relation; (4) The analysis of dispositional properties; (5) The ontology of subjects of experience as rational selves and free agents. As a result of the research project, I expect: (i) preparing and developing an adequate terminology in which issues in mental causation can be framed; (ii) analysing the problem of causal relata and causal relation itself and formulating basic theses in otology of properties, events and agents; (iii) reconstructing and critically analysing anti-dualistic arguments; (iv) recognizing interconnections between various groups of metaphysical and scientific problems intertwined with such notions as overdetermination, causal closure of the physical domain, realization, determination, ontological dependence and emergence; (v) critically analysing some of the options within the mental causation debate such as anomalous monism, reductive and non-reductive physicalism and emergent dualism; (vi) developing a sufficiently rich ontology of the human person which will be in position to deliver persuasive answers to the most frequent questions that appear within the mental causation debate and the metaphysics of human being.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A light-rechargeable battery for autonomous IoT devices' (SolBat).

assistant: **Concept**

The need to power batteries in remote areas off-grid as well as the rapid development of the Internet-of-Things (IoT) sensor networks, which rely on rechargeable batteries to operate, are increasing the demand to find new solutions to couple energy harvesting systems with energy storage. In the case of the IoT platforms, charging and replacing batteries usually lead to an increased power consumption and disturbance of the data transfer. SolBat proof-of-concept aims at demonstrating a light-rechargeable battery to power a wide range of IoT sensors. The battery is miniaturized and rechargeable upon light illumination (indoor and outdoor) without an external voltage or current applied, enabling a reliable real-time continuous sensing and off-grid energy autonomy. The goal is to demonstrate powering different commercial IoT sensors by a miniaturized light-rechargeable battery and to outline a commercialization strategy for this technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transition schemes through a sustainable energy system in Sahelian countries' (1994-1998).

assistant: **Innovation**

The main objectives are defined as follows :* To determine and formulate strategically solutions for the implementation of sustainable energy systems in the Sahelian region.* To develop economical, technological, social and political policy options for the transition through the new energy system in terms of targets, implementation methods, monitoring and evaluation criteria.* To develop the local human capital through permanent involvement of the endogenous capabilities and promotion of local experts i.e. policy making abilities.* To provide follow-up to previous EU projects in this area and transfer their results into practical solutions and options.Expected OutcomeThe first major expected result of the project is to develop a comprehensive and complex set of strategical solutions for the implementation of a sustainable energy system in Sahel region. The second one is to provide a set of short, medium and long-term economical, technological, social and political policy options for the transition to new energy system. The options will be developed in terms of targets, implementation methods, and monitoring and evaluation criteria.As a result of the project implementation it could be preview the following benefits for the Sahelian countries :* Economic benefit : agricultural activities development; reducing of the imports dependency; equilibration of the external balance of payments.* Social benefits : improvement of living conditions : employment generation; reducing of uncontrolled rural - urban migration.* Environmental benefits : reducing of deforestation; reducing the pressure of uncontrolled urbanisation.The key activities are :* Development of analysis and evaluation instruments.* Research on how to improve and adapt the existing legislative, administrative and f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'A Microfabricated Actuator for Active Flow Control on Aircraft'.

assistant: **Concept**

This is a proposal for the design, manufacture and testing of an innovative prototype microfabricated pulsed flow control actuator for implementation at aircraft scale.The innovative actuator concept is one that was originally developed under previous EU RTD projects (AEROMEMS and AEROMEMSII) and demonstrated to achieve exit velocities in excess of 300 m/s at frequencies ranging between 0 and 1kHz through a 45 degree pitched orifice having a diameter of 0.4mm.This proposal extends the design of the actuator to demonstrating the required performance through a 1mm diameter orifice (as requested by CfP) and to the improvement of the fabrication processes to reduce costs and to increase production yield to levels in excess of 80%.The proposal involves demonstration of innovative manufacturing techniques to improve the accuracy of rapid grinding methods for brittle ceramics, demonstrate the use of pico- and femto-second pulsed lasers for low-damage cutting of ceramic/metallic sandwich structures and to improvement of electrical connections within the actuator.The work entails the design, fabrication and testing of the actuator and will build on significant experience and past investment. The maturity of the current actuator design concept, particularly with respect to the consideration of aircraft integration and a large range of environmental testing that has been undertaken will provide a low-risk route to realising a concept that will be close to practical implementation.During the design process advanced computational analysis tools will be used to evaluate the performance and effectiveness of the actuator and build upon the already considerable results and experience already gained.The multi-disciplinary team that will deliver this project has many years experience in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Extracellular Vesicle-Inspired CArdiac Repair'.

assistant: **Objectives**

More than 3.5 million people are newly diagnosed with heart failure every year in Europe with a long-term prognosis of 50% mortality within 4 years. There is a major need for more innovative, regenerative therapies that have the potential to change the course of disease. My hypothesis is that we can recondition heart failure by stimulating cardiac repair with extracellular vesicles that are derived from progenitor cells. In my laboratory, extracellular released vesicles containing a cocktail of stimulating factors, are amongst the most potent vectors for cardiac repair.To achieve a sustainable and long-term therapeutic effect of these vesicles and enhance cardiac function by stimulating myocardial repair, we will 1) improve local cardiac delivery of progenitor cell-derived extracellular vesicles, 2) understand the mechanism of action of extracellular vesicles, and 3) stimulate extracellular vesicles release and/or production by progenitor cells.These questions form the rationale for the current proposal in which we will co-inject extracellular vesicles and slow-release biomaterials into the damaged myocardium. By subsequent genetic tracing, we will determine fate mapping of injected vesicles in vivo, and perform further mechanistic understanding in in vitro culture models of targeted and identified myocardial cell types. Moreover, we will upscale the vesicles production by progenitor cells further via bioreactor culturing and medium-throughput screening on factors that stimulate vesicles release. The use of stem cell-derived extracellular vesicles to stimulate cardiac repair will potentially allow for an off-the shelf approach, including mechanistic understanding and future clinical use. Additionally, since these vesicles act as a natural carrier system outperforming cu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding intestinal intercellular communication using Light Induced Synchronized Protein Secretion' (GRIPP), addressing dissemination and exploitation.

assistant: **Impact**

Intercellular communication between epithelial intestinal stem cells (ISCs) and their niche Paneth cells is essential for intestinal homeostasis. It deteriorates with age promoting disease onset such as inflammation and cancer. Thus, understanding age-associated alterations in stem-niche cell communication is crucial for developing interventions to optimize tissue function in later years.To communicate, Paneth cells secrete ligands instructing proliferation and differentiation of ISCs. ISCs receive these ligands via the respective receptors on their plasma membrane. While the signaling pathways of their communication are comprehensively described, the secretory membrane transport from the inside of the cell towards the cell surface of the ligands and receptors are only poorly understood.This project will identify how ISCs and their niche cells direct the secretory transport of receptor and ligand proteins for efficient intercellular communication at the cell surface and how directed secretion functions as an intestinal homeostasis regulator. First, I will establish a novel optogenetic tool in intestinal organoids enabling spatiotemporal resolved tracing of synchronized signal secretion in ISCs and niche Paneth cells using live imaging. Second, I will reroute directed secretory transport by addition of GPI-anchors, targeted signaling motif and gene removal. In combination with transcriptomics, I will study the effects of disturbed secretion on intestinal homeostasis. Third, I will unveil alterations in directed secretory transport with age and age-related dysfunctions.The proposed project will elucidate how directed secretory transport between ISCs and their neighboring niche cells determines stem cell function for tissue homeostasis. Overall, it holds the potential to u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structure, stability, folding and function of the cancer susceptibility gene product brca 1' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Soquence analysis of BRCA1, a cancer susceptibility gene responsible for tne majority of inherited breast cancers, lead to the discovery of a conserved domain, first described in the carboxyl terminus of BRCA1, a p53 binding protein (53BP1), and the yeast DNA repair protein RAD9. The BRCI domain (for BRCAl C-terminus) revealed a large family of domains that occur predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCI domain consists of 90 100 amino acid residues and occurs as a tandem repeat at the carboxy terminal of many proteins, but has been observed also as a single copy. Determination of the three dimensional structure of the BRCT motif will be performed using nuclear magnetic resonance spectroscopy on the single BRCT domain of the telomere binding protein RAP1. In order to analyse the key residues that are important for specifying the native fold of the domain, protein engineering will be combined with stability measurements using fluorescence spectroscopy, circular dichroism and differential scanning calorimetry. A comparative study of the BRCT domain in different proteins will also be performed. The folding pathway will be characterized by fast kinetik techniques (stopped flow fluorescence). Functional studies will focus on binding studies with p53. This work should help unravel the functions of the BRCT domain and its role in the cell cycle and the evolution of cancer. Training content (objective, benefit and expected impact) The Cambridge Centre for Protdn Engineering is an Interdisciplinary Research Centre, directed by Aof A. R Fersht, FRS, which has considerable experience in the investigation of protein function, structure, stability and folding. It is therefore a privileged
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploiting the Untapped potential of Fruit tree Wild DIVersity for Sustainable Agriculture' in the context of a Horizon Europe call.

assistant: **Objectives**

Crop wild relatives (CWR) are wild plant taxa closely related to a crop. They represent an important source of genetic diversity for the improvement of agronomic traits. In the context of the One Health Initiative, temperate fruit trees are essential for human nutrition and health, yet CWR resources have hitherto been underused. Moreover, fruit tree long lifespan and a current production dominated by a few cultivars make them particularly vulnerable to the effects of global changes. To address this challenge, the FRUITDIV project will monitor, characterise, use, and conserve the diversity of emblematic fruit tree CWR, with a particular emphasis on Malus, Pyrus and Prunus.To better characterise the genetic and phenotypic diversity of CWR fruit trees and identify favourable traits for future introgression into cultivars, FRUITDIV will use a combination of floristic, ethnogeography and population genomics on genebanks and historical European hotspots of diversity. We will then develop new multiomics-based breeding strategies that combine marker-assisted introgression for traits of interest (e.g. resilience, resistance to pests and diseases, fruit quality) with pangenomic prediction and a reduction of CWR-associated genetic load.In addition to breeding programs, FRUITDIV will also work with networks of farmers and associations to help characterise CWR progeny in various pedo-climatic conditions in Europe. An European-wide online platform that provides genotyping and phenotyping data for free will be implemented to promote the use of CWR genitors by breeders and farmers and help disseminate plant material of interest for various usages and cultivation systems.Overall, the FRUITDIV multi-actor approach involving geneticists, forestry officers, germplasm curators, farmers and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Interacting Solitary Waves in Nonlinear Wave Equations' to be submitted under Horizon Europe.

assistant: **Abstract**

Various models encountered in mathematical physics possess special solutions called solitary waves, which preserve their shape astime passes. In the case of dispersive models, small perturbations of the field tend to spread, so that their amplitude decays. TheSoliton Resolution Conjecture predicts that, generically, a solution of a nonlinear dispersive partial differential equation decomposesinto a superposition of solitary waves and a perturbation of small amplitude called radiation.Our study will focus on topological solitons appearing in models motivated by Quantum Field Theory: kinks in the phi4 theory andrational maps in the O(3) sigma model. We expect that the developed techniques will have applications in the study of othertopological solitons like vortices, monopoles, Skyrmions and instantons.Our general ultimate objective goes beyond the Soliton Resolution, and consists in obtaining an asymptotic description in infinitetime, in both time directions, of solutions of the considered model. Such a description should be correct at least at main order, andreflect interesting features of the problem, which are the soliton-soliton interactions and soliton-radiation interactions.We pursue this general goal in various concrete situations, namely: the problem of unique continuation after blow-up for theequivariant wave maps equation, the collision problem for the phi4 equation, the study of pure multi-solitons in the regime of stronginteraction, and the multi-soliton uniqueness and stability problem. Their solution requires a mixture of non-perturbative and perturbativetechniques. While the former rely heavily on the concrete model, the latter will be applicable to any dispersive equation havingsolitary waves.


**Keywords:** soliton, scattering, long-time behavior
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fluid gap Electro-Active-Polymer machines for a new generation of mechatronic systems' under Horizon Europe.

assistant: **Concept**

While mechatronic solutions become increasingly pervasive, there are areas, such as the space or the ocean depths, that are still difficult to reach and exploit through conventional technologies. Yet, such areas represent an immense source of materials and energy. A bottleneck is represented by actuation/generation technologies, which struggle in unconventional environments.  Electrostatic drives based on electroactive polymers (EAPs) have long been regarded as a potentially game-changing solution, as they rely on lightweight materials and feature no rigid moving parts, but their applicability has been severely hindered by reliability and performance limitations. Recently, fluid-gap transducers (FGTs), which leverage combinations of dielectric polymers and liquids, have emerged as a breakthrough, as they have shown potential for reaching significantly improved performance and lifetime.   With this project, we will push FGTs beyond their limits, making them able to operate in low pressure atmospheres for space applications, or underwater and at high pressures for application in the marine environment. To achieve these goals, we will 1) expand base knowledge on the working principle of FGTs, 2) develop new operating principle concepts based on highly unconventional material combinations, enabled by our recent findings, such as low-pressure air/vacuum dielectric gaps, or high-permittivity mildly-conductive “leaky” dielectric liquids, 3) provide proof of concept and validation of such new paradigms in a number of relevant scenarios, including FGT-driven robotic systems able to operate in vacuum (for space applications) or underwater/at high pressure, and scaled prototypes of distributed energy harvesters from sea waves. This project will mark a leap in the field of electrom