RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Aqueous Supramolecular Polymers and Peptide Conjugates in Reversible Systems'.

assistant: **Innovation**

Supramolecular polymers are of major interest in the field of self assembly with a promising outlook in areas of viscosity modification, compartmentalized architectures, bio-conjugates and drug-delivery applications. They are dynamic macromolecular materials prepared by simple mixing of relatively small components bearing complementary or self-complementary recognition motifs. A major limitation in the field, however, has been access to synthetic systems capable of undergoing self assembly in an aqueous environment. This research proposal develops well-defined, self-organizing macromolecular structures that will overcome this limitation by focusing on systems that rely on several non-covalent interactions occurring in concert rather than on single interactions alone. The envisioned supramolecular polymers and bio-conjugates are designed as dynamic water-soluble smart materials, whose architectures can be controlled and exhibit reversibility upon exposure to external stimuli such as electrochemical, temperature or pH changes. Molecular recognition events occurring between functional handles on both synthetic and bio-polymers will be investigated in order to control the formation of desired functional architectures through stoichiometrically controlled complexation. Preparation of synthetic core motifs to assemble discrete peptide aggregates such as the dimeric through hexameric oligomers of amyloid-beta(40/42) will lead to structural elucidation and insight into several peptide misfolding pathologies like Alzheimer's or Parkinson's disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New late-stage functionalization reagents for the construction of chiral centers to impact drug discoveryhis her' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Late-stage functionalization (LSF) is a rapidly expanding field in molecular synthesis with the major goal of quickly accessing to derivatives that would be too challenging or time-consuming to prepare otherwise; hence, this strategy has a great potential to impact drug discovery processes by speeding up the hit-to-lead optimization. At present, more than two-thirds of prescription drugs contain at least one chiral center. However, the late-stage introduction of this structural motif using aromatic C–H bonds is an enduring challenge in synthesis. The goal of the NAKED-C project is to develop a new methodology for the construction of chiral centers in drug molecules, relying on the design and synthesis of a novel class of atomic carbon precursors that, upon successive and appropriate activations, would allow to build tailored asymmetric carbons. To achieve this goal, a new visible-light photoredox catalytic diazomethylation of aromatic C–H bonds will be developed. The collaboration with an industrial partner (secondment at AiCuris) will allow the application of this novel strategy to drug discovery in the search of effective antibiotics, thus merging multidisciplinary aspects with intersectoral knowledge transfer. The result will be a brand-new ‘assembly point’ for the construction of chiral centers in bioactive compounds, with the potential to become a late-stage diversity-generating synthetic platform for drug discovery programs. The proposal merges the host expertise in novel C−H functionalization strategies based on photocatalysis, and the researcher’s background in classical radical chemistry, metal-mediated synthesis and pharmacology, ensuring the two-way transfer of knowledge between the fellow and the host group. Successful development of NAKED-C will enhance the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Formal Analysis and Modeling of Human-Automation Interaction' (FMHAI), addressing dissemination and exploitation.

assistant: **Impact**

The automotive industry is transforming to embrace opportunities afforded by inexpensive yet powerful computers, sensors, and wireless technology. New vehicle designs call for implementation of sophisticated infotainment systems, mobile communication technology, and navigation systems, as well as safety features such as sensors for pedestrian detection and collision avoidance.  Next generation automobiles will employ extensive use of automation for speed and lane control, and parking assist. While continued electrification and automation of the automobile are inevitable, nevertheless, obstacles remain. Key among these is the design and development of interfaces that comfortably link drivers to largely automated, and highly connected vehicles through elegant, efficient and safe interactions. Currently there is no common, industry-wide design and specification language for describing human-computer interaction, built and packaged to integrate safety, efficiency, and driver satisfaction.  Therefore, the first objective of the proposed project is to develop such a language and syntax.  The second objective is to use formal mathematical techniques to define a generic set of “bad” properties that contribute to human error and frustration during interaction.  A third objective is to establish a set of “good” design patterns, encapsulated in a formal mathematical description, productive of consistent, efficient, and elegant human-automation interaction throughout the entire suite of automotive connectivity and automation features.  The final objective is to develop a systematic process and tools for the application of the abovementioned objectives. The project will be conducted at and in close collaboration with engineering design teams in Europe (Opel and Vauxhall).  The resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cell-free synthesis and assembly of biomolecular condensates:  Engineering properties, functions and regulation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Compartmentalization is a defining characteristic of life and has the potential to enable and improve engineered manufacturing routes in biotechnology. Many biomolecules like proteins and RNA have the ability to spontaneously cluster in molecularly dense, phase-separated liquid-like assemblies, termed biomolecular condensates. Biomolecular condensates are promising as synthetic compartments in cell-free reactions and living cells because they could provide programmable, self-assembled spatial organization and rapidly appear or dissolve on demand. However, we are still lacking key engineering and characterization tools, a fundamental understanding of how the unique material properties influence internal biochemistry, and strategies to regulate these dynamic molecular assemblies. I have recently discovered that different condensate-forming proteins can be synthesized and assemble into liquid-like droplets in cell-free transcription and translation reactions run in a custom-designed microfluidic device. This project will pioneer cell-free synthesis for the engineering and characterization of biomolecular condensates, and engineer new synthetic compartmentalization strategies for cell-free systems and living cells. First, developing and taking advantage of a highly controlled microfluidic cell-free environment we will generate and characterize new synthetic compartments with tailored properties. Secondly, we will specifically target molecules and reactions into the condensate phase and systematically study how condensate properties influence biological functions. Finally, we will implement dynamic feedback control mechanisms that can autonomously adjust presence and functions of synthetic compartments in cell-free systems and in cells. SYNSEMBL will break new grounds for ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ecological and environmental biosafety assessment of novel plant and microbial biotechnology products' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Innovative biotechnology products based on novel crops and bio inoculants offer an alternative to current agricultural practices that are damaging to the environment, and so have the potential to contribute to sustainability within theatre-food sector. Despite the benefits, public acceptance of Gomes is problematic. Consequently the objectives of this proposal are to1) assess the ecological impact of GM plants with commercially relevant traits under field conditions, and2) develop, test and assess the ecological impact of bio inoculants to replace the inputs of agric-chemicals that are deleterious to the environment. An integrated multidisciplinary Cluster Project including industrial partners will achieve these objectives. This Cluster Project will provide new scientific information to address current public concerns on Gomes and help improve the use and perception of plant and microbial biotechnology for the benefit of Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Calibration standards for surface topography measuring systems down to nanometric range' (1994-1998) under Fourth Framework.

assistant: **Objectives**

For competitiveness in the global market, the ability to manufacture goods to increasingly lower surface roughness of the functionally relevant surfaces, e.g. video recorders, microelectronic devices, machine tools, and automobile components is a simple necessity. For Quality Assurance and Process Control the precise and accurate measurement of surface topography is therefore a major technological problem in science, engineering and manufacturing industry. The problem arises due to the lack of traceable standard artefacts for instrument calibration in the X, Y and Z directions and for the calibration of filters. These problems restrict the ability quantitatively to define surface topography and create conflict between customer and manufacturer and among metrology laboratories. For the most demanding applications a whole range of recently developed and functionally related surface detection systems with resolutions down to the nanometric range are being used, none of them currently well standardised and calibrated. Therefore, for ease of trade within the EU and between the EU and the rest of the world these problems must be resolved. Existing ISO standards on calibration specimens (ISO 5436) are inadequate and extremely limited in that they only cover contacting stylus instruments and only partially the standardised measuring ranges for these instruments. The whole range of non-contacting instruments are not covered by any National or International Standards despite their widespread use in industries ranging from automotive manufacture to ultraprecision manufacture of video recorders, compact discs and data storage systems. The project is to address these problems in the following way. To devise novel traceable calibration techniques for Surface Topography Measuring Syst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sourcing methane and carbon dioxide in karst systems' (SMACKS).

assistant: **Innovation**

Climate change is inextricably linked with the carbon cycle and the natural and/or induced variations of the concentration of greenhouse gases in the atmosphere. Recent research on the microclimate dynamics and the geochemistry of subterranean karst environments suggest that these systems, for short cycles, can operate as sinks/reservoirs of carbon dioxide (CO2) during cold periods and as emitters/sources of CO2 during warmer periods. The contribution of these systems to the global fluxes of greenhouses gases could be very important but the controls on karst inputs remain poorly understood. The research proposal is aimed at identifying the environmental factors controlling the CO2 and methane (CH4) exchanges between atmosphere and subterranean environments, using innovative real-time isotope tracing to characterize the cause-effect relationships at carefully selected and well characterized cave-karst locations. Isotopic tracing of CO2  and CH4  fluxes between atmosphere, soil and caves over short period cycles (diurnal to synoptic scales, at different seasonal times) will help identify the relationships between the local environment (temperature, rainfall, atmospheric pressure etc) with the abiotic and biotic processes in the atmosphere-soil-karst system. The multidisciplinary research will characterise the major karstic process including cave microclimate, infiltration water as a transport vehicle of gases, cave ventilation using the variations of carbon isotopic signal of air, water and mineral in each phase (soil, epikarst and cave atmosphere) involved in the carbon fluxes. The results will enable a predictive model of the on longer term controls on karst associated greenhouse gases concentration into subterranean karst environments combining different micro-environm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'POsition-based ServiceS for Utilities Maintenance teams'.

assistant: **Innovation**

A correct behaviour of any utilities (Gas, water, electric networks, telecom networks and so on) requires a timely and continuous intervention of maintenance teams for resolve faults and provide network adjustments and control. Frequently the maintenance teams are equipped with positioning devices useful to locate where is required the intervention but, in many cases, the information provided are too inaccurate or worse not available due to the not visibility of GNSS satellites.The problems above mentioned have limited the application of location based services (LBS) in the utilities domain and the GNSS usage is applied mainly to the survey activities. It is possible, in any case, to envisage a wide range of advantages if the maintenance teams could use a precise, reliable, cost effective, positioning information anywhere and anytime. Our idea is strongly based on EGNOS-EDAS adoption in order to provide to the maintenance teams a terminal able to determine the position with a sub-metric precision and able to update the company GIS database when is needed. Our idea is strongly based on EGNOS-EDAS adoption in order to provide of LBS to the maintenance teams by means of a terminal able to determine the position with a sub-metric precision and a positioning infrastructure. The terminal will acts as an accurate ‘in-car navigator’ in order to indicate the best route for intervention and will able to display contextual information related to the maintenance activities (e.g. a detailed map of the utility network within the intervention area). Respect other similar solutions already available on the market (e.g. Trimble products) our solution will be able to determine the position when the satellite signals don’t are available. This goal will be achieved starting by the last acc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A multi-ingredient brain function model predicting chronic pain in youth: a window into future well-being'.

assistant: **Innovation**

Chronic pain is endemic and difficult to treat. The first surge occurs in adolescence, a critical period for brain development associated with high vulnerability. The number of adolescents with disabling pain has soared, and in most cases, pain persists into adulthood, strongly impacting long-term wellbeing. The impact of chronic pain in adolescence urgently calls for a better understanding of its causes, longitudinal predictors, and underlying biopsychosocial mechanisms. Psychosocial and physical stress in youth are critical risk factors for chronic pain in adolescence. Yet it is unknown how they interfere with individual brain physiology to predict who will develop chronic pain. I will use a longitudinal design involving adolescents undergoing major surgeries, coupled with an experimental neuroimaging approach, precision fMRI and machine learning methods to: (i) test the directionality of the association between risk factors, brain physiology and future onset of chronic pain (WP1);  (ii) identify a neurophysiological multi-ingredient model that predicts, before surgery, who will (and via what mechanisms) develop chronic postsurgical pain (WP2); and, in a subset of pre-selected patients, (iii) test whether target neurophysiological pathways track pain along subacute and chronic pain phases and after treatment (WP3). I hypothesize that target brain pathways during pain, multisensory unpleasantness and self-evaluation in an affective context will: (i) synergistically predict future onset of pain at the individual adolescent level; (ii) be associated with major risk sources, (iii) exacerbate with chronic pain and attenuate after effective treatment. The results will lay foundational tools that can be used prospectively for early identification of (patho)physiology predict
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Printable Electronics on Paper through  2D materials based inks' (PEP2D) under Horizon 2020.

assistant: **Objectives**

The vision behind the PEP2D project is to pioneer the realization of fully printed electronic circuits on flexible substrates as paper, leveraging the exceptional electronic properties of inks based on novel two- dimensional materials (2DMs), and through the wide-spread and low-cost inkjet printing technology.The development of fully printed electronic systems on flexible substrates as paper could have an unpreceded economical and societal impact on the European Union. Unleashing the potential of this technology could open new and wide applications, ranging from bio (e.g., smart patches for biometric readings), to food/medicine quality control (e.g, smart tags for checking the breaking of cold chain), or to anti-counterfeiting of valuable goods, just to cite few.Actually, technology is endeavouring to implement the main building blocks for electronic applications in the fast-growing market of flexible electronics expected to expand to 42 B€ by 2021, but available materials are missing the long-term stability and reliability, and device performance can be further improved. From this perspective, it is compulsory to develop new materials, and device architectures able to allow the fully printing of a working electronic system. PEP2D aims at designing a library of inkjet-printed electronic devices (transistors, and all linear and nonlinear components) and circuits (digital logic, memory circuits, amplifiers, transmitters, receivers) enabled by 2DMs based inks, to be eventually obtained through the use of a single tool as the inkjet process, without the need of any additional fabrications steps (i.e., use of resists, etching etc.) and in air (not in glovebox).Such a goal will be achieved by means of the synergic and complementary activities pursued within the project and ba