RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Understanding the molecular blueprint and functional complexity of the endocannabinoid metabolome in the brain'.

assistant: **Concept**

We and others have recently delineated the molecular architecture of a new feedback pathway in brain synapses, which operates as a synaptic circuit breaker. This pathway is supposed to use a group of lipid messengers as retrograde synaptic signals, the so-called endocannabinoids. Although heterogeneous in their chemical structures, these molecules along with the psychoactive compound in cannabis are thought to target the same effector in the brain, the CB1 receptor. However, the molecular catalog of these bioactive lipids and their metabolic enzymes has been expanding rapidly by recent advances in lipidomics and proteomics raising the possibility that these lipids may also serve novel, yet unidentified physiological functions. Thus, the overall aim of our research program is to define the molecular and anatomical organization of these endocannabinoid-mediated pathways and to determine their functional significance. In the present proposal, we will focus on understanding how these novel pathways regulate synaptic and extrasynaptic signaling in hippocampal neurons. Using combination of lipidomic, genetic and high-resolution anatomical approaches, we will identify distinct chemical species of endocannabinoids and will show how their metabolic enzymes are segregated into different subcellular compartments in cell type- and synapse-specific manner. Subsequently, we will use genetically encoded gain-of-function, loss-of-function and reporter constructs in imaging experiments and electrophysiological recordings to gain insights into the diverse tasks that these new pathways serve in synaptic transmission and extrasynaptic signal processing. Our proposed experiments will reveal fundamental principles of intercellular and intracellular endocannabinoid signaling in the brain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Graphene-based disruptive technologies' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework.The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology – a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth.To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Manipulating magnetic domains through femtosecond pulses of magnetic field' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

While the electronic industry has successfully entered the nanoworld following Moore’s law, the speed of manipulating and storing data lags behind, creating the so-called ultrafast technology gap. Processors already have a clock speed of a few gigahertz, while the storage on a magnetic hard disk requires a few nanoseconds. This bottleneck can also be found in magnetic random access memory devices. The use of ultrafast pulses of light has demonstrated effectiveness in manipulating magnetic orders on very short time scales. However, the physical processes involved are still poorly understood, and such a control reaches the micrometer scale at best, effectively preventing their use for high-density data storage.FemtoMagnet aims to develop an entirely new approach to manipulating magnetic domains based on the engineering of plasmonic nanodevices. For that, these devices will optically generate ultra-short, intense, and reversible pulses of magnetic field at the nanoscale, a challenge that no other technique can achieve so far. To meet its ambitious goals, my research program engineers innovative plasmonic nanostructures inversely-designed to tailor light-matter interactions at the nanoscale. Under the right illumination conditions, the electromagnetic fields generated by the nanostructure set the electrons in a metal (such as in a coil) in pseudo-continuous drift motion, in turn yielding the creation of a strong stationary magnetic field.By specifically creating and manipulating ultrafast, strong, confined and reversible pulses of magnetic field in an all-optical fashion, my research program will enable the manipulation of magnetic domains at the nanoscale and over very short timescales (a few tens of femtoseconds), opening the way to applications in ultrafast data storage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Cortical, cerebellar and spinal neuronal networks - towards an interface of computational and experimental analysis (MICROCIRCUITS)'.

assistant: **Concept**

Whereas the cell and molecular biology of the nerve cell has undergone a revolution during the last decade, we still have a fragmentary knowledge of the next level, the intrinsic function of the neuronal networks that are responsible for the basic processing and pattern generation within the brain. We will address five different networks that are experimentally amenable, and located on different levels of the CNS. They are: the columns of necrotic, hippocampal microcircuitry, cerebellar granular layer micro circuitry, network underlying locomotors activity, and spinal processing. These networks form basic processing units in the brain that underlie cognition, memory formation and the control of movement. They are chosen because; in each case there has been a rapid accumulation of information in which the partner laboratories have played a leading role. Moreover, for each type of network we combine a detailed cellular and computational approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ultra-small electrochemical aptasensors for specific dopamine real-time monitoring' (2014-2020).

assistant: **Innovation**

Nowadays, over 1.2 million people in Europe live with Parkinson’s disease (PD) considered as a complex disorder of unknown etiology, where an important number of cases are sporadic. In practice, the neurodegeneration associated with PD, also at the level of neurotransmitters (NT) misbalance, starts several years prior to the appearance of the cardinal symptoms. There are important evidences supporting that some environmental factors increase the risk of developing PD. Thus, there is the need of understanding their role and action mechanisms in order to develop therapeutic strategies and, even more important to minimize risks of PD development.The main aim of this project is to develop an ultra-small electroanalytical diagnostic platform for highly-specific real-time monitoring of NT, such as dopamine (DA). Several methods have been developed in order to address this issue, but in general they lack either specificity or high spatial/temporal resolution. In this project we propose to exploit the ability of nucleic acid aptamers to sensitively and selectively bind/catalytically transform DA and develop an ultra-small array platform for DA monitoring in small biological environments. The importance is that it will be used to measure nM/μs DA release from PC12 cells and drosophila flies, examine the molecular mechanisms of neuronal function/dysfunction, and further correlated them to particular PD risk factors.In a long-term perspective, the project aims microscopic sensors that may future be integrated with brain implants designed to restore local neuronal activity and/or NT release, such as deep brain stimulation electrodes, implanted to treat PD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'METAL CATALYZED STRATEGIES FOR C-H BOND ACTIVATION AND CYCLOADDITION. SYNTHETIC APPLICATIONS AND DISCOVERY OF NON CONVETIONAL TRANSFORMATIONS' (MCCYC), addressing dissemination and exploitation.

assistant: **Impact**

Metal catalyzed C-H bond functionalization reactions is an area of organic synthesis having an exponential development and a great acceptation in the chemist community because meets the ideals of green chemistry. In this proposal we present a project research based on the development of new strategies of C-H bond activation/cycloaddition that leads to the formation of functionalized heterocycles. Furthermore the methodology is proposed to be applied to the synthesis of piperidine acid analogs, known prenyltransferase inhibitors. The inhibition of prenyltransferases could prevent the proper functioning of the Ras (protein), which is commonly abnormally active in cancer, and it could be key for the development of new therapeutics in the fight against this widespread illness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding the complexity and architecture in protein ubiquitination' (UbiArchitect).

assistant: **Concept**

The posttranslational modification of proteins with polyubiquitin regulates virtually all aspects of cell biology. This versatility arises from eight distinct linkage types between individual ubiquitin moieties in polyubiquitin, which co-exist in cells, are independently regulated, and eventually determine the fate of the modified protein. However, ubiquitin chain architecture can be highly complex, and the extent of ‘chain branching’ is unknown. Moreover, ubiquitin also undergoes phosphorylation and acetylation, which can dramatically alter its function. A true appreciation of the complexity in the ubiquitin code can only be achieved when all above aspects are considered, and only then will it be possible to assign cellular readouts to distinct ubiquitination events and differentiate between ubiquitin signals in cells. While the complexity of ubiquitination is daunting, work from many laboratories including my own has exemplified how basic biochemistry, a detailed understanding of mechanism and quantitative mass-spectrometry allows us to study, and eventually understand, the ubiquitin code. In this proposal, new methods and approaches are outlined that will allow a detailed monitoring of polyubiquitin chain architectures from cellular samples (AIM 1), and also lead to an in depth understanding of additional posttranslational modifications, such as ubiquitin phosphorylation and acetylation in cells (AIM 2). Moreover, new research tools for unstudied K6- and K33-linked polyubiquitin will give insights into cellular roles for these linkage types (AIM 3). Our studies will focus on ubiquitination events on mitochondria leading to mitophagy, where unstudied K6-linked chains as well as phospho-ubiquitin are part of complex chain architectures, and mechanisms of signalling are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Prototype landscape assessment information system' under Fourth Framework.

assistant: **Concept**

Specific project objectives:I. Research and report upon the contribution that EO can make to the three customer groups' decision making processes;II. Develop a prototype tool to aid rapid Landscape Assessment, by creating an innovative use of EO data building upon technological advances in integrated GIS and decision support systems;III. Produce demonstration products of landscape assessment information; locational value maps based upon customised environmental criteria; related 3-D visualisation products; scenaric generation products;IV. Develop standard techniques for using EO data to identify indicators of landscape tranquility. Disseminate these to the CEO, customer segments and wider scientific community;V. Provide information and guidance to the CEO and wider scientific community on current and future opportunities and techniques using EO data for the objective assessment of landscapes.Proposal Summary:The customer groups share similar requirements within the same geographic locations, to assess the interplay of the natural and cultural landscape as it affects their particular business. By sharing landscape data across a number of customer segments, significant data cost benefits can be made, and the advantages of Earth Observation can be more widely demonstrated. This project will therefore develop a prototype system, which will allow the innovative low cost integration of EO data within the decision-making processes of these 3 customer areas. The proposed system will improve access to EO data, allow automated analysis and demonstrate a variety of EO derived information to the customer segments. PLAINS will also include an expert system to provide a context for understanding how the derived EO information might support wide ranging decision-making requirements th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on ''Multisensory Ecology': Understanding adaptive trade-offs between vision and olfaction'.

assistant: **Concept**

Sensory systems enable animals to perceive their worlds and make adaptive decisions for survival. However, finding out about the world outside is energetically expensive: it involves complex sensory systems to collect the information, and dedicated neural systems to process it. Therefore, the benefits of acquiring information need to be balanced against the costs of receiving and processing it. Consequently, evolution has equipped animals with sensory systems that fit their lifestyle and environment, to give them the information they need to enhance their survival and reproduction. However, most, if not all, animals have multiple sensory systems: how should investment in different sensory systems be balanced, and what factors affect the trade-off between investment in different sensory modalities? When environmental constraints limit the usefulness of specific sensory modalities (e.g. living in the dark), shifts in investment in different sensory modalities can occur.  What is not known is how trade-offs occur between sensory modalities that are still useful to an animal, but perhaps their relative importance changes according to lifestyle or environmental factors. This project aims to investigate the trade-off that occurs in diurnal species between the visual and olfactory systems, and explain why it occurs. I will use insects as a model system, since their neural structures, ecologies and sensory systems are well studied, and can be easily measured. I will measure the relative size of olfactory and visual systems within insect species, and test if predatory species or those that fly (i.e. species that need to rapidly assess changes in their environment) invest more in vision than olfaction. I will also test if the sizes of neural structures associated with each modali
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modern Pattern Matching' to be submitted under Horizon 2020.

assistant: **Abstract**

The advances in technology over the last decade and the massive amount of data passing through the internet has intrigued and challenged computer scientists, as the old models of computation used before this era are nowless relevant or too slow. New computational models have been suggested to tackle these technological advances. In the most basic sense, these modern models allow oneto scan the input only once, possible with small auxiliary memory. Nevertheless, modern techniques have also been introduced such as sparse recovery which has provento be a very useful tool for dealing with modern challenges, and the very popular notion of conditional lower bounds which has provided evidence of hardness for various algorithmic tasks based on very popular conjectures.Pattern matching plays a crucial role in many computing applications that can be seen in day to day life. However, its research community has only recently started gaining insight on what can be done in modern models, and is lagging behind in this respect. In particular, there are no algorithms for pattern matching problems that have utilized ideas from sparse recovery, and only recently has there been progress in proving conditional lower bounds for string problems. Furthermore, conditional lower bounds suffer from the lack of hardness conjectures which address time/space tradeoffs.This proposal will close this gap for many important pattern matching problems within the new models of computation, and will be the first to utilize modern algorithmic techniques, such as sparserecovery, and adapting them into the pattern matching world. Furthermore, this proposal will focus ondeveloping a theory for proving conditional time/space lower bounds, based on new hardness conjectures. This will greatly influence not only th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigating the impact of dysregulated inflammation in interferonopathy on hematopoiesis' in the context of a Horizon Europe call.

assistant: **Objectives**

Hematopoietic stem cells (HSCs), mostly quiescent cells in the bone marrow (BM), are essential throughout life because they are responsible for the continuous production of blood cells. They are of major clinical significance in the context of transplantation for hematological malignancy and the treatment of genetic hematological diseases. Despite major advances in our understanding of the biology of the blood system, understanding the progression of normal versus malignant hematopoiesis, clonal hematopoiesis (CH) or immune disorders is still challenging.My proposal is based on the finding that unbalanced tonic interferon signaling (TIS) emanating from the microbiome in vivo, accelerates the progression of myeloproliferative diseases induced by mutation of the hematopoietic tumor suppressor Tet2. Moreover, another component of TIS, called basal TIS is a fundamental mechanism underlying physiological HSC aging. In this proposal,  I would like to explore the role of dysregulated inflammation, as in the case of interferonopathies, on hematopoiesis and hematopoietic stem and progenitor cell (HSPC) biology. I will use advanced molecular tools and technologies and a novel zebrafish model developed within this porposal. I hypothesize that understanding the interplay between chronic IFN activation on the HSCs and progeny over time could be crucial for developing effective treatments and improving outcomes for patients with these challenging disorders.This project will provide incisive insight into the biology of stem cells and into the role of inflammation on hematological malignancies.


**Keywords:** Innate Immunity and inflammation; hematopoietic stem cell; hematopoiesis; type I interferon