RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Science in the City'.

assistant: **Objectives**

Science in the City (SitC) is a nationwide festival that marries science to art to showcase Maltese researchers and their work. We place researchers on centre stage at every single activity to show the public how researchers’ work positively affects society and our daily lives. It will help change current stereotype around scientists and promote gender balance. Each activity is created around the values that science is fun, interesting, inclusive and can provide an extremely rewarding career.The activities will fill Valletta, Malta’s Capital City, with the wonders of science in a highly fascinating, innovative and interactive way. The University of Malta will lead a unique and efficient consortium of beneficiaries and partners to make ERN 2014 and 2015 two entertaining and memorable events. Through a comprehensive awareness campaign we will reach over 300,000 people to attract 20,000 (c. 5%) people in 2014 and 25,000 (c. 6%) people in 2015.As a UNESCO world heritage site, Valletta is a magnificent backdrop. Over 35 activities will run in the streets and buildings from City Gate to the heart of Valletta, Pjazza San Gorg and the Magisterial Palace of the Knights of Malta. From ancient gardens to restored squares, the public can easily visit all activities on foot.SitC will emphasise the relevance of science and research to everyday life, attuned to Maltese culture. Arts and cultural activities will be performed to communicate science. Researchers will be present in all activities. Over 80 researchers (~16% of total researchers in Malta) are involved in SitC.The schedule is highly dynamic having a general appeal. To encourage science career uptake, activities include hands on experiments, art installations, science activities, bird tracking and games aimed at very young ki
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The origins of thermonuclear supernova explosions' under Horizon 2020.

assistant: **Concept**

Type-Ia supernovae (SNe) are thought to originate from thermonuclear explosions of carbon-oxygen (CO) white-dwarfs (WDs). They play a key role in the evolution of the universe (producing most of the Iron-peak elements); and serve as critical cosmological distance-indicators. The main proposed SNe progenitors are CO-WDs accreting material from stellar companions; and mergers of two CO-WDs. However, all suggested models fail to reproduce the diverse physical characteristics of Ia-SNe; their inferred rates/ages/luminosity distrbution; and their puzzling wide sub-types diversity. Finding the origins and the evolutionary pathways of thermonuclear SNe remains one of the most important “holy grail” open questions in modern astronomy. Here we propose novel directions and potential solutions to this question, and suggest new scenarios for the origin of all sub-types of thermonucelar SNe. Supported by preliminary results, we propose that (1) the little-explored mergers of CO-WDs with hybrid He-CO WDs play a key-role in producing most types of SNe, and may provide a viable model for the origin of the majority of thermonuclear SNe, their diversity and their distrbutions; (2) neutron star-WD mergers may explain the origin of peculiar rapidly evolving SNe; (3) the channel of exploding accretion-grown massive CO-WDs never/rarely gives rise to standard Ia-SNe. We propose an end-to-end open-source-based modelling of SNe (providing easy access and reproducibiliy of our results) including stellar evolution of their progenitors; 3D hydro simulations of WD mergers; 2D (+3D) thermonuclear-hydrodynamical+radiative-transfer models (predicting detailed light-curve/spectra/compostion observables); and population synthesis studies. Our proposed science can potentially transform the field; solve t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Harmonization of Regulation of Abusive Non-Judicial Debt Collection in the European Union: Models, Benefits and Challenges'.

assistant: **Objectives**

Non-judicial debt-collection (NJDC) designates all methods employed by a creditor for debt recovery that do not involve the judiciary or other state agents (bailiffs, sheriffs, or police officers). In other words, it is a form of private enforcement. It is a phenomenon acknowledged by various legal documents (the Draft Common Frame of Reference, the Fair Debt Collection Practices Act in the USA or the Consumer Credit Sourcebook in the UK). NJDC methods are rampant in practice today in all EU legal systems, yet they are regulated only by few of them.      Due to the absence of due process and other procedural guarantees generally offered by judicial enforcement, NJDC is sometimes abusive in nature. Abusive NJDC refers to debt collection practices infringing the consumer- and commercial debtor (in particular small medium enterprises)'s rights to privacy, dignity, safety and health as well as economic and other legal rights.     The overall aim of ECHO is to fill in a serious gap in legal knowledge regarding NJDC and contribute to the improvement of the legal base and regulation of these practices across Europe. Through a close and fine-grained comparative analysis, ECHO will first assess the role and appropriateness of current EU legislation in tackling the issue of abusive NJDC. Secondly, it will analyze sectoral national legislation of EU member states (where it exists) and identify policy aims, similarities and differences of various models concerning regulation of abusive NJDC, in order to identify (or propose) the most suitable ones. Thirdly, it will assess the role of traditional liability remedies – civil, administrative, or criminal enforcement, level of fines and damages – in solving the issue of abusive NJDC across the EU. Finally, it will explore models to iden
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'PISCOPIA Programme'.

assistant: **Innovation**

The “PISCOPIA Programme” is a new programme promoted by the University of Padova and aims at increasing the European-wide mobility possibilities for multisectoral training and career development of experienced researchers, in line with the objectives set out in the “Life-long training and career development” of the People work program.Increasing the amount of incoming young researchers in the University of Padova will provide benefits to the whole Italian and European Research Areas by opening a large and high quality area to trans-national research mobility. The programme will further help to reintegrate researchers into a research career in the Member States and Associated Countries.The programme will last 60 months and provides for 3 calls, awarding fellowships lasting from 12 to 24 months and included into 2 mobility schemes:- 2 incoming calls: applicants from any country inside or outside Europe (35 fellow-years).- 1 re-integration call: applicants from Member State or Associated Countries interested in returning to Europe after a mobility experience in a Third Country (10 fellow-years).All the disciplines present at the University will be open for fellowships. Three Scientific macro areas group the disciplines studied at UNIPD and cover the entire spectrum of science and scholarship: Physical Sciences and Engineering, Life Sciences, Social sciences and Humanities.In compliance with the European Charter of Researchers and the Code of Conduct for the Recruitment of Researchers, the University of Padova will ensure that the fellows will be selected following an open, transparent, impartial and equitable selection process and will enter a research contract with the selected fellows which has all the features of an employment contract.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Enzyme-Mediated Dynamic Combinatorial Chemistry'.

assistant: **Innovation**

Biomolecular templates define the outcomes of enzymatic reactions in some of the most fundamental of biological processes, such as DNA replication, transcription and translation. In synthetic chemistry, molecular templates have enabled the synthesis of highly complex molecular architectures and interlocked structures. The possibility to use synthetic templates to direct enzymatic reactions and obtain alternative products to those generated in Nature will be investigated in this project.  The overall objective of this research programme is to explore a conceptually new approach to the use of enzymes for chemical synthesis and thus establish a new synthetic methodology - Template-Directed Enzyme-Mediated Dynamic Combinatorial Chemistry. We will exploit the inherent reversibility of enzymatic reactions to generate dynamic chemical networks, which can be manipulated via supramolecular interactions with artificial template molecules to promote the preferential synthesis of specific products. To implement this novel concept, we will develop an unprecedented, templated, enzymatic approach to oligosaccharide synthesis. We will explore dynamic systems of interconverting glycans with the goal of accessing unusual or challenging oligosaccharide products.  The specific aims are:  1. To achieve templated enzymatic selective synthesis of large-ring cyclodextrins (cyclodextrins (CDs) with more than 8 glucose units).  2. To explore cyclodextrin glucanotransferase-mediated dynamic mixtures of modified CDs, and, using thiol-functionalised CDs, develop a doubly dynamic system that combines reversible transglycosylation with disulfide exchange.  3. To generate phosphorylase-mediated dynamic mixtures of linear α-1,4-glycans and employ templates to achieve length- and sequence-selective synt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Setting up the spindle in the mammalian egg for meiosis and embryo development' (ACENTSPINTUB), addressing dissemination and exploitation.

assistant: **Impact**

An increase in the age of onset of child-bearing increases in developed countries is leading to an increased incidence of chromosome abnormalities arising in defective meiosis. Accurate chromosome segregation requires a correctly assembled meiotic spindle and so it is essential to understand this process. Here we propose to examine how the spindle forms in the oocytes and early embryos of the mouse that, like human oocytes, lack centrioles.  Nevertheless, spindle formation in these cells requires the function of Polo-like kinase 4, a protein that in somatic cells regulates centriole duplication. Plk4 localises to the acentriolar microtubule organising centres (MTOCs) where it particptates in regulating the nucleation of microtubules. We now wish to determine how Plk4 functions in these acentriolar cells to participate in spindle formation. This requires identifying the molecular partners of Plk4; the mechanisms that regulate its sub-cellular localisation to be in the vicinity of its substrates; and to identify its molecular substrates. We will also determine how it interacts with the Ran-GTP pathway, the other major pathway that regulates spindle formation in the absence of centrosomes. In the second part of the proposal we will address the behaviour of MTOCs in the oocyte and early embryo. There appear to be two distinct populations of MTOCs in the oocyte, one of which, the cytoplasmic MTOCs, appear to be essential for spindle bipolarity during metaphase by anchoring polar MTOCs. We wish to characterise these MTOCs to determine how they might differ from those at the spindle poles. The acentriolar MTOCs can also show differential behaviour at the spindle poles. This is most evident in the asymmetrical fate determining divisions at the 8-16 and 16-32 cell stage of the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'TRAPEZE - TRAnsparency, Privacy and security for European citiZEns'.

assistant: **Objectives**

The TRAPEZE project aims to drive a cultural shift in the protection of the European data economy by weaving trust into its very foundation and reconstructing the concepts of control, transparency, and compliance through technical and methodological, citizen-first, innovations. Driven by the needs of three distinct real-world use cases, TRAPEZE brings together over a decade worth of EU-funded research in security and privacy, as well as proprietary solutions and know-how, towards realistic and marketable solutions. We will develop technologies which: (i) empower citizens with the necessary tools and know-how to manage their security and privacy and actively contribute to the cyber resilience of the common European data space; (ii) enforce the integrity and nonrepudiation of citizens’ data usage policies and processing across data sources and controllers’ borders; (iii) dynamically acquire citizens’ consent and adjust their data policies in real time in response to their changing circumstances; (iv) protect citizens’ online communications and applications running on their personal devices against malicious agents; and (v) provide citizens, as well as other relevant stakeholders (including controllers, CERTs/CSIRTs, and data protection authorities) with a comprehensible overview of transborder data lineage and flows, as well as proof of legal compliance, even in big data environments. By relying on Linked Data and Blockchain, TRAPEZE will lead the way in putting the often-misplaced cutting-edge technologies to practical use and become a lighthouse for European and global initiatives aiming to deliver privacy-aware innovations. Finally, to ensure citizens of all groups can have an active role in the protection of their data flows, TRAPEZE will place a special emphasis on u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Axon Initial Segment plasticity: unravelling the mechanisms that control neuronal excitability' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Neurons have the remarkable ability to continuously integrate and propagate information while maintaining their activity state within physiological range. The axon initial segment (AIS) is the keystone of neuronal excitability and pivotal for the maintenance of network homeostasis. The molecular organization of the AIS dictates the generation of action potentials, and thereby shapes the principal output of neurons. Although the AIS has long been considered as a static and passive structure, recent work from my lab and others demonstrated that network activity induces robust plasticity of the AIS, causing long-lasting changes in excitability. However, how AIS plasticity is regulated to maintain network homeostasis remains elusive.In this proposal, I aim to resolve, at the molecular level, how the AIS adapts in response to acute and chronic changes in neuronal activity and how maladaptation may lead to disease. To this end, I developed genome editing tools to label and manipulate endogenous AIS components, enabling live and super-resolution imaging of AIS organization. In combination with proteomics, optogenetics and electrophysiology, this project will address the following key objectives:1. Resolve the nanoscale distribution and dynamics of AIS components 2. Unravel the mechanisms controlling acute and chronic re-distribution of ion channels during AIS plasticity and their consequences for excitability3. Address the implication of maladaptive AIS plasticity in the pathology of Angelman SyndromeThis project bridges the cell biology of the neuron to its physiology, provides new insights into how AIS plasticity orchestrates network activity and identifies how maladaptation contributes to disease.


**Keywords:** axon initial segment, neuronal cell biology, neuronal plastic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Induced microseismics applications from global earthquake studies' to be submitted under Sixth Framework.

assistant: **Abstract**

This TOK Industry-Academia Partnership Scheme project proposes a two-way transfer of knowledge between petroleum industry and global earthquake seismology.The project will benefit petroleum industry by developing tools and techniques for seismic monitoring of gas and oil reservoirs (hydraulic fracture monitoring and passive seismic) to control rock fracturing, optimize the reservoir production, prolong life of existing reservoirs, and mitigate hazard associated with the occurrence of induced microearthquakes. The seismic monitoring will substantially help to solve geomechanical problems in petroleum industry, such as imaging deformations associated with primary production, secondary recovery or waste injection operations.Earthquake seismology will benefit from the project by having an access to high-quality data of seismicity in reservoirs and a unique opportunity:- to study fluid-driven seismicity, in particular, rock-fluid interactions and the role of pore-fluid pressure in seismicity pattern and in triggering of earthquakes by fluid flow, and- to inspect rupture processes in a field scale and under controlled conditions.The project promotes synergy between some of the best academic institutions in the newly joining EU Member State (Charles University and Academy of Sciences in the Czech Republic) with one of a top industry-oriented private research centre in the West Europe (Schlumberger Cambridge Research), having thus a capacity to produce excellent results reputable in the world.The project promotes a collaboration of EU academic and industrial partners with a top U.S.A. expert in hydraulic fracture monitoring J. Rutledge from the Los Alamos National Laboratory, who will be an external advisor of the project. The project will be supervised by the rock mechanics gu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Harnessing the potential of mRNA vaccination as a therapeutic strategy for asthma' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Dendritic cells (DCs) are antigen presenting cells that promote immunity to pathogens, as well as tolerance to innocuous antigens, and are therefore critical regulators of both immunity and immune homeostasis. However, during asthma this ability to promote peripheral tolerance is dysregulated, leading to the formation of inappropriate TH2 responses to harmless antigens, and allergic inflammation in the airway. Peripheral tolerance has been postulated to be promoted by DCs undergoing homeostatic maturation, a process by which DCs become activated, migrate, and gain the ability to present antigen in the absence of inflammatory stimuli.Recent data from my host laboratory has shown that DCs exposed to unadjuvanted lipid nanoparticles (LNP) undergo homeostatic maturation, mimicking the response DCs mount to apoptotic bodies. In addition, unadjuvanted LNPs containing peptide cargo lead to reduced T cell responses mounted to these specific peptides, suggesting that LNPs can promote peripheral tolerance. LNP vaccines containing purified mRNA free of dsRNA contaminants also can be rendered non-immunogenic. mRNAsthma aims to adapt this phenomenon to the lung tissue microenvironment, by which DC and T cell responses to mRNA vaccines will be characterised at steady-state and during airway inflammation. In a subsequent step, we will assess if we can exploit this approach to protect from HDM-induced asthma. mRNAsthma also has an ambitious CITEseq experiment, to generate mechanistic insight of the interactions between cDC and T cells in the lung. mRNAsthma represents an important step in my research career, to increase my skillset and learn from leaders in my field. I will use this project to advance my skills in bioinformatic analysis, as well as my skills in leadership, mentorship a