RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A systems and targeted approach to alternative splicing in the developing and diseased heart: Translating basic cell biology to improved cardiac function' to be submitted under Seventh Framework.

assistant: **Abstract**

Cardiovascular disease keeps the top spot in mortality statistics in Europe with 2 million deaths annually and although prevention and therapy have continuously been improved, the prevalence of heart failure continues to rise. While contractile (systolic) dysfunction is readily accessible to pharmacological treatment, there is a lack of therapeutic options for reduced ventricular filling (diastolic dysfunction). The diastolic properties of the heart are largely determined by the giant sarcomeric protein titin, which is alternatively spliced to adjust the elastic properties of the cardiomyocyte. We have recently identified a titin splice factor that plays a parallel role in cardiac disease and postnatal development. It targets a subset of genes that concertedly affect biomechanics, electrical activity, and signal transduction and suggests alternative splicing as a novel therapeutic target in heart disease. Here we will build on the titin splice factor to identify regulatory principles and cofactors that adjust cardiac isoform expression. In a complementary approach we will investigate titin mRNA binding proteins to provide a comprehensive analysis of factors governing titin’s differential splicing in cardiac development, health, and disease. Based on its distinctive role in ventricular filling we will evaluate titin splicing as a therapeutic target in diastolic heart failure and use a titin based reporter assay to identify small molecules to interfere with titin isoform expression. Finally, we will evaluate the effects of altered alternative splicing on diastolic dysfunction in vivo utilizing the splice deficient mutant and our available animal models for diastolic dysfunction.The overall scientific goal of the proposed work is to investigate the regulation of cardiac al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Innovative, minimally invasive device to support the natural movement of the heart in heart failure patients' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Syntach CS is a groundbreaking, life-saving device for long-term cardiac support that restores the natural function of the heart’s mitral plane movement in patients suffering from left ventricular heart failure. The technology is based on recent findings of the physiological movement of        the intact heart, which pumps with a scooping, longitudinal movement of the mitral valve. In heart failure, this movement is impaired and the heart is unable to pump enough blood to meet the metabolic needs of the body. Syntach CS works in synchronization with the heart, supports the cardiac        movements and reestablishes a natural, healthy movement. It is fully implantable in a minimally invasive procedure. Heart movement support is enabled thanks to a mitral anchor ring connected to a drive unit implanted in the lower apex region of the heart from which a pulsatile movement is        transferred to the mitral plane. The system is recharged and monitored wirelessly with no elements protruding through the skin.


**Keywords:** New treatment method,Heart failure,Active implantable medical device,Medical devices,Cardiac support,Cardiac systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'INNOVATIVE THERMAL MANAGEMENT CONCEPTS FOR THERMAL PROTECTION OF FUTURE SPACE VEHICLES'.

assistant: **Innovation**

There are key space technologies existing at European level and during the last space calls many European projects are framed on space re-entry, but none of them dealing with radically new technologies, able to compete with technologies from other leading countries or allowing collaboration with them. The THOR project will provide knowledge in key space technologies for accessing space, through the design and development of disruptive technologies based on novel thermal management concepts which are specifically targeted to atmospheric entries of future space vehicles and hypersonic transport vehicles. This project, including the participation of several SMEs and relevant end-users, aims at the collaboration among them to strengthen the European space sector and enable international cooperation.The technical approach is focused non-local concepts for thermal management including active cooling as well as passive cooling technologies, in order to extent the capabilities of re-usable Thermal Protection Systems (TPS) towards the requirement of future space flight including hypersonic transport. To achieve this technical target radically new thermal management solutions will be implemented in a new concept of TPS together with innovative materials and unique ceramic structures, reaching a TRL 2-3 at the end of the project. The passive systems will be based on thermal equilibration establishing an efficient heat transfer from highly loaded areas to regions with less loading. New ceramic matrix composites incorporating a new generation of highly thermal conductive fibres will be applied. In addition, active cooling will be implemented by passing a fluid through a ceramic porous structure. The project includes a strong effort on design, modelling and simulation in order to ful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Neuron Type Atlas of the Annelid Brain: Development and Evolution of Chemosensory-Motor Circuits' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Neural circuits, composed of interconnected neurons, represent the basic unit of the nervous system. One way to understand the highly complex arrangement of cross-talking, serial and parallel circuits is to resolve its developmental and evolutionary emergence. The rationale of the research proposal presented here is to elucidate the complex circuitry of the vertebrate and insect forebrain by comparison to the much simpler and evolutionary ancient “connectome” of the marine annelid Platynereis dumerilii. We will build a unique resource, the Platynereis Neuron Type Atlas, combining, for the first time, neuronal morphologies, axonal projections, cellular expression profiling and developmental lineage for an entire bilaterian brain. We will focus on five days old larvae when most adult neuron types are already present in small number and large part of the axonal scaffold in place.Building on the Neuron Type Atlas, the second part of the proposal envisages the functional dissection of the Platynereis chemosensory-motor forebrain circuits. A newly developed microfluidics behavioural assay system, together with a cell-based GPCR screening will identify partaking neurons. Zinc finger nuclease-mediated knockout of circuit-specific transcription factors as identified from the Atlas will reveal circuit-specific gene regulatory networks, downstream effector genes and functional characteristics. Laser ablation of GFP-labeled single neurons and axonal connections will yield further insight into the function of circuit components and subcircuits. Given the ancient nature of the Platynereis brain, this research is expected to reveal a simple, developmental and evolutionary “blueprint” for the olfactory circuits in mice and flies and to shed new light on the evolution of information pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Complexity: Agents, Volatility, Evidence and Scale' under Sixth Framework.

assistant: **Concept**

The purpose of the CAVES project is to couple policy concerns for complex human-environmental systems with linked physical, biological and social models based soundly in complexity science. We will produce a constructive demonstration of modelling proced ures for the formation of social policy in conditions of uncertainty due to complexity. To do so, we will develop a set of case studies of land use change driven by a variety of physical, biological and sociopolitical phenomena. These case studies will p rovide extensive qualitative and quantitative evidence that will constrain clusters of agent based models to be implemented for each case study. The models in each of these clusters will include rich cognitive specifications of agents representing differe nt stakeholders and models with more agents but simpler representations of cognition. Some models will aggregate stakeholder groups. Others will abstract from the detail of the case studies in order to provide simpler models that may yield some closed fo rm solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Foraging activity and orientating behaviour of Antarctic fur seal at Kerguelen Archipelago in relation to oceanographic conditions'.

assistant: **Objectives**

Research objectives and content Since the importance of marine animals as bio-indicators for studies aimed at assessing the condition of the environment and for habitat protection is well known, the aim of this postdoctoral research project, is to investigate by telemetry techniques, such as satellite tracking and data-loggers, 1) how a piniped species, the Antarctic fur seal (Arctocephalus gazella) search their environment for prey and may modify their route in relation to environmental clues, and 2) how major scale changes in environment conditions may affect the at sea behaviour, and thus the foraging success and the demography of the population. Training content (objective, benefit and expected impact) - complete my training: - in animal orientation process in relation to environmental factors, - foraging ecology of marine predators, - on bio-monitoring of marine environment by using marine predators, - improvement of my skills in using new telemetry device and in data processing. - the training provided by this post doctoral will improve my chances of finding a research-teaching position within the university. Links with industry / industrial relevance (22) The industrial relevance is the improvement of a data-logger developed by National Council of Research of Pisa and creation of new software that should lead to useful device in animal field studies built by an European industry and commercialised as other devices used in animal studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Secretariat of Global research collaboration for infectious disease preparedness' to be submitted under Horizon Europe.

assistant: **Abstract**

GloPID-R-Sec III is the Secretariat to the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R).Charité Universitätsmedizin Berlin (CHARITÉ) has decided to fulfil the role of Coordinator of the Secretariat, in close consultation with Fondation Mérieux (FMER; previous Secretariat coordinator), and the University of Oxford (UOXF; continuing key technical partner).As GloPID-R is continuously evolving its organization and structure, so must the Secretariat evolve. GloPID-R Sec III provides the opportunity to move towards a collaborative leadership model, aligned with GloPID-R’s vision, aiming to respond to the increased willingness from funders to work together, and to the increased work scope for GloPID-R and the Secretariat due to the lessons learned from the COVID-19 pandemic.The objectives and core activities of GloPID-R Sec III encompass:-Core organisational and secretarial services: To provide operational secretarial, organisational, and administrative support to the GloPID-R organisation;-Communication and stakeholder engagement support-oriented services: To implement, maintain and evaluate an effective external communications and advocacy programme to support communications with GloPID-R Members and stakeholders;-Technical support-oriented services: To support the further development and operationalisation of GloPID-R’s strategy by providing expert technical and operational support to its Executive Board and Working Groups.Critically, to meet the expectations of GloPID-R, the Secretariat must continuously explore and implement key adaptations that improve the effective coordination between (inter)national funders and stakeholders for a rapid research response to public health emergencies. Thus, our work plan has been devised to adjust to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploitation of Chinese biodiversity resources in sustainalble crop production, using a biotechnological approach for rhizobial diversity evaluation, strain improvement and risk assessment' in the context of a Fourth Framework call.

assistant: **Objectives**

* To characterize Chinese rhizobial biodiversity resources.* To develop especially the molecular methods used for bacterial classification and identification.* To look for specific genes involved in stress tolerance in order to facilitate their cloning and transfer in the future.* To match plant and rhizobial genotypes by finding molecular markers indicative of compatibility for high-yielding, efficient nitrogen-fixing symbioses.* To perform inoculation trials with selected plants, rhizobial strains and other plant-growth promoting bacteria in several different regions and conditions and to measure inoculation success, and effect on soil quality, and monitor the spread of wild-type organisms.* To improve inoculant quality, production and use.Expected OutcomeChina as a region offers one of the widest spectra of rhizobial biodiversity in the world. This natural resource is still underexplored and underexploited for sustainable production in agriculture and forestry. When sampled and characterized, rhizobia adapted to diverse climates, to native and introduced crops and to legumes with future potential in revegetation of degraded land and in afforestation can be utilized in agriculture. Results from controlled inoculation trials in several different regions are used to evaluate the potential of the strain and the best strains are used in inoculant preparations. Increased sustainability and optimized input efficiency by reduced fertilizer nitrogen losses, improved stress tolerance of legumes, more stable production through high-quality inoculation, better soil fertility and prevention of land degradation will be reached by using novel biotechnological approaches.During the first year:1) Root nodule bacteria (rhizobia) that nodulate the introduced peanut plant (Arachis hypog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Privatization, Partnership and Public Service Delivery' under Sixth Framework.

assistant: **Concept**

In the last twenty years there has been a major international wave of privatisation, which has shifted many public sector activities into the private sector. The majority of these cases follow a `traditional¿ model where the government privatises and then establishes an ¿arms length¿ relationship with the privatized provider. This, however, is only one model of privatisation. There are many circumstances where it is inappropriate and in more recent `privatisations¿ there is a growing emphasis on different models, e.g., Public-Private Partnerships (PPPs), in a range of sectors, notably for public services such as health, education, and infrastructure provision. These `less-than-arms-length¿ privatisations and partnerships are now becoming of enormous signifi cance in the EU and the rest of the word, both in terms of the focus of public policy and their aggregate economic scale. However these newer privatisation models, and the relationships between government and privatised companies in `conventional¿ privati sation models, has received far less attention from researchers. The main objective of this series of conferences is to understand the interrelationship between government and private sector in privatisations and partnerships. In particular, the object ive is to contribute to:-An analytical understanding of the complex relationships between government and private provider -An assessment and interrogation of the appropriate experience of developing countries and transition countries -An understanding of t he aptness of the various delivery models (arms length, partnership, not-for-profit) at the public-private interface-when particular approaches work, when they may fail and why; -An understanding of the impact of privatisation (and different modes of priva tisation)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Safety critical embedded systems: from requirements to system architecture' (SACRES) targeting Fourth Framework.

assistant: **Abstract**

Three major software-related trends dominate most technological industries today: The costs for software development are exploding and already dominate the development costs, the features that determine purchase decisions are implemented in software, and the demand for complex safety-critical systems is rapidly increasing. Academic advances in the specification, verification and code generation of such systems have provided new technologies which can be used to improve dramatically the conventional way of building them. While commercial tools are already available, which successfully apply such techniques to the design of system components or smaller systems, it is generally recognised that the design of complex safety-critical systems requires a multi-formalism approach which combines visual programming as an engineer-friendly means of capturing and validating user requirements and formal methods for guaranteeing high quality specifications as well as provably correct generated code.The objective of providing an integrated set of formalisms and supporting methods and tools brings together in SACRES industrial developers of safety critical systems, tool vendors and technology providers. The industrial users (British Aerospace, Siemens and SNECMA) will provide design tasks, help develop supporting design methodologies and generally assess the new approach in the context of real applications. The vendors (i-Logix, SNI and TNI) adapt and enhance their products in accordance with the needs of the users. The technology providers (INRIA, OFFIS, Siemens, and Weizmann Institute) will close the remaining technology gaps.Since non-functional requirements such as real-time properties and distributed architectures are strongly requested by users, the project will develop new techno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Radiative corrections for lep2 physics'.

assistant: **Concept**

Our proposal consists of calculating and analysing the radiative corrections to processes relevant for LEP2 physics, and especially W pair production. We propose to parametrize these corrections in a manifestly gauge independent way in terms of the pinch technique (PT) self- energy, vertex, and box functions and subsequently tabulate them for use in automated codes. Specifically the objective is to: - Avoid numerically, large gauge cancellations. - Examine the size of individual contributions of different classes of one-loop graphs to the total cross-section - Extract important physical quantities, such as running couplings and form factors from the LEP data. - Define the improved Born approximation for complicated processes involving three or more particles in the final state and obtain higher-order estimates for them. - Construct automated codes for the calculation of one-loop cross-sections. - Investigate the off-shell W pair production at the one-loop level.