RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Dissection of novel protein kinase cascades that are triggered by insulin'.

assistant: **Objectives**

The main aim of this project is to elucidate the molecular mechanism by which insulin regulates the synthesis of glycogen and other biosynthetic processes in mammalian skeletal muscle. It is well known that defects in the regulation of glycogen synthase (GS) by insulin contribute to the insulin resistence observed in NIDDM patiens, obesity, hypertension and IDDM. The activation of GS by insulin is achieved through the inhibition of GS Kinase 3 (GSK3). Recents evidences showed that this inhibition is caused in vivo by its phosphorylation by the protein kinase c-Akt. In its turn, c-Akt is activated by phosphorylation in response to insulin. Recent experiments in the MRC Protein phosphorylation Unit have identified a novel insulin-stimulated protein kinase which phosphorylates a synthetic peptide corresponding to one region of the c-Akt protein. The objective of the project is to characterise the protein kinase(s) and phosphatase(s) responsible for the catalysis of the phospho-dephosphorilation of c-Akt and to discover how it is activated by insulin. The elucidation of this important insulin signal transduction pathway may contribute to the development of treatments of diabetes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolution of the social brain: How social complexity affects individual cognition in ants' (BrainiAnts).

assistant: **Concept**

This project aims to answer a significant open question in evolutionary neurobiology: how social complexity shapes the brain structure, its associated metabolic costs, and the behavioural capability of individual members of a society. The Social Brain Hypothesis proposes that the complexity of living in group influences encephalization in vertebrates, but this theory has not been critically tested in invertebrate species. Social insects such as ants have miniaturized brains that nevertheless support highly coordinated collective behaviour and striking individual cognitive abilities. This collective behaviour produces an “externalized” distributed processing of information that may reduce energetic expenses in individual brains.  We propose to address this question through the study of brain metabolic costs of ant foragers under different conditions of sociality. We will examine the effect of distributed information processing (such as the use of pheromones trails to coordinate group activity) on individual cognitive abilities (such as learning) and the energetic costs of specialized brain compartments that underlie behaviour. Our interdisciplinary methodology will combine techniques applied to the study of collective animal behaviour (individual tracking in collective choice and foraging experiments) and neurobiology (immunohistochemistry and neuroanatomical scaling, cytochrome oxidase staining and learning assays) in sister clades of ants that show strong differences in social complexity and thus the relative roles of individual workers and cooperative groups. This novel and integrated approach will allow us to analyze the evolutionary relationship between social complexity and brain evolution.


**Keywords:** Collective behaviour, Social insects, Ants, Foraging, Phero
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gene x environment interactions in affective disorders - elucidating molecular mechanisms' under Seventh Framework.

assistant: **Concept**

Exposure to traumatic experiences as well as chronic stress has been shown to increase the risk for a number of psychiatric disorders including major depression and anxiety disorders by inducing longterm alterations in the reactivity of the stress hormone system. These effects can be moderated by genetic variants, one of them being functional polymorphisms in glucocorticoid receptor (GR) co-chaperone gene FKBP5. Preliminary studies in my laboratory suggest that this GxE interaction is mediated by allele-specific de-methylation of intronic glucocorticoid response elements (GREs) within FKBP5. The overarching aim of this grant is to identify the molecular mechanisms by which FKBP5 polymorphisms and early trauma interact to increase the risk for a number of depressive and anxiety disorders. In this application, I propose to extend these preliminary data by experiments in healthy controls and depressed patients, human lymphoblastiod cell lines as well as an animal model in outbred mice showing similar GxE interaction to address the molecular mechanism of these DNA-methylation changes as well as their cellular and system level consequences.  Finally we will use expression quantitative trait locus analysis for GR stimulated gene expression to identify new loci relevant for GxE interactions in stress-related disorders.Overall, this proposal will follow up on one of the first putative molecular and systemic mechanisms identified for gene x environment interactions in affective disorders and will establish an animal model mimicking these specific interactions. The findings related to this proposal could be of major importance for understanding the biology of these disorders and to explore novel treatment options, including manipulations of epigenetic modifications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Getting at the Heart of Things: Towards Expressivity-aware Computer Systems in Music' under Horizon 2020.

assistant: **Concept**

What makes music so important, what can make a performance so special and stirring? It is the things the music expresses, the emotions it induces, the associations it evokes, the drama and characters it portrays. The sources of this expressivity are manifold: the music itself, its structure, orchestration, personal associations, social settings, but also – and very importantly – the act of performance, the interpretation and expressive intentions made explicit by the musicians through nuances in timing, dynamics etc.Thanks to research in fields like Music Information Research (MIR), computers can do many useful things with music, from beat and rhythm detection to song identification and tracking. However, they are still far from grasping the essence of music: they cannot tell whether a performance expresses playfulness or ennui, solemnity or gaiety, determination or uncertainty; they cannot produce music with a desired expressive quality; they cannot interact with human musicians in a truly musical way, recognising and responding to the expressive intentions implied in their playing.The project is about developing machines that are aware of certain dimensions of expressivity, specifically in the domain of (classical) music, where expressivity is both essential and – at least as far as it relates to the act of performance – can be traced back to well-defined and measurable parametric dimensions (such as timing, dynamics, articulation). We will develop systems that can recognise, characterise, search music by expressive aspects, generate, modify, and react to expressive qualities in music. To do so, we will (1) bring together the fields of AI, Machine Learning, MIR and Music Performance Research; (2) integrate theories from Musicology to build more well-founded models of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Out-of-equilibrium nanophotonics' (OUTNANO) targeting Horizon 2020.

assistant: **Abstract**

OUTNANO is about developing a new generation of nanophotonic devices by exploiting ultrafast dynamics of electrons driven out-of-equilibrium.Photonic sciences profoundly impact our society, enabling the development of high-technology devices that are currently employed in our daily life: DVD players, LEDs, laser printers, barcode scanners, displays, sensors, optical fibres, medical equipment and many others.Among the future frontiers of photonics, the achievement of ultraviolet lasers, compact white-light sources, and on-the-chip signal processing play a crucial role for several applications, e.g., all-optical computing, spectroscopy, imaging techniques, bio-sensing, cancer treatment, dental surgery, and micro-machining.Extreme exploitation of optical nonlinearities in nanophotonic components is fundamentally important in tackling these challenges, as frequency conversion mechanisms can be enhanced to generate ultraviolet radiation. Besides, optical nonlinearity enables active controlling of light by means of light, a basic requirement for developing all-optical devices. The high field enhancement provided by plasmonic materials and metamaterials is crucial for the full exploitation of nonlinear effects. Currently, the inherent high losses of these materials hamper their efficiency and their application in new-generation photonic devices.OUTNANO aims at tackling these challenges of nanophotonics by using ultrashort optical pulses with time duration of few femtoseconds, which drive the out-of-equilibrium electron plasma in the collisionless regime, where ohmic losses are suppressed. This novel regime enables the development of low-loss plasmonic circuits for on-chip all-optical computing and the engineering of highly nonlinear nanophotonic devices with enhanced efficienc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Feasibility study on biofuel chains implementation in a mediterranean country' (BIOPOR) targeting Fourth Framework.

assistant: **Abstract**

The aim of the BIOPOR project is the overall analysis of the factors affecting the creation and development of an agro-industrial production chain of liquid fuel for transportation purposes. Addressed issues include the evaluation of the role of the specific factors conditioning the production of vegetable species for biofuel, identification of by-products and their uses, study of production technologies, analysis of the economics of the process, establishment of  the environmental balance, conduction of a comparative study of alternative production systems, determination of the dimensions of the market, study of the transformation technologies involved, study of process integration into existing facilities, evaluation of market perspectives, establishment of the economic feasibility study, identification of existing limitations to biofuel usage in public transportation, technical and economic feasibility study of the use of biofuel in public transportation vehicles, establishment of the global energy balance and quantification of the socio-economic and environmental effects of the biofuel production chain in comparison with the results obtained from the use of conventional fuels.Expected achievements include: rapeseed and sunflower yields, crops economics, social, crops characterization, validation of simulation models, valorization strategies for the co-products, comparison of production technologies, utilization of experimental fields for data collection and for demonstration and dissemination purposes, market characterization, evaluation of the different transformation technologies, definition of optimization techniques, adequacy to transportation industry requirements, compliance with existing standards, identification of fuel improvements, pilot biofuel production
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NO-GO: UNVEILING THE POWER OF C-08 FOR THE TREATMENT OF OVER ACTIVE BLADDER' to be submitted under Horizon 2020.

assistant: **Abstract**

Over Active Bladder (OAB) is a syndrome characterized by several urinary symptoms, like urgency and nocturia. Prevalence is >10% of the population, 500 million people worldwide, and increases with age (>30% over 75 years old). OAB has psychological consequences such as embarrassment, impaired social interactions, depression and anxiety. Current pharmacological treatments for OAB are associated with multiple side effects and 80% dropout rates within 1 year. At Saga Natura we have developed NO-GO, a natural product for improving OAB symptoms, made from the leaves of the Icelandic plant Angelica archangelica. NO-GO’s precursor SagaPro was launched on the market in 2005, becoming Iceland’s top-selling non-prescription urinary product. We have performed in vivo and in vitro characterization of SagaPro’s bladder relaxing effect and we have clinically validated SagaPro in a small-scale clinical trial on 66 OAB patients, demonstrating it’s efficiency and safety. In Phase 2 we want to fine-tune our formulation, increase and internalize our production capacity complying with ISO and GMP standards and extend our clinical validation. We will also regulate NO-GO through the EFSA to obtain health claims. This way we will be prepared for our product’s mass expansion in Europe and in North America starting in 2021. This project will create 21 new jobs and profits of €108 Million with ROI of 16.6 after 5 years on the market. End-users will benefit from improvement of symptoms, no side effects, and ability to lead a normal every day life. Doctors will be able to recommend NO-GO to their OAB patients, a product with no side effects, and healthcare bodies will save costs on expensive OAB prescription drugs with too high dropout rates. Finally, with our sustainable approach for cultivating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Can chromosome reorganisation aid adaptation to drought?' in the context of a Horizon 2020 call.

assistant: **Objectives**

The structure and function of plant genomes have been marked by a history of repeated cycles of whole genome duplications followed by diploidization. Despite the number of duplications in their ancestry, most extant plants, particularly herbaceous groups, exhibit low chromosome numbers (e.g. five pairs in Arabidopsis), but the drivers of this descending dysploidy remain little understood. The project will test a classical hypothesis from early in the last century that chromosomal reorganization is driven by selection to create linkage groups favourable for a particular habitat. To address this, I will focus on Nicotiana sect. Suaveolentes, a group with variable ecologies, including adaptation to deserts, and series of chromosome reductions. I will focus of species pairs including a species with higher chromosome number that prefers mesic habitats, and a related species with lower chromosome number that is adapted to extreme arid conditions. I plan to investigate if genes responsible for adaptation to extreme habitats are associated with genomic rearrangements, and in particular test if these genes tend to cluster within fewer linkage blocks than expected by chance. This action will obtain a comprehensive understanding about the contributions of post-WGD processes to evolutionary success and phenotypic novelty, providing new information on how genomic reorganization contributes to adaptation, speciation and adaptive radiation. It will also provide details on genes associated with adaptation to hot, dry habitats, important for understanding plant responses to climate change.


**Keywords:** plant genomes,  polyploidy,  chromosome number change,  adaptation to drought,  photosynthesis,  demography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Characterisation and design of RNA-lipid interactions for RNA therapeutics'.

assistant: **Objectives**

RNA is a ubiquitous biomolecule with a broad range of activities crucial for keeping cells alive. Understanding how RNA bioactivity is controlled is vital for elucidating its roles and applications in molecular biology. RNA, in order to maintain a correct activity patterns, has to be organized. Despite sufficient knowledge about RNA spatial organization within cells via RNA-protein interaction-based processes not much is known about other mechanisms. Revealing the RNA-localization patterns without RNA-binding proteins would create the new branch of interactomics which might have significant implications in the molecular biology and RNA-based therapeutics development.Recently I described that lipid membranes can act as a scaffold for RNAs in a sequence and structure dependent binding process leading to the changes of the RNA activity in vitro. Here, I propose that lipid membranes act as a selective RNA scaffold in vivo. In the following project I will develop a library of membrane-binding RNAs using in vitro selection approach. I will characterize the mechanisms, selectivity, and stability of RNA-lipid binding in bulk and in nano-scale level using self-developed binding assays and super-resolution microscopy, respectively. Furthermore, obtained lipid-binding RNAs are going to be artificially introduced to the existing mRNAs in order to spatially organize protein expression both in vitro and in vivo. The RNA RNA-lipid encapsulation efficiency will be characterized using recently developed single-particle profiling platform. Lastly, I will use gathered knowledge to livetrack the uptake and improve the RNA-based therapeutics (i.e. RNA-lipid nanoparticles) in order to increase the RNA stability and decrease the toxicity of the formulation.


**Keywords:** Lipid membranes, RN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spatial Quantum Optical Annealer for Spin Hamiltonians' in the context of a Horizon Europe call.

assistant: **Objectives**

Optical simulators rank among the most promising candidates to power future technological breakthroughs in terms of speed,scalability, power-consumption and quantum advantage, serving a wide range of useful optimization problems. However, theoperation of such simulators remains currently limited by noise, the extent of algorithmic problems they can embed and to theclassical regime where they compete with supercomputers. HEISINGBERG aims to bring our state-of-the-art spatial photonic spinsimulator (an iterated cycle of all-optical processing through a spatial light modulator that couples 10,000 spins) into the quantumregime by upgrading its coherent drive to squeezed light, making it fully programmable through vector-matrix multiplicationschemes, use of holography, ancillary spins & effective magnetic fields, and designing dedicated custom-tailored and purpose-builtalgorithms. The reduced fluctuations in one quadrature of the fields will allow us to scale up and optimize the performances of theexisting machine to bring it beyond the capabilities of both classical supercomputers and competing spin-simulators. HEISINGBERGdevices will operate 100,000 spins at room temperature and process new quantum annealing algorithms on an improved XYarchitecture. Besides, the nonclassical resources of squeezed states when modulated, admixed and phase-controlled through beamsplitters, such as entanglement or superpositions of multiphoton states will be prospected to harness a quantum advantage andboost our machine into its quantum simulation regime. This development will stimulate the quantum information processingcommunity by concretely articulating problems of algorithmic complexity and clarify the nature of the quantum advantage availablein annealers and simulators. These advances wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evaluating current european agri-environment schemes to quantify and improve nature conservation efforts in agricultural landscapes' under Fifth Framework.

assistant: **Concept**

Environment-environment schemes play an increasingly important role in CAP to support biodiversity and environment in agricultural landscapes. They have been implemented since 1992. Still, there is no conclusive evidence that these schemes actually do contribute to the conservation of particularly biodiversity. The primary objective of this project is to evaluate the (cost-) effectiveness of European environment-environment schemes in protecting biodiversity and to determine the primary processes that determine their effectiveness. This project furthermore aims to determine how the CAP may be introduced in candidate EU-members without unacceptable loss of biodiversity. It will provide simple guidelines how researchers, governmental authorities or Shes may efficiently evaluate environmental-environmental measures.