RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrated materials management system' (IMMS).

assistant: **Concept**

The objectives of the IMMS project is to implement and evaluate a pilot re-engineered materials procurement business model for airline material stocks in KLM and Team Aer Lingus.The metrics of success or failure are defined in the research as specific cost saving goals in the process of procuring / disposing of airline technical stocks. The project is designed to address the problem of airlines sharing their surplus and excess stocks by providing the communications and information technology to trade among themselves in these stocks. Additionally the project will establish standards for the pricing of such parts and create a central agency to manage the process and achieve the benefits of economies of scale and buying leverage.The information system will use a window on the airline material buyer's screen providing him / her with access to all other participating airlines' designated excess / surplus stock. The end result of the development is a distributed information system providing the airline material buyer with on-line access to the excess / surplus stock held by all other airlines. Transactions to agreed pricing standards are immediately executable from the same screen.The re-engineered business process will differ from the current procurement process in the following principal areas:- it will provide access to stocks hitherto unavailable and it will provide agreed standard procedures and prices for inter-airline materials trading The net result will be a reduction in procurement costs and consequent increase in the cost effectiveness of the aircraft maintenance activity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Partnering Opportunities between Europe and China in the Renewable Energies and Environmental industries'.

assistant: **Innovation**

The research project aims at integrating and combining economic, legal and engineering competencies to analyze the level of economic cooperation reached so far between China and Europe in the renewable energy and the environment industries and to identify specific areas to boost partnership opportunities. Using a multi disciplinary approach, the exchanged staff will work on three main research areas.The first one is focused on trade and investment flows and aims at identifying critical issues, gaps, and potentials in Europe-China relationships. Major effects of Europe-China agreements on foreign direct investments (FDI) and trade flows are examined. Problems encountered and opportunities to be seized at firm level will also be analyzed. The economic perspective is supported and enriched by the engineering and legal perspectives. Engineering knowledge is fundamental to defining concretely the sectors, products and processes which have high deployment potential. Engineering research activity is focused on two main research areas, both related with energy efficiency and carbon dioxide reduction: mobility and the transportation sector and low carbon buildings. The legal knowledge is relevant to understanding obstacles due to the regulatory environment, as well as to identifying appropriate solutions to enhance collaboration. Main investigation areas will be: offshore oil and gas and renewable energy; anti-dumping; environmental and social standards and corporate social responsibility.POREEN aims at increasing the availability of interdisciplinary studies, with a comprehensive overview of Europe-China relations. Developing integrated knowledge is fundamental to provide useful and reliable information to support EU and local policymakers, as well as companies working in/with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Role of cohEsin dynamicS at sTAlled ReplicaTion forks' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Cohesin, an evolutionary conserved ring-shaped protein complex that topologically entraps DNA, has crucial roles in many structural and functional aspects of chromosomes including sister chromatid cohesion, genome organization, gene transcription and DNA repair. The importance of cohesin in the maintenance of genomic stability has been known for some time. Cohesin facilitates double strand breaks repair by homologous recombination and promotes the restart of stalled replication forks by template switching, an error-free DNA tolerance pathway. However, the precise role of cohesin in DNA damage and in the recovery after replication stress is still unknown. Whether cohesin acts exclusively providing close proximity of sister chromatids or its functions exceed simple embracing of DNA has yet to be discerned. Cohesin has been shown to be ubiquitylated upon replication fork arrest. This post-translational modification has been proposed to favour cohesin mobilization and subsequent association with nascent DNA behind the fork. However, the extent to what cohesin dynamics are important in the recovery after replication stress is still to be understood. By a range of multidisciplinary approaches, from biochemistry and enzymology, yeast genetics and molecular biology techniques to high throughput proteomics and bioinformatics analysis of mass spectrometry data, we will gain valuable insight about the interplay between sister chromatid cohesion and DNA damage tolerance and their contribution to successful replication. This basic knowledge about the mechanisms involved in DNA damage responses has demonstrated to be essential in the design of successful strategies against cancer. Remarkably, cohesin is one of the protein complexes most frequently mutated in cancer. This project aims
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Demonstrable and replicable cluster implementing systemic solutions through multilevel circular value chains for eco-efficient valorization of fishing and fish industries side-streams' (EcoeFISHent).

assistant: **Concept**

EcoeFISHent demonstrates a replicable systemic and sustainable cluster for territorial deployment of the climate-neutral circular economy by creating six multilevel and synergic circular value chains (CVC) interconnecting blue- and green-economies to reconcile human industrial and economic activities with marine ecosystems and marine protected areas. The EcoeFISHent innovative bio-mass pre-treatment and extraction technologies will enable sustainable and efficient exploitation of fish processing side-streams (FPS) by obtaining bio-actives and galantine for high value-added food supplements and skin care products, biodegradable and compostable barrier layer for food packaging. Other fishing- and fish-industry side-streams (FFS) will undergo the Black Soldier Fly bioconversion to yield innovative soil fertilizer, oil for biodiesel and chitin for cosmetic applications. End of life fishing nets from aquaculture and fisheries will be recycled and converted into automotive polymer-based components and into packaging for cosmetic products. The multilevel interconnected cluster will be managed by a cloud-based platform communicating with physical IoT systems enabling safe and efficient operation of the logistic and transport infrastructure. The cluster busines model and the cluster digital twin will allow simulating critical and optimal scenarios for quantitative analysis of cluster performance measured by dedicated KPIs, also enabling the assessment of the cluster replicability in other geographic areas and fostering investments pipelines. Community and stakeholder?s involvement will be promoted also in the implementation of specific actions for marine ecosystem preservation by modeling, application of better practices and technologies for strongly reducing by-catch and for st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Coordination and policy development in preparation for a European Open\nBiodiversity Knowledge Management System, addressing Acquisition,\nCuration, Synthesis, Interoperability and Dissemination' to be submitted under Seventh Framework.

assistant: **Abstract**

Biodiversity core data and information constitutes an important source of knowledge for many disciplines. In order to facilitate access to this knowledge, technical and semantic interoperability barriers need to be addressed.<br/>The objectives of Pro-iBiosphere are, to: a) Coordinate towards and prepare the foundations for a long-term viable, evolving knowledge management, aggregation and integration platform needed to replace and improve the present system of taxonomic literature, especially as presented in Floras and Faunas; b) Provide new methods to synthesize distributed knowledge and a strategy to adapt methods of acquisition, curation, and dissemination of biodiversity data to the digital era; c) Help to align ongoing and forthcoming semantic mark up of taxonomic literature, and to link elements of biodiversity literature (ie. taxonomic treatments) to the original data, such as the individual observation record (being the essential foundation of any biodiversity information); d) Promote and monitor the development and adoption of common mark up standards and specifications for making biodiversity knowledge more accessible and re-usable; e) Provide the community with technical solutions for the enhancement and use of these data; f) Analyze and evaluate business models for supporting Open Science and provide recommendations to achieve sustainable delivery of biodiversity information to target audiences; g) Develop and agree on a shared data and IPR policy; h) Promote and increase cooperation between the major biodiversity projects, initiatives and platforms at EU and global levels.<br/>These activities will prepare the ground for an integrative system for intelligent management of biodiversity knowledge. A system that facilitates open access to taxonomic data is es
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Linking Russia to the ERA: Coordination of MS´/AC´ S&T programmes towards and with Russia' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Major objectives of ERA.Net RUS are: • RAISING KNOWLEDGE on bilateral and national S&T programmes with or towards Russia and on relevant activities of other programme owners; IDENTIFYING STRENGTHS AND CHALLENGES of present bilateral S&T programmes of MS/AC with Russia. • LEARNING LESSONS from ongoing (thematic) ERA-NETs involving Russian programme owners and IDENTIFYING GOOD PRACTICE from other international ERA-NETs. • IDENTIFYING COMMON GROUND across bilateral S&T programmes of MS/AC with Russia and PROVIDING A BASIS FOR A JOINT PROGRAMMATIC APPROACH.  • DEVELOPING AN APPROPRIATE INSTRUMENTAL SETTING for joint funding activities  • TESTING A SCENARIO AND LEARNING LESSONS from a pilot joint call. • DEVELOPING AND PROMOTING A SUSTAINABLE JOINT PROGRAMME with Russia  In order to achieve these objectives ERA.Net RUS will  • implement a KNOWLEDGED BASED DIALOGUE BETWEEN PROGRAMME OWNERS IN EU MS, AC AND RUSSIA. • identify options for JOINT FUNDING ACTIVITIES OF PARTICULAR BENEFIT FOR PROGRAMME OWNERS IN EU MS/AC and develop respective IMPLEMENTATION SCENARIOS.  • implement a PILOT JOINT CALL of interested programme owners in EU MS/AC and Russia from inside and outside the project consortium and assess the effectiveness and efficiency of the joint funding scheme. • develop a SUSTAINABLE S&T (AND/OR INNOVATION) PROGRAMME to be agreed upon by interested programme owners from EU MS/AC and Russia. With respect to the work programme, ERA.Net RUS will: • facilitate MUTUAL LEARNING and drawing (joint) conclusions of programme owners • create SYNERGIES, increase impact, reinforce cooperation among S&T programmes and reduce fragmentation • facilitate the development and implementation of JOINT PROGRAMMES • allow LARGER NETWORKING in a wider European Research Area • address NEW EU ME
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structure-Function Studies of the TRIM Family of Ubiquitin E3 Ligases' in the context of a Seventh Framework call.

assistant: **Objectives**

Ubiquitin E3 enzymes participate in the last step of a three-enzyme cascade, where they transfer ubiquitin from E2 enzymes to substrates, therefore are responsible to bring the right substrate to the right E2 enzyme. The tripartite motif (TRIM) family of ubiquitin E3 ligases includes 70 members that are involved in cellular processes such as immune signaling, transcriptional regulation and apoptosis. Defects in TRIM E3 ligase activity have been linked to cancer and developmental and genetic diseases.  Despite TRIM vital roles, important aspects of their mechanism as E3 ligases remain unknown mainly due to their multi-domain architecture, their ability to self-associate into dimers and higher order complexes, and their ability to serve as E3 ligases not only for ubiquitin but also for ubiquitin-like proteins. We will pursue our interest in the molecular mechanism of TRIM E3 activity by working on TRIM25 that possesses dual E3 activity for ubiquitin and ubiquitin-like protein ISG15. We will determine the molecular mechanism of TRIM25 E3 activity using molecular biology, cell biology, crystallography and biochemistry. Specifically, we will map the contribution of TRIM25 different domains and the oligomineric state to its E3 activity. Then, together with crystal structures of TRIM25 with its cognate E2, UBCH8, charged with ubiquitin or ISG15, we will provide structural insight on how TRIM25 works in concert with UBCH8 and possesses dual E3 activity. In addition, we will determine how TRIM25 interacts with its substrate, 14-3-3σ, and whether the oligomeric state is important for substrate binding. Since 14-3-3σ undergoes ubiquitination and ISGylation by TRIM25 we will investigate the potential crosstalk between modifications. Specifically, we will test for the formation of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'VIMSEN: Virtual Microgrids for Smart Energy Networks' (VIMSEN), addressing dissemination and exploitation.

assistant: **Impact**

The subsidy feed in tariff policy, which has recently been adopted for accelerating renewable energy investments, cannot be retained as a sustainable business model for the future smart energy grid. This is mainly because this policy increases the energy cost, especially when the amount of the energy generated by renewable sources is not negligible compared to that generated by traditional ones, as is expected to be the case in the near future. Additionally, the current centralized electricity market prevents small or very small energy producers, who usually generate energy by renewable means (e.g., photovoltaic units or wind turbines), to participate. VIMSEN addresses the aforementioned difficulties by transforming the current centralized electricity market framework into a distributed one, introducing the concept of virtual micro-grid networks. Virtual micro-grids (VMGs) are associations of distributed energy generators and/or micro-grid networks that have agreed to operate on a common basis. VMGs provides flexibility to small or very small energy generators, since, i) they can re-distribute energy resources with each other to compensate energy production-distribution, and ii) they can directly participate in the electricity market through the respective association, which acts similarly as a big power generator unit. VIMSEN researches i) on an intelligent data metering techniques suitable for the VMG distributed network, ii) on information and decision making technologies for the dynamic VMG creation in a way to optimize the participants' benefits and macro-grid perspectives, iii) on a reliable communication infrastructure that permits Quality of Service (QoS) provisioning for data exchange in the VMG network and iv) on an active energy management and control tool fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Subsurface', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Characterising the shallow subsurfaces is important to civil and geotechnical engineering and environmental applications that depend upon precise definitions of geomechanical and geohydrological properties. The conference will not only address problems facing Europe, but also provide impetus for global applications of European research. Research in subsurface characterisation is dispersed among scattered institutes. The goal is establishment of a network and one or more centres that provide the critical mass needed to realise the full potential of co-operation, synthesis, integration, and innovation for better predicting subsurface conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Regulation of extreme plasticity in planarian stem cells by mRNA modifications', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Planarians are freshwater flatworms that can regenerate any part of their body including an entire head. A single transplanted planarian pluripotent stem cell can rescue a lethally irradiated animal. Hence, the extreme plasticity of planarian stem cells (neoblasts) is critical for regeneration. Despite intensive research, we still do not understand how cellular mechanisms that regulate neoblast homeostasis are integrated to facilitate regeneration. In a preliminary study, I discovered that chemical modifications of nucleic acids are critical for normal neoblast function, and that animals lacking this activity fail to regenerate. This extreme neoblast phenotype suggests that these highly conserved base modifications are crucial regulators of stem cell homeostasis. In this project, I will dissect the functions of nucleic acid base modifications in vivo using high-throughput gene function screening, single cell RNA sequencing, and molecular biology methods. I will establish a mechanistic foundation for understanding the regulation of stem cell plasticity and regeneration. In particular, we will (1) analyze the functions of genes encoding nucleic acid modifiers and use planarians as a platform for discovery of unknown players, (2) elucidate the regulatory roles of the base modification machinery on stem cell function, (3) investigate the dynamics of nucleic acid base modification landscape in planarian stem cell physiology and injury. My approach will generate a systems level understanding of nucleic acid modification-based regulation on stem cell homeostasis, an emerging theme in stem cell research. The impact of these findings are far reaching and would become the basis for a deeper understanding of fundamental stem cell biology, including mammalian physiology and patholo