RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Demonstration of water loops with innovative regenerative business models for the Mediterranean region' under Horizon 2020.

assistant: **Concept**

HYDROUSA will provide innovative, regenerative and circular solutions for (1) nature-based water management of Mediterranean coastal areas, closing water loops; (2) nutrient management, boosting the agricultural and energy profile; and (3) local economies, based on circular value chains. The services provided lead to a win-win-win situation for the economy, environment and community within the water-energy-food-employment nexus.HYDROUSA water loops will include water from non-conventional sources including wastewater, rainwater, seawater, groundwater and vapour water, all resulting in recovered and marketable products. HYDROUSA will demonstrate at large scale the feasibility and sustainability of innovative, low-cost water treatment technologies to recover freshwater, nutrients and energy from wastewater, salt and freshwater from seawater, and freshwater from atmospheric water vapour. Water conservation solutions including aquifer storage and sustainable agricultural practices including fertigation will be applied. The solutions will be demonstrated on 3 major touristic islands in Greece. Detailed technical and financial deployment plans will be established for replication in additional 25 locations worldwide. Through the on-site water loops of HYDROUSA, complex supply chains for resource recovery are not required, as producers are directly involved as consumers of derived products. HYDROUSA will combine traditional skilled workmanship with modern ICT integration in beautiful and smart automation systems. HYDROUSA will revolutionise water value chains in Mediterranean areas and beyond, from water abstraction to sewage treatment and reuse. The proposed HYDROUSA solutions show massive potential to change the way humans interact with water, food and energy.


**Keywords:**
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'HCA|Organoid: Pilot action to establish a multi-tissue human organoid platform within the Human Cell Atlas as a booster of future disease-centric, mechanistic, and translational research'.

assistant: **Concept**

Excellence: The Human Cell Atlas (HCA) is descriptive by definition, as it seeks to map all cells in the human body. Yet its goal of “understanding fundamental human biological processes and diagnosing, monitoring, and treating disease” (HCA Whitepaper) depends on our ability to draw functional/causal/mechanistic conclusions relevant to human diseases. Personalized organoid technology aptly fills this gap, as it makes human tissue amenable to functional studies and faithful disease modeling in vitro.This project will firmly establish a ""Human Organoid Atlas"" within the HCA. Initially focusing on two organs (colon and brain: 100 distinct organoid lines each). We will establish single-cell transcriptomes, single-cell epigenomes, and time-series imaging for several thousand organoids and matched primary tissue. This resource will primarily quantify normal population variation and provide a baseline for disease studies. Moreover, the project will include data generation and analysis of >20 colorectal cancer organoid lines with matching organoid lines derived from normal (healthy) material as well as the respective matching primary tissue. We will show the practical utility of the resource by proof-of-concept disease modeling for genetic epilepsy (brain) and large-scale characterization of disease-linked genetic variants (colon).Impact: 1. Deeply characterized organoid collection enables functional and disease-centric studies pursuing HCA insights. 2. Single-cell dataset provides reference of population variation under highly standardized conditions. 3. Linking single-cell profiling and organoids will boost HCA’s impact on human health.Implementation: The project connects the European founders of organoid research (Hans Clevers, Jürgen Knoblich) with expertise in large-sca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Laser supported cooling system manufacturing in mould production'.

assistant: **Objectives**

Over the long period of mould production, the designers and producers of moulds, as well as molders, are trying to use different technologies for achieving the optimal product quality. Only the integration of modern CAE technologies, rapid prototyping and rapid tooling technologies into the real mould production can solve more and more demanding problems. The project will do the research of the implementation of fully integrated 3D cooling system in the mould, which will have the same distance form, the mould surface to the cooling line, since the conventional cooling lines are described as 2D lines. In case of 2D lines, the temperature field in the mould cavity is not uniform, what cause unpredictable deformation of the plastic part after ejection. With the help of this project, the molders, as the indirect end users, will have the opportunity to produce much safer products and the production will be increased as well. The mould makers, as direct end user of this technology, will be able to integrate sophisticate technology into the mould production and become more competitive in the world market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cell-to-cell variability during symmetry breaking in organoid development' under Horizon 2020.

assistant: **Concept**

Cell-to-cell variability is an inherent property of populations of cells. As a starting point for symmetry breaking events, it is also an essential building block for self-organised pattern forming systems. Nonetheless, the sources and roles of cell-to-cell variability in symmetry-breaking events during collective cell behavior await a quantitative and mechanistic understanding. To obtain these insights, we will use a model system of intestinal organoids, which recapitulates most of the processes of morphogenesis and patterning observed in intestinal tissue. In this system, the symmetry-breaking event is observed when, despite all single cells in a growing organoid are exposed to uniform environments, only a fraction of cells acquires specific cell fates, generating asymmetric structures such as crypts and villi. This project aims to uncover the extent, sources, and consequences of cell heterogeneity. To this end, we will use advanced multiplexed imaging of intestinal stem cells in 3D organoid development to monitor quantitatively the behaviour of each single cell in the system. Initially, we will identify potential sources of cell-to-cell variability, such as the microenvironment or the cell cycle. Next, we will create models to identify predictors of symmetry breaking and patterning. In parallel, we will determine the extent of cellular heterogeneity by single-cell RNA sequencing during organoid formation. Finally, we will test if cellular heterogeneity is necessary and sufficient to induce symmetry-breaking of intestinal organoids by experimentally inducing and perturbing cell-to-cell variability. Thus, this research proposal will address a major question in developmental biology and collective cell behavior, namely how single cells exposed to a uniform growth-promot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel anaerobes for a biobased economy' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Our current society depends on many natural resources, and the availability of these natural resources (minerals, fossil fuels) is becoming more and more limited. The challenge of a sustainable and biobased economy is to develop innovative technologies to recover and reuse minerals and energy-rich compounds from waste streams and non-food agricultural crops. Microorganisms can be exploited for biotechnological purposes.The aim of this project is to study novel anaerobic microorganisms that:1.  Degrade and grow with biopolymers (polysaccharides and lipids),2.  Produce high value products (succinate and long chain fatty acids),3.  Possess a metabolism that can be steered by hydrogen and/or electricity.Microbial diversity represents an enormous reservoir of novel catalysts that can be exploited for a biobased economy. Molecular ecological research has shown that the majority (> 95 %) of the microorganisms in Nature has not yet been cultured and characterized. Their function in geochemical cycles is unknown and their biotechnological potential unexploited. This also applies for methanogenic environments in which organic matter is converted to methane and carbon dioxide, via energy rich organic intermediates. Our understanding of the microbial interactions that take place in methane formation is still scarce, especially how fermentations are influenced by hydrogen. In methanogenic environments fermentative anaerobes are present that produce valuable organic compounds, which should be exploited.Novel anaerobes can be isolated by intelligent and innovative isolation approaches, such as the MicroDish method. This method is currently adapted in my group for high throughput screening of strict anaerobes. The genomes of selected strains will be sequenced, followed by proteomics to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Personal Perception' (PEPE) under Seventh Framework.

assistant: **Objectives**

The project aims to open-up a new research field concerned with how human visual perception operates in a social context, and involves an innovative link between cognitive and social psychology. In particular, the project assesses how personal social interests permeate the functional and neural processes supporting human visual perception. The proposal is built around emerging findings from my laboratory showing that it is possible to experimentally ‘tag’ stimuli with personal-related (e.g., self-linked) associations, which enhance subsequent stimulus processing. The tagged stimuli can then be used to probe specific functional stages and brain mechanisms mediating visual perception, taking us beyond the view of perception as a purely bottom-up module to a new view of perception as tuned to personal self-interest.The project will provide a coherent programme of research using inter-disciplinary and state-of-the-art methods to assess (i) which functional processes in perception are affected by self-related biases, (ii) whether the effects occur automatically and even prior to the engagement of visual attention; (iii) the neural substrates of these effects (the neural localization, connectivity and necessary  role of different brain regions); (iv) how self-prioritization is modulated by culture, (v) the developmental trajectory of self-prioritization in perception (when does self-prioritized perception occur in children? are the critical factors the same as in adults? does self-prioritization  in perception increase in older adults?) and (vi) what factors determine the effects (what are the causal drivers of self-prioritized perception? reward? shared values? empathy?). By marrying together research from perceptual and social psychology, the project will offer a new over-a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Finding the Ghost in the Genome: Assessing the contribution of epigenetics to environmental plasticity in the soil sentinel Lumbricus rubellus', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

It has been established that the epigenetic landscape (cytosine methylation, histone modification and non coding RNAs) impacts on the underlying genomic architecture thereby regulating the transcriptional machinery and modifying gene expression. These elegant mechanisms of control influence tissue differentiation, organism life spam and can coordinate biochemical pathways responses to stressors such as UV light and elevated metal ion concentrations. It is the aim of this project to test the overarching hypothesis that:“Alterations in the epigenetic landscape caused by exposure to environmental contaminants directly modulate the expression of specific genes increasing phenotypic plasticity and providing the mechanistic basis underpinning the organism’s responses to the stress inducing causative stimuli.”We will test this hypothesis using, the epigeic earthworm L. rubellus, establishing it as a model to study the interactions between the environment and the epigenome.The experiment plan is designed to derive a causative relationship between modifications in the epigenome and the ability of an organism to tolerate specific environmental challenges. The project will primarily exploit metals/metalloids (Ni & As) with a mechanism-of-action with postulated impact on the epigenome, but the wider aim is to establish a new paradigm between the epigenetic landscape and the environment.The training programme will put great emphasis on exploring the opportunities provided by next generation sequencing technologies and the rich genomic resource provided by our target organism. This will require training in the technical, bioinformatics and informative frame works that will enable the production of a refined physical map of the earthworm epigenomic landscape. The training will exploit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'REConneCteD: Risk-Enhanced Community Care After Discharge' (SDx) under Horizon Europe.

assistant: **Objectives**

Children returning home after hospitalization for severe infectious illnesses suffer high mortality rates, especially in sub-Saharan Africa (SSA). After returning home, continued engagement with the health system can improve recovery and reduce post-discharge deaths. Yet, it is not feasible for every child to return to the hospital for follow-up care post-discharge. Community health workers (CHWs) can facilitate safer transitions in care by engaging with families after they return home and providing re-referrals back to higher levels of care if needed. Risk-enhanced care uses digital algorithms to provide the most appropriate intensity of care to each child depending on the estimated risk of an outcome. Embedding risk-enhanced care in SSA’s increasingly digitized health system provides an opportunity to increase the efficiency and effectiveness of health services provided by CHWs. However, digital health platforms used by CHWs in SSA do not currently communicate with digital health platforms used by facilities, creating a missed opportunity for ensuring continuity of care for vulnerable families. Here, we aim to embed our clinically-validated, risk-enhanced care approach into an existing electronic community health information system used by CHWs to create Risk-Enhanced Community Care after Discharge (REConneCteD). We will initially conduct formative research to develop and optimize the usability and accessibility of REConneCteD and then evaluate the impact of REConneCteD on post-discharge mortality in a clinical trial at 8 hospitals in Uganda and Kenya. We will also conduct a thorough economic evaluation. Our teams combines expertise and experience from community partners and researchers in Uganda, Kenya, and Canada (Walimu, KEMRI/Wellcome Trust, UBC, Brock University)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Representation and Processing of Pitch Variation in Tonal Languages' in the context of a Seventh Framework call.

assistant: **Objectives**

In connected speech, spoken words may vary considerably from their forms in isolation. Much of the variation is regular. There have been heated debates on whether and how speakers store regular variants in their long-term memory, and how they process them in speech production and comprehension. Most psycholinguistic work, however, focuses on how listeners cope with segmental variation. I propose instead to examine how speakers store and process regular pitch variation. My empirical focus is on Chinese dialects, where pitch changes (tones) are used to distinguish word meanings in isolation, but tonal realization of words in phrases is determined by domain formation and pitch changes within the domain, together known as tone sandhi. Crucially, both how a tonal domain is formed and how sandhi variants are realized within the domain are influenced by a complex mixture of pragmatic, syntactic, and phonological factors. The pitch variation in these dialects thus manifests at all levels of linguistic organization. I hypothesize that the way pitch variation is stored in the mental lexicon and processed during speech production varies according to the types of tone sandhi changes and the constituent structures of sandhi domains. I take an interdisciplinary approach to test this hypothesis. Cross-dialect speech corpora will be compiled to obtain a comprehensive understanding of how pitch variation is conditioned in linguistic contexts. Acoustic and perceptual experiments will be conducted to understand the categorical vs. gradient nature of pitch variation. Both voice onset latencies and speakers’ eye movements during speech will be monitored to tap into the representation as well as the processing of pitch variation. Results of this project will contribute to debates on represen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Externalities of energy: extension of accounting framework and policy applications (EXTERNE-POL)' (EXTERNE-POL), addressing dissemination and exploitation.

assistant: **Impact**

Objectives and problems to be solved:The objective of NewExt is to improve the assessment of externalities by providing new methodological elements for integration into the existing accounting framework of external costs. The external costs accounting framework developed by the ExternE projects has been widely accepted and successfully applied for support decision making in energy and environmental policy. However, there are areas, for which a need for further research was identified. Uncertainties result from lacking empirical data on the monetary valuation of mortality effects, from the omission of impacts on ecosystems due to acidification and eutrofication and from the insufficient knowledge about the impacts of global warming. In addition, contamination of water and soil and accidents in energy chains other than nuclear has not been taken into account. It is the aim of this project to close these gaps and so improve the quality of external cost estimates. Description of work: The work comprises the following four major work packages: An empirical survey is conducted in the UK, Italy and France on the monetary valuation of the reduction of life expectancy. With this survey, the valuation of chronic, latent and future mortality risks (one of the most important impacts related to energy fuel cycles) will be improved; the questionnaire elicits willingness to pay for avoiding reductions of life expectancy in Europe. The standard-price approach is introduced to complement the welfare-based estimates of externalities by taking into account abatement costs for achieving policy based environmental sustainability targets. This allows deriving external cost estimates for impact categories like impacts on ecosystem, which have not been covered in previous assessments of extern