RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reshuffling genes and genomes: from experimental evolution to synthetic biology in plants' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

GENEVOSYN has three highly ambitious objectives that will enable the engineering of new generations of crop plants. The project consists of three complementary workpackages (WPs) and will use both synthetic genomes and naturally available genomes as raw material for novel biotechnology and synthetic biology approaches. It will employ experimental gene and genome transfer as well as recently discovered natural (horizontal) genome transfer processes to generate new crop varieties and species. In WP1, the plastid (chloroplast) will be developed as a highly efficient platform for synthetic biology applications in plants. This will be accomplished by pursuing bottom-up and top-down synthetic biology approaches. They include the construction of large synthetic multigene operons towards introducing new complex metabolic pathways into plants, and the design, synthesis, assembly and booting up of radically redesigned synthetic genomes that ultimately will allow us to expand the genetic code and thereby the amino acid repertoire of plant cells. In WP2, GENEVOSYN aims at developing a technology for mitochondrial genome engineering in plants. The possibility to alter the genetic information in plant mitochondria by transformation would revolutionize both basic and applied research on plant mitochondria, and pave the way to harnessing the enormous potential of mitochondrial biotechnology. Finally, WP3 will exploit recently discovered horizontal genome transfer processes for the creation of novel crop species and the improvement of existing ones. To this end, we will use grafting-assisted horizontal genome transfer between crop species in the nightshade family (Solanaceae) to (i) generate new combinations of nuclear and plastid genomes and determine the impact of the plastid genome a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Clinico-pathological features and pathogenesis of fatal familial insomnia' (1994-1998).

assistant: **Innovation**

- To characterise in detail the clinical, laboratory and neuropathological features of Fatal Familial Insomnia (FFI), a rare hereditary human prion encephalopathy with a 178 codon mutation in the prion protein gene (PRNP) leading to prominent degeneration of the anteroventral (AV) and dorsomedian (DM) thalamic nuclei. - To correlate the spectrum of clinico-pathological features to the genetic background, in particular the codon 129 polymorphism in the PRNP. - To describe in the experimental animal the neural circuitry connecting the MD and AV thalamic nuclei to the cerebral cortex and other subcortical regions, in order to characterise neural pathways possibly relevant to the spread of prions.FFI is a rare hereditary disorder clinically characterised by early and intractable loss of sleep (insomnia), prominent autonomic activation with tachycardia, hypertension, diaphoresis, pyrexia and sphyncter loss, and motor impairment (ataxia, dysarthria, myoclonus, pyramidal signs). The disease is pathologically characterised by neuronal loss and gliosis in the MD and AV thalamic nuclei, and variable neuronal degeneration and spongiosis in the cerebral, especially frontal, temporal and parietal, and cerebellar cortex. The participants aim at defining the clinical and pathological features of such a disease by pooling all together the cases observed in France and in Italy (a total of 5 families) which have undergone a series of uniform investigations, in order to minimise the interfamilial variability and to establish a common definition of the disease and set certain diagnostic criteria. Accordingly, all the relevant clinical, laboratory and neuropathological features, when available, will be subjected to a detailed and quantified scrutiny in relation to the disease course. Possib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Forward-Models of Cosmic Dawn: connecting 21cm simulations to the real world' (FORWARD).

assistant: **Innovation**

FORWARD will enable a new generation of transformational probes of Cosmic Dawn (CD) to provide meaningful inference on key questions of galaxy formation. The CD contains some of the most sought-after insights into galaxy formation. Though these secrets remain locked away by a host of formidable real-world challenges, upcoming radio telescopes are optimistic. Interferometers such as HERA and future SKA, along with global experiments such as EDGES-3 are honed to observe the faint 21cm emission from neutral Hydrogen, redshifted to 50-150 MHz, in complementary ways. The dominant limitation of current experiments are spectral systematics that couple with overwhelmingly bright foregrounds. As we enter the regime in which the most extreme physical models begin to be ruled out by observations, meaningful inference of key parameters is most susceptible to inaccuracies in accounting for these systematics. Prior efforts to provide parameter constraints from CD have focused on forecasts, and treated systematics crudely and optimistically. FORWARD will synthesise the popular semi-numerical simulation code 21cmFAST and a radically overhauled parameter-inference engine, 21cmMC-2, with a series of new pluggable modules designed to efficiently forward-model the response of realistic interferometers, enabling the most direct comparison of theory to data. By applying this novel machinery jointly to observations from HERA and EDGES-3, we will (i) provide meaningful constraints on the parameters of galaxy formation during CD, (ii) build confidence in the reported detections, and (iii) enable future joint constraints from the SKA & EDGES-3. The framework developed will follow a legacy of code excellence, providing a bedrock for state-of-the-art developments over the coming years.


**Keyword
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tilt Rotor ATM Integrated Validation of Environmental Low Noise Procedures' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cleansky-Green Rotor Craft sub-project 5 is aimed at developing and testing new flight procedures for both helicopters and tilt rotors, aiming at significantly reduce environmental impact in terms of noise and gas emissions.This project contributes to this objective defining and validating, using an integrated Tilt Rotor-ATM simulation platform, new low noise ATC procedures for Tilt Rotor operations.Low-noise procedures in particular will require to accurately track possibly complex and steep trajectories both in take-off and landing, using optimized paths to avoid highly populated areas, using tilt rotors that have the potential to cruise speeds and altitudes compatible with fixed-wing traffic while taking-off and landing similarly to a conventional helicopter. Such a strategy heavily relies on advanced navigation and piloting aids to guarantee an acceptable level of pilot workload while retaining the benefits of the optimized paths.Moreover, future expansion of rotary-wing transportation will ask to fly in low visibility conditions under Instrumental Flight Rules (IFR), similarly to fixed-wing aircraft and using again sophisticated guidance means, as foreseen by SESAR, to ensure safety and low pilot workload. The transportation system will be strongly affected by the increased air traffic level and the need to control rotary-wing vehicles in IFR flight, in particular in terms of workload of the air traffic controllers.The ATM scenario models developed by this proposal will describe the ATM operations for approach and tower/ground control for a short-medium range mission with regard to a context using these new procedures developed for tilt rotors. The inclusion of initial findings of the SESAR initiative on trajectory management will represent another aspect of the in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Perceptual load and neural competition. Determinant factors in selective attention' (LOADATCMC08), addressing dissemination and exploitation.

assistant: **Impact**

Perceptual load theory has been credited with solving the long-standing debate in Psychology about the locus of selection. According with this theory, the degree to which distracting information can be ignored depends on the perceptual load of the task, or the extent to which the task exhausts perceptual capacity. However, there is currently no a priori definition of what constitutes high or low perceptual load. Here I propose a new framework to formalize perceptual resources according to the local competitive interactions that happen in the visual cortex and that modulate the representation of the information. I aim to explore the role of these competitive interactions in determining attentional selection. Moreover, I propose to investigate the neural mechanisms underlying perceptual load-based selection. The proposal represents a novel approach to the study of selective processing and limits of capacity in the human brain by integrating behavioral, fMRI and TMS methods
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Construction Grammar meets Typology: From Theory to Teaching' (Constructions).

assistant: **Concept**

The world’s languages differ in how they conceptualize events central to the human experience, such as motion and change of state, by means of constructions. This project investigates the expression of these meanings in four major European languages, English, German, Polish and Spanish. The aim is (i) to identify, through a fine-grained study of corpus data, the language-internal factors (semantic, morpho-syntactic, etc.) underlying cross-linguistic variation, including differences that can be observed in languages considered to be typologically related and (ii) to implement the findings in foreign language acquisition by developing a comprehensive pedagogical grammar of constructions. Consistently, this proposal involves three main phases. The first one consists of data collection and description. The second one is dedicated to data interpretation in the light of the theories concerned with verbal constructions and typological variation, namely Construction Grammar (Goldberg 1995) and Talmy’s (2000) typology of macro-events. In particular, it will be claimed that the typology of languages, as proposed by Talmy (2000), is in fact an epiphenomenon of a typology of constructions whose distribution in the world’s languages is constrained, among others, by the availability of grammatical devices, such as verb prefixes, verb particles, prepositions, etc. The third phase proceeds with translating the theoretical results into a user-friendly multi-lingual grammar of constructions, which permits to elucidate certain high-level morpho-syntactic generalizations, invisible in the prevailing verb-centred teaching materials. Therefore, the findings of this investigation would be an innovative contribution both to the theoretical debate on linguistic diversity and to the cross-lingui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fundus autofluorescence, visual function, and quality of life in patients with age-related macular degeneration' to be submitted under Fifth Framework.

assistant: **Abstract**

I know the applicant since July 1 st 1995, when she began an 1 1/2 year-research fellowship at the Department of Ophthalmology, University of Heidelberg. She was subsequently trained in our institution as a resident in Ophthalmology. During her time in Heidelberg she was permanently involved in various, focussing on the pathogenesis and new therapeutic strategies in age-related macular degeneration (ARMD). I am pleased to recommend Dr. Bellmann to you enthusiastically. She is a delightful young lady of very superior intelligence and has an excellent educational and professional background. Her participation in our scientific and clinical behaviour and clinical endevour was outstanding. I would rank her in the top 5% of residents I have seen here at the University of Heidelberg. The training she will receive at the Institute of Ophthalmology / Moorfields Eye Hospital in London, one of the most excellent institutions for scientifically and clinical work in Ophtalmology worldwide, will be of enormous benefit for her future career and her contributions to vision research. In 1992/1993 I had the opportunity to pass a 2-year fellowship at the Institute of Ophtalmology / Moorfields Eye Hospital in London. This formed a major base for all my subsequent work which also resulted in a successful proposal for The establishment of a concerted action program by the German Research Council (Deutsche Forschungsgemeinschaft) on ARMD. This covers clinical and basic research projects over the following 6 years of several cooperating groups throughout Germany. After the applicant's training in London we would very much like her to participate in the concerted action program on ARMD. Please don't hesitate to contact me any time, should any questions arise.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Immigrant's integration in several EU and non-EU countries: a time-use approach'.

assistant: **Objectives**

TIMEUSE aims to study the integration of immigrants for a wide range of EU and non-EU countries, by applying a new approach based on the time immigrants and natives allocate to daily activities. This objective will be achieved by: 1) investigating the differences between immigrants and natives in participation and in the time spent in integrating activities using parametric methods. In particular, the analysis will focus on differences between sub-groups of immigrants based on gender and other characteristics; 2) developing new metrics that analyse the relationships between integrating activities and how individuals distribute the time across activities. The analysis of the relationships between activities allows us to better understand deviations from desirable behaviour and inform policy actions aimed at removing constraints. The research will be based upon the use of highly detailed data on the time-use of a large sample of immigrants and natives residing in several EU countries, USA and Canada. In order to achieve this objective, I will be based at CESSMIR, an excellent centre in migration studies that is part of the Ghent University; an internationally renowned institution ranking among the 100 best universities in the world. Here, I will be trained in innovative and interdisciplinary methods applied to migration studies under the supervision of Prof. Glenn Rayp. Additional training on data management techniques will be provided by my secondment at CTUR, a world-leading centre that manages the data I will use in the analysis. The successful completion of training and research under TIMEUSE will greatly benefit my future career prospects in academia.


**Keywords:** Immigration, time-use, integration of migrants, network analysis, EU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Respiratory allergy and inflammation due to ambient particles - a european-wide assessment' (RAIAP) targeting Fifth Framework.

assistant: **Abstract**

PM10 and PM2, 5 ambient particulate fractions collected in Amsterdam, Lodi, Oslo and Rome and the Dutch sea-side will be characterised by physical-chemical and immunological parameters. The samples will be screened for respiratory allergic and inflammatory potential and positive findings will undergo verification in vivo respiratory allergic and inflammatory models. Mechanisms underlying modulation of molecular and cellular functions of the immune system, of signalling pathways in rat and human epithelial lung cell cultures, and of in vivo respiratory immune responses will be clarified. Mechanistic information is important for extrapolating the results from the experimental models to the human situation. The outcome of these studies will be communicated to policymakers, the public and industry as basis for preventive action.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Policy, practice and patient experience in the age of intensified data sourcing' under Horizon 2020.

assistant: **Concept**

The European healthcare services have begun collecting tissue samples and healthcare data from patients on an unprecedented scale. With POLICYAID we suggest the term 'intensified data sourcing' to describe these attempts at getting more data, on more people, of better quality while simultaneously making the data available for multiple uses. Data are used for research, for financial remuneration purposes, for quality assurance, to attract capital and even for police work. POLICYAID investigates how the diverse agendas interact in the making of a new infrastructure for healthcare. POLICYAID ambitiously aims to understand the drivers for and implications of intensified data sourcing in the biomedical realm across three levels: 1) policymaking, 2) everyday clinical practices, and 3) citizen experiences of health, illness, rights and duties. To achieve this aim we compare four different forms of intensified data sourcing, and analyze the regulatory frameworks guiding the data procurement and use in Denmark, the EU and beyond. Based on PI’s strong inter-disciplinary background and experience, we fuse legal, sociological, anthropological and public health scholarship and develop new methodologies for policy analysis by combining document analysis, interviews, participant observation and register-based methodologies. Instead of simply assuming that data sourcing can be reduced to matters of surveillance, we open up the black box of data sourcing by describing how data are selected; financed; what they are used for; how data practices relate to the involved stakeholders' hopes and concerns, and; who gains which rights to the data. We can thereby explore how intensified data sourcing affects clinical routines and patient experience, as well as understand how Big Data for medical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Human Brain Project'.

assistant: **Innovation**

The human brain can be seen as an immensely powerful, energy efficient, self-learning, self-repairing computer. If we could understand and mimic the way the brain works, we could revolutionize information technology, medicine and society. But to do so we have to bring together everything we know and everything we can learn about the inner workings of the brain's molecules, cells and circuits. The goal of the Human Brain Project (HBP) is to do this by integrating our knowledge in massive databases and in computer models of the brain. This will require breakthroughs in mathematics and software engineering and an international supercomputing facility more powerful than any before. This is all possible. Experimental and clinical data is accumulating exponentially. Computers powerful enough to meet the project's initial requirements are already here. An international team led by Europe's best neuroscientists, doctors, physicists, mathematicians, computer engineers and ethicists have assembled to begin the mission. As technology progresses and the project discovers new principles of brain design it will build ever more realistic models to probe ever deeper principles. The benefits for society will be huge, even before the HBP achieves its final goals. Models of the brain will revolutionize information technology, allowing us to design computers, robots, sensors, prosthetics and other devices far more powerful, more intelligent and more energy efficient than today. They will help us understand the root causes of brain diseases, and to diagnose them early, when they can still be treated. They will reduce reliance on animal testing and make it easier to develop new cures for brain disease. They will help us understand how the brain ages, and how to slow these changes and nurture