RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Personalized PREvention of Chronic DIseases' (PRECeDI), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the Personalized pREvention of Chronic DIseases consortium (PRECeDI) is to provide high-quality, multidisciplinary knowledge through training and research in Personalized Medicine (PM), with specific reference to prevention of chronic diseases. There is a large consensus that PM is a driver of innovation for research and health care, and also for the health care system and industry as a whole. In order to harness the potential of this new concept, the PRECeDI consortium provides a cohesive framework for training staff from academic and non-academic (NA) institutions on research topics related to PM, with specific reference to the prevention of chronic diseases where there is a lack of substantial evidence, though the potential is huge. The acquisition of skills from staff will come from dedicated secondments aimed at training on research topics not available at the home institutions, and attendance to courses, workshops, seminars, conferences. The goal of secondment is to enable staff to make informed decisions for appropriately serve health care systems, new biotech industries and policy makers at the dawn of the post-genomic eraPRECeDI  is a multidisciplinary group of institutions working on different facets of PM, from basic research, to economic evaluations, health service organization, and ethical, social, and policy issues. The consortium is embedded in existing cooperation structures, such as the PerMed project and the Erasmus Mundus ERAWEB II program, with additional leading SMEs in Europe and Canada as beneficiaries. The consortium consists of 8 beneficiaries and 3 partners, of which 7 are academic institutions and 4 NA, including 2 SMEs. During 4-years, 23 ESRs and 7 ERs will be seconded to 11 institutions, where researchers will be supported by a t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Compact, light, efficient and reliable turbo compressor for fuel cell vehicles' (Turbo-FuelCell) under Horizon 2020.

assistant: **Objectives**

The stronger regulation of carbon dioxide emissions, rising consumer awareness towards eco-friendly energy sources, and the need to minimize our dependency on fossil fuels are boosting the fuel cell electric vehicle (FCEV) market. Fuel cells need to be fed with a constant supply of oxygen, usually from air provided by a compressor. While much attention has been put on the fuel cell itself and the hydrogen storage, the oxygen supply has not been yet optimized. Currently, air management for fuel cell systems remains a challenge because today’s compressor technologies are not optimized for fuel cell applications. We are CELEROTON, a Swiss high-tech business at the forefront of high-speed turbo compressor technology. We are able to achieve speeds up to 300,000 rpm, which allows our product to be 20 times lighter and smaller than state-of-the-art compressors, while achieving the highest efficiency of all commercial compressors. Moreover, our compressor is 100% oil-free which results in the highest air purity, crucial to increase the fuel cell lifetime. Since our foundation in 2008, we have invested over 1.6M€ to develop our compressor technology up to near-commercial stage. Now, with project TURBO-FUELCELL, we aim to take the last technical and commercial steps to introduce our unique turbo compressor as the key technology for oxygen supply in the fuel cell vehicle market. This market with such growth potential (predicted to increase at 22.1% CAGR up to 2024 reaching 1.2 B€), could greatly benefit from the compactness and lightness of our product.  Our vision is contributing to the deployment of fuel cell vehicles in Europe, increasing their efficiency and decreasing their cost thanks to our compact, lightweight, quiet and reliable air compressor. We aim to achieve sales of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Oncometabolitic control of tumor growth and epileptogenesis in IDH mutated gliomas: D2HG signaling mechanism.'.

assistant: **Innovation**

Dysregulated growth processes of gliomas interact with pro-epileptic plasticity of brain circuits in such a way that the excitatory transmitter glutamate promotes autocrine tumor invasion as well as epileptic synchrony in surrounding cortical regions. Most low-grade gliomas are associated with mutations of Isocitrate DesHydrogenase (IDH) genes which lead to an excess of the oncometabolite D-2-Hydroxyglutarate (D2HG). With a structure mimicking glutamate, D2HG is thought to participate in both epileptogenic and oncologic processes. Importantly, while epileptic activity is accentuated, tumor prognosis is improved in affected people. My preliminary data now suggest a dual function for D2HG, acting as a glutamatergic agonist at high levels, but as an antagonist in the presence of glutamate. Solving this paradox will be a step forward in glioma science. The GliomasSignals project will examine the role of D2HG in the neurobiology of gliomas bringing electrophysiology concepts and tools to neuro-oncology, seeking to transform our understanding. It seeks to better understand how D2HG modulates glutamatergic signaling, affects neuronal excitability and tumor growth, and to detect the extent to which tumor infiltration colocalizes with epileptic remodeling.  In vivo and in vitro work mostly on human tissue will aim at: 1- Map biomarkers of epileptic activity / tumor infiltration by cortical recordings during surgery using unique next generation Neurogrid electrodes. 2- Correlate D2HG levels, glutamate concentrations and tumor infiltration with recordings in peritumoral cortex at an unprecedented resolution. 3- Identify D2HG effects on glutamate signaling in human tissue slices producing epileptic activities and in a rodent model. 4- Explore D2HG long-term effects on epileptic act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Preclinical validation of a novel immunogenic composition to stimulate innate immunity' (STIMUNITY) under Horizon 2020.

assistant: **Objectives**

Immunotherapy is a promising approach to treat cancer and infectious diseases, but innovative approaches are required.The cGAS-cGAMP-STING pathway can induce a potent immune response against viruses. It is also implicated in antitumoral immune responses that are effective. We have recently discovered that the small second messenger cGAMP can be packaged by viruses to stimulate immunity in target cells. We have developed methods to produce non-infectious virus-like particles containing cGAMP (cGAMP-VLPs) that strongly stimulate this innovative immune pathway. We will test the idea that cGAMP-VLPs are potent activators of anti-tumoral and anti-viral immunity. To reach this proof-of-concept, wepropose pre-clinical development plan in translational mouse models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scanning the potentialities for future ICT research collaboration between China and the European Union' under Sixth Framework.

assistant: **Concept**

SPICE will create a solid basis for future EU-China collaboration in information and communication technology (ICT) research by identifying and analysing potential topics and areas of research cooperation and initiatives between China and the European Union. The analysis and outcomes of SPICE will allow the European Commission (EC) to create targeted initiatives in thematic sub-areas of ICT.SPICE will identify common needs and opportunities for cooperative R&D based on strengths and clusters within ICT. SPICE will map competences and potentials of Chinese research organisations in the most promising regions / provinces through a consultation process based on workshops and data analyses. Also, representatives of European ICT companies that are already active in ICT research in China will contribute to this analysis using targeted interviews. Large events and conferences (e.g. the China High-Tech Fair) will inform Chinese organisations about the opportunities for ICT research collaboration in Europe and will support the collection of information through forums and workshops. Based on these findings SPICE will report China-EU constituencies and potentialities for deeper strategic cooperation" to the stakeholders.SPICE will also analyse for the EC the hurdles, barriers, and cornerstones that need to be addressed before European players engage in R&D collaborations with China. The project will present contacts with highly valuable partners in China to European actors. SPICE will further the participation of Chinese companies, universities and research centres in ICT research projects with European partners. It will lay the foundation for future funding of cooperation projects within FP7 by elaborating a strategy that is fit to the needs and aims of Chinese organisations. As
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'VIRTUAL & physical platform for Fuel Cell System development' (VIRTUAL-FCS) targeting Horizon 2020.

assistant: **Abstract**

Fuel cells have promise in transport applications ranging from busses to ocean ships where they are competing will other well-established technologies. As a complicated and disruptive technology, fuel cells require specialised knowledge to integrate into devices and systems. This is a huge barrier to fuel cell use in companies that don't have existing experience with, or confidence in fuel cell technologies.  The FC community needs to help system integrators develop and optimise fuel cell battery hybrid systems for varied applications.The overall vision of this project is to develop a fully open source software-hardware (cyber-physical) tool that can be adopted as a global standard for FC system design.  This platform will enable a system integrator at an SME, with limited fuel cell experience, to rapidly design a fuel cell battery hybrid powertrain for their specific application.  The platform will make this development as quick as for combustion or battery powertrains and give the integrator confidence that the system will meet their performance, reliability and durability requirements.This project will bring together a group of experienced fuel cell specialists to develop this platform (SINTEF, BALLARD and UBFC) along with several system integrators or end users of fuel cells who are leading organisations in their specific field, WESTCON (Maritime), BANKE (Heavy Duty Vehicles), VIVARAIL (Rail), SOLARIS (Busses).


**Keywords:** Fuel Cell Battery Hybrid Systems, Modelling, Simulation, Emulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Institutionalised care for people with mental disorders in South America: indicators and trends' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In the Caracas declaration of 1990, South American countries committed themselves to improve the human rights situation and social inclusion of people with mental disorders, de-institutionalise their care and develop community mental health services. There is however little evidence on the extent to which this has happened and what the current trends are. Indicators of institutionalised care include the provision of psychiatric hospital beds, forensic psychiatric beds, involuntary admission rates, supported housing, and residential homes. A particular question is how many people with mental disorders have been imprisoned, since the prison population increased substantially over the past decade (e.g. in Chile by more than 100%). The study has two aims 1) to assess indicators of institutionalised care for people with mental disorders across South America since 1990 and identify trends of de-, trans- or re-institutionalisation; 2) to establish the rate of people with mental disorders in a prison population in Chile. Primary data sources from ministries and social welfare, national prison administrations, hospital administrations and non-governmental organisations will be used to obtain indicators of institutionalised care. The prevalence of mental disorders in a prison population in Chile will be assessed in interviews of a representative sample of 800 prisoners. It is hypothesized that there is a trend towards trans-institutionalisation with a decrease of conventional hospital beds, but with high rates of people with mental disorders in prison and an increased provision of supported housing, whilst community services are still lacking. The findings will be explained against the background of societal, economic and professional developments in South America. The study will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Genetically Encoded Multicolor Reporter Systems For Multiplexed MRI' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In order to fully understand the complexity of biological processes that are reflected by simultaneous occurrences of intra and inter-cellular events, multiplexed imaging platforms are needed. Fluorescent reporter genes, with their “multicolor” imaging capabilities, have revolutionized science and their founders have been awarded the Nobel Prize. Nevertheless, the light signal source of these reporters, which restricts their use in deep tissues and in large animals (and potentially in humans), calls for alternatives. Reporter genes for MRI, although in their infancy, showed several exceptionalities, including the ability to longitudinal study the same subject with unlimited tissue penetration and to coregister information from reporter gene expression with high-resolution anatomical images. Inspired by the multicolor capabilities of optical reporter genes, this proposal aims to develop, optimize, and implement genetically engineered reporter systems for MRI with artificial “multicolor” characteristics. Capitalizing on (i) the Chemical Exchange Saturation Transfer (CEST)-MRI contrast mechanism that allows the use of small bioorganic molecules as MRI sensors, (ii) the frequency encoding, color-like features of CEST, and on (iii) enzyme engineering procedures that allow the optimization of enzymatic activity for a desired substrate, a “multicolor” genetically encoded MRI reporter system is proposed. By (a) synthesizing libraries of non-natural nucleosides (“reporter probes”) to generate artificially “colored” CEST contrast, and (b) performing directed evolution of deoxyribonucleoside kinase (dNK) enzymes (“reporter genes”) to phosphorylate those nucleosides, the “multicolor” genetically encoded MRI “reporter system” will be created. The orthogonally of the obtained pairs o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Targeting IRE1 in disease' (INSPIRED) under Horizon 2020.

assistant: **Objectives**

The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise, to develop new classes of therapeutics for these common diseases.  By fostering a shared culture of research, innovation and collaboration, the participants will accelerate advances in the field of cell stress responses. The staff members who participate in the programme will develop new skills, learn new technologies and be exposed to new environments which will considerably enhance their career opportunities.  Advancing drug development in the stress response field has potential translational and commercial opportunities for the participants and will benefit European society as a whole from economic and health perspectives.IRE1 is a stress sensor and signal transducer, activated in response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Its activation is part of a process termed the unfolded protein response (UPR) that determines the fate of cells in response to ER stress. The INSPIRED consortium  will focus on understanding IRE1 signalling and its role in the stress response in order to target it in specific diseases such as cancers and neurodegenerative disorders where aberrant IRE1 signalling occurs.  Research carried out by INSPIRED  partners will develop new IRE1 modulators and generate preclinical data to support targeting IRE1 in cancers and neurodegenerative disease.


**Keywords:** Endoplasmic Reticulum (ER), ER stress response, IRE1,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Human Bridge for Strengthening Integration of ICRC into European Research Area' to be submitted under Seventh Framework.

assistant: **Abstract**

International Clinical Research Centre (ICRC) is an emerging centre of excellence in the European Research Area (ERA). It is an innovative science and research centre and a top-quality public healthcare centre focusing on prevention, early detection and cure primarily of cardiovascular and neurological diseases. ICRC is based on almost ten years of successful cooperation between St. Anne ́s University Hospital in Brno and the Mayo Clinic in Rochester, Minnesota (USA). Increasingly, partnership with knowledgeable research institution in the EU is being built, however the integration to the European Research Area currently represents a week point of ICRC.The ambitious idea to establish ICRC materialized in 2010, after a successful application for funding under the Operational Program ""Research and Development for Innovation"" which is co-financed by the Structural funds of the European Union.The justification for such a massive investment from Structural Funds and national funds came mainly from our track-record in producing outstanding research results, both academic papers and applied results, in partnership with Mayo Clinic and University of Minnesota and their industrial partners. What our centre lacks so far is a stronger European dimension. For this very reason, we would like to use the opportunity offered through the RegPot funding for developing stronger ties with key European players relevant to our research focus, both academic institutions and industrial partners. Moreover we expect that the proposed project will enhance the RTD capacity and capability especially in the area of human potential, it will enhance ICRC innovation potential and improve visibility of ICRC.""