RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A cost-effective, out-of-the-box photon counting platform for multi-photon in vivo microscopy applications'.

assistant: **Innovation**

Multi-photon microscopy is the gold-standard brain imaging approach to study the brain and other organs in action and is used across hundreds of laboratories worldwide. The current attempts to imaging increasingly large tissue volumes pushed multi-photon microscopy into the photon-deprived regime (i.e. the dim conditions that result from moving faster allowing collection of less photons per pixel/voxel). Under these condition, the relative few photons detected can be lost in the electronics noise of the system. Photon-counting techniques overcome this hurdle yet its implementation requires either custom electronics (and electronics expertise) or the use of relative expensive commercial solutions that are not tailored for this type of imaging thus providing only a partial solution. Therefore there is an unmet need in the market today for an easy to implement photon counting solution that seamlessly integrates into existing imaging setups and provides all the required software to perform intravital multi-dimensional imaging. This project aims to commercialize PySight, an add-on hardware and software solution tailored exactly to fill this market gap. Moreover, the product I propose to develop here targets both the academic and medical sectors as multi-photon diagnostic are becoming more common nowadays. Beyond achieving the unmet needs, our prototype improves many aspects of imaging (such a neuronal population imaging in single and rapid volumetric imaging). Its spatio-temporal resolution outperforms top-tier imaging setups while retaining over 200 times lower data rates. Importantly, PySight requires no electronics expertise and its software is open-source.


**Keywords:** Neuroscience, multi-photon imaging, photon counting, volumetric imaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative' in the context of a Seventh Framework call.

assistant: **Objectives**

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Detection, survival and elimination of human enteric viruses in soft fruit.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The project will develop rapid and efficient methods to detect the presence of contaminating human enteric pathogenic viruses in soft fiuit. The methods will be based on differerential centrifugation for extraction of virus particles, cell culture for detection of infectious virus, and molecular detection for viruses such as Norwalk-like viruses which as yet cannot be cultured. The methods will be used to determine how long viruses can remain infectious in soft fruit, both fresh and frozen. The effect of commonly used sensitisation methods, such as chlorination, on viruses contaminating soft fruit will also be evaluated."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A European ce-based assessment tool for flexible and innovative Window systems' (ECWINS), addressing dissemination and exploitation.

assistant: **Impact**

Within three years time all windows have to be provided with a CE-mark. This means that the performance profile of windows in the whole EU will be uniformly determined. However, the introduction of CE-marking for windows will have a high impact on all local window-producing SMEs all over Europe: it requires the determination of the CE-performance profiles by testing for every window type. Because especially local SMEs manufacture a lot of unique window types, their production costs will rise clearly. This could result in the loss of employment for local SMEs mainly in rural areas, where more than 85% of the window manufacturers are located.Furthermore, by introduction of CE-marking, tradability and competitiveness in the EU should improved, but due to the different building legislations, processes and traditions in the EU-countries, this still prevents windows to be applied in another EU-country, even when they are CE-marked. The objectives of this proposal are to develop a CE-based window assessment tool that calculates the CE-performance characteristics with clearly less extensive physical testing and to develop a European window interface model that assesses the applicability of a CE-window in a specific project in the EU. To achieve the objectives sophisticated models have to be developed, in which essential window components, and different building processes, traditions and façade legislations in the EU are incorporated.The models will be developed on the condition that the assessment tool developed can be handled easy by SMEs by designing windows, and a complex version can be used for CE-assessment by notified bodies. The EU-interface model for windows will stimulate to share innovations in window design across the borders. As a result of the optimisation of local
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for ''UNMET' - Uncovering Mechanisms and Establishing Strategies to Target Vessel Co-Opted Colorectal Cancer Liver Metastases', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

An estimated 25-50% of colorectal cancer patients will encounter liver metastasis during their illness. Tumor vessel co-option is a non-angiogenic mechanism whereby tumors, rather than forming new blood vessels (a process known as angiogenic growth), hijack pre-existing blood vessels in the affected organ. Standard anti-angiogenic therapy (AAT) is ineffective against vessel co-optioned tumors. This process has been linked to unfavorable patient outcomes. The exact mechanisms distinguishing vessel co-option remain elusive. Preliminary data suggest that metastatic cancer displaying the vessel co-option phenotype increased in gene expression, regulated by Lymphoid enhancer binding factor 1 or LEF1 protein, which is a key mediator of the Wnt/-catenin signaling. The dysregulation of the Wnt pathway can activate target genes that promote cell proliferation and survival. In this proposal, I hypothesize, that inhibition of the Wnt signaling (e.g. by blocking LEF1), will change the properties of vessel co-optioned tumors and improve the effectiveness of conventional treatment for liver metastases. Patient-derived organoids, obtained from hospitals, will be used to validate whether the inhibition of LEF1 will impact the vessel co-option phenotype, making it more susceptible to AAT. Advanced microscopy techniques, like Atomic force microscopy and Scanning ion-conductance microscopy, will facilitate monitoring the decreased stiffness of vessel co-opted tumor cells, leading to improved AAT delivery. By using humanized patient-derived organoid xenografts with inhibited Wnt signaling, I will monitor tumor growth, its phenotype, and the response to AAT in vivo. Furthermore, I aim to pinpoint diagnostic markers for vessel co-option tumors using blood tests and computed tomography (CT) s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Renewable materials and healthy environments research and innovation centre of excellence' in the context of a Horizon 2020 call.

assistant: **Objectives**

Slovenia was identified as a region lagging in innovation within the Horizon2020 WIDESPREAD 2014-1: Teaming call for proposals, and this is is particularly noticeable in the country's forest-based value chain. However, the vital core of Slovenia’s renewable resource-based value chain has retained access to international markets and a significant production capacity in spite of an overall workforce reduction. Therefore this industry exhibits a strong potential for growth, which was identified in the Smart Specialization Strategy of Slovenia. The Smart Specialization Strategy of Slovenia calls for inter-sectoral networking and integration of the wood chain in the design of homes and working environments of the future. It promotes research and innovation deriving from traditional knowledge and skills related to wood and wood-compatible natural materials and seeks to increase added value and export of companies by 15% by 2023. In order to leverage this potential by facilitating collaborations between industry and academia in this sector, the Renewable materials and healthy environments research and innovation Centre of Excellence (InnoRenew CoE) was established. With support and guidance from the advanced partner, Fraunhofer WKI, scientific research and development activities will be transferred rapidly and effectively to the industry and through them to society in the form of innovative new products and processes.


**Keywords:** Renewable resources, renewable materials, building materials, building systems, built, environment, human well-being, innovation, living laboratory, ergonomic design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sensory/motor space' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Over the last years there have been more and more hints that the perception of motor actions might be supported by mechanisms that are very similar to those in control of these actions. This would make sense as both the perceptual and the control tasks share a large part of their computational problems. This series of meetings concerns the progress in the field of spatial coding, especially as it refers to our sense of motion and orientation, and as it leads to specific voluntary or reflex motor actions. We live in a three-dimensional world. Sensory inputs define our position in space and that of objects. Motor output is used for self- motion as well as for manipulation of objects. We experience one unique sensory space, which requires the fusion of visual, acoustic, somatosensory, vestibular, and other inputs.This is computationally a highly non-rivial process, as the sensory systems utilise different coding formats and co-ordinate frames. The first meeting will address the role of the cortex and the cerebellum in the generation of eye movements. Eye movements have been studied extensively as a model for sensory-motor transformations, because they are relatively simple movements, e.g. pure rotations, with a constant mass, and without intervening obstacles. The primary pathways for the generation of eye movements are within the brainstem and the midbrain. However, the role of cortical and cerebellar areas in the control of eye movements has recently received increasing attention. Their role in the plasticity and performance of eye movement generation is currently investigated at behavioural, electrophysiological and molecular level. The second meeting will focus on the computational mechanisms and strategies that allow us to generate and perceive movement and action in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'PRedictive mOdeling Of RAdiaTion-Induced CArdiotoxicity after breast cancer radiotherapy' (PRO-ORATICA).

assistant: **Innovation**

Breast cancer is the most common cancer among women worldwide. Radiotherapy (RT) is an essential component of the treatment for the majority of BC patients. Although the therapeutic benefit of RT is well-proven, it may be offset by secondary effects, such as cardiac toxicity, arising from the inevitable irradiation of healthy tissue. Increased cardiac morbidity and mortality rates are well documented after breast cancer RT, but the exact underlying mechanisms behind cardiac toxicity is still unclear. Such information is crucial to develop accurate predictive models of cardiotoxicity and to devise new strategies for personalized RT treatments, either by optimizing the existing protocols or by considering emerging RT techniques, such as proton beam therapy.The goal of PRO-ORATICA project, carried out by the researcher Eugenia Mylona, is to devise decision-making tools aimed at proposing integrative and feasible strategies for reducing radiation-induced cardiac complications after breast cancer RT. Novel image processing and analysis techniques will be applied to identify radio-sensitive cardiac regions, while artificial intelligence will be used to develop multivariable subregion-driven predictive models of cardiac toxicities. Strategies will be proposed for transferring the developed models to the clinics, offering optimized personalized treatments with reduced cardiac complications. This research project can be practice-changing as it may define new improved standards for the treatment of breast cancer, potentially enhancing patients’ quality-of-life.The fellowship will take place at Universidad Carlos III de Madrid (UC3M) under the supervision of Dr Javier Pascau, Associate Professor at the Bioengineering and Aerospace Engineering Department. As part of this project, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'COmplement Regulation and Variations in Opportunistic infectionS' (CORVOS).

assistant: **Concept**

Opportunistic infections are defined as infections caused by pathogens primarily affecting immunocompromised subjects. Due to the immunodeficiency, they are difficult to treat and together the top 2 killer worldwide. Opportunistic pathogens comprise bacteria, viruses, fungi and parasites.Complement as a chief conductor of innate immunity plays a crucial role in immune defence against opportunistic pathogens. Research in this field is exploding, but also suffers from poorly coordinated intersectoral training of early stage researchers (ESRs).CORVOS, for COmplement Regulation and Variation in Opportunistic infectionS will train 15 widely recruited and highly motivated ESRs. They will fill the current scientific gap in the understanding of the role of complement in opportunistic infections, and translate this knowledge into clinical practice. ESRs will become creative alumni, all with a jointly awarded Double PhD of two European universities and equipped with entrepreneurial and clinical skills, making them attractive human resources to academia and industry alike. CORVOS is an ambitious pan-European initiative of 10 European universities, 3 biomedical companies, 2 research institutes and 3 hospitals that comprises an interdisciplinary doctoral programme including cross-sectoral secondments and training in transferrable skills. CORVOS includes 12 internationally renowned multidisciplinary scientists, 8 of them members of the European Complement Network. This established organization will ensure that the high quality and efficient implementation of the CORVOS training programme will sustain after its funding and will be embedded into existing doctoral and research training programmes across Europe.Ultimately, CORVOS doctoral and research training programme enables intersect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mathematical modeling of anaesthetic action' (MATHANA) targeting Seventh Framework.

assistant: **Abstract**

General anaesthesia is an important method in today's hospital practice and especially in surgery. To supervise the depth of anaesthesia during surgery, the anaesthesist applies electroencephalography (EEG) and monitors the brain activity of the subject on the scalp. The applied monitoring machine calculates the change of the power spectrum of the brain signals to indicate the anaesthetic depth. This procedure is based on the finding that the concentration increase of the anaesthetic drug changes the EEG-power spectrum in a significant way. Although this procedure is applied world-wide, the underlying neural mechanism of the spectrum change is still unknown. The project aims to elucidate the underlying neural mechanism by a detailed investigating a mathematical model of neural populations.The investigation is based on analytical calculations in a neural population model of the cortex involving intrinsic neural properties of brain areas and feedback loops to other areas, such as the loop between the cortex and the thalamus. Currently, there are two proposed mechanisms for the charactertisic change of the power spectrum: a highly nonlinear jump in the activation (so-called phase transition) and a linear behavior. The project mainly focusses on the nonlinear jump to finally rule it out or support it. A subsequent comparison to previous experimenta results aims to fit the physiological parameters.  Since the cortex population is embedded into a network of other cortical areas and the thalamus, the corresponding analytical investigations takes into account external stochastic (from other brain areas) and time-periodic (thalamic) forces. To this end it is necessary to develop several novel nonlinear analysis technique of neural populations to derive the power spectrum close t