RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Migration timing genotype as a predictor of salmon vulnerability to environmental change' in the context of a Horizon 2020 call.

assistant: **Objectives**

As the global environment changes, species are increasingly suffering mismatches between their seasonally timed movements and the conditions that they encounter. The long-distance migrations of Atlantic salmon (Salmo salar) from their natal rivers to their marine feeding grounds and back again are a charismatic example of such seasonally timed movements. The timings of both the outward and return migrations are heritable, and vary substantially within and among populations, likely reflecting selection to enter the marine environment when survival conditions are optimal and return to the freshwater when breeding success is maximized. Importantly, salmon cannot observe the conditions at their destination and must rely on proximate cues, in particular photoperiod, to schedule their migration. Globally, salmon migrations have advanced over recent decades, suggesting that phenological mismatch could be a factor in ongoing Atlantic salmon declines.How and whether a species can adjust its migratory timing to match new conditions depends on the underlying genetic architecture of this timing. SAL-MOVE will establish a global collaborative network of salmon researchers, collate existing datasets, and apply state-of-the-art genomic analysis to characterize the environmental correlates and genetic basis of Atlantic salmon migration timing throughout its range. This information will be combined with future climate scenarios in an eco-evolutionary modelling framework to predict how Atlantic salmon populations will be impacted by anthropogenic change via their migration phenotypes and genotypes. Results from SAL-MOVE will be used to directly guide management actions intended to increase the security of wild Atlantic salmon.


**Keywords:** salmon, phenology, migration, genetic archite
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Reducing Early Atrophy with Leucine during Immobilization of Skeletal Muscle' (REALISM), addressing dissemination and exploitation.

assistant: **Impact**

Recovery from injury, illness, and/or disease is associated with skeletal muscle disuse. Muscle disuse leads to a loss of muscle mass, strength, and functional independence, and represents a “catabolic crisis” for the elderly who are already at a greater risk for low muscle mass and strength due to age-related sarcopenia. Muscle mass is determined by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). When MPB exceeds MPS, the result is a negative net protein balance and muscle loss. Decreased MPS rates occur following the onset of immobilization-induced disuse, but there is no information on the response of MPB. mRNA and protein expression data indicate that the early stages of disuse (0-5 days) result in activation of the ubiquitin proteasome system, and presumably MPB suggesting that the initial stages of disuse represent a critical period to intervene with appropriate countermeasures to attenuate the loss of muscle mass and strength. Leucine is a key amino acid in the regulation of muscle protein metabolism that has been shown to inhibit MPB. The current proposal REALISM will 1) identify whether MPB is elevated during the early stages (72 hours) of immobilization-induced disuse, 2) determine whether leucine can reduce MPB and the loss of muscle mass during the early stages of immobilization, and 3) determine whether leucine can preserve muscle mass and strength in the elderly during more prolonged periods of immobilization. REALISM will identify the mechanisms underlying disuse atrophy in response to immobilization and examine potential therapeutic strategies to offset the loss of muscle mass and strength. The M3 laboratory of Dr. van Loon at Maastricht University (UM) offers the most ideal environment for me to conduct REALISM, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The role of Ubiquitin System on the homeostatic control of stem cell maintenance and differentiation in crypt stem cells' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The epithelium of small intestine has a higher self-renewal rate than any other mammalian tissues. This is fuelled by the intestinal stem cells which reside near the bottom of crypt. Tight regulation of the adult stem cell number is required to sustain an adequately sized population for optimal tissue homeostasis. Mis-regulation of homeostasis results in either hyperplasia or loss of stem cells. Although transcriptional regulation of stem cell homeostasis regarding multipotency and differentiation has been extensively studied, only little is known about post-translational modifications. A key mechanism of post-translational modification is ubiquitination by the ubiquitin system (US).The in vitro primary intestinal organoid culture system recapitulates in vivo epithelium organization, is amenable to essentially all experimental technologies that have been developed for cell lines, and therefore serves as a novel, robust and powerful model system. Taking advantage of the intestinal organoids, this project is aimed to investigate the role of US on the homeostatic control of stem cell maintenance and differentiation in crypt stem cells by: 1. Screening of US required for stem cell number regulation by CRISPR/Cas9 technology; 2. Characterization of the expression pattern and sub-cellular localization of candidate US; 3. Examining the effect of candidate US in signalling pathways involved in the homeostatic control by reporter assay and target gene expression; 4. Identifying target proteins of candidate US using surface proteome analysis, IP-mass, BioID or in vitro ubiquitination of arrayed proteins; 5. Performing biochemical and cell biological analysis of candidate US with its identified target proteins and signalling pathway components in vitro; 6. Generation of conditiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Investigating microbial colonization and removal on dynamic patterned surfaces' (MOBILE).

assistant: **Innovation**

Microbes have remarkable capabilities to attach to surfaces of natural and artificial systems, eventually leading to the formation of biofilms and associated chronic and persistent infections. It is extremely appealing to understand how bacteria interact with three- dimensional surface topographies and how to design smart patterns as a strategy to create antifouling and biocidal materials. Here I propose a dynamic strategy, merging verstile and large-scale surface modification teqhniques based on mechanical wrinkling of soft bilayers, that I developed at Imperial College London, microfluidics and microbiology. The goal of MOBILE is investigating the mechanical confinement exerted by non-planar surface curvatures and spatial heterogeneities induced by fluid shear on bacterial initial attachment and removal, in confined environments. Specifically (Aim 1), I will evaluate the combined action of surface topography and fluid shear over bacterial proliferation, motitly and viability, incorporating nano- to micro-scaled wrinkled geometries in microfluidic channels, mimicking biological tissues surfaces and implantable medical devices, testing a series of different clinically relevant bacterial strains (such as Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae). I will also (Aim 2) develop antifouling and removal strategies by investigating the mechanical response of adhered bacteria, using patterned surfaces as stimuli-responsive probes ""actuated"" by means of mechanical deformation (i.e., by extension and compression of the wrinkled topographies) to induce detachment and surface cleaning under fluid dynamic conditions. Overall, I aim to elucidate new methodologies for bacterial removal at different stages of biof
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Gender Equality Actions in Research Institutions to traNsform Gender ROLES'.

assistant: **Concept**

Devising and implementing GEPs in higher education institutions or research centers is a formal requirement to enhance actions that favor real and effective equality between women and men. While this is a reality, its effectiveness is bound to a series of factors, like the suitability of the agents involved in its setting-up, the strategic alliances built, and the awareness raised on the potential resistances –both tangible and intangible- that are to be faced in its implementation and prevent real structural changes in these organisations. Every GEP should be understood as a process that is born out of the will to grow and become stronger so that equality between women and men can be promoted and legitimised. One way to maximize the effectiveness and efficiency of a GEP is to collect and incorporate the expertise, knowledge and experience of previous projects. For this reason, our project aims to implement 6 equality plans in 6 organizations (5 Universities and 1 Research Funding Organization) applying the criteria established and tested by GEAR-tools. The goal is to advance in the application and evaluation of equality measures in universities with the support of non-university entities that favor their promotion, impulse, evaluation and development. The GEPs will pursue the recognition and promotion of the research career of women, the incorporation of women in decision-making positions, and the promotion of a culture of equality in organizations. To this end, the focus will be on the deconstruction of sexual roles in order to unveil often unconscious gender biases that operate in processes of decision-making, selection and promotion of people and in the attribution of value and recognition.


**Keywords:** Gender Equality Plans, effective equality, structural change
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Performance assessment methodologies in application to guide the development of the safety case' (PAMINA) targeting Sixth Framework.

assistant: **Abstract**

The main objective of IP PAMINA is to improve and harmonise integrated performance assessment (PA) methodologies and tools for various disposal concepts of long-lived radioactive waste and spent nuclear fuel in different deep geological environments. The IP PAMINA aims at providing a sound methodological and scientific basis for demonstrating the safety of deep geological disposal of such wastes, that will be of value to all national radioactive waste management programmes, regardless of waste type, repository design, and stage, that has been reached in PA and safety case development. The work is organised in a small number of RTDCs. A comprehensive overview of PA methodologies, tools and experiences will help to develop a common understanding which includes terminology, accounted features and processes as well as codes and models used. From this methodological advancements will be investigated, evaluated or developed, including a framework for treating and managing uncertainty during PA and safety case development, various aspects of scenario developments for different host rocks, improvements of methods and tools regarding process understanding and conceptualization, the use of indicators for assessing the repository system or subsystems at various timescales, and the needs for implementing more sophisticated modelling approaches in PA. A handbook describing the state of the art of safety assessment methods will be prepared which includes the experiences of organisations directly involved in preparing safety assessments as well as of regulators and other organisations using such results. The consortium consists of 26 members from all major radwaste producing countries in the EU and Switzerland. From their different roles within their national programmes these members
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Controlling Large Language Models' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Large language models (LMs) are quickly becoming the backbone of many artificial intelligence (AI) systems, achieving state-of-the-art results in many tasks and application domains. Despite the rapid progress in the field, AI systems suffer from multiple flaws inherited from the underlying LMs: biased behavior, out-of-date information, confabulations, flawed reasoning, and more.If we wish to control these systems, we must first understand how they work, and develop mechanisms to intervene, update, and repair them. However, the black-box nature of LMs makes them largely inaccessible to such interventions. In this proposal, our overarching goal is to: *Develop a framework for elucidating the internal mechanisms in LMs and for controlling their behavior in an efficient, interpretable, and safe manner.* To achieve this goal, we will work through four objectives. First, we will dissect the internal mechanisms of information storage and recall in LMs, and develop ways to update and repair such information. Second, we will illuminate the mechanisms of higher-level capabilities of LMS to perform reasoning and simulations. We will also repair problems stemming from alignment steps. Third, we will investigate how training processes of LMs affect their emergent mechanisms and develop methods for fine-grained control over the training process. Finally, we will establish a standard benchmark for mechanistic interpretability of LMs to consolidate disparate efforts in the community. Taken as a whole, we expect the proposed research to empower different stakeholders and ensure a safe, beneficial, and responsible adoption of LMs in AI technologies by our society.


**Keywords:** Language models, Interpretability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AI Powered human-centred Robot Interactions for Smart Manufacturing' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

AI-PRISM is an industrial-end-user driven project that will provide a human-centred AI-based solutions ecosystem targeted to manufacturing scenarios with tasks difficult to automate and where speed and versatility are essential. The result will be an integrated and scalable ecosystem with installation-specific solutions for semi-automated and collaborative manufacturing in flexible production processes and for which specific robotic programming skills will not be required, thanks to its programming-by-demonstration modules. The ecosystem will be composed by four main pillars including 1) Human Centred Collaborative Robotic Platform, 2) Human Robot Cooperation Ambient, 3) Social Human-Agent-Robots Teams Collaboration and 4) Open Access Network Portal. In order to facilitate the assessment of the performance, transferability, scalability and large-scale deployment of these solutions, the demonstrations will be conducted under real operational environments in four pilot involving key manufacturing sectors - Furniture (ES), Food/Beverage (GR), Built-in Appliances (TR) and Electronics (PL) -, plus one generic demonstration facility (AT).  The project is not just aiming at quantitative improvements in a specific sector, but to use technology innovation to support a change of paradigm where AI, robotics and Social Sciences and Humanities (SSH) integrated in the manufacturing domain for the improvement of flexible production processes, become a feasible and widespread alternative for European factories, especially SMEs. To achieve this, the project relies on a strong consortium of 25 partners from 12 countries including international cooperation with Korea. The consortium brings together all the actors of the Human Robot Collaboration (HRC) value chain including relevant compet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of new functionals in dft methods - theory and applications' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content The objectives of the project consist in methodological developments of new functionals in DFT methods and applications to complex systems. The theoretical aspects concerne with the analysis of the effective one-electron operator of DFT, the Khon-Sham local potential, in particular its exchange-correlation part. One can try to determine, from very accurate ab initio wavefunctions, the local quantities that feature in DFT, with the underlying idea that an analysis of these exact quantities will help to systematically achieve further improvement. The applications will be focused on complex chemical systems containing transition metal centres involved in catalytic processes and will cover organometallic functionalities and chemisorption of small molecules on metallic surfaces. Training content (objective, benefit and expected impact) The main objective of the proposal is to find new, improved energy functionals in order to contribute to the theoretical framework for the understanding and prediction of physical and chemical properties of isolated molecular systems, through their implementation in ADF (Amsterdam Density Functional) code. This objective has a high training content, which will be of great benefit for my research activity: infact, I expect to achieve a more complete insight into the methodology of DF theory and to become experienced in the implementation of algorithms in parallel versions of the programs. Links with industry / industrial relevance (22) The ADF code is now used at about 150 academic sites and 20 industrial sites. The present project has therefore a large relevance on this respect.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integration of RNA Biology for Next-Generation Scientists' (INTEG-RNA).

assistant: **Concept**

While there are ever-increasing interconnections and integration across CEITEC MU research programs as well as across different scientific fields in nearby faculties, most of the research is still performed within the boundaries of individual laboratories or research programmes. The CEITEC groups involved in this proposal have diverse research interests however they are all connected by the same fiber- RNA. The overarching aim of this project proposal is integration of these groups at the level of methodological approaches, research questions and training of young scientists. In addition, empowering excellence in science and training, research management and boosting institutional recognition will position CEITEC MU as an RNA excellent research cluster. We plan to achieve our aims through close collaborations in joint research, increased mobility of researchers, ESRs and research management staff and increase the impact through dissemination of the results at a local, national and international level. The Twinning partnerships will help create a synergistic environment enabling CEITEC MU to have the confidence and expertise to establish an excellence RNA cluster with a Europe-wide network and competitive technologies, while heading for the future of excellence.


**Keywords:** RNA biology, bioinformatics, knowledge transfer, scientific mobility, cross-disciplinary collaboration, data analysis, ESR