RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Modelling of Epithelial-to-Mesenchymal Transition in Invading Cells' (METrIC), addressing dissemination and exploitation.

assistant: **Impact**

Cell migration is at the core of many biological processes in development and cancer progression. Epithelial-to-mesenchymal transition (EMT), i.e. the temporary and reversible switching between epithelial and mesenchymal phenotypes, plays a crucial role in increasing the motility and invasiveness of cells, representing a potential therapeutic target in many biomedical areas. With the surge of omics data, we are now more than ever able to characterise the phenotypic properties of cells and require theoretical frameworks which can effectively integrate such information to help us predict tissue-level behaviours for optimisation of therapeutic interventions.My project is devoted to the development of such a theoretical framework, in which cell migration through the extracellular matrix (ECM) is mediated by the cell phenotypic state which may change guided by mechanistic rules for EMT, incorporating information on the cell phenotypic state coming from omics data.I will focus on mathematical models comprising nonlocal partial differential equations of the evolutionary dynamics of space- and phenotype-structured cell populations. By representing cell phenotypes on a continuum, the models can capture intratumour heterogeneity and hybrid phenotypes, and may be directly linked with transcriptomic and proteomic data. This project will tackle the analytical and numerical challenges stemming from movement in physical space, modelling heterogeneous cell motion in the ECM, and complex phenotypic drifts, incorporating a description of core regulatory circuits for EMT, yet to be investigated in a unified framework. Moreover, we will address the inverse problem of employing transcriptomic data to infer the nonlinear impact of environmental factors on the core regulatory circuit mediatin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Solution-processed nanocrystal photovoltaics from environmentally benign and earth-abundant elements' (SUNLIGHT), addressing dissemination and exploitation.

assistant: **Impact**

In the search for cost-effective solar cells, colloidal inorganic semiconducting nanocrystals (NCs) have received much interest due to their readily-tunable absorption across the visible/near-IR, their high absorption coefficients and photostability. Yet many state-of-the-art NCs for photovoltaics are either based on toxic compositions or scarce elements on earth. It thus becomes essential to develop new systems from environmentally benign and earth-abundant elements with strong absorption properties. This project identified a few potential candidates, namely FeS2, Cu2S, CuO and Cu2ZnSnS4, due to their low raw material cost, their suitable band gaps, their high absorption coefficients and the availability of NC synthetic protocols. Relatively little work has been done on applying these NCs in solution-processed solar cells compared to those from II-VI/IV-VI groups, the Cu(InGa)(SeS)2 and Si systems. Specifically, this project involves the following aspects:1. Optimization of synthetic methods for the above-mentioned NC systems.2. Functionalization of NC surfaces with difference ligands via ligand exchange.3. Realization of field-effect transistors based on NC thin films and investigation of the effects of NC size/morphology and ligands on charge transport.4. Realization and optimization of solar cells based on NCs or NC/organic hybrids by correlating the effects of different synthetic and ligand conditions, improvement in light harvesting by the tandem cell approach.It can be anticipated that, by developing solar cells based on these new NCs, this project will gain fundamental understandings on how different NC and surface properties can impact the charge dissociation, transport, and recombination processes. The Marie-Curie grant would also consolidate the current effor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of environmentally friendly photoactivatable compounds for treatment of microbially polluted water' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The main objectives are as follows:* To develop a pilot plan for the decontamination of microbially polluted water by a novel photochemical technique, which is based on the use of visible light (or even sunlight) and porphyrin-type photosensitizers, i.e. a technique requiring a simple and cheap technology and having a low environmental impact.* To identify porphyrin photosensitizers which exhibit an efficient and non-specific phototoxic action against a broad number of microbial species, including Gram-positive and -negative bacteria, yeasts and mycoplasma.* To identify an inert water-swollen matrix (e.g. resin or inorganic bead) to which the photosensitizer can be covalently coupled without impairment of its photobiological activity.* To define a protocol for the efficient photosensitizer inactivation of microbes in waters to be used for aquaculture and irrigation.Expected OutcomeThe final result should be the development and validation of a pilot plant for water photosterilization as well as the mise-au-point of optimal protocols for large scale decontamination of water from aquaculture systems.The project should identify combinations of photosensitizer-inert support systems which are not noxious for the environment and allow one to achieve an efficient control of the microbial population without causing the selection of photoresistant species.* Synthesis and photochemical/photobiological characterization of polymer- or inorganic bead-bound porphyrin photosensitizer.* Development of protocols for large-scale photoinactivation of bacteria and other microbial species.* Evaluation of the efficiency of a pilot plant for water decontamination, possibly in synergism with mechanical filtration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optimisation of treatment with off-patent antimicrobial agents of ventilator-associated pneumonia (VAP)' (VAP).

assistant: **Innovation**

Background. Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, and “old” drug, is now the antimicrobial with greatest in vitro activity against MDR-GNB. However, no randomized clinical trial with colistin has been carried out. Additional aspects of colistin are also not well known, such as the appearance of resistant strains or alterations in the intestinal microbiome during treatment. Furthermore, conventional microbiological techniques take 48 to 72 hours to identify pathogens and determine their susceptibility. This is too long if empiric treatment is inappropriate.Objetives. The overall goal is the optimisation of the treatment of VAP caused by MDR-GNB, by defining a gold standard empiric therapy and reducing the period of time needed for the determination of the etiology and susceptibility of pathogens.Methods. MagicBullet proposes a randomized, open label, multicenter, clinical trial to compare the safety and efficacy of colistin vs. meropenem, both combined with levofloxacin, for empirical treatment of VAP. The pharmacokinetic and pharmacodynamic characteristics of colistin will be determined. Evaluation of the impact of the both treatments in the intestinal microbiome of patients and in the Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrug-resistant gramnegative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-omic data driven drug discovery and indication prioritisation platform in oncology' to be submitted under Horizon Europe.

assistant: **Abstract**

With 20 % of patients responding to their treatment and 10M dying every year, cancer is a recognised societal challenge. While data-driven approaches can double the clinical trials success rate, the pharma industry lacks tools to leverage the large amount of data generated in their drug discovery processes.We are developing mCUBE, an AI-powered platform that scales precision oncology for drug discovery and repurposing. Best-in-class and user-centric platform, mCUBE encapsulates a cancer-agnostic clinical data harmonisation module with an integrative approach to multi-omic data analysis. As our solution increases in value and allows us to move up the value chain, our initial SaaS business model will progressively switch to a drug discovery model. With mCUBE, we will identify and validate new drug candidates to license IP assets to pharma companies. By 2025, we expect to sign a deal of €25M with a biopharma partner. We will disrupt he oncology market for the benefits of cancer patients.


**Keywords:** machine learning,personalised medicine,omic analysis,drug discovery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Excellence in combustion and heat technology research and application' (ECHTRA) targeting Sixth Framework.

assistant: **Abstract**

The research staff of the Department of Heat Technology of the Lodz University specializes in combustion of homogeneous swirling mixture and accompanying processes of heat transfer to the walls. Combustion in a swirling mixture has its important practical implications in different kinds of industrial burners and in some up-to-date combustion systems of spark ignition engines. The special subjects of interest are: 1) properties of flames propagating in a lean mixture (low pollution of NOX), 2) the mechanism of flame quenching under the action of highcentrifugal forces (flame quenching is potential source of pollution), 3) proper experimental measurements of related heat flux determined under unsteady conditions, 4) related numerical calculations of selected p roblems of heat transfer phenomena. To the best of our knowledge nobody is studying in detail the phenomena of flame propagation and extinction in a field of high centrifugal forces. The main objective of the proposal is to enhance all the elements of the described above research. In order to obtain visible quantitative and qualitative progress it is necessary to train researchers in more effective use of the existing in the Lodz laboratory PIV system (DANTEC), in more wide use of the visualization methods, in development of data acquisition systems, in more wide application of numerical calculation methods etc. Experienced researchers from some leading European research centres, during their visits to the Lodz laboratories, may train the local staff in expe rimental and numerical techniques in the process of the joint research work. Experienced researchers from the Lodz University sent to the selected European research laboratories are able to develop research capabilities in experimental techniques (e.g. PIV ) and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Absolute time scales and isotope studies for investigating events in Earth and human history'.

assistant: **Concept**

The main goal of the ATIS project is the transfer of knowledge which will result in increasing the research potential of our GADAM Centre and expertise in applying and interpreting results in the fields of radiocarbon and luminescence dating, isotopic studies by means of mass spectrometry and gamma and alpha spectrometry; techniques that find direct application in the fields of climate reconstructions, dating and characterising climatic events in Earth history, assessing human impact on the environment - fields of our laboratory's intensive activities for many years.The goals will be realised by means of visits of our experienced and more experienced researchers in leading laboratories in the listed fields in the European Community, as well as by accepting researchers in our Centre. The stays of our scientists in the chosen institutions will enable us to start or continue long-term collaboration; our scientists will have the chance to keep their knowledge at the state-of-art level and acquire new skills; through interaction with scientists in partner institutions new ideas and research directions are expected to spring up. Within the ATIS stipends our scientists will carry out research in partner laboratories supplementing the European Quaternary climate reconstructions. It is expected that a considerable number of joined publications will result from the project.On the other hand, researchers from abroad staying in our laboratory through their daily involvement in our laboratory's activities, partaking in our seminars, taking active role in our internet-based post-diploma course, and assisting supervising diploma and PhD students will be able to transfer their experience and have a direct positive impact on our Centre's activities. In ATIS, we hope to be able to apply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Assessing BRDF effects of sun-induced fluorescence for quantifying canopy-level photosynthetic efficiency'.

assistant: **Innovation**

Over the past few decades, Earth-observation systems for land applications focused on deriving the type and/or status of green vegetation. Despite the fact that several missions are already dedicated to global vegetation monitoring, the derived information is mostly related to the amount of vegetation and not to the actual photosynthetic activity. There is, however, one additional source of information about photosynthetic activity in the optical domain that has not yet been exploited by any satellite mission. This source of information is related to the emission of fluorescence from the chlorophyll of leaves assimilating carbon. Measuring fluorescence from space would provide a direct measurement of the dynamics and actual functioning of the photosynthetic machinery. Within ESA’s FLEX demonstration mission, the University of Valencia undertook the first steps to acquire fluorescence measurements at canopy level. We propose a working package (FluorBRDF) that enforces a more robust spatially-explicit retrieval of fluorescence. FluorBRDF aims to account for bidirectional reflectance distribution (BRDF) effects, which is not only a function of sun-sensor geometry but also of the anisotropic properties of vegetation cover. Assessing and correcting for BRDF effects as induced by variations in vegetation canopy heterogeneity may lead to a more reliable measures. Challenges related to BRDF effect affecting the fluorescence signal brings us to the following objectives: i) to gain insights in the BRDF effects of the canopy-level emitted fluorescence signal on a theoretical basis using radiative transfer models, ii) to develop a methodology to correct for it. And finally, iii) to achieve higher accuracies of airborne fluorescence measures of heterogeneous canopies. This work will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Vortex enhanced liquid chromatography for HbA1c monitoring based diabetes management in a globalized setting' (VortexLC).

assistant: **Innovation**

Diabetes is one of the main health risks today with near pandemic dimension, causing blindness, kidney failures, stroke, heart attack, giving rise to very high health care costs (25% in the US) and reducing the quality of life of around 500 million people worldwide. The level of hemoglobin A1c (HbA1c) is used to assess long-term glycemic control and is the best predictor for the risk of developing chronic complication of diabetes and appropriate follow up of the patients. The golden standard is an expert laboratory HPLC method focusing on HbA1c quantification, which has limitations when other relevant hemoglobin variants are to be detected. For approximately 7 % of the worlds population which are carriers of such hemoglobin variants current methods lead to under-, over- or non-estimation of the HbA1c fraction. VortexLC will not only improve the quality of the analysis to give an instant full picture of the health status of diabetes patients, it will also produce a cheap point of care device. The use of  vortex flows renders the approach compatible with mass manufacturing of plastic pillar array columns, that are not only much cheaper than commonly used packed bed columns, but wherein also higher separation performances can be obtained. The polymer columns will be fabricated using UV-nanoimprint lithography, plasma technology to make them porous and add a chromatographic coating, and lamination to close the column, all processes that can be scaled to roll-to-roll industrial manufacturing. The columns will be embedded in an instrument that allows for integrated sample preparation and miniaturized UV absorption and SERS detection, allowing for both quantification and identification of analytes. In the project a low footprint demonstrator of the novel system and columns wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INPUTS OUTPUTS VIRTUAL INTEROPERABLE SIMULATION  TEST OF AVIONICS SYSTEMS IN VIRTUAL/HYBRID/REAL TESTBENCH' (2014-2020).

assistant: **Innovation**

The aim of IOVISTAS VIRTEST project is to contribute to achieve the major expectations from More Electric Aircraft and consequently for reducing fuel consumption, by developing an innovative virtual testing methodology for on ground test facilities dedicated to High Voltage direct Current integration. The project will allow avoiding difficulties related to physical test benches used in aircraft development process, which are complex platforms with high initial and recurring costs. They are usually on the critical path on the development and cannot be easily multiplied to increase the validation capacity.In particular, the facilities and equipment proposed will be used to test on ground actuation systems of electromechanical actuated surfaces such as ailerons, flaps, spoiler and winglet proposed by the Topic Manager in the context of Clean Sky 2 Regional FTB2 demonstrator, following the technology validation process before the aircraft integration.In this context the general objective of IOVISTAS VIRTEST project is the design, development and installation of a configurable virtual/hybrid/real ground test environment, aircraft and airframe representative, according to VISTAS EUROCAE standard for on-ground tested validation (up TRL5 of technology integration of airframe) of flight control surfaces driven by electromechanical actuators powered by high voltage DC electrical generation (HVDC).This general objective is twofold:•To develop an A/C representative electrical test installation composed by the HVDC part of the A/C electrical generation and distribution system. •To develop the I/O box concept, in accordance with VISTAS protocol, in order to provide the necessary interconnection between real and virtual test environments, and providing the necessary infrastructure for