RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The nanomechanical mechanism of exocytotic fusion pore formation' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Cells release neurotransmitters, hormones and other compounds stored in secretory vesicles by a process called exocytosis. In this process, the molecules are released upon stimulation by a nanomachine forming a fusion pore that connects the vesicular lumen to the extracellular space. Similar fusion events are also essential for intracellular transport mechanisms and virus-induced fusion.Here I propose a multidisciplinary approach using highly innovative techniques to determine the nanomechanical mechanism of fusion pore formation. The proposal is based on the hypothesis that the vesicle fusion nanomachine is formed by the mechanical interactions of the SNARE proteins synaptobrevin, syntaxin, and SNAP-25 and that the fusion pore is opened by intra-membrane movement of the transmembrane domains. I will combine fluorescence resonance energy transfer microscopy with detection of individual fusion events using microfabricated electrochemical detector arrays to demonstrate that fusion pore formation is produced directly by a conformational change in the SNARE complex. I will estimate the energies that are needed to pull the synaptobrevin C terminus into the hydrophobic membrane core and the forces that are generated by the SNARE complex for wild type and a set of specific mutations using molecular dynamics simulations. I will determine how these energies and forces relate to inhibition and facilitation of experimentally observed fusion, performing patch clamp capacitance measurements of vesicle fusion in chromaffin cells expressing wild type and mutated SNARE proteins. Based on these results I will develop a detailed picture of the molecular steps, the energies, and the forces exerted by the molecular nanomachine of fusion pore formation and will ultimately generate a molecul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European guideline for healthy high fibre/ low salt baking process based on the use of European barley' (2002-2006).

assistant: **Innovation**

The increased use of vegetable proteins for animal feed has led to a significant increase in import of soybeans from South America, United States and Asia, mainly because vegetable proteins from soybeans are better suited for animal then vegetable proteins from barley which has been the traditional source in Europe. This rapid decline in demand for Barley caused by increasing soybean imports has had a significant impact on the future sustainability of barley farmers in Europe, most of which are SMEs.To survive, barley farmers must seek new applications for their barley in European food products. Currently there are about 5.4M farms in the EU with an estimated turnover of 312 Bn employing over 10M people. Within the farming sector 22% of those employed are associated with the production of barely. Barley is a major European cereal product. This Collective project aims to create a deeper connection between the barley farmers and the supply chain above them, in order to provide new technology and knowledge to the 11,000 SME millers and 85,000 SME bakeries to enable them to significantly increase their use of (and thus stimulate consumer demand for) barley in producing the largest single food product in Europe - bread".We believe that through the transfer of new enabling knowledge and baking know-how, the use of barley as a substitute for wheat can be significantly increased and lead to the production of a tasty alternative that has the potential to be much lower in salt content - the main contributing to cardio vascular disease. Whilst wheat production in Europe is not well differentiated globally and there are high levels of imports at around 27.9M tons per year. Barley production however is a major European strength due to the climate and growing conditions included with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'RAILWAY DIGITALISATION USING DRONES'.

assistant: **Objectives**

The objective of the RADIUS proposal is to develop a drone – based technology to:(1)Monitor the physical status and electronic functionality of both non safety – critical and safety - critical railway signalling assets(2)Execute specific maintenance activities.RADIUS will focus on:(1)The identification of the best drone technology to be used in the railway sector, considering mainly the signalling assets to be monitored, the characteristics of the lines, the maintenance actions to be implemented and the distances to be covered(2)The design a/o the utilization of drone solution and related payloads capabilities to integrate:a.Sensors, data collection and processing capabilities to allow the monitoring of signalling assetsb.Wireless technology to be used to provide a secure communication channel between the drone and the peripheral device, and to allow contactless diagnostic and SW maintenancec.Use of EGNSS solutions for navigation and positioning, such as GALILEO and EGNOS (SBAS), enabling improved drone flight control and safe movements in the complex railways operational scenariod.The most secure data transmission solution to guarantee reliable and secure data exchanges, and embedded data analytics to perform assets monitoring, maintenance prediction analysis, and repairing actions avoiding railway track possession(3)The adaptation a/o redesign of the railway signalling assets to become drone – friendly for the maintenance activities, including the design of a docking station(4)The interaction with existing Intelligent Asset Management Systems(5)The interaction with current Traffic Management Systems, to improve the safe movements of drones within the railway(6)The planning of drone mission strategies in compliance with applicable regulations and with the complexity of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'End-User DevelopmENT - Empowering people to flexibly employ advanced information and communication technology' under Fifth Framework.

assistant: **Concept**

The main purpose of the network of excellence is to help the European Commission to prepare a research agenda in the end-user development field for the next framework and to increase contacts among highly-qualified research centres, both academic and industrial, in order to ease exchange of information and results and speed-up the production of innovative ideas and approaches in the field considered. The domain of the foreseen activities lies in the intersection between human-computer interaction and software engineering. Usability will be a main concern at all levels of the process, while still requiring the design of approaches able to produce consistent and systematic solutions for the envisioned interactive environments.Objectives:During the lifetime of this network we plan to consolidate and to build on that we have achieved to date. We aim at promoting End-user development principles and practices through a mix of outreach activities, which include workshops and participation in major international meetings. Further, having established a Europe-wide community of research groups in end-user development, we aim at defining the shared vision of the future of RTD in this research area. A shared vision will provide a focus for European RTD highlighting our strengths and leading to a current presentation of European work in the global marketplace.Work description:The network will balance development of research ideas with industrial collaborations and dissemination of results. To achieve this the workprogramme is organized into five work packages (research coordination, industrial cooperation, information dissemination, evaluation, management and administration). The type of approaches that we plan to consider include adaptable and adaptive systems, tailoring of system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New materials for technologies for flat panel displays' (FLATNET).

assistant: **Concept**

The annual worldwide revenue of the flat panel display industry is predicted to exceed $23 billion by 2003, up from $13 billion in 1997. In particular, revenue from high-end applications such as portable and desktop computers, and television will account for greater than 75% of the total. The industry is dominated by Far East manufacturers. Japan is especially strong with South Korea and Taiwan making substantial inroads in high value market segments. While member States of the European Union have worldclass scientific activities in relevant fields (indeed many of the inventions which underpin the existing industry have their origins in Europe) our production capacity is only a few percent of the worldwide total. The active matrix liquid crystal display (AMLCD) is currently the market leader for high information content displays. Its shortcomings, which are exacerbated as the display size increases, has encouraged global research on alternatives and improvements. A number of European Union R&TD programmes (particularly in Brite-Euram and ESPRIT) aim at developing materials and production technologies to meet this challenge.These include research on the well-established plasma, ferroelectric liquid crystal, and inorganic electroluminescence technologies; enhancements to current AMLCDs; and development of emerging technologies with outstanding potential such as field emission and organic electroluminescence. Opportunities also exist for low information content applications and EU programmes on, for example, light emitting diodes and alternative liquid crystal effects address these areas. This Thematic Network will bring together currently dispersed industrial and academic groups working on display technologies within the EU with the broad goal of ensuring that Europe resp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Stress Technology X-Ray Industrial Analyser' to be submitted under Fourth Framework.

assistant: **Abstract**

The proposed research project aims to design and create a miniature X-ray diffraction device so as to measure residual stresses in materials. This device will be portable and suitable for industrial exploitation conditions. Research is required : - to improve the performance of the existing technologies (interms of rapidity, resolution, repeatability and reproductibility), - to allow the development of a miniaturised device, which will achieve measurementswhatever the geometry and size of the mechanical controlled parts. The projectwill take into account some of the application conditions for each industrialsector of users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'TOLWEC: Fault diagnosis and fault-tolerant control for reliable wave energy converters' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The EU aims to raise the European share of renewables from 23% in 2023 to 42.5% by 2030. Such a goal implies obtaining clean energy from diverse sources. Although sea waves can provide a massive contribution in this sense, the commercial use and development of wave energy converters (WECs) are still very limited. This fact has been attributed to expensive production, installation, and maintenance, caused by the hostility of the sea environment and the corrosive nature of seawater.  To achieve an appropriate balance between reliable performance and economic costs of WECs, the main objective of the TOLWEC project is to build a framework for fault diagnosis (FD) and fault-tolerant control (FTC) based on a multilevel scheme, composed of local fault handling (i.e., FD and FTC) of each subsystem of the WEC, coordinated by a higher-level fault handling for the whole WEC. The main subsystems of a WEC are (i) a primary converter (PC) that captures mechanical energy from the waves, (ii) a power take-off (PTO) that converts mechanical energy into “raw” electric energy, and (iii) an electric power converter (EPC) that makes electric energy fit for consumption. Each subsystem has sensors and actuators for the diagnosis and control tasks. The sensors measure dynamic variables of the system, while the actuators allow one to shape the behavior of the system.The proposed research requires obtaining high-fidelity models of each subsystem, modelling possible faults, assessing the availability and cost of sensors and actuators, and designing the local and global FD and FTC schemes.As a result, the proposal will increase the economic viability of WECs by (i) reducing operational costs with accurate and early FD to avoid expensive repairs, (ii) preserving the energy conversion in the presenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Focused ultrasound and microbubbles targeting alpha-synuclein pathology-related dementia (FUMA)' to be submitted under Horizon Europe.

assistant: **Abstract**

Over half of Parkinson Disease patients develop cortical dysfunctions leading to Parkinson Disease Dementia (PDD). The cognitive changes are primarily driven by pathological alpha-synuclein (a-syn) protein aggregates with secondary synaptic dysfunctions in the cortex. Microglia plays a key role in synapse maintenance and clearance of aggregated a-syn proteins, however, this is impaired in PD. Low intensity focused ultrasound (FUS) combined with intravenous microbubbles (MB) can non-invasively increase the permeability of the blood-brain barrier, resulting in a transient and controlled entry of blood-born substances. In animal models of Alzheimer disease, FUS-MB treatments increase microglial-mediated clearance of extra- and intracellular protein aggregates and improve synapse health. In small patient cohorts in the clinic, FUS-MB treatments are safe and results suggest decreased levels of pathological proteins in Alzheimer disease patients. HYPOTHESIS: FUS-MB applications targeted to the cortex promote cortical a-syn clearance and synapse maintenance which can prevent or slow the development of dementia in PD.In a mouse model of PDD we will determine the ability of FUS-MB treatment to increase microglial-mediated clearance of a-syn, maintain synapse health, and inhibit the development of cognitive dysfunctions. In addition, we aim to evaluate non-invasive positron emission tomography and magnetic resonance imaging as biomarkers of the effects of FUS-MB treatment. Finally, we will investigate the underlying pathway of potentially beneficial effects of FUS-MB treatments by measuring changes in specific pathways of interest as well as perform an unbiased screen for novel targets.Both the researcher and supervisor have a background in Parkinson disease research. The researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stratospheric Dynamics for Seasonal Prediction' in the context of a Horizon Europe call.

assistant: **Objectives**

Seasonal forecasting is a field with enormous potential influence in different socio-economic sectors, such as water resources, agriculture, health, and energy. Yet, surface climate conditions in Europe still represent a hurdle to formulate skillful seasonal predictions. SD4SP aims to improve simulation and prediction of the remote influence of two dominant tropical variability modes in the North Atlantic-European (NAE) region: El Niño-Southern Oscillation (ENSO), and the Quasi-Biennial Oscillation (QBO); which are the leading modes of interannual variability in the tropical troposphere and stratosphere respectively. ENSO is highly predictable and constitutes the cornerstone of seasonal forecasting. The QBO is well constrained by initialization and has a long persistence, being considered as the most promising source of seasonal forecast quality with ENSO. However, many scientific questions remain unresolved concerning their tropical-extratropical teleconnections, and model systematic errors only worsen the problem. SD4SP will focus on the stratospheric pathway of the ENSO/QBO teleconnections to NAE and pursue gaining insight into the dynamical mechanisms at play. This goal will be undertaken by carrying out an unprecedented set of idealized seasonal forecast experiments to address the contribution of the tropical stratosphere and the polar stratosphere to the prediction skill by suppressing variability in the two stratospheric regions, separately. SD4SP is very timely in helping to reduce model biases and to increase current seasonal forecasting capabilities for the NAE surface climate. The goal of SD4SP is twofold: to identify key sources of predictability and to improve understanding and simulation of the mechanisms responsible for that predictability. SD4SP will bri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Recycling-oriented alloy design for next-generation of sustainable metallic materials' (ROAD-SiM).

assistant: **Concept**

European industry increasingly focusses on recycling, pushing towards circular economy as part of EU Green deal. This offers enormous energy savings and CO2 reductions. However, there are several problems hindering the metals recycling.Effective solution to counter these problems is the development of new alloys, recycling-friendly by design.One of the rising problems during recycling, is the progressive accumulation of impurities in alloys produced from scrapmetal. Elements such as tin cannot be effectively removed during manufacturing alloys from scrap. Therefore, the nextgeneration of alloys will have be able to tolerate more impurities (therefore inclusions) than current alloys. Such materialsalso have to be more resistant to fracture, due to the potential damage nucleation at inclusions. However, impurities causesignificant changes of properties and induce considerable complexity even in simple alloy systems. Therefore, thedevelopment of the recycling-oriented alloys based on understanding of changes caused by various compositionaldeviations require a significant volume of research.Concentrated solid solution alloys, including some of the established compositions of austenitic steels have the attributesessential for recycling-oriented alloys. They show enhanced tolerance to compositional deviations due to the extendedcompositional space with desired microstructures. and intrinsically high ductility levels.In this project, we first aim to analyze the consequences of the compositional changes and impurities to the changes ofmechanical properties and damage-tolerance of said materials. Ultimately, scrap-compatible alloys for sustainablemetallurgy will be prepared. Special attention will be placed on the effects of the elemental partitioning and their interactionswith