RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Handling with AI-enhanced Robotic Technologies for flexible manufactUring', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

HARTU will provide the necessary tools to implement three basic stages of parts handling, i.e., grasping, assembly and releasing. These tools aim to address the key challenges for creating handling applications by means of innovative technical approaches: (1) self-supervised grasp and release planning policies identification and control; (2) to learn and control contact-rich assembly skills from human demonstrations; (3) to develop an AI-based multi-modal perception for visual-servoing and continuous monitoring in handling operations, supported by virtual and continuous learning; and (4) to develop versatile and dexterous soft grippers with electro-active fingertips. HARTU is an industry-driven research project that includes the deployment of technologies in 5 industrially relevant scenarios: 4 manufacturing lines in different sectors: automotive, household appliances, hand tool manufacturing and food processing, and 1 in logistics to validate that the technologies can be transferred to other sectors. They offer an enormous variability of products in terms of shape, material and sizes. This approach contributes to the (1) industrial objective of HARTU, i.e., to increase the flexibility, reconfigurability and efficiency of manufacturing lines through easy to integrate and configure, safe and reliable handling systems, supported by tools for application development and a reference architecture. It also contributes to the (2) social objective: to contribute to user acceptance and adoption, identification of skills development needs and compliance with the liability/legal and ethic aspects.


**Keywords:** Grasping, Assembly, Planning, Electroadhesion Gripper, Perception
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multidrug-resistant and hypervirulent tuberculosis: integral approach to rapid detection and evolution', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Multidrug-resistant (MDR) and hyper-virulent (HV) Mycobacterium tuberculosis (MTB) strains increasingly circulate worldwide and start to threat European and global health security. Rapid detection of these hazardous MTB variants presents the first step in fighting TB and is vital for both patient and community health. We propose a novel integral approach to tackle modern TB. We propose to develop a three-step strategy based on use of sensitive molecular techniques and including simultaneous (1) diagnosis of TB (2) detection of drug-resistant, and (3) hyper-virulent MTB strains.The obtained information will be used for timely prevention of TB including early diagnosis and adequate treatment of TB patients and prognosis of the eventual emergence of new hazardous strains in future. Understanding genetic basis of virulence in circulating strains will contribute to development of a new generation vaccine efficient against modern TB. Additionally, the project will further develop a novel basic concept proposed by th e Applicant about human/microbial co-evolution.The generated data with be compared with unique global databases at the Host laboratory in order:(1) to reconstruct global phylogeny of M. tuberculosis,(2) to better understand evolution and emergence of hyper-virulent M. tuberculosis,(3) to develop a quantitative approach to comparative analysis of human and microbial diversities and co-evolution that may be extended to other pathogens.A large MTB collection is already available at Host and Applicant's laboratories for this project that will bring together intellectual efforts and ideas of the Applicant with technical capacity and expertise of the Host. This project will be an excellent example of synergy in applied and basic research in Genomics for Health and Healt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reshaping undesired Inflammation in challenged Tissue Homeostasis by Next-Generation regulatory T cell (Treg) Approaches – from Advanced Technology Developments to First-in-Human Trials' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to reshape undesired intra-tissue immune imbalance in immune-related disease entities. It supports long-term function of allografts and use of Advanced Therapy Medicinal Products (ATMP) by overcoming the challenge of unwanted immune reaction by the recipient of the ATMP. Therefore, adoptive Treg therapy is a potential game changer in health care, particularly in immune diseases, organ & hematopoietic stem cell (HSC) transplantation, and regenerative medicine, including gene therapy.Based on the Triple-T concept - Transdisciplinarity, Technology, Translation - the major goal of RESHAPE is to transform the treatment of patients suffering from undesired immunity/inflammation, who presently have limited curative treatment options, by applying novel Treg approaches that overcome the limitations of 1st generation Treg product developments.Members of the consortium, with academic & biotech backgrounds, are pioneers in the development of Treg therapy from basic science to very recent encouraging First-In-Human (FIH) clinical trials of  the 1st generation Treg products. They have a longtrack record of collaboration, including in EC-funded projects. The first clinical trials were performed to combat organ transplant rejection and Graft-versus-Host-Disease. However, promising preclinical studies offer a broad application field of Treg therapy beyond allotransplantation. Based on our preclinical & clinical data, we have identified several opportunities for improving Treg therapy, such as enhanced antigen specificity & functional stability, and recipient conditioning, that will be addressed by RESHAPE. The next-generation Treg products, developed by advanced technologies including CRISPR/Cas9, will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and testing of new standards for sorption measurement and characterisation of ionic liquids (S-SCIL)' (S-SCIL), addressing dissemination and exploitation.

assistant: **Impact**

The aim of S-SCIL is the development and testing of new standards to measure the selective sorption for multigas application. This technology, which is not yet available, brings huge advantages for various kinds of chemical, pharmaceutical, environmental, food and energy processing. These new standards can be used to characterise the substances which are used to perform the process (porous solids, (nano- )particles, polymers, liquids) concerning their selective behaviour in gas-mixtures as well as to invest igate the process itself in terms of temperature, pressure and composition. In addition, the main single gas sorption measuring standards, including the multi gas ones developed by this project, will be investigated and adapted for the characterisation and investigation of pure and multigas processing based on ionic liquids. Targets are: investigation of several methods for gas analysis concerning their potential for combined sorption measurements in a wide range of temperature and pressure; development of a simple and economic sensor combination for a wide range of temperature and pressure; combination of gas analysis modules with two high end sorption measuring apparatus, one combined gravimetric / volumetric for measurements in static atmospheres and one gravimetric for measurements in a forced flow through; design and manufacture of a prototype of a commercial instrument based on the development previously done; adaptation and testing of sorption measuring standards, including the new ones to characteriz e ionic liquids and investigate chemical processing realized by using ionic liquids.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural Studies of the Human Cytomegalovirus Glycoprotein B Activation Mechanism of PDGFR alpha' to be submitted under Seventh Framework.

assistant: **Abstract**

HCMV infection is life-threatening for immuno-compromised patients, and is the most frequent cause of congenital abnormalities in Europe and the USA. HCMV infection can also lead to cardiovascular and chronic bowel inflammatory diseases and several types of cancer (the latter is still a matter of controversy). Effective treatment for HCMV disease is available, but the rapid emergence of drug resistant strains pose an urgent need to find new targets and to develop new inhibitors against HCMV. For cell invasion, and in order to carry out different parts of its life cycle, the HCMV directly manipulates normal cell signaling pathways. The HCMV envelope glycoprotein B (gB) has a versatile role in this process: first, it attaches to the host extracellular matrix - thus participating in viral absorption. Next, gB specifically binds to and activates a cell surface receptor – the Platelet Derived Growth Factor Receptor  (PDGFR) which initiates a cell-survival response, followed by a gB-mediated membrane fusion. Anti-gB neutralizing antibodies are developed, aiming to prevent HCMV infection and disease. The ultimate goal of this research is to understand the structural basis of PDGFR activation by HCMV gB. Using X-ray Crystallography and Electron Microscopy, two of the most powerful techniques in current structural biology, we specifically aim to: 1. Understand how the binding of HCMV gB results with PDGFR activation and cell signaling events. 2. Chart the gB-PDGFR interacting surfaces and define the most critical determinants in this interaction. Taken together, the expected results will shed light on a vital element in HCMV invasion and will set the ground for the design of specific inhibitors to treat HCMV infection and disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Focus on Advancing Spatial and Temporal Resolution of 3D Structured Illumination Microscopy' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

FASTR 3D SIM: Focus on Advancing the Spatial and Temporal Resolution of 3D Structured Illumination MicroscopySuper-resolved structured illumination microscopy (SR-SIM) is an important method to surpass the resolution limit in fluorescence microscopy. SR-SIM is compatible with many fluorescent labels and ensures low photo-damage, making it an ideal candidate for live-cell imaging. However, to be truly applicable, very fast 3D imaging has to be realized, as the cellular structuring is 3D in nature and fast dynamics have to be captured. In addition, many biological processes occur at length scales below 100nm, beyond SR-SIMs two-fold resolution improvement.I will develop an advanced 3D SR-SIM microscope able to capture 3D images at video rate, i.e., 25 3D images per second, 10 times quicker  than the fastest currently available systems. The extreme speed-up is achieved by a unique multi-focal optics approach available at the host institute, and will also reduce the photo-toxicity to the sample. My  SIM reconstruction code (www.fairsim.org) will be extended to 3D imaging, and include new algorithms tackling low light levels and strong out-of-focus light.I will also develop a revolutionary combination of SIM with super-resolution optical fluctuation imaging (SOFI), a specialty of the Dedecker lab. SOFI is employed to create non-linear effects, allowing SIM to surpass its 2x resolution enhancement. This enables rapid and repeatable 3D imaging of cells with a spatial resolution approx. 60 nm in x,y and 150 nm in z.I will apply the tools to an acute biological question, the dynamics of mitochondrial and ER interactions, used by the cell as signaling scaffolding points. Here both the temporal and spatial resolution of the proposed system is required to observe the very fast dyna
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photoinduced ultrafast carriers and thermal effects within metasurfaces for light-driven catalysis' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Chemical transformations involve formation and breaking of bonds in molecules, and their rate is determined by the reaction pathway for converting reactants to products. The use of photoexcited plasmonic nanostructures to alter such pathways, hence improving the reaction economics, has recently emerged as a transformative solution to the extreme energy demands of traditional catalysis. Strong photothermal nanoheating and high-energy charge carriers can be optically induced in metal nanoparticles, creating a local environment where reactions occur at temperatures far below those of common catalysts and lowered energy barriers. Most plasmonic photocatalysts operate however in the steady state, which intrinsically restricts rates and photon usage, as the inherent dynamics of chemical bonds, catalyst surface, and light-matter interactions remain untapped. This project aims at introducing new theoretical approaches breaking the steady-state paradigm to drive reactions along thermal and nonthermal pathways with ultrashort pulses. A comprehensive numerical model will be developed to rationalise the dynamics at play and design metasurfaces (ordered nanostructure arrays) working as photocatalysts in the ultrafast regime. Pulsed (femto- to nanosecond) light will be used to induce transient localised heating and to enhance the photogeneration of hot carriers on timescales relevant to the chemical kinetics. The two effects will contribute to promote reactions with increased energy efficiencies: the intrinsic thermal nonlinearities of chemical processes will be leveraged to achieve rates out of reach in steady state, the dynamics of high-energy carriers will be tailored to unlock nonthermal channels with selectivity otherwise unattainable. The envisaged predictive time-resolved mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Coping with the complexity of business innovation'.

assistant: **Objectives**

HARMONY pursues the vision of a significant increase of success chances of start-up intentions and innovative SMEs. The target group encompasses every party involved in the start-up support process, such as start-up coaches, centres of innovation and technology, investors, business angels, and the entrepreneurs themselves. Focus is the enhancement of quality of the support process as well as improved communications between the parties.In spite of numerous national and private initiatives there is still a huge demand for extensive support for the initial stages of a business foundation. This is particularly true for the methodological area, for the co-operation of various parties, and particularly with regards to suitable, pragmatic tools.  Support organisations in the field of business start-up nowadays are still missing a recognised quality standard; often the support process takes place with strong insufficiencies in efficiency and global networking. This usually means additional time exposure on the account of the start-up entrepreneur. The HARMONY network formation, internet based knowledge management, and an adaptable, process oriented reference methodology have the aim to improve the quality and efficiency of start-up support. From several IMS regions expertise and practical experience is flowing into the project. At regular intervals open national HARMONY circles of experts" are being arranged. The methodology is being realised on the basis of the HARMONY software family, consisting of the entrance portal (Entrance Tool), the internet based knowledge- and project management system (KBT - Knowledge Base Tool), and the multimedia business plan writer (Innovation Project Configurator), together with the training modules and the possibility of an academic online qual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Epidemiology and function of the variant esp gene in enterococcus faecium' under Fifth Framework.

assistant: **Concept**

A strong association between the presence of the variant esp. gene in vancomycin- resistant Enterococcus francium and in-hospital spread of these bacteria is recently described. We want to investigate the epidemiology and mechanisms of the esp. gene and its potential role in the pathogenesis of enterococcal diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Terabit Optical Processing using Comb Locked Amplified Signal Synthesis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

All-optical signal processing promises a route to unprecedented processing bandwidths - orders of magnitude greater than possible using electronics. Ultrafast optical processing offers the potential to revolutionise many existing fields of photonic applications including telecommunications, metrology, and optical sensing. It also promises to be a critical technology for other emerging disciplines including environmental science, biology, medicine and security. However, its application has been hindered by the lack of a number of critical components – in particular the availability of a high-power, low-noise, truly-broadband, optical signal synthesizer/arbitrary waveform generator operable up to the multi-THz regime. To develop such a device requires full control over the amplitude and phase of large-bandwidth high repetition rate optical signals which has been a challenge to date. Here, we propose to investigate one possible approach to realise a high performance, optical signal synthesizer based on the coherent superposition of multiple, phase locked lasers operating at spectrally-distant optical frequencies (e.g. on a 1 THz grid to allow THz pulse train generation). To achieve the high level of coherence among these lasers we propose to phase lock them to a high-quality optical ‘ruler’ (optical comb). This approach brings several important advantages over the direct use of line-filtered optical combs - the only other real alternative approach to date. These include: (i) a much larger line spacing (e.g. >1 THz, as opposed to 250 MHz – 10 GHz for conventional combs); (ii) far higher powers-per line (e.g. 50 mW, as opposed to ~1 µW for a typical comb) and; (iii) reduced demands on the associated filters and combiners. We propose to demonstrate the advantages and potentia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Complexity of Dynamic Matrix Problems' under Horizon Europe.

assistant: **Concept**

Modern data analysis and optimization rely on our ability to process rapidly evolving dynamic datasets, often involving matrix operations in very high dimensions. Dynamic data structures enable fast information-retrieval on these huge databases by maintain- ing implicit information on the underlying data. As such, understanding the power and limitations of dynamic (matrix) data structures is a fundamental question in theory and practice. Despite decades of research, there are still very basic dynamic problems whose complexity is (exponen- tially) far from understood – Bridging this gap is one of the centerpieces of this proposal. The second theme of this proposal is advancing the nascent role of dynamic data structures in continuous optimization. For over a century, the traditional focus of optimization research was on minimizing the rate of convergence of local-search methods. The last ∼3 years have witnessed the dramatic potential of dynamic data structures in reducing the cost-per-iteration of (Newton type) optimization algorithms, proclaiming that the bottleneck to accelerating literally thousands of algorithms, is efficient maintenance of dynamic matrix functions. This new framework is only at its early stages, but already led to breakthroughs on decade-old problems in computer science. This proposal will substantially develop this interdisciplinary theory, and identifies the mathematical machinery which would lead to ultra-fast first and second-order convex optimization. In the non-convex setting, this proposal demonstrates the game-changing potential of dynamic data structures and algebraic sketching techniques in achieving scalable training and inference of deep neural networks, a major challenge of modern AI. Our program is based on a novel connection of Kernel