RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Magnetic coupling and spin-dependent electron transport in metal/semi-conductor hetero-structures' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The goal of this project is to investigate the transport and magnetotransport properties of small patterned metal/semiconductor junctions. The different steps of this work will be: - the fabrication of metal/semiconductor heterostructures on well appropriate substrates - the detailed structural and magnetic characterization of these heterostructures with in situ and ex situ analysis methods - the study of the spin-dependent electron transport through the semiconductor of patterned junctions of these heterostructures. Training content (objective, benefit and expected impact) The project will allow me to get training with modern experimental methods, in particular of | epitaxial growth of semiconductor material, scanning tunneling microscopy, transmission electron | microscopy and high sensitivity magnetometers. Equally important, I will acquire a knowledge in | semiconductor physics and technology and combine it with the physics of magnetic metals. Links with industry / industrial relevance (22) Industrial activities in the development of novel magnetic sensors and memories are currently restricted to spin valve and TMR junctions. This project will provide an alternative working principle which might become very important for the next generation of devices. For this reason an existing collaboration on magnetic metal-oxide tunnel junctions between the host laboratory and German industry will be extended to metal-semiconductor systems in the near future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Unlocking self-patterning competence to engineer 3D human spinal cord'.

assistant: **Objectives**

Organizers direct formation of the body, releasing morphogens to position tissues and organs. But what organizes the organizers? I aim to harness organizer formation to build self-patterning 3D human spinal cord in vitro.In developing spinal cord, the floorplate organizer secretes Sonic Hedgehog to direct ventral-dorsal patterning. Prof Tanaka (secondment) discovered how to recapitulate this in vitro: single mouse naïve pluripotent stem cells (PSCs) form neural tube organoids and an early pulse of retinoic acid prompts self-organization of floorplate that drives patterning as in vivo. However, attempts to form cognate human organoids have been unsuccessful. There is a restricted window of competence to initiate floorplate formation, which conventional primed human PSCs are unable to access. To overcome this, I will combine microenvironment bioengineering with new naïve human iPSCs (Prof Elvassore, host) to recapitulate and study human development from an earlier stage, gaining access to molecular events that may underpin later fate specification and tissue organization. By mechanistic analysis in mouse organoids, I will reveal how competence is instated, how it is closed, and how to prolong or re-instate competence de novo. This knowledge will guide me in unlocking the competent state for human PSCs in vitro, and has implications for activating spinal cord regeneration in vivo. By use of sophisticated engineering technologies pioneered in the Elvassore group, I will control the micro-environment to guide tissue growth and formation, mimicking natural physiology and ensuring reproducibility. By engineering 3D organized human spinal cord in vitro, this project will bridge basic knowledge of critical and inaccessible stages of human development with future biomedical appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'First-principles global MHD disc simulations: Defining planet-forming environments in early solar systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The aim of this ambitious research project is to produce the most realistic computer simulations of gaseous protoplanetary accretion discs to date, and thereby define in an assertive way the environment that shapes the assembly and early evolution of planetary systems.In their role as planet nurseries, protoplanetary discs are of key interest to planet formation theory. Their dynamical, radiative and thermodynamic properties critically define the environment for embedded solids: dust grains, pebbles and planetesimals. In short, the building blocks of planet formation. The discs’ dynamics and structure in turn depend critically on the influence of magnetic fields that couple to tenuously ionised and low-density regions. Being comparatively cold and dense, the ionisation state of the disc plasma is dominated by external far-UV, X-Ray, and cosmic-ray radiation, leading to a layered vertical structure – with turbulent, magnetised surface layers and a magnetically-decoupled midplane. This classic ‘dead-zone’ picture is now turned upside-down by previously ignored micro-physical effects. For instance, ambipolar diffusion is predicted to dominate in the tenuous hot corona of the disc. It is expected that parts of the disc will thus be stabilised and a magneto-centrifugal wind will be launched. This has so far only been studied in very simplified local models that are affected by fundamental limitations.Our understanding of the structure of protoplanetary discs is about to undergo a dramatic shift, and my proposed research is at the forefront of this development. My recent successful work at the interface between MHD dynamics and planet formation theory makes me ideally skilled to lead a research group in this endeavour and to communicate advancements to a wide audience of theo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hold it or let it go: a niche decision on cancer growth' (WHOLENICHE).

assistant: **Innovation**

The tumour microenvironment or niche is the vital non-cancerous compartment of the tumour structure. Thus, targeting its tissue-derived cells represents a promising avenue to better therapeutic interventions. However, knowledge about the tissue cells taking part of the tumour niche during early cancer development and later progression is lagging behind due to the difficulty of analysing and following early tissue changes in the surrounding of cancer cells in vivo. In our research proposal we will use a combination of original tools developed in the lab and state of the art technologies to overcome some of these constraints and expand our understanding of which cells in the niche support early cancer cell growth. We also aim to reveal their mechanism of action and identify approaches to block the niche supportive activity. Our five-year plan has three main objectives (I, II, III), which we will meet using two original strategies. With the first strategy we will visualize the early tumourigenic niche in vivo. This will allow us (I) to identify and characterize novel cellular components during dynamic niche evolution both in the context of metastatic colonization as well as during primary tumour onset. We will also use this original approach (II) to deepen our understanding of neutrophils in cancer, a particularly crucial emerging component of the cancer niche, whose role is still debated. After dissemination, cancer cells may encounter an unfavourable niche, failing to start colonization and remaining dormant within the tissue. However, the quiescent-permissive tissue can change, cancer cells reactivate and form metastases even a long period after tumour resection. Little is known about the changes in the niche of dormant cells capable of triggering their reactivation. Wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hla-e transgenic mice - an experimental model for the in vivo study of the functions of hla-e molecules' in the context of a Fourth Framework call.

assistant: **Objectives**

The objective of our project is to set up an experimental model allowing the in vivo study of the functions of HLA-E molecules. With this aim, we have produced eight HLA-E transgenic mouse lines. The research programme will study: (i) the expression of HLA-E molecules, (ii) their role as transplantation antigens (skin graft rejection, bone marrow transplantation and graft versus host reaction), (iii) their antigen presentation capacity, (iv) their immunogenicity for B and T cells, (v) their influence on tumor growth, i.e. their possible role in immunosurveillance. In addition, the model opens up the possibility to produce HLA-E specific monoclonal antibodies, an essential and still missing tool for the detection of these molecules.In summary, the results of these experiments should contribute to the elucidation of the physiological significance and the role in transplantation of the abundant family of human nonclassical class I molecules.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High-resolution Decryption of Left Atrial Haemodynamics in Atrial Fibrillation (HiDDyn-AF)' (HiDDyn-AF).

assistant: **Innovation**

Atrial fibrillation (AF) is characterized by disorganized atrial electrical activation leading to a rapid and irregular heart rate. Incidence rates are rising to epidemic levels with aging populations. AF disrupts left atrium (LA) fluid dynamics, increasing the risk of stroke and catheter ablation seeks to restore sinus rhythm. We aim to develop of personalised risk stratification in AF patients, begin to optimise ablation treatment and generate novel findings about the pathophysiology of AF. High-resolution Decryption of Left Atrial Haemodynamics in AF (HiDDyn-AF) adopts a cross-disciplinary approach to combine computational fluid dynamics (CFD), 4D flow MRI, late-gadolinium enhancement MRI and computed tomography to create a novel model of LA flow. This model will be applied to investigate AF patients pre- and post-ablation. Furthermore, LA flow will be compared with myocardial fibrosis and strain. Previously, LA flow has been modelled in small groups with idealised or patient-specific geometries. Some applied wall motion however none have been validated with 4D flow MRI as planned in HIDDyn-AF. The project will further extend the state-of-the-art by analysing many more cases than previous studies (N=50), to produce impactful results. The research questions are built on the complimentary experience of the host team, clinical collaborators, secondment team and the applicant. Accordingly, the objectives are to: develop a novel, high-resolution, validated model of LA flow (O1), define LA haemodynamics (vortices, WSS and turbulence) for AF (O2) and determine: the haemodynamic impact of ablation (O3), if haemodynamics predict recurrence of AF (<1 yr) (O4), if a relationship exists between LA myocardial fibrosis (O5), myocardial strain (O6) and haemodynamics. HiDDyn-AF cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Flat EnOcean Room Operating Panels' in the context of a Seventh Framework call.

assistant: **Objectives**

The FEROP project goals are the development and integration of innovative technologies to build a home automation system allowing to remotely control the EnOcean ecosystem. Its functions, in the home environment, consist in controlling heating and air conditioning, giving orders to set comfort point (such as temperature, air quality, presence, etc.), adjusting lighting, shutters and blinds, or/and monitoring all the top-mentioned parameters via a display device. The objective of FEROP is to reach energy efficiency targets by taking into account the behavior of end users. In the house environment as occupants can contribute to the enhancement of the energy saving. They could directly and easily interact with the building using remote, repositionable at will, and battery free panels. This project will be supported by a consortium composed of four SME (2 French, one Italian and one Portuguese) and two RTD Performers (France and Italy).The developed product will be a wireless battery-free touch panel display formed part of seven layers, each one presenting a single function (Photovoltaic, Capacitive touch screen, Bi stable low power flexible screen, Flexible PCB layer with EnOcean radio, Energy storage, Spacer and mechanical, Sticking).The challenges emphasized on this project are related to the product energy consumption (lower than possible) as well as the MMI (simple and intuitive). Eventually, the transparent solar film has to switch from laboratory to production in 2013.This innovative product, targets old buildings that have modernization needs by taking the advantage of tax incentives motivations, and also new buildings that allow the deployment of wireless technology and gateways, in order to manage and control the whole building energy consumption. The estimated ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Revising the Role of Groundwater in Life Cycle Assessment' in the context of a Seventh Framework call.

assistant: **Objectives**

Life Cycle Assessment (LCA) is the standardised method for assessing the environmental impacts of any product or service. After quantifying all associated emissions and the consumption of resources, this impact is expressed with respect to a few common impact categories. These are supposed to reflect major societal and environmental priorities. Although groundwater is the most extracted raw material in the world, and extraordinarily  important for most parts of the EU, it is virtually ignored in LCA. To overcome this deficiency, an interdisciplinary approach is needed. The proposed fellowship integrates a hydrogeologist into a prominent group of LCA experts, in order to develop the initial steps for tackling groundwater quality and quantity issues within an LCA framework. The fellow is offered extensive training on LCA concepts to combine the perspectives of both LCA expert and hydrogeologist. The research work includes a general gradation of threats to groundwater and the development of a competent modelling framework. The latter task is dedicated to the improvement and consistent development of modelling tools. This is to enable a balanced simulation of different hydrogeological threats, and to uniformly account for the spatial variability of environmental conditions. A major focus is placed on the issues of whether, and how, groundwater can be considered a safeguard object within impact assessment, assumed that it represents a separate receptor. The scientific results of this project are expected to be fundamental but still incomplete in achieving a generally valid methodology, which complies with the holistic requirements of LCA practice. However, it will be a necessary starting point for revealing the principal relationships between LCA and hydrogeology and ultimat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Galician Night of Researchers' in the context of a Horizon 2020 call.

assistant: **Objectives**

The emergence of the new coronavirus has meant a turning point, a radical change in many facets of our life and of course in the social perception of science and science communication too. During the crisis and for the first time in our era, a very large part of society really needed to rely and understand how science works and its outcomes, and they had to fight to find reliable and accurate sources of scientific information. The deafening noise of the first weeks was a sign that maybe scientist and their institutions have to communicate and listen better and that a closer relationship between science and society is still needed.In Spain, a survey carried out in April 2020 showed that healthcare professionals were the group that citizens rated most highly followed by scientists.In previous studies, such as Social Perception of Science 2018, it was already clear that the professions most highly valued by citizens were, in this order, doctors, scientists and teachers, over engineers, entrepreneurs, judges and journalists.Even so, a recent study certifies a 30% drop since 2000 in the number of enrolments in scientific and technical careers. It points out different causes for this drop and the main one seems to be the perception that it is not worth making the effort due to the imbalances in the job market.So, in this context, G-Night seeks to bring its research institutions to the whole population, to continue working and caring for a relationship that is strengthened every day. And for the first time, the main Galician centres and universities aim to do it together, reflecting the collaborative nature of science and knowledge generation. The Scientific Culture and Innovation Unit of UVIGO leads a project to bring together the 3 Galician universities, several research cen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Single-crystalline Lithium-based model systems of future materials for electrochemical energy storage and data storage' under Seventh Framework.

assistant: **Concept**

Li-based olivine phosphates exhibit an enormous potential for applications such as next-generation cathode materials for Lithium-ion batteries and for faster and more reliable data storage devices. A fundamental understanding of this extremely promising class of materials however demands single-crystals which allow to study intrinsic material properties and the interactions between intrinsic electronic and structural properties on the one hand and kinetics, domain effects and electrochemical performance on the other hand. The aim of the proposal is hence to synthesize and to investigate high quality single crystals of these materials for studying (1) anisotropic parameters relevant for applications in Lithium-ion batteries for different crystal directions, and (2) the ferrotoroidicity of the grown crystals for potential applications in data storage. In order to achieve this aim, a unique high-pressure traveling-solvent floating zone furnace will be applied which allows single crystal growth of Li-based systems under external pressure of 150 bar. The outcome will be the growth of hitherto and with conventional methods not accessible high-quality single crystals with large sizes, quantitative information about relevant intrinsic materials parameters such as anisotropic electronic conductivity and Li diffusion, and proper understanding of the ferrotoroidal properties in Li-based olivine phosphates. The main experimental work will be performed at U Heidelberg and ETH Zürich. The project results will yield valuable information for optimizing and tailoring nano- and microstructured Li-ion battery materials as well as on the potential of ferrotoroidicity for data storage, thereby providing an opportunity to European industry in cutting-edge technologies.