RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ultrafast Switching for High-Speed OTDM Networking' under Fifth Framework.

assistant: **Concept**

Optical time-division multiplex (OTDM) is a promising candidate for future optical networks to overcome present node capacity limitations, provided that existing long-haul links can be scaled up in bit rate and that network flexibility is ensured. The FASHION project is investigating OTDM point-to-point transmission and for the first time time-domain routing for all-optical networks at single-channel data rates of 160Gb/s and higher.Design rules are developed for maximised transmission reach and channel count at 160-Gb/s line rate, allowing the development of network concepts for mixed wavelength-division multiplexing (WDM) and 160-Gb/s OTDM. Experimentally, state-of-the-art 160-Gb/s transmission reach is extended to 500-1000km. Networking at 160Gb/s is demonstrated by developing a compact and reliable OTDM add and drop multiplexer (ADM). The developed technology will be evaluated both in the laboratory as in a field trial.Objectives:The general objective of the FASHION project is to assess the techno-economical potential of optical time-domain multiplexing (OTDM) in high-speed flexible optical networks. OTDM point-to-point transmission and time-domain routing will be investigated for single-channel data rates of 160Gb/s and higher.The transmission reach is planned to be extended to 500-1000km allowing wide all-optical networks. Supported by the analysis of physical system limitations, network concepts including economical considerations will be developed for mixed wavelength-division multiplexed (WDM) and OTDM multi-terabit systems. Time-domain add-drop multiplexers will be developed including an assessment of their impact on the transmission performance. System operation and capabilities will be evaluated in both laboratory and field experiments. For realistic network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Seed treatments for organic vegetable production' (STOVE), addressing dissemination and exploitation.

assistant: **Impact**

Due to the difficulty in organic farming of producing pathogen free seeds, and the lack of simple, effective non-chemical methods for seed sanitation, a substantial part of the seed used by European organic vegetable growers is still derived from conventional production. This will not be allowed after the year 2003 (EU Council regulation 2092/91). In the project two new physical seed treatment methods will be tested in relation to the traditional method of hot water treatment. Agents of natural origin acceptable to organic farming will be evaluated and combined with the physical methods. This will be complemented by studies on physiological factors determining seed sensitivity, which is in many cases limiting the application of physical seed treatments. The aim of the project is to improve the currently available, non-chemical methods for control of seed-borne vegetable pathogens and to develop new methods acceptable to organic farming.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tuneable Conditional Control of Engineered Bacterial Therapeutics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Engineered microbes are attractive platforms for the diagnosis and treatment of several diseases. For example, bacteria can selectively target tumors and are ideal vehicles for in situ delivery of therapeutic agents.However, as of today, no engineered living bacterial therapeutics in clinical trials have the ability for conditional control of therapeutic activity. This lack of reliable control over the timing and dosage of effector molecule production limits the specificity, safety, and efficacy of current bacterial therapies.In this project, I will use of a generalizable synthetic receptor platform to control the in vivo therapeutic activity of engineered bacteria using an externally administered molecules. As a proof of concept, I will use a receptor responding to a molecule found in the diet to control therapeutic release in tumors. I will use a safe probiotic, E. coli Nissle 1917, with demonstrated tumor targeting properties.In a first research line, I will characterize the dose-response and kinetics of synthetic receptors implemented in bacteria colonizing an in vitro 3D tumor spheroids model. I will then evaluate the therapeutic activity of strains producing cytolytic molecules in response to external inducer.In a second research line, I will characterize conditional control of gene expression and then therapeutic release in tumor mice model, using cytolytic and immunotherapeutic effectors.My work will deliver robust, safe, and efficient frameworks for conditional control of bacterial cancer therapy. By enabling in situ drug delivery with a highly-precise dosage and timing, it will allow physicians and ultimately the patients to finely control bacterial therapeutic activity.Because of its modularity my platform will be further engineerable to detect other conditio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'STI International Cooperation Network for Eastern Partnership Countries' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The project aims to support the advancement of the bi-regional STI policy dialogue between the EU MS/AC and the Eastern Partnership countries, with an explicit focus on the Societal Challenges that have been identified to be of mutual interest for the two regions, namely Climate Change, Energy and Health. In particular the project will identify actions and stakeholders and will implement innovative pilot activities to strengthen the coordination and impact of the individual actions.In terms of policy dialogue, the project will provide analytical evidence and monitoring to feed the dialogue and to support joint agenda setting. Policy mix reviews will be implemented along with capacity building activities with emphasis on the promotion of Innovation. More specifically, links with the EU technology platforms will be established allowing mutual learning and exchange of best practices for enhanced public-private partnerships between the two regions. In addition, support to FP contacts will be provided to strengthen their role and to adapt their functioning to the challenges of H2020.The proposed project will build on the experience of the previous projects (IncoNet EECA and IncoNet CA/SC) targeting the region and will develop synergies with the forthcoming project targeting the Central Asian countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Past, Present, and Future Lives of Soviet Housing Estates in the Baltic States' (2014-2020).

assistant: **Concept**

In Central and Eastern Europe (CEE), modernist housing estates, built between the 1950s and 1990s to meet housing demand and rebuild cities after World War II, introduced revolutionary changes in urbanization. Today, overcoming the challenges posed by vast housing estates presents one of the greatest challenges faced in post-Socialist cities. To address a gap in knowledge about socialist urban planning implementation (especially the construction of mikrorayon) in the Baltic States, I propose to interview planners and architects who were active practitioners during the Soviet era (as well as those practicing more recently) to analyse past, present, and future lives of housing estates in Estonia, Latvia and Lithuania. The project proposed for this IF is not only a natural progression of my research trajectory, it is also transformative because it applies my expertise to multi-disciplinary research that covers a range of research questions and avenues of inquiry. The project will produce broad impacts on research methods (interviews of original “actors” in residential settlements), new knowledge on the history of urbanization, and recommendations for present-day urban planning in cities in CEE.  This Individual Fellowship requires a 24-month academic stay at the University of Tartu (UT), Estonia where I will engage in training-through-research supervised by Prof. Tiit Tammaru, Professor and Senior Research Fellow in the Institute of Human Geography at UT. The project will give me new hands-on experience in interviewing and archival research and I will produce important publications that will (1) help me establish myself as the pre-eminent North American scholar on architecture, town planning, and urban geography in the Baltic States, and (2) assist my career advancement (f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DNA damage and the connection with cancer, premature aging and longevity', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We study DNA damage and genome stability and its impact on human health using nucleotide excision repair (NER) as paradigm. Patients with NER defects present a perplexing clinical heterogeneity ranging from extreme cancer predisposition to dramatic neurodevelopmental deficits. To elucidate the underlying mechanism we adopted an integral strategy from gene to patient and contributed to resolving the NER reaction in vitro and its dynamic organization in vivo, using molecular genetics, advanced life cell imaging and photobleaching. Mouse NER mutants revealed an unexpected link between DNA damage and (premature) aging, as strong as the DNA damage-cancer connection. We found a striking correlation between type/severity of the repair defect and degree of premature aging, with some mutants dying of aging in 3 weeks! Pathological and functional analysis and expression profiling confirmed that this is bona fide aging. Conditional mutants allowed targeting accelerated aging to specific organs/stages of development e.g. dramatic aging only in brain. Expression profiling revealed that short-lived repair mutants mount a  survival response  that attempts to extend lifespan by investing in defenses at the expense of growth. The ambitious objective of this multi-disciplinary proposal is to obtain an integral understanding of the biological/medical impact of DNA damage and the important survival response, with emphasis on rational-based prevention and intervention strategies for cancer and other aging-related diseases using the rapidly aging mouse mutants as tools. Triggering the  survival  response at adulthood is expected to postpone many aging-related diseases including cancer and to strongly improve quality of life at later age. We already identified compounds that influence rapid a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Marine cyanobacterial viruses: diversity and dynamics' (MARCYV).

assistant: **Concept**

Viruses are extremely abundant in the marine environment and are thought to profoundly influence ecosystem functioning. As host-specific agents of mortality they influence the population dynamics, diversity and evolution of their hosts. However, we are presently unable to assess the abundance or dynamics of discrete viral populations.Furthermore, estimates of viral-induced mortality are rudimentary at best, due to the lack of appropriate tools to quantify infected host cells. I propose to investigate the diversity of viruses that infect the ecologically important marine cyanobacteria, Synechococcus and Prochlorococcus, as well as assess their impact on host mortality. I will focus on the ubiquitous podoviruses for which little information is presently available. The diversity of cyanobacterial podoviruses will be determined by sequencing the DNA polymerase gene from podovirus isolates.We will use these findings to develop primers for the specific identification of cyanobacterial podoviruses and will employ a novel molecular approach, solid-phase polymerase chain reaction, for their quantification. The abundance and population dynamics of these podoviruses will then be determined over spatial and temporal scales in the Red Sea and will be compared to host population and total virus dynamics.Furthermore, this method will be used to amplify viral DNA from single cyanobacterial cells to investigate the extent of podovirus infection. The results from this research will significantly enhance our understanding of the influence of podoviruses on cyanobacterial mortality, population dynamics and community composition, and thus their impact on primary production and recycling of matter in the oceans.I bring to this project and Europe, unique expertise acquired in the US on physio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Organic-inorganic hybrid thermoelectric materials through a new concept of simultaneous vapor phase coating and infiltration (VPI/SCIP)' (HYTEM), addressing dissemination and exploitation.

assistant: **Impact**

In a world of enormously rising energy consumption and environmental pollution, the demand for clean and renewable energy sources and for minimizing the energy loss is of critical importance. One strategy towards improved efficiency involves capturing and recycling the “waste” heat from all energy conversion processes. With a special class of materials, known as thermoelectrics, thermoelectric generators can be devised, which allow a direct conversion of heat into electricity. The goal of HYTEM is to develop advanced organic-inorganic hybrid thermoelectric materials by applying a newly developed concept of simultaneous vapour phase coating and infiltration (VPI/SCIP) of polymers with inorganics. SCIP is a viable, scalable and robust preparative strategy for obtaining high-performance hybrid superlattice TE materials with chemically linked organic/inorganic interfaces, which have never been demonstrated before. The originality of this work lies in creating a new hybrid materials set, where hierarchical superlattice structures of different inorganic materials are simultaneously grown in the subsurface of a polymer and on its top, which will allow to obtain a superior TE performance. An initial growth of inorganic nanoparticles inside a polymer bulk by infiltration will generate nanoscale point defects in the polymer, which will reduce the thermal conductivity of the matrix by inducing phonon scattering, while at the same time the electrical conductivity will be enhanced.  To date, no work has been done to explore the potential of VPI/SCIP to generate hierarchical inorganic structuring in polymers. The knowledge gained from these experiments will have a great impact on the research of hybrid TEs due to the uniqueness of VPI/SCIP.


**Keywords:** Hybrid superlattice thermoe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of the Pollen-expressed FERONIA-like Receptor-like Kinases during Plant Fertilization' (PFERLS).

assistant: **Concept**

Fertilization relies on complex and specialized mechanisms that achieve the precise delivery of the male gamete to the female gamete and their subsequent union. In plants, the molecular mechanisms that mediate the discharge of sperm cells by the male gametophyte (pollen tube) into the female gametophyte are still a mystery although they are of great interest for the manipulation of breeding barriers in wide-crosses and the production of hybrids. Recently, it was shown that a molecular dialogue between the male and female gametophytes must occur for successful sperm discharge. A receptor-like kinase called FERONIA has been shown by U. Grossniklaus’s group (UZH, Switzerland), the Host Laboratory, to be required for this dialogue in the female gametophyte. The French Research Fellow Aurélien Boisson-Dernier initiated this project in his former laboratory (J. Schroeder’s group, UCSD, USA) and recently (November 16th 2008) joined U. Grossniklaus’s group to characterize PFERL-RLKs (pollen-expressed FERONIA-like receptor-like kinases), which are excellent candidates to assume the role of the FER counterpart in the male gametophyte. The project and the Research Fellow’s career will greatly benefit from the training and expertise offered by the Host Lab, as well as from its on-going in-depth characterization of FER-dependent signaling. This highly interdisciplinary proposal that includes molecular and cell biological, cytological, genetic, biochemical, and interactome approaches should result in the identification of the first components of the FER signaling counterpart in the pollen tube, essential for male-female gametophytic interactions and fertilization. Consequently, this project will allow the Research Fellow to establish himself as an independent leading scientist in Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Sustainable model for a trans-national technology transfer alliance implementing return-on-research Strategies'.

assistant: **Objectives**

The RTD institutions participating in STAIRS are fully aware of their enormous innovation potential and their societal commitments, driving them to actively turn that innovation potential into added value. In order to achieve this, they have created so-cal led alliances for commercialisation at a regional level since, due to a lack of critical mass, highly specialised commercialisation entities for each individual institution cannot operate profitably. These pilot regional experiences with distinct regional commercialisation models indicate that an upgrade of these regional TT-alliances to a trans-national level linking them with equally competent partners would generate a promising platform with increased efficiency thanks to synergy effects and an enlarged critical mass.A bundling of technological excellence and commercialisation efforts driven by a public-private-partnership creates a new scenario for trans-national technology transfer and paves the way for future TTT-challenges in a competitive environment. The major objective of the STAIRS project is to enhance technology transfer from renowned European RDT institutions to the market by implementing trans-national return-on-research strategies within a TTT-model. The partners are highly committed to interlink their successful regional models to a trans-national model and optimise it thanks to an exhaustive testing on selected hands-on TT-cases.The main expected result from the STAIRS project is a ready-to-use TTT-model composed of components developed and tested during the project. Due to a large dissemination activity IRCs and other commercialisation structures will become aware of the model developed within STAIRS and get the opportunity to adapt it to their own environments. The long-term vision of this project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improving PV acceptability through innovative architectural design-development: Demonstration, acceptability study in protected tourist regions' (1998-2002).

assistant: **Concept**

The existing barriers against broad implementation of Photovoltaics are manly non-technical, including design aspects. In sensitive areas under landscape and monument protection the existing PV modules don't meet aesthetic requirements.The objective of this project is to produce an assessment of the importance of design aspects for the dissemination of the technology, to develop innovative modules for application in sensitive areas and to test possible impact on user acceptance by assessing user and public reactions to selected demonstration objects realised during the project.Two protected tourist coastal areas (one each in North and South Europe) are the test-beds for the evaluation.Close co-operation between local communities (demand side), authorities (legal side), SMEs (technical development), research institutes (acceptability study), universities (design) and international monitoring groups will take place.