RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Health Impact of Engineered Metal and Metal Oxide Nanoparticles: Response, Bioimaging and Distribution at Cellular and Body Level'.

assistant: **Concept**

Metal oxide and metal NPs are particularly dangerous for two reasons: their special catalytic activity coming from the properties of their nanointerface may interfere with numerous intracellular biochemical processes and the decomposition of NPs and the ion leakage could heavily interfere with the intracellular free metal ion homeostasis, which is essential for cell metabolism. A very specific problem is the difficulty of localizing and quantifying them in cells. Obtaining dose effect relationships is not simple, because of the unknown amount of material present in affected cells. The following main points will be addressed in this proposal:1) Design and synthesis of metal oxide and metal NPs, which can be traced by SPECT, PET, and fluorescence techniques and  the appropriate characterization of these NPs.2) Application of label-free techniques, such as IBM and EM to ensure that the radioactive and fluorescent constituents do not modify the cytological and organismic response by themselves.3) Characterization of the uptake, distribution kinetics and NP release at the level of the organism.4) Study of the interaction of NPs with plasma components forming complexes with NPs and the assessment of their possible impact on the uptake compared with that of bare or capped particles.5) Quantification and localization of metallic NPs in immune competent cells is a key task for the establishment of proper dose-response correlations. A technique applicable with living cells as ultimate control will be IBM, capable of detecting single metal NPs in cells at different depths.6) Development of sophisticated cell physiological approaches focusing on the determination of oxidative activity, cytokine production and adaptive processes concerning signalling pathways beyond standard vitalit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Targeting replication stress recovery pathways in oncology' in the context of a Horizon 2020 call.

assistant: **Objectives**

Genomic instability characterizes tumors, which have no clear ‘oncogenic-driver’ mutation, including triple-negative breast cancers (TNBCs). These patients do not benefit from molecularly targeted treatment and urgently need better treatment options. Increasing evidence points to replication stress as the driver of genomic instability. Since replication stress compromises cell viability, cells have evolved mechanisms to mitigate this threat. Recently, I discovered a novel cellular mechanism—mitotic Replication Stress Recovery (RSR)—that acts as an ‘emergency brake’ during mitosis, allowing recovery from high levels of replication stress. This machinery is critical for tumor cell survival, and therefore constitutes a promising target for anti-cancer drug development. However, it is unclear how this mitotic RSR is organized molecularly and how it can be targeted therapeutically.In this project, I aim to molecularly define and therapeutically target the Mitotic Replication Stress Recovery (RSR) machinery in triple-negative breast cancer cells.To this end, I will implement a series of complementary innovative strategies. First, I will use mass-spec-based proteomics to molecularly characterize components and wiring of the mitotic RSR machinery. Second, to identify the genetic profiles of cancer subgroups that are sensitive to inactivation of the mitotic RSR, functional genetic screens will be combined with visualization and quantification of replication stress in genomically-defined human cancer samples. Finally, my findings will be translated to the pre-clinical situation by exploring the feasibility of therapeutic inactivation of the RSR machinery in vitro and in vivo in a panel of triple-negative breast cancer models.In summary, TENSION will provide advanced insight into
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High capacity all-solid-state silicon-lithium-sulfide cells for energy storage applications' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Rechargeable energy storage systems attract worldwide scientific and industrial interest due to their widespread applications. From the perspective of single customer, these batteries have been found useful in various portable devices and even in electric vehicles (EVs). Being practical in many circumstances, they have even more distinct role in reducing global warming and the emission of greenhouse gases. Together with the limited sources of fossil fuels, these aspects have driven the efforts to utilize more green sources of energy like wind and solar power, aiming at sustainable energy production. One critical factor on the way to zero-carbon footprint is to change the transportation to function solely with green electricity. The current EV industry depends heavily on lithium-ion batteries which face technological challenges like limited storage capacity and safety concerns related to the use of liquid electrolytes. Further, these batteries utilize materials that are far from being sustainable and environment friendly. To address these issues, the proposed SiLiS project will focus to develop new battery technology employing high-capacity silicon anode, lithium sulfide-based cathode, and stable and safe polymer based solid electrolyte. The project will support the development of cost-effective batteries to reduce greenhouse gas emissions from transportation by means of electric vehicles. The proposed all-solid-state silicon-sulfur cells (SSCs) is expected to have the gravimetric energy density of 750 Wh/kg, power density of 1500 W/kg and volumetric energy density of 1300 Wh/L.  The novel high energy density battery will be of low cost, with a prolonged cycle life which is better than the current Li-ion battery. Thus, SiLiS will develop next generation rechargeable batt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A living carbonate factory: how do cyanobacteria make rocks? (Calcification in Cyanobacteria)' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This interdisciplinary proposal stems from our recent discovery of deep-branching cyanobacteria that form intracellular Ca-Mg-Sr-Ba carbonates. So far, calcification by cyanobacteria was considered as exclusively extracellular, hence dependent on external conditions. The existence of intracellularly calcifying cyanobacteria may thus deeply modify our view on the role of cyanobacteria in the formation of modern and past carbonate deposits and the degree of control they achieve on this geochemically significant process. Moreover, since these cyanobacteria concentrate selectively Sr and Ba over Ca, it suggests the existence of processes that can alter the message conveyed by proxies such as Sr/Ca ratios in carbonates, classically used for paleoenvironmental reconstruction. Finally, such a biomineralization process, if globally significant may impact our view of how an ecosystem responds to external CO2 changes in particular by affecting most likely a key parameter such as the balance between organic carbon fixed by photosynthesis and inorganic carbon fixed by CaCO3 precipitation.Here, I aim to bring a qualitative jump in the understanding of this process. The core of this project is to provide a detailed picture of intracellular calcification by cyanobacteria. This will be achieved by studying laboratory cultures of cyanobacteria, field samples of modern calcifying biofilms and ancient microbialites. Diverse tools from molecular biology, biochemistry, mineralogy and geochemistry will be used. Altogether these techniques will help unveiling the molecular and mineralogical mechanisms involved in cyanobacterial intracellular calcification, assessing the phylogenetic diversity of these cyanobacteria and the preservability of their traces in ancient rocks. My goal is to establi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Working Group to Boost Euro-Latin American Joint Activities in Industrial and Societal Applications of Information Society Technologies', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The general objective is to implement a series of Thematic Action Plans (TAPs) in areas of application of Information Society Technologies of interest to both the European and Latin American regions, based on a series of highly focused Thematic Workshops. Specifically the Thematic Action Plans will be implemented via proposals for joint Euro-Latin American collaboration projects in these domains to be submitted to the relevant EU and Latin American programmes, in particular the EU FP5 IST Programme.Objectives:The boost joint Euro-Latin American collaboration in areas of application of Information Society Technologies of importance for the social and economic development of the region. This will be achieved via the implementation of Thematic Action Plans in areas such as Electronic Commerce and New Ways of Working, as well as in Healthcare, Tourism, Administration, and the Management of Natural Resources. The Thematic Action Plans will be developed in Thematic Workshops. They will be implemented via actions arising out of the workshops and via proposals consequently presented to the IST Programme.Work description:The first step in the implementation of the Thematic Action Plans will be the organization of 8 Thematic Workshops held in Latin America, on themes decided in consultation with the members of the Euro Latin American Information Society Steering Committee. The Steering Committee is an informal group of high-level individuals from industry, research and government. They represent all 34 countries of the Euro-Latin American region. Their experience and input will ensure that relevant themes are addressed and that appropriate organisations are involved in the Thematic Workshops. The Thematic Workshops will be prepared with technical assistance from experts and organ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developments in the management of human resources in Austria and Sweden - cases from the banking and electronic industries' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this study is to examine developments in the management of human resources in Austria and Sweden. Key research questions are: - what Human Resource Management (HRM) approaches are pursued by companies operating in Austria and Sweden?, -what outcomes in terms of employment growth do different HRM approaches pursued by companies in Austria and Sweden have?, -is EU membership leading to a destabilisation or shaking up of the Austrian or Swedish system of HRM? -is there any development towards a unitarist US type HRM in Austrian or Swedish companies? The research consists of a secondary analysis of survey results, expert interviews and eight detailed case studies of human resource practises of banks and electronic companies. On a practical level the results of the research project can give policy advise to Austrian and Swedish employers about the applicability of US HRM prescriptions and the viability of more traditional human resource approaches. EU policy makers will get insights into the way European integration affects human resource management practises, as well as possible links between HRM practises and employment levels. In addition, the results will contribute to the academic debate about the convergence or divergence of human resource practises in Europe as well as the suitability of American management concepts for companies operating in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biologic Lycopene from Tomatoes' (BioLyco).

assistant: **Concept**

Licofarma aims to be the first company to bring on the market Organic Lycopene, produced without chemical solvents from fresh organic-certified tomatoes, through a unique, internationally patented process technology. Lycopene is an antioxidant compound very important for human health, preventing a number of life-threatening and chronic diseases. Despite its benefits, Lycopene has two problems: it has to be taken through diet, as the body cannot produce it, and current production processes involve chemical solvents and toxic impurities. Licofarma patented technology extracts Lycopene from organic- quality tomatoes without any chemical solvents, using only CO2 in supercritical conditions. The end product has unmatched quality features: absence of toxic agents and impurities, high bioavailability, high antioxidant and cancer-prevention properties, high-quality food colouring, 100% natural and organic certification and environment-friendly and safe production process. Competitor products are Synthetic lycopene from chemical synthesis, which has lower cost, high presence of toxic agents and poor quality, and Natural lycopene from tomatoes, which has average cost, still toxic agents and lower quality than Licofarma’s product. Both products cannot be organic certified and have high impact on environment and safety. Organic Lycopene will be offered on the market in bulk form, for producers, and directly to consumers as ingredient of dietary supplements and ophthalmic products. The Lycopene production market value is foreseen at 84M€ in 2018 (300 tons/year) with yearly growth higher than 3%. Licofarma target is to reach an annual production of about 10 tons/year (3,2% share). The product will boost growth of the company, generating almost 40M€ cumulated revenues in 5 years and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'AFRICA-GHG: The role of African tropical forests on the Greenhouse Gases balance of the atmosphere' (AFRICA-GHG).

assistant: **Concept**

The role of the African continent in the global carbon cycle, and therefore in climate change, is increasingly recognised. Despite the increasingly acknowledged importance of Africa in the global carbon cycle and its high vulnerability to climate change there is still a lack of studies on the carbon cycle in representative African ecosystems (in particular tropical forests), and on the effects of climate on ecosystem-atmosphere exchange. In the present proposal we want to focus on these spoecifc objectives : 1. Understand the role of African tropical rainforest on the GHG balance of the atmosphere and revise their role on the global methane and N2O emissions. 2. Determine the carbon source/sink strength of African tropical rainforest in the pre-industrial versus the XXth century by temporal reconstruction of biomass growth with biogeochemical markers 3. Understand and quantify carbon and GHG fluxes variability across African tropical forests (west east equatorial belt) 4.Analyse the impact of forest degradation and deforestation on carbon and other GHG emissions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Is environmental justice necessary for human well-being? Comparative analysis of certification schemes, inclusive business, and solidarity economy strategies' under Horizon 2020.

assistant: **Concept**

Unprecedented concentration in agri-food value chains is reinforcing global inequality. Waves of land grabbing threaten the livelihoods of millions. Reshaping the effects of agricultural investment, land use, and trade on human well-being is thus an urgent challenge. Certification schemes (CS) such as Fairtrade have become a common strategy to meet this challenge. However, accumulating evidence shows that many CS have limited effects on well-being. Inclusive business (IB) and solidarity economy (SE) strategies are emerging alternatives. Inclusiveness and solidarity are widely believed to enhance well-being, but evidence and theories disprove this common belief. Environmental justice may be a necessary condition to understand and reshape the effects of CS, IB, and SE on well-being. However, lack of reliable data and comparative analyses limits understanding of these links. COMPASS will tackle these challenges. This project aims to demonstrate how environmental justice influences the effects of CS, IB, and SE strategies on human well-being. COMPASS is organized in four work packages (WPs) and focuses on the cocoa and coffee sectors of Peru and Switzerland. WP1 surveys organizations (n=120) to compare their instruments used in CS, IB, and SE strategies. WP2 surveys households (n=840) and uses set-theoretic and process-tracing methodology to explain the effects of CS, IB, and SE on well-being. WP3 identifies the rules that organizations (n=18) create to regulate land use, investment and trade, assesses their environmental justice, and explains how they influence well-being. WP4 generates context-sensitive generalizations of these effects, and it tests and advances pertinent theories. COMPASS breaks new ground by systematically comparing CS, IB, and SE strategies and their e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bottom Up selection, collection and management of URBAn waste' (BURBA), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the BURBA project is to develop an automatic system to be used for intelligent waste management. The system consists of intelligent waste containers and an IT tool for waste collection and transport management, including RFID’s (Radio Frequency Identification) ability to reliably identify individual receptacles, users, single marked items or waste categories, and cell-phone-based LBS’ (location-based service) ability to allow an easy identification of the geographical position of the most suitable waste container and to improve its utilization by the citizen (the closest one to user actual position, not full, adequate for that waste category, etc). The BURBA rugged system is integrated into “intelligent waste containers” with capacities of 600 litres and over, for urban and industrial waste collection. It includes electronics for data transmission, for quantity and quality of waste measurement and a power pack that may be recharged using environmental energy scavenging. The foreseen IT tool will exploit the collected data in the frame of an advanced Waste Management concept. It will manage appropriately position and time of collection and optimize truck fleet path and queuing to waste disposal plants (for example incinerators that need continuous adequate feeding in quantity and quality); as well as the differential waste disposal to feed recycling facilities. It will compute service metrics and parameters for decision making and resources allocation. It will so far contribute to improve the management of the waste transport vehicles fleet, to minimise transportation path and diminish fuel expenditures as well as to optimise gain of disposal plants and service to citizens and industrial companies avoiding overfilled containers. Additional features of the plat