RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhanced real time services for an optimized multimodal mobility relying on cooperative networks and open data' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Europe would be close to solving problems related to congestion, traffic safety and environmental challenges if people, vehicles, infrastructure and business were connected into one cooperative ecosystem combining integrated traffic and transport management with new elements of ubiquitous data collection and system self-management. The main objective is increasing the safety, sustainability, flexibility and efficiency of road transport systems by taking advantage of cooperative communication and by processing open data related to travel through a cooperative open web based platform and mobile application, developed with the purpose of delivering information and services to drivers, businesses and Vulnerable Road Users in real time. The operative objectives will be to:- Analyse stakeholder’s needs incorporating them in the specification of the transport services delivered by the platform;- Identify transport open data sources of information and harmonizing this data to be used as real-time information;- Define and implement and fully distributed global architecture to enable cooperative sensing in ITS;- Leverage the information gathered from vehicular communications, GNSS and open data by means of artificial intelligence techniques;- Develop hybrid networks, supporting 802.11p and mobile communications, which will allow assuring a stable communication channel between vehicles and VRU (usually bringing smartphone). - Empower drivers to deliver data to the platform by leveraging the information generated by their mobile phones exponentially increasing the information available on traffic status.- Implement ITS services arranged in the following main areas: driver assistance, vulnerable users and multimodal dynamic commuter, enhanced real time traffic information API and TI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Interdisciplinary approach to characterize the structure and the ion transport mechanism of NKCC1, a key target for brain disorders.' in the context of a Horizon 2020 call.

assistant: **Objectives**

Neurodevelopmental disorders affect millions of children in Europe and worldwide. A large body of literature indicates that inhibitory GABAergic transmission thorough Cl-permeable GABAA receptors is defective in many of these disorders. However, effective pharmaceutical treatments are still needed. There is increasing scientific evidence that varying the intracellular Cl concentration is one of the more physiological and effective ways to modulate GABAAergic transmission. This concentration is mainly established by the Cl importer NKCC1 and the Cl exporter KCC2. Importantly, the NKCC1/KCC2 ratio is defective in several brain disorders. Moreover, NKCC1 inhibition by the FDA-approved diuretic bumetanide rescues many symptoms in animal models. These findings have already led to clinical studies of bumetanide to treat a broad range of brain disorders. However, this requires chronic treatment, which poses serious issues for drug compliance, given the diuretic effect of bumetanide caused by the inhibition of the kidney-specific Cl transporter NKCC2. Crucially, these issues could be solved by selective NKCC1 inhibitors, which would have no diuretic effect. Yet there is still very little knowledge of the structure-function relationship of NKCC1 in terms of ion transportation and how bumetanide acts on NKCC1. The main goal of this fellowship is to resolve NKCC1’s structure using X-Ray crystallography and/or cryo-electron microscopy. This effort will be coupled to the functional characterization of NKCC1 using in vitro and in silico approaches. The fellow will thus integrate her research skills with key expertise in the structural and molecular biology of ion transporters, allowing her to grow into an independent group leader. Ultimately, this project will provide unprecedented i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrative approach for the emergence of human-like robot locomotion'.

assistant: **Objectives**

The development of a robotic humanoid is one of the recurrent human dreams of all ages. Environments in which humans operate or live are specially made for and structured to their locomotion and manipulation capabilities. In healthy humans, walking emerges naturally from a hierarchical organization and combination of motor control mechanisms. Artificial bipeds have not reached performance comparable to human behaviour. Major drawbacks of these bipeds and control concepts are related to their stability and energy consumption.<br/>The goal of H2R project is to demonstrate human-like gait and posture in a controlled compliant biped robot as a result of a hierarchical organization and combination of the most relevant motor control mechanisms found in humans. This will be done integrating the human-like mechanical principles and control strategies currently applied in the three actual prototypes ESBiRRo, Veronica and Posturob, into a behavior-based hierarchical architecture proposed by the iB2C approach. This process will result in a novel reflex-based controlled passive walker, built around the ESBiRRo platform.<br/>H2R biped, will allow, to some extent, capturing human functional morphology and passive dynamics features. The behaviour-based control structure will allow for hierarchical strategies and combination of feed-forward and feedback control, thus supporting spinal motor patterns for bilateral synchronization of gait phases and stabilization by means of spinal reflexes. The system will include human-like vestibular and visual sensory systems, to allow for supraspinal postural reflexes. The behaviour-based control architecture will be combined with novel learning schemes and prediction strategies in which biomechanical, neuromotor and cognitive key features of human
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced Single Cell tEstiNg and Development of HT PEMFCs' (ASCEND), addressing dissemination and exploitation.

assistant: **Impact**

The core priorities of Horizon 2020 - Work Programme 2018-2020 “Secure, clean and efficient energy” are renewable energy, smart energy systems, energy efficiency, and carbon capture utilization and storage. In-line with these priorities a scalable electric power source is produced by Serenergy A/S. The product can be used for applications both off- or on-grid, and is based on reformed methanol high-temperature proton exchange membrane fuel cell (HT PEMFC) system. Constant improvements and innovations of the product require strong R&D and quality control (QC) activities. This applied research project (ASCEND) will address challenges and issues encountered in the core components of the HT PEMFC stack, namely the processes and phenomena inside the membrane electrode assembly (MEA) and its subcomponents.ASCEND aims to develop diagnostic tools, to better understand and further improve the HT PEMFC stack, by introducing a newly designed test station. This station will be used to test prototype MEAs (and various subcomponents) with the goal of obtaining relevant data and feedback suggestions for improving materials and processes used in production and assembling of MEAs and stacks. The purpose of this test station will be twofold: to carry out QC and to support R&D activities related to stack development and fuel cell functionality and durability. For successful implementation of this new paradigm several research objectives have been set, which will be addressed by using a variety of advanced experimental techniques and methodologies. This new paradigm will allow studying current and novel materials and/or components well beyond the completion of this project and enable collaborations in other research projects and thus faster transition to new state-of-art materials or compo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nanoelectromechanical Infrared Detector' (NIRD).

assistant: **Concept**

The aim of this proposal is to develop an uncooled nanoelectromechanical detector for infrared (IR) and terahertz (THz) radiation, which surpasses the sensitivity of state-of-the-art uncooled detectors by up to two orders of magnitude. The reliable and quantitative sensing of light is a fundamental task ubiquitous to modern technology. The IR to THz region of the electromagnetic spectrum hosts a wealth of intriguing interactions between radiation and matter, which are of particular interest for a wide range of applications including quality control in food and agriculture, drug development in pharma, medical imaging, security scanning, environmental monitoring, astronomy, and fundamental research. Because of the low energy of IR/THz photons, highly effective photodiodes don’t exist in this region and detectors typically rely on less sensitive thermal detectors. In order to reach sensitivities comparable to what is obtainable with photodiodes in the visible and near IR region, thermal IR detectors require cryogenic cooling. In our ongoing work on photothermal coupling of nanoplasmonic antennas and single molecules to nanomechanical resonators (ERC-StG PLASMECS), we have recently obtained an extraordinary sensitivity of 16 fW/rtHz at room temperature in the visible regime, which even exceeds the sensitivity of state-of-the-art LHe cooled bolometers. The ERC PoC grant would allow us to develop our current nanomechanical sensor further to an innovative uncooled IR/THz detector with unprecedented sensitivity. The resulting detector would constitute a breakthrough by improving the current sensitivity of state-of-the-art uncooled detectors to the fundamental photon noise limit. Such a detector would not only spur IR-THz-research, but more importantly, without the need of cryog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dissecting the role of the immune microenvironment in the onset of myelodysplastic syndromes', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem-cell malignancies of the elderly. MDS remain uncurable by existing pharmacological therapies, aimed at eradicating mutant clones. Clonal cytopenias of undetermined significance (CCUS) occur in elderly patients harboring MDS-driver mutations in their bone marrow cells and almost always preclude MDS, representing an optimal setting for studying the mechanisms driving the onset of MDS. In a preliminary study, I discovered that innate immune cells from patients with CCUS are transcriptionally rewired toward their activation but have signs of functional exhaustion and dysfunction. Therefore, I hypothesized that dysfunctions in the immune microenvironment favor clonal expansion and disease progression in early stages of MDS and, therefore, therapeutic approaches enhancing the immune response in CCUS or MDS patients may effectively prevent or arrest disease onset. To test my hypothesis, in this project I will dissect the role of the immune microenvironment in the expansion of premalignant clones in early-stage MDS. To do so, I will 1) transcriptionally and immunophenotypically characterize the immune microenvironment in MDS patients with low clonal burden at the single-cell level, including interactions between immune and non-immune cells; 2) assess the functionality of the immune cell repertoire in CCUS and MDS patients through the analysis of their secretome and the cells’ secretory and cytolytic functions; and 3) test the feasibility of targeting immune responses in MDS by performing proof-of-principle drug testing assays with new-generation immune checkpoint inhibitors and identifying and validating novel therapeutic targets. I expect the results of this project to shed light on the cell-extrinsic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Quality improvement through verification process'.

assistant: **Innovation**

Scope of the experiment is to define a verification process in terms of activities, methods, tools, measurements integrated with the development phase of our CAD software products. The experiment will be applied to our main business product for three-dimensional design called Eureka, on which we will measure the benefits in terms of quality attributes: functionality and reliability (as required by the customer), maintainability and portability (for the organisation). The PROVE idea was born out of an assessment of the guideline ISO 9001: the study pointed out that the definition of a verification process is a primary need for the improvement of the product quality and the benefits on the whole development process. The high complexity of our process of software development, due to the technical contents and of the continuous and crucial adaptation to the technological evolution, creates in fact the necessity for a verification process parallel to the software development phase (design, code writing, porting), which includes testing and product inspection.THE EXPERIMENTThe verification process will be structured as follows:- identification of the quality characteristics and their measurable attributes- sub specification classification (checklist) for each subsystem of the baseline project.- definition of the verification activity (testing, code inspection, etc..) to ensure these characteristics- analysis and evaluation of acquisition and/or customisation of automated testing instruments- definition of metrics and criteria for the evaluation of the resultsThe final step of PROVE, will be the institutionalisation of the defined practices (documentation of standards, test operating manuals, etc.), necessary to the dissemination by the internal quality function.EXPECTED IMPAC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Capitalizing on Gravitational Shear' (COGS).

assistant: **Concept**

Our Universe appears to be filled with mysterious ingredients: 25 per cent appears to be dark matter, perhaps an as-yet undiscovered particle, and 70 per cent seems to be a bizarre fluid, dubbed dark energy, for which there is no satisfactory theory. Solving the dark energy problem is the most pressing question in cosmology today. It is possible that dark energy does not exist at all, and instead Einstein s theory of General Relativity is flawed. Cosmologists hope to measure the properties of the dark energy using the next generation of cosmological observations, in which I am playing a leading role. I believe the most promising technique to crack the dark energy problem is gravitational shear, in which images of distant galaxies are distorted as they pass through the intervening dark matter distribution. Analysis of the distortions allows a map of the dark matter to be reconstructed; by examining the dark matter distribution we uncover the nature of the apparent dark energy. However to capitalize on the great potential of gravitational shear we must measure incredibly small image distortions in the presence of much larger image modifications that occur in the measurement process. I am proposing a fresh look at this problem using an inter-disciplinary approach in collaboration with computer scientists. This grant would enable my team to play a central role in the key results from the upcoming Dark Energy Survey. We would further capitalize on the gravitational shear signal by moving away from the current dark energy bandwagon by instead focusing on testing General Relativity using novel approaches. Our work will produce results which will lead the next Einstein to solve the biggest puzzle in cosmology, and arguably physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanistic principles of regulation by small RNAs'.

assistant: **Innovation**

Small RNAs (sRNAs) are major regulators of gene expression in bacteria, exerting their regulation in trans by base pairing with target RNAs. Traditionally, sRNAs were considered post-transcriptional regulators, mainly regulating translation by blocking or exposing the ribosome binding site. However, accumulating evidence suggest that sRNAs can exploit the base pairing to manipulate their targets in different ways, assisting or interfering with various molecular processes involving the target RNA. Currently there are a few examples of these alternative regulation modes, but their extent and implications in the cellular circuitry have not been assessed. Here we propose to take advantage of the power of RNA-seq-based technologies to develop innovative approaches to address these challenges transcriptome-wide. These approaches will enable us to map the regulatory mechanism a sRNA employs per target through its effect on a certain molecular process. For feasibility we propose studying three processes: RNA cleavage by RNase E, pre-mature Rho-dependent transcription termination, and transcription elongation pausing. Finding targets regulated by sRNA manipulation of the two latter processes would be especially intriguing, as it would suggest that sRNAs can function as gene-specific transcription regulators (alluded to by our preliminary results). As a basis of our research we will use the network of ~2400 sRNA-target pairs in Escherichia coli, deciphered by RIL-seq (a method we recently developed for global in vivo detection of sRNA targets). Revealing the regulatory mechanism(s) employed per target will shed light on the principles underlying the integration of distinct sRNA regulation modes in specific regulatory circuits and cellular contexts, with direct implications to syn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New Process and Machinery for Microparts Moulding based on Ultrasound excitation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of Sonoplast is to enable a completely revolutionary concept of plastification and moulding process of micro and mini parts based on the use of ultrasounds to respond flexibly, reliably and cost effectively to the need of micro system suppliers for the production of complex shaped and functional μ-parts. The objective of the Sonoplast project is the development and construction of the first ultrasounds based moulding machine for the production of plastic parts in the micro and mini scale size. The development of the new machine will need the complementary production of a new concept of mould and plastic feeding system adapted to the physical principles of ultrasounds and mechanical features (kinematics) of the new moulding machine. Thus Sonoplast is a project bottom-up oriented because the involved SMEs companies cover the whole supplying chain, showing complementary skills in the product development (product design, mould making, injection moulding, injection machine manufacturing).