RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tropical Micro-Archaeology:An interdisciplinary project aiming to study site formation processes in tropical environment related to hunter-gatherers' use of space' to be submitted under Seventh Framework.

assistant: **Abstract**

TropicMicroArch aims to study how hunter-gatherers' ways of living are reflected in their use of space and how it affects the depositional processes of microscopic materials in tropical forests. Although hunter-gatherers' use of space has previously been studied through Ethnoarchaeology, this project proposes to study it from a new microscopic perspective with special attention given to post depositional processes. In comparison to arid, semi-arid and temperate environments, site formation processes at tropical forest open air sites have not yet been studied in detail. This project will develop methods of sediments sampling and mapping and methods of laboratories analyses of microscopic remains which will aid the archaeological research to analyze the use of space among prehistoric hunter-gatherers and to understand and observe formation processes in tropical sites.This will be achieved by conducting ethnographic and geoarchaeological fieldwork, geochemical analyses and spatial mapping. Fieldwork will centers on living and abandon settlements of a contemporary hunter-gatherer community in the tropic forests of South India. Research will take place in the McDonald Institute for Archaeological Research in the University of Cambridge, where the integration of humanities, social sciences and exact sciences is possible. Due to its multidisciplinary properties, this study will involve several host scientists and mentors from the Department of Anthropology and Archaeology at Cambridge University, in addition to collaboration with researchers from other departments and institutes from Europe and Asia. The fellow will benefit from the interplay and integration of scientific practice and theory in Cambridge University. He will gain invaluable training and experience as a member o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Polymer coated macroporous ceramic scaffolds for tissue engineering'.

assistant: **Concept**

Bone tissue engineering is a new research area with clinical applications in the replacement of diseased or damaged bone tissues. The challenge of tissue engineering is to develop a suitable bone scaffold with sufficient porosity and mechanical strength to allow for cell adhesion, migration, growth, and proliferation, resulting in a good integration with the surrounding tissues. The aim of this project is the development and the characterisation of novel macroporous scaffolds made of ceramic/polymer composites, with controlled biodegradability, to be used for drug delivery systems in tissue engineering applications.Our purpose is to prepare, by using different techniques, composite scaffolds made of a macroporous bioactive ceramic and a biodegradable polymer coating, which will be loaded with relevant macromolecules or growth factors. By combining biodegradability and bioactivity, optimised scaffolds for tissue engineering can be produced. Moreover, the biodegradable scaffold can be used as a controlled delivery system; in this application, the porosity controls the amount of drugs (antibiotics, antimicrobials, and growth factors) that can be incorporated.Optimisation of the scaffold structure is essential to achieve both adequate mechanical and biological response of the composite for applications in tissue engineering. To enhance the composite - tissue biological interaction is important to obtain an interconnected porous structure of the scaffold. We will investigate the macro and microstructure of the porous composites. Moreover, we will study the mechanical, biological, and clinical response of the novel ceramic - polymer composite after contact with simulated body fluid and relevant cells. Cell culturing experiments will be carried out to assess the biological beh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multilayer Photonic Circuits made by Nano-Imprinting of Waveguides and Photonic Crystals' (FIREFLY) under Seventh Framework.

assistant: **Objectives**

The objective of FIREFLY is the introduction of novel polymer waveguide and photonic crystal structures based on highly structured 3D nano-hybrids into industrial applications by using a new cost effective production process for larger scale manufacturing. The target applications are optical waveguides and photonic structures for the manipulation of light in, for example, optical interconnects. The optical interconnects technology will initially be applied for data communication in high performance supercomputers, and eventually these optics will also find their way into high-end server systems, mid-range servers and in consumer-like applications such as high-end multimedia devices.Waveguides and photonic crystals based on polymers have been proven in a laboratory environment to be interesting technologies for light management. In most cases these structures are manufactured on small scale. We propose the use of a relatively new technology to manufacture these structures on a larger scale.The nano-hybrids will be manufactured using a combined approach of nano-imprint process in a polymer resins and self assembly of material in the polymer nano-structures. The nano-structures will be filled with new modified polymer compositions having a high refractive index and optical clarity at relevant wavelengths, necessary for waveguides, and with inorganic nanoparticles to prepare photonic crystals, for the manipulation of light for guiding the light in waveguides through sharp horizontal and vertical bends. Some material developments are needed: new silicone polymers that will be modified for improved optical properties such as low optical loss and tuneable refractive index, and new inorganic particles that will combine a high refractive index with a very high level of monodispe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New Tools for Real-Time Cellular Imaging and Protein Labelling' under Seventh Framework.

assistant: **Concept**

The primary aim of the proposed research is to develop smart new imaging tools and reagents for real-time in situ monitoring of specific cellular processes both in vitro and in vivo, with a particular focus on lung function and apoptosis/inflammation. The methods and tools currently available to define the inflammatory/infective state in lung tissues are limited and crude. Therefore, I will design, synthesise and validate novel clinical molecular imaging probes which can, in the future, be used to define the inflammatory and infective aetiology of lung infiltrates in intensive care unit patients. These dual probes would allow clinicians in intensive care units to rapidly and accurately determine the aetiology of deteriorating respiratory function or clinical status of the patient. These activity-based probes are designed to detect caspase, human neutraphil elastase as well as bacterial presence and activity in the target tissue. The research will be conducted at the interface of chemistry, biology and pre-clinical medicine, with molecules being made and then directly applied in pertinent in vivo models. In addition to the imaging work, I will develop an efficient, selective and generic labelling method for proteins.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The early metabolic stages in the evolution of antimicrobial resistance' in the context of a Horizon Europe call.

assistant: **Objectives**

Antimicrobial resistance (AMR) is a rising global health threat and rapid evolution of resistance against existing or newly developed antibacterial compounds is predicted to lead to 10 million deaths and $60 trillion of lost economic output by 2050. While resistance-conferring mutations, their inheritance and spread by horizontal gene transfer are increasingly well-studied, our understanding of “pre-resistant” cells’ survival and resilience in the presence of lethal antibacterial doses remains unclear. This proposal is stimulated by recent findings suggesting that the extracellular metabolic environment and metabolic adaptations play an overlooked role in transiently buffering antibiotic lethality and, therefore, increase the emergence of subpopulations of cells and their effective size that supports the evolution of antimicrobial resistance. In this proposal, I will systematically dissect mechanisms at work in subpopulations of “pre-resistant” cells of priority pathogens Pseudomonas aeruginosa and Acinetobacter baumannii that can transiently cope with antimicrobial treatment. I propose to combine my expertise in bacterial physiology with the Ralser Lab’s ultra-fast, massive-scale proteomics and phenomics technologies. I will systematically investigate the metabolic stress response in clinically relevant conditions, and identify the key metabolic and signalling processes that support the survival of subsets of challenged cells upon exposure to major classes of clinically applied antimicrobials. Finally, adaptive evolution experiments combined with CRISPR/Cas9 gene editing will validate causal effectors of identified tolerance mechanisms that precede the appearance of resistance-conveying adaptations. Here, I will acquire technical skills in innovative technologies and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel Approaches to Determine Molecular Mechanisms of Pathogenesis in Tuberculosis' (TB-PATH) under Seventh Framework.

assistant: **Objectives**

I initiated and developed an unbiased comprehensive study using whole genome array analysis of the transcriptome in blood of tuberculosis (TB) patients and provided global knowledge of the immune response and potential factors leading to TB pathogenesis. Using larger cohorts of TB patients and controls than previous studies, together with complementary analytical approaches of modular, pathway and gene level analysis, we identified a striking interferon (IFN)-inducible neutrophil-driven signature of active TB. This IFN-inducible gene signature correlated with extent of radiographic disease and was represented by Type I IFN as well as IFN-gamma-inducible genes. We propose to apply the knowledge obtained from our study of human TB to study in depth the potential role of Type I IFNs and Type I IFN-inducible genes in TB pathogenesis in susceptible genetic strains of mice infected with virulent Mycobacterium tuberculosis (MTb) strains. We propose to develop a modular tool to study complex transcriptional data in blood from mouse models of disease, as has been done for human disease, to allow accurate comparison of mouse models with human TB, and allow rapid analysis of the immune response at the transcriptional level to reflect pathogenesis, but also in the study of MTb-infected mice where potential pathways of pathogenesis have been perturbed. Based on our findings in human TB we propose to test the hypothesis that Type I IFN and genes induced by this pathway during TB, including Tripartite motif-containing proteins (TRIMs), are important determinants of pathogenesis. This will be achieved by their elimination or perturbation in susceptible TB models and in MTb-infected macrophages, dendritic cells, and neutrophils to define molecular mechanisms contributing to their role i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An enhanced resolution modelling study on anthropogenic climate change' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives : To assess the anticipated change in climate after a doubling of the carbon dioxide concentration in the atmosphere with special emphasis on the hydrological cycle and the characteristics of tropical cyclones. Brief Description of the Research Project : The project is aiming at the assessment of the anticipated change in climate after a doubling of the carbon dioxide (CO2) concentration in the atmosphere by means of a numerical modelling study employing a state of the art atmospheric general circulation model (AGCM). Along with this goes an assessment of the AGCM's capability in simulating the present day climate realistically. The model employed is the ECHAM4 AGCM. The simulations have been performed at high horizontal resolution, that is a triangular truncation at zonal wavenumber 106 (T106), so that they include numerous regional features and, hence, lead to a considerable improvement of the overall presentation of various aspects of climate in the model. We consider three different simulations in the project. Two of them, covering a period of 30 years each, represent the present day climate and the climate at a time, when the CO2 concentration in the atmosphere has doubled. For these so-called time-slices the lower boundary fields have been extracted from a simulation with a low resolution coupled atmosphere-ocean general circulation model. For the third one, a simulation of the present day climate covering a period of 16 years, the lower boundary fields have been constructed from observational data. The project concentrates on two fundamental aspects of climate, namely the hydrological cycle and the characteristics of tropical cyclones. This accounts for the fact that the ability of simulating the hydrological cycle realistically is critical to understa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Glucotanycytes: a role for hypothalamic barriers in the control of metabolism by peripheral glucose' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The escalating epidemic of obesity, type-2 diabetes and metabolic syndrome represents one of the most pressing and costly biomedical challenges confronting modern society. The impaired action of peripheral hormones on brain circuits controlling feeding and energy homeostasis, also known as ""central hormone resistance"", is increasingly recognized as playing a role in the pathophysiology of these disorders. The host laboratory has raised the groundbreaking notion that tanycytes, a specific type of hypothalamic glial cells, act as ""gatekeepers"" that regulate the access of blood-borne signals to the hypothalamus, and in particular, their vesicular transport into the cerebrospinal fluid, from where they enters other metabolic-hormone-sensitive regions. The overall objective of this proposal is to further develop this highly original angle by using state-of-the-art approaches to i) gain new insights into the molecular mechanisms underlying structural changes in the tanycytic barrier in response to fluctuating concentrations of circulating glucose, and determine how these processes are altered in animal models with acquired type-2 diabetes, and ii) explore the possibility that tanycytes are involved in the shuttling of circulating glucose into the cerebrospinal fluid (CSF) and that the tanycytic expression of the NMDA receptor plays a role in this process. This research promises to shed new light on the molecular mechanisms used by the hypothalamus to integrate key peripheral signals and coordinate energy homeostasis. The results will pave the way for the development of new treatment strategies to overcome hormone resistance in human obesity and associated metabolic syndromes.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Intelligent Personalised Disease Monitoring Device: a-Doc'.

assistant: **Concept**

600m people globally suffer from autoimmune diseases such as rheumatoid arthritis (RA), psoriasis, and multiple sclerosis. The symptoms can be severe, causing intense pain and suffering for patients. The cost of RA alone for Europe is €45.3 billion p.a.A growing need: Unlike diabetes patients for example who can measure their own blood sugar levels, there is currently no method to measure disease activity quickly and accurately for autoimmune patients, non-invasively at home. Furthermore, most autoimmune diseases have unpredictable flares in disease activity despite stable medication, and the causes of such flares differ between patients and are largely unidentifiable.Our deep-tech innovation is an Artificial Intelligence approach to the Monitoring of Autoimmune Diseases at Home with a Novel Biomarker Algorithm:  Through 15 years of research in this field, the founder of Kaass Discovery, Dr Anita Kaass, has shown a key biomarker, Gonadotropin releasing hormone (GnRH), is common to several autoimmune diseases. It has been scientifically shown that GnRH levels increase with increasing disease activity. Kaass Discovery is developing a highly novel, deep tech solution to allow autoimmune disease patients to self-manage their conditions and minimize or even eliminate the symptoms of autoimmune diseases. The solution, which we call ‘a-Doc’, uses a saliva sample to indicate disease activity and provide an accurate, instantaneous value. In line with this need, it is also low cost, accurate and simple to use ensuring it is suitable for home use. The data collected from the device will be sent to the Kaass Discovery Cloud for improving the predictive analytical models, and giving an individualised meaningful result to the user on their mobile deviceThe aims of the Women TechEU pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Organic Rankine Cycle Cogeneration Plant of one-farm size using rice straw as single fuel' (POWERICE).

assistant: **Concept**

Rice straw has been treated as by-product without any economic value out of ground burning. Actually, Europe produces 3,350 Ktons/year of rice straw that can be used by co-generation plants to produce energy. Now, the time has taken its course and these spin-offs have turned to a commodity more than a choice, due to EC regulations regarding to rice cropping and competence from outside Europe, especially from Asia. However, the co-generation industry cannot produce energy when the need is below 200kWe due to technical and economical bias.POWERICE co-generation plants use rice straw as unique fuel, and will be dimensioned on a single farm basis. The deep knowledge of rice sector in Italy (EU strongest producer), and a wide expertise in supply chain logistics of FORENERGY, the applying SME (IT), will be gathered with the reputed engineering competences in straw burning by KEM (DK) and ENERTIME (FR).The project will overcome challenges of a scaling down process, justified by the booming perspectives of the European potential market. Each step of the overall process will be analysed in order to increase efficiency, namely as a simplified and robust fuel storage, reliable handling and feeding systems, simplified boiler operating conditions (pressure, temperatures, medium quality requirements), and reduction of specialized alloy metals in the boiler design to lower general costs of the heat source when using small ORC turbines. The main technical drawback of current rice power plants derived from the high silica content of ashes is overcome by an innovative method that limits burning temperature, and with a dedicated coating for inner boiler surface.Since high quality silica is the natural outcome of rice straw combustion, its value chain will be deepened in order to transform