RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mapping and modulating integrin mediated interactions', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Multicellular life depends on the effective communication between cells and their surroundings. One of the primary conduits for cellular interactions is the membrane-embedded receptor family of integrins. Integrins are crucial for several key biological processes, from blood clotting, to proper immune response. Integrin misregulation is at the heart of several diseases, such as Crohn’s disease, MS, or cancer, and integrins are targeted by several viruses as entry points. Yet, our current drugs are not capable of efficiently combating these diseases, as we do not have sufficient molecular and network level knowledge of how integrins work.The main research objective of MIMIC is to develop an original hybrid in silico/in vitro framework that allows the identification and characterization of unknown elements of integrin signaling. It will present the first such systematic large-scale effort, integrating computational modeling with state-of-the-art experimental techniques. MIMIC will provide the first structured description of integrin ligand specificity profiles, extending our current limited descriptions of extracellular integrin interactions. Thus, MIMIC will be the missing link between integrin research and recent advancements in linear motif research.The developed framework will not only enable the identification of currently unknown integrin ligands, but will also lay the foundations for innovative approaches in the development of therapeutic agents for integrin-related diseases. Building on the developed experimentally verified computational models, I will construct a novel peptide-based inhibitor design pipeline. MIMIC will provide a structural basis for currently missing immune-specific interactions in atomic detail. I will use this knowledge to design the first imm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'AWAKENING SLEEPING BEAUTIES: UNLOCKING NEW EUROPEAN BAUHAUS AND NATURE-BASED SOLUTIONS VALUES FOR A MORE SUSTAINABLE, INCLUSIVE AND RESILIENT SOCIETY' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The SLEEPING BEAUTY project aims to rejuvenate neglected urban, peri-urban, and rural spaces across Europe through the integration of Nature-based Solutions (NBS) and the core values of the New European Bauhaus (NEB). By addressing diverse climatic contexts, this initiative promotes sustainable, inclusive, and resilient communities. The project leverages NBS to enhance biodiversity, foster natural beauty, and provide multifunctional public spaces, aligning with NEB’s principles of sustainability, beauty, and inclusiveness.SLEEPING BEAUTY seeks to transform underutilized and overlooked spaces into vibrant, biodiverse areas that reconnect people with nature. This holistic, co-creative approach combines innovative design and artistic interventions, encouraging collaboration among citizens, experts, and local stakeholders. These efforts will help reshape public spaces, strengthen community ties, and foster a shared sense for caretaking of environment.By emphasizing the creative re-use and revitalization of spaces, the project will demonstrate how integrating NEB and NBS can lead to improved well-being, enhanced biodiversity, and more resilient and beautiful communities. The project’s six pilot sites will serve as showcases for replicating and scaling NBS-NEB solutions across Europe, contributing to a systemic shift in how we design, interact with, and maintain public spaces in close connection with nature and cultural heritage. The initiative promotes long-term societal transformation, focusing on strengthening human-nature relationships, cultural identity, and collective action to address pressing societal challenges like climate change.SLEEPING BEAUTY’s unique blend of artistic co-creation, sustainable spatial planning and innovation will push beyond traditional NBS appro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MULTIfunctional PersonaL EYEglass interface', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

This project seeks to develop, characterise and demonstrate a novel display interface that is fully wearable and portable for the delivery of information to users operating in multi-functional contexts. The main applications will be: vision enhancement and navigation in driving, specialised computer assisted operations (surgeons, assembly workers), office applications, entertainment, infotainment, vision enhancement for visually impaired people, etc. The system will be composed of a primary display source, a compact light-guiding system for the projection of images, a variable-transmittance optical window to allow for different background intensities (adaptive see-through), a miniaturised inertial system (based on MEMS technology) for the tracking of head position and orientation (to work in conjunction with a GPS module), a radio-frequency Rx/Tx module for the exchange of information between the interface and the base station (including master navigator, image generator), CMOS camera, speakers, microphone, rechargeable battery and driver electronics.Work description:The project has a duration of three years. The workplan is structured to account for the complexity of the project and its objectives. As the objectives include both RTD and characterisation of novel display components, and their integration into advanced information display systems (for improved performance of users under operational and temporal stress), the workplan is broken down into four work phases, and a dissemination/exploitation effort, namely:a) conceptual system design;%b) component development and testing;c) system integration;d) system assessment, functional and ergonomic field-testing;e) dissemination and exploitation of the results.During the first project phase (WP0) the consortium will des
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European regions fostering innovation for sustainable production and efficient use of woody biomass' (ROKWOOD).

assistant: **Concept**

The ROKWOOD project will support the cooperation between six European research-driven clusters in order to improve research and technological development (RTD), market uptake and to increase investments in wooden biomass production and utilisation schemes at regional level. The six participating regional clusters will be co-ordinated in order to develop a Joint Action Plan (JAP) at European level to drive economic development through research and technological development activities in the selected topics of sustainable production and efficient use of wooden biomass.Each regional research-driven cluster is represented in the ROKWOOD project by three partners respecting the triple-helix concept (business entity, research entity and local/regional authority). Apart from these partners the European Biomass Industry Association (EUBIA) has joint the consortium in order to assure a broad dissemination of project results to a broad range of stakeholders (e.g. industry, biomass producer, research organisations). All partners have been actively involved in the development, implementation, monitoring and utilisation of short rotation plantations (SRPs) for the regional production of wooden biomass. Taking into account the knowledge and experience of the partners the project has the capacity to become one main driver of innovation in the wooden biomass sector in Europe. Some of the project partners have already been involved in various common research projects in the addressed sector. However, the need for a networking structure in order to enhance this collaboration was discussed several times among the participating regions. “Regions of Knowledge” is the perfect funding scheme for further discussions and implementation of ideas the proposing clusters have developed in the last
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'NTN-SNR Proposal for Propellers Blades Bearings Design and Manufacturing' (SNRPBBEARING) under Seventh Framework.

assistant: **Objectives**

NTN-SNR is a major supplier for the propellers blade bearing. That is why NTN-SNR answers to this topic of call 12. The global strategy of the project is divided into 4 major tasks which constitute the work packages of the project (WP2 to WP5) and one work package is dedicated to the management (WP1). This project will be led according to NTN-SNR usual development process for new products or R&D projects.The goal of NTN-SNR proposal is to meet the topic manager requirements. The Propellers Blades bearings will be designed, manufactured and tested (component tests are required necessary to demonstrate the behaviour with different loads cases – TRL 5 is required ) to withstand the radial load of the propeller blade load in operating condition due centrifugal forces and unbalance loads, to withstand axial and tangential loads due to aerodynamic forces on the blade and to withstand to the high temperatures.The global coordination of the project will be of the responsibility of the aerospace R&D project leader. The aerospace R&D project leader will be the focal point for the topic manager. He will be responsible for the time schedule and for the success of the project.The bearing designs will be performed by NTN-SNR Aerospace design office using its knowledge and its experience on this type of application and so innovative solutions will be implemented in these bearings.The bearings will be manufactured according to the NTN-SNR quality process, the certified standard process and the flight test safety requirements. The industrial validation report will be delivered with the bearings.To reduce the risks linked to the chosen concepts, several specific tests will be performed by the NTN-SNR test centre and by the material laboratory and by specialised vibratory.Due to current a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Sulphur, Carbon, and re-Oxidation Tolerant Anodes and Anode Supports for Solid Oxide Fuel Cells'.

assistant: **Innovation**

The project will demonstrate a new full ceramic SOFC cell with superior robustness as regards to sulphur tolerance, carbon deposition (coking) and re-oxidation (redox resistance). Such a cell mitigates three major failure mechanisms which today have to be addressed at the system level. Having a more robust cell will thus enable the system to be simplified, something of particular importance for small systems, e.g. for combined heat and power (CHP). The new ceramic based cell will be produced by integrating a new, very promising class of materials, strontium titanates, into existing, proven SOFC cell designs. Cost effective and up-scalable processes will be developed for the fabrication of supports and cells. In an iterative process the cell performance at defined tolerance levels will subsequently be improved by adjustments of the fabrication on full cell level according to identified failure mechanisms. Cells with matching performance but improved sulphur, coling and re-oxidation tolerance compared to state-of-the-art Ni-cermet materials will finally be demonstrated in a real system environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Kinematic Identification of Developmental Disorders'.

assistant: **Concept**

The high levels of deprivation and multi-ethnic nature of Bradford’s population make it an ideal setting in which start a developmental disorders epidemiologic study.  Bradford is the 6th largest metropolitan borough in England with a population of ~ 500,000 and includes some of the most deprived areas in the UK. Problems which begin in early childhood often translate into lifelong inequalities in health and wellbeing. Sixty per cent of babies born in Bradford are born into the poorest 20% of the population of England and Wales based on the index of multiple deprivation (IMD). Therefore being able to deliver potentially beneficial interventions from as early as possible in a child’s life is vital to reduce inequalities. Bradford therefore also offers an invaluable opportunity to test intervention therapies in a manner which is sensitive to the wider issue of health inequalities. Early identification of developmental disorders will be effective in engaging and helping those individuals which are expected to be in most need of intervention and yet also some of the most difficult to reach. The main aims of the project are: 1. To identify a selection of children who may have Developmental disorders. 2. To profile in detail these children to identify exactly their difficulties. 3. To ascertain how these difficulties influence activities of daily living or academic performance. 4. To elaborate an individual intervention plan for each child including recommendation for parents/teachers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Science in Europe 2020' to be submitted under Seventh Framework.

assistant: **Abstract**

The successive Eurobarometer studies have confirmed that Television was the main source of scientific information for the European Public. The 2007 Work Programme specifically included measures to support the ""promotion of science by audiovisual means via European coproductions and the circulation of science programmes"". The project 'Science in Europe 2020' aims to enhance the knowledge and the awareness of scientific research in Europe in some key fields by improving the presence of science on European screens and to contribute to a better understanding between scientists and science communicators and the public.  As the leading world-wide broadcasting organisation, the European Broadcasting Union (EBU) will put at the disposal of this project its unique position on the audiovisual market. It will manage the project from its headquarters in Geneva, Switzerland. To achieve increased presence of scientific content on TV screens in Europe, the project will focus on helping independent European TV producers producing content in the field of science. One of the main objective of the project is the investment of EU funding in TV productions in that field. To that end, a certain number of productions have been identified. The EBU will bring its support to these productions by reinvesting a part of the awarded EU Grant in those TV Programmes. And, in cooperating with those producers the EBU will bring these productions to the attention of the public at large. To ensure a transparent information of the public, the TV productions will be handled independently by European producers under their sole editorial and financial control. The independent producers will be regarded as third parties in charge of a part of the project. In addition, the EBU manages on a regular basis a cer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dynamic control of Gaussian morphing structures via embedded fluidic networks' (DynaMorph).

assistant: **Concept**

Transforming a flat plate into a doubly curved shell is not possible without distorting in-plane distances, as stated by Gauss in his seminal theorem. In natural morphogenesis, this strong geometrical constraint is overcome by differential growth in the tissues, which induces mechanical stresses and thus the buckling in a rich variety of shapes. Over the last decade, emerging approaches have embraced this paradigm to develop bioinspired synthetic responsive materials with in-plane distortions, and hence shape-morphing capabilities. However, despite rapid developments, current efforts primarily focus on programming the final equilibrium shape, overseeing the dynamical trajectory of the transformation but also the mechanics of the morphed structure. As a result, exciting biomedical applications perspective in minimally invasive surgery, rehabilitation and soft robotics remain so far elusive.Here, I aim to develop structures in which the shape, but also the mechanics and the dynamical deformation trajectory may be programmed in time. To do so, I propose to develop hybrid elastic plates embedding a network of fluid-filled cavities. First, I will generalise design principles to create unit cells that dispose of all six deformation modes (both in-plane and out-of-plane) when pressurized. Assembling such cells will enable univocal shape selection but also internal degrees of freedom to control the frustrated mechanics. Then, I will unravel the coupling between fluid viscosity and cavity geometry to spatially control the homogenized viscoelastic property of the material. The subsequent timescales will be finally used to program the dynamical deformation trajectory of the structure when submitted to a mechanical or fluidic load.Taken together, I propose to develop new experiment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Role of hepatitis C virus (HCV) transactivating proteins in the pathogenesis of HCV-induced liver lesions and hepatocellular carcinoma (HCC)' (HCV).

assistant: **Innovation**

HCV infection affects more than 170 million people worldwide and is becoming the first cause of liver transplantation and primary liver cancer in industrialized countries. Whether HCV induces liver cancers through the cirrhosis it causes, or bears intrinsic carcinogenetic properties is debated, and the molecular mechanisms underlying HCV-related hepatocarcinogenesis remain unknown. The hosting laboratory (INSERM U635) has recently shown that quasispecies variants of HCV NS5A protein bear significantly different transactivating properties, according to their amino acid sequence. Such properties could play a role in the early steps of HCV-related hepatocarcinogenesis. We hypothesize that both the core and NS5A transactivating properties play a role in the triggering of early carcinogenetic events in HCV infection and that this role is modulated by the natural variability of these proteins. Intracellular production, even in low amounts, of proteins with strong transactivating properties could interact with cellular mechanisms and have transforming properties on hepatocytes, which may ultimately lead to HCC development.In this project, we will: 1) characterize the natural genetic variability of core and NS5A variants and its functional impact on their transcription al activities in vitro; 2) study the consequences of HCV protein repertoire expression, ex vivo and in vivo, according to the transcriptional activity of core and NS5A protein variants, and 3) understand the role of transactivation properties carried by HCV proteins in the sequence of HCV-related liver pathogenesis. The originality of our project resides in two key fundamentals: 1) the use of HCV sequences directly cloned from chronically infected patients with well characterized hepatic consequences of HCV infec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Electrowetting Dynamics' to be submitted under Seventh Framework.

assistant: **Abstract**

This proposal is concerned with electrowetting, which is a surface wetting phenomenon resulting from the electrical control of the surface tension properties on application of an electric potential. In recent years, the control of aqueous droplets on dielectrically insulated has become a hot topic. On the one hand, there are applications of electrowetting in electrical displays, auto-focus liquid lenses for mobile phones and video-speed smart paper. On the other hand, it offers many exciting applications for microfluidic systems for lab-on-a-chip devices to move, split, merge, and mix liquid droplets. The objective of the proposed research is to improve the performance of electrowetting in microfluidic systems for application to the pipe based bioreactor system that has been developed at the host institute. This improved performance is to be achieved by improved material choice for insulating and hydrophobic layers and a deeper study of how the interfacial properties of various materials affect the electrowetting dynamics.