RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bioartificial Pancreas refinement' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The proposed project aims at making a substantial contribution to the success of bioartificial pancreases and thus to a cure for type 1 diabetes (T1D). The latter is an autoimmune disease that destroys pancreatic beta cells which are responsible for insulin production. Mostly it strikes at a young age. Patients depend on frequent insulin injections for the rest of their life. Despite these burdensome injections, acute and long-term complications are frequent and often severe. Beta cell transplantation represents the only means of restoring physiological blood glucose control in T1D patients. But it has been hampered by a shortage of donor organs and the detrimental effects of immune suppressive medication. The latter can be circumvented by encapsulation of beta cells prior to implantation. Efforts to translate this concept of the so-called bioartificial pancreas into a clinical product have proven difficult due to poor survival of the transplanted beta cells. The current proposal aims at (1) introducing a novel type of surrogate beta cell which is much more robust than native islet cells and (2) establishing the use of an encapsulation material with superior biocompatibility. These two advancements combined are likely to improve survival and long-term functionality of the bioartificial pancreas.The researcher masterminding this project has spent the last 5 years in a bioencapsulation company in Asia’s biotech hub Singapore, most recently in the role as Chief Scientist.The host organisation, the Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), is a centre of excellence for basic and clinical research on vascular diseases and diabetes. With the researcher on board, the VIVIT is currently establishing its cell encapsulation capability and applying it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A European standardization framework for data integration and data-driven in silico models for personalized medicine'.

assistant: **Objectives**

The capacity to generate data in Life Sciences and health research with modern omics and imaging technologies has increased many orders of magnitude in the last decade. In combination with patient/personal derived data such as electronic health records, patient registries and -databases, as well as life style information this Big Data holds an immense potential for clinical applications, especially for in silico personalized medicine approaches. However, and despite the ever progressing technological advances in producing data, the exploitation of Big Data information to generate new knowledge for medical benefits, while guaranteeing data privacy and security, is lacking behind its full potential. A reason for this obstacle is the inherent heterogeneity of Big Data and the lack of broadly accepted standards that allow interoperable integration of heterogeneous health data to perform analysis and interpretation for predictive in silico modelling approaches in health research such as personalized medicine. Further obstacles are legal issues surrounding the use of personal data. To overcome these obstacles, we will establish a pan-European Expert forum with two main objectives: (i) to assess and evaluate national standardization strategies for interoperable health data integration (such as omics-, disease-focused-, clinical-/treatment- or healthcare- and socioeconomic-/lifestyle-data) as well as data-driven in silico modelling approaches and (ii) to harmonize and develop universal (cross-border) standards as well as recommendations for in silico methodologies applied in personalized medicine approaches. This pan-European Expert Forum —the EU-STANDS4PM consortium— has the overarching aim to bundle transnational standardization guidelines for in silico methodologies in trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From PalaeoProteomics to Population Genetics' under Horizon Europe.

assistant: **Concept**

The study of ancient biomolecules is a captivating field that allows us to delve directly into the past and unravel the demographic history of human populations and their evolution. Through the study of ancient biomolecules such as proteins and DNA, researchers have unearthed new hominin species and the geographical distribution of humans and their relatives in the distant past. However, the recovery of ancient DNA is often limited by environmental factors that lead to its degradation. In contrast, skeletal proteins have been shown to endure for longer periods than DNA and in a wider range of environmental conditions. This has led to recent breakthroughs in the analysis of ancient proteomes(palaeoproteomics) through protein mass spectrometry methods, enabling us to address phylogenetic questions in human evolution based on ancient protein evidence. Such studies have been largely restricted to phylogenetic hypothesis testing so far. In contrast, ProPGen aims to evaluate the feasibility of population genetic analyses based on palaeoproteomic data. I will use existing human and archaic hominin genome data to create a reference panel of proteome sequence variation among globally distributed human populations and interrogate this dataset to explore whether population genetic analysis with proteomics information reveals known patterns of population genetic relationships. Next, I will leverage this dataset in the context of recent (Mediaeval humans from the Netherlands) and Pleistocene European human proteomes, testing existing hypotheses on the population genetic relationships of the studied individuals. The anticipated outcome is a reference panel of proteomic information from bone and teeth, and the assessment of population genetic analyses using proteomic data. This will e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Elucidating the mechanisms, heterogeneity and role of epigenetic topological alterations in cancer' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cancer genomics has revolutionized cancer research by systematic mapping of oncogenic genetic alterations of genes, yet oncogenic epigenetic alterations of regulatory elements away from genes remain elusive. I recently demonstrated that aberrant DNA methylation of CTCF binding sites perturbs chromosomal topology in IDH-mutant glioma and SDH-deficient gastrointestinal stromal tumors (GISTs). Loss of CTCF binding at the boundary between two topologically associating domains disrupts their insulation, leading to oncogene activation. This groundbreaking model links metabolic, epigenetic and topological alterations and demonstrates that they can drive oncogenesis. Aberrant DNA methylation is common in many tumors and therefore epigenetic CTCF disruption may play a role in other cancers, but this has not been studied to date.Prompted by my findings, recent advances in genome-wide characterization methods and newly available large-scale data, I now propose to systematically uncover the rules of regulation of DNA methylation at CTCF binding sites, and how its disruption in cancer leads to epigenetic heterogeneity and drives oncogenesis. To achieve that, we will develop new statistical models to systematically uncover the rules of regulation of DNA methylation at CTCF binding sites and its impact on topology (Aim 1); uncover mechanisms of epigenetic topological alterations and their role in cancer (Aim 2); and develop computational tools to study intratumor epigenetic heterogeneity to investigate the interplay between different subclones (Aim 3). Taken together, this research program will facilitate a systematic understanding of epigenetic topological alterations and their role in cancer. These are critical goals for the field in order to understand the events that drive cancer,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'BOOSting excellence in environmental EPIgenetics' (EPIBOOST) targeting Horizon Europe.

assistant: **Abstract**

The EPIBOOST project joins a widening partner and two internationally-leading partners that will steer a solid capacitation strategy towards tackling the challenges to the recently proposed uptake of epigenomics by Environmental Assessment frameworks. Capacitation activities cover for 5 specific objectives. The 1st is to optimize research protocols, enhancing the practical skills and research profile of the Widening partner for the development of excellent Science in the field of environmental epigenetics. This constitutes the nurturing stage, where we will be twinning (exchanges and training sessions) under an overall philosophy of learning- and advancing-by-doing allowed by a preparatory research project, which will build knowledge on the suitability of DNA methylation signatures as informative biomarkers of environmental contamination and effects. The 2nd objective is focused on the seeding of the talent that will sustain the European critical mass at the best world-class standards in the field, through the organization of several training events (advanced courses, summer schools and short courses in scientific meetings) targeting young EU researchers. The 3rd and 4th objectives regard the absolute need of a capacitated science management and administrative support to effectively grow world-class research in the field; these will be tackled through an immersive training programme focusing key core facilities (ethics & animal housing; sequencing), managers exchange for on-site training, professional training and real-time funding application preparation. The fifth addresses network growing and will be achieved through a systematic strategy for involving international flagship experts in capacitation activities and stakeholders in the project, which will strengthen the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Launching the Mashcream Lifestyle With the  In-Home Cool Plate Ice Cream Maker' (Mashcream), addressing dissemination and exploitation.

assistant: **Impact**

The consumption of ice cream has increased by 21% and is expected to grow to €30 billion by 2024 . At the same time, millennials tend towards cooking at home and making home-made ice cream . However, our society is overweight, which affects between 30-70% and more than 60% of children, and obese, which affects 10-30% of all adults . Plus, we are wasting a lot of food - €1 trillion are wasted or thrown away each year. Furthermore, the energy consumption for producing ice cream is very high.Mashcream is an innovative ice cream production concept based on an on-demand cold plate. We are working on bringing this innovation into every home to become the “Nespresso of ice cream”. Consumers will purchase a Mashream ice cream maker that comes with a scoop and measuring cup and then order the Mashcream ice cream base. We have opened 13 shop in shop workstations in 2018 and have participated in over 10 seasonal events with our street food formula. Mashcream is a quality ice-cream: natural, healthy, gluten-free, organic and 100% Italian that consumers will be able to make themselves.Mashcream is the ideal platform for social cooking. The European ice cream market is expected to grow to over €30 million by 2024 . Assuming that every tenth household has an ice cream maker and that it needs to be exchanged every 5 years, our SOM in Europe would be €442.6 million.The in-home solution (35x35cm) will be presented as a household appliance to be placed on the consumer market and purchased with a kit of balanced products at room temperature, thus eliminating the cold chain. We aim at a retail price for €100. We have three business models: Shop in shop, street food and store.Mashcream can help the EU achieve reduce food waste and the carbon footprint from food. In the EU alone, around 88 mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'ULTRA-FAST CHEMICAL ANALYSIS IMAGING WITH RAMAN'.

assistant: **Concept**

Most diseases including cancers, viral infections, neurodegenerative conditions, cardiovascular and musculoskeletal disorders, all originate from a molecular level disruption of the biological cell lifecycle. Each year the cost to the EU is ca. 1.9 million lives and ca. €200 billion in health care, informal care and productivity loss for cancers alone. Current live cell imaging tools can only provide a limited view of the in vivo and in vitro microenvironments where diseases originate and grow. The result is a gap in our understanding of the biochemical cellular makeup and how their disturbance leads to disease. By increasing accuracy and speed of imaging and analysis, the gap can be closed allowing novel medical treatments and diagnostics tailored to patients’ specific conditions. uCAIR brings successful R&D photonics SMEs, research laboratories in optics and cell biology, and world-leading microscopists and clinicians to create an innovative, versatile, practical multimodal photonics platform that will enhance and speed up the way cells are examined by scientists and healthcare professionals. uCAIR will achieve breakthrough results by developing a laser platform that inventively combines non-linear optical fibers, optronics, wide-band coherent Raman and artificial intelligence technologies to image at video rates and track cells and biological tissues with augmented chemometric digitalisation. The new coherent light sources will be suitable for fundamental research microscopes and microfluidic channels but also in medical imaging instruments, encompassing a value chain for new biomarker discoveries and translation into medical endoscopy, for example during cystoscopy and resection of bladder cancer. Technology progression to TRL 6 will allow first mover advantage with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'EUROpean network of TRANS-national collaborative RTD for SME's projects in the field of BIOtechnology'' in the context of a Sixth Framework call.

assistant: **Objectives**

Within the world-wide competition, European Biotechnology SME's are facing a challenge to gain a critical size on the market in terms of RTD project portfolio, capitalisation, and scientific and managerial excellence. Currently, national RTD programmes for biotechnology SME's and public research laboratories do exist in many EU member states. However, trans-national funding within the national/regional programmes is not common. In the European Community, trans-national public-private partnerships could achieve synergy effects, reduce risks and costs in R&D projects and thus gain benefits in competitiveness. The aim of the EUROTRANS-BIO project is to commit ministries and government agencies from Member States (Austria, Finland, France, Germany, the Netherlands, Spain/Basque) in the design and the implementation of a truly integrated trans-national RTD programme. Such an activity will develop best practices, establish cross-border partnerships between SME's and/or public research laboratories, strengthen European efforts to achieve sustainable development and disseminate best practices. The management of the project is led by a Network Steering Committee composed of high level programme and policy representatives. The consortium will make all its efforts for the incoming of new Member States that where not ready to join during the implementation of the proposal. After 48 months duration the EUROTRANS-BIO project, structured into five work packages (exchange of information, practices, strategic activities, implementation of joint activities and transnational call for projects), could lead to a truly integrated programme in the area of biotechnology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enabling Visual IoT Applications with Advanced Network Coding Algorithms' (ENVISION).

assistant: **Innovation**

The latest advances and integration of several key technologies such as wireless communications, low-power sensing, embedded systems, Internet protocols and cloud computing, have enabled the emergence of the Internet of Things (IoT) paradigm. However, the ever-growing deployment of the visual sensing applications within IoT deployments is expected to strain the network and cloud infrastructures used to deliver and store massive amounts of visual data. To partly address these challenges, prototypes of neuromorphic visual sensors, a.k.a. dynamic vision sensors (DVS), have been produced in the last two years. Instead of the conventional raster scan of video cameras, DVS devices record pixel coordinates and timestamps of reflectance events in an asynchronous manner, thereby offering substantial improvements in sampling speed and power consumption. ENVISION argues that, in order to fully exploit the advantages of neuromorphic sensing for IoT applications, such devices should be coupled with appropriate transmission and storage mechanisms that would take advantage of the visual data properties to achieve even higher bandwidth, power and storage efficiency. The ENVISION project aims at developing such data-driven delivery and storage algorithms based on advanced network coding techniques for data acquired by both conventional frame-based video cameras and DVS devices. Specifically, ENVISION is pursuing three interconnected  research objectives: (i) designing advanced content-driven network codes for efficient transmission of the visual content captured by neuromorphic and conventional visual sensors  to the cloud service under bandwidth and power constraints, (ii) developing novel content-aware network codes for storage of the visual content under the cost-performance optimisa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Biologically-inspired autonomic networks and services' (BIONETS) under Sixth Framework.

assistant: **Objectives**

The motivation for BIONETS comes from emerging trends towards pervasive computing and communication environments, where myriads of networked devices with very different features will enhance our five senses, our communication and tool manipulation capabilities. The complexity of such environments will not be far from that of biological organisms, ecosystems, and socio-economic communities.Traditional communication approaches are ineffective in this context, since they fail to address several new features: a huge number of nodes including low-cost sensing/identifying devices, a wide heterogeneity in node capabilities, high node mobility, the management complexity, the possibility of exploiting spare node resources.BIONETS aims at a novel approach able to address these challenges. Nature and society exhibit many instances of systems in which large populations are able to reach efficient equilibrium states and to develop effective collaboration and survival strategies, able to work in the absence of central control and to exploit local interactions. We seek inspiration from these systems to provide a fully integrated network and service environment that scales to large amounts of heterogeneous devices, and that is able to adapt and evolve in an autonomic way.BIONETS overcomes device heterogeneity and achieves scalability via an autonomic and localized peer-to-peer communication paradigm. Services in BIONETS are also autonomic, and evolve to adapt to the surrounding environment, like living organisms evolve by natural selection. Biologically-inspired concepts permeate the network and its services, blending them together, so that the network moulds itself to the services it runs, and services, in turn, become a mirror image of the social networks of users they serve. This ne