RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Screening of inFlammation to enable personalized Medicine' (SciFiMed).

assistant: **Innovation**

This transdisciplinary project will combine fundamental immunological research with novel nanomaterial-based biosensor development translated into proof-of-principle diagnostics to revolutionize doctors ability to diagnose and treat severe diseases plaguing millions of Europeans. Impaired defence against infections, incurable renal, eye and autoimmune diseases represent a huge burden on human health and consequently cost our society not only personal suffering but also hundreds of billions of Euros p.a.. All of these diseases share an association with a dysregulation of the complement system, a major effector of the innate immune system. There still is a huge discrepancy between what we know and what we need to know about the complement systems role in these diseases in order to prevent, diagnose and treat them appropriately, effectively, and efficiently . Complement factor H (FH) and FH-related (FHR) proteins are strongly associated with these systemic and organ-specific pathologies. In contrast to FH, the function of the remaining six highly homologous FHR proteins is mostly unknown and, hence, their role in the different disease-specific pathogenic mechanisms remain elusive. Our EU consortium (8 partners from 4 countries) will unravel the mysteries of the FH-protein familys contributions to diseases. Then, via an ambitious and transdisciplinary fundamental science-to-technology transfer, a proof-of-principle for a multiplex detection system will be developed to simultaneously quantify and analyse the functional activity of all seven FH-protein family members in patient samples  on site, putting diagnostic technology directly into physicians hands. In the future, this high-impact project propels immunological research in Europe, enables new product development of bioa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Effective Interactions and correlations of ring polymers'.

assistant: **Concept**

Understanding the Physics of modern materials on a fundamental level is a key ingredient in the quest to develop novel materials with desired, tailored properties. In this sense, polymers, are in enormous interest nowadays, due to their numerous applications in biology and industry. The development of experimental techniques, such as atomic force microscopy (AFM) and optical tweezers, allow us to manipulate the topology of macromolecules, including the most common biological polymer, DNA. Topological constraints on the polymers are an universal feature that can influence the properties of individual macromolecules and solutions of the same. Their analytical consideration is hindered, i.a., by the difficulty to include topological constraints in the Hamiltonian. Computer simulations offer an alternative. Previous work has focused, mainly, in knotting probabilities with lattice models in three and two dimensional models. We propose the approach of performing computer simulations in the continuum, to investigate the structural properties of ring polymer solutions with topological constraints and predict the correlations, structure and thermodynamics of the system. To accomplish this project, we will develop suitable coarse-grained techniques and advanced programming to sample the properties of ring polymer solutions in ways that respect the topological constraints. Further, we propose a novel development of the blob technique for topological constraints in dilute and semidilute solutions. The goals of the proposal is, on the one hand, to calculate accurate effective interaction potentials acting between suitably chosen coarse-grained degrees of freedom of the rings, greatly facilitating thereby their study, and to study the effects of knots on the quantitative characterist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Feasibility study for Titan Fire System S.L.' under Horizon 2020.

assistant: **Concept**

The number of fires per inhabitant has increased over a 250% in the world from 2008 to 2015. Only in 2015, the number of deaths almost reached the 45,000 people in over 3.5 million of fires attended. Infrastructures and vehicles fires account for over a 50% of the total. The economic cost of fire is also relevant. Only in the US, the total cost of fire in 2011 was estimated at $329 billion, or roughly 2.1 percent of U.S. GDP. This cost represents a 34% increase over 1980.Prevention measures for fires are based on devices like CO2 or temperature detectors, alarms and mechanical items likeextinguishers, firefighting fixtures or pumping groups. These mechanical components are subject to visual inspections from time to time which in the mid-term is a major danger. These old-fashioned procedures for inspection and maintenance may cause major damages in the case of the fire, and have a high-cost in terms of money but also lives. A simple malfunction of the mechanical items can quickly turn fatal.Titan Fire System (TFS) has created and patented a technology to better monitor, analyse and prevent fires is all sorts offacilities, with a special focus in critical infrastructure. This technology will disrupt the market of fire prevention systems as they are now conceived worldwide.TFS is comprised by a (1) Patented digital manometer or smart manometer; (2) Patented module to receive/transmit thesignals from/to the manometers to/from the alarm receiving system (3) Software including a desktop application and an app; (4) Titan cloud to analyse and alert about incidences.TFS will allow to improve safety against fires, to significantly reduce costs in a security installation and to modernise a very traditional sector.TFS has already signed their first agreement with a distributor in S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Using cell-cell interactions to unlock new cancer treatments: Forcing neural crest tumors back onto the developmental path' in the context of a Horizon 2020 call.

assistant: **Objectives**

The interactions between tumor and its microenvironment are often critical to uncovering the mechanisms of tumor survival. A striking example is the recent success of immunotherapy approaches that expose tumor cells to immune attack by disrupting a specific interaction between the tumor and infiltrating lymphocytes.  The tumor can also repress immune response by inducing complex interactions among dozens of immune and stromal cell types that typically make up tumor microenvironment, however those remain largely uncharacterized as we currently lack systematic approaches to uncover relevant cell-cell interactions. The alternative to killing tumor cells, either directly or through immune system, is to force them to differentiate. Such strategy is particularly promising for tumors arising due to failure of progenitor populations to follow proper differentiation cascade. Here as well, the progress has been limited by lack of understanding of specific intercellular signals that that are disrupted in tumorigenesis. We propose a systematic approach for characterizing cell-cell interactions in complex microenvironments through joint analysis of spatially-resolved and disassociated single-cell transcriptomics. We will apply it to identify inter-cellular signals and pathways that can push tumors of neural crest origin, including as pheochromocytoma (PCC), paraganglioma (PGL) and neuroblastoma (NB), towards terminal differentiation. Building on our expertise with neural crest development, we will use single-cell profiling to map individual tumor cells onto developmental trajectory of neural crest differentiation. Spatial transcriptomics analysis will then be used to identify the sources and nature of microenvironment signals that channel neural crest differentiation during normal d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Yeasts as protein factories: control of host physiology and exploration of novel resources' under Fourth Framework.

assistant: **Concept**

Microbial systems are particularly suited for the production of recombinant proteins. Among them yeasts have often been successful where bacterial systems failed. Whilst many attempts have been made with the classical baker's yeast Saccharomyces cerevisiae, the most significant achievements in the production of mammalian proteins have been obtained by the use of a few non-Saccharomyces yeasts. Especially, the dairy yeast Kluyveromyces lactis has been shown to be capable of grams-perlitre scale production. The particularity of this proposal is to exploit the natural genetic reservoir present in the large variety of yeast species. Two approaches are taken: (1) Model systems. Two established systems to which advanced genetic analysis can be applied, namely, Kluyveromyces lactis and Yarrowia lipolytica, will be used to examine the host parameters that determine the performance of protein production. At present, the control of host conditions, rather than further manipulation of individual gene expression cassettes, is considered to be determinant to improve the production process. The host parameters concern the provision of substrates (carbon and energy metabolism), the protein synthesising process itself (transcription and translation) and the product sorting (protein traffic and secretion). These parameters will be examined under the stress conditions created by the forced synthesis of heterologous proteins. The proposal will include extensive fermentor-level studies. The project is expected to strengthen the leading position of the EC in this field established through the successive biotehnology programmes. (2) Development of new hosts and novel genetic resources. Parallel to the studies on model organismes, new host systems will be explored in two ways. One is the use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of an it based sytem for the design of the orienting part of vibratory bowl feeders for industrial applications' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Proposal objective is to develop a CAD system for the design of the orienting part of vibratory bowl feeders for industrial applications. Vibratory bowl feeders are currently the chief means for the supply of small and medium sized components to automated machines, robotic assembly lines, packaging machines, etc., its main purpose is to position and orient components, so that they can be easily picked up by the machines. No automated design methodology exists for the development of such systems, which are currently developed through manual craftmanship and rule of thumb approaches, with heavy consequences for their reliability and the reliability of the shole automated plant. A CAD system, shose basic feasibility has already been established would have sustantial benefits for a large sector of SMEs devoted to the manufacturing of these components, as well as for the overall reliability of automated manufacturing systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Minimalist multipurpose ATP-binding cassette transporters' (ABCTRANSPORT).

assistant: **Concept**

Many Gram-positive (pathogenic) bacteria are dependent on the uptake of vitamins from the environment or from the infected host. We have recently discovered the long-elusive family of membrane protein complexes catalyzing such transport. The vitamin transporters have an unprecedented modular architecture consisting of a single multipurpose energizing module (the Energy Coupling Factor, ECF) and multiple exchangeable membrane proteins responsible for substrate recognition (S-components). The S-components have characteristics of ion-gradient driven transporters (secondary active transporters), whereas the energizing modules are related to ATP-binding cassette (ABC) transporters (primary active transporters).The aim of the proposal is threefold: First, we will address the question how properties of primary and secondary transporters are combined in ECF transporters to obtain a novel transport mechanism. Second, we will study the fundamental and unresolved question how protein-protein recognition takes place in the hydrophobic environment of the lipid bilayer. The modular nature of the ECF proteins offers a natural system to study the driving forces used for membrane protein interaction. Third, we will assess whether the ECF transport systems could become targets for antibacterial drugs. ECF transporters are found exclusively in prokaryotes, and their activity is often essential for viability of Gram-positive pathogens. Thus they could turn out to be an Achilles’ heel for the organisms.Structural and mechanistic studies (X-ray crystallography, microscopy, spectroscopy and biochemistry) will reveal how the different transport modes are combined in a single protein complex, how transport is energized and catalyzed, and how protein-protein recognition takes place. Microbiologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Experimental measurement of the direct partitioning of peptides into lipid bilayers' (2007-2013).

assistant: **Concept**

The transfer of peptide segments into the lipid bilayer to form stable transmembrane helices is the crucial first step in membrane protein folding and assembly. However, the mechanisms that drive this process are not fully understood. A recent experimental assay has measured the insertion of designed peptide sequences into the endoplasmic reticulum membrane via the cellular translocon machinery. This has provided the first quantitative estimate of the translocon-to-membrane transfer free energy of polypeptide segments. However, no suitable experimental setup currently exists that allows the direct measurement of the free energy change involved in transferring peptides from water into lipid bilayers. This is because peptides that are hydrophobic enough to insert into membranes generally aggregate in solution. I propose an experimental peptide setup that directly measures the water to bilayer partitioning of a series of designed peptides that do not have this problem. These will be derived by minor re-engineering of pHLIP, a peptide based on helix C of bacteriorhodopsin. This peptide has a set of unique properties that make it ideal for the proposed study. It is soluble at neutral pH and spontaneously inserts into lipid bilayers when the pH is lowered. Remarkably, the peptide partitions as a monomer, without disrupting the bilayer, and has been shown not to aggregate either in solution or inside the bilayer. For theoreticians the proposed direct measurements are highly desirable, since they allow the calibration of current computer simulation models under identical conditions. Recent advances in algorithms and computer hardware have enabled fully converged simulations of the adsorption, folding and insertion of peptides into lipid bilayers. These studies have exposed stri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced Studies in Transfusion Epidemiology: Using ‘Big Data’ to safeguard the blood supply of the future', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The lifetime risk of receiving a transfusion is almost 20%, meaning that close to 100 million EU citizens will receive a transfusion at some point in their lives. Consequently, the issue of blood transfusion safety—in a wide sense—are highly relevant for population health. It is therefore disconcerting that blood safety is often narrowly defined, focusing almost exclusively on the elimination of known transfusion-transmitted disease, ignoring donor health and failing to consider unconventional pathogens. In this comprehensive research program, proposing a series of Advanced Studies in Transfusion Epidemiology, I will lead research within four distinct work packages, first creating a nationwide vein-to-vein database, with detailed data on blood donors and transfused patients in Sweden between 1968 and 2023, linked to detailed outcomes registers, and then making a version of this database publicly available through anonymization. We will then exploit this database in a series of applied studies divided into three work packages. In the first of these, we will conduct a careful, hypothesis-based investigation where we follow-up a previous publication from my research group, showing possible transfusion transmission of an agent causing intracerebral hemorrhage, seeking to establish the etiology of these hemorrhages, and testing whether it might have been driven by transmission of amyloid β. In the second work package we will perform a series of studies of blood donor health, investigating aspects on donor health behavior, short term risks of donating blood, and the risks of negative intergenerational effects from the iron-depletion suffered by many female blood donors. Lastly, we will perform a comprehensive, phenome-wide study where we search for unknown transfusion-transmi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Coherence of Spins in Semiconductor Nanostructures' (COSPSENA) under Seventh Framework.

assistant: **Objectives**

Macroscopic control of quantum states is a major theme in much of modern physics because quantum coherence enables study of fundamental physics and has promising applications for quantum information processing. The potential significance of quantum computing is recognized well beyond the physics community. For electron spins in GaAs quantum dots, it has become clear that decoherence caused by interactions with the nuclear spins is a major challenge.   We propose to investigate and reduce hyperfine induced decoherence with two complementary approaches: nuclear spin state narrowing and nuclear spin polarization. We propose a new projective state narrowing technique: a large, Coulomb blockaded dot measures the qubit nuclear ensemble, resulting in enhanced spin coherence times. Further, mediated by an interacting 2D electron gas via hyperfine interaction, a low temperature nuclear ferromagnetic spin state was predicted, which we propose to investigate using a quantum point contact as a nuclear polarization detector.   Estimates indicate that the nuclear ferromagnetic transition occurs in the sub-Millikelvin range, well below already hard to reach temperatures around 10 mK. However, the exciting combination of interacting electron and nuclear spin physics as well as applications in spin qubits give ample incentive to strive for sub-Millikelvin temperatures in nanostructures. We propose to build a novel type of nuclear demagnetization refrigerator aiming to reach electron temperatures of 0.1 mK in semiconductor nanostructures.   This interdisciplinary project combines Microkelvin and nanophysics, going well beyond the status quo. It is a challenging project that could be the beginning of a new era of coherent spin physics with unprecedented quantum control. This project requi