RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cellular determinants of neuronal plasticity  on the level of single synapses in vivo' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The search for the fundamental mechanisms of learning and experience-dependent memory formation in the brain has long been a central quest in neuroscience. The neocortex is a particularly relevant region for plasticity because it is involved in sensory, motor, and cognitive tasks with strong learning components. However, despite many years of intensive research our knowledge of the neuronal mechanisms of plasticity on the level of single synapses in the intact living brain is still very limited.Here I propose the use of cutting edge technology, including the ultrasensitive LOTOS procedure of in vivo two-photon calcium imaging that was developed in our laboratory, to investigate for the first time the functional properties and the plasticity of signal synapses in auditory cortical pyramidal neurons of layers 2/3, 4 and 5 in vivo. For the study of the cellular determinants of synaptic plasticity we will focus on an associative learning paradigm underlying cued fear conditioning. Importantly, this paradigm can be rapidly and effectively induced not only in awake, but also in anesthetized animals and is therefore ideally suited for these studies. In addition to a comprehensive analysis of wild type animals, we will perform experiments in mouse models of Alzheimer’s disease (AD), aiming to identify the cellular cause of the devastating impairment of memory formation observed in patients suffering from AD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Model studies on radical induced dna cleavage associated with the c-1' position' (1994-1998).

assistant: **Innovation**

Currently, there has been considerable interest in the mechanisms associated with radical-induced DNA cleavage. Apart from the established intermediacy of radicals in the C4' and C-5' positions of the sugar backbone, there has been substantial experimental evidence that C-l' radicals are also intermediates in the reaction between neocarzinostatin and double stranded DNA containing dAGC sequences and also in the reaction of bleomycin with oligonucleotides modified with a single ribo or arabino nucleoside. The goals of the proposed research will be to prepare a number of modified nucleosides and oligonucleotides, with modifications that can generate specifically a single C-1' radical species and study its degradation under a variety of condiiions. Moreover, we plan to design a second set of modifications which can specifically trap an in vitro generated C-1' radical species, this being either a carbon centered or oxygen radical.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'General overall validation for ATM' under Fourth Framework.

assistant: **Concept**

With respect to the overal ATM system validation the GENOVA project, starting from an assessment of thepotential scenarios for ATM system evolution, will define a generic approach to the ATM validation process with the description of the validation activities, their inputs and outputs. This validation process will be based on a validation strategy taking into account the correlation between the validation stages and the ATM domains.The validation methodologies will be assessed with regards to the validation methodology. Guidelines, standards and validation techniques to be followed will be provided. An impact assessment on the system to be developed as well as on the existing validation tools of the validation process will be performed. Recommendation to other research tasks and the proposition of an organization of ATM validation will be other results of this project. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Combined fluorinated polymer and poly-L-lysine dendrimer as new potential contrast agents for magnetic resonance imaging 19F'.

assistant: **Objectives**

Early diagnosis of diseases, including tumors, is the ultimate goal of biomedical imaging. Magnetic resonance imaging (MRI) is a technique for non-destructive and non-invasive diagnosis of a number of diseases including cancer. Recently, contrast agents bearing 19F have been introduced as an attractive alternative to purely hydrogenated compounds, because of their high signal to noise ratio as result of their unique spectroscopic signature. This project aims to design, synthesize and characterize a series of novel fluorinated amphiphilic structures based on a fluoropolymer and a dendrimer (so called DendriGrafts, DGLs) based on poly-L-lysine. DGLs are a new type of arborescent biosynthetic polymer of regular and controlled structure. They have been shown to be biocompatible and non-immunogenic. It proposed that these DGLs to have potential as a powerful platform for the functionalization of hydrophobic polymers and to afford fluoropolymers for applications in 19F MRI. Combining DGLs and fluoropolymers in a good solvent for one of the blocks, is proposed to enable self-assembly of the amphiphiles into a variety of morphologies and molecular aggregates (including micelles, vesicles or cylinders). Increasing attention has been given to this type of supramolecular organization and to their potential use in applications such as coatings, drug delivery systems, nanoparticles or nanoreactors. Thus, this project will not only study the fundamental phenomena of self-organization of these novel copolymers but will also result in new materials suitable for application as novel agents in 19F MRI. Combining the complementary expertise from the Experienced Researcher in dendritic polymers, the host team in polymerization techniques and polymer self-assembly, a series of novel copolym
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Strengthening Ethics and Responsible conduct of Clinical Trials in East and Sub-Saharan Africa' to be submitted under Horizon Europe.

assistant: **Abstract**

The increased number of Clinical Trials taking place in Africa as well as the complexity of Clinical Trials designs require that the countries have the regulatory capacity to review, monitor and utilize data generated from the research. Research Ethics Committees/Institutional Review Boards, Institutional Animal Care and Use Committees and National Regulatory Agencies (NRAs) are required to be abreast with the evolving landscape thus require continuous capacity building as well as have platforms to share Clinical Trials information with both the public and private sector. The 11th Annual National Research Ethics Conference held in 2021 in Uganda highlighted challenges in the low and middle income countries for research ethics and open science specifically, the lack of infrastructure for open data sharing and fair data management. Specifically, i) lack of the national and regional guidelines and codes of conduct for scientific integrity ii) limited training and education in responsible conduct of research and pharmacovigilance. This proposal focuses on strengthening ethics and responsible conduct of Clinical Trials in East and Sub-Saharan Africa project through the establishment of a research ethics and integrity framework, open data access framework for Clinical Trials, E-learning platform for the Good Research Regulatory Research Practice Course and establishing Research Ethics Committees in National Regional Hospitals.  The consortium will leverage on the legal establishment of the institutions, collaborative efforts with the partner institutions, East African Health Research Commission (EAHRC), African Vaccine Regulatory Forum (AVAREF). Having a robust regulatory system, encompassing research integrity and open science will ensure that Clinical Trials is conducted to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The scattering of elastic waves by one-dimensional rough surfaces'.

assistant: **Concept**

Research objectives and content The scattering of elastic waves by effectively unbounded rough surfaces is to be studied. The object is to derive theoretical results as well as develop and analyse numerical methods to compute approximate solutions. The propagation of time-harmonic elastic waves in isotropic media is described by the Navier equation. In a first phase of the project, existence and uniqueness theorems for solutions to this equation in unbounded domains are to be derived employing boundary integral equation methods. Work is to be based on results for scattering of elastic waves by periodic surfaces currently underway and on results on scattering of acoustic waves by rough surfaces obtained at the host institution. In the second phase of the project, numerical methods for the computation of approximate solutions to the systems of boundary integral equations derived in phase one are to be developed and analysed. The procedure will involve truncation of the interval of integration, formulation as a linear system employing a Nystrvm method and solving this system utilising fast iterative schemes. It is hoped to limit the computational cost to O(N log N) operations. Training content (objective, benefit and expected impact) Training will mainly be provided in mathematical analysis of problems of scattering of waves by unbounded obstacles and development and analysis of fast iterative methods for the approximate solution of such problems, this second aspect being particularly attractive to me. The proposed project will complete my PhD studies and enable me to submit my thesis by September 2000. Links with industry / industrial relevance (22) Engineering literature displays great interest in reliable methods for the solution of scattering problems involving unbound
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Polar Regions and Quaternary Climate' under Fifth Framework.

assistant: **Concept**

The improvement of climate models and the ability to predict climatic changes caused by anthropogenic impacts needs a better understanding of the mechanisms of global climate changes. Paleoclimatology provides an excellent opportunity to investigate such mechanisms and polar ice cores are unique archives which allow a direct determination of the atmospheric concentration of greenhouse gases and climatic changes in the past.Europe has leading laboratories in the field of ice core recovery and analyses. Since about 12 years the efforts in polar regions are co-ordinated by European research projects. The Greenland Ice core Project (GRIP) successfully recovered an ice core at the Summit of the Greenland ice sheet and provided a wealth of information especially about fast climatic changes. North-South connections of the climate system remained very important open questions. Therefore, a new project with the goal to investigate past climatic changes by the analyses of two new ice cores to be drilled in Antarctica was implemented. The European Project for Ice Coring in Antarctica" (EPICA) is supported by the European Union. Ice core drilling has reached a depth of 1460 m at Dome Concordia (East Antarctica) and a second deep drilling will be started at Kohnen Station (Dronning Maud Land) in winter 2001/02.Ice core records are a cornucopia for climatologists, but the data will be of much higher value if they are used in state of the art climate models and if they are compared with ice core results from different regions as well as with other climate archives. Euroconferences are a very efficient and fast way to inform climatologists outside EPICA about the newest results and on the other hand inform EPICA members about the most urgent open questions. This will guarantee that the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modulating feeding behavior in obesity: from brain lesions to non-invasive brain stimulation targets' in the context of a Horizon Europe call.

assistant: **Objectives**

Altered feeding behaviors impair physical and psychosocial health and may lead to overweight or obesity. Obesity is a major global health challenge but current treatments are either ineffective in the long-term or carry important risks. Hence, novel therapeutic approaches are needed. The main ERC StG aims to explore the neural basis of eating patterns by exploring post-ingestive reinforcement of food-seeking behavior. In that context, we are studying the contribution of gut-brain communication towards activity in brain circuits controlling feeding behavior.Another strategy to clarify the neuroanatomy and neural correlates underlying dysfunctional human behaviors has been to study their occurrence when associated with a brain insult. We have used this approach for neuropsychiatric disorders, and believe it may also be used for feeding behavior. Indeed, changes in weight regulation concurrent with brain lesions have been described, raising the question of whether such lesions follow a particular distribution in the brain or impact specific functional networks. Several neuroimaging analysis methods can be used to explore if specific brain areas and/or connectivity networks are associated with specific lesional syndromes. In addition, these methods have also been proposed to offer the opportunity for development of novel strategies for therapeutic brain stimulation, such as transcranial magnetic stimulation (TMS).In this project, we aim to identify TMS targets that potentially modulate feeding behavior, supported by lesion topography and/or connectivity networks involving lesions associated with changes in feeding behavior and weight regulation. We will then conduct a TMS protocol targeting the identified regions to modulate feeding behavior in patients with obesity. We are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CROSSPATHS: Highway to Horizon Europe by pulling ERDF investments out of isolation through  a tailored sequence of synergies' in the context of a Horizon Europe call.

assistant: **Objectives**

CROSSPATHS is an initiative of recognised scientific entities from three Widening countries Estonia (EST), Poland (PL) and Portugal (PT). Each has benefited from investments into modern agri-food research infrastructures from ERDF funds to boost their innovation capacity and establish commercialisation pathways. Each, however, acts in isolation, suffering from low international recognition, weak links to excellent European networks, poor participation in competitive grant consortia, and lacking know-how and skills on how to best valorise investments in research infrastructures and other existing assets. An insightful mapping of our competences revealed unique expertise of each Partner such as food processing with valorisation of side streams (EST), green extraction techniques with identification of plant-based bioactive compounds (PT) and in vivo validation of their health-promoting effects (PL). We form a Group capable to deliver complex solutions in a food technology, health effects and bioeconomy. The overall objective of the project is to implement cross-border pathways to put in place sequential synergies between ERDF-funded investments and Horizon Europe opportunities. This will be achieved via strategies of internationalization and HR development that improve competitiveness, knowledge transfer and strengthened innovation capacity to jointly apply for international funding. To achieve this, we will be benefiting from Wageningen Research and Innotrope experience, networks and advice. Implementation of the CROSSPATHS will make of our consortium an attractive partner for Horizon Europe projects and beyond with well trained staff and established high reputation within ERA and internationally.


**Keywords:** plant food, food processing, side streams valorisation, gre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'GM and non-GM supply chains : their CO-EXistence and TRAceability'.

assistant: **Concept**

The objective of Co-Extra is to provide all the stakeholders of the food and feed chains with a central decision-support system integrating the tools, methods, models and guidelines needed to deal with the imminent arrival of large quantities of GMOs, further to the lift of the current de facto ban on GMOs in the EU. Co-Extra will study and validate biological containment methods and model supply chain organisations and provide practical tools and methods for implementing co-existence. In parallel, Co-Extra will design and integrate GMO detection tools, develop sampling plans, and elaborate new techniques to meet the challenges raised by stacked genes and as yet unapproved or unexamined GMOs. Co-Extra will also study and propose the most appropriate information structure, content and flow management for ensuring reliable and cost-effective documentary traceability. All of the methods and tools that will be studied and developed will be assessed not only from the technical point of view but also with regard to economic and legal aspects. In parallel, to promote harmonisation of co-existence and traceability practices around the world, Co-Extra will survey the GMO-related legal regimes and practices that exist in and beyond the EU. Stakeholders will be involved in the project from the start through the dialogue platform, editorial offices, focus groups, national relays, etc. Co-Extra outcomes will contribute to reinforcing consumers confidence in labelling claims and therefore EU products at large. By helping economic stakeholders to meet consumers requirements for reliable choices, Co-Extra will improve European competitiveness. Co-Extra outcomes will be proposed to standardisation after validation. Dissemination activities will largely benefit from the strong commitment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'From Anderson localization to Bose, Fermi and spin glasses in disordered ultracold gases' (ALOGLADIS) targeting Seventh Framework.

assistant: **Abstract**

The field of disordered quantum gases is developing rapidly. Dramatic progress has been achieved recently and first experimental observation of one-dimensional Anderson localization (AL) of matterwaves has been reported using Bose-Einstein condensates in controlled disorder (in our group at Institut d'Optique and at LENS; Nature, 2008). This dramatic success results from joint theoretical and experimental efforts, we have contributed to. Most importantly, it opens unprecedented routes to pursue several outstanding challenges in the multidisciplinary field of disordered systems, which, after fifty years of Anderson localization, is more active than ever.This theoretical project aims at further developing the emerging field of disordered quantum gases towards novel challenges. Our aim is twofold. First, we will propose and analyze schemes where experiments on ultracold atoms can address unsolved issues: AL in dimensions higher than one, effects of inter-atomic interactions on AL, strongly-correlated disordered gases and quantum simulators for spin systems (spin glasses). Second, by taking into account specific features of ultracold atoms, beyond standard toy-models, we will raise and study new questions which have not been addressed before (eg long-range correlations of speckle potentials, finite-size effects, controlled interactions). Both aspects would open new frontiers to disordered quantum gases and offer new possibilities to shed new light on highly debated issues.Our main concerns are thus to (i) study situations relevant to experiments, (ii) develop new approaches, applicable to ultracold atoms, (iii) identify key observables, and (iv) propose new challenging experiments. In this project, we will benefit from the original situation of our theory team: It is indepe