RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Agile Co-Creation of Robots for Ageing'.

assistant: **Concept**

The mission of ACCRA is to enable the development of advanced ICT Robotics based solutions for extending active and healthy ageing in daily life by defining, developing and demonstrating an agile co-creation development process. To this end, a four-step methodology (need study, co-creation, experimentation, sustainability analysis) will be defined and applied in three applications (support for walking, housework, conversation rehabilitation) and assessed in France, Italy, Netherlands and Japan. The three applications will be based on a FIWARE platform integrating a number of enablers including features of universAAL and supporting two robotics solutions, Astro (Robot) and Buddy (Robot companion). The MAST impact assessment framework will be used integrating the following dimensions: user perceptions, user outcomes, ELSI, economic aspects, technical aspects, organisational aspects.ACCRA is a joint European-Japanese initiative including a multidisciplinary team of 6 European partners and 3 Japanese partners. The project has a three-year duration. It is structured to allow for balanced contribution and efficient synergistic collaboration between Europe and Japan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SMART-ACTION' (SMART-ACTION) under Seventh Framework.

assistant: **Objectives**

With the increasing miniaturization of communication devices and the proliferation of technologies such as smart phones or sensor networks, the concept of an Internet of Things (IoT) is becoming a reality, especially with their integration into Smart Cities.<br/>The interdisciplinary nature of IoT work requires understanding, coordinating, supporting and engaging not only ICT, but also other areas such as biotechnology or nanotechnologies, that provide the right context in which IoT concepts can be embedded to provide solutions that can benefit society at large.<br/>SMART-ACTION will support the development of strategic research agendas and serve as an enabler for the dissemination and further integration of results into future research and industrial developments, while coordinating international efforts.<br/>The main objective of SMART-ACTION is to provide support for International Road Mapping of the Research Agenda and Policies of IoT as part of the Future Internet Technological Development and to increase the uptake of European industry and businesses related to IoT, serving the Lisbon Agenda.<br/>SMART-ACTION has several strategic goals:(i) To consolidate the current research and technology transfer activities in Europe and to make sure the efforts performed by individual research groups generate an optimal effect on others research areas.<br/>(ii) To extend the reach of IoT technologies beyond Europe and to make sure that Asia, the US, Australia and Africa are all involved in the process of defining an overall strategy for the Internet of Things by providing input to workshops organised as part of SMART-ACTION.<br/>(iii) To make sure that companies are also involved in the process to make sure that roadblocks and potential problems are identified and solved as ea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Imaging the proteome at the nanoscale'.

assistant: **Concept**

The key principle of biological imaging is specific labeling. The protein of interest is revealed by tagging with fluorophores, either by genetic encoding, using green-fluorescent-protein (GFP) variants, or by affinity labeling, using antibodies. This procedure has been successful for several decades, but has the great disadvantage that each protein needs to be tagged individually: specific antibodies are needed for each and every protein. This limitation stops imaging from becoming a high-throughput “omics” approach. We propose to change this here, through an imageomics approach based on a combination of probe development and nanoscale imaging. We will develop affinity probes that bind with high specificity not to specific proteins, but to amino acid sequences (peptides) that are present in more than one protein. We will choose 20-40 such peptides, in a fashion that ensures that virtually every protein in the human proteome contains a specific subset of the peptides. We will then develop nanobodies that bind to each of these peptides. We prefer nanobodies to antibodies, based on their small size and optimal penetration into biological samples. We will then use the nanobodies to label biological samples, and we will image them at the nanoscale, with a resolution that is sufficient to reveal single proteins. By applying the nanobodies in a combinatorial fashion, we will “read” the sequence of each protein in the preparation, which will result in an image of its whole proteome. We will start by applying this approach to 2-dimensional samples, such as fluids adsorbed to coverslips. This will lay the foundation for future diagnostic studies for a variety of human diseases, based on human fluids such as plasma or cerebrospinal fluid. In a later stage, we will proceed to anal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AI supported picture analysis in large bowel camera capsule endoscopy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Millions of Europeans undergo optical colonoscopy (OC) every year as a part of diagnostic procedures for bowel issues such as possible bowel cancer. For citizens and patients OC is associated with discomfort, possible complications and sick-days from work, which affects the acceptability to undergo the procedure. OC also constitutes a heavy burden on European hospital capacities. Colon capsule endoscopy (CCE) is a technology that has the potential to replace a substantial proportion of OCs. Studies have shown that CCE is preferred by patients over OC, has a lower complication rate and can be performed out of hospital, in the home of the patient. Thus, CCE holds great potential for both patients and hospitals. However, the current diagnostic process of CCE includes a time-consuming manual reading of the images captured by the capsule (the so-called ""camera pill"") done by trained medical staff, which is both expensive and prone to human error. For CCE to be a viable alternative to OC in clinical practice, these challenges need to be addressed. Therefore, the goal of the AICE project is to develop and validate a set of artificial intelligence algorithms that can assist in the reading of the CCE images to ensure both high quality diagnostics and save crucial clinical resources. The AICE project aims to create a complete and validated AI-assisted pathway that improves CCE diagnostics making the technology clinically viable for the good of patients, health care systems and society. A number of the partners in AICE have been collaborating for a number of years and have completed development of several AI algorithms (AIA) for CCE diagnostics that are now in need of external clinical validation. More algorithms will be completed and prepared for validation within the first 2 y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on '3D Engineered Environments for Regenerative Medicine'.

assistant: **Innovation**

This proposal develops a unified, underpinning technology to create novel, complex and biomimetic 3D environments for the control of tissue growth.  As director of Cambridge Centre for Medical Materials, I have recently been approached by medical colleagues to help to solve important problems in the separate therapeutic areas of breast cancer, cardiac disease and blood disorders.  In each case, the solution lies in complex 3D engineered environments for cell culture.  These colleagues make it clear that existing 3D scaffolds fail to provide the required complex orientational and spatial anisotropy, and are limited in their ability to impart appropriate biochemical and mechanical cues.I have a strong track record in this area.  A particular success has been the use of a freeze drying technology to make collagen based porous implants for the cartilage-bone interface in the knee, which has now been commercialised.  The novelty of this proposal lies in the broadening of the established scientific base of this technology to enable biomacromolecular structures with:(A) controlled and complex pore orientation to mimic many normal multi-oriented tissue structures(B) compositional and positional control to match varying local biochemical environments,(C) the attachment of novel peptides designed to control cell behaviour, and(D) mechanical control at both a local and macroscopic level to provide mechanical cues for cells.These will be complemented by the development of(E) robust characterisation methodologies for the structures created.These advances will then be employed in each of the medical areas above.This approach is highly interdisciplinary.  Existing working relationships with experts in each medical field will guarantee expertise and licensed facilities in the required
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of symbiont diversity in resilience to temperature fluctuations.' (SymFlux), addressing dissemination and exploitation.

assistant: **Impact**

Beneficial microbes are essential for many animals and mutualistic interactions must be able to withstand environmental changes such as temperature fluctuations. However, with changing ocean temperatures induced by climate change, it is unclear whether symbioses will be able to adapt, leaving marine organisms at risk. Therefore, this proposal will characterize how bacterial symbionts respond to changing temperatures and identify whether microbes can increase symbiotic resiliency to temperature stress. To pursue this topic, the symbiosis between the squid Sepiola affinis and its symbionts (V. fischeri and V. logei) will be used. The project uses a unique squid husbandry facility to pursue three main objectives. The first objective will characterize initial and persistent colonization in the S. affinis light organ. Using confocal microscopy and genetic labelling, strain behaviors during colonization will be described. The second objective will examine how temperature affects colonization. The third objective will screen Vibrio spp. for growth under temperature fluctuations. RNA sequencing and metabolomics will be used to identify molecular mechanisms underlying resilience to temperature fluctuations. Finally, genetic modification and both in-vitro and in-vivo growth assays will test whether molecular candidates promote temperature resilience. The project will have a two-way transfer of knowledge, with the researcher providing knowledge of Vibrio spp. and bacterial genetics with the host institution providing bioinformatics and small molecule analysis. The SymFlux project will position S. affinis as a model for symbiosis research in Europe as well as contribute knowledge of how symbioses can adapt to climate change.


**Keywords:** Symbiosis, Host-microbe interaction, Vibr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'InSwitch – Ultra-Compact Electronic Solid-State Device for  Induction Motor Starting and Performance Improvement' (INSWITCH) under Horizon 2020.

assistant: **Objectives**

The proposed feasibility study respects to a project to develop, manufacture and commercialize worldwide of an ultra-compact, self-powered, electronic solid-state device for optimized soft-starting and steady-state performance improvement of fixed-speed three-phase squirrel-cage induction motors, by means of a novel automatic load-based stator winding connection-mode management technique. It also performs advanced motor protection and fault diagnosis. One of the most disruptive features of the proposed device is that it can be installed inside the motor terminal box. In can potentially be installed in more than 100 million of induction motors worldwide, replacing the obsolete electromechanical star-delta starters and compete with electronic soft-starters. From a conservative perspective, it is estimated that the World market for this device can reach 7500 M€/year in revenues, being an excellent business opportunity. Furthermore, the proposed technology is in line with the general trend toward solid-state solutions due to the inherent higher reliability. The device manufacturing will be outsourced, but the design and commercial exploitation will be fully managed by OptiSigma. “SME Instrument - Phase 1” funding will be used to produce a complete feasibility study in which the technical, economic, financial and commercial aspects are analyzed in detail, offering key information regarding the design, construction, certification, IP management, manufacturing and commercialization of the proposed product, as well as a market assessment in terms of dimension and risks. A detailed well-grounded business plan, SWOT analysis and a business model will be also included in the final feasibility report. The results will be used to prepare a proposal for “SME Instrument - Phase 2”, as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A cross-species neurogenomics approach to anxiety' (GENANX) targeting Seventh Framework.

assistant: **Abstract**

My goal is to identify novel genetic factors that regulate normal and pathological anxiety. Anxiety disorders are complex diseases with genetic and environmental susceptibility factors. Stressful life events, especially in childhood are well-known risk factors for anxiety disorders. We have previously used inbred mouse strains to identify genes underlying innate anxiety. Here I propose a new approach using a mouse model of anxiety induced by social stress to identify gene regulatory networks, to show the causality of the selected networks in vivo, and to investigate involvement of these networks in the genetic predisposition to human anxiety disorders. Gene regulatory networks will be identified by using massively parallel sequencing methods (i.e. miRNA-seq and mRNA-seq). We will generate from four brain regions known to regulate anxiety a complete gene and miRNA expression atlas, which is used to identify genes, transcripts, miRNAs and isomiRs differentially expressed between anxious and control animals. Pathway and network analysis tools are employed to identify molecular pathways affected by induced anxiety. Datasets consisting of different levels of data from individual brain regions will then be integrated in light of existing molecular and anatomical information to construct draft network models that will be curated, filtered and enhanced. On the basis of these models, we will generate specific hypotheses that are tested in vivo in mice to show the causality of the most interesting networks. To identify the networks important for human anxiety disorders, we have access to a unique population-based cohort from Finland characterized for anxiety disorders. Candidate genes and miRNAs from selected networks are tested in a genetic association analysis. This multidiscip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Revolutionary new quantum chemical software for molecular simulations' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the 2000s, the application of quantum chemistry became available to various industries due to the successful findings resulting from years of research. Nowadays several pharmaceuticals are using quantum chemical methods to develop medicine molecules by replacing difficult and expensive tests with simulation techniques, therefore making the development process more efficient, faster and more cost-effective.Quantum chemical methods require a huge computational demand, which is the biggest difficulty of its spread. According to the latest trend of computer studies the solution for the quantum chemistry calculations is the multi processor Graphic Processing Unit - GPU, which requires special programming models’ adaptation.The aim of the project is the establishment of a GPU-optimized Gauss based, efficient, parallel quantum chemical integrator module, which could solve one of the speed limitation of quantum chemistry calculations, the calculation of integrals.With our revolutionary product new R&D fields can be available, moreover pharmaceutical and manufacturing companies could significantly reduce the required time of the market launch, saving hundreds of millions of Euros, helping chemists find the perfect candidate with the perfect features and reducing the chance of molecules’ failing during further phases of thedevelopment. Currently, there is no computer software which has the required capacity.The complete software will be available as a licensed module for companies, which are seeking general quantum chemical software. With this module they are going to be able to execute specific calculations (e.g.: SCF, DFT, (RI)-MP2, CC, etc.) more efficiently than their competitors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ultrafast two-photon imaging of immature GABAergic networks in the hippocampus' (2002-2006) under Sixth Framework.

assistant: **Objectives**

GABAergic interneurons play a crucial role in the generation of network activities. In the hippocampus, several types of synchronous network activities controlled by GAB Aergic interneurons have been described as the GiantDepolarizing Potentials (GDP) in immature animals or the slow, gamma and theta oscillations observed in the adult ones. These activities are associated with numerous physiological functions such as slow-wave sleep, memory and exploration processes. Network activity is determined by its structure and by the properties of synaptic transmission between the neurons that compose it. Our aim is to study the morpho-functional structure of the early GABAergic network, since, in the hippocampus; it is the first circuit to be functional. GABAergicsynapses are formed prior to glutamatergic ones. Dendritic projecting interneurons develop prior to peri-somatic projecting ones.These data indicate that the early purely GABAergic network is strongly modified along astereotyped sequence, during the first post-natal week to be progressively interconnected with the excitatory network and to finally play a key role in the control of excitatory influx We will study slices from the immature hippocampus, using a double experimental strategy: an integrated approach using ultra-fast two-photon microscopy to image calcium transients with millisecond resolution to reconstruct the dynamics of the entire network activity with single-cell resolution, combined with a unitary approach using whole-cell multiple patch clamp recordings to characterize the physiological properties of the individual elements implicated in the network activity. This project will provide essential information to better understand the maturation of the GABAergic circuit that generate the main excitatory syna
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovation Support Network East Mediterranean' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Aim of the project is to become a true one-stop-shop for business and innovation support along the entire value chain, providing its services in the proposed region the context of HORIZON 2020 Programme and in line with the Europe 2020 strategy. innovation support services will helpstrengthen the competitiveness and sustainability of regional enterprises.Proposed project will  include two acitivity type which are “Key account management under the SME Instrument of Horizon 2020” and “Services to enhance the innovation management capacities of SMEs”


**Keywords:** Innovation support, Key Account Management, SME Instrument