RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Feasibility study of a microturbine for delocalized electrical energy, off-grid generation'.

assistant: **Innovation**

Advanced Microturbines S.r.l. developed a microturbine for local generation of electricity from pressurized gases, in the range of 20-50W. The present study will evaluate the feasibility of energy storage and supply system for off-grid applications, based on the microturbine technology, characterized by being low costs, low carbon, flexible, robust and easy to maintain. From a business standpoint, the market need for a similar device was realized by the experience of the proposer in the oil&gas industry. In this context, having a local and distributed energy generation in smart distribution grids represents a potential for cost saving and performance improvements:  for example, leakages can be detected by distributed sensors and information sent via wireless transmitters, powered by the microturbine. The microturbine can be used in two operating modes:• As micro-turbo expander exploiting available pressure drops for generating electricity to power up delocalized sensors and transmitters.• As air-powered generator, supplying critical loads for short periods, taking energy from a pressurized tank.Three main objectives shall be reached during the feasibility: a first validation of the technical concepts, a detailed picture of the markets (smart distribution grids, remote off-grid repeaters and possible niches) and a refined business model and plan. On these results, Advanced Microturbines S.r.l. is willing to base the application for phase2. In line with its objectives, the study will include the following activities:Analysis of the technical scenario and concept design: trends and current IPR scenarios, preliminary list of technology suppliers and potential future partners. Study of the markets: trends, Porter’s 5 Force analysis, strategy for market entering. Business mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'WHY DO THEY DIE? DECIPHERING AND QUELLING THE LETHAL CUES OF IMMUNO-INFLAMMATORY RESPONSE IN SEPSIS' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Sepsis is a multifaceted disease that remains a serious clinical problem and causes frequent mortality in human patients worldwide. The proposed project addresses the mechanisms and prevention of early mortality in experimental sepsis. To replicate human sepsis, murine models of live Escherichia coli and Streptococcus pyogenes systemic infusion and cecal ligation and puncture (CLP) peritonitis will be used. The project consists of three aims investigating acute immuno-inflammatory signaling triggered by a septic event: Aim I will study the role and modulation of differential genomic expression upon survival/mortality in gram-negative vs. gram-positive systemic sepsis. Based on the retrospective comparison of outcome in CLP sepsis, Aim II will differentiate between the non-lethal and lethal: (1)-gene/protein expression of inflammatory cytokines and (2)-changes in neurotransmitter fluctuations in different brain regions. Aim III will employ the novel strategy of prospective outcome-based stratification and investigate the effectiveness/mechanism of immuno-modulative anti-inflammatory therapy upon survival in mice predicted to die of acute CLP-induced polymicrobial peritonitis. There is an urgent need for treatments improving outcomes in sepsis and a rise of a new effective, individual patient-based therapy against sepsis is contingent upon exhaustive understanding of its immuno-inflammatory fingerprints. Successful accomplishment of the projected study will contribute to this effort.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Artificial Life Today Anthropological and Sociological Analysis of Life Engineering' to be submitted under Horizon 2020.

assistant: **Abstract**

We are witnessing profound changes in our societies via biosciences and bio-technologization. Biotechnologies, synthetic biology, and new genetics in general represent key areas of life sciences, characterised by rapid technological and scientific development. The biotechnologies as key areas of contemporary cultural and social transformations are influenced by specific technological rationality and power that is inscribed in the very foundations of modern society. The power is biopower/biopolitics, which names, creates, and controls life. The project addresses contemporary challenges in the field of biopolitical life engineering, specifically in case of PGD (preimplantantion genetic diagnosis) technology. There is a lack of reflection on the broader social and cultural context and on the ramifications of synthetic life engineering, PGD in the Czech Republic from the anthropological and sociological points of view. These issues remain unanalysed, contributing to a lack of understanding of the specific concerns of synthetic life and life sciences in the Eastern European and post-socialist context. This proposed project will analyse social context of technology PGD in the Czech Republic in comparison with Germany. This project is guided by the main questions: How is the field of life engineering, particularly PGD technology, culturally and socially structured in the Czech Republic in comparison with Germany? What kinds and forms of agency are involved there? Are there any specific concerns in public debates relating to life engineering in comparisons of Eastern and Western Europe? The main aim of this research, which will be conducted on case studies of two European countries, is to analyse and interpret through sociological and anthropological perspective the ways in whi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Initiation Mechanisms of Lipid-driven Diseases'.

assistant: **Innovation**

The metabolic syndrome and its several manifestations have currently taken a tremendous toll on many aspects of society.  Nonalcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome while atherogenic dyslipidaemia, and especially apolipoprotein B (ApoB)-containing lipoproteins, is considered the major causal mechanism in atherosclerosis initiation and progression. By employing novel humanized mouse models that can be rendered acutely dyslipidemic, we have already demonstrated that, at the very onset of dyslipidemia, ApoB-containing lipoproteins interact with immune cells in the liver causing immune and metabolic changes, including ectopic lipid deposition. This opened to the idea that the inflammatory response evoked by acute dyslipidemia plays a pivotal role in the initiation of other important lipid-driven diseases such as NAFLD.  Hereafter, we present experiments to elucidate novel mechanisms central to the pathogenesis of NAFLD. We will better define the nature of the innate immune cells that firstly react to a dyslipidemic insult. This will be accomplished by imaging  the different hepatic macrophage subsets after transition to dyslipidemia and by examining the physiological changes caused by liver Kupffer cells depletion. Secondly, we will investigate how this initial hepatic response will in turn affect atherosclerosis initiation and progression. We will target atherogenic factors secreted by liver immune cells upon ApoB uptake and inhibit several of them in vivo using neutralizing antibodies. Finally, by employing 2H2O to trace lipids' synthetic rates, we will clarify whether the hepatic lipid accumulation observed in our mice is of endogenous or exogenous sources. This project will yield powerful insights on targetable m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Predicting the impacts of river reconnection, biological invasions and climate change for the conservation of endangered cold-water fishes in Europe' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

River fragmentation and biological invasions are driving extirpations of cold-water fishes in Europe, with extirpations exacerbated by climate change. River barriers that cause fragmentation can prevent invasive species from dispersing further upstream (by forming an impermeable invasion front), but also impede the upstream movements of cold-water fishes (such as salmonid fishes), preventing their access to cooler waters towards the headwaters. The facilitation of movements of salmonids above barriers can be achieved through building fish passes on the structure, providing an easier route upstream, but this also opens up the invasion front for the invasive species. This Action explores this conservation disjuncture between alleviating river fragmentation through fish pass construction that aims to conserve threatened populations of cold-water fishes through reconnection and access to cool waters versus the fish passes opening up the extant invasion front to a highly invasive and impacting fish. Using the River Teme, Western England, as our study system, European barbel Barbus barbus as the model invader, and brown trout Salmo trutta and endangered Atlantic salmon Salmo salar as the model cold-water salmonid fishes, our objectives are to (i) compare and contrast the spatial and thermal ecology of barbel at the invasion front versus their core range, and identify the risk of their upstream dispersal over barriers via fish passes according to phenotypic variability; (ii) quantify the ecological interactions of salmonids and barbel throughout the study river and across different population abundances; and (ii) develop novel predictive models that predict conservation outcomes by simulating how river management schemes to promote salmonid conservation might instead drive the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Using genetics to improve the quality and safety of sheep products' under Fifth Framework.

assistant: **Concept**

The project addresses the safety and quality of food in the sheep production chain, using genetics. Partners from France, UK, Italy and Spain with expertise in(I) milk and meat sheep,(ii) traits related to animal health and product quality, and(iii) genetics are brought together to share resource and results in the aim to create a critical mass of researchers. The project will:(I) share genetic resource populations(ii) share the genotyping of the animals(iii) measure traits related to food quality and safety including CLA of the milk, mastitis resistance, nematode parasite resistance and nasal botfly resistance(iv) study candidate genes and functional genomic for theses traits(v) perform biological and QTLanalysis of the data. Outputs include knowledge on food safety and quality traits. QTL and candidate genes, and implementation strategies. Participation of breeding organisations means that the results will be applied immediately to the sheep sector
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Type and Proof Structures for Concurrent Software Verification' to be submitted under Horizon 2020.

assistant: **Abstract**

Verification of concurrent software is a notoriously difficult subject, whose complexities stem from the inability of the existing verification methods to modularize, and thus divide-and-conquer, the verification problem.Dependent types are a formal method well-known for its ability to modularize and scale complex mathematical proofs. But, when it comes to programming, dependent types are considered limited to the purely functional and terminating programming model.The grand challenge of this project is to remove the limitation and scale dependent types to support implementation of stateful concurrent programs, and their correctness proofs, simultaneously. By applying the modularizing power of dependent types to both programs and proofs, the project will obtain novel and scalable foundations for the field of concurrent software verification.Writing mechanized proofs of software, concurrent or otherwise, is generally considered infeasible. But if one chooses the right linguistic abstractions to express the proofs, we argue that it does not have to be so. This observation is supported by our encouraging preliminary results. The project will discover further novel linguistic abstraction that facilitate engineering of practically feasible formal proofs, and experimentally evaluate them by mechanically verifying extensive concurrent programs drawn from realistic applications, such as concurrent garbage collectors, OS kernels, and popular open-source concurrent libraries.The project is high risk because it proposes novel foundations for concurrent software verification, whose development requires deep intertwining of logic and program semantics theory, with significant hands-on implementation and experimentation with formal proofs. But it is also high gain, as scaling concurr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Remote Assessment of Disease and Relapse – Alzheimer’s Disease' (RADAR-AD), addressing dissemination and exploitation.

assistant: **Impact**

There is an urgent need for novel approaches assessing functional decline in early AD. The main goal of the RADAR-AD project is to develop a digital platform to detect subtle functional deficits in early Alzheimer’s disease (AD) individuals by integrating a meaningful combination of smartphone, wearable and/or home sensor based parameters. The system developed will be suitable for future longitudinal studies, including trials. The objectives are to 1) Identify the most relevant functional domains and the most promising remote measurement tools (RMTs) for these domains based on reviewing the literature and piloting of RMTs in small studies; 2) Optimise the RADAR-CNS platform for use in AD studies; 3) Test the platform and selected RMTs in a real world environment clinical study with 240 participants across the AD spectrum ranging from the preclinical AD to the dementia stage; 4) Perform statistical modelling to estimate longitudinal predictions; 5) Discuss results with regulatory agencies in order to obtain guidance about how to develop a path for formal qualification as outcome measurements in future therapeutic interventions. Considering the limited budget and project duration, we will rely upon already available technology platforms and on available longitudinal datasets where possible. The consortium includes experts in clinical dementia studies, computer science, bioinformatics, regulatory policies, ethics, and patient and public involvement (PPI). Additional strengths of the consortium are the deep and broad interface with RADAR-CNS and related IMI projects, and the access to large amount of patient-level data from key European cohort studies for modelling purposes.


**Keywords:** functional impairment,  patient and public involvement (PPI),  digital platform
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Phase-sensitive Alteration of Light colorAtioN in quadri-parTIte gaRnet cavIty', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The elder wand of telecom wizards would coherently change the color of light. But while the laws of physics do allow mutating the photon chroma, all attempts to date have been very inefficient for large frequency mismatches. PALANTIRI will initiate a technological breakthrough by providing a viable development path for integrating the coherent and efficient interconversion of information between microwaves and light on a chip. We propose a radically new approach building on quadripartite (microwave photon-magnon-phonon-optical photon) hybridization process. The idea is to exploit opto-mechanical effects while inserting a magnetic element that maintains high cooperativity both with a mechanical mode through magneto-acoustic coupling and with the microwave antenna through inductive coupling, while exploiting magnetic texture to achieve perfect matching of the microwave precession profile with the optical mode. This opportunity has recently emerged from progress in material science, which allows the fabrication of freestanding micron-size slabs of ultra-high quality magnetic insulator yttrium iron garnet. The suspension greatly suppresses any leakage of phononic or photonic oscillating energy through the substrate. PALANTIRI’s scientific objectives are to deliver within 42 months a proof of principle on-chip analog coherent frequency converter with efficiency of the order of unity (TRL2). The delivered phase-sensitive device will provide the breakthroughs needed to achieve a radical expansion of the connectivity capacity of a backhaul network for enabling high-speed internet access for everyone from any location. It will also provide the elementary brick to build the quantum-ready internet infrastructure of the future. To achieve these goals, our consortium consists of six
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Quantitative Graph Games: Theory and Applications'.

assistant: **Innovation**

The theory of games played on graphs provides the mathematical foundations to study numerous important problems in branches of mathematics, economics, computer science, biology, and other fields. One key application area in computer science is the formal verification of reactive systems. The system is modeled as a graph, in which vertices of the graph represent states of the system, edges represent transitions, and paths represent behavior of the system. The verification of the system in an arbitrary environment is then studied as a problem of game played on the graph, where the players represent the different interacting agents. Traditionally, these games have been studied either with Boolean objectives, or single quantitative objectives. However, for the problem of verification of systems that must behave correctly in resource-constrained environments (such as an embedded system) both Boolean and quantitative objectives are necessary: the Boolean objective for correctness specification and quantitative objective for resource-constraints. Thus we need to generalize the theory of graph games such that the objectives can express combinations of quantitative and Boolean objectives. In this project, we will focus on the following research objectives for the study of graph games with quantitative objectives:(1) develop the mathematical theory and algorithms for the new class of games on graphs obtained by combining quantitative and Boolean objectives;(2) develop practical techniques (such as compositional and abstraction techniques) that allow our algorithmic solutions be implemented efficiently to handle large game graphs;(3) explore new application areas to demonstrate the application of quantitative graph games in diverse disciplines; and(4) develop the theory of games o