RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The molecular basis of ineffective erythropoiesis in Sickle Cell Disease' (InEr-SICKLE).

assistant: **Innovation**

In this project, I will investigate ineffective erythropoiesis as a contributing factor and potential therapeutic target in the pathogenesis of sickle cell disease (SCD), one of the most prevalent genetic disorders in man and a global health problem. I will employ cutting-edge proteomic and genomic approaches to investigate in detail deregulation of the master erythroid transcription factor GATA1 as a result of oxidative stress in sickle red blood cells, as the basis for ineffective erythropoiesis in SCD. I will also investigate whether restoring GATA1 functions can alleviate ineffective erythropoiesis, thus providing alternative therapeutic opportunities in treating SCD. Lastly, I will generate novel cellular models for SCD from patients that can be used in dissecting the pathophysiology of SCD and in screening for agents that can alleviate IE and sickling. My project will generate novel insight into SCD pathogenesis and tools that can lead to the development of novel therapeutic approaches. My background in SCD cellular pathophysiology is highly complementary to those of my supervisors, Prof. John Strouboulis who is an expert in GATA1 functions in molecular erythropoiesis and Prof. David Rees, who is a world leading clinician in pediatric sickle cell disease. I stand to benefit greatly by receiving excellent training in -omics, functional assays in molecular erythropoiesis and in clinical aspects of SCD, that will enable me to progress into a career as an independent investigator.


**Keywords:** Sickle Cell Disease, hematology, erythropoiesis, transcription factors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Man machine interface for remote operation of civil works equipment' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The project aims to design, integrate and validate in demonstration, a full scale, motorised, 5-DOF simulator - module for civil works machines. The simulator should re-construct the visual, auditive and dynamic conditions as they would be perceived by the driver in the machine. An important issue of the development being the final system cost, the simulator will be designed avoiding highly expensive component options, regarding visual displays, image and audio treatment etc. On the other hand, in order to enhance the agility and precision of the tele-operated system, an important objective of the development consists of implementing a dual force-reflecting kinaesthetic link between the machine and the operator as follows: -1. A force-feedback loop will connect the overall dynamics of the machine with the driving seat, in a way that the operator may sense" the motion of the machine at work, such as vibrations, impacts during work, or displacement, inclination, lifting etc. -2. A second force-reflecting loop will permit to the driver to "sense" the efforts produced by the working parts of the machine (such as the arm and bucket, in the case of an excavator), through force-feedback on the driving instrumentation, joy-sticks, pedals) of the simulator. Another important objective of the development is to produce a comprehensive know-how basis for generic tele-operation equipment. The purpose is to permit the mounting of the tele-operation module on existing machines (such as standard excavators) and avoid the need for investment by the users on the complete new equipment. For this reason, a generic electro-hydraulic interface will be designed, which will permit to connect the tele-operation module on an important range of civil works machines. The final important issue of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Process diagnosis for plant performance enhancement' (PROGNOSIS).

assistant: **Concept**

A major technological challenge facing the processing industries is the need to increase plant flexibility and provide wider operating windows. This is particularly important in highly demanding situations where processes are subject to varying raw material properties, changing market needs and specifications and fluctuating operating conditions due to equipment or process degradation. The industrial necessity for techniques which enhance process performance will require new methodologies to be adopted which can be used across a spectrum of industrial processing unit operations and on a wide range of products. Particularly exciting are the multivariate data analysis methodologies which are appropriate for a diverse range of industrial problems, including plant-wide performance monitoring. Radical improvements can be made to the quality and consistency of existing production. However, it is not simply a case of more automation, but of implementing these new techniques for data handling and interpretation at all levels, from process operator, production engineer through to plant manager and senior management.The objective of PROGNOSIS (Process Diagnostics for Plant Performance Enhancement), is to demonstrate, the improvements that can be achieved in plant performance monitoring, through the application of Multivariate Statistical Process Control (MSPC) to a number of production processes, and products. The basis of MSPC are the statistical projection techniques of principal components analysis (PCA) and Projection to Latent Structures (PLS). Through the extension of these techniques, batch and plant-wide MSPC applications can be achieved through multi-way PCA and PLS and multi-block PCA and PLS respectively.The major benefits expected to accrue will be an increase in asse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Building Energy decision Support systems fOr Smart cities' (BESOS).

assistant: **Innovation**

The strategic goal of BESOS is to enhance existing neighborhoods with decision support system to provide coordinated management of public infrastructures in Smart Cities, and at the same time provide citizens with information to promote sustainability and energy efficiency.The project will target two main stakeholders: the owners of the infrastructure –municipalities – and its operators – ESCOs. The former will be provided with a Business Balance Score Card to audit the SLAs established with the ESCOs against a number of KPIs. The latter will make use of the same tool to analyze new business models, and will be also provided with a DSS Cockpit to Monitor and Control information from the infrastructure and establish coordinated energy efficiency strategies.Different Energy Management Systems within a smart city will be able to share data and services through a new Open Trustworthy Energy Service Platform. Stakeholders as ESCOS, public authorities, Distribution and Transmission System Operators, and domestic users, will be able to access and interface the existing infrastructure in smart cities.As an additional benefit, the deployment of such platform will open new opportunities to mobile application developers willing to increase energy efficiency awareness among citizens.BESOS will be tested in two leading cities: Lisbon and Barcelona. The assets that are available for the trials include: public lighting (>150000 luminaries), public buildings (>150), residential buildings (250), PV micro-generation (55 installations), wind turbines, smart heating, cogeneration, electrical vehicle charging points (> 250), and mobility systems (> 40000 traffic lights). In total >250GWh/year of consumed electricity and 168 MWh/year of produced electircity.The transferability of results is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Productivity and carbon transformations on the Greenland Ice Sheet', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Glaciers cover 10% of the Earth’s land surface and represent an important, yet very little studied, ecosystem. The biogeochemical cycling of carbon in the glacial ecosystem is largely influenced by microbial communities on glacier surfaces that mainly consist of heterotrophic and photoautotrophic bacteria. They have the potential to play a significant role in regional carbon budgets by means of primary and secondary production and respiration, and it is very important to evaluate their contribution on a large scale. However, to provide a credible supraglacial carbon budget, a study is needed in which C concentration and transformation rates in the supraglacial environment are related to the limiting factors, including the source of microbes and nutrients. Quantification of such a relationship will provide a powerful tool for global carbon budget models. The underlying hypothesis of the proposed research is that the productivity of the supraglacial ecosystem is constrained primarily by the source of microbial cells, and secondarily by rock-derived nutrients. The principal source of microbes and rock-derived nutrients is wind-borne debris originating in deglaciated areas close to the glacier margin. Thus, the main hypothesis to be tested in this study is that there is a relationship between the distance of a site on the glacier surface from the glacier margin and the abundance and activity of the local microbial community. The objectives of this study are to quantify the spatial distribution of surface debris on the Greenland Ice Sheet along a gradient from the glacier edge to the equilibrium line, to determine the quantity and quality of C and the abundance of microbes on the surface, to measure primary and secondary production and respiration of the supraglacial microbi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Virtual institute on micromechatronics for biomedical industry', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective of the NETMED Project is to set up a Virtual Institute structure aimed at facilitating the access to and the rapid exploitation of RTD results in the field of micromechatronics (MM) for applications in the biomedical sector. NETMED will promote and advance the science and multidisciplinary technologies of MM for the biomedical sector by means of dedicated seminars, training courses, and focused meetings between technology providers and users. NETMED will be a very market-oriented consortium, with a strong problem-solving, application-pulled attitude, aiming at proactively contacting potential users in the biomedical sector, interpreting their needs and providing the best possible services by exploiting MM technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interdisciplinary Centre for Artificial Intelligence in Medicine' (AI4MED).

assistant: **Innovation**

The main aim of this project is to establish a new research center at the Jagiellonian University (JU) in Krakw (Poland). The center will conduct high quality interdisciplinary research connecting artificial intelligence (AI) with healthcare. This group will build on the groundbreaking AI research that is currently conducted at JU. They will apply this work to medical applications, and translate the results into clinical practice. The center will be primarily devoted to research excellence and innovation, but will also operate as a thought leader and an entrepreneurial hub in the medical AI space. The group will be led by an outstanding, internationally recognized physician-scientist with significant achievements in deep learning and medical image analysis. Under his leadership, Polish AI research groups, from JU and beyond, will be able to connect their foundational work with medical experts, which will bring clinicians closer to scientific developments. The ERA Chair holder will be supported by JU faculty and an Advisory Board composed of internationally renowned scientists from top universities across the world, including Harvard University, New York University, Karolinska Institute, and the University of Girona. The center will become an attractive entity and a leader in the medical AI field through research excellence, the improvement of interdisciplinary and international mobility and collaboration, and the creation of attractive courses at the JU. Activities that will lead to this goal are described in 6 Work Packages. In the long-term, work undertaken by the centers members will have wide societal impacts, primarily through the development of next-negation clinical tools, which will lead to better patient outcomes.


**Keywords:** artificial intelligence, deep l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sustainability Impact Assessment: Tools for Environmental, Social and Economic Effects of Multifunctional Land Use in European Regions' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Sustainability of land use in European regions is a central point of policy and management decisions at different levels of governance. Implementation of European policies designed to promote and protect multifunctional land use requires the urgent development of robust tools for the assessment of different scenarios' impacts on the environmental and socio-economic sustainability. The technical objective of SENSOR is to build, validate and implement sustainability impact assessment tools (SIAT), including databases and spatial reference frameworks for the analysis of land and human resources in the context of agricultural, regional and environmental policies. The scientific challenge is to establish relationships between different environmental and socio-economic processes as characterised by indicators considered to be quantitative measures of sustainability. Scenario techniques will be used within an integrated modelling framework, reflecting various aspects of multifunctionality and their interactions. The focus will be on European sensitive regions, particularly those in accession countries, since accession poses significant questions for policy makers regarding the socio-economic and environmental effect of existing and proposed land use policies. SIAT will utilise the statistical and spatial data continuously collected by European and regional agencies. SENSOR will deliver novel solutions for integrated modelling, spatial and temporal scaling and aggregation of data, selection of indicators, database management, analysis and prediction of trends, education and implementation. SIAT will be made available to decision makers at the European and regional level, providing user-friendly interfaces and scientifically sound procedures for the assessment of environmental a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Innovative End of Life procedures for REcycling INTEGRAl welded Al-Li Aerostructures'.

assistant: **Concept**

The REINTEGRA Project focuses on development of dismantling and recycling procedures for integral welded panels, that are under development for new lightweight and cost-effective aircraft structures within the Eco-Design for Airframe (EDA) activity in the Clean Sky programme. This project will investigate different cutting strategies, ranging from cutting only for size reduction to full separation of all materials, and determine their influence on recyclability of 3rd generation of Al-Li alloys. Furthermore, the need to eliminate primer and topcoats and different decoating methods will be investigated. The separated metallic fractions will be processed in a pilot melting facility and the produced metallic alloys characterised in order to establish a ranking in terms of costs, environmental impact and effectivity, that allows to select the best option for recycling Laser Beam Welded (LBW) and Friction Stir Welded (FSW) panels.Also, a recycling compatibility tool (software) will be developed to determine compatibility of different Al-Li alloys, filler material and coatings. First, the theoretical composition of mixed materials per weld length will be calculated and then, this composition will be corrected with experimental data from remelting tests regarding element fading/enrichment. The results will be compared with commercial alloys and the recycling compatibility with primary alloys estimated. The aim is to valorize as much as possible of the valuable alloying elements.The proposed new procedures for dismantling and recycling will be tested both, at coupon level and at live panel dismantling experiment, in which materials will be identified, sorted and pre-treated. The separated metallic fractions will be processed in a pilot melting facility and the produced metallic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Extending fresh food shelf-life through novel plant-derived biofungicides for post-harvest treatments' in the context of a Horizon 2020 call.

assistant: **Objectives**

Today up to a third of all food produced—and almost the 50% of fruits and vegetables (F&V)—perishes before being used with a consequent economic and environmental cost of $1.7 trillion.Somewhere between the 20% and 40% of F&V are lost at postharvest stages, during handling, storage and distribution. Among causes, food spoilage due to fungal pathogens such as molds leads to substantial food waste and an estimated $100 billion of economic losses for producers, retailers and consumers.Traditional control of fungal infection relies on preharvest (field) application of synthetic fungicides, but their use is being progressively banned and efficient natural alternatives are lacking on the market.Moving from this scenario, AgroSustain has identified and patented more than 60 antifungal plant-derived compounds, getting to the formula of a new generation of highly-efficient and cost-effective natural fungicides. Our first product, AgroShelf+, shows an unprecedented fungitoxic efficacy against a wide range of mainly spread fungi, thus preventing postharvest fruit spoilage and extending the F&V shelf-life by a minimum of 7 days. This will allow food retailers and distributors using AgroShelf+ to greatly reduce their food loss costs and improving food quality for consumers.Starting with Switzerland in 2020, AgroSustain plans to expand sales to other EU countries (France, UK and Germany).During this Ph1 project we will optimize the product formulation in order to stress the AgroShelf+ performances targeting specific crops. We will also go through the first round of toxicity tests requested for the certification and regulative approval pathway. A cost-benefit analysis and a deeper market research will also consolidate our pricing strategy and business model. This will pave the way for