RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Host-microbe interactions in health and disease. Interface with the immune system' (HOMIN) under Seventh Framework.

assistant: **Objectives**

HOMIN is designed as an advanced education and research program meant to train junior investigators possessing medical and/or scientific educational backgrounds to become future leading scientists in academic institutions, private companies, or administration.The HOMIN objectives are:1. To provide multidisciplinary and intersectorial scientific education through the study of host-microbe interactions, particularly focusing on immune responses and vaccine development. To this end, HOMIN will provide: Cutting-edge scientific projects in subjects in which the HOMIN partners are international leaders. A collaborative scientific environment, allowing the young researchers to appreciate research in the academic and the private sector, and their connections at the European level. Scientific communication and networking opportunities at the European and International levels.2. To provide an exceptional nurturing environment through an outstanding academic-private sector laboratory network composed of 7 academic partners and 5 companies of different sizes and activities, including 3 SME. The private sector is represented as full partner and associated partner, contributing significantly to training at all the possible levels, from research supervision, to teaching and training organisation. In this environment, young researchers will be aware of biomedical research and its potential industrial applications for human disease prevention and treatment.3. To endow with an array of complementary training on scientific, as well as transferable skills, aimed at developing the young researchers’ creativity, curiosity, adaptability, auto-evaluation capacity, feeling for innovation and discovery application, capacities for team work, for preparing a proposal and for communicating on scien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mid-infrared erbium cascade lasers for the remote detection of carbon dioxide' (ErMIR).

assistant: **Innovation**

Laser sources that can operate in the mid-infrared are increasingly used in applications spanning laser precision surgery to the remote detection of chemicals. Currently, we are experiencing a humanitarian crisis, with the illegal transport of suffering refugees affecting every European country. This project aims to develop a compact and efficient laser source that could potentially help the safe passage of refugees by remotely detecting carbon dioxide that is present when humans breathe.During the course of this project, new laser materials based on erbium-doped sesquioxides will be grown and fully characterised, and developed into highly efficient laser sources. In order to increase the efficiency of erbium-doped lasers operating near 3 µm, these lasers will be made to also emit radiation near 1.6 µm, creating a so-called cascade laser. By using this scheme, the 3 µm transition can be made more efficient since emission of 1.6 µm radiation depopulates its lower laser level, and this scheme further reduces limiting thermal effects, since the 1.6 µm radiation would normally cause heating effects in the laser crystal.This erbium cascade laser will generate 3 µm radiation with more than double the output power that has been previously demonstrated, paving the way for enhanced application-driven experiments. These will be investigated by Q-switching the two-colour laser, and further using this output to generate radiation near 4 µm by means of optical parametric amplification. This now three-colour laser output increases the applicability of such a laser source, allowing for the detection of a larger range of chemical species, but also accurate detection of specific chemicals by measuring the differential absorption of, for example, carbon dioxide at each wavelength. As suc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding Long-term Trends in Multi-pathogen Epidemiology in Africa using Multiplex Serological and Molecular Assays', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Enormous progress is being made in the fight against parasitic diseases such as malaria in sub-Saharan Africa, which is driving a long-term epidemiological shift in the burden of infectious diseases. Until recently, most febrile patients presenting to rural health facilities were presumptively treated for malaria. However, the decline in malaria cases coupled with the roll out of rapid diagnostic tests has revealed a substantial burden of non-malaria fevers. I hypothesise that the predominant disease burden in Africa is changing from parasites to viruses, and that the diversity of infecting pathogens is increasing over time.ULTIMASero aims to investigate long-term trends in the epidemiology of infectious diseases by taking a multi-pathogen approach using multiplex serological and molecular assays, epidemiological studies, and statistical modelling. This will be achieved through four aims: (i) Investigate febrile patients in longitudinal studies in Senegal, Cameroon, and Madagascar; (ii) Develop a multiplex serological assay for viral, parasitic, and bacterial pathogens in Africa; (iii) Create statistical and machine learning tools for multiplex data; and (iv) Implement sero-epidemiological analyses of long-term trends in infectious disease in general populations.The key technological output will be a multiplex serological assay using Luminex bead-based technology to measure antibodies to infectious diseases transmitted in Africa. The assay will test small volume blood samples for antibodies to >300 antigens from >100 pathogens. We will test samples from prospective cohorts of febrile patients to provide an in-depth assessment of the burden of febrile illness, and from 50,000 biobanked samples dating back over 30 years to assess long-term trends in multi-pathogen epidemi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of tools for the analysis of molecular clock and their application for a case of Hepatitis C Virus epidemics with known infection history' to be submitted under Sixth Framework.

assistant: **Abstract**

The strategic directions of multidisciplinary research at the Institute of Oceanology of the Polish Academy of Sciences include genetics and molecular biology of marine organisms, fields of research where progress increasingly depends on expertise in computational biology. This project will allow making the first step in introducing this much-needed expertise in the Institute and indeed in the region, which we hope will benefit several projects at the Institute (molecular systematics of marine invertebrate s, population genetics of fish and molluscs, marine microbiology). However, considering the short timeline, the utility of tools developed during the project will first be tested on a dataset of Hepatitis C Virus sequences obtained from an epidemic with kn own infection history. These data allow constructing a true phylogenetic tree with extensive temporal information, as the times for both the external nodes and crucial internal nodes are known. HCV displays one the highest rates of evolution detected in an y life form (reaching 10-2 substitutions/site/year. Moreover, extreme heterogeneity of substitution rate is observed in some of the regions of HCV genome. The project will concentrate on resolving the following issues: (1) the level of heterogeneity of the rate of substitution among sites, (2) the use of complex models (for example, models which allow multiple substitution matrices) for possibly better description of the data,  (3) the effects of the presence of positive selection on the molecular clock,  (4) the nature of amino acid substitutions that occur, especially in the context of the quasispecies hypothesis and the possibility of multiple infections. By analysing sequences coming from a major human pathogen, we hope to provide insight into the molecular bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Dynamic Resilience Assessment Method including combined Business Continuity Management and Cyber Threat Intelligence solution for Critical Sectors'.

assistant: **Innovation**

The scope of DYNAMO is to combine the two fields of business continuity management (BCM) and cyber threat intelligence (CTI) to generate a situational awareness picture for decision support across all stages of the resilience cycle (prepare, prevent, protect, response, recover). Professionals of different backgrounds will work together with end-users to develop, refine and combine selected tools into a single platform. In alignment to end-user needs, human factors, high ethical standards and societal impacts, DYNAMO includes the following goals:Resilience assessment as basis for BCM- An assessment with different levels of detail offers with varying existent data a fast or detailed evaluation of the investigated sector and helps to identify critical processes.- End-user data will be integrated to measure determined performance targets. With respect to the functional description, AI-based approaches will be used for a deeper understanding and potential self-learning of the interconnected process.- The results generate knowledge concerning susceptibility and vulnerability of the investigated sector. - The solutions support the BCM with respect to the five resilience phases. Leveraging CTI- CTI will be improved with respect to existing solutions (H2020 ECHO, PANACEA).- The H2020 Early Warning System (EWS) will be extended and integrated. A Malware Information Sharing Platform (MISP) will be used to raise the situational awareness between different security actors.- The CTI approach deliver data that will be integrated into the resilience and BCM approach. The use of AI will support the development. Solutions will be integrated with the Cyber Knowledge Graph to visualize the analysis of threat intelligence.The DYNAMO platform will be able to collect organization’s skills dat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ROBUST NUMERICAL UPSCALING OF MULTIPHYSICS PHENOMENA IN DEFORMABLE POROUS MEDIA' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main goal of this research is to develop, analyze, and implement robust numerical upscaling algorithms for emerging multiphysics problems of flows in deformable porous media. The physical problem under consideration at the fine scale is the strongly coupled, nonlinear Fluid-Structure Interaction (FSI) problem subject to large pore-level deformations and/or a nonlinear hysteretic solid. Moreover, microstructures with a continuum distribution of poorly separated length scales will be considered. Novel iterative upscaling algorithms will be used to develop coarse scale models for such media. The research will result in a Multiscale Finite Element Method, which bypasses the explicit homogenization step by building fine-scale information directly into a coarse-scale computational grid. The approach allows accurate numerical simulations at several tightly coupled scales, with the fine scale physics being properly incorporated at the coarser scales. A highly efficient and scalable parallel implementation will be pursued that will allow numerical simulations of realistic problems. The proposed algorithms will be used for pilot numerical simulations of cutting edge problems in multiscale hydro-mechanical modeling of bone tissue and in automotive filter design. Moreover, design of novel temperature and pressure-controlled flow regulators with applications to filters, catalytic converters, and separators can only become possible with such advanced tools for multiscale simulations. The work will also have long term impact in development of upscaling methods for modeling and simulations of emerging multiphysics problems such as carbon sequestration, waste water management or unconventional oil recovery. It also fulfills the aim of reintegrating the researcher. It covers priority
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SArkisov Program in HIgher Dimension, over Imperfect fields and for birRegulous maps' (Saphidir).

assistant: **Innovation**

A fundamental goal of Algebraic Geometry is to classify algebraic varieties up to isomorphism. This is extremely hard, already for surfaces, and open in general. It has become clear that we can only hope for a classification up to birational maps, that is, isomorphisms between dense open sets. Understanding birational maps is therefore a key step towards the classification of algebraic varieties. For one of the largest families of algebraic varieties, so-called Mori fibre spaces, any birational map between any two of them is composed of special birational maps called Sarkisov links. For surfaces over nice fields, Sarkisov links are well-understood, but little is known about them in dimension three or higher, over any field.  The understanding of Sarkisov links will mean an enormous advance in the study of birational maps and a substantial leap towards a classification of a large family of algebraic varieties.  The very ambitious aim of this project is to describe all Sarkisov links completely in any dimension and in several non-classical settings in terms of base-locus, contracted hypersurfaces and induced rational map on the bases of the implicated Mori fibre spaces. If achieved, it will revolutionize the study of birational maps and provide new exciting tools to determine classes of algebraic varieties in several settings. In dimension three and higher, already the classification of Sarkisov links over the field of complex numbers is extremely ambitious. Another very difficult task is to classify Sarkisov links over a field of positive characteristic, as the geometry of algebraic varieties over such fields is even more challenging than it is over the field of complex numbers. The Minimal Model program, a major active research area in Biratonal Geometry, has made treme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coordination-Activation Chemistry of Ammonia-Boranes at Multiple Metal-Metal Bonded Complexes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

With more than 65% of the refined petroleum products exhausted by transportation in the developed countries, is vitally important to promote a shift away from carbon-based fuels and towards environmentally friendly energy sources. In this sense, hydrogen has the potential to be a clean (producing water) and source-independent energy carrier. A type of compounds which has attracted much attention in recent years as new materials for hydrogen storage are the ammonia-borane and related molecules, for which hydrogen loss is favoured over dissociation under most conditions.The primary purpose of this project is to study the coordination/activation chemistry of ammonia-borane and related organic molecules when reacted with dinuclear transition metal complexes exhibiting multiple metal-metal bonds. The interest of the project is based on: a) the absence of previous studies of the coordination chemistry of AB´s on multiply bonded dinuclear complexes, b) the interesting dehydrogenation processes of AB´s when reacted with mononuclear transition metal complexes, and c) the possible utility of this catalytic dehydrogenation of AB´s not only for hydrogen production processes, but also for the incorporation of B–N species to unsaturated organic molecules.Apart from the novelty of the research results, this project will provide a solid platform from which the applicant can begin a fully independent research career. It will enable him to carry out and lead an internationally competitive research programme in an unexplored area, gaining further experience in teaching, oral and written communication and networking. Also, timeliness will be a critical factor, with results written up expeditiously to ensure that Europe maintains a lead position in this research area.The acceptance of the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identification of genes activated by the roralpha transcription factor: a gene implicated in age related degenerative pathologies.' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The identification of genes regulated by RORAlpha will represent an understanding of its action on the molecular level and in the phenotypes seen in the staggered mutant. We shall use microarray analyses and an inducible ER fusion protein to compare gene expression between a variety of RORAlpha + and - systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '6th International Conference on Computing in Economics and Finance' to be submitted under Fifth Framework.

assistant: **Abstract**

This conference is organized every year by the Society for Computational Economics. The objective of the Society is to promote methods in economics and finance. The presentations cover both quantitative and qualitative methods for economics, finance, and decision making- They include, but are not limited to, the following subjects: computational tools for linear and nonlinear systems, stochastic control, automatic differentation, nonlinear model-solution methods, mathematical programming algorithms, variational inequality and other algorithms for computing equilibria, neural networks, computability and complexity theory among others. The issues covered by the papers on financial topics are: complex options modelling, computational asset-liability issues, income securities, risk assessment simulation, network pricing, artificial intelligence, among others.To pursue these objectives, the Society sponsors an annual scientitic conference, generally to be held in The summer months. The conference shall be structures, to include the research interest of all members of the Society to encorage their participation. The site of the conference alternates, between Eastern And Western Hempisphere locations to promote intemational participation. This conferences are called 'world meetings. With this conference we plan to bring together the top of young European researchers to discuss recent Developments in the field of computational economics as their implications.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00398-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Predicting Cardiotoxicity Induced by Kinase Inhibitors: From Systems Biology to Systems Pharmacology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Kinase inhibitors (KIs) are a major class of highly effective anti-cancer drugs. Unfortunately, therapeutic use of KIs is often associated with cardiotoxicity (CT), a serious adverse condition which limits their use. This fellowship aims to develop mathematical systems pharmacology models for KI-induced CT. These models will be used to identify predictive CT signatures that will allow to decrease CT risk of new KIs. This innovative multi-disciplinary approach consists of integrating mathematical systems pharmacology modelling, with state-of-the-art experimental data generation. To this aim, KIs with different magnitudes of CT will be selected based on clinical adverse event databases. Human cardiomyocytes derived from pluripotent stem cells will then be treated with the selected KIs and in combination with CT modifying drugs. The effect of these treatments on changes on untargeted mRNA and protein expression will be measured and then analyzed using network modelling. This approach allows identification of key regulatory proteins. The selected proteins will then be quantified over time along with cardiomyocyte health markers. With this data, dynamical models will be developed to capture the relationship between exposure to KIs and the effects on protein expression and cardiomyocyte health over time. Ultimately these models will allow generation of predictive network-based dynamically-weighted signatures for CT.The fellow aims to establish himself as independent researcher in systems pharmacology. Training in state-of-the-art computational and experimental technologies at the leading systems pharmacology group at Mount Sinai in New York will fundamentally strengthen and broaden the experience of the fellow. This project will significantly contribute consolidate the career