RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Open transPREcision COMPuting', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Guaranteed numerical precision of each elementary step in a complex computation has been the mainstay of traditional computing systems for many years. This era, fueled by Moore's law and the constant exponential improvement in computing efficiency, is at its twilight: from tiny nodes of the Internet-of-Things, to large HPC computing centers, sub-picoJoule/operation energy efficiency is essential for practical realizations. To overcome the “power wall”, a shift from traditional computing paradigms is now mandatory.OPRECOMP aims at demolishing the ultra-conservative “precise” computing abstraction and replacing it with a more flexible and efficient one, namely transprecision computing. OPRECOMP will investigate the theoretical and practical understanding of the energy efficiency boost obtainable when accuracy requirements on data being processed, stored and communicated can be lifted for intermediate calculations. While approximate computing approaches have been used before, in OPRECOMP for the first time ever, a complete framework for transprecision computing, covering devices, circuits, software tools, and algorithms, along with the mathematical theory and physical foundations of the ideas will be developed that not only will provide error bounds with respect to full precision results, but also will enable major energy efficiency improvements even when there is no freedom to relax end-to-end application quality-of-results.The mission of OPRECOMP is to demonstrate using physical demonstrators that this idea holds in a huge range of application scenarios in the domains of IoT, Big Data Analytics, Deep Learning, and HPC simulations: from the sub-milliWatt to the MegaWatt range, spanning nine orders of magnitude. In view of industrial exploitation, we will prove the quality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An innovative dental implant with osteoinductive properties by means of bioactive sol-gel coating' (SolDent) targeting Horizon 2020.

assistant: **Abstract**

In the treatment of edentulous patients with dental implants, there are usually strict patient selection criteria based on well-recognised risk factors that are associated with poor bone-forming activity, such as diabetes, smoking or metabolic bone disorders. Therefore, many patients remain untreated with dental implant clinical practice. Additionally, the expectations of both surgeons and patients of shortening the recovery phase of the dental implant treatments have led Ilerimplant –a well-recognised Spanish manufacturer of dental implants with an excellent worldwide network of distributors– to develop an innovative osteoinductive dental implant by means of a biodegradable coating. The osteoinductive properties, one of the most desired in the last generation of dental implants but not reached yet, have been obtained by a bioactive organic-inorganic hybrid material specially tailored for this purpose by a sol-gel coating process.Ilerimplant’s overall goals with this innovation project are to industrialise and introduce in the market a new generation of osteoinductive dental implants based on this sol-gel coating (SolDent). Taking into account that the global dental implant markets are continuously growing and that SolDent will be the unique product in the market with effective osteoinductive properties, Ilerimplant expects to make a qualitative leap in market shares and sales with an eminently European and international approach.Firstly, we will conduct a practical and economic feasibility study in Phase 1 in order to assess the industrialisation process, regulatory issues and commercialisation strategy, ending with the elaboration of a comprehensive business plan. In Phase 2, we will address industrialisation and clinical trial in order to achieve full commercialisati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nanometer scale induced structure between amorphous layers and crystalline materials' (NANOAM) under Fifth Framework.

assistant: **Objectives**

Interfaces between amorphous/glassy layers and crystalline materials are playing an increasingly important role in the properties of manufactured ceramics and composites , especially as they move towards the nanometer scale . Recent research has revealed previously unknown physical , electronic and chemical phenomena occurring at these interfaces. The nanometer-scale structure at the interface is now believed to cause gradients in order and bonding that influence macroscopic physical properties such as fracture, high temperature creep, sintering, electrical conductivity, dielectric response and chemical reactivity. The goal of this project is to achieve a complete computational and experimental description of the structure and basic properties of crystal/glass interfaces, for the purpose of improving materials properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unravelling the mechanisms that allow endosymbionts to make themselves at home within hosts, from transfer to transit.' (2014-2020).

assistant: **Innovation**

Endosymbiotic bacteria are usually not infectious, they have been thought to exclusively transfer vertically from the host mother to her offspring. Consequently we do often observe congruence between the phylogenetic trees of endosymbiotic bacteria and their host species, but not always. Evidences for the horizontal transfer of endosymbiotic bacteria between highly divergent host species have recently been accumulating, especially from studies in Insects. My own research on this topic led me to hypothesise that endosymbiotic strains not transferring horizontally may have lost the ability to do so and to establish into naïve hosts, contrasting to strains found in divergent host species. Instead of transferring, these strains would transit from a generalist state, able to jump and establish into naïve hosts, towards a more specialist state found in only few host species.Using Wolbachia bacteria-butterfly host associations and a multidisciplinary approach, I aim at (I) testing the evolutionary relevance of horizontal transfer of symbionts, (II) phenotypically characterizing generalist and specialist symbionts, and (III) identifying the molecular bases to the establisment of symbiosis.  The novelty of this project lies into solving the dilemma associated to the endosymbiotic lifestyle: to maintain the mechanisms allowing transfer between hosts or to transit towards a specialised relationship with the host. ‘Host Sweet Home’ will to unravel the evolutionary history, and the constraints and outcomes of endosymbiosis. I will produce a large amount of genetic data, which analysis will result in highly significant research in the field of symbiosis, with a potential impact beyond the field of Evolutionary Ecology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'TRAVALler and traffic information systems: GUIDElines for the enhancemnt of integrated information provision services' (TRAVEL-GUIDE).

assistant: **Concept**

TRAVEL-GUIDE will develop guidelines concerning information provision by traffic information and traffic management system. The project will investigate and assess the needs of drivers in terms of content, presentation, availability, reliability, timing and hierarchy of the e information provided, conduct relevant tests and suggest new methods in order to meet user needs and requirements raised by the development of the Trans-European Networks. New methods of information provision and presentation will be developed in order to increase information functionality and decrease the driver workload taking into account the specific requirements of special driver groups, including foreign drivers. The work will improve the credibility and reliability of traffic information systems, enhance their effectiveness in relation to network utilisation, traffic safety and environmental protection and promote relevant market application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Development of novel analysis techniques for the search of new states of matter in ultrarelativistic nuclear collisions'.

assistant: **Innovation**

I propose to work with the group of Professor Reinhard Stock in IKF, Frankfurter in the analysis of the data of the heavy-ion NA49 experiment which studies central collisions of 208Pb+Pb at 160 GeV/nucleon. I am interested in studying the high energy density state created in these collisions for a brief instant of time and search for the Quark-Gluon-Plasma that may have been formed. For this I intent to realise the concept of the full event-by-event analysis implementing sophisticated methods for the precise analysis of complex events and developing tools that allow the correlation of multiple observables in the processing of huge amount of data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An innovative, minimally invasive medical device used for treatment of Benign Prostatic Hyperplasia symptoms' to be submitted under Horizon 2020.

assistant: **Abstract**

Benign Prostatic Hyperplasia (BPH), or prostate enlargement, is one of the most common urological diseases among men. As the prostate enlarges with the age, it presses on and blocks the urethra, causing bothersome urinary symptoms. Over 70% of men in their 60s have symptoms of BPH 1, and 80-90% of men over 80 year old. BPH affects around 200 million men worldwide. The current methods present a significant unmet need for minimally invasive or less invasive BPH therapy as a less costly, more tolerable, and comparatively safe alternative to drugs and invasive surgery, which carry greater risk of undesirable side effects and complications.ClearRing is a revolutionary treatment of BPH symptoms, based on a pre-shaped implant and a dedicated delivery system. The ClearRing solution is the only minimally invasive system for BPH which is implantable inside the prostate with 0% chance of migration or encrustation. It puts ProArc in a unique position as a first company providing significantly improved health conditions and quality of life. Its rapid procedure enables hospitals to get patients in and out more quickly, creating a better patient experience as well as a more efficient management of medical resources. The minimally invasive procedure reduces the range and severity of side effects allowing patients to resume their normal lifestyles potentially twice as fast as the current standard operation procedure. Furthermore, it preservers sexual function.Overall objective of ProArc is to introduce a BPH treatment which is effective, affordable and with no side-effects, therefore men seek for the treatment instead of watchful waiting for the worsening. Whereas, the key objective of the project is to validate the ClearRing safety and efficacy for BPH treatment through a randomized cl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'LABOUR MARKET CHANGES AND WELFARE PERSPECTIVES IN EUROPE' under Fifth Framework.

assistant: **Concept**

Labour market trends and welfare systems are currently among the most important issues debated in the European Union, due to the deep social and economic changes that are taking place. So far, these subjects have been analysed separately, generally neglecting the mutual connections. This project aims at filling in this gap, scrutinising the effects of the emerging atypical working profiles (self-employment, temporary work, tele-work) on the welfare systems in several EU countries. The data, gathered from heterogeneous sources and structured by means of standardised indicators, will be collected in a central database, for a comparative prospect of the current situation and a projection of the expected trends. The final results will be presented at an International Conference to be organised at this purpose.The project outcome will be addressed to the institutions involved in the preparation and actuation of policies supporting employment and social protection, both at national and European level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CommBeBiz - Communicating and Bridging BioEconomy Research to Business' (CommBeBiz).

assistant: **Concept**

Communicate and Bridge BioEconomy Research to Business   The overall objective of the CommBeBiz project is to contribute to the improvement of sustainable living conditions through the most effective and responsible use of our biological resources. This will be achieved through designing, delivering, assessing & evaluating a Pilot scheme (BeBizPilotPlan), that provides tailored and targeted support and co-ordination activities across all Member States. The Pilot will bring KBBE funded research projects in FP7 and Horizon2020 programmes together with bioeconomy research, knowledge transfer, social innovation, policy development and communication experts, SMEs and entrepreneurs to drive innovation and exploitation faster for the environmental good and commercial benefit. The full results of the BeBizPilotPlan will be published in the BeBizBlueprint. The project will use a tailormade approach to the segments of the bioeconomy : agriculture, fisheries, food, forestry and biotechnology. CommBeBiz will work collaboratively on the FP7 database with 'Allied Projects' BioLinx and ProBio utilising the Heads of Agreement document agreed between us (July 2015).


**Keywords:** Fast tracking EC funded Bioeconomy research projects to commercial, social & policy innovation via evaluated pilot programme of assessment, networking, mentoring, training, tailored support
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biased Artificial Intelligence: Openness, innovation and the remaking of mental health' under Horizon 2020.

assistant: **Concept**

Following trends to design Artificial Intelligence (AI) for Good,  (a plea to develop AI in ways addressing pressing problems that face humanity), the focal question we will address is: What is the proper combination of open and proprietary elements in AI innovation in the field of mental health in light of the need to design a system that both promotes innovation and is compatible with the ideals of human dignity, fundamental rights and freedoms, and cultural diversity? Our concern in the context of mental health in particular is that proprietary AI may reproduce gender and racial stereotypes, which in turn may reinforce social stigma and raise a barrier to proper diagnosis and treatments. On the other hand, the present research does not entertain a model of innovation where the proprietary stands in opposition to the open. Rolling back private property does not necessarily favour the weak over the strong. To this effect, we propose to conduct qualitative research to identify public and commercial demands in order to rethink the governance of innovation in AI, focusing in particular on mental health. Participant observation and Interviews with key stakeholders will be conducted to elicit their views, taking into account not only economic but also ethical aspects (diversity, rights and freedoms). The governance question needs to take into account public demands that are technically feasible and at the same time commercially viable in the AI area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Digital readout of protein detection via super rolling circle amplification of DNA tags' (DigiRead).

assistant: **Innovation**

This project will serve to evaluate market opportunities of a newly invented technology for digital detection of reporter DNAstrands in protein analysis.The purpose of my ongoing ERC project ProteinSeq is to develop technology and reagents for parallel, sensitive andspecific targeted protein analyses in plasma samples, lysates, etc. An important limiting factor for the broader adoption ofour technology is the cost and throughput of next generation sequencing and realtime PCR to read out the identities andlevels of reporter DNA strands that reflect the amounts of proteins in a sample.In the course of the ERC project we have invented and patented a technique to greatly enhance each of the reporterstrands to prominent DNA objects that can be easily detected, identified and counted by fluorescence microscopy withautomated image analysis or through flow cytometry. We refer to this highly specific technique as super rolling circleamplification or sRCA, and it involves two generations of RCA and combinatorial fluorescence detection of the largeproducts, each composed of hundreds of thousand repeats of specific tag DNA sequences.In the proposed PoC project we will position our new technology against other readout techniques such as next gensequencing, realtime PCR and microarrays by identifying Needs, Approach, Benefits, Competition for sRCA. Potential endusers will be contacted to establish customer requirements, and we will evaluate freedom to operate and the extent ofmonopoly for our invention. We will also specifically investigate means to distinguish many sRCA products by combinatoriallabeling schemes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pan-cancer functional evaluation of non-coding DNA mutations' under Horizon 2020.

assistant: **Concept**

The functional evaluation of cancer mutations has been largely restricted to the protein-coding genome, due to our lack of (i) whole-genome sequence data for cancer genomes, and (ii) knowledge about the function of the non-coding genome. However, more recently the function of the non-coding genome has been largely annotated by the ENCODE project, where large consortia are profiling thousands of tumor and matched non-neoplastic tissue samples at the genomic, proteomic and epigenomic levels.Previous studies have shown that (i) over 90% of the disease-associated loci identified with genome-wide association studies (GWAS) lie within the non-coding genome, and (ii) non-coding mutations are frequent in cancer. Nevertheless, few studies have evaluated the role of genetic variation in the non-coding genome in cancer development and progression, and therefore, the landscape of non-coding mutations in cancer remains uncharted territory. Moreover, there are no studies yet relating variation or mutations within the non-coding genome to the sensitivity to drugs, and this is hence the purpose of the work described here.Using genome-wide sequence, epigenomic, transcriptomic, proteomic and eQTL data from (i) over 2,000 whole cancer genomes, (ii) over 10,000 tumor and matched non-neoplastic tissue samples spanning 25 tumor types, and (iii) the ENCODE project, I aim to build a comprehensive map of non-coding mutations across the most prevalent cancer types. Subsequently, this map will be integrated with pharmacological profiles of small molecules in predictive models, thus allowing to identify genetic variants and mutations associated to drug efficacy and resistance across cancers. This work will help unravel the impact of non-coding mutations on genome regulation and gene expression, to