RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a coherent approach to human biomonitoring in Europe' in the context of a Sixth Framework call.

assistant: **Objectives**

ESBIO aims at developing a coordinated approach for human biomonitoring (HBM) with focus on children in Europe, in line with Action 3 of the EU E&H Action Plan by providing strong scientific support for the pilot project to be launched end 2006. The project proposal aims to overcome specific deficiencies in EU HBM in particular by generating significant added value with:- An updated and extended inventory of EU HBM activities and data bases, ensuring relevant activities and stakeholders to be integrated in the development of a coordinated approach and creating a platform for exchange;- Proposals - for a coordinated approach and for a pilot study - for possible objectives, target pollutants and appropriate markers, study design and methods for collection, analysis and evaluation of data, protocol for laboratory coordination;- A concept for integration of biomonitoring with environmental and health monitoring and for translation of HBM results into a response system;- Guidelines for ethical practices;- Guidelines for communication and dissemination of results;- Strategies for wider communication to stakeholders;- An assessment of socio-economic consequences and costs of various alternatives, including a concept to improve cost efficiency;- A concept for coordination, evaluation and follow up of a EU pilot project;- A systematic overview and evaluation of the sensitivity and utility of biomarkers in perspective of a EU pilot project;- A strategy for synergism between environmental health research and a pan EU HBM surveillance network.Members of ESBIO actively participated in the elaboration of the EU E&H Strategy and are active in EU institutions playing a major role in HBM research and surveillance focussing on children. ESBIO is geographically well balanced, involves 62%
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Elucidation of DNA Damage Response mechanisms in human normal and leukemia stem cells'.

assistant: **Concept**

Life-long blood regeneration is critically dependent on self-renewing multipotential hematopoietic stem cells (HSCs). HSCs’ nearly unlimited self-renewal potential and lifetime persistence in the body, in contrast to the committed progenitors (CP), signifies the need for HSCs genome integrity tight control. Indeed, accumulation of unrepaired DNA damage in HSCs is associated with bone marrow failure and accelerated leukemogenesis. Our recent findings revealed for the first time striking differences in DNA Damage Response (DDR) characteristics between HSCs and CPs isolated from umbilical cord blood. Human HSCs exhibited attenuated DNA repair, persistent DDR signaling and increased apoptosis relative to CPs. Yet, the molecular basis and physiological significance of these HSC-specific DDR characteristics remain unexplored.To bridge the gap in this highly significant knowledge I propose the following research objectives: 1) To analyze in details DDR signaling in the highly purified HSC and CP subsets isolated from physiologically distinct developmental stages of human hematopoiesis: fetal, neonatal and adult; 2) To identify  functional regulators engaged by genotoxic stress in normal and leukemia stem cells. To address these questions I will employ multi color flow cytometry, functional genetic screens, mRNA/microRNA expressional profiling, clonal in vitro assays and, most importantly, in vivo repopulation assays of human normal HSC and leukemia-initiating cells. Furthermore, we will pursue a novel DNA repair fluorescent reporter strategy to examine DNA repair activity and fidelity in live human HSC.This original study will form the foundation for my long-term goals of identifying regulators of DDR in human HSCs and in leukemia-initiating cells, revealing mechanisms utilize
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel Strategies to Fight Child Sexual Exploitation and Human Trafficking Crimes and Protect their Victims' (HEROES) under Horizon 2020.

assistant: **Objectives**

Trafficking of human beings (THB) and child sexual abuse and exploitation (CSA/CSE) are two big problems in our society. Inadvertently, new information and communication technologies (ICTs) have provided a space for these problems to develop and take new forms, made worse by the lockdown caused by the COVID-19 pandemic. At the same time, technical and legal tools available to stakeholders that prevent, investigate, and assist victims – such as law enforcement agencies (LEAs), prosecutors, judges, and civil society organisations (CSOs) – fail to keep up with the pace at which criminals use new technologies to continue their abhorrent acts. Furthermore, assistance to victims of THB and CSA/CSE is often limited by the lack of coordination among these stakeholders. In this sense, there is a clear and vital need for joint work methodologies and the development of new strategies for approaching and assisting victims. In addition, due to the cross-border nature of these crimes, harmonisation of legal frameworks from each of the affected countries is necessary for creating bridges of communication and coordination among all those stakeholders to help victims and reduce the occurrence of these horrendous crimes. To address these challenges, the HEROES project comes up with an ambitious, interdisciplinary, international, and victim-centred approach. The HEROES project is structured as a comprehensive solution that encompasses three main components: Prevention, Investigation and Victim Assistance. Through these components, our solution aims to establish a coordinated contribution with LEAs by developing an appropriate, victim-centred approach that is capable of addressing specific needs and providing protection. The HEROES project’s main objective is to use technology to improve t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Living with Hard Times: How European Citizens Deal with Economic Crises and Their Social and Political Consequences' (LIVEWHAT), addressing dissemination and exploitation.

assistant: **Impact**

The proposed research deals with citizens’ reactions to economic crises and their social and political consequences. It examines in particular the ways in which European citizens have reacted to the crisis that, at different degree of intensity in different countries, struck Europe since 2008, but also how they deal with economic crises and their consequences more generally. We examine both individual and collective responses by citizens, both the “private” and the “public” dimensions of such responses, and both political and non-political responses. In addition, while the focus of the research is on citizens’ responses, we also examine policy responses so as to have a baseline for assessing citizens’ reactions to crises. The project has three main objectives: (1) to provide systematic evidence of the ways in which European citizens react to economic crises and their social and political consequences, both individually and collectively; (2) to advance knowledge on the connections between individual factors, contextual factors, and the ways in which European citizens react to economic crises and their social and political consequences; and (3) to suggest a number of good practices as to how to deal with economic crises, both at the social and political level, through which their negative consequences on European citizens can be avoided or limited. The project’s objectives are addressed by means of six main types of data and methods: (1) the creation of a cross-national comparative dataset on economic, social, and political indicators; (2) an analysis of policy responses to crises; (3) an analysis of collective responses to crises in the public domain; (4) an analysis of individual responses to crises by private citizens; (5) experiments designed to assess causal effects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Excellence in the research area of Combating and evaluation of mixed biofilms.' in the context of a Horizon 2020 call.

assistant: **Objectives**

CEMBO aims at developing Excellence in the Research Area of Combating and Evaluation of Mixed Biofilms. This will be achieved by twinning the Comenius University in Bratislava (CU), Faculty of Natural Sciences (FNS) with outstanding EU institutions with high expertise in the areas of anti-biofilm strategies and biofilm visualisation. The team from FNS CU has an established scientific reputation and has exploited its expertise in the development of novel future technologies. The goal of the CEMBO project is to provide CU the opportunity to learn from partners, strengthen the research potential on CU with emphasis on building a Centre of Excellence in the field, concerning different aspects of mixed biofilms spanning from basic research over dissemination of knowledge to possible applications in industry. CEMBO will allow the excellence development required for a consolidated strategic research approach and designing a set of guidelines including methodological route implemented through scientific events leading to exploitation and commercialization of the results that will have a strong regional, national, and European impact. The objectives are in line with the specific challenge and scope of the topic H2020-WIDESPREAD-2020 of the Twinning call, addressing networking gaps and deficiencies between the research institutions of the Widening countries and internationally-leading counterparts at EU level. This challenge is addressed by twinning CU with 2 leading EU research institutions: Academic Medical Center at the University of Amsterdam, The Netherlands, a global leader in the development and invention of novel antimicrobial strategies to combat biomaterial-associated infections; Charité Universitätsmedizin Berlin (CHAR), Germany, one of the largest and most prestigious
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ve-Wa:Vegetation effects on water flow and mixing in high-latitude ecosystems–Capability of headwater catchments to mediate potential climate change' (VEWA) under Seventh Framework.

assistant: **Objectives**

Our ability to predict consequences of climate change on the physical, chemical and biological characteristics of water resources in high-latitude uplands is a formidable challenge. These regions are highly sensitive to climate induced changes as small differences in temperature determine the status of frozen ground, the state of precipitation, and the magnitude and timing of snow accumulation and melt. Recent findings in mid-latitude regions suggest that there exist “two water worlds” – mobile water expressed in the stream and tightly bound water represented by plant water – which means that a substantial proportion of precipitation that infiltrates the soils becomes isolated from discharge to the streams, indicating that the composition of stream water alone is insufficient to understand routing and transit times of water in catchments. These findings challenge the core assumptions in our perceptual models of how we think biophysical systems work and how we make predictions of water partitioning of how inputs of water are evaporated, stored and reach the streams. High-latitude headwater catchments are characterised by lower evapotranspiration, consequent lower soil moisture deficits and different seasonality than mid-latitude sites. This interdisciplinary proposed project will address novel questions on vegetation-water linkages by using isotopic tracers in different waters as ""fingerprints"" across different spatial scales along a climate gradient as a precursor to understand future response to change in high-latitude upland catchments. The proposed project will – for the first time - examine the mechanisms of water storage, transmission and release and possible implications of climate change in high-latitude ecosystems along a cross-regional transect. Such geograph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Judges’ Off-Bench Activities: Evidence and Theory on Judicial Politics from Africa.'.

assistant: **Objectives**

Off-Bench adopts an innovative approach to the study of judges and judicial politics. Rather than focusing on judicial rulings (the mainstay of academic study) it undertakes the first systematic study of what judges do outside of their courtrooms as part of their official duties and public engagements (hereon off-bench activities), why, and with what impact. This politics project adopts this approach for five reasons: off-bench activities are inherently political; judges engage in a wider range of off-bench activities than has hitherto been recognised; what judges do off-bench is highly revealing of their role understandings; what judges do off-bench matters for the roles that they play both on and off the bench; and judges are critical political actors who can help to promote or undermine the rule of law, accountability, and human rights. The project focuses on contemporary Africa as a most likely case for such off-bench significance and to build theory from the Global South. To facilitate the complex mix of qualitative and quantitative research required to map and then analyse off-bench activities the project will undertake extensive research in two countries. Kenya and Zambia are selected as most similar cases that display different levels of off-bench activism and judicial independence. To test theory developed and evaluate the broader applicability of findings the project will conduct additional research in five ancillary cases – Ghana, Rwanda, Senegal, South Africa, and Uganda – selected for differences in levels of authoritarianism, conflict, and off-bench activities, and common and civil law traditions. This ambitious project will transform how we study and understand the political role, strategies, and significance of this critical democratic actor and make gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Lead Optimisation of Novel Androgen Receptor Small Molecule Modulators - Improving Treatment of Prostate Cancer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

One of the traditional approaches for the treatment of prostate cancer is the administration of steroid-derived Androgen Receptor (AR) antagonists. These treatments show significant side effects due to their high dosing requirements. In a novel intervention approach Molecular Design Group (Trinity College Dublin), has used a variety of computational drug discovery techniques to analyse a recently identified, non-steroid AR protein binding site, termed the activation function 2 (AF2) site.  The goal of this proposal is to perform lead optimisation for the development of new drugs that combat prostate cancer in a different way, circumventing the observed resistance.The project will be implemented at Trinity College Dublin (TCD), Ireland's leading research University, supervised by Dr David Lloyd and Dr Darren Fayne, from Molecular Design Group (TCD), on the computational methodologies, Prof Mary Meegan, from the School of Pharmacy and Pharmaceuticals Studies (TCD), on the synthetic methodologies and Prof Clive Williams, from the School of Biochemistry and Immunology (TCD) on the biological assays. The responsibilities of the experienced researcher, Dr. Fernando Blanco, within the project will focus on the rational computational design and synthesis of new potential pharmaceuticals, receiving multidisciplinary training combining computational strategies, synthesis and biological assays, as well as other fundamental aspects (managing and administering of a research programme) related to strengthen the abilities of the Dr. Blanco to become a leading independent researcher in the field.The completion of the present project is a major step in the research career of Dr. Blanco to successfully reach a position of professional maturity. In addition, the development of new small m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ethical dilemmas due to prenatal and genetic diagnostics interdisciplinary assessment of effects of prenatal and genetic diagnostics on couples in different European cultures' to be submitted under Sixth Framework.

assistant: **Abstract**

Achievements in genetic research produce ethical dilemmas which need to be subject of reflection and debate in modern societies. Ethical dilemmas are seen as situations in which a person has a strong moral obligation to choose each of two alternatives for action, but cannot fulfil both. Denial of ambivalences that ethical dilemmas arouse constitutes a threat to societies as well as to individual persons.The study tries to investigate these dilemmas in detail in a field which seems particularly challenging: prenatal diagnostics (PND). PND confronts women and their partners with ethical dilemmas regarding: the right to know and not to know, the responsibility for their unborn child, about its life and death and, for its well- being even with abnormalities and sufferings. An important aspect is the conflict of individual beliefs and obligations and those of society's specific cultures. These dilemmas have not received full attention in our societies and often remain latent, creating a source of distress for couples and may be a burden on the relationships. However, more research is needed to identify those with vulnerability to psychopathology as a consequence to abortion after PND results or to giving birth to severely handicapped.The study will describe existing care systems across participating centres. Data is collected in 2 sub-studies. All results are integrated into a discourse on ethical dilemmas. Study (A) recruits two groups of couples (positive/negative PND, n=300). Experiences with PND and connected dilemmas will be explored. Results will be discussed in interdisciplinary research groups. Study (B) interviews therapists and their patients who showed severe psychopathologies as reactions to the dilemmas mentioned. Results of the study will be discussed with part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Shaping the transcriptome through autophagy' (TranscriptShape), addressing dissemination and exploitation.

assistant: **Impact**

In the face of environmental stress, autophagy plays a crucial role in stress adaptation through the maintenance of cellular homeostasis. While extensively studied for its ability to degrade proteins, pathogens, and organelles, the potential of autophagy to degrade RNA remains largely unexplored. Recent findings from my team uniquely reveal that specific subsets of RNA are selectively sequestered and degraded by autophagy in a stress-responsive manner. However, the molecular mechanisms driving this process and its biological implications remain unknown. Based on our preliminary results, I hypothesize that autophagy represents a previously unrecognized, highly regulated RNA decay pathway capable of dynamically shaping the transcriptome in response to cellular stress.Here, I propose a comprehensive approach to investigate autophagy's impact on transcriptome remodeling in response to hypoxia and UV irradiation in cellular models and during melanoma development in mice. To this end, I will integrate state-of-the-art sequencing technologies with subcellular proteomics, high-content screening, advanced biochemistry, and single molecule RNA imaging. In doing so, we will dissect the molecular signals and regulatory factors guiding this previously overlooked RNA decay pathway. Furthermore, we will determine the biological consequences of pathway dysfunction on transcriptome integrity, cellular fitness, and the shaping of cellular identity. Together, this work will provide crucial insights into the mechanisms governing RNA homeostasis during cellular stress. The findings will challenge our current view of autophagy and uncover fundamental new understanding of gene expression regulation in health and disease, with broad implications across the biological sciences.


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