RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pay-roll accounting and settlement system' (PASS) under Fourth Framework.

assistant: **Objectives**

PASS (Pay-roll Accounting and Settlement System) is a new business project. Its business purpose is to develop a modular, platform independent, integrated networked software system satisfying functional requirements of EU standards in public accountancy and applicable for the Hungarian as well as for the international market. The system will provide direct service among Employers, Employees and Banks. The objective of the PIE is to improve the control of the development process (QA Unit, structured system analysis, improved testing process, efficient project planning, ISO 9001 documentation). Increasing the maturity level to 3 (at least 2.5). In certain attributes level 4. Compliance with ISO 9001 requirements.THE EXPERIMENTThe experiment consists in substantial improvements in: Organisation (quality management, project management, training)Methodology (quality manual, documented process, standardised testing methods, measurement)Technology (Object Oriented Programming Module Library, configuration and change management, graphical planning tools)EXPECTED IMPACT AND EXPERIENCEMemoLuX Ltd is steadily growing and is managing larger and larger projects. While introducing best practices the company will effectively manage a higher number of projects in the future by reusing lessons learned. MemoLuX will benefit from having better control of the software development process, from the achievement of a quantitative view of the production process, from the higher credibility among Hungarian and EU customers through improved Bootstrap maturity profile and an increased level of compliance with ISO 9001. ISCN runs a dissemination business line including an annual conference about process improvement, a WWW process improvement newsbox, as well as training's (a European training init
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Lymphoid Organoids to Study Immune Synapse in Lymphoma Therapies' (LOISE).

assistant: **Concept**

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL) in  Europe and worldwide with more than 463/100 000/year. Activated B cell (ABC)-DLBCL represents the more aggressive and chemo-resistant subtype to the frontline therapy Rituximab (R)-CHOP (doxorubicin, vincristine, prednisone, mechlorethamine) with 40% of patients experiencing no response or relapse. Therefore, new treatments are needed to improve the clinical outcome of ABC-DLBCLs. A newly defined characteristic feature of the ABC-DLBCL subtype is the concurrent constitutive activation of B cell receptor (BCR) and Toll-like receptor (TLR) pathways that result in the upregulation of the NF-ĸB through cooperative signaling. In ABC-DLBCLs  the NF-ĸB signal is mediated from the downstream regulator Mucosa-associated lymphoid tissue lymphoma translocation protein 1(MALT1) paracaspase that is upregulated in 70% of these tumors.. For this reason, MALT1 paracaspase has become an attractive therapeutic target and MALT1 inhibitors have been developed.. However, previous studies indicate that approximately 63% of patients respond to BCR pathway inhibitors, and therefore understanding factors such as the intricate survival signals imparted by the lymph node tumor microenvironment (LymphTME) in ABC-DLBCL is critical for clinical translation of MALT1 inhibitors. Two key elements of the LymphTME are the infiltration of T helper cell (Th) and the activation of ECM mediated pathways. The Aim of LOISE project is to establish an ex vivo organoids that will mimic the T immunological synapse and ECM features with the purpose to elucidate their role on ABC-DLBCL survival and signaling response to BCR pathway inhibitors. These organoids will be used to designed a combinatorial targeted therapy for A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'In vitro and In-cell characterization of Quadruplex-duplex hybrids: conformation, folding, and recognition by drug-like ligand molecule' (QDHassay).

assistant: **Concept**

Nucleic acids are intrinsically polymorphic. Apart from the Watson-crick duplex, guanine-rich sequences can form G-quadruplex  (G4) structures, which have become attractive targets for small molecule ligands. It is now proven that G-quadruplexes can form in cells. Today most biophysical and structural/ligand binding studies are carried out in dilute aqueous solutions and the presence of artificial crowding agents/cosolvents. Still, recent works suggest that the folding of G4s may differ in the cellular milieu context due to the agents' limitations. Thus there is an immense need for in-cell-based structural biology approaches. In the proposal, I aim to address critical milestones leading to the bioactive conformation inside the cell and the development of effective/specific G4 targeting drugs using an essential sub-class of G4 structures as a paradigm, namely quadruplex−duplex hybrids (QDH-hereafter). We will focus on low- and high-resolution spectroscopic approaches and mass spectrometry-based ligand screening assays characterizing ligand-QDH interaction. On the methodological part, we will develop in-cell NMR  in ""native"" conditions (starting from unfolded conformation: denovo folding) and propose a ligand screening assay inside the cellular system. Our project will contribute to unveil fundamental principles of nucleic acid folding. It will also foster collaboration between two European institutes specialized in complementary biophysical and structural approaches to study biomolecular folding. In a nutshell, the Maria Skłodowska Curie fellowship will flourish my scientific excellence and the resilience needed for my original ideas to become a reality and communication and public engagement skills across cultures and disciplines.""


**Keywords:** NMR, In-cell NMR,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Construction and production of cemented carbide gear manufacturing tools for high speed cutting processes'.

assistant: **Objectives**

Objectives and content Despite important technological and economic advantages, the use of dry high-speed machining with coated cemented carbide tools has not yet found acceptance in the gearmaking sector. The main reasons are to be found in high tool costs and as yet unsatisfactory process reliability. The objectives of the planned project are therefore to develop a technology for the efficient production of cemented carbide hobs and to create the necessary conditions for widespread use of dry high-speed hobbing in European industry, through the development of effective cemented carbide tools specially suited for coolant-free cutting. In the field of cemented carbide hob manufacture, the development of a grinding test bed meeting the requirements for grinding and profiling cemented carbide hobs with dressable diamond grinding wheels under laboratory conditions will be of vital importance. Significant innovations are the dresser unit integrated in the grinding test bed, with path-controlled dressing of diamond grinding wheels, using diamond dressing rolls, and the development of corresponding, efficient, dressable diamond grinding wheels. The overall development of an efficient process for the manufacture of cemented carbide hobs will be completed by new cooling lubricants and optimisation of the process parameters both for grinding and dressing. Another key area of the project is the adaptation of the gear cutting tool properties to the special requirements of dry high-speed hobbing. New cemented carbide substrates and hard thin films will be developed, together with the coating technology needed to deposit the films. In this context, the development of effective de-coating and re-coating methods for cemented carbide hobs is of great economic importance. Development ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dynamics of Homeomorphisms, Noninvertible Maps and Flows with Respect to Minimality' in the context of a Sixth Framework call.

assistant: **Objectives**

The project is in the area of Topological Dynamics, one of the main branches of the Theory of Dynamical Systems. We study minimality in discrete-time dynamical systems given by noninvertible continuous maps or homeomorphisms, as well as in continuous-time dynamical systems given by continuous flows.Our attention will be focused on, but not reduced to, the following problems:1. Existence of minimal maps and/or homeomorphisms on manifolds and more general spaces;2. Classification of minimal sets on manifolds and more general spaces;3. Denjoy minimal sets;4. Cantor minimal systems and their embeddings into manifolds;5. Existence of minimal flows - the Gottschalk Conjecture and related problems.In the research we will use various techniques from different areas of mathematics - besides the theory of dynamical systems, mostly from algebraic topology, general topology, mathematical analysis, etc. We want to reach the results by bringing together the expertise of the applicant with that of the host institute.We can summarize the relevance of the project to the objectives of EIF in the following points:1. reinforcing professional maturity of the applicant by adding scientific competencies;2. diversifying the applicant's expertise;3. involving research teams from less-favoured regions;4. producing and supporting long-term synergies;5. building a free EU research area by integrating the new member states.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Photocaged Kinase Inhibitors as Molecular Tools for Investigating Neurodegenerative Diseases'.

assistant: **Objectives**

Protein kinases play a critical role in a number of cellular processes, including cell proliferation, differentiation and apoptosis. Recently, the aberrant regulation of lymphocyte-specific protein tyrosine kinases (LCK) has been associated with the over activation of microglia cells (important immune effector cells that reside in the central nervous system, CNS) and in turn, the development of Alzheimer’s disease (AD). Unfortunately, the detail of LCK's dynamic function and the importance of quantitative, spatial and time-dependent parameters regarding microglia activation is poorly understood. As such, the ability to manipulate LCK activity using light would result in temporal control of enzymatic activity, thus serving as a valuable approach to probe the function of LCK in microglia cells and in turn, further our understanding of AD and related neurodegenerative disorders. While such studies cannot be performed using conventional LCK inhibitors, this project aims to control the enzymatic activity of LCK by the development of a stimuli-responsive release-and-report system, through the introduction of a photolabile 'caging' moiety onto a fluorescent kinase inhibitor. The caging group will also consist of an appropriate ‘quencher’, quenching the innate fluorescence properties of the inhibitor through energy transfer (FRET). Exposure to light (> 320 nm) will result in decaging of the prodrug to give the active form, while simultaneously switching ‘on’ the fluorescence — reporting back to the user that the compound has been activated. To demonstrate the potential of the release-and-report kinase inhibitor as a tool to probe LCK function in microglia cells, confocal microscopy will be employed to visualise the site of microglia activation and the time frame during CNS deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Training courses for operators of the RODOS system' (1998-2002).

assistant: **Innovation**

The development and the perform-ace of the proposed training course for RODOS operators is one important step forward in the process of introducing the RODOS system within Europe, in particular the EU and the accession countries, and in ensuring its operation by qualified personnel. Only with a detailed knowledge of the systems functions, its capabilities and the results achievable, the RODOS system will become a valuable support tool within the national emergency arrangements. The complete set of the training material together with the RODOS documentation will be made available to the countries operating RODOS now or in future. Guidelines for customising the training course and material will help perform national courses; in this way, money, time and effort will be saved in establishing national training courses for the continuous education of RODOS operators.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Unifying High-speed Interconnects'.

assistant: **Innovation**

The proposed work is in the area of building general-purpose computing and storage infrastructure for the future datacentre that support all IT activities. Today, such datacentres include various types of servers that support compute, storage I/O, client network I/O, and high-speed LAN applications.The requirements of such, modern datacentres to support a variety of IT services (mail, dbases, storage, backup, compute intensive applications, online services, etc.) lead to multi-tier architectures that require connectivity among different levels. One of the main problems of using multiple tiers in such architectures is the specialization of each tier to a specific type of functions or applications.For instance, a cluster used for computing cannot be used to service storage requests as well. This leads to an imbalance of using the available resources. Future datacentres can greatly benefit from symmetric architectures that allow the shifting of resources between tasks.This is made possible today by the fact that most computing resources within the datacentre are very similar, in most cases PCs or workstations in various forms, such as blade servers. The main inhibitor in moving to such architectures is the different interconnects that are used today for each logical subsystem in a datacentre.Moreover, the use of multiple, in some sense customized protocols and interconnects leads to high management complexity and cost, to difficulty in upgrading to new generations of each technology, and, in some cases, to proprietary solutions due to incomplete standardization. These are all significant issues for the evolution of datacentres and their ability to effectively support increasing needs.The goal of this work is to tackle this problem and develop the technology required to uni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ZnAnosT za vsE (Research for all)' (ZATE) under Horizon 2020.

assistant: **Objectives**

The key ZATE message is that everyone can become a researcher? and main project aims are to bring researchers to the general public, to inspire youngster to embark on science careers and increase awareness of: researchers' profession, the possibility of various careers in academic and non-academic institutions, understanding EU, the path to embark and develop research careers, researchers' important role in society and highly important impact of their work on our daily life.  Inclusiveness is the key, not only when we speak about society, researchers (in all aspects) but also the young with less opportunity to get in touch with science (bus transport to ERN event). The intensive (off/online) awareness campaign (AC) will include national cooperation of selected ERN consortiums, various pre-events, national reward competition, Train the trainers and multipliers program. On traditional ERN main event renewed programs in a festive and fun atmosphere. Pre-events and events activities aim at offering the public at large an opportunity to get engaged in science through fascinating experiments, demonstrations, observations, to socialize and have fun with researchers in a relaxed atmosphere. They include various interactive activities of a wide range of science fields. ZATE activities will be implemented in Maribor, Krško, Koper, Izola and Nova Gorica. Trained researchers will interactively present research and innovation results. EU dimension will be visible, presented also by representatives of NCPs (MSCA, ERC), Europe Direct, SBRA Brussels. Traditional cooperation of the primary and secondary schools' winning teams of research and innovative projects in the frame of Youth for Maribor Progress (financed by Maribor municipality) is included again, as a way through which young e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards a postgrowth economics: A viable postgrowth economy without increasing inequality' (PostGro).

assistant: **Innovation**

Economic growth seems unlikely to continue at current rates, if at all. But we currently do not have a plan of how to manage a postgrowth economy. This represents a major impediment to formulating policies for how the EU may best pursue its objectives for development, environmental protection, and the elimination of poverty in a future postgrowth economy. There is debate over whether our current economic system based on interest-bearing debt can be made viable postgrowth, and evidence that even slowing growth leads to increasing inequality. Here, I propose research to integrate existing theoretical research into postgrowth viability with research into measures to prevent inequality from increasing. Since no industrial economy has yet experienced prolonged periods of very slow or negative growth, I will test the predictions against historical case studies. The project will achieve four objectives: to identify the parameters in which a postgrowth economy is viable; to identify the parameters in which continually increasing inequality is also avoided; to test these parameters against historical case studies; and to draw on these results to evaluate policies for producing a postgrowth economy that is both viable and avoids inexorably increasing inequality.  The fellowship will allow me to broaden and deepen my knowledge of ecological economic approaches to postgrowth whilst bringing my knowledge of property economics, comparative institutions, and historical postgrowth to my hosts at ICTA. We will disseminate the results to academics and policy makers, with the historical aspect making quite technical debates much more accessible for communication to a wider public.The fellowship will place me, and ICTA, at the forefront of the emerging field of theoretical and historical p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Wide Angle and Resolution Metrology' to be submitted under Horizon Europe.

assistant: **Abstract**

WOOPTIX will upgrade to a 300mm field of view (FoV) metrology system a ready-to-market 50mm field of view Wooptix´s tool, based on a disruptive technology that measures the phase component of a beam of light (wavefront sensor) with a naked sensor, reaching a resolution orders of        magnitude higher than other wavefront sensors. This technology has been patented by the company. The scalability of the solution will present an outstanding business opportunity for WOOPTIX leading the company to achieve an amazing turnover rise. Our semiconductor metrology system is capable        of measuring the full 300mm silicon wafer geometry with a lateral resolution of 3.2µm and a height resolution of 0.3nm acquired in a single image snapshot in 100ms while capturing 15 million data points. The system works by using a standard digital image sensor to acquire the intensity of        the reflected, non-coherent light from the silicon surface at two sperate locations along the optical path.


**Keywords:** wavefront phase,Wafer Geometry,silicon device manufacturing,semiconductor equipment