RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'To develop a new targeted therapy for the treatment of naive and PARP inhibitor-resistant BRCA1/2-mutated tumors' in the context of a Horizon Europe call.

assistant: **Objectives**

Breast and ovarian carcinomas are aggressive tumors with few treatment options and high recurrence rates. About half of these tumors shows defects in homologous recombination (HR) repair. Defect in HR (HRD) causes genomic instability and dependence on poly (ADP-ribose) polymerase (PARP)-mediated DNA repair. As a result, PARP inhibitors (PARPi) are now widely used for the treatment of these tumors. However, resistance to PARPi is emerging as the major obstacle to clinical effectiveness. Consequently, many patients run out of treatment options and succumb to the disease. This prompts the development of novel therapeutics.Beyond its well-known functions in regulating metabolic processes, we discovered that enzyme X maintains genomic stability in HRD cells. Enzyme X inhibition kills HRD cells without affecting HR-proficient cell survival pointing to a synthetic lethal interaction between enzyme X and HR genes. Moreover, we showed that enzyme X functions independently of PARP in the survival of HRD cells. As a result, enzyme X inhibition kills naive and PARPi-resistant HRD cells. Thus, targeting this enzyme has the potential to provide a new cure for HRD tumors.No inhibitors nor patents on enzyme X exist. HRD tumors being a major economic burden worldwide, developing enzyme X inhibitors has high innovation and financial reward potentials. By screening chemical libraries, we identified a top hit inhibitor of enzyme X. Our TargetBRCA project aims at improving potency and specificity of our molecule inhibitor and provides a proof-of-concept on its use as a cure for HRD tumors. TargetBRCA relies on complementary teams of crystallographers, chemists and specialists of HRD tumor biology and associates structure-aided drug design with the use of preclinical in vivo models. Our ulti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SAFE EFFICIENT BATTERY SYSTEM BASED ON ADVANCED CELL TECHNOLOGY' in the context of a Horizon Europe call.

assistant: **Objectives**

BATSS project will focus on the development of a novel battery system concept which exhibits improved high-performance and safety, as a way to unlock the market uptake of next-generation battery system to a broad range of transport applications. The project will develop a specific Safe-by-Design (SbD) approach to guide the whole R&D process, aiming at identifying and mitigating (even eliminating) safety risks across the life cycle of the battery, while also allowing to counteract possible performance and cost trade-offs linked to the implementation of safety barriers in the battery system. The Consortium will develop a new cell-to-pack modular concept targeting at an outstanding safety and electro-thermal performance, mainly for off-road devices (construction site vehicles) and waterborne transport (maritime passenger vessels). BATSS consortium will develop, up to TRL5, the different thermal, electric and mechanical innovations to meet (and improve) the industry use cases performance and safety requirements, guided by the SbD approach and supported by cutting edge modelling and simulation tools for the battery system design and predictive maintenance functionalities of the Battery Management System (BMS). Last, but not least, the end of life (EoL) step will be under the scope through (i) the modular concept enabling easier assembly-disassembly of used battery systems, (ii) the data-supported automated disassembly techniques, and (iii) the exploration of battery system second life in a semi-stationary product.


**Keywords:** Safety, Battery, Modular, Fire, Thermal runaway, Model, HIL, Ultrasonic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Women’s imprisonment, social control and the carceral state – an interdisciplinary study of the experiences of detention' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Women’s imprisonment, social control and the carceral state – an interdisciplinary study of the experiences of detention Prison research in Germany is largely of a quantitative nature and overwhelmingly based on male prisoners who make up the vast majority of the prison estate. The fact that women are far fewer in number can pose  a variety of challenges for prison administrations, often resulting in less favourable treatment as compared to imprisoned men. WISCA responds to the Council of Europe’s call for more research and gender-sensitive monitoring which is attuned to the potential compounding of problems women face in prison. Prison research is mainly based on generalisations from mainstream male prisoners (Howe 1994; Loeber et al 2007) and women have remained largely absent from studies into key penological issues such as legitimacy and order (Bosworth 1996; Liebling 2009). Female prisoners are particularly interesting, however, precisely because many reform agendas are trialled on this relatively small and seemingly more manageable group (Kubiak et al. 2017). While attention has been directed towards the Nordic countries in search for penal reform ideas (Pratt & Eriksson 2015), central European countries have been overlooked despite low imprisonment rates; and little is known about prisoners’ experiences in Germany due to a lack of qualitative research. Further, carceral geography as a newly emerging discipline has so far seen no German data, so this project will provide an expansion of carceral geography and qualitative criminology into the German-speaking interdisciplinary field. Using mainly qualitative research methods with some quantitative elements, WISCA will address these gaps in scholarship by focussing on the experiences of female prisoners in order to e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Functional redundancy of bacterial communities in the laboratory and in the wild' in the context of a Seventh Framework call.

assistant: **Objectives**

Understanding how species mediate ecosystem processes, such as energy and nutrient fluxes, is among the foremost challenges in ecology. Bacterial communities are pivotal for the functioning of the world’s ecosystems. Although there have been great advances in describing the biodiversity of bacteria, little effort has been directed at understanding how differences in bacterial communities translate into differences in ecosystem functioning. The proposed research will develop a comprehensive framework to determine how bacterial species affect functioning while in complex mixtures of species. Once this baseline is obtained, it is possible to ask detailed questions about the ‘functional ecology’ of bacterial communities. Foremost among these is whether ecological processes (species sorting) are more important than evolutionary processes (adaptation) in establishing species roles in ecosystems. The research has implications for the fundamental understanding how ecological communities operate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The control of embryo implantation: studies of gene expression, protein profiles / functions at the utero embryonic level: cellular and molecular developmental events at the feto maternal interface', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

EMBIC virtual European laboratory on major mechanisms of implantation will study thoroughly the main cellular - cytokine networks/ key pathways promoting the de novo development of the decidua basalis and the mature placenta. Present fragmentation of experimental capacity and disparate approaches result in lack of a comprehensive skills base, and of access to specialised approaches/ technological platforms such as strict animal experimentation, genomics and proteomics facilities or multicentric clinical evaluation. Which need coordinated approach. We will thus: 1. Assemble critical talents and approaches, to Integrate EMBIC laboratories via the joint programme of activities: 1.1. Early embryo signalling to ultimately allow selection of only those embryos which will effectively implant; 1.2. Key events in tissue remodelling: 1.3. Homing/ proper activation of Natural Killer (NK) cells 1.4. Role of MHC class I gene products and their recognition by NK cells 1.5. Control of the inflammation complement related pathways 1.6. Cytokine/ chemokines/ profiling 1.7. Invasion and early post implantation events, Matrix Metallo Protease based proteolysis/ adhesion molecule functions. 2. Constitute a European cohort of infertile women and RT generated DNA, sera and micro-biopsy tissue samples banks. 3. Establish guidelines for management of infertile women combined with diagnosis procedures and ultimately recombinant technologies therapies for selected pathologies. 4. Open the network for education and cooperative experimentation. EMBIC will contribute and benefit from the creation of integrated platforms based on animal models, genomic and proteomic facilities, protein intra-net database set-up, integrated clinical set-up, and will spread excellence by facilitating the exchange of sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Visual identity verification auditor' to be submitted under Fourth Framework.

assistant: **Abstract**

The main objective of the VIVA project (Visual Identity Verification Auditor) is to investigate and demonstrate a professional broadcast surveillance system.Broadcast material will be pre-encoded with an invisible unique watermark identifier. By automatically monitoring television broadcasts and registering which assets have been pre-encoded, a mechanism for IPR protection will be provided. In this project algorithms for digital watermark embedding and extraction will be developed and implemented in hardware and embedded software using existing components. Field trials will demonstrate the feasibility of the system. The applications of such a system include copyright protection and proof of ownership, verification of commercial transmissions, assessment of sponsorship effectiveness, protection against illegal transmission, statistical data collection and analysis of broadcast content. The watermarking technology to be developed in this project by Philips Research will be optimized for the high picture quality needed in the broadcast environment and will avoid the introduction of visible artifacts into the picture. At the same time, the watermark should survive signal processing operations which routinely occur in broadcasting systems, such as digital to analogue conversion, editing, compression and standards conversion. WTN and Philips BTS intend to exploit the results of the project by setting-up a global automated monitoring system for copyright protection surveillance using detection of the embedded watermark as a unique identifier.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Circular Economy Business Models for innovative hybrid and electric mobility through advanced reuse and remanufacturing technologies and services' to be submitted under Horizon 2020.

assistant: **Abstract**

Electric and Hybrid Electric Vehicles (E&HEVs) will be an opportunity to drastically innovate mobility products and services in the direction of sustainability and of higher accessibility for customers. If coupled with innovative services offered by car manufacturers in a network of well coordinated partners supporting extensive and efficient End-Of-Life operations, the advent of E&HEVs could revolution the current mobility consumption uses of people and preserve the environmental much more than the only substitution of traditional cars with E&HEVs could do. In particular, non-ownership based models of E&HEVs with additional added-value services (leasing or renting contracts with periodic upgrade through remanufacturing, pay per use, etc.), would give OEMs the possibility to establish long-term customers relationships on one hand, and of setting-up innovative supply chains that performs systematic remanufacturing and reuse of E&HEVs parts in order to maximize the residual value of components and materials on the other. Remanufacturing, reuse and recycling would become the strategies upon which car manufacturers would base future competitiveness, leveraging on the benefits of costs saving and, at the same time, guaranteeing environmental benefits and superior performances to customers. However, there are substantial barriers to implement these new business models. The main one is developing adequate capabilities to remanufacture and reuse E&HEVs’ components and materials in order to provide customers with added value. This is significantly difficult especially from the technological point of view, since E&HEVs determine  a fundamental transformation in vehicles design, featuring a substantial evolution in the critical components and materials.The CarE-Service project wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Printing personalised medicines on demand' to be submitted under Horizon 2020.

assistant: **Abstract**

Methods of pharmaceutical manufacturing are likely to change dramatically over the coming years. Driven by the knowledge and technology that is already available in other sectors, the processing of drugs into dosage units can be transformed into a “pharmacy-on-demand” process that allows individual dosing, based on criteria relevant for the effective use of the drug in an individual patient. One approach to achieve “pharmacy-on-demand” is the use of inkjet printing technology to deliver an exact dose of drugs on porous substrates. This proof-of-concept project is based on knowledge we acquired during my ERC AdG project on processes of printing on paper using inkjet printing. We will demonstrate the viability of ""printing"" highly accurate amounts of a solution containing levothyroxine, prescribed for hypothyroidism, onto a porous tablet. Modelling tools will be combined with cutting-edge characterization technologies to push the understanding of printed drug-containing inklike solutions in porous dosage unit matrices. This project will transfer pharmaceutical formulation and product design of individual dosage forms with the use of inkjet printing technique to the pharmaceutical community. They can work on clinical approval tests of the developed oral dosage forms and move these products toward clinical use. The patients will benefit directly from development of this production technique, because a much more effective and targeted medication can be provided. The next step will be the development of the inkjet printing technique for other personalized medicines such as pain killers for children, hormones, biomacromolecules, psychoactive and anticancer drugs. Individually-dosed medicines will allow for substantial decrease of drug waste and thus overall reduction of medi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hyper-targeting CAR NK cells from induced pluripotent stem cells for novel off-the-shelf anti-tumor therapies' (HyperTargIPS-NK), addressing dissemination and exploitation.

assistant: **Impact**

The HyperTargIPS-NK project aims to combine novel technologies from three research laboratories and a stem cell company to develop a revolutionary therapeutic modality for patients with devastating refractory malignancies. The treatment we propose is based on allogenic transplantation of induced pluripotent stem (iPS) cell-derived natural killer (NK) cells, genetically modified to a hyperactive state to ensure high potency NK cell targeting and destruction of tumor cells. CAR NK-based cancer treatment is an extremely promising new therapeutic avenue. However, the full potential of CAR NK therapies will only be achieved when an off-the-shelf product is rapidly accessible to patients in need. IPS with its unlimited expansion potential is the ideal cell source for NK-based products, however, improved efficiencies of NK cell production, suitably activated status, and resistance to immune suppression would need to be achieved. We have several breakthrough technologies to address these issues with 1) a novel iPS cell differentiation system based on our newly identified metabolic regulators that can be easily scaled to generate billions of functional NK cells, 2) identified and validated several novel and state-of-the-art CAR, non-CAR and TRUCK based regulators of NK activation to elicit the hyper activated NK cell state and prolonging NK survival, and 3) improved NK response to tumors via tumor microenvironment remodeling.  We will target the NK cells towards three life-threatening cancers for which novel treatment options are urgently needed as they are considered among the most lethal cancers; i.e. Pancreatic cancer, Glioblastoma, and Acute Myeloid leukemia (AML). Our iPS culture system, NK activation systems, and gene editing systems, have already been designed towards GMP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Disaster Resilience Knowledge Network promoting innovation, technology uptake and multi-stakeholder cooperation' (DIREKTION).

assistant: **Innovation**

The number and severity of disasters are increasing in Europe, due to climate change, ageing of industrial facilities and infrastructures, geo-political instability, poor knowledge management for critical activities and the vulnerability of the population exposed (density, age, migration…). To face these challenges, firefighters, rescuers, emergency medical responders and civil protection staff, have to implement effective and affordable solutions to support their operations. The DIREKTION project will establish and implement mechanisms and procedures to enhance knowledge sharing by directing the development of innovative technologies answering the needs of practitioners and policymakers. The steering role of international organisations (CTIF, FEU) and end-users will guarantee useful and practical results.The project starts with the deployment of tools assessing the relevance and interoperability of innovative technologies developed by EU Horizon projects. A structured analysis of needs and gaps and the screening of potential solutions will then be undertaken. The procedures will use the outcomes of projects like FIRE-IN, DRIVER+ / CMINE, MEDEA, the pilot for the Network of European Hubs for Civil Protection and Crisis Management and will follow the taxonomy of the EU security market study to ensure a structured use of results. Based on the capability-driven evaluations and a detailed analysis of the opportunities and constraints for the uptake of innovative solutions, DIREKTION will establish priorities for future research programming and capacity building. Moreover, the project will further establish networking and dissemination opportunities of interest for the DRS community in close collaboration with industry, SMEs & start-ups, research organizations and practition