RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Secretion of inflammatory mediators from eosinophils and their tissue residing cell-free granules: mechanisms and implications in inflammation' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Eosinophils, both as end-stage effector cells and as Th2-immunomodulators, have the capacity to secrete varied inflammatory mediators, such as, cytokines and enzymes that are stored in their cytoplasmic secretory granules. Among them are the cationic proteins: major basic protein, eosinophil peroxidase, and the eosinophil RNases.  In the last decade several studies, both in vitro and in vivo, have revealed a pivotal role for eosinophils and their granule content in immunomodulation, host defence and in pathology of eosinophil-associated diseases, such as allergy and asthma. Eosinophil secretion of granules content (e.g. degranulation) and the deposit of its cationic proteins are associated with a range of inflammatory disorders. Degranulation typically by means of piecemeal degranulation, is a controlled and selective process. In addition, at sites of inflammation, cytolysed eosinophils release cell-free granules, that reside in inflamed tissue.Recently, studies by me and my colleagues have revealed that beside secretion from intact cells, cell-free granules released from human and mouse eosinophils during lysis have the ability to secrete their content in response to cytokine stimulation in a cell free context. However, the mechanisms of these two methods of secretion and the key factors that participate in the degranulation process in intact eosinophils and especially in cell-free granules are poorly understood.The current proposal aims to explore the physiological functions of the newly discovered mode of secretion from eosinophil-derived cell free granules in allergic airway inflammation and the mechanisms by which integrins cooperate with elements of the cytoskeleton machinery in regulating chemokine-mediated degranulation in eosinophils. These studies will enhance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The impact of climate and other hydrological events on european water supply planning and management.'.

assistant: **Innovation**

The aim of the project is to produce a methodology to support water undertakings in assessing the impact of climate change and other hydrological events on the management and development of water resources and supply networks. The project will consider methods for advising the water supply managers and planners on making better use of the existing sources in daily and weekly operation from the point of view of minimising the risk of failure to meet demand, preventing over-exploitation of sources and using the sources most cost-effectively. It will also look at longer-term issues, principally the effect of changes in climate on source operating strategies and how formal models of source hydrology and of the supply network can be used to plan the evolution of the water system to meet changing patterns of demand, climate and other environmental influences. The aim of this is to reduce the development of new sources (which can be expensive and environmentally intrusive) either by operating the existing sources in a more efficient way so as to increase their safe yield, or by increasing the capacity of the supply network through capital development.The methodology will be supported by a software prototype that integrates models of the supply network and of the hydrological behaviour of sources. The first step in the project will be to assess the state of the art of source modelling, both by reviewing the literature and by examining the models and operating rules in current use in the water industry. A task analysis of the European Water Industry will be undertaken to determine the critical needs of the industry in relation to resource allocation and planning, to focus the methodology on the priority requirements. The methodology will be developed in a practical, iterative wa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A new media platform to accelerate public awareness on IST' (IST-TV) targeting Fifth Framework.

assistant: **Abstract**

IST-TV aims to disseminate the results of the IST Programme to the general public in 31 European countries. This will be done through a) the identification of the IST key results; b) the development of a series of original high-quality audiovisual productions based on the findings of the IST Programme; c) the exploitation of the existing technological new media potential by setting-up an integrated multi -access new media platform acting as the principal access and service point for the project's target audience; d) the performance of an intensive dissemination and communication campaign towards the media of 31 European countries; e) the broadcasting of project's audiovisuals on several TV channels Europe-wide. The project expects to communicate in a robust and coherent way the key results of the IST Programme to all the European media communities and to several tens of millions people Europe-wide.OBJECTIVESThe main objectives of IST-TV are:a) to fill the existing communication gap between the technical results of the IST Programme and the understanding skills of the general public;b) to contribute to the development of public awareness on IST issues in 31 European countries;c) to exploit new media convergence technologies to pilot an innovative audio-visual production and distribution concept for the European research;d) to accelerate the creation of IST issues in the Newly Accessing countries.DESCRIPTION OF WORKThe IST-TV workplan is sub-divided into 6 workpackages, covering the following activities:- to monitor the work of the IST Programme and to retrieve the IST key results, i. e. a series of non-technical key statements reflecting the technical work undertaken by the IST Programme (WP1);- to conceive and develop a series of 36 original high-quality TV audio-visual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Fragments of the Forest: Hot Zones, Disease Ecologies, and the Changing Landscape of Environment and Health in West Africa'.

assistant: **Objectives**

Why have certain regions, like West Africa, rich in biodiversity, also become identified as emerging disease hotspots in scientific and popular understanding? VIRHIST aims to discern the ecological, economic, political and social forces at play that have simultaneously turned certain regions into profitable sites of natural resource extraction, productive enclaves of biomedical research, and hot zones of pandemic threats.  At its core, the project seeks interrogate how Western economic interests tied to natural resource extraction in West Africa produced new understandings about the ecology of disease, while simultaneously creating new environments and species relationships--in the laboratory and on the plantation--that eliminated certain diseases, but also creating conditions of possibility for other pathogens to thrive. VIRHIST offers a groundbreaking approach, stimulating cross-fertilization and interaction across the fields of environmental history, medical history, and STS, to develop new perspectives on the history of environment and health.  Through a focus on three bloodborne diseasesyellow fever, hepatitis B, and Ebola at three distinct moments in West African history, VIRHIST advances the following research objectives: 1) Identify and substantiate the intended and unintended changes in disease ecologies produced through industrial plantations and biomedical interventions; 2) Interrogate the shifting ethics and economics driving emerging infectious disease research in West Africa in an age where biosecurity, surveillance, and pandemic anxieties mobilize significant resources and attention; and 3) Investigate the changing ethical, commercial, legal, and political standards that have shaped the collection and extraction of natural resourcesfrom rubber, to chimpan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biosynthesis regulation and function of trh-like peptides' under Fourth Framework.

assistant: **Concept**

Our objectives are (1) to complete our identification of the biosynthetic origin of two TRH-like peptides which we first identified in human seminal fluid (2) to extend our knowledge of their physiological roles and (3) to identify factors involved in the regulation of their activity. The actions of pGlu Glu Pro amide are consistent with a role in fertility and we propose to study these two peptides in, and their action on, infertile males. The two peptides also exhibit central activities, some in common with benzodiazepines, and we will study these at the molecular level. During our studies of TRH-like peptides in the thyroid gland, we found that marmoset and human thyroid contain high concentrations of authentic TRH, together with a TRH-like peptide, suggesting a functional role for the thyroidal TRH. We also find that the levels of TRH in rat thyroid reflect the thyroid status; we intend to investigate the mechanisms involved. We are also developing a reliable method for the determination of TRH and TRH-like peptides in the circulation which will have clinical application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ASMED: Multi-channel, low noise, low power, data acquisition chip for mobile medical applications' in the context of a Fifth Framework call.

assistant: **Objectives**

The objective of ASMED is to apply new ASIC design concepts to the development of a new generation of ASIC's for advanced medical devices. The key innovation is to achieve a standard ASIC which may be used for a range of bio-data signals, thereby replacing the discrete, single application dedicated and often hand selected components used in current bio-data measurement equipment, e.g. ECG (Electrocardiography), EEG (Electroencephalography) and EP's (Evoked Potentials).The ASIC will enable devices to be developed which are more compact, more reliable, more comfortable for the patient and able to be worn by the users or medical diagnostics data acquisition purposes in normal ambient conditions. It will also enable significantly lower production costs to be attained.Objectives:The key objective of this project is to specify and develop an ASIC Which will enable power consumption to be reduced by a factor 5-10 (to max. 10mW per channel) and thereby permit ambient devices to be developed foe at least 12 hours mobility, and to improve the signal to noise ratio by a factor 2 compared with current systems. These design goals will be achieved using the specific experience of the research performer in ASIC chip design using a predictive coding methodology specially optimised for medical applications.Work description:WP0 Project ManagementConsists of the technical and administrative management of the project including organisation of the mid and final review and preparation of the exploitation of results.Task 1.1. Requirements study ANS & Polysomnography;Task 1.2. Requirements study Neurology;Task 1.3. Requirements study Cardiology:- Identification of user needs;- Interviews with user;- Definition of target applications;- Definition of medical instrument functions;Task 1.4. Prelim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Financing Ambitious Local Climate Objectives'.

assistant: **Objectives**

Implementing ambitious local climate action plans is paramount in the fight against climate change. Moreover, the sheer aggregated investment volume contained in these plans holds the promise of a powerful longlasting economic recovery. Unfortunately, the lack of a comprehensive funding solution undermines the realisation of these plans.  FALCO addresses this problem by developing a financing solution for ambitious local climate plans of over 180 Flemish signatories to the Covenant of Mayors (“FLC Solution”). This solution builds on the results of several previous projects, integrates state of the art knowledge on sustainable energy financing, and was tested at the conceptual level. Unlike other solutions, the FLC solution 1) looks at the climate action plans as a whole (potential for piggybacking) instead of adopting a project-per-project view (risk of cherry picking); 2) focuses on lifting financial and non-financial investment barriers; and 3) uses private capital instead of public budgets for its financing operations. In addition, FALCO will develop accompanying (policy) measures that will induce demand for investments. FALCO is designed as a scalable pilot that allows real-life testing of the FLC solution.  FALCO will:• Develop the theoretical FLC solution into a fully operational financial solution (WP2);• Develop a project portfolio (ca. 50 mio €) w.r.t. energy efficiency in SMEs and energy renovation of public and private buildings (WP3);• Have an independent party due diligence validate the proposed financial solution and project portfolio (WP4);• Contract investments for at ca. 17.6 mio € resulting in an estimated 27.7 GWh primary energy savings and the creation of 250 sustainable jobs (WP5);• Monitor the investments and document lessons learnt (WP6);• Dissemi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mitochondrial Cannabinoid Receptors in the Brain' (MiCaBra) targeting Horizon 2020.

assistant: **Abstract**

Brain activity critically depends on the high energetic support provided by mitochondria, the cell organelles transformingenergy sources into molecularly usable ATP. The pathological effects of chronic mitochondrial dysfunctions in the brain areunder scrutiny, but the impact of physiological modulation of mitochondrial activity on ongoing brain functions is almostunknown. Cannabinoid type-1 receptors (CB1) are amongst the G Protein-Coupled receptors (GPCR) expressed at highestlevels in the brain, and they are key regulators of behaviour. We recently showed that CB1 receptors are present at brainmitochondrial membranes (mtCB1), where they regulate bioenergetic processes, thereby mediating amnesic effects ofcannabinoids. Thus, the physiological roles of the brain endocannabinoid system formed by CB1 receptors and endogenousligands, and the pharmacological effects of cannabinoid drugs (e.g. the psychotropic compound of the plant cannabis sativa,Δ9-tetrahydrocannabinol) partially rely on the regulation of brain mitochondrial activity. Using a bottom-up approach atmicro-, meso- and macro-scale levels, MiCaBra will reveal cell biological features, signalling properties and behaviouralimpact of mtCB1 receptors in the brain. First, we will address the cell biology of mtCB1 receptors, determining the structuraland molecular requirements for their mitochondrial trafficking. To define how this GPCR modulate mitochondrial activity andwhat are the functional consequences of these effects, we will study downstream intra-mitochondrial signalling of mtCB1receptors and the eventual impact on cellular processes controlled by the organelle. Finally, we will tackle the role of mtCB1receptors in the (endo)cannabinoid control of brain circuits and behaviour. Thus, MiCaBra has the ambitious a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Short linear interaction motifs as specificity determinants in the ubiquitin system – discovery, mechanisms and therapeutic opportunities'.

assistant: **Objectives**

A major challenge is the lack of therapeutic approaches for numerous human diseases, which poses a societal challenge. The ubiquitin system is a major promising source for novel therapeutic approaches but its potential has not been fully exploited due to limited insight and lack of researchers trained in understanding and identifying avenues to target the ubiquitin system. Ubiquitin ligases and deubiquitinating enzymes (DUBs) comprises enzymes that actively add or remove ubiquitin from proteins to regulate cell physiology. How these enzymes selectively recognize their substrates is largely unknown but an emerging theme is that a globular domain in the enzyme binds a short linear interaction motif (SLiM) in the substrate. SLiMs are short peptide motifs that constitute ideal entry points for understanding the ubiquitin system as they provide detailed insight into substrate selection and how this regulates the underlying biology. Further, SLiMs provide direct routes to therapeutic exploitation as they serve as peptide scaffolds for drug development and tools to highjack the ubiquitin system. The potential of SLiMs has not been capitalized upon because a method for efficient identification was missing, interactions between relevant partners were lacking and this has hampered training of young researchers. UBIMOTIF overcomes these barriers by exploiting novel technological advances to identify SLiMs and uniting outstanding complementary researchers and industrial partners with a common vision to provide outstanding training of early career scientist in SLiMs and the ubiquitin system. The UBIMOTIF topic provides ideal training of young researchers, as it requires a multidisciplinary and intersectorial approach providing training in multiple cutting-edge technologies. The impa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design of Electric LIght Vans for Environment-impact Reduction' under Seventh Framework.

assistant: **Concept**

CO2 emissions, noise emissions and other negative impacts caused by present urban delivery concepts and specifically by the delivery vehicles are unsustainable in present and future European urban life. Fully electric light delivery vehicles (LDV) not only offer zero local CO2 emissions and close-to-zero noise emissions.The change in propulsion technology from ICE to electric powertrains will lead to the integration of new components and systems, while others undergo changes or become obsolete. The possibility to integrate the electric motor into the wheel further increases the design freedom, especially if also suspension and regenerative braking can be integrated into it. This opens up new freedom in design and clears the way for new urban delivery vehicle concepts. DELIVER is to produce and physically showcase design research results that allow for full exploitation of this new freedom, while responding to changing future market demands.To achieve this key objective, the project generates, investigates and analyzes innovative design concepts for electric LDVs with motorized wheels. It delivers a range of advanced architectures which enable at least the same high level of intrinsic safety as known from current best in class conventional vehicles at minimal weight, maximised energy efficiency (40 % better than best-in-class ICE benchmark), optimized ergonomics & loading space at affordable costs as well as acceptable levels of comfort and driving performance.The program will culminate in a driving concept validation vehicle which will embody the optimum integration of systems as researched during the design and development stage.  The purpose of the vehicle is to validate the research results with the highest degree of reality possible within the budget. Some specific