RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GLYCANS AS MASTER TRIGGERS OF HEALTH TO INTESTINAL INFLAMMATION TRANSITION', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Chronic inflammation underlies several diseases. In Crohn´s disease (CD), there is mounting evidence of a preclinical phase characterized by immunological changes that precede symptoms. Here, we propose a thorough and innovative approach to better understand the health-to-chronic inflammation transition occurring in patients with CD that will be translated in improved disease prediction and prevention. We will address how changes in glycosylation of the gut mucosa act as a primary event that dysregulates not only local mechanisms (imposing maladapted host-microbiome interactions) but also systemic mechanisms (promoting anti-microbial antibodies production), involving the novel concept of glycan mimicry as an early trigger of the health to inflammation transition – GlycanTrigger. Capitalizing on our recent findings showing that changes in the expression of complex branched N-glycans at gut mucosa regulate Inflammatory Bowel Disease immunopathogenesis, we here hypothesize that changes in gut glycocalyx impose early perturbations in host-microbiome interactions, leading to the exposure of altered (glyco)neoantigens, both by pathogens and host epithelial cells which trigger the activation of innate immune response. Moreover, following our recent discovery that changes in glycosylation can be detected in serum years before CD diagnosis and are correlated with increased levels of pathogenic antimicrobial antibodies (ASCA), we will here pursue the hypothesis that changes in mucosa glycans constitute a major source for the development of anti-glycan antibodies (ASCA), associated with health-to-inflammation transition. The long-term GOAL of this proposal is to unlock, through an integrative approach, a new checkpoint that regulates the transition to chronic inflammation. Our pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Renewable energy systems for urban regeneration in cities of Europe'.

assistant: **Concept**

1. To install 1.8MWp of PV in 5 countries as part of significant urban regeneration programmes2. To demonstrate the application of PV as a re-roofing material in social housing planned refurbishment, thereby improving project viability by transferring roofing budgets to the PV budget3. To demonstrate the use of innovative energy trading mechanisms that are presented by a liberalised electricity market and the current political / environmental climate4. To demonstrate the use of innovative PV finance mechanisms by working with banks and finance companies to assess all the possibilities for innovative PV finance mechanisms5. To demonstrate the potential for cost reductions through competition and economies of scale6. To review, develop, demonstrate and disseminate best- practice social integration techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The unfolding protein response - quantitative analysis and post-transcriptional regulation of bip protein expression' (1994-1998).

assistant: **Concept**

Research objectives and content Perturbance of the endoplasmic reticulum (ER), either by the synthesis of mutant proteins or by the action of certain pharmacological reagents, lead to the accumulation of malfolded proteins in the organelle, which in turn elicits the unfolding protein response (UPR). This pathway has been described mainly as a transcriptional response that increases the levels of ER- resident chaperones such as BiP, therefore restoring ER function. Despite the progress in our understanding of the UPR, an accurate quantitative description of the pathway is lacking, and little attention has been payed to the possible involvement of post-transcriptional pathways that may regulate also the level of ER- chaperones. So, the objectives of our project are: (1) To analyze quantitatively the UPR For this purpose we will use HeLa cells stably transfected with the non-secreted immunology light chain under the control of a tetracyclin-dependent promoter. This could allow us to vary the expression of the light chain by 5 orders of magnitude. (2) To establish the importance of post-transcriptional pathways in the expression of ER-chaperones, specially BiP. We will use the same system as above but also expressing other protein constructs as stated in the RESEARCH PROJECT. Training content (objective, benefit and expected impact) The main objective is to obtain a detailed quantitative analysis of the UPR and to stablish the role of post-transcriptional pathways in the expression of ER-chaperones. This will have special relevance in three aspects: basic research, health care and biotechnology. Concerning the first, the UPR is a very important pathway controlling the level of ER-chaperones and therefore the level of secretory and membrane proteins in the cell, and is proba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'When Humans and Algorithms Co-Supervise Workers: Algorithmic Management Under Conventional Employment' in the context of a Horizon Europe call.

assistant: **Objectives**

In recent years, we have been witnessing a move to algorithmic management, in which supervisory tasks—instructing workers; appraising their performance; and determining their compensation—are being delegated to software applications. Current understanding of such effects is limited, however, as most research on algorithmic management focuses on gig-economy platforms in which traditional supervisory relationships are absent. The proposed research thus aims to explore: How does the introduction of algorithmic management in traditional organizations—in which algorithms operate alongside rather than instead of a human boss—shape human supervisory relationships and practices? To achieve this objective, I will undertake four subprojects, grounded in an empirical, in-depth qualitative approach. Subproject 1 will develop a theory to describe how the introduction of algorithmic management changes supervisory dynamics in traditional organizations. I will collaborate with five organizations spanning different industries and observe workers and supervisors to uncover their experiences of supervisory relationships. Subproject 2 will provide an articulated account of how algorithmic management changes managerial roles and practices, through interviews with a large sample of managers that implement algorithmic management. Subproject 3 will reveal how workers respond to conflicting directions from humans and algorithms. In this study, workers will participate in simulations of actual workplace dilemmas, created using immersive VR technology. Subproject 4 will address the mitigation of detrimental outcomes of algorithmic management through ethnographic action research. The proposed research will provide ground-breaking insights regarding the emerging yet unexplored phenomenon of algorit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'International Research Consortium on Dengue Risk Assessment, Management, and Surveillance' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The overall concept of this research project is to assemble a consortium of international experts working together to develop new and innovative tools to be applied to the control of dengue in a global context. The core of the application focuses on parallel strategies aimed at:•improving diagnosis and clinical management of dengue through two linked work packages designed a) to identify readily available clinical and laboratory parameters and/or viral and immunological markers, that differentiate between dengue and other common febrile illness within 3 days of fever onset, and b) to identify any of the available markers that are predictive of the likelihood of evolving to a more severe disease course•assessing the risk of dengue spread though linked work packages focused on a) mapping and modelling techniques to  define the current extent of dengue disease globally and to evaluate possible scenarios of spread or risk to previously uninfected regions in the future, and b) developing effective and affordable early warning and outbreak response systems.These four work packages are supported by a fifth work package dedicated to networking and translational activities to ensure that outputs from the various research activities are used to maximal advantage.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Gender and Diversity Index for a fair, competitive, resilient and sustainable Europe'.

assistant: **Objectives**

The GENDEX mission consists of the development of the Pilot Innovation Gender and Diversity Index, providing consistent information (currently missing or fragmented) to startups, scaleups, corporates, the EIC, other investors and funding bodies, market actors and policy makers across Europe. The overall aim is to improve the availability of all talent, particularly female talent, to the EIC portfolio of projects and companies and the EU innovation ecosystem. For the first time ever, a G&D Index will be elaborated including a wide range of indicators related to gender but also to diversity factors covering all European Member States plus the U.K. GENDEX will review the existing baseline and access a high number of data sources, but it will bring a unique value by carrying out additional primary research both at quantitative and qualitative levels. Data sets will be assessed, gaps will be identified, a more standard-based approach to data will be suggested, all resulting in a richer definition of indicators and hence a G&D Index that will become a reference in Europe supporting evidence-based decision-making. A full report on the Index will be released with complementary material, including a web-based interactive dashboard that will enable smart data visualizations and a widget that will be used for company self-assessment and as a potential data collection tool. A wide dissemination, communication and awareness campaign will be implemented to ensure engagement and maximize the adoption of the G&D Index.  The GENDEX consortium comprises a complementary set of recognized partners that includes IDC, European Women in VC and BluSpecs, authors of some of the key works in the field and also a guarantee of the best possible networks for stakeholder engagement. Such engagement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pulp and Paper Industry Wastes to Fuel' under Horizon 2020.

assistant: **Concept**

The transport sector is dominated by the use of fossil fuels, and alternative fuels represent currently only 5% of fuel consumption in EU. The EU objective for the share of renewable energy in the transport sector is 10% in 2020. To achieve this goal, new advanced biofuels are needed and must be produced from alternative feedstocks. The Pulp&Fuel concept is to develop a simple and robust fuel synthesis process taking advantage of the synergy between super critical water gasification (wet gasification) and fixed bed gasification (dry gasification). For the Pulp&Fuel project, we have chosen to study the integration of the full process on a pulp mill. The developed process will take advantage of low to negative value wet and dry resources on a paper mill to add value to the overall process. The yield of biofuels will be significantly increased to 28 % compared to a classic approach that would only yield 18 %.  The Pulp&Fuel final objective is to produce biofuels below 1 €/L without having a negative impact on the existing operations of the pulp mill. To achieve these goals a team of 10 partners, leaders in their field, from 4 EU-member states, will join efforts. To this end, we have defined five ambitious specific objectives: - Improve the efficiency of the dry gasification process from 70 to 80 % - Improve the carbon conversion of the wet gasification process to above 90 % - Improve fuel synthesis to obtain carbon efficiencies above 50 % (state of the art 45%) - Integration of the full process and synergy between dry and wet gasification - Integrated assessments will show that biofuels can be produced below 1 €/L Related work packages, tasks, milestones and risks are considered in order to achieve these objectives. The Pulp&Fuel project addresses the topic “liquid diesel-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Silicon Brillouin-assisted Optoelectronic Oscillator Based on Subwavelength Membranes'.

assistant: **Objectives**

Silicon-based technologies offer tantalizing prospects for low-cost mass production of high-performance optoelectronic circuits by leveraging the maturity of complementary-metal-oxide semiconductor facilities. However, the processing and generation of high-quality radiofrequency signals using optoelectronic oscillators is still hampered by the spectral response of Si filters, which are unable to provide a rejection band on the order of MHz. Stimulated Brillouin scattering (SBS) has been at the core of recent stunning demonstrations of key on-chip functionalities for microwave photonics, exhibiting several properties that are ideally suited to overcome the limitation of Si photonic filters. SBS interactions can be orders of magnitude stronger in suspended Si waveguides compared to conventional optical fibers, but approaches demonstrated so far are mainly limited by trade-off between phonon lifetime and photon-phonon overlap.This project will address a completely new route to overcome the trade-off between long phonon lifetimes and large photon-phonon overlap in conventional Si optomechanical waveguides. The original idea is to exploit the unique degrees of freedom released by subwavelength Si nanostructuration to achieve flexible control of the shape and dispersion of optical and mechanical modes in order to maximize optomechanical coupling and Brillouin gain. This approach will be used to demonstrate a Si optoelectronic oscillator that exploits the intrinsic narrow linewidth of the Brillouin effect to achieve three orders of magnitude phase-noise reduction compared to the state of the art. The SUNRISE technology will open a whole new research domain in integrated optomechanics with great opportunities for fundamental and applied research. The unique expertise combinatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel processing of colloidal nanocrystals for optoelectronic applications' (NANOPTO), addressing dissemination and exploitation.

assistant: **Impact**

NANOPTO aims at developing novel physicochemical routes to obtain a semiconductor matrix embedding dispersed quantum-dots (dots-in-matrix) starting from colloidal nanocrystals.In recent years, a multitude of different semiconductor materials have been synthesized and studied to  increase the performance of current technologies or to develop new and attractive applications. As a first-order approximation, materials boosting high photoluminescence (PL) quantum yield (PLQY)  possess low or hindered charge mobility, as pristine colloidal semiconductor nanocrystals (NCs). To overcome this limitation, many different NCs processing techniques have been developed, but all of them either cause the formation of charge trap-states on the NCs surface (thus quenching the PL) or do not significantly enhance the charge mobility. For this reason, NANOPTO will tackle this fundamental limitation of NCs by developing novel general methods to enhance their charge mobility without creating surface trap-states, thus leading the way to the development of more efficient light-emitting diodes (LEDs) and solar cells that can be processed in solution. In particular, NANOPTO aims at exploiting both chemical and physical routes to prepare colloidal core-shell NCs and solder their shells in solid-state thus creating a bulk semiconductor matrix (granting enhance charge mobility) embedding quantum-dots (granting the desired optical properties).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Operando studies of praseodymium based mixed oxide supported metal catalysts for the direct conversion of methane to methanol: bridge the gap of model catalysis and ambient applications' in the context of a Horizon Europe call.

assistant: **Objectives**

The direct conversion of methane to methanol (DCMM) has attracted strong interest due to its great potential use in the energy and chemicals sectors, at the same time diminishing the greenhouse effect. However, this process is challenging for heterogeneous catalysis due to the high energy required for cleaving the C−H bond in CH4, as wells as the facile over-oxidation of CH3OH to CO or CO2. Recent ultrahigh vacuum (UHV) studies indicate that metal-oxide surfaces/interfaces can facilitate DCMM with high selectivity at low temperature in a single batch mode. Inspired by the model studies, in this project we will synthesize a series of praseodymium mixed oxides supported Cu and Au catalysts (i.e. Cu-Au/Ce1-xPrxO2-δ, Cu-Au/Zr1-xPrxO2-δ) and explore its application for DCMM under ambient conditions. Major challenges in designing this system for DCMM is the identification of the active sites in the working state and correspondingly tailoring its properties, which can be overcome by using in situ/operando techniques and ‘defect engineering’. The catalytic performance will be investigated using both a batch (and flow) reactor and an operando spectroscopy cell. Near ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) and X-ray absorption near edge structure spectroscopy (XANES) will be used to determine the electronic state of the metals. Structure, including defects, of catalysts will be investigated by in situ X-ray absorption spectroscopy (XAS), X-ray diffraction (XRD), Selected Area Electron Diffraction (SAED) and Raman scattering. The reaction mechanism will be investigated by concentration-modulation Fourier transform infrared (FTIR) spectroscopy and operando Raman scattering. This study will provide strongly validated mechanistic and structural conclusions for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular and structural mechanisms for metazoan replication origin specification' (ORISPECIFICATION).

assistant: **Innovation**

Cellular life depends on the timely and accurate duplication of chromosomal DNA through semi-conservative replication to sustain genomic integrity and organismal viability. In all domains of life, DNA replication relies on dedicated initiator proteins that recognize and bind specific genomic sites, termed replication origins, to facilitate the loading of ring-shaped replicative helicases onto DNA. While origin recognition by initiators is determined by specific DNA sequences in prokaryotes and in the eukaryote S. cerevisiae, origin specification in higher eukaryotes instead appears to rely on chromatin context and DNA structure. Yet, how initiators help specify replication origins at the molecular level and how their binding sites are established in higher eukaryotes remain foremost and long-standing questions in the field. This research proposal focuses on uncovering the molecular and structural principles for chromosomal binding site selection by the eukaryotic initiator, the origin recognition complex (ORC), in metazoan systems. Employing integrated biochemical, structural, and cell-based approaches, we aim to 1) elucidate how ORC binds DNA and how DNA structural elements contribute to this interaction, 2) determine how nucleosomes are recognized by ORC, and 3) identify auxiliary binding partners of ORC and establish how they contribute to origin specification. The outcomes of our proposed efforts will have far-reaching implications for multiple scientific fields by defining mechanistic links between chromatin architecture and DNA replication initiation, and they will set the foundation to understand at the molecular level how the replication initiation program is altered during cell differentiation and development. Our studies also have significant biomedical releva