RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Molecular and pharmacology study of the transient receptor potential channel TRPV1'.

assistant: **Innovation**

The somatosensory system detects and integrates a large array of noxious stimuli of highly divergent nature. Members of the transient receptor potential (TRP) ion channel family play a pivotal role in the detection of innocuous and noxious stimuli, of both physical and chemical nature. Thus, elucidating the gating mechanisms of these channels is essential for our understanding of somatosensation and nociception. Taken the polymodal nature of those somatosensory TRP channels, our overall goal is to provide a comprehensive understanding of their activation mechanisms as evoked by various stimuli. TRPV1, a member of this family, detects a variety of pain-evoking molecules such as vanilloids (capsaicin), protons and animal peptide toxins. This activity is mediated by at least two distinct channel regions; each binds different set of activators. Despite its central role in pain perception, our knowledge of TRPV1 molecular mechanism of action is limited. Here, we propose to examine the stoichiometry and allosteric regulation of TRPV1 activation through its two distinct binding regions. Our working hypothesis is that because TRPV1 is required to detect and react to a large range of noxious stimuli, each of its ligand-binding regions evolved to induce a defined activation mechanism. We will use concatemeric rat TRPV1 harboring subunit-specific mutants, which will be expressed in heterologous systems. We will analyze for changes in TRPV1 activation by various ligands using specific electrophysiological assays designed to measure channel gating, combined with calcium imaging and biochemical assays. Overall, the proposed study will identify the allosteric regulatory mechanisms by which TRPV1 is activated through its distinct ligand-binding regions, mechanisms that ultimately under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Raising awareness amongst (young) people on the importance of research on aquatic ecosystems and pollution and the impact on food and health' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The project of the partnership between KATHO-HIVB (Higher Institute for nursing and biotechnology, Belgium) and the DDNI (Danube Delta National Institute for Research and Development, Romania) has two main objectives namely stimulating young people to stud y (life)sciences and to communicate the importance of scientific research to the public at large. The project is situated in three FP6 thematic priorities: 1) the life sciences in particular the field of biotechnology and eco-toxicology, 2) food quality an d safety and 3) sustainable management of ecosystems. The objectives will be achieved through various initiatives such as ?scientist for a day? activities in which young people will perform experiments in schools or in the partners Institutes. In these ex periments various aspects will be addressed such as fragile aquatic ecosystems (eg the Donau delta in Romania and the Yser area in Flanders Belgium), biodiversity, pollution and the impact on food quality and human health. The importance of innovative biot echnological techniques fi toxicity experiments with different modelsystems, GMOs as bioremediation, water treatment and phytoplankton experiments, ? will be stressed. Some aspects of genderissue (giving preference to schools with a minimum of 50% female s tudents) and ethical issues (fi the use of cell cultures instead of animals for toxicity tests) will be incorporated. Other activities programmed are workshops with young people and the public, meet and greet" activities and the making of the short movie 'Life of a scientist'. The activities fit well in the framework of the Researchers in Europe Initiative 2005 and the project will contribute to a better understanding of the researchers profession amongst young people and the public. The expertise of both insti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Role of the HspB8/Bag3 chaperone complex in neurodegenerative disorders' under Seventh Framework.

assistant: **Concept**

Molecular chaperones and degradation systems allow cells to cope with misfolded and genetically mutated proteins. The Hsp70/Hsp40 families and the members of the HspB family (HspB1-HspB10) recognize and bind misfolded proteins, prevent their aggregation and facilitate their degradation. Mutations in genes encoding several HspB proteins have been associated with neurological and muscular disorders, strongly supporting a critical role for these proteins in neuronal and muscular cell viability. For this project, we focus on HspB8, which is mutated in peripheral neuropathies. However the precise mechanisms leading to disease progression are largely unknown. Inversely, I found that upregulation of HspB8 in cell systems can ameliorate toxic aggregation of proteins related to polyglutamine diseases, like Huntington disease (HD) or Spinocerebellar ataxias (SCAs). Our data suggest that HspB8 plays a role in autophagy, which deregulation may contribute to neurodegeneration and which upregulation may explain its effects on HD and SCA. In these actions, I found that HspB8 cooperates in a non-canonical manner with Bag3, independent of its classical interaction partners Hsp70 and Bcl-2. I will further analyse connections of HspB8/Bag3 with other HspB members and how they influence autophagy using different in vitro approaches. Recently, we also identified the Drosophila HspB8 orthologue and show that it interacts with Starvin, the Drosophila Bag3 orthologue. This will allow us to evaluate the effects of the complex in vivo and to establish whether the progression of peripheral neuropathies is due to a toxic gain of function (overexpression of mutated HspB8) or to a loss of the HspB8 chaperone activity (knock-out of HspB8) and whether deregulated autophagy is involved in the developme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'TRANSITION FROM LINEAR 2 CIRCULAR: POLICY AND INNOVATION' (R2PI).

assistant: **Innovation**

R2π examines the shift from the broad concept of a Circular Economy (CE) to one of a Circular Economy Business Models (CEBM), by tackling both market failure (business, consumers) and policy failure (conflicts, assumptions, unintended consequence). Its innovation lies in having a strong business-focus, examining stimuli beyond environmental goals (including ICT and eco-innovation), and in examining the role of policy innovation (including the use of policy nudges and of ""Policy Packages""). R2π unfolds in diverse contexts with a strong emphasis on involvement and exchange. The research design employs mixed-methods, with a strong emphasis on case studies but also including desktop research, feasibility assessments (including surveys where applicable), policy formulation & stakeholder involvement. The ultimate goal of the project is to see the widespread implementation of the CE based on successful Business Models to ensure sustained economic development, to minimize environmental impact and to maximize social welfare. The goal of the R²π project is therefore to develop sustainable business models that would facilitate the circular economy and to propose ""Policy Package"" that will support these business models. The R2Pi Consortium consists of 14 partners from 9 Member states and associated countries. The wide range of expertise, knowledge, tools and connections existing among the consortium members will be leveraged to develop innovative practical tools and procedural guidelines that may be widely and systematically applied across many different business sectors in diverse regions and countries, across the spectrum from large established EU countries to newer and smaller member states.. Through these innovative business models and ""Policy Packages"", the European econ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'LINKING AGEING, DIET AND SKELETAL DEGENERATION: ROLE OF LONGEVITY-GENE SIRT1 IN THE MAINTENANCE OF MUSCULOSKELETAL INTEGRITY WITH AGE""' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The ageing process is inexplicably linked to bone loss. This skeletal deterioration occurs in both sexes across all ethnic backgrounds and as such represents a major healthcare challenge worldwide. By increasing our understanding of how the ageing process impacts physiological systems, we can begin to develop novel therapeutics for the prevention and treatment of age-related disorders, such as osteoporosis and arthritis. We propose that common factors exist that control both Ageing and Bone and so link increasing age with a generalised decrease in bone mass. The sirtuin family of longevity associated genes regulate lifespan in lower organisms. SIRT1 is the predominant mammalian sirtuin, is strongly linked to cell survival and proliferation and regulates factors common to both ageing and bone. Recently we have made the novel discovery that SIRT1 expression declines with age and mice deficient in the SIRT1 gene have decreased bone mass and strength, similar to that seen in ageing humans. This decreased bone volume was the result of an uncoupling of the equilibrium between osteoclastic resorption and osteoblastic bone formation, a fundamental mechanism in the onset of osteoporosis. Moreover, SIRT1 expression can be induced and age-related bone loss prevented by the use of a strict dietary regime, suggesting common mediators in bone homeostasis and energy metabolism. Our overall hypothesis is that SIRT1 links diet and bone remodeling to preserve bone mass with age and control musculoskeletal deterioration. Specifically, this application will assess the role of SIRT1 in human bone tissue, stem cell commitment, bone cell function and microstructural, compositional properties of the skeleton. In addition, mechanistic studies will explore SIRT1 interactions with target proteins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DEVELOPMENT OF A SPIRAL LAMINAR FLOW INDUCING ENDOVASCULAR STENT FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE' in the context of a Horizon 2020 call.

assistant: **Objectives**

The project is focused the medical device sector and specifically peripheral vascular (PV) devices. A large, unmet, and growing patient population will require treatment for Peripheral arterial disease (PAD) and revenue in this market will continue to grow driven by the aging population and the increased incidence of obesity and diabetes. Percutaneous transluminal angioplasty (PTA) is the most widely used non-surgical treatment, however when used in areas of long calcified stenosis, PTA does not show satisfactory results at long term follow up. Stenting has become the most obvious choice to overcome the limitations of PTA. Unfortunately, long term performance of stents appears to be problematic as they do not prevent (and may to a certain extent even cause) a failure mode known as restenosis. Whilst covered stents have tackled the problem of restenosis within the stent the stent itself interrupts the bloods natural spiral laminar flow (SLF) and increases laterally directed forces and wall shear stress downstream of the implantation causing downstream disease progression. Re-institution of the bloods SLF reduces the forces and turbulence caused by stenting, and reduces neointimal hyperplasia (NIH) distal to the stent which can lead to occlusion distal to the stent.The global objective of the project is to develop an innovative endovascular stent that will reintroduce the natural spiral laminar flow both through the stent and distal to the stent that can be manufactured to be deployed using standard delivery system profiles. With the long term post project target of increasing patency rates to greater than 80% and reduce restenosis of the stent by greater than 20% and distal stenosis by greater than 20% at 2 year follow up. As a result of the proposed project, we expect t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'An Environmental History of Haiti (1492-present)'.

assistant: **Innovation**

This project will aim to reinforce the international dimension of the applicant's career and give him the opportunity to be professionally trained in the United States as an Environmental Historian. He will acquire new knowledge and research methods and will return to the EU well-equipped to teach and publish in this relatively new field of study, still under-represented in Europe. The project will fill in a void in scholarly research by producing the first Environmental History of Haiti since 1492. The monograph will attempt to explain why Haiti is now one of the most environmentally degraded and poorest countries in the world, whilst it was in the 18th century a luxuriant island and the leading exporter of sugar in America. Existing academic works on Haiti are mostly centred on one particular aspect of the history of the country, are circumscribed in time and almost always neglect the environment when attempting to explain the nation's tortured past. This project's working hypothesis is that environmental factors have played a much more significant role than is currently recognized. For example, the pattern of population and colonisation of the island, which has played such a significant role in the country’s history, was severely constrained not only by the slave-based plantation economy, but also by the work of humble mosquitoes, vectors of yellow fever and malaria. Environmental degradation today (deforestation, soil erosion…) also plays a crucial role in the chronic instability of the country. The project will be carried out in Washington D.C. and Paris under the guidance of two leading scholars in the field, John McNeill (Georgetown University) and Genevieve Massard-Guilbaud (EHESS). The applicant will take advantage of the rich resources available for his resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Multimedia Teacher Training Network'.

assistant: **Objectives**

REM will develop a telematics service for joint teaching and learning about Europe by teachers and students, using networks and multimedia resources to facilitate their wider contact with foreign counterparts. The system will be piloted for trainee teachers, in-service teacher training and nursery staff. Support for project activities will include a distributed database of multimedia training materials, and tools to assist in processing the data, and its conversion into course material. Training and information material for in-service staff and their establishments will be developed, alongside plans for further promotion of activities. More than 900 teachers and students from 9 countries will participate in the project.The project will provide a telematic system for collaborative teaching and learning across Europe. In particular it will allow teachers and students to work together to study and develop their teaching about Europe using a range of networks and multimedia resources. The project will aim to provide opportunities modelled on EC programmes ERASMUS and COMENIUS which give students and teachers opportunities to gain experience from wider contact with their European counterparts. Through telematic technology we will a much wider access to European collaborative teaching and learning. The system will allow students to study in their homes or schools as well as in IHE's. For trial purposes the project will develop the system for teachers in training, teacher in service courses and the professional development of nursery staff. The project will be tested on 968 students and teachers in at least 9 EC member states.To facilitate these activities we will- create and maintain a distributed database of multimedia learning/training materials,- develop technological tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Electrobioanalytical Applications of Polyoxometalates' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The proposed work will exploit the expertise and know-how of the host institute and the fellow to develop a strategy for the detection and screening of genetic mutations in a highly parallelised fashion.The project has an overall objective to develop an electrochemical single nucleotide polymorphism (SNP) detection strategy by using polyoxometalate (POM) labeled DNA (including PCR primers, dNTPs and ddNTPs) for use in solid-phase melting curve analysis and sold-phase array based primer extension and solid phase ligase mediated detection.  In order to achieve this, robust surface for anchoring of DNA probes capable of withstanding elevated temperature for enzymatic reactions either in solid phase melting curve analysis or single dideoxynucleotide incorporation will be developed. The proposed strategies will allow for highly cost-effective, rapid and user-friendly platforms for the screening of genetic mutations and single nucleotide polymorphisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Clean Hydrogen in European Cities'.

assistant: **Objectives**

The Clean Hydrogen in European Cities (CHIC) Project is the essential next step to full commercialisation of hydrogen powered fuel cell (H2FC) buses. CHIC will reduce the ‘time to market’ for the technology and support ‘market lift off’ – 2 central objectives of the Joint Undertaking.CHIC will:- Intensively test the technology to generate learning for the final steps towards commercialisation by operating a minimum of 26 H2FC buses in medium sized fleets in normal city bus operation, and substantially enlarging hydrogen infrastructure in 5 European regions.- Embed the substantial knowledge and experience from previous H2FC bus projects (CUTE & HyFLEET:CUTE).- Accelerate development of clean public transport systems in new European Regions.- Conduct a life cycle based sustainability assessment of the use of H2FC buses in public transport, based on a triple bottom line approach considering environmental, economic and social aspects.- Identify the advantages, improvement potentials, complementarities and synergies of H2FC buses compared with conventional and alternative technologies- Build a critical mass of public support for the benefits of ‘green’ hydrogen powered transport, leading to increased visibility and political commitment across Europe.The project is based on a staged introduction and build-up of H2FC bus fleets and the supporting infrastructure across Europe. A phased approach will link experienced cities and new cities in partnerships, greatly facilitating the smooth introduction of the new systems now and into the future. Using this arrangement the project will be linked to other projects fully funded from other sources and therefore magnifies the impact of the JTI.In the context of the H2FC bus projects and progress achieved to this point, the expected resu