RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Computational design of novel functions in helical proteins by deviating from ideal geometries' (HelixMold).

assistant: **Innovation**

We propose to computationally design novel ligand binding and catalytically active proteins by harnessing the high thermodynamic stability of de novo helical proteins. Tremendous progress has been made in protein design. However, the ability to robustly introduce function into genetically encodable de novo proteins is an unsolved problem. We will follow a highly interdisciplinary computational-experimental approach to address this challenge and aim to:-Characterize to which extent we can harness the stability of parametrically designed helical bundles to introduce deviations from ideal geometry. Ensembles of idealized de novo helix bundle backbones will be generated using our established parametric design code and designed with constraints accounting for an envisioned functional site. This will be followed by detailed computational, biophysical, crystallographic and site-saturation mutagenesis analysis to isolate critical design features.-Develop a new computational design strategy, which expands on the Crick coiled-coil parametrization and allows to rationally build non-ideal helical protein backbones at specified regions in the desired structure. This will enable us to model backbones around binding/active sites. We will design sites to bind glyphosate, for which remediation is highly needed. By using non-ideal geometries and not relying on classic heptad repeating units, we will be able to access a much larger sequence to structure space than is usually available to nature, enabling us to build more specific and more stable binding/catalytically active proteins.-Investigate new strategies to design the first cascade reactions into de novo designs.This research will allow functionalization of de novo designed proteins with high thermostability, extraordinary resistanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fostering European Talents for Widening Circular Economy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Talent Pass initiative is designed to: - strengthen the innovation ecosystem towards a borderless research, innovation (R&I) and technology market by addressing the critical need for geographically balanced talent circulation and increased cross-sectorial interoperability, as outlined in Action 4 of the ERA Policy Agenda (2022-2024);- cultivate and support cross-sectorial partnerships between academic and non-academic organizations that operate in areas of proven scientific excellence, particularly within the realm of the circular economy. The Talent Pass project aims to: - significantly enhance talent mobility and expertise development within circular economy, particularly focusing on researchers, innovators, and other R&I academic/non-academic talents from widening countries; - build a critical mass of competent researchers having the necessary high-quality knowledge, skills, and tools to drive forward innovation and sustainability in the circular economy; - improving access to excellence by consolidating an interdisciplinary network of highly skilled human resources and enhance the efficient utilization and valorization of complementary research capacities, infrastructure and results, aligning with the Horizon Europe Work Program (2023-24) - WIDERA and the Circular Economy Action Plan for a Cleaner and More Competitive Europe (2020);- bridge the gap between research and application and effectively translate advancements in circular economy into real-world solutions, by fostering collaboration between academia and industry. Talent Pass will subsequently focus on strengthening the research capabilities of WC institutions, ensuring they are on par with leading European entities. This will be achieved through strategic use of research resources (human, know-how and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The svedberg laboratory' in the context of a Fifth Framework call.

assistant: **Objectives**

Description:The Svedberg Laboratory (TSL) is a Swedish national facility operating two accelerators, a cyclotron and a storage and cooler ring. The cyclotron acts as the injector to the CELSIUS ring, but can also be run separately giving a wide range of ion beams of various energies up to 185MeV for protons and 8MeV/nucleon for xenon ions. In the beam lines of the cyclotron there are various detector systems for charged particles, neutrons and gamma radiation. One of the beam lines contains a facility for mono-energetic neutron beams of energies between 25 and 180MeV and intensities up to one million per sec. The CELSIUS ring is a synchrotron, giving maximum energies of 1.36GeV for protons and 470MeV/nucleon for light ions (A < 40) with a charge-to-mass ratio of 1/2. The main activity at the CELSIUS ring is the study of light meson production and decay. The pions and eta mesons are produced in light-ion collisions and the decay products are recorded in a large-solid-angle detector, WASA, located in one of the straight sections of the CELSIUS ring.Application:Scientists interested in using the TSL facilities are recommended to contact the Scientific Coordinator, Dr Hans CalTn (phone: +46-18-4713846, e-mail: calen@tsl.uu.se). Proposed research projects are evaluated by the TSL program advisory committee (PAC), which also acts as the User Selection Panel (USP) for projects asking for support from the European Commission. The PAC/USP meets twice a year, normally in May and October. Deadlines for proposals are March 15 and September15.Project Manager:Curt Ekström, The Svedberg Laboratory, Thunbergsvägen 5A, Uppsala 751 21, P.O. BOX 533, SwedenTel: +46-18-4713112Fax: +46-18-4713833E-Mail: ekstrom@tsl.uu.se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Single-Chip Integration of MEMS Micropumps with Optical Waveguides for Laser Absorption Spectroscopy' (VacLAS-Chip).

assistant: **Concept**

Microbiological research is concerned with studies of microbial gas consumption and production, which is tightly linked to natural greenhouse gas emissions, but also sinks. Currently, such studies require large and expensive instrumentation like gas chromatography systems, which also sacrifice the sample during each measurement. This affects the conditions of the sample, and yields unsatisfactory temporal resolution due to the need for sample handling. In this project, I propose to leverage the latest advances in MEMS and nanophotonics to develop the first chip platform integrating optical waveguides with micropumps, which will facilitate tuneable diode laser absorption spectroscopy (TDLAS) under vacuum and in closed valume without sacrificing the sample gas. With the addition of lasers and light detectors, it will enable inexpensive, low weight, portable devices for real-time, in situ trace gas detection. Such device will not only impact microbiological research, but also sensor networks much needed e.g., in cities for controlling the air quality.


**Keywords:** Micro-electro-mechanical systems, Gas microfluidics, Laser absorption spectroscopy, TDLAS, Gas spectroscopy,  Low-pressure gas spectroscopy, MEMS pumps, Micropumps, Microfluidics, Nanophotonics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on '4F-induced rejuvenation of glia into neural stem cells for brain repair'.

assistant: **Concept**

Although the concept of adult neurogenesis has important implications for regenerative medicine, the formation of new functional neurons from progenitors during adult life is rare and occurs only in confined areas of the mammalian brain . Because adult neurogenesis is limited, the regenerative capacity of the brain is restrained and the possibilities of recovery from damage are almost absent. The WHO* reported that up to 1 billion people, nearly one in six of the world’s population, suffer from neurological disorders. Many of these disorders have the loss or malfunction of neurons in common. Alongside the rapid increase of life expectancy whereby it is estimated that a quarter of Europeans will be over 60 years of age by 2020, these types of disorders are becoming a growing burden for aging societies, in terms of both suffering and economic cost. In Europe, for example, the total cost of brain disorders was estimated at €386 billion in 2004 and increased to €798 billion in 2010.This project, 4F4REJUVENGLIA (short for: 4 factors for rejuvenating glia), focuses on a novel approach to engineer neurogenesis, based on nuclear cell reprogramming technology, to induce regeneration of damaged areas of the brain. The aim is to generate new neurons in regions naturally devoid of neurogenesis. The approach involves the overexpression of the Yamanaka factors directly in parenchymal glia, with the purpose of reprograming/rejuvenating these cells back in development in order to recover their stem cell potential lost during specification (Fig.1). We hypothesise that this “rewinding” to a neural progenitor-like state may rearrange the local environment and remodel it towards a stem cell niche that help instruct and integrate new neurons within the preexisting circuits.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Towards rational design of cancer therapeutic drugs: a first principles study of the photosensitization mechanism of methylene blue (Photoblue)' in the context of a Seventh Framework call.

assistant: **Objectives**

Cancer is a severe health problem and thus the development of effective cancer drugs is one of the first priorities of the European Research Area. Photodynamic therapy (PDT) is a well-recognized process to treat cancer where cell death is caused by the effect of singlet molecular oxygen acting on molecular constituent parts of the cell. The most common way to generate singlet molecular oxygen requires the interaction between a photoexcited triplet photosensitizer and ground state molecular oxygen and, often, a biological compound. The general aim of Photoblue is to unravel the process of photosensitization in PDT by studying theoretically the photosensitizer methylene blue and its interplay with the environment. Methylene blue is selected because it is small to be studied theoretically and its photosensitization mechanism is unknown. To achieve this aim we propose a combination of state-of the-art quantum chemistry and a multilayer hybrid quantum mechanical/molecular mechanics (QM/MM) molecular dynamics technique that will allow a novel understanding of this light-activated process on the atomic level. The dynamical calculations will be performed in the presence of water, molecular oxygen, and DNA in order to mimic a realistic biological environment. Conducting the proposed research will train the applicant in i) using the most advanced ab initio methods to describe ground and electronic excited states and ii) developing molecular dynamical methods to obtain time-resolved information. The coaction of the host group experience in excited state electronic structure calculations and molecular dynamical simulations together with the applicant’s extensive experience in modeling large systems with MM force fields guarantees the feasibility of this challenging project. The exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sewage chemical information mining – development of a novel concept for the assessment of human exposure to pollutants through wastewater analysis' under Horizon 2020.

assistant: **Concept**

Human populations worldwide are exposed to a large number of chemical pollutants from contaminated food, personal care products and the surrounding environment. Exposure to these compounds is generally assessed by human biomonitoring - the analysis of biomarkers (excreted parent compounds or metabolic products) in biological matrices from individuals, mostly urine. Due to the several limitations of this approach, a novel concept - sewage chemical information mining (SCIM), has been proposed. This approach is based on the analysis of specific human biomarkers in urban wastewater, but its potential in studying human exposure to pollutants has been scarcely investigated.The SCHEME project aims to contribute to the practical development and broadening of the SCIM field by developing a comprehensive analytical methodology for the determination of biomarkers of exposure to a wide range of organic pollutants, including different classes of personal care products and industrial chemicals. The biomarkers will be selected using the pharmacokinetics data and Human Metabolome Database and analysed by ultrahigh performance liquid chromatography - tandem mass spectrometry. The developed methodology will be applied in four European cities as case studies. However, the results of this exploratory study could lead to implementation of this novel, relatively inexpensive and near real-time approach for the assessment of human exposure to pollutants. By monitoring temporal and spatial trends, communities with the highest exposure could be promptly identified. Therefore, the results of the SCHEME project will be highly valuable for obtaining relevant epidemiological information and will contribute to preventing human health problems related to pollutants exposure. The fellow’s expertise, ga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhancing material CIRCularity and Lower Emissions of Ship building processes in all phases of the LIFE cycle' (CirclesOfLife) targeting Horizon Europe.

assistant: **Abstract**

The market conditions and the regulatory framework for the shipping industry and shipyards are changing profoundly. In response, shipyards need to build up the capacity to assess the environmental footprint of their yard-activities and the ship to inform their stakeholders in a transparent, understandable, comprehensive, and trustworthy way. While the environmental footprint of the operational phase of a ship can be covered sufficiently by existing standards, the non-operational footprint of the shipyard processes and the integrated materials and components remain a black box. It is the ambition of this project to drastically change the as-is situation and to make the impact measurable and thereby drive progress toward circular, zero impact shipping over the full circle of life of a ship. Therefore, CirclesOfLife will develop, test, and validate a general methodology and framework applicable to all European shipyards enabling to close the gaps in assessing the environmental performance of the shipyards and the ships they design, build, maintain, retrofit or recycle. CirclesOfLife will go beyond state of the art by defining a scientifically sound SEPI-methodology and Cradle2Cradle Ship Passport and will test and validate its applicability in day-to-day business of shipyards and suppliers in several use-cases, ranging from new building- to repair-and maintenance- to recycling yards. Moreover, CirclesOfLife follows a clear pathway towards market introduction and societal impact supported by Surfrider and ShipBreaking Platform as independent and trustworthy NGO’s. Based on the described measures, CirclesOfLife pursues to offer a widely accepted standard enabling shipyards, maritime equipment manufacturers, shipping companies, finance institutions and other stakeholders to c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Large scale elucidation of the biological functions of the Staphylococcal RNome in genetic hybrid systems' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Every year in the European Union, an estimated 25000 patients die because of a serious resistant bacterial infection acquired in hospital. The bacterium Staphylococcus aureus is a main opportunistic pathogen responsible for food poisoning, skin infections and nosocomial infections. In the recent years, small ribonucleic acids (sRNAs) have attracted great interests as ubiquitous regulators.  Some of them have been directly related to commitment of virulence of this species. However, a serious bottleneck in unraveling their biological roles is due to the difficulty in identifying targets of the RNome (any non-conventional RNA with regulatory functions). There is a strong and urgent need to propose and use novel technologies for target detections of the bacterial RNomes. SarHyb intends to identify the primary molecular targets of staphylococcal RNome with a multidisciplinary approach. Therefore, t will combine the use of novel bacterial genetic hybrid systems, molecular biology and biochemistry. The researcher has an in depth expertise in the use or large-scale studies and yeast as a surrogate system which he used during his postdoctoral training at Yale University (USA). The main objective of SarHyb is to provide a list of prioritized sRNA candidates to target for the development of novel drug therapy directed against this pathogen. The transfer of knowledge from the researcher will consolidate the position of the host institution as a leader in Europe and worldwide in the use of hybrid-systems.Major Scientific findings expected during the course of the project include the development of the first bacterial hybrid systems devoted to RNA-target identification, an exhaustive list of mRNA and proteins directly regulated by sRNAs, and an in-depth understanding of the molecula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Learning the origins of temperature-sensivity in nervous systems' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Temperature influences living organisms at all the levels, from the rates of biochemical reactions within their cells up to their overt behaviour. Being fundamental to the physiology, animals evolved nervous systems capable of sensing temperature influencing in turn the behaviour (e.g., shivering when it is too cold). Cnidarians (like jellyfishes or corals) represents the second phylum in the animal kingdom endowed with a nervous system. Despite the many advancements in the field of thermal neurobiology, whether cnidarians possess neurons able to sense temperature is currently unknown. Acquiring this information and learning the modality of temperature-sensing would shed a light on the functions of the nervous system of the last common ancestor of cnidarians and bilaterians. With ThermoSensO, the researcher wants to address this question studying the temperature sensitivity in Hydra magnipapillata and Nematostella vectensis, two related classes of cnidarians. The transparency of their body, the public availability of their genome, and their phylogenetic position, make the two species very attractive animal models for this task. By associating behavioural testing with in vivo calcium-imaging and electrophysiology during delivery of thermal stimuli, the researcher wants to detect and characterise temperature-sensitive neurons and their role in these organisms. One of the most powerful tools to understand Biology is the comparison between species (e.g., Darwinian evolution theory). By providing to the scientific community a means of comparison with investigations in bilaterians and probing such an unexplored ground, ThermoSensO would give a very strong impulse to the field of thermal neurobiology and to the study of early nervous systems.


**Keywords:** temperature-sensin