RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next Generation Chiral Fluorine Groups for Molecular Design' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Fluorinated motifs have enormous societal relevance due to their ubiquity across the pharmaceutical, agrochemical and materials science sectors. These essential structural components feature prominently in the World Health Organization’s (WHO) list of essential medicines, and contribute to global food supplies by optimising the performance of many key agrochemicals. Similarly, our reliance on (polyfluorinated) materials ranging from non-stick Teflon® through to smart materials underscores the versatility of fluorinated groups in functional small molecule design. The historic success of fluorinated groups in societally-important molecules, coupled with scarcity of organofluorine building blocks in nature, continues to create a powerful impetus to develop more efficient and sustainable methods to facilitate their construction. However, the environmental impact of perfluorinated materials has come under scrutiny due to the persistence of the materials in the environment. The recent proposal by the European Parliament to address the persistence of perfluoroalkyl and polyfluoroalkyl (PFAS-type molecules) in water supplies covers ""any substance that contains at least one fully fluorinated methyl (CF3) or methylene (CF2) without any H, Cl, Br, or I attached to it."" Fluorinated groups that simultaneously conform to new legislative guidance, no longer pose an environmental threat and open up new areas of space for discovery will be generated efficiently. Through the intervention of ChiroFluor, unique structural entities such as the BITE group will be forged in both enantiomeric forms (handedness) to push chemical space beyond the existing boundaries. This project will simultaneously address a pressing environmental and legislative issue in a sustainable manner using an organoc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modelling and optimal design of refractories for high-temperature industrial applications for a low carbon society' in the context of a Horizon 2020 call.

assistant: **Objectives**

Population growth is combined with unprecedented improvements in standards of living for developing countries so that a massive demand for steel is expected for the construction of new infrastructures. This is going to produce a massive waste of energy and CO2 emission which cannot be tolerated by the world’s ecosystems. Indeed, steel production requires enormous amounts of energy and resources and consequently is a major source of pollution in terms of CO2 emission and waste production.Therefore, improvement and optimization of steel production targeted to sustainability and to the reduction of its eco-footprint are of crucial importance, if Europe is to maintain on the one hand its own steel industry and the environmental challenge on the other. In this sector (and others which deal with high-temperature liquids, e.g. aluminium, glass, molten salts in thermal solar power stations) the performance of refractory materials and related components plays a key role in energy efficiency, waste reduction and processing times.In order to drastically reduce the overall CO2 emissions from the production of steel, the development of breakthrough technologies is crucial.The overarching objective of the RE-FRACTURE2 project is to derive new computational models for refractory materials, which will make possible for the first time to simulate in-silico their behaviour over the whole of working temperature range. These models will be a breakthrough in the design of components like refractory nozzles, plates, ladle and tundish slide gate systems, which will directly translate to energy savings, waste reduction and decreases in pollution and CO2 emission, together with safety improvements.This goal will be achieved by the training of a new generation of “environment enthusiast designer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mentoring for School Improvement' under Horizon 2020.

assistant: **Concept**

The Mentoring for School Improvement (MenSI) project aims to mobilise 120 schools in six countries [Belgium/Flanders, Croatia, Czech Republic, Hungary, Italy, Portugal] to advance whole-school digital innovation to address both the general challenge of mainstreaming ICT at an institutional level as well as a set of more specific common challenges faced by national ministries of education, for example related to small/rural schools, social disadvantaged students, or challenges associated with personalising learning.Over 28 months project partners will:•Investigate and assess mentoring theories and practices (WP2);•Build and animate communities of practice based on 4 digitally advanced schools in each country, each mentoring four developing schools using a range of support models (WP3);•Support and train advanced schools in whole-school mentoring (WP4);•Document and analyse mentoring practices, scalability and effectiveness (WP5);•and Disseminate and sustain the networks through the Mentoring Policy Exchange awareness-raising platform and a Whole School Mentoring Massive Open Online Course (MOOC) (WP6).The foundations of the project will build mostly upon qualitative investigations of models of mentoring theory and practice and an analysis of policy related to whole school mentoring approaches mainstreaming ICT practices. Subsequently, partners will leverage their extended networks of schools for a “bottom-up diffusion of innovation through school-to-school peer learning” in regional hubs activated by the MenSI project. This knowledge on policy and practice will lead to recommendations and guidelines for mainstreaming mentoring practices which will be exploited by the Mentoring Policy Exchange and a MOOC for teachers. By the end of the project an inclusive European networ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The european virtual institute for thermal metrology' (EVITHERM).

assistant: **Innovation**

European centres of excellence operating in the field of thermal metrology offer technical expertise and research and development capabilities that are world class. However they are geographically scattered and the information and expertise they offer is not uniformly accessible to all potential industrial beneficiaries. This results in less efficient, less competitive and more environmentally polluting industrial products and processes. EVITherM will address this problem by creating a coordinated, Internet based infrastructure, which is a focal point for European organisations operating in the thermal metrology field. It will provide a forum for the interchange of ideas and technology between members and will disseminate new measurement techniques, best practice and research outputs to industry to increase the skill level of its workforce and improve its products and processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flexible nanowire devices for energy harvesting' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The goal of NanoHarvest is to explore novel solutions for flexible photovoltaic and piezoelectric converters enabled by semiconductor nanowires. The first objective is to demonstrate an innovative concept of flexible solar cells based on free-standing polymer-embedded nanowires which can be applied to almost any supporting material such as plastic, metal foil or even fabrics. The second objective it to develop high-efficiency flexible and compact piezo-generators based on ordered arrays of nanowire heterostructures. The crucial ingredient - and also the common basis - of the two proposed research axes are the advanced nanowire heterostructures: we will develop nanowires with new control-by-design functionalities by engineering their structure at the nanoscale. The main focus of NanoHarvest will be on the III-nitride semiconductors, which are characterized by a strong piezoelectric response and have also demonstrated their ability for efficient photon harvesting in the blue and green parts of the solar spectrum. Our strategy is to address the physical mechanisms governing the energy conversion from the single nanowire level up to the macroscopic device level. The deep understanding gained at the nanoscale will guide the optimization of the device architecture, of the material growth and of the fabrication process. We will make use of Molecular Beam Epitaxy to achieve ultimate control over the nanowire morphology and composition and to produce control-by-design model systems for fundamental studies and for exploration of device physics. The original transfer procedure of the ordered nanowire arrays onto flexible substrates will enable lightweight flexible devices with ultimate performance, which will serve as energy harvesters for nomad applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular Subtype Specific Stem Cell Dynamics in Developing and Established Colorectal Cancers' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Annually 1.2 million new cases of colorectal cancer (CRC) are seen worldwide and over 50% of patients die of the disease making it a leading cause of cancer-related mortality. A crucial contributing factor to these disappointing figures is that CRC is a heterogeneous disease and tumours differ extensively in the clinical presentation and response to therapy. Recent unsupervised classification studies highlight that only a proportion of this heterogeneity can be explained by the variation in commonly found (epi-)genetic aberrations.  Hence the origins of CRC heterogeneity remain poorly understood.The central hypothesis of this research project is that the cell of origin contributes to the phenotype and functional properties of the pre-malignant clone and the resulting malignancy. To study this concept I will generate cell of origin- and mutation-specific molecular profiles of oncogenic clones and relate those to human CRC samples. Furthermore, I will quantitatively investigate how mutations and the cell of origin act in concert to determine the functional characteristics of the pre-malignant clone that ultimately develops into an invasive intestinal tumour. These studies are paralleled by the investigation of stem cell dynamics within established human CRCs by means of a novel marker independent lineage tracing strategy in combination with mathematical analysis techniques. This will provide critical and quantitative information on the relevance of the cancer stem cell concept in CRC and on the degree of inter-tumour variation with respect to the frequency and functional features of stem-like cells within individual CRCs and molecular subtypes of the disease. I am convinced that a better and quantitative understanding of the dynamical properties of stem cells during tumou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Connecting the animal genome, gastrointestinal microbiomes and nutrition to improve digestion efficiency and the environmental impacts of ruminant livestock production' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project will integrate at the highest possible level expertise and technologies to increase the efficiency and decrease the environmental footprint of ruminant production, significantly advancing current knowledge in this sector. The project will exploit state-of-the-art –omics technologies to understand how ruminant gastrointestinal microbial ecosystems, or microbiomes, are controlled by the host animal and by the diet consumed, and how this impacts on greenhouse gas emissions, efficiency and product quality.  New models and tools will be developed to enable the livestock industry to decrease environmental damage from methane and nitrogen emissions, and to improve efficiency of feed utilisation.  A large-scale genetic association study involving 1000 dairy cows will relate feed intake, digestion efficiency, milk production/composition and methane emissions to the ruminal microbiome and host genome, leading to new indicator traits and tools for use in both traditional and genomic selection. Cow-reindeer metagenomic studies will establish how host species influence ruminal microbiology and function.  Bovine twins studies will define how the rumen microbiome varies in an identical host genetic background. Nutrition work will assess how dietary oils, nitrogen and carbohydrates affect the ruminal microbiome and product quality. A meta-barcoding 16S rRNA analysis protocol will be developed to investigate ruminal microbiomes more accurately, rapidly and cheaply. Saliva and faeces will be analysed as possible tools for non-invasive assessment of ruminal microbiome and function. A novel method for on-farm methane analysis will be refined for easy application. Results will be publicly available through an online data warehouse that will provide tools to build new queries an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Ambient Intelligence and Knowledge-Based Services for Optimal Life-Cycle Impact of Complex Manufacturing and Assemby Lines' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

InLife project will explore how a combination of advanced Ambient Intelligence (AmI) and Knowledge Management (KM) technologies can be used to assure a sustainable and safe use of manufacturing and assembly lines (MAL) and their infrastructure over their life-cycle. InLife specifically will improve the whole service-life operational costs and impact of MAL, providing new ways to monitor on-line Life-Cycle Parameters of MAL and improved services to support MAL along its whole life-cycle. To achieve these strategic objectives the project will provide: (a) new InLife methodology on how to apply a combination of AmI technology integrated in manufacturing processes and KM solutions to provide services and optimise life-cycle management of a MAL, addressing organisational issues regarding cooperation strategy within the extended enterprise (EE) concept, and (b) generic and widely applicable, modular Life-Cycle Management System (LCMS) based on multi-agent technology. These approaches will provide cost and time effective ways to collect higher amount of information/knowledge that up to now were practically impossible to acquire. The main originality lies in an effective combination of AmI and KM technologies to optimise life-cycle of complex MAL. AmI information and knowledge gathered within an EE environment along different life-cycle sectors of a MAL represent an untapped resource for optimisation of life-cycle of industrial installations and processes and for provision of services over the whole life of MAL. The InLife system and methodology will be tested by different business cases with end-users and vendors in the consortium, addressing different manufacturing concepts: highly automated and a combination of manual and automation MAL. The project will provide as exploitab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural investigation into functionality of Chikungunya virus nsP2 in replication complex and screening of small molecules for its inhibition' (CHIKV-FBDD) targeting Horizon 2020.

assistant: **Abstract**

Chikungunya virus (CHIKV) is a medically important pathogen that affected millions of people around the world. CHIKV infection causes high fever, intense joint pain and often leads to chronic virus-induced arthritis, thus there is a clear necessity to develop antiviral compounds capable of eliminating persisting virus. CHIKV is an alphavirus from Togaviridae family with single-stranded positive-sense RNA genome, which replication is carried out by a complex of four viral non-structural (ns) proteins, initially produced in a form of ns-polyprotein precursor and released by proteolytic processing. Because multifunctional nsP2 plays a central role in a replication cycle of CHIKV by exhibiting various enzymatic activities and counteracting cellular defence mechanisms, it represents the most attractive target for drug design and screening. Currently, the structural information regarding CHIKV ns-proteins is limited, whereas the platforms for in vitro testing the potential inhibitors are largely non-existent. Therefore the first aims of this project will be to apply structural biology approaches to elucidate spatial organization of nsP2 and to reveal its contacts with other ns-proteins in the replication complex. The druggability of nsP2 will be then explored by screening recombinant proteins against libraries of chemical fragments and characterizing binding of small molecules using sensitive biophysical techniques and crystallographic analysis. The potential of selected compounds to interfere with enzymatic or interaction properties of nsP2 will be revealed using variety of fluorescence-based assays developed in this project. The newly discovered knowledge about structural features of CHIKV nsP2, identification of novel protein surface pockets and binding molecules, and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Aeroponic Inulin and Rubber'.

assistant: **Innovation**

Natural rubber is an essential commodity for the European society. However, the natural rubber market is seriously endangered. Finding an alternative rubber source for the rubber tree is an urgent issue for EU. The EU has funded several projects on alternative rubber crops in the past. Taraxacum koksaghyz (TKS) was identified as the most promising alternative. However, this wild plant is small and does not produce sufficient rubber to be economically profitable. Rubber production can be increased by plant breeding and by improving the growing conditions. In “AIR” I will apply cutting edge technologies of both fields, hosted by KeyGene, a forerunner SME in development of the TKS rubber production chain. I will be using pre-breeding material that KeyGene has developed by interspecific crosses between TKS and large common dandelions. I will make pre-breeding material true-breeding by introgression of apomixis traits. Apomixis is clonal reproduction by seeds and holds great potential for agriculture. KeyGene is a world leader in apomixis research. I will also optimize production of rubber dandelions under artificial growth conditions, such as hydroponical cultivation, variable light spectra by LEDs, salt and mechanical stress. Plants will be digitally phenotyped and gene expression will be monitored. Based on the experiences from the research phase, a 3D farming growth experiment will be conducted. This has never been done before and its economics will be calculated. Being able to produce its own rubber from dandelions the EU will stabilize and lower rubber prizes for European citizens and will produce high quality inulin for food and bioplastics. Good quality jobs will be created in rural and urban areas, and the CO2 emissions will be decreased. The fixation by apomixis in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Advanced high flow rate (process) cell disrupter system including on line analysis of cell broth and energy recovery'.

assistant: **Innovation**

Cell disruption is a critical step in biotechnology processing. Considerable improvements have recently been made in cell disruption techniques at bench level. This research project is intended to take these improvements on to the production scale and to include the cell disruption process as a part of on line analysis of cell broth providing information for fermenter control. Consideration is also to be given to energy recovery as a way of controlling the temperature of the final product. This work is expected to improve cell disruption efficiency at process level, to reduce product research times by guaranteeing scale up with respect to disruption from bench scale to process level and to facilitate improvements in ongoing downstream processes.