RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ARCOMEM: ARchive COmmunities MEMories\n\nFrom Collect-All Archives to Community Memories –   \nLeveraging the Wisdom of the Crowds for Intelligent Preservation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

ARCOMEM is about memory institutions like archives, museums, and libraries in the age of theSocial Web. Memory institutions are more important now than ever: as we face greatereconomic and environmental challenges we need our understanding of the past to help usnavigate to a sustainable future. This is a core function of democracies, but this function facesstiff new challenges in face of the Social Web, and of the radical changes in informationcreation, communication and citizen involvement that currently characterise our informationsociety (e.g., there are now more social network hits than Google searches). Social media arebecoming more and more pervasive in all areas of life. In the UK, for example, it is now notunknown for a government minister to answer a parliamentary question using Twitter, and thismaterial is both ephemeral and highly contextualised, making it increasingly difficult for apolitical archivist to decide what to preserve.This new world challenges the relevance and power of our memory institutions. To answer thesechallenges, ARCOMEM's aim is to:· help transform archives into collective memories that are more tightly integrated withtheir community of users· exploit Social Web and the wisdom of crowds to make Web archiving a more selectiveand meaning-based processTo do this we will provide innovative tools for archivists to help exploit the new media andmake our organisational memories richer and more relevant. We will do this in three ways:· first we will show how social media can help archivists select material for inclusion,providing content appraisal via the social web· second we will show how social media mining can enrich archives, moving towardsstructured preservation around semantic categories· third we will look at social, community and user-ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DISSECTING THE ROLE OF HIF-PROLYL-HYDROXYLASE 2 (PHD2) IN BREAST CANCER METASTASIS – IDENTIFYING NOVEL THERAPEUTIC TARGETS' (PHD2) under Seventh Framework.

assistant: **Objectives**

Breast cancer (BC) is the most frequently diagnosed cancer in women, affecting one in eight women. Despite improved treatment strategies, BC recurrence after initial therapy is still responsible for nearly 500,000 deaths worldwide each year. This is related to the fact that BC cells metastasize very early in the disease course, and often remain unnoticed at the time of diagnosis. Novel therapeutic approaches that block metastasis offer thus great promise. Hypoxia is a key characteristic of solid tumors including breast cancer. Hypoxia inducible factor (HIF) is the main transcription factor involved in the cellular hypoxic response. The oxygen sensor enzymes, HIF-prolyl hydroxylases (PHD1-3) prevent HIF activity under normoxic conditions. Initial results indicate that haplodeficiency of the oxygen sensor HIF-prolyl hydroxylase 2 (PHD2) in tumor and stromal cells reduced metastasis by 80% in a clinically relevant spontaneously arising PyMT BC mouse model. We propose to dissect the molecular mechanisms of how PHD2-blockade inhibits tumor cell dissemination and breast cancer metastasis. Using a multi-disciplinary approach of state-of-the-art conditional and cell type-specific mouse genetics, transplantation assays, in combination with cell biological and molecular analysis in vitro we will determine the effect of PHD2 haplodeficiency on tumor cells as well as on cancer-associated fibroblasts (CAFs). Preliminary data indicate that these stromal cells have reduced invasive properties in the background of PHD2 halpodeficiency compared to wildtype CAFs. Besides promising to yield novel fundamental insights in the role of PHD2 in metastasis, this proposal will also test the clinically relevant question if a induction of global PHD2-silencing at various stages after onset of tumo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Research and information on water purification by means of constructed wetlands (BIOPLATOS) in the Ukraine, supported by studies in Estonia, the Netherlands and Sweden' to be submitted under Fourth Framework.

assistant: **Abstract**

Foreseen ResultsThe current project proposal aims at rebuilding or restoring the experimental bioplatos (and if necessary at constructing new ones). The main objective is to come to ecologically sound, effective water purifications (for waste as well as for drinking water). The programme will capitalize on research achievements, techniques and expertise obtained in the Ukraine in the past as well as in other regions. In this respect, studies conducted in Estonia (at the University of Tartu) on the use of a large variety of constructed wetlands for waste water purification are of special interest. The problems which are encountered in Estonia in connection with water pollutions, particularly the release of toxic compounds by industries, are very similar to those in the Ukraine. The ecological engineering techniques practiced in Estonia include various types of bioplatos. However, lack of funds is also a serious constraint on research in Estonia. Additional support for the proposed research programme will be provided by Finnish institutions (VTT Communities and Infrastructure and the West Finland Regional Environment Centre). This will concern the effect of bioplatos on the nutrient level in the water and the development of mathematical models to forecast hydrological and ecological processes in waterbodies where these ecological engineering techniques are practiced. Furthermore, assistance will be provided by the University of Uppsala (in cooperation with the Uppsala Environmental Protection Office) in Sweden regarding water quality research with emphasis on toxic substances, and the Royal Tropical Institute (KIT) in the Netherlands in connection with aquatic plant management and information systems. Exchange of material and information between all partners will also be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Promotion of European ITS Applications in China through dEdicated conferences'.

assistant: **Innovation**

The PEACE project will organise the following event and its follow-up: The ITS Session of the EU-China Co-operation Forum on Information Society 2002 in Beijing, 16-20 April 2002. It is complementary to the EU-China ITS Conference, which took place in 2001. This latter concentrated on exchange of ITS policies, strategies, standards, and legal and regulation issues and on the identification of potential co-operation areas with greatest mutual interest. The 2002 event however will more address concrete ITS co-operation projects and partnerships between interested European and Chinese organisations. The duration of the project is 18 months.Objectives:The general objectives of the PEACE project are:- to disseminate advanced European ITS technologies to potential users, partners and the general public in China;- to raise the profile of European industry in China;- to encourage a wide application of European ITS technologies in China for mutual interest and to support industry co-operation between EU and China in ITS applications, e.g. co-operation projects, joint ventures.Work description:In order to disseminate European ITS technologies in China and to strengthen the EU-China industry co-operation in the ITS field, PEACE will organise the following event: The ITS Session of the EU-China Co-operation Forum on Information Society 2002 in Beijing, 16 - 20 April 2002. The session will address concrete ITS co-operation projects and partnerships between interested European and Chinese organisations by presenting potential ITS co-operation projects, exhibiting innovative EU ITS systems and organising ITS business meetings. The PEACE project will be carried out in close collaboration with the Ministry of Science and Technology of China (MOST). The duration of the project is 18 mont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'The role of the intracellular peptidases in the immune system and in the cellular metabolism'.

assistant: **Objectives**

MHC class I molecules present peptides from intracellular antigens to the immune system. The peptides are produced by the intracellular proteasome and further trimmed and destroyed by various unrelated peptidases. Only a fraction (0.01%) of these peptides escape peptidase destruction through import into the ER by the peptide transporter TAP before they can bind to resident MHC class I molecules for presentation at the plasma membrane. Since the peptidase activity plays an important role in the selection of peptides for presentation, we propose to study these using microinjection of internally quenched peptides and inhibitors, to measure peptidase activity in living cells. I aim to: 1. Test with a large set of internally quenched peptides the subspecializati on of intracellular peptidases for substrate (peptide) length and sequence. 2. Identify the respective peptidases responsible for the detected subspecializations. Chemical inhibitors and RNAi for TOP, BH and TPPII have been defined and their effects on pep tide destruction will be measured. 3. Test the effect of the peptidases on the petpidome as presented by MHC class I molecules. Peptidases will be inhibited and the resulting peptidome will be assayed by comparative mass spectrometry using differently labelled amino acids. 4. Test whether different cells employ different peptidase activities. The Neefjes lab has indications that dendritic cells change their peptidase activity and I will study this and the effect of various activation stages of these cells in more detail. 5. Combine these findings with the results on manipulation for peptidase activity to determine the effect of peptidase activity on the outcome of MHC class I response in dendritic cells. The experiments should reveal the role of cytosolic peptidase
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Modulation of cortical circuits and predictive neural coding by serotonin' (5HTCircuits), addressing dissemination and exploitation.

assistant: **Impact**

Serotonin (5-HT) is a central neuromodulator and a major target of therapeutic psychoactive drugs, but relatively little is known about how it modulates information processing in neural circuits. The theory of predictive coding postulates that the brain combines raw bottom-up sensory information with top-down information from internal models to make perceptual inferences about the world. We hypothesize, based on preliminary data and prior literature, that a role of 5-HT in this process is to report prediction errors and promote the suppression and weakening of erroneous internal models. We propose that it does this by inhibiting top-down relative to bottom-up cortical information flow. To test this hypothesis, we propose a set of experiments in mice performing olfactory perceptual tasks. Our specific aims are: (1) We will test whether 5-HT neurons encode sensory prediction errors. (2) We will test their causal role in using predictive cues to guide perceptual decisions. (3) We will characterize how 5-HT influences the encoding of sensory information by neuronal populations in the olfactory cortex and identify the underlying circuitry. (4) Finally, we will map the effects of 5-HT across the whole brain and use this information to target further causal manipulations to specific 5-HT projections. We accomplish these aims using state-of-the-art optogenetic, electrophysiological and imaging techniques (including 9.4T small-animal functional magnetic resonance imaging) as well as psychophysical tasks amenable to quantitative analysis and computational theory. Together, these experiments will tackle multiple facets of an important general computational question, bringing to bear an array of cutting-edge technologies to address with unprecedented mechanistic detail how 5-HT imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'HVDC-based grid architectures for reliable and resilient WIdeSprEad hybrid AC/DC transmission systems'.

assistant: **Innovation**

HVDC-Wise project explores concepts and proposes solutions to foster the development of large HVDC based transmission grid infrastructures, able to bring benefits in terms of resilience and reliability to the existing electrical system and capable of integrating the forthcoming large amount of renewable energy. To do so, 5 ambitious specific objectives in line with the HORIZON-CL5-2021-D3-02-08 call expectations were selected:-Develop a complete reliability-&-resilience-oriented planning toolset (metrics, methodology, tools) with appropriate representation of future HVDC-based grid architecture concepts to fulfil TSOs’ resilience and reliability needs.-Propose and compare on generic cases, different HVDC-based grid architecture concepts fulfilling functional requirements relative to TSO’s resilience needs for the widespread AC/DC system.-Validate resilience-oriented planning toolset and the HVDC-based grid architecture concepts on three realistic use cases.-Identify, assess, and model emerging technologies for HVDC-based grid architecture concepts needed for the deployment of widespread AC/DC transmission grids.-Prepare for the adoption and deployment of the proposed solutions by the industry.HVDC-Wise is a multidisciplinary project engaging 14 partners from 11 countries covering the academic (5), TSOs (4) and industrial worlds (5). An implementation plan is presented in the form of 8 work packages, 6 of which are technical in nature. Synergy in communication and dissemination by the several partners and stakeholders will permit to maximize the HVDC-Wise project impact. Solutions to overcome the fundamental technological barriers as well as appropriate deliverables, tasks, milestones, and risks to complete the project objectives in due time are presented.HVDC-Wise propo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of motion-artifact insensitive 3d functional mri techniques for the clinical evaluation of auditory and sensory-motor cortex pathologies' (1994-1998).

assistant: **Concept**

Research objectives and content The applicability of functional MRI techniques to the clinical management of patients with sensory-motor and auditory cortex pathologies will be explored. This will necessitate the implementation of MRI pulse sequences capable of acquiring whole volume images in as short a time as possible, whilst maintaining a high degree of insensitivity to image artifacts produced by bulk patient motion, pulsatile brain motion and fluid flow. To this end, combinations of 3D segmented k-space EPI and FLASH pulse sequences with techniques such as echo-shifting, navigator echo collection and spiral k-space trajectories will be developed in conjunction with suitable activation-task paradigms. Imaging protocols will be developed initially using healthy volunteers. Two clinical roles will be explored: fMRI for surgical planning of patients with tumours of the sensory-motor cortex and fMRI in the management of patients with auditory cortex pathologies, in particular those experiencing tinnitus. Training content (objective, benefit and expected impact) Experience will be gained in the development of advanced MRI pulse sequences on state-of-the-art clinical MR imaging systems, using sophisticated techniques such as multi-shot 3D EPI, navigator echo based motion correction, echo-shifting and spiral k-space trajectories. Experience in activation-task paradigm design, and the implementation of image registration and data analysis software packages will also be acquired. Links with industry / industrial relevance (22) A close research collaboration between the host institution and the manufacturers of the MR imaging systems installed at the host institution (Philips) has been signed with respect to advanced neuroimaging methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Auto Flux - an Autonomous System for Monitoring Air-sea Fluxes Using the Inertial Dissipation Method and Ship Mounted Instrumentation' (1994-1998).

assistant: **Concept**

This proposal addresses Research Area C - Marine Technology, Research Task 2 - Advanced Systems; specifically the adaptation of sensors and samplers for ships of opportunity in order to measure fluxes relevant to global or climatic change. Within the Global Ocean Observing System, these flux data are required for monitoring the marine environment in the open ocean; thus the project is relevant to MAST priority Theme IV, Technological Opportunities" with application to priority Theme III, "Operational Forecasting". The objective is to develop an instrumentation system, "AutoFlux", for routine, unattended use on Voluntary Observing Ships. AutoFlux will automatically produce air-sea flux estimates for the wind stress, buoyancy, heat, and water vapour, using high frequency turbulence measurements. This method minimises the effect of the disturbance caused by the ship and represents a major advance over present, conventional flux estimates. New fast response sensors which will be developed include an improved sonic anemometer, a sonic "thermometer", and a new humidity sensor. Methods for routine estimation of C02 fluxes will be identified and developed for later implementation. Assembling the necessary resources implies European collaboration. The partnership features close collaboration between research organisations and an industrial firm (SME). Together the five scientific partners provide the required range of expertise in turbulence measurement and also the necessary facilities for sensor calibration and field trials. The SME has a successful record in the development, manufacture and international marketing of advanced meteorological sensors and, within the project, will be responsible for the development of the prototype sensors. The project will be managed as a set o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Magnetics and Microhydrodynamics - from guided transport to delivery' in the context of a Horizon 2020 call.

assistant: **Objectives**

This multidisciplinary network entitled: “Magnetics and Microhydrodynamics - from guided transport to delivery” (MaMi) bridges the research fields of fluidics and magnetism, by taking advantage of magnetic forces to control local flows and cargo transport inspired by biomimetic systems. Using magnetic sources, as well as high magnetic susceptibility liquids or nanostructures, devices with unique anti-fouling properties and non-slip boundary conditions can be realized. Our scientific aim is to take advantage of such unique wall-less properties to create new applications of microfluidic technology for life sciences. The network assembles and interdisciplinary team of seven academic and five non-academic partners, exposes all students to industrial environments, and ensures training at the frontiers of two well-established research fields, which are not commonly associated. Over the course of their projects, early stage researchers based in academic institutions will experience working environments in at least 3 different countries. Training a new generation of researchers will bring new cutting-edge knowledge, and will ensure a high potential for industrial applications to promote EU leadership.


**Keywords:** magnetic forces,  cilia,  local flow control