RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel genetic approaches to study breast cancer' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The genetic code of humans and multiple other species has been identified. The critical experiments will be to identify the function of these genes in normal physiology and in diseases such as cancer. Genetic animal models have proven to be extremely valuable to elucidate the essential functions of genes.In particular, the generation of transgenic mice and so-called gene targeted mice has provided novel insights into gene functions and the pathogenesis of disease. Using gene-targeted mice Penninger's group has identified a master gene, RANKL, of bone loss in arthritis and osteoporosis (Nature, 1999; Nature 1999; Cell 2000) and they identified genes that control heart size (Nature 2002;Cell 2002); cell death (Nature 1999 & 2001); cancer (Nature 2000); or pain (Cell 2002).Based on impact factors, his laboratory has been ranked as one of the 10 best laboratories in the world as the only non-US based research group and Prof. Penninger was ranked among the 10 most promising young scientists in the world in all fields of Sciences. After 13 years in North America, the Austrian Academy of Sciences has now made Prof. Penninger and his group an offer to come to Vienna to continue his outstanding work at IMBA, a new Centre of Excellence founded by the Austrian Academy of Sciences.Cancer care will be revolutionized over the next decade by the introduction of novel therapeutics that target the underlying molecular mechanisms of the disease. Prof. Penninger will bring his expertise in functional mouse genomics and biochemistry to Europe to create a new European centre of excellence.A primary goal is to generate a platform for the development and application of functional genomics in order to understand the pathogenesis of malignancies and to provide new animals models to test and dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cancer risks among a irline pilots andcabin crew', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives:To investigate the cancer risk and other causes of mortality of airline pilots and cabin crew in relation to their exposure to occupational risk factors.Brief Description:Aeroplane pilots and cabin crew are exposed to a number of potential occupational risk factors, among them cosmic radiation, engine emissions, electromagnetic fields, disturbances of circadian rhythm, and lifestyle-related factors. The actual radiation dose received by flying personnel varies between 0.2 and 9.1 mSv/year.Current knowledge on health effects of these exposures has remained inconclusive due to limitations of previous studies.The study aims at conducting historical cohort studies in the participating countries and combining the data in a joint analysis. Thus a large cohort of some 22 000 pilots and 47 000 crew members can be formed. Mortality data of this group is to be collected via standard procedures established in the countries. Comparisons with the mortality of the general population will be performed (SMR-analysis). Surrogates of occupational exposure such as time and length of employment and data from measurement of radiation and other exposures will be incorporated into job-exposure matrices and used to perform internal comparisons between exposure groups.The project includes the carrying-out of the national cohort studies according to a common protocol and the joint analysis of the pooled data. Benefits of the study will include increased scientific knowledge about the relationship of occupational risk factors and mortality which can influence decisions on work protection standards of flying personnel.Keywords:Flying personnel, occupational risk factors, low dose radiation, mortality, cancer mortality, cohort study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Nucleic acid nanoparticles for topical ophthalmic drug delivery'.

assistant: **Objectives**

Treatment of eye diseases is severely hindered by the tear fluid and eye lid movement removing the drug. As a consequence, very frequent administration of highly concentrated eye drops is necessary, causing substantial side effects. These side effects occur very often and can range from simple irritations to life threatening anaphylactic shocks in extreme cases. The other shortcoming in treating eye-related diseases is poor compliance, due to frequent dosing.We have developed a drug carrier system for eye drops that have high affinity to the cornea. This allows for a drastically lower concentration of the active compound and less frequent administration. A lower regime results in a better compliance, a higher effectiveness of the drug and less side effects. These nanoparticles can be combined with a wide variety of ophthalmic drugs, including the ones that have been abandoned due to severe side effects. Our approach has been proven during preclinical studies in rat models and even human tissue using two nanoparticle-antibiotic combinations that have shown exceptionally long lasting survival times on the eye of up to four hours.In this project we would like to complete our set of preclinical data regarding efficacy, scope and toxicity of the carrier to achieve commercialization of the drug delivery system.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Resveratrol-induced molecular markers in cancer and progenitor cells proliferation'.

assistant: **Concept**

Many genes that have been shown to cause cancer were originally identified because of their role in embryonic development and in the postnatal control of cell growth and differentiation. The similarities between cancer and development are evident on many levels.  Microscopically, cancerous tissues frequently appear as undifferentiated masses, with some tumor types exhibiting embryonic tissue organization. The increased mobility of cancer cells, leading to local invasion or metastasis, is reminiscent of the migratory behavior of cells during development. We aim to have deeper tumor biology knowledge through gene regulatory network (GRN) models. We consider the characterization of GRNs of tissue specific progenitor/stem cells as a paramount to our understanding of cancerogenesis in colon, lung, and pharynx  (CLP) tumor cells. This research proposal underlies the hypothesis that some cancer cells are closely related to progenitor cell of respective tissue, therefore the tumor drug selection should resemble proper stem/progenitor cell differentiation signaling pathway perturbation. We believe that such tumor-customized drug treatment will be more successful, it will shed light on the comprehension of drug effect overall. Moreover it will highlight new aspects of developmental and cancer biology mechanisms. We will use spheroid in vitro model and moreover we will adopt mouse model to validate in vitro data. The predicted outcome of this research is the identification of novel gene regulatory interactions that will be investigated for their roles in carcinogenetic tissues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'First Regenerative sOlid-STate Barocaloric refrIgeraTor'.

assistant: **Objectives**

Greenhouse gas emissions for refrigeration systems worldwide were in 2019 equivalent to the whole EU emissions. Long-term sustainability requires improvements in energy efficiency, with a huge return on investment obtained from even slight improvements. The mechanocaloric effect, which refers to adiabatic temperature changes induced by stress or pressure, is one of the most promising energy-saving new technology for cooling systems. Mechanocaloric research produced in only 14 years highly performing materials, overcoming electrocaloric and magnetocaloric materials. Furthermore, mechanocaloric materials use non-critical, cheap, abundant and non-toxic elements. Recent papers evidenced colossal barocaloric effects around the Spin CrossOver (SCO) temperatures for some molecular complexes. The FROSTBIT project overall objective is to develop the first operative refrigerator based on a radically new solid-state technology by using barocaloric materials in a regenerative cooling device. In more specific objectives, the project aims to 1) Design sustainable syntheses of compounds for barocaloric applications, exploring synthetic pathways to optimize costs and low environmental impact/low carbon footprint vs. barocaloric performances; 2); Shape SCO materials in order to obtain densified objects with centimetric sizes, study extensively their thermal, mechanical and barocaloric behaviour and explore the optimization of those properties through the preparation of composites ceramics 3) Model, design and build the constituting elements of a barocaloric refrigerator: barocaloric regenerator, thermal and pressure fluid circuits. While the technology could potentially address a wide range of temperature, as an initial step we propose to specifically design and build a refrigerator yie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advancing 2D-Heterostructure Materials for High-Performance Supercapacitors: Integrating SECM and In-Situ Characterization Techniques' (SUPCAP) targeting Horizon Europe.

assistant: **Abstract**

The SUPCAP project aims to develop a new 2D heterostructure electrode material that embeds metal phosphides between graphene oxide sheets for enhanced energy storage applications. This method will address the difficulty of developing conductive, high-capacitive, and stable charge storage materials by combining battery-type and capacitive materials in a layered configuration. We will use a ""Nano-to-Nano"" approach to make all-solid-state symmetric devices using electrophoretic and electrochemical deposition (EPD/ECD) techniques. This will eliminate the need for binders, making the process cheaper and more useful in industry.The research will use in-situ Raman spectroscopy to monitor electrode structural changes in real time throughout charge and discharge cycles. Furthermore, scanning electrochemical microscopy (SECM) will allow for localized deposition of 2D materials by varying local pH and ionic strength. Our goal is to reach a specific capacity of more than 1000 mAhg-1 and a power density of more than 100 kWkg-1. We intend to employ these materials to create 3D-printed micro-supercapacitors for wearable devices, biomedical applications, and airplane backup power systems. This work aims to significantly advance flexible energy storage technology by integrating synthesis, density functional theory (DFT) analysis, and deposition technique optimization to bridge the gap between batteries and supercapacitors.  ""


**Keywords:** 2D -Heterostructure Material, Electrophoretic Deposition (EPD), Electrochemical Deposition (ECD), Scanning Electron Microscopy (SECM), 3D-Printed Microsupercapacitor.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Building a regulatory network for lateral root emergence' in the context of a Seventh Framework call.

assistant: **Objectives**

Cell separation is a critical process for plants. Germinating seedlings emerge from their seed coats, anthers dehisce, fruit ripen, and organs are shed as a result of plant cell separation. To date, several cell wall remodeling enzymes associated with cell separation have been identified, however very little is known about the signals and mechanisms controlling their expression. The host laboratory has recently made major advances in the identification of the signals and molecular mechanisms regulating cell separation during lateral root emergence. The auxin influx transporter LAX3 allows the auxin inducible expression of a set of cell wall remodeling genes in front of the lateral root primordium to promote cell separation. The expression of these genes is dependant on the AUX/IAA proteins SLR1 and SHY2. The main aim of the present project is to study the signals and regulatory network that coordinates plant cell separation employing lateral root emergence as a model. I propose to adopt a Multidisciplinary Integrative Biology based approach which takes advantage of the facilities and expertise available in the host laboratory. Functional genomic, chemical genetic and mathematical modeling approaches will allow to identify new regulatory components and target genes then to build a regulatory network that will be modeled and tested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Product engineering for nutraceuticals with superior quality'.

assistant: **Concept**

Natural products with positive effects on consumer health are defined as nutraceutiacls. The concentration of nutraceutical compounds in natural raw materials is often rather low. The partners will develop methods for manufacturing and marketing of nutraceuticals with superior quality. The products will have unique properties in terms of concentration, release and improved physiological value by removal of unwanted compounds from plant materials with sustainable process technologies. The product engineering focuses not only on new technical solutions but incorporates also the development of marketing strategies, tailor-made for the markets in western and eastern Europe. The products, technologies and knowledge developed in this research program will improve the quality of food and thereby the quality of life and health in Europe. The products also will have a great potential in the pharmaceutical and cosmetic industry.The evaluation of raw material and obtained extracts was established in qualitative and quantitative terms of concentration of valuable nutraceutical compounds and unwanted compounds (alkaloids, pesticides). For this purpose applicable analytical methods were developed and summarised in Standard Operating Procedures, which yielded efficient and reliable analytical results. Thermo-dynamic data on capsaicin, beta carotene as the active principles of chilli peppers were experimentally determined in systems with supercritical CO2. Eight pesticides from four different groups were chosen and phase equilibria investigated in systems with supercritical CO2 thus obtaining solubility data on mentioned compounds. Such data is of great importance in designing extraction/fractionation processes using high pressure techniques with CO2. Phase equilibria data for systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'From Spins to Birds to Traders: Model Adaptation in the Study of Critical Behavior' (MACBeh).

assistant: **Innovation**

Is there a common ground between the behavior of a flock of starlings and the polarization of opinions within human communities? Can we represent traders in a financial market just like spins in a magnet? For years, scientists have conjectured that a certain type of collective behavior ubiquitous in nature adhere to common principles, which can be captured by the physics of criticality. Originally, this idea was largely speculative, but the last three decades have witnessed an increase in the number of concrete approaches to biological and socioeconomic modelling inspired by the physics of criticality. Although plenty of resources are currently spent with the hope that physics can help us prevent unwanted coordinated events, such as population collapse or political radicalization, the foundations for extrapolating the physics of criticality into other sciences remain unclear.MACBeh’s ambition is to tackle this timely challenge by addressing three outstanding questions: (Q1) What is transferred from physics to other sciences in the case of criticality? (Q2) What explains the predictive and explanatory power of some models of criticality outside of physics? (Q3) How can we improve the practice of model building in the study of criticality? We will address these questions from an interdisciplinary perspective, by connecting relevant debates in philosophy of science with a systematic study of existing models of criticality in biology and socioeconomics. The underlying thesis is that models of criticality outside of physics are cases of “model adaptation,’’ a powerful new framework stating that successful models in the new domain are constructed based on universal properties and causal mechanisms borrowed from physics plus the incorporation of domain dependent properties, wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sunflower: Durable  Resistance to Broomrape (Orobanche cumana Wallr.)' (SunPro).

assistant: **Innovation**

Vegetable oils are an essential commodity for the European society. Sunflower oil is one of the main sources of high quality vegetable oil in the European Union and associated states. Production of sunflower oil is seriously endangered by parasitic plants (Orobanche cumana) that highly reduced sunflower yields (up to 80%). Weed control in sunflower is based on chemical herbicide treatments, but the use of these chemicals is under debate due to concerns related to the harmfulness towards consumers, impact on ecosystem and high risk of weeds developing herbicide tolerance. Genetic resistance in sunflower to O. cumana has been identified, but it is not durable due to the emergence of newly evolved races that can overcome the resistance bred into novel varieties. Therefore, an alternative resistance mechanim is urgently needed for sunflower production in the EU. In the here-proposed SunPro (Sunflower Protection against parasitic weeds) program, I will, together with KeyGene as the host institution, apply state-of-the-art molecular breeding technologies to provide such alternative resistance strategy to combat these parasitic weeds. I intend to identify such alternative solution in sunflower using a combination of high-throughput RNA sequencing, computational biology and mutation breeding to provide pre-breeding material that will be utilized by European sunflower breeding companies. If successful, this program will ensure sustainable production of high quality vegetable oil from sunflowers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bioreactive composite scaffold design for improved vascular connexion of tissue-engineered products' in the context of a Sixth Framework call.

assistant: **Objectives**

Engineered tissues today in most cases lack appropriate connexion to the vascular system of the surrounding tissue in body at the implantation site. Hence the tissues suffer from malnutrition and low gas exchange leading to necrosis. To overcome this bottl eneck the strategic objective of this proposal is to develop a novel three-dimensional scaffold structure for improved vascularisation of tissue-engineered products. Application of intelligent biomaterials (bioresorbable stimuli-sensitive polymers) and inc orporation of bioactive substances (e.g. growth factors, monocyte-activating agents) will enhance a structured vascularisation of tissue-engineered constructs by gradually opening inserted microchannels for vessel ingrowth into cell-seeded polymeric scaffo lds. Furthermore, the mechanism of induction of secondary angiogenesis by monocytes will be used to control vascularisation. The signal for the stimulus-sensitive polymer to act (induction of angiogenesis) is intended to be a pH drop associated with malnut rition of cells.The use of angiogenic factors in promoting vascularisation of tissue-engineered constructs so far was performed by a rather isotropic distribution of factors in the scaffolds preventing the build-up of a gradient of bioactive substances for directed cell growth (angiogenesis). In our approach the tubular structure of the microchannels opened up upon activation of stimuli-sensitive filaments will guide cells involved in vascularisation and/or will provide a gradient for directed cell migratio n and growth. The composite scaffold giving rise to evolving vessels is intended to provide the vascular connexion to the surrounding tissue in the course of wound healing. The complex bunch of requirements for a functional vascularisation of tissue-engine er