RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Prostate Cancer Diagnosis, Localisation and Characterisation using Ultrasound'.

assistant: **Innovation**

Prostate cancer (PCa), is a type of cancer with the highest incidence (19%) and second mortality rate (8%) in western men. In 2018 in Europe, 140,000 male patients were newly diagnosed with PCa and over 100,000 patients have died from Prostate cancer. Numbers are rising due to the ageing EU population.The present medical diagnosis procedures are largely based on the execution of multi-biopsy procedure(s) on the patient. Each multi-biopsy procedure is invasive, painful for the patient and incurs significant risk (10%-20%) of adverse health events such as sepsis (8%). Screening programs - comparable to breast cancer screening for woman - are not possible based on biopsy.In recent years, in a few EU countries, an image-based diagnosis method has been added to the PCa diagnosis pathway: Magnetic Resonance Imaging (MRI). A dedicated MRI imaging protocol offers an additional diagnosis tool for detecting and characterising PCa tumour growth. However, MRI based PCa diagnosis has drawbacks: scarce patient access (no public healthcare coverage in multiple EU countries) and long waiting times of 35 days median, increased national healthcare cost and dependent on availability of highly trained radiologist. The gap between the need for image based diagnosis and the availability is rapidly widening. PCaVision is a novel PCa imaging diagnostic method relying on modern ultrasound imaging equipment and advanced signal processing algorithms. Advantages are: equipment costs 96% less and there is not need for a specialised radiologist; the urologist performs the diagnosis. Hence PCaVision makes broad scale access for patients possible, improves PCa healthcare and reduces national healthcare cost. With PCaVision the gap can be closed for the benefit of all EU patients.The result of the Tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Global reanalysis for a forest carbon sink in flux' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Three trillion trees lie behind a carbon sink that has taken up about 30% of humanity’s carbon emissions over recent decades. Yet whether we can continue to rely on this huge natural subsidy is highly uncertain. The sink emerges from systematic perturbations in the dynamics of growth, death and establishment of individual trees. Taken together across the forest, these lead to the net uptake or release of carbon. Both theory and recent observations point towards profound changes in these dynamics of the world’s forests being underway, potentially causing the sink to saturate and decline. But our ability to accurately assess and quantify such on-going changes worldwide is severely limited. The reasons for this are twofold: a lack of standardised measurements of the sink and the dynamics that cause it across the world, and the difficulty of modelling the dynamics of trillions of trees. Tree2Globe solves both of these limitations, using a novel model-data assimilation approach to consistently integrate the dynamics of millions of observations of individual trees collected under disparate protocols worldwide and link together this information in space and time based on physically-consistent principles. The resulting global forest reanalysis system will (a) provide a step-change in capability to make accurate and timely assessment of the rates of tree growth, death and establishment globally and (b) quantify how these combine with the legacies of past land-use and disturbance to explain the size, location and trajectory of the global carbon sink in trees over the period 1990-2027. This will enable us to make a definitive assessment of whether hypothesised changes in forest dynamics and the resulting carbon sink are coming to pass. This unique insight into how the world’s fore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Recovery and enhancement of soil carbon pool (in both organic and inorganic forms) in arid and semi-arid regions, via different agricultural practices', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Soils play an important role in the global carbon cycle. Agricultural lands in semi-arid and arid regions occupy a substantial portion of the world¿s cultivated fields. The potential contribution of these lands towards the global carbon cycle should not be ignored. Soil carbon pool can be divided into the organic and the inorganic carbon forms. With regard to the former, cultivation of soils is known to generate a significant reduction in soil organic carbon (SOC) content.In addition, in semi-arid and arid regions, organic carbon content is a priori low and the climatic conditions are unfavourable for its accumulation in cultivated lands. Carbon sequestration in inorganic forms may prove to be a viable alternative, especially in semi-arid and arid regions, where soil inorganic carbon (SIC) is an important component of the carbon pool. Evaluating SIC sequestration is complicated because of the uncertainty regarding the definition of SIC sequestration. Some consider accumulation of solid carbonate as SIC sequestration, while others consider dissolution of solid carbonate as SIC sequestration. Soils and sub-soils from semi-arid and arid regions commonly contain calcium carbonate (CaCO3). Under cycles of soil wetting and drying, the CaCO3 is subject to dissolution and re-precipitation. Thus, evaluation of SIC sequestration requires monitoring of the changes in the inorganic forms of C in the gas, liquid and solid phases.The overall objective of the proposed study is to develop agricultural management strategies for increasing carbon sequestration (in both organic and inorganic forms) in soils from semi-arid and arid region. This goal will be attained by integrating the results from detailed field measurements and laboratory studies to evaluate the effects of soil properties
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Disruptive Regulatory Technology for Asset Management Industry. FinTech company changes the global Asset Industry forever' (2014-2020).

assistant: **Innovation**

The continued use of a paper-based Contract Lifecycle Process in the Asset Management Industry creates needless inefficiencies, errors, risk and limitations. Asset Managers using state-of-the-art spreadsheets and document assembly tools find their paper chaos transformed into even bigger digital chaos without meaningful improvement of current methods. Furthermore, recent financial regulations (MiFID II in EU, RDR in UK, Dodd-Frank Act in USA) reinforce the need for disruptive technologies to stay competitive in the new investor environment. Metrosoft is set to revolutionize the way the agreements are created and managed in the Asset Management Industry. Fundsphere Terms is a native digital platform that creates, manages and exchanges legal agreements covering Terms of Business between the Sell Side and the Buy Side in a structured database solution. The benefits of such dematerialisation have been demonstrated in the successfully finalised Phase 1 Feasibility Study: Fundsphere Terms disrupts current contract creation by simplifying the workflow and speeding up the process from months to weeks and in the case of amendments from weeks to a single day.The need for Fundsphere Terms was confirmed by key finance firms during the two biggest sectorial conferences in Luxembourg and Hong Kong (ALFI, ITAS) and Key Opinion Leaders who are strong supporters of industry dematerialisation. To fully exploit this EU-based technology, we will drive growth through B2B model and target the top 400 Assets Manager decision-makers and industry influencers. Later growth will be by “snowball effect” (counterparties of Assets Managers). By bringing Fundsphere Terms into the rapidly growing market we estimate to attract min. ≥ 25% of the global Asset Managers, which means volume of approx. +/-20
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A MULTILEVEL ANALYSIS ON THE EFFECTS OF STRESS ON BIOLOGY, EMOTIONS AND BEHAVIOUR THROUGHOUT CHILDHOOD' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The overall objective of the proposed research is to improve our understanding of the interplay between biological, environmental, and social factors that influence the development of harmful behaviours in adolescents. We propose to conduct the first multilevel cohort study of its kind that would combine biological, behavioural, and social data from before birth through adolescence for an entire population birth cohort of adolescents. The program is based in Iceland due to a unique infrastructure for the collection of health and social registry data as well as available access to a whole cohort of adolescents. We will extend our previous work using a multilevel developmental framework to identify both individual and collective level variables to study the independent and interactive effects of biological, environmental, and social determinants of adolescent harmful behaviours, with special emphasis on the influence of stress on substance use, self-inflicted harm, suicidal behaviour, and delinquency. Our retrospective longitudinal database will include existing registry information on maternal, child, and environmental determinants of adolescent harmful behaviours, measured prior to birth, at the time of birth, and during the infant, toddler, preschool, middle-childhood and early adolescent years, for the entire 2000 year birth cohort. We will prospectively measure biomarkers in human saliva and use an existing social survey infrastructure to add to the registry database. We have acquired all necessary ethical and organizational permissions and have carried out a preliminary study that shows registry data compliance of over 90% for all variables we intend to combine. This is a fundamental research project, examining unchartered territory. The results of this project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Liver Electronic Offering Platform with Artificial intelligence-based Devices'.

assistant: **Objectives**

Liver transplantation (LT) is a life-saving procedure for decompensated cirrhosis (DC) and hepato-cellular carcinoma (HCC). Its efficacy is hampered by the risk of death/drop-out on the Wait List (WL). This risk is driven by organ shortage and is mitigated by organ offering schemes. According to a sickest first policy, offering schemes prioritize LT candidates with the highest risk of dying, as assessed by predictive models. To drive allocation, Organ Sharing Organizations (OSOs) use a 20-year-old model, the MELD, predicting mortality in DC but not in HCC. Because of a dramatic increase in % of HCC candidates (40% against 10% in early 20ties), MELD schemes are increasingly inaccurate, with persisting 15 to 30% mortality in countries with low/medium donation rate. This scenario, together with advances in prognosis in DC and HCC candidates and statistics, prompts LT community to look for up-dated algorithms to refine offering schemes. To address this issue, key European LT stakeholders including OSOs, experts in LT, Statisticians, Research Labs and SME joined LEOPARD. Building on an innovative, harmonized OSOs pre-LT dataset and advances in modeling, LEOPARD propose to design and validate 1) an AI-based LEOPARD predictive algorithm outperforming current allocation models by better stratifying patients on the risk of mortality, to be proposed OSOs to drive allocation; 2)  DC & HCC LEOPARD calculators available for professional for assistance in complex decision-making processes; 3) OMICs/radiomics predictive signatures integrated in a prototype 3rd-generation exploratory model. We expect to generate computational tools improving candidates’ outcomes, with more patients transplanted on time. Adoption of these tools should result in harmonization of European heterogeneous pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sensitivity Analysis for Deterministic Controller Design' to be submitted under Seventh Framework.

assistant: **Abstract**

Optimisation-based design of control systems is concerned with determination of control strategies for complex, dynamical systems, to optimise some measures of best performance. It has the potential for applications to a wide range of fields, including aerospace, chemical processing, transportation systems and resource economics.The multi-partner initial training network SADCO aims at: Training young researchers and future scientific leaders in the field of control theory with emphasis on two major themes sensitivity of  optimal strategies to changes in the model specifications, and deterministic controller design; Advancing the theory and developing new numerical methods; Conveying fundamental scientific contributions within European industrial sectors.In order to achieve  these objectives, SADCO establishes a collaborative research and training network of eleven full partners from both the academic and industrial sectors, and gathers participants with expertise in complementary disciplines in mathematics and engineering. The network also offers a complete range of theoretical, practical and complementary training. SADCO will work together with the young researchers to develop and implement effective training plans tailored to each individual requirements. Multi-disciplinary training based on the integrated scientific programme, secondements, regular meetings, active networking,  will ensure  the success of this project.The development of new 'clean' technologies in power,  transportation and other domains is a major opportunity for EU industries. The proposed research programme will help place EU universities in the forefront of Optimal Control, a field of mathematics that supports these technologies. The trainingprogramme, based on institutions covering the principal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Engineering viral vectors for high-throughput CRISPR genetic screens in plants' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Tools based on CRISPR-Cas systems hold great potential both for fundamental plant genetics and precision crop breeding. Unlike traditional mutagenic approaches, CRISPR-Cas systems allow for the simultaneous delivery of thousands of unique guide RNAs, enabling the generation of collections of higher-order mutants for rapid functional screens and the discovery of genetic interactions. However, CRISPR technology suffers from a ‘transformation bottleneck’; relatively few crop genotypes can be transformed and often only a handful of mutant lines can be produced. In virus-induced genome editing (VIGE), plant viruses are engineered to deliver gRNAs into cells. Such a capability is highly attractive for CRISPR knock-out (KO) screens as it could simplify the delivery and generate large populations of mutant lines in a broader range of crop genotypes. However, the application of VIGE for CRISPR KO screens is hampered by the lack of a proper viral-based multiplex gRNA delivery vector. My host lab has pioneered the development of CRISPR KO screens in plants, and in VISCREEN I will combine this knowledge with my expertise on VIGE to scale up CRISPR-Cas-mediated manipulation of plant genomes. The main objectives of my project are: (i) to develop Barley stripe mosaic virus (BSMV) for high-throughput CRISPR screens in wheat and maize; and (ii) to engineer and validate a set of viral vectors for VIGE in soybean. The viral vector-based, high-throughput editing systems developed in VISCREEN will expand CRISPR screens in a wider variety of crops and allow to test fundamental biological questions that are limited by functional redundancy. Overall, this innovative approach will make me a well-trained academic researcher with the capabilities to develop a professional career within the plant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Marine inspired biosilica-filled hydrogels' under Seventh Framework.

assistant: **Concept**

This IOF fellowship merges together two unique concepts toward a common goal, which can have significant benefit to the end users – the patients.  It investigates the potential of a less invasive approach to surgeries through the use of injectable biosilica-filled adhesive hydrogels comprised of a sustainable biosilica phase and a marine inspired adhesive hydrogel.  The IOF fellowship is with Northwestern University and will also open up new avenues of research, with new approaches to established problems, and access to additional equipment and facilities for our group, thus adding value to the work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Electrical actuator with brushless / sensorless permanent magnet synchronous motor for aircraft and submarine application' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content The manufacturing industry, has a need for the development of new procedures for optimisation of the production process. The project concept is to investigate ways by which the current time consuming process improvement loop of simulate-evaluate-modify may be replaced by computational schemes which will complete this task automatically and will identify the global (as opposed to local) optimum for the process-part combination. The project will adopt the success enjoyed in structural optimisation as a starting point and investigate its application to manufacturing processes. The forming processes used to research the concept will be powder forming by initial compaction and also the filling of permanent dies with particular reference to pressure and gravity die casting. These have been chosen due to their generic nature in that the work completed in powder forming will have wider application in other forming processes such as forging and the die filling work will have ramifications for plastic injection moulding techniques. The schedule for this work has been divided into four components. The first focuses on the quantitative definition Of- criteria for optimisation. This will also need to capture process constraints and documenting the precision of industrial data will comprise a major input from the industrial partners in this project. The second component will require some development of best practice analysis procedures for simulating the manufacturing processes and this will use existing schemes which have already been extensively researched by the pertinent team members. The third component and main focus of the project will be to investigate the application of gradient schemes in the optimisation of the manufacturing processes. This will addr