RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Next Generation Immune Checkpoint Inhibitor for Cancer Therapy'.

assistant: **Objectives**

Immune checkpoint inhibitors (ICIs) for cancer therapy have revolutionized the treatment of several cancers. These ICIs are made from monoclonal antibodies that antagonize inhibitory signals via cytotoxic T-lymphocyte- associated antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1) that block the tumoricidal activity of T cells. Although these ICIs have improved the overall survival of cancer patients such as cutaneous melanoma patients, only one third of patients has remained progression-free 5 years after initiating ICI therapy. This low efficacy is largely due to (1) the presence of immune suppressive regulatory T cells (Treg) within tumor microenvironment (TME) (2) the lack of efficacy of tumor penetration and retention. To improve the current ICI, this project RenTenTion aims to develop a next generation ICIs with smaller molecule so called single domain antibody (sdAb), give rise to enhanced tumor penetration. Targeting against a new immune checkpoint molecule 41-BB that highly expressed by intratumoral Treg, this next generation sdAb based ICI will inhibit tumor promoting immune cells Treg, while stimulate tumor rejecting immune cells such as effector T cells in tumors. Additionally, this project will couple the sdAb with collagen binding domain receptor so called leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) that bind to collagen in the tumor, therefore sustain tumor retention. This project “ReTenTion” will fill a gap for a strong need for new ICI molecules capable of addressing immunosuppressive in TME, yet smaller than conventional ICIs, boosting passive delivery.


**Keywords:** Immune Checkpoint Inhibitors, Single Domain Antibody
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering different layers of regulation of FLOWERING LOCUS D, a bZIP transcription factor that promotes flowering of Arabidopsis' (2014-2020).

assistant: **Concept**

Floral transition denotes the initiation of plant reproduction. Several genetic pathways regulate this important transition and many of them converge on the regulation of FLOWERING LOCUS T (FT), the systemic flowering signal that moves from leaves to the shoot apex. FT reprograms transcription at the shoot apex by contributing to Florigen Activation Complex (FAC). A central component of this complex is the bZIP transcription factor FLOWERING LOCUS D (FD), which is responsible for DNA binding and gene specific regulation by the complex. I will employ single-cell RNA sequencing to capture the transient cell state where the FAC complex and two different target genes, APETALA1 and SOC1, are coexpressed. Defining the transcriptomic network of FD at the single-cell level will provide a deeper understanding of this dynamic process. Phosphorylation of a threonine residue in the SAP motif at the C terminus of FD is a key step in formation of the complex. Phosphomimetic or non-phosphorylatable FD SAP motif versions have opposite effects on FD function, being able or not, respectively, to complement the late flowering phenotype of fd-3. I will investigate whether SAP motif phosphorylation affects FD protein stability or impairs its protein-protein interactions using confocal microscopy and protein mass spectrometry. In addition, other bZIPs closely related to FD are phosphorylated at other sites, but no analysis of FD phosphorylation sites other than the SAP motif has been presented. I will map post-translational modifications of FD, which may reveal new regulatory steps in controlling FD activity. I will explore the ability of FD to form protein complexes with other transcription factors by employing yeast-two hybrid, protein pull-downs and interaction studies using immunoprecipi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Memory in biological regulatory circuits' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The emergence of intelligence –the ability to remember and analyze data to make decisions– was a milestone in evolution. Intelligence and memory are usually associated with plastic neuronal connections in higher organisms. However, new discoveries hint that a rudimentary form of intelligence is rooted in networks that regulate gene expression in a wide range of organisms, including bacteria and yeasts. Specifically, we and others have shown that microbes show plastic behavioral responses to past experiences, such as previously available nutrients or stresses. This implies that information about the past is somehow retained and passed to next generations, where it influences cellular regulation.The goal of this project is to use a simple eukaryotic regulatory circuit as a model to obtain a comprehensive picture of the different genes and molecular mechanisms underlying history-dependence (hysteresis) in cellular regulation. Specifically, we will study maltose (MAL) regulation in budding yeast, because this signaling pathway serves as a model for gene regulation circuits in other organisms, including humans. We will use a combination of genetic screens, live-cell microscopy in custom-built microfluidic devices, and mathematical modeling to pursue four aims:1. To provide a comprehensive quantitative analysis of hysteresis in MAL regulation 2. To unravel the molecular mechanisms contributing to hysteresis 3. To unravel the epigenetic mechanisms allowing hysteresis to extend over several generations4. To characterize the ecological relevance of hysteresisThis project will establish an innovative model for hysteresis and generate a genome-wide, systems-level view of how past influences can be stored in regulatory cascades to influence cellular decision-making. The results wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Type 2 diabetes and obesity among sub-Saharan African native and migrant populations: dissection of environment and endogenous predisposition' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Migration from Sub-Saharan Africa (SSA) to Europe is increasing. The limited evidence suggests that the risk of type 2 diabetes (T2D) and obesity among SSA migrants is higher than among their SSA peers living in Africa and European host populations. The reasons for these observations are only poorly understood, but may involve migration-related changes in lifestyle, genetic predisposition as well as pe¬culiarities in perceptions and practises. Contrasting the increasing number of African migrants in Europe, the health status and needs of these populations remain largely unexamined, and have only insufficiently been integrated into national plans, policies and strategies. Implementation of tailored intervention programmes among migrants implic¬itly requires the identification and the disentanglement of environmental, lifestyle and genetic factors modifying T2D and obesity risk.The RODAM project addresses these fundamental health issues among a homogeneous, and one of the largest SSA migrant groups in Europe (i.e. Ghanaians). RODAM thus aims to contribute to the understanding of the complex interplay between environment, lifestyle, (epi)genetic as well as social factors in T2D and obesity among SSA immigrants, and to identify specific risk factors to guide intervention and prevention and to provide a basis for improving diagnosis and treatment.In a multi-centre study, 6,250 Ghanaians aged >25 years will be re¬cruited in rural and urban Ghana, Germany, the Netherlands, and the UK. The differences in prevalence rates within Ghana on the one hand, and three European countries on the other, will allow us to unravel environmental, lifestyle and (epi)genetic as well as social factors in relation to T2D and obesity.The proposed study will generate relevant results that will ulti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improved sustainability of agro-food chains in central America: a techno-managerial approach' under Fifth Framework.

assistant: **Concept**

The sustainability of the linkages between agro-food production in developing countries, and final consumption in developed countries has been continuously under pressure. Unequal income distribution within the commodity chain, environmental and health risks, as well as mismatches with consumers preferences have created an unstable setting. The commodities to be investigated are important for the socio-economic development of Central America and may count with considerable consumers demand in the EU. The proposal develops technology evaluation tools to make EU-CA agro-food systems more sustainable from environmental, food safety and socio-economic perspectives. The results will be useful for producers (to enhance added value, and improve living and working conditions), the EU consumer (safe and stable supply of good quality products) and the environment (less pollution, saving natural resources).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular-Physical Basis of Cell-Biomaterial Mechanical Coupling' (CELLMECH) under Seventh Framework.

assistant: **Objectives**

I seek to understand the molecular origin of cell mechanosensing - the ability of biological cells to sense and respond to the mechanical properties of their environment. Moreover, I want to explore the possibility that propagation of mechanical deformation within soft biomaterials can act as a communication route between neighboring cells. A long term goal is to guide injured axons to establish reconnection with the proper target by directing the axon towards the mechanical deformations generated by the target cell. ‘Cell mechanosensing’ raises some basic science questions, part of which can only be solved by an interdisciplinary-multi-scale approach, combining concepts from macroscopic approaches -  such as elasticity theory and rheology - with a molecular point of view, taking into account the intricate interplay of chemical and physical processes. We will use a unique combination of high resolution optical microscopy, single molecule imaging, magnetic tweezers, biomaterial design and characterization, numerical algorithms and theoretical modeling. In particular, our aims include: 1.Characterization of the force generated by neuronal growth cone and its frequency, before and following injury.2.Developing new engineered protein biomaterials with mechano-sensitive properties and a well defined dynamic viscoelastic profile which are able to support neuronal cell growth. These include biomaterials which: a) Change their fluorescence properties in response to small material deformations in the nanometer range. b) Efficiently propagate and amplify growth-cone-generated mechanical deformations to allow for cell-cell communication. An essential part of this project is studying the dependence of the viscoelastic spectrum of the network on the mechanical properties of the sing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The relationship between technological strategies of multinational companies and national systems of innovation. consequences for national and european s&t policies' (1998-2002).

assistant: **Innovation**

Firstly, the creation of a network is proposed to help national and European institutions to discuss, elaborate and promote new actions oriented to reduce some of the negative impacts the new international framework can bring and to upgrade the possibilities of European firms for using adequately the new opportunities supplied by the new technological scenario. Secondly, it is created to encourage new research activities for achieving a better understanding of such a complex issue as far as current knowledge is clearly insufficient, as recent reports demonstrate (ETAN Working Paper, OECD reports, etc).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'enabling SMEs to develop AI and DATA solutions through support of a Community of Practice and low-TRL and high-TRL playgrounds'.

assistant: **Innovation**

AID4SME will facilitate SMEs in developing combined AI and data solutions for large scale resource optimisation challenges for industries that have significant impact on the objectives of the Green Deal. Minimum 20 SMEs, selected through 2 open calls, will receive FSTP to develop these solutions with the support of a Community of Practice (COP). The ambition is to create a COP that will continue after the project lifetime.AID4SME brings together 9 technology blocks and low-TRL playgrounds from 4 scientific partners, to educate and support the SMEs. Additionally, 4 large industry partners (from automotive, whitegoods, battery and energy sector) provide real-life large scale resource optimization challenges that require combined AI and data solutions, and high-TRL playgrounds to integrate and demonstrate the solutions.AID4SME offers an open platform that is flexible to bring in challenges from outside the consortium.AID4SME provides the infrastructure and learning environment that enable the SMEs to solve the challenges, demonstrate solutions and grow into impactful enterprises. The technology blocks cover a wide area of AI & data technologies for the full cycle of data collection, creation of insights, decision support and automation. These technologies have the potential to have significant impact on the Green Transition and boost EU competitiveness for industries. AID4SME will collaborate with the AI-on-Demand platform to enrich its repository with the AID4SME tools and framework, while it is open to deploy the tools/frameworks already available on the AI-on-Demand platform for new use cases. AID4SME will assess the impact of the developed technologies on Green Deal objectives and on social and human aspects. AID4SME brings along partners who are experienced in re-skil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enhanced X(cross)-disciplinary Community-driven Imaging Technologies for Earth and Environmental material research' (EXCITE2), addressing dissemination and exploitation.

assistant: **Impact**

The EXCITE² Network is revolutionizing Earth and environmental material science research by consolidating a critical mass of 18 research facilities in 12 European and associated partner countries into a unified infrastructure and providing transnational access to advanced imaging technologies. This enables scientists to decipher complex processes within Earth materials at scales from nanometres to hundreds of centimetres, gaining unparalleled insight into the chemical and physical processes that govern, among others, environmental toxicity and its impact on human health, critical metal extraction for renewable energies, and the utilisation of Earth materials as long-term storage for climate-altering gases. The consortium fosters knowledge-sharing and talent attraction, bolstering the problem-solving capacity of the European Research Area. Moreover, EXCITE² is driving interdisciplinary collaboration and cross-fertilisation across academic institutions, scientific disciplines, and industry, propelling Europe towards a sustainable future. The initiative offers dedicated training programmes to a new generation of researchers within the European open science landscape, paired with access to world-class imaging facilities and expertise for problem-solving research and innovation. EXCITE² is introducing innovative service developments, such as artificial intelligence and leading-edge imaging experiments, to increase the user's problem-solving capacity. In addition, the consortium is implementing customised project valorisation strategies to maximize the impact of research outcomes in academia, society, and the economy. Citizen science projects allow the public to participate directly within the EXCITE² Network, contributing to solving EU challenges. As such, EXCITE² is paving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High Precision Process Chains for the Mass Production of Functional Structured Surfaces' (ProSurf).

assistant: **Concept**

The ProSurf project aims to enhance the surface functionalities of six demonstrator parts by using a wide range of high precision manufacturing technologies, such as diamond machining techniques, enabling the mass production of cost effective, structured parts with accurate replication technolo-gies, like micro injection moulding. By implementing these technologies to manufacture a variety of benefiting functionalities, it is critical to assess the parts quality in a safe and fast manner. Therefore, the ProSurf project incorporates the development of robust in-process metrology as well as the derivation of the surfaces’ functions to three dimensional parameters for a fast measurement of functional relevant surface characteristics and specific function testing of the produced demonstrators. Due to the spectrum of surface functionalities linked to the part demonstrators and their varied application fields that range from optical to medical, ProSurf makes possible to reach a high impact on several areas of the society by, e.g. increasing the safety of medical procedures and the performance of moulds for ceramic injection moulding as well as cleaning rolls for electronic parts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'String compactifications, their low energy effective field theories and applications to physics' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Recent advances in string phenomenology have produced hundreds of explicit string compactifications whose low energy particle spectra correspond to the supersymmetric standard model and no chiral exotics.  This project concerns the low energy effective field theory (LEEFT) of such string compactifications, which is essential in order to go beyond the particle spectra towards fully realistic string models.  In particular, with the LEEFT it will be possible to address fundamental dynamical problems - like the stabilization of moduli and supersymmetric breaking, the decoupling of vector-like exotics, realistic Yukawa couplings and cosmology - in explicit models.The project's main focus will be heterotic orbifold compactifications, which enjoy both potentially realistic properties and high computability.  New techniques will be developed to compute terms in the LEEFT, and these tools will be used to derive phenomenologically important contributions to both the superpotential and Kaehler potential.  The project will also quantify some of the relations between different classes of promising string compactifications, including heterotic orbifolds, heterotic Calabi-Yaus, heterotic free-fermionic formulation, and F-theory.  Finally, it will use the knowledge developed to attack the long-standing fundamental problems of moduli stabilization, decoupling of exotics and dark energy in explicit string constructions.