RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sugars maketh the brain: investigating the role of neuronal glycocalyx in shaping the architecture of emerging circuits' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Neuronal glycocalyx has been recently recognized as an active agent that contributes to neuronal synapse formation, neuron excitability as well as neuron-autonomous and microglia-dependent brain network remodelling. In particular, the glycan-terminating sialic acids, which often dominate the ends of the chains of glycoproteins and glycolipids on neuronal surface, are required for appropriate brain development and function. Interestingly, almost a fifth of sialic acid biology genes have human-specific changes and aberrant neuronal sialylation and desialylation are implicated in different neurodevelopmental and neuropsychiatric conditions. Thus, I hypothesize than neuronal glycocalyx and specifically its component sialic acid in particular have a critical role in the formation of unique human brain. Despite its recognized importance, there is still a lack of mechanistic understanding filling the knowledge gap how synapses are shaped by the dynamics of the glycocalyx. Therefore, here I propose to merge my expertise in biochemistry and neuroscience to tackle this challenging area of research to further our knowledge of brain sialome through evolutionary approach. We will use in vitro, ex vivo and in vivo models from humans, non-human primates and mouse that can be modified at genetic level for selective labelling and modification of neuronal cells and will combine it with advanced microscopy techniques as well as synaptic-level molecular analysis. We will demonstrate how the glycocalyx and sialic acid act as a defining factor for neural circuitry formation and refinement in developing brain, in particular through the interaction of neurons and their synapses with brain immune cells – microglia. Our results will advance our understanding of fundamental contribution of the gl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification and development of novel colorectal cancer biomarkers via state-of-the-art liquid biopsy approaches', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The ColoMARK network integrates 17 teams with multidisciplinary expertise (omics, epidemiology, microbiome, circulating tumour DNA, bioinformatics, assay development, circulating RNAs, circulating tumour cells, tumour profiling, clinics) that will take advantage of the assets conferred by novel liquid biopsy strategies to provide complementary and comprehensive know-how on the features required to successfully fulfil the objectives of ColoMARK: 1) to foster a next generation of scientists that can address the challenges of colorectal cancer biomarker development. The network is enforced by pre-existing collaborations from COST Action TransColonCan, and enhanced by the participation of non-academic entities, who will play an essential role in the cross-sectoral and transversal training of the researchers. It is our purpose to provide a personalised training programme that builds on the knowledge offered by the participants to produce future cross-sectoral leadership and a sustainable initiative of excellent research that enhances the competitiveness of European researchers; 2) to achieve maximum impact by appropriate dissemination, patient and public engagement, and results exploitation, activities that will be embedded in the training of the researchers. Given the promising perspectives of liquid biopsy approaches for the future of cancer prevention and management, ColoMARK will constitute an opportunity to reach outstanding scientific, technological and societal impact in a field highly relevant to Horizon Europe´s priorities in cancer, therefore enhancing European competitiveness in R&I; 3) to advance in colorectal cancer understanding by producing outstanding, synergistic research. As the main scientific aim of ColoMARK, ten tailored ground-breaking research projects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Rashba Effect-induced non-VOLatile ferroelectric control of spin-orbit coupling in Two-dimensional materials' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The surge of electronic devices in our everyday lives poses severe challenges to the sustainability of our societies. Spintronics stands at the forefront of solutions considered today by leading industrial actors to drastically improve information and communications systems' scalability and power efficiency. In this field, most of the efforts focus on information storage based on ferromagnets (FM), readout via spin-charge interconversion (SCI) phenomena, i.e. the conversion of a spin polarisation into a detectable electrical signal, or vice-versa. However, improvements in SCI efficiency are still necessary and solutions for the electrical writing of FM still need to be more efficient and reliable. Ferroelectrics (FE), which naturally break inversion symmetry, may allow an efficient SCI when interfaced with other materials. Since FE also carry information (their electric polarisation) switchable at ultra-low power, they are ideal candidates to replace FM as the new core elements of spintronics. So far, only a few reports demonstrated the FE control of SCI at oxide interfaces or in bulk semiconductors. Due to their richness and 2D nature, van der Waals (vdW) materials and notably graphene play an increasingly important role in spintronics research, and vdW FE could be a game changer for the field, although they are still under-investigated. REVOLT aims to study these novel FE and to achieve the non-volatile electric control of SCI in graphene proximitized with FE. Structural, electrical, and magnetotransport characterisations will be performed on atomically sharp FE/graphene stacks patterned with advanced nano-lithography techniques for which the host institution is expert. Based on these efforts, REVOLT will shed new light on fundamental physics phenomena and evaluate th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mechanics of refractory materials at high-temperature for advanced industrial technologies' (HOTBRICKS).

assistant: **Innovation**

HOTBRICKS project is principally aimed to exchange know-how and experience in the modern and challenging field of Nonlinear Solid Mechanics via staff secondment, through the design of thermal shock resistant elements in use for liquid steel technologies, in a close and synergic collaboration between a research academic group (UNITN) specialized in the modelling of nonlinear behaviour of materials and a creative industry (VESUVIUS), leader in the production of refractories for steel, glass and foundry industries and committed to safety and sustainable development. The goal will be reached by :i) advances in the design of refractory pieces and machines; ii) development of innovative technologies for handling molten materials (steel, glass or other). The novel technologies will improve problem identification and enhance successful design, with an increase of safety factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bacterial Abiotic Cellular Stress and Survival Improvement Network' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

BACSIN is a 16-member consortium with the main focus to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of environmental pollution. Current application of bacteria in the environment is hindered by the lack of knowledge on the effects of stresses on cellular activity, most importantly abiotic stresses prevailing on site (e.g., desiccation or nutrient starvation), stresses as a result of pollution itself (e.g., toxicity), and those during strain preparation and formulation. BACSIN proposes four iterative poles of research and technology to overcome this hindrance for subsequent improved microbial usage. The 1st pole will investigate genome-wide catabolic and stress expression in a set of different pollutant degrading bacteria (the ‘BACSINs’). Key cellular factors and regulatory networks determining the interplay between stress-survival and pollutant catabolism will be unveiled, and faithful predictive models for cell behaviour produced. The 2nd pole will study stress resistance, survival and activity of BACSINs in real polluted environments, via microcosms and in situ ‘traps’, plant roots and leaves, while accentuating possible effects on native communities. The 3d pole will focus on the original microbial communities at contaminated sites, to discover and exploit more optimal stress and survival resistance among resident pollutant-degrading bacteria. We will develop molecular diagnostics tools to screen contaminated sites for catabolic and stress parameters, and decide whether BACSIN complementation should be considered. Promising isolates of resident bacteria will be studied as new BACSINs, to show the usefulness of the ‘diagnosis-isolation-reintroduction’ approach for enhancing pollutant biodegradation rates. Fina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Energy balancing and resilience solutions to unlock the flexibility and increase market options for distribution grid' (2014-2020).

assistant: **Concept**

The ebalance+ project applies to the ‘Flexibility and retail market options for the distribution grid’ by addressing flexibility solutions, smart-grids technologies to increase the distribution grid resilience and defining and testing market mechanisms and tools incentivising the energy flexibility. In this context, the ebalance+ project aims to increase energy flexibility of distribution grids, predict available flexibility, increase distribution grid resilience and design and test new ancillary models to promote new markets based on energy flexibility. These objectives allow unlocking the energy flexibility market in distribution grids to support energy prosumers and electric operators.The ebalance+ proposal is an ICT platform that assure the integration and interoperability at any electricity domain, providing an effective market framework where electric operators and stakeholders benefit with new business models. The system is composed of units that implements algorithms to forecast and manage the available flexibility to incentivise demand response programmes and increase the distribution grid capacity to avoid congestions and advise optimization strategies. Besides, it allows integrating the flexibility solutions (developed and tested in the project): electric storage, V2G systems, SiC power inverters, power to heat, control of CHP and management of building devices with IoT-based systems. Smart-gird automation and control solutions will be integrated to enhance the grid observability and use the available flexibility to increase the resilience under critical events.The consortium is composed of 15 entities from 8 EU countries, which the participation of research centres, SME and industry. The solutions are tested in 4 real-life pilots (Spain, Italy, France and De
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design of an Interoperable European federated Simulation network for critical InfraStructures' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

DIESIS proposes to establish the basis for a European modelling and simulation e-Infrastructure based upon open standards to foster and support research on all aspects of critical infrastructures with a specific focus on their protection. DIESIS will perform a thorough conceptual design study in order to prepare the establishment of such a research e-Infrastructure.<br/>In particular, DIESIS will: a) analyse in detail the requirements for the research e-Infrastructure coming from researchers, industrial stakeholders, decision makers and governmental organisations; b) develop an extensible ontology and communication protocols in order to define a standard for interoperable simulations in the field of critical infrastructure protection; c) provide concepts enabling interoperability among heterogeneous and distributed modelling and simulation technologies; d) design an ICT architecture for a distributed European e-Infrastructure on top of existing GRID approaches in order to support federated, interoperable simulations and research on critical infrastructure protection; e) implement a prototype of such an infrastructure as a proof of concept; f) assess the feasibility (scientific, technical, and financial) and the potential impact (scientific and technical) of such an e-Infrastructure.<br/>While the main focus of the project is on research in the critical infrastructure domain the developed concepts, protocols and technologies will be applicable much more broadly. In principle, these should be applicable to all kinds of research where federated simulation is useful.<br/>By providing the design and the evaluation of the feasibility DIESIS is the first step towards a European e-Infrastructure for research in the important and emerging field of critical infrastructure protect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DEMOnstration for Tidal Industry DErisking' (DEMOTIDE).

assistant: **Innovation**

The European tidal industry is at a critical stage. Successful demonstration of small-scale tidal arrays with lessons learnt for future large-scale projects is widely acknowledged as a key way to de-risk and kick-start the tidal energy industry. The DEMOTIDE project will design, build and operate a 4 x 1.5MW (6MW) turbine array at the MeyGen Phase 1B site, Pentland Firth, Scotland. The potential for build-out on the MeyGen site to 400 MW installed capacity, based on the available local high flow tidal resource, make this a site ripe for commercial exploitation. The DEMOTIDE consortium unites strong players with each of the required competencies to deliver this array. Leading technology supplier Marine Current Turbines (an Atlantis company) can rely on experience gained from operating its SeaGen tidal turbine system for several years. The participation of both MCT and Atlantis technology development teams is crucial to deliver robust, efficient turbines, fully specified to perform in challenging tidal site conditions. Effective installation plans are only possible through early involvement of an experienced marine contractor. DEME, comprising DEME Blue Energy and GeoSea, is a world leader in marine operations and owns a versatile fleet (jack-up platforms, DP, heavy-lift, barges, etc.) which can be applied to the tidal market. DEME subsidiary GeoSea will bring extensive offshore wind energy installation experience to the table. The combined involvement of DEME Blue Energy, Atlantis Resources, and French partner INNOSEA provides a strong route to exploitation of the results of DEMOTIDE across a portfolio of commercial tidal energy projects throughout Europe and abroad. Finally, local content and dissemination of the project results is ensured through involvement of Queen’s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'IMPROVE THE TEXTILE PRETREATMENT PROCESS' (1994-1998).

assistant: **Innovation**

Aims: to improve the textile pretreatment process. State of the art is a discontinuous process in at least 4 steps. A continuous process with only 2 steps saving energy, water and chemicals shall replace the conventional process.Innovative aspects:1. in a new apparatus simultaneous application of energy and chemicals will be possible combined with temperature shock treatment.2. exact dosage of chemicals corresponding to textile threwput3. intensified washing by using special stripping cylinders. Realistic goals: saving electrical energy 70%, thermal energy 40%, water 40%, chemicals > 50%.L%
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Energy Efficiency and Electrification Technologies for Heat Flow Optimization in Process Industries', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Industrial process heating accounts for 16 % of total final energy demand and 13 % of the greenhouse gas emissions in the EU. Decarbonizing industrial process heating through electrification and increased energy efficiency is a key measure for reaching the climate targets in 2030, reducing the dependency on fossil fuels, strengthening the exploitation of local renewable energy sources and increasing the competitiveness of the European industry. While there are highly efficient technologies, such as industrial heat pumps, available for temperatures below 150 °C, there is a clear demand for novel technologies for processes with heat demands at higher temperatures. EEETHOS will fill this technology gap by developing key-enabling technologies for energy efficient, flexible and decarbonized process heating, and demonstrating them in five installations at industrial end-users at a TRL of 7. The technologies comprise among others, two high-temperature heat pump solutions for steam supply at up to 200 °C, a reversed Brayton heat pump with supply temperatures up to 300 °C, an innovative technology for heat pump-based drying and heating of minerals, a highly integrated steam compression-based solution for superheated steam drying and a heat capturing device for radiative waste heat recovery. These key-enabling technologies will be demonstrated in 5 demonstrators at industrial end-users representing EUs energy intensive process industries: asphalt, ceramics, pulp & paper, bricks and steel. These technologies are scalable for plant-wide implementation, allow a complete decarbonization at energy savings between 43 % to 86 %, based on local renewable energy sources. The development, implementation, operation and scaling of these technologies is optimized by use of digital twin-based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synaptic engrams in hippocampal CA3 memory circuits' (CA3-SYNGRAM), addressing dissemination and exploitation.

assistant: **Impact**

A fundamental question in neuroscience is how information in brain circuits is stored and retrieved. However, the physical and chemical changes underlying the formation of memories, or “engrams”, are largely elusive. Although recent work identified engram cells, the nanoscopic changes at synapses during engram formation remain unclear. New experimental techniques allow us to probe the subcellular and synaptic components of the engram: functional analysis by multicellular electrophysiology, structural analysis by superresolution light and electron microscopy, and optical recording and stimulation techniques in vivo. Here, we propose to combine these techniques to reveal engrams in the hippocampal CA3 network. This circuit is ideally suited to identify engrams, as it plays a critical role in learning and memory, forms the largest recurrent network throughout the brain, and receives powerful input from hippocampal granule cells, previously defined as engram cells. The project has two main goals. First, we want to identify the physical and chemical changes in the CA3 network during engram formation, especially changes in synaptic transmission and network connectivity. Thus, we will be able to rigorously test cellular, synaptic, and connectomic hypotheses of the engram. Second, we want to probe the rules of synaptic engram storage (“engraphy“), the mechanisms of engram retrieval (“ecphory“), and the behavioral content of the engrams. Hence, we will be able to enrich the classical engram concept with quantitative data on how synaptic engrams are efficiently stored and reliably retrieved. Taken together, the expected results will lead to a substantial increase in our understanding of engrams, advancing it from the cellular to the synaptic level. The proposed experiments will a