RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Collaborative Oncological Gene-environment Study' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,000 individuals in the COGS project. We will use detailed knowledge of the architecture of genetic susceptibility and interactions with environmental/lifestyle factors which will result in much more accurate individual risk prediction and improved intervention strategies.   We are taking advantage of a unique possibility by incorporating seven existing consortia into one large project – COGS. Members of these consortia have collaborated successfully over the past years and results have been presented in world leading scientific journals such as Nature, Nature Genetics and Journal of the National Cancer Institute. These papers reflect that collaboration has been ongoing and that is has so far been very successful.  We will also build on an existing European Commission project, TRANSBIG, thus adding value to already spent money.  Results generated through COGS will lead to an improved understanding of the biological processes that underlie carcinogenesis, that in turn could guide new therapeutic strategies. Results will also lead to the development of new tests for risk prediction for breast, ovarian and prostate cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Zilina innovation policy' under Sixth Framework.

assistant: **Concept**

An overall objective of ZIP (Zilina Innovation Policy) project is, through the RIS process, to create an enabling environment for research & development, innovation and business in the Zilina region. Key objective of ZIP is to set up basis for regional institutional structures for innovation support, based on collaborative networks between existing institutions and organisations, and to implement a strategic innovation framework that will enable existing firms to introduce more innovation at all levels and create a positive culture for new entrepreneurs. One success factor to achieve this will be to establish autonomous and stable networks of key-persons from science, administration and industry (triple helix) within the region, as well as on an ?over-re gional? level, in neighbour and foreign countries. This objective fully responds to the Technical content of the ?Research and Innovation? Work Programme: ?Encouraging regional innovation policies and trans-regional cooperation?. Specific project?s objecti ves include more high performing companies in the Zilina region, easier access to knowledge and expertise as well as improved support for companies. They reflect the scientific, technical, wider societal and policy objectives of the Research and Innovation activity area. Beyond the national aspect, they take into consideration the European scientific, technical, and wider societal and policy objectives of the Research and Innovation activity area, by integrating the objectives of the 6th Framework Programme and the Specific Programme ?Structuring the European Research Area?. ZIP project consortium involves four partners: University of Zilina - representing the Self-Governing Region of Zilina, Region of Lower Austria - European region of excellence, Region Sö dermanlan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New single-molecule techniques and their application in the study of DNA break repair', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Unrepaired DNA breaks can lead to genomic instability or cell death. They occur frequently during normal cellular metabolism and are caused, for example, by the collapse or stalling of the replication fork in response to DNA damage. Proper DNA-end processing and handling are essential for the survival of the cell and prevention of carcinogenesis. Cells possess robust mechanisms to repair DNA breaks. One such DNA repair mechanism is homologous recombination where the sister chromatid is used as a template for the faithful repair of the DNA break. In Bacteria, this pathway is initiated when a DNA end is processed to a 3-ssDNA overhang terminated at a recombination hotspot (Chi) sequence. This is a substrate for formation of a RecA nucleoprotein filament that catalyses strand exchange to promote repair. Recent data implicate the AddAB helicase-nuclease and the SMC (Structural Maintenance of Chromosomes) complex in the DNA break processing mechanism of the model organism Bacillus subtilis. Interaction between these machines provides a molecular link between DNA dynamics and the initiation of DNA break processing that may co-ordinate replication fork collapse and DNA repair. Single-molecule manipulation and imaging techniques offer huge potential to investigate DNA break repair reactions in completely new ways, providing information that is inaccessible to conventional ensemble experiments. The aim of this project is two-fold: firstly, to develop novel biophysical instruments for fast Atomic Force Microscopy imaging in liquid and a combined Optical and Magnetic Tweezers setup; and secondly, to monitor and characterize the real-time dynamics of these DNA-repair processes using these new and complementary biophysical approaches. Single-molecule investigation will be supported
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neurobiology of Stress in Health and Disease' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Scope: This Summerschool focuses on the molecular and cellular basis of neuropsychiatric stress system disorders including depressive illness, anxiety and aggressive states, post-traumatic stress disorder, substance abuse and neuro-immune disorders. These disorders have a genetic background, but the genes involved are unknown. Genes do not act by themselves, but need to be regulated. The steroid end products of the hypothalamic-pituitary-adrenal (HPA) axis, glucocorticoids, are as primary hormonal mediators of the stress response, extremely important for this purpose. These hormones are essential for maintenance of homeostasis, behavioural adaptation and survival. However, if the stress hormones circulate in too low or too high concentrations, or if their action is mismanaged, they cause neuronal atrophy and chemical imbalance enhancing vulnerability to stress system disorders in genetically predisposed individuals. Objective: The objective of the Summerschool is to bridge the gap between clinical symptomatology of stress system disorders in the brain and basic science. As Leitmotiv we use glucocorticoids, which are molecules par excellence for integration of brain and body functions during development, aging and stress under healthy and diseased conditions.The pathogenetic role of the steroids is examined as well as the potential of steroid- induced mechanisms to promote restorative capacity still present in the diseased tissue. Content: The Summerschool guides the student through the stress system on various levels of biological organisation from genes, neurons and circuits to system physiology and behaviour. Animal models for stress system disorders are based on variations in gene-environment interaction including either exposure to adverse conditions such as early t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targetting VAP-1 to treat chronic inflammatory liver disease' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Chronic inflammatory disease affects almost one third of the EU population and an increasing proportion of this burden is made up of liver disease. Large increases in death rates from chronic liver disease and cirrhosis have occurred in many EU countries and are predicted to continue. Chronic inflammation and cirrhosis develop in response to liver injury mediated by a wide range of reagents from hepatitis viruses, to alcohol and autoimmune processes.In all cases, persistent inflammation drives the progression and severity of disease but there are currently no effective therapies that modulate or switch off chronic inflammation. There is therefore a pressing need for a greater understanding of the mechanisms of chronic inflammatory liver disease as well as for the development of new therapies. The need is best addressed through action at a Community level to establish and maintain long term collaborative studies aimed, in the long term, at the development of new drugs.The applicants have demonstrated a critical role for the endothelial adhesion molecule VAP-1 in the recruitment of effector leukocytes to the liver and that it is the recruitment of effector leukocytes that sustains chronic liver inflammation. One of the applicants has developed novel therapeutic reagents based on antibodies and small molecule drugs to inhibit VAP-1 function.The current proposal has the objective to consolidate and further develop a partnership between the groups using the expertise in the academic group to explore new avenues in VAP-1 research and test candidate anti-VAP-1 therapies developed by the SME in both human in vitro and animal in vivo studies. This will be facilitated by the exchange of knowledge between the partners. The partnership will also strengthen the European biomedical s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A positron emission tomography apparatus based on liquid xenon with time of flight applications' (PETALO).

assistant: **Innovation**

This project presents a new technology for detectors used in positron emission tomography (PET), based on liquid xenon instead of current scintillator crystals. The basic element is a liquid xenon scintillating cell, with its size optimized to maximize the number of gammas that interact in the cell. Silicon photomultipliers read out by low power, low noise customized integrated circuits for time of flight applications will be used as sensors.Xenon is a noble gas which scintillates as response to ionizing radiation. Scintillation is very fast and intense, which results in the possibility of building a PET of good energy and spatial resolution and excellent time resolution. This, in turn, makes possible the measurement of the time-of-flight (TOF), which increases the sensitivity of the detector. Recently, the PI has published a Monte Carlo study of the coincidence resolving time that can be achieved by the PETALO technology, obtaining the promising result of less than 100 ps FWHM, which would be a break-through in the PET scanner field. The low cost of liquid xenon compared to conventional scintillating crystals opens two possible applications: one one hand, a full body PET reducing the cost and with an already better performance than the current technology; on the other hand, a smaller brain scanner, optimized to maximize the improvement in the performance with TOF measurements.This project will demonstrate the technological and commercial feasibility of the proposed technology. For this purpose, first a set of prototypes with two cells will be built to evaluate the resulting performance of the PETALO technology using different kinds of photosensors (UV light sensitive SiPMs versus conventional ones coated with a wavelength shifter). In a second phase, a full ring of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New multisensory technology for early intervention in infants with visual impairment' under Horizon Europe.

assistant: **Concept**

Visual impairments are disastrous for infants. They affect the infants’ reaching and motor skills, space perception, playing, socializing, physical functioning, psychological well-being, and health service needs. Therefore, early therapeutic interventions aimed explicitly at fostering these abilities are needed to improve the quality of life of people with visual disabilities. Effective rehabilitation technologies to enhance visually impaired infants' skills depend critically on a better understanding of the neuroscientific bases of multisensory and body processing. However, to date, these abilities can only be assessed qualitatively based on observational approaches. Due to the complexity of conveying a signal to visually-impaired infants that they will assuredly understand, technological solutions providing a quantitative output for visually-impaired infants are unavailable. With iReach, we aim to solve this problem. Specifically, we will design, develop and propose for commercialization a multisensory system that will provide non-invasive recording and training of the sensory-motor skills in visually-impaired infants. It will be compatible with simultaneous measures of behavioral and brain activity responses (e.g., electroencephalography). This technology will be designed based on realizing four concomitant tasks: (1) development of a novel rehabilitation technology conveying multisensory and bodily stimulation; (2) development of a quantitative method that will train and measure visually-impaired infants’ sensory-motor responses; (3) development of sensory-motor paradigms providing the audio and tactile spatial stimulations associated with body movements; (4) dedicated pipelines to analyze infants’ response to multisensory stimulations and with regard to body positi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'REsearchers in Industry and ACademy for Technology Development' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In liaison with the objectives of the Researchers’ Night initiative under the Framework programme of the European Commission, and the previous experience of the consortium, the project REACT sets as its main goal to enhance public recognition of researchers and their role for economic growth and quality of life and to encourage young people in Bulgaria to embark on scientific career. Especially the accents towards young generation will be stressed on as the European Partnership for Researchers once more time confirm the urgent need of increased efforts towards overcoming the problem not only with the shortages of researchers in some regions and industries but also growing ageing of the research labour force. The situation will get worse if young people are not attracted into the profession and if the present under-representation of women in science and engineering is not addressed.For achieving the main goal, the following project objectives are defined:-to disclose to the public the hidden sides of life and work of researchers, and to break down the stereotypes of scientists especially towards their age;-to raise the public awareness on the contribution of researchers to economy and society, to its progress and development and to tackle the existing prejudice towards their profession to be abstract and not linked to everyday life;-to show to large public the central role of researchers in the economy and benefits they bring for increasing economic competitiveness and quality of life;-to highlight the EU emphasis and large support to its researchers and the mobility opportunities for them in the large European labour market;-to make science and the respective career attractive for young people introducing them the collaboration between industry and academia and possibil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function' (CHAngeing), addressing dissemination and exploitation.

assistant: **Impact**

Cerebrovascular diseases (CVD) represent a major public health burden in Europe, afflicting, in particular, Easter Widening Regions. By bringing together a multidisciplinary and cross-sector agenda, CHAngeing will transform and interconnect two quadruple helix-based excellence ecosystems located in southern Europe (Portugal and Greece). This will be accomplished by science-based interventions: 1) promoting healthy lifestyles supported by Mediterranean diet culture to prevent CVD; 2) improving health technology-based rehabilitation of stroke patients. The objectives of CHAngeing are aligned with call outcomes, are supported by the Smart Specialization Strategy (RIS3) of both regions, and will contribute to deliver impact in both hubs and between hubs, in a synergistic manner: 1) reinforcing the excellence of both hubs as poles of attraction of new talents; 2) developing a common R&I strategy on ageing research, supported by action and investment plans; 3) promoting a culture of cross-sector fertilization in R&I and student’s training in both regions and across regions; 4) building strong links between research and business, filling innovation gaps and foster knowledge transfer and job creation; 5) implementing pilots and demonstrators towards healthy lifestyles and rehabilitation of stroke patients; 6) efficiently communicate, disseminate and exploit results of CHAngeing, ensuring high societal impact and long-term sustainability. The proposal encloses seven work packages: WP1- Coordination and management; WP2- Exploitation and sustainability (action and investment plans); WP3- R&I strategy; WP4- Advanced training and twinning; WP5- Connecting academia & business; WP6- Pilots & demonstrators; WP7- Communication, dissemination and societal impact. CHAngeing will be a cata
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Network for Medieval Arts and Rituals', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Even though it is a cliché that most Byzantine arts originated in, for and as rituals, scholars largely neglect their ritual origins and functions. Medievalists tend to treat visual, literary and performing arts as distinct from each other. In the medieval world, however, these arts were often combined to produce effective rituals. Recognizing the importance of considering these three arts together, NetMAR will use the concepts of “ritual”, “ritualization” and “performance” to bring together all types of Byzantine arts under one roof. Given the importance of Cyprus within the Byzantine and Western medieval worlds, NetMAR will use the same approach for Western medieval arts where they coexisted and interacted with their Byzantine counterparts.  Building on twinning’s huge potential for knowledge transfer, training and exchange of best practices between the three partnering institutions, NetMAR will work towards filling the networking gaps and deficiencies between UCY and its advanced partners in the field of Medieval Studies. NetMAR will also have a dedicated focus towards both promoting the involvement of female and male ESRs in the coordinating institution and strengthening its research management and grant writing skills. Furthermore, NetMAR will participate in the production of new tools and services that will benefit the tourism and culture industry, along with other interested stakeholders and public authorities.  The collaboration of the three partners, which mainly aims at strengthening the abilities, networks, skills and knowledge of UCY, will be performed within the framework of a number of CSA including: staff exchanges, expert visits, webinars, workshops, conferences and a summer school, as well as dissemination and outreach activities. These CSA will enable