RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Unravelling ChemoResistance mechanisms and improving first-line therapeutic strategies in high-grade serous Ovarian Carcinoma using multi-culture patient-derived organoids', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

To improve the poor clinical outcomes in high-grade serous ovarian carcinoma (HGSC), we need to understand the cancer cell-tumour microenvironment (TME) dynamic interactions upon disease evolution and treatment. In my proposed project, I will establish a unique TME-HGSC patient-derived organoid (PDO) multi-culture model system to identify and understand how the TME impacts treatment responses and how treatment resistance can be overcome.To generate multi-culture PDO preclinical models of HGSC for the first time, I will use my own expertise in 3D culture and stromal cell isolation from patient-derived material, and I will integrate self-generated “TME units” with well-characterized HGSC PDOs established at the host laboratory. I will then use this model to study the chemotherapy-induced changes at the single cell level. I will compare the transcriptional states of the treated models to the interval/recurrent PDOs and correlate their in vitro treatment responses to the patient responses. I will predict strategies to increase the sensitivity of the cancer cells to the HGSC standard treatment by targeting the tumour-TME interactions or the cancer cells themselves without generating a more tumour-supportive TME, by using the multi-culture PDOs in high-throughput drug screens and subsequently integrating the generated data. Finally, I will functionally validate the predicted therapeutic strategies by CRISPR gene editing and drug treatment of the models.I expect that my project will generate profound knowledge on the chemoresistance mechanisms in HGSC and provide the scientific community with a unique experimental model that incorporates the TME to state-of-the-art HGSC PDOs. In addition, this fellowship will allow me to enhance my international visibility through high-impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'From light fueled self-oscillators to light communicating material networks'.

assistant: **Innovation**

ONLINE aims to develop new concepts of communication between inanimate materials.What is meant by communication? In biological context, communication refers to interactive behaviour of one organism affecting the current or future behaviour of another. In the context of bioinspired materials, ONLINE will develop life-like material structures that communicate with each other via physical contact, fluidic medium, or optical beams. These inanimate materials will be coupled to form networks that communicate autonomously through light.How to make them? The core concept behind the communicative materials is self-oscillatory (self-sustained) motions in light-responsive liquid crystal elastomers (LCEs). Self-oscillation is a responsive structure that can self-sustain its own mechanical motion in a constant energy field. It captures the key concepts of living organisms, i.e., functioning out of thermodynamic equilibrium and energy dissipation. My goal is to scale down the self-oscillator concepts to the micro-scale and realize soft material robots that can communicate.Why is this important? There exists an increasing need for artificial materials that can interact, alike biological systems. However, all the dynamic features of state-of-the-art responsive materials are based on internal material properties, and making individual materials interact with each other is a huge challenge. ONLINE proposes three new model systems for material communication: (I) Microscopic walker swarm, in which the locomotion and patterns of interactions between individuals can be fully programmed; (II) Cilia array that move cooperatively and self-regulate the fluidics at low Reynolds numbers; (III) Homeostasis-like light-communicating coupled network that provides a full set of tunable parameters to mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New aeschylus edition' (NAE), addressing dissemination and exploitation.

assistant: **Impact**

The professor Vittorio Cittì is the Director of a Group of researchers, whose fundamental work Hypotesis also leads the politic of the Department of Philological and Historical Sciences of University of Trento: it is necessary to make a new edition of the text by aeschylus that takes into account:1) The specificity of his language whose the ancieny scholars were awfully aware, and2) the poetics that is drawn from the judgments made by these ancient scholars. In this aim, it will be necessary, first to make a new collation of the manuscripttradition.This collation will only be possible thanks to a transfer of knowledge by the requested expert in paleography. This expert will have to distinguish the different historical strata of the text inside of most corrected manuscripts and to put in light the origins of the vulgate. For many years the department of trento has already been involved in two major program of reasearch collaboration with foreign universities.These programs are essentially concerned with the re-examination of the history of the text by Aeschylus, which interests a lot of European hellenists at the moment:1) the international doctorate, which is managed by the universities of Trento (the administrative centre), of Cagliari and of Lille3 (as soon as we hope also the EHESS in Paris and Barcelona). In these Universities a strong research team composed by Phd Students, researchers and professors as been created, in order to work on the tragical poet.2) The team that collects all the aeschylean congectures in the aim of a New Repertory of conjectures in Aeschylus; on this work Europeans scholars collaborate under the leadership of doctor Roger D. Dawe senior fellow of the Trinity College (Cambridge), who is the best expert in the world on the manuscript and pri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Distributed Inference for Energy-efficient Monitoring at the Network Edge' (DIME) under Horizon Europe.

assistant: **Objectives**

Today, Internet of Things (IoT) sensors are being extensively used for monitoring processes/phenomena in smart cities. The data samples generated by these IoT sensors are wirelessly transmitted to servers at the network edge where compute-intensive Machine Learning (ML) models, specifically Deep Neural Networks (DNNs), are used for providing inference. However, a large percentage of data samples are redundant because they do not (significantly) improve inference. This leads to an excessive and unjustified carbon footprint of these systems as each redundant data sample will contribute to the Total System Energy (TSE) consumption. However, there is a lack of research on the design of these systems to reduce the TSE by considering the redundancy in the data. In DIME, we explore the TSE energy savings in a distributed inference setup by envisaging the deployment of the emerging small DNN models on the IoT sensors. My objective is to maximize TSE energy savings by answering two key questions: 1) when should an IoT sensor sample the process (to reduce redundant samples) and 2) where to do the inference on the sample, on the IoT sensor or at the edge server (to reduce TSE)? I will develop a general modelling framework and subsequently design and validate scheduling algorithms and sampling techniques that minimize the TSE by reducing the redundant data and maximize accuracy in ML-based monitoring systems. To achieve the objective, I will leverage my theoretical research experience on modelling and design and analysis of algorithms and the expertise of IMDEA Networks in applied machine learning and systems research. DIME directly contributes to reducing the carbon footprint of monitoring in smart cities, which is in line with the goal of Horizon Europe to achieve 100 climate-neu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Dynamically Reconfigurable Quality Control for Manufacturing and Production Processes Using Learning Machine Vision'.

assistant: **Concept**

The main goal of DynaVis is the development of machine learning methods for embedded machine vision systems in production and manufacturing to achieve dynamically reconfigurable systems.Inspection of products by machine vision often has to solve the problem of how to implement a human decision-making process in software. Currently, this requires a step-by-step reprogramming or parameterisation of the software, which may last for several months until satisfying results are obtained. The results of DynaVis will enable us to use Human-machine cooperation to learn complicated inspection tasks instead of set-by-step improvements and adaptations of software.The project is foused on the development of trainable" machine vision algorithms and of appropriate machine learning techniques. In order to create such methods we will focus on the following scientific objectives:(1) machine learning methods for processing the complicated data produced by the vision system.(2) methods to deal with multiple, possibly contradictory input by the operators.(3) methods for predicting success or failure of the learning process in early stages of the training process.The project contributes to the objectives of the call by developing a new way how reconfigurability in automated systems can be achieved. In the case of DynaVis these are embedded machine vision systems such as smart cameras. The project involves advanced control such as fuzzy methods and neural networks. The goal is to use human-machine cooperation and machine learning to dynamically adapt the vision system to the operator's decisions.The project involves key players in the field of machine learning with a particular focus on machine vision. Companies from the machine vision industry and end-users from various fields complement the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bioactive polyphenolic compounds from brown macroalgae: A mechanistic study on pig gut health promoting effects (BioAlgae)' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Modern pig production hugely depends on in-feed antibiotics to control postweaning diarrhea (PWD) and improve pig gut health during weaning. However, the use of in-feed antibiotics and zinc oxide (ZnO) has already been banned in Europe prompting an urgent need for alternative solutions. Currently, there is emerging interest in various bioactive compounds from brown macroalgae such as the polyphenolic compound phlorotannin (Pt) as a potential alternative due to their diverse biological activities. Weaning in pig compromises not only short-term gut health or reduces energy status, or alters gut microbiota (GM), but also disrupts mucosal integrity increasing susceptibility to infection and negatively influencing long-term health. Therefore, it can be hypothesized that improving immune status, enhancing intestinal barrier functions, and inhibiting specific harmful microbes using Pt can lead to both short-term favorable GM profile and long-term beneficial impacts on immunity and resistance against infection. Therefore, the objectives of this study are to investigate the effects of Pt on the enteric pathogen such as E. coli, GM, mucosal immunity and intestinal barrier function, and how these effects can be utilized to mitigate PWD in weaned pigs. Given my background and my supervisors’ track record in the gut health as well as the use of macroalgae in livestock as alternative to antibiotics, I have firm conviction in the successful achievement of the objectives of this project. The effects of Pt are expected to be reflected in improved pig gut health, reduced mortality and enhanced productivity in weaned pigs. This has huge implications in Europe to fill the vacuum created by the banning of in-feed antibiotics and ZnO. Moreover, this research project can complement the skills
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Cultural Evolution of Neolithic Europe'.

assistant: **Innovation**

The last 30 years have seen the rapid emergence and growth of a new high-profile interdisciplinary field, the study of cultural evolution, which has produced novel ways of understanding human cultural and socio-economic behaviour. In particular, it has produced mathematical models derived from evolutionary biology demonstrating the importance of culture and history in understanding human cultures and societies, while at the same time taking into account the adaptive dimension. The field has seen a great deal of theoretical development and some empirical work, not least by myself and colleagues at the UCL AHRC Centre for the Evolution of Cultural Diversity and its predecessor. However, there has been no substantive attempt to bring the different sub-fields of cultural evolutionary theory and method together in an integrated fashion and apply them to large-scale case-studies in history or prehistory to address specific questions concerning the links between demographic, economic, social and cultural patterns and processes. The aim of this proposal is to do that for the first time and in doing so to provide the basis for a new account of the role of farming in transforming early European farming societies, c.6000-2000 calBC, focussing on the western half of Europe, where the available data are best. The project will have a major impact on the field of cultural evolution by providing a model example for cultural evolutionary studies of early societies in other parts of the world. It will also provide important new insights into the history of European society and give a significant impetus to re-orienting the disciplinary field of archaeology, making it part of the broader inter-disciplinary endeavour of evolutionary social science, as other researchers follow its example.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards symplectic Teichmueller theory' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Over the last decade, homological algebra has entered symplectic topology, largely thanks to the appearance of Fukaya categories in homological mirror symmetry. Applications of these new methods and ideas are still scarce. We propose a fundamentally new approach to studying symplectic dynamics, by studying the action of the symplectic mapping class group on the complex manifold of stability conditions on its Fukaya category. This can be seen as a first attempt to generalise classical Teichmueller theory to higher-dimensional symplectic manifolds. Many invariants arising in low-dimensional topology, including Khovanov cohomology for knots, are governed by the Fukaya categories of associated moduli spaces. We propose an ""uncertainty principle"" in topology, in which these invariants are intrinsically constrained by rigidity of this underlying categorical structure. Besides applications in topology, this suggests a framework for studying the sense in which topological complexity is the shadow of dynamical complexity.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Accelerated X-in-the-loop Environment for Small Satellite Testing'.

assistant: **Objectives**

The New Space is expected to become the biggest industry in human history. In 2023, the global space economy was valued at about $500B. The number of space probes is bound to thrive, yet their growth is unsustainable: developing spacecraft autonomy is paramount to remove the costs and limits of human-in-the-loop operation activities. However, developing resilient autonomous technologies requires extensive empirical testing in representative environmental conditions, and access-to-space costs are still prohibitive.AXESS offers a web-based Testing-as-a-Service platform dedicated to spacecraft systems and technologies. Erected over the EXTREMA Simulation Hub, AXESS provides an integrated testing environment in which high-fidelity, X-in-the-loop experiments of space systems are performed under a state-of-the-art accelerated framework. Moreover, AXESS allows adopters to embrace a more flexible and agile CI/CD philosophy, enabling automated testing of space software, firmware, and IP core designs on modules and testbenches that are representative of real space technologies and hardware. Access to the platform will be granted through a web-based user interface, from which it will be possible to configure the automatic and manual test routines, monitor and control the ongoing testing activities in real-time, and collect simulation logs and metrics. AXESS allows the users to carry out data-driven system design, debugging, and fine-tuning through all the phases of the system development lifecycle.The project follows a suitably devised pathway to cover technical validation activities and assessment of exploitation opportunities. AXESS has raised the interest of the leading sectoral players and space agencies, as witnessed by the letters of support attached.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New system-driven bioremediation of polluted habitats and environment' in the context of a Horizon Europe call.

assistant: **Objectives**

The objective of Nymphe is to develop bioremediation/revitalization strategies based on the assembly of systems of available and new biologics (enzymes, microorganisms, bivalves and earthworms, plants and their holobiont) developed and applied on matrices from different EU contaminated sites: groundwater, sediments (hyporheic zone), wastewater as well as industrial, and agricultural soils. The assembly of systems is guided using predictive microbial interaction models in the microbiome of the actual site matrix to be decontaminated. The best systems of biologics are reintroduced at the contaminated sites (4 plus 1 site for confined tests using genomically edited biologics). Nymphe target at least 90% removal of the pollutants occurring at the sites, e.g. plastics and pesticides in the agricultural soil, and chlorinated solvents/total petroleum hydrocarbon in groundwater and sediments of the industrial site. Besides, biologics and systems benefit from the development of platform technologies to: assemble stable consortia (adhesin+complementary auxotrophies), accelerate the evolution of the microorganisms, increase mobility of degradative plasmids, genomically edit bacteria to produce evolved enzymes, produce enzyme systems with recycling of cofactors, control the spatial distribution of biodegraders (3D-printing), protect them in harsh environments, facilitate redox processes by electromicrobiology, design self-sustaining redox biocatalysts. The bioremediation/revitalization strategies undergo a full assessment: ecological and environmental risk analyses (chemical, ecotoxicological and supportive analyses e.g., function and biodiversity of the microbiomes), technology risk analysis, life cycle assessment, life cycle cost, cost-efficiency analysis, biosafety & regulatory