RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'If you are not healthy you are out: how honey bees develop resilience towards invasive species events with an immune system at the colony level'.

assistant: **Innovation**

Honey bees, Apis mellifera, have experienced the full impacts of globalization, including the recent invasion by the parasite, Varroa destructor. This deadly mite has rapidly become one of the main causes of colony losses worldwide, with a huge economic impact on beekeeping. Despite the lethal effects of varroa, some colonies survive infestation. In such colonies, honey bees are able to work together to selectively remove highly parasitized brood, thereby limiting mite spread. Defensive hygiene plays a role at society level that parallels that of an immune system, and the social immunity it confers provides the basis for colony resistance to varroa and other brood diseases. How compromised individuals are accurately diagnosed, and how the collective actions of hygienic bees are regulated at colony level pose central but yet unsolved challenges.The BEE HEALTHY project aims to decipher the mechanisms that underpin collective behavioural defences against unhealthy brood in honey bee colonies. Four key breakthroughs support my high-risk high-gain and wide-scoped approach: (1) a new conceptual framework postulating that bees maintain the integrity of the colony by constantly assessing the wellness of conspecifics; (2) a new hypothesis that considers distinct hygienic behaviours as components of a single suite of defences that must be considered together; (3) a cutting-edge experimental strategy that tightly associates studies at the individual bee and superorganism colony level; (4) an integrative biology approach that combines chemical ecology and neurophysiology. This ambitious project promises an unprecedented journey in the understanding of social immunity. In the face of increasing threats from invasive species events, revealing how hosts adapt to detrimental foes has n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The European Mouse Disease Clinic: a distributed phenotyping resource for studying human disease' (EUMODIC), addressing dissemination and exploitation.

assistant: **Impact**

As a first step towards a comprehensive functional annotation of the mouse genome, EUMODIC will undertake a primary phenotype assessment of up to 650 mouse mutant lines. In addition, a number of the mutant lines will be subject to a more in depth secondary phenotype assessment.The EUMODIC consortium is made up of 18 laboratories across Europe who are experts in the field of mouse functional genomics and phenotyping and have a track record of successful collaborative research in EUMORPHIA. The EUMODIC consortium will build on the work in the EUMORPHIA project that delivered a comprehensive database ' EMPReSS - of Standard Operating Procedures (SOPs) that can be used to determine the phenotype of a mouse. EUMODIC has developed a selection of these screens, EMPReSSslim, which is structured for comprehensive, primary, high throughput phenotyping of large numbers of mice.We will also adopt innovative approaches to the generation and assessment of cohorts of age-matched mutants and controls for phenotyping. Primary phenotype assessment using EMPReSSslim will be undertaken in four large-scale phenotyping centres at the GSF, Germany; ICS, France; MRC Harwell, UK and the Sanger Institute, UK. Mutant lines will be made available from another EU initiative, the EUCOMM (European Conditional Mouse Mutagenesis) project which aims to produce conditional mutations in 20,000 mouse genes.A distributed network of centres with in depth expertise in a number of phenotyping domains will undertake more complex, secondary phenotyping screens and apply them to a subset of the mice which have shown interesting phenotypes in the primary screen. The partners will also develop technologies to refine EMPReSSslim and improve throughput of mouse phenotyping. A key element will be the continued develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Intramolecular optical microscopy with sub-nm spatial resolution in single biomolecules and single-protein sequencing'.

assistant: **Innovation**

Fluorescence microscopy has witnessed a true resolution revolution in the past decades. The invention of methods circumventing the classical diffraction limit of ≈200 nm has allowed researchers – for the first time – to reach sub-diffraction resolution with optical fluorescence microscopy. With these so-called super-resolution techniques, processes within cells can be observed at thus far unprecedented spatial resolutions. However, while incumbent super-resolution approaches enable researchers to resolve intermolecular distances between e.g. protein molecules in small protein clusters, the final frontier in optical bioimaging to resolve intramolecular distances in the sub-nm regime for single molecules is still elusive. With this research proposal, I want to develop and apply a paradigm-shifting imaging technology that allows intramolecular optical microscopy with sub-nm spatial resolution in single biomolecules.To achieve this goal, I will combine DNA-Point Accumulation Imaging Nanoscale Topography (DNA-PAINT) with DNA Exchange to overcome the current limit of optical nanoscopy in terms of spatial resolution. To do so, I will build a microscope with ultra-high stability and sensitivity. The project is conceived as an integral approach including the design of optics, instrumentation, labelling probes and data analysis.Such a capability provided by the project IntraMol would be a game changer in fluorescence microscopy, as it could – for the first time – allow scientists to resolve intramolecular distances e.g. within single proteins, thus enabling structural biology studies and provide insights into conformations of proteins even enable single-molecule protein sequencing using optical microscopy in situ.


**Keywords:** Super-resolution microscopy, DNA-PAINT, single-mol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Prediction of the life time behaviour for c/c-sic tubes as high and ultrahigh temperature heat exchangers (HITHEX)' to be submitted under Fifth Framework.

assistant: **Abstract**

The project will be used to demonstrate the applicability of structural CMC components for high and ultra high heat exchangers . Such heat exchangers are required to realize new power generation plants based on EXTERNAL FIRED COMBUSTION CYCLES (EFCC) or INDIRECT FIRED GAS TURBINES (IFGT) .The application limits will be determined for different oxidation protected C/C-Sic parts developed in a previous project .Life time behavior models will be created based on creep curves under different environments .The materials and structural components will be further improved based on the intermediate evaluation . Furthermore, new test methods will be developed, applied and standardized to measure directly on structural components and not only on model samples . The test methods will be evaluated in comparison to standardized tests according EN on samples .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bilingualism in Florentine and Tuscan Works (ca. 1260 - ca. 1416)' under Horizon 2020.

assistant: **Concept**

This project will undertake the first systematic investigation of the various literary documents that circulated simultaneously in more than one language in Tuscany, and especially Florence, between the mid-13th Century and the beginning of 15th Century. During that period, Florence was both a prominent literary centre in the vernacular, and home to a renewal of classical Latin eloquence. While both fields are well studied, their interaction remains largely unexplored. This research, at the convergence of several disciplines (literature, philology, linguistics and medieval history), has a strong pioneering character. It aims at changing the perception of medieval Italian culture and interpretation of the break between medieval Culture and Humanism.For this reason, the project will develop research in varying degrees of depth. First, it will provide the first catalogue of bilingual texts and manuscripts of medieval Tuscany. Organized as a database, this tool of analysis will stir innovative research in this field, some of which will be immediately promoted during the project. Secondly, two case studies, considered as important and methodologically exemplary, will be researched in detail, through the publication of two important set of texts, of secular and religious nature : 1. The vernacular translation of the Latin Epistles of Dante Alighieri; 2. A collection of polemical, historiographical, devotional and prophetical documents produced by the Tuscan dissident Franciscans in last decades of the 14th Century. Finally, the entire team, led by the PI, will be involved in the preparation of a synthesis volume on Tuscan culture in the fourteenth century viewed through bilingualism, entitled Cartography of bilingual culture in Fourteenth-Century Tuscany. From this general ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Risk and Development: Households and Firms' in the context of a Seventh Framework call.

assistant: **Objectives**

Poor households in developing countries face low and volatile incomes, with little access to forma credit and insurance. Households often resort to informal institutions in order to smooth consumption and foster investment. The extended family could be such an institution. We test for the relevance of the extended family as a provider of resources able to smooth consumption fluctuations and promote high return investment in non-collateralizable assets such as education. Climate risk and weather shocks are fundamental source of uncertainty. The possible increase in extreme weather phenomena, as well as the changes in the second (and possibly higher order moments) of the temperature and precipitation distributions, could have dramatic consequences for the poor. Lacking insurance against such shocks, the poor will have to take actions to smooth consumption in the short term to the possible detriment of the future by reducing or channeling investment towards low risk-low return investments and crops. Such weather shocks might also have adverse effects on health through direct and economic channels, and in segmented or imperfect markets similar shocks will impact local prices and therefore welfare of the poor. A proper account of such welfare effects require a well estimated system of demand, in particular when we depart from the unitary model of the household.Often households and firms are inextricably linked in developing countries, where micro-enterprises are prevalent. These firms are often small, informal and unproductive. Do they lack business and managerial capital? Can we bring them out of informality? And does formality cause higher productivity? The recent increase in credit available to the poor raises concerns regarding possible increases in default rates. We tes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Adoptive engineered T cell Trials to Achieve Cancer Killing' (ATTACK) targeting Seventh Framework.

assistant: **Abstract**

The aim of this research is to exploit technology for nucleic acid delivery through the clinical testing of adoptive engineered T cells to treat cancer. Recent innovative developments in cancer gene-immunotherapy have led to very encouraging early clinical results. However, the use of engineered T cells is a challenging and complex field with further development and more proof-of-principle trials needed. This proposal builds upon previous EU funded pre-clinical projects and comprises a multidisciplinary and translational research group with wide-ranging relevant expertise. Building on encouraging clinical results targeting NY-ESO-1 in melanoma and the availability of clinical grade vector, the consortium proposes to rapidly initiate two landmark studies in this field: the first to examine the activity of engineered T cells in oesophago-gastric cancer as an example of a hard to treat common epithelial cancer;  the second to undertake a randomised phase II study to determine whether an optimised cell production system developed by the partners improves the current clinical response rates in patients with metastatic melanoma treated with NY-ESO-1 targeted T-cells. Success in these trials will enable the consortia and others to carryout larger trials and potentially approval of this type of therapy as a treatment for multiple cancer types. The inclusion of a major industrial partner focused on cell therapy technology and two SMEs focus on the delivery of cell therapy will facilitate future development of this area following these trials; indeed the project also includes plans to further automate and streamline cell processing to facilitate this development. This project would enhance European expertise and competitiveness in an important emerging market. The research will a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Situationally aware innovative battery management system for next generation vehicles' (InnoBMS) targeting Horizon Europe.

assistant: **Abstract**

The core objective of InnoBMS is to develop and demonstrate (TRL6) a future-ready best-in-class BMS hard- and software solution that maximizes battery utilization and performance for the user without negatively affecting battery life, even in extreme conditions, whilst continuously maintaining safety. Concretely, the InnoBMS proposal will deliver a 12% higher effective battery pack volumetric density, a 33% longer battery lifetime and a demonstrated lifetime of 15 years. The results will be demonstrated using novel testing methods that give a 36% reduction in the testing time of a BMS. The results will be demonstrated in two use cases, one light commercial vehicle (Fiat Doblo Electric) and one medium-duty van (IVECO eDaily). The key outcomes will enable a cost reduction of 12% and 9.7% for passenger cars and light-duty vehicles, respectively. The core objective will be achieved through five technical objectives. 1) advanced hybrid physical and data-driven models and algorithms to enable a flexible and modular BMS suitable for a wide range of batteries. 2) Software for a fully connected and fully wireless BMS that acts as a communication server inside the vehicle E/E-architecture, the center of connection, on-board diagnostics and decision-taking for all battery-related information. 3) A scalable, fully wireless and self-tested BMS hardware that enables using different battery sizes at different operating voltage levels, and smart sensor integration. 4) Better battery utilization and exploitation using cloud-informed strategies and procedure. 5) A heterogeneous simulation toolchain and automated test methods.The consortium includes 2 vehicle manufacturers, 2 TIER1 supplier, 3 engineering companies, 2 universities (leading in e-power and electromobility), an RTO and 3 SME
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sensory Integration in the Striatal Microcircuit' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Motor behaviour requires the meaningful integration of a multitude of sensory information. The basal ganglia are essential for such sensory-motor processing and underlie motor planning, performance, and learning. The striatum is the input layer of the basal ganglia, acting as a “hub” that receives synaptic inputs from different brain regions, interacting primarily with the GABAergic striatal microcircuit. Sensory excitatory inputs to striatum arise from the thalamus and neocortex, targeting striatal projection neurons and interneurons.Previous work in basal ganglia focused mainly on their role in motor and reward related functions, but the functional role of striatum in sensory processing is largely unknown. In this study I will elucidate the principles of sensory processing performed at the striatal microcircuit. In particular, I aim to answer these fundamental questions:-How do striatal neurons integrate sensory input? How is sensory input from different sensory modalities integrated in the striatum? How are ipsi- and contralateral inputs integrated?-What are the respective roles of cortical and thalamic sensory inputs in striatal function?-How is the intra-striatal microcircuitry organized to support sensory integration?To address these questions I will use a combination of electrophysiological, optical, and anatomical methods, including:- In vivo whole-cell recordings from striatal neurons during visual and tactile stimulation.- Multi-neuron whole-cell recordings in corticostriatal and thalamostriatal slices.- Optical manipulation of identified neuronal subpopulations in slice and in vivo.The proposed study will provide a new understanding of sensory processing at the level of basal ganglia and may provide insights regarding basal ganglia dysfunction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Resilient Networked Control Systems'.

assistant: **Innovation**

The proliferation of networks and digital devices over the last decade has solidified their role as important building blocks of the world's economic and social foundation. Numerous emerging commercial, governmental and medical applications are vitally dependent on such systems, and there is undoubtedly a growing need for ensuring that these critical networked systems remain reliable and trustworthy despite malicious or non-malicious disruptions. To address this deficiency, the proposed project focuses on networked control systems (NCSs) and sets the following two-fold objective: (i) develop theory and techniques for monitoring and diagnosing faults or, more generally, abnormalities in NCSs, possibly under limited and/or corrupted information, and (ii) establish control strategies that provide resilience to (potentially malicious) interference while maintaining acceptable performance and while satisfying any privacy concerns that may arise in a given NCS. The research objectives of this project are very timely, since building NCSs that are resilient and trustworthy presents a significant hurdle to reaching the full potential of NCSs. The project will facilitate to the development of a new body of research knowledge by combining several research areas from Electrical Engineering, Computer Science and Applied Mathematics (such as fault diagnosis, supervisory control, detection and estimation, system-level diagnosis, distributed algorithms, and others). Apart from intellectual merit, the project will also be instrumental for the reintegration of the Prof. Hadjicostis (coordinator) into the European research arena, giving him the opportunity to establish a research group on Resilient Networked Systems at the University of Cyprus (host). This process will facilitate knowledg