RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mucosal antibody and B cell responses during Tuberculosis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb), kills up to 1.5 million people every year. Despite sustained scientific attention, there is no effective vaccine, multidrug-resistant Mtb strains are on the rise, and impoverished people with little access to long, expensive treatments continue to bear the brunt of disease.  A critical barrier to the development of an effective TB vaccine is our incomplete understanding of what constitutes a protective immune response.Accumulating evidence suggests a role for B cells and antibodies in preventing and alleviating TB. Existing studies show that some Mtb-specific antibodies found in blood may confer protection against infection. However, whether such protective antibodies exist at the site of infection and in what quantity remains unknown. The goal of this project is to characterise antibody responses in the lung mucosa of mycobacteria-infected mice and humans, and to assess their relationship to protection versus disease. First, I will identify the antigenic targets of antibodies isolated from lung and lymphoid organs of infected mice by proteomics.  Then I will use tetramer-based enrichment and single cell RNA sequencing to investigate the dynamics, transcriptional regulation and B cell receptor repertoires of lung-resident, antigen-specific B cells – the source of lung mucosal antibodies. Finally, I will translate these findings from the mouse model to humans, using bronchoalveolar lavage fluid from a clinical study of TB patients with different grades of TB susceptibility. This approach will allow me to assess the existence of these mucosal antibodies in humans and to investigate their function and protective potential. Combining the mouse infection model with this unique TB patient coh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Feasibility study for the further development and market launch of the Archimedes Universal Decision Support System for irrigated crops growers' (ARCHIMEDES), addressing dissemination and exploitation.

assistant: **Impact**

In the language of irrigated agriculture, the word ‘water’ means ‘problem’, and that problem is often a crucial one. This argument may sound pathetic but it is not at all exaggerated, particularly given the range of challenges, both economic and environmental, faced by the farmers engaged in this domain.So the need for universally applicable measures addressing the water misuse problem in agriculture is here and, obviously, the world has already realized it: various attempts are made to find a solution in different parts of the globe, including in Europe. The fact is, however, that the problem persists, and this is largely due to the lack of a verified scientific approach to ensure its effective yet inexpensive solution.Thus far.With this Project Proposal the applicant Archimedes UDSS LLC presents the scientific basis, already tested and proven on-field, together with the business concept for transforming it into a user-friendly decision support system (DSS) for irrigated crops growers. Practically, our prospective product is designed to answer all the key questions left open by the present alternatives, through:-A universal approach to the problem applicable to any crop, anywhere on Earth;-A solution underlying a complex of verified biophysical equations in line with the laws of nature, eliminating the need for additional measuring equipment on-field;-A DSS allowing precise scheduling the yield amounts by crops yet at the start of the growing season;-And last but not least, a green technology sparing both the freshwater as a resource and the nature as a whole.All this potential turns the future Archimedes product into an innovation able to disrupt the agro-consulting solutions market and change the very way irrigated farming is done. So we are up to shape the brighter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Disentangling the stringent response to engineer novel anti-persister drugs'.

assistant: **Innovation**

Bacterial “superbugs”, refringent to antibiotic treatments, have rapidly increased with the turn of the century. Slow growing, dormant cells (known as persisters) are subpopulations of bacteria that tolerate antibiotics and are considered a primary source of infections for antibiotic-resistant pathogens since they are difficult to eradicate in conventional ways. Mutations in RelA/SpoT (RSH), the effectors of the stringent response, promote antibiotic tolerance and persistent infections and are commonly selected in clinical settings of a variety of pathogens. However, despite the importance of the RSH-mediated stringent response, there is no comprehensive knowledge on the inner workings of the enzymes, or drugs that modulate the bacterial response to stress. Modern structurally biology is currently in the midst of a revolution comparable to that of the Genomic breakthrough of the end last century. This has facilitated access to structural information and increased the accuracy of the modeling and design of de novo structures of proteins and small molecules. Thus my overarching goal is to target key steps in the molecular mechanisms of ppGpp synthesis and hydrolysis catalysed by RSH enzymes, to discover active compounds against persisters. The highlight of this proposal is a new system biology approach that combines cellular microbiology (at a single cell resolution) with structural engineering, biophysical, biochemical and chemical-biology methods to design, screen and validate novel small molecule drug candidates targeting the stringent response. Based on preliminary keystone results from my group, we devised a proof of concept experiment for which we designed a catalogue of novel modulators of the stringent response customized to target bacteria in a specific or broad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sampling and Reconstruction driven by Sparsity Models with Applications in Sensor Networks and Neuroscience' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The problem of reconstructing or estimating partially observed orsampled signals is animportant one that finds applicationin many areas of signal processing and communications. Traditionalacquisition and reconstruction approaches are heavily influences byclassical Shannon sampling theory which gives an exact samplingand interpolation formula for bandlimited signals. Recently, theemerging theory of sparse sampling has challenged the waywe think about signal acquisition and has demonstrated that, byusing more sophisticated signal models, it is possible to break awayfrom the need to sample signals at the Nyquist rate.The insight thatsub-Nyquist sampling can, under some circumstances, allow perfectreconstruction is revolutionizing signal processing, communicationsand inverse problems.Given theubiquity of the sampling process, the implications of these newresearch developments are far reaching.This project is based on the applicant's recent work on the samplingof sparse continuous-time signals and aims to extend the existing theory to include moregeneral signal models that are closer to the physicalcharacteristics of real data, to explore new domains where sparsityand sampling can be effectively used and  to provide a setof new fast algorithms with clear and predictable performance.Aspart of this work, he will also consider timely important problemssuch as the localization of diffusive sources in sensor networks andthe analysis of neuronal signals of the brain. He will, for thefirst time, pose these as sparse sampling problems and in this wayhe expects to develop technologies with a step change inperformance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'MICROALGAE PROTEIN INGREDIENTS FOR THE FOOD AND FEED OF THE FUTURE'.

assistant: **Concept**

ProFuture will set the basis for market uptake of innovative, healthy and sustainable food and feed products, reformulated with protein-rich ingredients from Spirulina, Lemon/lightly/Chlorella vulgaris, Tetraselmis chuii and Nannochloropsis oceanica. Multi-factors approach and LCA/LCC will boost sustainability of the microalgal biomass production and processing, by reducing energy/water consumption and the carbon footprint. Implementation of innovative technologies will increase the efficiency and decrease the production costs of biomass, ingredients and foods/feeds. Optimized workflows will be tested at pilot plant, as part of a biorefinery process, to produce single-cell proteins and protein isolates, which will be characterized for their nutritional, safety, techno-functional and organoleptic properties as well as for economic viability & sustainability. Food and feed will be formulated with the novel ingredients at pilot plant level in collaboration with SME and large companies. Single-cell proteins will be incorporated in foods (n=6) and feeds (n=5) which will be produced at industrial scale. The food/feed microalgae value chain in EU will be analysed and improvements will be proposed to increase the economic viability and the communication between actors. Social and economic benefits of innovative food and feed products will be demonstrated by: i) supporting the authorization of novel microalgae protein ingredients for food and/or feed applications in the EU, ii) assessing consumer acceptance of and preference for microalgae protein-based products, iii) preparing a successful market implementation and exploitation of the project results and iv) devising a dissemination and communication plan for maximum outreach to all relevant stakeholders. ProFuture consortium (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable Mobility, Affordable Cities: How do workplace sustainability plans shape transport affordability in Brussels and Sofia?' (SuMAC), addressing dissemination and exploitation.

assistant: **Impact**

‘Sustainable Mobility, Affordable Cities: How do workplace sustainable mobility plans shape transport affordability in Brussels and Sofia?' is a 2-year research action. The project involves an innovative comparative study of workplace mobility management programmes in Brussels, Belgium and Sofia, Bulgaria. The research will shed light on the socio-economic effects of environmentally-focused mobility measures. The action will use a mix of qualitative and quantitative research methods to examine the effects of workplace sustainable mobility plans on transport affordability for participating employees. The focus will be specifically on small privately owned businesses, and low-wage employees in sectors such as catering, cleaning and retail. These are sectors which have had limited involvement in sustainable travel planning to date. Alongside gathering key data, the project will help identify practical approaches to involving small employers in such inititatives.Sustainability interventions in most European cities, including Brussels and Sofia, have had limited success to date in engaging such sectors in workplace mobility planning. Because of this, the research action incorporates an initial stage of identifying and recruiting up to four interested small employers, and working with them collaboratively to develop their workplace sustainable mobility plans. Following on from this initial phase inspired by action research methods, a quantitative survey and in-depth interviews will be used to grasp the effect of the sustainability measures on affordability. The unit of analysis will be the household, reflecting its importance in shaping travel behaviours. A mixed-method approach will incorporate quantitative aspects of expenditure alongside accessibility and everyday mobility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'My Ideal City' in the context of a Seventh Framework call.

assistant: **Objectives**

The M.I.C. (My Ideal City) project aims to encourage a European dimension in the communication of science and technology through museums events targeting the public. More specifically, it will support the networking around the development of a coordinated exhibition in different museums, in Member and Associate Countries, that is going to use a “virtual worlds” dimension in order to connect urban planning choices and the awareness of citizens about them, and an International Conference that will bring together academics and science centers to discuss the relationships between urban planning, cyberspace, and science events. The exhibition is going to provide visitors with a “virtual worlds” environment that will re-produce in alternative and different ways their own city as well as the other ones involved in the project. The new cities, the “ideal” ones, will make possible for citizens to re-think their urban environments and the choices done in order to make it as it appear in the virtual environment. The project will not only provide citizens with an exhibition able to raise socio – cultural awareness in relation to the urban choices, but also involve them in the planning of the “ideal cities”, giving another contribution to the spread of an open an transparent process of communication between science (sustainable urban planning), technology (the virtual environment), institutions (science centers) and people. After the exhibition evaluation, the organization of an International Conference will take place, in order to make the awareness about the potential of the mixture developed in the exhibition spread around Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Silicon transport proteins in biological nanoscience and synthetic biology' (IMPLANT).

assistant: **Concept**

This interdisciplinary proposal will investigate whether the activity of a unique family of membrane transport proteins can be harnessed to develop novel strategies for the bioinspired fabrication of nanoscale materials and provide new directions in synthetic biology. Silicon transporters (SITs) are integral membrane proteins that were first identified in the diatoms, single–celled eukaryotic algae that surround themselves with a cell wall of hydrated silica. The biosynthesis of this ‘glass house’ depends upon the uptake of silicic acid, the soluble form of silica, from the environment. The SITs bind silicic acid with high affinity and transport it across the cytoplasmic membrane into the cell. Under this proposal the SITs will be recombinantly expressed and purified before being reconstituted into synthetic liposomes. The resulting proteoliposomes will be energized to drive SIT-dependent transport of silicic acid into the interior lumen. Since the lumen has dimensions on the nanometer length scale and attolitre volume, the proteoliposomes will act as discrete nanoreactors for the synthesis of silica nanoparticles. Using SIT proteins to deliver silicic acid to the growing nanoparticle offers an unprecedented degree of tunable kinetic control over the synthetic conditions that, together with the lumen microenvironment, may induce novel particle morphologies or properties. This principle will be extended in two further directions. First, encapsulating preformed inorganic nanoparticles in the liposome lumen will lead to the formation of core-shell nanoparticles with a functional core and passive silica shell. Using SITs to control the supply of the synthetic precursor will provide unparalleled tight control over the thickness of the silica shell. A second element will crea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy'.

assistant: **Objectives**

Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than stimulating proliferation. This suggests that cancer cells have acquired mutations that help them cope with aneuploidy. Although it is clear that aneuploidy can contribute to cancer, the molecular consequences of aneuploidy remain elusive, as does how aneuploidy contributes to malignant transformation. The scientific aim of this network is to determine and compare the molecular consequences of different levels of aneuploidy, both in vivo and in vitro. Our network will train 9 Early Stage Career and 2 Experienced researchers in the aneuploidy field. To this aim, we are combining the expertise of labs that study the causes of aneuploidy with labs that induce aneuploidy in model organisms and study its consequences and also with labs that focus on the development of therapeutics that selectively kill aneuploid cell progeny. Our network is comprised of 11 full participants in 4 member states and 1 associated country and one associated partner, and includes 3 commercial enterprises. Within this network, we will provide technical training through research projects, but also through workshops and dedicated courses organized by the participants of this network. A significant part of the training will be provided by the industrial partners. Participating investigators and trainees will meet at a yearly conference to exchange and discuss results. Trainees will thus become experts in the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Atomic Fermi Gases in Lower Dimensions'.

assistant: **Innovation**

The complex interplay between Coulomb repulsion and Fermi statistics in two dimensional systems is responsible for some of the most dramatic phenomena encountered in solid state physics (High critical temperature superfluidity, Fractional Quantum Hall Effect,..). However, despite decades of efforts, many questions regarding these systems are still unsolved.  In FERLODIM, we plan to take advantage of recent progress in ultracold gases, to simulate several fundamental Hamiltonians describing these many-body systems in 1 and 2 dimensions. We will realize two ultra-cold atom machines allowing for a full characterization of the many-body wave function of an ensemble of interacting fermions in periodic potentials, called optical lattices.  Our experiments will rely on a high resolution imaging system allowing both for single atom detection and the possibility of tailoring optical potentials of arbitrary shape and geometry.  This unique design will allow us to address a variety of physical situations, depending on the geometry of the light induced potentials. One-dimensional problems will be addressed, from spin chains to Luttinger liquids.  In pure two dimensional configurations, we will investigate the link between the repulsive Hubbard model, superfluidity and the Mott insulator transition, as well as frustration effects in periodic potentials. Finally we will explore the physics of interacting fermions under rotation in the lowest Landau level, and the connection with fractional Quantum Hall systems.