RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Biological production of novel organofluorines via terpene biosynthesis and S.cerevisiae engineering'.

assistant: **Objectives**

Fluorine offers unique properties that are invaluable in molecular design and discovery. Its importance is evidenced by theoverrepresentation of fluorine among synthetic small molecule therapeutics. However, unlike synthetic chemists, nature rarely uses fluorine as part of its design tools to construct bioactive molecules. To introduce fluorine into complex scaffolds such as natural products would offer enormous potential for accessing new structural space that combine beneficial features of biological and synthetic molecules for the discovery of novel functions. This proposal, Bio-fluorine, aims to explore the incorporation of fluorine into terpenoids, which constitute the largest and most diverse class of natural products, using biosynthetic enzymes. The proposed research seeks to develop an entirely enzymatic pathway to incorporate fluorine from a simple precursor into diverse carbon skeletons. The proposed work also aims to develop a Saccharomyces cerevisiae chassis for scalable biological fluorine incorporation and novel organofluorine production.


**Keywords:** Biosynthesis, Fluorine chemistry, Synthetic biology, Metabolic engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Evaluation of ratioNally Designed Influenza vaccines' (ENDFLU) under Horizon 2020.

assistant: **Objectives**

ENDFLU will develop three complementary next-generation influenza vaccination strategies for the world, fueled by the unique combined expertise of Indian and European partners  in rational vaccine design and development:• Create a repository of pre-pandemic GMP-compliant MVA-based vaccine seeds, each encoding an influenza hemagglutinin (HA), based on European partners demonstration of clinical safety and cross-clade immunogenicity of MVA-H5.• Optimize and select protein- and MVA-based constructs developed by Indian and European ENDFLU partners, resulting in a rationally combined vaccine formulation that induces broadly protective humoral and cell-mediated immunity against all influenza manifestations.• Pre-clinically advance other promising protein- and MVA-based constructs toward future development beyond ENDFLU. Constructs to elicit humoral immunity build on rationally-designed and optimized conserved epitopes of influenza surface proteins, HA stem- and HA head-nanoparticles, and NA-M2e fusions either as proteins or MVA expressed. Other MVA-based constructs to elicit cell-mediated immunity will encode conserved internal protein T cell epitopes, as an artificial polyepitope. The best candidates will be selected based on biochemical, biophysical, functional and manufacturing criteria, and immunogenicity and protective efficacy in mice and ferrets. The selected protein-based construct will enter a Phase I clinical trial in Europe assessing safety, immunogenicity and optimal dose, to be combined with the selected MVA-based construct. This protein-MVA combination will be GMP produced and toxicologically tested, including in combination with the protein-based construct, for clinical readiness. A dissemination and exploitation plan, and collaboration with key scientific advo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'INP-based micro-mechanical tuneable and selective photodetector for wavelength division multiplexing systems' (MOEMS) targeting Fourth Framework.

assistant: **Abstract**

The objectives of this research project is to design and produce novel widely tunable and selective photodetectors based on InP and related materials and combining optical and micro-electro-mechanical functions. The key performance goals will be those requested by Wavelength Division Multiplexing Systems (WDM) for telecommunication applications. The project combines the technology for optoelectronic-integrated circuits (OEICs) and Micro-Electro-Mechanical systems (MEMS), thus creating Micro-Optelectro-Mechanical Systems (MOEMS). Wavelength-selectable receivers will be implemented using an optical Fabry-Pérot resonant vertical cavity integrated with a photodetector. Continuous wavelength tuning will be obtained through micromechanical deformation of the vertical cavity by a movable membrane. These photodetectors will be an important component for WDM systems, combining in one device low control power, low insertion loss, no polarisation dependence, simple fibre coupling and reasonable tuning speed.WDM system technology is currently considered world-wide for upgrading of telecommunications networks. Many network operators in Europe and elsewhere have plans or are starting to develop plans for introduction of WDM systems. Also, many manufacturers of telecom equipment are developing components, subsystems and systems for WDM, including the two industrial partners in this project, Thomson and Ericsson. A key device in any WDM implementation is the wavelength-selective receiver. In this project we will develop a new, compact and potentially low-cost technology that allows monolithic integration of a wavelength filter function and photodetector function. Direct exploitation of this technology is envisaged if competitive results are obtained.Approach to be takenThe devices to b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular and Functional Characterisation of Z-nucleic Acid-induced Signalling' under Horizon Europe.

assistant: **Concept**

Nucleic acids are potent activators of an immune response. Z-nucleic acids are poorly defined and thermodynamically unstable conformers of double-stranded RNA/DNA helices. Recently, others and our group showed that Z-nucleic acids are recognised by the nucleic acid sensor ZBP1, thereby inducing an antiviral immune response. Activation of ZBP1 has also been shown to induce anticancer immunity and it is becoming clear that chronic engagement of ZBP1 by endogenous Z-nucleic acids causes autoinflammatory pathology. On top of that, a remarkably diverse set of cellular insults, ranging from pathogens and chemicals to genetic mutations trigger ZBP1 activation. Despite its relevance in these important (patho)physiological events, knowledge on the fundamental principles that govern Z-nucleic acid-induced ZBP1 signalling is lacking. I here propose that ZBP1 perceives these widely different disturbances in cellular physiology by detecting the increased intracellular concentrations of Z-nucleic acids. Based on a newly developed ZBP1 activation model and using nanopore sequencing, structural biology and chemical or genetic perturbation methods, we will: (i) characterise the molecular mechanisms that regulate Z-nucleic acid levels, (ii) determine the biophysical determinants of ZBP1 activation, (iii) map the ZBP1 downstream signalling network and (iv) functionally validate our novel findings in cellular and in vivo models of ZBP1 activation.The resulting detailed mechanistic understanding of ZBP1 function from single molecule to organism will enable us to develop future strategies for therapeutic interference with ZBP1-mediated immune responses, either negatively, to resolve autoinflammation, or positively, to promote antiviral or anticancer immunity.


**Keywords:** Nucleic acid imm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Very High Speed Serial Interfaces', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Space-based Earth observation and scientific instrumentation currently under development will push the limits of on-board data-handling technology. In the past Mil-Std 1553 and proprietary data-links were used to get instrument data from the instruments to the on-board mass memory unit and to the down-link telemetry system. Over the past decade the proprietary data links have been replaced with a standard networking technology designed for use on-board spacecraft: SpaceWire. While SpaceWire is currently being used to fulfil the on-board data-handling requirements of many missions, there are some very high data-rate instruments which are beyond its capabilities.Several future space-based instruments, for example synthetic aperture radar (SAR) and hyper-spectral imagers, will be capable of producing data at data rates of several Gbits/s. New downlink telemetry techniques will be able to provide much higher downlink capacity than previously possible. High speed memory technologies will be able to serve multiple high data rate instruments and stream data to ground on demand. To support the growing demand for onboard communications network bandwidth, technologies able to support multi-Gbits/s data transfer have been developed, unfortunately these are all restricted USA devices resulting in a critical European dependency.ESA has been developing a standard multi-Gbits/s network technology called SpaceFibre. At present this important ESA technology is dependent upon the USA for the radiation-tolerant physical layer devices. The SpaceFibre-HSSI project plans to integrate two or more complete SpaceFibre interfaces together with the physical layer devices in a single radiation tolerant ASIC manufactured by a European foundry. Not only will this alleviate the dependency on very hig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Open service network for marine environmental data'.

assistant: **Innovation**

NETMAR aims to develop a pilot European Marine Information System (EMIS) for searching, downloading and integrating satellite, in situ and model data from ocean and coastal areas. It will be a user-configurable system offering service discovery, access and chaining facilities using OGC, OPeNDAP and W3C standards. It will use a semantic framework coupled with ontologies for identifying and accessing distributed data, such as near-real time, model forecast and historical data. EMIS will also enable further processing of such data to generate composite products and statistics suitable for decision-making. NETMAR will develop interoperability and connectivity between heterogeneous data systems to meet the demand for information from different user groups. Standardising data and metadata formats, as well as exchange protocols, are the first steps to bridge existing marine data systems. The next step is to define the semantics of the services, including an uncertainty model, to allow transparent computer-based discovery. Developing a semantic framework for marine data services, backed by a multilingual and multidomain ontology enabling searches across (human) languages and application domains, is therefore a key task. EMIS will enable search for and use single services, as well as to compose new and more powerful services by service chaining, defining the workflow of the composite service using existing services as building blocks". EMIS will then merge established standards and tools with these new "building blocks" for application in practical monitoring of the marine environment. This will be done through a set of use cases in different European seas, where identified users will test and evaluate the EMIS. The use cases include monitoring and forecasting of oil spills, pla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Fine Structure and Regularity of Moving and Stationary Free Interfaces'.

assistant: **Concept**

Free boundaries and interfaces arise in problems in PDEs and Calculus of Variations, in which both the solutions and their domains are free to evolve in time. Several physical models and phenomena naturally lead to the formation of free boundaries and interfaces, for instance, phase-transition (the Stefan problems), periodic water waves (Stokes water waves), jet flows (the Bernoulli problems), tumor growth and congested crowd motion (Hele-Shaw flows), strong segregation (optimal partitions; harmonic maps).This project is dedicated to the analysis of the free interfaces from a purely theoretical point of view. The focus is on the Regularity Theory: starting from some very weak notion of solution and without making any a priori assumption on the shape and on the topology of its domain, we aim to describe the local structure of the free boundary and its evolution in time. Two phenomena will be central for the project: the formation of singularities in space and the persistence of these singularities in time. My main objective is to develop analytic methods for the description of the local structure of the free interfaces around such singularities. These results will have broad impact on the fields of PDEs and Geometric Analysis.


**Keywords:** Regularity theory, free boundary problems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Concerted action on forecasting prevention and reduction of landslide and avalanche risks' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

In several regions in Europe, especially along rivers and in mountainous areas, the topography and the geological structure is of such a character that the risks of natural catastrophes, e.g. landslides and avalanches, are evident when certain conditions are fulfilled. Hydrological, hydrogeological, geological and geotechnical factors influence the probability of the occurrence of such catastrophes, as do the interference with the natural environment by human actions, such as tourism and land-use. The aim of the Concerted Action is to increase the knowledge of risk assessment as well as monitoring and warning systems for landslides and avalanches by dissemination of RTD results and technology transfer. The focus will be on forecasting, prevention and reduction of risks. This principal aim shall be pursued by realising the following objectives: - Improve dissemination and exploitation of RTD results from current,successful Environment and Climate projects as well as nationally fundedprojects in the proposed RTD area - Promote technology transfer between European countries and provide a linkbetween research institutions and industry - Exchange of experience between experts of different disciplines (geotechnicalengineers, geologists, land-use planners, climatologists and hydrologists) - Contribute to market introduction of successful RTD results through workshopsfor researchers and users of geotechnological knowledge Within the scope of the work, the anticipated result of the Concerted Action's activities is to identify, develop and promote best practice. The Concerted Action will consist of two Expert Meetings and two Workshops in a period of two years. A Steering Group will be responsible for the planning and the delivery of the outputs from the Concerted Action.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'A System to Realise Dynamic Networked Organisations on Heterogeneous Networks in the Consultancy/Agency Sector'.

assistant: **Objectives**

The project supports working teams distributed over different cultural and geographic areas in planning and executing typical projects in the consulting/agency sector. The different players, i.e. the customer, main contractor, the sub-contractors and suppliers access the same system to organise and manage their project work.Reference models for project organisation and modular software system structures have been developed. Two prototype systems are implemented and evaluated through real world pilot scenarios. The final system uses widely accepted Internet standards to realise inter-organisational information flow and management.The objectives behind this approach are to present to European SMEs an affordable and easy to use Internet-based system in order to increase their competitiveness in the global marketplace. Companies from the media and/or consulting sector, which typically work in networks will particularly benefit by saving travelling and communication costs.Parts of the final DYNOCA prototype systems are exploited through the products GLONZ and ISIKnowledge, which are the commercial products of Artundweise GmbH (Germany) and ISO Informatique (France) respectively.1. Framework model of processes found in the consultancy / agency sector2. Framework model for Internet based software systems to support distributed teams3. Two prototype systems, which have been proven in pilot applications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Organic/Plastic Electronics Research Alliance' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

We propose to coordinate the work of academia and industry active in plastic electronics. The overall objective is to strengthen the position of Europe as the leading force in PE in the world.<br/>Our specific objective in Opera is to create the conditions for the establishment of a number of  competitiveness clusters in the EU, because competitiveness clusters have shown to provide a fertile substrate for the development of such leadership. There are a few areas that meet most requirements for a cluster:<br/>* The Aachen - Louvain - Eindhoven triangle<br/>* UK, Cambridge area<br/>* Germany, Dresden area<br/>* Finland, Oulu area<br/>* Switzerland, Basel area<br/>However, a number of key elements are missing from these embryonic clusters:<br/>PE has grown organically without a coherent overall strategy. This leads to duplication of efforts, inefficiency and poor synergy. These are major obstacles to the development of truly global force<br/>PE is still at too early a stage of development to justify massive investment from the end-user industry. This would allow the sector to grow beyond critical mass<br/>To address these issues, Opera has the following components:<br/>* The development of an overall pan-European strategic framework maximising synergy and cooperation within the sector, accelerating technological progress and the development of commercial PE applications<br/>* The creation of channels of exchange of ideas and people<br/>* The development of tools for stimulating entrepreneurship by the private sector and public administration<br/>* The acceleration of the development of industry standards for PE<br/>* Enhancing the visibility of the field to the 'outside world', stimulating the formation of 'crosslinks' with related fields<br/>The consortium consists of Eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An assessment of the impact of projects funded under Area 4 agriculture, forestry and rural development" of FAIR, Framework 4, on stakeholders - agricultural / forestry industry, scientific community, policy makers and EU citizens"' under Fifth Framework.

assistant: **Concept**

AGRI-IMP is concerned with making the first assessment since 1988 of the impact of agriculture and forestry research projects funded by the EU under the Framework Programmes. AGRI-IMP will use a combination of data collection methods to measure the differences made to stakeholders by the 239 projects in Area 4, FAIR, FP4, as determined against key indicators to be established.Besides testing this approach, the published results of the project and its methodology will help to inform the development and assessment of similar FP5 projects and future funding programmes (such as the next FP and ERA) and also provide a baseline for future assessments.