RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Vector-borne Risks for Europe: Risk assessment and control of West Nile and Chikungunya virus (VECTORIE)' to be submitted under Seventh Framework.

assistant: **Abstract**

VECTORIE provides for a multidisciplinary approach combining the expertise of (basic) virology, entomology and advanced vaccinology to monitor the spread of and diagnose, prevent and treat infections caused by West Nile virus (WNV) and Chikungunya virus (CHIKV). VECTORIE therefore addresses Europe’s need to prepare for these vector-borne diseases along three strands:Vector biology: WNV and CHIKV are emerging mosquito-borne viral diseases. Generating novel knowledge on avian and mammalian host susceptibility and vector competence of the two main vectors of WNV and CHIKV, will lead to important insights necessary for determining the type of surveillance system appropriate for European countries to detect and predict emerging WNV and/or CHIKV outbreaks.Virulence & pathogenesis: VECTORIE addresses the need for understanding how CHIKV and the four WNV lineages circulating in Europe differ in their capacity to cause neuroinvasive disease. These studies will improve Europe’s ability to monitor the spread of these infections and will lead to diagnostic and prognostic tools as well as novel intervention strategies.Vaccination strategies: The severity of WNV and CHIKV neuroinvasive disease, the long term sequelae reported from infected individuals and the negative impact of these infections on the blood transfusion system collectively justify the development of safe and effective vaccines against these infections. VECTORIE brings together a platform of technologies using either virus-like particles or Modified vaccinia Ankara vaccine candidates, for the development of novel mono- and bivalent vaccine candidates against WNV and CHIKV.VECTORIE’s integrated approach will largely contribute to adequate risk assessment and risk mitigation of the emerging health threat caused by WNV an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Diagnosing skewed X-inactivation in women - Tandem Repeat-based Identification of X-chromosome Inactivation (TRiXi)' in the context of a Horizon Europe call.

assistant: **Objectives**

Disease-causing mutations on the X-chromosome (‘X-linked’ disorders) typically only affect men. However, due to a genetic phenomenon called skewed X-inactivation (sXCI), thousands of girls and women in Europe also develop serious and often life-threatening X-linked disorders every year. As there is no reliable test for sXCI in humans, women carrying mutations are typically unaware of their risk, and when symptoms do develop, diagnosis is delayed. We have developed a method for quick, cheap and accurate detection of sXCI; Tandem Repeat-based Identification of X-chromosome Inactivation (TRiXi). We will take TRiXi from a cutting-edge research method to an in vitro diagnostic test for sXCI in female carriers of X-linked mutations. Following requests from clinical colleagues, TRiXi has been used to assess disease risk or confirm diagnoses for multiple life-threatening X-linked disorders in patients from Clinical Genetics Units across Sweden, confirming its real-world clinical utility and the unmet need for a standardized assay for sXCI in the clinic. TRiXi has additional commercial potential as a Research Use Only test kit to serve the large and expanding field of research into female medical health. I have filed a priority patent application for TRiXi, joined the business incubator at Linköping University, and assembled a team with expertise in business, patenting, and regulatory affairs to successfully translate my innovation. Over 1 million women are carriers of mutations for serious X-linked disorders, in Europe alone. This represents a large patient population requiring a better standard of care, that can be delivered by TRiXi, and a significant and largely untapped commercial potential. Over the next 18 months, we plan to: (i) establish a regulatory strategy for each m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Coordination of research on priority medicines for children' (PRIOMEDCHILD), addressing dissemination and exploitation.

assistant: **Impact**

The Dutch government commissioned the World Health Organization (WHO) to develop a research agenda for Europe, based on the public health need for new medicines, the so-called priority medicines. Medicines for children and pregnant women were raised as major public health priorities of the issues cutting across disease categories. In preparation of this ERANET Coordination Action (CA), the Netherlands Organisation for Health Re-search and Development (ZonMw) conducted an inventory of research programmes on priority medi-cines themes in Europe sponsored by the EC (SSA Priority Medicines 003214). The inventory identi-fied research on medicines for children as a most promising sub-area of priority medicines to focus towards. The CA will network and coordinate programme managers of national programmes to pool resources towards a common European goal and launch a joint European research programme on medicines for children (WP6). The consortium consists of key players in 9 European countries bringing together the national research councils, ministries and drug regulatory bodies/authorities which have the authority and the means to highlight research activities on the national agenda and to foster the implementation of the results of that research. By collaborating with relevant stakeholders, it develops a common research agenda on new, more effective and safer medicines for children. The CA will strengthen coordination of key players in European public research funding (WP2) and estab-lish an European research area for medicines for children. The project explores the ethical-regulatory framework (WP3) and public-private cooperation (WP4), and make recommendations for future re-search coordination. The partners will engage in the public debate on the topic by devoting a specif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Predicting Suicide'.

assistant: **Innovation**

There is a pressing need for improvements in methods that accurately measure and predict those most likely to engage in suicide and self-harm. Traditional methods that rely solely on explicit self-reports are limited because participants can be unwilling to express thoughts or behaviours that they perceive to be socially deviant. In addition, they might not have introspective/conscious access to certain thoughts that can increase their risks of engaging in self-injurious behaviours. Similar impression management problems occur for researchers addressing prejudice and stereotyping, and consequently, implicit tasks that measure automatic biases are of immense value in clinical and social domains. This project will use the Simple Implicit Procedure (SIP) - a highly advanced implicit measure that was developed and validated by the applicant to overcome the limitations in existing implicit measures- to predict those most likely to attempt suicide. The SIP can be used to precisely specify the cognitive mechanisms that are driving an automatic bias, which will offer researchers across a host of domains crucial additional information. This additional insight can be used to assist with the development of interventions aimed at reducing problematic behaviours or thoughts. This project will also use a biopsychosocial approach to determine crucial factors that heighten the risks of suicide, addiction and prejudice. The training I will receive will secure me as the leading figure in advanced implicit measurement, with the necessary infrastructure and international collaborations developed, to establish a lab aimed at providing solutions to major societal problems. Using both front-line pragmatic methods and broad theoretical perspectives to better understand the causes of self-injur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PortalS Of Next Generation' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Portals is a new term, synonymous with access point to resources and services on the Web. Typical services offered by portals include directory of resources, search facility, news, e-mail, phone, map information, and sometimes a community forum. These services generally rely on point-and-click on structured information like characters, still pictures or 2D graphics. The project intends to investigate, develop and standardize the building blocks for the next generation of portals. These building blocks include existing Web technologies, but also 3D computer graphics elements as in computer games, intelligent agents embodied in realistic avatars, new user-friendly interfaces and real-time audiovisual communications. The project will demonstrate how these EW technologies, integrated in a sample e-commerce application, allow an easier and more natural access to resources and services.Objectives:To develop building blocks for the next generation of portals and to demonstrate in a real-time application how they allow a more natural access to services. The building blocks are: 1) shared, dynamic and real-time virtual spaces; 2) Animation of realistic synthetic faces and bodies; 3) Software agents capturing human characteristics and learning user profiles; 4) Intuitive interfaces for navigation and interaction in information spaces; 5) Delivery of information with QoS monitoring.The application is an E-commerce application allowing navigation in synthetic real sites populated with shops. In these sites, users can inspect goods, communicate with virtual or real humans and make transaction.Work description:The project is organized in two areas of work (1) the development of a technology and (2) the development of an application. These two areas are linked by an integration activi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High performance sustainable bio-based packaging with tailored end of life and upcycled secondary use' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

PRESERVE aims at boosting the circular use of bio-based packaging. To shift from the current situation (fossil-based, limited recycling), we build on award-winning upcycling strategies from past and on-going projects. We will enhance the performance of primary food packaging via bio-based barrier coatings for bioplastic and paper/board substrates, as well as via eBeam irradiation and microfibrillar-reinforcement. From the biotechnological side, we will leverage the compounding of enzymes in bioplastics to stimulate biodegradation, the enzymatic recovery of functional oligomers and the delamination of multilayer packaging via enzymatic detergents to enable their layer separation and recycling.The processes required to produce at least 10 packaging demonstrators will be upscaled. The enhanced bio-packaging will be validated with different types of food and drinks. Recovered biopolymers will be upcycled in added value applications such as packaging for personal care products and reusable carrier packaging (using textiles and composites).The versatility of our end of life options, materials, flexible and rigid packaging types and compatibility with different processes, ensure that PRESERVE results are relevant to more than 60% of the plastic packaging on the market, which long term substitution potential will be maximised thanks to the participation of several leading companies in the consortium. Our 2030 roadmap will outline the pathways to significantly influence the emergence of bio-based packaging and create jobs and growth in the sector. To widen PRESERVE impact, we will also perform life cycle and safety assessments, user acceptance studies and contribute to standardisation and certification.All in all, by contributing to the EU Plastics Strategy in a circular economy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Persistent Homology - Images, Data and Maps' under Seventh Framework.

assistant: **Concept**

The main theme of the project is persistent homology in three contexts: digital images, data mining, and dynamical systems. Persistent homology is the most important innovation that has yet emerged from the young field of computational topology. It finds various applications, and in each of them provides new qualities and novel methods.Effective and reliable methods for the analysis of digital images are highly demanded, especially with the increasing technological capabilities of capturing multiple high-resolution images e.g. in medicine. Data mining techniques for acquiring knowledge from huge collections of data, including text documents, are bound to be a new scientific methodology of the future. Dynamical systems appear ubiquitously in modeling of population models, chemical reactions and other processes, and automatic analysis of qualitative properties of the dynamics is of great importance for the understanding of the model.The main objectives of the project are: to use persistent homology for automatic determination of an optimal thresholding level and denoising method for the analysis of digital images; to optimize the existing methods and to develop new algorithms for the persistent homology approach to the analysis of large collections of data, with emphasis on text documents; and to develop new methods and algorithms for applying the persistent homology approach to the analysis of discrete-time dynamical systems induced by continuous maps. In addition to the theoretical basis and algorithms for each of the domains, effective software aimed at specific applications will also be developed.The project involves various branches of mathematics and computer science, from algebraic topology to graph theory, and has trans-disciplinary nature with a wide potential of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms of secretion and extracellular functions of hGBP-1', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The human guanylate binding protein-1 (hGBP-1) characterizes inflammatory cytokine (IC)-activated blood vessel endothelial cells (EC) and regulates the antiangiogenic activity of IC in these cells in vitro and in vivo. In addition, hGBP-1 is the first GTPase which has been observed to be secreted. In colorectal carcinoma, the expression of hGBP-1 in the tumour stroma has been shown in a recent work to be an independent prognostic factor associated with a better outcome. The project focuses on the specific role of hGBP-1 in this context. The objectives of the are: (1) to characterize the mechanisms of hGBP-1 secretion, (2) to study the biological effects of the secreted protein and (3) to investigate the potential in vivo function of secreted hGBP-1. The methodological approach would consist first in the determination of the protein domains responsible of the secretion, to define the non classical secretion pathway involved and to test the association of hGBP-1 with endothelial cells microparticles. Then, the biological effects of extracellular hGBP-1 will be investigated, as well as the existence of a receptor. Finally, the tumours collected in two previous xenotransplant mouse experiments with induced expression and secretion of hGBP-1 will be analyzed for hGBP-1 expression, proliferation and angiogenesis. The long term goal of the project is to exploit the results obtained for new therapeutic applications for the treatment of cancer or infectious diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'From the Sun to stars - Interplay between dynamo and corona' in the context of a Seventh Framework call.

assistant: **Objectives**

Most stars show strong magnetic fields on their surfaces and sustain a hot outer atmosphere, the corona. Two of the fundamental problems in stellar astrophysics are how the stars generate their magnetic field, and how they manage to heat the corona to temperatures of two million K, well in excess of the surface. I will address these problems by performing local and global numerical simulations. These include the stellar interior and an overlaying corona, which are evolved self-consistently by solving the magnetohydrodynamic equations using high performance computing. First results of such novel simulations show that the dynamo benefits substantially from the presence of a corona leading to a stronger amplification of the magnetic field inside the star and that the dynamo can drive dynamic events in the corona. For a more complete understanding of the coupled dynamo-corona system, further steps towards more realistic models have to be taken. The overall goal of the proposed project can be subdivided into three major parts:(1) understand fundamental properties of stellar dynamos using accurate mean-field models of the direct numerical simulations,(2) investigate the influence of the coronal envelope on stellar dynamos and stellar interiors,(3) determine the role of stellar dynamos for the formation and evolution of coronal structures.This study will have a major impact on the fundamental understanding of solar and stellar activity cycles, which is pivotal for interpretation of stellar observations. In particular this concerns the description of the solar and stellar dynamo processes, the formation of space-weather events and the coronal heating mechanisms. Modeling the exact relation between stellar parameters, dynamos in the interior and coronal properties will for the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electrical Starter / Generator disconnect system' under Seventh Framework.

assistant: **Concept**

StaGeDis will establish new conceptual designs for a dual-use starter/generator disconnect system.New generation aircraft require higher level of electrical power, increasing weight and volume of the electrical machines. In order to compensate this increase of weight and volume the generator will be able to operate as an electric starter, eliminating the need of pneumatic starter.Due to safety reasons, the starter/generator requires a disconnection system to protect the machines and engine gearboxThis disconnection system shall be able to separate mechanically the gearbox from the starter/generator with the electrical machine operating whether as starter or generator. This system will be commanded by an electrical pulse.Different technologies and architectures will be studied, evaluated and compared in order to define a proper disconnection system. Criteria of compactness, weight reduction and conformity with harsh aeronautic engine environment will be also an important part of the study.The selected solution will require a detailed design and the definition and methodology of the verification tests.