RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The impact of human aged bone marrow niche on human hematopoietic stem cell function'.

assistant: **Concept**

In humans, aging of the hematopoietic system is associated with anaemia, impaired immune responses and increased frequency of myeloid malignancies. The hematopoietic system is maintained by hematopoietic stem cells (HSCs). HSCs reside in the bone marrow (BM) within specialized niches, where they self-renew and differentiate to produce all blood and immune cells. In the clinical setting of BM transplantation, HSCs from older donors result in a reduced transplantation success, with a worse level of engraftment and higher overall mortality. This demonstrates that there is a reduction in the function of aged human HSCs (hHSCs). Causes of this impaired hHSC function with age still remain unclear. Therefore, it is of great importance to uncover and subsequently target factors that contribute to hHSC aging in order to attenuate impaired haematopoiesis in the elderly. Due to the lack of meaningful human BM (hBM) niche models in the aging field, the current understanding of how extrinsic changes (stemming from the aged hBM niche) contribute to the aging of hHSC is far less advanced compared to the knowledge of the contribution of cell-intrinsic changes. Thus, this proposal focuses on providing a significant understanding of age-associated changes within the hBM niche and their contribution to the aging of hHSCs using an aging-centred hBM niche model. Transplantation of young BM hHSCs into this advanced niche model revealed that an aged hBM niche confers aging on young hHSCs. To this end, the target of the proposal is to address the following questions:(i)How does aging affect the cellular and molecular composition of the hBM niche?(ii)To which extent does an aged hBM niche affect aging of hHSCs?(iii)What are the underlying mechanisms that confer an age-like function on hHSCs?MAN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mitochondrial Strategies in Ferroptotic Cell Death' in the context of a Horizon Europe call.

assistant: **Objectives**

Mitochondria serve as the epicenter of cellular metabolism. Their dynamic communication with other compartments within the cell ensures proper cellular function. My recent work reveals how mitochondria communicate with the plasma membrane (PM) to transport a redox-active lipid Coenzyme Q (Ubiquinone or CoQ). This communication is crucial for inhibiting a form of iron-mediated cell death called ferroptosis. Notably, CoQ is exclusively synthesized within the mitochondria and plays a pivotal role in maintaining the mitochondrial respiratory chain, as well as other metabolic pathways, such as pyrimidine synthesis, fatty acid oxidation and proline metabolism. My work highlights that cellular defense is primarily orchestrated from the mitochondria and surprisingly dependent on a molecule—CoQ—that is indispensable for mitochondrial function. This work shows that mitochondria—known as cell death inducers—protect cells from ferroptosis and opens several key questions that I will address in Mito-FerroQuest, including: i) Which proteins and metabolic pathways within the mitochondria dictate whether CoQ should be exported or retained within the mitochondria? ii) Do mitochondria have other ways to defend against ferroptosis, or is CoQ export their only defense?iii) Does mitochondrial communication extend beyond the PM and involve interactions with other organelles, such as the endoplasmic reticulum (ER), in protecting cells against ferroptosis?Answers to these questions will enhance our understanding of mitochondrial strategies in ferroptosis, potentially paving the way for new therapies in conditions where ferroptosis is implicated, like neurodegenerative disorders. Mito-FerroQuest sets the stage for my overarching goal of exploring ferroptosis in diseases with compromised mitochon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Lidar Emitter and Multispecies greenhouse gases Observation iNstrument' (LEMON) under Horizon 2020.

assistant: **Objectives**

LEMON will provide a new versatile Differential Absorption Lidar (DIAL) sensor concept for greenhouse gases and water vapour measurements from space.During the last climate conference in Paris in December 2015, climate-warning limits have been discussed and agreed upon. In such frame, the need for a European satellite-borne observation capacity to monitor CO2 emissions at global, European and country scales has been identified, as stated by the Copernicus report “Towards European operational observing system monitor fossil CO2 emissions”.New space missions are now being used (GOSAT, AIRS, IASI, …) or planned (OCO, IASI-NG, MicroCarb, MERLIN, …) for CO2 and/or CH4. Given the technical challenges, they are up to now mainly based on passive (high resolution spectrometers) instruments, Lidar instrument-based mission (MERLIN) is currently in development in Europe to probe methane only.Therefore, the main goal of LEMON is to develop a versatile instrument, able to target CO2, CH4 and water vapour stable isotopes (H216O and HDO only, from now on referred to as water vapour or H2O and HDO explicitly) with a single laser emitter.The consortium consists of ONERA (FR), FAUNHOFFER (DE), CNRS (FR), KTH (SE), SPACETECH (DE), UiB (NO), INNOLAS (DE) and L-UP (FR). It has full expertise at Earth Observation technologies (from receiver, data acquisition, instrument control and versatile emitter) and is therefore able to fully explore, understand and validate the aforementioned advantages. The consortium is highly motivated to set-up and perform demonstrations at all instrument levels in order to showcase the project results. This will include the instrument set-up, TRL6 instrument validation, airborne demonstrations and CO2, CH4, H2O isotopes measurements, as well as roadmaps and prelimi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The retinae as windows to the brain: An oscillatory vision' in the context of a Horizon 2020 call.

assistant: **Objectives**

Several sophisticated image processing circuits have been discovered in the animal retina, many of which manifest massive neural synchrony. A major insight is that this type of synchrony often translates to high-frequency activity on a macroscopic level, but electroretinography (ERG) has not been tapped to examine this potential in humans. Bolstered by our compelling results combining ERG with magnetoencephalography (MEG), this project will address several open questions with respect to human visual processing:1) Could variable retinal timing be linked to intrinsic image properties and pass on phase variance downstream to visual cortex? Our data suggests the retina responds to moving gratings and natural imagery with non-phase-locked high gamma oscillations (>65 Hz) just like visual cortex, and that slower ERG potentials exhibit strong phase-locking within stimuli but large phase variance across stimuli.2) Do such retinal gamma band responses, both evoked and induced, directly drive some cortical gamma responses? Pilot data suggests that it can, through retinocortical coherence, our novel ERG-MEG mapping technique.3) Several kinds of motion have now been shown to elicit massive synchrony in mammalian retina circuits. Does this also result in macroscopic high-frequency activity? If so, our experiments will finally reveal and characterize motion detection by the human retina.4) Do efferent pathways to the retina exist in humans? We discovered that the ERG exhibits eyes-closed alpha waves strikingly similar to the classic EEG phenomenon and, leveraging our retinocortical coherence technique, that this activity is likely driven by contralateral occipital cortex. Then, can retinal responses be influenced by ongoing cortical activity?Characterizing retinocortical interaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Implementation of Best Practice of Design Solid-State Power Amplifier for Developing New Generation PET Accelerators' (GreenSSPA) targeting Horizon 2020.

assistant: **Abstract**

According to WHO report, last updated on 2017, the rate of cancer and neurodegenerative diseases (e.g., Dementia, Alzheimer?s, and Parkinson?s disease) is rapidly increasing in both less and more developed countries. They reported that the number of people with Dementia in worldwide is projected to increase to nearly double and a half from 50 million in 2017 to 135.5 million in 2050 and also global cancer rate could increase by 50% to 15 million by 2020. Such reports are alarming scientists to enhance research domains on the diagnostic methods to identify as early as possible to improve levels of treatments. One of the best diagnostic methods for such diseases is to employ Positron Emission Tomography (PET) scanner. The PET scan technology has been under-researched and -developed for many years, and it is still ongoing updating. One of the major components of the PET scanner is cyclotron for accelerating particles. A cyclotron is the most sophisticated part of a PET installation. It makes a strong electric field to accelerate particles, results in radioisotopes. The strong electric field is usually made by a Klystron vacuum tube which is an expensive and immobile part. Hence, in hospital without a cyclotron and far away areas, it is a problem to deliver the radioactive material, as it has a short lifetime, half an hour to few hours and it costs quite a lot to ship the radioactive material by helicopter. In this project, we propose to be used solid-state technology instead of vacuum tube. It will make possible to realise a mobile and affordable cyclotron. Hence, more cyclotrons could be deployed even in remote areas, resulting a cheap and fast treatment. A high impact on both the scientific and industrial communities is predicted from the project. The project is naturall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'External costs discussion group' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The European Commission, through its JOULE Programme ExternE Project, has made substantial contribution to the development of methodologies for the evaluation of the externalities associated with a wide range of fossil, nuclear and renewable fuel cycles. The ExternE project is recognised as being at the forefront of work in this field. However, this is a very rapidly developing area with new data and assessment methodologies continuously becoming available Likewise there is a steadily growing demand for the results of such analysis as they are being incorporated in decision making processes. Hence, it is essential for the researches in this area to keep work up-to-date with new developments and data. The overall objective of this Concerted Action is to set up a Discussion Group to facilitate the exchange of ideas, new developments and information between the large number of European teams now working in the field of external costs. This will enable all teams to keep up-to-date with this fast moving area of research which will be of considerable benefit to their national studies. It is also hoped that the Concerted Action will enable the consistency of approach to the evaluation of external costs within Europe which currently exists to be maintained. This will be very beneficial when the results of such work are employed in European wide activities. It is proposed that the Discussion Group will meet at six-monthly intervals. In addition, more frequent communication between members of the Discussion Group will be enabled by setting up a series of on-line communication facilities using the World Wide Web. The latter will include the publication of a six-monthly Newsletter, organisation of an on-line External Costs Discussion Group and the provision of a file server and arc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BD4NRG: Big Data for Next Generation Energy' to be submitted under Horizon 2020.

assistant: **Abstract**

The rising decentralization of the energy system is unveiling an enormous opportunity for energy stakeholders to leverage on big data & AI technologies to improve decision making. There are however some barriers hampering the exploitation of this potential, such as the lack of standardized big data architectures for smart grids and regulatory frameworks not enabling data sharing. In that respect BD4NRG will i) deliver a reference architecture for Smart Energy, which aligns BDVA SRIA, IDSA and FIWARE architectures, SAREF standard and extend COSMAG specification to enable B2B multi-party data exchange, while providing full interoperability of leading-edge big data technologies with smart grid standards and operational frameworks ii) evolve and upscale a number of TRL 5-6 technology enablers, such as scalable sovereignty-preserving hybrid DLT/off-chain data governance, big data elastic pipeline orchestration, IoT/edge AI-based federated learning and multi-resource sharing tokenized marketplace, loosely integrate and deploy them within the TRL 7-8 BD4NRG framework iii) deliver a TRL8 open modular big data analytic toolbox as front-end for one-stop-shop analytics services development by orchestrating legacy and/or third party assets (data, computing resources, models, algorithms) iv) validate such framework through the delivery of predictive and prescriptive edge AI-based big data analytics on 13 large scale pilots, deployed by different energy stakeholders (TSOs and DSOs power network operators, aggregators, storage/renewable assets operators, local energy communities, ESCOs, power market operators, municipalities, financial institutions and ENTSO-E), fully covering the energy value chain v) setup a vibrant data-driven ecosystem through the SGBDAA Alliance, which will feder
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Induction of targeted CD8+-mediated immunity for the design of epitope vaccines' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

1. Identification of Chlamydia pneumoniae- specific CD8+ T-cell epitopes that elicit a CTL response, for two mouse and two human MHC Class I types (Objective 1;2. Immunization of mice with DNA vaccines coding for specific Chlamydia pneumoniae proteins resulted in partial protection against challenge (Objective 2);3. Several Chlamydia pneumoniae proteins, produced in Bacillus, for use as immunological reagents (Objective 3).PROPOSAL SUMMARY Objectives The overall objective of the proposed research is the establishment of a rationale for the design and development of vaccines to prevent infections by intracellular parasitic agents. To do so will require the identification of mechanisms that optimize the induction of cell-mediated immunity through the targeted activation of specific immune system cells (CD8+), especially cytotoxic T-lymphocytes (CTLs), with as little as possible activation of other immune system cells that may exacerbate the pathology of the infection. The model disease for this study will be infection by the bacterium Chlamydia pneumonia (Cpn), which produces both an acute infection associated with marked inflammatory reactions, and a long-term latent infection in which Cpn persists as an obligatory intracellular parasite, to be studied in a mouse infection model. The separate approaches summarised below, utilising the Cpn mouse infection, are intended to develop a general methodology to both identify and characterize the important CD8+ T-cell epitopes required to induce protective cell-mediated immunity against specific infectious agents, and to optimize this response while minimising harmful immune reactions in the design and construction of effective vaccines heretofore unavailable. Specific Aims and Work Plan The general objective state above will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'understandinG the Role of codon usAge biaS in viruS HOst jumP ProcessEs thRough statistical physics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Assessing the pandemic risk for viruses of zoonotic origin is extremely hard, but its importance motivates a steadily growing interest. The approaches used so far are hindered by the limited knowledge of the complex interactions of viral genomes with human cells. Within the framework of the global research effort to fill this gap, this action aims at unveiling the relevance of specific genomic features, especially those related to the codon usage bias, in the process of viral host jump. Two objectives are established: (i) identify and quantify the host-induced pressures on viral genomes; (ii) use these pressures to quantify the likelihood of host jumps. To address objective (i), the host-induced pressures will be inferred from large public databases of viral genomes, in the spirit of inverse problems in Statistical Physics. The results will be validated through experiments performed in collaboration with an experimental group at Istitut Pasteur (Paris). The results of objective (i) will be used in objective (ii) to take into account the compatibility of the viral genome with the host-induced pressures in a simple model of host jump. The Applicant will benefit from a secondment at University of Basel where he will acquire useful skills for this challenging objective.The ambitious aims of this action will be achieved via a strongly interdisciplinary approach, which will build on the existing skills of the Applicant, who specialized in combinatorial optimization problems and Statistical Physics of disordered systems during his PhD, together with the expertise of the Supervisor on inference and Statistical Physics models applied to biology topics. The proposed project is expected to have practical impact on vaccine strain design and virus surveillance strategies. Moreover,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Researches on the potential conversion of conventional fish farms into organic by establishing a model and good practice guide'.

assistant: **Objectives**

The conversion of conventional aquaculture farms in sustainable aquaculture farms help aquaculture businesses to achieve economic viability and competitiveness. Sustainable aquaculture is undoubtedly the management technique that has most contributed to support aquaculture businesses to adopt aqua-environmental measures for protection of the environment, natural resources and landscape.Aquaponics is known as a sustainable production system for plants and fish that combines traditional aquaculture (aquatic livestock), such as fish, crayfish and shrimp with the hydroponics (growing plants in water) in a symbiotic environment. The Aquaponics is a production system where the waste is utilized as nutrients is a system sustainable for the environment, where high-value products on the market are obtained because they are grown with organic nutrients and free of chemicals or pesticides.By this research project, we aim at to improving onboard waste management and reduce the amount of waste disposed of inappropriately. In order to achieve this goal, we have the following objectives: to integrate aquaculture production system with agricultural production system (aquaponics) and to reconcile and achieve social, economic and environmental objectives with processing and marketing action to add more value to end aquaponics products.The project will develop concepts for the next generation of aquaculture production systems which can be used for multiple purposes, including aquaculture, agriculture and social farming.The project originality comes through its multidisciplinary character in the sense that it combines a research team specialized in various fields, whose experience will result in a production platform product, including all necessary technical indicators for developing and