RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'A total metalworking fluid condition monitoring, optimisation and disposal advisory system'.

assistant: **Concept**

The European engineering sector is worth 3,000 Euro Bn with 375,000 companies, 90% of which are SMEs, providing over 20 million jobs. The sector has been under intense pressure from the Far-East, stifling economic competitiveness through low labour costs. Consequently the number of SME engineering firms has reduced by 20% in the last 5 years. Further pressures have arisen from tightening environmental legislation in the EU. This sector must respond if it is to survive. Over 75% of workshops use water miscible metalworking fluids (MWFs) as an integral part of metal machining.It is has been calculated that about 16% of metal manufacturing costs are attributed to MWFs. About 3,200 million litres of spent MWF are disposed of per annum and if the MWFs are not properly handled they create health concerns for operators (dermatitis/asthma). Currently the engineering sector has a very limited understanding of MWF management, including lifespan and disposal. As IAGs we represent and understand the needs of our large SME membership base. We aim to develop a total MWF monitoring, optimisation & disposal advisory system to extend fluid life by at least double. It will involve the development of innovative MWF concentration & bio-activity sensors plus a sophisticated software algorithm defining the inter-relationships between pH, concentration and bio-activity.The technology will help reduce production costs through reduced fluid purchase & disposal costs. It will also contribute to improved machining, environmental and health & safety performances, compliance with EU environmental legislation and general up-skilling of the large SME engineering family. The combination of innovative RTD providers developing the scientific and technical capability, core SMEs to manufacture the product
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BIOPRINTING BY LIGHT-SHEET LITHOGRAPHY: ENGINEERING COMPLEX TISSUES WITH HIGH RESOLUTION AT HIGH SPEED' in the context of a Horizon 2020 call.

assistant: **Objectives**

Engineered tissues are key elements in both in vitro and in vivo applications, strongly impacting the academy, pharma and clinical sectors. Bioprinting is considered the most promising method to produce such engineered tissues. However, current bioprinting methods are severely limited by both insufficient speed and spatial resolution. Long printing times decrease cell viability, while poor spatial resolution fails to recreate the heterogeneous nature of native tissues. BRIGHTER will develop a new bioprinting technology able to produce tissue surrogates with high spatial resolution at high printing speed using an original top-down lithography approach, in contrast with current bottom-up, layer-by-layer bioprinting methods. BRIGHTER will combine high-speed light-sheet illumination and high-resolution digital photomasks to selectively photocrosslink cell-laden hydrogels in confined voxels and produce three-dimensional complex geometries. This process will enable the bioprinting of key anatomical microfeatures of tissue such as invaginations, evaginations or wavy morphologies. It will also incorporate hollow vascular structures while maintaining tissue mechanical integrity without the need of additional sacrificial material. As a remarkable feature, matrix crosslinking density can be fine-tuned using BRIGHTER’s approach, allowing the fabrication of cellular compartments requiring specific matrix stiffness such as stem cell niches. The proof-of-concept application will be bioprinting viable engineered skin tissues exploiting the key features of the BRIGHTER device: skin appendix (hair follicles, sweat glands), stem cell niches and a vascular network. The ultimate goal is to provide a superior alternative to state-or-the art 3D bioprinting with a disruptive bioprinting techno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Decoding the transcriptomic programs that define human macrophage function.' (MACROCODE).

assistant: **Concept**

Macrophages are essential cells of the innate immune system, playing crucial roles in coordinating inflammatory responses and maintaining homeostasis. In cases of chronic inflammation, damaged tissues release abnormal signals that attract macrophages precursors to the local environment and drive macrophages toward a proinflammatory phenotype. This creates a feedback loop that sustains inflammation. The consequences to society are huge: chronic inflammatory diseases are among the leading causes of death and disability worldwide. Recent single-cell multi-omics studies have identified dysregulated macrophages as central players in chronic inflammation, but the molecular mechanisms sustaining these responses remain poorly understood.MACROCODE aims to unravel the molecular mechanisms governing the altered function of macrophages during chronic inflammation.The specific aims of this project are:1. Use CRISPR-Cas9 technology with single-cell read-outs to perturb genes in macrophages that show dysregulated expression between healthy and diseased states in chronic inflammatory conditions . Genes will be selected by creating an integrated single-cell transcriptomics atlas of macrophages in both health and disease. 2. Develop a computational framework using bioinformatics and AI tools to link these perturbed genes to transcriptomic programs, cellular functions and in vivo disease phenotypes.3. Validate key genes by modulating their expression using dCas9-VPR or KRAB systems, and evaluate the effects on macrophage differentiation, identity and function.Altogether, MACROCODE will decode the genetic regulation of macrophage dysfunction in chronic inflammation. This multidisciplinary project will equip me with advanced skills in genomics and bioinformatics, enhance my leadership and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Probabilistic Performance Based Durability Design of Concrete Structures'.

assistant: **Concept**

BE95-1347 Probabilistic Performance Based Durability Design of Concrete Structures With the present design approach with respect to the durability of concrete the building industry is hardly able to compete. Possibilities for competition on basis of durability with other designs of structures made of concrete or other structural materials, such as steel, timber or masonry is extremely limited. The consortium for the proposed research is convinced that a performance based design provides this option, as it uses realistic environmental and material models capable to predict the future behaviour of a concrete structure and hence quantifies the design life. The present design approach with respect to durability of concrete structures is for a large extent empirical. It is based on deem-to-satisfy rules (e.g. minimum cover, maximum water/cement ratio) and the assumption that if these rules are met, then the structure will achieve an acceptably long but unspecified life. Improving the durability may result in increasing building costs but cannot, but current design methods do not permit the whole life cycle costs to be defined. There is thus no means for demonstrating that future maintenance and repair costs will reduce. The result of the project will be design methodology with the following benefits: - durability design will be based in the same principles as structural design (safety, serviceability, limit states and reliability) -design based on the total life cycle costs will be possible -a reduction of the consumption of materials and energy by optimal use of the materials -objective basis for consultants, contractors and maintainers to make tailor made designs, especially if the design is based on industry specific material properties -realistic performance test procedu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Open Innovation Test Bed for Electrolysis Materials for Clean Hydrogen Production' (CLEANHYPRO), addressing dissemination and exploitation.

assistant: **Impact**

CLEANHYPRO gathers some of the most recognised experts in Europe on the electrolysis field for clean hydrogen production and acknowledged facilitators of technology transfer, corporate finance, funding and coaching, making available (i) the most promising and breakthrough manufacturing pilots and (ii) advanced characterization techniques and modelling together with (iii) non-technical services through this Test Bed: while relevant improvement metrics can be defined, the potential network of reachable stakeholders counts thousands of businesses on an international scale. Key facts are reported below. Within the scope of CLEANHYPRO, several circular innovative materials and key components, four main electrolysis technologies and geometries will be covered, providing for the first time a single entry point for industrial partners, mainly SMEs, aspiring to answer their concerns but with minimum investment costs and reduction of risks associated with technology transfer, while opening-up opportunities for demonstration of materials and components (TRL7) and thus faster opening the market for these new products. The main KPIs for CLEANHYPRO: Technical: >20% cell productivity improvement, 30% faster verification, 27-58% and 22-79% cost reduction of technologies in CAPEX and OPEX respectively, 3-9% efficiency enhancement. Non-Technical: 4 Showcases, 4 certification schemes, ≥16 Democases, >100 reachable SMEs and > 300 reachable investors. INNOMEM stems from the consideration that the development of products based on key materials and components for electrolysis require access to finance and an optimised business planning, relying on a sound prior analysis of the market, of the economic impacts and capacity of a company. The project aims at developing and organizing a sustainabl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Industrial symbiosis for valorising whey and banana wastes and by-products for the production of novel foods' under Horizon 2020.

assistant: **Concept**

It is more efficient to maximise the value of food waste and by-products than reducing the cost of its management and disposal. Applications in this direction require intersectoral and intrasectoral synergies for maximising utilisation of complementary waste resources and multidisciplinary approach to research innovation and skills. SYBAWHEY aims a trans-national partnership between Europe and Africa for promoting area-wide sustainable supply network for the generation of innovations in the direction of food waste management and valorisation. The main focus will be on exchange of material (waste and by-products) and non-material based resources (knowledge and transferable skills) via international as well as intersectoral mobility between Africa and Europe. Methodologically, it draws on a case study of high volumes of underused by-products and wastes from banana production in Uganda and the environmentally toxic cheese whey produced by Cyprus dairies. Compared to other regions, whey from Cypriot dairies presents high lactose content and therefore great potential for product-driven biorefining. Moreover, banana flavour is one of the most preferred flavours in dairy products. SYBAWHEY aims a multidisciplinary approach to the network including assessing the feasibility and impact of whey and banana waste and by-product valorisation into useful products with high input to the same or different industrial plants; development of innovative technologies for aroma extraction from banana pulp and peel to be used in dairy products; characterisation of whey and banana pulp and peel and development of bioprocesses for their utilisation in health-promoting fermented whey-based novel foods; assessing the sustainability of banana flour in terms of energy and resource use as well as as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a novel and integrated portable non destructive analysis system for the documentation of artworks.' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The scope of the project is the development of an integrated non-destructive portable analysis-diagnosis system (called InfrArtSonic) for the 3D sampling and reconstruction of painted artworks. The system will be of a unique and invaluable aid for art hist orians and restorers in the frame of documentation of cultural object in the Mediterranean area. The system will unify different modalities such as 3D ultrasound microscopy, VIS-nIR-mIR spectroscopy and digital imaging. Using data fusion methods the system will be able to display the depth profile of the paint layers of an artwork as well as the local distribution of the pigments in each of these paint layers. In brief: 1.The InfrArtSonic system will constitute a powerful non-destructive documentation tool for artworks. The system will provide with: 2. The overview of the stratigraphy without sampling. 3. Possible previous overpaintings as well as the reveal of previous restoration attempts. 4. The authenticity of the artwork. 5. The painting technique and m aterials used. The methods that will be used and optimized taking into consideration several special aspects of the present proposal for the acquisition of the needed and relevant information are 1. Acoustic microscopy. 2. VIS-nIR-mIR Spectroscopy and nIR-mIR imaging. Special methods will be developed in order to fuse all the available information and thus maximize the benefit obtained by the information that is provided from each of these methods. As soon as a definite and exact result is derived from the fusion of the data, a 3D model will be used in order to display the results in a user friendly visual way. Using acoustic microscopy the depth profile of the paint layers? is definitely possible. Using VIS-nIR-mIR spectroscopy the local distribution of th e mate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Improving loan quality and acceptance rates by predicting credit behavior through social media data.'.

assistant: **Concept**

The problem:  Credit Losses on Banks’ Loan Portfolios - Youngsters and 2nd generation immigrants still have difficulty in obtaining credit.The solution: Our credit scoring model called Big Data Score assesses the credit quality of people and accurately predicts their payment behaviour based on data from social media (Facebook) and internet browsing behaviour. Objectives of the overall innovation project: 1)Bring the present Technology Readiness from level 7 to 9.2)Provide the system with complete access to real life data and Open Data made available from governments.3)Development of a marketing and sales strategy based on two key principle: vertical approach and distribution approach.Value Proposition: To help lenders to save money on credit losses and to make more money on increased acceptance rate.Business Model:  Business follows a simple and easily scalable model where lender pays for each score: 0.99 EUR per Facebook score and  0.20 EUR per browser score.Users/Clients: Our target client is anyone who is taking a short to medium term (1-36 months) credit risk.Competition: Traditional credit bureaus and innovative credit score (Kreditech, Leendo, ZestFinance).Revenue Streams: 36M€ revenues at the 3rd year after commercialization.Team: Big Data Scoring AS, Aasa Global AS.Required funding: 1,5M€
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Triloci-seq - Dechipering the triple helix code' (2014-2020).

assistant: **Concept**

Recent technological advances revealed that there are many long non (protein)-coding RNA molecules (lncRNA) transcribed in the genome, many of whom regulate gene expression. However, it remains unclear how lncRNA molecule can interact directly with chromatin to regulate gene expression. One possibility that has been raised is via the formation of triple-helices. The potential for the formation of triple helices exists in any nucleic acid chain via an interaction called Hoogsteen base-pairing.  However, unlike the genetic code or even Watson-Creek base-pairing, the triplex code or sequences which can function as triplex target sites and triplex-forming oligos is poorly understood. To decipher the triplex code in vivo, I propose a novel research approach based on next generation sequencing that I call Triloc-seq (in vivo). The feasibility this research plan relies on two crucial resources: first, mammalian genomes which can harbor as many as hundreds of thousands of putative high-affinity triplex target sites (TTSs), and second mixed-base oligo synthesis technology. Together these resources will allow us to over-come the greatest obstacle in triplex study, the need to match specifically a target site with its triplx forming oligo (TFO). To study the triple-helix code,  we will transfect mammalian cells with a TFO libraries, and use click chemistry to join the TFO to its target site. We will then use previous TFO-TTS data obtained in vitro and multiple advanced bioinformatic approaches to extract the genomic TTSs. Finally, to prove that triplex interaction can be functional in vivo, we will design several applications that will test this functionality. In all cases we will design a cassette of known TTS target sites and position it upstream of a minimal promoter. The TTS c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genes, environment and immunity in the pathogenesis of rheumatoid arthritis' (PREVENTRA) targeting Seventh Framework.

assistant: **Abstract**

Aims and significance: The aims of this program are (1) To obtain new understanding of how environmental and life style factors interact with genes to induce immune reactions able to cause the different forms of arthritis that are defined as RA; (2) To use this understanding to develop prevention and targeted therapy for different forms of RA, and to enable efficient and eventually curative therapy. Background: We build on new understanding or RA etiology that has followed from studies on interactions between genes, environment and immunity in different subsets of RA. This has been provided for new detailed studies on specific and eventually disease-inducing autoimmunity in RA. Research program: We will use our infrastructure (longitudinal large cohorts, biobanks genetic information and our molecular immunology laboratory) to investigate (1) how genes and environment interact in causing different forms of RA; (2) how specific immune reactions against post-translationally modified (mainly citrullinated) autoantigens are triggered by environmental agents in specific genetic contexts in different individuals; (3) How these immune reactions target different organs (joints, lungs etc) and eventually cause arthritis in model systems; (4) how the combination of genes, environment and immunity may determine disease course and response to various therapies. Novelty and opportunities to take knowledge of autoimmune disease and RA to a new level: The recent advances in understanding interactions between genes, environment and immunity in RA, provides a striking new opportunity to understand basic features of autoimmunity and autoimmune disease, as well as potentials to prevent and treat RA very early. I believe that the presented program is well positioned to use this opportunity