RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A novel, efficient and minimally invasive medical procedure to treat anastomotic leakage during colorectal cancer surgery.'.

assistant: **Concept**

It is estimated that in 2018, 97,220 people will be diagnosed with colorectal cancer and that about 50,630 people will die from this disease; making treatment this cancer to be of growing importance nowadays. Despite improvements in the area of surgical treatment of the tumor, there are still many risk factors connected with mortality, recovery and reoccurrence rates, as well as complications (like anastomotic leakage). After having successfully launched an innovation that permits the transport of Ebola patients in 2014, Tecnoline (a medical company founded in 1992 in Modena, Italy) decided to invest into innovation development for the surgical treatment of colorectal cancer. Three years ago the team started developing a prototype of the Catheter for Transcaecal Ileostomy (CTI), an alternative technique to loop ileostomy to defunction low rectal anastomoses. Our company conducted a positive round of animal and clinical tests. The new invention is capable to decrease morbidity and mortality rates due to anastomotic leakage and surgery complications; diminish the hospital stay and ‘worried well’ by 50%; reduce the operating time by at least 50% and up to 99% leakage of feces. It also have a positive environmental impact since it replace the disposable plastic pouches and reduce energy use and other impacts connected with the patients stay in the hospitals. Finally, this invention has the potential to boost the company growth, translated into 8.91M€ of turnover (2025) and 40 new hires for the development period. Tecnoline was authorized by the Ethical Committee of Aragon (Spain) to implement CTI in a patient population in Aragon (18 patients). The solution has just passed through the experimental process and therefore reaches TRL7. Thus, it is the right moment to start pre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The artificial pancreas in children aged 1 to 7 years with type 1 diabetes' (KidsAP), addressing dissemination and exploitation.

assistant: **Impact**

TYPE 1 DIABETES is one of the most COMMON CHRONIC diseases in children with a RAPID increase in number of cases particularly in young children. Type 1 diabetes is associated with LIFE-LONG dependency on insulin administration. POOR glucose control leads to diabetes COMPLICATIONS, e.g. eye, heart, kidney disease, including BRAIN changes in young children. Episodes of VERY LOW glucose levels may be life threatening and are a major complication. The ARTIFICIAL PANCREAS addresses the problem of LOW and HIGH glucose levels by delivering insulin BELOW and ABOVE pre-set amounts according to real-time sensor GLUCOSE levels, combining glucose SENSOR, insulin PUMP, and CONTROL ALGORITHM. The Artificial pancreas promises to TRANSFORM management of type 1 diabetes but EVIDENCE supporting its use during FREE LIVING in YOUNG CHILDREN is MISSING.The project evaluates the biomedical, psychosocial, and cost effectiveness of NOVEL INDIVIDUALISED artificial pancreas in young children aged 1 to 7 years with type 1 diabetes. Following a PILOT (n=24), in the MAIN study (n=94) half of the participants (n=47) will be treated over 12 MONTHS by the ARTIFICIAL PANCREAS and the other half (n=47) by STATE-OF-THE-ART PREDICTIVE LOW GLUCOSE MANAGEMENT insulin pump therapy. Each treatment will last ONE YEAR. QUALITY OF LIFE will be assessed and semi-structured INTERVIEWS conducted to understand the impact on daily life. HEALTH TECHNOLOGY ASSESSMENT will support reimbursement. The project will OPTIMISE artificial pancreas and SPEARHEAD SYSTEM-WIDE improvements in health care quality and health outcomes in YOUNG CHILDERN with TYPE 1 DIABETES who live with the disease LONGEST. By IMPROVING THERAPEUTIC OUTCOMES, the project will CHANGE clinical practice and INFLUENCE national and international treatment g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BIG DATA using SECOND SCREEN AND CONTENT RECOGNITION (BDuSSCR)' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

TV Viewers demand a personalized and richer experience while watching TV. Broadcast TV and producers try to develop interactive products to build a stronger engagement with their audiences. Advertisers are tired of ad strategies that are not measurable nor results‐oriented. Most of the broadcasting agents (TV/radio broadcasters, content producers, advertisers and their agencies) have poor information about the current behavior of their audiences. To improve the quality of such information they need to incorporate, on a personalized way, Big Data tools that help develop new strategies into their business activities.Bridge Mediatech, S.L. (from now on BMT), a Spanish technology company, has developed a Cloud-based Platform embedding its patented Automatic Content Recognition (ACR) technology in order to provide a richer experience to the audience. It also provides the broadcasting players with an easy to “install and operate” Big Data Platform to improve the engagement with their audience. It helps getting to know them better and it allows to offer customized contents tailored to their needs product and services.After having proved the core of the technology in the world´s largest Spanish speaking broadcasting player like Televisa, it´s time to start thinking about large scale solution deployment and international expansion. For that reason BMT applies to this call to develop the Feasibility study needed to accomplish the technology consolidation and large scale deployment which will let BMT become the global leader in this emerging and innovative marketplace
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MAL: an actin-regulated SRF transcriptional coactivator' in the context of a Seventh Framework call.

assistant: **Objectives**

MAL: an actin-regulated SRF transcriptional coactivatorRecent years have seen a revitalised interest in the role of actin in nuclear processes, but the molecular mechanisms involved remain largely unexplored. We will elucidate the molecular basis for the actin-based control of the SRF transcriptional coactivator, MAL. SRF controls transcription through two families of coactivators, the actin-binding MRTFs (MAL, Mkl2), which couple its activity to cytoskeletal dynamics, and the ERK-regulated TCFs (Elk-1, SAP-1, Net). MAL subcellular localisation and transcriptional activity responds to signal-induced changes in G-actin concentration, which are sensed by its actin-binding N-terminal RPEL domain. Members of a second family of RPEL proteins, the Phactrs, also exhibit actin-regulated nucleocytoplasmic shuttling. The proposal addresses the following novel features of actin biology:¿Actin as a transcriptional regulator¿Actin as a signalling molecule¿Actin-binding proteins as targets for regulation by actin, rather than regulators of actin functionWe will analyse the sequences and proteins involved in actin-regulated nucleocytoplasmic shuttling, using structural biology and biochemistry to analyse its control by changes in actin-RPEL domain interactions. We will characterise the dynamics of shuttling, and develop reporters for changes in actin-MAL interaction for analysis of pathway activation in vivo. We will identify genes controlling MAL itself, and the balance between the nuclear and cytoplasmic actin pools. The mechanism by which actin represses transcriptional activation by MAL in the nucleus, and its relation to MAL phosphorylation, will be elucidated. Finally, we will map MRTF and TCF cofactor recruitment to SRF targets on a genome-wide scale, and identify the steps in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'NEW GENERATION OF HIGH VALUE-ADDED ANTIOXIDANT FOOD INGREDIENTS FOR THE GOURMET CUISINE'.

assistant: **Innovation**

In recent years, we have been witnessing a boom of gastronomic themes and a constant and continuous emergence of new and sophisticated food products in contrast with the simplicity of the traditional cuisine. There are around 2,000 Michelin Star restaurants and more than 20,000 high standing restaurants all over the world. The competitiveness in this sector is very high and there is a necessity of differentiation from the competence, looking for new flavours, aromas and textures that allow their dishes to have high value-added.VINESENTI is a natural product obtained from the valorisation of grape pomace, a winery by-product. It is a concentrate reddish or ochre powder, depending on the grapes that it comes from, red or white grapes. It has been designed to enhance and enrich recipes because of its benefits related to improvements in the sensory profile, textures and shelf life of dishes. Specifically, this product provides freshness, spiced flavours, sweet tannins and fruity sensations. The main objectives of the Phase 1 of SME Instrument are to study, evaluate and redefine, if necessary, the different factors of VINESENTI project in order to carry out the Phase 2 successfully. To achieve these objectives, Abro Biotec will carry out a feasibility study which could be divided into the following tasks: a technical study, a market analysis and customer discovery, an economic study and the IPR strategy and legal issues.VINESENTI will suppose a new niche market for the company because up to now, pharmaceutical and cosmetic industries have been the main end-users of the grape polyphenolic extract; but in the future, restaurants, food companies and people in general will be a new market segment. In consequence, a growth of the company will be achieved and this will result in a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Magnetic movement valve for miller cycle operation of engines - reducing nox, co2 and particulate emission' (MAGMOVE).

assistant: **Concept**

This project is designed to develop the prototype magnetically operated secondary inlet valve The valve added to existing cylinder heads can improve combustion and emission control in gas and diesel truck engines and in smaller higher revving engines. The valve lift and timing are completely free controllable throughout the cycle, independent of the mechanical drive. The valve is a practical adaptation of both throttle free load control and the Miller Cycle. This project takes the prototype design of the magnetically operated secondary inlet valve and creates design tools to allow pre production valves to be developed. Wave and CFD design tools will be used, optimised valves made and validated. Reduced CO2, particle- and NOx emissions are possible to EuroV and better. The design tool when validated to 2000 rpm will then be used to develop the valves for 4000 and 6000 rpm. Wear tests will be simulated and materials evaluated for reliability and life.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bounding Nuclear Exceptionalism' in the context of a Horizon 2020 call.

assistant: **Objectives**

The demise of the Intermediate-Range Nuclear Forces Treaty in 2019 has rendered it impossible for Europeans to know whether the missiles that may fly over their territories carry a nuclear payload or not. This development has brought the question of the entanglement between the nuclear and the non-nuclear world to the forefront of international security. Existing scholarship, however, has operated under an assumption of nuclear exceptionalism, treating nuclear weapons as special and different. In response, nuclear and conventional scholars have each crafted their own fields of study, with their own theories and without much interaction between them. The assumption of nuclear exceptionalism has thus blinded scholars to the question of entanglement. In BNE, I will offer a diagnostic of the problem and formulate proposals to move scholarship beyond this blind spot. To that end, I ask the following question: How do the practices of nuclear exceptionalism shape nuclear weapons policy options? To address it, I first identify scholarly practices of nuclear exceptionalism. I then examine the effects of the assumption of nuclear exceptionalism on international policy through two novel case studies: (1) the development of tactical nuclear weapons in the United States and France in the 1980s and (2) the successes and limits of disarmament movements as compared to other large social movements from the 1980s to the present. Lastly, I propose avenues for re-embedding nuclear scholarship within the broader study of international politics. By bridging the gap between the nuclear and non-nuclear realm, this project allows us to understand how and why countries make certain choices in constructing their military arsenals and reflect upon ways to disrupt the new arms race. Beyond producin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular Mechanisms for Construction of Protective Mucus Hydrogels' (2021-2027).

assistant: **Innovation**

Our bodies produce copious mucus daily to shield vulnerable epithelial cell surfaces in the lungs, intestines, and other organs. Mucus is crucial for defense against pathogens and other environmental hazards, but the mechanisms by which mucus hydrogels assemble and execute their functions are poorly understood. The main obstacle has been that the enormous, heavily glycosylated, and flexible mucin proteins constituting mucus are not readily amenable to structural and molecular approaches. However, I contend that mucin glycoproteins have exquisitely specific abilities and interactions that are ultimately understandable on the molecular level. By carrying out the research plan described herein, we will crack the code that transforms the primary building blocks of mucins into diverse three-dimensional, dynamic, and active hydrogels. Specifically, we will test the hypothesis that glycosylated mucin regions are tunable entropic spacers that influence the positioning and adhesion of neighboring folded domains, thereby controlling mucin assembly and hydrogel formation. We will solve the first high-resolution structures of respiratory mucins and will develop an experimental and theoretical framework for analyzing the spans and dynamics of O-glycosylated mucin domains. Perhaps most exciting is our recent discovery that the redox set-point of the Golgi apparatus influences sialic acid decoration of O-glycans during mucus biosynthesis, with potential implications for mucus biophysics and viral penetration. We will explore the benefits of this regulatory pathway for mucin self-assembly, hydrogel properties, and mucus barrier function. Together, this work will pave the way toward rationally manipulating mucus hydrogels, offering new avenues for the treatment of inflammatory, fibrotic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Electromigration monitoring equipment assessment' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

- To reduce test time in electromigration tests targeting low current 0.1 mA/cm{2}, more appropriate to real life, and to perform very accurate measurement of resistance degradation at a very accurately held temperature (sigma = 0.0085 °C) to obtain credible results in about 10 days, and low costs per DuT (Device under Test).- To establish a new standard for electromigration testing with reduced test time using in-situ degradation monitoring, opening up a whole new family of reliability systems using the same principles.The assessment of the DESTIN electromigration test system will be carried out by three semiconductor manufacturers. Normally high currents have been used to speed up electromigration test results but correlation with real-time results is poor. Here the approach is very accurate measurement of degradation resistance changed at low stress currents to give better correlation with real-time.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A single-cell atlas of human soft tissue sarcoma ecosystems with focus on mechanisms of immune evasion', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Soft tissue sarcomas (STS) are rare, aggressive cancers. About 50% of patients with high-risk STS die within 5 years after diagnosis, highlighting the need for novel treatment approaches. A major obstacle for novel treatment design is our limited understanding of STS as ecosystems, shaped by diverse tumor cells and their interactions with cells of the microenvironment. Emerging strategies that target cellular relationships in STS are promising, such as immune checkpoint inhibition. First clinical trials assessing immune checkpoint inhibition were promising, but success varied greatly among different STS subtypes and a rational selection of patients was not available. A comprehensive description of the complex cellular diversity and interactions in STS tumor ecosystems and links to disease progression are currently missing. Here we will combine simultaneous detection of single-cell transcriptomes and cell surface proteins with 32-plex immunofluorescence imaging to characterize STS tumor and immune cell diversity with single-cell spatial resolution in seven STS subtypes. The STS subtypes include dedifferentiated liposarcoma, Ewing sarcoma, myxoid/round cell liposarcoma, clear cell sarcoma, desmoplastic small round cell tumor, fibromyxoid sarcoma, and solitary fibrous tumor, present with poor prognosis and are promising candidates for immunotherapies. Objectives are (1) to characterize the cellular diversity and tumor-immune interactions in STS ecosystems using simultaneous single-cell transcriptomics and cell surface proteomics, (2) to profile the STS immunoenvironment with single-cell spatial resolution in situ, and (3) to functionally assess candidate tumor-immune interactions in vitro. This project will provide the first single-cell atlas for seven STS subtypes and wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Field opErational teSts supporT Action' under Seventh Framework.

assistant: **Concept**

The FESTA Support Action is a vital step in the realisation of scientifically robust and efficiently run Field Operational Tests which aim to evaluate key ICT functions. A consortium of European experts with a wide range of skills has been formed to allow the development of a best-practise" handbook which will guide the design and implementation of an FOT. The consortium involves the participation of academic institutes and national research laboratories, vehicle manufacturers and system providers, along with representatives of national road authorities. This allows the dovetailing of scientific integrity and practical considerations. This Support Action will consider the whole lifecycle of an FOT, from the analysis of stakeholders' needs, the choice of behavioural and other (performance and individual) indicators, the methods by which they are measured (data acquisition), and analysed, reported and integrated and legal, ethical and procedural considerations. In addition, a whole range of ICT functions will be considered, ranging from vehicle systems (e.g. collision warning systems), cooperative systems (e.g. traffic management systems) and nomadic devices such as driver information systems. Running alongside the standard management functions, will be the development of two key workshops to involve wider participation of stakeholders. They will provide the opportunity to undertake needs analyses and dissemination activities. The potential for exploitation of the results and outputs of the FESTA Support Action are high, given the specific EC call for FOTs in the near future."