RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Brain-Chip Interface for High-resolution Bi-directional Communication' (CyberRat).

assistant: **Innovation**

We intend to create an innovative interface between a semiconductor chip or an ensemble of semiconductor chips and the brain of a living rat. Small CMOS chips featuring stimulation and recording sites integrated at high-density (1000 elements spaced only 5-10 micrometers) will be implanted in several brain areas, either independently or simultaneously, thus obtaining an unprecedented control of neuronal activity in the mammalian brain. Thanks to high-density integration, functional electrical imaging and stimulation of neuronal networks within the brain cortex and deep nuclei will be performed at a spatial resolution close to the single neuron and at a temporal resolution of a few tens of microseconds. Obtaining such high spatiotemporal resolution will enable for the first time to explore and control brain information processing with unprecedented detail. The project will focus on sensory-motor circuits regulating coordinated voluntary movement. By exploring interfacing with the main cortical and nuclear structures of the brain, the choice of this neurobiological context ensures that the approach will have a general applicability to several other brain circuits such as those underlying vision, hearing and attention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Small animal proton Irradiator for Research in Molecular Image-guided radiation-Oncology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Precision small animal radiotherapy (RT) research is a young emerging field aiming at unravelling complex in-vivo mechanisms of radiation damage in target and non-target tissues, for translation into improved clinical treatment strategies.For commonly used X-rays, commercial small animal radiation research platforms were recently developed to provide precision imaged-guided RT comparable to state-of-the-art human treatment. Conversely, such platforms are not yet existing for proton beams, which are increasingly used in RT due to their superior ability to concentrate beam energy in the tumour and spare normal tissue. Pre-clinical research is thus carried out at the few available proton therapy facilities, lacking adequate beam quality and image-guidance for small animal treatment. To fill this gap, this project will realize and demonstrate the first prototype system for precision small animal proton irradiation at existing experimental beamlines of clinical facilities. Improved beam quality for targeting small structures will be achieved via a dedicated magnetic focusing system. Innovative in-situ image-guidance will combine ion-specific solutions of proton-transmission imaging (for treatment planning) and thermoacoustics (for verification of the beam range) with established ultrasound (for real-time morphological confirmation) and positron-emission-tomography (for functional assessment). The resulting multi-modal “sight” will be used to foster new workflows of treatment adaptation. The system will be thoroughly tested and finally deployed in a first in-vivo study in different orthotopic mouse cancer models, in comparison to reference X-ray RT at a commercial small animal platform. SIRMIO will deliver the first, compact and cost-effective precision small animal proton ir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Leading the way to energy autonomous edge computing' in the context of a Horizon Europe call.

assistant: **Objectives**

The number of internet of things (IoT) nodes is exploding and is expected to reach trillions by 2035. The biggest logistical challenge of an IoT device is its finite battery life. In response, we develop disruptive ultra-low power semiconductor technologies. Our energy harvesters allow IoT devices to use ambient energy (solar, thermal, vibration, radio) to recharge batteries while our sensing solutions and our microcontrollers optimize/reduce the energy consumption. This enables designers to substantially reduce IoT device battery requirements while eliminating the labour costs of replacing and environmental hazard of disposing of used batteries. With EIC support, we will deliver/industrialize the World's first integrated IoT platform uniquely combining energy harvesting, edge computing and computer vision with ultra-low-power consumption. This will position e-peas as a European based global leader to address the imminent needs of energy autonomous IoT and edge-computing devices.


**Keywords:** Environmental and Green Technologies,Internet of Things, embedded, pervasive systems,Network infrastructures,Energy Efficiency,Micro (system) engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative High-performance Motion Simulation System For Entertainment, Research And Training Applications' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This project intends to develop a highly efficient vehicle motion simulator for entertainment, research and drivers training applications. It will fill the gap between existing low cost static simulators and the expensive motion-based driving simulators by the introduction of a new concept of motion generator platform. The main objective of the project is the use of a 4-DOF spherical platform as motion base in combination with highly efficient video and audio systems.Objectives:This project covers the gap existing between low cost static simulators and the expensive moving-base driving simulators, by the introduction of a new concept of motion generator platform. The main objective of this project is the use of a 4-DOF spherical platform as motion base in simulators, in combination with highly efficient video and audio systems. This spherical platform is much simpler than traditional systems and furthermore, with this platform the fidelity in the motion simulation is much better that with other systems. In addition, the mechanical complexity and also the actuators driving energy is smaller than in traditional systems. The motion platform architecture to be used in this project is based on recent studies on human motion perception and simulators configurations.Work description:The system to be developed in this project is formed by:.A 4-DOF spherical motion platform.A driving post compatible with the motion platform and the specific application..A suitable image/sound generation system.Different virtual scenarios for system operationThe four basic fields of application of SIMUSYS are:.Entertainment/amusement market, home use or public establishments. In public establishments, the system will be configured as a coin-operated device. It is foreseen to achieve compatibility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Non-invasive follow-up of urinary tract cancers' (ENSURE).

assistant: **Innovation**

Bladder cancer is the most common malignancy of the urinary tract with 573,000 new cases and 213,000 deaths in 2020 worldwide and affecting more men than women in a 4:1 ratio. Bladder cancer has the highest lifetime treatment costs per patient of all cancers, which is mainly attributed to the intensive follow-up procedures of patients after diagnostics and surgery. Follow-up is made recurring to extremely invasive and low-patient compliant tests. ENSURE aims to validate the technological and business feasibility of the electronic nose technology developed in the ERC Starting Grant SCENT by establishing the proof-of-concept for the non-invasive follow-up of bladder cancer patients. To accomplish this, we will approach the project from both Technical and Business perspectives, with a perfect synergy between the research and business teams, and a close contact with clinical collaborators and stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'NEW TRENDS IN ENERGY DEMAND MODELING' (NEWTRENDS).

assistant: **Innovation**

The EU 2050 Long-term Strategy develops scenarios for a climate-neutral EU in 2050 that aim at full deployment of low-carbon technologies or assume increased climate awareness of EU citizens translating into lifestyle changes, consumer choices, and a more circular economy. While these scenarios integrate societal trends, further progress is necessary to enhance the empirical basis for such New Societal Trends and their representation in models. New Societal Trends have potentially a large (increasing or decreasing) impact on energy consumption and might lead to cross-sectoral demand shifts that go beyond extrapolation of presently observed trends (continuous trends) and may speed up when they are embraced by larger parts of the society (disruptive trends). Such trends include in particular: digitalisation of the economy and of private lives, Circular Economy and Low-carbon industry, and Shared Economy, which will be the main focus of the present project.The novelty of our project arises from three perspectives:A thematic perspective identifying and quantifying how New Societal Trends affect energy demand, using trend-evolution pathways.A methodological perspective combining qualitative (foresight methods) with quantitative cross-sectoral modelling and exploring how energy demand models are to be improved to represent New Societal Trends. Several well-established models build the core of this project (INVERT/EE-Lab, FORECAST bottom-up model family, PRIMES energy system model, GEM-E3(-FIT)). All of which have been used extensively in the EU context for long-term projections and will be enhanced in this project. Further, policies will be represented in the demand models that influence such trends in the light of the EE1 Principle. Finally, a data perspective enhancing the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '“Chromatin Re-organization during Shade Avoidance”' in the context of a Horizon 2020 call.

assistant: **Objectives**

Plants are sessile photosynthetic organisms, which adapt their growth and development according to their light environment. The reduction in red/far-red ratio (low R/FR), caused by absorption of red light and reflection of far-red radiation by canopy leaves, signals the proximity of neighboring plants and triggers the shade avoidance syndrome (SAS). The SAS consists in large changes in plant body form, in particular rapid elongation of selected organs providing enhanced access to sunlight. Shade-induced elongation is triggered by a rapid and transient burst in the production of the phyto-hormone auxin (IAA). However, elongation growth persists way beyond the initial increase in IAA levels and it is currently not understood how this initial signal leads to long-term growth. This project aims to identify epigenetic reprogramming events caused by reduction in R/FR and the pulse of IAA production, to allow a rapid and persistent growth response in Arabidopsis thaliana. The chromatin state of shade-grown seedlings will be analyzed by combining two novel approaches: INTACT nuclei purification and ATAC-sequencing providing information about chromatin accessibility. This data will be integrated with genome-wide expression and transcription factor binding sites enabling us to relate transcription factor binding, chromatin state and gene expression. The relevance of shade-induced changes in chromatin modification will be tested functionally by mutational analyses. This project will provide important information about the regulation of gene expression by changes in the environment and how these are mediated by hormonal cues and light-regulated chromatin organization. More broadly, understanding the response to shade has an agricultural relevance. Crops grown at high density displa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Versatile Integrated Brillouin-Kerr Frequency Combs for On-Chip Photonic Systems' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

An ultra-stable, low-noise optical frequency comb seamlessly integrated into a compact chip-scale form factor has the potential to revolutionize precision measurements, radiofrequency and optical communications, and quantum technologies.  Today’s chip-scale frequency combs can achieve stable, phase-locked and broadband emission, but they suffer from high noise that blocks the pathway towards more stringent applications such as microwave photonics.  Brillouin optomechanics, a nonlinear optical effect relying on coherent coupling of photons and acoustic phonons, can enable on-chip lasers with ultra-low noise and high purity.  My ERC Proof of Concept project Veritas will build on initial breakthroughs of harnessing Brillouin optomechanics in silicon nitride and aim to deliver the first chip-scale low-noise frequency combs. I will explore system applications of these combs for agile frequency conversion in 6G radio systems and for coherent optical communications.  Along with these technological developments, I will perform a thorough market study with appropriate IP measures, maximizing the commercial potential of this technology. We expect that our results in Veritas will point to the feasibility of this technology for software-defined reconfigurable front-ends for very high frequency and size and weight-sensitive RF applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Analysis of the mechanisms of th e early brain pattterning - study of pax-3 and pax-6 function in transgenic mice'.

assistant: **Objectives**

The genetic mechanisms of the central nervous system (CNS) patterning occuring during early ontogenesis are still poorly understood. (i) Members of the fork head (fkh) family of genes share homology at the level of a novel DNA-binding motif coding sequence and some have been demonstrated to regulate axis formation. I propose to further study a putative new mouse member to elucidate its function in pattern formation by using gene targeting procedures. (ii) Pax-3 and Pax-6 are transcription factors expressed in the embryonic CNS under the regulation of signals controlling the neural tube polarity. Drosophila, rat, mouse and human mutant studies indicate that they are important morphoregulators. In order to study their function in CNS patterning and cell differentitation, I propose to analyse the effects of ectopic expression of the Pax-3 and Pax-6 genes in the CNS under the regulation of the En-2 and Wnt-l gene promoter/enhancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'DEVELOPING A SCALABLE MOBILE AR BROWSER' (INDEXAR).

assistant: **Concept**

There is a global effort to increase the adoption rate of the Augmented Reality (AR) technology (Wikitude,Vuforia and recently Apple and Google), but things are still going slow.Some of these barriers are related to app development: the complex technical solution needed to bedeveloped (6-12 months), the costs they imply (30K – 90K EUR). A well documented and implementedUX/UI design also contributes to those high costs and long terms of delivery. Then there are other costs andeffort that add up, like content creation, maintenance, updates, marketing, retention.At the present moment, this technology is accessible only to big companies that have de budgets and theskilled teams to create and deliver AR experiences to their communities.We have identified an opportunity to disrupt this model and make the technology accessible also to SMEs,at better costs (approx. 1000EUR/ experience) in a matter of minutes through a SaaS solution – indexAR.indexAR is made of a web platform that helps content owners/creators (companies, advertisers, freelancers)become Authors of AR experiences at better costs and deliver them to their communities (Audiences) in amater of minutes, through a free iOS and Android Mobile app.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Large deviation estimates for atm traffic policed with the generic cell rate algorithm'.

assistant: **Innovation**

Research objectives and content The project aims at developing a method for calculation of overflow probabilities for the queue used to multiplex a large number of ATM connections described with the standardised parameters peak cell rate, sustain cell rate and burst tolerance. To this purpose, Large Defiation Theory will be applied. The technical problems that arise because of the partly deterministic nature of the sources wili be solved. Sources compliant with the traffic contract can be modelled as stochasiic sources followed by a queue delaying the non-confornung cells. A large number of such sources are multiplexed using a queue served at fixed rate. Large Deviation Theory is used to calculate the probabiiity of large queue lengths. In the final stage of the project, more general sources will be considered. Training content (objective. benefit and expected impact) The objective is to build up further expertise in the application of Large Deviation Theory to problems of telecommunications. In this way, a powerful technique for estimating buffer lengths in ATM equipment will become available by the project. To this end, tools used in design can incorporate the obtained results. Links with industry / industrial relevance (22) The applied probability group at DIAS (where the project is to be carried out) is involved in the EU funded study Measure" together with the Cambridge University computer laboratory and the Swedish telecom company Telia. The telecommunications group in Antwerp co-operates with Alcatel-Bell. Results of the project will be discussed with these partners."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Single-Clone Multi-omics Sequencing for Cancer Diagnosis' under Horizon Europe.

assistant: **Concept**

Cancer led to one in six death worlds wildly. By nature, cancer is characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Despite of the high cellular heterogeneity, only a small number of somatic mutations shown to be directly associated with tumorigenesis, hence driving cancer growth. The first hurdle in the cancer diagnosis is to identify these rare populations that have the potential to develop drug resistance. A second hurdle is to be able to associate mutations in the genetic level to the RNA expression level, which will improve the chance of pinpointing a specific mutation with the relevant activity. Therefore, it is of crucial importance to develop a single-cell multi-omics sequencing tool to simultaneously study the heterogeneity of expression and DNA-based regulation of cancer-associated genes. Recently, several multi-omics tools have emerged that allow for the interrogation of both gene expression and open chromatin regions. However, there are some notable limitations constrain the capability and applicability of these tools: 1) The expensive and disposable apparatuses and reagents of these methods is extremely expensive, and thus limits their extensive application and potential as a diagnosis tool; 2) The transcriptome derived from all these technologies only captures the 3 ' RNA termini of polyadenylated transcripts. It excludes the capture of non-polyadenylated transcripts which plays a vital role in cancer development, and the interrogation of somatic mutation from full length RNA. (3) The low input of single-cell material leads to the sparse data.  To overcome these hurdles, our novel technology is based on three methods that we have developed leveraging the power of microfluidics: 1. single-clone sequencing, 2.