RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of the right hemisphere in language recovery following stroke' (2002-2006).

assistant: **Innovation**

The potential of the right hemisphere to contribute to language recovery following lesions acquired in adulthood is controversial. On the one hand, post-lesional right hemispheric activation is often seen in patients showing poor language recovery. This seems to imply that language recovery relies mainly on spared left hemispheric language areas. On the other hand, contralesional areas might be particularly critical for residual language function in patients being most severely affected.   This project investigates the role of right hemispheric areas for language recovery following stroke in patients displaying either sensory or motor aphasia. Right hemispheric activation related to either language perception (sensory aphasia) or production (motor aphasia) will be identified using functional magnetic resonance imaging. The functional significance of right hemispheric activation will then be tested using transcranial magnetic stimulation.   Fibre tractography based on diffusion weighted magnetic resonance imaging will be used to reveal the connectivity of right hemispheric areas showing post stroke language related activation to left hemispheric language areas. Patients will be followed up during the process of recovery with detailed documentation of the speech therapy received during rehabilitation. Patients showing right hemispheric language related activation will be compared to patients showing only left hemispheric activation and to an age-matched healthy control group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantitative T cell Immunology' under Seventh Framework.

assistant: **Concept**

The primary objective of this ITN is to train a new generation of European quantitative immunologists, who will be able to address challenges arising in Systems Immunology. This will be achieved with the proposed Network, Quantitative T cell Immunology (QuanTI), that will train 11 ESRs and 4 ERs, bringing together renowned experimental and theoretical scientists from private and academic institutions.Health and disease are regulated, to a large extent, by our immune system. A quantitative approach to  Immunology must not only integrate a wide range of biological data but also increase our understanding of immunological processes at all levels of organisation. This will be achieved by exploiting state-of-the-art knowledge and technology of the academic and industrial partners.  The scientific programme  of the proposed Network consists of 6 research work packages and focuses  on one of the current challenges in Systems Immunology: the  dynamics of T cells in the periphery. Specifically the Network aims  to provide a coherent multi-scale framework to: (i) the establishment and diversity of the T cell pool in the periphery, and (ii) the differentiation programme of T cell populations during adaptive immune responses.  Synthesising models and immunological data poses a challenge that cannot be successfully managed by immunologists, mathematicians, computer scientists or physicists on their own.  QuanTI  will provide an excellent multi-disciplinary and inter-sectorial research environment to train a new generation of quantitative immunologists.The propose ITN will strongly advance the development of new quantitative concepts to characterise, and therapeutically  modify, immune responses.  In a wider context, QuanTI provides a model for a new, hands-on inter-disciplinary and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Assembly and application of photosystem ii-based biosensors for large scale environmental screening of specific herbicides and heavy metals' under Fifth Framework.

assistant: **Concept**

This project aims at:1) The realisation of sensitive and stable biosensors based on isolated photo system II (PSII) for the detection of herbicides and heavy metal.2) By screening of a large number of photosynthetic organisms and genetic engineering, production of PSII bio mediators able to distinguish the various subclasses of herbicides and heavy metals.3) Realisation of new-sophisticated transudation systems based on printed electrodes chemiluminescences and fluorescence as well as alternative systems.4) Development of miniaturised (smart") biosensor prototypes and special software to monitor the information deriving from the mutated PSII bio mediators.5) Practical on site application of the biosensors in a mobile unit for environmental screening under real operational conditions, i.e. leak-water from land fills and ground/river waters.6) Contribution toward spins offs and commercialisation."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a vaccine against helicobacter pylori' under Fourth Framework.

assistant: **Concept**

* To produce a genetically detoxified H. pylori cytotoxin protein suitable for evaluation as a vaccine candidate.* To assess the genetic variability of Chinese isolates of H. pylori, and to evaluate the relationship of this variability to the incidence of severe disease.* To test in the mouse model, vaccine candidates which show promise in protecting against European strains of H. pylori for their capacity to induce protection against infection by virulent Chinese strains.Expected Outcome* Identification of biologically relevant regions of the VacA protein.* A genetically detoxified and antigenically intact cytotoxin molecule as a vaccine candidate.* Serological data on the association of infection with Type I, VacA and CagA expressing strains with gastroduodenal disease in China.* Genotypic and phenotypic data on the variation of H. pylori strains in clinical isolates form Chinese patients and their assocation with disease.* Pathogenicity in vivo and in vitro of clinical isolates from China related to their genotype and phenotype.* Evaluation of the cytotoxin toxoids in conferring protective immunity against infection by European and Chinese strains of H. pylori.* A bank of monclonal antibodies raised against purified native toxin wil be screened for their ability to neutralize purified toxin.* Sequences coding for potentially non-toxic VacA proteins willl be created in E. coli by site directed mutagensis. Mutated genes constructed in E. coli will be transferred into H. pylori.* Mutated toxin proteins will be tested for their ability to induce gastric lesions after oral administration to mice.* Sera from Chinese patients undergoing routine endoscopy will be analysed for their ability to recognize CagA, VacA and other H. pylori antigens to ascertain any correlation with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Measuring how past sociocultural and environmental pressures shaped animal biodiversity: the extinction of the endemic small mammals of the Tyrrhenian Islands' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Human-caused biodiversity loss, including the extinction of a broad range of species, has dramatically increased over the years, with enormous repercussions on ecosystems worldwide. However, present-day species extinctions are only the latest stage in a considerably longer-term sequence stretching far back into the Holocene, when several extirpation events occurred in the prehistorical and historical eras. A remarkable case is the extinction of the last endemic small mammals of Corsica and Sardinia: while the large vertebrate fauna extinction occurred soon after the first human arrival (ca. 12,000 years ago), the small endemic mammals vanished much later, between the late prehistoric and Roman periods (8th c. BC5th c. AD), precisely at the moment when colonial agents as Phoenicians, Greeks, and Romans expanded and intensified trade networks. Although the disappearance of these species has been linked to anthropogenic causes, it remains uncertain whether this event occurred in both islands simultaneously as the result of a single, rapid cause or as a result of several interrelated causes. This project attempts to redress this imbalance and establish a new empirical framework by integrating cutting-edge analyses (GMM, DMTA, and direct 14C dating) with the abundant but underutilized archaeozoological record of the Tyrrhenian islands. This project will focus on three of these islands most emblematic speciesthe pika Prolagus sardus and the rodents Microtus (Tyrrhenicola) henseli and Rhagamys orthodonas proxies to investigate the mechanisms and effects of past human-induced environmental changes and how this is interconnected with the colonial and cultural exchange evidenced in the historical and archaeological records. Integrating archaeozoological data with other source mat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'SAR for Agriculture and Forestry in Europe'.

assistant: **Concept**

The goal of the SAFE Project is to provide an objective cost-benefit analysis of the ability of spacebome Synthetic Aperture Radar (SAR) data to meet the requirements of European agriculture and forestry. The importance of agriculture to the European economy, coupled with the fiscal importance of the Common AgricuHural Policy (CAP), provide the driving force for focusing on agriculture and forestry requirements. The need for a project of this nature arises from the perceived potential benefits of Earth Observation technology, and in particular SAR data, set against the current absence of any quantifiable justification for its use. The project methodology is based upon a breakdown of the work into three separate and independent phases: - Identification and prioritisation of user requirements - Development of the technological requirements and specification of a SAR mission - Analysis of the costs and benefits of the proposed SAR mission relative to current information gathering methods, and production of recommendations and an exploitation plan. Objectivity is assured through the use of separate organizations to undertake these activities. Each partner has been carefully selected to provide the necessary skills and experience in the relevant area as indicated in the table below: The results of the project are expected to be of particular interest to the EC, especially in relation to the requirements of the Common Agricultural Policy, to environmental policy and to future EC research policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MRTF/SRF signalling in regulation of cell senescence and melanoma progression' to be submitted under Horizon 2020.

assistant: **Abstract**

Myocardin-related transcription factors (MRTFs) are G-actin binding proteins which act as transcriptional co-activators Myocardin-related transcription factors (MRTFs) are G-actin binding proteins which act as transcriptional co-activators in association with the transcription factor SRF. MRTF-SRF target genes encode numerous proteins involved in actin dynamics, cell adhesion, migration and contractility. The subcellular localization of the MRTFs is controlled by actin binding which inhibits their nuclear import and promotes their nuclear export. Extracellular signals which activate Rho-family GTPases induce actin polymerization and G-actin depletion, which induces MRTF shuttling to the nucleus and transcriptional activation of MRTF-SRF target genes. The MRTF-SRF pathway activation via Rho plays an important role in cancer cell invasion and metastasis. In addition, in MRTF-SRF signalling inhibits cell senescence in hepatocarcinoma cells which present high Rho activity, but this has not been investigated in other cell types or cancer models. Cell senescence is a process of cell-cycle arrest which typically occurs in ageing, cancer, development or tissue repair, and can facilitate recruitment of immune cells. In the tumour microenvironment, senescent cells can direct events such as therapeutic resistance or metastasis that support malignant progression. In this project we will determine the molecular mechanisms by which MRTF-SRF signalling inhibits cell senescence in MEFs. We also aim to investigate the possibility for it to modulate melanoma progression in the BRafV600E mouse model, where senescence is an initial step prior tumour transformation. Increasing evidence suggests that anti- and pro-senescent therapies can be beneficial also in other pathologies, such as fibro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel multimodal endoscopic probes for simultaneous PET/ultrasound imaging for image-guided interventions' (ENDOTOFPET-US), addressing dissemination and exploitation.

assistant: **Impact**

In the frame of this project it is proposed to define and build a bi-modal PET-US (Positron Emission Tomography and Ultrasound) endoscopic probe combining in a miniaturized system a fully digital, 200ps time resolution Time of Flight PET detector head (TOF-PET) coupled to a commercial ultrasound (US) assisted biopsy endoscope and to launch the first steps of clinical validation.The project addresses and combines several objectives of the topics Health 2010.1.2-1, such as novel multimodality imaging tools, including a single photon (quantum) counting PET detector head for the purpose of identifying and quantifying morphologic and functional markers and of developing new biomarkers of tumoral processes at the preclinical and clinical levels. Moreover the endoscopic approach, combined with an unprecedented PET timing resolution will allow more sensitive, more precise, lower radiation dose and less invasive imaging and intervention on small internal structures and lesions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Deep genetics to study and uncover ‘hidden’ biology'.

assistant: **Objectives**

Human genes are organized in complex networks, to produce thousands of proteins to perform a myriad of functions. Whereas we have detailed maps for most biochemical pathways, the wiring of genetic networks in human cells is poorly understood.Development of powerful human genetic tools (CRISPR, RNAi, haploid cells), to which I made crucial contributions, have proven invaluable to study genetic networks. However, they face two major limitations. First, they provide information at the gene level, whereas it will be much more informative to understand genetic regulation at the level of protein domains or individual amino acids. Second, important biology can be masked – for example, by the cell state or interfering activity of other genes.With DeepGenetics we will bring our understanding of the genetic regulation of cellular phenotypes to the next level and mine ‘hidden biology’ that even impacts on well-studied cellular traits. We will (i) counterbalance the use of loss-of-function and gain-of-function genetics to obtain a solid gene-level inventory on the regulation of cellular phenotypes; (ii) identify genes that ‘mask’ unknown biology and use modifier screens to expose and define these processes – as we have recently exemplified in my group leading to the discovery of important new cellular pathways, and (iii) connect phenotypes to the functional protein domains and ultimately to the amino acid level. Thus, DeepGenetics will provide precise views on the regulation of key cellular phenotypes at the amino acid level and will cross the boundaries of our knowledge by exposing ‘hidden biology’.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'INNOvation beneFITs Europe' under Seventh Framework.

assistant: **Concept**

Having registered in 2006 the highest number of patents world-wide, Europe is deficient in benefiting from investments in knowledge. There is little demand for technology and customer oriented products and services. The goal of INNOFIT is to further the regions’ capability of “demand creation”, which allows SME, larger firms and research institutions to benefit from sales of products and services based on its knowledge. The proposal follows the strategy of “backing European winners” in their effort to catch up with global best regions. The consortium is composed of European SatNav regions, currently undertaking Galileo project.  The proposal is produced by the best Research and Development Clusters of the European Galileo/SatNav industry: Holland Rijnland and regions of Munich, Rome and Prague and its innovation and entrepreneurship centres. Aim of INNOFIT shall be focused on excellence in capability of demand creation for the Galileo downstream market from which a new 9 Billion € industry with over 140.000 jobs is expected to emerge. To achieve this INNOFIT will identify global best practices (WP 2) and state-of-play in the European regions of knowledge with show cases of demand creation capabilities that are adapted to European regions (WP 3). Integration activities in a joint action plan take place in WP4. Sustainability of project results is driven by the need for demand creation for new services from Galileo that will be operational by the end of INNOFIT. The innovation of INNOFIT is to assume that demand is not a given but can and need be created by forward looking activities of managers and policy makers. The focus here is on entrepreneurial initiatives supported with open innovation environments and living labs so that future customers and developers interact in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Forum alpinum 2002 - the nature of the alps'.

assistant: **Objectives**

Nature, its state or its absence, its perception, its use - and abuse - are the central topics of the FORUM ALPINUM 2002. The symposium will discuss the actual state of nature in the Alps from different perspectives, it will establish areas of future research and missing links where concerted actions and political interventions are needed. Since the EU is - together with the eight Alpine countries - signatory of the Alpine Convention, it is essential to elaborate a common understanding about the focal points of action both for science and national and EU policies.The fifth FORUMALPINUM, after Disentis (CH, 1994), Chamonix (F, 1996), Garmisch-Partenkirchen (D, 1998) and Bergamo und Castione della Presolana (I, 2000) was held in Alpbach (A) from 23 to 27 September 2002 under the general issue of The Nature of the Alps. It encompassed not only a scientific description of the actual state of the natural environment but also of our perception and the use of nature, and of natural protection. The participants have outlined perspectives for Alpine research, based on scientific expertise but also in a discussion with end users and stakeholders.So Alpbach became a meeting place for natural, cultural and social scientists with artists, theologians, managers, politicians and everybody who feels committed to the future of the Alps. We also listened to the local people, to school classes, to project leaders, and we offered them a forum for the exchange of ideas, results and concepts. It was, therefore, natural to include some practical aspects, such as water and wine sampling, and excursions, but also a concert, a performance and an art exhibition, all related with the central theme of the FORUMALPINUM 2002. The concept of the meeting does reflect the transdisciplinary character of