RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bio-derived HIgh Value polymers through novel Enzyme function', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Recent advances in systems-level study of cells and organisms have revealed the enormous potential to live more sustainably through better use of biological processes. Plants sustainably synthesize the most abundant and diverse materials on Earth. By applying recent advances in life science technology, we can better harness renewable plant resources and bioconversion processes, to develop environmentally and politically sustainable human enterprise and lifestyles. At the same time, the global market for high-value biochemicals and bioplastics from forest and agricultural sources is rapidly increasing, which presents new opportunities for forest and agricultural sectors.The overall aim of BHIVE is to illuminate uncharted regions of genome and metagenome sequences to discover entirely new protein families that can be used to sustainably synthesize novel, high-value biomaterials from renewable plant resources.  The approach will include three parallel research thrusts: 1) strategic analysis of transcriptome and metagenome sequences to identify proteins with entirely unknown function relevant to biomass (lignocellulose) transformation, 2) mapping of uncharted regions within phylogenetic trees of poorly characterized enzyme families with recognized potential to modify the chemistry and biophysical properties of plant polysaccharides, and 3) the design and development of novel enzyme screens to directly address the increasing limitations of existing assays to uncover entirely new protein functions. BHIVE will be unique in its undivided focus on characterizing lignocellulose-active proteins encoded by the 30-40% of un-annotated sequence, or genomic “dark matter”, typical of nearly all genome sequences. In this way, BHIVE tackles a key constraint to fully realizing the societal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Circuit-based deconstruction of Attention deficit and Hyperactive disorder with optogenetic Light control' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Attention-deficit/hyperactivity disorder (ADHD) like many other mental illnesses probably results from a combination of genetic and developmental factors pointing at abnormalities in brain monoamines (MA). Imaging studies in ADHD patients also indicate deficits in activity of various brain regions including the prefrontal cortex (PFC) and basal ganglia (BG). The mechanisms by which PFC and BG dysfunctions are triggered, and can be corrected with MA-based treatment are unknown. Although there is a consistent frontal hypoactivity detected in ADHD, some variations are seen amongst executive processes including attention or impulse control, in which MA have specific functions. Besides, the limited spatial resolution of brain imaging does not allow to detect certain subregions or discriminate neuronal subpopulations. In order to identify brain network impairments in ADHD, we need models to further dissect frontal dysfunctions looking at MA signaling, cell excitability and behavioral correlates of activity in identified neurons.The goal of this project is to untangle brain circuits involved in a novel mouse model of ADHD, which fulfills the major criteria reflecting human condition, showing specific BG dysfunctions and differential MA involvement. Innovative approaches have been chosen to accomplish this challenge that include transgenesis, opto- and pharmaco-genetics, and in vivo measurement of neuronal activity in translational behavioral tasks assessing attention and impulsivity. Importantly, while the most common medication using psychotimulants has proven the best efficiency, it has also been shown to affect children growth and their adult mental health highlighting the urge for alternatives. We believe that our model and multidisciplinary methodology provide new insight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Active large-scale learning for visual recognition' (ALLEGRO) under Seventh Framework.

assistant: **Objectives**

A massive and ever growing amount of digital image and video contentis available today, on sites such asFlickr and YouTube, in audiovisual archives such as those of BBC andINA, and in personal collections. In most cases, it comes withadditional information, such as text, audio or other metadata, that forms arather sparse and noisy, yet rich and diverse source of annotation,ideally suited to emerging weakly supervised and active machinelearning technology. The ALLEGRO project will take visual recognitionto the next level by using this largely untapped source of data toautomatically learn visual models.  The main research objective ofour project is the development of new algorithms and computer softwarecapable of autonomously exploring evolving data collections, selectingthe relevant information, and determining the visual models mostappropriate for different object, scene, and activity categories. Anemphasis will be put on learning visual models from video, aparticularly rich source of information, and on the representation ofhuman activities, one of today's most challenging problems in computervision. Although this project addresses fundamental researchissues, it is expected to result in significant advances inhigh-impact applications that range from visual mining of the Web andautomated annotation and organization of family photo and video albumsto large-scale information retrieval in television archives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Air-Brayton cycle concentrated solar power future plants via redox oxides-based structured thermochemical heat exchangers/thermal boosters' (ABraytCSPfuture).

assistant: **Concept**

ABraytCSPfuture sets forth an innovative, carbon-neutral way for implementing into future air-operated CSP plants the inherently much more efficient air-Brayton gas turbine power generation cycles in order to achieve higher solar-to-electricity efficiencies, vital for competitiveness of CSP and non-reachable by either PVs or molten salts and thermal oils, significantly increasing in parallel the plants’ storage capability. Both these functionalities will be made possible by developing and demonstrating the integrated operation of a first-of-its-kind, compact, dual-bed thermochemical reactor/heat exchanger design, comprised of non-moving, flow-through porous ceramic structures (honeycombs or foams) based on earth-abundant, inexpensive, non-toxic oxide materials, capable of performing simultaneously the following:•transferring heat from a non-pressurized air stream to a pressurized one, while operating simultaneously as a “thermal booster”, raising the temperature of the pressurized stream to levels required for gas turbine air-Brayton cycles.•Increasing significantly the volumetric solar energy storage density of such air-operated CSP plants by rendering their current sensible-only regenerative storage systems to hybrid sensible-thermochemical storage ones, within the same storage volume,Both these functionalities will be materialized by exploiting reversible reduction/oxidation reactions of such oxides in direct contact with air, accompanied by significant endothermic/exothermic heat effects. The first one in particular, will be achieved by performing the reduction of these oxides with solar-heated air streams under atmospheric pressure but their exothermic oxidation with pressurized air streams. The proposed technology is set forth by an interdisciplinary partnership s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Functional and Molecular Characterisation of Breast Cancer Stem Cells' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. These transformed stem cells harbour long-term proliferative potential and the ability to regenerate tumours consisting of phenotypically heterogeneous cell types. The identities of cancer stem cells (CSCs) that give rise to breast tumours are incompletely understood. The mammary gland is composed of a complex cellular hierarchy, which undergoes most of its development postnatally. To achieve this great plasticity, both stem and progenitor cells play a pivotal role in the extensive tissue remodelling occurring during puberty and pregnancy. Deregulation of stem and progenitor cells is a key event in mammary carcinogenesis. Recently, the host laboratory identified a rare unipotent progenitor cell population in the adult murine mammary gland characterized by the surface protein leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6).  Oncogenic mutations in Lgr6-positive cells led to the formation of luminal mammary gland tumours, and contributed to tumour aggressiveness and maintenance. Conversely, depletion of Lgr6-positive progenitors in mouse luminal breast cancer dramatically impaired tumour growth and morphology. However, the underlying molecular mechanisms driving these observations are unknown. The aim of this project is the characterisation of Lgr6-positive breast cancer stem cells, using functional and molecular approaches. We will characterise the molecular differences between
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Clean Aviation Support for Impact Monitoring'.

assistant: **Objectives**

The CLAIM proposal main high-level objectives are:1. To obtain an answer on how to best translate the Clean Aviation Programme objective to reduce net greenhouse gas emissions by -30% versus state of the art into tangible metrics in terms of measurable engine tailpipe emissions, bya. Collecting, analysing and establishing the current level of scientific understanding within the worldwide community of climatology and atmospheric sciences, and of aviation climate impact and its greenhouse gas emissions contributions;b. Identifying knowledge gaps, barriers, and needs for research in view of orienting more appropriately the technology research streams for future green and zero-emission aircraft.2. To compile an inventory of relevant aeronautical advanced research activities and technology areas, not only from the aviation community but potentially also from other sectors if relevant bya. Reviewing and analysing aeronautical literature on disruptive aircraft concepts or greener aircraft as well as on climate-neutral aviation in general, including their (preliminary) environmental performance/results;b. Proposing a way forward and an approach that highlights the assumptions and metrics used to reconcile the numbers and the prospects of performance improvements for the main technologies;c. Categorising these concepts in terms of aerodynamics, structural, systems and propulsion technologies and their associated benefits at aircraft level, as well as performing a technology mapping;d. Performing a preliminary performance assessment using proposed assumptions and criteria for an SMR and an HER.Consequently, through achieving its objectives, the CLAIM proposal assists Clean Aviation, EC and EASA by providing more clarity and contributing to all of the expected outcomes


**Keyword
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Extended Subtractive Synthesis of Audio Signals' under Seventh Framework.

assistant: **Concept**

The purpose of this proposal is to generalize the subtractive sound synthesis method for digital audio applications.Whereas the basic idea of Additive Synthesis consists in adding the sinusoidal components of a Fourier series, the analog Subtractive Synthesis aims to imitate a given periodic sound by filtering a fixed excitation signal (usually square, triangle or sawtooth signals). With this source-filter principle, the spectral envelope is reproduced by designing the filter.For some decades, the Additive Synthesis has been significantly improved for computer applications, but the Subtractive Synthesis not. Actually, on one hand, the recent digital subtractive synthesizers focus on modelling old analog synthesizers since the 1960s (from which the Moog is the most popular), and on the other hand, the source-filter principle has been improved for the particular case of the speech coding and synthesis only.Here, we plan to apply recent advances of the audio processing field to derive a new Extended Subtractive Synthesis method. For example, we will study the use of time-varying filters and pitch trajectories to reproduce transients, modulations and roughness. With learning from recorded sounds, we will estimate the parameter trajectories. Moreover, we will use knowledge about psychoacoustics to imitate the original sound from a perceptual viewpoint. This new synthesis technique will have applications in sound synthesis of harmonic musical sounds, and we plan also to synthesize animal sounds. The new method will also be useful for computer game audio. Moreover, most of usages of current Additive Synthesis could be applied, such as time or frequency stretching or noise removal. The main benefits of the Subtractive Synthesis are the reduced number of parameters and the easie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Chemical Biology at Cambridge - ChemBioCam'.

assistant: **Objectives**

Biological chemistry is a vital discipline at the interface between chemistry and biology, which underpins the development of the European pharmaceutical, biotechnology, and agrochemical industries. This interdisciplinary subject is at a crucial and exciting stage, and the demand for trained personnel has never been higher. The aim of this project is to establish a centre of excellence in research training, which draws on the established strengths in Chemistry and Biology at Cambridge. The goal of the training programme is to bring together leading groups with diverse and complementary skills in structural biology (NMR and X-ray), molecular recognition, synthetic chemistry, manipulation of biosynthetic mechanisms, enzymology, mechanistic organic chemistry or protein science - all aimed at understanding and manipulating the molecular machines that nature has evolved. The understanding of the molecular basis of life will provide the ultimate foundation on which to develop the advances needed to eliminate disease. The training programme benefits from existing interdisciplinary structures within the University and seeks to enhance and develop these innovatively. It puts significant emphasis on developing entrepreneurial awareness, by including formal teaching on commercial issues and including interaction with SMEs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Source to Seas - Zero Pollution 2030 (SOS-ZEROPOL2030)'.

assistant: **Concept**

The overall aim of  'Source to Seas - Zero Pollution 2030 (SOS-ZEROPOL2030)' is to develop a holistic zero pollution framework which can guide the process towards achieving zero pollution in European seas by 2030. Marine contamination (including pollution) occurs as a direct result of human activities on both; land and in the marine environment; and requires urgent attention as healthy and clean seas provide numerous ecosystem services (e.g. food, oxygen production, climate regulation), which are critical for our survival and wellbeing. Given the complex and interconnected nature of marine pollution, the integration of sustainability-focused agendas and circular economy principles and practices is essential for the development of effective actions that can address its impacts. The implementation of processes and measures to reduce marine pollution will have consequences for numerous economic sectors (e.g. agriculture, fisheries, food and beverage industry, waste management, packaging industry, tourism, offshore energy) at multiple scales (local, national, regional and international), framing marine pollution as a considerable global socio-economic challenge that requires active collaboration from multiple stakeholders, across a range of geographic areas. In this context SOS-ZEROPOL2030 aims to co-design, co-produce, and co-deliver a stakeholder lead European Seas zero-pollution framework that provides practical guidance from source to sea addressing shortcomings in marine pollution management and governance. This holistic approach is based on best practice, puts emphasis on human behaviour, socioeconomics and governance; and is underpinned in knowledge about and understanding of current barriers to effective and efficient prevention, reduction, mitigation and monitoring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Automated and differentiated calculation of sustainability for cod and haddock products' (WHITEFISH).

assistant: **Concept**

The European whitefish catch and processing industry is dominated by SMEs, and it is currently facing several challenges. Worldwide many stocks have collapsed, and environmental organizations warn against consuming captured whitefish. Strict regulations with respect to documentation and traceability have been imposed on the European captured fish industry in the last few years, and fulfilling these generates significant additional cost. While some cod/haddock stocks, particularly in the north-east Atlantic, are still healthy and sustainable there is a problem for these species when they get to the market. This is due to competition from cheap farmed whitefish species, in particular pangasius and tilapia imported from Asia/Africa. The goal of the WHITEFISH project is to strengthen the competitiveness of the European cod/haddock industry by documenting the desirable characteristics of whitefish caught in the north-east Atlantic, in particular relating to sustainability (stock, environmental, economic and social). The specific objective of the project is to develop and validate an objective and transparent method to document the sustainability impact of captured fish products. The method will be based on Life Cycle Analysis (LCA), and it will calculate sustainability impact on production batch level as opposed to generic product type level which is current practice. This will enable differentiated calculation of environmental impact, so that products that look identical may be shown to have different properties, for instance related to food miles or CO2 emissions. The method will utilize existing recordings in the company traceability systems, so that food businesses may perform their own calculations of sustainability without needing to involve external experts. The metho