RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Harnessing advanced computational and synthetic biology to understand phage lysin complexity'.

assistant: **Innovation**

(Endo)lysins are phage-encoded enzymes that degrade the peptidoglycan layer of bacterial cell walls, facilitating the release of viral progeny. Both wild-type and engineered lysins have shown promise as alternatives or complements to antibiotics, of importance in light of rising antimicrobial resistance. However, current lysin research and development (R&D) efforts remain largely empirical, needing resource-intensive screening processes that often yield limited generalizable insights. This challenge is further compounded by the recent failure of the first clinical trial intended as proof-of-concept for lysins as antimicrobials, alongside new findings that demonstrate an unexplored complexity of lysins.This makes the case for an investment in fundamental research to address unresolved questions about lysin structure and function. Specifically, this project will explore two major issues related to lysins from the two major bacterial macrostructural paradigms, namely: (i) the specificity determinants of enzymatically active domains (EADs) in Gram-positive lysins and (ii) the role of cell wall binding domains (CBDs) and antimicrobial peptide-like elements (AMLEs) in Gram-negative lysins.To achieve this, I will deploy, for the first time in the field, advanced computational methods to generate fully synthetic lysins that will serve as scaffolds for testing specificity determinants in EADs. In addition, I will develop an ""in virio"" testing platform (IVTP) in collaboration with a research network that this project will help establish. The IVTP will be central to the project, allowing for the evaluation of functional diversity within the context of the phage-host interaction, thus overcoming the applied bias in current lysin research.Ultimately, this project will deepen our u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Interactions between vision and audition in human motion perception.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Human sensory perception is multisensory in nature. Strong interactions between Vision and audition have been observed in neuropsychological and behavioural studies. The objective of this proposal is to identify how audition and vision interact in sensory perception. To this end, the experiments use psychophysical techniques to explore three themes:(i) whether complementary auditory cues can enhance visual perception,(ii) whether complementary visual cues can enhance auditory perception,(iii) how audition and vision interact at potpie (bright) vs. isotopic (dim) light levels. A fourth general theme will be functional brain imaging of audiovisual interactions. These experiments ask new questions those cross-traditional boundaries between vision and audition. Results will advance our understanding of visual and auditory processing as interacting systems, with the goal of moving towards an integrated theory of sensory perception. As auditory and visual perception have existed as separate specialisations for an over century, the time is ripe for this evolution. Moreover, as cross-modal interactions exist in other combinations, audiovisual interactions will lay important foundations for a general understanding of integrated sensory perception. Thus, the project will ultimately lead to a reconceptualisation of human perception as a polysensory process and a consequent revision of unmoral perceptual models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dynamical imprints of the evolutionary history of the Milky Way' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Galactic Astronomy is entering a new era, driven by state-of-the-art instrumentation and large surveys, and by the dramatic leaps in our understanding of galaxy formation provided by the cosmological LCDM framework. These surveys have shown that the Galaxy is up for discoveries every single month, and have revealed the first footprints of past mergers. This Era will reach its summit when the Gaia mission, scheduled for launch in 2011, provides the much-awaited survey of Galactic phase-space for a billion stars. This motivates us to propose a program that will provide a comprehensive view of the dynamical imprints leftover from the Galaxy s evolutionary history. This program will address the following key questions: How much memory does a galaxy like the Milky Way retain of its past? What is the relative importance of internally driven (secular processes) and externally acquired (mergers) phase-space substructure? What was the merging history of the Galaxy? Is the Galaxy consistent with LCDM? This ambitious program will advance the field of Galactic archaeology beyond the state-of-the-art thanks to two developments: the Aquarius Project simulations and the RAVE spectroscopic survey. The Aquarius are the largest ever cosmological simulations of a Milky Way dark matter halo. When complemented with a recently built phenomenological galaxy formation model, these superb simulations will serve for comparisons to the latest observational datasets, and in particular to the RAVE survey that is providing a fantastic dynamical map of the Solar vicinity. This will enable us to be in prime position to exploit the first Gaia data release in 2013, and before the end of this Research Program, to harvest its key scientific goal, namely to unravel the assembly history of the Milky Way.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'In Situ Nanoscale Mapping of CO2 Photoreduction over Low-Dimensional Semiconductor Photocatalysts' (ISaaC).

assistant: **Innovation**

The conversion of the greenhouse gas carbon dioxide (CO2) into high-value chemicals and fuels by using solar-powered devices represents a promising and sustainable strategy to achieve the target of climate neutrality by 2050. The development of an efficient technology for photocatalytic CO2 reduction (CO2RR) requires an in-depth knowledge of the reaction mechanism, which is, to date, still elusive. In particular, photocatalysts often consist of nanomaterials which are difficult to study at the single-entity level. In this context, ISaaC represents an effective solution to unlock the working principles of photocatalytic devices for CO2RR. To guide the design of future advanced photocatalysts with improved performances, this project proposes an in situ photochemical nanoscopy of  CO2RR over low-dimensional semiconductors and plasmonic metal-semiconductor heterojunctions judiciously designed through top-down nanofabrication. Based on a unique nanoprobe, combining at-source photonic and electrochemical functionalities, ISaaC aims at realizing via light-assisted scanning electrochemical microscopy (Photo-SECM) in situ photochemical analysis of individual nanocatalyst entities, as well as mapping with unprecedented local illumination conditions (sub-100 nm). The collected nanoscale information will be correlated with data provided by operando Raman spectroscopy to confirm the role of the device towards CO2RR. ISaaC identifies three objectives to enable mechanistic insights into individual nanoscale photocatalysts for CO2RR: 1) development of a Photo-SECM plasmonic probe as an individual photocatalyst. Investigation of its plasmon-assisted photochemical response; 2) development of optimized Photo-SECM nanotip with nanoscale light irradiation. Demonstration of improved spatial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'All-Optical Dissection of Hippocampal Circuits Using Voltage Imaging' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The hippocampus is critical for the storage of episodic memories and has been extensively studied on its role in spatial memory. The hippocampus is also a central model for in vitro studies on the molecular, cellular and microcircuit basis for learning and memory. I propose to use a new technology that I developed to record and manipulate the membrane potential of multiple neurons, simultaneously, in behaving animals to reveal the mechanisms by which hippocampal circuits process spatial information. This research will bridge the gap between the in vitro mechanistic studies and the in vivo efforts to describe the spatial representations.I first propose to employ the voltage imaging technology for detailed mechanistic studies of the function and plasticity of hippocampal microcircuits during place cell formation (Objective 1). To this end, we will combine voltage imaging with Optogenetics in head-fixed mice performing virtual navigation in familiar and novel environments. To expand to a ‘systems’ view on hippocampal plasticity, we will next establish a method for optical selection of single neurons based on their functional profile (Objective 2). We will use this technology to trace the long-range projections and the pre- and postsynaptic landscape of photo-selected CA1 neurons. In the last objective, we will combine both technologies to dissect the contribution of different entorhinal cell types (i.e. grid cells, border cells, and speed cells) to place cell formation in CA1 (objective 3). To this end, we will image the entorhinal cortex and photo-select cells based on their functional profiles. We will then image CA1 while manipulating the activity of the selected entorhinal cells. Our work will provide new discoveries on the mechanistic basis for spatial memory and will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Consent in Songs in European Narrative Traditions', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

CONSENT examines the theme of sexual consent in European narrative traditions as represented in late medieval songtexts (c.1300-1550). It investigates the new and empowering narratives that were performed to engage in conversations about consent. Since songs were part of oral culture, circulating among various social classes and voicing contemporary views on societal affairs, they offer an indispensable gateway to medieval understandings of this timeless topic. The project will bring forth methodological innovation by making sexual consent (not: coercion or forced sex) its main lens for analysis. By introducing a consent-based approach to historical literature, CONSENT will showcase consent as a rich medieval literary theme and investigate how songtexts helped medieval people to explore positive scenarios for behaviour in sexual relationships. These aims are crucial to balance previous scholarship, that has focused on medieval narratives about rape. CONSENT, however, posits that current societal debates prompt a different, more positive perspective, unravelling a consent-oriented part of late medieval culture. First, CONSENT will trace WHERE consent-themed songtexts circulated. While rape-themed song seems to have flourished throughout Southern Europe, France and England, CONSENT will shift focus to Germanic traditions, hypothesizing that these lend a stronger voice to consent. Second, CONSENT will analyse HOW these songtexts represented ideas about sexual consent and mutuality, by applying a novel close-reading method that studies intersections of gender, social status and narrative space. The project hypothesizes that medieval songtexts adopted recognizable narrative patterns to express sexual consent and to contradict and destabilize rape narratives. Third, CONSENT w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'A highly efficient CRISPR/Cas9 gene editing method for difficult to transform arthropods'.

assistant: **Concept**

During the ERC consolidator grant POLYADAPT, an efficient gene editing system was discovered which allows to genetically transform the spider mite, Tetranychus urticae, a main crop pest. This species belongs to the chelicerates, the second largest group of arthropods including mites, ticks and spiders, that are notoriously difficult to transform. Our invention not only accomplished for the first time gene knock-out in mites, but also allows precise gene editing via knock-in with high efficiency. The method results in a 20-fold increase of transformation efficiency. In the PoC CRISPART, we will demonstrate the efficacy of the invention on a wide range of difficult to transform arthropods and aim to better understand the mode of action of the observed synergy. We will further investigate the optimal validation trajectory of the invention, considering a gene editing service and investigate commercial and financial feasibility of the optimal path.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Firms, International Trade, and Aggregate Fluctuations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This project will provide a detailed account of the role of individual firms in generating aggregate fluctuations using data covering the universe of French firms for the period 1990-2007, and highlight the importance of international trade in the analysis of of firm shocks and aggregate volatility. The project  will complete six objectives. First, it will lead to the construction of a new firm-level dataset that merges firm domestic and export sales, along with other firm-level characteristics. Second, it will provide new methodology to identify firm-level idiosyncratic shocks by exploiting the export-orientation of firms, and estimate these shocks. Third, it will quantify the contribution of the idiosyncratic shocks to the volatility of aggregate sales growth. Fourth, it will measure the importance of firm-level interconnectedness in propagating idiosyncratic shocks into aggregate volatility. Fifth, it will estimate how a firm’s export and import orientations affect its exposure to shocks, as well as its ability to diversify risk. Sixth, it will quantify the implications of firms’ export and import orientations on aggregate volatility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Equality for the Market. The National Usages of EU Equality Policies' (EQUALUSES) under Seventh Framework.

assistant: **Objectives**

This research project consists in analysing the influence and effects of European policies on national transformations in the fields of reconciliation between paid work and private life and anti-discrimination. More precisely, this research project ambitions to contribute to the understanding of the concrete mechanisms thanks to which the EU contribute to the transformation of national models of reconciliation and anti-discrimination, not by imposing a common model or precise reforms but by providing actors with resources useful for their political work and strategies. In this sense, the development of an approach based on the “national usages of Europe” will contribute to the academic debate on the Europeanization of public policies. The research question that will be examined in the EQUALUSES project is whether the utilitarian shift in policies combating discrimination and reconciling paid work and private life at the EU level has also occurred at the national level and what has been the possible influence of the EU on national developments. In order to do so, this project will compare policy reforms in Belgium, Sweden and the United Kingdom since the beginning of the 1990s, while attempting to identify the EU’s role in these evolutions. From a theoretical standpoint, this project aims at participating to the “sociological turn” in the study of the European Union and to complement the dominantly institution-focused approach of this literature, which has led to an underestimation of the discretion and role of political actors in the adaptation processes, especially by taking into account new social practices opened up by the process of Europeanization. From a methodological standpoint, the use of CAQDAS techniques and Qualitative Comparative Analyses will provide some
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Excitonic transport in cold Rydberg gases', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The study of transport phenomenon based on quantum processes, where energy and information are transported but neither charge nor mass, is a vivid and interdisciplinary field of research raising both fundamental and technological issues.During this fellowship, we propose to use laser-cooled ensembles of atoms in highly excited states (cold Rydberg gases) to study such transport phenomenon.The overall purpose of the action is to demonstrate that cold Rydberg gases can be used as an innovative, efficient research platform which would allow to further address fundamental challenges related to the transport of energy and information.\\The principal objective of this project is to form a chain of Rydberg atoms, to locally place an additional electronic excitation (exciton) in the chain and to observe the subsequent transport dynamics.A second objective is to implement adiabatic excitation of collective Rydberg excitations in order to prepare deterministically a Rydberg chain.This project will be implemented in a world leading group in cold Rydberg gases where the applicant will use two complementary experimental setups to address the different aspect of the objectives in the best conditions. He will be supervised by their respective principal investigators which will provide a strong management structure to the project.Building around the applicant's experience in the field of cold Rydberg gases, this fellowship will provide him with new, cutting-edge experimental skills which would establish him as a leading researcher in this field. The innovative, high quality research which will be carried out during this fellowship will serve as a basis for the application to a permanent position.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantifying the link between weathering and past CO2 levels' in the context of a Horizon 2020 call.

assistant: **Objectives**

The carbon cycle is a vital aspect of our planet’s well-being. However, there are fundamental aspects of it that we do not understand, without which we cannot accurately quantify CO2 budgets. How, and at what rate, does the carbon cycle respond to, and recover from, events of rapid and extreme global warming or cooling? What process has maintained the climate within a habitable range for billions of years? Silicate weathering is Earth’s main long-term CO2 removal process, and therefore a dominant climate control mechanism. Critically, we do not understand the controls on silicate weathering, or its full effects on atmospheric pCO2 and climate. The goal of this project is to determine and quantify how weathering responded during past periods of rapid climate change, using an innovative combination of novel stable isotope techniques, laboratory experiments and advanced carbon cycle modelling. This will determine the behaviour of a key, relatively unknown, factor in the carbon cycle. This project comprises three, highly novel, interlinked strands: 1) Examination of the palaeo-weathering record through recent glacial timescales using cave speleothems as a climate archive, 2) Determination of palaeo-weathering records through older, Cenozoic, rapid shifts in climate, using marine carbonates and clays as an archive, and 3) Advanced models to enhance our understanding of this record. This project will radically improve our quantitative knowledge of the controls over the carbon cycle. This is critical because 1) it is possible that weathering is the process that has maintained Phanerozoic climate in the relatively narrow bands required for life; 2) it is impossible to decipher the causes and consequences of long-term climate variations through Earth’s history without accurate w