RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cell type-specific endometrial dysfunctions across the menstrual cycle and their potential for drug interventions in polycystic ovary syndrome' in the context of a Horizon Europe call.

assistant: **Objectives**

Polycystic ovary syndrome (PCOS) affects 11-13% of reproductive-age women and is one of the leading causes of anovulatory infertility. Women with PCOS have elevated androgen levels, polycystic ovarian morphology, and ovarian dysfunction. The PCOS endometrium is exposed to constant estrogen, which leads to progesterone resistance and impaired decidualization. As a result, PCOS women are twice as likely to have a non-receptive endometrium. This hinders embryo implantation and increases the risk of pregnancy complications, such as miscarriage. However, whether changes in the cellular complexity and heterogeneity of the endometrium during the menstrual cycle contribute to PCOS-specific endometrial dysfunction remains unclear.  The overarching aim of this MSCA-PF project is to uncover PCOS and cell type-specific endometrial dysfunction across the menstrual cycle at the single cell level and to test whether the identified markers can serve as targets for future drug development. Using a unique collection of human endometrial biopsies from women with and without PCOS and single nuclei RNA sequencing, I will (1) map the endometrium at the single-cell level at four different menstrual stages, define the composition of cell types and key molecular regulatory networks; (2) establish and characterize 3D mono- and co-culture models of patients endometrium and investigate their ability to mimic tissue of origin; and (3) determine factors that facilitate PCOS-specific epithelial-stroma communication and endometrial response to novel drug treatments. By accomplishing these goals and sharing the transcriptomic data as a PCOS endometrial cell atlas and protocols for patient-derived cell models, the proposed project will provide valuable resources for new discoveries. Ultimately, the proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Discovering Quorum sensing in industrially useful Fungi, a novel approach at molecular level for scaling-up in white biotech' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Fungi have proved to be a source of bioactive natural products and industrially important target products such as:(i). Enzymes,(ii). Bioplastics,(iii). Bio-dyes,(iv). VitaminsThe overall aim of this proposal is to use nanotechnology using natural molecules involved in fungal cell communications and mini-scale process parameters, to maintain and improve productivity for the white biotech industry of the commercially important bioproduct, and particularly laccases. The specific objectives of this proposal are: Using a Quorum Sensing approach at nano-scale for better understanding of biosynthesis of the industrially important target products; Quorum sensing and signal transduction in relation to fungal physiology and morphology in agitated systems; Comparative analyses of fungal cell communication in small and large scale submerged fermentations; The relevance and interrelation of traditional scale-up factors to quorum sensing in fungal cultures. The QUORUM project is based on a multidisciplinary approach, and builds a dynamic relation between 8 partners (1 SME and 7 Universities and Research Centres) from 7 countries.The QUORUM project will enhance competitiveness and sustainability of European industries by the development of leading edge advances i n environmentally respectful, energy efficiency, resource efficient processes and product technology. Two main technology innovation areas are concerned: enzymes and fine chemical productions. The QUORUM project will lead to a positive impact on economy through new/increased added value products, a beneficial impact on environmental issues, and new production models -based on knowledge- to replace trial error, will be proposed to the industrial biotechnology sector in the value chain.The QUORUM project will support the Action
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Engineering Graphene for developing Neural Interfaces to revolutionize how we treat neurological diseases' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Neurological disorders represent one of the greatest healthcare challenges for our society (1B affected people worldwide). 25-35% of these patients are refractory to pharmacological therapy and are left with no options. Neuroelectronic therapies, aimed at recording and stimulating brain activity to restore normal brain function, are emerging as a safe alternative for them. However, current neuroelectronic implants are made of big metal leads with multiple limitations, such as poor resolution, low specificity and high invasiveness.We, at INBRAIN Neuroelectronics, have the solution. We are developing a completed platform of intelligent neuroelectronic interface systems powered by Graphene dots. We are developing graphene-based neural implants that, powered by AI, will have the capability of reading single neural cells at a resolution never seen before, detecting therapy-specific biomarkers and triggering adaptive responses for increased outcomes in personalized neurological therapies.


**Keywords:** Brain computer interfaces,brain mapping,neurological disorders,Deep Brain Stimulation (DBS),cortical & subcortical neural circuits,Parkinson’s Disease (PD)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'NEW INTEGRATED SYSTEM FOR THE MANUFACTURING OF WOVEN TEXTILE SAMPLES' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

For today's textile and fabrics market it is absolutely essential to present updates and new designs both for fashion and industrial fabrics. At present, the European market for woven products is highly automated. The high cost of equipment and the technical complexity involved in the development and manufacturing of woven samples and new fabrics (in most of the cases 25 cm of fabric is sufficient) means that it is uneconomic to produce samples on large production lines.The current situation can be summarised as follows:- the present productive machines are completely automated. These machines are designed for production in series, and not for very short runs.- the fabrics made by the present machines are too wide for samples.- the cost of the present machinery does not permit stoppages.The objectives and benefits of this project were:- a considerably increased level of customer service through a 90% reduction of time required to develop new samples- human errors are reduced- manufacturing cost of samples reduced by 50%- additional cost saving since there is no more need to shut down the main manufacturing looms of the company which are usually used for production.Subsequently a new system has been developed, which based on CAD/CAM can produce the fabric samples with a maximum width of 50 cm. Project developments included:- a new computer system to create the design with a library of 100.000 patterns- a CAD/CAM link to the sample producing machine- a new, highly simplified loom, with a weaving width of 50 cm equipped with a Jacquard machine and individual thread commands.- a finishing line of machinery to work with 50 cm width fabrics with all the necessary processes including treatment, washing, dyeing, drying.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Multifunctional MEdical DIagnostic LASEr System'.

assistant: **Objectives**

MEDI-LASE proposes to perform a joint research programme capitalising on the knowledge and expertise of the partners through exchanges of researchers and transfers of knowledge between research centres at the University of Dundee, Laser Physics and the Institute of Medical Science and Technology and two SME companies with expertise in different aspects of photonics based diagnosis, a manufacturer and developer of state-of-the-art medical diagnostics equipment ASKION GMbH and a Russian developer of integrated diagnostic laser systems LAZMA. The aims are to overcome scientific and technical challenges to the realisation and adoption of a unique multifunctional non-invasive laser diagnostic system. Specifically, new and novel laser sources will be developed and validation of the spectroscopy and complex algorithms required to provide relevant and reliable diagnosis of specific biological conditions. The work will comprise experimental research in the optical analysis of blood and tissue to direct the exploitation of the developed system. The project will draw on technology and expertise from all three partners while training 4 early stage researchers and providing career development opportunities for 4 recruited experienced researchers. Many opportunities for further research collaborations exist between the partners and it is anticipated that MEDI-LASE will facilitate the development of relations to catalyse ongoing long-term collaborations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Using clouds as a natural laboratory to improve precipitation forecast skills' (CLOUDLAB).

assistant: **Innovation**

Clouds have been seeded since the 1940s. Aimed at inducing weather modification, the method uses chemicals to alter the microphysical processes within a cloud to enhance precipitation, suppress hail, or dissipate fog. While the concept of cloud seeding is not new, detailed knowledge about the underlying microphysical processes in clouds is still sparse. CLOUDLAB will tackle this gap by injecting different ice nucleating particle concentrations into supercooled stratus clouds to investigate related microphysical changes, including fundamental aspects of ice formation and growth. To achieve this, the project combines a multi-dimensional approach of targeted cloud seeding with a focus on wintertime stratus clouds in Switzerland, the least dynamic cloud type which best mimics laboratory conditions and allows repetition of field experiments under similar initial conditions. We will inject ice nucleating particles from a seeding drone and perform measurements with ground-based remote sensing, a tethered balloon system equipped with a holographic imager and a measurement drone. Combined with measured meteorological parameters, we aim to understand the impact of cloud inhomogeneities for precipitation initiation via the ice phase. The analysis of our cloud seeding events will be used to validate and improve cloud microphysics schemes in the Swiss weather forecast model in large eddy simulations mode. By coarsening the horizontal resolution to weather forecast mode, the simulations will be extended to include all cloud types where the same microphysical processes are at work to improve precipitation forecast skills in Switzerland. Hence, CLOUDLAB will further the understanding of ice microphysics and precipitation initiation which will also improve climate projections. In additi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Private Operation and Financing of Trans-European Networks' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

PROFIT will look at options to bridge the gap between the financial profitability of TEN projects and their socio-economic rentability by facilitating and promoting public-private-partnerships (PPP) to finance and operate TEN projects. The project will- develop a structured methodology for assessing the PPP potential of a TEN project, based on financial attractiveness and socio-economic costs and benefits.- define and assess the network effects in TENs- establish an Expert Group consisting of private companies and government bodies in PPPs, which will function as a consultative body for the project- provide a user friendly and easy-to-use tool (handbook) to make a quick-scan of the PPP potential of a TEN or other infrastructure project. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Membrane-ezrin-actin interactions mediated by ezrin binding proteins in reconstituted systems' (2014-2020).

assistant: **Innovation**

Microvilli are tube-like membrane protrusions containing bundles of actin filaments located at the apical surface of epithelial cells. A key component of these microvilli is ezrin, a member of the Ezrin/Radixin/Moesin protein family, which provides a regulated linkage between the plasma membrane and the actin cytoskeleton. The critical role of ezrin in microvillar morphogenesis has been demonstrated. However, how ezrin is recruited to the apical surface of the cells and how ezrin contributes to the stability of microvillar morphogenesis remain elusive. Recently, a few ezrin binding partners, such as EBP50 and Eps8, have been identified and shown to function synergistically with ezrin in membrane and actin remodelling in cells. The precise mechanisms and implications of their interactions in microvillar morphogenesis are not well understood. Lately, I-BAR domain protein IRSp53 was found to colocalize with ezrin in microvilli and interact with both EBP50 and Eps8, as ezrin does. Given that I-BAR domain proteins participate in the formation of many cellular protrusions, such as filopodia, ezrin and I-BAR domain proteins may work synergistically in membrane remodelling. The goal of this proposal is to better understand the interaction of ezrin, the membrane and actin, and the role of ezrin binding proteins and I-BAR domain proteins in this interaction by using reconstituted model systems based on purified proteins combined with supported lipid bilayers or giant unilamellar vesicles. In parallel, potential common binding partners of ezrin and I-BAR domain proteins will be identified, and their role in mediating the interaction of ezrin and I-BAR domain proteins on membranes will be studied. This project will thus lead to an improved understanding of the membrane and actin re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Elucidating the Structural Origin of NIR-Emission from Ag-DNA' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The interest in atomically precise metal cluster systems has grown over the last decades due to the physicochemical properties that emerge at the nanoscale compared to the bulk regime. Despite promising features, stability often hinders their use in real-life applications. Since stabilization is critical, DNA has been proven to be a functional and versatile scaffold for luminescent silver clusters. DNA oligomers are intrinsically biocompatible and are able to tune the emission color and promote high photoluminescence efficiencies.Near-infrared emitting DNA-stabilized silver nanoclusters (NIR-emitting Ag-DNAs) are promising candidates for several potential applications, such as bioimaging and sensing, due to improved cell and tissue penetration of NIR light. The development of NIR emissive Ag-DNAs currently needs to be improved by three main challenges: extremely limited structural information (only one is available), absence of a rationale for designing NIR-emitting Ag-DNAs with high luminescence yield, and poor understanding ofThis project aims to address these gaps by first synthesizing and screening a wealth of NIR-emitting Ag-DNAs and then employing state-of-the-art techniques, such as pair distribution function analysis and X-ray absorption spectroscopy, to characterize the best-performing candidates structurally. Establishing a structure-luminescence rationale for NIR-emitting Ag-DNAs will be the ultimate goal of the project. Such findings are paramount to performing electronic structure calculations, and it is the needed input for machine learning algorithms to predict NIR-emitting Ag-DNAs with tailored optical properties. The results of this proposal will thus pave the way for a myriad of different applications.


**Keywords:** DNA; metal clusters; X-ray absorpt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Traceability and Mutual Recognition of Impulse Voltage Measurements' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

ObjectivesThe main objectives are to promote mutual recognition and acceptance of reference measuring systems and calibration certificates and to develop and establish a generally accepted impulse/DC conversion for high-voltage measurements. Additional and more detailed objectives are to set up the scientific basis for mutual acceptance of high impulse voltage measurements within member countries as well as with other European and Non-European countries. In addition, the objective is to further develop the impulse voltage measurement and comparison techniques and to address difficult situations like testing with and measurements of full and front-chopped impulses superimposed with noise, oscillations and overshoot.State of progressThe progress of the work during the first period of six months was good. The Reference System was established and tested according to plans and even more. In some parts, the system is better than planned, e.g. impulse calibrators. The project homepage and related work by email appeared to be an effective way of communication. The circulating system is compact and a number of auxiliary equipment are circulated to improve the comparison measurements and to make them most effective. A comprehensive software for controlling the measurements and processing and saving the results is provided. The documentation is extensive and well beyond the original plans. The system was sent out for circulation in July 1999, two months before scheduled in the contract. However, some technical problems postponed the first comparison, and the circulation was re-started from USA after reparations and checks. Only three laboratories could complete their comparison measurements in 1999, because of considerable and unexpected problems in transports and customs declarat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Generation of therapeutic antibodies targeting type 2 Innate Lymphoid cells in asthma' (MInfla-Tilc), addressing dissemination and exploitation.

assistant: **Impact**

We are proposing to target Innate Lymphoid Cells 2 (ILC2s), a subset that has been frequently implicated in inflammatory diseases, such as severe asthma. ILC2s are major players in allergic asthma and are abundantly present as tissue resident cells in the lung, both in human and mouse. Strikingly, the induction of allergic asthma in a mouse model deficient in ILC2s is abolished. In addition, the transfer of ILC2s back in the same mouse recapitulates the pathology. Mechanistically, activated ILC2s are the main producer of type 2 cytokines that sustain the chronicity of asthma by recruiting other inflammatory and pathogenic cells, notably eosinophils, and finally drive hyperresponsiveness and mucous hypersecretion. In humans, ILC2s are increased in the peripheral blood mononuclear cells (PBMCs) of patients with allergic asthma compared to healthy controls. They are also found in sputum and PBMCs of patients with severe, eosinophilic asthma compared to mild forms of asthma. Collectively, these data highlight the significance of ILC2s in allergic inflammation and emphasize the idea to target those cells for therapeutic purposes. MInfla-Tilc is a translational and integrated project aiming to launch an innovative therapeutic monoclonal antibody (mAb) treatment against ILC2s to control severe asthma.