RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Developmental plasticity modulated by epigenetic processes such as methylation and post-translational modifications is influenced by early life events and determines risk of age related diseases later in lifeWe propose a multi-disciplinary approach incorporating biochemistry, genetics, epidemiology, epigenetics and bioinformatics to discover novel biomarkers of ageing and interventional pathways to reverse changes at an early stage. A consortium of 8 members including three SMEs leaders in genetics epigenetics, post-translational modifications and metabolomics will investigate plasticity in developmental changes at pre-natal, peri-natal and early life stages on ageing in three European cohorts with rich early life data and age-related health outcomes. The identical twin data which has extensive epigenetic, genetic and metabolomic data will be utilised as a “discovery” set and the other cohorts will be used for confirmation. This multi-disciplinary project will improve our understanding of the links between fetal or perinatal events and ageing process and by combining the latest technologies in genetics, epigenetics, metabolomics and post-translational modification technologies. It will allow to develop biomarkers of ageing that reflect the role of early development on ageing. Using the collective skills and experience of eight groups at the cutting edge of European genetic and ageing research this project will identify molecular biomarkers detectable in early life that can predict age-related health (or disease) outcomes and identify pathways for intervention that can be modified while changes are still reversible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SITless: Exercise Referral Schemes enhanced by Self-Management Strategies  to battle sedentary behaviour' in the context of a Horizon 2020 call.

assistant: **Objectives**

The increase of the elderly population leads to increased prevalence of frailty, risk for poor health outcomes, and related health and social care costs. Lack of physical activity (PA) and established sedentary behaviours (SB) constitute an additional burden, as they are related to progression of chronic disease and disabling conditions. An existing initiative to battle SB and insufficient PA levels are exercise referral schemes (ERS) implemented in primary care, where insufficiently active individuals are referred to a third party service (sports centre or leisure facility) that prescribes and monitors an exercise programme tailored to the patients’ needs. ERS had shown improvements in PA in the short-term, but may have limited power to change SB and produce long-term effects. Thus, ERS might be enhanced by self-management strategies (SMS) to promote behavioural change. Such strategies based on social cognitive theory have been shown to increase self-confidence, power to act, and involvement in exercise.In a first stage, a systematic review, focus groups and a feasibility study will be conducted. Then, a three-armed pragmatic randomized controlled trial (RCT) will assess the long-term effectiveness of a complex intervention on sedentary behaviour (SB) in an elderly population, based on existing ERS enhanced by self-management strategies (SMS). It will be compared to ERS alone and to general recommendations.The RCT will include 1138 subjects and will have a follow up of 18 months. The effect on SB will be measured as activity daily counts per minute and physical function. Secondary outcomes will include: healthcare use and costs, self-rated health and quality of life, mortality, morbidity, disability, institutionalization, mental health, social capital, sarcopenia and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification of drug-resistance genes for the development of effective combined therapies for melanoma' to be submitted under Seventh Framework.

assistant: **Abstract**

Malignant melanoma is a highly aggressive form of skin cancer with a poor outcome following metastatic spread. Chemotherapies for metastatic melanoma are rarely curative because of the emergence of clones from within the tumor that carry lesions in genes that confer therapeutic resistance. Understanding the genetic culprits of drug resistance will allow the rationale development of combination therapies that may circumvent the occurrence of resistance.Here I propose to combine different cutting-edge technologies and functional screenings in human early-passage melanoma cell cultures (EMCCs) to identify clinically relevant melanoma drug-resistance genes and consequently to develop new effective combination therapies by a data-driven approach.I will screen a library of drugs across a collection of EMCCs and in concert analyze the genome of each EMCC for mutations, epimutations and chromosomal aberrations. EMCCs found to be intrinsically resistant to a given drug will be screened with a short-hairpin-RNA library to identify genes whose knockdown reverts resistance. Those EMCCs sensitive to a given drug will be infected with lentiviral-vector based insertional mutagens to screen for genes whose upregulation mediates drug resistance, thus identifying mechanisms that may be associated with relapse in patients treated with these compounds. These 2 approaches will provide a collection of drug-resistance and -sensitivity genes that will be then validated in vitro, in vivo and in clinical samples.The knowledge of drug-resistance genes and genomic lesions carried by each EMCC will guide the design of new therapies based on the combination of multiple compounds targeting both the mutated gene and the EMCC-specific drug-resistance gene. The new combination regimens will be tested in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'bioREACtor for stem cell tHerapy' (REACH) targeting Seventh Framework.

assistant: **Abstract**

The REACH-project is a direct result of the FP7 StemExpand project, which aimed at the expansion and engraftment of hematopoietic and mesenchymal stem cells (MSC) for clinical use. The results of these research activities show that a novel, closed and controlled bioreactor can be developed to grow clinically relevant numbers (>400 million) of MSCs. XPand Biotechnology BV(NL) [bioreactor development, technology valorization], Aber Instruments ltd (UK)[biomass sensor] and PreSens Precision Sensing GmbH (GE) [DO, pH sensor] are three SMEs that have teamed up to develop this novel bioreactor system to a pre-commercial scale. The overall aim of the REACH project is to further develop and engineer the bioreactor (incl. valorization, testing and technical and biological validation) to a closed-system sensor-controlled bioreactor with sampling possibilities that allows for GMP-grade MSC production outside a cleanroom. The system will contain a disposable bioreactor bag with unique miniaturized disposable sensors. The DO and pH sensors use optical chemical methods capable of high frequency sampling, this ensures an enhanced stability of the expansion process. Using an expandable bioreactor the volume can be increased during cell culture, without the need for passaging of the cells. Because of this feature the system can be truly closed, without the limitations of a fixed culture substrate area. Leiden University Medical Center (NL) will validate the system and the products in a clinical setting by comparing bioreactor-expanded MSCs with GMP grade MSCs produced by established protocols in the LUMC. Successful development of this bioreactor system will be beneficial for the participating SMEs as well as the medical sector which will be able to develop cell therapies in a faster, c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advancing Mediterranean Forest Research Capacities' (AGORA) targeting Seventh Framework.

assistant: **Abstract**

In order to avoid an irreversible situation for Mediterranean forests in MPCs, a coordinated approach throughout the Mediterranean basin to improve forest management and policy-making based on reliable information and tools is required . AGORA will update and enlarged the scientific knowledge on the sustainable management of forests in selected MPCs through scientific cooperation and networking and targeted capacity building that uses efficiently the existing multidisciplinary knowledge and resources available in different European forest research institutions of the Mediterranean region. Coordinated forest research partnerships between “centres of excellence” (located in EU and an associated country) and MPCs entities with the highest research potential will be developed. This will be realised by improving scientific relationships, networking and exchanging of know-how and experience as well as by upgrading the research capacities of the MPCs forest research entities. In addition, the forest scientific strategies of the MPCs research entities' will be adjusted based on upgraded capacities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Protect Your Peerless Artwork with Innovative Nanoengineered Technology' in the context of a Horizon Europe call.

assistant: **Objectives**

The art market has always had to deal with an endemic problem: counterfeiting. All art is historically at risk of being copied and sold fraudulently by counterfeiters. A report by the Swiss Fine Art Expert Institute estimates that over half of all the artwork in circulation is fake. All this creates an incalculable loss of value for the entire market, including artists, auction houses, insurance companies and of course the end buyers, who often find themselves spending considerable sums of money only to end up with worthless pieces or even get into legal trouble. Works of art are generally not protected with dedicated security devices that uniquely identify the work itself. The problem historically originates from the requirement not to visibly alter the artwork itself and from the relative lack of security of existing non-invasive solutions.Our team at Politecnico di Milano aims to develop a printable new anti-counterfeiting system (PYPAINT) based on carbon-based nanostructures with a specific optoelectronic response, which makes it possible to create an artwork's unique identifier code that is invisible to the human eye. Thanks to the invisibility of inks, it is possible to print them directly on the artwork, or on a transparent label. The inks will be printed through an inkjet printer forming a pattern of spots able to create almost infinite codes readable using a special optical reader. Without the need for heavy metals or toxic compounds, PYPAINT is environmental-friendly. The verification of PYPAINT allows access to a remote database to guarantee not only its authenticity but also its history and relationship with the rest of the artist's works, creating a true digital reliable medium, available to the owner. It only takes a few seconds to identify and retrieve al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Kinetic selectivity in molecular sieve sensors' (KISSIES).

assistant: **Innovation**

Detecting and monitoring volatile organic compounds (VOCs) is an important task with applications ranging from disease diagnosis via breath analysis to monitoring exposure to toxic chemicals. However, in all such applications, selectively measuring specific VOCs is challenging due to their low concentrations and the presence of a multitude of interfering compounds. Since current miniature sensors cannot efficiently distinguish between VOCs, there is a need for a novel technology capable of distinguishing a VOC of interest from a complex background.KISSIES will address this challenge by bridging the worlds of porous crystalline materials and sensor technology. For the first time, kinetic selectivity in the tailored nanopores of metal-organic frameworks will be leveraged to mimic nature’s approach to olfaction and enable selective sensing. This way, KISSIES will not only enable cross-fertilization between research fields that have thus far been separated by traditional subject boundaries but also open up perspectives on solving unaddressed real-world challenges. Moreover, the novel methodology that will be developed will have an impact beyond the scope of the project, in domains such as separation technology and adsorption measurements.


**Keywords:** Metal-organic frameworks, Chemical sensors, Adsorption, Diffusion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Financing for Green Transition' in the context of a Horizon Europe call.

assistant: **Objectives**

As the signals of an ecological and climate crisis are intensifying.  The surface temperature of our planet is already around 1.2°C above pre industrial levels and is warming at an alarming rate. Against this,  researchers at the International Panel on Climate Change (IPCC), share with us their assessments that meeting the 1.5°C target is possible, and yet it will require ""deep emissions reductions” and ""rapid, far-reaching and unprecedented changes in all aspects of society."" The International Energy Agency calls to double the pace of energy efficiency progress towards green transition and notes that “large scale financing mechanisms ought to be enacted”. Often alluded as a “Tragedy of Horizon”, climate change related risks had been regarded as the problems of long durée, to be tackled by future generations, leaving little motivation for the current cohorts. But this is no longer the case. As the urgency of the anthropogenic climate crisis becomes more explicit, greening of the global financial system steps ahead in our agenda, central banks being no exception. In fact, pathways to a net zero emissions global economy are relatively well-studied and understood. Yet, many of these studies focused mostly on green transition of the power sector and decarbonization of the industry, while financing of this transition and, particularly the potential role of the central banks, is a relatively neglected area in the design of the green policy infrastructure. Thus, there is clearly an unavoidable need to deepen our knowledge on the design of a “green central bank”, that is, in the words of Dikau & Volz, 2018, a central bank that takes environmental risks including climate change into consideration in its actions. It is the purpose of this research consortium to study the poten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Upscale and redesign of a mobile harvesting and pelletizing disruptive all-in-one machine' (HarvPell).

assistant: **Innovation**

The EU is setting ambitious targets in terms of energy coverage by renewable energies with their 20-20-20 goals. Biomass is a major column to achieve these goals, but until 2020 a gap of 24-40Megatons of biomass was detected . In biomass plants pellets can be burned and heat and / or electricity for further use can be produced. Pellet production is becoming a world market with Europe as a central player as within EU27 countries 50% of the pellets are produced and 70% are consumed (11 and 15.1 million tons per year respectively). Producing pellets is a various step process, which includes works on the field (mowing, collecting), transportation and pelletizing. Mobile pelletizers have been brought to the market by Agro Bio Tech, PCM Green Energy or Bauer and Krone has planned one for 2018 but none of the competitor products offers an all-in-one solution, which integrates all necessary steps for producing pellets from the field to ready to use pellets (figure 1).SCM will revolutionize the market by offering a self-driving all-in-one machine, our PELLESTER, that unifies all necessary process steps for harvesting and pelletizing:- The PELLESTER reduces transportation cost for pre-pelletizing by 100%; - It provides a 1 to 16 times higher throughput than that offered by competitors;- Specific pelletizing cost are less than 25€/t (>70% lower than competing systems);- It comprises a remote control, high level of automization and advanced self-learning software. SCM will provide farmers, farm cooperatives and machinery contractors with our PELLESTER a mobile harvester that enables cost-efficient pellet production in a single operation directly in the field. This project, HarvPell, will directly create 57.5million € and 115 new jobs until 2022.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Fundamentals and applictions of laser processing for highly innovative MOS technology'.

assistant: **Objectives**

The FLASH project is intended to provide leading-edge European contributions to the priority topic of processes and equipment for the 70 nm CMOS technology. This task will be pursued by studying the feasibility of the excimer laser annealing process and its integration with advanced device processing. The extensive theoretical and experimental work, proposed on the use of laser for the fabrication of semiconductor devices, will have a decisive role in the development of nano-technology. The network formed to run the project has been designed to assure European exploitation paths within the semiconductor industry. The project FLASH intends also to set up reliable simulation software, able to reproduce the effects generated by the interaction of the laser beam with device structures and doped layers. The project aims to go beyond the state of the art technology in order to provide a breakthrough in the integrated circuits scenario. The FLASH project is intended to provide leading-edge European contributions to the priority topic of processes and equipment for the 70 nm CMOS technology. This task will be pursued by studying the feasibility of the excimer laser annealing process and its integration with advanced device processing. The extensive theoretical and experimental work, proposed on the use of laser for the fabrication of semiconductor devices, will have a decisive role in the development of nano-technology. The network formed to run the project has been designed to assure European exploitation paths within the semiconductor industry. The project FLASH intends also to set up reliable simulation software, able to reproduce the effects generated by the interaction of the laser beam with device structures and doped layers. The project aims to go beyond the state of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Optical device to measure the density of the macular pigment in the human eye'.

assistant: **Innovation**

Age-related macular degeneration (AMD) is a leading cause of blindness in Europe. Since there is a lack of effective treatment modalities, prevention is of signficant importance. There are some evidences that nutritional counseling or intervention might reduce AMD incidence or slow down its progression. In particular, dietary modification or supplement intake may facilitate the increase of the retinal carotenoids lutein (L) and zeaxanthin (Z) that form the macular pigment (MP) and prevent neovascular age-related macular degeneration. In such supplement treatments and follow-ups, regular MP density (MPD) measurements should be essential. Until today, instruments capable of measuring MPD are either psychophysical requiring the subjective responses of the patients (operating on variants of heterochromatic flicker photometry) or are advanced imaging devices that record hyperspectral images of the macula and surrounding areas of the retina. In these instruments, MPD is derived by the relative absorption of the blue part of the spectrum that is characteristic to the absorption spectrum of MP. These instruments are either difficult to use or very expensive. Within the SeeCat-ERC Advanced Grant project, we developed a completely new optical approach to measure and map the MPD. It is practical, compact, cost effective, and can be operated without extensive training and maintenance. In this PoC project (OpMaEye), we aim to further develop the instrument by designing a working compact prototype and performing initial validations.