RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Inverse Design of Optoelectronic Phosphosulfides'.

assistant: **Concept**

Progress in sustainable energy technology relies on the discovery of new earth-abundant materials with unprecedented ability to conduct ions, catalyze reactions, transport photogenerated carriers, etc. The main scientific question is how to find the materials with exactly the desired functionality from the huge pool of all possible materials (more than 10^12).In IDOL, we will attempt to answer the long-standing question of inverse materials design. Our targeted functionality is high optoelectronic quality (i.e., long photocarrier lifetimes, high mobilities, and high absorption coefficient) in an earth-abundant semiconductor with band gap above 1.5 eV. This will be a breakthrough in three areas key to a sustainable energy future: multijunction photovoltaics, light-emitting diodes, and solar fuels.The IDOL approach is a combination of experimental and computational research, focusing on the most device-relevant material form: thin films. Initially, we will restrict our search to the intriguing and still highly underexplored family of phosphosulfides (PSs). Later, we will extend our insights to other chemistries. From my preliminary investigation, many PSs should exhibit high mobilities and appropriate band gaps.We will break the inverse design problem into logically connected steps: from application-specific figures of merit, going back to defect properties, generic optoelectronic properties, structure, growth conditions, and composition. We will exploit a unique combinatorial deposition system to grow candidate materials and characterize them using high throughput facilities at our host. For properties not experimentally accessible, we will employ first-principles calculations. This hybrid dataset will be analyzed step-by-step by human intelligence and machine learning t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Policy Compass' to be submitted under Seventh Framework.

assistant: **Abstract**

The main goal of the project is to develop a research prototype of an easy-to-use, highly visual and intuitive tool for social networks and e-participation platforms, called the Policy Compass, enabling citizens and public officials to easily create, apply, share, embed, annotate and discuss causal models, charts and graphs of historical data from trusted open data sources. The aim is to develop methods and tools that facilitate more factual, evidence-based, transparent and accountable policy evaluation and analysis.The research question we want to address in the Policy Compass project is whether and how open public data, social media, e-participation platforms, fuzzy cognitive maps and argumentation technology can be integrated and applied to provide better tools on the World-Wide Web for constructing, sharing, visualising and debating progress metrics and causal models of policies.The Policy Compass will make better use of Europe's open public data resources and empower policy-makers and citizens (especially the younger generation) to better assess government policies in the policy analysis and monitoring phases of the policy cycle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pathogenesis of classical swine fever; towards rapid immunodiagnostic detection of infected animals' under Fourth Framework.

assistant: **Concept**

Classical swine fever (CSF) is an economically important, often fatal, highly contagious disease of Suidae. The causative agent - CSFV - is a member of the genus Pestivirus, family Flaviviridae, along with bovine viral diarrhoea and border disease viruses. It is an OIE List A virus, the disease having been described as the most devastating disease of pigs. This lest description is clearly evident from the situation of CSF in the EU during the first two months of 1997, with thousands of pigs having to be slaughtered in Germany, Holland and Italy, plus the concomitant trace restrictions which follow. Experimentation in vivo has identified haematological changes, in particular peripheral blood lymphocyte depletion, and mobilisation of immature granulocytes. These are detectable before virus infection of blood celle, indicating that the pathological mechanisms are not a direct consequence of virus infection: lymphocyte depletion was noted as early as one day p.i. with virulent CSFV, whereas virus infection was not clearly detectable before 7 days p.i., and seroconversion even later.  Based on the evidence currently available, the hypothesis is that the pathogenesis of CSF involves tissue destruction and cell death, induced, at least in part, by the modulation of monocyte/macrophage factors and cellular activity.  The objective of the project is to relate the activity of the infected cells to the form of leukocyte compromisation identified, particularly in terms of prograrnmed cell death and modulation of differentiation/maturation. Therein, the role of leukocyte factors would be studied, in terms of their roles as soluble mediators of immunological function and signalling. From this work, it is envisagea that a clearer picture of the characteristics of the immunopathology o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Oncogenic competence during development –  When, Where and Why?' (ONCO-COMP) under Horizon Europe.

assistant: **Objectives**

Childhood cancers are believed to be rooted in aberrant development, a notion supported by their (i) generally low mutational burden, (ii) high prevalence of single (often epigenetic) driver events and (iii) occurrence during confined developmental periods. Yet, the exact origins of developmental tumours remain one of the principal enigmas of pediatric oncology. A prime example are malignant rhabdoid tumours (MRTs): they are astoundingly genomically simple but extremely deadly childhood cancers that arise almost exclusively in the first two years of life, and are driven by biallelic inactivation of the SWI/SNF chromatin remodelling complex subunit SMARCB1 (>95% of cases). We still do not know what determines oncogenic competence upon SMARCB1 loss. In particular we wonder: (1) What are the cell(s)-of-origin of rhabdoid tumours and what is their normal differentiation potential? (2) What is the molecular framework that facilitates oncogenic transformation upon SMARCB1 loss? (3) What is the contribution of the niche (local and systemic) to the acquisition of oncogenic competence? And, considering the epigenetic nature of the oncogenic event, (4) is the oncogenic MRT state reversible, and how?To answer these questions, we will combine state-of-the-art lineage-barcoded single-cell genomics, spatial transcriptomics, single-cell resolution wholemount imaging, CRISPR/Cas9 and epigenomic approaches, as well as integrative computational analyses, using transgenic mouse, induced pluripotent stem cell and patient-derived xenograft rhabdoid tumour models.This project will provide fundamental insights into the cell autonomous and non-autonomous determinants of oncogenic competence upon SMARCB1 loss. Based on our findings we hope to unlock targeted treatments for MRT patients. Importa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainable production of apple and pear in asia: understanding biology of scab and powdery mildew for developing integrated approaches of disease management' to be submitted under Fifth Framework.

assistant: **Abstract**

Apple and pear are priority cash crops in Asia and their production depends on sustainable control of apple/pear scab and apple mildew. This project will provide knowledge to develop integrated approaches for disease management. Effects of weather factors on pear scab will be studied in controlled environment; a forecasting model will be developed and validated by field data. Field epidemics of apple scab/mildew will be recorded to modify European forecasting models for use in Asia. Population variations of apple scab/mildew will be quantified using molecular markers and new virulence will be identified to assist in breeding cultivars with durable resistance and in deploying cultivars. Population variation of Ampelomyces quisqualis, a parasite of mildews, will be studied using molecular techniques and its interaction with mildew will be quantified. Biocontrol potential of selected isolates will be assessed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A revolutionary Lithography-based Metal Manufacturing (LMM) machine for 3D printing of high-quality functional metal parts' (LMM), addressing dissemination and exploitation.

assistant: **Impact**

The typical use of Additive Manufacturing (AM) for metals is to produce prototypes during product development and complex parts for pilot series. Whereas established industrial methods such as Metal Injection Molding (MIM) are used for the production of complex metal parts in high volumes. The design limitations and high tooling costs for casting or injection moulding also make conventional manufacturing unsuitable for customizable short series production of parts with high geometric complexity. AM is expected to address this need by speeding the production time without inflating the costs per part especially for applications such as dental restoration, aerospace, and automobiles. Despite a large need, high set-up costs, lengthy manual post-processing and unpredictable defects in final parts and products are preventing complete deployment and adoption of AM in the manufacturing of final products. Lithoz offers Lithography-based Metal Manufacturing (LMM), an innovative automated AM machine for 3D printing of advanced, high-quality metal products. Thanks to a proprietary ground-breaking AM technology, LMM enables to print any metal parts with any design and provides unequaled accuracy and quality of the final product. LMM can be easily implemented into existing Metal Injection Moulding (MIM) manufacturing lines without the need for dedicated postprocessing machinery and specialized expertise, thus enabling to reduce total production costs and time. During the phase 1 feasibility study, Lithoz will establish a sound go-to-market strategy and supply chain and will outline further development plans. During the innovation project, Lithoz will optimize the machine and printing process, validate it with partners in the MIM manufacturing industry, and obtain CE mark and regulato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metabolism of resveratrol and its hydroxymetabolites - impact on their anticancer properties', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Breast cancer is the major cause of cancer death in women worldwide, however significant geographical differences in morbidity can be observed. Studies of migrant populations have indicated that the genetic background only plays a tiny, if any, role in differences in breast cancer morbidity. The lower incidence of breast cancer in Asian population was associated with diet contents phytoestrogens.Their potential health benefits include protection against hormone-dependent cancer, cardiovascular disease and osteoporosis. Resveratrol (3,4',5-trihydroxystilbene) has attracted considerable attention because its presence in diet and its wide spectrum of biological activity including antioxidative, antiplatelet, antifungal, phytoestrogenic, cardioprotective properties. Because of its structural similarity to diethylstilbestrol resveratrol can act as phytoestrogen. Many authors proposed this mechanism as explanation its action against breast cancer cells.Moreover resveratrol acts as growth inhibitor of estrogen-independent cell lines. Piceatannol (3,3'4'5 trihydroxystilbene) is naturally occurring analog of resveratrol and as well as resveratrol has been classified as a phytoalexin. Many reports show that piceatannol interferes with neoplastic growth by modifying multiple cellular targets. While effects of resveratrol and piceatannol are well studied in various in vitro and animal models, up to now, little is known about their higher hydroxy analogs. Some findings suggest that they may be formed as the metabolites of resveratrol and piceatannol.The main aims of this proposal are: estimation of cytotoxicity and apoptosis induction in estrogen receptor positive, negative and genetically transfected breast cancer cell lines by resveratrol analogs and investigation of metabolism of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Transformation of Jewish Literature in Arabic in the Islamicate World'.

assistant: **Innovation**

In pre-modern times, an estimated ninety percent of the Jewish population lived under Muslim hegemony. Over the centuries, these Jews not only adopted the Arabic language for most forms of spoken and written communication, but also integrated concepts and techniques from their intellectual environment, resulting in one of the most extraordinary periods of literary creativity in all of Jewish history. Despite its importance, however, Judaeo-Arabic literature has been under-researched until very recently, due to inaccessible sources, disparate scholarly traditions and political antagonism.The overall aim of MAJLIS is to explore comprehensively for the first time the fundamental way in which the adoption of Arabic transformed Jewish literature from the 9th to the 11th century. The project focuses on the Arabic literature of the Qaraites, a Jewish intellectual movement whose religious and scholarly center, the Academy of Jerusalem, played a catalytic role in these transformation processes. It will proceed by applying state-of-the-art digital tools to analyze manuscripts produced in the Academy with the aim of (1) tracing changes in Jewish literature and contrasting them to rabbinic literary models, especially with regard to how the texts were composed, produced, authored, and organized into a knowledge framework; (2) identifying the dominant scholars and analyzing their geographical origins, professional networks and institutional integration; and (3) comparing the Academy and its literature to non-Jewish literature and non-Jewish institutions of the time.By bringing together unique expertise covering Judaic as well as Islamic studies at a time when the sources have become available to an unprecedented degree, MAJLIS will not only fundamentally add to our understanding of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Decoding and perturbing cell identity regulatory network for cell fate and state engineering' (DECIPHER).

assistant: **Concept**

Human cells engineered in vitro have revolutionized our ability to model human biology and diseases, offering exciting opportunities for therapeutic screening and intervention. However, single-cell transcriptomics (scRNA-seq) reveals that engineered cells often remain heterogeneous, immature, and dissimilar to primary counterparts. Precise cell engineering remains challenging without systematic interrogation of gene regulatory networks (GRNs) that establish cell identity. Here, we propose to engineer precise cell fates and states by coupling GRN decoding, perturbation screening, and single-cell technologies. Our vision is to decode GRNs that shape cell identities in fate specification, multicellular communication, and maturation, and use this insight to 1) engineer precise cell subtypes, 2) reconstruct niche-specific signatures, and 3) accelerate maturation. Using human induced pluripotent stem cell (iPSC)-derived neural cells, we will first couple combinatorial transcription factor screening with scRNA-seq to directly induce iPSCs into specific neuron subtypes guided by primary neuron GRNs. Second, we will program glial cell subtypes and reconstruct multi-cellular niche with neurons, analyze how niche cross-talk impacts cell fates and states, and use emerged GRNs to engineer niche-specific signatures. Finally, we will decode dynamic GRNs during neural maturation and screen for determinants to accelerate maturation. DECIPHER aims to dissect the causal links between GRNs and cell identities, offering mechanistic insights into drivers of cell identity changes with the ambitious goals to engineer precise and mature cell subtypes for disease modeling, cell therapy, and regenerative medicine. Our approach holds great potential to study diverse cell fate and state transition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Scalable, Tunable and Resilient Optical Networks Guaranteeing Extremely-high Speed Transport' to be submitted under Seventh Framework.

assistant: **Abstract**

Internet traffic has been growing quickly for many years, despite adverse economic conditions and this growth will continue in the future. To cope with this evolution, the cost of today's network solutions is still too high.In addition, in line with the EC goal of reducing the overall emissions, energy efficiency should be widely improved, using whenever possible optics instead of electronics where only transport is required.Moreover, due to the unpredictable traffic increase, flexible bandwidth management has to be used instead of fixed allocated bandwidth.For these reasons, the key requirements of innovative ultra-high bandwidth networks refer to scalability, flexibility, assurance of end-to-end quality of service and energy efficiency, beside reduction of total cost of ownership.In the data plane, current equipment and network architectures still provide limited scalability, are not cost-effective and do not properly guarantee end-to-end quality of service.In the control plane, the open issue is to define an end-to-end control structure that allows different technologies and domains to inter-work efficiently, incorporating virtualization of network resources.Based on these rationales, STRONGEST's main objective is:To design and demonstrate an evolutionary ultra-high capacity multilayer transport network, compatible with Gbit/s access rates, based on optimized integration of Optical and Packet nodes, and equipped with a multi-domain, multi-technology control plane. This network will offer:High scalability and flexibilityGuaranteed end-to-end performance and survivabilityIncreased energy efficiencyReduced total cost of ownershipFeasibility studies and experimental implementation and demonstration of prototypes will be key activities, as well.STRONGEST will also feed th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'MAC and Network Layers Optimization'.

assistant: **Innovation**

The High Speed Downlink Packet Access (HSDPA) has been introduced in order to improve the downlink capability by the third Generation Partnership Project (3GPP) in the Wide-band Code Division Multiple Access (WCDMA) standard. Due to the increasing demands for uplink intensive data services such as ftp and multimedia uploads etc., the concept of the High Speed Uplink Packet Access (HSUPA) was subsequently introduced.  Together, these downlink and uplink technologies are collectively known as the High Speed Packet Access (HSPA) for short.  One of the most important item which distinguish HSPA from earlier versions of the WCDMA standard is the migration of some of the Medium Access Control (MAC) functionalities from the Radio Network Control (RNC) to the base station (Node-B). Such a change enables new techniques to be introduced, allowing faster adaptation to the current radio environment as well as traffic conditions. Also, it allows more efficient multi-user scheduling algorithms to be developed. While the many researches on scheduling have focused on the HSDPA, relatively fewer results have been reported for the HSUPA.  However, there can be various factors at the network level which might influence the behaviours of the schedulers.  These factors include the traffic load of the system, the number of users belonging to different priority classes, as well as interference levels, etc. To make the matter worse, these influencing factors are time-varying.  Thus, the network must be able to adapt such changes in order to operate optimally.   The objectives of this project are to investigate the potential factors at the network level which might influence the behaviours of the scheduling at the MAC layer, and develop cross-layer algorithms between the network and the MAC lay