RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrochemical biosensors as new generation of biotechnological devices for food safety and quality monitoring' in the context of a Seventh Framework call.

assistant: **Objectives**

In the past decade, the development of biological ligands as alternative candidates to classical devices has enabled rapid advances in many analytical fields. The Research will focus on the development of a new generation of electrochemical biosensors for food safety and quality monitoring. The approach of the project will be oriented to test the performances of enzymes or antibodies versus new computationally-designed biomimetic ligands which work by mimicking the biological binding site. Choosing a ligand to achieve some desired structure is still largely a subject of trial and error. The key point of this research will be taking advantage of molecular modelling software to obtain candidates with the purpose of reducing by orders of magnitude the efforts to obtain specific receptors.  The biological and biomimetic ligands will be coupled with electrochemical transducers that are known to give fast, reproducible and sensitive analytical responses often in real time. Disposable, screen-printed electrodes will be employed for electrochemical transduction. These new electrodes present some advantages i.e. advantage of low cost production, the possibility of employing brand new surfaces with each analyzed sample and the possibility to be coupled with portable devices performing very modern and sensitive electrochemical techniques. This approach is promising to produce inexpensive, biotechnological devices to be used in food safety and quality monitoring by combining the selectivity of biological or biomimetic ligands with the powerful properties of electrochemical techniques. All important analytical parameters i.e. reproducibility, sensitivity, selectivity, stability, etc, will be studied first using standards and, after optimization of the protocol, in real samples. As a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Delivery of Small RNAs by Functional Hydrogel Nanoparticles to Improve Osmotic strEss Tolerance in Plants' (DAFNE).

assistant: **Innovation**

RNA interference is a potent technology largely employed to trigger gene silencing and control specific biological processes. Thedelivery of small RNA is one of the most intriguing challenges in RNAi technology. Smart nanomaterials for safe and effective RNAdelivery have been successfully exploited in animals, while a limited number of applications have been proposed in plants so far. Thepresent project aims to develop and to validate smart hydrogel for small RNA (siRNA and miRNA) delivery able to knock down theexpression of selected genes and ultimately promote osmotic stress tolerance in plants. To achieve these objectives, naturalhydrogels such as dextran, poly(ethylene glycol), chitosan and alginate will be synthesised and functionalised with small RNAs inorder to obtain nanomaterials with unique properties. Hydrogels will be applied to plant leaves and roots, both in vitro and in vivo. Asproof of concept, DAFNE will target control genes such as phytoene desaturase (PDS) and green fluorescent protein (GFP) in themodel species Arabidopis thaliana, whose knockdown phenotypes are well-known and easily detected. Subsequently, functionalhydrogels will deliver stress-related miRNAs in order to develop drought tolerant plants in A. thaliana and in a representative foodcrop Solanum tuberosum.Merging distinct expertise, DAFNE will offer the candidate researcher multidisciplinary training in the field of plant biology andgenetics, as well as in molecular and cell biology, which will expand her skills, currently based on chemical engineering.


**Keywords:** RNAi, Plant Genetics, Climate Changes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Photochemistry, ultrafast dynamics and diagnostic applications of the III generation photosensitizers' under Sixth Framework.

assistant: **Concept**

The goal of the project is to reach excellence in research on molecular diagnostics by laser methods in Europe and to set-up an unique integrated Network between the single-investigator laser facilities at European Universities and the large-scale national laboratories for research/training/and teaching on laser technology and applications to contribute to structuring the European research. The present project within the Marie Curie Chair pursues the following specific objectives: 1) to integrate state-of -the-art laser technology, Raman spectroscopy and research in molecular spectral diagnostics for medical purposes, 2) to provide scientific results that can be useful in the design of new compounds with an enhanced tumoricidal activity in phototherapies and medical diagnostics, 3) to develop methods of spectral diagnosis for in vivo analysis of medical samples such as blood or breast tissue. The project will give contribution to reach a final goal of screening and monitoring cancer cells through Ram an blood test, 4) to increase the visibility and attractiveness of European research and training in the laser-oriented fields, 5) to encourage more female scientists to join a laser-oriented research. To achieve the defined objectives multi-national a nd cross discisplinary joint research activities and networking activities are proposed. Expected impact of the project will be obtained by: 1) establishing the Marie Curie Chair in multinational and cross disciplinary environment. The MBI (host organization) is the coordinator of the I3 programme Laser-Lab (17 laser national laboratories from 9 countries), 2) creation by the Chair of European Virtual University on Lasers, 3) enhancing public awareness of the links between the spectacular developments in laser technologies an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Understanding and Exploiting Biological Catalysts for Energy Cycling: Development of Infrared Spectroelectrochemistry for Studying Intermediates in Metalloenzyme Catalysis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Advanced catalysts for energy cycling will be essential to a future sustainable energy economy. Interconversion of water and hydrogen allows solar and other  green  electricity to be stored in transportable form as H2 - a fuel for electricity generation on demand. Precious metals (Pt) are the best catalysts currently available for H2 oxidation in fuel cells. In contrast, readily available Ni/Fe form the catalytic centres of robust enzymes used by micro-organisms to oxidise or produce H2 selectively, at rates rivalling platinum. Metalloenzymes also efficiently catalyse redox reactions of the nitrogen and carbon cycles. Electrochemistry of enzyme films on a graphite electrode provides a direct route to studying and exploiting biocatalysis, for example a fuel cell that produces electricity from dilute H2 in air using an electrode modified with hydrogenase. Understanding structures and complex chemistry of enzyme active sites is now an important challenge that underpins exploitation of enzymes and design of future catalysts. This project develops sensitive IR methods for metalloenzymes on conducting surfaces or particles. Ligands with strong InfraRed vibrational signatures (CO, CN-) are exploited as probes of active site chemistry for hydrogenases and carbon-cycling enzymes. The proposal unites physical techniques (surface vibrational spectroscopy, electrochemistry), microbiology (mutagenesis, microbial energy cycling), inorganic chemistry (reactions at unusual organometallic centres) and technology development (energy-catalysis) in addressing enzyme chemistry. Understanding the basis for the extreme catalytic selectivity of enzymes will contribute to knowledge of biological energy cycling and provide inspiration for new catalysts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LEArning-Driven and Evolved Radio for 6G Communication Systems' (6G-LEADER).

assistant: **Concept**

6G-LEADER aims at evolving the PHY and RAN aspects of 6G communication networks by relying on the following pillars: 1) ML-empowered PHY algorithms with predictive capabilities towards fully autonomous operation; 2) full-duplex transceivers employing novel sparse antenna arrays and advanced digital self-interference cancellation; 3) non-orthogonal and random multiple access schemes to accommodate mass connectivity demands of users and machines; 4) goal-oriented semantic communications; and 5) an open and disaggregated RAN  implementation with xApps integrating the advancements, achieved during the project’s lifetime.


**Keywords:** 6G, physical layer, fluid antennas, semantic communications, channel prediction, conflict management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'StudioLab - a new European platform for creative interactions between art and science' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Inspired by the merging of the artist’s studio with the research lab to create a hybrid creative space, STUDIOLAB proposes the creation of a new European platform for creative interactions between art and science. STUDIOLAB brings together major players in scientific research with centres of excellence in the arts and experimental design and leverages the existence of a new network of “hybrid” spaces to pilot a series of projects at the interface between art and science including Le Laboratoire (Paris), Science Gallery (Trinity College Dublin), Royal College of Art (London), Ars Electronica (Linz) and MediaLab Prado (Madrid) and STUDIOLAB will involve activities along three key dimensions: incubation of art-science projects, education and public engagement.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cooperative and opportunistic communications in Wireless Networks', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Cooperation and opportunism are two concepts that have recently revolutionized the way engineers think about wireless system design. Both have their origin at information theoretic studies and target the maximization of the spectral and power efficiency at the system level. Successful incorporation of these concepts in wireless system standards requires the solution of difficult theoretical and practical problems. Consequently, these concepts are expected to be long-term research topics of fundamental nature in the communications area.We plan to:1. explore performance limits of cooperative and opportunistic schemes (e.g., information theoretic analysis of combined cooperative-opportunistic schemes, large system analysis for gain quantification of cooperative schemes) and multi-user diversity with limited feedback;2. develop efficient strategies and coding schemes for cooperative and opportunistic communications, maximizing diversity and coding gain under various operational scenarios (homogeneous versus inhomogeneous channel statistics, full versus partial channel knowledge, codes for a combined cooperative-opportunistic scenario);3. develop efficient resource allocation with limited feedback, including decentralized resource allocation, by targeting the optimal exploitation of various grades of channel information at the transmitters (full, partial, statistical);4. implement selected cooperative and opportunistic schemes on a test-bed, in order to fully understand practical implementation constraints, assess the benefits of cooperation and opportunism in realistic environments, and support proof-of-concept.The goal is to attain an order of magnitude higher aggregate data rates than what is currently envisioned in 4G research, while supporting much tighter QoS guarantee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Restoration of the gut microbiome after delivery by caesarean section to prevent asthma' (RestoreGut) targeting Horizon Europe.

assistant: **Abstract**

Associations between caesarean section (CS) and childhood asthma may be mediated through microbial changes. In 700 children followed prospectively from birth, I recently showed that microbial perturbations after delivery by CS explain the delivery mode-associated risk of developing asthma in the first 6 years of life. CS was associated with more than a doubled risk of later asthma and allergic sensitization as well as immense compositional changes in the gut microbiota. An increased asthma risk was only found in children born by caesarean section, if their microbiome did not normalize by age 1 year, suggesting that a healthy microbial maturation can alleviate the childs increased asthma risk.Under the hypothesis that asthma risk from CS can be avoided by restoring the early gut microbiome, the proposed project will identify key environmental, dietary and host factors that help restoring a CS perturbed microbiome, map the compositional and functional potential of the CS microbial profiles, evaluate the role of the virome in the CS associations and perform co-cultures of key microbial consortia that may restore a healthy trajectory. Finally, I will perform murine experimental models to validate the findings and perform pilot studies on CS microbiota restoration by fecal microbiota transplantation (FMT) and fecal virome transplantation (FVT) in newborns.This will be a truly translational research project, with the potential to go from clinical observations to mechanisms based on bioinformatics and microbiological laboratory work and experimental models and a pilot human trial to infer causal relationships with the perspective of developing a potential future intervention strategy.If successful, this strategy will be groundbreaking for understanding the microbiomes role in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Glycomic and Genomic Repercussion of Nebulisable Gal-3 Inhibitory Medical Device Treatment in Pulmonary Fibrosis' under Horizon 2020.

assistant: **Concept**

Idiopathic Pulmonary Fibrosis (IPF) accounts for a progressive pathology with extremely high mortality and no cure available. There is a need to study pathology mechanisms for efficient treatments development. Galectin-3 (Gal-3) has shown promising effects in slowing down IPF. In this project, I will optimise nebulisation of a novel Gal-3 inhibitory drug (TD139) hydrogel treatment in bleomycin-induced PF mice model, perform an exhaustive genomic analysis to assess single-cell RNA trajectories during pathology recovery, and analyse tissue glycosylation patters for disease correlation. All this will allow for information on diseases and healing mechanisms to development efficient biomaterials treatments and contribute to the 3rd Sustainable Development Goal of the United Nations “Good Health and Well-Being” for all. I will perform nebulisation studies during secondment in specialised aerosol drug delivery industry (Aerogen®/John Power) (Ireland), in vivo model and exhaustive genomic analysis during outgoing phase in IPF genomic expert lab (Prof Kaminski) at PCCSM, Yale School of Medicine (US), and thorough lectin microarray analysis during incoming phase in glycolbiologist and biomaterials expert lab (Prof Pandit) at CÚRAM, NUI Galway (Ireland). The high expertise of the supervisors, my expertise in biomaterials, the highly qualified and prestigious hosts infrastructures and the intersectoral, international and interdisciplinary aspects of the action will promote my skills for eligibility for the EU Research Council Starting Grant. This will allow me to stablish a Biomaterial Therapies Critical Mass for Respiratory Diseases (RD) in EU and comply with the EU Respiratory Society objective to promote scientific excellence to alleviate suffering of RD. In addition, I will wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Establishing a global observational view of the early stages of planet formation and evolution'.

assistant: **Concept**

Recent observing campaigns have revealed a great diversity in exoplanetary systems whose origin is yet to be understood. How and when planets form, and how they evolve and interact with their birth environment, the protoplanetary disks, are major open questions. Protoplanetary disks evolve and dissipate rapidly while planets are forming, implying a direct feedback between the processes of planet formation and disk evolution. Observing protoplanets still in the early stages of formation and studying their imprints on the disk structure is therefore crucial.PROTOPLANETS aims to establish a global observational picture of the early stages of planetary systems formation and evolution. My team and I will analyze cutting-edge observations on a large sample of protoplanetary disks, calibrated with novel data processing technics and modelled in the light of state-of-the-art simulations, to:(1) search for giant protoplanets still embedded in disks;(2) study the imprints of planet-disk interactions and their dependence on stellar/disk properties;(3) reveal the impact of planets on the disk structure and dust evolution;(4) determine the conditions for terrestrial planet formation in the inner disk regions.The overall ambition of PROTOPLANETS is to understand the diversity of exoplanetary systems by linking the properties of protoplanets with those of the inner and outer disk regions. The project builds on a novel methodology to detect giant protoplanets and at the same time, characterize the birth environment shaped by those planets. As demonstrated by our recent discovery of the first protoplanet imaged in a disk, the direct detection and characterization of protoplanets will be a major breakthrough, enabling probing of processes of planet formation that could only be addressed t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Network-Aware P2P-TV Application over Wise Networks' (NAPA-WINE), addressing dissemination and exploitation.

assistant: **Impact**

In the next few years we will assist to the explosion of the market of high quality video distribution over Internet (IPTV). The massive deployment of IPTV platforms will offer the opportunity to change the paradigm of current TV broadcasting, moving from the nowadays mass TV, toward personalized TV, thanks to the creation of a large number of thematic channels.<br/> IPTV services can be provided either exploiting IP multicast functionalities or relying on a pure end-to-end (P2P) approach. The first approach can be typically supplied only on a closed network infrastructure controlled by a single broadband operator. On the contrary, P2P approach has been successfully exploited to overcome these limits and potentially offer a scalable planetary infrastructure.  On the other hand P2P-TV systems constitute also a fear for the current network carriers since the traffic they ingenerate may potentially grow without control, causing a strong degradation of quality of service perceived by Internet users or even the network collapse (and consequent failure of the P2P-TV service itself).<br/>Starting from these considerations this project is aimed: <br/>i)\tat providing a careful analysis of the impact that a large deployment of both general P2P-TV services may have on Internet, through an in deep characterization of traffic they generate;<br/>ii)\tat providing suggestions for P2P-TV developers regarding the design of systems that minimize the impact on the underlying transport network while optimizing the user perceived quality<br/>iii)\tat providing suggestions for Internet Providers by showing simple and minimum cost actions that can be taken to better exploit the network bandwidth in presence of P2P-TV traffic.<br/>A software library containing many of the  algorithms studied