RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Understanding the influence of human and organizational factors on surgeon performance to enhance patient outcomes: experimental evaluation of a customized coaching program' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Individual performance of surgeon is a core element of successful surgery that can vary greatly over career for poorly understood reasons. Solutions to optimize physical and mental condition of surgeon during operation have not been thoroughly explored so far, while this may represent basic foundation for delivering high quality surgery. This surgeon-centred outcome research pursues three successive goals: 1-Identifying the key determinants related to surgeon's human factor and operating room organization influencing his/her performance in terms of patient safety and care efficiency; 2-Developing a customized coaching program for surgeons based on the human and organizational factors previously discovered, which includes a charting system for individual parameters and surgical outcomes feedback, profiling of individual surgeon, and standardized modules of improvement; 3-Implementing and measuring the impact of this program on surgical outcomes of a randomized group of surgeons against a control group of non-exposed surgeons. Inspired from previous experiences in the aeronautic and sport arena to improve pilots and athletes performance, our approach will take place in real time at the point of care in close collaboration with front-line personnel. A particular attention will be paid to quantify the influence of several factors that may affect how the surgeon operates every day (physiological stress, sleep quality, physical activities, workload, team composition and unplanned events in operating room). Generated knowledge on these factors will be exploited for identifying deficiencies that, if corrected, could improve surgeon's functional capacity. Solutions to control these factors and achieve optimal outcomes will then be experimentally tested to establish evidence-base
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Microrobotics and Nanomedicine'.

assistant: **Concept**

The introduction of minimally invasive surgery in the 1980’s created a paradigm shift in surgical procedures. Health care is now in a position to make a more dramatic leap by integrating newly developed wireless microrobotic technologies with nanomedicine to perform precisely targeted, localized endoluminal techniques. Devices capable of entering the human body through natural orifices or small incisions to deliver drugs, perform diagnostic procedures, and excise and repair tissue will be used. These new procedures will result in less trauma to the patient and faster recovery times, and will enable new therapies that have not yet been conceived. In order to realize this, many new technologies must be developed and synergistically integrated, and medical therapies for which the technology will prove successful must be aggressively pursued.This proposed project will result in the realization of animal trials in which wireless microrobotic devices will be used to investigate a variety of extremely delicate ophthalmic therapies. The therapies to be pursued include the delivery of tissue plasminogen activator (t-PA) to blocked retinal veins, the peeling of epiretinal membranes from the retina, and the development of diagnostic procedures based on mapping oxygen concentration at the vitreous-retina interface. With successful animal trials, a path to human trials and commercialization will follow. Clearly, many systems in the body have the potential to benefit from the endoluminal technologies that this project considers, including the digestive system, the circulatory system, the urinary system, the central nervous system, the respiratory system, the female reproductive system and even the fetus. Microrobotic retinal therapies will greatly illuminate the potential that the in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Therapeutic targeting of the innate immune system in multiple sclerosis'.

assistant: **Concept**

Multiple sclerosis (MS) is neurological disease that is characterized by clinical attacks of paralysis, loss of sensation, loss of vision, and genito-urinary symptoms. MS affects an estimated 500 000 patients in Europe, at a cost to Europe of over 9 billion euro per annum, and is the most frequent cause of neurological disability in young adults. Women are affected approximately twice as often as men.The mechanisms of disease are thought to involve a reaction of the immune system against components of the brain and spinal cord (autoimmune disease). MS is currently treated with drugs that regulate the immune system. Of these, the most frequently used is Interferon-beta (IFNb), a molecule that was initially discovered for its antiviral properties and was subsequently found to be immunomodulating. The technology for the production and purification of recombinant IFNb significantly contributes to the healthcare cost. IFNb can be produced in large amounts by the human immune system, particularly during viral infections.The innate immune system has the capacity to recognise structural components that are shared by viruses, bacteria, and other infectious agents, via cell surface molecules called Toll-like receptors (TLR). In experimental autoimmune encephalomyelitis (EAE), an animal model of MS, we have successfully treated the disease by administering TLR ligands and inducing endogenous IFNb and related molecules. In this translational research project, we are planning to transfer this treatment strategy to MS patients. The overall objective of this project is to make therapeutic use of the innate immune system's ability to produce endogenous interferons, cytokines, and chemokines in MS.TLR agonists will be developed for clinical testing, with the expected benefits to the Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Assessing impacts of tbt on multiple coastal uses'.

assistant: **Objectives**

The project will contribute to the key area A2.2, Reconciling multiple demands on coastal zones, Policy analysis and development to create enabling environment to operationalize (implement) the WSSD decision on aquatic ecosystem restoration. It will focus on the issue of adoption of globally binding instrument against the use of organotin compounds in antifouling measures by IMO and its implications to various other coastal uses. It will target shipping (port activity), cruise tourism, fishing, and aquacult ure. It will place before the international community the issues of concern from the context and perspective of a developing country. It will contribute to strengthen institutional capacity building by helping national governments with policy recommendatio ns and also help build capacity in marine science by appropriate knowledge transfer between European and Asian research personnel. It will sddress the implications of ban to shipping and cruise tourism industry and other coastal uses such as fishing and aq uaculture through scenario building and a cost -benefit analysis of using organotin compounds and alternatives. It will provide information on environmental distribution of TBT in European and Asian coastal environments (including fish and other biota). It will try to formulate safer antifouling measures. It will identify suitable indicators, such as fatty acid biomarkers, of the health of coastal resources and develop quality control tools. It will identify microorganisms for detoxification of TBT. It will develop a biomonitoring system to regulate TBT impacts that exist in coastal environments, and individuate safe fishing areas. Dissemination of the project outputs will be achieved through workshops, newsletters and web-site. In sum, the project will coll ect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'STARs at the EXtreme' in the context of a Horizon 2020 call.

assistant: **Objectives**

The first stars in the Universe are extreme objects. Extreme in their composition: they are made of material having been processed only by the Big Bang nucleosynthesis, and having a content in dark matter likely very different from the one of the present-day stars. Extreme in their properties: one of the most important properties is their mass that might reach values as high as even 100 000 solar masses (supermassive black-hole seeds). Their properties may differ from the today massive star populations also by their likely fast axial spins, the processes of mass loss, their magnetic fields, multiplicity. Extreme in their physics: born in over densities made mainly by dark matter, the physics of candidate dark matter particles may have a significant effect on their evolution and produce what has been called dark or frozen stars, i.e. stars sustained by dark-matter particle annihilation. The aim of STAREX is to determine which observable features can be used to constrain the composition (baryonic and dark matter), the properties (masses, rotation, magnetic field, multiplicity) and the physics of the first stars in the Universe. These observables will be collected by present-day and future facilities as, for instance, the JWST, ELT, adLigo, VIRGO, LISA and are linked to ionising fluxes, nucleosynthesis, radiation of both stellar populations and transient events, and gravitational waves. STAREX will explore new physical processes, build and use new numerical tools, provide observables that will account together for a sophisticated description of the physics of individual stars, single or in binary systems, and for the dynamics of the stars in the first stellar clusters. STAREX is at the crossroad of topics such as stellar physics, nucleosynthesis, hydrodynamics, evolution o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New materials for use in analytical instrumentation' to be submitted under Fourth Framework.

assistant: **Abstract**

The scientific & technical objectives of this research proposal concern the determination of the optimum characteristics of a new ceramic-metallic, composite material free-me" for more effective spectroscopic analytical measurement particularly in the field of Mass Spectroscopy. This research & development work should also provide results to indicate the effectiveness of the new materials in situ. Research is required to determine the optimum level of metal required in the substrate. Research is needed to determine the new materials ("free-me") overall performance Vs the current materials."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ecological effects of protection in Mediterranean marine reserves' to be submitted under Fourth Framework.

assistant: **Abstract**

Marine protected areas are being established around the world at a rapid rate. Some offer protection to pristine natural communities while others attempt to halt further deterioration of sensitive habitats or serve as fishery management tools for long term sustainability of coastal fisheries. The Mediterranean sea supports the biggest population and the highest human pressure of all the EU seas. Because most of the production occurs in the narrow limits of the continental shelf and the human impacts take place there, marine reserves are one of the few available tools to manage this area for sustainable use and for protection of unique ecosystems. At present there are 17 operational marine reserves in the EU Mediterranean littoral where researchers from Spain, France, Italy and Greece have been studying the effects of protection in the ecosystem for more than one decade. Most of the research carried out in Mediterranean reserves has focused on populations of exploited species. However, reserve status can lead to an intricate array of changes to community structure at all trophic levels, starting with direct effects on the populations of exploited species and impacting other populations through ecological interactions between them. These changes may also affect the structure of the habitat in which species live conditioning further their behaviour and distribution. The work carried out so far by the various Mediterranean teams involved in assessing the effects of protection in littoral communities has lacked integration and coordination. In order to move forward in this line of work, it is proposed to first, collate and analyze what has been done and achieved so far by each team individually, and second, to consider appropriate ways to increase the complexity and realism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Intelligent Active Hearing Protection' (IAHP) under Horizon 2020.

assistant: **Objectives**

Wikmanshyttan Safety AB is a Swedish SME started in 1992 with the aim of being a leading producer of above-the-neck personal protection equipment (PPE). The objective of the proposed innovation project as a whole (SME-instrument phase 1 and 2) is to plan, develop, secure and bring our innovative active hearing protection towards commercialization on the global market. In measurable terms we aim to document and reach the following results: • Highest safety on the market – through sensor technology secure that the hearing protection operates at the stipulated attenuation level• Enable Internet-of-Things through sensor technology and thus be able to collect and analyze cloud-based big data e.g. to see if the sound inside and outside the ear-muffs are in a correct interval (high safety) or analyze patterns of movement of staff within a designated area in a specific time period (increased cost efficiency)• Reduced cost for hearing protection through longer durability that in turn is related to condition-based maintenance and spare parts offered • Being able to measure dampness, attenuation, temperature or how the electronics work which will make both the developed product and future products more robust and safe• More environmentally friendly material compared to competitors e.g. take away PVC in sealing rings that are also the spare part to be exchanged• Run an innovation process that takes into account both user involvement and design for manufacturingThe proposed innovation project aims at exploring new market opportunities addressing the EU and global challenge of safety at the workplace. Today there is a lack of well-functioning, highly safe and active hearing protection involving sensor technology that can benefit from the high speed of communication through 4G and 5G.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Assessing the causes and developing measures to prevent the escape of fish from sea-cage aquaculture'.

assistant: **Concept**

The escape of fish from sea-cage aquaculture is perceived as a serious threat to natural biodiversity in Europe's marine waters. Escaped fish may cause undesirable genetic effects in native populations through interbreeding, and ecological effects through predation, competition and the transfer of diseases to wild fish. Technical and operational failures of fish farming technology cause escapes. Cages break down in storms, wear and tear of the netting causes holes, and operational accidents lead to spills of fish. Sea-cage equipment is marketed and used across Europe, thus knowledge relevant to the culture of numerous species in diverse environments is required to produce robust equipment and implement risk adverse operations. The Prevent Escape project will conduct and integrate biological and technological research on a pan-European scale to improve recommendations and guidelines for aquaculture technologies and operational strategies that reduce escape events. Through research focused on sea-cages and their immediate surrounds, we will assess technical and operational causes of escape incidents, assess the extent of escapes of reproductive gametes and fish, determine the inherent behaviours that pre-dispose certain species of fish towards a higher probability of escaping, and document the dispersal of escapees to develop and test recapture strategies. Information from these components of the project will feed into research specifically aimed at benchmarking the performance of equipment under farming conditions and thereby improving operations and equipment production, and advancing national and international standards for the design, construction and use of aquaculture equipment. These key pieces of information, when added to existing knowledge, will allow determinat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cancer Long Survivors Artificial Intelligence Follow Up' to be submitted under Horizon 2020.

assistant: **Abstract**

There were 17 million new cases of cancer diagnosed worldwide in 2018. Survival rates of cancer patients were rather poor until recent decades, when diagnostic techniques have been improved and novel therapeutic options have been developed. It is estimated that more than 50% of adult patients diagnosed with cancer live at least 5 years in the US and Europe. This situation leads to a new challenge: to increase the cancer patients’ post-treatment quality of life and well-being. This proposal aims at identifying cancer survivors from three prevalent types of cancer, including breast, lung and lymphomas. The patient data will be collected from different Spanish hospitals and the selection will be based on ongoing health and supportive care needs of the particular patient types. We will determine the personalised factors that predict poor health status after specific oncological treatments. For this aim, Big Data and Artificial Intelligence techniques will be used to integrate all available patient´s information with publicly available relevant biomedical databases as well as information from wearable devices used after the treatment. To predict patient-specific risk of developing secondary effects and toxicities of their cancer treatments, we will build novel models based on statistical relational learning and explainable AI techniques on top of the integrated knowledge graphs. The models will utilise background knowledge of the associated cancer biology and thus will help clinicians to make evidence-based post-treatment decisions in a way that is not possible at all with any existing approach. In summary, CLARIFY proposes to integrate and analyse large volumes of heterogenous multivariate data to facilitate early discovery of risk factors that may deteriorate a patient con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards an instrument-free future of molecular diagnostics at the point-of-care' to be submitted under Horizon 2020.

assistant: **Abstract**

Molecular diagnostics is still primarily a lab-based method. Emerging technologies for application at the point of care (POC) or need, i.e., where a patient or a sample is, have started gaining a big part of the molecular diagnostics market. Interestingly, available methods are divided in two groups: sophisticated instruments for ultra-sensitive temperature-regulated enzymatic amplification of nucleic acids and extremely simple paper-based immuno-diagnostic kits. Complexity, the main disadvantage of the former, results in their poor translation to several applications at the POC. Simplicity, often accompanied by failures, of the latter is the reason for their slow adoption even in resource limited areas. Our vision is an instrument-free approach that combines the advantages of both groups, i.e., a method that does not use heaters or modules that require electricity, infrastructure and maintenance, but, still, takes advantage of enzymatically-amplified nucleic acids detection. To achieve the above, novel diagnostic tools for genetic amplification based on ligases, polymerases and restriction enzymes operating at ambient temperature will be developed, combined with quantitative smartphone colorimetric/UV detection. The global applicability of the new approach will be demonstrated during infectious disease (Influenza and HIV) testing in human samples (blood and swabs) and plant pathogens (Xylella fastidiosa) in plant-tissues. In all cases, we aim for a time-to-result of less than 60 min, demonstrated sensitivities down to the clinically/field relevant values and a final cost in the order of $1 per assay. Combination of Free@POC concept with newly developed predictive models will expand its utility to monitoring disease outbreaks and their spreading. This new generation of