RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Synthesis and nanostructuration of a Pi-conjugated polymer for dye sensitized solar cells' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

π-Conjugated semiconducting organic polymers have gained a widespread interest for their potential application in thefabrication of organic electronic devices. Efficiency of these devices largely depends on the ability of the polymeric film totransport charge; thus attempts are being made to enhance the charge mobility by improving crystallization, aggregation andorientation of the material during the pre-processing. Dip coating, spin coating, doctor blading and thermal annealingtechniques are being used for the development of oriented microstructures, however, these techniques are not practicableon a large scale. However, microfluidics is an emerging multidisciplinary field with practical applications in lab-on-a-chiptechnology. It deals with the precise control, behaviour and manipulation of fluids. It has widely been used for the controllednucleation and crystallization of small conjugated materials.The aim of this project is to synthesize new soluble conjugated organic polymers by simple solution polycondensationmethod. The monomers and the resulting polymeric material will be characterized by using the standard techniques. Newmicrochannel system will be designed and fabricated by using polymer, glass or thermoplastics. The polymer solutions willbe pre-processed (under optimized conditions like temperature, flow rate or magnetic field) by micro-fluid technique forprecise manipulation of crystallization, aggregation and orientation in the solution form. Effect of the variable flow rate,solvent systems and temperatures will be studied. The processed solution will be then spin coated to fabricate prototype dyesensitized solar cell. Atomic force Microscopy, Grazing-incidence wide-angle X-ray scattering, UV visible spectroscopy willused to investigate the aggregation and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Imaging Micro-Calorimeter' under Fourth Framework.

assistant: **Concept**

The Scientific and Technical objectives of this project proposal conern the application of adances in infra-red detection and infra-red transmitting materials together with state of the aret imaging electronics and cryo-cooling to provide a novel system for monitoring the metabolic status of cells. (Either individual aggregates of cells or larger populations of eukaryotic cells growing oncigously in a cell sheet on a specially prepared tissue culture surface. Research is required to establish the optimal I.R. technology to employ and to devise a versatile, compact, economical, environmentally friendly and highly efficient cryo-cooler or ultra-cryo-cooler.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Involvement of RNA-binding Proteins in the plant responses to drought and salinity' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The effect of increasing atmospheric CO2 concentrations and global warming on the distribution and function of plants on earth is unpredictable. The stornata control both the influx of CÜ2 for photosynthetic carbon fixation and water loss from plants through transpiration.Thus, stomatal movement is one of the major processes that will be affected by the climate changes. In addition to contributing to the basic knowledge, understanding of the signal transduction mechanisms, which control stomatal movements, could have both ecological and practical agriculture applications.The phytohormone abscisic acid (ABA) plays a central role in the regulation of the stornata function in response to drought-salt stresses. Under such stresses, ABA is synthesised and induces stomatal closing. The host laboratory has recently isolated a new Arabidopsis gene, ABH1 that controls signal transduction by ABA (Hugouvieux et al., 2001, Cell).The first objective of this project is to functionally characterize the RNA binding protein ABH1 in order to determine how RNA processing modulates ABA signal transduction. Our hypothesis is that ABH1 binds to specific transcripts by direct interaction or by interacting with other regulatory proteins.We will isolate and identify the specific transcripts to which ABH1 binds as well as the putative regulatory proteins interacting with it. Our studies will involve in vivo and in vitro approaches using novel proteomic, genomic and time resolved imaging tools. In the home institution we have undertaken a systematic search for sugar beet halo tolerant genes that could be involved in the salt tolerance response of plants.Several genes encoding RNA binding proteins were isolated, but the mechanism underlying this salt tolerance is unknown. During the second and thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pan-European Research infrastructure on High Performance Computing for 21st century Science' under Seventh Framework.

assistant: **Concept**

The main objective of HPC-Europa2 is to continue the provision of a high quality service for transnational access to the advanced HPC systems available in Europe. This activity has been available on an ongoing basis as a highly-rated and trusted service for almost two decades.  The HPC-Europa2 partnership includes as Transnational Access centres CINECA (Italy), BSC (Spain), EPCC (UK), HLRS (Germany), SARA (The Netherlands), CINES ( France) and CSC (Finland).  The project is organised around its core activity, the Transnational Access (TA) HPC service provision. Over the four year life span of the action, the TA will provide HPC services, specialist support, scientific tutoring and opportunities for collaboration to more than 1,000 European researchers.  This very large community of users will be provided with more than 22 million of CPU hours of computing time.  A number of Networking activities are implemented around the core business of the project; to interact with the HPC ecosystem in Europe, mainly represented by DEISA and PRACE; to coordinate the transnational access activities carried on by the different partners; and to coordinate the activities related to user support, consultancy support and the diffusion and dissemination of the HPC culture.  Three Joint Research Activities are also integrated into the project; to provide innovative solutions for parallel computing on massive parallel architectures; to develop tools for scientific data services offering ease of access, analysis and visualisation of complex distributed data sets; and to create a virtual cluster environment which enables researchers to prepare and familiarise themselves with the HPC environment in advance of their visit, thus increasing the effectiveness and productivity of transnational access
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targeting Cancer Cell Invasion and Metastasis by Inhibition of the Serine Kinase MRCKa' (2014-2020).

assistant: **Concept**

Metastasis is the primary reason for cancer death, and metastatic spread drastically worsens the prognosis of cancer patients. As cell migration is the biological process underlying the spread of cancer cells, better understanding of it is crucial for the development of novel therapies in reducing cancer invasion and increasing patient survival. Yet, little has been accomplished in terms of the development of anti-metastasis drugs. MRCKa is an effector of Rho GTPase, and molecular studies have suggested it to play important roles in cancer cell migration. However, the potential of targeting MRCKa in metastasis has not been validated due to the lack of in vivo evidence and specific inhibitors. Hence, this project aims to validate MRCKa as an important drug target for the treatment of metastatic cancers. The first objective aims to investigate the role of MRCKa in cancer development and metastasis by utilizing a breast cancer model on MRCKa knockout mice. Secondly, MRCKa was reported to influence cell migration by multiple mechanisms, including promoting cell contraction, reducing actin turnover, and filopodia formation. To better define the molecular signaling of MRCKa during metastasis, the importance of these effector pathways in cancer cell migration will be investigated. Specifically, MRCKa knockout breast cancer cell line derivatives will first be generated, and their ability to migrate and invade studied in 3D spheroid cultures. The importance of the effector pathways will be investigated through targeted gene inactivation and inhibitors. Finally,MRCKa has two closely related family members, MRCKb and MRCKg, and also shares functional similarities with ROCK1 and ROCK2. With the aim to obtain a more efficient inhibition of cancer cell migration, the third objective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Cultural Heritage Applications Network Part (Refers to CULTIVATE-EU Proposal No. IST-1999-1113)'.

assistant: **Objectives**

CULTIVATE CEE will extend the European Cultural Heritage Network, already established in the EU, EFTA countries and Israel, to the ten Central and Eastern European Associated States (Bulgaria, Romania, Slovenia, Slovakia, Poland, Czech Republic, Lithuania, Latvia and Estonia). An accompanying measure to Key Action III - Multimedia Content and Tools of the IST Programme, CULTIVATE CEE will aim to set up nodes with representatives from all the relevant memory institutions and organisations (in particular from archives, libraries and museums) in each of these countries in order to raise awareness and promote the cultural heritage area of IST. CULTIVATE CEE will extend the European Cultural Heritage Network, already established in the EU, EFTA countries and Israel, to the ten Central and Eastern European Associated States (Bulgaria, Romania, Slovenia, Slovakia, Poland, Czech Republic, Lithuania, Latvia and Estonia). An accompanying measure to Key Action III - Multimedia Content and Tools of the IST Programme, CULTIVATE CEE will aim to set up nodes with representatives from all the relevant memory institutions and organisations (in particular from archives, libraries and museums) in each of these countries in order to raise awareness and promote the cultural heritage area of IST.OBJECTIVESThrough a variety of means (web pages, interactive web magazine, email information service, etc.) CULTIVATE CEE aims to raise awareness of the IST Programme for the development and use of cultural heritage applications throughout the CEE Associated States, to strengthen involvement and meaningful participation in the programme and to create a pan-European network of cultural heritage nodes.DESCRIPTION OF WORKCULTIVATE CEE will start its work by the partners establishing cultural heritage no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The process of professionalization in European science, 1789-1850' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The modern science was born in Europe at the beginning of the seventeenth century, but it was not until the middle of the nineteenth century that the scientific research became “professionalized” as we know it today. Such a process of “professionalization” was a milestone in the development of the European intellectual heritage and made Europe the world leader in the production of knowledge. Its comprehension might offer new hints and suggestions for drawing the future of Europe as leading the growth of knowledge. The project aims to investigate such a complex process taking into account both the historical context and the role of new episthemic, methodological, and axiological ideas developed by scientists around 1800. The collaboration with the CNRS Institut des Text et Manuscrits Modernes (ITEM) in Paris is crucial for the project and stimulating the growth of complementary competences of the Researcher. The ITEM has developed methodologies in order to follow the genesis of concepts from textual sources. Recently the ITEM has applied such methodologies and tools to the history of science, and this project can strengthen and enlarge such an application. Besides, the ITEM has recently elaborated information technology tools which are devoted to the electronic treatment and presentation of the textual sources. Such tools will contribute to reinforce impact and visibility of the project’s results. Pursuing the project in such an innovative way will have a significant impact on both our understanding of the process of professionalization in science and the scientific career of the Researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Large scale campaigns to demonstrate how TSO-DSO shall act in a coordinated manner to procure grid services in the most reliable and efficient way' to be submitted under Horizon 2020.

assistant: **Abstract**

The CoordiNet Innovation Action proposal aims to demonstrate how DSOs and TSOs shall act in a coordinated manner to procure grid services in the most reliable and efficient way through the implementation of three large scale “TSO-DSO-Consumer” demonstrations, in cooperation with market participants (and end users). The consortium will define or adapt, demonstrate and promote future standardized grid services and related market platforms to enable a seamless pan-European electricity market.The CoordiNet consortium under the coordination of ENDESA is composed of 23 beneficiaries and 10 linked third parties from 10 different European countries. It is supported by an Advisory Board and a Stakeholders’ Forum to liaise with on-going projects in Europe and beyond. Three complete value chains of TSO-DSO-market participants constitute the backbone of the project in three demonstration macro-areas (Spain, Sweden, Greece) with ten demonstration pilots (four in Spain, four in Sweden and two in Greece) representing various boundary grid, climatic, load and generation conditions. Next to the demonstration campaigns, promising game-changer enabling technologies, such as IoT, Artificial Intelligence, Big data services, P2P energy trading platforms, Blockchain, Distributed ledger Technologies will be tested to explore alternative means to facilitate energy prosumers participation of small-scale energy consumers into the markets.Over the CoordiNet demonstration areas, the extent of demonstrations provides high level of added value to extrapolate features of TSO-DSO-market collaboration on a European wide-area through the set of standardized products that will be defined and field-tested and the building blocks for a future European platform that will contribute to opening new revenue str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Generation of human steroid-producing organoids: a new approach to treat adrenal insufficiency' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The adrenal cortex is essential for life; it is the primary site of steroid synthesis, producing glucocorticoids, which affect carbohydrate metabolism and mediate the mammalian stress response and mineralocorticoids, which control blood volume and salt homeostasis. Adrenal insufficiency (AI), which can be life threatening, is cause by a number of adrenal disorders, and lifelong management of these patients with exogenous steroids can be challenging. No drug suitably mimics the diurnal pattern of cortisol noted in healthy individuals, and objective variables to measure hormonal replacement therapy quality are lacking. The ability to generate steroid-producing cells from pluripotent stem cells through cell reprogramming, a process where a specialized cell type is induced to transform into a different cell, offers a new paradigm for functional studies, modelling human disease and drug testing and eventually can be used as a cell source for cellular therapies for patients suffering from adrenal conditions. This proposal aims to develop methodologies to generate adrenal-like organoids from human embryonic stem cells (hESCs), which have not been generated so far, without requiring overexpression of exogenous transcription factors and test them in in vivo models of adrenal insufficiency. Because small molecules provide several distinct advantages in controlling protein functions (e.g., temporally controllable, reversible, tunable and tractable) I will utilize them for a faster, more efficient, and directed cellular reprogramming. CRISPR-Cas9 genome engineered steroid-producing organoids harbouring common mutations found in congenital adrenal hyperplasia (CAH), the most common type of AI, will be generated and used as a disease modelling platform to study CAH. This proposal aim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart Morphing and  Sensing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Smart Morphing & Sensing is a multidisciplinary project associating novel electroactive actuators and sensors to increase aerodynamic efficiency and attenuate vibrations and noise. This is achieved via aerostructural morphing exploiting the real-time information from the distributed actuation and sensing systems. This goal is achieved by actuating the smart-materials to deform the structure according to optimum shape design by means of Flight Control Commands. The novel “intelligent material” technology is a hybrid association of small piezo-actuators distributed along the control surface, of Shape Memory Alloys and of Electroactive Polymers, disposed under the ‘skin’ of the active structure. This novel hybrid design allows associating fast time response and vibrational actuation with simultaneous high deformation ability. The ability in capturing energy from the already existing vibrations and redistributing it in the actuation will be used to partially supply the system and therefore ensure an economic and realistic morphing. This is beyond the cutting edge of the state of the art in morphing concepts. The use of novel distributed pressure sensors based on fiber Bragg grating provides real-time information on the actuation performance and the flight situation enabling an efficient in-situ optimization using a dedicated controller interfacing the actuators with the fiber based sensors. Aerodynamic and structural experiments are included to demonstrate the abilities of the new integrated smart sensing and morphing design via real-time actuation. High-fidelity aeroelastic computations are used to optimize the actuators location and function. The experiments will study the increase of the aerodynamic efficiency in cruise, take-off and landing by controlling the turbulence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Communicate Heal-th: A Virtual Reality training tool for optimizing expectancy effects in patient-provider interaction' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

As shown in the EXPECT-HEALTH project (617700), positive treatment expectations lead to improved health outcomes, while negative expectations have the opposite effect. To make use of this phenomenon in clinical practice, interventions have been developed to improve treatment expectations in patients, but these thus far only target the patient. A novel application would be to instead train healthcare professionals to optimize the expectations of their patients. This allows a much bigger audience to be reached with less investment. To make the training as efficient and effective as possible, state-of-the-art technological means must be used. We therefore propose an innovative virtual reality-based training tool for healthcare professionals, that will teach them to optimize expectations in their patients. In this project, the virtual training tool will be developed and brought to the pre-demonstration phase by a team of experts in expectancy effects on health and eHealth intervention development.


**Keywords:** patient-provider interaction, placebo effects, nocebo effects, eHealth, virtual reality, virtual patients, intervention development, expectancy