RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of electrodes based on copper chalcogenide nanocrystals for photoelectrochemical energy conversion' (COCHALPEC).

assistant: **Innovation**

Solar energy is renewable and abundant enough to meet the growing energy demand, but its variability limits the application. Direct storage in the form of a clean fuel, like hydrogen, would solve this problem.Photoelectrochemical (PEC) cells employ solar energy to split water molecules producing H2 and O2. Thin films of Cu2ZnSnS4 (CZTS) and ZnCuInS2 (ZCIS) have shown remarkable efficiencies in photovoltaics (PV) and preliminary promising results in PEC cells, but costly fabrication. Currently, much attention is being paid to the synthesis of nanocrystals (NCs) of these materials because of their low cost preparation and tunable optical and electrical properties just by controlling the nanometer dimensions of NCs and the composition of the particles, giving more versatility to meet the energetic requirements for water splitting. These new materials in the forefront of PV remain unexplored in water splitting PEC cells to date.In this project, we propose the fabrication of photoelectrodes based on CZTS and ZCIS NCs to perform the water splitting. First, the control over the size, shape and composition of these NCs will be demonstrated using inexpensive solution-based techniques. Next, two photoelectrode configurations (viz. sensitized metal oxide and 3D-arrays of NCs) will be pursued applying state of the art overlayers to improve the charge separation and the catalytic activity at the interface with water. Finally a PEC device will be assembled that demonstrates a 5% overall solar to hydrogen conversion efficiency. In this research we propose a bottom-up approach whereby the comprehensive analysis of the interfacial charge transfer will both contribute to the basic science of solar energy conversion systems and optimize the performance of very promising materials for dire
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cell biology of inflammasome activation in macrophages infected with Francisella' (INFLAFRAN) under Seventh Framework.

assistant: **Objectives**

The inflammasome is an innate immune signalling pathway that is key to fight infections. Inflammasome activation leads to caspase-1 activation, secretion of pro-inflammatory cytokines and host cell death. Inflammation and cell death can be deleterious for the host and the inflammasome has been involved in numerous inflammatory syndromes. Despite its key importance in the immune responses to infections and in diseases, the cell biology of inflammasome activation remains unclear. Particularly, the spatiotemporal localization of the different players (the receptor, the adaptor ASC and the effector caspase-1) remains to be studied. Furthermore, the interaction of the inflammasome pathway with other innate immune pathways such as the autophagy pathway or with bacterial virulence factors is still unclear. Francisella tularensis is a highly infectious bacterium that causes tularemia. Its pathogenicity is linked to its ability to replicate within the cytosol of macrophages. The outcome of the infection depends on the balance between bacterial virulence factors and host immune responses, which include the inflammasome and the autophagy pathways. Francisella infection is detected by the macrophages through the Aim2 inflammasome. In this project, we propose to set up an inflammasome reporter system to monitor in real time and in single cells, the dynamic of Aim2, ASC and caspase-1. This will allow us to dissect the cell biology of inflammasome activation during Francisella infection and particularly to address the following points:• What are the spatiotemporal dynamics of the different players?• What is the connection between the inflammasome and the autophagy pathways?• What are the molecular mechanisms of Francisella virulence factors that modulate inflammasome activation?We bel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Visible-light-activated transmembrane transport by photosensitized isomerization of stiff-stilbene based anion receptors' (SENSiTRANS) under Horizon Europe.

assistant: **Objectives**

Stimuli-responsive transmembrane anion transport proteins are essential for cellular life due to their implication in important biological functions. Supramolecular systems with analogous properties have been developed, however, most of them rely on the use of damaging UV light. SENSiTRANS is an ambitious and multidisciplinary project aimed at activation of anion transporters using visible light by means of a sensitization strategy. The project focuses on the employment of photosensitizers able to trigger isomerization of stiff-stilbene based receptors in the lipid bilayer, allowing activation of passive transmembrane transport. In addition, insertion of the photosensitizer in a vectorial manner into the lipid bilayer will be explored towards light-driven active transport. The project will result in i) the development of a new strategy to control transmembrane transport with transformative impact in the field of molecular photoswitches and anion receptor chemistry, ii) preparation and growth of the fellow towards a fully independent academic career (the new scientific research skills, complementary soft skills and scientific connections she will acquire will provide her with the necessary competencies to access an academic position at an European institution), and iii) benefit from her multidisciplinary scientific background and her scientific network by the hosting group.


**Keywords:** Transmembrane transport, molecular switches, anion binding, photochromism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Advanced policies and market support measures for mobilizing solar district heating investments in European target regions and countries'.

assistant: **Innovation**

SDHp2m stands for ‘Solar District Heating (SDH)’ and actions from ‘Policy to Market’. The project addresses market uptake challenges for a wider use of district heating and cooling systems (DHC) with high shares of RES, specifically the action focuses on the use of large-scale solar thermal plants combined with other RES in DHC systems.The key approach of the project is to develop, improve and implement in 9 participating EU regions advanced policies and support measures for SDH. In 3 focus regions Thuringia (DE), Styria (AT) and Rhone-Alpes (FR) the regulating regional authorities are participating as project partners to ensure a strong implementation capacity within the project. In 6 follower regions from BG, DE, IT, PL, SE the regulating authorities are engaged through letters of commitment. The project activities aim at a direct mobilization of investments in SDH and hence a significant market rollout.The project work program in the participating regions follows a process including 1) strategy and action planning based on a survey, best practices and stakeholder consultation 2) an implementation phase starting at an early project stage and 3) efficient dissemination of the project results at national and international level.Adressed market uptake challenges are: Improved RES DHC policy, better access to plant financing and business models, sustained public acceptance and bridging the gap between policy and market through market support and capacity building. Denmark and Sweden reached already today a high share of RES in DHC and shall be used as a role model for this project.The direct expected outcome and impact of SDHp2m is estimated to an installed or planned new RES DHC capacity and new SDH capacity directly triggered by the project until project end correspondi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intracorporeal Narratives: Reading Internal Biology in Women’s Literature, 1880s-1930s', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

My project examines British and American women’s fiction of the late nineteenth and early twentieth centuries for its depictions of internal anatomy: organs and systems, circulatory, nervous, reproductive, and digestive. This study will make a distinctive contribution to the field of medical humanities: the development of an analytical process of body-centred reading, and new analysis of how women’s writing communicates bodily experiences and depicts the ‘intracorporeal’, narrative journeys through concealed and invisible organs. The project questions: how do visualisations of the body's insides and internal workings change through time? Does literature reflect medical developments and discoveries, for example echoing the shift from the nervous to the hormonal body? How are metaphors employed to aid us in visualising these systems and parts: the nervous system as a network of vibrating strings, hormones as postal packages or chemical messages, the sperm and egg as static and kinetic, the biological clock? My work surveys the persistent desire to find a physiological rationale, to map pain internally, even when that pain has an emotional or psychological source. I also explore how changing conceptualisations of the body interact with gendered notions of pathology and disorder. Comparing fictional texts to medical writing and advertising of the same era, I will track the development of and interaction between the medical understanding of the internal body, communication in the public realm, and exploration in literature.


**Keywords:** Medical Humanities,  Literature and Medicine,  Bodies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dereverberation and Reverberation of Audio, Music, and Speech""' (DREAMS).

assistant: **Innovation**

The DREAMS Initial Training Network will investigate the problem of modeling, controlling, removing, and synthesizing acoustic reverberation with the aim of enhancing the quality and intelligibility of audio, music, and speech signals. The proposed research and training program builds upon four disciplines that are equally important in understanding and tackling the (de-)reverberation problem: room acoustics, signal processing, psychoacoustics, and speech and audio processing. The strong commitment of the private sector in the proposed ITN consortium, consisting of 4 academic and 8 industrial partners, illustrates the timeliness and importance of the (de-)reverberation problem in a wide variety of applications. However, carrying application-driven solutions is not the only objective of the DREAMS research program. Indeed, the aim is also to take a significant step forward and make fundamental scientific contributions in each of the four disciplines mentioned earlier. To this end, the envisaged ITN will host 12 early stage researchers and 4 experienced researchers, each performing an individual research project around one of four themes that reflect the most challenging open problems in the area of (de-)reverberation. The DREAMS ITN will be implemented such as to maximize the international and intersectoral experience of the research fellows, by defining relevant secondments in academia and industry, both in the host country and abroad. Moreover, experienced researchers will be expected to take on a supervisory role in coordinating one of the four research themes, with the aim of developing solid skills in leadership and research management. Finally, a training program of extremely high quality is proposed, with local as well as network-wide training, which relies on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SEwer inventory system to safeGUard waste water infrastructures'.

assistant: **Innovation**

Waste water networks have been an organic growing system in a 200 year process of pipes, leads, wells, etc. As there was never a standardized inventory system, governments have no or only partial information of their underground (waste) water infrastructure. Without this information crisis management plans for health threats, floods, collapses or calamities are hard to execute. Plans for water management (scarcity of water resources), next generation emergency services (fire brigades), rainwater drainage challenges (enlarging urban environments) or strategic use of sensor systems to detect gas, drugs or explosives are essential and complex tasks. As Europe is urging to solve the issues mentioned above (Groundwater directive, Urban Drainage, Water Framework directive), local governments are looking into this matter. Compiling all the data concerning the exact location and structural status of complete sewerage facilities is expensive and very time consuming. Additionally, all inventory jobs are done manually, error prone & inaccurate, dangerous and operator bound. SEGU offers a solution to the European challenge by allowing for accurate digital 3D data that can be obtained 4 times faster, less expensive and safer. The aim of the SEGU (SEwer inventory system to safeGUard waste water infrastructures) project is to ensure market introduction of a Waste Water Infrastructure Data Service within EU28 as well as proper management of waste water infrastructure. This feasibility study will focus on partner search, study of market mechanisms, local legislation / restrictions, and will result in an extensive business plan towards an EU strategy. Specifically, phase I entails: - Market mechanisms analysis - Business models assessment (services of big data) - (Local) regulations & le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Licenciement economique comme facteur d'exclusion sociale' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

I. OBJECTIVES. Our research is directed at one of the major causes of social exclusion, the loss of employment, in particular through redundancy. Redundancy represents, in fact, a major risk leading to social marginalisation for two main reasons: because, Its first victims are those who can be considered as fragile. Furthermore, in Europe in general redundancy is one of the main causes of loss of employment and it is well known that it leads above all to the phenomenon of longterm unemployment. This research will deal with 4 questions: 1) to what extent do prevailing redundancy laws and corporate practices and procedures lead to the risk of exclusion? 2) once a redundancy decision has been taken what responsabilities are incumbent on the firm? 3) what are the mechanisms and measures provided by the State to avoid the process of social marginalisation? 4) what interaction exists between the responsabilities of the firm and the role of the public authorities in this area? The objective of our study is thus to highlight the similarities and the differences in the selection process leading to redundancy in 4 different EC Members (Germany, Spain, France and Italy) and to assess the effect of the different public or private mechanisms designed to combat the social exclusion of the employees concerned. The ultimate objective is to contribute to the debate on the implementation of current EU Directives on redundancy and possible future modifications. II- NATURE OF THE WORK Scope: all forms of redundancy, wether they be collective or individual, with or without a social plan or other such procedures. This work requires a contribution from legal specialists (legal and institutional structures) management specialists (human resources management inside and outside the firm). The ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'NANODESIGNED CHIRAL HYBRID ORGANIC-INORGANIC MATERIALS AS CATALYSTS FOR GREEN REGIO AND ENANTIOSELECTIVE OXIDATION REACTIONS' under Sixth Framework.

assistant: **Concept**

A major challenge in heterogeneous catalytic processes is the development of heterogeneous catalysts for asymmetric synthesis of fine chemicals. By following a new approach, this project intends to design and construct hybrid organic-inorganic materials consisting of a chiral pore system and four-coordinate transition metal ions as catalytic sites. The use of chiral bis(trialkoxysilanes) and supra-molecular assemblies of surfactants as templates will result in catalysts designed at the nano-scale level able to carry out the enantio-selective oxidation of different substrates (i.e., alkanes, alkenes and sulfides to give enantiopure alcohols, epoxides and sulfoxides, respectively). Since both the catalysts and oxidants (i.e., molecular oxygen, hydrogen peroxide) are environmentally friendly, these processes will represent interesting examples of the so-called green chemistry. The securing of the scientific objectives of this proposal would suppose a major breakthrough in the modern heterogeneous catalysis.The background, previous experience and achievements of the applicant in this field will be crucial for attaining these goals by following a work plan which distributes the objectives by applying the research methodology and assures a constant work through the whole duration of the project. In addition, this fellowship would be able to contribute greatly to the development of the applicants potential as an independent world-class researcher through the acquisition of both scientific training and complementary skills, thus contributing not only to scientific but also lifelong personal achievements, according to the objectives of the Marie Curie Incoming International Fellowships.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microglia-synapse molecular interactions in neurodegenerative disorders' (MicroSyn-MIND).

assistant: **Innovation**

Microglia are immune cells that monitor our brain and degrade unhealthy neurons and excess synapses. In Alzheimer’s disease (AD) however, microglia excessively destroy synapses, marking them as enticing treatment targets. AD patients accumulate cortical Amyloid-beta (Aβ) plaques and neurofibrillary tau tangles, whilst losing neurons and synapses, and consequently: memory and cognition. Microglia are the brain’s immune cells, mediate neuroinflammation, continuously monitor their surrounding cells, and prune (eliminate) excess synapses during development. Interestingly, various AD risk genes are highly expressed in- or linked to- microglia, and while “activated” microglia can clear Aβ, they also degrade neurons and synapses. Our knowledge on microglia function mainly stems from rodent studies, which show microglia can target synapses via complement molecules or fractalkine, but we do not know exactly which proteins mediate this contact, how this translates to humans, and how this is affected in AD.I hypothesize that microglia use different cell surface proteins to interact with synapses in AD, compared to a healthy brain. By combining several cutting-edge technologies, I can now test this hypothesis in living, human microglia. I will transplant human iPSC-derived microglial progenitors into the cortex of healthy- and APPNLGF mice, to ensure the microglia develop a transcriptional- and morphological state like human in vivo microglia (expertise of the Mancuso lab). Using TurboID proximity labeling and quantitative high-resolution mass spectrometry, I will tag-, extract-, and identify the proteins at the microglia-synapse interaction site and determine how they differ from the AD mouse model (expertise of the De Wit lab). Given that abnormal microglial function is linked to