RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ice ages, Sea level, and Magmatism: Coupled oscillations' (ISMAGiC).

assistant: **Innovation**

There is widespread recognition of the connectivity of different components of the Earth system, but many of these connections have not been studied. This is certainly true of connections between climate and the solid Earth. A thorough understanding of the climatic variations recorded in the geologic record cannot be obtained by studying climate in isolation from the solid Earth, and a complete understanding of the volcanic record requires consideration of the effects of climate variation.  This is a proposal to investigate the coupling between climate and the solid Earth, and hence to better understand climate history and its impact on volcanism.  The proposed work will use computational models of two-phase magma/mantle dynamics and petrology to explore links between glacial cycles and mid-ocean ridge volcanism.  Glacial cycles redistribute water between the oceans and continents, changing sea level and hence varying the load on mid-ocean ridges.  Melting beneath ridges responds to pressure changes, and should produce observable variation in crustal thickness and concentration of incompatible elements. Carbon dioxide is one such incompatible element, and pressure-induced variations in out-gassing rate from the mid-ocean ridge system to the climate system may provide the negative feedback that gives rise to glacial oscillations.  The plausibility of this hypothesis depends on details of the response functions of the coupled systems.  The proposed research group will develop a set of independent but synergistic projects that employ computational simulation to assess these responses, make testable geochemical and geophysical predictions, and validate models against observational data. This investigation has the potential to transform our understanding of mid-ocean ridge v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Role of DNA methylation reprogramming in germline stress response'.

assistant: **Innovation**

Cytosine methylation is an ancient epigenetic modification that carries essential regulatory functions in eukaryotic genomes. This modification is reprogramed in both male and female germlines of mammals, regulating essential germline functions. My host lab discovered that DNA methylation reprogramming also occurs in male germlines of flowering plants, such as Arabidopsis, rice and maize. This reprogramming is catalyzed by the RNA-directed DNA methylation pathway (RdDM), which methylates hundreds of genes specifically in the male germline. In Arabidopsis, this germline-specific methylation (GSM) regulates male meiosis by controlling gene transcription and splicing. It is unknown if methylation reprogramming also occurs in plant female germlines. Furthermore, our preliminary data suggest that GSM is modulated by ambient temperature. It is mysterious if and how environmental modulation of methylation reprogramming contributes to stress tolerance in plant germlines. I propose to answer these questions in Arabidopsis using a combination of single-cell genomics, epigenetics, genetics and developmental biology approaches. My preliminary work detected GSM in the egg companion cell and gynoecium (female organ), whose development was reported to be affected by RdDM mutations. Data also suggest that heat-induced modulation of GSM activates a heat shock gene in male meiocytes. Thus, I hypothesize that methylation reprogramming occurs and plays essential regulatory roles in the female germline, and beyond; an important function of such reprogramming is to mediate germline response to environmental stresses such as heat. Here, I will test this hypothesis and elucidate the scope, mechanism and environmental adaptation function of germline reprogramming. My discoveries will elucidate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Low-temperature heat valorisation towards electricity production' under Seventh Framework.

assistant: **Concept**

Low-temperature process waste heat is primarily valorized to provide heat to other applications and, more rarely, to provide cooling or to produce electricity, which is often perceived to be less attractive.  However, generating electricity does represent a rational alternative, since it may circumvent drawbacks linked to demand seasonality and location.  The LOVE project aims at developing innovative technological solutions to generate electricity from low-temperature (< 120°C) waste heat sources identified within various industrial processes, in general, and specifically in the cement industry which is among the more energy-intensive applications worldwide. Innovative thermodynamic cycles will be investigated while existing ones will be optimized. Advanced solutions for heat exchangers operating in hostile environments will be developed along with a particularly efficient turbine solution.  A systemic approach will be implemented using a computer-aided tool providing for overall system optimization.  Two small and mobile demonstration units will be built and tested in a partner laboratory and again installed and tested at two partner industrial sites. Further applications of the proposed technological solutions to other energy-hungry industrial sectors and to the waste heat recovery on CHP plants will also be evaluated. This project will result in important advances in applied cycle thermodynamics, as well as in industrial system modeling and optimization, thus allowing for significant technological developments which will be applied to the cement production sector. The constitution of the consortium partners ensures an excellent cross-fertilization towards the realization of the project objectives.  The consortium combines the strengths of leading actors in the indus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum Interactions in Photon-Induced Nearfield Electron Microscopy' (QUIN-PINEM).

assistant: **Concept**

Breakthroughs in electron microscopy over the past 15 years have introduced femtosecond laser-driven electron microscopes that probe matter and even hybrid light-matter polaritons with ultrafast time resolution. However, such systems still mostly extract classical properties of light and matter. This project will pursue the next frontier – extract quantum properties of light and matter, such as correlations and entanglement. We will develop a new concept of laser-driven electron interferometry for the goal of creating and measuring quantum correlations in the ultrafast regime.Over the past 4 years, my group has shown how free electrons can interact coherently with light in photonic cavities and even get imprinted by the quantum photon statistics of light. Leveraging such interactions enabled us and other groups to develop theories and experiments for controlling the wave nature of individual electrons, creating coherently modulated electron wavepackets.Here we will harness such coherent electron modulation to develop new microscopy modalities that can reveal important quantum properties of light, matter, and their interactions: We are going to make the first observation of quantum nonlinear optical dynamics of polaritons in 2D materials, to measure the quantum state dynamics in superradiant quantum dot ensembles, and to capture the spatiotemporal dynamics of correlated matter, such as the creation and annihilation of vortices in superconductors.Toward this goal, we will develop a unique ultrafast free-electron interferometer operating at cryogenic temperatures. Exploiting the quantum electron-photon interaction in this system can create unprecedented many-electron entangled states that break classical limits in electron microscopy. Specially designed photonic cavities w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Pathogen and Graphene' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Complications related to infectious diseases have significantly reduced, particularly in the developed countries, due to the availability and use of broad-range antibiotics and wide variety of antimicrobial agents. Excessive use of antibiotics and antimicrobial agents increased significantly the number of multi-drug resistant (MDR) bacteria. This has resulted in a serious threat to public health. The inexorable rise in the incidence of antibiotic resistance in bacterial pathogens, coupled with the low rate of emergence of new clinically useful antibiotics, has refocused attention on finding alternatives to overcome antimicrobial resistance. Novel strategies aiming to reduce the amount of antibiotics, but able to prevent and treat animal and human infections should be investigated, evidenced and approved. Among the various approaches, the use of graphene and its derivatives is currently considered a highly promising strategy to overcome microbial drug resistance.In line with this interest in graphene by the European Commission through the graphene ‘flagship’ initiatives, we respond in this consortium by exploring the utility of novel graphene based nanocomposites for the management and better understanding of microbial infections. The anti-microbical potential of the novel graphene based nanomaterials, the possibility of using such structures for the development of non-invase therapies together with the understanding of the mechanism of action will be the main focal points of the proposed project entitled “PANG”, relating to Pathogen and Graphene. We have gathered the essential elements, namely different academic institutions in Europe (France, Germany, and Sweden) and their associated countries (Ukraine) as well as two European companies (Graphenea-Spain and LSO Medical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Deciphering the functions of Sox6 and myosin-encoded microRNAs in heart failure and hypertrophy' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

MicroRNAs (miRNAs) negatively regulate gene expression by promoting mRNA degradation and inhibiting mRNA translation. Recent studies have uncovered key roles of miRNAs as mediators of cardiovascular development and disease, but much remains to be learned about their mechanisms of action and regulation. Dr. Olson's lab has described a family of muscle-specific miRNAs, referred to as MyomiRs, which are encoded by introns of myosin heavy chain genes. These three miRNAs (miR-208a, miR-208b, miR-499) control pathological cardiac remodeling, muscle myosin content, myofiber identity, and muscle performance. Each of these miRNAs regulates the expression of Sox6, a transcriptional repressor. Consistent with a role for Sox6 as a mediator of the actions of MyomiRs, over-expression of Sox6 in skeletal muscle mimics the effects of MyomiR gene deletion and deletion of Sox6 in skeletal muscle recapitulates the phenotype of MyomiR over-expression. These findings have revealed a previously unrecognized role for Sox6 as a mediator of skeletal muscle gene expression, but nothing is known of its potential role in the control of cardiac gene expression or function. Given the importance of MyomiRs in regulating cardiac stress responses, and the regulation of Sox6 expression by MyomiRs, we postulate that Sox6 is a central regulator of cardiac hypertrophy and heart failure. The goal of this project is to define the mechanisms whereby Sox6 controls cardiac gene expression by idenfication of its downstream target genes and transcriptional cofactors and to explore its role as a mediator of the actions of myosin-encoded cardiac miRNAs. The project will benefit from a strong foundation of preliminary data and unique mouse strains (e.g. Sox6 knockout and transgenic mice) already established in the l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Synthesis of Functional Multi-Component Supramolecular Systems and Materials'.

assistant: **Innovation**

This ERC proposal targets novel synthetic strategies to arrive at functional multi-component systems and materials. They possess architectures of such high complexity that it is hard to imagine access to these systems by self-assembly or self-organization only. We will explore tools required to introduce multi-step non-covalent synthesis. We have taken inspiration from Nature, but more importantly we propose to mimic the impressive progress in the field of covalent organic and polymer synthesis. Three connected approaches are defined:   The first section focusses on supramolecular polymers and how their polymerization can be compared to that of traditional covalent polymerization; unprecedented similarities are foreseen. Unexplored areas like controlled co-polymerization and achieving “tacticity” in asymmetrically modified building blocks are proposed, with special attention to kinetics and structure characterization.     The second section is aiming at synthesizing a multi-component hydrogel leading to a system that is able to recruit receptors in a dynamic and reversible fashion. This work is proposed to culminate in new insights for preparing an artificial extracellular matrix for stem cell to organoid growth. The latter is proposed using a double supramolecular network.     The final section takes inspiration from the recent finding that chirality can control spin-selective chemistry. Novel chiral structures with control over pitch and diameter are proposed by two-step synthetic processes. In a three-step non-covalent synthetic procedure, a space-controlled arrangement of chiral quartets on surfaces is proposed using discrete block co-oligomers.   Since molecules only have structures and properties, their functions can only be expressed when they are part of complex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Formulation of immediate response and evacuation strategies through intelligent simulation assessment and large-scale testing' (FIRE-EXIT).

assistant: **Innovation**

FIRE EXIT proposes to equip the marine industry with a Ship Evacuation Simulator that is a quantum leap in the level of reliability, realism and design utility of today's ship evacuation software. The FIRE EXIT ship evacuation simulator will be capable of addressing issues of mustering, ship motions, fire and abandonment. In achieving these aims FIRE EXIT will take as its starting point the very leading edge of the current state-of-the-art in ship evacuation simulation, fire simulation and large-scale experimental facilities and significantly enhance these capabilities. The results of this project will include the development of fire and physical mechanisms enabling realistic simulation of ship motions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Relative Langlands Functoriality, Trace Formulas and Harmonic Analysis' (RELANTRA).

assistant: **Innovation**

The Langlands program is a web of vast and far-reaching conjectures connecting seemingly distinct areas of mathematics that are number theory and representation theory. At the heart of this program lies an important principle called functoriality, that postulates the existence of deep relations between the automorphic representations of different groups, as well as related central analytic objects called automorphic L-functions. Recently, a new and particularly promising way to look at these notions, and that has come to be called the relative Langlands program, has emerged. It essentially consists in replacing groups by certain homogeneous spaces and to study their automorphic or local spectra. As for the usual Langlands program, trace formulas are essential tools in the relative setting both to tackle new conjectures than to deepen our understanding of the underlying principles. A main theme of this proposal would be to make fundamental new contributions to the development of these central objects in the local setting notably by: (1) Studying systematically the spectral expansions of certain simple versions especially in the presence of an outer automorphism (twisted trace formula)  (2) Developing far-reaching local relative trace formulas for general spherical varieties making in particular original new connections to the geometry of cotangent bundles. These progress would then be applied to establish new and important instances of relative Langlands correspondences/functorialities. In a slightly different but related direction, I also aim to study and develop other important tools of harmonic analysis in a relative context, including Plancherel formulas and new kind of Paley-Wiener theorems, with possible applications to new global comparison of trace formulas and f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SFICAM: Ultrafast Fiber-Based Single-Photon Camera for Advanced Microscopy' (SFICAM) under Horizon 2020.

assistant: **Objectives**

Light microscopy is critical to many fields, from biology and medicine to technology development and industry. One important breakthrough that enabled the development of super-resolution microscopy was the development of enhanced cameras capable of recording low light-level images with single-photon sensitivity. However such gain in spatial resolution is compromised by low temporal resolution, since these cameras work at video rate or somewhat faster, while many applications require to characterize dynamics which could be a million times faster. We propose here a proof of concept demonstration of a technique that enhances the resolution of optical microscopy in both space and time by significantly enhancing camera frame rates while still retaining single-photon sensitivity.Our approach is to form a single-photon sensitive camera using an array of fibres to guide light into single-photon detectors. In this proof-of-concept of a Single-Photon Fibre-optics Camera (SFICAM), we shall demonstrate a device that could resolve light emitters spatially with nanometric resolution and temporally with nsec precision. We argue that even witha limited number of elements, and therefore with a small frame size, such cameras could be effective, by combining them with scanning laser microscopy techniques. In the course of this POC project we shall expand the small SFICAM already constructed during the project QUAMI using either individual single photon detectors or monolithic arrays of detectors,  and demonstrate its utility and advantage in several microscope modalities. We shall also pursue IP protection of our device and proactively search for industrial partners that will advance it to market.