RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DrugSynergy: A data-driven systems biology approach to optimize drug combination strategies' (DrugSynergy), addressing dissemination and exploitation.

assistant: **Impact**

The complex physiopathology of human chronic diseases includes networks robustness, feedback loops, and cross-talks, which may induce limited efficacy, resistance, and/or excessive toxicity of an individual drug. Learning how to combine drugs in order to improve treatment efficacy and lower undesired toxicity is a major biomedical challenge. Current strategies for drug repositioning and optimization of drug combinations have two man limitations: 1) they mostly use public data and databases, which are based on knowledge of individual drug stimuli and do not specifically analyze interactions, 2) they consider limited number of cellular outputs to analyze the response to a drug. In DrugSynergy, we will use an innovative systems biology large-scale data-driven approach to determine the interaction between two drugs at the highest possible resolution. Our computational analysis workflow has been extensively validated over the past years. It is now robust enough to be applied for the optimization of drug combinations.Our business development strategies will follow several possible non-exclusive scenarios: 1) service providing to pharmaceutical and biotech companies to optimize their own pipeline of drug combinations, 2) generate intellectual property (IP) through identification of new drug combinations, optimization of existing drug combinations by addition of innovative drugs through screening of small molecule libraries, including from our Institute. These goals will be achieved in an academic structure, through licensing new IP to industrial partners, or within a start-up company created around the innovative pipelines and know-how of DrugSynergy. These options will be explored with our business development and industrial partnership department.DrugSynergy is expected to h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'City Alternative Transport System' (CATS).

assistant: **Concept**

The CATS project objective is the final development and experimentation of a new urban transport service based on a new generation vehicle. Its major innovation is the utilisation of a single type of vehicle for two different usages: individual use or collective transport. This new transport service is aimed at filling the gap between public mass transport and private individual vehicles. It is based on two operating principles: the self service concept where small and clean urban vehicles are offered on a short term rental basis, and the flexible shuttle service where a variable length of vehicles convoy, driven by a professional driver, operates at fixed hours along a line on a permanent basis or on a case by case basis. Both these principles are integrated in a single service (composed of vehicles and stations) called Cristal.The final aim of this new service is a more efficient mobility in cities through a more balanced use of small clean vehicles and mass transport. This inclusive new transport system is well adapted to the needs of people with reduced mobility, young passengers and tourists. Four Cristal vehicles and two stations will be made available by Lohr Industrie to the project for experiments. The CATS project will investigate through an in depth mobility needs analysis, on-site demonstration and showcases, the impact of the introduction of such a new system in three different European cities (Strasbourg FR, Ploeisti, RO, Formello, IT).The impact on environment and especially on CO2 emissions, as well as the acceptance and the evaluation of market take-up of the system will be studied. CATS will complement the design and manufacture of the Cristal vehicle via a detailed definition of its operating principles and by a design of its urban settings (stations,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Buruli ulcer: multidisciplinary research for improvement of control in Africa' (BURULICO).

assistant: **Innovation**

Buruli ulcer (BU), a disease caused by Mycobacterium ulcerans, is a neglected disease of the poor in remote rural areas. BU is the third most common mycobacterial disease after tuberculosis and leprosy. It is most endemic in West Africa with incidences as high as 280 / 100,000, but cases occur around the globe. Currently, BU is treated by surgery - no anti-mycobacterial drug trials have been conducted. Surgery with wide margins resembles radical oncological surgery but this is not a modern therapy for an in fectious disease. Moreover, it is neither affordable nor sustainable in endemic regions; and it is poorly accepted among people in endemic areas. Indeed, fear for mutilating surgery has been identified as an important cause of patient delay, resulting in e ven more extensive lesions at presentation. Though mortality of the disease is low, morbidity and subsequent disability are very high, with up to half of those treated are left with disabilities that have long-term social and economic impact. New molecular tools are needed to explore epidemiology and transmission, and to improve diagnostics and treatment. This proposal is a multidisciplinary treatise that aims at the development of new tools and knowledge. In close networking of partners with different expe rtises the following activities are foreseen: 1) analysis of moleclar epidemiology of M. ulcerans, 2) analysis of environmental reservoirs and possible relationship to transmission, 3) evaluation of diagnostic principles with the aims of establishing guide lines, 4) treatment studies with the aim of establishing guidelines for therapy both with drugs and by surgery , 5) analysis of the in situ host response to obtain an understanding of the immune defense against M. ulcerans and to find possible correlates t o p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Investigating the role of pre-synaptic HCN1 channels in regulating cortical synaptic transmission and plasticity'.

assistant: **Concept**

Voltage-gated ion channels are important determinants of neuronal excitability. The Hyperpolarization-activated Cation Non-selective (HCN) channels are voltage-gated ion channels that open with hyperpolarization at subthreshold potentials. Four subtypes (HCN1-4) have been cloned. There is considerable interest in HCN1 channels as they have been shown to have roles in physiological processes such as learning and memory as well as pathophysiological conditions such as epilepsy. Many studies have shown that they are highly localised to hippocampal and cortical cell pyramidal cell dendrites. Interestingly, emerging immunohistochemical evidence suggests that they may also be present in axons and synaptic terminals. In support of this, our recent work shows that excitatory synaptic transmission is significantly enhanced in the entorhinal cortex (EC) in HCN1 null mice, suggesting that HCN1 channels may play a role in regulating neurotransmitter release. In the proposed work, we wish to test the hypothesis that HCN1 channels exist at glutamatergic synaptic terminals in the EC, where they regulate synaptic transmission. We also wish to investigate the cellular mechanisms by which pre-synaptic HCN1 channels may influence synaptic release. Finally, we wish to explore the physiological function of these pre-synaptic HCN1 channels. To address these questions, we will use a multi-disciplinary approach involving conventional electrophysiology, state-of-the art multi-photon microscopy imaging and electron microscopy coupled with transgenic mice and pharmacology. The results produced will have significant ramifications not only in the field of ion channels, particularly HCN channels, and neuron excitability but also for understanding the factors involved in controlling neurotransmission
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Space4Earth' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

GlobeEye provides a new, unique, and complete perspective on global economic, environmental, and social developments.Leveraging frontier technologies in space data and artificial intelligence, it delivers valuable insights for decision-makers in finance,business, and government. It contributes to overcoming out time’s major challenges, and arguably humanity’s greatest threats, ofclimate change, biodiversity loss, and natural capital depletion.In particular, GlobeEye is focused on developing next generation sustainability (ESG) metrics. Thanks to state-of-the art deep learningmodels, it combines satellite data with a vast range of remote sensing, ground-based, alternative, and observational data to generateunprecedented information sets and predictions. The result is independent, verifiable and actionable sustainability (ESG) indicators.ESG indicators have vast possible applications, both in the private and in the public sector, but are most crucial for green finance. Byproviding reliable data, GlobeEye enables and supports the transition towards green finance and sustainable investment decisions,risk management, and related regulatory efforts.Our Space4Earth proposal highlights how the Women Tech EU programme can GlobeEye step up to the next stage of growth andhow it comes at the perfect time for our development stage. The programme provides the needed funding, coaching and contacts totake the business planning and management steps to prepare the start-up for the next phase of funding and growth.


**Keywords:** Sustainability, Sustainable Development, Sustainable Growth, Climate Change, Green Finance, Green Growth,Artificial Intelligence, Satellite Data, Leadership, Planning, Diversity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Reinforced cooperation to provide operational flood forecasting and alerts in West Africa' under Horizon 2020.

assistant: **Concept**

Flooding is a rapidly growing concern in West Africa, projected to increase with climate change. It is both a threat and a blessing for human lives, agriculture and infrastructure. There is a great need for reliable access to operational flood forecasts and alerts produced by a robust information and communication technology (ICT) system adapted to regional conditions and operated by capable West African institutions.More than six years of cooperation between FANFAR participants have identified user needs and co-developed technologies and capacities aimed at meeting them. As a result, several ICT components of the desired system are already available, including input data streams, a hydrological model, a cloud computing platform, and a communication channel. However, they have not yet been fully integrated or adapted to the conditions and needs in West Africa (e.g. unreliable electricity and internet). Some components are already used by key West African institutions. However, e.g. human and financial capacity is still limiting uptake.The aim of FANFAR is to reinforce the cooperation between West African and European hydrologists, ICT experts, decision analysts, and end-user communities to provide a co-designed, co-adapted, integrated, and co-operated streamflow forecasting and alert pilot system for West Africa. End-users will participate in regular workshops and virtual meetings aiming to demonstrate the ICT, define user needs, co-design necessary adaptations, and develop capacity. Through this incremental refinement process, our existing ICT will be fully integrated and adapted to West African conditions. The system will be operated, supported and tested in practical flood management by regional, national and local institutions. Social science frameworks will be empl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Reducing Emissions from Deforestation and Degradation in Africa' under Seventh Framework.

assistant: **Concept**

Deforestation and degradation are estimated to contribute about 20% of global greenhouse gas emissions. A group of developing countries initiated a process at the UNFCCC Conference of Parties (COP-11) in 2005 to address the issue of reducing emissions from deforestation and degradation (REDD), that would be implemented as a post-Kyoto Protocol mechanism. Countries have been encouraged to develop REDD Pilot Projects to assess the feasibility of such a mechanism.  Earth Observation in combination with in-situ data are important tools for forest cover and land use monitoring in the REDD process. The current proposal REDDAF aims to develop pre-operational forest monitoring services in two Congo Basin countries that are actively involved in the REDD process. The users in both Cameroon and Central African Republic require such services and will actively participate in project implementation. The main activities proposed are:Stakeholder Analysis: country specific user requirements to identify the needs of stakeholders in terms of instituting REDD projects.Carbon stock accounting: research and development of methods for improved EO/ in-situ data applications to estimate areal extent of deforestation and forest degradation as well as biomass per unit area. The historical changes in forest cover will be used to establish a reference baseline. Based on these research efforts pre-operational processing chains will be developed.Technology Transfer/Capacity Building to the country: activities to ensure that project results, methodologies and lessons learned are provided in a manner to best support the work of national and regional counterparts.The services and products that will be delivered to the user community include forest cover maps and forest cover change maps for 1990-2000 an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Centre of Excellence in Science and Technology for Healthy Ageing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In order to both solve the medical needs of ageing-populations in Europe, and develop an innovative ecosystem beneficial for the economy of Lithuania, it is proposed to foster the whole innovation chain in the area of healthy ageing – from fundamental research through to the introduction of new products and services to the market - by creating in Lithuania a world-class Centre of Excellence (CoE) in science and technology for healthy ageing, named HEALTH-TECH.The long-term vision for HEALTH-TECH is to:- Become the leading provider of innovative medical solutions for the improvement of the health of ageing-populations in Europe,- Consolidate research and development, education and training, and networking and promotion resources activities in the area of healthy ageing, - Coordinate, integrate and support research excellence and innovation development in Lithuania, the Baltic Sea region, and Europe,- Support researchers, physicians, and entrepreneurs in the field of healthy ageing science, technology and biotechnology to produce innovations beneficial for the society and economy of Lithuania and beyond.To achieve this long-term vision, the CoE will leverage the knowledge, experience and resources of three Lithuanian universities – KTU, LSMU, and VU - with the support of two advanced partners of the Baltic Sea region – LUND in Sweden, and VTT in Finland - in four strategic research and innovation topics: 1. Mechanisms of age-related diseases2. Biomarkers for age-related diseases3. Diagnostics and monitoring technologies for age-related diseases4. Regenerative technologies for age-related diseasesThis project has the full support of the Lithuanian Government because it fits perfectly with the Lithuanian SMART Specialisation Strategy approved by the Government, and will all
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Metamaterial Enabled Vibration Energy Harvesting' (MetaVEH).

assistant: **Innovation**

Increasing demand for fully autonomous wireless sensors to service the emerging technologies of the internet of things, remote and real time monitoring of vulnerable environments or self-sensing smart structures is driving a requirement for efficient and novel methods of energy harvesting. The sensor's data communication has a substantial power requirement that presents a serious constraint upon the number of sensors, and their capability. Our primary aim is to realise innovative Lead-free electromechanical energy harvesters; these will be easily installed, to power, in a clean and low-cost manner, autonomous wireless sensing devices thereby eliminating batteries and human intervention: This will revolutionise sensor applications whilst simultaneously reducing chemical waste. This is timely as in current solutions battery replacement is either logistically impossible or too expensive and batteries carry a toxic chemical cost. Solar panels have the environmental drawback of using toxic materials. In our vision of future sensor technology, with our vibration energy harvesters (VEH) as their primary power source, a battery, will become unnecessary, and their associated chemical waste will no longer occur, and these sensors will become truly autonomous. The harvester's mechanical core will draw on advanced multiresonator designs, integrating Lead-free piezoelectric patches enhanced by the unique wave control capacities of resonant elastic metamaterials. Currently microVEH, though promising, suffers due to frequency mismatch: We have the ambition to bridge the gap between different scales by leveraging the potential of metamaterials. This will dramatically increase the energy available for harvesting, and operational bandwidth. For electronic applications the integration of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Intelligent Non-woven Textiles and Elastomeric Responsive materials by Advancing liquid Crystal Technology' (INTERACT) targeting Horizon 2020.

assistant: **Abstract**

A grand challenge in today’s materials research is the realization of flexible materials that are also intelligent and functional. They will be the enablers of true breakthroughs in the hot trends of soft robotics and wearable technology. The standard approach to the latter is to decorate rubber sheets with electronic components, yielding two serious flaws: rubber is uncomfortable as it does not breath and solid state electronics will eventually fail as a garment is flexed and stretched when worn. While the softness of rubber is ideal it must be used in the form of textile fibers to provide breathability, and for long-term failure resistance we need intelligent components that are soft. A solution to this conundrum was recently presented by the PI with the concept of liquid crystal (LC) electrospinning. The extreme responsiveness of LCs is transferred to a non-woven textile by incorporating the LC in the fiber core, yielding a smart flexible mat with sensory function. Moreover, it consumes no power, providing a further advantage over electronics-based approaches. In a second research line he uses microfluidics to make LC rubber microshells, functioning as autonomous actuators which may serve as innovative components for soft robotics, and photonic crystal shells. This interdisciplinary project presents an ambitious agenda to advance these new concepts to the realization of soft, stretchable intelligent materials of revolutionary character. Five specific objectives are in focus: 1) develop understanding of the dynamic response of LCs in these unconventional configurations; 2) establish interaction dynamics during polymerisation of an LC precursor; 3) elucidate LC response to gas exposure; 4) establish correlation between actuation response and internal order of curved LC