RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investing in Culture towards Economic and Social Development: International and European Law Perspectives', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Culture influences, and is influenced by, development. The protection of cultural heritage may foster development, understood both as economic development induced by a sustainable use of a state’s cultural patrimony, and human and cultural development sustained by a society’s sense of identity and continuity with the past. As foreign direct investment  (FDI) fosters economic development, there can be positive synergies between the promotion of FDI and the protection of cultural heritage. However, this is not always the case. This study aims to explore the complex interplay between cultural policies and international investment law with a special focus on the EU external relations. As there is an increasing tension between the two different sets of normative values, which is shown by the boom of relevant international disputes, this study aims at 1) mapping in a systematic and complete fashion the relevant investor-state arbitrations in order to give policy makers, arbitrators, stakeholders and the public at large a complete survey of the relevant case law; 2) proposing legal methods to reconcile these different values both de lege lata and de lege ferenda; and 3) scrutinizing and critically assessing the EU external policies concerning investment law and culture. The key objective of the study is to find ways to reconcile economic development with cultural heritage protection. The underlying thesis of this work is that reconciliation is possible, and that development should be conceived as a broad concept inclusive not only of mere economic growth, but also of human flourishing and well-being to which cultural elements are crucial. The Fellowship would allow the applicant to conduct this research, thus having a strong impact on her  scientific profile and her profession
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulation of cell adhesion, polarity and proliferation in mammalian epithelial celles by proteins of the discs large and crumbs group' (EPIADHESION).

assistant: **Innovation**

Epithelial tumours are characterized by a loss of their polarized cellular architecture, which is correlated with less adhesive and more migratory properties of the tumour cell. Genetic analysis in Drosophila melanogaster led to the identification of the bazo oka, crumbs and discs large group of genes implicated in the generation of cell polarity. In addition, the components of the discs large group, the tumour suppressor proteins Dlg/Lgl/Scrib are involved in the regulation of cell proliferation. However, the f unction of these genes in mammals is poorly understood.The proposed project aims to understand how the proteins of the crumbs and discs large group regulate cell adhesion in mammalian epithelial cells and how they contribute to cell polarity. Moreover, the studies are anticipated to identify the important linkage between the regulation of cell polarity and cell proliferation. The main approaches and methods for the research project is a wound healing migration assay and siRNA experiments. By using these as says, we will look at the biochemistry and cell biology of the de novo assembly of epithelial cell junctions. In particular, we will focus on the identification of the network of protein interactions between components of the bazooka, crumbs and discs large group and how these protein complexes contribute to cell junction formation and cell polarity. Furthermore, the role of Rho-family GTPases such as Rho, Rad and Cdc42 in the formation of cell adhesion will be assessed.Finally, the proteins Dig, Lgl and S crib are considered to have a potential function in the control of cell proliferation. We will dissect the molecular events by which these proteins link cell polarity and cell proliferation by using a combination of siRNA, microinjection and live-cell imagin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative Styling Applications in Computer Aided Environments' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives and content The development of computer-aided techniques has brought great strides in reducing the time and costs associated with engineering design, but similar advances have not been made in the use of computers as part of an integrated styling design process. While many of the needs of systems for styling design are shared With engineering design, there are significant and fundamental differences between the two design areas. While engineering designers may agree that computer-aided engineering design is almost adequate to their needs, the same cannot be said by styling designers. Not only are many of the fundamental tools and processes not yet existent, but it is difficult to connect those that do into a functional process for styling design. It is the purpose of the INSTANCE project to do the fundamental research that must be done, from both user-centred and system-centred viewpoints, to facilitate and encourage the development of useful and Creative computer-aided styling design. To this end, partners whose experience and Skills Span the Spectrum of knowledge around styling and concept design have come together to form the INSTANCE Consortium The industrial and scientific achievements include: - Development of techniques for combining surface and volumetric modelling (spline surfaces and voxel solids) to draw on the strength of each approach and prototyping a hybrid modeller using a voxel kernel With spline based tools to implement the developed techniques. This includes development of an appropriate interface to the modeller using Virtual Reality. - Integration of rapid prototyping processes into computer-aided styling to implement an approach for manufacturing early 3D sketches of a design. This includes a direct interface to the hybrid voxel represen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'X-Ray Fluorescence Imaging of Metal Complexes in Hypoxic Tumor Spheroids' (ImageTumor), addressing dissemination and exploitation.

assistant: **Impact**

According to estimates from the World Health Organization (WHO) in 2019, cancer is the second leading cause of death after heart failure before the age of 70. The field of metal-based anticancer drugs has been on the rise ever since the discovery of the anticancer properties of cisplatin in 1965, which is in daily clinical use against various types of cancer. Many compounds failed to enter clinical studies since their anti cancer activity is mainly studied in two dimensional (2D) monolayer cells which does not mimic the complex tumor micro environment in humans. In the human body the cancer tumors grow in 3-dimensional structure, hence it is vital to study the anticancer activity of a drug molecules in the 3D tumors rather in 2D mono layer cells. Next, tumor hypoxia (1% Oxygen), a situation where tumor cells are deprived of oxygen, is a major challenge for oncology. In this project we propose the synthesis of N-Heterocyclic Carbene/1,8-naphthalicanhydride conjugated series of metal complexes (Gold, Rhodium, Iridium) to study the anticancer activity and penetration depths in 3D tumor spheroids under hypoxia. We also investigate the activation by reduction mechanism in presence of cellular thiols and cytotoxicity in vitro (3D cell spheroids) and compare the results among the three metal centers. The metal protein interactions play key role in many biological processes; hence we also investigate the metal-protein interaction studies using capillary electrophoresis inductively-coupled mass spectrometry (at secondment). We will investigate the structure activity relationship between metals and of related coordinating ligands in 3D spheroid under hypoxic conditions. We mainly utilize X-Ray Fluorescence (XRF) imaging and synchrotron radiation to test the cellular localizations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Astroglial control of axonal excitability, adaptation and  analogue signalling' in the context of a Horizon 2020 call.

assistant: **Objectives**

Evidence has been emerging for astrocytes to play an important role in neuronal cooperation and information processing in the brain. Recent work has suggested that their activity may even regulate the shape of action potentials in the axon and thus the efficacy of synaptic transmission. However, the underlying physiological machinery remains poorly understood. We propose here that astrocytes play an active role in the analogue-digital regulation of presynaptic signalling. To decipher the role of astroglia in presynaptic signalling, in particular analogue-digital axonal information transfer, we focus on the giant mossy-fibre-CA3 synapse, well characterized in the host laboratory. Our working hypothesis is that astrocytes regulate spike generation and propagation in axons by modulating local extracellular potassium and possibly by releasing glutamate. To test this hypothesis, an innovative set of technique will be used: i) direct recordings of astrocytes and either presynaptic or postsynaptic elements of the synapse in the mossy-fibre to CA3 synapse; ii) genetic tools allowing specific targeting and stimulation of either astrocytes or neurons; iii) pioneering imaging tools, such as FLIM, to directly measure the calcium entry and glutamate-sensing fluorescent reporter to reveal glutamate release by the astrocytes. The proposed project should unravel the mechanisms by which astrocytes control axonal information transfer in neural networks axonal excitability while shedding light on poorly understood features of astrocyte physiology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Slow motion: Transformations of musical time in perception and performance' (SloMo) under Horizon 2020.

assistant: **Objectives**

Slow motion is widely employed in popular media such as emotional movie scenes or in the broad-casting of momentous bodily and physical actions. Slow motion functions as a counterpoint to the perceived acceleration of life, and non-profit organisations and meditation practices promote its virtues. Slow motion is used as a beneficial rehearsal strategy in music, dance, and other movement-based arts and sports. This research proposal shifts existing boundaries by hypothesizing that the time-stretching mechanism of slow motion is a) associated with high emotional significance, b) beneficial for interpersonal coordination, c) relevant in cross-modal approaches with augmented feedback such as the sonification of human movements, d) reduces cognitive working memory load in learning. It is assumed that music as a temporal-motional art is central for the study of these processes, since music consists of structured time at different hierarchical levels and deeply “moves” people. The musical surface structure (on a note-to-note level) allows synchronisations at higher tempi compared to deeper structural levels (such as strong beats in a measure or phrases). Music may thus transform perceptions of motion and time. The proposed project contains three main phases, first addressing the perception of slow motion in music and dance in relation to the attentional, emotional and aesthetic effects on the audience. In the second phase, performance qualities are studied, addressing cognitive load, imagery, and interpersonal coordination at slow tempi. High-speed cameras, a 3D motion capture system and physiological measures are used to analyse the psychological and bodily processes involved. The final phase aims at the creation of three applications, including a learning app for portable de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Correspondences in enumerative geometry: Hilbert schemes, K3 surfaces and modular forms' (K3Mod).

assistant: **Innovation**

Enumerative geometry is concerned with counting geometric objects on spaces defined by polynomial equations. The subject, which has roots going back to the ancient Greeks, was revolutionized by string theory in the 90s and has since become a fundamental link between algebraic geometry, representation theory, number theory and physics. With K3Mod I propose to establish a wide range of new correspondences in enumerative geometry. These link together different enumerative theories and open new perspectives to attack long-standing problems concerning the quantum cohomology of the Hilbert scheme of points on surfaces, modular properties of invariants of K3 surfaces, string partition functions of Calabi-Yau threefolds with links to Conway Moonshine, and a major case of the Crepant Resolution Conjecture.The geometry of the Hilbert scheme of points on a surface will play a central role. I aim to prove a correspondence between its Gromov-Witten theory, and the Donaldson-Thomas theory of certain threefold families. Correspondences for moduli spaces of Higgs bundles and the orbifold theory of the symmetric product of surfaces will be considered as well. This provides methods to prove that Gromov-Witten invariants of Hilbert schemes of points on K3 surfaces are Fourier coefficients of quasi-Jacobi forms, possibly leading to a complete solution of their enumerative geometry. After elliptic curves, K3 surfaces form the simplest Calabi-Yau geometry for which a complete understanding of the Gromov-Witten theory is in reach. For elliptic threefolds, I will study the relationship of their Donaldson-Thomas invariants with quasi-Jacobi forms, using both degeneration techniques and wallcrossing formulae. The research goals of this proposal will lead to exciting new connections between geome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HYDRODYNAMIC TRANSPORT IN ECOLOGICALLY CRITICAL HETEROGENEOUS INTERFACES' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Physical, biochemical and ecological processes in natural water bodies have been the subject of intense research over the past decades by scientists of different expertise. Environmental studies related to natural water bodies are a relatively new area of research, spanning over no more than fifty years. The dawning of environmental studies in the late 20th century has seen developments mainly confined to individual classical areas of expertise, with relatively small degree of interactions among specialities. The development of a truly interdisciplinary approach to environmental studies in a holistic perspective appears one of the main challenges of the new century. This project aims at the training of new technical and scientific figures which can bring innovation in environmental applications and problem solving. The training activity will cover the transport of inorganic and organic matter, including solutes, colloids and sediments in river flowsand across the boundary interfaces. Understanding of transport mechanism is a predestined stepping stone towards the ability to assess the vulnerability of the natural environment to anthropogenic stresses. The crucial role of heterogeneities of the stream geometry, of thenature and composition of interfacial matter, and of transported matter, will be emphasized by appropriate experimental and mathematical tools. Direct observations and measurements of transport and ecological processes, using up-to-date instrumentation and investigationprocedures, will play a major part in the research and training programme. The participation of the private sector in the training activities will be a key element to guarantee the direct transfer of methods and results into the professional and technical market. The trainees will buildspecifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Palaeobiological inference through phylogenetic analysis of Pleistocene deer' under Seventh Framework.

assistant: **Concept**

The present research aims to reconstruct the phylogeny of Plio-Pleistocene European deer and to use it as a case study of “adaptive radiation” to try to understand some classic palaeobiological questions such as the link between diversification and environmental change, the origins of endemism, size fluctuations within lineages, and the evolution of sexual organs (antlers) in relation to factors such as habitat and body size. Deer are very abundant in the European Pleistocene and their marked species turnover and high rate of evolutionary change make them useful biochronological indicators and a good example of adaptive radiation. However, a clear understanding of their evolution is biased by their confused taxonomy, and the number of identified remains is reduced by the fact that their systematics is mainly based on antler and cranial morphology, not taking teeth and limb bone morphology into account. I will therefore first review the confused taxonomy of the Pleistocene deer, with special regard to the Megacerini (giant deer) and to the Dama-like deer (fallow deer) also assessing relationships with other taxa, by re-examining the original descriptions and re-studying key specimens from Britain and the continent. Then I will determine metric and non-metric morphological variation in the dental and postcranial remains using articulated skeletons from key sites in Western Europe as a guide. A cladistic analysis based on all available non-metric characters will provide a systematic framework for the exploration of palaeobiological questions. Chronological calibration will allow assessment of speciation rates in relation to environmental change. Geographical and chronological variation in size and adaptive form will be interpreted in relation to climate, habitat and guild
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular pathogenesis of a novel thyroid hormone resistance syndrome caused by mutations in thyroid receptor alpha 1' in the context of a Seventh Framework call.

assistant: **Objectives**

Thyroid hormone (TH) is crucial for the normal development and metabolism of all tissues. The actions of the bioactive T3 are mediated by binding to its nuclear receptors (TRs), of which TRa1 and TRb1 are the main isoforms. It is known for decades that mutations in TRb1 result in resistance to TH, among others characterized by goiter and tachycardia, and abnormal TH levels.Ever since its characterization in 1987, investigators have searched for patients with mutations in TRa1. However, very recently the host and applicant’s laboratory independently discovered the first patients with inactivating mutations in TRa1. These patients show growth retardation, delayed bone, motor and mental development as well as abnormal TH levels.The patients display remarkable differences in neurological, bone and biochemical phenotype. Interestingly, all mutants are located within exon 9, which encodes a domain important for ligand binding and interaction with co-activator and co-repressor proteins. It is likely that mutant-specific properties underlie the differences in clinical phenotype.The aim of this project is to unravel the molecular mechanisms leading to the clinical phenotype of patients with TRa1 mutations. The key objectives are: (i) to study direct effects of mutations in a reporter assay; (ii) to detail consequences of mutations on downstream target genes; (iii) to identify alterations in the interaction of the receptor mutants with cofactor proteins and (iv) to establish a genotype-phenotype relationship.Using an integrative approach with well-established and advanced techniques, this scientifically fascinating project will certainly deepen our understanding of the role of TRa1 in health and disease.The combination of the longstanding expertise of resistance to TH in the host