RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Resource Efficient Maritime Capacity' (REMCAP).

assistant: **Concept**

The global maritime market is on a strong growth trajectory, and this project aims to harness that growth to create economic and employment benefits for Europe.  On the one hand, growth is driven by commercial megatrends such as demand for marine/offshore renewable energy, fish products and emerging potential for ‘blue biotech’ products; on the other hand, there is high demand for efficient use and management of the ocean resource, as described in the EU Integrated Maritime Strategy.  Increasing Europe’s innovation capacity in maritime resource efficiency will underpin successful exploitation of these growth opportunities.Traditionally, the maritime industries have been slow to explore how demands for resource efficiency would impact on them.  Fish stock depletion and rising fuel costs have, of course, risen quickly up the political and commercial agendas, and shipping companies as well as builders and engine manufacturers have invested in improving fuel efficiency.  However, the wider needs for maritime resource efficiency are posing challenges which in many cases lack viable solutions.  Emerging marine activities (for example in exploiting marine renewable energy) are presenting new opportunities for innovation, but are also highlighting areas where further improvements in resource efficiency need to be achieved.European member states contain a number of Regional Research Driven Clusters (RRDCs) which are active in the fields of maritime development and marine & coastal resource management.This project will add significant value to this existing cluster infrastructure, via three main approaches that will support their long-term development and sustainability:•Facilitating interaction and knowledge exchange between RRDCs each focused on its world-class strengths (Smart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Active Balancing Power Converters for Photovoltaic Energy Systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project is within the framework of power electronics applications for photovoltaic (PV) energy systems, which play a key role in the generation and storage of carbon-free energy.The main objective of the project is the development of new, smart PV modules, enhanced thanks to the intelligent useof power electronics devices. These power electronics devices replace bypass diodes and allow differential power processing between submodules (or substrings) in order to mitigate mismatch effects due to partial shading, soiling, temperature gradients, manufacturing tolerances and ageing. As a result, the proposed smart PV modules will be virtually immune to mismatch and will be able to operate during more years. This will increase the energy yield of PV systems, while decreasing cost and easing the operation of downstream power electronics.The proposal focuses (i) on the development of a comprehensive cell-level simulation tool for the prediction and evaluation of the advantages of the new PV modules and their optimal design, and (ii), on the high-power density realization of the power electronic devices, considering the results of objective (i).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Enhancing the innovation management capacity of SMEs in North Rhine-Westphalia, Germany' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project is to be understood as a supplement to existing Enterprise Europe Network activities in North Rhine-Westphalia as well as preparation for future ones. For the period April to December 2014, ZENIT will undertake – as part of the existing NRW.Europa project – the additional task of “Enhancing the innovation management capacity of SMEs”.This task consists of two service packages pre-defined by the European Commission / EASME and foreseen for a limited number of enterprises: 1. Beneficiaries of the SME Instrument of Horizon 2020 (Key Account Management, KAM)2. SMEs with significant innovation activities and a high potential for internationalization (promising SMEs with gaps in the innovation management system)Whereas the first action is reserved for beneficiaries of the SME instrument with a dedicated coaching scheme, the second action is targeted at highly promising, innovative enterprises, which will be assisted with a two-step support scheme:1. Recording, analysis and evaluation of the individual status quo and of fundamental requirements and possibilities as well as of the threats and risks of the participating enterprises (analysis of needs and gaps, SWOT analysis).2. Development and implementation of individual concepts, measures, and activities (action and / or coaching plan). ZENIT considers a combination of self-assessment and interview with a senior consultant to be the most effective solution for the first stage and to fulfil the requirements of CEN / TS 16555-1 (innovation management system).


**Keywords:** Two Consultancy Services for SMEs: a) Key Account Manager for SMEs participating at the SME-Instrument, b) Innovation management for promising SMEs with European Added Value
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Engineering rice for resistance to insects'.

assistant: **Objectives**

The striped stemborer (SSB) (Chilo suppressalis) is one of the major constraints affecting rice production in the south european countries, causing yield losses reaching 15 to 20% in Spain and France. To address this problem, heavy chemical treatments as well as sprays with Bacillus thuringiensis insecticidal formulations have proven to be respectively environmentally damaging and of limited efficiency due to their poor persistence and to the biological localisation of the pest which develop in the rice culm. Conventional breeding for that trait has proven to be difficult.  The goal of this project is to develop SSB-resistant rice through transfer of Bacillus thuringiensis (B.t.) genes encoding insecticidal toxins and plant proteinase inhibitor (p.i.)genes into the 2 most widely released rice varieties in Italy, Spain and France. This project comprises: i. the use and synthesis of sequence-optimized B.t. toxin genes encoding proteins previously identified as specifically active against SSB larvae by affinity and toxicity tests - ii. the use of maize and soybean protease inhibitor genes - iii. the construction of vectors for expression of the transferred genes in rice plants, including constitutive promoters conferring high level expression to foreign gene in transgenic rice plants, a vascular tissue-specific promoter of the maize streak virus and wound-inducible promoters of maize and tobacco genes - iv. the use of transformation systems optimized for 2 Mediterranean elite varieties based on particle bombardment into scutellar cells of immature embryos and embryogenic calluses - v. the production and bioassay for SSB resistance of transgenic plants containing; a single B.t. gene; a combination of two B.t. genes under the control of a constitutive promoter;one or two B.t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum Annealing for Fluid Antenna MIMO Systems' (QUARTO).

assistant: **Concept**

Multiple-input multiple-output (MIMO) technology transformed wireless communications. However, the extreme requirements of the envisioned 6G services and the highly complex and dynamic radio environments of next-generation wireless networks call for better exploitation of the spatial channel dynamics and adaptation to rapid channel variations. Fluid antenna systems (FAS) have been recently proposed in response to these issues. They leverage liquid antennas whose position can be adjusted in real-time to enhance reconfigurability and, therefore, improve capacity, reliability, energy harvesting, and interference management. Nevertheless, antenna positions optimization is a particularly challenging problem that cannot be efficiently tacked by conventional means, especially given the excess of possible positions required to unlock FAS potential. Quantum computing alleviates this processing bottleneck.   Based on the above, QUARTO Proof-of-Concept (PoC) aims at developing and validating through D-WAVE experimentation a novel FAS-based and Quantum Annealing (QA)-enabled MIMO communication paradigm. QUARTO focuses on establishing the effectiveness of a proposed pre-processing technique for large-scale quadratic unconstrained binary optimization (QUBO) problems, experimentally validating the QA-based antenna configuration solution for FAS-based MIMO systems, demonstrating its benefits in comparison to the state of the art, and exploring its commercial potential. The project will benchmark the pre-processing technique on classical graph problems, such as MaxCut, scaling from 100 up to 2,000 variables, and will test the QA-based solution on MIMO configurations with up to 100 liquid antennas and ports.The proposed solution provides new R&D directions in quantum computing and 6G wir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Allostery in Drug Discovery' (ALLODD).

assistant: **Innovation**

Most current drugs are designed to bind directly to the primary active sites (also known as orthosteric sites) of their biological targets. Allosteric modulators offer a powerful yet underexploited therapeutic approach. They can elicit a richer variety of biological responses and, since they target less conserved binding sites, higher selectivity and less adverse effects may be obtained (Changeux, Drug Disc Today 2013). This proposal aims to train a new generation of scientists in exploiting the concept of allostery in drug design, putting together a whole array of technologies to identify and characterize allosteric modulators of protein function that will be applied to therapeutically relevant systems. Our approach is based on a combination of experimental and simulation techniques, including fragment Screening with structural characterization (X-ray, NMR, H/D exchange), proteomics (MS/MS), ITC, DNA encoding libraries, Virtual Screening, Molecular Dynamics simulations-based methods, Synthetic Chemistry, and in vitro and cellular assays for the verification of results. It should also be noted that allosteric targeting need not be achieved solely through the design of synthetic small molecules but also can also be reached via conformationally specific allosteric antibodies, which represents an important field of future research. There are already clear examples of monoclonal antibodies that allosterically target ion channels (Lee et al., 2014b), GPCRs (Mukund et al., 2013), and RTKs (De Smet et al., 2014), as well as cytokine and integrin receptors (Rizk et al., 2015; Schwarz et al., 2006).


**Keywords:** allostery, allosteric inhibitors, structure-based drug design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Illuminating radial genome organization in the nucleus'.

assistant: **Concept**

In exciting preliminary experiments leveraging our GPSeq method we discovered that the genome of mammalian cells in interphase folds into a steep radial gradient of guanine and cytosine (GC) density, which seems to persist at the level of individual mitotic chromosomes. However, we still lack a fundamental understanding of how this higher-order 3D genome architecture is established and what its functional implications are. Here, I go beyond the state-of-the-art and propose that the observed steep radial GC-gradient is a universal design principle of the radial arrangement of the genome in the nucleus—which I call the radiality principle—that provides a biophysical framework for spatially orchestrating key nuclear processes, beyond gene expression regulation. To test this hypothesis, in this project I pursue five Objectives: (1) First, we develop a novel approach (GP-C) for high-resolution single-cell 3D genome reconstructions to study whether the radial GC-gradient is indeed a universal property of nuclei across different species and cell types. (2) Next, we apply GP-C together with RNA-seq to monitor genome radiality and concurrent gene expression changes as cells undergo karyotype rewiring or significant epigenetic perturbations. (3) In parallel, we develop innovative approaches to probe the internal structure of mitotic chromosomes and model how genome radiality is reorganized as cells traverse mitosis. (4) We then expand our preliminary finding of large-scale DNA-RNA contact hubs that seem to shape cell-type specific radiality landscapes by opposing the radial GC-gradient. (5) Finally, we pioneer methods for profiling nuclear proteins radially and apply them to test the bold hypothesis that the radiality principle provides a blueprint for organizing numerous nuclear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of an innovative Airway-on-Chip microbiome cell culture model to investigate host-microbiome interactions at the airway epithelial surface'.

assistant: **Objectives**

Patients with chronic inflammatory lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence of respiratory infections. These infections accelerate disease progression and are associated with substantial morbidity and (especially in COPD) even mortality. Recent studies show that the airway microbiome of patients with asthma and COPD is different from that of healthy subjects. In murine lungs this has been shown to promote airway inflammation and loss of lung function. To this point it is unclear how changes in microbiome composition contribute to susceptibility for respiratory infections. Currently, treatment of patients with asthma and COPD is limited to symptom reduction and prevention of disease progression and hampered by the large amount of patients resistant to corticosteroid treatment. Understanding why these patients have an altered microbiome and increased susceptibility to respiratory infections is therefore pivotal to develop more effective healthcare strategies. Studies on host-microbiome interactions are mostly performed in murine models of airway diseases. Unfortunately, these models often fail to accurately reflect human disease. However, the recent development of Organ-on-a-Chip technology has effectively recapitulated many features of the modelled organ, thereby adding a level of complexity to cell cultures that is urgently needed. In contrast to existing airway epithelial cell cultures, these models contain several cell types, cultured at the air-liquid interface under a constant flow of air and nutrients while exposed to mechanical stress. However, also these cultures still lack an essential component of the airways: the airway microbiome. Therefore, the work described in this proposal aims to create an inn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ESMER - AN EXPERT SYSTEM FOR MULTIPHASE FLOWRATE MEASUREMENT' in the context of a Fourth Framework call.

assistant: **Objectives**

The project aims to produces a multiphase flow meter for use in oil production lines. The flow meter will be applicable under a wide range of flow conditions and it will have low capital and maintenance cost as the proposed meter is based on an innovative turbulence signal analysis and classification technique which allows the use of simple pressure sensors. The flow meter will be capable of measuring individual phase flow rates of oil and gas with approx. 5% and water cut with approx. 2% accuracy.The utilisation of the meter in oil production lines will remove the need to separate the fluids in expensive separator systems near the well head. The capability to meter multiphase fluids will allow lighter off-shore fluid handling platforms and structures and will achieve major cost savings for the oil producers.The prospects of technical viability of the technology is very high. The technique has already undergone five years of laboratory development in an atmospheric flow loop at the Imperial College of Science and Technology. This was followed by an industrial development and testing programme of two years, during which a spool piece was constructed in accordance with oil pipeline safety requirements and subjected to tests in a high pressure laboratory. The prototype was constructed upon specification of Shell Expro (UK) Ltd for intended field trials on an oil platform. The economical viability of the technology is very promising due to the low cost of the sensors and other materials of construction. The principal component of the technique is its signal processing technology which is embodied in a software code.We estimate that in mass production", the unit cost of the flow meter will be around £25000. Compared with the cost of the prototype this represents a major cost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Dynamics of Cadmium concentrations in Leaves in response to a challenging Environment'.

assistant: **Innovation**

Metal hyperaccumulator plants accumulate extraordinarily high concentrations of toxic metals in their leaves. The large within-population variation in the extent of hyperaccumulation of some metals in the field remains unexplained. Is this an acclimation, and to which environmental factor? Or is it a result of evolutionary adaptation, and what selects for it? To answer these questions, the applicant will employ results from a large field survey of Arabidopsis halleri, a model species capable of hyperaccumulating cadmium (Cd), published by the host group. The researcher will monitor dynamics of leaf Cd accumulation in the A. halleri populations exhibiting the largest intra-population variation in this trait in the field. In individuals contrasting for the degree of Cd accumulation, the researcher will quantify the response to herbivore attack, as well as the genetic contribution for leaf Cd accumulation. High-quality research in the host laboratory (Ruhr University Bochum, DE) and knowledge on soil-plant-insect interaction will enhance EU scientific excellence. The researcher will engage in collaboration with a secondment (Bielefeld University, DE) for scientific exchange and the synergic transfer of high-quality complementary scientific and methodological expertise, thus strengthening EU internationally leading position in toxic metal ecology. Expected results will enable best protocols for plant-based clean-up (phytoremediation) of metal-contaminated soils that are unsafe for agriculture and a significant issue in the EU. This project will delineate the inter-disciplinary independent career of the researcher, enhance his knowledge and provide personalised training in state-of-the-art research methodology. He will participate in management and group meetings and train s