RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'High performance MULTIphase Anaerobic Digester for agroindustrial wastewater treatment'.

assistant: **Innovation**

Food & Drink (F&D) industry is one of the most water consuming sectors, and is considered one of the largest producers of wastewater, producing roughly 2.17 million m3/day of wastewater in Europe. This is the largest manufacturing sector in EU, composed mainly by SMEs (>99%). Technically, anaerobic digesters are NOT optimised for small volumes (<1,000 m3). So, most industrial wastewater treatment technologies are optimised for much larger volumes (average: 2,500 m3). Economically, these technologies are very expensive (>1M€). Thus, only big companies implement anaerobic digestors. Until now. In AEMA, we have been able to downscale a disruptive small scale anaerobic digestor for wastewater treatment, addressed to F&D industry: Multi-AD.Multi-AD is a high performance MULTIphase Anaerobic Digester tailor-made for treating wastewater generated in Food and Drink SMEs. It is fully sensorised, being able to self-regulate basic operational parameters (T, flow…) for its auto-operation depending on the kind of wastewater characteristics it needs to treat. It will generate 80% methane-rich biogas that be partially used -50%- for its operation, and partially used -50%- for other energy-demanding industrial tasks (e.g. heating, at the industry choice), with average economic savings of 15,000€/year (when treating 100 m3/d) and 11% less CO2 emissions. We will commercialise it in the most important EU28 countries in terms of F&D industry, and as well in some countries in Latin America, being the flagship product for our internationalisation.  We plan to sell in the first five commercialisation years 108 units of the device, what will imply that we will sum up to AEMA’s team 14 persons. The project will have a ROI of 2.82. This Multi-AD project will contribute to ensure the safe and eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Adaptive Dynamics of the Maternal Immunity in Human Skin During Pregnancy' under Horizon Europe.

assistant: **Concept**

A successful immune adaptation to pregnancy is essential to support mammalian reproductive fitness. Pregnancy presents a immunological dilemma where the maternal immune system must tolerate fetal antigens while maintaining its main protective functions. How the maternal immune system navigates these opposing demands and adapt to pregnancy remains largely unclear. This question is of importance at barrier sites such as the skin that represents a primary portal of infection and inflammatory disorders. Clinical observations support the idea that skin physiology and immunity are altered during pregnancy. Using experimental models, the host laboratory uncovered a remodeling of skin immunity during pregnancy associated with a significant increase in regulatory T cells and an altered dendritic cell network. The goal of our proposal is to understand how pregnancy impacts human skin with the ultimate goal to develop approaches to mitigate inflammatory responses during this critical stage. More specifically, this project aims at exploring how pregnancy impacts human skin immune landscape and putative function both at steady state and in the context of inflammation. This high dimensional analysis will be performed using high resolution transcriptomic technologies including single cell ATAC / RNA sequencing and spatial transcriptomics. My expertise in these approaches will enable me to uncover underlying putative signalling pathways underlying immune cell changes and highlight pregnancy associated altered cell interactions. Candidate pathways will be validated using organoids mimicking pregnant skin. The generated data are expected to capture, for the first time, how the skin adapts to pregnancy. This work may provide fundamental insights into our understanding of maternal immunity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Gender Aspects of Screen Adaptations of the British Nineteenth-Century Female Literary Canon'.

assistant: **Objectives**

The aim of the project is to analyse the gender aspects of British and American screen adaptations of selected nineteenth century women’s novels. As the contemporary popular culture is increasingly reliant on adaptation and other derivative types of cultural texts such as sequels, retellings, and pastiche, it becomes vital to study the continued appeal of canonical literature. The project aims to study screen adaptations released between 1990 and 2010, which are internationally known and became parts of the shared collective cultural experience, influencing the popular perception of European nineteenth-century culture and the position of women within that culture. The project will consist of four components: (1) studying the adaptation authors’ (directors, screen writers etc.) stated motivations and perceptions of the original writers, revealed in interviews, DVD commentaries and other ancillary materials; (2) analysing the nature of “novel to film” changes, with special attention to the portrayal of female characters and the issues of women’s agency and empowerment; (3) studying the role of the visual elements, e.g.  costumes, scenography, cinematography and editing in the portrayal of female characters (4) analysing the receptions of adaptations and studying the possible “film to novel” transmission. The proposed research project is highly interdisciplinary in nature, aiming to use in a complementary way the perspectives of adaptation studies, gender studies and reception studies and film studies. It is based on solid theoretical founations (understanding he nature of the transmedial shift), but also involves a case-study approach to the chosen novel-and-adaptations clusters. Its expected impact is to offer a comprehensive analysis of the issues of women’s agency and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Define a lead candidate for clinical development of a novel T cell therapy'.

assistant: **Objectives**

Acute myeloid leukemia (AML) is a disease with a poor prognosis, especially for such patients either failing initial treatment or relapsing thereafter. In AML, specific immune cells such as T cells have been proven to bear curative potential in the context of stem cell transplantation but toxicity and therapy failure are frequent. The use of T cells modified for specificity with chimeric antigen receptors (CAR) has changed the landscape of several blood-borne cancer of the B cell lineage. In AML, however, ongoing development of CAR T cells is associated with severe toxicities, limiting dosing and efficacy because of poor specificity of used targets for AML blasts. In my ERC funded research, I have identified unique AML targets which are not shared with healthy hematopoesis or other relevant healthy organs. Developing CAR against these, I could demonstrate the potential of my strategy. To enable clinical development and exploitation, T2LEAD will identify and develop lead CAR candidates for further translation. T2LEAD will explore the medical and commercial potential of lead CAR and route exploitation towards licensing or spin out or both. T2LEAD will be supported by a strong network of advisors from academia, industry and regulation frame work. Ultimately T2LEAD will help advancing the treatment landscape in AML to the benefit of AML patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on '3D Printed Membrane and Bioremediation for the Reduction of Per- and Poly-fluoroalkyl Substances Pollution in Aquatic Ecosystems'.

assistant: **Innovation**

The presence of per- and polyfluoroalkyl substances (PFAS) in water bodies has adverse impacts on human health and ecosystems and is one of the main concerns regarding the EU green economy's growth based on zero pollution. Because PFAS can resist conventional water treatment processes, it is essential to develop alternative technologies based on advanced materials for their complete mineralization into CO2 and H2O.Among several approaches, photocatalysis using nanoparticles can degrade many recalcitrant pollutants but presents a lower capacity for their mineralization and a time-consuming and expensive recovery process of particles. In contrast, bioremediation has successfully achieved the defluorination of some PFAS compounds, but it is a relatively slow process.In this context, this proposal intends to apply 3D printing technology to produce novel and reusable multilayered polymer membranes incorporating photocatalysts and then develop a forefront hybrid water treatment technology combining for the first time photocatalysis and bioremediation to solve the urgent environmental threat, ensuring the effective degradation and maximum mineralization of PFAS in different aquatic matrices.Hence, this project aligns with the European Green Deal, 2030 Agenda, and EU Missions to reach a non-toxic environment. It will be completed in multidisciplinary research environments such as nanotechnology, additive manufacturing, photochemistry, and environmental biotechnology, using interdisciplinary efforts to engineer a revolutionary environmental remediation technology. The applicant brings photochemistry, environmental, and materials science knowledge to the research group and will acquire expertise in 3D printing technology, bioremediation, and ecotoxicity. The proposed work will ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Soraprazan - a new regenerative therapy for Stargardt's disease' (Soraprazan).

assistant: **Concept**

Soraprazan  – a new regenerative therapy for Stargardt’s diseaseAbnormal accumulation of lipofuscin in the RPE cells is a hallmark in Stargardt's disease. As lipofuscin cannot be removed from the RPE cells in the eyes neither spontaneously nor with existing therapies, the accumulation of lipofuscin in the RPE cells of the eyes results in the degradation of the RPE cells and consequently in worsening of visual acuity and could lead to blindness. Soraprazan was able to show removal of lipofuscin in RPE cells. Aim of the phase II trial in this project is to evaluate savety and efficacy or orally taken Soraprazan treatment compared to placebo.


**Keywords:** lipofuscin, vision loss, depigmentation, regenerative, RPE cells, Stargardt's disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Clinical translation of a novel CD1a-directed CAR for relapse/refractory cortical  T-cell Acute Lymphoblastic Leukemia: feasibility, efficacy and safety' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Immunotherapy has revolutionized cancer treatment over the last decade. Adoptive cell immunotherapy with T-cells genetically redirected to a tumor-specific antigen using a chimeric antigen receptor (CAR) has achieved impressive response rates in advanced B-cell acute lymphoblastic leukemia (B-ALL). CAR T-cell strategies beyond B-cell tumors are, however, hampered by expected toxicities, owing to the lack of bona fide therapeutic and safe antigens. Indeed, there are no immunotherapeutic therapies (including CAR T-cells) approved for T-cell malignancies (T-ALL or T-cell lymphomas), as the shared expression of target antigens between CAR T-cells and T-blasts induces CAR T-cell fratricide and T-cell aplasia, leading to fatal immunodeficiency. We recently identified the CD1a antigen as a safe target for CD1a+ cortical T-ALL (coT-ALL), a major subgroup of T-ALL, and we have developed a novel CD1a-specific CAR. Results generated from my previous ERC-funded work (INFANTLEUKEMIA nº646903 and IT4-BALL nº811220) have just been protected by a European Patent (EP19382104.8; CARTs for the treatment of CD1a+ cancer). Our intellectual property rights coupled to our internationally-endorsed top-tier scientific publication are a major strength of our proof-of-principle demonstration that CD1a-directed CAR T-cells constitute a unique immunotherapy approach for coT-ALL. We propose to consolidate final technical-biological improvements and GMP-grade manufacturing of our CD1a-directed CAR T-cells in compliance with the requirements of the Spanish Regulatory Agency of Medicines and Medical Devices for advanced adoptive cellular therapies (AEMPS). Data from this project will be added to the final Investigational Medicinal Product Dossier (IMPD) of the CARCD1a T-cells to be submitted to AEMPS f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'DISRUPTIVE KESTERITES-BASED THIN FILM TECHNOLOGIES CUSTOMISED FOR CHALLENGING ARCHITECTURAL AND ACTIVE URBAN FURNITURE APPLICATIONS'.

assistant: **Innovation**

CUSTOM-ART aims at developing the next generation of building and product integrated photovoltaic modules (BIPV and PIVP respectively), based on earth-abundant and fully sustainable thin film technologies. Nowadays, BIPV and PIPV are identified as key enabling technologies to make “near Zero Energy Buildings” and “net Zero Energy Districts” more realistic, through the integration of a new generation of photovoltaic modules capable of entirely replacing architectural/mobility/urban-furniture passive elements. This promising scenario of mass realisation of BIPV and PIPV solutions can only be achieved by developing cost-efficient and sustainable thin film technologies with unbeatable aesthetic functionalities, including mechanical flexibility and optical tuneability. Unfortunately, mature materials already available at the market such as Cu(In,Ga)Se2 or CdTe are formed by scarce and expensive elements (In, Ga and Te), or toxic ones (Cd). Considering this, CUSTOM-ART will join for the first time a leading group of companies and academic partners all around Europe, to develop advanced BIPV and PIPV products (flexible and semi-transparent solar modules), based on earth abundant kesterite materials, which have been demonstrated in two previous European projects to be at the forefront of emerging inorganic thin film technologies. By combining advanced strategies for materials properties management, with customized modules design in a circular economy approach, two types of products will be developed including flexible PV modules (polymer and steel supports) and semi-transparent (polymer). CUSTOM-ART will bring these technologies from TRL4-5 up to TRL7, demonstrating very competitive conversion efficiencies (20% at cell and 16% at module level) and durability (over 35 years), at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Synthesis, mesomorphism and processability of oligomeric metal-containing liquid crystals'.

assistant: **Objectives**

Research objectives and content The liquid crystal group at the INFM research unit of Cosenza has successfully been developing strategies to incorporate transition metal centres into liquid-crystalline materials. Important results have be achieved in the synthesis of chiral and achiral low molecular mass complexes and ionic macrocyclic complexes. A natural extension of the work is to move to oligomeric or polymeric liquid-crystalling systems which can be regarded as a combination of the best aspects of metallomesogens and polymers. A strategy is proposed to synthesise new mesogenic metal complexes containing azo and/or hydroxyquinoline groups able to act as co-monomers in polycondensation reactions. The monomers will 1 reacted to obtain liquid-crystalline oligomers and the inclusion of photoluminescent metal centres will 1 contemplated. For many electronic applications, highly ordered thin layers are requested and therefore processability is an important requirement. In this respect, attempts to obtain thin films of these materials using the high vacuum deposition technique will be made. Training content (objective, benefit and expected impact) The proposed research is of importance in the development of the chemistry and technological applications of metal-containing liquid crystals and in the preparation of new materials with properties such as no linearity, photo refractivity and electroluminescence. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fulfilling the Law: Medieval Intellectuals and the Christian Making of Jewish Identity' (FULFIL) targeting Horizon 2020.

assistant: **Abstract**

Considering the cultural construction of minority identities in medieval Europe, FULFIL interrogates the impact of the Christian perceptions, conceptions and uses of the Hebrew Bible on the religious identification of Jews as a distinctive group. Given that Christianity was understood as fulfilling, not abolishing, the Old Law, how did the Jews’ purported misreading of their own sacred text affect ideas about their moral, social qualities? FULFIL’s objective is to investigate the intellectual forms, cultural processes and social effects of Christian ideas, as these emerged in a world with living Jews and Jewish practice.The close study of scholastic, narrative and iconographic sources in the Middle Ages aims to demonstrate that theological thought was not disconnected from common beliefs and representations. The first stage of the programme, at the interface between intellectual and doctrinal, religious, legal and social history, will consist of defining a coherent corpus of texts and images, and of critical editions of chosen texts. At the second stage, these documents will be analysed in order to set the contexts, identify the intellectual arguments, motives and metaphors, and evaluate their social effects. Incorporating the study of Jews and Judaism within the global history of Europe, FULFIL will help demonstrate and understand the constructedness of minority identities, as well as the social effects of intellectual labour. This makes it fully consistent with part 13 (« Europe in a changing world – inclusive, innovative and reflective societies ») and part 16 (« Science with and for society ») of the H2020 2016-2017 work programme. The gender dimension that it involves is related to the filiation between Christianity and Judaism and to the peculiar distribution of p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A complex systems approach towards REsilient and CONNECTED vulnerable European communities in times of change' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Europe is facing a number of global challenges such as digitalisation, migration, and climate change which increase demands on citizens’ resilience and puts them at risk of developing mental health problems. RECONNECTED responds to this problem by developing and testing a digital support system to promote resilience and connect vulnerable citizens in socially disadvantaged communities and evaluate whether this results in citizens’ improved mental health, increased mental health awareness, reduced stigma, and improved social participation, at affordable costs for implementation. Taking a complex systems approach, the project will first extend and test a recently developed theoretical integrative framework of urban mental health to include mental health responses to global transitions. This will provide a good understanding of how risk and protective factors at the individual, social, environmental, and societal levels interact dynamically and impact on mental health. The framework will provide actionable insights for policy decision making and will be used to develop a support system with intervention tools targeting individual and social levels simultaneously. The platform will be co-created with stakeholders in the local community in nine European countries. These interventions will be non-stigmatising and empowering and tailored to the needs of the local community. RECONNECTED will test the feasibility and effectiveness of the support system in these communities and, in the final stage, develop implementation scenarios that balance effectiveness with efficiency and scalability to inform policy decision making that can be used throughout Europe. The methodological approach in the project is theory-informed and data-driven, and we will use co-creation throughout the pro