RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unravelling the Mechanosensitivity of Actin Bundles in Filopodia' to be submitted under Horizon 2020.

assistant: **Abstract**

Eukaryotic cells constantly convert signals between biochemical energy and mechanical work to timely accomplish many key functions such as migration, division or development. Filopodia are essential finger-like structures that emerge at the cell front to orient the cell in response to its chemical and mechanical environment. Yet, the molecular interactions that make the filopodia mechanosensitive are not known. To tackle this challenge we propose unique biophysical in vitro and in vivo experiments of increasing complexity. Here we will focus on how the underlying actin filament bundle regulates filopodium growth and retraction cycles at the micrometer and seconds scales. These parallel actin filaments are mainly elongated at their barbed-end by formins and cross-linked by bundling proteins such as fascins.We aim to: 1) Elucidate how formin and fascin functions are regulated by mechanics at the single filament level. We will investigate how formin partners and competitors present in filopodia affect formin processivity; how fascin affinity for the side of filaments is modified by filament tension and formin presence at the barbed-end.2) Reconstitute filopodium-like actin bundles in vitro to understand how actin bundle size and fate are regulated down to the molecular scale. Using a unique experimental setup that combines microfluidics and optical tweezers, we will uncover for the first time actin bundles mechanosensitive capabilities, both in tension and compression.3) Decipher in vivo the mechanics of actin bundles in filopodia, using fascins and formins with integrated fluorescent tension sensors.This framework spanning from in vitro single filament to in vivo meso-scale actin networks will bring unprecedented insights into the role of actin bundles in filopodia mechan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular cloning and cytological analysis of cell polarity determinants controlling cell division in developing pollen' under Fourth Framework.

assistant: **Concept**

Research objectives and content In angiosperms, first pollen mitosis is a key event in the differentiation of the male gametophyte which determines the correct development of the sperm cells necessary for double fertilization, and therefore for plant fertility. Futhermore, this asymmetric division provides a rare opportunity to study the cellular and molecular basis for the establishment of cell polarity in plants. The laboratory directed by Dr. David Twell (Botany Department, University of Leicester, UK), has isolated a large number of Arabidopsis gametophytic mutants affected in cell division at first pollen mitosis. Six of these mutants show an alteration of the symmetry of microspore division: the microspore divides more symmetrically instead of asymmetrically. This symmetric division is followed by an incomplete or absent generative cell differentiation, indicating that this differentiation is critically dependent upon asymmetric cell division. The principal aims of the proposed work are to establish in detail the developmental profile of two of these Arabidopsis gametophytic mutants using cytological (confocal and electron microscopy) and genetic (crosses with mutant and transgenic lines) approaches (duration: 12 months), and to clone by transposon tagging the gene(s) responsible for these specific mutant phenotypes (duration: 24 months). Training content (objective, benefit and expected impact) The results may be of direct benefit in understanding fundamental developmental events in plants and animals which involve the establishment of cell polarity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Patient AI Treatment Hub' (PATH), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is one of Europe’s leading health burdens, responsible for 26% of all deaths in 2021, with mortality expected to rise by 24% by 2035 and an economic impact exceeding €100 billion annually. Despite the ambitions of Europe’s Beating Cancer Plan, integrating complex cancer data across systems remains a major obstacle. The European Health Data Space (EHDS) seeks to address these gaps, though challenges around interoperability, privacy, and infrastructure persist.In this context, PATH will transform cancer care by leveraging secure data exchange and digital technologies to improve early detection, diagnosis, treatment, and long-term patient outcomes. Through the integration of AI tools into clinical workflows, PATH will foster a safe, ethical, and sustainable healthcare ecosystem aligned with the Beating Cancer Plan and the EHDS. The project will create a federated, privacy-preserving health data space supporting interoperability and data fairness. AI models will be trained on representative, FAIR-compliant datasets with built-in transparency and bias mitigation. Federated learning and Trusted Execution Environments will enable secure, real-world model refinement while preserving patient privacy. An AI-powered dashboard will connect clinicians, patients, and developers to deploy validated tools and ensure broad adoption. To ensure long-term impact, PATH will conduct EU-wide pilot studies evaluating clinical outcomes, survivability, efficiency, and cost-effectiveness. It will also establish scalable business models, promote digital literacy among healthcare professionals, and drive cross-sector collaboration for responsible, evidence-based AI integration across Europe’s cancer care continuum.Delivering this level of clinical, technological, and systemic transformation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Emergence of Large Particles in Cluster-Cluster Aggregation' (AggregationKinetics).

assistant: **Innovation**

Cluster-cluster aggregation is a growth process mediated by collisions and subsequent irreversible coagulation events. Surprisingly diverse range of natural and industrial phenomena in physics (formation of rain droplets), astrophysics (star and galaxy formation) and chemistry (polymerization) are essentially driven by the same mechanism.  Therefore a sound understanding of these phenomena from theoretical and practical aspects is of utmost importance. We propose a multi-aspect study of dynamics of coagulating systems that undergo irreversible aggregation. The ambitious two-part project will encompass the mathematical analysis, physical derivations and numerical solutions of deterministic and stochastic aggregation models. The first part of the project will have the aim of addressing some of the important problems with regards to gelation, convergence to self-similarity and asymptotic behaviour of solutions of the Smoluchowski equation.  The second part of the project will be devoted to the modelling and analysis of large fluctuations in aggregating systems with a focus on generation of exceptionally large clusters where the mean-field description becomes inadequate. To address the latter problem, a theory for the statistics of large clusters within the framework of kinetic theory will be developed which involves derivation of new stochastic models at the particle or continuum level.Dr. Emre Esenturk did his undergraduate education in physics in Ankara. He obtained his MSc in physics and PhD in mathematics at University of Pittsburgh (2011). After this, he did postdoctoral research in the Brown University and Pohang University of Science and Technology. He has worked on a broad range of topics in mathematics and physics including modeling, analysis and computational asp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Crux Agribotics: The future of cucumbers harvesting - robot for automated agriculture labors' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

According to FAO, worldwide population is estimated to grow up to 8.3B people by 2030. Therefore, the world agriculture will be 70% processed by technology in order to address needs of food delivery. Crux Agribotics, project developed by our company Beltech B.V., was launched 8 years ago to promote automation in agriculture and increase crops (cucumbers) productivity. We already developed a prototype of the project with a Technology Readiness Level (TRL) 6, with the collaboration of the multinational Bayer. Crux Agribotics project is in touch with reality with direct contact with cucumber growers in The Netherlands, the official headquarters of Beltech B.V., who expressed their needs surrounding crops production process. Crux Agribotics technology value delivered through automated robot of cucumber harvesting that operates 24/7 and without human intervention, providing versatile solutions leading to: over 30% increase in crop yield, cucumber quality and homogeneity optimization, reduced use of pesticides up to 90% following the European Directive 2009/128/EC and 70% reduced infection risks. This way, growers will focus on their core business and handling supported by real-time data collected by the system. In a future view, we intend to develop an integral Handling System of crops production featuring also the implementation of the following functionalities: transportation, packaging, data mining and precision farming. Crux Agribotics will disrupt the way cucumbers are grown and how greenhouses will be equipped in the future. Its success is ultimately based upon a win-win proposition for the entire value chain and all stakeholders, from consumers, retailers and growers. Crux Agribotics disruption will enable an addressable market of high-tech greenhouses and high-wire c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Pro-active decision support for data-intensive environments'.

assistant: **Concept**

ASTUTE aims at defining reference architecture for the development of HMIs, targeting proactive information retrieval and delivery based on situational context, as well influenced by information content and services, and user state information. This architecture will support the user intentions, optimizing the choices available to the user, while keeping the user in control of the situation. Verified by demonstrators, the architecture will allow for multiple instantiations for different domains such as avionics, automotive and emergency management.The ultimate goal is to develop a platform for building embedded products that capture and act upon user intentions thereby taking into account the user’s context (i.e. user environment and all the factors which will influence the user performance) and state (i.e. aspects determining the ability of the user to perform in a given situation). The challenge is to seamlessly access relevant multimodal information in a context-sensitive way.  For instance, in the aviation domain, this architecture will be used in novel design of the flight deck alerting and notification system. Pilots will receive alerts and notifications via a multimodal interface which selects the appropriate modality on the basis of the context and the user state. In the automotive domain, the system will integrate information from various sources (camera, physiological parameters, etc.) to proactively present decision support information, at the right level of detail according to the context, by discarding annoying or distracting low level information.The ASTUTE approach will be validated with demonstrators proposed by large industrial organizations (Honeywell, BMW, ST-Italy, Akhela, Luciad): 1) Smart embedded alert and notification system for flight deck (avio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Prediction of AF incidence using PR interval measurements, echocardiographic data and biomarker profiles:  Analyses within epidemiological Framingham Heart  Study and LIFE Health Care Study cohorts' in the context of a Horizon 2020 call.

assistant: **Objectives**

Atrial fibrillation (AF) may be categorized as an epidemic disease associated with an increased risk for heart failure, thromboembolism, dementia and mortality. The underlying mechanisms behind AF describe multiple pathological states leading to various remodeling processes. One of the easiest available diagnostical tools is an electrocardiogram (ECG). Numerous P wave indices have been identified, demonstrating associations with increased risk for adverse cardiovascular outcomes and mortality. Prolonged signal-averaged P wave duration (SAPWD) measured from the non-invasive signal averaged electrocardiogram (SAECG) using a vector composite of filtered orthogonal leads accurately measures cardiac activation times. In comparison with analysis of a standard 12-lead ECG, the SAECG is superior in detection of P wave prolongation as a risk marker for AF. However, there are only limited data analyzing this issue.Current project is aimed to perform P wave SAECGs in Framingham Heart Study (Boston, US) and LIFE Health Care Study (Leipzig, Germany) and to investigate their role in AF incidence. Furthermore, estimation of corresponding lifetime risk will be performed using multistate modeling phenomapping of AF, e.g. classification of AF patients based on a broad range of data (clinical, laboratory, ECG, echocardiography, biomarkers) predicting adverse clinical outcomes.The current project represents an innovative and authentic multidisciplinary research in AF and includes different future perspectives. It paves the way for fruitful international cooperation with Framingham cohort - the one the most renowned epidemiological studies, intensive exchange of experience and researcher mobility as well as academical and practical implementation of cardiovascular epidemiology and preventio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Psychosocial fActors Relevant to BrAin DISorders in Europe'.

assistant: **Innovation**

The overall prevalence of brain disorders – both neurological and psychiatric – is very high in Europe. Although it is well known that the burden and costs of these disorders are high, there is evidence that the overall, personal, social and economic costs of brain disorders have been underestimated because of the lack of valid and reliable information regarding the full range of psychosocial difficulties that actually shape the lived experience of persons with these disorders and affect their quality of life. Current European data on psychosocial difficulties are derived from the diagnostic criteria of each disorder and so take the form of narrow ‘information silos’ that are neither comprehensive nor comparable across disorders. Distinct information silos means that treatment planning, treatment evaluation and outcome assessment ignores commonalities of psychosocial consequences across disorders, undermining treatment efficiency and effectiveness, and ultimately increasing the costs of health and social care provision. The coordination action called PARADISE has the general objective of coordinating the development of a comprehensive and cross-cutting or ‘horizontal epidemiology’ of psychosocial difficulties associated with brain disorders. Since a horizontal epidemiology accounts for the psychosocial difficulties that are actually experienced by people with brain disorders, independently of the brain disorder associated with them, it concentrates on what is more relevant to the lives of people with brain disorders. This leads to more effective intervention planning and management, and therefore to improved quality of life along the continuum of care, in the community, and across the life span. PARADISE coordinates the existing expertise in partners from eight European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'SME - Intelligence Network for Co-operation in E-Health Roadmapping Events and projects'.

assistant: **Innovation**

e-Health is one of the priority areas in the European Union and is of paramount importance from several aspects; better healthcare for citizens, easier access to care regardless of EU state, coordinated systems within the health sector etc. Action Plans have been put forward from the Commission as well as from national levels.The challenge will be to coordinate these action plans and strategies aimed at increasing research and strengthening competition and growth at EU level. The proposed consortium within SINCERE is planning to operate in Sweden, Germany, the United Kingdom, Italy, Latvia, Norway and Turkey. The countries have reached different levels of development in the e-Health area, which will contribute to achieving synergy effects.Our target is to have 150 actively involved SMEs of which around 100 will publish their partnering profiles on various databases, and for at least 20 per cent of them to form partnerships. They will receive knowledge and training in how to participate in FP projects and on how to roadmap technologies and innovation. Throughout the SINCERE-project, the SMEs will be given support and assistance in both partnering and project cooperation.The set targets and objectives focus almost exclusively on increasing competence, knowledge and activities among SMEs in developing technology roadmaps and FP-project participation. These components will be provided mainly through regional workshops and training seminars. As internationalisation is a vital link in improving the employment situation, through encouraging investments and thus stimulating growth, a transnational conference in e-Health will be held in the second year, in combination with workshops.The consortium will carry out 185 innovation audits, in order to engage the appropriate participa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DISmantling and RECycling Techniques for road MATerials - Sharing knowledge and practices' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The DIREC_MAT project objective is to share, at a European scale, knowledge and practices on recycling road and road-related waste in the aim of ensuring an environmentally-friendly and sustainable end-of-life for road infrastructure. Road material recycling processes have previously been studied in national and European research projects and have led to various levels of practical implementation; unfortunately, the national experiences developed across Europe almost never benefit other European countries. This is especially true for the newer Member States. Furthermore existing knowledge and practices are presently scattered. Reliable practice-oriented data on all types of road materials and waste will be identified and compiled by skilled experts working in both research and construction capacities. Field experience and relevant research issues will be integrated into a Web database to provide the European road community with unrestricted access to updated online data on end products that have been classified, assessed and illustrated with jobsite practices for dismantling and recycling applications. This database will not only offer information to stakeholders on facilitating the correct re-use of road and road-related waste products back into roads without generating health impacts, but will also provide technical and scientific information for CEN Technical Committees. Lastly, such a tool will make it possible to better identify outstanding research needs in this area. Best practice guides on green techniques for recycling road and road-related waste back into roads will be delivered; benchmarking processes will be detailed and shared by all stakeholders in order to achieve a road material recyclability level of nearly 100%. FEHRL (Forum of European Highway Researc