RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biopolymers 13C tracking during fast pyrolysis of biomass-A 2-level mechanistic investigation' (PYROCHEM).

assistant: **Concept**

The Marie Skłodowska-Curie Actions (MCSA) proposal is the opportunity for Dr. Marion Carrier to reach a new level of understanding of fast pyrolysis mechanisms and improve the process and design of reactors by acquiring the necessary knowledge at a molecular-level and training using fractionation and isotopic characterization techniques, practical experience on micro-reactors and on larger scale laboratory reactors. It is proposed to use an integrated experimental and computational approach to provide molecular-level insights into pyrolysis chemistry by following the fate of 13C labelled lignocellulosic biopolymers, and subsequently to elucidate the main chemical events during the conversion of biomass. Empirical and mechanistic models will be combined to suggest a new kinetic model of fast pyrolysis. The thermal behaviour of individual unlabelled and labelled biopolymer carefully extracted will be investigated under controlled kinetic regime. The delineation and quantification of primary and secondary reactions will be achieved via the development of new devices for the collection of organic volatiles and via the implementation of spectrophotometric and spectrometric methods. For this, a combination of strong interdisciplinary expertise in several fields such as biopolymer chemistry, thermochemistry, aerosols trapping device fabrication, characterization of gas, liquid and solid products using spectrophotometric and spectrometry techniques is required. This multidisciplinary project will facilitate the commercialization of emergent renewable energy technologies such as fast pyrolysis via the optimization of bio-oil yields and quality, which is expected to offer alternative solutions in the co-production of fuels, high-value-added chemicals and energy, the main research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Study of the adhesive interaction between human and pig cells via daf/cd97. significance in xenotransplantation'.

assistant: **Concept**

In xenotransplantation, adhesion of pig-to-human cells may play an important role in the rejection of porcine xenograft issues. Human decay accelerating factor (DAF or CD55) is an important regulator of the complement activation. Transgenic pigs expressing human DAF are being bred in the expectation that organs from these pigs will be better protected from hyperacute rejection, a consequence of the activation of complement. Recently, DAF have been identified as a high affinity ligand for the CD97 molecule, which is expressed upon activation of many !eucocytes. Hence, expression of DAF in pig organs, although abrogating hyperacute rejection, might theoretically predispose to develop.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of an advanced rotor for tilt-rotor' in the context of a Fifth Framework call.

assistant: **Objectives**

The proposal addresses the development of a full-scale rotor suited to an advanced European tilt-rotor configuration. This is a challenging issue because such a rotor must be capable of providing all the tilt-rotor required controls, accepting the various loads, in particular those brought about by the tilting movements, producing good performance data and taking account other constraints: low external noise, comfort, affordability, reliability and safety.The aim of project DART is to tackle this important problem and to prepare a future European tilt-rotor consistent with the market requirements by:- Reducing the risk related to its rotor development.- Gaining a better understanding of the technological issues associated with tilt-rotor rotor hub and blades design.- Bringing significant improvements compared to actual helicopters or turboprop aircraft, especially in term of performance data, external noise, vibration level, safety and affordability standards.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Flat Display Interface for Information System' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The objective of this best practice action is to use flat displays first time by Skyvision in screen based information systems by developing a digital MPEG2 based video distribution system, which enables real-time and high quality transfer of computer generated pictures to flat displays.The new information system consists of MPEG2 Encoder unit beside PC and MPEG2 Decoder units beside flat displays. Standard, inexpensive and thin twisted pair cables can be employed with MPEG2.It will make possible to transfer video signal in the new information system in a digital form at all steps:PC -> encoder unit ->line connection -> decoder unit -> flat display.The new digital display connector (DVI) specially designed for flat panels will be utilised in this project.The paypack period of this project is under 3 years and Profitability Index is over 300%.Objectives:Technological objectives is to use flat displays first time in screen based information systems by developing a digital MPEG2 based video distribution system, which enables real-time and high quality transfer of computer generated pictures to flat displays. A new Digital Visual Interface (DVI) connection will be utilised. The goal is to transfer video signal in a digital form in all steps.Business Objectives: This Best Practice Action with potential patent will have a great strategic impact on Skyvision's position in information system market and it will essentially improve the competitive edge of Skyvision. The goal after project is to become a technology and market leader as a component supplier for information systems. Payback period of the project is under 3 years and Profitability Index (PI) is over 300%.Work description:This project includes the design of MPEG2 encoder and decoder units, which enables the optimal co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Realising the economic potential of renewable resources - bioproducts from non-food crops'.

assistant: **Concept**

For rational decision-making, national and EU policy-makers need reliable, information indicating the best ways to achieve optimal societal benefits and realise the economic potential of the cultivation and use of non-food crops. In spite of extensive EU supported RTD activity over two decades few new crops are grown and only a limited number of products are marketed. To reach the European agricultural, industrial and market potential requires an integrated analysis of technical and non-technical barriers facing non-food applications so that further RTD effort is not wasted, but is focused on those areas with a high possibility of success, with social, economic and environmental benefits and contributing to mitigation of greenhouse gases. This will be achieved through a full analysis of the growing knowledge-base in this area by a consortium of 12 Partners and an Advisory Group of 45 experts from the EU, US and beyond, with representatives in universities, research institutes, international and governmental agencies, SMEs and large multinational companies. The integrated multidisciplinary analysis will review scientific and technical challenges in the context of societal expectations and economic, environmental, legislative and regulatory parameters. It will result in recommendations of key activities (Flagship Programmes) that are most likely to result in development of products/ applications that can be developed from agriculture and forestry and provide tangible societal benefit by 2020. EPOBIO will also define good practice for communication (based on the advice of experts, stakeholders and policy-makers in Workshops) and disseminate this via the media and a dedicated website, to increase public awareness and understanding of this potential as well as providing guid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Re-defining clinical care and reasoning in ST-elevation myocardial infarction (STEMI) by shifting focus to ischemic myocardial stunning - Mechanisms prognostic implications and a new treatment', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Acute ischemic heart failure (AIHF) after ST-elevation myocardial infarction (STEMI) is a common and life-threatening condition for which the prognosis has not improved over the past decade, and for which no effective treatment option exists. Women, who have been underrepresented in most STEMI studies are more likely than men to develop AIHF after STEMI. My research aims to shift focus from traditional treatment targets (increased cardiac work and maintenance of blood pressure) to manipulation of myocardial stunning, the physiological phenomenon in which viable myocardium suddenly lose its function (becomes ‘stunned’) when exposed to a stressor (e.g. ischemia). Specifically, I aim to: 1) compare how stunning and propensity for AIHF affect prognosis for women vs. men with STEMI – using causal mediation analysis applied to a unique nationwide STEMI cohort (around 40,000 patients); 2) prospectively compare the rate of stunning resolution in STEMI patients with vs. without microvascular obstruction, in patients with STEMI vs. patients with takotsubo (another form of myocardial stunning with more favorable prognosis), and for women with STEMI vs. men with STEMI; 3) conduct a randomized controlled trial to assess the optimal timing of initiation of guideline-directed heart failure medications after STEMI; and 4) determine if pre-existing takotsubo-like stunning is protective in experimental AIHF. If my main hypothesis is correct, my this project could change the way researchers and clinicians approach the pathophysiology and treatment in STEMI. Irrespective of whether my main hypothesis is correct, my research proposal is designed to provide important insight into the pathophysiology and prognosis of myocardial stunning in STEMI, with a clear sex perspective that can help mit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanical Integrity for Advance Transmission Systems' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives and content Objectives and content This Brite Euram RTD Industrial Research Proposal addresses task 3A.3.13 of the IMT workprogramme. It has the aim to deliver an integrated package of work to meet today's and the future needs of the mechanical prime mover and power transmission industries. The target objectives for the programme are to develop design rules, new component and analytical methods by experimental and theoretical means. This will improve the fundamental understanding of the interrelationships between individual transmission components; such as: oily chamber sealing, oil churning and oil fires in bearing chambers, gear lubrication, and two-phase flow separation. By doing so it is anticipated that product safety, reliability, and efficiency can be increased, whilst reducing the impact on the environment. The work will be implemented by 13 partners, from 4 countries; France, United Kingdom, Germany and Belgium, who have been drawn from the aero engine gas turbine, helicopter, and component supply industries, and four universities. To ensure effective consortium management the workprogramme has been divided into 4 workpackages, namely: Workpackage A The development and evaluation of lift augmented seal designs Workpackage B The design of two-phase air/oil flow separators and breathers Workpackage C The understanding of the fundamentals of vent pipe two phase flow, heat-to-oil in bearing chambers, film dynamic, and oil fires Workpackage D Gear lubrication, cooling and power loss. The approach taken by the consortium will be one of an integrated programme, where results from one workpackage will be fed into another, through its management structure. The driver for the proposal has been taken from the industrial partners requirements to be more competit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Regulation and outcome of immune cell interactions in vivo'.

assistant: **Concept**

The immune system is made up of specialized cells and tissues that act together to fight microbial infections and survey the body for malignant transformation. Immune responses are highly orchestrated and dynamic events that largely rely on the ability of immune cells to migrate in organs and tissues, to interact with each other in order to exchange information and to engage target cells in tissues to fulfill their effector functions. Natural killer and T lymphocytes are two key players of the host responses to pathogens and to some tumors and belong to the innate and adaptive arm of the immune system, respectively. The formation of cell-cell contacts represents a key event for T cell and NK cell to receive activation signal and exert effector functions. Ultimately, the efficiency of immune responses is critically dependent on the regulation and outcome of these contacts. We aim to launch a new generation of intravital microscopy that will allow us to move beyond the descriptive and towards functional imaging studies so we can get the ability to analyze, not only cellular behaviors, but also the signals and outcome of interactions established by T cells and NK cells in vivo. We will link key parameters regulating contact formation during T cell activation by dendritic cells, including calcium elevation, immunological synapse formation and contact stability in order to determine how they act together to influence T cell fate. In addition, we will further develop our projects on disease pathogenesis with the aim of gaining new knowledge on tumor immunity and parasitic infections. Identifying the parameters that regulate lymphocyte contact formation and outcome in these contexts will undoubtedly help delineate basic principles to improve strategies to treat cancer and infe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'International Conference on Research Infrastructures (ICRI 2016)' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The next International Conference on Research Infrastructures, (ICRI), will be hosted in South Africa in October 2016.  The Department of Science and Technology (DST) will be co-hosting ICRI 2016 with the European Commission (EC).  In the recent few years, ICRI has become the platform for stakeholders to engage and interact on many of the critical research infrastructure (RI) related questions.  ICRI 2016 will be an international event bringing together experts from across the globe and also seeking to make recommendations going forward for the RI community.  It will bring together a set of speakers that are representative of the global debate on RI as well as target participation from across the world.  The Conference will target multiple stakeholders including scientists, RI managers, multilateral institutions, policy makers, politicians, foundations as well as the private sector.  The conference aims to attract 600-700 participants from across the globe. ICRI 2016 contributes to the general objectives stipulated in the European Commission’s work programme “European research infrastructures (including e-Infrastructures). The work programme highlights the role of RI within the context of the challenges that are faced globally.  The themes of ICRI will be developed in a manner that also stimulates dialogue on the critical role that RI plays in addressing socio-economic challenges. The objectives will be to host a successful International Conference on Research Infrastructures (ICRI).  The project will enable the successful organisation and implementation of the Conference, through key focus on project management; communication and branding; and logistics and organization.  The Conference program will consist of a high level plenary, thematic discussions and exhibitions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nanotherapeutics for antibiotic resistant emerging bacterial pathogens' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Increase in antibiotic resistance is a global concern worldwide. The project NAREB's main objective is the optimization of several nanoformulations of antibacterial therapeutics in order to improve the therapy of multi-drug resistant (MDR) tuberculosis (TB) and MRSA infections in European MDR patients.NAREB will address the problem of drug bioavailability inside the infected macrophages, transport across the bacterial cell wall, and avoidance of escape mechanisms (expressed by the pathogen). The success of the utilization of nanoparticles in the improvement of drug targeting in other diseases opens the way for novel applications in nanotechnology-based treatments aimed at controlling MDR-TB and MRSA.Specific objectives to achieve the main goal are:(i) Screening of different combinations of antibiotic drugs (small chemical molecules and/or biomacromolecules - glycopeptides) with nanocarriers (lipid, polymeric, biopolymeric);(ii) Loading of Transcription Factor Decoys (TFDs) designed to block the expression of essential bacterial genes in compatible nanoparticle systems and their testing as novel antibacterials;(iii) In vitro and in vivo testing of the best therapeutic combinations in relevant experimental models and using innovative bioimaging;(iv) Improved formulations of multifunctional particles containing selected antibiotics and TFDs for increasing the bioavailability of active molecules in the site of infection (targeting strategy, adapted route of administration)(v) Assessing safety, regulatory and production (GLP/GMP) aspects in relation with the most promising nanoformulations;(vi) Clinical Development Plan for the preparatory work for the subsequent clinical testing of the selected nanoformulations.The project NAREB brings together 15 partners (including 4 SMEs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '“Quantitative analysis of the molecular and cellular behaviors associated with cardiac valve morphogenesis in pathological and regenerative contexts”' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cardiovascular diseases (CVDs) take a huge toll on the world population. An estimated 19 million people died from CVDs in 2010, representing 30% of all global deaths. Abnormal blood circulation is widely recognized as a cardiovascular risk factor and mechanotransduction has been shown to trigger pathologies such as atherosclerosis1, cardiomyopathies2 and valvulopathies3. Mechanotransduction is the conversion of a mechanical stimulus into a biological response. It is central to the coordination between mechanical forces generated by flowing blood and heart valve morphogenesis. In the developing heart, the heartbeat and the blood flow signal to endocardial cell (EdC) progenitors through mechanosensitive proteins which in turn modulate the genetic program controlling cardiogenesis4. It is essential to determine how mechanical forces control pathway activation and morphogenesis in vivo because the mechanical stimuli experienced by EdCs are too complex to be faithfully reproduced in vitro.  This timely proposal aims to uncover the cellular molecular programs activated in EdCs in response to mechanical forces during normal heart valve development and address their potential function in valve regeneration. My hypothesis is that endocardial mechanotransduction and mechanical forces are not only key for the morphogenesis of the valve, but also for their maintenance and repair. Specifically I aim to investigate the spatial and temporal nature of endocardial cellular behaviors necessary for cardiac valve morphogenesis in normal, pathological and regenerative contexts.