RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Building confidence in deep disposal : the borehole injection sites at tomsk-7 and krasnoyarsk-26' in the context of a Fifth Framework call.

assistant: **Objectives**

BORIS will use data and samples from the Russian deep borehole injection sites for liquid radioactive waste at Tomsk-7 and/or Krasnoyarsk-26 to further understanding of the chemical behaviour and migration of radionuclides in the geological environment, and thereby build scientific and societal confidence in radioactive waste disposal safety assessments and the deep disposal concept. At the Russian sites, it is possible to study radionuclide geochemical behaviour at similar depths to those envisaged for a deep geological repository for radioactive wastes. Models of radionuclide solubility, speciation and transport over a wide range of pH and Eh will be tested and corroborated. BORIS will demonstrate the ability of Western PA models to assess a real-world" example of radionuclide migration in the deep geological environment, and will evaluate the extent to which the new data can be used to build confidence in geosphere performance.BORIS Phase I made use of the unique dataset available at the Russian sites describing the environmental behaviour of a wide range of radionuclides, developed a sampling strategy for rock and water samples, and documented the relevance of the sites for Western repository PA studies. Information collected at the borehole injection sites over the last 30 years, including data describing the injection process, inventory, and migration of the waste component within the reservoir horizons has been compiled into an electronic database and analysed. New water samples were obtained from existing monitoring and test boreholes. Contaminated samples were examined in Russian laboratories, and preliminary geochemical investigations of samples were made, including radioanalysis, trace and major element analysis and colloid quantification. Filtered groundwate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Gliders for Research, Ocean Observation and Management' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Underwater gliders are intelligent and affordable platforms, useful for long-term, multi parameter marine observations. Because of their remotely controlled navigational capabilities and the high spatial and temporal resolution of their measurements in  real-time, gliders have been identified to fill gaps existing in the existing ocean observing systems. Along with there rapidly growing importance in purely science driven applications, the implementation of gliders into the Global Ocean Observing System has been recognized as a key point to improve the observational capabilities of the observing systems.The objective of the GROOM proposal is the design of a new European research infrastructure to use underwater gliders for the benefit of European citizens, researcher, and industry. GROOM will define the scientific, technological and organizational/legal levels, of a European glider capacity for research and sustained observations of the oceans, in line with the other European and international initiatives for marine in-situ observations. The proposal for this new infrastructure strongly relies on EuroARGO and JERICO infrastructures which are emerging  and also considers the relevant international coordinating bodies such as GOOS. The proposed technological infrastructures will be based on several dedicated  'gliderports' to maintain and operate a European fleet of gliders in coordination with US, Canadian, Australian and other similar infrastructures. This new infrastructure would be beneficial for both academic oceanographic research and operational oceanography systems on which a large number of marine activities and societal applications now rely.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Harmonic generation in plasma optical waveguide' (1994-1998) under Fourth Framework.

assistant: **Objectives**

We propose to generate of ultrashort laser pulse harmonic radiation in a plasma optical waveguide generated by a preceeding laser pulse. The key idea is to increase the interaction length. We expect a good conversion efficiency since phase matching can be achieved in the plasma waveguide even in the presence of free electrons. We plan to create optical channels by sending a first laser pulse on lithium atoms, singly ionizing them. A second pulse is injected in the formed channel in order to produce high order harmonics. We hope to extend the harmonic spectrum to unprecedently short wavelengths of coherent radiation than al- ready observed, due to the high intensity that can be tolerated by Li+.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Energetics and physiology of a diving bird; the use of heart rate to estimate field metabolism of king penguins' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content King penguins are one of the top predators in the marine ecosystem and represent a significant proportion of the avian biomass of the Antarctic region. To obtain food for their chicks, they forage some 300-1000 km away from their breeding sites and dive to depths of up to 300 m and for as long as 7.5 minutes. The physiological adaptation required to perform such outstanding behaviour are not fully understood. Data logging equipment and technique recently developed at Birmingham University enable depth, body temperature and heart rate to be obtain from free ranging aquatic birds. Heart rate is used to give an estimate of energy expenditure during the various types of behaviour. Such knowledge of activity-specific energy budgets and physiological data are essential for the construction of more accurate models for management of the marine resources in the Antarctic and sub-Antarctic areas, in addition to explaining why penguins are such accomplished divers. Training content (objective, benefit and expected impact) By working at Birmingham, I will be trained to use the most recent data logging equipment available for the study of the energetics and physiology of animals in their natural environment. In addition, I will be trained to analyse the complex data sets collected by the data loggers and in relating these to the behaviour of the animals (foraging, fasting, incubation, chick rearing) and the hostile environment in which they live. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '100 Gb/s Optical RAM on-chip:\nSilicon-based, integrated Optical RAM enabling High-Speed Applications in Computing and Communications' (RAMPLAS).

assistant: **Innovation**

For over two decades ICT witnesses the steadily increasing gap between processor and memory speed. RAM is too slow to keep up with processor speeds, creating a bottleneck in system performance. To address this, RAMPLAS will revisit RAM fundamentals and will lay the foundations for optical RAM technology and for optical RAM-enabled green and ultra-fast computing architectures. RAMPLAS will develop the first 100GHz optical RAM chips and will foster a new framework of disciplines for its effective application in ICT.RAMPLAS cross-disciplinary workplan blends innovation in computer science, optical design, photonic integration and semicondictor physics. It aims to provide the theoretical foundations of optical RAM and to introduce novel optical RAM circuit designs. A building block approach will associate circuit design with physical layer parameters. Novel epitaxial methods will be employed for the fabrication of ultrafast dilute-nitride-antimonide gain regions on GaAs (InGaAsNSb/GaAs) towards the deployment of active elements for 100GHz optical RAM. Heterointegration techniques will increase integration density on established SOI technology. Multi-bit RAM chips with up to 64-bit capacity are envisaged to pave the way to densely integrated optical RAMs and kByte capacities.RAMPLAS holistic approach addresses the entire framework for optical RAM-enabled computing. Fundamental connections between Content Distributed Networks and CMP architectures will be established to introduce the concepts of distributed optical cache. New 3D cache mapping algorithms will be researched, exploiting the wavelength dimension in memory addressing for Reconfigurable Set-Associative cache mapping towards maximizing cache hit ratio. The research outcomes of RAMPLAS will be evaluated in a solid pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Translational optoelectronic control of cardiac rhythm in atrial fibrillation' (TransRhythm).

assistant: **Innovation**

It’s my conviction that, one day, we will enable the human heart to terminate its own rhythm disturbances and thereby restore its normal rhythm at any place and time. Such acute restoration of cardiac rhythm would not be based on traumatizing electric shocks, but on generation of bioelectricity by the affected heart itself. In order to explore this paradigm-changing approach for ambulatory shock-free control of cardiac rhythm, I will integrate the unique advances of genetic engineering, computer modelling, tissue engineering and micro-optoelectronics. To determine the advanced and translational potential of such optoelectronic heart rhythm control, the most prevalent cardiac arrhythmia will be targeted, atrial fibrillation (AF).To this purpose, we will first engineer human atrium-sized 3D models of AF from fully functional conditionally immortalized human atrial cardiomyocytes expressing light-gated ion channels. To realize and explore optoelectronic rhythm control in these models, customized multi-electrode-LED arrays (MELAs) will be integrated to gain full control over bioelectricity generation by precisely tailored illumination. Such illumination will be accomplished by a modular interactive optoelectronic system allowing continuous, accurate and realtime monitoring-based activation of specific LEDs in the MELAs. Insights from these studies will guide the application of this approach in pig models of AF to determine its feasibility, safety and therapeutic implications. From design to interpretation, all these studies will be supported by advanced computer simulations to realize an iterative process of optimization for maximum project outcome.Establishing translational optoelectronic control of cardiac rhythm is expected to break new ground by revealing unique novel i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Membrane fusion mediated dermal allergy immunotherapy'.

assistant: **Concept**

In this project we aim to develop a new delivery platform for allergy vaccines with a high efficacy and a high safety profile combining membrane fusion-mediated delivery and microneedle-based dermal delivery.Background: Within the ERC Starting Grant “Direct Drug Delivery”, I developed a method for the controlled fusion of liposomes with cells. A set of complementary peptide amphiphiles (coilK and coilE), able to form heterodimeric coiled coils, were shown to induce targeted and efficient fusion between two opposing membranes. More importantly, we have shown that this method of fusion can be applied to liposomes and to live cells. Since liposomes can be used as drug or vaccine carriers, this enables the direct delivery of these compounds into live cells. The Problem: Allergen-specific immunotherapy for treating allergies such as asthma is currently performed via chronic subcutaneous administration of allergen extracts to patients. Unfortunately, it requires monthly injections for several years to achieve the desired long-lasting immunological tolerance. These vaccinations are typically performed by intramuscular or subcutaneous injections, causing pain and stress. Therefore there is a need for a new and more efficient administration platform to achieve shorter, safer and more patient-friendly protocols.Our solution: Dermal delivery of vaccines offers a great potential, due to the large number of immune cells present in the skin. In order to increase the efficacy of current allergen-specific immunotherapy, it is our idea to use the membrane fusion heterodimeric coiled coil peptide pair to induce efficient cellular uptake and processing of a commercially used allergen (rBet v1) encapsulated in liposomes in order to increase its efficacy as an allergy vaccine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Probabilistic and sensitivity of crack assessment in high temperature plant and applicability of hida procedure' to be submitted under Fifth Framework.

assistant: **Abstract**

This proposal aims to incorporate appropriate probabilistic assessment methodologies in to the European high temperature crack assessment procedure 'HIDA'. The work involves carrying out sensitivity analysis and probabilistic assessment of the large data base of the HIDA Databank (which forms a part of the HIDA Knowledge Base System (KBS)) and re-organising the data in a suitable format. This will be done so that the HIDA Procedure and the HIDA-KBS can be used by high temperature industry (such as petrochemcial, nuclear, power plant or waste incineration) for life and safety assessment of components containing design allowable or service induced crack like defects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'On-the-fly nonadiabatic quantum dynamics suitable for large biomolecules:Developing the DD-vMCG method' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Nonadiabatic effects play an important role in many molecular systems, including those of biological relevance. Processes such as photosynthesis, photoreception and bioluminescence are initiated by photoexcitation followed by the evolution of the system with splitting of the nuclearwavepacket in the manifold of electronic states. Nonadiabatic quantum dynamics is a method of choice to study these processes theoretically as the Born-Oppenheimer approximation fails inthe regions where electronic and nuclear motions are coupled. The usual approach involves a preliminary calculation of the potential energy surface of the system, which becomes unfeasible with the increase of dimensionality. In order to treat many-atomic systems a direct dynamics variational multi-configuration Gaussian wavepacket (DD-vMCG) method has been developed. It enables on-the-fly potential energy evaluation due to the usage of localized Gaussian functions as a basis set while retaining the full quantum character of the nuclear wavepacket. The method still has a field for improvement, especially with respect to the algorithm of diabatisation as only an approximate version of this is currently implemented. In the current project we therefore aim atupgrading the DD-vMCG method and further applying it to biological systems in which nonadiabatic effects play a role (e.g. the green fluorescent protein). In order to study big systems we plan to use a hybrid quantum mechanical/molecular mechanical approach that allows us to treat the most important part of the system at the quantum mechanical level, while the remainder is treated with less accurate, but much faster classical mechanical methods. We thus will open the doors for the accurate quantum dynamical investigations of biological systems, that were only
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Gen Duplication and Amplification in Staphylococcal populations'.

assistant: **Concept**

Bacterial pathogens possess the ability to adapt rapidly to changing environmental conditions which is especially apparent in the hospital setting where bacteria acquire antibiotic resistances readily. Besides well studied mechanisms such as horizontal gene transfer bacteria can alter the genetic material by acquiring gen duplications and amplifications (GDA). Exemplarily an improved gene dosage of a minor resistance determinant can lead to increased resistance to antibiotics. Due to the difficulties in their detection GDAs are almost exclusively studied in model organisms and neglected in natural populations of clinically relevant species such as Staphylococcus aureus. Accordingly many important questions about the frequency and clinical importance of GDAs remain unanswered. State of the art sequencing technologies enable the identification of GDAs by analysis of the coverage scaffold and groundbreaking experiments using 387 USA300 genome sequences showed promising results regarding putative copy number variation of virulence factors. We will extend the GDA analysis to ca. 1200 already available EMRSA15 sequences. This will enable a comprising analysis of gen copy number variation in clinical isolates and might allow identifying genomic regions under strong evolutionary pressure during infection. We will optimize experimental setups for the rapid validation of GDAs by qPCR and develop techniques to study the effects of GDAs in S. aureus. Furthermore we will sequence a selection ca. 70 S. aureus isolates causing chronic infections in patients suffering from cystic fibrosis (CF). This will enable us to optimize the detection of GDAs by NGS and will allow investigating the role of GDAs during adaption to the complex environment within the CF-lung. This project will show n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced gene therapy tools for treatment of CNS-specific disorders' (NEUGENE).

assistant: **Concept**

Curative therapies still do not exist for most CNS diseases but gene therapy is a promising new approach. We propose that it will be possible to modify brain function and pathophysiology by targeted delivery of specific curative factors to selected populations of brain cells that are affected by disease. This opens the door for effective treatment regimes, which can be tailored to individual patients needs. However, currently available gene transfer vectors have limitations regarding safety and efficacy, as they do not allow for targeting of specific populations of neurons or glia or regulation of transgene expression.  The NEUGENE consortium has been founded by leading European scientists from academia and industry to overcome these limitations. The consortium will develop Adeno-associated virus (AAV) and Lentivirus (LV)- based tools for targeted and regulated gene transfer into different populations of CNS cells. The consortium will provide a selection of vectors that are optimized for different therapeutic approaches, e.g. regulated expression of neurotrophic factors or manipulation of neurotransmitter synthesis in specific neurons. NEUGENE has three major goals:1) targeting gene transfer vectors to specific populations of neurons and glia, by transcriptional regulation and miRNA-mediated de-targeting and by exploiting the cell-specific tropism of novel types of viral vectors, 2) tight control over expression levels of therapeutic genes by using regulated systems based on different principles, and 3) establishing the safety of the novel vector tools.  NEUGENE will verify the functional efficacy of the novel CNS gene transfer tools in a well-established animal model of Parkinson's Disease (PD). This disorder affects over 1.000.000 Europeans and is increasing in preval