RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Consortium for Products across Europe in Duchenne Muscular Dystrophy' under Seventh Framework.

assistant: **Concept**

This project builds on results from the TREAT-NMD and BIO-NMD European projects to develop a personalised-medicinal product through to market for the treatment of Duchenne Muscular Dystrophy (DMD). DMD is an inheritable, childhood rare disease that affects approximately 1 in 3,500 newborn boys. This rare disease is caused by mutations in the dystrophin gene, resulting in the absence or defect of the dystrophin protein. As a result, patients suffer from progressive loss of muscle strength, typically rendering them wheelchair-bound before the age of 12 and most patients die in early adulthood due to respiratory and cardiac failure. At present, there is no effective treatment for DMD. The goal of the SCOPE-DMD project is to develop a therapy that can restore the expression of a functional dystrophin protein in a targeted DMD patient sub-population. This will be achieved using RNA-based technology, specifically antisense oligonucleotides (AON) inducing exon skipping. The clinical heterogeneity and disease complexity in rare diseases present a major challenge to properly observe statistically and clinically meaningful treatment effects. Innovative clinical study designs and novel outcome measures are required to reduce development timelines.  Based on extensive experience from classical clinical trials of two other AONs in DMD patients, the consortium has designed a highly innovative development plan, including an innovative clinical trial design that if successful, could be applied to future clinical trials in DMD and other rare diseases. Also novel biomarkers and functional outcome measures will be incorporated in additional to more established ones. Multiple layers of expertise and scientific knowledge come together in this SCOPE-DMD project consortium to launch an innova
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Entry-Level Hiring in Tightening Labor Markets: Frictions, Firm Heterogeneity and Public Policy' (ENTRYHIRE), addressing dissemination and exploitation.

assistant: **Impact**

Firms’ hiring of labor market entrants is crucial for individual access to opportunity and the economy’s skill level. However, it involves a complex search and screening process that is prone to frictions. While macroeconomic research has shown that the efficiency of labor market matching depends on recruitment intensity, micro-level evidence on firms’ underlying behavior remains limited, mainly due to a lack of suitable data. Yet, such evidence is essential for understanding and improving labor market matching, particularly given ongoing demographic change and increasing market tightness in many economies.The objective of ENTRYHIRE is to provide a systematic understanding of (i) firms’ hiring behavior and outcomes in tightening entry-level labor markets, (ii) the nature of underlying frictions and firm heterogeneity, and (iii) the effects of policies aimed at removing hiring frictions. As a ‘laboratory’ for studying the microeconomics of entry-level hiring, I draw on the German apprenticeship market, which features well-defined vacancy and applicant pools, a structured timeline, as well as exogenous tightness and policy variation.ENTRYHIRE will collect and combine novel data from different sources, including employer-employee records, a matching platform, and the records of a large-scale hiring assistance program. Moreover, it will develop and implement a survey framework to elicit firms’ hiring tradeoffs. Combined with innovative empirical research designs, the collected data will enable a comprehensive view on firms' typically unobserved search and screening processes and their links to realized hiring outcomes.The project will create systematic knowledge on the interaction between labor market tightness, firms’ hiring behavior, and public policy on entry-level marke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'The future of food safety in the european union: building the european research area'.

assistant: **Innovation**

Despite its importance, the approach towards food safety in Europe has until now been fragmented and young people have had insufficient incentive to work in this field. The objective of this project is to hold a series of seven seminars in 2002 and 2003 on key topics in food safety and its implications for consumers. The seminars will include contributions from leading food safety scientists, regulators, policy makers and representatives from industry and consumer organisations. Young scientists and PhD students will be selected from throughout the EU and from candidate member countries. The expected results of the project are a greater consensus of opinion priority topics in food safety research and improved networking of young scientists and students , encouraging career development and interdisciplinary collaboration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing and QUantifying the ATlantic Instrumental hydroClimate' in the context of a Horizon 2020 call.

assistant: **Objectives**

Precipitation (P) and runoff (R) variability around the tropical and subtropical Atlantic is of fundamental importance to the biosphere and carbon system, and to human livelihood. Over recent decades, decadal variations in P and R — including droughts in the Sahel region of West Africa, northeast Brazil, the Caribbean, and the Amazon basin — have caused large social and economic disruptions. However, understanding the causes of these events, as well as projecting regional 21st century climate change hydroclimate impacts, are complicated by the relative shortness in the instrumental record, which reduces confidence in the attribution of external forcings.AQUATIC will extend the record of Atlantic-sector hydroclimate variability during the 1880–1950 period. We will: (1) compile an integrated hydroclimate dataset including newly-recovered P station gauge data, long-term river R measurements, and a unique long-term record of Atlantic sea surface salinity which we will use as an “ocean rain gauge” to infer the surface evaporation (E)–P–R balance. We will then (2) examine these integrated hydroclimate data along with atmospheric and ocean reanalysis output to characterize mechanisms of decadal-to-multidecadal hydroclimate variability, including shifts of the intertropical convergence zone (ITCZ) and expansion and contraction of the Hadley circulation. This will allow us to (3) evaluate the Coupled Model Intercomparison Project Phase 6 (CMIP6) simulations to attribute long-term hydrological change to different external forcings, and constrain future climate projections.AQUATIC will combine analysis of early instrumental historical climate data with state-of-the-art reanalysis and model output to understand mechanisms of hydroclimate variability in and around the Atlantic and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SmartCow: an integrated infrastructure for increased research capability and innovation in the European cattle sector' (SmartCow).

assistant: **Innovation**

SmartCow integrates key European cattle research infrastructures, to promote their coordinated use and development and thereby help the European cattle sector face the challenge of sustainable production. Covering all the relevant scientific fields and the diversity of cattle types and production systems, SmartCow will provide the academic and private research communities with easy access to 11 major research infrastructures from 7 countries (18 installations) of high quality services and resources. These are needed to develop innovative and ethical solutions for efficient use of animal and feed resources that promote animal welfare and healthy livestock, as well as sustainable competitiveness.SmartCow combines strong scientific and technical skills in animal nutrition (in vivo methods for nutrient utilisation and emissions measurements), genetics (genotyped animals, phenotyping capabilities), health and welfare (sensors and automatic recordings of physiological and behavioural traits) and ethics in animal experimentation. A central promotion and management of transnational access to the research infrastructures will provide access to around 10,000 cow.weeks and facilitate up to 33 research projects involving 59 users. Networking activities will harmonise and standardise procedures especially in animal care and measurements, design of experiments, data recording and analysis thanks to a cloud-based data-platform specifically developed in the project. Joint research activities will produce refined methods and proxies to evaluate feed efficiency and emissions, develop new protocols to reduce the use of animals and produce new methods to exploit sensor data for cattle husbandry. Promotion of transnational access and dissemination of SmartCow outcomes and innovations for ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Structural Basis for Centromere-Mediated Control of Error-free Chromosome Segregation' under Horizon Europe.

assistant: **Concept**

Accurate chromosome segregation during cell division requires bipolar attachment of sister-chromatids to microtubules emanating from opposite spindle poles and maintenance of sister-chromatid cohesion until all chromosomes achieve bi-orientation.  Two chromosomal sites regulate these processes: centromeres, the microtubule attachment sites defined by the enrichment of CENP-A nucleosomes, and the inner centromere, a region between the sister-chromatids that recruits enzymatic activities (kinases, phosphatases and motor proteins). The inner centromere associated enzymes selectively stabilise chromosome-microtubule attachments suitable for chromosome bi-orientation, control sister chromatid cohesion and achieve timely chromosome segregation. Errors in these processes can lead to aneuploidy, a numerical chromosomal aberration implicated in miscarriages, birth defects and cancers. Using an integrative structure-function approach (X-ray crystallography, cryo electron microscopy, Crosslinking/Mass Spectrometry, biochemical/biophysical methods with human cell-line based functional assays), we will obtain detailed mechanistic understanding of: (1) how the inner centromere is assembled, (2) how the inner centromere associated interaction network recruits regulators to achieve chromosome bi-orientation and accurate segregation, and (3) how centromere identity is maintained through multiple generations. This work builds on our recently obtained exciting structural/molecular knowledge that have led to unexpected insights and new questions and will exploit our recently generated battery of molecular reagents. Outcome of our work will provide unprecedented details of centromere-mediated control of chromosome segregation and allow us to build a comprehensive mechanistic model for error
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Near-infrared nucleic acids sensing and imaging using lanthanide-based nanoparticles capped with DNA' under Horizon 2020.

assistant: **Concept**

The Upbiosens project describes a novel method to produce water-dispersible and stable DNA-capped upconversion nanoparticles (UCNPs), keeping intact (or enhancing) the properties of both DNA and UCNPs. The UCNP@DNA nanohybrid will be able to detect the complementary target miRNA or DNA sequence. This detection will be based on the UCNP emission changes after NIR excitation in the presence of the fluorophore target RNA/DNA sequence. The hybridization will enable FRET from the UCNP to the fluorophore upon NIR irradiation, which will allow the quantitative measurement of nucleic acid. In addition, this new strategy for DNA functionalization of UCNPs will enable the control of the UCNP size during the functionalization step as well as the distance between UCNP and the energy acceptor. Both issues are critical for the design of novel, rapid, highly selective and sensitive FRET-based biosensors. This approach will be demonstrated for wo different compositions of UCNPs, NaYF4: Yb, Er (excitation at 980 nm) and NaYF4: Yb, Nd, Er (excitation at 800 nm) in order to enhance optical properties. The excitation at 800 nm reduces the overheating of biosamples due to the light absorption by water. Taking into account the exceptional UCNPs emissive properties, the capability for in vitro nucleic acid imaging of the nanobiosensor will also be evaluated. To our knowledge, the combination of a nucleic acid sensing and imaging using UCNP-based nanohybrids has not yet been attempted. This dual NIR NA biosensor/bioimaging nanohybrid can be promisingly bio-implemented, such as in prognosis, diagnostics and treatment of diseases, gene therapy, or forensic analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A European model for bioinformatics research and community education' to be submitted under Sixth Framework.

assistant: **Abstract**

The objective of this network is to draw together a wide group of experts throughout Europe who are involved in the use of information technology in the biomolecular sciences. The EMBRACE network will optimise informatics and information exploitation by pure and applied biological scientists in both the academic and commercial sectors. The network will work to integrate the major databases and software tools in bioinformatics, using existing methods and emerging Grid service technologies. The integration efforts will be driven by an expanding set of test problems representing key issues for bioinformatics service providers and end-user biologists. As a result, groups throughout Europe will be able to use the EMBRACE service interfaces for their own local or proprietary data and tools. The many publicly available collections of biomolecular information do a reasonable job for a given domain. Software tools to organise and analyse this information are available both in the public domain and commercially.Cross-references in these databases in principle allow inter-database navigation; however, the links are sparse and coarse-grained, and their exploitation requires biological knowledge and expert programming.The effect of this is to burden every serious bioinformatics centre with the task of maintaining local data and software, and supporting users in the nontrivial task of exploring the natural biological connections between data. This requires substantial human effort. Today's trend towards systems biology demands very much better connections between different domains of knowledge, and the weaknesses in information integration are becoming an intolerable hindrance. This network will address these weaknesses by enabling data providers and tool builders to standardise thei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reduction of tropospheric ozone formation in Europe by the employment of alternative industrial solvents' in the context of a Fourth Framework call.

assistant: **Objectives**

Photochemical air pollution is a serious environmental problem for many regions of Europe during the summer months. The atmospheric degradation of volatile organic compounds (VOCs) in the presence of nitrogen oxides (NOX) leads to the production of a range of harmful secondary pollutants such as ozone and peroxyacylnitrates (PAN). Ozone formation is of particular concern since it is known to have adverse effects on human health, vegetation, a variety of materials and is also a greenhouse gas Solvents constitute around 35% of the total VOC emissions in Europe and hence are a major contributory factor to oxidant formation. Chemical industries in the United States and Europe have now recognised that a switch from traditional solvents (aromatic and unsubstituted hydrocarbons and chlorocarbons) to oxygenated compounds is inevitable, both in terms of toxicity problems and to reduce the levels of oxidant formation in the troposphere. Indeed it has been estimated that if it were possible to replace all existing solvents by acetone, a reduction in ozone formation potential of around 75% would result. Hence, the potential importance of switching from traditional solvents to oxygenated compounds in control strategies for VOC emissions is clearly apparent. Thus it seems that replacement of many existing solvents will occur in the near future and that esters, glycol ethers and di-ethers will form a significant proportion of these future solvents. The purpose of this programme is to provide a scientific evaluation of oxidant formation arising from the use of these new solvent types. In particular, it is believed that scientifically based evaluations of the ozone formation potentials of these species will contribute to a cost-effective ozone control programme in Europe. It is proposed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ALGAE4IBD –FROM NATURE TO BEDSIDE- ALGAE BASED BIO COMPOUND FOR PREVENTION AND TREATMENT OF INFLAMMATION, PAIN AND IBD', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Algae4IBD's mission is to develop commercial products for Inflammatory Bowel Disease (IBD) prevention and treatment using aquatic natural biological resources. With the emerging developments in natural product, notable success has been achieved in discovering natural products and their synthetic structural analogues with anti-inflammatory activity. However, global biodiversity remains a largely unexploited resource for natural bioactive molecules with an enormous potential for developing commercial products with public health benefits. Micro and macroalgae, found in marine and freshwater, have been identified as promising sources of bioactive compounds including small molecules and secondary metabolites with a wide range of bioactivities as an antioxidant, anti-inflammatory and cancer preventive. Consumption of algae could, therefore, provide defence against chronic inflammatory diseases such as IBD, that until date have no effective cure. This project offers nature to bedside approach, using an entire development along the value chain for a new biodiscovery therapeutic approach by developing and examining algae-based compounds for IBD patients while guaranteeing algae's biodiversity preservation. We propose innovative solutions for increasing the use of algae-based ingredients and to ensure the science-based improvement of nutritional quality and its effect on public health. The researchers, companies and hospitals involved in the different stages of the project will use the biodiversity of algae, both micro and macro, as a wide source for bioactive compounds using state-of-the-art cultivation and extraction technologies for obtaining sufficient amounts of the bio-active molecules together with novel processing protocols.  It will result in novel algal-based, high-qual