RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Metagenomics and metabolomics studies of patients with Anorexia Nervosa to identify intestinal microbial mechanisms contributing to pathogenesis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Background: Anorexia nervosa (AN), a complex disorder characterized by self-starvation with obsessive thoughts of food resulting in extreme weight loss, carries the highest fatality rate of any psychiatric disease. There is no evidence that the prognosis of AN has improved throughout the 20th century. The role of an altered gut microbiota in the pathogenesis of various human disorders is under intense scrutiny since gut bacteria contribute to metabolic, neurological and immune pathways in the host. Recent advances in microbial DNA sequencing technologies and advanced bioinformatics combined with access to comprehensive microbial gene catalogues have resulted in accurate quantitative metagenomics analysis of the gut microbiota, the impact of which on host biology can be estimated by untargeted metabolomics.Objectives: At deep taxonomic and functional levels to identify which parts of the gut microbiome are altered in women with drug-naïve AN compared with a group of age-matched controls and to elucidate how an aberrant AN microbiome relates to AN phenotypes through the serum metabolome. Potential causality is explored in germ-free mice transplanted with stools from AN patients and controls.Approach:  The study sample consists of 152 carefully phenotyped women. Eighty have AN. Deep shot-gun sequencing of microbial DNA has been done on stools from all women. Similarly, fasting serum samples from all individuals have been analyzed applying state-of-the art untargeted metabolomics and lipidomics. In the outlined research program I will test the hypothesis that an aberrant gut microbiome relate to AN phenotypes via an altered serum metabolome. In mechanistic studies of germ-free mice I will examine if stools from AN patients affect body composition of this species as suggesti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Cocreate, Embrace'.

assistant: **Objectives**

CulturalRoad develops sustainable and population -wide accepted deployment plans for Cooperative, Connected, and Autonomous Mobility (CCAM) services by combining participatory planning with a novel Five-Pointed Star Rating system able to capture both cultural and geographical diversity. At its core, the project advocates for active engagement with local communities, gathering valuable insights on their mobility needs. Through participatory planning, stakeholders from various cultural backgrounds and geographical regions collaborate to share their mobility needs. This inclusive approach ensures that CCAM solutions are tailor-made to meet the distinct demands of each community, this is, it makes them vectors of a more equitable mobility.


**Keywords:** CCAM, Cultural Issues, Traffic Management, Infrastructure, Safety, Inclusivity & Equity, SUMPs, NUMPs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Carbon dioxide thematic network 2002-2005 (CO2NET2)'.

assistant: **Objectives**

CO2 Thematic Network will facilitate the development of CO2 capture and storage as a safe, technically feasible, socially acceptable mitigation option. This is one component of an overall strategy for the provision of a safe, secure, climate neutral energy supply for the European Union. Elimination technology development is included. The foundations of the European CO2 Thematic Network have been laid over the past 10 months by the CO2NET initiative supported and funded by the EC. Within 10 months, 29 organisations in 9 European countries and the EU funded CO2 projects have committed to support the Thematic Network to accelerate the enabling technologies towards CO2 emissions reduction and develop the European Research Area virtual Centre of Excellence for C02. Membership is expected to exceed 40 organisations in 2002.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Analysis weld pool on-line adaptive weld process control hazardous environments & manufacturing applications using neural networks', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The main benefit of NEUROWELD comes from the reduction of the number of weld defects and thus improving the security and reducing the repair cost as well as the costs of welding procedures development in laboratory by optimising the number of tests to be performed.So, such a development should increase the effectiveness of European end-users during their work for developing a welding process and during their welding operations. It will have an impact on the price of welded constructions, on the integrity of welded structures and will permit to progress in the way of the fully automatic welding process in hazardous environment and manufacturing applications.The following steps have been carried out under this EC project in order to successfully develop a NEUROWELD prototype which has been validated in industrial conditions using on-site production conditions ;- Development of an sensor capable to look the weld pool and measure the groove geometry (gap, Hilo) and the data processing algorithms.- Development of the Neural Network Controller used in auto-adaptive configuration,.- Integration of the Neural Network control system with a Fronius' automatic welding machine.- Teaching of the Neural Network and validation of the methodology with TIG, MIG/MAG and TIME twin on stainless steel, carbon steel and Aluminium.- Development of an appropriate methodology for qualifying welding procedure and systems, which use this kind of auto-adaptive control.Further to different tests on different metals using the complete NEUROWELD system for TIG, MIG/MAG as for T.I.M.E twin, the validations have been demonstrated that the concept of welding control by Neural Network is able to work correctly and to offer the best results for good and repetitive welds.All welding qualification results,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Antiferromagnetic straintronics: towards an non-volatile all-voltage controlled memory device'.

assistant: **Innovation**

The holy grail of magnetic storage research is the discovery of novel all-voltage controlled magnetic metamaterials that enable to develop a universal memory device that simultaneously meet high-power-efficiency and ultra-high storage capacity. Antiferromagnetic (AFM) materials could represent the future of spintronic applications as a result of the numerous interesting features they combine, e.g. they are robust against perturbation due to magnetic fields, produce no stray fields, display ultrafast dynamics and are capable of generating large magneto-transport effects. However, the truly distinctive feature posed by AFM materials when compared to ferromagnetic ones is its modulated magnetic order, which is marginally exploited in spintronics applications.The PiezoSpin project seeks to demonstrate a novel proof-of-concept for an innovative universal ultra-high power-efficient AFM-based spintronics memory device, which has the potential for transforming the ferromagnetic-dominated magnetic data storage technology. We will produce hybrid FeRh-based alloy/ferroelectric (FE) heterostructures, where the FeRh-based alloy overlayer will act as a resistive-switch driven by the FE underlayer acting as a voltage-controlled actuator. We will investigate the strain-dependent electrical resistivity of the FeRh-based alloy on the applied voltage. This piezo-magnetoresistivity effect will be optimized by chemical doping of the FeRh-based alloy to maximize that strain-dependent resistivity change at room temperature. This novel hybrid device concept exploits the strain-dependent giant magnetoresistance that appears in spin-orbit coupled (anisotropic) AFMs. Its origin resides in the superzones band-gap effect as a result of the onset of modulated magnetic order.  Such piezo-magnetoresis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The birth of protein complexes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Protein complexes are central to many cellular functions but our knowledge of how cells assemble protein complexes remains very sparse. Biophysical and structural data of assembly intermediates are extremely rare. Particularly in higher eukaryotes, it has become clear that complex assembly by random collision of subunits cannot cope with the spatial and temporal complexity of the intricate architecture of many cellular machines. Here I propose to combine systems biology approaches with in situ structural biology methods to visualize protein complex assembly. I want to investigate experimentally in which order the interfaces of protein complexes are formed and to which extent structures of assembly intermediates resemble those observed in fully assembled complexes. I want develop methods to systematically screen for additional factors involved in assembly pathways. I furthermore want to test the hypothesis that mechanisms must exist in eukaryotes that coordinate local mRNA translation with the ordered formation of protein complex interfaces. I believe that in order to understand assembly pathways, these processes, that so far are often studied autonomously, need to be considered jointly and in a protein complex centric manner. The research proposed here will bridge across these different scientific disciplines. In the long term, a better mechanistic understanding of protein complex assembly and the structural characterization of critical intermediates will be of high relevance for scenarios under which a cell’s protein quality control system has to cope with stress, such as aging and neurodegenerative diseases. It might also facilitate the more efficient industrial production of therapeutically relevant proteins.


**Keywords:** protein complex assembly, local translatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deglacial ocean and climate seasonality in laminated sediments from the East Antarctic margin' under Sixth Framework.

assistant: **Concept**

The biggest threat to mankind is climate change. Most scientists now agree that anthropogenic carbon emissions are not only detrimental to our environment, but have contributed to the causes of the rapid climate change we now face. The extent of mankind's overall contribution to this problem and how much is part of the natural climate cycle is an intriguing question.This project makes a contribution towards addressing this question by studying elements of the carbon cycle pre-Anthropogenic forcing during a period of rapid climate change in the recent past. In doing so it offers a temporal 'base-line' perspective of natural climate change processes and effects of atmosphere-hydrosphere-geosphere-biosphere interactions.Furthermore, it appears that we should look to the Antarctic to understand some of the causes of European climate change, which help influence environmental policy decisions. One way that Antarctic ice sheets and seasonal sea-ice melt can affect the climate system is through the sequestration of atmospheric CO2 to the ocean sediments via inducing enormous production of planktonic marine organisms.This occurred on an unprecedented scale over several hundred years during the last deglaciation as recorded by seasonality laminated (varved) sedimentary sequences across the East Antarctic Margin (EAM). This project uses organic microfossil remains and a new organic geochemical proxy for estimating past sea-surface temperatures (TEX86) to elucidate seasonal palaeoceanographic and palaeoecological changes across the EAM from these varved sequences.The outputs will be invaluable for estimations of carbon sequestration for a natural system during a period of rapid climate change and for climate models, which attempt to predict future global change and response of bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Metal complexes of a naturally inspired framework functionalized for cytotoxic and catalytic efficiency' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The immense power of practice-oriented synthetic chemistry is demonstrated through the opportunity to design, synthesize, optimize, produce and apply a molecule of a desirable structure for a given purpose. In the light of its ability to bridge chemical structure with a function, MET-EFFECT proposes brand new concept of novel multifunctional rhenium and iridium flavonoid complexes aimed to serve as metallodrugs and homogenous catalysts. The fusion of academic knowledge and industry-oriented perspective establishes a fruitful collaboration of an international and intersectoral profile. Well-recognized members of Consortium gains beyond the-state-of-the-art advances in bioinorganic chemistry by: a) developing novel Re and Ir complexes containing apigenin-like ligands, a natural bioactive flavone-type of molecules; b) determining the antitumor potential of newly synthesized Re(V) and Ir(III) complexes on a panel of various human cancer cell lines; c) evaluating the applicative potential of novel Re(V) complexes as homogeneous catalysts in OAT-inspired reactions (olefin epoxidation, oxoanions catalytic reduction and water oxidation). The structure and sentence of 7 work packages implemented through 37 secondments will enable the promotion of newly synthesized metal-based compounds in industrial environment for the sake of reaching their final applications. The widespread partnership creates an outstanding, R&I oriented ambient ensuring free knowledge sharing and career upgrade of the participating staff. By developing functional metal-based molecules, MET-EFFECT encompasses full human intellectual capacity capable to challenge technical, economic and environmental demands of wider society for applied but sustainable chemistry.


**Keywords:** rhenium, iridium, flavonoid, sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'VALIDATION OF AN INNOVATIVE SENSOR SYSTEM FOR GASMASKS TO PROTECT THE USER AGAINST HEALTH HAZARDS', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In the field of workers' safety, protective gasmasks play a major role as life saving equipment. However the use of such masks currently presents specific hazards. The most obvious case is that if the mask slips and the seal of the mask leaks: the wearer finds himself in an environment which is highly toxic. Similarly, long-term hazards occur which often go undetected when protection is interrupted (leaky or inefficient filter) but where the immediate effect on humans is not perceptible. In order to avoid the risk of using unsafe gasmasks, filters are usually changed too early, which increases the costs. In addition, the gasmask user has to endure a heavy psychological burden because he has to trust the gasmask but no on-line system exists to warn him in case of gasmask failure.The objective of the project was to validate an innovative mobile and self-monitoring sensor system and its integration within gasmasks. Research results had shown that an improved sensor system was able to detect toxic substances. However, the difficulty lies in how to adapt and optimize the sensor system to various gases.The applications focused on include users in the chemical industry, public and factory fire brigades, and other private security services.The project attempted to address the three main obstacles to the manufacturing of a marketable product :- adaptation of a sensor for use in a gasmask.- miniaturisation of the sensor to fit inside mask.- improvements power sources and battery life for mobile on-line operation, both for sensor and electronics.The technical requirements with regards to the design of the system were extremely high. Apart from the adaptation of a broad-band sensor element, the miniaturisation of the sensor system and its mobile operation also had to be guaranteed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NAD+ International Scientist-training' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Nicotinamide adenine dinucleotide (NAD+) is a central redox cofactor and the limiting substrate of key metabolic enzymes. The constellation of cellular functions in which NAD+ is involved makes its availability critical for cell survival, and its depletion is a leading factor in a number of diseases in humans, ranging from rare inherited defects to more common multifactorial, often age-related, complications, including type 2 diabetes, neurodegenerative diseases and female infertility. In contrast, NAD+-repletion strategies, such as administration of NAD+ precursors, may be effective in preventing or ameliorating the outcomes of these complications. NADIS partners have made pivotal discoveries in the field of NAD+ biology. First, by discovering novel mechanisms linking NAD+ metabolism to prevalent diseases such as type 2 diabetes, cancer cachexia, Alzheimer’s, Parkinson’s, or rare inherited mitochondrial disease, and to lifespan regulation. Second, by identifying lifestyle, nutritional, and drug interventions that target NAD+ metabolic pathways to combat such diseases and promote healthy aging.  Despite these recent advances, there are still major gaps in our current knowledge in regard to (1) how NAD+ homeostasis is regulated at different stages in life, (2) how its imbalance leads to disease at a systemic level and (3) which NAD+ repletion strategy is the most suitable to prevent or treat specific diseases.  It is the ambition of the NADIS consortium to fill these gaps by training the new generation of Early Stage Researchers (ESRs) on how to apply state-of-the-art tools to study the interconnection between metabolic cofactors, such as NAD+, and metabolic health at different levels, and to provide them with an interdisciplinary and intersectoral training programme tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Decoding subcellular spatial biology with high precision using RNA photocatalysts' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

RNA is a fundamental component of life. Complex, dynamic, and spatial networks of molecular interactions between RNAs and other biomolecules are essential for maintaining cellular homeostasis. Disruptions in the RNA interactome have been linked to a number of human diseases, implying that these molecular interactions could represent a new family of unexploited therapeutic targets. Despite the growing appreciation of the importance of RNA, discovery, and characterization of RNA interactions at the transcriptome level is lagging behind, mainly due to the limitations of the existing methods including low precision, low throughput, low coverage, biased analysis, complicated protocols involving cumbersome biochemical fractionation or cell-line engineering. With the present technology, many more years may pass before a comprehensive list of their functions, localizations, and interactions can be assembled, considering the immense size and complexity of the human transcriptome and RNA interactome.  This ERC project aims to establish a simple, versatile, and low-cost technology based-on photocatalytic proximity-labeling and the biRhoBAST aptamer for deciphering RNA-RNA and RNA-protein interactions with high precision for any given RNA at different resolutions, ranging from single-molecule to macromolecular complex level. Owing to its innovative design, this technology will seamlessly integrate with advanced super-resolution RNA imaging techniques, providing valuable insights into the intricate interaction networks of RNA with high temporal and spatial resolution. By applying this massively multiplexable technology to numerous biological settings and disease-related RNAs, we will expand our understanding of interactomes, uncover new insights into subcellular RNA structures and u