RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Deploying and unifying the NMR e-Infrastructure in System Biology' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

NMR plays an important role in life sciences (bio-NMR), and structural biology in particular, at both European and international levels. An I3 initiative is operative in the field, which provides access to NMR instrumentation and pursues technical advancement (EU-NMR). In addition, the EC has funded a Coordination action (NMR-Life) aimed at the establishment of common experimental approaches and at the spreading of best experimental practices across Europe. Altogether, these two initiatives provide a reference point for the large majority of European scientists with an interest in bio-NMR.<br/>In parallel, European developments in the area of Research Infrastructures in the past years resulted in a leading edge high-speed research network covering all Europe and in a overlaying production Grid infrastructure, realized by projects as EGEE/EGEE II. This integrated network and processing/storage environment – e-Infrastructure - provides a platform for new methods of global collaborative research – e-Science.<br/>The main objective of this project is to optimise and extend the use of the NMR Research Infrastructures of EU-NMR through the implementation of an e-Infrastructure in order  to provide the European bio-NMR user community with a platform integrating and streamlining the computational approaches necessary for bio-NMR data analysis (e-NMR). The e-NMR infrastructure will be based on the Grid infrastructure.<br/>The project will also tackle the following objectives: i) establish a human collaboration network between the bio-NMR and the e-Infrastructure scientific communities; ii) assess the state-of-the-art of the computational aspects of bio-NMR; iii) implement and make available state-of-the-art computational methods. A broad range of networking activities will focus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Establishing the meiotic recombination-initiation epigenetic code in the yeast Saccharomyces cerevisiae' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Meiotic recombination is initiated by programmed DNA double strand breaks (DSBs) catalysed by the evolutionary conserved Spo11 protein and associated factors.  In the yeast S. cerevisiae, the DSB sites are non-randomly distributed along the chromosomes: certain genomic regions have higher propensity to form DSBs than others, explaining the expansion and contraction of the genetic versus physical maps. The cis- and trans-acting factors that select the DSB sites in the chromatin architecture and make a particular region 'hot' or ‘cold’ are not elucidated. The aim of this project is to decipher the role of histone modifications and other types of chromatin structural elements that orchestrate the recruitment and/or the cleavage activity of the DSB-forming machinery along the chromosomes. In wild type and a panel of mutant strains defective in histone modifying and remodeling activities, we will assess the spatial and temporal dynamics of the histone modification landscape upon DSB formation on the genome-wide scale using the ChIP-Chip, ChIP-Seq, Re-ChIP and FAIRE techniques. The chromatin-state of hot and cold regions will be mapped both at natural and ectopic hot/cold spots using the Gal4BD-Spo11 protein that is suitable for the targeted stimulation of recombination at naturally cold but permissive (warmable) regions but not at other cold (refractory) regions located near centromeres and telomeres. Successful completion of these studies will (1) include the construction of complete, genome-wide maps of meiotic chromatin-state in wild type and mutant yeast strains, and (2) improve our knowledge on how Spo11-dependent DSB formation is differentially controlled in relation to the chromatin context and coupled to homologous recombination, and differ from other sources of DNA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigations of marine barite formation in the water column' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Marine barite accumulated in deep-sea sediments is widely used for paleoclimatere constructions. However, the mechanisms that drive barite formation are still poorly known. In this study, I propose to investigate the relationship between barite precipitation and the decay of organic matter by combining approaches at different scales. First, the spring phytoplankton bloom from the Scottish Sea Loch (Scotland) will be monitored over time using sediment traps for collecting the particulate matter. Special attention will be given to record the possible Ba depletion in seawater at the end of the spring bloom as has been reported by Stecher and Kogut (1999), while during the post-bloom period, I will focus on studying the relationship between the release of labile particulate Ba following the decay of labile organic matter and barite precipitation. In vitro experiments will also help understanding the prerequisites necessary for barite formation. Finally, the study of a transect along a productivity gradient in the North Pacific (sediment traps, large volume in situ pumps) will allow to investigate barite formation within an open ocean site, thus constituting a good reference for comparing the results obtained in the in situ (Loch) and in vitro experiments.These investigations are designed to bring insight on the mechanisms of barite formation within the water column. For a researcher career, I believe that a PhD degree needs to be completed by further investigation that can expand ones skills and area of action. I would like to dissect further the mechanisms (still unknown) that drive barite formation. I would like to gain further experience in field experiments conducted in oceanography (sampling using sediment traps, in situ pumps ), in in vitro experiments, and in the use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of rapid field diagnostics for identification, control and management of haemorrhagic fever outbreaks' in the context of a Sixth Framework call.

assistant: **Objectives**

This project proposes to develop and validate diagnostic tools for early viral haemorrhagic fever outbreak detection and control. A frontline line-assay carrying antigens of all African haemorrhagic fever viruses is to be developed and validated for widespread use in bush hospitals. This assay is easy to use and the results are easy to interpret. It is also cheap to produce and has a long shelf life. This tool will help to improve outbreak detection in Africa. The project includes long-term field trials in bush hospitals. A mobile integrated F-RT-PCR for outbreak investigation teams is to be developed. It will consist of a panel of F-RT-PCRs covering all haemorrhagic fever viruses, a robust simple nucleic acid extraction protocol and ready to use lyophilised PCR mixes. This tool will help outbreak investigation teams to improve their ability to manage and control haemorrhagic fever outbreaks. A consortium of 3 European laboratories and 4 African laboratories will provide the expertise for the development, validation and adaptation to filed use of both tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'On-site and On-demand Flexible Packaging System' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Agil Packaging System, S.L. (AGILPACK) reinvents the Major Household Appliances Packaging System (refrigerators, washing machines, dishwashers) replacing Expanded Polystyrene (EPS) with alveolar bubble wrap packaging pieces made from a new type of material: multilayer film.AGILPACK has developed the patented APS flexible system with the following characteristics: replaces packaging solutions using EPS with a new concept based on Bubble Multilayer Film; packaging comprises a set of three-dimensional parts formed by airtight bubbles made from film; it is a complete system including parts design software and machinery, installed at the end of client’s line.The Advantages for clients of APS system compared to actual ones are: APS solution has 30% lower cost than conventional EPS packaging; it is a flexible system because alveolar plastic bubble film parts are custom-made, on-site and on demand; it has a much better sustainability and lower carbon footprint; its easy recyclability leads to a circular economy solution; it helps companies comply with the increasingly stringent regulatory laws of cities and EU for EPS use.Wrapping bubble alveolar film parts have been produced and tested, a software for parts design and calculation has been designed, machine modules prototypes have been developed and tested and the system is ready for optimization at industrial pilot level in a client’s plant.The market target is the bulky white line household appliances packaging sector accounting for more than €177 million in EU and €2.3 billion worldwide.APS highly scalable system will allow AGILPACK, by 2024, to be servicing 16 clients’ plants and to reach a total turnover of €50.9 million.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cross-Modal Perceptual Display: a New Generation of Audiovisual Virtual Environments' (CROSSMOD) targeting Sixth Framework.

assistant: **Abstract**

Virtual environments (VEs) play an increasingly important role in our society. Currently two main sensorial channels are exploited in VEs: visual and auditory, although sound is greatly underused. The ever-increasing scene complexity of VEs means that it is currently not possible to display highly realistic scenes in real time despite the availability of modern high-performance graphics and audio processors. However, the realism and quality of a virtual image/sound needs to be as good as what the user can perceive: we only need to display what is necessary. Despite recent research, little work exists on cross-modal effects, i.e., the effects that each channel (visual and auditory) has on the other, to improve the efficiency and quality of VEs. CROSSMOD will study these effects and develop a better understanding of how perceptual issues affect auditory/visual display; this understanding will lead to the development of novel algorithms for selectively rendering VEs. The cross-modal effects studied will potentially include the effect of spatial/latency congruence on quality perception, attention-control, sound-induced changes in visual perception and foveal/peripheral audiovisual effects. These initial experiments will be guided by their applicability to the improvement of VE display and authoring. An integrated cross-modal manager will be developed, using results of the initial experiments identifying which cross-modal effects are useful for VE display. The solutions developed by CROSSMOD will enable the display of perceptually highly realistic environments in real time even for very complex scenes, as well as the use of active cross-modal effects such as attention control in the display and authoring of VEs. We will evaluate our hypotheses with further experiments in rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Concerted Action to foster prevention and best response to Accidental Marine Pollution' (AMPERA).

assistant: **Innovation**

Marine pollution, in general, and accidental marine pollution, in particular, are issues of major concern from the standpoint of their impacts on the health of the marine environment and their socio-economic uses. These issues have played an important pressure upon the need for a better protection of the world's marine ecosystems through the implementation of new or improved prevention mechanisms and response actions, based on sound scientific principles. Taking into account that these problems are also very often of transboundary nature, we envision to create a platform where governmental policy makers and scientists from European coastal countries meet and discuss all aspects of accidental marine pollution research and implement measures needed. This follows the international co-operation strategy defined within the ERA initiative, enhancing European competitiveness and providing the basis for the best practices on prevention, avoidance and remediation of accidental marine pollution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Computation information technologies for environmental sciences : support to organization of international conference and school.' (CITES).

assistant: **Concept**

The aim of the Proposal is to support organization of international conference and young scientists school on computational information technologies for environmental sciences in Toms (Russia) in September 1-10, 2003, which will fill a gap between basic science achievements and their applications in these domains and provide a solid foundation for mitigation of pollution in selected areas. Also it is planned to use the Conference for giving transparency and diffusion to the target audience the work performed within environmentally oriented projects sponsored by INTAS, NATO, ISTC, CRDF and 6th FP in general. The scientific results will be disseminated by weans of special WWW-server, proceedings and a special issue of an international journal. Consolidation of EU-NIS cooperation in the field of interest is expected. The proposed measure will contribute to main objectives of the INCO Programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Decoding the regulatory control of floral induction in apple (Malus domestica)' (FlowCODE).

assistant: **Concept**

Floral induction (FI), the decision enabling a meristem to become floral, is important to reproductive success and yield production, yet its transcriptional regulation is virtually unknown in apple and other fruit tree species. The central FI mechanism appears conserved in all species in which it has been studied, although it is the regulation that enables environmental adaptation. FI is activated via multiple environmental and internal cues, mediated through various flowering pathways and converging at the highly homologous genes, FLOWERING LOCUS T (FT) and TERMINAL FLOWER 1 (TFL1), which act as an FI promoter and inhibitor, respectively. In Arabidopsis, flowering pathways have been extensively studied; however, the perennial lifecycle, dormancy requirements and flowering behaviour of apple, in addition to the ancestral duplication of the genome, mean FI control is likely very different in this species. The transcription factors (TF) and cis binding motifs identified in Arabidopsis provide a starting point from which to unravel apple FI regulation and it appears the GA pathway may also play an important role. FlowCODE will decipher the molecular control of FI in apple by identifying TFs that control transcription of FT- and TFL1-like genes and how they affect this expression. Equally, regulatory elements within the apple FT and TFL1 genes will also be ascertained. The significant genetic variation in FI-related traits, such as the proportion of floral buds per tree, across apple varieties will be used as a tool to link molecular regulation with its phenotypic effects. Additionally, studying this regulation in the context of the GA pathway will provide insight into its role in influencing this variation in FI behaviour. In deciphering FI regulation, possible approaches
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NANODELIVERY OF SPECIFIC GENOME ENGINEERING TOOLS AS A NOVEL THERAPEUTIC APPROACH FOR AGGRESSIVE PROSTATE CANCERS' (NANOCRISPR).

assistant: **Concept**

Prostate cancer is the second most common diagnosed malignancy and the fifth leading cause of cancer mortality in men. Whilst primary tumours respond well to therapy, tumours in the metastatic setting become inherently resistant to chemotherapy. Thus, more novel and effective therapeutic approaches are highly needed to treat this lethal disease.The cornerstone treatment for advanced prostate cancer consists of androgen deprivation therapy and docetaxel (DTX). However, both DTX activity and Androgen receptor (AR) signalling are highly interrelated. On the one hand, it has been shown that DTX is able to inhibit Androgen Receptor (AR) signalling and on the other hand, the activation of AR signaling can induce DTX insensitivity. In order to break this dependency of DTX effectiveness on AR signaling and ensure efficient treatment for advanced prostate cancer, we propose the selective inhibition of AR deploying CRISPR/Cas9 technology together with DTX. Both therapeutical approaches will be encapsulated into prostate-specific targeted nanoparticles which will allow the simultaneous delivery of the drug and CRISPR plasmids targeting AR into the tumour site. The designed state-of-art multi-functional nanoparticles will reprogram and sensitise the prostate tumour to DTX in situ, and will also induce a higher accumulation of the treatment in the tumour while healthy tissues will remain less affected. Moreover, the use of CRISPR/Cas9 will precisely engineer the prostate cancer cells to express lower levels of AR, contrasting with current anti-AR treatments, which have multiple off-targets.This approach represents an innovative targeted therapy for advanced prostate cancer. It will allow the administration of lower doses of chemotherapy with consequently reduced toxicity and the pot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Interdisciplinary doctoral training on oligonucleotide-based therapies for myotonic dystrophy'.

assistant: **Objectives**

Rare diseases, though individually infrequent, collectively pose important challenges for patients, clinicians and researchers in terms of diagnostics, healthcare and treatment. Myotonic Dystrophy (DM), the most predominant inherited muscular dystrophy in adults, impacts 60,000-70,000 individuals in Europe. Its complex genetic and clinical variability result in a lack of robust genotype-phenotype correlations, which complicates the understanding of tissue-specific disease mechanisms, the development of effective therapies and the stratification of patients into well-defined clinical groups for clinical trial purposes. In recent years, Antisense Oligonucleotides (ASO) have emerged as promising therapeutics, notably in neuromuscular disorders. However, previous clinical trials in DM have failed due the reduced efficacy and bioavailability of the ASO tested. ENTRY-DM aims to train 14 DCs in translational research, through the combination of basic and clinical competencies across multiple disciplines, as well as strong soft and transferable skills. Our interdisciplinary network seeks to enhance scientific and technological knowledge, spanning from disease mechanisms, ASO design and delivery strategies, to clinical trial preparedness, using innovative multidisciplinary approaches and best practices. The consortium includes experts in DM research, bioengineering of model systems for preclinical drug screening, ASO chemistry, as well as clinical and neuropsychological assessment. Close collaborations with multi-sectoral partners will address the challenges in technology transfer, providing high-quality bench-to-bedside training to the next generation of researchers. Through these efforts, ENTRY-DM will catalyze ASO therapeutic development towards upcoming impeding clinical tri