RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deposition of Hard Metallic Oxides at Low Temperatures' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives and content There is a clear industrial need for the development of hard, wear resistant coatings which are chemically inert and which can be deposited at low temperatures (< = 500°C) via an environmentally friendly process. All these criteria can be satisfied in principle, by the growth of alpha alumina (Al203) utilising plasma enhanced processes. However, this has not yet been achieved by any laboratory in the world. The aim of the present proposal is to identify the conditions under which the (hard) AI203 phase can be grown at low temperatures and hence to implement the growth of this phase using PVD techniques of the type that are available commercially. To this end, we shall utilise two different, but complementary, deposition growth techniques viz plasma enhanced deposition and molecular beam epitaxy (MBE). The former technique has been used by one of the partners (Linköping University), in the low temperature growth of high quality SiC. The MBE technique, with which another of the partners (the University of Hull) has extensive experience for the growth of compound semiconductors, provides a powerful investigative tool, for the study of basic growth processes. These investigations, carried out b.,v both groups, will proceed from 'ideal' substrates (e.g. sapphire) to the more complex ones of relevance to industry (e.g. alloy steels). The growth investigations will be supplemented strongly by state-of-the-art characterisation techniques at the Universita degli Studi di Ancona and Linköping University (e.g. XRD, TEM) and by theoretical modelling at the University of Hull. These will help to identify the range of conditions for the realisation of growth of &-Al203 on a given substrate. For example modelling can help identify the range of compositions under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mobile E-work and E-commerce Secured Transaction' (MEEST).

assistant: **Concept**

The object of MEEST is to develop a method and system that will enable people to perform a broad array of ubiquitous mobile e- commerce & e- work functions using their mobile handsets. By using MEEST technology every person anywhere and any time, will be able as a consumers to use his mobile phone as a safe and secure tool in order to pay for e- commerce & e- work services. The project will be based on the GSM/ GPRS technology on its first phase and will be adjust to 3rd generation according to its usage. The R&D activities of MEEST also include a WAP application, which will enable a broad array of e-work and e-Commerce implementations.Work description:The planning of the project is based on stellar work packages starting at day one, enabling each partner to lead the work packages based on his expertise, and enabling multi tasking and merging of most work packages into common stage in time when all testing and integration activities take place after the first stage a small scale marketing trial is taking place in order to test the system and to ensure that end-users' feedbacks, results and conclusions are incorporated into the system before large scale trial and commercial deployment. The challenges to gap within this project are: Provide a robust and reliable security level to commercial transactions over the Cellular medium (e.g. integrating 3DES standard into the SIM) Provide connectivity and interfacing to all varieties of cellular networks, operators, handsets and financial institutes Provide connectivity to all variety of merchants and retailers Provide Customer Relations Management solutions for M-Commerce Enable the system the evolution from existing GSM and cellular technology into WAP/GPRS and 3rd generation Enable the M-Commerce application to be loaded and u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of an artificial alkane monooxygenase: A leap in bioinspired oxidation catalysis'.

assistant: **Innovation**

The oxygenation of inert C-H bonds is a highly challenging reaction that has an enormous untapped potential for the European chemical industry. Indeed, it offers attractive means to upgrade cheap hydrocarbons into high value-added products. Nature relies on iron-based enzymes and oxygen to perform such transformations. In a biomimetic spirit, catalytic alkane hydroxylation is best achieved using iron-based catalysts and H2O2 as oxidant. Compared to natural enzymes, however, such systems display modest performance. In the TAML-ArM project, we aim to the development of a novel approach that consists of creating an artificial alkane monooxygenase by introducing a highly active iron complex within a protein scaffold. This strategy, pioneered in the Ward group, has ample precedent for less challenging reactions, and it potentially represents a significant step forward in bioinspired hydroxylation chemistry. To achieve this goal artificial metalloenzymes merge homogeneous- and enzymatic catalysis, two traditionally complementary strategies. We envision that this approach will: i) improve the catalytic activity by protecting the highly reactive Fe=O-moiety by shielding it from undesirable side-reactions and ii) provide novel selectivities, owing to second coordination sphere interactions between the protein and the substrate. Thanks to this innovative catalytic approach, we will develop a paradigm shifting technology for the selective hydroxylation of hydrocarbons: the reactions will be performed in water at room temperature using benign H2O2 as oxidant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular mechanisms involved in skeletal muscle repair and muscular dystrophy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of this proposal is to define the role of histone deacetylase 4 (HDAC4) and myocyte enhancer factor 2 (MEF2) in muscle regeneration and dystrophy. In response to injury, skeletal muscle activates orchestrated molecular mechanisms to restore muscle architecture and functionality.  Our preliminary data showed that skeletal muscle from mice lacking HDAC4, an inhibitor of the myogenic factor MEF2, regenerates better than that of control mice following injury. MEF2 activity is triggered in healthy myofibers surrounding the injured area, suggesting a potential role of MEF2 in paracrine regulation of adult muscle regeneration. We demonstrated that MEF2 controls the expression of caveolin3, an inhibitor of myostatin, a negative regulator of muscle mass. In this proposal, we plan to define the role of HDAC4 in muscle regeneration by identifying the targets responsible for the improved regeneration observed in HDAC4 null mice. We intend to study how HDAC4 regulates satellite cell proliferation and differentiation. In order to identify secreted factors that may contribute to the improved regeneration in HDAC4 null mice, we plan to perform a proteomic analysis on secretomes from HDAC4 null and control myofibers. Muscular dystrophies are a hereditary myopathies characterized by progressive muscle degeneration and weakness. Promoting muscle repair has been shown to be therapeutically beneficial for muscular dystrophy. We intend to study the role of HDAC4 in muscular dystrophy by characterizing mdx mice lacking HDAC4 in skeletal muscle. We will define MEF2 activity and we will determine target genes controlled by HDAC4 in muscular dystrophy. By delineating the role of HDAC4 in skeletal muscle regeneration and dystrophy, we will provide an experimental framework for devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The nanoscale control of reactive fluids  on geological processes within the solid Earth'.

assistant: **Concept**

Fluid-driven mineral reactions chemically modify enormous portions of the Earth’s crystalline lithosphere. These reactions drive fluid-mediated rock transformation processes that governs the stability of mountain belts, the formation of hydrothermal mineral deposits and the sequestration of anthropogenic CO2 as well as many other processes. I propose that contrary to our current thinking, the re-actions themselves are driven by self-promoting nanoscale transport phenomena.Existing geological frameworks lack a quantitative understanding of mechanisms that control the rates of reactive fluid-rock interaction. This is because they do not account for the pervasive influence of nanoscale dynamics on the redistribution of elements within geological materials. The nanoEARTH project will solve this by defining the predominant transport processes occurring in mineral nanopores and the dynamic behaviour of fluid-rock interaction.To achieve the nanoEARTH aims and break through current limitations in our understanding of fluid-rock interaction, I will use my expertise in the multi-scale physics of geological processes. I will combine (1) novel nanoscale experiments that will establish transport mechanisms through natural and synthetic mineral nanopores and (2) unique in operando observations of fluid-driven mineral transformations at multiple length scales with (3) molecular-to continuum-scale transport modelling that is (4) constrained by geological observations.Through this integrative strategy, I will deliver new knowledge to redefine how the reaction of fluids with minerals self-generates a mode of transport that mobilises elements and controls the rates of fluid-driven transformation. This will impact geoscience research well beyond the project duration and bring the nanoscien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Law and cultural heritage in Europe' (LAWCULTHERITEURO) targeting Sixth Framework.

assistant: **Abstract**

The project maps and critically examines the development of the definition and protection of 'European' cultural heritage in European and international law. It considers whether current legal regimes facilitate the European Union's objective of promoting cultural diversity.It focuses on European legal frameworks established in three principal areas:- within Europe, created at the supranational level by the EU and the Council of Europe and the national level by Member States;- inside and outside the EU, formulated to protect the cultural heritage of non-state groups; and- beyond Europe, to protect cultural heritage through external affairs.By exploring how these elements interrelate, the project seeks to discern an 'European' approach to conceptualising and protecting cultural heritage in law. From a scientific viewpoint, there is increasing emphasis in Europe and globally on the effective legal protection of cultural heritage.There is presently no specialist study complying, mapping and analysing European domestic and multilateral legal frameworks in this field. By filling this gap, the project promotes future individual and collaborative research and transfer of knowledge between Europe and Australia, and Asia Pacific; and formulation and implementation of internal and external EU policies.From a societal perspective, the EU and Council of Europe recognise the importance of cultural heritage and diversity for European integration, intercultural dialogue, peace and stability, economic competitiveness, sustainable development, and external affairs policy. The project embraces the Call and Work Programme's promotion of interdisciplinary and intersectoral research.The broad scientific and societal issues of this research area mandate an interdisciplinary methodology engagi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Consolidating Empire: Reconstructing Hegemonic Practices of the Middle Assyrian Empire at the Late Bronze Age Fortified Estate of Tell Sabi Abyad, Syria, ca. 1230 – 1180 BC' (2007-2013).

assistant: **Concept**

The origins of imperialism, a socio-military system in which hegemony is achieved over alien territories, are poorly investigated. This applies in particular to how imperial strategies affected local communities. This project will investigate the hegemonic practices of one of the earliest stable empires: that of the Assyrians, by focussing on the Late Bronze Age fortified estate at Tell Sabi Abyad, ca. 1230-1180 BC.The Assyrians created a network of strongholds in conquered territories to consolidate their hegemony. The fortified estate at Tell Sabi Abyad is the only extensively investigated of these Assyrian settlements. This settlement is both small and well preserved and has been completely excavated. The complete plan facilitates a study of the spatial properties of this fortress and how it structured interactions.  Further, the estate contained a wealth of in situ finds, which allow for a reconstruction of activity patterns in the settlement. Finally, over 400 cuneiform tablets were found which shed light on the local social and economic situation and the broader imperial context.This project will provide a bottom up perspective on the Assyrian Empire. Elements of the Tell Sabi Abyad estate that will be investigated include: spatial characteristics; activity areas; the agricultural economy; and the surrounding landscape. Further, data from the Middle Assyrian Empire at large will be reconsidered, in order to achieve a better understanding of how this empire was constituted. This project is innovative because: it investigates a spatial continuum ranging from room to empire; brings together types of data usually investigated in isolation, such as texts and artifacts; will involve the use of novel techniques; and will investigate the short term normally beyond the sco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Glial-neuron crosstalk in the regulation of neurofilament dynamics' under Horizon Europe.

assistant: **Concept**

Accurate communication between the central nervous system and the periphery requires rapid and efficient transmission of action potentials along the axon. Glial cells and neurons cooperate to regulate axonal conduction, and normal physiology of the nervous system is strongly dependent on the crosstalk between the two systems. Neurofilaments (NFs), the most abundant components of the neuronal cytoskeleton are a key target of the crosstalk that regulates electrical conductance. Nevertheless, the mechanisms by which the glial-neuron crosstalk regulates NF dynamics are currently not well understood. Yet this knowledge is of great importance, as disturbances in this system underlie disease mechanisms in various neurodegenerative diseases. In the GliaNFish project, top-notch techniques will be combined to capture for the very first time real-time dynamics of NF transport and NF-protein interactions in a living organism (zebrafish larvae), to understand the role of glia-neuron crosstalk in nervous system physiology. The project encompasses three objectives which aim to investigate: 1) NF organization and dynamics in vivo; 2) the impact of (de)myelination on NF organization and dynamics; and 3) the molecular players involved in the outside-in signalling cascade that regulate NF dynamics. The outcomes of the project will advance our understanding of NF dynamics and signalling in vivo, and on how myelinating glia and neurons synergize to enable signal conduction in the nervous system. This knowledge may permit in the future to explore how disturbances in this system lead to disease and will pave the way for novel therapeutic strategies towards NF dynamics. Overall, this project is extremely timely and relevant, as the social and economic burden of neurodegenerative diseases is ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of environmental guidelines for the region of Western Balkans' to be submitted under Sixth Framework.

assistant: **Abstract**

The main objective of WEB-ENV project is the development of general environmental guidelines concerning the region of Western Balkan Countries, with a particular focus on water resources, renewable energy and use of recycled materials. These guidelines could be useful for the management of major environmental problems and natural resources as well.This will be reached by the following:- Extended mapping exercise to identify these problems- Development of evaluation criteria permitting the selection of the most significant problems, taking into account the socio-economic and human health impacts- Assessment of innovative low-cost remediation technologies- Review of the existing legislation A consortium composed by CERTH (coordinator) and 5 other partners from the academic community representing 4 from the 5 countries of the region assures an adequate regional participation.An integrated dissemination plan foresees activities like: development of an environmental web portal, organization of workshops, and participation in worldwide environmental events like congresses, conferences, exhibitions etc. The development of general environmental guidelines is expected to contribute to the formation of a common environmental policy and sustainable management of natural resources, to arise peoples' sensitivity in crucial environmental problems, to contribute to the economic development and to provide assistance to all the stakeholders involved with the enhancement of the political and social situation in Western Balkans.The expected results contribute to INCO general objectives encouraging the transregional partnership and international cooperation and aiming at the prevention and re-mediation of environmental problems both in regional and global dimension of the area, to EU Water
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Changing Perceptions of Security and Interventions' (CPSI) targeting Seventh Framework.

assistant: **Abstract**

The goal of the present project is to provide governments and related organizations with a methodology to increase insight into the determinants of actual and perceived security, and into which interventions are effective for increasing security. The deliverables of this project represent practical and ready-to-use tools, which can be employed by policy makers and other end-users, to formulate policy regarding security. This project is a re-submittal of a proposal for PASR in 2006. In this project we will develop 1) a conceptual model of actual and perceived security and their determinants, 2) a methodology to collect, quantify, organize, analyse and interpret security-related data, 3) a data warehouse to store and extract for analysis data amassed using the methodology, and 4) carry out a validation study to test the model, methodology and data warehouse. We will test if it is possible to answer relevant security-related questions from the field using the methodology. The project deliverables can be used by end-users to assess security at the international, national and local levels and to draw conclusions regarding such issues as: What are the levels of actual and perceived security in specific locations?, Which interventions work where?, and Which interventions should be implemented in which locations?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Feasibility study for certified reference materials for organic components in sewage sludge' (SLUDGESUPPORT) under Fifth Framework.

assistant: **Objectives**

As a consequence of the revision of the European sludge directive, where limit values for certain organic compounds will be set, a need for general acceptance of laboratory results produced throughout the EC (including the candidate member states) has developed. In response to this need, a feasibility study on CRM production and certification will be carried out. The consortium members carry expertise on determination of the relevant compound groups in sludge as well as on exploitation and dissemination of certified reference materials. Selected candidate sludges will be investigated for their suitability as reference materials, and taken through a production and test certification procedure. The production process an techniques will be described in detail, and a Technical Implementation Plan will show how the new knowledge will be explicated.