RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Speeding up the development and adoption of XBRL in Europe'.

assistant: **Objectives**

XBRL is a royalty-free open standard for identifying and better communicating the complex financial information in corporate business reports. XBRL makes the analysis and exchange of corporate financial information easier and more reliable, providing benefits to all members of the financial information supply chain. Governments, regulators, exchanges, investors, analysts, financial institutions, and the European corporate reporting environment at large, as well as key third parties such as software developers, systems integrators, consultants and data aggregators. XBRL is being developed by XBRL International, a non-profit consortium of over 200 leading companies, associations and government agencies around the world. XBRL has now emerged as the only global XML-Based Standard for financial reporting.Conditions for XBRL adoption are developing rapidly, but Europe's ability to reap the benefits, depends upon continued:- proactive involvement and cooperation among reporting supply chain stakeholders- effective sharing of knowledge, information and tools across Europe- development of XBRL vocabularies (taxonomies) and applications to sustain progress and overcome the inertia of companies and government agencies to drive change.The pace of adoption should now move beyond what can be achieved by the goodwill and unilateral efforts of individual organisations. However, no European platform currently exists to do this or to connect stakeholders and coordinate efforts, Organisations will adopt XBRL more readily when it is seen as inevitable and to be making continued broad progress.This initiative is designed to speed up XBRL adoption, build awareness, and coordinate all XBRL activities throughout Europe, whilst continuing to leverage, and work in alignment with, XBRL Internatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Securing future-proof environmentally compatible bioenergy chains' (SECURECHAIN), addressing dissemination and exploitation.

assistant: **Impact**

SecureChain promotes a Sustainable Supply Chain Management (SSCM) that meets highest environmental quality standards and targets local biomass suppliers, energy producers and financial sector players to mobilise more biomass, maximise the share of sustainable bioenergy in the final energy consumption, and reduce the transaction costs for further market uptake of most efficient systems in six European model regions. An open call for SSCM pilot projects is launched encouraging market actors to mobilise and secure additional supplies of biomass from regional sources. Following a merit-based, objective competition, selected SMEs are awarded 15-20 Innovation Vouchers for the realisation of proposed SSCM pilot projects with the support of specialised advisors. Learning Labs for SME clusters support the implementation of most sustainable and energy efficient solutions in each model region. Tested quality assurance tools are readily installed in the pilots and SMEs receive proper training. A complete LCA of pilot supply chains evaluates their broader environmental and socio-economic impacts, ensuring that QA protocols meet eligible international sustainability standards for high efficiency and low carbon footprint. Suppliers are prepared for and ultimately acquire sustainability certification via independent audits. To facilitate critical financial proofs for market actors and financiers, a risk assessment of supply chains in line with a close mentoring of pilot teams by financial advisors is carried out. Roadshows promoting the pilots showcase that future-proof investment proposals can attract local to international capital for secured implementation and upscaling of efficient solutions. SecureChain exploits and disseminates a broadly transferable SSCM model for local bioenerg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Biological Effects on Isotopically Evaluated Systems'.

assistant: **Concept**

Reliable and robust methods for determining iron, zinc and copper status in the general population are needed. High precision natural intrinsic isotopic techniques originating in Earth Sciences can be used to reveal elusive metal pathways. The tight energy controls in biological systems mean that the isotope effect is seen in different metal-protein environments, depending on the ligand coordination and, if relevant, the oxidation state of the metal. When metal pathways adjust, due to increased or decreased uptake, excretion or another metabolic change, the isotope composition of a metal reservoir reflects this. Recent studies have indicated that these high precision isotopic analyses of blood may provide a new reliable method to determine metal status and disease.However, the interpretation of high precision isotopic data currently relies on computational models and plant-based laboratory experiments, and these assumptions are not sufficient to constrain isotopic signatures in human biological systems. Accurate interpretation of the isotopic signature is key to understanding the metabolic pathway that lead to a change in metal status. This study will investigate the isotopic fractionation of iron, copper and zinc on binding with proteins in simple to complex biological systems, and how this relates to metal cell metabolism, with the key aim of establishing a robust reference frame for future investigations of isotope biochemistry.


**Keywords:** Isotope geochemistry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SNETP strengthening to consolidate collaboration within and beyond the nuclear sector' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

SNETP  is an European technology platform, founded in 2007 as a stakeholder forum recognised by the European commission to act as a key actor in driving innovation, knowledge transfer and European competitiveness. Its main role is develop research and innovation agendas and roadmaps for action at EU and national level to be supported by both private and public funding. It mobilises various stakeholders to deliver on agreed priorities and share information across the EU. SNETPs is focused on nuclear fission technologies, but it also fosters networking opportunities and international cooperation in order to address cross-sectorial challenges.SNETP has a mature structure reflecting these three strategic themes in its three pillars: NUGENIA, ESNII and NC2I which have well-established programs and governance (thanks to dedicated EC funded projects)  for succeeding in their missions:The aim of SNETP-FORWARD project is to help the association consolidating its structure, strengthening it’s position in the Set-plan and among the European ETIPs, enhancing it’s ability to interact with the European and International associations and organisation and last but not least to be engaged in the innovation world by boosting the innovation capacities of its members.


**Keywords:** nuclear, sustainable, innovation, platform, collaboration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a Soft-Copy Reading Environment for Digital Mammography in Breast Cancer Screening' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The lack of an adequate soft-copy reading environment is a major technological obstacle hindering the transition to digital mammography in Europe's breast cancer screening programmes. A Soft-Copy REading ENvironment (SCREEN) that can replace film-based reading in screening programmes will be developed and its system design constraints specified. Problems posed by current digital image display technologies and by the strong requirements on diagnostic throughput and quality in screening mammography need to be solved. The research and development will focus on computer-aided lesion interpretation; new applications of computer-aided detection; digital image standardisation; intelligent computer-aided workflow management; computer-assisted training and in-service monitoring of radiologists; lesion data-mining in image databases; and workstation design. The resulting prototype SCREEN system will enable an experienced screening radiologist to read one hundred cases an hour. The lack of an adequate soft-copy reading environment is a major technological obstacle hindering the transition to digital mammography in Europe's breast cancer screening programmes. A Soft-Copy REading ENvironment (SCREEN) that can replace film-based reading in screening programmes will be developed and its system design constraints specified. Problems posed by current digital image display technologies and by the strong requirements on diagnostic throughput and quality in screening mammography need to be solved. The research and development will focus on computer-aided lesion interpretation; new applications of computer-aided detection; digital image standardisation; intelligent computer-aided workflow management; computer-assisted training and in-service monitoring of radiologists; lesion data-mining in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The romanization of Europe and its impact on Iron Age horse breeding and ritual practices: a DNA assessment in Gaul'.

assistant: **Objectives**

Horses represent one of the animal species that most impacted human history. They armed past societies with fast mobility while they provided new farming companions and crucial allies at war. As one of the most prominent symbols of wealth and prestige, horses were also commonly integrated in a variety of belief systems. This was the case for protohistoric Gaul from 500 BCE, where horses became increasingly associated with ritual practices, ranging from simple isolated deposits, to funerary rituals in connection with humans and chariots, and sacrificial sanctuaries. Current understanding of these horse-centered practices, and how they were transformed under Roman influence from the 1st century CE is, however, extremely limited for the lack of relevant textual historical sources. The GaRlic project proposes to combine state-of-the-art methodologies at the forefront of biomolecular archaeology to gain fine-grained resolution into ritual and breeding practices in protohistoric Gaulish horses, and follow their changes during the Romanisation process. Our core hypotheses are that specific animal types were bred across Gaul and selected for ritual practices, and that non-local horse resources were increasingly integrated during the Roman Period, ultimately reshaping both breeding and ritual practices. GaRlic builds on the availability of an exceptional archeological collection of protohistoric and Roman horse assemblages in Gaul and involves internationally recognised experts in zooarchaeology, ancient DNA and statistical genomics. It will investigate, for the first time, the horse bloodlines and the embodiment of social norms underlying Gaulish ritual practices and will reveal how the rise of the Roman Empire transformed such practices and, more generally, the pre-existing Ir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Characterization of the role of DNA methylation, hydroxymethylation and TET proteins in progesterone-mediated signaling in breast cancer cells' (HydroxyMethylation) targeting Seventh Framework.

assistant: **Abstract**

Hormone-dependent cancers affect millions of people worldwide and are a great burden to society, both financially and in terms of healthcare resources. The steroid hormone progesterone plays critical roles in a variety of physiological functions as well as in the carcinogenesis of hormone-dependent cancers including breast and endometrial cancers. Progesterone regulates gene expression through histone modifications and chromatin remodeling. However, the role played by DNA methylation in this context has not been determined. DNA methylation (5-methylcytosine) generally represses gene  transcription via methyl-binding proteins. Changes in DNA methylation levels are observed in carcinogenesis as well as in the dynamic regulation of genes which rapidly respond to stimuli. Ten-eleven translocation (TET) proteins hydroxylate the 5-methylcytosine during the demethylation process synthesizing 5-hydroxymethylcytosine (5hmC). 5hmC inhibits the interactions of methyl-binding proteins and can influence both long- and short-term regulation of gene transcription. The goal of this proposal is to identify DNA methylation and hydroxymethylation changes induced by progesterone in breast cancer cells. We will use hMeDIP-sequencing and combined glycosylation restriction analysis to measure the differential levels of 5-methylcytosine and 5-hydroxymethylcytosine marks. Furthermore, we propose to characterize the role of TET proteins in progesterone-mediated signaling. To this end, we plan to analyze gene expression and DNA methylation/hydroxymethylation changes in hormone-treated cells in the presence and absence of TET proteins. In addition, we will investigate TET binding in untreated and hormone-treated cells by ChIP assay. The outcome of this project will clarify the biological functions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'How to build a brain? Engineering molecular systems for mechanosensation and -protection in neurons' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mechanical forces are ubiquitous signals that provide critical and dynamic information about the environments around cells and organisms. Signals about touch, sound, and movements are transmitted to specialized mechanoreceptors but also deform the neuronal cytoskeleton of the central nervous system, particularly when strong forces are involved. Although failures to sense and cope with stresses are linked to human diseases including peripheral neuropathies and dementias, little is known about the connections between biomechanics and disease. A major reason for this gap is the technical challenge of detecting forces and deformations within a living cell or organism. Given the poor prognosis associated with neurodegenerative diseases, spinal cord injury and neuropathies, there is a strong need to develop a better understanding of neuronal mechanics. In the proposed work, we will define the changes in protein mechanics that contribute to pathological transformations in mechanosensation and mechanoprotection by developing a systems-level understanding of these processes in Caenorhabditis elegans. My lab will exploit our expertise in force application using microfluidic devices and state-of-the-art imaging to visualize mechanical forces in live cells during mechanosensation (Aim 1). We will integrate our observations with mathematical modeling to yield insight into how changes in material properties influence cell shape and physiology during aging of an organism (Aim 2). Over the long term, we will develop new strategies to limit mechanical damage in aging neurons using small protein chaperones and design a prosthetic optogenetic synaptic-transmission system to maintain neuronal signaling in diseased conditions (Aim 3). Broadly, I envision that the knowledge and tools designe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Enabling Interlaminar Fracture Testing of MULTIdirectional composite LAMinates for safe and efficient structures'.

assistant: **Objectives**

This project aims at solving long-standing problems affecting the characterisation of interlaminar properties of high-performance fibre reinforced polymer matrix composites. For these materials, interlaminar fracture, known as delamination, represents one of the most critical damage mechanisms. Standard procedures to characterise interlaminar fracture toughness exist, but their scope is restricted to use with unidirectional specimens, in which delamination is propagated along the fibre direction. On the other hand, real components and structures are made using multidirecitonal laminates, where delamination may appear at any interface and propagate in any direction; under such condition, interlaminar fracture toughness may be different from that obtained in standard tests. This results in uncertainties in structural design, and thus to oversized, inefficient structures. Until now, problems caused by elastic couplings, residual thermal stresses and delamination migration have prevented an effective interlaminar characterisation for multidirectional laminates. Recently, however, a new class of delamination specimens (Fully-Uncoupled Multi-Directional, FUMD) eliminating elastic couplings and reducing problems related to residual stresses has been proposed; also, new insight on the migration phenomenon has emerged. These developments open new possibilities. This project will combine the experience of the participating organisations on delamination migration and that of the researcher on FUMD specimens to explore these possibilities and achieve, for the first time, an effective, problem-free, characterisation of interlaminar fracture in multidirectional laminates. Possibly, this will contribute towards the creation of standard procedures, with an impact on the composite indus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tactical Instrumental Deconfliction And in flight Resolution' (TINDAiR) targeting Horizon 2020.

assistant: **Abstract**

TINDAiR VLD is meant to demonstrate the safe integration of UAM as additional airspace user.  The results of the VLD will help to refine the safety, performance, standardisation and regulatory requirements to enable UAM. The VLD will include the execution of flight demonstrations in accordance with the safety conditions. Four  mission/flights will take place with different operating methods, in coordination with all the relevant partners, and using more VTOL platforms carrying human passengers and medical equipment to simulate the variety of possible U-Space users in the near future. The demonstration flights will also include vehicles with full autonomous capabilities for automated safe procedures as well as helicopters.Flight demonstrations will address mainly the point defined as “mandated” for U-Space 3 requirements,  the Tactical Conflict Resolution and emergency landing with a focus on the pre flight checks for possible conflicts in strategic phase and in-flight checks for enabling each single VTOL operating in that airspace to rely on a DAA (detect and avoid) service providing instructions to aircraft to change their speed, level or heading as needed or force emergency landing to pre-identified vertiports in urban area.The ultimate objective of this very large scale demonstration (VLD) project is to deliver strategic and innovative technologies that can drive competitiveness and UAM growth using an impact-oriented approach and demonstrate the safe integration of UAM aircraft as additional airspace users.  The results of the TINDAiR project will help to:•refine the safety, performance, standardisation and regulatory requirements to enable UAM with specific focus on U-space U3 services identified in the U-space Blueprint and refined by CORUS, and,•unlock new and en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Support towards the Europe PMC initiative – Contribution for 2013' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The proposed action will support the European Research Council (ERC) in the implementation of its Open Access policy for projects funded in the Life Sciences domain. . The proposed project aims to fulfil the following four main objectives:to enable ERC funded researchers to use Europe PMC as a repository for their manuscripts, providing easy accessibility and wide visibility;to increase the visibility of the ERC as a funder of cutting-edge research by providing a clearly visible link between the publications emanating from ERC funded projects and the associated grants;to raise awareness - among and beyond the community of ERC funded researchers - of the ERC's commitment to support Open Access of scientific publications;to contribute to the effective dissemination of research results.A grant of €90,000 is requested to support these activities.