RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a multimodal toolbox to ensure a fast and reliable diagnosis of consciousness disorders' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

DoCBox aims to develop a new toolbox of fast and easy-to-implement behavioural, neuroimaging and neurophysiological assessments to accurately assess and diagnose patients suffering from a disorder of consciousness (DoC), allowing for a more comprehensive examination and better management of this vulnerable population. This toolbox will respond to the society needs regarding the evaluation of patients with DoC as it appropriately responds to the rigid time constraints of clinical settings, which are one of the biggest limitations for an accurate diagnosis. This project aims to enhance interdisciplinary research on DoC via an exchange of knowledge and international scientific cooperation to translate and validate the tools (e.g., behavioral scales, pipelines) that will be included in this toolbox. This collaboration between the partners underpins the credibility and feasibility of three research objectives:1) Provide new bedside assessment tools to refine and optimize the detection of consciousness signs in post-comatose patients; 2) Identify the most accurate neurophysiological and neuroimaging biomarkers of consciousness states and develop novel easy-to-use software to implement these analyses in clinical settings; 3) Engage informal and formal caregivers in the diagnosis of DoC patients.This will ultimately result in guidelines and policy recommendations for improvement of DoC patients’ diagnosis and thus care. The proposed exchange program aims to bring together a large international and interdisciplinary consortium of 17 partners (EU and non-EU countries) including researchers and other professionals with all necessary skills, permitting to tackle the challenges faced by professionals when studying and caring for DoC patients. The benefits for Europe are the intersec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MICSED - Molecular Interactions in Complex Systems' (MICSED) targeting Seventh Framework.

assistant: **Abstract**

This proposal brings together Procter and Gamble (the world’s largest producer of packaged consumer goods), with Durham University (a world top-50 science faculty in a research-intensive university) to train ESRs capable of bringing market-changing research innovations to a wide range of product areas.  Modern consumer products have to be highly sophisticated to achieve the performance levels consumers demand, and often have to be significantly over-engineered to deliver acceptable levels of reliability and stability.  This can lead to significant sustainability issues.  Product innovations enabling the reduction of active ingredients, better performance with lower consumer energy consumption and lower post-usage waste will have significant impact.The simultaneous requirement for stability in storage and efficacy during usage requires product formulations to be remarkably complex multi-component multi-phase systems with many interacting molecular species.  Transformative innovations can therefore only be achieved through molecular-level insight, understanding and control.  The Molecular Interactions in Complex Systems European Industrial Doctorate (MICSED) will provide the theoretical tools, molecular scale experimental probes and mechanistic understanding required to achieve real insight and predictive ability.  The toolkits it provides will enable sustainable innovations in Hygiene, Laundry and Personal Care products.  The new insights into underlying molecular interactions and the capability to quantitatively predict how systems behave have potential to enable disruptive innovation and paradigm-changing new sustainable technology platforms which can be reapplied well beyond P&G’s fast moving consumer market.MICSED will showcase Europe as a centre for industry-academi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'INnovative Actuation Concepts for Engine/Pylon/Wing Separation FLOw Control  (Design, Build and Wind Tunnel Test)' (INAFLOWT) targeting Horizon 2020.

assistant: **Abstract**

The objective of the INAFLOWT project is to use combinations of existing active flow control (AFC) concepts to generate a major advance in AFC aerodynamic efficiency and reliability. Steady suction in combination with oscillatory blowing will be combined using arrays of the no-moving parts SaOB actuator. Active boundary layer separation control concepts will be studied using numerical simulations, as well as with bench-top, simplified geometry and small scale wind tunnel testing. The most promising concept will be tested, integrated as real-scale prototypes in a large wind tunnel model representative of the ultra-high bypass ratio (UHBR) engine/pylon/wing/high-lift system configuration, already tested within AFLONEXT, at realistic Reynolds number, to prove results in near industrial environment. The INAFLOWT consortium consist of known experts with vast experience and extensive excellence record of collaborations in the areas of AFC, high-lift aerodynamic, wind tunnel testing and CFD simulations. These capabilities and features will guarantee the successful realization of the ambitious goals of the INAFLOWT project and will progress the proposed AFC configuration beyond the State-of-the-Art. The outputs are ambitious and innovative and will pave the way to operational use of UHBR engines in commercial aircraft which will provide significant operational benefits of future European aviation products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Immobilised PolyOxoMetalate Single Atom Catalysts', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The sustainable future of humankind will be possible through reducing greenhouse emissions, enabled by the conversion of greenhouse gases to useful fuels and feedstocks. In this proposal, I will develop cost-effective and efficient Immobilised PolyOxoMetalate Single Atom Catalysts (IPOMSACs) for the electro-conversion of CO2 and nitrate into green fuels. The structural motif consists of a catalytically active metal site (SAC) encased by a metal-oxide framework (POM), and immobilised onto a conductive nanostructured support. POMs offer unparalleled promise for catalytic materials due to their unmatched tuneability, structural variation, and redox capabilities. POM-SACs have been reported for many oxidation reactions. However, an efficient catalyst for the reductive conversion of CO2 and nitrate has not yet been realised. During the project, I will identify, synthesise and characterise a series of highly selective POM-SACs, followed by their immobilisation onto nanostructured supports for stability enhancement. In situ spectroelectrochemistry will be utilised to identify key mechanistic steps and uncover structure-activity relationships in these materials for the future development of electrocatalysts. This fellowship will enable a ground breaking path in the design and mechanistic understanding of highly efficient electrocatalysts. The project will enable the researchers to bring together previous knowledge and expertise with the host institution, whilst obtaining new knowledge in the fields of electrochemistry, materials science, and characterisation of advanced materials. The researcher will benefit from world leading facilities at ICN2, providing an ideal environment for AAS's development, in addition to guidance and training for transferable skills conducive to a beg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Exploring novel pathways governing immunity and leukemia by studying the genetic basis of human myeloid cell defects  - from genetics to gene therapy'.

assistant: **Objectives**

Genomic system biology approaches offer new aspects to understand the basis of diseases and to develop new therapeutic strategies. Here, we propose to study rare human variants of the immune system to provide novel explanations of mechanisms governing inflammation and leukemogenesis. Following a full circle of translational research, our group has previously defined several novel clinical entities and elucidated their molecular defects (Nat Med 2007, NEJM 2009). Further studies have highlighted the critical role of new pathways for general biological principles (Immunity 2005, Nat Gen 2007, Nat Med 2008). Finally, we have developed innovative gene and cell-based therapeutic strategies and tested their feasibility in clinical trials (JCO 2007, NEJM2009).The overall goal of ¿Explore¿ is to decipher novel pathways controlling myeloid cell function and leukemogenesis. The following specific aims are proposed:1. To elucidate genetic defects causing neutrophil disorders in children by homozygosity mapping and to perform functional studies in vitro and in vivo using relevant animal models2. To identify novel genes controlling endoplasmic reticulum cell function and the secretory pathway in myeloid cells by employing RNA-interference technology3. To define the role of novel factors involved in controlling the topology of the endoplasmic reticulum and ER-stress in murine model systems4. To study the role of HAX1 in hematopoisis and leukemogenesis using a new murine HAX1flox allele and to develop a clinical gene therapy approach for patients with severe congenital neutropenia due to HAX1-deficiencyThese studies will not only identify novel genetic factors controlling human immunity and leukemogenesis, but may ultimately impact on the development of novel therapeutic strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing compounds targeting DNA replication licensing complexes as anti-tumor agents' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cancer is a major clinical, societal and economic burden worldwide and development of novel anti-cancer therapies constitutes a major investment of public and private funds. Despite intense research over decades however, which has led to a much improved understanding of cancer biology, cancer treatment remains a challenge. This is to a large extent due to the genetic heterogeneity of cancer and the ability of cancer cells to escape treatment by constantly undergoing further genetic alterations. During our ERC funded work, we have shown that aberrations in the DNA replication licensing pathway may contribute to the genome plasticity of cancer cells, and appear a common feature of cancer cells. They may however also constitute an Achilles foot, as cancer cells appear more dependent on negative regulators of the licensing system for survival. Cancer cells may therefore be more sensitive than normal cells to compounds targeting this control (inhibition of untimely licensing). We have identified compounds which target the DNA replication licensing inhibitor Geminin. The proposed PoC study will enable us to:-assess the efficacy and specificity of the identified compounds in cells and preclinical models and study their mechanism of action.-investigate the potential use of these compounds for studying cell cycle processes. -assess whether the functional imaging approaches developed under the mother ERC project, which quantify protein-protein interactions within living cells, may constitute a powerful tool for in-cell analysis of novel lead compounds. The project thus aims to characterize, protect and commercialize novel putative anti-tumor agents as well as the in-cell methods developed for their characterization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cambridge Programme for International Research on Europe (CAPIRE): Proposal for an Early-Stage Research Training Project (EST) on the External Relations of the European Union.' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The proposed Cambridge Programme for International Research on Europe (CAPIRE) constitutes a structured program for advanced research training in Contemporary European Studies with a specific focus on the different aspects of the Ems External Relations; commercial, legal, diplomatic and security-related policies, their formulation, execution and democratic accountability. The project will provide multidisciplinary research training for 12 Marie-Curie Fellows from diverse European backgrounds.The Fellows will receive from 10 to 36 months of doctorate-level training with the aim of either (a) completing a 3-year PhD Degree at Cambridge University;(b) completing 10 months of focused research training as part of a doctorate degree course undertaken at another university;(c) concluding 10 months of post graduate training with the object of earning the Degree of MPhil in Contemporary European Studies and with the possibility of continuing to read for the PhD at Cambridge or another European university.The specific scientific and educational goals of the CAPIRE project are to enable a small group of promising young researchers (the Marie Curie Fellows) to develop the qualifications necessary to embark on a long-term research career; to enable them to link effectively to the wider European research community; and to equip them with the necessary complementary skills to disseminate their knowledge to a broad public audience. These goals will be accomplished through a combination of personal supervision and tutoring, a sequence of lectures and seminars in related foundation subjects, and a guided program of practical research within the CAPIRE Research Group and in collaboration with experienced Cambridge scholars. In addition, Fellows will attend courses and workshops on resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Industrial implementation of adaptive computational methods for turbulent flow and fluid-structure interaction'.

assistant: **Objectives**

The ERC StG project UNICON (Project ID 202984) was completed in July 2013. The goal of UNICON was to develop new adaptive finite element methods for computer simulation of fluid-structure interaction, in particular for problems involving turbulent flow. Simulation of turbulent flow is an outstanding computational challenge, where the UNICON project made significant progress beyond the state of the art. The scientific results of the UNICON project include a new theoretical and methodological framework, and a computer implementation of the methods as open source software, published as part of the FEniCS project, co-founded by the PI (Hoffman) in 2003. FEniCS is today a world leading open source software for computer simulation based on differential equations, with an estimated 50 000 downloads per year, and the PI today leads the PRACE Tier-0 project FEniCS-HPC, in which algorithms and software are developed for the most powerful supercomputers in Europe. Compared to competing simulation software, free as well as commercial, UNICON computational technology has proven to exhibit unique features with respect to accuracy and efficiency. The idea of this ERC PoC project is to commercialize the UNICON simulation technology. In particular, ADAPTIVE targets civil (non-military) industry, with a focus on subsonic fluid dynamics. The strategy is to deliver services and products tailored to each customer, from deliverance of a simulation result, to education and support for integration of the simulation tools in the workflow of a customer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovation Management Capacity Enhancement of SMEs in Saxony-Anhalt for the period 2019' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The general objective of the described actions is to contribute to smart growth in the European Union by increasing the efficiency and effectiveness of investments in research, development and innovation and by contributing to a better and more efficient connection of actors along the innovation chain.The specific action will deliver services designed to ""Enhance the Innovation management capacity of SMEs"" by providing indepth support services to SMEs. Furthermore, beneficiaries of the SME Instrument under Horizon 2020 will receive specific targeted assistance to support coaching assignments addressing specific innovation weaknesses.To achieve the above mentioned objectives bottlenecks to the creation of economic impact in companies benefiting from grants by Horizon2020's SME instrument will be identified and these bottlenecks with the help of capable coaches addressed. This service to beneficiaries of the SME instrument in the context of a giving project is called 'Key account management'. In addition the efficiency and effectiveness of innovation processes will be increased in small and medium sized enterprises with significant innovation activities that could potentially become beneficiaries of European support to research and innovation but would not have effective access to consulting services for innovation management. This service, provided independently from a specific innovation project and focussing on a company's innovation management system, is called 'Enhancing the innovation management capacity of SMEs'.Direct impact from the two actions will be a significantly enhanced growth and profitability of SMEs receiving the services as compared to a control group. Innovation processes will be conducted more efficient and more effectively.Indirect impact will ari
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Gaining insights into Enzymes Transition States: Superacid as new tool to design specific CAZymes inhibitors.'.

assistant: **Innovation**

Glycosciences study the structural and functional roles of carbohydrates in biology and have an increasing impact on many areas of our economy (health, food, natural resources). Carbohydrate Active enZymes (CAZymes), which catalyse the assembly (Glycosyl transferases, GTs) and breakdown (Glycosidases, GHs) of glycosidic linkage in carbohydrates, are essential to life, being involved in key cell functions. Their pharmacological modulation by means of selective CAZymes’ inhibitors can have multiple applications (e.g. antiviral TamifluTM, antidiabetic GlysetTM, molecular chaperone GalafoldTM). However, the design of inhibitors endowed of high selectivity is challenging, representing the major obstacle in discovering new potent and safe therapeutic agents targeting CAZymes. In this context, GLYCOMIMIC offers an innovative approach based on superacid chemistry to gain insights into CAZymes’ transition states (TS) and to help the design of specific inhibitors, paving the way for short-term impact on drug discovery! Superacid chemistry is only mastered by very few research groups in the world and is a European specificity of the Institute of Chemistry of Poitiers (IC2MP - UMR CNRS 7285 – France) and will be applied for the first time to glycosciences. With Univ. Barcelona (world leader in computer simulation of biological processes at atomic-electronic detail) acting as secondment, GLYCOMIMIC blends multidisciplinary states of the art research training in carbohydrate chemistry, superacids, low-temperature NMR analysis, DFT calculations, QM/MM dynamic simulation of enzymes and enzyme inhibition studies. It will provide a prolific fellow with an internationally competitive training, with the aim of advancing the career of an autonomous scientist in the EU and the next generatio