RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'AmyloAge: balancing proteostasis and metabolism in age-related muscular degeneration' in the context of a Horizon 2020 call.

assistant: **Objectives**

After the age of 30, our muscle strength declines by ~14% per decade. In up to 40% of the elderly, this decline culminates in sarcopenia (SP), critically low muscle mass, causing impaired mobility and longer hospitalizations. Muscle decline rates vary greatly between individuals due to genetic and environmental factors. Yet, our lack of insight into these factors impedes developing effective measures against SP. SP is clinically similar to inclusion body myositis (IBM), the most common myopathy in the elderly, and their molecular phenotypes are very similar. Preliminary data from my host lab, the Laboratory of Integrative Systems Physiology (LISP), show that high-fat diet induces amyloid-containing aggregates in the muscles of aging mice.  Such aggregates are hallmarks of muscle proteinopathies such as IBM. Hence, these diseases may be the pathological extremes of natural protein aggregation in the muscle. LISP recently described the protective, therapeutic role of activating mitochondrial stress responses in aggregation diseases. Activating these pathways prevents aggregate formation in cells, worms and transgenic Alzheimer’s mice. I thus hypothesize that mitochondrial dysfunction worsens the pathology of muscle aggregation diseases and SP. My project AmyloAge will explore natural aging in muscle in large, genetically diverse populations of worms, mice and humans. I will use my expertise in proteomics to study the evolution of muscle protein composition and find the genetic determinants associated with unhealthy protein aggregation and muscle decline. With my expertise in biostatistics, I will build an analysis pipeline to find the genes and molecular pathways responsible for protein aggregation and metabolic dysfunction in the muscle. AmyloAge will increase our knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated Interferometry and GNSS for Precision Survey' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

I²GPS will develop a novel, integrated approach to the use of synthetic aperture radar  interferometry (InSAR- data from GMES) and GNSS for use in the monitoring of subsidence, tectonic changes or other environmental hazards, which can only be identified by millimetric precision survey techniques.I²GPS proposes to deliver a fully integrated unit and end-to-end application for generating co-registered SAR interferometric and GNSS precision survey results by:•integrating the antenna of a GNSS receiver with a Compact Active Transponder  antenna to ensure millimetric co-registration and assure a coherent cross reference between the two precision surveying techniques, with unit verification confirmed at the mid term review ;•developing the integrated application processing and conduct field trials to confirm the effectiveness of the technique, to be reported at the final review;•preparing a business plan for exploiting the resulting product and reporting the results to the user community, thereby increasing the use of GNSS & GMES.The project responds to an identified user need; the Geological Survey of Slovenia needs an early warning system for  landslide hazards, such as that which “erased” a village and resulted in 8 casualties. The work plan captures the user requirement and encompasses field trials to validate the prototype unit and application processing development. Integration of a C-band CAT)with GNSS technology progresses beyond the state of the art but, because of the expertise of the team assembled, is sufficiently close to existing equipment & processing to give a high likelihood of success within the budget proposed. The partners believe that I²GPS will increase the market for both GNSS and GMES and are committed to the exploitation of the unit and application a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Reshaping labour force participation with Artificial Intelligence' (AI4LABOUR).

assistant: **Concept**

In the last decade, due to the tremendous progress of computing power, a new era which is called Industry 4.0 has been triggered. This new revolutionary progress in manufacturing systems will also create a huge impact on the socio-economic dynamics of society. Moreover, very recent pandemic conditions caused by COVID19 disease show that the modern labor force highly sensitive to the conditions and they are subject to change. Technologies based on data processing are changing not only the manufacturing standards but also the daily life of the people. Given that studies on future of work mentioned the possibility of automation of 30 percent of global working hours by 2030, it is important to take into account that Artificial Intelligence (AI) can take on the monotonous and repetitive aspects of works that are done by humans when some jobs will be automated. This may ensure focusing on more strategic or more analytical works. To offer a solution to this problem, this project proposal entitled “Reshaping labor force participation with Artificial Intelligence-AI4LABOUR” aims to predict which kind of new occupations will appear in near future and which kind of skills will be needed to get these new occupations. This can be achieved in this project in cooperation with different disciplines and sectors and in this way; the collaboration between different disciplines and sectors improve the impact of AI4LABOUR. Shortly, in the context of AI4LABOUR, required training to obtain these required skills would also be designed and planned. To achieve this goal, an innovative skill-based modeling and skill development methodology armed with AI techniques will be designed for the labor force. This novel methodology will be the building block of a web portal, which will serve as a recomme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional Role of the HLA-DR15 Haplotype in Multiple Sclerosis' (2007-2013).

assistant: **Innovation**

Multiple sclerosis (MS) is a prototypic CD4+ T cell-mediated autoimmune disease that damages the central nervous system. MS affects young adults and women twice as often as men. Neurological deficits cause substantial disability at an early age with high socioeconomic impact.Both a complex genetic trait and environmental factors are involved in MS etiology. Similar to other autoimmune diseases it has been known for almost 40 years that certain HLA-class II genes, in MS the two DR15 alleles DRB1*15:01 and DRB5*01:01, confer by far most of the genetic risk. Despite this clear role remarkably little is known about the functional contribution of these genes to MS pathogenesis, and this holds also true for all other T cell-mediated autoimmune diseases. It is assumed that the DR15 alleles present peptides from organ-specific self-proteins to T cells and select an autoreactive CD4+ T cell repertoire that can be activated by certain environmental triggers. Interestingly, the effects of the three known environmental risk factors in MS, Epstein Barr virus (EBV), low vitamin D3 and smoking, are all amplified by DR15.This core issue of research on autoimmune diseases and also MS, how disease-associated HLA-class II molecules contribute to disease development at the functional level, will be studied with state-of-the-art methodologies and a series of novel approaches. These will include in silico modeling approaches, studies of self-peptides, T cell receptor (TCR) repertoire and HLA-DR/peptide complexes, clonally expanded T cells from MS brain tissue and hypothesis-open methods such as combinatorial chemistry and tissue-derived cDNA libraries to identify target antigens. Finally, translational studies will investigate the relationship between the above aspects and MS disease heterog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Feasibility assessment of direct drive high speed turbo compressors for production oil free compressed air for medium size applications' to be submitted under Horizon 2020.

assistant: **Abstract**

Compressed air industry is undergoing a radical change where the share of environmentally friendly oil free air is rapidly increasing and energy efficient turbo compressors are replacing traditional screw compressors. Tamturbo Oy is a high tech start-up company bringing the turbo compressor technology to medium size oil free compressed air applications of 50 to 250 kW as the only European manufacturer which is speeding up the revolution of the 10 B€ compressed air industry.In the award winning Tamturbo direct drive design the turbo wheels of a two stage compressor are directly coupled to a high speed electric motor.  The main benefits of the turbo design over state-of-the-art dry screw compressors are 15 % lower electricity consumption over the 10-15 year life cycle, decreased operating, maintenance, waste management and overhaul costs due to minimum wear, and the benefit over other turbo designs is better capacity control under variable loads. Fast business growth is attempted by offering the compressors and related service packages under Tamturbo brand in Scandinavia and under Private Label or OEM contracts in other markets.  Medium size compressor manufacturers which do not have access to oil free technology today are seen as the most promising commercialization partners. However, extensive field testing of prototype compressors is needed before full commercialization of the technology. The objectives of the feasibility study is to acquire direct feedback from end users and potential Private Label and OEM partners as well as to identify European industrial field testing sites for prototype compressors. The Tamturbo business plan including marketing and IPR strategies will be refined accordingly. The actual field testing could be performed in a H2020 Phase 2 SME proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'agriculTurE wAste PyrOlysis and Thermocomposting for renewable energy in Sustainable agri-food sector' (TEAPOTS).

assistant: **Innovation**

TEAPOTS aims to give agri-food players an innovative integrated, modular, and flexible solution to meet local and seasonal energy demand through the valorisation of lignocellulosic and difficult to be treated agricultural waste while producing biochar. The first valorisation process will employ pyrolysis to extract heat from waste. Heat will be employed by an Organic Rankine Cycle to produce electric energy, which will be employed by a Dry Cooler & Oil-free AWC to cool down cold rooms for storing agri-food products. The second process will extract heat using a Compost Heat Recovery System to harness hot water from the oxidation of biomass while producing compost. Heat will be used to provide sanitary hot water. These technologies will be integrated in the TEAPOTS Integrated Solution, TIS, to demonstrate the feasibility of the entire process using all the modules to provide refrigeration. Biochar and compost will be used as plant biostimulants to increase yields and store carbon in soil improving the environmental footprint of the end-user. Feedstocks to be used in the TIS will be mixed to improve energy production and products’ quality.  Field and satellite data will be gathered to evaluate biomass growth, while the TIS operational data will be used to evaluate the environmental impact, through LCA analysis, and the overall functionality of the solution. Data will be integrated in a database which will allow the prediction of waste biomass production. This will be used by a Data Driven Decision Support System (DSS) to improve field and waste logistics, which will provide the means to keep the TIS up and running. The prediction system and the DSS will be integrated in the TEAPOTS Digital Platform, which will have an easy-to-use user interface to help end-users in the man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart Immune ProTcell: first-in-class allogeneic thymus empowered T cell therapy platform for fast and durable immune system reconstitution' under Horizon Europe.

assistant: **Concept**

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is used in immunodeficiencies & blood malignancies though costly, hard-to-access & linked to many severe complications. Smart Immune puts forth a high-profile solution to solve this gap: ProTcell platform supplies clinical-grade, allogeneic lymphoid progenitor cells produced in just 7 days ex-vivo. These are made into tolerant polyclonal mature T cells by the patients own thymus in a record <3 months (vs. 15-24 months naturally), & reducing complications since infused in our 1st patient (June 2020). With strong IP, orphan drug label secured & traction across eminent KOLs in >7 countries, we face a window opportunity. With the EICs support, we pursue the less attractive-to-VCs SCID indication, as part of our Series A, to become a front row T-cell therapy player, with future chimeric antigen receptor (CAR) therapies in mind. We project to treat >40k patients by 2030 & recover a ROI of 5,28 over our target Series A.


**Keywords:** Regenerative medicine,Allogeneic Therapies,CAR-T therapies,NK cells,CAR-T cells,Immunodeficiency,Immuno-oncology,Lymphoid progenitors,Cellular Therapies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cosmic Fireworks Première: Unravelling Enigmas of Type Ia Supernova Progenitor and Cosmology through Strong Lensing' under Horizon 2020.

assistant: **Concept**

The LENSNOVA project proposes a breakthrough both in cosmology and stellar physics, capitalising on 10 years of experience in the field of strong lensing time delays. Type Ia supernovae (SNe Ia) can now be watched on prime seats through strong lensing, where multiple images of the same SN appear at different times/locations around a foreground lens galaxy. After the first SN appears, the next SN occurrence (of the same SN event) can be predicted and observed in its entirety for the first time in history and with unprecedented temporal sampling. Observations of the beginning of SN explosions are key to revealing SN progenitors, that have been under debate for decades. Strongly lensed SNe Ia also allow an independent measurement of the Hubble constant (H0) that sets the cosmic expansion rate. The independent measurement is important to ascertain the possible need of new physics beyond the standard cosmological model, given the tensions in current H0 measurements. Capitalising on the PI’s expertise in strong lensing and success in predicting the reappearance of the first strongly lensed core-collapse SN, the objectives of LENSNOVA are to (1) place the best constraints on SNe Ia progenitors, and (2) pioneer the use of strongly lensed SNe Ia as a new cosmological probe. This will shed light on the natures of SNe Ia progenitors and dark energy, two of the greatest puzzles in the present era.The advent of the Large Synoptic Survey Telescope and the Euclid mission makes LENSNOVA particularly timely for building the first sample of ~5 strongly lensed SNe Ia. Accurate predictions of the time delays in lensed SNe Ia will allow multiwavelength observations of the reappearances of SNe, especially in the earliest days of explosion for the first time, to place the best constraints on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'In vivo metabolic imaging at low magnetic field' (LF13CMRI).

assistant: **Concept**

Magnetic resonance imaging (MRI) is an excellent technique for medical diagnosis. Nonetheless, people from rural areas and low-income countries cannot access MRI due to its high associated cost. In recent years, low-field MRI has emerged as a potential solution to increase access to MRI, but at the cost of reduced signal sensitivity. This is a limiting factor in terms of resolution, traceable quantities of metabolites, and early detection of tumor tissue.In this context, hyperpolarization (HP) has emerged as the most promising technique to compensate for the sensitivity losses at low magnetic fields. HP can enhance signal intensity by >10,000 times, providing enough signal to image even species at low concentrations, such as metabolites internalized by cancer cells. Here, the first in vivo metabolic imaging methodology with hyperpolarization at low magnetic fields is proposed. The project involves the development of 1H and HP 13C MRI at low field, the study of enzymatic conversion from HP pyruvate to other metabolites, and in vivo metabolic tumor imaging in mice. Para-hydrogen-induced polarization (PHIP) will be used to generate the HP contrast agent. PHIP offers several advantages, including low costs, low instrumentation demands, rapid high-throughput, and scalable production of HP agents in the liquid state.The combination of low-field MRI with PHIP 13C has the potential to provide a method for early cancer detection in a low-cost scanner.


**Keywords:** MRI, NMR, Hyperpolarization,13C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Structural and Functional Architectures of Multi-Kingdom Microbial Consortia Colonizing Plant Roots' under Horizon 2020.

assistant: **Concept**

The roots of healthy plants are colonized by a rich diversity of microbes, forming multi-kingdom microbial consortia that impact plant productivity. Despite the expected high connectivity between root microbiota members, our understanding of microbe-microbe interactions in structuring microbial networks in plant roots as well as their functional impact on plant growth remains poorly understood. Based on recent findings in my group, I propose a conceptual framework aiming at a functional understanding the holo-plant microbiome, where microbial interactions play an integral role in structuring root-associated microbial communities and maintaining microbiota balance and plant health. By profiling three independently-evolved microbial classes (bacteria, fungi, oomycetes) in the roots of natural Arabidopsis thaliana populations across Europe and establishing corresponding reference culture collections for subsequent reconstitution of the plant microbiota in vitro, I will define fundamental mechanisms underlying the structure and functions of the plant microbiota. I will generate and utilize extensive microbial genome resources for the interpretation of metatranscriptome profiles of multi-kingdom synthetic communities during root colonization. This will contribute to a transition from binary plant-microbe to community-level molecular investigations. Finally, using a genetically tractable tripartite interaction model between the non mycorrhizal plant A. thaliana, a beneficial fungal root endophyte and a rhizobacterium, I propose to functionally dissect the molecular basis of beneficial multitrophic plant-microbe interactions by identifying microbial genes that are essential for both microbe-microbe and microbe-host interactions.My hypothesis-driven research applies innovative