RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'bioMARkers and molecular tumor classification for non-genotoxic CARcinogenesis' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

MARCAR aims to establish reliable early markers and molecular classification of tumors in non genotoxic carcinogenesis, applying a mechanism-based approach. Benefits are improved drug safety, more efficient drug development, and progress with 3 R issues. MARCAR focuses on rodent liver, the major target organ of non-genotoxic carcinogens (NGC). However, this approach will facilitate predictions for other organs. Innovative industry-relevant experimental models will be developed: (i) Transgenic mice nulled orhumanized for NGC-responsive nuclear receptors, (ii) transgenic mice excreting marker proteins in urine, including oxidative stress reporter mice to monitor ROS production, (iii) transgenic mice allowing in vivo bioirnaging of preneoplastic lesions (PNL) and tumors, and (iv) primary cultures of human/rodent hepatocytes and their co-cultivation with mesenchymal cells which modulate carcinogenesis by NGC. In these systems, novel molecular technologies will be used for profiling thegenome, epigenome, transcriptome and proteome/phosphoproteome to provide global molecularsignatures of NGC-induced signalling. These complementary technologies in conjunction withstandardized data management and advanced marker identification algorithms will lead to molecular classification of tumors and PNL, and identify predictive molecular signatures of spontaneous vs drug induced tumors. Biomarker panels indicating the mechanisms of GC action will be derived and translated into assay systems. The validity, predictivity and robustness of biornarkers will be tested in collaboration with EFPIA, employing well—characterized pre—climcal models. For clinical translation humanized/human systems and materials from clinical trials will be tested for NGC effects on homologues of rodent biomarkers. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Experimental Epidemiology in Ant Societies' (EPIDEMIC), addressing dissemination and exploitation.

assistant: **Impact**

The risks and impact of disease are exacerbated in social organisms, which live in dense groups wherein pathogens can rapidly propagate. Theoretical epidemiology predicts that disease dynamics will depend in large part on a group's social interaction network, but empirical data are scarce. Experimental epidemiology is currently hampered by a lack of study systems that would enable a rigorous investigation of the causal link between network structure and disease transmission. I will tackle this question using a novel system, the clonal raider ant, a social insect whose unique biology affords unparalleled control over the main aspects of colony composition that are thought to modulate social network structure, and therefore, disease transmission. My approach will combine cutting-edge automated techniques for behavioral tracking with molecular tools, and develop new methods to monitor transmission in real time. In a first step, I will create empirical networks that are theoretically predicted to vary in transmission risk and map individual immune function onto these networks, to measure the prophylactic network properties that might reduce disease transmission. Second, I will test if experimental increases in immune activity induce changes in behavior that are relevant for disease transmission, to measure inducible network properties. Finally, I will inoculate colonies with nematodes and quantify infection propagation in real time. This will allow me to compare various types of social networks (healthy, immune-activated, infected), to probe the link between behavior and immunity, and to experimentally test predictions from theoretical epidemiology. This project takes an integrative approach—from individual immunity to collective behavior—to uncover the properties of social
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The medieval plagues: ecology, transmission modalities and routes of the infections' under Seventh Framework.

assistant: **Concept**

The history of late medieval and early modern Europe was deeply affected by epidemics of plague that repeatedly broke out until 1750 AD and caused devastation and death with severe social, political and economic consequences. For decades, historians and scientists have been interested in the ancient pestilences and disputed their origin and epidemiology. One century ago, Yersinia pestis was identified as the causative agent of the current-day pandemic. Only some months ago the MedPlag team conclusively established (Haensch et al. 2010) that this bacterium was responsible for the Black Death (1346-1353 AD) and that two distinct variants of Y. pestis were simultaneously circulating through Europe during this pandemic. These results raise questions concerning the historic Y. pestis strains, their geographical origin, and whether they might have re-circulated in Europe over four centuries or were constantly reintroduced from elsewhere. Other open questions concern the routes of transmission of the medieval plagues and the role played by trade and pilgrimages in their dissemination, the mechanisms of transmission and the implication of wild and anthropochorous fauna, and the interplay between climatic conditions and plague dynamics. In addition, whether the reason for the disappearance of plague from Europe 250 years ago was due to improved hygiene or to genetic or environmental change remains unknown. Finally, while historians and scientists have speculated on the microbe responsible for the Justinian plague (541-542 AD) molecular evidence is still lacking. In this proposal, I outline the methodology by which I will answer these major questions with an inter-domain investigation involving ancient DNA, climatology, ecology, and history. The results of this work will not only
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Low-Power Artificial Intelligence Framework based on Vector Symbolic Architectures' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Artificial Neural Networks (ANNs) form the main approach in Artificial Intelligence (AI). They have two major drawbacks, however: (1) ANNs require significant computational resources; (2) they lack transparency. These challenges restrict the widespread application of AI in daily life. The required resources prevent the use of ANNs on resource-constrained devices and the lack of transparency limits their adoption in many areas where transparency is critical. This action will address these challenges via development of Vector Symbolic Architectures (VSAs): a transparent, bio-inspired framework for AI. With respect to the 1st challenge, VSAs have the potential to become a computational paradigm for emerging low-power computing hardware with huge potential for implementing AI algorithms. With respect to the 2nd challenge, VSAs are a promising framework for opening the black box of ANNs due to their predictable statistical properties. It is expected that VSAs will allow analytical characterization of a class of Recurrent ANNs. The overall research aim of this action is to improve the understanding of computing principles in high-dimensional spaces with VSAs, and to advance the theory and design principles of simple AI algorithms implementable on emerging low-power computing hardware. The research aim comprises five research objectives. These are relevant to H2020 Work Programme since this action has much potential with respect to the “market creating innovation” and “digitising and transforming industry” aspects of the Programme. The mechanisms for achieving the objectives include both theoretical development and applied investigations. The methodological approach combines the current skills of the applicant with those acquired during this action. The applicant will develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nonlocal integrable equations: blow-up phenomena and beyond' (NIEB-PHAB) targeting Horizon Europe.

assistant: **Abstract**

I will carry out this fellowship at the University of Oslo, under the supervision of Professor Kenneth Karlsen at the Department of Mathematics.The project is devoted to study existence and blow-up properties of the solutions of initial value problems (IVPs) for nonlocal nonlinear integrable PDEs. Nonlocal integrable equations were introduced by M. Ablowitz and Z. Musslimani in 2013 and have become a hot topic in the theory of integrable systems. By applying inverse scattering transform (IST) method it was shown that soliton solutions of nonlocal equations blow-up in isolated points in x,t plane. Therefore the natural question is to study the existence and blow-up properties of the general IVPs for such equations. To this end we will use the mixture of the IST method and PDE techniques. The former will be used for predicting the presence and the form of the blow-up of the solution, while the PDE approaches will be used for describing the blow-up of the solution of the general IVP and for finding a suitable concept of a weak solution, which exists even after the collapse.Also by the IST method it was shown that apart from zeros, which correspond to solitons, the associated to the initial data spectral functions have the new type of singularities. These singularities correspond to the winding of the argument of the spectral function and play a significant role in long-time asymptotic behavior of the solutions ? they are responsible for a transition between qualitatively different asymptotic zones in x,t plane. It is a challenging open problem to describe analytically the nonlinear effects corresponding to these new singularities and in the framework of the project we are going to investigate this phenomena numerically.The fellowship will allow me to expand my skills in PD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Technological Determinants of Entry through Diversification' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and contentThe question I want to address is: why do firms diversify in particular directions? This question involves a quite different approach from the ones in the literature. It assumes that firms do not diversify at random, but they diversify with larger probability in particular industries or product groups. I am interested in studying the idiosyncratic, firm-specific determinants, especially those connected to the technology used by the firms. The theoretical framework, which will justify the empirical analysis assumes that firms are heterogeneous. The firm can be interpreted as a set of competencies; together, they constitute its knowledge base, which represents the pool of resources available to the firm to perform its normal activities.We can identify three main groups of competencies:(1) technological capabilities,(2) internal capabilities, and(3) external capabilities.I want to concentrate on the technological components of the knowledge base and on their relevance in determining the directions of diversification. If the basic intuition were correct, we would expect to find that the knowledge bases of the firms entering the same industry are closely related. Therefore an econometric analysis could give us an insight on the technological knowledge that the firms in a specific industry must posses in a specific period (because they better conform to that specific industry characteristics in that specific period) and how they change. This requires two levels of analysis: one related to the firm technological base and one related to its production activity. I will need data for both, but for the first I also need a characterisation. This requires the identification of the areas of research in which the firm is engaged. Since it is not possible
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Can human embryo-released extracellular vesicles govern endometrial receptivity and inform on vanguard embryo diagnostics and fertility therapeutics?' (CERVINO).

assistant: **Innovation**

Preimplantation Genetic Screening (PGS) based on high-throughput embryo genome sequencing is currently utilised in In Vitro Fertilisation (IVF) to select for euploid embryos prior to uterine transfer in order to increase implantation potential. The methodology for the acquisition of genetic material is controversial, as the invasive embryo biopsy required for PGS may compromise embryo quality. Moreover its long-term biosafety has not been evaluated. Consequently, the development of non-invasive methods to screen out aneuploid embryos is paramount. The host research group recently first reported that human IVF embryos release extracellular vesicles (EVs) and demonstrated their uptake by primary endometrial cells (ECs). Our pilot analysis of the embryo-derived EV transcriptome revealed an abundance of genes that may be involved in the establishment of endometrial receptivity. Additionally, our RNAseq on ECs, which had internalised human embryo-exported EVs, showed a gene-upregulation profile relevant to implantation. Collectively, our findings introduce a novel concept to the state-of-the-art whereby human embryos deliver a functional EV-transcriptomic cargo to ECs to mount an implantation response. Delineating the EV transcriptome, and studying the consequence of its delivery in ECs, potentiates mechanistic insight into the pathophysiology of implantation. The project will characterise for the first time the transcriptomic cargo of euploid and aneuploid human embryo-exported EVs and scrutinise the effect of its internalisation on endometrial function. This cutting-edge work may negate potentially harmful invasive embryo biopsies for PGS by instead utilising biomarkers in EVs – a ‘natural cell biopsy’. EV biomarkers could also inspire therapeutics to enhance endometrial r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The slide of Punishment. An anthropological study of Post-Modern prison governance' to be submitted under Seventh Framework.

assistant: **Abstract**

Developing an interdisciplinary approach between Criminology, Social control theories and Anthropology, the project contributes a new theoretical framework for the analysis of punitive transformation in Europe. It analyses mechanisms and devices of a new model of penal management in the spanish prison system and compares it to relevant data from german and european research projects. The new penal management model has been conceptualized by the researcher as Therapeutic governance. This concept serves to describe the institutional strategies, disciplinary actions and rhetoric orders through which the prison allows to legitimate a new punitive era. Assuming that prison governance is significant for society as a whole the research will analyse control technologies exerted in the prison spaces and how they slide into public dynamics through different agencies. Consecuently another new concept, the Punitive Agora, will be developed. This concept puts under discussion and theorizes three current tendencies of postmodern penality: the download of responsibility for crime control into the community, the emergence of a penal populism rhetoric and the discriminatory criminalization of specific groups. Comparing its findings with studies produced in Germany, Europe and beyond, the project will enable to take up important questions of contemporary governance. Thus, it will allow to consolidate the researcher’s career as an international specialist in the field of Anthropology and Criminology. He will develop and apply new tools for interdisciplinary and comparative analysis and increase his competitiveness in academia. The researcher’s capacity to stimulate collaborations between international departments and research groups will be reinforced. Finally, the project will allow to e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Setting up high-value sea cucumber chain in Europe through a new fishing gear with no environmental impact and advanced processing equipment' under Horizon 2020.

assistant: **Concept**

AURORA SEAFOOD is the Icelandic SME currently leading the incipient Sea Cucumber (SC) industry in Iceland —the leading country in the SC business in Europe. The seafood fishery and processing industries are claiming for long-term sustainable and efficient innovations that assure the economical profitability of business. Firstly, the high percentage of the costs of raw material, due to low availability of traditional species at sea, creates the need for species diversification. Europe still has huge potential to exploit other species highly valued in international markets. Secondly, the intensive manual labour in the production of seafood goods poses a risk. TOPBALAT represents an integrative approach to establish for the first time in Europe an advanced SC value chain comprising SC fisheries and processing industry. SC have a high commercial value, and global demand is increasing led by China, the first economy of the world. The innovation of TOPBALAT lies in the resource exploited, the SC-specificity of the technology, and the way our technology components set up a value chain for the whole business. Our approach tackles fishing, automated processing and distribution, and allows for other companies to tap on this market with the introduction of European processed dry SC at competitive prices in the Asian market. TOPBALAT’s specific SC technology saves costs: 20% less total costs due to increased manoeuvrability, reduced gear loss, increased catching efficiency (70%), reduced by-catches (5%), only 5% of meat discards in the processing, and 90% less distribution costs. AURORA will commercialise the final product (dried whole fully processed SC) and the technology to harvest and produce it. TOPBALAT’s product target users are the middle-upper class in China, and our techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HeatTANK – The cool way to store heat. Energy efficient solution for cooling telecommunication data centers' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The information and telecommunication sectors are responsible for up to 2% of the global green-house gas emissions. Data centres and telco sites run 24/7. The cooling system alone may account for up to 40% in average of the energy demands of a data centre, resulting in a significant cost factor to owners and operators, especially for telecommunication service providers. Our company, HeatVentors Ltd, invented and patented HeatTANK, an innovative solution that can be used to optimise cooling process by storing cooling energy in phase change materials (PCM) in a controlled and optimised way. Our solution will complement or even replace conventional compressor-based air conditioners for data centres. Our pilot project results showed that using HeatTANK reduces the cooling costs of a telecommunication site by 54% with 3,96 years ROI. The leading actors of telecommunication and energy sector expressed their interest to our solution, such as IBM, Vodafone, T-Systems from ICT industry as well as MVM and E.ON from the energy sectors. According to the pre-orders, we will step to the Hungarian market in 2019 Q2 and to the international market in 2019 Q4. Our talented group participated at several start-up competitions with success, for example, we are European winners of InnoEnergy PowerUp! competition in 2017. and won Special award at Women Start-up Competition Europe in London. Our company is accelerated by Climate-KIC and got investment from KIC InnoEnergy. This Phase 1 project will help us to carry out a feasibility study aiming to elaborate different use-cases and refining our business plan.