RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of photoswitchable ligands for the reversible and selective assembly with RNA'.

assistant: **Objectives**

The proposed project aims at the development of novel functional ligands whose association with ribonucleic acid (RNA) is reversibly activated by light. As several RNA forms are essential key elements in physiological processes, the control of their function or malfunction by the reversible binding of photoswitchable ligands possesses a great potential as a tool in anticancer, antiviral and antimicrobial therapy.  Surprisingly, this innovative approach towards a controlled reversible generation of RNA binders was mainly neglected in this highly topical research field. Hence, in this project photochromic hemi-indigo and fulgide derivatives are chosen as a platform for the design of photo-responsive RNA ligands, because i) they exhibit general features of RNA binders; ii) their structure can be reversibly modified by light, iii) the core structures are readily synthesized, and iii) the substitution pattern can be easily varied to enable fine-tuning of binding selectivity based on structure-activity relationships. In addition, conjugates that comprise two photoactive RNA-binding units will be obtained and studied because such bifunctional binders are expected to have very high affinity and selectivity toward RNA. An extensive library of derivatives will be synthesized and tested for their photocontrollable association with RNA. As a special method, real-time NMR-spectroscopic studies with direct irradiation of the sample inside a specifically designed spectrometer will be used to assess in detail the dynamics in the course of the photoinduced ligand–RNA interactions. Overall, it is anticipated that this systematic approach will enable the identification and development of lead structures for controllable RNA-targeting drugs with a great pharmacological potential. Moreover,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Rethinking Conscious Agency' (ReConAg).

assistant: **Innovation**

This project will investigate the nature, structure and significance of conscious agency along three related fronts.First, although philosophers have emphasized the importance of various aspects of consciousness for human agency, work on conscious agency within philosophy remains unsystematic. Cross-talk regarding the phenomena at issue hampers progress, as does a lack of significant attention to the richness of the phenomenology that accompanies human agency. In response, we will develop a new account of the nature and mechanistic underpinnings of agentive phenomenology.Second, although psychology’s recent progress in explaining agentive capacities – e.g., metacognition, cognitive control, attention, perception, decision-making, and motor acuity – is impressive, insights regarding the importance of consciousness for these capacities need to be made explicit, and leveraged to construct a next generation model of action control. In response, we will map the phenomenology of agency onto the structure and function of action control capacities, with special focus on three areas: the role of explicit knowledge and its signatures within consciousness, the function of phenomenal states for cognitive control resource allocation, and the relationships between conscious intentions and perceptual feedback.Third, we will deploy the tools of experimental philosophy – that is, the use of psychological methods to study philosophical questions – in two novel areas. First, we will complement and advance this project’s philosophical work by experimentally investigating agentive phenomenology. Second, we will explore the practical and moral significance of conscious agency, by determining what aspects of conscious agency drive commonsense moral thinking about responsibility for action.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PHYSICIAN AIDED RECONSTITUTION OF THE IMMUNE SYSTEM' (PARIS) targeting Seventh Framework.

assistant: **Abstract**

Unwanted immune responses to self-tissues and transplants have a major impact on human health and wealth. Their management has required long-term immunosuppressive drugs which penalise the whole immune system. The big challenge has been to understand how the individual is naturally tolerant to self, and to exploit this knowledge for treatments better targeted to the relevant antigens. Since 1980 the applicant’s laboratory  have, in rodent models, defined mechanisms of acquired tolerance, and used monoclonal  antibodies to transiently block lymphocyte function, or deplete  lymphocytes with the goal  of establishing  tolerance therapeutically.  This led to the discovery of ”infectious tolerance” where tolerance was shown to require  regulatory CD4+FoxP3+ T cells. Although efficacious in rodent models, equivalent blockading   antibodies for man, although available, have not been commercialised by the pharmaceutical industry.  To deplete lymphocytes in man, our laboratory has also developed the anti-CD52 monoclonal antibody, CAMPATH-1H. This was the first humanised therapeutic antibody (Alemtuzumab/Lemtrada) and is being  actively pursued for  multiple sclerosis and stem cell and organ transplantation.  Although lymphocyte depletion has clearly proven to be clinically useful, it has not, when used alone, permitted tolerance to transplanted organs or allowed for durable immune reprogramming in autoimmune disease.   This proposal seeks to understand how to build on the benefits of lymphocyte depletion with CAMPATH-1H,  and promote tolerance by exploiting tolerance–promoting mechanisms learned from our studies of  co-receptor/co-stimulation blockade. The novel approach taken by this project is to investigate and manipulate the reconstitution phase of lymphocyte recovery throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biogenesis of plant mitochondria' to be submitted under Fifth Framework.

assistant: **Abstract**

Postgraduate fellowships are available at the Departement de Biogenèse des mitochondries végétales" at the "Institut de Biologie Moléculaire des Plantes", a CNRS Institute in STRASBOURG (France). The host team is divided into four research groups with specific but interrelated interests.1) The first group (Dr A. DIETRICH) is interested in the mechanism of plant mitochondrial (mt) DNA repair and the enzymatic activities which are involved (glycosylases, endonucleases, ligases) .2) The group of Dr L. DROUARD is involved in the study of tRNA import into plant mitochondria, analyzing the basis of the specificity of this mechanism and the proteins of the outer membrane which are involved.3) A third group leaded by Dr J. GUALBERTO is studying the post-transcriptional modifications of mt mRNAs, an important step of gene expression in plant mitochondria. This includes the study of RNA editing, RNA binding proteins and the specific degradation of mt mRNAs induced by the polyadenylation of their 3 ' end.4) The last group (Dr G. BONNARD) is working on the biogenesis of c-type cytochromes. The mechanisms by which covalent ligation of heme to c-type apocytochromes occurs, is unique to plant mitochondria in eukaryotes and implicates a large number of proteins with the formation of multi-subunit complexes. The host will provide expertise in Molecular Biology, Biochemistry and Cell Biology of nucleic acids and proteins. Specific expertise is available in fractionation of plant mitochondria and analysis of sub-mitochondrial compartments, as well as in proteomics of these sub-compartments. Successful applicants will have a strong background in Molecular Biology and Biochemistry with a specific interest in the analysis of the structure and function of unidentified proteins. Further detail
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Macro-European forum on nanosciences and nanotechnology: from basis to applications' (NANOSCIENCESTECH).

assistant: **Innovation**

The nano" field encompasses scientific investigations and experimental processes relevant to structures and objects with at least one dimension much smaller than micrometers in size, down to single living cells, molecules, and atoms.It reveals a major interdisciplinary trend that clearly ranges from far upstream in physics, computation and biology, where the manipulation of single entities or of small collections of atoms is often referred to as nanosciences, to industry, where the continuing trend towards miniaturization is bringing down processes developed for microelectronics to the nanoscale, a domain referred to as nanotechnology.Nowadays, nanoscience technology is hardly taught in academic courses at universities and textbooks on the subject are still rare. A knowledge transfer from scientists currently engaged in the field towards younger ones is thus essential. The forum "NanoSciencesTech" is a coherent series of four schools and one conference in the field of nanosciences and nanotechnologies.The domains have been selected among those strongly impacted by the nanofield: condensed matter, optics and biology. The specific hot topics addressed by "NanoSciencesTech" are Nanophotonics, Self-organized Nanostructures, Nanomagnetism and Spintronics, Nanotubes, and Nanobio-Objects.We expect an attendance of about 400 young researchers from Europe and third countries. A coherent training will be provided by talented academic and industrial lecturers going from the basics in each field to the latest fundamental breakthroughs and most promising applications. In addition, dedicated sessions in the events will address intersections with the other schools and fields. For example, the bases of nano-instruments for probing nano-objects, nano-fabrication tools or computational n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Resource Minimized Casting by Development of a Modular Moulding Box System' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives and content In this proposal it is planned to develop a completely new type of mould. This type of mould is necessary for cast pieces with low batch sizes and a complicated surface like propeller blades and large components of paper machines. The main objectives are the complete replacement of mould sand and binder material, the reduction of the production time (app. 45 %) due to automated mould forming and the minimization of the environmental impact of casting debris, noise and dust. Although it is expected that much more than 10 % of the 2935 European foundries will use the project results in the future, this alone will lead to a market potential of app. 150 MECU and annual savings for each foundry of app. 500 kECU, not included the usage of partial project results like the new mould materials, the modular mould box and the robot for automated mould forming. The following steps are necessary to reach the project's goal: - The key factor of the whole development is the modular moulding box system. It will be accomplished by developing new environmentally save, recyclable mould material which will replace the patterns and the mould sand used today. Due to its modularity it easily and quickly can be adapted to any new dimensions and shape of casting pieces. - For the reduction of the production time and cost a robot system is developed for the mould forming, measurement and surface finishing. This robot system is programmed automatically and directly from CAD-data based on a knowledge-based, process-oriented programming system. This idea of sandless and patternless forming is a revolutionary development for the European foundry industry, in which the technical progress in the past was very slow. This project is very important for this industry, which is in st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Chemical Biology Approach to Understand the Release of Sonic Hedgehog' (CB-HEDGEHOG).

assistant: **Concept**

With 2,6 million new cases and 1,26 million deaths in 2012, cancer is the most important cause of death in the European Union (EU). The most common cancer forms are breast cancer, prostate cancer, bowel cancer and lung cancer. The Hedgehog pathway is one of the most important signalling pathways in tumourigenic processes and known to be involved in all of these four types of tumours that represent 52% of all cancer cases in the EU. Thereby, the key mediator of the signalling pathway in mammals is the protein Sonic Hedgehog (Shh). During its maturation, the morphogen Shh is post-translationally modified in the endoplasmic reticulum (e.g. autocatalytically cleaved and lipidated) and transported to the cell membrane. The subsequent release of the signalling fragment into the surrounding area of the expressing cell results in the formation of Shh multimers that are able to induce genes involved in the development of target cells. Due to its emerging impact on cancer development, several therapeutic approaches target the Shh pathway. Currently there are numerous ongoing clinical trials of corresponding drugs. In the context of the development of new cancer diagnostic and treatment approaches, it is of vital importance to fully understand the mechanisms of signalling pathways involved in the tumourigenic process in order to design effective therapies. However, crucial aspects of the Sonic Hedgehog pathway, particularly the mechanism of release of the Shh singalling complex from the expressing cell, remain to be elucidated, due to a lack of tools to investigate this multiply chemically modified protein complex. The aim of this project is to investigate the mechanism for release of Shh and the formation of well-defined active Shh multimers through a combination of organic synth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Brits' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Given that nowadays traffic demand exceeds existing road (and public transport) capacity at particular times ITS (Intelligent Transportation Systems) become an increasingly important tool for increasing the road capacity and make optimal use of it. However, the effects of ITS cannot be understood from existing travel demand theory. It can be concluded that the evaluation of ITS measures requires theories and models that describe both ITS and behavioural responses in a dynamic way, as opposed to the traditional models which describe travel behaviour as an equilibrium situation under average travel conditions. In addition, modelling the interaction between ITS and behaviour requires that apart from discrete choice behaviour also learning and adaptation behaviour and activity scheduling need to be included in traffic forecasting models.A better understanding of these behavioural aspects is crucial to apply ITS measures such that the full benefit in terms of avoiding congestion and maintaining accessibility is gained. In particular, if ITS is to be applied in a more strategic manner than today, a better understanding of behavioural responses is essential. Therefore, a Euro-workshop is proposed, with the aim of bringing together well-known researchers from various disciplines and creating a valid theoretical base for further research and development of forecasting tools.In addition, the workshop will be organised such that young researchers are able to learn from experts in the field and receive feedback on their own research work. The state of the art in describing and modelling responses to ITS, not only in the EU but also in the US and Japan, will be presented. The workshop will bring together leading scientists in the fields of ITS, travel demand modelling, microscopic t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Analysis and development of new insight into substitution of short car trips by cycling and walking' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

1- Presenting an overview of best practice for promoting cycling and walking instead of car-driving in cities by giving an overview of cycle friendly and pedestrian friendly infrastructure elements and other measures to promote cycling and walking, and by comparing measures to support cycling and walking, and by comparing measures to support cycling and walking implemented in cycle/pedestrian-minded and non-minded cities.2- Provide new knowledge on road users' modal choice for short trips in urban traffic by collecting and studying behavioural factors affecting transport behaviour (modal choice) and by collecting and studying daily travel patterns.3- Provide new knowledge about attitudes and behaviour leading to urban traffic accidents with two parties (car-cyclist and car-pedestrian) by in-depth interviews with those involved, as it is assumed that improving safety of cycling and walking could play an important role in the efforts of increasing their role in the urban modal split.4- Presenting general recommendations and guidelines to decision makers regarding directions for efforts to promote walking and cycling instead of short car trips in cities and for further initiatives in this field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Inclusive Growth Research Infrastructure Diffusion' (INGRID), addressing dissemination and exploitation.

assistant: **Impact**

Referring to the increasingly challenging EU2020-ambition of Inclusive Growth, the objectives of the InGRID project are to integrate and to innovate existing, but distributed European social sciences research infrastructures on ‘poverty and living conditions’ and ‘working conditions and vulnerability’ by improving the transnational data access, organising mutual knowledge exchange and improving methods and tools for comparative research. This integration will provide the related European scientific community with new and better opportunities to fulfil its key role in the development of evidence-based European policies for Inclusive Growth. In this regard specific attention is paid to a better measurement of related state policies, to high-performance statistical quality management, and to dissemination/outreach activities with the broader stakeholder community-of-interest, including European politics, civil society and statistical system.For this purpose key actors of the related European Research Area are coupled in the InGRID consortium, representing specific data infrastructures and cumulated know-how. Pan-European optimisation of the infrastructure is created by organising an open, harmonised high-performance on-site access with an extensive visiting grant system.Joint research activities are conducted for the innovation and optimisation of the infrastructure. Key issues tackled in this respect include: the multidimensionality as a standard for poverty research; the problem of hard-to-identify and hard-to-reach vulnerable groups in data collection; the improvement of longitudinal and regional poverty mapping; the survey technology for linking vulnerability in working conditions with economic change and employers’ behaviour; the harmonisation of classifying jobs and