RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Low temperature hydrogen production from second generation biomass'.

assistant: **Objectives**

The aim of HyTime is to deliver a bioprocess for decentral H2 production from 2nd generation biomass with a productivity of 1-10 kg H2/d. The novel strategy in HyTime is to employ thermophilic bacteria which have shown superior yields in H2 production from biomass in the previous FP6 IP HYVOLUTION.Biomass in HyTime is grass, straw, molasses or unsold organic goods from supermarkets. The biomass is fractionated and converted to H2 at high efficiency unique for thermophilic fermentation. Dedicated bioreactors and gas upgrading devices for biosystems will be constructed to increase productivity. The H2 production unit will be independent of external energy supply by applying anaerobic digestion to valorize residues. HyTime adds to the security of supply H2 from local sources and eradicates geopolitical dependence.HyTime builds on HYVOLUTION with 5 partners expanding their research efforts. Three new industrial partners, 2 of which are NEW-IG members, have joined this team with specialist expertise in 2nd  generation biomass fractionation and gastechnology. This way a pan-european critical mass in agro- and biotechnological research, the energy and hydrogen sector is assembled to enforce a breakthrough in bioH2 production. The participation of prominent specialists with interdisciplinary competences from academia (1 research institute and 2 universities) and industries (3 SMEs and 2 industries) warrants high scientific quality and rapid commercialization by exploitation of project results and reinforces the European Research Area in sustainable issues.The partners in HyTime have a complementary value in being developers or stake-holders for new market outlets or starting specialist enterprises stimulating new agro-industrial activities to boost the realization of H2 from re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EMERGING DISEASES IN A CHANGING EUROPEAN ENVIRONMENT' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

These last years, several vector-borne, parasitic or zoonotic diseases have (re)-emerged and spread in the European territory with major health, ecological, socio-economical and political consequences. Most of these outbreaks are linked to global and local changes resulting of climatic changes or activities of human populations. Europe must anticipate, prevent and control new emergences to avoid major societal and economical crisis (cf. SARS in Asia, West Nile in US). EDEN (Emerging Diseases in a changing European Environment) offers a unique opportunity to prepare for uncertainties about the future of the European environment and its impact on human health. EDEN's aim is to increase preparedness by developing and coordinating at European level a set of generic investigative methods, tools and skills within a common scientific framework (Landscapes, Vector and Parasite bionomics, Public Health, Animal Reservoirs). EDEN has therefore selected for study a range of diseases that are especially sensitive to environmental changes. Some of these diseases are already present in Europe (West Nile, Rodent-born, Tick-born, Leishmaniosis), others were present historically (Malaria) and so may re-emerge, whilst finally Rift Valley Fever is either on the fringes of Europe. EDEN integrates research between 42 leading institutes from 23 countries with the combined experience and skills to reach their common goals. EDEN is organised into a series of vertical Sub-Projects led and managed by an internationally recognised expert and linked by a series of Integrative Activities that include biodiversity monitoring, environmental change detection, disease modelling, remote sensing and image interpretation, information and communication. The proposed management structure, including a Scienti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering and reversing the consequences of mitochondrial DNA damage' to be submitted under Horizon 2020.

assistant: **Abstract**

Mitochondrial DNA (mtDNA) encodes several proteins playing key roles in bioenergetics. Pathological mutations of mtDNA can be inherited or may accumulate following treatment for viral infections or cancer. Furthermore, many organisms, including humans, accumulate significant mtDNA damage during their lifespan, and it is therefore possible that mtDNA mutations can promote the aging process.There are no effective treatments for most diseases caused by mtDNA mutation. An understanding of the cellular consequences of mtDNA damage is clearly imperative. Toward this goal, we use the budding yeast Saccharomyces cerevisiae as a cellular model of mitochondrial dysfunction. Genetic manipulation and biochemical study of this organism is easily achieved, and many proteins and processes important for mitochondrial biogenesis were first uncovered and best characterized using this experimental system. Importantly, current evidence suggests that processes required for survival of cells lacking a mitochondrial genome are widely conserved between yeast and other organisms, making likely the application of our findings to human health.We will study the repercussions of mtDNA damage by three different strategies. First, we will investigate the link between a conserved, nutrient-sensitive signalling pathway and the outcome of mtDNA loss, since much recent evidence points to modulation of such pathways as a potential approach to increase the fitness of cells with mtDNA damage. Second, we will explore the possibility that defects in cytosolic proteostasis are precipitated by mtDNA mutation. Third, we will apply the knowledge and concepts gained in S. cerevisiae to both candidate-based and unbiased searches for genes that determine the aftermath of severe mtDNA damage in human cells. Beyond th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synthetic Superantibodies – Bioinspired Engineering of Artificial Receptor Structures' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The project “Superantibodies” encompasses an interdisciplinary approach to accomplish the first instance of a biohybrid, yet fully synthetic three dimensional recognition element by converging the benefits of natural biorecognition with those of a synthetic approach. The bio-inspired concept is modelled on the antibody binding site whose binding capacity is the result of a defined three-dimensional structure in which loops of polypeptides cooperatively interact with the antigen through specific biomolecular interactions. The project implements a combination of modern biomolecular and bioanalytical techniques to identify peptides within these structures that are pivotal for the interaction with the antigen, and to use organic chemistry to synthetically mimic these peptides whilst maintaining their biological function. Affinity driven self-assembly between these peptides and their specific antigen is used to produce templates for a subsequent molecular imprinting process, resulting in a site-specific integration of peptides into the structural backbone of a molecularly imprinted polymer. It is hypothesised that it will be possible to rationally engineer recognition elements with tailored affinities by changing the number and the type of the embedded peptides to rationally create structures whose affinity can outperform that of naturally derived antibodies. This proposal is built on the expertises and scientific strengths of Dr Heiko Andresen while taking him in new directions. The multidisciplinary group of Dr Molly Stevens provides a fertile environment for the scientific and professional development of the applicant, and Imperial’s infrastructures and dedication to high-quality professional and personal career development strongly support Dr Andresen in reaching a posit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Controlled quantum effects and spin technology - from non-equilibrium physics to functional magnetics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The technology of the 20th century was dominated by a single material class: The semiconductors, whose properties can be tuned between those of metals and insulators   all of which describable by single-electron effects. In contrast, quantum magnets and strongly correlated electron systems offer a full palette of quantum mechanical many-electron states. CONQUEST aim to discover, understand and demonstrate control over such quantum states. A new experimental approach, building on established powerful laboratory and neutron scattering techniques combined with dynamical control-perturbations, will be developed to study correlated quantum effects in magnetic materials. The immediate goal is to open a new field of non-equilibrium and time dependent studies in solid state physics. The long-term vision is that the approach might nurture the materials of the 21st century.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Impacts of Greenland Ice Sheet melt on primary productivity and carbon cycling in Greenland coastal ecosystems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Due to recent anthropogenic climate warming, the Greenland Ice Sheet (GrIS) is melting at accelerating rates, increasing the freshwater content of the Arctic Ocean. Freshwater run-off from the GrIS influences circulation patterns and stratification of the water column and also introduces large fluxes of allochthonous organic and inorganic matter into the Greenland coastal environment, both of which have the potential to influence microbial carbon cycling. Changing patterns of circulation and stratification have the potential to effect water column mixing and thus nutrient supply to primary producers, while introduction of particles and suspended sediments can limit light availability to primary producers and provide increased surface area for bacterial activity. Recent studies also documented that GrIS melt water contains significant amounts of bioavailable organic carbon and nutrients, which could provide subsidies to the microbial community, but the impact is unknown. At present, studies have only quantified the effects of GrIS melt water on the physical and chemical environment of Greenland fjords, no studies have addressed the physicochemical effects of melt water and its allochthonous constituents on ecosystem carbon cycling, making it difficult to estimate how increased melting is altering the productivity regimes in coastal marine ecosystem around Greenland. Primary production is the base of the marine food web and supports commercial and sustenance fisheries along the Greenland coast. Melting of the GrIS is expected to intensify in the future. Thus, this project proposes a timely effort to determine the impact of GrIS melt water on productivity and carbon cycling in the Greenland coastal ecosystem, the results of which can be used by climate scientist and fisher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'CArbon-free Electricity by SEWGS: Advanced materials, Reactor and process design'.

assistant: **Innovation**

The proposed project CAESAR is building on work currently performed with the FP6 IP CACHET. One of the four pre combustion CO2 capture technologies that are being developed in CACHET is the Sorption Enhanced Water Gas Shift (SEWGS) process. The SEWGS process produces hot, high pressure H2 in a catalytic CO shift reactor with simultaneous adsorption of CO2 on a high temperature adsorbent. The system operates in a cyclic manner with steam for adsorbent regeneration.  The overall objective of proposed project CAESAR is the reduction of energy penalty and costs of the SEWGS CO2 capture process through optimization of sorbent materials, reactor- and process design. It is emphasized that with an optimized SEWGS process CO2 avoidance cost could be reduced to < € 15/ton CO2.    CAESAR takes into account the lessons learned in CACHET in order to bring the SEWGS process a big step closer to the market. To achieve this, CAESAR takes a necessary step back such that novel, more efficient CO2 sorbents with regeneration steam/CO2 ratios less 2 will be developed. This value is needed to bring the CO2 avoidance costs to about 15 €/ton. Heat integration and the use of sorbent coatings can further enhance the efficiency.    CAESAR will focus on the application of the optimized SEWGS process for pre combustion CO2 capture from natural gas. However the scope of application of SEWGS will be broadened to application in coal gas and industrial processes. A design for a pilot unit will be delivered for these applications.  There is a clear delimitation between CACHET and CAESAR. The emphasis in CACHET was placed on demonstrating the SEWGS process on a larger scale in a continuous, multi-bed SEWGS process demonstrator. CAESAR goes one step further in taking boundary conditions as to cost and eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Application of Virtual Anastylosis Techniques for Architectural Research' under Horizon 2020.

assistant: **Concept**

For anastylosis, historical data, temporal analyses and the current study of the element, are fundamental components that serve as a basis for decision making in CH reconstruction, restoration, management and dissemination. The ambitious purpose of AVATAR (Application of Virtual Anastylosis Techniques for Architectural Research) project is to contribute to anastylosis techniques with a new approach based on the latest technological fields.AVATAR intends to develop and optimize a set of procedures and tools to interpret the structural and conservation status in the architectural heritage, supporting decision-making and promoting the change of current practices towards preventive approaches to conservation, under the slogan “It is better to prevent than cure”.Thanks to our knowledge of the history of CH assets, it will be possible to prevent their deterioration in the future. These developments will contribute towards European excellence, enriching the society and helping in the cultural integration of the respected assets.


**Keywords:** Digital Twin, Geomatics, Geophysics,  Computer Vision, Machine Learning, Deep Learning, Cultural Heritage, Building Information Modelling, Virtual Reality, Augmented Reality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Platform economy through assemblages. The development of short-term rental markets in Athens, Greece and Berlin, Germany.' (DweLinks).

assistant: **Innovation**

DweLinks’ overarching goal is to explore the qualitative, geographical, and space-transformative characteristics of platform economy, and its development within complex, multi-leveled assemblages, in Athens, Greece and Berlin, Germany. More specifically, the project investigates the ways the emergence and establishment of digitally mediated, short-term renting (STR) markets, take place through i) the mobilisation and ii) the creation of ties and flows, among a variety of actors and networks. DweLinks’ major research hypothesis is that the development and establishment of STR activities is taking place through assemblages that employ, bring together, and mobilize human, material, and symbolic elements: urban and natural resources and assets (building stock, transport infrastructure, public spaces, sites of cultural and archeological interest, natural and cultural landscapes), labour, knowledge, services, historical meanings, and the notions of ‘sharing’ and ‘collaboration’. Through a qualitative methodology, heavily based upon assemblage thinking approaches, specifically Assemblage and Actor-Network Theories and the in-depth engagement with two study areas in each city, DweLinks will i) analyse and delineate the STR markets’ landscape in Athens and Berlin, through the exploration of their networks and actors, extent and limits, hybrid development, practices, role in socio-spatial transformations and differentiations, ii) enrich and inform ‘platform economy’ literature in the fields of urban studies, and social and economic geography, iii) inform policy agendas and regulatory frameworks and formulate policy directions,  through the in-depth understanding of the development of the STR activity and its articulation in local sites and networks.


**Keywords:** Platform Econo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Modelling and modulating diabetes-associated splicing dysregulation using human stem cell-derived islets'.

assistant: **Innovation**

Diabetes mellitus affects over 500 million people worldwide and arises from the progressive loss of functional insulin-producing beta cells. While transcriptional and epigenetic regulation of beta cells has been studied extensively, the role of alternative splicing, a fundamental mechanism that expands transcriptome and proteome diversity, remains poorly understood in this context. The BetaSpReg project aims to uncover how splicing regulators of the hnRNP family control beta cell development, function, and stress resilience, and to explore splice-switching oligonucleotides (SSOs) as a novel therapeutic strategy.Using human induced pluripotent stem cell-derived islets (SC-islets) and advanced CRISPR genome editing, I will generate precise knockout, inducible, and rescue models for hnRNPA2B1 and hnRNPM, two strong candidate regulators of beta cell splicing. I will combine functional assays, multi-omics profiling, and RNA immunoprecipitation followed by sequencing (RIP-seq) to define hnRNP-regulated splicing networks under basal and diabetogenic stress conditions. To increase the translational relevance, I will test SSOs targeting dysregulated splicing events in primary human islets from type 2 diabetes donors.By delivering the first mechanistic map of splicing regulation in human beta cells, BetaSpReg will expand our understanding of alternative splicing in diabetes, establish proof-of-concept for splicing modulation as therapy, and provide a foundation for RNA-based precision medicine in metabolic disease.


**Keywords:** Diabetes; beta cell dysfunction; alternative splicing; stem cell differentiation; splice-switching oligonucleotides
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'QLEX Creo – Bringing reach to the drone market.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The impact of drones and its commercial applications is often being compared with the disruptive force of the IT revolution. Soon, clients in all areas of the economy will begin to see the impact of drones on their operational processes – from the way they inspect construction sites to the way they receive goods like parcels or blood supply. The global market for commercial applications of drones – in 2016 estimated at about EUR 1.9 bn – will rise to as much as EUR 118 bn by 2020. But the application of today’s drones is limited by a crucial weakness in technology: reach. Depending on the construction type, today’s comparable industry class electric drones cannot fly longer 2 hours. Short flight time is one key barrier for a widespread usage of drones. Especially the transport industry is dependent on longer distance flights.At QLEX we developed the QLEX Creo – a winged drone that can takeoff and land vertically and achieve 4-5 hours of flight time. We achieved this breakthrough efficiency by completely rethinking the architecture, aerodynamics and propulsion systems of how drones can be built.QLEX has been running for two years, but was a secret until now. We spent the last 24 months in stealth mode designing, prototyping and testing the Creo and forming a highly skilled and experienced team of leading experts and engineers and startup shaped business developers.We now established our company, the QLEX GmbH, to assess the technological feasibility and commercial potential of the Creo. One key objective of this project is a record-breaking proof of concept by carrying out a delivery from German mainland to remote island Helgoland and return in one non-stop flight. No competing solution is close of being capable of achiving this.