RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Is heat shock protein mediated protection against ageing and protein oxidation tissue specific?' to be submitted under Sixth Framework.

assistant: **Abstract**

Aging is a biological process that is not yet understood. The free radical hypothesis of aging states that is a causal relationship between the oxidation status and lifespan such that the progressive deterioration of aging organisms is a consequence of cumulative oxidation damage. In line with this, intracellular accumulation of misfolded and oxidatively damaged proteins, e.g. carbonylated proteins, has repeatedly been associated with aging and the diseases of aging. Such accumulation can be counteracted by over-expression of molecular chaperones and proteases, e.g. the Heat shock proteins (HSPs), and also of oxidant defence proteins like Superoxide dismutase (SOD).Interestingly, elevated levels of specific HSPs as well as SOD can also prolong lifespan markedly. For example, the Tanguay lab has demonstrated that over-expression of HSP22 in mitochondria of motorneurons of the fruitfly Drosophila melanogaster increases the mean lifespan by over 30% and resistance to oxidative stress by 35%, and that the ef fect was cell type specific. In addition to carbonylation, the formation of advanced glycation end-products (AGEs) on proteins has been demonstrated to increase with age and age-related diseases and to destroy protein function and structure. AGEs are mostly formed via oxidative reactions such as carbohydrate and lipid oxidation and can therefore serve as a biomarker of those events.In this project I will use Drosophila to address the following questions:1) Do the levels and localization patterns of protein carbonylation and HSPs in cells and tissues differ between; a) young and old flies, b) short lived versus long lived flies.2) Is overproduction of HSP22 and other HSPs (e.g. HSP70) reducing protein carbonylation and if so, in what tissues?3) Is AGE-formation tissue an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A new therapeutic platform based on nanotechnology to promote T- and B-regulatory networks'.

assistant: **Innovation**

The complexity of autoimmune responses is a barrier to the design of strategies that can selectively purge the immune system of autoreactivity without impairing systemic immunity. Recently, Santamaria et al. have shown that nanoparticles (NPs) coated with type 1 diabetes (T1D)-relevant peptide–MHC (pMHC) complexes can restore normoglycemia in diabetic animals by blunting the diabetogenic autoimmune response without impairing systemic immunity. pMHC class II-NP therapy functions by expanding, in an epitope-specific manner, autoantigen-experienced T-regulatory-1 (TR1) CD4+ T-cells that inhibit the recruitment of other autoantigenic specificities by: (1) suppressing autoantigen-loaded antigen-presenting cells in the pancreatic lymph nodes (PLNs); and (2) promoting the differentiation of B-cells into B-regulatory cells. Importantly, they have shown that human T1D-relevant pMHC class II-NPs also promote human TR1 CD4+ T-cell formation in NSG mice engrafted with peripheral blood mononuclear cells from recent onset T1D patients. Here, I propose a multidisciplinary approach to test the following hypotheses: (1) Breg formation is driven by a cognate interaction between TR1 cells and autoreactive B-cells; (2) TR1-derived cytokines play critical roles in TR1-driven Breg conversion in vivo; and (3) the B-cells that are recruited to the PLNs of pMHC-NP-treated humanized NSG mice are enriched for Breg cells. Furthermore, I will work with the enterprise SEPMAG, to design a scalable magnetic separation device for future clinical development of these compounds.Collectively, NANOBreg will provide new insights into the biology of the TR1-Breg regulatory pathway and will enhance our knowledge on the mechanisms of action of this novel therapeutic approach. In addition, it will address a man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Windshield with improved bird-strike, erosion, de-fogging, de-icing and IR performance' (Wimper).

assistant: **Concept**

Objective of this project is the development upto the production of a prototype of a new pilot windshield and other windows with the focus on using state of the art technologies and coatings. This includes the complex interface between the airframe and the windshields. Especially, the capabilities versus improved bird-strike, anti-icing, anti-fogging and IR performance are taken into consideration.The consortium consists of 3 partners, all centred in the aeronautic industry with the expertise to develop and manufacture structural lightweight designs. Everyone is an expert on its main field. KRD Sicherheitstechnik GmbH (KRD) is a leading manufacturer of windshields and windows, so far mainly for ground transports (e.g. forestry harvesters, vessels, sport cars) but has contributed with prototypes for helicopter applications as well. Within their product portfolio you can find coated laminated car windshields with heating systems, usable for aeronautic applications for de-icing or de-fogging, too. The coating development for these applications as well as for scratch resistance is done at KRD premises.The Deutsches Zentrum für Luft- und Raumfahrt (DLR), Institute of Structures and Design has the excellence in the design of structural parts as well as the ability to perform simulations and tests to optimize the engineered parts concerning the structural behaviour, particularly under crash and impact loading. The institute will assist in the definition of testing methods and will perform testing sequences and bird-strike tests to evaluate the solutions. The DLR has developed a dummy bird, which will be evaluated during this project compared to real bird.The University of Stuttgart, Institut für Flugzeugbau (USTUTT) is the third partner and specialized in the production and de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Impact Loads on Concrete Structures'.

assistant: **Objectives**

This proposal is devoted to the investigation of impact loads on concrete structures. The design and dimensioning of concrete structures as redundant building structures, containments and other protection systems is a fundamental part of the present safety and reliability research. The clear knowledge of the various impact loads and of the interaction of those loads with reinforced or pre-stressed concrete structures is an essential basis for a realistic modelling and calculation and hence for the development of effective protection strategies against impact. The innovative nature of the project is the combination of both, modern numerical simulations as well as advanced testing methods using instrumented impact tests for validation of the numerical models. The overall aim of this proposal is to further develop the knowledge about the several types of impact problems and its special application on concrete structures. The result of the project should be a clear specification of these loads with recommendations for both, the suitable modelling and numerical simulation as well as the experimental reproduction. The secondary objective is to extend the experiences of impact testing and the connected specific measurement methods (high-speed cineradiography and photogrammetry, acoustic emission, etc). The project will lead to significant advances of understanding of short-time response phenomena of concrete structures and provide a basis for designs capable of withstanding such severe environments. The fellow has the strong intention to obtain his post-doctoral lecture qualification at the end of the fellowship period. This qualification will greatly assist in helping the applicant to attain professional maturity. Following his fellowship, the applicant intends to apply for f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated design and production of advanced sails' under Fourth Framework.

assistant: **Concept**

Sailing is an attractive and non-pollutant activity that provides many jobs. The manufacturing of advanced sails is a significant sector of the European Industry due to its high quality and to its success in the Olympic Games and other competitions. However, the market is becoming more demanding and the technology evolves rapidly; several countries (mostly USA and New Zealand) devote important efforts to this industrial sector and have developed innovative and competitive new products. The purpose of this project is to help the European advanced sail industry to meet this challenge. A technical description follows. Advanced sails are made of composite materials (e.g. a mylar matrix with an embedded network of kevlar reinforcement fibres). Two obstacles mainly constrain the technological development of the advanced sails manufacturing industry: - The coupled structural and aerodynamic behaviour of the sail-boat-sea assemblage is complex and there are no numerical models able to simulate it with reliability and accuracy. Because of this lack the design of sails and boats has to be semi-empirical. This strongly constrains the development of innovative solutions. - Even though the final shape of sails has to be curved, they are manufactured by seaming or sticking flat pieces. This has two main drawbacks: the sails are too heavy and, since the continuity of the fibres is interrupted at the seams, such connections constitute weak points. The technical objectives of this project aim to overcome both constraints: - An accurate and reliable numerical model (finite element code) to simulate the aerodynamic and structural behaviour of the sail-boat-sea assemblage will be developed. - An automated advanced sails production system will be built. Its main part will be a mould whose u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The worldwide first hybrid multi-functional municipal vehicle for a significant reduction of greenhouse gas emissions, fine particles and noise pollution in cities' in the context of a Horizon 2020 call.

assistant: **Objectives**

Holder is an innovative and highly awarded SME with a very long history in the development and production of special vehicles. In the more than 125 years long company history, several market-disrupting technologies have been developed.The main foundation for nowadays success was laid in 1954, when the company developed and introduced articulated steering. With this technology, Holder became world renowned in the segments for municipal vehicles, viticulture and horticulture. Today, Holder vehicles are sold in more than 50 countries worldwide and the company is market leader for multi-purpose vehicles with articulated steering. Building on the know-how and market position, Holder will now introduce the next breakthrough into the market: The Holder Hybrid Drive for lowest emission multi-purpose vehicles with articulated steering. This will allow the combination of an electric power source with a range extender for heavy work as well as a combination of different drive sources. With this innovative solution, Holder directly addresses a quickly emerging customer need: current municipal vehicles are solely powered by diesel engines, which are associated with NOx and PM emissions and thus, more and more affected by strict regulations. Cities and municipalities are therefore looking for clean andsustainable solutions to improve their air quality and fulfil all legal requirements without impeding their everyday work. This need will be fulfilled by Holder Hybrid Drive. Thus, Holder plans to subsequently equip all vehicles with the Hybrid Drive technology to generate a competitive edge and further extent the market leadership. For the initial market introduction, Holder addresses the European market for municipal services. The global distribution network will help to quickly enter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pulmonary Hypertension in COPD : from Observation to Emerging Novel therapeutic Insights and eXploration' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Chronic obstructive pulmonary disease (COPD) affects over 480 million people worldwide and accounts for more than 3 million deaths each year. Pulmonary hypertension is a common vascular complication observed in approximately 30% of COPD patients, characterized by vascular dysfunction and associated with higher hospitalization rates, impaired quality of life, and significantly reduced survival. To date, no clinical trial has demonstrated a clear benefit of pharmacological therapies for this severe complication, and only surgical interventions offer clinical improvement. Despite its substantial clinical impact, the mechanisms underlying the development of pulmonary hypertension in COPD remain poorly understood, thereby limiting effective clinical management and the advancement of novel therapeutic strategies.Through my project, I propose an integrative and innovative interdisciplinary approach that bridges clinical and experimental research. Using a database of COPD patients with and without pulmonary hypertension, together with a biobank of matched plasma and lung tissue samples, the project is structured around four main objectives to better understand the development of pulmonary hypertension in COPD:(i) define key clinical and functional risk factors (ii) identify circulating and tissue-based molecular signatures through multiomics analysis (iii) investigate vascular dysfunction using patient-derived cell models(iv) uncover potential new therapeutic targets capable of restoring normal vascular functionBy combining my host institution expertise in omics and large-scale data analysis with my experimental expertise in vascular biology and cellular models, this project will deliver mechanistic insight and translational outputs to improve patient management.


**Keywords:*
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European network for fetal transplantation' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

In utero stem cell transplantation is a novel therapy targeted at the fetus, within the uterus early in a pregnancy. This therapy is intended to treat a genetic disorder, diagnosed within the first 12 weeks of gestation, before the pathological effects become manifested. Currently, there are some successful cases reported and European centres are in a leading position in the field. However, there is a pressing need for consensus in many aspects of this therapy and a consortium of European centres with expertise in many areas of stem cells and transplantation will be uniquely placed to ensure that the in utero procedure can be used to maximum benefit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '3D Silicon Micromachining with Infrared ultrafast LasErs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of the present proposal is to initiate an interdisciplinary research program to develop 3D micromachining of silicon towards novel silicon photonics and microfluidic applications. We are motivated by the myriad of applications based on 3D micromachining of glass that peaked in the early 2000's, and still continues to impact integrated photonics and microfluidics, among other fields. These successes were achieved using lasers at wavelengths for which glass is transparent (most commonly 1 um, 800 nm and their second harmonics). Most of the important results demonstrated in glass can be carried over to silicon using a long-wavelength laser (beyond 1.1 um, silicon is highly transparent), though it is clear that the physics will be different, not least because glass is amorphous and silicon is crystalline. To this end, we propose an interdisciplinary research effort that includes first developing the necessary laser technology, then building up the physical understanding, and finally pursuing high impact applications. Our approach can be summarized as:(1) Developing a novel, femtosecond, high-energy laser at 1.5 um,(2) Developing in-situ diagnostics based on pump-probe imaging of the laser-material interaction,(3) Exploring the physics of the laser-silicon interaction,(4) Applying our physical understanding and laser technology as a platform to 3D micromachining of silicon towards novel silicon-photonics and microfluidic applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Development of a low cost, intelligent modular system for the diagnostic protection of electrical devices'.

assistant: **Concept**

This project aims to develop an intelligent modular family of protection devices to protect from overload of power of electrical devices and machinery. Such a system will provide major benefits over the cheap electrical protection devices, which offer only catastrophic protection and further benefits over bespoke protection systems that are generally inflexible and expensive. Industries require a device that monitors the situation, provides continuous feedback, provides a warning giving time to shut down and alarm the equipment preventing a safety critical situation and damaging situation being reached. Such a modular family of protection units with diagnostic capabilities will provide industry with a system with a high degree of flexibility, ease of use and compatibility at an economical cost. It is envisaged that the system will effectively and competently fill the gap between cheap, simple solutions and the expensive dedicated systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Interplay of microbiota and gut function in the developing pig – Innovative avenues towards sustainable animal production' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Low input farming occurs under non-SPF (specific pathogen free) conditions. The European ban on in-feed antibiotics exposes the piglets to a higher microbial environmental pressure. The postnatal priming of piglets with a diverse microbiota may affect the development of the piglet’s host-defense and gut functionality. By reversal, the piglets developing host-defense may affect the development of the gastro-intestinal microbiota. Moreover, this intricate interplay between gut microbiota and its host during the early phases of life is expected to also affect animal health and performance later in life. The gut microbiome is an immensely diverse ecosystem that has co-evolved with its host. Recent research on microbe-host interactions has provided novel insights into the role of commensal intestinal microbes in several physiological processes, i.e., from epithelial barrier development to immune development as well as neurological aspects. Nevertheless, we only start to understand the molecular mechanisms of the host microbe cross-talk. Recent conceptual as well as technological advances have set the stage for the integrated application of a complementary set of high throughput approaches for the comprehensive profiling of GIT microbiota composition and functionality as well as the animal’s intestinal function. In a multidisciplinary consortium, comprising 11 public and private partners from across and beyond Europe with complementary expertise in gut microbiomics, immunology and physiology, and animal genomics and nutrition, INTERPLAY will apply an integrated approach to arrive at a sound understanding of the interaction of early colonization of the intestine and the development of gut function. This knowledge will be exploited for the identification of innovative managemen