RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Edge and CLoud Computation: A Highly Distributed Software Architecture for Big Data AnalyticS' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Big data applications processing extreme amounts of complex data are nowadays being integrated with even more challenging requirements such as the need of continuously processing vast amount of information in real-time.Current data analytics systems are usually designed following two conflicting  priorities to provide (i) a quick and reactive response (referred to as data-in-motion analysis), possibly in real-time based on continuous data flows; or (ii) a thorough and more computationally intensive feedback (referred to as data-at-rest analysis), which typically implies aggregating more information into larger models. Given the apparently incompatible requirements, these approaches have been tackled separately although they provide complementary capabilities.CLASS aims to develop a novel software architecture to help big data developers to combine data-in-motion and data-at-rest analysis by efficiently distributing data and process mining along the compute continuum (from edge to cloud) in a complete and transparent way, while providing sound real-time guarantees. CLASS aims at adopting (1) innovative distributed architectures from the high-performance domain; (2) timing analysis methods and energy-efficient parallel architectures from the embedded domain; and (3) data analytics platforms and programming models from the big-data domain.The capabilities of the CLASS framework will be demonstrated on a real smart-city use case, featuring a heavy sensor infrastructure to collect real-time data across a wide urban area, and prototype cars equipped with heterogeneous sensors/actuators, V2I connectivity, and cluster support to present the innovative capabilities to drivers. Representative applications for traffic management and advanced driving assistance domains have been se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative rubber compounds for the shoe industry' (1998-2002).

assistant: **Concept**

Using polymeric materials in the shoe industry for outsoles has allowed the progress in fashion and technology, but it has caused some problems in sole-to-upper bonding. Surface preparation of substrates is key to guarantee joints with good adhesion forces, becoming a critical step in footwear manufacturing. Unsuitable treatments imply unstitching problems during the shoes' storage and use, meaning claims and returns. Solvent and chemical treatments, harmful for workers and the environment, are used at footwear factories, prolonging production times and adding costs to the final product. This proposal aims the development of innovative rubber compounds for outsoles, with similar properties than currently used rubbers and good adhesion properties so that the need of surface preparation prior to bonding is avoided or at least reduced. Thus, this research can bring the following goals:- Rubber formulations with improved compatibility with adhesives.- Simplified manufacturing process, avoiding surface treatments, which also implies costs reduction.- Elimination of hazardous chemicals, improving work safety conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Personalized Phenotype of Atrial Fibrillation for Accurate Treatment' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Atrial Fibrillation (AF) is the most common cardiac arrhythmia with an EU health cost of 13.5 billion annually. Despite the worsening that this cardiac arrhythmia provokes on the life quality of more than 6 million Europeans, AF therapies are suboptimal: success rate is below 60% including pharmacological and surgical approaches. AF is a multifactorial and progressive disease with high patient heterogeneity and therefore “the same treatment for all” is not optimal.GUIDE-AF addresses this challenge by a multi-sectorial and multidisciplinary research and training program in novel technologies for the individualization of the AF phenotype with the aim to increase treatments’ efficiency. GUIDE-AF will integrate data and knowledge from anatomical, biological, biomechanical and electrophysiological approaches to generate an accurate description of the patient-specific disease phenotype. The effect of the different AF treatments will be described and quantified for each AF phenotype in order to provide the best therapy choice.GUIDE-AF project will build a machine learning-based decision support system able to characterize the disease state and progression and able to predict the outcome of therapies. This algorithm will be based on technologies co-developed and validated by the candidate and the host and beneficiary research groups. GUIDE-AF will count with experts in cardiac arrhythmia management, AF characterization through image and signal analysis, basic and clinical research, as well as access to one of the largest AF patient database.GUIDE-AF will have an eminently multidisciplinary and clinical approach and will focus on providing a feasible and implantable solution for increasing the therapy success and reducing human and health system costs. This proposal includes int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High resolution mapping of genetic loci underlying variation in gene expression using a heterogeneous stock of mice' in the context of a Sixth Framework call.

assistant: **Objectives**

Many traits of biomedical interest can be modelled in the mouse and are known to arise from a complex interaction of quantitative trait loci (QTL) and environment. Yet, despite intense efforts, in the majority of cases the identity of the relevant genes remains obscure. Genetical genomics, the mapping of genetic factors contributing to variation in mRNA transcript abundance, is emerging as a powerful new tool for the molecular dissection of complex traits. Here I propose a project using the outbred, genetically heterogeneous stock (HS) of mice together with Prof. Flint in Oxford. By analyzing expression levels in 500 liver samples I will be able to map loci to intervals of approximately 250 kilobases, sufficient to identify the responsible genes. Importantly, by combining the information from gene expression, genetics and phenotypes it will be possible to determine the likely pathway from gene to phenotype. This work will give new insights into gene regulation and provide important implications for our understanding of the genetic basis of complex traits. I have an excellent training in molecular biology, genetics and immunology and need to improve my skills in statistical and bioinformatical analysis and to broaden my understanding of other complex traits. For this purpose the group of Prof. Flint would provide an excellent opportunity for me to achieve my goals. The proposed project combines my experience in microarray with the expertice of Prof. Flint on genetic analysis in outbred mice. The training will complement my skills in mouse genetics and I will be able to control the whole process, from breeding set-up to statistical analysis in both inbred and outbred mice. Altogether, this will promote my independence and reinforce my professional maturity, and the fellow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Talents Up for an International House' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Starting from the positive implementation of the previous COFUND project “TALENTS”, AREA, with the financial commitment of the Regional Government of Friuli Venezia Giulia (FVG), designed the new programme “Talents up for an International House” (TALENTS UP). Compared to the previous edition, TALENTS UP intends to strengthen the structuring effects obtained so far for the further development of the regional scientific system. It offers 7 high level incoming fellowships addressed to highly qualified researchers of any nationality, intentioned to implement a research training project in one of the 53 scientific institutions of the Coordination Network of FVG region or in one of the companies hosted in the 4 regional science and technology parks. This new programme focuses on the fellows’ complementary skills and on the improvement of the researchers’ working conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Science and technology week for future european scientists research on resources of energy energetic friends""' to be submitted under Fifth Framework.

assistant: **Abstract**

In the framework of this project an international research project competition on energy theme for future European scientists will be carried out. The best research project writers will be invited at Tallinn Technology and Science Centre ENERGY to present their projects with illustrative material (photos, videos, web-pages etc.) on an open Conference celebrating the European S&T Week 2001. The consortium also produces scientific merriment programs and the intensive media coverage of the event will introduce the science centre concept in all the Baltic States. The participating teams (consisting of 3 youngsters and a teacher) will enjoy working together and co-operating with experienced researchers on energy field. There will also be press conferences and mixed team quizzes for the participants. The whole event will be videotaped and disseminated as web page to partners and as agreed with EC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Distribution and Monetisation Ecosystem for Mobile Applications, Maximising Market Growth through Affiliation' (Gamesmondo) targeting Horizon 2020.

assistant: **Abstract**

Flexion Mobile’s Gamesmondo project targets the Android segment of the mobile games market, forecast to exceed €35billion per annum by 2017. The project, currently in TRL 6, is a major part of Flexion’s long-term strategy to build an openand fair market for Android games.The Android operating system is open. Hundreds of potential distribution channels exist and new entrants want to getinvolved in games distribution. In practice Android is currently dominated by one store. This is due to Google’s dominantposition and freemium games’ dependency on features provided by the distribution channel. Supporting multiple channelsmeans developers need to create and maintain multiple builds and relationships.In today’s market:• Developers are locked in to Google Play which is overcrowded, with limited discovery forcing them to spend heavily onadvertising• Remaining distribution channels suffer due to a lack of content• Developers’ payment monetisation is limited to what Google’s payments can support• Non-Google distribution channels are effectively locked out of the marketAn open market, where developers can distribute games in any channel (including Google Play) would drive overall industrygrowth and reduce issues for developers. Gamesmondo combines enabling technology, commercial relationships,monetisation and service management to create an aggregated network of games, distribution channels and users. Thisovercomes fragmentation and opens up the market without opportunity cost. Developers get routes to users otherwiseunreachable. Distribution channels get access to games and revenue otherwise unavailable and new players can enter themarket.Gamesmondo will define a new set of tools, rules and methods for both developers and end users, whilst building a versatilefoundation for ben
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Plasmodesmata, Symplasmic pores for plant cell-to-cell communication'.

assistant: **Innovation**

During evolution of multicellularity, cells differentiated to become specialized and interdependent. Multicellular organisms invented channels for nutrient exchange and communication between cells. Plants uniquely developed plasmodesmata, complex cell-cell connections traversing the cell wall. Roles ascribed to plasmodesmata include selective transport of signals, ions, metabolites, RNAs and proteins. Due to technical hurdles, composition, structure and regulation of plasmodesmatal conductance remain enigmatic. Genetic approaches to study plasmodesmata were hampered by lethality or redundancy. Novel technologies now set the stage for resolving roles of plasmodesmata in transport and signaling in an interdisciplinary approach. We will use proximity labeling proteomics to obtain plasmodesmatal composition, and PAINT and cryo electron tomography (cryoET) for near atomic structures. Models of plasmodesmata will be built from bottom up and top down approaches and combined with quantitative assessment of plasmodesmatal activity. Novel biosensor approaches together with knock down by genome editing will permit quantitation of transport of the diverse cargo. Single cell sequencing helps fine-tuning mutant selection and targeting of subtypes. Four labs will join forces: highly recognized experts in biophysics and cryoET (WB), advanced imaging and developmental signaling (RS), high-end proteomics and lipidomics (WS), and interactomics, transporters and cutting-edge biosensor technology (WF). We will iteratively address: (1) systematic quantitative identification of components, (2) their localization and dynamics, (3) structures and molecular building blocks of diverse plasmodesmatal types, and (4) transport and signaling mechanisms. We expect breakthrough discoveries and complete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quality Control of the Mitochondrial Gene Expression System in Health and Disease' (MITGEST) targeting Horizon Europe.

assistant: **Abstract**

Mitochondria produce most of the energy the body acquires through food, and are thus pivotal players in cellular metabolism. Central to mitochondrial biology is the DNA in the organelle (mtDNA): its maintenance, correct RNA processing, and efficient translation are all essential and must be coordinated to ensure proper mitochondrial function and cellular physiology. Defective maintenance or expression of mtDNA alters energy and nutrient metabolism, which are increasingly recognized to impact medical disciplines, ranging from hundreds of genetic disorders to neurodegeneration, immunology, transmissible disease, cancer and ageing. A deep understanding of the mitochondrial gene expression system and new methods are urgently needed to develop treatments for the full panoply of mitochondrial disorders that feature mtDNA perturbation.MITGEST will unite world-class academic excellence in mtDNA maintenance and expression with private sector expertise in nucleic acid chemistry and the development of mitochondrial therapeutics to address this urgent need. As the first research training programme in this field to take a fully integrated approach, our 10 doctoral candidates (DC) will elucidate how mtDNA is maintained and expressed and support the development of new methods to analyse RNA and DNA metabolism in mitochondria. These advances will complement and facilitate/enhance innovative treatment strategies and experimental medicine studies designed to mitigate mitochondrial dysfunction in a range of human diseases. Our network of 7 beneficiaries and 12 associated partners from 8 European countries and Israel builds on proven collaborations and establishes new partnerships to deliver intersectoral and multidisciplinary scientific and transferable skills training to our 11 PhD stude
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A quantitative and qualitative assessment of the socio-economic and environmental impacts of decoupling of direct payments on agricultural production, markets and land use in the EU.' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

An assessment of the proposed decoupling of direct payments, under consideration in the Mid-Term- Review of the CAP, has to be based on their potential benefits and the likely costs including marketable and non-marketable goods (such as environmental impacts) and services and the action of the economic decision-makers in the agricultural sector. This project has been designed to undertake socio-economic and environmental assessments of such measures, by using a set of existing and modified models for various levels of analyses. For economic analysis, farm-level mathematical programming and other models incorporating technical inputs (farm systems, agronomic and livestock characteristics and constraints) form the core of the proposed approach. The large technical inputs required by the economic models and the evaluation of impacts will be based on crop and livestock models linked to sets of databases (soil and climate particularly provided by the JRC), which are now accessible for the entire EU including the FADN farm accounts database. Different case studies will be implemented all around Europe. Sociologic and quantitative methodologies will be used to better understand the behaviour of the different farm family households in their specific environment and their adaptation strategy due to the CAP reform. The project team has internationally acknowledged expertise in such multidisciplinary research, thus enabling them to provide meaningful information to policymakers. While the proposal is oriented toward quantitative evaluation, the guidelines and information provided to policy makers will be enhanced by a more general socio-economic overview, which will point out advantages and limits of the results. During the project, social, employment and regional implications of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigating manual dexterity in healthy people and patients after stroke using multi-locus transcranial magnetic stimulation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Upper limb dexterity is a unique human ability commonly compromised by stroke. I suggest that the upper limb dexterity after stroke may be compromised as a result of dysfunctional inhibition of the nearby muscles. In patients with mild motor impairment, this results in a lack of independent finger movements. In moderately-to-severely affected patients, the pathological synergies pose a major problem, affecting both proximal and distal joint movements. I will develop methods for evaluating the neural origins of the upper limb dexterity and its recovery after stroke, and for improving compromised motor control by transcranial magnetic stimulation (TMS) combined with electroencephalography, electromyography, and structural magnetic resonance imaging. I will perform multi-muscle cortical mapping using a novel neuromodulation technology, namely multi-locus TMS (mTMS), which allows stimulation of the nearby cortical targets with millisecond-scale delays between the pulses without moving the stimulator. This unique feature of mTMS will enable us to determine local excitation/inhibition (E/I) interactions among the cortical representations of different upper limb muscles. I will evaluate whether abnormal control of independent finger movements can be structurally and functionally explained in terms of the local E/I balance at the motor cortex. Then, I will utilize this information to develop unprecedented mTMS protocols that take into account the individual organization of the motor cortex and the possibility of its selective neuromodulation. In summary, I aim to demonstrate that (1) the intricate patterns of local E/I balance at the motor cortex are involved in the orchestration of muscle synergies, (2) the malfunctioning of this complex circuitry after stroke can lead to abno