RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Exposing hidden targets of drug resistance in cancer by mapping the epitranscriptome at single-cell resolution'.

assistant: **Innovation**

Drug resistance is one of the biggest challenges in the clinical management of breast cancer (BC), but the underlying mechanisms are still not fully understood. What we do know is that epigenetic mechanisms play a key role in the adaptation of cancer cells to therapy, which is why they have become a prime field of investigation. Single-cell profiling of epigenetic DNA and histone modifications have already revealed intriguing and actionable insights into tumor heterogeneity. For the most recently discovered epigenetic layer however, which consists of RNA modifications, we have not yet reached single-cell resolution. The exciting potential of RNA modifications to fine-tune the processing and expression of mRNAs is currently an area of intense research termed ‘Epitranscriptomics’ and the most prevalent and best studied of these mRNA modifications, N6-methyladenosine (m6A), has recently been linked to drug resistance in cancer. Our lab has uncovered a new m6A-based layer of dysregulation of a major cancer pathway driving therapy resistance in BC. The ability to study m6A in single cells holds great promise as it would enable us to further delineate tumor heterogeneity and to find novel drug resistance targets that have eluded us so far. I propose to develop a method for streamlined m6A mapping at single-cell resolution (Aim 1), to apply it to triple-negative BC (TNBC) cells driven to chemoresistance in cell culture, mice, and human samples so as to determine uncharted targets of drug resistance (Aim 2), and to disrupt m6A-regulated chemoresistance targets in order to prevent therapy failure (Aim 3). These aims are aligned with my knowledge and skills related to both m6A and drug resistance. This unique and comprehensive analysis of the single-cell m6A methylome will provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Micro-Technologies and Heterogeneous Advanced Platforms for Implantable Medical Systems'.

assistant: **Concept**

The μTHALYS project aims to create a technology platform that enables a next revolution by bringing microsystem technology to the next level in terms of integration, miniaturization and multifunctionality and applying this development to address pending needs in health care.Several breakthrough materials, basic concepts and fabrication techniques will be developed based on silicon or going far beyond silicon: At the wafer scale integration level, integration of advanced polymers (optics, conductive polymers, ionic polymer-metal composites) will be studied. These will be applied in several novel subminiature actuator and sensor devices with broad application potential, amongst which microfluidic systems, pressure sensing arrays,In order to come to complex 3D systems combining modalities as optics, microfluidics, actuators and electronics, advanced device level fabrication and hybrid assembly technologies will be studied as well. Furthermore, the methods for packaging implants (flex/stretch interconnect technology, advanced interposers,…) will be pushed far beyond the current state of the art. The adoption of soft, and evenbioresorbable materials for packaging and interconnects will spectacularly improve the human-implant interface.Another important research line pursued is the study of ultra-low power electronics for medical implants: sensor interfacing, A/D conversion, signal processing, data communication and power transfer.These fundamental research activities will lead to many applied projects and valorization activities during and long afterwards the end of this grant. In the project itself, two main medical applications are targeted directly: a urinary pacemaker to prevent incontinence, and a new generation of implantable electrodes for neurology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'HEIRRI (Higher Education Institutions and Responsible Research and Innovation)' (HEIRRI), addressing dissemination and exploitation.

assistant: **Impact**

Higher Education Institutions and Responsible Research and Innovation (HEIRRI) foster an alignment of research and innovation (R&I) with the needs, values and societal expectations. The six key aspects of “Responsible Research and Innovation (RRI)”-societal/public engagement, gender equality, open access, science education, ethics and governance in R&I-are transdisciplinary included at all stages of formation of scientist and engineers, and other professional fields involved in R&I. HEIRRI will create and share on OA a stock-taking inventory constituted by a State of the Art Review and a Data Base. The inventory will gather results of other EU funded RRI projects, good cases and practices of RRI and RRI Learning. Also, different stakeholders involved and/or affected by R&I will participate in a debate and reflection process on RRI Learning through online and offline Forum actions.  Results from the inventory will represent the basis for RRI Training programs and formative materials, offering the students knowledge and skills to develop viable solutions to specific problems related to R&I, integrating theory and practice. They will be designed for the different HEI educational levels (undergraduate, MD and PhD, summer courses and MOOC), mainly based on Problem based learning methodology, and supported by multimedia materials (videos and microvideos, 2.0 materials, etc.). All results and products elaborated by HEIRRI will be uploaded on OA at RRITools Platform.An internationalization plan will guarantee their spreading awareness and future use by HEI from Europe and beyond. A global scope and expertise on RRI will be provided by HEIRRI consortium that consists of 5 European HEI (Universitat Pompeu Fabra (UPF), Universitetet I Bergen (UiB), Aarhus Universitet (AU), Institu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'aDverse wEather eNvironmental Sensing systEm' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Current driver assistance systems are not all-weather capable. They offer comfort and safety in sound environmental conditions. However, in adverse weather conditions where the accident risks are highest they malfunction or even fail. Now that we are progressing towards automated cars and work machines, the requirements of fully reliable environment perception are only accentuated. The project is focusing on automated driving and its key enabling technology, environment perception. Consequently, project’s main objective is to develop and validate an all-weather sensor suit for traffic services, driver assistance and automated driving. Extended driving environment perception capability with smart, reliable and cost-efficient sensing system is necessary to meet the targets of all future driver assistance system applications. These targets need to be met regardless of location, weather or time of the day. Only by means of reliable and robust sensing system upcoming automated driving will be possible. The new sensor suit is based on a smart integration of three different technologies: (i) Radio radar, 77 GHz-81 GHz, (MIMO Radar); (ii)  Gated short wave infrared camera with pulsed laser illumination (SWIR camera)and (iii) Short-wave infrared LIDAR (SWIR Lidar). Such a full fusion approach has never been investigated before, so that the outcome will advance the state-of-the-art significantly and demonstrate the potential of all-weather environment perception.DENSE innovation lies in the provision of a brilliant restored enriched colour image from a degraded infrared image and consequently, this is followed by a variety of application fields for low cost solutions. An important aim is also to close the gap to US developments in the field and avoid their restrictions for sellin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The mammalian body plan blueprint, an in vitro approach' in the context of a Horizon 2020 call.

assistant: **Objectives**

The development of an embryo requires the spatially structured emergence of tissues and organs. This process relies on the early establishment of a coordinate system in the form of three orthogonal axes that act as a reference for laying down the body plan, a template for the organism. Genetic analysis of this process has revealed an underlying transcriptional blueprint that links the coordinate system and the body plan. However, the way in which the gene products contribute to the emergence of the body plan remains an open question. A reason for this is that this process involves feedbacks and integration between the activity of Gene Regulatory Networks (GRNs) and the mechanics of multicellular ensembles, and that probing this relationship is experimentally challenging. In the case of mammalian embryos, which are particularly important as models for human development, our gaps in knowledge of these events are larger than in other organisms. This is partly due to the challenges associated with uterine development but also, and increasingly, because of the cost of mice and the difficulty of obtaining large numbers of embryos, as required for mechanistic experiments. In this project we shall use gastruloids, a novel and versatile Pluripotent Stem Cells based experimental system that we have developed for the study of mammalian development, to gain insights into the molecular and cellular basis underlying the emergence of the mammalian body plan. Gastruloids lack anterior neural structures and over a period of five days become organized in the fashion of a midgestation mouse embryo. We shall use the experimental versatility of the Gastruloid system to probe into the functional relationships between the mechanical activities of multicellular ensembles and the dynamics of GR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainable tecHnologies enablIng Future Telecommunication applications' to be submitted under Horizon Europe.

assistant: **Abstract**

The global market for next-generation telecommunications systems (B5G, 6G) demands products with higher speeds, better energy efficiency and sufficient power output. The project aims to meet these needs by developing and industrializing next-generation semiconductor technologies (SiGe BiCMOS for ST, RF GaN for UMS) and the associated integrated circuit design and characterization environments. Innovative analog and digital RF integrated circuits will be designed with the technologies developed and integrated as ‘FEM’ modules of innovative telecommunications system demonstrators.New assembly techniques that can solve RF signal integrity and heat dissipation issues, or greatly simplify RF systems, will also be explored.Demonstrators of innovative telecommunications systems will be developed (10 demonstrators; by NOKIA, SAFRAN, SIAE, and other partners), to validate new semiconductor and assembly technologies, on use cases envisaged for wireless B5G/6G networks (more particularly for network access and network trunks), very high-speed optical networks, and Earth observation and satellite telecommunications.The SHIFT consortium brings together players covering the entire value chain of these telecommunications applications, from laboratories to manufacturers, thus guaranteeing the highest scientific level and the possibility of validating the work carried out on suitable demonstrators. Activities will include environmental and economic impact assessments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Dual circuit flow battery for hydrogen and value added chemical production'.

assistant: **Concept**

DualFlow develops a radically new energy conversion and storage concept that combines water electrolysis, battery storage and co-production of decarbonized chemicals into one single hybrid technology using water soluble redox mediators as energy transfer vectors. The system can be operated for electricity storage or for energy conversion to hydrogen and value added chemicals. During energy storage operation, the system works as a conventional stationary flow battery. The energy conversion starts when the battery is full but there is abundant inexpensive green electricity available. Now the battery is chemically discharged in a mediated electrolysis to produce hydrogen and value added chemicals. The energy conversion is realized by pumping charged battery electrolytes through reactors. For hydrogen production, reactor is filled with catalytic particles to catalyze electron transfer and hydrogen evolution. For value added chemical production the reactor consists of biphasic system where charged electrolyte oxidizes chemicals in an organic phase. The reaction products are then extracted into the organic phase. The energy conversion operation requires only reactors and catalyst for hydrogen evolution, indicating that the additive costs of the dual circuit is minimal. The concept results in flexible system capable of both energy storage and energy conversion to hydrogen. We strongly believe that this concept offers possibilities to produce inexpensive hydrogen, in a flexible manner without utilizing any critical raw materials.


**Keywords:** flow battery, mediated electrolysis, electrosynthesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Micro Synthetic Jet Actuator Manufacturing' to be submitted under Seventh Framework.

assistant: **Abstract**

The objective of the project is to develop and manufacture µSJA based on silicon technologies. To reach the required output velocities of the µSJA, the chamber and the exit channel or nozzle will be optimized using different analytic and numeric methods. Based on the results of the optimization, a design will be investigated and transferred to silicon based structures. The production of the µSJA will be performed in the clean rooms of the ZfM and will be realized on wafer-level. The two different parts of the µSJA, the cavity and the diaphragm are micro-machined and wafer bonded in order to form the actuator. The diaphragm-wafer’s backside is wet etched in order to produce a membrane in two different thicknesses, 40 µm and 70 µm. The cavity-wafer in contrast, is prepared by a sequential etching process with the same etchant. In the first step the orifice will be preliminary etched with a depth of 400 µm. The second step equates the continuing etching of the orifice and the production of the cavity geometry. The achievements of these two processes are 3D nozzle structures of the orifice in a required aspect ratio and a very small cavity, resulting in a higher pressure gradient which leads to a much higher jet velocity compared to a dry anisotropic etched orifice combined with a huge cavity. This creates the main advantage compared to known layouts. Then, the two parts are bonded to form a small cavity with an orifice on the one side and a diaphragm on the opposite side. Finally, the piezo disc will be mounted on the back side of the diaphragm into the wet etched cavity. To integrate the electro mechanical transducer, in this case the PZT element, into the system, investigations of reactive bonding technologies for the use of PZT silicon bonding will be done. Thus, the st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Disease and immunity in marine brown algae' (DIMBA).

assistant: **Innovation**

The first-ever genome project on a seaweed (Ectocarpus siliculosus) presents an unprecedented opportunity to study an algal host-pathogen interaction with state-of-the art molecular approaches. This model has the strength of being both of environmental and fundamental relevance, enabling issues to be addressed ranging from the impact of diseases in marine ecosystems to the evolution of pathogenicity among protists. As a Marie Curie IEF Fellow, I have been setting up a laboratory-controlled pathosystem involving the oomycete pathogen Eurychasma dicksonii and developed robust protocols on this model. My results demonstrate, for the first time in brown algae, the existence of a genetically-determined immunity, most probably mediated by programmed cell death and conserved across the whole phylum. The aim of this proposal is to build on my current work and support the following long term research objectives: 1) Investigating complementary aspects of the defence mechanisms of brown algae: a) programmed cell death as a component of Ectocarpus innate immunity; b) metabolite profiling of algae suceptible or resistant to infection, with the potential of identifying new bioactive (antifungal) compounds 2) Deciphering some infection mechanisms of Eurychasma, through a cDNA-based gene discovery approach. As Eurychasma is the most basal oomycete known so far, this undertaking will give unprecedented insights into the evolution of infection strategies within this lineage, and more generally among protists. 3) Looking for molecular signatures of host-pathogen coevolution in the field, as a contribution to the understanding epidemic impact on algal populations and coastal ecosystems. During the course of this work, a proactive approach will be used towards the identification of bioactiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Genetic profile of breast cancers in mediterranean countries: implications in preventive and predictive medicine' (1998-2002).

assistant: **Innovation**

The BreastMed consortium will compare genetics of breast tumours at the clinical and molecular levels between 2 european and 3 mediterranean countries,considering different risk factors and clinical presentation heterogeneities. Germline BRCA1 and BRCA2 mutations will be sought, and molecular profiles of gene expression of a limited number of selected genes will be analysed in breast tumours by low-density cDNA chips. In 3 years, 750 tumours or patients (and their family if hereditary predisposition is suspected), will be recruited for the study. Better genetic counselling to breast cancer risk families, medical cares adaptated to the diagnosis of hereditary breast cancer risk or expression profiles of sporadic breast tumours, and standards for DNA chips manufacturing and comparisons are the main expected results of the consortium.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ultra-thin packaging solutions using thin silicon' (FLEX-SI), addressing dissemination and exploitation.

assistant: **Impact**

The project aims at the development of different ultra-thin electronic packaging solutions based on thin flexible Si chips with a thickness < 50 µm. Therefore it is necessary to develop wafer thinning, handling and shipping techniques. The material properties of ultra-thin silicon including the electrical performance under bending stress, the long term behaviour and reliability will be investigated. Derived from different industrial applications 3 ultra-thin packaging technologies are planned: multi chipmodule with active component integration into flexible substrates (MCM-L), chip-on-chip and chip-in-paper. The electrical interconnections will be performed mainly by flip-chip technology.Demonstrators from different applications using these ultra-thin packaging technologies will be assembled and qualified:- mobile telecommunication device employing MCM-L,- hearing aid using chip-on-chip,- identification system (smart label) with chip-in-paper.<50 µm.Therefore it is necessary to develop wafer thinning, handling and shipping techniques. The material properties of ultra-thin silicon including the electrical performance under bending stress, the long term behaviour and reliability will be investigated. Derived from different industrial applications 3 ultra-thin packaging technologies are planned: multi chipmodule with active component integration into flexible substrates (MCM-L), chip-on-chip and chip-in-paper. The electrical interconnections will be performed mainly by flip-chip technology.Demonstrators from different applications using these ultra-thin packaging technologies will be assembled and qualified:- mobile telecommunication device employing MCM-L,- hearing aid using chip-on-chip,- identification system (smart label) with chip-in-paper.Objectives:The main objectiv