RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Open Researchers 2020' to be submitted under Horizon 2020.

assistant: **Abstract**

Open Researchers 2020 is the 9th Andalusian experience in the European Researchers’ Night designed to increase the awareness and perception of research as a solution to the huge challenges facing society. ‘A science open to citizenship: Facing the challenge of creating a sustainable future for all’ is the main idea of the project, which has been conceived in a time where becomes clearer that we must join efforts to find sustainable, equal, innovative and creative solutions to achieve Sustainable Development Goals and the societal challenges that we are facing in Europe. Understanding that science is present in our daily lives through many disciplines involved, it should be accompanied by a scientific culture that will prepare future citizens to a reality full of challenges. It is essential to promote youth interest in Science by opening it to the general public through researchers in an accessible way in order to implement public engagement in RRI. Fundación Descubre will coordinate this project, based on its experience through the last decade working with relevant projects and fundamentally in its consortium experience in the previous NIGHT projects. The consortium is composed of nine Andalusian universities, the Spanish National Research Council (CSIC), Andalusian Foundation Progress and Health, and the Royal Botanical Garden of Córdoba. The project's major strength is the numerous educational and entertainment activities taking place on main streets and squares, theatres, and historical buildings of the eight Andalusian cities, with a high mobilization of researchers. The European dimension will be underlined by the active involvement of researchers with European funds and Marie Skłodowska-Curie fellows, in the EU Corners and in the pre-events organized before the Ni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Climate impacts of a HYdrogen Economy – the pathWAY to knowledge' to be submitted under Horizon Europe.

assistant: **Abstract**

The HYway project will be the most comprehensive study on environmental effects of large-scale hydrogen usage to date. HYway is led by a team of experienced scientists who have already conducted extensive research on the climate effects of hydrogen. To fully understand the climate effect of hydrogen emissions, HYway will constrain the hydrogen budget by novel work on surface emissions, measurements of leaks and soil uptake fluxes, and application of a global atmospheric model ensemble combined with observations to quantify the atmospheric sources and sinks of hydrogen. To improve monitoring tools for hydrogen leakages, HYway will develop novel emission modelling and installation-level emission measurements. We will measure the hydrogen soil sink using flux chambers and instrumented drones, and we will use this knowledge to improve process-based models of the sink. The Global Warming Potential of hydrogen and its Effective Radiative Forcing will be quantified, including the component contributions from methane, ozone, stratospheric water vapour and aerosols. HYway will also quantify several environmental effects associated with hydrogen emissions such as stratospheric ozone depletion and air pollution. HYway will build on existing methods to create realistic future scenarios to fully explore the climate and environmental impacts of a hydrogen economy, including co-emissions and associated reductions in fossil fuel-related emissions. HYway includes a large advisory board of industry partners, several of them from established hydrogen collaborations. The advisory board will assist in estimating hydrogen leakage rates and in establishing realistic scenarios for a future hydrogen economy. By evaluating the potential climate and environmental impacts of a hydrogen economy, HY
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Catalytic Metal Organic Frameworks-Functionalized Photoelectrodes for Efficient Solar-Driven Plastics and CO2 Valorization' (SOLAR-CATMOF).

assistant: **Concept**

Increasing plastic waste poses significant environmental and health risks through pollution, toxic chemical release, and CO2 emissions. Polyethylene terephthalate (PET), used in bottles, is especially challenging to recycle effectively and often ends up in landfills. This proposal aims to develop an innovative solar-driven technology that efficiently combines two waste streams (PET and CO2) to produce useful fuels and chemicals, contributing to a more circular and eco-friendly future. Based on the applicant’s expertise in the synthesis and characterization of MOFs, we aim to harness this knowledge to further develop MOF-based photoelectrodes. Additionally, by leveraging the host institution’s research on silicon-based photoanodes and photocathodes for solar photoelectrochemical (PEC) processes, we have identified three key objectives. The first is to create a new and simple method for engineering defects into MOF-based silicon for efficient PEC applications by incorporating monocarboxylic acids during synthesis. The second objective is to study the role that defects and imperfections play in controlling the efficiency and selectivity of PEC reactions. The third objective is to apply the developed catalysts for the first time in the solar driven PEC oxidation of pretreated real-world PET into glycolic acid (used as a feedstock in the cosmetics and pharmaceutical industries) while coupling it with PEC CO2 reduction reaction to concurrently produce value-added products at both electrodes, demonstrating the advantages of PEC devices for scalable commercial applications. The success of this proposal relies on the applicant’s expertise in MOF synthesis and defect engineering, along with the host institution’s proficiency in electrode modification and development of functional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Therapy for regeneration of Heart Muscle based on targeted delivery of exosomes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Given the poor regenerative potential of the adult heart after heart failure (HF), therapies capable of contributing for cardioprotection and cardio-regeneration are of great need. Recent advances in pharmacologic therapy and stem cells are currently not enough to address HF. The hypothesis of this project is that exosomes, nanovesicles secreted by cells may be a potential therapy for HF. Exosomes may offer advantages relatively to cell-based therapies regarding efficacy (does not require engraftment and survival), processing and cost. The main objective of the current project is to develop an effective strategy to deliver exosomes by intravenous (IV) injection into the heart (targeting) and to maximize exosome regenerative potential (bioactivity). Therefore, the project aims to develop a non-cellular-based therapy to regenerate the heart after infarction based on the targeted delivery of exosomes. Undertaking this research along with formal training and mentoring will enhance my academic profile, scientific experience, and content expertise in nanobiotechnology, to enable me to develop into an independent, leading researcher. The proposed research contributes to the EU priority of addressing the societal challenge of improving lifelong health and wellbeing of all.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Using Reconstituted Stress Granules to Gain Insight into the Molecular Pathology of Neurodegenerative Diseases' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

When cells experience stress, most protein synthesis pauses and so-called stress granules (SGs) form which store and protect mRNAs. SGs are crucial for stress adaptation and prevention of cell death. However, SGs are also implicated in age-related neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In these diseases, SGs persist longer than normal and turn into harmful aggregates which cells cannot dissolve.Despite the importance for human health, we only know very little about how normal SGs convert into disease-causing aggregates. Ground breaking work from the Hyman and Alberti labs could recently demonstrate that SGs behave like liquid droplets which solidify over time. Importantly, this transition is promoted by disease-associated mutations in SG components.SGs form through protein-protein interactions which critically depends on the Ras GTPase-activating protein-binding protein 1 (G3BP1). The Hyman and Alberti labs could recently generate G3BP1 droplets in vitro and could show that droplet formation is promoted by mRNAs. For the first time, we have a minimal SG system that can be used as a tool to mechanistically dissect SG formation and disease association. I propose harnessing this system to generate complex droplets that resemble physiological SGs. Ultimately, my objective is to elucidate how proteins with disease-causing mutations influence SG properties and dynamics, thus allowing me to identify the molecular changes that underlie neurodegenerative diseases.The proposed work is to take place in the teams of A Hyman and S Alberti, world leaders in the field of liquid droplets. Both groups are uniquely situated in the same institute which offers cutting-edge facilities and extensive training opportunities. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards Higher Levels of Autonomy and Robustness in Space Operations through Uncertainty Management and Quantification' (THOR).

assistant: **Concept**

The overarching goal of the THOR research project is to augment space operations autonomy and robustness through uncertainty management and quantification. This involves a bottom up process where novel uncertainty estimation and propagation techniques will be employed to be subsequently embedded within a stochastic robust controller. The main outcome will be a robust non-linear non-gaussian integrated guidance, navigation and control strategy with both model-based and exogenous disturbance estimation. Since both uncertainty sources are quantified, a more reliable and efficient space operation management and planning will be obtained.  The THOR scenario relates to asteroid exploration which is one of the most challenging and uncertain space operations nowadays. This is due to the limited asteroid data known prior to the arrival if the body is visited for the first time. Two mission phases can be clearly distinguished: on-orbit data collection where most of the uncertainty will be removed by estimation; then, an entry descent and landing critical phase where the stochastic robust controller will use the previous uncertainty knowledge, is envisioned.  The THOR project methodology and results are expected to advance current state-of-the-art in autonomous spacecraft guidance, navigation and control, thus enabling more advanced space exploration mission concepts with a higher scientific return, without loss of generality.


**Keywords:** Astrodynamics. Spacecraft guidance, navigation and control. Robust control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modelling human neuroinflammatory and demyelinating disease in transgenic and mutant animals' in the context of a Fourth Framework call.

assistant: **Objectives**

In human demyelinating diseases like multiple sclerosis (MS), inflammatory reactions are the primary cause of myelin damage. While experimentally-induced animal models for MS have provided much insight into the involvement of myelin- specific T-cells in the early phases of disease, the peripheral immune response alone is unable to account for the widespread and selective destruction of myelin that occurs in MS and that leads to impairment of neurological function. A critical additional pathogenic factor, for which characterised animal models have not yet been developed, relates to disturbances of the cellular and molecular environment within the central nervous system (CNS) itself, for example by the deregulated production of pro-inflammatory molecules by activated glia. Tumour necrosis factor a(TNF)is a major effector molecule of the immune- system, and is now believed to play a critical role in the pathogenesis of MS and several other neuroinflammatory and neurodegenerative CNS diseases such as AIDS dementia and Alzheimer's disease. We have recently demonstrated that TNF overexpression in the CNS of transgenic mice, can indeed trigger a spontaneous inflammatory demyelinating disease with many of the clinical and histopathological hallmarks of MS. To further develop this phenotype as a model for human CNS inflammation and demyelination, major questions concerning the molecular and cellular mechanisms by which TNF triggers disease need to be addressed. The core of the present proposal centres around the development and application of state-of-the-art techniques in transgenic and conditional gene targeting methodology, to introduce specific disturbances into the micro- environment of the CNS, as an approach to generate animal models of human CNS disease with precise gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cocoro Advanced Lingerie, the ultimate reusable absorbent underwear' (COCORO) under Horizon 2020.

assistant: **Objectives**

Disposable menstrual products represent around 1M of the 3B tons of waste produced in the EU every year. Mostly composed by highly pollutant plastics, they have a huge impact on the environment. The pollution and greenhouse gas emissions they cause contribute to climate change, as well as material loss – a significant problem in the EU, which is highly dependent on imported raw materials. Moving towards a circular economy is an urgent need for the feminine hygiene industry to contribute to the competitiveness of the EU economy. Only two new companies in the US and Australia have recently started selling absorbent underwear as an alternative to pads. Yet, they cannot fully compete with pads given their insufficient absorption capacity and practicality. These products are also very expensive to get in Asian and European markets, which are the largest pads markets. Femmefleur has developed the ultimate alternative to disposable external menstrual hygiene management (MHM) products: a highly absorbent, breathable, practical and comfortable reusable underwear. Cocoro Advanced Lingerie uses a combination of cotton and polyester  treated with an innovative technology that absorbs corporal fluids like menstruation or slight urine loss, satisfying women’s needs in MHM and beyond.Its unique features are highly competitive as our disruptive technology and design guarantee a cost-effective and ecological solution for MHM. Increasing their absorption capacity, these panties can be commercialized in other market segments such as urine incontinence or maternity. This translates into a high-potential users group, as only in the EU it represents around 190M people. The successful results gathered together with the huge business opportunity ahead allow us to establish two main goals for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nanobiosensors for Health Monitoring' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The drive to understand biology and medicine at the molecular level with accurate quantitation demands much of current high-throughput analysis systems. Nanomaterials and nanotechnology combined with modern instrumentation have the potential to address this emerging challenge. Using a variety of nanomaterials for multiplex diagnostics and imaging applications will offer sensitive, rapid and cost-effective solutions for the modern clinical laboratory. New nanomaterials, i.e., metallic nanoparticles labelled with plasmonically enhanced fluorescent metal complexes, will be developed to achieve optical-encoding capabilities for selective tagging of a wide range of medically important targets, including bacteria, cancer cells and individual molecules, such as proteins and DNA, in a single assay. We envision further development in this field will provide numerous advanced tools with increased sensitivity and improved multiplexing capability, for unique applications in molecular biology, genomics and drug discovery. To achieve these ambitious goals will require the synthesis of a variety of luminescent and redox active metal complexes, nanoparticles and polyelectrolytes for encapsulation. It should be noted that the basic science proposed in this application will lead to a “platform” technology finding diverse applications in areas such as new forms of renewable energies (hydrogen storage for fuel cells), display devices and sensors for individual analytes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Decadal to multi-deCadal Global Predictions of Compound Events' in the context of a Horizon Europe call.

assistant: **Objectives**

Compound events (CEs) can pose significant threats to societies, economies and ecosystems around the world, especially when amplified by anthropogenic climate change (ACC). There is therefore a strong need for skillful, reliable and actionable predictions of how CEs are expected to change in the next decades, to support governments and stakeholders in implementing robust adaptation strategies. In this project, we will develop a method to improve near-term projections of CEs at the global scale, taking into account their response to both climate variability and long-term warming, and develop a sound physical mechanism understanding of their meteorological drivers. First, we will constrain climate projections with decadal climate predictions, from the Coupled Model Intercomparison Project Phase 6, with a novel method to reduce the uncertainty and increase accuracy of ACC predictions up to 30 years. Then, we will apply an innovative method grounded in dynamical systems theory for quantifying CEs and link them to physical extremes in the global regions where the prediction of events shows high skill. We will specifically focus on temperature-(low) precipitation as related to summer heatwaves and precipitation-wind as a proxy for storms. The analysis will elucidate what drives CEs in the context of global warming and climate variability, to what extent they can be predicted on decadal to multi-decadal time scales, and how their frequency, intensity and persistence is expected to change in the future. We will furthermore explore the atmospheric drivers of the CEs, to elucidate specific physical mechanisms at the origin of the events. The outcomes of the project will be significant for the scientific community, since they will improve the understanding of how CEs respond to AC