RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Rigorous Search Space Reduction' (ReduceSearch).

assistant: **Innovation**

In our world of big data and theoretically intractable problems, automated preprocessing to simplify problem formulations before solving them algorithmically is growing ever more important. Suitable preprocessing has the potential to reduce computation times from days to seconds. In the last 15 years, a framework for rigorously studying the power and limitations of efficient preprocessing has been developed. The resulting theory of kernelization is full of deep theorems, but it has overshot its goal: it does not explain the empirical success of preprocessing algorithms, and most questions it poses do not lead to the identification of preprocessing techniques that are useful in practice. This crucial flaw stems from the fact that the theoretical kernelization framework does not address the main experimentally observed cause of algorithmic speed-ups: a reduction in the search space of the subsequently applied problem-solving algorithm. REDUCESEARCH will re-shape the theory of effective preprocessing with a focus on search-space reduction. The goal is to develop a toolkit of algorithmic preprocessing techniques that reduce the search space, along with rigorous mathematical guarantees on the amount of search-space reduction that is achieved in terms of quantifiable properties of the input. The three main algorithmic strategies are: (1) reducing the size of the solution that the solver has to find, by already identifying parts of the solution during the preprocessing phase; (2) splitting the search space into parts with limited interaction, which can be solved independently; and (3) identifying redundant constraints and variables in a problem formulation, which can be eliminated without changing the answer. This will raise the scientific study of preprocessing to the next le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sustainability Impact Assessment of Strategies Integrating Transport, Technology and Energy Scenarios' (TRIAS) targeting Sixth Framework.

assistant: **Abstract**

The future framework of the transport system is intimately linked with the energy supply. This is what happened in the past, when the relatively cheap availability of petroleum oil shaped the expansion of the transport system facilitating with high levels of mobility. These patterns have generated an unsustainable road traffic growth, which in turn imposes increasing concerns for its burden in terms of pollution, accidents, noise, etc. and for the future availability of the quantities of fuel required. Given that most of the dispersion trends will likely continue in the future, an assessment of potential trajectories for technologies changes in the transport and energy fields is of crucial importance to develop sustainable transport strategies.Thus, transport and energy constitute two major supporting systems of human life such that strategies changing technologies in these fields will provide significant impacts on the economy and potentially also on the societal development. Therefore integrated assessment of transport technologies and transport energy supply together with economic, environmental and social impacts is required. For this purpose TRIAS suggests to use a set of established models covering these aspects and to apply them in an interlinked manner to analyse the full picture of impacts induced by strategies including technology, transport and energy scenarios. Investigated scenarios will either be developed in TRIAS and will be taken from external sources like other European projects, national or international studies. Such scenarios will be discussed in the course of ad-hoc forums involving all relevant stakeholders. The applied models will act at European scale (EU25) and will include: POLES for energy modelling, ASTRA for transport modelling and integrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '13th European Conference on Chemical Vapour Deposition' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

EUROCVD13 will be a forum where senior scientists and young researchers mainly from Europe, but also from other countries will interact and exchange cutting edge approaches, methods, models, and results on the processing, characterisation and evaluation of micro- or nano- structured materials in the form of films, tubes and particles. The Conference is built around the Chemical Vapour Deposition (CVD) technique. Although chemistry is a key word in CVD, this is by essence a multidisciplinary method: Physics, Chemistry, Mechanics, Surface Science, Materials Science, and Chemical Engineering are necessary in order to understand and optimise processes and materials. It is thus mandatory to efficiently cover all these fields.This will be ensured (i) by appropriately selected, sessions (Fundamentals, Modelling, Materials Type, Nanoscale Films and Particles, Metalorganic CVD, Coatings, Assisted CVD Techniques, Technological Advances, Characterisation). (ii) by the absence of parallel sessions, (iii) by the introduction of each session by the invited lectures of two internationally recognised experts, (iv) by providing extended periods of interactions among participants through poster sessions and informal activities such as offered coffee breaks, lunches and dinners or excursions and other social events, (v) by ensuring a high level infrastructure for the Conference.CVD is a strongly industry implemented technique. For this reason, equipment and precursor manufacturers, and industries and R&D centres involved in the Microelectronics, Hard and Protective Coatings, as well as end users such as integrated circuits manufacturers or energy producers have already been invited. A special session will be devoted to the identification of industrial needs and material problems that can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Overcoming the Barriers of Brain Cancer Treatment: Targeted and Fully NIR Absorbing Photodynamic Therapy Agents with Extremely Low Molecular Weights and Controlled Lipophilicity' under Horizon 2020.

assistant: **Concept**

Cancer is the second leading cause of death worldwide, accounting for a total of 8.8 million deaths in 2015. Research efforts have resulted in significant increase in 5-year survival rates for some cancer types, however this is not the case in brain cancer. Three fundamental issues are at the core of this reality: 1) High percentage of inoperable brain tumours; 2) Limited number of drugs that can pass through the blood-brain barrier and 3) Absence of effective targeted brain cancer therapies. Photodynamic therapy (PDT) has the potential to be a selective, effective and non-invasive alternative to current treatments, however to date it is only applicable to a small group of cancers. Realization of non-toxic, water-soluble and photostable PDT agents, with strong near infrared absorption for deep tissue penetration, that also realizes high singlet oxygen generation efficiency and effective targeting, is the key for widespread use of PDT for majority of cancers. For brain cancer specifically, low molecular weights (Mws) and controlled lipophilicity is needed as well. The ultimate aim of INFRADYNAMICS is to create and validate the first series of advanced PDT agents that meet all these requirements and to demonstrate that a significant impact on brain cancer survival rates could be achieved. First, a series of advanced fluorophores that combine the two contradicting entities – absorption in NIR region (>700 nm) and low Mws – will be realized using novel design approaches which also allow a synthetically-viable pathway to tune lipophilicity. Then, appropriate heavy atom modifications for sensitization will be pursued. Most importantly, these sensitizers will be decorated with known and novel handles towards specific targeting of glioblastoma cells to attain the final PDT agen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Historic response of a wide-ranging carnivore to climate change' (SURVIVOR) under Horizon 2020.

assistant: **Objectives**

This proposed project investigates novel ways of predicting the effects of future climate change on the survival of animal species. We will focus on a case study of two genetically and morphologically distinct wolf populations living in Eurasia. One of these survived the climate changes that have occurred over the past 40,000 years, whereas the other did not. We will describe the details of this extinction and replacement event, and determine the genetic processes that led to this difference between the two populations. To achieve this, we will carry out next-generation sequencing of wolf ancient DNA samples, and take advantage of ancient samples already collected and sequenced from across Eurasia. Together, this dataset will constitute the largest ancient wolf genome dataset ever collected. The project will end with a workshop that includes experts in climate and population viability modeling, and conservation practicioners, to explore the ways that the findings can be incorporated into future climate change mitigation planning. This workshop will provide new research avenues that the experienced researcher will be able to exploit in order to reach and reinforce a position of professional maturity and independence. The experienced researcher will also be trained in cutting edge scientific techniques and analyses, as well as a number of skills that are transferable between countries and sectors (including management, grant writing, communication and teaching), and that will facilitate his development into a research leader.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of in-vitro systems using human immortalised cell lines for testing skin irritancy' (1994-1998).

assistant: **Innovation**

The testing of cosmetological (and pharmaceutical) preparations will have to be performed in a near future by procedures alternative to animal experiments to comply with the Sixth Amendment (93-35-EEC) to the EC Cosmetic Directive (976- 768-EEC). In vitro recombined skin using human cells represents an elegant procedure for this purpose. The presently available models suffer imperfections that will be addressed in the present project to aim at the preparation of an in-vitro test for skin irritancy. It will display meaningful endpoints, should prove reproducible by the use of chemically defined culture products and immortalised cell lines and be easy-to-use by introducing adequate markers of the irritant reaction. The programme will be a shared activity of six academic research units representing a large part of the scientific european potential in the domain and associated industrial laboratories experts in the use of reconstructed skin for irritant testing. The project will be developed in four partially overlapping steps addressing to defined problems. Step 1- improvement of the quality of the stratum corneum in-vitro, introduction of endothelial cells in the dermal compartment and determination of in-vivo related endpoints of irritancy. Step 2 - replacement of the human cell strains by immortalised human cell lines and determination of the conditions required to obtain near physiological functions and the above determined selected end-points of the irritant reaction. Step 3 introduction of the markers of the irritant reaction by infection or transfection of constructions made of a reporter gene driven by the promoter of a protein participating in the process in the different lines of cells (keratinocytes, fibroblasts and endothelial cells). Step 4 - preparation of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Introduction of an online hydrogen sulphide analytic device for the creation of an efficient and economical and ecological sustainable waste water infrastructure in Europe' (2014-2020).

assistant: **Innovation**

Our waste water consists of many dissolved and undissolved substances from industrial, commercial and domestic wastewater. This results in a special environmental problem within the sewer: hydrogen sulphide (H2S).The effects of H2S are drastic. Economically very high infrastructure costs arise in our sewage system resulting fromsulphuric acid corrosion (investment needs Europe > 250 bn €). Ecologically it is proven that an increasing bulking sludgeformation results which is fatal for the microbiology in a sewage plant.In order to eliminate H2S, high amounts of chemicals are currently pumped through the European sewage system. But theuse of chemicals could be drastically reduced when measures would be taken already at the point of origin in the wastewater collection point, which prevent the H2S formation selectively. For this purpose, a measurement procedure isnecessary that can register on-site and online the H2S concentration.We, the ECH, have successfully managed to develop a new measurement method that is solving this problem. Objective ofthe SME Phase 1 is a feasibility study for an H2S analyzing device (TRL 6). Target customers are municipal and privatecompanies of the waste water industry, industrial sewage treatment plants, contract laboratories (market volume 200-500 m€). The advantages of the H2S-Analyzer are:Technology:- Measurement of smallest H2S incidences from 0,01 ppm- Fast measurements (<10 min)- automatized online measurementEcologically:- Proofed reduction of chemicals use for the treatment of H2S at least 40-50%Economically:- Reduction of expenditures for replacement investments in the waste water infrastructure- Cost savings of at least 40 % due to the low use of chemicalsThe H2S-Analyzer is as a key factor of the ECH and will lead to significant inc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Understanding the role of nuclear envelope proteins in the regulation of entiviral infectivity in non-dividing cells'.

assistant: **Objectives**

One of the most striking characteristics of lentiviruses and one that distinguishes them from onco-retroviruses is their ability to infect nondividing cells. As a result, primate lentiviruses such as HIV-1 can establish a productive infection in terminally differentiated cells such as macrophages and microglia in the brain or in memory T-cells that are not cycling. The prevailing view is that those viruses are indifferent to the cell cycle status of the target cells and can infect dividing and non-dividing cells indiscriminately. We have identified proteins of the inner nuclear envelope that are required for a step in the viral life cycle subsequent to nuclear entry but prior to integration of viral cDNA into host cell chromatin. Upon silencing these nuclear lamina proteins, the majority of viral cDNAs in the nucleus are converted to inactive circular forms. These results suggest a model in which nuclear envelope proteins counteract the action of enzymes in the nucleus that otherwise circularize and inactivate linear viral cDNAs. Because these inner nuclear envelope proteins are spatially disordered upon nuclear envelope breakdown at mitosis, our findings suggest that lentiviruses have evolved a specific route of entry into non-dividing cells.We have recently established that at least one of those nuclear lamina proteins is phosphorylated upon infection. Blocking phosphorylation resulted in the same effect as silencing the protein thus pointing at a complex regulation allowing nuclear entry. We propose to characterize the viral and cellular determinants that regulate this nuclear step in the viral replication cycle and further define how the inner envelope proteins regulate lentiviruses in the nucleus. We will extend our analysis to identify the cellular proteins and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantum magnetism in anisotropic dipolar systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

I propose to study the physical characteristics of anisotropic dipolar magnets as well as fundamental questions in the fields of quantum magnetism and disordered systems raised by recent experimental results obtained in these systems. Anisotropic dipolar magnets are central to the study of quantum magnetism and disordered systems. Better characterisation of the interplay between quantum fluctuations, effective random fields, hyperfine interactions and dipolar interactions in the non-perturbative regime, where they are comparable in strength, is essential for a proper description of the experimental results by correct effective models. A proper description will then facilitate a deeper understanding of fundamental problems in the fields of quantum magnetism and disordered systems, which, in turn, will lead the way to novel experimental directions. My expertise in the theory of disordered systems and quantum magnetism, in the analysis of experimental systems, specifically anisotropic dipolar magnets, and the connection between the two will serve me in pursuing this research. The proposed research is closely related to the research interests of Prof. Stamp of UBC and will thus enable me to maintain my scientific relations with the third country. The proposal relates closely to the interests of members of the condensed matter theory and experimental groups at Ben-Gurion University. Transfer of knowledge to the host institution and to the ERA will be facilitated by collaborations, seminars, supervising graduate students and teaching. Many theoretical and experimental groups in the EU have related research interests, and this proposal will serve to strengthen existing relations and to build new contacts within the EU. The EU reintegration grant will considerably enhance my pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Geoinformation technologies, spatio-temporal approaches, and full carbon account for improving accuracy of GHG inventories' (GESAPU).

assistant: **Concept**

Greenhouse gases (GHG) inventories contain ineluctable uncertainties, which cause serious difficulties: (1) The compliance with commitments to reduce GHG emissions is not solved, although for most countries the emission changes agreed on under the Kyoto Protocol are often smaller than the uncertainty in their estimated emissions. (2) Neither of the emission trading systems deals with the uncertainty of emissions estimates. Thus, decreasing inventory uncertainty is of paramount importance to its credibility, quality of compliance, and proper functioning of trading systems. The project aims in improving accuracy of the inventories in countries with differentiated regions and/or high coverage by forests, where the standard inventory procedures fail in producing high accuracy inventories. The proposed solution is to use spatially distributed inventories and more detailed forest modeling. This kind of inventory has been already compiled in Lviv Polytechnic for West Ukraine. It uses multilevel mathematical models, digital maps, georeferenced databases, and appropriate software. The objective is to develop similar spatial inventory of GHG emissions for Poland. To achieve the required spatial resolution, our method relies on statistical scaling models. Systems Research Institute contributes here with the expertise in statistical modelling. These methodologies will be novel in preparing GHG inventories. Further reduction of uncertainty is expected by modification and adaptation of the methodology for Ukrainian conditions, accounting schemes and models of verified full carbon account of forest ecosystems (FCA) developed by IIASA. Information background will be represented by a hybrid land cover as system integration of all available sources of information in GIS environment; with