RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'HumanE AI Network' (HumanE-AI-Net), addressing dissemination and exploitation.

assistant: **Impact**

The HumanE AI Net brings together top European  research centers, universities and key industrial champions into a network of centers of excellence  that goes beyond a narrow definition of AI and combines world leading AI competence with key players in related areas such as  HCI,  cognitive science, social sciences and complexity science. This is crucial to develop a truly Human Centric brand of European AI.  We  will leverage the synergies between the involved centers of excellence to develop the scientific foundations and technological breakthroughs needed to shape the AI revolution in a direction that is beneficial to humans both individually and societally, and adheres to European ethical values and social, cultural, legal, and political norms. The core challenge is the development of robust, trustworthy AI capable of what “understanding” humans, adapting to complex real-world environments, and appropriately interacting in complex social settings. The aim is to facilitate AI systems that enhance human capabilities and empower individuals and society as a whole while respecting human autonomy and self-determination. The HumanE AI Net project will engender the mobilization of a research landscape far beyond direct project funding, involve and engage European industry, reach out to relevant social stakeholders, and create a unique innovation ecosystem that provides a many fold return on investment for the European economy and society. We will  make the results of the research available to the European AI community through the AI4EU platform and a Virtual Laboratory, develop a series of summer schools, tutorials and MOOCs to spread the knowledge,  develop a dedicated innovation ecosystem for transforming research and innovation into an economic impact and value for soci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New production technology development for most efficient and more stable application of electro-optic and nonlinear optical crystalline materials' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main goal of this project is development of new production technology for most efficient and more stable application of crystalline materials as active elements of electro-optic or nonlinear optical cells, especially for control and/or conversion of superpowerful laser radiation. In the framework of such technol-ogy it is proposed to create new electro-optic interferometric setup and modernize existing nonlinear optical setup as well as to develope the necessary fundamental methodology being suitable for precise determina-tion and calculation of complete sets of electro-optic tensor coefficients or nonlinear optical second order susceptibilities in crystalline materials of different symmetry. Using these setups author plans to study the electro-optic and nonlinear optical characteristics of doped lithium niobate and borate family crystals or other low symmetry prospective inorganic/organic crystalline materials.  It is therefore expected to derive for these materials a complete tensor sets of electro-optic or nonlinear optical coefficients that will represent input parameters for further 3D-analysis of spatial anisotropy of investigated effects using constructed in-dicative surfaces and their stereographic projections. On this basis the global maxima of electro-optic or nonlinear optical effects for selected crystals will be determined and for these maxima their angular stability will be calculated using improved own software. In the final step it is planed to design the laboratory proto-type of such cell suitable for more efficient and stable control or conversion of superpowerful laser radiation made of mentioned above crystalline materials. Thus it will be a significant contribution in development of new production technology for most efficient and more stable ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Support action for innovation driven clusters in construction. Regional approaches, multi-stakeholder engagement and cross regional co-operation' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The driving idea of REG CON is the advancement of the concept of “R&D based clustering” across regions of Europe with a thematic focus on construction. This sector is both dynamic in creation of growth and employment [~7% of national employment/GDP, ~14% when add design and materials], but relatively backward in absorbing innovation. The Strategic Research Agenda prepared by European Construction Technology Platform set up ambitious but realistic goals to transform this traditional sector into the knowledge driven and R&D based. REG CON activities strength those goals from regional level. REG CON sets the following yardsticks of success and objective fulfillment:  Set up in the EU of three regional construction clusters and intense R&D activities of two existing one  Achieving cluster participant mobilization in each of the clusters, resulting to understanding of needs for each cluster actor, development of practical R&D action plans and co-operation.  Achieving nine instances of mentoring, cross- regional co-operation, SWOT analyze, joint R&D Action Plan and good practice transfer among the clusters and experts beyond the clusters. These would be implemented by: surveys, regional events and workshops, dissemination and mentoring activity.  Designing a financial instrument that would secure the sustainability of the clusters and R&D cooperation beyond the project lifetime.  Designing an administrative and management structure that would host and administer the cluster Project partnership is based on two advanced construction clusters from Finland & Slovenia [mentors] and three regions with “clusters initiatives” which need to be transform into clusters [Poland, Spain, Greece]. Each region involve main stakeholders: industry, research, local authorities. Partners in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nmr studies of zinc b-lactamases' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The most important mode of resistance to the B-lactam antibiotics occurs via their B-lactamase catalysed hydrolysis. B-actamases which require a zinc ion have received relatively little attention. Since they are resistant to inhibitors of the serine B-lactamases including clavulanic acid, the spread of zinc B-lactamase-mediated bacterial resistance to B-lactam antibiotics (including carbapenems) is frightening. In conjunction with an already existing european research project, we propose an NMR investigation of the catalytic mechanism of zinc B-lactamases. The Bacillus cereus zinc B-lactamase is expressed in E. coli and the very high yield of production allows 15N and 13C labelling of the protein. Labelled protein and its complexes with novel non-13-lactam inhibitors will be studied through Heteronuclear multidimensional NMR experiments to determine the implication of the highly conserved amino residues in the catalytic mechanism. As enzymatic activity is retained upon substitution of Zn by 1H-113Cd the role of the metal ion in the catalysis will be investigated through 1H-113Cd heteronuclear NMR. Training content (objective, benefit and expected impact) The success of the project will allow us to increase our knowledge of the still poorly understood catalytic mechanism of the zinc 13-lactamases, which represent a most important threat for the future of penicillin antibiotherapy. Links with industry / industrial relevance (22) As the design of new antibacterial compounds must rely on an improved understanding of the action of enzymes which inactivate the 13-lactam antibiotics, these studies will supply new ideas for the synthesis of potent inhibitors against the zinc 13-lactamases and new antibacterial agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'RAPID AND DURABLE ASPHALT ROAD REPAIRS 2' to be submitted under Horizon 2020.

assistant: **Abstract**

The overall objective of the project RADARR 2 (RAPID AND DURABLE ASPHALT ROAD REPAIRS 2) is to commercialize the unique microwave technology for asphalt roads repairs. The novelty of the technology lies in a completely new approach in pavement repair offering great advantages for various kinds of customers like maintenance companies, highway maintenance centres, regions and municipalities, associations of municipalities, private highway operators and construction companies. Microwave technology represents a revolution in asphalt road maintenance. It brings durable repair results, faster application and it is simple, more effective and economic in comparison with currently applied technologies. Application of the microwave technology enables elimination of non-homogenous connection of repaired spot resulting in significant extension of repairs life span. Extended life span of repairs means great savings for infrastructure owners and operators and consequently it means great market opportunity for FUTTEC Corporation. Another great competitive advantage of FUTTEC technology is the possibility of performing repairs during winter season, when competitive solutionsare highly limited by the weather and unable to offer qualitatively comparable results. Outcome of the project RADARR 2 will be tested microwave machine FT3 ready for commercialization. FT3 machine represents functional versatile device, which is using the microwave energy for repairs of cracks in asphalt surfaces (potholes) and is able to connect technological joints of new and repair asphalt using polymerisation agent. The machine will be adapted to customers’ needs and preferences in order to maximize the commercialization potential. The FT3 machine has the potential to change the approach of asphalt repairs and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Experimental study of interfacial processes - friction and lubrication' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The overall goal is attaining a microscopic-molecular level description of friction and lubrication. The study will focus on the characterisation of adsorbed organic monolayer subjected to compression and shear and on the relation between the chemical properties of the adsorbates and their functioning as boundary lubricants. The research will involve two experimental efforts: 1. Vibrational spectra of monolayers will be measured by Sum Frequency (SF) Spectroscopy. Vibrational spectra should reflect the structural changes within the monolayers following and during the application of compression and shear. 2. The single asperity aspect of friction of the same samples will be studied using Atomic Force Microscopy. Results are expected to shed more light on the relation between wear and adhesion, in particular under varying coverage of the surface. Trainings content (objective. benefit and expected impact) Both the subject and methods are novel, hardly studied in Israel and therefor new to me. I plan to return to Israel and implement my knowledge there. Links with industry / industrial relevance (22) The technological relevance of this project is widespread. Understanding the microscopic aspect of lubrication by organic monolayers can lead to improve lubricants and anti-wear agents, thus to enourmous economic benefits. While no direct involvement of industry is taking place, Dr Bain's group has long established links with Unilever Research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Modelling the impact of aging in sporadic Alzheimer’s disease'.

assistant: **Innovation**

Understanding therapeutic opportunities in Alzheimer’s disease (AD), the most common form of progressive neurodegeneration, is limited due to lack of animal models that replicate the disease’s consecutive stages. We achieved a breakthrough by xenografting human stem cell-derived neurons into mouse brains, where they integrate and survive up to two years, developing typical AD hallmarks. Neighbouring mouse neurons remain resilient to AD, underscoring unique human neuronal features not mirrored in rodents. Significant challenges persist, particularly modelling aging, the primary and most elusive risk factor for sporadic AD. The current model also lacks human microglia, crucial carriers of genetic risk for AD. We need to measure the impact of progressive disease on neuron function, as maintaining brain function is the ultimate goal. To address these challenges, we propose a novel method of transplanting human neurons that preserve their epigenetic markers of aging, together with human microglia in double xenografts. Concurrently, we will investigate neurons from healthy aging centenarians to understand the basis of AD resilience at old age. Our research tackles critical questions: (1) How do age-associated epigenetic changes modulate disease phenotype? (2) What is the molecular basis of resilience in centenarians? (3) Do newly discovered drug targets benefit neuronal function? (4) Which blood biomarkers track the effect of experimental treatments? This study focuses on human biology, using human cells, genes, and proteins, ensuring rapid translation to clinical settings. By the project’s end, we expect to identify at least four novel drug targets and their biomarkers, validated through preclinical studies. Developing the first animal models for sporadic AD is transformativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Strengthening of Cooperation and Exchange for Nuclear Education and Training between the European Union and the Russian Federation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The entire project of cooperation with Russia titled “Strengthening of Cooperation and Exchange for Nuclear Education and Training between the European Union and the Russian Federation” consist of two parallel projects on the EU side and the Russian side. The objectives of the entire project are:- based on the achievements of the FP7 ENEN-RU project, to further define a common basis for effective cooperation between the European and Russian networks for nuclear Education &Training (E&T);- to define a detailed implementation plan based on the needs of cooperation in the long-term agreed during the ENEN-RU project;- to solve the difficulties for cooperation found during the ENEN-RU project; to implement the plan in a sustainable manner;- to operate the knowledge management framework;- to list up and promote further use of E&T facilities, laboratories and equipments.Based on the achievements of the FP7 ENEN-RU project, the ENEN-RU II project will further develop the framework of cooperation between the EU and the Russian Federation in terms of Nuclear Education and Training. It includes further analysis of short-term and long-term manners of cooperation, define opportunities and barriers for cooperation, and organise exchange courses and training sessions with EU and Russian participants during the project. The project will provide the basis for mutual recognition of the E &T programmes on both sides and expand the scope of the students, researchers and young professionals exchanges. This would offer to nuclear research institutes and industry a broader basis of human resources and foster cooperation in nuclear power development. The focus of the project is on the Master level and postgraduate education, and on Training for young professionals. The overall management of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Release of engineered extracellular vesicles for delivery of biotherapeutics'.

assistant: **Concept**

Nucleic acid-based medicines have opened a new avenue in drug discovery to target currently undruggable genes and to express therapeutic proteins, unlocking novel therapeutic options for a range of diseases, including neurodegeneration. However, they need to be encapsulated in nanocarriers to ensure their stability and efficient uptake into cells and tissues. Synthetic nanoparticles based on cell-penetrating peptides (CPPs) and, particularly, lipid nanoparticles (LNPs) have recently emerged as potent vectors for hepatic delivery. However, these systems fail to robustly target other organs in a safe manner. Another promising nanocarrier for advanced drug delivery is extracellular vesicles (EVs) that have the ability to efficiently convey macromolecules into cells. As native nanoparticles, EVs benefit from immune tolerance as well as the ability to cross biological barriers to reach, for example, the brain. We have developed advanced strategies to bioengineer cells to generate EVs loaded with therapeutic RNAs and proteins. However, their production at scale is cumbersome and time consuming.Here, I propose a platform development using synthetic nanocarriers to transiently engineer hepatic cells in vivo and harness EVs to functionally DELIVER biotherapeutics to currently unreachable, distant organs, focusing on brain. To achieve this, genetic constructs will be developed that allow for transient in situ engineering of cells in vivo and release of cargo (e.g. CRE)- laden EVs, displaying CNS-specific peptides, that can be functionally transported to distant organs, including brain. We will exploit the same strategy using CPP-based nanoformulations, recently developed in my lab, injected locally in brain to secrete EVs loaded with the disease-relevant protein GBA1 as a treatme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A Coherent Analysis Framework for Emergence in Biological Systems'.

assistant: **Innovation**

This network will provide a rigorous training in solving complex problems in the context of emergence in biological systems, combining approaches from many scientific traditions. A major scientific challenge lies in understanding how dense many-body systems with complex interactions behave at the macroscopic scale under noisy non-equilibrium biological conditions. A coherent framework for performing such an analysis, grounded in the principles of statistical physics, demands an integration of multiple approaches that are currently applied in isolation and in a fragmented fashion. This network will build this coherence, by bringing together multiple partners with substantial complementary expertise, and through individual research projects that are each designed to combine this expertise in fundamentally new ways. Through this, we will gain new understanding of the novel physical interactions that biological systems create, establish quantitative relationships between microscopic interactions and macroscopic collective effects, and confront the complexity of real-world systems through data-driven modelling and experimental applications. This new understanding has a range of important applications, including cancer growth, cardiac health, biofilm formation and animal fertility.The research training will be complemented by professional training in advanced digital skills, such as software and data carpentry, as well as in entrepreneurship, communication and public engagement, much of which will be delivered through non-academic partnerships. All doctoral candidates will complete academic or non-academic secondments for a substantial period. These experiences will fill transferable skills gaps in traditional doctoral research training, and build doctoral candidates’ career