RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regulating private primary care for more sustainable, equitable and efficient health care provision: is contracting-out the solution for central america' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Most of Central American health systems are fragmented. There are various sectors, including often-unregulated private healthcare, providing first line health services with different access, quality and range of activities. This leads to problems of equity and efficiency. Contracting out is fashionable in Central America to improve State regulation of private providers. This concerted action will build an analytical framework of local experiences of contracting private first line health services by public actors. One of its main feature, will be to describe the effects of contracting on sustainability, equity and efficiency in the provision of services on the base of the perception of target population, in addition to those of public purchaser, and private providers. The final aim of this framework is to strengthen the state by giving better capacity of policies adaptations to regulate private providers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification of TILs-specific novel lincRNA and their functional importance in mediating immune response in renal cell carcinoma' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

One of the top ten tumors that occurs worldwide most commonly is renal cell carcinoma (RCC) and its incidence is increasing. Regulatory T cells (Tregs), expressing transcription factor FOXP3, play a critical role in the suppression of inflammatory responses maintenance of self-tolerance. However, within the TME, Tregs contribute to tumor development and progression by reducing antitumor immune responses and promoting tumor growth. The dysregulation of specific lncRNAs has been correlated with the prognostic outcomes of patients with RCC, whereas the lncRNA dysregylation in tumor infiltrating lymphocytes is unclear. The overall objective of REGULINC is to increase our understanding of the role of both known and novel lincRNAs in governing the function of regulatory T cells (Tregs) present in the tumor microenvironment (TME) of RCC. This study will identify for the first time the TILs-specific lincRNAs  with a focus on Tregs, and their role in Treg interactions with other immune cells in RCC samples. REGULINC will probe into the role of novel lincRNAs in the stability of Tregs and their cell-suppressive capacity, and ascertain if modulation of selected lincRNAs could result in enhanced immune response by TILs in the TME. The project will gain new mechanistic understanding of how lincRNA network defines Tregs activity in TME of RCC. It will also develop novel tools for therapeutic intervention through specifically targeting immune-suppressive Tregs to boost immune response in the TME of RCC.


**Keywords:** long non-coding RNA, Tregs, TILs, CRISPR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative STATOR' (InnoSTAT) under Horizon 2020.

assistant: **Objectives**

The noise reduction measures for engine related noise from the intake, but also for rearward radiation is highly targeted during the last 15 to 20 years. Most effort has been made in passive technologies for intake liner concepts, but also for the low noise design of fan and stator blades. From all the current available technologies a noise reduction related to engine sources by 6 dB can be expected, which is a big achievement, but still does not suffice to reach the goals. Thus, a further refinement of possible technologies has to be re-opened, like in the case of innovative stator technology. The proposed work of InnoSTAT consists in a systematic procedure, which has not been performed yet for considered OGV technologies. InnoSTAT will be the first project where the activities are focused on the above process with the only goal of bringing at least 3 OGV concepts to demonstrator level at TRL3 on full scale. This has not been achieved yet in any other programme for one OGV concept. The project’s objectives are• to define 5 novel low noise stator concept designs, to develop and test them on prototype level TRL2 to TRL3,• to select and develop 3 novel stator concepts for further advanced design, characterisation and full 3D stator stage large-scale testing of 2 OGV stages to TRL4,• to define, design and manufacture 1 demonstrator OGV at TRL3 on full-scale.The project’s goal will be achieved in 3 major steps by 1) testing and improving the technologies 5 concepts on small-scale prototype level, 2) down selection of 3 technologies for further test of two of them on large-scale, each as a fully equipped stator stage, and 3) finally 1 selected concept demonstrator to be manufactured and perform an integration study regarding engine environment.This 51-months project with its
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Enriched Minimal Expressivism and Higher-Order Concepts' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

One (unum), True (verum), and Good (bonum), the Medieval transcendentals, are concepts that philosophers have always kept at the centre of their concern, as has occurred with logical notions such as therefore, epistemic notions such as knowledge and belief, and deontic notions such as ought.  And for good reasons. The meaning of these concepts is complex, and language sciences have needed a sophisticated degree of development to be able to cope with this issue. All these notions encode what we now call “higher-order concepts”. The defining characteristic of higher-order concepts is that they are predicative notions that have other predicables (including 0-adic predicables, i.e. propositions) as arguments. Logical constants, quantifiers, and alethic, epistemic, and deontic modalities belong to the general class of high-order concepts. EMEHOC aims at developing a unified and comprehensive treatment of higher-order concepts, Enriched Minimal Expressivism, which benefits from the several insights that philosophers have put forward related to some particular sets of them, and also of the latest linguistic proposals on procedural and non-truth-conditional meaning. EMEHOC will develop the first-ever general theory of higher-order concepts. To date, philosophers and linguists have given some useful insights on them but EMEHOC will be the first to examine their functioning from an interdisciplinary perspective. EMEHOC’S impact will reach any areas of knowledge in which accurate discourse and precise argumentation are essential. This includes ethics and political theory, and in general public and scientific uses of language.EMEHOC will use a collaborative methodology that will contribute to the emergence of new, promising interdisciplinary areas, according to the objectives of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The origins of dendritic computation within mammalian neural circuits' to be submitted under Horizon 2020.

assistant: **Abstract**

This proposal aims to address a simple question: what is the fundamental unit of computation in the brain? Answering this question is crucial not only for understanding how the brain works, but also if we are to build accurate models of brain function, which require abstraction based on identification of the essential elements for carrying out computations relevant to behaviour. In this proposal, we will build on recent work demonstrating that dendrites are highly electrically excitable to test the possibility that single dendritic branches may act as individual computational units during behaviour, challenging the classical view that the neuron is the fundamental unit of computation. We will address this question using a combination of electrophysiolgical, anatomical, imaging, molecular, and modeling approaches to probe dendritic integration in pyramidal cells and Purkinje cells in mouse cortex and cerebellum.We will first define the computational rules for integration of synaptic input in single and multiple dendrites by examining the somatic and dendritic responses to different spatiotemporal patterns of excitatory and inhibitory inputs in brain slices. Next, we will determine how these rules are engaged by patterns of sensory stimulation in vivo, by using various strategies to map the spatiotemporal patterns of synaptic inputs onto single dendrites. To understand how physiological patterns of activity in the circuit engage these dendritic computations, we will use anatomical approaches to map the wiring diagram of synaptic inputs to individual dendrites. Finally, we will perturb the dendritic computational rules by manipulating dendritic function using molecular and optogenetic tools, in order to provide causal links between specific dendritic computations and senso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'THE ROLE OF UBIQUITYLATION AND DEUBIQUITINATION ENZYMES IN CANCER' (UBIQCANCER).

assistant: **Concept**

The overall goal of my research is to identify and characterize genetic factors leading to tumor development in human by establishing mouse models for development of anticancer drugs. The objective of the present study is to understand the function of ubiquitin ligation enzymes and deubiquitin enzymes during progression of different human skin cancers. This is analysed by generating transgenic animals and applying tumour-promoting protocol to specifically dissect the role of these enzymes during progression of cancer on mouse skin. During the proposed studies, mice deficient in various ubiquitin mediated signaling molecules such as CYLD and Bcl-3 will be used to test their contribution to cancer development. In addition we will identify novel E3 ligation and deubiquitination enzymes involved in progression of skin cancer using a multidisciplinary approach that combines mouse genetic, masspectrometry in vivo and gene expression profiling. To correlate information obtained from animal model to the development of treatments of human cancer, we are generating human tissue platforms from skin cancer patients regenerated on immune deficient mice. This model enables to study human epithelial neoplasms under in situ conditions. The results obtained in the transgenic animals as well as human tissue platform are correlated and compared to the samples from melanoma and non-melanoma human cancer patients. Furthermore, transgenic animals and transplanted human tissues are treated with proposed drug before tumor induction to test their specificity. Using state-of-the-art approaches and techniques, this project will identify novel markers for improved diagnosis and validation of candidate drug target for skin cancer therapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High-temperature Thermophoresis using advanced optical microscopies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Thermophoresis denotes the motion of dissolved species in fluids created by temperature gradients. In water, the origin of thermophoresis is multiple, complex and still a matter of active research activities for solutes such as proteins, DNA or colloids.Thermophoresis at small scales (sub-100 µm) aroused a strong interest this last decade because it makes the process faster and because of the development of important applications in life sciences, e.g. in bioanalytics. However, reducing the spatial scale makes quantitative and non-invasive measurements of temperature and molecular concentration more challenging.In the HiPhore project, using gold nanoparticles under illumination as nanosources of heat, I wish to achieve major breakthroughs in the field of microscale thermophoresis in liquids (MTL): (i) We will develop new microscopy tools and pioneer their use in the context of MTL: we will implement the possibility to shape arbitrarily complex microscale temperature profiles and to quantitatively image in parallel the resulting fields of temperature and molecular concentration using label-free advanced optical tools. (ii) Thanks to these tools, we will study the enigmatic origin of protein thermophoresis with a new glance. We will also explore a new regime, that I coin super-thermophoresis, consisting in thermophoresis in superheated liquid water up to 200°C. We have shown that such a metastable state can be achieved at ambient pressure using gold nanoparticles under illumination at their plasmonic resonance. (iii) Based on this gain of knowledge and know-how, we will develop two new applications of MTL. The first one consists in studying the thermal stability of proteins by thermophoresis with a label-free approach. The second one consists in using a superthermophoreti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Continuous simulation of electromagnetic compatibility (emc) in automotive application cosime""' to be submitted under Fifth Framework.

assistant: **Abstract**

Innovations in the automotive area are rendered essentially through new electric systems. This leads to higher electromagnetic noise emission. In this project a new continuous EMC-simulation process will be defined. This process is based on the exchange of EMC-simulation models between car manufacturer, electronic supplier and IC manufacturer. In this way, in a very early stage of the development process new concepts (e.g. for 42V) can be evaluated using simulation. Three main tasks are carried out in this project: 1. Defining EMC-behaviour models for automotive application 2. Developing an EMC critical test set-up using the new EMC-design process 3. Developing new EMC-design concepts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Development of innovative tools for minimal surgical procedures'.

assistant: **Concept**

The proposal is to develop innovative tools for minimal invasive surgery (MIS). The tools used are primitive in their concept, extremely costly, mostly disposable, and are not designed to take maximum advantage of the knowledge, characteristics and skills of the surgeon. There is a need to develop more effective and safer tools which can bring distinct advantages in terms of operating times, precision, safety, effectiveness and in the training of surgeons.The objectives are:1. To develop a range of surgical tools for MIS operations which overcome the deficiencies of existing tools;2. By innovative design to gain economies with respect to theatre time, reduction in errors, training of surgeons and hand tool costs;3. Incidentally, to set the basis for minimum qualifications for surgeons involved in the use of surgical tools in MIS. The proposers have considerable experience in the design of hand tools that maximally exploit basic human characteristics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'A RAPID HAND-HELD ANALYSER FOR CONTROL OF MICROORGANISMS IN THE COMPLETE MEAT SUPPLY CHAIN'.

assistant: **Objectives**

Foodborne pathogens in processed ready-to-eat products pose a serious threat to consumers with compromised immune system. Sensitive, specific and rapid detection of such pathogens is thus essential at production level to prevent their entrance into the human food chain. Conventional microbiological detection methods simply take too long (2 to 7 days) to detect and identify pathogens in food and no real time data is available. Other traditional testing methods, such as ELISA, are also relatively costly and time-consuming. Traditional methods require the taking of a product sample, its posterior culturing until sufficient microorganisms have been generated to enable ready detection on culture plates. While a number of methods such as PCR may provide faster detection (6-12 hours) they involve complex procedures and highly specialised trained personnel. In today's modern food supply chain, products enter and leave the market within two to three days. Slow traditional analytical methods are clearly deficient as they enable contaminated meat products to reach the market, resulting in human disease and even mortality. Moreover, most analyses need to be carried out in large analytical laboratories as the required instrumentation is expensive and requires highly qualified staff. Only very large farms and slaughterhouses can thus afford to perform regular, on-site, microbiological checks. There is a clear need for a rapid, handheld, easy to use and cost effective microbiological analyser which is tailored and well suited to the needs of the meat industry to enable its use on the processing floor thus allowing rapid process control testing. A biosensor based approach presents a promising and sensitive alternative tool for the detection of low numbers of cells in a question of minu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Global and local impacts on Atlantic RHODOlith beds: Implications for estimates of blue CARbon ecosystem services' under Horizon 2020.

assistant: **Concept**

Rhodolith beds are one of the most extensive benthic ecosystems along the Atlantic coasts and key environments to continental shelf resilience. Besides providing substrate and habitat for numerous other algae and sessile invertebrates, their ability to calcify, their high abundance and biomass, makes rhodoliths major carbonate producers. Recent empirical estimations suggest that the carbonate marine deposits generated by these organisms represent a total potential carbon sink of 0.4 x 109 t C yr-1. Hence, giving the increasing role of marine ecosystems in the storage of blue carbon, rhodolith beds may represent a not yet considered significant carbon store. Regarding carbon sequestration, studies on rhodolith bed community metabolism are scarce and so far only available for two temperate beds that indicate that they can act both as CO2 source and organic carbon sink. As many marine ecosystems, rhodolith beds are currently under threat related to global climate change (GCC), with local impacts due to increasing coastal urbanization, potentially lowering even further their resilience. Thus, by using a physiological approach, this project will provide much needed information on the basic mechanistic understanding of rhodolith metabolism (photosynthesis, calcification), rhodolith responses to global and local stressors, and rhodolith bed community metabolism and carbon storage along a latitudinal gradient. Taken together, this information will allow assessing the importance of rhodolith beds as natural carbon sinks, thus, help ascertain whether these ecosystems meet the requirements to be integrated into climate mitigation policy, and will further allow quantifying the effects of GCC on their carbon sequestration and storage ability. In addition, it will help recognizing po