RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Add-on module for optical coherence tomography with en-face view option' (AMEFOCT), addressing dissemination and exploitation.

assistant: **Impact**

By the end of the 4th year of the ERC Advanced grant, the PI has set up the basis of a unique procedure to perform optical coherence tomography (OCT) that is similar in outcome to time domain interferometry but has all advantages of spectral domain interferometry in terms of speed and sensitivity. The new method of OCT, termed as Master/Slave (MS), is characterised by several advantages: direct production of an en-face OCT image, tolerance to dispersion that allows MS-OCT to achieve the theoretical limit of axial resolution and sensitivity that can be tailored for no hardware and time cost, with the axial resolution. By excellence, the Master/Slave OCT method delivers en-face views direct, allowing lower cost hardware and faster provision of en-face slicing and visualisation. An essential advantage is that of parallel processing, that makes MS-OCT, ideally suited to novel parallel optical configurations and graphic processing units (GPU). These advantages can substantially increase the speed in providing volumes of the tissue, making the new OCT method superior to all other methods on the market. The POC support will help advance the MS-OCT closer to commercialisation. Four market strategies are identified with immediate products for the first two. OCT add-on modules, equipped with MS software, for: A. OCT developers, to accelerate their research and B. OCT developers that can modify existing commercial OCT systems, by making them accomplish the MS protocol. The module to be assembled and assessed for commercialisation will also pave the way to two more strategies: C. Companies already selling OCT systems on dedicated markets, where specialised agreements will widen the market and even D. A full OCT system created by the new company, an ultimate outcome that requires in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Agricultural-climatic interactions on the control of stream dissolved organic matter trends' in the context of a Horizon Europe call.

assistant: **Objectives**

The rising trends in terrestrial dissolved organic matter (DOM) concentrations in streams have become a serious environmental issue in many catchments of the northern hemisphere. Indeed, DOM impairs water quality and affects the biogeochemical and ecological functioning of aquatic ecosystems. Knowledge gaps in drivers controlling seasonal and interannual variations of stream DOM limit our ability to provide measures that may be implemented by decision makers in order to mitigate the continuing trends. In rural landscapes, agricultural practices interact with climatic drivers to affect biogeochemical cycles, however these interactions and their impacts on stream DOM dynamics over different timescales have not been considered so far. The ambition of COSTREAM is to provide a better understanding of the linkages between management actions and stream DOM variability both spatially and temporally in order to enhance science-based management and restoration solutions. The project will combine field and experimental studies in a well-equipped agricultural catchment with data mining of long-term records collected in the French Brittany region. The main objectives are 1) to investigate the impact of nitrogen mineral fertilizer on the production of terrestrial DOM at the seasonal scale, and 2) to determine how land use management plans during the last decades have interacted with shifts in climatic drivers to regulate stream DOM patterns at the regional scale. The COSTREAM project has potentially strong impacts on both scientific and societal perspectives. Thanks to this project, the experienced researcher will receive a unique multidisciplinary scientific training by INRAE that will reinforce significantly his expertise for future research activities and open new perspectives for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Life-history genes in fishes: bridging functional and evolutionary genetics for understanding life-history trait evolution' (FishLEGs) under Horizon Europe.

assistant: **Objectives**

Life history is one of the most central concepts in biology. Numerous biological questions ultimately revolve around the causes and consequences of variation in reproduction and survival i.e. fitness. Tremendous effort has been put in establishing the causes and mechanisms for life history trait variation and trade-offs. But even in well studied model organisms, evolutionary genetic and functional genomic approaches are rarely combined, and thus the path from genotype to phenotype often remains a black box. A strategy to overcome this major hurdle has recently emerged, with the discovery of loci that explain exceptionally large proportions of the variation in various life history traits. These “life-history genes” offer new opportunities to study not just the why (evolution) but also the how (functional genetics) of life history trait variation. I will address critical outstanding questions by bridging functional and evolutionary genetics approaches to study multiple loci linked with life-history traits including age at maturity, migration timing and migration strategy in 3 fish species: Atlantic salmon, Rainbow trout/steelhead and Atlantic cod. The relatively simple genetic architecture of the traits, combined with the features of these species as model systems, offer a unique opportunity to finally reveal the genetic architectures, molecular mechanisms and ecological drivers that translate large-effect genotypes into adapted life history phenotypes, and examine how evolution shapes these processes. In FishLEGs I will: i) characterize the molecular functions behind genotype-life history associations; ii) elucidate life history trait reaction norms and evolution in variable environments and iii) determine the strength of natural and sexual selection on life history trai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exploring cell interactions in the tumor microenvironment with dual ribosome profiling' (DualRP).

assistant: **Concept**

Cancers develop in very heterogeneous tissue environments. They depend on the tumor microenvironment (TME) for sustained growth, metastasis, and therapy resistance. Stromal cells are genetically stable and they have less likelihood to develop resistance than cancer cells. Therefore, targeting the TME represents an attractive approach for treating cancer. In order to develop new therapeutic strategies to reprogram the TME and inhibit tumor growth and resistance, it is essential to understand in detail the molecular mechanisms of the interactions between cancer and stromal cell populations. However, current methods to study these interactions require complete dissociation of the tumor, exposing the cells to severe stress and affecting dramatically gene expression patterns. Here, I propose to use Dual Ribosome Profiling (DualRP), a system that I recently developed, to study cell interactions in the TME. DualRP is an approach that allows not only simultaneous analysis of gene expression in two interacting cell populations in vivo, but also is able to uncover metabolic limitations in tumors. I aim to apply DualRP to mouse xenograft models where cancer cells interact with non-transformed fibroblasts and I’ll explore the combined response of both populations to cancer therapy. Moreover, I’ll utilize mouse genetic models tailored for DualRP to study cancer cell and macrophages/endothelial cells interactions. I will employ a combination of mouse genetic models, biochemical tools, deep sequencing, and bioinformatics. These studies will provide insight into how gene expression and metabolic programs define the interaction between cancer and stromal cells to promote tumor growth and metastasis, identify potential targets for therapeutic intervention, and provide maps of cell intera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Nutritional ecology and seasonal colour polymorphism in a butterfly'.

assistant: **Innovation**

Large colour ornaments such as bright plumage in birds or vivid wing coloration in butterflies are some of the most intriguing phenomena in the natural kingdom. However, the selective pressures and constraints involved in the evolution of these traits are in most cases poorly understood. Here we posit that evaluating the underlying nutritional demands of large colour patterns promises to provide novel insights in to the evolution of colour traits. Colour patterns can represent surprisingly large pools of specific nutrients. For example, male Cabbage White butterflies (Pieris rapae) invest as much as 15% of their total adult nitrogen in wing pigmentation alone. However, despite the substantial resource draw that many colour patterns impose on their bearers and the potential importance of these resource demands to other morphological and life history traits, the nutrient dynamics underlying production of colour traits have rarely been considered in studies of their evolution. We will evaluate the importance of nutrient ecology in the evolution of the distinct seasonal colour forms of the European Map Butterfly, Araschnia levana. This butterfly exhibits an orange, ommochrome-dominated spring form and a black-and-white, melanin-dominated summer form. These two colour forms differ substantially in the nutrient demands they impose, with the former requiring large amounts of tryptophan, whereas the latter requires large amounts of phenylalanine and/or tyrosine. In order to better understand the evolution of this colour polymorphism, we will evaluate seasonal differences in nutrient availability, acquisition and allocation. We will also explore the role of hormonal control in mediating nutrient-based life history tradeoffs associated with these two distinct colour phenotypes. W
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Gaming for Peace' (GAP).

assistant: **Concept**

EU Personnel in Conflict Prevention and Peace Building missions come from diverse organizations and nations, yet must coordinate together in the temporary network or umbrella organization that comprises each CPPB mission. Coordination is challenging strategically and operationally. Even if the structures to coordinate together are in place, diversity in organizations (militaries, police forces, civil organizations), gender and culture (national, ethnicity,  religion) make understanding of diverse personnel, and effective communication and cooperation in contexts of diversity difficult yet vital in order to achieve CPPB missions' goals. Current training puts few resources into training personnel in these critical soft skills. Gaming for Peace (GAP) provides an efficient and effective means of developing and delivering a curriculum in those skills. Deriving a base curriculum from CPPB relevant soft skills and end user identified training gaps in this area, GAP designs a multiple player online role playing game which simulates scenarios from CPPB missions. The GAP project launches an iterative process of curriculum development and refinement through end users (military, police and civilian personnel)  evaluating the game and embedded base curriculum by playing the game and in doing so, bringing their own experiences to the game, thus further developing the curriculum of CPPB relevant soft skills. The game can be accessed anywhere via the Internet and there is no limit on the number of personnel who can be trained. The game can be customized at low cost by different stakeholders. The GAP consortium is multidisciplinary with expertise in the social sciences, computer science, end users (including militaries and police), and SMEs in game design, curriculum development and ski
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INnovative TEchnologies and Researches for a new Airport Concept towards Turnaround coordinatION' (INTERACTION).

assistant: **Innovation**

INTERACTION proposes an evolution in airport operations towards a fully integrated and coordinated management of all the processes-passenger, baggage, freight and ramp operations-which are converging into the aircraft turnaround. The main needs are 3: increase time efficiency in each one of the airport processes and the turnaround itself in a coordinated way; reduce the environmental impact of the turnaround; and enhance the predictability in the turnaround operation and its associated processes. This new concept will be supported by a set of innovative solutions for each of the airport processes and considering an integrated vision of them. Innovative solutions will be grouped in three areas: advanced procedures and new operational concepts; innovative technologies and techniques; and enhanced information management and decision support tools. A new integrated management approach will be presented, based in a comprehensive analysis addressing all airport processes impacting the turnaround and driven by the following innovative enhancements: Coordinated definition of performance targets among processes towards common operational goals for the turnaround; Control and efficient management of existing process’ interactions and cross-relations in order to avoid undesired perturbations; Integration and adaptation of the individual milestones of each process into the turnaround milestones; Extension of the airport information sharing platform, in terms of scope (all processes included) and service continuity (real time information); New decision support functions providing alerts and warnings regarding all processes and its interactions. All airport stakeholders involved in the turnaround will be benefitted from INTERACTION results: airport operators, airlines, ground handler
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mass loss in the lives and deaths of massive stars' (StarlightWinds).

assistant: **Concept**

Across our Universe, the dynamics and chemical evolution of spiral galaxies like the Milky Way are primarily controlled by the lives and deaths of stars with masses many times that of the Sun. But the evolution of these massive stars is, in turn, highly regulated by the huge amounts of mass lost from their surfaces, by means of powerful starlight-driven winds. These stellar winds critically determine how such massive stars evolve through their lives, and how they finally die in giant supernova explosions. However, due to the very large quantitative uncertainties associated with this mass loss, present-day predictions for such massive-star evolution are seriously flawed.  The overarching goal of this ambitious project is to fundamentally improve this situation by using novel methods to develop new models of radiation-driven winds from hot, massive stars. Combining state-of-the art numerical NLTE radiative transfer and hydrodynamics with innovative analytic techniques and theory development, the applying researcher proposes to 1) develop new, drastically improved wind models from main-sequence massive stars, and 2) simulate the winds of the most massive stars known in the Universe as well as design the very first general predictive theoretical framework for the wind driving and mass loss from evolved Wolf-Rayet stars.  By furthermore examining the effects of the new mass-loss rates on models of stellar evolution, and carefully comparing the new simulation results with observations, this project will fundamentally improve our knowledge of the basic wind-physics of massive stars, as well as significantly contribute to our understanding of the evolution and ultimate fates of these stars. Indeed, the results expected during the fellowship will undoubtedly form the building bl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Soft Enforcement of EU Migration Law' (SoftEn).

assistant: **Concept**

This project will establish soft enforcement of EU migration law as a new research field in which legal and political science scholars will be equally active. Migration is a salient issue for the EU, and we are witnessing deep shifts in the implementation and enforcement landscapes of EU migration law. Traditional enforcement methods, such as Court of Justice proceedings initiated by the European Commission against Member States, have met their limit. Soft enforcement is becoming a flexible and politically palatable alternative. For example, Fundamental Rights Offices have been established within EU migration agencies that operationalise novel Ombuds-type administrative accountability processes, and a peer review mechanism, run jointly by the Commission and Member States, has been integrated with the Schengen area of free movement.   SoftEn conceptualizes soft enforcement and unlocks the black box of its operationalisation in the context of migration. It brings together theoretical insights from legal and political science on governance, enforcement, and accountability, combining legal analysis with empirical qualitative methods. Its groundbreaking nature lies in three characteristics. First, the project will generate a new interdisciplinary, legally grounded and empirically informed theory of soft enforcement in the migration context. Second, it will generate datasets on soft enforcement along three axes (steering policy implementation; supervising policy implementation; and ensuring actor accountability) across the EU’s migration policies. Moving beyond ‘law on the books’, it will also generate unique qualitative empirical insights at EU and selected national levels. Third, it will generate a new evidence-informed governance framework for soft enforcement that can imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Exploring ’synthetic lethality’ and ’synthetic viability’ to elucidate responses of breast and prostate cancer cells to DNA damage and treatment resistance'.

assistant: **Objectives**

The key objective of this Marie Curie project is to explore the ‘synthetic lethality’ and ‘synthetic viability’ principles applied to DNA damage response (DDR) mechanisms and help derive new therapies and/or biomarkers for personalized treatment of breast and prostate cancer. As these tumors are major causes of mortality and morbidity in Europe, and this multifaceted project in an outstanding host environment provide unique opportunities for training, this ‘SYNvia’ proposal directly addresses the prevailing medical needs and issues relevant for this Work Programme. The emerging potential of drugs/inhibitors to block certain DDR pathways is illustrated by the successful clinical trials with PARP1 inhibitors on BRCA1/2-deficient breast/ovarian tumours. This documents the power of combined interference with different DDR processes: ‘synthetic lethality’ (synthesis of cancer-specific defect of one DNA repair pathway with a drug to inhibit another repair mechanism) to combat cancer. The host laboratory made several discoveries in the DDR/cancer field, including examples of synthetic lethality, and contribution to the first example of synthetic viability, the latter causing resistance to cisplatin or PARP inhibitors in BRCA-defective cancers through loss of 53BP1. Here, we will use high-content siRNA-based functional screens to pinpoint novel synthetic viability and lethality combinations of the down-regulated genes with promising inhibitors of, respectively, PARP1 or the key DDR kinases ATM, ATR and DNA-PK. A range of cell and molecular biology and imaging methods will serve to validate selected combinations, combined with mouse xenograft experiments and tumour microarrays to test candidate biomarkers. As all tools and methods are available, this ambitious project is feasibl