RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Assessing transcriptional and nuclear pore aging in age-equivalent and rejuvenated induced neurons from Alzheimer patients' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

I am a stem cell biologist specialized on modeling human neurodegenerative diseases. During my PhD with Dr. O. Brüstle (University of Bonn), I was trained in human stem cell and reprogramming technologies working on human models for Alzheimer’s Disease (AD). As a postdoc at the Salk Institute with Dr. F. H. Gage, I acquired and strong foundation in functional neuroscience, nuclear pore biology and systems biology/bioinformatics. My work helped to better understand complex neuropsychiatric disorders, as well as the process of neuronal aging. I could show that direct conversion of human fibroblasts into induced neurons (iN) preserves signatures of cell aging, while iPSC reprogramming erases them. To start my own independent lab, I have accepted a tenure track position at the University of Innsbruck. As an independent scientist, I seek to bring together my recent findings on reprogramming and aging, my permanent interest in AD, and powerful systems biology and bioinformatics to unravel the age-dependent disease-initiating mechanisms of sporadic AD. In this proposal, I, together with my supervisor Prof. Dr. Frank Edenhofer, designed a dedicated research and training plan. In the first aim of the project, I will generate phenotypically old (iN) and rejuvenated (iPSC) neurons from an established set of well-characterized AD patients and controls. Using unbiased transcriptome approaches, the data will help to better understand the impact of neuronal aging on sporadic AD pathogenesis. In a second aim, I will use live-cell imaging approaches to study the age-related dysregulation of nucleo-cytoplasmic transport. The goal is to better understand how cellular aging affects pathogenesis, in order to pinpoint the earliest and potentially most treatable mechanisms involved in AD. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EEN InnoSupp BG' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The main objective of this project is to contribute to the implementation of the European policies in the field of innovation management capacity building in SMEs and their implementation in Bulgaria, resulting in effective and efficient investments in novelties leading to growth and quality jobs. As a major tool for improving global competitiveness of European companies, implementation of novelties in products, processes and society needs specially devoted attention and resources.This project will contribute to the better filtering and acceleration of innovation processes in Bulgarian SMEs, thus supporting growth and jobs. Supported companies are supposed to be better prepared for using Access to Finance instruments and attract investments in innovation.


**Keywords:** innovation management, innovation, KAM, SMEs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Evolutionary and ecological causes and fitness consequences of dispersal strategies and cooperative breeding in pre-industrial people'.

assistant: **Innovation**

The aim of this proposal is to investigate how evolutionary theory that applies to cooperative birds and mammals can explain the incidence of family living and cooperative breeding in pre-industrial humans. Such theory suggests that (1) families evolve when adverse ecological conditions render offspring dispersal costly and philopatry beneficial, and (2) cooperative breeding evolves when delayers can accrue fitness by helping.   Hypotheses will be primarily tested using data from pre-industrial Finns, but will be supplemented with similar data from Canadians and contemporary Dominicans. The data on Finns has been collected on a range of life-history (births, deaths, marriages, dispersal), ecological (weather, climate, harvest yield, famine, war) and social (class) variables for more than 2000 families from five different areas in Finland. The data is restricted to the pre-industrial era (1720-1900) when mortality was high and fertility natural.   This project will consequently result in the most comprehensive analyses yet conducted on this subject in humans, and aspects will rival the quality hitherto reserved for a few species of cooperative birds and mammals. It is proposed that powerful techniques of mixed and matrix statistical modelling are used to investigate two main questions:  (1) what are the ecological factors that promote family living? and  (2) does the presence of potential helpers influence lifetime reproductive success and overall fitness of breeders and the helpers themselves?   I predict that families will be more common where and when ecological conditions render dispersal and independent breeding costly and helping beneficial. Finally, I will model what costs of dispersal and benefits of helping are necessary to promote family living in humans. It is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The search for new physics through precision measurements of the CKM angle gamma' (ONEDEGGAM).

assistant: **Innovation**

There is a strong conviction that the Standard Model of particle physics is only a low energy approximation to a higher energy theory containing new fundamental particles. For example, it is not possible to explain the large asymmetry between the properties of matter and anti-matter that must exist to create the universe within we live, with the Standard Model that can only accommodate asymmetries orders of magnitude smaller. The theoretical framework that describes these asymmetries is the Cabibbo-Maskawa-Kobayashi (CKM) matrix.  Through study the of the differences between the decay of certain types of hadrons containing a beauty quark, and the corresponding anti-particle decays, this project will lead to a precision measurement of a phase commonly called “gamma” which is related to some of the elements of the CKM matrix.  The beauty hadron decay chain involves subsequent decay of charm hadrons, which are not well understood. By understanding this part of the process, in a larger range of decay modes and with significantly enhanced sensitivity than previously possible, the overall understanding of the beauty hadron decay chain is improved. Using the distinctive data collected by the BESIII in China, it is possible to make a number of new measurements that relate to the decay of charm hadrons. With this knowledge it becomes possible to gain considerably more sensitivity from the copious amounts of beauty hadron decays that will be collected by the LHCb experiment at CERN and the Belle II experiment in Japan over the timescale of this project. This new strategy to exploit the synergy between the different experiments means that a global precision of 1° is within reach. This precision has excellent potential to uncover significant discrepancies within the CKM matrix that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'International comparisons of product supply chains in the agro-food sectors: determinants of their competitiveness and performance on EU and international markets' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project will deliver a coherent and innovative evaluation of competitiveness of European food chains by integrating various new approaches. Based on this, the research results allows to deduce a congruent, coherent and consistent set of policy recommendations aiming at improving competitiveness and promoting the Knowledge Based Bio-Economy in Europe.The analysis is conducted along two lines, (1) conception and indicators of competitiveness and (2) its determinants. In the first part a comprehensive definition of competitiveness will be developed by integrating the finding from selected theoretical micro and macro approaches. In this respect the conventional conception will be extended by moving from the industry to the value chain perspective and considering commodities as well as intermediary and final products. This framework constitutes the basis for the empirical analysis, where the EU position on world markets will be discussed in relation to that of major competitors.The second part deals with selected determinants of competitiveness. These include policy intervention and business environment, productivity in agriculture and food processing, the functioning of domestic and international markets, the choice of governance structures as well as innovative activities in food processing. The investigation of each determinant will be innovative and extends the state of the art by deepening the theoretical backgrounds, extending the methodological approaches or applying empirical methods for the first time. The analysis of the determinants will contribute significantly to be better and deeper understanding of competitiveness and the deduction of policy recommendations.Research will be conducted by a team that was constituted according to the needs of the research pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bacteriophages as vehicles for antimicrobial resistance determinants: Do they represent an environmental risk?' under Horizon Europe.

assistant: **Concept**

Although antibiotic resistance is a major and growing public health concern, surveillance for the expansion of this phenomenon in environmental settings has not been fully explored. However, recent studies suggest that antibiotic resistance found in clinical settings may emerge from environmental sources. In fact, the environment is continually exposed to a wide variety of antimicrobials and their metabolites through wastewater treatment plant discharges, agricultural runoff, and animal feeding operations, which may contribute to the emergence and spread of antibiotic resistance. It is therefore necessary to understand the mechanisms and factors that promote antibiotic resistance. The PHASTER project aims at exploring the presence, diversity, and abundance of bacteriophages in the environment. Particular points of interest will be the study of bacteriophages that lead to the mobilization of antibiotic resistance genes (ARGs) and their interaction with antibiotic compounds, even at extremely low concentrations, similar to those found in some aquatic environments. Mesocosm experiments will also be conducted to examine how bacterial communities respond to the presence of bacteriophages harbouring ARGs under stressful conditions, such as exposure to antibiotics. In order to reach these goals, a combination of metagenomics and bioinformatics approaches will be used to investigate the sources of ARGs, their environmental distribution and how anthropogenic inputs affect their spread. A better understanding of the mechanisms and factors that contribute to antibiotic resistance will permit the implementation of appropriate public health strategies, policies, and mitigation programs. Special attention will also be devoted to dissemination so that stakeholders and policy makers ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Clearing house mechanism on desertification for the northern mediterranean region' (CLEMDES).

assistant: **Innovation**

The countries of the Northern Mediterranean, region are affected by desertification and for this reason they have prepared national and regionalaction programmes. One of the priorities identified in these programmes is the diffusion of information among the public. The present project aims to set up an Internet based network devoted to the improvement of the diffusion of information. The establishment of an Internet based tool will decentralize existing information using the national language. The project aims to identify a common format and terms of reference for the setup of a Mediterranean portal and of national Internet based information facilities. Two workshops are planned for the identification of priorities and the presentation of results at international level. At national level meetings will be organized to involve the various stake holders and collect information and data to be diffused through Internet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'EU-based Production and Exploitation of Alternative Rubber and Latex Sources' under Seventh Framework.

assistant: **Concept**

Natural rubber is a widely used raw material essential to industry, medicine, transportation and defence, whose major source, the rubber tree Hevea brasiliensis, is currently both sustainable and environmentally beneficial. However, increased worldwide demand for natural rubber and latex means that alternative sustainable sources are urgently required. In order to meet this challenge, we propose to create a Network that links all stakeholders involved in the development and sustainable use of Parthenium argentatum (guayule) and Taraxacum koksaghyz (Russian dandelion) as alternative rubber and latex sources in the EU. To guarantee the sustainable development and exploitation of both crops throughout the value creation chain, the project includes research into the collection and creation of new germplasm, biochemistry and genetics, breeding, agronomy, processing, and product development. The entire rubber biosynthetic pathway will be analysed, and potential bottlenecks will be identified and bypassed through targeted conventional breeding. Genes involved in rubber biosynthesis will be mapped, helping to accelerate breeding strategies in order to generate plants with commercially-viable rubber yields. Such plants will be tested for efficient growth and rubber production in the field under different climatic and edaphic conditions in Europe. The technical performance and economic potential of rubber extracted from these plants will be evaluated by producing specific prototypes, such as surgical gloves and tires. The envisaged consortium will create a collaborative network of European research organisations and industrial participants, with the necessary scientific and administrative expertise and cross-disciplinary experience to meet the project objectives, and the motivati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Galileo Ready Advanced Mass MArket Receiver' (GRAMMAR) targeting Seventh Framework.

assistant: **Abstract**

Building on the success of FP6 projects, in particular the GREAT project, GRAMMAR seeks to address the mass market receiver by extending the current state-of-the-art technologies for the mass market segment.Specifically, we are addressing the following gaps identified as obstacles for producing high-quality mass market receivers:• No economic solutions for accurate dual-frequency RF and baseband hardware• No existing GPS/GALILEO receiver solutions• Poor robustness and location availability in indoor and urban environmentsThe goals of GRAMMAR’s technical work are:• The development of a hardware prototype for a mass market receiver using a single chip dual frequency receiver and an FPGA based baseband allowing for rapid prototyping of advanced algorithms and techniques.• The identification, evaluation and simulation of enhanced algorithm concepts for next generation mass market receivers.We aim to produce functional prototypes of the receiver and its components, enabling practical testing and demonstration at the completion of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Nature of Degrees of Belief' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The ER (Edward Elliott) is an early career researcher. The focus of his research to this point has been the philosophy of mind (particularly issues relating to mental representation) and the mathematical foundations of decision theory. The research goal of the project is to develop a novel account of the nature of degrees of belief (explained below), which is capable of accommodating what we have learnt empirically about ordinary agents’ probabilistic reasoning and decision-making processes in recent decades. This project builds on the ER’s existing research expertise, but with the support of the host institution (University of Leeds) and the supervisor (Professor Robert Williams), the scope of his work will be extended into new areas. Engagement in these areas will progress the ER’s career and forge connections to the European philosophical community. By drawing together issues from the philosophy of mind and formal epistemology/decision theory with an eye to the empirical work relevant to these areas, this project will help to establish the ER’s position at the cutting edge of contemporary discussion.The research goal of the project is to develop a novel account of the nature and representational content of the degrees of belief of ordinary, non-ideal human beings. Specifically, the project will draw on recent work on the formal foundations of decision theory, as well as recent empirical evidence regarding decision-making and probabilistic reasoning, for the development and defense of a broadly functionalist account of degrees of belief. The account will centrally involve a novel perspective on the nature of degrees of belief and the relationships that hold between different kinds of degrees of belief. A centerpiece of the account will be a new decision-theoretic repr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Selectively Targeting Oscillations in Parkinson's disease: Causal effects of the beta-rhythm on motor control' (STOP-Beta).

assistant: **Concept**

Parkinson’s disease is a frequent and disabling neurological disorder, which heavily impairs patients’ ability to perform and control movements. Electrical stimulation of a deep-seated brain region, the subthalamic nucleus (STN), has been shown to significantly improve patients’ motor function and quality of life. Recent technological advances in deep brain stimulation (DBS) render it possible to adjust electrical stimulation of the STN to ongoing brain activity, referred to as closed-loop DBS. Here, the implanted electrodes do not only send signals to the brain but also read out neural signals generated by the brain. Closed-loop DBS offers the intriguing possibility to specifically suppress pathological brain activity while leaving physiological activity unaltered. We propose an innovative and ambitious project, which the researcher will conduct in the Experimental Neurology group headed by Prof. Peter Brown at the University of Oxford, a world-leading laboratory in closed-loop stimulation. In this project we aim to test the hypothesis that closed-loop DBS that selectively targets pathological synchronous firing of neurons at 13 – 30 Hz, the so-called beta-rhythm, will interrupt neural activity related to motor impairment, but not normal functions of the brain. To this end, Parkinson patients with implanted electrodes in the STN will perform two tasks probing different aspects of motor control whilst receiving closed loop stimulation. We will simultaneously record activity from the STN and areas localized on the surface of the brain. This will allow us to assess how suppression of the beta-rhythm affects motor-related activity and connectivity in the human brain revealing it’s causal effects on motor function. Selective suppression of abnormal brain function and preser