RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-resolution microscopy without lenses: a new generation of imaging technology' (Lensless).

assistant: **Concept**

Lensless imaging is an elegant approach to microscopy, in which a sharp image of an object is retrieved by numerical means rather than by actual optical components such as lenses. Such an approach allows high-resolution imaging using only a light source and an image sensor. Multi-wavelength phase retrieval (Witte et al., patent application PCT/NL2013/050618) provides a general framework for lensless imaging, which allows the development of surprisingly simple yet high-resolution imaging devices. By detecting wavelength-dependent differences in wave propagation, I have recently shown that amplitude and phase of an object field can be reconstructed with high contrast and resolution. This approach works for complex objects in both reflection and transmission. As such, lensless microscopes have advantages in size, cost, robustness and simplicity, and provide a powerful alternative to conventional imaging systems in many applications.My aim with this proposal is to advance this new technology towards high-impact applications, and to forge a coordinated research program on lensless imaging technology and its applications. I will develop lensless microscopes to image many cell cultures in parallel, as well as smartphone-based lensless microscopes for low-cost point-of-care diagnostics in third-world countries. Lensless microscopy through optical fibers will be implemented as a novel tool for minimally invasive endoscopic imaging. Since the technology does not require precision optical components, I will be able to extend it to shorter wavelengths. Applications in EUV metrology and soft-X-ray imaging become feasible, such as ultra-high-resolution surface profiling of lithographic wafers.This program provides exciting new prospects for fundamental science, industrial metrology a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Union Contest for Young Scientists 2011' under Seventh Framework.

assistant: **Concept**

The European Union (EU) Contest for Young Scientists, an initiative of the European Commission, was set up in 1989 to promote the ideals of cooperation and interchange between young scientists. The Contest is the annual showcase of the best of European student scientific achievement and as such attracts widespread media interest. The 23rd  EU Contest for Young Scientists will take place 23- 28 September 2011 in Helsinki, Finland. Host organiser is the the Finnish Association of Graduate Engineers TEK (TEK).""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Controlled Growth of Lightweight Metal-Free Materials for Photoelectrochemical Cells' to be submitted under Horizon 2020.

assistant: **Abstract**

One of the most promising future sources of alternative energy involves photoelectrochemical cells (PECs) that can convert sunlight and water directly to clean hydrogen fuel. Up to now, the PEC field has been dominated mostly by metal-based materials and despite the progress in this field, semiconductors that fulfil all the stringent requirements as PEC semiconductors do not exist today and novel materials are still much sought after. Thus, the development of suitable semiconductor materials will be a game changer, allowing PECs to fulfil their role in the energy-devices landscape. The aim of this project is to introduce a new class of metal-free materials that are particularly suitable as semiconductors in PECs through the development of new strategies for the controlled synthesis and growth of metal-free materials on various substrates, ranging from carbon nitride to nitrogen-doped carbon and new carbon-nitrogen-phosphorus/boron/sulfur materials (referred as CNXs, X = P, B or S). Central to this goal is the understanding of the growth mechanism of CNX layers from the molecular level, which will in turn permit the rational design of synthesis and deposition methods. More specifically, we will (i) develop effective deposition pathways of CNXs on substrates with controlled properties, (ii) understand the factors that determine the CNX layer properties and, from this, (iii) control CNXs properties such as band gap, exciton lifetime, crystallinity, porosity, and electronic structure, with the aim of improving their photoelectrochemical activity through rational design of the synthetic parameters. This highly interdisciplinary proposal combines materials science, photoelectrochemistry and supramolecular chemistry. It will open up new opportunities in these fields, in partic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Researchers’ Night 2013 in the Czech Republic' to be submitted under Seventh Framework.

assistant: **Abstract**

Researchers´ Night 2013 Czech Republic is based on the performance of scientists as ordinary people who are in essence no different from the general public. The goal is to bring together the public at large and researchers to improve the image of researchers and to strengthen the public recognition in the scientific work in a funny way. The next goal is to stimulate young people's interest in scientific careers through this event. This year's motto for RN2013CZ is ""Energy to knowledge."" Energy will become the common element across the venues of the Researchers´ Night in the Czech Republic. The theme of ""Energy to knowledge"" will demonstrate not only the importance of science and scientists who convey us energy in those various forms but also their efforts needed to be done in scientific research. As one of the ideas that will fulfil the theme ""Energy to knowledge"" is accompanied by its savings or perhaps thinking of energy as an important element in our lives with whom we should be treated objectively, when taking into account the aspects of responsible research and innovation. The goal is to make each venue focused on the presentation of energy, according to the direction of each participants´ research and activities. Visitors of RN2013CZ will have the opportunity to explore the scientific work, have fun and share their leisure time with the scientists. Anyone regardless of age and scientific skills will be able to participate in experiments, watch demonstrations, take part in competitions or just enjoy having fun with researchers. The role of the European Commission in supporting this particular event will be described and the EC will be presented as an institution that continuously and largely supports research Europe-wide.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Theranostic Immune Cell' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Recent studies on the developments of immune mobilizing monoclonal T-cell receptors against cancer (ImmTAC), bispecific T-cell receptors (TCR) engagers, and chimeric antigen receptor (CAR) cell-based therapies, have highlighted their potential to treat Multiple Myeloma (MM). These treatments, however, are expensive. The manufacturing processes that are employed for their generation are lengthy, and their commercial scale production is reliant on a multitude of equipment and operators that cannot easily be incorporated in the footprint of most local hospitals. Moreover, patient responses to these treatments remain heterogenous. We propose an innovative multidisciplinary approach that aims to develop a novel theranostic immune-cell based compound. This approach is based on the functionalization of the immune cells with theranostic ultrasmall macromolecules (USM); USM having a diameter size below 10 nm to allow renal clearance and minimize toxicity. The clinically-relevant imaging properties of the USM will allow to unveil various challenges remaining in the field of immunotherapy, such as to better elucidate the priming sites of immune cells, to track their migration in the body, as well as to localize their niche upon the establishment of minimal residual disease. By labelling the immune cells ex vivo, the diagnostic imaging properties enabled by the presence of the USM on the immune cell surface will allow to generate better ex vivo immune cells therapeutics (such as simili-CAR NK cells) with a rationalized target selection, will improve the cell dosing, and will help to better stratify the patient population in order to offer an improved personalized treatment plan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bacteria-phage-antibiotic interactions in variable environments: a community ecology perspective' (COEXIST) targeting Horizon 2020.

assistant: **Abstract**

There is increasing awareness that diversity in microbial communities likely plays a critical role in multiple biological processes, from regulating human health to sustaining ecosystem services. Along with advances in molecular technologies, this realisation has seen a rapid growth in efforts to catalogue microbial life, and yet we still have a surprisingly poor understanding of the mechanisms maintaining microbial diversity. With up to 1,000 different species in the human gut alone, classical ecological explanations for diversity maintenance appear unlikely to hold. A resolution to this coexistence paradox may lie in the dynamic nature of microbial environments. The goal of this project is to investigate whether recent theoretical advances in understanding coexistence in non-equilibrium systems can provide insights into microbial diversity in the presence of viral parasites and antimicrobial agents that naturally vary in concentration in space and time. To this end, I will conduct a series of innovative experiments on multi-strain communities of pathogenic and non-pathogenic Escherichia coli under spatial and temporal variability in nutrient resources, phages and antibiotics. The project is unique in community ecology in leveraging high-throughput methods in a model microbial system of significant human interest; and in its focus on the interaction between non-linear growth functions and environmental variability as a critical determinant of community dynamics. The results will i) enhance our understanding of the role of viral parasitism in regulating diversity; ii) provide insight into emerging theory on the operation of coexistence mechanisms at different spatial and temporal scales; and iii) inform evolutionary and epidemiological research into the combined effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The macroevolutionay patterns of Mesozoic mammals' in the context of a Horizon Europe call.

assistant: **Objectives**

Since their origination in the Late Triassic, a series of evolutionary innovations throughout the Mesozoic Era resulted in the morphological, physiological, and ecological bauplan for mammals and set the path to their modern success. Due to the incomplete nature and limited access to 3D data for Mesozoic mammal specimens, their evolutionary morphology remains unexplored under a quantitative framework, creating a major knowledge gap in vertebrate evolution. This proposal aims to investigate macroevolutionary patterns of early mammals during the Mesozoic using advanced 3D geometric morphometric techniques. It will generate a new dataset covering 30 well-preserved crania and over 180 upper and lower dentition across major clades of Mesozoic mammals, using advanced 3D scanning technologies, including X-ray Computed Tomography, Synchrotron and Neutron Tomography. Cutting-edge landmark-based and landmark-free morphometric methods will be used to quantify shape variation and underlying effects of allometry and ecological traits. These analyses will reveal trends of cranial evolution, testing whether the cranial morphology in Mesozoic mammals evolved gradually or followed a punctuated pattern. It will also reveal shifts of phenotypic integration and modularity across the tooth row, providing insights into the mechanisms that shaped unusual key innovations of heterodonty and dental complexity in mammals and how that related to other changes in skull morphology through the Mesozoic. The proposed research will not only fill a significant knowledge gap in vertebrate evolution but will also equip the applicant with essential skills in quantitative approaches urgently needed in Chinese paleontology, positioning the applicant as a leading independent researcher in this field.


**Keyw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Local training network: Netherlands Earth System Science Centre: “NESSC”' (NESSC).

assistant: **Innovation**

Forecasting the magnitude of future global warming is among the great scientific challenges. Model estimates of long-term warming resulting from a doubling of the CO2 concentration relative to the pre-industrial era range between 1.5 and 4.5 °C. This large uncertainty may represent the difference between the melting or conservation of large continental ice sheets, and between habitable and inhabitable regions.NESSC, the Netherlands Earth System Science Center, addresses climate-related research questions, dealing with past, present and future interactions between the geosphere, biosphere, hydrosphere, cryosphere and atmosphere. Specifically, NESSC studies the response of the Earth System to perturbations and will merge information obtained from past climate, using climate proxies, with data and models for the modern climate. NESSC brings together renowned experts in the fields of palaeoclimate proxies, climate reconstructions, biogeochemistry, microbiology, and theory and modelling of climate. These experts join forces to obtain novel insights in climate research. All scientists involved have ample experience with supervising PhD students and leading successful research groups.Through COFUND NESSC will expand its research and training programme internationally, with an additional 13 Early Stage Researchers. NESSC will significantly advance our understanding of the Earth System functioning in the future. The COFUND programme is tightly connected with multiple national and international partner organisations, each providing complementary research and/or training. Through COFUND NESSC will maintain and further expand its excellent worldwide position.


**Keywords:** Climate research, tipping points, doctoral training, multidisciplinary programme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A test for predicting the efficacy of common platinum drugs enabling personalized chemotherapy for bladder cancer patients.' (2014-2020).

assistant: **Innovation**

Platinum-based chemotherapy is the primary therapeutic intervention for over 500,000 patients per year in the EU.  Although some patients are cured by this type of chemotherapy, as many as 75% of lung cancer patients and 60% of bladder cancer patients show no benefit and could be more appropriately given alternative treatments, and therefore over €4bn annually is wasted on unnecessary treatments. There is a need for a rapid, accurate test to distinguish those patients who are likely to respond to chemotherapy and those who are not. Accelerated Medical Diagnostics aim to personalise chemotherapy for cancer patients through their own developed PlatinDx assay, which can be used to identify those patients which are appropriate for platinum-based chemotherapy. Cancer patients are given a microdose (1% of the therapeutic dose) of a platinum-based drug, followed by quantitation of drug-DNA adducts in biopsy tissye using accelerator mass spectrometry (AMS). Levels of drug-DNA damage are measured by AMS in white blood cells and tumor biopsy tissue, which are used as a predictor of therapeutic response. Within the innovation project Accelerated Medical Diagnoistics intend to: gain medical certification within the EU; run a scaled up clinical trial to gain significant results; and adress the EU market and launch their service in the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '4th mp euro-med summer school' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The proposal is for a Summer School of 10 days' duration (8 full working days), entitled: Migration in the Euro-Mediterranean Area: Demographic, Economic, Legal, Political and Social Dimensions. International migration is a key dimension of the construction of a peaceful and prosperous Euro-Mediterranean area. What motivates migration - the search for more material welfare, political freedom, or physical security signals particular features of the sending countries, such as pressures exerted by mal-development or rising insecurity, or strategies for integrating into the world economy through labour mobility and networking. It also signals the existence of differentials between sending and receiving countries, in terms of economic conditions or political situation. Finally, it signals the availability of routes from departure to arrival countries, whether through legal procedures or illegal channels. Migration is major factor of change. In sending countries, emigration can promote a wide range of transformations, from the various economic impacts of expatriate workers' remittances, to the emergence of new middle classes, the reinvention of identities and the diffusion of alternative models and behaviours, including political ideals and the various ways through which diasporas can influence politics in home countries.In receiving countries, immigration can also prompt changes in areas such as demographic growth, the balance of the labour market and employment, social welfare, security, integration of ethnic diasporas and religious communities. It may also lead to the adaptation of legal provisions or to new political debates. Lastly, international migration is a component of international relations. Regulating movements across borders, containing trafficking, redefining c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An innovative topical drug delivery system for improving chronic wound healing' under Horizon 2020.

assistant: **Concept**

Skin is the largest organ in the human body, forming a protective physical barrier against the outside world. Damages to skin due to physical, chemical and biological factors lead to wounds. While minor wounds heal on their own, chronic wounds (wounds that do not heal within 8 weeks), such as diabetic foot ulcers, subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of resources. Wound healing is a complex, highly regulated process, and complications affect the quality of life of >4 million a year in EU (more than cancer & diabetes) that struggle to live with hard-to-heal injuries, as it can lead to infection, tissue and bone necrosis, pain and in some severe cases even amputation. Stratpharma has developed a range of primary dressings formulated as a silicone-based gel, which can be used on any wounded, damaged, compromised or diseased skin surface. This proprietary film-forming gel is also shown to be an excellent drug delivery system, using which active compounds can be delivered to the wound, thereby enhancing clinical outcomes. Using this property, Stratpharma aims to develop a breakthrough formulation, containing gel and bioglass technology, for improved chronic wound healing. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall innovation project, Stratpharma will further test and validate the new formulation, begin clinical trials, implement IP strategy and perform scaling-up activities.