RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Key Interventions for Sustainable Employment in the Information Society for Disadvantaged Groups'.

assistant: **Innovation**

The study will analyse solutions for the socio-economic dimensions of the transition to sustainable employment in the information society for disadvantaged groups. The research will develop a framework of interventions, building on lessons from the EU EMPLOYMENT Initiative projects with sustainable IS employment and mainstreaming outcomes. The research will study indicators of success in interventions in four EU countries. Research will include interviews with former EMPLOYMENT participants currently in sustainable employment, and with employers, and case studies of mainstreaming initiatives. The project will develop guidelines and models of best practice for interventions addressing socio-economic aspects of sustainable IS employment. It will also identify and analyse ways to strengthen future EU policy and IST Programme research on an inclusive information society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Euroconference / 2^nd International Meeting Cellular Responses to Oxidative and Osmotic Stress: Sensing, Signalling and Gene Expression""' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The main scientific objective of the meeting is to set up a forum that will enable the exchange of information between scientists studying oxidative and osmotic stress in different organisms. Indeed, few meetings bringing together people working on the molecular mechanisms underlying the stress response using different cell models are occurring at present, namely in Europe. This meeting will address the sensing of both stress challenges (osmotic and oxidative) as this issue remains an intriguing event. The signalling pathways have been disclosed, however the regulation associated with the stress response and the cross talk between the pathways still remains to be clarified. The cell adaptation to the changes in environmental conditions including change in the expression of specific genes and in enzymes activities will also be analysed. In this context the induction of similar genes and the activation of identical enzymes by the two stress agents indicates common defence mechanisms. However, the relevance of the common responses in different cell systems is still a matter of discussion and new approaches will be discussed, namely its importance in diseases and in biotechnology (e.g. plant development, bioreactors). An integrative approach of the stress responses will be discussed in deep.he topics will be presented by selected 8 keynote speakers, covering: a) oxidative stress response in bacteria, in yeast, in plants and in mammals; b): osmotic stress in bacteria, in yeast, in plants and in mammals (see speakers name in the meeting programme). There will be two lectures, one covering an overview of common mechanisms of the stress response (D.Thiele, USA) and the role of kinases in different cell systems (S.Keyse, UK). In addition, 24 short talks (15 min) will be selected
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Statistical Inference from Multiscale Biological Data: theory, algorithms, applications' (SIMBAD).

assistant: **Innovation**

The last two decades have witnessed giant experimental breakthroughs in different areas of the life sciences, from genomics to epidemiology. Thanks to modern high-throughput techniques, biological systems across multiple scales from single molecules up to entire populations can now be probed quantitatively at high spatial and temporal resolutions. Besides enhancing our basic knowledge of a systems constituents, these data potentially encode a plethora of information about the functional constraints that govern its evolution and the physical constraints that limit its performance, as well as about levels of organization, dynamical constraints or design principles that would be hard to identify from low-throughput data. Extracting this information is also crucial for applications ranging from the design of proteins with a desired functionality to the reconstruction of contacts during an epidemics. Inverse statistical mechanics attempts to do it by inferring generative models (Boltzmann distributions) from data using methods from the physics of disordered and random systems. Specific characteristics of biological data however, like strong undersampling and heterogeneity, limit the effectiveness of these tools. SIMBAD aims at developing a class of statistical inference techniques capable of overcoming these issues. In SIMBAD, theoretical work will supply concepts and methods to address four pressing problems (learning protein sequence landscapes, inverse modeling metabolic networks, inferring contact networks from epidemiological data, and improving survival analysis models), which in turn will guide the theory towards integration with the existing standards of each field. This effort promises to open new pathways for basic research to impact economic, technological and soc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Single unusual DNA' under Seventh Framework.

assistant: **Concept**

Certain nucleic acids sequences can form unusual structures, like triplexes, G-quadruplexes and i-motif. Nowadays, several genetic diseases have proved to be mediated by the formation of non-B DNA structures at certain chromosomal locations. Therefore, it is very important to inversigate these unusual DNA structures, which may well be biologically relevant, at the molecular level. To study the function of such unusual DNA structures in vivo, it is important to understand how they assemble and interact with ligands. Until now, most of the these studies are carried out in dilute solutions, which do not reflect the real conditions in vivo because the physiological milieu is crowded with various biomolecules. Moreover, current research methods related to unusual DNA structures are ensemble methods, a lot of important phenomena may inherent in ensemble measurements due to population averaging.Magnetic tweezers are extraordinarily sensitive, as this technique is capable of applying piconewton-scale forces, allowing it to provide direct data on the molecular-scale workings of biological systems. Therefore, the magnetic tweezers technique is well suited to experiments on single DNA molecules.The proposal we submitted is the first attempt to investigate unusual DNA structures by magnetic tweezers. We aim to understand how they behave under near-physiological conditions and how the interaction with ligands may affect their behavior. The results can promote other researchers to learn the formation pathways of these unusual DNA structures, and help them to effectively design anticancer drugs or to understand how these structures may interfere with key biological processes. To our knowledge, such study of unusual structures has never been performed – or at least published – with thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Crosstalk between microbiota metabolites and immune cells, the missing link to brain damage.' (MetaBiota).

assistant: **Concept**

Stroke is the second most common cause of death in Europe: accounting for almost 1.1 million deaths each year, with only 15% of stroke patients being eligible for a specific treatment. I have reported–in this year Nature Medicine’s April issue–that microbiota influences the severity of stroke injury through an impaired intestinal immune function. These findings revealed for the first time the critical implication of the microbiota as a novel and relevant prospective target for therapeutic strategies in stroke. However, the development of efficient therapies requires to identify which bacterial species and bacterial products are involved in the modulation of the immune response and thereby influence stroke outcome. To fill in this knowledge gap, my proposal aims to identify how metabolites derived from gut bacteria modulate the intestinal immune response and thereby influence the brain in the setting of stroke. To investigate this novel paradigm, I will use cutting-edge metabolomic tools to precisely analyze a large panel of metabolites, high-throughput sequencing to identify bacterial species, specific knock-out mice and mouse models of altered-microbiota available at the host institution and its established collaboration partners. This is the first attempt to discover a relationship between microbial metabolites, immune cell regulation and severity of ischemic stroke. Information derived from this project will have the potential to enable development of a “neuroprotective” microbiota–by diet intervention–and reduce the dramatic consequences of stroke. The Marie Sklodowska-Curie individual fellowship (MSC IF) will allow me to obtain the required methodological knowledge, access to critical infrastructure and collaboration partners in order to achieve this interdisciplin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Latin America and Europe Liaison' (LAEL) targeting Seventh Framework.

assistant: **Abstract**

Europe and Latin America have a very similar cultural background and share a common historical heritage. The present proposal aims at strengthening scientific collaborations and research partnerships between research institutions in Europe and in Latin America, in key emerging fields of contemporary science and in particular in • Neuroscience • Biophysics and Molecular Neurobiology • Bionanotechnology and Genomics The proposal gathers well-known Institutes in Latin America and Europe with distinct but complementary scientific interests and experience. This project, therefore, covers broad areas in the above disciplines and is designed to: • provide a forum for the exchange of staff and young students and researchers among these institutions • foster scientific collaborations among more senior scientists • provide opportunities to pursue specific projects in these key emerging area fields Proposed scientific exchanges and collaborations are expected to develop more open-minded scientists, able to carry out at the same time original and competitive studies and to participate with success in the development of research and high standard training in underdeveloped areas. Taken as a whole, institutions participating in the present proposal offer a panel of understanding, know-how, specific experience, technology and interactions with external entities - many of which of biotechnological nature - that is not common in Europe and Latin America. The proposal, therefore, covers broad areas in the above disciplines and is designed to give young researchers and students in the early stages of their carrier, common general and advanced background training, as well as opportunities to pursue specific projects in areas they intend to specialize in during their subsequent professional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'COoperative Real-Time EXperiences with EXtended reality'.

assistant: **Objectives**

The mission of CORTEX² is to bridge the divide between widespread video-conferencing tools and state-of-the art XR-based solutions, democratising the uptake of next-generation eXtended Reality tele-cooperation among a large number of industrial segments and SMEs. To this aim, our project will provide: (1) Full support for AR experience as extension of videoconferencing systems when using heterogeneous services end devices through a novel Mediation Gateway platform (2) Resource-efficient teleconferencing tools through innovative transmission methods and automatic summarization of shared long documents (3) User-friendly and powerful XR experiences with instant 3D reconstruction of environments and objects and simplified use of natural gestures in collaborative meetings (4) Fusion of vision and audio for multi-channel semantic interpretation and enhanced tools such as dialoguing virtual conversational agents and automatic meeting summarization (5) Full integration of IoT devices in XR experiences to optimize interaction with running systems and processes (6) Optimal extension possibilities and wide uptake opportunity through the delivery of the core system with open APIs and the the organisation of Open calls for extensions towards more technical modules and more use cases in various segments. In order to ensure large adoption and fast scaling of our extended remote cooperation solution, we will use the widespread teleconferencing solution Rainbow from Alcatel Lucent Enterprise as a backbone for our innovative extended reality based tele-cooperation concept, which counts today more than 3 million users worldwide. CORTEX will extend Rainbow to allow for fully interactive XR-based cooperation and will be demonstrated in three pilots: industrial production, business meetings
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Primary Cilium-Mediated Mesenchymal Stem Cell Mechanobiology in Bone' (CiliaMechanoBio).

assistant: **Concept**

Every 30 seconds a person suffers an osteoporosis-related bone fracture in the EU, resulting in significant morbidity, mortality, and health-care costs estimated at €36billion annually. Current therapeutics target bone resorbing osteoclasts, but these are associated with severe side effects. Osteoporosis arises when mesenchymal stem cells (MSC) fail to produce sufficient numbers of bone forming osteoblasts. A key regulator of MSC behaviour is physical loading, yet the mechanisms by which MSCs sense and respond to changes in their mechanical environment are virtually unknown. Primary cilia are nearly ubiquitous ‘antennae-like’ cellular organelles that have very recently emerged as extracellular mechano/chemo-sensors and thus, are strong candidates to play a role in regulating MSC responses in bone. Therefore, the objective of this research program is to determine the role of the primary cilium and associated molecular components in the osteogenic differentiation and recruitment of human MSCs in loading-induced bone adaptation. This will be achieved through ground-breaking in vitro and in vivo techniques developed by the applicant. The knowledge generated in this proposal will represent a profound advance in our understanding of stem cell mechanobiology. In particular, the identification of the cilium and associated molecules as central to stem cell behaviour will lead to the direct manipulation of MSCs via novel cilia-targeted therapeutics that mimic the regenerative influence of loading at a molecular level. These novel therapeutics would therefore target bone formation, providing an alternative path to treatment, resulting in an improved supply of bone forming cells, preventing osteoporosis. Furthermore, these novel therapeutics will be incorporated into biomaterials,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effects of Prenatal Exposure to Acrylamide on Health: Prospective Biomarker-Based Studies' under Horizon 2020.

assistant: **Concept**

Background: Acrylamide is a chemical formed in many commonly consumed foods and beverages. It is neurotoxic, crosses the placenta and has been associated with restriction of fetal growth in humans. In animals, acrylamide causes heritable mutations, tumors, developmental toxicity, reduced fertility and impaired growth. Therefore, the discovery of acrylamide in food in 2002 raised concern about human health effects worldwide. Still, epidemiological studies are limited and effects on health of prenatal exposure have never been evaluated. Research gaps: Epidemiological studies have mostly addressed exposure during adulthood, focused on cancer risk in adults, and relied on questionnaires entailing a high degree of exposure misclassification. Biomarker studies on prenatal exposure to acrylamide from diet are critically needed to improve exposure assessment and to determine whether acrylamide leads to major diseases later in life.  Own results: I have first authored a prospective European study showing that prenatal exposure to acrylamide, estimated by measuring hemoglobin adducts in cord blood, was associated with fetal growth restriction, for the first time. Objectives: To determine the effects of prenatal exposure to acrylamide alone and in combination with other potentially toxic adduct-forming exposures on the health of children and young adults.Methods: Both well-established and innovative biomarker methods will be used for characterization of prenatal exposure to acrylamide and related toxicants in blood from pregnant women and their offspring in prospective cohort studies with long-term follow-up. Risk of neurological disorders, impaired cognition, disturbed reproductive function and metabolic outcomes such as obesity and diabetes will be evaluated.Perspectives: CHIPS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrated and automated manufacturing process for furniture industry' in the context of a Fifth Framework call.

assistant: **Objectives**

The aim of the present project is that of creating a unified, cost-reducing, low-maintenance, flexible and user-friendly production system for furniture manufacturing, using the most advanced technologies available, in particular: integrated intelligence, software- supported control platforms, real-time programming and linear motors. The result of the project will be an integrated and automated production process for furniture manufacturing, replacing the expensive hardware solutions and manual assembling applied nowadays. In particular, the innovations brought by the projecting the manufacturing process will be:1. An integrated managing system, based on common Windows NT environment,2. The real-time integration of design and production by means of ad-hoc conversion procedures between Auto- CAD designs and machine-data generation, 3. A wireless information transmission system between the computers and the actuating machines, 4. Linear motors and integrated intelligence for the boring and assembling processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Improved environmental evaluation techniques and tools for the promotion of effective cleaner technologies in the agricultural sector' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The agriculture has always been used as source of food and raw renewable resource, but because of its massive and capillary diffusion on the planet, causes serious effects on environment and ecosystem. This proposal aims at solving this problem, developing an environmental evaluation method based on LCA techniques (Life Cycle assessment, ISO 14040 series) useful for tomatoes and lettuce. The main objectives are:1) Development of the proposed method2) Creation of a database furan environmental evaluation of the standard cultivation techniques for tomato and lettuce3) Creation of a software to facilitate the calculation procedures4) Execution of a research on the state of art of the cleaner technologies in the cultivation sector for tomato and lettuce5) Selection of the most interesting technologies -using the new software- among the studies ones and selection of the most important LCA phases in which develop cleaner technologies6) Testing the most promising cleaner technologies in pilot cultivation using the new method) Economical and environmental estimation on the advantages obtainable extending at industrial scale the selected cleaner technologies