RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Palaeolimnological assessment of methane emissions from lakes in changing environment using stable isotopes' under Horizon 2020.

assistant: **Concept**

This proposal (PALAEO) aims to provide completely novel insights into the long-term dynamics of methane (CH4) concentrations and emissions from lakes in response to past climatic variation and anthropogenic impact. Lakes are an important component in the global carbon budget and their role as major sources of greenhouse gases, particularly CH4, has long been underestimated. This is partly due to the absence of long-term data sets of CH4 emissions from lakes, which makes predictions and modelling of lake ecosystem responses to future climate change extremely difficult. PALAEO will combine a unique experimental system, contemporary field observations and state-of-the-art palaeolimnology to develop, validate and apply methods to track long-term dynamics in CH4 in lakes. The different spatial and temporal scales are linked by a consistent methodology using stable isotope analysis applied to chitinous invertebrate remains, which have the potential to reflect past CH4 concentrations in the water. Sediment cores from the Arctic (Greenland), boreal (Finland) and temperate (Denmark) regions will be analysed. These cores also provide information on past environmental and ecological conditions, such as temperature, nutrient levels and community structure. Sampling from regions that have shown large climate variations (Arctic, boreal) and highly variable degree of human impact (boreal, temperate) will provide unique data for modelling how CH4 emissions from lakes will be affected under future warming scenarios. In addition, these data will allow the assessment of the relative importance of multiple pressures (climate warming, eutrophication) in driving the increases of CH4 emissions from lakes in different regions. This makes PALAEO a highly novel study linking change in the enviro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of calcium fluxes in mitochondrial dynamics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Mitochondria house hundreds of biochemical reactions involved in processes critical for the survival and homeostatic adaptation of the cell. Mitochondria are highly dynamic organelles, which adapt their shape and network depending on the cellular needs. As mitochondria play a central and unique role in metabolism, our understanding of the complex network of interrelations between mitochondria and other organelles has crucially changed our view on the cell biology of mitochondria and a new biology and pathophysiology of this organelle are emerging. Mitochondria are in dynamic contact with the endoplasmic reticulum (ER) and this specialized contact is essential for a number of relevant processes, including mitochondrial dynamics, lipid exchange, calcium homeostasis and apoptosis. The Mitochondrial Calcium Uniporter (MCU) and some of its regulators (MICU1-3, EMRE) have recently been identified as the key complex regulating mitochondrial calcium uptake with some already identified functions. The goal of this project is to define the complete interactome of the Mitochondrial Calcium Uptake Machinery (MCUM) in different physiological conditions and to characterize the functions associated to this complex. To address these goals, an unbiased proteomic analysis will be performed, both in cellulo (human cells) and in vivo (zebrafish), to identify the interactors of the MCUM at steady state and under different cellular stresses using the BioID technic. The mechanisms involving the MCUM in the regulation of mitochondrial dynamics, apoptosis and cell migration will be unravelled using molecular and cell biology experiments coupled with the most recent advances in microscopic analysis. Finally, we will explore the relevance of these findings in the physiopathology associated to mito
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Molecular neurobiology of a moonlight entrained circalunar clock'.

assistant: **Objectives**

Numerous scientific studies have established that the lunar cycle synchronizes reproductive behaviour and sexual maturation of animals as diverse as corals, polychaetes and fishes. Classical and recent work shows that in animals such as the annelid Platynereis dumerilii, dim nocturnal light serves as entrainment cue for an endogenous oscillator – a circalunar clock – that orchestrates reproductive and behavioral cycles. As circalunar clocks run with a (semi-)monthly period, they represent a fundamental biological phenomenon clearly distinct from the widely studied, solar light-entrained circadian (24h) clocks. Despite the vital importance of circalunar clocks, very little is known about the underlying molecular processes and responsible neuron types. This knowledge gap reflects the fact that until now, no suitable model system has been available to study circalunar clocks on the molecular and cellular level.This proposal takes full advantage of the recent establishment of substantial molecular resources and critical techniques for functional analyses in Platynereis, as well as our pioneering work on the first circalunar clock-regulated genes and the identification of four molecular candidates for the nocturnal light receptor.This now allows us to tackle two fundamental objectives:First, we aim to discover the molecular and cellular nature of the lunar light sensor(s) and their interplay with solar light photoreceptors.Second, we aim to characterize circalunar oscillatory genes and their associated neuron types thatwill pave the way to unravel the molecular and cellular nature of the circalunar oscillator.This work will provide new mechanistic insight into an unexplored biological mystery- circalunar clocks and their regulation by light. It also offers new conceptual adv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chirality inversion in colloidal self-assembly' (CINCOS).

assistant: **Innovation**

The chiral self-assembly of nanoscale building blocks offers a scalable route to functional materials, but understanding and controlling this process is a persistent challenge. A notable example is cellulose nanocrystals (CNCs), elongated nanoparticles extracted from natural cellulose that assemble into a  cholesteric liquid crystal phase in aqueous suspension. This helicoidal self-organisation can be preserved into the solid state to create structurally coloured films, offering a sustainable way to produce next-generation pigments and colourants. However, the CNC cholesteric phase is always found to be left-handed due to the presence of  ""bundles"", a sub-population of CNCs that act as colloidal chiral dopants and induce left-handed ordering. Inspired by the naturally-occuring CNC bundles, this project aims to produce cellulose polycrystals (CPCs), a new class of clustered nanoparticles produced by the aggregation of CNCs in the presence of a chiral ""glue"" provided by hemicelluloses. These CPCs will then be used as synthetic chiral dopants to induce a right-handed cholesteric phase in CNCs suspensions for the first time. This inversion of the handedness of CNC self-assembly will result in films that reflect RCP light in the visible range, enabling the creation of structurally-coloured materials with near-ideal optical performance. These findings will deepen our understanding of chiral colloidal self-assembly and open up new avenues of enquiry for research on bio-sourced nanomaterials.""


**Keywords:** colloidal self-assembly, nanocellulose, structural colour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Origin of Animals using high-quality Genomic Assemblies and Metagenomic Analyses' (OriGAMA) targeting Horizon Europe.

assistant: **Abstract**

One of the most fundamental questions in evolutionary biology is centred on our ancestors: How did animals originate? Recent advances in various disciplines have refined this question of whether the most profound divergence in the animal phylogenetic tree, estimated to have occurred approximately 800 million years ago, was between the sponges (Porifera) or the comb-jellies (Ctenophora), and this remains a contentious point of discussion within the scientific community. This is important as it influences our understanding of the evolution of the nervous, muscular and digestive systems. Did the ancestor of all animals already possess complex systems, or did these systems evolve at a later stage? The project described in this proposal aims to answer this question through multiple crucial steps, firstly by improving the genomic quality data from the animal clades in contention and their closest relatives, then by applying innovative and state-of-the-art phylogenomics, comparative genomics and molecular dating techniques, and thirdly through harnessing the power of hidden diversity in the environment through metagenomics. We will use our novel high-quality data to infer the animal tree of life, and importantly, to reconstruct the gene content and metabolism of their last common ancestor. Thanks to the use of complete sets of proteins, we will be able to address this question, for the first time, from a higher hierarchical level, rather than merely looking at the differences between gene histories. We can use our inference of these interacting metabolic networks, which are more conserved across deep time, to understand the evolution of the group and reconstruct the metabolism of the last common ancestor of animals.


**Keywords:** metagenomics, phylogenomics, animals, ctenoph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The International Register of Academic Job Categories. Facilitating Careers in the European Research Area' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Proof of Concept INTAC project will create a prototype of an online Register which systematically lists, explains and compares formal job categories and status positions of research- and teaching staff in 575 higher education institutions in France, Germany and Great Britain. It will set up the Register on a public multilingual platform and provide resources for career-relevant decision-making (such as career guidelines, CV templates, visualisation and mapping tools for career tracks and status systems, identifier of job equivalents, a community forum). While international academic mobility is growing at high rates and academic systems are rapidly changing, job-seekers as well as recruiting institutions often grapple with the fact that job and status categories in academic institutions (such as PRAG, Akademische Rätin or Teaching Fellow) are difficult to understand for those coming from other institutions or systems. As a consequence, academics may not recognize the most suitable career paths and academic institutions may not receive the best applications. Responding to a demand from academics, employers, unions, associations and organisations in the higher education sector, the INTAC Register aims to facilitate academic recruitments, make national and international academic job markets more transparent and help academic career planning in the European Research Area. In order to bring the Register to the market, INTAC will create a diversified revenue stream, including regular premium user fees and licensing to academic social media. Future sponsors from the public sector will be invited to commission more institutions, countries and service functions to be included into the Register. INTAC draws on the comparative research of the ERC DISCONEX (“The Discursive Const
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Establishing of EEN-services for supporting the Key Account Management process in the SME-instrument and enhancing the INnOvation management capacities of SMEs – KAMINO' under Horizon 2020.

assistant: **Concept**

KAMINO is a package of assessments, proceedings and consultations to give support for SMEs to establish and strengthen innovation management capacities in the small and medium-sized enterprises economy. The project is derived from the Horizon 2020 programme initiated by the European Commission to establish new services of the Enterprise Europe Network consortia in the field of innovation.The objective of the project is first to assess the innovation capacities, innovation processes, innovation strategies and internal organizations of SMEs as well as their relation with innovation partners. Secondly, the project aims to understand the SMEs' capacity in these processes, eventually existing or implemented tools in their innovation management. Thirdly, it is the question of internationalisation. As results of these steps the consultants of the project team are able to identify gaps and bottlenecks and can – jointly with the SME – discuss and define measures and work plans to overcome them.In the following the project aims to support the advised SMEs in their efforts, encourage them and give advice to achieve jointly defined targets.The consortium of four partners, the Industrie- und Handelskammer zu Rostock, the ATI Kueste GmbH, the Steinbeis Forschungszentrum Nordost and the Technologiepark Warnemünde will work on the mentioned activities. The IHK zu Rostock acts only as a coordinator for this specific action. For the realisation of the assessment process the partners will deploy assessment tools with the SMEs in question. The acquisition of the potential SMEs takes place by the selection of suitable enterprises from various sources of the partners and by a selection with a list of criteria for the innovation management enhancement process (EIMC). For the key account manag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Constructing a robust drug delivery system by thermo-responsive gelation and pH-responsive gel-dissolution from triblock terpolymer-drug conjugates' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of this research program is to achieve secure delivery, targeted release and high loading of anti-cancer drugs conjugated with polymers utilizing the following two components. First, the proposed plan involves developing a new polymer-drug conjugate composed of poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA) and anti-cancer drugs containing no amine groups in their chemical structures including docetaxel (DTX). PHPMA is widely conjugated with drugs, and DTX has been reported as an efficient drug for curing solid tumor. However, secure conjugates between PHPMA and such a drug have rarely been reported. Here a new PHPMA-DTX conjugate is proposed where a new PHPMA-peptidyl linker is bonded with chemically modified DTX. The second component involves constructing a triblock terpolymer composed of a thermo-responsive block, pH-responsive block and the new PHPMA-DTX conjugate block to achieve the key target goals in drug delivery. This terpolymer is designed such that it is an injectable solution in water at room temperature. It may form thermo-responsive gels at body temperature during blood circulation (pH = 7.4) due to 3D networking among the terpolymer components above the lower critical solution temperature of the thermo-responsive block. The drugs will be securely delivered to tumor cells with limited exposure to normal cells as one of the gel components. Then when the gels reach acidic tumor cells (pH < 6), the gels will be disrupted and dissolved as the pH-responsive block becomes hydrophobic. As a result, the drugs will be exposed to tumor cells and released by the cleavage of hydrazone bonds and peptide bonds between DTX and PHPMA. Therefore, efficient and precise delivery of anti-cancer drugs will be achieved through this research program. This will only be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Extended Network of CBRN Training Centres for Innovation'.

assistant: **Objectives**

In response to evolving risk landscapes, governments and international organizations have adopted comprehensive programs to enhance preparedness and response capabilities. Building on eNOTICE and eNOTICE-2, eNOVATION addresses the increasing threat of Chemical and Biological threats including Toxin (CB/T) incidents, whether natural, intentional, or accidental, as well as the risk posed by ""Do-It-Yourself"" technologies. eNOVATION aims to expand and strengthen the network of CBRN training centres, including the CBRN Centre of Excellence in regions like the Africa Atlantic Façade (Rabat, Morocco), Central Asia (Tashkent, Uzbekistan), and South East and East Europe (Tbilisi, Georgia, and CBRN CoE partner in Armenia). The project's main goal is to upgrade the training (Trg) framework for first responders in managing CB/T incidents and evaluating on-site emerging tools and technologies for detection, identification, monitoring, and decontamination. eNOVATION introduces new Trg methods that integrate upgraded courses, AI-supported technologies, enhancing automation and user-friendliness, as well as augmented and extended reality (AR/XR). The Network will guide pre-normative research for technologies and Trg methodologies. Altogether, technologies evaluated on-site are sourced from eNOVATION partners, ENCIRCLE, and eNOVATION supplier platforms. The project outcomes aim to integrate human factors and societal considerations into emergency response, including international Assistance to vulnerable and disabled people, assessment of stockpile mobilisation for hospitals in CBRN CoE partner countries during CB/T crises. The web application “eNOVATION Cube” is central to the project: integrating an ontology-driven matchmaking process to serve as a reference and benchmark for traini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Electroanatomical exploration of pulmonary veins sleeve myocardium in the development of atrial fibrillation in ageing and hypertension', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In mammals, the complex anatomical structure connecting pulmonary veins (PVs) with the posterior wall of the left atrium (LA) of the heart, defined as LA-PV junction, is a source of electrical ectopic pulses, which initiate and maintain atrial fibrillation (AF), the most prominent sustained arrhythmia that worsens with tissue remodelling due to ageing and hypertension. PVs’ resident cardiomyocytes generate electrical pulses contributing to arrhythmogenesis within the LA-PV junction. Moreover, “PV myocardium” expresses atrial-specific small conductance calcium-activated potassium (SK) channels, which are involved in AF. Although PVs ectopy is pivotal in AF onset, the pathophysiological space-time dynamic of PV cardiomyocytes’ intermittent firing and the proarrhythmic role of SK-channels in the LA-PV junction have not been investigated in ageing and hypertension. Aim of this project is to define and quantify, for the first time, the intermittent arrhythmogenic pattern of pulses generated by PV cardiomyocytes when challenged by SK-channels antagonists in young adult and aged spontaneously hypertensive rats compared to age-matched healthy rats. Moreover, the three-dimensional electrical heterogeneity of LA-PV spontaneous firing will be described by creating electro-anatomical high-density maps in the aforementioned experimental groups. This project will generate critical knowledge about how LA-PV junction electrically dissociates from sinus rhythm during AF onset and will unveil the role of PVs’ SK-channels in the pathophysiology process of AF. Moreover, this will allow me to acquire new skills to become a successful independent researcher in cardiovascular physiology and electrophysiology of cardiac arrhythmias.


**Keywords:** Pulmonary veins; atrial fibrillation; SK chan