RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Demonstrating a Cloud-based Knowledge Management Platform for Social Business' (KNOWHOW).

assistant: **Concept**

The environment in which modern organizations operate is undergoing a major paradigm shift fuelled by the pervasiveness of ICT and the increasing popularity of social computing. An ever-growing number of organizations are adopting a model of social business, making active use of social media to communicate and engage with key stakeholders. The new social business mindset is redefining many aspects of organizational operations, including how organizations perceive knowledge management. A new, social model of knowledge management (social KM) is becoming increasingly prevalent. Focus is increasingly shifting away from how to best capture and allow access to knowledge, into how to enable knowledge-generating interactions between individuals in the most effective way. In parallel, cloud computing presents new opportunities for developing and provisioning organizational support systems which are always available and facilitate economies of scale.In line with these developments, KnowHow aims to demonstrate a novel Knowledge Management Platform as a Service (KM-PaaS) environment for social business applications, and to prepare the ground for its commercial exploitation.The four main objectives of the KnowHow project are:1. To analyze the social business market environment and to assess the commercialization opportunities for a novel KM-PaaS offering.2. To carry out scale-up activities critical to achieve industrial-grade strength for the KnowHow KM-PaaS, and to implement four new technological solutions based on the platform.3. To validate the KnowHow KM-PaaS through trials in the domains of collaborative innovation, social enterprise, supply chain networking, and social media marketing.4. To develop business plans and marketing strategies supporting the participating SMEs in c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Analysis of the roles of the TRPV2 calcium channel in inflammation' (TRPV2PI3KMACROPHAGE).

assistant: **Concept**

Macrophages are key players in the front line of our immune system, responsible primarily for the recognition and destruction of bacterial and fungal pathogens. However, they are also involved in various inflammatory pathologies. Membrane receptors of chemokines control many aspects of macrophages functions by stimulating various 2nd messenger systems, important amongst these are PI3Ks and Ca2+. However the identity of the Ca2+ channels involved in Ca2+ influx and the cellular responses regulation by that Ca2+ are still poorly understood. The TRPV2 calcium channel is expressed in immune cells, up-regulated during their activation, interacts with some proteins involved in the regulation of the actin cytoskeleton and plays a role in chemotaxis. Moreover, PI3K can regulate TRPV2 activity. The complementary objectives of the project will be to i) define the PI3K-dependant signalling pathways leading to the translocation of TRPV2 to the plasma membrane and its activation, ii) determine the physiological roles of the channel in a native environment. Mouse primary macrophages expressing either i) a TRPV2-GFP construct containing an extracellular flag tag or ii) specific shRNA against TRPV2 will be obtained using the innovative technique of adoptive transfer of haematopoietic stem cells transduced with appropriate retrovirus. Thus we can analyse the subcellular localisation of the channel and its translocation under various conditions. The physiological functions of the channel in macrophages will be precisely analysed in TRPV2-suppressed macrophages using techniques routinely used in the host laboratory. This work will be the first analysis of the endogenous TRPV2 in primary immune cells and will determine if TRPV2 is an important component of the pro-inflammatory signalling n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'JWST + ALMA Dust Enshrouded Star-formation in the Spiderweb protocluster at the cosmic noon' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The distribution of matter within the Universe is defined by a complex multi-scale inter-connected network of filaments known as the cosmic web, with galaxy clusters (i.e., exceedingly dense regions) residing at its nodes. In the early universe (z>2), young forming clusters are observed as strong overdensities of gas-rich dusty starburst galaxies, becoming for a short time the dominant contribution to the star formation rate density before rapidly transitioning towards the massive quiescent population that dominates mature clusters only a few Gyrs later. However, the accompanying large amounts of dust (a byproduct of star formation) heavily obscure such transformative processes, challenging optical observations even with the HST and preventing us from obtaining an unambiguous view of stellar mass growth in early dense environments. The JADES project will overcome such obstacles for the first time by disentangling the star-forming and dust components using deep and high-resolution observations in the rest-frame NIR and (sub-)millimeter regime traced by approved JWST and already available ALMA programs in the legacy Spiderweb protocluster field at z=2.16. In particular, JADES will be the first to establish a full census of star-formation activities (obscured and unobscured) by using the dust-free Paβ star formation indicator (JWST) across the large-scale structure of this protocluster. JADES will also trace the distribution of dust-obscured star-forming regions within previously identified Subaru Hα emitters by making use of their Paβ/Hα ratio (Balmer decrement), and it will map and weight the dust and molecular gas content within individual objects (ALMA) establishing a direct comparison between the star-forming and dusty regions. Altogether, JADES will transform this fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Youth mobility: maximising opportunities for individuals, labour markets and regions in Europe' (YMOBILITY).

assistant: **Innovation**

Research on international youth mobility has been fragmented, mostly based on relatively small samples and case studies. YMOBILITY develops a comprehensive research programme which addresses the following:• Identifying, and quantifying, the main types of international youth mobility in the EU, and their key characteristics. Particular attention will be given to differences between and within three main types: highly skilled, less skilled and students • Understanding what determines which individuals do and which do not participate in international mobility as personal and professional development strategies: their motives, migration channels and information sources• Analysing the individual outcomes in terms of both employability and careers (skills and competences) and non-economic terms (welfare and identities).• Analysing the territorial outcomes for the regions of both origin and destination, in economic, demographic and cultural terms• Differentiating between short-term and long-term outcomes, taking into account return migration and future intentions to migrate.• Identifying implications for policies in migration but also of education, the economy and housing The research will utilise existing secondary data for the whole of the EU, but will mainly rely on primary quantitative data (large-scale surveys to be undertaken by polling agency) and qualitative data (interviews with migrants and returned migrants). The study will focus on 9 countries representing different contexts for youth mobility: Romania, Slovakia and Latvia as sources of emigration and return; the UK and Sweden as destinations for migrants; Germany, Italy, Ireland and Spain as both major destinations and countries of origin. The policy analysis will be informed by interviews undertaken with key info
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transitional Justice Mapping', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In 2009, under the auspices of the ERC, a four year programme of research was launched to look at the legal shaping of memry after two apposite conflicts, both of which were marked by mass atrocity.  One context (the Spanish Civil War) dates back to a 'pre transitional justice' moment.  The other (the Yugoslav conflicts of the 1990's as they effected Bosnia and Herzegovina - hereafter BiH) is largely understood to have been the laboratory of transitional justice.One of the largest and most complex parts of our work in BiH, one that accounts for approximately 30% of our entire 4 year budget and constitutes our first interim milestone, involves a consummate mapping of ‘transitional justice’ initiatives in BiH.  The study is longintudinal, includes a regional purview and aims to chart: i) Flows of funding, personnel and information resources; ii) Target audiences of TJ initiatives; iii) Methodologies involved in research, design and implementation of TJ initiatives; iv) Successes, failures and reduplication of TJ efforts.This ‘map’ already offers an unparalleled resource. However, to expand its utility, this CSA will use social network mapping analysis (through UCINet software) in order to subject the data to a variety of statistical and network-based forms of examination (centrality measures, subgroup identification, role analysis).  This will enable us to identify: i) funding gatekeepers and their target audiences/funding priorities; ii) those actors/institutions that are not easily recognised as ‘central’ but act as integral nodes in the TJ network; iii) clusters of implementing agents and their relation to gatekeepers and significant nodes in the network; iv) the role of certain institutions in coordinating TJ initiatives.The project team believe that the proposed coll
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coordinating chromosome segregation with cell division: the molecular role of mitotic exit network proteins in the regulation of cytokinesis' (2002-2006).

assistant: **Concept**

In all eukaryotic cells, the duplicated sister chromatids are segregated in mitosis by a series of coordinated events such as the alignment of sister chromatids in metaphase, their subsequent segregation in anaphase and division of the cell (cytokinesis). Any defect affecting the order of these events can cause chromosome mis-segregation resulting in chromosome instability, which contributes to the development of cancer through the amplification of oncogenes or the loss of tumour suppressors. It is therefore of fundamental importance to understand the molecular mechanisms that coordinate mitosis. In budding yeast, one such mechanism is provided by a GTPase-regulated protein kinase cascade named the Mitotic Exit Network (MEN). The MEN ensures that mitotic exi t and cytokinesis become dependent on successful segregation of sister chromatids in anaphase.  The molecular mechanisms involved in control of cytokinesis by MEN proteins are still unknown. Components of the MEN are conserved among higher eukaryotes. Mamma lian homologues of yeast MEN proteins, such as Mst2, Lats, Ndr and hMOB proteins, are important regulators of cell morphogenesis, cell proliferation, apoptosis and cytokinesis. In a series of exciting papers, it has been shown that lack of their function p romote tumour formation.  These observations make the functional and systematic analysis of MEN-like pathways an important task.  We will dissect the molecular function of MEN components in cytokinesis by combining genomics, proteomics, cell biology and bioc hemistry in an interdisciplinary approach. Further to our studies in budding yeast, we will analyse MEN homologues in mammalian cells and establish their role in cell division. Thus, this proposal overlaps with the FP6 priority area regarding elucidation o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New ideas for the Variational Approach to Brittle and Cohesive Fracture'.

assistant: **Innovation**

During World War I the English aeronautical engineer A.A. Griffith formulated a theory to explain failure of materials, based on the idea that crack growth is the result of the competition between the surface energy spent to produce the fracture and the energy stored in the uncracked region. Griffith's viewpoint, that by its own nature is variational, found a rigorous mathematical setting in the variational formulation for quasistatic evolutions by Francfort and Marigo, in 1998. Remarkably, this work provides a general framework for several problems in Fracture Mechanics, including post-Griffith theories, in particular the one due to Barenblatt. Griffith and Barenblatt theories differ in the surface energy dissipated in the fracture process: the first is proportional to the measure of fracture set (surface in 3d, length in 2d), the latter depends also on the amplitude of the opening between the two sides of the crack. Microscopically, in the first case (brittle fracture) any material point is either broken or sound, in the latter (cohesive fracture) restorative forces, depending on the opening, are present between the lips of the crack set. Particular choices of cohesive dissipation in the evolution may describe fracture by fatigue.Fatigue occurs when a material degrades by repeated loading and unloading. Fracture by fatigue is extremely dangerous and difficult to predict, since it happens in normal operating conditions without evident warnings. Moreover, it is responsible of about the 90% of failure occurrences. Despite its importance, both the mathematical and the mechanical treatment of fatigue by fracture are much less general than those for brittle fracture.Nevertheless, even the existence of quasistatic evolutions for 3d brittle fracture is still an open problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transitioning Textile Industry Into the 21st Century: the New Generation Needle by Needle Knitting Machine' (NbyN).

assistant: **Innovation**

The knitting machine industry has not evolved significantly in the past 25 years and they use the same mainly mechanical and partially electrical knitting machines today as they did in the last millennium. Based on our 30+ years’ experience in this industry we have developed a new type of knitting machine that can revolutionise the complete industry. Instead of moving the knitting needles using mechanical cams on a predefined route (present solution used by industry), we have integrated miniature stepper motors to move each needle individually (needle by needle). Our innovation results in a faster, more versatile and cheaper machine allowing the production of limitless different designs in a single batch (Just in Time manufacturing). The aim of NbyN development is to take our circular knitting machine for hosiery  to the market (as the market entry point) and through it pilot the technology for the industry. The second step will be to apply our NbyN technology to all type of knitting machines.The potential impact of this development is huge in the long term, but even in the short term we see that the NbyN circular knitting machines for hosiery will generate profits in the region of € 5 million 3 years after the development is completed. We have wide range of networks (over 50 past customers) and have sold over 1,500 custom machines to the industry. Based on feedback from our flagship partners there is a significant need for our innovation (see Letters of Intent from potential customers). This gives us the perfect platform to commercialise our new technology.The aim of the Phase 1 project is to review the market, adjust our business strategy (licencing or distribution) and prepare for product development under the Phase 2 project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advancing the Combustion of Hydrogen-AmmonIa blEnds for improVed Emissions and stability' (ACHIEVE), addressing dissemination and exploitation.

assistant: **Impact**

To mitigate the impact of greenhouse gas on the environment and climate, the gas turbine power generation industry must rapidly reduce its emissions. This requires abandoning the traditional combustion of carbon-based natural gas in favour of carbon-free fuels. ACHIEVE aims at developing the fundamental knowledge to enable a transition to unconventional carbon-free fuel blends based around H2 and NH3 to achieve zero carbon emissions, ultra-low NOx emissions, and stable gas turbine operation. ACHIEVE proposes a three-pronged strategy consisting of (a) experimental and (b) numerical activities, that will advance the technology readiness level (TRL) up to 4 for practical low emissions combustors for realistic and representative blends of fuels, as well as (c) system level engagement with OEMS, end users, and stakeholders. Experimental campaigns will explore combustor stability limits, emissions, and fundamental aspects of the combustion of hydrogen blends, with the complexity of the experimental burners and operating conditions increasing over time and culminating in tests performed at intermediate pressures and powers relevant for gas turbine conditions. Numerical activities will address combustion modelling challenges, including chemical kinetics, fundamental physics governing flame dynamics, ushering in new modelling techniques such as artificially thickened flames coupled with virtual chemistry, sub-grid LES models for thermo-diffusive instabilities and stability analysis aimed to understand and predict NOx formation mechanism, lean blow off, flashback limits and thermoacoustic instabilities. Real-time monitoring and predictive capabilities for practical combustion systems will also be developed. Finally, in the third prong, engagement with industry, OEMs, and other ta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Uncovering novel metabolism, microbial interactions and environmental roles of electroactive ANaerobic MEthanotrophic archaea' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Anaerobic methanotrophic (ANME) archaea are ecologically critical microorganisms that remove methane from natural environments, thereby reducing emissions of this potent greenhouse gas. However, their physiology and ecology remain vastly unexplored due to the lack of axenic (single species) cultures of ANME archaea, their slow doubling times (in the order of weeks or months) and their complex nutritional requirements and interactions with other organisms. Recently, we achieved a breakthrough in ANME archaea cultivation, developing bioelectrochemical systems with highly enriched (>95% pure) and rapidly growing (doubling time ~4.5 days) cultures of Ca. Methanoperedens, a representative freshwater ANME archaeon. Now, in electroANME, we propose to leverage our expertise in growing and characterizing ANME archaea and our unique access to these near-axenic cultures to address urgent scientific questions related to microbial methane removal. In Aim 1, we will elucidate the molecular mechanisms involved in methane oxidation, particularly by elucidating how ANME archaea perform extracellular electron transfer to electron acceptors. In Aim 2, we will identify bacterial partners of ANME archaea and delineate the mechanisms involved in direct interspecies electron transfer between ANME archaea and bacteria. In Aim 3, we will explore the metabolic diversity of ANME archaea, including in the absence of external electron acceptors, and probe the environmental relevance of these metabolic processes. The findings from this project will not only provide novel insights into the physiology and ecology of ANME archaea but also have the potential to improve climate models and inform future biotechnological applications exploring the capacity of these microbes to oxidize methane, thereby help