RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Quantitative chemical analysis of polymer surfaces coated by plasma enhanced chemical vapour deposition' (POLPLASCOAT).

assistant: **Innovation**

Technological polymer surfaces coated by plasma enhanced chemical vapor deposition (PECVD) for improving hardening or barrier application performances for packaging and optics are quantitative characterized by XPS, ToF SIMS, AFM and PM FTIR ERS at high chemical, molecular and spatial resolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Redefining the esophageal stem cell niche – towards targeting of squamous cell carcinoma', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cancer develops from mutations in stem and progenitor cells. Patients suffering from esophageal squamous cell carcinoma are commonly treated by a combination of chemotherapy and esophagectomy, a debilitating surgical procedure. My group have identified heterogeneity within the esophageal progenitor population in homeostasis which is likely to have implications for the development of squamous cell carcinomas of the esophagus, lead to targeted therapeutic strategies and hopefully reduce the need for surgical intervention.    Stem and progenitor cells reside in a complex microenvironment, or niche, that is instructive in determining cell fate during homeostasis and tumor initiation. In the morphologically uniform esophageal epithelium, the presence of progenitor subpopulations cells as well as local microenvironmental niches is not evident. My group aim to not only delineate the functional heterogeneity within the esophageal progenitor population during homeostasis and cancer development, but also map out and eventually target the stromal niche cells driving this phenotypic epithelial heterogeneity. Furthermore, we will use a clinically relevant platform to screen for druggable targets with the ability to eliminate esophageal tumor initiating cells.   The incidence of human esophageal squamous cell carcinomas is dramatically increasing, and delineation of the esophageal stem cell niche is a vital first step towards identifying new combined therapeutic strategies directed at eliminating this cancer.


**Keywords:** Stem cell heterogeneity, origin of cancer, mouse model, human organic screening, epithelial-to-mesenchymal crosstalk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Study on databases of women scientists' (DATAWOMSCI), addressing dissemination and exploitation.

assistant: **Impact**

Networks and databases are an important strategy to promote women in science and to increase the percentage of women in top positions in the scientific field. While there are projects covering networks, an international cooperation and linking of mostly na tional databases is still missing. The promotion of women scientists is urgently needed and databases are an effective means to achieve this. The study will result in presenting the bases to build up co-operations. It comprises three tasks concerning datab ases of women scientists: 1.a structured coverage and an overview of databases, 2.a feasibility study on the technical possibilities of linking databases, 3.the development of criteria of quality and formulation of recommendations for building up new da tabases. In order to ensure the adequate participation of women scientists in the 6th Framework Programme and in the building of the European Research Area, the internationalisation and collaboration of women scientist is urgently needed. Databases are an effective means to achieve this aim. For databases to be used efficiently by women scientists and organisations, they have to meet certain criteria of quality. A catalogue of relevant criteria for a high quality database will be presented as one of the res ults of the study. It will also include best practice examples for those countries wishing to build up new databases. The availability of recommendations, including a technical background, can also facilitate any plans for a database possibly accompanying the European Platform of Women Scientists in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The aftermath of slavery in East Africa' (ASEA).

assistant: **Concept**

Legacies of slavery tend to affect societies deeply, but in inland East Africa have remained little explored. This project aims [1] to establish what happened to the hundreds of thousands of slaves present in mainland East Africa in ca. 1900 and to their descendants over the twentieth century, [2] to explain why the aftermath of slavery is so little discussed in the written sources and historiography of the region, and [3] to trace the social and political legacies of slavery up to the present. It will combine historical and anthropological methods, and, besides post-slavery, addresses questions pertaining to public history, social mobility, marginality and inequality, gender, and understandings of freedom. It pursues them through a series of place-specific case-studies tracing different courses and outcomes within the region, and through comparative work, both between the case studies and with studies on the aftermath of slavery in West Africa, the Indian Ocean and the Americas. The project is ground-breaking through its long-term time frame, its wide-ranging combination of methods, and in questioning established assumptions, e.g. about the meaning of ‘freedom’ for ex-slaves. It is high-risk in the sense that the field researchers leading the case studies will need good knowledge of Swahili, good social contacts and the flexibility to identify and follow emerging leads wherever they take them. It is feasible because the proposed research program and conceptual frameworks can be adapted as the work develops, and given the obscurity of the regions, groups and questions involved, the resulting gains to knowledge will be major. It is high-gain because it will fill a gaping hole in current knowledge, and establish how people in East Africa coped with the toxic legacy of sla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'EURopean Endeavour for Chimeric Antigen Receptor Therapies'.

assistant: **Concept**

Cancer is rapidly becoming the most frequent cause of death in EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are major causes of chronic diseases. Adoptive immunotherapy with T cells genetically modified with a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer without causing secondary chronic diseases. This approach is already at an advanced stage of development in the US, but struggles in the EU, due to a number of constrains that will be specifically tackled by this Project. The ultimate goal of EURE-CART is to bring EU at the forefront CAR T-cell immunotherapy. In this Project, we will extend the applicability of CAR T-cell immunotherapy to incurable tumours that have never been tackled with this approach. The EURE-CART Consortium is composed of 6 academic centres, 2 SMEs and 1 large enterprise from 6 EU countries, clearly representing excellences in their respective fields. EURE-CART will bring together clinical experts in oncology, and pioneers and leaders in the field of cell and gene therapy for starting the conduction of a first-in-man Phase I/II clinical trial. To be successful, EURE-CART proposes the early involvement of National regulatory authorities for accelerating the approval of CAR T-cell immunotherapy, as well as the centralisation of its production by the AGC Biologics (formerly Molmed SpA), which is uniquely endowed in the EU with the knowhow and experience necessary to meet this ambitious objective, as demonstrated by its unparalleled track record. The main expected impact of EURE-CART is the establishment of CAR T-cell therapy as the ultimate personalised therapy, capable of defeating chronic diseases, and to create secure new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Getting more Asian Participants involved in IST Calls' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The aim of the GAPFILL Project is to contribute to one of the priorities of the IST Programme: reinforcing Europe's position in IST on the international scene. The Project also contributes to reach another objective of the IST Programme: getting a high level of participation of organisations from third countries in FP6 IST Projects. To support these objectives, the GAPFILL Project is focusing on four Asian countries: Singapore, Malaysia, Thailand and Taiwan. They have been selected for the prospects of their IT markets, the quality of their IT communities, their low level of participation in the 1st IST Call of the 6th FP, the determination of their authorities to develop S&T cooperation with Europe in the IT field, and because of the small number of initiatives that the IST programme has so far developed in these countries. The GAPFILL Project is short in time and intense in terms of activities. An information day is first organised in Europe to promote the initiative among the EU ICT community. A two-day event is then organised in each of the four targeted countries. Emerging cooperation Projects are then given assistance by a GAPFILL help-desk. All along the project lifetime, marketing and promotion activities provide the support the other activities require: press conferences to be organised in the four selected countries, a specific web site, project documentation to be widely disseminated, etc. The GAPFILL Project partners are Sigma, Project coordinator, the Taiwanese National Science Council, the Singaporean Agency for Science, Technology & Research, the Malaysian Mimos Berhad and the Thai National Science and Technology Development Agency. Important, concrete results are expected: the effective increased participation of Asian organisations in coming IST Calls,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Randomness in proof theory, model theory, and computation'.

assistant: **Concept**

Research objectives and content The main objective of the application is to enable the applicant to connect his research with other areas, in cooperation with researchers from M|nchen. The previous research of the applicant was concerned with randomness in computability theory and with learning theory. In addition to a continuation of part of this research, new research is sought in the direction of model theory and proof theory. Training content (objective, benefit and expected impact) The LMU in M|nchen constitutes an excellent training environment for the applicant, in particular when seen in light of his plans to learn more proof theory. Links with industry / industrial relevance (22) The Formal Methods Group of Corporate Research of Siemens AG participates in the Graduiertenkolleg 'Logik in der Informatik'. In this context, one of Schwichtenbergs doctoral students (Monika Maidl) is supported by a grant form Siemens. Beginning next May another student of Schwichtenberg (Holger Benl) will begin working on a PhD project in cooperation with BMW.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Space variant visual sensor-with colour acquisition' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of this project is to demonstrate the feasibility of a space-variant silicon sensor with color acquisition capability.To achieve this goal we intend to investigate two different technological approaches:- The integrated' approach where we intend to use a color deposition process to modify some of the currently available CMOS chip (it is not required to fabricate a new chip).- The "system'' approach where we intend to use a new technology based on ferroelectric liquid crystal (FLC) based color filters (available on the market). This device allows to electrically change the color characteristics of the filter (mounted either on the chip or the camera lens) and, in particular, to acquire the red, green and blue components of a scene using a B/W camera.The two solutions have, of course, advantages and disadvantages. The integrated solution is, in perspective, the most interesting one.Among the pros: i) cost will be lower, ii) the system will be simpler, iii) the technology for color chip fabrication (particularly for special purpose applications) is strategically important for the European industry. On the converse, the deposition of color micro filters, reduces the resolution of the overall image and, therefore, requires, a comparatively higher number of pixels.The "system" solution has the advantage of exploiting all the spatial resolution available on the chip at the expenses of a higher cost and complexity. The reduced temporal resolution (required to acquire the sequence of RGB components) is not really a problem because, due to the relatively small number of pixels acquired by a space-variant sensor, the ``absolute'' frame rate can be higher than conventional cameras (with the same technology) providing, at the end, the required frame rate.The first phase of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Brenner Rail Freight Action Strategy Aimed At Achieving A Sustainable Increase Of Intermodal Transport Volume By Enhancing Quality, Efficiency, And System Technologies' to be submitted under Sixth Framework.

assistant: **Abstract**

The BRAVO Project has been conceived to meet the challenges set by the increasing demand on logistic systems, railways liberalisation, lack of efficiency in intermodal transport, congestions and infrastructural bottlenecks on major transport routes in Europe. The objective is to develop and demonstrate an action strategy on rail freight and intermodal rail-road services. BRAVO will lay foundations for achieving a significant and sustainable increase in intermodal volume on the Brenner corridor, but it shall also be designed as a blueprint applicable to other pan-European freight corridors.The primary strategic aim of BRAVO, i.e. the elaboration of a Brenner Corridor Action Strategy, composes of the following scientific and technological objectives:- Development of a coherent corridor management scheme enabling open access- Blueprint for an interoperable rail traction scheme involving multi-current locomotives- Development of an EDP-supported quality management system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DNA replication timing and spatial organization of chromatin' (REPTIMORG) targeting Horizon 2020.

assistant: **Abstract**

Replication timing is observed in all eukaryotes analyzed so far suggesting an important and conserved function. Despite significant advancement in the field, the molecular control of the replication-timing program is still largely unknown. The Buonomo laboratory has recently done very innovative work in this area. After identifying Rif1 as the only known global regulator of replication timing in mammalian cells, they have further shown that Rif1 controls chromatin architecture during replication-timing establishment. This provided the first molecular evidence linking 3D nuclear organization and replication-timing control. However, Rif1 is a complex protein whose structure-function is not fully understood and it is not clear yet if the link between 3D nuclear organization and replication-timing control is specific to Rif1 or a general paradigm. A major aim of this proposal is to investigate if chromatin architecture plays a general role in replication-timing control. To this end, I will perform replication-timing and chromosome-conformation studies using mouse models which allows me to conditionally delete genes encoding for key regulator of nuclear structure, such as cohesin (Rad21) and Lamin B1. I aim with this proposal to advance the understanding of how spatial organization of chromatin regulates and integrates different nuclear functions, with a specific focus on DNA replication.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel sol gel technology for long length superconducting coated tapes' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The project aims to develop a Sol - Gel methodology for fabricating YBCO - based super conducting tapes which can be exploited at 77K in magnetic fields up to 4-5 T. The goal is to reach high performance (Jc = 1MA/cm² at 77 K) coated conductors at low cost and demonstrate their suitability in the fabrication of power devices. Novel sol gel and/or metal. organic precursors used to prepare oxide buffer and YBCO layers will be investigated. A spray coating system for continuous deposition will be installed and the oxide growing conditions for biaxial texture over metallic substrates will be determined. Two types of metallic substrates will be investigated : RABiT Cu/Ni, with electrodeposited protective layers when necessary, and polycrystalline stainless steel with a very thin seed IBAD layer. Two demonstrators - a cable & a magnet component will be fabricated using the newly obtained tapes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Just because we can, should we? An anthropological perspective on the initiation of technology dependence to sustain a child’s life' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

There is an increasing number of children with complex healthcare needs who require continuous technological support to sustain their lives. This technology dependence is initiated in an environment of medical interventionism, with potential for discrete discrimination. A scarcity of empirical data on the influences and interactions at the point of the initiation of technology dependence means that clinical, legal and ethical deliberations are driven more by opinion than empirical evidence. An evidence-based theoretical construct is required to articulate and contextualise the levers and penalties of the initiation of this technology. TechChild asks just because we can, should we? and how are the influences on the initiation of technology dependence understood in contrasting health, legal, and socio-political systems? Serendipitous findings from my research indicates parental concern regarding an absence of transparency, and parents are questioning patterns of family characteristics, when technology dependence is initiated. TechChild will be a step change in how we understand the coexistence of humans with an increasing availability of technological augmentations. This is urgent in a society where this debate predominantly happens in the public domain with limited opportunity for healthcare professionals to offer their perspective. TechChild will revolutionise how we conceive access to care and offers a research horizon that questions cultural relativism in a cyborg era. This is a scholarly ambitious project involving Paediatric Intensive Care Units in four international sites using a Bayesian framework to elicit the probability of factors likely to influence the initiation of technology dependence, leading to the development of a theory of technology initiation. This g