RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering tumor-promoting mechanisms mediated by neutrophils in vivo' to be submitted under Horizon 2020.

assistant: **Abstract**

Immunotherapies are revolutionizing cancer care, but are only effective in a minority of patients. Because current treatments typically target T lymphocytes, manipulating other cell types will create additional therapeutic opportunities. This research project aims to study neutrophils, because they can be abundant in the tumor environment, can modulate tumor outgrowth and response to treatments, and are candidate new therapeutic targets. However, tumor-associated neutrophils can be phenotypically and functionally heterogeneous, with only some of them promoting tumor growth. At present, we have a limited understanding of the complexity of neutrophils in tumors, and the mechanisms that control the functions of these cells. This is largely due to the inherent experimental limitations of neutrophil studies.  Here, we will use a new approach to test the hypotheses that so-called Conditionally-Immortalized Neutrophil Progenitors (CINP) can be: 1) used to produce unrestricted numbers of tumor-associated neutrophils in vivo, and 2) gene-edited to study neutrophils mechanistically during cancer progression. Addressing these questions bears scientific and therapeutic importance, as it will not only deepen our fundamental understanding of the mechanisms regulating neutrophil activities in cancer, but also indicate new molecular targets for therapy.   With this study, I will also create and share a publicly available database of all newly identified targets that will be investigated by us, other academic research groups, and industry. Besides, the project’s outputs will be communicated to the broader general public. Altogether, the training and input I will receive during the Marie Curie Individual Fellowship will prepare my transition from post-doc to independent researcher in an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Investigation of LTE-Advanced for Network Behaviour, Energy and Intelligent Transportation Systems""'.

assistant: **Objectives**

The usage of new internet-based services with the wireless mobile devices has an unlimited potential as we have just witnessed in the Egyptian revolution and disaster relief in Haiti.  However, currently available wireless cellular technology 3G has been unsuccessful in delivering multimedia with acceptable level of quality due to the low transmission rate and high service costs.  Thus, a 4G standard LTE-Advanced has been developed intended for larger capacity and higher speed of mobile networks. However, despite its promising potential, LTE-Advanced-based technology is still at infant stages and there is much work need to be done for wider commercial operation. The objective of this application is to advance 4G-based wireless mobile network utilizing multidisciplinary research approach. It is a step toward attainment of my long-term career goal, which is to further develop my expertise in wireless network communications while advancing academic career. The motivation of the project is that evaluating LTE-Advanced-based protocols and applying the technology for practical applications will improve our mobile communication. The rationale for the proposed research is that once effective LTE-Advanced-based technologies are established, it enables a wide range of commercial operation throughout the world thereby stimulating economy in EU countries where major mobile communication industries are concentrated. Furthermore, the general population will be benefited from 4G-based mobile communication services, which are currently not available e.g. Intelligent Transportation Systems.  I plan to accomplish my objective by pursuing the following Workpackages (WP): Specific WP1) Evaluate LTE advanced protocols to identify potential bottleneck of LTE network, Specific WP2) Develop an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'CHARACTERIZATION AND SUSTAINABLE USE OF EGYPTIAN DEGRADED SOILS'.

assistant: **Innovation**

SUDSOE intends to increase the scientific regional leadership, to pursue, transfer, and provide the most advanced technology in the fields of remote sensing and peaceful application of space sciences applied to the characterization and sustainable use of Egyptian degraded soils, and build the self-capability to utilize these technologies to support the National development activities. Such challenges will be achieved through reinforcing its excellence and creativity contributing to regional economy and social welfare in line with EU2020 Strategy, which sets priorities on developing an economy based on knowledge and innovation.NARSS demonstrate high level of human, material and organizational capacity as well several collaboration experiences with European and African countries, but SWOT analysis indicates some weaknesses to be faced in order to reach the scientific regional leadership. Based on the SWOT analysis and in accordance with the Work Program of the call, coherent set of measures are elaborated. Full research potential will be realized in close cooperation with 3 outstanding EU partnering organisations (POs) in the same S&T domain. The NARSS human will be enhanced by: developing strategic partnership with POs, by transferring and sharing of experience and knowledge; - recruitment of experienced researchers to prevent brain drain; - dissemination and promotion of acquired knowledge at national, regional and international level, especially in the MED region. SUDSOE outcome is related to diverse beneficiaries, such as scientific community, general public, local authorities, policy makers and diverse stake-holders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a high-resolution printing process for cost-effective production of ultra-fine line electronic circuitry' (HI-RECIPRI).

assistant: **Concept**

Screen printing is currently used in the production of electrical circuitry. For ceramic-based electronic modules electrically conductive lines are printed directly, while etch/solder resist patterns currently are being printed in Printed Circuit Board (PCB) production. Printing is chosen for its large production speed, small number of processing steps and very efficient use of material. The width of the printed lines in industrial production is however limited to about 150 m Line widths down to 50 pm have only been obtained on small planar substrates with use of special stencils. New applications require narrower lines (down to 25 m) on up to 50x60 cm2 substrates, and options for using non-planar substrates. For this reason, complex photolithographic processes have been introduced. They are however slow and are environmentally unfriendly because of the required additional development and drying steps and because of the less efficient use of material. The resulting cost penalty is of order factor 210, which often prohibits their use in e.g. consumer products.Therefore, a novel offset printing process will be developed that has many benefits:- printing of very fine line circuitry - miniaturisation of products;- few processing steps;- efficient use of material;- decreased energy need- cost reduction- environmental benefit - environmental benefit - increased market share.Results of the project will be:1. Novel, reliable, low cost, printing process for printing conductive and resist patterns in the production of ultra-fine line circuitry (line width down to 25 m and height up to 15 m);2. Novel conductive inks for the fine-line printing of electrical circuits on ceramic (allowing curing at high temperature) and on PCB substrates (here, curing must be done at <200ÐC);3. Novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fundamentals Of Photocatalytic Splitting of Water' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Hydrogen produced by sunlight is a very promising, environmentally-friendly energy source as an alternative for increasingly scarce and polluting fossil fuels. Since the discovery of hydrogen production by photocatalytic water dissociation on a titanium dioxide (TiO2) electrode 40 years ago, much research has been aimed at increasing the process efficiency. Remarkably, insights into how water is bound to the catalyst and into the dynamics of the photodissociation reaction, have been scarce up to now, due to the lack of suitable techniques to interrogate water at the interface. The aim of this proposal is to provide these insights by looking at specifically the molecules at the interface, before, during and after their photo-reaction. With the surface sensitive spectroscopic technique sum-frequency generation (SFG) we can determine binding motifs of the ~monolayer of water at the interface, quantify the heterogeneity of the water molecules at the interface and follow changes in water molecular structure and dynamics at the interface during the reaction. The structure of interfacial water will be studied using steady-state SFG; the dynamics of the water photodissociation will be investigated using pump-SFG probe spectroscopy. At variable delay times after the pump pulse the probe pulses will interrogate the interface and detect the reaction intermediates and products. Thanks to recent developments of SFG it should now be possible to determine the structure of water at the TiO2 interface and to unravel the dynamics of the photodissocation process. These insights will allow us to relate the interfacial TiO2-water structure and dynamics to reactivity of the photocatalyst, and to bridge the gap between the fundamentals of the process at the molecular level to the efficiency o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Imaging dendrites across wake and sleep: fiberoptic measurements of calcium activity in freely behaving animals' (PERISLEEP), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to look at changes in dendritic calcium activity during sleep and how these changes are influenced by waking experience in freely behaving animals. Sleep promotes brain plasticity and processes dependent upon plasticity (i.e. memory consolidation). But the cellular events that mediate these effects are poorly understood. We hypothesize that sleep promotes brain plasticity by increasing synaptic activity locally. We will test this hypothesis by looking at changes in in vivo dendritic calcium transients during sleep (Aim1) and sleep-dependent cortical plasticity (Aim2) in freely behaving animals. This will be achieved by combining EEG/EMG polysomnography recording and fiberoptic imaging techniques. More specifically, we will look at changes in calcium activity from the apical tuft dendrite of layer 5 pyramidal neurons. Dendrites are the main site of information processing and integration therefore changes observe over the sleep-wake cycle will contribute to a better understanding of synaptic function in the intact brain (Aim1).  Changes in dendritic calcium levels are also directly linked to neuronal activity and can predict the polarity of plastic changes (e.g. synaptic potentiation vs. depression). Therefore, we expect that challenging the brain during wakefulness will modify dendritic activity during subsequent sleep. To test this hypothesis, we will quantify dendritic calcium activity during sleep following 2 different experience-dependent plasticity paradigms leading to either potentiation (enriched environment) or depression (monocular deprivation) in primary visual cortex (Aim2). The proposed research would be the first to assess directly the effect of sleep, experience-dependent plasticity and sleep-dependent plasticity on in vivo dendri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cryo-CLEM in situ imaging of adenovirus stepwise disassembly' (CryoCLEMAV) targeting Horizon Europe.

assistant: **Abstract**

Adenoviruses (AdVs) are very contagious viruses widespread in vertebrated. Human AdVs infections mainly affect children and immune-supressed people. On the other hand, AdV-derived vectors, nanocarriers and vaccines have turn out to be efficient therapeutic tools. Understanding AdVs disassembly mechanisms is vital to advance research in antiviral drugs, gene therapies, nanocarriers and vaccines. AdV particles’ metastability is key for surviving environmental conditions and cell defences, but at the same time, these particles should disassemble at the appropriate time and place during virus entry. The particle size and the speed of the process challenges the visualization of these events inside the cell. CryoCLEMAV aims at providing unprecedented structural insight on the process of virus entry and disassembly by combining virology with the cutting-edge microscopy techniques: correlative light and electron microscopy (cryo-CLEM), cryo-electron tomography (cryo-ET), FIB-milling and subtomogram averaging. This approach will allow to recapitulate the process with a previously unreachable resolution and specificity in a near native context of the host cell. CryoCLEMAV is an ambitious project whose success will be firmly supported by merging my expertise in virology and super resolution microscopy with the host lab knowledge and resources in cryo-EM techniques and adenovirus biology. Outcomes of this project will contribute to the development of several cryo-electron microscopy techniques and to the field of adenovirus biology, also impacting in the expanding field of adenovirus-derived therapeutic tools. All together will advance the research work of my host group, benefit the host organization (CNB-CSIC), and boost my professional career.


**Keywords:** Cryo electron micros
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SECURE-BY-DESIGN IOT OPERATION WITH SUPPLY CHAIN CONTROL' (DOSS) under Horizon Europe.

assistant: **Objectives**

DOSS elaborates a secure-by-design methodology and implements related technology for complex IoT architectures, based on supply chain monitoring, component testing and architecture modelling. The project establishes a “Supply Trust Chain” with integrating key stages of the IoT supply chain into a digital communication loop to facilitate security related information exchange. The technology includes security verification of all hardware and software components of the modelled architecture. A new “Device Security Passport” will be defined for 3rd party hardware and its components. 3rd party software, open-source applications, as well as in-house developments will be tested and assessed. The centrepiece of the proposed solution is a flexibly configurable Digital Cybersecurity Twin, able to simulate diverse IoT architectures. It will employ AI for modelling complex attack scenarios, discovering attack surfaces, and elaborating the necessary protective measures. The digital twin will provide input for a configurable, automated Architecture Security Validator module which will assess and provide pre-certification for the modelled IoT architecture in respect of relevant, selectable security standards and KPIs. To also ensure adequate coverage for the back end of the supply chain the operation of the architecture will also be protected by secure device onboarding, diverse security and monitoring technologies and a feedback loop to the digital twin and actors of the supply chain, sharing security relevant information. The procedures and technology will be validated in three IoT domains: automotive, energy and smart home.This new secure-by-design approach for complex IoT operations will be an early implementation of the concept and requirements of the proposed European Cyber Resi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'TREATMENT OF WASTEWATER FROM CHEESE MANUFACTURE'.

assistant: **Objectives**

Waste waters from cheese making always need treatment as the pollutant loads are particularly high and variable and the fluctuations in flow generate many difficulties for the treatment of effluents. The problems are amplified by the aggressive products used for the washing and disinfection of production lines. Currently no process that can solve these problems exists on the market. Traditional processes proposed by the large operators do not provide solutions technically and financially acceptable to small and medium sized companies active in the cheese making sector. Current treatment processes need large scale expensive plant which do not operate well when pollutant loads vary.This project used a process developed by two SME's (one from Luxembourg and the other from Austria) and commercialised in their own countries. The process (2 stage activated sludge with specific recirculation of primary and secondary sludges) promoted Euroleaders 94 (DG XVI) and showed exceptional qualities enabling it to meet different applications for water coming from industrial activities such as food processing.The objectives of the project were to:- adapt a two stage activated sludge process to the specific conditions and qualities of the waste waters produced by milk, milk powder, butter production- demonstrate the high performance in biodegradation of organic matters and elimination of nitrogenous and phosphorous components- demonstrate the stability of the process changing organic and hydraulic outputs- show the reduced investment needs, due to the compact plant (total treatment volume reduced up to 50% compared to classical processes)- show the low exploitation costs- use the reference plant and its results for developing other projects in industrial and/or agro-food waste water treat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Neural coding of fear memories formation and extinction in frontal association network' in the context of a Seventh Framework call.

assistant: **Objectives**

The neocortex is the brain area that is most expanded in the human brain. It is thought that neocortical function underlies the remarkable adaptive and associative learning skills of mammals. Learning-dependent neocortical plasticity is supposed to rely on subtle changes in the spatial pattern and level of neuronal activity that likely depend on connectivity rearrangement through synapses turnover and/or activity-dependent strengthening and weakening of pre-established synapses. However, whether this structural-functional cascade occurs in higher cognitive frontal areas during associative stimulus learning is currently not known. By combining in vivo two-photon long-term structural imaging of dendritic spines, large-scale neuronal calcium imaging, and whole-cell recording in the behaving animal, we aim at understanding how the formation and extinction of associative fear memories are implemented by neuronal circuits in rodent frontal association cortex (FrA). Understanding of how different neurons in higher cortical areas modulate the structure of their connections in response to learning, and how this would alter the cortical processing is a key to understand how we store information and acquire new skills, and potentially help to advance the design of new strategies toward memory enhancement and neuronal repair in a wide range of brain diseases.""