RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Developmental Crosstalks between Microglia,  Blood-Brain Barrier and Maternal Microbiota' to be submitted under Horizon Europe.

assistant: **Abstract**

Brain functioning can be influenced by body ecosystem signals conveyed through the vasculature and regulated by the blood-brain barrier (BBB), a selective and modulable barrier that controls which substances and cells enter the brain. Structural or functional BBB deficits are found in many brain diseases, from neurodevelopment to neurodegeneration, thus understanding how the BBB develops holds critical significance for both biologists and clinicians. Yet, we still lack fundamental knowledge on how interactions between different cellular populations in coordination with environmental signals contribute to BBB construction during early development.To tackle this issue, we will focus on the core components of the BBB -pericytes and endothelial cells- and microglia, the brain resident macrophages. Microglia play key roles in circuit assembly and we have shown that prenatal microglia, which are in close apposition to the vasculature, respond in a sex-specific manner to signals derived from the maternal microbiota.Here, we will study the developmental crosstalk between microglia and BBB in both male and female embryos by investigating (i) how pericytes influence prenatal microglia; (ii) the spatiotemporal heterogeneity of BBB closure and implication of microglia; and (iii) the impact of maternal microbiota on BBB formation and crosstalk with microglia. Our approach leverages multidisciplinary and state-of-the-art techniques in newly developed murine models of microglia depletion and in utero antibiotic treatment, including two-photon live imaging, single-cell and spatial transcriptomics, in vitro BBB model and comparison to human embryos. Ultimately, we will establish an integrated framework of BBB formation and BBB-microglia interplay, shedding light on how signals from mate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Nex hygenic cleaning technique - for food production - reducing aerosol problems and water consumption (AEROSOL REDUCTION)'.

assistant: **Objectives**

Food-, pharmaceutical- and agricultural- industries allover the world, use high pressure water cleaning to get rid of contamination, micro organisms and bacteria. Enormous amounts of water and energy are used every day for different cleaning purposes. Still many people get serious ill/poisoned every year, due to hygienic problems contamination. Investigations show that a huge problem is contamination of already cleaned equipment. This contamination is a result of aerosols, spread all around the plant. The major route of contamination of food during production is by air. Micro organisms are normally transmitted through the air incorporated in particles and water droplets (aerosols) which is a result of the cleaning actions. Aerosols are fine, moisture droplets. Aerosol can be generated from the cleaning operations. This type of contamination may be a potential source of Listeria. The wish from the authorities in EU and other parts of the world is to assure the cleaning process avoid contamination and to reduce the water consumption. The overall objective is to develop a vacuum based cleaning system as a replacement for todays water wasting system. The objectives are to avoid harmful contamination and to reduce the total water consumption with about 40 %. The RTD will concentrate on solving the technical problems in the vacuum based cleaning system how to measure collect the aerosols and reduce the spreading Results-exploitation The result will be a new cleaning system for food and pharmaceutical industries. The SME proposers will exploit the results by selling the system in north Europe and UK. SMEs in other countries will be able to buy production sales licences. Exploitation and dissemination of result will start in 2006. The market for this new cleaning system is very
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Zinc-Air flow batteries for electrical power distribution networks' in the context of a Seventh Framework call.

assistant: **Objectives**

The concept of the project is to create a new class of electrical energy storage system with the unique combination of characteristics of high energy density, modularity, fast response and low cost. To achieve these aims, the project will radically extend performance of a zinc – air batteries from small scale single primary cells to rechargeable redox flow battery modules, which at production scale can be stacked to give powers of 20 kW to MWs.At all stages of the project, a system approach will be adopted to develop a working and robust energy store from the individual components (flow battery, power conversion, grid interconnection, control system) which is suitable for industrialisation within a short timescale at the end of the project.The project will be steered by analysis of the user applications and requirements, leading to system specifications for potential applications, which will in turn define targets for the individual system components.The rechargeable Zn-air battery proposed here will overcome many of the problems of other storage technologies including conventional redox flow cells by the introduction of the following innovations: the use of an air electrode for one half-cell reaction (only half the reactant volume is required), increasing energy density, use of an alkali electrolyte in which the metal is highly soluble allowing high energy densities with fast electrode kinetics, fast response due to the fast electrode kinetics and the reactants being already present at the electrodes, decoupling of power and storage capacity due to the external electrolyte storage, low cost (due to the cheap electrolyte & simple material requirements), highly scalable and modular using distributed power electronics.A 10 kW demonstrator will be built which will be fully
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of Glial cells in the control of puberty' (Glial-Puberty) under Horizon 2020.

assistant: **Objectives**

Puberty, a key developmental period when the reproductive capacity is attained and sexual and somatic maturation completed, is under the control of a complex series of regulatory mechanisms that are sensitive to endogenous factors and environmental cues. However, characterization of the neuro-hormonal basis of puberty remains incomplete. A wealth of evidence has demonstrated the existence of reciprocal communications between glial cells and neurons; glial cells having an essential role in regulation of the functional activity of the nervous system. In this context, it is well establish that glial cells play an important role in neuroendocrine regulation and participate in sexual differentiation of neuronal connectivity of brain regions involved in the control of puberty. In addition, preliminary studies have demonstrated that kisspeptins induce changes in markers of glial cell activity. Based on this preliminary data, the aim of this proposal is to provide better knowledge of the role of glial cells in the control of puberty and their interplay with kisspeptins, as major gatekeepers of puberty onset in mammals. To this end, we will used both Kiss1 KO and Gpr54-βgal models generated by the host laboratory, which will allow the study of direct effects of kisspeptins on glial cells. In addition, we will generate a mouse model with deletion of Gpr54 (kisspeptin receptor) only in glial cells, to define their precise role in the control of puberty. Implementation of this project will expand our knowledge of the mechanisms for the control of puberty and its deviations, whose prevalence has notably increased worldwide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Surface phenomena and reactions' (SURPHARE).

assistant: **Innovation**

The surface science has growing importance in research in view of its significance in different areas of technology. Establishing of SURPHARE joins together groups of scientists from the Institute engaged in surface science. The aim of the Centre is scientific cooperation with laboratories in Europe working in the same field and equipped with particular kind of an instrument, intensification of the personal, indirect contacts, integration with other institutions and increasing of education level of young researchers. It will be realized by organizing conferences and workshops, exchange of scientists, education of young people, Round Robin" type of experiments and standardization and quantification of surface science techniques."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards a complete spatiotemporal model of viral morphogenesis during HIV maturation' to be submitted under Seventh Framework.

assistant: **Abstract**

Viral morphogenesis, the phenomenon by which viruses reorganize their internal macromolecular structure in space and time across their lifecycle, is a complex process that is not quantitatively understood. HIV maturation, in particular, involves detailed atomistic processes such as protein-ligand recognition and cleavage that triggers large-scale macromolecular spatiotemporal rearrangement such as capsid self-assembly and RNA-modulated nucleocapsid condensation leading to infectious virus particles (virions) in a sequence of morphological changes that need to be carefully timed. Many antiretroviral inhibitors have been developed to stop maturation but their efficacy has been undermined by the emergence of drug resistant mutations. Furthermore, the effect of such inhibitors on the internal spatiotemporal viral dynamics is unknown.  In order to quantitatively understand the determinants of maturation, inhibition and mutational resistance it is vital to construct a complete physics-based model of the maturation process.   This requires detailed understanding of how all the relevant viral molecular constituents interact with each other at the atomistic level, how this is affected by drug interactions and mutations in proteins and how this carries over to the large-scale cleavage and self-assembly process.  This project aims at deriving a multi-scale computer model of HIV maturation, integrating thermodynamic and kinetic binding data from massively parallel detailed molecular dynamics simulations of viral protein-protein and protein-drug interactions with particle-based reaction diffusion kinetics simulations describing the internal processing and remodeling in an entire virion explicitly in space and time.  We will also investigate what happens if the morphological sequence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European study of clinical, health economic and quality of life outcomes in Haemophilia treatment' to be submitted under Fifth Framework.

assistant: **Abstract**

This study has been designed to evaluate the quality of haemophilia care in Europe to describe the Sol of European haemophiliacs and to estimate the costs needed to attain these levels of quality of life. About 2040 Patients will be recruited con-seductively from haemophilia comprehensive care centres from 22 Countries. The Study will consist of a Sol Study, Cost-of-Illness-, Cost-Effectiveness- and Cost-Utility-Analysis to perform total costs due to haemophilia, to compare alternative treatments and to determine patient's preferences. Haemophiliac patients from 4 years on will be stratified according to following characteristics: severity of haemophilia, presence of inhibitors, treatment schemes. Clinical and health economic data will be assessed at baseline and prospectively over a 6-month follow-up period. In addition the patients fill in a diary during the follow-up period.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Open Source Medical Image Analysis' (OSMIA), addressing dissemination and exploitation.

assistant: **Impact**

Medical image analysis is an established research field as well as a multi-billion dollar industry. However, the lack of a shared software environment within which research is performed limits the reuse of algorithms by other groups, minimises the achievement of long-term objectives and inhibits the uptake of techniques by commercial organisations. In this proposal we intend to trial TINA, a proven image analysis research environment, as an open source medical image analysis system. The consortium will implement and validate a distribution and contribution framework around the software and establish a user community. We will develop and trial an open software interface system to enable commercial organisations to rapidly assess the algorithms available. We will also establish a license framework enabling both the free exchange of research ideas under a public license as well as providing conditions for commercial exploitation.Objectives:- Establish OSMIA as the environment of choice for medical image analysis research building on an existing, proven technology;- Establish a developer community to support and encourage the adoption of OSMIA;- Validate and demonstrate the benefits of using OSMIA in research, ensuring the co-operative sharing of algorithmic ideas;- Specify and introduce a software interface enabling OSMIA executables to be driven from third party commercial products;- Validate and demonstrate this interface as a means of enabling commercial organisations to rapidly evaluate and assess research techniques for exploitation and provide clinical end users with access to state-of-the-art research algorithms;- Disseminate and promote the use of OSMIA at relevant exhibitions and conferences.Work description:In order to achieve a stable, supported open source rele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An Anti-Gravity Active Device for Exoskeletons to Reduce the Impact of Work-Related Musculoskeletal Disorders in the Logistics, Retailing and Manufacturing Sectors.' (2021-2027) under Horizon Europe.

assistant: **Objectives**

We introduce a disruptive, patented motion technology for exoskeletons: AGADE. It relies on a hybrid (active+passive) proprietary actuation system designed to reduce by 10 times electric consumption (compared to common electric motors) and, proportionally, batteries and motors’ weight. AGADE aims at erasing work-related muscular disorders through AGADEXO, the first exoskeleton to combine lightness, comfort and low environmental impact with smart compensation of physical fatigue at work. It is conceived of as a modular product (shoulder, low-back and full-body modules) in order to increase customisation and maximise market coverage and penetration in different sectors, such as logistics, retailing and manufacturing. Our innovation disrupts the market by bringing to it high-tech devices so far impossible to commercialise. The innovative wearable robotic system of AGADEXO does not substitute the individual, but it empowers physical abilities, improves efficiency and satisfaction at work.


**Keywords:** Engineering and technology,Electrical and Electronic Engineering,Exoskeleton ,Collaborative Robotics,Robotics,Health Monitoring,Productivity Monitoring,Low Environmental Impact,Health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'IP1 Traction TD1 and Brakes TD5 – Phase 1' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The PINTA Project (IP1 Traction TD1 and Brakes TD5 – Phase 1) will address the two key topics highlighted in the first Shift2Rail Call topic S2R-CFM-IP1-01-2016 – Development of concepts towards the next generation of traction systems and management of wheel/rail adhesion, namely Traction and Adhesion Management.Traction subproject will focus on the improvement of seven technical and economical performances of the Traction system that have been agreed and defined in Roll2Rail. These performances have to be improved on five different train applications having different constraints, needs and specificities, from tramway to HST, including metro, sub-urban, regional trains. In particular, Traction sub-project will address the following:1)      Line capacity increase through weight, volume and noise  savings of Traction equipment.2)      Operational reliability increase via higher reliability/availability.3)      Railway system LCC reductionAs far as Adhesion management is concerned, the work will lead to the achievement of a number of important objectives linked to Brakes, such as·         Improvement of braking degradation limit in poor adhesion condition·         Management of all adhesion conditions in a way that brake distances are optimized·         Improvement of the overall train safety, which relies substantially on the management of the wheel/rail contact·         Reduction of wheel Life-Cycle-Costs (LCCs) through optimized wheel/rail contact in brakingThe activities should contribute in formulating new performance specifications for Adhesion Recovery Systems. Moreover, improved requirements for Wheel Slide Protection test procedures should be developed, followed by new specifications for Automatic Test benches.


**Keywords:** SiC Traction development, driven inde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Femtosecond laser writing for photonic quantum processors' (FUTURE) targeting Horizon Europe.

assistant: **Abstract**

Ephos is a photonic quantum computing company. Our objective is to build the key element of the infrastructure to power quantum computing: photonic chips. Ephos has a unique asset to reach this goal: it is the only photonic quantum start-up in the world with in-house chip manufacturing capabilities. We build our glass-based photonic quantum processors using a femtosecond laser writing (FLW) process developed by our founding team. Our fabrication process, with respect to those of our competitors, is faster, has lower-cost, higher flexibility, and is capable of working with 3D structures. The resulting chips have low interface losses, which makes them the ideal building blocks of the modular architectures that are the leading contender to deliver scalable quantum computation.The aim of the current project is to support Ephos in establishing the world’s most advanced FLW facility for the production of quantum photonic chips. Over the course of this project, we will build the largest programmable quantum photonic processor in the market. This project will enable the development of more powerful and efficient quantum computing technologies that have the potential to revolutionize various industries. The lower-cost and higher flexibility of Ephos' fabrication process could potentially make quantum computing more accessible for a wider range of organizations and researchers.


**Keywords:** Quantum computing,  quantum technology,  quantum photonic processors,  femtosecond laser writing