RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'From photoreceptors to perception: linking visual pigment biophysics to the speed of vision.'.

assistant: **Innovation**

Vision operates across a billion-fold range of light intensities from a moonless night to a sunny beach. One mechanism contributing to this outstanding performance is the division of labor between two types of light-sensitive receptor cells, rods and cones. In dim light, vision is mediated by slow but highly sensitive rods. In brighter light, cones mediate vision with fast signal kinetics but lower sensitivity. It has been hypothesized that this division of labor corresponds to a fundamental tradeoff between sensitivity and speed common to any (man-made or biological) sensory system. However, the precise nature of this trade-off has remained unresolved, partly because changes in light levels involve fundamental changes in the neural circuits that read out and process rod and cone signals. This research plan proposes to resolve the trade-off between sensitivity and speed end-to-end from photoreceptor signal kinetics to retinal output and to visually-guided behavior with the resolution of single amino acid mutations.To address this ambitious goal, I will contribute my expertise in cone physiology and a battery of genetically modified mice in which single amino acid mutagenesis speeds-up or slows-down cone responses. The Ala-Laurila laboratory will provide the expertise and infrastructure required to causally link opsin biophysics to photoreceptor signaling, photoreceptor signaling to neural processing by the retina, and neural processing to mouse behavior and human perception. This combination of technologies and expertise is unique. As the grandson of Holocaust survivors, this proposal will enable my dream of returning to Europe to take on my first academic faculty job. Professionally, it will empower me to bridge the skills acquired during my Ph.D. to an integrative app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Photoactivatable Drug Releasing Implants'.

assistant: **Concept**

This proposal introduces a next-generation platform for next generation optimally personalised drug therapy: on-demand drug releasing implants triggered and controlled by blue/UV light. The technology is based on novel light generation pathways and a light-sensitive nanocellulose drug reservoir.A formidable physiological barrier for light-triggered drug release has been the inability to use high-energy blue/UV light as the triggering signal. This is because the penetration depth of light drops to from a few cm to under 100 micrometers when moving from near-infrared to UV light, making deeper targets within tissues accessible only to red light. However, red light, with its intrinsically lower energy, has limited value in photochemical reactions because the photocleavage of covalent bonds typically requires UV-light. This is why many groups are looking at e.g. red-to-blue photon upconversion strategies. The major objective in PADRE is to circumvent the issue of unavailable blue light in implants through local light generation. Having access to light with higher energy will enable a much wider chemical toolbox, including photocleavable linkers. I will use blue/UV light to trigger and precisely control drug release. The approach creates an unconventional way to modulate the release profiles without unwanted drug leakage. The light will be generated through either 1) photon upconversion, or 2) integrated light sources. With the first approach, I will pioneer efficient red-to-blue/UV triplet-triplet annihilation upconversion in a hydrogel environment, while in the second approach I will generate light by a co-implanted light source. Both approaches are feasible according to my preliminary results on efficient triplet-triplet annihilation upconversion and photoresponsive lipos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Pharmacokinetic & Pharmacodynamic Drug Information and Dosage Adjustment System' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Objectives - Not only every patient is different, but also every drug. Drug dosage must be individualised and adjusted to the patient' s organ function (e.g, age, kidney) and severity of disease (e.g. outpatient, or intensive care).DESCRIPTION OF WORKConsortium - The original consortium has 4 small and medium sized enterprises (DatMO, IGESber, MediHeer, ZuPvien) and 4 research and technology developers (NEPharm, MWPharm, GPNott, HospOer). The basic components are available, namely the pharmacokinet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Human - Centric Indoor Climate for Healthcare Facilities'.

assistant: **Objectives**

Over 4 million hospital patients acquire a healthcare-associated infection (HAI) in the EU each year. Moreover, the global crisis of antimicrobial resistance means that HAI is posing an increasing cost and risk of mortality. There is clear evidence that airflow controls the dispersion and exposure to airborne pathogens and determines the contamination of critical surfaces in the human-centric climate (HCC), which is defined as the microenvironment which surrounds and is close to a human body. This points to a significant need for innovation in healthcare indoor environments to tackle the challenge of infectioncontrol, while improving thermal comfort and energy efficiency in hospitals. To achieve this, we must both advance the fundamental understanding of how people are exposed to airborne pathogens and develop new tools and techniques to enable effective design and operation of healthcare environments. Specifically, there is a need to understand better the local influence of airflows on particles in HCC; quantify the transient behaviour of airflows and contaminants due to healthcare activities like surgery; develop methods for optimising and adapting ventilation systems to control for risks in different environments like operation rooms and isolation rooms; and develop tools to enable real-time interaction with environments during design and operational phases. Bringing together 8 leading academic teams, 4 healthcare facilities and 8 HVAC industry partners, the HumanIC network aims to build a new approach to hospital environmental design through the concept of HCC and the training of 15 Early Career Stage Researchers to address these needs. HumanIC will create and disseminate fundamental and applied science to improve the knowledge base and innovate new technologies for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrating research in molecular life sciences at the University of Zagreb', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

INTEGRA-LIFE will functionally integrate and reinforce the most promising research groups in glycoproteomics, epigenetics, genetic engineering, biochemistry and bioinformatics through collaboration with 13 eminent European partnering organisations. By fostering collaboration between different Faculties and scientists working in different disciplines we will promote multidisciplinary research that can enable significant progress from current state of the art. The procurement of new generation of instruments for the analysis of DNA (next generation sequencer), glycans (mass spectrometer) and macromolecular interactions (thermophoresis), as well as advanced computer cluster for data analysis will enable our participating researchers.Our main strength is the already demonstrated excellence of our participating researchers in several complementary areas of molecular life sciences (glycoproteomics, epigenetics, genetic engineering, biochemistry and bioinformatics). Significant investments in both equipment and human resources in the past years enabled creation of a considerable research potential which will be further increased. The proposed integration of research efforts of 24 participating principal investigators into four strategic research priorities creates the opportunity to form a respectable critical mass of researchers and infrastructural capacity which would enable the most ambitious interdisciplinary research projects. Specific opportunity for rapid progress exists in the field of glycome analysis where we are currently one of the leading laboratories in the world. Through the proposed integration of researchers working in glycoproteomics, bioinformatics and epigenetics we have the chance to form interdisciplinary team with unique set of competences and become wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Epithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body'.

assistant: **Objectives**

Epithelia are sheets of interconnected cells that cover the surfaces of our body and internal organs. They form physical barriers that protect our body from external insults and control the exchange of materials with the outside. To perform these functions, epithelial cells establish a specialized apical (top) exchange surface that faces the exterior. Defects in epithelial functioning contribute to many diseases, such as cystic kidney diseases, inflammatory bowel disease, and susceptibility to infection. Moreover, loss of epithelial organization is a hallmark of invasive tumours.SurfEx will tackle two urgent interlinked problems that hamper progress in combatting epithelial diseases. 1) the need for highly-skilled scientists who can bridge basic research in small model organisms and cell culture with translational research using advanced 3D culture models that mimic the organization and physiology of human epithelia, and 2) the need to improve our understanding how the apical exchange surface is formed and functions in health and disease.SurfEx brings together academic and private partners from 8 European countries to establish a multidisciplinary, intersectoral training and research programme that will study how epithelial cells form a functional apical exchange surface. SurfEx unites fields ranging from genetics to materials science, microfabrication, and advanced 3D cell culture techniques. This provides an opportunity to train doctoral candidates in a unique combination of experimental approaches and methods, including breakthrough organoid and organ-on-chip technologies.Tight collaboration with non-academic partners will strengthen the technological base of different projects and provides the fellows with insights into the translation potential of the studies and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Wave Energy Generators for Marine Buoys and Aquaculture Fish Farms' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the last decade, over 700€ million have been invested by private companies in the development of marine energy. Some EU-Member countries such as the UK, France, Ireland, Spain, Denmark and Portugal are heavily investing in this sector. However, it is still a raw sector with high risks and some companies are shutting down or reducing their projects due to the operating and maintenance costs of these plants.eForcis and BeForcis are wave energy generators and represent the next stage of technology to harvest wave energy for the economic activity at sea, especially offshore. By focusing on low potential energy and the reduction of energy costs, our product will reduce carbon energy consumption and contribute to more efficient and competitive maritime economic activities. At SMALLE Technologies, SL, we are a high-tech company developing innovative energy harvesting devices. Our flagship product is the eForcis wave power generator, which is able to capture energy (between 2-10 Ah/day) from the sea waves. Our mission is to develop new methods of responsibly using renewable and sustainable energy sources to power off-grid devices. We offer reliable, high-quality and cost-effective products supported by extensive R&D. We want to reduce the carbon footprint of electricity production having a positive impact on the environment. The next steps in our company strategy are to increase the TRL6 of our eForcis equipment to reach a marketable product closely working with key clients in the buoy sectors, and to finalise and test the BeForcis technology (optimization of eForcis technology incorporating a buoy) to serve the wide aquaculture market. This determines the objectives of our Phase 2 Project.The proposed project intends to develop state-of-the-art small size devices that will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The basic principles of polyploidy in plants and animals'.

assistant: **Concept**

Many eukaryotes have more than two sets of chromosomes due to whole-genome duplication (WGD) and are called polyploids. WGDs explain many cases of speciation bursts and evolutionary inventions. Some evidence suggests an adaptive advantage of polyploids: the origins of many ancient WGDs correspond to the times of extreme climate change, and contemporary polyploids often occupy harsher environments compared to their ancestors. However, most new polyploids are not as lucky and rarely survive. To explain the cause, predict and manipulate this process, we need to understand the basic principles of polyploidy: (1) how it is triggered, (2) what enables the initial survival of newly formed polyploids, and (3) how they stabilize a population and become successful. My program will comprehensively cover all these aspects, from the functional and genetic levels to the evolutionary forces driving the entire process. I propose a cross-disciplinary approach to identify common polyploidy principles in plant and animal diploid-tetraploid species complexes: Arabidopsis lyrata, widespread plant in Northern Hemisphere, and Neobatrachus, burrowing frogs living in the Australian desert. The approach combines classic genetics with the latest genomics technologies and population genetics analysis of natural herbarium and museum collections across broad geographies. I will (1) expose genetic and environmental predispositions to polyploidy formation by mapping natural variation of the unreduced gametes rates; (2) reveal mechanics and genetics stabilizing meiosis in polyploids, comparing recombination and selection across ploidies; (3) uncover polyploid populations recovery processes after bottlenecks accompanying their origin by reconstructing introgression patterns. Deciphering the mechanisms l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Matter-wave circuits of multi-component ultracold atomic systems' under Horizon Europe.

assistant: **Concept**

The proposed research project is in the field of atomtronics, a research area that capitalizes on the versatility and customizability of ultracold atoms trapped in magneto-optical traps to realize quantum circuits of guided matter-waves in various architectures. Specifically, I rely on a peculiar aspect of atomtronic circuits: the statistical nature of the quantum fluid coursing through them, be it bosons, fermions, or a mixture thereof, which dictates their functionality, leading to radical new circuitry. Focusing on atomtronic circuits whose quantum fluid is composed of strongly interacting multi-component fermionic and bosonic atoms,  I will provide prototypes for unique and innovative hardware for quantum technologies geared towards quantum sensing, extending the scope of cold atom quantum simulators in basic science. My efforts will simultaneously span across three domains that Europe's Quantum Flagship and its several extensions outlined: sensing, simulation, and basic science. An attractive feature of atomtronics is the expectation that final applications exploiting its devices and its strategic sub-fields are close to fruition, corroborated by the great efforts and resources of important 'world nerve-centres' for quantum technologies (NIST (USA), CQT-NUS (Singapore) and LENS (Italy)). After an intensive study of atomtronic circuits operating with bosonic fluids, recent experiments have set in motion the next chapter in atomtronics to explore the potential of multi-component fermionic matter-waves circuits. Building on the foundation of my earlier works on this topic, the ideas outlined in this proposal explore this new direction of atomtronics-enabled quantum technologies revolving around the SU(N) AQUID -- the atomtronic counterpart of the SQUID, which is expec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Disruptive innovation through new tool steels with unique thermo-mechanical performance for material forming applications' in the context of a Horizon 2020 call.

assistant: **Objectives**

Since the mid 80’s, vehicle weights have increased despite the importance of vehicle weight on driving dynamics, agility, and fuel consumption. Consumers have been more interested in larger, cheaper cars rather than weight reduction. The trend of ever-increasing weight for cars has been curtailed in recent years, predominantly motivated by CO2 emissions targets and correlated penalties, through the increased use of plastics and advanced steel alloys. It has been demonstrated that use of these lighter materials could reduce car weights by 35% and life cycle emissions by 70%, however their application has been limited due to limitations of the tools that are used to form them. The current tools are not fit for these new purposes as they do not have the thermal conductivity (TC) and material properties (MP i.e. strength) to effectively use these new materials and forming processes. The formation of large, lightweight pieces using advanced light alloys (eg. Aluminium and Magnesium), ultra-high-strength steels (strength >2000 MPa,) and advanced plastics (thermosetting and composite polymers) require tools made from tool steels that have both high TC and high MP. In an early phase, ROVALMA have successfully developed and verified a prototype tool steel, FASTEEL, that offers high TC and MP, while allowing tools to be manufactured using conventional tool manufacturing processes. These improvements now mean that FASTEEL tools can be applied across many applications, allowing the production of large, lightweight pieces made from advanced materials.In this SME phase 2 project FASTEEL will be demonstrated and evaluated by several market leading clients in the automobile components sector, in 8 key market applications, to assess FASTEEL’s performance at producing high strength, larg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Artificial intelligence for early speech production' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Babbling is a critical milestone of infant speech development. In only 12 months, infants explore how to move their mouth, tongue, and vocal cords to produce increasingly complex sounds before eventually producing their first words. Investigating early vocal development in both typical and atypical infant populations requires meticulous efforts involving the time-consuming and labor-intensive process of manually transcribing children’s linguistic productions. The present action, at the crossroads between speech processing, machine learning, and language acquisition, proposes to 1) build an open-source automatic universal phone recognizer for infant vocalizations to accelerate language acquisition research; 2) design an innovative measure to assess when early vocalizations reflect the infant’s ambient language(s); and 3) apply the developed methodology to the study of typical and atypical infant populations. By combining large-scale multilingual corpora and state-of-the-art automatic speech processing tools, our first objective is to endow researchers with a novel tool to advance our understanding of infants’ early vocal development. Our second objective is to shed new light on the simple yet controversial question: When do infants start exhibiting distinct babbling patterns across different languages? Beyond its theoretical implications, our proposal holds clinical significance as we will apply the developed tools and measures to investigate early vocal markers associated with speech disorders, constituting our third objective.