RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Systolic and diastolic estimates in geometry' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The project is devoted to two classes of metric invariants of Riemannian and contact manifolds: systoles and diastoles. Riemannian systoles are shortest non-contractible curves (and higher-dimensional cycles) on manifolds and other spaces. Diastoles measure longest curves in an optimal slicing of a manifold into a family of curves (or cycles). Symplectic/contact systoles measure the least action on closed characteristics (integral curves of the Reeb flow). The goals of the project are to extend and complement the results of M. Gromov, M. Freedman, C. Viterbo, and others, by relating all these invariants to the volumes of the corresponding spaces and other metric quantities. A key tool for investigating the systolic freedom (measured as the behavior of several systoles compared to the volume) is its connections with quantum error correction codes, which are a promising rich source of spaces of great systolic freedom. The diastolic geometry, which is the study of waists of slicings/foliations/sweepouts via the methods of geometric analysis, has applications to the open Buser pants decomposition problem, as well as connections with persistence and dimensionality reduction in manifold learning. The symplectic isosystolic/isodiastolic conjecture of Viterbo, which will be studied via extensions of billiard approach, has exciting implications in convexity, namely the longstanding Mahler conjecture on the volume product. My experience in waist and width estimates, combined with the expertise of Prof. Hugo Parlier in systolic geometry and Buser's problem, will help me to carry out this project at the University of Luxembourg. The secondment at Freie Universität Berlin in the quantum group of Prof. Jens Eisert will help me to bring closer the systolic and quantum topics of resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Continuation of the international network - non-energy use and co2 emissions (neu-co2)""'.

assistant: **Innovation**

A significant fraction of fossil fuels is consumed as non-energy use, i.e. for the manufacture of synthetic materials and chemical products, e.g. plastics, paints, sol-vents, lubricants and bitumen. In the long run, these products might contribute sub-statically to CO_2 emissions. In Western Europe, non-energy use represents 11-12% of the total amount of fossil fuels for final consumption. In other parts of the world, the manufacture of non-energy products is increasing at a tremendous pace, e.g. in Asia. There is still a lot of uncertainty and lack of knowledge regarding the CO_2 emissions from non-energy use. The NEU-CO_2 network is already working on this issue (current funding period 1.1.1999 - 31.1.2000). In this proposal the continua-ton of the network is applied for. The NEU-CO_2 network is developing a tool, the NEAT model. Together with the empirical insight gained by the network, this model will provide the foundation for developing recommendations to the IPCC and the FCCC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New Generation of orthopaedic Biomaterials' under Seventh Framework.

assistant: **Concept**

Biomaterials industry and especially the orthopaedics sector represent a large market globally with growth rates of 7-15%. Unfortunately current biomaterials are not optimal and cause pain and distress to a large number of patients. Particularly their life cycle is very small compared to the average starting age of musculoskeletal disorders. The raw materials used can cause neurological problems as Alzheimer disease due to metal ions released in the body and the stress shielding effect can lead to bone atrophy. Also the structural and mechanical properties of biomaterials used in implants are not optimal, chemical inhomogeneity and large distribution of porous dimensions are common factors in production process.  There is a clear need for innovation in biomaterials production in terms of biocompatibility, mechanical, and surface properties. NewBioGen introduces a new biomaterial production process that will solve the current problems and provide a new generation of orthopaedic bio-implants. Beta titanium alloys, containing fully biocompatible elements, will be optimised and validated as raw materials for the biomaterial production. The new production process will be using powder metallurgy technology. Use of powder metallurgy for bio-implants production will allow increased control of the final characteristics and properties of the product. It is expected to significantly reduce the chemical and porous inhomogeneties - a source of stress and cause of mechanical implant failure.  The next step in our novel approach is the application of ZrO2/Zr coating on the implant using Laser Engineered Net Shape techniques to give better wear resistance and lower the possibility of interfacial separation under repeated loading condition. NewBioGen is taking a new route to establish m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The structural and dynamical ensemble of an amyloidogenic intermediate' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Proteins and peptides have a generic tendency to convert from their soluble states into well-organized aggregates characterized by a fibrillar morphology and an extended cross-beta structure. Such transitions can give rise to over 40 pathological conditions ranging from neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, polyQ disease, to systemic amyloidoses, including light chain amyloidosis and hemodyalisis-related amyloidosis. Unveiling the origins of amyloid disorders is one of the top scientific challenges. It is clear that a better understanding of the molecular mechanisms of protein and peptide aggregation into amyloid fibrils will allow optimal therapeutic strategies and the development of better drugs to combat these disorders. Nevertheless, despite the huge efforts of the scientific community, the molecular determinants underlying these processes are still largely obscure. The aim of the present project is to determine, at an atomic level, the structural and dynamical ensemble of the amyloidogenic intermediate of a novel Acilphosphatase, the AcPDro2. This protein represents a prototype of for studying the aggregation via native-like conditions, a major aggregation pathway in vivo. The project will be performed in the lab of prof. C.M. Dobson (University of Cambridge) and will be based on a multidisciplinary approach of experiments (basically solution-NMR) and molecular simulations to characterize the conformational ensembles adopted along the AcPDro2 aggregation pathway. This study will provide the atomic description of the molecular determinants of AcPDro2 aggregation into amyloid structures. Moreover, an appealing part of the project will focus on the mode of actions of a small ligand, the phosphate, which is able to inhibit the A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development and application of time resolved resonance energy transfer (tr-FRET) based methods for investigation of the earliest stages of protein folding and misfolding' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The question of how the sequence of amino acids dictates the final fold of globular proteins remains one of the fundamental riddles of structural biology. The objective of the present research plan is to identify sequence elements that contribute key local and non-local interactions that are effective during the initial steps of the folding process.A series of experiments are proposed to identify critical residues that form such effective interactions. Initial phases of the misfolding of globular and natively unfolded proteins will be explored in order to explain these processes and ultimately to control negative consequences of misfolding, e.g. formation of amyloid plaques. An interdisciplinary approach aimed primarily at structural characterization of the rapidly changing ensembles of partially folded protein molecules will be adopted. A number of methods will be applied, in particular time resolved FRET, -FRET detected FCS; FRET detected fast-kinetic methods, (a novel high pressure jump and micromixing based double kinetics experiments); protein engineering and computational methods.The hypothesis is that few very effective non-local contacts can direct the backbone into a native like fold at the early phase of the folding transition. This hypothesis will be explored to identify the essential key interactions and specific clusters of residues that contribute to those interactions. The response of the ensembles of conformers to changes of pressure; temperature; solvent composition and to the insertion of structure perturbation mutations will be monitored. Computational and bioinformatics methods will be applied in an attempt to generalize the experimental results.In order to achieve these goals the host research group will bring in- methods for construction of a press
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'When and how to be creative? Neuro-cognitive investigation of creative metacognition.' (CreativeMetacognitio) targeting Horizon 2020.

assistant: **Abstract**

Creativity, defined as the ability to generate novel and effective ideas, elevates cultural progress and as a basis for innovation is crucial for enhancing economic competitiveness and strengthening society. On personal level, creativity increases well-being, positive affect, flourishing, and plays an essential role in learning. Creative behavior is an agentic decision and it also depends on the conviction about one’s own abilities to manage the creativity challenge and on how much creativity is valued by that person and surroundings. The constellation of beliefs that determine a person’s engagement and performance on creative endeavors called creative self-beliefs. It was proved that these self-beliefs play an intermediary role between creative abilities and creative action behavior So far, of the all components of creative self-beliefs we know the least about creative metacognition, which is defined as a combination of creative self-knowledge (knowing one’s own creative strengths and limitations) and contextual knowledge (knowing when, where, how, and why to be creative). Even though several researchers and theorists pointed out that creative metacognition plays an essential role in the process of creative potential realization, there is still very little research on this topic.Based on available theories and research results, we propose a two-stage research program to extend knowledge about individual differences in creative metacognition (CMC) considering 1) CMC accuracy and 2) CMC regulation facets from a behavioral and neuroscientific perspective. The Maria Skłodowska Fellowship participation will facilitate successful execution of the project, but also target areas, in which I require additional skill development to prepare and position me for a career as an inde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Machine learning for computational science:statistical and formal modelling of biological systems'.

assistant: **Innovation**

Computational modelling is changing the face of science. Many complex systems can be understood as embodied computational systems performing distributed computations on a massive scale. Biology is the discipline where these ideas find their most natural application: cells can be viewed as input/ output devices, with proteins and organelles behaving as finite state machines performing distributed computations inside the cell. This led to the influential framework of cell as computation, and the successful deployment of formal verification and analysis on models of biological systems.This paradigm shift in our understanding of biology has been possible due to the increasingly quantitative experimental techniques being developed in experimental biology. Formal modelling techniques, however, do not have mechanisms to directly include the information obtained from experimental observations in a statistically consistent way. This difficulty in relating the experimental and theoretical developments in biology is a central problem: without incorporating observations, it is extremely difficult to obtain reliable parametrisations of models. More importantly, it is impossible to assess the confidence of model predictions. This means that the central scientific task of falsifying hypotheses cannot be performed in a statistically meaningful way, and that it is very difficult to employ model predictions to rationally plan novel experiments.In this project we will build and develop machine learning tools for continuous time stochastic processes to obtain a principled treatment of the uncertainty at every step of the modelling pipeline. We will use and extend probabilistic programming languages to fully automate the inference tasks, and link to advanced modelling languages to allow for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bottom-up Resolution of Functional Enantiomers from Self-Organised Monolayers' in the context of a Seventh Framework call.

assistant: **Objectives**

The high throughput identification of resolution systems for industrially important chiral chemicals will be approached using the bottom-up hierarchichal assembly from self-organised chirally nanostructured surfaces and the “Dutch resolution” family method to isolation of enantiomers.  Molecular modelling, surface science, supramolecular chemistry and the critically important resolving library design will be used in synergy to develop systems which separate enantiomers and which can be patterned and miniaturised. The preparation of chiral surfaces and the knowledge of chiral discrimination phenomena at the nanoscale will be exploited to use them to template the formation of diastereomers, which in turn will lead to the formation of crystals (whose composition will be determined) containing pure enantiomers. The project’s end goal is a rapid method for the identification of resolving systems for optically active compounds, and would constitute a leap forward for the area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Missions: Engagement and Education for Tomorrow' to be submitted under Horizon Europe.

assistant: **Abstract**

MEET - Missions: Engagement and Education for Tomorrow - is the proposed “European Researchers Night” event and “Researcher at School” programme in Milano and Lombardy (Italy), for the 2024 and 2025 editions of the Night, and for the school years 2024/25 and (partly) 2025/26. Firmly rooted on a mission-oriented approach and bringing together top R&I and institutional players in Milano area, MEET has the challenging goal to reduce the gap between research and citizens, increasing their sense of trust in science and fostering a participatory approach in which everyone feels involved and benefits from the opportunities offered by scientific citizenship, in an inclusive way. The project combines a captivating science festival format for the Nights, targeting the public at large, with a two-years structured programme devoted specifically to the schools. During the Nights, science-based entertainment initiatives, interactive exhibitions, talks and participated moments, such as real-life workshops and science matches, will involve citizens in a journey to discover that R&I could and should be acted and enjoyed by everybody. At school, MEET brings public engagement initiatives and innovative education approaches, with researchers first-hand experimenting citizen science with pupils, engaging them preferably but not exclusively on the themes of the EU Missions. The acquisition and recognition by the research community of the role of citizen science as a research methodology will become a lever for an institutional change, supported by MEET.  Overall, MEET will permanently work to stimulate proactive scientific citizenship to engage society and schools, through different tools and methods, in reflecting on grand societal challenges and on how science could shape culture and futur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Poplar root exudates response to multi-nutrients stress'.

assistant: **Objectives**

In the face of global changes, agroecosystem productivity is essential both for CO2 fixation and feeding the increasing population. However, plant growth is frequently limited by nutrient availability and in the environment, plants are more often exposed to multiple than single nutrient deficiencies. Plant responses to single nutrient deficiencies have been widely studied while the combined effect of different nutrient deficiencies has been scarcely investigated, particularly for tree species. Root exudates comprise a complex mixture of organic compounds, directly involved in the biogeochemical cycles of nutrients in soils, it can be assumed that their quantity and quality are affected by combined nutrient deficiencies in a different way than under a single one. Thus, this proposal aims to profile Poplar (a fast-growing tree) root exudates under single and combined deficiencies, mainly focusing on: (1) N for macronutrient deficiency as the most often limiting nutrient and on Fe, Zn, and Mn as micronutrients because of their crucial role in photosynthesis, (2) experiments on mineral deficient calcareous soils close to agronomical situations and (3) testing the potential of Poplar root exudates to alleviate nutrient deficiencies in sensitive species such as fruit trees growing on  calcareous soils. The applicant has a very strong background in soil chemistry and plant nutrition acquired during her MSc and Ph.D., which together with the experience and facilities of the host and the international supervisory team will lead to the successful completion of this project and the strengthening of the career development of the researcher. The interdisciplinary work involving plant physiology, metabolite profiling, and chemoinformatic tools will lead to (1) improve knowledge about
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developing high-performance recycled carbon fibre reinforced plastics with tailored mechanical, fracture and fatigue properties using state-of-the-art nano-modification technology' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

This project aims to develop high-performance RECYCLED/discontinuous carbon fiber reinforced plastics (d-CFRPs) with tailored mechanical, fracture and fatigue properties using state-of-the-art nano-modification technology. Moreover, a significant side benefit of this research is a further development and validation of a fatigue test method for CFRPs towards standardization. The project involves: (1) formulate and characterize a series of epoxies modified by different nano-additives, i.e. rubber, silica, carbon nanotubes and graphene; (2) produce a series of d-CFPRs based on selected nano-modified epoxies and recycled carbon fibres; (3) characterize the mechanical properties, fracture toughness and fatigue resistance of the d-CFRPs; (4) investigate the fracture mechanisms and quantify the fracture features of d-CFRPs for both quasi-static and fatigue failure to build the correlation between fracture features and energy dissipation; (5) further develop and validate a fatigue test approach for CFRPs towards standardisation, together with other world-leading researchers from ESIS-TC4 (European Structural Integrity Society Technical Committee 4).   Turning CFRP waste into a valuable resource and closing the loop in the CFRP life-cycle is vital for the sustainable use of carbon fibres. The research outcomes of this project (turning CFRP waste into high-performance d-CFRPs) will fit neatly with the big priority of Horizon 2020 Work Programme 2018-2020 in ‘Increased investment in sustainable development and climate related R&I’, and the new ‘From Waste to Resource (VANG)’ programme developed by Dutch government. The successful development of high-performance d-CFRPs will facilitate the recycling of CFRP waste and promote the applications of recycled d-CFRPs, hence to make contr