RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mechanisms of CENP-A Assembly and Propagation at Fission Yeast Centromeres'.

assistant: **Concept**

Centromeres are vital structures on eukaryotic chromosomes that are essential for proper chromosome segregation during cell division. Centromeric DNA is bound by a centromere-speciﬁc variant of histone H3 known as CENP-A that replaces canonical H3 in centromeric chromatin, thus specifying centromere identity. The regulation of CENP-A chromatin assembly, however, remains poorly understood. Here, I propose experiments directed towards understanding how CENP-A chromatin is established and faithfully propagated in the ﬁssion yeast Schizosaccharomyces pombe.In Aim 1, I will adopt biochemical and genetic approaches to identify novel factors that contribute to CENP-A chromatin integrity. I expect to discover proteins that could inﬂuence CENP-A chromatin at several levels, including CENP-A assembly factors & chaperones, chromatin remodelling and histone modifying enzymes. In Aim 2, I propose to systematically characterise the novel factors identiﬁed from Aim 1, in order to assess their exact functions at centromeres. I will also perform experiments that will allow me to classify them into two distinct groups: CENP-A incorporation speciﬁc and CENP-A propagation speciﬁc factors. In Aim 3, I will devise a specialised approach to investigate the features of CENP-A that confer it the unique ability to serve as an epigenetic mark that maintains centromere position and identity.Through the state-of-the-art approaches I propose in this application, I expect to uncover the complex mechanisms that define centromeric chromatin integrity. This research will elevate Europe's reputation in epigenetics and chromatin research, and thus enhance European excellence in the life sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The first wide range flow sensor to unlock microfluidic cell analyses for preclinical studies' (GALILEO).

assistant: **Concept**

There is a critical need to improve the diagnosis, drug discovery and development pipeline to increase the success rate of new therapeutics (as low as 3.4% for cancer drugs) and provide earlier detection and treatment. Microfluidic cell-based assays and analyses are one of the most promising strategies, supported by direct feedback from industry and regulatory agencies. Integrated microscale fluidics adds an extra dimension to in vitro cell cultures and is an enabling technology of single cell analyses and nanotherapies. However, the main limitations with these platforms expressed by our clients from academia and industry are their inability to measure and control flow rate over a wide enough range (100-times too narrow), imprecision and failure to detect sensor drift that leads to experimental error. Our GALILEO flow sensor innovation demonstrates the technical ability to address these pressing requirements for microfluidic cell assays and analyses. This proposal will advance the proof of concept to a viable demonstrator of the technology for beta testing.The timing is ideal for our solution: expressed end user demand is high and legislative bodies have voted to reduce animal testing by 2035. GALILEO has strong competitive advantage in the microfluidic flow sensor market with a SAM of 535 mil EUR/year, increasing with the growth of next-generation sequencing and genomic medicine. Elvesys is an entrepreneur-led microfluidics instrument company with demonstrated success in the development and commercialisation of 15 instruments for microfluidic flow control, and the generation of 10 growing spin-offs in the last 11 years. Our end user feedback and iterative testing approach to innovation puts us in a position of strength to execute an optimal product-market fit, targetin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '4-Deep Brain Reconstruction' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The 4-Deep Brain Reconstruction, 4-DBR consortium aims at generating a brand-new technological approach to regenerate brain affections that occurs in neurological disorders. With 180 million affected people and an economic burden of 798 billion euros/year, Europe needs a radical leap in the future. The complexity of the human brain has condemned every past attempt at regeneration because incomplete technologies did not allow for a full recapitulation of the brain properties and any one of them missing jeopardized the functionality of the whole. There can't be any incremental solution for brain damage, the technology must be all-in. 4-DBR will focus on developing an implantable 4D reconstructed brain able to recapitulate all brain properties: a complex architecture of neuronal cells integrated in a complete blood circuitry, that will be complemented with an integrated opto-stimulator to induce correct specification and integration of neurons. 4-DBR integrates 6 technological leaders from complementary fields who will unite to develop the components of reconstructed-brains: laser-assisted bioprinting of pre-differentiated neurons with their native decellularized brain matrix, extrusion bioprinting of vascular system, in vitro blood-brain-barrier reconstruction and a tissue integrated wireless-controlled stimulating optoelectrical chip. These 4 components will then be combined into a transplantable reconstructed brain that will be tested in a small animal model of Huntington’s disease. While a first prototype will be delivered in 36 months, the vision unifying 4-DBR expands way further. Therefore, the project will put into action a strong dissemination and exploitation plan: horizontally, 4-DBR will ensure the uptake of the generated methods to strengthen Europe’s technolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Revolutionary Nanodrip printing technology for industrial scale manufacturing enabling the next generation of high-end devices  Type of funding scheme: SME Instrument'.

assistant: **Objectives**

The ongoing global trend of miniaturization is driven by the demand for a huge range of high-end devices such as smartphones, automotive connectivity and IoT/AI applications. This is highly dependent on the fabrication of embedded Integrated Circuits on semiconductor wafers & the advanced semiconductor packaging processes that protect ICs while providing connectivity to printed circuit boards & adjacent ICs. The fabrication of redistribution layers (RDL), is particularly challenging and expensive, representing a major challenge in the industry. Current RDL microfabrication technology constitutes multi-process chain (19 steps) and is incredibly capital intensive. Existing technology impacts the environment through vast consumption of energy and water. It provides limited flexibility at the wafer-level, restricting the use of optimised materials to microfabricate and limiting manufacturers ability to produce different packaging designs between production cycle, incurring high-fixed costs or expensive downtimes. NanoDrip is the first printing technology which is applicable to advanced packaging, providing ultra-high-resolution microfabrication suitable for industrial manufacturing in merely 2 step-process. It enables digitality, the capability to produced different designs between production cycles with unprecedented flexibility. It introduces a disruptive paradigm shift in the fabrication of advanced electronics at a crucial time for the European industry, allowing European SMEs & large semiconductor manufacturers to gain competitive advantage as demand grows for next-generation of devices. During the phase 1 project, Scrona will establish a go-to-market strategy and a supply chain and will draft further development plan. During the innovation project, Scrona will optimis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coordinated approacH to the EurOpean effoRt on aUdiovisual Search engines' (CHORUS).

assistant: **Concept**

CHORUS is a Coordination Action which aims at creating the conditions of mutual information and cross fertilisation between the projects that will run under Strategic objective 2.6.3 and beyond the IST initiative. CHORUS workplan includes the set up of a co-ordination and information exchange platform (concertation meetings, newsletter, website) to enhance the interactions and to invoke discussions between the key players of the IST Cluster and thus to stimulate the creation of the European Research Area (ERA).An important task of the project consists of supporting the preparation of an analysis and a roadmap for the realisation of Audiovisual search engines in EU. That activity will need a multi-disciplinary (societal, economic, regulatory and technological) approach and will imply the participation of major Stakeholders of the domain through the creation of a Think-Tank. That structure, to which several representative organisations have already agreed to participate, will contribute to give an industrial relevance to the coordination action and its visions.Interaction and dissemination will be further ensured through the set-up of a perennial conference and dedicated workshops addressing a large community which complement the coordination instruments proposed by CHORUS.The consortium represents established and well-reputed research institutions and consultancies with a broad range of intellectual and technological expertise in the area, both as regards concrete actions and policy development and track records of national, Union-wide, and international cooperation and activity. Those actors have the experience and the network to achieve a wide audience for the efforts under discussion, and possess the experience and authority both as regards research and industrial wei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Developing the PTO of the first MW-level Oscillating Wave Surge Converter'.

assistant: **Innovation**

The MegaRoller project will develop and demonstrate a Power Take-Off (PTO) for wave energy converters. The PTO is developed in conjunction with oscillating wave surge converters (OWSCs), a class of wave power technology that uses bottom-hinged plates oscillating in pitch following the surge movement of the water particles in the nearshore zone (10m-25m water depth). The development and demonstration of the PTO for a 1MW OWSC device is based on multiple hardware innovations (modular design, twin drive trains, intelligent cylinders, standardized central power unit and novel accumulator arrangement) and software innovations (wave-by-wave damping control, advanced efficiency control, energy storage control, power smoothing and prediction). The project will therefore generate extensive know-how in the area of PTO design and PTO control systems, with the aim to decrease the LCOE of next generation OWSC devices below €150/MWh. The methodologies used in the project (such as wave-by-wave damping control and prediction, standardized power units) will be applicable to many other Wave Energy Converter types and generate new standards (algorithms) for PTO control, thus benefiting the broader ocean energy community. The full-scale PTO will be validated in a PTO test rig available at AW-Energy in Finland, a facility allowing the consortium to create power matrices for the wave conditions of different sites, fine-tune the PTO control algorithms, certify the operation of the PTO and ensure that the produced electricity conforms to the various grid codes of different market areas. In the short term, the developments will increase performance (power conversion from 70 to 88%), increase reliability (lifetime x2, service intervals x2, O&M costs -75%), decrease costs (power density x2.8) and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Local Food supply communicated through a transactional searchable MAP based APPlication (FoodMAPP) to promote short food supply chains; food security; business development and reduction in food waste.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Interconnected challenges of climate change, food supply resilience, food miles, food waste and supporting the next generation of producers and operators with a fair income are all highlighted in the EU Strategic Plan. Foundational redesign of our food supply systems is required, with urgency, to address these challenges and accelerate the twin green and digital transitions.Current industrial scale food producers and processors lead to complex supply chains that are disconnected from local communities and a rebalancing toward more local supply is sought to address these challenges. The objective of FoodMAPP is to lead this transformation of food supply by enabling and promoting transparent local provision from local producers, including small scale family farmers, and processors direct to consumers. FoodMAPP will, for the first time, gather extensive market intelligence from all stakeholders including producers, processors, consumers to understand market demand and preferences towards localised food supply transparency. This underpinning research will inform the development of a dynamic searchable map-based platform enabling local providers to supply and sell produce directly to consumers. Food supply from small scale family farmers, local processors and food service operators will be included. The platform will be trialled with local communities and refined prior to full exploitation and comprehensive dissemination to stakeholders and policy makers.The project brings together a consortium of leading experts in the fields of agri-food economics, technology development, food supply chains, psychology and consumer behaviour. Four academic beneficiaries will be partnered with four industry partners with extensive networks and experience in food supply systems. Exchange bet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Supporting the implementation of FP6 research activities related to waste water use and recycling by using new generation greenhouse systems, adapted to the requirements of the MED partner countries' (CYCLER-SUPPORT).

assistant: **Innovation**

Mediterranean Countries struggle with serious water problems like rising water competition between agriculture, households and industry, but limited and/or salt-affected water resources, irregular rainfall, escalating dehydration of landscape; and with inefficient wastewater treatment systems leading to pollution of surface- and groundwater.There are different research activities accomplished under the FP5/FP6, showing very promising approaches to re-use and to recycle conventional and unconventional irrigation water in greenhouses, with the potential to up-grade and to re-use wastewater as non-conventional water resources, to extremely reduce the pressure on freshwater resources and the pollution of surface- and groundwater, to make greenhouse cultivation almost independent from drought and irregular rainfall, to add value to otherwise unproductive land, and to improve the water consumption efficiency and effectiveness in agriculture.However, these research activities have not been implemented in the Mediterranean Partner Countries so far. Main reasons are too high costs for the special water cycling greenhouse architecture and technology, insufficient studies about MPC's wastewater collection systems and about the socio-economical benefits and risks to upgrade wastewater by greenhouse irrigation, and insufficient studies about the market value of useful crops which can be used in combination with greenhouse internal wastewater treatment.In this context, the objectives of this project are to collect the missing information by accomplishing a detailed CYCLER-SUPPORT study, to disseminate the existing know-how of accomplished research activities and the completed study results mainly by a final CYCLER-SUPPORT-WORKSHOP, to give a clear view over further needed research ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Donor T Cells for Immune Control' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Patients with high-risk hematological tumors can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). However, the main causes of failure of HSCT are infections, tumor relapse and over-shooting immune responses of the donor T cells to healthy cells and tissues of the patient or graft-versus host disease (GvHD). Therefore, this treatment is still associated with a high morbidity and mortality, as well as a high economic burden. Our previous EU FP6 project, ALLOSTEM, resulted in a number of achievements, including a ‘first in man’ clinical trial that used a highly innovative novel cell selection strategy (Streptamer technology) for the generation of non-ATMP (advanced therapy medicinal product) monovirus specific  T cell products. Continuing from ALLOSTEM, we now aim to develop two novel Streptamer-based clinical  cell selection processes and its corresponding cell products. A multispecific T cell product targeting several viruses and tumors as well as a primary regulatory T cell product targeting GvHD will be developed to market maturity. These two cell products will improve the outcome of allogeneic HSCT. A significant improvement in the outcome and this coupled with a significant reduction of the costs for a large number of patients in Europe will further broaden the application in other forms of cancer of this curative treatment. In order to achieve this goal we assembled a consortium led by the University Hospital of Würzburg with Prof. Einsele as scientific coordinator together with renowned clinical scientists in the field of HSCT (all key players in ALLOSTEM).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intelligent multi-reactive textiles integrating nano-filler based CPC-fibres', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The overall objective of the INTELTEX project is to develop a radically new approach to obtain intelligent textile combining three innovative functions: measurement in a continuous way of mechanical stresses applied to the textile structure, thermal self regulated textile surfaces, and detection of toxic volatile solvents.This multi-sensitivity will be ensured by the integration of Conductive Polymer Composite (CPC) in textiles fibres. CPC, that is obtained by dispersion of conductive particles in a non-conductive polymeric matrix, is a material whose electrical conductivity changes depending on external stresses such as temperature, strain and vapour atmosphere. By processing textiles structures integrating CPC-based fibers, it will be p possible to get multi-reactive textiles where the complete textile act as sensor.This new multifunctional textile will be used for many important applications with customised properties tailored to the following applications: Building application: wall fabric to detect cracks and temperature changes; industrial floors for leakage control and volatile solvent detection / Medical application: medical wear for monitoring body temperature / Protective clothing: combination of the three functionalities in fire-man clothing: monitoring near skin temperature, exterior temperature, mechanical stress (detection of an impact) and toxic volatile solvents such as carbon monoxide in fire.INTELTEX offer radical innovations in 2 areas:-Textiles area: development of a CPC-based technical functional textile combining 3 innovative functions mentioned above.- Materials and nanotechnology area: development of stable carbon nanotube based multiphase CPC by controlling at nanoscale level the dispersion of carbon nanotubes.The inter-particle gap is indeed a