RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Automated procedures for integration of image and map data for change detection.' (1994-1998).

assistant: **Innovation**

Requirement This proposal is in response to a call for proposals in the European Community Environment and Climate programme which specifies a need in Theme 3 (Space techniques applied to environmental monitoring and research), Area 3.1.1 (methodological research), for the development of generic tools and techniques for automated pre-processing, interpretation and integration of remotely sensed and ground data. This proposal directly responds to the requirement for more accurate, robust and automated procedures for geometric correction, techniques for image segmentation and feature extraction and integration of Earth observation data in GIS. Objectives  The primary objective is to develop a software which will automatically register images to maps, or other reference systems, and detect change which has taken place between the time of compilation of the map and images at various subsequent times. The system will handle all types of optical and microwave image data from high resolution optical data to medium resolution data such as Thematic Mapper and ERS data. Such a system will greatly facilitate the use of data from earth observation and speed up the operations of environmental monitoring and the detection of change due to long term or short term processes. The secondary objectives are to bring together a transnational team of scientists and users which will cover a wide range of European cultures and to make use of these skills for the benefit of application scientists and users throughout the Community. The consortium The consortium includes universities from UK, Germany, Sweden and Portugal; an international government sponsored production agency from Spain and a commercial company from UK. The project would make use of the following skills and experience: - combin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study of the immune response in patients with Candidiasis' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Candida species, especially Candida albicans are acquired as mucosal and gastrointestinal tract commensals from the maternal vagina at birth. Delayed type hypersensitivity and the presence of low levels of Candida alblcans become pathogenic under circumstances that alter the anatomic, hormonal, microbial or immunologic milieu.These fungi colonize mucosal surfaces by attaching to epithelial cells by a presumed polysaccharide (mannan) ligand system. Recent studies indicate that antibody and cell immidiated immunity, phagocytosis and alternative complement pathway play essential role to the protection against Candida albicans. Deficiency of one or both arms of the immune system enhances the Candida infections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Serotonergic modulation of cortical activity in vivo: from neurons to networks and implications for autism spectrum disorders' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Anti-depressant drugs such as fluoxetine (Prozac) increase levels of serotonin (5HT) in the brain, but little is known about how they affect the function of the nervous system. 5HT is implicated in a wide spectrum of brain functions and disorders. However, its precise role remains controversial and enigmatic. This is partly due to the previous inability to adequately isolate 5HT action in vivo. Recent developments in genetic tools and imaging techniques now offer an unprecedented opportunity to investigate such mechanisms in the living brain. This project aims to isolate 5HT transmission in the cerebral cortex and determine the precise cellular mechanisms underlying serotonergic neuromodulation of brain activity. Our objectives are to determine the action of 5HT in awake-behaving animals in three main ways: (1) on specific neuronal populations, at the network and single-cell level, by the local application of 5HT modulators (including fluoxetine); (2) when endogenously released, by controlling 5HT neuronal activity with optogenetic tools; and (3) on pathologic cortical network activity in an animal model of autism spectrum disorders. We will use the primary visual cortex as a model cortical area, investigating the role of 5HT in visually-evoked and activity-dependent cortical activation under normal conditions and during network dysfunction in autism spectrum disorders. In this project we will use state of the art in vivo two-photon calcium imaging and advanced genetic tools, including optogenetics. These cutting edge techniques will allow us to precisely activate 5HT neurons and measure the resulting effects on neuronal populations with single-cell resolution. The results will apply beyond the visual system to more broadly inform on cellular mechanisms of 5HT action in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Second-Order Nano-Oxides for Enhanced Nonlinear Photonics' (Chi2-Nano-Oxides), addressing dissemination and exploitation.

assistant: **Impact**

Nonlinear optics is present in our daily life with applications, e.g. light sources for microsurgery or green laser pointer. All of them use bulk materials such as glass fibers or crystals. Generating nonlinear effects from materials at the nanoscale would expand the applications to biology as imaging markers or optoelectronic integrated devices. However, nonlinear signals scale with the volume of a material. Therefore finding materials with high nonlinearities to avoid using high power and large interaction length is challenging. Many studies focus on third order nonlinearities (described by a χ(3) tensor) present in every material (silicon, graphene…) or on metals for enhancing nonlinearities with plasmonics. My approach is to explore second-order χ(2) nanomaterials, since they show higher nonlinearities than χ(3) ones, additional properties such as birefringence, wide band gap for transparency, high refractive index (n>2), and no ohmic losses. Typical χ(2) materials are oxides (BaTiO3, LiNbO3…) with a non-centrosymmetric crystal used for wavelength conversion like in second-harmonic generation (SHG).The key idea is to demonstrate original strategies to enhance SHG of χ(2)  nano-oxides with the material itself and without involving any hybrid effects from other materials such as plasmonic resonances of metals. First, I propose to use multiple Mie resonances from BaTiO3 nanoparticles to boost SHG in the UV to NIR range. Up to now, Mie effects at the nanoscale have been measured in materials with no χ(2) nonlinearities (silicon spheres). Second, since χ(2)  oxides are difficult to etch, I will overcome this fabrication issue by demonstrating solution processed imprint lithography to form high-quality photonic crystal cavities from nanoparticles. Third, I will use facet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Miniaturized hyperspectral imaging sensors to empower climate-smart agriculture practices' in the context of a Horizon Europe call.

assistant: **Objectives**

Agriculture plays a crucial role in climate change adaptation and mitigation, and needs to feed a growing population while reducing its 22% contribution to greenhouse gas emissions. Climate-Smart Agriculture (CSA) emerges as a solution, promoting sustainable development through practices that enhance productivity, resilience and reduce greenhouse gas emissions. CSA employs data-driven approaches, such as mapping data with hyperspectral imaging, for agricultural operations like soil testing, crop scouting, and irrigation management to improve crop yield. Despite its potential, hyperspectral imaging adoption in agriculture is hindered by expensive, heavy, and environmentally unfriendly sensors. This proposal advocates for miniaturized Hyperspectral Imaging Sensors (HISs) using organic materials (OMs) to address current challenges, including spectral resolution, cost, portability, scalability, and environmental impact. Building on our success in ultra-miniaturized spectrometers through bandgap and interface engineering, we aim to combine our miniaturization approach with OMs. We will create a groundbreaking new generation of OM-based miniaturized HISs with improved performance, reduced cost, greater portability, lower power consumption, scalability, and sustainable fabrication. We will also collaborate with industry players to ensure alignment with market needs. To pave the way for commercialization, our plan involves mapping the innovation in the hyperspectral imaging market, identifying market segments and stakeholders, and formulating an initial business model. We aim to make hyperspectral imaging more accessible, encouraging wider adoption of CSA practices among farmers and contributing to a healthier and more sustainable future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Beta cell GABA secretion: route, physiological function, and potential for pharmacological modulation in diabetes therapy' to be submitted under Horizon 2020.

assistant: **Abstract**

According to the World Health Organisation, diabetes affects 422 million people worldwide, over 8% of the entire adult population. The progression of both type 1 and type 2 diabetes is characterised by a decrease in the number and function of beta-cells within pancreatic islets. It has recently been demonstrated that the neurotransmitter γ-aminobutyric acid (GABA), which is produced and secreted from beta cells, is able to slow and even reverse this loss of beta cell capacity. This finding has caused great excitement as treatments which directly address beta cell degeneration would revolutionise diabetes therapy. In order to realise this potential, it is essential that we understand the biogenesis, storage, and secretion of GABA in addition to its functional effects upon islet cells. I therefore propose to characterise a suggested route of GABA secretion from beta cells, assess its role in signalling between islet cells, and identify pharmacological modulators of GABA secretion. This study will be hosted by Patrik Rorsman (University of Gothenburg) with a secondment to AstraZeneca (Mölndal). This interdisciplinary study will combine my experience of applying cutting edge proteomics and genetic editing techniques to the study of protein trafficking with my host's world-leading expertise in islet cell physiology. Successful completion of the proposed work program will reveal fundamental details of islet GABA signalling and likely identify new therapeutic targets for the treatment of diabetes. Furthermore, during a cross-sectorial secondment to AstraZeneca I will carry out a high-throughput phenotypic screen to directly identify small molecule modulators of beta cell GABA secretion.


**Keywords:** GABA, Beta-cell, Secretion, Synaptic-like Microvesicle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Shipbuilding Laser Welds: an integrated system for Assurance and Co ntrol of Quality' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives and content The main strategic aim of the research is to contribute to the recovery of the competitiveness of the European shipbuilding industry, making it possible the industrial use of the laser welding technology in the construction of ship structures. The potential benefits are expected from an increase in productivity and, of even more importance, in quality and accuracy of the laser welded structures. The project is aimed to give the necessary confidence on the laser welding process to the Shipbuilders and the Classification Societies, by the development of an integrated Quality assurance/Control system to be used in laser welding plants. The research will also focus on a systematic study on the influence of steel composition and welding parameters on the quality of the laser welds, and on the study of acceptance criteria for weld defects in laser welded ship structures, based on a fitness for purpose approach". It is expected that this part of the research will contribute to the improvement/extension of the Guidelines for the approval of CO2-Laser Welding recently issued by the European Classification Societies. In order to be able to accomplish the research aims and realise a prompt and effective exploitation of the results, the project Partnership has been set up matching the expertise of: Technological partners:  FORCE INSTITUTE: with its skill in Production Technology, Material Technology, Inspection and Testing, Energy and Metrology, Sensor Technology,  CSM: with its skill in the material small and full scale testing, in the data elaboration for metallurgical interpretation and theoretical evaluation and prediction,  ALFA LASERTECHNIK: with its particular skill in Emission light analyser system. End-users: two major European shipyards: ODENSE Stee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New chemistry and catalysis with hydride compounds' (HYDROCHEM), addressing dissemination and exploitation.

assistant: **Impact**

The topic of this RTN is essential for the formation and continuous development of a new generation of young researchers, as well as for updating the senior participants. The interdisciplinarity of hydride research (including organic and inorganic syntheses, spectroscopy, electrochemistry, catalysis, crystallography, and theoretical expertises) requires exposure of the young researchers to a wide palette of different skills, all of which are represented in the proposed, Network. The young participants will be required to move around the different laboratories, visiting at least two laboratories for a total of 2 months (for a 1 -year appointment) within the Consortium, in addition to their principal place of work. Each researcher will be trained by using the host country language. The young scientists will also be required to present their work at regular Network meetings and at specialized international conferences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High density connection implementation' (HIDENIMP), addressing dissemination and exploitation.

assistant: **Impact**

Each end user partner in the project has designed one or two demonstrator applications. These were made into etched foil screens, printed and then tested. These applications were as follows- Lange coupler working at 7-10 GHz and showing comparable high frequency performance to an equivalent thin film device: by Extec Hybrids.- Tchebycheff cascade filter. The virtually slump free printing enabled by the µ-screen /Heraeus gold ink combination allowed fabrication of devices down to 37µm gap working at 16 GHz: by Extec Hybrids.- Pressure sensor on steel diaphragm. This is a low cost small size device which will supplant traditional devices and, unlike the latter, does not require an additional fluid medium to operate: by Extec Hybrids.- Humidity sensor : by Hymec.- Miniaturised filter circuit : by Hymec.- MCM interconnect. This application had tracks and gaps down to 50µm and highlighted the need for good housekeeping/cleanliness and ensuring the screen was clear of cleaning solvents. Initial difficulties in obtaining good resolution were resolved by moving to the Heraeus gold: by Alcatel.- Humidity sensor for low cost, miniaturised industrial applications: by Microhybrid.- Flip chip on ceramic in silver palladium ink technology - preparation for a new mounting technology for naked chips: by Microhybrid.- Microwave test circuit as comparison with thin film and photoimageable systems for LTCC. This circuit was by far the most complex made during the project comprising many different fine microwave circuits and also large pad areas. This application was particularly valuable in providing the impetus to develop more sophisticated design tools for screen hole patterning (and thereby providing a useful indicator of the design costs involved in a more advanced circuit), demonstra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Arabidopsis insertional mutagenesis for functional analysis of sequences identified by ESSA' (1994-1998).

assistant: **Concept**

The ESSA and other International Sequencing programmes of the Arabidopsis genome are projected to produce sequence information of enormous scientific and potential commercial use. For efficient use of this potential, it is essential to determine the function of novel genes and ORFs uncovered by the genomic and cDNA sequencing programmes. To establish a link between different programmes aiming at the structural and functional analysis of the Arabidopsis genome, we propose here a 'target selected gene inactivation' approach. This approach is based on the application of insertion elements, such as the T-DNA of Agrobacterium and heterologous transposons, which have been used with a great success for the isolation, mapping and functional analysis of gene mutations in Arabidopsis. Our proposal aims to achieve a saturation insertional mutagenesis of the Arabidopsis genome, in order to identify mutations in any gene of interest. The identification of mutated genes by sequence based PCR and gene fusion methods can correlate information about DNA sequence, map position and phenotype. This strategy involves the saturation of the Arabidopsis genome with an assortment of T-DNA and transposon insertions to identify insertional mutations in target genes, the sequence of which is known. Analogous methods have been used efficiently in higher eukaryotes carrying active endogenous transposons to complement or replace the laborious and complicated gene replacement techniques. To quickly reach genome saturation, the introduced T-DNA and transposon insertions in the Arabidopsis genome will be complemented by novel techniques, such as gametic transposition. Methods for T-DNA primed genomic sequencing and comparison with existing databases will address questions about insert distribution, inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The interplay of learning and motivational systems in addictive behaviour' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

An ability to predict the consequences of one’s actions is the hallmark of adaptive intelligence. Learning involves the updating of predictions based on past experience, a process thought to be driven by dopaminergic neurons. Dopaminergic systems can also impart motivational control over learned behaviour. Drug-induced dopamine release can subvert these adaptive systems and link desire for addictive drugs with particular behaviours, environmental cues and motivational states.A fly learning to associate an odour with impending punishment requires synaptic input from the PPL1 cluster of dopaminergic neurons to mushroom body neurons, where olfactory memories are stored. A subset of PPL1 neurons is also responsible for satiety-dependent appetitive memory retrieval. The PPL1 cluster of dopaminergic neurons therefore represents a potential site where learning and motivational circuits intersect.I will use optogenetic and genetic methods to address three specific aims directed at understanding the learning algorithm and its subversion by addictive drugs. 1) I will establish transgenic lines providing genetic access to subsets of PPL1 neurons.  2) I will use an optogenetic reporter to monitor the activity of the PPL1 neurons in vivo, in order to test the hypothesis that PPL1 neurons encode the prediction errors used to update valuations during learning. The effect of drugs of abuse on this process will be determined. 3) I will use a single-fly behavioural assay to establish which cells are necessary, and which sufficient, to drive learning and to test the effects drugs of abuse on learning. A new learning based behavioural assay of addiction will also be developed for gaining access to the motivational component of addiction in Drosophila.