RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'B cells, splenic marginal zone, and complement -as opsonin and inflammatory mediator- in the immunopathogenesis of virally induced Type 1 Diabetes' (CODIA), addressing dissemination and exploitation.

assistant: **Impact**

Approximately 150 million people are affected with diabetes mellitus worldwide. One form of diabetes, Type I diabetes, is an autoimmune disease that accounts for about 10% of all cases. It is mediated by T cells of the immune system that turn against the host (autoreactivity), and specifically destruct insulin-producing beta-cells of the pancreas. The resulting lack of insulin leads to chronic elevated blood sugar, and ultimately contributes to blindness, amputation, renal disease, and premature death.Both genetic and environmental factors play a role in the development of Type I diabetes. Two widely used rodent models emulate aspects of human disease: while the NOD mouse strain is genetically susceptible and develops disease spontaneously, the RIP-LCMV transgenic mouse model requires an external stimulus, i.e. viral infection, to develop diabetes. This grant application contains a proposal to pursue clues from both literature and preliminary experiments that certain immunological factors (i.e. complement, B c ells, the marginal zone), normally associated with the NOD system, might also influence virally induced diabetes development. Defining shared immunological aspects between the two models could help further clarify the immunopathogenicity of human Type I diabetes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'COVID-19 Telemedicine – an infectious disease management tool for governments all over Europe that will reduce casualties from COVID-19 as well as prepare governments for the next wave of epidemics.'.

assistant: **Innovation**

COVID-19 telemedicine will provide the solution for remote monitoring and telemedicine for COVID-19 patients. The platform is developed for COPD and heart patients over the past 6 years and with this project we will be able to innovate home-monitoring, scale it up massively and collect big data to analyse the development and patterns through AI. The result will be a fully rolled-out infectious disease management tool for governments all over Europe that will reduce casualties from COVID-19 as well as prepare governments for the next wave of epidemics.The company is formed to meet the need for a solution for the COVID-19 outbreak. This innovation forms the foundation of the company and the team is put together because they are the right people to execute the vision of actually making a major impact against the novel corona virus. They are experts in scaleup, product development, fundraising, marketing and communication. The support and interest in the solution is massive even at this TRL 8 stage of the first two parts of the full innovation that is threesome. This innovation project will elevate the solution to save lives!
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'THE SCIENCE, PHILOSOPHY, AND POETICS OF EXPERIENCE IN LATE MEDIEVAL ENGLAND' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The project aims to produce the groundwork for a larger and more ambitious interdisciplinary study of the ‘poetics of experience’ in English vernacular poetry, ca. 1360–1450, in the context of the wider intellectual and scientific developments in European scholastic Philosophy, Theology, and the Natural Sciences over the longer period between c 1215 and 1500. The primary aim of the project is to explore the full range and complexity of the engagement with experience found in the work of English poets working between 1360 and 1450, and evaluating the larger cultural and intellectual-historical significance of what we call an emerging ‘poetics of experience’. A related, broader aim is that of exploring the divergence between the medieval and the modern understanding of ‘experience’, shaped by the fundamentally different models of science and knowledge that dominate those two historical periods. While the project concentrates on literary texts in the vernacular (English and, to a lesser extent, French), it aims to provide a much more nuanced and precise description of the interactions between Latin, academic discourses on experience, and vernacular explorations of this important topic. Materials examined will therefore include the writings of scholastic authors on experience, with particular attention to the work of English (or rather ‘insular’) authors, as well as the work of scholastic thinkers whose ideas demonstrably contributed to shape the wider debate on experience in England during the period in question. Beyond this, the project will also examine evidence provided by non-scholastic Latin texts and discourses on experience that would have shaped the immediate cultural and intellectual environment within which English poets wrote.This will include, for instance, mon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improvement of production, stability and functional properties of exopolysaccharides from thermophilic lactic acid bacteria to obtain natural products with enhanced texture and quality' (1994-1998).

assistant: **Innovation**

Many processes and products are dependent on stable complex interactions between different polymers. Thus the food industry world-wide uses 70,000 tonnes of polysaccharides as thickening agents, stabilisers and texturisers per year. This market is expanding as products become more complex and diverse. Plantderived additives such as starch, cellulose, pectin, guar gum, tragacanth are commonly used to modify texture and viscosity. Alginate, carageenan and chitosan from seaweed and crustaceans are similarly used. The use of microbial xanthan is recent, although many strains of lactic acid bacteria (LAB) associated with natural fermentations (milk, meat, cereal, grain and legumes) also produce polysaccharides.  Exploitation of novel heteropolysaccharides from LAB to improve food quality and for development of healthy foods can only be realised if structure/function relationships and mode of synthesis are known. This requires an understanding of how variability in composition and yield occurs; how it may be controlled at the genetic and biochemical level; how synthesis can be enhanced by process engineering and how exopolysaccharide structure relates to the physical properties displayed in the food. Work under the previous FRAMEWORK programmes has provided knowledge of genetic maps, particularly for the lactococci, there is still a need for establishing protocols at the process control level. This is particularly so for the thermophilic strains of LAB, which are now known to produce complex heteropolysaccharides with greater potential. The programme falls within Area 3 (Generic Science) and has particula relevance in understanding the role of microorganisms in food systems (dairy products in this case); the influence of metabolites (exopolysaccharides) on micro-structure and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'International Workshop Foliations-Geometry and Dynamics Revisted""' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

WORKSHOP devoted to different aspects of the theory of foliations such as: 1. Topology of foliations (especially, of 3-manifolds and knot complements, 2. Riemannian geometry of foliations (in particular, on hiperbolic spaces), 3. Dynamics of foliations and related structures (such as groups and pseudo-groups of transformations), 4. Structures related to foliations (such as confoliations, contact and symplectic structures).ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00051-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Incorporation of new technologies in the european precision foundry industry' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The use of rapid prototyping models and simulation software in the precision foundry industry has brought distinct improvements in terms of time to market new products, cost savings, feeding design, opening of new markets etc. The main objective of this network is to promote the use of standard procedures for the use of these tools and to analyse the environmental issues related to the foundry industry. A special effort will be made to disseminate these results at a European level.The approach to achieving these objectives is the creation of an European network with 20 experienced partners that will work in the following main workpackages:i) Rapid prototyping;ii) Simulation software;iii) Environmental issues;iv) Dissemination and exploitation of the results;v) Management and coordination of the network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'International Collaboration on Integrated Photonics Technologies for Advanced Bioapplications' under Seventh Framework.

assistant: **Concept**

The proposed ‘iPhoto-Bio’ is an international research staff exchange programme - ‘International collaboration on integrated photonics technologies for advanced bioapplications’. It aims to create a worldwide networking and knowledge transfer between six world-leading universities/institutes from five different countries: the United Kingdom, Spain, Brazil, China and the United States.The objective of the proposed programme is to establish long-term stable research cooperation between the partners with complimentary expertise and knowledge. The project objectives and challenges present a balanced mix between industrial application focused knowledge transfer and development and more far-looking studies for potentially ground-breaking applications by exploiting new emerging opportunities with integration of photonic components, micro-nano-bio systems, functional techniques, and innovative materials for advanced biosensing and biomedical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel Ultra-Sensitive Infra-Red Absorption Laser Sensors' (NUSIRALS) targeting Seventh Framework.

assistant: **Abstract**

In-line and in-situ fast ultra-sensitive detection of gaseous species at part per billion and part per trillion with ability to distinguish isotopomers without any pre-processing of gas sample is of high interest in chemistry, medicine, geology, physics, various other sciences and industries. Recent technology achievements in development of compact and robust tunable near-infrared and mid-infrared lasers open a door to new applications of optical sensors based upon laser absorption spectrometry. Nowadays, in-situ portable laser sensors based upon direct absorption detection with a mid-infrared quantum cascade laser or a near-infrared diode laser and large volume long path length multi-pass optical cell can compete in accurate isotope-ratio measurements even with ion-mass spectrometers. But in order to reach new horizons significant improvement in sensitivity is necessary. The aim of the project is to develop novel approach of ultra-sensitive gas sensor based upon laser absorption spectrometry and demonstrate absorption sensitivities limited by a shot noise which is caused by the fluctuations of detected photons. The technology based upon frequency modulation of laser, optical locking of the laser to high finesse optical cavity formed by high reflectivity mirrors and signal detection at frequency of free spectral range of the cavity will be developed and tested. We expect to demonstrate highest absorption sensitivities. Laser sensors based upon this technique and mid-infrared and near-infrared lasers will be able to measure molecule concentrations at levels of part per trillion per volume. Robustness and ultra-sensitivity of the developed sensors, knowledge and technology transfer within the project will contribute to widespread implementation of laser sensors in on-line
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project '6th and 7th Workshops on Non-linear Dynamics and Earthquake Prediction' (1998-2002).

assistant: **Concept**

The Abdus Salam International Centre for Theoretical Physics has been organizing workshops on non-linear dynamics and earthquake prediction since 1991. The methods of non-linear dynamics are applied to understanding the instability of the Earth lithosphere. Earthquake prediction is an intrinsic part of the problem, pivotal for understanding dynamics of lithosphere as well as for reduction of disasters. Earthquakes and some other dangers are governed by non-linear systems, which are hierarchical and have an intermediate number of degrees of freedom: an earthquake-prone or a creep-prone region, harbouring high risk objects; a mega city, on a way to self-destruction. The prediction of these disasters, which is a critical component of their reduction, is a very difficult problem due to the absence of an adequate theoretical base of prediction research, in particular, to the impossibility of understanding a non-linear system by studying it piece by piece. Integration of modelling and phenomenology of earthquake occurrence should help overcome the difficulties, connected with the absence of fundamental constitutive equations and the impossibility of direct measurements at the depth, where the earthquakes originate. Specifically, the efforts are focused on the interface between analysis of geophysical observations and mathematical models of chaotic systems. Among practical aspects, large attention is given to accuracy and statistical significance of prediction methods, their rate of errors, and to interaction with disaster management authorities.The following developments in science and technology form the basis for modelling the lithosphere dynamics and, therefore, for understanding and prediction of earthquakes:- non-linear dynamics with its concept of chaos, self -organizat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanisms of Auxin-dependent Signaling in the Endoplasmic Reticulum' (AuxinER) targeting Horizon 2020.

assistant: **Abstract**

The phytohormone auxin has profound importance for plant development. The extracellular AUXIN BINDING PROTEIN1 (ABP1) and the nuclear AUXIN F-BOX PROTEINs (TIR1/AFBs) auxin receptors perceive fast, non-genomic and slow, genomic auxin responses, respectively. Despite the fact that ABP1 mainly localizes to the endoplasmic reticulum (ER), until now it has been proposed to be active only in the extracellular matrix (reviewed in Sauer and Kleine-Vehn, 2011). Just recently, ABP1 function was also linked to genomic responses, modulating TIR1/AFB-dependent processes (Tromas et al., 2013). Intriguingly, the genomic effect of ABP1 appears to be at least partially independent of the endogenous auxin indole 3-acetic acid (IAA) (Paque et al., 2014).  In this proposal my main research objective is to unravel the importance of the ER for genomic auxin responses. The PIN-LIKES (PILS) putative carriers for auxinic compounds also localize to the ER and determine the cellular sensitivity to auxin. PILS5 gain-of-function reduces canonical auxin signaling (Barbez et al., 2012) and phenocopies abp1 knock down lines (Barbez et al., 2012, Paque et al., 2014). Accordingly, a PILS-dependent substrate could be a negative regulator of ABP1 function in the ER. Based on our unpublished data, an IAA metabolite could play a role in ABP1-dependent processes in the ER, possibly providing feedback on the canonical nuclear IAA-signaling.  I hypothesize that the genomic auxin response may be an integration of auxin- and auxin-metabolite-dependent nuclear and ER localized signaling, respectively. This proposed project aims to characterize a novel auxin-signaling paradigm in plants. We will employ state of the art interdisciplinary (biochemical, biophysical, computational modeling, molecular, and genetic) me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Battery Passport for Resilient Supply Chain and Implementation of Circular Economy'.

assistant: **Innovation**

The battery, although central to the green transition of road transport, currently suffers from a supply chain that lacks traceability, sustainability, resiliency, and circularity. Critical Raw Materials (CRMs) are essential for battery manufacturing. The explosive growth of electric vehicles, driven by climate neutrality policy objectives, will pressure the CRM supply chain and increase EU dependency on third countries, resulting in decreased competitiveness for EU automotive and battery manufacturers. Implementing the digital battery passport (DBP) concept in the battery value chain could resolve these issues.The main goal of the BASE project is to develop, validate, and implement a working DBP service, as mandated by the “Regulation.” This will be achieved by exploiting data collected through a number of constantly evolving tools and methods, ensuring a transparent, secure, and cost-efficient platform operation, while also catalyzing the growth of circular businesses. BASE will develop transparent methodologies to calculate battery performance and ESGE indicators, ensuring traceability down to the CRM level throughout the entire battery value chain. In the physical domain, this will be achieved through the mass balancing approach. On the data management side, by exploiting distributed ledger technology, BASE will ensure built-in data authenticity verification along the value chain, with no data duplication, avoiding data manipulation, assuring privacy by design, and promoting data interoperability.The DBP will provide up-to-date and accurate data on battery performance indicators, remaining useful life, dismantling, material composition, and safety. This will allow for an increase in the useful service life of batteries and more efficient recycling, which will enhanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Systems Biology of Stem Cells and Reprogramming' in the context of a Seventh Framework call.

assistant: **Objectives**

Stem cells are central to emerging concepts in health, medicine and therapy. The realization that specific cell reservoirs retain multipotency for tissue establishment and replenishment has implications for both the emerging field of regenerative therapy and the long standing problems of cancer, ageing and degenerative diseases. Recently the prospects for regenerative therapy have been boosted by the breakthrough finding that somatic cells can be reprogrammed into pluripotent embryonic stem (ES) cells upon expression of ES cell transcription factors. This astonishing finding further emphasizes the need to understand stem cell biology. Most of the information acquired on stem cells so far is empirical. Recent progress in systematic and computational methodologies, including seminal contributions by the applicants, permits a new approach to stem cell biology. We can now describe the systems biology of stem cells. This proposal is based on the importance of stem cells in future medicine and the need to understand the fundamental mechanisms that regulate their potential to differentiate towards specific lineages. We aim to gather the information required to understand the regulomes of key stem cells, particularly the transition between embryonic (ES) and neural (NS) cells. NS cells can be readily reprogrammed back to ES cells. We will systematically gather proteomic, transcriptomic, regulomic, live cell and cell cycle data to understand the ES – NS axis comprehensively (in both directions). We will validate the regulatory data by functional interrogation using RNAi screens and tests, complemented by quantitative fluorescent read-outs. To broaden the fundamental and medical relevance of the insights, we will pursue selected studies on other stem cells (e.g. HSCs), and their