RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanostructures for biology' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

I propose to employ our advanced capabilities for nanofabrication to explore new biology at the single-molecule and single-cell level. I choose to specifically address two directions of intense scientific interest: (i) With my team I will develop and exploit solid-state nanopores for the study of real-time translocation of individual biomolecules. In the past few years, my group has attained a leading position in this field and we want to apply our advanced knowledge to push the technology and use it to resolve some pressing questions in cell biology and biotechnology. Specifically, we will explore screening of DNA-protein complexes at the single-molecule level, and we will build biomimetic nanopores to address the physical mechanism of selection and controlled molecular transport of the nuclear pore complex. (ii) We will use nanofabrication to create well-defined landscapes for bacteria. This will allow biophysical studies of the interaction between bacteria and their habitat with an unprecedented control of the spatial structure and habitat parameters. I strongly believe that this approach constitutes a major new tool to experimentally address a number of fundamental issues in the ecology and evolution of bacteria for the first time in a controlled environment. Additionally, it opens up a way to explore the biophysics of bacteria in confined space, where we will study a new bacterial phenotype in nanofabricated slits which we recently discovered. While this research is primarily driven by the quest for understanding physical mechanisms in biology, it can also be expected to have profound impact on applications in antibiotics, gene therapy, and DNA sequencing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tracing virus-specific CD8+ T cell clonotype zonation and function in humans', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The current Covid-19 pandemic highlights the need to gain better understanding of precise mechanisms that enable immune control of viral infections. Although it is established that CD8+ T cells are required to suppress viremia, most view these cells simply as ?killer T cells? based almost exclusively on studies of blood. I recently discovered that efficient immune control of HIV is mediated primarily by non-killer resident memory CD8+ T cells, whereas CD8+ T cells with high ?killer instinct? are mainly confined to the vasculature. These observations force a reevaluation of how antiviral CD8+ T cells are distributed anatomically and function in the tissue spaces where most viruses replicate. Using cutting-edge single-cell technologies on unique paired tissue samples from human organ donors, my aim here is to challenge prevailing concepts in the field of adaptive immunology and reassess how and where CD8+ T cells actually target viruses in the human body. My group will first use single-cell barcoding techniques to establish a reference map of CD8+ T cell clones specific for multiple viruses across tissue sites. We will then dissect this information to determine whether distinct resident memory CD8+ T cell clones and/or subsets exhibit differential antiviral functions across tissue sites. In parallel, we will use more mechanistic approaches to define the epigenetic imprints and functional properties of antiviral CD8+ T cells, aiming to determine to what extent these features are shaped by subset fate, anatomical location, and/or the nature of the expressed T cell receptor. A specific emphasis throughout this project will be to translate the emerging knowledge to the field of Covid-19, aiming to understand how CD8+ T cells control SARS-CoV-2. This ambitious but technically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Experimental and theoretical investigation of electron transport in ultra-narrow 1-dimensional nanostructures' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The main objective of the Ultra-ID Project is to study the fundamental size limits, when the electron transport in one-dimensional (1D) systems can be considered qualitatively similar to macroscopic regime, and to explore qualitatively new phenomena appearing below the certain scale. Project will focus on fabrication, theoretical and experimental study of electron transport in the state-of-the-art narrow 1D objects: normal metals, superconductors, semi conducting heterojunctions and carbonnanotubes. Principal technological objective of the Project is to elaborate old and develop new methods ofmicrofabrication, pushing the reproducible limit of 1D object fabrication down to ~ 10 nm scale. Three independent, but complimentary methods will be used for fabrication of metallic systems: high-resolution e-beam lithography, electrochemical growth of ultra thin Nan wires, and progressive reduction of the effective diameter of pre-fabricated 1D objects by plasma etching. Principal technological objective related to activity with 1D semiconductors is the fabrication of high-quality systems enabling application of external potential. Main technological objective related to electron properties of carbon annotate is the fabrication of structures suspended on top of a terraced plane or a cleaved edge of super lattice. Research activity with normal electron transport will be concentrated at three main topics:metal- insulator transition in ultra-thin wires, electron lecherous in 1D limit, peculiarities of electron transport in 1D systems with controlled external periodic potential. Study of superconductors will be focused on the problem of quantum phase slips in ultra-thin 1Dsystems (wires and rings). Experimental part of the scientific activity will include state-of-the-art low noise t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Neoadjuvant Nanomedicines for vascular Normalization' under Seventh Framework.

assistant: **Concept**

The aim of my proposal is to establish ‘Neoadjuvant Nanomedicines for vascular Normalization’ (NeoNaNo) as a novel concept for improving the efficacy of combined modality anticancer therapy. This concept is radically different from all other drug targeting approaches evaluated to date, since nanomedicines are not used to directly improve drug delivery to tumors, but to normalize the tumor vasculature, and to thereby indirectly improve drug (and oxygen) delivery. The need for such an alternative concept can be exemplified by taking the (pre-) clinical performance of nanomedicines into account: whereas in animal models, they generally improve both the efficacy and the tolerability of chemotherapeutic drugs, in patients, they often only attenuate the toxicity of the intervention, and they fail to improve the efficacy of the drug. To overcome this shortcoming, I here propose to use corticosteroid-containing nanomedicines, targeted to tumor-associated macrophages (TAM), to inhibit pro-inflammatory and pro-angiogenic signaling by TAM, and to thereby homogenize the tumor vasculature, increase tumor perfusion and reduce the interstitial fluid pressure. As a result of this, the tumor accumulation, intratumoral distribution and antitumor efficacy of subsequently administered chemotherapeutics, as well as of radiotherapy (because of enhanced oxygen delivery) can be substantially improved. To achieve these goals, liposomal, polymeric and micellar corticosteroids, several different animal models, and several different imaging agents and techniques will be used to (I) visualize and optimize nanomedicine-mediated vascular normalization; to (II) potentiate chemotherapy; and to (III) potentiate radiotherapy. These efforts will not only provide a solid basis for a completely new paradigm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High-Throughput Mapping of Antibody Sequences to Antigen Specificity in Placental Malaria' (PAMSEQ) under Horizon 2020.

assistant: **Objectives**

Placental malaria (PM) is a severe malaria complication in pregnancy, in areas with stable parasite transmission. It is a major cause of disease and death among pregnant women and their offspring. PM mainly affects primigravidae, as immunity is developed over successive pregnancies. This naturally acquired protection to PM is mediated by antibodies targeting a parasite antigen called VAR2CSA. Although VAR2CSA is a variable antigen, it has been previously demonstrated that the naturally acquired antibody response is generally broadly cross-reactive (meaning that serum from a multigravidae woman can recognize multiple VAR2CSA variants). However, the results of recently conducted trials of a VAR2CSA-based vaccine to prevent PM showed almost complete variant-specificity of the induced antibodies (only the particular VAR2CSA variant used for immunization was recognized), failing at mimicking what occurs during natural infection. This research project aims to resolve that conundrum by studying in detail the specificity and sequence characteristics of VAR2CSA-specific antibodies generated during natural infection. Specifically, I will collect B cells from Ghanaian women with naturally acquired PM immunity. I will then identify B cells producing antibodies that can react with a panel of recombinant protein variants selected to represent the global variation in VAR2CSA. I will then use an innovative technology (LIBRA-seq) to simultaneously identify the exact antigen specificity of each single VAR2CSA-reactive B-cell and importantly the exact sequence of the antibody encoded by the cell. The latter information will allow me to produce recombinant antibodies to be tested for cross-reactivity towards recombinant and native VAR2CSA variants, and for their ability to neutralize the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PROGRAMME ON COMBUSTION TECHNOLOGIES, HUMAN RESOURCES AND LARGE SCALE FACILITIES IN EU COUNTRIES' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Following on from the first EUROFLAM programme, UWCC will make its large scale combustion facilities available to an expanded number of European technical university graduates already involved in industrial networks for periods of normally up to six months for advanced training. The experiences will include the study of a variety of gas and oil flames at an industrial scale (0.5 to 2 MW) using advanced experimental techniques including a three component laser velocimeter, laser sheet visualisation, phase Doppler optical sizer, plus various heat transfer measurements, gas analysis including chemical species characterisation. The facilities will be dedicated to this programme. Solid and liquid fuel combustion, gasification and pyrolysis including coal and biomass as feed stocks in a cyclone combustor of semi-industrial size as well as various commercial size rigs of fixed bed type. Various computational fluid dynamic software packages will be available on the university's extensive range of computer workstations, giving investigators the opportunity to update their experience on the mathematical simulation of flames/combustion and heat transfer processes. Analysis of experimental and modelling data will be facilitated for the investigators via seminars and modular short courses. All participants will be expected to give a major presentation at a symposium with the EUROFLAM participants from the co-operating institutes and external assessors present. Experience will be provided in a series of flexible modules of normally up to six months duration, allowing a total of 36 investigators over the 36 month long programme (12 per year). Quality of access will be enhanced via the requested RTD Access improvement programme and complemented by TMR fellowships. UWCC will provide/acq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Use of bioavailabilty promoting organisms to decontaminate pah-polluted soils : preparation towards large scale field exploitation'.

assistant: **Concept**

Polycyclic Aromatic Hydrocarbons (PAHs) are priority soil pollutants in Europe. Due to their poor bio availability, they persist in many contaminated sites although they are principally biodegradable. Bacteria of the genera Mycobacterium and Sphingomonas are particularly suited for PAH degradation because of their peculiar metabolic and physicochemical characteristics and might represent the main environmental sink of these chemicals. This project, conceived by seven academic partners and three bioremediation firms, aims at exploiting these organisms in bioremediation. In laboratory and small-scale experiments, it will identify the optimal conditions for PAH removal by these organisms, develop tools that allow activity monitoring in soil and sludge matrices, stimulate the bio availability promoting and metabolic capacities in situ and recomment full-scale technologies that maximise their performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ni-rich, Engineered Cu-ZrN@NiCo LDHs Bifunctional Cathode Catalyst for High-Performance Metal-Air Batteries.' under Horizon Europe.

assistant: **Concept**

The most critical challenges faced by human beings are shortage of green and sustainable energy. One of the most critical aspects of research has focused on the generation of clean and sustainable energy and storing these energies for further use. The European Union's, 8th EAP 2050 priority objective is to achieve climate neutrality in the union and aims to accelerate the green transition and restore the environment. It can be achieved by emerging new technologies in energy generation and storage systems. The battery devices that have aesthetic appeal and multi-functionality inspired the rapid development of sustainable energy sources. State-of-the-art commercial lithium-ion batteries have an energy density of 300 Wh kg-1, which falls short of the expected energy target i.e. 400 Wh kg-1. Metal-Air batteries (MABs) e.g.  Li-O2 aqueous battery shows higher theoretical specific energy (3582 Wh Kg-1) and energy density (2234 Wh I-1); it is about 10 times higher than most batteries in the market today, but only two-fold improvements have been practically reached to date. Therefore, there is a lot of scope for the development of MABs. It has the capability to fulfill the energy demand rising from portable electronic devices, electrified transportation, and grid-scale applications as immersed by the European Battery Alliance. The most challenging issue in the development of MABs is the use of precious metal catalysts and insufficient catalytic activity toward the cathode catalysis. Therefore, we need to develop new cathode catalysts in the field of rechargeable MABs that are environmentally benign, safe, possess high energy density and long cycle life, and consist of low-cost materials.  In this project, we aim to develop a transition metal-based, Ni-rich advanced cathode cata
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hybrid Quantum Integrated Photonics' (HyQuIP) under Horizon 2020.

assistant: **Objectives**

The weirdness of quantum physics is among the most counterintuitive properties of nature. It is traced back to the early theoretical discussions on entanglement between Albert Einstein and Niels Bohr in the 1930s, which was then experimentally observed in the 1980s and became central in quantum information processing, communication and sensing schemes over the past decade. Utilizing the quantum nature of photons has so far been limited to small number of qubits, while being performed on table-top experimental setups composed of a large number of macroscopic components. This sets a limit to the complexity and efficiency of experiments that can be carried out. In HyQuIP, hybrid quantum integrated photonic circuits will be developed to generate, manipulate, and detect photons all on-a-chip to remove the bottlenecks currently limiting scalability of quantum science experiments. Our integrated approach will realize important milestones for fundamental understanding of the quantum nature of photons in addition to on-chip quantum computing to realize the ambitious schemes that have been put forward by theorists over the past decade. We will demonstrate the first fully-integrated, from generation to detection, quantum transceiver with multi-qubit inference on chip. Furthermore, we will explore the exciting regime of reducing the bandwidth of single-photons to zero in a dynamic photonic device. HyQuIP will not only open up new fundamental tests based on the quantum nature of reality and entanglement, it will also open up new applications: In quantum metrology providing superior sensitivity to classical schemes. Also in quantum imaging and lithography where multi-qubit quantum states can achieve super resolution beating the Rayleigh criterion for diffraction limit.  The possibili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CHallenges in Preservation of Structure' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This research and innovation staff exchange programme builds on significant investments made by the national research councils of the European and Third countries involved to support basic research on the topic of structure preserving algorithms. In the last four years, we have established a very fruitful cooperation working on common projects, sharing knowledge and producing a high number of important new results, which already received considerable attention in the scientific community. In the proposed exchange programme we aim at a significant advancement of knowledge through transnational collaborations between the academic partners. We also plan for concrete and systematic activities to facilitate innovation in those fields of technology which can benefit from the research of this proposal. This project will facilitate the use of the produced mathematical results in the innovation of software tools. This will be pursued in collaboration with our non-academic partner MathWorks. We also propose a plan for career development of young researchers in a non-academic environment. We have identified a number of actions to maximize impact not only on the research community but also towards our local, national networks of small and medium enterprises.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The Role of Intention in Language Processing'.

assistant: **Concept**

The ability to use language is one of the defining properties of human cognition. On the one hand, the purely linguistic aspects involved in the comprehension and production of language are a uniquely human faculty. On the other hand, the use of language involves complex, higher-order functioning such as intention, essential to mental life. Indeed, a reader and speaker can choose which written information to consciously process and which words to say, respectively, as well as use these skills for different linguistic purposes. The present project aims at bridging these two prototypically human behaviors, by exploring the role of intention in language processing and we will do so for both the active process which is speaking and the passive process which is reading. Investigating the interaction between language and intention is particularly timely given the increasing amount of evidence in other areas of cognitive science highlighting that cognition arises through the early interplay between input-driven and top-down driven intentional processes. Concretely, the project has three (related) main parts: Part 1 will focus on how the conscious intention to engage in a linguistic act (global goal-directed linguistic intention) affects the way words are accessed and retrieved from long-term memory. In part 2, we will explore how distinct language operations one can use may affect the processing of the same input (local goal-directed linguistic intention). Finally, in part 3 and end goal of the project, we will construct and implement a computational model of how top-down intention can modulate lexical processing,  with the aim to provide a theory of language functioning from a broader perspective on human cognition and goal-directed behavior.""