RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tuning the properties of NanoCarbon with Fluorination' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Low-dimensional carbon structures such as graphene and carbon nanotubes have raised tremendous interest in recent years both from fundamental and technological perspectives. However, the tunability of the density of electronic states of graphene and carbon nanotubes remains a limiting factor for their implementation in modern nanotechnology. It has been recently shown that the energy bandgap of graphene-based materials can be tailored via chemical modification of the graphene surface, e.g. by fluorination. We focus our efforts on tuning the chemical and physical properties of nanocarbon materials using different fluorination techniques and varying the degree of fluorination. A multidisciplinary approach will be applied ranging from fundamental research in chemistry and physics to studying the materials properties for application in electronics, photonics, and biomedicine. It is anticipated that the final outcome of this project will be a novel nanocarbon-based material with specific advanced properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Xenophagy and bacterial avoidance'.

assistant: **Objectives**

Autophagy is an essential process that enables cells to engulf and digest portions of their cytoplasm, thereby accomplishing quality and quantity control of organelles, proteins and pathogens. These homeostatic and adaptive function intricately link autophagy to diverse health and disease states including innate immunity. Microbial pathogens that successfully parasitize eukaryotic cells have evolved to evade autophagic microbial defenses (xenophagy) and subvert the host autophagic responses for their own survival and/or growth. Central to xenophagy is cargo recognition and dynamic rearrangements of membrane-bound compartments to sequester and deliver pathogen load for lysosomal degradation. Microbial adaptation strategies identified to date have targeted both of these crucial and intertwining functions. However, the precise molecular mechanisms underpinning pathogen avoidance of host-cell autophagy and immune responses are only poorly understood. This raised specific questions about host-pathogen interactions: (1) What is the dynamic response of the core autophagy system to bacterial pathogens? (2) How does the autophagy pathway impinge on the endocytic system and how do pathogens subvert intracellular vesicle trafficking systems? (3) What is the molecular machinery involved in detecting cargo and how do pathogens counter this response? This proposal seeks to elucidate pathways and functions involved in xenophagy and to identify mechanisms by which pathogens usurpate the anti-bacterial cell-autonomous defence system. To address these questions, we will employ a highly complementary multidisciplinary platform, which combines biochemical, cell and infection biological approaches with emerging proteomics and high-content imaging techniques. Together, this proposal has the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The Quantum Twisting Microscope - revolutionizing quantum matter imaging'.

assistant: **Innovation**

In this work, we propose to build a radically new type of scanning probe microscope – the Quantum Twisting Microscope (QTM) – that will be the first capable of performing local quantum interference measurements at a twistable interface between two quantum materials. The concept, already established in preliminary experiments, is based on a unique tip made of an atomically-thin two-dimensional material. This tip allows electrons to coherently tunnel into a sample at many locations at once, making it a scanning electronic interferometer. With an extra twist degree of freedom, our microscope becomes a momentum-resolving local probe, providing powerful new ways to study the energy dispersions of interacting electrons in quantum materials. The same microscope, working in a second modality, will be the-first-of-its-kind platform for cryogenic assembly of interfaces between various van der Waals materials with full in-situ control over their twist angle. Finally, in a third modality, the QTM will make a dramatic jump, by two orders of magnitude, in the spatial resolution of electrostatic imaging. This will open a new world of interacting electron phenomena that were so far inaccessible to direct visualization. We have recently built a preliminary room temperature version of this microscope, and already observed striking quantum interference and promising results on all three fronts. By taking this new microscope to cryogenic temperatures, we expect to make multiple discoveries on a variety of fundamental questions in interacting quantum matter.


**Keywords:** graphene, magic angle twisted bilayer graphene, scanning probe microscopes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DEMONSTRATION OF TECHNOLOGIES FOR LOCATION, EXTRACTION AND COMMERCIAL UTILISATION OF GAS FROM ABANDONED COAL MINES' under Fourth Framework.

assistant: **Concept**

The aim is to locate fracture zones related to former coal mining activity and determine optimal position for drilling a large diameter borehole which will be used to extract gas reserves (coalbed methane or coal seam methane) commercially before this energy resource is rendered unusable by flooding or lost by leakage to the atmosphere. Coal seam methane will be sold directly to nearby energy consumers.Innovative aspects of the technology include : 3D virtual reality modelling of mime workings; integration of data with a surface geographic database to choose optimal location for drilling large diameter boreholes into destressed and fractured strata; use of positive displacement gas extraction pumps; and production of abandoned mine gas from workings directly beneath consumer sites thus precluding the need for a pipeline.The project is expected to produce about 700 million Mj/y from the first borehole.The UK's reserves of onshore coal are estimated at about 185 billion tonnes. Assuming an average gas content of 6 Nm³/tonne, the originally in-place coal seam methane reserves were at least 1 trillion Nm³. European coal seam methane reserves are much greater than those of the UK. During mining operations some of this gas was released but a proportion of it collects in voids in the abandoned mines or remains adsorbed in unworked coal.Coalgas has proved in two production tests that this remaining methane can be produced at commercial rates from mine vents. This project aims to extend Coalgas technology to gas extraction boreholes drilled into fracture zones above former mine workings. The project will operate within the context of abandoned coal mines containing very large methane reserves which can be extracted for socio-economic benefit to the former mining communities and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Citizen Assemblies in Europe: window dressing or transformative instruments?' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

To improve and even to save contemporary democracies under huge pressure and attack, a remedy has been attracting a large amount of attention: the strengthening of ordinary citizens opportunities to deliberate on and directly participate in politics. In this regard, many citizens assemblies (CAs) have been implemented by public authorities, especially since the 2010s. Convened through random selection, these assemblies are diversified groups of citizens that deliberate on a public problem and make policy recommendations. Existing research provides detailed descriptions of the internal dynamics of CAs and shows that most citizens are able to deliberate on complex issues. Nevertheless, they fail to identify and explain their more external impacts. In the context of the growing appeal for such mechanisms, CITIZEN_IMPACT asks the fundamental question: are CAs mere window dressing or do they lead to transformations in the functioning of the political system? It radically changes the dominant perspective on CAs by taking stock of several decades of research on policy studies, governance and institutional dynamics. It offers a systematic account of whether, how and why CAs matter in contemporary European countries by elaborating a new multidimensional conceptualisation of their impact: direct impact on policies, indirect impact on civil society and discursive impact on the public sphere. To address these three dimensions, the research design combines different methods to compare macro national trends (frame analysis of the media, survey with civil society organisations) and to disentangle complex processes (process tracing, interviews). Hence, CITIZEN_IMPACT provides a new horizon to tackle, both in the scientific community and the broader society, the role and contribution of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Integrating the tissue-specificity and chronology of hereditary renal cancer predisposition' to be submitted under Horizon 2020.

assistant: **Abstract**

Cancer cells undergo profound metabolic changes. However, little is known about whether and how metabolic changes drive cancer. The discovery that mutations of Tricarboxylic Acid (TCA) cycle enzymes in mitochondria predispose to cancer gives evidence that dysregulated metabolism could drive tumorigenesis. Amongst these, mutations in Fumarate Hydratase (FH) cause Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC), characterised by tumours of the skin and uterus, and renal cancer. Patients inherit one mutated copy of FH and loss of the wild-type (wt) allele occurs in tumours. Fumarate accumulation is the defining biochemical feature of these tumours. However, the mechanisms by which FH loss and fumarate accumulation lead to these tumours is unclear. In ONCOFUM, I want to elucidate the mechanisms that underpin tissue-specific tumorigenesis in HLRCC. I hypothesise that HLRCC occurs via a two-step process. Initially, loss of the wt allele in carriers of a FH mutation leads to FH deficiency. However, most of these cells die and only cells in tissues with the appropriate metabolic hardware survive. In the second step, FH loss in permissive tissues leads to phenotypic changes that lead to cancer. To assess this hypothesis, we will generate a mouse model where we inactivate FH in multiple tissues and elucidate the ensuing tissue-specific reprogramming. Then, using cellular models, we will investigate the molecular consequences of FH loss. In parallel, we will perform a comprehensive analysis of HLRCC tumours to find diagnostic and prognostic tools, and new anticancer targets, which will be validated in vitro and in vivo. The experimental framework developed in ONCOFUM will give unparalleled molecular insights into how cancer develops in different tissues in response to loss
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel nondestructive material testing technique based on a new magn etic field measurement principle' (MANODET) targeting Fourth Framework.

assistant: **Abstract**

Foreseen ResultsThe topic of the joint research proposal is the development of a magnetic type nondestructive material testing technique, with special emphasis on ECT, based on the use of the proprietary Fluxset principle. An important target within the project is the reconstruction of shape and size of the detected defect from the magnetic information by means of advanced inversion methods. Both the sensor design and the development of the inversion methods are strongly supported by different numerical electromagnetic field simulation and optimization techniques.This proposal largely contributes to the stabilization of the RTD potential in the CCE countries by hiring Ph.D. students for this research programme and enabling them to get on hands experience during training with the co-operating partners.The industrial measuring apparatus, which is planned to be developed in the project, will be produced by the Kraft Electronics Co. Ltd, and these equipments will be utilized in various type of ECT measurements at the Paks Nuclear Power Plant in Hungary. The two letters of intent are enclosed to the proposal.The present proposal in the field of Industrial and Material Technologies (design of products and processes, maintainability and reliability) is aimed at the development of an innovative and cost effective measurement method. The final result will be a support tool for reliable, nondestructive testing of crucial material parameters. With the extensive use of mathematical modelling the new system shall be capable of extracting information which will lead to safer operation of essential components in harsh environments.A proprietary high sensitivity sensing principle (Fluxset) has recently been developed for the measurement of weak (0.1 nT- 500 ,uT) DC and low frequency AC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterisation of a novel gene that is differentially expressed in the skeletal muscle of obese and diabetic patients' (1998-2002).

assistant: **Innovation**

A novel gene that was recently discovered in the laboratory of Professor Zorzano will be characterised and functional tests will be performed to identify important aspects of its normal function in vivo and its possible role in skeletal muscle insulin resistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Non-invasive rapid assessment of chronic liver disease using Magnetic Resonance Imaging with LiverMultiScan' to be submitted under Horizon 2020.

assistant: **Abstract**

Chronic liver diseases are called 'silent killers', as clinical symptoms only surface at late stages of the disease, when it is not treatable. Non-alcoholic fatty liver disease (NAFLD), a condition defined by fat accumulation in the liver, and its sub-type non-alcoholic steatohepatitis (NASH) are the major forms of liver disease. Untreated NAFLD/NASH can lead to cirrhosis and to liver failure. 450 million people worldwide suffer from fatty liver disease, which carries several health risks, and causes a huge socio-economic burden. At present, the only way of diagnosing and staging disease is with liver biopsy, which is costly, invasive, and carries some risk. Thus, clinicians are reluctant to use it for people suspected of having NAFLD/NASH. In addition, invasive biopsy is not optimal for serial assessment (e.g. monitoring transplant population for signs of liver rejection). Therefore, there is a lack of an accurate and non-invasive method of assessing liver disease and enabling treatment monitoring. Perspectum Diagnostics Ltd (PD) has developed LiverMultiScan, a novel, non-invasive, quantitative Magnetic Resonance Imaging software tool that displays high diagnostic accuracy for the early assessment of liver disease, and can be used for patient stratification. It has recently obtained regulatory clearance, but it requires additional clinical validation to assure its broad market acceptance and reimbursement. Thus, RADIcAL entails two clinical trials: a) a multi-centre randomised health economic study to validate the cost-effectiveness and added value of LiverMultiScan compared to the standard care pathway for chronic liver disease; and (b) a prospective clinical trial to demonstrate the high sensitivity and specificity of LiverMultiScan as a medical support tool for stra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dynamic imaging the mucosal immune system' (GUTIMMUNOIMAGING) under Seventh Framework.

assistant: **Objectives**

Dendritic cells (DCs) resident just beyond the epithelial cells (ECs) monolayer are able to extend dendrites from the lamina propria across ECs into the intestinal lumen to capture bacteria (1-3). During my post-doctoral studies, I visualized in vivo (1), for the first time, by two-photon (2P) intravital microscopy, the ability of intestinal DCs to project dendrites into the lumen to capture lumenal antigens. I associated this response to epithelial Toll-like receptor (TLR) triggering, providing timing and location for this phenomenon. Resident mucosal DCs are inflammatory anergic (4) and this phenotype is conferred by the mucosal EC-derived factors (5). DCs present in the upper tract, could be non-inflammatory participating to tolerogenic mechanisms. The inducible DCs actively recruited by ECs in response to lumenal bacteria, could play a role in inducing immunity against pathogens (4). These data suggest that the two types of DC extensions might play divergent roles in the intestine. Aim of this proposal is to investigate the dynamics of the intestinal immune response to bacteria using cutting edge techniques. We will proceed by analyzing immune phenotype changes after bacterial infection starting from the epithelial cells and ending with the DCs and their interaction with B and T lymphocytes.  1) We will use Laser capture microdissection to investigate the gene expression profile of ECs in response to lumenal antigens/bacteria at single cell level. 2) We will then investigate the fate of the two DC types (inducible versus constitutive) after sampling the intestinal luminal content. 3) By using intravital 2P microscopy, we will follow the interaction of antigen-loaded DCs with B and T cells. The results of this study will lead to the understanding of basic mechanisms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'System for effective Assessment of driver vigilance and Warning According to traffic risK Estimation' (AWAKE), addressing dissemination and exploitation.

assistant: **Impact**

Around 10-20% of all road accidents seem to be related to driver hypovigilance (fatigue or prolonged inattention). AWAKE project aims to increase traffic safety by reducing the number and the consequences of traffic accidents caused by driver's hypovigilance, by developing a multi-sensor system, including the most promising detection sensors developed so far, such as an eyelid camera, a steering grip sensor, a lane tracker and other sensors monitoring vehicle-related parameters. Their signals will be integrated, through intelligent algorithms, allowing strong system personalization to the specific traffic conditions as well to the driving pattern and physical characteristics of the individual driver. The system will be installed at three demonstrators (city car, luxury car and truck) and will be optimised through 18 pilots in 6 European countries, leading to an efficient and user-friendly driver warning system and to design guidelines and policy recommendations for its implementation.Objectives:- To significantly reduce accidents related to driver's hypovigilance and enhance user acceptance of driver monitoring systems;- To develop a module, that will detect and diagnose in real-time driver hypovigilance;- To develop an optimum, modular, on-time driver warning system, to alert the driver in case of drowsiness, using acoustic, visual and haptic means with different warning levels according to driver's vigilance status and the estimated risk level of the situation;- To develop a module, to estimate the actual traffic risk and adapt a accordingly the provided warning to the driver;- To integrate all these modules in a middle, upper class passenger car and a heavy vehicle demonstrator and profoundly test them in 16 pilots all over Europe.Work description:The user needs rega