RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'An Integrated project for the design and testing of vaccine candidates against tuberculosis: Identification, development and clinical studies'.

assistant: **Concept**

With a global incidence increasing at 2% and two million deaths each year, tuberculosis (TB) demands the highest priority among communicable diseases linked to poverty. In developing countries, the vast majority of the TB cases affect the young adult population, increasing its economic impact. The TB-VAC project aims to develop improved vaccines, particularly for the young adult population. Vaccine candidates and strategies will be optimized for evaluation in Phase I clinical trials. TB-VAC consists of two tracks. Track 1. Optimisation of existing vaccine candidates towards Phase I trials.This track is composed of a strategic research component (WP1, 4 and 5) and a down stream development component (WP6). The strategic research focuses on goal-oriented research to optimize delivery and composition of during FP5 selected, promising candidate vaccines (eg, 72F, Hyb-1,85A) and on identification of correlates of protection and markers of TB disease for monitoring of future clinical trials. The downstream development component will carry out GMP production of optimised vaccine candidates, establish pre-clinical files and carry out Phase I clinical trials in European and TB-endemic countries. According to the results, the Consortium will decide upon a strategy to exploit this portfolio. Track 2. Discovery of new vaccine/antigens (WP2 and 3). This track will carry out innovative back-up research to identify and develop novel vaccines/antigens. In WP3, we will focus on subunit vaccines based on dormancy related antigens. In WP2, we proposes to optimise three selected live vaccine candidates that during FP5 showed improved efficacy as compared to BCG and show promise as vaccines in infants. Thirty institutions will participate at the start of this effort including two vaccine pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SYNergistic SORBents'.

assistant: **Innovation**

This is the “Age of Gas”; disruptive new technologies must develop around the use of gases as fuels, therapies or feedstock chemicals. Specifically, new approaches to gas storage (transportation and delivery) and purification (commodities) are urgently needed to address the large energy footprint, cost and/or risk associated with existing technologies (e.g. chemisorbents). In particular, water and chemical commodity purification are global challenges, each consuming > 10% of global energy output. SYNSORB will reduce the energy footprint of purification processes through crystal engineering (design), characterisation (structure/function) and modelling (binding interactions) studies that enable understanding of how pore size /chemistry impact the properties and performance of physisorbents. Our objective is to find the energetic sweet spots that enable new benchmarks for selectivity and working capacity for gas (e.g. CH4, C2, C3) and vapour (e.g. H2O) purification at practically relevant conditions.Key scientific impacts include the following:(i)    Understanding how pore size/chemistry impact selectivity, binding energy and kinetics of physisorption will afford fundamental knowledge concerning optimal pore size/chemistry for ultra-selective removal of both trace (< 1%) and bulk impurities.(ii)   Trace gas removal from even binary gas mixtures was unattainable by physisorbents until recently, when new classes of ultramicroporous materials, HUMs (introduced by the PI in Nature, 2013, and Science, 2016) and AUMs were introduced. The nature of HUMs/AUMs means that they offer new benchmarks for selectivity by > one order of magnitude vs. zeolites and MOFs, thereby enabling removal of trace impurities.(iii) SYNSORB will address purification of multi-component gas mixtures that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Early Acquisition of Argument Structure' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The planned research will investigate the early acquisition of argument structure, a crucial example of syntax-semantics linking, in Estonian and cross-linguistic comparison. The project investigates 2 to 5-year-old children’s ability to use information from different cues signalling argument structure, namely word order, case marking, and the discourse context. The rich inflectional system and flexible word order of Estonian provide a sharp contrast to English, on which most studies of syntactic acquisition have been based. Estonian constitutes a missing link in the available cross-linguistic research and an ideal language for examining the coalition of cues used for the semantics-syntax mapping task, due to its robust case-marking system, one-to-many syntax-semantics mappings, and its reliance on word order to convey information structure.The proposed research will analyse both the input speech of caregivers and children’s speech in existing naturalistic ’dense data’ recordings of Estonian, and follow these with experimental studies to probe children’s ability to make sense of the information contributed by linguistic cues. The research will place the analyses of the child’s and caregiver’s speech in a broader context, aiming to further the cross-linguistic research programme tracing various paths to adult knowledge of argument structure. The project proceeds by comparing the acquisition of certain constructions in Estonian with differing structural characteristics. Their development will be traced in recorded data, as well as testing comprehension and production in experiments addressing the issue of how much of children’s emerging linguistic knowledge can be characterised as semantic or syntactic. We will also examine the role of the speakers’ immediate context; the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Constrained Democracy: Citizens’ Responses to Limited Political Choice in the European Union' (EUDEMOS), addressing dissemination and exploitation.

assistant: **Impact**

National governments operate under the growing constraints of European integration that limit the choices they can offer citizens and the policy instruments they can use. Yet, despite the centrality of political choice to the functioning of electoral democracy, we know very little about the consequences of constrained political choices for citizens’ engagement in democratic processes. Across Europe, an increasing number of citizens are supporting extreme parties or declining to take part in democratic elections. This project offers the first systematic examination of how the range and substance of political choices offered to citizens in the EU shape democratic perceptions and electoral behaviour. Understanding how citizens perceive and react to the growing constraints on domestic politics is crucial to a diagnosis of European democracy and for an evidence-based debate on reform of EU institutions. Building on the Principal Investigator’s award-winning research on electoral democracy and extensive experience of designing and analysing cross-national surveys and experiments, this project is a pioneering study of the consequences of constrained democracy. It uniquely combines a large-N cross-national analysis of citizens’ responses to mainstream party convergence and case studies of the ‘emergency politics’ of the Eurozone crisis with micro-level experimental work. This project aims to transform the study of citizens’ democratic attitudes and behaviour by focusing on the importance of political choice. By developing and testing a theoretical model of heterogeneous citizen responses to the constrained political choice, the project provides insights into why citizens turn against mainstream parties or exit democratic processes altogether. This further allows EUDEMOS to deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'System-wide discovery and analysis of inositol pyrophosphate signaling networks in plants' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Inositol pyrophosphates (PP-InsPs) are soluble signaling molecules known to play diverse roles in fungal and animal cell signaling. The metabolism of PP-InsPs in plants however is poorly understood and many signaling pathways controlled by PP-InsPs remain to be discovered. Funded by an ERC starting grant, we have previously identified protein sensor domains for PP-InsPs, which allow PP-InsPs to act as central regulators of phosphate homeostasis in all eukaryotes. Genetic disruption of PP-InsP synthesis results in dramatic phenotypes in the model plant Arabidopsis, which however cannot be rationalized by defects in phosphate signaling only. Based on these physiological observations, we generated a system-wide Arabidopsis PP-InsP interactome, using an affinity-matrix absorbed non-hydrolyzable PP-InsP analog. Surprisingly, hundreds of novel candidates from different protein families were identified in this screen, now enabling us to study PP-InsP catabolism and a multitude of PP-InsP-mediated signaling processes. Here, I propose to combine quantitative biochemistry and structural biology with cell biology and genome editing to dissect plant PP-InsP signaling networks at the physiological level and in mechanistic detail. Specifically, we will define the roles for PP-InsPs in plant light sensing and signaling, in flowering time regulation and in plant immune responses. Our ultimate goal will be to investigate the cross-talk between different PP-InsP-controlled signaling pathways and to define central signaling hubs. I envision that the work outlined in this proposal will yield a mechanistically validated system’s-level view of PP-InsP signal transduction in plants, which may allow us to better understand how plants develop and interact with their environment, and that may en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Concept for Ionospheric-Scintillation Mitigation for Professional GNSS in Latin America' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Ionospheric Scintillation is a major threat to GNSS based applications demanding high levels of accuracy, availability and integrity, including EGNOS-based  applications, notably in low latitude areas. The problem is particularly acute in Latin America and will be further amplified with the  solar maximum predicted in 2011-2012.  The goal of the CIGALA project is to develop ionospheric scintillation mitigation and countermeasures to be implemented and tested in professional multi-frequency multi-constellation GNSS receivers. Therefore, the project will leverage R&D activities coordinated between European and Brazilian experts as well as a wide scale ionospheric measurement and test campaign that will be conducted in Brazil with the support of several local academic and industrial partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling Tree Response to Aridity Increase with Traits', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The changes in precipitation patterns that are projected for the coming decades are expected to increase the frequency and intensity of droughts. Despite the potentially dramatic impacts on wood and forest-based ecosystem services, the effect of these changes in the hydrological cycle on European forests is still highly uncertain. One reason for this gap in the knowledge is the inadequacy of the tools currently used to address large-scale land-atmosphere processes at continental scales, the land surface models (LSMs). Indeed, the predictive power of LSMs is hampered by their heavy parameterization of empirical hydrological modules, with parameters fixed per broad plant type irrespective of the environmental conditions. This representation is contradictory to the ecological processes of acclimation and selection and makes the LSMs unsuitable outside of their calibration range especially under extreme conditions. Ecologists have now made progress in describing traits – tree characteristics that define plant growth strategies. Plant traits vary as much within species as between species, as individuals and communities adapt to their environmental conditions.M-TRAIT will bring the latest ecological findings together with a state-of-the-art LSM to model large-scale forest response to droughts. The trait determinants to the drought response of trees will be determined from analysis of worldwide trait databases. The relationships between traits and with the environment will be formulated. The key traits will then be integrated into a forestry-enhanced LSM with an individuals-sampling approach in which a large number of plant growth strategies are initialized and allowed to interact with environmental conditions. The outcome of M-TRAIT will be 100-year simulations of the drought
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Synthesis of novel antifungal agents - concise construction of lanomycin and related compounds'.

assistant: **Innovation**

There is need for the control of fungal pathogens in human medicine and agriculture. Lanomycin, isolated from Pycnidiophora dispersa, is a promising lead for the development of novel antifungal agents. The compound was shown to inhibit the P450 enzyme lanosterol 14a-de- methylase. It selectively inhibits some Candida species.  In this project a simple, general and stereoselective method for the elaboration of lanomycin and related molecules shall be established. The synthesis contains two crucial novel transformations: A dienyl borane shall be used to enantioselectively build two of the stereocenters of the target compound. An allene will be the product of this reaction. This compound might then be cyclised oxidatively to yield a B-ethynyl-pyranoside. There are good indirect reasons to expect that both steps can be realised but, if needed, there are many fall back options. The side chain of the molecule will then be completed by a methylzirconation-palladium catalysed coupling sequence.  It is planned to synthesize diverse analogues of lanomycin for bio-assa Therefore, it will be helpful to adapt this chemistry for polymer supported combinatorial synthesis. The activity results will then point at compounds of increased stability and potency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on '13 MW CHP Plant Based on Biomass Gasifier with Gas Engines'.

assistant: **Concept**

The partners will demonstrate and optimise a novel CHP plant based on biomass gasification on a full scale (13 MW thermal input). In this plant two biogas fuelled engines produce electricity (4 MWe) from gasified biomass. While the district heat (8 MWth) is produced in various heat exchangers. The BGGE CHP plant will be built at an existing CHP plant in Lemvig, Denmark. Since this is the first time that some of the main plant components will be built and integrated on this scale important aims of this project will be the process optimisation and demonstration of the integration. The ultimate goal is to make this technology competitive with the power plants based on fossil fuel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Development of late medieval stone-cut vaults: an invisible bridge between East and West'.

assistant: **Innovation**

This project aims to explore potential connections between medieval stone-cut vaults in the Middle East and similar vaults that suddenly emerged in European regions such as the Valencian Kingdom, Northern Germany, and Southern Italy between the 15th and 16th centuries. The research endeavours to enhance our understanding of the geometric analysis, design, and construction techniques employed in these highly intricate vaults. While modern stone-cutting forms had yet to develop in Europe, a constructive and decorative technique that anticipated existing solutions in Western Christian culture had evolved in the Middle East. In this context, the study will progress by examining examples found in Eastern countries such as Armenia, Turkey, Israel and Egypt, which clearly exhibit construction similarities with Europe. Within this framework, the geometric analysis of five of the most complex vaults of the era will be conducted, and these vaults will be practically reconstructed. The existing knowledge has predominantly relied on sources and appears inconsistent in some aspects. The innovative approach of this project involves formulating hypotheses about vault design, supported by data obtained directly from constructed objects - a method not commonly used until now.  In this context, by comparing the current interpretations of existing sources with the results of field and workshop studies, it will be possible to examine similar structures based on a scientific foundation, thus allowing for the establishment of new connections between Christian Western and Muslim Eastern can be established through the history of construction. Furthermore, the research findings are expected to make a significant contribution to the preservation and restoration of cultural heritage.


**Keywords
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'LASER manipulation of PLASMONic nanostructures' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The ability of metal nanostructures to manipulate light at the nanoscale has resulted in an emerging research area called plasmonics. Plasmonics has developed into a rapidly maturing and broad research field, and it is progressively becoming an enabling technology for a number of forefront research areas like photovoltaics, chemical and biological sensing, medical therapy, information technology etc. However the fabrication of plasmonic devices is technically challenged because: there has not been developed yet a technique for precise control over the plasmon features, there is an engineering difficulty of delivering sharp nano-sized interfaces between metal and dielectrics, there is up to now no compatibility with large scale plasmonic applications and finally an experimental systematic study misses currently from the literature, which in turn provides a lack of feedback to technology for successful plasmonic large-scale applications. This proposal aims to address the hurdles mentioned above, through a wise implementation of a process technique that can be easily adopted by industry. This technique is Laser Annealing (LA), which can be a promising innovation in the field of plasmonics. The objectives of the present proposal are: 1. To develop and optimize seed materials for plasmonic nanostructures, 2. To identify the most appropriate LA system design and LA processing parameters, 3. To investigate the underlying mechanisms that govern the alteration of the NPs and their surrounding environment’s structure and opto-electronic properties, 4. To deliver the currently missing link between materials, deposition techniques and LA process parameters, by means of an experimental library that would facilitate the future development of plasmonic applications.""