RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targets for new antimicrobials directed to inhibit bacterial proliferation' (1994-1998).

assistant: **Concept**

Our objective is to define inhibitable targets in proteins required for bacterial proliferation. The molecular structure of these targets will be used by the industrial partners to design lead compounds to develop new chemotherapeutics, which are needed to overcome the rapidly increasing resistance of pathogenic microorganisms to classical antibiotics. The ability to effectively treat microbial infections will reduce morbidity, improve recovery from modern surgical techniques and generally positively impact on health management policies. Recently found protein-protein interactions between different components of the bacterial septation machinery offer new opportunities to design these novel antimicrobials. Targets will be sought in the proteins involved in the formation of the bacterial septum and in the assembly of the cell wall. Identification of the targets will be achieved by studying protein-protein interactions, defining the interacting domains and testing their ability to be inhibited by peptides and small compounds of known structure. Many of the proteins which form part of the septation machinery are encoded by genes which are conserved in disparate microorganisms. This phylogenetical conservation will be used to an advantage to design inhibitory compounds effective for a wide spectrum of microorganisms. This project aims at fulfilling the objectives stated in the Cell Factory Workprogramme which specifically read: development of molecular inhibitors capable of bypassing microbial resistance to antibiotics" (area 1.1.1, page 29 of the Workprogramme). We will develop inhibitory compounds which will reasonably yield one novel candidate drug for entry into development phase no later than 2 years after the completion of this project. Achievement of the objectives d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Continuous high-precision tall tower observations of greenhouse gases' (CHIOTTO) under Fifth Framework.

assistant: **Objectives**

The CHIOTTO-Infra project objective is to build an improved infrastructure for the continuous monitoring of the concentrations of greenhouse gases on the European continent above the surface layer using existing and new tall towers. This will be an important step towards a fully operational continuous observing system for the sources and sinks of the most important greenhouse gases (CO2, CH4, N2O, CO, SF6) over Europe and form the only independent tool for evaluating policy agreements such as the Kyoto protocol. We will integrate existing flux towers in the vicinity of the tall towers with the atmospheric stations network in a synergetic approach. We will carefully calibrate and monitor the inter-comparability of the concentration measurements between the institutes operating the air sampling networks. Quality controlled atmospheric concentrations. CO2 f1ux and additional meteorological data will be archived in a data centre accessible through the World Wide Web.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'One-chip low power transceiver for multi-mode portable phones' (OCMP) under Fourth Framework.

assistant: **Objectives**

The main objective of the OCMP project is to provide the market with a highly integrated low power transceiver chip, which addresses two modes of operation, DCS1800 and DECT, and can be used in future generation multi-mode terminals. The chip will contain high frequency bipolar circuits including frequency synthesizer components, up/down converting mixers, 900 phase shifters, LNA, etc.The direct conversion architecture will be adopted for the transceiver, thus allowing the maximum possible integration and, compared to the classical heterodyne approach, requiring fewer external components.A single mode DECT transceiver chip with direct conversion architecture will also be developed. This development, combined with existing partners' research results in a DCS1800 transceiver test chip development, will contribute to the definition of the multi-mode transceiver chip specifications. Compliance to DECT and DCS1800 modes will be demonstrated using the multi-mode transceiver chip in a multi-mode terminal demonstrator by verifying proper operation in each individual mode.The extension of the transceiver chip to the GSM standard will be studied.The OCMP project will apply proven analog low power design techniques to develop a single chip radio frontend for multi-mode (DCS1800 & DECT standards) hand portable terminal. It will include frequency synthesizer components, up/down converter blocks and amplifier blocks, such as LNA and prepower amplifier. The aim of the project is to prepare the way for the commercial availability of such an innovative component assisting significantly the small system companies which manufacture portable terminals and wish to enter the multi-mode terminal market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Closing the seed-dispersal loop: How does seed-dispersal affect plant population structure at the global, regional and local scales?' under Seventh Framework.

assistant: **Concept**

Seed-dispersal is an important ecosystem function with important consequences for the dynamics of plant and animal populations. This project will cover four related objectives which will evaluate different aspects of seed dispersal at the global (biogeographic), regional (national) and local (community) scales deepening the current knowledge on seed dispersal and its consequences. Early botanists identified sets of fruit-traits – i.e. dispersal syndromes – which improve the likelihood of propagules attaining seed-dispersal by specific dispersal mechanisms. Such syndromes have been at the centre of several important inferences regarding the long-distance dispersal of seed (LDD) and the colonization of new habitats by plants, although such inferences have been often speculative. By comparing the characteristics of the Azorean and the European floras, I will evaluate which, if any, syndrome has been favoured for the colonization of the Azores islands by plants. Simultaneously I will evaluate for the first time whether dispersal syndromes are a solid base to infer actual seed-dispersal mechanisms and thus colonization vectors for seeds. At a regional scale I will use historical data on plant and bird distributions in the UK and the Netherlands to determine the possible consequences of historical bird declines – and hence seed-dispersal – on plants bearing different dispersal syndromes. Finally I will be applying a complex-network approach at a local scale to evaluate the inter-year variability and estimating the effect of sampling effort on the main descriptors of seed-dispersal networks in a scenario of plant invasions in central Portugal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Certified Code Generation of Model-Based Modelica Controllers'.

assistant: **Concept**

In the Clean Sky consortium, several members are working on modelling and simulation of aircraft systems with the multi-domain modelling language Modelica. The final goal is to not only utilize these models for design and evaluation, but also to directly use Modelica controller models for generation of certified code in embedded systems. On one hand this will improve the system design process, since controllers developed in Modelica won’t need to be coded manually in a different language. On the other hand advanced nonlinear controllers could possibly be certified and thus applied on-board an aircraft.The objective of the CertMod project is to define the type of models and the Modelica 3.3 subset that shall be handled. This subset will be based on the discrete extensions of Modelica 3.3, including clocks and state machines. Once this subset is identified a prototype of a DO-178B Level A qualified code generator will be developed. This code generator will be an extension of the already existing SCADE Suite KCG code generator that has been qualified at Level A for DO-178B on numerous aircraft projects (Airbus A380, Boeing 787, etc.) by all civilian aeronautics certification authorities (FAA, EASA, etc.) . It will produce the C source code the controller that can be guaranteed to be a correct implementation of the input Modelica model. In order to do so, a preliminary phase will be added to KCG in order to perform a translation from the identified Modelica 3.3 subset into an intermediate form of KCG.Work will be performed to prototype the elements of the code generator that are necessary to qualify the tool. This includes traceability from the input Modelica model down to the C generated code, various types of specification and design documents, and a procedure to extensiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Policy options for responding to the growing challenge from obesity: a cross-national comparative study', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Abstract: The challenge of responding to the growing incidence of obesity will require not only improvements in sciences such as nutrition, it will also require socio-technical policy intelligence. A wide range of different kinds of interventions could use d to influence different aspects of the production and consumption of foods and levels of physical activity. No research has yet explored the consistency and/or variability of the perspectives of key stakeholders towards that range of options, nor have cro ss-national comparisons been made. This project aims to fill that gap. It would be premature to assume that a single uniform combination of policy options would be appropriate for both genders, all social groups or for all Member States. The Commission, Me mber States and many other stakeholders, would benefit from an improved understanding of how different kinds of interventions are perceived by differing groups of stakeholders. This project will use a new powerful technique (Multi- Criteria Mapping) to pro vide an integrative and comparative analysis of the differing perspectives of key stakeholders in 9 Member States on a broad range of possible types of interventions. The project's findings will contribute to identifying policy approaches that are most lik ely to be acceptable and effective at meeting this challenge.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Low capillary number flow in phase change porous media: permeability and liquid water capacity of snow.' (SnowMagnet), addressing dissemination and exploitation.

assistant: **Impact**

The effective hydraulic conductivity of snow is highly impacted by its microstructure, introducing a variability of at least three orders of magnitude, impacting seasonal flooding and glacier hydrology. Yet, the mechanisms of unsaturated flow and the impact of local phase transitions have never been investigated at the pore scale. This inhibits improving on the constitutive laws for larger scale models of snow hydrology using upscaling methods. Micro computer tomography is a very effective method for dry snow metamorphism but fails for wet snow because the transient flow and the accelerated change in microstructure cannot be resolved. We propose nuclear magnetic resonance (NMR) methods in combination with Lattice-Boltzmann simulations and Pore-Network models to characterize water flow in snow. Applying these methods on unsaturated flow in snow, we can resolve local saturation, liquid water displacement probabilities and diffusion measures, quantitatively measuring mechanisms of water transport. These are essential for gauging modelling approaches of transport phenomena. Whilst NMR methods have been used extensively on saturated flow, it has found limited application in unsaturated media and is poised for significant advances. To target melt and percolation phenomena in snow, we start with 3D printed porous media (single pores and fully resolved snow geometries) to refine the experimental setup and provide novel data for unsaturated flow in porous media. Assisted by Lattice-Boltzmann simulations we can link pore-scale mechanisms to the NMR data. The action will produce unique data sets on unsaturated flow as a function of capillary number in model porous media and snow. This data will be used to calibrate dynamic pore network models aiming at quantifying the transient fl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Centric Recipocating Compressor' (CR-Compressor) under Horizon 2020.

assistant: **Objectives**

Acknowledging that energy prices define competitiveness of many industries and compressors represent energy-hungry core manufacturing technology, Otechos aims to offer market leading energy-efficient compressor technology for industrial applications, being the natural choice for industries seeking environmental friendly solutions with low total cost of ownership.With a new, premium type industrial compressor (CRC) for air and gases, based on our patent pending Centric Reciprocating Technology (CR-T), we will disrupt the existing, fast growing market for industrial compressors by offering end-customers 30% less energy consumption than existing technology, yielding improved competitiveness through reduced total cost of ownership while offering substantial environmental benefits. It not only meets key purchasing criteria, it defines a new standard. By offering the CRC as core component in turnkey compressor solutions delivered by strategic partners, Otechos, with its entrepreneurial and competent management team, will draw strengths from existing market channels and international partnerships. Initial penetration will focus on CRC application in nitrogen production generators for marine and oil & gas. New partnerships, to be initiated in phase 1, will open up the global potential in the broader €25,6 billion (2020) compressor market offering a CAGR of 7,1%.  The P/L forecast shows a highly profitable business from year 3, following an investment of €2,3 mill and initial penetration of UK, Germany and Norway.As a bonus, the core technology CR-T has unique characteristics that makes it applicable in other areas as OTTO-type engines, pump technologies and gas / steam expander machines. Hence multiple business opportunities surface beyond compressor applications.  Phase 1 will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cellular Logistics: Form, Formation and Function of the Neuronal Microtubule Cytoskeleton' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The organization and dynamics of the MT (MT) cytoskeleton underlies the morphology, polarization and division of most cells. The structural polarity of MT determines the directionality of motor proteins, which move selectively towards either the MT plus (most kinesins) or minus end (dynein) to control the transport and positioning of proteins and organelles. Understanding how different cellular MT arrays, such as the mitotic spindle or neuronal MT networks, are built and utilized to ensure proper cellular logistics is a central challenge in cell biology. Recently, our lab has introduced a new technique, motor-PAINT, to directly resolve MT polarity and the relation between MT orientations, stability and modifications. This revealed that in neurons, the mixed polarity MT network in the dendrites is much more ordered than previously anticipated. MTs with opposite orientations have different properties and are preferred by distinct kinesins, revealing an architectural principle that could explain why different plus-end directed motors move towards distinct destinations. Nevertheless, the mechanisms by which this specialized organization is established and the different ways in which it modulates intracellular transport have remained unknown.To resolve how cytoskeletal organization guides transport, I propose to explore the form, formation and functioning of the neuronal MT cytoskeleton. We will combine advanced microscopy, molecular biology, and mathematical modelling to: 1) Create a complete 3D map of the dendritic MT cytoskeleton – form. 2) Unravel the mechanisms that establish MT organization in dendrites – formation. 3) Explore how specific MT configurations modulate intracellular transport – function.This research will uncover key mechanisms of cytoskeletal organizatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Liquefaction-proof design of houses: key insights and tools' (LiqproofHouses), addressing dissemination and exploitation.

assistant: **Impact**

Soil liquefaction during earthquakes has been a problem of great concern in earthquake engineering for more than half a century. Yet, many small-scale structures, such as low-rise houses, are still designed without consideration of the effect of liquefaction and have thus suffered extensive damage in several recent earthquakes. Liquefaction mitigation measures involving pile foundations or extensive ground improvement are expensive solutions for residential properties underlain by deep liquefiable deposits. Such structures can be more efficiently designed with partial-depth ground improvement, i.e. allowing limited extent of liquefaction at larger depths. This idea is less costly and more sensible for residential buildings, but it requires reliable assessment of the liquefaction response to ensure that any induced deformations can be well-tolerated by the structure. Also, this assessment should consider the entire range of earthquake loads occurring during the life of the structure. The proposed project aims to provide the means for such a holistic assessment of the liquefaction performance of low-rise buildings. Specific emphasis will be placed on quantification of ejecta-induced damage resulting from a discharge of liquefied soils at the ground surface. This quantification will be based on an integration of insights and data from nonlinear dynamic analyses, seismic centrifuge tests, and case-history observations. A procedure for estimating ejecta-induced settlement will be developed and used alongside existing shear-induced settlement models within a novel framework for holistic evaluation of the liquefaction performance. The key objective of this framework is to guide the design process by providing an in-depth understanding of the characteristics of the liquefaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Role of the nuclear receptor peroxisome proliferator-activated receptor alpha (ppar alpha) in regulating plasma levels of cardiovascular risk factors.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project aims at elucidating the role of the nuclear RECPTOR peroxisome proliferator-activated receptor alpha in suppressing inflammatory reactants such as fibrinogen and cytokines. We propose to study the regulatory mechanisms involved using transgenic mice models and adenovirus technology.