RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Generation and characterization of an in vivo model for LRRK2 mutations in Parkinsons Disease' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases, caused by degeneration of dopaminergic neurons in the substantia nigra. While the cause of the more frequent sporadic forms of PD remains unknown, the recent discovery of mutations in genes causing rare familial forms of PD provide a basis for better understanding of the molecular pathogenesis of the disease. One of these genes, LRRK2, encodes a protein with multiple predicted functional domains. Point mutations leading to auto somal-dominant PD have been found in all identified domains. Interestingly, mutations in the kinase domain of LRRK2 increase its (auto)kinase activity, inducing neuronal degeneration in cultured cells.  These results point to a gain of function phenotype l inked to these mutations, which is in line with the autosomal dominant feature of the known LRRK2 mutations in PD. In spite of this exciting recent progress, it remains unclear what aspects of LRRK2 function are relevant toward PD in vivo. Based on our cur rent knowledge we hypothesize that LRRK2 is a multifunctional protein that is an important regulator of the function of proteins central to PD. LRRK2 mutations interfere with this interaction, leading to degeneration of dopaminergic neurons in the substant ia nigra. To test this hypothesis, we propose to generate an in vivo model for PD linked LRRK2 mutations.  Using a state-of-the-art recombinase mediated cassette insertion method we will introduce specific LRRK2 mutations in mice. The strength of our approach is that we use minimal changes in the LRRK2 genetic locus, and it will allow us to study the effect of the mutation directly on its interaction with unknown proteins in the cells and tissue context that is relevant to the disease. We are confident that th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Next generation transparent solar windows based on customised integrated photovoltaics' (Solar-Win) targeting Horizon 2020.

assistant: **Abstract**

The main goal of Solar-Win is the industrial scale-up, validation under real-world operation conditions (TRL8) and commercialisation of next generation transparent and non-intrusive photovoltaic (PV) windows. The project will result in a unique transparent and electricity-generating window that merges the functionality of a PV module and a window in one, allowing a strong increase in the surface available in the building for generation of PV electricity. Solar-Win will revolutionize the Building Integrated PV (BIPV) and the architectural sectors, by providing a PV window solution featuring a unique set of characteristics, namely: (1) transparent and visually non-intrusive windows (with controlled visible transparency from 40% to 75%) able to generate up to 30 W/m2 of green electricity; (2) full compatibility with existing window manufacturing technologies; (3) lifespan equivalent to standard windows (20 years); and (4) cost effectiveness (cost increase of just 30% with respect to a standard window). To achieve these goals, solar-Win involves two Technology-based SMEs (PHYSEE and SUNPLUGGED from the Smart Window and PV sectors, respectively) coordinated by a flagship RTD organisation with a strong experience and background in technology transfer and optimisation of advanced PV technologies (IREC) and a leader constrution company (ACCIONA) which is the main costumer segment. The Project concept relies on the solar window patented technology developed by PHYSEE at TRL6, and on the highly flexible PV technology of SUNPLUGGED, which will be further optimised and customised for Solar-Win application. Solar-Win will overcome a major barrier that presently limits a further deployment of BIPV solutions, which relates to its intrusive character. Moreover, Solar-Win will allow ach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Internet Troubleshooting Service'.

assistant: **Concept**

Internet connectivity problems refer to events that cause an end-user to experience service interruption. They can be caused by equipment failures, routing misconfiguration, application-level errors, etc. Currently, Internet Service Providers (ISPs) and end-users have little ability to determine what caused a connectivity problem. In other word, the state of the art is wait and see". In this project, we propose to design an automatic and distributed troubleshooting service to diagnose connectivity problems in the Internet.This is essential for reducing the downtime of the Internet, and allowing the deployment of a new range of services such as delay-sensitive and mission-critical applications. First, we study the measurement infrastructure necessary for troubleshooting connectivity problems. This includes the use of passive and active measurements to identify the location of the connectivity problem. Then, we analyse the precision and accuracy of our inference methodology. Finally, we propose and prototype Trouble-shooter, a distributed troubleshooting service to assist end users and ISPs in identifying the location of connectivity problems."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Treatment od effluent coming from leather finishing industries' (1994-1998).

assistant: **Innovation**

The leather finishing process requires high water consumption that becomes considerably contaminated wastewater. The normal processes for treating this waste based on lime precipitation succeed in reducing tbe chemical oxygen demand , chromium, suspended solids and colour, but do not usually satisfy the regulation in force. Considering the inadequacy of the conventional processes to vironmental demands and aware of the growing scarceness of water, this has the prime objective of develop a waste treatment system that guarantees the environmental demands whilst saving water, by recycling it. The technolo that will be studied is the membrane processes (reverse osmosis and nanofiltration). By means of the membrane processes, all components present in the wastewater are retained, while high quality water pass through the membrane. In this way, two steams are obtained: a concentrate and high quality water, that is cycled back to the production process. So, the wastewater problem is solvedbut the concentrate must be treated or disposed off, because it is a toxic residue. Different alternatives like incineration, chemical oxidation and eleemical oxidation will be studied for the treatment of the concentrate. The oject consists of the following stages: basic studies, pilot and demonstration plant studies with synthetic and real wastewaters, and studies of the concentrate treatment .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SPATIAL ECOLOGY OF WHITE GRUBS IN AGRICULTURAL LANDSCAPES DOMINATED BY SUGARCANE: IMPLICATIONS FOR AREAWIDE PEST MANAGEMENT', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The research project addresses two major critical issues: the management of a group of major insect pests through better understanding of ecological processes involved in agrosystem-insect pest interactions, and the security of the world’s food and energy. The scientific purpose of the project is to assess the effect of landscape structure upon patterns of abundance and mobility of the Australian greyback canegrub Dermolepida albohirtum, the most devastating pest of the sugarcane ecosystems, to improve its control. It is particularly intended to examine how the pest uses a variety of landscape elements in relation to their availability. The research methodology will be based on 3 specific objectives: Quantifying landscape context in pilot sites; monitoring and mapping beetles movements and damage; data analysis and population modelling. To achieve these objective I will integrate the Australian private partner BSES that develop and use original research methods. The project will also offer me a unique opportunity to be trained in ecology and geostatitistics but also to better understand how a technology can be transferred to stakeholders. New tools such as radiotelemetry, Geographic Information Systems and simulation models will be combined to unravel the spatial ecology of D. albohirtum and to implement an areawide pest management initiative. The global aim of this fellowship is to reinforce the international dimension of my scientific career by consolidating my expertise in the field of spatial ecology of insects and to acquire new complementary skills to set up future projects with European and international institutions and industries. This fellowship has the potential to reinforce the expertise of Europe in pest risk analysis, this region being particularly exposed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ELectric Vehicle communication to Infrastructure, Road services and Electricity supply' (ELVIRE) under Seventh Framework.

assistant: **Objectives**

For E.V.s, the development of an interactive electric energy ICT & Service interface between the vehicle and its electricity infrastructure is of utmost importance, next to creating effective business models.<br/>The rationale of this project is to contribute significantly to neutralize the driver's range anxiety" and encourage the customers to embark the fully electric road transport.Therefore the objective of "ELVIRE" is to develop an on-board electric energy communication & service platform for realistic use-cases including the relevant external communication and services. For this purpose the following actions will be taken:\tselect representative use-cases according to realistic scenarios and business-models\tidentify & develop those off-board ICT & services needed to comply with the use cases\tdevelop "Prototypes" for the on-board Communication and E-energy service unit\tverify all integrated sub-systems  on prototype level and demonstrate the proof of concept.<br/>Great emphasis is placed on the "openness of the Electricity-service platform" granting access to multiple players maintaining the customers' choice.<br/>ELVIRE is structured into 5 work packages, with:\tWP 1000\tcovering the project administration, legal aspects and dissemination and  the inclusion of complementary RTD\tWP 2000\tdefines relevant mission data for the use case in consideration of technical and commercial aspects\tWP 3000\taddresses the external E-Service provision and the necessary E-IC instruments\tWP 4000 \tdevelops the e-communication device and the OEM-neutral universal on-board E-communication and service platform\tWP 5000  conducts integration and usability tests and the overall system validation.<br/>ELVIRE will become crucial to future electric road transport by closing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Elucidating the gene exchange networks of antibiotic resistance genes in clinical sewage microbiomes' (ARCS) under Horizon 2020.

assistant: **Objectives**

Antibiotics are essential for treating bacterial infections. However, antimicrobial resistance (AMR) has spread among pathogenic bacteria, leading to therapy failure or deaths of patients. Due to their association with promiscuous mobile genetic elements, clinically important antibiotic resistance genes (ARGs) can spread rapidly among diverse bacteria through horizontal gene transfer (HGT). Due to HGT, identifying the microbial hosts of the ARGs in an ecosystem is a challenge. Importantly, it has been shown that ARGS can spread from human gut commensals to clinical pathogens and vice versa. Wastewater from clinical sources can importantly select for HGT of ARGs between different microbes, as both antibiotics and ARGs are present at high levels. The aim of this project - ""ARCS"" (Antibiotic Resistance in Clinical Sewage microbiomes), is to reveal the ARGs exchange networks in clinical sewage microbiomes. The research objectives are: 1) Link ARGs to microbial hosts by using novel culture-independent methods based on DNA high-throughput sequencing. 2) Link ARGs to mobile genetic elements by isolating, sequencing, and characterizing the genomes of the identified hosts of ARGs. 3) Evaluate whether the isolates can transfer their ARGs to clinical pathogens using conjugation assays. ARGS will thus lead to a step-change in our understanding of HGT of ARGs in complex microbial ecosystems. The Fellow Dr. Lisandra Zepeda's expertise in generating and analysing DNA sequencing data and the host Prof. Willem van Schaik's international leadership in AMR ensure a successful completion of ARCS and a favourable knowledge transfer for both parties. Furthermore, the supportive environment of the University of Birmingham ensures the accomplishment of the Fellow's training in crucial areas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Intangible cultural heritage policies in Europe: what “participation” of which “communities”?' (ICHEUROPE) under Seventh Framework.

assistant: **Objectives**

« Participation » and « communities » are key concepts of the 2003 Unesco Convention for the safeguarding of intangible cultural heritage. This project investigates the current establishment of this heritage domain at the European level and compares how these concepts are interpreted in the implementation of the 2003 Convention in southern, central, and eastern European countries (Italy, France and Hungary). The project considers the impact of this new heritage paradigm both on national institutions (through an ethnography of institutions) and on local heritage stakeholders (through multisite ethnography). This project tests therefore a pioneering multisite and intersectorial approach which aims at promoting coordination of policy and action between all stakeholders (local, national and supranational). The goal of this comparative research is to provide EU policy makers with an analytical perspective capable of improving European interaction in the implementation of domestic and supranational heritage policies. The results of ICHEUROPE are intended to be transferred into applied social and economic intervention and have structuring effects on the actual implementation of EU heritage policies, allowing local stakeholders to establish collaborative safeguarding projects consistent with international regulations. This project addresses an uninvestigated domain and has therefore strong potential to stimulate further inter-sectorial research projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Management of Climatic Extreme Events in Lakes  Reservoirs for the Protection of Ecosystem Services' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Environmental perturbations to lakes and reservoirs occur largely as episodic climatic events.  These range from relatively short mixing events to storms and heat waves. While the driving events occur along a continuum of frequency and magnitude, however, their effect is generally longer lasting than the events themselves. In addition, the more extreme weather events are now becoming increasingly frequent, a trend that has been linked to directional climate change and is projected to continue in the coming decades. Understanding the impact of these short-lived pressures requires monitoring that captures the event (hours–days) and the ensuing impact, that can last for months or even years.  Only recently has automated high frequency monitoring (HFM) of lakes been adopted throughout Europe. This Training Network will investigate the effects of the most extreme events, and of cumulative lower magnitude events, using HFM, while at the same time training a cohort of doctoral students in state-of-the art technology, data analysis and modelling. The aim of the EJD is to change the way in which water quality monitoring is carried out so that the effects of episodic climatic events can be understood, thus ensuring that future water management strategies can explicitly account for their effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a unified speech processing strategy for combined electric and acoustic auditory stimulation' (BSPS).

assistant: **Concept**

Cochlear implants (CIs) can restore speech perception of deaf subjects by electrical stimulation of the auditory nerve. Because CI users sometimes perform better than severely hearing impaired subjects with a hearing aid (HA), implantation criteria are changing, leading to a steeply growing population of patients with a CI in one ear and residual hearing, used with a HA, in the other. This is called bimodal stimulation. Currently more than half of all newly implanted patients have residual hearing. Nevertheless, the CI and HA are fitted individually and their signal processors function independently. In this project, the fellow will develop a unified bimodal speech processing strategy. Its use can lead to improved sound quality, pitch perception, speech perception in noise, and sound source localization by combining existing techniques that enhance pitch perception in CIs with contralateral acoustic stimulation. The project is strongly multidisciplinary and balances on the edge between signal processing (engineering) and audiology (medical science). As the applicant has an engineering background and holds a PhD in the field of biomedical sciences, the project is a perfect match for his profile. Worldwide, research into bimodal hearing is concentrated in Australia and the US. There are no European labs that research it on a large scale. During the applicant's PhD, he started up bimodal research at ExpORL, KULeuven. Transfer of knowledge from Melbourne to ExpORL will allow him to further extend this line of research. He will set up collaborations with the Bionic Ear Institute, the University of Melbourne, Cochlear Melbourne and NAL. By gaining international experience, increasing his network and learning new research tools, after the fellowship, the researcher will fulfil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Eurocourse Integrity of Pressurised Components of Nuclear Power Plants""'.

assistant: **Objectives**

Due to restructuring of the electricity market and companies performing construction and maintenance work for NPP there is a need to enhance the qualification of young engineers and scientists entering the nuclear area or train engineers who change their area of expertise. Aim of the course on the integrity of pressurised components is to provide a comprehensive insight in basic elements on integrity analysis and assessment, to deepen the understanding of interdisciplinary nature of integrity assessment which involves all basic elements of definition of loads, structural analysis, material characterisation and manufacturing, non-destructive testing and surveillance methods including defect assessment. Supplementary presentations cover ongoing R&D activities and European and national codes and standards.