RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Structure Theorems for Modern Aspects of Geometric Measure Theory' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The aim of this research proposal is to develop the necessary theory of three areas of Geometric Measure Theory in order to solve several fundamental open questions. The origins of these questions can be found in recent advancements in various areas of modern analysis, such as the calculus of variations, harmonic analysis and geometric function theory, and differential geometry.The project will use and expand upon techniques recently pioneered by the PI. These techniques demonstrated the viability of geometric measure theory in arbitrary metric spaces. One focus of this project will be to continue with the natural progression of this research. The other focus will be to developing these techniques in order to solve seemingly unrelated problems in new areas of analysis. These methods have been successfully used to solve many well known questions, but it is clear that their full potential has yet to be realised.The main areas of interest are:(A): Fundamental questions regarding geometric measure theory in metric spaces.A central point of interest will be generalising classical characterisations of rectifiability to non-Euclidean settings.(B): Characterisations of quantitative rectifiability.The main goal is to prove a quantitative analogue to the Besicovitch--Federer projection theorem conjectured by David and Semmes.(C): The structure of currents.In particular, the project will follow a path towards solving the flat chain conjecture of Ambrosio--Kirchheim.Each of these areas concerns difficult yet important problems. As with other fundamental results of GMT, it is expected that these techniques will find applications far beyond their original purpose.


**Keywords:** Geometric measure theory, rectifiability, analysis on metric spaces, quantitative rectifiability, current
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Training European Experts in Multilevel Bioimaging, Analysis and Modelling of Vertebrate Development and Disease' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This proposal sprang from European scientists in both academia and industry who identified a common challenge: setting up a training frame to educate the next generation of imagers in complex biological systems (healthy & pathological), so they are able to master all major aspects of this competitive field and bring important innovations to universities and companies.The long-term goal of any initiative to image biological processes is reaching cellular or subcellular resolution in a complete organism. This is now possible using vertebrate embryos as models and the most recent technological advances as tools. ESRs will be trained by addressing the following scientific bottlenecks and challenges: -Preparing vertebrate embryos (rodent & zebrafish) for optimal imaging-Fine-tuning sensors, reporters and actuators to track cell types, cellular processes and behaviours in living organisms-Developing and implementing new imaging instruments-Analysing complex sets of big-data images to extract relevant information-Using processed images to design computational and mathematical models of development and pathologies-Comparing these models with experimental data and create a feedback loop improving the whole work chain from sample preparation to instrumentation and analysis.This interdisciplinary training is based on an intersectoral organisation of the consortium with partners from academia and companies that need these future experts to develop new instruments, screen drugs and chemicals in living systems and develop software to analyse and model medical images. The full training programme is based on an optimal balance between training through research and many network-wide training events, including conferences with physical presence, digital conferences and monthly videolink
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Magnet4Europe: Improving Mental Health and Wellbeing in the Health Care Workplace' (Magnet4Europe).

assistant: **Concept**

Over 23 million Europeans work in health care. Burnout, anxiety, sleep disorders, depression, and associated stigma are more common among health care workers, and exact a huge toll on individuals and families, particularly on women who are the majority of health care workers, and on society by erosion of productivity and safety of health services. Magnet4Europe transfers, modifies, scales up, and evaluates an evidence-based model of organizational redesign of clinical work environments to enhance workers’ wellbeing, retention, productivity, and patient outcomes. The Magnet model of workplace redesign has been adopted by 490 hospitals in 6 countries but has been slow to take root in Europe despite substantial interest as evidenced by letters from 84 European hospitals in 5 countries (Belgium, England, Germany, Ireland, Sweden) to participate in Magnet4Europe. Proof of concept of transferability of Magnet to differently organized and financed health care systems was shown in 2 pilots. Magnet4Europe modifies the Magnet model with stakeholder co-designed adaptations for Europe, one-to-one twinning with Magnet recognized hospitals, a learning collaborative including policymakers to promote success and sustainability, and a critical mass of institutions promoting innovation, attracting public interest, and fostering replication. Magnet4Europe uses a mixed method design to determine direct and indirect individual and collective health outcomes and cost effectiveness; it will improve mental health, reduce sickness absence, positively impact productivity and economic results by redesigned clinical work environments that promote mental health. The project will inform workplace mental health policies based on evidence with applicability beyond health care. Coordination is by exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Antigen-specific treatments to target autoimmune kidney diseases' under Horizon Europe.

assistant: **Concept**

Chronic kidney disease (CKD) affects around 10% of the population worldwide and is associated with significant overall and cardiovascular mortality. CKD is a heterogeneous group of disorders characterized by alterations in kidney structure and function and is progressive in nature. Autoimmune diseases are a common cause of CKD and responsible for its most aggressive and progressive forms, mainly in younger patients. Autoantibodies play major pathogenic roles in most of these disorders and multiple disease-specific target antigens have been identified  circumstances that have shifted treatment strategies from largely unspecific immunosuppression towards B and plasma cell-targeted therapies. However, such treatments still involve broad immunosuppression with potentially severe adverse effects. Hence, there is a huge gap between the increasing insights into the immune mechanisms and pathogenic role of autoantibodies against cellular antigens on the one side and the currently available treatments with limited specificity on the other side. The vision of AUTO-TARGET is the development and experimental implementation of pathogenesis-based and antigen-specific treatments for autoimmune diseases of the kidney. The objectives are (1) to identify and characterize novel molecular targets on autoantibody-secreting cells, (2) to target autoreactive B and plasma cells using nanobody-based compounds, and (3) to engineer chimeric autoantibody receptor NK and T cells for the treatment of different autoimmune diseases of the kidney. AUTO-TARGET thereby revolves around a highly translational approach, combining target identification and characterization in patients with autoimmune kidney diseases with unique in vitro and in vivo systems to model disease and validate therapeutics. These tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Data Infrastructure Ecosystem for Science'.

assistant: **Concept**

D4Science-II will develop technology to enable interoperation of diverse data e-Infrastructures that are running autonomously, thereby creating e-Infrastructure Ecosystems that can serve a significantly expanded set of communities dealing with multidisciplinary challenges whose solution is currently beyond reach. Furthermore, D4Science-II will bring together several scientific e-Infrastructures established in the areas of biodiversity, fishery resource management, high energy physics, etc., to set up a prototypical instance of such Ecosystem. This will support several critical scientific scenarios that are distinct but also feed into and enrich each other in nontrivial ways. Finally, possibly in collaboration with appropriate international bodies and initiatives, D4Science will take steps to ensure sustainability of the Ecosystem, some of them based on and synchronized with the dissemination, training and standardization activities of the project.Technologically, D4Science-II constitutes a continuation of the DILIGENT and D4Science projects, which have initiated an effort towards using existing network, grid, and repository infrastructures to deploy on top of them a pan-European research e-Infrastructure that will enable unlimited generation and dissemination of scientific knowledge. As the next step towards this goal, D4Science-II will transform the current, operational D4Science e-Infrastructure into the linchpin of an e-Infrastructure Ecosystem, holding together and mediating between all participating e-Infrastructures through programmatically-available interoperability services.The D4Science-II Ecosystem will include among others, the GENESI-DR and DRIVER repository e-Infrastructures, and important thematic repositories maintained by international organizations, e.g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'OPA1 in dominant optic atrophy' (OPA1) under Sixth Framework.

assistant: **Objectives**

The ultimate goal of this project is to identify the molecular mechanism underlying autosomal Dominant Optic Atrophy (DOA), a devastating genetic disorder leading to degeneration of retinal ganglion cells and childhood blindness.The gene defective in DOA maps to chromosome 3q28-29 and is called Optic Atrophy type 1 (OPA1). OPA1 encodes a mitochondrial GTPase which carries several mutations in humans with DOA. OPA1 is a mitochondrial protein involved in membrane fusion events that are required for mitochondrial integrity and maintenance. Loss of OPA1 function leads to mitochondrial fission, loss of mitochondrial DNA, and respiratory deficits.A decline in mitochondrial function is well recognized in neurodegenerative diseases and aging, and leads in the case of DOA to degeneration of optical neurons that result in blindness. The biochemical function of OPA1 is unknown. OPA1 is a 961 amino acid residue membrane protein that belongs to a family of highly conserved GTPases related to Dynamin.Intriguingly, the majority of missense mutations found in DOA patients reside in the highly conserved GTPase domain. In order to unravel the molecular mechanism behind DOA and to set the groundwork for the development of DOA therapies, a detailed understanding of OPA1 function is necessary. To achieve this, we plan a functional characterization of OPA1 by means of biochemical and structural studies.We have already established proof of concept with obtaining a purification protocol, preliminary functional characterization and initial crystallization conditions of OPA1. With funding of this proposal we will carry out a comprehensive functional characterization of OPA1 and shed light on its role in DOA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'OpenAIRE-Nexus Scholarly Communication Services for EOSC users'.

assistant: **Concept**

OpenAIRE-Nexus brings in Europe, EOSC and the world a set of services  to implement and accelerate Open Science. To embed in researchers workflows, making it easier for them to accept and uptake Open Science practices of openness and FAIRness. To give the tools to libraries,  research communities to make their content more visible and discoverable. To assist policy makers to better understand the environment and ramifications of Open Science into new incentives, scientific reward criteria, impact indicators, so as to increase research and innovation potential. To foster innovation, by providing SMEs with open data about scientific production. To this aim, OpenAIRE-Nexus onboards to the EOSC fourteen services, provided by public institutions, einfrastructures, and companies, structured in three portfolios: PUBLISH (catch all repository; Open Access overlay journal platform; data anonymization; Data Management Plans), MONITOR (Open Science and research impact monitoring; open citation indexes for article-article, article-dataset links; European monitoring of Article Processing Charges, publication usage statistics), and DISCOVER (open catalogue and APIs to the OpenAIRE Research Graph of interlinked publications, data, software, projects; discovery portals for communities; validation and brokering services for data sources to improve their metadata). The services are widely used in Europe and beyond and integrated in OpenAIRE-Nexus to assemble a uniform Open Science Scholarly Communication package for the EOSC. The project aims at forming synergies with other INFRAEOSC-07 awarded projects, the INFRAEOSC-03 project, research infrastructures, einfrastructures, and scholarly communication services define a common Open Science interoperability framework for the EOSC, to facili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Urban Chemical Threat Location and Identification' (UCTIL).

assistant: **Concept**

“Catch the bomb maker, not the bomb” reflects a paradigm change in security where threat detection methods allowing for preventive measures rather than localized checkpoint systems are deployed. The Brussels 2016 explosions, and recent use of military grade CWA in Salisbury UK have exposed vulnerabilities of our urban centers. Global terrorism, illicit drug distribution networks and foreign insurgent activities force governments to strengthen security measures to protect the population especially in metropolitan areas. We call this Urban Chemical Threat Identification and Location (UCTIL). Karsa intends to launch a product into the nascent UCTIL market by deploying a  sensor network that can continuously monitor ambient air for multiple target compounds with high sensitivity and specificity. The base technology already exists and has been proven robust for ambient and mobile measurements. Continuously monitoring ambient air in a complex urban environment for low concentrations of many chemicals stretches the limits of state-of-the-art technology. However, Karsa is extremely well positioned to address this challenge because it originates from the world-leading institute in atmospheric sciences (INAR) that has revolutionized the way chemical composition of the atmosphere is studied. We are seeking support to conduct a feasibility study to further explore this opportunity and prepare a plan to address R&D and business related activities to be undertaken in a potential phase 2 project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tin based anodic materials for new lithium-ion batteries', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content Objective: The design of new tin-based anodic materials with high capacity and performance for lithium-ion batteries. Activities: 1- Synthesis of electrode materials a) Anodic materials include crystallised and amorphous oxides (SnO2, Li2SnO3, Sn2BPO6, etc) and chalcogenides (SnS2, MSn2S4, etc). b) Cathode materials for advanced lithium- ion cells (LiMn204, LiCoO2, etc). 2- Structural and physical properties a) Chemical composition b) Crystal structure: X-ray diffraction (refinement methods). c) Local structure: environment of atoms, oxidation state, electronic structure (form FTIR, 6,7Li, 11B, 119Sn, HR-NMR and 119Sn Mvssbauer spectroscopy). 3- Electrochemical lithium insertion: intensiostatic and potensiostatic recordings. a) Definition of ranges of thermodynamic stability of inserted phases and structural changes. b) Evaluation of kinetic parameters as diffusion coefficients, enhancement factor and ionic conductivity. 4- Battery performance and optimisation Design and determination of the performance of test batteries directed towards an application to commercial batteries (non- aqueous electrolyte lithium anode and lithium-ion cells). Training content (objective, benefit and expected impact) Safety impact: by avoiding the use of pure lithium metal. Environment impact: appropriate energy storage system for clean renewable energies, without heavy metals (cadmium and lead). Expected scientific results:1. Synthesis of tin-based glasses.2. Characterisation of local order.3. Study of the lithium insertion properties.4. Preparation and evaluation of materials as cathode in lithium ion cells.5. Battery performance and optimisation Links with industry / industrial relevance (22) The laboratory of Cordoba collaborates since some years ago with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Enhanced Satellite Laser Ranging System'.

assistant: **Objectives**

The EO-SLR is a next generation satellite laser ranging system that incorporates latest advances in the field to assure ease of setup, use and sustainable economic operation. Packaged in standard sea container with modular design for laser systems, climate control, calibration equipment, data systems, and power systems it can be made operational with manufacturer settings within days and is potentially mobile.The EO-SLR is being designed to address the rapid growth in the number of objects in space that must be tracked. Google and other private firms are planning to launch hundreds of satellites. The Cubesat revolution has opened space to public and private sector of smaller or less technically developed countries, their universities, research institutes and even private SMEs. Simultaneously problem of space debris is an increasing global public concern. The International Laser Ranging Service has identified geographic market gaps, lack of standard components, absence of next generation equipment and other concerns. The EO-SLR is being designed to meet those needs with a packaged system with new features and functionality unmatched by systems in the market:•Data for space object orbit calculations from one observation site •Improved ranging accuracy of scattered light space objects including closely located (groups of) space objects•Advanced calibration and testing system, that significantly speeds up the measurement process •Easily convertibleHighly complex products like SLR systems demand a broad range of multidisciplinary skills to design. HEE Photonic Labs emerged from the research center of the University of Latvia that had developed SLR systems and other advanced equipment for the Soviet space program from 1970-ties.This is an substantial advantage allowing to des