RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unrevealing the mechanisms involved when producing biodiesel from waste oil using a combined experimental and theoretical methodology' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

40% reduction on emissions should be achieved by 2030 within EU with the outstanding goal for Europe to become the first climate neutral continent by 2050. These goals need to be reached without jeopardizing economic development and growth, and simultaneously fulfilling the UN goals for sustainability.One of the main contributors to climate change and global warming is emissions from our vehicles as these mainly use petroleum-based fuels. To address this, new approaches, methodologies, and technologies must be developed.Biodiesel is one option to substitute diesel; however, its production has been controversial since it requires the use of edible oils and thus creates conflicts with the production of food crops, making it less attractive. Because of this problem, newer technologies are being developed to treat lower quality nonedible oils. However, as yet, these are not economically viable.To address these problems, UNPRECEDENTED will focus on the use of waste oil. This new raw material has been tested experimentally with promising results. However, how the reaction is taking place and the steps involved is far from being understood. This lack of knowledge has a negative effect when selecting new technologies or testing new feedstocks. UNPRECEDENTED will use a combine methodology of experimental data and theoretical modelling (DFT based calculations) to study and fully comprehend the biodiesel production reaction. This methodology will permit a full understanding of the reactive steps involved, the reaction pathway that is followed as well as the energies involved in each reactive step. This methodology will assess for the conversion of waste oil in the presence of renewable alcohols to produce biodiesel when using new catalytic materials that are biobased, produce from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Preparation and development of a chamber detector suited for ultralow radioactivity measurements in biological and medical fields'.

assistant: **Innovation**

This research project is submitted in view of developing a new generation of particle detector for measuring the activity of ultra low energy isotopes. The final applications for this detector are autoradiography and medical imaging which will result in a large reduction (between 20 and 200 times) of the radioactive doses currently used in these domains. The principle of the detector is based on a high efficiency chamber that would be able to count at a level of 5 megahertz, allowing rapid quantification and measurements and leading for instance to real-time imaging of the heart after injection of an isotope. Our goal is to manufacture and market worldwide precision measurement instruments detecting low dose isotope for use in the biological and medical domains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ecological and economical development of innovative strategy and process for clean maintenance and dismantling further recycling of vehicle parts' in the context of a Sixth Framework call.

assistant: **Objectives**

To achieve objectives of End of Life Vehicle directive (ELV), the automotive industry and its suppliers need tointegrate at design stage of next generation of vehicles, innovative processes and methodologies that will beused for maintenance, dismantling and recycling of car elements.Today, the automotive industry suffers from alack of solutions that could combine cost-effectiveness, quickness, low energy consumption and selectivity formaintenance, dismantling and recycling of materials such as plastic, composite, glazing, metals and aluminiumparts, which are used more and more. The objective of ECODIS project is to provide to the automotive industryecologie and economic processes to oversome these difficulties and improve its competitiveness. This will bedone through the integration of active systems within adhesives that are expandable when exposing them to anexternal energy source. To develop processes for debonding operations, the partners will focus their efforts on :-Specifications of a wide range of active systems, type, temperature sensitivity range and coating preventingdegradation-Range and type of suitable energy sources, infrared, UV and electrical.- All technology experimentalresults and best options for each interface.-Computer mathematical model identifying the most suitablemicrospheres with the trigger options to match the adhesive and materials to be bonded and de-bonded.-Computer mathematical model identifying the most suitable active systems with the trigger options for theapplication of curing to match the adhesive and the materials to be bonded.- Processes and methods to usethese materials for debonding operationsd during maintenance and dismantling operations.The consortiumgathers 12 partners from 7 EU countries (6 EU countries and CH) and includes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Immunomodulatory effects of sustained pantethine release in inflammatory diseases'.

assistant: **Concept**

Auto-immune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) and inflammation-associated brain diseases including Alzheimer's disease (AD) globally make up a €45B market and cost society close to €648B. The huge number of patients with these diseases causes an enormous socioeconomic burden. Currently, MS, AD and RA affect 120M people worldwide. There is no cure for AD and treatments for autoimmune diseases are not fully effective and reducing the inflammatory component in these diseases is a key strategy.As a result of our ERC StG NEUROTRAFFICKING we found that a natural molecule, which is Coenzyme A precursor (CoAP), modulates leukocyte trafficking and has anti-inflammatory properties that are, however, limited in effectiveness due to fast breakdown in the gut. Our preliminary data demonstrate that derivatives of CoAP hydrolysis are devoid of antiinflammatory effects and that intact CoAP is required for its therapeutic effect in mouse models of MS and AD. The goal of IMPEDE is to develop a proprietary formulation of CoAP that protects it from hydrolysis and its disulphide bonds from degradation. This provides a novel and highly promising therapeutic approach for the inflammatory diseases, either for combination or stand-alone treatment. A patent application for this novel CoAP formulation has been filed. Subsequent steps will be taken in IMPEDE to generate and validate a more effective product through improved formulation and to prepare further regulatory and IP strategies, design a business strategyand perform market research. Overall, IMPEDE offers a rapid valorisation of the ERC StG grant on one hand and of the novel CoAP formulation on the other hand. It will generate a novel CoAP formulation with high therapeutic potential in autoimmune disea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Unique Research Asset for Nuclear Innovative Applications'.

assistant: **Objectives**

Materials response to harsh irradiation, temperature and corrosive media is preventing the successful exploitation of innovative nuclear fusion, advanced fission technologies for sustainable energy production and human exploration of faraway planets. Specifically, materials degradation and early failures hinder these scientific longstanding endeavours. The current paradigm to tackle these issues is to implement mitigating solutions or to characterise the surrounding environment to understand failure initiation and propagation.URÅNIA shifts this approach by focusing directly on understanding the incubation stage prior to initiation events. In this view, I will: i) create a novel gold standard to reveal the incubation stage of materials degradation phenomena; ii) reveal precursors affecting the transition from incubation to initiation, iii) link precursors nanoscale effect to macroscopic degradation behaviour. I want to accelerate the development of innovative nuclear technologies thanks to a new approach towards materials degradation investigation leveraging a combination of hierarchical analyses and interdisciplinary competences across nuclear, chemistry, materials science and engineering. URÅNIA ground breaking idea is to: 1. Create a system where I can measure time to initiation in controlled stress corrosion cracking (SCC) and pyrophoricity experiments. 2. Freeze at specific instants the incubation to initiation transition. 3. Reveal precursors using isotopic tracers with advanced microscopy. 4. Link precursors role at the nanoscale to the resulting macroscale effect using a neural network tool. 5. Compare precursors role in unirradiated and irradiated materials to elucidate the reasons for potentially enhanced SCC. URÅNIA changes the approach to investigate material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'unveilinG cEll-cell fusioN mEdiated by fuSexins In chordateS' in the context of a Horizon 2020 call.

assistant: **Objectives**

Membrane fusion is essential for many physiological and pathological processes: infection of enveloped viruses, fertilization, intracellular trafficking of vesicles and in some cases of organogenesis. These processes are mediated by specific proteins called fusogens. Fusexins are fusogens that are essential for sexual reproduction and exoplasmic merger of plasma membranes in protists, plants, invertebrates and class II enveloped viruses. The main goal of my project is to characterize the least understood class of membrane fusion: cell-cell fusion processes within the phylum Chordata mediated by proteins from the Fusexin superfamily. I will evaluate whether proteins from mouse gametes with predicted structural similarities to Fusexins fulfill the two criteria to be considered fusogens (i.e. necessity and sufficiency for membrane fusion). In parallel, I will elucidate the mechanisms of action of the amphioxus Br-FF-1 proteins, the first Fusexins described in Chordata. The project involves both high risk and feasible objectives, employing assays that are well established in the Podbilewicz lab as well as the development of new techniques (including in vitro fertilization assays, fusion in heterologous cells, pseudotyping of viruses and virus-cell infection). I expect that results obtained will shed light on the evolution of the Fusexin superfamily that maps to the beginning of the eukaryotic cells and enveloped viruses, and thoroughly characterize the mechanisms of action of cell-cell fusogens. My proposal has the potential to lead to breakthroughs in understanding and manipulating membrane fusion in sexual reproduction, organ development, diseases and tissue repair.


**Keywords:** Fusion, Fertilization, Sperm, Egg, Membranes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Carbonic anhydrase: where the CO2, COS and H2O cycles meet""', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Quantifying the carbon storage potential of terrestrial ecosystems and its sensitivity to climate change relies on our ability to obtain observational constraints on photosynthesis and respiration at large scales. Photosynthesis (GPP), the largest CO2 flux from the land surface, is currently estimated with considerable uncertainty. A recent estimate of global GPP was based on an atmospheric budget of the oxygen isotope composition (d18O) of atmospheric CO2 that strongly relies on the oxygen isotope exchange rates with leaf and soil water pools. This isotopic exchange is rapidly catalysed by carbonic anhydrase (CA) in leaves and to a lesser extent in soils. Soil CA activity was neglected in global CO18O studies until the project PI showed recently that CA activity in soils played an important role for determining the magnitude of global GPP using CO18O. The overall goal of SOLCA is to understand better the environmental and ecological causes behind the variability in CA activity observed in soils. A first hypothesis is that soil CA activity responds to thermal and osmotic stresses. This will be tested by probing CA activity of soil monoliths from around the world using a non-invasive gas exchange technique developed by the PI. Because probing soil CA activity from CO18O gas exchange data requires a knowledge of the d18O of soil water and CO2 diffusion processes, we will utilise additional tracers of CA activity: CO17O and carbonyl sulphide (COS) that will also be measured as they follow the same diffusional pathway as CO2 and are also taken up by CA. A second hypothesis is that soil CA activity can be predicted knowing only global indices of the soil microbial community. This will be tested using state-of-the-art molecular techniques to explain changes in CA activity lev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ancient viruses in thawing permafrost: who are they and how do they impact present-day ecosystems?' (PermAVirThaw) under Horizon 2020.

assistant: **Objectives**

Around 17% of the Earth’s terrestrial surface is composed of permafrost, characterized by frozen ground for at least two consecutive years. Humanity has left Pandora's freezer door open⁠. With the poles warming 3-times faster than the rest of the world, permafrost is being rapidly lost, potentially releasing ancient microbes locked in frozen soil. Accumulated evidences show that microbes, including viruses, locked in ancient permafrost can stay viable over millennia. However, little is known about viruses that froze alongside many of these microbial communities, and their release due to permafrost thaw may directly affect the population dynamics of present-day hosts. To understand these impacts, we need to determine which viruses are archived in permafrost and which hosts they can infect. Viruses infecting plants and animals might pose major economic and human health threats whereas viruses infecting microbes can transform ecological systems on which we rely. Therefore, the Fellowship goals are i) to determine how the virosphere varies with permafrost age and type across the Arctic; ii) to quantify the capacity of virions extracted from permafrost to infect present-day microbes; and  iii) to measure the impact of permafrost extracted virions on present-day microbial community diversity and carbon cycling.  The main outcomes will be large-scale knowledge on the composition of the ancient permafrost virosphere and the influence of age (including palaeoenvironment) on virus persistence and diversity, as well as their capacity to infect present-day microbes and change biogeochemical cycles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nas complement to contract number grd1 ct 2000-00389; high performance rail tracks (HIPERTRACK)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The NAS complement proposal focuses on the investigation of determinants to describe the efficiency of materials used for track systems and the demonstration of achieved improvements by means of experimental investigations and the tests results obtained with the prototype high speed track system HIPERTRACK". The behaviour of the track system will be worked out with the view of rolling contact fatigue of the rail material."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sharing and Automation for Privacy Preserving Attack Neutralization' (SAPPAN), addressing dissemination and exploitation.

assistant: **Impact**

SAPPAN aims to develop a platform for sharing and automation to enable privacy preserving and efficient response and recovery utilizing advanced data analysis and machine learning. SAPPAN will provide a cyber threat intelligence system that decreases the effort required by a security analyst to find optimal responses to and ways to recover from an attack. SAPPAN will enable this within a single organization as well as across organisations through novel models for privacy-preserving data processing and sharing. It will enable utilizing external experts for intrusion detection and sharing of knowledge on response and recovery actions while respecting the privacy and confidentiality requirements of individuals and organizations. SAPPAN will enable a European level perspective on advanced cyber security threats detection, response, and recovery making four key contributions that go beyond existing approaches: (1) privacy-preserving aggregation and data analytics including advanced client-side abstractions; (2) federated threat detection based on sharing of anonymised data and sharing of trained machine learning models; (3) standardisation of knowledge in the context of incident response and recovery to enable reuse and sharing; (4) visual, interactive support for Security Operation Center operators. SAPPAN aims to provide solutions for public international institutions and multinational companies who want to enrich their Situational Awareness by sharing cyber security intelligence as well as solutions  for small and midsize companies enabling them to outsource intrusion detection. SAPPAN will be demonstrated in the relevant environments of 2 multinational companies, 1 National Research and Education Network (NREN) and 2 Computer Security Incident Response Teams (CSIRT). The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Coupling laser spectroscopy to mass spectrometry and ion mobility: from fundamentals to analytical sciences' in the context of a Seventh Framework call.

assistant: **Objectives**

The motivations for studying the gaseous structures of peptides and proteins range from developing efficient methodologies for protein identification and quantification to fundamental understanding of folding processes and biomolecular architectures. Mass spectrometry allows analyzing biomolecular ions in a variety of different forms, for example, as a function of charge state, bound to their targets or in multimers following aggregation. Ion mobility-mass spectrometry is a revolutionary technique regarding the separation of complex mixtures and structural isomers and can now play an important role in the study of protein shapes and their complexes. In parallel, optical spectroscopy is also emerging as a key element in gas phase methods available for investigating biomolecular ions. In this proposal, we want to combine spectroscopic approaches with high resolution mass spectrometry and ion mobility to widen and deepen the scope of mass spectrometry in its various fields of applications including structural biology, protein identification and quantification. The general idea behind our approach is to simultaneously obtain “orthogonal” information on gas phase molecular conformation from ion mobility and optical spectroscopy, with in addition the possibility of using light to induce conformational changes or the formation of new species. A goal of this cross-disciplinary proposal is to study the structural reorganization of proteins occurring in relation to aggregation, radical formation and oxidation, focusing on misfolding and the earliest stages of tau protein assembly. Moreover, fundamental understanding of structure and reactivity of peptides and proteins will serve as a lever for the development of applications in analytical sciences using photon based dissociation.