RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Regulation of gene expression and cell fate by DNA (hydroxy)methylation'.

assistant: **Innovation**

(Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development. These modifications are considered to be epigenetic marks, since they have a profound impact on phenotype, but are inherited from mother to daughter cells independent of the underlying DNA sequence. Large efforts are currently underway to profile genome-wide DNA (hydroxy)methylation patterns in model organisms and in clinical studies, since aberrant DNA (hydroxy)methylation is a hallmark of cancer. Strikingly, the molecular mechanisms underlying the link between DNA (hydroxy)methylation and gene expression remain elusive. Although causal links are thought to arise from differential recruitment of transcription factors to (hydroxy)methylated DNA in a regulated manner during development, technical limitations have thus far prevented unbiased interaction screenings to investigate this hypothesis in detail. By using a unique combination of state-of-the-art quantitative mass spectrometry-based proteomics technology, genomics approaches and biochemical experiments, I will systematically investigate which proteins interact with or are repelled by (hydroxy)methylated DNA during stem cell differentiation into a neuronal lineage. Furthermore, I will investigate whether and to what extent these interactions regulate gene expression programs and lineage commitment. The results of these studies will reveal the mechanisms through which dynamic DNA (hydroxy)methylation patterns dictate cellular responses. This is anticipated to significantly increase our understanding of eukaryotic development and the role of epigenetics herein. Furthermore, these studies will pave the way for designing strategies aimed at interfering with altered epigenetics patterns in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Consumers Leading the EU’s Energy Ambition Response, Expansion' (CLEAR-X) targeting Horizon 2020.

assistant: **Abstract**

CLEAR-X - Consumers Leading the EU’s Energy Ambition Response, Expansion - is an ambitious extension of a tried-and-tested methodology, designed and developed to address consumers’ needs. The overall objective is to enable consumers to lead the energy transition by investing in renewable energy and sustainable energy (RES) and energy efficient (EE) technologies. It aims to facilitate consumers’ access to household renewables at an affordable price, through the provision of trusted information, collective purchase schemes and an improved regulatory framework. By the conclusion of CLEAR-X, consumers will have improved the energy performance and comfort of their homes and reduced their energy bills in the long term. The CLEAR-X project will engage 38,000 consumers in collective purchase campaigns in 6 target countries and will trigger over 27M EUR in installations of RES technologies. The project is expected to result in an additional 40 GWh of renewable energy production and trigger 2.15 GWh of primary energy savings within the project duration. Furthermore, the project will help inform a significant number of consumers in the target countries about potential benefits of EE and RES technologies and influence an additional 17,000 consumers to act and save energy. Building on CLEAR (Intelligent Energy Europe) and CLEAR 2.0 (Horizon 2020), CLEAR-X will expand the proven collective purchase model, by engaging and supporting consumer organisations in Eastern and Southern Europe to launch schemes for their national consumers. Consumer organisations participating in CLEAR 2.0 developed considerable expertise in setting up and running collective purchase schemes and CLEAR-X will draw on this experience, both human and technological, to equip consumer organisations in the target c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Kinetics and Dynamics at Surfaces'.

assistant: **Concept**

This proposal implements slice imaging to measure catalytic rates for site-specific elementary reactions thus offering remarkable opportunities to advance our fundamental understanding of heterogeneous catalysis.  As evidence for global climate change continues to grow, catalysis has moved to the front line of the struggle to obtain new, sustainable technologies for the future.  Catalysis and catalytic processes account, directly or indirectly, for 20-30 % of world Gross Domestic Product.  Knowledge of elementary chemical reaction mechanisms in heterogeneous catalysis underlies our ability to construct comprehensive kinetic models for many such important chemical processes, in order to optimise them.  Our proposed strategy makes the formidable task of describing site-specific chemical reaction mechanisms and elementary rates in heterogeneous catalysis facile, while its necessity we justified (Nature 2018) on the prototypical CO oxidation reaction on Pt by demonstrating that 40 years of traditional experimentation led to false interpretation of the reaction mechanism. The aim of this proposal is characterize the important factors that influence the kinetics of elementary reactions at surfaces, e.g. the chemical nature of the catalyst and the geometry of the active site (stereodynamics). We chose elementary reactions involving C, H, O, N, as these are important in many key industries, such as the methane reforming, syngas, fuel cells, Fischer-Tropsch synthesis and the Haber-Bosch process.  Our strategy is that of a “bottoms up” approach to catalysis, i.e., building and understanding complex heterogeneous chemical catalysis, from the site-specific kinetics of the elementary building block reactions.   Our measurements, will serve for benchmarking first principles calculati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ion Transport Proteins in Control of Cancer Cell Behaviour' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

With over 3 million new cases and 1.5 million arising deaths each year in Europe, cancer is a major public health problem with an urgent need for new therapies. This proposal builds upon mounting evidence that ion channels and transporters underlie many of the hallmarks of cancer. Thus, proteins involved in membrane transport, long known as important drug targets in other pathologies (channelopathies), are a new class of therapeutic and/or diagnostic targets in oncology. IonTraC is first to propose a systematic analysis of the expression, function, as well as therapeutic and diagnostic potential of proteins involved in ion transport (the ""transportome"") in cancer. This paradigm will be implemented in pancreatic ductal adenocarcinoma (PDAC) which has one of the worst prognoses of all cancers, with an overall 5-year survival rate of less than 5%.IonTraC thereby provides the framework for an inter- and supra-disciplinary training for early stage researchers in a highly innovative, exponentially growing field in oncology which will have a major impact on other disciplines such as immunology and angiology as well.The main objectives of IonTraC are:•to provide a scientific and methodological platform for supra-disciplinary training of early stage researchers in and beyond the fields of ion transport and oncology•to provide an inter-sectoral training programme with special focus on career development of young researchers•to determine the concerted expression and function of ion channels and transporters required for the progression of PDAC, and•to provide validated therapeutic and diagnostic concepts and tools that are based on transport proteins serving as novel drug targets and/or biomarkers.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Genetic component of the low dose risk of thyroid cancer' to be submitted under Sixth Framework.

assistant: **Abstract**

Cancer of the non-medullary (follicular epithelium) component of the thyroid is induced by external irradiation and by radionuclides deposited within the thyroid tissues. Estimates of the radiological risk of developing thyroid cancer are derived from epidemiological studies performed in populations receiving high doses. Extrapolation of this risk to exposures at much lower doses is compromised by the lack of an accurate model of the dose response curve for thyroid cancer at low doses. Moreover, such population-based estimates fail to take into account the contribution of individual genetic variability to the risk estimate. Individuals with an increased genetic predisposition to develop thyroid cancer are not identified, and it is precisely these individuals who will be at greatest risk at low doses. The GENRISK-T consortium is composed of thyroid cancer experts with experience in the fields of radiation biology, animal models of radiation-induced cancer, tumour banking, cancer biology, molecular genetics, histopathology, cytogenetics and risk modelling. We will use this interdisciplinary knowledge to define the genetic component influencing the risk of radiation-induced thyroid cancer. This will be achieved through a combination of studies using animal models and in human radiation-induced thyroid tumours. This new understanding of genetic risk modifiers will be used to develop an animal model of thyroid cancer that is responsive to low dose radiation in the cGy range, thereby providing an experimental solution to resolving the uncertainties of the low dose response curve.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PhD excellence program in Paris-Saclay to unravel AI uncertainty' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Artificial intelligence is a pervasive and ubiquitous technology, with fast developments and ever-growing applicative horizons. While achieving outstanding results, estimating the decisions’ reliability is a critical and open problem with strategic outcomes: from estimating uncertainty in numerical simulations to harnessing system reactions in open environments. Uncertainties both in input data and model output should be handled to increase the confidence in AI applications : physics-based models, edge computing, data frugal approaches, interactions with humans, with many applications in energy, climate change adaptation, bioinformatics, engineering, fundamental and material science,… DeMythif.IA is an international doctoral training and career development program driven by UPSaclay, and its 19 research and industrial partners supported by thematic networks to enhance the scientific excellence and career development of 30 PhD fellows in Greater Paris area. The program focuses on 3 interdisciplinary scientific axes 1) handling uncertainties on data and model and quantifying uncertainties on the predictions, 2) managing explainability, so that the trained model outcome can be trusted and explained to a human, and 3) encouraging frugality, both in term of labelled data and energy for training, so that real-life applications (as opposed to proofs-of-concept) emerge. The fellows will benefit from world-class scientific programs, quality supervision and industrial secondments and also from personalized career development activities and transferable skills training (interpersonal, communication, digital, entrepreneurship, open science, gender, ethics). DeMythif.AI’s strength lies in its diversity permitting to fine-tune the content offered to the fellows from a professional pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'LIght for controlling Reactive Interactions in COld molecules'.

assistant: **Innovation**

Ultracold molecules are the next frontier of quantum technologies: their rich internal structure and tunable long-range interactions enable the exploration of new regimes, unattainable with atomic platforms. Achieving this control requires cooling to ultracold temperatures. However, ultracold molecular interactions are dominated by lossy chemical reactions. Chemical reactions hamper the quantum applications of molecular gases and our strategies to reach the ultracold temperature limit, including the realization of the holy grail of ultracold molecular physics: a Bose-Einstein Condensate of polar molecules. Recently, I successfully developed several shielding mechanisms to protect polar molecules from chemical reactions and exploited them to realize the first quantum degenerate Fermi gas of molecules by direct evaporation. In LIRICO, I will leverage on these previous results to control the chemical reactions of ultracold molecules and thus unlock the full potential of molecular quantum gases. A high-finesse optical cavity will be the fulcrum of LIRICO to tame chemical reactions. Strong light-molecule coupling will create new hybrid light-molecule states, so called molecular polaritons, that will display the ability to turn on-and-off a chemical reaction by simply controlling the molecule-cavity resonance. The addition of final-state sensitive detection methods, such as an ion-mass spectrometer, will allow to fully resolve the microscopic mechanisms that underpin ultracold reactions. I will steer the reaction dynamics at will and control the reaction product distribution with the cavity vacuum, thus realizing a paradigm-changing, fully quantum-mechanical catalysis method for controlling the transformation of molecular materials. Cavity-control of ultracold chemical reacti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Adaptive Digital Systems for Sustainable Construction and Material Management in the Circular Economy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

ADAPT4CE is an innovative initiative aimed at revolutionizing the construction sector's approach to sustainability and resource efficiency. The project focuses on sustainable deconstruction and material reuse through advanced digital technologies such as artificial intelligence, machine learning, augmented reality, additive manufacturing (AM), blockchain, and the Internet of Things. A primary goal of ADAPT4CE is to create expert systems for precise material characterization, to improve traceability with RFID technology, and to establish localized material banks for effective resource reuse. By developing digital tools for informed deconstruction decision-making, the project seeks to implement circular economy principles, optimize the use of resources, and ensure environmental sustainability in construction practices. Key activities include the development of computational algorithms for structural optimization, integration of Design for Disassembly principles into Building Information Modeling tools, and the conduction of life cycle assessments for construction materials to promote sustainable design practices and reduce environmental impacts. The project exploits advanced AM techniques to enhance the adaptability, durability, and sustainability of construction materials. By identifying smart materials with self-healing properties and furthering the capabilities of 3D/4D printing technologies, ADAPT4CE aims to transform the industry standards and benchmark new manufacturing methods against traditional practices. A centralized digital platform is being developed to integrate BIM, databases, and digital tools to support the entire lifecycle management of construction projects. This platform will facilitate predictive maintenance through digital twin technology, ensure dyn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'New combustion systems for gas turbines (NGT)'.

assistant: **Concept**

Objectives and Problems to be solved:The objective of this project is to show that the new combustion systems FLOX(r) and COSTAIR are economically and ecologically more efficient than the premixed combustion systems currently used in gas turbines. The following main improvements are sought:· Elimination of pulsation in gas turbine combustion chambers· Increase in the combustion stability in a wide range of excess air ratio · Suppression of high pollutant emissions in the part load operating mode* Increase in the efficiency of gas turbine systems * Replacement of premix burners by the new combustion technology Description of the work: In order to achieve the objectives, the FLOX(r) and COSTAIR combustion systems will be investigated in depth. Their advantages will be defined, quantified and used to modify existing burners or to design a new generation of burners .The advantages of the new systems will be evaluated at two test rigs at the end of the project. The tools to achieve these results will be experimental investigations at the relevant pressure levels and associated CFD simulation work, fundamental studies and model enhancements as well as process and combustion chamber design by the manufacturers involved. The main steps will be as follows:· Experimental and mathematical investigations under atmospheric pressure- Burner and combustion chamber modifications for the operation under gas turbine conditions- Mathematical modelling of the modified burners- Tests of the modified burners under gas turbine conditions - Tests of reliable operation at gas turbine test rigs Expected results and exploitation plans: Expected major results are:- safe and reliable operation of gas turbines by improving the stability of the combustion process and the avoidance of flame flash back
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Green-Tech Fibre Insulation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Miljøskærm is a Danish SME having independently developed an innovative concept and solution for recycling of discarded wind turbine blades and developed products applying the recycled material as acoustic absorbent material in noise barriers and for thermal insulation purposes.Today, more than 95% of discarded wind turbine blades and other composite materials go to landfill with significant negative environmental and economic impacts. On a global scale it is estimated that 400.000 tonnes of blades alone will reach their end-of-service life during the period of 2020-2030. Our solution comprises development of purpose-built technology for processing of end-of-life wind turbine blades to produce a glass fibre granulate and applying this in products meeting specified requirements for acoustic and thermal insulating performance. Our initial end-products are noise barriers which has created a starting point for Miljøskærm’s business in Denmark. We are now in a process of developing an innovative thermal insulation product with rodent repellent properties and this will enable us to scale up our production capacity and to expand into the EU.The aim of the SME Phase 1 project is to assess the technical, commercial and financial feasibility of our thermal insulation product with rodent repellent properties. If feasible, we estimate the company will be capable of reaching an accumulated profit of €88M in 2027.