RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An injectable and programmable drug-eluting embolic device' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This project aims to develop a novel platform for drug delivery and treatment for liver cancers. A first in its kind two-step acting platform is described in detail depicting an early step of drug elusion to viable tissue (in contrast to acute embolism) followed by a later stage of vessel blockage to induce tissue necrosis is introduced here. Inspired by the coronary drug eluting stent concept we will introduce a novel porous degradable bead referred as EmboPore used as mini-stents that can elute drugs for predetermined time and collapse at the end of drug treatment period to embolize the tissue. This two-step concept ensures that a proper and massive drug perfusion will be performed prior to occlusion of the blood vessel that is used to induce tumor necrosis. Another important advantage of the gradual blockage is in reduction of the secreted adverse pro-cancer stress signals that occurs in the acute embolism procedure. The product is designed as biodegradable and injectable to fit the current catheters as being used in the standard clinical procedures. Such product is expected to substantially improve the relatively modest clinical outcomes of embolic devices and possibly open new indications such as metastatic liver diseases, gastrointestinal disease and more.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The sustainability of european irrigated agriculture under water directive and agenda 2000 (WADI)' (WADI), addressing dissemination and exploitation.

assistant: **Impact**

The project objective is to analyse the sustainability of irrigated agriculture in Europe in the context of post Agenda 2000 CAP Reform and of the Water Framework Directive. Sustainability must be understood in its three dimensions: economic impact (farm income), social impact (direct labour and rural development) and environmental impact (water consumption, fertiliser.). Both institutions make necessary a broad analysis of the future or European irrigated agriculture. Nowadays these irrigated agriculture system need to be re-evaluated in term of sustainability, instead of the old profitability conception, taken into account, its multi-functional dimension. We will combine qualitative and quantitative analysis, and will implement a diffusion and discussion forum based upon internet technologies from the very starting point of project and using as much as possible FADN data and reviewing publication.Work package A: Set up scenarios framework for WATER POLICY: A1) Analysis of technology and physical structure of irrigation in Europe. A2) Laws and Institutions at national level analysis: water legal status, prices of water, markets of water, supplier companies and institution, structure investment funding, etc. A3) Analysis of European water policy (current situation, Directive proposal for water and normative related with the Environment). The report obtained lead to recommendations to aim to support the design and implementation of European policy. A4) Selection of set of indicators according ODCE guidelines The aim is the selection of a limited number of parameters that can be fed into the models that will be development under the WADI project, in order to evaluate the impact of different policy scenarios on irrigated agriculture and, indirectly, on the environment. A5)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Godel Logics and descriptive properties of the reals' (GOEDELREALS), addressing dissemination and exploitation.

assistant: **Impact**

This project aims at a thorough mathematical connection of descriptive properties of the reals with semantic properties of Godel logics. If we want to discuss logical descriptions of descriptive, i.e. topological and order theoretic, properties, an adequate logic has to be determined by the order structure of the underlying truth value set, and should not depend on quantitative properties. With other words, validity should be invariant with respect to adequate classes of non-trivial isomorphism. The most relevant many-valued logics of this kind are the Godel logics. We will determine to which extent the language of Godel logics is able to represent structural properties of the reals, thus characterizing the expressive power of Godel logics. On the other hand we want to find properties of the reals which provide suitable classifications, i.e. intentional definitions of Godel logics.The expressive power of a logic, i.e. the range of properties representable within the logic, is of great importance as soon as these logics should be put to use. It defines the limits of what can be achieved and what problems can be formulated. For some formalizations of Godel logics (propositional, quantified propositional and w.r.t. propositional entailment) this question has been settled, but for the most important formalization, the first-order Godel logics, results are still scarce, but suggest that an extension of the Cantor-Bendixson Theorem may serve as main method to obtain a characterization of expressiveness. (The original variant of the Cantor-Bendixson Theorem has been successfully applied by the applicant to characterize the recursive enumerability of first-order Godel logics.) An extended Cantor-Bendixson algorithm, which connects the topological analysis with order properties,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cross-talk of cell metabolism and post-transcriptional control via RNA-binding enzymes?' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The role of metabolic enzymes in the post-transcriptional control of gene expression is barely explored, with only a few cases deeply studied so far, such as aconitase 1 in iron metabolism or GAIT complex control of pro-inflammatory genes. Here, we propose to identify metabolic enzymes that interact specifically with mRNA by unbiased proteomic and transcriptomic approaches and to investigate their potential roles as gene expression regulators. Metabolic enzymes able to bind mRNAs will be identified by an effective crosslinking method, followed by oligo d(T) isolation and mass spectrometry in both human and yeast systems. Following this first screening, we will select three conserved key metabolic enzymes involved in the regulation of different metabolic pathways for further in depth exploration. Using cross-linking and immunoprecipitation assays followed by deep sequencing, we will identify the specific pool of mRNAs bound to each selected metabolic enzyme. Next, we will determine the RNA motif and the protein domain responsible for the interaction with biochemical and bioinformatic tools. Finally, the effect of overexpression and depletion of these metabolic enzymes in the post-transcriptional control of their target mRNAs will be analyzed. Overall, the proposed project will explore a potential new layer of cell regulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The photometric evolution and age determinations of unresolved star clusters: the effect of selective mass loss from dissolving clusters', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Star clusters, even unresolved, are ideal chronometers for the study of the star formation history of normal and starburst galaxies in the local Universe. Star cluster ages and masses can be derived from their spectra/photometry by comparing these with cluster evolution models. However, presently available spectrophotometric cluster evolution models do not take into account cluster disruption, mass segregation and the preferential ejection of low-mass stars from the clusters and the resulting changes in the clusters' stellar mass function, effects both seen and of great importance in observations and dynamical cluster models. This leads to (potentially large) errors in cluster age determinations and in the derived star formation histories of galaxies if standard" approaches are taken. We will study the disruption of clusters and changes in their mass function in various environments, using N-body simulations including mass segregation and binary stars.This will be combined with a n improved version of a state-of-the-art cluster evolution program to produce the next generation of spectrophotometric cluster models (spectra, magnitudes, colours, spectral indices) as a function of the physical parameters of the cluster (age, mass, metallicity) and the disruption time scale (intrinsic host galaxy's property)."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Technical and environmental analysis of advanced strategies for the energyvalorisation of biomass'.

assistant: **Concept**

Development of advanced thermochemical processes (namely advanced combustion, gasification and pyrolysis) for the energy valorisation of biomass and assessment of the environmental impacts associated with alternative strategies in the use of this natural resource.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Science and Technology Policies in Developing and Transitions Countries: Reform and Technological Co-operation with Europe'.

assistant: **Innovation**

The project will analyse the scientific and technological development of, and related policy needs in, Greece, Turkey, Hungary and Mexico. The goal is to assess how Europe can contribute to the further development of science and technology in developing and transition countries, and help them to move from past patterns of technology transfer to technology co-development.The study focused on the main forms of technology transfer and co-operation between Europe and the selected countries: direct investment, licensing, trade in equipment and consultancy, and direct co-operation between governments and technology institutions. It will examine the science and technology infrastructure and innovation systems" in each country, and assess how European institutions and enterprises can help increase their contribution to development needs. National innovation systems will determine the ability of the selected countries to respond to the challenges of trade liberalization, economic integration with more advanced economies and continuing rapid technological progress. 1 These abilities will also determine opportunities for European enterprises to invest in and trade with these countries. The output will be a report Month 24(including a series of interim studies after 18 months) which will be structured around the following five themes: - Patterns of trade and technology flows - The science and technology base in the selected countries - The perspective of the industrial sector - Impact of trade liberalisations and integrations on technology performance - Policy implications for the countries and for the EU."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterizing the risk of pesticide use on amphibian and reptile populations based on multiple, ecologically relevant responses' under Seventh Framework.

assistant: **Concept**

Environmental pollution is recognized as one of the major causes involved in amphibian global declines, in spite of which amphibians are not considered in risk assessment of some pollutants like pesticides, being supposedly protected through data retrieved from other vertebrate taxa. This proposal has two focuses; on the one hand, I will identify the impact of pesticides on amphibian populations using novel, ecologically relevant endpoints indicative of population status and viability, such as reproductive behaviours, immune response and pathogen resistance. On the other hand, I will use these ecologically relevant endpoints to check whether protocols of risk assessment of pesticides are effective in protecting amphibians and reptiles from their impact; with this purpose I will compare the pesticide effects on native amphibians and reptiles based on reproductive, immunological and behavioural studies, with effects on surrogate taxa. A field monitoring in areas of pesticide use will serve to characterize the exposure in realistic scenarios. The relevance of the proposal lies in that it i) deals with a recognized major environmental problem (i.e. amphibian and reptile declines) from the perspective of multiple stressors, ii) presents a clear multidisciplinary scope combining zoology, ecology, toxicology, immunology and analytical chemistry, iii) shows many possibilities for transfer of knowledge to governmental agencies through the identification of relevant guidelines for conducting pesticide risk assessment, and to the industrial sector through the development of the best models to be used in such risk assessments; and iv) has potential for further development as validated models will be useful in extended taxonomical, geographical or chemical scales
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative organic/inorganic hybrid materials for multifunctional catalysis' (HYMUCAT).

assistant: **Concept**

Organic-inorganic hybrids are of great interest because they combine the advantage of inorganic solids (high mechanical, thermal and structural stability) and organic molecules (flexibility and functionality). The heterogeneous catalysts are limited in the nature of the active sites and thus the scope of reactions that they can accomplish, whilst the organic molecules can catalyse a larger variety of reactions but suffer from their inability to be recycled. The goal is to use the organic moiety as the active sites and the inorganic solid to provide a way to recover and to recycle the organic sites. The aim of the HYMUCAT project is the synthesis and the characterisation of innovative hybrid porous silicas to produce a multifunctional catalysts having both basic and acid sites. These active sites can act in cascade reactions to provide catalytic activity and selectivity superior to what can be obtained from monofunctional or homogeneous catalysts. Particular attention will be given to the effect of the spatial arrangement of the organic functionalities on the inner surface of porous silica and to the modulation of the strength of the acid and basic sites. Conventional and non-conventional sol-gel processes carried out by a co-condensation will be used to create organic-inorganic hybrids that contain the organic moiety as part of the silica network. Diamines with neighboring atoms and aromatic frames, such as naphthalene, referred as proton sponges, will be used as organic part, they exhibit unusually high basicity constants. Moreover, the weakly acidic silanols, belonging to the silica network, can preactivate the reagents by interaction of the carbonyl groups. This enables the proton sponge in the hybrid to abstract protons with a higher pKa than that of the plain proto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification of Caveolin Sequences involved in Anchorage-dependence of cell growth' under Sixth Framework.

assistant: **Concept**

Integrins are key regulators of gene expression, cell proliferation and migration. Alteration of these processes is central to tumourigenesis. Integrin signals mediate anchorage-dependence of cell growth, while growth of cancer cells is anchorage-independent. Integrins regulate membrane targeting of Rac and Cdc42, also involved in oncogenesis. Integrin-regulated Rac binding sites are in lipid rafts (membrane domains enriched in cholesterol and glycosphingolipids).Internalisation of Rac binding sites is mediated by caveolin-1, a structural component of a subtype of rafts termed caveolae. Caveolin-1 regulates anchorage-dependent growth and is a tumour suppressor. Integrin-mediated retention of phosphorylated caveolin in focal adhesions inhibits raft internalisation, which occurs upon its recruitment to caveolae after cell detachment. These results may provide a molecular explanation for the role of caveolin-1 as tumour suppressor and provide insight into the mechanism of anchorage-independent growth, one of the hallmarks of cancer.The main goal of this research proposal is to study the relevance of this novel mechanism to cancer. This specific project aims to identify sequences within caveolin involved in regulation of raft internalisation, cell cycle progression and anchorage-dependent cell growth. Caveolin sporadic mutations occurring in human cancers will be tested for these effects. This objective integrates into a bigger project that also aims to identify molecular mechanisms by which caveolin regulates anchorage-dependent signalling pathways and cell cycle progression and to identify oncogenes that induce constitutive surface localization of rafts (and hence Rac), and/or changes in phosphocaveolin localization.These studies will contribute to a better understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Speciation of antimony in food webs of selected ecosystems' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Development of reliable and validated complete analytical procedures for the speciation of inorganic, methylated, and ethylated antimony compounds in food webs of aquatic and terrestrial ecosystems by gas chromatography and high performance liquid chromatography on-line coupled to hydride generation atomic absorption spectrometry or inductively coupled plasma mass spectrometry. Transformations of Sb species during different approaches of sampling, sample preparation and storage will be elucidated. A primary emphasis of this work consists in the validation of the various steps of the analytical procedure with respect to the recovery of Sb determining the total concentrations of Sb at all stages of the sample preparation. Moreover, the critical analytical steps of extraction and preconcentration have to be optimized for the different matrices to be investigated. For the characterization of the original state of Sb species patterns in nature the samples studied will be mainly fresh specimens, stored under cryogenic conditions in the Environmental Specimen Bank (ESB) at the Research Center J|lich. From aquatic food webs water, sediment, algae, mussels and fish organs and from terrestrial ecosystems rain water, soils, tree leaves or shoots, possibly grass and deer liver will be studied. After appropriate developments and validation of the analytical procedures, the various matrices from well-defined and well-described sampling sites will be characterized with respect to their pattern of antimony species. Training content (objective, benefit and expected impact) This Marie Curie Research Training Grant, stimulating the mobility and international cooperation of the applicant, will help applicants' intention to get an employment at one of the Joi