RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Building a knowledge Repository for Occupational Well-being Economics Research' (ROWER).

assistant: **Innovation**

The proposed project aims to settle the fundamental basis that will enhance research on Occupational Health and Safety (OHS) Economics, which will allow for the development of policies regarding this issue. This goal will be achieved through a Support Action which will bring together the leading OHS Economists in Europe. Their knowledge will be gathered, interpreted and made available to the community through a dynamic on-line repository which will contain OHS Economics issues and will allow for discussion and communication of principles, case studies and management tools. Two specialised Working Group (WinG) meetings focusing on OHS Macroeconomics and OHS Microeconomics, respectively and two conferences on OHS Economics will attract new contributions in order to assess the impact of changing conditions of economy and labour on OHS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Breaking the code of RNA sequence-structure-function relationships: New strategies and tools for modelling and engineering of RNA and RNA-protein complexes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Ribonucleic acid (RNA) is a large class of macromolecules that plays a key role in the communication of biological information between DNA and proteins. RNAs have been also shown to perform enzymatic catalysis. Recently, numerous new RNAs have been identified and shown to perform essential regulatory roles in cells.As with proteins, the function of RNA depends on its structure, which in turn is encoded in the linear sequence. The secondary structure of RNA is defined by canonical base pairs, while the tertiary (3D) structure is formed mostly by non-canonical base pairs that form three-dimensional motifs. RNA is similar to proteins in that the development of methods for 3D structure prediction is absolutely essential to functionally interpret the information encoded in the primary sequence of genes. For proteins there are many freely available methods for automated protein 3D structure prediction that produce reasonably accurate and useful models. There are also methods for objective assessment of the protein model quality. However, there are no such methods for automated 3D structure modelling of RNA. There are only methods for RNA secondary structure prediction and a few methods for manual 3D modelling, but no automated methods for comparative modelling, fold-recognition of RNA, and evaluation of models. Only recently a few methods for de novo folding of RNA appeared, but they can provide useful models only for very short molecules.Recently, inspired by methodology for protein modelling, we have developed prototype tools for both comparative (template-based) and de novo (template-free) modelling of RNA, which allow for building models for very large RNA molecules. These tools will be further optimized and tested. The major goal is to developed tools for RNA modelling t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum Hydrodynamics: Applications to nanoplasmonics' (QHYDRO).

assistant: **Concept**

Recent years have witnessed a remarkable surge in interest for the electronic properties of new materials, particularly when excited by electromagnetic radiation. This is a very vast domain of research that encompasses all sorts of nano-objects (metallic films and nanoparticles, carbon nanotubes, semiconductor quantum dots,…), new materials like graphene, as well as metamaterials whose structure can be engineered so as to display some particular optical properties.  In this project, we will focus our attention on metallic nano-objects and the composite metamaterials that can be constructed out of them, such as networks of interacting nanoparticles. Standard methods to study the electron response – such as the time-dependent density functional theory or Hartree-Fock equations – are computationally very costly in terms of run time and memory storage. On the other hand, recent approaches rely on much  simpler methods based on improvements of the classical Mie theory.Here, we propose to develop and implement a set of quantum hydrodynamic (QHD) models that are sufficiently simple to be run on standard computers (desktop PC or small university cluster), but contain enough physics to study the electron response beyond the Mie model – in particular nonlinear, nonlocal, and quantum effects. The combination of flexibility and accuracy of QHD models makes them an ideal tool to investigate many open problems in the emerging field of nanoplasmonics.Using this approach, several configurations of nano-objects will be studied, including dimers and trimers of metallic nanoparticles and nanorods, metal-dielectric multilayers, nanoparticles in the vicinity of a thin metal film, and arrays of nanoparticles interacting via the dipole force.


**Keywords:** Nanoparticles,  plasmonics,  quant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Mitochondrial dysfunction is implicated in Parkinson’s Disease (PD), but detailed understanding of the cause and effect in αSyn toxicity is lacking. Through provision of quantitative and systematic characterisation of mitochondrial dysfunction, PD-MitoQUANT will provide unprecedented understanding of the role of mitochondrial dysfunction in PD, identify and validate novel disease biomarkers, and propose innovative therapeutic targets that can be further progressed by the EFPIA partners. The consortium leverages multi-disciplinary expertise in the fields of αSyn biochemistry, iPSC-derived PD models, mitochondrial function and structural analysis, proteotoxicity, ER stress and UPR signaling, systems biology of mitochondrial function, and in vivo animal models. A key focus will be quantitative description and integrated analysis of mitochondrial function and its relation to proteotoxicity; representing a key panel of consortium partners Prehn [RCSI], Abramov [UCL], Corti [ICM] and Koopmann [RUMC] who also have assembled long–standing expertise in primary neuron culture, iPSC-derived neurons, PD in vivo models, proteostasis and ageing studies. These investigations will be supported by expert teams in iPSC-derived in vitro PD models and in vivo PD models from the academic partners (Hunot [ICM], Melki [CNRS], Di Monte [DZNE], Broccoli [CNR], SME [Mimetas] and EFPIA partners [Teva], [Lundbeck] and [UCB]. Through integrated in vitro, in silico and in vivo approaches, and supported computationally by SME [GENEXPLAIN], PD-MitoQUANT will perform thorough and unprecedented investigations of mitochondrial dysfunction.  Finally, the consortium will initiate a European research platform of excellence investigating mitochondrial dysfunction in PD continuing beyond the project, further
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Active PROtection of multi-material assemblies for AIRcrafts' (PROAIR) under Seventh Framework.

assistant: **Objectives**

The proposal is devoted to development of the novel active corrosion protection systems for multi-material combinations used in the aircraft design. The development of such new approaches is only possible via deep mechanistic investigation of the degradation processes in confined environments formed at multi-material joints. The second essential stage is finding the synergistic inhibiting combinations which can provide effective suppression of corrosion processes in the case of galvanically coupled dissimilar materials. The ultimate step is introduction of inhibiting compounds to the protective layers, adhesives and sealants used in multi-material design of aircrafts.The proposal also aims in creation of stimulating and interdisciplinary R&D and training partnership, with actors from the academia and private sector, promoting the exchange of ideas, methods, techniques as well as enabling an accelerated technology transfer from science to industrial scale and of course a continuous collaborations between the stakeholders.The topic demands strongly innovation and interdisciplinary skills, since there is a lot of pressure from the private sector to develop more sustainable solutions for light-weight design of “green aircrafts”. The developed protection solutions must be compliant with environmental regulations, must present reduced thickness/weight, and must promote energy saves, with longer lifetime. Moreover it has to be considered that the related processing and assembly steps have to be economically competitive.  Thus, the actual times are very challenging for this field and new skills and trained people are an acknowledged need.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Navigational system for efficient maritime transport'.

assistant: **Innovation**

There is a strong interest in the maritime community to optimize sailing time (expected time of arrival), reduce fuel consumption and greenhouse gas emissions and minimize maintenance cost. The objective of this project is to develop a sail planning system to help sea masters optimize these criteria. The proposed solution mimics the current human sail planning process. It will use ship specific data collection and real-time local and remote observations (3D-radar, Earth Observation data, etc.) combined with several state-of-the-art nowcast and forecast numerical models. It will monitor actual ship performance and assimilate this information in the sail plan optimization process. The access and systematic exploitation of this ground truth information will provide the unique capability of building &quot;system experience&quot;, constantly improving the performance of different sub-models used in the sail plan optimizer. This will also reduce the sensitivity to ocean and weather forecast errors. The system will automatically and continuously compute and communicate optimized sail plans to a vessel. All relevant information justifying the results will be sent simultaneously (as for example a storm system, dangerous wave zones, security and other relevant information). The execution of the Navtronic system requires a central information centre that will be realized for exchanging ship relevant information and providing optimized real-time sail plans. The central information centre will be part of the GRID distributed processing reciprocity. The Navtronic project is highly end-user driven – the largest market players in the maritime community are partners and support the project with human resources, vessels and infrastructures for tests and evaluations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Celiac Disease autoantibodies targeted against transglutaminase 2: repercussions in vascular biology, disease pathogenesis and treatment' (TRANSVASCED), addressing dissemination and exploitation.

assistant: **Impact**

Celiac disease (CD) is a common heritable autoimmune disorder triggered by gluten-containing cereals which induce a massive immune reaction and destruction of the small bowel mucosa. The disease is hallmarked by the production of antibodies against transglutaminase 2 (TG2), an enzyme involved in angiogenesis. Interestingly CD presents an entire disorganization of the intestinal vasculature where the TG2 autoantibodies are deposited. We recently demonstrated that anti-TG2 antibodies can disrupt and affect the vascular functionality in vitro. Therefore we aimed to study whether antibodies against TG2 can affect vasculature in vivo by increasing TG2 enzymatic activity affecting the extracellular matrix composition and signaling intracellularly. In addition, the inhibition of TG2 enzymatic activity and other molecular pathways can ameliorate the anti-angiogenic effect of CD autoantibodies, offering a potential therapeutical target ordered by the primary users of our study, patients. The results find of the present project will be a step forward in the knowledge of the disease and the pathogenic mechanisms especially those related with the vascular development. To achieve this question, different models of angiogenesis and other molecular methods will be used. Multidisciplinarity is the main strength of the present research combining the knowledge of different fields (molecular biology, clinical observations) as well many collaborations with other researchers and companies. Applicant will contribute with his knowledge about angiogenesis and inflammation while host institution provided the experience in celiac disease research as well the facilities need it making the project feasible. The amount apply is 15,000 € year during 36 month (total 45,000€) to cover consumables, tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Tools for minimally invasive diagnostics' (DIATOOLS) under Seventh Framework.

assistant: **Objectives**

A new generation of molecular tools is becoming available that can digitally record numbers, identities and locations of a broad range of molecular markers for increased diagnostic accuracy. This project will for the first time combine synergistically several groundbreaking technological innovations by the partners, notably padlock and proximity probes with rolling circle amplification for single molecule detection and counting, directed self-assembly of solid phases, and advanced microfluidics and read-out techniques, bringing these from the research lab into integrated instruments useful in routine. This will enable minimally invasive diagnostics, prognostics, and follow-up of treatment of cancers. Blood samples and fine needle aspirates will be subjected to high content, multiplex and multimodal assays of nucleic acids, proteins and interacting complexes thereof in single cells as well as in cell-free bodily fluids. We will use flow cytometry to collect multi-parameter information for large populations of cells, and individual detected molecules will be recorded using a fluorescence activated molecule counter developed by one of the partners. Also, very rare cells and molecules will be targeted through enrichment techniques using novel capturing approaches of unprecedented efficiency. We will apply these diagnostic approaches to characterize biomarkers in solid tumors and in leukemia and lymphoma for minimally invasive diagnostics, monitoring disease progress and selecting optimal therapy, and the assays will be clinically validated in small-scale studies of well-characterized patient samples. This project directly addresses four of the five topics in this call.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SUSTAINABLE MULTI-FUNCTIONAL AND RECYCLABLE HEAT PUMPS' to be submitted under Horizon Europe.

assistant: **Abstract**

Smart-Pumps aims (1) to optimally redesign heat pump components under the newly introduced Design for Additive/Hybrid Manufacturing concept, which apart from operational characteristics, includes all life-cycle parameters, such as recycled material sourcing and component recyclability, for maximum efficiency, sustainability, safety and reliability, (2) to utilize multiple materials which are mixed at different percentages in the various operational sections of heat pump components, following the Functional Grading methodology, thus fully exploiting their properties (mechanical, thermal, electrical, etc) and maximizing material usage efficiency, (3) to embed sensors and devices within heat pump components for monitoring and operational data extraction, and also for actively changing heat pump component structure to optimize operation, (4) to standardize testing and create manufacturing process and assembly protocols, and (5) to create training curricula for all relevant stakeholder on digital design, manufacturing and testing of Smart Heat Pumps.


**Keywords:** heat pump, additive manufacturing, embedded sensors, efficiency, sustainability, performance, training and certification
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bonamia ostrae life cycle investigations, optimised production of resistent Ostrea edulis Spat, and studies of oyster (Ostre Edulis) immune mechanims' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The project addresses the following objectives:- To develop new methods to increase output of relatively resistant oysters- To gain an understanding of the vectors of infection and more accurately assess-risk- To develop method designed to disrupt the life cycle of the parasite, leading to its eradication- To screen for immune parameters in the flat oyster with the objective of identifying the basis of increased resistance observed in the Rossmore group in CRAFT 1 (CT98 9101).These parameters could be targeted in oysters to try to select resistant oysters from natural populations, to boost resistance to this parasite and could also serve to 'tag' the-relatively resistant oyster.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mapping European regional Transport Research and Innovation Capacities (METRIC)', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

METRIC will map regional transport innovation capacity and identify the competitive advantage of identified regions. Based on their strengths, guidelines for the preparation of regional innovation roadmaps (strategy plans) will be developed. METRIC will also explore the regional innovation potential and make recommendations on how to support weak regions. The project will ultimately contribute to the building of a regional culture of continuous innovation that minimizes innovation risks and maximizes its returns.METRIC will base its operating principles in three main blocks of activities: i) Mapping of the transport research and innovation activities, ii) exploring the performance of the regional innovation frameworks and iii) analysing the main principles and typology for regional innovation. The project will deliver a set of recommendations on innovative strategies for regions along with a set of innovation roadmaps based on  best practices. The Smart Specialization Platform (S3P) approach will be used for the roadmaps though a transport sector specific S3P strategy will also be also put forward.  This will be the basis for Structural Fund investments in R&I contributing to the development of the Cohesion Policy.The METRIC partners will combine and utilise multidisciplinary skills, expertise, and on-going work in the field of transport innovation, policy development, regional support and roadmap development. The consortium has been carefully selected based not only on the complementarity of skills but also on access to a very wide network of stakeholders and relevant research material, data sets and studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Central and Eastern European Cluster and Network Area'.

assistant: **Objectives**

Clusters have become an effective instrument to promote and foster innovation, co-operation between SME and R&D-institutes as well as technology transfer. So far, clusters have mainly operated at a regional/local level and only started recently to facilitate cross-border co-operation on a case-by-case project basis.The CEE-ClusterNetwork consortium is composed of geographically neighboured cluster regions in Central and Eastern Europe (see picture) and will use a systematic approach to mobilise and support national/regional innovation policy actors to carry out and design co-operation activities with other competent public authorities. In order to develop and prepare for those future joint trans-regional activities (like common trainee-programmes, mutually open cluster funding programmes etc.), CEE-ClusterNetwork will analyse and map existing structures/initiatives/programmes and define a common standard of the cluster methodology.