RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evolutionary stability, observability, and efficiency' (2014-2020).

assistant: **Innovation**

The existing literature mainly focuses on two kinds of interactions: short-term interactions in which the behavior today does not influence the future, and long-term interactions with the same partner. In the former model, the only stable outcomes are Nash equilibria (which are typically non-efficient), while the latter model allows one to achieve efficient outcomes. Many interesting situations lie somewhere in between, typically when people engage in short-term interactions but future partners may obtain some information about the behavior today. For example, how do people behave when interacting in one-off purchases in an online site with a feedback mechanism (e.g., eBay)?In this project I will fill the large gap in the literature, by characterizing evolutionary stable outcomes when players have limited information about the partner’s past, and how this stable behavior depends on the richness and the structure of the observed information. This will shed new light on indirect reciprocity and its use to achieve efficiency in social dilemmas.The evolutionary stable outcomes capture the long run behavior in a dynamic process of cultural learning. Agents are randomly matched in each round to play a game with a new partner. Each agent may observe some information about the partner’s past behavior. New agents, who join the interactions, usually mimic one of the existing behaviors, with a larger tendency to choose more successful incumbents. Occasionally, few agents experiment with a new behavior.The research agenda includes several theoretical subprojects with various research questions, such as:(1) Would non-material preferences be stable?(2) What will be the influence of non-verifiable reports about past behavior?(3) Which of the (locally) stable outcomes would be selected
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bacteriophage Therapy for Catheter Infection Control' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The primary aim of this project is to develop novel bacteriophage based strategies to combat Proteus mirabilis catheter associated urinary tract infection (CAUTI), a prevalent health-care associated infection for which there are currently no effective countermeasures. Indwelling urethral catheters (IUC) are the most commonly deployed medical devices, it is estimated that ~100 million IUC are used annually in healthcare systems globally, which equates to ~190 catheterisations per minute. However, IUC are vulnerable to infection, undermining their utility, jeopardising patient welfare and posing a substantial economic burden on healthcare systems. Over 40% of CAUTIs may be attributed to P. mirabilis, which poses particular problems in the care of catheterised patients. P. mirabilis causes encrustation and blockage of catheters, leading to serious complications such as pyelonephritis, septicaemia and shock. It is difficult to eliminate from the catheterised urinary tract, even after the catheter is removed, and often causes chronic infection recalcitrant to conventional antibiotic therapy. Given the prolific use of IUC and corresponding prevalence of CAUTIs in healthcare systems across the world, development of bacteriophage based strategies for control of CAUTIs would open a niche in a global market that is projected to reach an annual value of €2 billion by 2015.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Zebrafish as Novel Model for Exercise-enhanced Skeletal and Cardiac Muscle Growth and Immune Functioning' (SWIMFIT) targeting Seventh Framework.

assistant: **Abstract**

Recently, within the borders of a Marie Curie IEF project, we have established zebrafish as a novel exercise model and demonstrated the stimulation of growth by exercise in adult zebrafish (Palstra et al., PLoS ONE, 2010). Exercise may also induce hypertrophy and cardiomyocyte proliferation in zebrafish making it an important model to study vertebrate heart regeneration and improved robustness of fish in aquaculture. Moreover, zebrafish has been recently recognized as a valuable model for immunological studies since they possess an adaptive and innate immune system similar to mammals. Given the beneficial effects of exercise on mammalian immune function, zebrafish can be used to investigate exercise-induced stimulation of immune function.In this project we propose to use this novel exercise model for human and fish and, by applying state-of-the-art techniques, to demonstrate the mechanisms behind the beneficial exercise effects of enhanced skeletal and cardiac muscle growth and immune functioning, and to exercise glucocorticoid knock out and transgenic zebrafish to assess the role of the cortisol stress response at the base of these beneficial exercise effects.SWIMFIT will enable the development of a novel research line on exercise integrating the applicant’s existing expertise on exercise physiology with applying high throughput genomic, transcriptomic and proteomic methodology thereby creating a new scientific niche.At the Institute for Marine Resources and Ecosystem Studies (IMARES) of the Wageningen University, the applicant has postulated a position as researcher aquaculture and is investigating the opportunities for implementation of exercise in aquaculture. Besides these applied studies, this Marie Curie reintegration grant would offer the opportunity to deepen t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The European Centre of Excellence for Engineering Applications'.

assistant: **Concept**

Engineering applications will be among the first exploiting exascale, not only in academia but also industry. In fact, the industrial engineering field is *the* industrial field with the highest exascale potential, thus EXCELLERAT brings together the necessary European expertise to establish a Centre of Excellence in Engineering with a broad service portfolio, paving the way for the evolution towards EXASCALE. All within the frame of the European HPC Strategy realization just pushed forward with the activities on the EuroHPC Joint Undertaking.To fulfil its mission, EXCELLERAT will base on six carefully chosen reference applications (Nek5000, Alya, AVBP, Fluidity (deprecated, replaced with TPLS), FEniCS, Flucs), which were analysed on their potential to support the aim to achieve EXASCALE performance in HPC for Engineering and thus to become candidates to be executed on the Exascale Demonstrators, Pre-Exascale Systems and Exascale Machines .All the facets of such a centre are addressed by EXCELLERAT, from ""non-pure-technical"" services such as access to knowledge or networking up to technical services as e.g. Co-Design, Scalability enhancement or Code porting to new (Exa)Hardware. As the consortium contains key players in HPC, HPDA or Knowledge Transfer and having for all reference applications the developers on board, impact (e.g. awareness creation but also feedback into the code development itself) is guaranteed. The scientific excellence of the EXCELLERAT consortium enables evolution, optimization, scaling and porting of applications towards disruptive technologies and increases Europe´s competiveness in engineering.Within the frame of the project, EXCELLERAT will prove the applicability of the results to other HPC engineering applications then the six chosen. Thus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'varnish and sol-gel multifunctional ProtectIve cLear cOat for aeronauTics' (PILOT) under Horizon 2020.

assistant: **Objectives**

The project PILOT aims to develop two types of formulation technologies classes; a new UV hybrid varnish, which will combine the use of organic and silicone epoxy materials cured by the UV technology and a new hybrid solgel coating, where organic/silicone networks are reinforced by using colloidal particles of silica. Both technologies can be applied on a final paint scheme, but each of them has their particularities in terms of formulation, application and final properties. These differences will allow to cover a very large range of possibilities and will increase the chance of success of this project.The approach of the project is to get an efficient optically transparent multifunctional clear coat, which will able to protect the surface of the wings of business jet or HTP. While keeping the laminar flow, the technical solutions will have the capacity to:• Protect the substrate against contamination• Protect the substrate against icing formation• Resist to the erosion• Resist to the UV degradation• Dissipate the electrostatic charges• Be easily repairedTo reach the target of the project, the consortium considers two different technologies, which have already shown their ability to match with Aerospatiale needs. For each approach, an existing solution has been selected. Several properties, according to the technical requirements, have been already tested. The project PILOT will fine tune them in order to fulfil the technical specifications. The project will start with a bibliographic study, whose objectives are to make a state of the art of the last updated technologies,  a legislation survey, a screening of the commercial raw material in order to design the update formulations coatings. Then, based on the literature, the coatings will be formulated and applied on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Spatio-temporal regulation of antigen presentation and cell migration' (STRAPACEMI).

assistant: **Concept**

The immune system is constituted by different cell populations, which circulate between lymphoid organs and peripheral tissues as a result of their high migratory capacity. We have shown that Antigen (Ag) processing and migration of Ag Presenting Cells (APCs) are co-regulated by a protein complex that contains the MHC class II-associated Invariant Chain (Ii) and the actin-based motor protein Myosin II. While the association between Ii and Myosin II promotes Ag processing for presentation onto MHC class II molecules, it impairs APC motility, suggesting that the use of common regulators enables APCs to coordinate Ag processing and cell migration in time and space. We here propose an innovative multi-disciplinary approach, at the interface of immunology, cell biology and biophysics, aimed to unravel the fundamental mechanisms allowing the coordination of Ag processing and APC migration and to evaluate their impact on the adaptive immune response. Our specific aims stand as follows: (1) Combine two-photon microscopy in living tissues and micro-fabricated tools to highlight the molecular mechanisms by which the Ii-Myosin II complex couples Ag processing and cell migration in APCs. (2) Use mouse models to provide a quantitative analysis of the impact of the coordination of Ag processing and APC migration on the onset of the adaptive immune response in vivo. (3) Extend this analysis by performing a genetic screen to identify the molecules and cellular parameters that are critical for coordination of Ag processing and APC migration. The molecular mechanisms that regulate cell motility being conserved between the different types of leukocytes, we foresee that our results will shed light on the fundamental immunological question of how immune cells in general regulate their indiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Targeting the adaptive capacity of prostate cancer through the manipulation of transcriptional and metabolic traits'.

assistant: **Objectives**

The composition and molecular features of tumours vary during the course of the disease, and the selection pressure imposed by the environment is a central component in this process. Evolutionary principles have been exploited to explain the genomic aberrations in cancer. However, the phenotypic changes underlying disease progression remain poorly understood. In the past years, I have contributed to identify and characterise the therapeutic implications underlying metabolic alterations that are intrinsic to primary tumours or metastasis. In CancerADAPT I postulate that cancer cells rely on adaptive transcriptional & metabolic mechanisms [converging on a Metabolic Phenotype] in order to rapidly succeed in their establishment in new microenvironments along disease progression. I aim to predict the molecular cues that govern the adaptive properties in prostate cancer (PCa), one of the most commonly diagnosed cancers in men and an important source of cancer-related deaths. I will exploit single cell RNASeq, spatial transcriptomics and multiregional OMICs in order to identify the transcriptional and metabolic diversity within tumours and along disease progression. I will complement experimental strategies with computational analyses that identify and classify the predicted adaptation strategies of PCa cells in response to variations in the tumour microenvironment. Metabolic phenotypes postulated to sustain PCa adaptability will be functionally and mechanistically deconstructed. We will identify therapeutic strategies emanating from these results through in silico methodologies and small molecule high-throughput screening, and evaluate their potential to hamper the adaptability of tumour cells in vitro and in vivo, in two specific aspects: metastasis and therapy response. Can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Mobile IP based Network Developments'.

assistant: **Concept**

It is expected that systems beyond 3G will provide seamless access to broadband services over a wide range of air interfaces and will allow new business models for providing and running these services and the underlying networks. Considering these user requirements on future mobile networks, the project MIND will extend the concepts of a broadband multimedia IP-based radio access technology. The research conducted by MIND includes new network topologies like ad-hoc, self-organising networks, improved QoS support in IP mobile networks, enhancements of HIPERLAN/2 and investigations of spectrum requirements for systems beyond 3G. In this context, HIPERLAN/2 is seen as part of a 4G system, which complements traditional cellular systems such as UMTS. The resulting concepts of the MIND access network will be validated by running trials based on UMTS, HIPERLAN/2, and IPv6 testbeds. Results will be contributed to relevant standards bodies.Objectives:1. Overall aim: To facilitate the rapid creation of broadband multimedia services and applications that are fully supported and customised when accessed by future mobile users from a wide range of wireless access technologies.2. Research areas: To extend the concepts of IP mobile networks. This includes: new network topologies - ad-hoc, self-organising and meshed networks; enhanced support for QoS, ad-hoc networks and self organisation at all layers of HIPERLAN/2; QoS support in IP-based mobile networks; investigation of the spectrum requirements for systems beyond 3G.3. Trials: The project will research the use of WLAN and an IP-based access network as a complement to UMTS for high bandwidth provision in hot spot areas.4. Delivery: To contribute actively to standards bodies and industry forums.Work description:To achieve the object
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Wireless deep BRAIN STimulation thrOugh engineeRed Multifunctinal nanomaterials'.

assistant: **Concept**

BRAINSTORM will introduce an innovative, scalable, wireless, multimodal nanoinvasive neuromodulation technology suitable for independent and switchable excitation and inhibition of deep brain neurons. BRAINSTORM breakthrough relies on novel smart anisotropic magnetic nanomaterials (SMNs) acting both as nanoscale ‘heaters’ and as ‘torquers’ by leveraging either hysteretic losses under kHz frequencies or transitions from vortex to in-plane magnetization under Hz frequencies. Intrinsic bimodal functionality that permits direct control of thermosensitive or mechanosenitive neurons, will be boosted by advanced polymer functionalization to transfer torques to electrical signals trough piezoelectric coating, and to enable  transport and delivery of viral vectors to targeted neurons for genetic targeting with sensory channels. SMNs will also be steered to endogenous sensory channels relying on antibody targeting. Selected actuation of ion channels that respond to thermal or mechanical stimulus will permit selective activation or inhibition of targeted neuronal populations identifiable by magnetic resonance imaging. Advanced driving electronics will include to metamaterial solenoid coils for rapid frequency switch for control of ‘mechanical’ or ‘thermal’ functionality while  focused ultrasound will facilitate non invasive delivery of SMNs in the targeted brain area. The ability of the BRAINSTORM platform to shape behaviour and demonstrate therapeutic potential by modulating the excitation/inhibition balance through thermal/mechanical/electrical modalities will be demonstrated in mouse models of Fragile X syndrome.


**Keywords:** Advanced Functional Nanomaterials, Biomaterials Engineering, Smart and Responsive Polymer Coatings,  Targeted Neuromodulation, Wireless Stimulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Toward a Complete View of Star Formation: The Origin of Molecular Clouds, Prestellar Cores, and Star Clusters' to be submitted under Seventh Framework.

assistant: **Abstract**

Understanding star formation from large to small scales is a major unsolved problem of modern astrophysics, fundamental in its own right and having a profound bearing on both galaxies and planet formation.To achieve a breakthrough in our observational and theoretical knowledge of star formation, we propose to confront numerical simulations with observations obtained with state-of-the-art instrumentation, including instruments developed by our group. We will investigate three key areas: a) Origin of filamentary molecular clouds; b) Core formation within filaments; c) Fragmentation of prestellar cores into binary stars and protoplanetary disks. Our approach is novel in that we combine observational, theoretical, and instrumental efforts within the same team, and we address star formation coherently from large to small scales, allowing us to establish links between the « macrophysics » (eg. global star formation in galaxies) and the « microphysics » of the problem (eg. formation of individual solar systems). This project will be based on extensive (sub-)millimeter continuum and spectral line studies with the Herschel Space Observatory, IRAM 30m telescope/interferometer, APEX 12m telescope, and ALMA interferometer. ORISTARS will benefit from our large « Gould Belt Survey » key project with Herschel providing the first complete census of prestellar cores and young protostars in nearby star-forming complexes. We will extensively use our lab’s magnetohydrodynamic code RAMSES. We will also take advantage of technological innovations made at CEA for the Herschel-PACS and ArTéMiS instruments to develop a large 1.2mm bolometer array/polarimeter (« Polar-Channel ») for the next-generation millimeter continuum camera at IRAM. Polar-Channel will be a new powerful tool to map polarize