RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A sonogenetic brain-machine interface for neurosciences and visual restoration', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Brain-machine interfaces are classically based on multi-electrode arrays. Optogenetics has revolutionized this ability to control neuronal activity through ectopic opsin expression but its application to large brains remains limited because of tissue light absorption and scattering. Ultrasound waves have been proposed for remote neuromodulation, but this approach has remained restricted to low-frequency excitation, to prevent brain tissue overheating, at the expense of spatial resolution. The expression of mechanosensitive proteins in neurons has recently made it possible to achieve the ultrasound (US) activation of neurons at high US frequencies, an approach named “sonogenetic”. Using the MscL mechanosensitive ionic channel, we recently provided a first proof of concept in rodents that cortical neurons can be activated in vivo by ultrasounds at a high spatiotemporal resolution and low intensity. Here, we propose to develop an integrated sonogenetic strategy for distant activation/inhibition of neuronal networks by ultrasound waves in large primate brains.  The project includes: 1) optimizing and diversifying the sonogenetics actuators for safe neuronal control 2) designing technologies for patterned ultrasound stimulations, 3) demonstrating efficacy and high spatiotemporal resolution of the sonogenetic approach in controlling the primate visual cortex.  This project is based on a unique synergistic combination of expertise, with a synthetic biologist in ion channel engineering, a neurobiologist with expertise in vision, and a physicist with expertise in ultrasound technologies. These 3 PIs will be supported by an expert in AAV vector mediated delivery. The project outcomes will be a novel brain-machine interface for investigating neural circuit function even deep withi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Multivalent interactions driving RNP dynamics in development and disease'.

assistant: **Objectives**

Ribonucleoprotein complexes (RNPs) play many key regulatory roles in development. Moreover, mutations causing cancer or neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), often occur in RNA-binding proteins (RBPs). These mutations are concentrated in the intrinsically disordered regions (IDRs), which play a central role in the control of RNP assembly and disassembly. RNP dynamics is often driven by multivalent interactions that are mediated by multiple elements within IDRs of RBPs, which can condense the RNP such that it separates from the surrounding liquid through the phenomenon of liquid-liquid phase separation. Transcriptomic insights into the physiological functions of such multivalent RNP assembly are needed to understand their regulation, or deregulation through disease-causing mutations. Here, we will build a framework of experimental and computational methods to study the mechanisms by which the dynamic multivalent interactions drive RNP remodelling, and how such RNP dynamics contributes to cellular transitions in development and disease. The first objective will be to identify the functions of specific RBPs in cell-state transitions during neuronal differentiation, and the mechanisms of IDR-mediated multivalent interactions in these functions. The next objective will be to establish new tools to manipulate RNP assembly through multivalent RNA binding sites and IDRs. Finally, the new insights and tools will be integrated with the goal to fine-tune the RNP assembly of ALS-mutant RBPs, and thereby ameliorate their toxicity.


**Keywords:** GBP: GFP-binding protein (nanobody), IDR: intrinsically disordered region, LINE: long interspersed nuclear element, LLPS: liquid-liquid phase separation, RBP: RNA binding protein, RNP: ribonucleoprotein co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Updating the mind: The mechanisms behind behavioural change' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Translation of basic research on human executive control into facilitating behavioural change is a holy grail for psychologists and neuroscientists. Adaptive behaviour is attributed to executive functions that update the cognitive system. But how system updating mechanisms regulate behavioural change is still unclear. This stems from a lack of careful process analysis and a failure to integrate findings from different research areas.My proposal consists of three innovative subprojects. In the first subproject, I aim to develop a unified account of system updating and behavioural change. I propose that three well-defined cognitive processes (detection-selection-implementation) underlie all forms of updating; each component may be influenced by preparation or practice. In the second subproject, I aim to show how stress and incentives, which influence behavioural change outside the lab, modulate the updating processes studied in Subproject 1. This will lead to much richer models of updating and control. Finally, the third subproject will focus on the role of rules in system updating. More specifically, I will examine how both children and adults acquire new rules and how a rule-based control network can develop and strengthen. This may also provide a framework for the development of treatments. In each subproject, I will use carefully designed behavioural paradigms and integrate techniques such as neurostimulation, EEG, and mathematical modelling of decision-making to specify how updating occurs and how variation in the effectiveness of updating arises.The proposed work will substantially extend my previous work on response inhibition and executive control. I will synthesise work in cognitive, clinical, and social psychology, cognitive neuroscience, and neurobiology; and b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigation of extreme flood processes and uncertainty', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Dams and flood defence structures are essential to modern life in Europe. The IMPACT project involves 9 participants from 8 countries in a programme of research to investigate extreme flood and failure processes (breaching, sediment movement, urban/rural flood propagation) and the risk and uncertainty associated with each process. These processes contribute the greatest uncertainty to flood prediction. Research will investigate processes through a combination of laboratory and fieldwork and case studies. A unique opportunity to undertake controlled failure of 6m high embankment dams will be used to provide basic data for the breach and sediment investigation. Each research area will lead to improved understanding and predictive models of the flood processes, with an appreciation of the impact that each process may have on flood risk and any associated uncertainty - and in turn implications for end user applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Analysis of the T cell’s Tactical Arsenal for Cancer Killing' (ATTACK) under Horizon 2020.

assistant: **Objectives**

The ATTACK consortium will develop a new biotechnology based on harnessing a previously unknown natural cytotoxic mechanism of T cells to fight cancer. Cytotoxic T cells (CTL) protect us against intracellular pathogens and cancer by killing infected and cancerous cells. It has been believed that CTL operate on two different time scales of killing by releasing soluble cytotoxic proteins from dense core granules into the immunological synapse between the T cell and target cells (seconds/minutes) and by FasL-mediated apoptosis (hours/days). Members of the ATTACK consortium have independent observations that converge on a previously unknown weapon in the T cell tactical arsenal: stable supramolecular attack particles (SMAPs) that kill target cells (hours). This raises the possibility to engineer these particles to operate independent of T cells. Baldari has discovered that intraflagellar transport proteins sort cytotoxic proteins within the CTL. Rettig has revealed a new storage depot in CTL called a multicore granule that is distinct from the dense core granule. Dustin uncovered that CTL release SMAPs into the immunological synapse to kill targets. Valitutti has called attention to active resistance of tumour cells to synaptic attack, highlighting the strategic advantage of a non-synaptic attack. The consortium has expertise in mouse models, gene editing in primary T cells, super-resolution and live cell microscopy, and microfluidics. The goal of the ATTACK consortium will be to work closely together through 4 work-packages to determine 1) how SMAPs are made, 2) how they are released, 3) how they work and 4) how cancer cells respond. The consortium will integrate all it learns to develop the biotechnology of SMAP enhancement in engineered T cells, recombinant SMAPs, and sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'HIgh speed Key technologies for future Air transport - Research & Innovation cooperation scheme' to be submitted under Seventh Framework.

assistant: **Abstract**

HIKARI (“light” in Japanese) aims at pursuing and bringing one step further cooperation between Europe and Japan in the field of high speed transport (HST).Such a disruptive approach to commercial air transport will foster innovation, ensure leadership in high technology areas, and contribute to ACARE goals by studying alternative fuels and low emissions propulsive technologies. But for such a program to result in concrete solutions for the future traveler, it is mandatory to create international synergies between the most active consortia on the subject.HIKARI will therefore the bases to a fruitful European-Japan partnership in HST, gathering the most renowned partners. It includes industies (EADS subsidiaries MBDA and Astrium, EADS Innovation Works department, and IHI Aerospace),research centers (ESTEC, DLR, CIRA, ONERA, NLR, CNRS and JAXA), and Universities (The University of Tokyo and EASN). Some members have worked with the IPCC, proving that environment is at the heart of such a development. Finally, HIKARI integrates partners with competencies in market analyses: Airbus “Market Forecast” department, Oxford Economics, SME specialized in economic analyses and transport issues, and JADC.The primary output from HIKARI will be roadmaps based on synergies between different projects, e.g. ATLLAS, LAPCAT, ZEHST, LEA, proposing common experimentation plans to contribute to definitive validation of key technical areas by 2020 or earlier. To support this, studies will be run on demand and cost assessment and on the economic impact of HST, and in three technological areas currently of interest to both European and Japanese partners: fuel and environment, thermal and energy management, propulsion. Output from these activities will be integrated in the roadmaps.Next steps beyo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Lithium-Conductive Phase-Independent Electrolytes' (Li-PIEs), addressing dissemination and exploitation.

assistant: **Impact**

I propose combining organic synthesis, theoretical modelling, and materials science to develop a fundamentally new type of lithium- conducting electrolyte. Electrolytes are a vital part of modern life – for example, they are key components of the lithium-ion batteries powering personal electronics and electric vehicles. The electrolyte acts as the medium to transfer charges between the electrodes and its properties and performance depends on the type of material used. Different requirements associated with different sizes and types of devices is driving the development of new electrolyte materials.Traditionally, these materials are classified as either solid- or fluid-phase electrolytes, and the mechanisms of charge transfer differ between the two phases. Recently, a new type of electrolyte has been developed by the host PI that can function as either a solid or liquid electrolyte without losses in performance – they are phase-independent electrolytes (McGonigal et al., Science, 2024, accepted). However, these materials transport anions, while most batteries require cation-conducting electrolytes (e.g., lithium ions). To harness the potential of this new class of  electrolytes, this concept must be adapted to apply to cation-conducting electrolytes, and this requires the development of newmolecular designs, their synthesis and characterisation.I will use DFT to model the structure and assembly of cyclopentadienide anions to identify candidates that have suitably diffuse charge and flexible structures to act as phase-independent electrolytes. I will then synthesise the top candidates and characterise their phase transition temperatures, phase structures, and lithium-ion conductivities. The relationship between molecular structure and the material properties will be devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Human Resource Management Tool Based on Emotional Intelligence' (Appytalent).

assistant: **Innovation**

There is significant evidence that emotional intelligence is the single most important factor when considering job performance. This makes sense. We are all aware of the importance of being able to understand and manage our emotions, yet this insight is barely considered in human resource management.Playforapply have developed a Software as a Service platform, Appytalent, which allows employers and employees to assess an individual’s emotional intelligence. They can then identify what emotional areas the individual needs to develop in order to effectively perform their chosen job and provides learning content for the individual to improve their emotional intelligence in these areas. Finally, a recruitment module allows human resource departments to identify job seekers that match the emotional intelligence profile they are recruiting.This SaaS is currently in a beta phase of development and is being trialled by several companies, including the Open University of Catalauna. Playforapply want to bring this new way of managing human resources to the market through the SME instrument. The aim will be to first carry out a feasibility study that will consider the technological requirements and economic potential of the market, before an SME phase 2 will complete the development and undertake a product demonstration in Europe, Australia and the USA. By 2020, Playforapply estimate that they will be generating profits of almost 3M€, with a return on the SME instrument project investment of 342% within 3 years of project completion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'How Land Carbon Dynamics Shape the Rise and Fall of Atmospheric CO2' (PostPeak).

assistant: **Concept**

PostPeak tackles the pressing questions surrounding Earth's transition into a post-peak CO2 era. The carbon cycle determines how much of the anthropogenic carbon stays in the atmosphere, and warms the planet. It will also shape the trajectory of atmospheric CO2 once emissions level off, with lingering legacy and hysteresis effects.I hypothesize the land carbon cycle is the key modulator in this transition, and accurately predicting its dynamics is essential for understanding how the entire climate system will respond to declining CO2 emissions.  Despite decades of research, the myriad factors underlying land carbon dynamics remain poorly understood, and uncertainty prevails.To address this knowledge gap, the project PostPeak introduces a fundamentally new approach to global land carbon modeling, embedded in Earth system models. The approach capitalizes on the rapidly growing body of Earth observations and machine-learning algorithms, guided by process understanding. Using this hybrid model, we can explore the full range of plausible land dynamics, constrained by multi-stream observations, and provide a robust framework for addressing key questions about the post-peak era. Specifically, PostPeak's research aims to: (i) elucidate the spectrum of land dynamics adhering to global observational constraints; (ii) quantify the resulting spill-over effects into the post-peak emission era; (iii) determine how these dynamics modulate the timing and nature of falling CO2 levels; and (iv) identify where and how hysteresis effects impact ecosystems when CO2 is falling.The liaison of AI-powered land carbon dynamics and versatile Earth system modeling in PostPeak, promises a leap forward in climate-carbon system science and provides an unique opportunity to clarify the land carbon cyc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Aerobiology to Poznan'.

assistant: **Objectives**

AEROTOP will lead to the introduction of aerobiology at Adam Mickiewicz University in Poznan. We plan to increase our knowledge about new methods for measuring concentrations of pollen and fungal spores indoor and outdoor; the influence of meteorological factors on variations in concentrations of pollen and fungal spores; methods underlying the construction of forecasting models of concentrations of pollen and fungal spores of allergenic taxa; and creation and management of data bases for monitoring results for local, regional and national needs. AEROTOP will create opportunities for cooperation between allergologists, botanists, microbiologists, phenologists, meteorologists, agricultural sciences, forestry, and researchers in tourism and other disciplines, from the University and neighboring institutions of higher education in Poznan. Working models established in AEROTOP will be transferred to other institutions of higher education in Poland. The organization of workshops for aerobiologists from other parts of Poland is planned during visits of specialists from collaborating European institutions. The international research cooperation undertaken as part of the project is expected to lead to joint presentations and publications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on '100% recovery and RECYCLing of construction vehicle crAwler TRACKs into constituent rubber and steel for sustainable raw material supply'.

assistant: **Concept**

Aquablast Limited, www.aquablast.co.uk, are pioneers of Ultra High Pressure (UHP) waterjet technology with operatingpressures up to 60,000 psi, which is now an industry standard for steel and concrete surface preparation and cutting.We are now introducing UHP water techniques to the recycling industry through Recyclatrack- a process that recovers andrecycles end-of-life rubber crawler tracks using UHP water-jets.Recyclatrack has been developed so that construction equipment Original Equipment Manufacturer (OEMs), Maintenance,Repair & Overhaul (MROs) and plant hire companies can dispose of growing numbers of decommissioned steel/rubbercomposite crawler tracks safely and cost-effectively with a sustainable and environmentally compliant process.Recyclatrack is a patent-pending ‘green’ solution for this problematic waste stream , achieving 100% recycling of scrapcrawler tracks to recover high grade ferrous scrap and rubber crumb, both of which are readily integrated back into themarket.