RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Computational Proteomics Training European Innovative Network' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

PROTrEIN is a Training Network composed of 12 beneficiaries, and 8 partner organizations, from the academic and non-academic sectors with the mission to train a new generation of specialized bioinformaticians and  improve their future employability while tackling the main challenges in computational proteomics. Mass spectrometry (MS) is one of the most powerful technologies for the study of the cellular proteome, and it is present in many translational research projects for the diagnosis and prognosis of multiple diseases, and for elucidating the mechanisms of action of drugs of medical interest. While several proteomics workflows are well established, the field is fast evolving with new acquisition methods and high-content data structures that expand the applications of the technology and make it one of the principal platforms in the multi-omics universe. Many of these developments require the assistance of artificial intelligence for the acquisition of next generation proteomics datasets, as well as the development of new processing algorithms to reveal hidden proteoforms, interactions, and protein modifications. Moreover, the usage of the new experimental possibilities requires the development of interactive and highly-visual tools for the integration and presentation of proteomics data with other omics datasets. Although addressing these different needs is crucial to deliver major contributions in our understanding of biological processes, the shortage of sufficiently trained bioinformaticians represents a major limitation. Therefore, PROTrEIN puts together an ambitious scientific and training programme to tackle both the challenges in proteomics research and the training of highly valuated professionals by mastering them on: a) the MS raw data structure and informa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Isolation of regulatory elements controlling the formation of isoprenoids' to be submitted under Fifth Framework.

assistant: **Abstract**

Objective To isolate from tomato regulatory gene sequences that control isoprene formation in fruit that control isoprene formation in fruit. This will be achieved by:1. Preparation of an activation tang T -DNA vector containing Cam 35 S enhancers and phone syntheses promoter2. Transformation of the Micro tom variety of tomato with the T DNA vectors and tissue culture3. Regeneration of transgenic plants and phenotypic analysis by metabolite profiling of isoprenoids4. Detailed analysis of fruit for altered carotenoid/isoprenoid changes5. Characterisation of T DNA insertions of plants with altered isoprene levels6. Generation of stable progeny and confirmation of phenotype by retransformation of tagged sequences
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Are marine living microorganisms influencing clouds?' (Sea2Cloud).

assistant: **Innovation**

Earth, as a whole, can be considered as a living organism emitting gases and particles in its atmosphere, in order to regulate its own temperature (Lovelock, 1988). In particular oceans, which cover 70% of the Earth, may respond to climate change by emitting different species under different environmental conditions. At the global scale, a large fraction of the aerosol number concentration is formed by nucleation of low-volatility  gas-phase compounds, a process that is expected to ultimately determine the concentrations of Cloud Condensation Nuclei (CCN). Nucleation occurrence over open oceans is still debated, due to scarce observational data sets and instrumental limitations, although our recent findings suggest biologically driven nucleation from seawater emissions. Marine aerosol can also be emitted to the atmosphere as primary particles via bubble bursting, among which living microorganisms are suspected to act as excellent ice nuclei (IN) and impact clouds precipitation capacities. The main goal of this proposal is to investigate how marine emissions from living microorganisms can influence CCN, IN and ultimately cloud properties. We will investigate the whole process chain of gas-phase emissions, nucleation and growth through the atmospheric column, and impact on the CCN population. We will also quantify marine primary bioaerosol emissions and evaluate how they impact IN and cloud precipitation capabilities. Experiments will be performed in the Southern Hemisphere, especially sensitive to the natural aerosol concentration variability. We will use an original approach of field mesocosms enclosing the air-sea interface, to link marine emissions to the biogeochemical properties of natural seawater, combined with ambient aerosol measurements simultaneously at low an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evaluating the conservation effectiveness of alternative land management scenarios using a state-of-the-art eco-evolutionary modelling platform' (ConservaTEAM).

assistant: **Innovation**

Human population growth is placing ever increasing demands on using land for housing and for food and fuel production1. This demand is driving rapid land use change across much of the globe, in particular in developing countries, which poses a major threat to biodiversity and the ecosystem services it provisions. Simultaneously, climate is changing rapidly, and thus biodiversity faces the joint threat of land use and climate change; not only will species need to be able to persist in heavily degraded landscapes, but they are likely to have to shift their ranges through highly fragmented habitat patches embedded within a hostile matrix. A key role for applied ecology over the coming years will be to provide clear recommendations on how conservation activities can optimise the landscape structure such that as much biodiversity as possible is likely to be retained. There is a need for new tools that can help stakeholders, including land planners and managers, make informed decisions. In this project, I will use a novel, individual-based modelling platform, RangeShifter to test, in silico, the likely effectiveness of alternative future land management scenarios in terms of their ability to protect forest bird biodiversity. As a case study, the project will focus on the Eastern Arc Mountain Range (EAM) in Kenya and Tanzania, a region of exceptional biodiversity and endemism, but which has lost most (80 %) of its native forest cover. An important aspect of the project is that it seeks co-production of knowledge with stakeholders, who will be actively involved throughout in terms of developing and evaluating the effectiveness of alternative scenarios.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Differences in European Legal Cultures: A Study on Dispute Agreements As a Form of Private Regulation' in the context of a Seventh Framework call.

assistant: **Objectives**

The proposal focuses on dispute agreement as to evidence, qualification and interpretation. Those are increasingly relied upon by the parties, in consumer and business contracts in domestic and cross-boarder transactions. They provide for a private regulation and are meant to impose the solutions parties agreed upon in case of disputes as to the contract. The legal effect attach to these agreements differs among the major European jurisdictions. I will demonstrate that these differences reflect deeper, underlying differences in legal culture in the major European jurisdictions. The research will include 3 steps. First, a comparative and analytical enquiry as to the legal effects of dispute agreements (UK, France and Germany and EU Principles). The purpose of this phase is to show for each jurisdiction to what extent the parties are allowed to depart from the usual rules on dispute and, therefore, the depth and limits of the freedom granted to the parties to modify the power of the judge. Second, a synthetic analysis of the extent to which the limits to the enforceability of private regulation can provide evidence as to accepted deviation from the normal public judicial role. The interest of this analysis is to show the relationship between restrictions on freedom of contract and core cultural fundamental procedural principles (judicial impartiality, principle of fair trial, etc.). Third, an assessment of prospective changes on these issues in connection with the procedural principals directly or indirectly stated in international norms such as the European Convention of Human Rights. This step reaches out directly to European Private Law as such and contributes to its construction.. A guide on the comparative effect of dispute agreements is, per se, a useful tool for tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Assessment of volatile analysis for embryo selection during in vitro fertilisation'.

assistant: **Innovation**

In vitro fertilisation (IVF) has irrupted as the most important alternative for getting pregnant in a global world with decreasing natality rates. Currently, IVF success rate is around 20%. In order to improve it, the selection of the most suitable embryo for implantation is the most important factor. In the proposed project, we aim to assess embryo selection based on the analysis of the volatile organic compounds (VOCs) they emit during their development. Gas chromatography coupled to mass spectrometry (GC-MS) technique will be employed in the first step of the project for identifying the pattern of VOCs that characterise the embryos that successfully reach the blastocyst stage, as well as the blastocysts that hatch. An electronic nose system, which possesses several advantages over the GC-MS technique, such as portability, ease of use and considerably lower price, will be next developed for the selective detection of the VOC patterns identified by the GC-MS studies. Initially, the study will be performed on bovine during fellow’s placement at the Beneficiary. The electronic nose that will be developed for the bovine model will be tested on humans in a real-world environment during the additional non-academic placement of the researcher at the business partner. The results of this test will constitute the basis for the future development of a reliable device for the selection of the most suitable embryos for successful IVF outcomes.


**Keywords:** Volatile organic compounds,  Gas chromatography, Mass spectrometry (GC-MS),  Electronic nose,  Embryo selection,  In vitro fertilisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimised Solar Assisted Heating and Ventilation Design in Copenhagen, Piemonte and Poland as Part of European Green Sol' under Fifth Framework.

assistant: **Concept**

The Green Solar Regions " project is linked with other proposals as part of the so-called "European Green Solar Cities" cooperation, which is made in relation to the ongoing cooperation in the European Green Cities Network, EGC. A total of five cooperative projects have been sent to the EU-energie programme with a proposal to be "clustered" as part of the EGC cooperation. The aim of this proposal is to demonstrate energy savings using solar technologies of various kind. Three countries are involved, Denmark, Poland and Italy the overall aim is to reduce the environmental impact by over 55% and over 45% in the energy consumption. There will be knowledge transfer within the European Green City cooperation it is aimed to show how you can optimise use of innovative solar energy technologies together with energy savings and an optimised energy supply for different types of buildings."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Using Bariatric Surgery to Discover Weight-Loss Independent Mechanisms Leading to the Reversal of Fatty Liver Disease' (BARINAFLD) targeting Horizon 2020.

assistant: **Abstract**

Non-Alcoholic Fatty Liver Disease (NAFLD), a disease characterized by accumulation of lipid droplets in the liver, is the major precursor for liver failure and liver cancer, and constitutes a global health challenge. An estimated 25% of the adult population suffers from NAFLD, but no FDA approved drugs are available to treat this condition. Obesity is a major NAFLD risk factor and weight-loss improves disease severity in obese patients. Bariatric surgeries are an effective treatment for obesity when lifestyle modifications fail and often lead to improvement in NAFLD and type 2 diabetes.The overreaching objective of this proposal is to combine bariatric surgery in mice and humans with advanced molecular and computational analyses to discover novel, weight-loss independent mechanisms that lead to NAFLD alleviation, and harness them to treat NAFLD. In preliminary studies, I discovered that bariatric surgery clears lipid droplets from the livers of obese db/db mice without inducing weight-loss. Using metabolic and computational analysis, I found that bariatric surgery shifts hepatic gene expression and blood metabolome of post-bariatric patients to a new trajectory, distinct from lean or sick patients. Data analysis revealed the transcription factor Egr1 and one-carbon and choline metabolism to be key drivers of weight-loss independent effects of bariatric surgery. I will use two NAFLD mouse models that do not lose weight after bariatric surgery to characterize livers of mice post-surgery. Human patients do lose weight following surgery, therefore I will use computational methods to elucidate weight-independent pathways induced by surgery, by comparing livers of lean patients to those of NAFLD patients before and shortly after bariatric surgery. Candidate pathways will be s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Computational Design of Novel Functional Proteins for Immunoengineering' (DeNovoImmunoDesign), addressing dissemination and exploitation.

assistant: **Impact**

Finely orchestrated protein activities are at the heart of the most fundamental cellular processes. The rational and structure-based design of novel functional proteins holds the promise to revolutionize many important aspects in biology, medicine and biotechnology. Computational protein design has led the way on rational protein engineering, however many of these designed proteins were solely focused on structural accuracy and completely impaired of function. DeNovoImmunoDesign proposes novel computational design strategies centered on the exploration of de novo protein topologies and the use of structural flexibility with the ultimate goal of designing functional proteins. The proposed methodologies aim to solve a prevalent problem in computational design that relates to the lack of optimal design templates for the optimization of function. By expanding beyond the known protein structural space, our approaches represent new paradigms on the design of de novo functional proteins. DeNovoImmunoDesign will leverage our new methodologies to design functional proteins with rational approaches for two crucial biomedical endeavors - vaccine design and cancer immunotherapy. Our strategy for vaccine design is to engineer structure-based epitope-focused immunogens to elicit potent neutralizing antibodies – a requirement for vaccine protection. The underlying basis of cancer immunotherapy is the inhibition of key protein-protein interactions - an arena where rational design is lagging. To meet this central need we will develop innovative approaches to design new protein binders for cancer immunotherapy applications. DeNovoImmunoDesign is a multidisciplinary proposal where computation is intertwined with experimentation (biochemistry, structural biology and immunology). Our unique
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tailoring and Extending Chemically-assisted Spinning to Textiles Incorporating Liquid crystal-Enhanced functionality' (TECHSTILE).

assistant: **Concept**

Responsive and smart textiles are a next frontier of research to add new, useful functionality to commodities we already use in our day-to-day lives. By allowing us to replace energy-consuming electronic sensors for detecting or responding to stresses and harmful conditions, they can contribute to a safer, greener, and more sustainable world. The jump from concept to product, however, has been fraught with issues: how can we incorporate novel materials of interest, such as liquid crystals or colloidal suspensions with a liquid armor functionality into fibers that we can then incorporate into textiles? In this project, I will use a microfluidic wet spinning technique I developed to incorporate functionality into fibers made from textile-grade polymers smart, yet comfortably wearable garments. I will focus on two functionalities: responsiveness to volatile organic compounds, enabled by liquid crystals, and responsiveness to ballistic impacts, provided by liquid armor. I will assess the performance of these fibers to the applied stresses as well as incorporate them, using embroidery and weaving, into fabrics and evaluate their performance in prototype wearable garments.


**Keywords:** fibers, spinning, liquid crystals, liquid armor, microfluidics, wet spinning, polymers, sensing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Virtual Man' (V-MAN) under Fifth Framework.

assistant: **Objectives**

The actual benefit will be a Software Developer Kit enabling the introduction of virtual autonomous or semi-autonomous characters in virtual environment. The SDK core classes for animating and controlling characters will include functions such as:- motion capture animation with retargeting and blending- the physics based animation module- order to action module which is a set of solvers including path planning- the conversational system with voice controlling and feedback.The SDK delivery includes a programming guide with commented examples of use. A demonstration and two applications are developed with this SDK. The testbed demonstration enables to use different commands (go there, sit, kick, etc.) while an example of film storyboarding and an escape demonstration relative to the building domain. This two last software will be developed by users to assess the toolkit possibilities along the project.