RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PREDICTION OF ALZHEIMER’S  DISEASE USING AN AI DRIVEN SCREENING PLATFORM' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Alzheimer’s disease (AD) and related disorders leading to dementia are associated with staggering costs and suffering. Recently, there has been some progress in the search for effective therapeutic interventions and it is clear that any treatment is likely to be most effective if administered at the earliest stage of disease, but the health care system is not ready for this new scenario. There is an urgent need, therefore, to establish scalable, cost-efficient diagnostic markers, tools and procedures that can identify people at increased risk, at point of care for stratification into personalized interventions to prevent or delay dementia. PREDICTOM will develop an open-source, interoperable and customisable biomarker screening platform, utilizing an existing online resource to save time and money, to generate an evidence base for general population screening for AD and related disorders. We will bring diagnostics closer to the patient by examining the feasibility of using samples which can be obtained at home (e.g. finger-prick blood, saliva (for genetics and epigenetics) and stool for microbiom) for diagnostic biomarker analysis. We will also evaluate innovative technologies for disease risk identification, including digital technologies and novel MRI, EEG, eye tracking, and blood-based biomarkers. The platform will use artificial intelligence models to analyse data from all biomarkers to identify users at high risk of developing dementia and to direct them to personalized intervention to prevent further cognitive decline and development of dementia. We will seek to facilitate a change in current healthcare practice for early diagnosis of AD  through development of new clinical practice guidelines based on evidence generated in the project. By improving the ease of id
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'RetinDR: The first topical ophthalmic formulation (eye drops) that effectively prevents and/or treats the retinal neurodegeneration induced by diabetes (diabetic retinopathy) and/or aging' to be submitted under Horizon 2020.

assistant: **Abstract**

Diabetic retinopathy (DR) is the leading cause of blindness among working-aged adults. About 93 million people worldwide and 3%-4.1% of Europeans suffer this disease. The early stages of DR usually have no symptoms, however when the disease progresses it affects vision: blurred vision, seeing double, difficulty reading, spots or floaters in the field of vision, and loss of peripheral vision. Current treatments are quite aggressive, are only indicated in advanced stages of the disease, have significant side effects and their effectiveness is limited. RetinDR is a topical ophthalmic formulation (eye drops) that effectively prevents and/or treats the retinal neurodegeneration induced by diabetes (diabetic retinopathy) and/or aging. The pharmaceutical development of RetinDR is based on the repurposing of the drug substance bosentan (endothelin receptor antagonist, currently indicated for the pulmonary arterial hypertension treatment) for the prevention and treatment of DR.The global DR market accounted for $5.81B in 2016 and is forecast to grow at 6.3%. CAGR till 2025. We estimate a market share of 0.115% 5 years after commercialisation, equalling revenues of 52M€. Our main business model will focus on sales and distribution of RetinDR in Europe through a distribution agreement with the parent company Medical Mix S.L. and co-development or licensing agreements with strategic industrial partners in markets outside of Europe where we will receive royalties.With this model and the successful completion of the SME Phase 1 and 2 we estimate an EBITDA of over 55M€ in 5 years after commercialization an IRR of 98% and NPV of over 21M€ considering a WACC of 15%, creating 22 new jobs by 2025. The Feasibility Study for this project will take 6 months and focus on an in-depth market st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'THE HYGIENE HYPOTHESIS : REVISITING THE CONCEPT BY INTEGRATING EPIDEMIOLOGY AND MECHANISTIC STUDIES' (HYGIENE).

assistant: **Concept**

The hygiene hypothesis postulating the paradoxical protective role of infections on immune-mediateddiseases including atopy (i.e. atopic dermatitis, rhinitis, asthma) and more recently autoimmune diseases hasbeen the matter of extensive investigation. The aim of the present project is to validate this hypothesisintegrating epidemiological and experimental studies.We will review in a meta-analysis published studies of direct and indirect markers of infections and atopicdiseases, and conduct a case-control study to analyse the association between infections and atopy usingatopic dermatitis as a prototypic model. This epidemiological study will assess the occurrence of differentinfections and other risk factors related to the incidence of atopic dermatitis in children under age five inItaly (300 cases and 600 controls).This epidemiological study will be supported by experimental approaches addressing mechanistic questionsraised by the hygiene hypothesis. Experimental models will include induction of acute and chronicbronchoconstriction/asthma, atopic dermatitis. In addition the project will aim at devising new mouse modelsof atopy. The nature of infections providing protection against allergic diseases will be investigated tocharacterise the difference at the molecular level between protective and non protective pathogens or theirderivatives. The underlying immune mechanisms notably homeostasis imbalance, antigenic competition,stimulation of regulatory immune cells and Toll-like receptor involvement will be analysed. In addition todeveloping integrated in vivo models, including the use of transgenic animals, efforts will be focussed on thestudy of available synthetic pathogen-derived compounds showing a protective activity to better approachtheir cellular and molecular mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'A doctoral training network in integrative studies of plant stress biology'.

assistant: **Concept**

The quality of human resources in science and technology ultimately underpins innovations and economic growth. Among the key areas with great socio-economic impacts, the resolution of important environmental issues, improvement of food quality and safety, and development of sustainable agricultural production heavily rely on the input from advanced research.In particular, research in stress biology of plants is central to achieving progress in these key areas. As basic instrument, interdisciplinary training of early-stage researchers directed towards specialization in these key areas is essential and requires the set-up of a Europe-wide integrated network of graduate schools, which are coordinated by institutions of scientific excellence with professional education practice.This need is addressed by proposing A Doctoral Training Network in Integrative Studies of Plant Stress Biology (ADONIS), which offers a multidisciplinary Ph. D. program in biology, botany, physiology, genetics, functional genomics, advanced proteomics, molecular breeding, mass spectrometry, biotechnology and bioinformatics. The major scientific program is to unlock the biological processes that allow plants to tolerate unfavourable environmental conditions.This integrated program is based on a close collaboration between universities and research centres of excellence from eight European countries. ADONIS offers outstanding resources and unique opportunities for young researchers to develop their research carriers by undergoing intensive training, developing strong complementary skills in scientific communication and project planning, and gaining insight into practical developments and global job opportunities.ADONIS secures a wide range of scientific qualifications monitored by international benchma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Edaphic adaptation in barley wild relatives and its transfer to the domesticate' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Wild relatives of domesticated plants have long been recognized as important sources of beneficial traits for crop improvement. Having diverged millions of years ago from the domesticate, they have evolved adaptations to more diverse habitats, potentially representing a much wider genetic diversity than could be captured by intraspecific diversity in a crop and its direct wild progenitor. However, concomitant sequence and karyotype divergence have made crop-wild relatives inaccessible to the cross-and-select cycles of traditional breeding. Thus, the main obstacles to transferring beneficial traits from wild relatives have been the lack of effective methods for gene isolation and fertility barriers. The technological breakthroughs in high-throughput sequencing, genome mapping and genotyping have brought to wild species a full-fledged toolkit for linking genotype and phenotype, namely quantitative trait locus mapping and genome scans in natural population. At the same time, new biotechnological approaches have obliterated the need for overcoming crossing barriers: discrete genetic factors controlling adaptive traits can be isolated in the wild relatives and then transferred into the domesticate by gene editing. Exploiting these innovations, this project aims at understanding speciation and edaphic adaptation in three closely related wild relative of barley from South America. We will elucidate the genetic basis of salt tolerance and transfer it into the domesticate. Our specific aims are to (i) develop a genomics toolbox for a complex of three Hordeum species from Patagonia; (ii) understand the interplay of speciation, adaptation and patterns of sequence diversity by population genomic analyses; and (iii) isolate genes involved in adaptation to saline soils and transform
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Design for future needs' (DFFN).

assistant: **Innovation**

This proposal is to conduct research into the tools, techniques and methodologies, used in design forecasting practice in different industry sectors and in different geographical areas of the EU. These techniques, used to anticipate the needs of the future population, will enhance planning and foresight initiatives in industry, the public sector and governmental policy throughout the EU. The project consists of a study of current design forecasting practices, documentation of three case studies and definition of social, industrial and economic themes and trends. The results will be a report and website which describes the value of design forecasting practices to foresight initiatives to enhance our ability to anticipate needs and generate innovative proposals that will contribute to our future quality of life.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ON-DEMAND CONSULTING AND REMOTE ELECTRONIC - TRAINING FOR SMES IN URBAN & RURAL AREAS' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

ICARE 9000 helps small and medium-sized enterprises (SMEs) use modern telematics to attain quickly and economically the recognised European quality standards (EN29000 and ISO9000) needed for international competitiveness. The project aims to improve the access of SMEs in less-favoured areas to ISO9000 training courses, the follow-up of information and to offer telematics advisory support to quality engineers for whom regular travel to traditional courses is costly and time-consuming.The ISO9000 norm for the management of quality have been first developed by the International Standardisation Organisation and are now accepted as an European norm within the EN29000 series. Market forecasts clearly show that the number of certificates will drastically increase in the following years. In 1996/1997, 20 % of European companies are expected to have or to be in the process of getting the ISO9000 certificate. In addition to the marketing plus-value", the ISO certificate guaranties a quality insurance presenting the following advantages:- it conforms to internationally accepted standards- it provides the ground for a permanent quality improvement- it facilitates the production of proof in the context of product liability- it reduces the fixed costs and the costs resulting from products' and services' quality failures.To prepare themselves for the ISO9000 certificate, the Small and Medium sized Entreprises (SMEs) require external help in the form of consulting and/or upgrading the skills in the quality engineers of the quality department (if present).Attending courses is time consuming because most of the SMEs are widely dispersed and several journeys are necessary to complete the certification process. It is not cost-effective : the travel introduces high costs and loss of time fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Iron speciation in the microenvironment surrounding phytoplankton cells and the consequences for Fe bioavailability' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The interaction between metals and microscopic plant-like organisms called phytoplankton is a key link to global carbon balance. More than a half of atmospheric CO2 on earth is taken up by phytoplankton, but iron (Fe) limits their growth in large regions of the oceans. Ongoing ocean acidification and global warming will influence Fe-stress in marine phytoplankton and hence the biological carbon fixation. Key existing knowledge gaps are the pathways by which phytoplankton take up Fe, and influences of chemical conditions in the microenvironment surrounding algal cells (i.e., phycosphere) on Fe speciation and bioavailability. This knowledge represents an impediment to understanding the complex effects of climate change on Fe uptake and oceanic carbon fixation. The project ‘Phycosphere Fe’ will determine chemical conditions and Fe speciation in the phycosphere of model phytoplankton species, quantify the role of phycosphere Fe speciation in Fe bioavailability, and investigate influences of climate change (i.e., warming and increased CO2) on Fe-algae interfacial processes. The project is key to the assessment of Fe bioavailability, growth and CO2 fixation of phytoplankton in current and future oceans, which make key contributions to global carbon sequestration. The project will improve our ability to model phytoplankton dynamics and predict biological carbon fixation in a changing ocean.


**Keywords:** trace metals, bioavailability, metal speciation, algae, phytoplankton, uptake
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The revolution of the Compression Therapy Market: an easy-to-wear and comfortable compression stocking based on Electro-Active Polymers technology.'.

assistant: **Objectives**

ComFyt is a novel compression therapy stocking employing a proprietary material which eliminates the discomfort and the difficulties of traditional compression stockings. ElastiMed has identified the potential of the technology in the method of manufacturing and processing Electro-Active Polymers (EAP). The material is a soft plastic, constructed flat, with large deformation and linear activation being a unique solution, optimal for wearable devices.  These actuators are able to mimic the rhythmic natural calf muscle contractions, leading to the optimal blood circulation, representing a breakthrough in the Compression Therapy.Compression Therapy is based on a mechanical principle of applying a constant or intermittent pressure on the lower limbs using a wearable sleeve or stocking. Despite the many treatment options available, the market is suffering from a low compliance rate and continues to seek innovative solutions that will reduce patient’s discomfort, decrease hospitalization stay, and improve the patient quality of life. Venous and lymphatic diseases such as Venous Thromboembolism (VTE), Chronic Venous Insufficiency (CVI), Deep Vein Thrombosis (DVT) and Lymphedema affect a large population worldwide. Age, gender, heredity, pregnancy and lifestyle are conditioning factors. Pain, mobility difficulties, reduced self-esteem, social isolation, disability to work, altered body image and depression affect the quality of life of the elderly and in general of people coping with venous and lymphatic diseases.  Yearly, there are approximately 10 million cases of VTE worldwide. VTE-related events kill more people than AIDS, breast cancer, prostate cancer and motor vehicle crashes combined in Europe and U.S. A growing elderly and diabetic population are also key components in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Rescue Pacing for Congenital Complete Heart Block'.

assistant: **Innovation**

Congenital heart block is the most commonly observed type of foetal bradycardia, occurring in one in 15.000 live births. A significant subset of foetuses develops towards congenital complete heart block (CCHB), i.e., complete failure of the electrical excitation wavefront to be conducted over the atrioventricular (AV) node. CCHB is the most severe and life-threatening cardiac arrhythmia in utero. Current medicinal treatments cannot significantly alter the cause of CCHB and therapeutic attempts at human foetal cardiac pacing have been unsuccessful. For CCHB patients at high risk for life-threatening disease progression and death due to severe bradycardia before 34 weeks of gestation, this project develops a gene therapy medicinal product (GTMP) that is based on adenoviral vector-mediated ion channel overexpression, to transiently increase heart rates over the course of several months. When successful, such a GTMP would rescue these patients and allow for permanent pacemaker implantation in the first months after birth.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'the Study of Orthographic Learning' in the context of a Horizon 2020 call.

assistant: **Objectives**

Literacy acquisition can become a developmental bottleneck for a significant percentage of otherwise-competent children, preventing them from adequate progress in education. One key concept which is both, crucial to attain literacy proficiency, yet a severely understudied topic, is Orthographic Learning (OL). OL refers to the transition that a written word makes from being initially unfamiliar to becoming familiar, so that the word can be spelled accurately and read automatically. However, there are reasons to believe that, contrary to current OL theory, the skill of learning how to spell a word (OL-Spelling) might not be related to the ability to automatise the reading of a word (OL-Reading). This would result in a drastic revision of literacy acquisition theory. Therefore, the main scientific aim of the Study of Orthographic Learning (SOL) is to clarify whether there is a single OL system or two independent OL systems. To meet this goal, SOL will carry out two studies. Study 1 (Cádiz and Gibraltar) will 1) assess to what extent does OL-Reading correlate with OL-Spelling, 2) examine whether the cognitive predictors of OL-Reading and OL-Spelling differ, and 3) explore how the interaction between orthographic depth (English vs. Spanish) and OL clarifies whether there is one or two OL systems. Profiting from cutting-edge neuroimaging technology, Study 2 (BCBL, San Sebastián) will assess if the neural correlates of OL vary depending on the type of OL being assessed. Moreover, one H2020 cross‐cutting priority and two Europe 2020 Flagship Initiatives are i) promoting fairness in education from an early age, ii) contributing to creating an excellent education system and iii) preventing school-failure by improving literacy early on. Adopting an interdisciplinary approach, SOL