RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PHYtoplankton responses to organic COntaminants: the role of CYtochrome P450' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Anthropic activities result in a continuous release of Organic Contaminants (OCs) in the aquatic environment and chemical pollution may considerably affect phytoplankton that are photosynthetic microorganisms playing a major role in aquatic ecosystems. Adverse outcomes of OCs on phytoplankton are directly linked to the ability of the organism to face the toxic insult. OCs may be metabolized to less toxic compounds activating poorly understood biotransformation processes. The main objective of the PHYCOCYP project is to improve the mechanistic understanding of biotransformation processes and their role in phytoplankton tolerance to OCs. Among the numerous enzymes involved in xenobiotic biotransformation, a key role is played by Cytochrome P450 (CYPs). CYPs are found in all domains of life and were extensively studied in higher organisms. However, little information is available on the role of CYPs in OC biotransformation and tolerance in phytoplankton. The PHYCOCYP project will address this knowledge gap. Recent genomic studies highlighted the presence of multiple CYP genes in phytoplankton species and toxicological studies indicated their involvement in phytoplankton responses to OC exposure. In the proposed research, an initial screening will investigate whether CYP genes expression is conserved in different phytoplankton classes exposed to OCs with different modes of action. The involvement of CYPs in OC biotransformation and tolerance will be then assessed in a model phytoplankton specie integrating a genetic approach to physiological investigations and metabolic profiling of OC transformation products. Aquatic environment preservation and restoration is one of the main contemporary environmental challenges. Knowledge generated with PHYCOCYP project will help evaluat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Metaphysics of identity, properties, and relations in fundamental physics' to be submitted under Seventh Framework.

assistant: **Abstract**

This project belongs to the category of philosophical reflection on the metaphysical consequences of contemporary physical theories. The metaphysical problems that are to be considered concern the analysis of the fundamental notions of objects, identity, individuality, and properties. The central question regarding these concepts is whether and how the numerical distinctness of objects can be grounded in the differences in their qualitative properties. In the light of the recent arguments against the validity of the Principle of the Identity of Indiscernibles within the quantum theory of many particles, it is now common to seek the metaphysical grounding of numerical distinctness in the entire relational structures comprising the objects in question. Alternatively, the hypothesis of the primitive character of numerical identity and distinctness is considered. The project will attempt to investigate these metaphysical issues in the context of a broad range of modern physical theories, including non-relativistic quantum mechanics, relativistic quantum field theory, general relativity, and quantum gravity.  Particular attention will be paid to the notion of quantum entanglement and its numerous metaphysical consequences regarding the individuality of objects, the intrinsicness of their properties, and the supervenience of whole structures on individual objects and their properties. The hypothesis of ontic structural realism, with its emphasis on the ontological priority of relational structures over their relata, will be put to the test taking into account the recent developments in fundamental physics. This project is an interdisciplinary undertaking, combining a general metaphysical framework with logical and formal tools and concepts derived from fundamental physical th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '5mw innovative wind turbine suitable for on land and offshore installations', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

INNOWT5000 aims to cover the following objectives:1. To design, manufacture and install a 5MW wind turbine (extendable to 5.5MW) suitable for offshore as well as for on land installations.2. To develop products and procedures to overcome the barriers of transport and erection of MW class wind turbines3. To respect the environment fully in line with the European directives, in every aspect, by adopting different philosophy and increased used of new and environmentally friendly materials and by incorporating it in every process of the manufacturing, transport, installation, operation and maintenance phase.4. To reduce the electricity production costs by optimising the design to competitive levels, i.e. targeting to electricity production costs at below 0.035/kWh when the machine will be marketed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unlocking the potential of comammox Nitrospira for sustainable wastewater treatment' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Nitrogen (N) pollution contributes to the triple planetary crisis of climate change, nature and biodiversity loss, and pollution and waste. Sustainable nitrogen management is, therefore, urgently needed. To this end, nitrogen removal from wastewater plays a key role. Current N removal technologies suffer from high energy consumption and greenhouse gas (nitrous oxide) emissions, underscoring the need for more sustainable and efficient nitrogen removal technologies. The UniCoN project aims to unlock the potential of recently discovered complete ammonia oxidizing (comammox) bacteria for more sustainable and efficient N removal from wastewater. To achieve this, I will employ a multidisciplinary approach of integrating engineering principles with multi-omics analyses and advanced modeling techniques to 1) first provide a comprehensive physiological and kinetic characterization of diverse comammox bacteria; 2) foster their synergistic partnership with other microorganisms to develop a novel process in biofilm reactors; and 3) identify optimal system configurations and operational strategies to harness the potential of comammox bacteria in future and existing wastewater treatment plants. The anticipated results will 1) enable novel sustainable biotechnologies with the potential of complete N removal and zero nitrous oxide production, 2) improve existing engineered applications of biological nitrogen removal, and 3) deepen our understanding of the importance of comammox bacteria both in natural and engineered systems. This project’s interdisciplinary nature will also allow me to expand my expertise in molecular biology while combining my expertise in process engineering and mathematical modeling with the host.


**Keywords:** Wastewater treatment, Nitrogen removal, Anammox, Nit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advancing Sustainable Fisheries and Marine Ecosystem Conservation in the Atlantic and Arctic Sea basin' to be submitted under Horizon Europe.

assistant: **Abstract**

MarineGuardian will, through a holistic approach, provide impact-driven solutions to reduce fisheries´ environmental impacts on marine species and habitats in line with the Common Fisheries Policy, Marine Action Plan, EU 2030 Biodiversity Strategy and Marine Strategy Framework Directive. The seafood sector contributes to global food security, but is largely unsustainable, with 38% of fish stocks overexploited and significant ecological implications. 79% of EU’s coastal seabed habitats are disrupted, and a quarter lost, mainly due to intense bottom trawling. Current solutions for more sustainable fisheries exist but are fragmented and often lack real-time actionable insights for fishers and policymakers.MarineGuardian will advance tools, technologies and operational strategies, and enhance knowledge to accelerate the transition towards sustainable and economically viable fisheries. The project will deliver: 1) innovative technologies to reduce and prevent incidental catches of sensitive species and juveniles, 2) best practice guidelines for reduced discard and damage to catch, 3) decision support systems for effective mitigation measures to protect sensitive marine ecosystems, whilst optimising fishing operations, 4) new methods for data sharing in seafood value chains to ease corporate sustainability reporting and ecolabelling processes. These will be co-developed with fishers, management authorities, and policy makers, tested in 6 case studies to demonstrate their feasibility and ensure long term viability of the European seafood sector. A roadmap for sustainable fisheries will be drawn-up to demonstrate scalability and replicability of the solutions in line with the Mission Ocean objectives. The consortium holds the cross-cutting knowledge and expertise within private
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Non invasive Cell Based Liquid Biopsy Platform for Bladder Cancer' (OneRNA4Bladder), addressing dissemination and exploitation.

assistant: **Impact**

OneRNA4Bladder aims to save lives and reduce cost of care for bladder cancer treatment – the most expensive type of cancer to treat due to expensive diagnostic procedures and ineffective drugs leading to a recurrence rate of 70%. Implementing the OneRNA4Bladder system for bladder cancer recurrence detection could cut the cost of managing bladder cancer in half, resulting in savings of more than €800 million/year in EuropeThe key project technology is a patented Urine Cancer Cell Filtration Device (UCCFD) that enables the selection of tumor cells from a simple urine sample. The UCCFD was developed and validated in a small prospective clinical study by the Danish Cancer Society and in-licensed by Genomic Expression Aps (GEx). In OneRNA4Bladder, GEx aims at the clinical validation of the UCCFD – in combination with DNA biomarkers – for the detection of bladder cancer recurrence. Furthermore, the UCCFD can – in combination with GEx’s proprietary OneRNA™ platform, which links RNA's to drugs that can provide a more effective treatment – be applied as a liquid biopsy platform to monitor the disease response to treatment without invasive biopsies or cystoscopies. In OneRNA4Bladder, we will also clinically validate the UCCFD technology together with OneRNA™ as a liquid biopsy platform. OneRNA4Bladder is an opportunity for GEx to enter the world-wide bladder cancer diagnostic market. The accomplishment of the project objectives will represent a significant business opportunity for the SME, with expected sales of over €165 million within 5 years of launch.


**Keywords:** bladder cancer, recurrence, urine cancer cell filtration device, DNA, RNA, non-invasive, cost, reduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identifying the factors leading to pregnancy-induced remission in a model of Multiple Sclerosis', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Multiple Sclerosis (MS) is a major pathology that is typically associated with central nervous system inflammations, demyelination and axonal loss. MS has a major economical impact on health care systems since it has currently no available cure. This pathology presents a clear sexual difference since women are representing over the two thirds of MS patients.However the clinical outcome of women with MS is better than the one for men. It has been suggested that sexual steroid hormones play a role in this potential protection since women with remitting-relapsing form of MS undergo remission during the last trimester of pregnancy. This effect is more beneficial clinically than any effect induced by current pharmaceutical treatments. Studying remission induced by pregnancy is extremely relevant to understand the mechanisms involved in MS remission and for its potential to identify factors that may be developed as new therapeutic compounds.The major goal of this project is to investigate through in vivo and gene array strategies, the cellular and molecular mechanisms underlying the protective effect of pregnancy in an experimentally induced murine model of MS. The first objective is to determine the specific parameters (i.e. inflammation, demyelination, or axonal loss) that are specifically modulated in vivo during pregnancy-induced remission. The second objective is to identify, through gene array analysis, factors that are specifically regulated during remission and that are involved in this mechanism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'International Fellowship Programme for Talent Attraction to the Campus of International Excellence Campus Iberus' (IberusExperience) under Horizon 2020.

assistant: **Objectives**

The proposed MSCA COFUND FP “IberusExperience - International Fellowship Programme for Talent Attraction to the Campus of International Excellence Campus Iberus” is promoted by Campus Iberus, a strategic partnership which brings together four high-profile research universities from four different regions along the Ebro valley in northeastern Spain: Universidad de Zaragoza, Universidad Pública de Navarra, Universitat de Lleida and Universidad de la Rioja. IberusExperience tables a competitive and attractive research environment of inter-connected regions and universities, bringing together 4 recruiting universities and a total of 88 academic and non-academic partner organisations from 26 countries committed to host secondments and/or to offer trainings, networking events and others actions to enhance the career opportunities of the researchers.  IberusExperience will offer 11 positions for worldwide excellent Experienced Researchers (ER) who are willing to develop individual and free-choice innovative research projects for a period of 36 months in any of the five areas of specialisation of Campus Iberus: 1) Agro-food & Nutrition; 2) Health Technologies; 3) Energy, Environment & Sustainability; 4) Social & Territorial Development; 5) Circular Bio-Economy.The IberusExperience Programme is planned to start on July 2021 and last for 72 months. It involves one call for applicants and the evaluation of the research proposals by international independent experts. The recruitment of the 11 talented researchers is expected to be achieved before M18. The programme is not just aimed at talent attraction but consolidation and retention. Researchers will have the opportunity to be extensively trained in research and transferable skills and consolidate their professional careers at th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transcriptional mutagenesis in mammalian cell systems: p53 signaling as a probe of cellular effects' (TMP53COMPMIX), addressing dissemination and exploitation.

assistant: **Impact**

The process of misincorporation of incorrect bases into the nascent RNA as a result of DNA-lesion bypass by RNA polymerases during transcription is referred to as transcriptional mutagenesis (TM). Although this has been shown to alter the subsequent proteins function, the relative importance of TM in human health is virtually untouched. I propose to study the cellular effects and biological significance of TM using the tumor suppressor protein p53 as probe. The choice of p53 is based on its role as a guardian of the genome regulating life or death of cells. The objective will be achieved by developing novel expression constructs containing site-specific DNA damage yielding transcripts encoding mutant p53 protein. This will in part be done in a continued collaboration with my former post doctoral mentor at New York University, USA. The vectors will be transiently transfected into mammalian cells and the TM of p53 and the cellular effects on e.g. cell-cycle progression and viability studied. Furthermore, cellular model system will be utilized to study the potential effects of TM on the cellular response to a toxic insult. The model is based on the central role of p53 in the cellular response to DNA damages derived from carcinogenic polycyclic aromatic hydrocarbons (PAHs). Transfected cells exposed to complex PAH mixtures will be assayed with regard to relevant endpoints including; p53 down-stream signaling events and expression, cell cycle regulation and DNA repair. The results will be analyzed in relation to the p53 protein status. The use of PAH mixtures is motivated by the increasing interest by the European community in developing strategies for risk assessment of complex mixtures. The proposed project will take place at Karolinska Institutet, Sweden, ranked as one of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A quantitative model for the residual macro stress development during plasma nitriding' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Plasma nitriding is an environmentally harmless surface engineering technology which is being rapidly accepted by the European manufacturing industry. During plasma nitriding a residual macro stress profile develops and important design parameters like load bearing capacity and fatigue strength are sensitive to residual stresses.  The objective of this project is to develop, in cooperation with the surface engineering group of the University of Birmingham, a quantitative model for the residual stress profiles arising from the plasma nitriding process.  During the plasma nitriding process there are two unknown parameters, stress relaxation and the redistribution of carbon. The present project will involve the measurement of the kinetics of these parameters together with accompanying microstructure analysis. Carbon redistribution will be measured for a set of nitriding parameters and the influence on hardness on a 'fine scale' will be measured using nano-indentation techniques. These data will be correlated with experimental residual stress profiles and will be mathematically modelled using a variety of numerical techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Reaction products of chlorohydroxyfuranones and base units in dna' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

It is well recognized that extracts of most drinking water disinfected with chlorine show mutagenic activity in the Ames Salmonella assay. Chlorohydroxyfuranones (CHFs), and specially the compound MX (3-chloro-4-(dichloromethyl)-5-hydroxy2(5H)-furanone), account for a significant part of this mutagenicity. The objective of the present work is to investigate the formation and identify adducts produced in the reaction of DNA with CHFs. The previously published and on going studies on adducts identification by Kronberg et al. provide clues on adducts likely to be formed in DNA. Identification of the adducts are based on comparison of HPLC retention times, UV- and mass spectra with those of known adducts. 1H- and 13cNMR are used to identify unknown adducts. We will also develop a GC-MS method for adduct identification (complimentary to the HPLC-UV method). If sensitive enough, such a method could enable analysis of adducts in various tissues of test animals exposed to CHFs.