RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rerouting mRNA for in vivo chimeric antigen receptor immune cell therapy' to be submitted under Horizon Europe.

assistant: **Abstract**

Chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer treatment. Nevertheless, CAR T cell therapy is clinically limited to hematological malignancies and hampered by its complex and costly ex vivo manufacturing procedure. To render this treatment cost-effective and available for diverse cancer types, in vivo CAR immune cell therapy strategies must be developed. My group has established new apolipoprotein nanoparticle (aNP) platform technology for RNA delivery to immune cells. Leveraging lipoproteins’ natural delivery features, our technology combines tunable biodistribution features with a superb biocompatibility profile. Building on this concept, I propose developing aNPs containing messenger RNA (mRNA) encoding CARs to be delivered and expressed by specific immune cells.Based on compelling preliminary data, I will pursue two Key Objectives:KO1: Using advanced microfluidic production methods, we will establish a library of self-assembling aNPs – composed of natural phospho(lipids), ionizable cationic materials and apolipoprotein A1 (apoA1), and containing mRNA – and screen barcoded aNPs’ ability to functionally deliver mRNA to immune cells in vivo. Machine learning analysis will provide lead formulations for in vivo CAR monocyte/macrophage (CAR M) proof-of-concept therapeutic studies in a solid tumor mouse model.KO2: Using proprietary apoA1-nanobody fusion protein technology, we will screen targeted mRNA-aNPs’ ability to induce functional gene expression in specific immune cells in vivo. Lead aNP-mRNA formulations will be used for in vivo CAR T proof-of-concept therapeutic studies in a hematological mouse tumor model.This Program’s successful completion will yield a unique, versatile nanomedicine approach that can be employed to induce in vivo CAR im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering regulatory principles of proteasome heterogeneity and the degradation landscape in cancer' (2021-2027).

assistant: **Concept**

Proteasome activity is crucial to removal of defective or obsolete proteins, cell signaling and antigen presentation. In cancer, proteasomal degradation was shown to play key roles in tumor growth, antigenicity and response to immunotherapy. Yet, comprehensive analysis of proteasome subunit composition and the degradation landscape in cancer has not been performed to date, rendering our understanding of inter-patient proteasome heterogeneity and proteasome-dependent mechanisms underlying tumor-immune interactions far from complete. Our novel, unbiased approach, MAPP, for MS Analysis of Proteasome-cleaved Peptides, is ideally suited to examine the missing link between cellular degradation and cancer immunity. We have already demonstrated its utility in identifying degradation events associated with inflammation, proteasome cleavage, substrate alterations and an anti-inflammatory role of the proteasome subunit PSME4, in lung cancer. We aim to capitalize on our powerful analytical methods, vast experience and preliminary data and  develop further our cutting-edge technology, to shed light on the uncharted area of degradation pathways in cancer. We plan to: (1) Characterize both proteasome composition and the degradation landscape across cancer types and develop MAPP further to enable in vivo, tissue-specific, and proteasome-type-specific profiling. We strive to provide a near complete narrative of proteasome activity and distribution in tumors and their role in shaping tumor-immune interactions. (2) Study proteasome-dependent mechanisms underlying tumor immunogenicity and response to immunotherapy at the biochemical, cellular and physiological levels.(3) Exploit inter-patient proteasome heterogeneity for translational opportunities, in particular as an adjunct to current i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanoscale Electrochemistry on Light Metallic Alloys' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This proposal presents unique approaches for the characterization of light metal (magnesium as an exemplar throughout) alloy interfaces at the nanoscale in aqueous media, through the implementation of innovative, quantitative high-resolution scanning electrochemical probe microscopy techniques. The overarching goal is to introduce new methodology that will enable a comprehensive understanding of the influence of nanoscale inhomogeneities in the dissolution of light metal alloys. The scientific scope of this project involves: (i) determining the behaviour of different individual single entities (such as grains, grain boundaries, inclusions) on the heterogeneous surfaces of Mg-based alloys at the nanoscale, isolated from the rest of the surface (ii); progressing to the visualization of interacting surface sites and associated reactive fluxes during alloy dissolution; and (iii) nanostructuring at the nanoscale, as a new way for the rational study of surface treatments to improve alloy durability, which are of fundamental and technological (e.g. structural application bodies, bioimplants, batteries etc.) importance. The research proposal is highly interdisciplinary, and there is a natural synergistic fit between the Fellow’s profile and activities at the Host Warwick group. The project brings together the considerable expertise of the Fellowship applicant in light metal alloys and corrosion with that of the Host group in frontier correlative electrochemical microscopy to create new approaches that will greatly advance this important field. With considerable support and world-class expertise from the Host group and its collaborators, this project will provide the applicant, Dr. Viacheslav Shkirskiy, with an outstanding opportunity to develop personally and professionally, by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Theoretical studies on linear optics quantum network with atoms and photons and its experimental realization'.

assistant: **Concept**

In this project we will carry out theoretical studies on the feasible realization and the potential applications ofquantum network with photons (ideal for long-distance information transmitting) and atomic ensembles (ideal forlong-time information storing) . Based on several recent advances in the field, we will propose a feasible way ofcreating high-quality entanglement for quantum network with many atomic ensembles (AEs). The goal ispromising by (1) choosing AEs with suitable atomic level structure, (2) us ing linear optics elements (manipulatingphotons with very high accuracy), and (3) adopting the two-photon scheme (robust entanglement creation,without the stringent requirement of long-distance phase stabilization). Our scheme would significantly facilitat ethe experimental realization of the AE quantum network with high-quality entanglement. By using AEs, we willintegrate within our proposal the existing schemes for storing quantum states of photons and for high-efficiencyphoton counting, thus realizing all ingredients required for a long-distance quantum communication within asingle scheme.The proposed project represents interdisciplinary, challenging, yet promising scientific aims. The host grouphas extensive experimental expertise in AEs, while the applic ant has extensive experiences in the relevanttheoretical topics that are required in the project. Both the host and the applicant will mutually benefit from thecombination of their complementary knowledge in experimental and theoretical aspects. This is po ssible only bythe mobility and professional experiences in several groups in this novel field, which is important for the futuredevelopment of the applicant as an independent researcher. We anticipate that novel scientific resultsaddressing in our proposal wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mediterranean and trans-european networks for transport' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The project propose a concentration process between all stockholders in order to promote a common understanding of transport infrastructure problems and issues adapted to European -Mediterranean context (interconnectivity and interoperability) and to better integrate EU and Mediterranean transport networks. Starting from the assessment of performance of the present transport networks and previous studies a common reference framework of analysis is built including an identification methodology of major corridors. Infrastructure projects will be analysed in relation to the operating rules and accompanying measures. Tools and criteria will be consolidated through mutual exchanges and capitalisation of data as well as development of case studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Engine LUBrication SYStem technologies' (ELUBSYS).

assistant: **Concept**

In aeronautics, gas turbine engines are equipped with lubrication systems whose function is to cool and lubricate the highly loaded rolling bearings and gearboxes. Current lubrication systems are based on architectures and technologies that have not much evolved for the last 30 years and that, despite advances made on components, have reached their technological limit. Future aero-engine requirements cannot be met neither by state-of-the-art lubrication systems nor by incremental improvement. ELUBSYS will design, develop and validate innovative technologies and architectures for aero-engine lubrication systems targeting increased efficiency and reduced cost, mass and engine Specific Fuel Consumption (SFC). The primary focus is around new brush seal technologies that offer the potential to improve engine propulsive efficiency by reducing bleed air losses whilst withstanding the aero-engine’s harsh environment. ELUBSYS will investigate the performance and endurance of brush seals; assess their impact on the thermal efficiency of lubrication systems and their external components and on oil quality. A secondary focus is the wider lubrication system including vent, scavenge, bearing chamber modelling and oil behaviour. Main objectives of the project are to: - Reduce engine SFC and related CO2 emissions by reducing by 60% the requirement for bleed air from the engine to seal the bearing chambers and by improving the thermal management of bearing chamber housings and ports - Reduce engine oil consumption by 60% - Optimise the architecture and performance of lubrication systems and thereby reduce their complexity and mass - Develop solutions to improve monitoring of engine oil quality and prevent coking in the lubrication system These goals will be achieved by a European consor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Linkages of elements in soils and plants with mycorrhizae along Philippine and pantropical elevational gradients'.

assistant: **Innovation**

Tropical mountains are biodiversity hotspots where a zonation of biota occurs with environmental conditions as one ascends. Patterns of vegetation types are well documented, as is the decline of plant-available nitrogen (N) relative to phosphorus (P) with elevation. However, how absolute and relative availabilities of essential elements beyond the well-studied N, P and carbon (C) vary in such mountains remains poorly understood, despite evidence that base cations and micronutrients do indeed affect tropical forests’ and other ecosystems’ functioning. Potentially important but overlooked factors that may confound elevational patterns of elemental availabilities are the type, dominance and abundance of mycorrhizal fungi, which in turn are also affected by biogeochemical cycling, directly or through shifts in vegetation. Here, I address these knowledge gaps by investigating patterns of C, N, P, potassium (K), calcium (Ca), magnesium (Mg) and micronutrients, and their association with mycorrhizae across three distinct Philippine tropical mountains. While fungal and particularly plant biodiversity in these areas are well documented, biogeochemical patterns remain largely unexplored. PHILANTROPIC-ELEMYCO will test the hypothesis that absolute and relative availabilities of these elements are associated with both elevation and mycorrhizae. Specifically, the project will (1) analyze concentrations and stoichiometry of species- and community-weighted leaf, litter and soil elements along elevational gradients, (2) assess the co-occurrence thereof with association type, abundance and diversity of mycorrhizae, and (3) conduct a systematic review comparing mycorrhiza-nutrient relationships among tropical regions. By uniquely integrating expertise and approaches from tropical forest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The evolution of antibiotic resistance: integrating molecular mechanisms of resistance and evolutionary context'.

assistant: **Concept**

The evolution of antibiotic resistance poses an important threat to human health and welfare. Antibiotic resistance is accompanied by fitness costs that have been shown to play a key role in the spread of resistance. These costs are variable, but the underlying ecological and genetic causes of this variation remain obscure. Unfortunately, bacteria can adapt to the cost of resistance by compensatory mutations, and this permits resistance to be maintained in pathogen populations after antibiotics have been withdrawn from use. Resistance mutations vary in their potential for compensatory adaptation, but the causes of this variation remain unknown.  In this project, we will determine how the molecular mechanisms of antibiotic resistance and the (i) ecological and (ii) genetic context in which resistance evolves interact to determine (a) the fitness costs associated with antibiotic resistance and (b) the potential and mechanisms for adaptation to the cost of resistance. Conceptually, we will approach this problem using an interdisciplinary approach that combines theory from population genetics and systems biology into the same evolutionary framework. To carry out this research program, we will use high-throughput experimental evolution of resistance to the broad-spectrum antibiotic rifampicin in bacteria from the genus Pseudomonas. This research approach will allow us to measure both the costs of resistance and the (i) rate and (ii)  mechanisms of compensation for this cost at an unprecedented scale. The results of this research program will provide key insights into the underlying drivers of resistance emergence and persistence, and it may ultimately be possible to apply the insights from this research program to help combat resistance in pathogen populations. At a more con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel Superfluids in Ultracold Fermionic Mixtures'.

assistant: **Objectives**

The intricate mechanisms leading to superfluidity and superconductivity have fascinated researchers for many decades. The pairing of fermionic constituents is at the heart of a rich class of related phenomena in quantum matter. The understanding of unconventional regimes of superfluidity, such as broken-symmetry systems with finite-momentum pairs, poses great challenges for theory and experiment.Our experimental approach is based on a new ultracold model system, which has become available very recently, following a breakthrough in our laboratory. We combine two fermionic isotopes with different masses (Dy-161 and K-40) to create a quantum-degenerate Fermi-Fermi mixture. The system features the key ingredients required for creating novel strongly interacting superfluids: mass imbalance, tunability of interactions, and collisional stability. At present, our Dy-K system represents the only experimentally available Fermi-Fermi mixture that offers this combination of properties.The key point is that, according to theoretical predictions, mass imbalance favors unconventional regimes of superfluidity. In contrast to the widely investigated ultracold fermionic spin mixtures (systems with equal masses), the regions in the phase diagram for unconventional phases are much larger and appear at temperatures that can be realistically achieved in experiments.We will realize strongly interacting Fermi-Fermi superfluids and investigate the various regimes of superfluidity with the ultimate prospect to demonstrate symmetry-broken phases. For this purpose, we will generalize the methods developed for spin mixtures, and we will develop new species-selective optical traps. We will carry out our main research on the Dy-K system, but we will also push the limits of mass-imbalanced systems by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Airport detection and Tracking Of dangerous Materials by passive and active sensors arrays' to be submitted under Seventh Framework.

assistant: **Abstract**

The overall objective of project is to contribute to improve the security in the airport area and, thus, on board of departing aircrafts by: • detecting and identifying, without interfering neither with the normal passengers flows, nor with the normal airport operations, the presence of hazardous materials or tools, concealed (under clothes or inside bags) by ill-intentioned people circulating inside airports and that could deliver attacks; • tracking the movements of those threatening people concealing those forbidden items, so that they can easily be localized by security operators. The project intends to study, design and develop the functional prototype of an innovative multi-sensor based system integrating active and passive radar sensors, able to survey wide airport areas without requiring the passengers cooperation by detecting hazardous materials/tools and tracking threatening people or containers; the system will increase the security level not only in the gate area (behind metal detector), but also at a preliminary stage, starting from the airport arriving/departure halls. The approach to be followed foresees two separate and integrated controls: 1. one at the Terminal accesses (between sliding or revolving doors, etc ..) equipped with innovative active devices, not interfering with passengers transit and able to detect and identify dangerous tools (guns, knifes, non-metallic weapons, explosives, etc.) concealed under clothes or inside bags, without requiring passengers to remove their clothes or to empty out their bags; 2. the other in the airport halls before the gate area equipped with new passive RF sensors not interfering with passengers transit and able to track suspicious people/containers. The integrated controls information will be managed in a secure