RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of transposable elements in human brain evolution' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The human brain is the largest and most complex of all primates possessing unique cognitive functions but also suffering from neurological disorders. However, little is known about primate brain development and the modifications enabling brain enlargement as primate tissues are not available at early developmental time points. Only few changes occurred in protein-coding genes; thus, significant differences must be present in gene regulatory processes. It is essential to analyse primate models to identify and understand molecular features unique to the human brain.Transposable elements (TEs) are mobile pieces of DNA comprising 50% of primate genomes. They can contribute to genome evolution as they carry regulatory sequences and have been found to serve for example, as enhancers and alternative promoters. Moreover, TEs are insertional mutagens leading to genetic disease. They are silenced by repressive marks including DNA methylation. Interestingly, methylation can sometimes spread and impact adjacent regions making TEs noteworthy candidates for methylome evolution. Due to their challenging analysis and lack of primate material, the role of TEs in primate brain development and human brain evolution has not been investigated thoroughly.Here, I propose that human-specific TE insertions have the capacity to act as repressors and silence genes in brain development. Exploiting human and non-human primate cerebral organoids as a model for brain development, and Oxford Nanopore Technologies long-read DNA sequencing to detect DNA methylation, I will analyse locus-specific TE methylation spread to nearby genes. Using differential expression analysis and CRISPR-Cas9 genome editing, I will assess the effect of putative repressor TEs on gene expression revealing if the repression of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Preventing unnecessary biopsies in the diagnosis pathway of cervical cancer.'.

assistant: **Innovation**

The goal of the DIADEPH project is to develop a “Business Proposition Package” that could enable our group to eventually bring a new non-invasive gynaecological device to market. The device holds promise to reduce the number of biopsies that are currently carried out to rule out cervical cancer, thus mitigating the pain, anxiety, and financial costs that the shortcomings of the diagnosis pathway brings today on patients, their families, and our society.  Every year, more than half-a-million women are diagnosed with cervical cancer: for half of them, the diagnosis is a death sentence. This terrible disease often affects young lives: in Europe, it represents the 2nd most common form of cancer among women aged 15-44.  The diagnostic evaluation starts if, during a periodical screening, the patient is found positive to high-risk Human Papilloma Virus. The patient is then primarily referred to colposcopy to look for possible signs of cervical intraepithelial neoplasia (CIN). Unfortunately, this exam leaves much to be desired: even for high grade leasions (CIN3), colposcopy gives a false negative in almost one case in three.To address the shortcomings of colposcopy, we propose a new transvaginal probe that obtains two independent neoplasia indicators: (1) a high-resolution 3D subsurface image, and (2) a quantitative assessment of its mechanical properties. The data are collected during a procedure that does not generate discomfort and is expected to provide a better diagnosis in a few minutes. We already developed a prototype for dermatological analysis, and tested it on volunteers; with this grant, we will convert the current form factor to enable transvaginal measurements. Supported by a team of physicists, engineers, medical doctors, and business developers, we will analyze
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable, Engaging and CREative Tourism as a driver for a better future in rural and remote areas' (SECreTour).

assistant: **Concept**

Tourism is more than travelling and consuming and it has a great potential for sustainable development when it focuses on culture, nature, knowledge, and experiences. Creative Cultural Tourism can be used as a driver for innovation and cooperation and, to counteract its negative impacts, SECreTour will primarily focus on the local communities’ needs, perceptions and expectations. Tourism will be conceived as a tool to complement and diversify the income of the territories and communities, but also as a way of giving visibility and recognition to rural areas and their inhabitants, also promoting the installation and generation of services other than cultural.By developing a Fair, Creative and Sustainable Tourism (FaCS-Tourism) approach together with Heritage Communities (HC), the SECreTour consortium will assess the sensitivities and affordances of different local realities, needs and types of cultural heritage, visualizing and avoiding touristification and promoting alternative business models. FaCS-Tourism and HC will therefore enable governance and citizen engagement not only for touristic-economic planning, but also for community building and cultural heritage management and protection.Through a series of pilot cases, the project will demonstrate how cultural heritage can be used as a real driver for sustainable and fair development, promoting at the same time its conservation. Pilots have been carefully chosen to represent a full range of European territories, communities and heritage, including not only rural and agrarian landscapes, but also memory places of local identities, minorities, conflictive dark heritage. Pilots will be a focus for every part of the research as they will enable to test general ideas and observations in local detail and in specific governa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biotechnical methods in the maintenance of genetic diversity of lipizzan horse breed' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Foreseen ResultsA book will be published, summarizing the results of the scientific cooperation. The book will contain the history of the breed, the morphologic parameters (breed standards), the results of immunogenetic and molecular genetic investigations and a computerized stud book system, which will also be established during the study. The results of this interdisciplinary work will be useful in practice both, for avoiding the possible damage of close inbreeding, and in the preservation of the endangered Lipizzan breed. The LIF, partner No 4, undertakes the task of dissemination of the results among the Lipizzan breeders throughout European and the world.The goal of this project is to present a scientifically based description of the phenotypic and genotypic structure of Lipizzan horses and to make recommendations on the use of the results in practice.The Lipizzan breed can be regarded as a Paneuropean horse because the traditional studs, though small, are found in many EU and CCE countries and now it is bred in 17 European states. The number of pure bred mares in original studs is small and so the preservation policy of the breed is also important. These elegant Baroque type horses are part of European cultural heritage and are suitable for riding, driving and light draught work besides their use in the Spanish Riding School.The scientific goal of the partnership is to detect immunogenetic, polymorphic parameters, DNA markers and to study them in relationship with morphologic and performance parameters of horses. Health status will be also included. Pedigree analysis is an important part of the project, because the problems of inbreeding,the characteristics of traditional lines and families are also a substantial part of the study. Thus, an estimation of expressiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'TCF4 target gene program and mesenchymal niche in intestinal crypts and colon cancer' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The canonical Wnt pathway plays an essential role in the establishment of colon cancer. The mutations implicated in tumour transformation lead to stabilization of beta-catenin, inducing constitutive activity of the pathway. TCF4 is a transcription factor activated downstream of Wnt.   Beta-catenin/TCF4 has been shown by Clevers and colleagues to activate a genetic program in colorectal cancer (CRC) cell-lines, which inhibits differentiation and imposes a crypt progenitor phenotype to these cells. This genetic program is also active in the proliferative compartment of the colon crypts, controlling the switch between proliferation vs. differentiation.   The Clevers lab has also shown that Tcf4 -/- mice fail to maintain a proliferating stem cell compartment in the crypts. A pilot-DNA array analysis of late embryonic intestine has shown that mesenchymal cells surrounding the crypts of Tcf4 -/- mice have decreased expression in some genes. Thus, the absence of crypt formation in Tcf4 -/- mice may in turn induce defects in the surrounding mesenchymal cells. The canonical Wnt pathway likely plays a crucial initiating role in epithelial-mesenchymal interactions to shape the crypt as well as the surrounding mesenchymal cells to create a crypt stem cell niche. Since adenomas arise at the crypt-villus border, similar interactions may be implicated in adenoma formation.   In this proposal we aim to:  1) Identify TCF4 target genes expressed in the crypt epithelial cells affecting mesenchymal cells;  2) Functionally define the signalling molecules and the mesenchymal genes that build the crypt niche;  3) Investigate the relevance of such niches in adenoma formation.   DNA array analyses from CRC cell-lines and in vivo approaches will permit a selection of candidate genes. By using tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mnk control of cytokine expression in t-cell activation' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Identification of the molecular mechanisms and signalling events underlying the control of cytokine expression in T-cells, highlighting the pro-inflammatory cytokine TNFalpha. Characterisation of the roles of the protein kinesis MNK1 and MNK2 and RNA-binding proteins in regulating the translation of cytokine minas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Roadmap for Industrial Symbiosis Standardisation for Efficient Resource Sharing' (RISERS).

assistant: **Innovation**

Industrial symbiosis (IS) is a key solution to address the challenges of conserving natural resources, yet the lack of standards and the difficulty in IS standardisation due to its cross-sectoral nature and additional bottlenecks impede the uptake of IS solutions. RISERS aims to address such bottlenecks through the development of a roadmap towards IS standardisation, promoting resource sharing and the integration of new R&I results to support IS. To this aim, we will operate in several dimensions: (1) Identification of gaps and opportunities in existing sectoral practices and standards for the uptake of priority IS synergies; (2) promote the uptake and contribution of R&I results to IS standardisation through identifying demand-led R&I priorities, as well as through identifying barriers and enablers to market entry for innovative IS solutions; (3) engaging the policy community in IS standardisation through suggesting new or adjusting existing policy Frameworks and initiatives. These activities will be conducted through constant engagement of experts and stakeholders from the industry, standardization bodies, academia, policy, funding bodies and additional relevant stakeholders and continuous dissemination op results and knowledge for their uptake, fostering community building, knowledge exchange and cross-sectoral collaboration. Based on the knowledge developed and gained in all these activities, RISERS will develop a roadmap for developing new or adjusting existing directions IS standardisation to promote circularity of resources. In the long run, thorough facilitating IS standardization RISERS will contribute to, among others, effective use of resources and cross-sectoral interoperability in resource sharing, easier market entry for innovative IS enabling technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'KEEN Quality Keeper - A Competence and Quality Assurance System representing a totally new standard for the health care sector' to be submitted under Horizon 2020.

assistant: **Abstract**

Across the EU we are aiming for more safe and secure care facilities, but with fewer resources than before. At the same time, the public scrutiny and the tolerance for error among key incident stakeholders is decreasing. Current approaches cost valuable time, requiring complex planning exercises with inherent risk of unnecessary errors. Especially when facing current restraints of available staff, minimizing read tape with a limited budget in mind. A novel approach is required to reduce risks of incidents in a cost-effective way, improve care staff training and ensuring full documentation in e.g. insurance cases to ensure full reparations, through full, cost-effective compliance.  This is reinforced by increasing restraint on the nurses’ time, and urges additional training, to ensure a high quality of care; at the same time remaining fully compliant with safety and security regulation, e.g. being perfectly prepared for first aid, fire and fall incidents 24/7, ensuring recent training for all teams. KEEN Quality Keeper (KEEN) a disruptive Competence and Quality Assurance System reduces the risks of costly accidents and comply with legislation by continuously training nursing homes staff to ensure proper certification. With the SME instrument support we will validate KEEN internationally with nursing homes, but also service flats, home care services and hospitals, scale-up our cloud platform and implement the functional improvements, preparing KEEN for full speed market launch by 2019.Now is the perfect time for KEEN to enter the market. Combining our fast market expansion strategy with the need growth will allow us to reach 50M EUR 5 years after completing the project (2024).KEEN has been developed to the stage where it is ready for testing under real world conditions. A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Comprehensive study of the organs and tissues through which insulin-like signalling affects lifespan in Drosophila'.

assistant: **Objectives**

An evolutionarily conserved neuroendocrine signalling pathway, the insulin/insulin-like growth factor signalling (IIS) pathway, controls ageing in a number of distantly related organisms. This control appears to result from a complex interaction of different tissues acting as signal emitters and receptors. Using systematic approaches, this project aims to identify the organs and tissues through which IIS affects ageing in Drosophila melanogaster.A combination of biochemical, histological and genetic techniques will be applied to whole adult flies in order to identify the organs/tissues capable of binding the relevant Drosophila Insulin-Like Peptides as well as those able to mount a transcriptional response to these peptides. Subsequently, the role of these signalling centres in ageing will be directly determined. In parallel a complex genetic screen is proposed to allow unbiased identification of the relevant organs and tissues based on a functional, phenotypic test. The study will yield a comprehensive understanding of the tissues involved in lifespan regulation by IIS and a solid framework for further investigation of the molecular basis of ageing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Air Quality at the Urban-Rural Interface'.

assistant: **Innovation**

AQURIPoor air quality (AQ) is of major concern to policy makers and public alike, but is proving impervious to current mitigation efforts. In many areas, the dominant source of air pollution is the formation of secondary pollutants (ozone and aerosol) from the atmospheric reactions of volatile organic compounds, over 90% of which are biogenic in origin. Yet few atmospheric chemistry models currently used to simulate AQ include dynamic representations of interactions between the terrestrial biosphere and the atmosphere. Furthermore, elevated ozone concentrations damage vegetation, reducing productivity and altering emissions of biogenic ozone precursors. This project will address these critical omissions, developing a ground-breaking model of the exchange of trace gases and particles between forest canopies and the atmosphere that can be used to improve the performance of AQ models. The model will be applied to determine the effects of peri-urban forests on urban AQ and vice versa.Trans-disciplinary research in plant ecophysiology and atmospheric science at key experimental sites based in a peri-urban forest in central Italy and in a boreal forest in Finland will fulfill the specific scientific objectives:- Acquire and apply advanced micrometeorological techniques to improve understanding of forest-atmosphere exchange of trace gases and particles;- Develop a state-of-the-science model of the processes involved in these interactions, improving current parameterisations of deposition and uptake of air pollutants through plant stomata and introducing the effects of ozone damage to vegetation;- Quantify the effects of future change on urban and peri-urban AQ, and the resulting impact on the productivity of peri-urban forests; - Derive parameterisations of the key processes s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Toolbox for Offshore Wind Farm Cluster Design' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Today, an offshore wind farm is merely a collection of wind turbines where the components of an offshore wind farm cluster are optimized but not the overall cluster. In the future, the best-performing wind farms will be designed with an integrated approach. For this purpose, design tools for offshore wind farm clusters must then yield for the overall optimum. This means they must integrate the cluster and grid connection design with new intelligent mechanisms for wind turbine, farm and cluster control already in the design phase.The objective of the project is to develop toolbox for such an integrated offshore wind farm clusters design. In line with the call this is achieved by combination of the following different design optimisation tools elements as advanced wake models, turbine load models, grid interconnection models and by incorporating the operation of the offshore clusters as a virtual offshore power plant.  The consortium will depart from existing state of the art models that are further developed within the project.In parallel extensive measurements and data collection is carried out in order to validate the models, to calibrate and further improve them. Furthermore the developed control mechanisms for virtual offshore power plant operation will be tested in existing wind farms to verify that indeed an increase of the overall energy yield, a reduction of load on the single turbines and a flexible operation of the wind farm clusters is achieved.