RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High throughput epitaxial reactor development for solar cell manufacturing from mg-silicon (EPIMETSI)' (EPIMETSI).

assistant: **Innovation**

Objectives and problems to be solved:The objective of this proposal is to fabricate silicon thin film solar cells on metallurgical silicon substrates with a high throughput epitaxial reactor of novel design. This reactor will be able to be fed with electronic grade source gases or with gases obtained in site from metallurgical silicon (MG Si). In this way, MG Si will be treated along two circuits, one producing medium purified substrates and other producing highly purified epitaxies where the cell is fabricated, to directly obtain solar cells starting from it. Even if electronic grade epitaxy source gases were used, important cost reduction of the cells is expected in the medium term when sufficient learning is achieved. But more important in the shorter term is the security of the supply of wafers as starting material for solar cells thus facing the problem of silicon feedstock shortage in the near future.Description of work:The achievement of this R&D goal will be pursued by addressing the following lines:1. Upgrading metallurgical silicon to a level suitable for epic - cells substrates;2. Design and prototype demonstration of a high throughput epitaxial reactor;3. Design and prototype demonstration of re-circulation and synthesis of pure gases for epitaxy growth and 4. Development of appropriate processing for epic - cells. Industrial perspective will be sought for by 5. Conducting manufacturability studies in a factory environment and 6. Cost and market analysis. The consortium includes a leading photovoltaic manufacturing company (ISOFOTON) that will act as coordinator and will ensure the industrial compatibility of the developed techniques.A metallurgical silicon manufacturer (ELKEM) and a producer of cast silicon and casting equipment (Crystalox) will work in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A patient-centered early risk prediction, prevention, and intervention platform to support the continuum of care in coronary artery disease (CAD) using eHealth and artificial intelligence'.

assistant: **Concept**

Coronary artery disease (CAD) remains the leading cause of disease burden globally. CAD develops slowly, usually over decades, and depends on multiple (often modifiable) risk factors and their interactions. Self-management and patient activation are of rising importance as current restrictions in healthcare budgets impose great difficulties to enable the provision of qualitative secondary prevention to all cardiac patients in an era facing a huge cardiovascular disease epidemic.The main hypothesis in the patient-centered TIMELY pathway, is that a modular, collaborative eHealth platform, supported by Artificial Intelligence (AI) for the continuous and in-time prediction of cardiac risks and complications and the induction of targeted behavioural change interventions, can be effective and cost-efficient for the secondary prevention of CAD by limiting the physiological and psychological effects of the disease and improving risk factor and symptom management. Improvements in patients’ self-care and empowerment and clinicians’ efficiency are also expected.Along the continuum of the disease, prediction of the individual risk for disease progression, including physical impairment and severe events, is mandatory for timely intervention. TIMELY is a platform that provides AI-powered apps and dashboards and decision support tools assisting patients and clinicians to personalize healthcare based on risk evaluation, outcome prediction and tailored interventions. The platform will be developed based on a functional platform for Interoperability with electronic health records and security mechanisms, to ensure information completeness and continuity and to simplify data sharing. AI in TIMELY, built with big retrospective datasets of >23.000 CAD patients, will constantly monitor and e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Cellular protein damage control: interactomic analyses of MOAG-4 in C. elegans'.

assistant: **Concept**

Several age-related neurodegenerative disorders, such as Alzheimer’s, Parkinson’s and Huntington’s diseases, are characterized by the formation of pathogenic proteins aggregates in the brain. Although some regulators have been identified, how aggregates form during aging is poorly understood.Recently, a modifier of aggregation, MOAG-4, was identified as a positive regulator of aggregation in C. elegans models for neurodegenerative diseases. The role of MOAG-4 is evolutionarily conserved in the human orthologs SERF1A and SERF2. MOAG-4/SERF appears to regulate age-related proteotoxicity through a previously unexplored pathway. Therefore, how this regulator works and in which pathway it acts needs to be established. In this proposal I focus on identifying proteins that physically interact and cooperate with MOAG-4 to drive protein aggregation.To this end, I will express in worms that lack MOAG-4 a tagged version of MOAG-4 to co-purify MOAG-4 interacting proteins. I will use different proteomic approaches to identify putative substrates and proteins that may form functional complexes with MOAG-4. These interactions will be confirmed in vitro and in vivo. In addition, I will study the proteotoxicity phenotype in mutant worms that are impaired in the expression of these proteins. I will also analyze the protein aggregation process by monitoring aggregate formation in a test tube with purified proteins.The results of this project will reveal the mechanism by which MOAG-4 acts, and this will contribute to our understanding of how cells cope with toxic, aggregation-prone proteins during aging. Furthermore, new options will be opened for the development of therapeutic strategies to treat human neurodegenerative diseases.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Uncovering the link between bacterial growth and secondary metabolite dynamics in soil biocrusts', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Bacterial secondary metabolites are highly valuable to humanity as antimicrobials. However, the antimicrobial discovery rate has been lagging behind rapid resistance development. Our lack of knowledge about when and why different taxa produce secondary metabolites is a major source of difficulty in the discovery process. Studies on Actinomycetes in batch culture have shown that secondary metabolites tend to be produced in stationary phase, but evidence suggests that production dynamics are different in other phyla as well as in situ. The goal of this project is to understand how in situ and in vitro SM production dynamics relate to growth rate and transcriptomic changes in soil bacteria. To achieve this, I will conduct a time-series rewetting experiment on a Negev desert biocrust as a model system of soil with reduced diversity. I will apply quantitative stable isotope probing metagenomics and metatranscriptomics to each timepoint to obtain a specific growth rate and expression profile for each metagenome-assembled genome. I will supplement the in situ data with in vitro expression studies in isolates. Together, this will allow me to assess how growth rate & phase, expression of other pathways, and the soil environment impact secondary metabolite biosynthetic gene cluster expression. The results of this project will give unprecedented insights into the dynamics of secondary metabolite production, challenge long-held assumptions, and ultimately lead to improved discovery pipelines.


**Keywords:** Bacterial secondary metabolites, stable isotope probing, metagenomics, metatranscriptomics, biocrusts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'OFFICE BUILDING FOR RIJKSWATERSTAAT WITH HEAT PUMP AND NATURAL VENTING SYSTEM IN TERNEUZEN - NL' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Optimisation in functional design, the use of sustainable materials, maximisation of individual control and maximum use of natural forces, resulting in a new office building with a gross total floor area of 1750 m² for the housing of 50 employees, which combines:- low energy consumption (heating and cooling by heat pump, PV cells, solar collector for DHW, low energy content of used materials, compact building envelope, high insulation level);- low water consumption (use of greywater circuit, purifying of waste water);- sustainable material use (low environmental harm, low emissions, use of recycled materials);- good indoor environment (thermal comfort, low temperature, radiation heat, natural forced ventilation system, humidity/dust control by plants, individual controls, use of daylighting);- minimal affection of outdoor environment (green roof, minimal paved area, diversity in plantation);- preference will be given to environmentally friendly materials and use of an energy environmental contract for the evaluation of the results.The expectations of these objectives are:- 16700 m³ saving of natural gas/year;- 43800 kWh saving of electricity/year;- high indoor air quality and thermal comfort;- minimum affection of the environment;- 15% cost reduction at long term.The estimated pay-back is 11.9 years based on total investment of 3.112.880 ECUThe architectural design is adjusted and optimised on behalf of the aims of the project. Definite energy and daylight calculations are available. Test are made of the comfort of the natural air supply in the offices. In some cases comfort problems can be expected. For this reason extra provision in the sealing will be added. Calculation of overheating are available. In some situations overheating is a problem. These results will be u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Polarized electron transport in inhomogeneous magnetic microstructures and localization in the integer quantum hall regime' in the context of a Fourth Framework call.

assistant: **Objectives**

In the first part of this project we will study the spin-dependent transport of electrons across a ferromagnet-semiconductor (FS) interface. The presence of a potential barrier (Schottky barrier) at the FS interface will also be addressed. Next, we plan to thoroughly study the injection of spin-polarized electrons into a two dimensional electron gas at the semiconducting side of the interface by considering in detail many-body effects like exchange and correlation. By allowing for spin channel mixing at finite temperatures via electron-magnon scattering our calculations will provide a basis for understanding the room temperature giant magnetoresistance effect.  In the second part we will focus on the localization transition in the Integer Quantum Hall effect. In our calculation both types of disorder (on scalar and vector potential) will be included on equal footing by adopting a lattice model of spin- less fermions the low energy physics of which is described by a free particle Dirac equation. Within our model the edge state problem, and the tunneling among transmission edge channels, will be addressed in detail.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of dissolved organic nitrogen (DON) on the development and extend of eutrophication-driven hypoxia and responses to global warming' (DON).

assistant: **Concept**

Coastal hypoxia is a mounting problem worldwide that has been recognised as a major threat to marine coastal biota. The decline in dissolved oxygen can affect ecosystems structure and functioning. Managerial efforts to prevent hypoxia and recover ecosystems that have already been affected by hypoxia are largely based on nutrient reduction plans. Most nutrient reduction plans are focused on the reduction of the inorganic fraction of the nutrient loadings, particularly in reductions of nitrate and phosphate inputs. However, the concentration of dissolved organic nitrogen (DON) frequently exceeds that of dissolved inorganic nitrogen (DIN) in both marine and freshwaters. Recent studies indicate that many components of the DON pool can play an active role in supplying, directly or indirectly, nitrogen nutrition to phytoplankton and bacteria and may affect community metabolic rates and species composition of the ambient microbial assemblage. Elucidate the role of DON in the development and extend of eutrophication-driven hypoxia is essential to set successful management strategies in order to reduce hypoxia development and recover ecosystems experiencing hypoxia at present, to better protect marine biodiversity. The main goal of this project is to evaluate the role of DON in planktonic and bacterial community metabolic rates, and on oxygen dynamics in the Baltic Sea, the largest coastal area suffering from eutrophication-driven hypoxia. The project also aims to evaluate the effects of global warming in the interaction between DON inputs, metabolic rates and oxygen dynamics. Predictions on effects of global warming and eutrophication in dissolved oxygen dynamics in near and far future are needed to elucidate the consequences of the lack of oxygen on biodiversity and ecosystems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chromatin diseases: from basic mechanisms to therapy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies; so far for the vast majority of them no treatment is as yet available. Molecular studies on these pathologies thus have a twofold value: to shed light on the intricate interplays between different levels of control of gene expression acting in the mammalian nucleus and to pave the way toward new and more effective strategies to approach the treatment of this increasing class of diseases. Our students will take advantage of the integrated approach on multilayered gene regulation, the multidisciplinary nature and the cutting-edge methodologies, which are an integral part of this proposal. We thus expect to provide a framework for the very high-level training of young researchers, receiving a strong backgrounds in molecular, cellular and developmental biology, genomics, bioinformatics, chromatin biology and epigenetics. Furthermore, they will develop expertise in many cutting edge methodologies and tools, such as imaging, high throughput gene technologies, ChIP. As a result, the ESRs will be highly competitive in performing independent research in various areas of biology and will represent a new breed of scientists trained in contemporary post-genomic biology using advanced technological tools to tackle human disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A New Therapeutic Option to Protect Central Nervous System against Acute Ischemic Stroke' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Each year, about 16 million strokes occur in the world causing millions of deaths and one third of patients experiencing permanent disability. The main treatment of stroke is thrombolytic agent recombinant tissue plasminogen activator (rtPA). Not all the patient can qualify for this treatment and it can be administered only in a limited time window. No existing drug is approved to protect against ongoing neuronal damage after the acute event. In this framework, our company, ORPHIT, a seed-stage biotech company, intends to be a pioneer by bringing clinical proof of concept of our peptide SYN1002 as suitable neuroprotective anti-inflammatory agent to treat stoke in acute phase that could be administered at multiple doses as complement to current thrombolytic treatments and also in patients who do not qualify for treatment with rtPA. This peptide is our lead product and has been initially developed as a potent anti-inflammatory substance in auto-immune pathologies with a clinical phase 1 study successfully documenting the safety and tolerability. Its properties make it a perfect match with current needs on Stroke treatment. Therefore, our solution is of interest for the pharmaceutical industry and health institutes who are currently in the search of a treatment that would be efficient and safe enough to be applicable to a larger part of the persons suffering from Stroke. The acute ischemic stroke (AIS) therapeutic market generated 400M€ in 2012 across the six major markets and is expected to reach 1.1 billion € by the end of 2017. SYN1002 sales at peak (2026) are expected to achieve 50% of market share, and a licensing deal at end of phase IIa would come out with a net present value of 265M€ for our company. In order to achieve this goal ORPHIT will realize a feasibility s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transforming cryogenic optics for cosmic microwave background experiments' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Future experiments mapping the cosmic microwave background (CMB) are designed to revolutionize our understanding of the infant universe, the standard model of particle physics, structure formation, and the nature of dark matter. A key effort involves constraining or detecting the energy scale of cosmic inflation.  A detection would mark a watershed moment in cosmology and high-energy physics, but in order to push constraints significantly past current limits, we need a dramatic change in instrument characterization capabilities — the primary focus of CMBeam.To address this challenge, we propose to construct a novel cryogenic holography facility for the purposes of testing optical systems of current and future experiments observing at microwave frequencies (40–400 GHz). We will use this facility to develop never-before-seen optical measurements that are critical for the success of next-generation experiments studying the CMB. As part of this program, we will perform warm and cryogenic (4-Kelvin) holography measurements of a complete reimaging optics tube for the Simons Observatory Large Aperture Telescope, the flagship CMB experiment of this decade. In a complementary effort, we will lead an ambitious analysis and calibration program for the Simons Observatory, which will deploy 60,000 cryogenically cooled detectors — three times the number of currently fielded detectors globally — in a site located 5,200 m above sea level in the Atacama Desert, Chile. Finally, we will develop algorithms that enable the design of novel freeform (asymmetric) optical systems that can greatly extend the scientific reach of future large-aperture telescopes such as upgraded version of the Simons Observatory and the CMB-S4 experiment.


**Keywords:** Cosmic microwave background, cosmology, opt