RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '(Bio)Materials Molecular Simulations' (Bio) under Sixth Framework.

assistant: **Objectives**

Modern material science aims at understanding the properties of (bio)materials at the molecular level. In this development, molecular simulation will play an important role in both the interpretation of the experimental data as well as to guide the experim ental efforts. Key aspects in the present proposal is that we plan to achieve this goal by a hierarchical approach, which relies on an intelligent and controlled way of combining advanced simulation techniques to bridge the time and length scales between t he molecular behaviour and the macroscopic properties. To demonstrate the interdisciplinary character of this approach we plan to apply this approach to two different applications related to molecular system biology and molecular materials science. Within the framework of system biology we aim to obtain fundamental insight in the collective behaviour of peptides embedded in a biological membrane and in material science we will investigate the effect of confinement on diffusion and catalytic properties. The field of molecular simulations is one of the scientific areas in which Europe has a leading position. European research teams are internationally recognized for the development and application of novel algorithms. One of the factors contributing to this Eu ropean success is the unique position of CECAM (European Centre of Atomic and Molecular Computations). CECAM is a top-level institute based in Lyon that is supported by 14 European organizations and is aimed at networking activities (workshops and tutorial s). The present proposal takes advantage of this unique position and the support will be used to create a European Research Centre of Excellence that will be located at CECAM in collaboration with the universities in the Lyon region. The present proposal a llo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ecO-evolUTionary dynamics in COMmunitiEs' (OUTCOME).

assistant: **Concept**

Host-parasite communities compose networks of interacting individuals of different species. These communities are constantly coevolving, i.e. reciprocal selective pressures. Coevolution produces ecological changes, such as dynamics in demographies or in the distribution of interactions. Such ecological changes may feedback to drive further evolution in the communities. However, coevolutionary research usually focuses on isolated host-parasite pairs, assuming that the ecological effects can be ignored. Similarly, ecological studies argue that coevolution is not fast enough to affect ecological processes. Hence, the reciprocal effect, or eco-evolutionary feedback, is generally ignored by both evolutionary and ecological studies when evaluating host-parasite interactions. These assumptions possibly lead us to inaccurate understanding of the processes driving host-parasite communities and ecosystem dynamics in general. I aim to infer and predict coevolutionary outcomes in communities of several host and parasite species from host-parasite interaction networks and demographic histories. I will develop a unique combination of coevolutionary footprints in whole-genome sequences with dynamic network analysis (i.e. the network changes the distribution of interactions according to selected genotypes over time). I will use theoretical models and simulated data to link population genetics with interaction establishment and specificity at the ecological community level. Using the theoretical models, I will finally build statistical inference tools to infer and predict changes in real-world ecosystems based on empirical genome and network data. OUTCOME brings together studies on genomic coevolution (Prof Tellier, TUM), eco-evolutionary dynamics in empirical communities (Dr Möst, UIBK
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Antiferromagnetic Spin Transport With Relativistic Waves'.

assistant: **Concept**

While photonics has already enabled nearly lossless Tb/s transfer of data using light waves, computing at THz clock rates is the next monumental challenge. Magnonics, which employs spin waves (SWs) instead of light waves, is widely seen as one of the most appealing solutions to this problem, but so far only operates at GHz rate. Interference of SWs enables nearly lossless protocols for logic operations. The large natural nonlinearity of SWs can be used to control their mutual interaction, propagation and manipulation of magnetic bits - altogether facilitating the concepts of transistor and logic-in-memory devices. Since the wavelength of THz SWs is orders of magnitude shorter than that of THz photons, THz SWs offer enviable scalability down to the nanoscale. How to push magnonics into the THz domain and enter the nonlinear regime? How large are the THz nonlinearities? Answering these questions will open up new avenues to scalable technologies for THz and nearly lossless computing.With ASTRAL I want to enter the nonlinear regime of THz magnonics by generating ultrashort large amplitude SW pulses that, similar to femtosecond laser pulses in optics, can zip undisturbed over long distances unlocking the nonlinear regime of interaction between the pulses, other SWs and even macroscopic spin textures. I propose to focus on antiferromagnets, where SW frequencies can easily reach the THz landmark and, similar to light waves in vacuum, follow a linear, so-called relativistic, dispersion relation. Owing to this, a broadband wavepacket of coherent SWs can be compressed to an ultrashort SW pulse - a bunch of few-cycle large-amplitude spin oscillations.To achieve this, ASTRAL will exploit the exclusive ability of light to initiate ultrafast spin dynamics and will attempt to intercon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neurobiological Mechanisms of Memory Loss in Alzheimer's Disease' (MEMOLOAD).

assistant: **Concept**

The MEMOLOAD project will focus on the molecular and biological mechanisms underlying memory loss that occurs in Alzheimer’s disease, the leading cause of dementia and an enormous medical, social and economic challenge to Europe.    Several lines of evidence point to accumulation of beta-amyloid peptide (Aß) in the brain as the key pathologic event in the disease.  There is growing evidence that Aß causes memory loss by directly or directly interacting with the known key signalling pathways involved in memory consolidation. However, at present the data is fragmentary and consists mainly of single observations in particular models (cell culture, brain slice, in vivo). In most cases, we still lack the evidence that a clear molecular level interaction translates into memory impairment in vivo.    The objective of this proposal is to elucidate the molecular level mechanisms by which accumulation of Aß in the brain results in impaired synaptic plasticity and memory loss. The MEMOLOAD consortium consists of a well-balanced mixture of the seven best available European research groups in terms of research experience on both the mechanisms of memory consolidation and the pathophysiology of Alzheimer’s disease. The current research topic is thus the primary research interest of all partners.   MEMOLOAD will significantly contribute to a better understanding of brain memory mechanisms at the behavioural, network, synaptic and molecular levels and of dysfunction at all these levels in Alzheimer’s disease (AD). The knowledge acquired during the course of MEMOLOAD will translate into new validated in vitro and in vivo models for the memory impairing effect of Aß and will feed into industrial development leading to new therapies. The output of MEMOLOAD will include both identification
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ACcess To Micro-Optics Expertise, Services and Technologies' under Seventh Framework.

assistant: **Concept**

Micro-optics holds tremendous potential for SMEs and large companies to develop competitive products and to boost product innovation. Micro-optics however continuously requires advanced knowledge as well as a complex technology supply chain, which are very often not affordable. This project targets to pro-actively provide companies with timely, cost-effective, investment-free Access to a unique one-stop-shop" European Centre To Micro-Optics Expertise, Services and Technologies "ACTMOST". The access of predominantly SMEs to leading edge technology and knowledge provided by the ACTMOST partners will be realized by them through focused collaborations in so called user projects and through hands-on training of industry staff in highly advanced laboratories of the ACTMOST research institutions. ACTMOST also targets to develop a business model which would enable continuation of SME and company support without public funding. As such ACTMOST intends to be a major driving force to sustainably support European industry in keeping a leading position in micro-optic and micro-photonic enhanced products, thus strengthening the competitiveness of Europe and creating new jobs.<br/>"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Disk, Planetesimals and Planets' in the context of a Fifth Framework call.

assistant: **Objectives**

The EXoPlanetary Observational Research Team (EXPORT) was awarded 100% of the international observing time of the Canarian observatories in 1998 for their Planetary Systems: Formation and Properties" project. The excellent instrumentation and observing conditions throughout the observing campaigns enabled them to amass a quite unique database with regard to the formation and evolution of exoplanetary systems, the study of the giant exoplanets of nearby stars and the search for new exoplanets. The results obtained will be presented to the international astronomical community in a conference entitled "Disks, Planetesimals and Planets" to be celebrated at Puerto de la Cruz (Tenerife) from 24 to 28 January 2000.This conference will also serve to contrast our findings with those made in other wavelength regions by other groups at other ground-based and space-borne facilities and will provide a synthesis of present-day knowledge in the field of exoplanetary formation and evolution, which is now such a timely scientific topic and one which is much in the public eye.The event is being organized by the EXPORT group in collaboration with the Instituto de Astrofísica de Canarias. The Local Organizing Committee comprises the following members: F. Garzón (Chairman), H. Deeg, B. Montesinos, M. Murphy (Secretary) and D. de Winter. The Scientific Organizing Committee consists of the following members: S.C. Eiroa (Chairman), D. de Winter (Vice-Chairman), R. Ferlet, M. Mayor, A. Natta, F. Paresce, A. Penny, A. Quirrenbach, H. Rauer, L. F. Rodríguez, E. van Dishoek and P. Wesselius.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00218-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Super-resolution microscopy for immune checkpoint inhibitors diagnostics' (NANODIAGNOSTIC).

assistant: **Innovation**

In the last decade, super-resolution microscopy techniques have emerged as powerful quantitative tools for biology. They have capabilities to visualize single molecules at the nanoscale opening the door to study biological processes at a level not accessible before. In the ERC StG NANOSTORM we showed the potential of these techniques providing new fundamental knowledge on the mechanism and design of new targeted therapies. However, some of the methods we developed have the potential to be translated into applied clinical diagnostic tools. In NANODIAGNOSTIC, we would offer a proof-of-concept of the application of super resolution microscopy and single-molecule imaging for cancer diagnostic, with a focus on patients stratification for immunotherapy. Novel advances in immunotherapies have brought the development of immune checkpoint inhibitors (ICI) that re-activate the immune system against the tumor. Despite the high success of these therapies there is one main challenge: they are only effective on a limited portion of patients and current diagnostic approaches are not capable of stratifying patient successfully. NANODIAGNOSTIC will translate advance optical methods from an academic setting to the clinic and holds a great potential to provide new diagnostic methods to improve the outcome of immunotherapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'UNconventional Integrated quantum nanophotonic sources From spontaneous sYmmetry breaking' (UNIFY).

assistant: **Concept**

The integration of reliable quantum sources on a photonic microchip is at heart of intense research in today quantum photonics. Our project is devoted to the realization of quantum correlations such as photon entanglement based on nonlinear interactions in semiconductor coupled nanocavities, ultimately with few photons. Unlike conventional semiconductor quantum sources that require deterministic coupling of emitters into small cavities and/or operation at ultralow temperatures, UNIFY will achieve unconventional sources with quantum correlations using Indium Phosphide-based bulk or quantum well photonic crystal cavities on Silicon, on-chip integrable and operating at room temperature in the telecommunication band. UNIFY relies on a recent theoretical prediction: photon entanglement from nonlinear optical transitions –i.e. bifurcations– in coupled cavity systems, such as spontaneous symmetry breaking (SSB). SSB-induced quantum correlations will be sought with either weak nonlinearities per photon and strong fields (continuous variable), or relatively large nonlinearities per photon in a few photon regime. UNIFY proposes to tackle them using a twofold strategy: passive (coherent excitation), and active (nanolaser) experimental configurations. For the latter, cavities with large spontaneous emission factor (β) will be realized to decrease the saturation photon number. The combination of nanocavities with tunable inter-cavity evanescent coupling, high-quality factors, ultra-small mode volumes, efficient input/output light coupling and high β-factors will ultimately lower the intracavity photon number below ~10. Such a platform is compatible with device integration on a photonic microchip, small footprint and scalability. We thus propose to unify an outstanding early career r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Bi-functional Cinchona Alkaloid derived Organocatalysts and their reactions'.

assistant: **Innovation**

Bifunctional catalysts operate in a similar fashion to enzymes by simultaneously activating both substrate and reagent and promoting a reaction where the stereochemical outcome is controlled.As both substrate and reagent are simultaneously activated, many new types of stereoselective reaction are waiting to be discovered.In this proposal, we introduce a new family of asymmetric bifunctional organocatalysts, which benefit from a strong Lewis basic site and a strong hydrogen donor group coupled to a rigid chiral scaffold originating from a cinchona alkaloid backbone.Such catalysts should be capable of not only promoting highly enantioselective reactions of acidic pro-nucleophiles (such as malonate esters) to reactive Michael acceptors (such as nitro olefins), but have the power to promote reactions between less reactive reagents (such as to alpha, beta-unsaturated ketones, esters, imides).If this is the case, then the implications of the chemistry for the synthesis of important enantioenriched building block s for the synthesis of natural products and drug compounds is phenomenal. The chemistry proposed is built on solid and exciting preliminary results.Unlike traditional metal ion catalysed reactions, the attraction of reactions catalysed by bifunctional org anocatalystsis in the technical simplicity of performing, monitoring, sampling and working-up the reactions to give the desired products.Glove box techniques are not required, variables associated with the metal ions (counterions, impurities, toxicity, disposal) are not introduced and moisture or oxygen sensitivity is not an issue.These benefits allow for rapid identification and optimization of the catalysts in the reactions and bode well for the use of the reactions in the pharmaceutical and related industries and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Flight reynolds number testing (1)' (FLIRET).

assistant: **Innovation**

Conventional wind tunnels face physical limits matching Reynolds and Mach number ranges. Cryogenic wind tunnels, operating at temperatures as low as -163°C and with variable pressures, allow a realistic simulation of flight Reynolds and Mach numbers hence allowing a highly accurate flow simulation at flight cruise conditions. For a highly accurate measurement a highly accurate model is mandatory. This also applies to the mounting devices needed for holding the model in the test section. However, since real aircraft have no mounting devices it is crucial to understand and to minimise the effect of these necessary devices. FLIRET's objective is to improve the accuracy of performance measurements at flight Reynolds number in cryogenic wind tunnels. The project focuses intentionally on model mounting techniques under cryogenic conditions. Model mounting devices have a significant influence on high Reynolds number performance measurements, which are currently compensated by empirical correction methods. It is assumed that an accurate prediction of the aerodynamic performance in cruise may allow for up to 10% improvement in present state-of-the-art aircraft design. FLIRET will investigate several model-mounting alternatives and compare the devices with existing state of the art stings. This includes · Designing and manufacturing of several model mounting devices (stings) · Appling and harmonising CFD and prediction tools including the necessary meshes · Analysing the test results of each FLIRET work package · Analysing the applied model quality, manufacturing and handling strategies · Deriving recommendations for the industrial testing in cryogenic tunnels A large proportion of FLIRET's budget is used for testing in the European Transonic Wind (ETW) tunnel, the only major cry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Elucidation of the different reaction mechanisms and pathways offered by the AOR' (EluMecAOR).

assistant: **Concept**

Green hydrogen produced from renewable electricity through water electrolysis can be converted via the energy-efficient Haber-Bosch process into green ammonia (NH3). Currently, large industrial efforts are under way to scale up production globally. With an expected surge in green NH3 supply, the question arises whether the stored energy can be released electrochemically in NH3 fuel cells. However, so far, high ammonia oxidation reaction (AOR) overpotentials and particularly a NO-poisoning mechanism have prevented application of low-temperature NH3 fuel cells. Therefore, this project focuses on the elucidation of key reaction mechanisms and pathways offered by the AOR (EluMecAOR). In particular, I hypothesize that metal oxide modifications on the Pt surface offer a way to reduce the AOR overpotential independently from the deactivation mechanism. To test this hypothesis, the catalyst surface composition will be modified using atomic layer deposition (ALD) of metal oxide clusters and characterized in detail, including fundamental electrochemical and operando microscopy and spectroscopy methods. This Marie Curie Fellowship combines my own expertise on fundamental Pt electrochemistry and the effects of metal oxide modifications with the world-leading expertise of the Interface Science Department at the Fritz-Haber Institute of the Max-Planck-Society on controlled nanoparticle synthesis and operando electrocatalyst research.


**Keywords:** Electrocatalysis, Ammonia electro-oxidation, Metal oxides, nanoparticle atomic layer deposition, Green Hydrogen, Operando Spectroscopy and Microscopy