RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High Dimensional Entangled Systems' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

HIDEAS aims at a breakthrough in the information capacity of Quantum Communication (QC), well beyond the standard single-mode approach, by exploiting the intrinsic multi-modal and multivariate character of the radiation field. Our long term vision is that of a broadband Quantum Communication, where all the physical properties of the photons are utilized to store information. Working at the quantum level requires  i) to produce quantum entanglement of light in high dimensional and multivariate spaces and  ii) to create multimode quantum interfaces between light and matter in order to store high-D quantum states of light in long-lived  matter degrees of freedom. Beneficial impacts will be also on Quantum Metrology.  As crucial steps towards these objectives we propose  five research lines:WP1 aims at bringing to the quantum realm the spectacular progress achieved by the introduction of frequency combs in the classical domain.WP2 aims at realizing sources of multimode spatially entangled light appropriate for paving the way to parallel quantum communication and  information processing.WP3 aims at realizing a very high-D entanglement between twin photons produced by parametric down- conversion (PDC). It focuses on the conjugate variables angle and optical angular momentum (OAM), providing a larger alphabet for QC and a more robust non-locality.WP4 explores  the non-factorable spatio-temporal X-structure of light entanglement in PDC, opening an avenue  that offers unique access to the full broad band of  PDC.WP5 exploits various forms of  multimode light-matter entanglement, to realize multi-modal light-atom quantum interfaces and a parallel quantum memory for light (quantum hologram), with resolution and memory capacity exceeding those of classical holograms.The consortium
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Large-scale synthesis of a new super oxidant material by recycling ferrous sulfate 'laferox'' under Fifth Framework.

assistant: **Concept**

EU's annual production of ferrous sulfate is about 5 million tons generated by the steel and Ti industries (SOLLAC, KEMIRA, etc.). Small part is used as antimoss and the rest is waste disposed. Alkalis ferrate 'AF' was successfully synthesized within contract No BRPR-CT97-0392 using FeSO4 and two patents are filed. AF has been tested on the laboratory scale and can replace current reagents in water treatment. AF are also efficient for effluents' decontamination, cyanide oxidation, organic materials' destruction, soil remediation, etc. The consortium proposes large-scale production of AF in sufficient amounts to test the mentioned applications on industrial scale by SLE and SMEs. It will design and construct a demonstration unit of 20 kg/h for AF production. The consortium will collect necessary data for the industrial production of these new multipurpose reagent around 2007 to satisfy the demand of various industrial sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel monitoring and process control system for efficient production of VFA and biogas in anaerobic digestion plant' under Seventh Framework.

assistant: **Concept**

The OPTI-VFA project focuses on improving the reliability, efficiency and profitability of AD processes by novel process monitoring and controlling tools. The main emphasis in the project will be in the development of production of VFA (Volatile Fatty Acids) as a route to bio-based materials, i.e. so-called VFA platform. In the VFA platform, the real time monitoring of VFA production will be of fundamental importance in the success of the further development of this process scheme. In the future scenarios, this platform is foreseen to play an important role in the material recycling in the bio-based economy.The number of operating agricultural anaerobic digestion (AD) plants has remained insupportable low, despite the numerous environmental advantages of AD process. Therefore, these tools are also applied in the conventional biogas production. The main challenges in the traditional biogas production are high investment costs of digesters, low profitability of biogas and energy production as well as the stability problems of operation especially in co-digestion plants. In this process scheme, the more efficient process control provides an approach to reduce the size and price of newly-built digesters, or to improve the performance and profitability of existing AD plants.The technological development in the process instrumentation in the OPTI-VFA project will focus on the MEMS-Fabry Perot based spectrometer and the science based calibration (SBC) method together with supervisory control and data acquisition systems for the effective control and optimization of both VFA and conventional biogas production. In all, an OPTI-VFA prototype with these new process instrumentation and automation features will be designed, fabricated, calibrated and tested in a modern AD pilot plan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flexible, scaLable and secUre decentralIzeD Operating System' (FLUIDOS), addressing dissemination and exploitation.

assistant: **Impact**

FluiDOS leverages the enormous, unused processing capacity at the edge, scattered across heterogeneous edge devices that struggle to integrate with each other and to coherently form a seamless computing continuum. By way of a disruptive, open-source paradigm that hinges upon secure protocols for advertisement and discovery, AI-powered resource orchestration and intent-based service integration, FluiDOS will create a fluid, dynamic, scalable and trustable computing continuum that spans across devices, unifies edge and cloud in an energy-aware fashion, and possibly extends beyond administrative boundaries. Notwithstanding its innovation signature, FluiDOS will build upon consolidated Operating Systems and orchestration solutions like Kubernetes, on top of which it will provide a new, enriched layer enacting resource sharing through advertisement/agreement procedures (in the horizontal dimension), and hierarchical aggregation of nodes, inspired by Inter-domain routing in the Internet (in the vertical dimension). Intent-based orchestration will leverage advanced AI Algorithms to optimize costs and energy usage in the continuum, promoting efficient usage of edge resources. A Zero-Trust paradigm will allow FluiDOS to securely control and access geographically diverse resources, while Trusted Platform Modules will provide strong isolation and guarantee a safe deployment of applications and services. FluiDOS will pursue the above goals through the creation of an open, collaborative ecosystem, focused on the development of a multi-stakeholder market of edge services and applications, promoting European digital autonomy. The involvement of stakeholders is planned from the outset of the project through pilots and demonstrator in the fields of intelligent energy, agriculture and lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High-power ultrasound for multiparameter single-cell mechano-phenotyping' (HUMPH), addressing dissemination and exploitation.

assistant: **Impact**

This project will push the limits of microscale ultrasound-based technology to detect and gain access to diagnostically interesting, rare cells in the blood based on a panel of acousto-mechanical properties. Microscale systems are powerful tools to examine and manipulate single cells. In addition, the high precision and potential for multi-stage serial processing offered by such microfluidic methods open up for isolation of rare cell populations, such as circulating tumor cells, and controlled size fractionation of sub-micron biological particles, such as platelets, bacteria, or extracellular vesicles.To achieve highly specific single-cell isolation of target cells, we will expose blood to acoustic radiation forces in a flow-through format enabling multiparameter characterization of thousands of cells. Based on this, new separation schemes will be developed that can isolate extremely rare circulating tumor cells from the blood of patients with prostate cancer. The project will render new fundamental knowledge regarding the mechanical properties of single cells and a framework to understand the response of cells to any aqueous medium, bounding geometry and sound field, and new tools to better understand the role of circulating tumor cells in metastasizing cancer as well as analyzing them for diagnosis and treatment guidance.


**Keywords:** PACS2010: 43.25.Nm: Acoustic streaming. 43.25.Qp: Radiation pressure. 43.40.Rj:Radiation from vibrating structures into fluid media. 47.35.Rs: Sound in fluids.43.35.Ud Thermoacoustics, high temperature acoustics, photoacoustic effect.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Biophysical Manipulation of Adult Stem Cell Epigenetics (BioMASCE) By Cell-Penetrating Nanoneedle Substrates'.

assistant: **Innovation**

Human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies. In part, their capacity for multi-lineage differentiation and subsequent therapeutic efficacy is controlled by the epigenetic status of the DNA. The Stevens Group at Imperial College London (ICL) has recently developed a novel material platform of porous silicon (pSi) nanoneedles (nNs) that penetrate the cell membrane, stimulating physical changes in the nucleus. Interestingly, nuclear mechanics and shape parameters have been shown to control epigenetic status in various cell types, but this remains under-investigated in hMSC. Therefore, in the present study, pSi nNs will be used to manipulate hMSC nuclear size and shape, as well as the resulting epigenetic status, as a means to identify novel mechanisms for enhancing differentiation capacity. The inherent porosity of the nNs, coupled with their ability for cell penetration, will be exploited as a delivery tool for a cutting-edge class of non-coding RNAs into hMSCs to interfere with, and further regulate, epigenetic status and resulting therapeutic potential. This discovery-driven project leverages a one-of-a-kind engineering tool for investigating and manipulating hMSC behaviour. In parallel, the applicant has proposed to undergo a secondment to a UK-based, non-academic partner organisation to enhance his knowledge of intellectual property protection, technology development, and product commercialisation in order to translate his research findings for clinical benefit. The applicant will increase his knowledge base during the project, creating new contacts in his personal network, as well as for the Stevens Group and ICL. This project represents a multidisciplinary, cutting-edge approach to stem cell biology and biomedical engi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Single-Atom Photocatalysts Enhanced by a Self-Powered Photonic Glass Reactor to Produce Advanced Biofuels' (GlaS-A-Fuels) under Horizon Europe.

assistant: **Objectives**

The increasing energy demand and the depletion of fossil-fuel reserves, threatening our energy security and the environment, have aroused intense global concern. To mitigate this, the EU aims to become climate-neutral by 2050, by targeting at the next-generation of biofuels from non-land and non-food competing bio-wastes. Butanol (BuOH), heavier alcohols and hydrogen (H2), if produced from bio-ethanol, are promising advanced biofuels due to their high energy content, long shelf-life and, in case of BuOH, compatibility with the current engines and fuel distribution infrastructure. However, their production faces challenges due to the low yields and selectivities during ethanol reforming. GlaS-A-Fuels envisions a holistic approach to transform bio-ethanol to advanced biofuels employing recyclable and cooperative catalysts from earth-abundant elements. The concept is based on the engineering of a light-trapping and light-tuning photonic glass reactor, self-powered by a thermoelectric module, and tailored to amplify the effectiveness of photo-amplified single-atom catalysts. GlaS-A-Fuels aims to harness the full power of the light-activated carriers of photoactive supports by channeling this energy to the surface-exposed transition metal-cation single atom sites. There, via the effective coordination with the reactants and energy matching with their frontier orbitals, solar energy to fuel conversion can be maximized. Metal-metal and metal-support cooperativity, charge transfer phenomena and strongly polarized oxidations states can further contribute to the required enhanced catalytic performances and difficult-to-achieve key reaction intermediates. To develop efficient processes for the production of advanced biofuels, GlaS-A-Fuels will leverage in a concerted way the key e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TowArd demoCRatization Of ev-BAsed Therapies' in the context of a Horizon Europe call.

assistant: **Objectives**

EVerZom has developed a patented, fast, cost-effective, large-scale standardized extracellular vesicles (EV) production process to address the manufacturing issues that hamper EV translation towards clinic. EVerZom has performed a successful platform scale-up to 6L, meeting quantities needed for phase I trials, placing it at least 2 years ahead of known competitors.With numerous European biotechs poised to enter clinical phase, it’s timely to provide industrial players with EV large-scale capabilities. Hence, EVerZom intends to achieve key milestones during the next 2 years including the validation of platform GMP compliance at clinical phase I scale, the scale-up toward late-stage and commercial batch production as well as platform expansion usefulness towards different cell lines. The ACROBAT project will enable us to be aligned with industrial players roadmap, generate early revenues, and achieve our ambition to be a European pioneer and leader in the EV manufacturing market.


**Keywords:** regenerative medicine,platform industrialization,biomanufacturing,exosomes,Extracellular vesicles,Stem cell biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Genomic and Phenotypic Evolution of Bonobos, Chimpanzees and Humans'.

assistant: **Concept**

Humans have two closest living relatives: the well known chimpanzee (Pan troglodytes) and the lesser known bonobo (Pan paniscus). While the lineage leading to humans and the lineage leading to bonobos and chimpanzees split five to seven million years ago, the bonobo and chimpanzee lineages split around one million years ago. Despite such a recent divergence, these two ape species exhibit remarkable phenotypic differences, indicating that inferences about human evolution will require comparative data from both bonobos and chimpanzees. This is also true at the genomic level. For example, in order to understand the extensive variation seen in gene expression within humans, it is necessary to know the extent of variation within closely related species, as well as the level of differences between species. Comparative genomic data is also necessary, for example, to address whether the supposed high rate of human adaptive evolution is exceptional relative to other closely related primates. Thus, in order to better understand patterns of human evolution, we propose to generate a genome sequence for the bonobo and to collect extensive data from chimpanzees and bonobos on: cDNA sequences, variation in coding and non-coding parts of the genomes, expression of mRNAs, microRNAs and proteins in five tissues, and phenotypic parameters in terms of clinical chemistry, and behavioral and cognitive traits. We will combine these data with the extensive data already collected on humans and perform integrated analyses of between- and within-species variation of genomic and phenotypic traits in humans, bonobos and chimpanzees. This will allow us to place the trends seen in human evolution within the context of our closest living relatives and will substantially increase our understanding of h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AN INNOVATIVE FILTER AID PRODUCT & INTEGRATION SYSTEM FOR THE SUBSTITUTION OF THE KIESELGHUR FILTER AID & REDUCTION OF UNDESIRABLE SUBSTANCES (MYCOTOXINS) IN BEVERAGES, SUCH AS BEER & WINE”' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The proposed DEMYBE project (filter aid-fine particles of the size of 50 μm average) has been conceived upon the needs of the reduction of mycotoxins, such as ochratoxin A (OTA), in everyday beverages (particularly beer and wine) and at the same time to substitute the Kieselghur filter aid. The aims of the proposed DEMYBE project are: to substitute the currently used carcinogenic Kieselghur filter system (currently used in 95 % of brewery worldwide) in regards to health and environmental issues that cause during the application/disposal of the filter aid in the brewery/vinification process and the removal of 80 % of OTA, from the end products. The new product will be made from natural vegetable fibres.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Diagnosing vulnerability, emergent phenomena, and volatility in man-made networks'.

assistant: **Concept**

The aim of the project is to assemble, develop and apply complementary mathematical methods to analyse large, man-made multi-element infrastructure systems that exhibit, so-called, complex behaviour. The scope of the project concerns the network of networks that comprise Europe's critical infrastructure; concentrating primarily on the built environment, energy supply and emergency response systems. The linking themes between these widely differing systems will be the common needs for both qualitative and quantitative prescriptions required to gain insight into the processes that generate complex behaviour. This will assist in the development of civil emergency preparedness strategies as well as in the general long-term planning of civil infrastructure programmes. The reason for including such interdisciplinary topics is the insight that researchers working in a given field may bring to problems that have the same qualitative nature in another, seemingly unrelated, area; thus enabling a macroscopic overview of the complex behaviour of key infrastructures. The themes running across the individual subject areas will be vulnerability, volatility and emergent phenomena. In addition to tackling specific real-world problems, the project will provide a generalised view of how specific classes of topology, coupling laws, and interdependencies affect their vulnerabilities (or conversely robustness) to unexpected natural, economic or man-made perturbations. The project will make ample use of standard mathematical concepts of complex systems theory; however, new methods will be introduced and tested on real-world networks to measure the vulnerability of agglomerate networks systems to widespread propagation of failures, we shall also study the role of feedback and scaling as driver