RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CROss-DIsciplinary knowledge transfer for improved Natural hazard ASsessment' under Seventh Framework.

assistant: **Concept**

The assessment of natural hazards is of the uttermost importance but because of its multidisciplinary rarely manages to incorporate all the relevant strands of evidence. Several mathematical formalisms have been proposed (including for instance Bayesian Belief Networks and Event trees) but the problem of ""filling"" these formalisms with data, knowledge and especially of fully taking into account the ""human dimension"" of the necessary multidisciplinarity remains widely open.  In order to tackle this problem we propose a three-way staff exchange program between the University of Udine, Italy, the National Museum of Natural Sciences, Madrid, Spain, and St. Petersburg State University, Russia. Over the last years these three institutions have been collaborating on topics related to natural hazard assessment. The University of Udine has a long record of joint work with the National Museum of Natural Sciences in Madrid mainly devoted to volcanic hazard, but site effects, and the corresponding risk assessment, are assuming growing importance in the collaboration. Lately, a new formalism for risk assessment, based on both logical and probabilistic inference, has emerged as a result of collaboration between St. Petersburg State University and the University of Udine. This formalism is a step ahead from Bayesian Belief Networks, and is currently one of the major advances in probabilistic risk assessment.  The staff exchange program should empower our mutual collaboration and make the ongoing research a success. We plan mutual visits between all participating institutions. Scientifically, we intend to unite the site effects research and geophysical considerations developed in Madrid and Udine with the logical and probabilistic framework developed in St. Petersburg. The three in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle'.

assistant: **Concept**

Vitamin D deficiency has significant implications for human health and impacts on healthy growth and development and successful aging. Fundamental knowledge gaps are barriers to implementing a safe and effective public health strategy to prevent vitamin D deficiency and optimize status. ODIN will provide the evidence to prevent vitamin D deficiency in Europe and improve nutrition and public health through food. By establishing an internationally standardized analytical platform for 25OHD, ODIN will measure the distribution of circulating 25OHD and describe the prevalence of vitamin D deficiency in Europe. Using available biobanks and databases from National nutrition surveys ODIN will delineate the relative contributions of sun and dietary sources of vitamin D to circulating 25OHD. In support of planned EFSA revisions of vitamin D recommendations, ODIN will carry out three RCT in pregnant women, children and teenagers and a fourth RCT in ethnic immigrant groups to provide experimental data to specify vitamin D intake requirements. Using dietary modeling, innovative food-based solutions to increase vitamin D in the food supply through a combination of bio-fortification of meats, fish, eggs, mushrooms and yeast will be developed and ODIN will test the efficacy and safety of these products in food-based RCT varying in scale from small product-specific trials to a large total diet study in vulnerable indigenous and immigrant sub-groups. ODIN has assembled the largest critical mass of prospective adult, pregnancy and birth cohort studies to date and will conduct meta-analyses and individual subject-level meta-regression analyses to integrate standardized data on vitamin D status, a priori defined clinical endpoints and genotype to examine relationships between vitamin D and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Individual Specialisation in Established Biological Invasions: importance and Ecological Impact' (ISEBI).

assistant: **Innovation**

Differences between individuals are the substance on which natural selection acts; and individual variation has been identified in many ecological dimensions including diet, habitat use and other behavioural traits. It is therefore surprising that this variation is rarely considered within an invasion biology framework, particularly given the enormous biological and economic costs imposed by established invasive species – those introduced by humans that aggressively expand outside their native range. Little is known about how individual traits influence established invasions, to the extent that it has been argued that either bold, highly competitive individuals, or individuals that are cautious and less aggressive, may be successful. The impacts of different individual invader phenotypes as risks for native biota are also largely unknown, yet this knowledge is key for effective management. This project will, for the first time, determine: i) the extent, covariance and persistence of variation in multiple traits (dietary, behavioural and cognitive) in individual invasive rats simultaneously and in the wild; ii) the impact of the fundamental ecological processes of competition and predation on effective trait combinations i.e. individual phenotypes; iii) the consequences of different phenotypes for native biota. With invasion rates continuing to increase globally, this multidisciplinary approach draws upon cutting-edge techniques from behavioural ecology, comparative psychology, conservation and invasion biology. It provides novel empirical tests of theory, examining hypotheses untested in individual invaders or individuals of any species in natural contexts. The results will have important implications for theoretical understanding of natural selection, and will integrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'OsteomiR-Test – An In-Vitro Test for the Diagnosis of Osteoporosis and associated Fracture Risk' (OsteomiR) targeting Horizon 2020.

assistant: **Abstract**

TAmiRNA aims to commercialize an in-vitro diagnostic test that is intended to predict fracture-risk in case of osteoporosis. The OsteomiR-Test meets an urgent clinical need by combining superior diagnostic performance with a simple test principle, thus, ensuring cost competiveness, good scalability and commercial success.Osteoporosis is a chronic skeletal disease characterized by systemic loss of bone strength and consequently high incidence of bone fractures. Osteoporotic fractures constitute one of the most common and costly health problems in the European Union (EU): costs related directly to fractures were EUR 24.3 billion in 2004 and will rise to EUR 76.8 billion by 2050 due to increasing life expectancy. Effective fracture prevention can be achieved through exercise, diet and drug treatment, but depends on reliable early prognosis of fracture risk. Currently, bone mineral density and clinical factors are the basis for prognosis of fracture risk. However, the low specificity of these tests limits efficient fracture prevention and creates an urgent clinical need for novel and better tests.The OsteomiR-Test measures a proprietary combination of circulating microRNAs from standard blood samples. The analyzed microRNAs provide a direct readout of bone metabolism, stress and biological age, and have been demonstrated to have a strong association with fracture-risk. It is a robust, easy-to-use test with good scalability. In order to commercialize the OsteomiR-Test, a detailed assessment of a market entry strategy is required. Therefore, TAmiRNA will i) develop health economic models to prioritize EU-countries for market launch, (ii) identify suitable manufacturing and distribution partners, (iii) define a strategy for IVD regulatory approval and, (iv) conduct a freedom-t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Pulses in active and nonlinear metamaterials' (PEARL).

assistant: **Innovation**

Electromagnetic pulses have ubiquitous applications as information carriers, and the continuously increasing demand for larger capacity of information channels, faster data transmission and high resolution real time imaging necessitate novel approaches to pulse generation, transmission and exploitation in functional devices. Artificial electromagnetic materials (metamaterials) have opened new avenues for controling the properties of waves in the engineered media. The periodic and quasi-periodic layered semiconductor structures constitute a novel class of composite materials, which can offer a novel means for the design of innovative microwave and THz applications using pulsed signals. The main objective of this project is to investigate the properties of pulses in active and nonlinear artificial media composed of periodic and quasi-periodic arrangements of semiconductor, ferrite and metal layers. The theory of nonlinear three-wave interaction in pumping regime in a periodic nipi and periodic and quasi-periodic magnetoactive structures will be developed and the resonance phenomena improving second-harmonic generation efficiency will be analysed. The effects of external biasing fields, pumping, layers' parameters and geometry on the properties of pulsed signals in the semiconductor based metamaterials will be investigated in millimetre, THz and optical frequency ranges. The expected outcomes will give insight into the pulse propagation phenomena in the semiconductor based active and nonlinear artificial electromagnetic materials and provide the conceptual basis for the waveform control of the pulsed signals in the physical layer of hardware and the new applications ranging from ultra-wideband (UWB) communications to THz sensors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Surface Acoustic Wave wireless sensors for High Operating Temperature environments' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Surface Acoustic Wave (SAW) technology has been applied for more than 20 years to develop sensors exhibiting unique capabilities with limited ageing effects resulting in long term stability properties. During the 90s, they have proved their capability to be wirelessly operated without any on-board power supply. In parallel, the long term development of advanced material, particularly in Russia, has yielded a new class of material, namely Langasite and its variant forms, that can be substituted to quartz and lithium niobate particularly when operating at high temperature. Our project will demonstrate wireless SAW sensors operating in an unprecedented temperature range. This sets extreme challenges to all parts of the sensor system since the developed wireless system will be suitable to operate in harsh environments. The great progress brought by the project takes advantage of a consortium involving complementary major academics and industrial actors of SAW-sensor-based systems capable to successfully face the challenges of implementing a whole system allowing for physical metrology in harsh conditions. Substantial improvements will be provided for sensing physical parameters in a wide temperature range (-20°C to +650°C), in monitoring a nano-based production process and other applications. Significant knowledge will be generated in nano-sciences and nano-technologies linked to SAW physical sensors and materials for industrial applications. Demonstration of the system will be achieved at an industrial level for monitoring physical parameters under high pressures and high temperatures. The SAWHOT project consortium is set up on the basis of a bilateral Russian-European partnership generating a unique workforce cooperating within the FP7 framework to address this challenge.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Microfluidic systems for the study of living roundworms (Caenorhabditis elegans) and tissues' (MEMSforLife).

assistant: **Concept**

This proposal situated at the interfaces of the microengineering, biological and medical fields aims to develop microfluidic chips for studying living roundworms (Caenorhabditis elegans), living cultured liver tissue slices obtained from mice, and formaldehyde/paraffin-fixed human breast cancer tissue slices and tumors. Each type of microfluidic chip will be the central component of a computer-controlled platform having syringe pumps for accurate dosing of reagents and allowing microscopic observation or other types of detection. From an application point-of-view the work is focused on five objectives: (i) Development of high-throughput worm chips. Our goal is to build worm tools that enable high-throughput lifespan and behavioral measurements at single-animal resolution with statistical relevance. (ii) Linking on-chip microparticles (beads) to the C. elegans cuticle. We will use beads with electrostatic surface charges and beads that have a magnetic core for quantification of locomotion and forces developed by the worms. Moreover high-refractive index microspheres will be used as in situ microlenses for optical nanoscopic worm imaging. (iii) Realization of a nanocalorimetric chip-based setup to determine the minute amount of heat produced by worms and comparison of the metabolic activity of wild-type worms and mutants. (iv) Study of precision-cut ex vivo liver tissue slices from mice, in particular to evaluate glucose synthesis. The slices will be perifused with nutrients and oxygen in a continuous way and glucose detection will be based on the electrochemical principle using microfabricated electrodes. (v) On-chip immunohistochemical processing and fluorescent imaging of fixed clinical tissue slices and tumorectomy samples. These systems aim the multiplexed detection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unraveling the impact of immune heterogeneity on disease spread in ant societies' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In social species, frequent interactions among individuals increase the risk of disease transmission. Insects rely on innate immune defenses based on conserved molecular pathways, but immune competence varies due to genetic and environmental factors, affecting not only individual susceptibility but also the potential for onward transmission. In social insects, additional behavioral defenses, collectively termed social immunity, reduce disease spread through grooming, corpse removal, and avoidance of infected individuals. However, these group-level defenses may mask or modify the effects of individual immune variation, complicating our understanding of infection dynamics in social contexts. To what extent social immunity can buffer or amplify individual immune differences, and how immune heterogeneity among group members shapes collective disease outcomes, are questions that remain largely unexplored.This project will investigate how immune variation scales up to influence pathogen transmission in the clonal raider ant Ooceraea biroi, a model well-suited for immune manipulation and behavioral tracking. I will generate immune-suppressed (CRISPR/Cas9 knockouts) and immune-enhanced (immune priming) phenotypes, and combine them with unmanipulated wild-type ants to create groups with controlled levels of immune heterogeneity. Using bacterial and fungal pathogens, I will track infection outcomes, mortality, and behavioral interactions with automated video analysis.The results will clarify whether immune heterogeneity amplifies or mitigates disease spread, and whether its effects arise primarily from physiological protection or from collective behaviors. By bridging molecular, behavioral, and epidemiological perspectives, this work will advance our understanding of disease ecol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nanostructural Control of Self-Assembling Polymeric Systems: Optimization of Properties for Technological Applications.' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The framework of this research project is the study of self-assembling processes at nanometre scales in polymer-based systems. In particular, the project expect to obtain a broad control of the Nan structure in technologically important polymers through the knowledge of self-assembling processes in them and variation due to the presence of Nan additives such as carbon annotates and manacles. To carry out the non-structural part of this project real space techniques (atomic force microscopy) and reciprocal space techniques (scattering techniques) will be employed. From the dynamics point of view, relaxation techniques will be used to study the molecular motions and the obtained information will be used to predict behaviour patterns in self-assembling processes. The results are expected to be technologically important in the field of preparation of templates for Nan technology applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Gamete and embryo cryobanking for the preservation of threatened endemic fish'.

assistant: **Innovation**

Populations of fish species endemic to the Iberian Peninsula have been declining since the mid-20th century due to several factors such as habitat loss, water quality deterioration or presence of alien fish species. Furthermore, with the tendency for global warming, the typical summer droughts in Iberia are expected to become more intense and extended in time, so this fact could pose an additional extinction risk factor for the native fish. In this regard, from the 26 native species of the Portuguese freshwater fish, around 70% are already under threat according to the IUCN.Cryo-Fish will progress on basic knowledge of the reproductive biology of endemic freshwater ichthyofauna, assessing for the first-time gamete quality throughout the breeding season. New techniques for gamete assay and protocols for cryopreservation will the purpose of creating a genetic resource bank for biodiversity preservation. From the point of view of basic research, Cryo-Gamete is going to reveal unknown aspects of breeding cycle of the most endangered cyprinids, providing data that will help ex situ conservation captivity programs. The data that will be systematically collected and analysed will create knowledge on the right timing to collect gametes and how to manage them to assure artificial propagation of species in captivity. On the other hand, this proposal wishes to lay the groundwork for making a genetic resource bank of the most endangered fish species at national level. In this regard, new gamete cryopreservation protocols will be designed for the project goal species, being possible to have a wild-phenotypic backup of each population. Finally, Cryo-Fish is going to approach a novel technique located on the frontier of scientific knowledge: fish embryo cryopreservation. This techniqu