RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of synaptic networks in songbirds' under Horizon 2020.

assistant: **Concept**

Vocal learning in songbirds is a complex sensorimotor behaviour with many established parallels to human speech and language learning. Here we aim to resolve the neural ultra-structure of a key premotor area in the songbird brain, HVC (proper name). HVC plays a major role in song learning and takes part in both song perception and production. To understand the neural mechanisms of tutor song memorization and emergence of stereotyped adult song, we plan to map the networks of HVC’s afferent and efferent synaptic connections and to explore the experience dependence of these connections during tutor-based song learning. Electron microscopy (EM) is a valuable approach for detecting synapses in densely labeled brain tissues. However, one of the main challenges of EM is to identify topographic origin of synapses as well as pre- and postsynaptic cell types. I plan to address this problem by combining EM and light microscopy using correlative array tomography (CAT), a technique for visualizing projection neuron networks (projectomics). CAT involves multiple steps of labeling, staining, scanning, and correlating datasets, which is a feasible but time consuming workflow. As high-risk addition to my plan of using CAT, I will also apply expansion microscopy (ExM) to this projectomics problem. The ExM approach is based on physical expansion of fluorescently labeled biological tissue prior to light microscopic imaging. ExM holds the promise of extremely efficient imaging beyond Abbe’s diffraction limit, which may allow it to replace EM for certain applications such as visualizing synaptic connections. ExM is a promising yet unexplored new tool for projectomics research and avian neuroanatomy in general.  We will use ExM, CAT, or a combination, to resolve central and peripheral networ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Characterization and modelling of dietary effects mediated by gut microbiota on lipid metabolism' in the context of a Seventh Framework call.

assistant: **Objectives**

Dysregulation of lipid homeostasis is related to multiple major global healthcare problems today, including aging, diabetes and cardiovascular disease. It has already been shown that nutritional modulation of lipid homeostasis via direct supplementation, e.g., n-3 fatty acids, or via indirect mechanisms, e.g., dietary polyphenols, has beneficial effects on human health. There is growing evidence that ether phospholipids such as plasmalogens play a central role in mediating the beneficial effects, but the underlying mechanisms are not understood.   ETHERPATHS will develop systems biology tools that will facilitate studies of dietary interventions aiming to modulate lipid homeostasis. Specifically, we will develop (1) models that enable studies of gut microbiota and its effect on host cell metabolism, (2) dynamic models of systemic lipid metabolism, and (3) pathway reconstruction methods to study tissue-specific effects of dietary interventions. All models will be optimized in the context of studies of dietary interventions and will be integrated into a sophisticated software platform. In silico strategies will be complemented by multiple experimental approaches, including (1) dietary interventions involving n-3 fatty acids and polyphenols, combined with tracer studies in vitro and in vivo (2) in vitro colon model (3) in vivo germ-free and conventional models of altered lipid metabolism, specifically of plasmalogen deficiency.  ETHERPATHS includes academic and industrial partners with combined unique expertise in information technology, bioinformatics, metabolic and physiological modelling, systems engineering, biochemistry, microbiology, lipid metabolism, metabolomics, obesity and metabolic syndrome, and clinical nutrition. We expect the ETHERPATHS tools to be broadly ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural studies of yeast RNA polymerase III' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

During gene transcription, RNA is synthesized from a DNA template by DNA-dependent RNA polymerases (Pols). Eukaryotic cells contain three nuclear RNA polymerases, responsible for the synthesis of ribosomal RNA (Pol I), pre-messenger RNA (Pol II) and small RNAs including transfer RNAs (Pol III). The three RNA polymerases differ in subunits composition.Whereas Pol II has 12 subunits, Pol III consists of 17 subunits ranging from 10 to 160 kDa. With a total molecular weight of nearly 700 kDa, Pol III is the largest and the most complex nuclear RNA polymerase. Of the 17 Pol III subunits, ten are unique to Pol III, five are common to all three eukaryotic RNA polymerases, and two are shared by Pol I and III.Whereas the crystal structure of Pol II is known, and a n electron microscopic structure of Pol I is available, there is no structural data on Pol III, despite its important roles in regulating cell growth and differentiation.Here we propose to study the three-dimensional structure of the Pol III enzyme by X-r ay crystallography, to obtain novel insights into the mechanisms of transcription, the specific features of Pol III structure and function compared to the Pol II system, and into the evolution of the transcription machineries.Pol III will be purified from yeast strains, and crystals of the entire complex will be sought with the use of a nanoliter robot. Complexes of Pol III with initiation factors and nucleic acids will be prepared for future analysis by cryo-electron microscopy. The studies will benefit from the expertise on Pol II structure determination in the institute.A structural description of Pol III will be of central importance to the large community concerned with gene expression and its regulation, and will contribute to the further development of structur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Mapping the Cell'.

assistant: **Innovation**

A key challenge of systems biology is to understand how genes function as networks to carry out and regulate cellular process. Many important insights have emerged in recent years from studies using the yeast Saccharomyces cerevisiae. A partial genetic-interaction network has been compiled using double knockout mutations. Analysis of this network has provided many important insights about gene function and human genetics and disease.   We will use reverse engineering principles to map cellular processes in yeast, in collaboration with the University of Toronto and the Sanger Institute. By disrupting an unknown process in diverse ways and observing the effects, a model for how the process works can be deduced. For this project, chemical compounds and genetic mutations will be used to perturb the yeast cell, and we will analyse their effects on growth rate. This ‘chemical genomic’ method has already been proven successful as it revealed important new connections in the DNA damage repair process in yeast.   The Giaever and Nislow groups in Toronto have developed two chemical genomic assays called HIP and HOP assay which can measure the perturbation on the cell due to the presence of chemical probes. We plan to apply computational chemistry techniques to help streamline the process of finding and understanding the effects of new chemical probes using HIP and HOP screening technology. More importantly we will also apply bioinformatics techniques to extract meaningful network information from the results of the HIP-HOP assays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced materials and manufacturing technologies for photocatalytically active surfaces' under Fifth Framework.

assistant: **Concept**

Semiconductor photocatalytic films open up a variety of green" technologies with important new applications, e.g. auto-cleaning surfaces, elimination of organic contaminants, anti-bacterial properties, purification of air, photovoltaics, rain shedding - leading to the improvement of quality of life, health and safety. SCP materials and processes have potential to be a major new emerging exploitation technology however, to date, wide application has been hindered by the lack of materials and coating technologies. This proposal targets achieving SPC materials with a higher activity, functionality, durability and sensitivity -plus innovative large volume coating technologies, including nano-technologies. Three application demonstrators will prove their wide potential. The 14 participants from 6 countries will develop the first significant European industrial application of SCP technology in a wide range of industries."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ACE Creative: Harnessing the strengths of innovation multipliers to accelerate creative industry growth through an integrated ecosystem of supports in finance, market access and technology exploitation.' (2014-2020) under Horizon 2020.

assistant: **Objectives**

InnoCreate is an ambitious coordination and support action aiming to stimulate the growth of the creative industries in Europe by overcoming challenges at individual SME level (small size, problems with access to finance, barriers to new market entry…), at the innovation support level (disparity in availability and quality of support) and at overall creative industry level (fragmentation, localisation…).  InnoCreate will respond by networking innovation support players and harnessing their regional strengths into a European ecosystem of supports to respond more effectively to SME needs.  Two specific end user groups of SMEs will be targeted through InnoCreate: creative industry SMEs exploiting advanced technologies and ICT SMEs innovating in the field of creative industries. Both of these target groups will be equally supported.  SMEs will benefit from an imaginative programme of communication and support actions: InnoCreate will piggy-back on the Creative Business Cup to raise awareness about the ICT Challenge competition, network SMEs throughout Europe at the InnoCreate International Camps and provide customised one to one supports for the most promising SMEs with high growth potential.  InnoCreate galvanises existing structures by bringing together three strong existing European networks – EBN, CKO and the ECB Network and a network of innovation multipliers at regional level. The InnoCreate service offering aims to be immediately accessible online and ‘on-site’ in 15 EU partner and associate partner countries with a target of engaging further stakeholders to deliver the support services in all EU member states by the project end. The impact of InnoCreate will be tangible – for individual SMEs, for innovation support actors and for the growth of the European creative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Diffractive optical elements for sensing applications'.

assistant: **Objectives**

Research objectives and content This proposal is to explore the performances of surface-relief gratings in novel diffractive devices, capable of generating synthetic infrared spectra which could be used as chemical sensors for correlation spectroscopy. Such elements have continuous-relief profiles and can be fabricated by a computer controlled laser direct writing system, capable of locally modulating the exposure dose released to a sensitive film. A single lithographic process will produce a surface-relief, ready to be transferred into the substrate by dry etching. Hence, classic alignment difficulties, existing in standard multi-level fabrication processes, will be skipped. The applicant's work is divided in two main tasks: a) Realization of an optimisation software program for designing the desired diffractive function, using scalar and rigorous diffraction theories,. b) Fabrication and testing of the diffractive element resulting from the previous design step Training content (objective, benefit and expected impact) a) Realization of smart, diffractive sensors capable to detect the presence of gases even if they are harmful or difficult to handle. b) Know-how transfer toward local research students, through the applicant's supervision of a couple of degree thesis in this field. Links with industry / industrial relevance (22) Even if no direct industrial links exist at this stage, the host institution is already involved, in programs with Italian industries, for realizing surface-relief devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Infrastructure for Marine and Inland Water Research' in the context of a Horizon Europe call.

assistant: **Objectives**

The overall objective of the project is to develop a virtual environment equipped with FAIR multi-disciplinary data and services to support marine and freshwater scientists and stakeholders restoring healthy oceans, seas, coastal and inland waters. The AquaINFRA virtual environment will enable the target stakeholders to store, share, access, analyse and process research data and other research digital objects from their own discipline, across research infrastructures, disciplines and national borders leveraging on EOSC and the other existing operational dataspaces. Besides supporting the ongoing development of the EOSC as an overarching research infrastructure, AquaINFRA is addressing the specific need for enabling researchers from the marine and freshwater communities to work and collaborate across those two domains. A specific goal of AquaINFRA will be to develop an EOSC based research infrastructure combining the marine and freshwater domains, which will include the development of a cross domain and cross-country search and discovery mechanism as well as building services for spatio-temporal analysis and modelling through Virtual Research Environments. A set of strategic use cases including a Pan-European use case as well as more focused use cases in the Baltic Sea and the North Sea will provide the setting for co-designing and testing services in the targeted research communities. The AquaINFRA project results are expected to contribute to the utilisation of EOSC as an overarching research infrastructure enabling collaboration across the domains of marine and freshwater scientists and stakeholders working on restoring of healthy oceans, seas, coastal and inland waters.


**Keywords:** Ocean, freshwater, biodiversity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Green operations with Geometric altitude, Advanced separation and Route charging Solutions'.

assistant: **Objectives**

Since the early days of aviation, barometric pressure measurements have been a simple and robust method for altimetry. Two drawbacks exist though: there is no direct reference to terrain, and the constant variations in pressure caused by the weather lead to increased vertical profile variability restricting capacity and flight efficiency in today’s high traffic density. One goal of Green-GEAR thus is to investigate the environmental potential of geometric altimetry enabled by satellite navigation, increasing safety and eliminating waste of airspace by removal of the transition layer and supporting more environmentally friendly climb and descent operations.With the safety case for the change of separation definition already open, not only integration of manned aviation with drones (that are already using geometric altimetry in current operations) can be addressed but Green-GEAR will also look at the potential for increasing capacity through reduced vertical separations enabled by geometric altimetry.Last but not least the project, will investigate the potential of environmentally driven route charging, with new mechanisms for charging airspace users to incentivise minimum climate impact. Route charging will reward those who avoid volumes of airspace with a high climate impact and disincentivise flight planning through high demand sectors / flight altitudes except where it optimises environmental benefit overall, while being cost neutral to airspace users and passengers on average. Added capacity in the “greener” volumes of airspace enabled by reduced vertical separations limits necessary flight plan modifications, furthering acceptance of the approach.The combination of these three topics in Green-GEAR not only raises substantial synergies and ensures a harmonised approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Black hole dynamics and the origin of supermassive black holes' under Horizon Europe.

assistant: **Concept**

Every massive galaxy in the Universe contains a supermassive black hole in the center, which has grown from a smaller black hole, a so called seed black hole. Galaxies must have acquired their seed black holes in the early Universe, to allow for the observed long coevolution between black holes and galaxies, but recent research has shown that the dynamics of seed black holes in early galaxies are complex, and that seed black holes struggle to find their way to the center of future host galaxies.For this project, I propose the first large-scale study of seed black hole dynamics in the early Universe. I will use my extensive expertise in numerical simulations to design a high-resolution simulation able to fully resolves seed black hole trajectories. From this simulation, I will create the first large-scale catalogue of high-redshift black hole seed dynamics for different black hole formation models. I will use this unique dataset to understand galaxy seeding, determine the relative importance of different seed formation mechanisms and make observational predictions for the James-Webb Space Telescope (JWST) and Laser Interferometer Space Antenna (LISA). These upcoming major observational campaigns will soon provide an unprecedented wealth of observational data on black holes and their host galaxies in the early Universe, making the proposed project extremely timely. With this work, I will challenge the standard paradigm of rapid seed black hole delivery, and lead the way towards a paradigm shift in our understanding of the origin of supermassive black holes.


**Keywords:** supermassive black holes, early universe, dynamics, simulations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Interactions in Community Treatment' to be submitted under Seventh Framework.

assistant: **Abstract**

The goal of the project INTERACT (Interaction in Community Treatment) is to explore practices of face-to-face communication and social interaction used to implement Therapeutic Community (TC) programmes in the area of addiction recovery. The concerns for the continuing marginalisation of vulnerable people expressed in EU documents (e.g. Europe 2020, Green Paper “Improving the mental health of the population”) make it timely and crucial to carry out research that identifies practices by which vulnerable people can be encouraged and supported to engage socially, to express their views, and to actively collaborate in the design and implementation of activities that can satisfy their own needs. The project will address questions that have not been addressed in previous research. (1) How can TC educators foster client members’ participation and social involvement in TC programmes? (2) What are the obstacles and dilemmas that they meet in this process and how do they deal with them? (3) How is it possible to improve the educators’ practices so that the clients’ active involvement in the rehabilitation process is not hampered? The project will focus on three TCs, and will analyse a corpus of recorded professional-client multi-party interactions. The method of Conversation Analysis will be employed to identify the communication roadblocks and dilemmas that characterise the implementantion of the TC approach to addiction recovery. Such dilemmas can influence the practices carried out at the micro-level of day-to-day rehabilitation and support activities, which have an impact on the lives of vulnerable service-users. An expected outcome is to sensitise political and professional stakeholders to the possible challenges entailed in the delivery of social support programmes. The dis