RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Dynamic hormone diagnostics'.

assistant: **Objectives**

We propose to revolutionize current endocrine diagnostics by replacing conventional, time-consuming single-analyte hormone assays with ambulatory dynamic endocrine diagnostics. Disorders of the adrenal and pituitary endocrine systems are not only accompanied by changes in absolute hormone levels, but also secretion patterns. The rapid circadian (24 hour) and ultradian (< 24 hour) cycling of hormone levels poses diagnostic challenges since random measurements do not always detect abnormalities. Furthermore, monitoring of treatment of endocrine diseases are often severely limited by lack of multiple measurements at different time points, which is impractical in an out-patient setting.To overcome these hurdles academic and commercial partners propose to: • Develop a novel microdialysate sampling and analysis system for adrenal and pituitary hormonome profiling• Validate the method in healthy vs. six populations with endocrine disorders • Promote the system for demonstration in routine clinical practice by dissemination of results to relevant European stakeholders The portable fraction collector for subcutaneous microdialysate combined with state-or-the-art ultrasensitive assays by liquid chromatography tandem mass spectroscopy (LCMS/MS) and multiplex proximity extension assays (Proseek), will allow collection of 10 minute fractions for up to 72 hours while the person tends to daily life activities. LCMSMS and Proseek assays can generate a timeline of “hormonomes” covering the 24 hour cycle without losing sensitivity and specificity, producing not only hormone levels, but also secretion patterns for diagnostics and monitoring purposes.ULTRADIAN will deliver an ambulatory diagnostic system with unprecedented sensitivity and specificity for simplified diagnostics and monitori
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Biocatalytic solar fuels for sustainable mobility in Europe'.

assistant: **Concept**

Photofuel studies and advances the biocatalytic production of alternative liquid transportation fuels, which require only sunlight, CO2 and water. Microbial cells directly excrete hydrocarbon and long chain alcohol fuel compounds to the medium from which they are separated, without the need to harvest biomass. This significantly improves the costs and energy balances as only a minimum of nutrients is required for self-replication of the biocatalyst, whilst cell harvesting, drying and lipid extraction is omitted. Such minimum-input systems are compatible with operation on degraded or desert land which avoids the pitfalls of most of the currently available biofuel technologies. The products are drop-in fuels that fully or partially replace their fossil counterparts without the need for new infrastructure. To set a benchmark for alternative solar fuels, three research groups will collaborate in the advancement of the biocatalysts from TRL 3. The best biocatalytic system(s) will be up-scaled and operated outdoors in photobioreactors modified for direct fuel separation at a scale of several cubic meters (TRL 4-5). The identification of optimal future fuel blends with a fossil fuel base and Photofuel biofuels as additives, as well as the analysis of performance and emissions in car or truck engines, will be evaluated by the oil- and automotive-industry partners. The entire pathway will be assessed for environmental and economic performance as well as social acceptance of large scale production in rural communities and by the consumer. All results will be combined to a business development plan, which clearly identifies the opportunities but also the challenges prior to an economic fuel production in compliance to the EC Fuel Quality Directive.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '3D Liver Organoids: Modelling Host Hepatitis B Virus Interaction' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

An estimated ~400 million people are chronically infected with hepatitis B virus (HBV) infection worldwide, resulting in an estimated $658 million in medical costs and lost wages annually. Although HBV disease can be prevented by vaccination, many people still become infected. Potent and safe drugs are available to eradicate HBV viral particles and clinically ‘cure’ HBV infection. However, during replication HBV delivers a very stable form of viral DNA (covalently closed circular DNA, cccDNA) in the nucleus of the hepatocyte, causing life-long risk of reactivation of HBV infection in case of suppression of the immune system (e.g. chemotherapy). Therefore the pharmaceutical industry is now aiming to develop strategies to eradicate the virus from the infected liver completely. Such studies are hampered by the lack of appropriate in vitro or animal models due to the narrow tropism of HBV for human hepatocytes. The hypothesis of the project is that creation of 3D culture systems encompassing hepatocytes, hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) derived from an inexhaustible source of cells (human pluripotent stem cells (PSCs)) in a matrix that mimics the biophysical and biochemical features of the liver, will be a superior model for the study of HBV infection and evaluation of the efficacy of antiviral drugs.  We also hypothesize that such 3D organoids will improve maturation and function of hepatocytes, HSCs and LSECs.The proposed studies are highly interdisciplinary, merging expertise from biology, to biophysics and engineering, with inter-sector mobility, networking, collaboration and knowledge transfer between academia and industries. The knowledge developed will be disseminated by presentations at consortium meetings, international c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Earth-abundant metal-containing photosensitizers for sustainable photodynamic inactivation in plant protection and food safety' in the context of a Horizon Europe call.

assistant: **Objectives**

In the world, the phrase ""we are going through a major food crisis"" is becoming more and more common. This is because our society is faced with managing an exponentially growing world population and a decrease in arable land per person. This rising demand for food in developing countries is at risk due to plant diseases induced by bacteria, fungi and viruses. At the same time, food is traded globally, enabling the dissemination of dangerous microorganisms worldwide. Therefore, creating alternative and ecologically friendly antibacterial and antifungal treatments is essential to address the growing demand for safe and healthful plant-based foods. EcoPDI aims to solve this current and critical problem by developing new earth-abundant metal compounds with natural ligands as photosensitizers for photodynamic inactivation (PDI) of resistant bacteria and fungi. For this, EcoPDI focuses on the ""Sustainable-Economic-Applicable"" triple approach. Thus, this multidisciplinary project will develop new sustainable treatments that avoid the use of pesticides and employ sunlight to activate the antimicrobial activity of the compounds, will use cheap earth-abundant metals and improve the disadvantages of natural compounds, and apply the new photosensitizers directly to plants through the planned secondment. EcoPDI includes both the transfer of knowledge to the host institution and the training of the candidate in new techniques and methods. The findings have the potential to open up space for additional basic and applied research on PDI in plant protection and food safety. This proposal responds to the European Green Deal which has as its objective to restore damaged ecosystems and bring nature back across Europe and reduce the use and risk of chemical pesticides by 50% by 2030.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Holomorphic Evolution Equations' (HEVO) targeting Seventh Framework.

assistant: **Abstract**

The scope of this project is to study  holomorphic evolution equations and the associated dynamical systems, both from the local and the global point of view. In particular we aim to study general Loewner equations (both autonomous and non-autonomous) and applications to dynamical systems, in one and several complex variables. In one variable we plan to develop a general version of SLE's for non-slit evolutions and apply to physical and others problems. In several variables we plan to develop the general theory, together with applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Disrupting Aberrant Protein–Protein Interactions with Conformationally Constrained Hydrocarbon α-Helical Mimetics' to be submitted under Horizon 2020.

assistant: **Abstract**

Many critical processes within cells, including those that control whether a cell lives and divides or dies, are mediated by protein–protein interactions (PPIs). In certain disease states, such as cancer, these interactions can become defective in a way where disruption of the interaction has therapeutic benefit. Replacement of one of the protein partners, which often have α-helical secondary structure, with a small molecule is one method of disruption; however, the interface can often be large and shallow, making the design of competitive small molecules challenging. The saving grace is that the interaction energy is usually dominated by the interactions of a few amino acid residues, which protrude from one or more faces of the α-helical peptide. The design of α-helical mimetics that are non-peptidic in nature and that can replicate the positioning of these hotspot residues has been an active area of research. The host laboratory has recently developed a method to prepare chains of substituted carbon atoms with complete control of absolute and relative configuration. Owing to the avoidance of syn-pentane interactions, the all-syn and alternating syn–anti contiguously substituted chains fold into well-defined helical and linear conformations. The positioning of the substituents could uniquely replicate a pattern of hotspot residues that cover two or more faces of an α-helical peptide. This project will explore this possibility through the design, preparation and testing of mimetics that target the Mcl-1/Noxa-B PPI, which controls apoptosis and has leucine, arginine, isoleucine, aspartic acid, and valine at positions 11, 12, 14, 16 and 18 as hotspot residues. The project merges cutting-edge synthetic organic chemistry, multiple forms of computation, including molecular m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Silicon nanowire fabrics for high energy density batteries' (SiNERGY) under Horizon 2020.

assistant: **Objectives**

Meeting European energy storage in transport, stationary and emerging sectors requires annual cell capacity of at least 200 GWh in the next 5 years, calling for urgent development of new materials for LIBs that increase energy/power density at lower costs. Silicon, an abundant material with 10-fold higher capacity than graphite, has shown promise as anode material when appropriately nanostructured. The challenge is in producing nanostructured Si networks using simple and scalable processes leading to thick electrodes that are ultimately economically feasible. SiNERGY addresses this challenge by proposing a new simple method for continuous production of nanoengineered self-supported electrodes for high energy density and durable LIBs, with potential performance nearly an order of magnitude above commercial anodes.


**Keywords:** Silicon, nanowire, fabric, synthesis, anode, battery, energy, electrode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'De novo design of affinity, specificity, and multispecificity in synthetic protein interaction networks', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The two most fundamental features of molecular recognition are affinity and specificity. The proposed research aims to develop a new methodology for de novo design of small interaction networks not seen in Nature and to generate such networks with predetermined levels of specificity and affinity. In Preliminary Results we developed a methodology to de novo design protein binders of surfaces that have not been structurally characterized in bound form. We used this method to design three experimentally validated medium-affinity binders of the apo form of an acyl carrier protein (ACP), which has no co-crystal structures, demonstrating that interaction design could target a broad range of physicochemically appropriate surfaces. This synthetic network is the first multispecific system (one ACP interacts with three unrelated proteins), which is completely devoid of selective pressures for function other than binding, and will serve as a model to study how high affinity, specificity, and multispecificity might arise from non-interacting proteins. We will develop a multidisciplinary computational/experimental approach to substantially increase the affinity of the ACP to its binders by introducing stabilizing substitutions to residues on either one or both sides of each designed interface. Affinity will be further increased by experimental in vitro selection of higher-affinity variants of the ACP or of its partners. We will additionally erect specificity barriers between the ACP-binder pairs by redesigning the amino acid identities and backbones of interfacial loops. Specificity and affinity are important features in many protein-engineering applications, including the development of protein therapeutics and diagnostics, and the generation of synthetic signaling and metabolic ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Classes of combinatorial objects: from structure to algorithms' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The proposed project aims at analyzing fundamental problems from combinatorics using the most current methods available and at providing new structural and algorithmic insights to such problems. The problems considered will be treated on a general level of classes of combinatorial objects of the same kind and the developed general methods will also be applied to specific open problems. Classes of dense and sparse objects will be treated using different techniques. Dense combinatorial objects appear in extremal combinatorics and tools developed to handle them found their applications in differentareas of mathematics and computer science. The project will focus on extending known methods to new classes of combinatorial objects, in particular those from algebra, and applying the most current techniques including Razborov flag algebras to problems from extremal combinatorics. Applications of the obtained results in property testing will also be considered. On the other hand, algorithmic applications often include manipulating with sparse objects. Examples of sparse objects are graphs embeddable in a fixed surface and more general minor-closed classes of graphs. The project objectives include providing new structural results and algorithmic metatheorems for classes of sparse objects using both classical tools based on the theory of graph minors as well as new tools based on the framework of classes of nowhere-dense structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Effectiveness of facility-based audits to improve the responsiveness of West African district hospitals to obstetric emergencies: a three-country cluster randomised controlled trial' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Identifying and implementing sustainable interventions to improve the quality of hospital care in sub-Saharan Africa is challenging. Maternal and perinatal mortality ratios stagnate at a high level; improving hospitals' responsiveness to obstetric emergencies is thought to be an important potential contribution to decrease them. WHO will soon launch an initiative to promote a range of quality assurance strategies, including several types of facility-based audits. While audits certainly hold promise, the evidence for their effectiveness is mixed.All randomised controlled trials of audits have been undertaken in industrialised countries, but the effectiveness of health services intervention is likely to vary according to context. We propose a cluster-randomised controlled trial in West African district hospitals to assess the effectiveness of two types of facility-based audits, criterion-based clinical audits (CBCA) and patient-centred case reviews (PCCR). WHO guidelines on the management of obstetric complications and enhanced routine documentation including the WHO pantographs will be introduced in all 36 participating hospitals, while CBCA or PCCR will be set up in 12 hospitals each.The primary outcome variable is a responsiveness score, designed to measure technical and organisational management of obstetric emergencies. Additional outcome measures include the delay between decision and start of emergency caesarean section, and hospital based perinatal mortality. A concurrent anthropological study will improve our understanding of how audits work or why they fail and identify barriers and facilitators for their successful integration into routine practice. An economic evaluation will assess the cost-effectiveness of both interventions. We are confident that the trial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MathInGreaterParis Fellowship Programme' to be submitted under Horizon 2020.

assistant: **Abstract**

Research in mathematical sciences plays a key role in competitivity and growth, and in facing new challenges as numerous future technologies and complex societal questions are relaying on advances in mathematics. France has a long tradition of excellence in mathematics research and education, and Greater Paris Region represents the largest concentration of mathematicians in the world, with incredible successes. However, the Region still suffers from a relative dispersion. The Greater Paris’ mathematical community, namely FSMP (Fondation Sciences Mathématiques de Paris covering all laboratories in Center/North of Paris), FMJH (Fondation Jacques Hadamard in Paris South) and Fédération Bézout (in Paris East), have decided to join forces in the present ambitious Cofund MathInGreaterParis Fellowship Programme. The 60-month project is split over 3 calls of 2-year fellowships, offering a total of 74 years of fellowships. The MathInGreaterParis objective, as a single and unified portal to Greater Paris Region, is to attract the brightest Experienced Researchers in mathematical sciences. The training activities will focus on: 1) Research, transferable skills and career development, 2) International, interdisciplinary and intersectoral secondments in research and/or teaching, 3) Wider impact of research concentrating on competitivity and outreach. They will be helped in building their future, whether in the academia or towards new industrial challenges. They will be taught how to communicate with society and become truly “Math Ambassadors”, based on “learning by doing approach”. MathInGreaterParis fellows will emerge new ambitions, educate a mindset oriented towards more mobility and curiosity, a greater awareness of the mathematics’ impact in the new economy, a greater taste for