RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Feasibility study for the establishment of electronic information services for direct marketing in EC' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

DM-On Line is a feasibility study for the establishment of electronic commerce for SME direct marketing organizations. Direct marketing is a process creating direct information and transactional relationships between companies and consumers, and companies and other businesses. Over the last few years, direct marketing practice has been embraced by dozens of different industries from the traditional mail order companies to charities, governments, publishing, retail and travel.Many of the users of direct marketing are SMES AS ARE OVER 90% of the suppliers to the industry. Direct marketing is the fastest growing element of the communications business accounting for over 50% of all marketing expenditure in established markets, generating in excess of two trillion dollars of global sales.At the heart of the direct marketing process is the collection, management and activation of data enabling one to one relationship marketing.The many facets of the direct markkketing process embrace information technology whether it be computerization, digital imaging, telephony, EDI, internet, intranet and satellite broadcasts.With such an amorphous and growing industry, co-ordination, benchmarking and sharing of information and processes to improve competitiveness has been highly fragmented. As a result, the DM On-Line project will examine the feasibility of two key areas.Firstly, to identify the practical information needs of the industry to facilitate competitiveness locally and in cross-border marketing. This would include the identification of new markets, regulations, laws, best practice, research, opportunities billboard", knowledge of congress and trade fairs, common education standards and distance learning, case history libraries, assistance in getting started in direct marketing,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Target binders'.

assistant: **Innovation**

We want to further develop our tools and technologies for high-throughput research, with the final goals being (I.) the particle-based combinatorial synthesis of 1 Mio different peptides on a glass slide for chemical costs of ~50€ (KIT, CBL, MS, TUV), and (II.) the labelling-free parallel readout of binding affinities by a variant reflectometric interference spectroscopy method for ~10.000 peptide spots per cm(+2) when staining the array with an unlabeled protein (BIA, KIT). These tools provide the basis (III.) for a standardized, fast, and reliable high-throughput procedure that we want to develop in order to find high-affinity peptide binders against any pharmaceutically interesting target protein. Such a procedure might have an important impact in medicine and in the biotechnology industry. In order to achieve this goal, we will use display techniques that in combination with high-throughput sequencing typically will identify ~100.000 putative peptide binders per target protein (ISO). These will be synthesized in array format to validate binding to the target protein by an independent method (PPP, DKFZ). Next, based on binders from initial screens, many variant peptides are synthesized in high-density array format for iterative screens (PPP, DKFZ, KIT), whereby massive parallel labelling-free detection of binders pinpoints higher-affinity binders (BIA). In order to validate our novel high-throughput procedure, (IV.) we want to find high-affinity peptide binders against relevant target proteins (delivered by APO and OXF), and test these binders in biological assays (OXF, APO).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a clinical diagnostic tool for cochlear lesions based on otoacoustic emissions' in the context of a Sixth Framework call.

assistant: **Objectives**

At least 85% of the estimated 160-million hearing-impaired people of Europe suffer from malfunction of the cochlea. Malfunction remains largely untreatable because function is not fully understood. Initiatives are required to develop more powerful, clinical tools to diagnose cochlear malfunction. However, this demands a better understanding of function. It is known that the basis of cochlear function is mechanical and that, in the healthy cochlea, mechanical processes send vibrations back tithe middle ear, causing pressure changes in the ear canal, called otoacoustic emissions (Oases).Although Oases are routinely used in clinical diagnosis, their full potential is far from being realized, because neither the basic cochlear mechanisms nor the OAE generation mechanisms are fully understood. Therefore, the scientific aim of this project is for the proposed Fellow, Dr. A. Beatnik, to develop a realistic model of the mechanics of the human cochlea under normal and pathological conditions, enabling him: i) to provide an artificial experimental medium for interpretation of observed properties of Oases, and ii) to design a novel stimulus paradigm for Oases to improve their clinical diagnostic value. In an ongoing project using cutting-edge technology (a variant of atomic force microscopy), Dr. A. Beatnik will be trained by the host institution to measure the nanomechanicalproperties of the cochlea in an animal model. He will use this data to improve his already established, innovative model of cochlear function, using it to design a more powerful stimulus paradigm for the generation of Oases in humans that will uncover pathological, mechanical processes in the cochlea. Drag. Beatnik will work together with clinicians in the host institution to gather OAE data in human subjects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Improvement of sustainable phaseolus production in Europe for human consumption'.

assistant: **Concept**

Phaseolus (Phaseolus spp.), in spite of its agronomical, ecological and nutritional advantages, is still an underexploited crop in European agriculture. Although research is covered by several European groups, the so far limited possibilities for cooperation and the absence of a common overall goal - the strengthening of the position of Phaseolus in European agriculture - can be observed. Since most of the current problems in the EU concern all the different bean species and production purposes it was agreed during two preparatory meetings, to consider Phaseolus .spp in general, independent of the species and the final product. The OBJECTIVES of PHASELIEU are: * to analyze the potential and opportunities of Phaseolus beans for European agriculture * to identify and describe the constraints preventing a wider distribution of Phaseolus beans in European agriculture * to develop integrative strategies in order to improve the adaptation of Phaseolus beans to European growing conditions aiming at a sustainable producti For the development of integrative strategies PHASELIEU will focus on the following ISSUES:  * genetic resources: improvement of the management of genetic resources at European level (in cooperation with the European Cooperative Program/Genetic Resources - ECP/GR of IPGRI) and widening of the genetic basis of Phaseolus in Europe including interspecific hybridization * transformation/regeneration: development of a widely applicable transformatio protocol for Phaseolus * molecular markers: development of molecular markers for use in Phaseolus breeding * breeding: plant health (biotical and abiotical stress): improved non-chemical methods of crop protection * quality: increased nutritional and organoleptic quality and improved cooking characteristics * field tria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'geohazards and geomechanics' to be submitted under Seventh Framework.

assistant: **Abstract**

This proposal aims to bring together the complementary expertise of world leading groups carrying out research on the engineering assessment, prevention and mitigation of geohazards, the main ones being floods, landslides, and earthquakes considering also the effect of climate change and human activity on soil degradation.To mitigate these disasters it is necessary to improve our understanding of the failures taking place in flood defence embankments, to have better models for a more rational risk assessment of areas prone to flooding, to investigate the geomechanical conditions leading to the onset of landslides more in depth, to model debris flows and mudflows to estimate run-out distances and destructive power of the landslide materials, etc. In other words, prevention, preparedness and mitigation of geohazards rely on sound geo-engineering which requires competences in geomechanics, numerical modelling, constitutive models for soils, hazard zonation and risk assessment.The goals of this proposal are: i) to investigate the key aspects of major geohazards (floodings, landslides, earthquakes) to bridge the current gaps in knowledge to improve significantly the current capabilities of prevention, preparedness and mitigation by bringing together specialists engaged in cutting edge research; ii) to enable knowledge exchange among experts in complementary research fields; iii) to train several Early Stage Researches (ESRs) to expand their knowledge during their stay at the host institution; iv) to improve the current normative standards and codes ruling geohazard prevention; v) to generate new approaches to the problems dealt with through exposure to different methodologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced traffic management solutions for synchronized and resilient multimodal transport services' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The European transport faces major challenges in terms of traffic congestion, safety, greenhouse gas emissions and its derived costs. In addition, the development of disruptive technologies and emergence of new mobility solutions generate a revolution in transport network and traffic management.SYNCHROMODE aims to develop data driven ICT tools for improving the management of transport operations from a multimodal perspective and managing the overall transport network as a whole. SYNCHROMODE will provide to transport managers new predictive and network optimization capabilities for balancing the transport supply and demand, and capable of reacting to different types of events. The project will research in transport network supply& demand modelling, simulation and prediction of future states; optimization techniques for multimodal traffic optimisation, standards for data collection and storage; new governance models in transport management and new approaches for defining KPI for assessing the overall solution.SYNCHROMODE will deliver a suite of services for improving the overall transport network management, fostering the coordination of different agents involved in the provision and control of the transport services, the services are: 1) Transport network-wide data exchange and integration system; 2) Cooperative dashboard for real-time monitoring and prediction of network-wide multimodal transport and traffic; 3) Resilient multimodal transport network and traffic management support tool.SYNCHROMODE system will test and validate its results in 3 real Case studies, Thessaloniki (GR), Netherlands and Madrid (SP), with real data from various modes of transport under different traffic events, such as bottlenecks, accidents etc.


**Keywords:** Network and Traffic Management;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Artificial Cells with Distributed Cores to Decipher Protein Function' in the context of a Horizon 2020 call.

assistant: **Objectives**

We envision a future where ‘chemical apps’ on mobile devices produce on demand valuable compounds for health and performance as well as apps for bioagent threat detection and disease.  To take concrete and defined steps toward this future vision, we will exploit the miniaturization provided by lab on a chip technology and construct responsive architectures and metabolism based on living cells and tissues.  We will build programmable and re-configurable, (bio)chemical processes, with precision, order, and as hierarchical cellular constructs, in the same way as living systems. We will enable microscale, liquid-based, chemical compartmentalisation (cores), and inter-compartmental (core-core) communication, just as one finds in organelles, cells and tissues. ACDC will focus on developing this next generation technology through a detailed workplan that heavily involves the nontrivial tasks of integrating diverse state of the art technologies including microfluidics, microwave resonators, DNA-based supramolecular assembly, in vitro gene expression and the integration of membrane channels into a functional platform. In a future embodiment of this project, artificial cell technology will be used as programmable and reconfigurable matter for specific applications, including theranostics and personalized medicine as well as sensing and actuation in the environments for bioremediation.As the first steps towards that future vision, we aim to produce an artificial technological construct and process that recapitulates some aspects of living systems on the microscale, and therefore this project will produce exemplars of secondary living technologies concentrating on the wetware class [1] but also a multi-level mathematical framework.  We have assembled an international, interdiscipli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Elucidating the molecular mechanism by which BTN3A3 mediates host restriction against zoonotic influenza virus infection.' (FluZoBa).

assistant: **Innovation**

Avian influenza viruses (AIV) pose a constant socio-economic threat to humanity due to their potential to cause novel pandemics. This risk is underscored by recent reports of mammalian species infected with highly pathogenic strains of AIV. To develop effective drugs and improve risk assessment, a detailed understanding of the molecular mechanisms of AIV infection is crucial.AIV are typical emerging zoonotic pathogens capable of crossing into new species. This depends on two factors: i) the new host must support viral replication, and ii) restrictive factors that inhibit infection must be evaded. One significant barrier to AIV infections in humans is the limited activity of avian-adapted viral ribonucleoprotein complexes. These complexes consist of one genomic RNA segment, nucleoproteins, and a viral polymerase. Recently, the host factor BTN3A3 was identified as a critical restriction element for zoonotic AIV, influencing cross-species viral evolution. However, the exact mechanisms through which BTN3A3 restricts the virus, and how the virus evades this restriction, remain unclear.This study involves structural investigations conducted directly within infected cells at nanometer resolution by in situ cryo-electron tomography, an approach that is significantly pushing beyond the current state-of-the-art thereby setting new paradigms in the understanding of molecular infection mechanisms. The primary objective is to elucidate how viral host-adaptation mutations evade BTN3A3 restriction with the overarching goals to i) improve pandemic risk assessment tools, ii) reveal new drug targets, and iii) serve as a proof-of-principle for studying restriction factors during infection with other zoonotic viruses.This research will be conducted under the supervision of Dr. Petr Chlanda
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'THE ROLE OF RNA SILENCING IN REGULATION OF JASMONATE HORMONE SIGNALLING' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

RNA silencing and jasmonate (JA) signalling are key pathways that regulate plant development and defence against pests and disease. Evidence indicates that these pathways interact, but the full extent and nature of the interactions are unknown. An accurate understanding of these interactions is crucial to inform crop modification strategies that improve plant defence and growth. RNA silencing targets specific genes using small (s)RNAs. It controls gene expression through processes such as DNA methylation, which affects binding of transcription factors (TFs) to promoters, and mRNA degradation. JA signalling may influence DNA methylation via RNA silencing, and expression of hundreds of genes changes during JA responses. Also, JA signalling is inhibited by disruption of RNA silencing. I propose to conduct a targeted dissection of JA signalling/RNA silencing interactions. I will be hosted first by Prof. Ecker (Salk Institute, US), who is a world leader in DNA methylation research. There, I will investigate JA-responsive changes in DNA methylation at a genome-wide scale. I will also study a group of TFs that regulate both RNA silencing and JA signalling, and investigate the roles of known RNA silencing components in JA responses. In the return phase, I will be hosted by Prof. Solano (Centro Nacional de Biotecnología, Spain) who is an expert in JA biology. Whilst in his group I will characterize novel JA-responsive sRNAs and investigate the effects of JA-responsive DNA-methylation on known JA-signalling TFs. These objectives will reveal new insights into two critical plant defence pathways, making an important contribution to the EU Knowledge Based Bio-Economy. Through significant international mobility, I will learn cutting-edge techniques, broaden my scientific knowledge, d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Meta-rules and constitutional law: 'co-regulating' legislative processes in Europe?' (METARULES).

assistant: **Innovation**

Given the fundamental importance of legislation to society, legal scholarship has generated remarkably few insights into the norms that effectively govern legislative processes. Between the extra-legal constraints traditionally studied by political science and the formal constitutional framework that is the territory of constitutional law scholarship, a grey area of seemingly bureaucratic rules on lawmaking can be identified. This project refers to these rules as ‘meta-rules’ and aims to analyse the way they interact with constitutional law.  The recent proliferation of ‘Better Regulation’ policies in Europe has led to a convergence of meta-rules applied in different legislative arenas and to a growing salience of these norms. Many meta-rules overlap with constitutional norms in terms of subject matter, for instance the issue of who gets access to the legislative process. However, these rules are inspired by the paradigm of the regulatory state rather than by the traditional rationale of democratic lawmaking. An example of a meta-rule is ‘a legislative proposal can only be put forward if it is accompanied by an impact assessment’. Such a requirement follows a different logic than the assumption that ‘the sovereign parliament can initiate laws as it sees fit’ which is often part of traditional constitutional frameworks. Are meta-rules as they emerge from increased transnational cooperation in the framework of EU ‘Better Regulation’ capable of overriding the formal constitutional rules and principles in certain cases? Or do they instead facilitate their implementation in the day-to-day practice of lawmaking? It is proposed to combine macro-level research on meta-rules by expanding existing databases on regulatory policies in Europe with more detailed case-study based anal