RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Coordination between cell identity, tissue mechanics and proportionate patterning during vertebrate eye formation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The development of an organ requires the precise coordination between pattern formation, morphogenetic movements and the final size of the system. Significant progress has been made in understanding these processes independently. The aim of this proposal is to integrate this information by analyzing coordination hubs, such as the crosstalk between YAP/TAZ and Wntβ-catenin pathways during the specification of the identity and the mechanical properties of the cell. I will use the development of the vertebrate eye as a defined paradigm. To identify intrinsic and relevant properties of this system, the two most powerful and amenable models of eye morphogenesis will be analyzed: the self-generation of 3D optic cups from mouse Embryonic Stem Cells and the in vivo development of the teleost eye. The plan is to generate a spatiotemporal activation map of the main determinants of eye identity and use them to link morphogen signaling with key morphogenetic processes in specific cells. This will be the groundwork to identify the role of retinal pigmented epithelial (RPE) cells during optic cup folding, the context that I will use to understand both the coordination between morphogen patterning (Wnt) and mechanical properties (Yap) of the retinal precursors, and between proportionated patterning and eye size (scale-invariant mechanisms). This proposal relies on the collaboration of multiple experts from the host institute and on the use of already developed bona fide protocols, reporter lines and signaling perturbations experiments, but revisited with cutting-edge technologies, such as light sheet microscopy and computational modeling. Thus, it is an extremely innovative but feasible project to understand deep-root questions of organ formation. Moreover, this interdisciplinary proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Generation and validation of a panel of EMT reporter cell lines from solid tumors' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cancer is a very heterogeneous disease and its subtypes display great variability in their response to treatment. The high failure rate of anticancer drug discovery consumes billions of dollars annually, contributing to the high cost of those few drugs that are eventually approved. One of the problems lies in inaccurate and oversimplified cell line models for studying human tumors. Yet, a method to incorporate tumour subtype contribution in response to drugs is lacking. To improve experimental oncology and drug discovery, we propose to develop a validated toolkit of ready-to-use cell lines and defined cell culture media in order to clearly and unambiguously represent well conserved solid tumor subtypes. This approach is drawn from our ERC StG-funded project, in which we invented, validated and patented a method to genetically label any cell type or cell state transition. Our idea is novel because it uses custom synthetic genetic reporters in in vitro tumor models, which enables tracing of tumor cell states. The first component of the kit is a set of genetically modified cell lines representing tumors from different epithelial tissues and reporting on epithelial or mesenchymal states (work package1; WP1). Thereafter, we will use these cells to define the formulation of two additional components of the kit: i) the cell culture media and ii) the supplements to in vitro propagate and discriminate the two distinct cell states (WP2-WP3). In WP4, we will perform a product comparison, by measuring the features of the toolkit cell lines in response to anti-cancer treatment as compared to current standards. In parallel, WP5-WP6 will address industry-quality, IP strategy implementation and freedom-to-operate. Given the socioeconomic impact of cancer and the lack of a similar techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fibre Optic Strain Monitoring at Elevated Temperatures' to be submitted under Fourth Framework.

assistant: **Abstract**

Expected deliverables:The primary deliverable was to be a prototype optical fibre instrument to measure the strain of power plant structural components operating at elevated temperatures. The contributing deliverables were:- Fibre Bragg gratings to operate at temperatures in excess of 5500C and monitor strain.- Transducer to efficiently transfer strain from the component under test to the fibre sensor.- Attachment methods for the transducers - between fibre and transducer and between transducer and component.- Cabling, armouring and interconnection for fibres to facilitate remote monitoring.- Instrument to monitor up to 100 sensors, process information and input to remnant life software.- Full system integration.- Laboratory evaluation and field trial.Project's actual outcome:The project achieved most of the major deliverables outlined above. The system was evaluated within the laboratory. Full field trials were not undertaken. The system was shown to operate effectively and with further development in certain areas a prototype to meet the required specifications can be designed.Objectives and content The integrity assurance of high temperature components in power plant systems is a major problem facing industrial plant operators as existing equipment ages. Owing to uncertainties relating to system stresses, and known incidence of weld and bend failures, the scheduling and directing of maintenance activities has largely been based on comprehensive and frequent inspections. This has led to extended outage or downtime with associated high maintenance costs and availability penalties. The ability to monitor the strain across critical components such as welds and bends, at operational temperatures (550°C) in real time would provide more accurate residual life predictions, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Training the next generation of leaders to deliver innovations in dignified sustainable care systems for older people', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

INNOVATEDIGNITY is a trans-national network that aims to deliver a shared, world-leading research and training programme to educate the next generation of thought leaders with the necessary research experience and transferable skills to deliver innovations in dignified, sustainable care systems for older people, including new care models and digital applications. INNOVATEDIGNITY’s research examines older peoples' perspectives of care systems with a specific focus on dignity, investigates the potential for digital applications, and analyses gender issues to provide crucial, urgently needed knowledge for sustainable and fit for purpose care that supports older people to live well. The network's programme of investigation:  1) Critically evaluates existing care systems and provide analyses that make use of older persons’ insights.  2) Examines and offers a range of conceptual, empirical and methodological conditions to develop new innovations, including digital technology that offer dignity in care. 3) Provides an analysis of impacts of new care models on the wellbeing of older people. 4) Critically examines impacts of gender on care delivery, on the leadership of caring and science careers, and the care workforce with insights for sustainability. INNOVATEDIGNITY addresses the European problem of how ageing people can live well in caring systems with a concentration on cross-disciplinary scholarship, producing an evidence base through fifteen PhD projects, interlinked with a series of integrated assignments, and supported by a coherent interdisciplinary training. INNOVATEDIGNITY will produce leaders well versed in innovating care from standpoints within and beyond ‘healthcare’, sectors that engage technology, the public, policy makers for the benefit of older people in Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Combining CT diagnostic data and interventional approaches for futureproof cardiology care'.

assistant: **Objectives**

Coronary artery disease (CAD) is caused by the pathological process in which fat, cholesterol and calcium accumulate on the arterial wall. It is the leading cause of mortality in the world, affecting in 2019 about 200 million individuals or 2.5% of the global population and resulting in over 9 million deaths annually. The prevalence of CAD in the European Union (EU) reached 5.11% in 2019 . As a result, CAD-related deaths topped 973,000 in the EU in 2019. CAD incidence is expected to rise further due to the increased prevalence of risk factors including obesity, diabetes, and increasing age. For a patient with CAD, the care pathway still involves enormous variability and complexities. Inefficiencies and challenges in the treatment pathway are associated with poorer patient outcomes including recurrent cardiac events, incomplete revascularization in complex patients, and increased risk of mortality in patients with both acute and chronic CAD. Due to the low sensitivity or specificity of the standard diagnostic tests, 60% of CAD patients unnecessarily undergo an ICA, as they are found to have non-significant coronary stenoses and do not require revascularization.Coronary Computed Tomography Angiography (CCTA) uses X-ray technology and computer processing to create a detailed 3D image of the coronary arteries, revealing the degree of lumen obstruction. It provides non-invasive access to the coronary anatomy, also for asymptomatic patients who would normally not undergo invasive coronary angiography (ICA).  Current guidelines adopted in the US, EU, and the UK recommend CCTA as a first-line test for evaluation of CAD, positioning it as a ""gatekeeper"" to the Cath lab.In COMBINE-CT, we will deliver a fully automated, vendor agnostic CCTA-enabled workflow for chronic CAD patie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Isolation and genetic characterisation of new actin binding proteins in the drosophila embryo' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to investigate the molecular events associated with morphogenesis during Drosophila gastrulation. Specifically, the role of actin binding proteins in cell shape changes will be studied. Molecular biology approaches will be developed from epitope display techniques to quickly and efficiently isolate genes encoding novel actin binding proteins based on the affinity of the proteins for F-actin. Subsequently, their function will be examined, and ultimately, mutants will be isolated and analysed genetically.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Europe, the USA, and the Shape of International Legal Order: A comparative study of International weapons restrictions' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The project examines the factors shaping the development of international legal norms regarding the conduct of warfare. Within this broad focus, it tries to illuminate three interrelated issues by combining insights from the fields of international relations, law, and comparative politics. The project seeks to explain the different European and US approaches to humanitarian and security problems and their impact on international humanitarian law in the post-Cold War period. Based on several cases of international weapons restrictions, it tries to show that whereas there are differences on these issues across the Atlantic, they are not inherent in any fundamentally different cultural understandings or military capabilities, but are the product of different distributions of power among actors in those societies and the institutional structures that intermediate among them.The analysis of state positions on the same weapons issues over time aims at explaining the process of gradual development of a Europe an approach toward humanitarian problems and the roles NGOs and EU institutions play in it.The project explores the importance of the distribution of power in the state system, great power legitimacy, and moral values for shaping the laws of war through historical comparisons of international restrictions on weapons with inhumane or indiscriminate effects in three periods characterized by different power distributions (the relative multipolarity of the late 19th century, the bipolarity of the 1970s, and the unipolarity after the Cold War).Pursuing my project at a European institution where I can get additional training in my fields of interest will greatly enhance the quality of my research and career prospects.I hope that it would have important theoretical and policy im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Boosting Investment Readiness of SMEs and Small Midcaps - InvestHorizon' under Horizon 2020.

assistant: **Concept**

InvestHorizon will address the main challenges affecting investment readiness:- the lack of programmes addressing investment readiness across Europe;- the low awareness regarding investment readiness and financing options amongst entrepreneurs;- the weak interest of different investor types for innovative SMEs across the technology sectors;- the weak investability of many of the companies and presentational failings, and; - the difficulty of matching innovative companies with specialized investors.InvestHorizon will pursue the following 5 objectives:1) Identify, recommend and communicate those strategies, indicators, schemes and tools with the best impact on investment readiness and investors sensitization and matching;2) Raise the awareness amongst innovative SMEs across origination types, stages, countries, technology sectors about those key topics affecting their knowledge and capacity to improve their investment readiness; 3) Increase the interest of investors across the range of technology sectors and across the range of different types of (co)-investors;4) Improve the investment readiness of 3000 SMEs by boosting their business and investor propositions as well as their presentation pitch, and; 5) Matching at least 450+ investment ready companies with specialized investors across Europe. The Consortium is composed of 10 partners each with relevant pan-European networks covering public research tech transfer (ASTP-Proton, IULG, UVT), accelerators and incubators (F6S, EBN and BWCON), the SME and Chambers of Commerce (Eurochambres) and the range of investor types (EBAN, European Crowdfunding Network and Europe Unlimited also representing Tech Tour and the International Venture Club).We anticipate that at least 50 companies will be receiving funding for a total amount
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Diversity of signalling within a single neurotransmitter receptor subtype' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Because diverse signalling through a single receptor subtype may occur as a consequence of specific agonist receptor G protein interactions, the aim is to develop new ligands acting via receptors that only activate specific second messenger pathways.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NEgotiation and MEdiation Sensible Issues' Solutions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Inspired by the greek goddess Nemesis, personification of ""Distribution of Justice"", neither good nor bad, simply in due proportion to each according to what was deserved.My research is focused on new dispute resolution methods, applying also new technologies, especially online dispute resolution platforms.Seraphin is an online centre whose proceedings have been entirely digitized. Seraphin is well-known for their arbitration centre, enabling the efficient resolution of commercial disputes, but they are currently developing other platforms for Mediation and Negotiation.Nemesis will focus on the link between the advanced research on online dispute resolution - from an academic perspective - and the real online world - with all the different cases and practical issues to face off on a daily basis - in order to develop a common path with solid research basis, due to the state of the art and best practices acquired during my academic career,and a practical/pragmatic mindset, due to the issues faced everyday on the online Seraphin platforms.This project concerns legal research with interdisciplinary aspects, incorporating insights from disciplines such as computer science, economics, and regulation theory. While scholars and regulators are concerned about forms and numbers of ODR providers, an in-depth study of the practical implications of e-mediation is lacking. This project is among the first to apply academic and practical perspective to e-mediation. The desk research will be enriched with insights from the workshops –an innovative approach for legal research.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'DEVELOPING AND TESTING OF NEW METHODOLOGIES TO MONITOR AND EVALUATE HEALTH RELATED EU-FUNDED INTERVENTIONS IN COOPERATION PARTNER COUNTRIES'.

assistant: **Concept**

EVAL-HEALTH is an R&D project which has as its main goal to contribute to strengthen monitoring and evaluation of European Union (EU) funded interventions in developing countries in the specific area of Health, The major objectives of EVAL-HEALTH are:1) To develop a sound methodological approach to evaluate and monitor implementation and performance of EU funded interventions in developing countries in the health sector by: i) Identifying best practices in M&E aid and their impact on health issues from major international donors and agencies active in the field. ii) obtaining comprehensive insight of the EC funded bilateral interventions in health sector. iii) Developing specific methodological models and tools for M&E of the impact of EU funded bilateral interventions (sector/budget support, Individual projects, R&D actions) iv) Testing on the field the suitability and applicability of the developed methodologies through case studies methodology.2) To understand how the developed tools and methodologies adapts to different EU interventions.3) To disseminate the results obtained in the project to the main project stakeholders as a means to increase and improve European funded interventions effectiveness in the health sector.EVAL-HEALTH is planned as a 46 month R&D project, with 9 participants from Spain, UK, the Netherlands Portugal, South Africa, Nigeria, Thailand,  India and Colombia.The consortium will benefit from the inclusion of three high-level external Advisory Committees (Donors, Recipients and Scientific). These committees will be formed by relevant experts on M&E health aid in developing countries and will provide an important accumulated expertise to the project.As results of the EVAL-HEALTH project, EC Services and development partner countries will have im