RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Production and Testing of humAn-derived Neurons and brain organoids: advanced model probing in neurodevelopmental disorders' (ProTeAN) targeting Horizon 2020.

assistant: **Abstract**

Autism and associated neurodevelopmental disorders are chronic conditions that afflict 1 in 68 children and produce great costs to society. Lack of realistic models has hindered progression in our understanding of these disorders since core pathogenic defects may only arise in the context of complex human neuronal structures. Two recent breakthroughs have now enabled the development of improved models: the identification of stem cells in adult tissue; and the development of human organoids in vitro that allow the study of complex human neuronal networks. The ProTeAN projects aims to combine Neurobiological and Biotechnology research (key field in Horizon 2020), to: i) establish a dental stem cell biobank from autism patients and controls; ii) develop dental cell-derived brain organoids to explore neurobiological properties; iii) perform single-cell sequencing during the organoid generation process; iv) create proof-of-concept applications of brain organoids as a biomedical platform to test drugs. When developed, this platform will dampen the need for animal studies, reduce and contain the costs associated with drug developments and provide personalized medical testing devices with a minimally invasive strategy. This project counts on the applicant’s expertise on stem cells, differentiation and bioinformatics, and on the expertise of supervisor João Peça and collaboration from Lino Ferreira (expert in bioengineering) and Guoping Feng (expert in autism research) to assure the success of all tasks. The applicant has established a career development plan and will partake in outreach activities to engage different target audiences in issues pertaining to this project. An EF-RI fellowship will facilitate the responsibility of spreading the researcher's knowledge to European p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Simple and Smart Energy Communities for All' (SHAREs).

assistant: **Concept**

The Clean Energy for all Europeans package paves the way for an energy revolution by putting the consumer in the driving seat of the green transition process. Energy communities offer the unique opportunity for consumers to form critical mass and become renewable energy producers and offer their demand flexibility to the market. However, the current requirements of becoming a prosumer bear a crucial risk that ultimately there will be a two-speed energy world: those who have the knowledge, access and opportunity to become a prosumer, and those who lack the resources, know-how, education or time to participate in and benefit from the new opportunities. Therefore, there is a clear need to support local heroes (i.e. those interested in setting up collective actions) in establishing their energy community and enable them to motivate and target consumers directly. This is particularly important for countries where energy communities are yet to be established. The concept of SHAREs is simple and straightforward: create a SHAREs Gateway for local heroes to help them initiate an action and grow, which consists of: (1) A country-specific implementation toolkit to equip local heroes with the technical and logistic capacity to set up their energy community (legal framework, such as master contracts, technical and IT solutions, business models, etc.); (2) The building blocks of a tailored “pick-and-mix” communication campaign to enable local heroes to promote their idea effectively to their most relevant consumer groups. The SHAREs Gateway combines the insights and tools from existing initiatives as well as input of established energy communities (pioneers) and policy developers. After having been put to test and refined in at least 20 aspiring energy communities in 6 European count
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Impact matrix analysis and cost-benefit calculations to improve management practices regarding health status in organic dairy farming' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Animal health status in organic dairy farming does not in all respect meet consumers’ expectations. Improvements are crucial to support consumers’ confidence and their willingness to pay premium prices. These are urgently needed to cover the higher production costs. Previous herd health planning concepts have prepared the ground for further advancements. However, recommended measures are often implemented only to an unsatisfactory degree, differing widely between farms, and resulting in an improper animal health status.The IMPRO project aims to substantially overcome weak points in current health management strategies on organic dairy farms and to increase the implementation of evidence based measures and to improve practice of health management. This will be achieved by a multidisciplinary and participatory approach to develop farm specific solutions regarding preventive measures and early treatment strategies. Researchers with a thorough experience in conducting applied research will aim for the following:•to develop a participatory and farm-centric diagnostic tool for a sound diagnostic procedure at the farm level, identifying the most effective measures to improve animal health,•to evaluate farm-specific costs and benefits of recommended measures, to optimise farm-specific allocation of available resources, and to emerge incentives,•to examine the motivation and attitudes of farmer, advisor, and veterinarian directly involved in health management practice,•to elaborate reference values for achievable standards with respect to animal health status,•to develop a pro-active monitoring protocol aiming for improved effectiveness of preventive and treatment strategies and for a reduction in the use of allopathic remedies,•to assess the manageability of alternative treatme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New generation of carbohydrate-based vaccines via rational understanding of their immunological mechanism' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Glycoconjugate vaccines have provided enormous health benefits globally, but they have been less successful in some populations at high risk for developing disease. They are composed by a sugar antigen covalently linked to a carrier protein. The traditional hypothesis of immune activation by glycoconjugate vaccines suggests that only peptides generated from glycoconjugate processing can be presented to and recognized by T cells, and this contribution is crucial for their immunogenicity. In most cases, conjugation processes have been set-up empirically.Recently, new findings offer a rational explanation for how conjugates work and may render vaccine development a more straightforward process. In contrast with the classical mechanism, this new model suggests that carbohydrate presentation to the T cell by antigen-presenting cell may strongly enhance antibody response. The keystrategy is to conjugate the carbohydrate to peptides which anchor the conjugate via MHC class II and allow the sugar epitope to be presented via the T cell receptor. Application of this principle resulted in a GBSIII vaccine strongly protective in a mouse model and 50–100 times more immunogenic than a traditional vaccine composed byrandom linking of the sugar on a protein carrier. Although the principle has been demonstrated much remains to be done to generally apply the concept to generate vaccines for clinical use. In the proposed study, we will extend the approach by analysing different variables (peptide carrier, glycan chain length, conjugation chemistry and microbial antigen), with the aim of using the increased understanding of basic immunological mechanisms to develop a new translational platform for optimized and cost-effective carbohydrate-based vaccines. Innovative strategies of conjugatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GREEN PROCESSING AND VALORIZATION OF ORGANIC BY-PRODUCTS OF DISTILLERIES, AS NOVEL APPROACHES FOR CLIMATE-SMART PROTEIN APPLICATIONS FOR ALTERNATIVE FOOD AND CIRCULAR BIO-ECONOMY' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Food systems have created demand for addressing adequate nutrition, safe, healthy, accessible, and affordable food, under the pressure of increasing trend of the global population (projected to reach 10 billion by 2050), climate changes, pandemics, economic crisis, growth in the dietary supplements segment and many more. Sustainable and cost-efficient development of innovative food sources are needed to meet the projected nutrition demand, which have recently attracted the attention of both producers and consumers. Conversely, the significant losses and waste production by the processing industries are becoming a serious nutritional, economical, and environmental issue. The aim of BionovFOOD project is to propose novel approaches to valorize the distillery organic by-products and to include them into a biorefinery system. These will be used as raw materials in processes aimed at the recovery/separation of bio-products, with a focus on the production of proteins for food application. To reach this goal will be developed on a pilot-demo scale, process concepts for bio converting grape marcs, wine lees and vinasse, generated from the distillery industry, into protein-rich ingredients to be used for the production of alternative food products. Life cycle assessment and techno-economic aspects for the production of protein sources produced from edible and safe fungi will be investigated. With proteins produced will be designed and developed novel food. BionovFOOD project constitute the starting point for the understanding that distilleries’ by-products can significantly contribute to the future production of alternative protein-rich fungal biomass for food applications. Indeed, it will create synergies and co-benefits across 4 priority areas: nutrition and healthy diets; cli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Guide by Telematics to Enable Tourist Freedom at Sites' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

GUIDEFREE seeks to bring customised site information to the independent tourist traveller, every time and at every location, focusing on visits of tourist sites. The user will access the information prior to or during a trip, at any geographical location, to receive immediate description of a site during a visit or decide on a total tourist visit-mobility schedule, i.e., how and when to visit a site and each station/exhibit, or not to visit at all. By supporting intelligent searching and integration of information from different sources, the project maximises individual freedom, increases the effectiveness of all types of tourist visits, promote rationalisation of tourist travel, and allows the reduction of negative effects from structured guidance or lack of information on tourist freedom.Objectives:The objectives of GUIDEFREE are to:- integrate tourism, access, geographical, multimedia and other data for use by tourists prior to and during visits at sites,- adjust and transform the integrated data to suitable format for flexible use by tourists, - assist tourists in using the integrated data,- develop customised data mining methods to aid searching by tourists at sites, and- test and assess the new interactive methods on site, based on mobile and fixed access.Work description:The project will develop and test off-line or on-line:- Integrated databases for use prior to and during site visits by tourists, to improve the effectiveness of tourist information and management systems as indicated by the richness of the project archive and other tourist measures of performance.- Improved customised data mining methods to aid searching by tourists at sites.- Integration of tourist information and management strategies, which, aided by personalised support methods that allow se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Obsidian Anastomotic SafeGuard – A powerful and efficient tissue sealant method for reducing the anastomotic leak rate in colorectal surgery' under Horizon 2020.

assistant: **Concept**

Obsidian ASG® is the first – and only - autologous fibrin tissue sealant applicable for gastrointestinal anastomosis, that will significantly decrease the anastomotic leak rate, following gastrointestinal resection when treating Inflammatory Bowel Diseases (IBDs) or Colorectal Cancer. The current number of anastomotic leak rates is a large societal issue, as studies show rates as high as 19%. Considering that approx. 1.8 million new cases of colorectal cancer will occur worldwide in 2018 (being the 3rd most common cancer type), the number of leaks is astonishing – and this is only for colorectal cancer. Adding the number of IBD patients needing a resection, Obsidian ASG® faces a market potential of 0.79M patients just in Europe, Asia and Oceania every year. Leveraging on this market opportunity, Obsidian ASG® contains all the components needed for on-site prepation and application of an autologous platelet rich fibrin selant – a preparation that can be completed in less than 30 minutes. As the only product in the market, Obsidian ASG® offers 1) a long-term cost-effective procedure for gluing and sealing intestinal stump-ends; 2) A fast and natural stimulation of wound healing that significantly reduces the anastomotic leak rates; and 3) Full biocompatibility, eliminated risk of blood disease transmission and no thrombin or bovine components added to the blood or Obsidian ASG® solution at any time during the process. Yet, to reach market commercialization, we need to conduct a clinical study of Obsidian ASG® with 300+ colorectal pre-surgery patients. The SME P1 grant will be crucial for completing the design of the clinical study as well as setting up key partnerships for the proposed clinical study (to be set up in a SME-2b Instrument Project). As such, the SME-Instrume
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimised Runway Centreline Interception' (ORCI) under Horizon Europe.

assistant: **Objectives**

ORCI will explore innovative AI-based solutions to help increase runway throughput using advanced automation support tools in the TMA domain. Specifically, the objective is to provide key information to Air Traffic Controllers in final approach sectors, to support informed decisions on when to issue vectoring instructions to aircraft for optimal spacing between consecutive arrivals during medium, high, very high-density and increasingly complex TMA airspace operations. To achieve this objective, the project will develop an AI model that is trained using radar surveillance data and ATC voice communications between pilots and controllers.During the project, Barcelona and Lisbon approach operations will be assessed. This will include interviews with ATCO experts from the respective ANSP partners, as well as in-depth analysis of local arrival characteristics (e.g. geometries, procedures, etc.). In addition,  high amounts of radar surveillance and voice communications data will be collected and processed, to support and guide the training and testing of the AI models.The validation of the AI model will be supported by Human in the loop  and Fast Time simulation techniques (using the  RAMS Plus tool) to ensure that the performance of the AI model is evaluated in a realistic and controlled environment, and to get some initial human performance and safety related feedback.The successful implementation of the AI model is anticipated to optimize delivery of vectoring instructions, leading to enhanced capacity, efficiency, environmental performance, and overall improvements to arrival air traffic management that are consistent with SESAR performance targets. Additional benefits also extend to optimization of the runway throughput by reducing both ATC workload and the potential for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Greensand without organic additives for the production of iron castings (GO-APIC)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The idea to the project is generated in the EU-Thematic Network-Foundry Waste. The organic materials used as binders and additives in the mould sand cores for the production of iron castings create severe working environment and external environment problems. Coal dust is an additive used in greensand (clay bonded moulding sand). 80% of the iron castings produced are made in greensand moulds containing coal dust. The rest is made in organic chemical bonded moulds. Avoiding coal dust or other organic coal dust substitutes will create a more healthy and clean working environment in the iron foundries and at the same time give a sand waste far less contaminated with organic compounds more suitable for reuse in other industries. The objectives are to improve the environment, by the development of a new greensand for high production moulding in iron foundries by using inorganic additives instead of coal dust, giving as good castings quality as ordinary greensand. The objectives will be advanced through laboratory RTD, pseudo-industrial test casting, prototype test in industrial scale, and intensive dissemination of the results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'European network to develop new therapeutic strategies for Parkinson's disease using lentiviral vector technology'.

assistant: **Innovation**

Parkinson's Disease (PD) is the second most common neurodegenerative disease. The recent identification of genes underlying familial PD (alpha-synuclein and parkin) opens perspectives for a better understanding of the disease. (N) EUROPARK proposes to develop new cell culture and new animal models for PD based on these two genes using optimised lentiviral vector technology. Lentiviral vectors are efficient tools to transfer genes into the brain. Using lentiviral vector technology we will explore the role of alpha-synuclein and parkin in the pathogenesis of PD, which will enable rational development of new therapies. The potential neuroprotective role of parkin will be used as a new gene therapeutic approach. The established disease model systems will allow evaluation and validation of new gene therapeutic strategies and new drugs for the treatment of PD.