RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The church of the Holy Apostles at Constantinople: the MYth and its Reception across the CEnturies' under Horizon 2020.

assistant: **Concept**

MYR<i>CE aims at contributing to the study of the cultural history of Byzantium and the dissemination of its memory across the centuries, by considering a major monument – the church of the Holy Apostles at Constantinople – and the symbolism associated to it. The objective of the research is to understand the reason why this monument occupies a crucial place in Byzantine and Mediaeval times. To seize the specific status of this monument, I will run an investigation into a set of sources referring to it (textual, iconographic) and follow the paths of its dissemination across time and space. My twofold training in philology and art history will be essential for the analysis of the material relevant to the case and for the successful accomplishment of MYR<i>CE. For the first time, the enforced analysis will treat the monument as a historical element, inserted in the process of cultural transmission, thus giving a significant contribution to shifting traditional scholarly focus away from the mere consideration of its architectural forms. The methodology adopted will promote cultural historical modes of investigation, opening new avenues of research for the field. Given the importance of the example chosen, this project is potentially entitled to become a reference model for other comparable case-studies. MYR<i>CE comes appropriately timed, in a moment in which the monument is drawing again scholarly attention. The mobility plan proposed will allow training at EPHE to acquire the methods of questioning textual and visual material from an historical and anthropological perspective, in order to understand the topic proposed in its cultural specificity, and residence at UNIVE in order to develop the hermeneutical part of the study and to access textual and monumental sources (S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Institutionalizing global genetic-resource commons. Global Strategies for accessing and using essential public knowledge assets in the life sciences' (GENCOMMONS) targeting Seventh Framework.

assistant: **Abstract**

There has been a dramatic increase in interest in commons in the last 10 to 15 years, from traditional commons managing the use of exhaustible natural resources by fixed numbers of people within natural borders, to global information commons, dealing with non-rival, non-excludible goods by a potentially limitless number of unknown users. The emerging global genetic-resource commons fits somewhere in between, shifting in the direction of information commons as digital-information infrastructures allow physically distributed collections to be networked in virtual global pools. In this research project we propose that networking pools of genetic resources in a global commons potentially is a workable alternative to proprietary market-based solutions, which have been shown to be unable to generate sufficient investment in the vast quantities of genetic resources that are neglected because of their unknown and/or unlikely commercial value. These neglected resources are the building blocks for future scientific research and have enormous value for sustaining biodiversity and livelihoods in developing and industrialized countries. Our hypothesis is that implementing collective intellectual property strategies and standard material transfer agreements for access to these pre-competitive research materials has become feasible in a cost effective manner through new hybrid approaches to governance which combine design features from natural resource commons and digital information commons. To substantiate these proposals, this research project will conduct a comparative institutional analysis of the use and exchange practices in the genetic-resource commons, and propose a set of governance arrangements that would put these practices on a sound legal and institutional basis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel biotechnological route for the isolation and investigation of rhamnogalacturonan-I from apple side-streams as model systems' (RHAPPLE), addressing dissemination and exploitation.

assistant: **Impact**

As much as 50% of the fruits and vegetables produced globally are wasted, and so are their valuable nutrients. Fruit and vegetable waste mostly consists of primary plant cell walls, which are fibrous and recalcitrant composites of a load-bearing cellulose-cross-linking glycan network as being embedded in a more soluble matrix of polysaccharides, with pectin being the most abundant class of macromolecule within this matrix. Crude pectin extracts are used for a variety of food applications. While the functionality of pectin is sufficient for most current applications, the contribution of different pectic molecules, or structures within the same molecule, to its functionality is still poorly understood, as some structural elements are susceptible to degradation by common pectin extraction procedures. Galactose, rhamnose and arabinose, which form the rhamnogalacturonan-I (RG-I) hairy region within pectin molecules, are acid-labile, explaining the extensive debranching during conventional extraction methods and the low amounts of RG-I in current pectic ingredients. RHAPPLE aims to explore a novel biotechnological route for the selective isolation of intact RG-I from our designated model system apple pomace. We will investigate the application of yeasts that have been genetically modified to secrete a set of enzymes degrading other plant cell wall polysaccharides. We subsequently aim to provide the crucial knowledge on the structure-function relationships of RG-I and unlock its use as hydrocolloid, binding platform, and prebiotic. RHAPPLE is thus a cross-disciplinary project, involving microbiology, molecular biology and physico-chemistry tools. Our fundamental research within precision fermentation will position RG-I as one of the most promising hydrocolloids and prebiotics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'International collaboration to extend and advance grid education' (ICEAGE).

assistant: **Concept**

ERA is investing heavily in e-Infrastructure (e-I) to stimulate industry, improve the lives of citizens, accelerate research and gain international competitive advantage. For Europe to realise this expectation, there needs to be a diverse, knowledgeable, creative community, skilfully exploiting e-I. ICEAGE will catalyse the necessary infrastructure and skills by establishing a worldwide initiative to inspire innovative and effective Grid Education (GE). By GE we mean not only education in the use of the Grid, but also the use of the Grid in education. We use the term Grid" in a broad sense to include computing technology, working practices and policies that underpin e-I.Good education in rapidly advancing scientific domains is particularly labour intensive. It must draw on the expertise of a small community of pioneers. A major objective of ICEAGE is to provide an effective mechanism for distilling their knowledge and rapidly propagating it across Europe. ICEAGE will create a forum to bring together experts worldwide to expand and advance GE. Building on EGEE, ICEAGE will enable students and educators to obtain and develop GE via sustained, large-scale, multi-purpose e-Is. ICEAGE will demonstrate the wide potential of Grids, revealing new creative and business opportunities and leading to the inclusion of social, ethical and economic issues in educational programmes. ICEAGE will show clearly how education can benefit from e-I.ICEAGE will deliver a programme of educational events. Its outcome will be the adoption by European Universities of courses in many disciplines to support the deployment and exploitation of e-I. ICEAGE will ensure that citizens are well prepared to use e-I in their private and professional lives. It will stimulate European educators by closely coup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Accelerating the commercialisation of printed triple mesoscopic perovskite solar cells through ferroelectric nanocomposites' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Printed triple mesoscopic perovskite solar cells (TM-PSCs) have excellent potential to be a commercially viable photovoltaic (PV) technology: they are easily manufactured at scale avoiding expensive materials or processes. They are also intrinsically much more stable than alternative PSC technologies – a major advantage as stability concerns must be overcome to induce confidence in emerging PSC products. However, TM-PSCs have not reached the power conversion efficiency (PCE) levels achieved by conventional single-junction, thin-film PSCs (27% compared to 20% for TM-PSCs). Therefore, new approaches are needed to overcome the challenges of charge-carrier recombination and open-circuit voltage (Voc) losses that hinder the efficiency of TM-PSCs due to the non-ideal perovskite crystallisation within their porous scaffolds, and non-ideal interfaces. PriMe-Ferro will explore a new approach to boost the efficiency of TM-PSCs towards commercially viable levels. It will integrate ferroelectric materials into the TM-PSC design with a novel architecture in order to take advantage of the proven ability of ferroelectrics to enhance charge carrier separation in coupled semiconducting materials, reducing recombination losses. It will also draw novel photovoltaic effects in ferroelectrics, which, when coupled to TM-PSCs could reduce Voc losses and even lead to efficiencies beyond the Shockley-Queisser limit. Experimental data will be obtained to provide clear proof-of-concept for this novel approach by building, testing and measuring the novel device architectures. In parallel, a full commercial pathway will be planned by undertaking market research, cost-benefit calculations, patentability assessment and business planning. These will result in clear evidence and plans to drive forward
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A network to promote the effective andefficient use of fibre optic technology within Europe' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

In little over a decade, fibre-optic technology has revolutionised communications. Now the transmission of vast amounts of information by pulses of light travelling down glass threads about the size of a human hair is commonplace. Fibre-optic systems already form the backbone of a worldwide communications network and the use of fibres in local area networks is expandin g. However, despite the massive advances in the use of fibre-optics, the techno logy and its application within the industry are far from mature. Reliable measurement techniques and test methods supported by accurate measurement standards are essential for the practical and economic exploitation of optical fibres. This is the central theme of the network. The specification, measurement and test infrastructure for optical fibres used in telecommunication systems is already well developed. However as telecommunication systems become more advanced then specification standards become more stringent, and measurement and test procedures become more exacting. The w ork of the European Telecommunication Standards Institute in this field can be supported through collaborative research into new standards and through measurement intercomparisons. In applications beyond telecommunications, standards and the underpinning measurement and test infrastructure is poorly developed or, in many instances none existent. This lack of accepted standards and supporting measurement proce dures is impeding the efficient uptake of fibre optics in other industrial sectors. The proposed Thematic Network would bring together a broad spectrum of European Industry and other European organisations with an interest in the application of fibre optics; this would include fibre optic users and potential users, fibr e manufacturers, instrumen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Correlation Between Numerical Estimation of In Vivo Local Sphingosine-1-Phosphate Concentration and Endothelial Permeability' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Increased endothelial permeability allows accumulation of low-density lipoprotein (LDL) in the artery wall and may lead to atherosclerosis. The spatial heterogeneity of atherosclerosis has been thought to implicate flow mediated effects in the development of the disease. Indeed both in vitro and in vivo studies have shown a correlation between low or oscillating wall shear stress (WSS) and increases in atherogenic factors including increased endothelial permeability. However, the mouse, which has been used extensively as a model of atherosclerosis, has been shown to have high WSS in the aorta with little spatial variation.  And yet, the mouse exhibits strong spatial heterogeneity in atherosclerotic lesion development. Therefore factors other than WSS must play a significant role. There are a number of molecules with known effects on endothelial permeability and recently the sphingolipid, sphingosine-1-phosphate (S1P), has been shown to reduce permeability of endothelial cells in vitro. Platelets have long been known to have a protective effect on the endothelium and recently it was shown that S1P is the major barrier protector in platelets. Therefore it is hypothesized that: endothelial permeability correlates inversely with the combined local WSS and S1P concentration. This hypothesis will be tested by comparing measurements of endothelial permeability in the mouse aorta with estimates of the local S1P concentration and WSS as calculated using numerical blood flow modelling. The state-of-the-art imaging technique of ultrasound-particle image velocimetry will be used to measure the velocity in the aorta which will be the basis of the simulation. The latest methods will be used for modelling blood as a multiphase fluid, and convection-diffusion-reaction equations will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'multidisciplinary research cooperation on information suppression and diaspoRa communitiES as a target of fOreign iNformation mAnipulation aNd inTerference'.

assistant: **Objectives**

Foreign Information Manipulation and Interference (FIMI) including information suppression concern a series of threatening behaviours in the information domain and represents a major challenge, in terms of counteraction and the policy-making in this matter. Numerous FIMI operations carried out by non-EU State and non-State actors, often recorded within and beyond EU borders, aims to domestically threaten fundamental rights and freedoms and could as well produce threatening effects outside of their borders. The RESONANT project aims to create a better picture and understanding of State and non-State actors applying information suppression and to recommend strategies, tools and methodologies to reduce the impact and the vulnerability of the target groups, as the Diaspora Communities. In order to understand which actors outside the EU use in a coordinated manner Tactics, Techniques and Procedures (TTPS) of information suppression, RESONANT proposes to analyse information suppression incidents, thus creating an Evidence Base. Considering both the domestic and cross-border dimensions of information suppression, the project will also examine the mainly adopted TTPs, as well as the available Tools for their Detection and Analysis. For enhancing the knowledge regarding the effects of information suppression, RESONANT proposes an analysis of Behavioural changes in Diaspora Communities as result of information suppression and of the Awareness and Preparation of EU State Authorities in terms of practical legal means, providing selected Case Studies. Furthermore, the project will propose the definition of a Methodological Toolkit and Policy Recommendations, as well as the organisation of Table Top Exercises and Focus Group Policy Discussion, for addressing information suppression a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The Delta Opioid System and its Role in Pain Control and Drug Addiction'.

assistant: **Concept**

To search for novel compounds with selective agonist activity at d-opioid receptors by screening cDNA libraries from skin of several frog speciesTo develop mice deficient in d-opioid receptors using the 'knockout technique' and by treatment with antisense oligonucleotides directed to the d-opioid receptorTo assess the role of d-opioid receptors in pain and drug addiction by behavioural, neuroanatomical and biochemical studies in normal and d-opioid receptor deficient animals The cloning of the d-opioid receptor and the discovery of selective compounds which act at this site has provided the opportunity to study the role of this receptor in the regulation of brain function and to assess the potential therapeutic importance of new compounds acting at this receptor in the treatment of pain and in drug addiction. The primary objective of the proposed project is to determine the role of d-receptors in pain and in motivational and rewarding aspects of opioids which may be responsible for drug addiction. The work programme will involve the development of novel compounds which act at the d-receptor by screening of cDNA libraries from frog skin, an approach which has previously been successful in obtaining highly selective tools active at the d-receptor. Using these and other d-agonists and antagonists, which have recently become available, behavioural studies, brain imaging of receptor proteins and mRNA encoding for the d-receptor, plus microdialysis techniques will be used to study d-receptor mediated changes in neurotransmitter release. To further probe the role of d-receptors, mutant 'knockout mice', deficient in d-opioid receptors, will be developed and treatments with antisense oligonucleotides directed to the d-receptor plus chronic antagonist treatment during development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fabrication and development of nanotoxicology-test bacterial arrays for the investigation of antibiotics against multi drug-resistant bacteria' to be submitted under Seventh Framework.

assistant: **Abstract**

Bacterial resistance to antibiotics is one of medicine's most vexing challenges. Most antibiotics initially work really well, killing more than 99.9% of microbes they target. But through mutation and the selection pressure exerted by the antibiotic, a few inevitably manage to survive, and flourish as antibiotic-resistant strains. Hence, new strategies to design antibiotic to combat drug-resistant bacteria are required. Many drug delivery systems based on nanomaterials have been developed during the last decade, being the toxicology of these materials into single bacteria still not thoroughly evaluated due to the lack of reliable techniques to confine individual microbes. Prof. Whitesides' group in Harvard University (USA) is undoubtedly a world leader in this area, as it has a high international profile earned through many key contributions about novel nanofabrication methods for microbiological applications during the last 20 years. Prof. Miranda and Prof. Carrascosa (both from IMDEA Nanoscience-Spain) are the leaders of research groups working  in collaboration for (i) the development of novel antibiotic strategies based on drug delivery nano-systems and (ii) biophysical aspects of cell mechanics, self-assembly properties of organic heterostructures and supramolecular nanomachines. The time is ripe to integrate the various strategies developed by Prof. Whitesides’ group to confine single living bacteria with the novel strategies for drug delivery that are being developed at IMDEA Nanoscience-Spain.The aim of the present OIF includes consolidating IMDEA expertise in the toxicological effect of nanoparticle based drug carriers into individual bacteria in order to develop a novel set of antibiotics for treatment of multi drug-resistant bacteria and to contribute to funda