RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The molecular process and functional consequences of adaptation' to be submitted under Seventh Framework.

assistant: **Abstract**

Adaptation is the key concept in Evolutionary Biology. Understanding adaptation has important implications for basic and applied science since adaptation underlies processes such as the ability of species to survive in changing environments, resistance to antibiotics and cancer chemotherapies, and host-pathogen interactions. The recent increase in availability of whole genome sequences makes it possible to search for evidence of adaptation on an unprecedented scale. However, current approaches to the study of adaptation are often exclusively based on a priori candidate genes or on searching for signals of selection at the DNA level giving us a biased and incomplete picture of the adaptive process.The long-term goal of my research is to understand the molecular process of adaptation and its functional consequences. Towards this end, I will focus on the study of recent transposable element (TE)-induced adaptations in Drosophila melanogaster, which I have already shown to be common and readily detectable. I will apply a multidisciplinary approach in which I will combine genomics, population genetics, computational biology, molecular biology and experimental evolution. I will apply this integrative strategy to putatively adaptive mutations identified in populations from well-described contrasting climates, which will provide an ecological context to the identified mutations facilitating their functional characterization. Specifically, I will (i) identify putatively adaptive mutations in four nature-derived European populations with well-described contrasting climates; (ii) analyze their population genetics and evolutionary history; (iii) connect the adaptive mutations to changes in molecular function; and (iv) connect these changes to organismal phenotype and fitness. To ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Methods for Health Technology Assessment of Medical Devices: a European Perspective'.

assistant: **Objectives**

Health Technology Assessment (HTA) is widely accepted as a multidisciplinary approach studying the clinical, economic, social and ethical implications of development, diffusion and use of health technologies and its role in policy making is increasingly established in EU countries. However, the currently adopted methodological framework for HTA doesn’t fully encounter the challenges rising from intrinsic differences between different types of health technologies, and in particular medical devices. The general objective of MedtecHTA project is to investigate improvement of HTA methods to allow for more comprehensive evaluation of medical devices by acknowledging complexities rising from their integration into clinical practice.  The MedtecHTA project will provide more than 280 person- months of scientific research effort to: (i) explore current differences in methods used for HTA of medical devices in EU countries; (ii) investigate within- and between country variations in utilization of innovative medical devices (e.g implantable devices in cardiology) that have important implications on equity; iii) develop improved methods for satisfying three main pillars of HTA: comparative effectiveness, economic evaluation and organizational impact of medical devices and (iv) investigate uncertainty surrounding the development of new devices and investments in research. The essence of the MedtecHTA research methodology is a cross-disciplinary consortium with outstanding track record in health services research including health economics, healthcare management, health policy and also public health, epidemiology and clinical research. The MedtecHTA is expected to make a substantial contribution to the development of methodologies and practices of HTA for medical devices for a wide r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Amplifying ocean commons: pathways for scaling transformative governance' to be submitted under Horizon Europe.

assistant: **Abstract**

The ocean economy has exponentially expanded since the early 2000s, revealing how business-as-usual governance in the form of privatization and fragmented state strategies are insufficient for ensuring social justice and sustainability. Common property rights models – or commons - offer promising and transformative solutions for radically reforming ocean governance around shared rights, responsibilities and benefits to align stewardship and use. However, what remains unknown, is the viability, desirability and feasibility of commons as a scalable strategy. Answering these questions is urgent at all levels. Globally, the United Nations High Seas Treaty (adopted March 2023) mandates governing the high seas as a global commons, but with no clear governance pathways. Regionally, over 191 fragmented governance arrangements address transboundary issues but lack coordination and integration. Nationally, Blue Economy agendas are boosting growth without clear frameworks to deal with trade-offs, justice or sustainability. Locally, capacities are lacking for collective action, risk sharing and adaptation to climate and market changes.SharedSeas examines the viability, desirability and feasibility of using common property rights as a sustainable and scalable ocean governance model. It builds the conceptual and theoretical foundations of how a commons-based Blue Economy can realistically function and scale (WP1). Empirical social-ecological analysis will extract lessons, challenges and best practices across multi-level cases (WP2). Transdisciplinary participatory methods with diverse stakeholders will be developed to co-create future scenarios and pathways to address trade-offs (WP3). To scale impact, SharedSeas has the ambitious goal to theoretically develop and empirically test ei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Statistical Physics Approaches to Networks Across Disciplines' (NETADIS) targeting Seventh Framework.

assistant: **Abstract**

Networks are ubiquitous in all aspects of human existence. They manifest themselves in everyday life, they underpin the most advanced information and communication technologies, and they provide a powerful framework for addressing a wide spectrum of complex problems in the natural sciences, in engineering, and in economics and the social sciences. Networks, network-related science, and network-based technologies are thus of central importance to maintaining and improving human well-being as well as improving economic, technological, and scientific competitiveness.Statistical physics offers a powerful set of concepts and methods to analyze problems of exactly the type posed by today's key challenges in network science. While the European statistical physics community has an established tradition of coordinated cross-border research collaborations in this area, there has been so far no significant European coordination effort on the initial training side. The proposed ITN is set to fill that gap. Its aim is to train a cadre of future research leaders in advanced methods of analysis, inference, control and optimization of network structure and dynamics, thus maximizing the impact of statistical physics approaches across a broad range of application areas.The ITN will create an innovative training environment by exploiting synergies and complementarities of a research matrix defined by methods and themes on the one hand, and application foci on the other. It will be implemented by targeted secondments of early stage researchers across both axes of the research matrix. Existing local training provision and dedicated network-wide training events will be exploited to ensure that researchers are systematically exposed to the full range of statistical physics techniques and appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'BactiLine at-line system for automatic monitoring of microbial bacteria in water', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The growing population is putting a strain on the world’s water resources while at the same time the ever-developing industrialization is causing increasing occurences of water-contamination, both in potable water sources and in wastewater, which is discharged into rivers and oceans.To deal with these issues of water contamination, Mycometer has developed an automatic early-warning solution, the BactiLine at-line system, which promptly detects elevated levels of bacteria in water systems and sends out a warning when bacteria presence is above tolerated limits. BactiLine can be implemented at main control points in the distribution system, sample the water quality at pre-determined intervals and report to a control database.The BactiLine system is based on the existing and patented Bactiquant®-water method, which measures the total bacteria presence in a water sample by use of a sensitive fluorescence technologyFor end-users the BactiLine solution presents the following benefits: i.Faster response time, as water is sampled several times a day and bacteria counts are reported within minutes of the samplingii.Larger sample sizes, with bacteria concentrated through filtration, minimizes the risk of false positives.iii.Improved possibility for remote water quality monitoring through automated sampling from the water sourceiv.More resource-efficient sampling process with the elimination of manual work hours for lab technicianv.The assay sensitivity can be adjusted in real time, allowing the technology to be used in a broad range of water types and applicationsWith the BactiLine system, Mycometer will target utilities companies, wastewater treatment plants and industrial plants using large amounts of water for production processes, leading to a sales revenue of €7.2M, five yea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards development of new antibacterial strategy for dentistry' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ARGO project will be dedicated to explore innovative activities with focus on strong international, interdisciplinary and inter-sectoral cooperation in fields of chemistry, biomaterials, nanotechnology, microbiology, cell biology and dentistry. ARGO network will involve academic and industrial partners from EU MS and associated countries with the aim to open potential for innovative solutions in nanomaterials and clinical dentistry. The primary research goal of the project is to facilitate R&I activities with complementary competences of participant organizations for development of new antibacterial materials for dentistry, particular for the development a new antibacterial root-filling material.The project will be realized through the tight cooperation between partner organizations to create synergies for development and testing of innovative biomaterials for dentistry. The innovative technologies will be used to produce a root-filling material with nanoparticles with tailored biological and antibacterial properties. Evaluation of a new biomaterials with silver nanoparticles in vitro will be carried out on a specially designed tooth model. Biocompatibility and in-vivo assessment will be used to prove antibacterial effect of the new biomaterial on a relevant animal model. Interdisciplinary and inter-sectoral secondment will be the main tool for project realization with aim of strengthening research, training, communication and networking capacities of participant organizations and knowledge transfer from academia to industry and vice versa. Proposed research and training goals will lead to increased research, transferable skills and competences of early stage researcher with the aim to improve employability and career perspectives in both academic and industrial sectors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Morphodynamics in Plants: from gene to shape'.

assistant: **Innovation**

Morphodynamics is aimed at understanding how shape in plants is controlled during development, a major issue in developmental biology.. So far, research in the field has been mainly based on qualitative observations of mutants, with little considerations for the physics of the cells and tissues leaving many questions unanswered or unexplored. Here, using recent technological advances, to which the applicant has largely contributed, we propose an interdisciplinary and quantitative analysis of molecular and biophysical growth parameters from the cell to the organ level.Because the mechanical properties of the cell wall are generally accepted to control local growth rates and directions, their contribution to morphogenesis will be the central focus. How the molecular regulatory networks, including cell identity genes, influence cell wall synthesis and structure to induce local growth rates and directions is largely unknown at present, mainly because our knowledge lacks integration at different levels of complexity. In addition to the quantitative and interdisciplinary character of this proposal, an original aspect of the project will address the multi-scale nature of a growing tissue, establishing a causality link between local wall properties and multi-cellular outputs.To address this issue, we will combine cutting edge live imaging tools and micromechanical approaches with modelling frameworks recently developed in our laboratory. This will be performed using the developing flower in Arabidopsis, one of the best studied systems in biology and which has the strong advantage to grow without cell migration or rearrangement, vastly facilitating the dialog between the observations and the predictions from the models.In summary, using different interdisciplinary concepts and m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Decoding the Multi-facets of Cellular Identity from Single-cell Data'.

assistant: **Innovation**

Advances in technologies that measure gene expression at single-cell resolution have revolutionized our understanding of the heterogeneity, structure and dynamics of tissues and whole organisms in health and disease. Yet, in most single-cell experiments tissue structure, temporal trajectories, and their underlying mechanisms are lost or not directly accessible. Despite experimental advances, major gaps remain in understanding how tissues orchestrate multicellular functions. In recent years, we and others focused on computationally recovering single facets of single-cell data, such as tissue structure or differentiation trajectories. However, each cell encodes multiple layers of information about its type, location, and various biological processes. Disentangling these signals from large-scale, high-dimensional single-cell data is a major challenge. Building on my expertise in network reconstruction, probabilistic spatial inference and spectral analysis of single-cell data, I will take a unique approach to this challenge by developing computational methodologies combining machine learning and dynamical systems approaches to: (1) tease apart multiple cellular facets encoded in single-cell data; (2) infer interactions between these facets and mechanisms shaping spatiotemporal expression across them; (3) derive generative models to sample and predict unobserved cell states and design optimal perturbations, providing an interpretable platform to study conditions leading to a physiological disruption and therapies aimed at reversing it. My research program will tackle the core challenge in the single-cell era - transforming this exponentially growing, complex data into insight and principles for the underlying biology of multicellular systems. It will advance our understandin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Firm-to-Firm Trade Networks' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project analyzes the propagation of shocks through international trade. The microeconomic structure of trade networks is argued to favor the propagation and amplification of shocks with an end-effect on the dynamics and volatility of aggregate trade. The exploitation of highly disaggregated firm-to-firm trade data offers a unique opportunity to analyze these questions into details.The first part of the proposal studies the determinants of trade networks. I build a search-and-matching framework to explain the formation of bilateral trade relationships as a matching process between individual exporters in one country and individual buyers located in another country. This framework allows explaining the structure of trade networks observed in the data, both in the cross-section and over time. The model is also used to revisit several puzzles of the international economic literature, including the question of welfare gains from trade and the convergence to the law of one price. The second part of the proposal studies the consequences of the structure of trade networks for the volatility of trade and its resilience to relative price shocks. I study how the observed connections between individual firms help propagate individual and aggregate shocks, with an end-effect on the volatility of aggregate trade and the comovement of GDPs across countries. The high concentration of trade networks and the strength of production linkages, within and across countries, help amplify the aggregate effect of individual shocks. I also analyze how the structure of trade networks shapes the response of aggregate trade to relative price shocks. The nature and history of firm-to-firm relationships is argued to have implications for the aggregate elasticity of trade.


**Keywords:** Trade Ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ice Nucleating Particles in the Marine Atmosphere' in the context of a Horizon 2020 call.

assistant: **Objectives**

The formation of ice in clouds is fundamentally important to life on our planet since clouds play a key role in climate and the hydrological cycle. Despite the significance of ice formation, our quantitative understanding of sources, properties, mode of action and transport of Ice-Nucleating Particles (INP) is poor. In order to improve our representation of clouds in models we need to understand the ice-nucleating ability of all major aerosol types, including those from the world’s oceans.Despite oceans covering over 70% of the planet and sea spray being one of the dominant aerosol types in the atmosphere, its role in the formation of ice in clouds remains poorly understood. There are strong indications that biological organic components of sea spray can nucleate ice, but there is a lack of data to quantify it. In contrast, the ice-nucleating ability of major aerosol species from terrestrial sources, such as mineral dusts or bacteria, has received significant attention over the past few decades. A similar effort now needs to be made to understand marine INP. The key limitation to accurately representing INP in models over the world’s oceans is the lack of field data, a deficiency which I intend to address during this ERC fellowship.I propose to develop and deploy a new semi-autonomous INP instrument based on novel microfluidics technology which will cover the full range of mixed phase cloud conditions, unlike existing instruments. It will be housed in a unique highly instrumented mobile laboratory, which will allow us to access the remote oceans from atmospheric observatories and research ships. The data from these campaigns will be used to constrain the oceanic INP source and define the spatial and temporal distribution of marine INP in a state-of-the-art global aeroso