RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Lambda user controlled Infrastructure for European Research', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

A new generation of scientific applications is emerging that couples scientific instruments, data and high-end computing resources distributed in a global scale. Developed by collaborative, virtual communities, many of these applications have requirements such as determinism (guaranteed QoS), shared data spaces, large data transfers, that are often achievable only through dedicated optical bandwidth.High capacity optical networking can satisfy bandwidth and latency requirements, but software tools and frameworks for end-to-end, on-demand provisioning of network services need to be developed in coordination with other resources (CPU and storage) and need to span multiple administrative and network technology domains.In response to the above requirements, PHOSPHORUS will address some of the key technical challenges to enable on-demand e2e network services across multiple domains. The PHOSPHORUS network concept and test-bed will make applications aware of their complete Grid resources (computational and networking) environment and capabilities, and able to make dynamic, adaptive and optimized use of heterogeneous network infrastructures connecting various high-end resources.PHOSPHORUS will enhance and demonstrate solutions that facilitate vertical and horizontal communication among applications middleware, existing Network Resource Provisioning Systems, and the proposed Grid-GMPLS Control Plane. The PHOSPHORUS assessment will rely on experimental activities on a distributed test-bed interconnecting European and Worldwide optical infrastructures. Specifically, the test-bed will involve European NRENs and national test-beds, as well as GEANT2, Cross Border Dark Fibre Initiative and GLIF infrastructures. A set of highly demanding applications will be adapted to prove the conc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'RObotics Digital Innovation Network' (RODIN) targeting Horizon 2020.

assistant: **Abstract**

The overall aim of RODIN is to coordinate activities within the different PAA Innovation Actions and support them by increasing the efficiency and effectiveness of their activities, and improve their cross-PAA collaboration.Main objectives of the project are to:•Disseminate best practice in the operation of robotics DIH networks•Gather information from DIH networks on their composition, service offers, assets and infrastructure relevant to applying robotics in the PAA•Develop collaboration with and between the DIH networks, developing links to key stakeholders in robotics and technology•Deliver communication and outreach activities to external stakeholders and policy makers•Establish a resource to share information with DIH IAs•Assess the performance of DIH networks and provide feedback to the consortia to improve and enhance their operation•Coordinate access to, and development of, platforms, pilots and demonstrators•Enable industry-led standards development•Assess the access to finance for SMEs and the role DIH networks play in developing synergy between national, regional and European funding mechanisms•Develop means of extending the networks across Europe •Develop strategy around the future development of DIHs in robotics All objectives will be achieved by the proposed activities detailed in the work packages. RODIN also establishes and manages the Working Group that:•sets the basis for cooperation with the IAs•feeds back assessments of their performance and operation to the IAs•delivers best practice information to the IAs•develops models of sustainability for robotic DIH networksRODIN fully addresses the CSA called for under DT-ICT-02-2018 b): Robotics – Digital Innovation Hubs (DIH). It addresses the need to support and cooperate with the four Digital Innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An Integrated, Automated, Real-Time Tyre Management System for the Commercial Vehicle Sector.(TYRECHECK)' (TYRECHECK).

assistant: **Innovation**

During 2000 there were 41,083 road deaths across the EU; 185,000 persons were seriously injured and a further 1.56m persons were casualties. Of the 41,083 deaths, 8,217 (20%) can be attributed to, or were caused by, During 2000 there were 41,083 road deaths across the EU; 185,000 persons were seriously injured and a further 1.56m persons were casualties. Of the 41,083 deaths, 8,217 (20%) can be attributed to, or were caused by, commercial vehicles including, buses, trucks and vans, and of these, 1,297 (15.79%) can be attributed to tyre failure resulting from worn out tyres & low tyre pressures. 1n addition, over 360 million vehicle tyres enter the EU waste stream/annum representing a waste load of 2.5 mt of which 38% belonged to commercial vehicles. Research shows that the average life of a leased commercial vehicle tyre is 130,OOO km, but that this could be increased to 320,OOO km by proper tyre management with poor tyre management leading to 576 million litres of fuel wasted across the EU by commercial vehicles alone, producing an additional 1.55 mt of CO2 emissions. The European Commission's 2001 White Paper for 2010: time to decide¿ states the EU¿s commitment to reduce the number of road deaths within the EU by 50% by 2010, and the situation is worsening, 'Heavy goods traffic alone will increase by nearly 50% over its 1998 level'. The white paper also states 'strong economic growth in the candidate countries will also increase transport flows, particularly road haulage traffic' so the problem is worsening. The underlying cause of these problems is a lack of regular tyre management on all vehicles, with the current process reliant on manual tyre checking. Therefore, we propose to develop an integrated, automated, real-time tyre management system incorporating an auto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Signaling Networks of Ovarian Cancer Metastates, Stem Cells and Maturation Phenotypes'.

assistant: **Objectives**

Tumors are by definition both variable and highly adaptive, allowing them to grow beyond their original onset site and invade other organs, and in the process evading physiological intra and extracellular anti-tumor responses, and sometimes chemotherapy. This study proposes that ovarian cancers, and the heterogeneous cells that compose them, can be defined as a cell population(s) with an immature surface and signaling phenotype (with attendant self-replicative capacities) as well as a population(s) of cells with a more 'mature cell' phenotype. The expectation is that these two stages define a parent-daughter cell hierarchy and that this series of maturation events can be modeled akin to normal differentiation – with a set of pools of cells with a defined, stable phenotype linked to each other through transition state intermediates. Here, I apply a single cell systems biology approach to map signaling states at each stage of this proposed cancer-associated differentiation of ovarian cancer using perturbation mapping and high throughput systems biology approaches. The proposal will define the mechanistic underpinnings of ovarian cancer stem cells and the more mature phenotypes, the signaling states of cancer stem cells and daughter cells within patients that are resistant to cancer therapy, and finally a map that delineates the robustness profiles of the cancer-associated differentiation signaling networks and thereby optimal entry points for therapeutic interventions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Accessible Voice-Activated Technologies in a Voice-First World' (NUVOIC).

assistant: **Innovation**

The objective of this FTI project is to bring two unique and complementary commercial products to the market: “Nuvoic Home” and “Nuvoic Shop”. At the same time, the project will create commercial added value by inherently advancing Voiceitt’s novel core speech recognition technology for impaired speech. The strengthened speech technology in the new products will enable people with motor, cognitive and speech-related challengeThe objective of this FTI project is to bring two unique and complementary commercial products to the market: “Nuvoic Home” and “Nuvoic Shop”. At the same time, the project will create commercial added value by inherently advancing Voiceitt’s novel core speech recognition technology for impaired speech. The strengthened speech technology in the new products will enable people with motor, cognitive and speech-related challenges to access the benefits of mainstream voice-driven technologies, thus (we intend to demonstrate) improving independence and quality of life for these individuals. The consortium includes e-commerce giant, Procter & Gamble, that will leverage branding power, customer research and marketing methods to propel market uptake; the UK-based Karten Network and Belgium-based IMEC are highly recognised institutions that bring deep customer understanding and technical knowledge. The Nuvoic project will benefit people with speech and motor disabilities, and elderly with non-standard speech patterns, by providing the affected individuals an effective means to communicate with the people around them, as well as access to the benefits of mainstream voice-driven devices and technologies. It foresees product launches in 2022 and 2023 and presents a solid business opportunity on a product and sales level that will generate a turnover of €107Mill
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transitions in Rheology and Volatile Dynamics of Magmas: Mapping the Window to Explosive Volcanism' to be submitted under Horizon 2020.

assistant: **Abstract**

The growing number of inhabitants, tourists, and economic activities near volcanoes, require adequate volcanic hazard-assessment and -mitigation plans to guide decision-making in the case of volcanic unrest. Especially the Campi flegrei caldera (Naples, Italy) is a significant threat to the EU, as a large scale eruption is foreseen within the coming century. Accurate forecasting of volcanic behaviour is hampered by a lack of understanding of the magmas transport properties. Changes in viscosity due to the interaction between primitive and evolved magmas are documented to trigger volcanic eruptions across the globe. In the past decades, two key transition zones in magma rheology were identified that separate effusive from explosive and eruptible from non-eruptible magmas: 1) solidification through crystallization and 2) fluidization through vesiculation.Even though these transition zones are identified and the computation capacities to forecast volcanic eruptions have grown exponentially over the past decades, none of the available computer models are able to produce coherent results and no model scenario is verified in nature. This is because predictive approaches rely on accurate rheological data, which are absent to date.Recent technological advances, in combination with a new, interdisciplinary research approach now allow us to address this knowledge gap. Measuring the evolution of magma viscosity across the two change zones is one of the most interesting challenges at the interface between geo- and material-sciences. This project aims to develop a systematic understanding of the evolution of rheological transition zones from magma chambers to super eruptions. The results allow more precise forecasting of volcanic eruptions and may find application in the glass and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'DVD-readable opto-electrochemical Lab-on-a-Disc as small-factor wearable wireless medical device for obesity management'.

assistant: **Innovation**

Obesity is one of the most common and costly chronic disorder worldwide, and is a causal or a strong risk factor for several comorbidities, as type 2 diabetes (T2D), which is now reaching epidemic proportions. To monitor multifactorial disorders such as obesity and T2D, clinical evidences from more than one energetic biomarker are crucial. Current multiplexed systems present limited multiplicity capacities because they combine individual tests spatially separated from the others requiring complex and bulky instruments (e.g. HPLC), so they are difficult to operate out of the laboratory. Other described tests also cannot be adapted to monitor chronic disorders because they present at least one of the following critical limitations: (1) they are semi-quantitative (e.g. lateral flow test) so cannot perform the analyte monitoring to the required level of precision, (2) restricted to a single analyte which does not address the accepted criteria that an obesity management requires clinical evidence from multiple biomarkers and/or (3) cannot integrate the microfluidic processing required for blood analysis.To overcome current limitations, a novel multiplexed medical device is proposed here to enable for the very first time the fully control and management of chronic disorders as obesity and T2D. This will combine optics, electrochemistry, microfluidics and optoelectronics to monitor the most appropriate energy biomarkers (succinate as novel metabolite, in addition to lactate, ketones, pyruvate and glycaemia) in a friendly and decentralised way. No one has previously proposed a useful multiplexed approach as this, allowing the opportunity of the control of a particular energy biomarker such as succinate, which will facilitate current chronic disorders management. Thus, this nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Type 1 reyanodine receptor Structure and regulation by post-translational modifications and small molecules.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This proposal is aiming at understanding the structural basis of the type 1 ryanodine receptor (RyR1) regulation by post-translational modifications and by small molecules. RyR1 is present on the sarcoplasmic and endoplasmic reticuli of many mammalian cell types, most notably, in skeletal muscles. RyR channels are required for calcium release from intracellular stores, a process essential for excitation-contraction (EC) coupling in skeletal (RyR1) and cardiac (RyR2) muscles. They are amongst the largest ion channels, comprised of the four identical ~565 kDa channel-forming protomers. RyRs channel activity is regulated by post-translational modifications through multiple signaling pathways including adrenergic stimulation. We have obtained a 4.3 Å resolution cryo-electron microscopy (Cryo-EM) structure of RyR1 in the closed state and a 3.6 Å structure in an activated state. An atomic model was built, defining the transmembrane pore, placing all cytosolic domains as tertiary folds and unambiguously identifying small ligands including calcium, ATP, caffeine and the ryanodine in unprecedented details. In both data sets obtained, 3-D classification of particles revealed multiple distinct conformations providing a broad detailed picture of the dynamic process of RyR1 gating.  Here, I aim at improving and completing the atomic model of RyR1 and at determining the structural basis for RyR1 regulation by post-translational modifications and by small molecules. I will use X-ray crystallography to determine the high-resolution structure of the full length RyR1 as well as small fragments including the transmembrane pore and drug binding sites. Cryo–EM and 3-D classification will be used to identify structural changes induced by post-translational modifications and by native ligands
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ribonucleases for tumor therapy' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Foreseen ResultsIt must be stressed that among the innovative aspects of the proposed research is not only the production of an antitumor ribonuclease, but the production of a human antitumor ribonuclease agent. This will be obtained by conferring the therapeutic potential of well known non-human antitumor ribonucleases, such as the bovine and the amphibian enzymes mentioned above, to human ribonucleases devoid of antitumor action. A non-cytotoxic human ribonuclease is already available in one of the proposers' laboratory, and its cDNA has been cloned and expressed. Through mutagenesis and engineering of the DNA coding for this inactive human ribonuclease, recombinant mutant proteins will be obtained with the structural features essential for exerting an antitumor action. The production of the engineered proteins will be followed by the determination of their biological properties, and the mutants with the highest antitumor action will be analysed by NMR for the determination of their structures. This will in turn direct the programming of second generation mutants.DNA and protein engineering will be carried out by the proponent from Italy; the antitumor and biological assays will be performed by the proponent from the Czech Republic; the determinations of RNase mutant structures by NMR will be carried out by the Spanish proponent, while the Hungarian proponent will promote innovative NMR methodologies for the analysis of the dynamics of RNases.The success of the experimental approach we propose is very probable, as in the laboratory of one of the proponents has been already demonstrated that a biologically inactive ribonuclease can be transformed by directed mutagenesis in an antitumor ribonuclease. Furthermore, the work will be judiciously distributed among the differ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Light-matter interaction with terawatt and petawatt laser pulses'.

assistant: **Concept**

Positions are available this year at the Institute of Optics and Quantum Electronics (IOQ) in Jena/Germany for a doctoral research training. The IOQ belongs to the Friedrich-Schiller-University, it employs approximately 66physicists and technicians and is one of most important laser research centres in Europe. The graduate student studying for a doctorate will be trained in experimental Physics associated with ultra-intense laser-plasma interactions with matter. In addition the fellow will be trained in the design of ultra-intense compact solid-state laser amplifiers. The training will be supervised by Prof. Dr.R. Sauerbrey highly acknowledged in high power laser Physics who is assisted by experienced members of the Quantum-Electronics and X-Ray-Optics Group. The experiments will be carried out with the 15TW Titanium: Sapphire Laser system. A novel and compact Petawatt laser system is under development. Research will be undertaken in collaboration with several European University groups. The research will primary focus on the following topical areas:i) Development of a compact and diode laser pumped Petawatt laser system using Yb : glass as laser active material,ii) optimizing the performance of white light channeling in air by non-linear interaction with ultra-intense femtosecond light pulses. Study of the propagation, spectroscopic and application properties of the light pipes.iii)diagnosis of laser generated high-brilliance X-ray sources andiv) study of the yield and the dynamics of laser induced nuclear reactions. Doctoral training will happen in the stimulating atmosphere of a young, highly motivated and excellently supervised research team. Interested applicants with degree qualification in Physics who are currently studying for a doctorate in a similar area are e