RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Culture And RISkmanagement in Man-made And Natural Disasters' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

As risks are not “objective” but socially and culturally constructed, disaster management which is aware, respects, and makes use of local cultural aspects will be not only more effective but, at the same time, also improve the community’s disaster coping capacities. CARISMAND is setting out to identify these factors, to explore existing gaps and opportunities for improvement of disaster policies and procedures, and to develop a comprehensive toolkit which will allow professional as well as voluntary disaster managers to adopt culturally-aware everyday practices. This goal will be achieved by approaching the links, and gaps, between disaster management, culture and risk perception from the broadest possible multi-disciplinary perspective and, simultaneously, developing a feedback-loop between disaster management stakeholders and citizens to establish, test, and refine proposed solutions for culturally-informed best practices in disaster management. Whilst experts from a variety of fields (in particular legal, IT, cognitive science, anthropology, psychology, sociology) will undertake a comprehensive collation of existing knowledge and structures, a number of Citizen Summits and Stakeholder Assemblies will be organised. Systematically, CARISMAND will use an approach that examines natural, man-made and technical disasters, placing at the centre of attention specific aspects that affect culturally informed risk perceptions, eg whether disasters are caused intentionally or not, the different “visibility” of hazards, and various time scales of disasters such as slow/fast onset and short- and long-term effects. By organising six Citizen Summits (two per disaster category per year in two separate locations) where such disaster risks are prevalent , and three Stakeholder Assembl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissecting the cancer epigenome –  fundamental lessons from developmental biology' to be submitted under Horizon Europe.

assistant: **Abstract**

DNA methylation is a tightly controlled mechanism that is essential for normal development and genome regulation. Although maintained in a highly static pattern across healthy tissues, DNA methylation is globally reprogrammed in nearly all malignant cancers, including gains at thousands of gene promoters and global loss across large domains. Substantial work from our group to characterize multiple primary tumor cohorts, transgenic animal models, and cancer cell lines finds that current experimental systems rarely, if ever, capture key features of the cancer epigenome. In contrast, our parallel efforts to understand epigenetic dynamics in development suggest an alternative, highly innovative hypothesis with a clear path for investigation. We find that the epigenetic alterations in cancer very closely mirror patterns that emerge in the early placenta, a tissue that naturally acquires invasive, immune suppressive, angiogenic, metabolically plastic and mutationally tolerant properties. Notably, this cancer-like epigenome depends on dynamic, previously undiscovered configurations of regulators that can be triggered without genetic mutation. With these insights, we have innovated tractable in vitro and in vivo platforms to dissect the biochemical, genetic, and physiological properties of this unique form of genome regulation as it supports developmental processes. We believe these efforts will demonstrate that the placenta and by extrapolation the cancer epigenome reflect a switch-like reprogramming event that can be studied at high resolution. In line with the ERC-ADG program’s goals, we will pursue ambitious and critical questions, resolve long-standing paradoxes and provide a complete model of epigenetic transformation in development with direct disease implications. Our w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The multisensory dimension of memory, from single neuron to neural network. A multiscale electrophysiological approach to reveal the mechanism of face-voice association for person identity recognition' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Long-term memory is intrinsically multisensory: after learning, the various sensory inputs related to an event are associated into an abstract representation. Multimodal representations present clear behavioural benefits for adaptation, like facilitating recognition. Nonetheless, while multisensory integration and memory are profoundly nested brain processes, little is known about the neural basis of their reciprocal influence. Is remembering multimodal, by nature? Do multisensory representations influence sensory processes? In the present project, I will elucidate these queries from a neurophysiological standpoint using a unique multiscale approach in human subjects: from the single cell to the brain network level. Specifically, I will combine the use of a micro-meso electrode prototype with surface EEG to characterize underlying neuronal oscillatory mechanisms and macroscopic aftermaths. Lastly, to direct our research I will utilize a key medium for social interaction: face-voice association, core of person identification.This multidisciplinary and innovative project will be carried out at the CerCo laboratory (CNRS, France), where a pioneer platform for intracranial recording inhuman has recently been developed. I will transfer to the host institution my expertise in advanced LFP analysis and precise three-dimensional electrode localization. Conversely, I will learn single-cell techniques, the state-of-the-art from experts in human memory and participate in oral communication trainings. Furthermore, my project action will adhere to a knowledge dissemination plan, from the scientific community for results communication to broader public audiences in order to illustrate research assets to the community. Ultimately, this research program will be a stepping-stone toward
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Zinc Interaction with Phosphorus in Root Uptake' (ZIPRU), addressing dissemination and exploitation.

assistant: **Impact**

The overall goal of this project is to understand phosphorus (P) and zinc (Zn) interactions in the mineral nutrition of Brassica oleracea, a species that has been bred into a wide range of crops such as broccoli, cabbage, kale and cauliflower. To achieve this, we will develop a comprehensive understanding of key mechanisms and coordination of P-Zn cross-talk that allows high P-use-efficiency (PUE) plus high Zn accumulation and thereby provide the basis for breeding programmes combining improved PUE and increased shoot Zn concentrations. Selected B. oleracea genotypes with extreme PUE and shoot Zn concentrations identified recently by the host lab and collaborators will be studied stepwise using a multidisciplinary approach including state of the art methods. Firstly, the genotypes will be characterised phenotypically, specifically for yield, root architecture traits and bulk mineral element concentrations. Secondly, root exudates will be characterised biochemically initially using Fourier Transformation Infrared for general overview followed by Liquid Chromatography-Mass Spectrometer for detailed analysis. Thirdly, tissue-specific localization of mineral elements, specifically P and Zn, will be determined using multielemental and quantitative imaging technique micro-Proton-Induced X-Ray Emission. Fourthly, gene expression profiles will be studied using the Brassica Exon Array. The anticipated results will be used to promote sustainable agriculture, through a reduction in fertiliser inputs and to improve dietary mineral intakes by increasing the mineral content of edible crops. Breeding varieties with greater PUE, without having a significant negative impact on shoot Zn content, is one strategy to simultaneously reduce the use of P fertilizers and combat dietary Zn defic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Effect of Manifestations of Religion in the Public Space on Sociopolitical Integration of Minority-Religion Immigrants' in the context of a Horizon 2020 call.

assistant: **Objectives**

Recent globalization and immigration trends are motivating tremendous efforts to regulate manifestations of minority religions in the public space, such as religious structures, stores, attire, and rituals (hereafter, spatial religious manifestations). Yet the empirical literature has, to date, not taken on the methodologically and conceptually challenging undertaking of theorizing, operationalizing, and assessing this dimension of religion. In particular, it remains unclear what causal effect manifestations of religion in the public space have on minority-religion immigrants’ sociopolitical integration: do they, by validating immigrants’ identity, facilitate a sense of belonging and the endorsement of local practices, or nurture alienation and hostility toward the host society?Integrating up-to-date theories and methods from political science, psychology, sociology, and geography, and optimizing external and internal validity, this project is the first large-scale research to examine the causal effect of exposure to spatial religious cues on sociopolitical integration, studying minority-religion immigrants of the three monotheistic religions in four urban settings.The research will be divided into three work packages: (1) conceptualization and operationalization of spatial religious manifestations; (2) comparative naturalistic and survey-embedded experiments examining the effect of real-world spatial religious cues on minority-religion immigrants’ sociopolitical integration; and (3) a panel survey with longitudinal geocoded data analyzing the conditions in which spatial religious cues are particularly instrumental in local-level integration.Besides developing a novel approach to the study of religion in politics, this project will open new horizons in the understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'IMPlementing geriatric assessment for dose Optimization of CDK 4/6-inhibitors in older bReasT cAncer patieNTs' to be submitted under Horizon Europe.

assistant: **Abstract**

Current evidence from both randomized trials and real-world evidence studies suggests that older breast cancer patients derive clinical benefit from the addition of CDK 4/6-inhibitors to endocrine therapy but with higher risk for adverse events and treatment discontinuation compared to younger patients. The IMPORTANT project will design and conduct a pragmatic clinical study with a decentralised approach for older patients with advanced breast cancer aiming at high level of evidence (level I) with multi-layer results that can enable changes in current clinical practice. This study will be conducted across 6 (six) EU countries, and will include more than 500 female and male patients. The project will also perform a series of analyses over a) a wide range of clinical-relevant primary and secondary endpoints targeting to contribute to current clinical practice and b) the implementation of specific strategies aiming at more individualized treatment and follow-up approaches to a clinical trial setting that highly resembles real-world setting due to the trial's pragmatic design.The project will be developed in 60 months by a competitive consortium of 19 partners from 11 countries, which corresponds to a well-balanced structure, involving clinical sites, SMEs, universities and patient advocacy organizations. Despite the great diversity of entities within the proposal, IMPORTANT partners bring state-of-the-art complementary skills ensuring the ability of the consortium to successfully complete the proposed work.This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment’.


**Keywords:** geriatric oncology, breast cancer, male breast cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Study the functions of the hepatic sympathetic nerve and the receptor Adrb3 in liver-mediated adaptive thermogenesis.' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Core body temperature is among the best-guarded constants in homeothermic species. It results from the evolution of physiological mechanisms capable of regulating the production as well as the exchange of heat with the environment. The objective of my proposal is to define a new role for the liver in adaptive thermogenesis whereby the liver will be involved in heat production under the regulation of the hepatic sympathetic nerve. I will first ascertain that the liver can generate extra heat when adaptive thermogenesis is triggered (Aim 1). Hepatic adaptive thermogenesis will be demonstrated using a combination of interdisciplinary, cutting-edge technologies normally applied to the fields of physics and chemistry. I will then determine the molecular foundation of this hepatic heat production (Aim 2). For this purpose, OMICs data (transcriptomic, proteomic and metabolomics) will be generated from cold-exposed liver tissues in order to identify: (1) the hepatic molecular heating mechanism; (2) the expected metabolic rewiring necessary to sustain prolonged heat production from thermogenic hepatocytes.  Finally, I will study how hepatic adaptive thermogenesis is regulated by the hepatic sympathetic nerve at the anatomical level and by the adrenergic receptor Adrb3 at the molecular level (Aim 3). For this purpose, I will use a combination of surgical (hepatic sympathectomy) and genetic (generation of liver-specific beta-adrenergic receptor 3 knockout mice) ablation techniques. Longstanding observations, together with my own preliminary results argue for this existence of hepatic adaptive thermogenesis and its molecular characterization would certainly represent a major breakthrough for both our fundamental understanding of homoeothermic physiology as well as for future clinic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Robust control of combustion engines'.

assistant: **Objectives**

There has been much recent progress in methodologies for the design of controllers such that the feedback behaviour is robust to changes in the system being controlled. In order to meet new emissions legislation in petrol and diesel engines, more effect transient control will be required (rather than just steady state calibration). The proposed project is in collaboration with Ford, UK, where much of the modelling and experimental work will be carried out. The project will first derive a phenomenological model of an IC engine and estimate parameters from experimental data. Then a model of the uncertainty will be examined and robust control methods investigated. The final objectives will be to implement and assess such a controller.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Multi-scale Composite Material Selection Platform with a Seamless Integration of Material Models and Multidisciplinary Design Framework.'.

assistant: **Objectives**

The mission of COMPOSELECTOR is to develop a Business Decision Support System (BDSS), which integrates materials modelling, business tools and databases into a single workflow to support the complex decision process involved in the selection and design of polymer-matrix composites (PMCs). This will be achieved by means of an open integration platform which enables interoperability and information management of materials models and data and connects a rich materials modelling layer with industry standard business process models. In order to satisfy the need for effectively designing and producing increasingly sophisticated materials, components and systems with advanced performance on a competitive time scale there is a particular need in industry for chemistry/physics-based materials models and modelling workflows which capture the performance of materials, accounting for material internal microstructure and effects of processing, provide accuracy/validation of predicted data, and relevant management of uncertainty and assemble knowledge ready for decision makers to act upon. COMPOSELECTOR will address these needs by integration of  (discrete and continuum) materials models and process models as well as structured and unstructured data into a standards-based, open integration framework, implementing uncertainty management and multi-criteria optimisation in order to provide actionable choices, and  building tailored knowledge apps to support decision makers. The human interface of COMPOSELECTOR will be supported by Visual Analytics capable of integrating qualitative, quantitative and cognitive aspects for a user-friendly management of the vast quantity of available data. The COMPOSELECTOR BDSS will be applied to and validated by end users targeting accurate, reliable, ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HIGH PERFORMANCES PREDICTION, DETECTION AND MONITORING PLATFORM FOR PATIENT SAFETY RISK MANAGEMENT' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

According to recent studies, Risks Against Patient Safety (RAPS) represent one of the most important  factors of dead in hospitals: during therapy, more then 8% of patients recovered in hospitals suffer for additional disease that in almost 50% of the cases produce either dead or significant additional health problems. RAPS occur in any stage of the patient care process.REMINE project idea originates from the common difficulty in conducting a analysis, early identification and effective prevention on RAP when there are significant mass of inhomogeneous data sources, stored in multimedia databases, and a distributed environments with different care professionals contemporary involved.To contrast the RAPS trends and the malpractices diffusion, REMINE prosecutes a number of main objectives. a new technological platform, new care process organizational requirements. Main elements are: mining of multimedia data; modeling, prediction, detection of RAPS, RAPS management support system and info broker patient safety framework.Main outcomes of REMINE will be: time reduction in collecting data, time reduction in RAPS analysis, standardization of common language, evolution in the interaction model, reference framework, patient safety improvement, health care cost saving (within an estimated RAPS reduction between 6% to 9% of RAPS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Beyond 5G – OPtical nEtwork coNtinuum' in the context of a Horizon 2020 call.

assistant: **Objectives**

B5G-OPEN targets the design, prototyping and demonstration of a novel end-to-end integrated packet-optical transport architecture based on MultiBand (MB) optical transmission and switching networks. MB expands the available capacity of optical fibres, by enabling transmission within S, E, and O bands, in addition to commercial C and/or C+L bands, which translates into a potential 10x capacity increase and low-latency for services beyond 5G. To realize multiband networks, technology advances are required, both in data, control and management planes. Concerning devices, these include new amplifiers, filterless subsystems, add/drop multiplexers, etc. Such technology advances complement novel packet-optical white boxes using flexible sliceable Bandwidth Variable Transceivers and novel pluggable optics. The availability of MB transmission will also lead to a complete redesign of the end-to-end architecture, removing boundaries between network domains and reducing electronic intermediate terminations. The control plane will be extended to support multiband elements and a ‘domain-less’ network architecture. It will rely on physical layer abstraction, new impairment modelling, and pervasive telemetry data collection to feed AI/ML algorithms that will lead to a Zero-Touch networking paradigm including a full featured node operating system for packet-optical whiteboxes. The results will be shown in two final demonstrations exposing the project benefits from operator and user perspectives. B5G-OPEN will have a clear impact on the society showing the evolution towards a world with increased needs of connectivity and higher capacity in support of new B5G services and new traffic patterns. The consortium includes partners from 8 countries: three major telecom operators, three vendors