RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strengthening rural livelihoods and resilience to climate change in Africa: innovative agroforestry integrating people, trees, crops and livestock' (GALILEO).

assistant: **Concept**

The overall objective of GALILEO is to rely on genuine Multi-Actor Approaches (MAA) to co-develop context-specific, people-centered agroforestry innovations in representative agro-pastoral, agroforestry, and agro-silvo-pastoral systems from Sub-Saharan Africa (SSA). The aim is to promote agroforestry as leverage to significantly improve agricultural, household, and climate change adaptation and mitigation performances and to enhance biodiversity in SSA.    We build upon 8 agroforestry Living Labs (LLs: local scale and actors), 4 national and 1 regional Innovation Platforms (IPs), set up across 4 AU SSA countries. Our LLs are set in semi-arid zones of Senegal and Kenya and normally humid but drought-prone zones of Ghana and Cameroon thus comparing and covering a large range of SSA conditions.    Through MMA, we co-construct potentially adoptable scenarios ex-ante with Innovator, Target, and Control actors in our LLs, then implement, assess, and compare performances in their pilot plots during the whole project. We use field observations also to calibrate process models, able to simulate under future CC scenarios. After full multi-criteria and trade-off analysis, we finally co-select the most effective scenarios ex-post. We thus rely on transdisciplinary research, providing qualitative and quantitative data on the biophysical, socio-economic, and environmental performances.    Such adoptable agroforestry innovations will also enable farmers/pastoralists and stakeholders to diversify their incomes from new agroforestry value chains, of which 2 are GALILEO-original. They will also benefit from carbon farming and payment for ecosystem services opportunities.    Through our IPs, we also engage in solid MAA collaborations and policy dialogues to first identify bottlenecks and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing positive and destructive leadership on multiple dimensions: How to better understand and improve the behaviour of the people who lead us.' in the context of a Horizon 2020 call.

assistant: **Objectives**

Leadership is a key factor for success, coherence, and progress in a multitude of compelling contexts. Not only the corporate world, the military, and politics rely on skilful leadership to bundle their potential, unite followers and members, and distil the various centrifugal forces within organisations into success. European societies currently face a climate of insecurity due to various socio-political events and, thus, perceived threat amongst citizens. Such environments have been shown to especially call for strong leadership which ensures stability and safety. However, we currently see multiple expressions of destructive leadership - i.e. a process in which the activities, experiences and/or relationships of an individual are repeatedly influenced by their supervisor in a way that is perceived as hostile and/or obstructive - around the globe, which endanger peaceful and diplomatic solutions and, thus, the success and well-being of society.Destructive, forms of leadership have barely been studied empirically, although it is known to lead to harmful behaviour, including impulsivity and aggression. Destructive leadership behaviour causes severe adverse effects amongst followers and, subsequently, hampers organisational success. It is of utmost importance to advance the theoretical understanding as well as the practical reduction of destructive leadership. To achieve this, we need to i) asses it comprehensively, ii) correctly identify sub-types, and iii) develop personalised interventions which enhance leaders’ self-reflection skills and behaviour.The proposed project will complete all three steps in the context of Executive Education. It will develop multi-dimensional assessment of destructive leadership (including self-report, follower-report, cognitive, behavioural
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Place for the Asylum Seekers. European migration policies and their socio-spatial impacts' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the past two years the European Union has seen an enormous influx of migration. More than 1 million people arrived by boats in 2015 and more than 230,000 people in the first six months of 2016.PASS aims to assess the complicated field of discourses and practices of regulating migration flows into the EU, focusing on its socio-spatial impact since 2013, when the last Dublin II Regulation was promulgated (No. 604/2013). On the one hand, the project analyses the very complex stratification of geographical spaces and procedures shaped by the EU and by different national legislation. On the other hand, the research also explores the interaction between the policies and procedures plan and experiences of migrants themselves, often characterized by tensions, resistance and clashes.After a preliminary analysis of EU immigration and asylum law, the project examines the cases of Italy and of the Netherlands. Italy is one of the countries which has seen the highest number of migrants arriving and from where 39,600 asylum applicants are to be relocated under the two EU Council Decisions on relocation to other Member States under a quota system. In the period between 2015 and 2017 about 2.150 refugees are to be relocated from Italy to the Netherlands  (European Commission, COM(2016) 165). The project uses a dual perspective: 1. A top-down perspective, involved in the analysis of the European, Italian and Dutch immigration policies; 2. A bottom-up perspective, embedded in the migration experience and focused on the migrants' agentivity. The final goal of PASS is to elaborate empirical data in order to build more human rights oriented policies. PASS intends also to provide an appropriate political response to the needs expressed by the migrants and to combat misconceptions about th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Investigating the role of the intercrypt goblet cells in inflammatory bowel diseases.' (GAP).

assistant: **Innovation**

The mucus layer produced by the goblet cells (GCs), provides the barrier between the microbiota and the intestine preventing the occurrence of the inflammation process. Indeed, alteration in microbiota towards mucus degrading bacteria, are often associated with impaired mucus barrier properties and inflammatory bowel diseases, such as ulcerative colitis (UC). Although, the exact mechanisms behind UC are not understood, defects in luminal compartmentalisation of bacteria by mucus could play a major role in this disease etiology. The recent identification of the intercrypt goblet cells (icGCs) population has improved the understanding and modified the model of the mucus layer formed on the epithelial surface. The icGCs secrete mucus that differs from mucus produced by crypt-residing GCs, and both are required to provide a protective mucus barrier function. Deficient intercrypt mucus secretion or reduced icGC numbers leads to disruption of the mucus layer with an impaired organization at the mucus surface which correlates with increased colitis susceptibility. However, the mechanisms behind icGC defects still remain unclear. In this project, I will combine both animal and human studies to decipher the molecular mechanisms behind the loss of icGCs that occurs during UC and elucidate to what extent a deviated microbiota is involved in their modulation. The data from the research programme will underpin the development of future therapeutic strategies to improve human health. The fellow has experience in microbiota research, metabolism and nutrition. With this fellowship, he will have the opportunity to develop skills in mucin biology, evaluation of the mucus properties and imaging experiments. This grant will enable the fellow to develop his current skill set to include meth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Decoding calcium pathway activated by plant intracellular immune receptors'.

assistant: **Concept**

Plant diseases have been causing global issues to agriculture, economy, and humanity. Understanding how plant disease resistance works is vital to finding durable and sustainable solutions to protect our crops. One key molecular hallmark of plant immune activation is mediated by calcium signalling, which is a commonly shared and well-known second messenger in all cellular organisms. However, it has been overlooked how calcium signalling is activated by plant intracellular nucleotide-binding and leucine-rich repeat immune receptors (NLRs), which are often one of the main genetic resources of plant breeding for disease resistance. In addition, upon activation, it is not known how the immune receptors activate a large scale of defence genes via calcium signalling. To answer these questions, I will be addressing three objectives: 1) Decoding compartmentalized calcium dynamics activated by intracellular immune receptors (NLRs); 2) Characterizing the role of helper NLRs in producing calcium signatures and transcriptional reprogramming; 3) Identifying calmodulins (calcium-binding proteins) that interact with key transcription factors to decode the calcium signature during effector-triggered immunity mediated by NLRs. I will use an interdisciplinary approach combining cell biology, genetics, and multi-omics. The outcome of this study will expand our understanding of plant immunity and provide novel insights for crop breeding specifically tailored to counter hazardous pathogens. I aim to 1) broaden my expertise in plant signalling research; 2) expand my toolbox of cellular biology and genetics; 3) develop the leadership skills required for managing a research group. Furthermore, I will strengthen my scientific track record and network. This DeCaETI project will be performed at t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structure and function of SMAT: a putative cellular decision-maker for transcription factor assembly' (SMAT) under Seventh Framework.

assistant: **Objectives**

Transcription factor IID (TFIID) is a key player in regulated transcription of eukaryotic genes by RNA polymerase II. The scaffold of TFIID is composed of a number of TATA-box binding protein-associated factors (TAFs), which are also found in other multimeric transcription factors (e.g. SAGA). An elaborate system of decision-making therefore must occur that directs the assembly of TAFs into either TFIID or SAGA or other TAF containing complexes. Recently, a multimeric 400 kDa small TAF-containing complex, SMAT, was discovered. SMAT is proposed to be a potent regulator of committed TFIID and SAGA assembly. The objective of this proposal is to elucidate the role of SMAT in eukaryotic gene regulation by means of an integrated, interdisciplinary approach combining structural, biochemical and in vivo cell biology methods. SMAT and its subcomplexes will be produced recombinantly by state-of-the-art eukaryotic expression techniques. Stable variants of SMAT core-complexes will be identified by a novel limited proteolysis/mass spectrometric approach and translated into expression experiments by utilizing an automated cloning platform technology. Intensive screening for growth of single, well diffracting crystals will be performed at the high-throughput crystallization facility at EMBL. By combining synchrotron X-ray crystallography, electron microscopy and small angle X-ray scattering experiments, a molecular model of SMAT will be obtained. Based on this model, point mutations will be designed, which specifically destabilize SMAT. Effects of the mutant proteins and of posttranslational modifications on the cellular decision-making process of TFIID or SAGA assembly, as well as SMAT integrity, will be assessed by in vivo functional assays in HeLa cells. The interdisciplinary natur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Targeting intracelular RANKL in breast cancer'.

assistant: **Innovation**

Breast cancer is the most common malignancy among females in the western world, resulting in half a million deaths annually, mainly due to metastatic disease. Triple negative breast cancer (TNBC) accounts for 1520% of all breast cancers (300.000 women diagnosed worldwide per year). Despite novel treatments, TNBC remains a clinical challenge due to high rate of relapse, a propensity to form visceral metastasis and its heterogeneity. There is an urgent need to identify novel targeted therapies and associated biomarkers for the treatment of the TNBC. IntraRANKL is based on the generation of innovative drugs targeting RANKL  for the treatment of TNBC, with a different mechanism of action than denosumab, the gold standard treatment against RANKL.Small molecule inhibitors generated in IntraRANKL could plausibly be positioned as a novel targeted therapy for TNBC. The main benefits of IntraRANKL are based on the unmet need to improve the treatment of TNBC patients, and the economic burden for public health systems generated by standard non-selected and ineffective cancer treatments. Although our drugs are aimed for TNBC, they can benefit other breast cancer subtypes and tumors expressing RANKL. Moreover, if drugs against RANKL prove to be efficient, they could also clinically benefit patients suffering bone metastasis that are currently treated with denosumab and bisphosphonates. Analyses of RANKL will allow to stratify patients that might benefit from IntraRANKL inhibitors, improving the existing treatments for skeletal-related events and reducing the main complications associated with lifealtering morbidity affecting several types of prevalent cancers.


**Keywords:** Intracellular RANKL, Triple negative breast cancer, RANK signaling pathways, small molecules
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Developing and improving consumer-supplier relationship in traditional commerce using information and communication technologies'.

assistant: **Objectives**

This project falls within the Information Society Technologies and is a research and development activity in Action Line II.3.3 Enhanced consumer-supplier relationships".The retail trade is a vital element of the European economy. It comprises more than 4 million enterprises, with a turnover of more than 2BEuro and a workforce of approximately 15 millions of persons. The most important sub-sector within retailing trade is Food & Drinks, which accounts for 43% of the total.In this context, the strategic goal of DISTRICT is developing a set of tools and the associated business model that enable small food retailers to remain competitive in the e-commerce era, whilst keeping their distinctive marketing values. These unique competitive advantages are, for example, personalised attention and advise to the customer, high quality fresh products.DISTRICT tool set includes innovative features such as user profiling, demand management, together with an integrated web based business management system. It will be installed and evaluated in two European pilots in the food retailer sector.Objectives:This project falls within the Information Society Technologies and is a research and development activity in Action Line II.3.3 "Enhanced consumer-supplier relationships". The retail trade is a vital element of the European economy. It comprises more than 4 million enterprises, with a turnover of more than 2 BEuro and a workforce of approximately 15 millions of persons. The most important sub-sector within retailing trade is Food & Drinks, which accounts for 43% of the total. In this context, the strategic goal of DISTRICT is developing a set of tools and the associated business model that enable small food retailers to remain competitive in the e-commerce era, whilst keeping their distin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Low Emission Systems Simulation Procedures for the Development of Fuel-Efficient Combustor Technology'.

assistant: **Concept**

In this project, the combustion conditions in future aero engines were predicted, the pollution levels on the basis of todays technology were assessed and fundamental processes of pollutant formation were investigated. Finally, 3 promising combustion concepts were identified for application in advanced aero engines although they differ in nitrogen oxide reduction potential, development effort and in technological risk involved. In order to assess the likely emissions from future aircraft gas turbines, a database was established containing information on the combustor inlet conditions for 6 different engine categories. To predict the future nitrogen oxide levels which would be generated by current combustor technology at these future conditions, empirical correlations were applied using the input from the combustor inlet conditions database. Based on the combustor entry conditions for future engines, various pollution reduction methods were selected and critically analyzed. A coordinated series of experimental and theoretical studies was carried out to investigate fundamental aspects of combustion.This involved studies of:fuel atomisation;capabilities of laser diagnostics;influence of primary zone geometry and stoichiometry;influence of primary zone homogeneity;smoke production in rich burning primary zones;optimisation of a small engine premix duct.3 different promising combustion concepts were identified:the double annular combustor (DAC);the lean premixed and prevaporized combustor (LPP);the rich burn, quick quench and lean burn combustor (RQL). The lowest nitrogen oxide reduction potential was identified with the lean combustion method without premixing in a staged combustor design (DAC). The LLP concept is expected to reduce nitrogen oxide by more than 75%. The majo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Strange Mirrors, Unsuspected Lessons: Leading Europe to a new way of sharing the world experiences' (ALICE).

assistant: **Innovation**

Europe sits uncomfortably on the idea that there are no political and cultural alternatives credible enough to respond to the current uneasiness or malaise caused by both a world that is more and more non-European and a Europe that increasingly questions what is European about itself. This project will develop a new grounded theoretical paradigm for contemporary Europe based on two key ideas: the understanding of the world by far exceeds the European understanding of the world; social, political and institutional transformation in Europe may benefit from innovations taking place in regions and countries with which Europe is increasingly interdependent. I will pursue this objective focusing on four main interconnected topics: democratizing democracy, intercultural constitutionalism, the other economy, human rights (right to health in particular).In a sense that the European challenges are unique but, in one way or another, are being experienced in different corners of the world. The novelty resides in bringing new ideas and experiences into the European conversation, show their relevance to our current uncertainties and aspirations and thereby contribute to face them with new intellectual and political resources. The usefulness and relevance of non-European conceptions and experiences un-thinking the conventional knowledge through two epistemological devices I have developed: the ecology of knowledges and intercultural translation. By resorting to them I will show that there are alternatives but they cannot be made credible and powerful if we go on relying on the modes of theoretical and political thinking that have dominated so far. In other words, the claim put forward by and worked through this project is that in Europe we don’t need alternatives but rather an alterna