RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Three dimensional sediment transport measurements by acoustics' (TRIDISMA).

assistant: **Innovation**

The primary objective of TRIDISMA is to develop, test and evaluate a prototype instrument to measure sediment transport close to the sea bed. The new instrument will simultaneous measure profiles of the suspended sediment concentration, sediment size and the three components of the fluid velocity, with high temporal (1-10 Hz) and spatial (<1 cm) resolution. The range of operation will be of the order of one metre but a secondary objective will be to extend the capabilities of the instrument to operate very close to the bed, within 10 cm, and to examine problems involved in measuring bed load. To minimise disturbance of the systems under investigation, high-frequency acoustics will be used throughout, although ancillary instrumentation will be used in the instrument evaluation and calibration, and for the bed load transport measurements. Engineers, Port and Harbour Authorities, Dredging companies, Fisheries and Pollution scientists, as well as coastal oceanographers and geomorphologists, desperately need an accurate instrument to measure sediment transport in coastal and estuarine waters. Most existing instruments for use in the marine environment measure either flow (in one or more directions) or suspended sediment concentration, by optical or acoustic transmittance or backscatter. None is able to rapidly profile the concentration, size and the three-dimensions of flow, necessary for a realistic measurement of transport, particularly close to the sea bed where much of the sediment transport can occur. TRIDISMA will develop and test a prototype instrument, based on non-intrusive acoustic methods, which will be used to evaluate the basic technologies associated with Coherent Doppler and Correlation techniques. Results from TRIDISMA will provide a specification which can b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Early Diagnosis of Prostate Cancer and Preparation of a certified Prostate Specific Antigen Reference Material' (1994-1998).

assistant: **Innovation**

(1) Clinical study. Prostatic cancer is the second cause of death due to cancer in men. Progression of the early stage is relatively slow, providing a reasonable time wherein the disease can be cured. However, in spite of the availability of three updated tools, i.e. PSA (prostatic specific antigen) level measurements, digital rectal examination (DRE) and transrectal ultrasonography (TRUS), prostatic cancer is still diagnosed too late.(2) Certified PSA Reference Material. PSA is one of the most promising tumor markers. Its merits (sensitivity, specificity and cost-effectiveness in diagnosing early stage prostate cancer) are now firmly established. PSA test kit producers and their European customers should have the possibility to validate their test systems with an EU-PSA standard.(1) Clinical study. Establish reliable clinical and analytical criteria for early diagnosis and prevention of the disease (analytical behaviour of the various available PSA measurement methodologies, and reliable and realistic screening cut-off limit for this marker).(2) Certified PSA Reference Material. Produce a certified PSA reference material, for standardisation of commercial PSA test systems, allowing harmonisation of methods and results within the EU, in compliance with the Community Directive on In Vitro Diagnostics.(1) Clinical study. So far 450 volunteers have been studied according to the work programme. Initial results lead to preliminary observations: based on a cut-off level of >3.0 ng/ml PSA, cancer detection rates are around 3%, with a reduction of necessary biopsies of 55%. Assay methods do not always correlate, especially in the critical area of 3.0-4.0 ng/ml. The usefulness of age referenced PSA values is not obvious. Information from free/total PSA ratios are not straightfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Manipulating different arms of the immune system to orchestrate tumor-specific immunity and enhance tumor clearance' (IMMUNOTHERAPY), addressing dissemination and exploitation.

assistant: **Impact**

Killing of cancer cells with an oncolytic adenovirus is an immunogenic phenomenon and can therefore be utilized for breaking the immunological tolerance of a tumor.Two complementary strategies can be used to enhance the T cell response towards the tumor: A) recruiting Dendritic Cells (DCs) to the tumor site to augment peptide loading onto MHC I; B) specific activation of DCs at the tumor site to increase their expression of co-stimulatory molecules for enhancement of cross-priming and T cell activation rather than cross-tolerance.As our first aim, we propose to generate three different capsid-modified oncolytic vectors expressing granulocyte-macrophage colony-stimulating factor (GM-CSF). The transgene will be driven by a replication-coupled adenoviral promoter to ensure GM-CSF production exclusively in tumor cells (an oncolytic virus replicates only in tumor cells). GM-CSF is a potent cytokine that enhances the function of antigen presenting cells (APCs) by the maturation, activation, and recruitment of DCs, macrophages and monocytes.All biologic responses crucial for DC functioning are influenced by signaling through the Toll-like receptors (TLRs), and TLR9 in particular is a key bridge between the innate and adaptive response. We propose, as our second aim, to generate an oncolytic vector containing CpG-stimulating sequences in its genome to combine oncolytic cell killing with effective delivery of CpG DNA to the endosome, where TLR9 is located.Finally, we will combine the two strategies described in aims 1 and 2, generating oncolytic vectors that are able to secrete GM-CSF for recruiting APCs to the tumor and at the same time to stimulate TLR9 in these cells. Overall we propose to capitalize on the entry biology of adenovirus for stimulation of TLR9 coupled with tumo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Study and optimization of gold plating processes' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The objective of this project is to study and optimize existing industrial gold plating pro- -cesses of wafers such that the treated components on it meet the required quality at reaso nable cost. The following research steps are considered: - study of known and available wafer plating cells through analysis and measurements, - application and evaluation of the dilute solution model" - solver, developed by the applicant during the BE92-5 187 project and continued in the BE95- 1232 project, - optimization of cell geometries, electrode configurations, flow conditions, ... using the model, realization of optimal designed cells and practical evaluation. Training content (objective, benefit and expected impact) During the project many practical problems and limitations of a real industrial plating pro- cess will be encountered. These are complementary to the firm theoretical knowledge of the applicaht such that he will become a highly qualified electrochernical design- engineer. Members of the host will acquire better theoretical insight and tools to improve their processes. Links with industry / industrial relevance (22) The research is directly related to gold plating of electronic components. When success- ful, the methodology and obtained results will enable improvements of many other plated products. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Farm systems that produce good Water quality for drinking water supplies' (FAirWAY).

assistant: **Innovation**

Safe drinking water is vital for human health. Diffuse pollution of nitrogen and pesticides from agriculture is the main obstacle to meet drinking water quality targets. Policies to protect drinking water resources have not achieved a consistent effectiveness in all member states. The objective of FAIRWAY is to review policy, governance and farm water management approaches to protect drinking water resources in the EU and to identify and further develop innovative measures and governance approaches which will simultaneously increase the sustainability of agriculture. The FAIRWAY partners form a unique blend of researchers, farm advisers and consultancies and is built on 13 case studies (‘living labs’) in 11 different EU countries, which will form the core of a multi-actor platform, underpinning all FAIRWAY work packages. Equally important is the upscaling of successful practices from case studies to the regional, national, and EU scales, emphasising the role of effective communication and extension tools developed in FAIRWAY. The outputs will provide a blueprint for multi-actor engagement across different scales, which will allow agriculture and water policies to be addressed in a more integrated way. FAIRWAY will i) increase the scientific understanding of the relationship between agriculture and drinking water protection, ii) increase the understanding for the social, technical and economic barriers to practical implementing of measures (iii) deliver innovative measures and tools to overcome these barriers, iv) develop protocols and data-sets for monitoring of farming practices and water quality, v) develop effective governance approaches for small to large water supplies, and vi) increase awareness and involvement of farmers and other citizens in the monitoring and g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Primitive chemistry in planetary atmospheres:  From the upper atmosphere down to the surface' under Horizon 2020.

assistant: **Concept**

The presence of organic compounds was essential to the emergence of life on Earth 3.5 to 3.8 billion years ago. Such compounds may have had several different origins; amongst them the ocean-atmosphere coupled system (the primordial soup theory), or exogenous inputs by meteorites, comets and Interplanetary Dust Particles. Titan, the largest moon of Saturn, is the best known observable analogue of the Early Earth. I recently identified a totally new source of prebiotic material for this system: the upper atmosphere. Nucleobases have been highlighted as components of the solid aerosols analogues produced in a reactor mimicking the chemistry that occurs in the upper atmosphere. The specificity of this external layer is that it receives harsh solar UV radiations enabling the chemical activation of molecular nitrogen N2, and involving a nitrogen rich organic chemistry with high prebiotic interest. As organic solid aerosols are initiated in the upper atmosphere of Titan, a new question is raised that I will address: what is the evolution of these organic prebiotic seeds when sedimenting down to the surface? Aerosols will indeed undergo the bombardment of charged particles, further UV radiation, and/or coating of condensable species at lower altitudes. I expect possible changes on the aerosols themselves, but also on the budget of the gas phase through emissions of new organic volatiles compounds. The aerosols aging may therefore impact the whole atmospheric system. An original methodology will be developed to address this novel issue. The successive aging sequences will be experimentally simulated in chemical reactors combining synchrotron and plasma sources. The interpretation of the experimental results will moreover be supported by a modelling of the processes. This complem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Best in class Deep Learning Predictive Model' under Horizon 2020.

assistant: **Concept**

HPA S.r.l. has reimagined the way predictive analytics services are made today, with a new Forecast-as-a Service model, based on cutting-edge deep learning algorithms that proved wide applicability in multiple vertical industries.After validating the problem/solution fit, HPA has engaged 3 prospects in the Energy, Technology and Media forecasting domains to prepare some Proofs of Concept and benchmark the solution. It’s also worth pointing out that no similar tools exist in the case of the second and the third verticalizations.The novelty of this solution consists of the following unique selling points:1.BEYOND predictive models outperforms most used competitor solutions in terms of accuracy (on average, 5% of error against 12-38% of errors by competitors) and speed. An early adopter of BEYOND operating in the energy trading market, demonstrated that increased accuracy provided by our model can result in a yearly operating margin increase of at least €120.000. 2.BEYOND will overcome adoption and usage barriers for many businesses providing easy-to-use models that require little knowledge from users with different skill levels from beginners to experienced analysts. 3.As a Forecast-as-a Service model, BEYOND will be offered with a flexible pricing strategy that will allow installation costs drop in a range between 50 to 90 % and long term costs decrease by a minimum of 10% up to more than 70%.Thanks to the SME Phase1 funding, HPA will be able to: a) finalize the Minimum Viable Product (i.e. development of programming language custom libraries, output formats and integration of third-party datasets); b) design the web application; c) assessment of more industry verticalizations and the search of corresponding prospects; d) set-up a massive promotional/communication plan t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart Energy Efficient Middleware for Public Spaces' (SEEMPubS), addressing dissemination and exploitation.

assistant: **Impact**

SEEMPubS specifically addresses reduction in energy usage and CO2 footprint in existing Public buildings and Spaces without significant construction works, by an intelligent ICT-based service monitoring and managing the energy consumption. Special attention will be paid to historical buildings to avoid damage by extensive retrofitting. SEEMPubS will provide control of appliances to effortlessly optimise energy efficiency usage without compromising comfort or convenience and offering decision makers strategies and tools needed to plan energy saving measures. SEEMPubS will make use of the service-oriented middleware for embedded systems being developed in the Hydra project and use its huge potential to create services and applications across heterogeneous devices to develop an energy-aware platform. The SEEMPubS platform will provide necessary functionality and tools to add energy efficiency features to monitor dynamic sensor data in real time, taking advantage of natural resources (like daylight and solar energy) and controlling the operation of both passive and active environmental systems to ensure the best possible comfort conditions with the most efficient use of energy.SEEMPubS will use its real-time energy-awareness services for all users of the Public Space and combine awareness services with a community portal. This will enable collective, community activity motivating positive competition in saving energy, complemented by courses on towards the education on energy efficiency and sustainability. The functionality of this system will be demonstrated on existing buildings at the Politecnico Campus  like the Valentino Castle. The validation of the most significant SEEMPubS results will allow to elaborate an energy efficient model for existing buildings and public sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Boosting Regional Investments in RTD - Guiding Europe to Growth' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

In the BRIDGE2Growth project European regions are answering the call for delivering on EU RTD objectives and for meeting the challenges of the knowledge-driven economy head on. The knowledge-driven economy calls for investments in knowledge.It calls for creation of regionally based innovation poles, where the diffusion and absorption of knowledge between all key stakeholders in the innovation system is mediated by a regional policy framework that facilitates and proactively encourages involvement and investment in RTD.The mission of the BRIDGE2Growth project is to provide European regions with the knowledge needed to develop RTD policy frameworks that:1) Mobilize and integrate regional RTD environments and stakeholders,2) Build public-private partnerships facilitating investments and involvement in RTD,3) Ultimately delivers growth and jobs to European citizens.The aim of BRIDGE2Growth is to rise to the challenge of boosting private investments in research. The project will especially explore ways to promote SME involvement and investment in the RTD process and thereby mobilize the massive resources of the European SME community. The project will investigate three essential topics for building successful RTD policy frameworks:-The impact of clustering and net working on SME involvement and investment in RTD.-Sources of funding for SME RTD investments -Complementarities of regional and private investments in RTD.Specifically the project will:-Map the regional investment environments and identify the barriers for increased private investment-Develop, adapt and validate policy guidelines, tools, templates and training schemes for regional authorities and policy-makers-Package and disseminate policy guidelines, templates, tools and training schemes in the BRIDGE2Growth Hand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel Ordered Micro and Mesoporous Organic-Inorganic Hybrid Materials with Crystalline Structure' (HYBRIDMAT).

assistant: **Innovation**

The research area is focused on the synthesis of periodic mesoporous materials whose polymeric framework is composed of both inorganic and organic fragments. The materials have a highly ordered structure with well-defined external morphologies reflecting t he symmetries of the pore arrangement structure, whose ordering is higher than that of the conventional mesoporous materials. These characteristics give to these materials a higher thermal and hydrothermal stability than that of conventional mesoporus mate rials, whose structure was formed by amorphous silica. Moreover, these novel hybrid organic-inorganic materials will show very interesting properties of hydrophobicity-hydrophilicity, which are unknown in materials with similar porous characteristics. The synthesis procedures- e.g. to polymerisation of organosilanes, containing two or more alkoxysilyl groups, in the presence of surfactant- can be applied to the synthesis of a variety of organic-inorganic hybrid mesoporous materials with a highly ordered str ucture. This ability to incorporate a variety of bridging organic and organometallic species makes possible to generate new materials with interesting chemical, catalytic, mechanical, electronic, optical and magnetic properties. On the other hand, a parall el study will be made but following a traditional methodology of hydrothermal synthesis of zeotypes, to the preparation of new hybrid organic-inorganic materials, but within the microporous range. In conclusion, the development of this type of materials is a major breakthrough in the field of porous materials, opening new opportunities for fine-tuning porous structures, surface and framework properties by judicious choices of the organic groups incorporated and the synthesis conditions employed. These prope rti