RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'YARNSCAPE: Ecological Economies of Ancient Textiles' (YARNSCAPE) under Horizon 2020.

assistant: **Objectives**

“YARNSCAPE: ecological economies of ancient textiles”, will investigate the relationship between textiles and the emergence and expansion of early complex societies, through examination of published data from the eastern Mediterranean and western Asia in the 4th and 3rd millennium BCE, and by testing a set of innovative methods against an in-depth study of primary data from a field site on the Milesian Peninsula (Turkey). Accumulated archaeological and historical data hint at a deep cogenerative relationship between complex urban or market-style economies and textiles, but the impact of cloth on long-term economy and environment has been too often been sidelined as ephemeral. There is therefore a critical need to develop innovative techniques to access the impact of textile industries over the longue durée. Through training in Spain, Denmark and Germany in specific advanced approaches to 1) cloud-based geoprocessing of multi-temporal remote sensing data; 2) spatial analysis of ancient landscapes; 3) multi-proxy palaeoenvironmental indicators of fibre production; and 4) ethnoarchaeological study of agroeconomy of textiles; the project will enable the ER to develop a robust, cutting-edge toolkit and set of theoretical approaches to ancient fibre production and their economies. This will place the ER in position to design a global comparative project devoted to delineating and explaining the relationship between social complexity and textile production.


**Keywords:** Textile Production, Fibre and Yarn Agro-Economies, Human Impact on Landscape Ecology, Remote Sensing, GIS, Economic History, Archaeological Survey, Complex Society
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Optimal Local Algorithms via Topology-Sensitivity'.

assistant: **Concept**

Considering the rapid growth of data sets and network sizes over the past decade, there is little doubt that the future of computation is distributed. One central aspect lying at the heart of distributed algorithms is the question of locality: what can be computed using only local information, and how much information is needed? While answering this question is essential for obtaining highly efficient algorithms for many important distributed problemssuch as load balancing in massive networks, locality is a fundamentally important concept also in many other fields of algorithmics, such as classical sequential algorithms, massively parallel algorithms, dynamic algorithms, sublinear algorithms, streaming algorithms, or online algorithms.In the context of distributed algorithms, a careful analysis of recent research on impossibilities reveals the key challenges in understanding localityand therefore in designing optimal algorithmsfor many graph problems: understanding 1) how to solve tree-like structures efficiently and 2) how to explicitly exploit any deviations from a tree-like topology algorithmically. The goal of this proposal is to gain a fundamental understanding of locality via the novel concept of topology-sensitive algorithms that precisely addresses these key challenges by explicitly exploiting local topological features in the input instance. Such an understanding will result in optimal algorithms and tight complexity bounds for many important distributed problems, thereby resolving central questions in distributed algorithms that have been open for decades, laying the foundations for highly efficient and scalable algorithms in massive networks, and implying significant improvements over the state-of-the-art in a variety of other algorithmic fields. In a nutshel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Low-cost highly conductive high resolution structures for flexible \nlarge area electronics by high throughput \nlow temperature processing'.

assistant: **Concept**

The LOTUS proposal addresses the urgent need for a technology to produce the highly conductive patterns required for high throughput large volume manufacturing of flexible large area electronics. While all printed electronics need electric wiring" LOTUS specifically targets the applications the most advanced towards commercialization: flexible thin-film photovoltaics, RFIDs, and OLEDs for lighting.<br/>The general objective is to provide a simple, low cost, energy efficient, environmentally friendly and R2R compatible platform to produce highly conductive structures with high resolution. The interplay between materials researchers, technology developers and end users allows to generate solutions quickly and effectively with minimum investment and time and to achieve maximum output with minimum risk. This will also accelerate the transfer to mass production. The strategy is based on an integrated approach to address both the common needs and the specific requirements of the most representative applications.<br/>The platform developed will reinforce the leading position of the European Industry in flexible OLEDs, PVs, and RFIDs. Moreover, it will be beneficial to any flexible electronics including thin-film transistors, power converters, flexible batteries, printed sensors for biomedical use (point-of-care) and food protection/freshness applications. These devices presently at various stages of development also need an "electric wiring". Thus LOTUS will contribute to wealth creation and making new technology available to address societal needs. The technologies and materials generated will enable the European Community to be competitive with Asian and North American products (there are presently no conductive inks and sintering tools manufacturers in Europe). LOTUS projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The highly calcium-sensitive pool of granules in biphasic insulin secretion: Experimental and theoretical investigations' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Insulin is released from the pancreatic beta-cells in a biphasic manner in response to a step in the ambient glucose concentration, and the loss of first-phase secretion is an early marker of diabetes. Studies have shown that there exist pools of insulin secretory granules with different calcium sensitivities. The project will study the nature, regulation and role of the highly calcium-sensitive pool (HCSP) in pancreatic beta-cells. Special focus will be on its relation to newcomer granules", which fuse shortly after arriving to the membrane, during biphasic insulin secretion. We will apply a combination of well-established experimental methods such as patch-clamp techniques, life confocal and TIRF imaging, in novel combinations with knock-down of key exocytotic proteins, in particular Syntaxin and Synaptotagmin. The experimental part will be complemented and supported by modelling studies, building on our recently published model, which identified the HCSP with newcomer granules. This interdisciplinary project will test the model experimentally, and vice versa, use the model to suggest key experiments. The suggested work will complement the theoretical training of the fellow with hands-on experience."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'BRIDGING THE GAP BETWEEN ACADEMIA & CLINICAL TRIALS FOR THE DEVELOPMENT OF RARE DISEASE TREATMENTS VIA NUCLEAR MAGNETIC RESONANCE IMAGING (MRI)' (MRI), addressing dissemination and exploitation.

assistant: **Impact**

Rare diseases affect 36 million citizens in the EU with 75% of patients being children and 30% dying under the age of five. 94% of the 8,000 rare diseases lack approved treatments and the EU has created financial incentives for pharmaceutical companies (PhC) to develop suitable orphan drugs but they face difficulties through increasingly high development risks where a failed drug trial can cost €1.8bn on average. In order to lower their costs, PhCs outsource development work to Contractual Research Organizations (CRO) who specialise in specific task such as drug discovery or clinical trials but these CROs have significant limitations such as a lack of modern Nuclear Magnetic Resonance Imaging (MRI) methodologies, EMA/FDA compliance, contacts to clinical sites and restricted access to rare disease patient groups. We present MRI NETWORK, the first solution which bridges the gap between PhCs and clinical sites by providing an online network of expert clinical sites, full trial design, the most advanced MRI methodologies and smart automated MRI data processing & coordination. This project will be fundamental in bringing our technology to full market readiness and reach the 150,000 clinical sites and 36 million rare disease patients in the EU. Our company, CRIS, has been involved in 30+ clinical trials in the past 20 years and with our extensive commercial network of clinical sites, academic experts, pharmaceutical companies and the relevant regulatory institutions, we expect to generate €15.4m in profits with an ROI of 6.7 over 3 years. RD-MRI NETWORK creates a new market for clinical trials and MRI services in the EU and, next to 17 direct jobs, we will create 500+ new skilled jobs by allowing academics to receive adequate compensation for MRI services and increase industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targeting Cartilage Regeneration in joint and intervertebral disc diseases' (TargetCaRe).

assistant: **Concept**

Mobility, important for well-being, is seriously impaired by chronic low back pain and osteoarthritis in many people due to degeneration of cartilaginous tissue of the intervertebral disc and joint. To develop a treatment for these diseases this ETN aims to combine expertise in novel highly advanced drug delivery carriers with dedicated targeting tools, state of the art imaging techniques and expertise in stem cell and joint biology by training 15 young scientists in 12 partner institutes located in 5 different countries.We aim to achieve regeneration of damaged and degenerated tissues by employing targeting strategies tailored both to the pathology and the tissues involved. Regeneration of diseased tissues will be achieved by loading biologically active agents in state-of-the-art nanocarriers. The biologically active agents will stimulate the body’s own capacity to regenerate by attracting local stem cells or inhibit degeneration. Targeting will be achieved by A] injection with synthetic or natural hydrogels loaded with the nanocarriers or B] coupling diseased tissue-specific antibodies and specific hyaluronic acid moieties to the nanocarriers. Delivery and retention will be monitored by advanced in vivo and molecular imaging techniques to monitor distribution of the delivered compounds at the tissue level, as well as detect biological markers of regeneration.Major objectives:1] To establish a network of scientists skilled in the use of smart nanocarriers, unique approach of targeting by disease-specific molecules and application of innovative imaging tools. Supported by generic scientific and training in economical and clinical valorisation, these researchers can further implement these technologies in the musculoskeletal or other areas, both in academia and industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TETHIS-SBS-CTC: An innovative diagnostic testing platform to identify and characterize circulating tumour cells (CTCs) in blood samples.' under Horizon 2020.

assistant: **Concept**

Cancer is one of the most important causes of death worldwide, accounting for 8.8 million deaths. The rate of new cases is expected to rise by 70% in the next 2 decades, posing a huge challenge for the healthcare system. If diagnosed early and treated adequately, many cases would have a high chance of cure. This realization is driving the growth in the cancer diagnostics market. The detection and analysis of Circulating Tumour Cells (CTCs) encloses a huge potential for real-time monitoring of cancer cases. CTCs are considered a “diagnostic tumour marker” since they are the reflection of a metastatic aggression. We at TETHIS have developed a new diagnostic platform to characterize CTCs from liquid biopsy (i.e. blood). The combination of our expertise in nanotechnology and strong biology knowledge have led to the development of a Smart BioSurface (SBS) that creates a perfect environment to immobilize CTCs using a total capture approach. Compared to the state-of-the-art alternatives, our methodology does not require pre-enrichment or selection. Having validated this technology for cancer diagnostics at the pilot stage, this project is conceived to finalise the development and market preparation of this technology, culminating in a diagnostic platform for cellular, proteomic and molecular characterization of CTCs. The platform will have key applications, including diagnostics and monitoring in clinical settings, and drug discovery & therapy development in the pharma/biotech sectors. The Phase 1 of this project is dedicated to run a Feasibility Study that helps us evaluate the project from a technical, commercial and financial standpoint. Once the project is finished, we expect our platform to improve the diagnostic capability in the oncology sector, enabling earlier detecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Beta Cell Generation by Stem Cell-Derived Implants in Diabetes' under Horizon 2020.

assistant: **Concept**

Despite improved treatment, diabetes remains a chronic disease with major health risks and heavy burden on patients and society. Serious forms are caused by depletion in pancreatic beta cells and associated loss in insulin’s homeostatic control throughout life. Their cure requires restoration of a metabolically adequate beta cell mass. Implants of beta cell grafts prepared from human pancreases have shown proof-of-principle but also the need for developing a large-scale source for therapeutic cells. Our objective is to generate a functional beta cell mass by stem cell-derived implants in diabetes patients. A combined preclinical and clinical project will search recipient and implant conditions for formation and maturation of beta cells in subcutaneous implants of device-encapsulated pancreatic endodermal cells that are derived from human embryonic stem cells (hu-ES) and manufactured for clinical studies. We collected preclinical evidence for the therapeutic potential of this implant from comparison with clinically used human beta cell grafts. State-of-the art methods and markers have been developed to investigate the biology of implants and to monitor host immune and innate reactivity. This approach helps understand the basis for metabolic outcome and identify targets for improvement. Pilot studies examine the influence of the (auto)immune status of the patients. Data will determine transition to clinical efficacy studies, or indicate the need for further laboratory development. Implants in preclinical models will guide modifications in clinical protocols, and explore the biologic properties of grafts derived from human induced pluripotent stem cell (iPSc) as can also be prepared from diabetes patients. Our consortium joins innovating cells, methods, markers and minds i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A real-time Voltage controlled distribution transformer for power grid stabilization in the smart-grid era allowing for 100% adoption of sustainable power sources' under Horizon 2020.

assistant: **Concept**

In recent years we witness an ever-increasing penetration of distributed and renewable energy sources such as solar panels and wind turbines to the market place. These energy sources cause voltage instabilities in the power grid as they inject uncontrolled power in various locations along the power grid. This instability issue is the main obstacle that holds back further penetration of renewable energy in to the power grid.Existing methods of real time voltage control in the distribution network are both expensive and have relatively low performance and include replacing already installed distribution transformers with newer transformers. We suggest the application of an add-on unit that enhances existing and already-installed distribution transformers, for real-time voltage control with similar efficiency, cost and reliability as conventional transformer. The application of a large number of real time voltage controlled transformers in the power grid will result in reduced losses in the power grid and increased stability in face of distributed generation. Moreover, it will allow for adoption of a much higher percentage of renewables.The market for real time voltage controlled transformers has grown from zero in 2011 to 1B$ in 2017 and is expected to grow at almost 20% annually in the next 30 years. (“Global Smart Transformer Market (2016-2022),” Business Wire report, Sep 2016).Volex Power has a lab tested prototype (TRL 6) thoroughly tested with a 100 kVA load. The goal of this project is a feasibility examination of a fully functional 100 kVA Smart Transformer prototype, capable of voltage regulation in real time and under load in the real power grid alongside with a comprehensive business plan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding and PreDicting the Rapid development of storms: A new ForecasTing framework' under Horizon Europe.

assistant: **Concept**

Developments in numerical weather forecasting have been of great benefit to many sectors of society. However, state-of-the-art weather forecasting and climate models still struggle to predict the onset and development of convective storms over land. Such storms are associated with many destructive weather events including floods, hail, and lightning, and thus, any improvement in addressing these events remains keenly sought after. UPDRAFT will develop a new method for the representation of convective storm clouds in forecasting models, building a completely new theoretical framework that can overcome many of the problems with the current modelling approach. Recent studies by the ER have shown that some key physical mechanisms responsible for the initiation of convective storms are neglected by current models, which might explain the large biases associated with the prediction of these storms. In the new model to be developed during the fellowship, these missing mechanisms will be represented in a more physically-based picture for the development of convective clouds. The main objective of the project is to produce concrete evidence that the new framework can lead to much-improved forecasts of storms. Besides the immediate potential impact for weather prediction, the outcome of the fellowship will also help in improving our understanding of storms and their response to climate change. Convective clouds play an important role in the Earths radiative and hydrological budgets, so the project might help in improving climate models as well, supporting decision-making on adapting to climate change and mitigating the risks associated with many severe weather events.


**Keywords:** Convection, Clouds, Storms, Weather forecasting, Climate modelling