RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The discovery of future neuro-therapeutic molecules' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

NEUROscreen is an industry-lead project combining novel neural stem cell bioassays & post-genomic chemical genetics to discover potential drugs of relevance to neurological diseases, regenerative medicine & cancer. Small molecule inhibitors of the growth of clonal, human neural cancer stem cells have the prospect of being unique medicines targeting the elusive cancer stem cell. Chemical modulators augmenting the growth, survival or differentiation of normal brain cells have a prospect as preventative or regenerative medicines for neurodegenerative diseases i.e. Alzheimer's, stroke & Huntington's disease. The consortium will use quality controlled cell lines & genetic engineering technology to design unique bioassays with which the biological modulating capacity of small molecules will be evaluated in a multi-replicate manner. Advanced chemistry will be used for the intuitive design and synthesize of biologically active molecules. Screening will be achieved with cells made to a quality & quantity via innovative bioprocesses & handled with state of the art robotics. The project will enhance the utility of the cell lines by delimiting the in vitro neural potency of the stem cells; ongoing determination of differentiation capacity serves as a rigorous confirmation of utility. The project will focus on specific activities germane to a wider applied research field than its seeding project EuroStemCell. The consortium & project have been designed with a crucial alignment in mind to objectives of the Work Programme/Specific Programme for Integrating & strengthening the ERA i.e. gender & innovation aspects in research, international cooperation (3 countries & a new member state) and fostering ethical awareness in research involving human stem cells. More than 50% of partners rep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'AI-driven multiscale methodology to develop Transparent Wood as sustainable functional material' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

AI-TranspWood ambition is to create an AI-driven multiscale methodology for new Safe and Sustainable by Design (SSbD), and functional wood-based composites and demonstrate the concept for Transparent Wood (TW), a promising composite with potential applications in several industrial fields, such as construction, automotive, electronics and furniture. By developing AI supported SSbD framework for TW, we contribute to European Green Deal by providing innovative sustainable materials and cost-effective tools for European industries paving the way towards green and sustainable transition. SSbD tools used by the chemicals and materials community with new transparent wood materials, increases the innovation capacity of SMEs and industry for future sustainable products.With the help of AI-tools and advanced experiments we develop multiscale models from the atomistic scale to continuum for the manufacturing process and the mechanics of the transparent wood allowing for virtual screening of bio-sourced alternatives for hazardous and petrochemical-based chemicals required for manufacturing Transparent Wood using the current solutions. The built computational models are openly shared within the European environment for scientific software (EESSI). The user-friendly surrogate model is also made available in the VTT Modeling Factory environment, along with an LCA tool, for industrial use. Four TW business cases are conducted, with the aim to be commercialized in the construction, automotive, electronics and furniture industries. The SSbD framework will guide the whole creation of the TW products providing a competitive advantage to the European manufacturers interested in introducing the TW composites in the European market, also as substitutes of glass and plastic in various applica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantifying the effects of vegetation change on surface temperature change', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Global climate is changing rapidly, and vegetation distribution is shifting as a consequence. Vegetation change feeds back to climate change by altering the surface albedo, soil heat flux, and sensible and latent heat flux, and thereby the surface energy balance and surface temperature (Ts). For these reasons, perturbations to the radiation balance due to vegetation cover change have been argued to be as important as changes in atmospheric dynamics and composition for global and regional temperature, yet the mechanisms by which vegetation change alters Ts across time and space are rarely investigated. Here, we propose to quantify the role of land cover change on Ts change in global ecosystems using the FLUXNET database with a focus on the European sub-arctic. The purpose is to explore the mechanisms that result in Ts change to build mechanistic understanding of these processes using global examples. The focus on sub-arctic ecosystems builds from excellent data coverage from the IPY-ABACUS project and European collaborators, and is pertinent given that high-latitude ecosystems are currently experiencing the most acute effects of global change. The analysis builds upon a recent manuscript by some of the proposal team that employed a partial derivative analysis of the surface energy balance to determine that abandoned field to forest transition had a cooling effect on the land surface as the cooling effects of enhanced evapotranspiration outweighed warming effects from decreased albedo on the annual time scale. Regional findings will then be coupled to the Ts product from the MODIS satellite to quantify the effects of recent arctic greening and drought on the surface radiation balance and global climate. We envision that this study will improve representation of the land s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synthetic Cell Biology: Designing organelle transport mechanisms' under Horizon 2020.

assistant: **Concept**

Imagine being able to design into living cells and organisms de novo vesicle transport mechanisms that do not naturally exist?  At one level this is a wild-eyed notion of synthetic biology.But we contend that this vision can be approached even today, focusing first on the process of exocytosis, a fundamental process that impacts almost every area of physiology.  Enough has now been learned about the natural core machinery (as recognized by the award of the 2013 Nobel Prize in Physiology or Medicine to the PI and others) to take highly innovative physics/engineering- and DNA-based approaches to design synthetic versions of the secretory apparatus that could someday open new avenues in genetic medicine.The central idea is to introduce DNA-based functional equivalents of the core protein machinery that naturally form (coats), target (tethers), and fuse (SNAREs) vesicles.  We have already taken first steps by using DNA origami-based templates to produce synthetic phospholipid vesicles and complementary DNA-based tethers to specifically capture these DNA-templated vesicles on targeted bilayers. Others have linked DNA oligonucleotides to trigger vesicle fusion.The next and much more challenging step is to introduce such processes into living cells. We hope to break this barrier, and in the process start a new field of research into “synthetic exocytosis”, by introducing Peptide-Nucleic Acids (PNAs) of tethers and SNAREs to re-direct naturally-produced secretory vesicles to artificially-programmed targets and provide artificially-programmed regulation. PNAs are chosen mainly because they lack the negatively charged phosphate backbones of DNA, and therefore are more readily delivered into the cell across the plasma membrane. Future steps, would include producing the transport v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cost, reliability, maintenance and availability' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The objective of the project is to develop a Life Cycle Cost (LCC) approach to assess the benefits and the most favourable method of introducing harmonised rules which ensure economic and safe maintenance of rolling stock outside the home network. In order to achieve this the following actions are required: 1) The provision of a consistent and comprehensive definition of all terminology used in railway vehicle life cycle cost calculations.2) The extension of the scope of current Life Cycle Costs procedures, to make them useful for strategic decisions as well as monitoring contract performance. This requires that all the factors which influence LCC are included. Amongst the factors to be included will be specification, design, production, reliability, maintenance, interaction with track, current collection and disposal.3) The determination of which financial analysis techniques are appropriately applied to Life Cycle Cost calculations.4) To identify strategies for the maintenance, reliability and availability of rolling stock when operating outside the domestic network which minimise the cost of interoperability.It is expected that the CRMA project will provide the following:1) A common understanding of Life Cycle Costing applied to rolling stock operation which is independent of the calculation model. This includes: (i) a consistent and acceptable set of terminology and (ii) a definition of all the elements which should be considered to form a complete understanding of Life Cycle Costs.2) A strategy for minimising the operational costs for operating away form the home network whilst maintaining high level of reliability and availability. 3) Support for the harmonisation of maintenance and reliability. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Boosting metabolism in T cells: a tool to improve T cell therapy for chronic lymphocytic leukemia patients' (BOOTCAMP) targeting Horizon 2020.

assistant: **Abstract**

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Novel targeted drugs are effective, but not curative. Moreover, prolonged use is associated with development of resistance, toxicity, and high economic cost. Allogeneic stem cell transplantation, which evokes a T cell mediated response, is potentially curative yet is associated with high graft-vs-host-related mortality. Therefore, an autologous T cell-based approach, e.g. chimeric antigen receptor T cells (CAR-T), is a highly promising strategy. However, in contrast to the success of CAR-T cells in aggressive leukemia, their effect in CLL is limited owing to a largely unexplained acquired T cell dysfunction in this disease setting. I recently found that CLL cells impose a reduction in mitochondrial fitness and altered glucose metabolism on T cells, which may underlie the acquired T cell dysfunction. Lending clinical significance to this finding, I observed that the success of CAR-T treatment in CLL patients is highly associated with their mitochondrial biogenic capacity. I therefore hypothesize that improving mitochondrial fitness of CAR-T cells may offer a path to cure CLL. I aim to: 1. Characterize the molecular mechanisms of metabolic alterations in CLL-derived T cells 2. Elucidate how CLL cells reprogram T cells metabolism3. Increase mitochondrial biogenesis and fitness in CAR-T cells to improve therapeutic efficacyTo achieve these goals, I will conduct an array of complementary molecular, metabolic, and genetic assays using patient samples and a murine model of CLL. To address therapeutic potential I will study murine and human CAR-T cells in which metabolic processes will be manipulated. This project provides crucial insight into the interplay between CLL and T cells, and the unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Photo-Induced Processes in oxalate network based nano-objects' (PhOxNa) targeting Seventh Framework.

assistant: **Abstract**

Interaction between light and matter is of fundamental importance in physical, chemical and biological sciences, because of a variety of applications, for instance in optical information technology devices, in lasers and lighting, and in solar-energy harvesting. Coordination chemistry provides a convenient tool to prepare solids with tailored optical properties. However, the actual use of such materials in devices requires processing of the compounds into well-defined and often size-reduced particles. This project aims at the preparation of nano-objects, starting from oxalate-based networks, well known for their optical and magnetic properties. For example, [M(bpy)3][NaCr(ox)3] 3D networks are known to present a photo-induced energy migration process within the CrIII cations over large distances (up to 100 nm when M = RuII) or an unusual spin crossover behaviour when M = CoII.The first step will be the adaptation of nanochemistry methods (reverse-micelles technique and others…) to this family of compounds, in order to obtain size-controlled particles and, in a second step, functionalized nanoparticles and core-shell nano-objects. With [Ru(bpy)3][NaCr(ox)3] nanoparticles, the influence of size reduction on the energy migration process will be investigated. Functionalized nano-objects, either by grafting complexes on the surface or by epitaxial growth of a different oxalate network shell, will then be used to study the energy transfer from the core particle to the surrounding. Finally, [Co(bpy)3][LiCr(ox)3] will be prepared to study the size reduction effect on the spin crossover process of the [Co(bpy)3]2+ cations.  Thus, this project is expected to give a better insight on the effect of size-reduction on the photo-induced energy migration, energy transfer and spin cross
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Generic Formatting for Storage' (G-FORS).

assistant: **Concept**

Reduce cost of European programme production by providing content efficiently and cost effectively through developing and demonstrating an improved broadcast chain compared to tape-based systems. G-FORS will provide flexible, fast non-linear editing, connection with telecommunications channels, storage of HDTV/electronic film images and faster-than-real-time data transfer. A generic file wrapper" format for the distribution and storage of television images will provide interoperability between acquisition storage and contribution systems.Transcoding techniques will be developed to increase the flexibility of the proposed system. A broadcast chain consisting of camcorder, solid-state/disk based camcorder cartridge, server, transcoders and very high-resolution viewer for monitoring images will be delivered. Results will be communicated to standardisation bodies.Objectives:The goal of the G-FORS project is to reduce the cost of European programme production. This will be achieved by handling content efficiently and cost effectively throughout the broadcast chain compared to tape-based systems. The project will provide the flexibility and speed required for non-linear editing, connection with telecommunications channels, and storage of HDTV / electronic film images and faster than the goal of the G-FORS project is to reduce the cost of European programme production. This will be achieved by handling content efficiently and cost effectively throughout the broadcast chain compared to tape-based systems. The project will provide the flexibility and speed required for non-linear editing, connection with telecommunications channels, storage of HDTV / electronic film images and faster than real time data transfer. A generic file "wrapper" format will be created for the distributi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Atomic Quantum Emitters in 2D Frameworks' (AQE2D).

assistant: **Concept**

The ability to create and control connected quantum states established the advent of quantum information technologies (Q-IT). Manipulation of the electron spin associated with colour centres in solid state crystals is one of the pillar technologies that could eventually push Q-IT beyond cryogenic environments. Exploitation of the full potential of these atomic qubit systems is, however, hampered by two key challenges: the lack of atomistic insights into their properties, and the ability to place them with the required fidelity and atomic spatial precision.Here I propose to converge recent breakthrough developments in the synthetic control of two-dimensional (2D) materials and ultra-fast, single-atom resolving probes to overcome these challenges. Specifically, I will develop a platform for electro-optically addressable spin qubits (Atomic Quantum Emitters, AQEs) in 2D materials based on atomic dopants in transition metal dichalcogenide (TMD) monolayers and molecular spin systems in 2D covalent organic frameworks (2D-COFs). These systems will provide an ideal platform to generate AQEs by chemical design, to control the mesoscopic environment averting variability between emitters, to achieve atomically precise spatial placement, to identify and eliminate decoherence channels, and to develop high-fidelity scalable pumping schemes.The proposed construction of a spin-polarized ultrafast THz scanning probe microscope with optical detection capabilities will enable the direct correlation of structural, electronic, magnetic, and optical properties of individual AQEs with simultaneous atomic spatial resolution and picosecond time resolution. This will open new frontiers in the spatio-temporal characterization and control of solid-state AQE systems. The atomically precise engineer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New exchange bias systems for magnetic applications' to be submitted under Fifth Framework.

assistant: **Abstract**

The NEXBIAS RTN is concerned with the phenomena of exchange bias materials where an anti- ferromagnetic material is deposited or grown on the surface of a ferromagnetic material. In this way the magnetization of the ferromagnet is pinned to the antiferromagnet and hence cannot reverse in the normal way. Such materials have current applications in magnetic recording read heads but also have great potential for the development of new sensor systems and particularly new solid state non-volatile memory chips devices (e.g. MRAMs) for computers. The phenomenon of exchanging biasing was discovered in the 1950s and yet, surprisingly, is not fully understood. It has recently become clear that different models of the origin of the effect are required for different materials systems. Hence it may be that more than one intrinsic parameter controls the behavior of such systems. A problem with a complexity on this scale cannot be addressed in a single laboratory and hence collaboration is essential. The principle scientific objective of the NEXBIAS RTN is to try and establish the fundamental mechanisms of exchange biasing in a range of materials. A strong team of six academic laboratories together with an industrial partner (Siemens) forms the network. The network will fabricate a range of materials using a variety of techniques including MBE, sputtering, nanowires and fine particles to try to elucidate the fundamental origin of the exchange biasing effect. Techniques such as ion irradiation and doping with impurities will be used to distinguish between interface and bulk effects. An advanced characterization programme involving the use of in- site tools and ex-site instruments extending out to the use of large experiments at central laboratories for X-ray studies will be implemented