RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Trans-Atlantic Platform for the Social Sciences and Humanities'.

assistant: **Objectives**

Major research funders in Europe and the Americas have decided to join forces to build a Trans-Atlantic Platform (TA-P) in order to create and establish effective and structured multi-lateral engagement between research funding agencies in Europe and the Americas. This Trans-Atlantic-Platform is a global first, representing a collaborative effort of key Humanities and Social Science funders on a scale not previously entertained. This Platform will break down the barriers to further co-operation between funders and also lead to heightening understanding of the contribution of Social Sciences and Humanities disciplines in a global context. As a first major step, the proposal includes key partners from Europe, Canada, Mexico and Brazil. Efforts will be made to engage additional partners from Europe and particularly the Americas.The Platform will support agencies in stepping up international collaboration: though sharing best practices, networking and closer coordination of existing activities and the establishment of new relationships to facilitate multidisciplinary networking across the Social Sciences and Humanities in their widest remit both with respect to research and geographical areas. A comparative analysis of the partners involved in the Platform and a mapping of existing research networks will be issued to identify barriers and challenges to transnational collaboration and to formulate successful mechanisms to work together efficiently beyond the bilateral approach. In order to become more than a ‘network of networks’ and to bring genuine added value the Platform will be focusing on key topics. As an initial focus, the Platform has agreed upon a plan to pilot new principles of transnational collaboration through concrete joint programming focusing on the theme of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Capturing the natural genetic complexity of a simple neural circuit' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The egg-laying circuit of the nematode Caenorhabditis elegans is one of the best-understood model neural circuits. Yet, how genetic changes in the circuit translate into natural behavioral variation within the species remains limited. Characterizing standing genetic variationan inherent feature of most animal populations and essential for evolutionis a fundamental aspect of understanding any model system. I will study the genetic diversity underlying C. elegans egg-laying behavior by focusing on an ecologically important phenotype: matricidal hatching (MH). MH occurs when egg laying is so limited that larvae are forced to hatch inside the parental body. While usually a plastic response to poor environments, MH is constitutive (CMH) in multiple divergent lineages: this represents a chance to study how different molecular pathways converge on the same phenotype. I will identify the molecular causes of CMH in different natural strains and I will further study how CMH can emerge through novel genetic interactions in hybrid strains derived from crosses between non-CMH parents. Traditionally, genome-wide association (GWA) and linkage mapping in C. elegans are complicated by the species strong linkage disequilibrium and the labor-intensive construction of mapping panels, respectively. To overcome this, I will employ state-of-the-art methods and novel resources to identify Quantitative Trait Loci (QTL) and their underlying molecular variants that lead to CMH. This project will allow me to learn the handling of a new model organism, broaden my molecular biology and bioinformatics skills, and grow as a scientist by expanding my experience in genotype-phenotype analysis from single proteins to genome-wide studies of a complex phenotype. As the first study to examine the effects of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NMR tools for drug design validated on phosphatases' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In this STREP we intend to use cutting-edge nuclear magnetic resonance (NMR) techniques to develop a fast, integrated approach to support structure-based drug design. The project will speed up drug design efforts for typical drug targets and will shorten t he lead-time for new drugs. We will develop fast, reliable and robust NMR techniques for exact structural and dynamic characterization of drug-receptor interactions at atomic resolution, thus enabling and/or improving the potential for directed development of drugs exhibiting a maximum of desired interaction characteristics in a relatively short time. Protocols for obtaining the NMR data needed for the characterization of proteins, inhibitors and protein-inhibitor complexes will be developed, starting from known X-ray structures, thus establishing a tight connection between NMR and X-ray technology and exploiting optimally the complementary strengths of both techniques. The new NMR technologies will be complemented by computer modelling for protein-inhibito r complexes and by advanced tailored protein expression methods. In order to show the impact for drug development, the new approach will aim at phosphatases, a major class of drug targets with broad medical implications. A majority of cellular functions d epend on phosphorylation by kinases and de-phosphorylation by phosphatases. High eukaryotes encode approximately 500 kinase and 100 phosphatase schemes, corresponding to 3% of the genome. While the importance of kinases in cellular regulation led to substa ntial drug design activities, the importance of phosphatases has only been appreciated recently. Phosphatases regulate insulin signalling, cell growth and the cell cycle. Therefore, the inhibition of phosphatases is perused for the treatment of diabetes, o besit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biological patinA for arcHaeological and Artistic Metal ArtefactS' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The nature of the corrosion products present on the surface of artistic and archaeological metal artefacts is intrinsically related to the environmental context (atmospheric or burial). In order to effectively protect and inhibit the corrosion of such metal objects, the practices adopted should take into account the nature of the patina and its corrosion behaviour. However, the treatments so far employed are organic protective coatings, which do not consider the difference in terms of patina composition and corrosion products stability and simply create a barrier against aggressive environments in a non-selective way. A multidisciplinary project BAHAMAS is here proposed for developing an alternative biological treatment as a novel approach for the conservation-restoration of metal artefacts. The research activity aims at chemically and specifically modifying existing corrosion products into more stable and less soluble compounds while maintaining the surface’s physical appearance. Some species of fungi have been already reported for their ability to transform metal compounds into metal oxalates, which are known to be insoluble and high protective compounds towards corrosion. Thus, the participants will exploit this potential for the transformation of existing corrosion patinas into metal oxalates. Some promising results have been obtained after a first attempt on bronze standards with copper hydroxysulphates and copper hydroxychlorides patinas. The research work will investigate the formation mechanisms and adhesion properties of the newly formed metal oxalates on different metal substrates (copper, iron and silver), which are frequently found in cultural heritage artworks. The collaboration between the Swiss National Museums, the University of Neuchâtel and the researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biogeochemical insights on the entry of seawater lithium into marine ecosystems' (BESTLiME).

assistant: **Innovation**

Lithium (Li) is essential for the global energy transition, with rapidly increasing use in rechargeable batteries. As Li release into the ocean is expected to rise, its effects on marine ecosystems remain largely unknown. Limited evidence suggests Li can accumulate in lower trophic levels and be incorporated into biominerals during calcification of shells and skeletons, but the ecological risks and biogeochemical pathways of Li are poorly understood.BESTLiME addresses these critical gaps at the interface of biology, mineralogy, and geochemistry. It pursues two main objectives: (1) to quantify Li bioaccumulation in diatoms, key primary producers at the base of marine food webs, and (2) to investigate Li incorporation into biominerals produced by corals and bivalves, organisms central to ecosystem health and carbon cycling. To achieve these goals, diatoms, bivalves, and corals will be cultured under controlled conditions with elevated Li. Fibroblast models will be used to simulate cell membranes and evaluate Li transport into cells. Li concentrations will be monitored in culturing fluids and biomass to calculate bioaccumulation. Biominerals formed during culture will be analysed with advanced electron microscopy and geochemical techniques. Two short visits to partner institutions will examine Li distribution in the biomaterials and characterize biominerals, providing complementary training and strengthen collaborations.BESTLiME will deliver the first systematic dataset on how Li enters marine life. The findings will refine geochemical proxies, inform sustainable ocean and resource management, and guide safe recycling strategies. For the fellow, a geochemist with limited biological experience, this project offers advanced training in marine biology and biomineralization. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Coordination of Automated Road Transport Deployment for Europe'.

assistant: **Objectives**

Automated Road Transport (ART) is seen as one of the key technologies and major technological advancements influencing and shaping our future mobility and quality of life. The ART technology encompasses passenger cars, public transport vehicles, and urban and interurban freight transport and also extends to the road, IT and telecommunication infrastructure needed to guarantee safe and efficient operations of the vehicles.In this framework, CARTRE is accelerating development and deployment of automated road transport by increasing market and policy certainties. CARTRE supports the development of clearer and more consistent policies of EU Member States in collaboration with industry players ensuring that ART systems and services are compatible on a EU level and are deployed in a coherent way across Europe. CARTRE includes a joint stakeholder’s forum in order to coordinate and harmonise ART approaches at European and international level. CARTRE creates a solid knowledge base of all European activities, supports current activities and structures research outcomes by enablers and thematic areas.CARTRE involves more than 60 organisations to consolidate the current industry and policy fragmentation surrounding the development of ART.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Photometabolic Self-Replication' (PSR).

assistant: **Concept**

This research project aims to address one of the Grand Challenges in contemporary science: the de-novo synthesis of life. More specifically we aim to achieve, for the first time, (i) development of replicators that feature a primitive photometabolism, and (ii) Darwinian evolution of such fully synthetic molecules. These ambitious aims are firmly grounded on the unique expertise of the host lab (self-replicating molecules) combined with the strong expertise of the ER (self-assembly and photochemistry). This combination will enable the adaptive integration of a photoactive co-factor (e.g. a porphyrin) with replicator fibers which will activate photocatalytic production of singlet oxygen. This singlet oxygen promotes the oxidation of thiol building blocks into “food” (i.e. small disulfide macrocycles) which the replicator can utilize to make copies of itself. In the final phase of the project we will operate the photometabolic self-replicating system under far-from-equilibrium conditions in an open flow system in which replication competes with physical removal (“death”). This regime should allow for Darwinian evolution, provided that replicator mutation is facilitated by providing different building blocks. In order to survive, replicators need to replicate faster than they are being destroyed. Therefore, selection should favour the replicator with the highest catalytic efficiency. Overall, the designed systems will exhibit all aspects of Darwinian evolution: replication, mutation and selection. While evolution in biology requires long periods of time, herein we aim, for the first time, to realize evolution in a fully synthetic system within a short timeframe, and obtain photometabolic replicators with activities that have been improved through Darwinian evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Insecure Parents and Children: a Sequence Analysis Approach. A holistic investigation of the role of employment uncertainty in the reproduction of social inequalities.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The intergenerational transmission of social inequality follows several pathways throughout one’s life. Scholars have investigated the role of parental education, social class, income, and employment status. However, less is known about the effects of precarious jobs, albeit it is a common experience in post-Fordist societies, to the extent that, on average, one in four workers held a temporary contract in Europe. Moreover, workers experience disruptive levels of work-schedule instability and work-hour volatility. Employment uncertainty has been linked to lower income, job prospects, and health of the worker and their partner. Emergent literature has linked parents’ non-standard jobs to children’s development and educational path. In this project, I plan to analyze the link between parents’ employment trajectories and children’s outcomes, from perinatal to mental health and educational trajectory. I aim to make the following contributions. First, in the life-course framework, I integrate work and family trajectories of the adults acting in a parental role using multichannel sequence analysis. This approach allows us to focus on the timing, order and cumulative dimensions of disadvantage, both between the parents and over time. Second, I investigate the patterns at the intersection of social class, gender and migration background, using the Kitagawa-Oaxaca-Blinder decomposition. This method will help us disentangle the roles of composition and returns to life courses. Third, I explore how causally ordered multiple mediators —such as income, parental stress and health behaviour —can explain the observed patterns, by estimating path specific effects. Fourth, comparing different welfare regimes can provide insight on how to mitigate the effect of precarious work trajectorie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Management tool for the assessment of driveline technologies and research' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

In the running CEU Collaboration Programme on EV's, a working group has come into being, consisting of organisations with a long-standing experience in vehicle testing and with a vast knowledge of electric and hybrid vehicles. This group can be of great importance for the Task Force Car of Tomorrow, for national and local authorities, and for the European automobile industry. The latter will be invited to cooperate as the results of this progrmme could give it an extra advantage in the world-wide competition, especially if industrial organisations like EUCAR are enlisted in the activities. In this group authoritive organisations participate with experiences on databases and computer models, on testing vehicles, on user behaviour, on decision support systems and on dissemination of information. All organisations have experience in international cooperation. The main objective of the proposed programme is: to enable the CEU to assess the technical aspects and implications of conventional and nonconventional drivelines to: - to keep itself informed on the state of the art of drivelines of conventional, electric and hybrid drivelines for road vehicles as well as on vehicle design and construction developments aimed at reducing energy consumption and emissions; - to monitor progress of research and development activities by research institutes and OEMs; - to identify promising technologies and key areas for long-term technology developments; - to assess readiness of technologies for short-term marketing introduction; - improve European industry competitiveness through cross-correlation of European, American and Japanese technology methods. The sub-objectives of the programmes are: I) to make available test information on conventional and non-conventional drivelines; 2) to pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Constraining carbon gross fluxes with oxygen isotopes' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Oxygen isotopes in atmospheric carbon dioxide can be used to obtain a better understanding of biospheric carbon fluxes, which must be understood in order to predict vegetation and climate change in response to anthropogenic greenhouse forcing. The main objective of this proposal is therefore to improve understanding of carbon flow in the biosphere by enhancing a comprehensive global 3D model of the movement of stable oxygen isotopes in plants, soil and the atmosphere. This objective will be achieved by measuring unknown fractionation factors, and by improving descriptions of plant and soil processes, including processes that had previously been omitted, and incorporating complementary tracers in the existing model. The resulting model will be the most comprehensive description of oxygen isotopes in atmospheric carbon dioxide up-to-date, where complementary tracers constrict individual aspects of the isotope cycle. The model will strictly constrain gross biospheric carbon fluxes, allowing direct comparison between measured and modelled oxygen isotope ratios in atmospheric carbon dioxide. This isotope model will then be incorporated in an Earth Systems Model (ESM) currently being developed. This will allow further detailed studies of biosphere/hydrosphere, biosphe re/atmosphere and biosphere/climate interactions, as well as studies of human influences on the Earth climate system. The ability to track oxygen isotopes in the biosphere components of the ESM will substantially reduce the uncertainty in inferred carbon sources and sinks on scales ranging from regions to continents, thus greatly improving the ESM's predictions of climate change and climate variability.