RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unsteady effects in shock wave induced separation' (UFAST).

assistant: **Concept**

According to the need of the aeronautics industry the general aim of the UFAST project is  to foster experimental and theoretical work in the highly non-linear area of unsteady shock wave boundary layer interaction (SWBLI). Although in the past several E U projects were aiming at transonic/supersonic flows, the area of unsteady shock wave boundary layer interaction has not yet been treated. Moreover, experimental methods as well as numerical approaches have been improved considerably. The main stu dy cases, shock waves on wings/profiles, nozzle flows and inlet flows, will  serve as a sound basis for open questions posed by the aeronautics industry and can easily be  exploited to enable more complex applications to be tackled. In addition to these basic flow configurations control methods, synthetic jets, electro-hydrodynamic actuators, stream-wise  vortex generators and transpiration flow, will be investigated for controlling both interaction  and inherent flow unsteadiness. The interaction u nsteadiness is initiated and/or generated by SWBLI itself but often it is  destabilised by the outer flow field. Therefore, the response of shock wave and separation to  periodic excitations is of utmost importance and is included in the research program . Thus emphasis is placed on closely couple experiments and numerical investigations to  allow for feeding back numerical results to the experiments and vice versa for the sake of  identifying and overcoming weaknesses in both approaches. When using RANS/URANS and hybrid RANS-LES methods, UFAST will generate new  methods for turbulence modelling in particular for unsteady, shock dominated flow. Moreover, LES methods will be applied to deal with large coherent structures that govern SWBLI. This way, UFAST will investigate the range
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A holistic approach to bridge the gap between microsecond computer simulations and millisecond biological events' (MilliInMicro), addressing dissemination and exploitation.

assistant: **Impact**

Complete understanding of how complex biological objects operate and fulfill their cellular role requires at its core a detailed picture of the millisecond (ms) conformational transitions between functional states. Computational investigation of such ms–events is thwarted by our difficulty—and often impossibility—to identify and sample efficiently the relevant degrees of freedom at play, as well as the current limitation of all-atom molecular dynamics to the microsecond (μs) timescale on common computer architectures. Guided by concrete biological questions that experiment alone has hitherto proven unable to address, we propose a holistic approach to bridge affordable μs–computer simulations and ms–biological processes without the aid of a special-purpose supercomputer. To meet this grand theoretical challenge, we will associate two powerful developments to make the quantum leap, and open a breadth of applications, scaling up to very large biological objects, so far inaccessible to μs–timescale computer simulations. First, we will determine the reaction coordinate in an unprecedented combination of data- driven discovery of collective variables and advanced algorithms to find the minimum free-energy pathway that connects the end states of the conformational transition. Second, we will accelerate sampling along this pathway by associating ergodic schemes to a novel approach that maps complex free-energy landscapes significantly faster than its competitors. We will apply this methodology to a V1Vo–ATPase, a complete ATP–driven biological motor that converts over the ms–timescale the chemical energy of ATP hydrolysis into mechanical work, with minimalist dissipation. Beyond illuminating the allosteric pathways that underlie the conformational transition, atomic-level descr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Think tank for the collaboration on NEXt generation internet between EU-US'.

assistant: **Concept**

The Internet of the future should be more open, provide better services, more intelligence, greater involvement and participation. It needs to reflect the European values”. EU’s Next Generation Internet initiative is a key opportunity to rethink the way the Internet works today and develop a vision involving voices from across Europe, the US, and beyond, an Internet that embodies the values Europe holds dear, such as openness, inclusivity, transparency, privacy and cooperation. Thinking global, the NGI will be successful only if a worldwide consensus is found, enabling the internet a Human-centric process. To that end, collaboration between the US and the US, both area being strongly committed to develop the future of Internet, to shape a sustainable landscape for NGI developments. Indeed, the NGI initiative should design specific actions for policy collaboration, shared technology development and interaction between user-communities, with other initiatives in the world where parts of the NGI infrastructure are designed and deployed; and the US are one of the main places where such activities are held.Think NEXUS aims to reinforce EU-US collaboration, through its dedicated Think Tank, involving major stakeholders (researchers, entrepreneurs, policy makers) from both sides of the Atlantic on NGI-related thematics in three Focus Areas: Science and Technology, Innovation and Entrepreneurship and Policy. Its mission is to become an important and lasting entity, involving stakeholders and disseminating NGI visions in a collaborative approach for tackling NGI challenges, and benefit society at large. More specifically, Think NEXUS is expected to boost the strategic research, industrial partnerships and policy compliances among the respective communities of the NGI areas and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'PRODUCT CATALOGUES IN THE GLOBAL ENGINEERING NETWORK'.

assistant: **Concept**

PROCAT-GEN is part of the Global Engineering Network (GEN) initiative for the global electronic marketing of engineering products and services, concentrating on core competencies, market flexibility and the ability to exploit the best component technology. The project will focus on the specific needs of multimedia product catalogues and improving component supplier/user communication through their effective delivery on the information highway. Their typical requirements and uses will be documented so that, as a result of the main project phase, a complementary key component will enable GEN to deliver catalogues based on well-researched market needs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biomethylation and Biovolatilisation of Arsenic in Soils: Using Carbon and Hydrogen Isotopes to Unravel the Mechanisms and Pathways Involved' (BIOMETA).

assistant: **Concept**

Arsenic (As) is a ubiquitous element found in almost every environmental compartment. Moreover, inorganic As is a Class 1 non-threshold carcinogen and globally, millions of people are at risk, mainly through drinking tainted water which is also used to irrigate agricultural soils.As is found in soils in its inorganic form but also as organic As, mostly mono- and dimethylarsenic (MMA(V) and DMAV(V), (III) and (V) being the different oxidation states). The process leading to these compounds, biomethylation, is biological and it is still not fully understood. Moreover, it is linked to another remarkable mechanism: biovolatilisation. Microorganisms in soil transform inorganic As to much less toxic methylated compounds, mostly MMA(V) and DMA(V), producing as well reduced methylated compounds (MMA(III) and DMA(III)) which are even more toxic than inorganic As. Biovolatilisation leads to the production of four highly volatile As compounds (arsine, mono-, di- and trimethylarsine) and their toxicity is still highly discussed.Although the products are known,  only indirect evidence exists on the different possible pathways, which are still highly debated. We propose here to employ a dual isotope approach, using 2H and 13C labeled methyl groups, placed on different methylated As molecules, to unravel As biomethylation & biovolatilisation pathways. These compounds will be injected in As methylating bacteria, fungi & protozoa cultures and in soil microcosms. The resulting molecules (including volatiles) will be measured/traced using analytical speciation techniques such as cryotrapping & GC coupled with state of the art IRMS instruments.These experiments will shed light on processes that lead to an array of As molecules of varied toxicities and physico-chemical properties being rele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Immunotherapy of leukaemia using suicide gene transduced donor lymphocytes in the context of allogeneic bone marrow transplantation' (1994-1998).

assistant: **Innovation**

- To demonstrate1.1. the ability to transduce and select donor Iymphocytes in conditions required for a clinical study;1.2. the safety of genetically modified donor lymphocytes in the context of allo-BMT;1.3. the survival and immunocompetence of transduced donor lymphocytes in vivo;1.4. the in vivo selective elimination of transduced cells by ganciclovir treatment;1.5. the in vivo safety and efficacy of secondary infusions of transduced donor Iymphocytes after selective elimination of previously infused cells- To verify2.1 the effects of transduced cells on the incidence and severity of GvHD;2.2. ganciclovir response of GvHD secondary to the infusion of transduced donor cells;2.3. the impact of this strategy on leukemic relapse and overall disease-free survivalThe aim of the proposed project is to demonstrate the viability and benefits of the use of donor lymphocytes transduced with a suicide gene, to prevent and treat leukemic relapse occurring after allogeneic Bone Marrow Transplantation (allo-BMT). Allo-BMT is the treatment of choice for many patients with hematological malignancies. The therapeutic impact of allo-BMT is mainly mediated by an allogeneic immune mediated effect (graft versus leukemia-GvL) largely mediated by donor-derived T Iymphocytes. Unfortunately, the therapeutic benefits of allo-BMT are limited by a variety of complications including life-threatening infections and graft versus host disease (GvHD), also mediated by donor-derived T-lymphocytes. GvHD can be prevented by the removal of T lymphocytes from the donor marrow prior to infusion. However, T-cell depletion increases the incidence of graft rejection, reactivation of endogenous viral infections, and recurrence of disease, and does not result in an improvement in the disease free survival We pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Stereoelectronic control in supramolecular systems'.

assistant: **Objectives**

It is proposed to investigate, (i) by means of template-directed synthesis that is closely guided by structural studies in both the solution and solid states as well as (ii) by computational methods receptors based on interlocked molecular compounds containing Pi-donating and Pi-accepting aromatic recognition units. The aim of the research is to gain fundamental understanding as to how intermolecular stereoelectronic factors govern the strengths and geometries of binding of Pi-accepting aromatic substrates in selfassembled (3) catenanes containing a Pi-electron rich binding pocket. Through modification of the size and the geometry of this binding site, as well as by the variation of the Pi-donor and Pi-acceptor units, we hope to gain access to interlocked molecules capable of behaving as tunable synthetic molecular receptors. We hope to achieve insight into new ways of synthesising selective substrates binders and molecular switches with fascinating topological features.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Prospering without growth:  Science, Technology and Innovation in a post-growth era' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The feasibility and desirability of endless economic growth is increasingly being questioned by scholars and activists. While envisioning alternative economic models is key to assure the sustainability and wellbeing of present and future generations, few studies have analysed what might be the role of innovation in a post-growth era. Innovating has become the imperative for the survival and expansion of any form of organisation. But this innovate or die mania underpins assumptions  such as technological determinism and productivism - that neglect the socially constructed character of technological development, its politics and its capacity to enable just and equitable societies but also dystopian technocratic futures. This project posits that untangling innovation from growth is key to imagining a post-growth era. If growth is going to be unsustainable, we need new narratives for innovation that would accordingly also have to change and increase the scope of the innovation concept itself, beyond technology, into cultural and institutional change, and indeed social life and social order. Organizations  in particular capitalist enterprises - are the core of modern industrial societies but are also one of the places in which the discourse of growth is legitimised and constantly reproduced. However, they can also be the places in which people can start to build the capacity for developing alternatives to challenges the growth ideology. But how organizations would look like in a different paradigm, in a system that is not based on and doesnt not rely on endless growth? Under which conditions STI without growth would be able to flourish? What levels of technological complexity can we reach in a non-growing economy? What policies, infrastructures and organizational forms are n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Genetic and environmental determinants of melanoma: translation into behavioural change'.

assistant: **Objectives**

GenoMEL, formerly known as the Melanoma Genetics Consortium, has focused on the identification of familial high penetrance melanoma genes. The joint programme of research has been very successful in the identification of susceptibility genes and developing joint data collection for gene/environment interaction studies.In order to continue its proactive role, GenoMEL wishes to develop a multidisciplinary European platform, directed towards:1. developing shared resources and activities2. identification of new susceptibility genes and understanding the role of these genes in tumours3. investigation of genotype/phenotype interaction and gene/environment interaction for known susceptibility genes4. investigation of attitudes to risk of melanoma in Europe, and translation of that risk perception into behavioural change5. spreading excellence by creating a widely accessible web-based content management system (CMS) to address prevention, early detection, dealing with the diagnosis of melanoma and genetic counselling.Through GenoMEL's jointly executed research, groups will support the network's goal to maintain excellence in research, increase institutional integration and create an enduring structure of translational melanoma genetics research in Europe and other countries. European integration will enhance dialogue, disseminate expertise and resources, provide training and allow mobility of scientists within Europe. It is aimed to keep the network open and dynamic by adding new partners, especially in Eastern Europe where melanoma incidence rates may rise most precipitously in the near future, if the expected increase in wealth results in greater levels of sun exposure. There will be participation from four new European groups and others from Australia, the USA and Israel to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Artificial Language Evolution on Autonomous Robots'.

assistant: **Innovation**

This tightly integrated focused project aims at fundamental breakthroughs in understanding and synthesising the mechanisms achieving cognition and language. It engages in carefully controlled experiments in which autonomous humanoid robots self-organise rich conceptual frameworks and communication systems with similar features as those found in human languages. Language and cognition are seen as complex adaptive systems that are continuously shaped by the actions of their users.<br/><br/>The project takes a 'whole systems' approach and tackles the complete chain from embodiment and sensori-motor action to conceptualisation and language. Concept formation and language invention and acquisition are embedded in situated interactions. The inventory of concepts, the strategies for grounding them in the world, and action co-evolve with the emergent artificial languages. Next to the required physical and cognitive capacities of each robotic agent, we also focus on the complex systems phenomena that appear when a group of such agents starts to interact in a distributed fashion.<br/><br/>The machinery required for these experiments will heavily push the state-of-the-art in all relevant technologies, particularly robotics, concept formation, computational linguistics, and A.I. We need rich sensors, actuators and robust, real-time performance of vision and motor control subsystems. We need sophisticated constraint-based conceptualisation of the world and effective parsing and production systems. Above all we need to discover how these systems can build up their competence autonomously and remain adaptive to cope with changing environments.<br/><br/>The project's orientation towards robotic experimentation is complemented by a search for an encompassing framework in which we seek t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Extreme Food Risk Analytics' under Horizon Europe.

assistant: **Concept**

EFRA will explore how extreme data mining, aggregation and analytics may address major scientific, economic and societal challenges associated with the safety and quality of the food that European consumers eat. EFRA’s goals are: i) develop and test solutions to discover and distil food risk data from heterogeneous and dispersed/scarce data sources with minimal delay and appropriate format; ii) design relevant human aspects & interactions with users to measure usefulness for human risk prevention actions in real-world use-cases iii) demonstrate how solutions enable the development of trustworthy, accurate, green and fair AI systems for food risk prevention iv) achieve groundbreaking advances in performance and effectiveness of food risk data discovery, collection, mining, filtering, and processing; v) integrate relevant technologies (big data, IoT, AI) to foster links to food data innovator communities vi) position its contributions into the overall ecosystem of public & private stakeholders that share data, technology and infrastructure to ensure the safety and quality of food in Europe. To achieve these goals, EFRA will design, test, and deploy tools and undertake appropriate initiatives to facilitate their uptake, elicit feedback, and engage stakeholders. The EFRA tools are: (i) EFRA Data Hub, offering intelligent crawlers and data annotation & linking modules to search, mine, process, annotate, and link dispersed, multilingual, heterogeneous, and deep/hidden food safety data sources (ii) EFRA Analytics Powerhouse: offering modules running over a green cloud HPC that distil useful insights & signals from the EFRA Data Hub to train privacy-preserving, explainable, green food risk prediction AI models (iii) EFRA Data & Analytics Marketplace: A front-facing user-friendl