RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project '6G Ai-native integRated Ran-cOre netWorks' (6GARROW), addressing dissemination and exploitation.

assistant: **Impact**

This SNS international project fosters collaboration between the European Union (EU) and the Republic of Korea (ROK). AI-native radio access networks and integrated device-network approaches represent a paradigm shift in the field of wireless communication, offering unprecedented opportunities for innovation and optimization. By leveraging artificial intelligence (AI) technologies at the heart of radio access networks (RAN) and integrating devices seamlessly into network architectures, we can unlock new levels of efficiency, flexibility, and performance. Traditional approaches to wireless communication are often limited by static configurations and manual interventions, leading to suboptimal resource utilization and scalability challenges. In contrast, AI-native RAN and integrated device-network approaches empower networks to adapt dynamically to changing conditions, optimize resource allocation in real-time, and autonomously respond to diverse user demands and environmental factors. This transformative approach not only enhances the user experience by delivering higher throughput, lower latency, and improved reliability but also lays the foundation for realizing a diverse range of innovative services, including spatio-temporal, critical, compute-AI, omnipresent IoT, immersive communications, and global broadband services. Moreover, by fostering interoperability and collaboration between devices and networks, these approaches pave the way for seamless connectivity across heterogeneous environments, driving innovation and fostering new business models in the era of 6G and beyond. The project builds on the foundations of established EU-Korea research collaboration including 5G-CHAMPION project that demonstrated 5G technology in the 2018 Winter Olympics in PyeongChan, PriM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Assessing cardiac Contractility and Quantification of Underlying mechanisms In vitro via Response in Excitation-contraction coupling' (ACQUIRE), addressing dissemination and exploitation.

assistant: **Impact**

Academia and industry urgently needs reliable models to study heart failure and toxic effects of drugs on the heart. While new models based on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are now emerging, accurate readouts of cardiomyocyte function fall short of needs. Apart from improving the models biologically, more sensitive, informative and accurate readouts are needed to detect abnormal cardiomyocyte behaviour. Several tools have proven their ability to assess electrical changes or calcium handling in hiPSC-CMs, but they are typically incompatible with 3D tissue models and moreover, there is paucity of appropriate tools to quantify the most important function of myocardium: contraction. Our ERC Advanced Grant STEMCARDIOVASC entailed the development of improved tools for cardiac functionality. One of the most important bioassays developed as an outcome of STEMCARDIOVASC was the Triple Transient Measurement (TTM) System. The TTM System quantifies electrical activity, intracellular calcium flux and contractility simultaneously and is our answer to the challenge of pharma in understanding when and how drugs or diseases affect cardiac contractility using hiPSC-CM models. In this ERC Proof of Concept project “ACQUIRE”, we strive to bring the TTM to a commercial applicable service, and later product. To reach this goal we have set out four aims to come to a Minimum Viable Product: i) increase the flexibility of the system to accommodate a larger variety of optical probes, ii) increase the throughput of the system to compete with current measurement systems, iii) increase user friendliness by integrating software modules for running and analysing measurements and iv) define a route for commercialisation. Resulting from ""ACQUIRE"" the TTM System
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative Distributed Electrical Network' to be submitted under Horizon 2020.

assistant: **Abstract**

With the introduction of the more electric aircraft greater emphasis is placed on the power generation and  distribution architecture as a result of increased power demands and higher efficiency needs, as well as the interest in using electrical power for more flight critical applications. Together with the steady drive for reduced weight, increased reliability and reduced maintenance, this leads to the requirement for new approaches for the aircraft electrical supply generation and distribution, managed intelligently to maximise efficiency and ensure safe aircraft operation under all conditions.  The prime aim of the project is the design, development and test of an ‘Innovative Primary & Secondary Electrical Distribution Network for Regional A/C’ based upon state of the art power semiconductors and enhanced electrical energy management (E2-EM). The EPGDS to be designed comprising 2 Primary Power Centres - PPC, 4 Secondary Distribution Units - SDU, 2 AC/DC converters, solid-state based contactor/breakers - SSPC and externally provided System Supervisor & DC/DC converter interface between HV & LV primary bus bars. The system will be designed to interface to the REG Iron Bird facilities.The design of each LRU will be based upon the use of state of the art power semiconductor devices, innovative circuit topologies and embedded intelligence. A foundation stone of the EPGDS system is the effective modelling of each of the LRU’s and the overall system to enable the investigation of diverse operating conditions, permit verification of correct functionality and highlight any deficiencies at an early stage. In addition it will permit the use of automatic code generation of each LRU embedded controller.All designs will take into account the specification requirements for avionic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Pathways, Memory and Information Processing in Matter'.

assistant: **Concept**

Imagine squeezing a crumpled plastic sheet – what is its response? For complex materials – crumpled sheets, granular media, glassy materials – tiny forces already cause a nonlinear response, associated with hopping in the energy landscape, for which we lack a coherent description. The central tenet of this proposal is that this hopping allows complex materials to process information. I propose to understand and unlock the full potential of such complex materials. Central questions are:- How can we describe their nonlinear response?- What are the computational capabilities of complex matter?- Can we create materials for targeted computations?To answer these questions, I will subject macro-scale complex matter to sequentially and spatially patterned driving forces (information input), and observe the sequential response (information output). The responses to multiple forcings form an intricate web of linked pathways, which can be represented in a graph that I interpret as encoding a sequential computation. This is the central link between driving, pathways and information, which allows me to probe the algorithmic capabilities of complex materials. Recent breakthroughs in my group have brought experimental access, modelling and design of pathways within reach. In this proposal, I will investigate these pathways and will develop strategies to create algorithmic matter, using a combination of disordered – crumpling – sheets and carefully designed mechanical metamaterials; I will develop theoretical models for both. Just like a focus on the architecture of complex matter has revolutionized our view of their linear response and gave birth to mechanical metamaterials, a focus on their pathways will revolutionize our understanding of their nonlinear response and opens the door t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Directed and three-dimensional placement of continuous fibres with the direction of forces enabling a significant reduction of costs and weight in carbon fibre components' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Following the trends towards energy and resource efficiency, lightweight construction is more and more in the focus of attention, especially in the automotive, aerospace and engineering markets. The main problem, however, is the still existing stress ratio between costs, weight and strength of the components. While a standardised production of simple composites is already possible, the manufacturing of highly stressed structural components based on carbon fibre reinforced plastics, which are becoming more and more market relevant, still poses a major challenge. Although it is possible to manufacture composites that show high specific strength and stiffness, this is linked to very high production costs and so far only possible for unidirectional fibres. However, for most structural components this is not sufficient, requiring the specific use ofreinforcements or additional fibre systems. This is mostly related to  additional manual work, leading to both, lower production speed and higher overall costs. KEIM has developed a prototype for the three-dimensional placement of fibres in the direction of the force for the creation of the preform that is then finalised by using the hot-RTM process. The prototype is based on a robot that uses previously determined measurement data to perfectly place the fibres with regards to material usage, weight and stiffness, creating a three-dimensional preform with perfect properties. This preform is then introduced into the hot-RTM process in order to create highly stressed structural components. The functionality has already been tested thoroughly and demonstrated in an industrial environment. In addition, the process has been patented, securing the freedom to operate. In the feasibility study, the economic and technical validation of pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Assembly and maintenance of a co-regulated chromosomal compartment'.

assistant: **Concept**

Eukaryotic nuclei are organised into functional compartments, – local microenvironments that are enriched in certain molecules or biochemical activities and therefore specify localised functional outputs. Our study seeks to unveil fundamental principles of co-regulation of genes in a chromo¬somal compartment and the preconditions for homeostasis of such a compartment in the dynamic nuclear environment.The dosage-compensated X chromosome of male Drosophila flies satisfies the criteria for a functional com¬partment. It is rendered structurally distinct from all other chromosomes by association of a regulatory ribonucleoprotein ‘Dosage Compensation Complex’ (DCC), enrichment of histone modifications and global decondensation. As a result, most genes on the X chromosome are co-ordinately activated. Autosomal genes inserted into the X acquire X-chromosomal features and are subject to the X-specific regulation.We seek to uncover the molecular principles that initiate, establish and maintain the dosage-compensated chromosome. We will follow the kinetics of DCC assembly and the timing of association with different types of chromosomal targets in nuclei with high spatial resolution afforded by sub-wavelength microscopy and deep sequencing of DNA binding sites. We will characterise DCC sub-complexes with respect to their roles as kinetic assembly intermediates or as representations of local, functional heterogeneity. We will evaluate the roles of a DCC- novel ubiquitin ligase activity for homeostasis.Crucial to the recruitment of the DCC and its distribution to target genes are non-coding roX RNAs that are transcribed from the X. We will determine the secondary structure ‘signatures’ of roX RNAs in vitro and determine the binding sites of the protein subunits in vivo. By biochemi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Discovery and characterization of functional disordered regions and the genes involved in their regulation through next generation sequencing' (IdrSeq) under Horizon 2020.

assistant: **Objectives**

A large fraction of any eukaryotic genome (>40%) encodes protein segments that do not adopt a defined tertiary structure. These proteins or regions are called intrinsically disordered proteins/regions (IDPs/IDRs). IDRs are enriched in critical functions such as transcription and signaling, and have been linked with numerous diseases including neurodegeneration and cancer. In contrast to structured regions, the molecular principles behind the sequence-function relationship of IDRs remain poorly understood.We propose to identify functional IDRs and discover genes that regulate their function using yeast as a cellular model. We will develop and apply a targeted, high-throughput approach called IdrSeq. This technology exploits next generation sequencing to simultaneously assay vast libraries of sequences (~millions) that code for IDRs by coupling IDR sequence (genotype) to a selectable function (phenotype) and identifying functional variants through a selection experiment. Specifically, using IdrSeq, we aim to identify and characterize IDRs in a cellular context that can(Aim 1) activate transcription, and discover genes that regulate IDR mediated transcription (Aim 2) influence protein stability, and discover genes that regulate IDR mediated half-life(Aim 3) form higher-order assemblies and discover genes that regulate assembly formation The unique feature of this proposal is its integrative vision of synthetic & systems biology, structural biology, cell biology, genetics, experiments and computation to establish a discovery platform to study IDRs in a cellular context. Since IdrSeq is modular and scalable, it can be readily extended to investigate a broad range of IDR functions, and adapted to other organisms. Elucidating the principles of sequence-function-gene relationsh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Constructing an Artificial Enzyme for Olefin Metathesis' (AEOM).

assistant: **Concept**

The introduction of stable and selective catalysts for olefin metathesis (OM) has considerably simplified the construction of double bonds. Herein we propose to tackle two areas of the OM reaction that have received little attention. First, we will address selectivity problems in an important type of OM reaction: metathesis cross-coupling or simply cross metathesis (CM). Second, we will examine the potential applications of OM in chemical biology. OM has no biological counterpart and therefore it may be possible to do metathesis chemistry in the biological milieu without affecting endogenous cellular processes. Although seemingly incongruent goals, both are attainable within the framework of this proposal because of the special nature of the metathesis catalysts we propose to develop: artificial metathesis enzymes. We propose to endow a protein with an OM active-site. A highly modular proteinaceous secondary ligand sphere will allow the use of recombinant molecular biology techniques to generate new ligands for the metathesis catalyst; in this way a large number of catalyst structures can be generated in a short time. The family of catalysts can then be tested in metathesis reactions that are difficult to perform selectively, such as cross metathesis. A hallmark of enzymes is the exquisite selectivity they often display for their substrate, and we believe this can be harnessed in the context of OM to solve many of the current selectivity problems. A second focus of the research will be the application of the metathesis enzyme as a tool for chemical biology. Since there is no biological analogue of OM, it may be possible to use metathesis to tag biomolecules in vivo. Moreover, a protein derived ligand would allow for selective localization in vivo through the selection o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Intelligent commercial refridgerator of the future'.

assistant: **Concept**

The target of the BrainFridge project is to design, develop, integrate, demonstrate and validate a novel product-service in the area of Intelligent Commercial Refrigerators or Freezers. The BrainFridge product-service will incorporate a number of functionalities that will enable optimised operation and added value services through its entire lifecycle. In summary the main BrainFridge product-service objectives are to introduce simple principles of supply Chain Management, by automating the ordering/re-ordering procedures and centralised stock management, to enable the automatic display of promotional messages of audiovisual and textual content on active displays mounted on the intelligent fridges, to embed in the intelligent fridge a fully functional mobile and local networking communications unit, and to introduce a number of energy saving innovations in the cooling cycle and the peripheral technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BRONTE: Biological processes Re-descriptions by Ontology Expressions' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The project concentrates on the development of techniques for the analysis of time (and other parameters) dependent analysis of high volume biological data, e.g. micro-array experiments. The analysis thus obtained can be used to reconstruct models of various biological systems. The project ties in statistical analysis of time course data with the growing number of ontological" annotations of genes and gene products.In particular the project will target the Gene Ontology as a suitable substrate to produce descriptions of a biological system time dependent activity. As a secondary, yet very important goal, the project will provide a set of tools and techniques that can be used to confront and compare different ontologies by grounding them in the measured data of a number of wet-lab experiments."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Utilization of H2O2 in Transpiration Cooling System for Active Heat Protection and Implementation of Thermal Decomposition for Catalyst Free H2O2/Kerosene Bipropellant Aerospike Rocket Engine' (HYPER-CAT).

assistant: **Innovation**

The rapid increase in the number of small satellites in recent years has dramatically boosted the probability of orbital collisions that inevitably create space debris. To preserve the orbit's sustainability, a storable/stable, environmentally-friendly, highly efficient, and compact propulsion system is required to be mounted on the satellites. Hydrogen Peroxide (H2O2) and aerospike engines are promising candidates if the major flaws are solved: catalyst performance degradation due to stabilizer poisoning and extreme thermal loads at the spike structure. In this proposal, I want to test the novel concept of utilizing the thermal decomposition process of H2O2 by turning the aerospike engine's cooling challenges into an advantage. Liquid H2O2 adsorbs heat from the structure convectively, then vaporizes/decomposes to create gas layers to protect the structure from the direct contact of the combustion gas. The thermal decomposition of H2O2 eliminates the use of catalysts. Overall, the concept offers a unique approach to an efficient, compact, and durable propulsion system for small satellites.In the project, liquid H2O2 will be injected into the H2O2/Kerosene staged-combustion vitiated-air heater through the additive manufactured porous metallic wall (Fraunhofer IWS). Testing in various conditions, heat flux/temperature/pressure will be measured directly. Key variables (Da and H*) can't be directly measured. Hence, the mathematical model will be formulated to derive these variables under given conditions. The model will be validated by comparing the mono/bipropellant flame front locations between the simulations/experiments. Then, I will generate a low-order modeling tool that can predict the cooling performance and combustion efficiency based on the data and the model. The