RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Empowering root-targeted strategies to minimize abiotic stress impacts on horticultural crops'.

assistant: **Innovation**

ROOTOPOWER aims to develop a multidisciplinary suite of new tools targeted to the root system to enhance agronomic stability and sustainability of dicotyledonous crops under multiple and combined abiotic stresses: salinity, water stress, soil compaction and low fertilizer (N, P, K) input. Central to our approach is the use of tomato as a model species since it can be very easily grafted (usual commercial practise). This surgical technique allows precise assessment of the effect of altering root traits on crop performance independently of any shoot traits, since the scion (shoot) is constant. This project will analyze and exploit the natural genetic variability existing in a recombinant inbred line population (RIL) from a cross between Solanum lycopersicum and S. pimpinellifolium and other selected mutants and functional lines (used as rootstocks) for their performance under multiple abiotic stresses and for their biotic interaction with natural soil microorganisms (mycorrhiza and rhizobacteria). The key research challenges are: (i) to identify stress-resistant root systems and rhizosphere microorganisms (and their synergisms) for enhanced resistance to individual and combined abiotic stresses; and (ii) to understanding the underlying genetic and physiological mechanisms, which are potentially fundamental to all crops, and readily exploited in dicotyledonous crops. This project will first identify genetic variation and quantitative trait loci (QTL) that allow tomato roots to confer crop resistance to a range of abiotic stresses, alone or in association with arbuscular mycorrhizal fungi (AMF) and/or plant growth promoting rhizobacteria (PGPR). This approach will establish the physiological and signalling processes conferred by key QTLs, and identify candidates for the cau
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Numerical modelling of failure development within TBC systems' (2002-2006).

assistant: **Concept**

The scientific objective of the project is a development of new methods for a prediction of service life times of a single crystal Ni-based super-alloy used in the design of heavy industrial gas turbines. Under operation conditions turbine blades experience complex loading, combined with the existence of residual stresses and oxidation processes. The improvements in increasing the efficiency of gas turbines have been partially achieved by applying thermal barrier coatings (TBCs) on turbine blades. However, the mechanisms leading to failure and the parameters limiting coating lifetime have not been fully revealed so far. Finite element simulations of failure development within TBCs will be performed. They are aimed to be a continuation of works performed by Dr Bialas during his Marie Curie Intra-Fellowship in the Research Centre Juelich (FZJ).In this context the project's goal is also to further promote an on-going co-operation between FZJ and the Institute of Fundamental Technological Research (IFTR), Warsa w, dr Bialas' mother institution in Poland. The project will enable an interdisciplinary co-operation between theoretically oriented structural mechanics and the experimentally oriented materials science at FZJ and thus, contribute to an increase of scientific excellence in Europe. It will also help to create a group of researchers at IFTR working with thin films technologies and to adapt the methods learned by Dr Bialas during his fellowship to other engineering topics, which are generally connected to interfacial damage problems. Mechanical modelling of constituents of TBC systems will be performed with the main goal of a further development of the TBC failure model based on the cohesive zone concept. Anisotropic and time dependent mechanical response of C MSX-4 Ni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Experimental vaccinology, revealing unnatural signatures of protection by repeat controlled human schistosome infection.' (ReCHISVac) under Horizon Europe.

assistant: **Objectives**

Schistosomiasis is a neglected tropical disease afflicting over 200 million people and causing 300,000 deaths in Africa alone. Whilst infections can be cleared with schistosomocidal drugs, individuals will become rapidly re-infected upon exposure to contaminated water. Partial immunity only develops naturally only after decades of constant infection, and there is no vaccine. Previous schistosome vaccine studies have been flawed, due to a lack of understanding of what constitutes a protective immune response, focus on single antigen targets, and a lack of pharmaceutical industry support or expertise for development.Here, I propose to use unique samples from repeat Schistosoma mansoni controlled human infection (Sm-CHI) models to reveal novel antigens and corresponding cellular and cytokine responses that are protective against schistosomiasis. To evaluate how well this protective signature will translate to endemic countries, matched analyses will be performed in samples from naturally schistosome infected Ugandan individuals. Antigen-specific antibody and cellular immunology data will be combined utilising bioinformatic tools to reveal a signature of multiple antigens and immune responses associated with protection from schistosomiasis. Next, in a non-academic placement at Batavia Biosciences, I will develop a pre-clinical development plan to translate the identified protective immune signature into an effective vaccine against human schistosomiasis. This fellowship will form the basis of my future career development, to become an independent researcher in the field of schistosome vaccinology.


**Keywords:** Schistosomiasis, controlled human infection, antigen discovery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Pathways of pension reform in Europe; Sweden, Italy, Poland and the UK in comparative perspective, since c.1990'.

assistant: **Objectives**

This research project is dedicated to the study of pathways of pension reform in Europe. It concentrates on four countries (Sweden, Italy, Poland and the UK), which were deliberately selected to encompass the variety of welfare regimes existing across the continent, as well as the main types of pension reforms that occurred over past decade. The project proposes the application of a new conceptual and methodological framework, centred on the classification of pension systems and reforms according to the logic of distribution of rights and resources underpinning each institutional arrangement.The framework was conceived to capture the dynamics of pension regimes by systematically evaluating the impacts of changes in the rules regulating the distribution of pension entitlements, costs and benefits across social groups and generations. After a detailed study of pension rules, the project will locate pension systems in each country within the classificatory framework and evaluate how individual national systems changed over time.This will facilitate a quantitative assessment of the distributional impacts of pension reform by comparing changes in the lifecycle gains and losses of individuals belonging to different birth cohorts, gender and income groups under each pension regime. By combining the incidence of costs, benefits, and eligibility conditions over the entire lifespan of a number of stylised individuals, the research will estimate the intra and inter-generational transfers operated by the pension system and the changes in the amount and direction of these transfers resulting from pension reform. The findings of the research will enhance comparative analysis on the nature and impacts of pension reform across Europe, will contribute to understanding the process of con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dissecting Protective and Pathogenic Long-lasting Humoral Immunity' (DIPP-IMMUNE), addressing dissemination and exploitation.

assistant: **Impact**

Long term humoral immunity essentially relies on two types of cells exported from germinal centers (GC): plasma cells (PCs), which secrete antibodies, and memory B cells (MBCs). Both subsets of cells can survive for decades in humans, being responsible for the extended protection afforded by the most successful vaccines but also therapeutic failures in the context of B-cell mediated autoimmune diseases. Which cells are selected and what drives them to become long-lived, in normal or pathological conditions, remains a central question in immunology. Studies in humans have so far been curtailed by the limited amount of material available and the lack of longitudinal access to lymphoid organs. This proposal aims to address three intertwined questions for understanding the selection mechanisms underlying protective and pathogenic long-lived humoral immunity:  1. What are the cellular and molecular mechanisms driving the contraction of the MBC response in a vaccine/infectious setting? 2. Do PCs targeting a self-antigen or a vaccine/viral antigen differ in their selection, transcriptomic profile and maintenance? 3. What drives effective/defective self-reactivity purging in vaccine and pathogenic GC-dependent antibody repertoire? To tackle these questions, we have garnered unique access to key lymphoid tissues (spleen and bone marrow) involved in the initiation and long-term maintenance of the immune response from vaccinated donors and patients with a prototypic B cell-mediated autoimmune disease (immune thrombocytopenia, ITP). We believe this set of samples puts us in an ideal position, combining innovative and integrated single cell experimental approaches, to perform an in depth functional analysis of viral- and self-antigen-specific GC, MBCs and PCs and further advance our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Becoming me: how does the infant brain construct a self?' (SELFiE), addressing dissemination and exploitation.

assistant: **Impact**

Our capacity for self-awareness is often considered a defining feature of human consciousness and in adulthood allows us to imagine how others see us, recollect our past and contemplate our future. Our work has shown that in infancy, the emergence of a self-representation profoundly changes developing cognition. Yet, there are currently no mechanistic accounts of how it could develop, and empirical investigation within contemporary developmental science is surprisingly absent. In the current proposal, I put forward the first mechanistic account of the development of a self-representation, drawing upon recent data from cognitive neuroscience. This new account articulates a biological foundation that captures the idea that it is in detecting oneself as the target of another person’s attention that a concept of self emerges. I propose a pathway through which caregiver communicative cues towards infants – particularly direct gaze – give rise to a belonging to the body feeling state via their modulating effect on the heartbeat and its afferent cortical representation. Motivated by a bias to seek the targets of others’ gaze, a concept of self emerges from filling a placeholder target with this feeling state. This theory will be tested in 4 interlinked projects. Project 1 examines the longitudinal relationship between early interoception and a conceptual self-representation; Project 2 tests the novel hypothesis that direct gaze alerts infants to their interoceptive signals and Project 3 builds on this to test the claim that early in life, infants encode direct gaze as 'about me' which then fosters the inclusion of new self-related events in a reinforcing loop. Project 4 adds a crucial cross-cultural comparison capitalizing on natural variability in caregiving to test the model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'International, interdisciplinary PhD-program of the Centre for Systems Neuroscience Hannover (ZSN)' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Neuroscience has become the leading biomedical research field in this century. In this rapidly evolving field it is important to stress a multidisciplinary, systemic approach in order to develop therapies for neurological and mental disorders of great public interest. There is a fundamental lack of suchlike trained neuroscientists in Europe today. The Centre for Systems Neuroscience (ZSN) Hannover, established by the Hannover Medical School, the University of Veterinary Medicine Hannover, the Hannover University and Hannover University of Music and Theatre, focuses on multidisciplinary systems neuroscience to strengthen overlapping areas of basic and clinical research.The ZSN covers all modern methods in basic and clinical research including highly innovative techniques. Cooperating veterinarians have great expertise concerning genetic mutations in animals serving as animal models for human diseases. Its interdisciplinary approach has proven to be a promising way to strike at the root of neurological disorders and to analyse complex systems functions and their restoration. The ZSN uses its rewarding platform to provide highly needed PhD-training for outstanding graduates of relevant life sciences disciplines or subjects.In the 3-year-program PhD-students will gain broad neuro-scientific knowledge from bench to bedside and develop valuable complementary skills. Since the risk of premature specialization and the loss of interdisciplinary approaches is particularly acute in neuroscience, the project meets the needs to prepare early stage scientists for future tasks in this research field of vital significance for public health and the European competitiveness concerning research and economy. The project will provide 10 fellows with scientific and complementary s kills need
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Reconstructing abrupt Changes in Chemistry and Circulation of the Equatorial Atlantic Ocean: Implications for global Climate and deep-water Habitats' (CACH).

assistant: **Concept**

Ice-core records show that glacials had lower atmospheric pCO2 and cooler temperatures than today and that the last deglaciation was punctuated by large, abrupt millennial-scale climate events. Explaining the mechanism controlling these oscillations remains an outstanding puzzle.  The ocean is a key player, and the Atlantic is particularly dynamic as it transports heat, carbon and nutrients across the equator. This project proposes to consolidate my research through a focused study of present and past ocean chemistry in the Equatorial Atlantic and to assess the impact of ocean chemistry on fragile deep-sea ecosystems. Despite decades of research there are distinct gaps in our knowledge of the history of the deep and intermediate ocean. Major hurdles include access to suitable archives, development of geochemical proxies and analyses that are sufficiently precise to test climate hypotheses. Through a combination of ship board field work, modern calibrations and cutting-edge geochemical analyses this project will produce samples and data that address each of these gaps. A particular focus will be on using the skeletons of deep-sea corals. Research using deep-sea corals as climate archives, and indeed research into their habitats, environmental controls and potential threats to their survival are still fields in their infancy. The expense and logistics of working in the deep ocean, the complexity of the ecosystem and the biogeochemistry of the coral skeletons have all proved to be significant challenges. The potential payoffs of high-resolution, dateable archives, however, make the effort worthwhile. There have been no studies that attempt to match up co-located deep-sea coral, seawater and sediment samples in a single program, so this would be the first directed study of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Lightweight, composite friction brake systems', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Metal Matrix Composites (MMC) are now being exploited in some high volume (e.g. electronics packaging) and specialist (e.g. motor sport and cycle frames) applications. Major automotive applications the subject of intensive interest from materials suppliers (due to potential sales volumes) through to OEM's (due to the potential benefits of weight saving). The technical keys to exploitation of this family of MMC (ceramic particulate in aluminium-based matrix) in friction brake applications include temperature dependent strength, tribological performance, thermal conductivity and heat capacity with weight saving potential. For friction component applications the MMC formulation and processing with the development of a tailored counterface (pad) and where appropriate, thermal barrier coatings represent a complex and poorly understood system The aim of this project is thus to provide the basic rules of the game" for this emerging technical area to enable wider exploitation within the automotive sector."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DNA Breaks Shape Neural Genome Heterogeneity' under Horizon 2020.

assistant: **Concept**

Neural progenitor cells undergo tens of thousands of cell divisions to generate the 80 billion neurons in a human brain. In neural progenitor cells, replication stress can lead to recurrent DNA break clusters (RDCs). Joining of two RDC breaks may introduce somatic genomic diversity. On the other hand, unbalanced genomic mosaicism in neural progenitor cells may lead to brain cancer and neuropsychiatric disorders. This proposal will test whether cell-autonomous DNA lesions that accumulate during rapid progenitor division contribute to the genetic heterogeneity found across neuronal cell populations.  Aim 1 will elucidate how replication stress drives recurrent break clusters in the neural progenitor cell genome. We will evaluate whether chromatin loop extrusion mechanistically contributes to breakage repairs, and thus helps shape genomic structure variations. Aim 2 will quantify the extent and impact of tissue-specific recurrent break clusters in the embryonic brain. I will create a mouse model to identify DNA breaks in temporal and cell-type-specific manner across the entire population of neuronal progenitor cells.  Aim 3 will evaluate whether replicative stress drives the recurrent genomic alteration in the RDC-containing gene during embryonic neurogenesis. We will investigate one of the RDC-containing gene Neurexin 1, where deletion or truncation results in neurological disorders. By combining a powerful in vitro cell line-based tool, versatile in vivo mouse models, and cutting-edge multi-omics approaches, we will uncover the mechanisms that are critical to the fields of genomics and developmental neuroscience and may also provide valuable new insights into neuropsychiatric disorders and tumor biology.


**Keywords:** Genome heterogeneity, neural stem cell, common frag