RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'productive Green Infrastructure for post-industrial urban regeneration' to be submitted under Horizon 2020.

assistant: **Abstract**

For proGIreg three front-runner cities (Dortmund (DE); Turin (IT); Zagreb (HR))will create Living Labs in urban areas which face the challenge of post-industrial regeneration. These areas suffer from social and economic disadvantages, inequality and related crime and security problems. They lack quality greenspaces, have a negative impact on human health and wellbeing and are more vulnerable to the effects of climate change. Going beyond the current state-of-the-art with Green Infrastructure as a one-off state intervention, the proGIreg Living Labs will develop NBS which are citizen owned and co-developed by state, market and civil society stakeholders. Innovation will take place on the technical level through the NBS deployments, on the social level through co-designing, co-creating and co-implementing NBS with local communities and on the economic level through combining NBS with market-ready business models. Four follower cities in Eastern and Southern Europe (Cascais PT, Cluj-Napoca RO, Piraeus GR, Zenica BA) will be co-steering the research process to assure replicability and adaptability to their local context resulting in urban plans for NBS deployment. The NBS to be tested i.a. include: regenerating industrial soils biotic compounds, creating community-based urban agriculture and aquaponics and making renatured river corridors accessible for local residents.Scientific assessment and monitoring results from the Living Labs will be made available on the EU NBS platforms OPPLA and THINKNATURE and will contribute to the European reference framework for NBS. Global impact will be achieved by a training programme for cooperative planning, implementation and management of NBS. It will be provided by partners from the cities, SMEs and universities involved. Training eve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'LATENT TUBERCULOSIS: New tools for the detection and clearance of dormant Mycobacterium tuberculosis'.

assistant: **Concept**

Although the definition of latency under a clinical point of view seems clear, the bacterial biology behind that clinical situation remains poorly understood. While dormant, the tubercle bacilli are considered to be under non-replicating (NR) stage. In such a condition, bacilli are not only difficult to be detected but also refractory to the standard treatments avoiding their clearance from the infected tissues. The proposal has been built with the intend of providing tools to understand the bacterial mechanisms that leads to metabolic stage of M. tuberculosis during dormancy as the basis of sorting out the detection and treatment of latent infection. Several models of analysis have been developed trying to characterize dormant tubercle bacilli. Those models are ranging from in vitro conditions, such as hypoxia or starvation, to in vivo analysis, such as the animal model. We propose not only to study a complete range of those previously tested conditions, but also checking some other putative newly described, such as the recently described adipocytes ex vivo model, the new developments of the classical model of hypoxia, and the use of guinea-pigs as more adequate animal model of latent infection. Moreover, a set of drug combinations will be applied to determine their capability of clearance of the bacterial load. Due to its central role in the bacterial metabolism and growth we will analyze the non-replicating stage of the M. tuberculosis bacilli by determining the pre-rRNA synthesis. Finally, the cellular and tissue distribution of dormant bacilli will be also tested during in vivo latent infection both in the animal model and in clinical human samples. Research on the metabolic conditions of the dormant bacilli inside hosts, will provide important and invaluable insig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Intelligent Collections of Food Legumes Genetic Resources for European Agrofood Systems'.

assistant: **Concept**

INCREASE will enhance the management and use of Genetic Resources on food legumes, which are crucial for sustainability, food security and human health, as recognized by the new European Protein plan for the innovation of this sector in Europe. To meet this challenge INCREASE will expand the utilisation of food legumes Genetic Resources targeting users’ needs in terms of accessibility, quality and quantity of information available. INCREASE, working with four important food legumes (chickpea, common bean, lentil, lupin) with significant value for the innovation of EU agriculture and food industry, will be based on four pillars:i) innovative data management solutions to develop gold standards for data sharing and integration into the central infrastructure, with decentralised data input, defined methodologies and best practices for exploitation of the novel information produced as well as the development of user friendly visualization tools;ii) developing novel tools and principles for germplasm management, based on the development of “Intelligent Collections” as a set of nested core collections of different sizes representing the entire diversity of each crop;iii) adoption of cutting-edge technologies for genotyping and phenotyping combined with the potential of Artificial Intelligence focusing on traits of interest for users;iv) international effort with the involvement of non-European partners and international organization to expand the scope and ambition of INCREASE, by facilitating the integration of available data and available Genetic Resources for European users.We will develop a citizen-science experiment, primarily aimed at dissemination of the project to stakeholders and citizens.Overall, INCREASE will strengthen Europe in the field of legumes Genetic Resourc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plasticity of nuclear cycling in response to the environment' (PCNE) under Horizon Europe.

assistant: **Objectives**

The traditional view of proliferation in eukaryotic cells maintains that genome duplication is followed by cellular division into two new daughter cells, each containing its own nucleus. Organisms have evolved diverse strategies to accomplish this feat efficiently whilst acted upon by different selection pressures, some of which alter the mode of proliferation altogether. Strikingly, several organisms across the tree of life have evolved to utilize the multiplication of genetic material without the generation of new daughter cells as a successful replicative strategy. Although the nuclei reside in a shared cytoplasm, the dynamics of the nuclear cycles of multinucleate cells vary across organisms, from synchronicity, such as in the Drosophila embryo, to asynchronous replication as in the filamentous fungi Ashbya gossypii. While the fast, synchronized divisions in developing Drosophila embryos are hypothesized to benefit growth speeds, asynchronous divisions are hypothesized to balance replication speed with resource availability. While it is evident that the efficient use of resources for regulating the cell cycle control network is fundamental for survival and adaptation to the environment, the factors and molecular mechanisms regulating autonomous nuclear cycles in multinucleate cells are largely unknown. Using a combination of multiplexed spatial transcriptomics, classic cell biology approaches, high-resolution imaging, and molecular genetics, the proposed project will elucidate the extent to which the environment influences nuclear cycling in two evolutionarily distant eukaryotes, the free-living slime mold, Physarum polycephalum and the intracellular parasite, Plasmodium falciparum.


**Keywords:** Protist,  Apicomplexa,  evolutionary cell biology,  Physarum polycep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploring topological matter with atomic Dysprosium' (TOPODY), addressing dissemination and exploitation.

assistant: **Impact**

Recently, topology stepped in an increasing number of areas in physics, including via the concept of topological phases of matter. In strongly interacting systems, topological phases may exhibit intricate quantum entanglement between their constituents, leading to fascinating physical properties, such as the emergence of anyons. Since the discovery of fractional quantum Hall states in 1982, the scientific community is awaiting further experimental advances: new types of strongly correlated states, observation/manipulation of anyons. In this field, ultracold atoms promise novel approaches with a specific degree of control. Yet, despite the recent creation of weakly interacting topological states with atomic gases, reaching the strongly correlated regime, with long-range quantum entanglement, remains an open challenge.In TOPODY, I will use a novel approach to produce strongly correlated topological states with microscopic samples of atomic Dysprosium. The envisioned laboratory experiment will combine state-of-the-art techniques, such as single-atom detection or laser-induced spin-orbit coupling. It will allow preparing quantum gases subjected to artificial gauge fields beyond the previously accessible regimes. The project will focus on realizing two paradigmatic physical systems – the Laughlin state and a topological superfluid. 1. We will create the Laughlin state by injecting a controlled amount of angular momentum using optical transitions with finely-shaped laser beams. We will infer distinctive features of the Laughlin state – incompressibility and atom anti-bunching – from the distribution of atom positions. 2. We will produce strongly interacting Fermi gases in one dimension and subjected to a spin-orbit coupling, leading to a topological superfluid state. The topo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced data management and informatics for the  optimum operation and control of wastewater treatment plants' in the context of a Seventh Framework call.

assistant: **Objectives**

Nowadays most of the EU countries treat practically the totality of the volume of urban waste water (WW) generated. However, a deep look at the performance of most of the existing wastewater treatment facilities (WWTP) evidences that significant steps forward can still be given in terms of effluent quality, process robustness and operational costs.One of the main technical limitations for optimizing plant operation some years ago was the lack of reliable measuring devices. At present, new and more reliable on-line sensors are available and the main limitation for the optimal operation of WWTPs is, clearly, the great difficulty to properly manage all the heterogeneous, incomplete and, sometimes inconsistent data of the WWTPs. WWTPs daily manage thousands of data from all points of the plant. The likelihood that data errors and/or faults occur has consequently highly increased. Also, unexpected situations occurring in the plants make sensors not fully reliable yet sending incorrect data to the data management systems. Using these data for real-time operation and control activities could lead to a drastic deterioration of the wastewater treatment efficiency.The appropriate processing and management of the data available in a WWTP nowadays exceed the capacity of the staff of the WWTP, limiting the use of the information available for diagnosis and operation tasks. Advanced on-line data fault detection and monitoring tools could alert operators from sensors showing unrealistic or incorrect data whereas, real-time data processing and adequation tools could make data more reliable.Project DIAMOND aims to achieve a model of excellence in the management of wastewater treatment systems by addressing the design, development, implementation and validation of new advanced data manag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Policy dialogue in ICT to an Upper level for Reinforced  EU-EECA Cooperation' under Seventh Framework.

assistant: **Concept**

Following the tradition of scientific collaboration between EU and the EECA region, and built on the sound outcomes and lessons learnt of three clustering projects (ISTOK-SOYUS, SCUBE and EXTEND), a group of leading EU and EECA specialists from twelve countries (Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russian federation, Tajikistan, Turkmenistan, Ukraine, and Uzbekistan) with complementary competences have come together in the PICTURE project with the sole purpose to bring the ICT R&D policy dialogue and cooperation between EU and EECA to an upper level. The overall aim of the project is to engage the EU and EECA stakeholders from across  research, academia, industries, government and civil society to enrich and support the EU-EECA ICT Policy Dialogue, and to reinforce strategic partnerships between EU and EECA ICT organizations.To reach the objective of the project, the consortium will:-Update the EU-EECA ICT priorities for cooperation  and provide an overview of  the EECA ICT policy dialogue, currently existing in the region-Enrich the Policy Dialogue process and meetings between the EU and EECA,  encompassing findings from policy research and stakeholder views dealing with common R&D perspectives, priorities, opportunities and challenges-Set up  and animation of working groups, focusing on Computing Systems, Internet of Services and ICT Policy-Organisation of  3 workshops on Computing Systems, Internet of services and ICT Policy topics,  with ten working groups meetings, providing input and follow up,-Implement pilot projects that would be different in each country-Recommend future co-operation initiatives-Explore and recommend existing EECA programmes in order to open new perspectives for participation of the EU ICT teamsAs final outc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Monitoring of Animals for Feed-related Risks in the Long Term' (MARLON) under Seventh Framework.

assistant: **Objectives**

While there are many European scientific activities for each of the items related to either animal health or the occurrence of GM ingredients in animal feed, the proposed MARLON project will be unique in bringing these widely different fields of scientific expertise together for the cross-disciplinary task of developing an epidemiological model for the case-specific monitoring of potential health impacts of GM animal feeds in livestock.More specifically, the proposed MARLON project will create an inventory of which epidemiological and monitoring initiatives exist, both within and outside the EU, which could provide useful data for the purpose of monitoring for health impacts of animal feeds, in particular those containing GM ingredients, on livestock animals.  It will also collate, in a systematized manner, information on the factors that have to be considered when developing an epidemiological model specifically geared towards this purpose.  These factors include 1) the possibility to determine the exposure of animals to GM feed ingredients, 2) the health indicators that have to be considered for particular cases of health impacts identified during pre-market risk assessment of the GMOs, 3) the characteristics of the animal feed and livestock production chains.  The project also will develop an epidemiological model specifically geared towards establishing links between measured health effects in livestock and their intake of GM ingredients from animal feed.As previously stated, there are many activities in the EU focusing on the specific items that together constitute the cross-disciplinary research within the proposed MARLON project, but so far none of them has done this in its totality for the specific purpose of linking health impacts in livestock to GM feed consum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cyp-450 biosynthesis of Lyngbya majuscula natural products' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The filamentous marine cyanobacterium, Lyngbya majuscula (order Oscillatoriales) is a prolific source of modular natural products, some of which have shown promise for the treatment of cancer, diabetes, HIV and Alzheimers disease. However, the failure to grow its axenic cultures (because of the lack of the nifH gene) suggests that obtaining the natural products from the cyanobacterium in sustainable yields is enigmatic. My investigations into the Kenyan L. majuscula molecular diversity established it to be encapsulated by a sheath of brightly coloured epibiotic bacteria (EB) species, representative of a group of phyla that are an especially important source of novel natural products in drug discovery. Consistent with the paucity of natural product genes (a mere 3%) observed in the L. majuscula 3L draft genome sequence, there are serious concerns on whether the nearly 300 compounds isolated pan-tropically from L. majuscula originate from the cyanobacterium or EB cohabiting with it or both. This study therefore aims to investigate the heterologous cytochrome P450 (cyp450) mediated biosynthesis of L. majuscula natural products from EB cohabiting with it. The Kenyan L. majuscula is the source of the modular homodolastatin 16 (HMDS 16) and antanapeptin A (ANTAP A). Specifically, EB will be screened for polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) megasynthase gene clusters targeting HMDS 16 and ANTAP A. Gene clusters encoding for HMDS 16, ANTAP A and cyp450 flanking the clusters will be amplified from cDNA using specific primers for the gene models. PCR amplification products will be cloned and resulting plasmids transformed into a Saccharomyces cerevisiae shuttle vector for co-expression with cyp450. Methanolic extracts of the recombinant cultures will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Factors associated with the severity of measles and of delayed complications of measles' (1994-1998).

assistant: **Innovation**

* To compare levels of IL-5, IL-10, and IFN-gamma, at recruitment, 6 weeks and 6 months post-recruitment, in children with and without complications within 6 weeks of rash onset, among those who had no complications at enrollment. * To determine if there is an association between levels of IL-5, IL-10, and IFN-gamma at 6 weeks and 6 months post-measles, delayed-type-hypersensitivity (DTH) responses at 6 weeks and the development of complications (pneumonia, severe pneumonia, invasive diarrhoea, or hospitalisation for other reasons) 6-24 weeks after measles onset.* To compare the risk of complications among vaccinated vs unvaccinated cases.* To determine the association between cytokine profiles at 6 weeks and 6 months post-measles onset and early age at measles infection, sex, and vaccination status.* To compare cytokine profiles measured by whole blood assays with results of conventional assays on PBMCs on a subsample of children.Expected Outcome* Information on factors associated with early and delayed complications from measles.* Confirmation or not of the hypothesis that complicated measles cases have a bias towards a Th2 response* Establishment of the capacity to conduct whole blood assays for cytokines at ICDDR,B* A paper for publication in peer-reviewed journals.This a nested case-control study within a study evaluating long-term morbidity after measles. Commercial ELISA kits will be used to measure IL-5, IL-10, and IFN-( levels in supernatant from whole blood assays at recruitment, 6 weeks and 6 months at ICDDR,B on approximately 200 measles cases. Cases and controls will be defined among measles cases with and without complications at different times after measles onset. The following factors will be investigated for a potential association with early and late