RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Functions of non-coding RNAs in protein synthesis and homeostasis during aging' in the context of a Horizon 2020 call.

assistant: **Objectives**

Because old age is the largest risk factor for many human diseases, it is one of the key challenges of our time to find ways to increase healthy lifespan and reduce the loss of health in later life. Inhibition of protein synthesis is capable of extending the lifespan of a number of organisms and has been shown to ameliorate symptoms in models of several age related diseases. Recent studies have shown that non-coding (nc) RNAs frequently interact with translating ribosomes, although little is known about their function there. In previous work, I discovered a ribosome-bound ncRNA to be required for both the inhibition of translation and the increase in lifespan seen in insulin signaling (IIS) mutant worms. However, due to a nematode-specific RNA trans-splicing mechanism, affecting post-transcriptional gene regulation, the relevance of these results to others organisms remains unclear.Given the crucial role protein synthesis plays in lifespan determination and the unexplored functions of ncRNAs in this process, I propose to systematically investigate the role of ncRNAs in translation and longevity. My goal is to identify ncRNAs that interact with ribosomes that have an effect on proteostasis or post-transcriptional gene regulation and consequently on lifespan extension and understanding their function.


**Keywords:** Aging ,  non coding RNA ,  ribosome and translation ,  post-transcriptional gene regulation ,  insulin, insulin growth factor signaling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sugar-linked Ruthenium-anticancer Complexes' (SURUCO), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is a major cause of death in Europe, being second to heart disease and responsible more than 1.7 million (6.7 worldwide) lives every year. It is expected that these numbers will rise dramatically such that by 2020 more than 16 million new cases will be registered, with the number of deaths more than 10.3 million people per year worldwide (in Europe the number of deaths is estimated to rise to at least 2 million per year). In recent years improved early diagnosis and treatment options have contributed significantly to the battle against cancer. Nevertheless, there are still many major tumors that cannot be treated and one of the major approaches to overcome this problem is to develop new active anticancer drugs. In this project, a promising approach to new polynuclear Ru-arene metal complexes based on the sugar phosphite moiety is described. The approach combines the highly effective polynuclear concept, established for Pt-anticancer complexes, with a new mode of action and transport provided by ruthenium-arene compounds. The polynuclear Ru-system should endow the compounds with improved cytotoxicity and the sugar component should provide high tumor-affinity (selective uptake into the tumor via the transferrin pathway and via upregulation of the glucalitic activity). In order to obtain a structure-activity relationship, a manifold of chemical characterization including structure elucidation, (bio)analytical studies on the binding to biological targets and in vitro assays are planned.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrated Niche Theory: linking environmental, compositional and functional change on coral reefs' (2021-2027).

assistant: **Concept**

Idea: CoralINT aims to deliver the ability to predict spatio-temporal change in biodiversity and the consequences of this change for ecosystem function. To achieve this aim, I will develop an Integrated Niche Theory linking three niche concepts: Grinnell’s niche (what a species needs), Elton’s niche (what a species does) and niche construction (how the species function changes the environment). The key to this integration lies in how species are sorted along each of the niche axes (environmental gradients, functional rates and niche construction rates). I will map the dynamic implications of different types of bivariate sorting to the development of positive and negative feedback loops. This new theory will allow predicting the indirect consequences of selection on one axis to change along the other two axes. I will test INT with environmental, compositional, and functional data extracted from 3D maps of coral reefs and its coral inhabitants.  Ground breaking features: CoralINT sits at the interface between theory development and cutting-edge empirical data. I anticipate coralINT will produce 3D maps for a total area of >26,600 m2 with mm scale resolution, distributed among 100 sites along a 2,000 km latitudinal gradient. Within these maps we will follow >100,000 coral colonies through time, measuring and inferring structural and demographic rates across >200 species and environmental variation in space and time. Working at organismal and ecosystem scales will enable coralINT to develop mechanistic understanding of the processes connecting environmental, compositional and functional change. Objectives: develop a new Integrated Niche Theory; quantify the effects of the environment on corals’ distribution and functional rates; determine if function can be predicted from c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CARBON-NEUTRAL PRODUCTION AND DIRECT FUEL-CELL DEPLOYMENT OF ISOPROPANOL AS ENERGY CARRIER' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The use of condensed, synthetic energy carriers offers a prominent solution to decarbonizing heavy-duty transport, such as waterborne mobility. Fuel cells offer superior efficiency and emissions reduction over internal combustion engines for onboard energy retrieval. Hydrogen is considered the major contender energy carrier for fuel cell propulsion, but high compression costs and costly infrastructure for safe storage and bunkering in compressed or liquefied forms hinder widespread adoption. Methanol emerged as an alternative, enabling onboard hydrogen generation via reformers integrated with hydrogen fuel cells. However, its use releases significant amounts of CO2. IsoPROPEL aims to revolutionize this paradigm by pioneering the synthesis of isopropyl alcohol (IPA) as a renewable e-fuel of non-biological origin. Leveraging recent breakthroughs by the partners in electrified chemical-looping and tandem catalysis, an innovative process to selectively produce IPA from CO2 and renewable hydrogen will be validated at TRL4. Additionally, IsoPROPEL will advance the direct isopropanol fuel cell (DIFC) to TRL4 after developing fuel cell components with enhanced tolerance to this cell’s unconventional working medium. This emerging fuel cell technology enables direct energy recovery from liquid IPA via selective electro-dehydrogenation to acetone (ACE), eliminating CO2 emissions onboard and the need for alcohol reformers. It also enables seamless cycling between ACE (discharged) and IPA (charged) energy carrier forms via mild hydrogenation “recharging,” without pressurized or liquefied hydrogen throughout fuel synthesis, use, and recycling. Inland waterway transport serves as a test case. IsoPROPEL will optimize e-fuel production, DIFC integration with ship powertrains, and double
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Analysis of tridimensional changes caused by type 2 Diabetes-Associated varianTs' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Despite the worldwide growing incidence of type-two diabetes (T2D), the molecular mechanisms are largely unknown. Genome Wide Association Studies (GWAS) have identified dozens of loci harbouring common SNPs that affect T2D susceptibility. The host lab recently showed that many associated SNPs lie in clusters of islet-specific regulatory elements that form tridimensional chromatin structures in the nucleus. This project aims to evaluate how common genetic variation could impact the tridimensional chromatin structure and transcriptional activity at the level of broad regulatory domains, and ultimately assess its influence on T2D risk. To this end, allele-specific chromosome conformation capture maps will be developed and analysed together with existing reference regulatory datasets of expression profiles, histone modification marks and transcription factor occupancy in human islets. To further define the function of allele-specific interactions, genetic modification experiments will be carried out on selected disease-relevant regulatory elements.  These studies can shed novel insights on how common sequence variation contributes to T2D susceptibility and can lead to the identification of novel non-coding functional variants.


**Keywords:** Type-two-diabetes, GWAS, SNPs, long-range interactions, tridimensional structure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'euroFOT (European Field Operational Test on Active Safety Functions in vehicles)'.

assistant: **Innovation**

The Intelligent Car Initiative has identified road safety, energy efficiency, and traffic congestion as the main challenges currently being faced by European transportation. Despite their severity, these issues may be improved with the use of new in-vehicle technologies currently not available in the market. However, implementing new technologies implies a risk to manufacturers. Factors such as different markets, user acceptance, and real-world driving conditions are difficult to assess before in-the-field testing. This restricts our capabilities for making the correct business and political decisions for deployment, and for understanding which aspects would benefit from further development the most.<br/>The goal of EuroFOT is to identify and coordinate an in-the-field testing of new Intelligent Vehicle Systems with the potential for improving the quality of European road traffic. This permits assessing their effectiveness on actual roads, while determining how they perform towards the intended objectives. In addition, this offers an early publicity of the technologies, and enables the analysis of the user acceptance and its subsequent potential for market penetration.<br/>This will be accomplished through a series of discrete steps. First, EuroFOT will specify a test plan identifying proper driving scenarios, factors with maximum safety potential, and expected results. Subsequent steps will involve the recruitment and training of customers, with the necessary installation of data loggers into their vehicles. In this way, customers will drive and collect data under normal driving conditions.<br/>During the final section, EuroFOT will analyse both objective and subjective data describing the driver behaviour and adaptation, vehicle dynamics, and system acceptance. This w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Things for Politics' Sake: Aesthetic Objects and Social Change' in the context of a Horizon Europe call.

assistant: **Objectives**

THINGSTIGATE aims to theorize how aesthetic objects mediate sociopolitical transformation. In a world where affective imagination increasingly sways society and politics, it is urgent to grasp the link between imagination, emotions, and sociopolitical institutions. Art for social change, ‘socially engaged art’, is pertinent, but its theories now dwell on usefulness. Imbued in a post-object relational art tradition despite the material turn in humanities and social sciences, these theories overlook aesthetic objects’ role in social processes. Tackling this, THINGSTIGATE draws on empirical hypotheses to assess aesthetic objects as a pivot of imagination, emotions, institutions. It extends aesthetic cosmopolitanism in confronting the imagined community of the nation-state as an institution. How do aesthetic objects behave in social relations, instigate change through imagination, intervene in the nation-states’ institutionalizing paths? How can they transform the imaginaries of a specific nation-state, and of a world beyond the nation-states? The study’s novel interdisciplinary methodology dissects the making of sociopolitical cultures by empirically tracing socially engaged objects – physical and digital – while they are in action, via artistic practice-based research. A posited framework will link imagination, institutions, and a relational objects typology distilled from major archives worldwide. It is then tested in two quantitative and qualitative fieldwork streams: iterative – via Make Your Own Passport workshop series in highly diverse public spaces in Sweden, Italy, and USA– and longitudinal –via 1965 Setiap Hari, a transnational social media initiative for Indonesia. The study’s impacts are manifold: in opening up a new, theoretically grounded methodological field
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The interactive side of emotion:  A neuroethological approach in freely-moving monkeys'.

assistant: **Concept**

A general principle of brain functioning is the exploitation of neural substrates for self-related processes, such as action planning, decision-making and space coding, to map those of others. Indirect evidence indicates that similar agent-based coding may characterize emotion as well. How does the primate brain represent emotional displays (EDs) of self and others from the single-neuron to the network level? EMACTIVE will leverage state-of-the-art wireless recording technologies developed during my previous ERC StG to crack the code of agent-based representation of EDs.I will first record single-neuron activity from the anterior cingulate cortex (ACC) (WP1) and amygdala (WP2) alongside physiological data of freely moving pairs of macaques, aiming to identify self- (ST) and other-type (OT) neurons encoding EDs: I hypothesize that an animal’s ST neurons drive its Eds, which in turn trigger OT neurons of the partner, facilitating behavioural coordination. By means of neural decoding approaches, chemogenetic inactivation and wireless intracortical microstimulation, I will assess the causal role of each region in the control of specific EDs during interactive situations. Next (WP3), neuronal tracers will be injected in the amygdalar and ACC territories hosting ST and OT neurons, providing the connectional fingerprint of agent-based representation of EDs. Finally, in WP4 we will record neuronal activity simultaneously from multiple regions anatomically connected with the ACC and amygdala (capitalizing on findings from WP3) in two additional pairs of freely interacting monkeys (multiareal hyperscanning), thereby revealing the neural and contextual factors affecting interbrain synchrony and its role in behavioural coordination.EMACTIVE will reveal the single-cell and network m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Endoscopic Comprehensive Optical Multimodal Molecular Intelligent Imaging'.

assistant: **Innovation**

Optical imaging has exceptional potential for medical diagnosis, because it can provide high spatial resolution and molecular contrast. However, for in vivo imaging in humans, the poor penetration of only a few millimetres is a major obstacle. Optical endoscopes solve this problem, but currently most of them only perform non-advanced, classical white light imaging. Also, the speed of current devices is not sufficient to comprehensively scan entire organs at microscopic resolution. Hence, medical imaging is still dominated by non-optical techniques like X-ray, ultrasound and magnetic resonance imaging.The objective of ENCOMOLE-2i is to push the performance of advanced optical in vivo imaging techniques to cross the application threshold for clinical research and practice. An endoscopic multi-modal molecular imaging platform will be developed with unprecedented capabilities for the diagnosis of disease.The hardware technology development includes three novel imaging modalities. Optical coherence tomography with line rates of several Megahertz will be used for comprehensive structural imaging over large areas. Time encoded stimulated Raman sensing, supported by a new type of two photon microscopy, will be used for guided and referenced molecular imaging. Combining these techniques into one system and interfacing it with a newly developed endoscope will generate great synergy. Moreover, the unique synchronization capabilities of these modalities enable a radically new strategy for more efficient data acquisition: The concept of adaptive “Intelligent Imaging”.The goal is to develop a universal endoscopy platform which can then be specifically tailored to the individual application. In the project the focus is on gastrointestinal imaging. The synergy between technological and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Demonstration of superradiance in a semiconductor nanostructure' (SUPERRAD).

assistant: **Concept**

Superradiance (SR) refers to spontaneous quantum phase transition, in which a self-organized build up of coherent radiation within an ensemble of quasi-degenerate emitters occurs. It was first noted by Dicke back in 1954  that, with increasing their density, the collection of N radiators starts to emit much faster and stronger comparing to spontaneous emission of individuals. More precisely, when packing up N identical emitters into the space comparable with a cube of the radiation wavelength, instead of observing isotropic and exponentially decaying emission, one produces a fierce, directional radiation burst, having a lagged peak intensity scaling like N2 and N-times reduced duration with respect to the spontaneous emission. Apart from the fundamental aspect, the research for SR is motivated by the prospects in producing ultra-short, intense, coherent light pulses - in alternative to lasers. The prerequisite for creating a SR emission is a spectral uniformity of participating transitions. For that reason SR was first successfully observed in atomic and molecular ensembles. As concerns semiconductor nanostructures, nowadays widely used in optoelectronics, the evidence for SR has never been provided, as the SR effect is obscured by the spectral inhomogeneous broadening in a semiconductor matrix.  The goal of this project is to achieve the first proof for SR within an ensemble of individual emitters embedded in a nanostructured semiconductor. To this aim, we will focus our efforts on donor-bound-excitons (D0X), which are excitons (Coulomb correlated electron-hole pairs) localized on donor impurities in a semiconductor, for instance Si replacing Ga atoms in a GaAs lattice. D0Xs are characterized by small, sub-meV, inhomogeneous broadening, large oscillator strength and a