RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Real-time analysis of video image structure'.

assistant: **Concept**

Image processing techniques are bringing a whole range of innovative applications to the world of digital video. An early commercial application released by one of the project partners in 1995 is the electronic billboard. This image processing system is able to detect and track a real billboard or another target in the live broadcast flow of a sports event, and to insert a synthetic 'electronic billboard' to replace it in the video signal. This can be used to optimise the impact of sponsoring to specific audiences. The goal of the EPSIS project is to enhance this system by launching a new research activity focused on obstacle processing.The anticipated project results will enable the insertion of a new billboard even when a player is partially masking the targeted 'real' billboard, with a minimum number of constraints.Similar techniques will also be exploited in a different application, known as the virtual set. This application allows images of actors and props recorded in an appropriate studio to be superimposed on a synthetic background. Most virtual set solutions available today require instrumented cameras to track their location and orientation and the well-known chroma-key technique to insert actors and props in a synthetic background. The techniques developed in this project will partially or completely suppress the constraints of chroma key.The results of the project will give the consortium a competitive edge on players from outside Europe, mainly from the US.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Directed evolution of ketoreductases in gel-shell beads' under Horizon 2020.

assistant: **Concept**

Optically pure secondary alcohols are required in the manufacture of many pharmaceutical products. Ketoreductases (KREDs) capable of reduction of ketones to the corresponding secondary alcohol have been improved through classical directed evolution campaigns but a limiting factor has always been the challenge of matching selection conditions to the final scaled-up reaction. Here we propose a solution to that problem.  The Host group previously described the formation of gel-shell beads, agarose beads surrounded by a size-selective shell (Nature Chemistry 2014, 6:791). The beads allow screening of individual members of an enzyme library using flow cytometry.  As small molecules can be readily exchanged, while enzymes are retained, the process not only affords precise control over selection conditions but also makes it ideal for continuous flow processes. To support this endeavour, sensitive assays for the high throughput detection of ketoreductase activity and enantioselectivity will be developed. Directed evolution will then be performed with selection for the efficient use of macromolecular derivatives of the NAD(P)H cofactor and improved tolerance to high substrate /solvent concentrations. Throughout the project, intensive contact will be maintained with Industrial Partner GlaxoSmithKline, leading up to flow bed reactor trials during a secondment. This project will provide the Beneficiary with an excellent training in biocatalysis, broadening his skill set and opening up new career opportunities in Europe’s growing Green Chemistry Sector. The Host laboratory is at the forefront of directed evolution of enzymes. Through the secondment at GSK, the Beneficiary will be able to transfer this technology to industry. Excellent training courses offered by the University of Ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Conservation of built heritage: Natural Formulations agaINst bio-dEterioration' (CoNFine) targeting Horizon Europe.

assistant: **Abstract**

Microorganisms can generate serious problems for the conservation of our shared cultural heritage: bio-colonisation by bacteria, algae, and moulds can induce physical, chemical, and aesthetic damages. Current chemical methods used to remove and prevent bio-colonisation of built stone heritage involves the use of toxic biocides, despite the risk to the environment and operators. Antimicrobial nanoparticles and naturally occurring enzymes have been alternatively proposed; however, they often show poor efficacy, along with low operational and environmental stability. CoNFine aims to develop innovative and high specificity natural-based bio-deterioration mitigation solutions tested on remains at the Oxpemul archaeological site, located in Mexico's Calakmul Biosphere Reserve. The project will produce and test new formulations based on enzyme immobilisation on metal-oxide nanoparticles and polymeric hydrogels. Presumably, enzyme anchoring on naturally occurring nanostructured surfaces will enhance the inherent enzymatic activity and stability, thereby increasing their overall efficacy. The highly trans-disciplinary project involves a multi-analytical approach to provide new solutions for mitigating bio-deterioration. The efficacy, compatibility, and longevity of the CoNFine products will be monitored during the MSCA-GF funded period and afterwards, using a Citizen Science initiative for long-term feedback. In this way, CoNFine will significantly contribute to the development of more respectful conservation solutions, which are also in line with the UN’s Sustainable Development Goals.CoNFine provides innovative beyond state-of-the-art materials to protect cultural heritage surfaces and preserve cultural identities. Importantly, it creates a truly unique training opportunity fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Outplaying the hardware lottery for embedded AI' to be submitted under Horizon Europe.

assistant: **Abstract**

The next wave of smart applications in our society will need embedded devices (robots, wearables, etc.) with increased intelligence at much reduced energy and latency cost. Compared to current embedded platforms, up to 1000x efficiency gains could be achieved through tight processor-algorithm co-optimization. However, due to the slow development cycle of processor chips (many months to years) in comparison to algorithms (hours to weeks), this co-optimization today merely boils down to selecting algorithms which run well on mature, available hardware. As these processors and their tooling have been optimized for mature algorithms, not the inherently best algorithm wins, but the one that happens to best fit the available old-school hardware platforms. This hardware lottery holds back innovation, severely impacts embedded AI execution efficiency, and narrows the market to a few large companies.The BINGO vision to break this innovation deadlock is to enable heterogeneous compute platform customization for a given AI workload in a matter of days (100x faster), through rapid selection and assembly of prefabricated co-processor chiplets. This needs breakthroughs in:  a.) A library of embedded-AI-optimized co-processor chiplets, surpassing the SotA in terms of dataflow heterogeneity for improved efficiency (100x over CPU); and inter-operability in heterogeneous chiplet meshes on a reusable breadboard interposer.  b.) Rapid cost models and workload schedulers for beyond-SotA heterogeneous platform customization: automatically deriving the optimal chiplet combination for an application, assemble it and deploy, all in a few days.Optimizing across the disciplines of chip design, computer architecture, scheduling, and AI fits perfectly to my expertise gained at KU Leuven, imec and I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A New GEnetic LABoratory for non-invasive prenatal diagnosis'.

assistant: **Innovation**

This project will develop a family of In-Vitro Diagnostic Systems that will transfer for the first time novel Non Invasive Prenatal Diagnostic (NIPD) methods in tube to a LabonaChip format. This family will consist of three research systems chosen to cover all prenatal diagnosis models:- ANGELAB1. This system will use a LabonaChip to extract fetal DNA from the mother´s plasma based on differences in methylated pattern between fetus and mother and captured by specific magnetophoresis, plus qPCR for monogenic diseases with a known mutation for: Spinal Muscular Atrophy, Cystic Fibrosis (CF), and X-linked disorders. It will be used only for high risk population.- ANGELAB2. It will use a LabonaChip to carry out immunoprecipitation (MeDIP) for fetal DNA extraction from mother´s blood and real time quantitative Polymerase Chain Reaction (real time qPCR) for Aneuploidies of chromosomes 13, 18, 21, X and Y. It will be used for population screening purposes.- ANGELAB3. This system will use the DNA sample provided from ANGELAB1 or ANGELAB2 and it will carry out Digital PCR on a LabonaChip to detect: CF (unknown multiple mutations), b-thalassemia and achondroplasia. I will be used for population screening purposes.All systems can manage 8 samples at a time. They can be modularly assembled to themselves, offering a system adaptable to different throughput needs.The consortium will also develop and integrate a LabonaChip Pilot Production Line (LPPL):- LPPL: This pilot line setup will provide a sustainable and economic LabonChip manufacturing. Materials, processes, and their life cycle will be considered. The environmental assessment will be carried out following ISO 14044. Quality control tools will be integrated along the entire production chain of LabonaChips.This project will end
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Glycans as Master Switches of B Cell Activity in Autoimmunity' (GlycanSwitch), addressing dissemination and exploitation.

assistant: **Impact**

Autoimmune diseases including rheumatoid arthritis (RA) are often life-threatening disorders with increasing disability having a negative impact on patients’ quality of life. Mechanisms leading to the breach of tolerance in development of autoimmunity are still largely unknown. Protein glycosylation is an essential regulatory mechanism in the immune system. We recently demonstrated that N-glycosylation of the variable region (Fab) of autoantibodies is a hallmark of RA development and progression. We also demonstrated that autoantibodies acquire these Fab glycosylation signatures already many years before disease onset. We herein hypothesize that Fab glycosylation at the level of the B cell receptor is a key molecular switch promoting the selection, activation and proliferation of autoreactive B cells leading to the concomitant breach of immunotolerance. Within GlycanSwitch, we will map the Fab glycome of various types of RA autoantibodies and autoreactive B cells. We will study the factors and underlying cellular mechanisms that regulate Fab glycosylation of B cell receptors and autoantibodies. We will investigate the immunological effects of Fab glycosylation and the impact in B cells signalling and activation in the context of molecular and cellular interacting partners in the immune microenvironment. Finally, we will test in relevant mouse models how Fab glycosylation of autoantibodies and autoreactive B cells contributes to the breach of tolerance. We expect that the obtained insights into the role of glycans as key checkpoint for the selection of autoreactive B cells and the rise of autoimmunity will provide leads for targeted therapeutic interventions as well as rationales for the early detection of RA and autoimmune diseases in general. We foresee that the knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pooling of European data to hamonise transnational research in breast cancer' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The proposal is to obtain a large Data Set of Breast cancers, from Breast Units representative of the presentation of the disease in Europe. No such large tunmour set, with carefully compiled and checked long-term clinical follow-up and with standardised histological and other measurements of tumour factors, exists in Europe. The Data Set will provide a critical mass, invaluable in translational research for relating tumour factors to clinical outcomes. The Consortium for the project provides a European Network of Excellence in Breast Cancer. At the conclusion of the project this will be expanded by other Units. In turn this will provide a huge Data Set with associated Quality Assurance of the data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sjörgen's syndrome - a strategy for clarifying the disease process that underlines a chronic disorder of the mucous membranes' (1994-1998) under Fourth Framework.

assistant: **Objectives**

- To characterize mechanisms of T cell-mediated immune response to exocrine glands in Sjögren's syndrome (SS). - To investigate the humoral immune response against endogenous antigens and viruses in SS patients. - To determine the role of apoptosis and its regulation in the etiopathogenesis of SS. - To identify associations between SS and immune response genes. - To develop rational bases for non-toxic immunotherapies of SS. - To identify markers useful in the diagnosis and monitoring of disease activity and efficacy of immunotherapies in SS.Sjögren's syndrome (SS) affects 0.5-1% of the population worldwide (2-3% among >50 years) and is a common cause of chronic discomfort and suffering in females, especially among the aging population. The target organs are the exocrine glands especially in mucous membranes of the eye and the mouth but also in the respiratory, gastro-intestinal and genito-urinary tracts. Current therapy provides only marginal symptomatic relief. However, the chronic destructive process with its attendant mucous surface disability progresses relentlessly in most patients. Consequently, there is an urgent need to clarify the disease process underlying this chronic disorder of the mucous membranes. In this Concerted Action a co-ordinated set of studies is proposed to investigate etiologic factors and pathogenic mechanisms in human and experimental SS. The present project is designed to promote interaction of experimental and clinical research, through the cooperation of European rheumatologists, cellular and molecular immunologists, and immunopathologists involved in SS research. The proposed characterization of mucosal immune-regulation and pathogenesis in this chronic inflammatory/autoimmune/rheumatic disease will yield direct important clinical insight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sustainability Innovations in Global Production Networks – Addressing Socio-Ecological Challenges in the Global Economy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the 21st century,researchers, policy makers and practitioners are confronted with formidable environmental and societal mega problems. Sustainability innovations that address these issues are gaining stature in research and policy. The development of innovative and context-adapted solutions is a complex issue; how to develop sustainable solutions that adequately address local and global needs is the critical challenge of our times. The aim of the project is to investigate opportunities and barriers for more sustainable development processes in the global economy. This will be realized through a novel approach that integrates the Global Production Network (GPN) approach with concepts of innovation studies focusing on sustainability innovations. Conceptually, both of these research fields investigate how global environmental and socio-economic challenges can be addressed. However, their mutual engagement is hindered by different research paradigms, terminologies and concepts. By themselves the two research strands remain limited in explaining how sustainable solutions can be created, implemented and diffused in the global economy. My proposed project is located at the interface of these approaches. The overall research question asks how sustainability innovations can be developed and implemented within GPNs in order to address complex socio-ecological challenges, and facilitate better working conditions in the global economy.The objectives of this interdisciplinary project are: 1To develop an integrated conceptual framework of sustainability innovations in GPNs. 2. To gain empirical insights on sustainability innovations in GPNs from a Global South perspective. 3. To derive and disseminate recommendations for policy makers and practitioners on how to address complex so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Formation of nano-scale clusters from atmospheric vapors' to be submitted under Horizon 2020.

assistant: **Abstract**

This research concentrates on advancing the understanding of the border between the gas and condensed phase by studying the formation of nanoscale clusters from atmospheric vapours (NanoCAVa). Cluster formation and growth is a crucial step in forming new aerosol particles in the atmosphere. We aim to resolve the role of molecular clusters in aerosol formation by targeted field measurements at various locations and precisely controlled chamber experiments. Using and further developing the latest measurement technology, and combining physical and chemical information, enables us to get a full characterization of neutral clusters, which is so far lacking. We utilize the results to create a better description of the dynamics of 1 – 5 nm nano-particles, which often cannot be treated with traditional theories, and to implement the concept of a cluster mode into the general view on the atmospheric aerosol size distribution. Understanding the factors controlling the growth of newly formed clusters into climatically relevant particles and cloud condensation nuclei (CCN) enables estimating their importance in the climate system more accurately. This project will facilitate the ER to pursue a successful research career in atmospheric science and establish her position as an expert of nano-particle measurement technology. It will also strengthen the role of the beneficiary and the partner organization as the leading groups in atmospheric nucleation research and their mutual collaboration.


**Keywords:** aerosol formation, molecular clusters
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Precision Chemical Nanoengineering: Integrating Top-Down and Bottom-Up Methodologies for the Fabrication of 3-D Adaptive Nanostructured Architectures' (NANO3D), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective of the research proposed in this document is to integrate top-down lithographic techniques which enable precise spatial patterning of surfaces from micron- to the nanoscale, with the controlled stepwise self-assembly and self-organi sation of nanometer scale chemical and biochemical entities to these surfaces, to fabricate three dimensional (3D) adaptive nanostructured architectures, which have demonstratable uses, in a fashion that will allow the processes to be scaled into proto-t ype production methodologies. The Nano3D consortia wish to be the first to demonstrate that nanostructures on surfaces can be created via an integration of top-down and bottom-up methodologies, by the self-organisation of self-assembled molecular bui lding blocks on nanopatterned surfaces, such that the nanostructures are able to adapt to the environment. Furthermore, the Nano3D consortia wish to further innovate in illustrating that this approach can be scaled up into a proto-type production proces s, such that automation and scaleability can be demonstrated. The Nano3D consortia will be innovating a new paradigm for manufacturing nanostructures on surfaces. The Nano3D proposal addresses Community socio-economic objectives from many view points . In response to the need for the transformation of industry towards higher-added value activities, one of the central objectives of the consortium is to develop new knowledge targeted towards high value-added technologies, including biotechnology, biom edicine and ICT. Successful innovations will ultimately enable new product and market development that will stimulate employment opportunities. Perhaps more relevantly, if Europe does not take its rightful place at the centre stage of emerging nanotechno logy research and develop