RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Travelling Sounds: A cultural analysis of sonic artefacts in postcolonial Europe' (2014-2020).

assistant: **Concept**

In this postcolonial and globalised world, the movement and criss-crossing of people, ideas, and sonic artefacts across the boundaries of nation states have become integral to the everyday cultural practices of individuals and groups. The vibrant connection between everyday cultural practices, artistic expressions, and new ways of thinking about culture in times of growing migratory movements and globalisation, has fascinated me ever since I started my PhD project on South Asian British musical cultures in the context of postcolonial history and theory. Aiming at establishing myself as an independent scholar, and at taking my expertise in cultural studies, sound studies and postcolonial studies to the next level, I am keen to study the postcolonial condition (Gilroy) of Europe not only through its musical, but also through its wider sonic cultures, taking into account sonic artefacts from different contexts, such as: sonic reinventions of urban space, the social functions of mobile devices, and the identificatory power of sound in cultural memory and commemoration. The overall aim of this project is to establish a comparative perspective which includes case studies from Denmark and the UK, and to investigate the cultural, social and political potential of sonic artefacts – music, voices, and everyday sounds – to forge a better understanding of Europe’s transcultural and entangled postcolonial histories and how they have shaped contemporary sound cultures. To exemplify this, the project focuses on specific iconic events and artefacts such as the sonic-cultural politics of “Greenlandic Square” in Copenhagen, the postcolonial signature sound of the steel drum at Notting Hill Carnival in London, and the 2011 so-called ""Blackberry riots"" addressing its use of social media
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Synthetic Lethal Phenotype Identification through Cancer Evolution Analysis'.

assistant: **Objectives**

Prostate cancer (PCA) is a genetically heterogeneous disease. Advances in targeted hormonal therapy (second generation anti-androgens) have led to more effective management of castration-resistant prostate cancer (CRPC). Despite these highly potent drugs, disease recurs with new genomic and epigenetic alterations. In this ERC proposal, I will leverage my expertise in cancer genomics and a new computational methodology to unravel the landscape of lethal PCA, with a focus on determining the Achilles’ heel of these aggressive tumours.  In Aim 1, I will take advantage of DNA sequencing data from over 1000 patient-derived tumour samples and use highly innovative mathematical algorithms to create a detailed evolution chart for each tumour and identify driver events leading to CRPC. After nominating candidate drivers, we propose testing 10 using in vitro gain- and loss-of-function validations experiments (i.e., CRISPR/Cas9, shRNA, and Tet-On assays) in PCA cell lines using migration, invasion, and cell cycle as readouts. In Aim 2, I will focus on genomic events that occur in recalcitrant CRPC, positing that genetic alterations occurring prior or secondary to treatment harbour clues into resistance. In vitro validations will be performed on the top 10 biomarkers. In Aim 3, I will nominate synthetic lethality combinations by mining CRPC genomic data taken from Stand Up 2 Cancer CRPC clinical trials. I will prioritize mutually exclusive genomic alterations in genes for which approved drugs exist. The top 5-10 candidates will be validated in a prostate lineage-specific manner.  In summary, this ERC proposal will leverage my many years of expertise in PCA genomics and emerging public and private CRPC datasets to uncover driver mutations that will enhance our understanding of recalc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'GENEtic pathways for the Prediction of the effect of Irradiation-European normal an tumour tissue bank and data base' (2002-2006) under Sixth Framework.

assistant: **Objectives**

GENEPI 2 aims at the qualitative and quantitative further development of the European tissue bank and database GENEPI-ENTB, established with EURATOM support in FP5. It is dedicated to research in radiation effects and in the genetic determinants of the variation in individual radio-sensitivity. With tissues from more than 4.200 patients linked to solid outcome data stored, GENEPI is currently the largest infrastructure in this field worldwide.The final aim is to more than triple that number to enable the selection of statistically relevant groups for analysis and to keep all future avenues of research open. An inestimable plus value for the GENEPI tissues (DNA or lymphocytes and other normal and tumour tissues) obtained from radiotherapy patients is the database linked to it. For each tissue, treatment data (dose distributions with dose gradients, total dose, dose per fraction) and outcome data are recorded.It will be a major objective for GENEPI 2 to develop the tools to make these rich data easily searchable and available for distant querying. Another powerful new feature to be developed in GENEPI 2 aims at creating a logistical shortcut for the quest to identify the hypersensitive phenotype. Tissues will be collected from a group of patients who demonstrated an unexpectedly severe response to RT (+/- 1 out of 1000). This action will necessitate the collaboration of a large segment of the European RT community. Major attention will be paid to all aspects of quality assurance. A steering committee will oversee all protocols, use and access.Finally, a close collaboration will be established with the GENEPI-Low RT" consortium intent on using the GENEPI resource for its proposed "Low dose radiosensitivity" project submitted for this call as well as with other candidate us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Food web control of the global topsoil carbon cycling'.

assistant: **Innovation**

Soil food webs process 90% of the terrestrial primary production and regulate the second largest carbon pool on Earth – soil organic matter. Soil food webs themselves are regulated by soil animals through changes in microbial functioning, detritus quality, and physical soil structure. However, neither drivers of soil food web structure and functions nor their effects on global biogeochemistry and carbon stabilisation are quantified across large environmental gradients. CARBONWEB addresses this challenge at the global scale and tests the following Key Hypotheses: (A) biotic controls of soil food web structure and functions increase under conditions promoting biological activity and nutrient limitation; (B) consumption of detritus by consumers in soil food webs increases the stable fraction of soil carbon across ecosystem types; (C) the effect of soil animals on multiple ecosystem functions increases with temperature, precipitation, and nutrient limitation, proportionally to the total energy flux in soil food webs; (D) the global net effect of soil animals on topsoil carbon is positive (>10% increase) and will increase with climate warming. To test my hypotheses, I will use (1) the first comprehensive global monitoring of soil animal communities in the framework of Soil BON, (2) an EU-wide survey and isotopic experiments on carbon stabilisation, (3) steady-state and dynamic food web modelling and AI-based animal image analysis approaches, and (4) geospatial extrapolations. My experience in soil macroecology, functional ecology, large-scale project coordination, and the established collaborative network will help to ensure this project is successful. I will describe and mechanistically model the status and trends of energy fluxes, animal biodiversity, and carbon pools in g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Broad-spectrum Antiviral siRNAs: Influenza Strains Targeted by Anticipation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Fighting emerging viruses has been a major challenge in the development of novel therapeutics. With the current global changes and massive modification of the biosphere, the issue will surely increase in the future. To overcome this challenge, we will demonstrate on influenza that we are capable to produce active antiviral against a strain that is not yet existing. The BARISTA project will allow to develop a novel therapeutic approach allowing to preserve therapeutic activities over a wide range of influenza strains and we will demonstrate its efficacy on the influenza strain of the next outreach. This achievement will be obtained by guiding the design of chemically optimized siRNA by detailed NMR structural analysis. Those molecules will be tested both in vitro and ex vivo and their broad-spectrum activity will be demonstrated on past, present and future influenza strains. This project will therefore open the way to therapies that can be designed and optimized, even before the appearance of a novel strain, providing an invaluable help in fighting emerging viruses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Evolution and success of the multi-drug resistant M. tuberculosis SIT41 (LAM7-TUR) lineage' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mycobacterium tuberculosis (MTB) is the cause of tuberculosis (TB) in humans. Identification of the MTB lineage is of importance to tuberculosis control as it has shown that strain type may play a role in disease outcome, variation in vaccine efficacy and emergence of drug resistance. MTB strains of Beijing and Latin-American-Mediterranean (LAM) lineages were associated with hyper-transmissibility and drug resistance. In 2013 the European Center for Diseases Prevention and Control (ECDC) effectively lunched molecular surveillance of MDR TB at EU level. The typing of M. tuberculosis strains in Bulgaria confirmed strong association between MDR and SIT41 (LAM7-TUR) [SIT – Spoligo International Type] MTB lineage. Statistically 97% of the TB patients infected with drug sensitive SIT41 MTB strain develop MDR tuberculosis. SIT41 is marker genotype for MDR TB. Urgent measures are needed to control and limit the expansion of the SIT41 lineage. We aim to promote personalised treatment of tuberculosis based on the genotype lineage of the TB pathogen and reducing the TB multidrug-resistant burden. The project has two objectives. First: Application of the next-generation sequencing data for genotyping of M. tuberculosis strains based on SNP data for tracking the origins, evolution and success of the SIT41 (LAM7-TUR) lineage, and second: Development of rapid screening methodology to identify the SIT41 (LAM7-TUR) genotype including mutation analysis to first and second line tuberculostatics drug resistance. Objectives will be achieved by fostering radically new technologies, by exploring novel ideas for MTB genotyping and improvement of the classical TB treatment scheme.The project is timely because it has relevance to the Work Program Horizon 2020 focus area: Personalising health and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Attract, Retain and Develop New Nuclear Talents Beyond Academic Curricula', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The primary motivation of the ENEN+ project is to substantially contribute to the revival of the interest of young generations in the careers in nuclear sector. This is to be achieved by pursuing the following main objectives: • Attract new talents to careers in nuclear.• Develop the attracted talents beyond academic curricula.• Increase the retention of attracted talents in nuclear careers.• Involve the nuclear stakeholders within EU and beyond.• Sustain the revived interest for nuclear careers.The ENEN+ consortium will focus on the learners and careers in the following nuclear disciplines:• Nuclear reactor engineering and safety,• Waste management and geological disposal,• Radiation protection and• Medical applications.Integration of further nuclear disciplines (e.g., nuclear chemistry, decommissioning, fusion engineering…) and sustainability of the ENEN+ accomplishments beyond the project life of is foreseen within the existing ENEN Association and its members and partnering of ENEN association with ongoing and proposed projects.The attraction, retention and development of the new nuclear talent can only be sustained beyond the project life through strong partnership of all nuclear stakeholders. Involvement of various nuclear stakeholders including academia, industry, international organisations (ENS, FORATOM, IAEA, NUGENIA) and Technical support organisations in the ENEN+ consortium is therefore of primary importance for the success and sustainability of the proposed activities also beyond the life of ENEN+. A mobility fund of more than 1.000.000EUR for European students researchers and learners is established in the project.


**Keywords:** Attract talents through international mobility enhancement of learning access to infraestructures and attractive research expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-cloud Execution-ware for Large-scale Optimized Data-Intensive Computing' to be submitted under Horizon 2020.

assistant: **Abstract**

MELODIC will enable data-intensive applications to run within defined security, cost, and performance boundaries seamlessly on geographically distributed and federated cloud infrastructures. Serving the user’s needs and constraints, MELODIC will realise the potential of Cloud computing for big data and data-intensive applications by transparently taking advantage of distinct characteristics of available private and public clouds, dynamically optimise resource utilisation, consider data locality, conform to the user’s privacy needs and service requirements, and counter vendor lock-in.These benefits are achieved by integrating and extending the results and the open source platforms available from three major European Cloud projects with the Hadoop and Spark big data frameworks: The PaaSage platform will be used for intelligent and autonomic cross-cloud deployment and is extended with data aware modelling and deployment configuration reasoning; the CACTOS platform is extended with support for Hadoop and Spark in cross-Cloud application deployment and management; and the PaaSword platform will ensure unified data security and cross-Cloud privacy.MELODIC will integrate with the existing open source development teams for these platforms and the contributions will be released back to the used platforms as open source. The integrated MELODIC platform will be maintained and exploited by a professional software house, and tested in several demanding real world applications: scalable Customer Relationship Management, real-time optimised traffic routing, and fast and scalable processing of genomic data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Prokaryotic activity and phylogeny of oceanic systems' (PAPHOS), addressing dissemination and exploitation.

assistant: **Impact**

This proposal is built on phylogenetic information on the prokaryotic communities of the coastal North Sea and in the open North Atlantic water. The sequence information available on the prokaryotic community will be used to construct oligonucleotide probe s for the main prokaryotic species present at these 2 sites. Using these fluorescent oligonucleotide probes in combination with the recently developed method catalysed reporter deposition-fluorescence in situ hybridisation (CARD-FISH), we will be able to determine the dynamics of the main components of the prokaryotic community. This CARD-FISH method is sensitive enough to allow detection of prokaryotic cells even in the deep ocean and will be combined with microautoradiography (MICRO-CARD-FISH).This combination of methods, recently developed in the host institution, allows the detection and enumeration of specific prokaryotic species and, at the same time, information is obtained on the utilization of specific compounds. Thus, the proposal directly addresses the functional biodiversity of marine prokaryotic plankton communities. MICRO-CARD-FISH will be used to determine the fluctuations in the activity of the main drivers of the prokaryotic succession in near-shore waters. Specific attention will be paid on the relation and activity pattern between Bacteria and Archaea, the 2 domains of the prokaryotes. Pelagic Archaea are not cultivable and their substrate requirements are unknown although they make up the majority of prokaryotic cells in the deep ocean water column and become numerically important in the North Sea in winter, when the number of Bacteria is low.Using MICRO-CARD-FISH, it has been shown that planktonic Archaea are capable of taking up bicarbonate or CO2 derived from it. The intention of the proposal is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Intelligent and luminous textiles' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Driven by advances in R&D and in inorganic light-emitting diodes (LEDs), the Lighting industry is expected to change substantially in the next five years. At the same time, a shift in the value chain from components (LEDs) towards intelligent lighting systems is expected. This technology trend is mirrored by similar market trends substantiated by end-users expectations for miniaturization of electronic devices and integration of intelligence in light emitting devices. Consumers will wish to have a more pervasive presence of intelligence (e.g. to communicate, to display information, and to process data). In order to lead in R&D as well as in manufacturing and market applications, the European Lighting industry has to fully harness the potential of the inorganic LEDs-based illumination by investing in new technologies that will allow for new types of lighting solutions via cost-competitive highly reliable manufacturing processes. These future energy efficient lighting solutions will not only drive and be driven by requirements of low total ownership costs (e.g. in B2B sales), but will also take into account new consumers' needs such as a more pervasive intelligence, novel design possibilities and novel user interfaces.<br/>i-Tex targets the Research, Development & Production feasibility of large area  intelligent lighting systems based on smart coated textiles.<br/>Although numerous research projects have investigated smart textiles with LED integration, none of them has targeted the development of technology and system architecture for reliable large area illumination systems. The main reasons for this are 1) the high costs and complexity in manufacturing of such smart textiles, 2) demanding reliability requirements of general illumination requirements , and 3) the optic