RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A leaky evidence accumulation process (LEAP) for consciousness' (LEAP), addressing dissemination and exploitation.

assistant: **Impact**

How we consciously experience the world remains a mystery in science. To tackle this problem, scientific works on perceptual consciousness contrast brain activity when participants consciously perceive a stimulus versus when they are unaware of it. To report stimulus awareness, participants need to make decisions. However, the extent to which the well-studied mechanisms of decision-making apply to consciousness is unclear. One possible reason is that standard neuroimaging methods lack the sensitivity to observe whether the mechanisms of decision-making also operate in the absence of task relevance, as when participants become conscious of a stimulus irrespective of any task. In this project, I will test the hypothesis that a mechanism of decision-making –evidence accumulation– explains how perceptual consciousness unfolds over time. First, I will develop a computational model of a latent evidence accumulation process (LEAP) and test it on behavioral measures of phenomenal aspects of perceptual experience: its duration and intensity. Second, I will search for single neuron activity in humans that instantiates evidence accumulation and test whether it also determines these phenomenal aspects of perceptual experience. Third, I will stimulate the corresponding brain regions to disentangle their causal role in either solely triggering perceptual experience or shaping it. Last, I will use the LEAP model to explain hallucinatory-like experiences in patients with Parkinson's disease and test whether deep-brain stimulation affects only decision-making –as previously shown– or also perceptual experience. By combining computational modeling and cutting-edge electrophysiology, the LEAP project will provide unique mechanistic insights on how neuronal activity determines perceptual e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Strategic user group for European research on TCAD' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

This Specific Support Action refers to the current IST Strategic Objective Pushing the Limits of CMOS, Preparing for Post-CMOS". In order to achieve this goal and a good competitive situation of Europe in this area, well-directed and highly cooperative research activities are mandatory. The objective of SUGERT is to promote the optimization of European research activities in the field of Technology Computer Aided Design (TCAD), which is extremely important e.g. to reduce costs and time spent during the development of new semiconductor processes and devices.To this end, SUGERT will start from the consolidated industrial specifications for process and device simulation defined by the preceding IST User Group UPPER+, which will within SUGERT be updated according to the development of the industrial requirements and of the scientific state-of-the-art. In order to support and promote the implementation of research actions required to fulfil these specifications, SUGERT will transmit these specifications to relevant research groups in industry, at institutes and at universities. It will interact with these research groups to promote the efficient use of resources available from European, national or regional sources to carry out the research needed to match the industrial requirements.Furthermore, consolidated information on these industrial requirements and on the related expertise available in Europe will, together with suggestions for research activities, be given to relevant public authorities to support them in establishing their research programmes. SUGERT will organize the European contributions to the "International Technology Working Group" on "Modeling and Simulation" within the "International Technology Roadmap for Semiconductors", which has the objective of defini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regulation and Function of Endocrine-Specific Splicing Programs in Pancreas and their Role in Diabetes' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Pancreatic beta cells are highly specialized cells that play a key role in maintaining glucose homeostasis by secreting insulin. Dysfunction or loss of beta cells results in diabetes, a worldwide growing epidemic. Extensive research has started to uncover the signals and transcriptional networks that control specification, differentiation and maturity of the different pancreatic cell lineages, and in particular of beta cells. However, posttranscriptional regulation during pancreas development has remained mostly unexplored. Alternative splicing (AS) is the main posttranscriptional mechanism that generates transcriptomic and proteomic diversity, playing essential roles in cell specification and functional specialization. My previous data suggest that beta cells activate neuron-related splicing programs involved in the regulation of insulin secretion. Moreover, pro-inflammatory cytokines (mediators of beta cell failure in type 1 diabetes) affect the splicing of signaling and pro-apoptotic genes that determine beta cell survival. However, the presence of beta- or endocrine-specific splicing programs and their role in diabetes remains to be clarified. In this project, we will investigate the regulation and function of endocrine-specific alternative exons. I will combine comparative transcriptomics, biochemical and functional studies, iPCS reprogramming and zebrafish knock-outs to: (i) comprehensively identify endocrine-AS exons, and study their regulation during beta cell differentiation and pancreas development; (ii) probe the phenotypic impact of endocrine-AS programs on beta cell differentiation and function; and (iii) Investigate the role of ENDO-AS exons in remodeling transcriptional and signaling networks involved in diabetes. We foresee that this project will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Study of environmental Arctic Change - Developing Arctic Modelling and observing capability for long-term environment studies' (2002-2006) under Sixth Framework.

assistant: **Objectives**

We are proposing an SSA SEARCH for DAMOCLES" that is based on recent initiatives started in Europe and the USA in the field of Arctic marine ecosystems and Global change, with specific emphasis on Arctic Ocean long-term observatories. The SSA will capital ize on opportunities and significant benefits arising from coordination of large scale research programmes such as the European Integrated Project DAMOCLES (Developing Arctic Modelling and Observing Capabilities for Long-term Environmental studies) and the US research program SEARCH (Study of Environmental ARctic Change). "SEARCH for DAMOCLES", positioned in the domain of Arctic Science, will be particularly timely in the context of the International Polar Year and will significantly contribute to the coordinated implementation of the DAMOCLES and SEARCH work programmes in the field of Global Change and Ecosystems. Close synchronization of these programmes will enhance the acquisition of pan-arctic data sets, and their analysis, the dissemination and archiving of results, as well as heightening public awareness. International workshops and conferences including other partners such as Canada, Russia, and Asian countries (Japan, China, and South Korea), will enable translation of the results into planning of integrated, future activities that will be based on the SSA "SEARCH for DAMOCLES". The coordination and synchronization of Arctic programs such as DAMOCLES and SEARCH, through an SSA is a unique opportunity to ensure the necessary pan-arctic coverage of observations and data evaluation for understanding Arctic system variability, avoiding major gaps and unnecessary overlaps. This EU-US SSA will also contribute to promotion and facilitation of future RTD activities via prospective studies, exploratory measures and pil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A novel swimming pool water treatment for the detection and elimination of excess cyanuric acid' (POOLSAFE) targeting Seventh Framework.

assistant: **Abstract**

Microorganisms in swimming pool water can pose a serious health threat and pool disinfection is therefore compulsory by law in all developed countries. The most common disinfectant is chlorine, which is always found in its active form, hypochlorous acid (HOCl), in pool water. HOCl is rapidly decomposed by UV light, losing its bactericide effect, and a continuous supply is needed to maintain safe levels of microorganisms in pool water.Cyanuric acid (CYA) stabilises HOCl and is added to pool water to slow down the degradation of HOCl. CYA does not degrade however, and the CYA concentration therefore rises steadily over time. At high CYA levels, chlorine is overstablised, rendering it ineffective as a disinfectant. This increases the risk of recreational water illnesses (RWIs) and acceptable levels of CYA are therefore regulated by law. Currently the only viable solution to this problem is to replace some of the pool water with fresh water, which poses environmental concerns due to the large consumption of water this implies. The effects of high CYA levels also have a negative effect on the image of the swimming pool facility and can lead to a loss of business. There is therefore a strong need to find a way to break down CYA in pool water.POOLSAFE will provide an effective and efficient solution to the CYA problem through the development of a soft sensor to monitor the levels of CYA and other pool water quality parameters, as well as a simple, cost-effective method for degrading excess CYA, using photocatalysis. With its two-fold method of ensuring that CYA never reach a hazardous level, POOLSAFE will reduce the environmental impact of swimming pool maintenance by eliminating the need to periodically replace the pool water, provide improved safety to bathers by ensuring th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Surgify Safety Burrs for safer bone surgery' under Horizon Europe.

assistant: **Concept**

6 out of 15 top surgical procedures include bone cutting, which are performed using surgical power tools such as high-speed drills. These drills are widely used in neurosurgery, otology (ear), and spinal procedures, which include some of the most demanding surgical bone operations. However, 30% of bone drilling surgeries can lead to severe soft tissue injury. Missing a target by only millimetres or applying slightly too much force can lead to severe complications threatening patients’ life. The revolutionary Surgify Safety Burr enables surgeons to cut bone accurately and efficiently without compromising the safety of important soft structures. Thanks to the scalable technology, the safety feature can be customized for wide range of applications e.g. orthopaedics, pediatrics or even robotics-assisted surgery.During the EIC project Surgify Safety Burr product platform will be designed, developed and commercialized to allow safer surgeries for everyone.


**Keywords:** Robotics for healthcare,Surgical bone drilling,Soft tissue protection,Sensory product,Micromechanical engineering,High-speed drill,Orthopaedics,Surgical safety burr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Next-generation targeted immuno-oncology therapy' (NEXIM) under Horizon 2020.

assistant: **Objectives**

In spite of enormous medical progress, aggressive forms of cancer remain one of the leading causes of death across the globe. Metastasized prostate, lung, breast and colon cancer account for a combined mortality of approximately 0,8 M lives in Europe per year. Immunotherapies, activating patient’s own immune system to target and destroy tumor cells, have shown enormous promise in the treatment of metastatic forms of cancer, creating a huge market with a €100B potential in 2022. However, these drugs are only effective in 15-25% of patients, and their use is associated with severe side effects. Therefore, there is an unmet medical need for next-generation of cancer immunotherapies with improved safety and consistent efficacy in a broader patient population.TargImmune, is a Switzerland based company with a mission to develop novel targeted immuno-oncology drugs that will improve the treatment of patients with aggressive tumors. Using our proprietary treatment technology based on the targeted intracellular delivery of an  RNA-analogue inside the tumor, we will provide novel systemic immune therapy for metastasized cancer with less side effects and improved effectiveness across all patient populations. Currently we have 3 drugs in development for prostate, breast cancer and solid tumors. All potential pipeline candidates address a highly attractive immune-oncology market, with the total addressable market for our first asset of €1.7B. The product is predicted to generate €466M of cumulative annual revenues through 10 % royalties over sales in the first 5 years,  as a part of licensing deal with a large pharmaceutical company.After initial investment round, we currently seek for additional funding to further develop our pipeline candidates. In the NEXIM project, we will final
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New generation wear and corrosion coating enabling European industry growth', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The objective of ThermaSiC is to commercialise and bring to market our disruptive coating based on Silicon Carbide (SiC).ThermaSiC is the first in the world to enable SiC coating formation by thermal spraying - a major advancement on thecurrent SoA-technology providing unique chemical-physical properties and superior coating performance in corrosive andharsh environments at high temperatures (up to 1,500°C in air). ThermaSiC will significantly increase the functional lifetime,lower weight, reduce maintenance and increase the performance of a wide range of engineering products – creating asignificant market pull by end-users.SC is a spinout company from NTNU where our prototype coating technology was developed. Our Phase I-type FeasibilityStudy is based on a successful commercialisation process by NTNU validating both the technical capability (IP/manufacturing) and market confirmation (done by Qittitut Consulting LLC). We have a highly specialised team of7employees with world-leading skills within material science and engineering, business and production ramp-upcombinedwith a professional Board of Directors for business strategy and a strong investor network.We have created 5 sequential and quantifiable Commercialisation Objectives focusing on overcoming the remaining barriershampering successful commercialisation:1. Technology maturation, elevating our current prototype technology from TRL6 to TRL8 (WP1)2. End user piloting advancing ThermaSiC from TRL8 to TRL9 (WP2)3. Supply chain development, up- and downstream (WP3)4. Product exploitation strategy development, market research and post-project funding (WP4)5. Innovation management and BIP development, IP management and stakeholder engagement (WP5)Through ThermaSiC we will significantly boost our growth - quantified as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Imaging Ageing Endothelium at the nanoscale - Doctorates' (ImAge-D) targeting Horizon Europe.

assistant: **Abstract**

ImAge-D will train a new generation of Doctoral Candidates (DCs) in the development and application of newly developed high speed and high-resolution imaging tools in biomedical research. The ten DCs will be cross-pollinated with concepts and skills in physics and biomedicine, in particular in super-resolution imaging, analytical image reconstruction, and optical micro-manipulation methods. These skills will be applied to reveal for the first time the functionality and morphology (below the diffraction limit of light) of living endothelial cells (EC) that present the main barrier between the blood/lymph and all organs and tissues, and how these vital cells change with ageing. Very little is known at the nanoscale about extremely important physiological functions of EC and their role in the transfer and/or clearance of metabolites and pharmaceuticals to vital organs, and how EC change with ageing. The current generation of optical nanoscopes, however, is rather slow and can only be applied to isolated, typically fixed (i.e. dead) cells rather than biomedically relevant tissues. Also, newcomers to the field need to familiarize themselves with a whole new set of potential problems that might arise in the use of optical nanoscopy, such as image reconstruction- related artifacts to name just one example.This is an area of research where European enterprises are very active. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instill an innovative, creative and entrepreneurial mind-set in ImAge-D's DCs, maximising economic benefits based on scientific discoveries. These specialised, highly trained, and mobile DCs will have greatly enhanced career prospects. The training in novel physical methods wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mental illness, substance use, and cardiovascular disease: Unravelling causal relationships' (UNRAVEL-CAUSALITY).

assistant: **Innovation**

Serious mental illness  depression, bipolar, and psychotic disorder  is among the leading causes of disability worldwide, disproportionately affecting people of non-European ancestry. On top of the burden posed by its symptoms, mental illness is also associated with comorbid health problems. The two most important comorbidities of mental illness, given their driving role in decreasing quality and duration of life, are substance (mis)use and cardiovascular disease. Whether these comorbidities arise due to causal relationships is surprisingly unclear. The causal direction is also uncertain: does mental illness lead to comorbidities, and / or do comorbidities increase the risk of (more severe) mental illness? Through several prestigious fellowships, I have established myself as an expert in epidemiological and genetic causal inference methods. In this ambitious project, I will bring together innovative approaches to unravel the relationships of mental illness with substance (mis)use and cardiovascular disease. My aims are to: 1) assess bidirectional relationships between mental illness and its comorbidities by conducting longitudinal analyses in (multi-ancestry) prospective cohort studies, 2) distinguish bidirectional relationships from shared genetic liability by jointly modelling the complete genetic architecture of mental illness and its comorbidities (genomic structural equation modelling), 3) establish causality by using only highly significant genetic variants as instruments for one variable and testing causal effects on another (Mendelian randomization), 4) fully unravel the nature of relationships between mental illness and its comorbidities by triangulating evidence from aims 1 to 3, and 5) assess how informing medical doctors about the outcomes of aim 4 influence