RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovation Associate for highly specific Tumour Associated Carbohydrate Antigens' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

CellmAbs is a recent but fast growing biopharmaceutical spinoff dedicated to the development of immuno-oncology agents that target only cancer cells, promoting the activation of the immune system and inhibiting growth of cancer in both early and late stages.In spite of many advances in diagnostic and treatment development, many cancers still have no targeted therapy or have limited or toxic treatment options. Early detection is crucial to optimize treatment and substantially reduce incidence and mortality. In spite of the advent of new and improved genomic and proteomic technologies, it has not been possible to identify cancer-specific therapeutic targets or molecules that are able to reliably and accurately predict outcomes during cancer management and treatment. Cancers such as colorectal cancer (CRC) have very poor standard of care and thus own an unmet need for reliable and specific targets. The discovery of tumour associate carbohydrate antigens (TACA) is very promising but is still very insipient due to lack of experts, knowledge and technology on the field.InnoTACA will address several unmet needs by presenting the grounds for hiring an Innovation Associate with relevant expertise and experience on groundbreaking technology to innovate TACA discovery to apply in cancer theranostic, combining high-quality transferable-skill training with excellent scientific training in glycomics. InnoTACA addresses the CellmAbs need of identifying highly specific TACAs, which would serve as a lead for the development of safer and more cost-effective immunotherapies, even for advanced unresectable CRC. The InnoTACA Associate and such immunotherapies will provide CellmAbs with improved products to capitalize and compete with current healthcare business and it will allow CellmAbs to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Core Components Supporting a FAIR EOSC'.

assistant: **Objectives**

FAIRCORE4EOSC focuses on the development and realisation of EOSC-Core components supporting a FAIR EOSC, addressing gaps identified in the SRIA. Leveraging existing technologies and services, the project will develop nine new EOSC-Core components aimed to improve the discoverability and interoperability of an increased amount of research outputs. FAIRCORE4EOSC will also contribute to the EOSC Interoperability Framework by establishing new guidelines on the new EOSC-Core components. The new components will be crucial to support the FAIR research life cycle. Five user-centric case studies (climate change, social sciences and humanities, mathematics, national research information systems, research data management communities) will drive the development and testing of the new components ensuring they are tailored to the user needs (co-design). All the selected case studies share similar challenges that are common to many other stakeholder groups: research communities at European and national level have datasets that currently cannot be found in the EOSC; they use Digital Object Identifiers (DOIs) but they are lacking PIDs for different levels of aggregation; they use community specific services to manage metadata that make cross-discipline reuse and interoperability complex. The user stories and best practices drawn by the case studies will be used to foster uptake of the new components beyond the project partners. The 22 complementary partners of the FAIRCORE4EOSC consortium have long-lasting experience in the provision and development of research data services, persistent identifiers, metadata and semantic registries, services and tools to archive and reference research software. The partners have also significantly contributed to the EOSC SRIA and are active members of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Neanderthal coastal adaptations in southern Europe and eastern Asia', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

NEARCOAST will advance our understanding of Neanderthal behavioural and foraging ecology, and the role of coastal environments to Neanderthal adaptive capacity and resilience through the Middle Palaeolithic. The project will apply a suite of bioarchaeological and molecular techniques on faunal remains recovered from key Neanderthal coastal sites (Figueira Brava, Complejo del Humo, Los Aviones and Üçağızlı II) located between the eastern Mediterranean and the Atlantic Europe. NEARCOAST will test the hypotheses that i) investment in shellfish procurement responded to a longitudinal gradient in intertidal profitability; ii) intertidal resources were mostly secured in colder months of the year, in response to the seasonally controlled altitudinal mobility of large ungulates, as proposed for Upper Palaeolithic and Mesolihic groups in these region. The fellow (Asier García-Escárzaga) is an archaeologist who integrates malacology, trace elements and shell stable isotopic analysis to study Mesolithic coastal adaptation. With NEARCOAST he will expand his research portfolio to the Middle Palaeolithic and receive training in vertebrate zooarchaeology, palaeoproteomic and on recent developments in trace elements. The project will elevate our scientific and public knowledge on Neanderthal coastal adaptation. It will expand the fellow’s transferable and specific skills in bioarchaeology, while placing him in a unique position for a career independence. NEARCOAST will make an impact in the field of Middle Palaeolithic Archaeology, and so doing will enhance the visibility of the fellow and institutions involved. The fellow will be supervised by Colonese (PI of the ERC-CoG project TRADITION), and will be part of the new generation of biomolecular archaeologists trained at the Department
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanics of Bi-Metallic Discs' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Bi-metallic discs are of considerable interest for land and aeronautical turbine manufacturers. Their use shouid allow large power (+50%) and efficiency (+10%) gains through: - higher service temperature (50 to 150 K), - simpler architecture, allowing for example an increase of the disk diameter by a factor of two, while keeping stresses as in present designs and lowering operating cost. In a bi-metallic disc, a high creep resistance alloy (with coarse grains eg. CG or single crystals eg. SC) is used for the rim, and a high medium temperatures strength alloy (with fine grains eg. FG) is used for the hub. Today, the main limitation for the introduction of this new technology is the complete lack of suitable testing and design methods and standards for these joints. As a consequence, such components cannot be designed and tested, and thus, not be used. The objective of the Bl-METAL project is to develop the basic scientific knowledge and corresponding methods for mechanical modelling and testing the behaviour and the fracture of bi-metallic joints. Major european land and aeronautical turbine manufacturers, EGT and TURBOMECA will participate as end users in this project. The TECPHY metallurgical firm will participate as manufacturer. The Institute for Advanced Materials of JRC-Petten will participate as testing, modelling (for single crystals to fine grains joints) and standardization research center. The Federal Institute for Material Research and Testing (BAM) from Berlin will study the single crystal behaviour. The Center for Research and Studies on Materials of CEA will contribute as a specialist in fracture mechanics and material testing and modelling, and will focuse on coarse grains to fine grains joints. The Non Destructive Testing team of EMPA will participate to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biology of Liver and Pancreatic Development and Disease' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Aims: provide a cutting edge research training programme encompassing complementary approaches to the investigation of liver and pancreatic development and disease. Provide early stage researchers with a balanced mix of experience and skills in academic and industry based research. Give early stage researchers a set of transferrable skills which will improve their employment and career prospects. Objectives: 1) To provide a broad multi-disciplinary approach to liver and pancreatic development and disease which will ensure a solid foundation in research technology and methods. 2) To offer a number of multi-centre and cross-sector projects. 3) To organize regular meetings which will provide task-specific and complementary training in skills essential for career development. Implementation: 1) involvement of highly successful research leaders and groups (with expertise in different disciplines including systems biology and bioinformatics, developmental biology, genomics, genetics and epigenetics, cell biology, engineering and drug development) in design and running of this programme will ensure the cutting edge research methodology and multidisciplinary approach to training. 2) Each research project will involve minimum two partners. 3) Partners will alternate in organizing network meetings which will include laboratory courses, single-topic conferences and network workshops. 4) The experienced researchers recruited to the network will spend more time in the industrial setting and have more leadership training and responsibilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Very Efficient Deep Learning in IOT' (VEDLIoT).

assistant: **Innovation**

The ever increasing performance of computer systems in general and IoT systems, in particular, delivers the capability to solve increasingly challenging problems, pushing automation to improve the quality of our life. This triggers the need for a next-generation IoT architecture, satisfying the demand for key sectors like transportation (e.g. self-driving cars), industry (e.g. robotization or predictive maintenance), and our homes (e.g. assisted living). Such applications require building systems of enormous complexity, so that traditional approaches start to fail. The amount of data collected and processed is huge, the computational power required is very high, and the algorithms are too complex allowing for the computation of solutions within the tight time constraints. In addition, security, privacy, or robustness for such systems becomes a critical challenge.An enabler that aims at delivering the required keystone is VEDLIoT, a Very Efficient Deep Learning IoT platform. Instead of traditional algorithms, artificial intelligence (AI) and deep learning (DL) are used to handle the large complexity. Due to the distributed approach, VEDLIoT allows dividing the application into smaller and more efficient components and work together in large collaborative systems in the Internet of Things (IoT), enabling AI-based algorithms that are distributed over IoT devices from edge to cloud.In terms of hardware, VEDLIoT offers a platform, the Cognitive IoT platform, leveraging European technology, which can be easily configured to be placed at any level of the compute continuum starting from the sensor nodes and then edge to cloud. Driven by use cases in the key sectors of automotive, industrial, and smart homes, the platform is supported by cross-cutting aspects satisfying  securit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INTEGRATING ARMENIA INTO ERA: INFORMATION AND COMMUNICATION TECHNOLOGIES' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The INARMERA-ICT Project aims at reinforcing the cooperation capacity of the Institute for Informatics and Automation Problems (IIAP) of the National Academy of Sciences of the Republic of Armenia by providing the possibilities to improve its research activities in the areas of thematic priorities of the Framework Programme. Participation of IIAP in ERA-WIDE  Call was endorsed by the Armenian Government due to the important role it assigned to the institute in the transition of the country to innovative knowledge based economy, due to active participation in FP5, FP6 and FP7 projects, and the responsibility the institute bears in the development of ICT in Armenia and the region.To reach this objective, the Project consortium consisting of IIAP and three partners from Belgium, France and Hungary will carry out research assessment of IIAP, will organise training in FP7 and FP8 for IIAP scientists, and their research training in the latest methods in Information Technology, Cybernetics, etc. For networking and dissemination purposes workshops and summer schools will be organised in Armenia, while Armenian scientists will be able to attend events in Europe. Meantime from the start of INARMERA-ICT, four pilot projects will be organised between IIAP scientists and their colleagues in Europe, but also in Georgia, highlighting the regional aspect of the Project. The pilot projects will help Participants to identify bottlenecks of cooperation and find remedies; they will lay grounds for larger FP project proposals.The Strategy Experts Group will develop strategy for IIAP aiming at confirming its reputation as the leading regional ICT centre and turning it into a committed partner for European institutions in Framework Programmes. Project results and achievements will be analysed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Climate Change and Variability: Impact on Central and Eastern Europe' (CLAVIER).

assistant: **Concept**

Observational records show that the global climate is changing and ongoing changes are also visible in Central Eastern Europe. About 64% of all catastrophic events in Europe since 1980 can directly be attributed to weather and climate extremes. Climate change projections show even an increasing likelihood of extremes. Certainly negative impacts of climate change will involve significant economic looses in several regions of Europe, while others may bring health or welfare problems somewhere else. Within CLAVIER three representative Central and Eastern European Countries (CEEC) will be studied in detail: Hungary, Romania, and Bulgaria. Researches from 6 countries and different disciplines will identify linkages between climate change and its impact on weather patterns with consequences on air pollution, extremes events, and on water resources. Furthermore, an evaluation of the economic impact on agriculture, tourism, energy supply and the public sector will be conducted.This is of increasing importance for CEEC, which are currently facing a rapid economic development, but also for the European Union as e.g. Romania's and Bulgaria's high vulnerability from extreme events such as floods will impact not only the respective economic goals for joining the EU but also the EU solidarity fund. CLAVIER will focus on ongoing and future climate changes in Central and Eastern European Countries using measurements and existing regional scenarios to determine possible developments of the climate and to address related uncertainty.In addition, climate projections with very high detail will be carried out for CEEC to fulfil the need for a large amount of detail in time and space, which is inherent in local and regional impact assessment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Closing the European gap towards a large scale ex vivo platelet production built upon a silk-based scaffold bioreactor'.

assistant: **Concept**

The generation of ex vivo functional megakaryocytes (MK) and platelets is questioning current transfusion medicine exclusive reliance on blood donors to produce platelets. The demand for platelets is, in fact, in continuous rise, driven by an aging population, advances in medical procedures and even more aggressive cancer therapies, although the supply of blood donors continues to remain stagnant. Ex vivo platelet production systems have then emerged as a feasible supply that can moreover secure universal compatibility to avoid platelet refractoriness. If during the FET Open application we have proved that the platelet production ex vivo can be precision-tailored with the correct physical and biochemical environment, now with SilkPlatelet our consortium is looking forward to demonstrating the feasibility of an upscaled ex vivo production system. To bring then our technology from TRL4 to TRL6 we will increase the ex vivo platelet production capacity with media and stem cells aligned to GMP requirements for large-scale clinical transfusion. Our goal is to produce universal platelets particularly for patients with immune reaction to previous transfusions with HLA null platelets and patients with acute hemorrhage. At the core of our ?from lab-to-patients? roadmap, we will find both UNICAM proprietary technology to differentiate stem cells into MK precursors (natural source of platelets) and UNIPV disruptive bioreactor made of a silk-scaffold to mimic the bone marrow conditions. These will be then complemented by IGR long-term experience in iPSC and MK biology, and ISENET cell quality control contribute to the standardization of the platelet production pipeline and its validation and verification. Under the guidance of our experienced tech transfer officers, by the end of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The zona limitans intrathalamica as an organiser of diencephalic development', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The generation of the vertebrate brain relies on regionalisation of the neural plate through formation of boundaries. An important function of boundaries is to maintain the position of special groups of cells that are able to direct development of the neighbouring tissue. Such cell types form organisers and exert their action through secretion of long range signalling molecules. The formation of boundaries and their role in development of a forebrain region, the diencephalon, is still poorly understood. T he recent discovery of instructive activity of a diencephalic boundary, the zona limitans intrathalamica (ZLI), has raised new questions on its mechanism of action.To understand the role of the ZLI in the development of the diencephalon we plan to first, identify the genetic programme induced by ZLI activity in the neighbouring tissue. Thereafter, we will select among the newly identified genes those with predicted value as lineage tracers and use their promoters to drive transgenic expression of an inducible Cre recombinase. Induction of Cre activity in a reporter mouse line will allow for the identification of neuronal progenitors induced by the ZLI and the analysis of their contribution to diencephalic architecture.At the same time, some of the newly id entified genes will be tested for their function in diencephalic development by gain and loss of function experiments in chick and mouse. In addition to contributing to the understanding of the events that lead to the formation of the diencephalon, this re search will also complement my previous training in the transcriptional control of cell lineage commitment and development in the mouse, with important developmental neurobiology skills and the use of a new model system, the chick embryo. The resulting bro ad spect