RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Orthogonally Functionalized Binary Nanopatterned Polymeric Substrates for T cell activation and proliferation in Cancer Immunotherapy' in the context of a Seventh Framework call.

assistant: **Objectives**

Harnessing the power of the immune system to fight malignancies remains a challenging goal although important progress has recently been achieved. For example, cancer remission of terminal leukemia patients was accomplished with genetically modified autologous T cells (Dr. June, University of Pennsylvania, 2011). However, these adoptive T cell therapies are limited by the availability of target specific T cells that are extracted from each patient, expanded ex vivo, and transferred back to the patient. To extend cancer immunotherapies to clinics, the current T cell expansion technologies need to be improved to efficiently produce the large amounts of T cells that are required. To overcome this problem we propose the development of orthogonally functionalized binary nanopatterned polymeric substrates that will act as efficient artificial ‘T cell proliferation machines’. These binary nanopatterns will consist of gold and oxide nanoparticles that will be orthogonally functionalized with either anti-CD3 or anti-CD28, which are the biomolecules that trigger T cells and activate their expansion. These substrates will introduce an unprecedented fine control in the nanoscale that will certainly contribute to the understanding of the immune processes that remain enigmatic in spite of their fundamental role in the survival of species. The OFB-SCI project proposes a truly multidisciplinary and intersectorial research in the field of Cancer Nanotechnology with a clear ambition to transfer the knowledge acquired to the industry in the near-future facilitating the introduction of novel cancer immunotherapies in clinics. Overall, this project will offer a first class training experience to a promising young European researcher, Dr. Guasch, based on a broad and challenging yet feasible
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Control system implementation at the iasa microton' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

It is proposed that the applicant undertakes the implementation of the Control System of the 100KeV injector line for the Racetrack Microtron (RTM) at the Institute of Accelerating Systems and Applications (IASA). Emphasis is given to the successful importation/adaptation of the EPICS Control System and the related software development in this environment. This project will also serve as a pilot study to help define the detailed architecture for the entire control system for the RTM. Its links with industry and with other Community programmes are well defined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'New type of water and energy saving cleaning technique to improve the hygienic result'.

assistant: **Objectives**

Scientific objectives and approach:To develop a water saving technique for high pressure cleaning which- reduce the water consumption with 40%- allow individual adjustments of flow and pressure values to optimise hygienic cleaning- minimise the number of water droplets, which can distribute micro-organisms- decrease the number of micro-organisms with 25%- decrease the energy consumption with 20%The issue in this developing work is to resolve the following technical problems- how to optimise water energy for reduction of water consumption- how to adjust flow rate and pressure independently of each other- how to change the shape and size of the water drops in the water jet without exchanging the nozzleProblems to be solved:All over the world industries use high-pressure water cleaning to get rid of contamination, micro-organisms and bacteria's. In food-, pharmaceutical- and agriculturalindustries enormous amounts of water are used every day for different cleaning purposes. In many parts of Europe, and also all over the world, there is a lack of good quality water at a reasonable price. In this project we focus on improving the technique for high-pressure cleaning to reduce the water consumption and improve the hygienic cleaning result.Expected Impacts:The result will be a high pressure cleaning pump with trigless spray gun and possibilities to adjust water flow and pressure. The SME core group will exploit the RTD results and sell the new pump to food processing plants and other plants with high demands in Europe starting in the end of 2003. Dissemination/presentation of the product will be at EIMA Fair end of 2003. Major Deliverables - Milestones :- to reduce water consumption by 40% and improve cleaning efficiency.- to regulate flow rate and pressure.- to control the si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'European Stratospheric Balloon Observatory Design Study'.

assistant: **Innovation**

Following the findings of the H2020-funded ORISON project, we propose the design and development of a new European astronomical research infrastructure for stratospheric balloon-based telescopes. Our approach is to provide a versatile community-accessible observatory capable of covering unserved scientific needs, including those of star- and planet formation studies and exoplanet research. These are particularly associated with requirements for high spatial and spectral resolution far-infrared (FIR) observations, high sensitivity UV observations, and highly accurate visible light photometry. To a certain extent, these needs could also be addressed by space missions. A balloon infrastructure, however, will offer a more cost-efficient and flexible approach, allowing instruments more adaptable to evolving needs (exchangeable and less risk-adverse), longer overall observation times (possibility to refill cooling fluids), and larger mirror sizes (less severe launcher restrictions). So far, stratospheric telescopes, with the exception of SOFIA, have mostly served a single purpose and did not fly more than a few times. The proposed infrastructure, in contrast, will provide regular flights, allowing it to operate as a true observatory.The infrastructure will be prepared in two parts within the project:1) Conceptualization of the full distributed infrastructure with several flight platforms, including a suitable governance and operating structure for long-term operations and development. These will build upon a highly sensitive UV platform and lead to a next-generation FIR platform with unprecedented spatial resolution. A development roadmap will summarize the necessary development steps and funding needs.2) Technical demonstration of the manageability and safe recovery of a ver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Tribbles Research and Innovation Network' (TRAIN) under Horizon 2020.

assistant: **Objectives**

This proposal was developed in the context of the medical need to tackle  the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects described in the proposal will investigate regulators of these pathways with a focus on a recently described family of pseudokinases, namely tribbles proteins, which have a key role in controlling immunity, metabolism and cancer, and which here will serve as prototypical examples for integrative metabolocentric cancer research. Tribbles are envisaged to contribute directly to the development and progression of prostate cancer, the prognosis of which is substantially worsened in individuals with immuno-metabolic disease.We therefore propose a multidisciplinary research-training programme with an overall objective to uncover cell-specific aspects of tribbles-mediated control of immuno-metabolism and their impact on prostate cancer progression. We will approach this by integrating cell biology and sophisticated in vivo models of both immuno-metabolic disease and prostate cancer, complemented by specialist human disease biobanks, cutting-edge genomics approaches, plus a drug discovery pipeline. This will be carried out by an alliance of leading academic research groups and specialist SMEs with complementary backgrounds in inflammation, adipose tissue biology, tumourigenesis, genomics, translational models of human disease, medicinal chemistry and drug discovery. This will provide a unique opportunity for a cohort of PhD students to undertake Research Training at the interface of se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cancer-Osteocyte NeTwoRk Atlas' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Metastatic breast cancer claims the lives of more European women than any other cancer, and is an ever-growing problem in an aging global population that increasingly survives treatment of primary cancer. The most common site for metastatic breast lesions is bone, with 75% of patients experiencing pathological fractures, spinal cord compression or severe bone pain. Crosstalk between cancer cells and osteocytes, which make up more than 90% of our bone cells and form a complex sensing and signalling network throughout our bones, has recently been implicated in this process. As we now know that breast cancer cells are already present in the bone marrow by the time a primary tumour has been diagnosed, preventing growth of the metastatic colony is the most likely target for successful therapeutic development. A number of molecular mechanisms have been proposed, including by my team, to underly the hijacking of osteocyte signalling by breast cancer cells, but as the osteocyte network is buried deep within hard mineralised tissue, mapping signalling and sensation within it has eluded researchers for decades. CONTRA proposes to embark upon frontier research to provide a greater understanding of the key signalling underlying metastatic bone disease, using cutting-edge techniques to map the osteocyte networks at the tumour-bone interface at single-cell resolution for the first time. I will leverage my expertise in cancer-osteocyte crosstalk, and in vivo, in vitro and in silico modelling of the osteocyte network, to be the first to truly understand this under-studied area of the metastatic cascade.CONTRA has the potential to revolutionise drug development and treatment of metastatic bone disease by providing a leap forward our ability to study the under-explored role of the osteoc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrating Economic Regional Impact Models' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

With the ever-increasing turbulence of the modern global economy the need for better assessment of economic policy is imperative. National macroeconomic assessment has long been seen as one of the corner stones of good governance with all nations compiling vast amounts of data for analysis. What has not seen the same depth of analysis from Governments is the effect of economic policy on regions. This fellowship will develop the first fully integrated approach to regional economic impact analysis. This will be achieved by linking together two powerful models, the Econometric Input Output and the Computable General Equilibrium into a harmonised framework. This approach will seek to establish a bridge between the methods of calibration and estimation something not achieved to this point. To evaluate the performance of this new “technique” in impact analysis European Structural funds for both sectors and regions will be analysed. The model will provide the first and most comprehensive evaluative tool for the new Smart Specialisation agenda in line with Europe 2020. The three major objectives of the fellowship are, first the construction of a new integrated economic impact model. The second is an assessment of how the external “shock” of Structural funds affects the supply and demand relationships within a regions economic base. The final and most unique contribution of this fellowship will be the implementation of a new open source model capable of being utilised by all regions in Europe providing a lasting legacy from this work. The next programming period (2014-2020) is still under development, thus this work is most timely and will provide the best tool for the assessment of Smart Specialisation across regions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Speed of Adaptation in Population Genetics and Evolutionary Computation'.

assistant: **Concept**

Biological evolution has produced an extraordinary diversity of organisms, even the simplest of which is highly adapted, with multiple complex structures. Evolutionary computation has found that many innovative solutions to optimisation and design problems can be achieved by artificial evolution via random variation and selection.<br/>Despite the centrality of evolution to biology and the usefulness of evolutionary algorithms in optimisation, the dynamics of evolution are not well understood. Consequently, population genetics theory can only make quantitative predictions about short-term, simple biological evolution, and the design and parameter tuning of evolutionary algorithms is mostly done ad-hoc in a laborious and cost-intensive process.<br/>Both fields have studied the speed of adaptation independently, and with orthogonal approaches.  Our project brings together an interdisciplinary consortium of ambitious researchers from the theory of evolutionary computation and theoretical population genetics to synergise these complementary approaches and to create the foundation of a unified quantitative theory describing the speed of adaptation in both biological and artificial evolution.<br/>The transformative impact of this unified theory will lie in enabling long-term predictions about the efficiency of evolution in settings that are highly relevant for both fields and related sciences. Our approach will reveal how this efficiency is fundamentally determined by evolutionary and environmental parameters. Tuning these parameters will allow researchers from biology and computation to increase the efficiency of evolutionary processes, revolutionising applications ranging from evolutionary algorithms to experimental evolution and synthetic biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ENERGY-X: Transformative chemistry for a sustainable energy future' in the context of a Horizon 2020 call.

assistant: **Objectives**

The rationale of Energy-X is to develop the science as well as technology enabling a sustainable production of synthetic fuels for energy storage and as feedstock for the chemical and materials industry.Energy-X brings together interdisciplinary academic research (chemistry, physics, engineering and economic science) with cross-industrial technological expertise (chemical, engineering, utilities, mobility, agriculture) to provide a platform for future chemical energy conversion technology in Europe.Energy-X will contribute disruptive new science and technology enabling efficient conversion of solar and wind energy into chemical form and will combine this ambition with scale-up to industrially relevant conditions by integrating with European industry. Energy-X will also transfer the knowledge into two demonstration projects: manufacturing of carbon-neutral aviation fuels and decentralized production of fertilizers with no CO2 footprint.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sequence and Function Relationships in Long Intervening Noncoding RNAs' under Horizon 2020.

assistant: **Concept**

It is now clear that many intergenic regions in eukaryotic genomes give rise to a range of processed and regulated transcripts that do not appear to code for functional proteins. A subset of these are long (>200 nt), capped and polyadenylated RNAs transcribed by RNA polymerase II and collectively called long intervening noncoding RNAs or lincRNAs. The recent estimates are that the human genome encodes >10,000 distinct lincRNAs, many of which show tissue-specific expression and are frequently dysregulated in human disease, including neurodegeneration. Given the growing number of lincRNAs implicated in human disease or required for proper development, fundamental questions that need to be addressed are: Which lincRNAs are functional? How is functional information encoded in the lincRNA sequence? Is this information interpreted in the context of the mature or the nascent RNA? What are the identities and functional roles of specific sequence domains within lincRNA genes?Our main hypothesis is that many lincRNA loci play key roles in gene regulation during cell differentiation, both via functionally important transcription events and post-transcriptionally, through the combined action of multiple short sequence domains. We will test this hypothesis using three complementary approaches – comparative genomics, detailed perturbations in mammalian cells followed by quantitative molecular phenotyping, and high-throughput screens for sequences able to carry out specific functions.We propose an interdisciplinary approach combining computational, molecular and stem cell biology. Our methodology will be scalable, allowing us to tackle completely uncharacterized long RNAs and eventually zoom in and study their individual bases. Upon successful accomplishment of the program, we will de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Untangling the pathophysiology of congenital disorders of glycosylation affecting the OST complex'.

assistant: **Innovation**

Congenital disorders of glycosylation (CDG) are a group of over 100 inherited disorders characterised by defective glycosylation of proteins and lipids. Although the phenotypic and genetic characteristics of CDG as a whole are well established, their pathophysiology is poorly understood. In addition, the phenotype of affected patients is extremely variable, with dramatically different clinical presentations often appearing in patients with mutations in the same gene. I plan to investigate the link between pathogenic mutation and phenotype using recent advances in omics technologies, with a focus on the regulation of genes implicated in the pathophysiology of CDG.Firstly, using transcriptomics and epigenomics, I will identify the mechanism by which mutations in homologous genes encoding subunits of the oligosaccharyltransferase (OST) complex cause divergent phenotypes, thought to be due to differences in the regulation of tissue-specific transcription. The primary model for these studies will be the MAGT1 gene, mutations in which can lead to either a severe developmental disorder (MAGT1-CDG) or an isolated primary immune deficiency (XMEN). Secondly, using glycoproteomic techniques, I will study the proteins most affected by aberrant glycosylation in CDG affecting the OST, thereby characterising their pathophysiology in both patient-derived and modified cell lines. findings will be further investigated using targeted techniques such as LC-MS/MS. In summary, this study will simultaneously provide valuable insight into both the pathophysiology of CDG and the functional regulation of the OST complex, an understudied aspect of cell biology.