RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Epigenomic Reprogramming of Adipose Tissue Function and Energy Metabolism in Type 2 Diabetes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Obesity is associated with adipose tissue dysfunction leading to the onset of several pathologies including type 2 diabetes (T2D). The mechanisms underlying the development of obesity and T2D include the hypertrophy and/or hyperplasia of adipocytes and adipose tissue inflammation together with an altered secretion of adipokines. However, the explanation of why individual obese (and some non-obese) humans differ in their susceptibility to develop T2D is still an issue that is currently not sufficiently addressed. This susceptibility to T2D is mainly associated with environmental factors. One link between environment and disease is epigenetics influencing gene expression and subsequently organ dysfunction. Epigenetic modifications in adipose tissue have been proposed to influence the susceptibility to T2D. However, the epigenomic mechanisms underpinning adipose tissue dysfunction are poorly known. In search for epigenomic modifiers that control adipose tissue function and also impact on T2D pathogenesis, we have recently identified the transcriptional coregulators GPS2 (G-Protein Pathway Suppressor 2) and KDM6B (Histone Lysine Demethylase 6B, also called JMJD3) as strong candidates..Our hypothesis is that the clinically documented dysregulation of GPS2 (down) and KDM6B (up) expression and function during obesity leads to the closely linked epigenetic and transcriptional reprogramming of adipocytes and adipose tissue-macrophages, thereby enhancing the susceptibility to metabolic and inflammatory disturbances and the progression towards T2D. We propose here to test this hypothesis using the combination of unique mouse models, genome-wide molecular and epigenomic analyses and human studies to dissect the epigenomic functions of GPS2 and KDM6B in adipose tissue, aiming at ide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Self-organisation across the scales in early mammalian development', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

A defining feature of multi-cellular living systems is the capacity to break symmetry and generate patterns through self-organisation. Our project aims to understand the design principle of multi-cellular self-organisation, using a well-suited model system: early mouse embryos. In mammals eggs lack polarity and symmetry is broken during early embryogenesis, which results in segregation of three cell lineages in the blastocyst. Progressive expansion and coalescence of fluid-filled spaces form the blastocyst cavity that segregates the cavity-facing lineage from the rest. Despite extensive gene expression studies, how molecular and physical signals are dynamically coupled for self-organised blastocyst patterning remains poorly understood. We aim to identify the mechanisms of feedback between cell polarity, mechanics (contractility, adhesion, pressure) and fate operating across sub-cellular to whole organismal scales. For this, we adopt a unique set of strategies that integrate biology and physics: advanced live-imaging, quantification of molecular and physical parameters to integrate into lineage maps, reduced systems to establish physical models, and spatio-temporally controlled manipulations for functional validation of those models. We will build up complexities. At the single-cell level, we will study de novo assembly of the apical domain in relation to cell contact and cortical contractility. For inside-outside patterning, we aim to dissect the coordinated signalling between cell position and fate specification. Furthermore, we will study how fluid cavities, a yet unexplored parameter, contribute to cell sorting, apical polarisation and fate specification through generation of pressure and contact-free cell surfaces. Ultimately, we will reconstitute embryogenesis in s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The establishment and function of dorsiventral boundaries in plant organs' to be submitted under Seventh Framework.

assistant: **Abstract**

The coordination of cellular behaviour that results in development involves the synchronization of many distinct patterning processes. A prime example of coordination at different levels is the process of lateral organ development. Firstly, a positioning system ensures that new organs initiate at the right locations. Secondly, gene expression must be patterned so as to define the different tissue types correctly. Lastly, specific patterns of localized growth must occur such that the organ develops to the correct size and morphology. How are these distinct processes regulated and what signals coordinate their patterning?By building on my recent work, this proposal aims, for the first time, to build an integrated understanding of how these distinct patterning processes arise and coordinate with one another, in the model plant species Arabidopsis thaliana. The proposal utilizes and extends the multispectral live-imaging techniques I pioneered as a postdoc and combines this approach with state-of-the-art transcriptomics and perturbation methods. Specifically, I aim to understand the regulatory links that coordinate dorsoventral patterning, cell polarity and morphogenesis at the shoot apical meristem (SAM) and during lateral organ development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimized pre-treatment of fast growing woody and nonwoody Brazilian crops by detailed characterization of chemical changes produced in the lignin-carbohydrate matrix' (LIGNODECO).

assistant: **Concept**

Biomass production costs are low in Brazil compared to other parts of the world, due to proper climate and advanced forest and agricultural technologies. The productivities of elephant grass (Pennisetum spp; 30-45 t/ha/yr bone dry) and eucalypt crops (20-30 t/ha/yr bone dry) in Brazil are amongst the world largest, with good perspectives of growing even further. Thus, Brazil presents great potential for application of the Biorefinery concept. It is our contend that production of biofuels and bio-products from lignocellulosics is better fit to existing pulp manufacturing facilities, to take advantage of existing infrastructure and the possibility of process integration. The objective of the LIGNODECO proposal is developing pre-treatments for optimized deconstruction of hybrid eucalyptus clones and elephant grass biomass into its components aimed at production of biofuel (bioethanol and biogas) along with specialty grade pulps and other bio-products, strongly emphasising feedstock selection and use of advanced analytical tools. This will be accomplished by collection/selection of feedstocks for deconstruction studies, optimized pre-treatments for woody and nonwoody materials, physical/chemical characterization of the pre-treated materials, and tie in between pre-treatment and industrial use of lignocellulosics. LIGNODECO incorporates innovations such as tailor-made modifications of existing technologies for paper-pulp industry, mild biotechnological pre-treatments based on biocatalysts, modern analytical techniques for characterizing lignin, hemicelluloses and cellulose, utilization of Brazilian fast-growing woody and nonwoody crops as feedstock for future biofuels, novel high value-added cellulosic pulps from eucalypt and grasses for specialty papers, integrated use of x
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modelling opportunities and limits for restructuring europe towards sustainability' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The project framework of MOSUS is set by key agreements for the future sustainable development of the European Union. MOSUS will apply an integrated ecological-economic simulation model to quantify the interrelations between socio-economic driving forces and the state of the environment. The analysis uses a multi-country, multi-sectoral macroeconomic framework, including trade flows within Europe and between Europe and all otherworld regions. The model will be the first such tool to directly integrate comprehensive biophysical data (materials, energy, land use data, and greenhouse gas emissions) in simulations to the year 2020, putting them in relation to indicators of social and economic development. MOSUS will formulate EU development scenarios and evaluate the economic and social impacts of key environmental policy measures and will present quantified policy recommendations for responding to environmental challenges and changes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Access to research environments and advanced processing facilities in microwave electronics, photonics and nanotechnology at the MC2 facility' to be submitted under Sixth Framework.

assistant: **Abstract**

Access is offered to advanced micro- and nanotechnology device processing environments for microwave and photonic devices and for nanotechnology at the Department of Microtechnology and Nanoscience (MC2) at Chalmers University of Technology in Göteborg, Sweden. The laboratory provides means to develop process steps, process sequences, and components in small/medium quantities.In 1240m2 clean-room area more than 150 tools are available, including two e-beam lithography systems (one of which is a JBX 9300FS from JEOL with a spot diameter of 4nm and a minimum feature size of below 10nm), silicon processing on up to 150mm wafers, III-V and wide bandgap processing, molecular beam epitaxy, CVD and dry etching systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Stimuli-Responsive Mechanically Interlocked Peptide Rotaxanes for Biomaterials and Biosensing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Mechanically interlocked molecules (MIMs) feature mechanical bonds, which link multiple distinct components together allowing free movement between them without dissociation. This makes MIMs perfect candidates for artificial molecular machines, and earned them the Nobel Prize in Chemistry 2016. Over the last 30 years, MIMs have been applied in diverse areas from switchable catalysis to smart materials. However, they have so far only found limited use in biomedicine, due to the often lengthy synthesis and poor solubility in biological media. Directly addressing these challenges, we will use Natures own building blocks (i.e. peptides) to construct stimuli-responsive MIMs for use in bioapplications. Rotaxanes are a class of MIM resembling dumbbells, with a macrocyclic ring encircling the axle. We will use bioactive peptides as the rotaxane axle (making them intrinsically biocompatible MIMs) whose bioactivity will be initially silenced via obstruction of the encircled stimuli-responsive macrocycle, which acts as protective armour and stabilises the peptide. Upon application of a stimulus (e.g. light irradiation), self-immolative cleavage of the macrocycle occurs, liberating the free peptide. Hence, light acts as a stimulus to turn-on the bioactive response of the peptide on-demand. We will use this to design advanced biosensing systems for stimuli-responsive MMP2 cleavage of the peptide sequence PLGLAG. Further, we will develop beyond state-of-the-art photopatterning methods for cell adhesion, using the integrin-binding RGDS peptide sequence as our rotaxane axle. Using the high spatiotemporal control of light, we can turn on cell-adhesion where desired via self-immolation of the macrocycle using light irradiation. This action represents a precise, high-resolution method for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cooperative Synthesis by Molecular Deconvolution' under Horizon 2020.

assistant: **Concept**

The past six decades have seen awe-inspiring progress in the science of synthesis. In academia, the assembly of complex molecules (natural products) still poses a challenge, but is no longer a limitation. Yet, application of natural products in industry is still limited. This limitation is reflected by a lack of novel lead structures with a new mode of action — one of the main challenges pharmaceutical industry faces today. With complexity still being a challenge but no longer the limitation, natural products and their unique structures are now ideally suited to fill this gap. However, “target oriented synthesis” (TOS) still dominates the synthetic community, but is not suited for structure diversification. This imposes a poor “return on investment” (ROI) to natural product research in industry. The diminished ROI of TOS is owned to tailor made synthetic routes, strictly applicable to a single molecule with no flexibility, and thus disproportionally increasing time and financial efforts in the search for new lead structures. In this research proposal, the applicant devises an alternative strategic concept termed “Cooperative Synthesis by Molecular Deconvolution” (CoSyMoDe), providing an alternative to TOS, and thus serves as a versatile tool for lead structure discovery. In contrast to TOS, CoSyMoDe targets the most complex congener (alpha) in a set of natural products. All other congeners are obtained by synthetic deconvolution of alpha, rendering the overall process more facile, additionally providing access to a whole set of targets, and thus improving the ROI. To showcase the versatility of CoSyMoDe we have picked one of the most challenging, bioactive, and prominent set of target structures, the taxane diterpenes. Amongst them “cyclotaxanes”, are most complex, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ancient Music Beyond Hellenisation' to be submitted under Horizon 2020.

assistant: **Abstract**

From medieval times, Arabic as well as European music was analysed in terms that were inherited from Classical Antiquity and had thus developed in a very different music culture. In spite of recent breakthroughs in the understanding of the latter, whose technicalities we access not only through texts and iconography, but also through instrument finds and surviving notated melodies, its relation to music traditions known from later periods and different places is almost uncharted territory.The present project explores relations between Hellenic/Hellenistic music as pervaded the theatres and concert halls throughout and beyond the Roman empire, Near Eastern traditions – from the diatonic system emerging from cuneiform sources to the flourishing musical world of the caliphates – and, as far as possible, African musical life south of Egypt as well – a region that maintained close ties both with the Hellenised culture of its northern neighbours and with the Arabian Peninsula.On the one hand, this demands collaboration between Classical Philology and Arabic Studies, extending methods recently developed within music archaeological research related to the Classical Mediterranean. Arabic writings need to be examined in close reading, using recent insights into the interplay between ancient music theory and practice, in order to segregate the influence of Greek thinking from ideas and facts that must relate to contemporaneous ‘Arabic’ music-making. In this way we hope better to define the relation of this tradition to the ‘Classical world’, potentially breaking free of Orientalising bias informing modern views. On the other hand, the study and reconstruction, virtual and material, of wind instruments of Hellenistic pedigree but found outside the confinements of the Hellenistic ‘h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The three-dimensional Magnetic Structure of solar Filaments and Prominences' to be submitted under Seventh Framework.

assistant: **Abstract**

Solar filaments are prominent cold and dense structures of plasma suspended in the hot corona. They are called prominences when observed above the solar limb. Despite they were probably the first solar features to be observed, the magnetic structure of solar filaments is still largely unknown, being their determination a fundamental problem for Solar Physics. The reason is the lack of chromospheric observables able to provide binding information for the magnetic field. Therefore, though there are two main proposed models, namely sheared-arcade and twisted flux-rope models, due to the lack of observational constraints it is unclear what is the filament most probable magnetic configuration. High-spatial resolution observations have revealed that filaments are also highly structured at very small scales.  Remarkably, most solar filaments erupt, giving rise to coronal mass ejection. Thus, the understanding of solar filaments is also important for space-weather forecasting. To infer their magnetic structure it is crucial to observe the formation and evolution of solar filaments in the Photosphere and in the Chromosphere, in polarized light, and at the highest spatial resolution. We propose to observe solar filaments with the Tenerife Infrared Polarimeter (TIP-II) installed at the  GREGOR ground-based  1.5-meter telescope in synchrony with the Hinode space-based observatory. I will use TIP-II to observe the 1083.0 nm spectral region containing a photospheric line and the chromospheric He I 1083.0 nm triplet. This line is sensitive to atomic level polarization and to the joint action of the Hanle and Zeeman effects. Thus, it is ideal for determining a wide range of field strengths in prominences. The data will be analyzed using state-of-the art inversion algorithms. Finally, H
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'REgenerative Stem cell therapy for STroke in Europe' (RESSTORE).

assistant: **Concept**

Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke recovery and patients quality of life. RESSTORE European multicentre randomised phase IIb will explore, for the first time, the efficacy (functional recovery) and safety of intravenous infusion of allogenic adipose tissue derived mesenchymal stem cells (ADMSCs) in 400 stroke patients. Therapeutic effects of ADMSCs will be assessed and monitored in patients using clinical rating scales, multimodal MRI and novel blood biomarkers. Additionally, the societal value and cost-effectiveness of ADMSCs-based regenerative therapy will be evaluated through health economics and predictive in silico simulations.  Complementary ancillary animal studies will support the clinical trial by defining i) if the treatment response can be further enhanced by intensive rehabilitation, ii) the contribution of co-morbidities and iii) the mechanism(s) underlying the therapeutic effect.The European regenerative therapy capacities (France, Spain, Finland, United Kingdom and Czech Republic), developed in RESSTORE will cover the full value chain in the field (large scale GMP cell production, clinical testing, biomarkers discovery, understanding of the restoring mechanisms, modelling, biobanking, economic studies, exploitation and communication plan). RESSTORE will thus surely contribute, together with the workforce trained in the context of the programme, to improve its public and private (SME) competitiven