RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Technological Perspectives of the Multimedia Home Platform' to be submitted under Fifth Framework.

assistant: **Abstract**

The objective of this proposal is to explore the technological perspectives and social implications of the Multimedia Home Platform (MHP). From a technical point of view, the resource model of MHP compliant set-top boxes, or personal workstations, limits the design freedom in specific, yet undefined, ways. From a social perspective, the important factor is the consumer. The everyday consumer requires a different approach than, for instance, a typical PC-user. This proposal addresses both the implications from the design spaces, as given by the unique constraints of the MHP, and the implications concerning the interface design under special consideration of the usability aspects.Work description:The project can be broken down into two distinct phases. In the first phase, the MHP standard is analysed to identify both the conceptual and the technological levels of the standard. The second phase includes the definition and implementation of a prototype using a sample application. The prototype is tested within an educational and retail consumer environment. One of the main problems with the MHP is the lack of an appropriate interface. During the course of this project, the aim is to define a standard interface framework for applications. As opposed to most current attempts at digital TV interface designs, the project consortium will not orientate itself on the PC-platform. Studies have shown that the greatest market opportunities lie with the users that remain sceptic of PCs and/or the Internet. The main criteria for consumer applications are: an easy to use interface, which is integrated into the existing TV offering; the availability of the application; low prices, which should be based upon the necessary new business models; the external (secure) hosting of personal data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Tactile Manipulation' under Seventh Framework.

assistant: **Concept**

TACMAN addresses the key problem of developing an information processing and control technology enabling robot hands to exploit tactile sensitivity and thus become as dexterous as human hands. The current availability of the required technology now allows us to considerably advance in-hand manipulation. TACMAN's goal is to develop fundamentally new approaches which can replace manual labor under inhumane conditions by endowing robots with such tactile manipulation abilities, by transferring insights from human neuroscientific studies into machine learning algorithms.<br/>TACMAN will provide an innovative new technology that is key for bringing industrial manufacturing back to Europe. Consider the case of the iPhone, where most mechanical manipulation of the major components is achieved by manual human labor under terrible work conditions and not by advanced industrial robots--despite that millions of iPhones are industrially assembled per month. The reason for this absence of appropriate automation is the lack of manipulation skills of current robots.<br/>Commercially available robotic hand-arm systems move more accurately and faster than humans, and their sensors see more and at a higher precision--even the smallest forces and torques can be detected. Despite these impressive sensori-motor abilities, current robots are terrible at manipulation when compared to humans. Neuro- science provides a clear reason for the superiority of human hands: During manipulation, humans make substantial use of the data from tactile sensors, i.e., the information obtained through the feeling in the human's fingers. Robot hands are lacking this key ability! Hence, the rationale of TACMAN is that this performance gap in manipulation ability can be filled by (1) making such tactile sensory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synthesis of nicotine derivatives using solid supported reagents' under Fourth Framework.

assistant: **Concept**

Research objectives and content The nicotine is a natural alkaloid with high complex physiological activity. It is widely accepted that nicotine and its agonists could be used for the treatment of Alzheimer'disease, Parkinson's disease and as ansyolitic, antidepressive and schizophrenic therapeutic agents. The low availability of compounds structurally related to nicotine is a serious obstacle for structure activity relationships. Therefore, a novel total synthesis based on the use of polymeric supported reagents should allow the preparation of a large number of similar nicotine derivatives in a automatic fashion. For example, the polymer supported perruthenate (PSP), prepared by the methodology develop by the group of Prof. S.V. Ley, already successful applied in the synthesis of chemical libraries of other natural products. Based on these results we propose here the use of this reagents in two steps of a synthesis of nicotine derivatives based on solid supported reagents. Training content (objective, benefit and expected impact) I consider that the University of Cambridge it is now one of the most important European research centers in Organic Chemistry. During my training stay there, under the supervision of Prof. Steven V. Ley, I expect to improve my knowledge and experience in Synthetic Organic Chemistry: At the moment I have carried out research directed to methodologic aspects and would gain very much by working on a total synthesis project. Links with industry / industrial relevance (22) The understanding of the structure/activity relationship of nicotine and their af antidepressive properties are of great relevance for medicine and the pharmaceutical industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering co-translational protein folding, assembly and quality control pathways, in health and disease' in the context of a Horizon Europe call.

assistant: **Objectives**

The majority of cellular proteins do not function alone; rather acting together to achieve concerted functions. Despite the prevalence of protein complexes, little is known of the mechanisms that ensure their correct folding and assembly in the crowded cytoplasm. The importance of the folding challenge is underscored by the growing number of misfolding diseases, often characterized by aggregation of lonely, unassembled protein-subunits. At the critical intersection of synthesis and folding, the ribosome is emerging as a hub, guiding the polypeptide-chain interactions with targeting factors, modifying enzymes and folding chaperones. We have recently discovered that even the final step of folding, the assembly into complexes, is coordinated with translation. To capture co-translational events, in vivo, we developed a ribosome profiling approach. This approach revealed that emerging polypeptide-chains are constantly engaged by their partner subunits, protecting them from misfolding (Shiber et al., Nature 2018). However the mechanisms regulating co-translational assembly pathways remain largely obscure. In this proposal, we aim to elucidate co-translational protein folding and degradation mechanisms, in health and disease. We will: (i) Identify and characterize novel co-translational degradation pathways, by targeting ribosomes synthesizing misfolding-prone subunits. (ii) Elucidate the conformational, energetic and kinetic parameters directing folding and assembly, at the atomic level, by molecular dynamics (iii) Develop RiboFriend a single-molecule in vivo approach to elucidate the interplay of chaperones, degradation and assembly factors, during synthesis. Our collective preliminary results strongly support the feasibility of this proposal. The ability to capture co-trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi parity interactive multimedia conferencing services' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

There is a great possibility that multimedia, multiparty communication will become a key factor in the success of many parties, including information technology providers, telecom operators, service providers and end users. It will be able to improve the quality of work at reduced costs. In the long term, multiparty communication is expected to have an impact in homes for applications such as education, leisure, and interactive group games, among others.Current use of multimedia is largely limited to standalone implementation or to a limited use of communication capabilities. The main commercial applications are found in the areas of CBT, kiosks, video telephony and desktop conferencing. In all these areas, users find insufficient network inter-working capabilities, insufficient availability of multiparty services and insufficient effective tools for multimedia communication.The main objective of the MIMICS Project is to provide an innovative hardware and software platform for multiparty communication. In particular, the system will provide the hardware and software for the management of Multipoint communication. The hardware will include user terminals and Multipoint Control Units (MCUs) which will fully conform to the T.120 series of standards. The software modules will include APIs and Application Services. In addition, the Project aims to experiment with the creation of service centres that offer multimedia conferencing services both to generic users who simply need communication facilities and to specialised users.It also aims to experiment with the use of the hardware and software platform in two trial applications: An Emergency Management System will be experimented with and validated in regard to the provision of civic services in two field trials, one in Italy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Robot system for pipe inspection and repair' (ROSPIR), addressing dissemination and exploitation.

assistant: **Impact**

Pipe networks provide an important infrastructure for the transport of liquids in industrial production. It is thus very crucial for the reliability andsafety of production plants to monitor the pipe system. In case of detectedleakages it would be advantageous to quickly repair the pipe system withoutmajor interruptions of the production. For this purpose a new generation ofmobile inspection and repair robots, based on advanced microsensor systems, is to be developed. Departing from an already existing repair robot product of thecompany Streicher Maschinenbau, this project will investigate innovativeimprovements to increase the robot's capabilities as well as the applicationareas. - by the use of micro-sensors to navigate and accurately position therobot for inspection and repair, as well as to monitor the actual status of therepair process, - by implementing a robust, but very flexible milling cutter toprepare the leakage area for the repair, - by adapting the robot for navigationand uninterrupted operations in curved pipes of small diameter beyond adistance of 100 m, - by pipe failure recognition, based on data base and expertsystem technics, - by remote access to the service station via modem link to a central station in order to provide technical assistance in robot operations byspecialists. As Streicher GmbH has its main emphasis on manufacturing, theparticipating SMEs have not an adequate R&D-infrastructure to perform thesenecessary development efforts and product innovations in-house. The envisagedimprovements would significantly increase the application spectrum of piperobots in industrial production environments and thus support the SMEs positionin the market. The available experiences of the partners in similar micro-robotprojects encourages the team to judge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'On-demand Non-hermitian TOPology' in the context of a Horizon 2020 call.

assistant: **Objectives**

Physical materials can display a topological order, i.e. a collective organization characterized by a discrete number or “topological charge”. Because the integer nature of this charge must be preserved throughout the structure, topological order is intrinsically immune to perturbations and the system is said to be topologically protected. Recently, the replication of topological protection in optics has raised the interest of the scientific community for its potential ability to overcome fundamental problems—like the influence of imperfections intrinsically present in nanoscale-fabrication processes, which currently preclude the development of multiple photonic technologies. Yet, at optical frequencies the weak response of materials often precludes a topological approach such that even careful designs can only partially deliver the expected protection. In contrast to material properties, gain and loss can be easily manipulated in optics. While the exploitation of non-hermitian systems—with non-conserved energy—recently enabled the formation of topological order in wave physics, it simultaneously questioned our theoretical understanding of topology and offered a large variety of new degrees of freedom that are yet to be explored.Here I suggest exploiting the versatility of optical gain-loss to imprint topological order “on-demand” onto otherwise topologically trivial systems. Through non-uniform spatial distributions of optical gain and loss I intend to demonstrate theoretically the formation of topological protection in random systems and implement my predictions in existing experimental platforms. In sharp contrast with the conventional conception of topology that relies on careful and rigid designs, this project will explore the possibility to engineer topology throu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Priority medicines for the citizens of Europe - high-level invitanional conference during the Netherlands presidency'.

assistant: **Concept**

The Netherlands proposes to hold a high-level conference on Piority Medicines to address priorities for a research agenda and policy measures to resolve the pharmacological treatment gaps in an expanded Europe. This conference (November 18, 2004), its prep aratory work and follow-up aim to support the G-10 process: innovation for the European pharma industry for the benefit of the patient. Financial back ground for the member states: public spending on pharmaceuticals needs to be targeted in the best interes t of public health. What is the problem? Pharmacological gaps exist in the treatment of patients. For many conditions, pharmaceutical interventions are not available or provide marginal benefits, and many beneficial interventions are burdened with adverse effects. We need a robust methodology to identify these gaps and prioritize them. NL commissioned a study by WHO. WHO will present their methodolgy at the conference. WHO will also present a list of conditions that need further research and policy measures . From basic research ('upstream') to practical and policy incentives. The Dutch Medical Research Council will present preliminary results of an inventory (SSA) of corresponding national research programs in view of establishing an ERANet. Special attentio n for the new member states. The EIB will explore the options for EIB/EIF involvement in the follow-up phase. Stakeholders (industry, doctors, mutualities, ethicists, patients, others) will present position papers and views. Parliamentarians will be invite d. The conference aims to create a shared vision that is politically and scientifically relevant, on the nature of the problems and on possible ways forward. Recommendations will be addressed to policy makers (Commission, member states), the EIB, industry and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Systematic exploration of peroxisomal structure and function', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Peroxisomes are ubiquitous and dynamic organelles that house many important pathways of cellular metabolism. This key organelle propagates cellular signals for differentiation, development and metabolism, and thus it is no surprise that a large number of diseases, including metabolic disorders, have been linked to peroxisomal dysfunction. Despite the importance of peroxisomes many fundamental questions remain open. For example, we do not know the entire proteome of peroxisomes, the extent of their metabolic functions, how peroxisomes change to meet cellular requirements or how they interact and communicate with other cellular organelles. In this proposal we suggest to employ our expertise and unique toolsets, successfully applied in the study of whole organelles, to shed new light on peroxisomes as a cellular unit – a PeroxiSystem. We propose to combine state-of-the art high content tools with mechanistic studies to uncover new peroxisomal proteins under a variety of growth conditions (Aim1), map the functions of unstudied peroxisomal proteins using both systematic and hypothesis driven approaches (Aim 2) and unravel how peroxisomes communicate with other organelles (Aim 3). To perform these studies we will build on expertise attained during an ERC StG: combining high throughput genetic manipulations of yeast libraries alongside high content screens. Importantly, we will try to bridge the knowledge gap in peroxisomal biology by creating new tools that can be applied to this unique organelle. Our findings should make an important step towards an unprecedented, thorough and multifaceted understanding of peroxisomes, their cellular geography and roles as well as their regulation when presented with various metabolic conditions. More broadly, the approaches presented here c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Nanoparticle-based electronic biosensor for diagnostics of cardiovascular disease'.

assistant: **Innovation**

Insulin resistance, the key feature of the metabolic syndrome, not only causes type 2 diabetes but also gives rise to its deadliest complications - the cardiovascular disease. A key factor in the development of insulin resistance is the accumulation of triglycerides in liver and muscle, a process that seems to be highly regulated. NACARDIO is a multidisciplinary project aiming to develop and commercialise a nano-biosensor technology, capable of analysing extremely small amounts of protein in small sample volumes. The technology can be used to quantify proteins involved in lipid storage to investigate if any of these proteins are potential biomarkers for the development of insulin resistance and cardiovascular disease. The sensor technology is based on single electron tunnelling (SET), a phenomenon well explored for low temperature applications. State of the art nanofabrication utilising metallic nanoparticles now make this technology platform available for room temperature operation. SET-technology provides unique possibilities for biosensing. Direct electrical detection can be made with sensitivity greater than for any other existing or proposed technique. To achieve the goals of NACARDIO, extensive multidisciplinary work addressing questions at the interface between nanotechnology, physics, electrical engineering, surface chemistry, biotechnology and medical sciences will be performed. Frontline experimental approaches encompassing peptide-stabilised gold nanoparticles, electron-beam lithography, nano-imprint, molecular self-assembly, engineered antibody-fragments, protein expression and fluidic simulations will be employed to fabricate the sensor and ensure biological functionality and usability. The efforts will result in a technology that not only revolutionises ca