RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Linking Brain Activity to Selective Attention at a “Cocktail Party”: Enhancing Performance through Top-Down Modulation of Sensory Processing'.

assistant: **Concept**

The ability to selectively pay attention to a particular stream of input in the environment and to ignore competing irrelevant sounds is of utmost importance in daily life. This challenge is epitomized by the well-known “Cocktail Party Problem”, which has fascinated psychologist, neuroscientists, engineers and computer scientists for decades. Yet, to date much remains unknown about the neural basis underlying this important capacity. Moreover, performance on this important cognitive task varies greatly across individuals and under different environmental conditions, and attention is also known to ‘wander’ and fluctuate over time.The current proposal is aimed at linking neural activity to behavior in a “Cocktail Party”-like situation, and to understanding the factors underlying variability in selective attention performance. Using non-invasive neurophysiological recordings in humans, I will test the hypothesis that top-down modulation of sensory processing is directly linked to selective attention performance and can explain variability in performance across individuals, stimulus-conditions and over time. I will further investigate the effects of neurofeedback training on top-down sensory modulation and the impact such training has on performance on selective attention tasks. The use of neurofeedback in this framework introduces a new approach for probing the attentional system and studying its operations, and will also contribute to improving currently available training regimes for enhancing attentional performance.Overall, this research project will afford new perspectives and a deeper understanding of the neural basis of selective attention behavior and the “Cocktail Party” problem. Its results will also have substantial clinical implications for studying attentional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'In silico modeling of multi-domain proteins in biological condensates' to be submitted under Horizon Europe.

assistant: **Abstract**

Neurodegenerative disorders are one of the leading causes of disabilities and death in elderly populations worldwide. To this date, no established treatment can either prevent or slow down the progression of these diseases. Their occurrences and progression are strongly correlated with insoluble biological condensates composed of nucleic acids and proteins, where the latter are multi-domain proteins with both folded and disordered domains. The formation and the existence of biological condensates can be described through a combination of density (e.g., liquid-liquid phase separation) and network (percolation) transitions. These phase transitions are highly context-dependent (pH, temperature, etc.) and composition-dependent, i.e., the presence of other biopolymers, where these system variations can either enhance or suppress transitions or have a profound effect on the material properties of condensates formed. Currently, we lack computational approaches that can account for such system variations and predict the phase behavior of biological condensates. In this project, I will develop for the first time a quantitative computational model that will enable scanning a large chemical space, as well as, be temperature-sensitive. Next, I will use this model to identify the role of folded and disordered domains in the formation of condensates for two protein families related to amyotrophic lateral sclerosis, frontotemporal dementia, and autism spectrum disorder through large-scale molecular dynamics simulations. Lastly, I will deliver a microscopic understanding of how certain system variations are linked to neurodegenerative diseases, e.g., pH, the presence of other biopolymers, and changes in protein sequence affect the properties of biological condensates. I will carry out
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Interstellar Chemical Evolution: Probing HCN and HNC Formation and Destruction on Icy Surfaces with Computational Chemistry' in the context of a Horizon Europe call.

assistant: **Objectives**

HCN and HNC are routinely used by astronomers to trace temperature and dense gas regions in galaxies, where stars and planetary systems form. They are key precursors of complex species, including prebiotic molecules like amino acids and nucleotides. While their gas-phase formation and evolution are well understood, their formation and destruction paths on interstellar ices remains largely unchartered territory.The aim of this proposal is to remedy this knowledge gap by investigating the formation of HCN and HNC through CN radical hydrogenation on interstellar water and CO ices, as well as their destruction paths using state-of-the-art computational chemistry and astrochemical modelling. Including, in all cases, their deuterated counterparts. It also presents an opportunity to study the interaction of CN radicals with ice surfaces, which can occur either through physisorption or hemibonding on both types of ices. The four primary objectives of this proposal are: (i) to explore the CN to water and CO ice binding energy distribution as well as the dominant binding modes, (ii) to quantify the hydrogenation reactions of CN with atomic and molecular hydrogen forming HCN and HNC, as well as other possible hydrogenation products due to the hemibonding interactions, (iii) to investigate the destruction of the products in the previous point resulting from further hydrogenation reactions, and finally, (iv) to calculate the rate constants, including quantum tunnelling, and implement these in the UCLCHEM astrochemical model to assess the importance of surface chemistry in two specific cases: the shocked region L1157-B1 and the NGC1068 galaxy.The novelty of this proposal lies in the combination of computational chemistry and astrochemical modelling to unveil the ice-surface formation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Social Economy Transition Skills' (SETS) targeting Horizon Europe.

assistant: **Abstract**

SETS Project aims at developing, testing and disseminating suitable skills development programmes and training modules, to foster the Green and Digital transition of Social Economy Organisations (SEOs). The project activities will also prepare, through a specific ICT-driven impact assessment & management methodology, future scale-up of the project outcomes through other funds (Cohesion Funds, EIT, Interprofessional funds) and leverage its potential among private and public stakeholders. SETS will also support the skills development of companies providing digital solutions and innovative technologies and VET providers  for SEOs. The project will follow a work plan based on seven interconnected work packages: management and coordination (WP1), Skill gap analysis (WP2), Development of trainings (WP3), Piloting and testing (WP4), Certification and recognition (WP5), Assessment, promotion and scale-up of the project impact (WP6), Dissemination and communication (WP7). The rationale for formulating the SETS consortium is based on the creation of a value chain at two levels, national level and European level. The partnership covers 4 countries (BE, IT, FR, SI), but the skill gap analysis will be run at pan-European level as 2 of the beneficiaries are EU-level umbrella organisations or support structures, while the testing and implementing of skills development programmes and training will be carried out in France and SloveniaThe consortium combines: •DIESIS: A EU Level support structure for SEOs  •ALL DIGITAL: a pan-European association working to enhance digital skills •TIRESIA Politecnico di Milano: a technology, innovation and research centre for social impact, in Italy•OPEN IMPACT: an innovative start-up and accredited spin-off of the University of Milano-Bicocca •SOGA: a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An intelligent brokering service for knowledge-component reuse on the world-wide web' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of IBROW3 is to develop an intelligent brokering service that enables third party knowledge-component reuse through the World-Wide Web. Suppliers provide libraries of knowledge components adhering to some standard, and customers can consult these libraries -through intelligent brokers- to configure a knowledge system suited to their needs by selection and adaptation. A customer in this context is a person/company that wants to solve a reasoning problem, such as the configuration of a technical product; a supplier could be a commercial or non-commercial provider of knowledge components that implement reasoning services.On successful completion of the project, the following results can be expected.- An intelligent web-broker that can handle web requests for PSM services. The broker is able to handle both the customer and the supplier side of the request. It will access libraries on the Internet, search for appropriate PSMs, verify their requirements, ask additional information to the customer if needed, adapt the PSMs to the particular domain knowledge and plug them together.- A description language to characterise PSMs, which can be used by the knowledge-component providers -to indicate what kind of problems their software can solve (their competence) and what knowledge they require- and by the broker -to find and select candidate PSMs.- Methodological guidelines for third parties that describe how to provide new libraries with reusable knowledge components (complying with the description language and the interoperability protocol), and how to develop intelligent brokers.The World-Wide Web is changing the nature of software development to a distributive plug & play process. This requires a new way of managing software by so-called intelligent software brokers.The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Expressive Shape: Intuitive Creative and Optimization of 3D Geometry' in the context of a Seventh Framework call.

assistant: **Objectives**

We propose radically new concepts for creating digital and real shapes with the help of computers, considering characteristics of human perception, cognition, and established workflows in art and design. Traditionally, real objects were created and optimized based directly on their visual impression. With the introduction of CAD/CAM, this immediate feedback has been lost, replaced by an engineering pipeline that capitalizes on mathematical representations and accurate machining. We believe to have identified the fundamental problems in this process, and propose research that leads to tools that support creation of shapes by humans and for humans.The research is concerned with data structures and algorithms that support the optimization of virtual and real shapes so that they possess and clearly convey desired features. This will lead to user interfaces for shape design based on features that humans understand and already use for communication. It will also lead to techniques that optimize the geometry of shapes so that the desired features stand out in likely viewing and illumination conditions. We will further extend the optimization to include the illumination, opening up an entirely new way to create the visual world around us.While the research is primarily concerned with geometry, it relies on results in perception, cognitive science, mathematics, and other disciplines, and by means of cross-pollination might lead to fruitful insights across the boundaries of computer science. The resulting tools will help making digital shapes a commodity, with effects on markets, industry, and society similar to what we have experienced for digital music or images.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Locating and Performing Irish Theatre Histories'.

assistant: **Innovation**

LAPITH aims to embed in Trinity College Dublin substantial, new methodological expertise in the use of 3D modelling and virtual worlds in arts and humanities research, by investigating historiographical approaches to and historical understandings of patterns of theatre development in twentieth-century Dublin, and to align this new research strength with cognate areas already in place in Trinity College.Building on the applicant’s extensive experience of managing numerous large-scale digital research projects in UK universities, an innovative, integrated methodological blend of computer modelling, virtual worlds, performance film-making and oral history will be constructed to make critical, historiographical and cultural interventions that will impact on the prevailing narratives of Irish theatre history and digital scholarly publishing, reaching both subject specialists and a wider public audience.In parallel, the project will exploit this historical research as a test-bed for further developing the ""London Charter for the Computer-based Visualization of Cultural Heritage"", a widely adopted and cited international methodological standard, which the applicant initiated, and now develops and drives towards UNESCO-ICOMOS endorsement. Through this activity, the project will leverage into engagement with Trinity College as a research community the applicant’s international network of digital cultural heritage researchers and professionals.The project entails close interaction with several researchers and research groups at Trinity College, and strategic engagement with a local cultural heritage and digital solutions SME with an exemplary track-record of collaboration with both TCD and the applicant. It will lead to major new, collaborative funding applications, and will fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Tundra biogenic volatile emissions in the 21st century' under Horizon 2020.

assistant: **Concept**

Biogenic volatile organic compounds (BVOCs) influence atmospheric oxidation causing climate feedback thought to be especially significant in remote areas with low anthropogenic emissions, such as the Arctic. Still, we do not understand the dynamics and impact of climatic and biotic BVOC emission drivers in arctic and alpine tundra, which are highly temperature-sensitive BVOC sources.TUVOLU will redefine tundra BVOC emission estimates to account for rapid and dramatic climate warming accompanied by effects of vegetation change, permafrost thaw, insect outbreaks and herbivory using multidisciplinary, established and novel methodology.We will quantify the relationships between leaf and canopy temperatures and BVOC emissions to improve BVOC emission model predictions of emission rates in low-statured tundra vegetation, which efficiently heats up. We will experimentally determine the contribution of induced BVOC emissions from insect herbivory in the warming Arctic by field manipulation experiments addressing basal herbivory and insect outbreaks and by stable isotope labelling to identify sources of the induced emission. Complementary laboratory assessment will determine if permafrost thaw leads to significant BVOC emissions from thawing processes and newly available soil processes, or if released BVOCs are largely taken up by soil microbes. We will also use a global network of existing climate warming experiments in alpine tundra to assess how the BVOC emissions from tundra vegetation world-wide respond to climate change.Measurement data will help develop and parameterize BVOC emission models to produce holistic enhanced predictions for global tundra emissions. Finally, modelling will be used to estimate emission impact on tropospheric ozone concentrations and secondary org
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'QCD challenges in precision physics at the LHC' (QCDchallenge) under Horizon Europe.

assistant: **Objectives**

In the next decade, the experiments at CERN's Large Hadron Collider (LHC) will provide us with measurements of astounding precision, by shrinking experimental uncertainties to the level of 1%. These will be crucial to probe the fundamental laws of Nature at high energies. Indeed, small deviations between measurements and predictions of the Standard Model would signal the presence of new physics. To exploit the potential of the LHC, it is imperative that theoretical predictions will match 1% accuracy. In this context, Quantum Chromodynamics (QCD) poses one of the major challanges. Due to the relatively large QCD coupling constant, perturbation theory must be pushed to the frontier of third-order corrections, or Next-to-Next-to-Next-to Leading Order (N3LO). In addition, due to the multi-scale nature of QCD processes, perturbative corrections are enhanced by large logarithms of the scale ratios, which require to resum the perturbative series.This project will provide new methodologies for QCD calculations at high precision and state-of-the-art results for two complementary classes of enhanced contributions. One are the collinear logarithms, which govern the scale dependence of the parton distribution functions (PDFs). Building upon a breakthrough discovery that I achieved in multiloop renormalisation, I will compute the N3LO evolution of the PDFs, which addresses one of the largest sources of theoretical uncertainties at the LHC and enables QCD phenomenology to reach 1% accuracy.Another class of enhancements, known as high-energy logarithms, arises when the centre-of-mass energy of the collision is much larger than the momentum transfer scale. I will tackle the factorisation of the Next-to-Next-to-Leading Logarithms (NNLLs) in multi-leg amplitudes, building on recent progr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Radial Glia as Neurodevelopmental Mediators Of Gut Microbiota Signals'.

assistant: **Objectives**

Brain development is an intricately orchestrated process, that is sensitive to the influence of peripheral processes. One such peripheral factor known to have multiple roles in host physiology, is the gut microbiota: the ecosystem of symbiotic microorganisms that populate our gastrointestinal tract. Disruption of the gut microbiota has been associated with neurodevelopmental and neuropsychiatric disorders. However, the mechanisms through which the gut microbiota could influence brain development, and thus potentially lead to cognitive and behavioural deficits, remain to be elucidated.  RADIOGUT aims to mechanistically understand the interactions between the gut microbiota, and brain neurodevelopment at molecular and cellular levels. To accomplish this, we will employ distinct models of early-life microbiota disruption in mice and assess the impact on neurodevelopment combining explant cultures with microbial metabolites, and an integrated multi-omics analysis. We will identify key microbial metabolites that modulate neurodevelopment, discern their signalling mechanisms and their potential to rescue neurodevelopmental deficits as well as later life aberrant behaviours. RADIOGUT will explore for the first time how the primary neural stem cells in the brain, the radial glia, can act as cellular sensors of microbial signals that modulate neurodevelopment. It will fill a large gap in the understanding of microbiota-gut-brain axis development and its communication code, as well as deliver tangible future translational value.


**Keywords:** radial glia, microbiome, blood-cerebrospinal fluid barrier, microbiota gut-brain axis, gut microbiota