RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Trouble in the air: How European forests keep their cool under atmospheric drought' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The 21st century has witnessed a steady rise in the frequency and intensity of heatwaves, creating unprecedented challenges for ecosystems. Europe, in particular, has experienced its hottest heatwaves in the past two decades, increasingly coupled with elevated vapor pressure deficit (VPD)—the atmospheric demand for water—resulting in a new form of “atmospheric droughts.” These droughts disrupt plant water relations, diminish carbon sink capacity, and trigger large-scale tree mortality.  Our overarching goal is to unravel how European forests respond to rising VPD and temperature, their extremes, and compounding soil drought effects. COOL integrates innovative methodologies, including state-of-the-art laboratory experiments, the first-ever VPD manipulation in a natural forest, a pan-European monitoring network, and advancements in mechanistic modeling. We will (1) systematically assess what drives trees’ thermal and VPD tolerance, an area previously unexplored but crucial for predicting forest resilience; (2) disentangle, for the first time, the impacts of temperature, VPD, and soil moisture in natural settings—an achievement made possible by novel methodological developments; (3) investigate the role of long-term acclimation to temperature and VPD under varying soil moisture scenarios, leveraging unprecedented experimental infrastructure; and (4) quantify the consequences for forest growth, water use, and tree mortality. By combining cutting-edge approaches to collect high-resolution hydraulic and thermal data, COOL overcomes a critical bottleneck in forest research. The project will deliver groundbreaking insights into forest resilience under future climates. These results will advance climate-smart forest management, inform policy frameworks, equip stakeholders with a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New bioreactor for aerobic fermentation processes' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The research aims at development of a new fermentor concept. In 1985 one of our collaborators patented a pumped tubular loop reactor: HIPERLOOP. This reactor proved to be able to overcome the main limiting factor of aerobic industrial fermentors: oxygen transfer due to improper mixing. Especially for viscous media where oxygen transfer is very low, HIPERLOOP is expected to increase the volumetric productivity and thereby reduce energy use and cost price considerably.Disadvantage at that time was the impossibility to recycle cells from the reactor in a cost effective way. Our research aims to integrate the two technologies and will take advantage of new developments in cell-recycle systems to complete the concept. The technology will be used to develop three types of processes: Lysine, Citric acid and Biopolymer fermentation. For these processes a significant cost reduction (20-50%) will be realised.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Effective Business Processes For Smes In The Ict Modern Era', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

EBUSINESSPROCESS will develop a suite of software to improve the business performance of the software and service industries with particular emphasis on the needs of VSE and SMEs. The solution will strengthen business competitiveness and improve openness of software. The solution is comprehensive. It is aim at the life cycle for software development and at the cycle for services industries. An intranet solution will be produced. It will comprise of wireless technology, application software and interactive multi-media. The solution will be piloted at VSEs (<12) and SMEs (< 250). The life cycle solution will provide for effective knowledge management, decision management support, best practice model, workflow, verification & validation and continual improvement. It will also address client retention management, resource and chain management control. Exploitation is a key consideration of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New Carbohydrate Oxidising Enzymes prepared by directed evolution and their application in synthesis of AminoGlycoside derivatives with antibiotic potential and rare sugars.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Carbohydrate-oxidising enzymes (COE) are a group of enzymes which are active on specific carbohydrates and can use molecular oxygen as a mild oxidant. Oxidation is typically directed towards specific positions of the sugar ring. Regioselectivity and substrate specificity relies on the architecture of active site, therefore the direct evolution approach in this project will allow to generate a toolbox of effective and regiospecific catalysts to modify various carbohydrate scaffolds. Our aim is to use this toolbox to generate a library of bioactive compounds: i) aminoglycoside derivatives starting with analogues of Kanamycin as candidates to help in the fight against the global problem of antimicrobial resistance. This process in combination with a further chemical step may lead to a large library of derivatives prepared in short time with only a two-step chemoenzymatic process; ii) rare monosaccharides and oligosaccharides as promising candidates with health benefits. Antimicrobial activities of prepared library of compounds will be measured and statistically evaluated. Furthermore, this project will advance the current knowledge of COE which is of utmost interest for fundamental biology and crucial for industrial biotechnology and chemistry applications. Biocatalysis will be applicable to the synthesis of a wide range of saccharide related compounds, solving one of the big challenges in carbohydrate chemistry, the regioselective differentiation of the OH groups, in a green, sustainable and very efficient way.


**Keywords:** Biocatalysis, carbohydrate oxidases, aminoglycoside antibiotics, rare sugars, regioselective synthesis, enzyme engineering, industrial biotechnology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Concept Development and Experimentation for EU Conflict Prevention and Peace-building' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

CDE4Peace will explore the potential of Concept Development and Experimentation (CDE) for enhancing the EU’s conflict prevention and peace-building policy. CDE is seen as a promising tool for the transformation of complex security systems - especially in NATO context - but its potential for EU policies hasn’t yet been investigated. The project therefore will assess the applicability and compatibility of the CDE methodology and tools with strategic and operational concepts in the area of EU conflict prevention and peace-building (CPPB). Furthermore, the project will introduce and adapt CDE to EU CPPB by defining the requirements for an innovative CDE tool tailored for this specific policy area. Finally, the project will define actionable policy recommendations for implementing the CDE methodology and tools in the complex EU policy-making process. The project will employ an interdisciplinary methodology for applied policy research which links qualitative research methods from Conflict and Peace studies with quantitative CDE tools. This innovative research methodology follows a four-phase operational logic: 1) Concept review and quantification; 2) Technology assessment of CDE tools; 3) Definition of requirements for an innovative CDE tool; and 4) Policy recommendations for integrating the CDE methodology in the EU decision-making. The project will clearly contribute to the European Research Area by linking the academic and policy analysis on EU conflict prevention and peace-building with experimental research and CDE in particular. As a Marie Skłodowska-Curie action, it will also enhance the potential of the experienced researcher by a carefully-designed international and intersectoral mobility.In general, the project’s research and innovation objectives are highly relevan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Baltic Summer School 2000: Current trends in Immunology and Signal Transduction' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Advanced training of young researchers is a most important factor for the future development of biomedical science. Based on regional links, collaboration and expertise in science and education the Medical Faculties of the Universities of Copenhagen, Kiel and Lund have established the Baltic Summer School (BSS) to combine their efforts in training of young researchers. BSS_2000 will concentrate on highly relevant topics of immunology and signal transduction.It will focus on(i) the molecular and cellular basis of the innate and adaptive immune system;(ii) the interdisciplinary processes of signal transduction, including death receptors, intracellular signalling cascades, significance of lipid second messengers;(iii) selected applied aspects as the immune response against transplanted tissue and tumours.These fields have dramatically expanded because of the rapid scientific development and the need to cope with chronic progressive diseases, which are an economic burden to Society. BSS_2000 is thus timely from a scientific, technological and socio-economic point of view. The project is important for understanding basic mechanisms, but at the same time highly relevant for the development of new therapeutic strategies in clinical conditions as transplantation, cancer, autoimmune diseases, and chronic infection. Thus, it addresses a wide scientific community, from researchers in basic sciences to physicians working in clinical research.BSS_2000 will be open for 65 young researchers from all over Europe. State-of -the-art lectures by international experts in the respective fields will illuminate the theoretical background and practical applications. Plenary and round table discussions, seminars, and demonstrations by scientifically profiled biomedical companies will supplement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'REGULATION OF GLUCOSE-STIMULATED SECRETORY VESICLE MOBILISATION IN PANCREATIC BETA-CELLS'.

assistant: **Innovation**

During meals our bodies break food down into glucose which then moves from the bloodstream into cells to be utilised. This process requires insulin production by the pancreatic beta-cells. Impaired function of these cells leads to inadequate insulin output and elevated blood glucose level. The failure of beta-cells is the main reason for the development of diabetes which affects 22.5 million people in the European Region. We are interested in the mechanisms by which beta-cells respond to changes in blood glucose concentration with insulin release.  In beta-cells insulin is carried in vesicles, called large dense core vesicles (LDCVs). The mechanics of the transport and fusion of LDCVs are one of the steps that go wrong in type 2 diabetes. Our recent studies have revealed that LDCVs move along their tracks driven by motor proteins such as conventional kinesin. This project aims to understand how the activity of these proteins is regulated by glucose.  The spatial-temporal relationship between LDCVs and conventional kinesin movements in response to nutrients will be studied using real time imaging. The role of glucose-stimulated protein kinases and phosphatases in controlling LDCV and kinesin movements and their impact on the association of kinesin with vesicles will be investigated.  Novel beta-cell specific kinesin interacting proteins, that link kinesin to LDCVs, will be identified together with the signalling pathway(s) involved in the mobilisation of LDCVs. This multidisciplinary project will reveal fundamental information on the molecular mechanism and regulation of glucose-stimulated LDCV mobilisation.  Stimulation of this process may provide novel strategies for the treatment of type 2 diabetes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced dEsign and testing of a polArimetric X-banD antenna for avionic weather radar' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The project AhEAD - Advanced dEsign and testing of a polArimetric X-band antenna for avionic weather radar, aims at designing and testing a polarimetric avionic radar antenna operating at X band for weather characterization and classification.After the requirements have been defined, the project will identify the best solution of the antenna configuration in terms of technology and architecture by examining the performances of different solutions. The antenna will be designed and a breadboard will be manufactures and tested to evaluate the expected performances.A technological roadmap for full device development will be identified.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fluorescent Optical Concentration of Uncollimated Sunlight' (FOCUS).

assistant: **Innovation**

There is an urgent need to use solar energy to produce electricity, fuels and chemicals.  However, the highly diffuse nature of sunlight in angle, wavelength and space complicate its high-efficiency, low-cost and scalable conversion. FOCUS will develop thin-films that concentrate sunlight in these three aspects, creating collimated, monochromatic, high-intensity beams that can provide advantages for photovoltaics and photocatalysis. The underlying concept is a radically different design for a luminescent solar concentrator (LSC). Conventional LSCs use an emitter-doped plastic or glass sheet as a waveguide, concentrating direct and diffuse sunlight via total internal reflection of fluorescence. The losses associated with reabsorption, emission into the waveguide escape cone and Stokes shift have limited LSC efficiency to 7%. I will eliminate the waveguide completely and replace it with nanophotonic lenses, solving the longstanding problems with LSCs. The key challenges for successful implementation are addressed in three work packages. Nanophotonic design (WP1) will give FOCUS foils that absorb broadband sunlight from all angles, funnel the excitons to lower bandgap nanoscale emitters and concentrate the collimated fluorescence outside of the film. Material learning (WP2) and reciprocity-inspired photosynthesis will use the desired emission pattern to train a material to emit from self-optimized positions, leading to FOCUS foils that learn the desired optical output. Ultrafast 3D nanoprinter (WP3) development will lead to a microscope that synthesizes emitters directly within a solid-state host, tracks their performance (quantum yield, angular emission pattern) in real-time and watches excited carriers relax into directionally emitting states. My track record in nanophot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fully digital Blockchain-based Laboratory Operations Control System for real-time and audit-proof Good Manufacturing Practice conformity' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

B-LOCS aims at monitoring the analyses performed on the laboratory software and at detecting whether the raw data have been altered by anomalies resulting from protocol errors or actions that do not comply with the GMP rules. B-LOCS records in real time the events that occur on the files from the lab software and sends them to a smart contract on a blockchain. In order to properly report the status of the analysis, the business logic of each software (for file creation or invalid action events - e.g. file deletion) is recorded immutably in a Smart-Contract. Any deviation is reported and triggers real time configurable alarms. The strength of this approach lies in the trust provided by the Smart-Contract running on the blockchain: it contains the business logic that decides whether the latest event impacts the validity of a laboratory analysis performed. There is no way to bypass this GMP-relevant business logic; no way to override the B-LOCS and the history of the blockchain.


**Keywords:** end-to-end transparency,Laboratory digitisation,Patient safety,Documentation and Reporting,Good Manufacturing Processes,Immutability,Trust,Audit-proof,GMP Compliance,Data Integrity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Quantum Thermodynamic Framework to Advance Fault-Tolerant Quantum Science'.

assistant: **Innovation**

Quantum information science has reshaped our understanding of the universe by framing the fundamental laws of nature in terms of the evolution of information. This field has provided powerful mathematical tools to address open questions in physics while opening the door to novel technologies without classical counterparts. However, the current prototype devices at the forefront of technological advances are still far from the promised fully programmable universal quantum simulators. These current machines, known as Noisy Intermediate-Scale Quantum (NISQ) devices, are constrained by their susceptibility to errors, limited scalability, and, more importantly, the incomplete understanding of the underlying physics in multi-partite quantum systems.This research proposal aims to tackle a fascinating challenge: developing a theoretical thermodynamic framework to gain insights into error correction and mitigation in complex quantum systems, while addressing open questions from a thermodynamic perspective. Additionally, this project seeks to bridge the gap between fundamental research and practical implementation. In this project, I will develop novel quantum error correction (QEC) approaches that optimize both information retention and energy efficiency, focusing on three key objectives:(1) Quantum Error Correction as a Thermodynamic Process: Reimagining QEC as a thermodynamic process through entropy management and cooling mechanisms, such as algorithmic cooling, to gain insights into fundamental questions and develop QEC codes optimized for resilience and energy efficiency.(2) Thermodynamic Understanding of Fault-Tolerant Thresholds: Integrating thermodynamic principles to understand the limitations of achieving more robust quantum protocols based on available resources.(3) Im