RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tailoring Mixed-Metal Chemistry for Frontier Synthetic and Catalytic Applications' (MIXMETAPPS) targeting Seventh Framework.

assistant: **Abstract**

Designed to meet many of the colossal challenges facing synthetic and organometallic chemists as demanded by current societal, environmental and economic issues, this project will accelerate the development of a  innovative mixed-metal chemistry, which combines two metals with markedly different polarities in the same molecule. Initially polar Mg and non-polar Zn “hybrids” will be developed followed by other metal pairs. These hybrids will exhibit a unique chemistry distinct to those of their parent monometallic compounds. Building on our recent pioneering work in this area (PNAS 2010, JACS 2010) that uses a tried and tested metal-structural-inorganic approach that allows rationale design of tailor-made mixed-metal reagents, this novel and ambitious research programme will deliver new chemo- and regioselective organobimetallic reagents designed as transformational tools for a broad spectrum of fundamentally important chemical reactions (deprotonation, metal-halogen exchange, alkylation, reduction, electrophilic amination, cross-couplings, etc), used every day in academia and industry. Catalytic, using cheap environmentally benign inorganic salts as catalysts, as well as stoichiometric advances will be made. Mixed-metal reagents will also be pioneered in Green Chemistry, by screening their reactivity using green solvents (e.g., 2-methyltetrahydrofuran) and ultimately, the holy grail, using water, which would inspire a synthetic revolution. Bulky ligand supported mixed-metal reagents will be constructed to activate organic heterocyclic molecules towards novel cascade reactions. Incorporating transition metals and lanthanides to this hybrid methodology will expand even more their opportunities in synthesis towards the development of hybrid catalysts for cross-coupling reac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Interactive Systems Involving Multi-point Surfaces, Haptics and true-3D displays' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The grand challenge of this project is to 1) develop integrated multi-point surfaces that include multiple touch points, multiple haptic feedback on fingers (and tangible objects on the surface) and reconfigurable ‘true-3D’ content for a ‘walk-up and use’ scenario; 2) identify interaction design principles and visualization techniques to support users around such surfaces and 3) demonstrate the added value of this multi-point surface by integrating this within the workflow of stem-cell researchers  to demonstrate that better visual and mechanical characterization of biological processes is achievable with our system.The knowledge generated can be applied to a wide range of applications from entertainment and education to medical and life-sciences. For example, with our proposed system students can collaborate around an interactive table to feel plant textures and human organs while visualizing them in 3D while discussing with fellow students to allow for a very rich learning experience.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular genetics of chamber specification in the developing heart: implications for congenital heart disease' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives:%ù To provide refined maps of transcriptional compartments in the developing heart.ù To identify factors and mechanisms responsible for cardiac chamber formation and specification.ù To map transcriptional domains in experimental models of congenital heart disease.Brief description:This project aims at identifying inducing signals and transcription factors implicated in the specification of cardiac chambers during embryonic development. Multiple approaches will be used to dissect the molecular mechanisms responsible for generating patterning and diversity in the developing normal and malformed heart. Cardiosensor" transgenic mice containing promoter/enhancer elements of cardiac genes linked to reporter genes will be used to reveal positional signals present in specific cardiac chambers. "Transcriptional domains", corresponding to cardiac compartments showing regional patterns of transgene expression, will be followed during cardiac morphogenesis. The boundaries between such compartments will be further refined by crossing mice from different transgenic lines, and cisacting sequences mediating regionalised transgene expression will be delimited. These sequences will be further characterized by transfection experiments, both in vitro in cultured cardiomyocytes and in vivo by direct DNA injection in adult rat heart. Differential screening techniques will be used to screen known transcription factors which may be differentially expressed in the heart and to search for novel structural and regulatory genes showing regionalized patterns of expression. Transcriptional domains will be mapped in different experimental models of cardiac malformations by crossing mice expressing chamber-specific transgenes with mutant mice with congenital cardiac malformations, such as i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'CRACKING THE CODE BEHIND MITOTIC FIDELITY: the roles of tubulin post-translational modifications and a chromosome separation checkpoint' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

During the human lifetime 10000 trillion cell divisions take place to ensure tissue homeostasis and several vital functions in the organism. Mitosis is the process that ensures that dividing cells preserve the chromosome number of their progenitors, while deviation from this, a condition known as aneuploidy, represents the most common feature in human cancers. Here we will test two original concepts with strong implications for chromosome segregation fidelity. The first concept is based on the “tubulin code” hypothesis, which predicts that molecular motors “read” tubulin post-translational modifications on spindle microtubules. Our proof-of-concept experiments demonstrate that tubulin detyrosination works as a navigation system that guides chromosomes towards the cell equator. Thus, in addition to regulating the motors required for chromosome motion, the cell might regulate the tracks in which they move on. We will combine proteomic, super-resolution and live-cell microscopy, with in vitro reconstitutions, to perform a comprehensive survey of the tubulin code and the respective implications for motors involved in chromosome motion, mitotic spindle assembly and correction of kinetochore-microtubule attachments. The second concept is centered on the recently uncovered chromosome separation checkpoint mediated by a midzone-associated Aurora B gradient, which delays nuclear envelope reformation in response to incompletely separated chromosomes. We aim to identify Aurora B targets involved in the spatiotemporal regulation of the anaphase-telophase transition. We will establish powerful live-cell microscopy assays and a novel mammalian model system to dissect how this checkpoint allows the detection and correction of lagging/long chromosomes and DNA bridges that would otherwi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PRODUCTION TUBING WITH INTEGRATED HYDRAULIC CONTROL LINES' (INTEGLINE) targeting Fourth Framework.

assistant: **Abstract**

The aim of INTEGLINE project with the corresponding technology objectives are directly upon field operation and safety requirements. When an oil well is put into production the standards of safety stipulate that the well head must be equipped with a subsurface safety valve arranged in the well at a depth of about 30 m under the surface (ground or sea bed). This valve is intented to close off the well in the case of an accident, and in the majority of installations is hydraulically actuated. The presence of an hydraulic line on the outside of a tube which is lowered into a well means that the lines at risk of mechanical damage or even crushing as a result of more less violent contacts between the tube and the casing or even indeed on passing into the blow-out preventer. The resultant hydraulic leak necessitates a costly loss of time especially for offshore wells in order to effect the replacement of the damaged conduit. Still more serious, this leak can come to light much later, then requiring intervention with an apparatus which is especially hired for the propose. Moreover, the hydraulic conduit, constituted, for example, by brine, by sulphate reducing bacteria, by traces of corrosive gas, etc., an environment which can attack the hydraulic conduit in the more and less long term. Another problem is found at the level of the safety closing devices which are configurated to close off the well with the production tubes in the well. These closing devices are equipped with semi-circular jaws which interact in a leakproof way with the outer surface of the tube. The presence of hydraulic conduit on this outer surface can give rise to leaks at the level of the jaws or deterioration of the latter.In summary, the aims or advantages of the INTEGLINE project can be summarised as f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SUMO proteomics in C. elegans: focus on meiosis and the DNA damage response' in the context of a Seventh Framework call.

assistant: **Objectives**

SUMO (small ubiquitin-like modifier) is a small peptide that can be covalently attached to target proteins in an analogous way to ubiquitin. SUMO is involved in transcriptional regulation, sub-cellular partitioning, stress response, and DNA damage response, among other processes. The roles for the SUMO conjugation pathway have been mainly addressed using transformed cell lines and yeast. To address the relevance of the SUMO conjugation pathway in a living organism, I will use the round worm, Caenorhabditis elegans, a multicellular eukaryotic organism simple enough to be studied in great detail. I plan to characterize the SMO-1 (the C. elegans orthologue of SUMO) proteome using high accuracy mass spectrometry (MS). Moreover, dynamic changes in the SMO-1 proteome in response to ionizing radiation as well as tissue-specific SMO-1 sub-proteomes will be assessed taking advantage of the recently developed SILAN (stable isotope labeling with amino acids in nematodes) technique. In parallel, the role of SMO-1 conjugation in the DNA damage response and meiotic recombination will be addressed by genetically altering the conjugation pathway. I will also study the dynamics of specific SMO-1 conjugates after ionizing irradiation, by applying multiple reaction monitoring (MRM)-mass spectrometry. The role of SMO-1 modification of selected target proteins will be addressed by generating transgenic strains carrying a sumoylation deficient allele. Overall, this project combines high accuracy mass spectrometry and the nematode C. elegans to provide insights into the biological consequences of dynamic, tissue-specific SUMO conjugation. Importantly, this project will guarantee a leading role for the European Research Area in this field and the expertise I will obtain with Dr Hay will be vit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DRIVIN' CAR: Developing robust in vivo nanomedicine-based chimeric antigen receptor technology' (2021-2027) under Horizon Europe.

assistant: **Objectives**

DRIVIN’ CAR aims to transform immunotherapy by developing a scalable, cost-effective platform for in vivo generation of chimeric antigen receptor (CAR) immune cells. Using proprietary apolipoprotein nanoparticle (aNP) platform technology, DRIVIN’ CAR pursues robust CAR monocyte/macrophage (CAR M) and CAR T cell therapy. Owing to their biocompatibility and natural tropism for myeloid cells, aNPs are excellently suited for in vivo CAR M therapy. For efficient in vivo T cell targeting, aNPs can be modularly surface-functionalized with apolipoprotein fusion proteins.The Program’s aNP platform technology addresses key limitations of current CAR therapies that prevent widespread implementation. It simultaneously tackles high treatment costs, complex ex vivo manufacturing procedures, and poor performance in solid tumors of conventional CAR cell therapy. The aNP platform also overcomes challenges associated with emerging in vivo approaches, such as limited specificity and safety risks.By combining advanced bioengineering, high throughput manufacturing, library screening approaches and in vivo validation, DRIVIN’CAR brings together world-leading experts to deliver a unique and versatile platform for in vivo CAR therapies with real clinical impact.This Program’s successful completion will advance the aNP platform to TRL 4.  Besides enabling in vivo CAR immune cell therapy for cancer treatment, the aNP platform has significant translational potential and pertinency for applications in non-malignant diseases such as autoimmune disorders and cardiovascular disease.


**Keywords:** Nanoparticles, in vivo CAR cell therapy, CAR T, CAR M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel efficient solid storage for hydrogen' under Sixth Framework.

assistant: **Concept**

The proposed IP would drive forward the research and development of solid storage of hydrogen for vehicle propulsion and associated distribution functions. The proposed work programme will cover porous storage systems (particularly at reduced temperatures) , regenerative hydrogen stores (such as the borohydrides) and solid hydrides having reversible hydrogen storage and improved gravimetric storage performance. Initially, two categories of reversible stores will be investigated - light/complex hydrides, such as imides and intermetallic systems involving magnesium, although further categories may be included later. In all cases, the performance of different possible systems will be compared by a standards laboratory (working in collaboration with the US DoE st andardisation activity). Further, etforts will be made to understand the mechanisms involved by innovative modelling activities. The organisation of the IP will include the development of a Virtual Laboratory concept, the exchange of specialised staff betw een participating laboratories and appropriate training activities. When promising new materials are identified, industrial collaborators will be brought in to upscale the material production, develop appropriate demonstration storage tanks and test out th e prototype stores in practical conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel deSign, producTion and opEration aPproaches for floating WIND turbine farms' (STEP4WIND) targeting Horizon 2020.

assistant: **Abstract**

STEP4WIND aims at increasing the commercial readiness level of floating offshore wind energy through technological innovations across the supply chain. Floating wind turbines (FOWTs) could be a game changer to further decrease the cost of offshore wind energy and unlock new markets. Wind turbines placed on a floating support and moored to the seabed can harness energy in areas with much higher wind speeds, at a reduced installation cost. It also gives the opportunity to countries with deep water to enter the offshore wind industry. The SET-Plan stresses that Europe needs to move fast in deploying FOWTs. It also highlights the urgency to widen the basic knowledge of early-stage researchers (ESRs) towards the design of FOWTs and match it with industrial needs. This European Industrial Doctorate programme will achieve this by delivering 10 doctoral degrees jointly supervised by the public and private sectors. The ESRs will be supervised by 3 universities with a track-record in wind energy research and 5 companies leading the deployment of floating wind farms and heavily involved in policy-making bodies. A mentoring scheme will be tailored to the needs of each ESR, with the involvement of several female senior staff. Scientifically, STEP4WIND will develop floating-specific tools, methods and infrastructures to tackle the technological and economical challenges of FOWTs, from design to deployment, operation and scaling up. The innovations from each ESR will be systematically integrated in a common multi-disciplinary design and optimisation tool to assess their impact on cost, risk and the environment. STEP4WIND will also deliver guidelines for large farm deployments, with a clear roadmap to commercialisation. The results will be disseminated openly in a series of innovative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Enhanced material lifing model for rotating welded structures'.

assistant: **Concept**

Green and sustainable engines require accurate and well documented material data for safe operation of the engines at optimum efficiency. The SAGE project aims at demonstrating open rotor engines and technologies to reduce fuel consumption, weight and increased efficiency of engine components. Structural integrity and safety of engine critical parts have to be considered with regard to design, manufacturing aspects and in-service maintenance and overhaul.The engine operating conditions, thermal and mechanical loads, material properties and other influencing parameters are affecting the Approved Life of the component. Extensive analysis, component & engine tests, and inspections during both component manufacturing and in-service have to be performed for verification. In particular, the regulations required for critical parts to fulfil appropriate damage tolerance criteria has to be considered, and the potential for failure from material, manufacturing and service induced anomalies within the Approved Life of the part. This means that the potential existence of various imperfections, defects and flaws in the component are recognized and are due to material issues, component design and manufacturing. This situation can be handled through the incorporation of fracture resistant design, process control and Non-destructive Testing (NDT).In fabricated components and structures different visual inspection and NDT methods are being used for weld inspection. The quality of the welds will determine the fatigue life of a component. This project will focus on welds made in IN718, both laser welds and TIG welds. Before testing the specimens will be NDT tested (WP2), then high cycle fatigue tested (WP4), creep fatigue tested (WP5), fracture surfaces examined (WP3), statistical analysi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Distributed Global Financial Systems for Society' to be submitted under Horizon 2020.

assistant: **Abstract**

The DOLFINS project addresses the global challenge of making the financial system better serve society by placing scientific evidence and citizens participation at the centre of the policy process in finance. The project strives to give scientific evidence and citizens participation central roles in the policy process concerning finance. DOLFINS will focus on two crucial and interconnected policy areas that will shape the public debate in the coming 5 years: How to achieve financial stability and how to facilitate the long-term investments required by the transition to a more sustainable, more innovative, less unequal and greener EU economy. The expected impact is to achieve crucial advances in reshaping the policy process to overcome the financial and political crisis faced by the EU. We will deliver quantitative tools to evaluate policies aiming to tame systemic risk and to foster sustainable investing. The tools will be based on fundamental research combining network models and algorithmic game theory with broader economic insights. This approach can provide a more satisfactory understanding of credit, risk and sustainable investments in an interconnected world. We will investigate how to engage citizens in the early stage of the policy making process and will develop evidence-based narratives in order to better shape policies in the public interest. To this end, our project will take advantage of semantic web technologies, big data and ICT in general. Given the highly technical nature of key issues in finance, we will explore how ICT and art can facilitate citizens’ engagement through innovative narratives, leading to better coordinated actions of stakeholders.