RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chromatin function in DNA Double Strand breaks repair: Prime, repair and restore DSB Inducible via AsiSI' in the context of a Horizon 2020 call.

assistant: **Objectives**

Among the types of damage, DNA Double Strands Breaks (DSBs) are the most deleterious, as illustrated by the variety of human diseases associated with DSB repair defects. Repair of DSB into the chromatin context raises several questions that we aim to address in this proposal. Firstly, it is likely that the chromatin environment where a break occurs influences the choice of repair pathway. Since the different DSB repair mechanisms can lead to different ""scar"" on the genome, further studies are required to elucidate how chromatin structure regulates the targeting of DSB repair machineries. Secondly, DNA packaging into chromatin hinders detection and repair of DSBs and many chromatin modifications were recently identified as induced around DSBs to facilitate repair. However, a complete picture of the chromatin landscape set up at DSB, and more specifically the set of histone modifications associated with each repair pathway (""repair histone code"") is still awaited. In addition, whether and how damaged chromosomes are reorganized within the nucleus is still unknown. Finally, once repair has been completed, the initial chromatin landscape must be faithfully restored in order to maintain epigenome stability and cell fate.Using an experimental system we recently developed (called DIvA for DSB Inducible via AsiSI), that allows the induction of multiple sequence-specific DSBs widespread across the genome, we propose to investigate these uncovered aspects of the relationship between chromatin and DSB repair. By high-throughput genomic and proteomic technologies, we will try (i) to understand the contribution of chromatin in the DSB repair pathway choice (PRIME), (ii) to describe more thoroughly the chromatin remodeling events and the spatial chromosomes reorganization, that o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'MountBuzz: relating context-dependent bee-flower interactions to macroevolution'.

assistant: **Objectives**

Adaptive evolution of flowers to optimize pollen transfer by animal pollinators is considered a key driver of plant speciation and the success of flowering plants. Plant-pollinator interactions are embedded in complex abiotic (climatic) and biotic (other plants/pollinators) contexts, and the structure and function of interaction networks changes across such contexts. To date, however, we lack a broad-scale perspective on how these contexts affect which flower phenotypes are fit, and how flowers evolve to adapt to these contexts. This knowledge gap limits our understanding of the processes that generate and maintain biodiversity, critically important in light of current global change.In MountBuzz, I aim at developing a novel context-dependent ecological perspective on the processes structuring the evolution of flower diversity by linking the commonly separated fields of community ecology and macroevolutionary modelling. First, to determine which flower phenotypes are fit (high reproductive success) in different a-/biotic environmental contexts, my team and I will analyze plant-pollinator interactions and flower and pollinator trait data along four elevational gradients across the tropics. We will combine empirical field observations with pollination experiments to pinpoint context-dependent changes in phenotype-fitness relationships. Second, synthesizing across these results, we will test whether patterns of flower macroevolution follow predictable, context-dependent trajectories by employing machine-learning based predictive modelling and phylogenetic comparative methods.The results of MountBuzz will deliver a new perspective on the relative importance of pollinator-mediated selection and environment-dependent processes in driving flower evolution and plant diversificat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FEASIBILITY STUDIES FOR THE CREATION OF GLOBAL CARDIOVASCULAR MULTIMEDIA DATABASES (CONSENSUS CONFERENCE)' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

FACT is a feasibility study on the interconnection of European databases for cardiovascular diseases, on which it has represented the European component of a G7 healthcare application sub-project. The many ongoing actions of the latter include the provision of a telematics link among centres of excellence, major operational centres and single users, and telematics support for clinical decision-making. FACT was prominent on the agenda of the 1996 G7-H3 Consensus Conference in Rome, one of the aims of which was to enhance communication between project users such as health authorities, government bodies and industrial partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Spatial Division Multiplexing for Cold-Atom-Based Quantum Memory' (Multiplex).

assistant: **Concept**

Optical quantum memory, a device that enables the storage and retrieval of photonic qubits, is an essential component for a wide range of applications in quantum information science. The host demonstrated state-of-the-art memory based on large ensembles of cold atoms, with a storage-and-retrieval efficiency close to 90% for single photons. With this milestone reached, a timely and crucial effort is to develop multiplexed memories. This, in turn, should lead to higher-capacity network channels, bringing quantum networks one step closer to reality. In this context, the proposed research will uniquely adapt and exploit Space Division Multiplexing, a booming approach in classical telecommunications, to create and harness parallelized quantum links. The fellow, with a strong background in atomic physics and light shaping, will use his expertise to develop the project efficiently while expanding his skill-set to quantum information networks and developing his independence and leadership during the fellowship.


**Keywords:** Quantum memory, Structured light, Atomic ensembles, Space-division multiplexing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Phospholipid hydroperoxide glutathioneperoxidase: promoter, expression, regulation, genetic manipulation and role in the pathogenesis of atherosclerosis'.

assistant: **Objectives**

ObjectivesThe objectives of the application are to understand what factors control phospholipid hydroperoxide glutathione peroxidase (PHGPX EC.1.11.1.12) expression at transcriptional level, what factors are necessary for the overexpression of PHGPX and what is the effect of PHGPX on the development of atherosclerotic lesions in rabbit and mouse arteries. PHGPX will be studied at gene and promoter level, in stably transfected cell culture systems, and in normal and atherosclerotic NZW and WHHL rabbit blood vessels using intraarterial gene transfer.Our application focuses on the understanding of the mechanisms of selenium incorporation into selenoproteins, especially those that control phospholipid hydroperoxide glutathione peroxidase (PHGPX, EC.1.11.1.12) expression and activity. Furthermore, the role of PHGPX in atherogenesis will be studied. Atherosclerosis-related diseases (myocardial infarction, stroke and peripheral vascular disease) cause nearly half of the deaths in the European Union. They have an enormous impact on health and economics. There is much evidence that LDL oxidation and lipid peroxidation play key roles in the pathogenesis of atherosclerosis. For its ability to reduce phospholipid, cholesterol and cholesterol ester hydroperoxides, PHPGX is an essential part of the antioxidative defense against lipid hydroperoxide and radical-mediated injuries. It is anticipated that better understanding of the physiological significance of this enzyme will help us to define new treatment strategies for atherosclerosis. The objectives of the application are to understand what factors control PHGPX expression at transcriptional and translational level, what factors are necessary for the over-expression of PHGPX and what is the effect of PHGPX on the development of ath
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Alternative models and robust decision-making for future forest management' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

European forests are expected to provide a broad range of ecosystem services (ES). This capacity is however threatened by the uncertainties of climate change, the complex dynamics of evolving global markets and the pressures for increased use of bioenergy. Such challenges cannot be effectively addressed with an uncritical regional or national commitment to traditional forest management models (FMMs), as these are unlikely to ensure the sustained long-term provisioning of desired ES, let alone their optimised delivery. ALTERFOR’s goal is thus to facilitate the implementation of FMMs better suited to meeting the challenges of the 21st century by: (1) Identifying and developing FMMs robust in their capacity to deliver ES and overcome projected socio-ecological risks and uncertainties; (2) Assessing the impact of different FMM combinations in terms of resultant ES baskets on the European and landscape level, and (3) Facilitating the implementation of desired FMMs and improving cross-national knowledge transfer regarding their benefits, costs, management, and utilization. The project will involve a consortium of 19 organisations from nine countries chosen due to their possession of the transdisciplinary expertise necessary to achieve these objectives, and for ensuring an encompassing representation of Europe’s socio-economic conditions and prevailing forest management paradigms. Based on carefully designed case studies, the consortium will make sure realistic models of forest owner behaviour are employed; guarantee the involvement of forest stakeholders throughout the project; anchor the desired FMMs to relevant forest actors; and help disseminate project findings to local, national and European stakeholders. The main long-term impact of ALTERFOR is the implementation of FMM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular and functional characterization of sperm-expressed proteins with potential fusogenic roles during double fertilization in Arabidopsis thaliana' in the context of a Seventh Framework call.

assistant: **Objectives**

Sexual reproduction is a fundamental biological process common among eukaryotes. In angiosperms, fertilization although associated with pollination, is actually a fairly late phenomenon in the process of reproduction and involves a double fusion event between two male and two female gametes. In contrast to animal fertilization, the molecular mechanisms underlying this process in flowering plants are poorly understood and the molecular players unknown. With this project we intend to explore recent advances in the field, namely the availability of expression profiles of plant gametes to identify the molecular players which mediate sperm-egg cell/central cell fusion in Arabidopsis thaliana. We used bioinformatics approaches to identify plasma membrane proteins with expression in sperm cells and sharing structural similarities to known fusogenic peptides. The first candidates are two sperm-specific proteins which belong to the conserved family of tetraspanins. Functional analysis of the candidate proteins will be performed in knockout, amiRNA and overexpression transgenic lines. Interacting proteins in sperm cells and in the female partner cells will be identified using yeast-two hybrid system and validated by functional analysis. Candidate proteins will be assayed for specific functions during double fertilization, such as preferential gamete targeting, fusogenic properties, polyspermy block and fertilization barriers using manipulation of gene expression and proteomic approaches coupled to in vivo and in vitro assays. We also intend to develop an in vivo fluorescent based method to detect and track specific sperm-expressed mRNAs, in order to understand the importance of intercellular communication during double fertilization and initiation of embryogenesis. This project i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cutting edge early stage training in genomics, genetics and epigenetics for sustainable animal breeding' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

SABRETRAIN will provide young scientists with high quality MSc and PhD training by utilising the combined resources of international partners with world renowned expertise in livestock genetics. This will prepare researchers with the skills to expand and enhance knowledge of genomics and genetics for sustainable animal breeding, so as to develop livestock production towards more environmentally and welfare friendly, low input systems that deliver safe, high quality foods in line with consumer expectations, and wider EU policy. SABRETRAIN is timely because of the pace of development in genomics, changing demands from agriculture, and the need for new skill sets in animal breeding to remain internationally competitive. SABRETRAIN is relevant because of the scale and importance of EU animal agriculture, it addresses societal and environmental issues, and the strong industrial need for skilled scientists and innovative fundamental research. SABRETRAIN is relevant to the Work Programme objectives as it provides comprehensive training for researchers to develop world-class research and complementary skills and enhance their career prospects by providing access to cutting edge facilities, supervision and stimulating multidicsciplinary environments in leading international research centres with a good track record in training ealry stage researchers. SABRETRAIN will innovate by providing students with improved industrial links, by aligning research to larger European projects and by linking the students to a wider cohort of contemporaries. All participating hosts agree to mututal recognition of the training provided. SABRETRAIN benefits hosts by broadening their training capacity, access to resources and to a flow of skilled Post-doctoral scientists. The improved interaction wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Accelerated Checkpoint Design Integration Test and Evaluation'.

assistant: **Innovation**

The aim of the XP-DITE project is to develop, demonstrate and validate a comprehensive, passenger centred approach to the design and evaluation of integrated security checkpoints (CPs) at airports.  The approach encompasses a variety of different types of requirements, relating to security, airport operations and societal aspects. An ethical framework will be defined which enables designers and operators to proactively introduce ethical factors in the checkpoint. The project team will identify and develop requirements and criteria at integrated system level. A key element of the project is the development of a design tool that allows the design of innovative new CPs and modification of existing CPs to meet changing threats. A major challenge comprises a validated set of protocols and tools for evaluating and monitoring the performance of the CP at the overall system rather than component level. The approach will be demonstrated in two integrated demonstration CPs at two airports. The activities are focussed towards aviation security but may be extended to mass transportation and other applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Catalytic Partial Oxidation of Bio Gas and Reforming of Pyrolysis Oil (Bio Oil) for an Autothermal Synthesis Gas Production and Conversion into Fuels' (BIOGO-FOR-PRODUCTION) under Seventh Framework.

assistant: **Objectives**

BIO-GO-For-Production is a Large Scale Collaborative Research Project that aims to achieve a step change in the application of nanocatalysis to sustainable energy production through an integrated, coherent and holistic approach utilizing novel heterogeneous nanoparticulate catalysts in fuel syntheses. BIO-GO researches and develops advanced nanocatalysts, which are allied with advanced reactor concepts to realise modular, highly efficient, integrated processes for the production of fuels from renewable bio-oils and biogas.  Principal objectives are to develop new designs, preparation routes and methods of coating nanocatalysts on innovative micro-structured reactor designs, enabling compact, integrated catalytic reactor systems that exploit fully the special properties of nanocatalysts to improve process efficiency through intensification. An important aim is to reduce the dependence on precious metals and rare earths. Catalyst development is underpinned by modelling, kinetic and in-situ studies, and is validated by extended laboratory runs of biogas and bio-oil reforming, methanol synthesis and gasoline production to benchmark performance against current commercial catalysts. The 4-year project culminates in two verification steps: (a) a 6 month continuous pilot scale catalyst production run to demonstrate scaled up manufacturing potential for fast industrialisation (b) the integration at miniplant scale of the complete integrated process to gasoline production starting from bio-oil and bio-gas feedstocks. A cost evaluation will be carried out on the catalyst production while LCA will be undertaken to analyse environmental impacts across the whole chain. BIO-GO brings together a world class multi-disciplinary team from 15 organisations to carry out the ambitious projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrostatic Discharge Protection for Emerging CMOS Technologies and RF Applications' in the context of a Sixth Framework call.

assistant: **Objectives**

Electrostatic Discharge (ESD) is known to be one of the main causes for failures in ULSI technologies. These failures are caused by the discharge of electrostatic charge present either on an external body, like humans or machines, or on the device itself. In order to cope with this problem, ESD protection circuits have to be provided at all input, output and power supply pins, to ensure that the discharge currents are safely conducted towards the ground.With the ever continuing scaling of CMOS technologies , the problem of ESD becomes more and more difficult to cope with. This makes the scaled down technologies more vulnerable to ESD discharges with each new technology generation. Moreover, new materials and technology modules are continuously introduced in future technologies: high k dielectrics and metal gates to replace the conventional SiO2/polySi gate stacks, copper interconnects and low k dielectrics to replace the conventional Al/oxide based interconnect schemes, and new types of devices such as FinFet s are under study to cope with the scaling problems of conventional MOSFET and apos;s. The impact of these new modules and materials on the ESD robustness of the devices is unknown and needs to be investigated.The ESD protection of RF CMOS circuits also po ses severe problems. The reason for this is that the conventional ESD protection elements cannot be used anymore due to the too high parasitics of the protection elements. As a result new devices and/or design approaches to provide ESD protection for RF-CM OS applications are urgently necessary.In this project these important reliability issues for future technologies will be studied. The impact of advanced CMOS process modules, novel SOI-based devices and advanced junctions on the ESD performance of more or less