RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coordinated immunity' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Illness caused by bacterial infections is a major burden on the health care system and leads to significant economic loss through sick leave. The steady emergence of antibiotic resistant pathogen strains emphasises the necessity of maximising the defensive potential of natural immunity. In recent years there have been tremendous advances in understanding the ways in which the adaptive immune system deals with pathogens and there have been equally rapid advances in understanding the ways in which the so-called innate immune system holds infections in check. It is now clear that the two systems, far from being independent, are in fact tightly intermeshed so that a host pathogen interaction always involves components from both systems. Indeed it is at this interface between innate and adaptive immunity that the central decisions are taken which determine whether the host's attempts to fend off bacterial attack will succeed. Despite our increased understanding of the coordinated nature of the host response, attempts to develop new therapeutic strategies based on these insights have so far been disappointing. The cause of these failures can in part be traced to the fact that innate and adaptive immunity have till now been largely treated as quite different subjects of investigation. As a consequence no major conferences are currently staged in Europe that are directed to integrating our concepts of these two aspects of defence strategy. The objective of the proposed meetings is to provide a forum within which internationally recognised experts from both sides of the problem will discuss the mechanisms operating at the interface between innate and adaptive immunity. A better understanding of these mechanisms and their coordination will be essential in order that ways can be d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a genetic fingerprint data bank for ornamental crops' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Plant breeders need to protect their cultivars and ensure the novelty of new varieties. Traditional verification methods can be problematic. New Pcr Technology can produce genetic fingerprints rapidly and cost effectively allowing the development of genetic fingerprint data banks for ornamental crops. Research is needed to determine the most appropriate Pcr Technology for ornamental crops, especially roses which would be a good model for other crops. The means of compiling the rose fingerprint information into a PAN European data bank (E.U.R.O. Bank) and extending this to other ornamental crops must be investigated. The proposed finger print bank would be of great assistance to European SME's reducing the lead time to market for new cultivars and significantly reducing the cost involved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Engineering lipid nanoparticles to target and escape the endosome, deliver their cargo and perform better as breast cancer therapies' under Horizon Europe.

assistant: **Concept**

There is a strong need for personalised genetic medicines for the treatment of advanced breast cancer. LNP-mRNA nanomedicines have already been proven as safe and cost effective in the SARS-CoV-2 vaccines. However, cancer treatments often require (i) repeat dosing (ii) controlled immune response (iii) adaptability to combat drug resistance. There are several LNP-RNA clinical cancer trials ongoing, many of which have reported challenges with toxicity, performance and specificity (off target effects). For an LNP-RNA cancer therapeutic to function, they need to localise in the correct organ, enter the cancer cells and escape the cellular (endosomal) processing pathway to release their RNA cargo. In current LNP-RNA formulations only a small fraction (<10 %) of LNPs successfully escape the endosome. However, these ‘null’ LNPs can still contribute to toxicity which places huge restrictions on their clinical application and performance. The aim of this proposal is to provide mechanistic insight into the endosomal escape of LNPs and use nanoscale engineering to target the endosome and improve LNP endosomal escape. This is particularly relevant in breast cancer as the majority of LNP systems are optimised for liver applications and designed to undergo fusion under ‘healthy’ endosomal conditions. In breast cancer, the composition (lipid, protein) and environment (pH) of the endosome differ significantly between healthy and cancer cells. Objectives:- Use omics approaches to quantify key differences in the endosome in healthy and breast cancer sub type cells and develop breast cancer sub type endosome models- Design LNPs with enhanced fusion to endosomes using (i) lipid composition (ii) protein – protein / lipid interactions (iii) pH mediated fusion- Validate novel LNPs with increa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Numerical Algorithms for Automatic Optimization of Preform Design i n Forging.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Foreseen ResultsForging processes are non-linear and path-dependent and one of the most difficult tasks in optimizing them is the efficient evaluation of sensitivities, i.e. the derivatives of the objective function with respect to design parameters. In this project the direct differentiation and adjoint methods will be applied as a replacement for the commonly used but inefficient numerical approximations.Practical assessmentA number of typical optimization problems related to metal forming technology will be formulated and solved to demonstrate the applicability of the approach. A manufacturer of flexible tooling systems is employed in this project to provide practical verification of our results which will help the consortium to promote the use of quantitative optimization techniques and flexible tooling systems in metal forming industry.The main goal of the proposed project is to develop a computational tool for automatic optimization of multistage forging processes. The tool will automatically design the preform required to achieve the desired geometry and material state whilst maintaining a good service life for the tooling system.Attention will be focused on two main problems. First, how to formulate an optimization problem which describes the intentions of a process designer in mathematical terms and secondly, how to solve the optimization problem in a computationally efficient way.Formulation of the optimization problemThe formulations of the optimization problems will be generalized such that they will represent as closely as possible practical demands in the metal forming industry such as good die filling, low material and tool damage, desired microstructural changes and texture evolution, minimum surface wear and fatigue, etc. Although many of these phenomen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Innovative training schemes for retrofitting to nZEB-levels' (Fit-to-nZEB), addressing dissemination and exploitation.

assistant: **Impact**

Reaching of the 2020 and 2030 energy and climate objectives represents a major challenge to the construction sector, which needs to be ready to deliver high energy performing renovations and, in particular, nearly zero-energy buildings. This goal requires a major effort to increase the number of qualified construction specialists at all levels, which is directly related to the accessibility and quality of the training and educational programmes and the inclusion of training on intelligent energy efficiency and RES solutions in building renovation. Responding to these needs, the project is designed to:(i)Elaborate a set of technological competences and learning outcomes on deep energy renovation;(ii)Develop new large scale training schemes and programmes on deep energy renovation at all levels of the vocational education and training (VET) system;(iii)Review the national educational plans and initiate the necessary changes;(iv)Establish capacity for professional training of trainers and train a sufficient number of trainers;(v)Support and monitor pilot courses on the new programmes on deep energy renovation at all levels.The leading objective of the Fit-to-nZEB project proposal is to deliver all necessary requisites for the introduction of educational content on deep energy renovation of buildings in the curricula at all levels of the educational and training system in Southeastern Europe. This will be done both through incorporation of new educational content in existing curricula and through the development of new specialized programs. This process will be guided by the understanding of the complex nature of building retrofit, combining various building disciplines and allowing integrated design and cross-craft understanding with special focus on practical exercises an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Neural Stem Cell Coordination: a Developmental, Evolutionary and Circuit perspective'.

assistant: **Concept**

The adult mammalian brain exhibits a remarkable capacity of adaptation, which has long been thought to result from synaptic remodeling of neurons born during development. Importantly, the discovery that new neurons can be generated in the adult by neural stem cells (NSCs) revolutionized our understanding of brain plasticity. In the adult mouse brain, NSCs reside in two specialized niches: the dentate gyrus (DG), and the ventricular-subventricular zone (V-SVZ) lining the lateral ventricles. Although anatomically and functionally different, these two neurogenic regions share several cell types, including the glial NSCs and their lineage, and are sensitive to similar environmental stimuli. This raises the exciting possibility that NSCs within and between niches could coordinate their behavior under specific contexts. I recently showed that in the V-SVZ, regionally-distinct NSC pools can selectively and transiently respond to specific physiological states. However, such spatial and functional stem cell diversity in the DG remains to be investigated.Here, we hypothesize that the two brain niches form a single plasticity-generator system, comprising multiple stem cell subpopulations, some of which may be inter-dependent. We will first investigate whether some NSC pools across both niches share unexpected molecular features and developmental trajectories. To determine whether and how this V-SVZ/DG system evolved to sustain a plasticity-oriented, regionally-restricted, and transient process in mammals, we will perform comparative transcriptomics with a contrasting model of adult neurogenesis in Zebrafish, which is regeneration-oriented, widespread and continuous. Finally, we will test whether the recruitment of specific adult NSCs in the mammalian brain is orchestrated by neuro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rescate de Experiencias Locales en El Salvador y Nicaragua Para el Proceso de Reforma del Sector Salud en el Periodo de la Posguerra (1990-1995)' under Fourth Framework.

assistant: **Concept**

The general objective of this research project is to analyse the stage of development reached by the health systems in El Salvador and Nicaragua in the post-war period (1990-1995), focusing on the efforts of civil society.Expected OutcomeThis research project is expected to develop guidelines to improve the impact of local initiatives in the health sector. An exchange of successful experiences will be organised within civil society and between civil society and the public sector. At the health policy level, elements for the incorporation of local initiatives in the national health policy will be identified.* An inventory of these local health initiatives will be made and systematised.* These initiatives will be placed in an overall analysis of the specificity of health sector development in these two countries.* The possibilities of a multiplication of the best experiences will be examined on the basis of a detailed evaluation of these experiences.This evaluation of local experiences in health sector development by different actors of civil society will focus on their effectiveness, their sustainability, the degree of participation by the population, and their capacity to enhance the autonomy and equity in health services delivery. Special emphasis will be put on the relationship between the public service and the non-profit private sector, their complementarity and conflicts during this complex period of post-war reorientation and structural adjustment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Rational development of nanocrystalline drugs for skin administration'.

assistant: **Objectives**

Alternative drug delivery is one of the most promising solutions for an increasing number of geriatric and cancer patients heavily challenged by the oral route treatment. Crystals4Skin project targets skin as a pathway for local/systemic therapeutics, bringing ground-breaking approach at the cutting edge of biotechnologies. So far, only particle-size nanomaterials have been explored and used for the skin application. Extreme potential of the crystal form and surface diversity has not been considered as the source of a product innovation for healthier society yet. Crystals4Skin aims to fill the gap in current state of knowledge by the innovative research of nanocrystals-skin interaction through the integration of structure-to-property-to-function principles bridging chemical matter and biology. With cocrystals selected as the models allowing the study of different composition, bulk and surface characteristics, the research will employ the highest knowledge from the fields of crystal structure analysis, simulations, synthesis, physical-chemical characterisation, permeation, and toxicity studies. Targeting Beating Cancer Plan, one of the EU´s flagship initiatives, together with the United Nation´s Good Health and Well-Being sustainable development goal, Crystals4Skin brings together experts in crystal engineering, pharmaceutical technology, and nanomaterials for biomedical applications to answer the burning question: Is it only the size that makes the nanocrystals an extremely promising material of the future or are there other structural attributes driving their performance within the skin? Crystals4Skin aims to find the answer and meet the current discussions between regulators, academics and industrial parties on the control and use of safe and efficient nanomedicines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Assembling the puzzle of the operating auditory hair bundle' under Seventh Framework.

assistant: **Concept**

The hair bundles of the sensory cells play a central role in the processing of sounds by the cochlea. Various performances of auditory perception depend upon what biophysical and physiological environment the operating hair bundle can provide to its mechanoelectrical transduction (MET) channels. The project aims at building a more integrated view of the way the hair bundle works. Reaching this goal, requires to understand the interdependence of its functional building blocks and their dynamic interplay.To this purpose, the objectives of the work are :1. To assemble components of the basal MET machineryThe work aims ata)  identifying the molecular players of the basal MET machinery, most of which are still unknownb)  deciphering their functional interactions,c)  developing a simple and efficient tool to validate candidate components of the MET machinery.2. To elucidate the coupling between MET and stereocilia F-actin polymerisationThe work aims ata)   characterising this coupling, both in development and in steady-state condition,b)   deciphering the role of tip-link tension and Ca+2 influx through the MET channel,c)   developing a coarse-grained mathematical model of this coupling, experimentally testable.3. To understand the interplay between MET, waveform distortions, and maskingThe work aims ata)   deciphering biochemical characteristics of the top connectors,b)  explaining why large waveform distortions vanish in the absence of top connectors,c)  determining how the operating outer hair cell (OHC) hair bundle contributes to the masking        effect in auditory perception.The hair bundle is a highly vulnerable structure, actually the main target structure of noise-induced hearing loss and hereditary deafness forms. As such, advances in the understanding of the mecha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Collaborative Research into Exascale Systemware, Tools and Applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

For the past thirty years, the need for ever greater supercomputer performance has driven the development of many computing technologies which have subsequently been exploited in the mass market. Delivering an exaflop (or 10^18 calculations per second) by the end of this decade is the challenge that the supercomputing community worldwide has set itself. The Collaborative Research into Exascale Systemware, Tools and Applications project (CRESTA) brings together four of Europe's leading supercomputing centres, with one of the world's major equipment vendors, two of Europe's leading programming tools providers and six application and problem owners to explore how the exaflop challenge can be met. CRESTA focuses on the use of six applications with exascale potential and uses them as co-design vehicles to develop: the development environment, algorithms and libraries, user tools, and the underpinning and cross-cutting technologies required to support the execution of applications at the exascale. The applications represented in CRESTA have been chosen as a representative sample from across the supercomputing domain including: biomolecular systems, fusion energy, the virtual physiological human, numerical weather prediction and engineering.<br/>No one organisation, be they a hardware or software vendor or service provider can deliver the necessary range of technological innovations required to enable computing at the exascale. This is recognised through the on-going work of the International Exascale Software Project and, in Europe, the European Exascale Software Initiative. CRESTA will actively engage with European and International collaborative activities to ensure that Europe plays its full role worldwide. Over its 39 month duration the project will deliver key, exploitab