RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Role of Tumour Suppressor Gene Products of Common Fragile Sites in Human Diseases' (TSGPs-of-CFSs), addressing dissemination and exploitation.

assistant: **Impact**

Common fragile sites (CFSs) are large chromosomal regions identified by conventional cytogenetics as sequences prone to breakage in cells subjected to replication stress. The interest in CFSs stems from their key role in DNA damage, resulting in chromosomal rearrangements. The instability of CFSs was correlated with genome instability in precancerous lesions and during tumour progression. Two opposing views dominate the discussion regarding the role of CFSs. One school of thought suggested that genomic instability during cancer progression causes collateral damage to genes residing within CFSs, such as WWOX and FHIT. These genes are proposed to be unselected ‘‘passenger’’ mutations. The counter argument is that deletions and other genomic alterations in CFSs occur early in cancer development. Cancer cells with deletions in genes that span CFSs are then selectively expanded due to loss of tumour suppressor functions such as protection of genome stability, coordination of cell cycle or apoptosis. Recent observations from my lab clearly suggest that gene products from CFSs play driver roles in cancer transformation. Moreover, we have evidence for the involvement of DNA damage and Wwox in pancreatic β-cells in the context of diabetes. Here, I propose to investigate the role of tumour suppressor gene products (TSGPs) of CFSs in human diseases. Three approaches will be taken to tackle this question. First, molecular functions of TSGPs of CFSs will be determined using state-of-the-art genetic tools in vitro. Second, novel transgenic mouse tools will be used to study CFSs and their associated TSGs in preneoplastic lesions and tumours in vivo, with confirmatory studies in human material. Third, we will examine the potential involvement of CFSs and their TSGPs in type-2 diabetes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Novel applications of ultra high Q optical micro-cavities'.

assistant: **Objectives**

Optical microcavities can store in small volumes for extended amounts of time and finding applications in a number of fundamental and applied studies, which range from nonlinear optics, quantum information to biological sensing and telecommunications. Recently, rapid progress has been made in increasing the temporal confinement of photons in microcavities (as given by the quality factor, Q). These advances in Q-factor have allowed us for the first time to observe the regime of strong coupling of an atom cavity system, as well as allowing the integration of nonlinear optical oscillators, such as Raman lasers, optical parametric oscillators and optical switches on a silicon chip.  The current research proposal will build on these advances and explore hereto unstudied and interdisciplinary application areas of ultra-high-Q micro-cavities, such as the exploration of radiation pressure induced phenomena, as well as their use in molecular recognition.  The host laboratory is the Max Planck Institute for Quantum Optics (MPQ) in Garching, specifically the Division of Laser Spectroscopy of T.W. Haensch. The applicant is a German Scientist, who has completed his PhD and Postdoc at the California Institute of Technology (Caltech) in Pasadena, USA and who has recently been selected to establish a Max Planck Junior Research Group.  The MPQ has arranged all necessary practical arrangements for a successful integration of the researcher and his team.  The present proposal will enlarge his research team and increase the leverage of the existing infrastructure provided by the Max Planck Society, allowing the applicant and his team to carry out highly innovative research in a stimulating and exceptional scientific environment.  The project will also contribute to the successful and lasti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Protein function regulation through inserts for response to biological, chemical and physical signals' (PROFI).

assistant: **Innovation**

We live in an era of profound excitement for synthetic biology, which is providing insights into the underlying mechanisms of living systems and powerful tools to modify biological and biomimetic systems using innovative design principles. Regulation of protein function based on the recognition of other molecules or environmental conditions is fundamental to all living systems. My vision and the strategic objectives of the project are to develop a modular platform that imparts proteins with the ability to sense diverse signals, thus enabling the regulation of their function and the introduction of novel properties into biological systems. This project aims to explore unique opportunities for regulating protein function through insertions, leveraging modular building blocks with well-known and tunable properties. By combining these building blocks in innovative ways, proteins and biological systems will be engineered to respond to biological, chemical, and physical signals. The specific objectives of the project encompass: 1) design protein responsiveness to pH and RNA molecules, generating RNA sensors and regulating protein function based on cell type- or state-specific RNA molecules; 2) enable proteins to sense the concentration of other proteins, creating concentration-dependent regulatory circuits with a demonstration of biomedical application; 3) construct de novo mechano-responsive proteins, to prepare genetically encoded mechanosensors tolerant to high forces and mechanoresponsive designs of CAR for cancer immunotherapy and 4), design new protein regulators with favorable in vivo properties and regulators of natural proteins. Through several compelling examples in mammalian cells, this project aims to demonstrate the transformative potential of endowing proteins w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Robust Causal Discovery' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

RObust Causal DISCOveryDue to technological advances, the available amount of data has increased tremendously over the last decade. The fields of data science, statistics, computer science and econometrics have followed this growth as they provide indispensable tools for translating data into insights and knowledge. Where data science was traditionally concerned with learning associations in data, it has recently become clear that causal relations often provide a deeper understanding and a stronger tool in many practical applications. This has led to the flourishing of causal inference with some of the most prestigious scientific awards going to pioneers in the field over the last decade. “Can we learn causal mechanisms from observational data?” is one of the compelling questions that is occupying scientists all over the world. Where it was originally answered by skepticism, it has become clear that we are not completely powerless and there are indeed ways to infer causal structure from observational data under the right conditions. However, all of the current methods assume that the observed data perfectly follows the underlying causal structure. Unfortunately, real world data is often contaminated by anomalies and measurement errors, violating this assumption and thus weakening the reliability of methods for causal discovery. This proposal aims to fill this gap by developing methods for causal discovery that remain efficient and reliable under data contamination. In particular, it (i) builds a theoretical framework for robust causal discovery, (ii) develops methods for causal discovery that are provably robust and correctly identify the causal structure and (iii) investigates the effect of contamination on real-world discovery tasks. As a result, in addition to advanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Environmentally compatible antifouling coatings for the protection of ships, water systems, fish cages and other immersed structures against aquatic growth'.

assistant: **Concept**

The work is separated in biocides and binders for AF Paints:BiocidesWithin task 1 a choice was made of four different classes of biocide compounds for further development in the project.The composition of compounds in each class has been adapted interactively with the results of biological tests. These tests consisted of laboratory barnacle bioassays and microbiological assays (task 3).In this way 204 compounds have been synthesised by various partners within task 2 and subsequently tested in task 3.The most promising ones, in total 16 compounds, have been considered for further paint testing.These tests involved:- Incorporation in model paints and static exposure of panels with these paints in the North Sea and in the Mediterranean (task 5);- testing some of this paints on anti barnacle properties by laboratory assays (also task 5);- Performing a number of environmental tests within task 6. These tests have been specially developed or adapted to seawater conditions.Finally, combining the results of all these tests with the physical and economical properties three different (groups of) compounds have been considered for further development in coatings and patenting. In particular, compound CAULB13 has been upscaled and applied at larger scale in model and company coatings for testing in situ: at various rafts and ships (activities within task 5).From the positive results from tests on ships and at rafts at different locations around the world, in particular if formulated in a company related coating, it is concluded that compound CAULB13 so far appears to be the most promising one:- satisfactory antifouling properties up to 26 months;- relatively low toxic effects on non-target organisms;- appropriate water solubility;- simple synthesis and cheap, readily available star
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Support of dissemination and exploitation of results obtained in research projects realized with the participation of the SME sector' (USEANDDIFFUSE), addressing dissemination and exploitation.

assistant: **Impact**

The Strategic Objective of the USEandDIFFUSE project is to enhance dissemination and exploitation of research results and facilitate the exchange of good practices. The project will focus mostly on RTD projects involving SMEs implemented under the Framework Programmes, and within key industrial sectors (ICT, Energy, Health, Environment and Agro-Food).  Based on past experiences and reviews of best practices at EU level, this project will concentrate on the development and implementation of strategies aimed at reinforcing the exploitation of RTD results, as well as clustering of projects on common topics to improve interaction, joint dissemination and exploitation activities. Support of dissemination and practical exploitation of RTD results will be realized via the organization of study visits, exchange of good practices and drawing up of joint plans and strategies for the comprehensive promotion of project results.  A central project component will be the creation of a practical, freely available Best Practice Manual entitled “Use & Diffuse: European Excellence”, which will deliver a close look at the most interesting cases, methods and solutions for the road-mapping of an effective strategy for the dissemination and exploitation of RTD results, as well as methodologies for realistically establishing their true market potential. Suggestions on innovative approaches, to be used in various branches of the economy will be delivered. The Guide will be widely disseminated at EU-27 level to key actors and stakeholders, in particular European Technology Platforms, clusters and SME associations.  The project will count on the invaluable knowledge and experiences gathered by qualified project partners from Poland, UK, Germany, Spain, Czech Republic and Cyprus, who are all actin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EGFR signalling talks to mitochondria through contact sites' (EGFRtoMITO).

assistant: **Concept**

The integration of distinct internalization routes is crucial to determine the fate of plasma membrane (PM) receptors and the output of their signalling pathways. Contact sites between cellular organelles adds a further layer of regulation by creating microdomains that favour different signalling and metabolic pathways. These regulatory mechanisms are relevant to the epidermal growth factor receptor (EGFR). We found that EGFR internalization through non-clathrin endocytosis (NCE) leads primarily to receptor degradation and signal extinction, while clathrin-mediated endocytosis (CME) is mainly involved in EGFR recycling and sustaining signalling. Notably, internalization via NCE involves the formation of contact sites between the PM, the endoplasmic reticulum (ER) and the mitochondria, where EGF-dependent localized Ca2+ signalling occurs.The founding hypothesis of this proposal is that the PM-ER-mitochondrial interface could represent a functional unit where direct cross-communication between EGFR signalling and mitochondria takes place. To investigate this hypothesis, we will use a three-tiered strategy aimed at elucidating:1. the EGFR-dependent signalling that leads to NCE-ER-mitochondrial contact site formation and to local Ca2+ release, and the role of these contacts in EGFR endocytosis, signalling and fate; 2. the crosstalk between EGFR signalling and mitochondrial function at the PM-ER-mitochondrial interface by analysing the impact of EGFR-NCE on mitochondrial physiology and metabolism;3. the relevance of NCE-ER-mitochondrial crosstalk to EGF-dependent cell physiological responses, e.g., migration, proliferation and differentiation, by exploiting isogenic cell derivatives from embryonic/pluripotent stem cells or ex vivo organoid cultures.The verification of this h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Tailoring topological properties in Weyl semimetal thin films'.

assistant: **Innovation**

Recently discovered topological Dirac and Weyl semimetals are provoking an incredible interest not only because they represent a point of contact between high-energy and solid state physics, but also due to the technological perspectives they offer in the fields of electronics, spintronics, spin-caloritronics, quantum computing and energy harvesting. Although several exceptional properties, caused by the non-trivial topology, have been observed on macroscopic single crystals, many concrete applications pass through the integration of candidate materials into nano/micro-structured devices.  To this aim, the establishment of methods to fabricate high-quality thin films and the investigation of the evolution of their topological transport properties with scaling the sample dimensions is a crucial step, but the current state of art is still strongly lacking. In this project, I want to fabricate thin films of selected topological semimetals with different magnetic ground states (non-magnetic, ferromagnetic, non-collinear antiferromagnetic) using the pulsed-laser deposition technique and set a protocol to optimize the growing conditions. The aim is to explore the evolution of their topological electric and thermoelectric transport properties, including anomalous Hall and Nernst effects, chiral anomalies and giant magnetoresistance, as a function of different tunable parameters (thin film thickness, sample lateral size, temperature, magnetic field, strain). This will be achieved through a sophisticated method of sample patterning with a multiple-approach, which combines optical lithography and focused-ion-beam techniques. In this way, I will be able to obtain highly conditioned micro/nano-structures with an optimal control over the geometrical factors. This study will be of cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Roadmap for the Chemical Industry in Europe towards a Bioeconomy' (RoadToBio).

assistant: **Concept**

RoadToBio will deliver a roadmap that will specify the benefits for the chemical industry along the path towards a bioeconomy to meet the societal needs in 2030. The roadmap will contain the following two main components:(1) An analysis of the most promising opportunities (sweet spots) for the chemical industry to increase its bio-based portfolio, as well as the technological and commercial barriers and the hurdles in regulations and acceptance by society, governing bodies and the industry itself.(2) A strategy, action plan and engagement guide to overcome the existing and anticipated barriers and hurdles as mentioned above. Furthermore it will bring together different parts of chemical industry, society, and governing bodies, to start a dialogue and to create a platform where this action plan can unfold its full potential, in order to help meet the very ambitious targets of the BIC for 2030.The approach is based on three pillars, which are(a) analysis of status quo and potentials,(b) forward looking activities,(c) continuous feedback loops and interactions with stakeholders. The results will be wrapped up and phrased as a roadmap and an engagement guide describing the benefits and a way forward for the European Chemical Industry towards a more bio-based future. In order to derive a holistic roadmap that can lead the way, the analytical part of the project will consider feedstocks, technologies and markets as well as regulatory issues, societal needs, consumer questions and communication.The consortium partners bring in complementary expertise in relevant fields of the bioeconomy and chemical industry, covering in depth all aspects that need to be included in the roadmap. All partners have been or are still actively involved in successfully completed and ongoing FP7, H2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Boost BLUE economy trough market uptake an innovative seaweed bioextract for IODINE fortification'.

assistant: **Objectives**

The main objective of the project is to produce in a cost effective way new high quality seaweed iodine products and become market leaders in this niche market. The expected revenue in 5 years will be 3,3 million euro and we expect to increase our staff in 20 people. Iodine deficiency is one of the three most common nutritional deficiencies and is spread all over the world and 40% of the world’s population remains at risk for iodine deficiency.Seaweed is the most reliable source of natural iodine. However, seaweed creation is dominated by larger players, mainly from Asia. Our strategy is not to compete with them, but  target for a niche market that is yet incipient - high quality seaweed creation for the development of natural protein products, rich in essential aminoacids and natural iodine.The seaweeds created in the fish aquaculture farms are autochthonous from our region and have a high iodine content and a high degree of stability. They are better than the products in the market (iodine composition 30% higher and vitamin C 300% higher than usually commercialized seaweed products) and with our already tested innovative biorefinary process we will be able to put the product in the market at a competitive price (10% to 30% lower).A nutritional analysis has been done. The biorefinary process has been developed for small production. This has now to be better defined in order to process a higher amount of productUBQ is a high-tech company, and are specialized in the production of natural extracts obtained from marine seaweed. For the 1st stage project, the objectives are to study the: 1.1. Refinement of the nutritional and biochemistry analysis of the selected seaweed1.2. Requirements for upscale the innovative biorefinary process for a higher production 2.1.  Refinement