RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'An Odyssey without borders: soil microbiota as drivers of plant species coexistence along successional gradients'.

assistant: **Objectives**

Our planet is in a biodiversity crisis. To counteract biodiversity loss, the EU’s Biodiversity Strategy for 2030 aims to protect vulnerable ecosystems, reverse ecosystem degradation, and restore biodiversity on agricultural land. However, successful restoration and conservation of plant diversity is hindered by limited understanding of the principles that govern the ability of plant species to coexist and drive plant diversity. My proposed research aims to address the major challenge of restoration and conservation of plant diversity by examining how soil microorganisms contribute to plant species coexistence. My project will draw together fundamental coexistence theory and state-of-the-art knowledge from plant ecology, microbial ecology and soil ecology to reconcile how pathogens and mutualists drive plant coexistence. To develop successful strategies of conservation and restoration of plant diversity it is critical to define a single predictive theory on the role of soil microbes in plant coexistence. I propose to reconcile pathogen- and mutualist-driven coexistence hypotheses into a single framework by addressing two objectives:Along a successional vegetation gradient in which belowground interactions switch from pathogen to mutualist dominated, I will 1) identify which pathogenic and mutualistic microbes plants accumulate with increasing intra-specific density, and 2) determine how these soil microbes influence host plant coexistence. Results will uncover the role of pathogens and mutualists in driving coexistence and whether these different groups of players are mutually exclusive or act simultaneously. This will lay the foundation for urgent tailor-made applied research on the key processes that need conservation and restoration of grassland systems, and uncover t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Molecular Mechanisms of Endometriosis'.

assistant: **Objectives**

Endometriosis (the presence of endometrial-like tissue or ‘lesions’ outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent grow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Three-Component Fermi Gas Lattice Experiment'.

assistant: **Innovation**

Understanding the many-body physics of strongly correlated systems has always been a major challenge for theoretical and experimental physics. The recent advances in the field of ultracold quantum gases have opened a completely new way to study such strongly correlated systems. It is now feasible to use ultracold gases as quantum simulators for such diverse systems such as the Hubbard model or the BCS-BEC crossover. The objective of this project is to study a three-component Fermi gas in an optical lattice, a system with rich many-body physics. With our experiments we aim to contribute to the understanding of exotic phases which are discussed in the context of QCD and condensed matter physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Prostate MR Medical Imaging Biomarker Platform' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Our company, QUIBIM S.L., is a high-tech SME specialized in machine learning and image processing technologies applied to the creation of imaging biomarkers from medical images. The core of our business is QUIBIM Precision®: https://precision.quibim.com/: a world-class medical imaging quantitative analysis platform used by dozens of hospitals and medical research institutions. As of writing, the platform is able to analyse lung and brain images.After analysing the market, the technology, our own capabilities and the rate of incidence of diseases we have decided to put the focus for the period 2020-2021 on updating the Platform with a novel module addressed to the analysis of prostate MR images. This new module will take the name of qp-Prostate® The module will include several analysis plugins, which focuses on the analysis modules of Diffusion - ADC and Perfusion - Pharmacokinetics, specifically for prostate cases. Finally, before start marketing our solution, as a medical device, we will also need the corresponding Regulatory Certifications, scientific and regulatory reviews to evaluate the safety and effectiveness of the new medical software device.New horizons for QUIBIM S.L.: Since the QUIBIM was born, we have put tremendous efforts in the development of our own R&D and resulting technologies in automatic data analysis, machine learning and algorithms to allow a better performance and accuracy in medical images explorations, identifying quickly patterns and details not obvious to the human eye. The company wishes to market qp-Prostate®, an image processing software package to be used by trained professionals, including radiologists specialized in prostate imaging, urologists, oncologists and MR technicians. qp-Prostate® will be the first imaging biomarker analysis p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Distraction and task-performance optimization: an integrative neurocognitive approach'.

assistant: **Objectives**

Giving adequate responses to infrequent, unpredictable events occurring in the environment is crucial in many tasks in everyday life (e.g. driving a car, etc.). Such events draw our attention away from the task at hand, or make the use of infrequently used response alternatives necessary, and thereby often lead to a temporary performance loss: responses are slower and more mistakes are made. Most studies focus on the question how the chain of processing events related to distraction triggered by infrequent, unpredictable stimuli unfolds. However, to understand how these distraction-related processes counteract or change task-related processing, one has to consider how performance is optimized in the given task. The goal of the present project is to investigate these processes in the auditory domain, using an integrative approach, which takes both distraction and task-performance optimization into account.By using novel experimental paradigms, behavioral measurements, and high-density EEG recordings, we are going to investigate how task-related attention builds on and influences sensory processing using the concept of attentional templates. We are going to investigate how task-related selective attention sets can be maintained despite the presence of occasional distracting stimuli, that is, what mechanisms are used to shield ourselves and to recover from distraction. Furthermore, we will investigate how stimulus-response translation-related processes contribute to streamlining task-performance. The project will expand our knowledge on auditory perception, attention- and executive functions-related topics. Beyond their basic scientific significance, the results will contribute to a better understanding of attention-related disorders and age-related changes in task-related
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Sync- high level synthesis of a remote i/o for a numerical control system'.

assistant: **Objectives**

- Introduce a new and up-to-date design technology which, to a previous analysis, did not appear to be economical for a small enterprise. - Compare the cost of design of electronic modules using traditional methods and a high level automated system.- Improve the quality of electronic design with the use of automatic simulation and timing analysis.- Increase the competitive position of the company by the reduction of time-to-market of new products and more modular structures in the products.- Analyse the time required to prepare all necessary tools (hardware and software) to make the board testable on automatic testing machines in production.- Increase the productivity of designers allowing them to concentrate on system functionality described as an algorithm rather than in terms of circuits and gates.The object of this Application Experiment is a full and practical test for assessing the actual advantages to be obtained by a small enterprise in using a modern (and very expensive) automated synthesis tool (SYNOPSYS) for the design of electronic systems based on full-programmable devices. The experiment is based on the complete design of a family of modular units for actuating a variety of I/O devices interconnected with a fibre optic link.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NANOmaterials for the REStoration of works of ART' to be submitted under Horizon 2020.

assistant: **Abstract**

Currently there is a lack of methodologies for the conservation of modern and contemporary artworks, many of which will not be accessible in very short time due to extremely fast degradation processes. The challenge of NANORESTART (NANOmaterials for the REStoration of works of ART) will be to address this issue within a new framework with respect to the state of the art of conservation science. NANORESTART is devoted to the development of nanomaterials to ensure long term protection and security of modern/contemporary cultural heritage, taking into account environmental and human risks, feasibility and materials costs. The market for conservation of this heritage is estimated at some €5 billion per year, and could increase by a significant factor in the next years due to the wider use of nanomaterials. The new tools and materials developed will represent a breakthrough in cultural heritage and conservation science and will focus on: (i) tools for controlled cleaning, such as highly-retentive gels for the confinement of enzymes and nanostructured fluids based on green surfactants; (ii) the strengthening and protection of surfaces by using nanocontainers, nanoparticles and supramolecular systems/assemblies; (iii) nanostructured substrates and sensors for enhanced molecules detection; (iv) evaluation of the environmental impact and the development of security measures for long lasting conservation of cultural heritage. Within the project the industrial scalability of the developed materials will be demonstrated.NANORESTART gathers centres of excellence in the field of synthesis and characterization of nanomaterials, world leading chemical Industries and SMEs operating in R&D, and International and European centres for conservation, education and museums. Such centres will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cardiac fibrosis versus regeneration: lessons learned from the zebrafish' (CAREFISH), addressing dissemination and exploitation.

assistant: **Impact**

Myocardial infarction (MI) leading to ischemic heart disease is the most common cause of death worldwide. In mammals, MI results in the in the replacement of the damaged myocardium with a scar. However, other animals, such as teleost fish have a remarkable capacity to regenerate damaged tissue replacing it with newly formed tissue. Recently, a zebrafish model of MI has been established. Cryoinjury (CI) of 25% of the ventricle leads to massive cell death and the deposition of fibrotic tissue. While in mammals cardiac fibrosis is irreversible, in the zebrafish the scar regresses and the injured area is replaced by new cardiomyocytes.  Although the regenerative capacity of the zebrafish heart was described a decade ago, little is known about its molecular mechanisms.The aim of this project is to analyse the fate of myofibroblast during cardiac regeneration in the zebrafish. Only few apoptotic myofibroblasts are detected after CI leaving several questions unanswered as to what happens to these cells.Another important aspect is to understand the molecular mechanisms behind cardiac regeneration in a MI-model in zebrafish. We will test if cardiac regeneration is accomplished by the re-expression of developmentally active genes. We will study the role of the transcription factor tbx1 (involved in cardiac development in zebrafish as well as in humans), which has been identified in a recent screen performed in the host group. We will also analyse the function of molecules secreted from the epicardium. This mesothelial layer has been recently shown to play a pivotal role during cardiac repair and, given its accessibility, poses an attractive target for therapeutic intervention.In sum, this project will characterize how in zebrafish mechanisms driving cardiomyocyte proliferation an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effect of upscaling of input data on the output of predictive models in relation to catchment water quality' under Fourth Framework.

assistant: **Concept**

We propose to quantify the effects of 'upscaling', i.e. changes in the scale of temporal and spatial inputs (e.g. soils, landuse, farming practice, climate), on the output of well-characterised process-based models as used to predict water quality in catchments. Model predictions obtained at different scales of resolution of the inputs will be compared with measured data for named chemical species in catchment waters in European cool marine, cold temperate and temperate Mediterranean climates. The test substances will be nitrate-nitrogen and pesticides. The research addresses the following key questions: 1. how can model(s) be run with more limited data (spatial and/or temporal) than was allowed for in the design of the model(s); 2. what effect(s) do the limitations of available data have on model output(s); 3. what can be reasonably predicted - annual mean concentration, peak events maximum concentration etc., and under what conditions; 4. are the problems/consequences the same at all geographic/temporal scales, and with simple versus more complex models; 5. to which factors are the models most sensitive in this context; 6. can these problems be dealt with in a structured manner; 7. can the answers to such questions be formalised so that users know the degree of confidence which can be attached to model output under a range of input conditions. To keep the research within practical limits, we will model using: WAVE : for process-based modelling of N species; MACRO : for process-based modelling including preferential flow, of pesticide species; SWATCATCH : a less complex model to predict nitrate and pesticide concentrations, respectively, and flow volumes at catchment  outlets; ANSWERS 2000 : for distributed modelling. We also propose to: - show how the large amounts of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MAGNETIC HYPERTHERMIA FOR METASTASIZED TUMOR TREATMENT AND REMOTE MANIPULATION OF MICRODEVICES' (GIULIa).

assistant: **Concept**

In magnetic hyperthermia (MHT), magnetic nanoparticles (MNPs) convert magneto-energy into heat under a time-varying magnetic field. MHT with MNPs is used in catalysis to promote reactions in solution and in cancer therapy, to ‘burn’ primary tumors in clinic, e.g. Glioblastoma, upon deposition of nanoparticles at the tumor site. The power of MHT, being an externally triggered approach to produce heat, goes beyond these actual uses. In GIULIa project I will apply MHT in tasks not yet explored to target the unmet needs of treatment of metastasized tumors and address MHT-mediated locomotion. MHT treatment of cancer metastases is now not doable because of scarce MNP dose accumulation at the spreading tumor sites. In GIULIa, MNPs designed for MHT, will be loaded in/on natural killer (NK) immune cells, which, intravenously injected, will deliver as Trojan horses the right dose of magnetic materials needed for MHT to the metastases. I will aim at raising the capability of NK and CAR-NK immune cells to infiltrate and recognize the tumor. This will merge synergic toxic effects of NK cells immunotherapy with MHT-heat damage of MNPs.Next, magnetic microdevices and their remote locomotion based on MHT-heat gradient, represent a new technological solution for delivery purposes with no tissue-depth attenuation for their actuation. Under MHT, I will explore the localization of heat spots on metallic magnetic-based heterostructures as a means to generate bubbles in a liquid and drag an ad hoc designed magnetic-microdevices to which the heterostructures are anchored. For the scale-up synthesis of metallic-magnetic heterostructures needed for the microdevices, I will merge an in-flow approach to an MHT-route synthesis. The heat at the MNP surface will be used as an in situ energy source t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Skill Performance Estimation from cARdiac Signals' (SPEARS).

assistant: **Innovation**

In any learning situation, be it math education, language learning or sport training, different learners have different abilities, motivations and capacities at any given time. Thus, an optimal learning can only be achieved with personalized training solutions, dynamically adapted to each learner’s cognitive and/or physical states. The scientific literature showed that such states could be estimated from Cardiac Signals (CS). In ERC PoC SPEARS, we thus propose to redefine consumer training apps, by enabling them to propose personalized and adaptive training plans according to an estimation of their users’ cognitive and/or physical states from their CS measured with consumer grade sensors, e.g., smartwatches. The outcome of ERC project BrainConquest should enable us to tackle this challenge. Indeed, in BrainConquest we explored such a personalized training approach for users of Brain-Computer Interfaces (BCI). In doing so, we developed Machine Learning (ML) and Signal Processing (SP) algorithms to estimate users’ mental states and predict their upcoming performances from their brain and physiological signals, including CS. In SPEARS, we thus aim at adapting, improving and assessing BrainConquest ML & SP algorithms, initially designed for BCI performance prediction from research grade brain and CS sensors in the lab, to predict cognitive and physical performance from consumer grade CS sensors in the wild. Such algorithms could be used for adaptive training apps in education, cognitive training for healthy aging or sport training. We will then explore a commercial application of this technology for sport training in particular, in collaboration with the startup Flit Sport, which sells an app for providing personalized training exercises for endurance sport athletes, based