RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New-generation database capacity planning optimization' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The global data center market will double its size over the next 5 years, reaching a total of $304 billion. As a result of this, efficient database capacity planning will be essential to keep operational costs under control. However, current capacity planning relies heavily on manual analysis, leaving to systematic capacity over-dimensioning and unnecessary license and hardware costs.  Over the last 5 years, we have developed GOVERNOR: a complex but intuitive capacity planning software. GOVERNOR offers a standalone solution for efficient server consolidation and optimization. Our patent-pending solution reduces the total number of servers by matching the optimal database instances for each server and by maximizing the resource efficiency. This results in database lifecycle savings of up to 50%, at equal or better performance. For large companies with significant database infrastructure, this represents savings of over €1 million per year. GOVERNOR already supports Microsoft SQL Server, the database brand with the largest market penetration. For the Phase 2, we will finish development of GOVERNOR with 4 strategic additional features to support faster and broader scaling of the business:  Cloud environment planning support (covering Microsoft Azure and Amazon Web Services), planning support for Oracle, a GOVERNOR SaaS version and integration to market leading third-party tools.  Commercially, we will continue our expansion across Europe and USA, in collaboration with our network of partners in the Software Asset Management and Managed Services Providers industry. In this context, we expect to expand the implementation of GOVERNOR and reach a total of over 200 large businesses by 2024. This will result in €200 million in cumulated savings for key enterprises in the EU and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PHAGENET: PHAge GEnetic NETworking in the microbiome' (PHAGENET) targeting Horizon 2020.

assistant: **Abstract**

Horizontal gene transfer (HGT) is one of the primary forces driving rapid adaptation and long term evolution of complex microbial communities such as the human microbiome. The same process is involved in the dissemination of virulence and antimicrobial resistance genes and emergence of “superbugs”. The precise mechanisms and role of HGT in the structure and function of the microbiome remain largely unexplored.Bacteriophages are ubiquitous and highly abundant members of the human microbiome, accounting for ~5% of total microbial DNA. Many of them, such as crAssphage, are highly prevalent and have evolved complex relationships with their microbial hosts. At the same time their role in microbiome composition and function is unclear. Recently we observed the accumulation of considerable amounts of bacterial genomic DNA in the phage-encapsulated fraction of human faeces (up to 50% in some instances). Analysis of this chromosomal fraction reveals that it does not appear to be due to contamination, but rather represents phage-mediated mobilisation and transfer (transduction) of DNA from specific bacterial taxa and specific genomic regions.PHAGENET argues that phage-mediated transduction plays a significant role in the genetic plasticity of the human microbiome, and that the phageome provides individual microbes with access to a wider pangenome and enables dissemination of genes both within and across individual human microbiomes. I propose to thoroughly test this hypothesis at molecular, cellular and organismal levels.  This will involve an array of approaches, including long-read high-throughput sequencing, faecal chemostat models, random transposon insertion libraries in gut bacteria and animal models.By addressing an important gap in our understanding of the microbiome, PHA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A SYstem for reaL-time obserVation of Aeroallergens' in the context of a Horizon Europe call.

assistant: **Objectives**

Primary biological aerosols (bioaerosols: mainly pollen and fungal spores, but also bacteria and viruses) released into the air by plants, fungi, and other biota, are strongly impacted by climate change. Simultaneously, they also directly affect the climate through interactions with clouds and precipitation. Many bioaerosols, especially pollen and some fungal spores, have allergenic effect on humans. Such aeroallergens affect over 80 million Europeans, reducing their quality of life and costing well over €50 billion/year. Information on bioaerosols is also vital for agriculture and forestry, where timely data about plant development, abundance of pathogens and parasites, as well as invasive species, are necessary for precision-agriculture and knowledge-based technologies. The demand for timely, free, and objective information is currently not met. The overall goal of SYLVA is:To achieve a radical improvement and fill gaps in temporal resolution, timeliness, coverage, and availability of information about aeroallergens and other bioaerosols. SYLVA technological innovations will be accompanied with new infrastructure, distribution and exploitation pathways, and links with stakeholders to ensure technology uptake and sustainability beyond the lifetime of the project.To achieve this goal, the project will:- Develop cutting-edge bioaerosol monitoring technologies- Create bioaerosol monitoring ICT infrastructure and software following open-source principles and connect it to European environmental observing systems- Validate the operational maturity and added-value of bioaerosol monitoring technology through Demonstration Pilots in three European regions - Maximise impact by demonstrating SYLVA innovations to key stakeholders related to climate, health, agriculture, silvicult
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Distributed Access Management for Language Resources' under Sixth Framework.

assistant: **Concept**

DAM-LR proposes to develop and deploy an infrastructure for the European research community that is interested in an easy management of and access to linguistic resources of all kinds such as large (multimedia) corpora, lexicons, grammar descriptions and others. It will not only foster the local developments that take place at this moment in various linguistic data centres by deploying prototypical archive solutions but also integrate these local archives virtually such that users of linguistic resource s just see one large collection, users have just one identity to access the stored material, ingest mechanisms allow users to integrate new data into this domain of linguistic resources, managers get efficient tools to manage resources in the distributed domain and managers get efficient mechanisms to deal with the access management aspects. Therefore, the proposed DAM-LR concept will offer completely new opportunities for the producers of data, for the managers and for the users. In doing so DAM-LR wil l be a very important contribution to establish a Semantic Web of language resources, since only an integrated domain based on interoperable concepts such as unified access mechanisms will allow agents to smoothly find their way in a complex domain of he terogeneous data types. DAM-LR will be based on 4 pillars that have been discussed intensively at various international meetings. (1) The metadata concept for language resources has been developed during the last 4 years and can be seen as being stabili zed and solid. (2) The introduction of unique resource identifiers will be important for operating in distributed collections and DAM-LR can use well-proven technology here. (3) A unified user and group management system will give persons one identity fo r accessing all re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Resurrecting, re-evolving and re-inventing Rubisco: From the evolutionary past of Earth’s No. 1 CO2-fixing enzyme to its synthetic future'.

assistant: **Concept**

Can we re-construct the engine of natural CO2-fixation? Rubisco catalyzes the key reaction in photosynthesis: the capture and conversion of atmospheric CO2 into biomass. However, despite billions of years of evolution the enzyme is (still) constrained by a trade-off between CO2-fixation activity and CO2-specificity, which limits photosynthetic carbon capture, and thus directly agricultural yield. In pro2neo-RUBISCO, we will overcome this fundamental limitation of photosynthetic CO2-fixation with a completely fresh approach. We will use an evolutionary-synthetic biology strategy to study the evolutionary history of Rubisco, derive a molecular understanding for the enzyme’s mechanism, and develop highly efficient, new-to-nature solutions that we will validate in a real-world context: the living chloroplast. We will use ancestral reconstruction to replay crucial steps in the evolutionary history of the enzyme. We will resurrect the very first scaffolds that just learned to fix CO2 (“proto-Rubiscos”), and study Rubisco ancestors that started to loosely interact with an accessory small subunit. We will re-evolve these ancestral enzymes and provide them with artificial small subunits to open up new evolutionary paths leading to improved variants. These (r)evolutionary studies will be complemented by synthetic biology efforts: We will liberate Rubisco from its entropic constraints by separating the complex multi-step reaction onto different proteins that work in tandem, and go even one step further by re-inventing the enzyme’s scaffold, finding a new home for the Rubisco reaction and create a truly ”neo-Rubisco”.Compared to many efforts in the field, pro2neo-RUBISCO does not screen for existing Rubiscos with improved kinetics or improving existing Rubiscos. In pro2neo-RUBISCO,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Personalised nutrition of low-birth-weight infants' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Each year 500,000 preterm babies are born in Europe out of 15-million worldwide. They often have poor health, with a severe lifetime impact on their quality of life and that of their families. Pre-term birth is a leading cause of lifelong disabilities with high societal economic costs. Inadequate nutrition is the major reason for preterm infants’ ill health. To grow as they would in utero, preterm infants need more nutrition than is provided by their mother’s milk, so the milk needs to be fortified to avoid undernourishment. However, the fortification typically done in Neonatal Intensive Care Units (NICUs) does not take into account the individual differences in the human milk’s composition and the infant’s nutritional needs, which vary with age and weight.To address this issue, Tellspec has developed Preemie, the first rapid, portable, affordable, and easy-to-use milk testing system calibrated with human milk, that automatically calculates the fortification needed, to reduce the workload and human errors. Preemie also uses blockchain technology to trace the origin and confirm the authenticity of the donor’s milk. An inexpensive portable and rapid analyser such as Preemie would disrupt the existing market by allowing NICUs and milk banks to scan all donor milk and automatically suggest fortification to be done based on each infant's individual needs, resulting in optimal health.In this project Tellspec will commercialise Preemie, by tailoring the software to the market and validate it in collaboration with a European hospital and a milk bank, by obtaining the medical certification needed to go to market, and by implementing advertising, sales promotions and marketing activities.The funds raised will enable Tellspec to enlarge its customer base, expand the current team o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Disease therapeutic targets, multidisciplinary parallel validation, accelerated drug discovery' to be submitted under Sixth Framework.

assistant: **Abstract**

Altered gene expression or function in disease indicates disturbed cellular processes and potential new molecular targets for therapeutic intervention. The drug development pipeline however, is plagued by high target attrition rates and extended timelines. Further, advances in genomics have not yet delivered on the promise of a healthcare revolution, even in the context of a completed human genome sequence. Inadequate capabilities to validate prospective targets and leads for functional and especially medical relevance, is a plausible explanation for this failure. In addition, R & D pipelines do not efficiently combine powerful technology platforms. When multiple technologies are combined, it is often with insufficient accompanying expertise so that potential for improvement in drug target development timelines is not met. The PONT consortium will optimize and link together state-of-the-art technology platforms with associated expertise for co-development of drug target candidates by 3 SMEs and 1 larger company. Highly disease deregulated genes identified in human tissues will be interrogated. Parallel informatic analysis will select target subsets with properties consistent with those expected for effective and safe therapeutics. In an innovative parallel drug development approach that also includes 2 academic partners, selected targets will be examined for protein expression profiles with human tissue microarrays, protein structures determined at atomic resolution, functions evaluated with in vitro and in vivo models, and small molecules binding specifically to targets identified with a label-free binding assay. Leads will be optimized with structural analysis of targets complexed with specific binding molecules. Potential aptamer and antibody therapeutics are also bu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design and development of smart coatings for Aerospace applications' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Advanced gas turbine engines necessitate the innovation of newer materials with enhanced properties for obtaining ever-greater efficiency. The newer materials facilitate to use the turbine engines at higher operating temperatures, as the efficiency is proportional to it. Increased temperatures lead to high temperature corrosion (HTC) problems like oxidation, type I and II hot corrosion. HTC is highly detrimental and catastrophic failures are imminent if appropriate coatings are not chosen.This demand can be satisfied only by using smart coatings, which can provide total protection to the construction materials by forming appropriate protective oxide scales depending on the temperatures experienced during service conditions. The project aims at designing and developing such smart coatings by using multiple surface engineering techniques in conjunction with optimised coatings compositions in an appropriate / well ordered manner to effectively combat oxidation, type I and II hot corrosion by creating a more stable oxide scale at a wide temperature range for gas turbine engines.These coatings are planned to prepare by using several surface engineering techniques like electrochemical, PVD, EB-PVD, sputtering, HVOF, chromizing, pack cementation etc, with varying coating compositions, thicknesses at different coating conditions followed by suitable treatments thereby micro structures and optimise them. Characterization of coated specimens (both singular and multiple coatings) by various characterisation technique s like XRD, OP, SEM, EDX, AFM, STM, SIMS and XPS before and after high temperature corrosion studies. This development helps not only in achieving ever-greater efficiency of advanced gas turbine engines but also avoids failures during service.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Advanced NAno-Structured TApeS for electrotechnical high power Insulating Applications'.

assistant: **Concept**

The objective is to develop radically innovative electrical insulating tapes and process to improve the energy conversion efficiency of electrotechnical systems. It mainly addresses the electric power generation issue. Today, the energy conversion efficiency of generators is restricted by (i) thermal as well as (ii) electrical strength limitations due to the electrical insulator tapes themselves. The concepts of these multifunctional tapes are far behind the electrical insulating state of the art. The project aims to develop a new process chain leading to a drastic improvement of insulating tape structure homogeneity. The today’s limitations of tape come from its heterogeneous multilayer structure bringing together very different materials like glass fibre fabric, mica flakes and polymers. Enabling this homogenisation requires higher performance materials, which will be obtained by adjunct of inorganic nanofillers according to two proposed development routes: nanodielectrics polymer or inorganic polymers (sol-gel). This will lead to a more robust process chain with a better productivity (+50%) and an insulating tape with enhanced performances like a higher field strength (+40%), a better thermal conduction (+60%). At the end, a much thinner tape (-30%) enabling the design of more compact generators is expected. This project can strongly impact the energy production field. For instance at the European scale, a +0.2% gain in generator conversion efficiency could save the equivalent of one nuclear power plant of 1000 MW (1.5 billions €), or nearly 10 fossil fuel power plants and related reduction in CO2 emission. It will also affect other very large markets like the industrial motor field using similar insulation tapes. The consortium of ANASTASIA project is equally compos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neural arithmetic of motion vision' (MOVIS), addressing dissemination and exploitation.

assistant: **Impact**

Signal processing by neurons involves arithmetic operations, many of which are nonlinear. These nonlinearities are thought to account for much of the brain’s computational power, yet, little is known about the molecular mechanics that underlie even simple operations like multiplication and division in individual neurons. I will address this problem in the visual system of Drosophila, where the detection of motion represents a canonical example of nonlinear information processing: To perceive visual motion, the signals of adjacent photoreceptors are differentially delayed to coincide at the dendrites of the bushy T-cells, T4 and T5, where multiplication and/or division of these inputs are thought to give rise to direction selectivity. The proposed work will address the following questions: Are the dendritic transformations multiplicative, divisive, or both? Which synaptic inputs constitute the numerator and which the denominator? What receptors and ion channels account for the dendritic nonlinearities and how do they influence the visual perception of motion? The fruit fly enables me to bridge molecular biophysics and optomotor behaviour by granting genetic, electrical, optical, and molecular access to virtually all relevant neurons in a circuit of well-documented synaptic connectivity and transcriptional activity. I will use whole-cell patch clamp recordings in vivo, patch-seq, optogenetics, optomotor behaviour, RNA interference, and computational modelling to identify the biophysical basis of multiplicative and divisive operations in the dendrites of bushy T-cells. The answers will likely hold information that extends beyond the fly’s sense of sight and might uncover previously unknown ways of signal processing by single neurons at the molecular scale.


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