RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Startup Driven Innovation in European Media' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

STADIEM’s ambition is to boost the opportunities and foster the success of European media startups by the creation and deployment of cross border, innovation to market startup growth, development and piloting program between startups, innovation Hubs and other actors. As such STADIEM aims to solve the three key pain points in European media sector: cross border scalability, startup to corporate to market tech transfer, and availability of innovative media services in a Digital Single Market framework. STADIEM intends to break barriers in Europe, fostering stronger visibility and opportunities for startups active in the media industry. The main approach is to create a powerful network of media sandboxes and accelerators that foster the development and scale-up of future media solutions, with a focus on the integration of emerging technologies such as 5G, Cloud, IoT, VR, AR and beyond, smart objects, wearables, data analytics, AI, ...Individual objectives of the project include: Setting up a cross-border community of ecosystems that brings together four innovation hubs focused on media acceleration and achieve seamless collaboration between the hubs and their ecosystems. Develop a cross-border European market-driven media-tech framework and tools focusing on innovation product to market approach including piloting of innovative services with corporate stakeholdersOpen Innovation matchmaking, including launching two open calls for startups to join the 4-stage programme.Create synergies with relevant activities in Europe and worldwide, with the objective to foster awareness, and to offer improved services to startups and scaleups within the network. Create a sustainable ecosystem for startups in media and creative industries. The consortium consists of 4 media innovation hu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Novel and sustainable biotechnological approaches for astaxanthin and ketocarotenoids production'.

assistant: **Objectives**

Microalgae are photosynthetic unicellular microorganisms which can be cultivated at industrial level and adopted as sustainable platforms to produce high value biobased products. Astaxanthin and omega-3 fatty acids are examples of high value metabolites which can be produced by microalgae and that are relevant for both human and animal nutrition. Astaxanthin is widely used in animal feed for its pigmentation properties, but it’s also used in nutraceutics, being among the strongest antioxidants found in nature. Despite the high potential of microalgae, nowadays astaxanthin is mainly derived from chemical synthesis, due to the high costs for natural astaxanthin production and extraction, with selling price in the market reaching several thousands of €/kg. However, synthetic astaxanthin has a far less antioxidant power compared to natural one and its production processes present several sustainability issues. The ASTEASIER project starts from the results of ERC PoC project Asteasy, where novel biotechnological solutions to efficiently produce natural astaxanthin were developed, reducing the production costs compared to the state-of-the-art processes. Moreover, the ASTEASIER solution allows an easy extraction of astaxanthin in a wide range of bland solvents, and the simultaneous production of both astaxanthin and omega-3, required for fish feed formulation, were developed. Here these innovations will be validated in demonstrator units and tested for aquaculture feed formulation. ASTEASIER proposal is thus focused on the development and validation of these novel methods to produce and extract astaxanthin from microalgae and aims, in line with the EIC Transition work Pogramme, to take the technologies to TRL6 and  to spin-off a company who will become leader in engineering mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Expansion microscopy in zebrafish embryo to study primary cilia function during cardiovascular development and diseases' (ZEBREXPANSION).

assistant: **Concept**

This project aims at revealing the function of primary cilia during cardiovascular development and cardiovascular diseases, with a specific focus on cardiac valves, through an imaging approach based on expansion light microscopy. Cilia are evolutionary conserved organelles, involved in fundamental processes such as motility, signalling and mechano-sensing, associated with a group of developmental diseases termed ciliopathies. Cardiovascular defects are common in patients diagnosed with ciliopathies and genetic studies have identified mutations in genes coding for ciliary proteins in patient suffering from congenital heart diseases, suggesting an important role for this organelle in cardiogenesis. In particular, it has been shown that DZIP1, a cilia related protein involved in ciliogenesis, is mutated in patients.  However, little is known about molecular mechanisms underlying DZIP1 abnormal function at developmental stages of valvulopathies. Using an innovative imaging-based approach in human ciliated cells and in zebrafish, we will investigate if cilia assembly, maintenance and disassembly are correlated with essential regulatory functions of DZIP1 during cardiogenesis, more precisely in endocardial cells (EdCs) during valvulogenesis. We will test if the protein DZIP1/Iguana function is not restricted to ciliogenesis in differentiated cells, but displays dynamic functions at centrioles and in the cytoplasm, that are important for tissue-remodelling. My multidisciplinary approach will allow me to tackle this question from the molecular and structural to the cellular and tissue-scale.


**Keywords:** Zebrafish, cilia, expansion microscopy, light-sheet, live-microscopy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Tackling micronutrient malnutrition and hidden hunger to improve health in the EU'.

assistant: **Objectives**

Micronutrient (MN) deficiency is a form of malnutrition that occurs due to low intake and/or absorption of minerals and vitamins, with adverse consequences for human development and health. Children, adolescents, women of reproductive age (including pregnancy) and older adults (representing ~70% of European society) as well as immigrant/ethnic minority groups and those affected by social inequality or poverty, are at risk of MN deficiencies. While addressing this public health problem is a priority, it is not possible until data on the prevalence of MN deficiencies across the EU population and the causes for these deficiencies is available to predict and identify those most at risk. Without this information, discussions on how to meet dietary requirements for the priority MNs of public health concern, and improve their status, take place in a vacuum. The Zero_HiddenHunger_EU project aims to 1) provide estimates of the true prevalence of MN deficiencies, based on priority biomarker and MN intake data in European populations and their associated health costs, focused on high-risk population subgroups, and 2) provide the best possible evidence to develop context-specific, tailored food-focused solutions to ensure adequate supply of vitamins and minerals from diets from sustainable sources. The consortium will focus the research effort around existing high-quality data resources and biobanks from diverse and representative population groups around Europe, supplemented by targeted studies in under-represented groups, maximizing research investment and adding value. Using high-throughput biomarker and advanced data analytical and modelling techniques, Zero_HiddenHunger_EU will deliver credible evidence enabling policymakers and food system actors to deliver food-focused strat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coupling of Optical tweezers with Tip-enhanced Raman Spectroscopy for single-molecule investigation of supramolecular systems' (TweeTERS).

assistant: **Concept**

Quantitative information on the dynamics and mechanistic principles behind supramolecular systems can be investigated in the single-molecule regime by measuring the nanometer displacements resulting from the application of picoNewton forces in optical trapping (OT) experiments. In particular, the mechanical strength of non-covalent interactions can be quantified when studying the reversible breaking/formation of hydrogen bonds on individual host-guest systems or the switching of a macrocycle between binding stations in a molecular shuttle. However, the fundamental chemical mechanisms behind the obtained real-time operational kinetics are not accessible with OT experiments and fundamental questions about the physicochemical processes underlying real-operation remain unanswered. The goal of this project is to merge OT for single-molecule optical force microscopy experiments with tip-enhaced Raman spectroscopy (TERS). TERS is a powerfull nearfield-based techinque based on the coupling of Raman spectroscopy and scanning probe microscopy. It provides chemical characterization with single molecule sensitivity and few-nm spatial resolution. Since Raman spectroscopy is sensitive to molecular species, inter and intra molecular interactions and orientations; by combining OT-optical force microscopy with TERS, we will access the underlying physicochemical processes triggering specific shuttling events in molecular motors and other types of supramolecular systems. In particular, we aim to create a hybrid tool that can disentangle the relation between mechanical, conformational and chemical properties of individual synthetic supramolecular systems and the non-covalent interactions governing their behavior, with single-molecule sensitivity and spatial resolution in the range of 10 nm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Consumer Goods Research Initiative - Networking European Technology Platforms addressing Design-based Consumer Goods Industries and Related Research and Technology Fields' to be submitted under Seventh Framework.

assistant: **Abstract**

Health of people, safety of workers, sport performance, new cultures and lifestyles, customised fashion products will be drivers to promote European Consumer Goods on the global market, exploiting the European historical culture and knowledge on manufacturing processes and products as well as the proactive European consumer market, always looking for new frontiers in terms of comfort, satisfaction, well being and leisure of consumers.The above mentioned major target applications are strongly related with major ongoing societal trends such as ageing, mobility & activity, globalisation, sustainability, etc.Thus, there is today a unique opportunity for the future of the European consumer goods industry: the creation of a new generation of healthy, safe, fashion and lifestyle products, and related services, full of new functionalities which offer a concrete response to needs and desires of consumers of all ages, interests and walks of life in Europe and worldwide.Within such a perspective, present proposal addresses the creation of synergies, the identification of common elements, and the development of a programme of commonly-defined activities in terms of socio-economic foresight, research & technology roadmapping & strategy development between the European Technology Platform for the Future of Textiles and Clothing, the European Footwear Products & Processes Technology Platform, the European Platform for Sport & Innovation, the European Forestry-based Technology Platform, and the ManuFuture Technology Platform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Latvian Researchers Mobility Centre establishing and operation'.

assistant: **Innovation**

The knowledge-based economy and RTD ask for an appropriate mobilisation of human resources. The researchers' mobility within the ERA will be one of effective solutions for this task. The Latvian Researchers Mobility Centre (Latvian RMC) operating within the ERA-MORE will be organised at the Latvian State Institute of Wood Chemistry, which is contractor of project RESMOB-LATVIA. To improve the situation and conditions regarding researchers' mobility, during project realization the following results will be achieved: establishing of the specialised Latvian Researchers Mobility Portal (Latvian RMP) in English and Latvian acting in cooperation with European RMP; establishing of a national-scale mobile researchers support system to provide personal assistance through the central Help desk or through advisory bodies with trained personnel and contact persons circle on the site (universities, scientific centres, etc.); organising of an information dissemination channels around the Latvian RMP; preparation and continuous up-dating of information dossiers, which will reflect all issues regarding incoming, outgoing and returning mobile researchers (legal and administrative regulation, daily life issues); popularisation of the targets and activities of ERA-MORE in society, especially in researchers' community. To support the achieving of these goals, appropriate market and promotion activities towards researchers and employers will be carried out to recruit new users of the offered services and partners of co-operation. A national steering group, composed of intersectional experts, will be set up to analyse the situation of researchers' mobility and its obstacles, and the preparation of recommendations for policy makers and institutions responsible for the policy realization. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High-dimensional electrical stimulation for visual prosthesis' (HYPERSTIM), addressing dissemination and exploitation.

assistant: **Impact**

Future advanced neuroprostheses will need to transfer orders of magnitude more information to the brain than currently possible. This is most urgently needed in visual prostheses. Improving the electrode count will be part of the solution: a next generation of visual prosthesis will most probably be based on the insertion of over 1000 microelectrodes in the visual cortex. Still, current visual prostheses use very simple stimulation patterns, in which at most the stimulation amplitude is modulated.We propose to explore a second, complementary approach to brute scaling: using the available electrodes more efficiently by applying sophisticated stimulation protocols. Our main objective is to achieve a fundamental breakthrough in the spatial resolution of electrical brain stimulation to restore vision, obtaining a resolution of at least 20X the number of electrodes that are physically present.The vast number of possible stimulation combinations calls for a radically new research methodology, integrating modeling and state-of-the-art neuroscience methods at every spatial scale (from single neurons to the entire brain) in a closed-loop optimization process. With this combination of techniques, we will study which stimulation patterns effectively induce sufficient neural activations in higher areas (i.e. ignition) and cause visual perceptions. Thus, we will be able to explore the vast, hyperdimensional search space of possible stimulation patterns, and produce a set of in vivo tested stimulation patterns that are capable of eliciting distinguishable physiological and behavioral responses.The obtained order-of-magnitude improvement in resolution will spur the development of breakthrough prostheses that will be widely adopted by blind patients, and bring the field of neural inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The multi-omics role of lipid transfer proteins in lipid metabolism' (LipTransProMet), addressing dissemination and exploitation.

assistant: **Impact**

Cellular membranes of eukaryotic cells vary in their lipid composition, which allows segregation of diverse biological processes and specific enrichment of signaling, enzymatic and structural proteins. Differential enrichment of lipids in different membranes stems from compartmentalized synthesis and degradation of lipids, but also from lipid transport between membranes. Lipid transfer proteins (LTPs) facilitate non-vesicular lipid transport through aqueous spaces, and their dysfunction can lead to diseases. They are crucial for many molecular processes because a large part of the proteome depends on membranes for its function. However, for the majority of the more than 100 LTPs in humans, the lipid cargoes, the integration into metabolism, the mode of action, and the targeted organelles remain unknown. The Gavin group recently performed large screens to identify the lipids bound and transported by LTPs, and during my first months in the host lab, I have been involved in the data analysis of these screens.Our primary objective in the current project is to take the next step by exploring the role of LTPs in lipid metabolism. We will evaluate the effect of LTP knockdown in cell lines with a unique combination of two complementary systems biology approaches: lipidomics and thermal proteome profiling. The integration of these data with previous data from the Gavin group and public databases will highlight lipid metabolic pathways that rely on LTPs for their correct function, and might decipher less obvious connections with other cellular pathways. Moreover, as additional results of this analysis, these data will likely also highlight relevant organelles and maybe even signaling pathways, even further establishing the functions of the LTPs. This project will enhance our insi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A strategy for the EuroPhysiome' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The Physiome Project is a grass roots" effort to provide a computational framework to facilitate the understanding of the integrative function of cells, organs and organisms that is being undertaken by the loosely coupled actions of a number of individual laboratories world wide. It aims to create an exhaustive multiscale in silico model of the human physiology. STEP is designed to provide coherence to European Physiome-related activities by creating an integrated framework, the EuroPhysiome, which, while remaining true to the Physiome concept, can accelerate the progress of the European teams by avoiding redundancy, enhancing compatibility, etc.By forming the individual actions into a collective European response, it will also enable issues such as common objectives, overall effectiveness and impact, dissemination, availability of resources and long-term sustainability to be addressed, for the first time, at a European level.STEP has recognised that tackling the whole physiome is too ambitious for a relatively small Coordination Action and will therefore exclude consideration of the brain and perceptual/cognitive aspects. Subject to this constraint, and with the assistance of the Physiome coordinators, STEP has gathered the existing European projects that are working under the Physiome umbrella into the current consortium. STEP has an inclusive philosophy and will be happy to include new projects, or existing projects somehow overlooked, into its activities.These will consist of two conferences and several focused discussions, for which Internet-based media will be widely used. STEP will have an Advisory Board containing eminent figures from the Physiome project and representatives of industrial organisations and professional societies. It will also set up an Expert Pa