RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Influence of dietary fatty acids on the pathophysiology of intrauterine foetal growth and neonatal development' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Prenatal nutrition is known to affect the health and development of the newborn child. A foetus that suffers intra-uterine growth restriction (IUGR) is more likely to suffer from cardiac or diabetic problems in later life, an effect known as metabolic programming". Particular fatty acids are required for development but the optimum composition of dietary lipids remains controversial. The project will compare normal and IUGR pregnancies in terms of marten, neonatal and placenta fatty acid profiles. Placental transfer of fatty acids in vivo and the functional ability of trophoblasts in vitro will be measured. The effects of dietary fats, on maternal endocrine status, oxidative stress, milk composition, placental function and on the development of IUGR and normal foetuses in uteri (or ex uteri in the case of the preteen infants fed intravenously) will be assessed. Humans studies will be complemented with appropriate rat and pig animal-models. The results will be used to formulate improved dietary recommendations for mothers throughout pregnancy and lactation."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Trial of a sheet stamping simulation system in the aluminium packaging and aerospace sectors' in the context of a Fifth Framework call.

assistant: **Objectives**

The objective of the project is to adapt a software program aimed at simulating the sheet stamping processes for steel panels within the automotive sector in order to diversify it for the simulation of the deep drawing of aluminium products destined for the monoblock packaging and aeronautics industries.The benefits for the targeted sectors will be:1. Make their development and/or production cycles more efficient by using a software tool2. Increase the quality and economic viability of the products;3.Enhance their design of the product and production cycle. The final outcome of the trial can be summarised as a validated software system containing unique capabilities simulation for the targeted sectors.Objectives:The objective of the project is to adapt a software program aimed a simulating the sheet stamping processes for steel panels within the automotive sector in order to diversify it for the simulation of the deep drawing of aluminium, products destined for the monoblock packaging and aeronautics industries.The benefits for the targeted sectors will be1. Make their development and/or production cycles more efficient by using a software tool, which is very easy to adapt to their environment and 2.Increase the quality and economic viability of the products by enhancing the design of the product and production cycle by using state-of-the-art simulation software.These benefits will allowWork description:The project provides for an identification stage during which end-users can define their short-term and long-term aims within the project. In the short-term the software will be installed within each company, training will be provided and initial trial will begin. This phase will require help from suppliers in order to address the needs of the end-users. This period is a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Future leaders in ageing and digitalizing societies' (Digi4Age).

assistant: **Concept**

The digitalisation of ageing societies is restructuring Europe, raising concerns about social inclusion. Recognizing the gravity of this shift, the EU declared the 2020s 'Europe’s Digital Decade', while the WHO declared it the 'Decade of Healthy Ageing'. Researchers and practitioners typically view digitalisation and societal ageing as separate shifts. Digi4Age breaks with this tradition. Drawing on its members’ recent research, it posits that both are intertwined. They are jointly experienced and integrated into the social fabric – and they need to be jointly addressed. Digi4Age trains 14 doctoral researchers as future leaders with scientific expertise in both digitalising and ageing societies, who can creatively steer academia, the public sector, private sector, and civil society towards solutions benefitting older individuals, European societies, and businesses. To do so, it launches an interdisciplinary, intersectoral and international doctoral research and training programme for excellence in evidence-based leadership in digitalising and ageing societies. The programme explores how digital technologies can (1) support health in old age without compromising identities and self-images; (2) accommodate older individuals’ long-standing habits and preferences in workplaces and consumer markets; and (3) complement social innovation to ensure equality and social inclusion in ageing societies. Digi4Age assembles some of Europe’s foremost researchers in this area as beneficiaries (LUT, OUNL, LSMC, TUDO, OSLOMET, URJC, KLPU) and influential researchers and widely recognized stakeholders from civil society, policymaking, and businesses as associated partners (LRS, VILANS, UH, VICESSE, AGE, vdSHOP, HZG, OEI, VTT, TUWIEN, NIPH, SENIORWORLD, EUROCARERS) across 9 countries. It ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Therapnea: Novel Therapy to treat Obstructive Sleep Apnea based on Thomas Oro-Pharyngeal Stent' to be submitted under Horizon 2020.

assistant: **Abstract**

Obstructive sleep apnea is the most common organic sleep disorder in which the respiratory path becomes occluded during sleep, usually due to collapse of the upper airways, causing the patient to stop breathing, with severe co-morbidity issues.Although there are several known therapies for apnea (behavioural, devices or surgery), none is as successful and effective as using compressed air respiratory support to keep the airways open during sleep, making CPAP (Continuous Positive Airway Pressure) the most common treatment of choice. Unfortunately, it still has many limitations regarding patient’s compliance, and it is ONLY SUCCESSFUL FOR 50% OF PATIENTS.According to the World Health Organisation (WHO), over 100 Million people worldwide suffer sleep apnea and its related morbidity and mortality risks. Tens of millions are unable to adhere or abandon current therapies, with CPAP as the first line of treatment. Low CPAP compliance, mainly due to major discomfort, is recognized as the major issue, and many companies are investigating ways to improve it. Sleep apnea devices market size is worth USD 8.8 billion by 2023, with 7.7% CAGR from 2016 to 2023.We at Thomas Medical Ltd. have been working on the development of a disruptive solution to respond to the unmet needs of patients that can’t adhere current therapies. The invention is an upper airway stenting device intended for the treatment of adult obstructive sleep apnea. The device, Therapnea™, operates by providing mechanical support to the walls of the pharynx and the back of the tongue, thereby preventing their collapse and eliminating partial or complete airway obstruction during sleep. We aim to provide effective therapy to the tens of millions of sleep apnea patients who can’t be helped with current CPAP devices or su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Electrochemistry and corrosion science for the environment' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Applications are invited for post-graduate positions. The Fellows will be based at the University of Milan, Department of Physical Chemistry and Electrochemistry, Electrochemical Laboratory. Milano is located in an economically live area, thus providing the opportunity of stimulating contacts. A wide choice of research themes is available, summarized under the following general subjects: electrocatalysis and electrode materials; organic electrosynthesis; colloid and surface science; corrosion; environmental electrochemistry; transport phenomena in conducting media; electroanalysis; equilibrium electrochemistry. Within each general subject the research will focus on selected topics, the complete and updated list of which can be obtained at the ECSE site: http://users.unimi.it/ecse or by e-mail to ecse@unimi.it. A selection of the currently available topics is listed here below: Composite materials for hydrogen evolution electrodes Electro catalysis on silver for organic halide electro reductions Mixed oxide electrodes for oxygen evolution Air cathodes for power sources Properties and applications of boron-doped electrodes Surface acid-base properties of electro catalytic oxides Electro reductions for bioconversion precursors Physico-chemical studies on microcrystalline cellulose for pharmaceutical applications Sol-gel techniques for the preparation of tailored dispersed materials Adsorption of ionic and non-ionic surfactants at the liquid-liquid and solid-liquid interface Mechanisms of corrosion processes and inhibitor efficiencies in aqueous media Electrolytic processes for detoxification of wastes Liquid junction potentials in mixed aqueous/organic solvents Self-assembled-monolayer modified electrodes for voltammetric sensors pH and rH standardization in mixed aqueous/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Attenuated viruses and protective immuneresponse in European long-term surviving hiv infected children' (1994-1998) under Fourth Framework.

assistant: **Objectives**

- To examine the frequency of possibly attenuated HIV variants in long term surviving (LTS) HIV infected children and to characterize these viruses on a biological and molecular level.- To analyze the HIV specific humoral and cellular immunity in LTS HIV infected children in order to characterize presumably HIV protective immunity.At least two different clinical courses can be observed in vertical HIV-1 infected infants. One group progress to AIDS within the first two years of life whereas a second one experience a slower disease progression. Within this latter group, epidemiological surveys have identified children defined as Long Term Survivors (LTS) experiencing very slow or no disease progression. In the frame of the European Concerted Action on Determinants of disease progression in HIV-1 infected infants" a large cohort of HIV-1 infected children who can be defined as LTS have been identified. The analysis of genetical, immunological, as well as virological characteristics of this group of infected children may shed light on the mechanisms of protection from disease progression and ultimately be used to tailor immunological therapies. The following virologic and immunologic factors contributing to clinical and biological steady state possibly present in LTS children will be evaluated: 1) quantitative viral RNA and DNA content in specimens 2) differential content of viral mRNA species 3) isolate susceptibility to inhibitory by chemokines 4) levels of neutralizing antibodies to autologous virus isolates 5) levels of CD8+ T cell/chemokine mediated virus replication inhibition. These analyses will classify the children in the LTS cohort in groups according to the level of time-associated changes in viral parameters. Individuals with the lowest and the highest changes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Big data against childhood Obesity' in the context of a Horizon 2020 call.

assistant: **Objectives**

Childhood and adolescent obesity is a major global and European public health problem. Currently, public actions are detached from local needs, mostly including indiscriminate blanket policies and single-element strategies, limiting their efficacy and effectiveness. The need for community-targeted actions has long been obvious, but the lack of monitoring and evaluation framework and the methodological inability to objectively quantify the local community characteristics, in a reasonable timeframe, has hindered that. Fortunately, technological achievements in mobile and wearable electronics and Big Data infrastructures allow the engagement of European citizens in the data collection process, allowing us to reshape policies at a regional, national and European level. In BigO, that will be facilitated through the development of a platform, allowing the quantification of behavioural community patterns through Big Data provided by wearables and eHealth- devices. During the project, BigO will reach out to more than 25.000 school and age-matched obese children and adolescents as sources for community data. Comprehensive models of the obesity prevalence dependence matrix will be created, allowing, for the first time the data-driven effectiveness predictions about specific policies on a community and the real-time monitoring of the population response, supported by powerful real-time data visualisations. In short, BigO will provide an innovative new suite, allowing the Public Health Authorities to evaluate their communities based on their obesity prevalence risk and to take local action, based on objective evidence. BigO does not aim to redefine, from the ground-up, the existing obesity-related policy strategies targeting childhood obesity prevalence. BigO does, however, aim to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Compaction in cattle embryos: a genetic, molecular and cellular analysis to combat reduced viability of in-vitro produced -IVP- embryos' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Application of developments in the new genetics", ranging from genome sequencing to the use of "ovum pick-up" from cows of high genetic merit, is dependent on a supply of viable in-vitro produced (IVP) embryos. Embryo-based technology in cattle has enormous potential and is being commercialized in every EU country but many of the small or medium size embryo-based biotechnology companies are finding it difficult to survive because of viability problems with IVP embryos. While the in-vitro fertilization rate is high (80%), only about 30 embryos are produced from every 100 fertilized oocytes, and following transfer to recipients the pregnancy rate is 35-40% compared to 60-65% for in vivo produced embryos. Following cryopreservation the viability of IVP embryos is even further reduced, resulting in pregnancy rates as low as 20-40% and this is a significant limitation in a commercial context. A major factor reducing IVP embrya viability is their failure, in a high proportion of cases, to undergo compaction and normal cell junction formation in the manner of in vivo embryos. Compaction, when cell-to-cell contact is made for the first time followed by the formation of tight intercellular junctions to form a barrier against the extra-embryonic environment, represents the first critical morphological stage when the embryo begins to function as a unified organism. A high proportion of IVP embryos fail to undergo compaction but 'jump' from noncompacted 16-32-cell stages to the blastocyst stage at day 8 resulting in delayed development and low viability. Despite the physiological and economic importance of compaction there is a lack of information on this critical event in cattle embryo development. The objective is to determine the nature of the genetic, molecular, metabolic and/o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Partially Submerged Propellers project' in the context of a Fourth Framework call.

assistant: **Objectives**

The aim of PSP project (Partially Submerged Propellers project) is to develop a new technology for the design and the manufacturing of highly efficient and innovative ship propulsion system. The intended propulsion system is mainly characterized by large and particular propeller, purposely designed to operate partly submerged for some or all the expectable loading condition of the vessel. Ships provided with PSP may also be distinguished by a peculiar design and arrangement of stern forms, rudder, tailshaft, reduction year box and main engine.Energy savings connected with the application of the PSP concept are expected to be remarkable (in some cases more than the 30%). The relevant economic, industrial, social and environmental effects are therefore expected to be extremely interesting. In view of the extreme degree of innovation, difficulties and risk involved, it is considered that the intended research project and the development on vast scale of the proposed new propulsion system will require comprehensive investigations to be supported by suitable experimental tests both with models and in full scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spatial and temporal biotransformation of micropollutants in a lake ecosystem' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Freshwaters are increasingly contaminated with a variety of pesticides, pharmaceuticals, personal care product ingredients and industrial chemicals referred as “micropollutants” (MPs). Most of these MPs are poorly retained by wastewater treatment plants, and thus are released into natural water bodies, where they can travel all the way to the raw water of drinking water treatment plants. Very little information is currently available on the persistence and transformation of MPs in lake ecosystems. This project aims to investigate the fate of twelve MPs in lake Greifensee in Switzerland by measuring their transformation rates at different depths and seasons. To this end, lake water will be sampled at different depths in Lake Greifensee, and natural microbial communities (bacteria and phytoplankton) will be exposed to a mixture of different MPs using semipermeable plastic bags that will be redeployed to their original depth. The bags will let gases, salts and ions be exchanged with the outside environment, but will retain MPs and microorganisms inside the bag. At regular intervals, MP concentrations and their transformation products in the bags will be determined in order to calculate biotransformation rates of MPs at different depths of the lake. Phytoplankton and bacteria communities will be analyzed to assess the role of microorganisms in MP transformation using cutting edge “omics” methods such as metagenomics. This project will be unique in that it actually quantitatively describes the extent of MP biotransformation in situ, and thus eliminates many of the uncertainties involved in estimating in-field biodegradation based on laboratory experiments. It will also bring more in-depth knowledge on the drivers of biotransformation, whether they are of bacteria or phytopla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Let's give the world appetite for health' (ProteinPlus).

assistant: **Concept**

Disease-related malnutrition affects 33 million Europeans, a burden of 170bn€ for the EU. Oral Nutritional Supplements (ONS) are specially formulated foods designed to meet patients’ nutritional deficiencies during illness. This $10Bn ONS market is dominated by Nutricia, Nestlé, Fresenius & Abbott.However, large portion sizes and bad taste in ONS induce very low levels of treatment compliance (50%), dramatically limiting effectiveness. Manufacturers face a technological barrier that prevents them from increasing protein density and thus reducing volume.The aim of the project is to bring to the market a disruptive hyperproteinic ingredient – Protein Plus© - for ONS manufacturers, that overcomes this technology gap.Founded in 2004, EMULSAR invented and patented its Smart Emulsion Nanotechnology© (SENT©), used to manufacture disruptive ingredients for health and nutrition. Since 2012, SENT© has produced hundreds of tons of food ingredients (used by Casino, Unilever…to create healthier & tastier products), proving its industrial sustainability and compatibility with commercial food standards.In Phase 1, we proved (at lab-scale) that by applying SENT© to proteins, we can produce a protein-dense ingredient that makes it possible to reduce current ONS volumes by half.Our Phase 2 objectives are to optimize our Protein Plus© ingredient, validate the industrial process, establish clinical proof of improved ONS compliance & prepare our market launch.Our project will improve the competitiveness of ONS products, create public healthcare savings and enhance Europe’s health capital.  For EMULSAR, the ONS market is the best path for becoming a European technology leader in health food, allowing EMULSAR to transition from nice-to-have applications (mass-market food) to must-have applica