RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Individualizing statin therapy by using a systems pharmacology decision support algorithm' under Horizon 2020.

assistant: **Concept**

Background: Statins are essential drugs in the treatment of hypercholesterolaemia and are among the most prescribed drugs worldwide. The response to statin therapy varies widely between individuals. While most patients show good efficacy, a significant proportion of individuals show poor or even a lack of cholesterol-lowering efficacy. Moreover, a number of patients experience adverse drug reactions. These together with the lack of immediate effect on well-being likely explain the relatively poor adherence to statin therapy. Poor adherence to statins in turn increases the incidence of cardiovascular events and mortality.Aims: The objectives of this project are 1) to develop a systems pharmacology model for predicting statin efficacy and tolerability at the level of an individual patient and 2) to investigate whether selecting the statin based on the model improves treatment adherence.Methods: A systems pharmacology approach will be used to integrate data from in vitro and clinical studies. Semi-physiological pharmacokinetic-dynamic-toxicologic models will be built for each statin allowing the prediction of the pharmacokinetic and clinical outcomes for patients with different characteristics, genotypes, and concomitant medications. The ability of the systems pharmacology algorithm to enhance adherence will be investigated in a randomized clinical trial.Significance: Systems pharmacology models have been increasingly applied in drug development, for example to predict the effect of organ dysfunction on pharmacokinetics. The proposed project is the first to use systems pharmacology predictions to guide clinical drug therapy, thus going beyond the state of the art. If successful, the project will not only improve the prevention and treatment of cardiovascular disease, but i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Deconstructing Adaptive Piezoelectric Responses in Pathological and Healthy Microenvironments', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Tissues are piezoelectric materials, generating electrical signals in response to mechanical stress, and yet this important aspect has not yet been incorporated into the design of disease research models, particularly in conditions like idiopathic pulmonary fibrosis (IPF). Piezoelectricity affects cellular migration, growth, and differentiation. However, most of our understanding of cell-tissue interactions comes from studying cells under ‘static’ mechanical conditions. Cells interact with their microenvironment by applying forces and receiving bioelectric feedback through ion channels, which are overexpressed in fibrotic tissues (16-fold). Because macrophages and fibroblasts are involved in IPF-related fibrogenesis, we hypothesize that piezoelectricity plays a critical role in their differentiation states during disease progression. Current IPF research models do not replicate the electro-mechanical cellular environment, widening the gap between predictive in vitro models and clinical outcomes. Bridging this gap requires a paradigm shift toward models that incorporate electro-mechanical coupling. With DAPHNE, the applicant will develop a state-of-the-art piezoelectric platform providing both electrical and mechanical signals, enhancing the physiological relevance of current models. This innovation will accelerate drug development by enabling the testing of novel anti-fibrotic therapies targeting ion channel activity and creating the first statistically powerful library of cell-ECM electro-mechanical interactions. At the core of DAPHNE is the ReShape platform, which integrates three key functions:•   Force: Applying dynamic forces to modulate piezoelectricity and cellular activity.• Visualize: Using real-time, label-free Fluorescence Lifetime Imaging Microscopy (FLIM) t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cavity Quantum Optomechanics' (CQOM), addressing dissemination and exploitation.

assistant: **Impact**

Over the past year a new research field has emerged: cavity Optomechanics which brings the quantum regime of mechanical oscillators in reach and may allow to explore new fundamental measurements concepts, may lead to novel transducers and test quantum mechanics on a macroscopic scale. In this research field, which utilizes mechanical oscillators coupled to laser fields, Europe has played a pioneering role. The distinguishing feature of this ITN training network is that the partners are active in this research field (cavity Optomechanics), which facilitates and indeed leverages the collaborative effort and will make this ITN highly effective. Cavity optomechanics is moreover a field which is highly faceted in terms of the required and offered training skills that spans quantum optics, nanofabrication, finite element simulation and cryogenic expertise and techniques as well as quantum theory. To effectively train new students it is therefore pivotal to train students in all relevant skills and techniques and theory. The realization that a single group is much less efficient than a consortium is the major driving force behind the ITN network. It will provide a streamlined, high quality-training program that offers a remarkably diverse set of skills. This training program will be of immediate benefit to the partners that will thereby obtain a superior training of their PhD students, which therefore provides a build-in mechanism that will ensure the effective realization of the proposed ITN training program and it success. The existence of such a training program, which will be opened to international groups, will contribute to the visibility of the EU cavity optomechanics community in an international setting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Energy Sector Innovation Financial Network' (EIFN).

assistant: **Concept**

According to the EU innovation and energy policies a comprehensive network for a better understanding between energy enterprises and institutions and financial agents will be designed and developed based on the following criteria:- Collaboration to update the financial services to the energy sector innovation needs.- Provide practical and efficient solution to facilitate innovation agents in the energy sector the access to financial services.The main objectives of this project are:- Improving the access of entrepreneurs (energy technologies) to financial services.- Promoting the collaboration between innovation agents and the financial service providers.The project scope includes:- Establishment of a stable collaboration EU innovation financing network for energy projects. The members of this Group would be enterprises, scientific institutions, universities, energy agencies, private and public financial institutions.- Identification and analysis sector characteristics in relation to innovation financing and establish European map linking needs of sectors and funding sources.- Develop methodologies, tools, guidance materials and procedures to improve the access of energy research players to innovation financing.- Workshops and roundtables organisation to identify relevant issues and receive feedback from the market agents.- IT infrastructure development to support the designed methodologies, tools and procedures.- Co-ordination with other relevant EU initiatives: Gate2Growth and PAXIS.- Elaborate policy and operative recommendations to the EU innovation policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Generation of ultra-deep libraries of transcriptional activators for gene therapy'.

assistant: **Objectives**

We have generated a novel genetic circuit that, by combining an unusual site-specific recombinase and molecular splicing, allows to functionally diversify modular proteins in-vivo in a highly-directed manner. Applying this method to modular transcriptional activators allowed us to generate billions and even trillions of transcription factors variants in-vivo starting from a single base construct. The aim of the DIVERGE PoC project is to to explore the commercial potential of this approach for the isolation of transcriptional activators for human gene activation therapy and to establish a strategy for commercialisation of current and conceivable future implementations of this technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Topographically guided placement of asymmetric nano-objects' (TOPOPLAN).

assistant: **Concept**

The controlled synthesis of nanoparticles in the form of spheres, rods and wires has led to a variety of applications. A much wider spectrum of applications e.g. in integrated devices would be available if a precise placement and alignment relative to neighbouring particles or other functional structures on the substrate is achieved. A potential solution to this challenge is to use top-down methods to guide the placement and orientation of nanoparticles. Ideally, a precise orientation and placement is achieved for a wide range of particle shapes, a so far unresolved challenge.Here we propose to generate a tunable electrostatic potential minimum by exploiting double-layer potentials between two confining surfaces in liquid. The shape of the potential is determined by the local three-dimensional topography of the confining surfaces. This topography can be precisely tailored using the patterning technology that has been developed in our research group. The potential shape can be adapted to fit to a wide range of particle shapes. The trapping energies exceed the thermal energies governing Brownian motion and trap and orient particles reliably. After trapping, the particles are transferred in a subsequent step onto the substrate by external manipulation.The separation of the trapping and placement steps has several unique advantages over existing strategies. High aspect ratio structures or fragile pre-assembled structures like nanoparticles linked by DNA strands can be pre-aligned in the trapping field and placed in the desired geometry. For applications like the placement of quantum dots into high fidelity cavities, the trapped particles can be examined optically and repelled if the spectral properties do not match. In particular the precise positioning of nanowires is prom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nano-Engineered Fiber-Reinforced Polymers', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Fiber-reinforced polymers (FRP's), stronger per unit of weight than steel or aluminium, are highly demanded for high-performance applications. The use of FRP's in aerospace structures can lead to a significant reduction of maintenance costs, carbon imprint by fuel consumptions, COx and NOx emissions, etc. This is the reason why the last civil Airbus aircraft contains up to 52% in weight of composite materials and the Boeing 787 Dreamliner claims to be the first aircraft with a fully composite fuselage. However, composites materials presents several drawbacks that need to be overcome to fully take advantage of their excellent mechanical properties. From a mechanical perspective, aerospace composites are made of carbon fiber “plies” which are held together by a polymer. This polymer can crack easily, which results in the delamination of the plies and the failure of the structure if it is not detected on time. It is also required for aerospace materials to be protected from common environmental occurrences, such as lightning strikes, electromagnetic interferences, electrostatic discharge, etc. Various methods are used to address these concerns, such as the use of metallic meshes or foils. However, these meshes/screens are difficult to handle for both production and repairs, and increase significantly the overall weight of the aircraft. Here, I propose to develop a novel nano-architecture to enhance the mechanical and electrical properties of the composite in the through-the-thickness direction.  This nano-architecture will also act as a sensing system, enabling damage detection and localization by resistive-heating based non-destructive evaluation. In summary, the nano-engineered composite proposed here is an intrinsically multifunctional material, with expected over the s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reengineering airline critical processes', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In an airline, Flight Operations is the business process that ensures that every flight is operated according to the schedule, with the appropriate type of aircraft and a with fully-qualified crew. All major European airlines are now facing the task of redesigning their Flight Operations processes in order to support the new demands of a deregulated transportation world. However, any attempt to reengineer Flight Ops must address three constraining issues:Flight Operations is highly critical : when it breaks down, even for a few hours, the airline loses huge amounts of money. Software migrations cannot be allowed to threaten the availability of the process. Flight Operations is the most complex process of the airline. It involves dozens of departments, thousands of employees and hundreds of computer applications. Efficient co-operation and workflow are especially difficult to achieve.Flight Operations involves the management, the planners, the crew-members and the IT staff. The need for a consensus among these groups often translates into a strong resistance to change. Efficient change management is a key factor of success.The objectives of the RAP project are to make it possible to reengineer Flight Operations in spite of these difficulties. These objectives will be reached as follows :The RAP project will produce a tool for ensuring the safe migration from legacy Flight Operations systems. The tool will rely on so-called mirror databases, i.e. devices that make it possible to run new applications in parallel with the legacy applications which are being replaced.The tool will be a generic one : any airline will be able to re-use it into its own IT environment with a small systems integration effort. It will not duplicate commercially-available products, and will be appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A portable peritoneal dialysis system for home use that monitors for infection' in the context of a Horizon 2020 call.

assistant: **Objectives**

End Stage Kidney Disease (ESKD) or End Stage Renal Disease (ESRD), the fifth and last stage of Chronic Kidney Disease (CKD), is recognised as a major public health problem. It occurs where kidneys are no longer capable of sufficiently filtering waste products from the blood. With kidney function at less than 10 %, a kidney transplant or an external means of filtering is needed. The latter consists of either Haemodialysis (HD) or Peritoneal Dialysis (PD). Globally, we are seeing an increasing prevalence in ESRD. This is caused by an aging population in the west, socio-economic factors, increasing hypertension, and growing diabetes and obesity epidemics.The technical complexity of market offerings can inhibit many patients from choosing PD. HD takes an average of 4 hours per treatment session and occurs 3 times a week while PD occurs 4 times a day with each exchange requiring 40 minutes on average. Most dialysis occurs in specific dialysis centres and hospitals, adding further time for travel. Non-compliance with treatment schedules are a particular issue with PD. This makes it difficult for doctors to calculate correct treatment plans as patients may not share this information with their doctor. Non-compliance can be as high as 53%, decreasing efficacy of the treatment leading to poorer health overall and speeds up rate of decline.liberDi revolutionises traditional Peritoneal Dialysis with LPPDS, a smart, real-time, patient-monitoring, truly portable device. It’s lightweight, easy to set up and allows patients carry out their dialysis at home, at work or while travelling. LPPDS has UX at the very core of its design to ensure ease of use: patent pending smart automation, catheters and sterile connectors. The system consists of a patent-pending disposable that holds a smar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High sensitivity, portable photonic device for pervasive water quality analysis' (WaterSpy) under Horizon 2020.

assistant: **Objectives**

Pervasive and on-line water quality monitoring data is critical for detecting environmental pollution. However, it’s not easy to gather such data, at least not for all contaminants. Currently, water utilities rely heavily on frequent sampling and laboratory analysis in order to acquire this information.For this situation to be improved, portable and high-performance devices for pervasive water quality monitoring are required. Towards this end, there has been growing interest in expanding spectroscopic methods beyond the 2μm range of the infrared spectrum. That region of the spectrum is home to many vibrational & rotational absorptions of compounds related to water quality. Unfortunately, water itself is a strong absorber of infrared light. Thus, such methods were restricted to laboratory settings until now.WaterSpy addresses this challenge by developing water quality detection photonics technology suitable for inline, field measurements, operating in the 6-10 μm region. The solution is based on the combined use of advanced, tuneable Quantum Cascade Lasers and fibre-coupled, fast & sensitive Higher Operation Temperature photodetectors. Together with these new components, optimized laser driving and detector electronics as well as laser modulation concepts will be developed. Attenuated total reflectance spectroscopy will be used to give rise to the biochemical profile of the surface chemistry of the sample. Targeted analytes will be specific heterotrophic bacterial cells. Several novel techniques are employed in order to increase the SNR, including antibodies capable of binding the targeted analytes and a novel pre-concentration method. WaterSpy technology will be integrated, for validation purposes, to a commercially successful water quality monitoring platform, in the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An EU - New Zealand Research Collaboration to Develop Synergies and Make Cutting-edge Breakthroughs in Yacht Engineering' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The experienced senior researchers involved in the present proposal are members of global leading research groups in the fluid dynamics of sailing yachts. All of these three groups perform research, teach, and deliver consultancies in the field of fluid dynamics applied to sailing yachts. They have complementary specialist expertise, laboratories, and numerical modelling tools. For instance, UNEW has a towing tank, which allows the hydrodynamic forces acting on model-scale yachts to be measured, UOA has wind tunnels, which allow the aerodynamic forces on model-scale sails to be measured, and ECONAV has instrumented yachts where full-scale measurements of the aerodynamic forces are possible. It is expected that long-term collaborations between these three groups will be highly beneficial to each of them in order to develop new collaborative cutting edge research, and to enhance the knowhow and expertise of each participant. Also, these three global leading research groups aim to create an International Association of Yacht Engineers, which will promote and coordinate networking and activities for the promotion of research outcomes in the fluid dynamics of yachts. This will enhance the impact of the research in the yacht industry, and will facilitate the transformation of the research outcomes into technological innovations.In summary, the objectives of the proposal are as follows:1. Gain new breakthroughs in the fluid dynamics of yachts through the synergy of collaborative research effort;2. Enhance the expertise of the participants through the knowledge transfer of their complementary specialist expertise;3. Enhance the impact of the research on the yacht industry and facilitate the transformation of research outcomes into technological innovations;4. Enhance the cross-