RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The tRNA epitranscriptome: a novel player in viral infections'.

assistant: **Innovation**

Recent evidence indicates that codon usage bias regulates gene expression, as synonymous codons are not decoded with the same efficiency. Viruses are entirely dependent on the host translation machinery to express their proteins. Puzzlingly, the genomes of diverse viruses synthesize viral proteins at high levels, such as those of the emerging Chikungunya virus (CHIKV), dengue virus (DENV) and the pandemic SARS-CoV-2 are enriched in rare codons that should slow down their translation. How these viruses achieve this high protein expression remains a fundamental question in virology. In Juana Díez's laboratory, recent findings have revealed an unprecedented interplay of the Chikungunya virus (CHIKV) with the host tRNA epitranscriptome. CHIKV adapts the host translational machinery toward viral codon usage by overexpressing a tRNA modification enzyme that favors translating a specific set of codons enriched in CHIKV RNA.The proposed project will combine cellular, and molecular biology approaches with -omics analyses to further develop this novel research area and explore its translatability. First, using SARS-CoV-2 as a model, we will study whether the observed CHIKV-induced codon-specific reprogramming of the host translation machinery represents a common mechanism to optimize viral protein expression. Second, we will characterize the tRNA modifying enzymes involved. Third, we will explore the antiviral therapeutic interest of the identified enzymes. Together, these findings will shed light on a novel layer of virus-host interaction and might provide a rationale to consider the regulation of the host tRNA epitranscriptome as a promising target for the development of broad-spectrum antivirals.


**Keywords:** SARS-CoV-2, coronaviruses, RNA viruses, Translatome, Transcriptom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Anthropology of Human Security in Africa'.

assistant: **Objectives**

ANTHUSIA is a multi-disciplinary EJD in the Anthropology of Human Security in Africa proposed by a consortium of fouruniversities in Aarhus, Edinburgh, Leuven and Oslo. Combining competences from Anthropology, Human Security andAfrican Studies It aims to foster talent relevant to current challenges and potentials of developing safe societies in Africa. Byexploring different areas from a human security perspective, the research will provide insights into problems such asexpanding young populations, accelerated urbanisation, unequally distributed growth, recurring conflicts, persistent healthproblems, and refugee insecurity. A human security perspective shifts the focus from the security of nation states to thesafety and well-being of humans in their everyday lives. Human security problems, as well as growth rates in Africa haveobvious ramifications for European home security and economy. Refugee crises due to human insecurity in the Africancontinent are likely to continue evolving in the future.We propose 15 ESR projects converging in a comprehensive understanding of human security. These address epidemics,borderlands, infrastructure, economic/livelihood security, environmental/climate change, land and resource issues, andpolitical security – and the inter-linkages between them.To enhance the research findings’ policy impact, ANTHUSIA has partnered with organizations offering secondments, andwill train them to do innovative dissemination. ANTHUSIA’s central African hub is the British Institute of East Africa, whichwill host workshops and summer schools.Each ESR is supervised by two senior researchers from two universities, will do one year of empirical research in Africa,including 3-5 months of secondment, participate in PhD courses and disseminate research in a thesis a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel somatic mutations in ABCA1 in chronic myelomonocytic leukaemia' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Background: Altered high-density lipoprotein (HDL)-cholesterol homeostasis has been observed in hematologic malignancies but genetic evidences proving causality have been lacking. The ability of HDL to promote cholesterol efflux depends on two ATP-binding cassette transporters ABCA1 and ABCG1, which exhibit anti-myeloproliferative activity in preclinical mouse models.Hypothesis: Somatic mutations in ABCA1 and ABCG1 may be observed in myeloproliferative disorders and could be functionally inactive disabling both cholesterol efflux and anti-tumor activity.Preliminary data: Five new somatic mutations in ABCA1 were identified out of 26 tumor samples from patients with chronic myelomonocytic leukaemia (CMML) with an unexpected frequency of 19% and conferred a proliferative advantage when transfected into HEK293 cells.Aims: The aim of this study is to 1) test the functional relevance of newly identified ABCA1 mutants on myeloproliferative diseases and 2) apprehend the molecular mechanisms that could provide a proliferative advantage to these mutants.Methods: We will take advantage of the generation of these mutants to test their relevance (Aim. 1) and mechanisms of action (Aim. 2) both in vitro in relevant myeloblast cell lines and in vivo by performing a transplantation of bone marrow cells transduced with these mutants.Keywords: Leukaemia, HDL cholesterol, ATP-binding cassette transporters, human somatic mutations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dark Matter and Dark Energy in the Universe' under Fifth Framework.

assistant: **Concept**

One of the biggest challenges in present day cosmology is to explain the missing mass" which forms over 95% of the content of the universe. This emerged as important in the 1970's when astronomers compared systematically the gravitational masses of galaxies and galaxy groups with their total content of stars gas and dust, finding that over nine tenths of the gravitational mass could not be accounted for. It was also realised that the discs of spiral galaxies would be unstable without the presence of a massive dark halo. Then the inflationary model which explains the observed isotropy of the cosmic microwave background (CMB) radiation, implies a "flat" universe while the light element abundances predicted in the standard model Big Bang cosmology show measured values implying that "normal" baryonic matter can make up less than 5% of the mass needed for the universe to be flat.Our best models accounting for the observed large-scale distribution of mass and velocity of galaxies and clusters start with density fluctuations in an inflationary universe, and require a dominant mass component of non-baryonic matter non-relativistic at the time of its decoupling from the background radiation. The best of these "cold dark matter" (CDM) models, however, reque a CDM density only -30% of that required to close the universe, in apparent contradiction with inflationary predictions. This discrepancy was dramatically addressed by the discovery, using supernovae as standard distance candles that the universe is apparently accelerating. The vacuum energy which can produce this acceleration can also account for the -65% of the gravitational field not produced by baryonic matter or CDM, while the flatness of the universe was recently confirmed by measurements of the power spectrum of CMB flu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Atmospheric Behaviour and Environmental Fate of Semivolatile Pesticides; Heterogeneous Oxidation and Photochemical Degradation' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Due to growing awareness (and legislation) there is currently high interest in the atmospheric behaviour and environmental fate of trace-level semivolatile organic pollutants, such as pesticides. However, comprehensive studies on their atmospheric behaviour are limited and are hard to obtain due to the tendency of such compounds to adsorb to the walls and surfaces of experimental apparatuses. Thus, although previous studies indicated that a major portion of applied pesticides wind up in the atmosphere, this i s the medium about which we know the least regarding pesticide fate. We propose to addresses this issue by applying a powerful combination of spectroscopic techniques (ATR-FTIR and long pass IR chamber), which will enable simultaneous monitoring of the gas and condensed phases, in order to gain fundamental information on the reactivity of such semivolatile organic compounds. The proposed research will focus on the oxidation (by O3 and OH radicals) and photolysis of commonly used pesticides, in the gas phase, in the condensed phase, and adsorbed on materials that are typically found in the atmosphere (e.g., aerosols).The results from these studies (including identification and characterization of volatile and non volatile products) will significantly contribute to a more reliable risk assessments of these pesticides. To further understand the impact of pesticides in the atmosphere, we propose to investigate (using the same apparatus) the effect of pesticides adsorption on atmospheric aerosols on the physical and chemical properties of the later. This information is very important as aerosols play a major role in atmospheric chemistry, radiative balance and human health, and therefore changes in their properties are likely to affect tropospheric chemistry, climate, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Climate change, climatic variability and Agriculture in Europe: An integrated assessment' (1994-1998) under Fourth Framework.

assistant: **Objectives**

To provide an integrated assessment of the effects of climate change and climatic variability on agriculture in Europe. Research will follow two main themes: (i) the advancement of fundamental research on mechanistic crop-climate modelling, and (ii) the development of methodologies for scaling up site-based crop models to investigate regional climate change impacts.Current crop-climate research will be extended by improving the performance of existing crop models in extreme conditions and by considering climate change impacts on yield quality as well as general crop physiology. Specifically, experiments on the effects of high temperature events on wheat growth, high temperature events and drought on soya bean growth and elevated CO2 on grapevine growth and yield quality will be performed. All experiments will be conducted in the first half of the project to ensure that results can be used directly to refine and calibrate the relevant crop models. Methods will be developed for applying mechanistic crop models at a hierarchy of scales to enable a full evaluation of the effects of climate change on regional, national and continental agricultural production. Specifically, analyses will be conducted at four principal scales: (i) complex mechanistic crop models will be run at a number of sites throughout Europe; (ii) complex and reduced form mechanistic crop models will be applied at the regional scale for a number of case study regions in Europe; (iii) simplified mechanistic crop models will be developed at the national scale for Denmark, Finland, Hungary, Spain and Great Britain; and (iv) less data intensive mechanistic crop models will be developed at a 0.5 latitude/longitude resolution across Europe. Site-specific and spatial impact models will be developed in parallel. P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The rethinking of dyeing as fundamental and applied research training for sustainable fabric and food processing: Development of novel biogenic dyes for classical and innovative application' (DyeAnotherWay) targeting Horizon Europe.

assistant: **Abstract**

DyeAnotherWay aims at providing Doctoral Candidates with the skills necessary to lead the textile and food industries into a greener future by developing new sustainable dyeing methods exploiting bacterial genetic resources in an innovation-oriented way using cutting edge technology. The co-operation between the professional textile industry, commercial suppliers of analytical and biotechnological services, and scientists from nine Universities from ten countries addresses urgent needs in the non-academic sector and scientific hotspots in microbiology, bioeconomy and the textile and food industry simultaneously. Bacteria-based pigments, are the common research platform in combination with a broad spectrum of disciplines ranging from microbiology, chemistry, biotechnology, biochemistry, molecular biology, and bioinformatics to textile processing and market research. This will, in the near future, make a range of fully characterised biogenic dyes commercially available to the industry for use in dyeing both conventional and new textiles, allowing the industry to wean itself off petrochemical dyes in an economically viable way. The dyes will potentially find application beyond the textile and food industry, thus allowing many fields to benefit from their low carbon footprint production and their compatibility with human and environmental health. The 12 Doctoral Candidates will obtain multi- sectoral training in the relevant disciplines. In addition, training in research management, communication/presentation, creativity and entrepreneurship will provide key transferable skills for public and private sector employment, thereby maximizing the impact on the research and training on the fellows’ careers. The diversity of dissemination and communication activities guarantees th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'In-situ hybridisation in combination with flow-cytometry as a new tool in water quality control'.

assistant: **Objectives**

Our institute is developing innovative methodologies from basic research in the applied field with special attention on phytoplankton research. The group has leading competence in the physiological characterisation of phytoplankton under different environmental conditions (light, nutrients etc.), even on a single cell basis by means of flow cytometry with subsequent cell sorting. The lack of molecular tools in competence of the group limits its ability to develop new tools for water quality research and basic research in the field of photosynthesis. The combination of molecular and physiological competences will allow to bridge the gap between the key parameters biodiversity of phytoplankton cells and their actual physiological activity. In future, this new knowledge will lead to reliable prediction instruments in ecosystem health.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The “Extended-Personal Reality”: augmented recording and transmission of virtual senses through artificial-IntelligENCE'.

assistant: **Innovation**

Social media has transformed the way we communicate through text, images, and videos. Despite recent technological avenues, virtual reality (VR) has not been incorporated in social platforms, hence limiting the comprehensive sharing of an EXPERIENCE. This project makes real the complex interplay between multisensory perception, emotional responses, past experiences, and perspective of the future also by disentangling the mental representation of self in space and time. The new Extended-Personal Reality technological and scientific paradigms will move Europe to the future generation of extended social interactions by allowing the public at large to i) create their own VR environments as they do photos and videos without the need for technical skills, ii) create virtual simulations eliciting unique psychological, cognitive, neurophysiological, and behavioural responses, iii) automatically generate VR environments from neurophysiological data, iv) easily manipulate VR environments to communicate and elicit specific emotions, v) manipulate perceived reality to effectively treat psychiatric disorders. EXPERIENCE embeds advanced artificial intelligence routines merging information from a person’s Extended-Personal Reality to inform manipulation tools including neuromodulation, multisensory biofeedback (audio, video, haptics), and subjective perception of time-space. EXPERIENCE will produce extremely realistic reproductions of the user's past and may re-administer it by modulating the associated emotional states on demand. Within a large number of research and innovation avenues, EXPERIENCE will prioritise novel diagnosis and treatment of affective disorders commonly associated with altered multisensory perception like depression, anxiety, and eating disorders. A plethora of i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Centre of Excellence in Multifunctional Materials for Industrial and Medical Applications' (NOMATEN), addressing dissemination and exploitation.

assistant: **Impact**

The overall aim of the project is to support the growth of the NOMATEN Centre of Excellence (CoE) in Multifunctional Materials for Industrial and Medical Applications, which was established in Poland in September 2018 and has already secured 37M of funding from the national authorities. The NOMATEN CoE is a partnership between the National Centre for Nuclear Research of Poland and two international partners: the CEA French Alternative Energies and Atomic Energy Commission and VTT Technical Research Centre of Finland Ltd.The NOMATEN team has a long-term experience in materials science research for the front-line nuclear sector and a unique pool of nuclear research infrastructure. They will be used in the CoE to translate cutting-edge knowledge from nuclear sector to the general industry and healthcare.The success and long-term sustainability of the NOMATEN CoE will be based on:- Strategic Research and Innovation Agenda focused on two interdisciplinary topics: (i) novel materials resistant to harsh environments and (ii) novel radiopharmaceuticals for medical applications, which both are aligned with the Smart Specialization of Poland and address strategic priorities of the EU.- Organization structure positioning the CoE as a game changing research entity in Poland with truly international approach and innovative governance and management principles based on the best practices of international partners.- Customer-centric business model making the CoE a focal point for collaboration between the research community, industry and government and ensuring its financial viability.Through generation, application and dissemination of breakthrough research and innovation outputs as well as training the next generation of experts, the NOMATEN CoE will improve Polands scientific excel