RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Collecting, Displaying and Understanding Textiles in Decorative Arts Museums: Comparative Approaches in London and Madrid.' (INTERWOVEN), addressing dissemination and exploitation.

assistant: **Impact**

This project will uncover how collecting practices reflected and informed wider discourses about the study of textiles in Britain and Spain’s national museums and institutes, by tracing specific textiles before and after their acquisition. Whilst fashion and textile studies are now recognised fields of academic research, we still know little about the role of museums in helping to facilitate this change. Cabrera will build on her extensive research to date at the National Museum of Decorative Arts (MNAD), to undertake new comparative studies of UK and Spanish approaches to the study of textiles. This will be achieved via case studies of some of the Victoria and Albert Museum’s (V&A) earliest acquisitions, which have direct connections with Spain. The project will focus on the period 1852-1951, during which many key national museums were born. It will assess the collections and impact of the V&A, which was the model for the MNAD. The V&A will undertake a major redevelopment of its Textile and Fashion Galleries commencing after 2017, which makes re-examination of its historic collections very timely. Cabrera will study textiles held at the V&A from a multidisciplinary perspective, to develop specific object histories and shed light on the formation of European museums and the use of their objects by the creative industries. Case studies will employ approaches from art and design history and engage with new ideas about the transfer of technologies, including the characterisation of raw materials and analysis of fabrics. Key sources will include unpublished archival files, reports and photographs, object labels and the textiles themselves.Cabrera’s training programme would develop her expertise through sustained engagement with museum collections and curatorial and research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Misfolded SOD1 Toxicity in Amyotrophic Lateral Sclerosis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons. The reason for the degeneration of motor neurons in ALS is still unknown. Mitochondria have been implicated as a possible target for toxicity by several studies reporting a range of dysfunctions and the toxic binding of misfolded SOD1 to mitochondrial targets. However, the mechanism by which mutant SOD1 associates with mitochondria specifically from affected tissues is still unknown. Preliminary data show that a cytosolic factor in unaffected tissues is responsible for preventing the accumulation of misfolded SOD1. This factor was identified as the macrophage migration inhibitory factor (MIF). MIF inhibits the association of mutant SOD1 with mitochondria and accumulation of misfolded SOD1.  The hypothesis of this proposal is that MIF is reduced in abundance or inactive as a chaperone within the CNS, leading to increased accumulation of misfolded SOD1 and neurodegeneration. This proposal aims to unambiguously determine how toxicity is caused by misfolded SOD1 accumulation and finally an attempt to rescue these toxic effects in models of ALS will be done. The specific aims are (1) Determination of the tissue specificity of misfolded SOD1 accumulation and mitochondrial association and characterization of MIF activity as a chaperone for misfolded SOD1; (2) Determination of how mitochondrial association of misfolded SOD1 affects mitochondrial function in the spinal cord of mutant SOD1 animals; and (3) Determination of whether increased synthesis or depletion of MIF affects misfolded mutant SOD1 accumulation and pathogenesis in mice. The proposed study has the potential to yield important information about misfolded SOD1 toxicity mech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Discovery of intrinsically disordered sequences conferring desiccation survival' to be submitted under Horizon 2020.

assistant: **Abstract**

Desiccation is a form of stress wherein extremely dry conditions cause intracellular proteins to unfold and aggregate irreversibly, resulting in cell-death. How do cells and organisms survive desiccation is a fundamental question in biology. Cytosolic Abundant Heat Soluble (CAHS) proteins, a family of intrinsically disordered proteins (IDPs) in tardigrades (a phylum of micro-animals), have been shown to be important for their survival during long periods of dryness. Under desiccation condition, CAHS proteins undergo glass-transition and gelation to form vitrified solids that protect intracellular proteins from unfolding and aggregation. However, the features of CAHS proteins that confer protection are unknown. Here, I aim to unravel the sequence determinants of CAHS protein functions, by addressing 3 specific questions:Aim 1: What are the sequence features that promote glass-transition and gelation in CAHS proteins?Aim 2: Can we discover new sequences that can rescue cells from desiccation?Aim 3: What is the sequence-to-function paradigm underlying IDP-mediated desiccation survival? I will (i) perform computational analysis of existing CAHS proteins to extract their sequence features to design a library for adequate sampling of the sequence space; (ii) screen the library with a high-throughput survival-based assay and validate the hits both in vitro and in vivo; (iii) analyse the results with machine learning algorithms to generate characteristic sequence features underlying protective glass-transition. The learned features will be tested by rationally designing and screening a new sequence library for desiccation survival. This project will provide fundamental sequence-level understanding of how IDPs promote stress response, specifically via glass-transition during des
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Unravelling the physics of particle acceleration and feedback in galaxy clusters and the cosmic web'.

assistant: **Innovation**

We will unravel the origin of cosmic magnetic fields, the physics of particle acceleration in dilute plasmas, and the nature of AGN feedback with state-of-the-art radio telescopes. With the enormous gains in sensitivity, survey speed, and resolution of these telescopes – combined with recent breakthroughs that correct for phased-arrays and the Earth’s distorting ionosphere – we can now take the next big step in this field.Cosmic web filaments and galaxy clusters are the Universe’s largest structures. Clusters grow by a sequence of mergers, generating shock waves and turbulence which heat the cluster plasma. In merging clusters, cosmic rays are accelerated to extreme energies, producing Mpc-size diffuse synchrotron emitting sources. However, these acceleration processes are still poorly understood. Clusters are also heated by AGN feedback from radio galaxies, but the total energy input by feedback and its evolution over cosmic time are unknown. We will construct the largest low-frequency sample of galaxy clusters to (1) establish how particles are accelerated in cluster plasmas, (2) quantify how the cosmic ray content scales with cluster mass, (3) determine the importance of AGN fossil plasma in the acceleration processes, (4) characterize current and past episodes of AGN feedback, and (5) determine the evolution of feedback up to the epoch of cluster formation (z=1-2). These results will be essential to understand cluster formation and its associated energy budget.As in clusters, cosmic web accretion shocks should also accelerate particles producing radio emission. Based on the deepest low-frequency images ever produced, we will (5) carry out the first studies of these giant accelerators, opening up a new window on the elusive warm-hot intergalactic medium, where many o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A holistic, scenario-independent, situation-awareness and guidance system for sustaining the Active Evacuation Route for large crowds'.

assistant: **Innovation**

The dynamic capture of situational awareness concerning crowds in specific mass gathering venues and its intelligent enablement into emergency management information systems, using smart communication devices and spaces is critical for achieving rapid, timely guidance and safe evacuation of people out of dangerous areas. Humans could be overwhelmed by fast changes of potentially dangerous incidents occurring at confined environments with mass-gathering. They could fail to make objective decisions to find their way to safety. This condition may lead to mass panic and make emergency management more challenging. In eVACUATE, the intelligent fusion of sensors, geospatial and contextual information, with advanced multi-scale crowd behaviour detection and recognition will be developed. The structured fusion of sensing information with dynamic estimated uncertainties on behaviour predictions will advance eVACUATE crowd dynamic models; and virtual reality simulations of crowds in confined environments.  A service oriented Decision-Support System shall be developed to dynamically distribute on-demand evacuation information to emergency management actors as the crisis unfolds. Decision-makers at the command posts, first responders, front-line stewards and volunteers receive real-time situation aware information of updated evacuation strategies using robust and resilient eVACUATE information and communication infrastructure. Smart spaces of electronic, audio and other mobile devices shall be connected to the integrated system to provide safer evacuation routings for people. The eVACUATE system performance and scalability will be validated in four distinct scenarios involving incidents with large crowd at various venues with the requirements of evacuation time reductions and increa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mediterranean conference of rhizobiology' under Fifth Framework.

assistant: **Concept**

The mediterranean Conference of Photobiology will be the 7th workshop organized by FABAMED - a cooperative research group for biological nitrogen fixation in the mediterranean basin. This Conference will be an attempt to expose the group , and its strategy and results, to other scientists involved in nitrogen fixation and legumes for mediterranean agricultures. Therefore, the overall objective is to improve production and stabilize grain yield of legumes in mediterranean areas , with an emphasis on the mediterranean basin. Indeed, we aim to close the gap between the genetic potential of symbiotic nitrogen fixation (SNF) (estimated to be 70-90% of N-need for the plant depending upon legume species) and the current contribution of SNF (on the average below 30% of N-need in mediterranean areas).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The ‘orphan’ boundary type in plate tectonics:  oceanic transform faults reconstructed' (TRANSFORMERS), addressing dissemination and exploitation.

assistant: **Impact**

The plate tectonic revolution gave birth to three types of plate boundaries; two got most of the interest, i.e., the mid-ocean ridges where new ocean floor is formed and subduction zones where the lithosphere is recycled back into the Earth’s interior. In the oceans, the third type, the “simple” strike-slip conservative plate boundary or oceanic transform fault (OTF), was treated like an orphan in a Charles Dickens novel. However, recent observations challenge plate tectonics, revealing that OTFs show unexpected complex behaviour. The morphology of oceanic transform systems and numerical modelling suggests that OTFs are extensional below their strike-slip faults at the surface. Later in their evolution, before converting from an active fault into an inactive fracture zone at the ridge-transform intersection, OTFs may turn into accretionary features. Yet, how can a strike-slip plate boundary, generating magnitude >7 earthquakes, promote extension forming up to 18 km wide and 7 km deep valleys? Furthermore, a fault zone grading from a strike slip fault into an extensional feature at depth would be a unique geological feature and may control their major seismic slip deficit. TRANSFORMERS will reveal: (i) if OTFs are indeed wrongly classified in plate tectonics and are not conservative plate boundaries, but instead have to be re-classified as features where accretion occurs in two-stages, separated by a period of transform extension, revealing a process fundamentally different from predictions of plate tectonics, suggesting that fracture zones are structurally different from OTFs; (ii) how OTFs operate from top to bottom and why their seismic moment release is too low. The project will require major sea-going efforts, issuing seismological, geodetic and geological surveys o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sustainable Consumer engagement and demand response' under Horizon 2020.

assistant: **Concept**

SENDER will develop the next generation of energy service applications for demand-response, home-automation, -convenience and -security. It puts consumers at the heart of the energy market by engaging them in a co-creation process with other actors from the energy domain during the specification of pro-active DR mechanisms to cater for the consumers’ long-term incentivization. Grid operators are the 2nd group of SENDER core beneficiaries. The project results will increase the efficiency/hosting capacity of distribution networks by improving the quality of load forecasts and providing access to load flexibility, which will allow to improve frequency stability, congestion management and increased RES integration. In addition, monetarization on the flexibility potential will be provided by the participation in balancing/regulatory power markets.SENDER shifts DR from a reactive to a pro-active approach. Consumer data will be collected and processed by means of sensor data from its premises in a cyber-secure way to identify typical consumption patterns, mirror them by digital twins (DT) based on artificial intelligence technologies and aggregate the DTs supply/demand characteristics. The clustering of the consumer DTs will be conducted based on societal science approaches at three demonstration sites.    Allowing interoperability with legacy systems and third-party applications, SENDER envisions business models (BM) that base on the condition that the consumer receives a fair share of the DSOs profit from flexibility use. BMs will focus on the role of the DSO as a facilitator, but also on energy communities/cooperatives as local actors that will manage their members´ flexibility assets. Based on the co-creation process, consumers will also be actively involved into the BM de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Past, present, and future status and mitigation for Cyprus shallow-water reef biodiversity and functioning under global change'.

assistant: **Objectives**

Over the last century and recent decades, the Eastern Mediterranean have warmed faster than most other inhabited regions. In the marine environment, marine heatwaves are known to result in dramatic loss of native species. Further, marine pollutants, like heavy metals and litter, are additional stressors which can be transported from sediment/water column and bio-accumulate in food webs with direct impact on aquatic organisms and humans. Effective management and policymaking are therefore required for the conservation of regional biota. However, Cyprus still lacks capacities and knowledge in the Environment sector, through prioritised in the recently updated Smart Specialisation Strategy for Cyprus. Thus, PUREEF-Y aims at enhancing the progress of the coordinating partner – CMMI, a H2020 Teaming Centre of excellence– towards scientific excellence and policymaking influence by deploying efficient and long-term capacity-building and networking activities with two internationally recognised advanced partners from Israel and Spain. The activities will go beyond the strictly scientific scope and support the mutual development, consolidation, and reinforcement of administrative, dissemination, networking and policy-making competencies.The progress achieved will be demonstrated via a joint research project during which partners will perform baseline assessments of the physicochemical parameters collected from coastal sediments and waters likely to be affected by climate change and ocean acidification; marine pollution levels in key sites around Cyprus, and the health status of key shallow water benthic and planktonic habitats. Over 3 years, PUREEF-Y will result in a long-term linkage between CMMI, UAB and IOLR who share the mission of better understanding past (paleo) and prese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of mitochondria in conserved mechanisms of ageing', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The overall aim of this program is to assess the role of mitochondrial function in ageing and life span control. The strategy that we shall use is to discover mechanisms that show evolutionary conservation between invertebrate and mammalian model systems. We will use a unique matrix of model organisms (yeast, Podospora anserina, Caenorhabditis elegans, Drosophila melanogaster, mouse and rat) and cell culture systems. Specific questions will be experimentally tested. The following age-related issues are addr essed: (i) modulation of mitochondrial reactive oxygen species (ROS) by different means, (ii) relevance of molecular and cellular pathways to maintain a healthy" population of mitochondria, (iii) nature and impact of signalling pathways on mitochondrial a ctivity, (iv) effects of dietary restriction on mitochondrial activity, (v) novel age-related mitochondrial functions. The participating laboratories have a strong commitment for collaborative work and ideally complement each other. Some of the partners ex tensively collaborated in the past or are collaborating presently in the field of research addressed in this IP. They are working with different model organisms and systems, most are well experienced in the field of experimental biogerontology, and they ea ch have a specific expertise in different fields of research ranging from advanced biochemistry, cytology, genetics to molecular biology. This consortium will be in the unique situation to perform competitive research with other programs in the world aimed to identify and characterize mechanisms of ageing that are conserved in most species, hence called 'public' mechanisms of ageing. At the same time, the IP will complement European activities that follow other strategies (e.g., comparing mitochondrial para mete