RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'International Congress on the Radioecology-ecotoxicology of continental and estuarine environments' under Fifth Framework.

assistant: **Concept**

As an international conference on radioecology-ecotoxicology, ECORAD 2001 will provide an up-to-date review of the current state of the art and identify future research priorities. 350 participants as a minimum, from all over the world, are expected to join the modern Congress Centre of Aix en Provence (France) for scientific discussions and delivery of invited/oral/poster contributions. The scientific programrne includes 8 major themes encompassing the behaviour of radionuclides in various environmental systems, ecotoxicology, metrology, as well as ethical perspectives concerning the radiological/chemical risks. All submitted contributions are to be scrutinised by the scientific committee prior acceptance and further publication with standard peer review procedures. An organizing committee is set up to handle all practical issues related to the conference preparation, venue (3 to 7 September, 2001) and proceedings publication.Since the early 40s, radioecology has been faced with the need to evaluate the impact on the environment of radio pollutants released by the use of nuclear energy. It therefore roots from ecology and has focused, in conjunction with ecotoxicology, on the goal to understand the processes of radionuclides transfer and to derive engineering techniques. Within this scope, the concept of sustainable development and the precautionary principle are essential. Radioecology has significantly contributed to both of them, the environment constituting its very field of application. On the threshold of the 21st century, radioecologists need to take stock of the situation and to widen perspectives. This forms the primary objective of the worldwide international congress: ECORAD2001. Based on multidisciplinary discussions and the exchange of up-to-date scientifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-phenotype Analysis of Rare Variants – devELopment of an analysis method and software with implementation to large-scale data to unravel pleiotropic genetic effects behind cardiometabolic traits' to be submitted under Seventh Framework.

assistant: **Abstract**

The obesity rates are rapidly increasing worldwide concomitantly with rising prevalence of chronic diseases, including cardiovascular disease and type 2 diabetes. Individual trait genome-wide association studies of common variants (minor allele frequency, MAF>5%) have highlighted complex genetic relationships between related cardiometabolic phenotypes with an intriguing pattern of associated overlapping DNA sequence variant effects, which does not always follow the epidemiological correlations. Joint analysis of multiple correlated traits: (i) increases power for variant discovery; and (ii) facilitates dissection of the genetic mechanisms underlying multi-phenotype association signals, including evaluation of the evidence for pleiotropy. Multi-phenotype analysis methods for common variants have been proposed, however, with the current focus being in low-frequency and rare variants (MAF<5%/1%), novel method development for identification of such effects is required. The project has three goals:1) To develop a multi-phenotype analysis method for rare variants and to test it on at least 20000 individuals directly available to me. The availability of high-throughput “omics” data, including sequencing data and serum metabolites, adds further challenges to the methods development, e.g. due to genotype uncertainty and hundreds of correlated traits. I will extend the methodological development to the methods for meta-analysis of rare variants, given the need to combine genetic effects across many individual studies;2) To create an efficient publicly available software tool for the developed methods;3) To dissect the genetic architecture behind cardiometabolic phenotypes by conducting a large-scale multi-phenotype meta-analysis of rare variant effects on metabolic traits within
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Toward the first enantioselective synthesis of cytisine' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The applicant, Candice Botuha, joined my group as doctoral student in 1997 following her studies in Paris. During the first 3 semesters here in Geneva she enrolled in courses and fulfilled the requirements of the DES (diplôme d'études supérieure en chimie), a condition that was set for continuing in the Ph.D. program. Candice made enormous progress in this period, gained confidence and started to contribute intellectually to her research. She obtained good marks in her course exams and also in the evaluation of her public presentation of the research results achieved during this period. Her project, the synthesis of new chiral aminophenols and dibenzoazepines and their application as ligands and auxiliaries in organic synthesis encountered on several occasions serious obstacles. Candice is tenacious and she solved most of the problems by herself. This and the good laboratory skills make her a excellent candidate for a Marie Curie fellowship. A strong point, of this candidate is her enthusiasm for preparative chemistry. Admittedly it is also her weak point in that she had to discover more than once that the result of a reaction was not as great as she believed at first. Good training in scientific rigour made these events less and less frequent though and by now she is a skilled and capable scientist. Results from her research work are now coming in at a more rapid rate and her publication record will considerably improve before she finishes her doctorate (late spring 2002). The laboratory that she wishes to join has a different orientation than mine. I insist on this opening to other research fields. The laboratory of Prof. Gallagher enjoys an excellent reputation and Candice Botuha's further training in synthesis will be extremely beneficial to her. European chemical,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Training of IST Innovators to promote and support the exploitation of RTD results by starting new IST business', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Objective is to support IST project exploitation work by conducting 15 training courses on how to write a winning business plan to start new IST business based on results of IST RTD projects. 150 potential IST business opportunities will be selected out of 1500 contacts and invited to 5-day TRAIN-IT courses. Software and expert supported business plan writing is stimulated by lectures, individual coaching, group discussions. High effort is put in internet-supported follow-up of business plan finalisation including annual workshops. A minimum of 150 IST technologists will be trained, resulting in up to 150 completed business plans, ready to be financed and realised. At least 15 new IST companies will be founded, at best 150, a result to be disseminated via website, print media, and IST conference participation. 94 person-months work is organised in 6 workpackages and conducted by a senior European incubator, including subcontracting of 100 expert days to international renowned high-level speakers and coaches.Work description:6 workpackages (WP) are scheduled to realise the objectives of IST Business TRAIN-IT.In WP1 candidates for the offered training courses are identified by various routes and contacts, including special university information days to foster academic IST entrepreneurship.In WP2, selection of candidates, course scheduling, and organisation is carried out, comprising candidate application material exchange and personal interaction, evaluation decision on participation based on selection criteria, as well as organisational support of candidates and subcontracted European expert pool.WP3 concerns the conduction of 15 training courses with true European participation including set-up of course environment and establishment of quality control. Outside experts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Toolbox for assessing and mitigating Climate Change risks and natural hazards threatening cultural heritage' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The TRIQUETRA project aims at creating an evidence-based assessment platform that allows precise risk stratification, and also creates a database of available mitigation measures and strategies, acting as a Decision Support Tool towards efficient risk mitigation and site remediation. The overall approach of Triquetra is based on three distinct steps:1.Risk Identification2.Risk Quantification3.Risk MitigationThis “trifecta” approach (hence the name Triquetra) creates a framework of risk assessment and risk mitigation so as to tackle as many of these risks as possible, in the most efficient way available. This is further analysed in the following sections.


**Keywords:** Climate Models, Decision Support tool, Cultural Heritage sites Database, Digital Twins, Risk Assessment, Climate change Mitigation, Risk stratification, Coastal Heritage sites, Rising sea level risks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A coupled ice sheet - ocean model for calibrated prediction of the future contribution to sea level change from the Pine Island Glacier, Antarctica' (CRAG).

assistant: **Concept**

The potential of marine ice sheets to undergo rapid irreversible retreat has been considered in the glaciological community since the 1970s.  One of the world’s major marine ice sheets, the West Antarctic Ice Sheet (WAIS), contains enough ice to raise global mean sea level by approximately 5m.  However, of immediate relevance to policy makers, the likely rate of WAIS contribution to sea level change on century timescales is not known.This project will couple a state of the art ice sheet model and ocean circulation model.  Ice sheet models are only now reaching sufficient maturity to be applied to predictive studies of marine ice sheet behaviour, partly due to the candidate’s recent advances in modelling the grounding line (the line dividing ice grounded on bedrock from the floating part of the ice sheet).  Ocean models incorporating ice shelf cavity processes are also emerging, and the candidate’s collaborators at the outgoing host are leading development in this area.  Ice sheet – ocean model coupling is essential in predictive studies due to the feedback between evolving ice shelf cavity geometry/grounding line location and ice shelf cavity circulation via sub ice shelf melt rates.The model will be applied to the Pine Island Glacier (PIG), an important outlet glacier draining a portion of the WAIS, which has been studied extensively and is currently thinning at an increasing rate.  The project will use new coupled model and Bayesian calibration techniques to ascertain whether the PIG has crossed a threshold for irreversible retreat and provide a probabilistic quantification of the PIG contribution to sea level change over the next two centuries.The project is novel in the ice sheet - ocean coupling (this will be the first 3D ocean circulation model fully coupled to an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Volume regulation and extracellular signalling by anion channels'.

assistant: **Innovation**

Cells must regulate their volume in response to changes in osmolarity and during cell division, migration, apoptosis, and transepithelial transport. Regulated membrane transport of ions and metabolites creates osmotic gradients that secondarily drive water across the membrane. Organic ‘osmolytes’ such as glutamate also serve in extracellular signalling and volume-regulatory ion transporters are often used for other purposes, putting volume regulation into the context of diverse organismal functions. Research on cell volume regulation stagnated because the identity of a key player, the Volume-Regulated Anion Channel VRAC, remained unknown. Very recently we identified LRRC8 heteromers as VRAC components and discovered that VRACs are a heterogeneous group of channels. Their remarkable ability to transport not only Cl-, but also signalling molecules or drugs, depends on their LRRC8 subunit composition.  This breakthrough now allows us to search for functionally relevant interactors and to dissect the physiological roles of different VRACs using mouse models. Whereas disruption of Lrrc8a abolishes VRAC function, abrogating other Lrrc8 genes (in total five) will change its transport properties. Conditional KO mice will first focus on epithelia which faces large osmolarity changes, on the brain where VRAC-released signalling molecules are supposed to play important roles in physiology and pathology, and on VRAC’s assumed role in vesicle exocytosis. We expect to discover many surprising novel roles of VRACs.Emboldened by our identification of VRAC, we will use genome-wide siRNA screens to identify two other ‘missing’ ion channels, which have been known physiologically for many years and may have widespread roles in signalling and other physiological processes. Once identified,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative decision making for sustainable water management in developing countries' (DIM-SUM) under Sixth Framework.

assistant: **Objectives**

Innovative decision making for sustainable management of water aims at providing tools needed if any integrated and participatory management of water should be carried out. Management refers in this context to its core element, the decision making process (DMP). Focusing on water supply and sanitation (as there the need is paramount), DIM-SUM will carry out one case study in one river basin in each participating partner country, Indonesia, Maharashtra-India, Malaysia and Nepal, in order to evaluate and deve lop these tools. They will on the one hand encompass tools to generate, assess and compare technical scenarios, ranging from argumentative to computational, and fragmented to integrated methods, and on the other, tools to enhance a participatory decision m aking, including information & communication technologies and hybrid methods. The most innovative deliverable of DIM-SUM will be recommendations for a sustainable DMP encompassing an adaptive tool box (comprised of several tools, where the user can se lect those fitting to her/his needs), guidelines and policy recommendations, which will enable local decision makers to carry out an assessment of technical scenarios at an appropriate level of integration and participation. In particular, facing impairing quality and quantity of natural resources, an integrated and participatory DMP becomes vital. Environmental resource efficiency has to be balanced with the risks of technical systems (technical, economic, social, environmental risks), and many other aspe cts. DIM-SUM is motivated by the fact that such exercises are usually carried out in a superficial way only, despite the international call for an integrated water management. Therefore, DIM-SUM will involve a wide range of stakeholders in the project, ran ging from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A drug screen for enhancers of adult neurogenesis in ageing: Drosophila as a new translationally-relevant platform' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Ensuring a healthy lifespan in an increasingly ageing society represents a priority and a challenge for research and innovation. Particularly, irreversible neurodegenerative conditions are becoming hallmarks in the elderly, imposing a severe socioeconomic burden and ultimately threatening quality of life. Promoting adult neurogenesis has the potential to rejuvenate neural circuits restoring cognitive functions. High-throughput models of adult neurogenesis can expedite the identification of mechanisms and compounds for the development of neuro-regenerative therapies. I have evidence for physiologic and drug-induced adult neurogenesis in the genetically conserved and highly tractable model Drosophila melanogaster. Here, I aim to i) characterize adult neurogenesis across Drosophila’s lifespan; ii) identify drugs promoting neurogenesis in ageing in vivo, using the Drosophila olfactory circuit as an experimental platform; iii) test primary drug hits for their potential to promote neurogenesis on hiPSC-NSC in vitro (Host: UGOE, DE; Secondments: MPI-CE, DE; Weizmann, IL; DZNE, DE). Next, during a Non-academic placement in a translational drug discovery company, I aim to profile prioritized hits promoting neuronal regeneration (LDC, DE). My unique background in chemical engineering and biosciences will be pivotal to successfully complete this project. By leveraging state-of-the-art tools and support from experts in the field, Droscreeneuro represents an innovative, ambitious, and translationally-relevant approach towards the development of regenerative therapies aimed at counteracting age-related neurodegenerative diseases. Dissemination of results between specialized and general audiences will make science open to all. Ultimately, exposure to high-quality training in the acade
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'KINETICfinder: A disruptive method to determine kinetic profiles in drug discoveries' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Bringing Bringing a new drug to the market costs 2,600 M€ and it takes 12 years. In addition, around 80% of drugs under research do not reach clinical trials (due to toxicity or lack of efficacy). ENZYMLOGIC was created with the aim of being a company in the niche of kinetic analysis. They have developed KINETICfinder: an experimental, robust, accurate and reproducible methodology that provides drug kinetic analyses in a massive way and at affordable cost, so it is possible to utilise it in early research stages, when thousands of drugs are involved. ENZYMLOGIC has been focused on providing auxiliar external analysis having pharmaceutical companies as customers. Nowadays, there are no comparable technologies capables of generating this amount of information with this level of processivity (number of drugs analysed at the same time). Currently, this analysis is extremely slow and costly, thus it is carried out in the final stages of the research, with just a small number of drugs. Otherwise, the number of different drugs they can analyse is 10 times higher and 10 times faster than other kinetic analysis (processivity).  KINETICfinder can reduce the time and cost by 50% from the research phase of a new drug to the market phase. KINETICfinder already makes it possible to analyse 30 kinase targets (involved in cancer), and the next step is to work with GPCRs (neurodegenerative disorders, inflammation, pain, cardiovascular diseases and diabetes). 40% of the existing drugs are aimed at GPCRs. ENZYMLOGIC has obtained several prizes recognizing innovation and potential growth. The objective in phase I will be the validation of the use of KINETICfinder for working with GPCRs having as a base the previous work performed with kinases. To achieve this, the associated tasks shall be