RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'DNA-TRAP – Delivery of Nucleic Acid-Based Therapeutics for the TReatment of Antibiotic-Resistant Pathogens' (DNA-TRAP).

assistant: **Concept**

Antimicrobial agents, such as antibiotics, have dramatically reduced the number of deaths from infectious diseases over the last 70 years. However, through overuse and misuse of these agents, many micro-organisms have developed antimicrobial resistance. Oligonucleotide therapeutics have the potential to become the new class of antibacterials capable of treating a broad range of infections. By acting on novel targets, they circumvent current resistance mechanisms and with judicious use, can suppress the rise of future resistance.DNA-TRAP will build on a platform technology that uses proprietary nucleic acid-based Transcription Factor Decoys (TFDs) that act on novel genomic targets by capturing key regulatory proteins to block essential bacterial genes and defeat infection. Taking forward newly emerging insights and expertise that exists within each of the partners and through the mutual secondment of researchers, the project aims to develop a new class of nanoparticulate antibacterials capable of meeting the clinical challenge of drug-resistant infections such as Clostridium difficile and Pseudomonas aeruginosa.DNA-TRAP will establish a lasting, international partnership for transfer of knowledge between Industry and Academia in the field of nanomedicine. Exchange of knowledge and expertise between the partners is key to establishing the fundamental properties of nanostructured drug delivery systems to treat bacterial infections and through this, provide the basis for building a manufacturing platform to advance the experimental therapeutic into clinical trials.17 researchers in the field of drug development and delivery from 2 commercial (SME) and 2 non-commercial partners across 2 member states, will have the opportunity to share and acquire new complementary and multi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stabilisation of iron gall ink containing paper' (INKCOR) targeting Fifth Framework.

assistant: **Abstract**

The world's libraries, archive and museums are faced with the immense problem of preserving countless documents, endangered by the corrosive properties of their on gall ink. A non-aqueous conservation method, enabling massive approach, treatment of bound volumes and water sensitive items is desperately searched for. This project aims at development of a new non-aqueous paper stabilisation treatment based on a combined action of alkali and antioxidants. The effect of preventive antioxidants as well as chain-breaking ones will be studied using state-of-the-art experimental and analytical techniques. In addition to establishing better conservation practices, enabling preservation and undisturbed access to the numerous artefacts threatened by ink corrosion, the project will substantially increase present knowledge of ink compositions, oxidation mechanisms as well as offer new analytical methodology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Extragalactic Interstellar Medium - Measuring Dust Extinction using Gravitational Lensing' to be submitted under Seventh Framework.

assistant: **Abstract**

One of the most intriguing recent results in the physical sciences, has been the growing body of evidence that 70% of the energy content in the universe comes from an unknown energy field (‘dark energy’).  One of the most promising methods for quantifying dark energy, is using SNe Ia as standard candles.  However, a key issue in SN Ia studies is whether the results are biased by cosmic dust.  The interstellar medium (ISM) of galaxies causes light passing through to be partially extinguished.  The extinction depends on wavelength, and is directly related to the dust composition of the ISM.  While the extinction from the ISM has been mapped extensively in the Milky Way, little is known about the extinction properties of more distant galaxies.  Therefore, when correcting for dust, typical Milky Way dust extinction is assumed, even though dust properties in galaxies are expected to depend on redshift.  This proposal aims at measuring extinction curves of distant galaxies using gravitationally lensed multiply imaged background sources.  The proposal is in part based on proven methods, and in part based on a new technique, extending the method to a larger sample. The importance of this work is not limited to SNe Ia surveys, but impacts any astrophysical probe, as incorrect assumption on the dust properties can cause a non-negligible bias in derived quantities.  In addition, the measured evolution of dust with redshift will give insight into galaxy formation.  The fellowship provides the fellow with an excellent opportunity to perform independent research at cutting edge institutions (Princeton and NBI), and collaborate with experts in the field.  This gives the fellow an opportunity to become an independent researcher with expertise in the ISM. The fellowship will be mutually
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Variability and Robustness in Bio-molecular systems' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Cells process information using biochemical networks of interacting proteins and genes. We wish to understand the principles that guide the design of such networks. In particular, we are interested in the interplay between variability, inherent to biological systems, and the precision of cellular computing. To better understand this interplay, we will: (1) Characterize the extent of gene expression variability and define its genetic determinants, (2) Reveal how variability is buffered and (3) Describe instances where variability (or 'noise') is an integral part of cellular computation. The study will be conducted in the multidisciplinary atmosphere of our lab, by students trained in physics, computer science, chemistry and biology. Specific issues include: 1. Gene expression variability: we will focus on the influence of chromatin structure on gene expression variability, as suggested by our bioinformatics analysis.  2. Robustness and scaling in embryonic patterning: We will study the means by which fluctuations are buffered during the development of multicellular organisms. We will focus on the robustness of morphogen gradients to protein levels, and on the ability to maintain proportionate pattern in tissues of different size. 3. Noise-driven transitions in a fluctuating environment: Our preliminary results suggest that noise plays an integral part in phosphate homeostasis in S. cerevisiae. We will characterize the role of noise in this system and study its evolutionary implications.  Together, our study will shed light on one we believe to be the fundamental challenge of biological information processing: ensuring a reliable and reproducible function in the highly variable biological environment. Our study will furthermore define novel multidisciplinary, system-level
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'South Marmara Hydrogen Shore'.

assistant: **Innovation**

The region of South Marmara is ideally placed, geographically, economically, and politically to take up the challenge of developing and implementing a hydrogen valley in 2023 and help to build towards the national Turkish goal to be carbon free by 2053. South Marmara is situated between the largest metropolitan areas of Türkiye (Istanbul to the north, Izmir to the southwest and Bursa to the east. It is bordered by the Aegean Sea to the west and the Sea of Marmara to the north which gives it unlimited access to water.The South Marmara region has set a clear vision to reach a carbon-neutral economy by 2053 by phasing-out fossil-fuel utilization in all sectors and green hydrogen will play a critical role in this path.The HYSouthMarmara project is the first step of this vision and it will;- Create a detailed roadmap which sets out recommendations up to 2035 and beyond in terms of establishing a regional hydrogen economy- Design, deploy and install a Polymer Electrolyte Membrane (PEM) electrolyser with a minimum 4MW of power to reach annual hydrogen production of 500 tonnes- Develop and implement a digital twin of the hydrogen production system that will create the flexibility for renewable energy usage and efficient production of green hydrogen- Create the South Marmara Hydrogen Backbone by determining the infrastructure requirements for the storage, transport and deployment of the green hydrogen- Demonstrate the uptake and replacement of grey hydrogen with green hydrogen in two industries, hydrogen peroxide production and glass manufacturing- Conceive and build a kiln to use hydrogen as a fuel in energy-intensive ceramic industrial processes- Develop Sodium Borohydride plant and use it as a basis for a power supply- Explore and create new markets for the use of green hydro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Single Molecule Nuclear Magnetic Resonance Microscopy for Complex Spin Systems', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Nanotechnology is emerging as a key area to address global challenges in health, energy, environment and information technologies. However, we are still investigating most nanomaterials with bulk techniques, averaging over large samples, instead of looking at one single nanostructure with true nanoscale sensors. Particularly, Nuclear Magnetic Resonance (NMR) as our workhorse for bio/chemical synthesis and medical imaging is inherently limited to bulk samples. The most fundamental challenge, to turn NMR from an ensemble-measurement technique (Commercial NMRs typically have a sensitivity of billions of molecules) into a nanocale technique remains unsolved. In this project we will overcome this challenge by reaching single molecule sensitivity, thus converting NMR into an imaging technique thanks to the exploitation of the unparalleled atomic resolution of the scanning probe microscopy (SPM) technology. This breakthrough will be based on resonant, high frequency, electro-magnetic excitation and readout including important advances in GHz technology. We will use the capabilities of the novel technology to demonstrate detection of single spin NMR and to test the limits of our understanding of nuclear-electron interactions, probing the physics of molecular nanoobjects, 1D carbon nanoribbons with delocalized coherent states, and 2D atomically-thin magnetic materials.  This novel technology will not only open up new fundamental scientific insights but should also have a strong impact in the markets of NMR and SPM. In this context, the project will be a keystone, demonstrating the novel platform conceived as a versatile upgrade for commercially-available SPMs, that can routinely operate in various environments (vacuum, ambient, liquid) with a variety of molecules and materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'FISHERIES INDEPENDENT SURVEY BASED OPERATIONAL ASSESSMENT TOOLS' (FISBOAT).

assistant: **Innovation**

Current fish stock assessment is based primarily on fisheries data (catches/landings) and models of population demography (cohort analysis). Collapse of important fish stocks in the past (e.g. cod in Canada) have revealed that fisheries based demographic indices suffer from a number of limitations. Probably the most serious limitation is that the indication of population collapse is only perceived very late with such indices, in comparison with other biological indices.The purpose of this project is to develop fish stock assessment tools based on survey data only and evaluate how these perform in producing advice within defined management procedures. The project spans several disciplines (i.e., population biology, survey methods, stock assessment, management), with the objectives of (1) producing a comprehensive diagnostic of population status using survey-based population demography and biological indices and (2) evaluate its performance in a management context.A variety of methods is proposed to obtain direct estimates (and associated errors) of population abundance, mortality, spatial occupation and maturity at age. Direct demographic estimates feed assessment population models to deliver model-based estimates of abundance, survey catchability, natural and fishing mortality. Different categories of population assessment models are developed for to different biological situations. The simplest models track the dynamics in total abundance while others are age or length structured. The assessment procedure is evaluated by simulation testing using a framework containing a population dynamics model, an observation model, an assessment model and an harvest rule model. The ability of the assessment procedure to capture changes in population biology and survey catchability i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EFFICIENT COMPACT MODULAR THERMAL ENERGY STORAGE SYSTEM' (ECHO).

assistant: **Concept**

The project’s goal is to develop and demonstrate novel modular, compact, high performances and Plug&Play thermal energy storage (TES) solutions for heating, cooling and hot tap water production. The new concept of TES proposed in the project will provide electricity load shifting with meaningful peak shaving of the thermal and electric load demands. Furthermore, the exploitation of renewable sources will be a key point of the new TES device considering at the same time the cost-effective results in terms of energy, costs and sustainability of the system.The project will provide a TES system able to store energy for heating and cooling in building applications for a period of at least four weeks. The novel TES system will be based on a closed-loop TCM reactor insulated by PCM and equipped with an ice storage, again integrated with PCM, for high cooling energy demand. The thermodynamic cycle has been designed to benefit from a further PCM thermal buffer tank, breaking through the closed-loop concept by compensating the energy for humidification with its latent heat. An advanced heat pump will be finally dedicated to the power conversion during the thermal charging process of reactor and PCMs storages, increasing the overall performance.A dedicated control system will be developed to operate the TES according to the energy production and the end-users’ requirements, adapting to the conditions of use according to the type of air conditioning system and the particular demand for domestic hot water.The TES solution will be adaptable to all the different possible European scenarios, in terms of energy policy and end-users’ requirements. It will be designed to be used both as integrated into the building heating system and in the smart electricity grid, or in buildings not conn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards Open Societies? Trends, Variations and Driving Forces of Intergenerational Social Mobility in Europe over the Past Three Centuries' (TOWARDSOPENSOCIETIES), addressing dissemination and exploitation.

assistant: **Impact**

Have our societies become more meritocratic, in the sense of more  open , more  fluid ? And if so, why, since when, and how quickly? We answer these points by studying intergenerational social mobility during the past 300 years. More precisely, we compare the social class positions of children with those of their parents in various epochs, countries, and within countries in various regions, and relate these associations to the institutional contexts of the societies and to notable characteristics of the individuals in question.Has there been a trend towards more intergenerational social mobility in all or some parts of Europe? Have levels of mobility converged? If so, where and when did those trends start? What were the determinants of social mobility in the various regions and historical periods? Which institutions have historically furthered and which have hampered social mobility between the generations?This research project is grounded in the belief that social mobility patterns differ significantly and meaningfully over time and between regions. This has been masked by the fact that even the most brilliant contemporary studies of social mobility (a) have only the short time span surveys allow, (b) can thus only partially consider institutional variation, and (c) assume invariance or linear trends. Historical variance often appears either absent or meaningless.The long time horizon of this research programme in combination with measured institutional variation at the regional level in historical societies will allow us to (a) capture slow changes, (b) test better for changes that are non-linear and do not appear in all regions at the same time, and (c) connect observed changes to institutional determinants.We will do this using a unique historical database of 3.7 mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cooperative Acceptor Ligands for Catalysis with Earth-Abundant Metals' (CALCEAM) under Horizon 2020.

assistant: **Objectives**

Homogeneous catalysis is of prime importance for the selective synthesis of high added value chemicals. Many of the currently available catalysts rely on noble metals (Ru, Os, Rh, Ir, Pd, Pt), which suffer from a high toxicity and environmental impact in addition to their high cost, calling for the development of new systems based on first-row transition metals (Mn, Fe, Co, Ni, Cu). The historical paradigm for catalyst design, i.e. one or more donor ligands giving electron density to stabilize a metal center and tune its reactivity, is currently being challenged by the development of acceptor ligands that mostly withdraw electron density from the metal center upon binding. In the last decade, such ligands – mostly based on  boron and heavier main-group elements – have evolved from a structural curiosity to a powerful tool in designing new reactive units for homogeneous catalysis. I will develop a novel class of ligands that use C=E (E=O, S, NR) multiple bonds anchored in close proximity to the metal by phosphine tethers. The electrophilic C=E multiple bond is designed to act as an acceptor moiety that adapts its binding mode to the electronic structure of reactive intermediates with the unique additional possibility of involving the lone pairs on heteroelement E in cooperative reactivity. Building on preliminary results showing that a C=O bond can function as a hemilabile ligand in a catalytic cycle, I will undertake a systematic, experimental and theoretical investigation of the structure and reactivity of M–C–E three membered rings formed by side-on coordination of C=E bonds to a first-row metal. Their ability to facilitate multi-electron transformations (oxidative addition, atom/group transfer reactions) will be investigated. In particular, hemilability of the C=E bo