RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular mechanisms and cellular consequences of enterovirus persistence in cardiomyocytes' (CARDIOVIR), addressing dissemination and exploitation.

assistant: **Impact**

Enteroviruses (EV) are small naked single-stranded positive RNA viruses of approximately 7,400 nucleotides. Their genome is flanked on the 5' end by a non-coding region (NCR), which is crucial for the initiation of the replication and translation of the viral genome. Enteroviruses are common human pathogens, transmitted through fecal-oral and respiratory routes. Although the majority of EV infections remain asymptomatic, these viruses, especially group B coxsackieviruses (CVB), are considered to be a common cause of acute myocarditis in children and young adults, a disease which is a precursor to 10-20% of chronic myocarditis cases as well as dilated cardiomyopathy (DCM, prevalence = 7 cases / 100,000, second leading cause of heart transplantation worldwide after ischemic heart disease). However, the viral molecular mechanisms involved in the progression of acute myocarditis to chronic myocarditis and subsequently to DCM are currently poorly understood, thereby limiting the development of new specific therapeutic strategies. In 2011, our research team (EA-4684 CardioVir/FRS CAP-santé, University of Reims Champagne-Ardenne) reported CVB strains presenting with genomic 5’ terminal deletions ranging in size from 15 to 35 nucleotides in explanted heart tissue collected from patients suffering from idiopathic DCM. These deletions could explain how the virus can persist in the heart long after the acute infection leading to the development of chronic cardiomyopathies. The objectives of this proposal are to determine the mechanisms by which deleted EV ensure the translation and replication of their genomes and to assess the effects of persistent infection on the structures and functions of infected cardiac myocytes. A better understanding of the molecular mechanisms implicated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Investigation of mathematical models for thin-film flows'.

assistant: **Objectives**

This research project will bring together Dr Roman Taranets, an outstanding young researcher at the Ukrainian National Academy of Sciences, and Professor John King, a leading expert in the theory of thin film flows at Nottingham University, UK. The research will be focussed on flows of thin liquid and polymer films. The combination of Dr Taranets’ background in research methods for the rigorous investigation of the qualitative properties of solutions to nonlinear partial differential equations and the host’s expertise in formal asymptotic methods and contacts with a range of industry-driven applications will be an ideal basis for a successful fellowship. During the research project, we will • study exact asymptotic behaviour travelling wave solutions for the thin film equation with non-zero contact angles; • show the existence of a generalized solution for multi-dimensional coating flow models without surfactant and to investigate the behaviour of support of these solutions; • investigate the asymptotic behaviour of generalized solutions for multi-dimensional coating flows with surfactant; • put in place additional research programmes involving novel areas of application and employing innovative combinations of mathematical techniques. Benefits of this transfer of knowledge will include the implementation of the collaborative research programmes above, the initial training of both early-career researchers in the UK and Dr Taranets in complementary mathematical approaches and the application of these unusual combinations of skills to a host of applications that are representative of the many fields in which high-order parabolic systems are now playing a central role. Moreover, ongoing collaborations between the Ukrainian and UK groups will provide a conduit for the conti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Polariton networks: from honeycomb lattices to artificial gauge fields'.

assistant: **Concept**

Boson gases confined in lattices present fundamental properties which strongly depart from their 3D counterparts. A notorious example is the honeycomb lattice, whose geometry results in massless Dirac-like states. By engineering the phase picked by the particles when tunneling from site to site, lattices also allow for the generation of artificial gauge fields. They result in very strong effective magnetic fields, opening the way to the observation of new quantum Hall regimes in neutral particles. In this context, polaritons appear as an excellent platform for the study of boson fluid effects in confined geometries. Polaritons are two-dimensional half-light/half-matter quasi-particles arising from the strong coupling between quantum well excitons and photons confined in a semiconductor microcavity. They are fully accessible by optical means and present strong non-linear properties. In this project, I will fabricate polariton microsstructures to study mesoscopic physics in 2D lattics.I will start by studying the non-linear Josephson dynamics in coupled micropillars, and engineer a double tunneling structure showing single polariton blockade. I will then fabricate a graphene-like honeycomb lattice, where I will study transport phenomena such as anomalous (Klein) tunneling and antilocalisation in the presence of disorder, phenomena originating from the Dirac-cone characteristic of honeycomb lattices. In the high density regime, I will investigate non-linear effects, and address the question of superfluidity of massless Dirac particles.Finally, I will undertake the realization of artificial gauge fields for polaritons. I will adapt to the polariton case a recent theoretical proposal to create artificial gauges in photons using coupled microdisks. Our results will have stron
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A combined pox-virus/lentiviral vector system to treat HIV infection. Immunization and direct in vivo gene transfer in T lymphocytes.' to be submitted under Sixth Framework.

assistant: **Abstract**

HIV infection in humans induces chronic changes in the phenotype and function of CD4, CD8 and Dendritic Cells, which are only partly restored after the initiation of HAART. In order to alleviate the permanent dependency on HAART, alternative therapies whos e goal is to restore normal immune functions must be developed. Attenuated pox-viruses are currently under evaluation as prophylactic or therapeutic vaccines against AIDS. Development of a successful pox-virus vaccine is still a significant challenge due t o the nature of HIV-1 infection, despite the fact that pox-virus vector vaccines can induce potent immune response and have been developed for large scale vaccine production using GMP conditions. In this project, we shall exploit this knowledge and employ high level bioengineering to create a pox-virus vector that encodes, in addition to some HIV-1 proteins, a fully functional lentiviral vector genome delivering heterologous genes with HIV inhibitory capacity. Cells infected with Modified Vaccinia Ankara (M VA) will simultaneously be converted into packaging cells capable of releasing transducing particles and cells expressing HIV-1 proteins for the stimulation of antigen specific cells. Consequently, the Pox-Gene vector will serve a dual role as a therapeuti c vaccine and as in vivo gene therapy. The transducing particles released in vivo will protect naïve, memory and activated T cells (including HIV antigen-specific T cells) from HIV infection. Over the course of this project we shall demonstrate the Pox-Gen e efficiency for transduction of T cells in vitro and in vivo using marker genes. Finally after proof of concept has been obtained in mice we will perform a small pilot study in SHIV infected macaque. This approach should elicit significant improvement in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Waste in social environment'.

assistant: **Innovation**

I.A.R. of Aachen University, in co-operation with an extensive network of supporting universities and experts, is one of the leading expert waste management institutes with long experience in organising top- level training courses. This programme of waste management is looking at new sustainable technologies, barriers to uptake, public information campaign, transfer of technologies and expertise, best practices and sustainable management of waste. The 6 courses are divided into 3 phases. The 1st phase will teach the basics of waste management and key technologies giving them access to innovative key European technologies. To solidify this, there is a strong element of practical hands-on and hands-in where the researchers will get direct experience of the basics of the 3 Rs (Recycle, reuse and reduce). 2nd Phase will look at problem case studies where this knowledge learnt in the first phase can be applied to real life scenarios. The 3rd Phase will show 2 examples of integrated waste management complexes both of which are the most advanced in their fields. Experience has shown that even though waste technologies are being developed and improved, the problems of waste are not being solved at the same pace. In many cases, the inter-linking factors of technology, people, social environment, culture and legislation are not considered adequately when designing or implementing a waste management plan.The only way to initiate change is to start effective training with an integrated environmental approach learning by experience focusing on good practices targeted at top researchers who will become those decision makers, company employees, government official and technicians. Different European locations with lectures from leading academics, waste managers and industrialists wher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Internal Dynamics and Magnetic field generation in rocky bodies: planets and large moons in the solar system', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Earth is a peculiar planet in the solar system: it hosts life and possesses a very active interior. However, it is not the only rocky body to present evidence of internal dynamics: all the rocky planets - except Venus - and some moons have been proved to generate or to have generated a magnetic field. Recent space missions have improved our knowledge of the evolution of these magnetic fields, and direct constraints on the internal structure of some rocky planets are expected in the very next few years. New hypotheses emerged recently to explain the early times of the Earth’s magnetic field, when no thermo-chemical convection could power the geodynamo, giving us new perspectives on Earth’s history. By combining advances in both Earth and planetary sciences, InDyMag aims to better understand the internal dynamics of the Earth and other rocky bodies in our solar system. It will investigate the generation and long-term evolution of their magnetic fields with Earth as a reference, and compare it Mercury, Venus, and Mars, and the Earth's Moon and Ganymede. The fellow, expert in geodynamics and modeling, will develop a model for the time evolution of temperature and composition profiles in metallic cores, exploring a large range of parameters including planet's size, composition and formation history. The crystallization regimes and the initial profiles will be investigated in detail, exploring the full range of dynamics possible in an iron core. Thanks to the expertise of the researchers at the host LPG on space missions and magnetic field measurements, InDyMag will combine observations to geodynamical models to constrain the physical parameters of planetary cores. InDyMag will unravel what is universal in planetary magnetic fields, and what is planet-specific. Its result
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mass Spectrometry-Based Chemoproteomic Profiling of Nav1.7, a Voltage-Gated Sodium Channel' (MaSCheNav), addressing dissemination and exploitation.

assistant: **Impact**

Chronic pain represents a major unmet medical need which has been linked to changes in voltage-gated sodium channels (VGSCs). These channels are transmembrane protein-complexes with a key-role in signal transmission in excitable cells, such as neurons, and allow the flux of Na+ ions through the cellular membrane in response to specific stimuli, thus controlling the generation and propagation of action potentials. Nine VGSC subtypes are known to be expressed in different cell types, and among them subtype Nav1.7 is of extreme interest since it is involved in nociceptive processing (pain-sensing) in the peripheral nervous system. Remarkably, patients suffering from congenital indifference to pain syndrome, which derives from loss-of-function mutations of the gene encoding for Nav1.7, have a dramatically reduced ability to perceive painful stimuli, but are otherwise perfectly healthy. Therefore, Nav1.7 has been recognized as an exciting target for pharmacological treatments of pain. However, detailed structural and functional information is lacking, and its attainment represents a fundamental step in the challenging task of finding Nav subtype-selective modulators. Thus, the main focus of my project is to study ligand-binding events with known modulators, thereby paving the way to the design of safe and selective inhibitors. I will develop, by solid phase peptide synthesis, a chemical probe specifically designed to isolate Nav1.7, using a tandem photoaffinity labeling-bioorthogonal conjugation approach. This probe will be applied in model cell lines expressing the channel, in order to study their binding interaction through mass spectrometry-based chemoproteomics. Once these chemical tools are established and validated in the model system, I will translate them to patient-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Physics is Fun' to be submitted under Sixth Framework.

assistant: **Abstract**

The programme 'Physics is Fun' aims to bring closer to the Society a difficult (and often dull) subject as Physics, using modern tools and visual didactical methods ('toys'). It enters into initiatives of 'World Year of Physics, 2005'.The initiative is based on previous experience in Italy and in Poland, with numerous editions at regional and subsequently at national level. With present action we plan to bring these exhibitions to the European level.The outcome of the programme will be: 3 exhibitions with panels and real-objects, open to wide public, 1° at Ecole Centrale Paris, (November 2005) 2° at GIREP (International Research Group on Physics Teaching) Lubljana in Slovenia (September 2005); 3° XXXIX National Congress in Physics in Warsaw, Poland, September 2005 1 CD-ROM on 'Physics and Toys'; (in 4 language versions) and 1 CD-ROM on 'On the Track of Modern Physics' (in 3 language versions) and 1 thematic issue of 'Foton' Journal entitled 'Physics is Fun' (in Poland).The primary objective is to present Physics as easy and fun, making it understandable and attractive for average-level public. The secondary objective is to rise the social consciousness of Modern Physics, by presenting both achievements and open problems; in pure Physics and Applied Sciences, in non-standard ways.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An advanced 3D simulator to generate 3D-personalized tissue and organ models for diagnosis, planning and pre-treatment of medical vascular interventions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

VALIDA INNOVATION S.L. emerged with the goal of developing a new 3D simulator that improves the diagnosis, planning and pre-treatment interventions and therefore, improving patient safety and reduction of associated cost to medical errors. This simulator provides a high value in 3D organ models due to its physical mechanical identical to the real ones are able to replicate the patient´s own organ and pathology. The main objective of MedicalPhant project is to develop and commercialized, based on MRI, ECO and CAT studies on patients, a cardiovascular personalized model of external and internal vasculature that allows simulating complex clinical situations due to cardiovascular diseases are the main cause of death globally. Currently, the simulator prototype has a technology level TRL6 and it has been validated in a relevant environment through its implementation in a real case study of cardiovascular surgery providing diagnostic capacity before intervention and patient´s safety after intervention. However, the company needs to work in the implementation of the business model, in the industrial adaptation of our prototype and, in achieving the certification of our 3D simulator to be commercialized. The key stakeholders involved in this project will be hospitals to carry out clinical trials, private, public hospitals and universities to use our technology, specialized organizations in charge of certificating our device to obtain the CE Mark and FDA, key opinion leaders to get a better penetration on the market and patient associations which will contribute to the dissemination of our innovative 3D printing technology in the cardiovascular market. The initial plan to commercialize the MedicalPhant consists in the combination of own production with a partner plus licensing o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Governing Nanotechnologies through societal engagement' (GoNano).

assistant: **Innovation**

GoNano has as its main objective to improve the responsiveness of research & innovation processes to public values and concerns. The project builds on previous projects in public engagement and new technologies to develop a pilot project in each of the nanotechnology research areas ‘Health’, ‘Energy’ and ‘Food’. The pilot projects will engage citizens with researchers, professional users, civil society organisations, industry, and policy makers in a continuous process of deliberative workshops and online consultations to co-create concrete suggestions for future nanotechnologies. GoNano will build a broad community of ‘change agents’ for integrating an ‘RRI way’ of working on research and innovation, and it will develop and disseminate an RRI business case to align public values, needs and concerns with industry’ for profit ambition. GoNano builds on the basic assumption that several types of knowledge are needed to define sustainability, acceptability, and desirability of nanotechnologies, as well as the belief that online and offline engagement activities must be combined with a creative approach to dissemination and communication to ensure continued interest and engagement in the debate on nanotechnologies future application. GoNano believes that its interactive and open approach to: developing the nanotechnology product suggestion; writing policy recommendation and building an RRI business case; informing and educating about nanotechnology as well as the value of co-creation will build trust and mutual understanding among all the stakeholders, including public and private stakeholders and citizens.


**Keywords:** citizen engagement,  stakeholder engagement, governance, policy advice, nanotechnologies, Responsible Research and Innovation, research and industry netwo