RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Replacing the Animal Source of Viscous Fluids Used in Cataract Surgery with the Okra Plant Source' (OkraVision).

assistant: **Concept**

Eye cataracts, leading to the loss of vision present a major problem for the aging population. This is currently cured by surgical procedure which requires a viscoelastic High Molecular Weight (HMW) product of Ophthalmic Viscosurgical Device to fill the space in the eye created during the surgery and to protect the healthy endothelial cells. Due to the growing elderly population, this market segment is expected to grow at least 7% per year and will reach €80 Mn in the EU and €240 Mn worldwide by 2014. The market need for (HMW) products is currently served by Hyaluronic acid (HA) and cheaper alternatives derived from cellulose with properties inferior to HA. The manufacturers have currently to rely on few suppliers of the high-quality raw materials i.e. roosters bred on a special diet. The animal nature of the raw materials makes the SMEs particularly vulnerable in light of a bird flu outbreak, creating the threat of losing up to an entire year supply of the raw material with a single outbreak in the region. In addition, using raw materials of animal origin in humans requires compliance with existing EU regulations (EC 1774/2002 and Directive 90/426/EEC, and also Directive 86/609/EEC, 3 R’s Declaration, and REACH). Hence EU SMEs such as ourselves realize that we should switch to a non-animal source of HMW substance, as a substitute to rooster combs originating HA. The main objective of the OkraVision project is to substitute animal based production of HMW HA with a cheaper and non-animal HMW substance: Rhamnopyranose–Galactopyranose–Galactopyranosyluronic Acid (RGGA) from the okra plant (fruit) with the targeted chain length of 800-1000 units, MW of 5-6 MDa, and the targeted zero shear viscosity of 1-3 Mn mPas for 1-2.5% aqueous solution. This will be done by developing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Automated extraction of image object metadata'.

assistant: **Concept**

Axiom addresses scientific and technical challenges in the analysis, organisation, searching and manipulation of digital image streams for the digital cinema industry. Film or cinema is a driving force for the entertainment industry, and the movie chain is now going digital, from origination through distribution to display, producing a massive increase in data volumes and work methods. Automated content-based access to visual media is now a major field of research activity. The notion is to allow access to media in the same way that Google allows access to text, without the need for keywords.Image and video processing algorithms are being developed that attempt to 'understand' media in some sense and so suggest media snippets in response to user queries. The electronic media industry has yet to implement these ideas, because the research community has focussed on the wrong questions. AXIOM plans to solve the problem by bringing together an academic partner, Trinity College Dublin (TCD) Sigmedia Group, which is expert in video processing and content based access, with an industrial partner (The Foundry) specialising in the development of film post-production software. The purpose of this collaboration is to research techniques for content analysis and the use of content-based information to direct low level image and video processing tools for creative postproduction.The three-year project involves exchanges, in both directions, of a total of four experienced and two very experienced Fellows in a structured programme of training and research in algorithmic methods, GPU programming, and software plug-in development. It grows from four years of work between the partners and is designed to lead to a long-term structured collaboration. The outcomes will include new algorithm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Platelet diagnostics'.

assistant: **Objectives**

Individuals with low platelet counts have an increased risk of bleeding, which, when it occurs in the brain, can cause disability or death. The risk of such bleeding is reduced by platelet transfusion. In Europe, 1.4 million platelet concentrates are transfused each year. A low platelet count can result from failure to produce platelets, as occurs in cancer patients, or from their destruction by antibodies, which occurs in 1 in 1000 newborns because of a difference in platelet type between mother and baby, and can result in brain damage with an incidence of up to 1 in 5,000 births and a life health care cost of 570,000 euro per child. Certain platelet antibodies can also reduce the chance of a successful kidney transplant. Screening of pregnant women for prevention of Rhesus babies, the red cell equivalent of the platelet destruction in babies, is often mandatory, but the complexity of platelet tests means that antenatal screening is currently unaffordable. We propose to develop simple, affordable platelet diagnostics with the aims of reducing the incidence of cerebral bleeds, and improving kidney transplants by improved matching between donor and patient.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment'.

assistant: **Concept**

The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g., tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g., tissue extraction and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'LiquidEff: Algebraic Foundations for Liquid Effects' (LiquidEff) under Horizon 2020.

assistant: **Objectives**

The goal of the LiquidEff project is to significantly advance the state of the art of type-based reasoning about the correctness of programs that can incorporate computational effects such as accessing memory, raising and handling exceptions, making nondeterministic and probabilistic choices, and communicating over a network---all integral features of modern mainstream programming languages. The timeliness and importance of this project is demonstrated by the staggering cost of software failure in our increasingly digital world---one recent study put the number at $1.7 trillion worldwide in 2017 alone. While there already exist different approaches to type-based reasoning about the correctness of effectful programs, they all have their notable shortcomings: the approaches might be tied to a specific typing discipline, the supported effects can be limited, and the kind of properties one can reason about may be restricted. In contrast, the LiquidEff project aims to develop a foundational, uniform, and widely applicable framework for type-based reasoning about effectful programs, based on the highly scalable and modular algebraic approach to modelling computational effects. Specifically, this project will 1) develop an expressive modal logic for reasoning about a wide range of computational effects; 2) show that this logic can express existing effect specification styles; 3) demonstrate that it can be used to design refinement type systems for lightweight type-based reasoning about effectful behaviour, thus giving a general account of the Liquid Effects effect-typing discipline that so far has been restricted to the state effect; 4) study the category-theoretic semantics of these foundations; 5) implement LiquidEff, an extension of the Eff language with a support for light
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Research into Various Exact and Numerical Aspects of Critical Phenomena' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A cornerstone in the study of phase transitions is the principal of universality. This maintains that entire families of systems behave identically in the neighbourhood of criticality, such as the transition point between a liquid and a gas or at the Curie point in a magnet, at which two phases become indistinguishable. Near the critical point, thermodynamic observables and critical exponents do not depend on the details of intermolecular interactions. Instead they depend only on the range of interactions, symmetries and spatial dimensionality. This fact allows us to understand real materials and systems through simplified mathematical models.The universality concept is commonly stated together with the hypotheses of scaling and finite-size scaling.  The associated theories have been mostly successful in describing critical and non-critical properties, but significant discrepancies between them and experiments remain. To understand the experiments, the theories have to be improved. This project seeks to increase our understanding by researching corrections to scaling. Our proposal is to investigate statistical mechanical models in an attempt to place our theoretical understanding of critical phenomena closer on firmer ground and to render them closer to experimental measurements.We will especially target universality, scaling, and finite-size effects in two dimensional models of statistical mechanics as these can be tackled using exact methods, as well as analytic and numerical ones. In addition, more challenging three dimensional models will be investigated.Theories of critical phenomena in particular are crucial in our understanding of how everything depends on everything else in many disciplines outside physics. It thus permeates all of natural sciences and even beyo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Scale-up for Next Generation Enzymatic DNA Synthesis' (Rosalind), addressing dissemination and exploitation.

assistant: **Impact**

DNA Script is a biotech company founded in 2014, developing an enzymatic process for DNA synthesis, i.e. manufacturing DNA. Creating DNA is crucial for R&D in numerous fields of synthetic biology which tackle essential societal issues: climate change thanks to the production of bioproduced materials, healthcare with new biotherapies - especially against cancer, or food security using better strains of plants. Synthesis is also an essential step towards of DNA data storage. All these applications form the long-awaited synthetic biology revolution, and all rely on the capability to efficiently write life code to engineer biological systems. Current DNA synthesis methods are the major bottleneck. The enzymatic process developed by DNA Script, inspired by Nature, aims at improving both speed and efficiency by orders of magnitude. Avoiding the use of toxic reagents, this process will also contribute to a lower environmental footprint for this industry, as well as for its downstream applications.DNA Script’s technological performances in the lab are 3 to 6 months away to overcome current offer. Project Rosalind will accelerate industrial scale-up of DNA Script’s production capability and performances. By developing extensive knowledge in DNA applications and structuring the company’s strategic and commercialization capabilities, Project Rosalind will also help DNA Script go commercial.Enabling technologies such as DNA synthesis have tremendous impact on an ecosystem by accelerating R&D and industrialization cycles of its customer. The project will have a positive impact on the European biotech environment, and potentially trigger the emergence of European biotech leaders. Ultimately, through the numerous applications of synthetic DNA, it will benefit all European citizens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding the importance of viral Fitness Impairment after Transmission of HIV: Implication on HIV vaccine design' under Seventh Framework.

assistant: **Concept**

There is an urgent need to develop effective prophylactic and therapeutic vaccines to combat the human immunodeficiency virus (HIV)/AIDS pandemic, currently responsible for ~2 million deaths/year worldwide. The challenges encountered in developing vaccines to elicit broadly-neutralizing antibodies capable of blocking infection with diverse HIV strains, together with the wealth of evidence showing the importance of HIV-specific CD8 T cells in control of virus replication, have prompted efforts to develop T cell-inducing vaccines to combat HIV. However rational vaccine design is hampered by the current lack of understanding of features of an optimally-protective HIV-specific T cell response. HIV’s ability to evade T cell control by mutating to escape from T cell recognition suggests that it may be critical for vaccines to elicit broad T cell responses to limit viral escape. However T cell escape mutations can have fitness costs that may offset the effects of escape; furthermore transmission of unfit virus could lead to reduced viral replication in the recipient. We propose to perform an in-depth prospective analysis of viral interactions with the host CD8 T cell response in acute HIV infection to determine the importance of i. the fitness of the transmitted virus ii. the extent and kinetics of viral escape from the earliest CD8 T cell responses and iii. the viral fitness cost incurred in escaping from these early responses, in determining the prognostically-important set-point persisting viral load. This unique analysis of virus-host interplay will be made possible by the expertise in state-of-the-art molecular virological techniques that the fellowship applicant will bring to complement the host laboratory’s immunological expertise. Results from this study will give insi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Evaluation and implementation of post-quantum cryptographic schemes' (IDPOQ) under Horizon 2020.

assistant: **Objectives**

Quantum computers are devices under development that offer an immense computational capability, outperforming all actual and forthcoming classical computers. If practicable, they would have a dreadful impact on the security of our communications. Indeed, quantum computers will be able to solve mathematical problems that are infeasible today, and all currently used cryptographic schemes (i.e. the tools used to provide confidentiality, authentication, and integrity to our communication channels) rely on the hardness of such problems to ensure their robustness. Such a weakening of the security of our telecommunications would impair many aspects of our society, both in the EU and all around the world, from online shopping and financial transactions to military communications and state secrets. This research project aims at evaluating and analysing the robustness of several cryptographic schemes against attacks led with a quantum computer, and once provably secure ones are found, implementing them. At first, it will be focused on a specific family of encryption method, the lattice-based ones, which are among the most promising candidates from the resilience and performance trade-off point of view. A significant part of the proposal is devoted to the implementation of the analysed schemes. These implementations will adopt various forms which aim at different objectives, such as freely-available standardized softwares or hardware integrated within ID Quantique (the beneficiary, a Swiss company providing quantum-safe cryptographic solutions) line of commercialized devices.Our proposal will take advantage of the post-quantum project initiated by the NIST, an international program which aims at soliciting, evaluating, and standardizing quantum-resistant cryptographic algorithms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Quest of the Argonautes - from Myth to Reality' (ARGO).

assistant: **Concept**

Argonaute nucleases are key players of the eukaryotic RNA interference (RNAi) system. Using small RNA guides, these Argonaute (Ago) proteins specifically target complementary RNA molecules, resulting in regulation of a wide range of crucial processes, including chromosome organization, gene expression and anti-virus defence. Since 2010, my research team has studied closely-related prokaryotic Argonaute (pAgo) variants. This has revealed spectacular mechanistic variations: several thermophilic pAgos catalyse DNA-guided cleavage of double stranded DNA, but only at elevated temperatures. Interestingly, a recently discovered mesophilic Argonaute (CbAgo) can generate double strand DNA breaks at moderate temperatures, providing an excellent basis for this ARGO project. In addition, genome analysis has revealed many distantly-related Argonaute variants, often with unique domain architectures. Hence, the currently known Argonaute homologs are just the tip of the iceberg, and the stage is set for making a big leap in the exploration of the Argonaute family. Initially we will dissect the molecular basis of functional and mechanistic features of uncharacterized natural Argonaute variants, both in eukaryotes (the presence of an Ago-like subunit in the Mediator complex, strongly suggests a regulatory role of an elusive non-coding RNA ligand) and in prokaryotes (selected Ago variants possess distinct domains indicating novel functionalities). After their thorough biochemical characterization, I aim at engineering the functionality of the aforementioned CbAgo through an integrated rational & random approach, i.e. by tinkering of domains, and by an unprecedented in vitro laboratory evolution approach. Eventually, natural & synthetic Argonautes will be selected for their exploitation, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The inhibition of sorting proteins as a therapeutic avenue in HER2 positive breast cancer' (SaveHER).

assistant: **Concept**

HER2+ breast cancers are an aggressive type of breast cancer and have a poor prognosis. There are many therapies currently on the market to target this type of cancer, however they fail to deliver effective clinical results due to therapy resistance. In our ERC-CoG project, we found that proper endosomal trafficking is required for functional HER2 oncogenic signalling at the plasma membrane. Targeting HER2 endosomal traffic can result in effective treatment of HER2+ cancers, without the risk of therapy resistance. As such, this innovation could deliver the first truly effective cancer treatment for HER2+ breast cancer patients that do not respond to current treatments. In this ERC-PoC, we aim to prove that therapeutic targeting of endosomal traffic is effective in HER2+ cancer models in vivo, as a monotherapy and synergistically with current therapeutic antibodies, and to explore the commercial avenues to exploit this finding.