RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bootstrapping Inflationary Cosmology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cosmic inflation is one of the most promising explanations for the origin of the structure in the observed universe. However, while quantum-mechanical fluctuations during an early epoch of inflationary expansion provides a remarkably good description of the data, establishing the precise field content during inflation is a fundamental challenge for primordial cosmology. Since it is almost certain that the inflationary era involved physics beyond the Standard Model, this is also an incredible opportunity to learn about physics at the highest energy scales from current and future cosmological observations.On the theoretical side, it is important to classify the signatures of new degrees of freedom in primordial correlation functions to compare with observations. However, progress has been hindered due to the lack of tools to go beyond the simplest of cases. I propose a research and training programme to develop new systematic tools at the interface between scattering methods in de Sitter (dS) space, and, via holography, the conformal bootstrap in the dual CFT picture, to carve out the non-Gaussianities associated to: (1) Regge trajectories of higher-spin fields predicted by string theory/other UV complete theories of gravity (2) partially massless higher-spin fields, both at tree and 1-loop level. This proposal combines my expertise on higher-spin theories, scattering methods on anti-dS and holography with extensive training on various aspects of inflation and CMB physics from world-leading experts at IAS Princeton. The project will be completed at ULB, whose complementary expertise on higher-spins and holography will provide fertile ground to transfer my knowledge gained from the outgoing phase and continue the directions generated by the project. The importance of the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EOSC Focus' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

EOSC Focus will support the co-programmed EOSC Partnership in delivering its mission of establishing Open Science as the “new normal” and achieving the key objectives, which are outlined in the Memorandum of Understanding between the European Union and the EOSC Association (EOSC-A).EOSC Focus is a collaboration of eight Members of EOSC-A and the EOSC Association AISBL itself – the hub of key stakeholders in the European research environment, which provides insights on overarching themes important for the realisation of EOSC. The consortium demonstrates excellent complementarity across the diverse regions and stakeholder groups needed to ensure appropriate coverage of countries and stakeholders. EOSC Focus will provide an effective EOSC stakeholder forum; consolidate and enhance existing monitoring frameworks; identify strategic gaps to inform future iterations of the SRIA; develop and test resourcing models for a sustainable EOSC; implement the EOSC Rules of Participation; and collaborate with other EOSC-related projects, other partnerships, and international initiatives. EOSC Focus is organised into six work packages: WP 1 Project Coordination; WP 2 Stakeholder Engagement and Management; WP 3 SRIA Update and Technical Development; WP 4 Monitoring and Impact Assessment, WP 5 Sustainability of EOSC, and WP 6 Communication, Dissemination & Stakeholder Forum. The combination of these work packages will help the sometimes divergent activities of the broader stakeholder community to focus on the big goal of delivering EOSC.The impact of EOSC Focus will contribute to the increased availability, accessibility, and re-use of data. It will make research results more accessible for citizens; it will increase the quality and outreach of science and thus lead to more results from s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploiting Gram-negative cell division targets in the test tube to obtain anti-microbial compounds' (DIVINOCELL) targeting Seventh Framework.

assistant: **Abstract**

The DIVINOCELL project will identify novel Gram-negative targets by exploiting the components of the divisome, their activities and interactions. It will also design selective assays for screening and will obtain a new class of antimicrobials: compounds to block bacterial division.  New medicines to attack Gram-negative pathogens will decrease the burden of infectious disease and have a highly beneficial social and economic impact in Europe and beyond. Cell division is an essential and still underexploited process with excellent properties to yield new inhibitors to attack infection by blocking the proliferation of pathogens. Inhibitors directed against bacterial division targets, that are not present in eukaryotic cells, will be both effective and innocuous to humans and animals. In addition, as many of their structures will be based on interaction domains and synthetic scaffolds, they will generate resistance at levels lower than the present antibiotics. DIVINOCELL will apply existing and new knowledge on the molecular biology of Gram-negative cell division as well as novel analytical (nanodiscs), bioinformatic (molecular dynamics), structural (membrane protein crystals) and imaging (lanthanide staining) tools to exploit in the test tube the structures and interactions of targets in the divisome and the septum. DIVINOCELL will develop potent systematic screening assays and will use them to select compounds specifically tailored to inhibit the division of Gram-negatives (not precluding broad spectrum ones). Secondary activity and cell assays, based on the properties of bacterial division, will be generated to validate hits and advance them to leads. The medicinal properties of selected leads will be improved. The translational steps of the project will be developed by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unveiling novel deeply branching protist lineages to reconstruct major evolutionary events in the early history of eukaryotes' (EUKPHYLEVOL).

assistant: **Innovation**

Animals, plants, and fungi, which evolved multicellularity independently from their unicellular ancestors, represent only a small minority of the many branches on the eukaryotic tree of life, while the most of eukaryotic diversity is represented by microbial eukaryotes, or protists. Heterotrophic flagellates have been found in all major eukaryotic lineages and represent the most ancient and ancestral cellular organization. Heterotrophic flagellates often occupy early-branching or intermediate evolutionary positions within eukaryotes, thus comprehensive studies of novel lineages of heterotrophic flagellates not only fill the gaps in microbial diversity and phylogeny, but also help to understand the origin and evolution of major, well-known and diverse eukaryotic groups. Moreover, elements of the flagellar apparatus are homologous in all eukaryotes and are an excellent tool of comparative morphology to help interpret molecular phylogenetic data. The main goal of this project is to culture new and important protist lineages occupying key positions in the eukaryotic tree of life and to characterize their biology by linking sequence information to morphological, life history, and ecological traits. I propose two parallel Objectives on morphological and molecular characterization of previously unknown and understudied deeply branching lineages of eukaryotes, Collodictyonida and Rhizaria, that are both of critical importance in understanding eukaryotic evolution.


**Keywords:** heterotrophic flagellates, protists, early eukaryotic evolution, molecular phylogeny, morphology, ultrastructure, light and electron microscopy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CAncer Stem Cell Imunoreceptors as potential Targets for skin Squamous cell carcinoma' (CApaCITy) targeting Horizon 2020.

assistant: **Abstract**

Cancer stem cells (CSC) initiate, sustain the prevalence, and resistance to therapy of skin squamous cell carcinomas (SCC). It is well acknowledged that CSC self-renewal and clonal growth is governed by genetic mutations, but also by complex interactions between CSC and the microenvironment. Genetic therapy is difficult to achieve in clinical settings, therefore, targeting cells of the supportive tumor microenvironment is a promising advance to eradicate SCC. Using mouse models of SCC, our previous basic research results uncovered the existence of a direct crosstalk between skin CSC and tumor-associated macrophages (TAM) via Wnt signaling. Interestingly, we observed that Wnt regulated the expression of three CSC receptors, CD99, MFGE8 and Nectin-2, and governed the CSC-TAM crosstalk. Here, I propose to expand this basic research into a translational perspective, to explore the potential of CD99, MFGE8 and Nectin-2 as therapeutic targets for human SCC. There is a major interest in this arena, since the major caveat of targeting Wnt signaling in cancer is the lack of specificity to target CSC, without affecting somatic cells. Moreover, most clinical trials have not been fully efficient to dampen the Wnt response in tumors. Using a comprehensive and integrated approach based on human SCC, cell biology, omics and medical chemistry, along with powerful patient derived xerographs (PDX), my results must likely unearth a role for these immunoreceptors in governing the CSC-TAM crosstalk, and their potential as drug targets for human SSC. This interdisciplinary project will be conducted at the University of Copenhagen (UCPH) in Dr. Perez-Moreno, Dr. Merete Haedersdal, and Dr. Strømgaard groups. Through the CApaCITy project, I will embark in a leading research area with several po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Star formation quenching and feedback in galaxies throughout the cosmic epochs'.

assistant: **Innovation**

Throughout the whole life of the universe only 4% of the baryons have beenconverted into stars, implying that some physical processes must be responsiblefor suppressing star formation in galaxies. Within this context, one of themost hotly debated open questions is the identification of the processresponsible for quenching star formation in galaxies and transforming them into passive and quiescent (gas poor) systems. Theories of galaxyformation have proposed various possible mechanisms, such as: gasremoval by powerful outflows or ram pressure stripping, heatingand photoionization of the interstellar medium, turbulent orgravitational quenching, halting of the gas supply inflow (often referred to as ""strangulation""). The relevance andrelative role of these mechanisms (as a function of cosmic epoch, galaxy properties and environment), especially at high redshift, are not yet understood because the constraints providedby current observational data have not yet been able to discriminatebetween different scenarios.In the proposed project I will make use of some of the most advanced observational facilities that will be available in the coming yearsto tackle this major outstanding open issue. More specifically, I willexploit the James Webb Space Telescope, MOONS (the next generationmulti-object spectrograph at the ESO-VLT) and the Atacama Large MillimeterArray (ALMA).Observing programs making use of these unique facilitieswill provide an unprecedented amount of information, with unprecedented quality, that will enable us to discriminate between various quenching and feedback processes proposedby theories. More specifically, the aim of this project is toidentify and quantify the dominant quenching and feedback mechanisms in galaxies as a function of redshift, as a function of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development and commercialisation of a sustainable, energy efficient and scalable bioprocessing technology to enable sustainable cell-based manufacturing', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

It is widely reported all over the world that primary recovery of cells from bioreactor systems are currently underserved by the existing technologies of filtration, flocculation and centrifugation. This is due to both the volumes of liquid required for economical production and the number of cells or particles suspended in them. Where these biological cells can produce an enormous range of products such as medicine, food, cosmetics, pigments, nutritional supplements, plastics and fuel; the industries active with this sustainable method of production are burdened by stagnant and inefficient technologies for the harvesting of these cells.   We, uFraction8 Limited, have developed a technology 'HuMBLES' designed to address this need for a scalable, low energy primary recovery solution. Using massively multiplexed modular microfluidic arrays,HuMBLES is readily scalable to address the needs of bioprocessing industry.  Leveraging the ability to scale microfluidics throughput out of the lab and into industry promises, this Phase 1 project is focused at exploring the techno-economic feasibility of using multiplexed microfluidic arrays to for harvesting of microbial cell cultures to enable sustainable bioproduction.   Successful development and commercialisation of HuMBLES will enable the economic production of goods using sustainable cell based manufacture, hence transforming industry to the great benefit of the environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Atto-calorimetric tools to explore material properties in the nanoscale' in the context of a Seventh Framework call.

assistant: **Objectives**

Nanoscale phenomena where the surface/interfaces or the small dimensions play a predominant role in the physical properties have become increasingly important in the last decade. Many characterization techniques have been adapted to face new challenges and understand new phenomena and calorimetry is no exception. ATTOCALMAT project pursues the development of a new nanocalorimetric technique the ’microsecond-pulsed steady-state method’ that will combine the signal enhancing of the fast scanning and the advanced signal averaging of steady-state techniques. Preliminary results with sensitivities of 5 pJ/Kmm have already shown an improvement by a factor of 50 compared to the best steady state techniques. With the scaling down of the Si-nanochips (sensing areas~200 nm^2), the addenda reduces to few fJ/K. The increase of surface selectivity is followed by the sensitivity with values of 0.2 aJ/K. Chips with a monocristalline Si layer below the SiNx membrane will easy the study of epitaxial materials. With the new cutting edge technique and the nanochip measurement of heat capacities of single nano-objects as function of temperature but also of external variables (like magnetic and electrical field, time…) are within reach. This thermal tool will be applied to underpinning the physical properties of materials that represent a leading edge research frontier in nanoscale science towards its end-use in potential applications as magnetic storage, spintronics or photonics.Several of the challenging and unexplored measurements proposed are:(i) Magnetocalorimetry to detect Néel’s wall formation in the antiferromagnetic material of an exchange biased system on physical properties. (Co/CoO or Ni/NiO)(ii) Measurements of energy involved on the 2D-3D transition of  Ge epitaxial heteroestr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Isolation and characterization of mobile sRNA/target pairs in plants by using a viral protein as a probe' to be submitted under Horizon 2020.

assistant: **Abstract**

In plants, RNA interference (RNAi) is involved in processes ranging from development to stress responses. The core element of this regulatory mechanism, the small RNA (sRNA), has been characterized as a mobile molecule able to spread the RNAi beyond the initiation sites, acting as a cell non-autonomous process. Examples of mobile sRNAs are known: mobile small interfering RNAs (siRNAs) deriving from viruses spread throughout the plant, and are responsible for the activation of the viral silencing in uninfected tissues; other siRNAs, together with microRNAs (miRNAs), have been described to move through different cell layers, acting as morphogens; finally, some miRNAs have been shown to move through the vasculature under stress conditions, activating protective responses. Mobile sRNAs are therefore of capital importance for plant biology, and many approaches have been followed to analyze them; however, the number of mobile sRNA/target pairs fully characterized is scarce. Recently, the C4 protein from Tomato yellow leaf curl virus (TYLCV) has been shown to interfere specifically with the cell-to-cell movement of RNAi, affecting neither accumulation nor activity of the sRNAs. In this project, C4 will be used as a novel and powerful tool to isolate mobile sRNAs and their targets, under different conditions (basal vs viral infection) and in different plants (Arabidopsis and tomato), in a large scale and with unprecedented resolution. By using C4-expressing plants, out-of-location mobile sRNAs as well as increased levels of their unprocessed targets are expected to be easily detected. Thanks to this viral probe, a whole picture of the different populations of mobile sRNAs and their targets will be obtained, and the biological relevance of the most prominent candidates will be a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Epigenetic profiling of menstrual blood for precision cancer detection and prevention' (EpiPrecise) under Horizon Europe.

assistant: **Objectives**

Cancer has overtaken cardiovascular disease as the number one cause of mortality in high income countries, cancer incidence is increasing across the globe. Morbidity and mortality from womens cancers, particularly breast, ovarian, and endometrial cancers, follow or exceed these general trends in cancer incidence. Tackling this growing cancer burden requires a multifactorial approach including understanding the fundamental drivers of cancer development; improving methods for detecting earlier those forms of cancer with the worst prognosis; predicting a persons risk of developing cancer; and identifying appropriate targets for preventing cancer. Indeed, one of the biggest obstacles in identifying tailored cancer prevention strategies is a lack of surrogate readout markers reflecting and integrating an individuals response to the cancer-initiating and cancer-promoting factors that they are exposed to during their lifetime. Our research delivers novel epigenetic tests relating to each of these key areas with an emphasis on womens cancers and those who are at an increase risk for cancer due to their underlying genetics, such as women with BRCA1 or BRCA2 mutations and women with Lynch Syndrome. Central to the discovery and development of the epigenetic tests is a cellular deconvolution algorithm that is used to calculate the proportions of cell types within complex, mixed samples such as cervical swabs. In order to broaden the clinical utility of the tests and explore new applications, refinement and expansion of this cellular deconvolution algorithm is now required. The expansion will include cell types in menstrual blood, which is an important and understudied clinical sample type. The EpiPrecise project will deliver this refined and expanded algorithm and apply it to a tes