RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Human health and migration in prehistory' (PALEoRIDER), addressing dissemination and exploitation.

assistant: **Impact**

Recent ancient DNA studies have discovered a basal form of Yersinia pestis, the causative agent of bubonic plague, in 5,000 year-old individuals from Eastern and Central Europe. Even though this strain is an early form that does likely not survive in fleas and might have been less transmissible, the timing intriguingly coincides with a period of substantial societal changes. The archaeological record of 3rd millennium BC Europe clearly demonstrates the demise of terminal Stone Age and the rise of Bronze Age societies across the continent. This turnover has so far been explained by factors such as climatic changes or the advent of new metal working technologies and associated trading networks, which led to a reorganization of past societies. However, contemporaneous genomic data from ancient Europeans have attested major genetic upheavals in Europe 5,000 years ago, with an introgression of 75% genetic ancestry from mobile groups from the eastern steppes appearing in Central Europe. This substantial contribution suggests that early outbreaks of infectious diseases, such as plague, are a vital alternative explanation for large-scale population replacements and thus an attractive hypothesis for investigation. With well-preserved ancient human samples from relevant time periods and key regions in Europe at our disposal, we have a unique and ideal test case to track evolutionary relationships between the human genome and pathogens through time. We will specifically target an extensive number of variants in human immune-related loci using state-of-the-art DNA capture assays alongside deep sequencing of microbial shotgun and pathogen data, which permits a direct characterization of human-pathogen co-evolution. This unique temporal framework will allow us to detect loci under se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Instrument-free 3D molecular imaging with the VOLumetric UMI-Network EXplorer' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Current molecular imaging and spatial transcriptomics methods are limited in throughput and affordability, and are constrained by inherent 2-dimensionality. We propose the Volumetric UMI Network Explorer (VOLUMINEX), a 3D implementation of sequencing-based microscopy. This radical alternative to optical imaging builds spatial molecular maps by sequencing DNA barcode networks where each node is a clonally amplified DNA patch, and each edge indicates inter-node proximity. The resulting network reveals gene identities along with their locations without a reference map. We propose an end-to-end pipeline starting with a tissue, followed by enzymatic processing steps, and ending with sequencing and a computational reconstruction to form a molecular image. We envision this procedure as an off-the-shelf commercial kit, offering an inexpensive alternative to advanced imaging instrumentation, expanding access to more researchers and potentially even clinical diagnostic settings. We are led by a Stockholm-based tech-dev team with seminal contributions to the field of sequencing-based microscopy, and a Stockholm-based company Single Technologies AB with a proprietary 3D sequencing device uniquely suited for validating our technology. We have partnered with an Utrecht-based team of life scientists to develop and deploy our technology on organoids, a rich controllable model tissue-like system perfect for exploring 3D biological imaging. Finally, at the heart of the project are undiscovered laws and physical principles which we aim to uncover and exploit with our Paris-based team of theoreticians, who will develop optimisation, graph theory, and machine learning algorithms to tackle the challenging computational problem of spatial reconstruction presented by sequencing-based microscop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding the Intuitive Foundations of Democratic Norms and Procedures' (INFODEM) under Horizon Europe.

assistant: **Objectives**

We live in a new age of democratic backsliding. Democracies are not falling to coup d’etat, nor are they subverted by blatant vote fraud. Democracies fall by the hands of democratically elected executives, who erode certain democratic norms, while preserving others and maintaining public approval. It is now crucial to understand why and to what extent certain norms and procedures of democracy are more understood, supported, and monitored than others. The vast literature on support for democracy has paid surprisingly little attention to variability in support across the diverse norms and procedures of democracy. Bridging insights from moral psychology and democratic theory, INFODEM develops an original framework to study democratic norms. This novel intuitive theory of democratic norms argues that several aspects of contemporary democracies appeal to fast and spontaneous moral intuitions that value coordination, conflict resolution, and exchange. The theory predicts that whenever moral intuitions and democratic principles align, people understand, support, and vigilantly monitor democratic norms and procedures. This ambitious theoretical framework will be subjected to extensive empirical testing combining innovative methods including experiments with adults and young children, as well as a large, 30-country comparative study. Based on these scientific insights, INFODEM develops an interactive online tool called a Democracy Advice Application, to educate citizens about democratic norms and procedures and the state of democracy. As a proof-of-concept, the application will be tested and disseminated in Hungary. The INFODEM project contributes to our understanding of human nature and the current challenges facing democratic systems. It also helps to identify the vulnerabilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Closing the fibre-reinforced composites loop: recycling materials for recycled components' under Horizon Europe.

assistant: **Concept**

Lightweight fibre-reinforced composites are a key technology for a sustainable society and have been largely employed in several industrial sectors: sport equipment, wind energy, automotive, aerospace and more. Their recent widespread adoption, however, was not matched by a similar advancement of technologies for their recycling and disposal. In the next three decades, between two and three million tons of composites waste are estimated to be produced globally. Landfilling or incinerating such an amount of material, as it is done today, would significantly compromise the fight against climate change. Future scientists and engineers will thus need to efficiently dispose of such waste in a sustainable way. FibReLoop thus aims to train 14 innovative researchers that: 1) have a multi-disciplinary background expertise on all circular economic aspects of fibre-reinforced composites; 2) are able to identify, develop and commercialise key technologies and research opportunities for the sustainable development of composite materials; 3) can communicate efficiently with industrial partners, academics, media, policy makers and the general audience. FibReLoop researchers will be supported by a holistic training programme, provided by the 6 academic and 8 industrial partners of the project. The researchers will be involved in all the phases of the recycling process of composite parts: i) the analysis and development of recycling techniques, ii) the material characterisation and modelling of the recycled composites and the reclaimed constituents, iii) the design of components made of recycled composites, iv) their industrial adoption and finally v) the life cycle assessment of recycling processes and recycled materials. Overall, FibReLoop scientific advancement will allow to fully co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Cellular production of human recombinant collagens, gelatins, laminins and growth factors and their use in vascular grafts and other applications'.

assistant: **Objectives**

Collagens and laminas have crucial roles in the extra cellular matrix. Collagens have many applications in medicine, cosmetics and commodity products. Collagens presently used for such applications are derived from animal tissues. We will develop efficient recombinant production applicable to any given collagen type, and test the efficacy of the produced human collagens in several applications. We will also develop man-made basement membranes composed of suitable combinations of collagens; laminas and growth regulators endogenously present in these therapeutically important specialized matrices, and test their use in improving the endothelialization of vascular grafts. Furthermore, we will develop recombinant production of gelatine used in numerous applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'EGNSS DFMC for GBAS bAsed opeRations'.

assistant: **Objectives**

EDGAR (EGNSS DFMC for GBAS bAsed opeRations) Project aims at contributing towards the development of an improved, more liable, and accurate GBAS solution that responds, on the one hand, to the increasing demand for enhanced approach and all-weather operations in the ever-growing volume of air operations; and on the other hand, to sustainability requirements towards the compliance with EU Green Deal objectives. Being GBAS an enabler of enhance approach and optimised descent operations permits the reduction of noise footprints, fuel consumption and emissions, thus contributing to greener flights. Moreover, this project pursues to contribute to the goal of an early Dual-Frequency Multi-Constellation, or DFMC, GBAS adoption that allows facing ILS CAT III rationalization thanks to the increased robustness and thus rendering benefits to the aviation community. Therefore, the application of GBAS alongside EGNSS will technically improve the current system and will have a positive impact on the economy and society.Hence, the main objectives of this proposal are: to further develop and validate the GBAS DFMC solution so as to modernise and improve air operations, with emphasis on providing safety, availability, and robustness in all situations, including during challenging to ionospheric conditions; to analyse the distinguishing features of Single-Frequency Multi-Constellation, or SFMC, GBAS brought by the addition of Galileo; and to facilitate CAT II service to GAST C airborne users based on a GAST D ground station with EGNSS integration (GAST C and D correspond to standardized single-frequency single-constellation equipment able to provide CAT I and III performances respectively).


**Keywords:** GBAS, DFMC, EGNSS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Microfiber Electrofluidics for Integrated Molecular Diagnostics' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Diagnosis of an increasing number of diseases (such as HIV, Ebola and antibiotic resistant bacteria) rely on centralized laboratories with specialized instruments and skilled personnel. This type of clinical analysis with long lead times and high cost is inappropriate for point of care diagnostics. Portable, automated, and disposable devices with integrated molecular diagnostics (iMDx), could solve this problem. Such devices, however, basically do not exist today. This research program will develop materials, methods, and diagnostic techniques to enable portable integrated molecular diagnostics (iMDx) devices, that are disposable (almost zero-cost), and that can detect a broad range of diseases using DNA amplification. To achieve this, we will develop ""3D microfiber electrofluidics (MEF)"". MEFs rely on simple and readily available porous sheets including paper, and textiles. Their fabrication is simple, and yet they are very powerful because they can monolithically integrate 3D microfluidics, 3D microelectronics, electrochemical analysis, storage of reagents / biomolecules, as well as handling and manipulation of cells. We will develop techniques, using the combined capabilities of MEFs, for real-time DNA amplification and electrochemical DNA detection directly from samples. We will use three amplifications techniques for realizing a comprehensive iMDx platform: i) DNA detection, using established and state of the art amplification methods (e.g. PCR, LAMP, RPA). ii) RNA detection, using ""nucleic acid sequence-based amplification"" (NASBA). iii) Protein detection, using antibody to DNA translation through ""proximity ligation assay"" LPA, and using the detection of the amplified DNA is the indirect measure of proteins.The outcome of this program has the potential to b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Self-Calibrated Interferometry for Exoplanet Spectroscopy' (SCIFY), addressing dissemination and exploitation.

assistant: **Impact**

The spectral characterisation and understanding of terrestrial exoplanets is currently one of the most ambitious and challenging long-term goals of astrophysics. All observing techniques with the potential to tackle this challenge face the same limitations: the overwhelmingly dominant flux of the host star and/or the lack of angular resolution. A very promising technical solution around these issues is nulling interferometry, which combines the advantages of stellar interferometry (high angular resolution) and coronagraphy (starlight rejection). For several years, we have been developing both data acquisition and data processing techniques based on self-calibration of the interferometric observable and demonstrated record-breaking starlight rejection on two American ground-based facilities.  With the SCIFY project, I propose to prototype the first nulling interferometric instrument for the European Very Large Telescope Interferometer. By leveraging its state-of-the-art infrastructure, long baselines, and strategic position in the Southern hemisphere,  the new VLTI instrument will be able to carry out several high-impact exoplanet programmes to characterise the chemical composition of Jupiter-like exoplanets at the most relevant angular separations (i.e., close to the snow line) and better understand how planets form and evolve. To achieve these goals, we will demonstrate a new observing technique called spectral self-calibration, combining nulling interferometry with high-dispersion spectroscopy, and adapt our advanced post-processing techniques to the VLTI. This will provide a new and more robust open-source general-purpose interferometric data reduction tool to the VLTI community. In the long term, the SCIFY project will be a cornerstone in the roadmap leading to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Functional Analysis of Caveolae - and Lipid Raft-mediated Endocytosis'.

assistant: **Innovation**

The objective of this project is to elucidate the molecular mechanisms underlying a novel pathway for the endocytosis and intracellular trafficking of caveolae. It has recently become clear that molecules partitioning in lipid rafts do not always follow the classical clathrin-mediated pathway but can be internalized via a distinct caveolae-mediated route. First, I will develop fluorescence microscopy-based assays to analyze the intracellular trafficking and dynamics of caveolae upon internalization from the plasma membrane. Second, I will design a screening assay to identify key molecules involved in caveolae-mediated endocytosis by targeted, genome-wide RNA interference. Complementary, proteomics will be performed on isolated endocytic intermediates. We have the following aims:  1. To develop assays, using new light microscopy techniques that allow us to visualize and quantify the internalization and trafficking of individual caveolae in living cells. 2. To obtain a list of genes functionally involved in caveolae-mediated endocytosis, using genome-wide RNA interference screening. 3. To isolate caveosomes, to determine their constituents by proteomics analysis, and to design in vitro membrane traffic assays. 4. To obtain putative functions of the molecules identified in 2) and 3) with systematic database mining, sequence alignments and protein domain searches, and to use in vitro and in vivo systems established in 1) and 3) to test these predicted functions directly. This will provide complementary training and will generate data on which an independent research career in the field of endocytosis can be based. The screens will provide a proof of concept for the research community and novel insights into yet uncharacterised membrane traffic events. A better understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mitochondrial gene eXpression' (MiXpress), addressing dissemination and exploitation.

assistant: **Impact**

Mitochondrial gene expression is essential for cellular metabolism and energy supply since 13 core subunits of the OXPHOS system are encoded on the mitochondrial genome. Despite its importance for cellular function, mitochondrial gene expression (mitoGE) and its regulation are not understood at a mechanistic level. To this end, we demonstrated that mitochondrial translation is prone to regulation, responding to influx of nuclear-encoded proteins . However, the mechanisms that regulate gene expression in mitochondria remain unknown. A lack of suitable experimental approaches to modulate mitoGE hampers progress in our understanding. Here I propose a project that takes the next big step towards understanding the mechanisms of mitochondrial gene expression. Our recent work on an in organello system to target mitoGE in a transcript-specific manner provides the bases for the challenging project proposed here, which aims to solve long-standing questions: First, we will dissect mitochondrial transcript interactomes and their spatial orchestration to understand basic principles of RNA abundance, organization in granules, and cross communication. Second, we are now able to investigate translation in the context of the inner membrane with transcript-specific resolution and thereby identify liaising factors involved in ribosome recruitment and membrane insertion and regulation. Third, we will extend our strategy towards an in vivo transcript-specific silencing approach to define retrograde signaling pathways that integrate mitoGE into cellular contexts. The combination of functional analyses carried out in organello and in vivo will provide unprecedented insights into components and mechanism of mitoGE and reveal how two genetically independent systems cooperate to build a function