RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Diversion of adherens junctions by bacterial type III effectors during Shigella invasion of polarized intestinal epithelial cells' under Seventh Framework.

assistant: **Concept**

Shigella is a gram-negative enteropathogenic bacterium responsible for dysentery in humans. The type III secretion system (T3SS) encoded on a large plasmid is a key virulence factor of Shigella. Upon epithelial contact, the T3SS allows the translocation of effector proteins into the target cells subverting host cell signal transduction pathways. These T3SS effectors reorganize the actin cytoskeleton through the targeting of RhoGTPases and tyrosine kinase signaling, leading to localized membrane ruffling and subsequent bacterial invasion of host cells. Recent evidence indicate that as opposed to what is observed in non-polarized cells, the coordinated activity of the T3SS effectors, IpgB1 and IpgB2 that activate RhoGTPases, is required for invasion of polarized intestinal epithelial cells that form highly organized intercellular junctions. Adherens junctions (AJs) are regulated by Rho GTPases and tyrosine kinases. In particular, the disruption of AJs linked to epithelial-to-mesenchymal transition (EMT) implicates signaling processes that are reminiscent to those observed during Shigella invasion. These results suggest that the diversion of AJs by these Shigella effectors is necessary for bacterial invasion. In this proposal, we will characterize signaling events mediated by T3SS effectors leading to the transient activation of an EMT-like pathway implicating RhoGTPases and tyrosine kinase signaling, accounting for the breaching of the epithelial barrier by this enteroinvasive bacterial pathogen. This proposal which addresses a key process of bacterial pathogenesis in a relevant epithelial cell system is likely to have profound implications on our understanding of mechanisms underlying the regulation of the epithelial barrier homeostasis and its manipulation by invasive p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cellular and molecular mechanisms of remote fear attenuation' (2014-2020).

assistant: **Concept**

Traumatic events generate some of the most enduring forms of memories. Despite an elevated lifetime prevalence of related fear and anxiety disorders, effective treatments for traumatic memories are scarce and the mechanisms behind successful memory attenuation poorly understood. This discrepancy is particularly pronounced for remote traumata, when the original insult occurred in the distant past.Here, we propose to identify, isolate to analyze, and causally determine neuronal subpopulations involved in remote fear memory attenuation. To achieve these goals, we will use a combination of transgenic mice with direct in situ manipulations of neuronal subpopulations and cell type-specific transcriptomic and epigenetic profiling. Specifically, we will inducibly and persistently tag neurons activated by remote memory recall, and subsequently capitalize on this tag threefold: First, by visualizing this tag after successful memory attenuation, we will identify neuronal subpopulations that promote remote memory reduction. Second, by using this tag as an anchor for pharmacological manipulations interfering with neuronal activity, we will determine a causal implication of these neurons in successful memory attenuation. Lastly, by employing this tag as bait, we will isolate neuronal subpopulations that promote memory attenuation to analyze their epigenetic regulation of gene expression, a core component of enduring forms of memories. By investigating these mechanisms in three independent protocols for memory attenuation, we seek to provide proof-of-principle that successful memory attenuation is defined by a unique molecular signature, which can serve as a template to better ascertain the potential of other treatments aimed at attenuating remote memories.We expect this project to de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Blue Bunkering of Anchored ships with Renewable Generated Electricity'.

assistant: **Concept**

The shipping industry is responsible for around 3% of global greenhouse gas emissions, and this is expected to increase as global trade and shipping activity continues to grow. As such, reducing emissions from shipping is an important part of global efforts to tackle climate change. In recent years, policies and legislation, mainly focusing on environmental sustainability, have pushed international shipping toward the process of its decarbonization. Regulatory bodies are pressing on the maritime world by adopting ambitious targets and by introducing a number of initiatives that will facilitate the transition to a sustainable future, including the International Maritime Organization's strategy to reduce greenhouse gas emissions from shipping, which aims to halve emissions from the sector by 2050 compared to 2008 levels.To this end, BlueBARGE will design, develop and demonstrate an optimum power-barge solution to mainly support offshore power supply to moored and anchored vessels, limiting local polluting emissions and global GHG footprint in a life cycle perspective, following a modular, scalable, adaptable and flexible design approach which will facilitate its commercialisation by 2030. The proposed power-barge solution will consider different alternatives as containerised power supply modules in a variety of configurations, where battery modules will serve as basis due to their high energy efficiency and readiness level, and other considered modules including hydrogen fuel cells and hydrogen generators. The project will address electrical integration issues, interfacing challenges of the barge with ships, ports and local grid, operational safety and regulatory compliance aspects, delivering a high-readiness and complete “power bunkering” solution. Overall, the BlueBARG
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Laminated Perovskite Photovoltaics: Enabling large area processing of durable and high efficiency perovskite semiconductor thin films.'.

assistant: **Objectives**

Photovoltaic technologies are cornerstones of all future scenarios for sustainable energy supply. Enhancing the efficiency and reducing the costs of photovoltaics is a challenge of utmost urgency and importance to the research field of materials engineering and science. To date, hybrid organicinorganic lead halide perovskite semiconductors denote the most promising material class for future low-cost and high-efficiency next-generation photovoltaics. Major hurdles that hinder the economic breakthrough are the low stability and the large-area fabrication of high-quality perovskite thin films. In response, LAMI-PERO will break new ground by researching and developing a novel lamination process that is designed to enable the processing of unexplored perovskite semiconductors and heterostructures, more durable thin film morphologies, and novel high-efficiency device architectures. My team and I were among the first to report preliminary data on this lamination process. It combines two half-stacks in a high-pressure step and allows crystalizing the pre-deposited precursor materials into a high-quality perovskite thin film. Thereby, the lamination disentangles critical constraints of established sequential layer deposition. To reach its ambitious goals, LAMI-PERO will (1) close the knowledge gap about the underlying physics of the perovskite film formation during the lamination process using innovative in-situ characterization, (2) explore more stable thin film morphologies and novel perovskite semiconductors, (3) fabricate more durable and high-efficiency perovskite solar cells and perovskite-based tandem solar cells, and (4) demonstrate the scalability of the lamination process in view of future commercialization. To date, the lamination of perovskite thin films is largely u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Molecular strategies to treat inherited arrhythmias'.

assistant: **Concept**

Sudden cardiac death (SCD) is a leading cause of death in western countries: coronary artery disease is the major cause of SCD in older subjects while inherited arrhythmogenic diseases are the leading cause of SCD in younger individuals. After 25 years dedicated to research of the molecular bases of heritable arrhythmias, the PI of this proposal now intends to pioneer gene therapy for prevention of SCD: a virtually unexplored field. The development of molecular therapies for rhythm disturbances is a high risk effort however, if successful, it will be highly rewarding. The PI has envisioned an ambitious and comprehensive project to target two severe inherited arrhythmogenic diseases: dominant catecholaminergic polymorphic ventricular tachycardia (CPVT) and Long QT syndrome type 8 (LQT8). The availability of a clinically relevant model is critical to ensure clinical translation of results: the team will exploit an existing CPVT model and will engineer a knock-in pig to model LQT8. The PI and her team will investigate innovative strategies of gene-delivery, gene-silencing and gene-editing to the heart comparing efficacy of different constructs and promoters. The team will also carefully engineer novel gene-therapy approaches to avoid the development of regional inhomogeneity in protein expression that may facilitate proarrhythmic events. Such a comprehensive approach will provide a most valuable core of knowledge on the comparative efficacy of a broad range of molecular strategies on the electrical milieu of the heart. It is expected that these results will not only benefit CPVT and LQT8 but rather they will foster development of gene therapy for other inherited and acquired arrhythmias.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Open broadband access networks' (OBAN) under Sixth Framework.

assistant: **Objectives**

The OBAN proposal introduces an innovative approach to establish a broadband mobile network in line with present B3G visions. The concept is based upon an Open Access Network (OAN) approach characterised by that all private wireless LANs and broadband access lines are made available for public use, thus the stationary users (the hosts) can continue to use their wireless LAN as before, and that casual passing users can access and maintain communication via these access points.The visitors and the stationary users will share the capacity of wireless LANs and access lines according to a general service agreement between the involved parties. It is assumed that the majority of private homes during a few years will have access to a broadband network over ADSL, VDSL, fiber, cable, radio, etc and that wireless technology will be the winning technology for in-house communication both for residential and business users. In urban areas, all these micro base stations will form continuous radio coverage allowing users to roam through the landscape while maintaining their communication sessions.Compared to conventional cellular mobile networks consisting of a limited number of optimally located out-door base stations and antenna masts, the OBAN network will consist of a much higher number of micro base stations randomly located. The main objective of the proposal is to explore, develop and demonstrate the most important functionalities, performance and opportunities of the OBAN concept. To realise the concept existing protocols and mechanisms have to undergo fundamental improvements and the following sub-objectives are therefore identified.Each of them contains innovative RandD aspects:- To develop/adapt access control and security mechanisms,- To develop/adapt appropriate mobility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Farmer clusters for Realising Agrobiodiversity Management across Ecosystems' in the context of a Horizon 2020 call.

assistant: **Objectives**

FRAMEwork is constructed based on the Farmer Cluster approach successfully implemented in the UK. FRAMEWORK will enrich and innovate existing Farmer Clusters by liaising with local and (inter)national stakeholder groups, and set up new, multi-actor, Farmer Clusters in different cropping systems in Europe, based on existing collaborations. The Farmer Clusters will be united in a European-wide self-sustaining network and linked with the Citizen Observatory and Information Hub that will facilitate farmer and citizen-based collection and sharing of harmonised, high-quality information on biodiversity and farming, and develop engaging online and offline activities to amplify awareness and understanding of biodiversity and Biodiversity Sensitive Farming across different stakeholders in Europe. The scientific contribution to these citizen-based activities will deliver the following outcomes: 1) Advanced ecological understanding of the drivers of biodiversity change in agricultural landscapes; 2) a selection of best-practice biodiversity-sensitive management by farmers based on their local requirement; 3) validated methods for biodiversity targeting, monitoring and evaluation and 4) private and public incentives to foster biodiversity-sensitive farming as a public good. Furthermore, FRAMEwork will assess the effectiveness of the Farmer Cluster approach to develop and implement place and system-specific biodiversity-sensitive farming practices and evaluate the economic and environmental performance, delivering a permanent on-line evaluation tool on the Citizen Observatory and Information Hub. The TRL of the Decision Support Tools ranges from 3-5, where improvements are foreseen for the TRL5 Decision Support Tool, while the ones at TRL3 will be brought to TRL4-5 through testing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Organometallic compounds for combinatorial synthesys' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Organometalic compounds play more and more important role in organic synthesis. The diversity of reactions and the versatility of these compounds reached a very high level. Despite of these facts application of these compounds is often not preferred, because of high cost or missing experience in house with a specific type of organometalic element.In the field of combinatorial synthesis the two most important factors, which have to be fulfilled is to produce a high range of compounds in a limited time to fulfil the costumer demanded deadline. That's why often high-catalyst loads are used. My goal is to bring my experience I acquired in organometalic synthesis and catalysis to help reducing unnecessary catalyst use. The practice proposed by the Environment Prote ction Agency (EPA) in their guide RCRA in the United States and The ROHS in the EU suggest to recycle as much precious metal as possible, not just because of the strategic importance of these elements, but even because the environmental consequences of the se heavy metals haven't been fully mapped.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EuroPean trAining NetwOrk on Rare eArth elements environMental trAnsfer: from rock to human', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

As Rare Earth Elements (REE) are crucial to a wide range of modern technologies regards to their unique properties, Europe expands its ability to obtain these strategic REE resources. Thus, several research and industrial projects were recently dedicated to the identification of potential REE stocks in Europe. However, the environmental risk exerted by the REE dissemination has so far received very little attention although disruptions of some REE biogeochemical cycles have been already evidenced. In that context, intensive and cooperative intersectoral researches are needed on REE environmental occurrence, behaviour, fate and their respective effects on natural resources (soils, waters and biota) and human health. The PANORAMA project is a unique multi- and interdisciplinary project aiming at (i) investigating the whole REE environmental behaviour including the characterization of sources, speciations and transfers throughout the different environmental compartments and sensu lato associated effects onto environmental health, as well as (ii) gaining valuable knowledge for applications in friendly environmental REE life cycle. For the 1st time PANORAMA gathers the competencies of (geo)chemists, (hydro)geologists and (eco)toxicologists, working in 14 academic and 4 private partners to enroll and train 15 Early Stage Researchers (ESRs). The project will combine training and cutting-edge research tools through coupled field/ analytical/experimental/modeling approaches. The strong blend of academic and non-academic sectors in the consortium will give the ESRs a unique chance to develop a wide set of fundamental research, technical and transferable skills (e.g. research integrity, communication and dissemination, career development and innovative technology), thus preparing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Glass-ceramic innovation ecosystem for implementation of new research directions in applications'.

assistant: **Objectives**

Productivity, competitiveness, and economic growth stem from innovation and are vital in collaborative research projects. However, given the heterogeneity of economic and industrial frameworks between North/Western Europe and South/Eastern Europe, open calls for European funded research projects often exacerbate the knowledge gap between more and less developed regions. This in turn, limits the economic impact of this funding on areas that often need it the most.Czechia and Slovakia have been growing their gross domestic expenditure on R&D, almost doubling it since 2005. However, this growth does not directly equal innovation, with patent applications per million of the population not reaching 15% of the EU benchmark.The GlaCerHub project will strive to support the virtuous innovation and economic cycle by capitalizing on the present-day competitive advantage of the advanced glass and ceramics industry to create a place-based innovation ecosystem in the border region between South Moravia (Czechia), and Trenčín (Slovakia), a region with long tradition in these areas.The GlaCerHub consortium will create a dynamic, specialist innovation ecosystem for the advanced glass and ceramics sector by stimulating new synergies between industry, academia, government, society and other European innovation Ecosystems. In the long term GlaCerHub will become a self-sustaining entity, supporting the creation, development, piloting and protection of strategic technologies, training of all stakeholders from the quadruple helix, and creating and supporting technology transfer.The long term impact will be to increase: - investment in glass and ceramics R&D - IP protection and patent applications- spin-off creation- intersectoral PhDs (and international PhDs)- licensing transactions- national