RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Digital testing of high-voltage power circuit breakers' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

ObjectivesThe relevant behaviour of a high-power circuit-breaker with respect to its ability to interrupt short-circuit current is mainly restricted to a short time window of a few tens of microsecond. The objectives of the programme are the following:* Development of a three-channel 40 MHz 12 bit resolution data-acquisition system for application in high-power laboratories* Extraction of relevant circuit-breaker arc parameters * Inclusion of arc models in suitable arc-circuit interaction computer software * Comparison of existing standards with the predicted interruption performance in various circuits and with various circuit-breaker technologies.ationsState of progressA new digital current-zero measuring system (having a sampling frequency of 40 MHz and a resolution of 12 bit) was used to monitor zero crossings of short-line fault currents in several designs of commercial high-voltage circuit breakers. The breakers were subjected to standard IEC 60056 short-line fault tests in a high power laboratory.From the database of test results, new empirical arc models are derived, eg based on the series connection of classical modified Mayr models.With the aid of such models, the influence of the (test-)circuit on the interrupting performance of circuit breakers can be evaluated, taking into account the individual characteristics of the breaker. Apart from this aspect, more direct evidence on the performance of breakers in IEC 60056 short-line fault tests can be gathered through evaluation of the arc resistance at current zero, or very close (few hundred ns) before current zero. Recently, high-power test were performed, in which this arc resistance (and the time dependent course of its limiting value) was used to compare the performance of two circuit breakers of the same rat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nmr structure validation: integration into the structure determination process.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The partners of the NMRQUAL project propose to: 1. include structure validation tools in all stages of the NMR structure determination process.2. Optimise existing validation tools and design new validation software for this purpose3. Define new quality indicators.4. Improve existing structure determination software by letting it use validation results.5. Integrate all stages of the NMR structure determination process by passing data and error estimates back and forth via standardized data exchange protocols.6. Design structure determination tools that use data in innovative ways.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Smart freight TranspOrt and logistics Research Methodologies' (STORM) targeting Horizon 2020.

assistant: **Abstract**

Freight transport and logistics are in a period of transformation where the increased availability of digital technologies is rapidly transforming market structures and logistics business models, and the legislative and policy frameworks are moving towards the minimization of the environmental impact of transport. The rapid structural, organisational, and behavioural changes of the sector make existing data, models, and tools lag behind current developments. In response, the STORM project aims to study transformation and structural changes in freight and logistics business structures from different perspectives, focusing on the future challenges and needs of the sector by developing new methods and tools to support digitalization, sustainability transition,   and future policy needs. STORM will create a unique platform for dialog with all relevant stakeholder groups to identify key elements for future horizons and directions for freight and logistics research, business and polices. The project will develop new generation, beyond current state-of-the-art transport data analytics, models and solutions through industry use cases and contribute to sector innovations and competitiveness. STORM output will be a toolbox bringing together tools and methods centring on Big Data, data fusion, and agent-based modelling applied to electrified freight transport concepts and new collaborative, digitised logistics systems. It responds to the emerging needs of transport researchers, planners, and policy makers and it will generate knowledge for the implementation of innovative transport policies. STORM will provide advanced methods and tools to enable new opportunities and business models for the sector through targeted information and knowledge sharing with structured support and coll
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Centreless grinding simulation part II', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The industrially applied centreless grinding and especially centreless through-feed grinding process is characterised by its complexity and sensibility. This process is used for mass-production of rotationally symmetric workpieces such as valves and piston rods. Up to 150.000 workpieces can be produced per hour with this process. The aim of CEGRIS II is to minimise the long set-up times of this process in order to enhance manufacturing productivity of European companies by at least 40%. By reducing the set-up time of the centreless grinding a higher process flexibility can be obtained which again increases the productivity. This goal is approached by developing a 3D model of the very complex centreless through-feed grinding process. This model will then be used to develop a software tool that will enable not only to help set up the machine tool but will also be able to predict the process outcome by pre-setting a given machine set-up. This software tool, and the 3D model will also be embedded in a cave-environment for a visualisation of the workpiece travel" through the grinding gap. This can be used for process demonstration and also for specifying machining problems. Together with the software tool and the 3D model the cave-embedded simulation represents the outmost edge of technology. Another very important goal of CEGRIS II is the drastic reduction of water-pollution by about 80%. Using a new filtering system and again pushing the boundaries of the state-of-the-art in this project this goal will be aimed at. The challenge in this project can be seen in enhancing European competitiveness in a global market that is dominated by low-wage countries. By enhancing the productivity of the centreless through-feed grinding process that is used in numerous machining processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improving the quality of life of mothers by early pre-natal diagnosis of developmental anomalies' (1998-2002).

assistant: **Innovation**

The most sensitive method for early non-invasive detection of fatal developmental anomalies is ultrasound examination between weeks 11-14, when embryonic development has been completed. Besides standard optometry, examinations include measurement of uncial translucency to screen for chromosomal anomalies, cardiac defects and also for determination of chorionicity of multiple pregnancies. Despite our extensive knowledge it has not yet been determined whether Tran abdominal or transvaginal ultrasound is the better tool for examining fatal anatomy between weeks 12 and 14, and whether 3D and 4D ultrasound can improve the visualisation of fatal organs at this gestational age. 2000 randomly selected patients attending routine first trimester ultrasound screening will be examined. Standard measurements will be carried out using 20 Tran abdominal ultrasonography as gold standard. In the same session pregnancies will also be examined by 2D transvaginal, 40 Tran abdominal and 4D transvaginal methods. It will be attempted to assess the role of Tran abdominal versus trasvaginal imaging in 3D and 4D ultrasonography in first trimester ultrasound, and will work out a detailed diagnostic protocol for ultrasound examinations at 11-14 weeks of gestation. The role of 3D and 4D ultrasound will be evaluated for the early first trimester detection of cardiac and morphological anomalies. The applicant will have the opportunity to gain experience in 2D, 3D and 4D first trimester prenatal ultrasonography and diagnostic workup of screened cases carrying fatal malformations. He will carry out a substantial number of the examinations under close supervision by an expert in fatal medicine. He will also gather experience in setting up and carrying out a research project, in data collection and analy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fuel cell application in a new configured aircraft' (CELINA).

assistant: **Innovation**

For the next aircraft generation the pneumatic and hydraulic systems will be replaced step-by-step by electrical systems. The goal for the future is to find a highly efficient primary electric power source. Fuel cell systems have the potential to be a highly efficient system with a significantly reduction of fuel consumption and noise and gaseous emissions. As a drop in possibility the fuel cell application as emergency power supply will be investigated. A feasibility study will be carried out to clarify in which operational scenarios like stand by, continuously running or power storage the fuel cell system is able to work. The technical focus of the project is therefore the investigation of the technical capabilities of an existing fuel cell system under special aircraft operation conditions and the identification of the needs for an airworthy design. Investigations of the behaviour and limiting conditions of the fuel cell system in terms of different system parameters such as performance output, thermal management, mass flow, cooling and air supply will be carried out. For these investigations dynamic simulation models of a fuel cell stack and a kerosene reformer will be used and verified by tests as far as possible. The scientific approach is the investigation of the operational behaviour of the complete fuel cell system including kerosene reformer, fuel cell stack, air supply and all subsystems based on simulation models in terms of aircraft environment operational conditions, aircraft load conditions, thermal management, mass flow, performance, air supply and cooling. A study works out the differences between the current fuel cell systems and an airworthy design and describes the technical steps, which have to be done to develop an airworthy fuel cell power system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolution of fungal mating-type chromosomes' (MatTypeEvol).

assistant: **Concept**

Sex chromosomes often show extensive areas of suppressed recombination and cytological differentiation, a well-documented phenomenon in animals and plants. Lack of recombination is expected to limit the efficacy of natural selection, leading to degeneration in gene content. Similarly, fungal mating-type chromosomes, which are responsible for controlling compatibility during mating, can display patterns of suppressed recombination encompassing up to 90% of the chromosome length. The mechanisms responsible for lack of recombination and consequent degeneration remain unclear.Here, I propose to use comparative genomics to investigate the patterns and underlying mechanisms involved in recombination suppression and genomic degeneration in Microbotryum, a model fungal system with a range of dimorphic mating-type chromosomes. I will complement the currently available high-quality genome assemblies for twenty species in the genus with three outgroups, which will allow to polarize all genomic data. I will then use the genomic dataset to: 1) test hypotheses on the origin of recombination suppression in fungal mating-type chromosomes; 2) study the evolution of non-recombining regions in fungal mating-type chromosomes, e.g., their size and age, and the existence of evolutionary strata; and 3) study the patterns and mechanisms of genomic degeneration in non-recombining regions, namely non-synonymous substitution accumulation, transposable elements, disrupted genes, and non-optimal codon usage.Results will not only shed light on the origins and consequences of suppressed recombination and genome degradation in fungal mating-type chromosomes, but will also yield unprecedented insights into the dynamics of sexual reproduction in eukaryotes and contribute for a unified view of the evolut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding of the Membrane Connection Linking the Nucleus to the Endoplasmic Reticulum' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Compartmentalization into membrane-bound organelles is a key feature of all eukaryotic cells, and communication between organelles needs to be tightly controlled. A key organelle for the inter-organelle communication is the endoplasmic reticulum (ER), which is the major site of lipid and membrane protein synthesis. The ER exchanges molecules by forming stable contact sites with multiple organelles such as mitochondria via specific tethering proteins and transporters. In contrast to these contact sites, the ER is linked to the nucleus via direct fusion to the outer nuclear membrane of the nuclear envelope (NE). These ER-NE junctions are essential for supplying the lipids and proteins that are synthesized in the ER to the NE. Hence, nuclear function and morphology depend on the proper communication via ER-NE junctions. However, the biogenesis, architecture and maintenance of ER-NE junctions have remained elusive.We have recently found that ER-NE junctions exhibit a narrow and constricted ultrastructure during the cell cycle in mammalian cells. These observations led us to postulate that ER-NE junctions are formed and maintained by specific membrane-shaping proteins that are crucial for nuclear function. Here, we propose to identify the molecular mechanism that governs the structure and function of ER-NE junctions. We will provide a quantitative and dynamic high-resolution view of these enigmatic structures by combining time-resolved electron microscopy and quantitative live imaging with molecular perturbations. Using these datasets, we aim to develop a mechanistic model of how ER-NE junctions form and contribute to nuclear function.The NE proteins supplied via ER-NE junctions have critical roles in gene expression, nuclear organization, and nuclear pore biogenesis, as wel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Switching Technologies for Optically Labeled Signals' (STOLAS).

assistant: **Concept**

The STOLAS project proposes novel stacked optical labelling techniques enabling optical bypassing of electrical IP routers, in order to improve the throughput of packet-switched IP-over-WDM networks. While the data payload is modulated on the intensity of an optical carrier, the wavelength of the signal is assigned as the first optical label level; the second label level is modulated orthogonally to the data, by DPSK (or FSK) modulating the carrier. Network and node architectures will be compared regarding performance and costs. Also the physical layer behaviour will be analysed. Key optical components and modules will be made: fast modulatable widely tunable optical transmitters, optical stacked-label swapper, label-controlled optical cross connect and add/drop node, and multi-wavelength 2R regenerator. The modules will be integrated in a laboratory testbed and in a field trial jointly with two running IST projects. OBJECTIVESThe main objective is to improve the throughput of packet-switched networks by novel optical routing techniques based on stacked optical labels; supported by:- to evaluate the network possibilities of optical label switching theoretically- to demonstrate high-speed modulation and fast wavelength switching of widely tunable lasers- to develop multi-channel 2R regenerators in a hybrid technology- to develop optical-label-controlled cross connect and add/drop nodes- to study monitoring and control aspects of optical-label-routed networks- to build a limited network testbed and to validate the key functionalities in a laboratory testbed and in a field trial- to contribute to standardisation processes.DESCRIPTION OF WORKThe activities are organised in four workpackages:- in WP1 System and Network Architecture, the requirements put on a high-throughput
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'INtegrated HEart Research In TrANslational genetics of dilated Cardiomyopathies in Europe' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Inherited dilated cardiomyopathies (DCM) are monogenic disorders caused by mutations in more than 30 genes, characterised by substantial phenotype heterogeneity. DCM affects 1:2.500 individuals and is the major cause of heart transplantation and death for non-ischaemic heart failure in adolescents and young adults. Currently, less than 1% of patients with familial DCM are genotyped in Europe. The INHERITANCE (INtegrated HEart Research In TrANslational genetics of dilated Cardiomyopathies in Europe) consortium propose to investigate over 2,000 existing DCM patients and their relatives in order to translate novel insights on the aetiology and pathophysiology of inherited cardiomyopathies into innovative disease specific diagnostic and treatment strategies. The consortium members share common clinical, scientific and ethical standards with respect to patient care and family screening, and have individual expertise in the clinical management and molecular genetics of inherited cardiomyopathies. The INHERITANCE strategy is to integrate genomic, proteomic, structural and functional studies exploring the molecular cascades arising from causative mutations with innovative clinical assessments in order to understand disease expression, evolution and to explore novel therapeutic strategies both in humans and in animal models. The immediate benefits will include preclinical and presymptomatic diagnosis, family-tailored clinical work-up, optimisation of existing treatment strategies and cost-effective use of medical resources. In the medium term, these studies will catalyse the development of new disease specific protocols, and will provide a model for the exploration of ground-breaking genetic and pharmacological therapies.