RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative sediment management framework for a SUstainNable DANube black SEa system' (SUNDANSE) targeting Horizon Europe.

assistant: **Abstract**

The Danube River has played a vital role in supporting both human and animal life for centuries. Since the late 19th century, human interventions have significantly altered the natural flow of the river to optimize its utility. These interventions have included actions such as straightening the riverbed, constructing hydropower plants, collecting freshwater, establishing nuclear power plants, engaging in agriculture, and facilitating navigation. The combined effects of climate change and extensive river regulation have led to a significant disruption in the natural balance of sediment in the Danube River, increasing flood risks, altering hydropower production, decreasing navigability of the river, and affecting in biodiversity within the Danube Basin.SUNDANSE will:•carry out a conceptual Driver-Pressure-State-Impact-Response with multiple levels of analysis (catchment level, water body level, etc.) to understand and address environmental issues of the uniqueness of Danube river lighthouse•realize maps for observation of critical points for excessive sedimentation and/or excessive erosion, sediment transport and flow restoration•perform innovative actions of measurements using cutting-edge portable on-vessel equipment prototypes for the direct analysis of microplastics and toxicity•achieve an advance numerical prediction model of sediment transport process in the Danube River basin, to have a comprehensive overview of river dynamics•develop an Innovative Sediment Management Framework for enhanced and sustainable sediment management within the Danube River basin•produce an Action plan and Roadmap for associated regions to upscale demonstrated sustainable and effective solutions for sediment management•fulfil interconnections synergies with DanubeSediment and SIMONA projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DLC and CVD diamond coated Si3N4 ceramics for tribological and biomedical purposes' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The goal of the project is the development and application of highly adherent CVD diamond (in polycrystalline and nanocrystalline NCD- forms) and diamond like carbon (DLC) coatings on compatible Si3N4 materials.This ceramic presents a close thermal expansion coefficient to that of diamond, reducing the thermal stresses at the interface, promoting high adhesion strength. CVD diamond/Si3N4 and DLC/Si3N4 materials have a high application potential, its use as biomaterial for surgical implants and medical dev ices being emphasized.The standard artificial joints are constituted by the UHMWPE/metal bio-tribological system that can be advantageously replaced by smooth DLC or NCD/Si3N4 bio-tribosystems.This is made by coating a bioactive tough ceramic that enters into the bone, with an ultra-hard biocompatible film with outstanding wear and corrosion resistance. The absence of metallic wear eradicates metallosis. Simultaneously, the reduction of UHMWPE wear will diminish the implant failure probability.Also, the production of diamond/Si3N4 medical devices for odontologic, orthopaedic and surgical uses, anticipates extended lifetime and resistance to sterilisation procedures. Si3N4 samples are diamond coated by both the microwave plasma chemical vapour deposition ( MPCVD) technique for flat specimens and hot filament (HFCVD) method for complex geometries.The DLC films are grown by DC or RF magnetron sputtering. Further experiments dealing with friction and wear behaviour of CVD diamond aim the development of dry-running machine elements and metalworking tools that require no pollutant lubrication, with evident environmental benefits.As cutting tools, CVD diamond/Si3N4 inserts are tested in turning operations with real-time acquisition of cutting forces by dynamometry. The cuttin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamics and composition of filamentous micro-organism communities in industrial water systems' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Filamentous microorganisms cause bulking sludge resulting in major problems in industrial wastewater treatment plants (Wets). Development of prevention strategies is hampered by lack of identification methods for these organisms. Thefilamentous biodiversity in a large number (>100) industrial water systems is explored using conventional and innovative molecular identification techniques. Filaments are micro manipulated from activated sludge and species pacific 16S rRNAsequences are derived via PCR or reverse transcripts PCR.Probes and primers for respectively Fluorescent In Site Hybridisation and PCR and multiplex quantitative are designed to monitor filament population composition and dynamics. Filamentecophysiology is studied both in pure culture and in site using microautoradio-graphy. This study will result in a methodology to study biodiversity and dynamics of filamentous microbial populations in industrial Wets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Metabolic diseases from the point of view of the gut bacterial motility and mucus barrier' to be submitted under Horizon 2020.

assistant: **Abstract**

MEDMOTILUS aims to uncover the alterations of gut mucus/microbiota homeostasis in metabolic diseases and therapeutic targets using human data and animal models. It will fill research gaps in the multiple scenarios of metabolic diseases, one of the greatest threats to human health. The gut microbiota is a key environmental factor of these diseases, and its modulation is a potential treatment. However, the host-microbiota interactions are far from being fully described. The gut mucus barrier is a host spatial control that plays a crucial role in the microbiota regulation but poorly understood. Diet and medicines may affect this defense and, thus, improving metabolism and reducing gut bacterial motility, whose increase is linked to health disorders even without serious infections. However, there is no in-depth bacterial motility characterization in metabolic diseases and no data on mucus features nor on its effect on bacteria in these diseases. So, the overall research goal of MEDMOTILUS is to provide evidence of the impact of gut bacterial motility and mucus in metabolic diseases as key factors involving dysbiosis, mucus features, and metabolic status. MEDMOTILUS takes a multidisciplinary approach. It will go beyond the current state-of-the-art by using original input data (bacterial motility from modeling and mucus features) with multi-omic approaches (also metabolomics and metagenomics). Several potential solutions acting on mucus will be assessed in mice. The use of human data already generated and animal models (mice and a new pig model) will allow me to identify robust and useful biomarkers of the gut mucus/microbiota homeostasis in metabolic diseases for further research on diagnosis and monitoring to reduce long-term complications and deaths. At the level of my car
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Origin and optical properties of inertinite. Relation to coal combustion efficiency'.

assistant: **Innovation**

During the last years, power utilities in Europe have been changing their feedstocks from indigenous coals to fuels imported from other continents. Many of these coals belong to the so called Gondwana continent and have petrographic and technological characteristics quite different of the ones of the coals of the Northern Hemisphere. These differences are mainly related to the higher proportion of 'inert' components and its reactivity. The coals, in the power stations, are not burned alone but blended in different proportions and the coal blends usually behaves different to the isolated constituents. In this context, this project is aimed to relate the optical properties of the inertinite with its reactivity in combustion processes, to asses the behaviour of the inertinite in coal blends and to establish a quick, easy and inexpensive method to determine the reactivity of the inertinite. The knowledge gained as to the influence of coal depositional setting on inertinite reactivity will provide an initial reference to estimate the inertinite reactivity of coal formed in similar conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safe Passage and Navigation' (SPAN) under Fourth Framework.

assistant: **Objectives**

The SPAN project has achieved all the objectives. It provides a sound basis for planning safe passage at high speed in shallow water and a real time aid for navigation for fast twin hulled vessels. Software tools have been developed to optimise waterjet design, based upon new proven data, providing great improvements in shallow water. A computer model has been developed through which operational limits in shallow water could be realistically examined to ensure safe passage. An onboard model-based predictive system for collision/grounding avoidance in shallow waters has also been developed, to maintain safe navigation."A new more efficient and low wash hullform has been developed. An ultra low wash hullform has also been designed for use when wash is the very most important factor.A new design for waterjets will result in lower weights of the craft and improved manoeuvrability. The excellent CFD results in comparision with the full scale trials have provided the consortium with a strong tool to further optimise the inlets for shallow water effects.The navigational aid developed under the SPAN project exceeds the original objectives of the project proposal. As far as the consortium is aware there is nothing remotely as sophisticated available outside the military aerospace industry.Objectives and content The market for fast ferries in deep water is well established. SPAN will extend this market by developing fast passenger ferries capable of operating in restricted and shallow waterways. In areas of high population density surrounding estuarine or wide river systems fast ferries provide an alternative to road transport giving economic and environmental benefits, by giving people better access to work and reducing road traffic congestion with associated fume emissions. For
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CEREBELLUM IN VISUALSPATIAL ORIENTATION' (CERVISO), addressing dissemination and exploitation.

assistant: **Impact**

The Cerebellum in visual-spatial orientation (CERVISO) is inter-disciplinary, exchange program uses original and innovative research methods to investigate the role of cerebellum in optimization of motor control and spatial orientation. Toward this objective we will identify patterns of cerebellar functions using the saccadic eye movement model. We will study visual spatial exploration in normal subjects and in patients with cerebellar damage. The impact of this research will be to provide further instruments for understanding and modelling neural substrate of cerebellar functions during visual spatial exploration, with implications for diagnosis, and rehabilitation of cerebellar patients. The proposal will be implemented combining the efforts of   three European groups and two USA groups. This will also enable researchers to be trained in technical, procedural and scientific aspects of the study by experienced organizations. Moreover this proposal will facilitate the transfer of knowledge among researchers with experience in different scientific fields and the study of rare genetic diseases clustered in specific regions. The European groups include a INSERM team of Neurologists and Neuropsychologists from Paris (France); a group of Neurologists and Bioengineering from the University of Siena (Italy); a group of Physicists from University of Iasi (Romania). The USA Groups are composed by a team of Bioengineering and Neuroscientists from Baltimore, and by a group of Neuroscientists and Bioengineers from Cleveland. This exchange program results from previous scientific and training collaborations among these groups and is projected for a sustainable long-term cooperation. The project has been selected for a Grant by the Local Institution (Regione Toscana) of Ministry for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Lignin Based Carbon Fibres for Composites' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The use of carbon fiber (CF) based composites is of growing importance in many industrial applications with the current global market estimated at $28Bn [ref 9]. However, the current high cost, limited production capability in Europe and the use of petroleum-based polyacrylonitrile (PAN) as the precursor fiber (PF) from which the CF is ultimately derived, requires the development of innovative routes to industrial production. To achieve this, novel processes are needed which can utilise sustainable precursor materials to produce CF of adequate quality, reduce energy consumption during manufacture and make CF widely available and affordable across a range of different European industrial sectors. The aim of LIBRE is to use lignin rich side streams in order to develop a more resource-efficient and sustainable carbon fiber production, based on biopolymers for PF production and energy efficient processing technologies for conversion of PF to CF which will have performance levels matching or bettering current industrial standards.


**Keywords:** Lignin, Carbon Fibre, Sustainable Manufacture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Link (legume interactive network a strong multidisciplinary scientific network for the benefit of grain legume integrated chain to meet the protein demand of the European end-use industry', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The general mission of the proposed thematic network is to link the scientists and the economic actors (growers, advisory services, industrialists, etc.) in relation with grain legume integrated chain, for overcoming the remaining constraints to meet the demand in European protein-rich materials.  LINK provides us the tools for a stronger coordination by: - identifying the priorities and gaps of production and utilisation of protein-rich seeds; - optimising the research potential on grain legumes and developing a multidisciplinary and integrated approach; - improving the transfer from laboratories to economic actors (companies, growers. etc.).  This thematic network will allow us to gain a strong European scientific identity in that area and will contribute to the efficiency of agricultural primary production and end-use industry, in accordance with the economic and agricultural CAP context. To meet these objectives, the thematic network:  - identifies limiting factors and needs of the economic actors and to stimulate information exchanges between them for joint approaches (task 1 );  - links on-going European programmes, stimulate exchanges of information between scientific experts from different disciplines, and identifying scientific gaps to fullfil in future joint scientific actions (task 2)  - stimulates an increased cohesion and communication in Task 3 to assist the interface between and within researchers and end-users, with joint brainstormings and thematic workshops (tasks) - develops joint means of communication and support means for an increased cohesion (Task 4).  An efficient Management structure is required to run the network and it is helped by the involvement of the Executive Secretariat of the AEP (European Association of Grain Legume Research), which h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular and functional characterization of novel communication pathways based on pronociceptin-derived peptides and their receptors in the nervous system' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To determine experimentally and in silico, as a prerequisite to a rational medicinal chemistry, three-dimensional models of the nociceptin-ORL1 receptor complex.-To identify and subsequently clone, as potential novel targets for therapeutic agents, specific receptors to pronociceptin-derived (orphan) neuropeptides.To firmly establish that nociceptin and pronociceptin-derived (orphan) peptides regulate nociception, and identify other functions of pathological interest.The objectives of the project are to provide a detailed molecular and functional description of novel peptide-based communication pathways that are thought to modulate pain in the nervous system. One pathway makes use of nociceptin, the recently identified natural agonist of ORL1, a Gprotein-coupled neuroreceptor closely related to opioid receptors. The other may utilize F15Q, a peptide of yet unknown receptor, which is also present as one potentially excisable copy in pronociceptin, nociceptin's precursorpolypeptide. When centrally (i.c.v.) administered in rnice, nociceptin and F15Qboth render the animals' hyperreactive to thermal nociceptive stimulation, suggesting that the two heptadecapeptides may normally act to produce orexacerbate the pain sensation. Most irnportantly then, antagonists of thenociceptin (ORL1) and/or F15Q (unknown) receptors should display analgesic activity. Molecular description: in order to provide a structural basis to the rational design of better adapted ligands, including antagonists (potential new analgesics), the functional architecture of the ORLI receptor and the structure-activity relationships of nociceptin (Noc) will be analysed by means of protein engineering (receptor) and peptide synthesis (ligand). 3-D models of the Noc-ORLl receptor complex will provide assistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'UNLOCKing next generation computer-guided  Enzyme Discovery and Design.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

ZYMVOL is start-up specialized in computer-driven biocatalyst discovery and development for the pharmaceutical and fine chemical industry. We harness the power of high-performance computing to identify and optimize custom-made biocatalysts that deliver additional value. Biocatalysts are enzymes that accelerate industrial chemical reactions and have multiple applications for the synthesis of chemical compounds. Engineered enzymes can provide improved performance, representing a unique advantage. The protein engineering market is a fast-growing business estimated to reach 2.67B€ by 2024 (CARG +15%). The main obstacle today to performance enhanced biocatalysts is that current enzyme engineering processes rely on slow and costly experimental tests with uncertain outcomes. Our in-silico engineering platform can rapidly find thousands of enzyme variants delivering reliable predictions, that allow to replace up to 90% of experimental tests, making the enzyme development cost (10-fold lower) and time (cut by 50%) effective.ZYMVOL aims to be the reference in the computer-driven enzyme engineering market and convert molecular modelling in a commodity. In addition to our virtual enzyme sales (we plan to capture €11.17M by 2022 after entering into the North American market), we will promote a royalty-based revenue model from licensing enzymes developed in-house (global enzyme market is projected to reach €9B by 2024).ZYMVOL’s founding team is composed by Maria Fátima Lucas, CEO, Emanuele Monza, CSO and Victor Gil, CTO. All members of the team hold a PhD in chemistry, physics and biomedical engineering. The Company is seeing excellent traction which has allowed it to grown organically in its first 20 months. Thanks to a services-based business model it has already reached breakeven