RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regaining control of cancer at biological borders' (BorderControl).

assistant: **Innovation**

During dissemination, cancer cells must face and overcome several physiological borders, including the immediate stroma for local invasion and the endothelium for long-distance metastasis. At these critical junctures, cell plasticity between epithelial (E) and mesenchymal (M) states could determine metastasis potential. Based on our preliminary data, ideally-positioned cues emanating from the normal stroma contain the tumour in situ. Once this first border is breached, rare cancer cell-endothelial interactions trigger further dissemination through the vascular border. Moreover, cancer cell plasticity is vital throughout this process, enabling optimal response to distinct border microenvironments.     In BorderControl, we will build on our cutting-edge cell biology expertise and close collaboration with clinicians to define the molecular signals underlying these border crossings and gain unprecedented information on how cancer cells overwhelm these natural defences. Starting with patient tissues, we will spatially profile the tumour-stroma border to identify receptor-ligand pairs that regulate invasion. We will use microfluidics to image, catch and profile cancer cell crossings at endothelial hotspots and determine key molecular regulators of the process in endothelial and cancer cells. Building on our novel discovery of endosomally regulated E-M cell states, we will test how E-M transitions impact border-breaching potential. These novel concepts will be investigated with interdisciplinary methods (scRNAseq, synthetic biology, colour barcoded HTS) and our new technologies (dynamically tuneable multicell-type migration and invasion imaging platforms) to determine the specific interactions/mechanisms regulating border crossings. Finally, we will take the molecular level di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'After the Ice: using a hybrid zone as a window into the genes underlying species formation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The process of species formation is responsible for the global distribution of biodiversity, from the generation of species in habitats as extreme as the arctic or deep-sea thermal vents, to the generations of crop varieties that are locally adapted to different water regimes. Yet, we still understand very little about which genes drive the formation of new species, and what the nature is of selection acting on these genes. Evolutionary genetic studies have traditionally used either experimental hybrids from species that rarely meet in nature, or hybrid zones in uncontrolled conditions, often leading to conflicting conclusions. Here, we integrate both approaches in a single biological system: two grasshopper subspecies that maintain ecomorphologic differentiation despite ongoing hybridization since the end of the last glaciation. First, we will use experimental hybrids to test which genes are associated with reproductive dysfunction. We then use a hybrid zone as a natural laboratory to test if those phenotypes and genes contribute for stable boundaries between the two species in nature. Finally, we use samples distributed over a time series, to test whether those genetic boundaries are stable over evolutionary time. Rooted sound in my background of field- and lab-based methods, this project brings together state of the art genomic methods championed by the Center for GeoGenetics (Denmark), and the multidisciplinary knowledge on this species accumulated by the Universidad Autónoma de Madrid (Spain). By moving from lab to nature and through time, this integrative framework will not only provide unique insights on the field of speciation, but will provide a transferable framework that is applicable to emergent challenges of the modern society, such as identifying genes ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High added value materials from waste tyre gasification residues' (TYGRE) under Seventh Framework.

assistant: **Objectives**

This project is focused on the waste tyres recycling and promotes a thermal process mainly devoted to the production of ceramic materials. The disposal of waste tyres represents a relevant problem within the waste management strategy of the European Community and, despite the attempts of reusing waste tyre in many different ways, a relevant fraction (nearly 23%) is still landfilled. Pyrolysis and gasification are a promising way for alternative high-efficiency material and energy production, since both the processes provide a gaseous and a liquid fraction easily usable as fuels or chemical sources. Nevertheless, besides these encouraging preliminary remarks, the experiences on both pilot and industrial scale have shown that without a valuable exploitation of the solid by-product (char), the whole economic balance of the process is not advantageous and therefore the process is not sustainable. The gasification/pyrolysis treatment of waste tyres, apart from a high hydrogen rich syngas, brings to a very high carbon-rich char fraction, which has been tested in the past as a semi-reinforcing filler for new tyres or as an active carbon. Nevertheless, despite the recent technological advances, it is still unclear whether there is a market demand for this product. On these bases, the main idea of the proposal consists in redirecting the gasification process towards the material recycling, by coupling a second thermal process, dedicated to the plasma synthesis of silicon carbide, to the preliminary waste tyres gasification. The overall strategy of the project’s workplan mainly consists of three levels: a.the development of a sustainable recycling process for the waste tyre treatments, with the final construction of a prototype plant; b.the sustainability assessment, in terms of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of first trimester doppler assessment of fetal ductus venosus flow in screening for aneuploidy and congenital heart disease' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The applicant is expected to improve his capabilities in planning and managing a large-scale clinical research project in fetal medicine. In particular, besides refining his skills in fetal ultrasound, he will be expected to assess the role of a new diagnostic tool in a logical and stepwise sequence starting from standardisation of the method and verification of its intra-and inter-observer variability, through definition of reference values, its inclusion in a multivariate analysis of risk, ending with its definite application to fetal aneuploidy and heart; defects screening programmes. The participation into the project will allow the applicant to be proficient in all these aspects of clinical research, and to reach a high level of quality and experience in fetal medicine research. The host institution will take advantage from the collaboration of a young researcher already experienced in the techniques involved in this study and dedicated full-time to the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Cost-effective renewable energy for rural and peri urban areas in the Mediterranean region'.

assistant: **Concept**

The objectives of the MEDRES research are to assess the opportunities for cost-effective renewable energies (RE) for rural areas and villages, the real effectiveness of new technologies through better knowledge of end user acceptability for energy efficient technologies and practices and to measure the impact of electrification on socio-economic development in rural areas.The main results will be elaborated in a set of recommendations and proposed adapted strategies to be disseminated in the region. The countries will be studied in order to promote cost-effective RE for rural areas in the region and best practices in order to enhance sustainable development, which is in line with the MDGs, the outcome of the International Conference on Renewable Energies in Bonn 2004 and the EU strategy within its neighbouring countries.The proposal is structured along five main work programmes and related deliverables:Analysis of the present RE context in the Southern Mediterranean countries and prospects;Research on sustainable power for rural areas and villages;Analysis of energy efficient use in peri-urban and rural areas, technologies and practices effectiveness;Measuring the impact of electrification on socio-economic development in rural areas and Management,Exploitation and dissemination.The research will support the decision makers in these countries to better define the best practices of sustainable energy in the rural and peri-urban areas and especially regarding RE and energy efficient technologies. It w ill also serve to support the EC with respect to the formulation of future INCO programmes focussing on the thematic issue of Sustainable Energy as well as to elaborate draft concepts for Renewable Energy projects which may be supported by the EC and the Mediterranean Countr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Automatic Synthesis of Software Verification Tools from Proof Rules'.

assistant: **Objectives**

Software complexity is growing, so is the demand for software verification.  Soon, perhaps within a decade, wide deployment of software verification tools will be indispensable or even mandatory to ensure software reliability in a large number of application domains, including but not restricted to safety and security critical systems.  To adequately respond to the demand we need to eliminate tedious aspects of software verifier development, while providing support for the accomplishment of creative aspects.  We believe that the next generation of software verifiers will be constructed from logical specifications designed by quality/verification engineers with expertise in the application domain.  Give a specification describing a verification method, a corresponding software verifier will be obtained by implementing a frontend that translates software source code into constraints according to the specification and then coupling the frontend with a highly-tuned general-purpose constraint solver, thus eliminating the need for algorithmic implementation efforts from the ground up.  This project proposes the necessary methodology, solving algorithms, and tools for building verifiers of the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cancer Vaccines and Gut Microbiome: a rational approach to optimize  cancer immunotherapy' in the context of a Horizon 2020 call.

assistant: **Objectives**

This proposal intends to shed light on the interplay between cancer immunity and gut microbiome as a way to optimize personalized cancer vaccines and immunotherapy. The project originates from two milestone discoveries. First, to be effective cancer immunotherapies have to target CD4+/CD8+ T cell neo-epitopes, which originate from tumor mutations. Second, the gut microbiome influences the effectiveness of anti-PD-1/PD-L1 antibody immunotherapy both in animal models and in humans. We also recently showed in a mouse model that oral gavages with Bifidobacterial cocktails improved the therapeutic power of neo-epitope-based cancer vaccines. How microbiome affects anti-cancer immunity has not been fully elucidated yet and a deep understanding of the underlying mechanisms has the potential to substantially improve cancer immunotherapy. Since microbiome antigens are processed and presented by antigen-presenting cells and microbiome-induced T cells represent large fraction of the peripheral T cell repertoire, our hypothesis is that this large repertoire includes T cells which cross-react with cancer neo-epitopes (“molecular mimicry (MM)”). Depending upon the composition of gut microbiome, cross-reacting T cells can positively or negatively modulate anti-tumor immunity.  To demonstrate the role of MM in cancer immunity this project intends (i) to select the cross-reactive T cell epitopes as predicted by meta-omics analysis of gut microbiome and exome/transcriptome analysis of cancer cell lines, (ii) to formulate vaccines containing different combination of cross-reactive epitopes, and (iii) to test vaccine anti-tumor activities in normal mice, gnotobiotic mice and mice with engineered microbiome. The ultimate goals are: 1) to provide new criteria for neo-epitope selection in pers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SEPARATION METHODS FOR CLOSED-LOOP TECHNOLOGY IN BLEACHED KRAFT PULP MANUFACTURE' (SMCLT) targeting Fourth Framework.

assistant: **Abstract**

The pulp and paper industry has a great potential to develop its operation into atruly ecocyclic production system. A higher degree of system closure of thepulping process leads to problems due to the accumulation of different substances. It is therefore necessary to introduce internal separation techniques which clean theliquid flow in the mill. Another issue of great importance is to solve the waterbalance in an reasonable way which means reuse of evaporator condensates. Theoverall objective in this project proposal is by new separation techniques findsolutions to 'bottlenecks' earlier identified in closed-loop manufacture of bleachedchemical pulp. The reach the main objective, the project is divided into four partswith their corresponding objectives :1. Reuse of condensates from the black liquor evaporation : Condensates from the black liquor evaporation have to be reused in a closed-loop process. The smell is a critical parameter in products used in food packages. Bad smell in process water can be transferred to pulp and paper. Consequently, the black liquor condensates need further treatment to remove the smell-creating substances. We intend to develop methods to produce washing water from condensates for use in the bleach plant when filtrates are recycled.2. Handling of accumulating inorganic elements : Inorganic non-process elements, NPE's, will accumulate in a closed-loop process and cause very severe negative effects such as scale, deposits, high content of inerts in lime cycle and negative effects in TCF-bleaching. NPE's such as Al, Si, P, Ca, Ba, Mn, etc can today only be purged in very limited ways or not sufficiently effective. We suggest a technology which enables these elements to be purged in a precipitation/separation-step from a flow of acidic or neutr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sharing KnowledgE Assets: InteRegionally Cohesive NeigHborhoods' in the context of a Seventh Framework call.

assistant: **Objectives**

The EU has experienced successive enlargements in recent years with the incorporation of new countries. These have changed the EU map, broadening frontiers and thus appearing new neighbouring countries. The integration of them offers new opportunities but also implies some risks. Even though the ENP has demonstrated to be an integration tool, which has provided an effective and clear framework to establish cooperation links within neighbouring countries, some are important areas with considerable potential for further progress. SEARCH will focus attention on some areas which so far have been neglected in the analysis of the impact of the ENP but which are of central interest in the economic literature on cohesion. Divided in 8 WPs. WP1 will obtain a background framework. From WP2 to WP5, scientific research will be carried out analyzing different aspects that ENP should strengthen in the future. WP6 will collect and analyse the policy implications from previous research. WP7 will communicate the research results and the policy recommendations through the correct communication channels to the potential users. WP8 will ensure the coordination of the SEARCH project consortium work with the previous experience of UB-AQR. It includes a remarkable well-balanced consortium with partners from 16 different countries, different backgrounds and expertise, giving an extensive vision to focus adequately to the project’s objective of identifying policies that will strengthen the relationship between the EU and the NCs. Main impacts will be the advance on the research on ENP state of the art, obtaining relevant results for contributing to the formulation of future ENP, the involvement of relevant communities, stakeholders and practitioners in ENP research, the critical mass of resourc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Division of Labour and the Evolution of Complexity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Division of labour is fundamental to the evolution of life on earth, allowing genes to work together to form genomes, cells to build organisms, pathogens to escape immune attack, and eusocial insect societies to achieve ecological dominance. Consequently, if we want to understand how life on earth evolved, we need to understand why division of labour does or, just as importantly, does not evolve.  There are two major outstanding problems for our understanding of division of labour: First, how can we explain why division of labour has evolved with some traits, in some species, but not others? Given the potential benefits of dividing labour, why does it not arise more frequently in cooperative species? Second, in cases where division of labour has evolved, how can we explain the form that it takes? Why do factors such as the degree of specialisation, or mechanism used to produce different phenotypes, vary across species?  I will combine my social evolution expertise with novel synthetic and genomic approaches to address these problems. I will explain the distribution and form of division of labour in the natural world, with an interdisciplinary research programme, divided into four work packages: (1) I will provide the first experimental test of the fundamental assumption that division of labour provides an efficiency benefit, by synthetically manipulating bacteria. (2) I will test how selection has acted for and against the evolution of division of labour in natural populations of bacteria, using novel genomic analysis techniques. (3) I will determine why division of labour evolved in some species, but not others, with an across species study on insects, and experimental evolution of bacteria. (4) I will establish a new field of research on why different species use diff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Pharmacoepigenetics for precision medicine in type 2 diabetes' (Proceed), addressing dissemination and exploitation.

assistant: **Impact**

The prevalence of diabetes will rise to ~592 million in 2035. Type 2 diabetes (T2D) is a leading cause of death through its vascular complications. High glucose increases the risk for complications, and thereby suffering for patients and costs for society. It is important that patients with T2D receive an optimal therapy that lowers blood glucose. Metformin is first-line T2D therapy. However, ~30% of patients do not respond to metformin. Currently, there are no biomarkers that predict the response to metformin. We discovered blood-based epigenetic markers that could discriminate between responders/non-responders to metformin in drug-naïve patients with T2D. This epigenetic tool may be further developed to help patients with T2D receive an optimal therapy. The aim of PROCEED is therefore to develop and commercialize our pharmacoepigenetic tool. We expect this biomarker tool to aid clinical decision-making in T2D therapy.