RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Energy Systems Engineering' (ESE).

assistant: **Innovation**

The main idea of the ESE proposed project is to exchange and transfer knowledge between 3 European Research groups (Imperial College - UK, University of Pannonia - Hungary and Aristotle University of Thessaloniki, Greece) and 3 distinguished and top university groups from China (Tsinghua University and Fudan University) and Korea (Yonsei University). The selected groups are leaders in the energy systems engineering field and working following different approaches and for different industrial case studies. Thus, the ESE proposed project will practically implement its programme through the following main activities:(i) Short-term secondments (2-6 months) of 86 researcher months from EU research groups and82 researchers months from the Chinese and Korean partners (WP1). A well balanced schemeof both Early-stage (PhD students) and experienced researchers will participate in the exchanges.(ii)  Short-term selected research projects covering a range of challenging energy systems engineering problems which will provide the basis for the transfer of knowledge activities (WP2)(iii) Organisation and implementation of a well-structured training programme including trainingscourses, seminars, workshops and summer schools open to external and industrial participants(WP3).(iv) A well structured dissemination and exploitation plan including joint publications in peerreviewed international journals, joint conference presentations, presentation to the industrial partners of the consortium, and a web portal to facilitate internal communication other dissemination activities (WP4).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Landscape of Resistance. Science, power, and environmental justice in the struggle over garbage and incinerators in contemporary Naples, Italy'.

assistant: **Innovation**

“LaRes” aims to establish the applicant as an international expert and leader on the theory of socio-ecological conflicts in European societies and its application to the environmental governance of hazards and waste. Training will consist of attendance at selected courses and seminars, tutoring and joint research work with the originator of the theory “environmentalism of the poor”, Prof. J. Martinez Alier, at ICTA. During the fellowship the researcher will work on improving the theory of environmental justice and using as a case study the struggle over garbage in contemporary Naples will develop a model for the analysis of complex conflicting situations in Europe. The applicant will examine the policy implications of his research and linked them to on-going debates on EU environmental governance, with special focus on waste disposal and the location of hazards. The project will contribute to introduce/reinforce environmental history and political ecology into European research, aiming to develop a network of scholars on ecological conflicts and environmental governance studies, thus promoting scientific excellence in the European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural and mechanistic basis of MICAL regulation' to be submitted under Horizon 2020.

assistant: **Abstract**

MICALs are a family of redox enzymes that directly bind and disassemble actin filaments. An increasing body of evidence in recent years indicates that MICALs play essential roles in many tissues for myriad activities requiring discrete changes in the cytoskeleton, including axon guidance, cell morphology, synaptogenesis and neuronal plasticity. MICALs are a component of classical signalling pathways and are best known as effectors for semaphorin-plexin signalling. Although the field has made enormous advances in understanding MICAL function at the level of genetic and cellular experiments, our knowledge of the molecular-level mechanisms of MICAL signalling in cytoskeletal dynamics remains poorly understood.The overarching aim of this proposal is to understand the molecular mechanisms underlying MICAL signalling. I aim to address two fundamental and long-standing questions: (1) How do MICAL proteins precisely turn their activity on and off? (2) How do cytoplasmic segments of plexins pass the signal on to MICALs and what mechanisms control signalling? I will use a hybrid approach integrating single particle cryoEM with high-resolution X-ray crystallography to determine the overall architecture of MICAL and to elucidate molecular mechanisms of MICAL autoinhibition. In parallel, I will aim to determine the high-resolution structure of MICAL in complex with plexin to dissect molecular mechanisms of MICAL activation.All previous attempts to tease out the mechanisms governing MICAL signalling failed because full-length MICAL is expressed at a relatively low level in many expression systems. The project will greatly benefit from my previously developed protocol describing the production of MICALs in milligram quantities. Our findings will reveal fundamental principles of MICAL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Research on effective cod stock recovery measures' (RECOVERY).

assistant: **Innovation**

This proposal addresses the current critical level of the cod stock in the North Sea and the Irish Sea in support of the EU Cod Recovery Plan. The objective is to develop novel species-selective gear prototypes for the three mixed-species demersal trawl in the North Sea and Irish Sea fisheries with the highest level of cod discard, e.g. otter trawling, beam trawling and Nephrops trawling.A total of seven institutes work together involving gear technology, fisheries biology and fish behaviour input. The project duration is 38 months. It consists of four work packages, organised in the Task Groups: Co-ordination, and Gear Development. Collaboration with the fishing industry (associations and netmakers) is foreseen.ObjectivesThe Cod stocks in some European waters are at critical survival levels. Consequently the European Commission has issued a emergency plan for North Sea cod in 2001 and has also developed a rebuilding plan for cod and hake (COM 2001 (326)).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Constructing polar rotors in metal-organic frameworks for memories and energy harvesting' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

I seek to develop new ferroelectrics based on metal-organic frameworks with dipolar rotors. Ferroelectrics are targeted to be used as physically flexible memories and mechanical energy harvesters for biocompatible sensors and implantable monitoring devices. As ferroelectrics can store and switch their polarity, they can be used as memories. Via the piezoelectric effect, they can harvest mechanical vibrations. The materials most compatible with flexible substrates, are soft matter materials. However, these so far don’t meet the requirements. Especially lacking is a combination of  i) polarisation stability, ii) a sufficiently low energy barrier for polarisation switching and iii) fast switching. As energy harvesters, soft matter materials are hampered by low piezoelectric coefficients.The main objective of this proposal is rational design of ferroelectrics by obtaining a fundamental understanding of the relation between structure and properties. I will achieve this by uniquely synthesizing polar rotors into 3D crystalline scaffolds that allow to alter the rotors’  nano-environement. I will achieve this via polar ligands in metal-organic frameworks (MOFs). The variability of MOFs allows to tune the nature of the hindrance towards rotation of the polar rotors. The tuneable flexibility allows to regulate the energy harvesting efficiency. Moreover, MOFs have already shown potential as biocompatible materials that can be integrated on physically flexible substrates. The research consists of i) synthesis of polar rotor MOFs with targeted variations, ii) reliable characterisation and computational modelling of the electronic properties, iii) nanoscopic insight in the switching dynamics. The approach allows to understand how ferro- and piezoelectricity are related to the materia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Non-standard data and image processing - from nonlinear Optics to Quantum computing' (OptiQ).

assistant: **Concept**

The OptiQ project is focused on non-standard data and image processing methods which will lead to advances in quantum computing (QC). The project is designed as a platform for collaboration of academia (Silesian University of Technology in Poland), research (Austrian Institute of Technology and Security Business Austria) and industry (Boson Energy from Luxemburg, LG Nexera from Vienna, and Envelo from Warsaw) in a common purpose to achieve beyond state-of-the-art progress in applications of quantum optics phenomena for quantum communication and computation, in particular for quantum image processing and security. The deployment potential of these latter applications will be exploited by Boson Energy in green energy sector and by Envelo in digital secure communication, respectively. Through common implementation of an ambitious research programme, the project will generate novel skills for all consortium participants. Interdisciplinary and intersectoral staff training will serve as a basis for technology transfer and knowledge sharing between participants leading to elaboration and implementation of desired solutions. In this way, the project will strengthen collaboration between Beneficiaries in quantum computing and communication (QCC) and in optical image processing (OIP). In particular, the Consortium will focus on technology of entangled photons production and its application to Qbit building, quantum security, quantum block-chain technology and quantum communication. To facilitate contact with quantum optics, an Augmented Reality aided simulator & designer of optical quantum setups will be also developed. Particular attention will be paid to wide and efficient dissemination and communication. Due to these measures, OptiQ project will strengthen career perspectives
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A CEllulaR immunoTherapy virtuAl twin for personalIsed cancer treatmeNT'.

assistant: **Objectives**

This project aims to create a multi-scale patient-specific human virtual twin for patients who are eligible for CAR T cell therapy, which can be extended to cellular immunotherapies in general. The virtual twin will be fully integrated into the ecosystem under the Digital Europe Programme and will be available as a research-use-only prototype in relevant application environments with technology readiness level 6. The virtual twin will support decision-making throughout the patient's journey, from diagnosis to pre-treatments, cellular immunotherapy, and late patient monitoring. This will enable patients and health experts to identify the most effective course of therapy.The virtual twin for cellular immunotherapies will take multi-scale modelling to the next level by providing methodological concepts for integrating ""living drugs"" such as CAR T cells into the human virtual twin ecosystem.To achieve this goal, the project builds on existing data models for hematological malignancies and multiple myeloma (MM) to create a virtual twin for CAR T cell therapy for MM patients. The implementation process follows software development principles for software as medical devices, ensuring the exploitation of the research-use-only prototype. Patient's, SSH, gender differences, and other stakeholders' perspectives are fully integrated into the design, specification, and implementation process.Throughout the implementation process, a modular software architecture and extensible ontologies/terminologies are utilized, making the reference model easily transferable to other indications that can be treated with CAR T cell therapy or other cellular immunotherapies. Overall, the CERTAINTY virtual twin will provide decision support for patients and health experts, improving the effectivene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DISTRIBUTED FUNCTIONAL BRAIN NETWORKS MAPPING VIA OPTOGENETIC FMRI' (2007-2013) under Seventh Framework.

assistant: **Objectives**

A fundamental question in neuroscience is whether we can causally link distinct patterns of defined circuit elements with behavior. A mechanistic understanding of patterned activity will take into account the individual neurons and their synaptic interactions within distributed networks spanning multiple regions. We propose here to use genetically targeted switches of pyramidal neurons and whole-brain functional imaging to study the dynamics of distributed functional networks. Recent work has revealed that optogenetic strategies, using activation of channelrhodopsin-2 (ChR2), a light-gated cation channel, can be employed to drive the functional magnetic resonance imaging (fMRI) blood oxygenation-level dependent response in the rodent. Leveraging optogenetic fMRI we have shown that fMRI tracks optically evoked neural activity; further, we as well as others have shown that activity is observed locally and downstream of the light activated target. In this proposal we will use whole-brain high-resolution fMRI in awake mice combined with optogenetic activation (ChR2) of pyramidal neurons to assess the impact of causal manipulations on distributed brain network responses. Specifically, we will use the barrel field in primary somatosensory cortex (SI) to study the functional-anatomy of the mystacial vibrissa somatosensory system. We will focus on the following issues: (1) Examine whether optically-driven SI activity can be used to reveal somatotopic organization in regions connected to SI; (2) Examine the brain-wide functional-anatomy of SI optically driven activity by characterizing fMRI responses in relation to anatomical connections and neural plasticity; (3) Use regions identified with optically driven fMRI responses to focus our electrophysiological and anatomical experim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biodiversity loss mitigation and adaptation measures: Policies Governance and tools to foster transformative change' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The world is losing its wild species and ecosystems at an alarming rate, and Europe is no exception. Yet, biodiversity is the basis for functioning ecosystems, which provide essential goods and services for humans and all other life forms on Earth. We must therefore reverse the trend of BD loss in the foreseeable future, especially by addressing underlying, indirect drivers of biodiversity loss such as consumption patterns, norms and values to achieve double decoupling (of consumption from excessive natural resource use, of satisfaction from consumption). Such transformative change requires social innovation and improved, systemic governance approaches. Additionally, digitalisation and emerging technologies offer potential to support the conservation of biodiversity, increase society well-being and economic prosperity which should be harnessed while reducing their equally existing negative impacts. GoDigiBios aims to support biodiversity-relevant transformative change towards a nature-positive economy and society that will use new digital and other emerging technologies in ways that assist in reversing BD loss. Specifically, GoDigiBioS will deliver i) comprehensive understanding complemented by new insights and operational knowledge of the interactions between biodiversity, social and economic well-being, and technological development, ii) tools to support biodiversity-relevant decision-making, iii) improved, systemic policy mixes and governance approaches. To co-produce these knowledge, tools, and governance approaches, GoDigiBioS will bring together and leverage the knowledge and experience of both researchers and stakeholders from four peri-urban transformation lab regions across Europe and use specific approaches to ensure scalability and replicability of its soluti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'From Knowledge to Innovation: Building the evidence base to inform innovative entrepreneurship and risk-finance policies' (KNOWINN) targeting Horizon 2020.

assistant: **Abstract**

This project aims at achieving the following two main objectives:1.Providing new evidence on the role of public research institutions in fostering innovative entrepreneurship; and,2.Providing new evidence on the role of national policies and framework conditions in catalysing the translation of scientific knowledge into innovative entrepreneurship. The OECD will use innovative data sources and statistical techniques to provide an unprecedented portrait of innovative start-ups and VC investments across countries and sectors (Breschi, Lassébie, and Menon, 2018). Building on previous work, as well on additional data sources on e.g. intellectual property (IP) rights and on national policies (e.g. from the STIP Compass database), the OECD is distinctively positioned to deliver on the two main objectives of the project illustrated below.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Social inequalities in population health: integrating evidence from longitudinal, family-based and genetically informed data'.

assistant: **Objectives**

Social inequalities in health are observed in all societies. These inequalities have grown markedly over the past 30 years, with those in less advantaged social positions currently expected to live 5–10 years less than those in more advantaged positions. The study aims to establish the root causes of these inequalities by (1) assessing the drivers of long-term changes in health inequalities and establishing the contribution of family factors and macro-level social and economic conditions to these changes; (2) examining multigenerational interdependencies of social position and health in up to four generations; (3) estimating the causal effects of social position on health by employing molecular genetic information and assessing whether genetic associations are mediated or modified by social position; (4) evaluating the generalisability of explanations of social inequalities in health through international comparative research. The study will integrate research scattered in multiple disciplines by establishing how family background – both social as experienced through living conditions and social resources in families, and genetic as inherited from biological parents – affects health and social disadvantage within and across generations. The project will go beyond standard observational research through new conceptual insight and by using a unique combination of longitudinal register-based and genetically informed data sources. We will take advantage of natural experiments – educational and alcohol policy reforms and rapid economic changes – to identify pivotal social processes in the production of health inequalities. Our results will be ground-breaking because we will establish how family and genetic factors are intertwined with individual social characteristics and ho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of economic one-step flue-gas cleaning technology for small combustion units' (1994-1998).

assistant: **Concept**

The scientific and technical objectives of this research proposal aim to develop a compact flue gas cleaning system to purify off-gases from small combustion units in a cost-efficient one-step reactor. Research is required to formulate a suitable granulate for sorption of particles and gaseous pollutants and to connect the reactor with the combustion chamber. Field operations have to prove the suitability of the whole system. Correlations between raw gas components and operational parameters of the reactor have to be established.