RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Electronic CoMmerce Leveraging Network for Developing European Regions', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

e-MINDER will fill the gap in Europe between most and least developed regions in the field of e-commerce. The project is addressed mainly to SMEs, the basis of not developed areas, through the creation of a centre of competence in each of the participating regions. This structure will enable, observe and animate the application and development of e-commerce, encouraging the incorporation of SMEs.OBJECTIVESThe overall objective of the project is to fight the existing gap in Europe between the most and least developed regions as far as the use and development of e-commerce is concerned. Within this main frame, the specific objectives of e-MINDER will be:- To raise awareness both in the SMEs sector and within the education and training structures about the use of ICT and its application to the field of e-commerce;- To provide citizens and companies with the required service and support to implement their e-commerce related activities. To achieve all this, a European Network of three Leveraging Centres will be created among the three partner regions.DESCRIPTION OF WORKThe work to be developed within this project, in order to reach the above-mentioned objectives, will be organised in 5 different work packages: Work package 0 is dedicated to the project management and it is essential for a good running of the project. The project management will be split between the political, socio-economical and technical forces, which are needed for this challenge. Political because this project requires the involvement of the regional authorities. Socio-economical because of the numerous consequences this project implies by itself. Technical because it intends to get closer and closer to the state-of-the-art. Work package 1 is designed to assess the situation and to elaborate the key issu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mechanisms of immune surveillance of senescent cells'.

assistant: **Concept**

Cellular senescence, a stable form of cell cycle arrest, is a mechanism limiting the proliferative potential of cells. Recent studies demonstrate that cellular senescence imposes a potent barrier to tumorigenesis and contributes to the cytotoxicity of certain anticancer agents. In addition to sites of persistent damage and precancerous lesions, senescent cells have also been observed in tissues of aged individuals and can contribute to decline of tissue function with age. Therefore, mechanisms responsible for control over presence of senescent cells play central role in cancer prevention and aging. In my post-doctoral training I was first to demonstrate that cellular senescence protects against liver fibrosis, and that senescent cells can be cleared by the innate immune system to insure return to the pre-damage state. Components of the innate immune system, macrophages and NK cells were also demonstrated to clear senescent cell from tumors. However, molecular mechanisms of the recognition and the killing of senescent cells remain to be understood. Therefore, I propose to study contribution of NK cells and macrophages to recognition and elimination of senescent cells. Molecular mechanisms responsible for these interactions will be studied using engineered cell lines were senescence can be induced. Elaborate short hairpin RNA techniques will allow discovery of genes in senescent cells that are responsible for signaling to immune cells from one side, and from the other side identification of molecules in immune cells that can contribute to senescent cell elimination. Uncovering the mechanisms of interaction of senescent cells with the immune system will reveal the role of these interactions in diseases and aging and might ultimately lead to development of novel treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Recursive and Exact New Quantum Theory' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The overarching goal of ReNewQuantum is to renew the mathematical foundation behind quantum phenomena.We aim to construct a recursive and exact new approach to quantum theory. Quantum theory is one of the pillars of modern science. Its success stretches from elementary quantum mechanical models, developed a century ago by quantization of classical mechanics, to advanced quantum field theories such as the standard model of particle physics, which is the quantization of a gauge theory. However, a precise and universal mathematical formulation of the quantization procedure is still lacking. In addition, there are very few analytic methods in Quantum Mechanics and in Quantum Field Theory. They are typically based on approximation schemes which often lead to quantitative and even qualitative failures in our descriptions.In response to these shortcomings, the main objective of ReNewQuantum is to construct a completely newmathematical approach to quantization and to quantum systems. This quantum theory will provide:- a global, explicit and recursive description of the series of quantum corrections,- access to exact quantum regimes beyond perturbation theory,- a well founded mathematical theory underlying the quantization procedure, based on geometric structures,and applicable to quantum field theory and string theory.ReNewQuantum will take the lead among the world scientific community in building this new theory ofquantum physics. The researchers behind ReNewQuantum have already made important contributions alongthese directions. The construction of a recursive and exact new approach to quantum theory with the statedproperties will only be possible through their joint synergetic effort and a combination of their deep mathematicaland physical expertises, including geometry, top
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MACARONIGHT 2022 - 2023: The Researchers' Night of the Macaronesia', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Macaronesia is a biogeographical region of five archipelagos in the Atlantic Ocean of which four are inhabited: Azores (Portugal), Canarias (Spain), Madeira (Portugal) and Cape Verde (Cabo Verde). These islands share common geographical traits and similar challenges with regards to climate change, environmental degradation and loss of biodiversity. The Canary Islands, Madeira and the Azores are part of the European Union (EU Outermost Regions). The overall objective of this project is to organise a shared Researchers' Night for the Macaronesia Region for the fifth and sixth consecutive year connecting the population of these remote islands under the umbrella of the universal language of science. For these two new editions, MACARONIGHT IV aims at further widening public awareness towards science, research and innovation, especially in areas where the Region faces global challenges, such as those identified in the Horizon Europe Missions. The aim is to reach out to the population in general yet keeping specific focus on teenagers and young parents with kids in particular. The project will deploy an enhanced social-media strategy that aims to engage with citizens of different ages in their own words through their daily used channels. Activities will cover 16 islands with the ""main"" activities organised at 4 locations: Tenerife (La Laguna), Gran Canaria (Las Palmas), Madeira (Funchal), Azores (Ponta Delgada). The programmes will be organised as ""hybrid"" online/physical events that will attract 20 thousand participants in 2022 and 25 thousand participants in 2023.""


**Keywords:** Macaronesia, researchers, outermost regions, science communication, education, Horizon Europe Missions, Oceans, Green Deal, energy, climate change, biodiversity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Toward a comprehensive analysis of the dynamics and mechanisms of X chromosome inactivation in Humans' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The X chromosome is subjected to a formidable degree of concerted gene regulation, with appropriate dosage of X-linked expression in female mammals being ensured by the stable yet reversible inactivation of one of the two copies. The process of X chromosome inactivation (XCI) is critical for female development and linked to sex-specific traits and susceptibilities to various diseases. Well characterized in rodents, there is remarkably little knowledge of how XCI is articulated and controlled in humans, despite its major implication for human health. Here we propose to model in vitro the whole XCI cycle in humans to gain novel and high resolution insights into the key steps of the process and to identify critical actors and mechanisms We will exploit human embryonic stem cells and recent culture methods to mimic the early stage of development as well as more advanced organogenesis. This will allow us to investigate the four phases of XCI: (i) the steps that precede XCI (ii) its initiation, (iii) its maintenance in tissues including the hematopoietic system and intestinal organoids and (iv) its reversion in the germline. We will implement a combination of exploratory and mechanistic approaches integrating single cell analyses, CRISPR/Cas9 genome editing and genetic screens to build a comprehensive spatiotemporal map of X-chromosome activity across the human life cycle, to screen for regulators of each phase and to assess the importance of XCI and appropriate X-linked gene dosage to tissue development and homeostasis. Using an innovative set of approaches, we hope to challenge the general principles of XCI that were formerly defined in model organisms and to unravel human-specific features of XCI that could serve as new research paradigms in developmental epigenetics. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Salt tolerance studies in arabidopsis thaliana - genetic approaches for the identification of hypomorphic halotolerant mutants' (1994-1998).

assistant: **Innovation**

Research objectives and content Saline stress in agricultural crops is a major challenge to plant biotechnology. Although a genetic background to stress tolerance exists in halophytes, this is not available to breeders of crop plants. An application of biotechnological advances requires the knowledge of target genes responsible of salt tolerance.With the present proposal, we pretend to use the generated mutant lines by the host group plus other T-DNA insertional collections to identify new mutant alleles relevant to salt tolerance. The experience of the group in this topic will be very valuable in order to circumvent difficulties encountered in previous screenings. We expect to optimize the screening procedure, to use more specific selective agents for better discrimination between osmotic and ionic toxicity, and to be able to establish a feasible screening procedure at the seedling stage.By this means we hope to define new halotolerant mutants probably due to loss of function (hypomorfic) which might serve in the future to design biotechnological strategies with other plant species of agronomical interest to improve salt tolerance. Training content (objective, benefit and expected impact) The knowledge of the host group in genetics and the accumulated experience with previous screenings forsalt tolerance makes this proposal a very interesting training for the applicant who has been involved in this research topic in the last six years with different biological systems. At the same time the experience of the applicant in this field could benefit the research of the group. It could be envisaged an impact at the long term in the design of biotechnological strategies for improvement of salt resistance in crop plants. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Breakthrough Neoantigen-specific Tumor-Infiltrating Lymphocyte Therapies Through Novel Dendritic Cell Reprogramming'.

assistant: **Innovation**

Solid tumors present a significant challenge in oncology due to the limited efficacy of current therapies and resistance to immunotherapies like checkpoint inhibitors. While adoptive cell transfer (ACT) using Tumor-Infiltrating Lymphocytes (TIL) has shown promise in immunogenic tumors like melanoma, broader success has been hindered by inefficient TIL expansion, T-cell exhaustion, and low tumor reactivity (<0.5% tumor-reactive clones in TIL products). These limitations result in inconsistent outcomes and slow clinical adoption.The Repro-TIL project aims to address these challenges by establishing a first-in-class platform designed to selectively expand neoantigen-specific, tumor-reactive TILs. The project builds on the ERC POC project 'NeoIDC,' which introduced a novel method for reprogramming cancer cells into antigen-presenting conventional type 1 dendritic cells (cDC1s), leading to tumor-reactive T cell priming. Repro-TIL approach enhances the production of highly tumor-specific TILs, offering a more effective immunotherapy for solid tumor patients. Repro-TIL will focus on completing preclinical validation and CTA-enabling studies to reach TRL6. The project will optimize the platform for TIL expansion, identify biomarkers of TIL potency, develop a GMP-compliant manufacturing process, and establish regulatory and commercial pathways for future clinical trials and market entry.The project’s multidisciplinary consortium brings together expertise in translational immunotherapy, ACT manufacturing, regulatory strategy, and business development. This combination ensures successful project implementation and lays the groundwork for commercialization. By its conclusion, Repro-TIL will be positioned as a superior ACT solution, with the potential to significantly improve treatm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'New pv system technology'.

assistant: **Concept**

The objective of this project is to develop a highly innovative PV system concept (NST) which aims at removing the major weaknesses of state-of-the-art PV system technology such as - Varying lifetime expectancy of PV system components - Low degree of integration of electronic components - Sensitivity against shading - High cabling cost - Significant mismatch losses To overcome this situation high-level European PV system companies, amongst the the leading European PV module manufacturer, have joined their R&D efforts in a common industrial project aiming at the detailed development of this innovative PV system concept, the development, manufacture and test of NST component prototypes and the installation and monitoring of a NST pilot plant. In detail the industrial benefits are: l.A lifetime of balance of system components (in particular power transmissionand power conditioning equipment) matching the PV module lifetime (>25 years) 2.A Mean Time Between Failures MTBF of electronic equipment of > 100.000 hours 3.Highest integration of electronic circuits (ideally leading to theone-chipinverter") 4.Miniaturisation of electronic components due to magnetically induced energytransmission and conversion 5.Avoidance of mechano-electrical module connections (using magneticallyinduced coupling instead) At the end of project duration the industrial achievements of this extensive hardware development project will be as follows: - Tested and approved prototype of an innovative Magnetically Induced Power Bus (MIPB) Technology with fully integrated Magnet Power Receiver (MPR) for energy transmission from the PV module to the Power Bus. This technology will lead to higher system efficiency and reduced safety needs due to hermetical isolation of NST components. Patents will be applied
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Using Image Processing as a Metrological Solution (IPROMES)' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The metrology control plays an important role within the manufacturing industry in terms of size and dimension inspection. In the aeronautics sector, the metrology reaches its high criticise level, due to the high measurement precision required on large parts. The metrology operation is required not only during the final inspection, but also above all in the scope of the assembly process. Faced with this criticise and in order to take into account the size of the aircraft parts, from the early days of aircrafts manufacturing, the industrial actors uses complex frames which support both the parts to be controlled the manual instrument of measure. This solution is both time and cost consuming due to the characteristics of the frame, which guarantees the accuracy of the measure. This project aims at developing relevant photogrammetry and image processing techniques to perform the in-process" positioning (during the assembly phase) and "afterwards", to complete the final measurement control in the aeronautics sector. IPROMES addresses the FP6 aeronautics area "Strengthening and competitiveness" and particularly the research topics 1.3.1.1 b) manufacturing: flexible tooling, automated process and assembly, advanced manufacturing methods to reduce recurring and non-recurring cost while supporting volume flexibility in processing section and test techniques. IPROMES leads to a reduction of metrology cost by 3 and of measurement operation time by 2 in comparison with the laser radar solution. Compared to traditional frames with gauge solutions the time reduction can reach factor of 10 on control time."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The gut microbiota and its systemic effects on metabolism and atherosclerotic disease'.

assistant: **Concept**

Atherosclerosis is the main pathological mechanism causing myocardial infarction and ischemic stroke. Evidence has mounted about the association between the gut microbiota and cardiovascular disease, but whether the associations are causal is largely unknown. For optimal prevention and treatment of cardiovascular disease, there is an urgent need to determine whether there are any true effects that might be targeted by interventions. The overall goal of this project is to assess causality between gut microbiota and atherosclerotic disease and to provide easily accessible biomarkers for an atherosclerosis-enhancing gut microbiota. To this end, the research program has three main objectives: 1.) Identification of gut microbiota characteristics associated with atherosclerosis measured by coronary computed tomography angiography and high-resolution carotid ultrasound in a population-based sample of 10,000 individuals and through prospective follow-up for myocardial infarction and ischemic stroke. The microbiota will be characterized by next-generation sequencing techniques in faecal samples.2.) Identification of plasma biomarkers associated with an atherosclerosis- enhancing microbiota using comprehensive metabolomics profiling of 800 named metabolites in plasma from 800 individuals with replication in additional 800 individuals3.) Clarification of the causal effects of gut microbiota characteristics on atherosclerosis, myocardial infarction and stroke by development of novel genetic instruments and applying Mendelian Randomization analysisI have access to unique study materials and documented experience of successful projects using large scale -omics data and state-of-the-art epidemiological methodologies. My project is expected to lead to the identification of characterist