RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Investigating the microRNA-chromatin remodelling circuitry in cardiac development'.

assistant: **Concept**

Future treatments of cardiovascular conditions will benefit from our ability to harness progenitor cells or stem cells for therapeutic purpose. To achieve this promising goal the objective of this Marie-SkŁodowska-Curie Action is to dissect the molecular mechanisms that govern fundamental cellular differentiation processes in their normal physiological setting, the developing embryo. One such fundamental process is the control of cell lineage determination. This is important during both stem cell differentiation and embryo development, including heart development. In the heart, many of the diffusible signalling molecules, transcription factors and more recently non-coding RNAs and epigenetic factors that contribute to this process have been identified. This has facilitated rapid advances in our understanding of the molecular mechanisms underlying the control of cell fate choice, however many details remain to be elucidated. This Action will focus on enzyme complexes that remodel chromatin during the epigenetic changes that occur during heart development. These complexes, which consist of different BAF-subunits and a core enzyme called Brg1, determine whether or not chromatin is accessible to transcriptional regulators, and they form an important nexus governing lineage decisions. The Action will address an important gap in our understanding concerning the regulation of subunit composition of the complexes and how subunit composition affects their function. This project builds on recent pilot data and will use in vivo methods to investigate the regulation of chromatin remodelling factors by microRNAs during cardiac development in experimentally accessible chick embryos. Mechanistic gain- and loss-of-function experiments in embryos (WP1, WP2) will be complemented by genom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '(Nano)-Materials for cell Growth, Imaging and Communication' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

MaGIC intends to explore the use of nano/micro objects, in particular zeolite L, as materials for imaging, and, when the zeolites are used as substrates, for analyzing and manipulating cells. In particular in vivo and in vitro imaging, cell growth on nano/micro patterned zeolite monolayers, and understanding some of the processes of cell-to-cell communication are the ambitious goals of this proposal. We intend to achieve these goals through 5 objectives:1. Synthesis and characterization of zeolites and loading and trapping of dye molecules.2. Patterned zeolite monolayers and microcontact printing for asymmetric functionalization and cells transfer.3. Molecular imaging using nanoporous materials as multiresponsive probes.4. Cell growth, proliferation and stimulation of processes in spatially confined areas.5. Communication between cells and cell differentiation.The project is extremely challenging and if successful will open new horizons in the use of nanomaterials in combination with living systems and will develop new technologies for handling delicate substrates and assemblies. The numerous ideas and problems that MaGIC addresses are of fundamental importance and collectively represent an interesting approach to simply mimicking nature, connecting biological components to abiotic materials in order to understand the mechanisms of the biological systems or to take advantage of the unique properties of the ‘non-biological’ components in a natural setting (in vivo and in vitro). The stepwise approach, starting from the use of the nanomaterials for observing the surrounding environment (cell imaging), and proceeding to their assembly in functional architectures, culminates in the realization of special interfaces with the ambition to realize and study cell-to-cell communi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optimization of Gas Turbine Cooling Hole Ramp Configuration via Multi-Fidelity AI/ML Model' (OURLEM) targeting Horizon Europe.

assistant: **Abstract**

Gas turbines play several important roles in Europe, contributing to various sectors of the economy. According to the Polaris Market report, the global gas turbine market was valued at 22.25 billion USD in 2021 and is expected to grow at a CAGR of 6.3% till 2030. At this huge global market size, since fossil fuels are burned in gas turbines, they release greenhouse gases, including CO2. Based on the 2030 EU Climate Target Plan, sets Europe on a responsible path to becoming climate neutral by 2050, greenhouse gas emissions should be cut by at least 55% by 2030. Hydrogen gas turbines offer several advantages over fossil fuels, making them an attractive option for clean and sustainable energy generation (zero emissions), helping to face climate change, and reducing air pollution. However, hydrogen burns at a higher temperature compared to other fuels, which poses challenges for turbine blade cooling and requires an efficient cooling technique to maintain blade integrity. Film cooling, by injecting cold air at discrete locations over the exposed surfaces through holes and slots, is one of the available technologies. Additive structures, such as ramps, near the exit of the cooling hole geometry can be used to improve the film-cooling effectiveness, thus increasing the gas turbine efficiency. The geometrical configuration of the upstream ramp can significantly affect the cooling effectiveness on the surface and the mixing between coolant and mainstream. Therefore, the ramp configuration should be carefully designed. In this project, this goal will be achieved through a multidisciplinary optimization approach, based on the combination of experiments and high-fidelity Large Eddy Simulations, making use of Artificial Intelligence and Machine Learning approaches. The outcome of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Climate change experiment' (1994-1998).

assistant: **Concept**

To provide quantification of the ecosystem impacts of future climate change as well as providing essential rate and process data for the construction, calibration and validation of process-oriented models to predict the response of forests and freshwaters in Europe to future changes in atmospheric CO2 and climate.CLIMEX is an ongoing project in which the atmospheric CO2 is enriched to 560 ppmv and air temperature is raised by 5 C above ambient to an entire forested headwater catchment ecosystem. The experiment uses a 1200 m2 greenhouse located at Risdalsheia, southernmost Norway. CLIMEX began in December 1992 with the installation of measurement equipment. One year's background data (pre-treatment) was collected during the period April 1993 through March 1994. Treatment began in April 1994. CLIMEX II will continue the experiment through January 1997 giving 32 months treatment. CLIMEX is an integrated, whole-ecosystem research project studying the response of entire catchments to increased CO2 and temperature. It is 100 times larger than previous wholeecosystem CO2 and temperature experiments and achieves both CO2 and air temperature manipulation to mature forests in situ. This whole-catchment manipulation allows quantification of links between terrestrial and aquatic ecosystems and provides direct experimental evidence on the effect of climate change on (European) natural forests, terrestrial ecosystems and water resources. Theoretically, catchment ecosystems will show a cascade of responses to increased CO2 and temperature. The first expected step was observed in the first year of treatment: increased CO2 changed rates of photosynthesis and stomatal densities in several of the major plant species present at Risdalsheia. These responses are expected to cause further cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Lightweight Active Orthosis for kids who are unable to walk due to brain damage' (WalkableFUTURE), addressing dissemination and exploitation.

assistant: **Impact**

One in a thousand newborns has a severe condition of cerebral palsy (CP) so that he or she will not be able to walk at all, ever in life. This affects 5000 babies born each year in the EU, and cumulatively ~63,000 children. There is no known cure for the disease.Some active walking aids (e.g. exoskeletons) may help the child to walk, but they cannot be adapted for children, nor to the special lower limb deformities prevalent in this disease.We will disrupt the walking aid market with a new concept: robotized orthoses. We will build on professional walking aids and motorise them. Ours will be the only active orthosis for children with CP aimed for overground walking, and physiotherapy, as well. Our system does not take into consideration the “faulty” signals from the body, instead it is built on the ideal walking patterns pre-programmed, while a range of sensors anticipate the will of the user.The extensive survey through our distribution partners and potential clients revealed the need for our device that changes the quality of life in such a remarkable way.We will capitalise on the rapid growth enabled by the ease of market entry and fast distribution opportunity, to help hundreds of children every year.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'How musical rhythm moves humans: functional mechanisms of entrainment and perception-action coupling' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Entrainment to music is a culturally widespread activity with increasingly recognized pro-social andtherapeutic effects. Music powerfully compels us to move to the musical rhythm, showcasing theremarkable ability of humans to perceive and produce rhythmic inputs. However, the underlyingfunctional mechanisms remain unknown. One view, which dates back to Darwin, is that the relevantmechanisms are ancient and anchored in the evolutionary oldest subcortical parts of the brain.However, recent research argues that rhythm perception is a complex cognitive function involvingtemporally precise communication between cortical sensory and motor regions, even in the absenceof overt body movement or intention to move.This project aims to uncover these mechanisms by combining concepts and methods ofexperimental psychology and cognitive neuroscience. Specifically, the research will (i) unravel themechanisms at the interface of rhythmic inputs, motor skills and brain activity, (ii) establish theactive role of motor representations in rhythm perception, (iii) track the development of theseprocesses even prior to language in infants, and (iv) investigate the physiopathology and restorationof these processes in brain-damaged patients.To achieve these objectives, the project will use a comparable method across different experimentalsettings, the frequency-tagging approach, whose reliability and advantages have been recentlyestablished as an innovative method to capture neural entrainment to rhythm in humans. Resultswill provide important knowledge into how psychological, environmental and neural mechanismsaffect such entrainment. Clarifying these mechanisms provides an optimal framework to unravel therole of an intrinsic sensory-motor coupling underlying perception and how this coupling dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Critical paths to fuel cells (CPS2FCS)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

A great deal of excitement has been generated by the public introduction of the first fuel cell vehicles. Ultimately, the technology is likely to revolutionise transportation, as we know it. But for people who have spent decades trying to commercialise new clean fuels, the view that thousands of fuel cell vehicles will be on the road by 2004 is very optimistic. For fuel cells, the key question to be answered is: Which fuel will be the fuel of the future?" This question will be discussed in a Phase Zero workshop with the relevant stakeholders. The automotive sector likes liquids - gasoline and methanol. Natural gas (CH_4), with four parts hydrogen is another candidate. Some people believe a hydrogen infrastructure will be developed to deliver hydrogen to every fuel cell vehicle. Before fuel cells can begin to be commercialised, government and industry choices will have to be made about which fuel(s) will power fuel cell vehicles."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Smart Theranostic Agents for the Tumour Microenvironment' (FLUORODRUGS) targeting Horizon 2020.

assistant: **Abstract**

FLUORODRUGS is a highly interdisciplinary project encompassing the design, synthesis and biological validation of novel smart chemical agents for highly sensitive diagnosis and specific treatment of cancer. I will prepare novel drug-fluorophores conjugates by combining macrophage-specific fluorophores with cytotoxic drugs using smart cleavable linkers. The activation of these smart agents in the tumour microenvironment will allow to not only to visualise in real-time but also to selectively ablate tumour-associated macrophages, which are essential for cancer progression. Further derivatization of the agents with specific ligands (i.e. chemokine CCL2) will yield probes for specific subpopulations of macrophages (i.e. CCR2+ macrophages) that are critical in tumour metastasis. This strategy will minimise two of the major limitations of conventional cancer therapies: 1) drug resistance from cancer cells, and 2) toxic side effects derived from low cell specificity. Notably, the visualisation of immune cells in the tumour microenvironment will allow to monitor cancer progression in real-time and to run profiling studies to discover new biomarkers for cancer therapy. Initial in vitro studies to confirm the activity and selectivity of FLUORODRUGS will be performed in bone marrow-derived macrophages. Further, relevant mouse cancer models will be used to validate the theranostic agents in vivo. FLUORODRUGS will involve multidisciplinary training in biology, spectroscopy, pharmacology and imaging, and will render a unique generation of smart chemical tools to enhance diagnosis and treatment of cancer. This project will open a whole range of opportunities for my future career development in cancer biology and medicinal chemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DETECTION OF CEREBRAL ISCHEMIA BASED ON MACHINE LEARNING' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Stroke is the second cause of morbidity and the leading cause of long-term disability. More than 1.1 million people in Europe suffer a stroke each year, which will increase to 1.5 million in 2025 due to an ageing population and unhealthy lifestyle. Stroke diagnosis and care is notoriously complicated. Some improvements have been made in the clinic, such as through the introduction of CT Perfusion imaging technology (CTP) to allow for quantitation. There are, however, many concerns with current implementations resulting in poor accuracy.Nico.lab develops and markets unique Artificial Intelligence (AI) technology which analyzes brain imagery – such as a CT or MRI scan – and provides health professionals with treatment advice. CTP is a vastly different technology and is thus not yet supported by our AI analysis. Therefore, we want to research and develop novel algorithms to natively analyze CTP data and provide quick treatment advice.As we have no experience at all with CTP technology – not medically nor concerning software, and barely in a research capacity - we require someone who holds all these expertises. There are, however, several barriers currently withholding us, ranging from our lacking resources to demontstrably unavailable talent in The Netherlands. With this Innovation Associate grant we wish to hire the right talent. In this project the innovation associate will explore the technical and practical feasibility of developing data driven CTP algorithms. The innovation associate will obtain technical, practical and soft skills. Finally, the associate will deliver an innovation programme roadmap which can be implemented after finalization of this project.


**Keywords:** ICT, AI, Stroke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SOCIAL ENERGY MARKET PLAYERS TO TACKLE ENERGY POVERTY', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Regional and local public authorities have a strong role to play in fighting energy poverty. That is why the overall objective of POWER UP! is for cities to go beyond their planning role and sustain the creation of local energy market players with a social agenda. This will be realised by the following 3 specific objectives:- Implement pilot schemes for households in energy poverty, so that they benefit from renewable energy production and energy efficiency measures, without having to bear the financial risks;- Develop and reinforce local energy market players with a social agenda, based on a long-term perspective to acquire local knowledge and strengthen the local economy;- Disseminate the experience of the consortium members to facilitate the replication in European countries.Four pilot schemes will be developed in five locations across Europe: Eeklo (Belgium), in the Campania area (Italy), in Rožnov pod Radhoštěm (Czech Republic), and Valencia (Spain).These schemes will be co-created with energy-poor households and local stakeholders (cities, social organisations, energy utilities, citizen energy communities etc.), leading to at least 2,5 Million EUR investment in sustainable energy before the project ends and involving 58 333 energy poor consumers. Supported by a European city network, a leading UK university, a Belgium cooperative and finance experts, the consortium will build the capacity of more than 185 people in local organisations.  This will allow these players to either provide cheap energy to fuel poor households, or reinvesting benefits to carry out energy poverty mitigation measures.


**Keywords:** Energy poverty, Vulnerable households -Renewable Energy, Energy Communities, Energy efficiency, Local energy market players, Collaborative decision making,  B
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Early Modern Exchanges in Sanskrit Astral Sciences' (EMESAS).

assistant: **Concept**

During the period of Mughal rule (1500 to 1800 CE) in early modern India, traditional Sanskrit astronomers actively engaged with Islamic (Ptolemaic) astronomy for the very first time. The EMESAS project proposes to study the canonical works (siddhāntas) of three Sanskrit astronomers from the early 17th century: Nityānanda, Munīśvara, and Kamalākara. The aim of this study is to find and analyse 'knowledge elements' found in their texts that are of Islamic origin, e.g., computationalmethods, geometrical arguments, astronomical models, diagrammatic proofs, etc. In doing so, the EMESAS project will contextualize the process of transmission, reception, assimilation, and adaptation of Islamic ideas in medieval Sanskrit astronomy.The Centre for the Study of Indian Science (CSIS), hosted by the Department of Cross-Cultural and Religious Studies at University of Copenhagen (UCPH), specializes in research on different aspects of Indian astral sciences like saṃhitā (omens), horā (astrology), and gaṇita (mathematical astronomy). This makes CSIS ideally suited to host the EMESAS project.Under the supervision of Prof. Kenneth Zysk, the head of CSIS, the EMESAS project will examine Nityānanda's 'Sarvasiddhāntarāja' (1639 CE), Munīśvara’s 'Siddhāntasārvabhauma' (1646 CE), and Kamalākara’s'Siddhāntatattvaviveka' (1658 CE). The research expertise at CSIS will enable this project to ask challenging questions: What motivated Sanskrit authors to discuss Islamic astronomical theories? What kind of technical explanations, mathematical vocabularies, and cultural tropes did Sanskrit authors adopt in accepting (or rejecting) foreign ideas? How did the scientific milieu of early 17th century Mughal India influence the development of Sanskrit astronomy? To answer these questions, the EMESAS projec