RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'QUANTUM PHENOMENA IN BIOLOGY: THEORY AND EXPERIMENTS TOWARDS NOVEL SOLAR ENERGY QUANTUM TECHNOLOGIES', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Nowadays, the alarming trends in global energy demand and the finite nature of conventional oil and natural gas reserves are unavoidably leading to the urgency of finding and timely developing new renewable energy technologies, by facilitating also participation by qualified researchers. In this context, quantum biology is a new strategically important and rapidly developing research field, whose practical implementations will be crucial for novel and more powerful solar energy ‘quantum’ technologies and for the creation of a European knowledge-based bioeconomy.Here, we will investigate theoretically and experimentally the role of quantum effects in biology, especially in natural photosynthesis, by studying theoretical models of energy transport in quantum complex networks and testing them by means of designed experiments based on quantum optical simulators, cold atoms in optical lattices, and ultra-fast laser spectroscopy on natural and artificial light-harvesting biomolecules. It will allow us, first of all, to have a deeper understanding of how Nature has been exploiting, since billions of years, quantum coherence and environmental noise to get very efficient and robust energy transfer in photosynthesis, and, even more desirably, to design new clean energy structures and light-harvesting molecular geometries, leading to future ‘quantum’ solar cells more efficient than today’s photovoltaic ones.Finally, it will help the Researcher, Dr. F. Caruso, whose previous expertise makes him very well suited for this project, to be reintegrated for the first time in his own country, at LENS in Florence, after a period of mobility of three years in foreign countries (UK, Germany), to have his own research budget, to set up an independent team, to transfer his knowledge in quantum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '"Racial thinking and relevant sciences in East-Central Europe in the decades around 1900""""' (RACIALISM) under Seventh Framework.

assistant: **Objectives**

At the core of my proposed research lies the desire to understand turn-of-the-century European fascination with the idea of race and the employment of modern sciences in the construction of racial theories in national and imperial contexts of East-Central Europe. The project will explore the history of racial thinking and related biological, human and social sciences in the mostly uncharted region of East Central Europe, with special focus on the Hungarian Kingdom in the decades around 1900. Rooted in the ethnically and confessionally most mixed region of contemporary Europe, Hungarian sciences faced unique intellectual challenges in constructing racial theories and creating ethnic, national and imperial identities, thus contributing to the process of Hungarian nation-building while legitimating liberalism in general. To understand how race, ethnicity, the nation and the multi-ethnic kingdom were co-produced in the region, systematic research will explore a variety of scientific disciplines, including ethnography, sociology, physical anthropology, criminal and social statistics, biology, public health, eugenics, and crowd psychology. Based on the Applicant’s preliminary studies and research hypotheses, the disciplinary trajectories of Hungarian ‘sciences of race’ seem to diverge considerably from the models offered by the historiography in the British, French and German contexts. Rather exceptionally, in the Hungarian intellectual field, a marked and overall shift towards a biological, hierarchical, and racialist thinking did not seem to have taken place before the end of WWI. Due to the originality of the research and its interdisciplinary nature, the planned outcome, a monograph, will contribute not only to the historiography of European “racial sciences” and science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Film Colors. An Interdisciplinary Approach.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Film is in essence colored light projected onto a screen. Its aesthetics are thus highly determined by the material properties of film and the optical configuration of the cinematic apparatus. To this day, however, there is no systematic study of the relationship between the technology and aesthetics of film colors, despite the fact that, following the digital turn in film production and distribution, the understanding of this relationship is more essential than ever before.Over 200 film color processes were developed since the invention of film. They are presented on the Timeline of Historical Film Colors, which will be an integral part of the project.The groundbreaking nature of this project lies in a truly interdisciplinary research design with a novel methodology to explore the interaction of technological advances and limitations with film color aesthetics, identifying diachronic patterns of stylistic means. To this end it develops a tool through recent advancements in digital humanities for crowd-sourcing of color analyses of large groups of films. In-depth studies of technical papers and scientific measurements of film colors will investigate the technical basis of films’ aesthetic appearance. These insights will be applied to the digitization and restoration of historical films to explore and disseminate the results. While every serious art restoration connects scientific analyses with art-historical and aesthetic investigations, a similar approach is rarely applied to film. In summary, the present research proposal capitalizes on the principal investigator’s preceding studies to bridge the gap between technology and aesthetics. With the methods described here, the results will trace previously hidden roots of aesthetic developments of film colors. While the pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Third Generation Scaffolds for Tissue Engineering and Regenerative Medicine' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The project proposed is therefore a radically new approach to fabricate safe bioactive materials for tissue engineering and regenerative medicine. We propose to use cells as micro-factories to produce and assemble the molecular components at the nanometer level which is not possible by conventional mechanical engineering. This cellular engineering will be used to produce the supportive structure with desired shape, compliance and mechanical strength at meso- and macroscale levels. We achieve this by engine ering cells to express the desired components creating bioartificial scaffolds which mimick the natural extracellular matrix and will fulfil the requirements of mechanical support, compartmentalization, storage and sequestration of molecules. This also w ill have correct porosity allowing for diffusion of soluble molecules and access to cells, exposing ligands for adhesion and proliferation and being degradable by enzymatic mechanisms to allow body directed remodelling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synthesis and properties of trifluoromethylated Carbo- and Heterocycles' (TRIFLU) under Sixth Framework.

assistant: **Objectives**

Commercial interests in fluorine chemistry emerged in the eighties mainly due to the need to replace industrial chlorofluorocarbons but also because of the increasing use of organofluorine compounds in agrochemical, medicinal and in material science.Rational design exploiting the remarkable properties of F or CF3-containing group or substructures has been successful in the development of new and effective biochemical tools as well as medicinal and therapeutic agents.Nevertheless, progress is still hampered by the lack of general methodologies to access fluorinated compounds, more particularly homochiral targets or building blocks that feature a trifluoromethylated stereogenic centre.The development of new strategies to prepare organofluorine compounds remains indeed a challenge employing novel approaches to control the regio-, diastereo- and enantioselectivity of new fluorination or trifluoromethylation processes. The current proposal builds on our emerging interest in the use of organosilanes as starting materials for the preparation of various novel trifluoromethylated targets.We will study both a catalytic asymmetric Diels-Alder reaction using trifluoromethylated building blocks and explore a tandem cycloaddition/trifluoromethylation route with the aim to prepare structurally diverse trifluoromethylated carbo- and heterocycles.With these compounds in hand, we hope to improve our understanding of H/CF3 substitution effects by studying their physicochemical properties. Properties to be measured are solubility, lipophilicity/polarity, membrane permeation, acidity/basicity of surrounding groups and conformation.This type of study is important for drug discovery. The work will be carried out in the Chemistry Research Laboratory at the University of Ox ford by Arnaud Tessi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation' under Horizon 2020.

assistant: **Concept**

Extreme heat and wildland fires are identified as key climate risks in Europe. The two risks are interlinked, as the risk of wildland fires increases during periods of extreme heat and decreasing precipitation. Extreme heat increases the death and disease rates for cardiopulmonary disease (CPD). Wildland fires cause intense air pollution in the form of fine particulate matter (PM2.5) and ozone (O3). These are the two major air pollutants threatening human health in Europe, and their main health effects are related to CPD. Episodes of extreme temperatures and extreme levels of PM2.5 and O3 are likely to occur simultaneously and could occur more often, last longer, and become more intense in a warming world. EXHAUSTION will establish exposure projections for extreme heat and air pollution based on the most updated and advanced climate modeling efforts. EXHAUSTION has access to unique retrospective health registries on CPD mortality and morbidity in Northern, Central, and Southern European settings. In addition, EXHAUSTION draws upon a large time-series data base in a multi-country observational study. These data enable us to derive novel exposure-response relationships for heat, air pollution, and CPD. By combining the exposure projections and the exposure-response relationships, EXHAUSTION quantifies the future exacerbation of CPD in European settings and attributes the change in CPD mortality to a changing climate. EXHAUSTION will develop innovative adaptation strategies informed by epidemiological evidence, and address major inequity issues by identifying how age, sex, and indicators of socio-economic status (SES) predict probability for CPD caused by extreme heat and air pollution. EXHAUSTION will model socio-economic cost estimates for the response in CPD, and identi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Glaucoma prevention by computer aided diagnostics' in the context of a Fifth Framework call.

assistant: **Objectives**

Clinical and engineering experts co-operate to investigate the onset and progress of glaucomatous damages by utilisation of an existing optical data bank of about 16000 pairs of slides. Based on modern computer capacity, a software tool will be developed to reconstruct 3D images, calculate significant structures and volumes and superimpose images of different stages in a semi-automated way. This technique will be applied for the second examination of the existing slides. The medical findings will be reported as an assistance for other physicians and the software package will be edited for direct use in clinics or via a medical service MTU.· Server containing both the database and the software for processing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tumor recurrence and therapeutic resistance: exploring and exploiting the post-radiotherapy brain microenvironment for therapeutic opportunities in malignant brain tumors' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Gliomas are the most common brain tumors and the highest-grade glioma, glioblastoma (GBM), is arguably the most aggressive tumor type, with no long-term survivors. Patients with GBM are treated with radiotherapy, chemotherapy, surgery, and tumor treating fields. Despite initial response all tumors recur as incurable lesions; there is an urgent need for novel therapeutic approaches for this patient group. The majority of GBMs recur within the treatment field receiving high-dose radiotherapy during treatment of the primary tumor; the recurrent tumor thus forms in an irradiated microenvironment. Despite the fact that it is the recurrent tumor that ultimately kills the patient and that the majority of new therapeutic agents for GBM are tested clinically in the recurrent setting, the majority of experimental models and clinical materials for drug discovery are based on primary disease. Recent advances established a central role for the tumor microenvironment in determining the therapeutic response of GBM cells, and our lab demonstrated that standard of care radiotherapy of the primary tumor can shape the microenvironment to generate tumor-supportive conditions in the recurrent tumor; These findings suggest that there is untapped potential in targeting the irradiated microenvironment. This proposal aims to explore and exploit the recurrent brain tumor microenvironment by i) consolidating the contribution of the irradiated brain tumor microenvironment to GBM resistance by integrating spatial transcriptomics, single cell RNA sequencing, and multiplexed immunohistochemistry from state-of-the-art murine and human models of GBM treatment and recurrence, and ii) discovering and targeting novel therapeutic targets unique to the post-radiotherapy brain tumor microenvironment by high-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'CANCER PREVENTION VS CANCER TREATMENT: THE RARE TUMOUR RISK SYNDROMES BATTLE'.

assistant: **Concept**

Rare tumour risk syndromes (RTRS) are rare diseases, affecting 5 per 10.000 people or less and caused by heritable genetic variants. In RTRS, the lifetime risk to develop various cancers can be as high as 100%, and patients have a 50% chance of transmitting the disease to their offspring. When undiagnosed or not surveilled, many asymptomatic RTRS patients develop particularly aggressive cancers, leading to premature death, severely impacting theirs and their families’ health and wellbeing. Cancers in RTRS can be prevented and survival rates maximized if asymptomatic RTRS patients are intensively surveilled for RTRS-prone organs, cancer-prone organs are surgically removed prior to disease development, or very small cancerous or pre-cancerous lesions are removed or treated. RTRS are therefore a unique and tangible context for cancer prevention, early diagnosis and treatment with curative intent. However, risk-reduction strategies are not always prioritized in genetically diagnosed and asymptomatic RTRS patients, and most healthcare systems keep on opting for treatment of clinically expressed cancer. This occurs despite the knowledge that hospitalization has the highest weight on advanced cancer healthcare spending. It is therefore urgent to demonstrate the cost-benefit of the application of preventive measures in RTRS syndromes. The ambition of the PREVENTABLE project is to merge specialized clinical knowledge on RTRS pathways of care, real-life clinical data from RTRS patients and experiences from professionals and patients, with health economic models and social sciences approaches to estimate the cost-benefit of risk-reduction interventions in RTRS and delineate guidelines for its communication among and within clinical teams and RTRS patients. PREVENTABLE project resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'QUAlity aware VIsualisation for the Global Earth Observation system of systems' (GEOVIQUA) targeting Seventh Framework.

assistant: **Abstract**

The GEOSS Common Infrastructure provides clearinghouses and portals that allow discovery and visualisation of data in an integrated way. GEOVIQUA will extend the GEOSS infrastructure by adding well-defined data quality indicators and quality-enabled search and visualisation tools. These GEOVIQUA components will be implemented so they can be accessed based on existing geo-portal standards and in the mass market ""Google-like"" map tools and other 3D viewers, as well as on mobile devices. The design and development of GEOVIQUA components will be undertaken in collaboration with the relevant GEO committees, the Open Geospatial Consortium Architecture Implementation Pilots and other relevant standards committees.Data quality will be extracted from metadata, from provenance information, from the reference data, from validation with in-situ sensors and from expert user comments. Existing quality standards will be used or extended to formalise the quality indicators and provenance in line with the Quality Assurance for Earth Observation (QA4EO) framework and taken forward into the standardisation process.Graphical representation of metadata will allow users to easily screen data. Search functions will be augmented using quality indicators and search results will be able to be ranked by quality indicator. The work will contribute to a GEO S&T label increasing user trust in GEO product quality.Components will be developed to visualise data and associated quality information on GEO portals using different strategies. Work will link quality indicators and data in web map services and “Google like” tools, and make these available on mobile devices.Several pilot case studies ranging from local to global scales concerning many key Societal Benefit Areas will be used to motivate and v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Streamlining structural biology: Developing a high-throughput cloud-based cryo-electron tomography platform' (CryoET-CryoCloud).

assistant: **Innovation**

Cryo-electron microscopy (cryoEM) has revolutionized biomolecular research. It enables structure determination of proteins and their complexes at near-atomic resolution, informing on their mechanism of action and their role in disease. Importantly, it also assists the development of novel therapeutics. Cryo-electron tomography (cryoET) is an emerging cryoEM modality, which has demonstrated the potential of to determine protein structures at near-atomic resolution in their near-native environment. Importantly, cryoET provides snapshots of macromolecules during their function, allowing to capture different stages of biochemical reactions in the cell and inferring their temporal order. However, cryoET relies on extensive computational data analysis. Current analysis pipelines require extensive computational resources, various software packages, and a high degree of expertise to build and execute workflows for data analysis. Building on my previous research from the ERC Consolidator project BENDER project, I propose to create a cloud-based workflow for standardized and automated high-throughput cryoET data analysis (CryoET-CryoCloud).This solution will not only reduce analysis time from months to days, but it will also make the method accessible to a broad community by eliminating the need for investment into expensive computational infrastructure, and their maintenance through scarce qualified personnel. My proposed workflow will both enable and democratize high-content data analysis of cellular tomograms, thus dramatically increasing our knowledge of the molecular machinery inside the cell. To perform this work and reach market rapidly, I will perform CryoET-CryoCloud in very close collaboration with a team of people from the startup company CryoCloud, which emerged from