RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Analysis of the development of b cell clones and somatic hypermutation in autoimmune disease' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The origins of the self-reactive B cells in the autoimmune diseases systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are unknown, but clusters of B, T and dendritic cells, which may act as foci for presentation of self-antigens, are seen in rheumatoid synovial membranes and vasculitic lesions of SLE patients. The objectives of this project are to identify the germline Ig V-genes expressed by the B cells in these clusters, to analyse the pattern of somatic hypermutation in the expressed V-genes and from this, the family history of development of self-reactive B cell clones and whether they are driven by antigen selection.  Clusters of lymphocytes will be excised from stained sections of rheumatoid synovia and vasculitic lesions by micromanipulation. Recombined Ig V-genes will be amplified by PCR, cloned, sequenced and the number of B cell clones which have arisen from independent Ig V-gene recombinations determined. Family trees will be constructed showing the relationships between clone members by the pattern of V-region somatic hypermutation. In a normal immune response, competition for antigen results in selection of B cells with a high replacement to silent (R/S) ratio in hypervariable regions. The R/S ratios of the B cell clones from SLE and RA patients will be analysed to determine whether antigen selection is driving B cell proliferation in the cell clusters. Amino acid substitutions which occur repeatedly, indicative of affinity maturation, will be identified.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Meshes and Global Integration for Semiconductor Front-End Simulation' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The lack of appropriate tools for adaptive meshing of arbitrary, and partly time-dependent, non-planar geometries is the main bottleneck for the industrial use of three-dimensional process and device simulation. In MAGIC_FEAT this limitation will be removed. The required meshing tool will be developed in cooperation between a leading semiconductor company, a software house, semiconductor research institutions with special expertise in the fields of process simulation and meshing, and a leading meshing group. The activities include a topologically correct and accurate surface discretisation, the generation and adaptation of bulk meshes for fixed and time-dependent geometries, the integration of the newly developed meshing tools into an existing three-dimensional process simulator, and an evaluation at industrial benchmarks using advanced physical models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The mystery of differentiation: exploring the link between enhancer priming and cell cycle in ventral foregut stem cells' (EPiC-VFG).

assistant: **Concept**

Pluripotent stem cell differentiation to disease targeted cell types has historically produced poor or inconsistent outcomes. The Brickman lab recently suggested that pausing differentiation, allowing cells to grow, and catch up at the level of the enhancer network, leads to improved differentiation. In particular, the Brickman lab has demonstrated that expansion of endoderm at the ventral foregut stage (VFG) increases the efficiency and efficacy of pancreatic endocrine differentiation. The mechanism by which this occurs is unknown, but it involves the re-equilibration of enhancer networks and rearrangements in the cell cycle. I hypothesise that these two processes are tightly connected and to address cause and effects and understand the nature of this link, I will focus on how FOXA1, a factor required for expansion-specific pancreatic enhancer reorganization, acts to couple growth to genome rearrangement, how it interacts with the REST/CoREST/KBTBD4 complex to facilitate enhancer commissioning/decommissioning and finally whether proliferation-induced alterations to specific cell cycles phases drive this enhancer reconfiguration. The results of this project will significantly impact on regenerative medicine research as they will help formulating a differentiation protocol that produces in a more efficient way pancreatic endoderm and pancreatic endocrine cells. Although this fellowship exploits pancreatic differentiation as a model, its implications are broad, as a role of proliferation in preparing appropriate transcriptional responses for differentiating cells would represent a new paradigm for the link between growth and lineage specification.


**Keywords:** Enhancer priming, ventral foregut stem cells, transcription factors, pancreas differentiation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Melting And Geodynamic Models of Ascent' (MAGMA) targeting Horizon 2020.

assistant: **Abstract**

The production and migration of magma through the lithosphere results in spectacular geological processes such as volcanic eruptions, giant ore deposits, large magmatic intrusions, and is responsible for the formation of continents on Earth.Since magmatic systems develop on timescales of millions of years and are not directly accessible, we have to reconstruct them indirectly, such as by studying exhumed magmatic intrusions, or by using geophysical methods. Interpreting these data is complicated, as geophysical techniques only give a present-day snapshot, whereas the geological record yields an incomplete picture of the underlying processes. As a result, most existing ideas on how magmatic systems work remain conceptual and are not necessarily consistent with the mechanics of the lithosphere, which hampers our understanding of such processes.Here, we will develop and employ a new generation of 3D computer models to simulate the full magmatic system in arcs in a self-consistent manner, while taking both realistic rock rheologies and evolving melt chemistry into account. We will:1. Derive mechanically-consistent interpretations of active magmatic plumbing systems by combining geophysical and petrological data with geodynamic inverse models.2. Obtain insights into the physics of magma migration through arcs on geological timescales, by combining numerical simulations with geological constraints from exhumed arc roots, and by targeting several well-studied magmatic intrusions.3. Unravel how arcs are built on geological timescales, what the role and the rates of magmatic differentiation processes are in this, and how this may have formed continental crust on Earth.We can thus, for the first time, interpret the available data in a physically consistent manner. This will give
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Locating Intergenerational Ties, rematriating late-19th-century unpublished photographs of Sámi Women and Children' to be submitted under Horizon Europe.

assistant: **Abstract**

Employing a decolonial approach inspired by critical museology and Indigenous studies, LIT aims to initiate a visual restitution/rematriation process fostering attention to Sámi people’s experiences during colonial encounters, and to illuminate individual life-stories of women and children photographed by Italian anthropologists Mantegazza and Sommier between 1879 and 1886. It wishes to generate dialogical knowledge of unpublished visual/written materials, enabling Sámi communities of interest to gain access to these scholars’ photographs. In complex socio-historical Indigenous/settler contexts such as Sápmi (the Sámi homeland), Sámi people’s control over their own heritage has proved essential to processes of cultural and ethnopolitical self-determination. Part of the Sámi visual heritage consists of photographs taken - often through mild violence and coercion - by academics engaged in physical anthropological practices involving Sámi individuals of all ages and genders. The resulting academic and divulgative publications circulated in Europe for decades, shaping and reinforcing stereotypes of Sámi peoples and cultures. Photos taken in colonial encounters by late-19th/early-20th century scholars to visualize Sámi people’s supposed biological-cultural inferiority (until a few decades ago inaccessible to the Sámi) have become important means of decolonization and empowerment through art and activism. The visual restitution of such photographs is of the utmost importance not only from a cultural heritage perspective but is also considered by Sámi institutions and individuals as an urgent necessity. LIT proposes an innovative approach based on the co-construction of knowledge and with a gender dimension. I shall reconstruct life stories of women and children photographed b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanoscale organisation of axo-axonic synapses along the axon initial segment of cortical pyramidal neurons in health and disease.' (Nano-axo-syn), addressing dissemination and exploitation.

assistant: **Impact**

Neurons in the brain have extensive dendritic arbours that receive thousands of synaptic inputs all along it. The transformation of all these inputs to an output in a single neuron occurs through the integration of synaptic events and the generation of an action potential (AP) at the axon initial segment (AIS). The AIS, therefore, is the site that controls neuronal output by gating the generation of APs. It has been recently shown that this neuronal compartment can be reorganized following a change in neuronal activity and that this structural plasticity is associated with a change in neuronal excitability. In addition, the AIS of pyramidal neurons is innervated by a specific type of inhibitory interneuron, a Chandelier cell, that forms axo-axonic connections specifically with it. Therefore, the AIS can be seen as a short stretch of axon that brings together molecules critical for AP initiation (e.g. - voltage-gated channels) and synaptic proteins essential for the local modulation of excitability. The interplay between these two compartments at the nanoscale level is not known. At classical excitatory and inhibitory synapses, the nanoscale molecular organisation of synaptic proteins has been shown to be a key factor in modulating the efficiency of synaptic transmission between neurons. However, the precise molecular organisation of axo-axonic synapses is still poorly understood, as is its role in regulating neuronal output. We propose to decipher this organisation in mouse brain slices using the state-of-the-art super-resolution microscopy combined with electrophysiology. Once the nanoscopic arrangement elucidated, we will study how it is modified during activity-dependent forms of plasticity and how this, in turn, leads to changes in neuronal excitability. Finally, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Carbon Nanotube Quantum Circuits' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The aim of this proposal is to use spin qubits defined in carbon nanotube quantum dots to demonstrate measurement-based entanglement in an all-electrical and scalable solid-state architecture. The project makes use of spin-orbit interaction to drive spin rotations in the carbon nanotube host system and hyperfine interaction to store quantum information in the nuclear spin states. The proposal builds on techniques developed by the principal investigator for fast and non-invasive read-out of the electron spin qubits using radio-frequency reflectometry and spin-to-charge conversion.Any quantum computer requires entanglement. One route to achieve entanglement between electron spin qubits in quantum dots is to use the direct interaction of neighbouring qubits due to their electron wavefunction overlap. This approach, however, becomes rapidly impractical for any large scale quantum processor, as distant qubits can only be entangled through the use of qubits in between. Here I propose an alternative strategy which makes use of an intriguing quantum mechanical effect by which two spatially separated spin qubits coupled to a single electrical resonator become entangled if a measurement cannot tell them apart.The quantum information encoded in the entangled electron spin qubits will be transferred to carbon-13 nuclear spins which are used as a quantum memory with coherence times that exceed seconds. Entanglement with further qubits then proceeds again via projective measurements of the electron spin qubits without risk of losing the existing entanglement. When entanglement of the electron spin qubits is heralded – which might take several attempts – the quantum information is transferred again to the nuclear spin states. This allows for the coupling of large numbers of physically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Broadband to rural America over satellite integrated links' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

BRASIL is a Specific Support Action where the main objectives are focused on important aspects of interactive applications via satellite in Latin America, with specific focus on Brazil, and on DVB-RCS. BRASIL thus targets SO 2.6.5/1, but also covers objectives of SO 2.6.5/2. A main objective of BRASIL is to identify constituencies and potentialities for deeper strategic cooperation and establish privileged partnerships opening opportunities for the joint development of DVB technologies and associated interactive applications and services. Brasil has a large focus on bridging the digital divide through government initiatives, and satellites will play a key role in meeting this objective. Technical focus as such should demonstrate a sufficient level of maturity with respect to previous actions related to international cooperation.The target region for BRASIL is Latin America in general, but specifically supporting European interactive satellite broadcast communications technologies such as DVB-RCS in Brazil. Latin America has been strongly influenced and dominated by US technologies. There is a significant potential for Europe to contribute to solving Latin American communication needs with European technology as well as a valuable benefit for Latin America.Reciprocally there is great benefit for European DVB-RCS industry from Latin-American initiatives that can stimulate the developing European market and help the industry struggling with the slow service roll-out. SME cooperation between Europe and Latin-America in the field of satellite communication is an important element of deeper strategic cooperation, recognizing that the majority of Brazilian companies (98%) are SMEs. Europe's DVB-RCS equipment market is currently driven by almost solely by SMEs. BRASIL will be f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nanostructured materials' (1998-2002).

assistant: **Concept**

Heard already something about nano"? Yes, this is one of the major slogans in research in the 21^st century and yes, it is a very interesting research field not only for physicists and materials scientists but also for chemists. This Marie Currie Training Site likes to offer you the possibility to prepare a variety of nanomaterials such a nanopowders and particles, nanostructured and porous inorganic materials and inorganic-organic nanocomposites in an interdisciplinary approach. Methods like supramolecular templating, sol-gel processes, micro emulsions, and chemical vapor deposition will be used. You will have the chance to focus on one nano-topic and work on that material from the very beginning in the preparation to the very end in the characterization. And who knows, probably the nanomaterial you have developed has properties that are interesting for industrial applications. In addition to the preparative and analytical skills we try to educate you to work together with chemists, physicists and materials scientist on an interdisciplinary topic. In a world where communication is one of the most important skills we like you to learn how you can communicate and present your results in the best way. If you are interested simply contact us and probably we can take you with us into the adventures of the nanoworld. As an applicant for this Marie Curie Training Site you should have a graduate degree in chemistry or materials science and you should work on your PhD thesis. We would like to host up to two fellows a year for nine months each fellow. Vienna University of Technology operates an equal opportunities policy and applications are welcome from all who satisfy the Marie Curie criteria."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Randomness and structure in combinatorics' to be submitted under Horizon Europe.

assistant: **Abstract**

Randomness plays an inseparable role in combinatorics. Indeed, non-constructive probabilistic arguments are a powerful way to prove the existence of various kinds of combinatorial objects, and the study of random discrete structures has illuminated nearly all fields of combinatorics. I propose a program to achieve a deeper understanding of this role of randomness in combinatorics, emphasising the relationship between “structured” (hence explicit) objects, and random or “random-like” objects.A) There are many situations in combinatorics where probabilistic arguments demonstrate that “almost all” objects satisfy a certain property, but it is difficult to explicitly specify an object with the property. The most notorious examples are in Ramsey theory, which studies how “disordered” it is possible for an object to be. I plan to investigate the structure of Ramsey graphs, with the goals of unifying the area and making decisive progress on important conjectures.B) Conversely, certain areas of combinatorics have been slower to benefit from the probabilistic method; particularly areas in which algebraic constructions play a major role. Design theory is the study of combinatorial “arrangements” with very strong regularity properties, most naturally obtained by exploiting symmetry/regularity properties of algebraic structures. I plan to investigate probabilistic aspects of design theory, and in particular to build a theory of random designs.C) Actually, structure and randomness often come together, due to the “structure vs pseudorandomness dichotomy” elucidated by Tao. Indeed, there are many important problems in combinatorics for which it is known how to solve both random instances and “structured” instances; in such cases we hope to decompose general instances into structured a