RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'International workshop on terahertz radiation in biological research, investigations on diagnostics and study on potential genotoxic effects - capri, italy 29 september - 2 october 2002' in the context of a Fifth Framework call.

assistant: **Objectives**

An International workshop on the study of the interaction of Terahertz (The) radiation with biological systems will be organized. The radiation covers the frequency range between 100 GHz and 20 The (i.e. a wavelength between 3 mm and 15 um), which spans the spectral interval between the microwave and the infrared regions of the electromagnetic spectrum. Topics of the Workshop include:- spectroscopic measurements on biological systems of increasing complexity- mechanisms of interaction and effects induced by the electromagnetic field - safety issues - technological developments of terahertz sources and systems for biomedical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nationwide prospective study on community-acquired bacterial meningitis: from genetics to therapy' under Seventh Framework.

assistant: **Concept**

Meningitis is an inflammation of the membranes covering the brain and spinal cord (the meninges). Each year 35,000 European patients suffer from bacterial meningitis, resulting in 7000 deaths and leaving 7000 disabled. Streptococcus pneumoniae and Neisseria meningitidis are the most common causative bacteria of bacterial meningitis. These bacteria are common colonizers, but in some individuals, they are able to spread to the bloodstream, slip through the blood-brain barrier and cause meningitis, with devastating consequences. Genetics of host and pathogen are considered crucial in this host-pathogen interaction. Our objectives are to identify and characterize host genetic traits and bacterial virulence factors controlling occurrence and outcome of bacterial meningitis. In a nationwide prospective cohort study, using pathway and total exome sequencing, we will search for genetic variants in 2000 patients with community-acquired bacterial meningitis and 2000 controls. On the pathogen side, using whole genome sequencing, we will systematically search for new bacterial virulence factors in the 2000 causative bacteria. Subsequently, by analyzing clinical data, serum and cerebrospinal fluid, we will examine the potential impact and functionality of these host and pathogen factors. Next, we will validate and explore our findings in an animal model of meningitis and investigate whether treatment against these specific components can improve outcome. Finally, we will initiate an open-access European database on the genetics in bacterial meningitis. In addressing our objectives, I will combine my expertise in bacterial meningitis with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and a mouse model. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The neural basis of prosocial development in adolescence' in the context of a Horizon 2020 call.

assistant: **Objectives**

Adolescence is an important transition period in life, where individuals gain independence from their caregivers and develop into adults who pursue their own goals. Our understanding of this transition period has benefited from two decades of research on brain development, in which it was discovered that adolescence represents a period of risk for heightened emotional reactivity, and that the developing brain in adolescence is much more plastic than previously thought. The existing models, however, have often ignored how these aspects of normative development have adaptive functions. In this proposal, I will use the original approach of testing for the first time the hypothesis that the very same emotional reactivity that was previously argued to create risks for potential negative developmental trajectories (including risk for substance abuse, delinquency) may under other circumstances create opportunities for prosocial developmental trajectories (voluntary behavior to benefit others) – such as by fostering cooperation, sharing and helping.For this purpose, I will measure functional and structural brain development longitudinally across the age range 10-21 years. I will test linear versus non-linear developmental patterns of brain activity for three key aspects of prosocial development (cooperation, sharing, and helping). This focus on positive development will provide a turning point in our understanding of adolescent brain development. The program will make the additional step of testing an intervention for prosocial development. An experimental longitudinal intervention study is crucial for the question whether adolescence is a window of opportunity for prosocial development. A mechanistic understanding of the different phases of adolescent development will prove us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Regeneration of pulse shape, amplitude and timing' (REPEAT), addressing dissemination and exploitation.

assistant: **Impact**

Main ObjectiveThe aim of the project is to study signal 3R regeneration in the context of optical fibre communications. The three Rs refer respectively to the three main requirements of regeneration: Reamplifying, Reshaping and Retiming.In copper-based communication systems, conventional electronic 3R regeneration is a well-known technique to overcome span or bit rate limits. An equivalent regeneration is needed for high bit rate signals carried by optical fibre. In an all-optical network context, the need is even more acute as the optical signal may not only travel over very long distances but also go through many switching nodes. In all these cases, noise and distortion accumulate and full regeneration is necessary to restore clean optical data signals. Finally, optical 3R regenerators as interface devices would ease network interoperability.Today regeneration may be performed by optoelectronic conversion followed by electronic 3R regeneration. This method is not well adapted to high bit-rate, time and wavelength multiplexed optical signals. Within this project, several new optoelectronic and all-optical 3R regenerators will be considered with two main objectives :  -To assess performances and to compare with present regenerators  -To determine potential strategic advantages of 3R regenerators for optical signals Technical ApproachThree basic 3R regenerators for optical signals can be considered.Regenerator TypesAll-optical 3R regenerator The optical data signal is typically split in two. One part is input to an all-optical clock recovery device (mode-locked or self-pulsating laser) which emits a clean train of optical pulses at the bit rate frequency of the data. The all-optical decision circuit uses typically the second part of the data signal to modulate the clean
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Initial conditions of exoplanet formation in protoplanetary disks' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

There is now a substantial population of exoplanets with well-determined masses, radii, and orbital parameters in a range of host stellar systems. JWST will bring an increase in exoplanets with atmospheric spectroscopy measurements, moving the field from pure discovery to population synthesis and characterization. Many of the best-studied planetary systems are massive and located within 1AU of their central stars; it is not clear whether all of these planets migrated from farther out in their natal disks to this location or if they could have formed in situ. Both scenarios should produce distinct compositions resulting from multiple strong, time-dependent chemical gradients in their disks due to thermal sublimation and grain processing effects. These effects likely set the bulk chemical composition of the planet’s core and atmosphere, which are accreted from different material in the disk. By determining the physical conditions within 1AU, I will confirm whether they are sufficient to support in situ planet formation.  I will also map the distribution of key planetary building blocks in both the solid phase (dust grains) and gas phase. This will be accomplished by interpreting disks’ flux as a function of wavelength with radiative transfer models including detailed sublimation and condensation physics, and comparing observed spectral features in both the solid and gaseous phases in molecular and atomic form to those predicted by models. This project will provide training through research in numerical methods and exoplanet characterization techniques, which are important in the long term for my career goals to lead a research group in planetary formation. Through development courses, I will improve my marketability for senior research positions and in turn transfer my in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Agricultural Research for Development Dimension of the European Research Area' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

ERA-ARD II has two strategic objectives: Improving the European contribution to International Agricultural Research (IAR) by promoting joint activities and trans-national programs in the field of Agricultural Research for Development (ARD). Increasing the impact of European contributions in achieving the Millennium Development Goals (MDG’s) and to sustainable growth in the poorest countries in the world. Achievements of ERA ARD I are: ERA-ARD provided a shared vision and a strategic agenda on ARD in Europe ERA-ARD provided an analysis of collaboration models to the implementation of joint and transnational activities ERA-ARD realised increased involvement of Southern partners through the establishment of a Southern Advisory Group ERA-ARD implemented a transnational call on “Bioenergy”. The areas for improvement are: Enlargement of the consortium by integrating new Countries (Portugal, Turkey, Finland, etc.). Expand joint and transnational activities initiated during ERA-ARD I Realise joint activities in the Thematic fields: Capacity development, Agri-Food Chain Security and Food & Energy , also related to climate change Involve the end users of the European ARD programmes in the design and implementation of joint and transnational activities Expend the Southern Advisory Group to include stakeholders from all continents The impacts of this ERA-net lies in supporting and enhancing the European Research Area for Development. A greater contribution and visibility of Europe towards achieving the Millennium Development Goals through an increase in effectiveness and efficiency of its research for development programs will be established along with the development of a more coherent European ARD and a facilitated access of developing countries to European ARD expertise. The joi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Studies on the efficacy of neuronal receptor antagonists and anti-inflammatory agents on the prevention of neuronal injury in hiv encephalitis' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content Many adults and especially children with AIDS suffer from AIDS Dementia due to the HIV replication in brain tissue. Interestingly, neurons, the primary cell responsible for memory and motor functions, are not infected by the virus. In contrast, immune cells called macrophages and microglia are the principal target cells for virus. It is known that brain macrophages, when immune activated produce factors that damage neurons. In order to understand the way neurotoxins are manufactured during virus infection, we will develop an experimental system that consists of cocultures between HIV-1-infected macrophages and neurons that allow quantitative studies on the outgrowth of neurites. Since the characteristics of outgrowth of neurites affect neuronal development and survival, this model can be used to evaluate the reversible effect of therapeutic treatment of neuronal injury mediated by HIV-infected macrophages. Therefore, we wish to evaluate the efficacy of two groups of compounds that either protects neurons from injury and death or prevents the detrimental effects of neurotoxin production by HIV-infected brain macrophages in order to develop therapeutic strategies for this HIV-associated neurological disease. Training content (objective, benefit and expected impact) The main objective of this proposal is the development of unique in-vitro models. That will require great knowledge in cell culture techniques, monocyte isolation, PCR and ELISA The drug trials are a challenge because the drug quantities are not yet defined and have to be studied and tested. The goal is to find drugs that can prevent neuronal injury and that are suitable for in-vivo testing and maybe, in the future, some new drug can be produced for Links with industry / industri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mantle cell lymphomas (MCL) - Biologic and clinical charaterisation and prospective evaluation of myeloablative radio-chemotherapy with blood stem cell transplanatation' to be submitted under Fourth Framework.

assistant: **Abstract**

Mantle lymphomas (MCL) represent a recently recognised sub-type of malignant lymphomas which are charaterised by a specific histology and immunophenotype and an unfavourable clinical course. Hence, response to chemotherapy is poor and patients with this disease usually face a median survival of less than three years. The recent discovery that MCL are associated with a specific chromosomal abnormality, the translocation t (11;14) that leads to the deregulation of cyclin D 1 and over-expression of bcl 1 and a consecutive impairment of cell cycle control has opened new perspectives to better understand the biology of this lymphoma and also potentially its clinical course. The current multinational study aims at gaining new insights into the biology of MCL and its appropriate clinical management and tries to explore a novel therapeutic strategy comprising myeloablative radio-chemotherapy with subsequent peripheral blood stem cell transplantation. These objectives are addressed in three major steps :  - The assessment of clinical and histopathologic features of presentation as obtained from a retrospective analysis of patients that have been treated with conventional therapies at the participating institutions; - The biologic characterisation of MCL by means of modern immunophenotypic and molecular techniques; - The prospective evaluation of myeloablative radio-chemotherapy with subsequent blood stem cell transplantation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards safer road traffic in Eastern Mediterranean region' (SAFEAST).

assistant: **Innovation**

Every year over 41,000 people die and 1.6 million get injured in European road traffic. There are, however, considerable regional differences in the number of traffic deaths. In 2000, 159 Finns and 118 Britons per million motor vehicles were killed in traffic accidents whereas the corresponding figure for Turkey was 536 and for Greece 427.Despite this vast difference between the Southern and Northern Europe in traffic safety, the reasons behind different accident risk figures have remained mainly unexamined. The objective for the European transport policy is to halve the number of road fatalities by the year 2010. This objective can be achieved only if traffic safety interventions are targeted to regions with high road fatality rates, like Eastern Mediterranean region.This project is aimed at improving the knowledge and research skills of Eastern Mediterranean traffic researchers by training experienced researchers in Greece and Turkey and sending selected researchers to the leading road safety research institutes in EU. The actions will target following new or under-developed priority areas in traffic safety research in Eastern Mediterranean region: human factors, societal factors in traffic safety, driving abilities of elderly professional drivers, and social psychological models of traffic behaviour.New research and training in these theory-based research areas will produce practical applications for driver education and licensing, enforcement, driver selection and engineering solutions. This project is a multi-disciplinary project in which traffic safety experts from different fields and countries will be working together.Core group of researchers from Turkey will be sent to a specialized training period to partner institutes. After returning to host institute, thes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Sustainable Plan for Integrated Development through the European Rail network – Projecting Logistics & mobility for Urban Spatial design evolution'.

assistant: **Objectives**

SPIDER PLUS objective is to provide a new 2050 mobility VISION through a Strategic Design & Plan, and a Road Map delivering Sustainable Solutions by then. In such Plan the electrified Rail has a central role both for passengers and freight. The productivity of the available resources supported by ICT and other technologies, is maximized by the combination of infrastructural nodes with spatial and urban planning integrating the missing links for sustainable mobility and city logistics. The combination of the Time with Space management generates seamless transport chains reducing aggravations and costs. E/Service, E/Freight, ICT technologies, satellite communications, Galileo are tools for achieving these objectives. Syncro-Mobility is the 2050 SPIDER PLUS MOBILITY motto.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Coordination of Transmission and Distribution data eXchanges for renewables integration in the European marketplace through Advanced, Scalable and Secure ICT Systems and Tools' to be submitted under Horizon 2020.

assistant: **Abstract**

This project aims to design and develop novel Information and Communication Technology (ICT) tools and techniques that facilitate scalable and secure information systems and data exchange between Transmission System Operator (TSO) and Distribution System Operator (DSO). The three novel aspects of ICT tools and techniques to be developed in the project are: scalability – ability to deal with new users and increasingly larger volumes of information and data; security – protection against external threats and attacks; and interoperability –information exchange and communications based on existing and emerging international smart grid ICT standards.The project focuses on TSO-DSO interoperability. While TSO-TSO interoperability is currently well established by ENTSO-E through implementation of the Common Grid Model Exchange System, TSO-DSO interoperability will also benefit future TSO-TSO interoperability. In this context the project will also consider DSO to other Market-participants (DSOs, Aggregators, Distributed Energy Resource Operators, Micro-grid Operators) and information or data access portals that enable business processes involving relevant actors in the electrical power sector.Beyond state-of-the-art progress that will be achieved:Fully defined interface specifications for TSO-DSO information exchange interfaces based on Use Case analysis and IEC 61970/61968/62325 standards to support highly automated information exchange and network analysis.Fully defined interface specifications for information exchange between DSOs and market participants based on Use Case analysis and IEC 61850 and IEC 62325 standards to support highly automated information exchanges.Role-based access control that securely accommodates new data requirements and unbundling processes.A specifie