RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The inflammatory gene expression program in macrophages: An integrative approach for the systematic characterization of transcriptional co-regulators' under Horizon 2020.

assistant: **Concept**

Tissue responses to microbial and endogenous danger signals involve the activation of both resident and monocyte-derived macrophages, as well as the coordinated inducible expression of hundreds of inflammatory genes. Gene transcription is controlled by the information contained in thousands of genomic regulatory elements  (enhancers and promoters), which is first read by transcription factors (TFs) and then integrated and relayed to the transcriptional machinery via an array of co-regulators with disparate biochemical activities and functions. The recent work of several groups, including our own, has extensively characterized how in macrophages the genomic regulatory sequences controlling inflammatory gene expression are coordinately bound and activated by myeloid lineage-determining TFs and broadly expressed stimulus-activated TFs. However, we still have a very incomplete understanding of the necessary next step in the process, namely how distinct combinations of DNA-bound TFs regulate recruitment and function of the co-regulators and machineries that control gene transcription. Here, I propose to systematically identify the complement of co-regulators that control the induction of inflammatory genes in macrophages, which will be then mechanistically and functionally characterized both in vitro and in vivo. By integrating cutting edge genomic and computational approaches with focused genetic screens and biochemical analyses, and eventually validating relevant results in mouse models, this project aims at obtaining an unprecedented level of understanding of the information flow linking genomic regulatory elements to inflammatory gene transcription.


**Keywords:** Macrophages; transcription; transcription factors; chromatin; epigenetics and gene regulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Optimisation and flight qualification for the Airborne Polar Experiment (A.P.E.)'.

assistant: **Objectives**

The purpose of the present project is to prepare SAFIRE-A instrument for use on the Geophysika aircraft in view of the planned Airborne Polar Experiment (APE). This will involve flight qualification of the integrated instrument in simulated aircraft environments not only to assure its operation but also to verify that it meets specified safety requirements. The instrument will allow the characterisation of the ozone chemistry with simultaneous measurement of ozone and several other molecules including, for the first time, the critically important HOX species. Furthermore, the absence in the APE programme of middle-infrared and millimetre-wave instruments results in there being no capability for measurements of some critical species in the ClOX and NOX cycles. In order to fill this gap it is proposed to take advantage of the versatility of the SAFIRE-A instrument by constructing a second Cold Optics Detector Module which includes a long-wavelength channel (LW-CODM) to provide measurements of ClO, NO2 and HNO3 whilst retaining coverage in a second channel of the key HOX species.SAFIRE-A is based on experience gained with a similar instrument used on balloon borne platforms and exploits  design improvements identified in the Phase A study for a space borne version of the instrument. Il uses a new  interferometric movement, that is more compact and provides optical compensation of mechanical errors, as well  as narrow band filters and a cold pupil which exploit photon noise limited detectors. The instrument performs  limb emission observations in the 10 to 200 cm-1 spectral region with a resolution of 0.004 cm-1. In the APE  campaign one detector will be optimised for detection of ClO, N2O, HNO3 and O3, and one detector will be  optimised for detection of HO2, HOCl, HCl, HD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Contact-induced blade-casing interactions in aero-engine turbines - An integrated simulation framework for local and global nonlinearities' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Gas turbines play a vital role in terms of energy and mobility in 21st century. Accurate simulation tools are mandatory to increase competitiveness by increasing safety and reducing development costs.The growing tendency of designers to increase the efficiency of turbines has led to reduced operating clearances between rotating and static components and consequently frequent structural contact during operation. On top of that, the design tendency to reductions in fuel burn, noise and emissions makes the structural components lighter, slenderer and under greater excitation which increases their geometrically nonlinear behavior.Reliable analysis of the dynamic response of a turbine during blade-casing contact-induced interactions is of great importance due to its impact on fatigue life or potential catastrophic failure.The project aims at developing a validated numerical tool to predict the vibration due to blade-casing interactions. High computational efficiency will be granted by a nonlinear model order reduction technique able to handle both contact (local) and geometric (global) nonlinearities.The numerical predictive tool will be experimentally validated, taking advantage of the experimental equipment available at the host institution.The BC-Ints project aims at developing and validating mathematical and numerical models where both local and global nonlinearities are taken into account for an accurate prediction of the dynamic behaviour of rotors in case of blade-casing interactions.


**Keywords:** Bladed disk, blade-casing interaction, contact dynamics, geometric nonlinearity, blade tip rubbing,  modal interaction, Experiment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Increased uptake of CRAFT awards from SMES in the European CERAMIcs industry' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

CERAMICRAFT is an initiative within the Economic & Technological Intelligence programme to promote the use of CRAFT and other SME Specific Measure opportunities by the ceramics industry in Europe. The project will address the problem that the ceramics industry in Europe is fragmented, with many small companies competing with each other in local markets. In general they do not collaborate to compete more efficiently with imports from non-European suppliers or to export more aggressively. A consortium of NCPs and specialist ceramic RTD performers [CERLABS] from 11 countries will collaborate to determine and co-ordinate the business & technological needs for future prosperity and to encourage & facilitate the preparation of proposals for Commission funded RTD projects. The ultimate objective is to submit 40 CRAFT Exploratory and other proposals focussed on the key business issues. In addition, professional assistance will be given to SMEs who are currently engaged in EC funded projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Research and Development in Coal-fired Supercritical Power Plant with Post-combustion Carbon Capture using Process Systems Engineering techniques', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The proposed joint exchange programme on Coal-fired Supercritical Power Plant with Post-combustion Carbon Capture using chemical absorption is to develop and maintain long term collaborations between European and Chinese universities by carrying out joint research in process model development, process analysis, operation, controller design and optimisation for reliable and optimal design, operation and control of coal-fired supercritical power plant integrated with post-combustion carbon capture through individual mobility of researchers between Europe and China.   There are 7 partners involved (four from Europe and another three from China). These partners are world leading in their respective research areas.   The project is planned to start from 1 Jan. 2014 and continue for 48 months. There will be 21 experienced researchers and 19 early stage researchers participating in the joint research programme with exchange visits of 168 man months. The resources of €352,800 will be requested from this Europe Union Marie Curie Action to support these exchange visits.  The European partners are experts at heat transfer, carbon capture plant modelling and simulation, CFD studies, process control and monitoring, whilst the Chinese partners are experts at coal-fired supercritical power plants, synthesis of solvents for carbon capture based on molecular design, molecular simulation, process control and optimisation. Mutual transfer of knowledge and skills will take place through these exchange visits.   Successful completion of the proposed joint research programme will help build long term collaborations in clean coal technologies between Europe and China. It will also publish 30 Journal papers and 50 Conference papers. Three special sessions in major international conferences in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The provision of access to the isis pulsed muon facility' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Description:ISIS is the word's most intense source of pulsed muons for condensed matter investigations, and is the only pulsed muon source within the EC. Muon Spin Rotation or Relaxation experiments are carried out on two permanently installed spectrometers, MuSR and EMU, and there is in addition a development beamline, DEVA, used for advancing new techniques. Muons provide a powerful probe of the structure and dynamics of materials, with applications of the technique including investigation of magnetic, superconducting, metallic, semiconducting, ion-conducting, amorphous and molecular materials.The ISIS Pulsed Muon Facility was completed in 1994 following the award of a contract under EC Framework Programme 2; this contract also established a Muon Users Programme for EC researchers. Access for European scientists has continued under Framework Programmes 4 and 5, the latter providing for a total of 95 days of access for European scientists on the ISIS muon instruments.Application:EC researchers wishing to use the Facility can apply as part of the normal ISIS procedure for beamtime applications. This requires the completion of the ISIS Beamtime Application Form; there are two calls for experimental proposals in April and October each year. Electronic versions of the application form are available on the World Wide Web (http://www.isis.rl.ac.uk/muons/). Proposals are selected by the ISIS Muon Scheduling Panel, which meets twice per year and is composed of international experts in muon science. The proposals chosen by the Panel are submitted to the IHP management team in Brussels for approval into the Access Programme. Once approval has been granted, proposals are put into the normal ISIS scheduling procedures.Project Manager:Dr. Philip King, ISIS Facility, CLRC Rutherford
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Connecting families with optimal homecare providers through a real-time machine learning matching platform.'.

assistant: **Innovation**

TalentMondo is the world's first skill-based marketplace platform that uses machine learning to optimally match families with homecare providers. TalentMondo makes the traditional and lengthy matching process near instant. It provides both families and homecare providers with optimal, real-time matched results, that adapt to the ever-changing demands of the homecare market. TalentMondo economically empowers both families and homecare providers.TalentMondo is a multisided business that serves two user segments both in need of each other; families and homecare providers. Families include those in need of someone to look after another member, e.g. an elder, a child. Homecare providers include those that provide services to families at the point of need, i.e. at the clients home. These include elderly carers and childminders.We charge a commission for every short-term booking and for every long-term booking made through TalentMondo. We will commercialise through business partnerships that will offer the solution to their workforce. For businesses, TalentMondo will increase productivity and worker satisfaction.In 2016, we were selected as the most innovative technology start-up in Turkey by the prestigious start-up support organization Webrazzi. Since then we have also closed two investment rounds from well-known investors. The prototype of TalentMondo has been successfully tested throughout Turkey with 30,000 families and 3,500 caregivers. We plan to match over 470,000 families with homecare providers, making over €11m in cumulative revenue within 3 years of commercialisation.The proposed project will help us reach this goal by enabling us to optimise the matching algorithm, localise TalentMondo to new markets, undertake a large scale pan-European pilot, as well as scale up
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Environmental transport policies and rural development'.

assistant: **Concept**

This proposal addresses Area 4.6 of the call (Rural Development), in particular Area 4.6.4, focusing on the analysis of the impact of different Community policies on the situation and development of rural areas, and also Area 4.6.3, concerning the constraints on the development of new economic activities in vulnerable rural areas. It involves the development of methodologies concerning the identification and assessment of conflicts and tensions which exist between Community environmental policies affecting transport activities, and the policies for rural development. It uses study areas from five participating countries; Germany, Sweden, Ireland, Greece and the UK. The objectives of the proposed Concerted Action are to develop research methodologies which will allow the following to be carried out: (a) Identification of polices at Community and member states levels, present an planned, and particularly new environmental polices, which affect the economic costs of transport activities, vulnerable rural areas of selected member states, and thus the mobility of people and goods both internally and externally with respect to rural areas. (b) Identification of policies at Community and member state levels, present and planned, for rural development in which the mobility and access of people and goods, both internally and externally, is a significant factor. (c) Assessment of the implications for rural development policy of conflicts between these policy areas. (d) Reflections on the directions in which environmental policy might be modified to allow rural development policies to have maximum effect. The proposed Concerted Action is important for the development of policy in the environmental and rural fields. Methodologies which allow the recognition of tensions between poli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Spurring INnovations for Forest ECosystem SERvices in Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

One of the major challenges relating to the management of Europe’s forests is to balance the provision of distinct forest ecosystem services with broad societal demands. If markets and existing governance arrangements fail, forest owners and managers struggle to meet societal needs. There is a necessity to explore new approaches to connect profitable forest management with changing societal demands. Against this background, innovative mechanisms (IM), including novel policies and business models, have the potential to align ecosystem services supply and demand. SINCERE will, first, systematically map the existing knowledge and practical experiences with IM at the European scale. Second, it will, in a joint effort of practice partners and researchers, design, implement and subsequently evaluate a complementary set of innovation actions that explore novel IM in different regional contexts. These actions encompass a broad spectrum of forest ecosystem services (e.g. biodiversity, climate change mitigation, water supply, recreation), governance mechanisms (e.g. new business models, ‘reverse auctions’ with forest owners, participatory governance) and regional settings (e.g. intensively managed commercial forests in Finland versus little-managed forest land in Spain). Third, a Learning Architecture will connect these innovation actions across countries to incentivize cross-case fertilization and learning between research and practice. Finally, practice partners, policy makers and researchers will jointly draw lessons learnt from the innovation actions, including the upscaling of successful IM to be replicated elsewhere. The project will also push for innovations at the interface between policies and on-the-ground IM, and will deliver concrete suggestions for a coordinated Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Neurophysiological investigation of the mechanisms of long term depression in the rat hippocampus'.

assistant: **Innovation**

A neurophysiological investigation will be carried out on the mechanisms of the induction of long-term depression (LTD) and depotentiation (DP) of glutamatergic excitatory synaptic transmission in the rat hippocampus. The research will concentrate on investigating the role of Ca in the induction of LTD/DP, including the role of the influx of Ca via NMDA receptors and voltage-gated Ca stores in releasing Ca or acting as a sink for Ca during the induction of LTD/DP. The stores that will be mainly investigated are those of the endoplasmic reticulum, and in particular, those which are ryanodine-sensitive and inositol 1,4,5-triphosphate-sensitive. The role of each store will be investigated by measuring the induction of LTD/DP in the presence of selective agents which bind to ryanodine or IP3 receptors and either induce or block release of Ca from the stores.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Equidistribution in number theory' to be submitted under Seventh Framework.

assistant: **Abstract**

The purpose of this proposal is to investigate from various perspectives some equidistribution problems associated with homogeneous spaces of arithmetic type: a typical problem (basically solved) is the distribution of the set of representations of a large integer by an integral quadratic form. Another harder problem is the study of the distribution of special points on Shimura varieties. In a different direction (linked with quantum chaos), the study of the concentration of Laplacian (Maass) eigenforms or of sections of holomorphic bundles is related to similar problems.  Given X such a space and G>L the underlying algebraic group and its corresponding lattice L,  the above questions boil down to studying the distribution of H-orbits x.H (or more generally H-invariant measures)on the quotient L\G for some subgroups H. This question may be studied different methods:  Harmonic Analysis (HA): given a function f on  L\G one studies the period integral of f along x.H. This may be done by automorphic methods. In favorable circumstances, the above periods are related to L-functions which one may hope to treat by methods from analytic number theory (the subconvexity problem).  Ergodic Theory (ET): one studies the properties of weak*-limits of the measures supported by x.H using rigidity techniques: depending on the nature of H, one might use either rigidity of unipotent actions or the more recent rigidity  results for torus actions in rank >1.  In fact, HA and ET are intertwined and complementary : the use of ET in this context require a substantial input from number theory and HA, while ET lead to a soft understanding of several features of HA. In addition, the Langlands correspondence principle make it possible to pass from one group G to another. Based on earlier experience