RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Reversing the epigenetic state of oligodendrocyte precursors cells in multiple sclerosis'.

assistant: **Objectives**

Oligodendrocytes (OL) are glial cells that mediate myelination of neurons, a process that is defective in multiple sclerosis (MS). Although OL precursor cells (OPCs) can initially promote remyelination in MS, this regenerative mechanism eventually fails in progressive MS. OPCs go through several epigenetic states that ultimately define their potential to differentiate and myelinate. OPCs in progressive MS stall in a distinct epigenetic state, incompatible with differentiation and remyelination. We hypothesize that these OPCs regress to an epigenetic state reminiscent of the state of embryonic OPCs, which remain undifferentiated.In this proposal, we aim to uncover the causes behind the remyelination failure upon disease progression in MS. We will determine the epigenetic/transcriptional states of OPCs during development and in MS, using single cell and bulk RNA sequencing and quantitative proteomics. We will further investigate how the interplay between transcription factors (TFs), chromatin modifiers (ChMs) and non-coding RNAs (ncRNAs) contributes to the transition between epigenetic states of OPCs. The results will allow the identification of ChMs and ncRNAs that can modulate these states and thereby control OPC differentiation and myelination. We will use this knowledge to investigate whether we can reverse the epigenetic state of OPCs in MS, in order to promote their differentiation and remyelination. The unique combination of leading-edge techniques such as SILAC coupled with immunoprecipitation and mass-spectrometry, single-cell RNA sequencing, ChIP-Sequencing, among others, will allow us to provide insights into novel epigenetic mechanisms that might be underlying the effects of environmental and lifestyle risk factors for MS. Moreover, this project has the potent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Beyond the Holocene Geomagnetic field resolution' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

For decades the Holocene has been considered a flat and “boring” epoch from the standpoint ofpaleomagnetism, mainly due to insufficient resolution of the available paleomagnetic data. However, recentarchaeomagnetic data have revealed that the Holocene geomagnetic field is anything but stable – presentingpuzzling intervals of extreme decadal-scale fluctuations and unexpected departures from a simple dipolar fieldstructure. This new information introduced an entirely new paradigm to the study of the geomagnetic field andto a wide range of research areas relying on paleomagnetic data, such as geochronology, climate research, andgeodynamo exploration.This proposal aims at breaking the resolution limits in paleomagnetism, and providing a continuoustime series of the geomagnetic field vector throughout the Holocene at decadal resolution andunprecedented accuracy. To this end I will use an innovative assemblage of data sources, jointly unique tothe Levant, including rare archaeological finds, annual laminated stalagmites, varved sediments, and aridplaya deposits. Together, these sources can provide unprecedented yearly resolution, whereby the “absolute”archaeomagnetic data can calibrate “relative” terrestrial data.The geomagnetic data will define an innovative absolute geomagnetic chronology that will be used tosynchronize cosmogenic 10Be data and an extensive body of paleo-climatic indicators. With these in hand, Iwill address four ground-breaking problems:I) Chronology: Developing dating technique for resolving critical controversies in Levantine archaeology andQuaternary geology.II) Geophysics: Exploring fine-scale geodynamo features in Earth’s core from new generations of globalgeomagnetic models.III) Cosmogenics: Correlating fast geomagnetic variations with cosmogenic iso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structure and mechanism of viral and cellular membrane fusion machineries' in the context of a Horizon 2020 call.

assistant: **Objectives**

Fusion of two biological membranes is essential to life. It is required during organism development, for trafficking of material between cellular compartments, for transfer of information across synapses, and for entry of viruses into cells. Fusion must be carefully controlled and the core fusion components are typically found within a complex regulatory machine. There have been decades of research on the structure and function of individual components, on the dynamics and biophysics of fusion, and on phenotypes resulting from mutating or inhibiting component proteins. These have led to a model for fusion in which regulated refolding or assembly of proteins draws two membranes closer together until they fuse. Despite this breadth of study, we know very little about how the components of the fusion machinery function in context: How are they arranged on the membrane around the site of fusion? How do they respond structurally to regulation? How does the fully assembled machinery rearrange to reshape the membrane and drive fusion? These gaps in knowledge can be attributed to a shortage of structural biology methods able to derive structural data on proteins assembled within complex, heterogeneous or dynamic environments such as a fusion site. Here I propose to apply a combination of state-of-the-art cryo-electron tomography, image processing and correlative fluorescence and electron microscopy methods to obtain detailed structural information on assembled fusion machineries and of fusion intermediates both in vitro and in vivo. I will study how influenza virus fuses with a target membrane, complemented by studies on fusion of HIV-1 and of synaptic vesicles. By determining how viral and synaptic fusion complexes reposition and restructure prior to fusion, how they arrange a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Magneto Caloritronics'.

assistant: **Objectives**

MACALO has two main deliverables, one in software and one in hardware which form the core business of the two European high-tech companies in the consortium. The MACALO consortium consists of pioneers of MAgnetoCALOritronics who cover the complete chain from SME start-up company innovation in hardware and software, device simulation and fabrication, benchmark measurements, computational materials science, and basic science, who are committed to employ their expertise to realize the main objectives. The primary goals of MACALO are<br/>1)\tto produce a working prototype of a computer simulation tool to help optimise integrated magnetoelectronic device design parameters at the nanoscale and<br/>2)\tdesign and prototype nano-scale magnetoelectronic RF oscillators with different combinations of desirable properties,  optimisable subsequently (through further company research) for specific applications in wireless communication devices.<br/>Achieving these goals assists replacing the current systems of YIG oscillators, MRAM, and transistors with next generation magnetoelectronic Spin Torque Oscillators, ST-RAM, and transistors by finding material combinations, currently based on suboptimal experimental trial and error systems, using a set of theories, principles, tools and methods that accelerate the development of new devices with improved/optimised properties.<br/>Managing the increased heat and noise in the next generation of electronics is a great challenge. MAgneto CALOitronics (MACALO) addresses the modelling and control of the generation and flow of heat in beyond-CMOS magnetoelectronics circuits and devices. The results are relevant for thermal management of conventional CMOS and novel architectures beyond-CMOS such as low power, low-noise devices, thermally assisted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'CROSS-disciplinary network for research excellence in Regenerative Economy Innovation eco-Systems'.

assistant: **Innovation**

The project aims to raise excellence in science and value creation through deeper and geographically inclusive cooperation in alliance of higher education and research institutions in 5 widening and 4 science-leading European countries, to support the shift towards a regenerative economy paradigm. Global competitiveness and visibility of the HE institutions in widening countries are to be improved by creating critical knowledge and research mass through cooperation with leading European research institutions in the area of the regenerative economy directly aimed towards the twin green and digital transitions. This is to be achieved through clearly defined and measurable sub-goals:-To achieve a more balanced circulation of talents leading to a diverse and inclusive research community and innovative research outcomes, by organising exchanges, short visits and conferences participations;-To reinforce the role of HE institutions in innovative ecosystems, by bringing additional expertise and resources by European leading research-intensive institutions to support the development of innovative ideas;-To mainstream practices and tools for open knowledge and data sharing;-To make progress toward reforming the research assessment system, including career assessment;-To improve links between science and business by providing access to networks, resources and expertise to support the development of business partnerships and collaborations;-To promote gender equality, diversity and inclusiveness;-To accelerate society’s green and digital transition to support ERA Policy Agenda action 11;-To encourage collaboration with third-country entities to support ERA Policy Agenda action 9.The project contributes to the aims of empowering universities as actors of change in R&I by promoting c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Platform-aware Model-driven Optimization of Cyber-Physical Systems' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Many modern industrial systems fall in the realm of Cyber-Physical Systems (CPS) because of the tight interaction between computation, communication and control elements (the cyber part), and physical processes such as motion, heating/cooling, vibration, wear and tear (the physical part) within these systems. Traditional design methods involve multiple, often isolated, design phases involving different disciplines (mechanical, electrical, control and software engineering). Requirements related to cost, quality and reliability enforce designs with over-provisioning of platform resources (computation, communication, memory) by large margins at each phase to be able to fulfill system-level requirements in the worst-case scenarios. To replace such overly conservative design process, there is an urgent need for integrative design trajectories that allow for tradeoffs between cost, quality and reliability coping with the tight coordination between the cyber and the physical components. This gives rise to the need for models that accurately capture the interaction between various components (e.g., software, electronics, mechanics, algorithms, power, energy, etc.) and novel design methods that exploit the artifacts of the underlying platforms. The key scientific objective of the oCPS program is to enable the design of a new generation of cost-effective, quality-driven and reliable CPS by developing model-driven design methods that capture the interaction between different models at various design layers, that take into account physical constraints and processes, and that introduce platform-awareness at all levels. The program aims to train a generation of young researchers in cross-disciplinary thinking and deliver industrially validated tool chains. We bring together the state
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Following a path of breadcrumbs: How fish recognize landmarks during navigation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Reliable vision-based object recognition is of fundamental importance to a wide range of species; however, it can be difficult as the appearance of an object can vary greatly as a result of changes in viewpoint. Recognition during motion presents a particularly challenge as the appearance of an object continuously changes; a particular issue for animals that use landmarks to navigate. One recognition mechanism is to learn a two-dimensional snapshot of an object from a set viewpoint. The object can later be recognized once the appearance of the object matches the stored snapshot. Some animals reduce the number of required snapshots by employing ‘active vision’, where they follow identical routes between landmarks. For fish, the complexity of recognition is compounded by the fact that, unlike surface-bound animals, they can freely move vertically, which could potentially increase the number of approach views to an object. An alternate possibility is that fish have a ‘view invariant’ recognition system and can generalize learned representations of objects so that they can be recognized from different viewing angles. However, high-level visual functions, such as object recognition, are associated with complex mammalian brain structures and may be impossible for animals lacking similar neural circuitry. Despite these problems, we know that fish are capable of navigating efficiently using landmarks. The goal of this project is to investigate how fish recognize visual landmarks during navigation and to determine how they cope with self-orientation related changes in the appearance of objects during motion. Using behavioural experiments, we will test whether fish have view invariant recognition and/or if they employ active vision during navigation. The proposed project will fur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Excelling deep tech through place-based innovation and connected ecosystems for women-led start-ups' under Horizon Europe.

assistant: **Concept**

EPIC-X aims to accelerate and unlock excellence by connecting regional innovation ecosystems across the EU, building on strategic areas of regional strength and specialisation, and addressing the innovation divide and underrepresentation of talents within the European Union. The project enlists a diverse and strong multi-actor interregional ecosystem network that resonates in a Pan-European alliance of interconnected ecosystems. Comprising 16 ecosystem builders hailing from the16 moderate and innovator countries, the basis of this network is set to widely expand to all regions and engage quadruple helix players in collaborative efforts of co-creation, co-implementation, and co-assessment of pioneering acceleration+ programme, which encompasses a FSTP scheme to support deep tech women-led start-ups. Embedded within this comprehensive programme are cross-fertilisation activities and an innovative mobility scheme aimed at the selected start-ups. Ecosystem builders and members of the network will have dedicated opportunities for collaboration and knowledge exchange through tailored actions. With a wealth of experience, the consortium, comprising 13 entities, will spearhead efforts to develop and disseminate materials that underpin a comprehensive communication, dissemination, and exploitation strategy aimed at amplifying the impact of the EPIC-X. This includes the production of a white paper containing policy recommendations and an article/paper to highlight key insights. Built around the three pillars of deep tech, women-led start-ups, and smart specialisation strategies, the project activities and synergies fostered by a multi-layer glocal approach will create a favourable environment for local-placed innovation and sustainable and inclusive growth.


**Keywords:** women-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Responding to the Trend of Human Enhancement Drugs: the Case of Drug-Free Bodybuilding Culture in European Context' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The present project sets out to explore the hitherto uncharted culture of drug-free (‘natural’) bodybuilding that has been emerging in different parts of the world as a response to a dominant, pharmacologically-enhanced model that has thus far monopolised public attention and debate. My aim is to critically investigate the practices, discourses and structures that constitute ‘natural’ bodybuilding and make sense of it in light of a ubiquitous gym/fitness culture and the wider phenomenon of human enhancement. Focusing on Europe as a significant and intriguing site in this emerging global mosaic of body cultures, the research will employ a combination of qualitative methods to trace the development of ‘natural’ bodybuilding across diverse geo-cultural areas of the continent.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.' (MultiSeaSpace).

assistant: **Innovation**

Healthy ecosystems are productive and resilient to climate change.  However, their conservation through ecosystem based management remains a challenging task. This is due to a lack of understanding of both the many complex interactions among all the components within the ecosystem and the impact of management action on their health. Hence, successful conservation relies on studies that use suitable data collection methods and appropriate statistical modelling approaches that reflect this complexity and help predict the impact of different management actions. Collecting data on species in marine ecosystems is particularly challenging as the marine environment is largely inaccessible and species are mostly invisible to researchers. Surveys can typically only collect information on some aspects of the distribution of individuals in space, mainly in dependence on the behaviour of a specific species within space and practical limitations. As a result, different sampling methods have been used, resulting in different data structures (e.g. point-process data, line transect data, telemetry data, fishery acoustic data, point-pattern data). Separate statistical modelling approaches along with different software packages have been developed for each of the different survey data structures.MultiSeaSpace seeks to develop an integrated general spatial modelling strategy that allow us to integrate different sampling methods in a unified modelling framework that include trophic interactions. This unification provides a huge advantage since it: (a) allows us to operate within the same framework, avoiding the use of different software packages, facilitating comparison; (b) allows the pooling of information across different surveys, even if these resulted in different data structures; (c)