RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Identifying factors of resistance and susceptibility to dengue virus infection in Aedes aegypti mosquitoes'.

assistant: **Innovation**

Emerging infectious diseases represent a global health problem, as demonstrated by the Covid-19 pandemic. Among them, viral pathogens transmitted by mosquitoes represent a growing threat to human health, due to global warming and globalization. For example, Aedes aegypti mosquitoes are the main vectors of dengue viruses that infect 400 million people annually. However, major knowledge gaps remain in our understanding of interactions between mosquitoes and viruses. For example, the mechanisms underlying natural variation in susceptibility to viral infection between different mosquito populations remain mostly unknown. My project aims to address this question using novel methods combining single-cell transcriptomics and metabolomics approaches. First, I will identify Ae. aegypti mosquito populations that are highly or poorly susceptible to infection with dengue viruses. Next, I will analyze infection dynamics in key mosquito organs: the mosquito midgut, which is the entry point for the virus, and the fat body which regulates metabolism. I will analyze their response to virus infection using single-cell transcriptomics and metabolomics. A joint “multi-omics” analysis of both datasets will describe, for the first time, the metabolic functions of different cellular subpopulations of the mosquito midgut and fat body upon dengue infection. It will reveal the metabolic pathways and gene expression patterns that are associated with susceptibility towards virus infection at the cellular level. Finally, the contribution of these candidate genes and metabolites to susceptibility or resistance to infection will be validated using functional assays (e.g., chemical inhibition, gene knockdown) in vivo. This project will address an important knowledge gap in virus-mosquito interactions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dynamic Combinatorial Chemistry - selection based approach to catalysis' under Sixth Framework.

assistant: **Concept**

Dynamic Combinatorial Chemistry is proving to be a powerful tool in the search for new host-guest systems. A dynamic combinatorial library consists of a mixture of compounds made by connecting building blocks through reversible covalent linkages. Addition of a template (host or guest) shifts the equilibrium in favour of a strongly binding partner at the expense of other library members. By this means a very large number of compounds are screened, and simple analytical techniques can determine suitable matc hes for the template. In the case where the template is a transition state analogue for a given reaction the host(s) produced would be expected to act as catalysts (transistion state stabilization). In this way the system itself selects the potential cata lysts and drives their synthesis. This will be exploited in the proposed research, where catalysts will be sought out through selection based methods, starting with ester hydrolysis and advancing to asymmetric catalysis and peptide cleavage.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transforming the future of agriculture through synthetic photorespiration' (FutureAgriculture) targeting Horizon 2020.

assistant: **Abstract**

For a new green revolution to feed the continually increasing population, agriculture productivity will have to be significantly improved. Photorespiration represents a big challenge in this respect, because it dissipates energy and leads to the futile loss of CO2, thereby limiting plant growth yield. Implementing an efficient metabolic bypass for photorespiration can therefore increase the photosynthetic efficiency of many cultivated crops. Several such routes were previously proposed. However, these routes were limited to existing enzymes and pathways and provided only partial improvement. Here, we propose a radically different approach: to engineer entirely novel CO2-neutral or CO2-positive photorespiration bypasses based on novel enzyme chemistry that support significantly higher agricultural yields. These bypass routes could support 60% higher biomass yield per turn of the Calvin Cycle and >30% higher yield per ATP. Our project innovatively integrates different research disciplines and combines academic research with industrial implementation. In silico studies will integrate biochemical logic and pathway modelling to explore all possible photorespiration pathways and identify the most efficient routes. In vitro research will establish novel enzyme functions via enzyme engineering and directed evolution. Full pathways will be reconstituted and optimized in vitro using a novel mass spectrometry based platform. High in vivo activity will be selected by implementing the pathways in engineered E. coli strains. Enhanced photosynthetic efficiency will be demonstrated in cyanobacteria expressing the synthetic pathways. Finally, the most promising synthetic pathways will be implemented in higher plants and growth phenotypes will be monitored. The proposed project comprises
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A wireless network with autonomously powered and active long range acoustic nodes for total structural health monitoring of bridges' to be submitted under Seventh Framework.

assistant: **Abstract**

Wireless sensor networks have been identified as a research priority by the European Technology Platform on Smart Systems Integration (EPoSS). Recognising this, the SME's in this Project are seeking EC funding to develop a prototype wide-area wireless sensor network with autonomous nodes containing non-destructive (NDT) sensors, for structural health monitoring (SHM) of large structures, specifically bridges and vessels in petrochemical plant. They have formed a consortium with expertise in a range of technologies needed to optimise solutions and develop this innovative new product.The aim is to develop an NDT node that is autonomous and self-configuring for optimal performance, and requires no maintenance over its operating life. The nodes will be packaged for reliable operation in hazardous environments and will rely on energy harvesting to provide long-term power supply. The wireless communications will allow simple place-and-play usability. The NDT techniques to be implemented are long range ultrasonics for global monitoring of a structure, ACFM for local surface corrosion and cracks, pulse-echo ultrasonics for internal corrosion and tip diffraction ultrasonics for internal cracks. The prototype will show scalability up to very large structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Turning oil into stone: Oil legacies in the narratives  of urban continuity and change in Baku, Azerbaijan' (BAKOIL) targeting Horizon 2020.

assistant: **Abstract**

This research project will explore the construction of ‘oil city’ narratives in Baku, Azerbaijan. Baku is one of the earliest and historically most significant oil cities in the world. Despite this important legacy, there has been little scholarly attention to the ideological and cultural meanings of oil in different urban milieus. Addressing this gap in scholarship, this study aims to deepen scholarly understanding of the constitution of oil urbanism and its implications for post-oil future. The development of many cities that are linked to oil production is dependent upon the economic cycles of boom and busts of the industry. Typically, oil cities rapidly grow during a boom, and decline during a bust. Few cities are able to reinvent themselves after a bust, either by diversifying their economies or assuming the role of a technological hub for the industry. Baku is unusual among the world's oil cities, as it neither declined nor reinvented itself, but has perpetuated its dependence on oil for the last 150 years and continued to strengthen its identity as ‘the oil city’. Using a combination of ethnography and textual analysis, this study aims to provide a detailed ethnographic analysis of how Baku’s oil city identity has been constructed and reproduced in official and unofficial discourses by variously positioned professionals involved in memory-making, either directly (museum workers and urban heritage activists) or indirectly (oil industry professionals; city planners; tour guides). The main research objectives are: 1) to examine the official and unofficial narratives of urban continuity based on oil production in their socio-cultural context 2) to explore the practices of collective remembering and forgetting in constructing the narratives of Baku as a historical cen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Stabilizing pharmaco-active Membrane proteins with Zwitterionic polymers and leveraging Surface Plasmon Resonance as an Analytical platform'.

assistant: **Objectives**

Membrane proteins, particularly G-protein-coupled receptors (GPCRs), represent 25-30% of current drug targets. Among them, metabotropic glutamate receptor (mGluR), a Class C and group 1 type GPCR, is emerging as an attractive therapeutic target for various neurological and psychiatric disorders such as Alzheimer’s disease, Parkinson's disease, autism spectrum disorder, schizophrenia, and neuropathic pain. Despite the availability of its complete structure, biophysical characterization and drug discovery efforts targeting mGluR have been hindered by the challenges in obtaining stable, active conformations of this receptor for in-vitro studies. To overcome this impediment, we will utilize amphiphilic zwitterionic polymers, for stabilizing mGluR. Carefully synthesizing copolymers can mimic the native lipid environment and maintain the receptor's structural and functional integrity. Zwitterionic polymers, with their unique molecular architecture featuring both anionic and cationic groups, structure surrounding water molecules, creating super-hydrophilic surfaces ideal for stabilizing membrane proteins with exposed hydrophobic domains.To evaluate this stabilization strategy, we first aim to employ the label-free bio-analytical technique of surface plasmon resonance to immobilize the mGluR-polymer complex. Secondly, we will investigate binding kinetics, affinities, and allosteric modulation of mGluR1 receptor to obtain valuable insights into protein-drug interactions. We anticipate this innovative strategy will address the existing challenges in stabilizing mGluR, offering improved stability, reduced complexity, cost-effectiveness, and higher yields over conventional methods. Moreover, it will accelerate drug screening practices targeting mGluR and other challenging membrane
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Multi-photon probing of complex open quantum systems'.

assistant: **Concept**

In this Marie Sklodowska-Curie action we explore the prospects of controlled multi-photon scattering processes as a probe of the nonlinear interactions and the dynamics of complex open quantum systems. The core of the project builds around the development of novel analytical and numerical tools to model complex scattering processes under correlated noise and dissipation. The project is thus mainly theoretical, but it is also interdisciplinary and focuses on problems and setups that admit immediate experimental implementations in a variety of state-of-the-art platforms, such as superconducting qubits coupled to microwave photons in transmission lines or quantum emitters coupled to photonic crystal waveguides. Moreover, the techniques and ideas that we will develop should be essential for the understanding and control of light-matter interactions in the multi-photon regime, as well as for the engineering and modelling of new and robust photon-based quantum technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'PReparing Industry to Privacy-by-design by supporting its Application in REsearch'.

assistant: **Innovation**

The mission of PRIPARE is twofold: facilitate the application of a privacy and security -by-design methodology that will contribute to the advent of unhindered usage of Internet against disruptions, censorship and surveillance, support its practice by the ICT research community to prepare for industry practice; foster risk management culture through educational material targeted to a diversity of stakeholders. To this end PRIPARE will\tspecify a privacy and security-by-design software and systems engineering methodology, using the combined expertise of the research community and taking into account multiple viewpoints (advocacy, legal,  engineering, business),\tprepare best practices material (guidelines, patterns, success stories) for the development and implementation of products and services of ICT-based systems and use-cases in the area of cloud computing, mobile services and the management of cyber incidents,  \tsupport FP7 and Horizon 2020 research projects through training workshops and practical support in applying PRIPARE best practices in their environment.\tprovide educational material on approaches for risk management of privacy and create awareness on the need for risk management culture among users. Material consistent with PRIPARE methodology will be structured in a modular way in order to fit to different targets (policy makers, users, ICT students and professional). \tidentify gaps and provide recommendations on privacy and security-by-design practices, support of unhindered usage of Internet and on the creation of a risk management culture. A research agenda will be proposed.PRIPARE consists of a consortium of 11 partners with strong links with the privacy community (data protection authorities/policy makers, privacy advocacy organisations, techno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Automotive drive using pneumatic batteries with oilhydraulic interface and fast refilling permormances' (1994-1998) under Fourth Framework.

assistant: **Objectives**

All the analysis of the environmental, social and e.onomic aspects have shown that a non-polluting car is needed to limit local nuisance concentration and global CO2 unbalance, particularly in cities. The aim of the project is to overcome the deadlock of electro-chemical energy storage, to finally be able to develop a zero pollution pneumatic vehicle. This goal should be achieved by the development of new interfaces which would allow to store energy in compressed air with efficiencies similar to state of the art battenes. The thermodynamic efficiency barrier will be torn down by the use of oil as intermediary fluid combining the three needed functions of thennal inertia, caloric transportation and internal slow movement multiplication. We will get as a result a battery containing no aggressive chemicals and hence easily recyclable, with user benefits of fast refilling, accurate metering of deliverable energ! and temperature insensitivity. These works could finally make it possible to open the market of the zero pollution car and, for European car manufacturers, to deeply modify their world-wide market positions. The exploratory phase showed that the BOP should easily compete with EVs in price, energy-to-weight ratio, life expectancy and recycling capacity. This market addresses the ZEV market which is valued to 232 000 vehicles in Europe per year (2% of registrations per year). The objective for BOP is to obtain 5 to 10 ° % of this market which would generate a 29 to 58 million ECU revenue per annum for Automotive On Board Equipments only: these figures do not take into account the revenues from infrastructure, vending systems, etc... The proposers will benefit in two ways from the BOP vehicle programme thanks to the opening of a new and individually unattainable market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'From Flat to Chiral: A unified approach to converting achiral aromatic compounds to optically active valuable building blocks' to be submitted under Seventh Framework.

assistant: **Abstract**

The stereoselective preparation of enantioenriched organic compounds of  high structural complexity and synthetic value, in an economically viable and expeditious manner, is one of the most important goals in contemporary Organic Synthesis. In this proposal, I present a unified and conceptually novel approach for the conversion of flat, aromatic heterocycles into highly valuable compounds for a variety of applications. This approach hinges upon a synergistic combination of the dramatic power of organic photochemical transformations combined with the exceedingly high selectivity and atom-economy of efficient catalytic processes. Indeed, the use of probably the cheapest reagent (light) combined with a catalytic transformation ensures near perfect atom-economy in this journey from flat and inexpensive substructures to chiral added-value products. Conceptually, the photochemical operation is envisaged as a energy-loading step whereas the catalytic transformation functions as an energy-release where asymmetric information is inscribed into the products.The chemistry proposed herein will open up new vistas in enantioselective synthesis. Furthermore, groundbreaking and unprecedented methodology in the field of catalytic allylic alkylation is proposed that significantly expands (and goes beyond) the currently accepted “dogmas” for these textbook reactions. These include (but are not limited to) systematic violations of well-established rules “by design”, new contexts for application, new activation modes and innovative leaving groups. Finally, the comprehensive body of synthetic technology presented will be applied to pressing target-oriented problems in Organic Synthesis. It shall result in a landmark, highly efficient total synthesis of Tamiflu, as well as in application to a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovation driven Collaborative European Inland Waterways Transport Network' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

IW-NET will deliver a multimodal optimisation process across the EU Transport System, increasing the modal share of IWT and supporting the EC’s ambitions to reduce transport GHG emissions by two thirds by 2050. Enablers for sustainable infrastructure management and innovative vessels will support an efficient and competitive IWT sector addressing infrastructure bottlenecks, insufficient IT integration along the chain and slow adoption of technologies such as new vessel types, alternative fuels, automation, IoT, machine learning. The Living Lab will apply user-centered application scenarios in important TEN-T corridors demonstrating and evaluating the impacts in simulations and tests covering technological, organisational, legal, economical, ecological, and safety/security issues: 1) Digitalisation: optimised planning of barge operations serving dense urban areas with predictive demand routing (Brussels-Antwerp-Courtrai-Lille-Valenciennes); data driven optimisation on navigability in uncertain water conditions (Danube).2) Sustainable Infrastructure and Intelligent Traffic Management: lock forecasting reducing uncertainty in voyage planning; lock planning; management of fairway sections where encounters are prohibited; berth planning with mandatory shore power supply and other services (hinterland of Bremerhaven via Weser/Mittelland Canal).3) Innovative vessels: new barge designs fitting corridor conditions and target markets: barges with a high degree of automation for urban distribution (East Flanders-Ghent); new barge for push boats capable with low/high water levels optimising capacities (Danube from Austria to Romania); use of GALILEO services for advanced driver assistance like guidance, bridge height warning and automatic lock entering (Spree-Oder waterway close to