RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Computational discovery and design of disease-beating nutrition' (Hyperfoods) under Horizon 2020.

assistant: **Objectives**

With rapidly ageing populations, the world is experiencing an unsustainable healthcare and economic burden from chronic diseases such as cancer, cardiovascular, metabolic and neurodegenerative disorders. Diet and nutritional factors play an essential role in the prevention of these diseases and significantly influence disease outcome in patients during and after therapy. Everyday food ingredients contain multiple drug-like molecules that can potentially prevent or beat diseases. For example, it is estimated that up to half of oncological diseases can be prevented by dietary choices. The wide adoption of tailored health-promoting diets potentially has a revolutionary impact on the population wellbeing and long-term sustainability of the healthcare systems. However, due to an exponentially large number of combinations of the ingredients, their sourcing, processing, preparation, and preservation methods, it is virtually impossible to use traditional experimental approaches to optimise the health-promoting molecular profiles of foods. Hyperfoods will use novel graph-based ML methods to provide the technological capabilities for the computational discovery and design of personalised nutrition. We will explore the commercial opportunities of our technology for currently unmet business needs in global health, in particular cancer treatments.


**Keywords:** geometric deep learning, graph ML, precision nutrition, digital therapeutic, cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A next generation high level sensing system to enable safe and high level automation of industrial vehicles.' (2021-2027) under Horizon Europe.

assistant: **Objectives**

The problem with todays autonomous system architectures is that minimal changes in the camera alignment of less than 1 mm can lead to significant misalignments and invalidate measurements of the surrounding environment, leading to major safety concerns in autonomous vehicles. Tripleye has invented the COP (Circular optical perception) to solve this issue. The COP is a next generation camera only computer vision system that uses proprietary algorithms (named KIEV and RubberStereo) together with a fisheye camera to triangulate and capture high level 3d spatial components needed for advanced automation. Specifically, COP offers a revolutionary solution for the safe and efficient operation of earthmoving, material handling, and automated guided vehicles. During the proposed EIC project, Tripleye will look to upgrade its software stacks, integrate the system into material handling/earth moving machines in a real working environment for iterative testing.


**Keywords:** Earthmoving,Material Handling,Computer Vision,3D Sensing,Vehicle Technology,Autonomous driving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design, construction and demonstration of solar biofuel production using novel (photo)synthetic cell factories' to be submitted under Seventh Framework.

assistant: **Abstract**

CyanoFactory brings together ten selected leading, highly complementary European partners with the aim to carry out integrated, fundamental research aiming at applying synthetic biology principles towards a cell factory notion in microbial biotechnology. The vision is to build on recent progress in synthetic biology and develop novel photosynthetic cyanobacteria as chassis to be used as self-sustained cell factories in generating a solar fuel. This will include the development of a toolbox with orthogonal parts and devices for cyanobacterial synthetic biology, improvement of the chassis enabling enhanced growth and robustness in challenging environmental conditions, establishment of a data warehouse facilitating the modelling and optimization of cyanobacterial metabolic pathways, and strong and novel bioinformatics for effective data mining. To reach the goal, a combination of basic and applied R&D is needed; basic research to design and construct the cyanobacterial cells efficiently evolving H2 from the endless resources solar energy and water, and applied research to design and construct the advanced photobioreactors that efficiently produce H2. Biosafety is of highest concern and dedicated efforts will be made to address and control cell survival and death. The aim, to develop a (photo)synthetic cell factory, will have an enormous impact on the future options and possibilities for renewable solar fuel production. The consortium includes academic, research institute and industry participants with the direct involvement of two SMEs in the advanced photobioreactor design, construction and use. Purpose-designed, specifically engineered self-sustained cells utilising solar energy and CO2 from the air, may be the mechanisms and processes by which we generate large scale re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A new technology of microthermal sensing for application in microcalorimetry'.

assistant: **Concept**

ANTS aims to prove the viability of a novel thermal microsensor, with highly improved thermal, temporal and spatial resolution, to be the basis of a breakthrough micro/nano-calorimeter. The resulting device shall quantify binding rates and enthalpy/entropy changes in interactions of biological interest in a much more accurate and straightforward manner than available techniques. Consequently, ANTS-microcalorimeter will facilitate enormously drug discovery and development of biomedical products and technologies. We propose to exploit the large Nernst effect in ferromagnetic conductors for electrical sensing of temperature gradients with exceptional sensitivity. The active sensing elements are composed of a single material, thus offering important advantages for miniaturization over conventional micro-calorimetry, based on diverse Peltier modules, whereas easy to fabricate by standard, scalable deposition and photolithographic methods. Standard microcalorimeter configuration can also be maintained in the novel device, which is convenient to ensure compatibility and foster adoption by users and manufacturers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Satellite based operation and management of local low traffic lines (SATLOC)' (SATLOC) under Seventh Framework.

assistant: **Objectives**

The project addresses the development of innovative GNSS Safety of Live (SoL) application in the train control speed supervision, train control and traffic management of low traffic lines (LTL). The application contributes to the adoption of EGNOS as a precursor and to the introduction of Galileo in the rail safety related domain. Application is in a broad context since it introduces the GNSS train positioning and speed determination with SoL characteristics in all critical operations of a railway line. The project includes the development and integration of new concept, software, hardware, services and datasets compatible with the current evolution of the rail signalling and rail standards. The selection of LTL application demonstrates the complementarity and migration to the ETCS when GNSS is applied in a holistic approach.Overall objective:Develop and demonstrate by real train operation the innovative concept of applying the GNSS SoL to railway safety and produce advanced operation on low traffic lines and hence:• Stimulate adoption of EGNOS within new innovative rail operation with important market impact and with important effects on socio-economic, mobility and environment;• Prepare markets for Galileo introduction since EGNOS is the precursor of GALILEO. Enablers will be created including the awareness and preparation of the railway operations to immediately apply the new system;• Stimulate EU GNSS industry competitiveness in domains which are reputed (railway safety, railway integrated operations) for using mostly traditional ground-based technologies and conservative for global approach. The railway industries and the satellite navigation industries will cooperate.The overall result is the full specification, applied technology and live demonstration – to creat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Insertional mutagenesis in xenopus'.

assistant: **Objectives**

Research objectives and content Objectives. The Amphibian embryo is one of the best systems for elucidating the mechanisms of early development. While the advantages of this system are numerous, one major disadvantage is that it has not been possible to manipulate the system at a genetic level. The aim of this proposal is to bring genetics to the frog, Xenopus. To this end we propose to develop a method for performing insertional mutagenesis in the frog embryo. Background and Significance. Our understanding of the molecular mechanisms of induction and patterning of the early vertebrate embryo has largely come from experiments in the frog. Indeed. the amphibian embryo is large and accessible allowing its manipulation with accuracy and ease. In addition, one can missexpress genes of interest in the early embryo by microinjecting in vitro transcribed RNAs. Recently Dr. Amaya's group at the Wellcome/CRC Institute in Cambridge has improved our ability to manipulate gene expression by developing an efficient method of generating transgenic frog embryos Briefly, this method involves integrating DNA into isolated sperm nuclei in vitro followed by their transplantation into eggs Because DNA integration occurs before fertilisation, the resulting transgenic embryos are not chimeric and breeding is not required. This technique allow gene function studies in the frog using genetic approaches and one can now monitor the temporal and spacial expression of the gene of interest in the embryo with high precision. Although useful. these methods have the disadvantage that they involve missexpression and/or gain of function experiments. The alternative loss of function experiments in the frog are usually restricted to the expression of dominant negative mutants which are rarely specific to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ecotoxicological relevance of leaching processes in solid residues exposed to freshwater model ecosystems', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The environmental relevance of solid residues is described by their leach ability and toxicity. Short-term leaching tests and bioassays have been developed to assess their initial leaching and direct effect. Criteria set up for their reuse or disposal is based on these test schemes. However we are still uncertain to translate the obtained laboratory data into real" systems. Main objective of the proposed study is to describe the significance of leaching processes for whole ecosystems. For this reason, multi-species test systems are proposed here for the first time to study the complex interaction between leaching processes and the biota. In contrast to single-species tests, these systems show a high degree of realism, in terms of size, diversity and food web interactions. It will be possible to identify indirect and secondary effects, which may be overlooked by conventional test procedures. This will help to develop environmentally more safe recycling products and applications."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improving organoleptic quality of african robusta coffee through marker assisted selection', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Due to its low flavour and high bitterness, Robust coffee (Coffee canephor),produced in African lowlands, is less appreciated by consumers than Arabic. An improvement of its cup quality will increase its price and then lowland coffee growers' incomes. Coffee flavour is the result of very complex reactions which occur during roasting. Sucrose and trigonelline give positive flavour coumpounds, where as chlorogenic acids and caffeine increase bitterness. This project focuses on the development of Marker Assisted Selection (MAS) for improvement of Robust coffee organoleptic quality. Markers linked to genes involved in the metabolism of taste and aroma precursors will be looked for in order to carry out early selection in progenies .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Affordable digital fly-by-wire flight control system for small commercial aircraft' under Fourth Framework.

assistant: **Concept**

Objectives and content The goal of this project is to develop an architecture for a an affordable fly-by-wire (FBW) digital flight control systems (DFCS) for small commercial aircraft, while utilising advanced technologies such as Fuzzy/Neural and robust control algorithms which will reduce the cost of the system development and the operational cost of the aircraft. Currently the FBW-FCS technologies are used mainly in fighter aircraft and large civil transport/cargo jets. The objective is to evaluate the affordability and cost effectiveness of incorporating these technologies in small civil aircraft. The possibility to reduce the complexity of the control algorithms and the redundancy management in the system will be evaluated, using two main methodologies: the conventional/robust control and the Fuzzy/Neural control. If successful, the outcome of this project, which is scheduled for three years, will include clear recommendations as for the affordability of the FBW-DFCS technology to small civil jets. In addition, a detailed description of the required technologies and design methods needed to achieve the affordable and costeffective solutions will be presented. The main achievement of the ADFCS project will be the definition of a FBW-DFCS which will provide preferred automatic control solutions for small jet aircraft, including a clear design methodology for constructing and incorporation of the FCS onto an existing aircraft and especially, on a new designed aeroplane. The emphasis is on obtaining enhanced affordability of FBW-DFCS compared to the common conventional mainly mechanical systems implemented today in small aircraft. The major innovation will be the application of robust control law design techniques, partially based on fuzzy logic and neural networks, in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of gene therapy and genome editing strategies to treat adenosine deaminase 2 deficiency' (DADA2GT).

assistant: **Innovation**

Deficiency of adenosine deaminase type 2 (DADA2) caused by loss-of-function mutations in the ADDeficiency of adenosine deaminase type 2 (DADA2) caused by loss-of-function mutations in the ADA2 gene is a Primary immunodeficiency (PID) diseases characterized by vasculopathy, stroke, intracranial haemorrhages, systemic inflammation, immunodeficiency, and cytopenia. Without proper treatment, DADA2 patients are at high risk of severe disability or death. Targeted pharmacological therapies are not available, and generic immunosuppressive drugs are commonly used with unsatisfactory effectiveness. Haematopoietic stem cell transplantation (HSCT) has proven effective in patients with severe manifestations, but morbidity and mortality are high and hardly acceptable in less severe cases. Thus, safer and targeted therapeutic options for these patients need to be rapidly developed. Based on the observation that HSCT can be successful, it is reasonable to presume that strategies based on ADA2 correction in autologous haematopoietic stem/progenitor cells (HSPCs) may provide new targeted therapeutic approaches for DADA2. The main goal of this project is to establish gene therapy as a new therapeutic option for DADA2. We propose: i) to develop a pre-clinical approach of gene addition mediated by lentiviral vectors targeting ADA2 expression in patient HSPCs; ii) to exploit gene-editing technologies to prove their efficiency for correction of ADA2 mutations. Gene correction efficacy will be assessed as ADA2 expression and activity in vitro in HSPCs and iPSCs isolated from patients, and in mice humanized with patients’ HSPCs. Collectively, this proof-of-concept study will provide new and robust pre-clinical data for the application of lentiviral-mediated HSPC gene therapy in DADA2. This inn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Designing the I-Do Service: Facilitating Inclusion and Empowerment of People Living with Dementia through Access to Cultural and Creative Activities' (IDoService), addressing dissemination and exploitation.

assistant: **Impact**

This fellowship will co-develop, implement and evaluate the I-Do service to increase the socio-cultural participation and empowerment of people living with mild to moderate stages of dementia (PLWD) through an interdisciplinary engaged research approach that combines service design and psychology with a co-design methodology. This user-friendly service will allow PLWD to plan, connect with and participate in tailored opportunities to realise themselves and contribute to society. The fellowship will use a co-design approach (Niedderer et al. 2019), working with PLWD, their relatives/familial carers as well as relevant stakeholders. It will develop the service model, i.e. the principles for format, content and delivery of the I-Do service, which it will implement and evaluate through a pilot in the area of Manchester, UK. The I-Do service addresses a key need of PLWD to be able to contribute and to be valued for it: Tournier et al 2017 found that PLWD are looking for more self-determination, to conduct activities on their own, to continue to learn new things and to be creative as well as to feel useful to others. This corroborates an investigation by Schölzel-Dorenbos et al. (2010) on this understudied topic, which shows that social contact, attachment, being useful/giving meaning to life, enjoyment of activities, and self-determination and freedom are key aspects of unmet needs for PLWD. I-Do will address these unmet needs through its novel interdisciplinary engaged community approach to develop the understanding of relevant and appropriate services for PLWD and to support the realisation of local and national policies regarding dementia friendly communities in the UK.


**Keywords:** dementia, service design, social inclusion, empowerment