RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Direct reaction models for exotic nuclei', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This proposal provides a targeted research programme to put in place state-of-the-art analysis techniques for nuclear reactions induced by beams of exotic nuclei. The specific scientific objectives address two areas of current and future interest to the lo w-energy nuclear reactions community; the reactions of weakly bound exotic nuclei and the trade-off between direct break-up and transfer reactions (to be applied specifically to the interaction of 6He with a 208Pb target) and the development of a modern mod us operandi for the analysis of (d,p), (d,n) and (p,d) single nucleon transfer reactions, valuable tools for probing single particle aspects of the structure of exotic nuclei.Wider aspects of the programme address the scientific excellence of the EU through the development of state-of-the-art analysis tools for nuclear reactions with exotic beams, thus increasing the attractiveness of Europe for researchers in this field by providing training opportunities in the use of these tools. Training benefits from the programme are twofold; for myself, the opportunity to broaden my expertise in nuclear reaction analysis techniques and investigate new lines of research, for others, the opportunity to learn up-to-date analysis techniques that will ensure that new data are fully exploited.The pan-European dimension of the programme will enable me to form part of a dynamic experimental group in an EU-member country other than my own, facilitating a two-way exchange of benefits; working within an experimental group actively engaged in the area of nuclear reactions with exotic beams will increase my awareness of current experimental possibilities and interests. Conversely, this will also provide in house analysis of data with the most up-to-date methods for the host group and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Small ribonucleic acids in silico' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Ribonucleic acid (RNA) is acquiring a larger importance in cell biology, as more functions that it accomplishes are discovered. In particular, as it has emerged in the last decade, it has a crucial role in the post-transcriptional regulation of gene expression. The comprehension of these mechanisms and, in general, of RNA properties at a molecular level is a key issue in the study of many diseases and paves the way to possible applications in molecular medicine. Particularly interesting in this context are riboswitches, small portions of messenger RNAs which change their conformation in presence of specific metabolites and consequently inhibit or enhance gene transcription or translation. Another issue of paramount interest is RNA metabolism, crucial for viral replication, and in particular of the interaction of RNAs and the molecular motors devoted to its manipulation and unwinding. One of the goals of the present project is to develop new in silico approaches based on molecular dynamics for the study of small RNA molecules. In particular, the research will focus on (a) the development of ad hoc techniques to accelerate molecular dynamics simulations of RNA and of RNA-protein complexes and (b) to predict the three-dimensional structure of small RNAs. Another major goal of the present project is to apply the aforementioned techniques, in combination with standard molecular dynamics and state-of-the-art rare-event methods, to the study of three extremely relevant topics: (a) the interaction between RNA and the helicases, which are the enzymes devoted to its unwinding in the cell, (b) the conformational transitions in riboswitches, and (c) the structure of non-coding inverted short interspersed elements (SINE).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Neighbourhood interventions, and social and ethnic mix: the tackling of urban inequalities'.

assistant: **Innovation**

The research aims to investigate whether, and how, in a Southern European context area-based programmes in deprived and ethnically diverse neighbourhoods effectively decrease socio-spatial inequalities at neighbourhood and city level; and whether more equal opportunities and access to resources have emerged, fostering the upward social mobility of the different social and ethnic groups. It will first develop a theoretical and conceptual framework for the analysis of the impacts of area-based and mixed community programmes from a redistributive perspective and within a multi-scalar thinking. Drawing on different European cases, it will intersect current international debates on social cohesion (e.g. urban inequality and segregation, local welfare system, and diversity), focusing on inequality of opportunities within the remit of social mobility and neighbourhood (de-)commodification. The multidimensional framework will then be applied to two neighbourhood case studies in Barcelona to assess the social and spatial effects of the PERI renewal programmes on the long-term residents and the wider consequences at neighbourhood and city level. Quantitative and qualitative longitudinal analyses will look at changes in housing, professional, educational, and demographic indicators and their geography (1986-2011) and interpret their correlations within the broader social and urban transformations of the city. Qualitative analysis of few paradigmatic social and ethnic groups will investigate processes of social and spatial mobility in relation to changes in socio-economic opportunities (production: i.e. employment, training), access to resources (consumption: i.e. public services, public spaces, housing affordability/progression) and neighbourhood affordability. Finally, reflection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The contribution of multinational retailers from developed countries operating in developing economies to the export performance of local firms' (MULTIRETAIL), addressing dissemination and exploitation.

assistant: **Impact**

The current project seeks to answer how the overseas expansion of multinational retailers impacts the capacity of local (host country) firms to export. It focuses on multinational retailers from developed countries that establish operations in developing economies. In terms of theoretical modeling, it intends to add a retail sector in trade models with heterogeneous firms, and to unravel the link between the evolutions in the retail sector and the distribution of firms' productivity in the host country. For the empirical part, the integration of several host countries in the analysis and the use of firm-level data is intended in order to accurately measure the capability effect (the increase in exports due to productivity improvements of local firms), the linkage effect (the increase in exports due to the access of local firms to retailers’ foreign networks of outlets and contacts), as well as reveal new underlying mechanisms at work. Another objective of the project is to disentangle between effects on exports towards traditional and new foreign markets, and to evaluate the impacts in terms of the variety of goods produced and exported by host country firms. Finally, the project aims to understand how multinational retail chains adjust their supply policies to production shocks faced by their suppliers, and how these decisions explain retailers' trade-offs between low-cost suppliers from developing countries, and more reactive, more flexible suppliers from home and other developed economies. This is an innovative approach, because the existing literature focuses exclusively on firms’ responses to changes, shocks in the demand, emphasizing their focus on policies ensuring just-in-time delivery.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fundamental Aspects of Developmental Plasticity of the Cerebral Cortex : Implications for Neurological Disease' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

- To examine the early laminar and areal commitment of cortical progenitor cells in the rodent and in the primate as well as the origin of the instructions to the precursors.- To investigate the role of thalamic afferents in the specification of the identity of cortical areas in the primate.`- To determine the potentiel of neurotrophins to influence the specification of cortical areas and the formation of functional connections. The aim of the present proposal is to advance our understanding of the role of environmental factors in the three major stages of corticogenesis. First, the six layers of the cortex are generated by processes of cell proliferation, migration and differentiation. Here the early laminar and areal commitment of progenitors will be examined. Second, the newly formed cortex establishes connections both between areas and with subcortical structures. Here the role of thalamic afferents in the specification of the cortex will be studied. Third there is a period of refinement of connections during which the electrophysiological properties of the cortex emerge. Here the potential of neurotrophins to influence the formation of functional connections will be assessed. A particular effort will be made to progress in the understanding of the theoretical basis for future therapeutic procedures. This will be achieved by (i) focusing on those aspects of environmental control which are heavily implicated in the developmental neuropathology of the cortex and (ii) by pooling our resources, it will be possible to establish a primate model of cortical development.  Two complementary experimental approaches will be undertaken: (i) A reductionist approach where the origins and effects of extracellular signals that determine the areal and laminar fate of cortical precur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'REFRESH - Relate, Experience, Find Research Everywhere and SHare' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

REFRESH (Relate, Experience, Find Research Everywhere and SHare) is a 20-month project led by Centre for Research & Analysis with 20 partners and 27 associates. The Consortium includes 14 academic institutions, Bulgaria’s only tech park, a chamber of industry and commerce, the local office of a pan-European organisation, education entrepreneurships and a media outlet. The main ideas on which the proposal relies are coordinated, multi-city and international series events under a single, recognisable brand, with similar (familiar) formats but with fresh (and well communicated) content, led by central multidisciplinary themes in 2018 (European Year of Cultural Heritage) and sport (European Capital of Sport Sofia), and culture (European Capital of Culture Plovdiv 2019). Building on the Consortium’s existing understanding, developed through previous local initiatives including Researchers Night, and addressing findings of research (Special Eurobarometer 401, the MASIS report , the in-depth Education and Training Monitor 2017 for Bulgaria , the recently published Communication on Strengthening the European Identity through Education and Culture , REFRESH focusses on enhancing the public understanding of and engagement with science, encouraging children especially girls, to study STEM subjects. The participatory events will reach 3.6 mln, and engage 80,000 in least 14 cities/towns with live-streaming, face-to-face events at schools, libraries, museums, city venues and public transport, science talks and shows; hands-on experiments, lab visits and citizen science. The activities of the first year will allow learning to accrue from a thorough evaluation. The project will strengthen the capabilities of the partners in organising events for a general audience in open access format
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Adding Pieces to the Puzzle of Sexual Differentiation In P. falciparum: A Systematic Analysis of RNA Processing' (SPARk) targeting Horizon 2020.

assistant: **Abstract**

Malaria remains one of the most devastating diseases in modern times, with the heaviest mortality concentrated in young children living in resource-poor environments. Plasmodium falciparum causes the most severe form of malaria. The parasites have a complex life cycle, switching between a host and a mosquito vector. Transformation of a subset of parasites into specialized stages capable of sexual development – the gametocytes – is one of the most astonishing, yet not well understood, Plasmodium life cycle phases. As preparatory work for this proposal during my time at Harvard School of Public Health, I identified pathways specifically upregulated at the onset of sexual differentiation, an important gap in our knowledge of gametocytogenesis. Among these, four genes involved in different aspects of post-transcriptional gene regulation were highly upregulated. Studying this aspect of gametocyte biology can add to our understanding of how Plasmodium parasites orchestrate complex genetics switches and modulate the cellular response to developmental signals.The aim of this proposal is to provide insight how these RNA-binding proteins contribute to sexual stage-specific gene expression. This project employs genetic approaches to investigate the role of these proteins during sexual development of P. falciparum. For that I will generate transgenic parasites and analyse the resulting phenotype in detail. Additionally, this study aims at characterisation the splicing activity of recombinantly produced proteins and to determine target RNAs in order to elucidate the underlying mechanism of RNA processing control. This proposal can contribute to improved health conditions in malaria-endemic countries through a better understanding of malaria transmission and new approaches to treat t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Vulnerability Search and Prevention through Holistic End-to-end Risk Evaluation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the so-called ‘age of information’, information and communication systems (ICT) are the backbone of our digitalised society. Especially from an industrial perspective, we entrust our most delicate details to these tools and, logically, we demand the highest level of integrity and availability to avoid any eventual data loss, unavailability or, maybe more important, misuse. However, cyberattacks in EU are costing businesses around €38 billion/ year.  How can we maximise our protection against these risks? Our company, Prosa Security, is developing V-SPHERE; a new solution for industrial cyber security that unveils and prevents vulnerabilities of any ICT system in a holistic way, i.e., covering all the development cycle and all company perspectives. Involving all the stakeholders in the security process, this unique approach has demonstrated to be 10 to 100 times more effective in detection than traditional methods, as well as to reduce by 3 the time allocated for quality and security assurance in SW development projects, resulting in saving from €45,000 to €300,000 per SW development project. The overall objectives of this project are: assessing the viability of V-SPHERE and building a solid business and operational plan (Phase 1); conducting the planned technical and commercial activities to prepare its commercialisation (Phase 2); and initiate the formal large scale commercialisation, seeking the promotion of V-SPHERE and the networking with financers (Phase 3). Our business opportunity is promising, with the European market of cybersecurity to reach €38.10 billion and the specific market of security testing solutions valued at €2.71 billion in 2022. The expected outcome of the project is estimated at €23.3 million by 2023, besides the creation of 27 job positions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-Mathematics for Imaging and Optimal Design Under Uncertainty' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of this interdisciplinary project is to develop new mathematical and statistical tools, probabilistic approaches, and inversion and optimal design methods to address emerging modalities in medical imaging, nondestructive testing, and environmental inverse problems. It merges the complementary expertise of the investigators in order to make a breakthrough  in the field ofmathematical imaging and optimal design by solving the most challenging problems posed by new imaging modalities. The PI and Co-PI are leading experts in their respective fields (appliedanalysis and probability) and their researches have very strong interdisciplinary nature.The goal of this project is to synergize asymptotic imaging, stochastic modelling, and analysis of both deterministic and stochastic wave propagation phenomena. We want to throw a bridge across the deterministic and stochastic aspects and tools of mathematical imaging. This requires a deep understanding of the different scales in the physical problem, an accurate modelling of the noise sources, and fine mathematical analysis of complex phenomena. The emphasis of this project will be put on deriving for each of the challenging imaging problems that we will consider, the best possible imaging functionals in the sense of stability and resolution. For optimal design problems, wewill evaluate the effect of uncertainties on the geometrical or physical parameters and design accurate optimal design methodologies.In this project, we will build an exceptional interdisciplinary research and an innovative approach to training in applied mathematics.  We will train a new generation of applied mathematicians who will master both the probabilistic and analytical tools to best meet the challenges of emerging technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrating the Multiple Meta-Analysis: a framework for evaluating and ranking multiple health care technologies' (IMMA).

assistant: **Concept**

Health care practitioners face daily questions and make choices regarding the effectiveness and quality of several health technologies (e.g. alternative interventions). On this regard they usually consider meta-analysis; the statistical synthesis of results from relevant experiments. The main drawback of the current state of the art is that meta-analysis focuses on comparing only two alternatives. However, clinicians and scientists need to know the relative ranking of a set of alternative options and not only whether option A is better than B. There is an urgent need to establish and disseminate a robust framework for selecting among many treatment options, possibly after taking into account environmental and genetic interactions. The goal of the proposed project is to provide this by establishing and disseminating a revolutionary evidence synthesis toolkit. Its main methodological vehicle is a flexible statistical framework using Bayesian techniques for multiple-treatments meta-analysis. This will enable the relative ranking of all alternative health care options, will allow comprehensive use of all available data, will improve precision and confidence in the conclusions and will answer methodological questions related to bias. Once established in clinical epidemiology, the tool will be extended to genetic epidemiology to account for multiple genetic markers, environmental factors and effects of treatments. Based on ongoing collaborations with teams undertaking applied health care research I plan to evaluate the new tool empirically in real-life health care problems such as ranking the pharmacological treatments for osteoarthritis, indicating the best treatments for multiple sclerosis and ranking the vaccines for influenza.