RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Framework for the evaluation of management strategies' under Fifth Framework.

assistant: **Concept**

The complex nature of fishery systems and the interaction between management, exploitation, environment and biology means that it is not always possible to foresee the response to a given management action. It is proposed to use a computer simulation framework that will allow the performance of management strategies based on current and improved biological knowledge and management procedures to be evaluated. New strategies will be proposed that consider the 4 elements: Definition of management targets; Assessment of stock relative to targets; Recovery plans to move targets; Stable management regimes.ObjectivesDevelop a simulation framework to evaluate management strategies that are consistent with the precautionary approach whilst maintaining the viability of the fishing industry. Thereby provide advice to managers on the response of fish stocks to exploitation and management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Transfer the real 3D world to interactive creative endeavours in apparel industry'.

assistant: **Objectives**

Whereas the manufacturing and distribution of apparel has advanced in past years with the application of new CAM and ITC technologies, the design process is still very traditional. Sketching ideas, creating story boards, draping, and developing technical drawings (also known as technical sketches) are just some of the tasks that are still being done either in the old-fashioned way or with the aid of digital tools, most of which are spinoff uses of technologies developed for other industries, and not adapted to the necessities of the creative apparel industry.At the same time, there are emerging technologies that could reduce the timing and the cost of the design process, such as 3D scanners and 3D sketching tools. New low cost 3D scanners have indeed appeared in the market, and could allow a real customization of the clothes design. Moreover, libraries of 3D realistic avatars adapted to the target population of a new clothing collection will be a great improvement for mass production. Theoretically, a designer could sketch the design over the avatar of a customer, or over a realistic avatar that represents a target population. Sketching designs over real 3D bodies allows the visualization of designs in real dimensions, improves communication between the creative team, and reduce misunderstandings in the following steps (e.g. pattern making, manufacturing, etc.). The realistic visualization of the designs has many advantages:1) Elimination of manual tasks.2) Improvement of the communication between designers and decision takers (the managers that approve the design for manufacturing). The realistic visualization reduces misunderstandings and failures.3) Better cost analysis.InKreate expects to improve the apparel design process using low cost 3D scanners and 3D sketching
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'QCD perspectives on hot and dense matter'.

assistant: **Concept**

The main scientific objective of the School is an in-depth discussion of experimental and theoretical aspects of the ultrarelativistic nuclear physics. With RHIC accelerator at Brookhaven National Laboratory, operating with nuclear beams having a CMS energy 200 GeV per pp collision, coming into operation, a wealth of new data is expected to be available in the summer of the year 2001. Also, few years from now, LHC accelerator at CERN will work with nuclear beams at still higher energies, 5.5 TeV for lead nuclei. Theoretically a lot of new and exciting phenomena are expected in such ultrarelativistic heavy ion collisions, most notably, the increasingly important role of the deconfined quark-gluon matter created at their early stage. A school such as this is needed due to the rapid increase of the community of young theorists and experimentalists in this field.This school is unique in that we include topics relevant to both high-energy nuclear collisions and high-energy electron-hadron physics. There is much overlap in both the theoretical and the experimental goals of these fields, but at present, only little overlap of people. The organizers feel strongly that progress in both of these areas will involve an interplay of disciplines. The atmosphere provided by Cargese is ideal for the type of interactions we wish to encourage. The intimate setting and relative isolation of the conference place should generate many interactions between lecturers and students. The diversity of nationalities of the students should work for future international collaboration between the young people.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00118-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tailored biodegradable magnesium implant materials' (MAGNIM) targeting Seventh Framework.

assistant: **Abstract**

Cost reduction and improvement of the quality of life is a major issue in health care. This challenge can be tackled by intelligent biomaterials and smart implants which are resorbed by the body upon remodelling of the tissue: What is possible for polymer materials should also be realized for biodegradable metallic materials. MagnIM will train 12 ESRs to contribute to this demanding aims by the development of new aluminium free Magnesium implant materials with tailored properties specific for a bone related application especially in children and for sport medicine. To reach this goal carefully selected materials and processing routes will be combined with comprehensive research to elucidate the correlation between microstructure and corrosion processes. This will be monitored in vitro and in vivo. The ultimate goal will be a prototype implant design which is based on the achievements of this network. To do this, the specific combination of the MagnIM research team is necessary. MagnIM brings together world leading scientists from various research fields: Material scientists and engineers who develop new alloys with tailored properties for biomedical applications and medical scientists and biologists researching on macro- and microscopically changes in bones and bone cells with in vitro and in vivo methods. MagnIM collectively covers basically all aspects, instrumental techniques and approaches necessary to tackle successfully the challenge to understand, and ultimately control, interactions at the material – bone interface. The full achievements of this research are gained because the consortium covers the full value chain from fundamental engineering research towards implant production including relevant industry partners and clinics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Understanding selective neuronal vulnerability in Alzheimer’s disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The aim of this action is to understand the mechanisms behind the susceptibility of enthorinal cortex II  (ECII) neurons to neurofibrillary tangle (NFT) formation in Alzheimer´s disease. To do so we will modulate the expression of the genes that according to NetWAS (Network-wide Association Study) are more directly involved in NFT formation in ECII neurons. Understanding why the pathological lesions that lead to neurodegeneration appear earlier in some specific neurons of the human brain is one of the major challenges in the neuroscience field.Prof. Greengard´s lab has generated a transgenic mouse that allows the immunoprecipitation of ribosome-bound mRNAs specifically from ECII neurons (ECII-bacTRAP mice). We will perform AAV stereotaxic injections in the enthorinal cortex of these mice followed by RNA-seq to determine how the modulation of our target genes affects ECII neurons expression profile. We will also explore whether our intervention can influence ECII neurons susceptibility to NFT in P301S AD mice. The results obtained in mice will be validated by immunofluorescence and in situ hybridization studies in human samples from control and AD patients at different Braak stages.Our results could add extremely relevant information on the mechanisms underlying AD pathogenesis and reveal these genes as new therapeutic targets for the disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Functionally scaled computing technology: From novel devices to non-von Neumann architectures and algorithms for a connected intelligent world'.

assistant: **Innovation**

The Fun-COMP project aims to develop a new wave of industry-relevant technologies that will extend the limits facing mainstream processing and storage approaches. We will do this by delivering innovative nanoelectronic and nanophotonic devices and systems that fuse together the core information processing tasks of computing and memory, that incorporate in hardware the ability to learn adapt and evolve, that are designed from the bottom-up to take advantage of the huge benefits, in terms of increases in speed/bandwidth and reduction in power consumption, promised by the emergence of Silicon photonic systems. We will develop basic information processing building blocks that draw inspiration from biological approaches, providing computing primitives that can mimic the essential features of brain-like synapses and neurons to deliver a new foundation for fast, low-power, functionally-scaled computing based around non-von Neumann approaches. We will combine such computing primitives into reconfigurable integrated processing networks that can implement in hardware novel, intelligent, self-learning and adaptive computational approaches - including spiking neural networks, computing-in-memory and autonomous reservoir computing – and that are capable of addressing complex real-world computational problems in fast, energy-efficient ways. We will address the application of our novel technologies to future computing imperatives, including the analysis and exploitation of ‘big data’ and the ubiquity of computing arising from the ‘Internet of Things’. To realise our goals we bring together a world-leading consortium of industrial and academic researchers whose current work in the development of future information processing and storage technologies defines the state-of-the-art.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated SOlution to enhance COLD chain and logistic tracking' under Horizon 2020.

assistant: **Concept**

ScenarioTransport & Logistic (T&L) sector has experienced a fast expansion in the last decade; the temperature controlled supply chain represents a high value added segment that is experiencing a continuous push for service quality. Regulators, all over the world, are constantly introducing more demanding recommendations (e.g.: the recent Good Distribution Practise - EU C343/01 2013 - for the pharmaceutical products). On the other hand, the high cost of monitoring tracking information and temperature data during transports, and the absence of structured ICT solutions to aggregate operative information efficiently, risk frustrating regulators effort.InnovationERPlan developed a comprehensive ICT solution able to collect and aggregate information from T&L operations, including track & trace and temperature data that allow the users to have a complete and updated status of deliveries, an historical records depot for regulation compliance, and a platform to distribute data to its stakeholders. Moreover, the solution provide logistic floor and mobile systems equipped with state of art RFID technology to minimize impact of data acquisition procedures on workforce efficiency.Target MarketTransport and logistic companies working with temperature controlled shipments (mainly Pharma & Food sectors) are all potential users of the solution as well as their stakeholders (Pharma / food producers, retailers, etc.) with a focus companies operating in last mile delivery scenario (mostly SMEs)Phase I Objectives- To define the investment and the effort that the company should undertake to penetrate efficiently the European market- To validate the ability of the solution to bring economical return to the company into a defined period in order to evaluate sustainability of the business plan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Resolving Climatic impacts on fish stocks'.

assistant: **Concept**

Climate change will impact fisheries resources and challenge managers to develop sustainable exploitation strategies. Knowledge on the impacts of climate on fisheries resources is still fragmentary. RECLAIM will summarize current knowledge, test process understanding, improve predictive capacity and formulate future research hypotheses by examining trophic processes, geographical distributions and essential habitat requirements for marine and shellfish in the NE-Atlantic. A conceptual framework will be developed to distinguish between processes acting on individual (physiology, behaviour), population (predation, competition) and ecosystem (physical habitat qualities, biological productivity, trophic coupling) levels. The framework structures a literature re view to detect gaps in knowledge and, where possible, distinguishes between climate and anthropogenic influences.A comparative analysis follows quantifying climate variability and changes in distribution and productivity of:(i) individual species,(ii) selected fish and shellfish communities, and(iii) ecosystem structure and functioning.Target species represent different commercially important resources, ecosystem components (pelagics, demersals), and play key trophic roles (wasp-waist, apex predators) within NE-Atlantic ecosystems. Changes in ecosystem structure and functioning will be analysed from fisheries and scientific survey data including planktonic, benthic and fish production and consumption in relation to climate forcing and fishing. Relevant spatial and temporal scales of climate change and variability will be explored using time series analyses, spatial statistics and coupled 3-D hydrodynamic ecosystem models. Using a variety of approaches, RECLAIM will both hindcast as well as forecast the effects of cli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Treating stroke with Affibody molecules targeting the inflammatory mediator HMGB1' in the context of a Seventh Framework call.

assistant: **Objectives**

The scope of the project is to generate a candidate drug targeting the inflammatory mediator High mobility group box 1 protein (HMGB1) to be used in treatment of stroke. The candidate drug will be validated in animal models, characterized and optimized for subsequent clinical development.Stroke remains a leading cause of death and disability throughout the world. Within EU, more than 500 000 persons die of stroke each year. Of those surviving stroke, 50% are left with physical or cognitive impairment and the total annual cost of stroke is estimated at Euro 27 billion.Stroke occurs as a consequence of hemorrhagic insult or artery occlusion due to underlying cardiovascular disease. Pivotal in beneficial treatment of stroke is instant intervention. Blood clot dissolution using recombinant tissue plasminogen activator is the only pharmacological treatment demonstrated to limit neurological damage in stroke, but is only effective for patients who present within 3 hours after stroke onset. Thus there is an unmet need for an efficacious therapy that can be administered within and beyond 3 hours to achieve neuroprotection. HMGB1, released during the cerebral ischemic event and the subsequent neuroinflammation, is a well-characterized mediator of inflammation. Beneficial effects of blocking HMGB1 is proven in preclinical stroke studies. The drug to be developed is an Affibody molecule binding to and neutralizing HMGB1. Affibody molecules are engineered proteins significantly smaller than antibodies and therefore having favorable biodistribution properties, and a history of being efficient and non-toxic in clinical trials. In this application, we describe a multidisciplinary research consortium with Europe´s leading scientists in HMGB1 research and in registry-based clinical tria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Red-Shifted Fluorescence Protein Tomography' (RED-FPT).

assistant: **Innovation**

The introduction of transgenes that express fluorescent proteins (FPs) into cells has revolutionized the ability to visualize many cellular and sub-cellular processes that are otherwise invisible with traditional means of optical imaging. Fluorescent proteins have been widely used in microscopic imaging, however deep tissue imaging has not been possible, before the recent development of fluorescent proteins emitting beyond the 600 nm absorption threshold.  In the present proposal the applicant will study and develop a novel optical tomographic method for preclinical research applications with the use of the recently evolved red-shifted fluorescent proteins. The development is going to be based on modifying the existing Fluorescence Molecular Tomography method both in its experimental and theoretical part as necessary. The result will be a tomographic method and system that will be used to reconstruct in 3D the location of the fluorescent proteins deep inside the tissue of small animals (mice) with submillimeter resolution. The proposed method/system will be tested against various of the parameters of its operation and will be used to demonstrate its use in in-vivo biomedical imaging applications. A method/system like the proposed has the potential to become a high capability non invasive monitoring and diagnostic tool in bio-medical research on small animals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Translating Science into Policy: A Multisectoral Approach to Adaptation and Mitigation of Adverse Effects of Vector-Borne Diseases, Environmental Pollution and Climate Change on Planetary Health' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

PLANET4Health provides new knowledge and tools on environment degradation and its impact on human animal and ecosystems health. The project results will support policy making process and citizens awareness on sustainable planetary health, climate and environmental policies and adaptation and mitigation strategies to natural hazards. PLANET4health will develop collaborations from a large variety of organizations from the: environmental and climate science, public health, epidemiology, veterinary medicine, social, political and economic science, engineering, law and ethics, and communication, to produce solid knowledge and tools to facilitate learning and practice on the interaction between the natural system and human health. Four tailor-made case studies will be performed: 1) One Health effects of vector-borne diseases, 2) air pollution, 3) food contamination arising from soil and water contamination, 4) mental wellbeing linked to environmental and climate stressors, in different geographical area thanks to the large project network, that will draw universal conclusions and replicable solutions to improve the predictive capability and preparedness. The consortium will produce research, technological innovation, tailored outreach and training, and policy solutions through a cross-sectorial multidisciplinary scientific collaboration in line with the transnational character of planetary health. For these aims the project will: a) collect, organize and assure open availability of new and already existing data on climate and environmental indicators linked to One Health; b) carry out analyses on data and build innovative, inter-operable and multifunctional digital  prototypes; c) produce new knowledge and tools to support One Health policies by applying social science theori