RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'MHC-I biogenesis and degradation at the endoplasmic reticulum membrane'.

assistant: **Objectives**

One third of the cell proteome utilizes the secretory pathway for entrance into the endoplasmic reticulum (ER). However, the insertion of nascent proteins into or their translocation across the ER membrane, their maturation and assembly to oligomeric complexes and their degradation are very basic cellular processes of which we largely lack an integrative structural insight.I propose to use Cryo Electron Tomography (CET) to unravel the molecular mechanism of the biogenesis and degradation of Major Histocompatibility Complex-I (MHC-I) as a model substrate in situ. MHC-I are critical for immune responses to viruses and tumors. They are hetero-trimeric complexes formed by a light chain, a heavy chain and a variable cellular or microbial peptide. MHC-I folding is assisted by the chaperones ERp57 and calnexin at the ER membrane, where it assembles co-translationally, stabilized by tapasin. Once loaded with a peptide, MHC-I is exported to the cell surface for recognition by CD8+ T-cells. However, some viral immunoevasins like the human cytomegalovirus (HCMV) proteins US2 and US11 trigger the ER-Associated Degradation (ERAD) of MHC-I. I will combine data from CET, cross linking mass spectrometry (XL-MS) and in vitro functional assays on eukaryotic cellular and microsomal cell-free systems to provide an integrated picture of the complexes transiently involved in these processes.This work will make great contributions to our molecular understanding of cellular proteostasis and possibly provide novel molecular targets addressing diseases associated with ER stress.The proposed project will extend my knowledge from protein X-ray crystallography to the study of more complex molecular assemblies in association with membranes at larger length scales – ultimately the cell. Taken togethe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Concerted action on environment technology'.

assistant: **Objectives**

CENTEC is a proposal for a Concerted action on ENvironment TEChnology. The aim is to treat the following issues on a common European basis: *) Tools to compare environmental technologies to guide respective research and facilitate applications. *) Appropriate environmental technologies for non-industrialized countries *) Identification of necessary R&D contributions to the concept of Best Available Technologies *) Conversion of conventional prevention techniques into integrated environmental technologies *) Waste stream technologies These topics result from the priorities of problems identified during the workshops of EU funded projects in Vienna, Hanover and Copenhagen.They will be treated on the basis of 5 Working Groups to bring together research, legislation and industry to assure appropriate coordination, multidisciplinarity and best use of funds. This will also help to avoid duplication of work, attract new partners for projects and the solution of problems. The Working Groups will elaborate the specified task list of the topics above with the emphasis to integrate national programmes and other European efforts, projects and programmes. To assure a continuous and efficient contact within the Working Groups and to allow all interested persons from research, industry and involved organisations to take part in the exchange of information and to assure a broad use of informations gathered, the work will be done primarily on the basis of e-mail and net-groups. Widely disseminated information about the concerted action and the general possible access will ensure a multidisciplinary approach to the themes of the Working Groups. The results of the Working Groups will be presented and discussed in workshops to be used in research, legislation and industry with the followin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards greener and more sustainable analytical approaches: Development of an integrative supercritical CO2-based multidimensional system for bioactive compound study in natural and biological samples' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Chemical characterization is essential to the study of bioactive compounds in natural and biological samples but conventional preparative and analytical techniques are usually time, energy and solvent-intensive, posing environmental and health risks. Supercritical carbon dioxide (CO2) present an eco-friendly alternative due to its interesting physio-chemical properties. Prof. West’s research group has been developing approaches involving supercritical CO2 for two decades, and recently developed an integrated system combining supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) for the on-line extraction and analysis of polar and non-polar bioactive compounds from plants. Although feasible, such coupling is very challenging, especially when targeting compounds with a wide range of polarities. The next step is thus to further improve the developed system and explore its applicability to other samples with different matrices and classes of compounds. Specifically, the use of unified chromatography (UC), an advanced version of SFC, will be investigated to further expand the efficiency and potential scope of the system. Since the interfacing of the two techniques is a major bottleneck preventing the system from reaching its full potential, finding innovative solutions to facilitate the extract transfer from the first to the second dimension is necessary. An important part of this project will thus be devoted to investigating new interface modalities to address the compatibility problems and instrumental issues pertaining to this hyphenation. To boost chromatographic separation power and facilitate structural elucidation, the potential of incorporating multidimensional (mD) separation steps while coupling the system with mass spectrometry (MS) wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modification of Resin', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of the proposal is to modify several epoxy resin systems designed for the manufacture of fiber reinforced composites. These modifications include the use of silica nanoparticles, toughneres like core shell elastomers and combinations thereof. The modified resin systems are adapted to the processing conditions in the manufacture of the FRCs. The modifications are selected to increse significantly the performance of the FRCs by means of toughness, stiffness, fatigue etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Network for the exchange of methodologies and expertise on sustainable water management and land husbandry in the Mediterranean' (SOWAMED) under Sixth Framework.

assistant: **Objectives**

The global objective of SOWAMED proposal is to establish a methodology exchange network and build an expertise capacity between partners in several research projects (STREP and/or CA) of the INCO-MED Program under the 4th, 5th, and 6th PCRD in the domain of sustainable land and water resource management and the prevention of risks on cultivated and inhabited watersheds.The first step will be to identify and analyse, data, models and DSS available for soil and water management in the semi arid Mediterranean areas. It will base on the results produced by the INCO MED projects during the ten last years. The second step will be to test and discuss the availability of data, models or DSS set for particular conditions.The definition of their areas of competence and limits will help to make available to all users the range of methods and available tools for proposing solutions to questions of sustainable water management and land husbandry. The third step consists in reinforcing capacities of expertise and dissemination of data and methods.These objectives will be achieved through regional workshops focusing on three specific issues the management of cultivated watersheds in mountains and hills (water conservation management and land husbandry) the management of traditional irrigated perimeters (small and medium hydraulic works SMH) and intensive irrigation systems and the management of water and land uses especially in peri-urban agricultural perimeters (competition for land and the use of non-conventional water resources). The project will associate 3 EU and 5 MPC partners for duration of 24 months.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'BRINGING SURGERY TO THE 21ST CENTURY: REAL-TIME TISSUE ANALYSIS DURING CANCER SURGERY. Improving Patient Safety, Quality and Cost-Effectiveness'.

assistant: **Concept**

Currently, cancer tumor removal operation is based on preoperative imaging and postoperative pathological examination. There is a strong global trend towards more tissue-sparing and minimally invasive surgery. If all cancer is not removed in the operation, a reoperation is needed, leading to additional costs, impaired cost-effectiveness and impaired quality of life of the patient. The rate of incomplete removal of a tumor ranges from 10-60%.The breakthrough innovative Olfactomics device allows the surgeon to analyze the operated tissue in real-time during cancer surgery leading to optimal tissue removal without compromising the workflow of the operation and facilitating the use of existing instrumentation. The solution is based on noninvasive, real-time analysis of surgical smoke. The reduced reoperation rate results in significant benefits for the patient, surgeon, hospital and society.The market potential is high. Easily reachable market for the breast cancer surgery is 850M€ and market for other applicable specialties (such as prostate cancer, skin cancer, and intestinal surgery) is over 2,000M€.Olfactomics Oy is a Finnish university-based spinoff company founded in 2015 to commercialize the results of over 10 years of clinical and technical research. The team consists of 13 specialists in surgery, medical technology, software, data analysis, financials and law. The team has excellent connections in the international healthcare industry and sensor technology industry.The technology is currently at TRL 7. The first commercial product for research use will be launched in 2019. This project will focus on scale-up to Olfactomics medical device on breast cancer surgery. The impacts by 2027 include: +3,000 Olfactomics devices sold; +300,000 Olfactomics breast cancer surger
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Homeostasis and rupture of the gut epithelium in the presence of commensals and pathogens' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The molecular cross talks occuring at the interface between the intestinal epithelium and bacterial flora will be studied at two levels : (i) how commensals and pathogens affect innate immune signalling, thereby leading to tolerance of the resident microbiota, and inflammatory rejection of the pathogens. The theme of commensals and pathogens regulating this innate response, particularly how they respectively strengthen or weaken the network of humoral and cellular epithelial defense systems will be central here. (ii) How, in molecular and cellular terms, bacteria affect epithelial renewal. The gut of a germ-free mouse and of a conventional mouse show dramatic differences marked by global immaturity and slow epithelial renewal in absence of flora. In front of pathogens, the actual role plaid in the disease in altering the kinetics of  epthelial repair is unknown. The aim of this project is to study how commensals and pathogens affect intestinal epithelial renewal, particularly the key steps of the whole developmental process such as lineages decisions, entry in cycle and proliferation, migration and final differentiation, decision to engage in cell death. In order to address these fundamental questions, we will study a commensal microorganism : Lactobacillus casei, and a pathogenic  microorganism : Shigella flexneri as model organism, and will develop several novel systems such as reverse genetics of Lactobacilli, development of intestinal crypt models in vitro to study bacterial interactions, and development of a mouse model showing susceptibility to  human-specific enteroinvasive pathogens. This project aims at interfacing microbiology, cell biology, and development biology around the concept of microbes manipulating intestinal epithelial homeostaesis. It also includes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced Methodology for European Laeken Indicators' (AMELI) targeting Seventh Framework.

assistant: **Abstract**

The goal to turn the EU into the most competitive and dynamic economy by 2010 demands a full benchmarking system to monitor policy performance and their impact on progress. For this reason, the European Commission has engaged in selecting, collecting and analysing a set of indicators that are published each year. The Stockholm European Council has further emphasised the need for effective, timely and reliable statistics and indicators. A main challenge is to develop indicators for the main characteristics and key drivers. An utmost important and challenging area to be measured is social cohesion.  Based on a clear definition of social cohesion, a universally-accepted high-quality and robust statistics to adequately measure social cohesion is required. Further, tools for measuring temporal developments and regional breakdowns to sub-populations of relevance will be of great importance. In order to measure social cohesion with Laeken indicators adequately while regarding national characteristics and practical peculiarities from the newly created EU-SILC, an improved methodology will be elaborated within AMELI. This will ensure that future political decision in the area of quality of life can be based on more adequate and high-quality data and a proper understanding of the Laeken indicators by the users. The study will include research on data quality including its measurement, treatment of outliers and nonresponse, small area estimation and the measurement of development over time. A large simulation study based on EU-SILC data will allow a simultaneous elaboration of the methodology focusing on practical issues aiming at support for policy. Due to the fact that the Laeken indicators are based on a highly sophisticated methodology the project’s outcome may also serve as a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Assessment of the black sea sedimentary system since the last glacial extreme' to be submitted under Fifth Framework.

assistant: **Abstract**

ASSEMBLAGE is an integrated pan-European study of the northwestern Black Sea sedimentary system from the continental shelf to the deep sea. The Black Sea is a unique feature characterised by the only particularly wide shelf in the northwestern sector. It is the drainage basin of some major European rivers and is characterised by high sedimentation rates presenting favourable conditions for paleoclimatic studies. The project will increase the knowledge of the Southern European Ocean Margin and facilitate access to and use of the Black Sea seafloor and exploitation and exploration of its resources, and preservation of its environment. This will be achieved through the examination of existing and forthcoming geomorphologic, geophysical, stratigraphic, sedimentological data and will permit progress in deciphering the past climatic and environmental changes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'RESEARCH ON EFFICIENT INTEGRATED SYSTEMS FOR THE MANUFACTURING OF COMPLEX PARTS BASED ON UNIDIRECTIONAL TAPES FOR THE AUTOMOTIVE AND AERONAUTICAL' (FORTAPE).

assistant: **Concept**

More and more industrial sectors are demanding high performance composite materials to face new challenges demanded by the transport sector. Carbon and glass fibre unidirectional continuous tape reinforced composites are one of the most promising options. It would be reasonable to expect that the manufacturing methods to obtain composite parts made of this hybrid material will be capable to tailor-made and optimize even more the advantageous properties given by the tapes nature. However, at the moment, these technologies are not mature enough for a full industrial implementation. Main existing barriers are related to the high consumption of resources, lower rates of automation, high production of defective and the subsequent growth of the manufacturing costs. FORTAPE aims to solve these drawbacks through the development of an efficient and optimized integrated system for the manufacturing of complex parts based on unidirectional fibre tapes for its application in the automotive and aeronautical industry, with the minimum use of materials and energy.To achieve this objective, three main routes for fibre impregnation will be researched to manufacture the unidirectional carbon and glass fibre tapes: novel heating up technologies, melted supercritical fluid-aided thermoplastic polymers and fluidized bed of powders. Novel combination of process-machine approaches will be applied in overmoulding and in-situ consolidation to manufacture the composite parts for the targeted sectors. Novel mathematical modelling and computational simulation concepts will be developed to support the structural optimization and the failure prevention and new instrumentation strategies for process control will be implemented for the selection of the best process. The FORTAPE consortium, led by CTAG
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Hau of Finance: Impact Investing and the Globalization of Social and Environmental Sustainability' to be submitted under Horizon 2020.

assistant: **Abstract**

Impact investing is a major emerging phenomenon in global finance that promises to reconcile capitalism with sustainability. It is increasingly embraced by governments, civil society and the private sector in the Global North and South to solve social and environmental problems. The combined crises of climate change, inequality and mass migration in a context of economic austerity have spurred cross-sectoral impact investing partnerships in areas such as green infrastructure, women’s entrepreneurship, agroecology, refugee support and disease prevention. This burgeoning $200bn market promises flexible, holistic and profitable paths to sustainability, attracting major philanthropic organisations and institutional investors boasting fresh ethical and responsible mandates. Is impact investing merely a new frontier for capitalism, or does it represent a revolutionary chapter in global history? Will it benefit communities better than conventional development programmes? The time to answer these questions is now, as impact investing is still in its infancy and the first green and social stock exchanges are opening around the world. IMPACT HAU is an innovative, critical and comparative anthropological study of the moral and political dimensions of impact investing. Inspired by Marcel Mauss’s classic use of the Maori concept of hau, the ‘spirit of the gift’, it focuses on the designers, traders and beneficiaries of impact bonds to produce an empirically driven analysis of the multiple moral orders within contemporary capitalism. Six ethnographic case studies will provide grounded, detailed accounts of the design and implementation of impact investing in Africa, Asia, Europe and the Americas. These will support a critical appraisal of the current consensus among global policymake