RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Revolutionary silk-based bioink for 3D printing of ex vivo bone marrow models to advance drug development and personalized medicine'.

assistant: **Innovation**

Aim: The SILKink project aims to develop a breakthrough biocompatible hydrogel, i.e., a bioink, to 3D print  bone marrow tissue models that can be used for robust culture of human stem cells. The use of silk as the basis for novel bioinks (SILKink) helps to recreate tailored bone marrow-like microenvironments that will enable new applications in drug development and personalized medicine for bone marrow diseases. Here, we aim to optimize and validate SILKink, further define the business opportunity, and found an investment-ready spin-off company to commercialize SILKink.Unmet need: Bone marrow stem cells are fragile and require highly specific surroundings to survive and differentiate, therefore the presence of a soft tissue environment mimicking the human bone marrow is critical for reproducible culturing of these cells. There is a large unmet need for reproducible solutions that mimic the soft tissue of the bone marrow to allow advancements in drug development and personalized medicine approaches for bone marrow diseases.Solution: We will develop SILKink: a revolutionary bioink that is uniquely based on silk to closely mimic the 3D soft tissue environment of the bone marrow. SILKink will provide a matrix that supports all bone marrow cells including hematopoietic stem and progenitor cells and allows to 3D print ex vivo bone marrow stem cell models in the shape or volume desired.Consortium: University of Pavia (UNIPV) and partner CELLINK have developed the SILKink prototype during FET Open project SilkFUSION and co-own the background IP. Partner Catalyze-Group – Venture Building Team (CAT) will bring commercial expertise to develop an optimal market access strategy for SILKink. UNIPV will be responsible for SILKink optimization, manufacturing, and validation. CELLINK w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improved Software development for Failsafe Embedded applications' (SAFE) under Fifth Framework.

assistant: **Objectives**

The SAFE project is targeted at the improvement of software development processes for failsafe software applications. A best practice project will be performed to show the benefits of introducing a system based CAD tool that enables component based embedded software generation for control systems of Automatic Guided Vehicles (Ages).High development costs and short time-to-market requirement urge companies to seek for an improved software development process. Moreover, there is increasing demand for more complex and fast AGVs with strict requirements on safety and reliability of the control system. Such control systems should not be built manually, since no fail-safe applications can be guaranteed. The process of software development is becoming increasingly complex and strongly determines time to market as well as reliability and safety of the AGVs.Frog Navigation Systems B.V (FROG). is a Dutch SME developer of control systems for Automatic Guided Vehicles. Currently FROG builds AGVs for internal transportation within factories or for public transportation purposes (e.g. unmanned vehicles at airports) FROG will perform a Best Practice Pilot on a baseline software development process. This pilot will prove that introducing component based development of methodologies and tools for the (semi-automatic) generation of embedded control software will contribute to:. More efficient and cheaper software development process;.Faster software development;.Reducing time to market for new products;.Higher quality, deadlock and bug-free software;.More reliable and safer end products (AGVs).The Best Practice Pilot will be supported by Institute National de Recherche en Informatique en Automatique (INRIA, tool developer) and Robosoft, a French SME targeting at the further exploitation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FORUM FOR ALLERGY PREVENTION' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The prevalence of asthma and allergies across Europe is very high. The associated societal burden of costs for the treatment and management of these conditions is enormous. Current therapies are effective in controlling symptoms in most patients, but no curative or preventive approach has been found. The overall aim of the FORALLVENT project is the creation of a platform and forum for the development of strategies enabling to close the gap between the science on allergic disease and the practical application of its results in prevention, clinical treatment and in the formulation of specialized foods. Future research in the most promising avenues for the development of innovative preventive strategies to combat the allergy epidemic of the 20th century shall be prepared. This aim will be achieved by first exploiting and synthesising knowledge from different disciplines involved in and from experience gained in various previous experimental and epidemiological studies conducted within the 5th and 6th framework programme and other research in Europe. The FORALLVENT project will then enable an interdisciplinary expert group to brainstorm on the most promising innovative strategies for the development of novel preventive and therapeutic approaches involving science and industry. A further element will be the maintenance of an existing birth cohort to prospectively evaluate the potential of allergy protective substances by testing generated hypotheses in vivo. An overall important component is the dissemination of findings to potential partners in industry, trade associations, interest groups, patient organisations, the general public and policy making bodies by means of target-oriented publications, fact sheets and a website. The FORALLVENT study will therefore also serve as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Lab-to-tech transition of the current best low temperature electrolyser technology for CO2 reduction to CO using solar energy' (SolarCO2Value), addressing dissemination and exploitation.

assistant: **Impact**

One of the most important challenges of humanity is to maintain economic growth and wellbeing in an environmentally sustainable way. The European Green Deal addresses this issue and it aims at making Europe climate neutral by 2050. To reach this aim, a high priority opportunity is the utilisation of waste carbon dioxide to produce valuable chemicals (e.g. energy carriers, fine chemicals, pharmaceuticals) in an environmentally and economically sustainable manner. In our previous ERC Proof of concept project, we have demonstrated that the most viable approach where sunlight is first converted to electricity by a solar photovoltaic (PV) cell and CO2 is then reduced electrochemically to carbon monoxide, which can be further processed to valuable chemicals. The technoeconomic analysis performed during the ERC PoC project confirmed the competitiveness of this solar energy conversion approach. Our team developed the current best performing low temperature CO2 electrolyser cell at laboratory scale, published the results in Nature Energy and filed two PCT patent applications regarding this technology. The aim of this project is to translate our scientific and technological excellence to a commercially appealing value proposition. Our objective is to develop, build and operate a containerised demonstrator scale CO2 electrolyser unit (capable of processing 100 t CO2/year) as well as to validate its performance using photovoltaic power. We aim to perform a detailed technoeconomic assessment and develop a business plan to attract investors in order to scale the technology further and start its commercialization. By the end of the project, we aim to become ready for Series A investment and/or EIC-Accelerator blended finance. The success of this project will represent a genuine breakt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Evolution of Early Symbolic Behavior' under Horizon Europe.

assistant: **Concept**

Understanding the unique evolutionary trajectory taken by the human species is impossible without appreciation of our special capacities for symbolic cognition and behavior. But how did these capacities evolve during the late Middle Palaeolithic? Within only the last couple of decades, early milestones in human symbolic behavior have been continuously revised as new excavations across the globe challenge previous long-held assumption. However, at the same time we have made little progress in our understanding of past symbolic behaviour and the mechanisms by which it evolved. As tools of the mind, symbols are constituted by the intangible cognitive processes they evoke in pragmatic use contexts, which are inaccessible to the standard methods of archaeology or genetics. With eSYMb, I will establish a novel integrative framework for the systematic investigation of early symbolic evolution directly frontloading records from archaeology in experimental investigations and computational modelling based on state-of-the-art methods from the cognitive sciences.  Starting from the assumption that symbolic artefacts evolve adaptively over time to better fulfil their intended functions, I will investigate these structural changes and their cognitive implications to inform inferences about their past use. The framework will thus establish transparent, data-driven methods and criteria to test – for the first time - concrete hypotheses about early human symbolic behaviour from 6+ archaeological sites from the late Middle and early Upper Palaeolithic (~150.000 – 12.000 years ago) based on measures critical to symbolic cognition and behaviour. In summary, the objective of eSYMb is to bring systematic scientific rigour to the investigation and interpretation of early human symbolic behavi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Quantitative pathway analysis of natural variation in complex disease signaling in C. elegans'.

assistant: **Objectives**

Complex human diseases account for 60% of the deaths in Europe. The genetic variation – that is the genetic make-up of all alleles at all loci - of complex disease pathways determines individual disease susceptibility and treatment prospects. Because humans are genetically diverse the EC prioritizes research which leads to a better understanding of the natural variation in genetic pathways underlying complex diseases. But for ethical reasons there is insufficient statistical power to identify these genetic mechanisms in large human populations. Therefore the extent and importance of natural variation in disease signaling pathways of complex human diseases remains largely unknown.   PANACEA will investigate the influence of natural variation in genetic pathways in the worm Caenorhabditis elegans. C. elegans is an important model for the identification and characterization of genes associated with cancer in humans. Therefore PANACEA focuses on cancer signaling pathways as a prototypical example of a complex disease. The project will address two pivotal quations: i) how natural genetic variation affects complex disease signaling pathways, and ii) whether we can predict the effect of the natural genetic variation on these pathways. We will collect, store and analyse high-throughput genomic and proteomic data in genetically highly diverse populations. In conjunction with cellular developmental data we will construct a systems biology model aiming to describe and understand the effect of natural variation on cancer signaling pathways.   The outcomes will provide i) an extensive data base of novel candidate genes and their genetic variation, and ii) a comprehensive systems biology analysis of how this genetic variation affects cancer development. PANACEA advances the FP6 proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Process innovation for environmental friendly dry-cleaning technology with co2' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Adequate but not optimised cleaning of soiled garments as quantified by monitors using dp CO(2) as compared to conventional cleaning with perchloroethylene.The Project will investigate the use of CO(2) (carbon dioxide) under sub or supe rcritical dry cleaning (SCDC) conditions as an alternative to perc and CFC 113 for 4 major market segments of the dry cleaning industry, namely textile cleani ng of consumers garments, garments from institutions with many water soluble so ils, workwear which is very heavy soiled with oils and pigments in general and cleaning of leather and suede garments. Different cleaning processes with speci al types of detergents for the different segments have to deal with different t ypes of soils, different types of textiles and leathers/suedes as well as with different criteria for cleaning effect and appearance of the garments. Solv ed problems: The dry cleaning industry uses perchloroethylene (perc) or CFC 1 13 as cleaning solvents. As perc has risks to human health and shows toxic effe cts, far more legislative restrictions for the use of this solvent has been set in the near future, which restrictions for perc likely cannot be met by indust ry. CFC 113 contributes to the destruction of the ozone layer and is being phas ed out already. CO(2) is non flammable, non toxic and a renewable resource under sub or supercritical dry cleaning (SCDC) conditions. The development of the us e of SCDC with CO(2) for the cleaning of all 4 major market segments is the focus of this research & development project. The proposed Project for SCDC with CO(2) deals with a cleaner technology, with reduced emissions of harmful substances, with a build in CO2 recycling ability, without generating hazardous waste and with reduction of the use of scarce natural resources
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High-throughput dissection of the genetics underlying complex traits' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The vast majority of genetic diseases are complex traits, conditioned by multiple genetic and environmental factors. Yet our understanding of the genetics underlying such traits in humans remains extremely limited, due largely to the statistical complexity of inferring the effects of  allelic variants in a genetically diverse population. Novel tools for the dissection of the genetic architecture of complex traits, therefore, can be most effectively developed in model organisms, where the contribution of individual alleles can be quantitatively determined in controlled genetic backgrounds. We have previously established the yeast Saccharomyces cerevisiae as a model for complex traits by unravelling complex genetic architectures that govern quantitative phenotypes in this organism. We achieved this by pioneering approaches that have revealed crucial information about the complexity of the underlying genetics. Here we propose to advance to the next level of complex trait dissection by developing systematic, genome-wide technologies that aim to identify all of the variants underlying a complex trait in a single step. In particular, we will investigate traits involved in mitochondrial function, which are both clinically relevant and highly conserved in yeast. Our combination of genomic technologies will allow us to: 1) systematically detect, with maximal sensitivity, the majority of genetic variants (coding and non-coding) that condition these traits; 2) quantify the contributions of these variants and their interactions; and 3) evaluate the strengths and limitations of current methods for dissecting complex traits. Taken together, our research will yield fundamental insights into the genetic complexity of multifactorial traits, providing valuable lessons and establishing no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Network of Excellence on Engineering Secure Future Internet Software Services and Systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The Network of Excellence on Engineering Secure Future Internet Software Services and Systems (NESSoS) aims at constituting and integrating a long lasting research community on engineering secure software-based services and systems.<br/>The NESSoS engineering of secure software services is based on the principle of addressing security concerns from the very beginning in system analysis and design, thus contributing to reduce the amount of system and service vulnerabilities and enabling the systematic treatment of security needs through the engineering process. In light of the unique security requirements the Future Internet will expose, new results will be achieved by means of an integrated research, as to improve the necessary assurance level and to address risk and cost during the software development cycle in order to prioritize and manage investments. NESSoS will integrate the research labs involved; NESSoS will re-address, integrate, harmonize and foster the research activities in the necessary areas, and will increase and spread the research excellence. NESSoS will also impact training and education activities in Europe to grow a new generation of skilled researchers and practitioners in the area. NESSoS will collaborate with industrial stakeholders to improve the industry best practices and support a rapid growth of software-based service systems in the Future Internet.<br/>The research excellence of NESSoS will contribute to increase the trustworthiness of the Future Internet by improving the overall security of software services and systems. This will support European competitiveness in this vital area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Blc_2003' under Fifth Framework.

assistant: **Concept**

Advanced training of young researchers is a most important factor for the future development of biomedical science. Based on regional links, collaboration and expertise in science and education the Medical Faculties of the Universities of Copenhagen, Kiel and Lund have established the Baltic Lab Course (BLC) to combine their efforts in training of young researchers. BLC_2003 will concentrate on highly relevant topics of neurobiology and neurology. Corresponding to the program of the BSS, one part of the courses addresses scientific approaches of neuronal dysfunction and death programs, combined with the corresponding pro-inflammatory and pro-degenerative activation of microglia; particular focus is on the signal-transduction-cascade of c-Jun N-terminal kinases (JNK), a central mediator of neuronal death. This schedule reflects the basic intraneuronal and extraneuronal processes underlying a variety of neurodegenerative disorders. The courses are on different levels part addressing both, neuroscientists and clinicians. These fields have dramatically expanded because of the rapid scientific development and the need to cope with chronic progressive diseases, which are an economic burden to Society.