RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Precise and efficient genetic improvement of cereal seeds' (SEEDDESIGN), addressing dissemination and exploitation.

assistant: **Impact**

Cereal seeds are agriculture's most important renewable resource for food and industrial raw material. Conventional methods for the improvement of quality and yield have produced spectacular advances in the past. Future developments will involve tapping the vast potential of the modern technology of plant modification. The chances of Successful modification increase if the activity of the transgenic can be precisely directed to the targeted cells. This requires the isolation and characterisation of many more cell type-specific promoters than are currently available. Seed Design aims to isolate at least two functional promoter sequences for each of the cereal seed compartments, thus allowing to efficiently modifying seed composition. This will be of enormous potential benefit for both European farmers and consumers by improving quality and diversity of products. In addition, this technology will allow the EU seed Industry to keep abreast of global competition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Refined screening for novel targets in the tumor vasculature' (RESTART) targeting Seventh Framework.

assistant: **Abstract**

Angiostatic compounds have made their way into the daily clinical management of cancer, but their impact on patient survival is rather limited. This is likely due to the fact that most current drugs are antagonists of tumor produced growth factors, a strategy expected to induce drug resistance. A better strategy would be to target the tumor vasculature directly. Several markers of tumor endothelial cells have been described but most of them lack sufficient specificity.The applicant proposes to use Next Generation Sequencing (NGS) to identify the population of genes specifically expressed in primary prostate carcinoma and its metastases. Subsequently, this population of genes is screened for genes that are re-used during angiogenesis, and consequently overexpressed in the tumor endothelium. Prioritization of targets will be done by (i) level of (over)expression, (ii) membrane expression or secretion and (iii) existence of human ortho/homologs. After initial validation by qPCR in the source transcriptomes used for NGS, further validation of the targets will be done through loss- and gain-of-function assays. For 2-3 targets monoclonal antibodies will be generated. These antibodies will be tested in in vitro angiogenesis bioassays, and applicability will be preliminary tested in a preclinical mouse tumor model. Finally, the human ortho/homologs of the gene will be identified and validated for overexpression in human tumors.The novelty of the proposed work is the NGS approach for selection of tumor endothelial markers, through screening for high expression in the full tumor transcriptome and absence in healthy full body RNA.The prior experience of the applicant and the host laboratory will help the current project to succeed in reaching its goals.In our view, it is feasible
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Components for Highly Advanced time-Resolved fluorescence MIcroscopy based on Nonlinear Glass fibres' to be submitted under Seventh Framework.

assistant: **Abstract**

The project CHARMING aims at developing compact and fully fibred visible lasers for fluorescencespectroscopy, high resolution confocal microscopy and tryptophan imaging. These applications requirepulsed operation (about 100 ps at repetition rates from 1 to 80 MHz), various wavelengths in the visible(from 515 to 630 nm typically) and in the UV (for tryptophan imaging), high average power (up to 500 mW for high resolution) with a polarisation maintaining fibre delivery when possible.These wavelengths cannot, in most of the cases, be addressed directly. Therefore, in order to respond tothese applications with fibre based solutions different technological building blocks have to be developed.The project CHARMING will focus on the development of semiconductor laser sources in the 1.1 μm to1.2 μm band, Bismuth and Raman amplifiers, pulse gating and wavelength conversion fibre basedsolutions. This last function is certainly the more challenging in the project.Periodically Poled Singlemode Fibres (PPSF) for Second Harmonic Generation (SHG) have beenproven at laboratory scale but breakthrough approaches are required for this technology to be integrated in future systems. Various innovative approaches, in particular the use of Micro-structured Optical Fibres (MOF), will be investigated to convert this promising technology into potential products.SHG and other functions developed in CHARMING will be integrated in gain-switched and modelockedlasers at different wavelengths in the visible. The compatibility of these sources with the requirements of the imaging applications targeted in the project will be demonstrated.Finally, the performances of the devices will be pushed beyond these specifications (in the Watt level)for targeting a broader potential impact (like for instance, appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Exploring selected long non-coding RNAs as diagnostics and  therapeutic targets for heart failure'.

assistant: **Concept**

Despite clinical advances, diseases of the cardiovascular system are the most common cause of morbidity and mortality in the EU with currently 50 million people suffering from heart failure. These important challenges call for a better understanding of underlying mechanisms to enable development of innovative, effective diagnostic and therapeutic strategies for heart failure. Cardiac stress such as myocardial infarction or hypertension leads to cellular “remodeling” of the left ventricle resulting in heart failure. Protein-coding genes originate from only 1.5% of the genome, whereas the larger remaining portion is often transcribed to non-coding RNAs, of which functional importance is still ill understood. We pioneered a role of small microRNAs as diagnostics and therapeutic targets for heart failure (Nature, 2008; Nature Comm, 2012, J Clin Invest, 2014). We now will focus on the larger fraction of long non-coding RNAs (lncRNAs) and their functional roles, as well as diagnostic and therapeutic use in heart failure. The proposal has the following interconnected objectives: a) identify novel functional relevant cardiac remodeling-associated lncRNAs; b) characterise key lncRNA cardiac targetomes; c) investigate lncRNA-paracrine mechanisms and the diagnostic and prognostic potential of cardiac-derived extracellular lncRNAs using large clinical cohorts; and d) discover their therapeutic potential to prevent cardiac remodeling in clinically relevant animal models. Innovative molecular and cell-based methods, a unique lncRNA-shRNA library, genetic animal models and availability of large clinical biobanks will form the basis for a successful strategy. LONGHEART will lead to ground-breaking new insight into the role of lncRNAs in the heart. These findings will firmly establish l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel metal catalysts containing new dianionic spectator ligands' under Fourth Framework.

assistant: **Concept**

Research objectives and content The production of olefins is a giant industry. The first plant (Exxon, USA, 1991 ) using cyclopentadienyl-metal catalysts opened a new chapter in the plastics industry. Homogeneous catalysis, using cyclopentadienyl-based Ti or Zr complexes, is now important in polymer technology. Few alternatives to cyclopentadienyl ligand types have generated active catalysts. We shall build on recent work (Lappert, et al. ) on the synthesis of lithium compounds of the new dianionic ligands (1)2-, (2)2- and (3)2- (see 1.2); which will be used as novel spectator ligands in the context of titanium(IV), zirconium(IV), hafnium(IV) and lanthanide metal(III) chemistry to prepare and characterise novel complexes of types I-IV useful for (a)-olefin reactions. Training content (objective, benefit and expected impact) The objective is to gain new experience, both scientific and cultural. In addition to my current knowledge of main group chemistry as applied to materials, I wish to acquire skills in molecular synthetic chemistry and in the application of novel compounds as polymerisation catalysts. The proposal has considerable novelty and will lead to publications and possibly patents. Links with industry / industrial relevance (22) Prof. Lappert has good relations with several companies including, Borax Europe Ltd., Dow Corning Ltd. (UK), FMC Corporation (UK) and BASF (UK and FRG) where I expect to spend time evaluating my catalysts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A novel bio-controlling pre-harvest method to  eliminate the mycotoxins contamination in agri-food sector' (FREEMYCO).

assistant: **Concept**

Mycotoxins are toxic molecules produced by different fungal strains such as Aspergillus, Fusarium and Penicillium that mainly affect grains both in the pre and postharvest stages. One of them, aflatoxin, is one of the most hazardous toxins for human health, and till date there is no solution to control it through a sustainable way. Ideagro is a 9-year experienced company which main activity is R&D focused on the agrifood sector. Our R&D efforts have found that a Trichoderma koningiopsis strain fungus (IDE-Tri1) is able to control the aforenamed fungi and toxins in cereals crops in a preharvest stage. Thus, in the wake of these investigation works, FREEMYCO is born as the unique bio-fungicide active substance that have shown its absolute effectiveness for Aspergillus fungi and consequently aflatoxin in cereal crops during pre-harvest stage, for both conventional and organic agriculture. It will be able to control also remaining mycotoxins which are less harmful. controlling the mycotoxins, as it has been successfully tested through in vitro and in vivo tests. FREEMYCO is a great economic opportunity (cumulative profit of €11.47M in three years after its launching) to take advantages of a natural product for facing a serious problem for agriculture, food quality/security and human health in a sustainable way. Our target customers are the largest phytosanitary producers’ firms. We consider that through a B2B business approach we will be successful to penetrating into the highly competitive global bio-pesticide market and ensure our product selling. This Feasibility Study’s goal is to deepen in those key points to assess the economic, technical and commercial viability of FREEMYCO (including in vivo trial and end final product formulation) to tackle this challenge for us to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Identification of protein kinases and signalling pathways important for Plasmodium falciparum malaria transmission'.

assistant: **Innovation**

Malaria is a devastating disease caused by the apicomplexan parasite Plasmodium. Plasmodium falciparum represents the most severe and life-threatening form of human malaria, causing over 500,000 deaths per year. There is no efficient vaccine available and resistance to all currently used drugs reported. One of the major problems in eradicating human malaria is the transmission of the parasites sexual stages, the gametocytes. These are formed in the blood and develop through five different morphological stages in specific organs of the human host. When fully mature after 10-12 days, gametocytes are released into the blood stream to be transmitted by the mosquito. The molecular regulatory mechanisms important for the formation of gametocytes are poorly understood but there is evidence showing that phosphorylation of epigenetic regulators plays a key role. The kinases that mediate these phosphorylation events and the proteins within their signalling networks, however, are not known and their identification is the aim of this proposal. Specifically I will: 1) Develop a novel tool to enrich early stage gametocytes from parasite culture using cell-type specific surface biotinylation and affinity purification. Development of this novel technology will represent a significant enhancement in our ability to study early stage gametocytes, which are currently very hard to isolate from cell culture.2) Identify the signalling pathways that are used during the early stage of sexual development by near-system-wide quantitative phosphoproteome analysis comparing early stage gametocytes from Aim 1 with asexual parasite stages.3) In a complementary approach I will systematically test 10 kinase knockout lines available in the lab for their ability to form gametocytes and gametes. The funct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'RECEPTivity and amplitude-based transition prediction'.

assistant: **Innovation**

The RECEPT project will deliver upstream aerodynamics research that will contribute (i) to the drive to strengthen the competitiveness of European manufacturing industry, (ii) to the need to improve the environmental impact of aircraft with regards to emissions.Within the RECEPT project, knowledge about transition phenomena and theoretical/numerical tools obtained during the last 50 years since the eN method was proposed, are used to develop the next generation transition prediction methods. The new method will be an amplitude-based prediction method incorporating true effects of the disturbance environment of the incoming flow, the so called receptivity process, as well as knowledge about actual amplitudes at which disturbances breakdown to turbulence. This will largely remove the need for empirical correlations and render possible accurate prediction of the onset of transition both under wind tunnel and free-flight conditions.Proposed research activities within RECEPT project will also contribute to design of more advanced transition control devices. Consequently, it will contribute to achieving the objectives for technology readiness to reduce fuel consumption and hence emissions. It directly addresses the topic of AAT.2010.1.1.1, AAT.2010.4.1.1 and AAT.2010.4.2.1.The RECEPT consortium consists of 12 organisations from 4 different member states (Sweden, Italy, France Germany) and one of International Cooperation Partner Countries, Russia. It contains 3 aircraft manufacturers (Airbus, SAAB, Piaggio), 5 research organisations (CIRA, DLR, FOI, ITAM, ONERA) and 4 universities (Kungliga Teknika Högskolan, Università di Genova, Università di Salerno, Universität Stuttgart). Participation of industry will directly transfer the new knowledge and greatly improved method to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European Plate Observing System' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

To understand the complex Earth System requires an integrated observational strategy and infrastructure to record key diagnostic features of its dynamics. Accordingly, this infrastructure must include geographically distributed and multidisciplinary monitoring instruments and observations. The European Plate Observing System (EPOS) will meet this challenge. The proposed RI (EPOS) will create a single sustainable, permanent and distributed infrastructure, integrating land-based geophysical monitoring networks, local observatories (including permanent in-situ and volcano observatories) and experimental laboratories in Europe. EPOS will give open access to geophysical and geological data and modelling tools, enabling a step change in multidisciplinary scientific research into different fields, including seismic and volcanic hazards, environmental changes as well as energy and long-term sustainability. This will result in benefits to society.Presently, the different European countries own a mosaic of hundreds of impressive, but separated networks, observatories, temporary deployments, labs and modelling facilities, etc... for solid earth studies. Long-term sustainability of plate observations, optimising access to, and combining a wide variety of solid Earth data and modelling tools are prerequisites to innovative research for a better understanding of the physical processes controlling earthquakes, volcanic eruptions and other catastrophic events (landslides, tsunamis) together with those controlling Earth surface dynamics (crustal response to deformation and to global change). EPOS will enable the scientific community to study the same phenomena from a multidisciplinary point of view, at different temporal and spatial scales (from laboratory to field and plate tectonic sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reinforcing S&T Capacities of Two Emerging Research Centers for Natural and Industrial Pollutant Materials in Serbia and Slovenia' to be submitted under Seventh Framework.

assistant: **Abstract**

The project RESTCA-TERCE-NIPMSS is aimed at reinforcing the S&T potential of two emerging research centers, which are dealing with study of natural and industrial solid pollutants: (1) Mineralogy-Crystallography and Petrology-Geochemistry Departments of the Faculty of Mining and Geology, Serbia (UB-FMG) and Department of Geochemistry and Environmental Geology, Geological Survey of Slovenia (GeoZS) - by establishing strategic partnership among each other and with the Institute of Geosciences, Division of Mineralogy, University of Frankfurt, Germany (GUF). The major project objectives are: (i) strengthening the international co-operation networking and partnership between the UB-FMG, GUF and GeoZS and setting-up a brain-gain environment, (ii) improving material research standards at the UB-FMG by renewal and upgrade of the facilities, (iii) exploiting the RTD results of the GeoZS and UB-FMG and promoting them to national/regional centers of excellence, (iv) networking among the institutions from the European region of convergence and Western Balkan, (v) promoting the ideas of the EU 7th Framework Program, and (vi) counterbalancing the effects of ’brain drain’ in Serbia. These objectives are to be achieved within 36 months during which support and management actions organized in six Work Packages will be undertaken. These actions include (i) staff mobility in order to mobilize and reinforce the quality of human resources, (ii) purchase and renewal of the equipment, (iii) organization of lectures, short seminars and thematic workshops, (iv) opening two post-Doc positions, and (v) various dissemination and management activities.  The RESTCA-TERCE-NIPMSS goals are to generate real scientific progress in the targeted research centers in Serbia and Slovenia without creating str