RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Invasiveness and the microbiome: gut microbial community dynamics in an invasive-native vertebrate system'.

assistant: **Innovation**

Biological invasions are one of the major threats to biodiversity worldwide, due to the many impacts and rapid spread ofinvasive alien species (IAS). However, the exact mechanisms underlying invasiveness remain poorly understood. Ihypothesise that metagenomic plasticity may be involved in invasions, i.e. IAS may be able to quickly acclimate and adapt totheir new environment and oust native species thanks to the higher dynamism of their microbial community structure and/orgene expression patterns. I will study microbiome dynamics in two phylogenetically-close mammals: a successful invader(grey squirrel, Sciurus carolinensis) and a native species ousted by the former (red squirrel, Sciurus vulgaris), investigatingthe diverse interplay among their gut microbiome, parasite infection, dietary flexibility and behaviour (individual personality). Iwill employ an observational approach in a natural experimental setting, comparing variation in the microbiome-phenomedynamics of the two species at both the individual-level (across seasons) and population-level (along a natural-urbangradient). InvasOME will help disclose the mechanisms behind invasiveness and rapid adaptation of IAS, offering usefulinsights that may prove relevant for the prevention and management of biological invasions. This project is highlymultidisciplinary and perfectly integrates several disciplines part of my skill set (invasion ecology, parasitology andbehavioural ecology) with state-of-the-art metagenomics in which I will receive advanced training by the proposed host, whohas a relevant experience and an innovative and interdisciplinary approach to these fields. I designed this project also toenhance my transferable skills, making the most of the host institution initiatives. I am thus confident that InvasO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification of new colorectal cancer susceptibility genes' in the context of a Seventh Framework call.

assistant: **Objectives**

The overall aim of this proposed project is to discovery new colorectal cancer (CRC) susceptibility genes to better understand the colorectal carcinogenesis process and improve the molecular diagnosis the affected families.CRC is one of the most important causes of morbidity and mortality in occidental countries. An early diagnosis of CRC as well as clinical surveillance of those with an increased risk to develop a CRC leads to an important decrease of CRC morbidity and mortality. Genetic diagnosis is a powerful tool to detect at risk patients, and although some genes have been demonstrated to cause CRC, they explain only a small proportion of cases. On these bases, a better understanding of the genetic contribution to CRC is necessary to achieve a meaningful impact on the disease. Here we propose a trans-Atlantic collaborative project to find new CRC susceptibility genes.Our first aim will be to identify new highly penetrant CRC susceptibility genes and variants using an exome-wide approach. Recent studies have demonstrated the feasibility of whole-exome sequencing (WES) as a powerful discovery tool for germline mutations in other familial cancers. By accurately selecting the families to be studied we expect to increase the gene identification rate. To this aim, we will restrict our WES analysis to highly enriched familial cases from two populations with an already demonstrated founder character (Québec –Canada– and Catalonia –Spain–).Given the recent evidences of the involvement of two spindle-assembly checkpoint (SAC) genes (BUB1B and BUB1) to hereditary colorectal carcinogenesis, our second aim is to identify new moderately penetrant CRC susceptibility genes and/or variants that are involved in the SAC pathway. From previous evidences we hypothesise that diminished
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'eM-POWERing SME Clusters to help SMEs to overcome the valley of death' (MPowerBIO), addressing dissemination and exploitation.

assistant: **Impact**

The MPowerBIO project will obtain feedback from clusters, SMEs and investors on the concrete challenges they have regarding investments and build an online platform containing digital tools for evaluating investment readiness, as well as online training modules to build the capacity of clusters to train their SME members. The project will provide 10 training the trainers events for a total of 90 clusters across the bioeconomy, covering most of Europe, supported by the online platform. This will  the improve the capacity of participating clusters to service their SME members, and allow them to test the learning on SMEs in a supervised manner, at a series of 10 regional events, helping the SMEs to prepare and present high-quality projects to investors.  The best SME projects will be selected by investors, and invited to one of two European finals, which are based on the European Bioeconomy Venture Forum model, run by the consortium members. A total of 72 high-quality, screened and investment-ready SME are expected to pitch at the two final events. The proposal is based on two consecutive cycles, allowing 350 SMEs to be screened and supported  over the project, with experience from the first cycle being used to improve the project second cycle. The proposal takes account of the difference in Europe in investment activities, the required skills for trainers and the different types of investors in each country. MPowerBIO will ensure that clusters become self-supporting in this respect on completion of the project, with the ability to maintain these skills within their own organisations. The project will produce a replication guide to ensure that project results can be widened to other areas after completion.


**Keywords:** Business support, regional events, workshops, Pan-E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Environmental control by means of a new gas detection principle: gas sensing by metal oxides hetero- junctions' (GASMOH), addressing dissemination and exploitation.

assistant: **Impact**

New miniaturised gas sensor devices, based on metal-oxide heterojunctions, with high sensitivity and stability, will be prepared and characterised. The main goalies the application of the manufactories devices in the field of environmental control for the detection of ozone and combustible gases in urban area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Early POpulations in Cretan History: Investigating residential mobility in the eastern Mediterranean using isotope GeoChemistry' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

EPOCH GeoChem investigates the Neolithic Transition and the subsequent socio-economic developments on Crete (Greece) using a pioneering, multifaceted methodological approach. For the first time, the focus is on the skeletal remains of the respective people; the tools are cutting-edge isotope geochemistry and radiocarbon analyses; the perspective is bioarchaeological and the methodology is novel for this topic. The main objectives are to: a) investigate residential mobility during the Neolithic to Early Bronze Age on the island; b) refine the chronology of the early human occupation of Crete; c) achieve a nuanced reconstruction of the early Cretan bio-cultural history through in-context interpretation of isotopic data; d) create the tools necessary for this and further research on mobility in Europe and the Eastern Mediterranean. For the first time, isotopic analyses of multiple elements (strontium, oxygen, carbon, nitrogen, sulphur and hydrogen) will be used on the same archaeological human remains, including the earliest yet excavated collection from Crete, to determine geographical origins and diet as proxies for distinguishing between different groups, reconstruct mobility and gain insights into the lifeways and social organization of the respective communities. Radiocarbon dating will provide a clear chronological framework. Through the Fellowship the applicant will create critical new knowledge, an innovative methodology and high quality new data for research into the Neolithic Transition and mobility in Europe and the Eastern Mediterranean; establish lasting cross-border academic networks and collaborations; attain the professional maturity required for leading further research advances; educate the public on the benefits of science and motivate the younger genera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BRinging Artificial INTelligencE home for a better cAre of amyotrophic lateral sclerosis and multiple SclERosis' to be submitted under Horizon 2020.

assistant: **Abstract**

Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS) are chronic diseases characterized by progressive or alternate impairment of neurological functions (motor, sensory, visual, cognitive). Patients have to manage alternated periods in hospital with care at home, experiencing a constant uncertainty regarding the timing of the disease acute phases and facing a considerable psychological and economic burden that also involves their caregivers. Clinicians, on the other hand, need tools able to support them in all the phases of the patient treatment, suggest personalized therapeutic decisions, indicate urgently needed interventions.Artificial Intelligence is the key to successfully satisfy these needs to: i) better describe disease mechanisms; ii) stratify patients according to their phenotype assessed all over the disease evolution; iii) predict disease progression in a probabilistic, time dependent fashion; iv) investigate the role of the environment; v) suggest interventions that can delay the progression of the disease.BRAINTEASER will integrate large clinical datasets with novel personal and environmental data collected using low-cost sensors and apps. Software and mobile apps will be designed embracing an agile and user-centred design approach, accounting for the technical, medical, psychological and societal needs of the specific users.BRAINTEASER will implement a system able to guarantee cybersecurity and data ownership to the patients; will provide quantitative evidence of benefits and effectiveness of using AI in health-care pathways implementing a proof-of-concept of its use in real clinical setting. Procedural requirements that support Software as Medical Device certification will be used involving clinicians and patients stakeholders and producing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control'.

assistant: **Innovation**

Recent evidence demonstrates that cancer is overtaking cardiovascular disease as the number one cause of mortality in Europe. This is largely due to the lack of preventative measures for common (e.g. breast) or highly fatal (e.g. ovarian) human cancers. Most cancers are multifactorial in origin. The core hypothesis of this research programme is that the extremely high risk of BRCA1/2 germline mutation carriers to develop breast and ovarian cancer is a net consequence of cell-autonomous (direct effect of BRCA mutation in cells at risk) and cell non-autonomous (produced in distant organs and affecting organs at risk) factors which both trigger epigenetic, cancer-initiating effects. The project’s aims are centered around the principles of systems medicine and built on a large cohort of BRCA mutation carriers and controls who will be offered newly established cancer screening programmes. We will uncover how ‘cell non-autonomous’ factors work, provide detail on the epigenetic changes in at-risk tissues and investigate whether these changes are mechanistically linked to cancer, study whether we can neutralise this process and measure success in the organs at risk, and ideally in easy to access samples such as blood, buccal and cervical cells.In my Department for Women’s Cancer we have assembled a powerful interdisciplinary team including computational biologists, functionalists, immunologists and clinician scientists linked to leading patient advocacy groups which is extremely well placed to lead this pioneering project to develop the fundamental understanding of cancer development in women with BRCA mutations. To reset the epigenome, re-establishing normal cell identity and consequently reducing cancer risk without the need for surgery and being able to monitor the efficacy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multimedia on energy and on semiconductors for european countries.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Features of the proposal: to provide citizens of European countries with an understanding of nature of energy, its transformations, and their impact on modern societies. Objectives: to explain the impact of science and its applications and the benefits to the general public and to young students, diffusing at a European level an activity successfully initiated at national level. The objectives will be achieved through the development of a English and Spanish version of the multimedia course L'energia e le sue trasformazioni", produced by INFM and financed by MPI (both in CD-ROM and on-line formats). The product will be presented at the European S.T. Week 2002, at exhibitions, and used in schools by 10-14 years old pupils. This project is intended to bridge the gap between the general public and scientific and technological knowledge, taking advantage of the effectiveness of multimedia approaches to teaching."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Open Source FPGA Accelerator & Hardware Software Codesign Toolset for CUDA Kernels', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Europe has a strong leadership in the domains of intelligent telecommunications, multimedia, and automotive systems. However, the exponential increase in complexity of intelligent systems threatens the European competitiveness.In order to solve today’s challenges of high-complex design for embedded electronic systems, a number of approaches have been tried. Hardware-software codesign is the first big step and an essential enabling technology towards this end. Electronic System Level (ESL) design methodologies is the next big step which addresses the complexity problem by elevating design to a higher level of abstraction, resulting in a more predictable and productive design process. Finally, parallel hardware platforms such as Graphical Processing Units (GPUs) and Field Programmable Gate Arrays (FPGAs) are becoming very popular within PC-based heterogeneous systems for speeding up numerous compute-intensive applications.FASTCUDA is a platform that provides the necessary software tools, hardware architecture, and design methodology to efficiently adapt CUDA (a parallel-computing architecture and API which is driven by the GPU industry, with wide adoption in many diverse fields ranging from molecular dynamics, to computational chemistry, to image or video processing, etc.) into a new FPGA design flow. With FASTCUDA, the CUDA kernels of a CUDA-based application are automatically partitioned into two groups: some are compiled and executed in parallel software, while the remaining are synthesized and implemented in hardware. A modern low power FPGA provides the processing power (via hundreds of embedded micro-CPUs) and the logic capacity for the implementation of all the software and the hardware components.In particular, we plan to join the numerous on-going efforts in indu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Rat Tools for Functional Genomics' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Determining the molecular basis of natural phenotypic variation, including inter-individual susceptibility to common diseases, is a central challenge of post-genome genetics. The rat is a leading model species for research in physiology, pharmacology and toxicology, and for the study of a wide range of common, genetically complex human diseases. Decades of exquisite phenotyping and detailed analyses in rat experimental crosses have led to localization of hundreds of quantitative trait loci (QTLs) contai ning genes that confer susceptibility to complex disease phenotypes. However in common with studies in other organisms, few genes underlying these genetically complex traits have as yet been identified. The availability of the rat genome sequence and g enome-scale technologies, along with the ability to clone fertile adult rats, has substantially advanced the potential for functional genomics research in the rat model. The European Rat Tools for Functional Genomics (EURATools) consortium draws together leading European researchers in rat genetics, pharmacology, toxicology, disease pathophysiology, and genome biology and informatics. The central aim of this project is the development of integrated genome tools that will generate knowledge which can be translated into improvements in healthcare for highly prevalent diseases in the European Union. The EURATools aims will be achieved by integrating high-throughput sequencing and genotyping with informatics; by intensive analysis of phenotypes, gene seq uence and gene expression in congenic strains to identify genes and regulatory pathways for a wide range of rat disease phenotypes; and by establishment of optimised protocols for rat gene targeting. These new resources will significantly improve our und erstanding of complex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'HOUSING DUALIZATION: DIVIDED HOUSING CAREERS AND THE FINANCIALIZATION OF HOUSING MARKETS'.

assistant: **Objectives**

Recent years have seen a transformation of housing careers. Significant homeownership declines among young adults is evident across Europe, with growing shares in rental or staying on in the parental home. These are not merely symptoms of a temporary recession, but are outcomes of fundamental changes in labour and housing markets alongside shifting state roles. Even in so-called ‘homeowner societies,’ a future of mass homeownership appears unlikely. Rather, we see increasingly divided sectors where insiders have seen sizable asset growth contrasted with significant shares shut out from the housing market. Globally, ‘financialization’ processes have been at forefront of housing market transformation. Financialization describes real forces that have progressively changed the nature of housing, through its integration with global capital flows, neoliberal re/deregulation and increasing commodification: changes that may exacerbate the translation of labour to housing divides. All this, in an era where labour inequalities have increased and housing assets have grown in importance in the face of welfare cutbacks. Given varied homeownership entry, diverging market outcomes, and intergenerational transmission, housing is clearly central to structuring inequalities. Forces of financialization have only amplified the importance of housing towards socio-economic divides. The proposal develops a theoretical and empirical understanding of how European housing is increasingly structured by insider-outsider dynamics - or housing dualization - within contexts of labour inequality and financialization. The quantitative approach is both multi-scalar and interdisciplinary. First addressing macro-level housing divides across national settings, followed by multi-level analyses into individu