RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Polydentate phosphines and their metal carbonyl cluster complexes- units for super-molecular construction and synthesis of new materials' (PDFMCCC), addressing dissemination and exploitation.

assistant: **Impact**

The main goal of the project is to extend transition metal cluster construction beyond the cluster core and to obtain connected polymetallic units by a systematic step-by-step procedure. The proposed approach is based on targeted addition of carbonyl cluster molecules to the specially designed multi-dentate phosphines and subsequent coupling of super-molecules into the larger ones using appropriate ligands/subunits.The project involves the following steps: - synthesis of the family of novel di-, tri- and tetradentate phosphine ligands that possess rigidly arrayed organic backbones, - synthesis of the nanosized super-molecules (length ca. 10nm), constructed of the transition metal clusters (tetra- and octahedral) and the new ligands as linking spacers; in accordance with the architecture of the ligands' backbones three main structural types - chains, layers and 3D - are to be formed upon assembly of the clusters and ligands, - synthesis of the hybrid super-molecules that posses both metal cluster cores and mononuclear metal centre(s) in higher oxidation states, these molecules could serve as blocks for formation of conductive structures consisting of redox-active metal centres, - detailed structural and spectroscopic (NMR, IR, UV-vis, luminescence, fluorescence, ESI-mass) studies of the new compounds.These new compounds are expected to have unusual physical and chemical properties and be important both to academic science and certain practical applications, mainly to nanoscale architecture, optical or electroluminescence device development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Resistance mechanisms in pea to Erysiphe pisi and Uromyces pisi: nitric oxide and induced inaccesibility' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Legumes, particularly pea, are valuable sources of human/animal food. However their yield and quality is constrained by diseases. This project aims to characterise novel disease resistance mechanisms in pea (Pisum sativum) to powdery mildew (Erysiphe pisi) and rust (Uromyces pisi) that can be devastating in regions of pea production. I will investigate inherent resistance and Induced Inaccesibility (II) and Accessibility (IA) to disease. At the cellular level, II and IA describe situations where early pat hogen attacks increase resistance or susceptibility, respectively, to later attacks. II is race non-specific, effective and persistent. Biochemical approaches and studies of differentially expressed gene candidates and proteins will provide insights into t he molecular basis of intra- and intercellular communication within and between tissues. This may reveal novel mechanisms of disease resistance for exploitation through plant breeding. As part of the project, we propose to investigate the involvement of nitric oxide in pea-powdery mildew and rust interaction dissecting its role as signalling molecule not only in inherent disease resistance but also in induced responses. Nitric oxide is emerging as a major signal in plant-pathogen interactions and there is need for spatio-temporal analyses of its role in economically important crop/pathogen interactions. Altogether this project offers a breakthrough in our understanding of the pathogenic interaction between pea and one of the most important constraints on productivity and quality. This should prove of great benefit in the current situation where most single gene controlled resistances to pathogens have been negated by evolution of pathogenic virulence. This has led to increasing reliance on fungicides that are expensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Assessing the role of quercetin-metabolites in improving human vascular health'.

assistant: **Innovation**

This proposal will allow me to be an effective scientist able of developing into a research leader, by exploiting the wider training offered by the Institute of Food Research (IFR, Norwich, United Kingdom). I will have access to many opportunities to play a bigger part in European research, enhancing my future competitiveness as an independent researcher.   Cardiovascular disease (CVD) is a major cause of mortality in the EU. Understanding how diet may prevent the risk of CVD, is a worthwhile target for Europe's citizens. The project is consistent with FP6 Area 5: Food Quality and Safety. Epidemiological studies describe that a diet rich in flavonoids (present in fruits and vegetables) is associated with a decrease in CVD and cancer. Flavonoids are modified during absorption and reach the cells in conjugated forms of the parent aglycones.   The aim of the project is to assess the effect of human flavonoid-conjugates at physiological concentrations on human vascular smooth muscle cells (SMC). Protein and gene expression of vasoactive compounds will be measured by ELISA assay, flow cytometry and Real-time RT-PCR. The use of human flavonoid-metabolites at physiological concentrations is totally innovative and no studies with human vascular SMC have focused on the effect of quercetin-metabolites on the improvement of vascular function. IFR is internationally recognised as a world leader for strategic research in Food Science. It will offer all the facilities required to undertake this project and complementary training. The human flavonoid-metabolites to be used in the project are available at IFR.   This proposal will be an important step forward for my career, allowing me to broaden my research experience and gain new knowledge on a very innovative and important subject i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Nuclear thermo-dynamics'.

assistant: **Innovation**

The statistical multifragmentation model (A. H. Raduta et al.) will be improved such as to take into account the fragment deformation degrees of freedom and to acheive realistic features specific to dynamical simulations. The modification is supposed to r estore the van der Waals shape of the nuclear phase diagram calculated via statistical models. The new version of the model and results of dynamical simlations at frezee-out will be comparatively applied in all evaluations thus contributing to the solidi ty of the obtained results. The phase diagrams of various nuclear systems will be evaluated and their evolution with size, presence or absence of the Coulomb field and isospin will be investigated. The correlation between the position of the system in the phase diagram and the average isospin of the produced fragments and isoscaling will be investigated. Scaling analyses resulting in identifying the system's critical exponents and, consequently its universality class will be performed. The sharp microcano nical heat capacity formulas recently proposed (A. H. Raduta et al.) will be paralelly applied on multifragmentation data and predictions of statistical and dynamical (BUU or QMD) simulations at various moments in time, thus drawing a solid conclusion conc erning the existence of a liquid-gas phase transition in nuclear matter. Finally, an investigation will be made concerning the relevance of the concept of freeze-out. Can one really identify a distinct, statistically equilibrated stage in the process of collision between two heavy ions? Estimators for equilibrium will be designed and their value will be measured in time for the case of dynamical simulations. Whatever the result, this kind of analysis will help in gaining realism concerning the statistical nature of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optical Interrogation of Hippocampal Dentate Granule Circuit Dynamics in Health and Disease' (Circdyn) under Horizon 2020.

assistant: **Objectives**

Understanding the cellular and synaptic basis of memory remains a central goal of modern neuroscience. Physical traces of memory exist as an enduring, experience-dependent change in neural activity in response to learning. In the hippocampus, a key region of the mammalian brain involved in memory formation and recall, new neurons are continually generated in the dentate gyrus (DG) where they form an integral part of the existing functional circuitry. Despite its key position in the hippocampal formation, however, the function of DG and its adult-born neurons in vivo has not been carefully investigated. Here, by applying transgenic and optogenetic approaches – including multicolour genetically encoded activity reporters – together with longitudinal two-photon imaging, we aim to study functional dynamics and plastic changes in DG in health and disorder. We propose that activity patterns in DG cell populations show activity-dependent changes during learning and construct a cellular and circuit basis for contextual memory engrams. We will also investigate how synaptic alterations in excitation-inhibition balance and defects in adult neurogenesis in DG lead to neurological disorders such as Rett syndrome.


**Keywords:** Neural Circuit, Two-photon imaging, Cell-types, Hippocampus, Rett Syndrome, Calcium imaging, MeCP2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Boosting the growth potential of CEE start-ups on a pan-Europen level by creating new opportunities, synergies and opening the GATE of Startup Europe to the Balkans'.

assistant: **Innovation**

The overall concept of MY-GATEWAY builds around the growth potential boost of CEE start-ups on a pan-European level by exploiting the Consortium partners' Startup Europe experience (as former coordinators and partners of the ICT-13 projects) and by implementing actions aimed at creating new opportunities and synergies within and beyond the MY-GATEWAY’s ecosystem. As a result of the project the CEE start-ups and the startup support organizations representing them will have better access to networks, finance and talent and will acquire the necessary skills and knowledge to maximise their growth potential. Moreover, the project will actively contribute to the expansion of the Startup Europe Community by opening the GATE of the Startup Europe to the Balkans. MY-GATEWAY involved the leading startup support organizations from Serbia, Macedonia and Bosnia-Herzegovina (as members of its Balkan Committee) who will continuously follow up the project activities, facilitate the knowledge transfer - MY-GATEWAY KEY - to the Balkan region and mobilize the Balkan start-ups to set up the ""Startup Europe comes to the Balkans"" Network.""


**Keywords:** Innovation ecosystem, synergies, access to finance, access to talents, capacity building, access to networks, procurement, scaling up, knowledge transfer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Transforming Agri-Food By-Products into High-Nutritional Value, Sustainable Proteins and Ingredients' in the context of a Horizon Europe call.

assistant: **Objectives**

MOA Foodtech: Pioneering Sustainable Food SolutionsFounded in 2020, MOA Foodtech is revolutionizing the food industry by creating sustainable proteins and ingredients to address global challenges. Backed by €4.26 million in venture capital and €1.928 million in grants, we are supported by leading investors like Barilla and ICOS Capital. With 27 pilot projects and 5 license agreements with major players like Nestlé and Barilla, MOA is shaping the future of food production.The Global Food ChallengeBy 2050, the world’s population will hit 9.2 billion, driving a 70% increase in protein demand. Traditional agriculture, which already occupies 77% of global farmland and contributes up to 30% of greenhouse gas emissions, cannot sustainably meet this need. MOA’s solution offers an alternative through innovative fermentation techniques, drastically reducing environmental impact.MOA’s Breakthrough TechnologyOur Non-GMO Directed Fermentation platform combines the benefits of both biomass and precision fermentation, without regulatory delays. Powered by our AI platform, Albatros, it allows us to produce high-quality, customizable ingredients using pre-approved microorganisms, ensuring faster, cost-effective production. This innovation positions us as a leader in sustainable food ingredients, with products that are scalable and market-ready.High-Growth PotentialMOA operates in the fast-growing €511 billion food ingredients market, targeting a Serviceable Obtainable Market of €516 million in Europe and North America. We seek €2.258 million in grant funding and €12.5 million in equity from the EIC Accelerator to scale production and drive commercialization. With our cutting-edge technology and a clear growth strategy, MOA is set to lead the future of sustainable food innovation.


**Ke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multimodal imaging of spatial attention networks in the human brain' in the context of a Seventh Framework call.

assistant: **Objectives**

Neglect, extinction and simultanagnosia constitute a group of debilitating disorders of spatial attention frequently associated with right hemisphere damage. A fronto-parietal distributed network for attention has been described but many questions remain to be answered. One major problem is the difficulty in translating anatomical information derived from animal studies to humans. Until recently there has been no direct way of studying anatomical connections or dynamic interactions between cortical areas in man. Hence, this projects aims at defining the anatomical and dynamic details of the spatial attention networks in the living human brain using state-of-the-art methodology to image connectivity. 3 different but complimentary connectivity measures will be used. Diffusion tensor tractography (DTT) allows the study of white matter connections in the living human brain. Functional magnetic resonance imaging (fMRI) connectivity measures (e.g. dynamic causal models DCM) offer a dynamic picture of connections on a time scale of several seconds. Electroencephalography (EEG) measures extend to a shorter time scale and are sensitive to interactions between cortical areas invisible to fMRI methods. The project has three overall objectives: i) to develop a novel multimodal imaging methodology allowing unprecedented access to the in-vivo anatomical, functional and dynamic characteristics of a large scale neurocognitive network. ii) to bridge the gap between monkey and human connectional anatomy in the field of attention iii) By proposing a dynamic anatomical framework we hope to understand the clinical heterogeneity of disorders of spatial attention, helping clinicians predict recovery and plan patient-specific therapeutic strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Directed Evolution of Small-Molecule Cancer Therapeutics'.

assistant: **Objectives**

Cancer imposes a tremendous socioeconomic burden in modern societies, causing ~1.7 million deaths in the EU annually. 15-20% of these cases occur due to mutations in the oncosuppressor gene p53, which destabilize the protein and inactivate its ability to mediate apoptosis under physiological conditions. Today, no drugs exist which can restore the function of mutant p53 and treat cancer. The present proposal deals with the discovery of potential cancer therapeutics of this type. The topic of the proposed research is the directed evolution of small molecules which can bind to and restore the folding and function of destabilized oncogenic variants of p53 (p53*). These compounds will be selected from libraries of small molecules which will be biosynthesized in microbial cells. Biosynthesis will be carried out using an approach that allows for facile preparation of a very large number of test compounds, which will exhibit high levels of chemical and structural diversity. These small-molecule libraries will then be screened and the compounds which can bind to and improve the folding of p53* will be identified using a high-throughput genetic screen. The effect of the identified compounds on the stability of p53* will be subsequently evaluated in vitro by using biochemical and biophysical methods of protein analysis, and their ability to revitalize apoptosis will be tested in selected human cancer cell lines. The compounds which will be found capable of restoring the stability and apoptosis-mediating function of p53* will become drug candidates against a broad panel of cancers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Suspended Life: Exploring Cryopreservation Practices in Contemporary Societies' under Horizon 2020.

assistant: **Concept**

Cryopreservation practices are an essential dimension of contemporary life sciences. They make possible the freezing and storage of cells, tissues and other organic materials at very low temperatures and the subsequent thawing of these at a future date without apparent loss of vitality. Although cryotechnologies are fundamental to reproductive technologies, regenerative medicine, transplantation surgery and conservation biology, they have largely escaped scholarly attention in science and technology studies, anthropology and sociology. CRYOSOCIETIES explores the crucial role of cryopreservation in affecting temporalities and the concept of life. The project is based on the thesis that in contemporary societies, cryopreservation practices bring into existence a new form of life: “suspended life”. “Suspended life” enables vital processes to be kept in a liminal state in which biological substances are neither fully alive nor dead. CRYOSOCIETIES generates profound empirical knowledge about the creation of “suspended life” through three ethnographic studies that investigate various sites of cryopreservation. A fourth subproject develops a complex theoretical framework in order to grasp the temporal and spatial regimes of the different cryopractices.CRYOSOCIETIES breaks analytical ground in three important ways. First, the project provides the first systematic and comprehensive empirical study of “suspended life” and deepens our knowledge of how cryopreservation works in different settings. Secondly, it undertakes pioneering work on cryopreservation practices in Europe, generating novel ways of understanding how “suspended life” is assembled, negotiated and mobilised in European societies. Thirdly, CRYOSOCIETIES develops an innovative methodological and theoretical framework
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Blue Revolution - a two part popular science tv-documentary on marine aquaculture' (BLUR) targeting Fifth Framework.

assistant: **Abstract**

Our main objective is to raise public awareness about marine aquaculture: its products, its effects on health and environment, and its role in a future, sustainable economy. The title suggests the perspective: Will aquaculture be a blue revolution", comparable to the agricultural revolution in neolithic times? This question is important if we consider the population growth, and the increasing pressure on key resources and ecosystems. This, along with the health aspect of seafood consumption, makes aquaculture highly relevant both today and in the future.The project is important because it will be the first effort of its kind, with help from leading researchers in the field. The production will be done at The University Media Centre, Bergen, an established producer of scientific and educational TV programmes on public channels (also international)."