RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Peptidomimetics with photocontrolled biological activity'.

assistant: **Objectives**

The expertise, resources and specific knowledge of all participating parties will be combined to achieve a breakthrough in design, synthesis and application of peptide analogues (peptidomimetics) possessing photo-controlled biological activities, with special emphasis on anti-microbial and anti-cancer activities. The main idea behind the Project consists in chemical incorporation of artificial photo-controllable building blocks into known biologically active peptides by replacing their natural building blocks – the amino acid residues. Such a modification would provide photocontrolled  peptidomimetics which can reversibly change their structure between two different photo-forms upon irradiation with light of different wavelength. The participating parties possess general know-how for design of the peptidomimetics which can exist in two photo-forms, biologically active and inactive ones, reversibly interconvertible by light of different wavelength. This opens a possibility to convert inactive peptidomimetics to active compounds by irradiation with physiologically benign light directly in tissues with very high spatiotemporal precision and can be a fundamental basis of new therapeutic strategies. The research staff exchange and other activities planned under the Project will be dedicated to accomplish four complementary work packages: (i) carrying out pharmacokinetic and toxicity studies of the photocontrolled peptidomimetics synthesized by the parties previously; (ii) evaluation of novel photocontrolled building block chemotypes for their compatibility with peptides; (iii) creation of new photocontrolled peptidomimetics, especially based on the novel building blocks and the know-how developed by the parties (e.g. using “stapled peptides” technology); (iv) multidisciplina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cyclopes: satellite products for change detection and carbon cycle assessment at the regional and global scales' (CYCLOPES).

assistant: **Concept**

The CYCLOPES project will develop and validate biophysical products (albedo. LAI. fAPAR, fCover) from large swath sensors (AVHRR, VEGETATION, POLDER, MERIS , MSG). The products will result from the fusion of concurrent sensor observations when available and will aim at providing long, continuous and consistent time series. Global fields of these variables and the associated uncertainties will be produced over the 1997-2002 period, with a 10 days temporal resolution and a spatial resolution between 1 to 8 kilometres. The use of these products will then be demonstrated for two main applications in relation to climate change: - The detection and categorization of land use change detection,- The estimation of carbon fluxes for the improved description and understanding of the interactions between the vegetation and the atmosphere.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Novel BERberine derivative for Malignant MESothelioma' (BERMES).

assistant: **Concept**

Malignant Mesothelioma (MM) is a rare, aggressive and highly treatment-resistant malignancy arising in the thin layer of tissue known as mesothelium, which covers many of the important internal organs like the lungs, the peritoneal cavity, the heart and the testis.The World Health Organization has recognized that all forms of mesothelioma are strongly associated with asbestos exposure and that its burden is increasing worldwide. Asbestos was definitely banned in European Union in January 2005. However, since the disease has a long latency period (44.6 years from exposure to diagnosis), peak incidences are expected in EU beyond 2020.The standard first line treatment is the combination of pemetrexed and cisplatin with limited efficacy and side-effects. Despite a great deal of research has been undertaken during the last 10 years, none of the current drugs under clinical trials has shown yet an improvement in overall survival over existing standard therapy or solved the emergence of chemoresistance.NAX035, an innovative berberine derivative has exhibited efficacy as antitumour agent with a good preliminary pharmacokinetic, toxicity and safety data when administered as oral therapy for the treatment of malignant mesothelioma.  Activities of BERMES (BERberine derivative for MESothelioma treatment are expected to close the translational gap (death valley) by pulling the product up to the clinical development: BERMES will focus on completion of the non-clinical package and the drug manufacture with the aim of obtaining the orphan drug designation as well as to accomplish all the regulatory requirements required by the European Medicine Agency to achieve the clinical trial authorization to proceed into clinical trial right after the end of the project.


**Keywords:** berberine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring neuro-glymphatic coupling during sleep using wearable technology' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In recent years, it has been demonstrated that sleep not only plays a crucial role in cognitive, emotional, and immunological functions but also helps to clear the brain from metabolic waste products via the recently discovered glymphatic system. A physiological marker closely associated with glymphatic clearance is electroencephalographic (EEG) slow-wave activity (SWA, 1-4 Hz). An increase in SWA, driven by high sleep pressure accumulated during the day, is related to a boost of glymphatic clearance. In humans, such temporal neuro-glymphatic coupling has been confirmed by using a combination of sleep EEG and functional magnetic resonance imaging (fMRI), which, however, is challenging to use in sleeping subjects. Recently, a first wearable solution has been developed that allows simultaneous assessment of brain electrophysiology and glymphatic system activity by using a combination of the sleep EEG and non-invasive functional near-infrared spectroscopy (fNIRS). This unique technological solution provides an opportunity for the investigation of neuro-glymphatic coupling in sleep without disturbing natural sleep.SWA can be boosted by the well-timed presentation of brief auditory stimuli during sleep without otherwise altering natural sleep architecture. This approach is referred to as closed-loop auditory stimulation (CLAS) and has gained a lot of attention from both sleep researchers and the industry. Given that deep sleep is a primary driver of glymphatic clearance, it is of great importance to establish if CLAS can boost glymphatic activity along with SWA enhancement. Evidence for the modulatory effect of CLAS on glymphatic clearance will open new avenues for future implementations of CLAS for prevention and/or therapy of neurodegenerative disorders. For instance, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Non-invasive patterned electrical neurostimulation of the retina'.

assistant: **Objectives**

Retinal implants remain one of the most demanding technologies in brain-machine interfacing. State of the art devices have yet to reach the needed performances. Main barriers are sub-optimal stimulation parameters and long development and testing procedures. While invasive approaches, have yet to achieve the resolution performances needed by million of patients blinded by retinal degenerative diseases, non-invasive approaches in the form of trans-orbital stimulation have received no attention, yet they offer potentially dramatically cheaper and easy to adapt and optimize technology.    The main goal of this project is to advance the field of retina neurostimulation by developing new tools for the study and interfacing with the retina. In particular: (1) Bi-directional electrophysiological interface which can record and stimulate the intact retina (in the eye) and (2) soft multi-electrode arrays for non-invasive stimulation of the retina (soft trans-orbital electrodes) will be explored. We will use these tools to study the retina in its intact form (in animal models) and we will implement the gained know-how in humans to study non-invasive stimulation. In this project we will establish a new platform for bi-directional electrophysiological interfacing with the intact retina and we will use it to study the retina in its intact form. Such investigations have ground breaking nature as they can advance both the fundamental understanding of the retina and improve the manner by which we stimulate the retina to generate artificial vision: Specifically, we aim to record spontaneous waves activity and light sensitive ganglion cells, optimize electrical stimulation parameters in the intact retina, and ultimately to measure retina responses to trans-orbit stimulation. As the ultima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative Industrial Process for printing Lenticular Images Directly on Textiles with Jetting Technology for safety (protective clothing) application' in the context of a Seventh Framework call.

assistant: **Objectives**

In Europe 16 Million workers operate in low visibility environments, including roadway construction personnel and vehicle operators, utility workers, survey crews, emergency responders, railway workers and accident site investigators, school crossing guards, parking and toll gate personnel, airport ground crews and law enforcement personnel directing traffic, parking service attendants, workers in warehouses with equipment traffic, shopping cart retrievers, sidewalk maintenance workers, and delivery vehicle drivers, to name a few. Statistics report that every year 6000 are injured by vehicles or human operated equipment, because of a lack of visibility, specially in night time operations. To address this issue and minimise accidents, the EU launched directives 89/656/EEC and 89/686/EEC, which oblige employers to make available high visibility clothes to their employees. State-of-the-Art solutions consist in applying reflective material stripes onto the garment surface. Lion-tex suggests an innovative product for high visibility garments, which exploits the lenticular effect. In the project three objectives are defined: first of all to develop a portfolio of innovative 3D lenticular effects, that will be exploited on 3D surfaces (like textiles) instead of flat substrates; second objective is to develop an industrial plotter for textiles that allows, all at once, the printing of interlaced images made of reflective and fluorescent ink and the deposition of resins through a jetting device for constructing the lenticular layer; finally a new set of high visibility garments will be prototyped, demonstrating not only the higher efficiency of this product in protection, but also the lower cost, with respect to the state of the art, for a stronger SMEs competitiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SOlutions TEsting for Regions through Insurance for climate Adaptation' (SOTERIA).

assistant: **Innovation**

The SOTERIA project aims to advance innovative insurance solutions for climate change adaptation in different European regions and communities. To do so, SOTERIA will work through three main tracks forming the core of our approach: i) documenting best practice in relation to data, new insurance and robust enabling frameworks; ii) testing of some of these solutions; and iii) the creation of communities of practice for regions and insurance as legacy. We aim to help reducing the protection gap by documenting best practice and the testing of insurance products and services that reward proactive prevention measures while seeking to increase coverage through co-designed solutions. We will also consider the enabling framework that analyses the role of public sector modernisation and how to develop affordable insurance schemes that leave no one behind, through our Communities of Practice engaged in Climate Resilience society-insurance dialogues. SOTERIA will take these solutions from the levels of research to demonstration and testing with some at the level of pre-commercial procurement in at least three cases thanks to a network of three pilots and 5 satellites that span different geographical areas (and needs). The project legacy a set of best practice materials  as well as a Community of Practice to support other regions interested to design and/or adopt innovative insurance solutions. SOTERIA will contribute to the wider goal of the Mission Adaptation to increase Europe’s resilience and preparedness to face unavoidable consequences of climate change by filling the gaps on insurance coverage for climate adaptation.


**Keywords:** Best practice,  Testing,  innovative Insurance Solutions, Enabling Framework
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'iPROLEPSIS: PSORIATIC ARTHRITIS INFLAMMATION EXPLAINED THROUGH MULTI-SOURCE DATA ANALYSIS GUIDING A NOVEL PERSONALISED DIGITAL CARE ECOSYSTEM' (2021-2027).

assistant: **Innovation**

Psoriatic Arthritis (PsA) is a chronic, progressive, inflammatory disease affecting 1-2% of the general population, while manifesting in up to 30% of people with psoriasis (PsO). The transition from health to PsA is currently untraceable; diagnosis of early PsA is challenging even in PsO patients. Untimely diagnosis is common and contributes to early deterioration of quality of life, also increasing the burden of the multiple comorbidities associated with PsA. In this vein, iPROLEPSIS aspires to shed light upon the health-to-PsA transition with a comprehensive multiscale/multifactorial PsA model employing novel trustworthy AI-based analysis of multisource and heterogenous (i.a., in-depth health, environmental, genetic, behavioural) data, digital phenotyping of inflammatory symptoms with emphasis on tracking of motor manifestations using smart devices and wearables, novel optoacoustic imaging-based markers of PsA in the skin and joints, and investigation of the role of mast cells in the PsA transition, to identify key drivers of the disease and support personalized models for PsA risk/progression prediction and monitoring as well as associated inflammation detection and severity assessment. To ultimately advance PsA diagnosis and care, the models will be translated into a digital health ecosystem comprising dependable tools for supporting healthcare professionals in disease screening, monitoring and treatment via quantitative, explainable evidence, and empowering people with/at risk of PsA with tailored insights and preventive interventions based on actionable factors for educated health management. The project will steer its research and development efforts following a trustworthy framework for ethical, lawful, and robust AI, and a user-centered co-creation approach bas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Elucidation of the function of DDX3X in innate immunity' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Viral infections are among the most frequent causes of human diseases and affect most people worldwide. While some viral diseases have been successfully combated, novel viral diseases like AIDS, SARS, avian influenza A H5N1, or the swine influenza A H1N1, have emerged over the last decades. Research aiming at elucidating mechanisms of viral infection and the involved immune response is, therefore, of utmost importance in order to understand viral pathogenesis and to identify novel potential drug targets. The goal of this proposal is to define the role of the RNA helicase DDX3X in the regulation of IFN-I expression. IFN-I is a central player of innate immunity and its secretion is rapidly induced upon stimulation of various receptors of the innate immune system, known as pattern recognition receptors. The current proposal aims at generating mice that lack functional DDX3X protein in specific tissues. We will test the ability of various cell types or DDX3X mutant mice to elicit effective IFN-I responses and we will assess the susceptibility to viral infections. Finally, we will examine the effect of DDX3X in acute lung injury, the main cause of death in individuals infected with SARS or influenza virus. These experiments are designed to reveal essential in vivo functions of a novel key molecule implicated in viral infections and therefore should contribute to the understanding and molecular consequences of the cellular host response to virus infections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Organization of the annual CAPS international conference in the context of Horizon 2020' under Horizon 2020.

assistant: **Concept**

Through Call 10 the European Commission will support the development of many CAPS (Collective Awareness Platforms for Sustainability and social Innovation) STREP, IP, and CSA projects of diverse nature and focus. It is also expected that the CAPS topic will be given even greater importance in the first Calls of Horizon 2020.<br/>In this context of emergence and diversity of CAPS, and in order to reach a strong momentum that Horizon 2020 will amplify, it is important that an annual international conference focusing on CAPS can be organised, providing all CAPS projects with an opportunity to increase their visibility and impact in Europe and beyond, and to liaise with any interested stakeholders, including organizations developing similar projects in other regions of the world.<br/>These annual events will be key milestones in the present CAPS booming period, allowing to address issues of common interest, to develop synergies betweeninitiatives, and to discuss the CAPS research roadmap for Horizon 2020,<br/>The organization of these annual events is the main objective of the CAP2020 project. Two events (in 2014 and 2015) will be organized during the projectlifetime (24 months) in Brussels, so that a large participation from EC officials and other key institutions based in Brussels can be foreseen.<br/>These events will be organised in continuity with the 1st Dialogue on platforms for collective awareness and action" held in Brussels in September 2011 and organized by Sigma (CAP2020 coordinator) in the framework of the PARADISO2 FP7 project (see paradiso-fp7.eu) which Sigma has coordinated over the period 2010-2011, this "Dialogue" having been to a large extent the driver of the inclusion of a CAPS topic in Call 10.<br/>Close liaison with the CAPS Unit & the CAPS project p