RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reliability and effectiveness of integrated alternative water resources management for regional climate change adaptation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

RECREATE aims to improve the resilience of water supplies and protect the status of natural water resources by facilitating the assessment and inclusion of Alternative Water Resources (AWR) in water management planning for water scarce regions, and to increase awareness and acceptance of and trust in the fundamental role of AWR in climate change adaptation. RECREATE will produce an open access repository compiling knowledge and data on the cost-efficiency, environmental and health impact of different technological and water management alternatives. This repository will be encoded as an independent module into a Digital Decision Support Framework (RECREATE_WT) that, together with 3 additional modules covering climate change impact predictions, adaptation strategies to local context and a decision matrix will be used for co-creating adaptative pathways for water management. RECREATE_WT will compile and assess information on water availability and demand for a given region and organise knowledge on the performance of innovative treatment technologies. It will explicitly consider human health risks associated to potable use, local context (regulatory, cultural, spatial and socio-economical aspects) and water management strategies under different stress scenarios. The tool will provide a decision matrix for pathways creation,thus RECREATE_WT will  act as a knowledge orchestrator and a decision theatre environment for co-designing water resource planning pathways  RECREATE_WT will be demonstrated in 4 regional case studies (CS) covering different bio-regions (Mediterranean, Continental and Atlantic), and water contexts. CS will focus on the digitalization of the water cycle for integrated water management while demonstrating the cost-effectiveness  reliability and safety of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'VERtical Innovation in the Domain of Robotics Enabled by Artificial intelligence Methods' (VeriDream), addressing dissemination and exploitation.

assistant: **Impact**

Advances in artificial intelligence (AI) are changing the business models of many companies, and creating entirely new ones. But whereas the general public associates AI predominantly with autonomous and humanoid robots, the economic impact of AI on robotics has been very limited in comparison to domains which were digitised from the start, such as Internet search and social networks. This is because acting in the physical world raises many challenges related to the variability of the real world, its continuous and dynamic nature, as well as the consequences of suboptimal or erroneous behaviour.To address these challenges, VeriDream proposes a two-fold research and innovation strategy for AI in robotics, based on the generalisation and robustification of AI methods developed by the three research partners in two previous H2020 projects, DREAM and RobDREAM. The deep innovation strategy aims at high TRL on a set of use cases from the specific domain of warehouse logistics at the start-up Magazino. The broad innovation strategy, pursued by Synesis and GoodAI, aims at fostering a broader uptake of DREAM methods in SMEs, also beyond the project, and even beyond robotics. VeriDream thus aim at both concrete high-TRL innovation success stories, as well as providing experience and templates for innovation from which other European SMEs may profit.In both strategies, our methodology is based on ""closing the innovation loop"". This means that research on AI methods is driven less by performance on static benchmarks, but rather by general methodological requirements derived from the performance on multiple industrial use cases. This will require scientific advances in state representation learning, failure discovery and resolution, and  continual learning. The generalisation and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Breakthrough in micro-bolometer imaging' in the context of a Horizon Europe call.

assistant: **Objectives**

Micro-bolometer sensors are compact, light, low power, reliable and affordable infrared imaging components. They are ahead of the cooled infrared sensors for these criteria but lag behind them in terms of performance:- Existing micro-bolometer technologies have thermal time constants around 10 msec. This is more than 10 times that of cooled detectors. - Moreover, there is no multispectral micro-bolometer sensor available today for applications such as absolute thermography and optical gas imaging.BRIGHTER will develop 2 new classes of micro-bolometer solutions to reduce the performance gap with their cooled counterparts: - Fast thermal micro-bolometer imaging solutions with time constant in the 2.5 to 5 msec range, that is to say 2 to 4 times faster than that of today’s micro-bolometer technologies. Read out integrated circuits able to operate up to 500 frames per seconds will also be investigated.- Multi-spectral micro-bolometer solutions with at least access at the pixel level to 2 different wavelengths in the range 7 to 12 µm.The developments will focus on pixel technology, Read Out Integrated Circuit, low power edge image signal processing electronic, optics, and image treatment algorithms. All stakeholders of the value chain are involved: academics, RTO, micro-bolometer manufacturer, algorithm developers, camera integrators and end users. They will collaborate to define the best trade-offs for all use-cases.The 2 new classes of products that will spring from BRIGHTER will generate concrete benefits. They will make it possible to save on material and energy in the manufacturing sector, perform efficient and affordable monitoring of infrastructures and trains,  contribute to autonomous vehicles sensor suite, decrease the road casualties among Vulnerable Road Users, b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DiAMonD - DIscovering Active MicroOrgaNisms implicated in adverse Drug effects' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The microbiome plays relevant functions on human health and disease, including roles in the efficacy and security of drug treatments. Capecitabine is a pro-drug of 5-fluorouracil, which is an active metabolite that targets tumor cells. This treatment is used for diverse cancers, including colon tumors, and is commonly associated with diverse adverse reactions such as the hand-foot syndrome (HFS), a skin deterioration for which there has not been discovered its causal mechanism. Preliminary data suggest that some skin microbes interact with 5-flourouracil.Here, I aim to study the dynamics and features of the skin microbiome of patients treated with capecitabine. Using massive parallel sequencing methods, I will look for microbial taxa, genes and/or functions associated with the presence/absence of HFS adverse reaction. Based on those data, I will select appropriate conditions to isolate microbial taxa likely implicated in HFS and I will study their ability to metabolize capecitabine and 5-florouracil. Then, with those microbes showing this activity, I will analyze their genomes and transcriptomes in presence/absence of these drugs to select candidate genes involved in this drug metabolism. Afterwards, I will perform docking methods to decipher more precisely the likelihood of the encoded protein to interact with the drug. Finally, I will validate this data with the phenotypic study of knock-out mutants lacking selected genes likely implicated in the drug metabolism.This project will provide understanding related with the roles of the skin microbiome in the appearance or protection against a skin adverse drug reaction. This knowledge may be used for the advance of a precise and personalized medicine in which the individual microbiome can be considered. The proposed projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Textile-based Wearable Mechanotheraphy Device with Liquid/Vapor Phase Change Actuation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Soft Tissue Manipulation (STM) is a powerful and direct form of mechanotherapy, which has significant implications in physical rehabilitation, disease prevention and health promotions. Different types of devices for manipulating muscle tissue have been developed for clinical applications and pneumatic compression devices are already in the market and widely used. However, these systems have limited control modalities and lack of monitoring the forces being exerted to the body during the application and previous studies have shown that the loading conditions of soft tissue have a crucial effect on the mechano-therapeutic treatment. One of the main drawback of the pneumatic compression systems is they do need rigid and bulky pumping systems for the implementation of mechanotherapy and this requirement greatly reduces the mobility of the device. Furthermore, rigid-body industrial robotic manipulators have also been used for mechano-therapeutic applications. Although these systems have the ability to perfectly manipulate soft tissue and apply controlled forces, they are expensive and do not enable safe human-device interaction due to their rigid nature. Overall, to address the challenges above I will employ textile materials to achieve both sensing and actuation with the help of phase change property of low boiling point liquids. The textile-based approach will lead to system that are lighter and mobile and safe for human-device interaction. Its successful completion will contribute to the acceleration of the soft tissue providing better and more effective therapies in terms of wearability comfort, mobility and power consumption. By combining my existing skills with newly acquired skillset that will be gained during the fellowship I will have an opportunity for securing a p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Alphaviral Immunotherapy against Glioblastoma' (AVITAG), addressing dissemination and exploitation.

assistant: **Impact**

Alphaviral Immunotherapy against GlioblastomaGlioblastomas (GBM) are the most frequent type of primary brain tumours with no treatment or cure available. Despite the current standard care, GBMs remain 100% fatal with median survival of patients for only 12 - 15 months. Thus, there is an urgent need for novel effective therapies.Among the emerging new therapeutic approaches is oncolytic virotherapy with replicative viruses that kill cancer cells. During his PhD studies, the applicant researcher, Miika Martikainen, has engineered novel tumour-targeted replicative alphavirus that shows promising therapeutic response in a syngeneic orthotropic mouse model for human GBM. As the next step, the applicant seeks to join Professor Magnus Essand’s group at the Uppsala University to conduct his postdoctoral research project that aims to development of clinically relevant oncolytic immunovirotherapy against GBM.To achieve this aim, previously unappreciated potency of Alphaviral oncolytic virotherapy is combined with synergistic immunotherapy with dendritic cell vaccination and/or adenoviruses. A detailed analysis of relevant immune responses associated with the therapy efficacy will be conducted to allow clinical translation of the results. The state-of-the-art methods available and the training received during the fellowship at host laboratory and secondments will arm the applicant with the skills and knowledge that allow him to establish a career as independent research scientist in a field that aims to develop novel ways to treat severe forms cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Detoxifying alcohol in the wild- Investigating convergent evolution among butterflies feeding on fermenting fruits'.

assistant: **Objectives**

Key innovations allow organisms to exploit novel resources fuelling rapid diversification. Fermenting fruits have higher nutritional value, for example, than nectar, and their consumption provides higher fitness benefits. However, the high alcohol concentration in fermenting fruits reaching up to 8% can be detrimental, making them a challenging resource. Nevertheless, diverse animals feed and breed on fermenting fruits using the alcohol detoxification system, yet little is known about how this convergent phenotype evolved. Such systems allow addressing key questions at the heart of evolutionary biology: what ecological drivers triggered shifts to feeding on fermenting fruits? Are such shifts key innovations? At what level of genetic mechanism do the diverse animals feeding on fermenting fruits show convergence in the alcohol detoxification system? These questions can only be answered using a large-scale, integrative and comparative evolutionary framework, yet studies remain focused on within populations of few taxa. My proposal seeks to answer these outstanding questions using the rich model system of butterflies, to quantify the ecological and genetic mechanisms underlying diet evolution (fermenting fruits vs nectar). My three main objectives are to: (1) Unravel the macroevolutionary patterns of convergence in dietary shifts and quantify impacts on diversification, (2) Conduct a comparative sequence analysis of the alcohol dehydrogenase gene and its enzyme across fruit and nectar feeders, and (3) Test hypotheses on the effects of dietary alcohol on fitness and gene expression in a fruit and nectar feeder. I will integrate information on butterfly natural history with methods from comparative phylogenetics, genomics, and experimental approaches to achieve my objectives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ruthenium-containing Polymers against Ovarian Cancers' (RuCoPOC) under Horizon Europe.

assistant: **Objectives**

Nearly 250,000 women are diagnosed each year with ovarian cancer around the world, resulting in 140,000 deaths. High-grade epithelial ovarian cancer (EOC) is the deadliest gynecologic cancer, ranking fifth overall in cancer deaths. The majority of women have widespread intra-abdominal disease at the time of diagnosis, and the 5-year survival rate for these women is only about 40% after receiving standard therapy. Currently, the standard first-line treatment for ovarian cancer consists of surgical cytoreduction and platinum-based chemotherapy. Although this approach has proven to be the most effective treatment to date, many ovarian cancers exhibit primary platinum resistance, and most patients develop secondary platinum resistance during the course of their disease. There is therefore a paucity of approved targeted therapies. Accordingly, effective novel therapies are needed to improve survival rates for patients diagnosed with ovarian cancer, especially in its advanced stages and in the setting of platinum resistance. The phenomenal success of cisplatin, oxaliplatin and carboplatin has boosted the research directed at novel metal-based anticancer drugs. My group has embarked a few years ago into a program to thoroughly investigate Ru compounds as anticancer drug candidates. However, one serious problem of metal-based drugs is often their intrinsic toxicity. To tackle this issue and circumvent these limitations, macromolecular delivery systems can be used to improve the potential of the respective anticancer ruthenium complexes. During the frame of the ERC consolidator grant PhotoMetMed, my group could demonstrate that an innovative drug-initiated polymerization methodology could be used to tackle this problem. In this proposal, to further demonstrate that this technolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automated Synthesis of Heparin and Chondroitin Libraries for the Preparation of Diverse Carbohydrate Arrays' (AUTOHEPARIN) targeting Seventh Framework.

assistant: **Abstract**

While heparin, a glacosaminoglycan (GAG) has served as an anticoagulant for more than 60 years, the structure-activity relationship of heparin and chondroitin sulfate for specific interactions with proteins are still poorly understood. It has become evident that defined lengths and sequences or patterns are responsible for binding to a particular protein and modulating its biological activity.  Determination of the structure-activity relationships of heparins and chondroitins creates an opportunity to modulate processes underlying viral entry, angiogenesis, kidney diseases and diseases of the central nervous system. The isolation of pure GAGs is extremely tedious and chemical synthesis is often the only means to access defined oligosaccharides. Currently available synthetic methods for the preparation of heparins and chondroitins are time consuming and lack generality. Therefore, it is still impossible to create large collections of GAG oligosaccharides for systematic studies of GAG-protein interactions.  The overall goal of the project is the development of all aspects of automated GAG synthesis, the procurement of a large collection of heparin and chondroitin oligosaccharides of 2-10 sugars in length with a linker for ready attachment to microarray surfaces and other tools. These molecular tools will be employed to study the interaction of GAGs with growth factors, chemokines and other proteins. The specific aims include: 1) Synthesis of uronic acid and galactosamine building blocks; 2) Development of a new linker for automated GAG solid phase synthesis; 3) Construction of a new automated oligosaccharide synthesizer; 4) Development of methods for the automated assembly of heparin and chondroitin sulfate oligosaccharides; 5) Synthesis of a collection of defined heparin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ideology in Context: An Agential Approach to the Study of Houthism' in the context of a Horizon Europe call.

assistant: **Objectives**

The stellar rise of the Yemen’s Houthis (Ansar Allah) is not just a story of military conquest but also of ideological innovation, which has transformed northern Yemen and reshaped power relations in the Middle East. Despite their importance, the unanswered question of what the Houthis “really” want still looms large in academic debates and political circles. This project will transform our understanding of the Houthis by analysing their massive ideological output and triangulating it with a vast corpus of unexplored indigenous sources and findings from digital (remote) fieldwork. As the first study of its kind, this project pursues three primary objectives: (1) Provide unprecedented insights into Houthi ideology and its interplay with Yemen’s social, intellectual, historical, religious, and institutional frameworks, including its foreign inspirations, media, and symbolic and ritual expressions. (2) Explore Houthi ideology’s dual nature as both a normative discourse and an everyday practice, offering empirically informed understandings of how ideology operates and impacts local communities, and (3) use Houthi ideology as a case study to develop a novel “agential” and multiscalar theoretical approach to the study of ideology within social and cultural anthropology, and related fields.The results of this project will redefine the anthropology of ideology and provide unparalleled insights into the Houthi phenomenon. Its innovative theoretical and methodological contributions will advance social and cultural anthropology, enhancing its relevance and providing novel approaches and tools for studying emerging ideologies in similar contexts globally. On a trans-disciplinary level, the results will inform and revise diplomatic, political, and humanitarian efforts to better unde