RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BIOMIMETIC FIXATION OF CO2 AS SOURCE OF SALTS AND GLUCOSE' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The continued increase in the atmospheric concentration of CO2 due to anthropogenic emissions is leading to significant changes in climate, with the industry accounting for one-third of all the energy used globally and for almost 40% of worldwide CO2 emissions. Fast actions are required to decrease the concentration of this greenhouse gas in the atmosphere, value that has currently reaching 400 ppm. Among the technological possibilities that are on the table to reduce CO2 emissions, carbon capture and storage into geological deposits is one of the main strategies that is being applied. However, the final objective of this strategy is to remove CO2 without considering the enormous potential of this molecule as a source of carbon for the production of valuable compounds. Nature has developed an effective and equilibrated mechanism to concentrate CO2 and fixate the inorganic carbon into organic material (e.g., glucose) by means of enzymatic action. Mimicking Nature and take advantage of millions of years of evolution should be considered as a basic starting point in the development of smart and highly effective processes. In addition, the use of amino-acid salts for CO2 capture is envisaged as a potential approach to recover CO2 in the form of (bi)carbonates. The project CO2LIFE presents the overall objective of developing a chemical process that converts carbon dioxide into valuable molecules using membrane technology. The strategy followed in this project is two-fold: i) CO2 membrane-based absorption-crystallization process on basis of using amino-acid salts, and ii) CO2 conversion into glucose or salts by using enzymes as catalysts supported on or retained by membranes. The final product, i.e. (bi)carbonates or glucose, has a large interest in the (bio)chemical industry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Role of Elimination of Senescent Cells in Cancer Development' to be submitted under Seventh Framework.

assistant: **Abstract**

Cellular senescence, which is a terminal cell cycle arrest, is a potent tumor suppressor mechanism that limits cancer initiation and progression; it also limits tissue damage response. While senescence is protective in the cell autonomous manner, senescent cells secrete a variety of factors that lead to inflammation, tissue destruction and promote tumorigenesis and metastasis in the sites of their presence. Here we propose a unique approach – to eliminate senescent cells from tissues in order to prevent the deleterious cell non-autonomous effects of these cells. We will use our understanding in immune surveillance of senescent cells, and in cell-intrinsic molecular pathways regulating cell viability, to identify the molecular “Achilles’ heal” of senescent cells. We will identify the mechanisms of interaction of senescent cells with NK cells and other immune cells, and harness these mechanisms for elimination of senescent cells. The impact of components of the main pathways regulating cell viability, apoptosis and autophagy, will then be evaluated for their specific contribution to the viability of senescent cells.The molecular players identified by all these approaches will be readily implemented for the elimination of senescent cells in vivo. We will consequently be able to evaluate the impact of the elimination of senescent cells on tumor progression, in mouse models, where these cells are present during initial stages of tumorigenesis. Additionally, we will develop a novel mouse model that will allow identification of senescent cells in vivo in real time. This model is particularly challenging and valuable due to absence of single molecular marker for senescent cells.The ability to eliminate senescent cells will lead to the understanding of the role of presence of se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Regulation of cell and tissue growth in drosophila'.

assistant: **Innovation**

The control of the final size of an organ and an organism is a fundamental problem in developmental biology. In the last few years, some answers have begun to emerge from Drosophila melanogaster, with the identification of some regulators of cell and tissue growth, Loss-of-function mutations, for the dmyc and cdk4 genes and for genes encoding some components of the insulin-like growth factor pathway (chico, inr, dS6K), produce small flies. In order to identify new regulators of cell and tissue growth, I propose to re-evaluate existing mutants that affect animal size. I will use genetic and genomic information and modern methods of analysis to understand the growth abnormalities in these mutants which were isolated in 30's and 50's by Bridges and Morgan, and Fahmy. A number of these mutants have been lost, suggesting that there may be many more genes to be identified. I will perform a genetic screen on the X chromosome for modifications of the size of a clonal wing compartment. The analysis of these mutants will follow this program: First, I will test if these mutations affect cell or tissue growth and cell cycle progression by clonal analysis in adult appendages and by flow cytometric (FACS) analysis. Second, genes which show interesting phenotypes will be characterized by genetic mapping, molecular cloning and rescue. Third, to confirm their role in the regulation of growth and cell proliferation, I will test if over-expression gives an opposite phenotype to loss of function. Finally, I will examine genetic interactions with pathways known to be involved in the coordination of growth and cell proliferation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Demonstration of an integrated Renovation approach for Energy Efficiency At the Multi building scale' under Horizon 2020.

assistant: **Concept**

DREEAM aims to demonstrate replicable Net Zero Energy residential building renovation approaches achieving 75% total Net Energy Demand reduction- an improvement of 60% to state of the art market practices. It will utilise packages of interconnected energy systems that achieve a balance between energy efficiency and renewable energy measures. This is enabled by enhancing renewable technologies capacity factors by using advanced building management systems with machine learning algorithms that allow building system integration and auto-optimisation across building dimensions. Currently, deep energy renovations mainly focus on building-level solutions, where, cost-effectively, an energy demand reduction of 40-50% can be achieved. In district scale projects, technologies for energy generation, storage and management can be integrated cost-effectively, reducing up to an additional 25-35% of Net Energy Demand. Multi-owner complexities and need for tailored system integration make this approach location-specific and hard to replicate. A focus on multi-building, single owner situations seeks the appropriate balance for both high energy demand reduction and high market replication potential. Energy Load Management technologies (ICT based building systems management) and services that are successfully piloted in commercial buildings will be adapted to enable this approach.The approach is a breakthrough in reaching widely applicable and replicable pathways for near-NZEB residential building renovation, in particular for social and public housing, which accounts for 12% of European stock, or 25 million units. Building owners that jointly own 160,000 dwellings, energy service engineers and finance experts collaborate to demonstrate the DREEAM approach in 3 climatologically different
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Community Based Comprehensive Recovery'.

assistant: **Objectives**

The Community Based Comprehensive Recovery (COBACORE) project aims to support common needs assessment and recovery planning efforts in complex multi-sectorial, multi-stakeholder crisis environments by building upon the community as an important source of information and capabilities. COBACORE aims to help bridge the so-called collaboration gap: failure of collaboration through insufficient information sharing among partners, incompatible work practices and misaligned decision making processes. In the field of humanitarian needs assessment, this collaboration gap is ubiquitous and detrimental to the efficiency of many recent relief efforts. Closing this gap is the key to reduce the time needed for needs assessment, better needs monitoring, and planning.The COBACORE suite of tools will support common needs assessments efforts – damage recovery needs, economic needs, health and social needs, and other critical humanitarian needs. The COBACORE assets will stimulate community-wide involvement in information gathering, sensemaking, and needs assessment practices. The COBACORE will not replace but complement existing practices and tools, and will stimulate a community-based approach to needs assessment processes.COBACORE is a set of interconnected modules and mechanisms that maintain three state models: the community model, the context model, and the needs model. The information contained in these models are accessible for users through a collaborative workspace, customized to suit their needs and preferences. The models are built up post-crisis through collected data from the affected area, through collaborative manual completion and maintenance, and through use of existing information sources, and based upon generic frames that are developed in advance for different scenario
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Polynuclear Gold Cluster Catalysis'.

assistant: **Innovation**

Gold catalysis has become an extremely attractive research field these last decades as it has been considered one of the most effective methodologies for constructing carbon-carbon or carbon-heteroatom bonds. However, the development of enantioselective catalysis mediated by gold is relatively slow, mainly due to (i) the preferred linear two-coordinated mode of AuI complexes in the activation of alkynes, thus making the π-activation substrates distant from the chiral site, and (ii) the lack of mechanism data for enantioselective gold(I)-catalyzed transformations. In this project, PGOLDCAT, we will focus on the synthesis of novel gold clusters, and silver analogues, for the catalytic activation of small molecules. The project includes the study of their catalytic performance in standard reactions and mechanism investigations by comparing the catalytic performance of gold clusters and silver analogues, together with kinetic studies and intermediates optimization by theoretical calculation. Finally, PGOLDCAT will study the application of these new architectures on developing a general asymmetric synthesis of 1,4-enynes. Overall, this research project will expand enantioselective AuI catalysis, giving insights into the gold-catalyzed mechanisms, and applying these catalysts to organic synthetic methodologies. The fellowship will also allow the experienced researcher to increase her network of contacts and follow a personalized career development plan to advance in her path towards an independent academic position.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regions4Climate' (R4C) targeting Horizon Europe.

assistant: **Abstract**

Increasingly frequent extreme weather conditions due to climate change concomitant with unsustainable historical resource use and management practices create the perfect storm - threatening our livelihoods, well-being and environment. A transition towards resilience requires that we simultaneously address social inequalities and implement cross-sectoral innovations to build social, economic and environmental resilience to extreme events. Together, Regions4Climate partners commit to addressing current and forecasted climate change-related challenges and building more resilient European communities within an innovative socially engaged, citizen-driven paradigm. We aim to develop smarter, more inclusive, more resilient regional ecosystems through cross-sectoral innovation jointly created with stakeholders, by and for people. The development and implementation of cross-sectoral strategies that incorporate combinations of social, technological, digital, business, governance and environmental solutions to common climate resilience challenges is at present constrained by knowledge deficits and uncertainties, as well as science-policy-stakeholder gaps. Regions4Climate will bridge these gaps and address existing uncertainties by further developing, adapting and integrating state-of-the-art technical know-how, innovative tools and collaborative practices to support transparent, evidence-based risk and vulnerability analyses and robust decision-making processes. We will utilise system dynamic modelling to understand relationships among and trade-offs between different resilience innovations, providing tools for informed decision-making tailored to engage stakeholders and support European regions and communities exposed to significant climate change impacts. New scientific insights
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coordination and dissemination of carbon research results in light of the implementation of kyoto protocol in europe (CARBOEUROPE)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The Kyoto Protocol and its implementation create an urgent need for estimation and accounting of carbon sinks/sources in the biosphere. CARBOEUROPE provides adult-disciplinary, fully integrated framework for the coordination of ongoing carbon research in Europe by the creation of a central structure for communication and harmonisation in order to produce and disseminate integrated products with direct implication to the post-Kyoto negotiations. By synthesizing emerging results and by set-up of a modelling task force, the current uncertainties in cutting across scales are addressed, and carbon balance estimates are verified. issues related to the implementation of the Kyoto protocol. Online and ad hoc consultation to the Commission with expert knowledge and dissemination of research results to stakeholders (industries, forestry) are key objectives of CARBOEUROPE.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Photo Stability of Ice-bound Complex Organic Molecules' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The universality of life  i.e. the likelihood that life can form in extra-terrestrial environments  hinges upon the availability of certain molecular building blocks. Whether the biomolecules of which we are made form before or after planet formation is an open question in astrochemistry; answering this question requires an understanding of the life cycle of biomolecular precursors (BPs) in various circum- and interstellar environments. Numerous complex organic molecules (COMs) with biological significance have been identified in star- and planet-forming regions through astronomical observations, motivating laboratory studies aiming to uncover the mechanisms by which prebiotic molecules are born during the early stages of planetary evolution. However, formation of BPs can only partially answer questions regarding the likelihood of life evolving elsewhere in the universe. It is also critical to understand the stability of such species in the harsh environment of the interstellar medium (ISM).Whether small BPs would have sufficient lifetimes in the ISM to eventually coalesce into larger COMs is the central question of this research proposal, which concerns the Photo-Stability of Ice-bound Complex Organic Molecules (PSI-COM). Laboratory experiments on interstellar ice analogues containing selected BPs will be performed using a fully operational and highly-specialized ultra-high vacuum apparatus. Ices will be bombarded with ultraviolet radiation characteristic of that produced in dense interstellar clouds as well as in the diffuse ISM, and the chemical evolution will be tracked to yield kinetic and mechanistic information useful to astronomical models of star and planet formation. The results will be compared with or used to steer observational studies, such as the James We
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Hybrid Ultra Flexible Printed Circuits combining flexible and low-cost printed electronics with high performance traditional silicon components.'.

assistant: **Innovation**

Printed electronics is a revolutionary, new way of manufacturing electronic components by using standard printing processes coming from the graphic arts, such as screen printing or inkjet, the difference being that it uses conducting inks. This new technique allows to print electronic components and circuits (e.g. connectors, resistors, sensors, transistors), on widely differing flexible substrates, like plastic, textiles or paper. The printed circuits and components are thin, lightweight, flexible, enabling single use/disposable devices, ubiquitous electronics and new applications, with high volume production at an economical price, compared to traditional silicon electronics. VIVAINNOVA, a company specialised in the field of printed electronics, has developed an innovative hybrid technology, the Ultra Flexible Printed Circuit (UFPC) that combines printed electronics with traditional silicon components in an ultra low cost, ultra thin and ultra flexible electronic circuit solution. Through the new UFPC technology we will transform the electronics industry by exploiting the competitive advantages of both technologies, combining the ‘high-performance and intelligent silicon-electronics’ with the ‘cost-effective and flexible printed electronics’ and to fill the technological gap between fully-printed electronics and the expansive market of the intelligent objects. The UFPC technology will develop a new generation of electronic circuits giving to the products many properties previously unthinkable like ‘smart capabilities’ combined with ‘flexibility, thinness, light-weight and robustness’, at an ‘economical price’. It will allow to reduce the manufacturing cost of smart flexible electronic circuits by up to 50% compared with the current hybrid solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PRecisIon Cancer MEdicine RepurpOsing SystEm Using Pragmatic Clinical Trials' (PRIME-ROSE), addressing dissemination and exploitation.

assistant: **Impact**

Millions of people in the EU are negatively affected by cancer, and cancer is one of the leading causes of death and morbidity in Europe (ecis.jrc.europa.eu). The PRIME-ROSE consortium will contribute to the Mission Cancer goal to optimise treatment and support quality of life of more than 3 million people by 2030.The PRIME-ROSE consortium envisions to support Mission Cancer through the following objectives: 1) increase access to optimised and affordable treatment interventions for cancer patients that prolong life and increase quality of life, 2) generate clinical evidence and evaluate effectiveness in Precision Cancer Medicine (PCM)-relevant and synthetically randomised, controlled academic investigator-initiated pragmatic clinical trials, and 3) work together across Europe with relevant experts to implement evidence-based PCM in routine practice and address inequalities in access.This consortium builds on the truly bottom-up, clinician-initiated family of DRUP-like innovative trials that provide broad access to precision medicine for cancer patients.This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment’.


**Keywords:** PCM, personalised medicine, mission cancer, treatment intervention, cancer, DRUP, clinical trial