RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Laurion Contacts combined geological and archaeological study'.

assistant: **Concept**

Through LAURICON we will show that the geological age differences between the ore deposits (“contacts”) in the Laurion mining region can be systematically investigated by laboratory analyses. In the next step, these different groups, each one deriving from a different geological “contact”, will be linked with archaeological objects made of Laurion ores (coins, by-products) with the same silver and lead isotopic fingerprint, thereby answering questions from mining archaeology and the wider field of ancient history. I, the post-doc researcher, Dr Frank Hulek, will undertake multi-disciplinary research activites and acquire advanced skills in archaeometric approaches at the NSRC “Demokritos” at Athens under the supervision of Dr Yannis Bassiakos and will carry out two secondment phases at the German Mining Museum. During a placement at the Lavrion Technological and Cultural Park, I will pass on my knowledge to a non-academic institution.The project will increase knowledge about the Laurion mineralization, that, according to recent research, had developed in more than one metallogenetic events. This will be proven by mineralogical and silver plus lead isotope analyses of ore samples from the Laurion. At the same time, these analyses will help to redefine the typical isotope ratios of Laurion ores and by that further improve the accuracy of provenance studies in this project and in archaeometallurgy in general.Based on this improved analytical data, the project will establish a chronology for the introduction of deep shaft mining techniques in the Laurion mining region, using data from Athenian silver coins as reference material. Likewise, the origin of the raw material that was used for silver production at two important workshop sites, Lambrika and Frankolimano, will be in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of Higly Eficient and Environmentally Friendly Grinding Technology Through a Minimum coolant approach' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Among metal machining processes, grinding is one of the most inefficient applications. But their finishing capabilities are not attainable by other methods. The main characteristic of grinding processes is the extremely high temperature in the contact zone, which makes necessary to use a cooling system to ensure a proper heat evacuation and to avoid piece damages. Cooling systems are based on applying a large quantity of liquid to the contact zone. Their cost, space utilisation and power consumption are the responsible of the “inefficiency” of grinding applications. The MQL (Minimum Quantity Lubrication) techniques used with a remarkable success in the cutting processes are based on a spray or mist application of cooling fluid to the cutting edge in operations like drilling, turning or milling, providing (when tools have well-defined edges). In grinding, a large number of trials have been executed in order to obtain some benefit in this extent, but the results have not been very promising, because the grinding wheel (the tool in grinding applications) is composed by an agglomeration of abrasive grains that act as micro-cutting tools in contact with the workpiece and their porosity difficult a good lubrication (some contact-grains working in dry condition, damaging tool and piece). Consortium partners have joined their efforts to develop a new approach, the MCG: Minimum Coolant for Grinding. MCG technique would provide to all cutting grains the required cooling fluid, in a minimal quantity but without loosing effectiveness. The technique is based on the use of two nozzles, not necessarily placed very close to the grinding wheel. The first nozzle will launch an oil spray which will enter through the wheel pores. The second nozzle will launch a gas that will freeze the oil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The development of novel carriers for gene therapy of tumors' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The purpose of this project is to develop novel synthetic amphiphile formulations, which express a higher delivery efficiency and cell/tissue specificity. The next step will be applying the systems as developed in a comparative study that relies upon gene expression in vitro versus in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The first AI-driven smart-learning platform that teaches not only contents but also interdisciplinary skills as the key to success' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In the era of interconnected world, we are still approaching teaching with methodologies from the industrial revolution. The result of the one-size-fits-all approach is (in EU) a 22% of underachivers in mathematics, 18% in reading and 17% in science. To maximize the potential of the future EU workforce (the students of today) we need a change of the teaching paradigm. We need to provide students with advanced tools for achieving their curricular goals but also, we need to coach them to develop their interdisciplinary competences (self-esteem, self-criticism, etc.) to unlock their true potential. Today, most schools do not have the resources (time & money) to provide individual learning and parents must support their children with private tutoring, that cost up to 1000€ per child per year. There are multitude of smart learning platforms today (Duolingo, Smartick, etc.) but they lack the capacity to develop student interdisciplinary competences. As a result, most students give up e-learning platforms after 3 weeks. Tobias and Michael, primary school teachers (IT background) have committed to change this paradigm by developing lernwolke. Lernwolke is an affordable Artificial Intelligence (AI)-driven learning platform that provides individual learning paths to each student. Our uniqueness, however, relies in the human component of our AI. Teachers and coaches, supported by the AI engine, help develop the emotional competences of each student and facilitate reaching their learning objectives and develop as a person. As there are no set goals, but the goals are adjusted to the capability of each student, lernwolke eliminates the concept of failure that is so detrimental for children. Our confidence in lernwolke relies in the 4000+ students from over 40 schools that have alrea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SINGLE NANOPARTICLE IMPACT STUDIES: THE DIRECT OBSERVATION OF ELECTROCHEMICAL BEHAVIOUR AT THE NANOSCALE' (SNISEB).

assistant: **Innovation**

The objective of this proposed work is to identify the electrochemical behaviour of nanostructured materials at the single nanoparticle level through the use of nanoparticle impact studies. The motivation for this work is the uncertainty in the literature over the origin of the altered electrochemical behaviour at the nanoscale, particularly in regards to electron transfer reactions such as electrocatalytic processes. One of the major sources of this uncertainty stems from the notoriously difficult task of preparing well-defined, homogeneously dispersed nanostructured electrodes. These difficulties hinder the identification of the altered electron transfer mechanisms, as the data is sensitive to the size, shape and structure of the nanoparticles, while their surface coverage can also provide further complications by altering the mass transport properties to the surfaces. In order to resolve these issues nano-impact studies are proposed, allowing electrochemical characterisation of individual well-defined nanoparticles and avoiding the technical limitations associated with the fabrication of large area homogeneous electrode surfaces. These results can then be rigorously analysed to identify the true nature of a wide variety of electrochemical reactions at the nanoscale. To achieve this a range of nanoparticles will be synthesised with tailored morphologies, sizes and compositions which will then be probed with a variety of surface-limited reactions, interaction with dissolved electroactive species and also the quantitative stripping of the nanoparticles. Such innovative experiments will provide key insights into the theoretical models for electron transfer at the nanoscale, aid in the future design of nanomaterials for electrocatalytic and electroanalytical applications,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FORUM: Formation and Organization of Markets in Ibero-American Cities – Regulation and Adaptation of Iberian Urban Models (15th-17th Centuries)' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project investigates the formation and regulation of spaces designated for commercial exchanges in Iberian and Ibero-American cities during the height of global trade, between the 15th and 17th centuries. It addresses a significant historiographical gap by raising an essential question: how were Iberian urban models of commercial spaces transplanted and adapted in the ""New World"", interacting with pre-existing indigenous practices and local contexts? The main hypothesis of FORUM is that these adaptations resulted in hybrid urban forms, where colonial markets functioned both as instruments of imperial power and as spaces for cultural negotiation and resistance. Structured around three key areas  commerce, urbanism, and architecture  the project emphasises the evolution of commercial spaces, such as squares and streets, which played a crucial role in the mercantile organisation of colonial cities. The interdisciplinary approach, combining documentary, cartographic and iconographic analysis with architectural and urban investigations, offers a comprehensive perspective on how these spaces shaped the daily life and structure of colonial cities. By reconstructing the process of implementing commercial spaces, FORUM reveals how market regulation was used as a tool to maintain social order and colonial hierarchies, while also allowing for adaptations to new economic and social realities. The project addresses a significant gap in the historiography of Ibero-American cities by innovatively investigating the interactions between European urban models and local realities, contributing to broader debates, both in academic and non-academic contexts, on the enduring impact of colonialism on our contemporary societies.""


**Keywords:** Urban History,  Economic History,  Comme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unravelling the Molecular Specificities of the Archaeal Core Replisome' (ArcRep) under Horizon Europe.

assistant: **Objectives**

The ability of cells to copy their genome before cell division is one of the wonders of biology. For DNA replication to succeed, multiple proteins act in concert forming a dynamic molecular engine known as the replisome. Great effort has been made to characterise all the components of the replisome, yet our understanding of how they work together to achieve DNA replication is still very limited. Recent studies have provided initial structural clues on the T7 phage, yeast and human replisomes, yet there is a large knowledge gap around the archaeal one. Furthermore, the archaeal replisome constitutes a living molecular fossil with a blend of bacterial and eukaryotic features that can help us better understand the emergence of eukaryotes.The first aim of ArcRep is to use recent advances in cryo-electron microscopy (cryo-EM) to determine the first structure of the archaeal replisome, revealing the molecular contacts that allow it to function. The second aim is to further understand how the replisome interacts with DNA, and to assess its potential for future development of tools that harness the sophistication of nature’s replisome in a test tube, as novel single-cell genomics biotechnology.With the cryo-EM experience I gained during my PhD, I will join the Sauguet lab to build up on their ample experience in the structure of archaeal replication proteins, and achieve the first aim of ArcRep. During a secondment in the Gardner lab (New England Biolabs, USA), who are experts in archaeal replication enzymology and have an established collaboration with the host lab, I will further characterise the replisome with methods previously developed in their group. This will achieve the second aim of ArcRep backed by a world leader in the production of reagents for life sciences.The di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Research for general regulators in lactococcus lactis' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The aim of this work is to search for genes involved in the regulation global responses in Lactococcus lactis. To achieve our objective, we propose to make several transcriptional fusions of promoters from cloned L. lactis genes to promoterless reporter genes (cat, lacLM, lacZ, gus, lacG) and inserted them in the lactococcal chromosome. One derivative with more than one fusion will be used to obtain a collection of insertional mutants by using a Ts-system based on an IS element (ISS1) developed in the host institution. Mutants with higher resistance to Cm or with less intense blue colour will be selected and the mutated gene will be transferred to the strains containing the other fusions in order to analyze its ability to regulate them. Further characterization of pleiotropic regulators will be made on the molecular level regarding the structure and expression of these regulatory genes and its targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New C-H activation chemistry for complex heterocycle synthesis' (CHACT).

assistant: **Concept**

The discovery of new catalytic processes is one of the pre-eminent drivers of current chemical research. The chemistry of tomorrow must be sustainable, using processes that are quicker, cheaper, cleaner and greener, and it must be innovative – new molecules are in constant demand to power the advances in medicine, materials and agriculture that structure our society. Catalytic chemistry that activates C-H bonds for synthetic manipulation speaks to both sustainability and innovation, offering near complete superiority over classic stoichiometric processes. This proposal presents new ideas for C-H activation that target heteroaromatic molecules, a fundamental class of compound having vast application in chemistry and biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Best practice in software engineering and methodologies for developing GIS applications' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The project addresses a critical problem of GIS construction, that of interactive geographic data visualisation. The ultimate aim is achieving a common understanding of the problem across the network, and adopting a common approach to its solution. Expected results are:- assessment of current practice,- identification of design requirements,- definition of a reference framework to normalise user interfaces,- issuing of recommendations to users and technology providers.ACTIONSThe work includes:- data collection by questionnaires,- data completion through interviews,- data analysis to derive requirements,- synthesis of reference frameworks,- technical feasibility studies,- validation activities by workshops and on-field experiments,- demonstrations and dissemination actions.Two target application areas are considered, Environment Control and Urban Planning. The network nodes play complementary roles, according to their mission:- GISIG, ANDIP, CNIG and Provincia di Bologna are users or user representatives;- ANDIP, CNIG, Geomatics, Tecnopolis and SATA are consultants or application developers;- IIS, Intergraph and Tecnopolis are technology providers;- Girona University, CNR-IMA, CNR-CIOC and Nexpri are research institutions.The network audience is extremely wide for the relations that all network nodes (partners and subcontractors) maintain for their institutional activities, and can be extended to all the European organisation interested in GIS user interface design and development. Result dissemination will use workshops to present, discuss, validate and revise the network understanding on the addressed problem. EXPECTED IMPACT AND EXPERIENCEThe project relevance and impact to the participants' business is strongly related to the nature of the single node:- Final users a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identifying Functional Proteins at DNA Breaks with Quantitative Proteomics in Primary Lymphocytes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

DNA double-strand breaks (DSBs) in our genome that are not repaired properly can lead to various developmental, immunological, and neurological disorders and are a major driver for genomic instability and tumorigenesis. The role of chromatin accessibility is of key importance to understand how the DNA/chromatin template senses and amplifies the DNA damage signal to properly repair the DNA in its native context. While all cells employ mechanisms for repairing DSBs, lymphocytes have uniquely adapted the same repair pathways for generating antibody diversity. During an immune response, B-lymphocytes undergo physiological DNA damage initiated by the activated-induced cytidine deaminase (AID) in a DNA rearrangement reaction called immunoglobulin heavy-chain (IgH) class-switch recombination (CSR). If AID-induced DNA breaks are not properly resolved, this B cell-specific DNA damage can lead to the formation of oncogenic chromosomal translocations; however, it is poorly understood how chromatin-associated factors coordinate this recombination reaction to suppress genomic instability. Here, I propose to use a novel approach combining chromatin immunoprecipitation and mouse genetics with state-of-the-art mass spectrometry-based label-free quantitative proteomics to identify and elucidate chromatin-bound proteins at DSBs. I will define the protein landscapes at DSBs in response to both γ-IR- and AID-induced DNA damage, based on our preliminary data, with unprecedented resolution and statistical confidence. I will perform detailed functional characterization of a subset of proteins using complementary approaches that investigate the repair of IR- and AID-induced DNA damage in lymphocytes.  These combined unbiased proteomic and focused cell-based studies will deepen our understandin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Optimisation and Demonstration Of Prefabricated Roof Integrated Pv Systems' (PERFORM), addressing dissemination and exploitation.

assistant: **Impact**

BIVP is the poorly tuned into the building process. It is therefore a time consuming and expensive activity. To remove this barrier the project PRIDE - Prefabrication of Roof Integrated PV systems was carried out under the JOULE III programme. PRIDE resulted in prefabricated PV systems for sloped residential roofs, leading to an estimated cost level of 7.3 Euro / Wp for the total roof package (including substructure) for small scale project, giving a BIPV cost reduction of more than 10%. The objective of Perform is to optimise and demonstrate Pride, a prefabricated PV concept developed under the JOULE Programme. More specific, the challenges of the project are demonstration of: The low cost; European conformity vs. National fine-tuning; The high quality; The high exploitation potential by: a. Acceptance of the PRIDE concept as a building product; b. Integration of the PRIDE concept in the building process.