RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sustainable production of biologically active molecules of marine based origin' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Innovation is the most important engine of growth and jobs in knowledge-based bio-economies. The scope of BAMMBO (Biologically Active Molecules of Marine Based Origin) is ambitious. This is intentional. BAMMBO will provide innovative solutions to overcome existing bottle-necks associated with culturing marine organisms in order to sustainably produce high yields of value-added products for the pharmaceutical, cosmetic and industrial sectors. BAMMBO will screen and identify target marine organisms (e.g. bacteria, fungi, sponges, microalgae, macroalgae and yeasts) from diverse global locations for potential as sustainable producers of high–added value molecules (HVAB’s). Our project will apply analytical methods for the extraction, purification and enrichment of targeted bioactive compounds. A detailed life cycle analysis of the production pathways developed in the project will be undertaken to fully evaluate the sustainability of production of biologically active products from marine organisms. BAMMBO will exploit knowledge and technologies developed during the project and effectively manage their transfer to relevant stakeholders in industry and the research community, as well as to policy-makers. We have brought together a multidisciplinary consortium of specialist Research and SME partners representing 8 countries including partners from ICPC countries Russia and Brazil, and from EU member states at Mediterranean, Adriatic and Atlantic coasts. In adhering to the European Strategy for Marine and Maritime Research this three year project will encourage capacity-building, integration and synergies across relevant marine sectors. Innovative technologies developed in the project will be demonstrated with the involvement of industry partners, and the results will be of inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Security and decontamination of drinking water distribution systems following a deliberate contamination' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Vulnerability of drinking water distribution systems to deliberate attacks, which would have major public health, economic and psychosocial consequences, is one of the main issues of concern to regulatory agencies, and water utilities. Such a network appears very vulnerable and easy to contaminate through reservoirs, back-flow… The main objective of this proposal is to limit the impact on the population of safe water privation because of contaminated networks, and to launch an appropriate response for rapidly restoring the use of the network after a deliberate contamination. Questions that will be addressed for successful coordinated response of water utilities and regulatory agencies to contamination include: •Detection of unexpected changes in water quality which could be in relation with a deliberate contamination event, •Adaptation of known analytical methods to rapidly detect specific CBRN contaminants in water and in biofilms. •Localization of the point sources of contamination and subsequently the contaminated area allowing delimitation of the corrective actions. •Decontamination procedures (efficient and realistic) of the distribution system. •Controlling the efficacy of the corrective actions by analysing the water bulk and especially the pipe walls and the deposits. •Cases studies will give the chance for the practitioners to apply on site in real conditions the selected sensors, methods, remediation technologies… It is a unique occasion to test an emergency procedure on a complicated, inaccessible, and relatively fragile system, to evaluate its feasibility at field scale, and to evaluate the difficulty to apply corrective treatments to the huge water bulk generated by the neutralisation/extraction of contaminants. The SecurEau project will therefore contribut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Self-supporting biofuel sludge pellet producing system for small and medium sized sewage plants' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

There is a huge number of small and medium sized sewage plants in and out of the European Union that cannot pass over urban sewage sludge for agricultural use in sufficient proportion (less than 50% in the EU), therefore the management of these sewage plants usually ask and receive permissions from environmental authorities for disposing the communal sludge in disused mines or dumps. Instead of disposal/landfilling – that regularly causes pollution of natural water resources – it would be more beneficial to produce sludge pellets. Such experiences drove us to create the InnoPellet technology, a self-supporting biofuel pellet producing system for treating communal sewage sludge that is economical in case of small scale production too. Five years of research and development led to the successful completion of a prototype machine that received regulatory approval and third-party testing/validation. After finalising the InnoPellet technology, our primary goal is to commercialise the units and relating pelleting services to wastewater companies primarily in Europe and later on the world market as well.The InnoPellet system offers an economical solution of sewage sludge treatment for wastewater companies. Our technology is a self-supporting machinery for drying and pelleting sewage sludge without external need of fossil fuel or any other additional material. Our technology fits into the ‘energy from waste’ policy of the European Union. It will enables wastewater plants to meet the strict EU environmental regulations and at the same time, reduce their sewage sludge treatment costs with 50-75%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular Tools for Nucleic Acid Manipulation for Biological Intervention', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

MMbio will bridge the classically separate disciplines of Chemistry and Biology by assembling leading experts from academia and non-academic partners (industry, technology transfer & science communication) to bring about systems designed to interfere therapeutically with gene expression in living cells. Expertise in nucleic acid synthesis, its molecular recognition and chemical reactivity is combined with drug delivery, cellular biology and experimental medicine. This project represents a concerted effort to make use of a basic and quantitative understanding of chemical interactions to develop and deliver oligonucleotide molecules of utility for therapy. Our chemical biology approach to this field is ambitious in its breadth and represents a unqiues opportunity to educate young scientists across sectorial and disciplinary barriers. Training will naturally encompass a wide range of skills, requiring a joint effort of chemists and biologists to introduce young researchers in a structured way to and array of research methodologies that no single research grouping could provide. The incorporation of early-stage and later stag ebiotechnology enterprises ensures that commercialisation of methodologies as well as the drug development process is covered in this ITN. We hope that MMBio will train scientists able to understand both the biological problem and the chemistry that holds the possible solution and develop original experimental approaches to stimulate European academic and commercial success in this area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced Teleworking Techniques and Tele-services for Insurance Agents and Customers' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The project will develop, quantify and verify two major evolution scenarios related to work and business. The first scenario concerns the adoption of an advanced tele-business environment for the main players in the insurance sector (insurance agents), through the introduction of teleworking techniques related to specific business processes and activities. The second scenario concerns the provision of cybermediation services, introducing value added business facilities for vendors while extending current work opportunities for insurance agents. The development process will exploit new technologies and emerging standards while a special study about the social and economic impact of the project's technological results will be performed. An extended study will be carried out to identify the socio-economic barriers for the adoption of new technology by tele-workers and customers of smaller enterprises.Scientific and technological objectives are to:.develop new and innovative techniques for dynamic work flow and process management for event driven customer transactions (i.e. the generation or maintenance of an insurance contract, the reporting of an accident, etc);.develop models for customer profiling, incorporating Consumer Right Protection principals in accordance with EU data protection legislation and introduce self-regulatory schemes for citizen to business relationships;.introduce technological innovation in remote Customer Relationship Management processes through the development of web Decision Support Systems for financial planning and service customisation;.develop models for dynamic cross selling in complementary markets and efficient handling of multiple contracted vendors (by agents) for on and off line personalised cyber-mediation (including payment facilities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of pathways controlling cell cycle and myogenic transcription in muscle cells. potential implications in strategies to stimulate muscle regeneration.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Regulation of gynogenic proliferation and differentiation by signalling pathways that Activate the transcription of muscle specific genes and the applications of the research for enhancing muscle regeneration in genetic disorders like muscular dystrophy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Green Ultra Light Weight Energy Storage System for Propulsion' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

GULWESS-PROP overall innovation project aims at designing a commercial solution of efficient on-board energy storage for electrically propelled vehicles. The main goal is to substitute on-board electrical batteries and hydrogen storage.Drage&Mate International has a patented in-situ on-demand hydrogen generation process able to increase the total gravimetric energy density of the system. This improvement allows existing vehicles to multiply by 2 or even by 7 their existing range which means a very profitable new opportunity to market.The current study will analyse how to progress to a commercial profitable product. To do that, GULWESS-PROP will validate the feasibility (technical, economic and operational) of the development and define a preliminary Business Plan.The goal is to transform the prototype solution which is currently in a TRL6 development stage to TRL9 market commercial product by the end of phase 2.Once GULWESS-PROP will be validated, a business chance will start-up to supply such technology to unmanned vehicles. In the close future similar system could be used in manned vehicles, and all kind of space vehicles. With this approach GULWESS-PROP will, at the end, lead a major impact within the decarbonised transportation goals in Europe. Although the lightweight hydrogen storage segment counts with several competitors, GULWESS-PROP has a competitive advantage over the rest of solutions related to the user experience: the final users consider that is easier to operate thanks to reactor cartridge refillable concept. Drage&Mate International is a Technology-Based high innovative company with proven track record within the hydrogen generation market; and with enough experience and ambition to turn the innovation of GULWESS-PROP into a sustainable product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Peroxisomal diseases: elucidation of the pathogenesis and evaluation of treatments by using mouse models (MMPD)'.

assistant: **Innovation**

The peroxisomal disorders represent a newly recognised group of rare, inherited metabolic diseases with diverse perturbations of lipid metabolism. Although much has been learned about the enzymatic and genetic basis of these disorders, there is little information with respect to the pathogenetic mechanisms. It is our purpose to generate and analyse mouse models mimicking these diseases (MPF-2 deficiency, Refsum disease, RCDP type 1 and 2). Specific aims are:1) to make an inventory of all metabolic changes in the different mouse models,2) to investigate the onset and progression of pathologies in the different organs in particular in the central nervous system and in the neuromuscular system3) to study the molecular mechanisms linking metabolic alterations with organ dysfunction by in vivo and in vitro approaches 4) to use these mouse models to evaluate diets and treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Solving the dynamic range problem of hearing: deciphering and harnessing cochlear mechanisms of sound intensity coding'.

assistant: **Innovation**

Our sense of hearing processes stimuli that differ in sound pressure by more than six orders of magnitude. Yet, while the presynaptic inner hair cells (IHCs) cover this wide dynamic range, each postsynaptic spiral ganglion neuron (SGN) encodes only a fraction and the intensity information is then reconstructed by the brain. This so-called “dynamic range problem” of hearing is known for decades, but how sound intensity information is decomposed into different neural pathways remains elusive.In vivo recordings report major functional SGN diversity and ensembles of such diverse neurons collectively encode intensity for a given sound frequency. Recently, a major heterogeneity of afferent SGN synapses with IHCs as well as different molecular SGN profiles have been discovered. How these relate to the diverse sound coding properties of SGNs remains to be elucidated.DynaHear sets out to close this gap by testing the hypothesis that an interplay of synaptic heterogeneity, molecularly distinct subtypes of SGNs, and efferent modulation serves the neural decomposition of sound intensity information. This is enabled by innovative approaches to cochlear structure and function, some of which we have recently established, while others will be developed in DynaHear. We will combine electrophysiology, optogenetics, molecular labelling and tracing, multiscale and multimodal imaging, with computational modeling. We will elucidate the molecular underpinnings of afferent synaptic heterogeneity, decipher mechanisms establishing such heterogeneity, and relate them to functional SGN diversity.DynaHear promises to fundamentally advance our understanding of sound intensity coding and contribute to solving the dynamic range problem of sound encoding. Moreover, the proposed work will help to better
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Study of the Endosomal Distribution of Polyplexes and Lipid Nanoparticles and their in-vitro Dissociation for  Improved Gene Delivery' (DiPoLiGene).

assistant: **Concept**

Nucleic acid-based therapies are currently booming with the advent of mRNA vaccines formulation. Hence, gene delivery systems employing polyplexes or lipid nanoparticles (LNPs) as versatile carriers have shown great promise for therapeutic applications due to the advantages in terms of tuneable properties and biocompatibility. Key to the success of these therapies is the development of efficient and controlled delivery systems capable of transporting the genetic material into target cells, releasing it intracellularly, and minimizing cytotoxicity. However, the efficient release of genetic material from its carriers within the endosomal compartments of target cells remains a critical challenge. This project will investigate the endosomal distribution and in-vitro dissociation mechanisms of polyplexes and LNPs, aiming to provide an outstanding insight on the structure/activity relation of nucleic acids careers. Employing a combination of state-of-the-art microscopy and spectroscopy techniques such as Förster Resonance Energy Transfer (FRET), live-cell imaging, and physicochemical approaches, this research will uncover vital insights into the intracellular dynamics of these gene delivery carriers for the better understanding of endosomal escape and particles dissociation. Furthermore, we will explore the relations between pH distribution of endosomes at various maturation levels and the corresponding accumulation of particles. This research contributes valuable insights into the intracellular fate of gene delivery carriers and provides strategies to overcome endosomal entrapment. Improved understanding of endosomal distribution and in-vitro dissociation mechanisms will ultimately facilitate the development of more efficient and targeted gene delivery systems for therapeut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'European network in language and speech'.

assistant: **Concept**

The problem addressed by ELSNET is the construction of multilingual integrated language and speech systems with unrestricted coverage of spoken and written language. This long term technological goal can only be achieved by joint efforts on a European scale, requiring skills covering virtually all subareas of language and speech technology and their intersections, and a broad language coverage. Multilingual integrated language and speech systems, even in restricted form, are crucial for the creation and the accessibility of the emerging European information infrastructure. Industries will need them when marketing services and products across language barriers. In the form of embedded systems, these integrated systems will serve as enabling technologies. The fact that out of 100 institutions currently constituting ELSNET, some 40 belong to private industry reflects that industry has acknowledged the importance of ELSNET's objectives and the role ELSNET plays in order to achieve them.ELSNET, as a Network of Excellence, brings together the main European research teams (both academic and industrial, with wide geographical coverage) and an increasing number of SMEs in the field of natural language and speech processing. It is in an excellent position to contribute to the common goal by means of research co-ordination, training and mobility. The size of the network requires an indirect approach to research co-ordination, based on convergence, integration and complementarity. Activities will focus on four areas: Integration of Language and Speech, Integration and Comparative Evaluation of Research Results, Relationship between Academia and Industry, and Language Coverage. Many of ELSNET-2's projected activities are continuations of successful actions undertaken under the prese