RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Peripheral Nervous System Tissue Engineering for Medical and Cosmetic Testing Applications' under Horizon 2020.

assistant: **Concept**

PLATFORMA is a commercially driven collaboration to produce novel high-content phenotypic platforms for screening cosmetics, pollutants and new therapeutics. We propose to create purpose-built, 3D modular human tissues supported by laser-printed bio-compatible scaffolds from which electro-physiological status of the cells can be monitored. Each tissue module will consist of multiple different cell types. Two main modules will be developed namely a Skin-Sensory Module and a Muscle-Motor Module. Skin-Sensory Module will be a world first; a commercially available innervated human skin tissue model. It will allow studies and testing of Peripheral Nervous System (PNS) responses to external stimuli in a physiologically-relevant context. This module itself can be used to investigate activities of both dermal and nerve cells at the same time. When a stimulus is introduced on the skin layer, responses of skin cells and activities of sensory neurons (e.g. pain & itch) can be recorded simultaneously. Muscle-Motor Module is an innovative motor neuron-skeletal muscle tissue model. It allows non-invasive recordings of neuromuscular transmission in real time. It will support studies of muscular atrophies & motor neuron diseases with genetically engineered or patient derived cells and long-term monitoring and analysis of drug effects (toxicity and efficacy) with live 3D imaging and electro-physiological recordings. Partners StratiCELL and Axol Bioscience will respectively champion the exploitation of the Skin-Sensory and Muscle-Motor modules, working with early adopter customers in cosmetic and dermatologic testing drug development. The technology is derived from FET Open project MESO-BRAIN featuring 2PP fabrication of 3D scaffolds with built-in electrodes and fast maturation protocols
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'ACTINIDE BOND properties in gas, liquid and solid state'.

assistant: **Innovation**

Understanding the electronic structure and chemical bonding properties of the early actinide (An) elements (Th-Cm) poses a great challenge and frontier in fundamental chemistry and physics. I aim to clarify the link between covalency and strength of the chemical bond of the early An elements from Th to Cm in gas, liquid and solid state materials - combining innovative high challenge experimental setups, advanced synchrotron based spectroscopy methods and state-of-the-art quantum chemical computations. In-situ structural studies of radioactive/radiotoxic gaseous and liquid An materials, combining soft and hard X-ray scattering and absorption methods (RIXS/HR-XANES) to probe An metal centres and their ligands, have not yet been performed at any synchrotron light source in the world. The RIXS and HR-XANES methods probe the occupied and unoccupied parts of the valence band with extraordinary energy resolution and, when combined for the metal and the ligand, unique information on the chemical bond can be obtained. I will gain a deep understanding of the An bond formation mechanisms and will develop spectroscopy methodologies with high potential for a breakthrough in efforts, e.g., to select ligands and An materials with specific characteristics. Ligands and materials with tailored properties are needed for separation of An elements from chemically similar lanthanides or for developing advanced pharmaceutical compounds for targeted cancer treatment. A deep insight into the An electronic structures is also essential for developing innovative spent nuclear fuel matrices and to understand actinide environmental behaviour e.g. in contaminated sites. The new spectroscopy approaches are also expected to boost the advances of quantum chemical theoretical methods. Those are most chal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A slow release insemination that doubles the success rate of the most common first line treatment of infertility.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Infertility impacts 25 million European citizens and 90 million couples globally (1 in 6 couples). Europe’s total fertility rate is among the lowest in the world, at 1.5 children per woman, a figure that is expected to decrease further to 1.2 by 2030 – making it a critical public health issue.Typically, infertility is treated with intrauterine insemination (IUI) or IVF. IUI is the most common first-line treatment as it is non-invasive and relatively cheap, but its success rate of around 7% means that IVF, a far more expensive and invasive procedure, with an overall success rate of around 30% becomes necessary. The market needs an affordable, easily accessible, non-invasive alternative that increases the success rate.EVIE 2.0 is a patent protected, fully automatic slow release insemination device that bypasses the hostile cervix to slowly release sperm into the uterus over four hours via a proprietary balloon catheter and an insemination syringe. Unlike standard Intrauterine Insemination (IUI), EVIE mimics nature by slowly and gently releasing the sperm - maximizing the opportunity for the sperm to reach the egg and increasing the prospect of fertilization - more than doubling the success rate of 7.2% to 18.7% and decreasing the average cost per pregnancy. EVIE 2.0 will transform the infertility market by providing an alternative non-invasive first-line treatment solution withincreased success rate, reducing the need for couples to resort to expensive and complex treatments. To have EVIE 2.0 fully projected at a European and global level we need a further investment of €2.5M to complete all product development, scale-up and complete a clinical study. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the fina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A circular fungi-based high-protein feed solution for aquaculture' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

By 2050 the global demand for food will have increased by as much as 70% driven by the growing population & massive exodus from poverty. Food production is not a sustainable industry even today. Rapid income growth means increasing demand for meat & fish, which puts additional pressure on the food industry. Aquaculture (fish farming) has seen one of the steepest production increases in the last decades, as the global fish catch has peaked. This growth, in turn, drives the growth of the fish feed production—its global production grew by extra 161m tons in 2016 & projected to reach 1bn tons by 2020.Farmed fish require protein-rich feed as well. The most widely used sources today of protein are fishmeal, soybeans or dried brewers’ yeast.  However, their protein content is low (~40%) & they are neither sustainable nor scalable.We have developed & patented purely biological circular process to grow filamentous fungi of various strains using residual waste streams from food, agriculture, pulp & paper as well as other industries. Our 1st result is Promyc—a sustainable & cost-effective replacement to protein from fishmeal & soybean for aquaculture feed formulations. It is rich in protein & vegan; it is produced via a fully sustainable, scalable, cost-efficient process. It is also safe—the fungal strains we use are benign & have the GRAS status of the US FDA. We are supported by major Swedish food innovation companies such as Oatly (SE) & other food producers. Our solution area is listed under 10 technologies that could combat climate change by the MIT Technology Review.Given sufficient financial capital & successful upscaling, we expect to be profitable in 2023, reaching ~€19m in revenues by 2024 & employing 62 FTEs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of a simple and reliable method for the characterisation and quality assurance of economical significant animal fibres'.

assistant: **Objectives**

In recent years, the economical importance of special animal fibres increased. This is especially true for high-quality fibres, particularly cashmere. Consequently, the demand of such high-quality animal fibres is also increasing. Textile manufactures and enterprises acting for industrial service, like importers, often have a problem with efficient quality-control of shipments of cashmere since they often do not consist of pure raw material but are blended with low-quality animal fibres, especially with lambswools. Although several attempts have been made to establish quality-assuring procedures for this problem, there does not exist a reliable method for the distinction between cashmere and wool fibres till today. However, there is a significant interest by the affected enterprises to assure the quality of their goods in order to grant a product security for the European market. Consequently, research is strongly needed in order to overcome these problems of testing and measurement for the quality assurance of the European customer. It is the object of this project to establish a simple and trusty method for the differentiation of cashmere and common wool fibres and to characterize clearly these raw materials. In order to determine a suitable procedure to establish this aim, a screening of different microscopical, other physical and chemical methods should be made. Such a procedure should be simple, not costly and safe in order to develop a quality standard for the relevant animal fibres and to develop a trading safety for the European market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Supporting EU Access to Canadian Research and Innovation Programmes' (ACCESS2CANADA) under Seventh Framework.

assistant: **Objectives**

The Access2Canada project is based on the need to solve the lack of awareness among EU researchers about the opportunities and obstacles for European researchers to access Canadian research and innovation programmes. The objective of this project is therefore to strengthen and increase EU-Canada S&T and innovation cooperation by supporting the access to these programmes for EU researchers. In order to achieve this main objective, the project intends to reach the following four goals: 1. Map Canadian R&D programmes and EU-Canada S&T agreements, and identify opportunities and obstacles for the EU research community to access Canadian research and innovation programmes; 2. Raise awareness amongst EU researchers about Canadian research and innovation programmes and encourage EU researchers to participate; 3. Assess European researcher participation in Canadian research and innovation programmes; and 4. Provide feedback to the EC and JSTCC about the opportunities and obstacles for EU researchers and present suggestions to improve the S&T cooperation. Added efforts will be made to identify and assess any opportunities provided by Canadian innovation programmes and players that might support cooperation in innovation with Europe  The results of the project will be publicly available on a (proposed common ACCESS4EU) website, and presented during information days, (online) conferences and relevant events in Europe. The expected impact of the project will be the reinforcement of the current bilateral S&T agreement between Canada and the EU, an increased participation of EU researchers in Canadian research and innovation programmes, and a better understanding of the reciprocity of research and innovation programmes on both sides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Novel tree breeding strategies'.

assistant: **Innovation**

The challenges facing forest geneticists and tree breeders include recognition of changing demands on forests for a wider range of high value forest products and sustainability of forest ecosystems under climate change. NOVELTREE is designed to enable significant genetic improvement of tree characteristics and forest products properties to satisfy the needs (quality, quantity, sustainability, vulnerability) of the forest-based sector and consumers.  NOVELTREE will: i) Provide a list of morphological and physiological traits relevant as selection criteria for pest tolerance, sustainable biomass production, wood properties for present and future use and plastic response to climate change  ii) Identify functional allelic polymorphisms for a suite of traits of interest in a post-genomics approach to improve selection efficiency and monitor genetic variation along the selection process iii) Develop high throughput phenotyping and genotyping tools. These new tools will allow earlier genetic evaluation, higher selection intensity, increased accuracy in genetic prediction and better monitoring of genetic diversity along generations iv) Develop novel/improved breeding strategies and demonstrate their efficiency in case studies. Demonstration will focus on model tree species of high economic importance in different European regions: Maritime Pine, Scots Pine, Spruce, and Poplar v) Assess the financial and environmental impacts of genetically improved trees at stand and landscape levels thanks to a multidisciplinary approach and simulation tools vi)  Provide tree breeders and forest owners with support decision tools for optimal deployment of improved genetic stocks in both prevailing and future climate, and under risk of pest and disease attacks vii) Provide training in emerging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unraveling the link between microbial biogeochemical cycles and mercury transformations in oxygen-depleted submarine groundwater discharges' (MIMOA).

assistant: **Concept**

Coastal aquifers are sensitive land-ocean transitional zones receiving nutrient-rich water due mainly to fertilizing practices that may increase microbial activity and reduce oxygen (O2) availability. The diverse microbial communities inhabiting these systems may have a crucial role in biogeochemical cycles including metal transformations such as mercury (Hg). Yet, the factors determining the microbial Hg transformations in coastal aquifers is poorly understood. The increasing depletion of O2 in coastal waters from submarine groundwater discharges (SGDs) may modify the biogeochemical processes and hence modulates the Hg speciation and its export to the sea. To shed light on this, the MIMOA project aims at defining the role of nutrient-enriched SGDs in microbial Hg cycling of coastal areas by combining microbial, chemical, and educative dimensions. This project will rely on the synergy of my background in biogeochemical cycles and anoxic environments with extensive expertise in Hg biogeochemistry and metagenomics of the host (Dr. Bravo). This will be complemented by the essential expertise in biochemistry of low O2 zones and analytic/environmental chemistry of the two secondment supervisors (Dr. Garcia-Robledo and Dr. Amouroux). By getting trained in bioinformatic analyses, gene detection and chemistry, I will explore the effects of O2 depletion from SGDs on microbial Hg transformations in an eutrophication context and transfer this knowledge to the general audience through science outreach and education assisted by Plàncton company as a placement. MIMOA outcomes will significantly contribute to global Hg budget by revealing the importance of Hg export through depleted O2 SGDs, having long-term consequences on marine food web contamination and improve awareness of genera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Arqus Research and Innovation' (2014-2020).

assistant: **Innovation**

The Arqus European University Alliance brings together seven longstanding prestigious comprehensive research-intensive universities who share extensive experience in joint projects and a similar profile as internationalized institutions with deep regional engagement.  Through this project, Arqus aims to enhance the research and innovation dimension of the Alliance’s activities and to address current global societal challenges through intensified joint research characterised by the pursuit of excellence, openness, transparency and effective engagement with society.   Based on analysis of existing strengths, prior cooperation and shared strategic research interests, the Alliance will focus on the fields of Artificial Intelligence/Digital Transformation and Green Deal/Climate Change as transversal priority areas for enhanced research collaboration, characterised by their interdisciplinarity.   The project is organised around three major challenges, all intended to foster a context to nurture sustainable strengthened collaboration. The first addresses Joint Science and Innovation, through building an Arqus research community, and designing a roadmap for transformation(al) excellence. The second centres on New Perspectives on Research, seeking to strengthen human capital through alternative approaches to assessment and recognition, and to re-thinking transfer, with special reference to the Social Sciences, Humanities and the Arts. The third, Open to Society, focusses on the culture change brought by Open and Citizen Science.   Arqus Research & Innovation aims to complement and build on efforts already underway to foster scientific cooperation within the European University consortium, and to seek synergies between the education, research and innovation dimensions of Arqus.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of the Calcium Sensing Receptor (CaSR) in health and disease, implications for translational medicine' (CaSR).

assistant: **Concept**

The identification of the extracellular calcium sensing receptor (CaSR) was a crucial step in understanding nutrient sensing in mammals. In mammalian organisms the CaSR has multiple roles: besides calcium homeostasis, it is involved in protection against osteoporosis, blood vessel calcification, prevention against colorectal cancer, is involved in metastasis of breast and prostate cancer cells to bone. The proposed ITN will perform basic and multidisciplinary investigations into the role of the CaSR and will provide experimental data for computational modelling. It will use holistic approaches of systems biology to gain knowledge on mechanisms of CaSR function.We will use intersectoral expertise in revealing the significance of CaSR signalling in cancer, and cardiovascular disease.The purpose of this ITN is to:•Educate and train Early Stage Researchers to become excellent scientists, enable them to gain a holistic view of their specific research area, prepare them for the challenges of working in a highly competitive environment, be it in Academia or in Industry.•Generate a systems biology model for CaSR-dependent signalling in order to find innovative therapeutic approaches and interventions for the natural and synthetic ligands of the CaSR.•Establish long lasting interdisciplinary and intersectoral cooperation among basic, clinical and applied researchers, working on the CaSR to strengthen the European Research Area.Being in a research environment that examines the role of one single molecule in many different tissues (e.g. kidney, intestine, blood vessels) and pathologies (cancer and vascular calcification), will increase the awareness of the young researchers for a holistic approach in understanding CaSR-related pathophysiology. Continuous comparison of the function