RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Vortex Robot for Rapid Low Cost Scanning and Improved Non-Destructive Testing of Large Concrete Structures', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Large public infrastructure facilities around the world like dams, cooling towers and bridges use cement as the main building material. Although made from a durable material many of these large assets have begun to age and are in need of periodic inspection to ensure their integrity. Current inspection routine involves setting up scaffolds that have to be moved around for personnel to reach to the whole of the surface.The VORTEXSCAN proposal seeks to develop a vortex robot that will autonomously navigate the vertical surfaces of such structures while deploying a combination of non destructive inspection techniques. Air suction through a nozzle of a specific geometry will create a vortex and initiate a force that attaches the robot to a vertical surface while its wheels move it around. Novel phased array Ground Penetrating Radar (GPR) will be one of the two NDT equipment carried by the robot. Low frequency ultrasonics will also be deployed and an innovative fusion of data from the two techniques will be performed. The fusion will diminish the drawbacks of each technique and create an accurate representation of the underlying material and its defects.VORTEXSCAN will create a system that can rapidly and economically inspect large vertical concrete structures saving huge amounts currently spent during the manual periodic inspections. The system will target EUs electrical power industry structures such nuclear reactor containment, dams and cooling towers as a large number of these infrastructure types are beginning to age; some of them having been built nearly a century ago.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantitative insight into chromatin nanoscale structure: sub-nuclear organisation of oncoprotein DEK' under Horizon 2020.

assistant: **Concept**

DEK protein is a chromatin architectural factor which has been consistently associated with tumour progression. Its expression level differs between normal and cancer cells, raising the possibility of using DEK as a tumour marker. On the other hand, super-resolution imaging revealed recently that nucleosomes can form discrete groups called ""clutches"" of various dimensions and densities. However, the quantitative analysis of the connection between proteins playing chromatin architectural role and nucleosome clutches has not been yet deciphered.Within this project, I hypothesize that there is a correlation between the organisation of DEK oncoprotein and the local chromatin structure related to the proliferation level of cells.The overall aim of the proposed work is to provide a more precise, quantitative understanding of possible connection between DEK expression level and local chromatin structures and by that to gain the additional information about DEK role in cancer. This project will take advantage of cutting-edge biophysical tool such as DNA origami, single-molecule localisation microscopy and cellular biology. Experimental design is based on the construction and application of a bi-dimentional DNA origami to calibrate and mimic subnuclear structures. The quantitative approach will rely on STochastic Optical Reconstruction Microscopy (STORM). This study will be done using normal cells with different level of proliferation and cancer cells with different level of malignancy.Finding the relation between DEK expression, connected to the proliferation level of normal and cancer cells, and the number of nucleosomes per clutch could improve the comprehension of chromatin organisation role in different levels of tumorigenesis. Quantitative insight to the number of nucleo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Gut microbiome interactions with genetic risk and immuno-metabolic pathways in depression' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Depression is a leading cause of disability worldwide, yet its pathophysiology remains poorly understood and predictive biomarkers are lacking. The gut microbiome—a key modulator of metabolic and immune functions—has emerged as an important contributor to brain function and mental health. While several studies report gut microbiome alterations in depression, most are cross-sectional, leaving uncertainty about its temporal relationship with depression onset. Moreover, it remains unknown whether the microbiome interacts with genetic predisposition to influence depression risk, or contributes to depression-related immuno-metabolic dysfunction. BIOME-GRID aims to identify gut microbiome features predictive of future depression and assess their interplay with host genetic liability and immuno-metabolic processes. This will be achieved through computational analysis of metagenomic, genetic, electronic health record, questionnaire and multiomic data from the prospective, population-based Estonian Microbiome Cohort, which uniquely enables the study of the microbiome before depression diagnosis and treatment. Time-to-event prediction modelling will be used to identify microbiome signatures linked to depression onset and assess their additive and interactive effects with genetic risk. Associations with host immuno-metabolic markers and risk factors, and depression symptom clusters will be examined. Findings will be validated in two Swedish cohorts. This fellowship will enhance expertise in metagenomic and multiomic data analysis, while fostering collaboration between Estonian and Swedish groups. Directly relevant to the Horizon Europe Health priority Tackling diseases and reducing disease burden, by providing insights into gut microbiome’s role in depression pathophysiology, BIOM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Optimisation of a Visual Implantable Prosthesis'.

assistant: **Innovation**

The aim of OPTIVIP is the optimisation of an implantable visual prosthesis based on the stimulation of the optic nerve and its demonstration within a pre-clinical study. The consortium have validated the underlying concept by realizing the first fully designed and clinically implanted visual prosthesis in the world; very low current thresholds allowing perception of stable phosphenes in large portions of the visual field and pattern recognition have been achieved. Components and processes (stimulator ASIC, connectors, system industrialization, qualification procedures) developed in the frame of OPTIVIP will be suitable for broad application fields. OPTIVIP will result in a fully developed visual prosthesis including a rehabilitation program. Expected performances are limited pattern recognition, landmarks identification and grasping using visuo-motor interaction.DESCRIPTION OF WORKMost of the components of the present optic nerve visual prosthesis will benefit from a redesign based on optimised specifications. This will mainly concern the external processor (including optimised optic nerve stimulation algorithms), the transcutaneous link, the implanted stimulator with a new connecting system, and the spiral cuff nerve electrode, as well as the overall cosmetics.Improved stimulation strategies will be investigated in the frame of modelling studies taking advantage of the existing phosphene-stimulating conditions data base.Efforts will also be devoted to the design of a specific rehabilitation protocol, to optimise the optic nerve visual prosthesis users' training.A new surgical method to implant the spiral cuff electrode intraorbitally around the optic nerve is planned.MILESTONESThe main milestones are:- Microsystems specifications (M1);- Delivery of implanted processor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multi-Sensor-Platform for Smart Building Management' (MSP), addressing dissemination and exploitation.

assistant: **Impact**

The concept of the MSP project is based on a multi-project wafer approach that enables the development of highly innovative components and sensors based on Key Enabling Technologies (KETs). The central objective of the MSP-project is the development of a technology and manufacturing platform for the 3D-integration of sophisticated components and sensors with CMOS technology being the sound foundation for cost efficient mass fabrication.The MSP project is focused on the development of essential components and sensors that are required for the realization of miniaturized smart systems capable for indoor and outdoor environmental monitoring:+ Gas sensors for detection of potentially harmful or toxic gases+ Sensors for particulate matter and ultrafine particles+ Development of metamaterial based IR sensors for presence and fire detection+ Development of optimized IR detectors based on SOI thermopiles+ Development of highly efficient photovoltaics and piezoelectrics for energy harvesting+ Development of light sensor and UV-A/B sensors.The rigorous employment of Through-Silicon-Via technology enables a highly flexible plug-and play" 3D-integration of these components and sensors to miniaturized smart systems with significantly advanced functionalities. The goal of the MSP project is the development of a smart multi-sensor platform for distributed sensor networks in Smart Building Management, which are able to communicate with smart phones.The MSP project covers the heterogeneous integration of KETs and contributes to reinforce European industrial leadership through miniaturization, performance increase and manufacturability of innovative smart systems. The MSP project is focused on emerging innovative technologies and processes for customer needs with a special emphasis on SM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Conceptual processes with and without sensorimotor experience: what is gained and what is missed?' in the context of a Seventh Framework call.

assistant: **Objectives**

Evidence of activation of sensorimotor circuits for action and perception during cognitive tasks, such as language understanding, has been used to challenge the “Cartesian” conception that mind and body are different entities to be studied as separate domains. However, the study of brain-damaged patients has shown that the integrity of sensorimotor processes is not necessary for language. Why would, then, there be activation of the sensorimotor system during language if that activation is not causally involved in the task? To explore this issue, we will investigate how motor processes relate to the language network in the brain, and what information is conveyed by motor processes in language. We will use trancranial magnetic stimulation (TMS) to assess whether motor activity is temporally subsequent and causally determined by activity of language-processing areas, or is independent of it. We will use functional magnetic resonance imaging (fMRI) to investigate activation patterns in the sensorimotor circuits of individuals with congenital deprivation of sensorimotor experience (i.e., amelics) during action-word comprehension, to define how action words are represented in the brain in the absence of sensorimotor experience. The conceptual design of this project takes advantage of the study of a special population, that has not been studied before in this field, and of modern techniques of analysis, such as fMRI and TMS. It has the potential to create a new line of research by establishing a bridge between different cognitive domains, and to impact conceptions in education and re-education by clarifying what sensorimotor experience adds to our conceptual ability and what is missed when it is lacking. Harvard University and CIMeC, University of Trento, will provide the idea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A new generation of head protection systems for fire fighting and related activitiesz with improved ergonomics and protection, lighter in weight and suitable for integration of new technologies in the fields of information systems, communic' in the context of a Fourth Framework call.

assistant: **Objectives**

Based on experience gained in Europe over the last ten years using existing fire-fighting helmets and masks, the Fire brigades has expressed the need for a new Head Protection Systems. There are in Europe two million fire fighters, each year many accidents occur with 0,5% daily accidents. The fire-fighting helmets currently on the market date from approx. 1985. Although they are individual products, both helmet and mask can be used in conjunction with each other. The main problems that have arisen are discomfort during use, difficulty in obtaining the correct individual sizes and use of the helmet in conjunction with advanced communication equipment, positioning equipment based on global positioning systems (GPS) and other peripheral equipment . Another factor requiring attention concerns the circumstances under which the product is used. These are country-specific, which means that there are many individual demands and requirements to take care of. This Head Protection System will have to be used in combination with the following equipment : - Basic peripheral equipment: all components currently available in conjunction with head protection systems and regarded by the fire brigades as indispensable basic equipment, such as respiration mask, heat-reflecting visor, safety goggles, reflective strip, helmet lamp, etc... -Optional equipment: all components that the fire brigade can use as additional aids, such as communication aids, equipment from related technologies that could be combined with head protection systems to enhance the safety of fire-fighters in the performance of their job (equipment that is not yet available like head-up displays, position detection systems, equipment for detection and sending of`information on the physical situation of the fireman, etc.).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Science Goes To School' under Horizon Europe.

assistant: **Concept**

The Mediterranean regions of Murcia and the Valencian Community share the same sea and horizon. A symbol of a collective future with great common environmental, technological, economic and social challenges. The contributions of bi-regional R+D+i are necessary to face these challenges, as well as it is necessary to ensure their continuity. Children and young people need to have a positive image of R+D+i, feel identified with it through inclusive and balanced gender referents and know the possibilities of STEAM (Science, Technology, Engineering, Arts and Mathematics) and research careers. Society also needs critical citizens without extreme positions not based on evidence that can weaken civic awareness and trust in democratic institutions.The main objective of Science Goes To School (SCIENCE GTS) is to implement a robust program of activities that brings research closer to society and vice versa. For this, it will use multiple informative formats (talks, workshops, shows, contests ...) and methodological resources (entertainment, humour, surprise ...). The topics covered will be both the great challenges posed by the Horizon Program, the Sustainable Development Goals and the European Green Deal, as well as the science of daily life. SCIENCE GTS contemplates two major actions: Researchers at Schools (RaS) and European Researchers' Night (ERN). RaS encourages the interaction of researchers and students, emphasizing the stimulation of scientific vocations, gender equality and inclusiveness. ERN makes researchers and general public interact, focusing on critical thinking, scientific culture and citizen science. A realistic awareness campaign will be used to secure the audience and a solvent assessment to measure the outreaches and impacts. The project is managed and coordin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SEAMLESS TELEMATICS ACROSS REGIONS', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

STAR* will apply previous EU project findings to commercialise streamlined administrative communications, coordination and continuity across all health care services in hospitals, other centres or the home. Paperwork will give way to telematics-based communications between, for example, professional hospital staff and social workers, with due regard for medical records standards, security and optimal use of resources. Demonstrated benefits of electronic data-sharing among such groups will include a global view of patient records and a more comprehensive efficient approach to treatment, backed by interactive referral and other procedures.Care for patients is increasingly being delivered by different specialists in different locations - acute hospitals, community hospitals, general practice surgeries or in the home. This leads to greater demands on the administration and management of patient-related information, both within the organisation and between organisations. The traditional method of transferring information about a patient was with a paper document - a referral letter, discharge letter or report - and whilst in a hospital, case notes physically followed the patient between different departments. As hospitals and other healthcare institutions have become computerised, patient data is captured in each department and the medical record is available at all times anywhere within the unitUnfortunately there is still a gap when it comes to communicating between different healthcare institutions and information still 'flows' on paper, fax or by telephone. With the increased use of specialist care and with the 'commercial' pressures to increase the flow of patients through the healthcare system, there is a clear requirement to replace the paper-based communication with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Exploiting cellular export of nuclear transcripts as HIV innovative therapy'.

assistant: **Concept**

The objective of ExCellENT-HIT is the exploitation of the cellular pathways responsible for the nuclear export of unprocessed HIV-1 transcripts, as a novel anti-HIV therapeutic strategy. Our approach is innovative, the objectives are very clear and focused, and achievable within two years. Combination therapies with drugs targeting viral proteins are the current standard of care for HIV-1 infections. However, drug resistant strains emerge, resulting in therapeutic failure. Consequently, new anti-HIV drugs are needed, which should represent novel chemical entities targeting new steps of the HIV replication cycle. Viruses need the host cellular metabolism in order to generate a progeny. By targeting cellular co-factors essential for HIV replication and whose inhibition is not harming the uninfected cells, drug resistance is less likely to occur.  Nuclear export of unspliced viral RNAs is an essential step of the HIV life cycle, regulated by the viral protein Rev. Compelling experimental evidence recently identified the cellular DEAD-box RNA helicase DDX3 as an essential cofactor for viral mRNA export. Therefore, we seek to inhibit the nuclear export of unspliced viral RNAs activity by a 'two hit strategy' targeting the cellular enzyme DDX3 and the viral protein Rev, thereby minimizing the appearance of drug resistance HIV mutants. Basic science, biotechnology and provocative chemistry, will integrate with the ultimate goal of targeting the Rev/DDX3 axis by the identification of molecular decoys that inhibit DDX3 helicase activity, Rev/DDX3 nuclear export and protein-protein interaction required for Rev/DDX3 function. The knowledge and technology generated in this project on therapeutic targeting of nuclear export, protein-protein interaction and helicase activity is likel