RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel analytic methods for precision Higgs boson physics' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

One of the current main goals in particle physics is the precise determination of Higgs boson properties, which simultaneously serves as a probe to new physics beyond the Standard Model (SM). The SM has been highly successful in describing the fundamental interactions of nature. However, the nature of the Higgs boson is not completely determined, and unsolved problems such as the origin of dark matter persist. These challenges call for precise studies of Higgs boson properties and searches for new physics, which are being conducted at the Large Hadron Collider (LHC). In this context, precise comparisons between theoretical predictions and experimental measurements in collider observables are crucial, particularly in boosted Higgs boson production associated with a vector boson or jet. These comparisons require advanced multi-loop calculations for higher-order quantum corrections in perturbative Quantum Field Theory.HINOVA will develop novel analytic techniques for multi-loop calculations, and aim to provide cutting-edge predictions for gluon-fusion Higgs boson production associated with a Z boson or jet at the LHC in the boosted region. Its primary goal is to analytically compute the missing next-to-leading order quantum electroweak corrections for these predictions. The main challenge lies in the calculation of two-loop four-point Feynman integrals involving top quarks, Higgs and gauge bosons. This challenge will be addressed using AsyInt, a novel analytic tool independently developed by the researcher. Its secondary goal is to establish a new method in AsyInt to analytically compute three-loop four-point Feynman integrals involving top quarks at high energies, which appear in next-to-next-to-leading order quantum chromodynamic (QCD) corrections for these predictions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated engineering approach validating reduced water and energy consumption in milk processing for wider food supply chain replication' (ENREMILK), addressing dissemination and exploitation.

assistant: **Impact**

EnReMilk will achieve significant water and energy savings in representative dairy case studies, mozzarella and milk powder production, across the supply chain. The dairy industry is an important food industry sector with sales of €124.3 billion and added value of €17.4 billion p.a. It is a high energy and water consumer, both overall and per unit production: up to 6.47 MWh (5.55 MWhth and 0.92 MWhel) and 60 m3 of water per tonne processed milk. 98 % of the fresh water used is of drinking water quality with 80% of energy consumed in process heating, pasteurisation, sterilisation, drying and cleaning operations.  During EnReMilk, energy savings of at least 20% and water savings of at least 30% will be achieved in case studies (3 months production), replicable in both SME and larger dairies. These savings will be validated against a consumption baseline of existing operation, being validated in model simulations and in physical trials. Emerging and novel engineering technologies will be optimised and implemented in key dairy unit operations to provide significant and simultaneous saving of water and energy, while ensuring food quality and safety. It will:  (i) identify and monitor water and energy consumption patterns of along the entire supply chain, (ii) model and simulate to evaluate savings potential of a vast array of technological scenarios, (iii) optimise selected technologies in case studies with highest water and energy saving potential, (iv) optimise resource supply and use strategies, and (v) ensure benefits for food producers and equipment manufacturers, while reconciling sustainability imperatives. It will ensure a smooth translation into practical implementation, providing an innovation-driven increase in the competitiveness of the EU dairy sector. EnReMilk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Skills for nuclear' (SKILLS4NUCLEAR), addressing dissemination and exploitation.

assistant: **Impact**

The Skills4Nuclear project aims to address workforce and skill shortages in EU nuclear fission and fusion sectors by establishing a long-term collaborative framework that integrates industry, research and training bodies. Its primary goal is to ensure the safe and efficient use of current and future nuclear technologies, including Small Modular Reactors, by fostering industry-driven workforce development and enhancing capacity-building in nuclear safety, waste management, decommissioning, radiation protection and medical applications.A key project outcome is the creation of a European Forum for Nuclear Workforce and Skills, which will monitor workforce needs, identify emerging skills gaps and continuously update training programs. This forum will serve as a central body ensuring Europe maintains skilled nuclear workforce capable of meeting future challenges. Collaboration of industry and educational institutions will ensure that training curricula are aligned with the latest technological advancements and safety standards.The project also includes the development of a Nuclear Skills Strategy, a multi-annual roadmap guiding efforts to attract, retrain, upskill and reskill professionals for the nuclear sector.  The strategy will promote a fair shift to nuclear energy, prioritizing diversity, inclusion and gender balance. A pilot action based on this strategy will be implemented in Poland.Another significant outcome is the implementation of reskilling and upskilling programs enabling workers from other industries, such as fossil fuels, to transition into nuclear roles. These programs will prepare the workforce for advanced technologies like SMRs and fusion with a strong focus on safety and innovation.The project will also develop a series of recommendations and tools aimed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Social Innovation in the Water Treatment Sector in the Amazon' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The AguaSociAL joint exchange programme aims to strengthen research cooperation and knowledge sharing between Brazil and Europe within the water related sciences. This venture will provide on-site training related to the rationale and benefits of water treatment techniques and technologies combined with social innovation approaches. AguaSociAL will seek to investigate and support community-driven development techniques and technologies for improving access to Water. This approach responds to the Europe 2020 Strategy of ‘promoting social innovation for the most vulnerable populations, with a particular emphasis on the provision of innovative education and training”, AguaSociAL will facilitate R&D activities that focus on the Amazonian Region, and will explore a range of issues, including: environmental protection; socio-economic factors and sustainable development, with a specific emphasis on water treatment and social innovations by local communities (especially vulnerable ones). Research will be undertaken to identify existing and potential water treatment, reuse, recycling and sanitation technologies that are socially accepted and community owned. Such approach should enable the linkage of scientific and traditional local knowledge, while simultaneously supporting a co-learning process towards sustainable development. To this end, a joint-thread of research/training activities will be set up for researchers from Brazil (States of Pará & Amazonas) participating to Training activities in EU and EU researchers seconded to Brazil within Case Study Workshops, with short exchanges (1 month) for senior and longer exchanges (2-3 months) for junior investigators, for a total of about 150 person months within 3 a year’s period. Scientific achievements are reached through inter-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'INtegrating Distributed data Infrastructures for Global ExplOitation' to be submitted under Horizon 2020.

assistant: **Abstract**

The INDIGO-DataCloud project (INDIGO for short) aims at developing a data/computing platform targeted at scientific communities, deployable on multiple hardware, and provisioned over hybrid (private or public) e-infrastructures. This platform will be built by leading European developers, resource providers, e-infrastructures and scientific communities in order to ensure its successful exploitation and sustainability.All members of the consortium share the common interest in developing advanced middleware to sustain the deployment of service models and user tools to tackle the challenges of the Big Data era. INDIGO will exploit the formidable know-how that was built in Europe along the past ten years of collaborations on scientific computing based on different consolidated and emerging paradigms (HPC, Grid and Cloud).Regarding Cloud computing, both the public and private sectors are already offering IaaS-type Cloud resources. However, numerous areas are of interest to scientific communities where Cloud computing uptake is currently lacking, especially at the PaaS and SaaS levels. The project therefore aims at developing tools and platforms based on open source solutions addressing scientific challenges in the Cloud computing, storage and network areas.INDIGO will allow application development and execution on Cloud and Grid based infrastructures, as well as on HPC clusters. The project will extend existing PaaS solutions, allowing public and private e-infrastructures, including those provided by EGI, EUDAT, PRACE and HelixNebula, to integrate their existing services, make them available through GEANT-compliant federated and distributed AA policies, guaranteeing transparency and trust in the provisioning of such services.INDIGO will also address the development of a flexi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Interactive semantic video search with a large thesaurus of machine-learned audio-visual concepts'.

assistant: **Innovation**

Video is vital to society and economy, playing a key role in news, cultural heritage documentaries, and surveillance and is becoming the natural form of communication for the Internet and mobile phones. Consumers and professionals alike need advanced storage and search technology for the management of large-scale video assets. This project takes on the challenge of creating a substantially enhanced semantic access to video, implemented in a search engine.<br/><br/>Video search engines result from the progress in many technologies: visual analysis; audio processing; machine learning; visualization, and interaction technology. A good measure of the overall progress is the TRECVID competition, posing increasingly hard and realistic problems with the obligation to discuss methods openly. In 2005, the best interactive video search came from the coordinating partner of this project.<br/><br/>This project will boost the performance of video search by basing it on a 10-fold enhancement of the thesaurus characterizing audio, visual or mixed-media content. In the US, a similar grand challenge has been posed. This project's approach is to let the system learn many, possibly weaker, detectors instead of modelling a few of them carefully. The combination of many detectors describing different aspects of the video content will render a much richer basis for the semantics. <br/><br/>The Consortium presents excellent expertise and resources: the machine learning is lead by Univ. of Surrey; video stream processing is lead by CERTH, Greece. The component audio event detection, is lead by INESC-ID, Portugal; visual image processing is lead by Univ. of Amsterdam; The Univ. of Florence leads the efforts in interaction, and CVC, Spain leads software consolidation. Finally, Beeld & Geluid, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Effect of bioactive compounds from novel tomato on glycaemia - short title (Bioactive compounds Impact on Glycaemia)'.

assistant: **Objectives**

Combining nutrients that act synergistically and have potential to lower postprandial glycaemia is an important dietary strategy that can reduce the risk of developing non-communicable diseases. Within a starch-based food matrix, like bread, the presence of bioactive compounds (polyphenols and carotenoids) can lower or delay starch digestion, and therefore the postprandial glycaemic response. This shows potential for development of bioactive-rich starchy foods, as an alternative to conventional high-glycaemic foods. Variations in dose, form and processing can result in bioactive-rich functional foods with different glycaemic potencies, thus further studies are needed to determine the role of polyphenols and carotenoids from tomato during digestion. The aim of this project is to determine the impact of polyphenols and carotenoids from tomato (naringenin and lycopene, respectively) on nutrient accessibility and impact on glycaemia.I will investigate the interaction of naringenin and lycopene from an organically grown tomato paste enriched with tomato skin, previously developed by the host group, with starch and starchy foods. Nutrient release from a food matrix and digestion will be measured in vitro at a micro- and macrostructural level, using a single-enzyme digestion system and the INFOGEST standardised static digestion model. To determine the effect of naringenin and lycopene on glycaemia, I will use biological samples from healthy study participants collected before and after 4-week intake of tomato enriched paste, from an ongoing dietary intervention study in the host group. The use of tomato by-products (skin) is a sustainable option to fortify foods, providing added value to scraps without post-harvest extraction of bioactive compounds. Results from this study wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Senescence therapy for cancer' (SENCAN).

assistant: **Concept**

Systemic treatment of advanced cancers is hampered by the development of drug resistance. To prevent resistance, my laboratory has in the past used functional genetic screens to discover several “synthetic lethal” drug combination therapies, which has resulted in 8 clinical trials to date, including one global phase 3 study. In this program, I propose a new approach to the treatment of cancer, which is not based on combinations of drugs, but rather on the sequential treatment with drugs. In a first treatment step, cells will not only be induced to stop dividing, but they will at the same time acquire a major new vulnerability that is subsequently targeted with a second drug that selectively kills cells having the newly acquired vulnerability. To accomplish this, we will take advantage of recent observations that the cellular senescence response is not only a property of primary cells, but can also be triggered in advanced cancers. Such senescent cells have dramatic changes in gene expression, chromatin structure and metabolism that we will exploit for their selective eradication.Using chemical compound libraries and loss-of-function genetic screens in cancer cells harboring a reporter gene that is activated selectively in senescent cells, we will search for genes and compounds that induce senescence in cancer cells. This will lead to the identification of compounds and/or signaling pathways whose inhibition induces senescence in cancer cells. We will also use chemical compound screens to find tools to selectively kill senescent cancer cells. We will use the targets and compounds identified in this program to test the in vivo efficacy of this “one-two punch” consecutive therapy approach: the first to induce senescence in cancer cells, the subsequent therapy to eradicate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cancer cell plasticity on targeted therapy' (CANPLAST).

assistant: **Concept**

Novel cancer molecular-targeted therapies allow to significantly prolong the survival of cancer patients. However, the inevitable acquisition of resistance mechanisms limits the clinical benefit of these treatments. To fully understand how resistance develops, it is crucial to better integrate tumor heterogeneity, cancer cell plasticity and microenvironment changes by applying cutting-edge single cell technologies directly on sequentially sampled biopsies from cancer patients. Additionally, to achieve deeper and longer-lasting clinical responses for cancer patients, we will need to target the rare drug-tolerant persister cancer cells. Samples collected before, during and after treatment will be used to fully describe the characteristics of the cells that are the source of genetic resistant variants that ultimately give rise to tumor relapses. By combining the establishment of patient-derived models, drug-screening of epigenetic inhibitors, transcriptomic and epigenetic characterization of persister cells we will aim to highlight their vulnerabilities. Finally, identify the driver mechanisms of genomic evolution by elucidating the link between oncogenic kinases and DNA repair pathways activity will be our innovative strategy to exploit putative susceptibilities to impeach the survival of resistant cells. The use of DNA repair substrate combined with CRISPR gene knockout will aim at confirming the value of targeting DNA repair pathways to profoundly transform the outcome of patients with metastatic cancer. Overall, by applying new technological breakthrough at the single cell level on patient biopsies, digging into the intrinsic nature of persister cells and taking advantages of DNA repair defects we will identify innovative treatment strategies to avoid the emergence of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SRM: Synchronous Reluctance Motor. Introducing a new lifting technology in the elevator market' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The market for lifting systems is nowadays dominated by gearless machines. Among them there is a type of machine based on the use of Neodymium permanent magnets. However, the raw material with which these magnets are made is subject to large fluctuations in the price because there is a very high dependence on the unique source of extraction, China. In addition, PM gearless motors are related to reliability problems due to the lack of knowledge about the lifespan of the magnets, as well as performance related to high operating temperatures (above 140ºC) and oxidation due to its iron components. The elevators market size is expected to grow from € 75,000 million (2015) to € 105,831 million by 2021, at a CAGR of 6.01% based on an increasing demand in Asia and Pacific area. Italian Top Gears SRL, is an Italian SME located in Bolzano di Albinea (Reggio Emilia) that is dedicated to design, manufacture and distribution of elevator traction machines with the state-of-the-art technologies for the worldwide market. Taking all of this into account, the company has patented a novel alternative system to the previous one, with similar outputs in speed, comfort and efficiency, but with a much more effective performance in the terrain of reliability and security. But above all, what makes highly interested this new system is up to 40% savings in motor costs. The innovation lies in the use of a synchronous reluctance electric motor (SRM) as a traction unit, following the requirement and needs of the lift industry. The main benefits obtained with SRM are: lower prices per unit, no electrical encoder needed in system, use of IoT applied to the lifts, reduced motor size, low maintenance, 50% lifespan increase, estimated energy savings of € 3239 and reduction of the carbon footprint of the