RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'STAND ALONE SYSTEM FOR PROVIDING REAL-TIME, ACCURATE, AND RELIABLE MONITORING AND WARNING OF ANY INCIDENTS AND DANGSYSTEM FOR COMPLETE MONITORING, ALERTING AND AUTOMATING OF THE RAILWAY INFRASTRUCTURE' under Horizon 2020.

assistant: **Concept**

Railway will remain in the foreseeable future one of the most vital parts of our transportation systems. It is reliable, cost efficient, have little environment impact and is relatively safe. Railway operators worldwide introduce new generations of trains improving travelling conditions and comfort for their passengers.  Far lower attention is given, however, to forgotten and even more important component of the entire system - the railway infrastructure and its track conditions resulting in incidents such as derailments causing human and materials losses. Unfortunately, current railway infrastructure is generally based on technology and solutions dating from the early 1950’s, extremely costly and requiring runs of expensive electrical cabling along tracks for several kilometres that are vulnerable to theft and vandalism. Railway infrastructure managers lack effective and multifunctional solutions that can detect broken rails, foreign objects on rails, floods, potentially leading to derailments. Furthermore, as of 2020, still more than 1 million unprotected rail crossings exist today globally posing a risk of collision for other vehicles and pedestrians. At NGRT, we have developed a solution which uses innovative method utilizing vibration detection to detect and identify anomalies on tracks. Our solution underwent field trials in Germany, Slovakia and UK demonstrating the use of vibrations analysis to detect incoming trains from the distance reaching 5 km. Based on the core technology, we are now developing an array of new applications capable of detecting derailments, obstacles on rails such as rocks, boulders, and slides, able to notify train drivers with sufficient advance time at a fraction of installation and maintenance costs of existing solutions. We will be usi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Decoding the rules of enhancer - promoter specificity throughout development' under Horizon Europe.

assistant: **Concept**

Enhancers control spatio-temporal gene expression, which is central to the diversification of cell-types and tissue differentiation. Enhancers can be located in close proximity to, or distally from, their target genes promoters, including in introns of non-cognate genes. To regulate gene expression, distal enhancers (E) must come into proximity to interact with their promoters (P) through folding/looping of the intervening DNA. How enhancers identify and regulate their specific target gene remains poorly understood and is subject of this proposal. Chromosome conformation capture based techniques such as Nuclear-Titrated (NuTi) Capture-C are powerful tools for the genome-wide investigation of enhancerpromoter proximity/interactions (EPIs) at sub-kilobase resolution. This project aims to uncover general features of EPIs by measuring and characterizing EPIs using NuTi Capture-C across many different developmental stages and tissues during Drosophila embryogenesis. I will analyze a massive Capture-C dataset already generated by host lab, capturing interactions from 16,663 genes promoters each at eight different conditions (with four replicates), thereby providing unprecedented scale and resolution. I will integrate this Capture-C resource with multiple genome-wide datasets (gene expression, histone marks and chromatin accessibility) from the host lab and others. The analysis of this comprehensive EPIs atlas will link enhancers to promoters (genome-wide), characterize features driving E-P specificity and potentially identify novel factors involved in their establishment. This new view of tissue- and developmental stage- specific EPIs will serve as a unique resource that we will share through a user-friendly web-based portal to a large community using this important model org
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Components for synchronous optical quadrature phase shift keyingtransmission' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Synchronous quadrature phase shift keying (QPSK) transmission combined with return-to-zero (RZ) coding and polarization division multiplex is an extremely attractive modulation format for metropolitan area and long haul fiber communication. Compared to standard intensity modulation the line rate is 4 times lower, the needed number of photons per bit less than half as high, the tolerance to chromatic dispersion about 8 times better, the tolerance to polarization mode dispersion about 3 times better, and the tolerance against fiber nonlinearities, in particular cross phase modulation, is excellent. Moreover, all linear optical distortions (polarization transformations, polarization mode dispersion, chromatic dispersion) can be equalized without losses in the electrical domain. Distinct advantages exist also over all other modulation formats, including duobinary, DPSK and DQPSK. So far, synchronous QPSK has not been realized because the necessary components were not available, for example lasers with linewidths in the lower kHz region. For the implementation of synchronous RZ-QPSK transmission with polarization division multiplex this project aims at the realization of all necessary components which can not be found on the market: LiNbO3 QPSK modulators in the transmitter, LiNbO3 optical 90� hybrids, InP balanced photoreceivers - reliably co-packaged with the 90� hybrids - and SiGe/CMOS integrated electronic circuits for signal conditioning in the receiver. Standard distributed-feedback (DFB) lasers are tolerable for signal and local oscillator lasers due to a novel carrier recovery concept that requires no phase-locked loop. It is implemented in the receiver by analog-to-digital conversion and subsequent CMOS signal processing. The symbol rate is 10 Gsymbols/s which amoun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Three-Dimensional Nonlinear Chiral Plasmonic Metamaterials' (3DNCPM) under Horizon 2020.

assistant: **Objectives**

The proposed project aims at a comprehensive understanding of the processes underlying the nonlinear optical responses of three-dimensional chiral plasmonic metamaterials (3DNCPM). Electromagnetic fields that interact with chiral plasmonic nanostructures result in strong chiroptical effects. Because their optical response is proportional to multiple powers of the enhanced near-field intensity, chiral metal nanostructures also constitute excellent candidates for nonlinear optical materials with new or improved properties. Utilizing advanced nanofabrication technologies, we are able to create complex three-dimensional metallic nanostructures and tailor their spectral response at will depending on the material properties, the nanostructure geometry, and its surrounding. The ability to concentrate light in sub-wavelength dimensions and to locally enhance the strength of the electromagnetic field in a tailored fashion will give us a full understanding of the physics behind the nonlinear optical mechanisms of plasmonics and chirality. Using sophisticated metamaterial designs, we aim at enhancing the nonlinear chiroptical effects and we believe that our work will provide a framework for exploiting the benefits of chiral nonlinear metasurfaces for novel applications, such as plasmonically enhanced mid-IR and THz generation, as well as nonlinear plasmonic sensing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Iraqi Cinema Beyond the Screen' to be submitted under Horizon Europe.

assistant: **Abstract**

In the beginning of the 20th century, Iraqi cities and urban environments changed and new public spheres and forms of workand leisure emerged. New neighborhoods, and institutions, cafés, and theaters changed the structure of urban life. In theprocess, modern leisure and entertainment began moving from the private realm into the public and increasingly came to beorganized on a commercial scale. One index of these changes was cinema, which arrived in Iraq in the early 20th centuryand quickly became a highly popular form of entertainment. A modern and global rather than a specifically Iraqidevelopment, the emergence of cinema in Iraq can be seen as a local inflexion of a global phenomenon. Situated at thecrossroads of Egyptian, Indian, European, and American film production, cinema in Iraqi sheds light on the transnationalqualities of early cinema in Iraq itself but also in the many areas across the globe where national cinema only emergedbelatedly. Yet, the development of the specific culture of cinema, so significant in the history of Iraq as well as in the field ofcinema studies and nonwestern cinema, has received scarce attention. My project undertakes this fresh subject,interrogating the transnational circulation of cultural products and material objects, including films and technology, andexploring how they came together at a particular historical moment with capital, performers, and people with technical skillsto establish cinema as a form of leisure in Iraq. Studying the emergence of cinema in Iraq through an approach that attendsto cinema’s material and transnational histories and contexts can enhance our understanding not just of Iraq and its manyentangled networks, connections and histories, but also of early cinema outside of the global centers of gravity. Fina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Deep LEarning on MANifolds and graphs' (LEMAN) under Horizon 2020.

assistant: **Objectives**

The aim of the project is to develop a geometrically meaningful framework that allows generalizing deep learning paradigms to data on non-Euclidean domains. Such geometric data are becoming increasingly important in a variety of fields including computer graphics and vision, sensor networks, biomedicine, genomics, and computational social sciences. Existing methodologies for dealing with geometric data are limited, and a paradigm shift is needed to achieve quantitatively and qualitatively better results. Our project is motivated by the recent dramatic success of deep learning methods in a wide range of applications, which has literally shaken the academic and industrial world. Though these methods have been known for decades, the computational power of modern computers, availability of large datasets, and efficient optimization methods allowed creating and effectively training complex models that made a qualitative breakthrough. In particular, in computer vision, deep neural networks have achieved unprecedented performance on notoriously hard problems such as object recognition. However, so far research has mainly focused on developing deep learning methods for Euclidean data such as acoustic signals, images, and videos. In fields dealing with geometric data, the adoption of deep learning has been lagging behind, primarily since the non-Euclidean nature of objects dealt with makes the very definition of basic operations used in deep networks rather elusive. The ambition of the project is to develop geometric deep learning methods all the way from a mathematical model to an efficient and scalable software implementation, and apply them to some of today’s most important and challenging problems from the domains of computer graphics and vision, genomics, and social network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Protein- and lipid mediators critical for gender differences in the pathological mechanisms causative in development of chronic obstructive pulmonary disease' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Chronic Obstructive Pulmonary Disease (COPD) is a global health problem of pandemic proportion, and a leading cause of morbidity and mortality worldwide. New evidence that exposure to air pollutants increases the risk of developing the disease is shifting the perception of COPD as solely a smoker's disease towards being a general health concern in urban areas. In addition, epidemiological studies indicate significant gender differences in susceptibility, with post-menopausal women being at greatest risk.COPD is primarily an inflammatory disease of the peripheral airways. In contrast to other chronic airway inflammatory diseases, e.g. asthma, treatment with inflammatory cascade inhibitors are largely ineffective in COPD. No efficacious treatments currently exist to prevent the inflammatory progression of COPD, which invariably leads to impaired lung function and premature death. The mechanisms underlying the disease progression are not well understood, yet very few resources have been allocated to the study of COPD.The main objective of the proposed study is to identify protein mediators critical in the pathological mechanisms involved in the development of COPD. In accordance with the 1st thematic priority of FP6, proteomics and bioinformatics technology will be utilized to combat major disease: Through state-of-the-art proteomics and metabolomics methodology, alterations due to disease progression and gender will be quantified. Furthermore, use of bioinformatics applications will aid in a global understanding of the cellular mechanisms underlying COPD.The results from this project are expected to have major effects upon the field of inflammation-associated diseases and will potentially develop new diagnostic techniques for early stage lung disease, enabling clinicians
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Single Cell Technologies for SMEs' (SICTEC), addressing dissemination and exploitation.

assistant: **Impact**

This project is focused on development of technologies for separation and manipulation of single biological cells for life science research and medical applications. The research plan is built upon the results of the FP7 project PASCA (GA 257073, started 01.09.2010). The single cell manipulation technology (SCM technology) developed there is based on inkjet-like printing of single biological cells confined in free flying micro droplets. It constitutes a universal platform for single cell analysis that has been proven to have high potential for many life science applications. The objective of this project is to support the participating SMEs and companies to take up the SCM technology, to realize their own applications and to develop them into innovative products for the medical, biomedical and pharmaceutical markets. Central element of the research is the SCM prototype instrument as presented in numerous publications (see www.pasca.eu). The actual project will provide validation and extension of the use of this prototype instrument and deal with necessary improvements and modifications of pre-production prototypes towards the specific needs and applications of the SME partners. In particular also topics affecting commercial exploitation like e.g. application development, design for manufacturability, reliability issues, cost and throughput optimization, extension of technical specifications, and preparation of CE IVD labeling will be investigated. Applications targeted by the individual SMEs are considering fast pathogen detection for clinical use by combining the SCM technology with MALDI TOF mass spectroscopy of single bacteria, instruments for single cell cancer and stem cell research, methods for monoclonal cell line development and in-vitro medical diagnostic appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'PORTABLE RECEPTION OF MULTIMEDIA INFORMATION SERVICES' (PROMIS).

assistant: **Innovation**

PROMIS is to demonstrate an FM wireless delivery system for electronic press and information services, with the terminal base consisting of standard industrial pocket receivers and portable computers. Applications for both business and the general public will include electronic broadcast distribution for press and newspapers, wireless extension of existing on-line services and regional and local broadcasting. Added-value services like automatic financial news updates, in which data broadcast systems complement traditional media, are envisaged, while broadcast applications will address specific user groups, such as tourist offices, besides the general public.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MOLECULAR STRATEGIES AGAINST VIRAL ENTRY AND GLYCAN SHIELDING' under Horizon Europe.

assistant: **Concept**

The SHIELD consortium targets two closely related steps in the viral replication cycle that are, as yet, difficult to study and to exploit for therapeutic interventions: 1) Virion glycosylation in the context of uptake, maturation and viral immunity. 2) Virion dynamics of entry into cells, where the plasticity of the involved proteins and their glycosylation status have key roles. The viruses studied in SHIELD are from the genera of flavivirus (DENV, WNV, YFV, Zika), mammarenaviruses (LASV) and henipaviruses (Hendra, Nipah). We bring a broad spectrum of methodical expertise to understand and exploit the interrelated processes of viral glycosylation and viral dynamics. Molecular simulations will enable the identification of cryptic pockets in viral proteins that form during the entry process, and the design of inhibitory ligands that bind to such pockets. Theoretical methods will be used to identify ligands for glycosylated viral proteins. This is intertwined with cryo-EM and nano-resolution optical microscopy which enable a detailed analysis of these events, their sensitivity to biological and chemical interference, and will allow a rational optimization of specificity and affinity. Novel chemical and biological entities (NCEs, NBEs) as tool compounds and potential starting points for drug development are obtained by targeted chemical synthesis, X-ray fragment screening, and nanobody library screens. Additionally, we study biological processes and the influence of interactions in systems of increasing complexity, which range from biochemical in-vitro to cellular assays and in vivo animal models. As the ‘glycan shield’ in Lassa/Hendra/Nipah plays a major role in immune evasion, we explore the immunological effects of an interference with protein glycosylation leading to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hierarchical Electroactive Hybrids exploiting Biological Motifs (BIOBRIDs)' (BIOBRIDs), addressing dissemination and exploitation.

assistant: **Impact**

We here propose a new approach to the formation of Hierarchical Electroactive Hybrids exploiting Biological Motifs, which will provide new strategies and tools for control that will define future bottom-up 3D construction of materials in the field of functional nanomaterials for nanoelectronics. Functional electroactive oligo(aniline)s, combined with guanine hydrogen-bonding units, will be combined with single-stranded DNA block copolymers in rationally designed ways, so that information encoded in the biological materials will control spatial placement and orientation, interactions and level of functionality in three dimensions within the formed complex and hierarchical superstructures.This groundbreaking approach will utilise combinations of DNA block copolymer (BCP) self-assembly, electroactivity and encoded self-assembly, and will open unexplored avenues in the priority areas of nanotechnology, nanoelectronics and advanced materials through its interdisciplinary and multidisciplinary approach. This proposed research will rely on modern synthetic protocols of organic chemistry, chemicophysical analyses of optoelectronic properties and structure-property interplay, self-assembly in the solid state, device fabrication and testing. It is expected that the outcomes of this proposed research will impact across these disciplines, and contribute knowledge to a high priority area for both society and the research community within the EU and beyond.This fellowship and project will be an important step forward in the research career of Dr. Dasgupta, who has experience and a very strong track record in the synthesis and assembly of functional molecular architectures and supramolecular aggregation. Dr. Dasgupta will therefore be enabled, through this Marie Curie fellowship, to s