RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rapid product development in a rapid virtual enterprise, ims rpd 2001' under Fifth Framework.

assistant: **Concept**

The goal of the project IMS Rapid Product Development 2001 is to accelerate product development processes for mechanical parts by providing tools and methods for rapid manufacturing of virtual, physical and hybrid parts. The project will comprise the realisation of a substantially improved process chain starting with physical or digital product models and leading to validated physical, virtual and hybrid parts in small or medium sized series. This will be realised by developing innovative CAD-based tooling software, rapid tooling technologies and formation of a Rapid Virtual Enterprise. Depending on the target industry a cost and lead time reduction up to 30% is expected.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The life cycle of extracellular vesicles in prostate cancer: from biogenesis and homing, to functional relevance'.

assistant: **Objectives**

The prostate cancer Extracellular Vesicle LifeCycle (proEVLifeCycle) network is an innovative, multidisciplinary trainingprogram focused on understanding the biology, biomarker potential and function of extracellular vesicles (EVs) to resolveunmet clinical needs of prostate cancer (PCa). It is within this realm, that we will equip early stage researchers with theknowledge, tools and a creative ethos to be independent scientists, leaders, and drivers of innovation. The lifecycle of EVs ispoorly understood and their potential as non-invasive biomarkers and therapy target/agents, a growing area of interest. Thisresearch can perfectly be integrated with the high need for novel biomarkers and therapy targets for PCa. Any relief in theburden of this disease will have major impact on the huge socio-economic problems for patients, families, caregivers andsociety.The ambitious scientific objectives are to unravel the mysteries of EV biogenesis, homing and uptake to explain how vesiclesoperate in disease processes; their heterogeneity, their molecular complexity, the biological functions they drive, their localand systemic dissemination and how these may be manipulated. Using state-of-the-art, network-wide shared modelsystems, imaging and profiling tools, and systems biology, the program will enlighten the lifecycle of EVs and identify novelEV biomarkers and PCa therapy targets to address the unmet clinical needs.Our original network of 7 academic and 3 company beneficiaries and 11 partners, provides optimal scientific training, crosssectoralawareness, entrepreneurship skills, communication in the modern age, extensive opportunities for mobility andpatient-facing experiences. We herein meet identified EU-skills gaps providing well-rounded and inventive experts primed for influent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Molecular mechanisms of neuronal restoration:  novel approaches for Parkinson's Disease'.

assistant: **Concept**

MOLPARK aims to define the basic cellular and molecular mechanisms underlying the generation, differentiation, survival and connectivity of nigrostriatal dopaminergic neurons and translate this knowledge into radically new therapeutic strategies for Parkinson's disease (PD). MOLPARK brings together two industrial partners and 6 world-renowned academic groups with a uniquely advantageous knowledge platform based on complementary state-of-the-art technologies and recent relevant discoveries in their laboratories. These include, unique approaches for stem cell renewal control based on novel insights into the function of GABA receptors and intracellular signaling components such as Bex1, novel neurotrophic factors for dopaminergic neurons such as CDNF and MANF, novel approaches to harness the power of GDNF and Wnt proteins for stimulating the growth of dopaminergic terminals  and novel ways to enhance synaptogenesis, MOLPARK’s strategy is based on four major interrelated objectives. I). Define the mechanisms of stem cell self-renewal, differentiation and integration and exploit these mechanisms to induce or boost existing self-repair processes with the aim of replenishing neurons in PD. 2). Define the mechanisms for sustaining dopaminergic neuron survival in health and disease with the aim of developing new, effective growth factor-based therapies aimed at protecting neurons in PD. 3). Define the mechanisms that promote the growth of DA nigrostriatal axons and dendrites with the aim of identifying therapeutic strategies based on restoring neural processes in PD. 4). Define the mechanisms that promote and sustain the synaptic connections of dopaminergic neurons with the aim of restoring connections in PD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Metabolic interactions in oceanic photosymbioses' in the context of a Horizon 2020 call.

assistant: **Objectives**

Symbiosis between heterotrophic hosts and microalgae (photosymbiosis) is a widespread and ecologically important phenomenon in the oceanic plankton. Symbiotic organisms like radiolarians (unicellular eukaryotes) are key players in marine biogeochemical cycles by contributing to predation and primary production. While knowledge of the diversity of symbiotic partners has improved in recent years, metabolic interactions remain poorly understood. This project will explore the metabolic basis of planktonic photosymbiosis, with radiolarians as an ecologically relevant model, to understand the functioning of the partnership and its contribution to elemental cycling in the pelagic ecosystem. An original and cutting-edge single-cell approach involving stable isotopes and high-resolution chemical imaging techniques (e.g. ToF-SIMS and nanoSIMS) will be used to visualize the elemental and isotopic composition of intact radiolarian symbioses at the subcellular level, and to quantify the assimilation and transfer of nutrients between partners in different experimental conditions. The same approach will be applied on cultured free-living symbionts to determine the degree of host control over symbiont metabolism. In order to develop a holistic view of metabolic interactions, bioinformatic analyses will identify key metabolic genes and pathways from available transcriptomes of radiolarians. The exceptional microscopy facility and expertise in isotope biogeochemistry at the host institution is unique in Europe. Given the interdisciplinary nature of the project consortium, the potential for exchanging new knowledge and skills is very high. This project pushes back the boundaries of marine biological research and represents a significant step in my personal development towards my long-term
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Analysis of the role of the lhy gene in the photoperiodic regulation of flowering time in arabidopsis thaliana' (1994-1998).

assistant: **Innovation**

Research objectives and content lhy is a gain of function mutation (due to LHY over-expression) which interferes with the regulation of flowering time in Arabidopsis thaliana. This project aims at: I. The screening and characterization of mutants where the LHY function is lost, by: - Suppressor mutagenesis: wild type phenotype will be screened for in mutagenised lhy mutants carrying a wild-type LHY transgene. Two types of mutation are expected and will be analysed: lhy null alleles and mutations of genes required for LHY function. - PCR: a T-DNA population will be screened for insertion in LHY by analysing DNA amplification products obtained with specific primers. II. The determination of the developmental stage at which LHY over-expression influences flowering time. Making a translational fusion between CaMV35S::LHY and a steroid-inducible regulator will enable the exogenous control of LHY activity in the nucleus. Training content (objective, benefit and expected impact) This research will give information on a novel flowering time gene and will provide new mutants for further investigations. I will acquire expertise in genetic and molecular methods used to study flowering in Arabidopsis, favouring future collaborations with Dr Coupland's and other European groups. Links with industry / industrial relevance (22) LHY has been patented. This work will contribute to its exploitation by increasing the understanding of its function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Stratosphere-Climate Links With Emphasis On The UTLS' (SCOUT-O3).

assistant: **Concept**

Reliable prediction of the future evolution of the ozone layer and surface UV is urgently required as a basis for informed decisions by European policy makers. The state of the ozone layer over the next decades will depend on the interplay between climate changes and the impact and evolution of ozone depleting substances such safes. The Montreal Protocol has successfully in reduced emissions and atmospheric concentrations of CFCs, which should return to their pre-ozone whole concentrations by about 2050. However, the ozone layer will most likely not return to its pre-ozone hole state and so the central question of the Montreal process - how and when will ozone and UV radiation recover as CFC concentrations fall? - Remains. Indeed, in order to provide essential advice to policy makers, the answer to that question is required within the next years. In this ambitious integrated project, the European predictive capability will be strengthened by focusing effort on main interlinked areas of research:coupled chemistry/climate models;the tropical UTLS; extra tropical ozone and water vapour;UV radiation;global modelling; and fundamental chemical and microphysical processes. Strong scientific management, built on Europe's excellent previous experience in stratospheric science, will bring together a critical mass of European experts in laboratory studies, atmospheric measurements and modelling. Twill exploit new satellite data, such as from ENVISAT, and new modelling approaches (e.g. fully-coupled chemistry-climate models; and the growing interaction with the numerical weather forecasting community), and take advantage of new and existing research facilities being developed at the national level. Valuable information for the assessment of the atmospheric impact of aviation will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'CPSwarm'.

assistant: **Concept**

Cyber-Physical Systems (CPS) find applications in a number of large-scale, safety-critical domains e.g. transportation, smart cities, etc. While the increased CPS adoption has resulted in the maturation of solutions for CPS development, a single consistent science of system integration for CPS has not yet been consolidated. Therefore CPS development remains a complex and error-prone task, often requiring a collection of separate tools.Moreover, interactions amongst CPS might lead to new behaviors and emerging properties, often with unpredictable results. Rather than being an unwanted byproduct, these interactions can become an advantage if explicitly managed since early design stages. CPSwarm tackles this challenge by proposing a new science of system integration and tools to support engineering of CPS swarms. CPSwarm tools will ease development and integration of complex herds of heterogeneous CPS that collaborate based on local policies and that exhibit a collective behavior capable of solving complex, industrial-driven, real-world problems.The project defines a complete toolchain that enables the designer to: (a) set-up collaborative autonomous CPSs; (b) test the swarm performance with respect to the design goal; and (c) massively deploy solutions towards “reconfigurable” CPS devices. Model-centric design and predictive engineering are the pillars of the project, enabling definition, composition, verification and simulation of collaborative, autonomous CPS while accounting for various dynamics, constraints and for safety, performance and cost efficiency issues. CPSwarm pushes forward CPS engineering at a larger scale, with an expected significant reduction of development time and costs. Project results will be tested in real-world use cases in 3 different domains: sw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tumor-Targeting Nanoengineered Bioorthogonal Technologies to Fight Metastatic Cancers' to be submitted under Horizon 2020.

assistant: **Abstract**

Multifunctional nanodevices have recently emerged as one of the most exciting new classes of drug delivery machineries to perform abiotic prodrug activation in living systems. However, as current designs have not yet been configured with cell targeting capabilities, their use is limited to the targeting of non-metastatic primary cancers. This proposal, termed 'NANOBOTS', aims to develop an unprecedented ‘track and treat’ nanomachine installed with navigational ability to achieve cell-specific targeting and prodrug activation capabilities to treat metastatic cancers. The strategy involves the development of Pd-functionalized and tetrazine-based nanodevices specifically designed to (1) track & tag both metastatic lesions and primary tumours by identification of cell-surface proteins overexpressed in cancer cells, and to (2) activate systemically-administered cytotoxic precursors inside or at the surface of those cells via Pd-catalyzed deprotection or click-to-release chemistry. Using a range of multidisciplinary methods and techniques including Organometallic Chemistry, Medicinal Chemistry, Supramolecular Chemistry and Nanotechnology, I will develop multifunctional nanobots that will enable –for the first time- targeted treatment of metastatic lesions. Importantly, the modular feature of the nanobots provide a solid ground for a powerful breadth of future applications, e.g. exploiting an over-expressed surface protein in a new disease class as 'navigational guide' beyond cancer. With the support of a MSCA-IF, I will have the opportunity of performing a highly-innovative research programme within a chemistry lab based in the Cancer Research UK Edinburgh Centre, a world-class institution on cancer biology and therapy, and under the mentorship of Dr Unciti-Broceta, one of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Geomorphic and Sedimentary responses to Climate Periodicity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Under the threat of ongoing global warming, predictions concerning how much temperatures will rise and precipitation will change are undergoing continual improvement, but the spatial distribution of predicted changes and their impacts on Earth-surface processes, notably erosion and sedimentation, are subject to great uncertainty. Such processes have immediate consequences for people living along alluvial or transport-limited rivers, which constitute the majority of rivers on Earth, yet their evolution in response to external forcing conditions is not well understood. In the GyroSCoPe project, I will address these knowledge gaps through an innovative approach that focuses on how periodic changes in climate affect Earth-surface processes. Specifically, because the dominant forcing frequencies have changed through time (notably at the Mid-Pleistocene Transition, MPT), and the frequency of each forcing period likely dictates how far downstream in alluvial channels impacts are felt, it should be possible to decipher the impacts of individual periodic forcings in the geologic record. To do this, I will apply novel tools to decipher erosion histories in mountainous regions, specifically at the MPT, and I will investigate alluvial fans and terraces in the context of a new numerical model developed by my group. These data will allow me to interpret the impact of a change in the dominant forcing period on hillslope erosion rates, track how this sediment propagates across landscapes through alluvial rivers, and thus provide a wealth of data that can be used to calibrate landscape-evolution and alluvial-channel models. This improved understanding of the fundamental impacts of the magnitude and frequency of periodic forcing on erosion rates and sediment transport through rivers will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GOLGITACs: Targeted Degradation of Golgi Apparatus residing Carbohydrate Processing Enzymes', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Oligosaccharides and glycoconjugates, a hugely diverse class of biomolecules, are closely associated with health and many diseases. Carbohydrate metabolism relies mainly on glycosidases and glycosyltransferases which are carbohydrate processing enzymes (CPEs) that break and create glycosidic bonds, respectively. Controlling their activities is vital for understanding pathological processes in, and developing therapeutics for glycan-related diseases. Recently, new targeted protein degradation (TPD) technologies, which disable disease-related proteins by degradation, have opened possibilities for proteins that are otherwise hard to inhibit. While TPD within the cytoplasm, cell membrane, and extracellular space can be achieved with current approaches, proteins in the Golgi apparatus can not be degraded by means of the current methods, yet it is a major cellular compartment where most CPEs reside. New TPD strategies targeting Golgi apparatus-resident proteins would be a major solution for CPE-related diseases with unmet medical needs. SWEET DEGRADATION aims to develop strategies that allow for the first time the degradation of proteins located in the Golgi apparatus, opening ways for a new therapeutic modality.The driving idea behind this proposal is that a molecule can be designed thatselect CPEs in the Golgi for targeted protein degradation. Such molecules, which I term GolgiTACs, will link a CPE to a Golgi transporter, either sortilin or cation-independent mannose-6-phosphate receptor (CI-M6PR), and shuttle CPEs to the lysosome for degradation. In aim 1, I will focus on developing the GolgiTAC technology whereas in aim 2, GolgiTACs will be exploited for targeted protein degradation of CPEs in disease models. In all, SWEET DEGRADATION will deliver a conceptually new gener
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Fingerprint of a Galactic Nucleus: A Multi-Wavelength, High-Angular Resolution, Near-Infrared Study of the Centre of the Milky Way' (GALACTICNUCLEUS) under Seventh Framework.

assistant: **Objectives**

Galactic stellar nuclei are very common in all types of galaxies and are marked by the presence of nuclear star clusters, the densest and most massive star clusters in the present-day Universe. Their formation is still an unresolved puzzle. The centre of the Milky Way contains a massive black hole and a stellar nucleus and is orders of magnitude closer than any comparable target. It is the only galactic nucleus and the most extreme astrophysical environment that we can examine on scales of milli-parsecs. It is therefore a crucial laboratory for studying galactic nuclei and their role in the context of galaxy evolution. Yet, suitable data that would allow us to examine the stellar component of the Galactic Centre exist for less than 1% of its projected area. Moreover, the well-explored regions are extraordinary, like the central parsec around the massive black hole, and therefore probably not representative for the overall environment. Fundamental questions on the stellar population, structure and assembly history of the Galactic Centre remain therefore unanswered. This project aims at addressing the open questions by obtaining accurate, high-angular resolution, multi-wavelength near-infrared photometry for an area of several 100 pc^2, a more than ten-fold increase compared to the current state of affairs. The Galactic Centre presents unique observational challenges because of a combination of high extinction and extreme stellar crowding. It is therefore not adequately covered by existing or upcoming imaging surveys. I present a project that is specifically tailored to overcome these observational challenges. In particular, I have developed a key technique to obtain the necessary sensitive, high-angular resolution images with a stable point spread function over large, cr