RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'From chromatin fibers to lamina-associated domains: what are the recognition determinants?'.

assistant: **Concept**

Lamina-associated domains (LADs) are large chromatin domains anchored to a protein meshwork coating the inner nuclear envelope, the nuclear lamina (NL). They cover 40% of the human genome and hold thousands of transcriptionally repressed genes. While some LADs can be locally detached from the NL upon gene activation, others are constitutively at the NL. This implies that LAD recognition and anchoring to the NL has to be tightly regulated to ensure acute gene expression. However, little is known about mechanisms governing LAD recognition and targeting to the NL. LADs are known to be A and T nucleotide-rich, but other sequence determinants have remained poorly characterized so far. In this project I will (1) investigate whether LAD recognition is directly linked to their high A/T content and (2) develop a novel tool to search for additional sequence determinants. First, I will insert in the mouse genome long DNA stretches of varying A/T percentages and determine whether A/T-rich sequences preferentially associate with the NL. Second, I will develop an approach to randomly scramble a LAD sequence organization. This method relies on the recombination between LoxP sites randomly inserted by local ""hopping"" of a transposable element. After determining the effects of the resulting rearrangements on NL association and expression of the surrounding genes, I will identify sequences that drive LAD formation. Besides, the cohesin complex partitions the genome into topologically associated domains and hence has a major impact in genome 3D folding. At last, I will investigate cohesin’s role in LAD formation and remodeling after recombination. Altogether, this project will result in an unprecedented characterization of LAD biology, a deeper understanding of cohesin’s role in genome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Electron volt energy resonance detector instrument' to be submitted under Fifth Framework.

assistant: **Abstract**

The objectives of the eVERDI project are to enhance the present performance of ISIS and to develop key technologies for the next generation of electron volt (eV) neutron instruments. The proposed eVERDI project will enhance the performance of the present VESUVIO spectrometer at ISIS and represents a very important step in the R&D efforts towards the instrumentation suite of the next generation neutron sources: the European Spallation Source (ESS) and the Spallation Neutron Source (SNS). The eVERDI project is based around the following deliverables: The construction of a high resolution and high count-rate forward scattering detector (FSD) bank for neutron scattering at high momentum transfer (10 Å-1-100 Å-1) and high energy transfer (1eV-20 eV). The construction of a very low angle detector (VLAD) bank (1°< 2q < 5°) with the required beam profile for neutron scattering at low momentum transfer (3 Å-1-10 Å-1) and with very high-energy transfer, w >1 eV. The development and optimisation of novel g detectors, to be employed in the VLAD bank, together with the associated high-count rate electronics and data acquisition systems, which will be required. The training of young scientists in developing experimental techniques and data analysis procedures for eV neutron scattering.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dynamic regulation of feeding behaviors in health and disease by top-down control of hypothalamic networks' (FeedHypNet) targeting Horizon 2020.

assistant: **Abstract**

Feeding behaviors represent a complex set of crucial for survival abilities required to meet upcoming nutritional demands. Eating disorders, such as anorexia nervosa, are widespread, difficult to treat and extremely dangerous, displaying the highest mortality rate of all psychiatric disorders and a very high relapse rate. Mechanisms of onset, progression and relapse of eating disorders are unknown. Feeding behaviors are regulated by hypothalamus, an evolutionary conservative brain region. While a role of neurochemically defined hypothalamic neurons in feeding has been recently studied, little is known about an adaptive regulation of hypothalamus by extrahypothalamic inputs. Further, it is not known how dynamic signaling in hypothalamus upon changing metabolic and environmental demands is organized to generate consistent adaptive behavior. The overarching goal of my proposal is to provide insight into neural mechanisms of healthy and pathological feeding behaviors. Combining optogenetics, electrophysiological recordings in transgenic behaving mice, Ca2+ imaging and fiber photometry, I will pursue 4 aims: (i) investigate role of neural circuitries that translate cognitive-related information to the lateral hypothalamus during adaptive feeding behaviors; (ii) characterize causal significance of top-down inputs from anxiety- and mood-related brain regions onto lateral hypothalamus in feeding, and study how changes in metabolic demands affect this signaling; (iii) study mechanisms and functions of fast, network oscillations-related and behavior-dependent signaling in hypothalamus; (iv) investigate how signaling in hypothalamus changes during development of anorexia nervosa symptoms and study consequences of optogenetically restored physiological signaling. This innovative an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Begomovirus diseases management for sustainable production of tomato in the Caribbean' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Begomovirus diseases transmitted by Bemisia tabaci are responsible for important economic losses in tomato crops in the Caribbean. Because of the limited resources of growers, the diversity of the agrosystems and the fragility of the ecosystems, the management strategies must be multi-component in nature and based on a thorough understanding of the pathosystems involved to ensure a sustainable development. BETOCARIB aims to study the pathosystems Bemisia-begomovirus-host plants and their epidemics to develop models in order to identify the key factors involved. Integrated pest management strategies able to reduce the impact of the diseases on tomato crops will be developed from these models and tested in the various islands. The most effective one will be transferred to all the islands to reach a sustainable management of begomovirus disease. This will be done through a scientific and technological co-operation between three European and four developing country research teams.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Speaker Identification Integrated Project'.

assistant: **Objectives**

SIIP is a break-through Suspect Identification solution based on a novel Speaker-Identification (SID) engine fusing multiple speech analytic algorithms (e.g. voiceprints recognition, Gender/Age/Language/Accent ID, Keyword/ Taxonomy spotting and Voice cloning detection). This Fused Speaker Identification will result in significantly higher true-positive speaker identification, reduced False-Positives/Negatives while increasing reliability & confidence. SIIP analyzes rich metadata from voice samples and social media. SIIP provides judicial admissible evidence for identifying crime/terror suspects as well as for mapping/tracing the suspect terror/crime network. SIIP is crucial when individuals use Internet-based applications (e.g. VoIP or social media) to plan a crime or terrorist attack. SIIP's results can easily be shared with relevant authorities based on a sustainable SIIP Info Sharing Center (SISC) located at INTERPOL. SISC guarantees an increased reliability of the identification results through advanced technologies and through voice samples checked against a large centralized database of samples collected by INTERPOLs 190 members (based on standard operating/data privacy procedures). SIIP multiplies and increases the information sharing and cooperation in the LEA community and speeds up the use of Speaker Identification by LEAs in Europe not only for individual identification but also for authentication. SIIP runs on all speech sources (e.g. Internet, PSTN, Cellular and SATCOM) and uses the latest OSINT data mining applications to obtain and corroborate voice samples. The SIIP consortium consists of 17 partners bringing together end-users, SME’s, industrial and academic partners from a variety of fields including Speech analytics, Social Media Analytics and Integra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced materials enabling HIgh-VOlume road transport applications of lightweight structural COMPosite parts' (HIVOCOMP) targeting Seventh Framework.

assistant: **Abstract**

The rapidly growing use of high-performance composites in high-end sectors such as aerospace, show that these materials are already commercially viable as long as production volumes are limited and applications not primarily cost-driven. In order to achieve a step-change in the application of high-performance composites in larger-volume applications, HIVOCOMP focuses on achieving radical advances in two materials systems that show unique promise for cost effective, higher-volume production of high performance carbon fibre reinforced parts. These are: 1) advanced polyurethane (PU) thermoset matrix materials offering increased mechanical performance and reduced cycle times compared to epoxy, and 2) thermoplastic PP- and PA6-based self-reinforced polymer composites incorporating continuous carbon fibre reinforcements with lower process times and far higher toughness than current thermoplastic and thermoset solutions. The project will analyse and develop these matrix materials, their combination with advanced textile preforms, and optimise material properties for advanced processing technologies, joining technologies (adhesives / welding) and the incorporation and self-diagnosis (sensing) materials. The focus on breakthrough material innovations are complemented by enabling work covering material testing, chemical and micro-mechanical modelling and simulation tool development, as well as LCA, cost and recycling analysis, and prototyping of typical applications, assuring that the proposed material innovations can be successfully translated into high-impact industrial applications. The project drives the material innovations with the road vehicle sector in mind, but has clearly identified spin-off applications in other sectors. The project foresees a step-wise implementation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synergic Circular Economy across European Regions' under Horizon 2020.

assistant: **Concept**

SCREEN aims at the definition of a replicable systemic approach towards a transition to Circular Economy in EU regions within the context of the Smart Specialization Strategy, through the identification and implementation of operational synergies between R&I investments from H2020 and the European Structural and Investment Funds, thus contributing to novel future eco-innovative and horizontal business models across different value chains. The concept of the action is to develop a EU reference framework for establish operational synergies between Horizon 2020 and the European Structural and Investment Funds related to Circular Economy by:a) Sustaining the regional actors’ participation at H2020 The mechanism of the “vouchers”, already adopted in the past, will be reinforced an harmonized, in order to ensure common rules in EU regions and therefore encouraging to composition of international Consortia applying for circular economy projects related to the regional Smart Specialisation.b) Encouraging the entrepreneurial initiatives based on H2020 project’s results The participating Regions will agree about a specific rule in their Structural Funds giving an advantage for those initiatives targeted to the exploitation of the H2020 project results with a circular economy approach.c) Investigating the possibility of maximizing the H2020 investment through a “recovery”(fully or partial) of well ranked unfinanced proposals dealing with circular economyEven if there is a clear presence of several bureaucratic and operational barriers, a possible solution could  have an impressive multiplier effect on the H2020 results.The approach of the action is to leverage on growing industry sectors in EU regions to act as a driver also for the less performing ones, through a circular economy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards new antibiotics' (TNA).

assistant: **Concept**

This project will produce Cell Factories (CAS) for the clean synthesis of antibiotics (presently produced via costly and environmentally unfriendly procedures), production of templates for modification into antibiotics/beta-lactamase inhibitors and which will make possible the commercial production of broad-spectrum beta-lactamase inhibitors. The CAS will utilise modified versions of natural enzymes involved in beta-lactic biosynthesis. The work will involve implementation of five Work Packages forming an integrated program with detailed structural, bioinorganic, engineering and fermentation studies on the relevant enzymes. The project will also produce a structural database for ferrous dependent oxygenases, define rules for engineering their selectivity and develop new methodology for crystallography and mutant screening.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Maritime industry information infrastructure' (MARINFO).

assistant: **Concept**

The European maritime industry is a large industrial community which is functionally heterogeneous and locally distributed. The maritime industry's R&D co-ordination group (RDCG) has developed a R&D strategy which is formulated in a structured R&D masterplan. An essential part of this commonly agreed R&D strategy is the development and demonstration of an open, safe and efficient Maritime Industry Information Infrastructure which currently does not exist. MARINFO which will become another element of MARIS, aims at the development and provision of an infrastructure in a stepwise approach beginning with a prototype and leading to an industry wide open and self supporting system accessible to the whole of Europe's maritime industries. The MARINFO work concentrates on selected services which allow evaluation on the following levels, felt to be of most importance to the European maritime industry: - MARINFO information services make available essential data from shipyards, classifiers and maritime R&D to selected users across Europe. These information services are multimedia based and interactive by nature, extensible, securable and based on off-the-shelf technology; - MARINFO communication services are based on electronic mail but also allow experimentation with Maritime business processes and workflow management; - MARINFO security services are of particular importance since control over use and update of valuable and sensitive maritime information is extremely important to both information providers and users. Co-operative alliances between partner on a case to case basis dictate the need for a scaleable security subsystem as it will be developed and used in MARINFO; - MARINFO standardisation services are required for the efficient best practice co-operation and effective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The production, crystallisation, and structure determination and analysis of membrane proteins involved in the virulence of Pseudomonas aeruginosa' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Experimentally, membranes and their lipid and protein components, are extremely challenging to work with. They are the main interface between the biological cell contents and the exterior medium and this makes them important targets when looking at human disease in pathogenic species. However membrane proteins require innovative and specialized strategies and techniques to produce, purify, characterize, and, in the case of structural biology, to crystallize for structure determination. This project aims to shed light on one particular protein export system present in the human pathogen Pseudomonas aeruginosa while further developing the in meso crystallization method, the data collection and data processing strategies. We will perform structure-function studies on the alkaline protease system present in pseudomonal and related species. This system is one of the important virulent factors used by these pathogens to create a favourable environment for continued infection. Increasing our knowledge on this system will be important to improve the life of patients with cystic fibrosis and those affected by bacterial refractory keratitis. We aim to clone, express, purify and crystallize three membrane proteins involved in the alkaline protease expression system by exploiting the knowledge and experience that resides within the Membrane Structural and Functional Biological. Become proficient and independent in the execution of these highly specialized techniques as applied to membrane proteins. Contribute to the methodology development from in meso crystallogenesis and crystal harvesting to diffraction data collection and processing using multiple small crystals (<80 microns). Train group members in data collection and processing, and structure determination. Solve the structur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Revolutionizing the packaging industry with a patented treatment to lignin fibres', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

STRAWTOGOLD uses straw for the first commercially viable, ecological alternative to polystyrene which has considerable environmental drawbacks and negative impacts on human health. Lack of sustainable packaging solutions is particularly a challenge for companies producing fresh goods or those sensitive to shock or temperature such as consumer electronics and pharmaceuticals. Landpack has used its broad engineering expertise and its farming background to patent a process for treating straw fibers to create a plastic material with outstanding performance in terms of shock absorbance, insulation and humidity regulation. A four step heating, de-moisturizing, pressing and packaging process creates an end product which has the potential reduce the billions of tons of plastic in our environment. Our fully biodegradable products are sold just below Styrofoam’s average price at €3.2/piece with the same excellent insulation and cooling properties and shock absorption capacity. It is 9% cheaper than its alternative, occupies 60% less space for cheaper transport, disposal and storage costs and uses 95% less energy in production. Furthermore, the final product has been praised by our customers for its aesthetic appeal to enhance their branding.While STRAWTOGOLD has already proven its potential to disrupt the status quo of packaging in the e-food sector with 500 established customers, as a next step we are looking to industrialize and fully automate our current production and create a model for scaling our plants to advance the sustainability of the pharma and industrial sectors. We are currently turning 900 tons of straw into 250,000 boxes/year on our almost fully automated production line which we will optimize and upscale to produce 2 million boxes/year to replace 0.02% of the cur