RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Load-Deformation Coupling Mechanism of Helical Anchors during Constant-Pressure Torsional Penetration in Stratified Heterogeneous Soils for Offshore Wind'.

assistant: **Objectives**

Helical Anchor (HA)—steel shaft with helical plates—provides a cost-efficient solution for floating offshore wind (FLOW), a crucial element of the EU’s energy transition. FLOW costs remain high (2~4 times fixed-bottom systems), partly due to mooring foundations, which account for 20~30% of expenses. HA alleviates this through efficient installation, high capacity, and material savings.Nevertheless, applying HA in FLOW poses unprecedented challenges: the required installation loads are orders of magnitude higher than onshore applications. While adjusting the advancement ratio can ease installation, key uncertainties remain in installation mechanics, soil-anchor interaction in layered seabeds, and anchor deformation. The HELIWIND project aims to advance HA technology from TRL 3 to TRL 5 via prototyping through three objectives (R&IOs):1) to develop and validate a 3D large-deformation model for HA installation in layered soils, using dual material models and centrifuge validation; 2) to perform parametric studies on soil behavior and anchor deformation to clarify interactions between installation, soil properties, and anchor deformation; 3) to build an intelligent tool integrating geotechnical and structural constraints with physics-informed deep learning to predict installation torque and thrust, and decide the optimized anchor geometry and material.Using interdisciplinary expertise and University of Dundee resources, the project aims to deliver:a) Advances in anchor-soil interaction and open-source tools;b) Higher HA TRLs to cut FLOW costs and boost EU energy leadership;c) Societal benefits via accelerated energy transition and reduced environmental impact.The 24-month project comprises five work packages in modeling, analysis, tool development, dissemination, and manage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Slow processes in close-to-equilibrium conditions for radionuclides in water/solid systems of relevance to nuclear waste management'.

assistant: **Innovation**

Solid/liquid chemical equilibrium hypotheses (sorption, solubility, solid-solution formation) are key concepts in the assessment of nuclear waste safety. For radionuclides at trace concentrations this corresponds to constant solution concentrations, or solid/liquid distribution ratios, if environmental conditions remain constant. However, these concepts do not account for irreversible incorporation of radionuclides in the solid phases. Indeed, there is often a gradual and very slow transition from simple adsorption processes to incorporation of trace elements in the surface structure of solid phases. For certain tetravalent actinides apparent solubility equilibrium applies to only the surface without bulk phase equilibrium. This can lead to very large uncertainty in solubility values and derived thermodynamic constants. Equilibrium concepts are characterized by a dynamic state of equal forward and backward reaction rates, under conditions where phase compositions remain constant. Most of the problems arise from a lack of understanding of the dynamics of slow processes close to equilibrium, specifically in the coupling of sorption with other surface equilibrium reactions such as dissolution/precipitation, recrystallisation, isotopic exchange and with the bulk phase equilibrium. The project intends to assess the effect of surface properties on apparent solubility as well as the kinetics of incorporation of radionuclides in the structure of a solid phase, and the associated reaction mechanisms for various solids in a systematic manner, using isotope exchange under close-to-equilibrium conditions.The project results will impact strongly (1) the use/misuse of solubility data for thermodynamics; (2) the understanding of affinity/rate relations close to equilibrium; (3) the in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A diagnostic tool for endometritis in cows, based on a portable automated image recognition software'.

assistant: **Objectives**

Endometritis is a curable uterine infection that is highly prevalent in cow farms affecting approximately 30% of cows per year, with up to 70% incidence in some herds. A farm with just 1,500 cows and with a typical incidence rate of 30% has a loss of up to €146,000 a year due to the costs associated with endometritis. Current solutions are slow, expensive, require specialized personnel and have low reliability (53%). Oculyze offers Better Dairy, an automated image recognition tool leveraging a proprietary smart algorithm using a smartphone-based microscope and a sampling kit for the diagnosis of subclinical endometritis in cows. The diagnostic tool can be easily used by anyone without professional training. It does not require expensive equipment or lab testing, just a regular smartphone. Better Dairy makes laboratory testing an easy and affordable task.During the feasibility assessment, a minimum viable product will be defined, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall project, Oculyze seeks to finalize the design of the Better Dairy, upgrade the recognition software, transfer the production line to a CMO and validate the performance through pilot with 2 cattle farms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting common mechanisms of pathogenesis in diseases of sterol homeostasis associated with lysosome dysfunction; development of novel and rapidly translatable clinical therapies' (STEROLOSOME), addressing dissemination and exploitation.

assistant: **Impact**

We have recently discovered a link at the cellular level between two rare pediatric diseases, Niemann-Pick C (NPC) and Smith-Lemli-Opitz Syndrome (SLOS). NPC is a disease where cholesterol and other lipids accumulate within the lysosome. SLOS is a multimalformation disease attributed to an inborn error of cholesterol synthesis, characterised by severe birth defects and neurological decline. Our data suggests that accumulation of a sterol precursor in patient-derived SLOS cells functionally inhibits the NPC1 protein, leading to an NPC disease-like phenotype that negates the therapeutic effect of elevated dietary cholesterol in SLOS. This discovery has important implications both conceptually and clinically. Based on these exciting observations, the fellow aims to:1. Comprehensively characterise the similarities between NPC and SLOS at the cellular and whole organism level.2. Determine the mechanism by which sterol accumulation inhibits NPC1 function and elucidate their role in regulating NPC1 activity.3. Develop rapidly translatable therapies for SLOS based on currently available NPC therapies.4. Discover clinical markers for SLOS for an upcoming clinical trial of miglustat.A multidisciplinary and cross-collaborative research approach will be employed to investigate this unexplored link. The host laboratory is a world-leader in rare disease research, within a high-level research institute. Utilising her adaptability and expertise, combined with that of the host and their collaborators (academic and industrial), the fellow would make a substantial impact in this area of unmet clinical need. Collectively, rare diseases affect ~26 million people in the EU. This project meets an important and current FP7 Health thematic priority namely “Translating research for human health”
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Design and development of novel inhibitor compounds of hepatitis c ires (internal ribosome entry site ) function', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

HVC is a growing European medical problem here there is no effective long-term therapy. Mostly fatal, this infectious disease may be chronically carried by 5 million Europeans placing a huge burden on medical services and resources. Novel and effective antiviral therapies are therefore urgently needed. We use rational drug design to develop new drugs to combat HCV at a critical stage in its life cycle. Our dugs fit a specific target in the RNA structure, freezing its shape, it is no longer able to bind its native protein, and thus viral replication is inhibited. We will determine the 3D structure of the RNA target, design and make novel drugs, develop assays to measure inhibition of RNA function, and make through iterative cycles lead molecules. In collaboration withal pharmaceutical partner such drugs would be entered into a clinical evaluation programme. This research will benefit Europeans by producing novel therapies to this debilitating and often fatal disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dental anthropology at the Pleistocene-Holocene transition – insights on lifestyle and funerary behaviour from Neolithic Liguria (Italy)' (Italy).

assistant: **Concept**

The purpose of the proposed research is using dental anthropology to contribute to our understanding of lifestyle, societies, and belief systems at the Pleistocene-Holocene transition. This is a key moment of our past, during which we shifted from hunting-gathering to the production economy on which we still live. The project will mainly focus a large (150-200 individuals) Neolithic (8-4,000 BP) skeletal assemblage from Liguria (north-western coast of Italy). The research will also involve comparisons with other Neolithic, Mesolithic (10-8,000 BP), and Upper Palaeolithic (30-10,000) sites in Italy and Europe.A number advanced and classic methodologies in dental anthropology will be applied, including microCT analysis and 3D scanning, geometric morphometrics, and non-metric analysis. The resulting data about growth and development, diet, and disease, will be cross-referenced with information from the funerary rite. The research questions bioarchaeological, i.e. inherently multidisciplinary in methods and in the theoretical framework, taking advance of the body of theory of biological anthropology, human ecology, and (social) archaeology. In particular, we will investigate (1) the time of weaning in Neolithic children: was it more or less stressful than in earlier/later times? Were non-weaned children buried in living spaces with no rite? (2) how did dental external and internal structure changed with the Neolithic? Is it microadaptation or due to genetic drift? (3) how did growth and development of the dentition and the skeleton compare to modern times? (4) is the funerary rite influenced by biological parameters such as health, diet, provenience? Was there selection of the buried? Were Neolithic caves real cemeteries?The host organization, UBx, has an excellent and prod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Targeting Norovirus Receptor Interactions at Atomic Resolution' to be submitted under Seventh Framework.

assistant: **Abstract**

Norovirus infections affect more than 200 million people worldwide every year. Since these viruses are highly contagious and cause epidemic outbreaks norovirus infections constitute a massive economic burden. Currently there are neither vaccination strategies nor therapeutics to cure the infection. We have designed first prototype entry-inhibitors against norovirus infections employing a rational approach based on NMR binding studies with virus like particles (VLPs). In order to develop these prototype inhibitors into potent antivirals information is needed on the thermodynamics and kinetics of binding of entry-inhibitors to the viral coat protein VP1. Binding data will be related to binding topologies on the surface of VP1. We suggest protein NMR experiments with selectively 2H/15N/13C amino acid labeled VP1 to study the relative binding topologies of natural attachment factors and entry-inhibitors. Isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) will yield enthalpies and entropies of binding as well as kinetic data on the binding process. Thermodynamic data in combination with relative binding topologies will then deliver guides for the rational modification of the first generation inhibitors to obtain better affinities. The modified compounds will be subjected to the same set of experiments, and depending on the results the optimization process proceeds in an iterative manner until potent entry-inhibitors are identified. Since VP1 is expressed as a homodimer (P-dimer), potent inhibitor candidates will be linked to a polymeric backbone as described earlier in order to achieve better avidity. Finally, we hope to come up with a first rationally designed entry-inhibitor against norovirus infections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Precision-Adjustable Single-System Decision-Making' under Horizon Europe.

assistant: **Concept**

Much contemporary research on decision-making purports that the brain has two distinct systems which can be used: model-free or model-based. Model-free allows for fast and automatic choices, but with a higher likelihood of errors. Model-based allows for context-specific adaptability, but with greater cognitive computational costs. In contrast to the prominent accounts of model-based vs model-free decision-making, I propose that the brain has a single decision system, which can be tuned to be more or less precise by investing more or less cognitive resources. The degree of precision determines whether the system appears to be more ""model-free"" or more ""model-based"" for any given decision. If successful, this project will play a critical role in redirecting a large sub-field of important decision-making (and learning) research. If unsuccessful, this project will provide powerful evidence that the current paradigm is correct.""


**Keywords:** confidence certainty cost-benefit-tradeoff subjective-value mental-effort simulation memory attention
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synergies for Green Transformation of Inland and Coastal Shipping' (SYNERGETICS) under Horizon Europe.

assistant: **Objectives**

The extent of shipping decarbonization and reduction of air pollutant emissions remains limited, despite the rapid development of greening technologies. This is particularly valid for existing inland vessels and coastal ships.A large scale retrofit of the fleet would accelerate the greening transformation. However, there is a wide variety of ship types with different power demands and different required volume of energy carriers. Alternative fuels require more space on board and/or more frequent bunkering. The bunkering infrastructure for such fuels is scarce, and their future price levels are uncertain. Most measures are associated with considerable investments. In addition, the existing regulatory framework still does not provide an adequate support.The question arises: which retrofit solution would be the most adequate for a ship of certain dimensions, type, and operational profile?To answer this question, the project SYNERGETICS (Synergies for Green Transformation of Inland and Coastal Shipping) will:- create synergies between the leading research institutions in ship hydrodynamics and energy transition, innovation centres and shipbuilding industry, regulatory bodies, ship owners, and technology providers with the goal to provide a catalogue of retrofit solutions which will accelerate the green transformation of inland vessels and coastal ships.- demonstrate the greening capacities of retrofit by implementing hydrogen and methanol combustion in internal combustion engines on selected existing ships in real life operational conditions;- address the greening potential of hydrodynamics improvements, by demonstrating the effectiveness of the aft-ship replacement which comprises the optimized shape of the aft part of the hull, duct, propeller, and rudder design, and impl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Computational shotgun metagenomics to detail mother-to-infant vertical microbiome transmission and microbiome-pathogen interaction in Cystic Fibrosis' (COMEMIMP).

assistant: **Concept**

The crucial biological functions of the human microbiome in health are currently being investigated with metagenomic approaches that sequence whole microbial communities from in vivo samples. The involvement of the microbiome in autoimmune diseases has been proven, and the technological transition to the second generation community-wide full-genome shotgun sequencing is potentially enabling deeper, mechanistic, and functional microbiome profiles. However, the full potential of shotgun sequencing is currently unexpressed because effective methods to analyse the produced data are missing and only few partial hypothesis-driven datasets are available. The goal of CoMeMIMP is to make a multidisciplinary breakthrough in both the analysis of shotgun metagenomic data and in the understanding of (i) the role of the human microbiome during infection and (ii) the vertical sources of the microbial and probiotic diversity in the colonizing infant gut microbiome. On the methodological aspect, I already developed the fastest and most accurate taxonomic profiling methods available, and we will fully express here the potential of metagenomic data with unprecedented strain-level resolution for all domains of life, phylogenetic/phylogenomic structure mining, and statistical predictive tools. This will have a major research impact and will provide us with invaluable additional power to address the specific hypothesis that the microbiome dictates the acquisition and severity of infections from opportunistic pathogens, and to accurately track the mother-to-infant vertical transmission of transient and resilient commensal microbiomes. We will produce and analyse metagenomic longitudinal datasets including both the microbiome and pathogen isolates in patients with cystic fibrosis, and a compre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biophysical Properties of the Neuronal Cytosol and their Dynamics upon Nutrient Starvation, Aging, and in Neurodegenerative Diseases.' (NeuroFreezing) targeting Horizon 2020.

assistant: **Abstract**

The material properties of the cytosol control the biochemistry of the cell and influence all molecular interactions by regulating rates of intracellular diffusive transport. Despite this critical role, these properties remain poorly understood, and it is unclear to what extent the cytosol is homogeneous, whether there are differences between cell types, and if these properties are stable or dynamic. It has recently been discovered that yeast cells regulate their cytosolic properties in response to stress, namely glucose-starvation and aging. These stresses result in a decrease in cell volume and an increase in cytosolic crowding, inducing widespread phase separations and aggregation of polyglutamine (polyQ)-proteins. This type of polyQ-protein aggregation is the molecular hallmark of neurodegenerative diseases like Huntington's Disease (HD), and is very poorly understood. In this project, I will produce the first description of the biophysical properties of the neuronal cytosol, and I will directly test whether aged or nutrient-deprived neurons, or neurons from an HD mouse model exhibit changes in these properties. I propose that viscosity and density of mammalian cells, and in particular neuronal cells, are dynamic properties that can be actively regulated in response to environmental changes. In particular, I will test two hypotheses:   - H1: Nutrient starvation and aging induce changes to the material properties of the neuronal cytosol. - H2: A neuronal stress-response upon starvation or aging is sufficient to trigger aggregation of polyQ-proteins.  Combining state-of-the-art techniques and expertise in the fields of neurobiology, metabolism, and biophysics, my investigation of these novel and potentially paradigm shifting hypotheses could fundamentally alter our un