RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nano-engineered monolithic Optoelectronic transducers for highly sensitive and label-free biosensing' under Sixth Framework.

assistant: **Concept**

The objective of this proposal is the development of silicon based integrated optical biosensors capable of detecting single binding events as well as label free biomolecular interactions. The transducer comprises arrays of monolithic silicon optocouplers interfaced with microfluidic channels directly integrated onto silicon. The optocouplers consist of nano-engineered silicon light emitting devices optically coupled to silicon nitride optical fibres and silicon detectors.The optical fibres are specifically biofunctionalized with a variety of biological capture probes. Nanoparticles will be employed as labels for highly sensitive detection of analytes, including single binding event sensing, whereas label free detection will be targeted through patterning of the waveguide surface. Such an integrated optical device provides for the simultaneous detection of a number of biological analytes without the need of external optical components.The main project output is a monolithic silicon microphotonic biochip integrated with microfluidic channels and recognition biomolecules as well as the associated readout and control electronics assembled in a portable bioanalytical microsystem to be tested with specific panels of pituitary hormones, steroid hormones and DNA. The main milestones are the sensitive and wide dynamic range detection of analytes through the monolithic optical transducer, affordable silicon multianalyte biochips, and portable readout and control electronics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Predictive Computational Metallurgy'.

assistant: **Concept**

Why is there no “Moore’s Law” for the creation of stronger and more durable metals?  Because there is a unique complexity to mechanical properties of metals: the strength, hardening, embrittlement, fracture, and fatigue are controlled by multi-defect interactions (dislocations/solutes/precipitates/grain boundaries).  However, such multi-defect interactions are beyond the scope of analytical elasticity theory, and thus require a deeper inquiry at atomistic and quantum scales.  And observed macroscopic mechanical behaviour arises from the collective interactions among such defects over large length and time scales.  The PI will tackle the fundamental challenge of the multi-defect, multi-scale problem in metal alloys through a combined theory/simulation effort that will push forward the frontiers of computational metallurgy and yield new, quantitative, predictive models of the mechanical performance of metals alloys that will accelerate metal design.  Three specific thrusts are proposed to predict the role of solute chemistry on : (i) fundamental dislocation phenomena, and the resulting effects on plastic flow and ductility (Solute/Dislocation/Dislocation interactions); (ii) dislocation transmission/absorption and damage nucleation along boundaries (Solute/Grain-boundary/Dislocation interactions); and (iii) the propagation of cracks under monotonic and fatigue loading (Solute/Crack/Dislocation/Grain-boundary interactions).  Small-scale Quantum, Atomistic, and/or Dislocation-level simulations will be designed to probe mechanistic concepts and to validate new predictive theories and new material constitutive models.  This approach is now feasible due to new multiscale modeling techniques developed by the PI and his recent quantitative models that resolve long-standing proble
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Railway Induced Vibration Abatement Solutions' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Ground vibration, effected by rail services, is an important environmental concern, affecting European citizens nearby any rail infrastructure. Surveys show that many Europeans are subjected to annoying levels of feelable vibration and vibration-induced noise. Although solutions are available for track in tunnels, tracks at grade are a much more extensive problem even for vibration-induced noise. However, solutions for tracks at grade are lacking: for some problems currently no feasible solutions at reasonable cost are available.A group of railway operators, infrastructure managers, infrastructure and rolling stock manufacturers, and construction companies, end users of vibration mitigation technology, have gathered, to propose a major project for Railway Induced Vibration Abatement Solutions (RIVAS). They aim at providing tools and methods to reduce vibration below the threshold of annoynace and induced noise below background levels by 2013.The group includes the expertise of research organisations and universities with specialist laboratory and theoretical modelling facilities. The issues are treated in a holistic way with the focus on reducing the annoyance to lineside residents. The project examines all vibration effects and aspects of the system: vehicle, track, propagation, freight and high-speed rail services.WP1 establishes the test procedures to monitor and control the performance of vibration mitigation measures under realistic conditionsWP2 develops and evaluates mitigation measures based on reducing the excitation of vibration at the vehicle–track interface by improved maintenanceWP3 develops and evaluates mitigation measures for ballasted and slab tracksWP4 will develop and evaluate mitigation measures based on sub-grade improvement and ground barriers with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Active nanofluidics towards ionic machines' (SHADOKS), addressing dissemination and exploitation.

assistant: **Impact**

Filtering and water purification rely traditionnally on the concept of passive sieving across properly decorated nanopores. Such basic separation principle contrasts with the highly advanced membrane processes existing in Nature, which harness the full subtleties of active transport across channels. This involves advanced functions like ionic pumps, ultra-high selective channels, or voltage-gated nanopores, which all play a key role in many vital needs and neuronal functions.The Shadoks project aims at developing the concept of artificial ionic machines, based on active nanofluidic transport.  This is an experimental project targeting a fundamental proof of concept. It moreover involves a strong theoretical counterpart, essential to experimental advances and prototyping. I will investigate a wealth of strongly non-equilibrium transport phenomena occurring at the nanoscales, taking advantage of our unique know-how in building nanofluidic heterostructures, in particular made of carbon and boron-nitride. I target ionic Coulomb blockade, on/off voltage-gated nanopore, ionic pumps, dynamical osmosis. These processes allow to tune ionic fluxes against the gradients and induce out-of-equilibrium charge separation, hereby conceiving active sieving as a novel route for separation and desalination. Those new building blocks will subsequently be assembled to create advanced bio-inspired membrane functionalities. We will use ionic pumps to store and deliver charge carriers on demand, akin to the triggered electric shock of the electric eel. Furthermore we use the active nanofluidics building blocks to mimic a basic machinery of neuronal processes. I target in particular to build an artificial dendritic spine, as an ionic information transmitter. As an ultimate goal, this is a route
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multiplying In Africa European Global Navigation Initiatives Fostering Interlaced Cooperation' (MAGNIFIC).

assistant: **Innovation**

MAGNIFIC project aims to enable the development of EGNSS applications through international cooperation. MAGNIFIC proposes to demonstrate to African Stakeholders the benefits of EGNOS and Galileo in 6 market sectors: airport surface vehicle, flight trials, Oil exploitation, Natural resources, highly secured multi-modal transport and use of secured Maritime transport. These applications have been selected based on the 6 priority applications identified in the GSA Action plan on GNSS applicationsThe selection of Africa was done taking into account that the provision of SBAS over AFI has been considered by EU since the early phase of development of EGNOS. Particularly, countries from West Africa have been selected being those countries the ones with the highest growth foreseen for the next 5 years. Certainly, one of the key aspects of the proposed solution is the possibility of the consortium of simulating EGNOS signal thanks to Thales Alenia Space SPEED platform.Other key aspects from our solution to be highlighted are:• Full range of partners allowing networking among European SMEs, European Industry European Research Centres, African academia, African Air Navigation Stakeholders, African SMEs and African petrol companies• High innovation character, attracting the most important regional companies from Africa, who have committed officially to an active and in-kind participation in the project, multiplying the impact of MAGNIFIC. • Galileo SAR demonstrations and Oil exploitation demonstrations showing the added value of GALILEO early services.MAGNIFIC project will allow fostering application development through international cooperation, awareness of EGNOS and GALILEO applications outside Europe and ensuring networking among different kind of actors from Europe and Africa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated simulation and design system for civil and structural engineering' (INSIDE), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the project is develop a high-performance analysis and design tool for the civil and structural engineering industry based on recent advances in quality-assured finite-element solutions and parallel computing.These will be integrated into a domain-specific computer-aided design system which will meet the rapidly growing demands of the civil and structural-engineering sectors. Amongst these demands are: innovative construction; improved design through better modelling; iterative just-in time design; and levels of safety and economy not achievable with oversimplified models. These demands will be addressed by the speed-up of analysis and modelling through the use of HPCN. An improved quality of analysis which will be achieved by coupling HPCN with advanced finite-element techniques. The prototype system to be developed will be based on existing software, will incorporate the latest research results and will be tested on real-life problems from civil and structural engineering. The project will stimulate the use of HPCN for simulation and design in a sector in which it has previously made little impact. http://www/bauwesen.uni-dortmund.de/nmi/inside.html
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'New production technologies of complex 3D Micro-devices through multiprocess integration of ultra precision engineering techniques'.

assistant: **Objectives**

The proposed project aims at creating new high precision manufacturing technologies to respond cost-effectively and eco-friendly to the mass customization paradigm within the production of complex shape micro parts, embedded systems and miniaturized products at micro/meso-scale level (from 10 to 10.000 micron range). The main objective of Integ-micro is the research and development of new hybrid and reconfigurable multitasking machines and combined processes based on integration of different ultra high precision techniques for the generation of 3D complex shape microcomponents made from different kinds of materials. Multitasking micromachining can be best described as the ability to perform multiple machining operations in one workholding configuration. This guarantees greater accuracy, reduced handling and plant area, faster throughput and increased productivity. The availability of several machining technologies on a single machine allows important synergies between the different machining methods. For instance, combining machining by chip removal and laser micro machine will provide the capability to remove (by laser) the burr remaining from the previous chip removal operation. Alternatively, chip removal machining and laser LIGA technique can be combined in order to machine small components that could not be produced otherwise. The project will bring high added value thanks to the minimum time loss in setting new production lines for strategic products through short reconfiguration time and reduced ramp-up phase. The above goals will be reached exploiting methods of sustainable production, including downscaling of machine size (machine size reduced of 5 times at least), new process chain approaches for dramatically reduced processing times and eco-friendly processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Two-Step-Strategy towards an Orthogonal Bio-System'.

assistant: **Concept**

The integration of orthogonality is a crucial research strategy in the rational design of biological systems for novel applications. In order to produce such highly predictable orthogonal systems, we propose to employ cell-free systems of highly engineered composition generated from living cells, which are complex enough to reproduce the major synthetic capabilities of living cells - such as the synthesis of natural and artificial saccharides - but are simplified enough to come close to truly engineerable systems. We propose a  two-step-strategy: In a first step, the protein synthesis of a growing bacterial cell will be channeled solely to a limited set of system components with the help of the RNA-interferase MazF. In a second step, the cells will be homogenized and the resulting cell-free extract, already enriched in the required protein components, will be subjected to selective hydrolysis of predefined proteins, which otherwise would connect the designed system to the remaining protein background, which would make the performance of the complex system unpredictable. As a proof-of-concept, we propose to implement a preparative 12-step synthesis from cheap glucose and N-acetyl-glucosamine to a valuable antiviral-precursor, N-acetyl-neuraminic acid.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advancing European Dry Cured Ham Value Chains with Data-Driven Authentication and Global Traceability Standards' to be submitted under Horizon Europe.

assistant: **Abstract**

The EU dry-cured ham (DCH) sector faces growing challenges related to fraud, supply chain transparency, and compliance with PDO/PGI certification standards, threatening consumer trust and market competitiveness. While blockchain-based traceability is emerging, current systems rely solely on QR codes and labeling, lacking integration with chemical fingerprinting authentication to verify product authenticity at a granular level. Additionally, smaller producers struggle with resource limitations to adopt cutting-edge traceability solutions, restricting their ability to compete in premium markets.HAMTRACE addresses these gaps by developing an interoperable, privacy-preserving, and regulation-compliant traceability framework, integrating advanced analytical chemistry, AI, blockchain, and federated learning. The project will 1) Map critical control points across the value chain to enhance risk assessment. 2) Implement high-precision elemental fingerprinting to distinguish authentic DCH from fraudulent imitations. 3) Leverage AI-driven hyperspectral imaging and elemental fingerprinting to authenticate curing time and regional specificity. 4) Develop a Hyperledger Fabric blockchain system, embedding tamper-proof smart tags and real-time fraud detection using AI-enhanced anomaly detection.HAMTRACE goes beyond conventional traceability by introducing a human-in-the-loop AI model, ensuring ethical compliance and transparent decision-making. This aligns with GDPR, the EU AI Act, the Green Deal, or the Farm-to-Fork Strategy, reinforcing EU’s leadership in food safety R&I. By offering scalable, industry-ready solutions, HAMTRACE enhances consumer confidence, protects PDO/PGI certifications, and strengthens the EU DCH sector’s competitive edge globally. This groundbreaking fusion of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of a marketable adjuvant candidate for vaccine applications' (ADJUVACCINE).

assistant: **Innovation**

ADJUVACCINE seeks to leverage a breakthrough made in the ERC-2016-STG-716878 project to validate a synthetic technological platform for the scalable production of identified optimised saponin adjuvants for improved cost-effective vaccines. We have developed in the laboratory potent, safe, stable, and streamlined adjuvant leads that surpass the QS-21 natural product adjuvant, leading to patent applications and the interest of Pharma. In this PoC project, we aim to exploit our synthetic saponin technology to produce adjuvant/vaccine candidates at scale that outperform existing products more cost-effectively, lowering the risk profile of the commercialisation potential, while also achieving valorisation outcomes for market entry. The goal is to demonstrate the scalability of our innovative adjuvant technology and select an optimal adjuvant candidate in advanced preclinical settings for entering the vaccine market via spin-off formation following proper IPR strategy implementation and attraction of key investors/partners.The breakthrough innovation potential of ADJUVACCINE lies in the exploitation of this adjuvant platform for large-scale production and selection of the best candidate lead for application in vaccines against various diseases, improving the available vaccine solutions. The high purity and excellent chemical control of our synthetic technology versus the heterogeneous natural product adjuvants, as well as its streamlined, scalable nature and low-cost profile are unique attributes of our platform that will be valorised herein, making it a potentially superior alternative to existing vaccine models with less structural definition and costlier timelines. The main objectives are 1) demonstrate our synthetic technology platform for the gram-scale production and se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel radical chemistry for complex peptide synthesis and engineering' (NORACHEM) under Seventh Framework.

assistant: **Objectives**

Natural products are a constant source of inspiration in chemistry and have played a key role in the development of medicine. Recently, thanks to the progress in genomics and metagenomics, it has appeared that the biosynthetic potential of microorganisms and the complexity of the reactions catalyzed have been largely underestimated. Notably, enzymes using radical-based chemistry have been shown to be present in a very-large amount of biosynthetic pathways and to be widely distributed among all living organisms. The highly reactive radical species they generate give access to chemistries not accessible otherwise and allow them to catalyze unique and diverse reactions. Among them, the so-called ""radical SAM enzymes"" have attracted considerable attention in recent years. While, initially hypothesized to be a family with several hundreds of members, recent genomic analyses have revealed that there are several tens of thousands of radical SAM enzymes catalyzing more than sixty distinct biochemical processes.Very recently, an ever increasing number of radical SAM enzymes has been discovered in the biosynthetic pathways of natural compounds. In several cases, it has been shown that, instead of involving non-ribosomal or polyketide synthases, microorganisms use radical SAM enzymes to extensively modify ribosomally synthesized peptides producing highly complex bioactive molecules. In the present project, we propose to develop a multidisciplinary approach to investigate promising radical SAM enzymes catalyzing peptide modifications and elucidate their unique mechanisms which, in many cases, have no counterparts in biochemistry and synthetic chemistry. Based on the unique and highly conserved radical SAM domain and the mechanistic insights gained, we will develop novel radical S