RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NORDIC DRIVING - SOLUTION FOR TRANSPORT' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Numerous conditions can affect a person’s ability to walk unassisted and severely limit their independence and quality of life. Patients in rehabilitation and the elderly are two groups with specific need for innovative solutions to join mobility and exercise in a way which is practical, safe and fun. At Torqway Company Ltd. (www.torqway.com) we have created a new category of personal transport: Nordic Driving, using levers to power the vehicle from a standing position like a Segway.This innovative solution under patent in 11 countries meets all the criteria of a healthy and environmentally friendly and won numerous awards including the “BEST INVENTION OF EUROPE 2014” at the INPEX USA, the first time for a Polish company.Hybrid S-TORQ consists of a platform with two front wheels and a pair of smaller rear wheels. The back and forth movement of the extensible levers attached to the front wheels propels the vehicle forward. Thanks to the innovative gears mounted inside each driving wheel every lever movement is productive in powering the vehicle forward, reaching a speed of 12 km/h compared to human preferred walking speed of around 5 km/h.Medical studies confirm the therapeutic benefits of regular activity on TORQWAY on muscle strength and endurance, coordination, body balance, respiratory system and the circulatory system. It can be used by patients of all ages with orthopaedic, neurological, cardiac or pulmonary disorders for rehabilitation, recreation and improved mobility.Having developed, patented and successfully commercialized the basic model S-TORQ our goal is to upgrade the solution for end users who for reasons of age or physical limitation require an additional source of propulsion to enjoy TORQWAY to its full potential. The aim of this project is to prepare f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Network Inpainting via Optimal Transport'.

assistant: **Innovation**

The precise digital reconstruction of natural networks such as blood vessels or plant roots is crucial to ensure the quality ofsimulation-driven predictions. However, these structures can often be accessed only via noninvasive techniques, leading to artifactsthat compromise the reliability of the data and the derived simulations. No technological solution is currently able to recover digitalreconstructions of ""real"" networks from corrupted images.The NIOT (Network Inpainting via Optimal Transport) project aims to fill this technological gap by defining for the first time a robustmathematical formulation of the image network reconstruction problem. Thanks to the most recent advances of the optimaltransport theory, we will finally encode into equations the well-known fact that several natural networks are designed to transportresources with the least effort possible. We will adopt a variational image processing method, where the reconstructed network isobtained as the density minimizing the sum of the discrepancy with the observed data and a branch inducing functional. As such, ourproposed methodology builds a bridge between the image regularization and optimal transport communities.A major ambition of the project is to pair the theoretical analysis with robust simulation tools that are capable of handling real dataarising from MRI acquisition techniques. This will require exploitation and development of dedicated components to handle largedatasets, both from a data handling and a multiscale simulation perspective. Our algorithm will be tested on a sequence ofincreasingly channeling problems. We will start from simple synthetic networks, then we will use an high-quality map of the bloodvessel network of a mouse brain. The final benchmark will be to reconstruct of corrup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'KiD: A low-cost KInematic Detector to assist early diagnosis and objective profiling of ASD'.

assistant: **Objectives**

Autism spectrum disorders (ASDs) are a heterogeneous set of neurodevelopmental disorders characterized by deficits in social communication and reciprocal interactions, as well as stereotypic behaviours.  Although early diagnosis followed by appropriate intervention appears to offer the best chance for significant health improvement and economic gain, diagnosis of autism remains complex and often difficult to obtain. Recent identification of atypical kinematic patterns in children and infants at increased risk for ASDs provides new insights into autism diagnostic and objective profiling. KiD intends to help move these insights into the development of a low cost, easy-to-use, yet reliable wearable tracking system, designed to assist detection and classification of ASDs. The novelty of KiD is to combine informed development of machine learning methods to classify kinematic data with a co-design human factor engineering. KiD holds great potential for translational possibilities into autism clinical practice.  The main use of the device will be to assist clinicians to achieve expedited diagnosis, ensuring early and timely access of children at risk of autism to evidence-based intervention programs. Another use will be to examine the quantitative nature of autistic traits, enabling new forms of precision-phenotyping, which is potentially useful for stratifying patients with ASD and developing individualized treatment approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next generation Sepsis pathogen diagnostics: Revolutionary device for rapid detection of Sepsis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

49M patients are diagnosed with Sepsis and 11M die annually worldwide and costs over €30 billion to treat. This is a senseless tragedy as 80% of sepsis deaths could be prevented with rapid diagnosis and treatment.SepTec is the groundbreaking, cost-effective technology required to provide the solution. SepTec is a patent-pending in-vitro diagnostic device that screens blood for the diagnosis of sepsis infection, detecting and identifying pathogens within 15 minutes at very low concentrations (<10 CFU/ml) without the need complicated lab tests. Preliminary health economics research shows that our rapid Sepsis infection diagnosis will result in patients receiving the correct treatment between 2 and 4.5 days earlier than in current protocols (resulting in a consequent 50% reduction in mortality rate), 25 times fewer patients receiving unnecessary antibiotics and a healthcare saving between €17-40m per 5m population.The global point of care market is expected to be valued €50.51bn by year 2026, (CAGR of 9.6%). Within this market, the market for point-of-care tests (POCT) for infectious diseases (including sepsis) is €3.7bn annually and sepsis specific POC diagnostics testing market is expected to grow from €1bn by 2026. To exploit this lucrative market opportunity, we must complete an innovation project to progress our highly promising results into a product suitable for a large-scale clinical validation, mass manufacturing and subsequently commercialization.


**Keywords:** Sepsis, infection diagnostic, POC, near-patient, cell biology, bacteriology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Signal Transduction and Epigenetic Mechanisms of Breast Cell Plasticity and Cancer'.

assistant: **Concept**

Breast cancer is diagnosed in ~1.4 million women worldwide and ~500,000 lives are lost to the disease annually. Patients may do well after surgery and initial treatment, but drug resistant and fatal metastases often develop. Improved treatment options are urgently needed. The connecting thread of this project is the identification of epigenetic drivers of breast cell fate, tumor heterogeneity and metastasis.Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis and is one of the most important and clinically relevant areas of cancer research. Tumor heterogeneity results from genetic and epigenetic alterations that enhance the plasticity and fitness of cancer cells in the face of hurdles like the metastatic cascade and anti-cancer therapies. Unfortunately, the driving molecular mechanisms remain unclear, particularly the potential interplay between signalling pathways and epigenetic programs.This interdisciplinary project uses pathophysiologically relevant models and state-of-the-art technologies to identify molecular mechanisms underlying crosstalk between key signalling pathways and epigenetic programs in the normal and neoplastic breast. We hypothesize that interfering with these programs will decrease tumor heterogeneity.We will address the effects of:-SHP2/ERK signalling on the epigenetic programs of tumor-initiating cells (Aim 1)-PI3K pathway hyperactivation on the epigenetic programs underpinning cell plasticity (Aim 2)-Epigenetic regulators on normal mammary cell self-renewal and on metastasis (Aim 3)By investigating the integrated effects of key signalling pathways and epigenetic programs in normal and neoplastic breast, this multipronged project will identify and validate mechanisms of cell plasticity. The derived mechanistic understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'REstoring rivers FOR effective catchment Management' in the context of a Seventh Framework call.

assistant: **Objectives**

REFORM is targeted towards development of guidance and tools to make river restoration and mitigation measures more cost-effective and to support the 2nd and future River Basin Management Plans (RMBPs) for the WFD. Aims of REFORM are (1) to provide a framework for improving the success of hydromorphological restoration measures and (2) to assess more effectively the state of rivers, floodplains and connected groundwater systems. The restoration framework addresses the relevance of dynamic processes at various spatial and temporal scales, the need for setting end-points, analysis of risks and benefits, integration with other societal demands (e.g. flood protection and water supply), and resilience to climate change.The consortium comprises scientists and practitioners covering a wide range of disciplines (hydrology, hydraulics and geomorphology, ecology, socio-economics). The workplan is organized in three modules: (1) natural processes, (2) degradation, (3) restoration. Data from monitoring programmes and restoration projects will be pooled and linked with landscape-scale hydromorphological and physiographic data and catchment models. Targeted field and experimental studies using common protocols will fill data gaps on the role of scale in restoration success. A wide range of statistical modeling approaches will improve indicators for hydromorphological change and factors determining restoration success. All work packages are multidisciplinary and will feed into products for application in river basin management, e.g. guidelines for successful restoration and a web-based tool for exchanging experiences with river restoration measures facilitated and enhanced through consultation with stakeholders.In addition to its impact on the RBMPs, REFORM will provide guidance to ot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A medical device determining the daily amount of breast milk to improve neonatal nutrition andmothers’ psychophysics well-being.' (Galastick).

assistant: **Concept**

Biological diversity among people, reveals that not all mothers are the same. For some of them (not a few) it occurs that theyare not able to successfully breastfeed their babies. Breastfeeding without ""feeding"" can cause frequent crying and colic inthe newborn and nervousness in mothers, lack of confidence in their abilities and depression. A mother starts to feelinadequate, undermining her psychological wellness. On the other hand, several mothers have breastmilk in excess andcould donate it to preterm infants in midwiferies, thus promoting the babies' health and reduce hospitals' costs.Galascreen developed a proprietary disposable medical device, GalaStick, determining the lactation onset and theprogressively increasing daily amount of breastmilk. The stick uses a lateral flow immunochromatographic assay that workssimply detecting the presence (or absence) of a target analyte in the human milk sample. Such an easy to use stick not only improves the neonatal nutrition (warning if any feeding integration is needed), but also the psychological well-being of the mother. GalaStick has reached TRL 6 since a preliminary prototype has been tested with real human milk samples. More than 150 volunteer mothers and human milk donor mothers were successfully screened. Galascreen requires funding to engineer and industrialize the stick prototype and to get it medically certified as a medical device. Both key processes will be supervised and supported by the SME partner Omini Pharma. Phase 1 project will address a deep study on business development strategy and will define the value chain and the commercialization plan, together with assessing the regulatory procedures and certifications to be obtained by both the product and the company in order to be an active player on the med
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DISSECTING GENETIC DEPENDENCIES IN CANCER', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

While significant progress has been made in the diagnosis and treatment of cancer, several major issues remain unresolved. First, only a minority of patients respond to most forms of (chemo)therapy. It is generally believed that this poor responsiveness to drugs has its origin, at least in part, in the molecular heterogeneity of cancer. This heterogeneity requires the use of biomarkers to stratify patients having seemingly similar tumors according to their likely responses to specific cancer therapies. To identify such biomarkers, we will use large-scale genetic screens to identify genes that are causally involved in controlling responses to cancer drugs. Such genes are likely biomarkers of drug responsiveness in the clinic. Availability of such drug response biomarkers will facilitate a more personalized therapy choice for each individual patient. A second major deficit in effective cancer therapy is the lack of sufficient highly selective drug targets. The large-scale cancer genome re-sequencing efforts already indicate that there is a paucity of druggable genes that are consistently mutated in cancer and the same holds true for genes that are consistently over-expressed in cancer. Hence, there is an urgent need for innovative drug targets that have a similar cancer-selectivity as the genes that are specifically mutated or over-expressed in cancer. In this project, we will use large-scale loss of function genetic screens, exploiting the concept of synthetic lethality , to identify genes whose inactivation is selectively toxic to cells having a defined cancer-specific genetic alteration. Drugs against these targets will be highly cancer-selective, as their activity hinges on the presence of a specific genetic defect, which is only present in the cancer cell.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Cyprus Solar Thermal Energy Chair for the Eastern Mediterranean'.

assistant: **Concept**

The CyI Solar Thermal Energy Chair for the Eastern Mediterranean (CySTEM – Chair) proposal aims in consolidating and upgrading the already substantial activity at the Cyprus Institute (CyI) in Solar Energy, principally solar-thermal and related activities. This will be accomplished by attracting and installing a cluster of outstanding researchers, led by a professor of international stature to maximally utilize and upgrade the existing facilities, and pursue a program of excellence in Cyprus with local and regional focus in the region of Eastern Mediterranean and Middle East (EMME).The principal focus will be on Concentrated Solar Power (CSP) technologies for electricity production, desalination, air conditioning and heating, either in isolation or in multi-generation modes. The Chair shall be embedded in CyI’s Energy Environment and Water Research Centre (EEWRC), a Centre with intense activity in climate change (and adaptation strategies), water management, and sustainability. CyI, being a technologically orientated research and educational institution, will provide the CySTEM Chair the opportunity to contribute to other related important activities of techno-economic nature, such as the definition of a road map for Renewable Energy Sources (and Solar in particular) development in the area in light of the recent discoveries of substantial Natural Gas deposits in the Eastern Mediterranean.Following the template provided by the Commission, the proposal first presents the main objectives of the chair. This is arranged in subsections to describe what is proposed (research activities), who will carry it out (human capital), what infrastructure and tools will be employed to enable the realization of the proposed program and how the various tools and policies available to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evolution and molecular mechanisms of adaptive organ allometry in Atlantic salmon (Salmo salar)' (SalmoScales) targeting Horizon Europe.

assistant: **Abstract**

Species radiations can be driven by changes in body proportions (allometric changes), that is, natural selection acting on size and not in shape. Discovering the genetic and developmental basis of allometry has both fundamental importance for understanding the emergence of biological diversity, as well as in practical terms such as in understanding cancers. Only a few allometry mechanisms are known to explain adaptive differences in organ size within a vertebrate species. The SalmoScales project will fill this knowledge gap by discovering the molecular, developmental, and evolutionary mechanisms that give rise to allometry of reproductive organs in Atlantic salmon (Salmo salar). Salmon show a fascinating adaptation of organ allometry associated with a trade-off in life history strategies; dwarf landlocked ecotypes prioritize egg size over egg number, and in consequence have ovaries that are 50% smaller compared to their sea-migrating congeners. The decreased ovary size in dwarf salmon provides a unique model to study how allometry emerges within a single species and interplays with life history strategy. Salmon reproductive development is governed by transcriptional regulators that include the genes vgll3 and six6. These genes are top candidates for mediating ovary allometry as my preliminary results suggest that vgll3 interacts with Hippo signaling pathway mediating organ size, as well as transcription factors controlling for germ cell development in salmon gonads. I will dissect the genotype-phenotype-fitness map of ovary allometry from the molecular to the species level with an integrative approach combining cellular genomics, gene editing, and a powerful quantitative genetics framework. The results will have applied significance in aquaculture to inform precision br