RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Boron chemistry in a new light: exploring the radical reactivity of boronate complexes through photochemical strategies' (PHOTO-BORAD) under Horizon 2020.

assistant: **Objectives**

In the last decade photoredox reactions have emerged as tremendously versatile processes for organic synthesis, enabling reactive radical species to be generated at specific positions in an organic molecule under very mild conditions (visible-light irradiation). Over the same decade the host group have developed a suite of transformations exploiting the fundamental chemistry of boron, many of which involve 1,2-metallate rearrangement of boronate complexes. We now seek to merge these two major pillars of synthetic methodology, which are currently unconnected, to create a new field which we believe has significant potential for organic synthesis. We propose to react electrophilic radicals generated through photoredox catalysis with vinyl boronate complexes. Oxidation of the resulting intermediate radical during the photoredox cycle will trigger 1,2-alkyl migration, creating new C-C and C-B bonds. 1,2-Metallate rearrangements normally employ leaving groups adjacent to boron but here we are proposing to oxidise a radical adjacent to a boronate to achieve the same transformation, a process that has not been previously reported. 1,2-Metallate rearrangements are stereospecific, and this will be exploited in the creation of enantioenriched products starting from readily available chiral boronic esters. The scope of the process will be carefully investigated, and mechanistic studies will be carried out using advanced physical/chemical methods, thereby laying solid foundations for the development of this new field. By combining two major fields of endeavour, novel chemistry will emerge with new structures harbouring novel properties for exploitation. Furthermore this project will enable significant knowledge transfer between host and researcher, while forging new academic network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of anti-melanoma therapies: the animal model stage.' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Susceptibility genes and environmental factors contribute to the rising incidence of melanoma in Europe. Tumor associated antigens on melanomas can be recognized by immune effectors. These antigens are the focus of immunotherapy protocols. Information is lacking, however, concerning expression of tumour associated antigens and the activation status of immune effectors at initial stages of tumour suppressor gene in melanocytes. The concordant expression of a tumour associated antigen will allow monitoring of the activation status of antigen-specific lymphocytes during tumour progression. This information is essential for the design of tumour antigen vaccination and other therapeutic protocols. This project requires a pluridisciplinary effort by groups involved in(i) development of models of oncogenesis by somatic genetics in mice;(ii) identification of melanoma associated antigens in humans and;(iii) monitoring activation or inactivation in vivo and targeting of immune effectors or antigen presenting cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Validate of TSAA coating technology. Development of procedures and standards manual. Technical and economical study' (VALIDATETSAA) under Seventh Framework.

assistant: **Objectives**

The proposed project will focus on the validation of a TSAA process, including pre- and post-treatment, which is defined by the topic manager, and its implementation in industrial scale. An existing industrial plant, which will be selected by the topic manager, will be benchmarked with respect to the number and dimensioning of the components of the plant and its periphery with respect to the technical requirements for the process. The process itself will be performed in laboratory- and pilot scale to verify the reproducibility of the process for given aluminium alloy(s) and to characterize and quantify the properties of the surface of specimens after each step of the TSAA process. Failure mode analyses, such as FTA (failure tree analysis), DRBFM (Design review based on failure mode) and FEMS (Failure modes and effects analysis) will be performed. Knowledge-based analysis of the process and the relevant parameters, such as temperature and filtration, as well as the aforementioned failure mode analysis, will lead to the definition of process sheets and risk assessment plan. Environmental analysis of the process will consider chemicals used – also with respect to REACh compliance -, exhaust fumes (especially in the working area), waste and waste water output. As far as possible, recycling routs for process waters and chemical components will be analysed and suggested. Risk analysis will also include possible health risks in the working area, which can origin by incorrect use of chemicals or waste. The results of the analysis of environmental and health risks will be included into the process sheets and risk assessment plan. Data and process-relevant knowledge gained during the aforementioned analysis steps will finally lead to elaboration of a manufacturing plan and compil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Motion capture', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

There are three main objectives in MOCA: 1. to enhance the field of application of optical motion capture 2. to enhance the performances and the realism achieved by motion capture 3. to make motion capture systems more robust and more user-friendly so that a lot of multimedia companies can acquire such a system.To achieve these objectives, two main approaches are used: - to enhance the performances of motion capture acquisition: the capture field will be drastically enlarged by allowing the use of moving cameras which make permanent recalibration in order to know the relative position of all the cameras special techniques will be used for the capture of some detailed parts of the human body. - to use human modelling for improving motion capture: a model of the human body will be used whose complexity will be adapted following some criteria that can change from one pilot to another this model will give instructions for the positioning of the markers which is still experimental today the tracking of the markers will be far better by using a mathematical model for predicting the temporal evolution of their position an anatomic converter will be designed in order to adapt the tracks of the markers to models with different topologies and/or different morphologies (other humans, robots, monsters, ...). The two technological providers (ACTISYSTEM and EPFL) will perform those developments during the first phase of the project so that a first evaluation of the expected progress will be available very soon. Afterwards, 3 pilots will be designed, each being part of a commercial product belonging to a major segment of the multimedia market. They will allow the end-users to improve their know-how related to motion capture and to address their respective markets with very high-level
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Movement and Migration in Irish Prehistory' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of this project is to achieve a better understanding of human population movements and migrations during the Mesolithic and early Neolithic periods in the Atlantic regions of northwest Europe. The investigation will especially focus on the role of such movements in bringing about social, cultural and economic changes in Ireland and Britain, including the arrival and spread of agriculture. This will be achieved through conducting original isotope analysis of human and animal remains from the region and integrating the results of this work with genetic and traditional archaeological evidence for population movements in early prehistory. As a vital part of the project the fellow will develop research excellence in all aspects of isotope analysis and additional competencies that will allow him to lead a research team engaged in a wider programme on population movement and migration in early prehistory. This will give the fellow the opportunity to build on his extensive knowledge of human movement and mobility in early prehistory and to develop expertise in a state-of-the art field of research, i.e. archaeological isotope analysis, which presently cannot be acquired in his home country.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improving resilience of sensitive industrial plants & infrastructures exposed to cyber-physical threats, by means of an open testbed stress-testing system' (InfraStress) under Horizon 2020.

assistant: **Objectives**

InfraStress addresses cyber-physical (C/P) security of Sensitive Industrial Plants and Sites (SIPS) Critical Infrastructures (CI) and improves resilience and protection capabilities of SIPS exposed to large scale, combined, C/P threats and hazards, and guarantee continuity of operations, while minimizing cascading effects in the infrastructure itself, the environment, other CIs, and citizens in vicinity, at reasonable cost. In fact, InfraStress will develop TRL4+ solutions from preceding research and innovation towards TRL7 level producing maximum adoption of the proposed methods and solutions. Addressing the current fragmentation of available security solutions and technology, InfraStress will provide an integrated framework including cyber and physical threat detection, integrated C/P Situational Awareness, Threat Intelligence, and an innovative methodology for resilience assessment  – all tailored to each site. InfraStress adopts a user-driven approach carried out through: a) delivery of usable and user-friendly Services and Applications for C/P protection and resilience; b) technical activities driven by and receiving active input from end users, i.e. SIPS and relevant stakeholders; c) a comprehensive set of 5 real-world Pilots and Evaluation activities to be carried out by User partners. InfraStress matches key impacts not only in response to the Work Programme Call but also at Strategic, Socio-economic and Market levels. In fact InfraStress was conceived since the beginning with a strong business vision in mind and will carry out effective exploitation actions ensureing successful go-to-market. Tailored activities are also planned to rise a a culture of participatory security to involve all stakeholders including companies, workers, public authorities, citizens an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Global Ethics in Science and Technology' to be submitted under Seventh Framework.

assistant: **Abstract**

GEST aims to explore the role of ethics in science and technology (S&T) policy as it is currently developing both in Europe and in the two main global emerging economies of China and India. S&T ethics has been widely debated in Europe in the last two decades leading to a number of policy initiatives that have influenced the development of new technologies in the European Research Area. The way in which ethical considerations are incorporated in S&T policy in Europe creates an environment that inevitably affects the EU’s global position.At the same time Europe is increasingly co-operating and competing with the two major emerging economies of China and India, which are also keen to develop their S&T sectors. Interdependences between these three global actors require ever closer collaboration, preferably undertaken in a highly transparent manner. However S&T debates in each of the three regions follow local dynamics that are not necessarily easily understood, even by expert communities in those regions. Interdependent development (and even positive competition) requires mutual respect and understanding, but this relies upon close collaboration in exploring common issues and significant differences.GEST aims to create such collaboration between key S&T policy advisory institutes in the three regions in order to provide a clear understanding of the role of ethics in S&T debates. GEST offers a unique chance to analyse and debate relevant issues while learning from experience gathered in Europe and in the two emerging economies. A group of experts with a wide disciplinary and geographical distribution will provide input for kick-starting a global debate on the dynamics of ethics in S&T policy. In order to address the implications for effective global governance of science, GE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Realistic Assessment of Historical Masonry Bridges under Extreme Environmental Actions'.

assistant: **Objectives**

The RAMBEA project will develop a novel computational strategy for accurate and efficient simulations of historical masonry bridges subject to extreme environmental actions, including loadings induced by earthquakes and flooding. The aim is to provide a comprehensive tool for realistic assessment with the potential of transforming current practice related to strengthening of critical assets, contributing to an increased resilience of the built environment and the preservation of important elements of the architectural heritage, thus responding to the safety and socio-economic needs highlighted in Horizon 2020.Old masonry bridges still play a critical role within the European transportation system. Moreover, they belong to the architectural heritage representing a valuable expression of past construction technology. Many of these structures are located in seismic regions and in areas subject to floods and hydrogeological instability which have been aggravated by climate change. Thus they can be exposed to extreme environmental actions which may potentially lead to bridge failure causing significant economic damage and the loss of structures with cultural and historical value. Currently, the response of masonry bridges under extreme loading is evaluated using simplified models due to the lack of efficient detailed models. However, these approaches do not allow for the complex 3D behaviour potentially leading to unrealistic and unsafe predictions. The main challenge of this project is the development of a more advanced strategy, based on a novel numerical description allowing for the 3D interaction between the different bridge components under extreme loading. More specifically, I will develop an efficient 3D finite element representation with macro-elements for the masonr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nanobodies and antibodies against 2019-nCoV', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Overview:As of Feb 12th, 2020, the death toll of the 2019-nCoV (COVID-19) epidemic has surpassed 1000, rapidly eclipsing the total mortality of SARS. It has a current death rate estimate of around 2 deaths per 100 confirmed infections, is experiencing phenomenal growth in mainland China, and has the potential to spread globally over the coming months. While a vaccine may be useful for future epidemics of a similar virus, it is not clear that such a vaccine can be produced at a speed and scale sufficient to impact the current epidemic.Objective:Antibodies form the basis of a robust adaptive immune response to viral disease. Nearly all licensed vaccines mediate protection through the activity of antibodies and where vaccines are not available, passive infusion of monoclonal antibodies can fill the gap and control the infection. The overarching goal of the CoroNAb consortium is to rapidly identify, validate, and disseminate pre-clinical protein therapeutic candidates with neutralizing activity against 2019-nCoV, and to recommend where their use would be maximally effective.Expected results:Over the course of the project, we expect to design and synthesize recombinant variants of nCoV glycoproteins for immunization in mice, alpacas and macaques in order to generate and characterize multiple nCoV-neutralizing antibodies and nanobodies. We will develop efficient assays for the testing of such antibodies and exploit novel computational workflows to improve neutralizing antibody potency. Finally, we will employ mathematical modeling of the 2019-nCoV epidemic for forecasting intervention effectiveness.Timeline:We expect the project to deliver a number of nCoV neutralizing anti- and nanobodies of increasing potency over a 2 year period from start date.


**Keywords:** Monoclonal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced skills for data analytics in neurological diseases' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The NeuroInsight Fellowship programme, led by RCSI, will offer a combination of Incoming and Global, 24-month fellowships to 33 Experienced Researchers (ERs) at the interface of the two, world-leading Science Foundation Ireland (SFI) Research Centres; FutureNeuro and Insight. The vision of NeuroInsight is to deliver the future generation of research leaders equipped with the skills to assemble, integrate and mine, using machine and deep learning, a wide variety of data types to yield novel insights into high-definition precision medicine for neurological disorders. We will offer individually-tailored, as well as programme-wide training in aspects of relevance to all recruited researchers, including advanced research skills, transferable skills and experience in industry and or/clinical settings. NeuroInsight helps meet the diverse challenges presented by COVID-19 and is adaptable to associated restrictions. Our intersectoral partners (industry, clinical and patient groups) will take an active part in the Fellows’ progression, through compulsory intersectoral secondments, clinical events, interdisciplinary short visits and specialized training. NeuroInsight is patient-focused, prioritising their needs in training activities and research. We will enable fellows to develop their research-specific and transferable skill sets to actively interact, collaborate and engage with industry, clinical partners and patient groups, and create a culture of patient-centric entrepreneurship. The net result of NeuroInsight will be research leaders equipped to transform the patient journey for people with chronic and rare neurological conditions. Adhering to the COFUND principles, applicants will freely choose, according to their individual preferences, from a wide range of research fields