RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metabolomics of single eukaryotic cells' (MESEL) targeting Seventh Framework.

assistant: **Abstract**

We propose to develop an analytical platform for single-cell metabolomics and apply it in fundamental studies carried out on a model eukaryotic organism, Saccharomyces cerevisiae. Due to the minute amounts of metabolites present in each cell, almost all current methods used in biochemistry and molecular biology provide data that are averaged over an entire cell population while even cells in monoclonal cultures display profound variations on all physiological levels. This approach to molecular biology is dramatically altering our view of the key questions in cellular function and interplay. The ultimate quest for a quantitative and mechanistic model comprising cellular processes requires a new methodology. The proposed single-cell metabolome studies will be achieved through microfluidic cell processing for sample preparation, on-line microscale separation of metabolites and detection by a high sensitivity mass spectrometric method. Our single-cell approach to metabolomics research will permit us to collect data on the cellular metabolome, which can then be utilized for the modelling of cellular metabolism. This new platform for systems biology can find numerous applications ranging from fundamental cell science to personalized medication.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New enzymes by identification from metagenomic libraries and directed evolution using microfluidic microdroplets' (METAPROMIS).

assistant: **Concept**

The usage of Nature’s catalysts for industrial applications is promising to be one of the central pillars of sustainable European chemistry, due to the reduced environmental impact of ‘green’ biocatalytic processes compared to current hazardous chemical procedures. However, at present a large fraction of chemical transformations cannot be substituted with biotechnological production lines, because suitable biocatalysts satisfying the criteria are not known. Our incomplete understanding of enzyme mechanisms makes it difficult to generate catalysts de novo with protein design techniques. An alternative route is the identification of biocatalysts from the natural collections of evolved proteins that fit into the catalytic task to some extent (a phenomenon known as catalytic promiscuity) and improve their catalytic performance for the desired reaction by directed protein evolution techniques. In order to reach this strategic goal, we aim to employ a new high throughput technology (in vitro compartmentalization in microfluidic water-in-oil emulsion droplets) in the search for new biocatalysts. By this assay technology, previously inaccessibly large enzyme libraries will be screened. After isolation of the target enzymes from microbial metagenomes, the latest protein evolutionary theories in relation to catalytic promiscuity will be investigated on a large set of natural enzyme variants, in order to elucidate how new activities are evolved in nature. The resulting aspects of evolution of new enzyme functions could provide an intellectual framework to rationalise evolutionary developments and to utilize these principles for evolution in the test tube for relevant applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stochastic pattern formation in biochemical systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

There are basically three mechanisms for spatial pattern formation in systems of two coupled reaction-advection-diffusion equations; the Turing patterns, patterns created through reaction kinetics, and chemotaxis patterns. We are interested in the reaction-diffusion equation with underlying chemotaxis. The terminus chemotaxis refers to oriented movements of cells (or an organism) in response to a chemical gradient.   The topic of the proposal to investigate the logistic grow equation with underlying chemotaxis. This system will be perturbed by a stochastic noise term, modelling neglected fluctuations or random perturbations from outside. The stochastic term leads to new phenomena, e.g. bifurcation are smeared out,  metastability may happen, or sudden shifts to other, possible undesired, states.   First, the existence and uniqueness of the solution should be investigated; then the long term behaviour will be analysed. Here, also the dynamical behaviour should be characterised. The third point, we will focus on is the numerical approximation of the system.


**Keywords:** Stochastic Analysis, Stochastic Partial Differential Equations, Mathematical Biology, Pattern Formation, stochastic cross diffusion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Transgenic releases, analysis of gene flow and fluctuations in indigenous bacteria communities' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Backqround: Bacteria are among the best-known organisms in terms of their genomes and laboratory genetics, but paradoxically their population genetics and interactions in the field are poorly understood. The biotechnological significance of this is clear: it is relatively easy to make novel genetic constructs, but difficult to predict the consequences of releasing them in the field. Bacterial population genetics urgently requires further development, both more empirical knowledge (from new molecular tools and better strategies for sampling populations) and a firmer theoretical framework (especially a clearer understanding of the relative importance of different gene transfer processes). Rhizobia, the nitrogen-fixing symbionts of legumes, are priority organisms for such studies because they are of biotechnological importance as well as an excellent model system. The use of commercial rhizobial inoculants is an established agricultural practice, and there is a long history of agronomic, genetic and ecological studies. Experimental genetically modified (GM) inoculants have been released, and there is potential for commercial use of modified strains in the forseeable future. The aim of the TRAFFIC consortium is to provide baseline knowledge of the genetic structure of indigenous populations, and to assess the impact of GM releases against this baseline. We shall analyse gene flow within rhizobial populations, between rhizobia and other bacterial groups, and between GM release strains and the indigenous community, and examine the fluctuations in the genetic composition of populations that arise through normal agricultural practice. Measureable objectives: - quantitative monitoring of gene transfer to/from GM releases - development of molecular tools to detect genetic element
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Manufacturing and testing of an allogeneic gamma delta T cell therapy for the treatment of cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

Europe is experiencing an unprecedented cancer epidemic, driven by our ageing population. Traditional cancer treatments such as surgery, chemotherapy and radiation therapy have demonstrated very limited efficacy for patients with late-stage disease and often cause considerable side effects.Cell therapies are the next breakthrough in oncology, but autologous cells must be harvested from each patient, expanded for several weeks in vitro and re-administered to the same patient while hospitalized. TCB, a Scottish SME, brings the first allogeneic gamma delta T cell therapy (OmnImmune) where T cells harvested from healthy donors are used to treat multiple recipients. OmnImmune represents a truly disruptive, step-changing approach to the treatment of a wide variety of cancers. It has the potential to be manufactured for large market segments at a lower cost than competitors and provide valuable increases to the quality of life of life.OmnImmune will provide next generation cancer treatment at 20% of the cost of any other cell therapy, saving €24Bn per year for 60,000 patients treated.OmnImmune’s unique characteristics make it a truly disruptive treatment solution for patients and clinicians:Multifunctional treatment solution: available to all cancer patients, regardless of their disease grade or immune statusPredicted high safety profile: minimal side-effects based on clinical data from trials of autologous GDT cells (to be confirmed in dose-escalation clinical trial)Ease of use and lower cost: frozen dose-ready units available for immediate patient administration.The SME Instrument funding will accelerate the development of the OmnImmune therapy and reduce its time to market from 10 years to 6 years. This will allow OmnImmune to reach the market by 2024.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Carbon nanotubes for large area displays'.

assistant: **Objectives**

Displays are an essential element for electronic access and communication of information for the information age". The convergence of the TV world and the information society lead to conceive new displays with a large area for HDTV purpose and portability capabilities. Thanks to the large area displays developed in the project, users will have access to home cinema systems provided by the new wireless communication systems. These displays will be able to provide the same quality as CRT displays. The project will study various CVD based growth methods (pulsed laser arc deposition, unbalanced magnetron sputtering, CVD, HPCVD, PECVD, Vacuum Arc deposition) in order to select the method, which will allow to grow CNTs on large area glass substrates. The best method will be used to fabricate equipment allowing to grow at least 15' displays. Thanks to the use of CNTs, new triode structures will be conceived for more reliable low cost high performance displays. Six-inch colour displays will be fabricated as an intermediate step to validate the growth improvement results. Finally the project will demonstrate the use of CNT on specific structures for the fabrication of 15'' colour displays.Objectives:Large area Field Emission Displays (FED) will provide to the user the possibility to access to home-cinema services, one of the major services provided by the emergence wireless communication systems. The CANADIS project is defined in order to develop a technology allowing fabricating low cost large area FEDs (more than 40') for TV applications. A 15' demonstrator will be fabricated in order validate the concept.Therefore, the project intends to:i) study localised growth of nanotubes based on CVD method (pulsed laser arc deposition, unbalanced magnetron sputtering, CVD, HPCVD, PECVD,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Advancing Lactobacillus’ beneficial potential'.

assistant: **Concept**

Lactobacillus bacteria have a strong, but underexplored potential as sustainable bio-based solutions for many food and health-related problems. Since Nobel-laureate Eli Metchnikoff hypothesized that lactic acid bacteria can promote human health in the gut, the research on lactobacilli and probiotics has mainly focused on the human gut and fermented dairy foods. However, a major knowledge gap exists on the beneficial potential of Lactobacillus species in other human body sites (vagina, skin, upper respiratory tract), animals (e.g. chickens, honey bees), plants, crops, and even on abiotic surfaces. In addition, lactobacilli play a key role in many plant- and vegetable-based fermentations, where they promote the shelf life and nutritional value of food and feed. Yet, why and how Lactobacillus species can be beneficial in such a wide variety of niches is currently underexplored. Therefore, the core aim of this project is a systematic and integrated analysis of the evolutionary history, ecology, and beneficial functions of Lactobacillus species. I propose an unconventional approach situated at the intersections of molecular microbiology (focusing on a single microbe), molecular ecology (focusing on microbial communities) and comparative genomics with an evolutionary perspective on niche adaptation of lactobacilli. By looking deeper into Lactobacillus biology, a paradigm shift can be made moving from a classical ad hoc base to a unique knowledge-based framework for strain selection and analysis of fitness and performance.


**Keywords:** probiotics, mode of action, evolutionary history, niche adaptation, niche flexibility, bacteria-host interactions, exopolysacchariden, non-ribosomal peptide synthetases
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Thematic network for Supporting Methods of management Systems for suppliers and consumers, E-Work and E-commerce in the MARitime World' under Fifth Framework.

assistant: **Concept**

Aimed to insure a wider involvement and participation of Maritime End-Users in the EC RTD Framework Programmes, specially maritime SMEs for wider and adaptive services, based on understanding and sharing strategies, E-MAR will contribute to Stimulate the activity of Maritime players towards e-work and e-commerce and to sustain European maritime business towards the new skill base SMEs need to maximise profitability and employment.E-mar will evaluate medium and long term market needs with respect to:a) The type and volume of products and services within the currently addressed areas of the Maritime Transport Chain; investigate for areas relevant to the e-commerce and e-work but not yet addressed by the maritime industry RTD projects;b) the required Information Technological knowledge and ability by the industry to provide the market with the required products and services in sufficient quantities and at competitive prices. The added value of this TN is contained in the fact that it treats technology in relation with market and society needs from a medium and long term prospect hereby enhancing the technological coherence and synergy between the various areas of interest within the Maritime Industry: the Maritime Transport Chain and the Marine Resources.Objectives:E-MAR key objectives can be summed up as:- To identify gaps or shortcomings and to permit maritime SMEs to jointly identify needs for enhancing the competitiveness of the European Maritime Industry by using appropriate e-work and e-business; - To provide the basic ground for enhancing the understanding of innovation and by the promoting the IST programme with special reference to e-work and e-business Maritime Applications;- To generate a higher level of awareness at bottom and top level, which includes The Mari
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'European Union Contest for Young Scientists 2013'.

assistant: **Objectives**

The European Union Contest for Young Scientists, an initiative of the European Commission, was set up in 1989 to promote the ideals of cooperation and interchange between young scientists. The Contest is the annual showcase of the best of European student scientific achievement and as such attracts widespread media interest. The 25th EU Contest of Young Scientists will be organized from 20th to 25th September 2013, in Prague, the Czech Republic, at the exhibition grounds of Křižíkovy pavilóny, in the historical city center. The Host Organizer is the Academy of Sciences of the Czech Republic, together with the Center of Operations and Administration of the Czech Republic and in close cooperation with the Ministry of Education, Youth and Sports of the Czech Republic. The EU Contest gives students the opportunity to compete with the best of their contemporaries at European level. The young scientists also have the chance to meet others with similar abilities and interests and to be guided by some of the most prominent scientists in Europe. In this way, the Commission seeks to strengthen the efforts made in each participating country to attract young people for careers in science and technology. The EU Contest for Young Scientists is part of the Science in Society activities managed by the Directorate-General for Research and Innovation of the European Commission. Within the Framework Programmes for Research and Technological Development, and the European Research Area, Science in Society aims to build a more harmonious relationship between scientific endeavour and the European Society at large.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Chip Integrated Hydrogen Generation-Storage-Power Micro System' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The primary objective of the proposal is the development of a chip integrated hydrogen generator based on polymer electrolyte membrane water electrolysis with on-board hydrogen storage and an option for a bi-functional operation (as a unitized regenerative microfuel cell). The output of the generated hydrogen should be high enough to feed up to 50 mW.cm-2 microfuel cell at continuous operation, while enabling hydrogen storage capable to compete the conventional secondary batteries. The goal will be achieved by application of novel cost efficient nanostructured materials with enhanced catalytic activity and long durability, innovative technology for membrane electrode assembling based on microsystem processes, and precisely controlled reactant supply. The possibility for reverse operation of the system (as microfuel cell) will be addressed through deposition of composite bifunctional catalytic films and corresponding design modifications, including incorporation of hydrogen storage in the developed MEMS. The long term goal is the realisation of an integrated hydrogen generation–storage–power micro system for autonomous energy supply of wireless electronic devices. The host organisation (HO) has a high competence and internationally recognised achievements in the field of microsystem technology, proven by development and fabrication of variety of sensors, microfluidic, and medical devices. The researcher (R) is an experienced scientist with expertise in electrochemical material testing, electro catalysis, and hydrogen energy conversion. The competence of HO and R complement one another in an ideal way, building a strong basis for successful realisation of the project goals. The researcher will have excellent opportunity to acquire new theoretical knowledge and practical s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'KOALA FOCUS: A disruptive e-health approach to treat at home, attention deficits without drugs' to be submitted under Horizon 2020.

assistant: **Abstract**

Attention Deficit with/without Hyperactivity Disorders (ADHD) is a neurological disorder with a high societal impact: 2.5 M children are diagnosed, and 2-5 M Adults in Europe are non-diagnosed. 50% children are not medicated mainly due to drug refusal and high rate under medication face adverse effects and treatment rejection. Mensia has developed a revolutionary prototype, Mensia KOALA, to treat ADHD by means of neurofeedback at home and without drugs, using Artificial Intelligence techniques. Our new prototype version “KOALA Focus” aims to be the first affordable Gold Standard Medical Device for Precise Medical Neurofeedback friendly used at home, whatever the patient's age. Our prototype, currently at TRL6, is a breakthrough innovation thanks to disruptive combination: at home evidence based medical neurofeedback technology, the first reliable non-invasive and precise e-Health Digital Therapeutic, monitoring and treating various types of ATTENTION DEFICITS. Our business model is based on buy hardware cap via secured eHealth Mensia platform and pay per at home session. The ADHD therapeutic market is estimated to reach €21.5 B by 2024 growing at a CAGR of 6.2%. TOTAL ATTENTION DEFICIT market in Europe worth 5 M individuals. KOALA Focus, once validated by the appropriate clinical trials, can achieve up to 50% of regular prescribers from this addressable market in the EU. Mensia aim to set up a Gold Standard of Good Clinical Practices for Precise Medical Neurofeedback at home, capturing 20% (1 M individuals) of this addressable market: 2,5 M children EU + 2,5 M adults. We estimated that in 5 years (end of Phase 2 project), we will accumulate ~€120 M of Revenues at 40€ /session, accounting for ~5% of the EU market, earning ~€36M profit (ROI of 5.7), while hiring 60 new te