RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Hybrid Nano-Electro-Mechanical / Integrated Circuit Systems for Sensing and Power Management Applications'.

assistant: **Objectives**

NEMSIC addresses the future intelligent sensor and actuator systems in which solid-state semiconductor micro/nanodevices and micro/nano-mechanical devices are co-integrated for new functionalities and increased performance.The project proposes the exploration and development of low power sensing micro/nanosystems based on Nano-Electro-Mechanical (NEM) structures integrated on a Silicon-On-Insulator (SOI) or Silicon-On-Nothing (SON) technological platform. The applications that drive the technological NEM-based smart system demonstrators are gas (COx, NOx, SOx) and biological sensing (DNA, proteins and other molecules), dedicated to critical environment monitoring and applications in the fields of genetics, pharmacology and drug discovery. NEM technology will be combined with silicon CMOS technology involving novelty and scientific/technical challenges at three levels: (i) system level, addressing the challenge of true nano-micro interfaces, where signals detected by arrays of nanostructures are processed by smartly designed low power CMOS circuitry, (ii) device level, where novel true hybrid NEM-FET devices support new highly sensitive detection scheme and power management via sleep switches and (iii) technology level, where nanotechnology processes (top down processed nanobeams and nanogaps, featuring sub-100nm dimensions) will be developed and combined with advanced functionalization techniques for dedicated sensing that stays compatible with CMOS in future IC-embedded or post-IC approaches. The reliability of the NEM structures, combined with prospects for 0-level packaging are studied as key challenges for the success of such Nano-electro-mechanical-system-integrated-circuits (NEMSIC).Finally, NEMSIC is expected to provide the end-users with flexible design methodol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hydrogen Energy Applications for Valley Environments in Northern Netherlands' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

HEAVENN is a large-scale demo project addressing the requirements of the call, by bringing together core elements: production, distribution, storage and local end-use of H2 into a fully-integrated and functioning “H2 valley” (H2V), that can serve as a blueprint for replication across Europe and beyond. The proposed concept is based on the deployment & integration of existing & planned project clusters across 6 locations in the Northern Netherlands, namely Eemshaven, Delfzijl, Zuidwending, Emmen, Hoogeveen and Groningen, with a total initial investment of 88 M EUR. The main goal is to make use of green hydrogen across the entire value chain, while developing replicable business models for wide-scale commercial deployment of H2 across the entire regional energy system. HEAVENN aims to maximize the integration of abundant RES resource available in the region, both onshore (wind and solar) and offshore wind, using H2 as: (i) a storage medium to manage intermittent and constrained renewable inputs in the electricity grid; and (ii) an energy vector for further integration of renewable inputs and decarbonisation across other energy sectors beyond electricity, namely industry, heat and transportation. The project facilitates the deployment of 11 HFC end-user applications across the project clusters, while ensuring the interconnection between them. This will be delivered by facilitating the deployment of key transport & distribution gas infrastructure to deliver green H2 from supply to the end-user sites. In this way HEAVENN will demonstrate the coupling the existing electricity and gas infrastructures at scale, to decarbonize industry, power, transport and heat across the entire region. The scale of the deployment delivered by HEAVENN is sufficient to achieve by itself signific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional analysis of regulated clathrin heavy chain depletion in a vertebrate cell line' (1994-1998).

assistant: **Innovation**

Research objectives and content  We are exploiting the high rate of homologous recombination in the chicken pre-B cell line DT40 toinactivate the clathrin heavy chain gene (CHc) by gene targeting. We have generated CHc-heterozygotesbut failed to produce cells lacking both functional alleles, suggesting a lethal phenotype. To circumventthis problem we established cells expressing human CHc under the control of the inducible Tet-system.This will enable us to generate a CHc-null phenotype and investigate the functional consequences ofregulated clathrin depletion. The project aims to understand why the disruption of the CHc gene is lethal in DT40. The Tet-system will enable us to study the response of clathrin-mediated pathways to restricted CHc-levels and to investigate possible alternative pathways. Site-directed mutagenesis will gain new insight into the mechanism of clathrin-coated vesicle formation.  Training content (objective, benefit and expected impact)  Dr Jackson's group has experience in molecular and cell-biological aspects of clathrin function. Theculmination of this work, in a laboratory with expertise in the field of coated vesicle formation, will be the pursuit of our system to the point where functional studies can be conducted. In addition to the specificfacilities the biochemistry department can offer (see detailed proposal), Cambridge is also an excellent centre for related questions as there are several groups that have similar interests and that have aninternational reputation. Links with industry / industrial relevance (22)  None
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hand pose and gesture analysis for next generation device interaction', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

A touch-less, markerless interface for next generation Virtual Reality headsets and laptops (with embedded 3D sensors expected early 2015), will be possible only when accurate and robust finger and hand pose detection is available and developers can easily build applications with these natural interfaces. Solutions based on color cameras are problematic because of the restrictions on environment lighting, complex backgrounds and varied skin tones. A recent breakthrough during research within our current ERC grant has been the development of a highly efficient prototype system that is capable of real-time markerless fingertip and hand pose detection and analysis using 3D sensors. Exposing this functionality for future human-computer interfaces is an important and necessary step forward that will allow more intuitive and effective interaction with next generation computing systems. Upscaling our current prototype system and packaging its functionality for easy use by developers is precisely the innovation we aim to implement in this PoC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Peptide Dendrimers - A Chemical Platform for Functional Diversity' under Seventh Framework.

assistant: **Concept**

Peptides have emerged as a therapeutically important class of drugs and offer the advantage of great specificity, potency and low toxicity. Short circulation half-life, poor proteolytic stability and bioavailability have however prevented them from becoming a mainstream source of drug candidates. Dendrimers are versatile, derivatizable, well-defined branched synthetic macromolecules with promising properties for a variety of applications in technology and medicine. Combining therapeutic peptides with dendrimers represents a promising approach to overcome bioavailability limitations, while at the same time introducing novel pharmacological and biophysical properties. The impact of the dendritic structure and multivalency on potency, selectivity, bioavailability and overall pharmacology will be studied on nicotinic acetylcholine and oxytocin/vasopressin G-protein coupled receptors, two important biomedical targets. A synthetic strategy based on efficient ligation chemistry and combinatorial assembly of building blocks will form the platform for the assembly of diverse multifunctional peptide dendrimers. These peptide dendrimers will undergo detailed structural, biophysical and pharmacological characterization for their use as diagnostic tools and therapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Future Internet Impact Assurance' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Phase Three of the FI-PPP will fund somewhere between 400 to 1600 consortia and individuals as part of the sub call process foreseen in the 1.8 action line, spending over 80 million Euros in an attempt to multiply the uptake and impact of the Generic and Specific Enablers coming from previous FI-PPP investment. The objective of the FIMPACT Support Action is to collect and assess the quali-quantitative evidence of the potential socio-economic impact of the Future Internet –PPP by measuring and projecting potential take-up and impact of Phase III SME Accelerator projects to 2020, increasing the probability that those consortia and individuals selected will have the means and knowledge to deliver sustainable initiatives. First, FIMPACT will show these consortia exactly what factors create Impact and sustainability, not only in innovation and technical terms but also in technological, financial and market demand terms. Secondly FIMPACT will monitor and measure the progress and potential impact of the SMEs, Web entrepreneurs and projects of Phase III according to industry standards and the overall community of FI projects. The FIMPACT project will identify good practice and highlight consortia, SMEs and Web entrepreneurs who are achieving results with high Impact potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The interaction of the peptide penetratin" with a model membrane"'.

assistant: **Concept**

The aim of the proposed study is to elucidate the interaction of the 16 amino acid long peptide penetratin" with model membranes formed by phospholipid bilayers in order to improve the peptide efficacity and for a better comprehension of the organization of the membrane. The study will be done by depositing the bilayer on a solid substrate (i.e. silicon) by using the Langmuir-Blodgett technique (transfer of monolayers from the air/liquid interface to solid surfaces). Various techniques will be employed and primarily the technique of neutron reflection from which information will be gained on how the lipids reorganize around the peptide and let it pass through without water leakage. Selective deuteration will be possible to resolve the organization of the four components of the system, that is the hydrocarbon chains, the hydrophilic heads, the water molecules adjacent to the heads and the peptides themselves. Similar peptides with either hydrophilic or hydrophobic character will be used. A full comprehension of the system will be achieved by using techniques different and complementary to neutron reflection both available at the ILL and at the collaborating institutions such as ellipsometry, fluorescence microscopy, infra-red surface spectroscopy, near-field microscopy, differential calorimetry. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced Computational Model for the Development of Cochlear Implants' to be submitted under Horizon 2020.

assistant: **Abstract**

Cochlear implants (CIs) are proven effective in restoring hearing to the severe-to-profoundly deaf. Up to 2012, there were more than 100,000 CI users in Europe, which only accounts for 7% of all adult CI candidates. The most severe limitation of current CI technology is caused by the wide spread of electric current in the cochlea, which results in a poor spectral resolution of electrical stimulation of the nerve and limits the number of effective electrodes. Computational models of the cochlea have been used to facilitate the development of CIs. These models depend on the geometry of the reconstructed cochlea and the exact knowledge of the electrical impedances of different tissues. However, only crude estimation of the impedances of all media is available, and most computational models of the cochlea only adopted an ideal representation of the geometry. Therefore, CIModelPLUS aims to provide engineers an advanced computational model of the cochlea with incorporated CI, which will show improved accuracy of the electric current distribution in the tissues, in order to facilitate the development of next-generation CIs. To fulfil this aim, computational models of cochleae will be reconstructed from the µ-CT scans of temporal bone specimens, and the electric current distribution inside the cochlea will also be measured experimentally. The simulation and experimental results will later be combined to develop the advanced computational model of the cochlea. CIModelPLUS involves interdisciplinary research between engineering, physics, neuroscience and medicine, and intersectoral collaboration between academia and CI industry. It will lead to the future development of CIs due to the accurate and validated computational approach adopted, and the advancement of CI technology will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Revolutionising waste reduction from upcycled resources: Enabling waste-to-value for agro-food industry and natural cosmetics' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Globally, one-third of food production is wasted, leading to significant loss of resources and greenhouse gas emissions. Creating new, sustainable solutions to the problem of food waste is a pivotal goal of the EU. PURE-WAY aims to tackle this issue by fostering crosssectoral and multi-actor collaboration to devise new circular zero-waste solutions for fruit and vegetable waste. Together, we will develop cutting-edge biotechnologies: industrially applicable green solvents for extracting high added-value bioactive compounds; computational modeling-driven smart fermentation; and a next-generation eco-friendly composting system using specifically engineered synthetic microbial consortia. Through these innovative approaches, PURE-WAY will transform fruit and vegetable waste into functional foods with health benefits (2 functional beverages and natural cosmetics product), bio-based chemicals for eco-friendly solvents, and biofertilizers.  The resulting technological advancements will help address key food system challenges, natural cosmetics, providing safe, nutritious, healthy and affordable food, and supporting sustainable agriculture practices. The project integrates 11 partners from 8 countries, including 6 from Europe, 1 from South America and 1 from North America, merging 6 academic and 5 non-academic partners to facilitate   70 secondments (224 months), 13 between academic to academic (50 months) and 57 secondments (174 months) between academic to non-academic representatives. By fostering knowledge and markedly cross-disciplinary skill exchanges, PURE-WAY will substantially enhance research and innovation capacities through reaching well-defined objectives. This holistic approach will decisively contribute to creating a sustainable, circular food economy, aligning wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Overcoming the barriers and seizing the opportunities for active ageing policies in europe' under Fifth Framework.

assistant: **Concept**

Demographic ageing is a key challenge European policy-makers will face in the coming decades. An ageing society will strain European labor markets, pension systems and health care systems. Yet, demographic ageing also is a unique opportunity for Europe: increasingly, older Europeans represent a rich reservoir of skills and experience. Current reforms in these sectors have coped with demographic ageing by focusing on the supply-side of the equation. Recently, European policy-makers have demanded a more holistic and pro-active policy approach that reduces the demand for social and health care services in old age. These policies, so-called active ageing reforms, ensure that European citizens can actively participate in the economy and society in older age. The ActivAge project, then, identifies maps and analyses the socio-institutional, economic, and political realities facing the implementation of active ageing policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'In vivo engineering of monocytes loaded with nano-chemotherapeutic formulations: a novel live-cell mediated drug delivery system for the treatment of cancer' (MONONANOCHEM) under Horizon 2020.

assistant: **Objectives**

The success of current antitumoural therapies largely depends on the availability of appropriate drug delivery strategies, which have to allow the penetration of these drugs through the tumoural microenvironment. The knowledge related to the cellular heterogeneity of the tumours has advanced enormously in the last years. Tumour associated macrophages (TAM) can represent up to 50% of the tumour mass. TAM are derived from circulating monocytes, which are recruited from the peripheral blood towards the tumour in response to a broad range of molecular signals (i.e. cytokines). Recently several studies are focused on the development of therapeutic strategies targeting TAM, however, the possibility to use monocytes, with excellent ability to infiltrate the abnormal tumoural tissue, to deliver chemotherapeutic drugs into the tumour has been hardly explored.Here, we aim to use the host monocyte/macrophage cells, with high ability to infiltrate the tumoural tissues, to deliver nano-chemotherapeutic formulations into the bulk of the tumour. We will develop Nano-Formulations consisting in Hyaluronic Acid (HA) nanostructures decorated with beta-glucans, allowing the targeting of specific receptors on the host circulating monocytes (Dectin-1), and at the same time, the loading of chemotherapeutic drugs into these cells. Cytotoxic drugs inducing immunogenic cell death (i.e. bortezomib), and thus the recruitment of new monocytes, will be used to enhance the efficacy of the therapy. Overall, we will use Monocytes loaded with Nano-ChemoTherapeutic Formulations (MNCTFs) as a new strategy to deliver cytotoxic drugs towards the tumoural cells, taking advantage of the infiltration ability of the monocytes/macrophages into tumour microenvironment. The MNCTFs will be tested using appropriate