RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Heterostructure-defined electron waveguides for quantum-based switching applications' (Q-SWITCH), addressing dissemination and exploitation.

assistant: **Impact**

This project is divided into two phases. Firstly the assessment period during which we will consolidate crucial lithography, etching and growth technologies by fabricating samples containing quantum-point contacts with characteristic dimensions less than 40 nm. The systems for evaluation will be overgrown and gated AlGaAs/GaAs and InGaAs/InP samples. We expect coherent transport to be observed in the test systems at temperatures above 4 K, i.e. at temperatures above that of liquid helium. This would indicate a potential for much higher operating temperatures in the devices, based on the assessed technology, that would be fabricated during phase two.The focus of this proposal is on the realisation of transport by coherent electron waves in channels defined by regrown semiconductor heterointerfaces. Quantum interference phenomena will govern the functionality of the proposed types of devices. By introducing large lateral quantization, operation at elevated temperatures would be possible.The quantum electron device has the potential of radically changing present circuit concepts. Such devices operate with active areas of nm-scale dimensions. Packing densities will be high, with extremely high maximum rates of information transfer. Electron coherence has so far normally only been observed at temperatures well below that of liquid helium, due to small characteristic quantization energies for the electron states, as determined by sample architecture. By using semiconductor alloy heterostructures of nm-scale to define potentials vertically as well as laterally it may become possible, with some refinement of technology, to achieve laterally confined electron states with characteristic energy spacings large enough for operation at room temperature. This would transform electron
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The spatial organization of gene regulation in embryonic development.' (OGRE) under Horizon Europe.

assistant: **Objectives**

Master transcription factors (TFs) cooperate with chromatin in regulating genomic activity in animal development and stress response. Local clustering of TFs into dense, sub-micrometer size condensates is emerging as a key feature of transcriptional regulation. This includes intranuclear condensates formed by pioneer TFs during development, transient clusters of RNA Polymerase II complex and nuclear stress bodies formed during a heat shock. Despite the ubiquity of these assemblies, we know little about the biophysical mechanism of their formation or physiological function. The last years have seen the development of new frameworks to study such transient assemblies, including various types of phase transitions and tools to probe and modulate them. However, this work has been limited mainly to cell culture and in vitro experiments that failed to incorporate the vital role of chromatin in organizing gene regulation. I propose a cross-disciplinary strategy consisting of a novel in vitro assays and functional studies in a nematode Caenorhabditis elegans to study the spatial organization of transcription in embryonic development and stress response. The specific aims are:1. Understand the physiological relevance of transcriptional condensates in animal development and stress response.2. Determine the molecular composition and regulators of transcriptional condensates. 3. Dissect the mechanism of transcriptional condensate formation using a novel chromatin carpet assay. We will use state-of-the-art microscopy-based tools to investigate the formation and function of nuclear condensates in developing animal embryos and develop innovative assays to probe the condensation of TFs on the surface of purified native chromatin. The obtained results will provide an unprecedented insigh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural characterization of TFIIIB and its involvement in RNA Pol III transcription' (2007-2013).

assistant: **Concept**

Gene transcription is a highly regulated process that allows cells to adapt during different stages of development and to changes in their environmental conditions. Specifically, RNA polymerase (Pol) III is responsible for the transcription of small, untranslated genes involved in fundamental cellular process such as mRNA processing (U6 snRNA) and translation (tRNAs). Recruitment of Pol III to its transcription start site requires the general transcription factor IIIB (TFIIIB), in mammals a known target of regulation by oncogenes and tumour suppressors. TFIIIB comprises three subunits, (TBP, Brf1 and Bdp1, Mr = 162 kDa) and, despite its crucial role in Pol III transcription initiation and its involvement in cancer cell proliferation, only limited structural information is available for this factor.The project aims to reconstitute and to structurally describe the TFIIIB complex using biochemical and structural biology approaches and to characterize interactions between TFIIIB and Pol III using a combination of X-ray crystallography and single-particle electron microscopy. Description of the architecture of individual TFIIIB subunits, the entire TFIIIB complex, or a TFIIIB/Pol III complex, will contribute to improve our understanding of Pol III recruitment and Pol III transcription initiation. Furthermore, it will provide a structural framework to further elucidate the role of TFIIIB in Pol III misregulation and cancerogenesis.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Adaptations of the ATP synthesis machinery in bacteria and archaea to conditions of extremeenergy limitation in the deep subsurface'.

assistant: **Objectives**

Microbes in the deep sub-seafloor have recently been found to survive under unprecedented conditions of extreme energy limitation. I aim to identify microbes in these deep subsurface communities with central energy metabolism that is adapted to these conditions. A combination of single-cell genomics and metagenomics will be used to identify members of the microbial community adapted to low energy flux by use of Na+-based chemiosmotic ATP synthesis. Following sequencing, genes encoding c subunits of the ATP synthase from the deep subsurface will be synthesized and expressed in E. coli to determine ATP synthase c ring stoichiometry. This project represents a novel approach to microbial ecology and physiology in energy-limited environments with a framework that combines state-of-the-art biogeochemistry, molecular microbial ecology, and biochemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Intelligent Synthesis and Real-tIme Response using Massive Streaming of Heterogeneous Data' in the context of a Seventh Framework call.

assistant: **Objectives**

The instrumentation of the world with diverse sensors, smart phones, and social networks acquires exascale data that offer the potential of enhanced science and services. In particular, a better societal management of the overall cycle of disaster monitoring and response becomes possible, citizens may now become involved in decision making and data acquisition (crowd-sourcing), and advanced planning can conserve resources.Current systems are limited in three important elements: (i) lack of methods for handling heterogeneous data streams in real-time,(ii) absence of social computing integrated with big data analysis, (iii) real-time prediction and alarm capabilities have not yet been incorporated into the infrastructure for intelligent management.The goal of the INSIGHT project is to radically advance our ability of copying with emergency situations in Smartcities by developing innovative technologies, methodologies and systems that will put new capabilities in the hands of disaster planners and city personnel to improve emergency planning and responseIt brings together a strong group of researchers with domain experts in three representative case studies of urban transportation, flood management, and emergency response. A large collection of data sets of different types ranging from Twitter to Traffic Flow Sensing and Mobile Phone Data are available and in use by the project partners Dublin City Council, German Federal Office of Disaster Assistance BBK, Fraunhofer, University of Athens and Technion. Their value will be enhanced by data analysis and data fusion. Geographically and socially correlated aspects will be taken into account by novel methods for streams, parallel data handling (Hadoop, GPUs), and data analysis. Data will be enriched by pro-active social computi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cultural Approach of Radical Islamism in the Context of European Pluralism: Radical versus Moderate Muslims' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The radical Islamism is often presented in the political debate through the prism of religion or geopolitics. Following March 11, 2004 Madrid attacks the European commission has, for the first time, assumed this phenomenon to be the expression of the problem of radicalisation. Moreover, this phenomenon is analysed in the global strategic debate without taking into account the anthropological knowledge of the radicalisation at the local and national levels. Our project consists in filling this gap by leading an empirical, innovative and independent study of the cultural process of Islamist radicalisation in Europe. The Islamist radicalization is presented in the numerous studies in social sciences as the revival or the continuity of the ancient Islamic tradition or of the classical Islamic religious. We intend to confront in the empirical way the cultural tradition and the Islamism. The radicalisation expresses itself by excluding the other, including the non radical Muslims. For us, this phenomenon arises the political question of alterity and ethnicity. Iterdisciplinary our research project arises in the field the question of the emergence, in the democratic political contexts, of the new political forms of dissidence in cases of Moderates and Radicals Muslims in Spain, France and United-Kingdom.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Distributed Optimization Beyond Worst-Case Topologies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Modern systems are increasingly dezentralized and massively distributed computations play a vital role in the systems of the future. This project aims to advance the foundational aspects of distributed computing, particularly MessagePassing algorithms for optimization problems. The strong shift towards distributed systems also lead to a flurry of works on such algorithms -- many optimization problems now have distributed algorithms with optimal worst-case performance guarantees. Generally, these guarantees cannot be improved because they match unconditional impossibility results, which prove severe limitations on the performance of distributed algorithms in some (pathological) network topologies. Real world networks, however, are never worst-case and do not share the limiting bottleneck characteristics of these pathological topologies. In fact, there is no known barrier for ultra-fast polylogarithmic-round distributed algorithms on any network of interest. This leaves an exponential gap between current worst-case-optimal algorithms and what is likely possible in many, if not all, real-world settings.Motivated by this, this project provides a program for a general toolbox and theory for MessagePassing optimization algorithms that go beyond worst-case topologies. The main and guiding high-risk high-gain goal is the development of universally optimal distributed algorithms, which are competitive with the best algorithm on any given topology. This would constitute the strongest possible form of algorithmically adjusting to non-worst-case topologies. A detailed program with many concrete and smaller stepping stones towards this ambitious breakthrough objective is provided. Many of the novel questions stemming from this program and proposal are highly interdisciplinary, cross
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Non-contact electromagnetic direct drives for IP65 food processing and packaging environments'.

assistant: **Innovation**

The project is for the research of non-contact electromagnetic linear drives for the food industry . Automation is now an essential element within food processing and packaging, however conventional drives used for providing automation product particulate contamination through the action of their mechanisms. It is intended to research a viable alternative form of non-contact drive for food handling using direct thrust to overcome this fundamental drawback, as well as enhancing overall speed, reliability and therefore productivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Promoting and linking Wood Industry and Research in Romanian Regions using good practice from acknowledged wood clusters in the EU' in the context of a Seventh Framework call.

assistant: **Objectives**

PRO-WOOD is a project designed to support an emerging wood cluster in the County of Brasov-Covasna in Romania. The wood sector has a long tradition in business and R&D, and an economic potential that needs to be developed. A very successful tool to trigger such economic and knowledge-based environments are cluster initiatives (CIs). However CIs do not have a long tradition in Eastern European, so called transition countries. Therefore it is the challenge of PRO-WOOD to initiate a know how-transfer in order to structure the existing cluster elements. The know how-transfer will be based upon a fact finding analysis and will be harmonized with the special needs of the wood sector in Brasov-Covasna. The project resolves to achieve four objectives:  (1) Establish an infrastructure for regular co-operation between the stakeholders of the wood sector in Brasov-Covasna.  (2) Trigger and increase the role of R&D within the future cluster work.  (3) Formulate a vision for the wood cluster, that indicates objectives and measurable results.  (4) Release a web-based network platform.  Beside the economic effects that an established wood cluster will have for the region Brasov-Covasna, it will support the integration of the region into the European Research Area. Eight partners from Romania, Finland, France and Germany have formed a consortium. This partnership comprises the needed stakeholders on the Romanian side and the knowledge about cluster policy tools, wood research and business on the other side.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Population genetic structuring of cephalopods along the North Western African coast' to be submitted under Fifth Framework.

assistant: **Abstract**

Octopus (Octopus vulgaris) and cuttlefih (Sepia hierredda) are economically important cephalopod species. It is important for fisheries management strategies to identify extent of structuring among Populations along the North Western African coast. Dispersal of octopus, and cuttlefish is via pelagic juveniles, determined by oceanographic features at time of emergence. It is not possible to physically tag paralarvae, however molecular genetic markers would make an excellent tool to examine micro-oceanographic processes affecting their migration.Newly developed microsatellite DNA markers (developed during FAIR CT 1520) will be used to address questions about stock identification of octopus and cuttlefish populations along the North Western African coast. Results from this project indicated significant genetic structuring among octopus populations from Western Sahara and Mauritania, and in Mediterranean cuttlefish.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Aircraft Environmental Impacts and Certification Criteria' (AEROCERT), addressing dissemination and exploitation.

assistant: **Impact**

AEROCERT describes the research items to provide options for improvement of the certification standards, and recommendations for preferred options related to aircraft environmental impact.The key objectives and principal tasks are:I. To identify necessary revisions and/or extensions of the emission certification procedures.a. To identify the known and possible impacts of aircraft emissions on the environment and to identify the data needed to quantify these impacts.b. To define possible indices showing the actual impact of aircraft emissions on the environment or usable to quantify the actual impact on the environment.c. To identify whether the existing certification procedures reflect the impact on the environment, considering different influences such as flight procedures.d. To define options for possible improvements by changing standards and procedures or by extending them, considering the technical feasibility, effectiveness and economic impact of the proposed improvements.II. To identify the effect of operational and maintenance procedures on the certified emission levels.e. To identify the influence of the deterioration in the emission levels of engine and aircraft and to characterise the deterioration in noise and emission levels.f. To make recommendations on operational and maintenance procedures to keep near to the certification levels.Links with other projects, tasks, areas, programmes, policy actions:AERONETICAO/CAEP Committee on Aviation and Environmental Protection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nuclear organisation in the regulation of Hox gene clusters' (NORHC), addressing dissemination and exploitation.

assistant: **Impact**

The correct temporal and spatial patterns of gene expression of Hox genes are necessary for patterning of the developing embryo. Intriguingly, the time and place of Hox gene expression is collinear with the order of the genes on the chromosome. However, t he molecular mechanisms underlying this exquisite gene regulation are poorly understood. In cell culture, the sequential activation of mouse HoxB genes correlates with a visible unfolding of chromatin structure, and a re-localisation of active genes within the nucleus. I want to understand the mechanisms that underpin these large-scale changes in chromatin and nuclear organisation, by combining fluorescence in situ hybridisation (FISH) with mouse models of Hox gene regulation. To do this I will firstly identify cis-acting genomic elements that regulate the nuclear reorganisation of HoxB. I also propose to ask whether other Hox clusters behave similarly, by analysing the nuclear behaviour of HoxD in vivo, in the embryo. These experiments should provide mechanistic insight into colinear gene expression.