RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Algorithms for Structural Variation Analysis in Challenging Genomic Regions' in the context of a Horizon Europe call.

assistant: **Objectives**

Structural variations are genomic alterations affecting portions of the chromosomes longer than 50 base pairs. These alterations are a main contributing factor to human diseases and different types of cancer. The main limitation of current approaches for the analysis of structural variations lies in their unreliability in characterizing these alterations in repetitive and hard-to-call regions of the genome. Structural variations falling in these regions can not be routinely detected and their significance is still unknown.In this proposal, we aim to develop novel computational approaches to address the challenge of fully characterizing structural variations in these hard and still uninvestigated regions. By developing accurate tools for comprehensive detection of structural variations, we aim to increase our current knowledge of this class of genetic alterations. Moreover, by designing new benchmarking methodologies, we will provide a more accurate evaluation of our as well as other tools. This will also assist the development of new generations of tools able to accurately characterize structural variations that are currently unknown.We will employ a multi-faceted strategy that is not limited to a single sequencing technology. By combining data coming from different sequencing technologies and ideas coming from alignment-based, assembly-based, mapping-free, and pangenomic-based approaches, we will be able to take a significant step towards the complete characterization and analysis of structural variations.The development of new tools and the planned collaboration with biology-oriented research groups will enhance our understanding of the impact of structural variations on human health, diseases, and cancer and hence improve clinical diagnostics and pave the way for per
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The evolution of linguistic complexity'.

assistant: **Concept**

Human language is unique among the communication systems of the natural world, providing our species with an incredibly flexible and powerful open-ended system of communication. This expressive power is underpinned by linguistic structure: we construct complex meaning-bearing utterances according to a set of rules and regularities which are conventionalised among speakers of a language. In my previous work I have shown that these fundamental structural features of language can be explained as a consequence of cultural evolution: structure evolves gradually as language is passed down through generations via learning and shaped by its repeated use for communication, in a process known as iterated learning.  However, existing modelling and experimental treatments of iterated learning are limited in that they focus on the evolution of simple languages which permit expression of a relatively small and fixed set of concepts. Real human languages are enormously complex, both in the expressive power they afford and the rich and complex set of structural devices they provide for conveying meaning. In this project I seek to address this major outstanding question in evolutionary linguistics: why is language complex? I will tackle this daunting question by exploring two subsidiary questions: when and how does linguistic complexity facilitate acquisition, and how do expressive power and linguistic complexity evolve as a result of language transmission and use? Answering these questions will require an ambitious programme of modelling and experimental work, covering acquisition in individual adults and children, language use in interaction, and language evolution in populations. I seek to substantially advance our understanding of the cultural evolution of language by exploring how
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '“Multilayer approach for solid-state batteries” - (ROCHE)' (ROCHE) targeting Horizon 2020.

assistant: **Abstract**

Solid-state batteries can surpass the current Li-ion technology in terms of energy density, battery safety, specific power, as well as fast-charging capability. According to H2020 Work programme, give support to the development of next-generation batteries is a high priority. For that, ROCHE project drives to novel cross-disciplinary approaches empowered by digital technologies that can accelerate research on the next generations of safe and high-performing batteries. In this context, the project presents three main goals: (a) to train the talented young researcher Dr. Manuel Salado, in the design, development and optimisation of solid-state electrolytes (SSEs); (b) to assemble those SSEs in a battery using a multilayer approach, and (c) to understand the role of interfaces in the ionic transport in order to unravel a possible kinetic mechanism in solid-state batteries. The combination of different materials together with theoretical calculations envisage not only improve the cutting-edge technology of solid-state energy storage obtain a fundamental understanding of the layered structures containing ionic conductors and IL-MOF related materials. During his short research career, the fellow has gained expertise in the fabrication of nanostructured materials, acquiring hands-on experience with both structural and optoelectronic characterization techniques. Nonetheless, to further boost his career, the fellow needs to broaden his knowledge in the field of energy-storage at Deakin University (DU), as well as to complement the already known characterization techniques with new ones present at Lusorecursos SA. The training program includes learning the use of in-situ characterization techniques and the introduction to simulation techniques in order to extract a kinetic mechan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Demonstrating synergies in combined natural and engineered processes for water treatment systems' to be submitted under Horizon 2020.

assistant: **Abstract**

The AquaNES project will catalyse innovations in water and wastewater treatment processes and management through improved combinations of natural and engineered components. Among the demonstrated solutions are natural treatment processes such as bank filtration (BF), managed aquifer recharge (MAR) and constructed wetlands (CW) plus engineered pre- and post-treatment options. The project focuses on 13 demonstration sites in Europe, India and Israel covering a repre-sentative range of regional, climatic, and hydrogeological conditions in which different combined natural-engineered treatment systems (cNES) will be demonstrated through active collaboration of knowledge and technology providers, water utilities and end-users. Our specific objectives are • to demonstrate the benefits of post-treatment options such as membranes, activated carbon and ozonation after bank filtration for the production of safe drinking water • to validate the treatment and storage capacity of soil-aquifer systems in combination with  oxidative pre-treatments • to demonstrate the combination of constructed wetlands with different technical post- or pre-treatment options (ozone or bioreactor systems) as a wastewater treatment option• to evidence reductions in operating costs and energy consumption• to test a robust risk assessment framework for cNES• to deliver design guidance for cNES informed by industrial or near-industrial scale expe-riences• to identify and profile new market opportunities in Europe and overseas for cNESThe AquaNES project will demonstrate combined natural-engineered treatment systems as sus-tainable adaptations to issues such as water scarcity, excess water in cities and micro-pollutants in the water cycle. It will thus have impact across the EIP Water’s thematic priorities a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Trends in City Expansion and Transport: the Non-Sustainability of Exurbia'.

assistant: **Objectives**

Cities are expanding outwards in an unsustainable fashion. Urban sprawl is a phenomenon that is becoming increasingly evident at the fringes of cities of the developed world. The transportation required to support such low-density extra-urban habitation requires vast energy consumption and produces very high level of greenhouse gas emissions. This level of transport consumption both for personal mobility and for freight movements (including urban deliveries) runs contrary to global and European policies regarding emissions and energy reduction.The level of increase in overall transport movement in the exurbia of cities remains unknown. This project aims to fill in that gap and address policies that could mitigate its uncontrolled expansion.Although there is a recognition of the growing pace and level of exurbanisation, there is dearth of information and hard data on the level of exurbanisation and the associated transport movement.This project aims to fill that gap by not only providing up-to-date data on transport movements in the periphery of large cities but also demographic and transport trend data for four of the world’s major metropolises, London, New York, Paris and Tokyo. This data will be compared to available regional demographic and transport data in Europe. Furthermore using innovative techniques of backcasting that have been largely pioneered (extended and modified) for transportation at the Transport Studies Unit of Oxford University, it will be possible to relate this both to transport and regional planning policies.An objective will be not only to publish innovative academic research but also involve the cities and regions in the understanding and promotion of more environmentally sustainable human urban habitats. Overall, the project will aim to reach o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cell and gene therapy approaches for inherited diseases with unsatisfying or no therapeutic option' to be submitted under Seventh Framework.

assistant: **Abstract**

We have developed the tools and experimental models and have provided the proof of principle that gene modified autologous haematopoietic stem cells can restore a complete immunological system in vivo in a particular form of SCID. We are pursuing these efforts applying this strategy to several other diseases : two lentivirus protocols for X-linked adrenoleukodystrophy, Thalassemia and sickle cell disease, are developed in our Clinical Investigation Centre. In 2010, we plan to initiate two other gene therapy trials for two primary immunodeficiencies (SCID-X1 and Wiskott-Aldrich syndrome). Our expertise in translational medicine has now been used to transfer into clinics a new gene therapy protocol for a devastating  inherited skin disease : dystrophic epidermolysis bullosa. To complement these approaches, we optimize HLA-mismatched haematopoietic stem cell transplantation (HSCT). They are an important therapeutic option for children with primary immunodeficiencies but the delayed reconstitution of the T-cell compartment following T-cell depleted HSCT remains a major clinical concern thus drastically limiting its broader clinical application. In order to speed-up the immunological reconstitution in this setting, we try to pre-clinically develop a new approach able to generate a large quantity of T-cellular precursors from a fraction of the donor CD34+ stem cells shortly cultured on Notch delta 4 ligand. This strategy could ideally provide the recipient with a pool of diverse T-cells within the first month after transplantation conferring T-cellular immunity before de novo thymopoiesis takes place.The results obtained with this procedure are so important that we think to extend its use to the transduction of HSC for the gene therapy trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Robotic Orbital Support Services', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

EROSS (European Robotic Orbital Support Services) objective is to demonstrate the European solutions for the Servicers and the Serviced LEO/GEO satellites, enabling a large range of efficient and safe orbital support services. The project will assess and demonstrate the capability of the on-orbit servicing spacecraft (chaser) to perform rendezvous, capturing, grasping, berthing and manipulating of a collaborative client satellite (target) provisioned for servicing operations including refuelling and payload transfer/replacement. EROSS embeds key European Technologies by leveraging on actuators, sensors, software frameworks and algorithms developed in previous European Projects. EROSS boosts the maturity of these key building blocks and increases their functionalities and performance in a coherent work programme targeting fast and practical deployment of the developed solutions in space. The consortium went into great details in the EROSS concept and the technical operational plan to manage perfectly the risks and complexity of development of such a large system. Following EROSS, TAS plans to commercialize its Multi-Purpose Servicing Chaser in 2021 for the LEO&GEO servicing business, pulling with him the project’s technology providers. Besides, most partners will address other short-term space/non-space markets, such as Space Exploration & Science and factory automation (sensors, robots).The project success relies on a highly skilled and experienced consortium involving all the leaders of previous SRC Operational Grants. EROSS involves 11 partners from 8 countries over 24 months and a budget of 3,9M€. As Operational Grant n°7, EROSS will be part of the Strategic Research Cluster (SRC) on Space Robotics.


**Keywords:** servicing spacecraft, refueling, payload, orbital tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Signatures in Anthropological SOILs: Developments for the identification of activities associated with daily life' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

If the human uses of soils are profoundly different, can these use histories be deduced from their chemical traces? Using the potential of organic biomarkers, AnthroSOIL will assess spatial organisation of prehistoric dwellings in order to recognise daily life activities through soil organic matter analysis. At the interface of archaeology and chemistry, the project aims to develop a new methodological approach for the organic analysis of palaeosoils. State-of-the-art methods and cutting edge technology in organic residue analysis will be assessed and used to characterise and to map the organic content of soil (elemental analysis, PyGC & ultrafast-GC, LC-MS/MS, GC-MS/MS, GC-c-IRMS, MALDI imaging, ZooMS, starch analysis).The project will investigate activity patterns within Stonehenge World Heritage site by an extensive study of the Late Neolithic settlement of Durrington Walls a short-lived but large village probably inhabited by the builders of Stonehenge. Durrington Walls present a unique opportunity to examine activities across one of Europe’s finest and most well excavated prehistoric sites.The project will benefit of a remarkable concentration of expertise at the University of York (UK), within BioArch, an inter-disciplinary research centre dedicated to work on biomolecular archaeology, an emerging European research strength. I will work in state-of-the art facilities with world-leading scientists in bioarchaeology for the joint development of archaeological soil studies. The broadening of my skills and perspectives through the combination of a broad range of analytical techniques in lipids, proteomic and stable isotopic to study prehistoric daily life, will place me in an excellent position to exploit new opportunities in biomolecular archaeology research and enha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modes of large RNA loop stabilization - towards more efficient Molecular Dynamics protocols' (2002-2006).

assistant: **Innovation**

Apical loops of at least six nucleotide residues are often distinguished by a cross-loop base pair leaving three nucleotides at the cap of the loop forming a well conserved motif called T-loop or lonepair triloop. Our previous studies have indicated the occurrence of such a loop pattern in the HIV-1 TAR RNA. The present project concerns molecular structure and dynamics of sequence-dependent modes of large loop stabilisation. We will focus on apical loop of the dimer initiation site (DIS) of the leader sequence of HIV-2 RNA, composed of 11-nucleotide residues and including a palindromic sequence. We suppose that prior to its involvement into loop-loop interaction via kissing hairpin mode, the HIV-2 DIS RNA hairpin undergoes intra-loop stabilisation.Advanced molecular dynamics simulation techniques will be used in order to get an insight into the structure and dynamics of this model. In addition, possible contribution of magnesium cations to the loop stabilisation will be investigated by combined Brownian Dynamics/MD methods. The Molecular Dynamics Thermocycler protocol, recently proposed by us, will be simultaneously developed and applied for the project. At the level of conformational analysis, novel methods for description of the conformational space of the loops will be proposed, based on the cluster analysis approach. In order to confront our simulations results with physical data, the RNA models will also be chemically synthesised and their melting thermodynamics will be studied based on magnesium dependence. The picture of RNA/magnesium binding sites emerging from simulations will be confronted with results of Mg2+ ion-promoted RNA cleavages studied by electrophoresis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Unpacking confined lives: Generating a global research agenda on the intersection of urban marginality, displacement, and incarceration', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

CONFINED will develop and validate an innovative, comparative, and global research agenda of confined lives. Confinement is a ubiquitous and unequally distributed human condition. While confinement sometimes can be protective, for some groups, not least the displaced on dangerous roads, the marginalized in urban slums and the detained in prisons, it can be a damaging experience linked to violence and inequality. With an empirical point of departure in different contexts across the global north and south, known to produce a variety of confined lives, CONFINED explores, 1) how certain peoples lives are rendered confineable; 2) how confineable groups and networks navigate discursive, actual, and potential practices of confinement, and 3) how and to what extent the concept of confined lives can transform our understanding of the practices and experiences of confinement across global divides in ways that drive theoretical innovation and help build new agendas for social justice. Through three interdependent and sequentially organized work packages, CONFINED proposes to explore confined lives contextually and ethnographically across the global North and South (WP1); to compare what confines people, how they make sense of their confined lives, and how they navigate confinement (WP2), and to conceptually develop and validate the approach through engagement with academics and experts locally and globally (WP3). CONFINED will carry out comparative, ethnographic field work to follow precariously situated translocal family network across four contexts as a privileged lens to understanding confined lives at the intersection of dangerous journeys, urban slums and prisons and camps: Denmark and Lebanon; South Africa and Malawi; Thailand and Myanmar and the UK and Sierra Leone. This wi