RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Legumes for silage in low input systems of animal production: appraisal and demonstration of results and technologies.' under Fifth Framework.

assistant: **Concept**

The need for improved and sustainable- systems of land use and animal production is highlighted in FP5. Forage legumes have a potential for improving sustainability by reducing requirements for fertilisers and concentrate feeds, but have been little adopted in northern Europe. A multi-disciplinary project in FP4 (LEGSIL) has made much progress in providing a sound technical basis for the use of forage legumes in that area. The objective of the proposal is to achieve rapid evaluation and dissemination of the results of LEGSIL through northern Europe. This will be achieved by holding a Workshop involving invited experts from throughout the region with its subsequent publication and the production of booklets targeted to farmers and advisors in different parts of northern Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cartilage progenitor cells for growth plate regeneration' (Grolaries) targeting Horizon 2020.

assistant: **Abstract**

Growth plate injuries result in growth arrest, formation of a “bony bar” and angular limb deformities in children. Novel therapeutic approaches directed towards prevention of bone formation and growth arrest have to integrate cellular grafts, biomaterials and growth factors with the ultimate goal of recapitulating the complex zonal organization of the growth plate. One endogenous source of cartilage progenitor cells is thought to be the resting zone of the growth plate. Until now, the lack of specific marker(s) for the resting zone restricted the examination of this population. In the proposed research, I aim to label and trace these cells during postnatal growth and in reaction to trauma, and I aim to understand: whether resting zone cells express skeletal stem cells characteristics (Aim 1), whether they are expandable and multi-potent (Aim 2) and whether they contribute to regeneration of the growth plate in a physeal fracture model (Aim 3). Clinical translation of chondrocyte stem cell regeneration necessitates basic validation in human tissue of the cell surface markers found in mouse stem cells. This last step in the project will be performed in collaboration with Dr. Fernando Santos Laboratory at University of Oviedo, Spain. Altogether, these results will provide a strong basis for development of bioengineering strategies for growth plate cartilage restoration. Finally, this collaboration between Dr Andreia Ionescu Lab and Dr Laboratory would provide not only an interchange between American and European laboratories, basic and clinical science, but also a robust criterion for identification of a stem cell population instrumental for the development of future therapeutics.


**Keywords:** Growth plate, Stem Cell, Regeneration, Mouse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coordination Action Carbon Observation System', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

COCOS will assess the status of harmonization of key carbon cycle variables with international partners. It will improve the interoperability of data sets that are used in global scale carbon cycle studies through joint activities between ecosystem, atmospheric and ocean bottom-up and top down observation communities. COCOS will also perform integrated regional-scale multiple constraint assessments of the land and ocean carbon balance through the use of harmonized data sets. It will identify, narrow down uncertainties and decrease differences in emerging global data sets that are aimed at providing constraints on the vulnerability of the global carbon cycle. COCOS will thus contribute to the implementation and improvement of global observing systems. It will organize a large international conference to demonstrate the status and way ahead of global carbon observations in light of monitoring requirements for GEO and the implementation of future climate change mitigation commitments.  As such, it will contribute to an effective monitoring of the carbon cycle at global level as recommended by GEO and GCOS in supporting the European participation to an international CO2 research monitoring project. The research and harmonization work developed in this proposal will contribute significantly to building an integrated global approach that promotes close collaboration with the international carbon cycle research community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ecc '99' under Fifth Framework.

assistant: **Concept**

The European Control Conference is organised every 2 years under the auspices of the European Union Control Association (EUCA) in co-operation with IFAC and in collaboration with the IEEE Control Systems Society. It takes place in one of the member countries of the European Union and aims to stimulate contact between specialists active in academic research and industrial development in the area of advanced control strategies and to promote scientific exchange within the European Community and between Europe and other parts of the world.The conference provides an excellent opportunity especially for young researchers such as graduate, doctoral and post-doctoral students to present their scientific work to an international audience, to learn about state-of-the-art topics and to engage into discussions with highly reputed researchers from academia and industry. Female researchers were especially encouraged to participate by the organisers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The emerging role of TARGET OF RAPAMYCIN in regulating the shade-induced pathogen susceptibility in plants' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

In close proximity, plants can sense each others presence via a decrease in the red to far-red light ratio (low R:FR) in the nearby surroundings. Low R:FR perception by phytochrome photoreceptors triggers strong and rapid elongation growth allowing plants to grow taller than their neighbors and reach better lit areas. This process, known as shade avoidance is mostly orchestrated by the growth hormone auxin. However, although low R:FR promotes elongation growth, it compromises plant defense against pathogens by dampening defense hormone signaling; a phenomenon referred to as shade-induced susceptibility. Furthermore, I recently found that plants exposed to low R:FR conditions accumulate glucose, which accelerates pathogen development in plants tissue. Yet, the involvement of primary metabolism in regulating the shade-induced susceptibility remains to be explored. In eukaryotes, the TARGET OF RAPAMYCIN (TOR) kinase is a master growth regulator integrating the cell energy and carbohydrate status to regulate growth and defense responses. In plants, TOR activity is promoted by auxin and glucose, both strongly induced by low R:FR. Interestingly, I also found TOR gene expression to be induced by low R:FR in a recent RNA-seq study. In this project, I will study if and how low R:FR regulates TOR signaling to promote growth at the expense of defence. I will use genetic and chemical approaches to (I) identify the spatiotemporal dynamics of TOR gene expression and TOR protein activity in response to shade in the model plant Arabidopsis thaliana, (II) identify the dependency of shade-induced auxin levels and sugar accumulation on TOR dynamics and (III) characterize potential links between TOR signaling and defense hormone signaling. The gained insights will be instrumental for under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms underlying regulation and removal of G-quadruplex/R-loop transcription-replication conflicts', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Maintenance of genome stability is challenged by obstacles that interfere with normal progression of essential DNA-associated transactions, such as DNA replication and transcription. One such obstacle is the G-quadruplex (G4) DNA secondary structure, which can form in G-rich repetitive DNA sequences. Transcribed G4-DNA loci often co-exist with stable RNA-DNA hybrids (R-loops), potentially causing deleterious transcription-replication conflicts (TRCs). Therefore, the ability of cells to mitigate TRCs formation is critical for cell and organismal fitness. While the pathways involved in repairing other DNA lesions are relatively well understood, the mechanisms by which cells respond to G4/R-loop-induced TRCs remain uncharted, largely due to a lack of efficient approaches for inducing site-specific G4s/R-loops into the genome. Several studies reported dedicated helicases capable of unwinding G4s/R-loops, yet whether additional factors exist and how different types of TRCs are resolved remains unknown. In this project, I aim to dissect the fundamental mechanisms that protect cells from TRCs at DNA loci harbouring G4s/R-loops. To do so, I will establish a novel system with site-specific G4/R-loop substrates in living cells and I will systematically investigate their protein composition to identify novel factors in G4/R-loop metabolism. I will further examine the genetic vulnerabilities of candidate G4/R-loop helicase-deficient cells and the regulatory mechanisms underlying G4/R-loop unwinding by these helicases. As mutations in several G4/R-loop helicases predispose to various cancers and genetic disorders, a detailed understanding of the basic mechanisms controlling G4/R-loop removal is of utmost importance, and will shed light on disease aetiology and the rational developme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Development of strategies for control and prevention of antibiotic resistance in european hospitals (ARPAC)'.

assistant: **Innovation**

This multidisciplinary project aims to understand better the magnitude of antibiotic resistance in human pathogens and to develop strategies to control resistance in European hospitals. This will be done by combining and building upon the expertise of established European projects. The project will gather human antibiotic consumption data; establish antibiotic resistance rates untargeted bacterial pathogens; investigate current guidelines on antibiotic policies and infection control policies and investigate standardisation of methods used to track human resistant pathogens. For the first time, this project will explore the variability of all these individual parameters across a commonest of European hospitals and will model relationships between these consensus conference will define strategies for controlling resistance in hospitals, leading to future intervention trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transcriptome analysis of sulfur starvation in plants' to be submitted under Fifth Framework.

assistant: **Abstract**

The genes involved in the regulation of plant sulphur metabolism during sulphur starvation will be identified using a transcriptomic approach. Up/down regulation of these genes in transgenic plants and subsequent detailed molecular and biochemical analyses should reveal their precise function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Therapeutic hijacking of E3 Ligases' (Glue2Degrade), addressing dissemination and exploitation.

assistant: **Impact**

Traditional drug design relies on inhibition of enzymes or receptors with accessible hydrophobic pockets. The concept of proteolysis targeting chimeras (PROTACs) promised to overcome this limitation. Following our discovery of the first PROTAC that induced selective protein degradation in vivo, this technology has seen a boost in academia and industry. Despite global research efforts, advances are so far incremental: (i) most focus is on degrading targets that can be liganded and are druggable with conventional inhibitors; (ii) currently, only 3 out of 600 E3 ligases can be exploited. Glue2Degrade aims to transform the pharmacologically targetable space of the proteome. The project is built on the hypothesis that molecular glues (MGs), non-chimeric small molecules that degrade target proteins by inducing cooperative binding to E3 ligases, are much more prevalent than anticipated. Lenalidomide and related immunomodulatory drugs (IMiDs) are prime examples of the potential of MGs. Without a specific targeting moiety, IMiDs induce cooperative binding of the E3 ligase CRBN to undruggable proteins like IKZF1/3, thereby inducing their degradation. However, no technologies exist to rationally develop MGs that hijack other E3 ligases.  ERC-funding would allow us to address this limitation. Based on data generated in my laboratory, we will systematically identify novel MGs and their E3 ligases by innovating (i) phenotypic discovery strategies, and (ii) an orthogonal chemical genetics pipeline. To elucidate the mechanisms of novel MGs, we will (iii) conduct target identification via unbiased proteomics followed by (iv) chemical optimization and initial translational characterization. Glue2Degrade, if successful, will transform the engageable E3 space and identify novel MGs, thereb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards a Universal Model for Eutectic Electrolytes in Zinc Batteries by Operando Diagnosis' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The demands of the Paris Agreement mean that we must shift toward a cleaner energy and transportation infrastructure. This requires new energy storage technologies. The rechargeable aqueous zinc battery (AZIB) offers a cheap, sustainable, safe, and high storage capacity solution suitable for complementing the intermittency of renewables, alongside commercial applications spanning transport to flexible ‘smart’ apparel. As a relatively nascent technology, AZIBs unfortunately suffer from fundamental materials chemistry issues, undergoing rapid performance decay over repeated charge/discharge cycles. I am an experienced researcher in eutectic electrolytes, a type of electrolyte with strong interactions between its constituent components, and I believe they can pose a solution to many of the failures that occur in AZIBs. However, understanding the complexity going on inside an operating battery is notoriously difficult, yet doing so is necessary to unlock the fundamental knowledge required for me to design the ideal electrolyte to combat AZIB capacity fade. Working with Dr Robertson at Warwick University, I will learn how to perform advanced insitu characterisation of AZIBs, across X-ray spectroscopy and transmission electron microscopy (TEM), and use them to diagnose these complex processes. This will allow me to design an optimal eutectic electrolyte for AZIBs, which I will then investigate for scale-up feasibility at Warwick’s battery pilot line.My research objectives:-Reveal the role of different eutectic electrolyte compositions on the AZB metal anode.-Diagnose why AZIB cathodes are more robust when cycled with certain eutectic electrolytes-Design a suitable eutectic electrolyte for a full-cell AZIB, taking into account industrial scale-up considerations.Supported by ga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synthesis, characterization and conductivity studies of conducting polymer-DNA hybrids' (POLYCONDNA).

assistant: **Concept**

In this project we propose to develop conducting nanoscale molecular wires based on hybrid polymer materials. The concept is to use DNA as a scaffold for the attachment of polymerisable monomer units covalently bound to the DNA nucleosides. Novel synthetic nucleosides will be prepared for oligomerisation using automated solid phase DNA synthesis. It is intended to synthesise modified nucleosides, in particular the pyrimidines, which can be applied to the sequence specific synthesis of DNA strands. The nucleoside will be modified with units derived from pyrrole and thiophene since these compounds are readily polymerized to conducting materials. In using DNA as a scaffold or backbone the self-assembling properties of DNA may be exploited for the construction of large and complex nanoscale architectures. In this way it should be possible to direct the assembly of nanoscale wiring by using the inherent biological assembly process of the DNA part of the hybrid material.   Established synthetic methodologies will used for the synthesis of the precursor compounds and these will be characterised using standard techniques to establish structural details, e.g. NMR, elemental analysis, ionized electrospray mass spectroscopy LC(IES-MS), spectroscopic (FTIR, UV-vis). The synthesis of DNA oligomers will rely on phosphoramidite chemistry and automated solid phase protocols. The formation of conducting polymer wires will involve oxidation of the resulting DNA-pyrrole/DNA-thiophene strands using chemical and electrochemical approaches. The resulting materials will be characterised using a range of spectroscopies (FTIR, CD, UV-vis) as well as voltammetry and probe microscopy. Finally, the conducting properties of the materials will be examined using a combination of 2-electrode devices a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Comparison and assessment of funding schemes for the development of new activities and investments in environmental technologies' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The project examines funding of environmental technology development and commercialisation. The objectives are to: - measure the performance of existing funding schemes (emphasising commercial-type funding); - determine how environmental aspects are dealt with; - identify obstacles; and - suggest evolution of new schemes. Eight project work packages address these objectives, and also include development of environmental technology typologies, analysis of funding gaps, and comparison to Japan and the US A. The project supports SSP 5A by connecting policy and practice, linking researchers from across the EU, and using wide consultation to disseminate knowledge and maximise exploitation of research results.  Consortium partners are drawn from five EU state s, and have expertise and networks in private and public environmental technology funding and technology development processes. Stakeholder consultation with private and public sponsors, developers, academics, policy makers and NGOs will support research and knowledge dissemination.  Consultation will include major public conferences and forums, sector-specific focus groups, and workshops to test analysis and geographic variations. Consultation and publication and dissemination of the final report will spur innovation by private and public sponsors, supporting knowledge exploitation after project completion. Research will emphasise private sector solutions, but will also include public-private partnerships, which are innovative measures that can assist in closing the funding gap.  The varying applicability of such partnerships across different EU states will also be considered. The two project deliverables will be a database containing research and contact information, and a widely published final report that will integr