RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ramification of braid groups and their related structures' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The proposed project brings together Neha Nanda, a young researcher who finished her Ph.D this summer, and who already has a number of publications and pre-prints, and an experienced researcher, John Guaschi, who is full professor at Universit de Caen Normandie. They propose to study certain ramifications of braid groups and related structures, namely the (virtual) twin groups, and the relations of these groups with (virtual) doodles that play the rle of planar analogues of knots in R^3. The main aims of the project are:1) understand better the (pure) twin groups by studying some of their invariants, such as their virtual cohomological dimension, and look for good presentations for them using Fadell-Neuwirth-like short exact sequences. 2) following the construction of surface braid groups from Artin braid groups, generalise the (pure) twin groups to surface (pure) twin groups, obtain presentations of these groups, and seek doodle-like structures to which they correspond.3) construct new (virtual) doodle invariants, some being analogous to those known for knots and links, the aim being to classify (virtual) doodles.Being at the intersection of several domains, the general setting of the project is active and competitive. As well as being ambitious, the project is innovative, not just for the choice of problems to be studied, but also because its members have complementary interests and skills in algebra, low-dimensional topology, and combinatorial group theory. The project members will also be able to count on the expertise of other mathematicians in Caen working in related areas, as well as the dynamic network of the research group in Caen, including meetings organised by members of the GDR ""Tresses"", the regional ARTIQ project in collaboration with computer scientist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart Fenton OXidation: a catalytic membrane for water purification' under Horizon Europe.

assistant: **Concept**

The main goal of this project is the development of new polymeric catalysts and new catalytic membranes, designed to carry out high-end chemical oxidation in aqueous streams. Catalytic membranes are means to perform chemical transformation at the solid/ fluid interface and they are ideal interfacial reactors and contactors, simultaneously catalyzing and directing the heterogeneous phase reaction between substrates and oxidant agents. These systems have a key role in the future process industry and in water treatment since they enable oxidation reactions whilst reducing reagents and waste. Current systems employ inorganic and often high-value catalysts, which are generally of high cost, and prone to leaching causing loss of performance in time. I propose the first fully polymeric catalytic membrane made exclusively of bio-inspired iron coordination polymers. This research will lead to key scientific breakthroughs by: i) creating new non-heme catalytic polymers that mimic the activity of biological enzymes and that can be efficiently deployed to cast membranes for heterogeneous reaction; ii) designing and fabricating polymeric membranes consisting of the catalytic macromolecules and with suitable surface and morphological properties to precisely guide and enhance the contact among the reagents and with the catalyst; iii) successfully applying these systems maintaining high catalytic rate and yield and to understand the mechanisms and pathways of transformation of compounds, especially water micropollutants. These innovations will enable membrane robustness, long-term efficiency, and low cost. In particular, the potential of the new catalysts, membranes, and membrane reactors will be exemplified in the purification of contaminated streams to produce safe water. Thus, this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Preventing bacillus cereus foodborne poisoning in europe - detecting hazardous strains, tracing contamination routes and proposing criteria for foods.' under Fifth Framework.

assistant: **Concept**

Bacillus cereus is a food borne pathogen, which causes gastroenteritis. Fatal and severe cases have been reported within the last few years. Virulence of B. cereus is only partly understood. Most strains are presumably innocuous or mildly pathogenic whereas few are presumably highly virulent. No methods exist to distinguish virulent from non-virulent strains. The project proposes to investigate virulence mechanisms of B. cereus in order to identify determinants specific of highly virulent strains. From these results, methods to detect virulent strains will be designed and dose response curve will be improved. The diversity of virulence within B. cereus and the ecology of virulent strains will be investigated in order to identify the contamination routes of foods with virulent strains and to estimate the risk for their presence and development infolds.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Role of the chromatin architecture in the regulation of gene transcription'.

assistant: **Innovation**

The complex architecture displayed by the chromatin inside the nucleus of eukaryotic cells plays an important role in several key cellular processes such as the regulation of gene expression, DNA replication and DNA repair. The dynamics of this chromatin architecture remains however poorly characterized. While at “steady state” the chromatin organization is thought to be relatively stable along the entire interphase, dramatic modifications of this architecture has been observed in response to external stimuli. In particular, the activation or repression of gene transcription is often associated with local changes in the level of chromatin compaction and with gene repositioning inside the nucleus. A precise understanding of the mechanism underlying this chromatin reorganization is impeded by the lack of a complete description of the dynamics of the restructuring process.With the “ChromaTranscript” project, the researcher proposes to investigate the process of nuclear restructuring in association to transcriptional activation or repression of estrogen-regulated genes using an original approach at the interface between biology, physics and advanced microscopy. The three following questions will be investigated:1) What is the dynamic of the nuclear reorganization process at the scale of a single chromosome ?2) What are  the changes in the fine chromatin structure underlying the micron-scale nuclear reorganizations studied in 1) ?3) Is nuclear reorganization the cause or the consequence of the change in transcription activity ?The interdisciplinary approach which is proposed in the project combines tagging methods, used to label in fluorescence single chromosome or specific gene loci in living cells, and advanced light microscopy methods allowing the monitoring, at different
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Large-scale, Cross-lingual Trend Mining and Summarisation of Real-time Media Streams' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The recent massive growth in online media and the rise of user-authored content (e.g weblogs, Twitter, Facebook) has lead to challenges of how to access and interpret these strongly multilingual data, in a timely, efficient, and affordable manner. Scientifically, streaming online media pose new challenges, due to their shorter, noisier, and more colloquial nature. Moreover, they form a temporal stream strongly grounded in events and context. Consequently, existing language technologies fall short on accuracy, scalability and portability.The goal of this project is to deliver. innovative, portable open-source real-time methods for cross-lingual mining and summarisation of large-scale stream media.TrendMiner will achieve this through an inter-disciplinary approach, combining deep linguistic methods from text processing, knowledge-based reasoning from web science, machine learning, economics, and political science. No expensive human annotated data will be required due to our use of time-series data (e.g. financial markets, political polls) as a proxy. A key novelty will be weakly supervised machine learning algorithms for automatic discovery of new trends and correlations. Scalability and affordability will be addressed through a cloud-based infrastructure for real-time text mining from stream media.Results will be validated in two high-profile case studies: financial decision support (with analysts, traders, regulators, and economists) and political analysis and monitoring (with politicians, economists, and political journalists).The techniques will be generic with many business applications: business intelligence, customer relations management, community support. The project will also benefit society and ordinary citizens by enabling enhanced access to government data a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Strong field interaction of van der walls clusters with ultrashort laser pulses' under Fourth Framework.

assistant: **Concept**

The study of strong laser-field interaction with simple molecules has been a field of intense research over the past decade. Despite the complexity of the overall process implying both multiple ionization and Coulomb explosion of the molecular ions, the interaction dynamics are now quite well understood. The aim of the present proposal is to extend the study to atomic and molecular clusters. So far, only few but very promising results have been obtained by the group of C.K.Rhodes concerning the multiphoton-induced X-ray generation with rare-gaz clusters and by the group of A.W.Castleman concerning the interaction dynamics of strong laser-field interaction with molecular clusters. We intend to work in this novel, exiting field of molecular physics in the group of D.Normand in Saclay who has access to the high power Ti:sapphire laser facility of the DRECAM and is constructing a new high-resolution mass-spectrometer which allows for studies in supersonic beams.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'TELEMATICS FOR ENTERPRISE REPORTING'.

assistant: **Innovation**

TELER will test a common European model and standards for simplifying data exchange between national statistical institutes and firms. By this means, many different statistical enquiries may be merged into supersurveys, irrespective of accounting practices or the size of firms or industrial sectors. Business accounting or invoicing records built into a national or international classification system, and transmitted along common lines will also result in cheaper data gathering. Project data models, classifications, and software will be standardised for eventual Europe-wide implementation and marketing.TELER aims at demonstrating the feasibility of a common model and related standards for the exchange of data between enterprises and data collectors, especially National Statistical Institutes (NSIs). Both firms and NSIs will benefit from the implementation of this approach as it offers: a/ simplification, e.g. by merging several statistical surveys into one electronic superquestionnaire b/ common standards, by adopting one model, whatever the size of firm, sector of industry, country, accounting practices, etc. c/ gains of work load, as the technologies used will (i) allow to tap electronic data provided by the accounting packages or invoices systems used by the firm (which saves data keying in), (ii) help transcode these data into (inter)national classifications, (iii) provide transmission facilities to send the data with the appropriate structure. The demonstrator is based on (i) a repository or model of data necessary for the data collectors, called BISE; (ii) software modules with facilities of format translation, BISE management, communication, etc. called SISE. BISE is based on data models and standard classifications which will be designed in the project and which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Investigating the anti-apoptotic properties of NleH, an effector of the diarrheagenic pathogens Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC)'.

assistant: **Objectives**

Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic Escherichia coli (EHEC) are closely related diarrheagenic pathogens that are important causes of morbidity and mortality worldwide, especially in young children. EPEC and EHEC are known as attaching and effacing pathogens because they intimately adhere to gut enterocytes and instigate effacement of brush border microvilli. Injection of bacterial effector proteins via a type III secretion system (T3SS) is an integral part of the EPEC and EHEC infection strategy. One such effector, EspF, binds and induces degradation of the anti-apoptotic protein AbcF2, however, although infected cells show early apoptotic symptoms, they do not present late apoptosis signs. The T3SS effectors NleH1 and NleH2 were recently found to have a broad range anti-apoptotic activity which may neutralise the effect of EspF and promote cell survival. In this proposal we wish to investigate the anti-apoptotic activity of NleH, in particular its binding to the endoplasmic reticulum (ER) anti-apoptotic protein Bax inhibitor-1 (BI-1) and to PDZ domain-containing protein/s.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Discovery of content descriptors for documents' (1994-1998).

assistant: **Concept**

Research objectives and content In the project, methods for discovering content descriptors, based on the text of documents, are developed and evaluated. Typical examples of content descriptors are keywords. Representative content descriptors are useful, even required, in many application areas, particularly in information retrieval. Extracting of keywords has been studied for a long time. However, the recent development has changed the situation: the appearance of huge document collections for the use of everyone sets new requirements for the methods. In this project, so-called data mining methods are studied and a special objective is to discover complex, structured content descriptors, e.g., phrases, and evaluate their usability in information retrieval. Training content (objective, benefit and expected impact) The home department has active Data Mining and Document Management research groups, whereas there is no tradition in information retrieval research. Hence, the training in standard and state-of-the-art information retrieval techniques and in conducting experiments is the key benefit. This combined expertise is invaluable to the new, emerging field of data mining in text. Links with industry / industrial relevance (22) The results of the project will be utilized within a project called Structured and Intelligent Documents at the University of Helsinki. The industrial partners of the project include major publishing and media houses in Finland, e.g., Aamulehti Group and Edita.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'A concurrent approach to manufacturing induced part distortion in aerospace components'.

assistant: **Innovation**

COMPACT is to look at manufacturing induced part distortion of aerospace alloy components. It is estimated that tens of millions of Euros are spent every year in an attempt to either avoid or remedy distortion in components. Consequently this is an expens ive problem for the aerospace sector that offers a significant business and intellectual challenge. Part distortion is a function of residual stress and is caused by the complex relationships between material processing, component design and manufacture. The work programme has been developed around these three fundamental streams of research and consequently adopts a truly concurrent approach.Two further research streams will enable the weight of research findings to be effectively applied to problem so lving. These are finite element modelling and knowledge integration. Research will be used to gain a greater degree of understanding across engineering disciplines and create a knowledge base using a process-orientated approach. Finite element modelling will be used to develop three-dimensional functionality that will enable multidisciplinary simulations to be undertaken. The knowledge integration work will use this technology in order to assist or guide cross-functional engineering teams in the decision making process.The work will eventually enable costs savings to be made in manufacturing through the minimisation of 'scrap', rework, concessions and the expensive re-processing of aluminium. Through looking at design in the light of residual stress it is expected that the design work will enable engineers to optimise geometrical shapes and produce lighter components and hence aircraft. This will lead to further savings in manufacturing and the running cost of aircraft. COMPACT offers many opportunities for value and no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mechanical regulation of cellular behaviour in 3D viscoelastic materials' (MECHANOSITY).

assistant: **Concept**

Extracellular matrix (ECM) mechanical properties have emerged as key promoters of processes such as cell migration and epithelial to mesenchymal transition (EMT) in cancer. Despite recent advances in the understanding of cellular ECM sensing machinery, mimicking tissue microenvironments in vitro is highly challenging, and most research has been focused on two dimensional (2D) elastic substrates. However, ECMs are not merely 2D elastic substrates, but rather viscoelastic three dimensional (3D) materials. Our objective is to understand how the viscoelastic properties of 3D ECMs regulate cell behaviour. We hypothesize that in viscoelastic materials, counter-intuitively, an increase in viscosity triggers force transduction and gene expression, due to an increase in the load of molecular clutches formed between the ECM and actin. To address the influence of viscoelasticity, Alberto Elosegui-Artola (the experienced researcher/ Applicant) will develop a set of hydrogels matching the viscoelastic properties of both healthy and malignant breast tissue. Then, traction force microscopy will be developed and combined with molecular biology techniques to determine the molecules involved in 3D viscoelasticity sensing. The dynamic behaviour of these molecules will be integrated in a 3D molecular clutch model with the aim to predict cellular migration and force transduction. Model predictions will be validated by performing experiments in 3D viscoelastic gradients on the migration of single cells and spheroids. Lastly, the relevance of the model will be tested by observing if impairing model-predicted force transduction elements prevents EMT transition in cell lines and mouse-derived breast healthy and tumour organoids. This project’s results are expected to reveal molecular interactio