RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Determination of the complete residual strain tensor by the CBED method' to be submitted under Sixth Framework.

assistant: **Abstract**

Residual stresses influence failure mechanisms in polycrystalline and composite materials and frequently lead to scrapping products. Of all methods of strain determination, the one using transmission electron microscopy and convergent beam electron diffraction (CBED) patterns has by far the best spatial resolution. In the CBED method, strain is obtained by fitting an experimental pattern to a simulated pattern. However, there is a serious problem with the method. It has been shown numerous times that its results are ambiguous. The causes of ambiguities are not understood, and this hinders the development of fully functional systems for strain determination.The problem is addressed by limiting the number of independent strain parameters. The procedures currently used calculate up to three (out of six) parameters. Despite that, strong instabilities of the calculated strain tensor entries are encountered. The scientific objective of the project is to remove the ambiguity in the CBED method and make it capable of providing complete strain tensor. We already know that the influence of some parameters on the differences between simulated and experimental patterns is many orders of magnitude weaker than the effect of other parameters. Thus, the initial step of the project will be the identification of the indeterminable parameters. With indeterminable parameters known, currently used 'educated assumptions' will be replaced by a robust approach.The goal is to create a reliable method of determination of the complete strain tensor based on multiple sample tilts. Computer programs for calculating the tensor based on multiple patterns will be written and extensive tests of the method will be performed. Development of a reliable method will definitely advance the work o n local ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PROMOTION OF INNOVATION MANAGEMENT TECHNIQUES IN THE FIELD OF SUB-CONTRACTING' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Aim of this project is to validate the relevance of a number of methodologies in the development of innovation in SMEs in the field of sub-contracting and to promote this action among national organisations, both public and private helping SMEs.In particular:- Assess the relevance of the innovation approach for the benefits of the sub-contracting sector- Validate the methodologies grouped in blocks forming the structure of an Innovation Consultancy Assignment.The methodologies have been structured as follows:- INNOTEC (global analysis and diagnosis)-.INNOSTRAT (strategy analysis)-.CREATEC (creativity method)- INNOVEIL (technology watch)- PROJECT (project management)- MARKINNOV (marketing of Innovation)Complete 28 Innovation Consultancy Assignments in the following French regions: Rhône-ALpes, Bourgogne, Franch-Comté, AuvergneMake available to private and public organisations promoting innovation, the experience gained in this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GEnetic NEtworks as a tool for anti-CAncer Drug Development' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Although several therapies target cellular pathways, current small molecules drug discovery is based on identification of inhibitors to single proteins, without knowledge of whether they are the most advantageous target. The objective of this proposal is to develop a novel method for drug discovery, combining phenotypic cell based screens with functional genetic networks to determine the molecular mechanisms of numerous small molecule inhibitors. This method will enable identification of numerous distinct inhibitors of a particular pathway, as well as providing their molecular mechanism.Cancer cells harbour gene mutations that make them more reliant on other cellular pathways for survival. Such cellular pathways can be targeted to selectively kill the cancer cells using the concept of synthetic lethality. In this project we want to identify inhibitors of homologous recombination to target cancer using synthetic lethality.To establish a functional genetic network for homologous recombination, we will first identify all recombination proteins using multiple genome-wide RNAi screens. Then the synthetic sick or lethal interaction map between all recombination proteins is determined by co-depletion of these. Such synthetic sick or lethal network will identify numerous putative targets for anti-cancer treatment. Importantly, using this network for chemical-genetic functional interactions will assist in determinating of the molecular mechanisms of inhibitors. Chemical-genetic networks based on synthetic sickness or lethality can potentially change future drug discovery methods as well as providing new mechanistic insights into the field of toxicology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mobile media and entertainment services' (MOMENTS).

assistant: **Innovation**

The project objective is to demonstrate the technical feasibility and business viability of a wireless media highway for the distribution of advanced multimedia products. The project will:contribute significantly to the understanding of users' perception of the value of wireless multimedia servicesidentify how commercial exploitation of the services using third generation systems can be acceleratedcreate new enabling technologies, in particular for the presentation of visual materialassess by qualitative and quantitative means the feasibility and velocity of electronic money transfers during the trialsmake valuable contribution to standardisation.The objectives of the project are reflected in the final project outputs, which are:a comprehensive evaluation of the complete business chain for interactive, wireless multimedia servicesbusiness plans for commercial services for all players in this marketrecommendations for regulatory, legal and commercial practices and structures which will encourage service take up, usage and exploitationcontribution to the standardisation work for the optimisation of multimedia, UMTS and GSM standards for interactive wireless services.The main achievements reached until now are:* the configuration for the Service Platform has been defined, and the HW and the SW for the Basic Service Platform and terminals for 100 end-users have been delivered and installed to each trial network* preparations for the Service Trials, including the setting-up of the operating and supporting organisations, have been completed, and the feedback process has been defined* customer surveys on multimedia services were carried out in each trial country, and the Service Description (Issue 2) document was released based on the results from the surveys* basic and enhanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'NOvel Vegetal-based Extracts Additives for CHEMical-Free FOOD'.

assistant: **Objectives**

The main objective of NOCHEMFOOD is the development of a novel class of food-additives based on a mixtures of substances extracted from vegetal sources. A group of potential assailants to food safety is represented by food additives which are still one of the most misunderstood topic in foods that raises consumer's concern. Food additives play an important role in today's complex food supply. Food controls focuses mainly on chemical additives, which are very often present, even if only in minor, or trace amounts. They are intentionally added to food in order to produce a desired positive effect, although their level has to be maintained within regulated limits. NOCHEMFOOD will develop a new biotechnological strategies aimed at producing foods containing mainly natural ingredients, and from which possibly harmful chemical components have been removed. In particular, it will be investigated the potential use in the sausage industry of natural preserving agents, constituted by a mixture of active molecules extracted from vegetal sources, in substitution of chemical additives. These extracts will be mainly obtained using environmentally friendly extraction processes. The substances will be tested as substitutes for chemical additives such as nitrates and nitrites. These are widely used, with the aim of improving the storage of the product, to better preserve its colour, taste and flavour and finally, to maintain its texture. Before their use, the new products will be tested for their antimutagenicity and antimicrobial capability against undesiderable or pathogenic microorganisms. Evaluation of possible protein damage will be performed. The obtained products will be monitored from a microbiological point of view and biochemical point of view. The products will be analysed du
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Reconstructing the 4D space of intracellular lipid phase separation and lipid droplet biogenesis'.

assistant: **Objectives**

Lipid droplets (LDs) are neutral lipid (NL) storage organelles, central for cellular metabolism. Current models of LD biogenesis postulate that synthesis of NLs in the ER bilayer favors their phase separation, followed by bending of the bilayer and budding of the LD into the cytoplasm, coordinated by a specific, not fully characterized, molecular machinery. Understanding of LD biogenesis through direct observations at molecular resolution is critically lacking. A major obstacle is that conventional electron microscopy techniques, lending the required resolving power, do not preserve the detailed membrane architecture of the ER and the fine structure of the macromolecular machinery driving LD biogenesis.I propose an ambitious cryo-correlative light and electron microscopy (CLEM) study to construct 3D structural models representing the timeline of LD biogenesis in human cells. Using a combination of 4 key proteins tagged with fluorescent markers in cells stimulated towards LD biogenesis, I will stage and image all early events. As nascent LD intermediates are a priori nano-scale structures dispersed within the ER, accurate cryo-CLEM is crucial. I will address this technical challenge with two strategies: cryo-superresolution CLEM and genetically-coded multimeric nanoparticles as markers for cryo-EM. This project harnesses state-of-the-art methods to synergize physical chemistry, structural and cell biology. The high resolution and pristine structural preservation exclusively attainable with in situ cryo-EM will provide first direct observations of early LD assembly, allowing construction of comprehensive 4D models of intracellular lipid phase separation and LD biogenesis.


**Keywords:** Cryo correlative light and electron microscopy, lipid phase separation, lipid droplet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Versatile and environmentally friendly new reaction methodology for synthetic organic chemistry with application to medicinal chemistry'.

assistant: **Objectives**

Enantioselective catalysis is the most important frontier of synthetic organic chemistry and is essential to biomedical research and drug discovery. As nature uses enzymes to catalyze highly stereoselective reactions, it was long assumed that complex struc tures are essential to attain high enantioselectivity. However, it has now been illustrated that small molecule organic catalysts can approach the enantioselectivity and reactivity characteristics of enzymes, omitting the need for toxic organometallic cata lysts or ¿strong¿ Lewis acids. To date, surprisingly few asymmetric organocatalytic transformations have been developed, despite the availability of enantiopure organic chemicals and the accordant academic, industrial, environmental and economic benefits o ver existing methods.The proposed outgoing phase project would further the development of new enantioselective organocatalysis methods, within the pioneering research group of Prof. David MacMillan at Caltech. This research group recently designed a range of highly efficient new organocatalysts and pioneered a variety of catalytic asymmetric transformations of immense practicality and synthetic utility.The return phase would permit the development of a drug discovery project within the laboratories of Astr aZeneca. This work would complement the researcher¿s training and enable integration of the organocatalysis technologies within European industry.The mobility, importance of the research topic and high profile academia-industry collaboration would encourag e co-operation between research disciplines and provide opportunity to widely advertise participation in Marie Curie actions. Overall, the two phases would benefit a motivated European scientist to develop many new skills. Important networks of internation al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Valves for OiL regulaTion with High AccuracY and REliability' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The objectives of the project VOLTAYRE is to design, develop, manufacture, test and qualify an innovative TRL 5 oil valve (OV) able to regulate accurately two oil flows to the gearbox and the engine of the Ultra High Bypass and High Propulsive Efficiency Geared Turbofans and its oil system, and reject the remaining extra flow coming from the oil pump to the tank. This valve will also communicate to the FADEC the delivered flows and allow the FADEC to close the loop via valve’s commands.The VOLTAYRE proposal innovation is based on the innovative low energy limited angle torque motor (LATM) developed and patented by FACT for similar application. This torque motor is able to provide high torque, high displacement, high ageing stability, without dynamic seals to direct drive both a rotary metering direct drive valve (RMDDV) or a rotary split direct drive valve (RSDDV). The RMDDV is coupled with a three-way delta pressure regulator (DPR). This DPR is able to regulate a constant delta pressure between the inlet and the outlet of the RMDDV. This DPR will be able to reject the extra flow provided by the pump to the tank and regulate a constant differential pressure across the RMDDVTwo identical differential pressure flowmeters (DPF) located after the RSDDV, one for the engine line the other for gearbox line, able to provide the requested high accuracy with the necessary reliability in this harsh environment.As part of this response, we have proposed an architecture of equipment possible by combining different bricks TRL3 or 4. These bricks are however a capacity to be organized differently, to provide other architectures for the equipment according to the detailed needs that the topic leader will express through its specification


**Keywords:** Valves, regulation, oil, flow, 4
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'VIRTUAL Real Time Emergency Simulator' (VIRTUALFIRES) under Fifth Framework.

assistant: **Objectives**

A Virtual Reality Real Time Fire Emergency Simulator (VIRTUALFIRES) will be developed. The VIRTUALFIRES system will be a unique system that can be used for assessing the fire safety of tunnels, for training of rescue personnel and for planning rescue scenarios and will be able to replace real fire tests. The end users of this system will be tunnel operators, government organizations concerned about tunnel safety and rescue organizations such as fire brigades. The system can be used for ascertaining the fire safety of existing European tunnels.Objectives: The project has the following objectives:- To offer a cheaper and environmentally friendlier alternative to real Fire tests currently being carried out in tunnels by replacing them with virtual tests;- To develop and implement a virtual fire emergency simulator (VIRTUALFIRES) with complete user interaction;- To contribute to the improvement of the fire safety of tunnels by allowing to perform a large number of inexpensive fire tests for the evaluation of rescue scenarios and for testing fire safety and ventilation systems;- To make VIRTUALFIRES available for use by tunnel operators, designers and government regulatory authorities.Work description: The work in order to achieve the objective namely to develop, test and evaluate the VIRTUALFIRE system is divided into 7 work-packages. The first work-package ensures that the consortium works efficiently and that information is available to all partners. The other work-packages are: Specification of the systems capabilities so that they meet end user needs, selection of developer tools to ensure portability of software. Data pre-processing and ways of optimising the display of very large amounts of data containing the results of 3-D transient combustion (CFD) calculations. CA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Statistical Methods For High Dimensional Diffusions' (STAMFORD) targeting Horizon 2020.

assistant: **Abstract**

In the past twenty years the availability of vast dimensional data, typically referred to as big data, has given rise to exciting challenges in various fields of mathematics and computer sciences. The increasing need for getting a better understanding of such data in internet traffic, biology, genetics, and economics, has lead to a revolution in statistical and machine learning, optimisation and numerical analysis. Due to high dimensionality of modern statistical models, parameter estimation is a difficult task and statisticians typically investigate estimation methods under sparsity constraints. While an abundance of estimation algorithms is now available for high dimensional discrete models, a rigorous mathematical investigation of estimation problems for high dimensional continuous-time processes is completely undeveloped.The aim of STAMFORD is to provide a concise statistical theory for estimation of high dimensional diffusions. Such high dimensional processes naturally appear in modelling particle interactions in physics, neural networks in biology or large portfolios in economics, just to name a few. The methodological part of the project will require development of novel advanced techniques in mathematical statistics and probability theory. In particular, new results will be needed in parametric and non-parametric statistics, and high dimensional probability, that are reaching far beyond the state-of-the-art. Hence, a successful outcome of STAMFORD will not only have a tremendous impact on statistical inference for continuous-time models in natural and applied sciences, but also strongly influence the field of high dimensional statistics and probability.