RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sustainable Jet Fuel from Flexible Waste Biomass' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

FlexJet will build a pre-commercial demonstration plant for the production of advanced aviation biofuel (jet fuel)  from waste vegetable oil and organic solid waste biomass (food waste), successfully demonstrating the SABR-TCR technology (traditional transesterification (TRANS) and Thermo-Catalytic Reforming (TCR) combined with hydrogen separation through pressure swing adsorption (PSA), and hydro deoxygenation (HDO) and hydro cracking/ isomerisation (HC)) to produce a fully equivalent jet fuel (compliant with ASTM D7566 Standards). This project will deliver respective environmental and social sustainability mapping and it will validate a comprehensive exploitation business plan, building on already established end user interest with existing offtake agreements already in place with British Airways. The project plant installed at the source of where the waste arises in BIGA Energie at Hohenstein (Germany) will produce 1,200 ton of jet fuel from 3,482 tonnes of dried organic waste and 1,153 tonnes of waste vegetable oil per year. A subsequent scale-up first commercial plant would be constructed immediately after the project end to produce 25,000 tonnes per year of aviation fuel. The FlexJet project consortium has undoubtedly  bought together the leading researchers, industrial technology providers including airline off takers and renewable energy experts from across Europe, in a combined, committed and dedicated research effort to deliver the overarching ambition. Building and extending from previous framework funding this project is designed to set the benchmark for future sustainable aviation fuel development and growth within Europe and will provide a real example to the rest of the world of how sustainable aviation biofuels can be produced at both large and decentral
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

FLAMIN-GO aims at developing an Organ-on-Chip technology for clinical trials on Rheumatoid Arthritis (RA). In RA, a number of unmet needs still persist particularly related to response/non-response of powerful but expensive drugs. Conventional clinical trials may address part of these challenges, but are time consuming, expensive and ethically ethically doubtful  as part of the patients still fail to achieve disease benefits. Thus, the rheumatology community has a need for an alternative strategy that can deliver innovative trials.FLAMIN-GO develops a personalized next-generation synovia-on-chip, that, by effectively mimicking the complexity of RA joint, will allow performing personalized clinical trials-on-chip. The solution will be based on design and fabrication of a multi-compartment microfluidic platform, for 3D culturing and perfusion of all the disease-relevant joint tissues. It focuses on synovia and synovial fluid, which are the pathogenetic targeted tissues, but including immune system, who sustain the disease, and cartilage and bone which are the end damaged tissues, leading to permanent disability. Starting from individual patient biopsies, this model seeks to replicate RA joints, thus allowing to test and allocate the best on-market drug for that patient in 1-2 months starting form biopsy. When validated, the platform will also be a turning point for i) pharma by enabling screening of new drugs reducing costs, time, and animal testing and for ii) translational research for identification of new biomarkers or therapeutic targets.FLAMIN-GO consortium features a strong, well-balanced composition of hospital, academia and industry partners, who cover with complementary expertise the whole value chain. It gathers experts in the fields of rheumatology, material s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Responsible Open Science in Europe'.

assistant: **Innovation**

Open science (OS) where research planning, processes, data and results are freely available to all stakeholders is the future of science. OS will make science more effective and more responsive to societal needs, and it will enable citizens to participate actively in all aspects of science as citizen scientists. OS does, however also raise new questions about research ethics, integrity and misconduct. We know that research misconduct and questionable research practices occur in our current scientific processes, and it is likely that similar or new forms of misconduct and questionable practices will emerge in OS. It is therefore important to identify and analyse the potential for misconduct in various areas of OS practice and in different scientific disciplines, and to identify and analyse current ethical, social and legal approaches to responding to questionable practices. It is only based on such an analysis that the European science system can effectively ensure that ethics and research integrity (ERI) becomes a structural component of Open Science.   ROSiE will provide this analysis and develop practical tools aimed at ensuring ERI in OS and citizen science (CS). This will be done by a strongly multi-disciplinary project group consisting of world-leading experts and organizations in OS, CS, and ERI. We will: EXPLORE: Provide a systematic inventory of ERI, social, and legal implications and challenges of OS; and of existing technologies and platforms that safeguard responsible OS. ENGAGE:  Conduct consultation and stakeholder engagement aimed at creating and sustaining a community of practice involving all European stakeholders interested in OS and ERI.   GUIDE: Conduct a strategic policy assessment for promoting responsible OS and develop operational guidelines for r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Optimization Algorithms for Split Learning'.

assistant: **Innovation**

With the rapid evolution of Artificial Intelligence, distributed machine learning methods such as Federated Learning (FL) are becoming ubiquitous in present-day technology. In FL, devices train neural network models while data stays local. A central entity then aggregates the model updates into a global model. Split learning (SL) has been recently proposed as a way to enable resource-constrained devices to participate in this learning framework. In a nutshell, SL splits the model into parts, and allows clients (devices) to offload the largest part as a processing task to a computationally powerful helper (edge server, cloud, or other devices). Essentially, SL is a paradigm shift offering a more flexible version of FL that alleviates the load at the devices by better utilizing other available resources in the network. However, this method comes with optimization challenges since networking decisions need to be made in order to orchestrate the SL operations and overcome any communication overhead. Despite the increasing attention towards SL, current algorithms focus on minimizing the training time and improving on energy efficiency, without however bearing any performance guarantees. In order to make SL efficient, OPALS will fill this crucial gap by providing algorithms with provable guarantees. In particular, OPALS focuses on 3 main research axes. First, it studies the well-established problem of minimizing the training time, in search of the first algorithm with guarantees. Second, it seeks ways of leveraging SL to reduce the carbon footprint of distributed learning. Third, it investigates how SL could be employed in a decentralized setting in view of the increasing importance of swarm intelligence. OPALS will employ mathematical modelling and cutting-edge optimization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mycolic Acid Cyclopropane Synthase Enzymes as New Biocatalysts for Green Cyclopropanation Reactions' in the context of a Horizon Europe call.

assistant: **Objectives**

Cyclopropane rings are a key structural motif that may be found in a wide range of natural products, chemicals, fragrances and pharmaceuticals. Current methods for the manufacturing of cyclopropane-containing molecules show significant limitations in terms of safety, environmental impact and green metrics. Only a few biocatalytic methodologies for the asymmetric synthesis of cyclopropanes have been developed so far, and they rely on repurposed or artificial heme enzymes (P450, myoglobin). However, these approaches suffer from significant limitations in terms of ""green chemistry"" and industrial application since they require stoichiometric amounts of hazardous diazo-compound reagents as co-substrates. Overcoming these limitations is a critical challenge that underscores the need for further research and development in 'green chemistry' and industrial application of biocatalysis. Mycolic Acid Cyclopropane Synthases (MACSs) are pivotal cyclopropane synthase enzymes found in mycobacteria, such as M. tuberculosis. They are a group of homologous enzymes in the mycolic acid biosynthesis pathway, and they are crucial in catalysing the cyclopropanation of double bonds. Since MACSs use S-adenosyl-L-methionine (SAM) as a methylene donor rather than diazo-carbene co-substrates, they present a viable option for creating mild and sustainable cyclopropanation biocatalysts. Furthermore, with their ability to catalytic cyclopropanate short- to long-chain unsaturated fatty acids and their ease of bioengineering, these enzymes present a novel and exciting opportunity for future biocatalyst development. This project focuses on the characterization and development of MACSs as cyclopropanating biocatalysts through enzyme engineering approaches.""


**Keywords:** Biocatalysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integration of living cells with organic transistors for the rapid detection of toxins and enteric pathogens'.

assistant: **Objectives**

The epithelium plays a significant role in resistance to infection in mammals, and is made up of a single layer of elongated, column-shaped cells that line the stomach and colon. This single layer of epithelial cells restricts the entry of toxins and pathogens, while selectively absorbing nutrients that sustain the body. Pathogens have devised multiple mechanisms to destroy the integrity of the intestinal epithelial barrier, compromising the normal absorption of water in the intestine and thereby causing diarrheal disease. The World Health Organization estimates that in 2005 alone 1.8 million people died from diarrheal diseases. CELLTOX is a novel type of biosensor for the detection of enteric pathogens and toxins, based on the principle of using live epithelial cells grown on an organic electrochemical transistor (OECT), which provides a very sensitive and convenient means of measuring ionic transport. When the epithelial cells form a monolayer, the integrity of the cell monolayer prohibits ion transport keeping the transistor in the ON state. Assault of the cells by an enteric pathogen or toxin will lead to a disruption of the cell monolayer and enable ion migration into the polymer, switching the transistor OFF. This novel “canary in a coal mine” platform will constitute a broad first-line diagnostic for gastrointestinal disease, with applications for food and water safety. It will lead to sensors that are fast, portable, inexpensive and label-free. Future use of different cell lines (eg. bronchial, dermal, etc.) with this platform will lead to a host of sensors for applications in medical diagnostics, agriculture, and environmental protection. This multidisciplinary project encompasses the disciplines of organic electronics, cell biology and microbiology, and will c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identifying pathways of cellular nanoparticle uptake and early processing for novel nanomedicine applications' (NanoPaths) under Horizon 2020.

assistant: **Objectives**

Nanotechnology applied to medicine has opened tremendous opportunities for the design of devices capable of targeting cancer and other diseases, and to deliver therapies selectively to locations where drugs currently can scarcely arrive. Translation of nanomedicines to the clinic however still remains challenging and the mechanistic details of the pathways used by cells to internalize and process man-made nanoparticles are still poorly understood.NanoPaths aims to understand how nanoparticles are processed by cells and in particular (1) to disentangle the mechanisms they use to enter cells, and (2) discover whether highly curved nanosized objects can assist cell membrane curvature, thus play an active role in their internalization; (3) to isolate the structures in which nanoparticles are internalized, in order to understand early sorting by cells, and further characterise the machinery for internalization; and finally (4) to define heterogeneity in cell response to nanoparticles in all of these aspects due to population context (i.e. cell cycle, local cell density) and identify eventual rare-cell behaviours. Several methods to ensure quantitative nanoparticle-cell interaction studies and discriminate cell subpopulations have already been developed in my previous work and now allow me to ask these questions. These methods will be combined with novel approaches applied for the first time in this arena, such as the use of full genome screens to study uptake; single molecule fluorescence methods to understand the role of nanoparticle curvature; novel cell fractionation methods coupled to quantitative proteomics to identify key proteins involved in uptake and early sorting; individual cell analysis to address heterogeneity in cell response to nanoparticles and study rare cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Shift2SDV - a common Software development framework and hardware independent microservice-oriented middleware architecture for the stepwise migration to the Software Defined Vehicle of the Future' to be submitted under Horizon Europe.

assistant: **Abstract**

The Shift2SDV project aims to revolutionize the European automotive domain by creation of an SDV ecosystem around middleware & API framework enabling collaboration across the automotive value chain. This ambitious endeavour envisions a comprehensive shift towards a modular framework that transcends the limitations of current monolithic systems, fostering agility and innovation through the development of complementary middleware services and software development solutions.Central to Shift2SDV is the development of a cutting-edge middleware framework that provides micro-services to build automotive applications upon, abstracting from underlying hardware components – supporting stepwise migration, open source and proprietary components, in-vehicle safety critical and off-vehicle cloud functionality. It is specifically designed to streamline software development and integration while ensuring compatibility and flexibility with existing and emerging technologies. Key technical objectives include the development of a modern, flexible micro-services-based architecture, middleware framework that simplifies the brand-specific application development, and establishment of a safe and secure system architecture compliant with functional safety standards. Additionally, the project aims to develop an orchestration for efficient resource management, integrate edge and cloud computing, and demonstrate the practical viability of the developed middleware through concrete use cases. To maximize impact, Shift2SDV prioritizes active communication, dissemination, and exploitation of project outcomes, fostering collaboration among stakeholders and existing projects and initiatives aligning technological advancements with market demands. Through these concerted efforts, Shift2SDV seeks to prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Self-assembly with carbon nanotubes: towards devices for information processing' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Carbon nano-tubes, due to their unique electrical and mechanical properties have aroused a great interest as one of the best candidates for Molecular Electronics. The project will study the growth, nano-manipulation as well as the electronic properties of single wall carbon nano-tubes (SWCNT) with a particular emphasis on junctions. The work will be focused on the study of nano-manipulation techniques based on self-assembly and chemistry modifications. The material will be obtained by laser ablation technique. As a powerful alternative, in-situ growth of CNT will be addressed using CVD. Using these techniques, various types of junctions will be fabricated and their transport properties will be studied. Optimisation of the processes will be performed using diverse characterisations techniques associated with modelling. The final objective is to demonstrate the applicability of CNT for the fabrication of electronic devices.Carbon nano-tubes, due to their unique electrical and mechanical properties have aroused a great interest as one of the best candidates for Molecular Electronics. The project will study the growth, nano-manipulation as well as the electronic properties of single wall carbon nano-tubes (SWCNT) with a particular emphasis on junctions. The work will be focused on the study of nano-manipulation techniques based on self-assembly and chemistry modifications. The material will be obtained by laser ablation technique. As a powerful alternative, in-site growth of CNT will be addressed using CVD. Using these techniques, various types of junctions will be fabricated and their transport properties will be studied. Optimisation of the processes will be performed using diverse characterisations techniques associated with modelling. The final objective is to demonstra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Towards the establishment of a European e-health research area' in the context of a Sixth Framework call.

assistant: **Objectives**

The goal of the proposed CA is to coordinate planning of national innovation-oriented e-health RTD as the basis for a common road-map and joint RTD activities, thereby establishing an effective ERA in this key IST field and important European market. Reducing the serious fragmentation of current planning can be expected to have a strategic impact on regional, national and trans-European e-health infrastructures, improve the quality of medical outcomes and hence the quality of life of citizens in Europe.The CA emerged from an initiative involving 20+ Member States Health Ministries to improve RTD coordination and exploit the potential for European synergy. They wish to avoid barriers to patient and professional mobility in the Union threatening from uncoordinated IST uptake and ensure progress in line with the Commission's e-Health Action Plan. The consortium of 5 research management bodies - coordinated by empirica at the request of the German Ministry - will research and structure European e-health RTD, build a suitable e-health ERA portal, identify priority topic clusters, locate cooperation opportunities, identify best practice, set consensual benchmarks, propose priorities for action and draw up a coherent Europe-wide road-map and action plan, finally proposing sustainable long-term mechanisms for European coordination.A Steering Committee, to which over 25 Ministries have already committed, will oversee and direct work, adopt priorities and road-map, initiate engagement in joint RTD activities and adopt sustainable mechanisms. The project will thus achieve greater transparency across Member States, effectively address the fragmentation of the current European e-health research landscape, counter the poor uptake record of e-Health RTD to date by being consistently i