RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ComputationaL dEsign optimization for unpolluted wAteR' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The increased use of pharmaceutical drugs and agriculture chemicals in the last five decades now results in a global contamination of the water cycle. Antibiotics, endocrine disruptors, pesticides are among the most alarming compounds found in wastewaters and even in treated waters. Currently, wastewater treatment plants are the most significant barriers to water contamination, but are known to fail in decreasing micropollutants concentrations to reasonable levels. Consequently, there is an urgent need to implement technologies for removal of micropollutants from wastewaters before they reach rivers, groundwater and marine waters.EDEN MICROFLUIDICS offers a compact, easy-to-deploy, cost-effective technology for micropollutant removal, thus giving access to quality water to the EU and beyond. The system uses microfluidics for treatment of high volume of effluent at low pressures, decreasing significantly energy consumption compared to current techniques. But the fluidic design, while efficient, fails to adapt for the wide range of pollutants and their properties. The fluidic architecture should be dependent on pollutant types, sizes, concentration, ... Designing with such a large array of parameters requires expertise in a specific computational method:  Computational Design Optimisation. The objective of the research proposed here is to optimize the design of the devices developed by EDEN by means of computational methods. We will build the necessary physics-based or data-driven models to enable the use of numerical optimization algorithms to determine optimal design solutions for a variety of conditions and requirements. We will employ multidiscisplinary design optimization techniques to account for the interaction of different disciplines entailed in the treatment pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Joint Volumetric Reconstruction and Automated Analysis of the Fetal Heart from Cardiovascular Magnetic Resonance Images' (JUNO), addressing dissemination and exploitation.

assistant: **Impact**

Recent advancements in cardiovascular magnetic resonance (CMR) have finally made possible static and dynamic in-vivo imaging of the fetal heart. This new capability has the potential to provide a fundamental new tool for structural and functional assessment of the fetal cardiovascular system, with groundbreaking clinical consequences. In fact, congenital heart diseases (CHDs) and intrauterine growth restriction (IUGR, which induces cardiovascular remodeling) are among the leading causes of infant mortality worldwide. Fetal CMR imaging may potentially allow more accurate diagnosis of these conditions, and thus improve postnatal outcomes thanks to better in-utero therapy administration, delivery and perinatal intervention planning. Unfortunately, fetal CMR is currently limited to the acquisition of a single slice in time, allowing only qualitative and operator-dependent evaluation of the fetal heart. The JUNO project aims at improving the present capabilities of fetal CMR by tackling its limitations with an image processing approach. The specific goals are (1) development of a method for super resolution volumetric reconstruction of the fetal heart, using image registration techniques applied to a set of single-slice acquisitions; (2) development of automated segmentation methods, based on deformable models and atlases, for the identification of structures such as ventricular contours and main vessels’ boundaries; (3) extraction of quantitative functional parameters (e.g. stroke volume and ejection fraction) from datasets acquired from healthy, CHDs- and IUGR-affected fetuses, to test the feasibility of objective detection of these conditions. By achieving these goals, JUNO will provide an innovative set of methods allowing for the first time quantitative, noninvasive, fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The effects of lineage differentiation into pancreatic beta-cells on the immunogenicity of amniotic fluid stem cells' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The use of stem cells for curing disease and ending disabilities may change the medical treatment in this century. However, there are some major roadblocks that need to be resolved before these cells are implemented in ordinary medical care. There are serious ethical issues regarding the use of embryonic stem cells, reliable methods for isolation and expansion of stem cells need to be established, stem cell plasticity raises the issue of tumorigenicity, the use of stem cell transplantation might encounter with rejection and more information is needed on stem cell immunogenicity. This proposal aims to address some of these roadblocks. Replacement of β-cells by transplantation of pancreatic islets has become a viable option for the treatment of certain patients with unstable Type 1 diabetes mellitus. However, the current supply of islets from pancreata of organ donors is very limited. Stem cells may serve as a new source of β-cells. Although promising results have been reported in the production of β-like cells from human embryonic stem cells, the process appears relatively inefficient. We have described the isolation of a novel class of human amniotic fluid stem (AFS) cells and showed that they are capable of extensive clonal expansion and can give rise to differentiated cell types derived from all three embryonic germ layers, but do not form teratoma tumors. Experiments with mouse AFS cells show that, when we forced the expression of the pancreatic transcription factor PDX-1, the cells can be induced to form islet-like clusters containing a high proportion of cells that synthesize proinsulin and display glucose-stimulated insulin secretion. Studies with human AFS (hAFS) cells have confirmed that they can express mRNA for critical beta-cell lineage functions. However, in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ERA TALENTS FOR BOOSTING AND BALANCING BRAIN CIRCULATION' (TBrainBoost), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective of the TBrainBoost is to boost international and intersectoral mobility and improve links between academia, business and society in the field of healthy aging.  TBrainBoost will achieve this through a series of secondments between academic institutions and businesses working in the field of healthy aging, and a number of educational activities. Based on our methodology, researchers from this multidisciplinary field will enhance their entrepreneurial skills and competences while bringing their valuable research expertise to the industry, while R&I talents will gain new insights and skills to create structural changes that are required to set strong foundations for academy-business collaboration for the future. All intersectoral secondments will also put emphasis on benefiting institutions from widening countries, namely empowering talents from Slovenia and Malta with opportunities to learn from colleagues in Germany, the Netherlands and Belgium. Ultimately, the TBrainBoost project will create a reality where scientists and R&I talents from all parts of the spectrum intuitively share knowledge, experience and skills to boost their personal profiles, work for the benefit of the aging society, and drive our economies.


**Keywords:** academia-industry collaboration, reversed brain drain, aging, ageing, lifelong learning, entrepreneurship, seconded experts, movement science, skills, competences, improved public health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dissecting mGlu5 receptor internalization pathways using genetic and pharmacological tools'.

assistant: **Concept**

The metabotropic glutamate receptor 5 (mGlu5) is part of the large family of G protein-coupled receptors (GPCRs) that are the target of 30-40% of marketed drugs. mGlu5 is a key regulator of synaptic plasticity in the brain and a major drug target for a wide range of diseases, such as Fragile X syndrome. Agonist-induced internalization is a major regulatory mechanism for GPCR signalling. Interestingly, mGlu5 internalizes via a mechanism that is distinct from the canonical beta-arrestin mediated pathway. However, the details of this alternative mechanism are largely unknown for mGlu5 and poorly understood for GPCRs in general. The present project has the dual aim (1) to dissect the intracellular pathways leading to mGlu5 receptor internalization and its functional implications and (2) to develop a genetic and pharmacological toolbox to study beta-arrestin independent internalization.I will generate a series of HEK293 cells where key proteins involved in a range of GPCR internalization pathways have been systematically removed by CRISPR/Cas9 genome editing. These cell lines will complement the already existing G protein alpha subunit and beta-arrestin knockout HEK293 cell lines to generate a highly efficient toolbox to study pathways and mechanisms involved in GPCR signalling, internalization and regulation. In the present project, I will employ theses cell lines to dissect pathways leading to mGlu5 internalization. To enable future studies in cells with native mGlu5 receptor expression, pharmacological tool compounds/peptides targeting key proteins identified will be developed using the genome edited HEK293 cells. This will provide essential information about the regulation of this important drug target and beta-arrestin independent internalization.Importantly, we will ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Towards local circular economy: biomass-based pyrogasification process for the production of green hydrogen', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Hydrogen is meant to be one of the most important renewable energy sources of the future since it is a flexible energy carrier that will facilitate significant reductions in energy-related CO2 emissions, what would favour to meet requirements of EU energy policies and fight against climate change. However, it is necessary to overcome infrastructure challenges and high productive cost to achieve a competitive alternative to other renewable energies. T’AIR ENERGIES is a French SME which aims at bringing to market an innovative energetic model where the local biomass and waste are valorised to produce and distribute green hydrogen for mobility (fuel cell electric cars), energy (electricity/gas) and industrial applications. Our innovative solution, called Hydrogreen, is a pyrogasification-based process where biomass (wood, wood waste, straw) is converted, with optimum efficiency, into energetic hydrogen and decarbonated CO2. Our methodology proposes an integral process based on the valorisation of locally available material and agricultural surpluses through a decentralized process that guarantees huge savings in terms of logistical costs (-66%) for the system's inputs. In addition, thanks to the optimization of the resources used and the introduction of waste/products at the end of their life in the productive cycle, it is fully aligned with the principles of the circular economy. Finally, the distribution of H2, in which the traditional service stations are complemented with a personalized system where our logistics partners directly transport the fuel to the end users, solves a key mobility bottleneck, further boosting the growth of the number of vehicles based on clean hydrogen energy. As Hydrogreen will enable us to offer green hydrogen to local actors at a competitive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Translational reserach in paediatric rheumatology'.

assistant: **Innovation**

Paediatric rheumatic diseases are a group of chronic disorders characterized by high morbidity that collectively represent one of the leading causes of acquired disability in childhood. They include juvenile idiopathic arthritis, juvenile systemic lupus erythematosus, juvenile dermatomyositis, juvenile scleroderma and systemic vasculitides. Translational Research in Paediatrics (TRiPR) is a coherent series of events which will aim to acquaint younger generations of European researchers and clinicians with the key issues underlying the development of new therapeutic strategies for paediatric rheumatic diseases, seeking above all to enhance their translational research skills in the field.Running parallel to this overriding aim will be TRiPR's intent to enhance the European contribution to:a) the understanding of pathogenic mechanisms in rheumatic disorders;b) the discovery of new therapeutic approaches;c) the definition of the best models, for rare conditions such as childhood rheumatic diseases, to test new potential effective drugs/agents.Lastly, clinicians and researchers dealing with adult rheumatic diseases will be able to benefit from these conferences, thus fostering relations in Europe between paediatric and adult rheumatologists and thereby leading to the creation of an even more extensive network among European researchers interested in chronic inflammation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Middle Infrared Broadly Tunable Compact Cavity-Less Source based on Parametric Conversion'.

assistant: **Concept**

The middle-infrared (Mid-IR) is a core band for molecular detection and identification as nearly every molecule strongly absorbs in this wavelength range. Hence, it hosts critical applications ranging from spectroscopy, health monitoring, sensing as well as free space communication. Unfortunately, the advantages of this wavelength range have not been fully exploited due to the lack of Mid-IR sources that can simultaneously satisfy stringent requirements these diverse applications impose. To this end, MATISSE seeks to transfigure light generation in the Mid-IR spectral band by designing new classes of nonlinear frequency mixers. We aim at overturning the limitations of conventional resonant (cavity) processes by simultaneously enabling mode-hop free tuning, narrow linewidth and wide tunable range operation. In addition, we also plan in developing the first modulation-capable source across a wide range of Mid-IR frequencies. To overcome these challenges, MATISSE will leverage the cavity-less nature and parametric origin of the proposed source. The project will cascade two distinct  compact nonlinear platforms to enable the efficient wavelength conversion from NIR to Mid-IR. This two-step approach takes advantage of attributes each distinct platform has to offer by 1) utilizing the advanced technology available at the NIR wavelengths and 2) exploiting the Mid-IR capabilities of non-silica platforms.  We believe only an approach such as ours can provide a compact, freely tunable Mid-IR source without resorting to conventional cavity (resonant) physics. The MATISSE project therefore promises substantial impact in spectroscopy, sensing and free space communication by providing presently non-existing tools that will not only improve the sensitivity of absolute and relative spe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rituximab in patients with acute myocardial infarction: a phase 2 placebo-controlled randomised clinical trial' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

RITA-MI 2 will assess the impact of a novel therapeutic strategy targeting patients’ immune response on the recovery of heart function after myocardial infarction (MI) in a phase 2 clinical trial.Cardiovascular diseases (CVD) represent a major cause of morbidity and mortality worldwide. Despite important advances in the treatment of acute MI, the occurrence of MI still results in left ventricular dysfunction in up to 50% of patients, which leads to the development of heart failure. Left ventricular dysfunction is the strongest predictor of adverse outcome after acute MI, and is associated with a 3 to 4-fold increase in mortality risk. In Westernised countries, heart failure is responsible for 1-2% of all health expenditure, which is mostly driven by repeated hospital admissions. Therefore, there is a considerable need for new therapies to limit the burden of CVD.This application builds on a ground-breaking discovery by a unique team of clinicians and scientists who provided extensive validation for their findings through a series of basic, pre-clinical and translational research. Our goal is to translate this discovery into benefit for patients. The new therapy is based on selective targeting of a specific immune cell subset, mature B lymphocytes, with the aim to limit deleterious cardiac remodelling and improve heart function recovery post-MI. Of note, the drug that targets this pathway, i.e., CD20 monoclonal antibody (mAb) rituximab, is available for testing in a re-purposing scheme, allowing for rapid initiation of proof-of-concept clinical trials. The PIs of the present proposal have successfully completed a phase 1/2a clinical trial (RITA-MI, NCT03072199), which established the safety of rituximab treatment at the acute phase of MI.RITA-MI 2 will conduct a phase 2b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advancing the theory of quantum phase transitions in the era of quantum computing' (TRANGINEER).

assistant: **Innovation**

Understanding quantum phase transitions is one of the biggest challenges in modern physics,  stimulating numerous exciting developments in theoretical, experimental, and numerical physics. Perhaps, the most remarkable, was the invention of conformal field theory, responsible for many exact predictions. This paved the way for numerical and experimental observations of many of these transitions forming, however, a misleading impression that almost all quantum transitions in nature are conformal. But is this imbalance real, or are many exciting non-conformal transitions currently overlooked due to the limitations of our theoretical toolbox?In this proposal, I aim to develop a methodology for the unbiased construction of quantum phase transitions. Recent years have been marked by tremendous progress in non-perturbative computational methods. The invention of constrained tensor networks fully profiting from Rydberg blockade for the first time provides sufficient accuracy to predict novel types of quantum phase transitions. With such a powerful tool at hand, I aim to develop a numerical approach to engineer novel quantum criticalities in experimentally realizable models of Rydberg atoms. Implemented directly on a lattice, my method will not rely on the available field-theoretic description of the transitions and, by construction, will have no bias towards conformal ones, opening a way for systematic study of non-conformal transitions and breaking a new ground in fundamental physics. By focusing directly on the effective models of Rydberg atoms I open a path for immediate experimental validation of my future predictions. This proposal benefits from the latest technological advances and will provide a timely theory guidance for future experiments. My study will be an important