RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pan-European Response to the ImpactS of COVID-19  and future Pandemics and Epidemics' (PERISCOPE) under Horizon 2020.

assistant: **Objectives**

The impact of the COVID-19 pandemic has been deep and wide. In spite of unprecedented efforts to understand the COVID-19 disease and its causative virus SARS-CoV-2, months after the emergence of the first local case in Europe (San Matteo hospital, Pavia, 21st February 2020) significant knowledge gaps persist. While social and natural scientists managed to develop new research and shed light on the dynamics of the outbreak and the most effective possible containment measures, governments have been increasingly faced with the need to adopt urgent decisions. Against this background, PERISCOPE plans to contribute to a dramatically deeper understanding of the dynamics of the outbreak, by means of an intense multi-disciplinary research, both theoretical and experimental, and the consideration of different viewpoints: clinic and epidemiologic; humanistic and psychologic; socio-economic and political; statistical and technological. The overarching objectives of PERISCOPE are to map and analyse the unintended impacts of the COVID-19 outbreak; develop solutions and guidance for policymakers and health authorities on how to mitigate the impact of the outbreak; enhance Europe’s preparedness for future similar events; and reflect on the future multi-level governance in the health as well as other domains affected by the outbreak. In pursuing this objective, PERISCOPE sheds new light on the unintended and indirect consequences of the outbreak and the related government responses, with the intention to preserve evidence-based policymaking by collecting an unprecedented amount of data and information on the social, economic and behavioural consequences of the current pandemic. At the same time, PERISCOPE will produce new information on the conditions that led to the impact of the pande
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'ReVINK'.

assistant: **Objectives**

Verification is an important technique to ensure quality of a system and detect scenarios in which requirements can be violated. For complex systems with multiple interacting components, one of the crucial requirements is a component's ability to achieve a given goal. However, verification of strategic abilities is computationally hard, and the existing model checking algorithms cope with it only partially. This applies especially to systems where components have limited knowledge of the global state of the world.In this project, we propose to advance verification of strategic interaction by focusing more on models, and less on algorithms. Our research hypothesis is that model checking algorithms are approaching the limits of their potential when applied to arbitrary abstract models. On the other hand, certain representations can be more succinct or provide better structural properties. For instance, Reaction Systems encourage the modeler to abstract away from features of individual components. Likewise, Modular Interpreted Systems support additional structural information about separation of interacting components.In order to systematically explore different representations, we identify 3 basic modeling levels for interaction and knowledge. The Agent Level focuses on actions, mental states, and social features of components. The Effectivity Level provides a uniform mathematical representation in terms of abstract effectivity. The population level focuses on interaction between large groups of similar components, and abstracts away from sporadic behaviors. We will begin by establishing mappings between models (and classes of models) from different levels. Based on these mappings, we will identify suitable model equivalences and abstractions that produce more succinct an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Automating the assembly of footwear with bottom stitching techniques' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

During Step One the necessary preparations for a Step Two Proposal are planned. The Exploratory Phase will comprise a detailed literature study, including the study of available patents. This goes together with a detailed market analysis. A search for applicable systems already existing will be included, too. A feasibility study is to be carried out. During the time of the Exploratory Award the SME proposes will have to look for further partners. The Step Two proposal aims at the development of sewing automate able to stitch the soles of shoes to the upper parts. Up to now no such machinery system is known. So the work that must be carried out in order to sew soles of shoes to the upper parts is to be done by hand". The work is tedious and also dangerous for the worker to do. The development of this machinery system which application is not limited to the use in shoe manufacturing will be carried out by at least one machine manufacturer in close co-operation with shoe manufacturers."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Glial cell line-derived neurotrophic factor and the c-ret receptor tyrosine kinase in normal development and neurological diseases'.

assistant: **Concept**

To study mechanisms of GDNF signal transduction, and the ligand-receptor interactions of normal Ret, different RET isoforms and mutants found in Hirschsprung's disease and MEN2 patients. To investigate biological roles of GDNF and other family members and their receptors in the development and maintenance of major areas and pathways of the peripheral and central nervous systems, including those affected in human neurological disorders. To screen for mutations in the GDNF gene in pediatric developmental disorders, such as Hirschsprung's disease and neurointestinal dysplasias, and in Parkinson's disease.To identify and characterize novel receptors for GDNF and other family members. Glial cell line-derived neurotrophic factor (GDNF) maintains central dopaminergic, noradrenergic and motorneurons, as well as various populations of peripheral neurons. GDNF is therefore a most promising candidate for therapeutics of acute nerve injury and chronic neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral sclerosis. A recent collaborative effort from the partner laboratories has established that c-RET, an orphan receptor tyrosine kinase that plays important roles in mammalian development and human disease, is a functional receptor for GDNF. Germ-line mutations of c-ret contribute to developmental abnormalities of the intestinal innervation in a fraction of cases of Hirschsprung's disease or congenital intestinal aganglionosis, and they have also been found in patients with multiple endocrine neoplasia (MEN) type 2 and medullary thyroid carcinoma. The general objective of this proposal is to create a collaborative network among several leading European groups in these research areas in order to accelerate the discovery process at a very expansive moment in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ecodesign methodology for recyclable textile coverings used in theEuropean construction and transport industry' (ECOMETEX).

assistant: **Concept**

The overall aim of EcoMeTex is to develop a tailored Ecodesign methodology for optimising the design of textile coverings with regard to eco-efficiency and cost-effectiveness. This comprises an analysis of the entire life cycle identify significant environmental and economic impacts and hence potential for improvement guaranteeing high product quality, as well as high product safety. Life Cycle Assessment (LCA) allows to identify the crucial weak points in the life cycle and to assess improvement strategies to achieve an environmentally sensitive product design. LCA informs designers and developers concerning the implications of their choices on the environmental impacts and is therefore a decision-making tool. The innovative methodology faces the challenge to solve the paradox of textiles coverings: on the one hand the bonding of the multi layers has to be solid; on the other hand the multi layers have to be easy to dismantle for recycling. Applying this methodology a closed loop system of resources is realised, enabling material recycling. Re-design comprises not only optimisation of currently used material sets or manufacturing and distribution processes but also product and process innovations: It covers the development of innovative material adaptations as well as new approaches within the manufacturing process, recovery and reuse stage itself. The feasibility of the re-design concepts will be proven by producing prototypes of eco-designed textile floor coverings from the construction sector. The work will be completed by describing the methodology in a Code of Pratice which will be implemented in a customised, practical and intuitive software tool. The Ecodesign methodology will provide additionally a communication scheme for external communication based upon LCA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Re-wiring of photosystem II enzymes to metal-oxide electrodes in artificial photosynthetic devices for enhanced photocatalytic water splitting performance' under Seventh Framework.

assistant: **Concept**

Photocatalytic water splitting is an attractive means of efficiently converting solar energy into a storable hydrogen fuel, offering a clean and renewable source of energy that can replace fossil fuel. In this study, the Photosystem II (PSII) enzyme is employed as a biological catalyst in important proof-of-principle studies to establish the basic principles behind emerging artificial photosynthetic devices for efficient light-driven water splitting. Currently, the maximal output of PSII-based photocatalytic water splitting systems is capped by a number of factors, most significantly the non-ideal ‘wiring’ of the enzymes to the electrode giving rise to inefficient electron transfer. The present Marie Curie International Incoming Fellowship (IIF) project proposes to enhance the performance of benchmark PSII-based photocatalytic systems by ‘rewiring’ the electron transfer from the bio-catalyst to the anode to eliminate inefficient steps, and hence establish new maximal outputs achievable by such systems. This will be achieved by directed immobilisation of the PSII to the anode, followed by the inhibition of redox events in the electron flow pathway to bypass the rate-limiting step. Moreover, current photocatatlyic water splitting systems rely on expensive rare-earth components which are ultimately non-sustainable and uneconomical for use in future photocatalytic devices. In this study, newly accessible nano-structured earth-abundant substrates will be investigated as electrode material to ultimately encourage the development of more sustainable systems for photocatalytic water splitting.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimise and predict antidepressant efficacy for patient with major depressive disorders using multi-omics analysis and AI-predictive tool' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

280M of people worldwide suffers from major depressive disorders (MDD). Although a well-populated therapeutic landscape of anti-depre280M of people worldwide suffers from major depressive disorders (MDD). Although a well-populated therapeutic landscape of anti-depressants, the number of patients in remission is particularly low with not more than 6% of the patients who benefit from the current therapeutic journey. OPADE objective is to identify key biomarkers that support the decision-making process of the healthcare providers.The project focuses on the microbiota – brain -axis which plays a major role in mental health and in particular MDD. Through clinical investigations, the consortium partners will study the combination between genetics, epigenetics, microbiome and inflammatory networks to: -Establish patient profiles to predict and optimise the efficacy of the antidepressants prescribed with an increase in the remission rate and reduction of impairment of real-life functioning, -Establish the possible correlation between neuroinflammatory indices, target indicators of the microbiome, metabolomics, immune-profile linked, epigenomic, enzymatic algorithms,-Evaluate molecular and non-molecular biomarkers that may represent predictive indices of recurrence-Discover new molecular targets for a personalised approach,-Improve the diagnostic accuracy for primary prevention,-Evaluate retrospectively, using accurate anamnesis, the onset of depressive symptoms in adolescence.-Establish how much and to what extent do blood biomarkers correlate with other specific biomarkers350 patients between 14 and 50 years will be recruited in 6 EU and international countries for 24 months. Real-time EEG and patient cognitive assessment will be collected with blood, stool and saliva samples.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Excellent phase-change data storage materials' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Today, 4.7 GB DVD discs in use are made of phase-change chalcogenides. In five years, the 1000 GB MODS discs based on the same materials are expected to be commercialized and non-volatile phase-change memories may revolutionize the next generation of laptops and digital cameras.However, as written in Nature last year: A paradoxical situation exists when a device such as an optical disc is functional and commercially available but the structural changes behind the utilized transition are unknown. There is a big European effort in the field of phase-change optical memory, with the main competition being in Japan.Finding out the mechanisms involved should greatly help in increasing European competitiveness in this; for a future technology, which is electrical RAM also using phase-change chalcogenides (USA competitors), the same applies.The aim of the proposed research is to reveal the atomic-scale mechanisms underlying optically and electrically driven phase transformations by using molecular-dynamics computer simulation that will make it possible to monitor atomic motions induced by light or electrical current in phase-change chalcogenides. This knowledge can then be used to develop faster, more stable, and higher capacity phase-change data storage materials.The guarantee for the success of the project is the expertise of the fellow and the host (Prof. S.R. Elliotts group in Cambridge) in the proposed field due to their previous extensive molecular dynamics simulation studies of photo-induced phenomena in chalcogenide glasses.During the fellowship in Cambridge, the fellow will obtain the best possible advanced-research-training in the proposed multidisciplinary area, which is perfectly suited to his individual needs and will guarantee reaching professional maturity as an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fuse smFRET and modeling to a new structural biology method and solve the functional ESCRT assembly structure' to be submitted under Horizon 2020.

assistant: **Abstract**

We seek to develop a new structural biology method that is able to overcome barriers to solving very complex functional protein assemblies that are variable enough in their composition and conformation to defeat current methodologies. I intend to combine high-throughput single molecule FRET (smFRET) experiments with computational modeling to achieve this goal. SmFRET will be used to derive individual building block structures as well as distances between these blocks on a molecule-to-molecule level. Computational modeling is used to fuse this information into a full atomistic model of the protein assembly.The yeast ESCRT machinery is proposed as a model system to develop the new methodology. The ESCRT machinery is particularly important because of its role in HIV infections: HIV seizes control of the cell’s ESCRTs to get released from infected cells. The ESCRT assemblies’ size and flexibility lead to the fact that their assembled structure on membranes is largely unknown. Individual ESCRT proteins will be labeled by Cy3/Cy5. The ESCRT assembly will then be reconstructed on invaginated supported lipid bilayers and imaged via TIRF microscopy. FRET efficiencies will be recorded and the label-label distance determined. High-throughput biochemistry and labeling technology will allow us to generate > 100 distinct labeling sites, resulting in overdetermined structures. Stepwise photobleaching will reveal the stoichiometry within full assemblies. Alterations in FRET efficiency due to local contact formations within the assembly will reveal these local contacts. Based on the experimental data of the individual complexes, their copy number in the assembly and their local contacts, the full assembly will be determined computationally, based on replica exchange Monte Carlo simulati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum GRavity seArches with Neutrino Telescopes' (QGRANT).

assistant: **Concept**

The Standard Model of particle physics and General Relativity are expected to merge into a new theory of Quantum Gravity (QG) at energies approaching the Planck scale. However, none of the proposed QG approaches has been validated to date. In this context, several signatures of QG effects in accessible energy regimes, known as Windows on Quantum Gravity, have been postulated. In particular, quantum decoherence (QD) or QG-induced violation of Lorentz invariance (LIV), could cause modifications in neutrino oscillation patterns accessible to observation with neutrino telescopes.  With QGRANT, I propose a global and novel search for QG effects with the IceCube, ANTARES and KM3NeT neutrino telescopes. The expected results will allow to probe QD and LIV parameters regions not accessible to date. Moreover, the phenomenon of QD will provide new possibilities to investigate the neutrino nature as a Dirac or Majorana particle as well as to trace possible violations of CPT symmetry in neutrino oscillations. Such a phenomenon represents a totally new scenario where to test the real nature of neutrinos.  Within QGRANT, I will analyse the huge amount of data collected by IceCube, ANTARES and KM3NeT, Europe's most ambitious project of a high energy neutrino telescope, whose effective mass, angular resolution and wide energy coverage, will make it an ideal instrument to further this research area. The proposed analysis will provide unprecedented sensitivity to QG effects and it will open uncharted territory for new discoveries.  A planned cooperation with experts on QG will reinforce the theoretical impact of QGRANT in terms of QG models.  The Erlangen Centre for Astroparticle Physics, with its globally unique situation of hosting IceCube and ANTARES/KM3NeT groups, together with the Qu