RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimisation of cardiac differentiation from es cells : a step towards cell therapy of heart failure' (1998-2002) under Fifth Framework.

assistant: **Objectives**

It gives me pleasure to write this letter of recommendation for Mrs Evangelic Papadimou who has been a student in our postgraduate course for five years. Her work involved a systematic study of echinoid and vitamin D analogue effects on Raze P activity. The important conclusions emerged from these studies, have been published in very good international journals. Although Mrs Papadimou came to our postgraduate course with a moderate exposure to the spectrum of biochemical and cellular techniques, she very soon developed a successful effort to learn in-depth and apply most of the basic methodologies of Biochemistry and Molecular Biology. She proved herself an intelligent, enthusiastic, and hard working researcher, who has the potential to make important contributions to the field of cell differentiation. She is very knowledgeable of the literature of Basic Sciences in Medicine, a fact assuring that she will continue to keep herself updated with her new field of interest. Besides, she has a pleasant character and gets along well with other lab personnel as well as with other postgraduate students who rotate in our laboratory. According to my opinion, the host institution is a famous research centre internationally known for its contribution to the field of cell cycle regulation, cell proliferation and differentiation. Moreover, this centre is very well equipped. The requested training of Mrs Papadimou will offer her cycle opportunity to get acquainted witch the current skate of Cellular Biochemistry technology, in a new and competitive scientific environment. I have the pleasure to confirm that Mrs Evangelic Papadimou, compared with the other postgraduate students in the year, is classified in tee top 10% of the quality scale. Consequently, I warmly recommend Mrs Evangelic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'FUlly DisinteGrated private nEtworks for 5G verticals' (FUDGE-5G), addressing dissemination and exploitation.

assistant: **Impact**

FUDGE-5G aims to create a new generation of world leading 5G core network technology companies for private 5G networks based in Europe. FUDGE-5G will make a leap forward in realizing the notion of cloud-native 5G private networks by developing a further enhanced Service-Based Architecture (eSBA) for both control plane and user plane with “decomposed” players of the ecosystem divided into: New Radio (NR) access network infrastructure provider, eSBA platform provider, mobile 5G Core (5GC) provider, vertical application orchestration provider and vertical service provider. The forward-looking FUDGE-5G architecture will also feature “all-Ethernet” 5GLAN (Local Area Network), 5G-TSN (Time-Sensitive Networking), 5G-Multicast and intelligent vertical application orchestration features. The proposed framework enables highly customized cloud-native deployment of private 5G networks. FUDGE-5G will accelerate the (inevitable) shift to a fully software-based 5G core network by offering a disintegrated environment where components, both in control and user plane, can be deployed anywhere as micro-services (i.e., edge, on premises and cloud), being agnostic to the underlying infrastructure. This softwarization exposing 5G NR HW to third parties will enable the usage of off-the-shelf commodity HW to deliver additional cost savings, faster deployments and ultimately greater adoption for private networks. The consortium has been carefully built around several innovative high-tech small and medium European vendors for virtualized 5GC and service orchestration solutions and applications. They will be able to integrate, test and validate their 5G technical solutions over the premium end-to-end 5G NR facility provided by a major European MNO in several innovative use cases for private netwo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Generation of Interneuron Deficient Mouse Model', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The neural circuits underlying the formation of functional networks in the cerebral cortex constitute one of the most complex physical systems in the World. Much of this complexity arises during development through the interaction of two distinct neuronal types, glutamatergic projection neurons and gamma-aminobutyric containing (GABAergic) interneurons.Recently, interneuron dysfunction has been associated with severe neurological and psychiatric disorders (e.g. epilepsy, schizophrenia and bipolar disorder).  In order to achieve true progress in the understanding of cortical development and of neurological diseases associated with cortical dysfunction, a complete account of the development of its neuronal constituents is essential.In that sense, despite the detailed picture that is emerging about the development of cortical projection neurons, the mechanisms underlying the development of interneurons in the cerebral cortex have remained poorly defined. The general goal of this project is to obtain a comprehensive definition of the cellular and molecular mechanisms controlling the development of cortical interneurons.To reach this aim, I propose to take a multidisciplinary approach by combining mouse genetics, novel genomic applications, cutting-edge imaging techniques, and conventional cellular and molecular biology methodologies. In addition, I will develop new genetic tools to engineer developmental models of cortical disorders involving interneuron deficiency.Thus, successful execution of the project will result in:- New knowledge of the mechanisms underlying the specification, migration and differentiation of cortical interneurons, and- Generation of new developmental models of cortical disorders resulting from interneuron deficiency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Evolution, development and intentional control of imitation'.

assistant: **Concept**

The human capacity for imitation provides the foundation for language acquisition, skill learning, socialisation, and enculturation. The dominant North American model claims that imitation is innate. The EDICI project replaces this conception with a model incorporating evolutionary, developmental and cultural inputs to imitation. In the case of imitation, being human means sharing core neurocognitive mechanisms with other species, and, as a result of culture-dependent interactions during development, being unique in ones ability to harness these mechanisms for the pursuit of individual and social goals. To test a multi-level model of this kind, interdisciplinary work is essential. The consortium represents internationally leading expertise in ethology, evolu tionary biology and neurophysiology, comparative, developmental and cognitive psychology. Methods and insights from these fields will be applied in studies of children, healthy adults and neurological patients, and of animals that are closely related to hu mans phylogenetically (marmosets), ecologically (social birds) and culturally (dogs). Europe is the home of evolutionary theory, ethology and genetic epistemology, and was the site of the earliest scientific research on imitation. Our project builds on the se historical strengths by testing a distinctively European model of imitation, using world-class European facilities and expertise. We expect major breakthroughs in understanding the evolutionary, developmental, cognitive and neurological bases of imitati on, and that our integrative approach will have a broader impact on model-building in evolutionary psychology and cognitive neuroscience. In contrast with the North American conception, our model emphasises the role of experience in the development of imit ati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'TWINNING COORDINATION FOR ENHANCED SCIENTIFIC CAPACITY IN WATER QUALITY, FOOD SAFETY, TRACEABILITY, AND AUTHENTICITY BY USING INNOVATIVE APPROACHES' (SPECTRA), addressing dissemination and exploitation.

assistant: **Impact**

SPECTRA aims to improve AUTH R&I capacities to strengthen its scientific reputation, attractiveness, visibility, and networking channels. SPECTRA will stimulate scientific excellence and innovation in key research areas of Water Quality and Food Safety, Quality & Traceability (WQ&FSAT) for addressing the challenges that emanate from ongoing and accelerating climate changes in Greece. SPECTRA approach will be achieved by a unique combination of  research activities, “hands-on” training, academic and non-academic mobilities /courses and workshops on scientific and complementary transferable skills facilitated by the academic-non-academic composition of the consortium. It will reinforce R&I and knowledge transfer capacity of AUTH’s research staff, including its permanent scientists and Early-Stage Researchers (ESR), fostering collaboration between academia, industry, and stakeholders in Greece within a sustainable research framework, promoting international networking, mobility, and integration into the European Research Area (ERA). At scientific level, it is expected to enlarge the community of competitive prestigious researchers at AUTH in WQ&FSAT, stronger and better-connected to a core of international and relevant R&I systems, supported by skilled R&I managers with their international networks. At social level, it is expected an improvement in WQ&FSAT by providing new breakthrough scientific knowledge on quality of water resources, advancing food safety supervision performance, increasing consumer and market confidence in Greek food product safety, facilitating monitoring, inspections, decision-making by competent authorities, and supply chain actors and policymakers and enhancing networking, and engaging with food safety high-level experts. At an economic level, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Locally generated forces within an epithelium: how do they affect the morphogenesis and planar cell polarity?' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

My objective is to understand how localized cortical actin/myosin contractility in individual cells within the Drosophila wing hinge and wing blade combine to generate the epithelial remodelling and convergence-extension movements that occur throughout the tissue. In particular, I will examine the role of the planar cell polarity proteins in generating and/or responding to these forces and test the hypothesis that convergence-extension movements are driven by external stretching forces caused by hinge contraction. To do so, I will use a multidisciplinary approach, including both genetics and biophysics. I will combine the genetic tools of Drosophila, to manipulate gene activity in time and space, with long-term time lapse imaging and automated image analysis, developed only recently in the Eaton lab, to quantitatively describe the effects of genetically induced cortical perturbations on cell behaviour. I will myself develop a completely novel method to exert controllable forces on wing tissue in vivo by directing the production of magnetic nanoparticles in specific regions of the wing. The originality of this project lies not only in its conceptual novelty, but in the powerful combination these methods and physical modelling that will be exploited to address the problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The radiative interstellar medium' under Horizon 2020.

assistant: **Concept**

The pressure, radiation, and ionization from the warm (UV emitting) and hot (X-ray emitting) gas has a significant impact on the cold, star-forming interstellar medium. We propose to carry out a comprehensive 3D study of the turbulent, multi-phase ISM in different environments that includes, for the first time, a proper treatment of UV and X-ray emission from stellar (primary) sources and extended (secondary) sources like cooling shock fronts and evaporating clouds. We do this by means of massively parallel, high-resolution 3D simulations that capture the complex interplay of gravity, magnetic fields, feedback from massive stars (ionizing radiation, radiation pressure, stellar winds, supernovae), heating and cooling including X-rays and cosmic rays, and chemistry. We are developing a novel, original and highly efficient method to accurately treat the transfer of radiation from multiple point and extended sources in the 3D simulations. Radiation and chemistry will be coupled to achieve self-consistent heating, cooling, and ionization rates. Moreover, accurate synthetic observations covering the large dynamic range from X-rays down to radio emission will be generated to set the results in the proper observational context. This will enable us to address the key science questions: How efficient is stellar feedback in different environments and which feedback process is dominant? What is the precise role of UV radiation and X-rays, also from secondary sources? Are the observations following the key dynamical players? How do we best interpret ISM observations from ALMA, SKA, or ATHENA? How do we assist in designing future observations? With the resources requested here we will perform the most self-consistent theoretical study of the multi-phase ISM so far, thus building up a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Protecting staple crops in eastern africa: integrated approaches for ecologically based field rodent pest management.'.

assistant: **Concept**

Staple crops in eastern Africa are subject to serious pre-and post-harvest pest damage. Major losses can be attributed to rats, making them in several places the most important pre-harvest pest species. Indiscriminate use of foeticides is neither efficient nor sustainable and there is a need for ecologically based management strategies. This project will investigate the needed biological information and collect data on the economic aspects of damage and controls. Based on these data, tools for the organisation and evaluation of management strategies will be developed. Population dynamic information will be elaborated into early-warning systems and bio economic decision making models. Different approaches, not based on foeticides, will be developed and tested (seed repellents, biological control with predators, use of agro forestry).The end result will be a more sustainable, cost-effective protection of staple crops in eastern Africa.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Building a metabolic atlas of human pluripotency: dissecting the interplay between pluripotency and metabolism in human stem cells.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The naïve inner cell mass of the human embryo is characterized by unlimited developmental plasticity as it gives rise to all somatic and extraembryonic lineages. Following implantation, extraembryonic and auto inductive signals prime pluripotent cells for differentiation toward the three germ layers. Concomitantly, metabolic gene expression transits from oxidative phosphorylation towards a glycolytic metabolism. This developmental progression can be recapitulated in vitro using human pluripotent stem cells (hPSCs), a prominent tool for basic and translational research with a great impact on health and economics. Ligands of the JAK/STAT pathway are routinely used for the expansion, generation, and differentiation of naïve hPSCs. In rodents, JAK/STAT signaling controls both pluripotency gene expression and metabolism, but its role in human pluripotency is still unclear. In this project, I will unravel the contribution JAK/STAT pathway to both the transcriptional program and metabolism of human naïve pluripotency. I will study the role of metabolism during the generation, expansion, and differentiation of naïve hPSCs. Moreover, I will produce the first comprehensive computational model of hPSC metabolism to identify metabolic changes associated with human pluripotency transitions. This study is highly interdisciplinary, including scientific expertise encompassing cellular and molecular biology, biophysics, high throughput technologies, and computational biology. The wide scientific and transferable skills training provided by the host institution will allow me to achieve personal and professional maturity, crucial for an independent and competitive scientific career in Europe. The variety of the dissemination and communication measures implemented will definitively ensure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Resource hotspots and the role of apex predators in terrestrial ecosystems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Large mammalian herbivores are major ecological drivers and strongly influence ecosystem functioning. With my research program I use a resource ecological approach to understand these interactions between herbivores and the ecosystems they live in. Resource ecology is the science of trophic interactions between consumers and their resources. This CIG application describes the research line that I propose for an Assistant Professorship that I recently accepted at the Swedish University of Agricultural Sciences. I secured this position after strong international competition and an external evaluation process in which I was ranked number 1 by an international review panel. Unfortunately, the position only covers my salary and does not include start-up money to support my research. The CIG should provide this crucial start-up money. More specifically, in the proposed project I will focus on resource hotspots as an example of strong positive feedback interactions between herbivore and their plant resources. I will study the factors that modify the strength of these interactions, specifically abiotic factors and predation risk by apex predators, to understand when and where resource hotspots develop. I follow a comparative approach and propose to study consumer-resource interactions in African savannas and boreal forests. This will improve our insight in the functioning herbivore-resource interactions across terrestrial ecosystems and plant functional types. As a result, and thanks to the support of the CIG, I aim to become a leading independent scientist within the European research arena.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The formation of phytotoxic substance trichloroacetic acid - its significance for the desertification of semiarid and arid regions in southern russia and its influence on the natural resources of artic regions in northern russia.' under Fifth Framework.

assistant: **Concept**

Trides is designed to help: 1.) Achieve a better understanding of significance of the inputs of trichloro-acetic (TCA) found in the vegetation as another possible anthropogenic factor behind the ongoing de-certification observed for some 30 years in the southern Russian regions between the Caspian Sea and the Black sea.2. ) Highlight new aspects of desertification, knowledge of which in turn provide additional decision options for those with political responsibility in TCA polluted regions in southern and northern Russia . This will represent a contribution by the EU to the economic and ecological situation and thus also the security of this southern Russian region.3. ) Avert damage to associated EU states caused by the possible follow-up effects of advancing desertification, such as transnational salt/ sandstorms.4. ) Assess the ecotoxicolcxical risk for biodiversity of the natural vegetation in Artic regions affected by air pollution, and thus provide an opportunity for the regional authorities in northern Russia to identify wilderness areas which are especially threatened by TCA input and to initiate measures for their protection.