RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'REconfiguration of CONtrol in Flight for Integral Global Upset REcovery' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Commercial aircraft fault tolerant control (FTC) strategies in the flight control system (FCS) are based on fail-safe approaches whereby a nominal control law is switched first to a robust solution and then if necessary to a direct law controlling the actuators surfaces. Each component of the control law set is designed off-line and has a different level of robustness and performance. The reasons for this conservative FTC approach are:1. Lack of demonstrated maturity of reconfigurable guidance and control (G&C) methods for commercial aircraft.2. Lack of research in the practical interaction limitations between reconfigurable G&C systems and estimation / diagnostic systems.3. A definite gap on the clearance problem for such G&C systems.The goal of RECONFIGURE is to investigate and develop aircraft G&C technologies that facilitate the automated handling of off-nominal events and optimize the aircraft status and flight while maintaining, or even improving, its safety level. These technologies will extend the operation of the current G&C functionalities that assist the pilot and optimize the aircraft performance. Thus, the aim is to provoke a change in aircraft transport towards: “Full-time, all-event availability of performance-enhancement electrical fly-by-wire”This will be achieved by developing:- Advanced parameter and fault estimation/diagnosis approaches.- Reconfigurable G&C approaches.- Integration and integrated approaches for estimation, diagnosis and G&C.- Advanced clearance approaches for such systems.The investigation will focus on off-nominal/abnormal event scenarios directly affecting the aircraft flight control system. The techniques will offer the capability to adjust and adapt to the abnormal event during flight.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'The development of common user interface data analysis software dedicated to interferometric imaging'.

assistant: **Innovation**

The increasing number of telescopes in current interferometers and the dedication of new facility arrays mark the beginning of a new era in high-resolution astronomy with vastly increased sensitivity and new leaps in spatial resolution.However, taking full advantage of these new facilities will require development of common data reduction and analysis tools as well as training a new generation of astronomers in the challenging, but rewarding, aspects of optical interferometric research.Since there is no organised effort to explicitly develop software useful for all European and U.S. interferometers, this proposal would play a unique and valuable role in international Astronomy by supporting the only university-based effort to develop cross-platform" interferometry software as a community resource, the OI-LIBRARY.During the outgoing phase, the applicant will benefit from the expertise of Prof. John Monnier (University of Michigan) at first, the development of low-level data reduction routines, and then, in t he implementation of image reconstruction software as part of the OI-LIBRARY.The OI-LIBRARY will be based on the IAU-sponsored exchange data format OI-DATA and would be usable for any interferometric array. The skills gained during this first phase will be immediately applicable at the return host institution.The applicant will work on the off-line software for the MROI (Magdalena Ridge Observatory Interferometer) interferometer. Moreover, any of this development would be fully available when the imaging m ode of the European Southern Observatory VLTI becomes operational."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'All-carbon platforms for highly efficient molecular wire-coupled dye-sensitized solar cells'.

assistant: **Innovation**

The proposed project comes with a visionary approach, aiming at development of highly efficient molecular-wire charge transfer platform to be used in a novel generation thin film dye-sensitized solar cells fabricated via organic chemistry routes. The proposed technology combines the assembled dye monolayer’s, linked with organic molecular wires to semiconducting thin film deposited on optically transparent substrates. Current organic photovoltaic (OPV) cell designs made a significant step towards low cost solar cells technology, however in order to be competitive with Si and CIGs technologies, OPVs have to demonstrate long term stability and power conversion efficiencies above 10% The highest reported power conversion efficiency for OPV device based on bulk heterojunction device with PCBM and low band gap conjugated polymers is today 6.4% but this system seems reaching its limit. Offsets in the energetics of these systems lead to large internal energy losses.  The dye-sensitized solar cells (DSC) reach the efficiency above 11% but the problems with the stability of the electrolyte are the current bottleneck.  The MOLESOL comes with a novel concept of hybrid device combining the advantages of both concepts (i.e. dye coupled with organic molecular wire to a conductive electrode).  This concept will lead to stable cells with enhanced conversion efficiency based on:•Reduction of critical length for the charge collection generated in the dye monolayer by the inorganic bottom electrode, using short molecular wires compatible with exciton diffusion length.•Replacing current inorganic ITO/FTO (n-type) layer by novel transparent wide band p-type semiconductor with a possibility of engineering the surface workfunction and leading to perfect matching between HOMO of the dye layer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dissecting FOXO-mediated Transcription Noise to Stall Cellular Dysfunction in Ageing' under Horizon Europe.

assistant: **Concept**

Ageing is the result of accumulated cellular dysfunction and loss of tissue homeostasis, which often leads to the emergence of age-related pathologies such as cancer and cardiovascular disorders. The disruption of tissue homeostasis during ageing is particularly critical in the case of the vascular endothelium. The signaling interface and barrier to external factors is provided by a single layer of endothelial cells in a quiescent state. The maintenance of this quiescent state plays an important role in vascular aging and development of cardiovascular diseases. Previous studies have shown that the FOXO1 is a critical driver of endothelial quiescence, where its loss and overexpression leads to vascular overgrowth and rarefaction, respectively. My preliminary analyses show that gene expression levels of FOXO family varies in aged-tissues and that FOXO1/3/4 mutant mice display significant vascular malformation in the retina. On the other hand, ageing is associated with an increase of transcriptional noise and accumulation of aberrant RNA, which if not eliminated, may lead to cellular dysfunction. My preliminary data shows that even healthy tissues have significant levels of transcriptional noise, while old individuals present higher levels of such aberrant transcription. However, transcription noise is an unexplored phenomenon impacting cell homeostasis. In addition,  my analyses also show that FOXO1 overexpression in cultured human endothelial cells leads to higher levels of transcription noise. Given the accumulating evidence and my preliminary findings, I propose to explore how the dysregulation of FOXO transcription factors increases transcription noise, promoting functional decline of the vascular endothelium through ageing. Understanding the cascade events that drive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Artificial Cellulose Synthesizing Machinery  for Bottom-up Nanocellulose Manufacturing'.

assistant: **Concept**

Cellulose, the most abundant and renewable biopolymer on Earth, plays a critical role in numerous industries, from textiles and packaging to construction and electronics. Its exceptional mechanical strength, stability, and renewability make it a versatile material with immense potential for driving sustainable innovations. These remarkable properties are rooted in the unique hierarchical structure of cellulose and the crystalline nature of its nanofibers, termed cellulose microfibrils. Despite its importance and the fact that this material has been used since the beginning of human civilization, the intricate molecular processes behind its biosynthesis, carried out by cellulose synthase complexes, remain poorly understood. This fundamental gap of knowledge limits our ability to fully harness cellulose for advanced applications.In this project, I aim to unravel the elusive biocrystallisation mechanism of cellulose microfibrils using a material science approach. Leveraging advanced electron microscopy and molecular modelling, I will identify key physicochemical factors that control the assembly of cellulose molecules into crystalline cellulose microfibrils in natural systems. Building on the mechanistic understanding of the crystallization process, I will develop a novel synthetic platform for cellulose nanomaterial manufacturing by reconstructing the cellulose synthase complex machinery on the engineered surfaces. This approach will enable precise control over the cellulose synthase complexes’ structure and their physicochemical environment, facilitating the fabrication of cellulose nanoparticles with tuneable properties and nanoscale morphologies that surpass the capabilities of both natural biosynthesis and synthetic methods.


**Keywords:** Cellulose, Biocrystallizati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unknown functions of Osteocyte DEath' (ODE).

assistant: **Concept**

Osteocytes are long-lived cells within the bone matrix that have a variety of functions in the control of bone remodeling. They are the most frequent cells of the bone by far and mediate the regulation of the mechanical loading-induced bone renewal at the systemic level. Little is known how osteocytes die and how this process affects local bone homeostasis. Nonetheless several local bone diseases such as fracture, osteonecrosis and arthritis are characterized by enhanced osteocyte death and local bone resorption. My preliminary data show that osteocytes, when dying, undergo secondary necrosis, due to their secluded localization within the bone and the absence of phagocyting cells. Hence substantial amounts of damage-associated molecular patterns (DAMPs) are released into the bone micro-environment. I can show that DAMPs effectively osteoclast differentiation via binding to the C-type lectin receptor Mincle. My proposal ODE aims to characterize osteocyte death, the nature of the released DAMPs and the molecular link between osteocyte death and stimulation of osteoclasts. I specifically aim to delineate, in which way osteocytes die within the bone matrix (apoptosis, necrosis, necroptosis, ferroptosis or pyroptosis) and which specific DAMPs are released into the bone marrow via the canalicular network. In this context, local bone diseases such as fracture, osteonecrosis and arthritis will be investigated. In aim 1, I will molecularly characterize osteocyte cell death and block the corresponding death pathways. In aim 2, I will determine putative molecular mechanisms driving osteoclast maturation through the pathways triggered by myeloid specific C-type lectin receptors. In aim 3, I will test the molecular mechanisms of osteocyte death-induced osteoclastogenesis. Overall, m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'From the space communication to the drone industry' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Drone technology is moving extremely fast, providing different kind of services to many industries; as a result the numbers of drones for most commercial applications like agriculture spraying and seeding, mining, delivery or media was near 250,000 in 2017 and it is estimated to reach 1.5 Mill units by 2022. Nowadays, most of drone applications require flying BVLOS but current regulations limit the use of drones to VLOS (visual line of sight) or BVLOS (beyond visual line of sight) only for light drones. The state authorities, are willing to permit flights BVLOS if the pilot can prove safe operation, taking into account that 64% of the incidents between 2006 and 2016 were due to communication problems, our objective has been the creation of a satellite based communication device specially designed to improve these problems in communication links. TRANSDAT is communication system for all kind of drones flying over the aerial space. It is an innovative solution able to register and keep track on drone pilots, designed to provide location anywhere in the world, secure connection and air safety services with the highest quality standards, free from faults and interferences. It provides information to know where the drones are through a base station, tablet or even a mobile phone. This modem-type system is able to communicate position and orders, with the transmission of GPS positions to the base station while receiving commands to control both: the device and its payload. TRANSDAT was built to enable every single drone of performing a BVLOS flight that till now were limited to small ranges; it was born as a tool to improve the UAV communication and therefore security for all of us. We have performed a preliminary conservative financial forecast considering as potential addre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New Air Lifting Systems" to improve safety and performances of catamaran Ro-Ro ferries"' under Fourth Framework.

assistant: **Concept**

Project development, technical and experimental of a new Air Lifting System" able to increase safety, efficiency, comfort and speed of large catamaran Ro-Ro ferries, henceforth called "AirCat". Such a system both reduces the vessels water resistance and works as a shock-absorber. It also gives enormous advantages in safety ("AirCat" is practically unsinkable and untiltable), in comfort ("AirCat" sails on an air cushion), in cost saving (reductions in power demand and fuel consumption), in exhaust emissions and trip time (reduced to one fourth of that of conventional ferries). This system represents a significant step forward in short sea shipping for the year 2000, allowing the E.U. to become the world leader in the high speed ferry market with all the consequent economic, industrial and social benefits."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS'.

assistant: **Concept**

Our vision is to enable the world of quantum computing through an unprecedented stable and scalable many-qubit system. This platform will allow us to establish important scientific breakthroughs such as the observation of Majorana bound states, which can lead to the new field of non-Abelian many-body physics.A universal quantum computer can be exponentially faster than classical computers for certain scientific and technological applications. This long-awaited innovation can help solve many global challenges of our time related to health, energy and the climate, such as quantum chemistry problems in order to design new medicines, material property prediction for efficient energy storage, big data handling problems, needed for complexity of climate physics.Such a quantum computer has not yet been realized because of qubit fragility and qubit scalability. The output of TOPSQUAD lays the foundation for universal quantum computing with stable and scalable qubits:We will address qubit fragility by creating topological states, which are insensitive to decoherence. We will address qubit scalability by developing waferscale fabrication technology, using CMOS-compatible processes. After TOPSQUAD, existing integrated-circuit technology can then serve to scale up from individual qubits to 100,000s.These two approaches have not been combined within a single system, but our recent results show that we can be the first to address the key challenges:1. For the first time we will synthesise Ge wires on silicon wafers using scalable CMOS-compatible processes.2. We will devise an unprecedented silicon system with the required topological properties: Ge wires with a silicon shell.3. The thin Si shell will suppress metallization, thus avoiding the destruction of topological states by proxi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Specific universal immunotherapeutic method for cancer' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cancer immunotherapy has revolutionized oncology by leveraging the immune system to combat tumors. However, many cancers evade immune detection through mechanisms like the absence of recognizable antigens (Ags), limiting current therapeutic efficacy. To address this, we present OncoFlag, an innovative platform employing lipid nanoparticles (LNPs) to deliver messenger RNA (mRNA) encoding a protein of a target virus. This approach transforms tumor cells into visible targets for the immune system by inducing viral Ag expression on their surface, resulting in a revival of the immune recognition (communication) and triggering a potent anti-tumor response. Building on the results of the ERC-advanced EDISON project, which explores micro/nanoparticles as mediators for immune-cancer cell communication, we have preliminary validated this strategy in a melanoma model. Our results demonstrated significant tumor growth reduction and robust immune activation, driven by cytotoxic T lymphocyte infiltration into Ag-expressing tumors. OncoFlag Proof-of-Concept project aims to explore the viability of this platform by evaluating the universality of the therapy in diverse tumor models, as well as its versatility and translational potential. By validating the efficacy of the platform in multiple tumor types and patient-derived systems (e.g., co-cultures with primary immune cells, PBMCs), we aim to establish a novel, universal strategy that can be applied across a wide range of cancers. These studies will provide critical insights into the platform’s ability to overcome current limitations in cancer immunotherapy. By demonstrating the universality and versatility of OncoFlag, we aim to de-risk the technology, attract further investment, and accelerate its path to commercialization. OncoFlag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Deciphering the ubiquitin code of the TNF receptor signalling complex and its functional role in inflammation and immunity'.

assistant: **Concept**

Tumour necrosis factor (TNF) is a cytokine with important functions in inflammation, immunity and cancer. Signalling processes mediated by ubiquitin are crucial for TNF signalling. The seven lysine (K) residues and the N-terminus of ubiquitin can be used to form ubiquitin chains. Employing a method newly developed in our laboratory we identified the presence of four of these ubiquitin chain linkage types in the native TNF receptor signalling complex (TNF-RSC). Our knowledge of the specific functions of the different ubiquitin linkages is currently very limited. However, their presence in the TNF-RSC, combined with our recent technological advance in dissecting the composition of this protein complex with previously unreached specificity and sensitivity provides a unique opportunity for the proposed research programme: to molecularly and functionally decipher the ubiquitin code. We will aim to achieve this by studying the different ubiquitin chain linkages at the molecular level within the TNF-RSC and by determining how perturbation of specific ubiquitin linkage events impacts the physiological role of TNF in immunity to infection and its pathological function in inflammation-induced cancer.The specific objectives of this project are:•to molecularly decipher the ubiquitin code of the TNF-RSC (objective 1),•to link this code to physiological functions of TNF in immunity to infection (objective 2)•and to test its pathological impact on cancer-related inflammation (objective 3).