RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sponge diseases under climate change: a multi-omics approach to the holobiont’s molecular functions' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The Mediterranean Sea is a climate-change hotspot, which is often considered a miniature model of the world ocean. Therefore, it may allow foreseeing some of the expected global effects of climate change. Sponges hold numerous key roles in benthic ecosystems functioning. In the Mediterranean Sea, they create complex habitats serving as spawning and nursery grounds for fish and invertebrates, and their filter-feeding activity affects entire food webs and bentho-pelagic couplings. These keystone organisms are frequently suffering disease outbreaks and mass mortalities that are mostly triggered by marine heatwaves. Sponges are well-known holobionts that host complex symbiotic microbial communities.While some members of these communities offer adaptive advantages, others may contribute to disease outbreaks when environmental conditions change.This interdisciplinary research aims to discover the complex mechanism of thermal-stress-related necrosis and mortality of the sponge holobiont by studying the effect of heatwaves on the Mediterranean bath sponge Spongia officinalis through a holistic approach that includes morphological, transcriptomic, metagenomic, and metabolomic responses of the holobiont. To study causative as well as correlative disease events, the experimental setting of this project will combine in situ sampling of healthy and diseased individuals, as well as exposure of individuals kept in aquaria to simulated marine heatwaves. These will provide the first insight, not only to the change in the microbial community composition but alsoto the functionality of its members during thermal stress. It is imperative to understand the mechanism of disease prevalence and mortality and to likely suggest ways to mitigate this phenomenon. The expected increasing frequency
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Silent rotors by acoustic optimisation (SIROCCO)' (SIROCCO) under Fifth Framework.

assistant: **Objectives**

Objectives and problems to be solved:Despite the fast acceleration of wind energy implementation, wind turbine noise is still one of the major obstacles for the widespread use of wind energy in Europe. For modern large turbines, aerodynamic (in particular trailing edge) noise is considered to be the dominant noise source. The principal objective of the present project is to develop airfoils and possible other concepts, by which the aerodynamic noise of full-scale wind turbine blades can be reduced considerably (say 3-6 dB), without a reduction in power performance. The airfoils will be designed using a new combined acoustic-aerodynamic design methodology. This methodology is based on the method from the previous EU-project 'DATA' to design acoustic blades for a wind tunnel model rotor. In the present project the method will be extended for the full-scale situation. The performance of the turbines will be validated using a new measurement technique, which can localise and quantify noise sources on a rotating blade.Description of the work:The project will be carried out by a balanced consortium, which brings together the major European experience and knowledge in the required fields. The consortium consists of a major blade and leading wind turbine manufacturer, a wind energy consultancy company, and Europe's leading research institutes in the field of wind turbine acoustics and aerodynamics.The project is aimed at two different (reference) turbines, for which acoustically optimised blades will be designed, manufactured and validated in field tests. Both reference turbines are pitch controlled and have a diameter of about 60 m. The activities performed in SIROCCO can be roughly divided in the following phases. In the first phase, acoustic field measurements are carried ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '6i-DIRS: A growing attractive collaborative ecosystem for boosting impact driven research careers' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

6i-DIRS will recruit 19 qualified ESRs for high quality doctoral training to· promote their social contributions;· generate interdisciplinary, international and intersectoral projects and dissertations;· support and broaden their career prospects.Grounded on a robust, dynamic and attractive ecosystem, 6i-DIRS fosters cooperation and co-creation among 7 PhD programmes and 19 externally evaluated excellence teams, that support them with research and training around· 5 interdisciplinary platforms on EU and global challenges: Ageing and Wellbeing; Cultural and Creative Industries, Cities and Regions; Gender; Social Justice and Inclusion; and Strengthening Participation;· 4 interdisciplinary areas aligned with the Basque Smart Specialisation Strategy on Health; Sustainable Development and Innovation in Energy, Industry 4.0 and Mobility.DEUSTO has prime conditions for frequent dialogue between economic, cultural and social actors. 46 established partners and 15 co-financing entities back 6i-DIRS, ensuring international and intersectoral mobility to broaden ESRs’ employability.Recruitment will be open, merit-based, impartial, equitable and international. It will avoid any form of discrimination, with international recommendations for transparent and ethical assessment at the core and in line with the European Charter and Code of Conduct and benefiting from H2020 Gearing-Roles project on institutional change. Successful candidates will sign an employment contract, and will have shared supervision and mentoring as detailed in the Doctoral Agreement and their individual training plan.Full internationalisation is essential in 6i-DIRS, COFUND will- consolidate the rate of international ESRs (34% of PhDs in 2017/18);- help with capacity building with Eastern institutions, sharing st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeted research action on polymer materials' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

TRA ON POLYMER MATERIALS PROJECT OVERVIEWThe general aim of this Targeted Research Action (TRA) is to secure added value to EC funded research projects by helping participants in complementary projects, covering different technologies of the programme, to coordinate their activities around a specific objective. As such, the action is of importance to a wide range of industries made up of users and producers - including SMEs - as well as research centers and universities. The main objective of the TRA on Polymer Materials is to establish an efficient interface between the related RTD projects on Polymers supported by the EC.In particular the TRA aims at:- providing a European forum for the development, dissemination and exchange of scientific and technological knowledge and ideas relating to all aspects of Polymer Materials and their industrial processing;- accelerating the dissemination and exploitation of research results;- improving the synergy and coordination of research being carried out in the EC programmes;- inform EC RTD programme planners about technological trends and research needs and priorities for the future The approach to meet objectives includes the following activities to facilitate the transfer and dissemination of technology and expertise:- cluster meetings and network steering meetings and an annual TRA workshop, in which all the projects will be represented;- publication of quarterly bulletins, project database containing the non-confidential project information both as a hard copy as on disk;- publication of an annual TRA report with project achievements and the results from the workshop and meetings;- round table meetings with representatives of industry, government and society;- create opportunities and coordinate activities with related TRAns.E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rising competitiveness of early stage researchers and research management in Latvia' (RISEus2) targeting Horizon 2020.

assistant: **Abstract**

Early stage researchers (ESR) from low performing countries are less competitive in the international scientific area than ESR's form internationally-leading counterparts. This is strongly related not only to the applicants itself, but also to the environment in which they were seeded as next generation researchers - meaning Universities. The competitiveness in scientific area is related to well measurable indicators, such as impact factors, papers in high-ranking journals, H-index, competitive funding, etc. Hence RISEus2 project´s Overall Objective is to significantly strengthen the research management and administration skills of RTU RBIDC leading staff and increase the research profile of ESR hosted in RTU RBIDC in the area of biomaterials development for bone tissue replacement and regeneration based on the long-term strategic cooperation between RTU RBIDC and three internationally leading counterparts: AO Research Institute Davos, Switzerland (ARI), Institut National Polytechnique de Toulouse CIRIMAT, France (INPT-CIRIMAT) and FORM-Lab Frankfurt Orofacial Regenerative Medicine, Goethe University Frankfurt, Germany (GUF). The purpose of RISEus2 is to create links and provide training which will ensure that RTU RBIDC will gain new knowledge and approaches of biomaterials research planning, implementation and exploitation. This will include methods, tools, equipment and effective infrastructure exploitation necessary to develop excellence in biomaterials research, that will boost the cooperation with the industry, thus becoming internationally competitive and attractive. The main RISEus2 activities include two way collaborative visits, mobility of staff, summer and winter schools, workshops at partner institutions, strengthening the visibility and cooperation with ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The anatomical, physiological, and molecular basis of chronic visceral pain in humans' under Seventh Framework.

assistant: **Concept**

Chronic visceral pain (CVP) is one of the most frequent reasons for seeking health care. Pain can arise from inflammatory disease, but 50% of patients with visceral pain have no diagnostic abnormalities, and are classed as “functional”. Both types of CVP are poorly understood, but animal studies show that they involve hypersensitivity of visceral sensory nerves, and some of the molecular mechanisms of hypersensitivity are emerging. We now need a translational program which identifies molecular targets and how they change in human disease. My work has investigated structure and function of visceral sensory nerves and identified mechanisms of hypersensitivity in animal models. Now I shall test these concepts in human tissue, and thus strengthen the basic-clinical interface in the biology of visceral pain.Major questions to be addressed are:1. What functional and anatomical subtypes of sensory nerves innervate the human colon?2. Which molecular targets exist in human sensory nerves that can be modulated pharmacologically?3. How is the structure, function and pharmacology of human sensory nerves altered in disease?I shall optimise methods for working with human tissue. This involves recording of sensory nerves in vitro from surgical resections of uninflamed, inflamed or hypersensitive human colon. This will show the different subtypes and modalities of sensory nerves in the human bowel, and their specialization for specific functions in pain vs other processes. It will also test the concept I generated from animal work, that certain channels and receptors are enriched in pain sensing nerves. This work will provide insight into how pain develops in human disease. Along with functional recordings, the expression of candidate molecules on sensory endings and their structure wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MICP Applications for Geotechnical Infrastucture Concrete (MAGIC)' (MAGIC), addressing dissemination and exploitation.

assistant: **Impact**

Concrete is of fundamental importance to construction, a sector that provides 18 million jobs and makes up to 9% of EU’s GDP. It is thus not surprising that European countries invest billions of euros each year in maintaining and repairing concrete infrastructure. A major reason for concrete repair is the development of cracks, which lead to poor durability of concrete or its reinforcement. Many concrete structures are partly or fully embedded in the ground (e.g. foundations, tunnels, sheet pile walls). Detecting or repairing cracks in structures embedded in the ground is difficult; therefore, developing concretes that can self-heal/repair when cracks form is very useful for geotechnical infrastructure applications. MAGIC is an interdisciplinary project that aims to realise self-healing concrete structures for ground engineering applications,  using novel biobased processes. The techniques developed in MAGIC will be tested both in the laboratory and in the field and will be evaluated in terms of sustainability. The proposed research  addresses the environmental impact and costs of infrastructure maintenance, in line with the European Green Deal and EU priorities for decarbonisation, green and resilient civil infrastructure, resource efficiency and waste minimisation.


**Keywords:** biocements,   bioconcrete,  ground engineering,  self-healing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Genomics of cave evolution in the European olm' (GENEVOLCAV).

assistant: **Concept**

Understanding the causes of major changes of form and function of organisms is one of the big goals of evolutionary biology. Dramatic phenotypic changes happen at the transition from the surface to a subterranean life. They involve the loss of eyes and skin pigmentation, and augmentation of non-visual sensory organs. In this project I will investigate the genetic mechanisms involved in this transition, using the olm (Proteus anguinus), the largest obligate cave inhabitant, as a model organism. The olm is famous for its peculiar appearance and as a European flagship species of conservation priority. Underscoring its importance, sir David Attenborough listed it as one of ten species he would take on his personal ark to save it from extinction. The olm represents a famous example of convergent evolution at the transition from surface to caves, as already noted by Charles Darwin in his 'On the origin of species'. My overarching goal is to elucidate the genomic mechanisms involved in this transition. The specific objectives of this project are to i) reconstruct the number of independent transitions from surface to caves across all olm lineages, ii) produce a full chromosome-level assembly of the olm's genome, iii) identify the genetic and selective mechanisms associated with this transition, and iv) reconstruct the demographic history of olm lineages. This research will be made possible by combining the expertise of world-leading institutions in cave biology (University of Ljubljana) and sequencing technology (BGI- Research). Using this expertise and knowledge, I will answer a long-lasting question about the evolutionary mechanisms that drive the loss of characters. In addition, my work will contribute to the largest genome assembled for any animal species. The identificatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Virtual Library for Computer Assisted Training in Statistics' in the context of a Fifth Framework call.

assistant: **Objectives**

VL-CATS is a virtual library on Official Statistics. The project will create an Internet site with reference material and multimedia enhanced training courses on Official Statistics. In addition, a system based on groupware technology will be developed for the delivery of distance training in virtual classes or in self-study sessions. Training courses will have a fixed, modular structure that will enable easy composition of complete courses through module selection. The system will offer tools that will enable shared access to class resources in a controlled, role-based environment. The consortium comprises a systems integrator, a data analysis and modelling specialist, academic institutions and a vocational training organisation.The outcome of the project will be an Internet site hosting a distance training service that will be provided to groups or individuals. Once an infrastructure has been created for training in Official Statistics, the service will be expanded to other areas.objectivesVL-CATS objectives are:- To create a virtual library in Official Statistics with reference material, and other, publicly available statistical resources;- To develop structured electronic courses addressing areas of interest to Official Statistics;- To define and implement standards with respect to the structure of teaching material to enable compilation of complete courses out of discrete modules;- To develop a system that will host the virtual library and deliver training courses in a controlled environment enabling selective access to system resources based on user roles (tutor, student);- To develop a service for update and quality assurance of VL-CATS, furthermore, this service will enable the provision of training courses over the Internet in virtual classes;- To further devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Phenotyping of protein mechanics Libraries to unravel the design principles of catch bonds' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Mechanical forces that steer protein interactions and folding play pivotal roles in biology. They shape cellular fate, and are critical factors in both pathogen adhesion and immune response. Catch bonds, atypical interfaces that increase their bound lifetime under mechanical force, play a central role in these processes. At present, we have no model nor datasets large enough to predict if an interaction is a catch bond from its structure without doing experiments, let alone design new catch bonds.Single molecule force spectroscopy (SMFS) methods investigate the mechanics of proteins involved in these processes. These techniques typically have high force resolution, but extremely low throughput. An exhaustive database of proteins characterized by SMFS in the past 30 years contains only 85 entries. The overall aim of this proposal is to establish methods that allow large scale measurement of the mechanics of protein-protein interactions under force, first on hundreds, and finally on thousands of catch bonds: library-scale mechanical phenotyping. The key innovation proposed here is to link mechanostability, that is bond lifetime under an externally applied force, to a DNA-sequencing based readout by coupling phenotype to sequencing-readable genotype. Force resolution will be comparable to established flow-stretching assays, while throughput will increase by at least 2 orders of magnitude.The increased throughput will be leveraged to identify the design principles of catch bonds using de novo protein design. Ultimately, I aim to engineer new-to-nature de novo catch bonds with tunable lifetimes under force, which could find application in new biomaterials or as synthetic force-steered cell receptors. The interplay of design and high throughput testing will create large, hypo