RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Beatik- Collaborative Digital Scores Platform for Classical Music'.

assistant: **Objectives**

Sheet music publishers have, for years, operated a business whose added value is principally printing and selling paper; 95% of classic music being out of copyright and free to be distributed by anyone.BEATIK is a 100% paperless solution for the use and distribution of music scores. Beyond simply representing the written music on a screen, the BEATIK app features our unmatched score-following and auto-scroll technology, and includes a host of other innovative tools for interactions between musicians working together in large groups. BEATIK will provide an integrated platform and eco-system to help all musicians and the institutions they belong to, such as orchestras, conservatoires and music schools, from performance preparation to sharing annotations and score distribution. This will greatly reduce the quantity of paper used in distributing sheet music, its storage and transportation, the cost of which currently average up to €150k annually / music institution. Our solution will considerable savings for organisations with many musicians, providing a tool to supersede paper scores and the limited digital scores solutions currently on the market. We forecast sales of €7.75M in year 3, with annual profit of 5.02 (EBITDA). After €1.07 million total investment, we estimate a Return on Investment (ROI) of 7.24 three years after the completion of this Phase 2 project. About REVINCLASSICRevInClassic was established in September 2015 with the purpose of bringing digital tools into the realm of how classical musicians prepare and perform, by revolutionising their interactions with written music and managing their scores. The result is BEATIK. The RevInClassic team is a mixture of musicians, engineers and entrepreneurs, and have a close interaction with the orchestra of Spain’s p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Quantum Optics in Many-Body photonic Environments'.

assistant: **Objectives**

Quantum simulation is a fundamental concept in our pre-fault tolerant era. In this respect, waveguide quantum electrodynamics (wQED) setups, i.e., quantum emitters (atoms) interfaced with engineered photonic materials, represent promising NISQ devices for analog quantum simulation. Many experimental platforms to engineer photonic environments, e.g., arrays of superconducting circuits, possess intrinsic photonic nonlinearities in the form of photon-photon interactions caused by, e.g., the anharmonicity of the superconducting circuits. Though available for specific cases, a coherent theoretical framework to describe nonlinear many-body wQED systems is still missing. The nonlinear character of a photonic bath renders the whole system complex and not exactly solvable, making standard quantum optics textbook approaches not applicable. This project will introduce a radically new approach to this field by transferring knowledge from quantum field theory (QFT) to wQED, an approach that has already proven useful in condensed matter and in ultracold atoms physics. We will study nonlinear wQED systems, i.e., with photon-photon interactions, modelled by, e.g., a Bose-Hubbard Hamiltonian, and investigate purely photonic many-body physics effects like quantum phase transitions. This will be carried out by developing a field theory for wQED using a path integral approach, of the most powerful tools in QFT to deal with interacting fields. The central goal will be derivation of an effective emitters’ action, which can probe the many-body physics of the photonic environment. In particular, we will be able to characterize the behavior of an atomic quantum simulator across a quantum phase transition of the surrounding photonic environment. Characterizing the effects of nonlinearities repre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation'.

assistant: **Concept**

Inflammatory bowel disease (IBD) is a complex chronic pathology in western societies. There is an unmet need for new therapeutic strategies which can only be achieved through a better understanding of the molecular mechanisms of host immunity. It is established that dysregulated host innate immune recognition either caused by genetic risk variants in pathogen recognition receptor (PRR) molecules or microbial factors is commonly associated with IBD. A unique PRR family member, Nucleotide oligomerization domain (NOD)2 programs gut immunity and protection through autophagy process initiated by the recognition of microbial peptides. Deleterious mutations in NOD2 and autophagy-associated proteins are linked to IBD susceptibility. Despite the advances made in understanding of the mechanisms underlying NOD2 biology, particularly that of autophagy, very little is known about the cell signaling components and their mechanism regulating autophagy under NOD2 pathway. Recently, I discovered that a single Phosphoinositide 3-kinases (PI3K) isoform p110δ is integrated in NOD2 mediated autophagy process. PI3Ks are an evolutionarily conserved family of signaling molecules that integrate PRR signaling. PI3Ks generate lipid second messengers and regulate mediated immune responses. I now propose to unravel key biological phenomenon by which p110δ PI3K convey host protective functions through NOD2-mediated autophagy, ensuring the gut immunity and tolerance. The aims are to (1) Determine the dendritic cell-intrinsic role and mechanism(s) of action of PI3K isoforms in orchestrating anti-inflammatory processes under NOD2-mediated autophagy. (2) Discover the roles of PI3K isoforms in NLR-mediated intestinal immunity using isoform specific PI3K gene-targeted mice alongside with pharmacological t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A longudinal study of parent-child relationships and the emotional, social and identity development of children conceived by assisted procreation' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The aim of the proposed research is to follow up the families during the children's transition to adolescence as it is at this stage of development that issues of identity become salient and that parent-child conflict is most likely to occur. The research will focus on social functioning, identity development and emotional well-being of the children, as well as on the quality of parent-child relationships from the perspective of both parents and children. Data collection will take place when the children are 11 years old by administering standardised interviews and questionnaires to the mother, the father, the child and the child's teacher, to obtain multiple assessments of the parents' adjustment, the child's adjustment, and family relationships. Systematic research on the nature of the difficulties, if any, experienced by families created as a result of assisted procreation is of theoretical importance for increasing our understanding of the role of genetic ties in family functioning, of clinical importance for preparing couples embarking upon assisted procreation for parenthood, and of social and ethical importance for informing the development and integration of European policy and legislation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Microbial BIOdiversity – CLIMAte feedbacks during environmental crises in semi-enclosed basins: lessons from the Late Miocene (Messinian)' in the context of a Horizon 2020 call.

assistant: **Objectives**

The BIOCLIMA project will explore the impact of climate change on microbial biodiversity in semi-enclosed basins in order to decipher ecosystem response to environmental crises, at a temporal scale much longer than that of human life. The Late Miocene Messinian Salinity Crisis (MSC) will serve as case study. This dramatic paleoceanographic event resulted in the establishment of harsh conditions (eutrophication, hypersalinity and anoxia) at the scale of a whole marine basin, which was lethal for most eukaryotes but allowed some extremophile prokaryotes to flourish. The BIOCLIMA project will address two main aspects:1)Tempo and modes of climate variability recorded by MSC sediments. The project will investigate the sedimentary cyclicity recorded by Messinian deposits (carbonates, sulfates, and shales), which was related to climate oscillations at various time scales. 2)The microbial community structures and the modes of adaptation of the microorganisms that inhabited the paleo-Mediterranean at the advent of and during the MSC, allowing to identify the response of microbial life to climate-controlled environmental change.The project will be based on a multidisciplinary approach, applying cutting-edge sedimentological, geochemical, and geomicrobiological methods. The wider impacts of BIOCLIMA are: i) a contribution to our understanding of the biological adaptation to environmental crises; ii) establishing a catalogue of biosignatures in evaporites that will help to recognize and classify past life in ancient extreme environments on Earth and Mars.The Fellow will greatly benefit from the training in state-of-the-art methods of Organic Geochemistry and Geomicrobiology in Vienna, and increase his analytical skills in the Petrology and Geochemistry of evaporites during a second
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Representation of the 'Exotic' Body in 19th-Century English Drama', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

REBED aims at a mapping of the presence of the 'exotic' body, that is, the cultural and physical body of the non-European Other, in 19th-century English drama, with specific attention to melodramas, farces, burlesques, pantomimes and extravaganzas.  REBED aims in particular to investigate what practices and devices are employed to represent the ‘exotic’ body, to what extent the cultural, political and scientific discourses of the British Empire have influenced the dramatic representation of the ‘exotic’ body, and whether 19th-century drama was a major conveyor of racial and political values.  In addressing these questions, the project ultimately aims to verify whether 19th-century English drama contributed to the forging of a politically-oriented perception of the non-European Other, and, if so, how. It will thus provide a model for further investigation on other areas, centuries and/or genres that may be of use for the framing of contemporary perceptions of non-European minorities in Europe. Although the general frame for the project is that of Drama and Literary Studies, REBED will also widely refer to disciplines such as Visual Studies, Anthropology and History of Science.  In previous work, the researcher focused on 20th-century drama in English both from Great Britain and its colonies, as well as on the cultural and political (but not literary) background of 19th-century England. This project will allow the researcher to extend her expertise, as well as to develop a full interdisciplinary approach. The opportunity to work in a highly international context, to profit from specialized archives and the expertise of renowned experts, as well as to be able to develop complementary skills such as the management of dissemination and outreach events, will help the research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Inverse agonism. Implications for drug design' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

- The generation of constitutively active and inactive mutant receptors(CAMs and CIMs, respectively) expressed in suitable cell systems.- The generation of transgenic mice with various levels of wild type and mutant receptor expression.- The selection and testing of agonists, (neutral) antagonists, and inverse agonists with the tools under 1) and 2)- The synthesis of a set of compounds based on previously determined structure-intrinsic activity relationships and 3D receptor models.- The organisation of a consensus meeting at the end of the proposal's term provide the scientific and industrial community with a scientific rationale and evaluation of the concept of inverse agonism.G protein-coupled receptors (GPCRs) are the target in the human body for many of today' s medicines. Almost all European pharmaceutical companies market drugs that are GPCR agonists and antagonists aimed at diverse disease states such as hypertension, asthma, anxiety and depression. Current dogma is that the efficacy of these drugs is thought to be a continuum ranging from low values for competitive .antagonists to higher values for agonists. Recently, however, this experimental and theoretical concept has been firmly challenged. Under various experimental conditions antagonists may display 'negative efficacy'. Such compounds have been referred to as 'inverse agonists'.The central theme of the project (InverseA) concerns the debate whether 'inverse agonism' is to be regarded as a novel concept for the design and development of new chemical entities (NCEs) rather than as a pharmacological curiosity peculiar to genetically-engineered experimental systems. It is the participants' ambition to address this matter with the specific aim of providing a scientific rationale for the assessment of claims th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of ncRNAs in Chromatin and Transcription' in the context of a Seventh Framework call.

assistant: **Objectives**

The human genome is highly transcribed, with over 90% of sequences contributing to the production of RNA. The function of the vast majority of these RNAs is unknown. Evidence over many years has revealed that transcription factors and chromatin regulators are associated with a variety of non-coding (nc)RNAs, but their function remains largely unknown. There are a few cases where a role has been ascribed for ncRNAs in transcription, but no clear mechanistic insight has been defined yet. We predict that many of the newly identified ncRNAs emanating from the genome will play a role in transcriptional processes. We intend to identify and characterise such ncRNAs. This will take place in two phases. In the first phase we will use biochemical approaches to identify ncRNAs involved in the regulation of chromatin and transcription. Our investigations will focus on proteins leading to the induction of pluripotency and oncogenesis. ncRNAs associated with such proteins will be identified using targeted screens. In the second phase, the importance of these RNAs in determining pluripotency and oncogenesis will be analysed.  In addition, a variety of molecular approaches will be used to investigate the mechanism by which these ncRNAs regulate the function of the proteins or complexes they associate with. One particular hypothesis we will explore is that such ncRNAs play a role in guiding proteins to DNA sequences, via the formation of RNA/DNA triplexes. This concerted and focused analysis will provide mechanistic insights into the functions of ncRNAs in transcriptional regulation and validate their role in key biological processes. The identification of such new ncRNA-regulated pathways may open up new avenues for therapeutic intervention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Evolutionary consequences of novel plant defences'.

assistant: **Innovation**

Plant chemical defences play a central role in mediating interactions between plants and their enemies. Phytochemical diversity may be advantageous to reduce herbivore pressure, and plants commonly produce vast numbers of chemicals. However, the diversity of functional classes of defensive chemicals is often more limited and subject to strong phylogenetic constraints. Such functional conservatism may accelerate the evolution of tolerance in specialized herbivores, resulting in plant-herbivore systems dominated by specialists resistant to host plant defences. This presents major challenges for the study of phytochemically-mediated coevolution, as most systems lack the early stages of coevolutionary interactions that are crucially important to predict evolutionary trajectories. Occasionally however, the gain of functionally novel traits allows plants to escape their coevolved herbivores. The genus Erysimum (Brassicaceae) has gained functionally novel cardenolides in addition to ancestral glucosinolate defences, allowing it to escape several glucosinolate-adapted specialists. Making use of the unique natural and emerging molecular resources in this system, CARDEVOL will comprehensively evaluate the ecological, physiological, and evolutionary consequences of novel defences for the plant and its herbivores. CARDEVOL has four main objectives: 1) to characterize the full extent of natural variation in defence of a widespread Erysimum species and to identify environmental drivers; 2) to manipulate both defences and evaluate their contributions to plant fitness in the field; 3) to evaluate tolerance and resistance mechanisms of a community of non-adapted specialist herbivores towards the new defence; and 4), to evolve herbivores under artificial selection for increased resistanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spin effects for quantum optoelectronics' (SPIN-OPTRONICS).

assistant: **Innovation**

We propose to join the forces of ten leading European teams in order to achieve a critical mass in the new research field of Spin-Optronics, a vast novel research area at the crossroads of fundamental physics of quantum-mechanical spin, optoelectronics and nanotechnology, and establish the European leadership in this area on a world-wide scale. All three main directions of the Network research activities – growth and technology, spectroscopy and theory - will be concentrated on novel spin and light polarisation effects in nanostructures, utilising confinement of not only charges and spins, but also photons. In this field, the information is ultimately carried out by the spin of photons, can be encoded in the confined spin state and manipulated on the nano-scale and redelivered in a form of polarised photons. The four main project objectives are : 1°) Coherence of individual spin, storage of quantum information. 2°) Semiconductor entangled light sources. 3°) Interaction of free and localised spins in diluted magnetic semiconductors and hybrid structures. 4°) Spinoptronic devices based on cavity exciton polaritons. We are going to deliver a top level international level multidisciplinary training to 13 early stage researchers and 5 experienced researchers, offering them, in particular, a vast program of multinational exchanges and secondments. We will organise 4 project meetings, 3 schools and one final conference widely open to the whole scientific community. We expect this collaboration to achieve a breakthrough in establishing the fundament for the creation of new quantum devices and to overcome the existing severe fragmentation of research and training in this strategically important area, which is the main goal of our project.