RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enabling efficient cell engineering leaving gene-expression BURden OUT for cell therapies and biopharmaceutical industry' (BURnOUT), addressing dissemination and exploitation.

assistant: **Impact**

Mammalian cell engineering has emerged as a new ground-breaking modality for the development of cell based therapies to treat several hard-to-cure diseases, including cancer (T cell-based immunotherapies) and to produce molecule with diagnostic and therapeutic applications such as monoclonal antibodies (mAbs), that are now a dominant product class in the biopharmaceutical industry.  However, the pipeline for efficient design-test-commercialization of the product is long and expensive, even more so when cells must be engineered with two or more transgenes, an increasing need in T cell-based therapies or drug production (e.g., cells engineered to produce enzyme and co-enzymes, or antibody cocktails). At the core of the problem is the competition for a finite number of intracellular resources, transcriptional and translational, that cause an unbalanced expression of  products thus hampering the therapeutic effect. BURnOUT is an Artificial Intelligence and Machine Learning based software that will provide, in an automated manner, paired gene sequence optimisation to accelerate the process of mammalian cell engineering. BURnOUT will be validated in two different settings: one for the biopharmaceutics (engineered CHO cell lines for antibodies production) and one for cell therapy (engineering T cells for multiple CARs expression). The successful validation of the technology will be of trans-and multi-disciplinary interest and will have the goal of targeting the amplest variety of markets in Life Science, from AI to synthetic biology for cell and gene therapies and global cell technologies for drug industry. We envision that BURnOUT will respond to current strategic societal needs and challenges such as  reduced costs of biopharmaceutics, and more effective treatment for cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Community-driven Healthcare Access and Mental Health Promotion for Inclusive, Equitable, and Resilient European Societies'.

assistant: **Innovation**

EQUICARES supports access to innovative and sustainable mental health and care services by people in vulnerable situations through a blend of research, co-creation and policy solutions. The project uses innovative methodologies, such as an advanced application of Levesque framework for evaluation of mental health services; the deployment of Computational Social Sciences to increase access for hard-to-reach populations in vulnerable situations and collect accurate quantitative and qualitative data on inequalities in mental healthcare services; and the combination of complementary cost-analysis techniques. To unlock the design of innovative solutions, the project maps, through digital ethnography, existing innovative solutions, analyses for accessible mental health services and links them with different parts of the mental health system. Such informative insights are visualised and offered to policy makers through a dedicated Atlas. EQUICARES pilots innovative solutions in 8 areas from 7 countries, which represent diverse socioeconomic settings and cover all major categories of vulnerable groups, while informing various strategic frameworks of EU. Through “Smart Health Labs”, the project engages vulnerable groups at the community level  to co-design, implement and assess innovative solutions based on the principles of social economy and user innovation. At the individual level, the project provides awareness raising and capacity-building and pilots a novel AI-based Assistant, making advancements in the landscape of AI-generated mental health ecosystem, and fostering mental health and digital literacy of users. EQUICARES tests the value of its innovative solutions and applies novel cost analysis techniques to provide solid evidence on  the negative impact on not taking mea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'STEM AND EQUALITY, DIVERSITY AND INCLUSION: an open dialogue for research enhancement in Portugal' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The STEP project aims to enhance the scientific capacity and innovation of the consortium partners, with a principal focus on the Instituto Politécnico de Bragança (IPB, Portugal), and to raise its research profile in the field of Science, Technology, Engineering and Maths (STEM) throughout the cross-fertilisation with the Social Sciences and Humanities, in particular by introducing in the STEM domain the Equality, Diversity and Inclusion (EDI) principles, that have considerable potential in terms of solving the global challenges for wellbeing and the quality of life. The 4 internationally research-intensive leading partners in the project will accompany and guide IPB. Resources and competencies will be shared and advanced across strategic plans for improving and empowering the IPBs capacity-building focus areas.The activities targeting the researchers and administrative and managerial staff will strengthen the scientific excellence, innovation capacity (non-academia/academia collaboration), and skills for research communication and societal acceptance (social sciences and humanities, SSH involvement, in the STEM area).Activities for researchers will include mobility rounds, master classes, training, industry and SSH mentoring, attendance at conferences and workshops. This project will lead to an increased number of high-impact articles, research grants, EU projects, service contracts to the international and non-academic sectors (respectful of the EDI principles), new research topics and wide-scale impact.The Twinning Programme will gradually shift focus from research to innovation-driven implementation of the promising research outcomes.Altogether, the EU-funded STEP project will help the IPB become a regional actor for EDI/STEM innovation studies.


**Keywords:** STE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Restriction and Obviation in Scalar Expressions: the semantics and pragmatics of range markers across and throughout languages' (ROSE) under Seventh Framework.

assistant: **Objectives**

Most languages have a fairly well developed system of words for numbers, called numerals. It is cross-linguistically common, moreover, for languages to have a very rich paradigm of modifiers of such numerals. For instance, English allows the numeral ""fifty"" to be modified by comparatives (""more than 50""), (adverbial) superlatives (""at least 50""), equatives (""as many as 50""), locative prepositions (""over 50""), directional prepositions (""up to 50""), disjunctions (""50 or more"") and adverbs (""exactly 50""). As illustrated by the set of English modifiers, typically, such paradigms do not consist of specialised vocabulary but instead consist of expressions 'borrowed' from other areas of the grammar. This project sets out to use the rich vocabulary of modified numerals to make  advances in semantics and pragmatics. In particular, we will look at a subset of modifiers that have restrictions on their use, restrictions that may be obviated in specific contexts. This subset contains e.g. adverbial superlatives and directional prepositions. Accordingly, there is a semantic connection between superlativity and spatial expression that needs to be explored. More importantly, however, the found connections will clarify the nature of numerical, and more generally scalar, quantification. This is very welcome, since there is a surprising lack of insight in how we use numerical expressions to communicate quantitative information. In particular, there is no consensus as to what semantic and pragmatic processes govern the relatively simple meanings conveyed by sentences containing numerals and similarly scalar expressions. What is needed right now to break through this standstill are projects that aim at uncovering hitherto unexplored connections within language. Significant t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Molecular Enzymology of Eicosanoid synthesizing Enzymes: from mechanistic studies to rational drug design'.

assistant: **Concept**

In recent years functional genomics of eicosanoid synthesizing enzymes and molecular enzymology of these biocatalysts have become a hotspot in eicosanoid research. One reason for this switch in interest is the fact that rational drug development requires detailed knowledge on structural biology of enzymes and receptors to effectively prevent their interactions with the natural ligands.The present research project is aimed at assembling a comprehensive picture of lipoxygenase/cyclooxygenase catalysis employing dynamic models. To understand the fundamental principles of the enzymatic reaction we will combine biochemical and molecular biological approaches and use them for investigation of elementary steps of the reaction cascades with particular emphasis on the substrate binding and intra-enzyme oxygen movement.Structurally, the project can be divided into three subprojects:i) substrate binding of mammalian LOX/COX-isoforms;ii) investigations of solution structure of LOX/COX-isoforms; inter-domain movement in LOXs and its regulatory relevance;iii) structural identification of oxygen access channel(s) applying an integrated research strategy that involves molecular modelling (structural modelling and molecular dynamics) and site-directed mutagenesis.Eicosan oids and eicosanoid synthesizing enzymes have been implicated in the pathogenesis of atherosclerosis, inflammation, osteoporosis and cancer, which are of major health political relevance for all industrialized countries. Our results are expected to open new perspectives in regulation of catalytic activity of LOX/COX-isoforms providing an improved structural basis for the development of novel therapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Training network for tracking and controlling therapeutic immune cells in cancer' (T-RAFIC), addressing dissemination and exploitation.

assistant: **Impact**

Cancer immunotherapies have been established  in a growing number of clinical indications and the pace of development is massively accelerating. Currently over 6.000 clinical trials are investigating immune-related treatments in oncology especially in combinations. It includes both adoptive cellular therapies and immune modulating treatments like immune check point blockade. In contrast, the understanding of how such therapies mediate their mode of action is still mostly poorly understood. In particular, the role of distribution and relocation of immune cells after therapeutic interventions remains unknown. This is surprising, as immune cell interactions are a hallmark of therapeutic immune responses. T-RAFIC will enhance understanding of immune cell trafficking under therapeutic influence. It will open new paths and avenues to treatments, boost their efficacy and help prioritizing the plethora of immune therapeutic combinations. In the past, detailed analysis of cellular distributions was facing technical barriers. Advances in technologies, now permit tracking and visualization of cells in vitro and in vivo at an unprecedented resolution, allowing for the first time studies on immune cells under therapeutic influence. This emerging field of research has enormous potential and key importance for next generation of researchers in oncology and beyond. However, experts in this field are missing and this threats European research, development and medicine. Therefore, T-RAFIC joins forces of 19 academic and three industrial partners from nine European countries to conduct an innovative and interdisciplinary approach combining cell imaging with bioinformatics, cell engineering and clinician expertise. The network bundles recognised expertise in cancer immunotherapies, empower
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sustainable Energy Systems in Advanced Cities', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Advanced cities wants to mitigate their greenhouse gas emissions further together with local stakeholders and researchers and show how sustainable energy systems can be achieved through incorporating innovative technologies and systems. Common aims are heating and cooling shall come from renewables awailable waste heat shall be used for heating all generation of heating should be used for electricity production all new buildings and retrofitting should be energy optimised. Based on local energy analysis and EU policies, the following areas for substantial reduction of GHG has been identified and will be demonstrated in this project. A district heating system with low temperature waste heat. Design, construction and operation of energy optimised buildings. Distributed small scale co-generation in sterling engines using RES Demand side management: Individual metering and consumer initiated load control Absorption cooling using RES district heating system or solar thermal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multiphoton Voltage Imaging' in the context of a Horizon 2020 call.

assistant: **Objectives**

Understanding the brain is one of the great scientific challenges of our time. This pursuit fundamentally depends on advances in physical sciences and engineering to provide novel tools and methods to perturb, record and interpret brain activity.Information in the brain is encoded in changes in the voltage across the membrane of brain cells. Voltage imaging with genetically encoded voltage indicators (GEVIs) is a revolutionary method that allows faithful recording of the fast electrical dynamics of many genetically targeted cells in parallel. This provides an unprecedented means to record how patterns of change in this membrane voltage, called action potentials, manifest in subcellular compartments, cells, and networks across the brain, which is the only way to arrive at a fundamental understanding of brain functions like learning and memory, and of neurogenerative diseases. For this promise to be fulfilled, we need voltage imaging deep in the living brain of awake and behaving organisms. To achieve this, I will evolve a GEVI optimized for three-photon (3P) imaging, by screening mutant libraries of GEVIs directly for brightness and photostability under 3P-excitation, voltage sensitivity, and membrane trafficking in neurons. I will optimize the photocycle dynamics of GEVIs with temporally structured light, using a NOPA with tunable repetition rate, pockels cell and multiple optical delay lines, to create optimal 3P excitation protocols. Crucially, this optimization will not depend on spectral phase and is therefore compatible with high speed multiphoton imaging, aberration correction, and deep tissue imaging. Finally, I will investigate memory formation in a proof-of-principle experiment. I will use a custom microscope I developed, for 3P voltage imaging of cells in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Festival of Science European Researchers´ Night 2020 in Slovakia' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The European Researchers´ Night (ERN) in Slovakia is the biggest science popularisation event taking place every year since 2007. It is a public event aiming to bring researchers closer to  general public, showcase the diversity of science and its impact on citizens’ daily lives and stimulate interest in research careers, especially amongst young people. This annual festival of science brings together hundreds of researchers from across the country. Project will organise wide variety of activities - main online event, visits of scientists in schools, science kits, competitions, accompanying and  teasing events. The aim is to attract the general public, particularly people who are generally not interested in science


**Keywords:** science, research, innovation, EU, communication, science policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'iShare - a disruptive approach to vehicle sharing' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The sharing economy is booming globally. A PwC Analysis shows that in 2025 the sharing economy will reach the rental economy with a global value of 329 Billion dollars, an increase of 2100% from 2013. 40% of sharing-economy VC investments in unicorn startups have been directed towards smart mobility-related projects and companies. As regards as Europe, 168 million private cars are circulating in the top 5 European countries). On average, private cars remain parked 95% of their useful life and their maintenance, insurance, parking, depreciations costs significantly burden car owners. Moreover, as they mostly are parked along the roads, they massively contribute to traffic congestion. The iShare project aims to develop a disruptive approach for vehicle sharing (both B2B and B2C) enabled by a patent-pending innovative smart keyholder box (the “product”) that is capable to store the car key and push the car key buttons to open and close the car’s doors by using robotic fingers. The product is coupled with a web and a mobile app platform to manage user authentication, security, booking, payment, community management and all administrative processes related to the car’s check-in and check-out.A preliminary business plan for the first B2C market (Italy) is already available. From this starting point, the feasibility assessment will allow us to achieve three main goals:• To develop the business plans respectively for selling the product and services to consumers  and  to other peer-to-peer and b2c car sharing organizations in the EU (outside Italy) and in Americas and for the selling royalty base production licences in China and Asia Pacific;• To review, fine-tune and update the current business plan for the B2C model in Italy• To reduce the dimension and cost of the initial pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'On-line monitoring and quality control for packaged food' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This project is concerned with the development of quality control sensing technology for the food packaging industry. Modified Atmosphere Packaging (MAP) has become a widely used food preservation technique which minimally affects fresh product characteristics and hence fits in well with recent consumer trends for fresh natural and additive free food. MAP packed food is norrnally produced in an atmosphere of CO2 in this inert atrnosphere the PO2 should be less than 1% otherwise, despite a mechanically sound vacuum, undesired discolouration and food spoilage can occur leading to a product which cannot be retailed. Current methods of testing that the level of oxygen is below the required limits involve random destructive testing on the production line. This is not only wasteful but also means that packages pass through the quality checks which have too high PO2 and will later discolour and have to be rejected. If the exact PO2 could be established through a non-destructive test then not only would wastage be reduced but the shelf life of the food could be more accurately established and most likely extended, reducing wastage further. The object of the project is to develop a non destructive sensor for the analysis of the atmosphere of packaged food. The technique will measure PO2 within a food package without penetrating the package and contaminating the product. The technique will allow monitoring of each package on a production line without loss of product or production time.To achieve these objectives it is proposed to develop a novel optical sensing technology utilising the principle of luminescence quenching. The main focus of the project will be on developing the oxygen sensing technology.The research work will also focus on developing suitable oxygen sensitive memb