RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Effective and reliable optical system for cleaning validation in pharmaceuticals manufacture' (OPTI-CLEAN).

assistant: **Concept**

Cleaning validation in the pharmaceutical industry is the verification that the cleaning procedure used to remove contaminants from equipment surfaces is successfully reproducible.  In pharmaceutical manufacture, plants or individual pieces of equipment may be dedicated to individual products or indeed used in multi-product manufacture. Cleaning should be carried out as soon as practical after the end of processing and should leave the plant in a suitable condition for next use. The impact of inadequate cleaning procedures is that any of a number of contaminants may be present in the next batch manufactured on the equipment. Current cleaning validation techniques are largely based on laborious, time consuming and expensive swab sampling techniques, whereby swabs of the cleaned surface are taken and then tested using HPLC techniques in the laboratory. Equipment can be down for days, which poses enormous economic burden in the pharmaceutical industry.The proposed project will build on the promising results of preliminary research using NIR Chemical Imaging technology to detect on surfaces low concentrations of APIs and detergents used in pharmaceutical manufacture. The results have shown the feasibility of such technology to be used to provide accurate information in real-time, thereby opening up the possibility for the development of a custom-made version of the technology that could be trialled and validated for its use in the pharmaceutical industry as a cleaning validation tool. A portable imaging device will be designed and built and tested on a commonly used APIs and detergents in real pharmaceutical environments in order to validate its effectiveness and reliability. The impact of the uptake of the technology will enable rapid turn-around times, increased through-p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Risk assessment and prevention of alveolar echinococcosis (ECHINORISK)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Alveolar echinococcosis is caused by the ' fox tapeworm' Echinococcus multilocularis and is a potentially lethal disease in humans. It occurs regionally in various spots throughout Europe. Of concern are the spread of the parasite in fox populations to several European regions thought not to be endemic but also the transmission of the parasite in urban areas as well as to dogs and cats. Changes in population behaviour and migration have increased the exposure to infectious eggs of E. multilocularis and, as a consequence, the transmission risk for humans. By assessment of the status and the dynamics of transmission on a European scale the project aims to identify risk factors and to develop strategies for prevention and control. The implementation of appropriate communication tools will enable the public to achieve a realistic risk perception in different European countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Modulation of valence-based learning and behavior:  a closed-loop approach in the primate amygdala' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The primate amygdala is a neural hub that processes computations for learning and memory, specifically when learning involves emotional, motivational, and reinforcement-based signals. This requires it to remain highly adaptive for changes in valence of environments and stimuli. Failures of such computations can lead to maladaptive behaviors and even psychopathologies such as PTSD and Anxiety. However, the core principles of amygdala function continue to elude the field. Recent studies suggest valence is processed in dedicated pathways, and we do not fully understand the mechanisms governing adaptive processing of valence and its reversal. Our overarching goal here is to elucidate the factors that underlie the dynamics of valence representation in amygdala circuits, and actively reverse valence to examine the impact on behavior. We develop a new framework using brain-computer-interface (BCI) and a closed-loop approach that allows us to guide changes in neural activity in the primate amygdala and modulatory networks. We test the hypothesis that coding properties of single amygdala neurons are dynamic, and examine how adaptive flexible coding is enabled by population activity. We unveil the parameters that govern this flexibility- timescales, directionality, population size, and its effective dimensionality. We then test how reversing representation of valence alters the animal response to learned stimuli, and use it to examine and manipulate aversive-biases in models of anxiety/trauma: generalization and exploration. Using high-density neural recordings in the primate amygdala, ACC, SI, with closed-loop behavioral paradigms and computational approaches, we will unveil a more direct (rather than correlative) role for the amygdala in the process of valence-based learning, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Proposal for the Continuous Proliferation & Simultaneous Maturation of Haematopoietic Stem Cells into Blood Cell Lineages' in the context of a Seventh Framework call.

assistant: **Objectives**

Understanding the biological signals and their temporal magnitude involved in the division, maturation and migration of haematopoietic stem cells (HSCs) and their differentiated progeny would allow for a controlled continuous production of mature blood cells. By careful selection of a 3-dimensional micro-environment it is possible to mimic the niche within bone marrow in which haematopoiesis occurs. Further, by design and control of the flow profile within this microenvironment, it is possible to fine tune the rate of departure of the differentiating cells into a separate microenvironment suitable for further maturation, so creating the conditions for the generation of mature blood cells which could be a continuous process. This research will determine the requirements for the control of the fluidic behaviour within bioreactors for the generation of HSC. Complex, composite systems that allow for the temporal and spatial separation of microenvironments allowing for not only variation in the fluid flow and oxygen tension, but a change in the chemical nature of the culture conditions, will provide the opportunity for delivery of controlling factors. The principle is based on the ability to provide nutritional exchange with an overall zero, or very small, net mass transport. Mechanical design will allow us to match the rate of HSC division, providing the opportunity to derive the daughter cells into the correct environment for red blood cell development over an appropriate time frame. Differentiation of HSCs into different blood cell types occurs within different bone marrow niches and so mimicry of the erythrocyte niche is likely to result in maximisation of the rate of red blood cell development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'FILTERING FUTURES: CONTAMINANT FLOWS, LANDSCAPE GOVERNANCE AND THE MAKING OF NEW ANTHROPOLOGICAL KNOWLEDGE FOR PLANETARY HEALTH' (FILTERSCAPE) under Horizon Europe.

assistant: **Objectives**

Filtering contaminating flows in water ecologies is a critical problem for planetary health. Current approaches e.g. One Health, favour collaboration among disciplines, governmental bodies, citizens and ecological (more-than-human) actors, to innovate new thinking and sustain interventions. Despite aspirations, efforts to pull human and ecological forces into play remain obstructed by disciplinary silos, vested interests, epistemic uncertainty and a lack of a shared vocabulary.  FILTERSCAPE offers a groundbreaking research agenda for anthropology to address these limitations and drive new thinking in planetary health forward. It captures the overlooked human and more-than-human filtering work within water ecologies. Filtration is a mechanism that can mediate, exacerbate and ameliorate environmental contamination. Enacted in the relations between people, organisms and infrastructures, it works to separate and absorb wanted from unwanted matter. In doing so, it interrupts flows of contamination, to reveal their sources, effects and politics. FILTERSCAPE will analyze ecological (wetland), infrastructural (waste and water treatment) and embodied (kidneys; macroinvertebrates) filtering relations in Danish and Mexican water ecologies. By studying their histories, diagnostic capacities, governance and embodiments, this project will produce groundbreaking theoretical, methodological and empirical knowledge. It will connect the distinct subfields of medical and environmental anthropology and offer valuable insights for policy makers, practitioners and citizens. It will do this by reconceptualizing planetary health as a filtering assemblage, excavating the role it must play in shaping liveable landscapes. FILTERSCAPE provides a pluralistic, legible and collaborative platform. Anc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Structuration and properties of soft foams in food systems'.

assistant: **Objectives**

The research training area lies in the study of mousse stabilization by understanding its structuration and destabilization phenomena. Ways of innovation are exploring new systems with specific polysaccharides and/or proteins, using fundamental and applied physico-chemical properties, and developing pre-industrial formulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Carbon catabolite control in food grade Lactobacilli to provide the tools for strain improvement' (1994-1998).

assistant: **Innovation**

This project relates to studies to improve the properties of industrial Bacillus and Lactobacillus strains for the production of high- and low-molecular weight compounds. Bacteria impose regulatory mechanisms on metabolic processes in order to insure that the needs of the cell are met but not exceeded. These regulatory mechanisms interfere with the desired exhaustive industrial production of low and high- molecular weight compounds by bacteria, and with their use in food industry. The most important of these regulatory mechanisms is catabolite repression (CR) which controls carbon and nitrogen metabolism and carbon fluxes under conditions where rapidly metabolisable carbon sources are abundant. It is the aim of this project to exploit the knowledge that was gained in the previous BIOTECH programme, for the construction of novel strains of industrially important, food-grade Gram-positive bacteria that are insensitive to CR and deregulated at the enzyme level. Bacillus and Lactobacillus are chosen because they are the most important production organisms of our industrial partners. The two main goals of this proposal are i) to unravel all signalling pathways triggering CR in bacilli and lactobacilli, and ii) to construct in a predetermined way improved production strains and to determine the optimal growth conditions for the corresponding production processes. The knowledge gained about the mechanism of CR will specifically be used to improve storage properties of fermented milks with L. casei of DANONE (postacidification), to improve the production of ß-glucanase by a Bacillus production strain used by COGNIS, to optimize the fermentation of pentose sugars by lactobacilli for soy production as well as to improve the nutritive value of feed, and to construct L. casei strai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Defining the role of the FGF – autophagy axis in bone physiology' (BONEPHAGY) under Horizon 2020.

assistant: **Objectives**

Autophagy is a fundamental cellular catabolic process deputed to the degradation and recycling of a variety of intracellular materials. Autophagy plays a significant role in multiple human physio-pathological processes and is now emerging as a critical regulator of skeletal development and homeostasis. We have discovered that during postnatal development in mice, the growth factor FGF18 induces autophagy in the chondrocyte cells of the growth plate to regulate the secretion of type II collagen, a major component of cartilaginous extracellular matrix. The FGF signaling pathways play crucial roles during skeletal development and maintenance and are deregulated in many skeletal disorders.  Hence our findings may offer the unique opportunity to uncover new molecular mechanisms through which FGF pathways regulate skeletal development and maintenance and to identify new targets for the treatment of FGF-related skeletal disorders. In this grant application we propose to study the role played by the different FGF ligands and receptors on autophagy regulation and to investigate the physiological relevance of these findings in the context of skeletal growth, homeostasis and maintenance. We will also investigate the intracellular machinery that links FGF signalling pathways to the regulation of autophagy. In addition, we generated preliminary data showing an impairment of autophagy in chondrocyte models of Achondroplasia (ACH) and Thanathoporic dysplasia, two skeletal disorders caused by mutations in FGFR3. We propose to study the role of autophagy in the pathogenesis of FGFR3-related dwarfisms and explore the pharmacological modulation of autophagy as new therapeutic approach for achondroplasia. This application, which combines cell biology, mouse genetics and pharmacological app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'HETEROSUPRAMOLECULAR CHEMISTRY : an APPROACH to MODULATING THE FUNCTION of MOLECULAR DEVICES' to be submitted under Fourth Framework.

assistant: **Abstract**

The proposed research programme is of an inter-disciplinary nature capable of carrying out a particular function. One of the most exciting containing aspects of organic, inorganic and photo physical chemistry and developments in chemistry in recent years has been the search for such surface science. We believe the training aspect of this proposal to be molecular devices and evaluation of their novel application in technologies very good since the young researchers will gain experience in various such as Information storage and energy conversion. Our objective in this synthetic and instrumental techniques This will be achieved by a well project is to develop a heterosupramolecular chemistry capable of structured exchange of the post-doctoral fellows between laboratories. delivering such assemblies. In our approach we introduce an intrinsic Part of the money set aside for networking costs is targeted at this type nanocrystalline substrate as part of the supramolecular structure. The work of exchange. The young researchers will also participate in the planned contractors meetings which will be run like workshops and will be proposed is, therefore at the interface between nanotechnology and intimately involved in evaluating the progress of the project. supramolecular chemistry. The reasoning behind this approach is that molecular devices are best applied in practical devices when the Individual components can be addressed separately and this is so far not possible with solution based systems. In the project we will concentrate on the development of three prototype devices, an Optical Switch, an Optical Read-Write Device and an Artificial Leaf.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Planung und Enwicklung Logistikgerechter Komponenten zur Begutachtung und Demontage von Altautos' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The principal aim of the research project is to develop special logistic components for dismantling plants for old cars taylor-made for small and medium-sized enterprises. The project focusses on the internal material flow of bodies, components, materials and recyclings, on handling and material flow-related design of dismantling isles as well as on a more flexible and rational check of old cars in the plant's entry zone. In this respect the modular structure of these components is of special importance; it grants the SME optimal flexibility concerning adaptation to a variety of types, dismantling capacity, spacial situation and available investment means. The results of the FTE activities should lead to the building of demonstration objects and be made available to SME in order to improve their competitiveness in the automotive industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Autonomous Indoor  Outdoor SafetyTracking system' (AIOSAT), addressing dissemination and exploitation.

assistant: **Impact**

The Europe population experiences yearly about 2 million to 2.5 million fires with 20 to 25 thousand deaths and 250 to 500 thousand reported injuries. Moreover, EUFireAcademy states European countries suffered 558 fatalities per million inhabitants due to fire hazards during the year 2010.Even though satellite-based positioning technology allows rescue workers to already operate efficiently, GPS availability, reliability, and accuracy are often poor during fire operations, for example due to thick smoke, dense forests, rough terrain and inside buildings. In this context, the objective of AIOSAT (Autonomous Indoor & Outdoor Safety Tracking System) is to progress beyond the state of the art by defining the AIOSAT concept that aims to overcome aforementioned limitations of GNSS usage in rescue interventions. For this purpose, GNSS positions are enhanced with EGNOS and fused with position information inferred from IMU and RF.The main paths to the goal will be to define 1) the end-user requirements for the AIOSAT system, 2) the Advanced Positioning Subsystem 3) the Communications Subsystem 4) the tracking and alerting (TA) application and, 5) build an integrated prototype system validated during field tests. The dissemination and use of the project outcomes are the ultimate objective. Therefore, in order to use and spread the knowledge acquired, a set of concrete, quantitative and customized activities is planned. The main strengths of the AIOSAT consortium are threefold.1) It is composed of world class organizations with extensive and successful prior experience in the research topics related to the technologies employed. 2) The consortium involves two end-users, a technology provider, a university, a university-level military academy and two SMEs aiming at exploiting the p