RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Power of Randomization in Uncertain Environments' (UncertainENV) under Horizon 2020.

assistant: **Objectives**

Much of the research on the foundations of graph algorithms is carried out under the assumption that the algorithm has full knowledge of the input data.In spite of the theoretical appeal and simplicity of this setting, the assumption that the algorithm has full knowledge does not always hold.Indeed uncertainty and partial knowledge arise in many settings.One example is where the data is very large, in which case even reading the entire data once is infeasible, and sampling is required.Another example is  where data changes occur over time (e.g., social networks where information is fluid).A third example is where processing of the data is distributed over computation nodes, and each node has only local information.Randomization is a powerful tool in the classic setting of graph algorithms with full knowledge and is often used to simplify the algorithm and to speed-up its running time.However, physical computers are deterministic machines, and obtaining true randomness can be a hard task to achieve.Therefore, a central line of research is focused on the derandomization of algorithms that relies on randomness.The challenge of derandomization also arise in settings where the algorithm has some degree of uncertainty.In fact, in many cases of uncertainty the challenge and motivation of derandomization is even stronger.Randomization by itself adds another layer of uncertainty, because different results may be attained in different runs of the algorithm.In addition, in many cases of uncertainty randomization often comes with additional assumptions on the model itself, and therefore weaken the guarantees of the algorithm.In this proposal I will investigate the power of randomization in uncertain environments.I will focus on two fundamental areas of graph algorithms with uncerta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'From GWAS to functional studies: Tackling the complex nature of brain disorders'.

assistant: **Objectives**

Genome-wide association studies (GWAS) of unprecedented sample size have recently provided robust insight into the polygenic architecture of many different brain disorders. Despite this exciting potential, GWAS results have rarely translated into mechanistic disease insight. This is because the detected genetic effects are small and numerous, and hardly ever directly actionable for functional follow-up. In addition, the polygenic nature of brain disorders comes with large genetic heterogeneity, where different patients with the same disorder may carry completely different combinations of genetic risk variants, possibly corresponding to different etiological mechanisms, requiring different treatment regimens.  To benefit from GWAS, extensive biological interpretation and insight into genetic heterogeneity is needed. In this ERC I will develop much needed tools for (i) extensive biological interpretation at cellular resolution and (ii) assessing genetic heterogeneity, both aimed at formulating hypotheses that take into account the polygenic nature of brain disorders and can be tested in functional experiments. I will apply the developed tools to a wide range of brain-related traits, providing ample starting points for functional follow-up. As a proof-of-concept I will test the viability of two neuroscientific approaches (iPSC and DREADDs) for functional follow-up of GWAS results. First, I will conduct scRNA sequencing and electrophysiological assessments on iPSC derived neurons and astrocytes from genetically selected (schizophrenia) patients and controls. Second, I will use in vivo chemogenetic manipulation to target specific cell types that have been implicated by GWAS (for insomnia). The primary goal of this proposal is to bridge the gap between GWAS and function. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enantioselective N-α C(sp3)-H Functionalization of Amides by Trifunctional Catalytic Systems' to be submitted under Horizon Europe.

assistant: **Abstract**

The trifunctional catalytic systems (TCS) consisting of bifunctional photocatalysts and transition metals will be designed to achieve the enantioselective N- C(sp3)-H functionalization of amides (ENCHFA). Mechanistically, the bifunctional chiral hydrogen bonding-based aryl ketones will activate the amides to form -amido radicals via HAT and control their reactivity in an enantioselective manner while transition metal will provide another opportunity to active substrates and accomplish the photocatalytic cycle via a radical relay.  Combining chiral hydrogen bonding-based aryl ketones with Co catalysis, the protocol will develop the external oxidant-free enantioselective N- C-H alkenylation, arylation and alkoxylation of amides with H2 evolution. Furthermore, the enantioselective N- C-H trifluoromethylation of amides will be relized by merging chiral hydrogen bonding-based aryl ketones with Cu catalysis. The trifunctional catalytic systems will not only enrich the types of enantioselective C-H functionalization of amides, but also reveal the mechanism of trifunctional catalytic systems, as well as provide guidance for designing multiple systems in asymmetric catalysis.


**Keywords:** Photocatalysis, Enantioselectivity,  Radicals, Hydrogen atom transfer, Transition metal catalysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Global architecture for multimedia action' to be submitted under Fourth Framework.

assistant: **Abstract**

The objective of the project is to create a satellite-based infrastructure that will allow the European and Japanese users to exploit the connectivity created for the development and trial of new applications. A further objective is to introduce non-GAMMA applications with a Europe-Japan aspiration to the use of the satellite network.It is anticipated that satellite capacity will become available in April 1997 and will be continuously available on a 24 hour basis for at least one year. However, it is anticipated that the satellite will be needed for some months in mid 1998 and steps to realise this will be taken. The nominal date for termination of the work of GAMMA is end December 1998.Expected ImpactThe concept of the information superhighway has raised expectations amongst both users and providers of network applications. These expectations can only be effectively and economically met if we can overcome obstacles to the use of wide area broadband communications. The GAMMA project provides support to the resolution of these questions precisely because:it is focused on the international aspect of interconnection agreements;it will verify that applications can work transparently in a mixed terrestrial-satellite environment;it will disseminate results widely to interested parties in the world of telecommunications and R&D.Main contributions to the programme objectives:Main deliverablesGAMMA used a satellite to connect European and Japanese researchers so that they could develop and test new applications over an ATM infrastructure.Contribution to the programmeThe global village is brought together by high speed connections over optical fibre or satellite links.Technical ApproachGAMMA will create a facility that links various ACTS and Telematics Platforms as well as non-Eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'From Typhoid Fever to Antimicrobial Mechanisms' (TYPHI) targeting Horizon 2020.

assistant: **Abstract**

This programme will identify critical host mechanisms that kill bacterial pathogens by exploring a novel mammalian antimicrobial pathway, which I discovered.  This pathway protects non-susceptible hosts from typhoid fever.  Typhoid fever is caused by Salmonella Typhi, a unique intracellular pathogen that kills more than 200,000 humans per year.  Yet, Salmonella Typhi does not infect other mammalian species, such as mice.  An understanding of the mechanisms that protect mice from Salmonella Typhi infection will enable me to determine how Salmonella Typhi circumvents these protective mechanisms in humans to cause fatal disease.  I have demonstrated that the mechanisms protecting mice are based on an intracellular trafficking process regulated by the Rab32 GTPase.  The following critical questions will be addressed:1) What killing molecules does the Rab32-dependent trafficking pathway deliver to the Salmonella Typhi vacuole?2) How is the Rab32-dependent trafficking pathway regulated?3) Is the Rab32-dependent trafficking pathway active in human macrophages?  And if so, how does Salmonella Typhi evade killing to replicate in human macrophages?I will define the antimicrobial mechanisms responsible for killing Salmonella Typhi and other bacterial pathogens by exploiting a powerful combination of functional genomics, cutting-edge “omic” approaches and versatile screens.  This ambitious, high-gain programme will:I) Identify novel antimicrobial molecules that kill bacterial pathogens;II) Identify critical regulators of this novel antimicrobial pathway;III) Elucidate how Salmonella Typhi establishes deadly infections in humans and identify new therapeutic targets.The overall objective of this programme is to improve global health by capitalising on novel mechanisms of host defence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'VIDEOGRAPHY OF ULTRAFAST PHENOMENA USING THE FRAME CONCEPT' (ULTRA-FAST).

assistant: **Innovation**

Scientists have always been particularly intrigued by the extremes in nature and made significant efforts to study these; microscopes allow us to observe the smallest objects, while telescopes permit us to explore the largest objects and also those farthest away. The work proposed herein will provide new means and generate insights to phenomena occurring on the shortest timescales in nature.Past methods to probe ultrafast events – occurring on picosecond timescale or faster – have mostly relied on pump/probe scanning, yet these can only measure the dynamics of such processes if they are repetitive. Understanding all spatiotemporal aspects of ultrafast phenomena, however, requires experimental means to spatially, spectrally and temporally resolve them. Recently the PI invented a “coding” imaging concept called Frequency Recognition Algorithm for Multiple Exposures (FRAME) that can film at up to 5 trillion frames per second. To date, FRAME is the only videography method that can unify a femtosecond temporal resolution with spectroscopic compatibility, making it a powerful tool with high potential for new scientific discoveries. This project aims to (i) develop novel diagnostic tools based on FRAME and (ii) apply FRAME videography to study ultrafast events, whose temporal evolution could not be visualized in the past.Ultrafast science is a wide field, making the project highly interdisciplinary. For example, within photo-physics, systems will be developed to film plasmas and laser filaments. Diagnostics will be developed to image the lifetime of coherent states as well as fluorescence decays of two fluorophores in parallel, which holds potential within biology, physics and chemistry. A two-color FRAME setup will be developed to temporally track the creation and consumption
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Thermodynamic, kinetic and modelling studies on the interactions of chitosan and metal ions' in the context of a Sixth Framework call.

assistant: **Objectives**

This project is directed to the development of kinetic, thermodynamic and modelling studies on the interaction of chitosan and metal ions. Chitin will be obtained from different sources aiming to isolate alfa-chitin and beta-chitin. Highly deacetylated chitosans will be prepared by carrying out the deacetylation reactions of chitin.Depolymerized chitosan and chitoolisacharides will be prepared by the controlled depolymerization of the chitosan samples, to determine the dependence of their complexation properties on the average molecular weight. These samples will be processed in different physical forms aiming the preparation of materials having high specific superficial areas.All the samples of chitosan and chitooligosaccharides as well as the corresponding materials processed in different physical forms will be characterized in terms of their chemical structures and dimensions. These materials will be employed to study the kinetics and thermodynamic aspects of the interaction involving chitosan or chitooligosaccharides and metal ions of cadmium and cooper.It will be also important to determine the predominant ionic species of each metal as a function of the pH in the optimal conditions of complexation. The main objective is the determination of the chitosan/metal ion complexation constants and the thermodynamic and kinetic parameters corresponding to enthalpy, entropy and activation energy.The characteristics of the chitosan/metal ion complexes, including the physical form, chemical structure, morphology and crystallinity, will be determined. Some properties of the chitosan/metal ion complexes, such as their thermal stability, will be also investigated.The molecular modelling studies aiming the determination of the geometry of the chitosan/metal ion complexes will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sustainable Architecture Applied to Replicable Public-Access Buildings' (SARA) targeting Sixth Framework.

assistant: **Abstract**

SARA aims to construct sustainable, cost effective, high-energy performance, public-access eco-buildings that are immediately replicable at large scale in many locations. The eco-buildings will be equipped with advanced sustainable energy technologies integrated by an innovative architectural approach and combined monitoring and building management systems, BMS.Given that public-access buildings tend to have relatively intense energy consumption the overall impact in terms of absolute energy savings and pollution reduction will be particularly significant. SARA involves the demonstration of 8 highly sustainable and replicable Public-access buildings in 5 EC Member States (A, E, F, I, UK), 2 EC Candidate countries (PL, SI) and 1 New Independent State (UZ). There are 16 participants in the project: the promoters and research organisations of the countries involved in the 8 countries of demonstration plus research and technical development (RTD) from Germany.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A fully wearable electro-stimulating system designed to improve mobility and foot health in diabetic peripheral neuropathy patients' in the context of a Horizon Europe call.

assistant: **Objectives**

The NEURO-SOCK is a non-invasive, fully-wearable device designed to induce sensations in patients with sensory loss due to conditions such as amputation, diabetes, or multiple sclerosis. The device captures information from the environment interaction through wearable sensors and translates it into electrical impulses delivered to the nerves embedded in a soft-robotic stimulating garment. An AI-based algorithm optimizes stimulation parameters to target the nerves and restore natural sensation to patients in real-time. Our device has been already validated in 12 neuropathy patients, resulting in 30% restoration of lost sensation in the foot and in an improved cadence in 60% of the users. The generated artificial feedback intuitiveness was validated through an fMRI study. This ERC-funded project aims to investigate the health benefits of NEURO-SOCK, with the potential to improve skin conditions, lower cardiovascular stress, and ultimately reduce the harmful conditions that lead to sedentary lifestyle, heart failures, amputations, and elevated death rates. Therefore the funding will be used for optimizing the NEURO-SOCK design for home-use scenarios and a following clinical trial investigating the long-term rehabilitative effects on people suffering from neuropathy, who currently have no immediate solution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Icevoltaics: from the Workman-Reynolds Freezing Potentials to Electrical Energy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Water and aqueous solutions release a huge amount of thermal energy during freezing. Accessing energy utilizing the freezing process has never been attempted until today. It is known that orderly freezing of dilute aqueous solutions can result in electrical potentials as great as 230 volts at the ice-solution interface, namely the Workman-Reynolds freezing potential (WRFP), and a maximal electrical current of 1 µA. Based on our newly published results of counter ion separation during icing growth in ionic liquids, this project aims to combine high-throughput computing and nanotechnology for probing the approach of controlling and utilizing stable WRFPs and for the first time to enable energy exploration in the freezing process of aqueous solutions. Specifically, ionic liquids will be screened for maximizing WRFP and electrical energy output via atomistic modeling and multiscale experiments. Critical parameters for WRFP, including ion concentration, temperature and freezing rate, will be investigated for their effects in electrical energy generation. Novel electrical energy output based on WRFP will be constructed and tested, which will seed an entirely new green energy acquisition research and application field. The project, termed Icevoltaics, explores an un-touched energy source and provides highly innovative solutions of the future and clean energy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Energy-Efficient Multi-Terabit/s Photonic Interconnects'.

assistant: **Objectives**

The rapid growth of data traffic requires radically new approaches for high-speed data transmission to increase the bandwidth and power efficiency by orders of magnitude. The proposed research aims at novel system and device concepts for low-energy high-capacity optical interconnects in data centers. Data rates of 10 Tbit/s and beyond are envisaged by coherent multicarrier transmission. Parametric frequency conversion in high-Q Kerr-nonlinear resonators will be used to generate broadband combs of frequency-locked optical carriers. Integrated silicon photonic systems will allow for power-efficient multichannel modulation and detection. Novel reconfigurable optical signal processors will avoid excessive digital post-processing and hence reduce overall energy consumption.