RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tolerance Restoration In Autoimmune Diseases by selective manipulation of the CD28 costimulatory pathway' to be submitted under Seventh Framework.

assistant: **Abstract**

The TRIAD, Tolerance Restoration In Autoimmune Disease, consortium provides an innovative strategy to autoimmune diseases (AID) therapy, based on antibody approach with a well established mechanism of action. The main objective is the evaluation of a selective antagonist of CD28 to prevent, treat and/or cure some AIDs in preclinical models including rheumatoid arthritis, multiple sclerosis, type 1 diabetes, psoriasis, uveitis and arteriosclerosis.The concept is based on rather than suppressing the immune system as a whole, suppressing only the parts of the immune system responsible for the autoimmune attack, while sparing and enhancing regulatory T cells. Costimulation through the CD28/B7/CTLA-4 molecular triad controls the balance effector/regulatory functions after initial antigen exposure. An antagonist anti-CD28 represents a novel drug candidate allowing very specific immunosuppression compatible with regulatory T cells function, immune regulation and therefore tolerance induction/restoration.The TRIAD project will start with the study of the efficacy of a new selective antagonist of CD28 in non-human primate models and the exploration of the potential efficacy of surrogate CD28 antagonist in rodent models. Then will be performed an evaluation of potential immunological toxicity of the antagonist in humanized SCID mice and non-human primate, to exclude agonist activity in vivo. Previously identified mechanisms of action (i.e. costimulation blockade and induction of Tregs) in the context of AID will be confirmed in experimental models. Formulation and preclinical toxicological studies will be run before initiating PhaseI/II trial in patients.TRIAD capitalises on the strong experience available in Brazil and Europe in the field of immunology. It comprises 6 academic i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New chemical and biochemical sensors for analysis of food, enviromental and medical samples' to be submitted under Sixth Framework.

assistant: **Abstract**

Intensive development of science and technology brought longevity and standard of living but paradoxically generated also new threats to human health. It is jeopardised by chemical compounds, both organic and inorganic, found in waste by-products of numerous technological processes. Moreover, daily use pharmaceuticals and pesticides introduced into food chain and their biological change by-products may have a negative impact on human life and environment. Therefore it is vital to formulate an integrated natural environment control system allowing its continuous monitoring and facilitating observation of movement of toxic and potentially toxic compounds in the environment, tracing how they are incorporated into the food chain and enabling their chemical analysis. To achieve this aim is necessary to develop new analytical methods, which should be easy to implement and have low exploitation costs in order to be used widely in less affluent countries.The main purpose of this project is the formulation of innovative tools for quick determination of hazardous components in food, water and soil. Tools will be designed to work as sensors of electrochemical modes of operation. Low cost, quick analysis and miniaturisation of analytical equipment justify such selection. The working mechanism of proposed sensors is based on the interface intermolecular recognition processes. Thus, designing new sensors will be connected with receptor's synthesis in order to obtain sensing materials which will be able selectively recognised target molecules at very low concentration levels by interaction of receptor-substrate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Euro-Qual II Programme' under Fourth Framework.

assistant: **Concept**

EURO-QUAL II envisages the encouragement of basic and applied research on methodologies that improve quality of orthodontic care in Europe, as well as the harmonization and implementation of these methodologies in European Member States. On a side track of this mission, EURO-QUAL's intention is to support related specialist-branches in their development and implementation of pan European quality initiatives by exchange and communication of knowledge and experience of models for assessment of health needs and demands, and for trendsetting and planning in the field of public health. This includes further cooperation with Eastern European colleagues that have been associated with EURO-QUAL during the past yearObjective 1 : Consolidation, implementation and expansion of the established framework of guidelines for effective and efficient orthodontic care in Europe, through harmonization of strategies for improving the quality of orthodontic care and the establishment of a quality culture in European memberstates. During the First European Consensus Meeting on Orthodontic Care" it has become apparent that in a substantial number of the participating countries, national quality initiatives are taken. EURO-QUAL II strives to bring together these initiatives on a European level with the aim of exchanging information and expertise. This will be achieved by the establishment of a transnational platform of orthodontic quality experts who have experience with working on quality initiatives on a national level. Objective 2 : Assessment of the socio-economic impact and performance measurements of orthodontic provision through development and implementation of an orthodontic quality information system, in cooperation with existing telematic systems in oral health care. Main objective i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cryogenic Electronics for Space Applications and Research' under Seventh Framework.

assistant: **Concept**

Observations from space offer huge improvements in many fields of science. They expand widely the range of the spectral information compared to ground applications. Recently, the use of space qualified cryocoolers to decrease the temperature of instruments down to few kelvins and even below, allows the use of new resistive sensors exhibiting outstanding performances when compared to classical devices. For example, new moderately cooled magnetometers arrays can provide a very high magnetic sensitivity for space exploration, thermal X-ray detectors can reach a spectral resolution two orders of magnitude better than Silicon ones, and in the Infrared domain, observations with bolometers will soon be limited only by the photon background of zodiacal light.The development of large format array detectors in these three fields is today constrained by the amount of signal channels that can be extracted in parallel from the power limited cold stages.The goal of this network is to provide the community with cryogenic electronic elements performing all the essential functions to preserve the signal quality of a large amount of sensors (pixels). For this purpose, two ways must be followed in parallel:-the development of new components (transistors) showing low noise and reduced power consumption to replace the JFETs limited to 120 K-the conception of new circuits based on the cryogenic proven CMOS and SiGe technologies to realize complex functions (amplification, filtering, multiplexing and digitalization…)The network gathers fundamental solid-state research laboratories for the development of elementary electronic components; a semi-industrial company already manufacturing complex CMOS and SiGe circuits for cryogenic space applications (Herschel), specialists of cryogenic measureme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Uncooled Nanopillar Single-Photon Avalanche Diodes (NP-SPADs) at Telecommunication Wavelengths' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

High efficiency detection of single photons at telecommunication wavelengths (notably at 1.55 µm) is critical for emerging technologies, such as free-space and on-fiber quantum information processing, eye-safe and long-distance light detection and ranging (LiDAR), and highly sensitive remote sensing. This research project aims to meet this critical need by developing III-V nanopillar-based uncooled single-photon avalanche diodes (NP-SPADs), which are composed of nanostructured InAsP-InP Geiger-mode avalanche photodiodes (GmAPDs) with self-assembled plasmonic gratings, operating at 1.55 µm. Compared with commercially available InGaAs(P)-InP GmAPDs, the proposed device scheme significantly suppresses thermally generated carriers and trap state population by a factor of 20 to 100 due to the extremely small fill factor of nanopillar arrays (less than 5%). All the while, sufficient optical absorption is maintained via surface plasmon resonance by the plasmonic gratings. The sum combination of these unique capabilities offers the promise of achieving NP-SPADs with free-running mode operation, high photon detection efficiency (PDE; probability of detecting a single photon) of 10 – 20%, low dark count rate (DCR; rate of false detection) of ~50 Hz, and high photon count rate ≥5 MHz. If successful, this approach can drastically stimulate the development and commercialization of high performance semiconductor-based NP-SPADs, putting European Union (EU) at the forefront of cutting-edge technology in single photon detection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'greenREF - Development of reference standards for the analysis of chlorinated paraffins' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Chlorinated Paraffins (CP) are considered as Persistent Organic Pollutants (POP). Although the short chain CPs (SCCPs) have been banned on a global level the production of CPs is alarmingly large (2m tons/yr.). Being persistent, CPs stay in the environment for decades. Their greatest threats are their high potential for bioaccumulation and carcinogenic potential to humans and other mammals. Unfortunately, CPs are found in a great deal of applications, including plasticizers, flame retardants and metal working fluids, causing potential exposure.A significant challenge concerning CPs is the considerable lack of effective and generally accepted reference standards, which means that the identification and quantification of CPs are currently sub-standard. These deficient analytical methods do not provide the needed precision for meaningful analysis and monitoring of CP presence in e.g. water, soil and foodstuff.At Chiron we are experts in the preparation of standards for chemical and biological analysis and in the development of 13C-labelled Certified Reference Materials (CRM), especially focussed on forensic toxicology and biomarkers for various applications (e.g. environmental and geochemical analysis). We wish to use our knowledgebase to develop a CP CRM production platform which includes pure native standards, 13C labelled CPs, and new analysis methods for the quantification of CPs. This will have considerable impact within environmental toxicology by empowering analysts to provide detailed and meaningful analyses of CP presence in the environment, allowing for greater monitoring and control.Since the specific CP expertise does not currently exist in-house, Chiron will need to employ an Innovation Associate through the Innovation Associate Program, who with his/her capab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'deepHelix: a massively scalable, AI-powered peptide drug discovery platform' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Peptide drugs potentially address limitations of both small molecules and antibodies. Small molecules struggle to target protein-protein interactions (PPIs), while antibodies cannot access intracellular proteins.  In this project we will develop an AI-driven experimental platform to produce cell-permeable therapeutic peptides made entirely of natural amino acids. The platform will allow the rapid discovery of cost-effective, stable, cell-permeable, and high-affinity peptide binders for use as research tools, in diagnostics, and as therapeutics against intracellular proteins previously considered undruggable targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Highly efficient & flexible remote welding systems for advanced welded structures' (REMOWELD) under Fifth Framework.

assistant: **Objectives**

The Project aims to an extended, sustainable and competitive use of remote laser welding systems promoting the development of competitive manufacturing procedures able to: reduce the requirements for assembly; increase up-gradability, flexibility and recovery of production equipment; shorten the design and the ramp up production time 'and TTM) by 20-30%; reduce the investments (up to 50%); make economically feasible, sustainable and eco-compatible an extended use of laser technologies. The Work-plan is mainly addressed to: define the industrial end users expectation; adapt and assess the remote welding techniques for two different applications integrating, within innovative production systems, advanced highly efficient remote welding systems including miniaturised high power scanning and assisting devices.The project has developed and successfully tested two independent prototypes of a video content management system with advanced functionalities. The Commercial PRIMAVERA system integrates·A image similarity search engine capable to search 1.3 millions of key frames within 3 seconds·A conceptual search engine capable to search images within 4 categories and 8 attributed·An advanced video analysis and indexing service capable of abstracting videos·A Relevance Sphere visualization to display complex search results·3D Infoscape visualization of Image search results under a common, easy to use, web based interface.The Scientific PRIMAVERA system goes beyond this. It integrates all the features of the commercial system and adds collaborative and knowledge-sharing technologies such as·a user profiling and filtering system·a knowledge sharing tool·a team based and task oriented project management.Both systems have been installed at a broadcasters archive and tested with large
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Centre of Excellence in Production Informatics and Control'.

assistant: **Objectives**

The main, overall objective of the proposal is to establish the Centre of Excellence in Production Informaticsand Control (EPIC) as a leading, internationally acknowledged focus point in the field of productioninformatics, management and control representing excellence in R&D&I. EPIC will be constituted and runthrough the cooperation of the Institute for Computer Science and Control, Hungarian Academy of Sciences(MTA SZTAKI), two faculties of the Budapest University of Technology and Economics (BME) and fourinstitutions of the Fraunhofer-Gesellschaft (FhG) under the coordination of the National Innovation Office(NIH), Hungary as a governmental decision maker.The EPIC project will lead to:1. The upgrade of MTA SZTAKI as existing Centre of Excellence of the EU.2. The further development of the Fraunhofer-SZTAKI Project Centre for Production Management andInformatics (PMI), a joint initiative of FhG and the Hungarian Academy of Sciences (MTA), establishedin 2010. (The cooperating Fraunhofer institutions have been the Fraunhofer Institute for ManufacturingEngineering and Automation (IPA), Stuttgart and Fraunhofer Austria (FhA)).3. The extension of the present cooperation with two faculties of BME, i.e., the Faculty of MechanicalEngineering (GPK) and the Faculty of Transportation Engineering and Vehicle Engineering (KJK), onthe one hand, and with two additional institutes of FhG, i.e., the Institute for Production Technology(IPT), Aachen and the Institute for Production Systems and Design Technology (IPK), Berlin.4. The close cooperation with SMEs as well as with large industrial firms.Due to direct, institutionalized and supported interactions with Fraunhofer, not only the scientific capabilitiesof the Hungarian partners but also their ability to transfer scientific results
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional analysis of acta, a bacterial protein involved in actin-based mobility' under Fourth Framework.

assistant: **Concept**

Listeria monocytogenes is an intracellular human pathogen. It uses actin and other actin- associated proteins to move through the host cell cytoplasm. The surface protein ActA is the sole listerial factor needed for recruitment of host cell actin. It is polarly distributed on the bacterial surface. To identify the structural features of ActA crucial for activity and its polarized distribution I plan to: - perform deletions and point mutation analysis of different domains of ActA, followed by the analysis of the mutants in infected cells or in cytoplasmic extracts. - analyse if there is a specific sequence in ActA which serves as a targeting signal for its polar distribution.  The results of this project will help us to understand actin-based bacterial motility, a phenomenon which plays a crucial role in the dissemination of Listeria monocytogenes in the liver.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Neural decisions under uncertainty' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Virtually anything we sense, think and do is uncertain. For instance, when driving a car, you often need to determine how close you are to the car in front of you. It is near impossible to estimate this distance with absolute certainty – but it is possible to guess and even to estimate the uncertainty associated with that guess. Accordingly, we reduce speed when driving at night, because we realize perceived distance is more uncertain in the dark than on a sunny, clear day. How do we infer that visual information is less reliable at night? How does the brain represent knowledge of sensory uncertainty? How do we decide to reduce speed? The overall aim of this proposal is to investigate the neural basis of perceptual decision-making under uncertainty. I will concentrate on three major research questions. First, I aim to establish the degree to which sensory uncertainty is represented in human visual cortex. Second, I will examine whether observers are aware of this uncertainty when making decisions. Third, I will investigate the sources of noise that cause the uncertainty in our perceptual decisions. I will address these questions using functional magnetic resonance imaging (fMRI), in combination with a novel analytical method to analyzing fMRI data that I recently developed. This novel approach allows me to characterize, on a trial-by-trial basis, the uncertainty in cortical stimulus representations, and to address unresolved issues regarding the neural mechanisms of human perceptual decision-making. The results from this project will provide important new insights into the neural basis of perceptual decisions, with profound implications for theories of cortical visual function. Given that mechanisms of visual decision-making likely resemble the mechanisms underlying oth