RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biocrystallography (X) on a highly integrated technology platform for European structural genomics' (BIOXHIT) targeting Sixth Framework.

assistant: **Abstract**

The ability of post-genomic research in biology and medicine to deliver substantial improvements in human health depends critically on the rate of progress towards the understanding of complex biological processes at the molecular level, which in turn depends on our capability of rapidly determining the 3D structures of all molecules involved in atomic detail. The BIOXHIT project will develop, assemble and provide an integrated platform for high-throughput structure determination using X-ray crystallography with synchrotron radiation, which will boost such capabilities throughout Europe.X-ray crystallography is the natural choice by virtue of its accuracy, speed, and potential for further speed gains, while synchrotron radiation is indispensable because of its intensity and tuneability. BIOXHIT will coordinate scientists at all European synchrotrons and leading software developers in both academic and industrial groups in a timely and unprecedented joint effort, under an efficient management structure. It will achieve increasing levels of automation and will implement smart" data collection protocols capable of delivering expert-quality results to non-expert users. Strong emphasis will be placed on integrating the work of hitherto separate teams by early planning for standardisation and transferability, thus maximising cost-effectiveness and fostering a culture of Europe-wide concertation and exchange.A proactive training effort will first take place at synchrotron facilities, then spread to satellite centres for further dissemination. The Project will culminate with the provision of remote access to the BIOXHIT high-throughput facilities from the users' own laboratories or companies. These capabilities will be of lasting benefit to European research, underpinning all f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fire-hose Excellent Manufacturing by means of an Innovative Rubber Compounding-Extrusion-Vulcanization process' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Lay flat rubber fire hoses are a specialized product based on technology knowledge. They differentiate from lower cost alternatives in their durability, performance and their maintenance-free lifetime. Competition from low labor cost countries, presently based on lower cost alternatives, has already covered most of the building fire-fighting equipment market. European manufacturers’ technology allow them manufacture higher quality hoses so far, and this gives them the world leadership in production and exports. However, there is an important manufacturing weakness that endangers this leadership. The project will try to overcome the problems on the manufacturing of lay flat fire/industrial rubber hoses. In the manufacturing process, a NBR/PVC rubber compound is extruded through a textile jacket, and the covered (in and out) hose is vulcanized in a discontinuous process with water steam injected into the rubber hose. In the vulcanization step, blisters frequently appear on the surface of the rubber hose, leading to a very important rate of rejection. Impurities on the rubber compound, due to insufficient dispersion of the components or coming with the raw materials, could introduce surface defects on the rubber inner cover leading to the defects on the outer surface. The project will try to study, by using Case Based Reasoning (CBR), the effect of the raw materials and mixing parameters on the rejection rate to identify the cause of the problem, and new formulations will be designed. Some changes on the current discontinuous manufacturing process will also be implemented to lower the rejection rate. Current discontinuous process limits the maximum length of the hoses, and continuous vulcanization systems for this product will be designed and tested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Behavioural roles for synaptic integration' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Neurons in the brain integrate information from thousands of synaptic inputs into a single axonal output. Yet, we understand little of how synaptic integration influences cognitive processes, including learning and memory.Recently, I found that deletion from forebrain neurons of HCN1 channels, which are important for synaptic integration, enhances spatial memory, suggesting that HCN1 channels may constrain memory processes. This raises a fundamental question: Is the primary function of HCN channels to constrain memory, or does expression of HCN1 channels confer some behavioural advantage at the expense of memory?The experiments that I now propose to address this question use behavioural pradigms based on spontaneous novelty recognition in an open arena and on rewarded identification of a goal location in a radial maze. Initial experiments will use mice with forebrain-restricted deletion of HCN1 channels. Later experiments will focus on the paradigm that reveals the most profound phenotype and will investigate more localized manipulations of forebrain areas, using viruses to knock-down or turn off expression of HCN1 channels in restricted populations of neurons.By enabling dissociation of the influence of HCN1 channels on different components of information processing underlying memory storage and recall, the proposed project will develop new principles for understanding the roles of HCN1 channels and synaptic integration in episodic memory. This may suggest new experimental strategies to investigate common psychiatric and neurological disorders that are increasingly recognized to involve disruptions to the integration of information, for example schizophrenia, autism and epilepsy.The proposed project will contribute to European re-integration by enabling me on my return
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel Bone Morphogenetic Protein-6 Biocompatible Carrier Device for Bone Regeneration' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Goals: We will carry out a regenerative medicine clinical trial of the therapeutic system OSTEOGROW for regenerating bone through harnessing a novel bone regenerative product to accelerate and enhance bone repair.The osteogenic regenerative product is composed of an autologous carrier and a biologically active recombinant human protein offering a therapeutic solution in bone regeneration superior to currently available options.The autologous carrier is a whole blood coagulum derived (WBCD) from the peripheral blood of a patient, which will act as an endogenous biocompatible material causing significantly less inflammatory reactions than currently used bone devices.The bone inducing molecule is the recombinant human bone morphogenetic protein 6 (rhBMP6) which binds to WBCD and is more potent than other BMPs in stimulating bone formation in preclinical animal models. The consortium members will scale-up the production of rhBMP6 from an already developed working cell bank to enter clinical trials on bone regeneration.The bone diseases we will treat locally with OSTEOGROW are acute radius fractures and healing of distraction gap in high tibial osteotomy (HTO). These conditions are widespread and highly debilitating diseases for which such therapy holds great promise.Workflow: Preliminary pre-clinical data are already available, and clinical grade (GMP) rhBMP6 will be available before the beginning of the project to perform toxicology studies and to determine the final formulation of OSTEOGROW. Clinical trials will start within 18 months from the start of the project funding.Business strategy: SMEs Genera Research, Vitrology Limited and Meditox will test and validate the rhBMP6 production in their facilities. Consortium members from Medical University of Vienna, Sarajevo Uni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '19th European Crystallographic Meeting and Satellites' under Fifth Framework.

assistant: **Concept**

This meeting and its satellites bring together crystallographers working in most areas of science (physics, chemistry, biology, mineralogy, applied mathematics). In that way, the crystallographic meeting is interdisciplinary. Satellites are organised before and after the meeting to teach more specific topics (frontiers in macromolecular crystallography, electron density analysis, surface crystallography, texture analysis). All events focuses on methods and important applications.We are very concerned with training young colleagues who had not the chance to participate in the last 20-30 years in the development of most important crystallographic tools. Therefore, ECM19 + S has to teach the young generations of crystallographers. This has to be done in the 2000-2004 period because soon, all crystallographers who have developed the theory and the tools will retire in the next five years. In conclusion, the main objective of ECM 19 is to keep an excellent crystallographic community at the European level in order to continue the excellent research done.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00202-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Urban Gamification for City Reappropriations' under Horizon 2020.

assistant: **Concept**

In a grey, but not yet cold, autumn day, people walk through the city centre minding their own business, looking at the pavement and ignoring the other passers-by. Then something happens: they stop abruptly, they appear perplexed, for a moment and then, slowly, their eyes are filled with awe: someone is playing some games over there, in the city streets! The citizens' reaction to moments of urban playfulness is often the same: a simple, almost childish, joy at seeing the anonymity of modern cities being invaded by coloured, fun and light-hearted activities.Nowadays, the idea that cities should not just be smart, but also playable is gaining more and more recognition. Pro-social activities such as those organised by the Watershed of Bristol try to channel the power of city play (already exploited by bottom-up, spontaneous activities such as parkour, flash-mobs and zombie walks) and use it to promote more inclusive communities and a sense of city-ownership.This proposal aims at studying urban play in the wider frame of gamification, in order to deepen our understanding on how we can use play to affect the urban spaces and on what effects this might have on the citizens and their practices. The project draws from the knowledge and methodologies of gamification, critical design and pervasive play and aims at building an innovative and usable methodology. The latter will be tested through the analysis of case studies and through empirical testing, thus allowing the ER to build a framework for the study and design actions of urban gamification.ReClaim will be carried out within the Gamification Group of Tampere University of Technology (the most published and cited group on the topic) and during a secondment at the Watershed of Bristol (home of Playable Cities). This, togethe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Refiguring Conservation in/for 'the Anthropocene': The Global Lives of the Orangutan', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In recent years, conservationists have engaged in heated debates about whether and how conservation should respond to the challenges posed by ‘the Anthropocene’—a term increasingly used to encapsulate the overwhelming, transformative impact of human activity on the Earth system. How are these debates—and the wider ‘Anthropocenic’ awareness they embody—reshaping conservation philosophy, strategy and practice? How are they manifested in and across diverse contexts? How, conversely, are global conservation developments and ‘Anthropocenic’ phenomena apprehended and reshaped on the ground? This project explores such urgent questions through an unprecedented study of the global nexus of orangutan conservation at a unique historical juncture marked by flux and uncertainty. Combining in-depth ethnography and multiply-scaled cross-cultural comparison, it approaches orangutan conservation as a sprawling, uneven terrain across which the rapidly-evolving relationship between conservation and ‘the Anthropocene’ is being played out. Its objectives are 1) to examine if and how contemporary conservation is being ‘scaled up’ and re(con)figured in and for ‘the Anthropocene’; and 2) to cut ‘the Anthropocene’ down to size by exploring how it is experienced, conceptualized, contested or indeed refused across multiple conservation settings. Comprising four interlinked studies to be carried out simultaneously at the main nodes of orangutan conservation, this project seeks to pioneer a new synchronic, multi-sited approach to the analysis of global conservation and lay the groundwork for an empirically-driven, theoretically ambitious new field of scholarship on conservation in/for ‘the Anthropocene’—one that will revitalize social scientific understandings of conservation while adding much-need
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transnational Network of cooperation for WIDESPREAD NCPs' (2014-2020).

assistant: **Innovation**

The objective of the NCP_WIDE.NET is to create a transnational network of National Contact Points (NCPs) for Spreading Excellence and Widening Participation under Horizon 2020 in order to facilitate trans-national co-operation between NCPs, with a view to identifying and sharing good practices and raising the general standards of support to applicants, taking into account the diversity of actors, including newcomers, that make up the constituency of WIDESPREAD part. Project is targeted towards the Widespread NCP Forum - officially nominated WIDESPREAD NCPs in EU Member States and Associated Countries - including experienced and less experienced NCPs. Expected impacts of the proposal aiming at ensuring quality standards of services, lowering entry barriers and increased applications to Horizon 2020 will be reached through a portfolio of dedicated meassures. The overall logic of the proposal is based on the improving  and leveling of the NCPs capacities to deliver services of high quality standards, enhancing transnational collaboration between  applicants, delivering complex information on WIDESPREAD activities and promoting the Network itself. The implementation of the proposal includes following tailored actions:  internal trainings and mentoring based on benchmarking, support to WIDESPREAD expertise through development of guides and reports, transnational collaborative events for stakeholders such s brokerage events and joint workshops, actions dedicated to newcomers, networking activates, dissemination actions, complex source of information (Project Portal one-stop-shop) and promotion activities. Proposal addresses the work programme in terms of supporting and leveling NCPs capacity in delivering services of high quality standards. The project will contribute to more
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Virological characterisation of primary hiv infection in the concerted action on seroconversion to aids and death in europe (CASCADE VIROLOGY)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

This project will combine data from European cohorts of persons with known dates of HIV seroconversion (seroconverters) to assess to what extent transmission with drug resistant HIV impacts on clinical outcome. The individual cohorts have been specifically set up as HIV natural history cohorts and study subjects are followed-up life-long from their initial contact with HIV. Although transmitted drug resistance has been documented, but may be under-estimated if data are not derived from seroconverters, its clinical importance has not been established. In studies of persons with known dates of seroconversion, the numbers included are often small and it is very difficult to draw conclusions, on whether a blunted immunology and virology response to therapy is more likely in someone newly infected with drug resistant virus than someone who is not.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mycobacterium tuberculosis W-Beijing genetic diversity and differential virulence and host immune responses' (TB-VIR), addressing dissemination and exploitation.

assistant: **Impact**

Improvements in TB control require the development of new tools for rapid and accurate diagnosis and intervention. This development is likely to benefit from more detailed knowledge of microbe-host relationships during infection. Following M. tuberculosis infection, only 5-10% of immunocompetent individuals develop TB. It is increasingly thought that the virulence of the infecting strain, together with host genetic factors, contribute to such differences between infected individuals. The M. tuberculosis W-Beijing lineage is one of the most successful mycobacterial families, in terms of morbidity and mortality. This lineage has been detected almost worldwide. The predominance of the W-Beijing lineage probably results from genetic advantages, including unidentified virulence factors and the induction/modification of specific host responses not yet thoroughly investigated. This project aims to unravel the links between differential host responses to M. tuberculosis infection and mycobacterial genetic diversity and virulence at the global genomic and post-genomic levels within the W-Beijing family, and between the W-Beijing family and other M. tuberculosis families, in order to improve our understanding of the epidemiological success of this particular lineage. Overall, this work will provide the scientific and clinical community with pioneering research and novel information increasing our understanding of the impact of M. tuberculosis strain diversity on virulence, immune response and pathology. This project will complement and expand the efforts of several internationally recognized laboratories to unveil new genotype-phenotype associations by integrating complex phenotypic data and information about mycobacterial genetic diversity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanoreactors for controlled radical polymerizations based on the thermosome from Thermoplasma acidophilum: Templating synthesis of polymer nanoparticles and in-situ regeneration of the template' (THERMOSOMENANOREACT), addressing dissemination and exploitation.

assistant: **Impact**

Polymer nanoparticles have found applications in high performance materials and in medical applications. An attractive route to these particles is the use of templates. However, templating methods have the disadvantage that one templating entity is needed for every object that is formed. The ideal template for polymerizations would therefore be a nanoreactor that regenerates itself once the nanoparticle is formed. Nature provides us with a protein assembly that, when further modified, may fulfill this requirement. The thermosome from Thermoplasma acidophilum is a protein complex which encloses two central cavities with a void volume of 130 nm3. Each cavity is accessible via several small pores and one large pore. The large pore is gated by a build-in lid, whose opening and closing can be controlled by ATP. I propose to use the thermosome as a nanoreactor for Atom Transfer Radical Polymerization (ATRP). To this end, an appropriate catalyst will be covalently linked into the cavity of the protein complex. In the thermosome’s closed conformation, monomers, crosslinkers and initiators can enter the cavity through the small pores, and a polymer particle will form inside of the protein. The cavity of the thermosome acts as template in order to generate nanoparticles of defined size and shape. By opening the lid, the particles will then be released into the surrounding media and the nanoreactor regenerated for further reaction cycles. The objective is to run the process in a continuous way, so that the production of the nanoparticles becomes catalytic. To this end, the formation of the particles will be synchronized with the opening-and-closing cycle of the thermosome. Furthermore, the effect of the confined reaction space provided by the cavity will be exploited to achieve an