RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel smart glyco-nanomaterials as targeted therapeutics.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cell surface carbohydrates play key roles in cell recognition mechanisms. Protein-carbohydrate interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. O-glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cellular stimuli through the action of the cycling enzymes. Expression of specific O-glycans is linked to changes in gene expression in, for example, inflammatory bowel disease, cystic fibrosis and several types of cancer. Understanding these glycosylation patterns at molecular and functional levels will allow mechanisms associated with bacterial-host interactions, bowel disease and other cancers to be defined, which will facilitate the development of new effective therapeutics and diagnostic tools for these conditions. The proposal centers on the chemo-enzymatic synthesis of novel multivalent mucin-type O-glycan probes for the screening of O-glycosylation-linked interactions in health and in disease and the development of smart glyco-nanoparticles as drug delivery systems. This is a multidisciplinary project involving synthetic organic and inorganic chemistry and glycobiology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'JTI-Clean Sky 1-Smart Fixed Wing Aircraft-Integrated Technology Demonstrator', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

SFWA - Smart Fixed Wing Aircraft: SFWA is developing two major large transport aircraft technologies the first mainly related to the drag reduction by using laminar flow and known as 'smart wing', and the second related to the integration of advanced (ultra-) high bypass propulsion concepts such as Open Rotor. The objective is to achieve maturity levels in both technologies to a status close to a potential application through major, dedicated large scale ground and flight demonstrations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Strengthening resilience and mental wellbeing through the Support4Resilience toolbox for leaders in elderly care' (Support4Resilience).

assistant: **Innovation**

European elderly care experiences labor shortages, lack of qualified workers and a mismatch between capacity and demands, causing stress, burnout, and reduced mental wellbeing among healthcare workers and informal caregivers. Leaders are crucial in promoting supportive working conditions but lack research-based measures to act upon these challenges.Support4Resilience (S4R) will develop, implement, and evaluate a research-based Toolbox to support healthcare leaders in improving healthcare workers’ and informal caregivers’ resilience and mental wellbeing in elderly care. S4R will identify resilience and mental wellbeing factors among healthcare workers and informal caregivers; explore their perspectives and needs; develop new theory on the relationship between individual and organizational resilience, and mental wellbeing; and develop recommendations and cost-effective interventions. The Toolbox with tailormade resources for policy and practical use will be available through an open access S4R Resource Bank.The S4R Toolbox includes three main tools: 1) Mapping and identification, 2) Reflection and education, and 3) Reorganization. Measures are initiated at the organizational level and effects on mental wellbeing and resilience transpire at the frontline of elderly care. The Toolbox covers different situational contexts, types of healthcare providers and health system levels. Elderly care settings in six European countries will implement and evaluate the Toolbox through a process evaluation, effectiveness evaluation, and cost-effectiveness evaluation. S4R provides policymakers, decisions-makers and leaders with solutions for taking action to solve specific risks for healthcare workers’ and informal caregivers’ resilience and mental wellbeing. Thus, pertinent to the work pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CONTROL OF AROMA COMPOUNDS IN STRAWBERRY' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Strawberry (Fragaria × ananassa) fruit flavor and aroma are among the most appreciated quality traits by consumers; as such, the improvement of strawberry flavor is receiving increasing importance in breeding programs. However, breeding for better aroma, particularly in polyploid crops, presents many challenges and requires a previous knowledge of the genetic determinants controlling its variation.More than 300 volatile compounds have been detected in strawberry, although less than 20 contribute significantly to strawberry flavor. In a previous study we have identified QTLs controlling the content of 48 different volatiles, including the majority of those described as key for strawberry aroma. In this proposal we want to identify the molecular mechanism underlying some of the major QTLs. To achieve our goals we will use complementary approaches and leading technologies, such as saturated genetics maps of strawberry based in SSR and SNP markers, global transcript quantification by RNA-seq, metabolomic, biochemistry and molecular biology tools, including the development of transgenic strawberry plants for validation of identified loci. The Plant Innovation program at the UF offers an integrated and multi-disciplinary approach to flavor research and will facilitate the consecution of our objectives. This proposal will use an economically important crop, strawberry, to identify genes controlling important volatiles and validate whether markers linked to them are useful in other strawberry backgrounds. Because several volatile compounds are common to other important crops such as peach or ornamental species such as rose, the obtained results will facilitate advances in other species.We envisage that the identified genes or markers closely linked to them will increase the eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Oxytocin and Dopamine Interplay in Humans – on the Biology of Social Cognition' (BIOSOCIOCOG), addressing dissemination and exploitation.

assistant: **Impact**

This project asks ‘Do oxytocin and dopamine systems interact in the human brain?’. It will encompass an innovative, inter- disciplinary method combining established techniques in neuropharmacology, neuroimaging and genetics. It will use a mentalizing (social dilemma) task where it is hypothesized that the trust-eliciting reward value of mutual cooperation is coded by both dopaminergic and oxytocinergic actions in the striatum. Support for this comes from dopamine´s well-characterized role in reward learning and oxytocin’s recently found impact on affiliate and cooperative behavior and its neurocorrelates. As a way of assessing these systems, I will combine, for the first time, oxytocin and dopamine manipulations; as well as integrate information from natural genetic variability to further support my predictions. The underlying assumption is that acute changes in their striatal levels as well as chronic predispositions affecting their systems can influence striatal activation during social reward processing. (Chronic predispositions arising from environmental historical events and personality will also be taken into account.)There is robust evidence that interplay between the dopamine and the oxytocine systems is crucial for social cognition from animal studies, however this has not yet been investigated in humans. The question is paramount and timely as mental illness enigmas involving trust/paranoia, social avolition and anxiety or drug addiction are still unresolved and new oxytocinergic therapies are now being clinically trialed for autism and schizophrenia (and partially to complement dopaminergic ones, as in the case of the latter). The ultimate goal herein is to inform the rational design of treatments for these conditions by better understanding the biological un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantum Measurements and Ground State Cooling of Mechanical Oscillators', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cavity optomechanics has over the past years emerged as a new research field in which basic concepts of quantum measurement theory such as quantum limited displacement sensing or backaction evading measurements as well as highly sensitive force measurements may be realized by virtue of radiation pressure optomechanical coupling to nano- and micro-mechanical oscillators. The objective of this research area is to achieve quantum limited detection of mechanical motion and ground state cooling of a mechanical oscillator. Analogous to the success of quantum limited photon detectors in the field of quantum optics, it is likely that quantum limited motion transducers will continue to lead to new advances in both fundamental science and technology. The significance of the research program lies in experimentally approaching the fundamental quantum limits of motion transduction and demonstrating quantum phenomena of a mechanical oscillator; the most tangible harmonic oscillator. This research will directly build on the recognized contributions of the participating Swiss research group, which is the Laboratoy of Photonics and Quantum Measurements of Dr. Tobias J. Kippenberg at the EPFL. The research group has over the past 4 years made many seminal and widely recognized contributions to the field of cavity optomechanics. The applicant is a French scientists who obtained his PhD at ENS in Paris in the labatory of the world renowned Quantum Physics pioneer Serge Haroche. His work has been pioneering and has been published in leading journals (including two publications in Nature). The proposed research activities are at the forefront of the rapidly developing field of cavity optomechanics - which has sparked widespread contemporary interest in Physics - , and will place the applican
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'LASER DENTAL MULTIWAVING SYSTEM WITH WAVELENGTH' (LASERDENT), addressing dissemination and exploitation.

assistant: **Impact**

LASERDENT was based on the validation of the Multiwave Dental Laser System with wavelength mixing through application partners (universities, clinics, application centres, dental offices) in Germany and the Netehrlands. The project aimed to support the transistion of the prototype model to a generally applicable instrument for the international markets. The technology for this has been developed over the last 4 years with a prototype installation in Austria. The core innovation is the possibility to apply and mix 3 different laser systems and wavelengths simultaneously within one tool - Er-Laser : Ablation, Ho-Laser : Cutting, Nd-Laser : Coagulation and disinfection. This system enables for the first time to cover the whole spectrum of established laser procedures in dentistry and oral surgery. The possibility of simultaneously mixing different wavelengths opens completely new therapeutic applications for the benefit of the patient.The project consortium consisted of European endusers and application partners for each segment of the validation process (Ergonomics, Hard tissue treatment, Endodontics, Periodontology, Prevention). Local intermediaries performed the training, support and co-ordination of the endusers and performed all activities for the dissemination process.The core benefits of the project were seen to be:- it supports the competitiveness of the European high tech companies involved in the LASERDENT project and its partner.- dental and medical science can benefit on a European level with new oral technologies- dental operators can apply a new technology to the benefit of the patients due to more effective and painless working methods- the European medical support system will generally benefit from the introduction of the technologies.After the validation p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A novel characterization- and reliability-oriented simulation software for dielectric-based nano-electronic devices', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

MDLab (Modeling Dielectric Laboratory) has developed a novel micro- and nano-electronic devices simulation software focused on the physical phenomena occurring in the dielectric layers i.e. charge and ion transport, charge trapping, and structural degradation. The MDLab software has several distinctive features (i.e., automatic interpretation and calibration, full reliability simulation, focus on dielectric-based devices with a multi-scale atomic approach, flexible graphical interface resembling a measurement instrument) compared to the TCAD software available on the market, which represents a great opportunity to successfully enter the market by responding to needs currently not covered by competitive commercial TCAD tools. Thanks to a novel user interface concept designed to be intuitive, a broad adoption of the software is expected from non-simulation-experts, who can benefit from the Graphical User Interface (GUI) simplicity, allowing connecting the electrical curves to the atomic/physical properties of the dielectric materials in an intuitive simulation environment.  MDLab aims at becoming an European and worldwide company developing simulation software for electronic devices, changing the way simulation tools are used in the semiconductor industry, thanks to the friendly and flexible interface connecting electronic device performance/reliability to atomic device properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative RUNning gear soluTiOns for new dependable, sustainable, intelligent and comfortable RAIL vehicles' to be submitted under Horizon 2020.

assistant: **Abstract**

The RUN2RAIL project will explore an ensemble of technical developments for future running gear, looking into ways to design trains that are more reliable, lighter, less damaging to the track, more comfortable and less noisy. These innovations will be proposed in the form of case studies supported by the methods and tools elaborated in the project.The project develops across four thematic Work Streams: Innovative sensors & condition monitoring, Optimised materials & manufacturing technologies, Active suspensions & mechatronics, Noise & Vibration. In these four areas, the project will provide a coordinated set of technical key contributions including (but not limited to):- smart sensors and smart running gear components with self-diagnosing capability;- use of novel materials and manufacturing methods in combination with intelligent / active suspensions to enable non- conventional running gear concepts;- identification of efficient fabrication processes for the running gear (3D metal printing, automated tape layering of composite  materials);- assessment of existing off-the-shelf technology for active control coming from other sectors; development of a novel and comprehensive methodology for predicting the transmission of noise and vibration from the running gear to the carbody.Within the four workstreams, the project will also perform a preliminary evaluation of the related regulatory and standardisation issues, together with a careful assessment of the impacts of the new solutions proposed. The research conducted will be multidisciplinary, i.e. based on the integration of different branches of engineering such as mechanical, materials, electronic and electrical engineering, and will establish models and formal methods to explore a full set of technological developments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'MICROMACHINED OPTOMECHANICAL DEVICES: looking at cells, tissues, and organs ... with a gentle touch'.

assistant: **Innovation**

Every time we grab an object to look at its geometrical details or to feel if it is hard or soft, we are ineluctably confronted with the limits of our senses. Behind its appearances, the object may still hide information that, encrypted in its microscopic features, remains undetected to our macroscopic assessment. In life sciences, those limits are more than just frustrating: they are an obstacle to study and detect life threatening conditions. Many different instruments may overcome those limits, but the vast majority of them rely either on “sight” (optics) or “touch” (mechanics) separately. On the contrary, I believe that it is from the combination of those two “senses” that we have more chances to tackle the future challenges of cell biology, tissue engineering, and medical diagnosis.Inspired by this tantalizing perspective, and supported by a technology that I have brought from blackboard to market, I have now designed a scientific program to breach into the microscopic scale via an unbeaten path. The program develops along three projects addressing the three most relevant scales in life sciences: cells, tissues, and organs. In the first project, I will design and test a new optomechanical probe to investigate how a prolonged mechanical load on a brain cell of a living animal may trigger alterations in its Central Nervous System. With the second project, I will develop an optomechanical tactile instrument that can assess how subsurface tissues deform in response to a mechanical stroke – a study that may change the way physicians look at tissue classification. For the third project, I will deliver an acousto-optical gas trace sensors so compact that can penetrate inside the lungs of an adult patient, where it could be used for early detection of pulmonary life threat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel technology to boost the European Bioeconomy: reducing the production costs of PHA biopolymer and expanding its applications as 100% compostable food packaging bioplastic' (EUROPHA) targeting Seventh Framework.

assistant: **Abstract**

Bioplastics like PHA are long-term sustainable alternatives because they can show equal performance to conventional petrochemical plastics, originate from renewable non-food resources and are 100% bio-degradable.  Although PHA shows better performance than alternative bioplastics (PLA and starch), the market uptake of PHA biosplastics shows the following obstacles: 1) PHA is expensive (>4.5 €/kg), much higher than starch plastics and other bio-based polyesters. This is caused by three facts in the production process: High raw material costs; expensive PHA extraction to ensure high quality; small production volumes. The second obstacle is the 2) Small market share of European PHA (dominated by China and US) that limits the potential of a European Bioeconomy. EuroPHA will solve the need to establish a competitive PHA production capacity in Europe by: a) Reduction of PHA production costs: using low-value feedstock (agro-food waste/surplus streams) as starting material in  three-phase biological synthesis of PHA by mixed microbial culture; b) Environmentally friendly & cost-effective PHA extraction step; c) Novel formulations of PHA for 100% complete and short-time biodegradability packaging bioplastics by current industrial technology: monolayer film and extrusion foam for food packaging. EuroPHA will provide these economic benefits for Europe by our project members: 40% reduction of final price (≈2.6€/kg), this will enable the increase of European PHA global market share from current 0.1% to 15% in five years post project (45 ktpa worth 135€ million) for food packaging applications. Price-competitiveness vs. starch-based (today 3.75 €/k) and PLA (2.5€/kg) making possible to penetrate a 20% in the starch-plastic market (22 kpta with revenues of 90€ million) and 15% in the