RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a point-of-care microfluidic device for Therapeutic Drug Monitoring in cancer treatment (POC-TDM)' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cancer claims almost 10 million lives annually, making it one of the major causes of death around the world. Despite the development of novel drugs and treatment options, the 5-years survival of the most common cancers are still strikingly low. Chemotherapy (CT) is a widely used option to treat malignancies, however CT protocols are established on a “one size fits all” basis and ignore inter-patient differences in drug pharmacokinetics which influence the blood levels of anticancer drugs, therefore leading to improper dosing in 50% of patients. Missing target blood concentration will lead to drug resistance and/or unwanted side effects. Therapeutic Drug Monitoring (TDM) could be the key to improve and personalize CT, however the lack of an affordable point-of-care (POC) method is preventing its introduction to oncology. Mass spectrometry (MS) is the golden standard analytical approach to determine blood drug levels, but the instrument and specialized expertise to operate it are rarely available in the clinical environment. The high volume of blood required for MS analysis is also a challenge, because cancer patients are regularly weakened. Exploiting the strong and specific fluorescence of anthracyclines, the most used CT agents, we propose a radically new microfluidic chip-based approach to rapidly determine plasma concentrations of several widely applied anticancer drugs. Microvolume plasma separation and collection from a drop of blood (>50 ul) will be done with a specifically designed chip, then plasma anthracycline concentration will be measured using a compatible spectrophotometer. The approach will be validated using clinically relevant mouse tumour models and with samples from veterinary cancer patients. This interdisciplinary project, combining microfluidic eng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Farm level optimal Water Management: Assistant for irrigation under deficit' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The objective of FLOW-AID is to contribute to sustainability of irrigated agriculture by developing, testing in relevant conditions, and fine-tuning through feed-back, an irrigation management system that can be used at farm level in situations where there is a limited water supply and water quality. The project integrates innovative sensor technologies into a DSS for irrigation management; taking into consideration relevant factors in a number of third country partners.The specific objectives are to develop and test new and innovative, but simple and affordable, technical concepts (hardware and software) for irrigation under deficit at farms in a large variety of set-ups and constraints, particularly a maintenance free tensiometer; wireless, low-power data networks; an expert system to assist farm zoning and crop planning, in view of expected water availability (amount and quality); a short-term irrigation scheduling module that allocates available water among several plots and schedules irrigation for e ach one.The scientific results from the research will be evaluated in four test-sites, three of them located in Mediterranean Party Countries (Turkey, Lebanon and Jordan), where the large future market for deficit irrigation systems will be. The test-sites are chosen in such a way that they differ in the type of constraints, irrigation structures, crop types, local water supplies, availability of water and water sources in amount and quality, the local goals, and their complexity. The SME partners will take up research results and build prototypes, which will be installed at the test-sites. In close co-operation all partners will adapt the general concepts of water management to the local situation, by using appropriate parts of it, based upon the test-results. The SME
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modelling effects of exposure to mixtures of chemicals on a multi-species level' (BIOME).

assistant: **Concept**

Predicting effects of chemicals in real life situations is a very complex undertaking, but also very important in terms of the sustainability of our environment. The complexity lies in the enormous variation that is found in real life situations. A variety of organisms is exposed to a variety of chemicals, with a different composition in space and time. This is far from a laboratory situation, where single organisms are exposed to mostly single compounds in a homogeneous environment.As 20 different compounds already allow more than one million possible mixtures we need tools in the form of mathematical models to assess real life exposure situations. These tools must be able to extrapolate from one compound to a mixture containing that compound, from one compound to a compound that was not measured, from effects at some point in time to different points in time and from one species to another.The first steps in the development of such a model were taken during my PhD research, we showed that it is possible to predict effects on a single species, exposed to a real life mixture of metals, pesticides, PAHs, PCBs, nutrients, salts, etc. with great accuracy.The aim of the proposed research is to extend the current single-species approach to a multi-species approach. This would be an important step forward as such an approach is of great practical importance in environmental quality management, understanding and predicting effects of chemical pollution on biodiversity and in understanding and predicting environmental effects caused by accidents and spills. We will build on the existing model, further develop the model to predict effects for untested species, apply QSAR approaches to predict effects for untested compounds and make use of existing experimental data gathered by t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving and professionalizing the Health NCP service across Europe.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Health NCP Net 2.0 aims at improving and professionalizing the NCP service, thus achieving a more consistent level of NCP support services across Europe with the final goal to better support applicants and raise the average quality of proposals submitted. HNN 2.0 builds upon the experience and results of the previous Health NCP Net project with the objective of responding to the new challenges that the “Health, Demographic Change and Wellbeing” NCPs face in the new programme Horizon 2020, such as the broadened thematic scope of the Societal Challenge 1, and the enlarged mandate of the “Health” NCPs. An objective of the HNN 2.0 project is to satisfy the needs and priorities of all different types of NCPs, notably newcomers, NCPs with fewer resources, NCPs from EU-13 and NCPs in Third Countries so as to face the  challenge of the current heterogeneity of the network The enlarged mandate of “Health” NCPs and the holistic focus of H2020 imply that NCPs need to create expert knowledge and look for it outside the SC1 Network by having a holistic approach and liaising and collaborating with other support structures, projects and programmes. HNN 2.0 will therefore have a real structured coordination with the other NCP and support networks such as Ideal-IST, EEN and Fit for Health 2.0, where collaboration for joint activities like training courses, meet and exchange workshops and brokerage events is established. Main tools towards the objectives:  - support and information materials - comprehensive training programme - mentoring programme (staff exchanges, mentoring programme for EU-13, twinning with the European Commission) - Meet and Exchange workshops with NCPs from other disciplines - system of email alert for NCPs about research funding and related policies- information and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tactical Integration of Telematics Applications across Intelligent Networks' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

TITAN is a pan-European consortium of Regional Service Providers (including public administrations, local authorities and regional development agencies) and Industrial Partners (telematics Small and Medium sized Enterprises (SMEs) and national Public Network Operators) who are building on previous collaborative work to initiate a series of innovative regional and trans-national service integration activities to improve the quality of life for citizens and SMEs within rural areas through the application of telematics.Within the TITAN project, these organisations will co-ordinate and network their activities to improve ease of access to and use of their services within rural areas by developing standard means for the presentation and delivery of information and accompanying interactive services. TITAN will integrate current and previous TAP applications developed by the Consortium partners with the specific objectives of verifying and demonstrating an innovative TITAN Integrated Service Application in each of the consortium's four regions through:- a methodological focus on organisational integration in parallel with technical integration- specification and implementation of open-systems platforms for Integrated Service delivery in each Digital Site- integration of advanced tools for search and retrieval and application of map-based paradigms to provide versatile end-user service- implementation of Regional Service Access Points (kiosks, home-PC, mobile, Service Centres)- development and dissemination of a TITAN Regional Service Integration Architecture, incorporating a Core Service Model and Common Service Catalogue, through the pan-European TITAN User Group- the establishment of Regional Service Integration and Validation Groups [provider and end-user domains] as key or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metrology of Carbohydrates for Enabling European Bioindustries', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

CarboMet will foster and drive collaboration, cross-fertilisation and communication among stakeholders to facilitate a uniform approach to the metrology and/or measurement of carbohydrates for exploitation in biopharmaceuticals, diagnosis of disease and precision medicine, food and personal care and sustainable material BioIndustries. This will be achieved through a consolidated approach towards the modification of key emerging technologies or identification of radically new technologies currently unforeseen by technology roadmaps.Carbohydrates and glycoconjugates are especially challenging to analyse due to their high stereochemical diversity which means it is difficult to distinguish between them and fully characterise using standard techniques and methods. Current methodologies to fully solve 3-D structures include NMR and X-Ray Crystallography which are low-throughput, require large samples and have poor sensitivity. Emerging technologies are beginning to address these issues such as Ion Mobility Mass Spectrometry (IM-MS) and the combination of 3 gas phase techniques: IR spectroscopy with IM-MS in-vitro enabling high-throughput with higher sensitivity, small samples, and analysis from mixtures to provide structural detail on each component. These technologies are underpinned by advanced supporting technologies such as automated carbohydrate synthesis, bioinformatics tools and databases, and new suites of enzymes for glycan synthesis and modification. CarboMet will use a range of communication and dissemination tools (meetings, workshops, website, surveys, briefing papers) to engage key stakeholders, to establish the current emerging technologies, limitations, and barriers to implementation. Priority areas, future challenges and a wish list of capabilities will then
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Eradication: the science and politics of a world without AIDS' under Seventh Framework.

assistant: **Concept**

New biomedical technologies and public health strategies are being tested world-wide with the goal of eradicating the HIV epidemic. Achieving a world without AIDS has become the flagship of the vast global health apparatus, rallying governments, international organisations, philanthropic and pharmaceutical capital, research networks and activists. Mass screening and treatment, preventive drugs and gels, and molecular maps of sexual networks have shifted the biomedical paradigm from one of control to one of eradication. The biopolitical armamentarium of the push to eradicate may inadvertently enable unexpected biological, cultural, social and political transformations. Mass treatment and preventive drugs require very high levels of compliance to achieve the desired public health effects, foreshadowing the coercive potential of eradication efforts. Intensified mapping of “most at-risk populations” marks a shift from the existing emphasis on rights and empowerment to one of surveillance and discipline. As these approaches remain unproven, eradication constitutes a global public health experiment of unprecedented proportions, whose outcomes will shape global health efforts for decades to come. Eradication efforts to rid the world of HIV are attempts to order nature as revealed through a global epidemic, putting them squarely at the centre of anthropological concern. The two overarching questions are: what will HIV eradication efforts achieve? What are the reasons for the outcome, be it partial success or partial failure? To answer these questions, a multi-sited ethnography will be conducted in Africa, Europe and North America of the science and politics of HIV eradication. It will focus on the testing, preparation, and implementation of the three key technologies of HIV era
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Performing Spaces: Architecture, Spatiality, and Politics in European Ceremonial Cultures, circa 1550-1700' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

This project explores the uses of architecture, architectural imagery and symbolic space in the festive cultures of early modern Europe. Historians and social scientists have often connected changing notions of elite public and private spaces to discourses of centralisation and modernisation in differing European ancien regimes. Combining textual and historical evidence, visual sources, evidence from material culture, and sociological and critical theory, this study will explore the competing definitions of court spaces either as a fixed static entity or as a fluid and moveable space, and how these definitions are conceptualised, embodied, enacted, and represented in a range of festive cultural practices. The study contrasts representations of elite spaces and, in particular, architecture, architectural forms and discourses, in differing arenas such as court, the city, and the country, and in different regions and countries. Part of the evidence will be drawn from British examples, evaluating Jacobean and Caroline progresses alongside the more familiar court masques of the two reigns, and contrasting these with diasporic festive forms in Britain’s subaltern societies (Ireland, Isle of Man, Scotland, Wales). British exemplars will be contrasted with European festive cultures, especially those from the Low Countries and the German states. The study aims to develop a comparative and pan-European approach to interpreting festive cultures. One key aspect will be to explore the differing European approaches to centralisation and nation-state formation as one of the defining markers of modernity, an issue that retains its political resonance in modern Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Repurposing of carbamazepine for treatment of skeletal dysplasia'.

assistant: **Innovation**

Genetic skeletal diseases (GSDs) are an extremely diverse and complex group of rare genetic diseases that affect the development the skeleton. There are more than 450 unique and well-characterised phenotypes that range in severity from relatively mild to severe and lethal forms. Although individually rare, as a group of related genetic skeletal diseases, GSDs have an overall prevalence of at least 1 per 4,000 children, which extrapolates to a minimum of 225,000 people in the 27 member states and candidate countries of the EU. This burden in pain and disability leads to poor quality of life and high healthcare costs.Metaphyseal chondrodysplasia, type Schmid (MCDS) results from mutations in collagen X and affects <1/100,000 of the population. Mutant collagen X molecules miss-fold during synthesis and are retained within the endoplasmic reticulum (ER) of hypertrophic chondrocytes, thereby causing ER stress. Our extensive pre-clinical studies have shown that carbamazepine (CBZ) can alleviate ER stress caused by the expression of mutant collagen X and restore bone growth in a validated mouse model of MCDS. CBZ is an FDA approved drug used for the treatment of epilepsyand bipolar disorder and received orphan drug designation by the European Commission for the treatment of MCDS in September 2016.MCDS-Therapy was originally proposed as a 5-year collaborative project comprising world-renown clinical centres and SMEs to advance the repurposing of CBZ for MCDS (up to the Marketing Authorization Application dossier) through a multicentre and multinational (EU & AUS) clinical trial (Phase1, Phase2/3). MCDS-Therapy also encompasses biomarkerdevelopment and health economics assessment studies to deliver, evidence to inform potential further studies of an innovative and affordable (CBZ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Impact of Neutrino-Nucleus Interactions on DUNE's CP-Violation Measurement' under Horizon 2020.

assistant: **Concept**

The question of why matter is able to exist in abundance in our Universe is one of the most exciting open questions in physics today. One possible source of a matter-antimatter asymmetry is an as yet undiscovered difference between neutrino and antineutrino oscillations (CP-violation).  DUNE is a next generation long-baseline neutrino oscillation experiment that aims to discover CP-violation in neutrino oscillations for the first time.  An intense accelerator (anti)neutrino beam from Fermilab will be directed at far detectors 1300 km away.  In order to observe this difference, the experiment must contend with the fact that our planet and detectors are made of matter and not antimatter. Any differences between the way neutrinos and antineutrinos interact with atomic matter must therefore be well understood in order to disentangle these differences from CP-violation in the neutrino oscillations themselves.In this action I will work to reduce the systematic errors on DUNE's CP-violation measurement caused by uncertainties in our understanding of neutrino-nucleus interactions.  The  work will be centered around DUNE's currently operating prototype detectors.  This work is essential to conduct now since DUNE will use argon as its neutrino interaction target nucleus, resulting in more complex nuclear effects than experienced by the current generation of long-baseline neutrino oscillation experiments, which use lighter nuclei.  In particular I will simulate the effects of different nuclear models on the interaction probabilities for neutrinos and antineutrinos and apply new analysis techniques to better distinguish between different nuclear models, ultimately improving DUNE's sensitivity to CP-violation in neutrino oscillations.


**Keywords:** CP-violation, liquid argon TPCs,