RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating Caspase 4 and Toll-like Receptor 4 Modulation by Endogenous Cardiolipin in Health and Barth Syndrome' (CL-ImmunoDimmer).

assistant: **Concept**

Barth Syndrome (BTHS) is a disease characterised by reduced production of unsaturated mitochondrial cardiolipin (CL) and increased production of abnormal CL with saturated chains. Chronic inflammation and increased vulnerability to infection are major contributors to mortality in BTHS patients. The connection between these immune dysfunctions and CL modifications is not understood. My research has shown that unsaturated CL inhibits caspase 4 (CASP4) and Toll-like Receptor 4 (TLR4). Moderate CASP4 and TLR4 activation by bacterial triggers is essential for antibacterial defence, while uncontrolled activation results in infection lethality and inflammatory disease. My preliminary data show that abnormal CL similar to the one found in BTHS patients does not inhibit CASP4, and saturated CL activates TLR4. These findings suggest that in health, unsaturated CL acts as a dimmer to fine-tune immune reactions, while in BTHS, this dimmer is compromised, resulting in immune dysfunction. To investigate this hypothesis, this proposal ideally combines my expertise in cardiolipin and mitochondria research with the host’s expertise in gene editing and live microscopy. Using well-established methodologies, we will deplete CL from monocytes and macrophages and study how this affects CASP4 and TLR4 activation. Moreover, I will characterise BTHS immune response through the analysis of inflammatory markers in patients’ plasma, and patients’ neutrophils, monocytes and macrophages CASP4 and TLR4 response. This will provide a deeper mechanistic understanding of inflammatory processes in both health and disease, potentially identifying CL, CASP4, and TLR4 as new targets for treating BTHS. While I will enhance the team’s multidisciplinary character and provide collaboration opportunities, I will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nmr tools for the study of transient intermediates in biomolecular processes' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Objectives: The proposal aims at the development of dedicated NMR probes and the accompanying NMR tools for the structure determination of rapidity formed, short-lived intermediates that are important in biological processes. These transient intermediates can be induced in a biomolecular system by photochemical means or by a rapid change of solvent conditions. Therefore, both a rapid mixing and a laser coupled probe will be made in which all modern multidimensional NMR experiments including the use of pulsed field gradients are possible, with as little compromise on the NMR performance as possible. These NMR probes and the set of developed experimental methods will be validated for photobiology, in protein and RNA folding studies, and in CIDNP experiments.Results: Project Manager: Robert Kaptein NMR Spectroscopy, Bijvoet Center for Biomolecular Research Padualaan 8 Utrecht 3584-CH The Netherlands Tel: 31-30 2533787 Fax: 31-30 2537623 E-Mail: kaptein@nmr.chem.uu.nl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ressource recovery from industrial waste water by cutting edge membrane technologies' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The ReWaCEM project aims at reducing water use, wastewater production, energy use, valuable metal resource recovery and water footprint by between 30-90% in the metal plating, galvanizing and printed circuit board industry. In order to achieve these goals, ReWaCem will adopt two cutting edge membrane technologies suitable for the requirements of closed material cycles approaches and recovery concepts in metal processing industry: Diffusion Dialysis (DD) and Membrane Distillation (MD) as an integrated hybrid process. This combination of existing technologies will be adapted to fit the requirements of 4 pilot demonstration sites in representative industrial applications of the metallurgical industry in order to evaluate the accomplishment of the ReWaCEM goals. Through the evaluation of the demonstration a highly attractive technological solution for low energy wastewater treatment will be available to be entered into the large and growing market of metal processing. This market will profit significantly from the technological outcome of the innovation action, with cost savings and environmental benefits as relevant rewards. In order to maximise impact, the project consortium was selected carefully to represent all relevant stakeholders in the quadrant of end users, scientific partners, associations and decision makers and SMEs. The consortium will establish a dissemination & exploitation board that will create a substantial network of interest groups from agencies, industry, research SMEs and research centres as well as universities. The successful exploitation of the results will lead to a post project up-scaling of the technology and a step by step market introduction. Part of ReWaCEM will be to mobilise all relevant stakeholders into promoting innovative membrane solut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Production cases on knowledge management tools implementation based on intelligent agents technology' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Knowledge Management systems can strongly contribute and determine the reorganisation of company production processes. The aim of the present proposal is an assessment of Anthropocentric Technology selection and Dissemination Action to foster the large scale utilisation of Knowledge Management solutions in the SMEs manufacturing processes through the following approach:1. Identification and selection of 10 knowledge management systems;2. Benchmarking analysis of selected KM systems;3. Definition and packaging of successful production cases Off: KM solutions;4. Realisation of self assessment interactive web based tool for manufacturing SMEs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Microorganism and enzyme Immobilization: NOvel Techniques and Approaches for Upgraded Remediation of Underground-, wastewater and Soil' (MINOTAURUS).

assistant: **Concept**

MINOTAURUS will deliver innovative bio-processes (bioaugmentation, enzyme technology, rhizoremediation with halophytes, and bioelectrochemical remediation), which are all based on the concept of IMMOBILIZATION OF BIOCATALYSTS (microorganisms and enzymes), to eliminate emerging and classic organic pollutants. The immobilization-based technologies will be applied to engineered (ex-situ) and natural systems (in situ) for the bioremediation of groundwater, wastewater, and soil. The selection and adaptation of modern physico-chemical, biological, and ecotoxicological monitoring tools combined to a rational understanding of engineering and enzymology/microbial physiology aspects is a pertinent approach to open the black-box of the our technologies. The reliable process-monitoring will constitute a solid basis to develop and refine our biodegradation kinetics models, which will be the mean to improve the predictability of performances to be achieved with our technologies. A key strength of MINOTAURUS is the possibility of direct implementation of our technologies at five EU reference sites that are confronted with pollutants (two technologies will be tested on-site during the first year). We will deliver not only a set of tools, techniques and processes which will enhance the ability of our communities to respond to the challenges of organic pollutants but also frameworks for structuring and making evidence-based decisions for the most sustainable and appropriate bioremediation measures. MINOTAURUS consortium consists of fifteen partners from eight European and Europe-associated countries. Eight research & education institutions, five SMEs covering the whole chain of our bioremediation approaches (production/monitoring of biocatalysts, bioremediation, and engineering), one lar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Additive Manufacturing Optimization and Simulation Platform for repairing and re-manufacturing of aerospace components' (AMOS) targeting Horizon 2020.

assistant: **Abstract**

This research project focuses on several key Direct Energy Deposition (DED) Additive Manufacturing (AM) processes that have great potential to be used as cost-effective and efficient repairing and re-manufacturing processes for aerospace components such as turbine blades and landing gears. This project aims to conduct fundamental research to understand the material integrity through chosen DED AM processes, the accuracy and limitations of these deposition processes, effective defect geometry mapping and generation methods, and automated and hybrid DED and post-deposition machining strategies. This project intends to connect repair and re-manufacturing strategies with design through accurate DED process simulation and novel multi-disciplinary design optimisation (MDO) methods to ultimately reduce the weakness of aerospace component at design stage and prolong their the lifecycles. Both powder-based and wire-based DED systems will be investigated to establish an across-the-board comparative study. The data collected through this comprehensive comparative study will be extremely valuable for the OEMs of this project (i.e. GKN, PWC, and HDI) to understand the pros and cons of these DED systems and will help them to select suitable repair and re-manufacturing strategies. The tests conducted in this research are also extremely beneficial for the SMEs in this project (i.e. Liburdi, AV&R, DPS) to validate their existing repairing systems and techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Support devices for the visually impaired person using a portable machine to transform bar code information into an audible speech.' in the context of a Fifth Framework call.

assistant: **Objectives**

The objectives of the project are:1. The development of a device able to read a bar code and to transcript this into audible speech2. The adaptation of existing bar codes carriers and the printing techniques:- to reach 1500 characters in a label of a size around 1,3% of a page (for example the label will not exceed 10 cm2 on a paper A4 format),- to easily locate the bar code by either a tactile or smart chip location module.3. The development of a portable device integrating:- A speech synthesis unit (already developed by T&I) with its power supplier unit- Modification from a 5V to a 3,3 V technology,- Availability in 6 languages: French, Italian, Spanish, Dutch, English, and German- Miniaturisation of the printed circuit- A bar code reader (chosen from existing ones) but optimised to reach a reading speed of less than 5s.4. Spreading of the coding technique and the associated reader to enable blinds and visually impaired to have access to a wide range of information.DESCRIPTION OF WORKTalking Bar Codes will use standard bar coding technologies and develop a solution to code the information of a document into two dimensional bar code and to print the bar code on the document. A handheld bar code scanner will be developed to transcribe the bar code information into audible speech: existing text-to-speech technology and bar code reading technology will be integrated into a low-cost and easy-to-use handheld device. The solution will support six European languages (Dutch, English, French, German, Italian and Spanish). The project will spread the use of both the new coding technique and the reader.MILESTONESThe coding technique to convert the information of a document into a two dimensional bar code symbol: 10cm for packaging.The requirements and the printing solution for se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The isis pulsed neutron facility' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Description:The ISIS Neutron Facility is the most intense pulsed neutron source in the world, and the only of its kind in Europe. ISIS operates 20 neutron instruments and over 600 experiments are carried out each year by more than 1200 scientists from many nations, in disciplines ranging from Biology and Chemistry to Physics, Materials Science and Engineering. At the same time the suite of neutron scattering instruments continues to be upgraded and expanded. A project to increase the proton current by 50% from 200mA to 300mA with a corresponding increase in neutron intensity is fully funded and in an advanced stage of implementation.Researchers supported under the IHP Access to Infrastructures Programme receive the full benefit from the ISIS User Support System: expert scientific and technical support by ISIS staff, and access to all ancillary equipment and resources such as state of the art sample environment equipment, safety advice and supervision, advanced computing support.Application:Access to the ISIS Neutron Facility is supported financially by the European Community's 'Access to Research Infrastructures Action of the Improving Human Potential Programme'. Applications for this support is available as part of the normal ISIS procedure for beamtime applications and requires the completion of the ISIS Application Form. Electronic versions of the application form are available on the World Wide Web (http://www.isis.rl.ac.uk).Project Manager:Uschi Steigenberger, The ISIS Facility - Rutherford Appleton Laboratory, Chilton, Didcot, Oxon OX11 0QX, United KingdomTel: +44-1235-445684Fax: +44-1235-445383E-Mail: C.J.Carlile@rl.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Creating a comprehensive functional map of the viral and host factors in HCMV infection' under Horizon 2020.

assistant: **Concept**

The herpesvirus human cytomegalovirus (HCMV), the largest known human virus, is a ubiquitous pathogen that persistently infects the majority of the world's population through the establishment of latency. Although asymptomatic in most healthy individuals, HCMV can lead to a severe congenital disease, as well as morbidity and mortality in immunocompromised adults. Despite the prevalence and pathogenicity of HCMV, many fundamental questions about this pathogen remain open. We still do not know the complete list of functional elements in HCMV's complex genome and how these contribute to infection progression and latency, we do not understand the determinants that govern infection outcome, and we are missing tools that will facilitate systematic dissection of the host and viral factors that are needed for HCMV infection in different cell types.In this proposal, we suggest to employ our expertise and to develop unique toolsets to shed light on the host and viral factors that regulate the HCMV life cycle. We propose to combine state-of-the art high-throughput tools with mechanistic studies to comprehensively characterize the viral elements that regulate HCMV progression (aim 1), decipher the determinants that dictate infection outcome (lytic vs. latent, aim 2) and develop and implement a sensitive screening platform that will facilitate easy dissection and characterization of HCMV essential components in any cell type (aim 3).The knowledge generated from these objectives will provide a clearer depiction of the different determinants that control HCMV infection and will generate new tools for the benefit of the community. These in turn could help to expand our therapeutic options. More broadly, with its comprehensive and complementary approaches, this work will provide a parad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'POWER AND ENERGY REDUCTION IN BUILDING BY USING ELECTROCHROMIC REGULATED GLAZINGS' to be submitted under Fourth Framework.

assistant: **Abstract**

Demonstrate effectiveness of electrochromic windows: optimise control strategies, check system energy saving potential, and test market acceptance of its aesthetics and durability. Project involves components implementation in varied conditions, Winter garden of new demonstration house in Brussels suburbs, and in two experimental buildings in Belgian and Mediterranean climates. Innovative window uses electrochromic glazing coupled with low emissivity glass to provide product with variable, controllable optical characteristics solar control in Summer, and transparent thermally insulating in Winter.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Participatory Open Social Innovation Through Interlinking Valuable Ecosystems'.

assistant: **Innovation**

Social innovation actors take on an important role in finding solutions for societal challenges. However, many social enterprises lack entrepreneurial skills and digitization of their products or services and there is still a lack of support for social entrepreneurs, which is due to the fact that many business support organisations have little understanding of the specific challenges and needs of social entrepreneurs. The social innovation and the technology innovation ecosystems are currently not well interconnected and mostly considered separate ecosystems with different skillsets. The POSITIVE project will counteract these factors by raising awareness about the benefits of social innovation and providing capacity building about social innovation and social entrepreneurship to the tech innovation ecosystem, thus creating the basis for better support for social entrepreneurs and a more inclusive innovation ecosystem based on mutual understanding. The project will also provide new opportunities for social entrepreneurs to digitise their products and services and to acquire new business skills through the organisation of an Open Innovation Challenge in three countries (POSITIVE Impact Challenge), which constitutes knowledge transfer from the tech into the social innovation ecosystem, with the specific purpose to support regional SI actors to access alternative means of financing. The POSITIVE project will also foster the interlinkage of the two ecosystems on a regional and European level through cross-fertilization, knowledge exchange and policy recommendations on how the POSITIVE Impact Challenge model can be replicated. Thus, the POSITIVE project can not only contribute to the strengthening of the social economy on different levels, but also make the tech innovation ec