RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular and Metabolic Mechanisms of Trypanosoma vivax Vascular Sequestration' (VIVASEQ).

assistant: **Concept**

Animal African trypanosomiasis (AAT) is a deadly vector-borne disease of livestock caused by Trypanosoma brucei, T. congolense, and T. vivax. T. vivax is the least studied but the most geographically widespread, driving epidemics across Africa and South America with major economic and social impacts. In the mammalian host, T. vivax exhibits unique vascular tropism through cytoadhesion to endothelial cells (i.e. sequestration), which promotes endothelial activation and tissue pathology. This host–parasite interaction requires both specific adhesion factors and energy to sustain binding under blood flow. Preliminary transcriptomic data from the host lab show that T. vivax undergoes marked transcriptional reprogramming during sequestration, with differential expression of adhesion factors, and upregulation of glycolytic genes, indicating that glucose metabolism supports vascular tropism. In VIVASEQ, I propose to elucidate the molecular and metabolic mechanisms underlying T. vivax sequestration, with the ultimate goal of functionally disrupting this process, therefore preventing disease. This will be achieved by: 1) identifying the candidate parasite molecules mediating sequestration, 2) characterizing the metabolic remodeling that sustains this interaction, and3) functionally targeting adhesion factors to disrupt sequestration. I will apply cutting-edge approaches not yet implemented in T. vivax research, including targeted mass spectrometry, ultrastructural expansion microscopy, metabolomics, and a host-specific vessel-on-chip model. VIVASEQ will provide fundamental knowledge to support the implementation of sequestration-blocking strategies to control AAT, whilst potentially uncovering evolutionarily conserved mechanisms of parasite-endothelial cell interactions with bro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cellular mechanisms of predictive processing and its effects on perception' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Predictive processing is a leading theory of brain function. However, despite several conjectures it is unknown how predictive processing is implemented at the neural level. We will try to understand the exact role of the computations of the layer 5 pyramidal (L5p) cells within the framework of predictive processing. The experimental paradigm and the computational model used here are designed to answer, whether L5p cells carry predictions, as the theory of predictive processing suggests, or are they responsible for some other computation. To this end we will a) adapt experimental paradigms used with humans to study probabilistic computations in the mouse model, b) measure the dendritic input and somatic output of L5p cells in mice, c) capture this activity with computational models and d) manipulate the apical dendritic input and somatic output of L5p through noradrenaline antagonists. The project allows us to understand the mechanisms underlying predictions and their effect on perception.


**Keywords:** Predictive Processing,  Layer 5 pyramidal cells,  Illusory perception
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovative processing of multiphase high temperature ceramics' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives and content The objective of the programme is to develop and characterise in-situ aligned ceramic materials formed by a novel extrusion process, to correlate their high temperature behaviour to theoretical and experimental models and to demonstrate commercial exploitability. Gas turbines and other industrial applications are limited both in efficiency and in environmental cleanliness by their operating temperatures, which are restricted by the upper temperature limits of metal alloys. Alternatives materials based on fibre reinforced ceramics are prohibitively expensive to produce and not sufficiently stable at high temperatures. Monolithic ceramics cannot be used for such structural applications because of their inherent brittleness. The proposed technology offers a cheap, rapid and effective means of producing a new family of structural materials capable of operating up to 1400 C, in air and without cooling. The material would be produced by solbased technology involving the extrusion, at room temperature, of a two phase material giving an aligned two-phase structure which could then be re-extruded to reduce the widths of the phases to the order of lOOnm Such tapes could then be assembled, consolidated and sintered to form a multi-phase ceramic material. The process would allow the microstructure to be controlled at a nanometer scale within each extruded filament and a more macroscopic control of the structure would be achieved at the stage of compaction and sintering. This type of structure is considered to be ideal for obtaining maximum strength and tenacity in brittle materials as well as limiting creep at high temperatures, which are indispensable properties for structural uses. It is proposed to show that this novel multiple extrusion process allows an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Defending the European Energy Infrastructures'.

assistant: **Concept**

Critical Energy infrastructures (CEI) protection and security are becoming of utmost importance in our everyday life. However, cyber and system-theoretic approaches fail to provide appropriate security levels to CEIs, since they are often used in isolation and build on incomplete attack models, resulting in silos-like security management fragmented operational policies. To face these challenges, DEFENDER will (i) model CEIs as distributed Cyber-Physical Systems for managing the potential reciprocal effects of cyber and physical threats (ii) deploy a novel security governance model, which leverages on lifecycle assessment for cost-effective security management over the time (iii) bring people at centre stage by empowering them as virtual sensors for threat detection, as first level emergency responders to attacks, or by considering workforce as potential threats. DEFENDER will adapt, integrate, upscale and validate a number of TRL 4-5 technologies and deploy them within a TRL7 integrated yet adaptable framework for CEI security, resilience and self-healing “by design”, with a view to address, detect, and mitigate cyber-physical threats. To this aim DEFENDER framework will combine a range of devices/technologies for situational awareness (fixed sensors like PMUs, mobile devices like drones and advanced video surveillance) (ii) intelligent processing for cyber-physical threat detection with (iii) a toolbox for incident mitigation and emergency response and (iv) Human-In-The-Loop for managing people interaction with CEI, while leveraging on blockchain technology for peer-to-peer trustworthiness. The effectiveness of DEFENDER will be extensively validated on a CEI lab emulator (RWTH, Germany) and on 4 real life demonstrators (in France, Italy and Slovenia) fully covering the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Definition of a common european analytical framework for the development of local agri-environmental programmes for biodiversity and landscape conservation' (AEMBAC) targeting Fifth Framework.

assistant: **Abstract**

The objective of the project is the definition of a common European analytical framework to develop local environmental-environmental programmes. The project will identify the performances of different agricultural systems in relation to the conservation of biodiversity and landscape in 7 different countries through identification and assessment of agriculture impacts over ecosystems environmentalmultifunctionality, using ecological and environmental-environmental indicators at environmental -ecosystem/farm levels. Based upon this information a methodology will be developed to identify environmental-environmental targets and measures (e.g. regulatory and/or economic tools), to incentives the supply of environmental goods and services by farmers and to disincentives unsustainable agricultural practices. Pilot projects will assess the management feasibility of the analytical framework and tools proposed for environmental-environmental measures by local farmers and administrators.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Policy-oriented and harmonising research activities in the field of primary immunodeficiency diseases (PIDs)' to be submitted under Sixth Framework.

assistant: **Abstract**

Primary immunodeficiencies (PIDs) belong to the group of rare diseases. Due to their rarity, they can only be studied through transnational studies. European research in the field of primary immunodeficiencies has a good track record and this application is built upon existing research infrastructures in order to maximise the scientific outcome and be cost-beneficial. The application focuses on four key objectives: 1. To increase our understanding of the aetiology of PIDs, and identify novel mutations and new disease genes. 2. To carry out epidemiological studies in order to determine the prevalence of PIDs in Europe. 3. To establish and evaluate harmonised guidelines for the diagnosis and treatment of PIDs. 4. To improve the awareness of PIDs among the European population. In order to achieve these aims we will develop a new, secure, Internet-based patient registry, which comprises several novel features and standards. This database will form a platform for studies of demographics, the harmonisation and development of new diagnostic and treatment strategies, and the identification of novel disease genes. This will also improve our knowledge regarding complex mechanisms involved in the immune responses.We believe that the outcome of this proposal will influence the field of primary immunodeficiencies in many respects. The results will benefit the European population, especially the estimated 60,000 patients suffering from these diseases. Hopefully the implementation of adequate treatment strategies throughout Europe will reduce the costs to the society. Moreover, we hope that many of the strategies and instruments that will be developed can also be used for the benefit of patients having other rare diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bidirectional Hyper-Connected Neural System' under Horizon 2020.

assistant: **Concept**

Current brain and neural interfacing technologies still face significant limitations to become accessibility tools that can benefit people. On the one hand, non-invasive neural interface technology (e.g. EEG, EMG) is intrinsically unidirectional and of limited capacity. On the other hand, invasive technology (e.g. percutaneous EMG, implanted nerve electrodes or intracranial electroencephalography) while allowing two-directionality and better performance still relies on complex surgical procedures.EXTEND aims at developing the novel concept of Bidirectional Hyper-Connected Neural Systems (BHNS) to extend the capabilities of neural interfaces with minimally invasive communication links between multiple nerves in the body and multiple external devices. EXTEND will realise BHNS by developing disruptive wireless neuromuscular (injectable) interface technology that enables distributed stimulation, sensing, processing and analysis of neuromuscular activity, the ultimate stance of the neural code of movement.The EXTEND project will showcase the advantages of this new technology in two applications: (1) tremor management in essential tremor (ET) and Parkinson disease (PD), and (2) neural interfaced assistive wearable robots for spinal cord injury (SCI). EXTEND will also work towards a community hub that brings together stakeholders to create an innovation ecosystem that can nurture the fast development of neural interfaces around the new concept.


**Keywords:** Implantable Neural Interface, Neural recording, Neural stimulation, BNCI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of selective catalytic oxidation sco" technology and other high temperature nh3 removal processes for gasification power plant ('AMMONIA REMOVAL')"' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Most renewable fuels contain nitrogen, which will convert to ammonia during gasification. This ammonia will form NOx emission during gas combustion in biomass gasification power plants, where hot gas cleanup is used. Hence, the objective of this research is to develop the two main technologies for ammonia removal in gasification plants. These are SCO (Selective Catalytic Oxidation) and nickel catalyst technologies. The research will be carried out by the European consortium consisting of research institute, three universities and three industrial partners. Fundamental laboratory studies together with testing in real gasification gases using bench-and pilot-scale gasifiers and slipstreams in commercial plants are used to produce the information needed to evaluate the technical and economic feasibility of studied technologies.1)Better SCO catalysts were found than originally was expected. Metal/alumina catalysts with varying properties were prepared and their applicability for the SCO process was characterized. The most promising catalyst identified was Cu/alumina. In addition, a ZrO2 catalyst was found to be suitable for simultaneous tar and ammonia decomposition giving relatively high conversions for the both impurities. The SCO process was also tested in real gasification gas atmospheres. The results indicated that the ZrO2 catalyst activity with real gases is comparable to lab scale results.2)Feasible operating window for nickel catalysts was identified. These catalysts were tested in product gas lines of small-scale gasifiers. Reactor model for nickel monolith was developed so that the effects of various operation conditions and the behaviour of the monolith could be studied. The most important operational parameters that affected achievable ammonia and tar conversio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CETOCOEN Excellence' (2014-2020).

assistant: **Innovation**

The aim of this project is to exploit research capacities built in Central Europe with a support of the European Structural and Investment Funds and develop a cutting-edge research platform capable of addressing major scientific and societal challenges of the contemporary Europe in the area of Environment and Health. It will enhance a scientific value of existing regional population studies and turn them into the accessible source of valuable information by developing sustainable biobanking platform and harmonizing their protocols, questionnaires, and standard operation procedures to allow for their joint assessment and interpretation of results. Existing research programmes will be expanded to address questions related to a wider range of factors (generically called exposome) impacting human health and wellbeing. To identify new biomarkers of exposures, effects, and susceptibility to pathologies, innovative approaches to the assessment of multiple exposures have to be developed including omics technologies, novel methods for integrative analysis, software tools and computational models, chemical sensors and triggers allowing for tracing such processes in biological systems. This innovative research is well aligned with the European and national strategic priorities and documents (including the National Innovation Strategy), and will generate substantial new knowledge needed for prioritisation of future research and policy actions in the area of chemical management as well as practical tools applicable in health protection, prevention, diagnostics, and intervention with the aim of minimizing the burden of disease, improve the health and well-being of citizens and lower health costs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Fostering Optimal Regulatory Compliance for Cryptocurrencies: An Interdisciplinary Approach'.

assistant: **Concept**

The project ""FORCE"" - Fostering Optimal Regulatory Compliance for Cryptocurrencies: An Interdisciplinary Approach - addresses the urgent need for innovative Anti-Money Laundering (AML) systems tailored to the rapidly evolving cryptocurrency ecosystem. Cryptocurrencies, including decentralised finance (DeFi) platforms, have significantly changed the global financial landscape, enhancing financial inclusivity and operational efficiency. However, these technologies' pseudonymous and decentralised nature also creates vulnerabilities that traditional AML systems cannot adequately address. This project aims to bridge this gap through an interdisciplinary research program combining blockchain analytics (business), artificial intelligence (AI), quantum-safe cryptography (cybersecurity), regulatory compliance frameworks (legal), decentralised finance (finance), digital EURO (business and management), education and training. By uniting expertise from academic institutions and dynamic SMEs across Europe, the project will facilitate the development of real-time, efficient, and secure solutions to combat money laundering and financial crime in cryptocurrency markets. Additionally, the project will promote cross-border collaboration, a key priority of the Marie Skłodowska-Curie Actions (MSCA) Staff Exchange Program, ensuring that these AML systems are globally applicable and aligned with international regulatory frameworks.The overarching objective of FORCE is to create novel, scalable, and future-proof AML solutions for cryptocurrency ecosystems. Specifically, the research will focus on the following objectives: blockchain analytics & AI for AML, quantum-safe cryptography, global regulatory compliance, and cross-border AML enforcement. ""


**Keywords:** Cryptocurrency AML, Blockc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Utilisation of small pelagic fish for human consumption. Process development for large scale production of low cost food item'.

assistant: **Innovation**

Most of the small fish that is caught in the Northeast Atlantic area, like capelin, sprat, herring, or blue whiting, is turned into fish meal and fish oil. This applies to yearly catches of more than 4 million tons i.e. more than 30 % of the total Northeast Atlantic fish catches. In order to upgrade significant amounts of this high value and low cost protein source, the project is aimed at the development of a cost effective production process for low cost food items, in particular salted/dried whole fish, using the high quality part of industrial fish catches. Similar food products are common in many southern and far eastern countries and can be an important source of animal protein in areas where big parts of the population have no access to high value protein sources. A market volume in the order of 20 to 50 thousand tons per year is expected, if the products can be offered at similar price levels as sun dried fish or soya protein and if the products meet consumer expectations and the requirements of the distribution chain.To fully benefit from the low price of industrial fish catches, the processing has to be extremely cost effective. A significant reduction of total processing cost is expected from the optimisation and innovation of current process steps, the extension to industrial size, the production on shore near the catching grounds, and from a high degree of mechanisation.The objective of the proposed project is to provide innovative processing knowledge in the form of methods and parameters for the main steps of the production process, in particular: low cost and high volume storage of landed fish during several months to extend processing period beyond catching season optimised drying adapted packaging for stable transport and distribution in tropical count