RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nanoscale Thermo Optical Sensing' in the context of a Horizon 2020 call.

assistant: **Objectives**

NaTOS: Nanoscale Thermo Optical Sensing is the concept of a new truly label free bio-sensor device capable of monitoring transient molecular interactions. The sensor utilizes plasmonic gold nanorods (NR) as both nanoscale heating source and optical near field sensor. Proteins and enzymes will be monitored as they change the intensity scattered by a single NR as they diffuse through the nanorod's nearfield.The simultaneous laser induced and thus tunable heating of the NR will induces a nanoscale temperature gradient that allows to probe the analytes with respect to their thermophoretic behavior. This analyte specific behavior provides specific thermophortic fingerprints which will be used to identify and distinguish between different proteins and in further extend also to monitor the interaction between different species of analytes. This novel type of sensor does not require fluorescent labels nor does it rely on tethering of specific receptors and the consequent binding of analytes to the NRs. In contrast to current state of the art techniques this truly label-free sensor does not suffer from binding induced life time restrictions and can obtain statistical significant datasets without the requirement, but with the possibility of multiplexing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reinforcing eGovernment services in Baltic States through legal and accountable digital Time stamp' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Time Stamping Authority being integral part of eGovernment services using electronic signatures is to large extent responsible for the confidence and accountability of the service. Technological solutions for time stamping services need to be proposed as integral for Enlarged Europe approach overcoming obstacles hampering eGovernment services acceptance by end users: low trust on existing solutions due to disputed time stamp accountability and fragmentation of eGovernment services on European level.BALTICTIME project is designed to enhance the confidence on time stamping service through adopting capacities of Time Standard Authorities of EU metrology system as most authoritative and reliable backbone for Time Stamping Authority. In such a way level of the confidence and accountability of the service eligible for employment in eGovernment services will be created and integral for Europe solution having strong potential to overcome existing fragmentation will be introduced. The overall objective of the BALTICTIME project is to develop the legal and accountable digital time-stamping (DTS) system providing the layer of Trust in eGovernmental transaction environment.It will be achieved through implementation of two-phase project:- Development of time stamping system based on National Time Standard Authority ensuring auditable, accountable and transparent time stamping service;- Demonstration and evaluation of BALTICTIME system performance for time critical functions in eGovernment services with possibilities for cross-border time stamping service.Project objectives were formulated taking into account integral approach on ongoing eGovernment activities in Enlarged Europe and in compatibility with the actions undertaken in Baltic States region by structural funds schemes and F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Improving cereal yield predictions under drought: root diameter as a predictor of plant water uptake across scales.'.

assistant: **Objectives**

As droughts are becoming more frequent and severe, there is a call for adaptation strategies that enhance the crop’s resilience to these climate conditions. One pathway to do so is to select crops whose root system optimize the soil water uptake. However, the identification of adequate ideotypes is compromised by the limited understanding of the structural drivers controlling the water uptake from the root to crop scales. This knowledge gap is attributable to the multiscale and nonlinear nature of the soil-plant interactions. DROOGHT aims to address these gaps by identifying the dominant drivers of the complex below-ground processes in cereal crops. Based on suggestive pieces of evidence, the project builds on the primary hypothesis that the distribution of the root diameter within a cereal root system is an indicator of its structure and functions at the organ and field scales. The value and groundbreaking nature of such an indicator would lie in its simplicity: diameters are one of the easiest root traits to measure in any field set-up and at large scales. I will test this hypothesis and identify the dominant structural root traits controlling plant water uptake dynamics under water-limited conditions using complementary in silico and in vivo approaches. The outputs of this project will be (i) a novel multiscale computational framework that links local root structures to plant and crop functions; (ii) a phenotyping pipeline that links root structure to function; and (iii) the identification of cereal root properties favorable to higher yields across European pedoclimatic conditions and climate change scenarios. More broadly, this project will allow a significant step forward in our understanding of the role of root systems' structural traits on water uptake dynamics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Closed Loop INsulin Infusion for Critically Ill Patients' (CLINICIP) targeting Sixth Framework.

assistant: **Abstract**

Healthy people can develop atypical physiological symptoms under critically ill conditions, e.g. in the intensive care unit (ICU). Due to shock and trauma as a consequence of the surgery, the glucose concentration is likely to rise significantly comparable to the symptoms known as insulin-dependent Diabetes Mellitus. Similar to diabetes mellitus, the high glucose level needs to be treated with external insulin. According to a study in Belgium the intensive insulin therapy treatment cuts the mortality rates by 42% compared to standard insulin therapy for ICU indication.The project provides an intelligent system for improved health status monitoring of critically ill patients. A local system will be developed comprising biosensors for the determination of glucose in whole blood. Based on the continuous measurement, an adaptive control algorithm generates advice and thus represents a decision supporting system in an early project stage. Within a closed loop system intensified insulin treatment will make use of calculation results leading to the external regulation of glucose. In addition to the approach of controlling the glucose concentration, a minimally invasive treatment will be investigated. A number of biosensors for the determination of most important parameters such as lactate, carbon dioxide, oxygen and pH will be used to characterize adipose tissue.In order to support the implementation of intensified treatment in an optimal way, a telemedical infrastructure will be developed. This includes a knowledge sharing environment, allowing the involved clinical centres to store and share their newly generated knowledge. Additionally all data resulting from clinical trials will be saved on the server. In later stages of the project, access to the data and the derived clin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High-Performance Mass Spectrometry Using a Quantum Sensor' under Seventh Framework.

assistant: **Concept**

Mass spectrometry is one of the most important, essential and basic techniques in modern science. This is because the mass of a fundamental particle is a fundamental property of the particle itself, or, in a composite quantum mechanical system such as an atom, the mass is the sum of the masses of all its building blocks minus the binding energy between those constituents. The binding energy reflects all physical forces acting in such a quantum system.The most-advanced instrument for high-accuracy mass determinations is the Penning trap using the fundamental techniques of cooling and storing. The most highly developed Penning trap presently at hand needs still a drastic improvement and ground-breaking ideas in order to achieve the two scientific goals of the present grant application: (i), determination of the Q-value of the decay 187Re to 187Os with an accuracy of delta_m/m = 10^(-11) as required for the MARE I campaign aiming at a determination of the mass of the electron antineutrino via a very careful determination and analysis of the beta spectrum; (ii), measurement of the masses of superheavy nuclei (Z less or equal to 118) produced by hot fusion process enabling a clear assignment of the proton number to the different isotopes (and by this also the naming of the elements discovered by hot fusion) and making possible tests of state-of-the-art nuclear theories.A novel method, called quantum sensor, is proposed to measure the mass of a single ion with ultimate accuracy and unprecedented sensitivity while it is stored and cooled in a trap. The new device consists of a single calcium ion as sensor, which is laser-cooled to mK temperatures and stored in a trap connected to the trap for the ion under study by a common endcap. The motion of the ion under investigation is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Genes expressed early in plant cell determination' (1994-1998).

assistant: **Concept**

Mesophyll cells from the leaves of Zinnia elegans, when cultured in a medium containing a specific ratio of auxin to cytokinin, directly transdifferentiate into tracheary elements. Cells pass through an irreversible point of determination during this process and I have identified both proteins that are secreted into the medium at the point of determination, as well as some cDNAs whose expression appears to be determination-dependent. My project will be to understand the nature and function of the corresponding genes and products in the determination events at both a molecular and a cellula level. Further work on the differential screening of cDNA libraries will allow me to define marker for stages of determination and subsequent differentiation. A focus of my work would be on a 87kDa protein that I have identified as being a major secreted protein only at the point of determination under inductive conditions. Immuno-screening of expression libraries will enable me to characterise the corresponding cDNA and will allow me to examine the expression and function of this protein both in intact plants and at key stages of determination in culture. If time permits the work will expand into two areas, characterisation of genomic clones and a search for homologues in Arabidopsis in order to generate transgenic plants for over- and under-expression of the corresponding message. The project will involve training in a wide variety of cell biological, immunological biochemical and molecular biological techniques, and will help me to begin to understand the molecular basis for cell determination in plant development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Statistical modelling and estimation for spatiotemporal data with oceanographic applications' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This fellowship is concerned with building new statistical modelling and estimation procedures that are appropriate for Big Data challenges with high-dimensional dependent data. The new methods will be applied to large oceanographic spatiotemporal datasets leading to important application benefits in global climate modelling.  The methodological contribution centres on building physically-motivated stochastic processes that capture multivariate dependence structure from complex high-dimensional data sets. Estimation procedures are then developed to capture heterogeneity in spatiotemporal data, while properly accounting for practical issues such as irregularly-sampled data in space and time. Such modelling and estimation procedures provide great interpretability and meaningful summaries from the complex data sets we observe. The societal benefits include improved global climate modelling and improved responses to environmental disasters such as oil spills.These advances will be achieved through interdisciplinary collaboration, with the fellow working closely with world-leading experts in oceanographic data in the US during the outgoing phase, and then consolidating these developments at the UCL Department of Statistical Sciences in the return phase. The fellow will therefore gain experience in developing relevant new statistical methods for a pressing Big Data challenge, and will then return to Europe where this training will significantly develop the fellow’s ability to produce cutting-edge research at the frontier of statistics and numerous applications involving complex high-dimensional data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Large fresnel number semiconductor lasers' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content The applicant, Dr Huyet wishes to combine the valuable knowledge of large aperture lasers, he gained under Tredicce, with the impressive experience of Professor McInerney in broad area semiconductor lasers. This project is both motivated by technological applications and scientific understanding of large Fresnel number semiconductor lasers. The two specific area considered, wide stripe semiconductor lasers and vertical cavity semiconductor lasers optically pumped, will couple extremely well with the current projects under thee direction of Professor McInerney. The experiment will be carried with Dr Andrew Kent, another TMR fellowship working on the theory of large aperture semiconductor lasers, in order to understand the complex behavior of these lasers and also in order to obtain a stable high output power Training content (objective, benefit and expected impact) Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Simulation of Hydride-Induced Crack Growth in Hydride Forming Metals under Loading and Temperature Transients' (HYDEMBMETAL) under Sixth Framework.

assistant: **Objectives**

Hydride-induced embrittlement in metals is a complicated phenomenon involving the coupled processes of hydrogen diffusion, hydride precipitation, non-mechanical energy flow and material deformation. The training objective of the proposed fellowship is the enhancement of the theoretical/numerical skills of the incoming researcher, who has strong experimental background in the field. The scientific objectives are: the development of a theoretical/numerical model for the simulation of hydride-induced embrittlement and sub-critical crack growth, by considering the coupling of the physical processes and material microstructure; the prediction of important quantities of hydrogen embrittlement, such as incubation period, threshold stress intensity factor and crack growth velocity, as well as their dependence on environmental, geometrical, loading and material parameters; the application of the model for the prediction of the embrittlement and fracture of zirconium alloys in fracture tests as well as for the integrity evaluation of high burn-up nuclear fuel cladding under power transients. The developments will be based on the extension of models, already developed in the host institution of the incoming phase. The theoretical predictions will be evaluated against existing experimental data as well as against experiments, which will be performed in the reintegration host organization.The theoretical/numerical tools, to be developed in the project, are also useful in investigating the embrittlement of titanium alloys of importance to aerospace industry. The present study is also expected to contribute to the research efforts related to the use of hydrogen as a main source of energy, friendly to the environment. Finally, the state of the art models/tools, to be developed in the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamic behaviour of composite materials for next generation aeroengines' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main objective of the DYNACOM (Dynamic behaviour of composite materials for next generation aeroengines) training network is to set up a European Industrial Doctorate (EID) programme on the design of the next generation of structural composite materials for high strain rate applications. This will be achieved by the development of a consistent, physically based multiscale simulation strategy informed by the dynamic properties of the constituents (fibre, matrix and fiber/matrix interface) measured with a novel micromechanical testing methodology. Two of the major milestones of this EID are: (1) to offer early stage researchers (ESRs) a multidisciplinary and intersectorial training with the objective of establishing a new design paradigm in structural design of composite materials and (2) to provide the European industry with new tools towards a knowledge-base incorporation of composite materials into new components, without the need of inefficient and expensive traditional trial and error approaches. In this sense, the technological focus is put into the introduction of new composite components into the next generation of aeronautical engines, but the implications are numerous in other sectors where composite materials have been identified as a key enabling technology, such as in transport, energy generation and biomedical applications. To accomplish this, the programme brings together one research institution, two industrial partners, one academic institution and a non-profit organization. The joint academic and industrial training program offered by this EID will ensure that the innovative aspects of the research work find a quick industrial integration and will provide the early stage researchers with a truly interdisciplinary and intersectoral training, enhancing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The elucidation of the nuclear receptor gene regulatory network in mouse microglia' (MNRGN), addressing dissemination and exploitation.

assistant: **Impact**

Nuclear receptors (NR) constitute a large transcription factor (TF) family with ~50 NRs identified in human or mouse. NRs have crucial roles in multiple tissues and biological processes. Consequently, misregulation of NR gene expression has been linked to several severe pathologies including cancer and neurodegenerative diseases. Despite their pathological importance, the core NR gene regulatory network (i.e. the protein-DNA interactions or PDIs controlling the expression of NR genes) has been very poorly studied. We will initiate the elucidation of the NR gene regulatory network by focusing on primary microglial cells as a non-transformed, and homogeneous model system. Microglia are poorly characterized macrophage-like brain immune cells, which may have both neurotoxic and neuroprotective properties. The majority of NRs exhibit a very dynamic expression profile in activated macrophages. Together with our preliminary data, this suggests that NRs may play a central role in microglial gene regulatory networks as well. The biological question of this proposal is to understand “which, when, and how NRs are expressed in microglia in response to neurotoxic stimuli”. We will (1) identify the temporal gene expression profiles of NRs in activated microglia; (2) identify the TFs controlling differentially expressed microglial NRs by uniquely combining two novel technologies (chromosome conformation capture and high-throughput PDI screening), whose respective co-inventors will both be involved in the project; and (3) experimentally validate the detected PDIs in microglia using siRNA and ChIP. The resulting list of high-confidence PDIs will be used to generate a first microglial NR gene regulatory network. The latter can be used for future modeling efforts to predict how the networ