RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-wavelength regeneration technologies for advanced modulation optical signals' under Horizon 2020.

assistant: **Concept**

The ultimate goal of this Fellowship, entitled “Multi-wavelength regeneration technologies for advanced modulation optical signals” (INNOVATION) is to train a talented researcher through a research project focused on the development of all-optical regeneration subsystems handling multi-wavelength and advanced modulation signal waveforms in a single device. Focusing on the hardcore issue of multi-wavelength regeneration “how to reduce nonlinear crosstalk for spectrally efficient advanced modulation signals”, the Fellow proposes pioneering concepts including novel nonlinear devices (nonlinear multi-core fibres and phase-sensitive parametric oscillator units), new crosstalk suppression methods (spatial-division-multiplexing and bidirectional oscillation methods). The resulting regeneration subsystems will dramatically reduce cost and power consumption by combining the nonlinear processing with high-speed multiplexing. Finally, the system testing will demonstrate a multi-wavelength (>8 channels), multi-phase-shift-keying (MPSK) signal regeneration in a commercial network, which offers a high-capacity and green technology alternative to core switching nodes. The INNOVATION outputs will significantly increase the competitiveness of European communications industry in broadband technologies.     The Fellow – Dr. Feng Wen – will be trained in the fast-growing field of all-optical signal processing, receiving unique training experiences at the host: Aston Institute of Photonic Technologies (Prof. Sergei K. Turitsyn), and industrial partners: Xtera Communications (Dr. Stuart Barnes), France Telecom (Dr. Erwan Pincemin) and OFS (Dr. Lars Grüner-Nielsen). The Fellow will gain a multidisciplinary skillset in telecommunications, as well as fibre-optic and other industrial fields. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Safety assessment and lifetime Management of industrial Piping Systems' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Our industrial infrastructure is aging affecting society, economy and industry. Risk assessment and lifetime management gains importance with the progressive aging of industrial installations. The overall objective is to develop a complete integrated monitoring system that allows to rate industrial piping systems over their whole service life and to increase the general safety.The goal is to reduce investment cost for maintenance, inspection and loss of production as well as to limit accidents, hazardous t o mankind and environment. This proposal addresses important industrial lifecycle issues of the nuclear industry and the sector of chemical plants. Current, visual inspection based, methodologies shall be replaced by online sensor and decision support systems. No limit for the assessment throughout the lifecycle shall remain. The conceptual objective is to demonstrate the opportunities for the advanced technology to deliver a radical new approach to the lifecycle control and maintenance of structures. This will be achieved by showcasing the optimisation of piping systems in industrial installations that is enabled through a new rating paradigm for risk assessment, management, maintenance and retrofit. A complete integrated monitoring system will allow to r ate industrial piping systems over the whole service life and to increase the general safety.One of the main obstacles in pipe monitoring is the existence of non accessible parts of the system, for example if pipes are passing river basins, running subsurface or inside concrete structures. The objective is to use novel technologies like acoustic emission, guided mechanical wave propagation, tomographic imaging and flexible piezoelectric fibre sensors to overcome that obstacle. The fibres are produced in a nanoscale
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The first medical device for non-invasive detection and monitoring of infant meningitis' (NEOSONICS), addressing dissemination and exploitation.

assistant: **Impact**

Meningitis is a life-threatening disease that can kill in a matter of hours or cause life-long disabilities if not detected promptly. Infants (<12 months) are the most vulnerable population with a compromised immunologic system. Although the incidence is relatively low in industrialised countries, neonatologists only count with lumbar punctures as the gold standard method to detect the disease being invasive, risky and cost-inefficient. NEOSONICS is a patented first-in-class medical device based on high-frequency ultrasound to non-invasively detect and monitor infant meningitis. The hand-held device is placed on the open fontanelle of a baby and, due to proprietary coupling materials and in-house developed machine learning algorithms, detects the level of white blood cells in the cerebrospinal fluid at a sensitivity of 100%. With NEOSONICS, LPs will be limited to only a few patients with infection (and no LP contraindication) that will be non-invasively assessed with our innovation.


**Keywords:** Newborns,artificial intelligence,ultrasound technology,Machine learning,white blood cell,screening tool,infant meningitis,Body fluid infection,clinical validation,medtech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Performance of Soft Beach Systems and Nourishment Measures for European Coasts' to be submitted under Fourth Framework.

assistant: **Abstract**

The use of shore nourishment and dune restoration for coastal hazards management will likely increase significantly in the European Union over the next decades. It is prudent for coastal management authorities and the European Commission to begin to consider fundamental design, maintenance and performance assessment necessary for objective evaluation of such nourishments. Consistent application of evaluation criteria are necessary to accredit such projects in the identification of coastal hazards (flooding and erosion). The objectives specified in research area B (2) - research task 1 acknowledge this need and the present project directly contribute to the realization of these objectives. More precisely, our objective is to develop a new methodology to predict the medium (several months) and long ( a few decades) term performance of artificial nourishment schemes by introducing reliable and validated numerical modelling tools. These tools will be solid and general enough to be able to deal with a wide variety of field situations from dune restoration to shoreface nourishment including or not supporting measures. To reach that goal, the three existing sources of knowledge in nearshore oceanography, namely field observations, large-scale physical modelling and numerical models will be used and integrated. Practically, the project will be divided into four topics with specific objectives. TOPIC A: Overall integration and scientific management of the project. The main results of the projects will be integrated here to provide an update of the design part of existing beach nourishment manuals and recommendations on the use of soft beach systems and supporting measures in coastal management schemes, TOPIC B: Analysis of field data. An inventory of data and information on exis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Molecular basis of the transcriptional activation and repression function of the tumour suppressor p53'.

assistant: **Objectives**

The tumour suppressor p53 is the most frequently mutated gene in human cancer. It is involved in a large number of cellular responses upon stress-signals leading to growth arrest, apoptosis, DNA-repair senescence or differentiation. Although many target-genes have been described, it is still unresolved how the different choices of target-genes and the subsequent cellular responses are brought about. Furthermore, while a large number of p53-target genes for transcriptional activation were identified, its sequence-specific transcriptional repression function is not as well documented. The here proposed research plan would contribute to our understanding of how these choices between transcriptionally activated and repressed genes are made in viva upon specific stress-signals. To this end the selective assembly of gene and stress-specific p53-coactivator and co repressor complexes will be studied in vivo as well as the genomic environment of the various transcriptional responses.Furthermore, the p53-transcriptional repression function will be analysed, identifying the general mechanism of p53-transrepression as well as bona fide repressed target-genes and their biological function. Finally, the regulatory mechanisms of the choice of target-genes and of the transcriptional complex assembly will be studied in a cellular environment elucidating the specific processes that ultimately lead to a distinct stress-response in a cell. In order to study the molecular basis of p53's transcriptional activation and repression function it will be of enormous importance to perform this work in an environment that is internationally known for its work and expertise on transcription.The practical and theoretical support of a basic transcription laboratory will allow the applicant to be compe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'AI-centric Server on Chip for increasing complexity and scale of AI inference applications, enabling the scale of real-life AI applications.' in the context of a Horizon Europe call.

assistant: **Objectives**

AI holds immense promise across a wide range of applications, however, putting AI to work at scale remains a challenge. The main problem with implementing scalable AI deployment is that the current AI inference architecture is unsuitable for performing hyperscale computations due to complexity of deployment and total cost of ownership. New AI computing architecture is needed to enable the deployment of AI applications to realize its complete potential. NeuReality has developed NR1, an innovative Server-on-a-Chip solution in an AI Centric architecture and NR1 SDK, to facilitate the deployment of AI at scale. The unique architecture allows AI-optimized, simplified and democratized infrastructure with cost, power and performance optimization of access to AI computing resources, thereby enabling the deployment of AI inference. During the EIC project, NeuReality will finalise the development of NR1 and validate the optimized chip in operational settings for further commercialisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'European comparative genetic resource'.

assistant: **Concept**

At the end of 1996 two large scales ENU mouse mutagenesis projects were initiated in Europe.The goal of both screens is the production of mouse mutants wich will allow a better understanding of the molecular basis of such inherited diseases. So far, only a small percentage of the newly isolated mutations have been or are currently mapped be- cause of limited funding.Under the umbrella of EuroCOGENT,two projects (EuroComp and EuroGenet) will be launched to map a large number of mutant mouse lines.Modifier screens will be started to mimic complex diseases in man.In addition,databases will be developed and integrated and advanced genotyping and mutation detection methods will be developed. This will create a unique resource for the scientific community and pharmaceucital industry.Whilst these resources for creating and exploiting mouse mutants existing in Europe are so far unmatched world-wide,it appears necessary to ensure their consolidation and efficient utilisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'How biochemical networks encode biological specificity: Modulation of cell migration by isoform specific ERK and Akt signaling' (BIOSPEC).

assistant: **Concept**

Understanding how biochemical signaling networks encode biological specificity is a fundamental challenge for biologists in the 21st century. Genome sequences by providing the “parts list” for such signaling networks, were expected to advance insight. However, it has become clear that to understand specificity analyzing only the “parts list” is not enough; it is the complex orchestration of these parts’s expression, interactions, activation, and deactivation in both space and time that encode biological specificity. Thus, understanding the biological specificity code requires investigating the spatiotemporal dynamics of biochemical signaling networks. This proposal focuses on understanding how the spatiotemporal dynamics of epidermal growth factor (EGF) gradient-induced signaling and associated feedback loops encode a cell’s decision to migrate and invade. A particular focus is on the isoform-specific roles of ERK1, ERK2, Akt1, and Akt2. Traditionally, these protein isoforms have been assumed to have very similar roles in the phenotypic response to EGF signaling. However, our preliminary data show that these isoforms have very distinct, opposing roles for control of EGF gradient-induced cell migration in an aggressively migrating mammalian cell line. To measure, interpret, and understand EGF gradient-induced signaling and the resultant cell migration, we propose using an interdisciplinary, systems biology approach combining modern biochemistry, quantitative mass spectrometry, live-cell imaging, spatially-resolved mechanistic modeling, and empirical data-driven modeling. Model-based experimental design will be the hub that connects modeling with experiments through an iterative model building cycle. As result we hope to gain a mechanistic understanding of how EGF gradien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Creating Versatile Metallo-Enzyme Environments for Selective C-H Activation Chemistry: Lignocellulose Deconstruction and Beyond' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The availability of a versatile catalytic platform to precisely target and functionalize individual C-H bonds in complex organic molecules would revolutionize our synthetic strategies, leading to streamlined routes to high value chemicals and supporting the development of a ‘greener’ chemical industry. Although an impressive range of C-H functionalizations can be achieved with small transition metal complexes, site selectivity is often determined by features of the substrate, and not by the catalyst. A general approach to achieve the more aspirational ‘catalyst controlled’ transformations requires molecular recognition elements within the catalyst which: a) allow precise substrate orientation and b) can be tuned to alter selectivity. In principle, these requirements could be perfectly addressed by protein catalysts which can be readily adapted via laboratory evolution. However, enzyme engineering strategies are currently limited to Nature’s twenty amino acid alphabet, severely limiting the range of metal co-ordination environments, and thus catalytic activities, that are accessible within proteins. In enzC-Hem, I will exploit advanced protein engineering technology available in my laboratory to install ‘chemically programmed’ ligands and/or noble metal co-factors into selected enzyme scaffolds. I will show that the resulting C-H activation catalysts can be systematically optimized via directed evolution with an expanded genetic code using modern ultra-high throughput methods (>100 variants per second), yielding biocatalysts with augmented selectivity/activity profiles. Thus my approach merges the broad range of C-H functionalizations accessible with small molecule catalysts with precise control of selectivity provided by proteins. The biocatalysts developed will address
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Clothing manufacturing 4.0 – Changing the way we make fashion', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The clothing industry, plays an important role in the EU manufacturing industry, employing 1.7 mn people and generating an annual turnover of €166 bn. However, it is the second largest polluting industry in the world, mostly due to its current clothing production model, which leads to overstock, huge upfront costs, long lead-times, only being economically viable for large brands, who represent less than 10% of the industry. In fact, with this model, 30% of garments produced are never sold and end up in landfills or burned by clothing brands (polluting even further). This traditional slow production model was partially viable in a world where fashion trends were ruled by brands, and customisation was not an option. This has changed today however, with fashion trends changing faster than ever, and being now ruled by influencers and social media. Besides, demand for unique designs and short lead times renders the traditional model obsolete, making it even harder for SMEs to stay afloat.Rodinia Generation Aps is leveraging state of the art technologies as digital printing and automated textile cutting, to develop rodinia, a game-changing digital printing apparel production process (patent-pending) linked to a pioneering stringing-technology (patent-pending). Our production-process is 90% automated, applicable to any digital printing production line that includes a digital printer, a heater and a cutter, and managed by our proprietary cloud-based ""Clothing Manufacturing Efficiency"" software. It cuts production time by 98% and costs by 80%rodinia is the first solution that allows SME clothing brands to set up own micro factories and produce themselves their own clothes. Most importantly, apparel manufacturers and SME clothing brands will be able to adopt an on-demand just-i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'When Soft Matter Goes Really Soft – A New Paradigm for Star Polymer Self-Assembly' (2014-2020).

assistant: **Concept**

Biologic supramolecular assemblies, e.g., virus capsids and multiprotein complexes, show unprecedented complexity compared to man-made  structures. A key feature of the building blocks facilitating the emergence of this structural complexity is their deformability. This enables them to reconfigure during assembly to find optimum orientations within the superstructure. Here, I propose to exploit the concept of reconfigurability as design criterion for developing a new class of colloidal building blocks. Where currently available hard particles fail to form macroscopic structures due to lack of building block uniformity and undesired metastable states encountered during assembly, introducing flexibility will prevent these adverse characteristics. The envisioned building blocks are based on polymer grafted cores, where the attached polymers arms comprise solvophilic and solvophobic blocks. The limited number of arms have significant conformational freedom, a feature absent in traditional hard particles. The solvophobic segments, located at the particle’s periphery, drive spontaneous polymer micro-phase separation into patchy domains which are then locked into place. These patches imprint directional interactions to guide self-assembly and are linked to the core via flexible solvophilic polymers, enabling patch fluctuations. The resulting patch adaptability prevents the system from getting trapped in non-equilibrium states and relaxes stringent requirements on geometric uniformity, promoting the formation of long-range ordered assemblies. Following simulation studies, these soft particles should have propensity to order into ‘open’ (quasi)crystalline lattices providing unique photonic, mechanical and porous characteristics.Complementing my physical/polymer synthetic backgro