RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Designing long-term systemic transformation frameworks for regions – Accelerating the shift towards climate neutrality'.

assistant: **Innovation**

The ambition of the TRANSFORMER project is to design long-term systemic transformation frameworks for regions across Europe in order to accelerate the shift towards climate neutrality. At the onset of the project, a conceptual framework will be developed by mapping, defining, and categorising Transition Super-Labs (TSLs). Actual TSLs will be piloted in four regions: the Ruhr area, DE, Emilia Romagna, IT, Lower Silesia, PL and Western Macedonia, GR. The project will develop a roadmap blueprint, a toolkit (incl. matchmaking mechanisms) and a knowledge hub, on the one hand to support the pilot regions but also to be applied by other regions across Europe. Moreover, an evaluation framework will be developed in order to evaluate the impact of TSLs in the TRANSFORMER pilot regions, as well as the respective tools and structures applied by the pilot regions. Project activities will be accompanied by comprehensive communicate and disseminate activities, providing (intermediate) results of the project and the activities in the pilot TSLs, providing a Hub with information, and offering training and capacity building activities for various target groups and stakeholders. Finally, an Exploitation Plan will be prepared for a long-lasting impact of the project.


**Keywords:** Transition Super-Labs, transformation, regions, governance, climate change, climate neutrality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Protocells in the Archaean Rock Record: Implications for the Origin of Life and Detection of Biosignatures' to be submitted under Horizon Europe.

assistant: **Abstract**

Fossilised remains of protocells transitioning towards the first living organisms may be observable in the early rock record distorting our interpretation of biosignatures. Protocells  cellular structures existing prior to the emergence of life  would have comprised simple membranes and molecular machinery. The formation of complex protocells is poorly understood. The interpretation of fossilised microorganisms in the early rock record is steeped in controversy. The potential for abiotic microstructures to further complicate this interpretation has long been recognised but has not been systematically tested. Evidence suggests that prebiotic structures are very difficult to distinguish from microfossils. However, little is known about the chemical and physical characteristics of these biomorphs that may enable us to tell the difference. This project will use a novel microfluidic approach to expand the experimental scope for formation of protocells of increasing complexity. Resulting microstructures will undergo silicification and diagenesis, the principal preservation pathway for early Archean microfossils. State-of-the-art analytical techniques will be used to characterise biomorphs, providing the first rigorous investigation of the feasibility of protocell preservation and how this might express in the geological record. These data combined with a predictive model and biological controls will allow for identification of key observables that will act as biogenicity indicators. Purported microfossils will then be examined and reinterpreted using the novel biosignatures. This project has the capacity to represent a paradigm shift in our fundamental understanding of the origin and evolution of life on Earth and possibly elsewhere in the Solar System. Collectively this will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Cell-type-specific modulation of protein homeostasis in health and disease'.

assistant: **Innovation**

The correct folding and assembly of proteins and protein complexes is essential to cellular function. Cells have evolved a network of proteins that detect and correct protein damage to maintain proteome health. However, many protein-misfolding diseases, including Huntington’s and Alzheimer’s diseases, are characterized by the accumulation of damaged proteins with devastating consequences for protein homeostasis (proteostasis), resulting in a collection of deleterious phenotypes and affecting many processes. Given that protein expression is cell-type specific, the proteins affected across different cell types are expected to vary. If this is in fact true, then the protein expression profile of a cell will have a profound impact on the folding capacity of its proteins in health and disease.The objective of this project is to determine how cellular proteostasis is adjusted in a cell-specific manner. To this end, I will combine several complementary approaches to compare proteostasis network interactions in different cell types of Caenorhabditis elegans. I will begin by using fluorescent sensors that enable a real-time assessment of proteostasis in a living organism to identify sensor interaction with the proteostasis network in muscle cells. I will then perform cross-tissue analyses of sensor interactions with the proteostasis networks in neuronal and intestinal cells. Finally, I will examine how the chronic expression of misfolded proteins influences sensor interactions with the proteostasis network. This approach will allow me to examine how protein interactions with the cellular proteostasis machinery are changed in response to an altered cellular environment and to determine how the resources of proteostasis are distributed in health and disease. I believe that the pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'De-vulcanisation of scrap car-tyres by way of micro-organisms' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Every year an enormous number of used car tyres is available. A number of these car tyres are put to use again. However, most of the tyres end up in controlled or uncontrolled waste. It is obvious what the consequences are for the environment. This project bears references to searching for a usable tecnique whereby used car tyres can by using micro organisms. The rubber powder, which is gained by applying this method, can be re used as raw material of the production of new rubber.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Supporting European policy makers: assembling information and briding models towards a European policy decision-support system' (TN) under Fifth Framework.

assistant: **Objectives**

The objective of spotlight is empowering European transport policy by providing them friendly and productive access to most advanced decision-making tools (strategic forecast and evaluation models). The expected achievement is a decision-support system (spotlight/dss) to build on top of existing knowledge (an interactive computer system that helps decision maker utilize data and models in making their decision). The odss is understood as the mechanism" to close the gap between forefront modelling research outcomes and policy makers.Therefore, the main planned activity is not the development of new databases or models, but "assembling" existing databases and "bringing" models into an organisational decision-support system (odss) useful for European policy-makers to manage the increasingly complex transport policy issues at European level."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The ‘Declining Significance of Gender’ Reexamined: Cross-Country Comparison of Individual and Structural Aspects of Gender Inequality' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The comparative research of long-term trends largely neglects structural mechanisms of gender inequality, i.e. the gender bias in which jobs and activities are evaluated and rewarded. I argue that as more women become integrated in positions of power, the stronger the role of structural elements is likely to become. However, because these are less visible and amenable to empirical assessment, they are under-researched compared to individual aspects, and are commonly assumed to be gender-neutral. The implication is that the importance of gender as a determinant of economic inequality in the labour market becomes insufficiently acknowledged, and thus difficult to track and eradicate.My empirical objective is to track structural vs. individual processes of gender inequality over a period of 40 years, using the case of occupations. My aim is to uncover the countervailing processes of women’s (individual) upward occupational mobility versus women’s (collective) effect on occupational pay. I argue that the effects of structural aspects of gender inequality increase over time, but are concealed by women’s (individual) upward mobility.I expect the dynamic of the two processes to vary between countries and also by class. I thus seek to examine the processes in four representative countries – Sweden, Germany, Spain and the United States – that differ in many of the institutional aspects that affect gender inequality, including the provision of welfare, gender ideology, wage structure, and political economy factors. Therefore, gender in/equality processes in these countries are expected to take different forms in both structural and individual appearances. That said, in all countries I expect gender equality processes to be more pronounced and rapid for advantaged women. At the st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a novel tandem ring closing metathesis process as a general route to the first syntheses of various lycorine type alkaloids' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Cancer is the leading cause of death worldwide and therefore a continued need exists for new drugs with new modes of action. To date, over 60% of drugs employed to target cancer are natural product derived or inspired and this places significant importance on research into the total synthesis of natural products. It also supports the need for the “next generation” of researchers to receive training in this area in order to enable the EU to remain globally competitive. The lycorine family of natural products have shown promise for the development of novel drugs; however a full study requires general access to these alkaloids. We propose a research project to develop methodology for the first syntheses of these complex natural products and novel derivatives, in order to enable future biological testing.For an efficient synthesis of these compounds, we envisage the development of a novel tandem RCM sequence, which can afford, in a single event, a decorated tetrahydroindole skeleton bearing an enol ether, which is crucial to the post-functionalisation of the bicycle. This methodology would allow a straightforward and selective synthesis of numerous lycorine alkaloids not synthesised to date. We also propose to explore the benefits of using Flow Chemistry, in particular to extend the methodology to more sensitive substrates. This is a rapidly expanding and exciting area of research, and dissemination of this knowledge within Europe in the near future is important. This proposal also offers the opportunity to establish future collaborations in this area, strengthening EU competitiveness.The applicant is an outstanding British female scientist and this fellowship would facilitate her pursuit of an independent academic career within the EU and her ability to become a future rol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dissecting Carotenoid-Related Protein Interaction Dynamics for Tailoring Healthier Crops' under Seventh Framework.

assistant: **Concept**

Improving health, food quality and food safety are major demands of Europe’s society and economy. Addressing these demands requires a deeper knowledge of the basic mechanisms that regulate plant and animal metabolism. Carotenoids are a group of plant pigments that animals need to ingest as an essential source of retinoids (including vitamin A). Dietary consumption of carotenoids is also associated with protection against a broad range of chronic human diseases.Despite carotenoids are essential for plants and animals we still lack fundamental knowledge about how carotenoid biosynthesis is regulated. Particularly, our comprehension of how interactions at the protein level modulate carotenoid metabolism is still scarce. Tomato (Solanum lycopersicum) fruit ripening represents a well-characterized model to study carotenoid biosynthesis and assaying metabolic remodeling strategies endeavored to improve the health-promoting properties of crops. This proposal aims to discover and validate protein factors interacting with known regulatory components of the carotenoid pathway in tomato fruit, to provide an initial understanding of how their dynamic interactions orchestrate carotenogenesis during tomato fruit ripening. It is expected that the proposed study will lead to the generation of fundamental knowledge about carotenoid regulatory networks with a potential application in breeding programs.Both the project and the host institution aim to unite the highest excellence in basic scientific research with applied technological innovation to meet the current demands of European society. The strong biotechnology background of the applicant together with the highly developed expertise in carotenoid research of the receiving group will synergistically contribute to the success of this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel Polymeric Inhibitors of Bcl-2 protein A New Class of Therapeutics for the treatment of Cancer' in the context of a Sixth Framework call.

assistant: **Objectives**

This proposal is focused on More Efficient Cancer Therapies, topic of fundamental importance in the European Research Area and with high social impact worldwide. The Primary Scientific Aim of this proposal is to develop an efficient method for selective tumour delivery and cellular internalisation of therapeutic agents capable to modulate the activity of Bcl-2 proteins inducing apoptosis of tumour cells. This involves tackle an intracellular delivery problem of global importance in cancer therapy, which can be addressed by conjugation of the therapeutic agent through a rationally designed biodegradable linker either to a Trojan peptide" or to a water-soluble polymeric carrier, working in this case within the novel area of Polymer Therapeutics. This research topic falls completely into the interface of polymer chemistry and the biomedical sciences and will hopefully give rise in the 21st century to a second generation of anticancer therapies with improved characteristics, higher tumour selectivity, higher efficiency and reduced systemic side effects. Polymer Therapeutics is a new area of research in the host institution, the CSAT at Valencia, applicant's region of origin, and almost unknown in Spain. Therefore, development of this proposal offers a highly innovative research approach, increasing the attractiveness and competitiveness of the host institution and Spain, contributing in this way to the European research excellence. The CSAT is born devoted to reach the highest standards in basic research and to explore its putative industrial applications in order to improve the quality of life and health of the community. Its aims together with the advanced multidisciplinary training offered by the host institution not only will reinforced the applicant's scientific knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An industry system enabling the use of a patented materials processing technology for Low Cost forming of Lightweight structures for transportation industries' (LOCOLITE) targeting Seventh Framework.

assistant: **Abstract**

Environmental wellbeing backed by increasingly severe legislation dictates that pollution and energy consumption by automobiles must be reduced significantly. The outcomes of this project will enable both these imperatives to be achieved simultaneously.  The project aim is to establish production lines in Europe that manufacture components for lightweight complex-shaped automobile body structures that are significantly lighter and of comparable strength and stiffness to those currently available.This will be achieved by exploiting a new patented thermo-mechanical processing technology (HFQ) for sheet aluminium alloy that enables, for the first time, parts in heat treatable alloys to be produced to net-shape with maximum attainable mechanical properties. The life-cycle energy consumption of automobiles will be reduced; in the production stage, by the low energy requirements of HFQ, which is enhanced by the potential use of low cost recycled raw material and in the driving stage, by the reduced fuel consumption associated with lightweight vehicles. Reduced pollution is a natural corollary of low energy consumption.Exploitation of this groundbreaking technology will be achieved through refinement of its laboratory scale development by university, research institution and manufacturing SME collaboration, leading to production lines being established in Tier 1 companies. Two such lines are anticipated as an outcome of the project. In 8 year period, over 30 production lines will be established in Europe and over 1000 jobs could be created. It is expected that new Al-alloy body and chassis structures will be produced in a mass-production scale, with weight saving of over 40% for the Classes C&D and above segment vehicles (which are currently made of steel). Thus, 60% of cars c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Symmetries in Geometric Analysis' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The main objective is to organize a conference Symmetries in Geometric Analysis" to be held in the Stefan Banach International Mathematical Center in Warsaw, Poland. The conference will be devoted to a subject, which is now very active and has parts in common with Complex Analysis, PDE (geometrical theory), Differential Geometry, Algebraic Geometry, and Mathematical Physics. The primary topics covered during the conference will include: Parabolic geometry, Cauchy-Riemann (CR) geometry, normal forms of CR manifolds, Bergman kernels of domains, conformal differential geometry, integral geometry, singularities of complex gauge fields, mirror symmetry, Seiberg-Witten-Floer homology, Nahm'S equations. Symmetry is a background principle, which is observable in many areas of mathematics and physics.Many striking results are obtained at the border-line between different fields of geometry, analysis and mathematical physics. The recent development in so-called parabolic geometry particularly led to a better understanding of CR-geometry (important in complex analysis) and conformal geometry (important in physics). For further progress in this field it will be extremely useful to bring together specialists from geometry, complex analysis and physics. Already many top specialists in the above mentioned fields have agreed to participate.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00188-1.pdf"