RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biomarkers of Risk-taking and Anxiety in Adolescents: an inVestigation on the Effects of stress' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Adolescence is a pivotal developmental window characterised by profound neurobiological, social, and emotional changes. It is also the peak period for the onset of anxiety disorders, which affect 1 in 7 individuals across the lifespan and rank among the top global contributors to disease burden. Paradoxically, while anxiety in adults is typically associated with avoidance, many anxious adolescents engage in impulsive and high-risk behaviours. This clinical and conceptual paradox remains poorly understood. This Action will address this gap by adopting an integrated biopsychosocial approach to investigate how anxiety and stress jointly influence the anticipatory, choice, and feedback phases of risk-related decision-making in adolescence. Leveraging cutting-edge methods, including behavioural paradigms, functional near-infrared spectroscopy (fNIRS), autonomic psychophysiology (HRV, skin conductance), actigraphy, and ecological momentary assessment (EMA), I will bridge lab-based precision with ecological validity. I hypothesise that stress dynamically shifts neural and autonomic responses in anxious adolescents, producing divergent outcomes: maladaptive avoidance or excessive risk-taking. Individual differences, such as environmental sensitivity and physiological self-regulation, are expected to moderate these effects. The findings will produce early, scalable markers of maladaptive trajectories, informing targeted prevention. Through a unique combination of expertise and training opportunities offered during the outgoing (University of Connecticut) and return (University of Padua) phases, this fellowship will provide me with advanced interdisciplinary skills, expand my methodological repertoire, and consolidate my path towards independence as a leading researcher in develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fashion On-Line for SMEs (Virtual Shops for Fashion SMEs-Benchmarking and Best Practice Pilots)' under Fifth Framework.

assistant: **Concept**

FASHION ON-LINE aims at demonstrating by systematic benchmarking and the deployment of selected pilots the efficiency of innovative technologies in overcoming the main obstacles to broad adoption of B2C e-commerce by fashion SME retailers, their business partners and consumers, namely the size & fit problem (related to customers body size and shape) and the product description problem(fabric colour, garment style).Ten pilots will be deployed in Spain, Italy, Portugal & Greece, implementing novel Internet technologies for clothing products description. Representatives of Regional Authorities from regions with pronounced presence of Textile-Clothing SMEs will monitor the progress of the project, either directly (as members), or through their contacts with the regional Associations.Objectives:The main project technological objectives are:a) To benchmark emerging technologies enabling size identification from body measurements, simple Virtual try-on accurate & appealing e-catalogues of clothing items, accurate on-line colour reproduction;b) To deploy 10 pilots in Spain, Italy, Portugal & Greece, implementing novel Internet technologies for clothing products description;c) To develop a portal, supporting & encouraging SMEs to adopt B2C e-commerce featuring a Generic fashion site demonstrator, comprehensive implementation information & guidelines, links to technology providers & benchmarking results (links to Technical Centres), continuous technology updates & on-line Consultancy facilities. Regional Authorities Representatives from regions with pronounced presence of Textile-Clothing SMEs will monitor project progress.Work description:The project workplan is organised so as to serve three main goals:- to establish a systematic technology and business oriented approach to ben
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Random Matrices, Random Graphs and Circular Elements' (RanMatRanGraCircEl) targeting Horizon 2020.

assistant: **Abstract**

Random matrix statistics are a paradigm for the collective behaviour of many strongly correlated random variables. The proposed projects will fundamentally advance our knowledge about random matrices in novel directions.   We study spectral properties of random matrices when the matrix size becomes large. More specifically, we establish the universality of the fluctuations of the smallest singular value of almost square random matrices with independent entries. Moreover, we determine the asymptotic eigenvalue density of non-normal random matrices with correlated entries of general expectation and the Brown measure of operator-valued circular elements. We also obtain a central limit theorem for the difference of the linear statistics of a matrix with independent, identically distributed entries and its minor. Furthermore, we analyse the spectra of random graphs. Specifically, a transition in the eigenvalue fluctuations of very sparse Erdos-Renyi graphs, the eigenvector delocalisation of directed Erdos-Renyi graphs as well as the extreme eigenvalues and eigenvectors of preferential attachment graphs. Finally, we investigate a variational problem motivated by wireless communication.   The techniques proposed for these projects comprise a variety of tools from analysis (spectral theory, variational methods), probability theory (stochastic differential equations, large deviation bounds) and mathematical physics (self-consistent equations). For the purpose of these projects, the tools mentioned above will be developed further.


**Keywords:** Eigenvalue, Eigenvectors, Universal fluctuations, Erdös-Rényi graphs, non-Hermitian random matrix
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Proving causality of liquid-liquid phase separation for the acquisition of nuclear-like functions by Giant Viruses Viral Factories' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Giant Viruses (GVs) encode thousands of ORFan genes but their study has been nearly impossible due to the lack of genetic tools for reverse genetics. The aims of ViDaMa and the tools I designed will shed light into this Viral protein Dark Matter. Particularly, I will study how new genes from Mimivirus were engineered during evolution to acquire nuclear-like function for their Viral Factories (VFs). VFs physically separate viral DNA replication and transcription from translation and likely segregate DNA into active and silent. How these functions are accomplished remains elusive.I will demonstrate causality of liquid-liquid phase separation (LLPS) for the acquisition of nuclear-like functions of the Viral Factories (VFs) of Mimivirus. To do so, I will:1)  Generate genome-wide loss-of-function screens for the identification of gene function and proteome-wide localization of virtually all Mimivirus and its host Acanthamoeba proteins.2) Combine biochemistry and cell biology to dissect the nature, functions and components of the VFs of Mimivirus. 3) Strip down VFs to their minimal components in order to utilize them to improve production efficiency and purity of mRNA during in vitro transcription.  ViDaMA will empower the GVs scientific community with genome-wide and proteome-wide data of gene function and protein localization. It will transform the field from mostly descriptive to allow the dissection of the molecular mechanisms behind viral phenotypes. ViDaMa will also address the molecular mechanisms that allow the VFs to acquire nuclear-like functions, directly tackling the viral eukaryogenesis theory. The new classification of VFs as membrane-less organelles and the study of the molecular mechanism behind their biogenesis and functions will shed light into general mecha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Metabolic control of cell growth by mTOR in health and disease: a multi-disciplinary training'.

assistant: **Innovation**

MENTOR is a multi-disciplinary training network which focuses on the mTOR pathway, a central mechanistic hub that integrates nutritional cues and controls cell growth and metabolism. Aberrant activation of mTOR underlies monogenic diseases with broad spectrum of pathological manifestations, including tissue overgrowth, polycystic kidneys and neuropsychiatric disorders affecting around two million of people worldwide. To avoid the medical errancy of patients in different clinical departments and surgical mutilations, approaches of personalized medicine depending on the genetic landscape need to be implemented, taking advantage of suitable pharmacological products. The overall goal of the MENTOR research program is to: delineate molecular mechanisms of fundamental and aberrant mTOR functions, preclinically decipher the pathophysiology of mTOR, develop a novel arsenal of drugs to selectively target the pathway and provide proof-of-concept support for such interventions. This ambition can only be achieved by the multidisciplinary research program that MENTOR has conceived, through the training of a new generation of scientists at Graduate Schools of biology, pharmacy, chemistry or medicine that will become the leaders of mTOR research in both public and private sectors. MENTOR will establish a collaborative and efficient network from academia to industry, involving patient associations and clinicians with impact on scientific community and society.


**Keywords:** Multidisciplinary, Growth, Genetics, mTOR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Clinical and pre-clinical evaluation of fosmidomycin and its derivates as antimalarial drugs' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The present project will help to develop fosmidomycin, an inhibitor of the DOXP reductoisomerase, into an antimalarial drug. In parallel to the clinical evaluation of fosmidomycin in human volunteers, tests with derivatives of fosmidomycin with demonstrably improved pharmacological profiles in two different non-human primate models will be the pre-requisite for a straight forward clinical development of a second generation of DOXP reductoisomerase inhibitors as antimalarial drugs. Furthermore, biochemical, molecular biological and pharmacological studies will increase our knowledge about the relevance of the DOXP pathway for the survival of malaria parasites, and demonstrate its potential as a new target for chemotherapy. Finally, new DOXP reductoisomerase inhibitors with improved antimalarial activity will be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Sequencing DNA molecules from mechanical opening experiments: bounds from information theory and inference algorithms'.

assistant: **Objectives**

The DNA molecule encodes the genetic information; reading the sequence it carries is of great relevance for biology and medicine. Currently available techniques are able to sequence DNA with high reliability but are very expensive in terms of time and human resources. We will focus on a new method for sequencing that is under intensive experimental investigation. The double helix of the DNA molecule is opened through a mechanical separation of the two strands, and the required force is measured. From the force signal one would like to reconstruct the DNA sequence.The method is fast, but the force signal is very noisy and the reconstruction of the sequence turns out to be a difficult inference problem. A detailed comprehension of the noise and the design of optimal algorithms for data analysis are mandatory to achieve a reliable sequencing. The project will focus on the theoretical aspects of the method.We will:1) investigate the different sources of noise in the context of recent models for the DNA opening;2) try to obtain theoretical bounds on the amount of information that can be obtained from the mechanical opening experiment as a function of the experimental parameters (resolution, total duration of the experiment, ...);3) design efficient algorithms to optimise the data analysis in order to get as close as possible to the theoretical bounds;4) test the algorithms against experimental data on known sequences and attempt to predict unknown sequences.The project, if successful, will clearly establish the intrinsic limits of the method, in terms of information theory. Our results will be validated through a close collaboration with a leading experimental group in the field and, hopefully, will allow for a reliable mechanical sequencing in a not too far future. We belie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Electronic Transport and Spin dynamics through SiGe self-assembled quantum dots' (SPIDERMAN).

assistant: **Innovation**

In 1990 Eaglesham and Cerullo [Phys. Rev. Lett. 64, 1943 (1990)] reported for the first time that three dimensional SiGe islands can be grown crystalline on Si, creating thus high expectations that these nanostructures could provide a valid route towards innovative, scalable and CMOS-compatible nanodevices. Two decades later the researcher has investigated for the first time their electronic properties by fabricating three terminal devices after integrating them on silicon on insulator substrates. The first results obtained so far indicate that SiGe self-assembled quantum dots have a rather unique combination of properties, i.e. low hyperfine interaction and strong spin-orbit coupling. The aim of this project is to study the potential of SiGe self assembled quantum dots for novel nanoscale devices including operation at room temperature. The objective of the present proposal is above all to: a) study spin-dependent transport in self assembled QD aiming to identify signature of spin precession induced by the spin orbit coupling b) study the characteristic time scales for spin dynamics in the SiGe QD system and move towards fully electrical coherent spin manipulation and c) realize a high performance p-type nanoscale transistor operating at room temperature. The experimental research proposed here may provide a new handle on the physics and control of electronic spins in silicon-based nanostructures with possible relevant implications for spintronics and spin-based quantum computation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cytosine-5 methylated RNAs as stem cell regulators in normal tissues and diseases' (2007-2013).

assistant: **Concept**

Stem cells differentiate into all mammalian tissues and organs during development, and remain present to maintain and replenish tissues throughout life.  Stem cells continuously maintain their population (self-renewal) while generating progeny (differentiation). During self-renewal stem cells have to avoid cell cycle exit and differentiation; whereas during differentiation stem cells must evade uncontrolled proliferation. Dissecting the regulatory pathways controlling the balance between these two states is fundamental to understanding how stem cell mis-regulation causes human diseases.  Although transcriptional regulation of stem cells is increasingly understood, virtually nothing is known about how post-transcriptional mechanisms can influence stem cell maintenance.Post-transcriptional modifications are commonly found in non-coding RNA species, yet the biological function is unknown. My previous studies identified cytosine-5 methylation (m5C) of RNA as a novel mechanism regulating stem cell fate. m5C is a widespread modification in both DNA and RNAs and their methyltransferases share many structural features. Whereas the functions of m5C in DNA have been extensively studied, the cellular and molecular functions of the same modified nucleobase in RNA remain unclear. Using a combination of system-wide approaches, mouse models and in vitro differentiation assays, we propose to (1) globally identify m5C in RNA species; (2) functionally analyze the roles of methylated versus non-methylated RNAs in stem cells; and (3) determine how aberrant m5C modifications can cause intellectual disability disorders in humans. Our comprehensive approach will answer how post-transcriptional modification control stem cell fate in normal tissues and might lead to the discovery of novel thera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Branching ratios of electron-ion recombination reactions of astrophysical interest' (1998-2002).

assistant: **Innovation**

Electron-ion recombination reactions are particularly important in laser plasmas, combustion flames and the interstellar medium (ISM). The research project focuses on assessing the branching ratios of the astrophysically interesting electron recombination processes of HCO^+, HN_2^+, HCO_2^+, HCCCN^+ , C_2H_4^+, CH_3CCH^+ , C_3H_3^+(propargylium and cyclopropenium isomers) and HCCCCH^+. Whereas reaction rates of some of these processes are well known, little information is available about their ranching ratios, which are crucial for model calculations of interstellar clouds and planetary ionospheres. The CRYRING storage ring located in the Manne Siegbahn Laboratory at Stockholm University, Sweden is one of only two facilities world-wide capable of performing the proposed experiments. It allows to perform experiments at the very low collision energies encountered in dark interstellar clouds. The ions, generated in a plasma discharge source are stored in the ring and merged with the electrons. The neutral recombination products will be detected with a surface barrier detector and the transmission grid method will be used to assess the branching ratios. If successful, the proposed research will mean a great step forward in understanding of interstellar and ionospheric recombination reactions and yield reliable data that will considerably improve the quality of astrophysical model calculations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Amyotrophic Lateral Sclerosis from a cortical perspective: towards alternative therapeutic strategies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Amyotrophic Lateral Sclerosis (ALS) is the most common adult-onset neurodegenerative disease of the motor system, with a prevalence of 2-3/100 000. In spite of intensive research efforts, ALS remains an incurable disease and presents with a very severe prognosis, leading to patient death within 2 to 5 years following diagnosis.At the cellular level, ALS is characterized by the combined degeneration of both upper motor neurons (UMN, or corticospinal motor neurons) whose cell bodies are located in the cerebral cortex, and that extend axons to the medulla and spinal cord, and lower motor neurons (LMN, or spinal motor neurons) whose cell bodies are located in the medulla and spinal cord, and that connect to the skeletal muscles. This dual impairment allows to discriminate ALS from other, less severe diseases affecting either UMN or LMN. Despite this precise clinical description, it is striking to note that preclinical studies have so far mostly concentrated on LMN, leaving aside the role of UMN in ALS. This project aims at shedding light on the contribution of the dysfunction and/or the loss of UMN in ALS, in order to design and test new therapeutic strategies based on the protection and/or the replacement of this exact neuronal type. This innovative question has never been directly asked so far. Our working hypothesis is that specific neurodegeneration of UMN, in the course of ALS, does not represent an isolated side effect, but rather actively contributes to the onset and progression of the disease. Based on the discovery of new molecular players, and the development of alternative therapies, this original thematic has the ambition to provide clinicians and patients with new answers and new therapeutic assets.