RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Subaltern Workers, Labour Relations, and Empire Building in the Portuguese Estado da Índia (1510-1663)' under Horizon Europe.

assistant: **Concept**

How and to what extent did 'free' and unfree non-European labour contributed to build and sustain the Portuguese Asian empire during the 16th and 17th centuries? This is the main question I will address in this project, by exploring the case study of the Estado da ndia (henceforth EI) between 1510 and 1663. The main hypothesis I want to test is that the EI was able to develop and sustain itself (even in times of decline) due to a highly intensive extraction and allocation of non-European labour, especially when compared with other European counterparts in the Indian Ocean, namely the Dutch and the English. This project dialogues therefore with a wider trend in the historiography that analyses the importance of the populations under European imperial dominion for empire building and economic development, especially in what concerns non-European capital, natural resources, and labour. The allocation of labour in colonial settings was noticeable in many dimensions of the everyday life. This project will focus on three intertwined locus of observation: the military, the urban and the rural labour markets. By gathering evidence from European and Asian archives, building and testing a dataset on occupational structures and labour relations in the Portuguese EI, EMPIRELAB will offer a first insight in labour dynamics in Portuguese Asia. The findings of EMPIRELAB will provide historians of the European and non-European empires with comparative data and an innovative perspectivein order to feed larger debates both in academic and non-academic contexts regarding the impact of colonialism in our societies. It will raise awareness about labour and migration in historical perspective, thus helping to overcome established preconceptions about the relevance of labour for imperial hist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EFFECT OF IL-23 ON IMMUNE CELL INFILTRATION AND TUMOR GROWTH IN A GLIOMA MODEL' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Malignant gliomas are the most common primary central nervous system (CNS) tumors in humans and belong to the most aggressive types of cancer. Glioblastoma cells display an invasive phenotype and release immunosuppressive molecules to avoid the host’s immune response. Therefore, there is an urgent need for novel tumor-selective treatments that specifically target migratory glioma cells and/or promote inflammatory anti-tumor responses.The possibility of using immuno-therapy to control tumor growth is currently being investigated. Considering the CNS, this approach acquires unique characteristics due mainly to the existence of the blood brain barrier. In this regard, the IL-12/IL-23 superfamily of cytokines represents a promising immuno-therapy tool. Despite their structural similarities, they play different roles in the immune response promoting Th1 or Th17 polarization, respectively. Moreover, IL-23 but not IL-12 has been described as essential for the infiltration of CD4+ cells into the CNS in experimental autoimmune encephalomyelitis (EAE). Considering tumor growth, the anti-tumoral effects of IL-12 have been described in several models including glioma. However, in the case of IL-23 both tumor-promoting and tumor-suppressive effects have been reported, depending if endogenous or exogenous IL-23 is examined. Regarding glioma models, no data is available on how endogenous IL-23 may modulate tumor growth.The goal of this project is to evaluate the differences of endogenous and exogenous IL-23 effect on a glioma model. Moreover, the possible modulation exerted by IL-23 on immune cell infiltration into the CNS in a glioma context will be studied. To achieve these objectives, novel multimodal non-invasive molecular imaging techniques will be used, providing not only spatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Constraints on the extent and timing of glaciations, and tectonics, in South Central Tibet, using cosmogenic radionuclide dating methods'.

assistant: **Concept**

The extent and timing of glaciations in the interior of the Tibetan Plateau provides important information about recent climate changes in this area, and offset glacial deposits place important constraints on tectonic rates along strike-slip and normal faults in the Plateau.In particular, the reconstruction and dating of the former extent of glaciers is essential for paleoclimatic modeling that are used to predict future climate change. In addition, glacial deposits have been used to constrain tectonic off sets, and by assigning ages to these features, slip rates are inferred.Importantly, these slip rates have been used to test different models of how continent-continent convergence is accommodated along the Indo-Eurasian plate boundary in central Asia. The Nyainqentanghula and Ama Zhuma Ranges provide an excellent opportunity to constrain the timing of glaciations in south central Tibet.Radiocarbon dating is difficult or impossible because of the lack of organic material in these regions thus, the accumulation of 10Be and 26Al cosmogenic radionuclides may be used to constrain the timing of moraines emplacement.We will focus on timescales ranging from present up to 300000 years. Determining the spatial and temporal extent of Late-Quaternary glaciations in Southern Tibet is timely for several reasons.First, the results of this study will add new data on climatic events in Tibet, which is still poorly known. Second, the timing of glaciations in Southern Tibet may be used to reaffirm or revise tectonic slip rates along faults that cut glacial deposits in these areas.Thus, this project will provide important information to inform both climatic and tectonic models of this region.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dynamic and Plasticity of Spatial Perception and Attention Neural Processes' (DYNPSPANP).

assistant: **Innovation**

Spatial attention is vital for interacting with the surrounding environment. Recent studies in cognitive neuroscience suggest that the fronto-parietal regions may exert a top-down attentional influence on early sensory processing areas. However the dynamics and the role of these cortical interactions remain poorly understood. Furthermore, spatial perception was shown to be modulated by subtle knowledge about our previous, on-going and up-coming action. The current project aims to provide direct evidence for the causal influences of the fronto-parietal cortex on primary and secondary visual areas (such as visual areas V1-V4) and to show their role in action-based modulation of spatial perception. Notably, it will address whether and how these top-down neural processes may contribute to flexibly modulate space perception e.g., by biasing sensory processing toward specific locations in space. To specifically test for causality, Transcranial Magnetic Stimulation (TMS) will be combined with concurrent Electroencephalography (EEG) in order to modify neural activity through stimulation over a precise region of the fronto-parietal cortex while recording with high temporal resolution the different stages of the cortical response to TMS over the whole cortex, in particular in the posterior occipital (visual) areas. The outgoing phase of the project aims to establish the cortical reactivity and functional connectivity of the fronto-parietal network, and to show its role in action-induced perceptive plasticity. During the return phase, the applicant will exploit her abilities on EEG/TMS co-registration to study the neural functional plasticity of the above described network induced by subtle features of our previous sensori-motor experience. EEG/TMS co-registration will be achieved
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reflecting Knowledge Diversity' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The Web has proved to be an unprecedented success for facilitating the publication, use and exchange of information, at planetary scale, on virtually every topic, and representing an amazing diversity of opinions, viewpoints, mind sets and backgrounds.  Its design principles and core technological components have lead to an unprecedented growth and mass collaboration. This trend is also finding increasing adoption in business environments. Nevertheless, the Web is also confronted with fundamental challenges with respect to the purposeful access, processing and management of these sheer amounts of information, whilst remaining true to its principles, and leveraging the diversity inherently unfolding through world wide scale collaboration.RENDER will engage with these challenges by developing methods, techniques, software and data sets that will leverage diversity as a crucial source of innovation and creativity, whilst providing enhanced support for feasibly managing data at very large scale, and for designing novel algorithms that reflect diversity in the ways information is selected, ranked, aggregated, presented and used.  RENDER's information management solution will scale to very large amounts of data and hundreds of thousands of users, but also to a plurality of points of views and opinions.  This will be demonstrated through the usage of realistic data sources with billions of items; through open source extensions to popular communication and collaboration platforms (MediaWiki, WordPress); and through three high-profile case studies.RENDER will help to realize a world where information is acquired and shared in a fundamentally different manner than the consensual approach promoted by movements such as Web 2.0, and where communication and collaboration across the b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Evolving Attitudes toward Single Motherhood in the UK and Russia'.

assistant: **Objectives**

Single motherhood has become a widespread phenomenon within contemporary societies, part of an ongoing revolution in family life. In order to address the outdated and thoughtless language being used to describe single mothers and their children, I will scrutinize the emergence and development of 21st century European cultural attitudes toward single motherhood using desk-based methods. To reconstruct its evolvement since the beginning of the century, this study proposes an innovative multidisciplinary approach, which combines comparative analysis of the UK’s and Russia’s policies toward single mothers with content and multiple approaches to text analysis of non-fiction, children’s and young adult fiction, social semiotics and multimodal discourse analysis of children’s illustrated literature. The overall aim of the proposed research is to advance my career through the completion of the present project, which examines the development and current stage of the cultural attitudes and policies directed toward single motherhood in two politically different countries. This aim is reflected through three primary objectives: to investigate contemporary European policy on single motherhood with focus on the UK and Russia, with attention to public attitudes toward the variation (unwed mothers, widows, divorced mothers, single mothers by choice) within single mothers as a social group;  to examine the gendered British and Russian cultural ideologies since the beginning of the century up to the present and expressed through non-fiction and children’s and young adult literature and centered around social and cultural facets: abortion, virginity, affairs with men, pedagogical strategies, bad habits, beauty and clothes, professional career and education, and (re)marriage; to examine ho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Benchmark models for the water framefork directive' (BMW) targeting Fifth Framework.

assistant: **Abstract**

EU Water Framework Directive (WFD) mandates Member States to develop river basin management plans for each river basin district. To achieve this the responsible authorities must have tools to assess alternative management options. The objective of this proposal is to establish a set of criteria to assess the appropriateness of integrated models for the use in the implementation of WFD. The project aims at testing and demonstrating the use of integrated models applied to selected intensively studied river basins, to answer questions relevant for the implementation of the WFD. The active participation of the end-users will ensure that the criteria and models are operational and functional at the management level. An interactive internet-based Toolbox will be built to disseminate information concerning integrated models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'DEVELOPMENT OF A MULTIMEDIA DATABASE PROVIDING INFORMATION ON THE ACCESSIBILITY IN PUBLIC BUILDINGS FOR PEOPLE WITH HANDICAPS TO THEIR MOBILITY'.

assistant: **Innovation**

For disabled or elderly people, public facilities are often inaccessible because of physical barriers to mobility. Information on access is a great step towards independence, yet is rarely available, particularly for business and private travel abroad. This project will produce a marketable database with information on barriers to mobility in European cities and local districts, on the basis of transnational standards, made available through CD-ROMs and on-line services. It will comprise a BIS model town guide - a transnational concept called Town-guides for the handicapped; a data-collection tool for producing these following the model town guide; and a multimedia database giving information on accessibility of public buildings to people with mobility handicaps.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Small molecule regulators of promoter quadruplexes' (SMRPQ), addressing dissemination and exploitation.

assistant: **Impact**

Guanine-rich DNA sequences can adopt stable non-classical four-stranded guanine quadruplex structures in-vitro under near physiological conditions. It has been shown that a ligand stabilizing such quadruplex could inhibit the extension of telomeric DNA by the human telomerase. Therefore, ligands stabilizing and/or inducing the formation of human telomeric quadruplex have potential as anti-cancer therapeutic agents. Since quadruplex structures differ considerably from double-stranded B-DNA helices, there has been considerable interest in the design and development of ligands that selectively stabilize G-quadruplex over duplex DNA.Further, sequences in the promoter region of certain oncogenes can potentially form quadruplex structures and it is believed that such structures can interfere with the expression level of these genes. However, it also raises the important need to ultimately generate ligands that show discrimination not only between quadruplex and duplex DNA but also between quadruplexes themselves. We propose here the design and synthesis of several heterocycle-based planar macrocycles where heterocycles (e.g. pyridine, oxazole and thiazole) are either directly linked through C-C bond or through amides. Such structures are inspired from the natural p roduct telomestatin, a flat poly-oxazole macrocycle, which is the most potent telomerase inhibitors identified so far.Those planar macrocycles should offer the advantage of better solubility when compared to telomestatin and represent an original platform for appending side-chains capable of interacting with specific loops and grooves of a particular quadruplex. These new ligands will then be screened against three biologically relevant quadruplexes located within the promoter regions of oncogenes c-kit, N-ras and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hydraulic compression for high capacity hydrogen refuelling station Demonstration' (H2REF-DEMO) targeting Horizon Europe.

assistant: **Abstract**

H2REF-DEMO aims to further develop and scale up by a factor of 5 the innovative compression concept developed in H2REF, in order to address large vehicle refuelling applications requiring hydrogen to be dispensed at rates of hundreds of kg/h, such as bus fleet refuelling every evening at the bus depot, truck refuelling, and train refuelling. Thanks to demonstrating the process during one year for commercial 35 MPa refuelling of trucks, the project will bring to TRL7 the disruptive compression technology previously developed in the H2REF project and already validated for 70 MPa refuelling of light duty vehicles.Along with capacity scale-up, H2REF DEMO will focus on process optimisation, cost reduction and further durability testing, Full optimisation will be achieved by first developing a digital twin of the scaled-up process. Use of accumulators with shells in hoop wrapped steel (Type II), a suitable technology for 35 MPa refuelling, will allow to optimise costs. A thorough accelerated testing approach involving at least 500 hours of continuous operation, will allow to verify durability of the accumulators and the compression stages over the full range of operating conditions. The demonstrated system is expected to provide a peak dispensing capacity of 150 kg/h, amounting to 1200 kg/d with 8 hours of daily operation, with a targeted cost of 1200 €/(kg/d).  The process is expected to reduce electricity consumption to 3.5 kWh/kg of dispensed hydrogen, from production on site at 2 MPa to vehicle tank at 42 MPa. The knowledge gained will allow subsequent development to focus on commercial product development for short term commercial deployment. A multi-disciplinary team, composed of 4 industrial companies and 3 RTOs, combining expertise in hydraulic power supply, in bladde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Biophysical networks underlying the robustness of neuronal excitability'.

assistant: **Concept**

The mammalian nervous system is in some respect surprisingly robust to perturbations, as suggested by the virtually complete recovery of brain function after strokes or the pre-clinical asymptomatic phase of Parkinson’s disease. Ultimately though, cognitive and behavioral robustness relies on the ability of single neurons to cope with perturbations, and in particular to maintain a constant and reliable transfer of information.So far, the main facet of robustness that has been studied at the neuronal level is homeostatic plasticity of electrical activity, which refers to the ability of neurons to stabilize their activity level in response to external perturbations. But neurons are also able to maintain their function when one of the major ion channels underlying their activity is deleted or mutated: the number of ion channel subtypes expressed by most excitable cells by far exceeds the minimal number of components necessary to achieve function, offering great potential for compensation when one of the channel’s function is altered. How ion channels are dynamically co-regulated to maintain the appropriate pattern of activity has yet to be determined.In the current project, we will develop a systems-level approach to robustness of neuronal activity based on the combination of electrophysiology, microfluidic single-cell qPCR and computational modeling. We propose to i) characterize the electrical phenotype of dopaminergic neurons following different types of perturbations (ion channel KO, chronic pharmacological treatment), ii) measure the quantitatives changes in ion channel transcriptome (40 voltage-dependent ion channels) associated with these perturbations and iii) determine the mathematical relationships between quantitative changes in ion channel expression and electr