RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Road to Friday of Science 3.0'.

assistant: **Concept**

ReFocuS 3.0 (Road to Friday of Science Third edition) project aims to substantially raise public awareness about importance and positive role of science for and in the society by bringing the researchers into the focus of the general public. This year, by using open to diversity as an overall theme, we will present the openness of science, sharing of knowledge and the concept “science is everywhere”. Within this concept, we will show the new dimensions in perceiving researchers and their role in society, increase public awareness on the positive role of research in and for the society and promote the involvement of citizens in science. The science is not only confined to labs, but it also permeates the things surrounding us, and most importantly science is open to diversity. We want to make people aware that everybody can contribute to science. This future direction of the science, open science, cannot be achieved without combining and involving not just several academic disciplines, but also non-academia. The project relies on diversity of all actors in the science networks: researchers of diverse backgrounds and areas of expertise, citizens as a new type of researchers, diverse research topics important for the society and diverse institutions involved in science. The activities will take place in the thus far biggest ReFocuS edition, involving 14 cities and 46 diverse venues, including research institutes, old streets and houses, museums, archaeological sites, fortress, science clubs, shopping malls, city parks and libraries. The true value is reflected in presenting the openness of science to diverse contributors, both people and institutions. The fact is that both science and society can benefit from diversity since diversity delivers different perspectives on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Shared Responsibility in International Law' (SHARES) targeting Seventh Framework.

assistant: **Abstract**

SHARES seeks to rethink the allocation of international responsibilities in cases where actors cooperate to pursue common international objectives, for example environmental protection and protection of human populations from mass atrocities. International cooperation may complicate attempts to determine who is responsible for what. SHARES is based on the unrecognized and unexplored fact that as the responsibility for policies is shared among more actors, the discrete responsibility of every individual actor is diminished proportionately. International cooperation paradoxically may undermine the key objectives of any scheme of responsibility : the protection of the international rule of law and the provision of remedies of injured parties. The dominant principle of individual responsibility, and the scholarship based on it, provides us neither with the concepts nor the perspectives for addressing shared responsibilities. SHARES will uncover the extent and nature of the problem of scattering of international responsibilities in cases of international cooperation and will provide fresh perspectives on how cooperation can be better matched by a corresponding system of international responsibility. It will pursue two interlocking tracks, focussing on principles and processes of international responsibility. As to principles, it will examine the possibility of holding multiple actors collectively, jointly or proportionately responsible. As to processes, SHARES will rethink how (quasi-)judicial processes may better taken into account the collective context of the international policies of states and other actors. SHARES will complement a conceptual and theoretical foundation with a thorough empirical approach, exploring through case-studies how we can improve our understandin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Gatekeepers to International Refugee Law? – The Role of Courts in Shaping Access to Asylum' (ACCESS) under Horizon Europe.

assistant: **Objectives**

Pushbacks, walls, fences, detention measures and externalisation of asylum proceedings are the most widespread barriers that States around the globe implement to keep refugees out, and consequently prevent their access to international protection. In a global refugee context lacking an international court to interpret the 1951 Refugee Convention (RC), the burden of assessing the compatibility of these barriers with the RC lies on domestic and supranational courts. These separate jurisdictions are interpreting the same treaty, are often presented with similar factual circumstances, and have a duty to uphold the rule of law. Yet, we do not know if courts around the globe have systematically yielded similar or different interpretations on the compatibility of State-developed barriers with the RC; and if common patterns have developed, whether or not they uphold those barriers in light of the RC. Despite these overarching problems, the literature has, so far, had a piecemeal approach; we thus lack an empirically driven socio-legal comparative analysis of the role of courts in interpreting the right to access asylum. ACCESS will introduce an empirically driven theoretical model of how domestic and supranational courts develop international refugee law (IRL) and advance the executive driven model of migration governance in response to State-developed barriers. More specifically, we will investigate: 1) how do judges apply the same legal treaty (RC) and related international norms in different political and socio-legal contexts?; 2) to what extent are there any discernible patterns in the courts decisions related to barriers to asylum (either restricting or expanding access to asylum)?; 3) what are the socio-legal factors influencing adjudication?; and 4) how have courts devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Causes and consequences of aberrant mRNA translation in cancer' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Shortages in amino acids are weapons in the warfare between tumor cells and tumor-infiltrating lymphocytes. Tumor cells enhance or inhibit the production of key amino acid metabolites to stimulate oncogenesis and suppress anti-tumor activity. A key player in this battle is tryptophan. Activated T cells secrete interferon-, which upregulates IDO1 enzyme to catabolize tryptophan to kynurenine in target tumor cells. While kynurenine suppresses T-cell function, its production limits tryptophan availability in tumor cells. Importantly, as tumor cells almost invariably deregulate mRNA translation to promote proliferation and metastasis, the consequences of tryptophan shortage are major. It provokes aberrant mRNA translation at tryptophan codons, resulting in ribosomal frameshifting and tryptophan to phenylalanine (W>F) codon reassignments (substitutants). This aberrant mRNA translation alters protein function and enriches the landscape of neoepitopes at the surface of tumor cells. Based on these observations, I hypothesize here that the detection of aberrant proteins in cancer specimens can reveal additional key processes of cancer progression beyond tryptophan that can be utilized for cancer therapy. To explore this exciting new idea, I designed three work packages (WPs):WP1 will expand the landscape of aberrant mRNA translation in cancer and link them to cancerous events. Preliminary results pinpoint arginine, histidine, and leucine. WP2 will generate reporter assays, set up functional genetic screens, and identify, validate, and explore key regulators of aberrant mRNA translation.WP3 will study the functional consequences of aberrant mRNA translation, and introduce novel therapeutic concepts.Altogether, this proposal will employ our recent discoveries of aberrant mRNA tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of intercellular communication and DNA double strand breaks in the induction of bystander effects', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The biological processes mediating bystander responses are incompletely understood despite the relevance of this phenomenon to radiation protection and radiation therapy. The present proposal contributes to the elucidation of the mechanisms underlying bystander effects by evaluating intercellular communication as a determinant of the response, and DNA double strand breaks as initiating lesions. Using biological model systems with conditional induction of intercellular communication and diverse experimental approaches, some of which are developed and tested here, we aim to investigate the induction kinetics of by stander effects in cultured cells and evaluate their contribution to the response of tumors growing in nude mice to ionizing radiation. The results should allow the definition of targets for pharmacological intervention to protect humans from the adverse effects of ionizing radiation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Minho Year of Physics' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Portugal spends nowadays slightly above 0.7 % of its GDP in research and technology every year. Such a figure significantly departs from the 3 % of GDP goal of the European Union for 2010. To help achieve this goal, we believe on the need for an active e ffort of all interested actors, and to reach this end, we planned a series of activities to promote Physics, to raise the taste for scientific culture, to make the general public aware of Physics, and Science and technology in general, to expose students to our research laboratories to motivate them for scientific careers, and to show the importance of research, either basic or applied, in the pursue of a wealthier society. These steps are of even greater relevance in Portugal, a country still emerging from an intensive labor industrial tissue, but presently at the brink of emerging technology driven industries. The proposed plan includes activities like colloquia for the general public demonstrating the power of brilliant ideas of physicists with dir ect consequences to our everyday life, debates and workshops to help teachers teach better, and to engage students of all grade levels to learn by practicing, in order to implement the strategies stated in the Minho Year of Physics" proposal. To make ou r activities far more reaching, we also intend to have a broad class of web contents, including forums, science games, and virtual experiences to broaden the chance of others to participate, even if they cannot be physically present."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Circular fuel supply for air transport via negative emission HTL conversion' in the context of a Horizon Europe call.

assistant: **Objectives**

Achieving climate neutrality in Europe requires large volumes of truly sustainable fuels to provide long-term solutions for transport sectors where direct electrification is not viable. CIRCULAIR addresses this challenge with an integrated biofuel pathway that produces cost-effective aviation fuels and generates negative emissions. Key innovations of CIRCULAIR involve a close thermal coupling of hydrothermal liquefaction (HTL) conversion, based on abundant and available agricultural residues and lignocellulosic crops, with exothermic wet oxidation of HTL process water. In this way, autothermal operation can be achieved, carbon is fully utilized, and the process water disposal problem of HTL is solved. In addition, CIRCULAIR develops innovative approaches to upgrade HTL biocrudes to jet fuel and accelerates the approval of HTL fuels for civil aviation. The biomass resource utilization is maximized by developing valorisation schemes for all relevant side streams along the process chain. In particular, acetic acid will be extracted from residual process waters and methanol will be synthesized from effluent gas streams and renewable hydrogen. Importantly, CIRCULAIR will close a knowledge gap regarding the utilization of fixed carbon in the HTL solids for carbon sequestration and soil amendment, i.e. for a negative contribution to the carbon balance. The targeted overall net-negative emission will be quantified based on life cycle analysis. Finally, techno- and socio-economic analyses will identify important benefits and trade-offs associated with the advanced biofuel process. In summary: CIRCULAIR will investigate and develop an innovative process for resource-efficient production of sustainable aviation biofuels alongside further marketable renewable chemicals and fuel pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Meridional overturning exchange with nordic seas' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Using a combination of different observational techniques and model experiments, MOEN will monitor the total Atlantic inflow to the Nordic Seas and the Ireland-Scotland return overflow of dense water into the Atlantic during a two-year field phase and will study trends and variations of the fluxes on longer time scales. MOEN is a self-contained project but also acts as a component of the Arctic-Sub arctic Ocean Flux (ASOF) study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'UltraFast wind sensOrs for wake-vortex hazards mitigation' (UFO).

assistant: **Innovation**

The UFO project aims at ensuring aviation safety at current high standards or even better, regardless of air transport growth, through Wake-Vortex Advisory Systems improvement, in connection with SESAR P12.2.2 project. UFO research works will address a wide range of innovative technologies through studies of new Ultra Fast Lidar/Radar Wind & EDR (Eddy Dissipation Rate for turbulence) monitoring sensors, usable for Wake-Vortex Hazards Mitigation, but also for severe Cross-Wind, Air Turbulence and Wind-Shear.Constrained by high update rate and accuracy requirements needed for wind measurements, 2D electronic scanning antenna technology based on low cost tile will be explored for X-band radar through a development of a tile mock up as well as a new high power laser source of 1.5 micron Lidar 3D scanner with higher power.In addition, new design tools will be developed through simulators, able to couple Atmosphere models with Electromagnetic, Radar and LIDAR models. In parallel, advanced Doppler signal processing algorithm will be developed and tested for 3D wind field and EDR monitoring, including the algorithm for the resources management of the different sensors. Comparison with already existing sensors as C band meteorological radar and S band ATC radar, but also ADS-B Downlink will be studied.Calibration of the ground sensors (Lidar, X band radar, C band radar with ADS-B datalink) and the simulators will be achieved through a set of experimental trials in Munich and Toulouse. In Toulouse, an aircraft equipped with airborne probes will enable in situ comparison.Coordination with SESAR, through Eurocontrol, as associated partner, airports as End user in the UFO steering committee, will be favoured.The team is composed of the main experts in Europe of the domain: 2 large c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Intergalactic Medium as a Cosmological Tool' (COSMOIGM), addressing dissemination and exploitation.

assistant: **Impact**

The cosmoIGM proposal aims at investigating the role of the Intergalactic Medium (IGM) as a cosmological probe and  at exploiting  the many IGM-related sinergies between observational cosmology, galaxy formation and fundamental physics. The IGM is a unique cosmological observable as it probes 3/4 of the present age of the universe, it contains up to 80% of the baryons and is sensitive to scales that are not measured by other data. In the last decade, astronomical data sets have started to be widely used by the scientific community to address important physical issues such as: the nature of the dark matter and dark energy components and their evolution;  the physical properties of the baryonic matter; variation of fundamental constants; feedback processes by galaxies, etc. For example, results obtained from astronomical data are nowadays comparable to those obtained by ground based physics laboratories (e.g. neutrino masses).  This proposal will rely on observations of the IGM at high and low redshift and will interpret them by means of state-of-the-art computational facilities in order to firmly establish the (yet controversial) role of the IGM as a probe for cosmology and fundamental physics. Moreover, we aim at exploring the galaxy-IGM interplay at a crucial stage of the cosmic history when the universe was few Gyrs old and star forming galaxies were strongly affecting the dynamical, thermal and chemical properties of the IGM. The hosting institution,  Trieste Observatory, and the Trieste Area (ICTP, SISSA and Trieste University) have a long-standing expertise on the topics above. We foresee that the present interdisciplinary proposal will have a strong scientific impact and will help the P.I. to consolidate its independence and to create his first research team.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Systems Biology of Colorectal Cancer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Colorectal cancer (CRC) is one of the most common cancers in both males and females, and it is perhaps the best understood of all epithelial tumors in terms of its molecular origin. Yet, despite large amount of work that has concentrated on understanding of colon tumorigenesis, we still do not know the full complement of molecular lesions that are individually necessary – and together sufficient – to cause colorectal cancer. Neither do we understand why some specific mutations that are relatively rare in other tumors (e.g. loss of the APC tumor suppressor) are extremely common in colorectal cancer. We propose here to use the tools of systems biology to develop a quantitative and comprehensive model of colorectal tumorigenesis. The model will include a “wiring diagram” that identifies cell-type specific and oncogenic pathways that contribute to colon tumorigenesis, and explains in molecular detail how a genotype of an individual CRC leads to activation of downstream genes that drive uncontrolled cell growth. This model will subsequently be used to find novel therapeutic targets, to guide genetic screening to identify individuals with elevated risk for developing CRC, and to classify patients into molecular subgroups to select the treatment combination which is optimal for each patient (personalized medicine). The specific objectives of the SYSCOL project are:1. Identify genetic markers for individual risk using genotyping and sequencing of germline DNA from sporadic and familial CRC cases and controls2. Identify genes and regulatory elements that contribute to colorectal cancer cell growth3. Use data from Aims 1-2 to develop a quantitative model for colorectal tumorigenesis4. Apply the model for identification of high-risk individuals, for molecular classification of the