RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'What makes our subjective perception of the world unique?' (WMOSPOTWU).

assistant: **Concept**

We commonly assume that our perception of the world is constant and seamless. This intuition belies the dramatic differences in the perceived quality of a stimulus even within the same individual when it is shown at different spatial locations or different times. Conventional studies of perception treat such unique patterns of perceptual variability as noise and seek to eliminate them by averaging across individuals; however, studying individual heterogeneity in perceptual function can reveal insights into how the brain makes our subjective view of the world unique and personal. All perception must arise in the brain. Despite that, the neural substrates underlying this perceptual heterogeneity remain unknown.Here, I therefore propose a project to investigate cortical and perceptual heterogeneity in human volunteers using a combination of behavioural psychophysics, functional magnetic resonance imaging and transcranial magnetic stimulation. I will explore the heritability of these maps to better understand the factors underlying perceptual heterogeneity. Together, these experiments will provide convergent evidence about how the functional architecture of human sensory cortex gives rise to an individual's unique perception of the world. This will make it possible to reconstruct how an individual perceives the environment, thus giving an insight into their “mind's eye,” and has implications for patients with pathological sensory discontinuities (such as scotomas) or hallucinations, as it will enable us to reveal how they perceive their environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Function of Hippocampal and Cortical Memory Replay in Humans' (REPLAY).

assistant: **Concept**

How does the brain use past experiences to shape future actions? Over two decades ago, research in rodents has made a remarkable discovery that may provide key answers to this fundamental question. Researchers found that while rats were sleeping, activity in their hippocampus seemingly retraced the animals’ previous trajectories in a maze, only much faster than in real time. This phenomenon, known as replay, has become a major focus of neuroscientists and even artificial intelligence researchers over the past decades. The resulting research demonstrated that replay is prevalent during wakeful resting, related to memory, planning and reward processing, and shares similarities with machine learning algorithms. These findings suggest that replay may be a fundamental mechanism behind memory consolidation and the computation of optimal behavior. Yet, despite the significance of this phenomenon, little is known about replay in the human brain. The major reason for the lack of knowledge are difficulties to measure fast neural processes non-invasively in the human hippocampus. The main goal of the proposed research is to overcome these obstacles, and to provide deeper insights into replay in humans. To achieve this, we will use a novel fMRI analysis method that tests whether the transitions between successive fMRI patterns during rest or sleep exhibit non-random relations to the temporal structure of previous experiences. Using this approach, the proposed research will provide insights into four cognitive and computational aspects of replay in the human brain: (1) the coordination of hippocampal replay with activity in other brain areas, (2) the effects of reward and planning on content and direction of replay, (3) the role of replay during sleep and its relation to sleep spind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Circadian rHythms and theiR associatiON with myOPIA' to be submitted under Horizon Europe.

assistant: **Abstract**

Myopia or short-sightedness is a refractive error caused by excessive eyeball elongation, resulting in distant objects appearing blurry. Its global prevalence is increasing rapidly and is estimated to affect half of the global population by 2050. Several recent studies have suggested a link between circadian rhythms and eye development. An analysis at the Estonian Biobank revealed a robust association between myopia and an individuals sleep timing preference, or chronotype. Individuals with late chronotype were more likely to have myopia, while early chronotype was associated with hyperopia. This project, CHRONOPIA, aims to uncover the underlying mechanisms and directionality of this relationship. It seeks to understand how circadian rhythms influence eye growth and how refractive errors, in turn, impact circadian rhythms. The effect of circadian rhythms on refractive development will be studied in mice by employing various circadian biology paradigms with simultaneous monitoring of refractive development. The impact of refractive errors on circadian rhythms will be evaluated using the mouse model of lens-induced myopia and hyperopia, circadian phenotyping techniques, retinal transcriptomics, and ex vivo assessment of retinal circadian rhythms. Finally, through genome-wide gene-based association studies, this project will analyse the molecular similarities between the mouse model of myopia and human myopia. This provides an opportunity to discover novel genes and pathways associated with human myopia and to determine how well the mouse model of the disease models human myopia on a molecular level. By elucidating the interactions between refractive errors and circadian rhythms, we aspire to contribute valuable insights into the molecular mechanisms that could guide the d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Electronic data interchange for the European maritime industry'.

assistant: **Concept**

The shipbuilding industry is characterised by the complexity of its products, concurrent processes and a large number of external companies taking part in the manufacturing process. Enabling these companies toward more efficient cooperation is one of the major challenges for the European shipbuilding industry, by reducing costs to gain a competitive edge against the low wage countries. One possibility of overcoming the cost barrier is the outsourcing of parts of the product development and production tasks. This in turn increases communication and organisational costs. IT and newly designed business processes are the enabling means to overcome this approach of outsourcing.Shipyards to date are experiencing difficulties in developing and introducing special branch standards and constraining suppliers to use such standards because of the heterogeneous supplier structure. The standardisation problem can however be solved by means of an internationally accepted standard. This is the EDIFACT (Electronic Data Interchange for Administration, Commerce and Transport, ISO 9735) for commercial data. This standard defines a significant number of messages for different applications (e.g. order, delivery, inquiry etc.) which reduces the communication overhead for the information exchange between companies. EDIMAR will focus on the commercial and design-refinement business chains of the shipbuilding process.In shipbuilding, even major supply products are not standard off-the-shelf products. Therefore many products 'made-to-order' require a highly intensive data-exchange between shipyard and supplier. The international standard to support the exchange of product data for manufacturing, STEP, (Standard for Exchange of Product Model Data) will be extended by EDIMAR for exchange of engine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Functional and advanced insulating and energy harvesting/storage materials across climate adaptive building envelopes'.

assistant: **Innovation**

Buildings account for around 40% of total energy use and 36% of CO2 emissions in Europe  . According to the recast Directive on the energy performance of buildings (EPBD)   all new buildings after 2020 should reach nearly zero energy levels, meaning that they should demonstrate very low energy needs mainly covered by renewable energy sources. EU 2030 targets aim at least 40% cuts in greenhouse gas emissions (from 1990 levels), at least 32% share for renewable energy, at least 32.5% improvement in energy efficiency , and 80% reduction of greenhouse gas (GHG) emissions by 2050 . Therefore, an urgent need is present for a deep market transformation by deploying efficient materials and technologies in the construction sector to support the real implementation of nearly zero-energy/emission and plus-energy buildings with high indoor environment quality across Europe. As energy consumption of buildings depend strongly on the climate and the local weather conditions, additional aspects arise (such as environmental, technical, user experience, functional and design aspects) on the selection of the appropriate material and technical components installation for a successful implementation of nZEBs. Further, this selection of materials and design for climate should be based on a circular economy perspective considering environmental, economic and social effects along value chains. Better utilisation of products and resources via reuse-repair-recycling is essential in achieving a transformation from a linear to a circular economy model. Many of the current materials and technical systems still have varying degree of difficulty in accomplishing a circular perspective. Material and technical system development in a ZEB framework should focus on building thermal performance improvemen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The First Cell Culture Platform that Enables Affordable Cell Therapies at a Large Scale' (Facer), addressing dissemination and exploitation.

assistant: **Impact**

Cell therapy has shown promising results for treating and curing a large range of diseases, from cancer to diabetes. The principles of cell therapy are easy to describe: cells (possibly modified) are injected into patients. Cell therapy is now a reality in Europe: in August 2018 the first two treatments for patients with blood cancer were approved; more of them are about to successfully conclude the approval path. What hinders the large-scale uptake of cell therapy is its costs: culturing enough cells of high quality requires specialised personnel and infrastructure, which only a few centres can afford. The market asks for a scalable cell culture platform that can produce large quantities of high quality cells at much lower costs than done nowadays. To address this need, we have developed the Facer – the first fully-autonomous cell culture platform. The Facer can manufacture billions of high-quality cells starting from the small quantity (about 500,000 cells) of a tissue biopsy without the need of human intervention, thanks to a unique patented iterative process. Our product is at TRL 7; its performances, in terms of quality and costs, are superior to any competitor commercially available. We have developed the Facer over the course of 5 years thanks to cash investments of over €3 million. In the Phase 2 project we will finalise the product, perform a validation with external partners, prepare the product for CE marking (our product is not a medical device), and find a distributor and a launching customer. We will initially tackle the European market to then expand globally once that the local regulatory barriers are overcome. In 2024, after 5 years from the first sale, our turnover will surpass the €60 million and our EBITDA will be over €36 million. Our innovation can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Microscale Chemically Reactive Electronic Agents' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal of the project is to give electronics and chemistry an equal autonomous say in programming complex chemical constructions, processes and analyses at the nano and microscales: the same scale where information processing in living systems occurs – where to construct is to compute". To do this MICREAgents (MIcroscopic Chemically Reactive Electronic Agents) will develop novel electronically active microreactor components, called lablets, that self-assemble at a scale less than 100 µm, approaching that of living cells. The project will integrate the necessary components to ensure autonomous action of millions of these "very smart chemicals", including electronic logic, supercapacitors for power, pairwise coupling for communication, programmable chemical sensors and electronic actuation of chemical processing. Key examples of MICREAgent actuation are to reversibly switch their association, load or dose chemicals, modify surfaces, initiate reactions and control locomotion in complex chemical environments. MICREAgents lablets can join forces to communicate both chemicals and electronic information in order to solve complex tasks, acting as smart collective agents of chemical change. Like cells, they will be essentially genetically encoded, but with chemical and electronic memories, translating electronic signals into constructive chemical processing and recording the results of this processing. They will also reversibly employ DNA molecules as chemical information, for example to control surface-surface binding of lablets, or to program chemical sensors, not to synthesize proteins as in cells. The project builds on pioneering FET-funded work towards electronic chemical cells, taking a giant stride to cell-like microscopic autonomous chemical electronics with self-assem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Big Data Analytics of Digital Footprints' (BigFoot) targeting Seventh Framework.

assistant: **Abstract**

The amount of digital information in our world has been exploding and new technologies and services will continue to fuel exponential growth of large pools of data that can be captured, stored, and analyzed. Nowadays, however, tools and services to store, process and interact with data are still in their infancy, represented by scattered solutions that fall short in having a unified vision, that lack common interfaces, and that only offer best-effort services.<br/>The aim of BigFoot is to overcome current drawbacks by designing, implementing and evaluating a Platform-as-a-Service solution for processing and interacting with large volumes of data. The BigFoot stack -- which builds upon and contributes to the Apache Hadoop ecosystem and the OpenStack project, in addition to creating new open source components -- features automatic and self-tuned deployments of storage and processing services for private clouds, going beyond best-effort services currently available in the state-of-the-art. BigFoot takes a novel, cross-layer approach to system optimization, which is evaluated with a thorough experimental methodology using realistic workloads and datasets from two representative  application, namely ICT Security and Smart Grid data analytics. In addition, BigFoot aims at making data interaction easy by supporting high-level languages (for batch oriented analytic tasks) and by taking a service-oriented approach to support and optimize latency sensitive queries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intelligent Modular Multi-sensor Networked False Alarm Free Fire Detection System' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The main objective of IMOS project is the development and the demonstration of a false alarm free fire detection system for large buildings and production plants. This will be achieved by the development of an intelligent multisensor microsystem (IMS) comprising:An optical multi sensor (OMS), which measures the scattered light and absorptions at least by two different wavelengths and at least by two different scattering angles in order to discriminate between fire and non-fire situations,A multi-gas-sensor-system (MGS), which is able to measure at least CO, CO2, NO, unburned hydrocarbons and alkaloids,A neural network running in an embedded system, which will identify smoke fingerprints using all the available sensors information, and teleservice.Work description:First of all, we will conduct fire tests according to EN54 and also tests with paper fire and tobacco smoke to identify the fire and non-fire patterns. We will analyse and evaluate the results of these tests in order to select suitable gas and optical multi-sensors for the measurement and identification of fire products. Then, the final specification of the system architecture and algorithms will be set up. Two workgroups will design and develop the multi-gas-sensor-system (MGS) and the optical-multi-sensor (OMS) in parallel. The MGS will measure at least CO, CO2, NO, unburned hydrocarbons and alkaloids. The OMS will measure the scattered light at different wavelengths and at different scattering angles. The integration of the developed MGS and the developed OMS will be accompanied by the development of the neural network running in an embedded system which will be equipped with a LON network for teleservice and telemaintenance.Two prototypes will be manufactured for final testing and field tests. The final tes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In silico tools to reduce the use of animals in toxicity testing for bio-reactive chemicals' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

European Union legislation for the Registration, Evaluation and Authorisation of CHemicals (REACH) calls for the toxicological assessment of a large number of substances. There will be a requirement to use in silico methods such as (quantitative) structure-activity relationships ((Q)SARs) to supplement the information obtained from other means.The proposed project will enable the development of in silico tools for toxicity prediction that may be used to assess REACH chemicals. Industry and society within the European Union require these tools as suitable alternatives to animal testing. Specifically, the transfer of knowledge to the host institution will take place in the areas of reaction chemistry and molecular orbital theory for toxicity prediction, as well as for software development. To achieve this, the reaction mechanisms associated with reactive toxicity will be established. For such mechanisms, novel molecular orbital approaches to predict (electrophilic) reactivity associated with toxicity, where such algorithms are currently lacking, will be developed. These novel predictive molecular orbital approaches and algorithms will be used to estimate toxicity, for previously poorly predicted endpoints, through the development of (Q)SARs.In addition, the relationships between reactive toxicity endpoints will be investigated. These innovations will lead to the development of a novel software application that is able to calculate the newly developed indices for reactivity, to assist in the rational prediction of toxicity. Such an application will be applied in Integrated Testing Strategies as a part of on-going activities to support REACH e.g. as a plug-in for the planned OECD (Q)SAR Application Toolbox. The project will require the recruitment of two experienced researc