RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Genome dynamics of the human fungal pathogen Candida albicans' to be submitted under Seventh Framework.

assistant: **Abstract**

This CIG grant proposes will support the Integration of Professor Judith Berman, who is currently a Full Professor at the University of Minnesota, in the United States and who will move to a Full Professor position at Tel Aviv University.  Professor Berman is a highly regarded research focusing on the biology of Candida albicans, an important fungal pathogen of humans. The work proposes to analyze the dynamic processes by which this fungal pathogen evolves resistance to currently used antifungal drugs.  The two objectives are to: 1) to characterize the types of long-range changes that arise following exposure to an extreme stress (e.g., antifungal drug), including the mechanisms that give rise to them and the dynamics with which they appear and 2) to establish how specific genome changes affect the fitness/growth of individuals and the population either in the presence or in the absence of the drug.  Subaims for objective 1 will include: developing and adapting tools for the analysis of genome structure, including detection of long-range events and visualization of ultra high resolution sequencing data; Constructing sophisticated genetic strains; Identifying growth conditions and genetic factors that affect the frequency of specific genome changes; identifying and characterizing rare isolates that undergo multiple genome changes; and following the dynamics of the evolution drug resistance. Subaims for objective 2 will include: optimizing assays measurement of fitness/growth of individuals and populations over time; and comparing the fitness/growth of strains that acquired different genome changes.  These objectives and subaims will facilitate the integration of Prof. Berman into the European Community of Life Sciences through her interdisciplinary approach to analyzing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Small molecules activating RET for the treatment of Parkinson's disease'.

assistant: **Concept**

Parkinson’s disease (PD) is caused by degeneration and progressive loss of dopaminergic (DA) neurons of the substantia nigra. In Western countries more than 6 million people live with PD. Currently no cure for this disease is available, existing therapeutic strategies alleviate PD symptoms but do not influence its cause or in other words do not prevent or slow down degeneration of DA neurons. Glial cell line-derived neurotrophic factor (GDNF) is one of the few molecules able to protect and repair DA neurons in animal models of PD. GDNF protein and the related factor neurturin were tested in five clinical trials, but the results have been inconclusive. The pharmacokinetic properties of these proteins complicate their therapeutic development. They do not pass blood-brain-barrier (BBB). Moreover, these factors diffuse poorly from the site of injection.The purpose of current proposal is to combine expertises of the academic and industrial partner in the fields of computational/medicinal chemistry (industrial participant), molecular/behavioural neuroscience and neuropharmacology (academic participant) to develop small molecules passing BBB and efficiently protecting and repairing dopaminergic neurons in vivo. We have developed an initial set of hits that activate GDNF receptors that at 1-10 uM concentration protect and repair DA neurons in vitro. We plan to optimize existing molecules and develop new ones to achieve an active concentration in the range 1-10nM using rational drug design approaches and cell-based screening methods developed by us.Successful compounds will be tested and optimized for ADMET and pharmacokinetic properties and studied in rat models of Parkinson’s disease to determine their safety, efficacy and other pharmacological characteristics. The expected ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Evaluating effects of rumen originated lipopolysaccharide on the pathogenesis of subacute rumen acidosis'.

assistant: **Innovation**

Subacute ruminal acidosis (SARA) is a well-recognized digestive disorder of high yielding dairy cows that has a negative impact on both animal health and herd profitability. It is associated with increased ruminal lipopolysaccharide (LPS), and LPS has been reported to participate in the pathogenesis of SARA. LPS from E. coli (LPS-E) has been used to study its effects on the SARA pathogenesis. Our preliminary data showed that LPS-E participates in the pathogenesis of SARA by directly increasing the starch-digesting and lactate-producing ruminal bacteria and the genes involved in the LPS biosynthesis process. However, we do not know if LPS-E would be representative of LPS from ruminal bacteria (LPS-R), and thus we do not know how LPS released from SARA cows participate in the pathogenesis of SARA. Therefore, the objectives of this proposal are to 1) isolate LPS from the rumen bacteria by inducing SARA nutritional model in batch culture (WP1, 2, 5, 6 & 7); 2) and compare the effects of LPS-R with the LPS-E on ruminal fermentation, bacterial community composition (BCC), and function by using 16S rRNA sequencing and RNA sequencing in batch culture to elucidate the roles of LPS on the pathogenesis of SARA (WP1, 3, 4, 5, 6 & 7). We hypothesis that 1) LPS from ruminal bacteria could be collected from culture media through inducing SARA nutritional model in batch culture; 2) LPS-R and LPS-E will have different effects on ruminal fermentation, BCC, and functions, but both of the two LPS sources would stimulate the bacteria and genes involved in starch digestion, lactic acid production, and LPS biosynthesis. We expect that our proposal could 1) fulfill the gap of knowledge of the role of LPS on the SARA pathogenesis; 2) provide the direction for industries to develop the products
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Innovative Technology for District Heating and Cooling' (InDeal), addressing dissemination and exploitation.

assistant: **Impact**

Challenged by climate change, and coupled with the need to secure sustainable economic growth and social cohesion, Europe must achieve a genuine energy revolution to reverse present-day unsustainable trends and live up to the ambitious policy expectations. A rational, consistent andfar-sighted approach to heating and cooling is key for ensuring such transformation.Toward this direction, district heating and cooling systems need to be more efficient, intelligent and cheaper. InDeal project will offer an innovative platform that will impose a fairly distribution of heating and cooling among the network’s buildings by: (i) real – time energy consumption data gathering via artificial intelligent meters, (ii) identifying and evaluating the network’s buildings’ need and demand for heating and cooling depending to their energy efficiency, energy consumption and type of building (EDP tool), (iii) predicting the short-term and long-term weather conditions and forthcoming need for heating and cooling (EDP tool), (iv) monitoring and control the level of energy stored in network’s storage stations and substations (SMT), (v) 24/7 monitoring of the DHC system by a central control platform and (vi) minimizing heat losses via novel pipe design solutions and innovative insulation materials. The target of InDeal is to turn the current DHCS into a new next-level automated DHCS that will guarantee the increase of the overall energy efficiency of the system accomplishing a fairly distribution of heating and cooling energy demands. In light of this, InDeal will make a significant step forward contributing to wider use of intelligent district heating and cooling systems and integration of renewables, waste and storage.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Plant life assessment network' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

PLAN PROJECT OVERVIEW:The Plant Life assessment Network (PLAN) is a Type II Thematic Network encompassing a range of projects contributing to the four essential elements, Inspection Instrumentation and Monitoring, Structural Mechanics and Maintenance which are a pre-requisite for improved efficiency and safety of European industrial plant. The general aims of PLAN include:- to provide the opportunity to organise regular meetings, workshops, seminars and conferences at which key research issues can be discussed by both contractors and customers leading to improved work specification;- to secure added value by organising the individual projects and co-ordination their research into dedicated research clusters and horizontal themes;- to achieve teamwork by the networking principle, enabling efficient technology and innovation transfer between different partners and industries and cross fertilisation and dissemination of results to a wider audience;- to exchange high level technical information thereby creating an exploitation environment and improved awareness to influence the drafting of European codes and standards;- to provide a contribution from over 50 Projects representing many hundred predominantly industrial organisations towards the future shaping of European Union research priorities and activities in the area of plant life assessment.EUROPEAN DIMENSION AND PARTNERSHIP:The benefits to Europe and industry include, amongst others;- heightened awareness of research and development activities within industries;- the EC becoming a more informed customer;- a contribution to safer and more reliable plant;- improved communication between industries;;- working with new partners from diverse industries;- the opportunity to draw up a list of key personnel in the European en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Aero-Thermodynamic Loads on Lightweight Advanced Structures II' (2007-2013).

assistant: **Concept**

ATLLAS II is a logical follow-up of a recently finalized FP6 project which has as objectives the identification and assessment of advanced light-weight and high-temperature resistant materials for high-speed vehicles up to Mach 6.The material requirements are first defined through an in-depth feasibility study of a Mach 5-6 vehicle. The consortium has now this capability at hand as they can rely on a first set of validated tools, material databases and valuable experience acquired during ATLLAS-I. Starting with a preliminary aero-thermal-structural high-speed vehicle design process, further multi-disciplinary optimization and testing will follow to result into a detailed layout of an independently European defined and assessed high-speed vehicle. Special attention will be given to alleviate sonic boom and emissions at high altitudes.Throughout the design process, the aero-thermal loads will define the requirements for the proposed materials and cooling techniques needed for both the airframe and propulsion components. The former will focus on sharp leading edges, intakes and skin materials each coping with different external aero-thermal loads. The latter will be exposed to internal combustion driven loads. Both metallic (Titanium Matrix Composites and Ni-based Hollow Sphere Stackings) and non-metallic materials (Ceramic Matrix Composites and Ultra High Temperature Composites) will be evaluated.Combined aero-thermal-structural experiments will test various materials as specimens and realistic shapes at extreme conditions representative for high flight Mach numbers. Both static and cyclic tests at low and high temperatures are planned including the evaluation of their durability in terms of long duration exposure to the harsh flight conditions. The materials assigned to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cirrus cloud mimic surfaces in the laboratory: organic acids, bases and NOx heterogenous reactions' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

It is proposed to investigate the mechanisms of heterogeneous reactions taking place between the important tropospheric pollutants, NO2, NO and NH3 and certain simple carboxylic acids on water-ice surfaces. The systems employed will be relevant to the ch aracterization of \missing\" atmospheric chemistry, which has been suggested to be driven by cirrus cloud particulates. The core methodologies involved are based upon the successful water-ice, thin-film FT-RAIR studies previously performed in Professor Sodeau\'s laboratory. The experiments will be augmented by the complementary expertise possessed by Dr Hellebust to characterise ice surfaces and their catalytic activity by a variety of non-spectroscopic methods. Appropriate theoretical and empirical thermodynamic models will be used to consolidate the experimental results. All output information obtained will be made available to atmospheric modellers in order to improve our understanding of proposed sinks for the carboxylic acids and the release o f compounds such as HONO by heterogeneous processes currently assessed to be important but with little confirmatory experimental proof"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'YOYO 2001 : Ocean Odyssey', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

It is proposed to develop and test out an autonomous system able to profile at a fixed location from 1000 meters up to the very surface and transmit in real time its data to land. This system will collect fundamental physical, bio-optical, geochemical and biological observations describing the ocean state over the whole water column with a particularly refined resolution in the upper 100 meters. The proposed instrument will be able to maintain a multidisciplinary time-series station autonomously. The instrument will be able to cover a broad spectrum from small time scales of a day or even less to years. It will be able to sample slow processes as well as episodic and short events. The scientific objective behind this development is to monitor over the mixed layer and the main thermocline the complex physical and biochemical interactions governing the carbon cycle and its associated elements in the ocean. Autonomous profiling up to the surface will open a wide range of possible scientific applications ranging from specific process studies to climate monitoring. Repeated autonomous profiling to the very surface at a fixed location is a scientific need (proper sampling of the mixed layer where most of photosynthetic activity takes place), a major innovation and a major technical challenge. To integrate a multidisciplinary sensor system gathering fundamental physical, bio-optical, geochemical and biological observations requires also major innovative developments. The project integrates 6 leading laboratories from 4 countries and one leading european industrial. This gives the project the necessary completeness so that it can reach its objectives. The wide partnership also enables an effective dissemination of the technology from the project to ensure that the technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Development of a new Domestic Heat Recovery Technology for Low Grade Heat in Waste Water (LOW-HEAT)' (LOW-HEAT) under Sixth Framework.

assistant: **Objectives**

Low-grade heat (in the range 25-80C) in the form of a waste-water stream discharged into sewers, is an everyday by-product of European homes. It is generated from a variety of domestic appliances such as washing machines, dishwashers, shower units, baths, sinks etc. In the EU, there an estimated 58 million dishwashers, 232 million washing machines and 63 million showers units, with at least 90% of the input energy going into heating the water for these appliances. This equates to approximately 26,500 terra Joules of thermal energy. To date, this source of energy from waste-water has been largely ignored and not recovered/recycled. Our solution is to develop a low grade heat exchanger for use in the domestic sector to recover over 40% of the heat energy from this waste water to supplement domestic boilers. In so doing we aim to reduce the overall energy consumption of domestic dwellings by 7%, saving over 1000 kWh per dwelling per year or expressed as a European total saving of 10 billion kWh of energy at a target market penetration of 6%.To achieve this aim the proposed research needs to develop new scientific knowledge and understanding relating to the heat transfer relationship of low grade low flow fluids. Particularly the effect of surface roughness on the heat transfer coefficient (h) and the generation of turbulent flow. This new scientific knowledge will lead to the understanding on how to develop and enhance the efficiency of heat exchanger for low-grade applications. Such a system will represent a massive leap beyond state-of-the-art, represented by existing concentric tube heat exchangers which are mainly targeted at the high-end of heat recovery from industrial processes. The plumbing sector, (with over 150 000 SMEs) has been traditionally slow to innovate an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Training scientists to develop and Image materials for Tissue Engineering and Regenerative Medicine' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The iTERM ITN (4 companies, 6 universities) will deliver 12 early stage researchers (ESR) and 1 experienced researcher (ER) trained in imaging, material science, and tissue engineering & regenerative medicine (TERM). For the aging population in the EU donor material is often not available, and artificial tissue needs to be developed to replace and repair damaged tissues. New smart materials have been developed and increasingly these implants are becoming analogous to the tissue they replace. Classical imaging technologies are not equipped to distinguish these implants and consequently, the fate and effect of the used implants cannot be followed. To deliver supra-disciplinary scientists with knowledge necessary to drive this research area forward, to enable product development, and increase Europe’s competitive position, iTERM will provide fellows with individual and centralized training in key elements of imaging, materials science and TERM. During their training, the fellows will develop new materials and implants for TERM as well as state-of-the-art novel multimodality visualization procedures to monitor the behaviour of implants, advancing the field of TERM. iTERM is excellently positioned to achieve the goal to deliver highly employable scientists in the field of imaging and TERM: all iTERM partners are recognized leaders in their field of expertise - ensuring state-of-the-art training possibilities - have highly complementary skills and have extensive prior experience with ITN, integrated projects and Network of Excellence programs, assuring successful achievement of our goals. The inclusion of 4 industrial partners guarantees cross-sectorial training, a highly desired competence. The trained fellows will be highly skilled in different research areas required for m