RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The dynamical evolution of Globular Clusters: From Brown Dwarfs to Blue Stragglers'.

assistant: **Objectives**

Globular clusters (GCs) are the oldest stellar systems in the Galaxy and can be regarded as fossils from the violent epoch of Galaxy formation. The lifetimes of their very low mass main sequence stars (VLMMSSs) and brown dwarfs (BDs) are much longer than the age of the Galaxy, and thus samples of the VLMMSSs and BDs in GCs can provide us with important insights into the earliest stages of star formation in the Galaxy. Moreover, BDs represent a link between the lowest mass stars and giant planets, and thus are important for our understanding of stellar structure and evolution as well as star and planet formation. However, despite their importance for a range of astrophysical fields, our knowledge about old, metal-poor VLMMSSs and BDs is very limited. In fact, not a single BD has so far been detected in any GC. One goal of this project is to remedy this situation.GCs are also highly dynamic systems. Indeed, the high stellar densities in their cores boost the formation of exotic populations like Blue Stragglers (BSs) which seem to be present in essentially all GCs. BSs are thought to be the merger product of two or more MS stars. They might have formed dynamically via direct collisions, or from binary evolution. As such, BSs can be seen as a dynamical signature of the present day GC, whereas VLMMSSs and BDs can be regarded as a signature of the early GC at the time of formation.In this project, I will concentrate on both areas of GC research: the faint-end of the MS into the BD regime on one hand, and the cluster BSs on the other hand. Only such a combination, i.e the study of both VLMMSSs, BDs and BSs can provide insight in the dynamical evolution of the GCs as a whole; and test, for the first time, theoretical predictions that regard BDs on one side as the collisional re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enabling SDN ExperiMentAtion in WiReless Testbeds exploiting Future Internet Infrastructure in South KoRea and Europe' (SMARTFIRE).

assistant: **Concept**

The main target at which SMARTFIRE aims is the design and implementation of a shared experimental facility spanning different islands located in Europe (EU) and South Korea (KR). This large scaled facility will promote joint experimentation among EU and KR experimenters, encouraging them to conceive and implement innovative protocols, able to take advantage of the current leading network technologies. Existing testbed infrastructures in EU and KR, already featuring WiFi enabled nodes, wireless sensors and supporting WiMax, LTE and OpenFlow technologies, are going to be extended and federated in the experimental, as well as the control plane. These two directions are going to be supported by the leading experimental frameworks adapted by most EU testbeds, the cOntrol and Management Framework (OMF) and the Slice Federation Architecture (SFA). The OMF framework, currently supporting control and experimentation in wireless islands, is going to be expanded, in order to support experimentation with OpenFlow switches, thus integrating wireless withOpenFlow testbeds. Moreover, unique features, only existing in the KR testbeds will be integrated into OMF, in order to unleash the hidden potential of experimenting with heterogeneous resources. The federation in the control plane that allows assignment of multiple heterogeneous resources under a single slice is going to be developed through the extensions of SFA. Interconnection of the aforementioned islands will take advantage of the GEANT network, in the case of the EU research sites, while the respective KOREN/KREONET will be utilized by the KR sites. The two currently disjoint networks are going to be interconnected via the Trans-Eurasia Information Network (TEIN3/TEIN4) and the Global Ring Network for Advanced Application Deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'From Translation to Creation: Changes in Ethiopic Style and Lexicon from Late Antiquity to the Middle Ages'.

assistant: **Innovation**

An area of ancient written culture from the first millennium BCE, the Ethiopian highlands have been home to a complex literary tradition (predominantly in Ge‘ez) that has no parallel in sub-Saharan Africa. Its emergence was determined by Late Antique culture (Byzantium including Egypt, Pales-tine, Syria, and the Red Sea), Mediterranean cultural encounters, and the African background. The earliest known texts were translations from Greek, later works were adopted from Christian Arabic (esp. Copto-Arabic) literary tradition, in addition to a rich local written production. The complexity of literary history is fully reflected in the changes in grammar, lexicon and stylistic means of the Ge‘ez language. TraCES will for the first time analyze in detail the lexical, morphological and sty-listic features of texts depending on their origins using the achievements of linguistics, philology, and digital humanities. An annotated digital text corpus of critically established texts will be cre-ated. Frequency and collocation analysis will reveal changes in grammatical and lexical choices across centuries. Novel ways of visualization of textual features and intertextual relationships will be offered to provide insights into the structure, history and evolution of texts. The resulting new understanding of the history of the Ge‘ez language and of the Ethiopian creativity and literary activity will help establish features and criteria that may be helpful in determining the origins of texts when the direct ‘Vorlage’ is missing. The literary transmission and dissemination processes will be analyzed by contrasting and connecting Ethiopian Late Antique and medieval heritage with its parallels and antecedents in Near East and Mediterranean, contributing to our understanding of the cultural n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Decoding developmental gene regulatory programs by evolutionary transcriptomics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

An animal’s ability to build itself from a single cell is arguably the most amazing phenomenon of the living world. This process follows from an intricate regulation of the genome, however, deciphering this program remains largely an unsolved problem. The premise of the proposed research program is that an organisms’ regulatory program is a product of evolution and needs to be analyzed as such. My approach is thus to study gene regulation on a phylogeny of organisms, by constructing an atlas of gene expression profiles across developmental stages for a set of 12 nematodes. Such a dataset would constitute the first analysis of genomic regulatory elements with sufficient instances of sequence programs and the corresponding expression regulations to enable comprehensive study. I propose to analyze this dataset with an algorithm that matches specific patterns of presences and absences of expression elements within a homologous group to the corresponding regulatory sequences; putative cis-regulatory sites will then be experimentally tested for the predicted pattern specific expression. In particular, I propose to search for the evolutionary principles such as heterochrony and heterotypy that underlie the evolution of gene regulatory networks, with a special focus on the mode of selection of each element of a gene’s expression profile. As a model system, I will focus on the genetic specification of the C. elegans endoderm, using advanced embryological techniques coupled with inferences from comparisons of endoderm specification across the phylum, to attempt to reprogram its development. In parallel, I shall seek to test for the universality of the observed evolutionary principles, through an analysis of available datasets across the animal kingdom. Progress along this researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gamma-secretase allosteric modulation as preventive therapy in Alzheimer’s Disease' under Horizon Europe.

assistant: **Concept**

The recent advent of therapeutic Aβ-antibodies has validated amyloid plaques as drug targets in Alzheimer’s Disease (AD). They remain expensive, prone to side effects, and clinical benefit is limited. The field needs a safe and cheap drug, preferably a small compound that can be taken orally, and in a preventative way before brain damage has occurred. Despite strong theoretical potential, further clinical development of gamma-secretase allosteric modulators (GAM), is currently hampered by the lack of strong experimental evidence that they are safe and can effectively prevent AD. In this POC we will exploit findings of our ERC grant Cellphase-AD to generate such evidence. We developed an innovative xenotransplantation model beyond the classical mouse models, as it shows not only amyloid plaques, but also the induction of neuro-inflammation, real Tau-pathology, granulovacuolar neurodegeneration, and secretion of Tau biomarkers in the blood, all characteristic of AD (PMID37708272). We will treat this model in collaboration with a contractor with a newly developed compound to demonstrate that this GAM can prevent in a safe and effective way this AD pathology. Using an innovative unbiased ʏ-secretase assay we will provide direct evidence that this GAM, in contrast to the previously failed gamma-secretase inhibitor Semagacestat, maintains normal processing and signalling and does not show mechanistic driven side effects. The experiments aim to support the concept that GAM can be developed as preventative medication in both sporadic and familial AD and to bring the compound forward to clinical trialing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'DESIGN OF EXTREMELY ENERGY-EFFICIENT MULTI-CORE PROCESSOR IN NANOSCALE CMOS FOR MEDIA PROCESSING IN PORTABLE DEVICES'.

assistant: **Innovation**

Many of the future applications that will drive the need for greater performance are naturally highly parallel and process massive data sets, where individual point results are of less interest than aggregate statistics or behavior. Examples include statistical machine learning, rich human-machine interfaces, and physical modeling for games and virtual worlds. In this project, the goal is to develop new highly parallel many-core architectures that exploit the attributes of these parallel, error-tolerant applications to tolerate variability in a projected future 11nm process at very low supply voltages and hence attain large gains in energy efficiency. An integrated cross-disciplinary research program is proposed cutting across software, architecture, and circuits. The architecture is named Raven (Resilient Architecture with Vector-thread ExecutioN). Each Raven core is a single vector-thread lane, with an independent control processor and a vector-thread execution engine, and hundreds of such lanes will be designed to fit in the area budget. Cores with similar characteristics will be identified through the pre-characterization phase and will be grouped to form clusters. Their delay and performance will be notified to control processor, so that it can perform dynamic scheduling of tasks to cores with a goal of achieving extreme energy efficiency. Additionally, hardware delay and performance monitors will be embedded in logic so that the process variability can be controlled through immediate dynamic reconfiguration.  The greatest benefits will accrue from recognizing the optimization opportunities that the individual research ideas enable across the software/architecture/circuits stack. The applicant will not only acquire multidisciplinary training through the execution o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'iTANK: a nuniversal technology to boost the efficacy of CAR T cell therapies by inducing dual mode-of-actio' (CD20CARNAPT).

assistant: **Innovation**

Elicera developed a universally compatible technology platform called iTANK (ImmunoTherapies Activated with NAP for efficient Killing) to enhance the efficacy of current and under development CAR-T cell therapies by inducing a dual mechanism-of-action in the treatment of lymphomas and solid tumours. Elicera’s iTANK platform can circumvent major challenges of CAR-T cells in the treatment of solid tumours, such as antigen heterogenicity, local immunosuppression, and CAR T-cell exhaustion.  As such, the iTANK platform has a potential to revolutionise the landscape of the immuno-oncologyOur innovation arms CAR-T cells with NAP from H.pylori which induces a pro-inflammatory microenvironment and activates the patient’s own CD8+ killer T-cells against the whole repertoire of relevant tumour antigen targets. When tumour cells are killed, NAP-activated dendritic cells can take up tumour-associated antigens and prime killer T-cells against these antigens overcoming problems for CAR-T therapy.


**Keywords:** dual anticancer action,genetic modification,T cells,immunomodulation,B-Cell lymphoma,NHL,CAR T-cell therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Network on thermal barrier coatings' (1994-1998).

assistant: **Concept**

Given the constant drives to improve component efficiencies, to reduce fuel usage and to lessen the environmental impact, thermal barrier coatings have become increasingly important to a wide range of industrial sectors associated with advanced transport and advanced power generation. This lead to a recent increase in research and development activities, in particular in Europe, associated with TBC use in turbines and diesel engines. It is to be reckoned though that in front of this complex and multidisciplinary problem, the approaches from the industry-supported-side, have been largely empirical in nature and application specHic. Moreover scientific knowledge on most important issues is still incomplete and when it exists, not always accessible to industry. A need therefore exists, and this proposed network aims at fulfilling it: - to assess the state of TBC knowledge, addressing the diverse aspects (physical, mechanical and chemical properties, failure mechanisms, lifing etc) and identify critical gaps that hinder use in advanced applications, - to provide a forum for exchanging scientific and technological information derived from on-going research projects, - to promote cooperative scientific and technological research, in particular through staff and student placements in members laboratories. The specific goals of this exploratory phase will be: - to establish a database of on-going research through contacts with project coordinators - to build up a network of national coordinators. - to establish a memorandum of understanding defining the conditions for collaboration within the network and have it accepted by a minimum number of participants - to propose a work package outlining the technical programme including workshops, staff mobility, student placement during
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Novel and Affordable Multi-Fidelity Deep Neural Network Uncertainty Quantification/Robust Optimization Design Framework for Industrial Turbomachinery' to be submitted under Horizon 2020.

assistant: **Abstract**

This fellowship aims to train a talented early career researcher and to contribute to the EU scientific excellence by developing an innovative Multi-fidelity dEep neural Network uncerTainty quantificatiOn and Robust optimization design (MENTOR) framework in order to handle the high dimensionality (HD) uncertain problems in the advanced multistage turbomachinery design process. The applicant is a highly dedicated and motivated young researcher and has been stimulated to propose this novel idea. He has been successively honoured with several prestigious awards including the National Scholarship for PhD Candidate, Excellent PhD Graduates of Beijing, Excellent Doctoral Dissertations Award of Beijing and ASME Young Engineer Turbo Expo Travel Award attributed to his excellent research achievement in cost-efficient uncertainty quantification (UQ) studies. The traditional UQ methods can hardly control the computation cost for predicting the higher-order moments of multistage turbomachinery performance considering HD input uncertainties. The deep learning technology is a promising approximator in predicting the HD function. Integration of multi-fidelity (MF) methodology with deep neural network (DNN) can further combine their complementary merits. Thus, the novel MF-DNN method is proposed here and its effectiveness in handling a 60-dimensional test function has been preliminarily validated in the Incoming Researcher's recent work. Through this research fellowship, an affordable MENTOR framework will be finally established to investigate the multi-source uncertainty effects on multistage turbomachinery performance. This project has been carefully designed to match the applicant's profile with the strength of Imperial's UQ Lab, and thus will facilitate excellent two-way knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Age of Civil Wars in Europe, c. 1914-1949' to be submitted under Horizon Europe.

assistant: **Abstract**

In the first half of the twentieth century, Europe experienced an unparalleled number of civil wars resulting in millions of deaths. Civil war, as much as inter-state war, was a defining feature of the period for many European societies, from Ireland in the west and Russia in the east, to Finland in the north and Spain and Greece in the south. Since the 1990s, a rich and increasingly sophisticated body of literature has emerged on individual incidents of civil war, ranging from military studies to social and cultural analyses. However, remarkably little comparative work has been undertaken on civil wars in this period. Even fewer studies have explored the connections between them – be it transfers of people, ideas, or practices – beyond their ideological tropes. This has resulted in a tacit assumption of exceptionalism, whereby each civil war is assumed to have been unique and self-perpetuating without any serious attempt to explain why that was so. This project challenges exceptionalist approaches to civil war. While it recognises that significant differences in causes, forms, and/or aftermaths existed between individual civil wars, it argues that those civil wars can only be fully understood as a phenomenon within a pan-European context.  The project will therefore investigate the origins, courses, and legacies of European civil wars through a fully integrated team of scholars with complementary expertise on the Russian, Finnish, Irish, Spanish and Greek cases. This will enable comparison between these different conflicts, but it will also go beyond the nation-centric tendencies of comparative approaches to arrive at a better understanding of what made the first half of the twentieth century an era of civil wars in Europe.


**Keywords:** history of violence,  history