RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Interplay of epithelial mechanics and neutrophil activation as a pathomechanism in refractory IBD and colorectal cancer patients' (INTERCONNECTIONS), addressing dissemination and exploitation.

assistant: **Impact**

Inflammatory bowel diseases (IBD) are a heterogeneous group of disorders characterized by gastrointestinal tract inflammation, being Crohn's Disease and Ulcerative Colitis, the most clinically abundant. IBD affects around 6.8 million people all over the world, being Europe the continent with the highest prevalence. Although anti-TNF-α monoclonal antibodies are a breakthrough therapy, almost 40% of IBD patients do not respond to therapy or acquire resistance. This leads to uncontrolled inflammation that, prolonged in time, constitutes a higher Colorectal Cancer risk. This justifies the current efforts to identify innovative therapy targets for IBD understanding of the molecular processes behind (personalized medicine). The fact that an increased intestinal permeability precedes the onset of inflammation possesses epithelial disruption as a potential etiological factor in IBD. Moreover, in recent years, several publications have highlighted that an impaired epithelial barrier is linked to resistance to therapy. Nevertheless, how altered epithelial mechanics can influence the structural properties of the extracellular matrix and immune cells migrating through it is not fully understood. On the other hand, the role of neutrophils as resistance-to-therapy players has emerged very recently. Then, we hypothesize that an alteration in epithelial cell mechanics constitutes a primary event that impacts the proliferation and behavior of the first immune cell responders: neutrophils. This would further contribute to ECM remodeling and fibroblasts polarization to IAFs (another mechanism implicated in therapy resistance). Then, INTERCONNECTIONS aims to elucidate how an altered epithelial dynamics constitutes a primary event that directly (through an altered transepithelial migration)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Histidine Phosphorylation and Obesity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Histidine PhosPhorylation and Obesity  Protein histidine phosphorylation is a poorly characterized post-translational modification. Its importance in mammalian cellular function is emerging from the discovery of histidine kinases and phosphatases and their substrates. Recently, histidine phosphorylation has been involved in heart failure and cancer. Obesity and type 2 diabetes remain challenging disorders due to growing prevalence around the world and poorly efficient treatments. Regarding metabolic disorders, histidine phosphorylation state has been associated with insulin secretion regulation in pancreas. However, the role of histidine phosphorylation in insulin sensitivity in liver, skeletal muscle or adipose tissue and/or in obesity is still not known. The main aim of the present project is to determine whether protein histidine phosphorylation plays a role in obesity-associated metabolic dysfunction. Thus, we will determine if obesity modify global histidine phosphorylation level, histidine kinases and phosphatases expression or activity, and specific protein histidine phosphorylation. Then, we will evaluate whether a change of histidine phosphorylation level can impact whole-body glucose metabolism and body weight/composition by using transgenic mice deficient in histidine phosphatases and/or kinases.


**Keywords:** Obesity, Insulin resistance, Diabetes, Histidine phosphorylation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Silicon-based Nanodevices', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

SINANO aims to strengthen European scientific and technological excellence in the field of electronic, Si-based nanodevices for terascale integrated circuits. Over the next quarter century considerable challenges exist to push the limits of silicon integration down to nanometric dimensions. These can best be addressed by integration, at the European level, of the individually excellent research capabilities already existing in the main university and national research centres. SINANO's activities, with long-term and multidisciplinary objectives, could herald a revolution in 1C technology, involving integration of nanoscale CMOS and emerging post-CMOS logic and memory devices. SINANO will work to enhance device performance and integration, to meet the ever- increasing demands of communications and computing.The network includes partners with expertise required to develop these advanced devices, from basic materials science through design and fabrication to characterisation and device modelling. This ambitious programme will make Europe the world-leading centre for nanoelectronic devices - from fundamentals through to realisation, advancing this crucial technology to underpin the European economy over the coming decades.The proposed Joint Programme of Activities includes significant integrating activities: coordination of the partners' activities leading to the extension of specialisation, a joint technical research programme, sharing Joint Research Platforms for Processing and Characterisation, management of knowledge, staff exchanges, electronic communication (e-mail, conferencing, website), activities to spread excellence (training researchers, students and technical staff, dissemination of results by open European Workshops). It will be orchestrated by a unified manag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Personal software process in numerical control production environment'.

assistant: **Objectives**

The critical factor in producing NCs is definitely the software. For our business we need: More reliable software, less time dedicated to the software maintenance, reduced time to market, better prediction of the time to market.THE EXPERIMENTA significant improvement in software quality is only possible if each software engineer really wants to achieve it.ISO 9000 or other organisational rules are frequently applied in stereotyped way, thus reducing and even vanishing the possible benefits. Each software engineer should be in a kind of competition with himself and his previous results. Each software engineer should be motivated to use a disciplined personal process, partially defined by himself and fitting his needs. The Personal Software Process (PSP), defined by Watts Humphrey (of the Software Engineering Institute at the Carnegie Mellon University) in his recent book A Discipline for Software Engineering" takes precisely this point of view. This experiment aims at introducing the PSP in the companyEXPECTED IMPACT AND EXPERIENCEThe main objectives are: Number of faults per Mloc, reduced to 25%. Maintenance effort, reduced to the 10% of the total development effort. Productivity, 25% improvement. More accurate prediction of the projects planned duration (<1,2). Improved motivation of the staff."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Alternative fuels for industrial gas turbines - (AFTUR)' (AFTUR), addressing dissemination and exploitation.

assistant: **Impact**

This project aims to contribute to the optimisation of alternative fuel powered industrial gas turbines for heat and power generation. The project will deliver the methodologies required to develop IGTs capable to operate on a wide range of alternative fuels. The use of liquid and gaseous fuels from biomass will help fulfil the Kyoto targets concerning GHG emissions. Waste gases from industrial processes will be evaluated as a potential gas turbine fuel. The project aims to assess the combustion performances of these new fuels for clean and efficient energy production by gas turbines. Another objective is to extend the capability of dry low emission gas turbine technologies to low heat value fuels produced by gasification of biomass (LHV < 25% natural gas) and H2 enriched fuels. As a whole the project will contribute to the aspirations of EU energy policy in harmony with the White paper on RES and the Green paper on the security of energy supply.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Next Generation Internet of Things' (NGIoT).

assistant: **Concept**

NGIoT is a Coordination and Support Action (CSA) that will create a robust and agile research, innovation and implementation agenda that will lead to unlocking the growth potential of the Internet of Things (IoT) while respecting core European values, supporting key EU policies, leveraging the key associations, and establishing a Strategy Board. The main objective of NGIoT is to mobilise effectively and provide strategic coordination of existing IoT-related stakeholders, organisations, networks, initiatives and projects in preparation of upcoming key European and national industry and research and innovation as well as implementation initiatives. NGIoT establishes a roadmap for European Internet of Things (IoT) research and innovation as well as implementation that addresses the complex situation of IoT in the world today.  Furthermore, it shows a way forward based on European values, and it supports key policies such as the Digitizing European Industry (DEI) and the Digital Single Market (DSM) situating IoT in relation to the rest of the technology landscape, including security, Artificial Intelligence (AI), 5G, edge computing, and not least the Next Generation Internet (NGI). The NGIoT ambition reflects a realization that the landscape for deploying human-centred IoT is very dynamic, multi-sectored and multi-faceted, calling for an inclusive and innovative approach to research and innovation. In addition, the NGIoT ambition calls for an implementation strategy and orchestration that can inform and be informed by societal needs, including the need to formulate policy, to create standards and to give guidance on technical feasibility at scale across application domains. The three-year action will interconnect prominent stakeholders and initiatives in the field of IoT in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A new integrated process to valorise hazardous leaded glass from CRTs and transform it into high performance geopolymer blocks - VirtuCrete'.

assistant: **Concept**

The world is sitting on a ‘CRT mountain’; For TVs and monitors, Cathode Ray Tubes have been the main screen technology,up until the revolutionary change to LCD and plasma screens that has recently taken place. Consequently, the current CRTpopulation (1.9 billion screens; 500 million of them in Europe) is becoming obsolete and will require processing (not landfill)according to WEEE regulations, since the high proportion of lead in the glass means that landfills have an unacceptable riskof lead leaching into groundwater. The very low manufacturing rates for new CRT worldwide now mean that recycling theglass back into CRTs is no longer an option, and the only alternatives to avoid landfill have been to use the glass as asmelting flux (85% of it remains as a toxic slag), or using foundry temperatures (1000°C) melt extraction for the lead, whichis extremely energy and CO2 costly, and at best produces an 80% co-stream of low value glass.Our idea is to process leaded CRT glass using a novel hydrochemistry method to precipitate out the lead, which can be sold.The residual output stream from our VirtuCrete process contains an alumino-silicate mix that can be used as an alternativeto Ordinary Portland Cement (OPC), to produce a high-silica concrete geopolymer block. This new material has exceptionalresistance to salt, acids and water, making it suitable harsh conditions and flood defences, and high temperature resistance(over 1200°C) making it applicable to fire risk applications such as road tunnels or waste storage segregation. The novelchemistry also allows use of recycled aggregate, potentially reducing the cost of our geoblocks by 50% compared to OPCblocks. The new technology could enable EU waste recyclers and concrete block producers to co-operate to solve the CRTproblem a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'wireless Body Area Networks for high density MYOelectric neurorehabilitation technologies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The next generation of rehabilitation systems will require the evaluation and restoration of the motor impairment using neural information. For this purpose, noninvasive multichannel electromiographic (EMG) technologies are the most promising tools for research and clinical neurorehabilitation applications. Unfortunately, the current systems for high-density (HD) EMG recordings require long cables that impose significant restrictions on the patients and limit free movement. Moreover, the integration of such bulky systems into current rehabilitative exoskeletons may be problematic. For these reasons, the project MyoBan aims to develop an innovative portable HD EMG system based on recent standards designed for the next generation of wireless body area networks. The proposed system will exploit the spatial and temporal characteristics of the surface EMG signals to reduce the data-rate and optimize transmission parameters (e.g. transmitting power, specific absorption rate, real-time processing, etc.). The final aim will be the production of small HD EMG sensors that can be placed on the surface of multiple muscles of the patients with minimal invasiveness and high efficiency. The project will combine expertise in several fields: telecommunication, biomedical signal processing, medical information technologies and neurorehabilitation. The MyoBan is expected to produce substantial progress in the research and clinical applications of neurorehabilitation technologies for motor restoration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Strengthening the OAPEN infrastructure in support of European Union Open Access policy' (OAPEN-EU) targeting Horizon Europe.

assistant: **Abstract**

Monographs and other forms of academic books remain integral to scholarly output and the communication of research, particularly within the social sciences and humanities (SSH). Developing a culture of Open Science within the European Research Area (ERA), in alignment with the Council conclusions on high-quality, transparent, open, trustworthy, and equitable scholarly publishing (May 2023), must therefore encompass open access (OA) to scholarly books. In the Annotated Grant Agreement of the EU Funding Programme 2021-2027 this is clearly addressed: “The beneficiaries must ensure open access to peer-reviewed scientific publications relating to their results.”  whereas the term ‘publications’ include both journal articles and books.This project directly addresses the EU’s Open Access policy requirements by strengthening the OAPEN Library, a critical infrastructure for curating, hosting, disseminating, and preserving peer-reviewed long-form publications, i.e. scholarly books (monographs, edited collections etc.) and book chapters. By enhancing services tailored to the specific needs of Horizon Europe-funded books, the project supports the open access mandates of the European Commission and the European Research Council under Horizon Europe and contributes to the EU’s broader Open Science framework.


**Keywords:** open access books, infrastructure, funder collections, monitoring, Horizon Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of three-dimensional genome architecture on innovation through gene duplication in chordates' (CHORDUP).

assistant: **Concept**

Inside the nucleus of each eukaryotic cell, DNA is intricately packed into a three-dimensional (3D) structure essential for gene regulation. However, its role in genome evolution, particularly in gene function innovation, remains largely unexplored. Gene duplication is the primary evolutionary path to gene function innovation. This project aims to investigate the interplay between gene duplication evolution and 3D genome structure in chordate genomes by comparing zebrafish to amphioxus, a non-vertebrate marine chordate that diverged from the rest of chordates about 500 million years ago. By generating, for the first time, 3D genome structure maps for several amphioxus organs, I will construct an atlas of gene duplications in zebrafish and amphioxus, encompassing sequence, synteny, gene expression, and 3D genome structure information. Leveraging the information encompassed in this atlas, I will investigate the intricate dynamics between the origin and evolutionary fate of chordate duplicated genes, emerged either by whole-genome or small-scale duplication, and the 3D genome structure around them. By combining my expertise in evolution of gene duplications and amphioxus genomics, with my host group’s experience in 3D genomic architecture and its evolution, we will be able to provide deep insight into the spatial mechanisms of gene innovation through duplication. Studying the effect of 3D genome structure across amphioxus and zebrafish organs in the context of gene duplications, will position me at the forefront of this emerging field within the comparative genomics community. Altogether, the results obtained will enhance our understanding of the evolution of new gene functions, and open new avenues for structural and evolutionary genomics.


**Keywords:** 3D genome struct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Probiotic strains with designed health properties' (DEPROHEALTH) targeting Fifth Framework.

assistant: **Abstract**

The Lactic Acid Bacteria (LAB) is well known for their extensive use in the preparation of fermented food products. In addition, the potential health benefit they may exert in humans has been intensively investigated during the last century. However, the mechanisms underlying the health promoting traits attributed to LAB, especially lactobacilli, remain vastly unknown which has impaired the rational design of robotic screening methods with accurate predictive value. As the probioticarea corresponds to a rapidly expanding market, the DEPROHEALTH project first aims at establishing a correlation between inviter tests and mouse models mimicking important human intestinal disorders such as Inflammatory Bowel Disease, Helicobacter pylori and Rotavirus infections. As these diseases correspond to major public health problems, second generation probioticstrains with enhanced prophylactic or therapeutic properties will also be designed during the project. These designed strains and the isogonics parental ones will be used to unravel mechanisms involved in the immunomodulation capacity of specific Lactobacillus strains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Improving laser welding in automated manufacturing'.

assistant: **Innovation**

The Car industry has been constantly improving and expanding its manufacturing and assembly processes in the last two decades. Due to this development the end- products have considerably improved in terms of comfort and safety. These improvements have lead to an increase in sales, but no comparable increase in employment has been yet observed. One reason for this development is that a lot of newer technologies employed in the manufacturing process require more attention and care than previous manufacturing methods. This project will be a RTD project whose key goal is to develop/improve a new, generation of machinery, production equipment and systems for manufacturing. This answers the targeted research action call on machines of the Growth program. The exploitation of the results can be expected as soon as 3 months following the completion of the project period since the results will be used in industrial production.