RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding Diagnosing and Early intervention in the Myeloid malignancy Continuum' (UDEMC).

assistant: **Concept**

As humans age, Hematopoietic Stem and Progenitor Cells (HSPCs) accumulate preleukemic mutations (pLMs), forming preleukemic HSPCs (preL-HSPCs) and leading to clonal hematopoiesis (CH). While the link between CH and myeloid malignancies is established, predicting progression remains elusive. The Shlush lab aims to enhance myeloid malignancies outcomes through early diagnosis and treatment. Still, it faces three gaps: 1) lacking advanced tools for diagnosis/risk stratification beyond mutations, 2) insufficient understanding of pLMs functional consequences, and 3) absence of targeted therapies against pLMs.To address these challenges, our proposed specific aims are as follows:Aim 1: Develop a novel diagnostic tool for myeloid leukemia using single-cell RNA sequencing (scRNAseq) of peripheral blood HSPCs from 1300 patients and replace bone marrow (BM) analysis in the future. Such a cohort will allow the discovery of novel mechanisms in leukemia and improved diagnostics. Aim 2: Create an in vitro assay to explore molecular and functional consequences of human pLMs at the single-cell level, considering self-renewal and changing microenvironments. Aim 3: Identify drugs targeting human preleukemic HSPCs through a high-throughput drug screen of human preL-HSPCs. This novel approach aims to pave the way for targeted early interventions.To make these goals feasible the Shlush lab made three major steps forward: 1) created the first reference map of peripheral blood (PB) HSPCs from 150 healthy individuals. 2) developed a dynamics bone marrow in a dish allowing the study of human preL-HSPCs. 3) developed the apoptosis score for detecting apoptosis in a small number of preL-HSPCs.


**Keywords:** clonal hematopoiesis, preleukemic mutations, drug screen, single cell RNA sequencing, my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Key Exploration of intermolecular Bonding in chiral recognition using Advanced laser light Beams' in the context of a Horizon Europe call.

assistant: **Objectives**

Chiral recognition is the ability of a chiral molecule to discriminate between the two enantiomeric forms of another chiral molecule. An important question is how do intermolecular interactions contribute to high enantioselectivity in several natural and synthetic processes that are key in biochemistry, asymmetric drug and polymer synthesis and analytical chemistry, for example. This enantioselectivity results from thermodynamic and kinetic considerations, but little is known about the dynamic nature of intermolecular interactions at the molecular level. Capturing the time evolution of chiral recognition requires laser imaging techniques that can trace atomic and electronic motions at the few femtosecond (10-15 s) timescale, both of which are essential for understanding chemical bonding. However, there is a lack of laser-driven technologies capable of directly measuring intermolecular chiral dynamics with sufficient time resolution and sensitivity.The objective of KEBAB is the investigation of chiral recognition between chiral molecules in real-time, enabled by the development of next-generation ultrafast light sources to be combined with experimental methods that are highly sensitive to chirality.Pressing questions about the dynamic evolution of chiral recognition will be answered such as: i) what are the mechanisms which allow chiral molecules to dynamically recognize each other? ii) how does a molecule transfer chirality to an achiral molecule? and iii) can we use electronic currents as chiral-sensitive forces on the nuclei to influence the enantioselectivity of the interactions in chiral recognition? KEBAB will provide a deep understanding on the dynamics influencing chiral recognition and on how the joint electron and nuclear motion at ultrafast timescales can be e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Benznidazol and Triazol REsearch group for Nanomedicine and Innovation on Chagas diseasE' (BERENICE) targeting Seventh Framework.

assistant: **Abstract**

The BERENICE consortium is aiming at providing a new and cost-effective solution to a better treatment for Chagas chronic patients. Please see its objectives below :Main objective• Obtain a more effective, better tolerated and cheaper formulation of a drug with trypanocidal activity to cure Chagas diseaseSpecific Objectives• Obtain results of pharmacokinetics of new formulations• Assess trypanocidal activity of new formulations in vitro and in animal model• Involve partners, research and industry in endemic countries to promote technology transfer and promote in-site solutions at cheaper cost.The foreseen results of this project would have firstly an impact on the better comprehension and control of the SUVs behavior as drug delivery nanodevices for the specific APIs to be conjugated. If this conjugation is successful, further impacts are expected dealing with technology transfer issues, such as scale-up of the corresponding SUVs preparation methodology and its implementation at industrial scale.Apart from including stong participation from endemic countries's institutions, the consortium also involves private companies, thus enabling the participation of all the key actors of the chain to confront and control better Chagas disease. The innovative approach, through the new developed nano- and microparticles based formulations will have an important impact on the safety of the medicament since the therapeutic efficacy will increase and consequently the doses needed and the incidences caused by adverse effects will be reduced.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Ultra-Scalable and Ultra-Efficient Integrated and Visual Big Data Analytics'.

assistant: **Innovation**

LeanBigData aims at addressing three open challenges in big data analytics: 1) The cost, in terms of resources, of scaling big data analytics for streaming and static data sources; 2) The lack of integration of existing big data management technologies and their high response time; 3) The insufficient end-user support leading to extremely lengthy big data analysis cycles. LeanBigData will address these challenges by:Architecting and developing three resource-efficient Big Data management systems typically involved in Big Data processing: a novel transactional NoSQL key-value data store, a distributed complex event processing (CEP) system, and a distributed SQL query engine. We will achieve at least one order of magnitude in efficiency by removing overheads at all levels of the big-data analytics stack and we will take into account technology trends in multicore technologies and non-volatile memories. Providing an integrated big data platform with these three main technologies used for big data, NoSQL, SQL, and Streaming/CEP that will improve response time for unified analytics over multiple sources and large amounts of data avoiding the inefficiencies and delays introduced by existing extract-transfer-load approaches. To achieve this we will use fine-grain intra-query and intra-operator parallelism that will lead to sub-second response times.Supporting an end-to-end big data analytics solution removing the four main sources of delays in data analysis cycles by using: 1) automated discovery of anomalies and root cause analysis; 2) incremental visualization of long analytical queries; 3) drag-and-drop declarative composition of visualizations; and 4) efficient manipulation of visualizations through hand gestures over 3D/holographic views.Finally, LeanBigData will demon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Secured Collaboration Platform for Law Enforcement and First Responders', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

All security forces are facing the following same three challenges when dealing in emergency situations and scenarios: 1) reliable (and secured) communication (intra-team); 2) effective collaboration (inter-team); 3) visibility of personnel (especially inside buildings). These challenges affect Military & Defence; Law Enforcement; First Responders; and Private Security (Executive Protection, Campus Security, and Guarded Communities).An encrypted communication platform centred around an intuitive collaboration interface, GlobeKeeper’s technology utilises standard equipment to create a secure, end-to-end solution that keeps security personnel safe, reduces costs, and enhances decision making capabilities. GlobeKeeper enables users to transmit live video and streaming, share files, text messages and pictures – all in real time and in a secure environment while using the existing smart devices (iPhones, Androids and tablets that they already have).In a nutshell, GlobeKeeper want to be the Slack  application for security personnel, creating new radios. As such, it harnesses the most advanced encryption and exchange protocols in the industry. By integrating existing hardware, cameras, GPS devices, and other Bluetooth-enabled hardware with secure communication protocols, GlobeKeeper’s system transforms them into essential resources for mission operations, case management, and resource control. GlobeKeeper is in a league of its own, creating and providing a product that none of its closest competitors are selling presently. GlobeKeeper is the only solution that supports ‘offline environments. GlobeKeeper finished 2018 with 5 customers, ~$1M in bookings and intends to scale to 14+ accounts and $2.5M in sales by Q1 2020.  In this respect it should be highlighted that the Europol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Communities of Tacit Knowledge: Architecture and its Ways of Knowing' to be submitted under Horizon 2020.

assistant: **Abstract**

The 'Communities of Tacit Knowledge' (TACK) ITN will focus on the concept of ‘tacit knowledge’ in architecture. Tacit knowledge is a specific type of knowledge that architects employ when designing, which is also embodied in the material vectors that they design with; from treatises and drawings to models and buildings. This ITN will train young researchers in the development of advanced theoretical frameworks and specialized methods for the analysis of the specific knowledge used by architects while designing buildings and cities. It focuses on the characteristics, the dissemination and the heuristic potential of this knowledge that is particular to architectural design practice. Structured around three training axes: (1) Approaching Tacit Knowledge: Identifying Methods and Histories, (2) Probing Tacit Knowledge: Concrete Cases and Approaches and (3) Situating Tacit Knowledge: Concepts and Theories, the TACK ITN for the first time combines the expertise on tacit knowledge that has been developed at ten different research centres in Europe. Together with three cultural and three practice-based partners, these ten research centres will train a group of scholars to explore and conceptualize the very character of tacit knowledge to better understand its possible roles in addressing new and pressing issues in the built environment from alternative vantage points. This powerful combination of expertise from industry and academia, will introduce these ESRs to new heuristic methods and add to their inter-sectoral employability. Implementation of the TACK ITN will result in ten PhDs, three online training modules, an international colloquium, a major exhibition, a lecture- and debate series, a synthetic reader, a book, and a website providing public access to research results a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The (re)construction and formatting of religions in the West through courts, social practices, public discourse and transnational institutions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

RELIGIOWEST is an interdisciplinary endeavour to bring together legal, sociological and political insights in the study of religion in the West. It aims at studying : 1) how different western states (in Europe and North America) are redefining their relationship to religions, under the challenge of increasing religious activism in the public sphere, associated with the spread of new religious movements (evangelicalism, cults) and Islam, 2) how this process mobilizes a complex array of often unrelated actors: courts, administrations, business milieus, but also practicing believers who want to be recognized both as citizens and members of a faith community, public opinion eager to curb what is perceived as “foreign” or “extremist” expressions of religion, politicians navigating between political correctness and populism, and “external” actors, like the US government, the European Court of Human Rights and transnational organizations (the Catholic church, the Muslim Brotherhood), 3) how this process is gradually producing a new and common paradigm of the relationship between states, the public sphere and religion, contributing paradoxically to European integration.We intend to make field-works in 12 countries, both in North-America and Europe, adding Turkey. After studying the specific national legal frameworks dealing with religion in public sphere, we intend to analyse the potential convergences in framing a new common paradigm of the place of religion in the public sphere. The project aims at providing tools for a common European policy implementation on religion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Demonstration of Energy Efficient and Environmental Friendly Heat Pumping System Using Co(2) as Working Fluid'.

assistant: **Concept**

The main objectives of the V project are to demonstrate functionality of CO2 heat pumps systems for hot water supply, space heating and drying process and to introduce such systems into the market. µ This project also aims to save energy and to reduce the greenhouse gas emissions caused by heat pumps running with conventional refrigeratnts and conventional heating systems and to resolve current European and world wide concerns regarding carbon-dioxide as a working fluid in heat pumps The project will address the following key European societal needs: Demonstrating the energetic efficiency and the cost effictiveness of heat pumps using the advantages of carbon-dioxide as a refrigeraatnt, ensuring and increasing the competitiveness of the European heat pump industry and contributing to minimising the direct (refrigerant losses) and indirect (CO2 emissions caused by burning fossil fuels for providing energy) effects pf heats pumps to the global warming problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Technical ceramics machining using traditional machines to remove chips with the help of the laser technology' (1994-1998).

assistant: **Concept**

The present study aims at studying a new machining process of technical ceramics by using a traditional CNC machining lathe. A Nd-YAG or diode laser will be integrated to this lathe for the preheating of the material (A1203, ZrO2, A17r, Mullite) to bring it to a state of plasticity. The ceramics machining by chips removal should give machining results of about 20 to 30% higher with an increase of the mechanical properties of the finished part. Emphasis will be put on the process control to guarantee the obtention of the final machining dimension while taking into account the thermal expansion of the material due to the laser heating. A prototype of the machining machine including a laser beam handling system of 5 free degrees and guaranting a good tests reproducibility will be made by IREPA LASER At the same time a process control system will be finalized by FHG-IPT to adjust to the depth of pass of the tool according to the material expansion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The MareNostrum Experimental Exascale Platform' (MEEP).

assistant: **Innovation**

The MareNostrum Experimental Exascale Platform (MEEP) is a flexible FPGA-based emulation platform that will explore hardware/software co-designs for Exascale Supercomputers and other hardware targets, based on European-developed IP. MEEP provides two very important functions: 1) An evaluation platform of pre-silicon IP and ideas, at speed and scale and 2) A software development and experimentation platform to enable software readiness for new hardware.  MEEP enables software development, accelerating software maturity, compared to the limitations of software simulation. IP can be tested and validated before moving to silicon, saving time and money.The objectives of MEEP are to leverage and extend projects like EPI and the POP2 CoE in the following ways:● Define, develop, and deploy an FPGA-based emulation platform targeting European-based Exascale Supercomputer RISC-V-based IP development, especially hardware/software co-design.● Develop a base FPGA shell that provides memory and I/O connectivity to the host CPU and other FPGAs.● Build FPGA tools and support to map enhanced EPI and MEEP IP into the FPGA core, validating and demonstrating European IP.● Develop the software toolchain (compiler, debugger, profiler, OS, and drivers) for RISC-V based accelerators to enable application development and porting.MEEP will deliver a series of Open-Source IPs, when possible, that can be used for academic purposes and integrated into a functional accelerator or cores for traditional and emerging HPC applications. This is an exciting target for IPs generated from projects like EPI, and an IP source for follow-on projects as well. MEEP will provide a foundation for building European-based chips and infrastructure to enable rapid prototyping using a library of IPs and a standard set o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Boosting Telematics Programme Dissemination'.

assistant: **Innovation**

The purpose of PIPER is to back EU Telematics applications Programme project dissemination activity. Guidelines on how project reports should be formatted for easy inclusion on WWW servers and CD Rom, and a tool kit for a consistent indexing and cross referencing system for processed items are two central features. The material processed and disseminated will constitute a valuable source of information on the all-round progress of projects. A market-driven project in a fast-moving field, PIPER will seek feedback on guidelines and tools which will be in three versions to reflect fully the current state of the art.The objective of PIPER is to deliver dissemination support for projects in the Telematics Application Programme. The main outputs from the project will be:- guidelines which describe how projects should format their reports so that they can be easily processed for inclusion on WWW servers and CD Rom- a tool kit made available to all programme participants which will be used to generate a consistent indexing and cross referencing system for the processed deliverables- a service which will take as its input documents produced by the projects and process them for inclusion on the selected medium.By providing both the service and the tools to process deliverables the PIPER project will result in up to 500 deliverables being processed and widely disseminated. In combination these will form a valuable source of information on the progress of the various telematics projects.PIPER will be a market driven project operating in a fast changing area. For this reason the project will work closely with the Telematics Applications Programme and maintain liaisons with the projects. It will actively seek feedback on the guidelines and the tools to be developed. In order to ensur