RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional cOmposition of post quantum Cryptosystems At Large' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The FOCAL project will deliver a unified framework to achieve practical E2E functional composition of PQC in edge networked environments. Functional composition will be accommodated under a cross-layering paradigm mapping requirements of existing PQC cryptosystems and further improving them through appropriate methodologies and mechanisms via considering device, software, networking and communication properties. Consequently, FOCAL will act as a cornerstone on achieving the first practical and programmable composition of PQC across the full E2E path between a given datacenter orchestrating cloud services to an edge deployment. This will be achieved through (i) crypto-agility via hardware reconfigurability , (ii) exploitation of communication channel properties on the edge, (iii) network instrumentation and orchestration via advanced software-defined technologies, (iv) enhanced PQC key generation, encapsulation and storage underpinned by hardware acceleration schemes, (v) lightweight synthesis of distributed Trusted Execution Environments (TEEs) amongst edge devices, and (vi) awareness of application-level interoperability requirements inferred through Machine Learning (ML)-driven edge device learning. The envisaged technical directions will be dictated by non-technical activities encapsulated within the FOCAL framework assessing metrics associated to measuring the transition of such edge-oriented ecosystems into PQC and on improving existing standards and policies through lessons learned. Thus, contributing significantly towards the EU objectives and guidelines as outlined in the EU Commission Recommendation on Post-Quantum Cryptography.


**Keywords:** hardware, adaptability, crypto, agility, PQC, network, instrumentation, orchestration, TEE, interoperable, protocols,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'LUMES  LUng cancer Metastasis Evolutionary Studies' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Metastatic disease, describing the development of secondary malignant growths at a distance from a primary site of cancer, is associated with over 90% of cancer-related deaths. There exists a significant unmet clinical need to better understand the biology of aggressive cancers leading to metastatic disease and the underlying mechanisms that can facilitate the metastasis. Previous studies exploring metastasis have suffered from scarcity of samples, insufficient resolution and breadth of experimental data, and a lack of appropriate computational and statistical tools. These inadequacies have led to significant ambiguities in data interpretation resulting in a substantial knowledge gap, hindering translational opportunities to tackle metastatic disease. LUMES will provide crucial contributions towards an in-depth understanding of metastasis by (1) exploiting access to the singular Posthumous Evaluation of Advanced Cancer Environment (PEACE;  NCT03004755) research autopsy programme with extensive sampling from both primary and metastatic sites to generate a unique resource for exploration of metastatic cancer evolution, (2) applying cutting-edge experimental techniques to human samples, (3) developing advanced novel AI enhanced computational and statistical tools designed to study metastasis and metastatic spread, (4) applying an integrative view of cancer development, incorporating genetic and non-genetic analysis of cancer-cell intrinsic and extrinsic features as well as ctDNA, in the context of the tumour microenvironment and detailed clinical annotation, including exposure to cancer therapies. Importantly, (1) and (2) provide an indispensable fundament for (3) and (4). The synergies between (3) and (4) are immense. Computational method development and application shoul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Burden of Adult Mortality in India: Socioeconomic Inequality and Impact on Household Wellbeing'.

assistant: **Objectives**

The record of vital events such as births and deaths are the most critical social statistics that have been increasingly used for monitoring social and health development. Most developing countries do not have a complete and robust vital registration system, leading to a lack of mortality data. Therefore, a rigorous assessment of adult mortality and disparities is limited. The research project: AMI: SEI (Burden of Adult Mortality in India: Socioeconomic Inequality and Impact on Household Wellbeing) as a case study of India aims to investigate adult mortality in order to fill in knowledge gaps and strengthen evidence-based policies for tackling potentially avoidable adult deaths at working ages (15-59 years). Rising deaths due to non-communicable chronic diseases and violent deaths such as traffic accidents and suicides pose new challenges for sustainable health progress in Low-middle income countries (LMICs). These emerging health threats primarily affect disadvantaged population groups with lower socioeconomic status. Therefore, this project focuses on adult mortality by socio- economic characteristics from a demographic and public health perspective. First, the proposed study will explore regional inequality in adult mortality by gender across the different Indian regions during 1990-2023 and impact of COVID-19 in 2020-21 on adult mortality. Second, a systematic assessment of adult mortality disparities by socio- economic group will be conducted in order to identify commonalities and differences in the magnitude and patterns of disparities in India. Finally, the economic impact of potentially avoidable adult deaths on the well-being of households will be examined. The expected scientific outcomes of this project will provide new policy-relevant knowledge about adult m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Lassie: The first-ever painless breath analyser for people with diabetes, a breakthrough in blood glucose monitoring' (Lassie).

assistant: **Concept**

Today, dogs are used to detect high and low blood glucose, cancers and are tested for coronavirus.The new Lassie breath analyser BOYDSense will put the power of a dogs nose into peoples hands and give them access to gentle health monitoring.Lassie starts with diabetes as it is an immense burden for 40 million people in Europe. Current glucose monitoring technologies are underused because they are highly invasive, expensive, stigmatising and generate a lot of waste.Lassie will transform this situation by making measurements painless, simple, discreet and cost-effective without any consumables. By analysing Volatile Organic Compounds (VOCs) in the breath, Lassie will calculate blood glucose value within current accuracy standard. As a result, Lassie users will test earlier in the disease and more frequently, leading to better diabetes management and significant cost savings. EIC Accelerator will put BOYDSense on track to become a global leader in non-invasive diabetes monitoring.


**Keywords:** Diabetes,non invasive monitoring,breath,VOCs,Volatile Organic Comppunds,biomarkers,glucose monitoring,sensor,chronic disease,digital health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Computational toolbox for protein surface docking' to be submitted under Sixth Framework.

assistant: **Abstract**

Recent combinatorial biotechnologies have shown that the molecular recognition capability of proteins can be specifically oriented toward inorganic surfaces. The use of technologies based on such specificity would give European industry a competitive edge in several emerging fields (from nanoelectronics over biomaterials science to drug design), spanning different thematic areas of FP6. However, at present the principles regulating protein-surface interactions are poorly understood, thus hindering such technologies from taking off. What features of the surface and of the proteins (electronic, structural, morphological) determine which protein is able to bind to a given surface and how? PROSURF will answer this question and provide the European scientific/technological community with computational tools to enable rational design of protein-surface associations. As automated in silico docking revolutionized the process of drug discovery, so the outcomes of PROSURF will open genuinely new routes to solve several urgent technological problems, such as self-assembly of nanoelectronic devices or design of highly biocompatible materials. PROSURF is risky because it addresses a largely unexplored subject; however, the risk is compensated by the potential of enormous impact. Our strategy to probe the determinants of protein-surface specificity, and to implement the envisaged computational tools, integrates state-of-the-art computational techniques and experiments. It consists of a series of computational steps, including quantum-mechanics based parameterisation of protein-surface interactions, molecular dynamics simulation of proteins on surfaces, and the implementation of protein-surface docking software, corroborated by tailored experiments. Although the project focus is on th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Chinese Network for primary immunodeficiency' (PIDNET).

assistant: **Innovation**

We have previously created a network for colleagues working on the genetics of primary immunodeficiency diseases (PID) and their treatment within the EU. This project is one of the finalists for the Descartes Prize in 2005. We extended this work to encompass the NAS countries in 2001, again within an EU-funded framework. This has led to a marked increase in quality of the care for this patient category in Europe.It has also led to a scientific advantage for Europe in understanding the background of these diseases and potential cures. China represents a vast untapped resource for patient samples and ideas for future therapy. Professor Hammarström, a professor at Karolinska Institutet, the coordinator of this application, works part-time as a guest professor in the medical school of Peking University (also referred to as Peking University Health Science Center). Karolinska Institutet recently opened an official liaison office on the campus of the medical school of Peking University.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combining Electrons and Phonons in Twisted materials' (ComEPT), addressing dissemination and exploitation.

assistant: **Impact**

The recent discovery of correlated insulating states and unconventional superconductivity in twisted bilayer graphene triggered an intense research effort to understand the properties of moiré materials. The ability to manipulate electronic properties through the twist angle between two two-dimensional materials has given rise to the new field of twistronics. Besides novel electronic properties, moiré materials also feature unconventional vibrational properties, such as novel phason modes. The ability to control vibrations by twisting gives rise to the new field of twistnonics.Despite much progress, many experimental observations in moiré materials are not yet well understood. For example, the microscopic origin of the “strange” metal phase with a resistivity which is linear in temperature and the nature of pairing glue that induces superconductivity are hotly debated. To answer these questions, I propose to combine the fields of twistronics and twistnonics and study the role of electron-phonon interactions in twisted bilayer materials. Specifically, I plan to+ develop a computational framework to study electron-phonon interactions in moiré materials. Because of the large unit cells of moiré materials, standard implementations of this approach cannot be used. To overcome this challenge, I will combine force-field approaches for phonons with tight-binding methods for electrons and develop a new parallelized computer code.+ understand electron transport experiments in different twisted bilayer materials, including twisted bilayer transition metal dichalcogenides and twisted bilayer graphene. + study the electron-phonon mediated superconductivity in twisted bilayer materials. The results of these calculations will enable a detailed understanding of the interactions between
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A validated simulation support system for the optimal design of steel shaped can manufacturing processes (SCANMAP)' (SCANMAP), addressing dissemination and exploitation.

assistant: **Impact**

The project aims to facilitate the development of a wide range of shaping possibilities for steel food, beverage and aerosol canisters. The requirement to innovate in terms of shape responds to increasing consumer demands for attractive and differentiated packaging in these sectors, and to the concurrent move towards brand reinforcement via packaging which is a key goal for retailers and fillers. Such developments will allow steel based containers to compete more effectively with alternative systems. The objectives of the project are to utilise and further develop the existing computational tools available to the partners in order to provide an industry standard simulation capability to aid decision making in the optimal design of shaped can forming operations. The main project output will take the form of a validated computational decision support system, which will permit modelling of the entire manufacturing process for shaped steel cans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Disruptive PEMFC stack with nOvel materials, Processes, arcHitecture and optimized Interfaces' (DOLPHIN) targeting Horizon 2020.

assistant: **Abstract**

Current PEMFC stack technologies for automotive applications show limitations in performance, durability and production cost which are primary challenges to reach mass production and fuel cell commercialization. It is obvious that filling the gap between present State Of the Art performances and expected targets will not be possible by an incremental evolution of the present PEMFC technology as deployed today in first commercial cars. Thus, it is necessary to identify, develop and validate a more innovative, disruptive approach including new materials and processes to have a chance to reach these ambitious challenges.In this perspective, the DOLPHIN project is exploring an unconventional, highly innovative route towards a newly designed cell architecture featuring a Dual-Core Single Repeat Unit (DC-SRU).Thanks to smart approaches in the fields of ‘Process Integration’, ‘Interfaces Quality’ and ‘Materials Efficiency’, DOLPHIN will deliver a light-weight & compact fuel cell and stack architecture with low (mass/charge) transport resistances inside the fuel cell core. Mechanically strong and corrosion resistant structures with redesigned and more coherent cell-internal interfaces will delay the activation of major ageing mechanisms and failures occurrence hence increasing system reliability to a level compatible with automotive durability targets. Finally, by triggering an original concept relying on two integrated multi-functional cores and two architectures (w/o GDM) of increasing level of disruptiveness, DOLPHIN will finally deliver a reinvented process scheme with projected stack production costs less than 20 €/kW. DOLPHIN will in that sense address drastic fuel cell stack requirements for the automotive industry and beyond. It consists in another step forward toward t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A Bayesian sense of probability in the human brain: Its characteristics, neural bases and functions'.

assistant: **Objectives**

Bayesian inference optimally estimates probabilities from limited and noisy data by taking into account levels of uncertainty. I noticed that human probability estimates are accompanied by rational confidence levels denoting their precision; I thus propose here that the human sense of probability is Bayesian. This Bayesian nature constrains the estimation, neural representation and use of probabilities, which I aim to characterize by combining psychology, computational models and neuro-imaging.I will characterize the Bayesian sense of probability computationally and psychologically. Human confidence as Bayesian precision will be my starting point, I will test other formalizations and look for the human algorithms that approximate Bayesian inference. I will test whether confidence depends on explicit reasoning (with implicit electrophysiological measures), develop ways of measuring its accuracy in a learning context, test whether it is trainable and domain-general.I will then look for the neural codes of Bayesian probabilities, leveraging encoding models for functional magnetic resonance imaging (fMRI) and goal-driven artificial neural networks to propose new codes. I will ask whether the confidence information is embedded in the neural representation of the probability estimate itself, or separable.Last, I will investigate a key function of confidence: the regulation of learning. I will test the implication of neuromodulators such as noradrenaline in this process, using both within and between-subject variability in the activity of key neuromodulatory nuclei (with advanced fMRI), the cortical release of noradrenaline during learning and its receptor density (with positron-emission tomography) and test for causality with pharmacological intervention.Characterizing the se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Concerted Safety & Efficiency Evaluation of Retroviral Transgenesis in Gene Therapy of Inherited Diseases' to be submitted under Sixth Framework.

assistant: **Abstract**

CONSERT will integrate leading European activities for a structured implementation of novel therapies using genetically enhanced postnatal stem cells, with focus on the treatment of monogenic immunodeficiencies, hemoglobinopathies, anemias and storage disorders. CONSERT will develop and evaluate methods for genetic stem cell modification with wide implications for many other disorders including viral infection and cancer. A central theme of the project is an unbiased safety and efficiency evaluation of the key technology used in the genetic modifications of replicating somatic cells: retroviral vector-mediated transgenesis. This is only possible through concerted multi-center studies. Lenti-, spuma- and gamma-retroviral vectors will be tailor-made for target disorders and tested for potency and safety in preclinical disease models. Designed with a translational aim, basic studies in stem cell biology and selectable marker technology will complement this research. A most important aspect of CONSERT is the molecular and clinical monitoring of currently active and successful clinical trials of genetic therapies. This will create a paradigmatic data-mining activity to obtain insights into crucial issues of clonal kinetics of gene-modified cells in vivo. Molecular studies in precise cell systems and animal models will provide the mechanistic understanding of transgene-host interactions. This project will generate the basis for technology development and promote patient safety. Translational dissemination of know-how from academia to industry will create a network of cell processing manufacturers with large economic potential, and prepare future clinical studies with improved predictability. Supervised by a proactive ethical project, CONSERT will stimulate a competitive and c