RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Social Network Implementation of Health Campaigns Among Youth' under Seventh Framework.

assistant: **Concept**

Western societies devote substantial resources to media health campaigns, especially targeting young people. Unfortunately, health campaigns often have disappointing impact. There is a compelling need for insight into campaign implementation in social life. Especially among youth, the social environment plays a crucial role in message processing. Therefore, health campaigns can only be improved with a multidisciplinary approach that can predict youth’s behaviour within their social environment.The proposed programme aims to develop a method for effective campaign implementation via youth’s social networks. This method will (1) identify and target the most powerful influence agents in youth’s social networks, (2) tailor campaign messages to the most effective influence mechanisms, and (3) evaluate the effectiveness of social network implemented campaigns. The method will be based on the multidisciplinary Media X Social Influence (MXSI) model, integrating theories from communication, marketing, psychology, and sociology.Five research projects focus on youth’s weight-related behaviours. Drawing on a large-scale cross-sequential cohort study (N = 3,000, 9-15 y/o), the research (Phase I) tests and refines the MXSI model, identifying social influence agents and mechanisms, and (Phase II) tests the effectiveness of a social network-implemented health campaign in a group-randomised control trial, targeting the most powerful influence agents and mechanisms. The research projects use the Wearable Lab, a highly innovative smartphone-based research methodology.The project is theoretically and methodologically pioneering and will produce a unique and useful method for improving health campaigns. Feasibility and success are guaranteed by the applicant’s extensive experience and netwo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Kraków geometry in mathematical physics' (KRAGEOMP).

assistant: **Innovation**

In recent years we have witnessed a remarkable renaissance in the interaction between geometry and physics. Our research concentrates on topics in mathematical physics, which have geometry at the heart: differential geometry of manifolds linked to gravity and string theory, metric aspects of Kähler manifolds, singularities and topological defects and non-commutative geometry.The proposed project is centred around extending mathematical competence of the host group, by providing transfer of knowledge in modern mathematics: geometry and partial differential equations, related to our research. By concentrating on recent developments in mathematics and mathematical physics we shall aim at reinforcing the inter-disciplinarity of our research, creating a fertile environment for successful research linking mathematics with interesting problems of theoretical physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The multispace project for quality in multimedia products' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The MultiSpace project is an initiative to promote improved quality for multimedia applications and systems within Europe. Of particular importance is the assistance to SME (Small and Medium Enterprises) producers to achieve the confidence of new clients. Objectives The MultiSpace project will develop an approach for describing the quality of multimedia applications and systems, including the components and objects within them. The Approach will consider technical issues, user-centered issues and contextual/social issues. Priorities for its adoption will be established. The entire Approach will be made public. The MultiSpace project will also provide methods and materials that support quality improvement. The project will deliver these as a preliminary version of the 'Multimedia Quality Box'. The methods will be suited for subsequent experimentation, improvement and exploitation. There will be data definitions that support the MultiSpace Approach, including prototype versions of methods of improved requirements specification and quality definition for multimedia applications/systems and their components. The Multimedia Quality Box will also make provision to include methods for the testing and evaluation of applications/systems against these requirements. In addition the consequence of these quality-orientated actions upon project management will be supported by drafted methods for configuration control, risk management and product sizing. There will be training materials targeted at different audiences. The MultiSpace project will also adapt intelligent tutoring technologies to conform with and demonstrate these quality concepts. A demonstration version of the 'Quality Tutor' will be produced to show that it is possible to teach the concept of quality in multimedia thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Study Of Seismic Hazard Due To Smaller Mediterranean Earthquakes'.

assistant: **Concept**

Earthquakes are natural hazards causing significant damage both in cost to human life as well as property. Most recently, adjacent to Europe, on June 27, 1998, an earthquake in the Adana basin of eastern turkey killed several tens and destroyed much man-made constructions. A fundamental step in seismic hazard assessment is refinement of our knowledge of smaller earthquakes those that are the source of major hazard in Europe and adjacent regions. Due to complexities introduced by propagation of waves through upper mantle, waveforms from small events recorded at intermediate distances are difficult to interpret. A powerful tool to overcome this problem is the Gaussian beam summation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative tag system providing affordable time-temperature quality control of individual temperature sensitive products' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The cold-chain is the temperature controlled supply chain used to transport temperature-sensitive goods such as dairy products, chocolate, fresh vegetable, vaccines, etc. Any breach in the cold-chain that exposes the goods outside these temperatures is referred to as a thermal excursion. In the EU alone, over 60% of the food losses occur due to failures in the logistical chain, making it a priority to improve the methods of tackling the inefficiencies in the cold-chain. To identify the points in the process at thermal excursions take place we can use Time Temperature Integrators (TTIs), which are attached to the product packaging and help track the temperature history throughout the cold-chain. Our solution at Scriba Nanotecnologies Srl is the T-TAG, a quality control TTI adhesive label that uses thermosensitive materials that undergo an irreversible change in their optical contrast when exposed to particular temperature ranges. We already have T-TAG prototypes tested and ready for industrial validation that can monitor thermal excursions above 8°C for periods of 48h. The optical contrast signal can also be monitored using a simple reader or most smartphone cameras, allowing to standardise the readout and automate the process to easily interpret and log thermal excursions. The innovation of the label design enables its small size (16mm x 20mm and 1mm thickness), which also means one can track individual packaging. We plan to set-up the mass production of the T-TAG to reduce the cost of manufacturing to €0.006 per tag, making accurate quality control possible at a fraction of the price of competing solutions – €0.15 per tag compared to €0.80-8.00 for thermochromic labels and data loggers. Our initial sale predictions based on a product launch by 2019, aim for an accumula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of chiral organometallic complexes as new catalyst for the enantioselective ring-opening of meso 1,2-epoxides and aziridines with carbon nucleophiles' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content: Development of new chiral catalysts for the ring-opening of three-membered heterocycles with carbon nucleophiles. I Training content (objective, benefit and expected impact):The Host Institution can provide an unique opportunity for Research Training in the field of enantioselective catalyst. Links with industry / industrial relevance (22): The successful development of this new methodology would be of considerable relevance for industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Unified DR interoperability framework enabling market participation of active energy consumers'.

assistant: **Concept**

Buildings constitute a vast, yet currently untapped, source of energy demand flexibility that can provide invaluable services to the energy system. This flexibility currently remains unattainable due to the lack of a technological framework that can connect the multitude of buildings and building systems with the energy system in a cost-effective manner as well as the reluctance of energy consumers to enroll in demand response programs.DRIMPAC offers a comprehensive solution to empower consumer to become active participants in the energy markets. It comprises three main pillars:a) A legacy and Standards-compliant interoperability framework to interconnect building energy loads/appliances and expose their demand flexibility as price-responsive demand to the grid or for market actors to aggregate and bid in ancillary service markets.b) A human-centric, intelligent building energy management system that will lift the burden of demand response from the consumers shoulders and reduce reluctance and fear of participation in DR programs. It will infer user comfort preferences and dynamically control building loads to minimize energy cost and use for the building occupant leveraging dynamic prices, while always preserving comfortable and healthy indoor conditions.c) Innovative business models and service offering for energy retailers in order to facilitate their transformation from commodity suppliers to digital energy service suppliers and kick-start the deployment of the DRIMPAC solution in the market.The DRIMPAC technological framework and business models will be validated by four retailers supplying three energy carriers – electricity, natural gas and district heating – in four different national markets across the EU - France, Cyprus, Germany and Spain. Pilot demonstration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dissemination and facilitation for European research in selected chains' (DIFFERENCE).

assistant: **Concept**

Main Objective  The main objective of DIFFERENCE is to facilitate the cohesion of selected elements of architecture emerging from the ACTS programme and Industry in support of a European Open Service Market.  Technical Approach  This project will ensure that ACTS projects' results are more appropriate to industry by establishing close links to industry fora and Special Interest Groups (SIGs). These will include OMG, EURESCOM, DAVIC, TINA-C and the Network Management Forum (NMF). Interaction with SMEs, who do not typically support these fora, will be achieved using the electronic dissemination services of SMARTS and INFOWIN.  Members of the project will bring current industry thinking on architecture to ACTS by participating in and contributing to relevant concertation (domain, cluster and chain) meetings). The telecoms business is increasingly using components from industry to achieve cost effective system solutions and the task of this project will be to assist and enhance this trend in architecturally related ACTS chains, in particular the NIM and SIA chains together with the CLIMATE cluster. These opportunities will also be used to provide feedback from industry and ensure that experts engaged by the project are vectored to the key project actors (see Figure 1).  This project will assist in providing an overall view of the relationships between a number of architectural frameworks and engineering disciplines that will have to be brought together for Trans-European IBC deployment. These common architectural frameworks include TMN and distributed system 3-tier frameworks, intelligent network frameworks, service management and creation frameworks, and Telco management services and computing system management.  Since the objective of DIFFERENCE is to leverage what is alr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DOMAIN-PHOS: Towards large-scale functional characterization of protein phosphorylation' to be submitted under Horizon Europe.

assistant: **Abstract**

In recent decades, phosphoproteomics has greatly advanced our ability to quantify protein phosphorylation. However, characterizing the functional consequences of these phosphorylation events remains challenging, with only ~6% of recorded events having an associated function. This project aims to bridge this gap by developing a high-throughput method for characterizing biochemical functions of phospho-events.The proposed approach, supported by preliminary data, leverages the fact that some protein domains recognize phosphorylation of other proteins, thereby defining the function of both the binder and the phospho-substrate. For example, 37 human proteins contain the phospho-binding Forkhead-Associated (FHA) domain, each with a slightly altered sequence influencing substrate choice. FHA proteins act in various processes, including DNA damage response and cytoskeletal movements, areas of expertise for the applicant.The project involves GFP-tagging all human FHA domains for use in affinity pulldowns, followed by mass spectrometry for comparative analysis of phospho-substrates. For validation, we will perform large-scale reciprocal phosphopeptide pulldowns, a technique developed in the host lab. The combination of the applicant's expertise and the host lab's methodology creates a strong synergy. To understand structure-function relations, we will model interactions of shortlisted FHA:phospho-substrate pairs using AlphaFold3. Additionally, we will conduct phenome-wide association studies to find links between mutations in interaction pairs and disease states, including the functional follow-up on disease-relevant findings.The appeal of this approach extends beyond expanding FHA domain biology, as it has the potential to generalize to other post-translational modification- (PT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High speed punching. New design of punching tools for high speed production and increased flexibility' (1994-1998).

assistant: **Innovation**

The proposed research will produce a punching tool capable of running at very high speed (up to 2400 versus 900 - 1000 strokes today). A new design drastically increases the flexibility of the punching process. A new modular design allows a rapid change of parts of the complete tool. The industrial objective of the research is to reduce lead times in the product development cycle in the industries mentioned, and to increase production speed in the production of sheet metal parts. Whilst the above objectives apply primarily to the users of punching tools, the objective for the designers and manufacturers of the tools is to enhance competitiveness among European toolmakers by introducing a new and highly efficient design. Working speed as high as 2400 strokes per minute is obtainable by redesigning the tools, using lighter material than steel in the tool base (titanium is considered) in combination with punches and dies made of cemented carbides. Ideas as to how to apply elements of adaptive control in the tool will be tested, resulting in minimised breakage risk and increased speed. The project is proposed by a Danish and a Swedish SME, working jointly with a large user of punching tools and two research institutes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Precarity Amongst Women Migrant Nightworkers in Ireland'.

assistant: **Concept**

PRECNIGHTS is an ambitious anthropological project on labour migration and precarity, contributing with novel theory on differential inclusion of the essential, yet invisible women migrant nightworkers (WMN) in Ireland. Through an innovative interdisciplinary and ethnographic approach, the research will impact scholarly debates in migration, and will inform key Irish and European stakeholders on migrant workers’ rights. To reach these aims, PRECNIGHTS’ objectives are: 1) Unpack how are WMN expected to perform their gender in nightwork; 2) Explore factors that affect WMN’s responses to invisibility and precarity; 3) Examine how management practices and work culture impact WMN’s understanding and crafting of their self-presentations; and 4) Unpack the structural invisibilisation and precarisation of WMN. PRECNIGHTS aims to make visible WMN through intersectional methodology that not only examines precarity, migration, gender and nightwork, but also focuses on how each of these four dimensions magnifies the lived experiences of the others; and, further, through ground-breaking, digital, and nocturnal ethnography that captures night experiences. Together, these enable an inclusive analysis of the lack of ‘power and privilege’ and the forms of ‘oppression and inequality’ faced by WMN. PRECNIGHTS, thus, uniquely contributes to scholarly efforts and policy work dedicated to understanding the contemporary European labour migration regime, which produces conditions of marginality in urban settings, not just in Ireland, but also in other EU contexts. PRECNIGHTS will be hosted by ISS21, University College Cork and will progress under Dr Caitriona Ni Laoire’s vital supervision, as her background and expertise in qualitative multi-modal research and socio-spatial dynamics of inclusi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Uncovering the regulation of transthiolating and RING E3 ligase activity by metabolites' under Horizon Europe.

assistant: **Concept**

The ubiquitin system, a central regulator of cellular processes, relies on the activity of approximately 650 E3 ligases to mediate the ubiquitination of cellular entities. This activity is tightly regulated to avoid aberrant ubiquitination, a hallmark of numerous diseases. While several regulatory layers of ligase activity have been documented, a novel factor – activity control by metabolites – remains vastly underexplored. A key bottleneck for uncovering metabolite-driven regulation has been the lack of appropriate tools for activity read-out of cellular ligases. However, in the past few years, innovative activity-based probes have been added to our toolbox. In this proposal, I will exploit complementary E2~Ub-mimicking probes to monitor the proteome-wide activity of both transthiolating and single subunit RING E3 ligases after manipulation of intracellular metabolite pools. By coupling mass-spectrometry-aided ligase-agnostic profiling with biophysical characterisation of the interaction, I will chart the metabolite E3 landscape, deepen our mechanistic understanding of ubiquitin regulation, and uncover new therapeutic entry points for diseases such as cancer and neurodegeneration.


**Keywords:** Post-translational modifications, ubiquitylation, activity-based probes, E3 ligases