RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Lipid antigens in intestinal inflammation and tumor development', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Lipids play crucial roles in metabolism, immunity and cancer. In addition to their function as inflammatory mediators, lipids serve as antigens presented by CD1d and activate a subset of T cells called natural killer T (NKT) cells. While NKT cells are critical for human immunity, their uncontrolled activation contributes to inflammatory bowel disease (IBD), a group of diseases characterized by chronic intestinal inflammation and an increased risk of colorectal cancer (CRC). Specifically, NKT cells are the major source of pathogenic TH2 cytokines in the inflammatory bowel disease ulcerative colitis (UC), are sufficient to cause intestinal inflammation in mice, and are required for colitis and colitis-associated cancer in a mouse model of UC. These observations suggest that targeting of lipid antigen presentation may be of therapeutic value in IBD, where current therapies are of limited efficacy and aim at control rather than cure of disease.Here, I propose to identify the lipid antigens responsible for NKT cell-mediated intestinal inflammation and colitis-associated cancer in human IBD and mouse models of intestinal inflammation and to develop therapeutic strategies for interference with pathogenic lipid antigen presentation. Specifically, I propose to characterize the intestinal inflammation- and cancer-associated CD1d lipidome based on novel in vitro and in vivo models of cleavable CD1d and a recently established lipidomics approach. Furthermore, I propose to develop strategies for inhibition of the generation, loading and presentation of inflammation- and cancer-associated lipid antigens. These studies combine biochemical, immunological and high-throughput technologies in an interdisciplinary manner to provide the knowledge required for the generation of novel, effica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Psychology of Legal Instrument Choices: An Experimental Approach to the Expressive Function of Labour Law' in the context of a Sixth Framework call.

assistant: **Objectives**

The proposed research is aimed at empirically evaluating specific legal instruments based on their psychological efficacy in various legal settings. The project highlights the importance of taking psychological perspectives into account when selecting an optimal instrument. The optimal legal instrument will be evaluated based on its ability to cause people to engage in cooperative behaviour, to be perceived as more legitimate in regulating specific behaviours and according to its ability to mobilize social norms in a desired direction. The psychological and sociological theories that I will draw upon will be theories of legitimacy, justice research, social norms, attitude change and cooperation in groups.The project will focus on employment settings as a case study for the comparison of contracts, laws and collective agreements. Following the general argument described above, the project will attempt to explore what legal instrument is best for which sector (e.g. high-tech; blue collar) and for what kinds of norms (e.g. privacy, ownership, employee benefits). This project will use field survey combined with experimental methodology. I will use various samples of employees from different sectors of the industry. Within each sample, I will use a priming technique, operationalized by random assignments of stylised vignettes to subgroups of the sample, in which the content of the norm will be identical, only the source of the norm will be manipulated.This procedure will be conducted on various legal norms and sectors and will allow me to compare the affect of the legal source on factors such as legitimacy, willingness to comply, and perceived social norm. This experimental approach will allow me to evaluate not only what source is optimal but also whether one could find an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Field usable gearing fault detection and analysis system' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The scientific and technical objectives of this research proposal are: to develop a technology capable of diagnosing geaving defects and predicting accurately time to failure. Research and development is required into measurement technique, both hardware and software, and in diagnostic tools. Once technologically proven the system needs to reduce in size to be easily carried and made intrinsically safe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Anti-democratic/anti-gender nexus in Bosnia and Herzegovina' under Horizon Europe.

assistant: **Concept**

The recent rise in anti-democratic discourses and politics in Europe has been linked with a rise in opposition to women’s and LGBTIQ* rights. I call this link the “anti-democratic/anti-gender nexus” and argue that we need to explain the exact nature of the link, to understand the rise of, and develop strategies to combat, de-democratization processes in Europe. The project AntiGenderInBiH focuses on how gender and sexuality are governed and framed in Bosnia and Herzegovina (BiH). As a potential EU accession candidate, BiH has positively identified the need to promote diversity and equality within its population. Yet opposition to them, and particularly to LGBTIQ* rights, has been increasing. Working with Prof. Roman Kuhar at the University of Ljubljana, I will pursue two connected research objectives. Firstly: to analyse the “anti-democratic/anti-gender nexus” empirically in the BiH context. By applying a triangulation of methods, including Interpretative Policy Analysis and Critical Frame Analysis, I will analyse policies developed on the national and the level of the two entities Federation of BiH and Republic of Srpska relating to the governance of gender and sexuality issues as well as discourses on these issues mobilized by media and activists. Through this, I will identify potential anti-democratic/anti-gender frames, policies and networks, in BiH. Secondly: to conceptualize the “anti-democratic/anti-gender nexus” theoretically, combining my data with a critique of existing theoretical explanations. This will provide novel theoretical explanations that will allow myself and other scientists in the field to identify the links between anti-gender and anti-democratic discourses and politics and explain the rise of the “anti-democratic/anti-gender nexus”. The novel em
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Light-controlled synthetic enzyme cascades'.

assistant: **Objectives**

There is an urgent need for the development of greener syntheses procedures if mankind wants to maintain an environment worth living in but is at the same time unwilling to accept a reduction in material comfort. The establishment of more biocatalytic steps in chemical syntheses is one possible solution, as enzymes and whole cells offer sustainable advantages, such as biodegradability, intoxicity, high selectivity, and many more. As a myriad of enzymatic reactions exist for almost any product, their potential is immense. Great scientific achievements and new techniques recently developed have enabled the design of economically and ecologically feasible multi-step enzyme cascades. However, with these new opportunities, also new challenges arise. The more enzyme steps are combined in one pot, the higher the risk of undesired cross-reactivity is. There is thus an urgent need for a tight control of each biocatalytic step in a cascade in order to obtain the desired product in a high purity and to make use of all advantages that enzyme cascades intrinsically offer. With LightCas, I aim to break new grounds in the area of multi-step (bio)catalysis by enabling an orthogonal, selective and thus flexible on/off tuning of enzymes in a cascade. By entrapping enzymes into light-switchable microgels, using photo-switchable active site lids and light-induced enzyme deactivation, three methods providing the opportunity to control enzyme activity in vitro and in vivo on demand will be (further) developed. The ultimate goal is to set up a one-pot multi-step light-controlled enzyme reactor yielding the desired product in high selectivity and concentration in a technically self-regulated manner.Beyond the ground-breaking direct impact in the field of enzyme catalysis, huge gains in knowled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rediscovering the Wanderer: restoration of sympathico-vagal disbalance in irritable bowel syndrome by neuromodulation – a novel therapeutic concept' (RESILIENCE) targeting Horizon Europe.

assistant: **Abstract**

Common colloquial phrases like ‘gut feeling’ or ‘butterflies in my belly’ are not just idioms but reflect on the unique communication between gut and brain. The principal interface for this interaction is the autonomic nervous system — a largely subconscious system that manages bodily functions through a delicate balance between its two branches: the sympathetic and parasympathetic nervous systems. The vagus nerve is the main component of the latter. Diminished vagal tone resulting in increased sensitivity to pain is characteristic for many chronic pain disorders, including irritable bowel syndrome (IBS). People with IBS have frequent and often severe abdominal pain. While its etiology remains poorly understood, IBS is now assumed to be caused by a malfunctioning of the gut–brain axis, often manifesting in sympathetico–vagal disbalance. However, no established therapies currently target this neurological disturbance.   I hypothesize that restoring the sympathico–vagal disbalance through autonomic neuromodulation can be an important novel therapeutic target in IBS. To achieve this, I will use transcutaneous electrical vagus nerve stimulation via the auricular nerve. I will also develop a novel multimodal ‘vagal-autonomic neurosignature’ through combining actively and passively recorded biometrics and high-power field neuroimaging. This profile will allow identification of patients who could benefit from the new treatment approach. Simultaneously, I will investigate mechanisms of action in a comprehensive manner, using experimental models and tools I have previously developed.  My project is foreseen to fundamentally change the therapeutic landscape of IBS and other pain disorders by providing high-quality clinical and mechanistic evidence for the efficacy of vagal neurom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'MoveWise-Research project'.

assistant: **Objectives**

This proposal for the project MoveWise-Research (MW-R) is submitted for the call INNOSUP-02-2016 “SME Innovation Associate”. AETHON requests to hire a post-doctoral researcher with sufficient academic experience on transportation engineering, data analytics, behavioural analysis and IT programming for the purpose of performing a proof-of-concept research (TRL 5 – development of model/algorithm) on modelling tours incorporating user feedback. The key objective of the MW-R project is to develop a model/algorithm for planning of tours and trips in real time incorporating user preferences and data on traffic obtained from public (and open) sources. The model will be created by using data from public transport authorities in Greece and by performing a small scale survey to obtain user feedback on trips. By achieving the MW-R goal, the model will be able to change the perspective of travellers by providing targeted information about planned routes that will improve mode, route, time of departure and destination choice. AETHON aims to incorporate the model in a smartphone application and to gain knowledge on transportation behavioural analysis that can be used in multiple professional activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EUROPEAN WATER INITIATIVE - ERA-NET; Coordination of Member State research programmes in water science and technology for the developing world' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The EUWI-ERA-NET is a consortium of 15 ministries, funding agencies and national RTD authorities from 11 European countries. The ERA-NET will establish a framework for long-term communication, collaboration and coordination of member state research programmes on water issues in developing countries, helping to establish EU leadership in harmonisation and alignment of donor actions with developing country partners. This ERA-NET underpins the delivery of commitments made at the Johannesburg WSSD, in particular the research coordination outlined in the EU Water Initiative. Water strongly affects many development issues (health, industrial growth, agriculture, disasters, energy, gender, etc) so the EUWI-ERA-NET is expected to encourage ERA-NET actions on other development issues. An SSA instrument has so far built consensus and a shared vision of what may practically be achieved, respecting national interests and resources.EUWI-ERA-NET will:-Establish a Consortium framework using adaptive management, providing for the integration of new partners during the life of the CA-Engage the main developing country partners and the research community-Collate and share knowledge from European water research for developing countries-Improve research and impact management practices-Transform knowledge into appropriate practice through consultation, building capacity and informing policy-Develop joint activities and programmes between national RTD programmes and other partners-Contribute to real improvements in the living conditions for the worlds poorThe EUWI-ERA-NET will work with other ERA-NET's in related fields as one of the building blocks in the process of preparing the Art 185 action focusing on infrastructure research (water, energy, transport) in international development. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart and Efficient Location, idEntification, and Cooperation Techniques' under Seventh Framework.

assistant: **Concept**

The project focus on studying innovative solutions enabling high-accuracy detection, identification, and location of objects/persons equipped with small ultra-low power tags using a network of intelligent self-configuring radio devices. Network functionalities will be enhanced to include the detection and tracking of moving objects/persons without tags eventually present in the same area.To achieve this goal, several technologies such as radio frequency identification (RFID), ultra wideband backscattering modulation, time reversal, relaying and energy scavenging, and associated advanced algorithms, will be considered and partly or totally integrated in a demonstrator. This will require the design of multi-frequency/multi-technology tags for system-neutral identification along the use lifetime of a tag, based on advanced concepts in low-consumption chip and antenna design.Innovative techniques will be considered to improve the location accuracy, increase tag energy efficiency and extend system coverage by a mixture of progress in the system architecture, in the detection and tag activation techniques, and in the complexity-performance trade off of chip design.Special emphasis will be given to the analysis and design of green" solutions by considering low complexity and low power tags through the exploitation of passive communication (without integrated tag batteries) as well smart cooperation strategies.Finally, single system components and the overall system performance will be validated through experimental characterization, hardware implementation, as well as simulation.Identification/detection reliability, tracking accuracy, power consumption will be amongst the major evaluation criteria.A wireless network integrating detection, identification, and location would lea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enhancing Engulfment of Apoptotic cells: basic biology to Therapy' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Our bodies turn over billions of cells every day to keep us healthy. Old, damaged or excess cells need to be cleared, and professional and non-professional phagocytes engulf cells dying by apoptosis. The efficiency of this process is critical for homeostasis, minimising inflammation, and promoting organ function. Deficiencies in engulfment predispose to autoimmune and inflammatory diseases, and the host lab has shown that mice deficient in molecular components of engulfment exhibit exaggerated inflammatory responses.We hypothesise that apoptotic cell phagocytosis can be boosted via small molecules that target the engulfment machinery, and that this could open new avenues for therapy in specific disease contexts.  Here, I propose to perform an unbiased drug screen to identify small molecule candidates that can enhance apoptotic cell uptake – that is, a ‘gain of function’ screen for engulfment. The host lab has recently developed a fluorescence-based engulfment assay to quantitatively measure apoptotic cell uptake. I will develop this assay into a high-throughput screen to test a large library of compounds. I will address the consequences of pharmacologically enhanced engulfment on professional and non-professional phagocytes, and employ state-of-the-art nucleomics and proteomics approaches to explore the cellular targets of these candidate molecules. Finally, I will test whether the administration of small molecule ‘engulfment enhancers’ can be of benefit in inflammatory disease models relevant to human pathology. This proposal uniquely exploits the complementary expertise of the host lab (pathways of apoptotic cell clearance) and myself (inflammation and disease models), while benefitting from the significant resources of the host institute. While the mechanistic comple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cultivating Leaders for Innovative Coatings and Additive Manufacturing Applications' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Too often, great research ideas as well as talented researchers from Europe are acquired by non-European players who turn them into impactful innovations whose economic benefits are realized outside the EU. In addition, the innovation divide between the widening countries and the other member states persists (patent applications per million inhabitants not reaching 15% of the EU benchmark). The problem of the inability to transform the potential of basic research into the development of commercially viable innovations thus becomes a serious obstacle for the sustainable economic development of countries such as the Czechia, Poland, and Slovakia.In response, the CLiCAM project will cultivate participating ERA talents into leaders who will make innovation happen through intersectoral collaboration. The innovation leadership provided by ERA talents shall transform participating research organisations from widening countries into innovation beacons turning basic research into sustainable prosperity in fields of coatings and additive manufacturing. In doing so, the project will create an R&I ecosystem contributing to the development of relevant key enabling technologies across three domains critical for Europe’s technological sovereignty: advanced manufacturing, advanced materials, and life-science technologies. The actions of the consortium will concern three pillars of innovation:(i) people – cross-sector secondments and Innovation Leadership training,ii) processes – reintegration actions and benchmarking initiative,iii) infrastructure – two virtual test bed ecosystems for better use of existing research facilities.The long-term impact will be to strengthen human capital base in R&I (qualified personnel for impactful innovation), initiate technology transfer activities (pat