RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Solution for body kinematics monitoring' under Horizon Europe.

assistant: **Concept**

Overall goal is to use GNSS as an support for IMU  to track whole body movements in the wild, for healthcare and wellness applications.The GESTUS proposal aims to address a clear need of movement workers, physicians, physical therapists, and athletic trainers. The need is to have a tool that allows for highly accurate tracking of the kinematics of the human body, for the entire duration of the activity.GESTUS proposes a solution based on the integration of GNSS and IMU within ad-hoc wearable devices, which allow for high accuracy for a long duration of time in the real environment. The solution then consists of an ad-hoc created data processing algorithm and a cloud platform, with associated communication infrastructure, to automate sensor management, data downloading, processing itself, and results fruition, analysis and sharing. The project and the solution it proposes is primarily aimed at remote monitoring of patients with, or potentially affected by, degenerative and neurological diseases such as multiple sclerosis or Parkinson's. In such patients, it is very important to monitor with great accuracy the movements of every part of the body, both for possible early diagnosis and to monitor the evolution of the disease, to evaluate the effect of ongoing treatments, and to plan in advance actions to mitigate symptoms.


**Keywords:** IMU GNSS wearableremote assistance healthcare
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Peer Learning for Innovation Management in SMEs' under Horizon 2020.

assistant: **Concept**

The objective of this project is to learn from sharing experience and exchanging different viewpoints and problems encountered while implementing support services and programmes aimed at fostering innovation management capacity in SMEs. The four partners will share the current support services offered to SMEs and will exchange good practices in order to renovate insights and develop a common Design Options Paper. The Design Option Paper will be the result of the peer-review process and will serve as a guide for other innovation agencies interested in implementing the addressed innovation support service. For the best use of the results of the project the goal is set on the possibility to reach as many innovation agencies as possible with the support of the European Association of Regional Development Agencies, EURADA.


**Keywords:** Peer learning, managing innovation, support services, SME innovation capacities, Design Options Paper, guide, implement innovation suppport service
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrical current measurement based on elastic waves propagation in dielectric materials' in the context of a Fifth Framework call.

assistant: **Objectives**

The instrument transformers, devices for the measurement electrical magnitudes, are key elements within the generation and distribution of electrical energy. Their importance has grown even higher due to the worldwide deregulation processes that face the electrical sector. However they are still manufactured with almost the same technological principles and methods of four decades ago. Thus, they are among the most expensive components of the control systems. Our main objective is the development of a new kind of measurement current transformer. The proposed system will operate with mechanical waves instead of magnetic flux variations. It will be based on magnetostrictive and piezoelectric materials, rather than copper coils and magnetic core. Preliminary estimates suggest that this approach could reduce 26% the volume, 72% the weight, 100% the isolating oil and 37% the manufacturing costs compared with an equivalent modern current transformer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'THE TORTOISE PROJECT'.

assistant: **Innovation**

The objective of the TORTOISE project is to investigate the requirements for subsea equipment protection, and to develop an innovative, low-cost energy absorbing system in line with these requirements. The design of such a system must also allow for ease of installation (including retrofit) and convenience of maintenance and workover of the protected equipment.There is a need for subsea protection. A number of new concepts for protection systems have been evolued. Preference at present is on systems to absorb initial impact and then deflect. A theoretical analysis of objects free-falling through water has been developed and refined. Results compare well with other models but correlation with experiment is awaited. Initial analysis of underwater impact has proved difficult.The initial phase of the TORTOISE project is directed towards obtaining sufficient information to determine logical design parameters for the protection system. This data-gathering phase will evaluate the risks and sources of damage, the types of installation to be protected, the behaviour of dropped objects underwater (experimental and theoretical analyses), impact mechanics underwater, etc., to provide a full understanding of design requirements. This work, combined with an initial evaluation of potential materials and structures and various conceptual design proposals, will enable targets and preferred routes for the subsequent phases of the project. Phase 2 will be directed towards the development of the preferred concept(s) and materials testing as required, as phase 3 is envisaged as the detailed, design construction and testing of the prototype protection system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Physics of Impact Cratering Collapse' (IMPACT) targeting Horizon 2020.

assistant: **Abstract**

This research project will study the formation of large meteorite impact craters, characterized by central peaks or rings, flat floors and terraced walls. The complex morphology results from the gravity driven collapse of a much deeper and narrower transient cavity. Standard material models fail to explain such a collapse and specific temporary weakening mechanisms have been proposed. The most successful approach, the Acoustic Fluidization (AF) model, relies on the temporary softening of heavily fractured target rocks by means of an acoustic field in the wake of an expanding shock wave originated upon impact.The project aims to (i) constrain the mechanics of large crater collapse, (ii) constrain AF parameters and enhance AF implementation into simulation software (iSALE), (iii) test the revised AF model with planetary case studies. These objectives will be achieved through a multidisciplinary approach: (1) Small-scale impact experiments will use a target of granular material, which will be acoustically fluidized by an external source to mimic the fluid-like rheology of planetary targets during collapse; (2) Numerical models of complex crater formation, which require the AF parameters to be constrained, will be calibrated and validated against experiments and up-scaled to dimensions of natural craters. The originality lies in combining the systematic laboratory experiments with numerical simulations to improve a widely used AF model.The fulfilment of the project will be ensured by the host and partner institutes, and the planned training activities (laboratory and modelling techniques). The results will be disseminated to the scientific community through peer-reviewed papers and conference contributions. The project will foster excellence in Europe by establishing a netw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Inspection Capabilities for Enhanced Ship Safety' (INCASS).

assistant: **Innovation**

In the day-to-day ship operations, structural and machinery failures may lead to major accidents, endangering crew and passengers lives onboard, posing a threat to the environment, damaging the ship itself and having a great impact in terms of business losses. Moreover, with the introduction and building of a big number of new ships, their monitoring and inspection from both regulatory bodies and Classification Societies has become more and more difficult in order to obtain the optimum inspection results and eliminating the hazards posed by high-risk and sub-standard ships. In this respect, the INCASS (Inspection Capabilities for Enhanced Ship Safety) project brings together a range of experienced and dedicated partners in order to tackle the issue of ship inspection, identification of high-risk ships, providing access to information related to ship surveys independent of the ship’s flag and inspection regime and moreover incorporate enhanced and harmonised cooperation of maritime stakeholders in order to avoid ship accidents, promote maritime safety and protect the environment. The INCASS consortium aims to bring an innovative solution to the ship inspection regime through the introduction of enhanced inspection of ship structures based on robotic platforms, providing ship structures and machinery monitoring with real time information using ‘intelligent’ sensors and incorporate Structural and Machinery Risk Analysis. Moreover, by introducing Condition Based inspection tools and methodologies, reliability and criticality based maintenance, providing an enhanced Central Database including ship structures and machinery available to maritime authorities (e.g. EMSA, Port State Control), Classification Societies and ship operators and eventually by developing a Decision Supp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New Directions for Structure Segmentation, Phenotyping, and Language Interfacing in Histopathology' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Progress in deep learning brings new tools and methods that start reshaping pathology practice and advancing research in oncology. As a postdoctoral researcher in the Mahmood Lab (Harvard Medical School, 2022–), I played a pivotal role in the development and evaluation of “foundation models” for pathology – general-purpose models that can be used for various downstream tasks. Despite advances, foundation models still face several key limitations that restrict their widespread adoption. First, these models are designed to provide “non-human interpretable” data representation, providing little actionable insights to practitioners. Moreover, they lack robust language interfacing capabilities, especially in providing quantitative information. Finally, they are predominantly focused on hematoxylin & eosin (H&E) staining, leaving other histopathology modalities largely untouched. In this context, I hypothesize that foundation models for pathology will remain limited in impact unless they incorporate key additional features: (a) off-the-shelf structure segmentation and phenotyping for downstream analysis, (b) interactive language interfacing capable of answering quantitative queries, and (c) expanded support for other modalities, e.g., immunohistochemistry. To bring these ideas to life, I introduce DeepSPIM. In DeepSPIM, I will semi-automate data labeling to train segmentation models that will be combined with large language modeling to build a language interface. I will evaluate the translational capabilities of the models in assisting pathologists with routine clinical tasks, and, exploring interpretable morphological correlates of treatment response in oncology. The goals of DeepSPIM are closely aligned with the technical skills I developed throughout my PhD and postdoc. Le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural and kinetic studies of XPF/ERCC1-DNA complex for drug discovery' (XPF-ERCC1).

assistant: **Concept**

Cancer chemotherapeutic drugs, such as platinum agents, work by producing DNA damage that causes cell-cycle arrest and cell death. However, DNA repair pathways can enable tumour cells to survive DNA damage induced by chemotherapeutic treatments. Platinum resistance is a major clinical problem in cancer treatment and there is a considerable interest in inhibitors of DNA repair pathways, that can increase efficiency of chemotherapy, when administered together. An attractive target to circumvent platinum resistance is XPF/ERCC1 heterodimer. XPF/ERCC1 is a structure-specific endonuclease that cleaves double- to single-stranded DNA junctions, and its function is directly linked to repair of DNA cross-links induced by platinum agents. Here, we propose a multi-disciplinary methodology that combines structural studies by Nuclear Magnetic Resonance Spectroscopy with kinetic studies by Kinetic Capillary Electrophoresis to elucidate the mechanisms of XPF/ERCC1 function and modulate its activity for potential therapeutic benefit. Structural and molecular insights of DNA binding will be coupled with kinetic rates of DNA cleavage and enzyme/substrate interactions. The combined information will be used to develop XPF/ERCC1 inhibitors by in silico screening. Currently structure-kinetics relationship is not well explored in drug discovery, although the residence lifetime of a drug determines the duration of a pharmacological effect. The ability to combine structural and kinetic parameters in validating computational hits should identify compounds with desired pharmacological properties at early stages and facilitate faster optimization phase. The research proposed here is highly beneficial to public health, because it would allow to develop combination therapies for cancer treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Turbulence chamber gasification with combustion-optimized gas engine and turbulence chamber treatment (development of components)'.

assistant: **Objectives**

Summary Known carburation procedures like - solid layer (e.g. shaftcarburation by Imbert, Jul-oven, thermo process by Wamsler) - solid bed (Winkler) (Kobra) - free jet (Koppers-Totzek) (Prenflo) - special procedures (Eisenbad, etc.) use air, oxygen or water steam as carburation medium. Problems arise during carburation like - varying heating value of the produced gas - humidity, degree of carburation, residual coke - tar content and the later engine coupling (new project) causes difficulties regarding return effects of the engine on carburation. The problems are decreased or almost totally removed by a suffieciently high carburation temperature ( 800-1000 C), long retention time and continuously operated carburation. By fluidizing chamber carburation which can be classified between fluidizing chamber and free jet carburation, these requirements can be fulfilled. The fluidizing chamber carburation is deducted from fluidizing chamber combustion, which company Prufling has realized from 1985 up to now in three projects with the help of public support by the Federal Ministry for Research and Development, EU-Themmie, German Association for Environment. Thus all experiences which company Prufling made during the development of the combustion unit, are used in order to develop this carburation technology until the operation of a 200 kW pilot plant in the frame of this project. The gas engine of company Jenbacher is optimated regarding combustion, whereby company AVL-Graz optimizes the four-valve head regarding combustion technique and TU Graz optimizes the suction and exhaust section regarding flow technics. The main target is a considerably improved CO slip. A fluidizing chamber treatment serves for secondary combustion of combustible solid (coke) and gas (CO) components in o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular and functional analysis of presomitic mesoderm patterning and segmentation during murine embryogenesis' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Somites constitute the most obvious segmental pattern in vertebrate embryos. Each segment represents a clonal compartm and altogether they form the axial skeleton, the dermis of the back and all striated muscles of adult animals. Somites are therefore essential for establishment and proper development of the basic body plan. During embryogenesis, bi-lateral pairs of somite appear in a rostro-caudal order by progressive segmentation of the anterior presomitic paraxial mesoderm. However, little is known about the genes and molecular mechanisms controlling segmentation in vertebratesDr. Herrmann is conducting a large scale expression screen using whole-mount in situ hybridisation on mouse embryos to identify genes specifically expressed during somitogenesis. I screened 800 cDNAs and found novel genes specifically expressed in the developing somites. In particular, the expression patterns of 2 novel genes strongly suggests their involvment in the presomitic mesoderm segmentation process.I will determine the role played by these two genes during somitogenesis by creating loss-of-function alleles by homologous recombination into mouse ES cells. The characterization of these two genes will also include a more complete molecular analysis, the generation of antibodies and extended expression analysis during development of normal and Brachyury and deltalike 1 mutant embryos. In parallele, I will also continue the expression screen on 1000 additional cDNAs clones. Training content (objective, benefit and expected impact) The originality of this approach is in the possibility to screen large number of cDNAs and in the fact that the newly identified genes are readily available to be used as molecular markers or to initiate functional studies. I will g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biochemical characterization of RNA silencing mechanisms and their alteration by viral proteins in plant cell-free systems' in the context of a Seventh Framework call.

assistant: **Objectives**

Posttranscriptional gene silencing (PTGS) is a form of small (s)RNA-mediated gene regulation with important roles in development, stress responses, and antiviral defense in plants. PTGS effectors, called RNA-induced silencing complexes (RISCs), have ARGONAUTE (AGO) proteins bound to single-stranded (ss) guide sRNAs as core components. RISCs recognize target RNA displaying complementarity to guide sRNAs, and inactivate them by endonucleolytic cleavage (or ‘slicing’) or by slicer-independent translational repression. A precise dissection of the underlying mechanisms has been, however, hampered by a lack of plant cell-free systems allowing reconstruction of key PTGS steps in vitro. Recently, a cell-free AGO1-RISC assembly system was developed in Japan, using extracts from evacuolated tobacco BY-2 protoplasts (BYL) and allowed to establish that AGO1-RISC assembly relies on molecular chaperoning by HSP90 and co-factor CYP40. The proposed project will further deepen the understanding of plant RISC assembly mechanisms and decipher the molecular underpinnings of other PTGS steps including Dicer processing and RISC-mediated translational repression. In parallel, the BYL system will be used to investigate, in a strict comparative manner, the direct targets and modes of action of several plant viral suppressors of RNA silencing (VSRs). These proteins have been studied so far mostly in transgenic plants, where feedback PTGS regulations, intrinsically variable VSR expression levels and indirect effects have led to an inaccurate- and sometimes contradictory- view of their action. BYL will bypass these caveats and improve our knowledge of VSRs on antiviral silencing, but also of PTGS, as VSRs will be used to stabilize transient, and thus far inaccessible forms of protein-protein and p