RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification and functional and mechanistic characterization of Wnt-regulated long intergenic non-coding RNAs', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation and proliferation in the adult, self-renewing intestinal epithelium. Wnt signaling activates gene expression through the induced formation of complexes between DNA-binding TCF factors and the transcriptional co-activator β-catenin. Constitutive, aberrant transcriptional activity of the TCF4/β-catenin complex, caused by mutations in APC, AXIN or β-catenin, is the primary transforming factor in colorectal cancer. At present, despite great inroads into the processes involved in Wnt-dependent transcriptional regulation, the mechanisms by which TCF4/β-catenin regulate target genes remain incompletely understood. My post-doctoral research on these mechanisms uncovered tantalizing clues for the existence of previously unappreciated layers in the Wnt-dependent repertoire of transcriptional targets and mediators. These clues point to the existence of long intergenic non-coding RNAs (lincRNAs), the expression of which is regulated by the Wnt pathway and which, in turn, mediate its transcriptional activity and output. The proposed work aims at i) the systematic identification of such Wnt-regulated lincRNAs ii) the discovery of the protein factors with which they interact and iii) the elucidation of their functional and mechanistic contribution to Wnt-dependent transcription. These studies promise to shed light on new players and principles involved in normal and abnormal intestine physiology and to generate novel therapeutic targets in colorectal cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Microscopic investigations of CO2 capture and scattering on liquid gas interface' (CAPZEO) targeting Seventh Framework.

assistant: **Abstract**

The ‘CapZeo’ IRSES exchange programme gathers four partners, three from Europe (Université Paris-Est Marne-la-Vallée, France – UPEMLV, Instituto de Estructura de la Materia, Spain – CSIC, and University of Hull, United Kingdom) and one partner from Morocco (Université Mohamed V-Agdal Rabat, Morocco – UM5A).Three from Europe (UPEMLV, CSIC and UULM) and one from Morocco (UM5A).This project includes an international symposium, a summer school and two scientific work packages. The first scientific work package focuses on the electronic structure calculations necessary to model the adsorption of CO2 on the Zeolitic Imidazolate Frameworks (ZIFs) at the atomic level. The parameters for the interaction between ZIFs-CO2 and CO2-CO2 pairs will be deduced and optimised, in order to maximise the capture of CO2. These microscopic parameters will be incorporated later into the macroscopic description to investigate the dependence on pressure and temperature of the adsorption process. The second scientific work package deals with the theoretical study of CO2 scattering on a liquid-gas interface at the microscopic level. The liquid side of the interface is modelled by a monolayer of ZIFs subunits adsorbed on a gold surface. The stereodynamics of CO2 scattering on these model surfaces will be treated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Widening EU-CELAC policy and research cooperation in Personalised Medicine' to be submitted under Horizon 2020.

assistant: **Abstract**

In order to strengthen the global efforts on Personalized Medicine (PerMed) and the cooperation of the EU-CELAC countries to them, a unique Bi-regional consortium of governmental and funding organisations is shaped with the support of leading stakeholders as associated partners. This project has the ambition to engage CELAC countries in the International Consortium on Personalized Medicine (ICPerMed) and in the ERANet ERAPerMed with the aim at advancing in the implementation of the Action Plan of ICPerMed based in the Strategic Research and Innovation Agenda, drafted by PerMed2020.Research on PerMed is a top priority for the EU as a strategy aimed at delivering personalised health and care solutions to benefit citizens. Results of R&I actions will generate and translate knowledge on disease aetiology and technological innovation into personalised health and care solutions. Areas of application include chronic, rare and communicable diseases. Research under this priority will also attempt to develop an outstanding economic impact due to the potential of PerMed to transform health systems.The collaboration of diverse actors from different world regions, disciplines and health-care systems are needed to implement in a holistic way new feasible and cost-effective PerMed approaches. Involvement in ICPerMed of RFOs and policy-making bodies from EU and from other regions, is the best way to push forward the impact of new findings and knowledge in the area.This CSA will be the vehicle for: i) Mapping existing programmes, capacities and expertise and gaps in CELAC countries; ii) Facilitating the incorporation of CELAC countries  in ICPerMed and in the ERAPerMed; iii) Fostering the participation of CELAC countries in research mobility and transnational projects on PerMed, and a p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Pinning of flux lines in high tc superconductors' (1994-1998).

assistant: **Innovation**

Superconductors imbeded in a magnetic field can only transport a dissipation free electric current as long as the induced flux line system remain static. Since high temperature superconductors are operated at elevated temperature thermal fluctuations are of paramount importance. The current project will make use of computer simulations in order to obtain a better understanding of the connection between the observed magnetization and creep rates and the properties of the flux system at given field, temperature, anisotropy, and pinning disorder. Hitherto the flux system has often been characterized in terms of its equilibrium phases. The magnetization and creep are, however, inherently non-equlibrium properties. It is accordingly important to develope a description which directly incorporate the out-of-equlibrium aspects of the measurements. The results of the computer simulations and connected phenomenological modeling will be juxtaposed the equivalent experimental data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'From biophysical chemistry to cell biology: Deciphering the role of lipids in the toxicity and spreading of protein aggregation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The LIPAGG project seeks to unravel the structural complexities of amyloid protein-lipid aggregates and investigate their role in pathological aggregation, cellular toxicity, and intercellular spread. Focusing on key human amyloid proteins—amylin (IAPP), amyloid beta (Aβ), and α-synuclein (αS)—linked to type 2 diabetes (T2D), Alzheimer's disease (AD), and Parkinson’s disease (PD), respectively, the project builds on recent discoveries made by the consortium. These findings highlight the critical role of free lipids in membrane damage through the formation of stable lipid-amyloidogenic protein complexes, leading to the lipid-chaperone hypothesis.The project will explore unresolved mechanisms linking amyloid aggregation to cellular damage, focusing on three key aspects: 1) the toxicity of prefibrillar amyloid oligomers, 2) the interaction of amyloid proteins with lipid membranes, and 3) the pathological spread of amyloid aggregates in the brain. Guided by the lipid-chaperone hypothesis, the consortium will train fifteen Doctoral Candidates (DCs), emphasizing the pivotal role of lipids in amyloid-related diseases. The training program will include cutting-edge methods in biophysics, peptide chemistry, molecular and structural biology, and cell biology.The scientific objectives of LIPAGG include characterizing amyloid-lipid complexes, understanding their impact on aggregation and membrane integrity, assessing their effects on cellular viability and intercellular spread, and developing chemical tools to block the formation of these complexes, offering potential therapeutic strategies. The results will have significant societal impact, enhancing our understanding of AD, PD, and T2D, including potential improvements in diagnostic and therapeutic approaches. With support of a c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Greater Operating Temperature Alloy'.

assistant: **Concept**

The objective of Greater Operating Temperature Alloy [GOTA] will be to select a titanium alloy capable of being fabricated into intermediate compressor casings, and enduring operating temperatures of at least 500 deg C in this service. Industrial manufacture of the selected alloy will be demonstrated, by the production of rolled rings; gravity cast and centrifugally cast samples; sheets, welding wire, and welded samples.•TIMET UK Ltd., [TIMET] will be the Principal Participant, and will lead the Management of the project.•Swansea University will lead the review of literature and prior industrial work. A candidate alloy (Ti+) will be selected based on this review, and on commercial and industrial factors.•TIMET will supply Ti+ billets to Forgital Italy S.p.A. which will manufacture, heat treat, and sample rolled rings.•TIMET will supply Ti+ casting stock to Deritend International, which will manufacture stepped section cast samples by both gravity and centrifugal casting, aiming to overcome the prior low ductility reported in castings of highly creep resistant titanium alloys.•TIMET will manufacture sheet; welding wire, and welded samples of the Ti+ alloy. Significant process development work is required in this task.•Swansea University will test the samples of the candidate to generate a database of mechanical properties for this titanium alloy in cast, wrought and welded forms and analyse the samples to rationalise the test results.•The tests will consist of tensile; creep; LCF; and fatigue crack propagation tests at both room temperature and 500 deg C. Also, tensile tests will be repeated after exposure to air at 500 deg C for extended time period, to check for deterioration in ductility.•TIMET UK Ltd., will lead the reporting of the project, and the Participants will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HEALTH AND SAFETY PROMOTION IN THE EUROPEAN UNION', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

HSPRO-EU will develop a remotely accessible telematics system to promote information on health and safety at the workplace in line with current legislation, particularly in small and medium-sized enterprises (SMEs). The project will aim at a universally accessible system matching user needs, with special concern for firms insufficiently active in this area. Implementation will last some two-and-a-half years. The operational effectiveness of validated sites for the system in four countries will be reviewed prior to its amendment and wider use by the end of that period.The project will develop a remotely accessible telematics system which will provide a range of health and safety and workplace health promotion information. Its focus will be particularly directed at meeting the needs of SMEs with respect to current legislation. The objectives are: - to develop a health and safety information system based on representative user needs which is capable of being accessed by all enterprises;- to stimulate increased occupational health and safety promotion activity among previously inactive or sub-active enterprises. Anticipated results are: - by month 12 to have a validation site using the system in each participating country; - by month 17 to have achieved sufficient implementation in the test bed sites enabling a review of the usage of the system so as to establish its efficacy and efficiency; - by month 27 to have developed an amended system; - by month 30 to encourage widespread use of the system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dicer-Dependent Defense in Mammals' to be submitted under Horizon 2020.

assistant: **Abstract**

Viral infection or retrotransposon expansion in the genome often result in production of double-stranded RNA (dsRNA). dsRNA can be intercepted by RNase III Dicer acting in the RNA interference (RNAi) pathway, an ancient eukaryotic defense mechanism. Notably, endogenous mammalian RNAi appears dormant while its common and unique physiological roles remain poorly understood. A factor underlying mammalian RNAi dormancy is inefficient processing of dsRNA by the full-length Dicer. Yet, a simple truncation of Dicer leads to hyperactive RNAi, which is naturally present in mouse oocytes.The D-FENS project will use genetic animal models to define common, cell-specific and species-specific roles of mammalian RNAi. D-FENS has three complementary and synergizing objectives:(1) Explore consequences of hyperactive RNAi in vivo. A mouse expressing a truncated Dicer will reveal at the organismal level any negative effect of hyperactive RNAi, the relationship between RNAi and mammalian immune system, and potential of RNAi to suppress viral infections in mammals.(2) Define common and species-specific features of RNAi in the oocyte. Functional and bioinformatics analyses in mouse, bovine, and hamster oocytes will define rules and exceptions concerning endogenous RNAi roles, including RNAi contribution to maternal mRNA degradation and co-existence with the miRNA pathway.(3) Uncover relationship between RNAi and piRNA pathways in suppression of retrotransposons. We hypothesize that hyperactive RNAi in mouse oocytes functionally complements the piRNA pathway, a Dicer-independent pathway suppressing retrotransposons in the germline. Using genetic models, we will explore unique and redundant roles of both pathways in the germline.D-FENS will uncover physiological significance of the N-terminal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PROGRESSING PROMISING SKILLS TO WORK IN BULGARIA (PROSKILLS2WORK)' (PROSKILLS2WORK) under Horizon Europe.

assistant: **Objectives**

The main goal of ProSkills2Work is to raise the international research visibility of the Institute of Philosophy and Sociology (IPS) of the Bulgarian Academy of Sciences and to develop its traditionally strong focus on sociology of education and work towards a world-class level of research excellence. This will be achieved by advancing scientific knowledge on the Bulgarian vocational skills formation system, continuous skills enhancement, individual transitions from education to work, and workplace learning, alongside the respective methodological challenges. The project's research component will advance scientific knowledge by further developing sociological concepts which allow for analysing the complex relationship of education and work in the current societal and economic context of Bulgaria. Five specific objectives will guide the implementation of ProSkills2Work: 1) Appointment of Prof. Dr. Christian Imdorf to establish and lead the ERA Chair research unit; 2) Develop the research and innovation capacity of the IPS towards international excellence; 3) Ensure the constant development of various skill sets and competencies among IPS researchers; 4) Implement structural changes to create the conditions to achieve research excellence on a sustainable basis; 5) Position the IPS as a hub for scientific excellence and policy-relevant stakeholder exchange on progressing promising skills to work through the institutionalisation of a future Bulgarian Observatory of Education and Work. The increase of research capacity at IPS by the ERA Chair unit is expected to promote collaborations between research teams in the IPS and external research groups, as well as translating research results into policy recommendations and innovative models of vocational skills formation in Bulga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Accelerating HIV Cure in Europe' under Horizon 2020.

assistant: **Concept**

Finding a CURE for 35 Million individuals living with HIV/AIDS is one of the great global health challenges of the 21st century. The major obstacle to HIV eradication is the persistence of latent HIV cellular reservoirs, where the integrated viral genome is transcriptionally silenced but replication-competent and can escape both Anti-Retroviral Therapy and Immune Responses. The development of novel strategies aimed at eliminating these reservoirs have become paramount in HIV research, if we want to achieve an HIV/AIDS CURE. To accelerate the State of the Art in HIV CURE research in Europe, our EU4HIVCURE consortium brings together an intersectoral and interdisciplinary collaboration between 3 Universities, 3 Hospitals, 1 International Research Organisation from 4 European countries and 1 University from Canada. Our aim is to dissect the intricate mechanisms controlling HIV-1 latency and identify new druggable targets to develop novel latency-reversing strategies and eradicate persistent viral reservoirs by forcing HIV-1 gene expression. To facilitate continuum for translation to the clinic, we have developed an operational framework, which maximises exchange of knowledge and expertise via secondements, networking and training activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'DO BEAVERS NEGATIVELY IMPACT THE ATLANTIC SALMON AND SEA TROUT RESOURCE?'.

assistant: **Innovation**

Atlantic salmon (Salmo salar) and sea trout (Salmo trutta) are an important economic, recreational, and ecological resource in the European Atlantic and Baltic seaboard, from northern Norway to Portugal. In economic terms, the worth of a single salmon and a single sea-trout has been assessed at €4273 and €593. The salmon and sea trout fishery on the River Spey alone contributes €13.5 million to household incomes annually. Eurasian beavers (Castor fiber), once largely extirpated in Europe, are now recolonising the salmon and sea trout range. Though beavers represent one of the major success stories of modern European conservation, their return to rivers holding economically and socially important salmon and sea trout resources is of concern because beaver dams can block fish movements, especially migrations to breeding grounds, and remove freshwater habitat. By altering the habitat use, survival, and growth of these fishes beavers may impact fish production. Although the potential for beavers to influence salmon and sea trout is very high, this phenomenon is largely unstudied in Europe leaving a knowledge gap for management of growing beaver populations. We propose to conduct a thorough study addressing this European scale knowledge gap based in Norway, through research and transfer of skills by an experienced N. American researcher which will create long-term collaborations. Norway is currently unique in having both an anadromous salmonid population of major economic and social importance, and a large Eurasian beaver population. The fellowship will bring a researcher at the forefront of her field (studying the impact of N. American beavers on Pacific salmon) to Europe, where many scientists will benefit from her knowledge of the field. This project is timely due to the