RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cell Targeting by Murine Recombinant Retroviruses' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and contentThe objective of my thesis project is to develop efficient techniques for cell targeting by recombinant retroviruses derived from the Moloney murine leukemia virus. These vectors are currently the most widely used in the gene therapy protocols. However, their use is, at the moment, restricted for the genetic modification of dividing cells in culture, to be used in ex vivo protocols. One of the major limitations of the retroviral technology is the lack of cell targeting techniques. The ability to selectively infect predetermined target cells, of high therapeutical value, would open the doors for a number of clinical and basic research applications.Most importantly:1) it would improve the current yields of gene delivery in under-represented cell types, like early hematopoietic progenitor cells, thus improving gene therapy efficiency.2) it would open the possibility for in vivo gene therapy, thus dramatically reducing its COSt and labour required at present3) it would provide to researchers a valuable tool for creating animal models for human diseases as well as models of carcinogenesis and animal development4) ability to target tumour cells could be used as a surveillance treatment to prevent metastasis, by delivering +suicide genes, selectively into tumour cells.My thesis work is based on the modification of the envelope glycoprotein of Moloney murine leukemia retrovirus, which is the principal determinant of the retroviral host range. The modifications to be introduced will be such to enable the recombinant retrovirus to select and infect cells through the recognition of novel cell surface markers. My specific aims will be two-fold. In a first step, I will improve the in vitro cell targeting technology, using cultured cell lines.This will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New science for European ps time-resolved Laue X-ray diffraction' in the context of a Seventh Framework call.

assistant: **Objectives**

I pursue the study of molecular reaction dynamics of biomolecules mostly in the non-coherent time-regime using spectroscopic and X-ray structural techniques. In recent years, breakthroughs in the field of pump-probe X-ray crystallographic structure determination of reaction intermediates of light-sensitive proteins have generated much excitement. These experiments provide insight of key Biological importance and marry structural observations with spectroscopic studies to understand molecular reactivity. My work focuses on the light-sensitive proteins in particular to provide structural dynamics understanding of photoreactions and Biological signalling. The European Synchrotron Radiation Facility is investing in this area, providing and integrating technology that has been developed for pump-probe experiments using the pink-Laue technique in new designs for an upgraded and advanced beamline at ESRF. Historically, research groups in the US have dominated this field and the recent commissioning of the Biocars pump-probe beamline 14-ID-B at APS which has capabilities similar to ID09B at ESRF shows that international competition is strong. While technical capabilities of these two sources have rapidly developed, there has been an obvious lag in applications for the methodology. So far, photolysis of heme proteins (myoglobin-CO and recently FixL) and a photoreceptor molecule called Photoactive Yellow Protein (PYP) have been targets for pump-probe experiments. Clearly it is of strong strategic importance for European science to compete in this area. I have invested four years to develop the Green Fluorescent Protein as a new application, focussing on both time-resolved Laue diffraction as well as ultrafast vibrational and visible spectroscopy to characterise structural dynamic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Flow of complex fluids in porous media'.

assistant: **Concept**

This project will enable the fellows to perform quality research in resolving the problems of fluid placement into heterogeneous rocks. They will benefit from a team environment where scientists of different nationalities and domains work together. They will also be encouraged to interact with experts in sister Schlumberger Research and Development centres in Europe and the U.S.A.The project will be carried out in an industrial environment characterised by a reputation for scientific excellence; hence the fellows will benefit from exposure to issues involved in the applying fundamental research ideas towards the development of innovative, commercial concepts and products. The centre has close links with both Universities (in particular Cambridge University) and also industrial research labs such as the IFP.The fellows will also benefit from the technical challenges posed by the flow of complex fluids through porous media, and broaden their scientific expertise in an area that is economically promising. The company will benefit from the research expertise and the input of fresh ideas from the fellow. The understanding generated by this project will be invaluable for the future development of processes that require the placement of complex fluids into heterogeneous reservoir rocks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Evidence-based risk management in global software development projects'.

assistant: **Concept**

This proposal is to enable Professor June Verner, who is recognised as a leading researcher in project failure, global software engineering and project management, to work with the leading internationally recognized research group in evidence-based software engineering at Keele University. The project will produce a set of guidelines to assist project managers in the identification of risks relating to global software development (GSD) and to recommend ways in which the risks can be addressed, minimised or mitigated within different project contexts, based upon high quality empirical evidence. The project will also deliver a software tool for use by GSD project managers. The project will therefore reduce the high failure rate of GSD projects. Essential to the success of the project is the training of both the research fellow and the project team at the host institution. The project will facilitate the transfer of invaluable knowledge relating to GSD and its associated risks to Europe and form the basis of a long-term collaboration between the researchers. In addition, the research fellow will receive training in evidence-based software engineering techniques, including systematic literature reviews, which can be used within teaching and research, and also benefit software practice in Australia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'VALIDATION OF A NEW GENERATION 250 KW WIND FARM FOR WEAK GRIDS' to be submitted under Fourth Framework.

assistant: **Abstract**

To demonstrate the competitiveness and to improve the reliability of a new generation of wind turbines of unit powers of 50 kW, the first of which has been constructed. More precisely, the objective is the implementation of technically simple wind turbines, of increased powers and improved performances, whilst rationally controlling their integration into weak grids, to reduce: investment costs, recurrent maintenance costs, technical level of the installation and maintenance personnel.With a measured (over 10 years) annual average wind speed of 8 m/s, the GEV 14.50 with carbon fibre blades will have an average power output of 20,2 kW or 858 215 kWh for the five turbines. The real payback (based on costs to the local community is 3,8 years, realised payback to the Chateau Lastours will be 11,6 years for a wind turbine design lifetime of 20 years.Justification:At the beginning of the 80s, wind turbine technology was in its first stages and the largest wind turbines in construction were between 20 kW and 100 kW. Since then, technical progress has been made in the direction of cost-effectiveness and more powerful turbines, reaching today unit powers of 1,5 MW. These turbines need a high technological environment and strong electricity grids to operate.However, throughout Europe and further afield, there are many islanded and weak grids, of lower powers, where only a technology of appropriate power and technically more independent can deliver a truly economic service. A wind farm of a number of units of 50 kW is in many cases a viable and indeed a rational solution.Innovative dimension:This generation of wind turbines is based on the VERGNET technology which has shown its worth ever since the take-over of the AEROWATT technology, with improvements in simplicity and reliabili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Model-based engineering of Digital Twins for early verification and validation of Industrial Systems', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Thanks to the advances in information technology, modern industrial systems are becoming increasingly intelligent and autonomous;thus their requirements for, e.g., correctness, availability, traceability and reliability, are also increasing. Monitoring, analysis anddiagnosis of such industrial systems became pivotal and fueled the development of virtualization and simulation solutions such asdigital twins.In a nutshell, digital twins are virtual representations of actual systems or processes that serve as real-time digital counterparts for,e.g., prediction, analysis, testing, and simulation. Developing digital twins is a complex process. On the one hand, it includesdeveloping digital twins at different levels of abstraction of the system to allow one to focus on different relevant aspects (e.g,behavioural, logical, physical). On the other hand, it must ensure the correctness of digital twins with respect to the systemspecifications and the respective level of abstraction, and the federation enabling the communication between digital twinsconceived as exchange and resume of models.This project aims to develop a model-based framework addressing the above-mentioned challenges by i) automating the creation ofdigital twins for the simulation, monitoring and testing of functional and non-functional properties ii) continuous validating digitaltwins to meet the required properties and iii) developing a multidomain and automated digital twin toolchain for the verification andvalidation of complex industrial systems based on digital twins. We foresee that this project will positively impact the efficiency ofsuch systems by reducing their time to value and by increasing their final quality.


**Keywords:** Digital Twin, Digital Industry, Model Based Engineering, Runtime Verificati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The microbial and physico-chemical degradation of bone as an indicator in the deterioration of the European archaeological property'.

assistant: **Innovation**

The study of archaeological bone, both as animal and human skeletal remains, and as worked objects, provides a wealth of information about the people of our past and the way they lived. Unfortunately, bone is subject to degradation. Moreover, field archaeologists in several countries have evidence that the quality of ancient bone is much worse if compared with material recovered from similar soil and climatic conditions many years ago. In addition, to the natural process of degradation, industrialization and agriultural practices apparently have cause world-wide dramatic changes in the soil environment of archaeological remains and the implications for our cultural heritage are all too clear. Unfortunately, current understanding of the processes of acidification and oxidation of the soil are not sufficiently advanced for specialists in the field of cultural heritage management, which hinders adequate measures. This has already has led and still leads to a tremendous loss of archaeological information. It is clear that insight into this pan-European evironmental problem only can be achieved by multidiscipllinary research involving and integrating a variety of science-based techniques present at various laboratories within and outside the field of archaeological heritage management. The main issue of research will be the effects of environmental acidification on bone in a well-defined and carefully selected number of archaeological soil conditions in Europe. This will lead to: - the establishment of the relevant bone degradation mechanisms; - an assessment of the limits, benefits and appropriate application of used methods, both with respect to future research and the definition of preservation measures; - transfer of the results to archaeological heritage management and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative Nutraceutical Strategies for Enhancing Organic Quail Farming: A Focus on B Vitamin Supplementation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The growing demand for organic poultry, particularly chickens, presents a challenge for the industry to offer sustainable alternatives while ensuring animal health under less controlled organic conditions. Organic quail farming emerges as a viable option, but the absence of controlled environments makes quails more prone to health and productivity issues. Nutraceuticals like B vitamins offer a promising solution, yet no studies have determined the optimal supplementation levels for organic quails under these conditions. OrganiQ addresses this by investigating the effects of thiamine (B1), pyridoxine (B6), and cobalamin (B12) to improve quail growth (WP1), physiological responses (WP2), gut microbiome dynamics (WP3), and meat and egg quality (WP4). The goal is to identify the ideal dosage and combination of these vitamins to boost productivity, health, and product quality in non-controlled environments. Using an interdisciplinary approach that integrates animal production, microbiology, bioinformatics, and food science, I aim to develop evidence-based dietary recommendations for organic quail farming. Selçuk University, known for its expertise in avian production and led by Prof. Olgun, provides the perfect environment for this research. Additionally, secondments at the University of Salamanca and Estación Tecnológica de la Carne will enhance my skills in microbiological and meat quality analysis while further developing my leadership capabilities. OrganiQ will equip me with practical experience and interdisciplinary knowledge, preparing me to manage multidisciplinary teams and pursue European funding opportunities, ultimately enabling me to establish my own research group in sustainable animal production.


**Keywords:** B Vitamin Supplementation, Quails, Organic Avian
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Optimal High-Lift Turbine Blade Aero-Mechanical Design' (ITURB), addressing dissemination and exploitation.

assistant: **Impact**

The need for high speed low pressure turbine modules to be used with innovative aircraft engine concept establishes critical mechanical constraints with very high hub stresses for the rotor blades, thus representing a real challenge for the design. In order to assist the designer with reliable tools it is mandatory to assess the performance of turbine rotor blades of innovative concept with both numerical and experimental investigations.Starting from a baseline configuration, representative of the state-of-the-art of LPT high-lift rotor blades, an aerodynamic optimization will be performed exploiting modern optimization techniques. These techniques are based on the coupling between fast and flexible parametric handling of the geometries, CFD computations and meta-models like Artificial Neural Networks (ANN) or Radial Basis Functions (RBF). Such an approach will accomplish a multi-objective design aimed at enhancing the aerodynamic performance while meeting mechanical and geometrical constraints.Tests will be performed on both baseline and optimized rotors within a cold-flow, large-scale laboratory turbine. Tests on turbine configuration will ensure the reproduction of the correct radial equilibrium effects as well as of the rotor-stator aerodynamic interaction. The Reynolds number will be investigated in the range between 50000 and 300000, which represents the operative range of the LP rotor blades of the engine. The large scale of the facility will allow detailed aerodynamic investigations, and an accurate performance analysis.The numerical and experimental frameworks will allow one to validate and verify the optimized solution and to highlight the key features of the new design with respect to the baseline. The  validation of the design and optimization procedures wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Redefining Tsetse symbiont bacteria: A Trojan horse against Trypanosome transmission'.

assistant: **Innovation**

African trypanosomiasis has been a historic scourge on the African continent and one of the major causes of poverty. It is responsible for sleeping sickness in humans and it avoids the development of agriculture based on domesticated animals where it causes Nagana. It is a neglected disease with the worst drug control according to WHO. In this project, I propose a conceptual change in the therapeutic approach against Trypanosoma sp., being the goal of the proposal to eliminate the parasite in its vector, the tsetse fly, thus fighting both, sleeping sickness and Nagana. Taking advantage of the current methodological advances, the claim of this innovative proposal is the design of a new expression system to reduce or eliminate the vector competence, using for it one of the endosymbionts of the fly, Sodalis sp. The development of this idea involves a work of entomology, microbiology, parasitology and molecular biology. For this study, 2 research groups with solid and complementary expertise and skills are required: The French National Research Institute for Sustainable Development (France) and the University of Groningen (The Netherlands). The methodology implemented in this project will be: (i) characterization of proteins secretion pathways in Sodalis for heterologous expression of peptides, (ii) identification of promoters overexpressed in Sodalis upon interaction with Trypanosoma, and their characterization by fusion to fluorescent proteins, iii) paratransgenesis assays in flies and evaluation of the in vivo activity in infected and non-infected flies, stability across time and inherency to progeny, iv) analysis of the vector competence, using the new expression system by the production of antimicrobial peptides active against Trypanosoma, production of insecticidal pe