RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neutralizing antibodies on Interferon beta in Multiple Sclerosis' (NABINMS).

assistant: **Concept**

Nearly all biopharmaceuticals induce antibodies. Although the impact of these antibodies varies widely, it is clear that the immunogenicity of biopharmaceuticals may hamper optimum treatment strategies. The effectiveness of interferon beta (IFNb) is well established in relapsing-remitting multiple sclerosis (MS). Nevertheless, the use of this drug in clinical practice is complex, especially because it may induce neutralising antibodies (NABs). These NABs cause a reduction in IFNb bioavailability as measured by reduced levels of biomarkers. Moreover, there is evidence that persistent NABs reduce therapeutic efficacy. Because a standardised assay is lacking, the relevant clinical and biological level of NABs has not yet been defined. We here propose to setup a European wide network to provide standardised testing and to define the titres which are clinically relevant. We also want to develop in-vitro and in-vivo assays and models that predict immunogenicity, allowing strategies to prevent or modulate the induction of NABs. This project will increase the efficient use of IFNb in MS and safe money (approximately 100 million Euros per year) for the EU health systems by avoiding the use of this expensive treatment in patients in whom the drug is not effective. We want to achieve these goals by: 1 Validation and standardisation of a recently CHMP approved common assay for the detection of NABs. 2 Developing new assays. 3 Evaluating clinical effects in large cohorts of patients. 4 Studying bio-activity markers. 5 Studying immunogenicity. This research may lead to an evidence-based approach for dealing with the clinical problems of NABs and to improve care of MS patients by deciding what a clinically significant level of NABs is and recommending a strategy that will reduce clini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dypha: adding the dimension of time to cell culture' (Dypha) under Horizon Europe.

assistant: **Objectives**

The current preclinical drug development pipeline is highly inefficient with 9 out of 10 drugs failing when first tested in humans. Of those failures, between 69% and 81% is due to a lack of efficacy (52-57%) or safety (17-24%), indicating that the predictivity of currently used cell culture and animal models is not high enough. While promising human cell culture models have arisen in the last decades (e.g. pluripotent stem cell models, spheroids, organoids), the environment of these models is too simplistic to reach their full potential and to translate certain responses to humans. One of the important aspects missing in current cell culture is kinetics: many processes in the human body have response times with resolutions of seconds, minutes or hours. In standard cell culture however, such temporal resolution is absent because cell culture medium remains unchanged for typically 1-3 days. So for kinetics, scientists turn to animal models with relatively low translational success and high costs. As an alternative, complex microfluidic setups have been used to enable perfusion in vitro and demonstrated a significant amount of evidence that kinetics can improve the relevance of cell culture models. Despite the evidence, typical cell culture biologists are not taking kinetics into account because the tools to control kinetics in cell culture are too complex.We solve this problem by starting from what cell culture biologists currently use: a standard well plate. We developed a Fluidic Adaptor that can be clamped on any 96 well plate and completely replaces the fluid in the well homogenously without disturbing the cell culture. Our goal is to develop a plug-and-play peripheral system that integrates automated fluidics and microscopic readout in a fully controlled environment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Public Procurement of Innovative Solutions for High-Performance Computing' under Horizon 2020.

assistant: **Concept**

In its communication on the “European Cloud Initiative” the European Commission in April 2016 stressed the need for building an European Data Infrastructure including high-end supercomputers, which will around 2022 reach the exascale performance level. In this proposal, a group of leading European supercomputing centres propose the formation of a buyers group to execute a joint Public Procurement of Innovative Solutions (PPI) in the area of high-performance computing (HPC). The co-funding by the European Commission (EC) will allow for a significant enhancement of the planned pre-exascale HPC infrastructure from 2018 on. The total investment is planned to be about € 73 million.The involved HPC centres, namely BSC, CEA/GENCI, CINECA and JUELICH, have a strong track record in providing supercomputing resources at European level. The project participants are founding members of PRACE and have made Tier-0 systems available through PRACE.This joint initiative will create benefits in multiple respects:▪ More supercomputing resources will be efficiently exploitable for science and engineering applications in Europe within PRACE, the pan-European HPC infrastructure, as selected, relevant applications will play an important role in guiding this procurement process.▪ R&D on HPC architectures and technologies in Europe will be strengthened as suitable incentives will be provided by this joint procurement process.▪ The coordinated approach will give us a greater weight and allow having more impact on the design of the solutions according to the need of scientists and engineers in Europe.The participants will work together on coordinated roadmaps for providing HPC resources optimised to the needs of European scientists and engineers. The final decision on which innovative solutions w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Water resources management in a changing environment: the impact of sediment on sustainability' (1994-1998).

assistant: **Concept**

The efficient and sustainable management of water resources is dependent on water storage, most often in the form of reservoirs. This is especially true indensely populated areas such as Europe. Much of the water used in lowland are as originates in the mountains as rain and snow, and is trapped as it flows downstream. Along with the water, sediments are also trapped in reservoirs, reducing the effective storage of water and sometimes causing water quality problems. The supply of sediments to reservoirs is determined by a complex mixture of terrestrial and climatic features that make sediment yield estimation difficult. This project brings together experts in modem field techniques, GIS mapping, soil erosion, sediment transport and hydrological modelling to address the problem of reservoir sedimentation and the effects this will have on water resources management under changing environmental conditions. Both future climate and land use change scenarios will be considered and their implications for water resource management and reservoir operations assessed. Three contrasting field areas, where sedimentation is a problem, and base data sets are already available, have been selected for this study. - Northumbrian Water area in North-East England (Fontburn and Cow Green) - the Aragon catchment in the Spanish Pyrenees - the Enns catchment in the Austrian Alps.In the first two areas the local water authorities are acting as sub-contractors of the project, in the third a statement of support from the local water-power company has been obtained. In all three areas the study will identify sediment source areas and their connectivity to the river network, through GIS mapping and the use of GPS and tracers such as caesium-137. This information, together with meteorological and ri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Eigenvalue optimisation and Minimal surfaces'.

assistant: **Objectives**

This project is positioned on the interface between spectral theory and geometric analysis, and is concerned with the relation between certain analytic invariants of objects (called spectra) and the shape (or geometry) of these objects. A classical example of a spectrum is a Laplacian spectrum. It is a sequence of numbers encoding the information about many physical properties of an object such as elasticity, heat and sound propagations and many others. Specifically, this project deals with the geometry of special shapes such as soap films. The geometry of soap films (the so-called minimal surfaces) is a central subject of modern geometric analysis with applications far beyond the one suggested by their name, most prominently to topology and theory of general relativity. More precisely, the project is devoted to the study of two classical topics: sharp inequalities for eigenvalues of geometric operators on manifolds and minimal surfaces. The underlying principle of the field is the correspondence between minimal surfaces and optimal metrics for such inequalities. This correspondence is both a source of many fascinating intradisciplinary connections (e.g. with analysis, geometry, algebra and theory of integrable systems) and a powerful methodological  tool. A variety of methods from across mathematics  can be applied to this problem and recent advances have resulted in a resolution of several classical problems on either side of the correspondence. The present project aims to build on this success story by targeting long-standing conjectures in the following directions: 1) Using the correspondence to construct many novel examples of minimal surfaces, study their geometry, and look for new patterns and phenomena; 2) Applying methods of geometric analysis to find sharp eig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'New system for the reduction of germs, bacteria and odd substances in the transformation of vegetable products into dehydrated and ready-made food'.

assistant: **Innovation**

ABSTRACT In the industry of viable dehydrated products, the current processes used for the reduction of the bacteriological load (boiling, whitening) in certain products with a high microbial level (due to the fact that they are born under the ground), are inefficient since they alter their organoleptic characteristics and their molecular structure. As a final objective of this project, it is intended to obtain a new procedure for the production of dehydrated vegetables with a total count of less than 100.000 germs in plaque. This new procedure would range from the field work, at the month of harvesting, to the processing work, introducing technological improvements in the harvesting machines, as well as in parts of the processing, washing and whitening lines. Causing a thermo effect in the fresh product before its dehydration, which would affect the critical points where the microbiological contamination is higher, would do this. This should not affect any organoleptic parameter in the final product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Wireless atm network demonstrator' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The project has three main objectives;to specify a wireless, customer premises, access system for ATM networks that maintains the service characteristics and benefits of the ATM networks to the mobile user;to promote the standardisation, notably in ETSI, of wireless ATM access as developed in this project; andto demonstrate and carry out user trials with the selected user group and test the feasibility of a radio based ATM access system.The main result of the project will be a Wireless ATM Access Network Demonstration system which will serve as a proof of concept for the developed technology and help the wireless ATM standardisation work in the relevant fora.The current achievements of the project include the complete functional system specification on the demonstrator which has been specified with the SDL (Specification and Description Language) and verified with the simulation model. In addition, the project has defined the exact demo platform setup and therefore enabled the basis for the implementation work which has been started on all parts of the system.Besides demonstrator work, the project has been active in its liaison and standardisation activities. The stochastical radio channel model for channel simulations was developed and verified by measurements on 5 and 17 GHz frequency bands. The model has been given as an input e.g. for SIG1 work. Furthermore, the project has been active in the standardisation fora by contributing and harmonising the work between ATM forum and ETSI RES10.The Magic WAND project will continue the work on gaining knowledge on the wireless ATM radio design and its medium access control functions as well as wireless ATM specific Control and Signalling functions. These results will be further contributed to ETSI and ATM forum in order to in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'TALENT4RURALSCIENCE Scientific talent for the promotion of rural development'.

assistant: **Objectives**

Rural development and talent retention have become key priorities in European policies. These policies seek to mitigate the depopulation of rural areas and promote their economic and social sustainability, recognising the importance of rural areas for territorial cohesion, balanced economic development and the preservation of cultural and environmental heritage.The EU Long Term Vision for Rural Areas (2021-2040) reinforces this trend, committing to making rural areas more attractive to young and skilled people by creating infrastructure, access to digital services and employment opportunities. However, talent retention, especially among young people with higher education, remains one of the biggest challenges in the EU's rural areas, affected by problems such as depopulation and ageing populations, particularly in peripheral areas of countries such as Spain, Italy, Greece and Eastern European countries.The TALENT4RURALSCIENCE project emerges as a tool to promote rural development and talent retention, with an international and cross-sectoral dimension. This programme seeks to attract 10 postdoctoral researchers of any nationality through an open international call, to develop innovative R+D+i projects focused on the intersection between rural development and talent retention.The project will involve 9 research institutes of the University of Extremadura, addressing three key challenges: 1) Sustainable development and natural resource management, 2) Innovation in health and technology for rural development, and 3) Education, inclusion and community development. TALENT4RURALSCIENCE will be supported with the participation of 9 associated partner organizations (7 Universities, 1 department of public administration, 1 clinical research centre of public health care system) f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Pulmonary Hypertension: Functional Genomics and Therapy of Lung Vascular Remodelling'.

assistant: **Concept**

Pulmonary hypertension (PH) describes devastating diseases, comprising idiopathic and secondary forms, which cause breathlessness and premature death, representing a major burden on healthcare systems. Extensive lung vascular remodelling with loss of vessel patency is the underlying pathomechanism. PULMOTENSION integrates the top EU Centres in PH and lung vascular biology in a multidisciplinary approach, aiming to combat and finally cure PH. The expertise of all members extends from the initial discovery of gene mutations causative of PH to having established new therapeutic regimen of PH. We will uncover underlying molecular pathways, identify distinct targets for anti-remodelling therapy, foster drug development based on these targets, and test these new treatment options in preclinical and clinical trials. The presented project includes a) genetics of PH, b) functional genomics and proteomics to unravel the molecular pathways underlying vascular remodelling, c) characterisation of the cross-talk between different cells and signalling pathways involved, d) preclinical trials in PH models including transgenics, e) a European PH Tissue Bank and Registry, f) conversion of target discovery into drug design and exploitation, g) development of non-invasive clinical tools for monitoring lung vascular remodelling in patients, h) a Clinical Trial Network to conduct phase I/II(III) studies focussing on anti- and reversal of remodelling in PH patients, and i) promotion of a world-leading infrastructure for scientific and technical competence in the field of PH, including training and mobility programs, technology transfer in alliance with industry and exploitation facilities. Gender issues will be particularly addressed, as many PH forms have a female preponderance. Hence, this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The legal and institutional factors shaping New Modes of Governance (NMGs) in regional economic policy contexts: The cases of Spain and Romania' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This research project analyses the legal and institutional factors bearing upon the emergence and functioning of new modes of governance (NMGs) in economic policy contexts at territorial/regional level in Spain and Romania.For the purposes of this project, NMGs are understood as non-hierarchical forms of coordination between public and private actors in economic policy-shaping and implementation.The project applies an interdisciplinary research approach, combining comparative legal analysis with theoretic al perspectives and empirical research tools borrowed from the political sciences.In terms of research output, the objective is to identify and discuss the legal and institutional factors (at EU, national and territorial/regional level) that obstacle the emergence and functioning of NMGS in regional policy contexts, and to discuss modalities for allowing and enhancing synergies between 'old' and 'new' modes of economic governance at territorial/regional level.The project examines the Spanish and Romanian frameworks and experiences in the context of three related EU economic policy areas: EC cohesion policy, Community support for rural development, and the European Employment Strategy.The analysis is structured on two dimensions: at the EU level, the project examines how the characteristics of the acquis in each of these policy areas (in terms of 'constitutional' basis, mix of 'hard' and 'soft' methods and instruments, etc.) influence upon the emergence and functioning of NMGs at territorial/regional level.On the national dimension, the project examines the domestic constitutional, legislative and institutional factors that bear upon the mix of 'old' and 'new' modes of economic governance at territorial/regional level.