RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A microfluidic chip for non-invasive, early detection of pancreatic cancer – liquid biopsy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Pancreatic cancer is the fourth-leading cause of cancer related mortality and is predicted to be the second leading cause of cancer death by 2030. Widely regarded as a death sentence, the 5-year survival rate is only 3% in the UK and this figure has not changed over the past four decades due to lack of specific therapies and inability to detect it early. Several years often elapses from the beginning of the disease to the patient’s diagnosis, suggesting a window of opportunity for early detection. Recently, tiny nanometre-sized vesicles (exosomes) shed by the tumour in the bloodstream, have emerged as powerful circulating biomarkers possessing extremely high sensitivity and specificity, thus paving the way for a new era of non-invasive cancer diagnostics. However, currently the process of exosome isolation and detection is not only highly inefficient, but also technically challenging and inaccessible to hospital laboratories, clinical facilities and resource-poor settings. To address technological constraints of exosome utilisation, we are developing a microfluidic device that leverages cutting-edge microfabrication technology to enable isolation and detection of tumour exosomes from the blood for screening and detecting early-stage pancreatic cancer with unprecedented precision. This chip will have two components, a separation module where exosomes will be isolated from all other blood particles, and a detection chamber that will incorporate technology to achieve ultralow resolution.  The first stage of development will be concerned with the fabrication of all components necessary to harness the sensitivity of the exosome biomarker. Following initial testing, we plan to take steps towards commercialisation of the device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Service Oriented Architectures for All'.

assistant: **Innovation**

Computer science is entering a new generation. The emerging generation starts by abstracting from software and sees all resources as services in a service-oriented architecture (SOA). In a world of services, it is the service that counts for a customer and not the software or hardware components which implement the service. Service-oriented architectures are rapidly becoming the dominant computing paradigm. However, current SOA solutions are still restricted in their application context to being in-house solutions of companies. A service Web will have billions of services. While service orientation is widely acknowledged for its potential to revolutionize the world of computing by abstracting from the underlying hardware and software layers, its success depends on resolving a number of fundamental challenges that SOA does not address today.<br/>SOA4All will help to realize a world where billions of parties are exposing and consuming services via advanced Web technology.The outcome of the project will be a comprehensive framework and infrastructure that integrates four complimentary and revolutionary technical advances into a coherent and domain independent service delivery platform:<br/> Web principles and technology as the underlying infrastructure for the integration of services at a world wide scale. Web 2.0 as a means to structure human-machine cooperation in an efficient and cost-effective manner. Semantic Web technology as a means to abstract from syntax to semantics as required for meaningful service discovery. Context management as a way to process in a machine understandable way user needs that facilitates the customization of existing services for the needs of users.<br/>SOA4All is endorsed by the NESSI constituency as an Strategic Project and will contrib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Transport of Spins in Semiconductors' in the context of a Sixth Framework call.

assistant: **Objectives**

A Monte Carlo spintronic device simulator will be developed. This simulator will be the first of its kind taking into account the concurrent action of the D'yakonov-Perel', Elliot-Yafet, Bir-Aronov-Pikus and hyperfine interaction spin relaxation mechanisms . The underlying band structure model for the simulator will be extended to include spin and the relevant spin splittings, and from there the spin dynamics will follow. The Datta-Das and the Resonant Spin Lifetime transistors will be analysed. Other propos als for spin injectors (ferromagnet/tunnel barrier/semiconductor, RTD with dilute magnetic semiconductor well layer, asymmetric RTDs) will be studied, and improved and/or novel designs will result. Since lots of the suggested devices rely on transport with purely quantum effects (e.g. resonant tunnelling, interface properties) in nanostructures, different methods for the computation of the transmission coefficients will be studied. In particular, the performance of the Multiband Quantum Transmitting Boundar y Method will be tested against the Green's function approach. The transmission coefficients (scattering matrices in their general form) completely characterise quantum transport, and they will be used to treat the coupling of the semiclassical and quantum regions in the device simulator.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development and further improvement of a novel resorbable bone cement for clinical applications', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The main objective is to improve the in vitro setting and hardening properties of a new biocompatible amorphous calcium phosphate bone cement with fast bone transformation rate and planning with time the in vivo experiments which are in fact very time consuming. Also, the analysis of the data takes time. In fact, these new biocompatible materials have to be characterised through the contract ERBFMB1CT961621. However, some natural delays have been produced in the development of this work due to the training and know-how transference between the IRC and myself. Also, delays have been produced in the development of some especial measurement equipments of fundamental importance to carried out up to the end the whole research project. It is known that amorphous materials dissolve faster under in vivo conditions and in growth of new bone may also take place faster. Our experience in the development and characterisation of a-Tricalcium Phosphate (a-TC based calcium phosphate bone cements, gained during my PhD Thesis, allows to foresee a good potential for these ideas. At present, the physiochemical mechanisms controlling the setting and hardening properties of these cements are well understood. Moreover, the stability and in vivo behaviour of these cements are correlated with these mechanisms. The resulting ideas suggest that it is possible to control the in vivo behaviour of this kind of cements by the modification of some control factors affecting the powder phase, the liquid phase or the mixture. These seems to be a good possibility to modify the rate of resorption of these cements as well as the rate of new bone formation by adding some additives to the original a-TCP powder. From a previous study we know that one of these additives produces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Strategies for breeding climate change resilient barley, genetically equipped to optimized root-microbiome interactions'.

assistant: **Objectives**

BarleyMicroBreed builds on the paradigm that crop resource efficiency and stress resilience can be significantly improved by optimizing the capacity of plant roots to efficiently interact with the existing soil microbiota. We therefore propose to advance our mechanistic understanding of interactions between the crop plant genome, root phenotypic traits, and the root-associated microbiota to identify novel breeding strategies for crops tailored to harness the benefits of the indigenous soil microbial diversity.A holo-omics analysis of functionally annotated barley genomes together with a catalogue of root microbiota assemblages and phenotypic data including drought responses of 600 barley varieties determined in field trials in Austria, Lebanon and Morocco, will enable the identification of barley genome components, microbiota members and root traits important for drought resilience. Barley genome regions putatively important for microbiota assembly and drought resistance will be validated by gene knock-outs and causative effects will be explored using a combination of metabolomics, metagenomics and root phenotyping in pot and rhizobox experiments.To improve root phenotyping, we will develop tools including core break imaging systems, software developments for “gap filling” in rhizobox phenotyping, and models to infer seedling to mature root system architecture.Finally, with the knowledge of the genetic regulation of phenotypic root plasticity of barley lines we will implement strategies to create drought adaptive barley varieties with improved root systems and microbiomes. A selection of lines based on drought responses, microbiome assembly and root systems will be backcrossed into elite European lines and tested in field trials.We argue that breeding for crops tailored
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Co-ordinating competencies and knowledge in the european automobile system' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The thematic network will analyse the structural changes occurring within the European automobiles system, both in the organisation of production (i.e. the new role of system integrators in upstream activities, the effects of environmental regulation) and in the area of services (non-visible activities). These changes imply the emergence of new competencies and knowledge, and a new configuration of the automobile system: the competitiveness of the auto industry increasingly depends on the efficient co-ordination of competencies and knowledge by the way of inter-firm co-operation. To evaluate these changes, the CoCKEAS network will bring together 13 academic institutions (from 8 European countries) that will share their analyses, debate the new trends and elaborate a common methodology for systematic empirical surveys - including comparisons with the rest of the World.Representatives from industry will be involved in this scientific programme, and the political implications will be identified and discussed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum phases of Fermi-Fermi, Bose-Bose and Bose-Fermi mixtures of atomic gases at ultracold temperatures' (2007-2013).

assistant: **Concept**

The Dr. Iskin will undertake theoretical research in condensed atomic and molecular physics. He will investigate quantum phases of two-species Fermi-Fermi, Bose-Bose and Bose-Fermi mixtures of atomic gases at ultracold temperatures. There are four main problems in this proposal. The first problem is about creating and observing a spatially modulated superfluid phase with characteristics of an Fulde-Ferrell and Larkin-Ovchinnikov (FFLO) type superfluidity in trapped atomic Fermi-Fermi mixtures. The second problem is about the phase diagram of the two-species Bose-Hubbard model, and their observation in atomic Bose-Bose mixtures. Both of these problems are highly popular in the field, and Dr. Iskin has already made a great progress on them. The third problem is about the limiting case of light-atom--heavy-atom mixtures, particularly those which can be described by light-heavy (Fermi-Fermi, Bose-Bose, Bose-Fermi and Fermi-Bose) Falicov-Kimball models. Dr. Iskin will apply the renormalization group theory to all 4 of these models. Finally, the last problem is about heteronuclear molecules, and creation and observation of a new phase of matter, i.e. ferroelectric superfluidity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Uncovering the role and regulation of 3D DNA-RNA nuclear dynamics in controlling cell fate decisions' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

At the onset of mammalian life, the first lineage specification decision is made where embryonic cells opt tobecome either part of the placenta or the future body. Proper regulation of this choice is crucial for subsequentdevelopment. However, we dont know how the transcription program and 3D genome architecture arise,interconnect, and are controlled to determine the fate of each cell in a developing embryo. Recent studies,including my work, suggest that in addition to canonical mRNA-coding genes, RNAs from the dark parts ofthe genome (e.g., transposons, repeats, long-non-coding RNAs) play a significant role during these events, yethow specific classes of RNA regulate gene expression and nuclear architecture post fertilization remainselusive. The main aim of my proposal is to understand the interrelationship between 3D genome organizationand the transcriptome across early development and to identify novel factors that lead to the first cell-fatedecision and concomitant decrease in cell potency.Recent technical advances, which I co-developed, enabled simultaneous measurement of 3D genomeorganization and the transcriptome, and facilitated large-scale functional screens in early mammalian embryos.Thus, I now propose to generate spatiotemporal maps of 3D DNA and RNA organization from early mouseembryos at single-cell resolution (Obj.1) to build a complete picture of the relationships between nucleararchitecture and emerging cell-type specific transcriptome that drive early cell fate choices. I will combinethese data with large-scale in vivo perturbations targeting protein coding genes (Obj.2) and dark genomeRNAs (Obj.3) to identify key inducers/regulators of lineage specification and to determine molecularmechanisms governing cell-state transitions. The proposed research wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Human-specific modifiers of synapses in development, plasticity and disorders'.

assistant: **Objectives**

The function of the brain relies on an intricate network of neurons connected by synapses that enable us to feel, think, learn, act, communicate and adapt our behavior to the ever-changing world. Although the molecular composition and organization of synapses are overall conserved across mammals, a large body of evidence indicates that synapses are differentially regulated in humans. This specialization of human synapses is at the heart of what makes us human. It contributes to the increase in connectivity that characterizes the human neocortex. It also extends the period of synaptic maturation during which cognitive and social experiences sculpt developing cortical circuits and many neurodevelopmental disorders manifest. In this project, we will test the hypothesis that human-specific genetic innovations enhance the role of the environment in the development of synapses in cortical circuits and impact the pathophysiology of neurodisorders. Building on recent advances in our understanding of the human genome, we will determine how human-specific genetic innovations modify the cell biology of synapses, from synaptic connectivity and maturation to synaptic plasticity and pathological dysfunctions. We will combine cutting-edge mouse and human models compatible with investigation of synapse cell biology in integrated circuits together with a multidisciplinary approach based on in vivo molecular manipulations, electrophysiology, microscopy and omics technologies. This will allow us to gain a comprehensive understanding of fundamental mechanisms and illuminate species differences between mouse and human at the synapse and in neurodisorders, in a way not previously possible and with broad implications for the development of therapeutic strategies.


**Keywords:** molecular and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How visual perception shapes our cities: a cognitive model of ageing population' in the context of a Horizon 2020 call.

assistant: **Objectives**

Two mega-trends – the rapid urbanisation of the world’s population and the ageing of that same population – will soon collide. Adapting to the challenges of elderly citizens (many of whom no longer drive), urban designers need appropriate tools to support planning for walking, the most environmentally, socially, and economically sustainable transport mode.  Cities’ walkability depends not only on physical settings, but also on processes of human spatial cognition, in particular visual perception. However, current state of art methods in modelling and forecasting urban systems are based mainly on economic and transportation demands and ignore pedestrians’ spatial cognition. This research discovers how visuo-spatial cognition contributes to the generation of new urban uses and activities based on the age profile of the user population. It constructs a novel urban-behavioural paradigm that links built environment and the way people use it, by addressing three fundamental questions: (1) What are the most important visuo-spatial properties influencing pedestrian cognition? (2) How urban visibility could be encoded and analysed as an abstracted spatial representation (visibility network)? (3) What mechanisms allow cities to be generated through feedback reflected in pedestrian movement and urban visibility? These questions are answered using an interdisciplinary approach: It combines quantitative techniques for spatial modelling with qualitative strategies for tracing of pedestrian behaviour in Immersive Virtual Reality (IVR). The research findings will set a framework for the evidence-based tool to assist planners, architects and stakeholders in the design and evaluation of urban projects in view of the changing needs of urban population.


**Keywords:** spatial cognition, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Improved control and application of nitrogen cycle bacteria for ammonia removal from wastewater (ICON)'.

assistant: **Innovation**

The aim is to develop new applications and control strategies for the sustainable removal of ammonia from wastewater on the basis of the novel process of anoxic ammonia oxidation (Anammox). Application of this new process will ensure and extend the leading position of European waste technology industries. In order to meet recent European discharge standards, research in co-operation with two wastewater companies will focus on the development and optimisation of key parameters (community structure and functioning, biosensors, control models, new conversions). The innovative aspect is the Anammox process, a more energy-efficient nitrogen removal process. Microbiological methods, biosensor development, quantitative flux analysis, and environmental engineering will be improved in a multidisciplinary approach. The main output will be a new type of pilot plant with improved control of nitrogen removal from wastewater.