RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Monitoring cancer stem cell dynamics and therapeutic response in BRCA2-deficient breast tumour cells'.

assistant: **Innovation**

Heterozygous germ line mutations in the breast cancer susceptibility genes (BRCA) 1 or 2 predispose carriers to breast, ovarian, pancreatic and prostate cancers. Significant evidence has accumulated in recent years on vulnerabilities specific to BRCA1/2-deficient tumours, leading to the development of personalized therapies, such as poly-ADP ribose polymerase (PARP) inhibitors. However, tumours develop resistance to these therapies, with tumour heterogeneity and enrichment in cancer stem cell (CSC) sub-population as an underlying resistance mechanism. How the genomic instability intrinsic to BRCA1/2 inactivation impacts on CSC survival and propagation during tumorigenesis and their relevance to the response to therapy has not yet been established. Previous results obtained in the host laboratory show that BRCA2 loss is associated, in the long term (28 days after BRCA2 abrogation), with upregulation of genes involved in metastasis and CSC markers, suggesting BRCA2-deficient cells can acquire metastatic and tumour-initiating capacity. In the current project proposal, we intend to study at single-cell resolution the relationship between CSCs and the response to PARP inhibitors and ionizing radiation (IR) in cancer cell lines and patient-derived xenografts (PDXs) lacking BRCA2 . We will develop a combined single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) experimental approach to characterize BRCA2-deficient CSC subpopulations and to monitor the spatio-temporal dynamics of the CSC signature. This will enable us not only to understand the molecular mechanisms driving cell plasticity in models of BRCA2 inactivation, but also to evaluate the CSC impact on the response of BRCA-mutated tumours to current targeting therapies.


**Keywords:** BRCA1 and BRCA2 g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Disruptive Communication System based on LiFi technology for Spacecrafts and Aerospace Infrastructure' under Horizon Europe.

assistant: **Concept**

Over the next decade, the space industry expects to launch 50,000 satellites in orbit. However, the long-term success of this plan requires substantial cost reductions, explicitly to weight and material costs of satellites. Wired (coppered) signal harnesses are used for data transmission on communication buses within the satellite and account for up to 10% of the total dry mass of a satellite. The high weight, density and complexity of the satellite harnesses represent a substantial pain for manufacturers and an opportunity for innovation and market disruption. Based on feasibility studies with project partners in the space industry, Oledcomm has developed SATELLIFE, the first LiFi (light fidelity)-based wireless connection technology which utilizes light to transmit data. Replacing cables in a spacecraft with SATELLIFE allows a simplification of validation & manufacturing,huge weight reduction and cost reduction.


**Keywords:** Lifi technology,satellite communication systems,Design innovation,wireless communication
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and use of nanoanalytical tools in electron microscopy for the investigation of supported metalic particles of interest in catalysis' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This project is aimed at investigating the deactivation mechanisms in ceria supported noble metal catalysts closely related to the so-called Three Way Catalysts. It will be focused on the High Resolution Nanoanalytical study (EELS) of the catalysts based on (Rh,Pt) / CeLnxOy (Ln = Tb, La) under several treatments. EELS experiments will be used to study the electronic Strong Metal-Support Interaction (SMSI) effect, the occurrence of Metal Decoration phenomena (partial covering of the noble metal crystallites by the reduced support), the formation of intermetallic compounds and direct chemical poisoning effects (presence of chlorine coming from the metal precursor). Supported Rhodium and Platinum from both chlorinated and unchlorinated metal precursors salts will be investigated. The reduction treatments will also be varied in a wide range of temperatures from 623 K to 1 173 K. The Project also considers the study of the chemical nature of the phases resulting from r2 treatment of M / CeO2. Mixed oxide formation (M/Ce) and rhodium and platinum oxidation degree will be studied. Mixed oxide composition unhomogeneity and cation valence state mapping of fine structure will be obtained using EELS. This information will be very helpful to study the redox properties of this new generation of supports used for TWC's catalysts: the mixed oxide. For a succesful development, this project requires the use of High Resolution Nanoanalytical facilities like those existing at the University Paris-Sud. The project would also take advantages of the highly reputated expertise of Dr. Colliex, who on the other hand, has personally been working on M / Rare Earth Oxide Catalysts Systems. This Project would also allow the applicant to improve very significally his current background in nanoanaly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis (EUROME)' (EUROME) targeting Fifth Framework.

assistant: **Abstract**

The research network, EUROME, represents Centers of Excellence in Europe where recent technologies in transcriptome (microarrays) as well as proteome analysis are applied to study with the use of transgenic and congenic animal models human autoimmune diseases primarily rheumatoid arthritis (RA). Susceptibility genes for autoimmune diseases are identified and their functions are determined. Targets for studying novel treatments are evaluated i.e. to stop neoangiogenesis in inflamed tissues. Gene and cell based intervention strategies are investigated to treat autoimmune diseases (rheumatoid arthritis). Common mechanisms that cause autoimmune diseases are determined. EUROM research leads to a genome-base individualized medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tackling socioeconomic inequalities in smoking: learning from natural experiments by time trend analyses and cross-national comparisons' to be submitted under Seventh Framework.

assistant: **Abstract**

For any strategy aimed to reduce socioeconomic inequities in health in Europe it is vital to tackle the large and widening inequalities in smoking. However, there is only limited evidence on effectiveness of tobacco control policies in terms of reducing inequalities. Especially lacking are evaluations of the effects of policies that have actually been implemented in different European countries. In addition, no studies have assessed the role of “strategic drivers” such as social welfare or educational policies.The aim of the proposed project is to analyse various “natural policy experiments” within Europe with the aim to generate new empirical evidence on the effectiveness of possible strategies to reduce inequalities in smoking. The project has three parts. First, time trends in various European countries will be analyzed with the aim to assess whether changes in national tobacco control policies have influenced inequalities in smoking cessation among adults. Second, comparisons between European countries will be made with the aim to assess whether cross-national differences in specific tobacco control policies were associated with inequalities in smoking initiation among adolescents. These cross-national comparisons will also assess whether different types of educational systems are associated with inequalities in smoking initiation. Third, the project will review the published results of intervention studies, and integrate these with our results. The combined evidence base will be disseminated across Europe, especially among those who are involved in the development of tobacco control policies and health-in-all policies.This innovative project will develop comparative research into a new strategy for the evaluation of natural experiments, combining methods from diffe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Clearance Of Microbial Biofilms by Advancing diagnostics and Therapy' (COMBAT) under Horizon 2020.

assistant: **Objectives**

Every year chronic infections in patients due to biofilm formation of pathogenic bacteria are a multi-billion Euro burden to national healthcare systems. Despite improvements in technology and medical services, morbidity and mortality due to chronic infections have remained unchanged over the past decades. The emergence of a chronic infection disease burden calls for the development of modern diagnostics for biofilm resistance profiling and new therapeutic strategies to eradicate biofilm-associated infections. However, many unsuccessful attempts to address this need teach us that alternative perspectives are needed to meet the challenges.The project is committed to develop innovative diagnostics and to strive for therapeutic solutions in patients suffering from biofilm-associated infections. The objective is to apply data-driven science to unlock the potential of microbial genomics. This new approach uses tools of advanced microbiological genomics and machine learning in genome-wide association studies on an existing unprecedentedly large dataset. This dataset has been generated in my group within the last five years and comprises sequence variation and gene expression information of a plethora of clinical Pseudomonas aeruginosa isolates. The wealth of patterns and characteristics of biofilm resistance are invisible at a smaller scale and will be interpreted within context and domain-specific knowledge.The unique combination of basic molecular biology research, technology-driven approaches and data-driven science allows pioneer research dedicated to advance strategies to combat biofilm-associated infections. My approach does not only provide a prediction of biofilm resistance based on the bacteria´s genotype but also holds promise to transform treatment paradigms for th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deep-level modeling of novel germanium-based superconductive quantum devices' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

A great scientific and technical challenges of our time is to engineer a scalable quantum computer, and proximity-induced superconductivity is one of the most important ingredients in many quantum devices. Proximitized III-V semiconductors can host a hard superconducting gap and have been vastly studied in super-semi quantum devices. Nevertheless, these material compounds are not suitable for spin-based qubits due to their large hyperfine interaction and are hence not ideal for use in hybrid devices. One of the most promising, but so far unexplored researched materials to use in such hybrid quantum devices is germanium: it is a potentially ideal host for proximity-induced superconductivity, and exhibits a hard superconducting gap, but can also be used for spin-based qubits since it has suppressed hyperfine interaction and can be isotope purified to be nearly nuclear-spin free. Additionally, it has an exceptionally large hole mobility, strong intrinsic spin-orbit coupling, as well as tunable g-factors, making it an ideal material to use in quantum devices. However, the mechanism for the superconducting proximity effect in germanium is still unknown. In this project I will develop band models based on atomistic orbitals (kp theory), and combine them with T-matrix methods from Greens function theory, to show what mechanisms are responsible for proximity induced superconductivity in the hole bands of germanium. I will apply the results to g-factor dependent Andreev spin qubits and phase- and gate-tunable long-range spin-qubit couplers. I will predict effective spin-orbit coupling and g-factors in these superconducting quantum devices, using effective low-energy models (discretized on a lattice) to predict outcomes of future experiments on germanium-based quantum information
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Accelerated Additive Manufacturing: Digital Discovery of a New Process Generation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Additive Manufacturing (AM) by Laser Powder Bed Fusion (LPBF) has the potential to revolutionize future product development, design and supply chains. Since the underlying multi-scale physics are not well understood, its potential can presently not be exploited. Sub-optimal process conditions lead to severe defects on different scales, rendering parts unsuitable for use. Critically, known regimes of stable processing go along with very low built rates, i.e., very high costs compared to other processes. This limits LPBF to selected high value applications such as medical devices but prohibits applications in mass production where it otherwise could allow for entirely new technologies. ExcelAM aims at the digital discovery of novel high-throughput process regimes in LPBF, to increase build rates by at least one order of magnitude. Computational modeling would be perfectly suited for this purpose since it allows to observe physics that are not accessible to measurement and to study novel process technologies that are not feasible with existing hardware. Unfortunately, existing computational tools are by far not powerful enough, given the complexity of LPBF. Therefore, ExcelAM will develop novel game-changing methodologies, grouped into two main classes: First, novel high-fidelity multi-physics models will be developed, capturing the complex multi-scale nature of LPBF. These are combined with cutting-edge high performance computing schemes, allowing for predictions on unprecedented time spans and system sizes. Second, novel data-based learning approaches will be developed to enrich the physical models with process data, while exploiting the manifold of existing data as effective as possible. Based on these cutting-edge tools, ExcelAM will push the limits of LPBF. Moreover,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigating the link between histone phosphorylation and yeast 14-3-3 proteins in programmed cell death' in the context of a Sixth Framework call.

assistant: **Objectives**

Post-translational modifications of histones including acetylation and methylation, serve as signals for various cellular processes, such as, transcription, DNA repair, and cell signalling. Histone phosphorylation has recently been connected to programmed cell death, also known as apoptosis, in both mammals and yeast.Specifically, phosphorylation of serine 10 within histone H2B in the yeast S. cerevisiae has been linked to chromatin compaction during the late stages of apoptosis. Phosphorylation of this am ino acid residue is catalyzed by the yeast kinase Ste20. However, it still remains unknown how the activity of Ste20 towards H2B is controlled.Interestingly, Ste20 has been shown to interact with the yeast 14-3-3 proteins, bmh1 and bmh2, which play a role in the regulation of histone phosphorylation. Based on these findings and the fact that mammalian 14-3-3 proteins are implicated in the apoptotic process, we hypothesize that the bmh proteins are involved in cell death by associating with phosphorylated histones.The experiments outlined in this proposal are aimed to determine; 1) whether the bmh proteins have an apoptotic function in yeast, 2) whether the bmh proteins regulate the activity of Ste20, 3) whether the bmh proteins bind specifically to phosphorylated H2B-Ser10, and 4) whether induction of apoptosis affects the localization of bmh proteins.These experiments should provide a better knowledge of the molecular mechanisms that underlie the apoptotic process. It is critical to understand these mechanisms because a defect in the apoptotic pathway can often lead to human proliferative diseases such as cancer.Additionally, these studies will provide me with the opportunity to explore and learn to use yeast as an experimental model system. Most importantly, I will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Types for Communicating Software Systems' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

This research directly addresses the need for software technology to develop reliable and robust communicating computer systems. It directly responds to the FP6 objective on Communication, computing and software technologies (Council decision 2002/834/EC) to improve the performance, reliability, cost-efficiency, functionality and adaptive capabilities of communications and computing technologies so as to meet the growing needs of application. We shall combine skills and experience from two long-standing research teams, the Coq (proof assistant) team in France and the Epigram (programming language) team in Britain. Coq and Epigram share a broadly compatible basis but have developed in distinct directions with complementary strengths.We must share our understanding to face the challenges ahead, hence we seek two years' funding for Nicolas Oury, an outstanding young researcher from the Coq team in Paris (Orsay), to do post-doctoral research with the Epigram team in Nottingham, studying the construction of reliable communicating software systems. Oury's doctoral research is crucial for the success of this project, as it lays an essential and previously missing piece of the theoretical foundations for reasoning about communicating processes. Joining the group in Nottingham will be extremely beneficial for Oury's future research career due to the complementarity of the approaches of the French and British groups and the strength of the Nottingham team in working on applications of Type Theory in Programming.Our objective is to develop programming language and tool support geared towards productivity and reliability of communicating software systems. Our approach is to extend the existing Epigram platform, which already provides language and tool support for reliable algorithm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'EXPERIENCE NATURAL FREEDOM OF MOVEMENT IN VR WITH THE OMNIDECK – THE ULTIMATE VR EXPERIENCE'.

assistant: **Concept**

MSE Omnifinity AB is a company specialized in the development of hardware for Virtual Reality. The company developed a 360-degree VR locomotion device which allows users to physically move within a simulated world. The Omnideck can be used in various industries to improve analysis, enhance design processes, for exploration or training.  In 2018, the company completed a beta-test with 40 external users (TRL=6). The key objective of this project is to assess the technical feasibility and the commercial potential of the Omnideck. The company intends commercialize the product in three targeted market segments, namely, innovation & research, entertainment and defense & security. In all three segments, the company collaborates with partners: R&D labs, architectural visualization studios, construction companies as well as safety and defense firms. In 2013, Omnifinity obtained an R&D grant obtained from Vinnova, Sweden’s innovation agency.