RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Advancing in the comprehension of the pathogenical mechanisms of priondiseases. Spleen and brain delivery of antiscrapie compounds by chitosan nanoparticles'.

assistant: **Innovation**

Research objectives and content Taking into account that the two relevant organs involved in the replication of the TSE agents (or priors) and accumulation of PrPsc (prion protein scrapie) are the spleen and the brain, we have conceived two approaches, based on the use of nanoparticles of chitosan as drug delivery systems, for contributing to the comprehension of the prion diseases:- the first aim consists in the evaluation of the effects induced by the selective targeting to the spleen of compounds which are supposed to inhibit the accumulation of the PrPsc:- Inhibition of PrP synthesis by an antisense oligonucleotide strategy. - Inhibition of Prpsc accumulation (transconformation?) by polyene antibiotics. - Destruction of target cells supporting PrPsc accumulation in spleen with clodronate.- the second one is to investigate in vivo the role of the microglial cells in the pathogenesis of TSEs. These cells have been proven to be indispensable for neuronal toxicity of PrPsC in vitro and a strategy of depletion will be used in vivo. The working system will be to engraft murine embryonic nervous system hyperexpressing PrP in the brain of mice lacking PrP. The graft tissue will be depleted in vitro for microglial cells with LLME (L-leucin methyl ester) or clodronate before grafting. The microglial depletion will then be maintained in vivo by the delivery of the same molecules with drug carrier systems.This research proposal could also open new perspectives for the pharmacological treatment of scrapie in experimental models. Training content (objective, benefit and expected impact) The use of targeted nanoparticulate formulations able to deliver anti-PrP oligonucleotides and other anti-PrP compounds to the brain and to the spleen may allow to highlight some crucial aspects o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Innovative anti-influenza drugs excluding viral escape' (ANTIFLU), addressing dissemination and exploitation.

assistant: **Impact**

ANTIFLU is to develop innovative drugs against influenza virus infections based on a novelconcept that precludes the development of viral resistance and ensures efficacy againstupcoming pandemic influenza strains. Viral replication is known to depend on multiple hostfactors. Whilst traditional anti-influenza treatments usually target viral factors, ANTIFLU willaim at drugs interfering with host-response pathways. The concept of drugs targeting humanfactors, established in treatment of other diseases, has yet not been sufficiently explored fortreatment of viral infections, although it bears compelling advantages over conventionalantiviral therapies: (i) the avoidance of viral escape mutants and (ii) the broad coverageagainst unprecedented viral variants.ANTIFLU aims to fully exploit this potent approach to fill critical gaps in our current treatmentand prevention options against seasonal and pandemic influenza virus infections. By buildingupon an existing panel of potent human targets and firm knowledge derived from FP6 projectRIGHT, an interdisciplinary consortium will pursue the identification and validation of smallmolecule ligands and inhibitory RNA molecules effective against influenza infection.Promising modulators will form the basis to generate lead molecules that will be furtherrefined to yield clinically applicable therapeutics. Initial preclinical studies will aim at providingproof of concept in animal models, safety and toxicology profiles. They will allow initiatingcomplete clinical trials immediately after the phase of FP7 support, thanks to the commitmentalready taken by investors from the private sector. The consortium includes several SMEs,internationally renowned research groups and clinical institutions with extensive experiencein anti-influenza treatm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The European first generation of aquaculture SERS-based Biosensor' in the context of a Horizon 2020 call.

assistant: **Objectives**

Aquaculture industry has turned essential to fulfil the growing demand of fish & shellfish seafood. With latest global production peaked at 171 M tones in 2016, aquaculture represented 47% of the total and a first sale value of $232 billion. Nonetheless, in spite of its importance, yet the early detection and monitoring of infectious disease agents during the whole process is not sensitive neither fast enough. Consequently, aquaculture industry faces up to $6 billion per year of productivity losses due to uncontrollable diseases, because they are not identified on time.In response, we have developed the first equipment for the detection of infection diseases within minutes in aquaculture. Our solution uses antibody-gold nanoparticles that specifically capture the infection disease agents present in water sample. Once combined, the agent-antibody-nanoparticles cross a microfluid chamber that after been irradiating gives an amplified light signal if the agent is present. This signal is immediately detected by surface-enhanced RAMAN spectroscopy (SERS). Thanks to the sensitivity of the SERS-technology, our equipment enables a fast treatment respond within 30 min for three of the main infections in Europe affecting salmon, abalone and flatfish. Thus, thanks to AQUASERS equipment we will reduce the productivity losses for salmon, abalone & flatfishs in Europe and Worldwide. Furthermore, after 4-year sales, our product will give net revenues of ~€66.84M, net profits of ~€46.64M and considering the investment of €2.69M, a ROI of ~17.33 euro per € invested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'FAIR FOOD AND TRADE SYSTEMS FOR AFRICA THROUGH FOOD CONVERGENCE INNOVATION'.

assistant: **Concept**

The FCI4Africa project champions a holistic approach to African agriculture, promoting fair, sustainable, climate-neutral, and health-promoting trading practices while ensuring economic prosperity at all levels and respecting human rights. It bridges the gap between technical compliance and social justice by empowering smallholder farmers and small and medium-sized enterprises, facilitating trade compliance through a digital platform, and enhancing food safety. By evaluating the impact of certification criteria like deforestation-free, organic, and fair trade, and guiding policymakers, FCI4Africa fosters a just transition for African farmers, processors, and traders, expanding their intra-African, and EU trading opportunities. Leveraging past projects and cutting-edge technologies, FCI4Africa connects stakeholders across diverse regions and jurisdictions, paving the way for a more sustainable and equitable African agricultural sector.


**Keywords:** Food Trade, Africa, Fairness, Justness, Sustainability, Food Convergence Innovation, Use Cases
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Peopling Europe: How data make a people' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Who are the people of Europe? This question is facing statisticians as they grapple with standardising national census methods so that their numbers can be assembled into a European population. Yet, by so doing—intentionally or otherwise—they also contribute to the making of a European people. This, at least, is the central thesis of ARITHMUS. While typically framed as a methodological or statistical problem, the project approaches this as a practical and political problem of assembling multiple national populations into a European population and people.Why is this both an urgent political and practical problem? Politically, Europe is said to be unable to address itself to a constituted polity and people, which is crucial to European integration. Practically, its efforts to constitute a European population are also being challenged by digital technologies, which are being used to diversify census methods and bringing into question the comparability of national population data. Consequently, over the next several years Eurostat and national statistical institutes are negotiating regulations for the 2020 census round towards ensuring 'Europe-wide comparability.'ARITHMUS will follow this process and investigate the practices of statisticians as they juggle scientific independence, national autonomy and EU comparability to innovate census methods. It will then connect this practical work to political questions of the making and governing of a European people and polity. It will do so by going beyond state-of-the art scholarship on methods, politics and science and technology studies. Five case studies involving discourse analysis and ethnographic methods will investigate the situated practices of EU and national statisticians as they remake census methods, arguably the most
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Elucidating structures and functions in the arachnoid barrier'.

assistant: **Innovation**

Less is known about the structural and functional importance of the arachnoid barrier than any other CNS barrier, including the blood-brain barrier. Animal models of arachnoid barrier impairment are not known/have not been analyzed. The sophisticated architecture and cellular specialization of the arachnoid barrier includes tight- and tricellular junctions joining two cell layers, direct contact with other arachnoid cells, and the specific expression of a broad repertoire of influx and efflux transporters, suggest major importance. Lack of understanding of the arachnoid barrier represents a conspicuous knowledge void in neurobiology. The Arrachnobarrier2.0 project seeks to elucidate and understand these features and to examine their pathophysiological importance. We will test the hypothesis that arachnoid barrier disruption may have serious consequences for CNS function. We will also test the hypothesis that the arachnoid barrier is responsive to diverse disease conditions and can contribute to disease pathophysiology. We hypothesize that the arachnoid barrier has regional cellular and molecular adaptations that underlie CSF transit from the subarachnoid space to dural lymphatics. Some of these sites are known, such as olfactory nerve and cranial nerve exit sites, whereas others are more speculative, such as arachnoid granulations and sites of bridging vein crossing. The three Specific Aims in this proposal will address these aspects of arachnoid barrier structure, function, molecular and regional heterogeneity, and pathophysiology. This proposal is innovative and has potential for ground-breaking discovery because arachnoid structure and function has remained elusive since its anatomic description ≈500 years ago and the discovery of its barrier properties ≈50 years ago
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Adding high value to wasted raw material from pulping industry'.

assistant: **Objectives**

Ecohelix has developed a technology which transforms widely available, sustainable, pulp industry waste into high-performance polymers. Membrane filtration and biotechnology are applied, using proven large-scale processing techniques, to isolate and modify wood biorefinery derived hemicellulose and low molecular weight lignin. The technology has been verified both for production and as an end product (to TRL6).The end product can replace petroleum-based products such as PVOH, PVAc and SDS and foodcrop based products with a highly sustainable, biodegradable, high performance product which reduces CO2 emissions and adds value to the pulp industry. Ecohelix can tap into a large and stable availability of raw material that pulping processes create - and at the same time offerprocessing benefits for the mills.A wide range of potential applications have been identified in the cosmetics, pulp and paper chemicals, packaging and construction industries. For certain applications, including as an emulsifier for paper board sizing chemicals and in cosmetics, tests demonstrate a significantly superior performance. The performance as an emulsifier for paper sizing chemicals (the paper sizing process provides water resistance and strength for applications including liquid packaging board) is x10 better than the existing market solutions.Ecohelix’s value chain involves close partnerships with both pulp mills and speciality chemicals producers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spatial and temporal study of electron and x-ray emission in the compressed zone producted by collision of low z tj-hin foils; influence of laser beam conditions' (1994-1998).

assistant: **Innovation**

The project is concerned with atomic physics properties and with the macroscopic behaviour of hot and dense plasmas produced by the collision of two foils accelerated by laser beams. The transient ionic molecules formed in these highly correlated and highly ionised environments have their own specific spectral signatures on the line profiles. These signatures can be exhibited only if the collision is sufficiently planar and if the plasmas properties include it being dense and emissive. Laser-matter interaction experiments will be carried out in order to analyse the effects of the spatial and temporal laser beam profiles on the emitted spectra: producing flat top focal spots will give rise to higher plasma densities with improved planar quality, resulting in better spectral and spatial accuracies. These experiments will be driven by numerical simulation; the spectra will be interpreted by means of spectral profile codes accounting for monocenter ions and transient molecules emission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Joint Communication and Sensing in 6G Networks'.

assistant: **Objectives**

Having lost a significant share of the market to big players from the US and Asia, Europe is no longer at the forefront of thetelecommunication industry. However, new services focusing on remote health monitoring, industry 4.0, and autonomous vehicleshave created a unique opportunity for Europe to regain a leading position in 6G. Unlike traditional mobile broadband that mainlyconnect people, these emerging services not only exchange data but also critically rely on accurate information from theirsurroundings (i.e., sensing). Consequently, joint communication and sensing (JCAS) is a key feature of 6G networks, where devices willembed wireless sensing capabilities (e.g., localisation, activity recognition). JCAS faces major challenges since it demandsfundamental changes to current communication systems. 6thSense follows a holistic approach to address these challenges by: (WP1)Going beyond traditional sub-6GHz systems and enabling sensing in new B5G/6G communication bands, i.e., millimetre-wave andvisible light; (WP2) Addressing distributed sensing and networking challenges through architecture and protocol design; (WP3)Handling the analytical complexity of JCAS by combining the strengths of classical signal processing and optimisation models withadvanced machine learning techniques; (WP4) Transferring these research contributions to industry-relevant applications inhealthcare, manufacturing, and automotive sectors. 6thSense is an intersectoral and interdisciplinary cluster of excellence formed byelectrical engineers and computer scientists that has pooled leading members of large EU initiatives (5G PPP), industry leaders (e.g.,Nokia, Ford, Bosch) and academic institutions (e.g., KUL, TUDelft, Princeton, UCLA). Benefitting from this consortium, a comprehensivesoft-skill tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Governing Urban Diversity: Creating Social Cohesion, Social Mobility and Economic Performance in Today's Hyper-diversified Cities' to be submitted under Seventh Framework.

assistant: **Abstract**

The central hypothesis of this project is that socio-economic, socio-demographic, ethnic and cultural diversity can positively affect social cohesion, economic performance and social mobility of individuals and groups. A better social cohesion, higher economic performance and increased chances for social mobility will make European cities more liveable and more competitive. In this period of long-term economic downturn (or sometimes even crisis) and increasing competition from countries elsewhere in the world (e.g. China, India), it is important to find out how and under which circumstances European's urban diversity can be turned into social and economic advantages.Many current urban policies lack a positive view on urban diversity, because they generally focus on the negative aspects of diversity, such as intolerance, racism, discrimination and insecurity. New policies, instruments and governance arrangements are needed, and sometimes they already exist. We have to find out how they have become successful and how they can be implemented elsewhere. When we acknowledge the hyper-diversity of our urban societies, we also have to acknowledge that these societies cannot flourish from standard or general approaches aiming at, for example, economic growth or better housing or more liveable neighbourhoods. Increasingly, more diverse, more tailored arrangements are needed, arrangements that have an eye for hyper-diverse cities and communities.As a result of the project, new and innovative policy instruments and governance arrangements will be suggested that (a) recognise urban diversity as a positive aspect; (b) increase interaction and communication between the diversity of groups in urban society; and (c) increase participation to satisfy the needs of the communities.The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ultra-Stable Molecular Force Spectroscopy with Micromachined Transducers' (UTMOST).

assistant: **Innovation**

The objective of the proposed research is to develop micromachined transducers for improved atomic force microscopy (AFM) based biomolecular mechanics measurements. The research focus will be on the design and microfabrication of these transducers that allow ultra-stable measurements for applications in life sciences. A major research effort will be on performing long-time scale biological experiments using these transducers. Successful implementation of ultra-stable molecular force spectroscopy with micromachined transducers (UTMOST) will facilitate biomolecular measurements with unprecedented stability and accuracy. The proposed approach is to design transducers that thermo-mechanically match the AFM cantilevers. The transducer comprises a micro-stage anchored to its substrate using bimaterial and isolation legs. Bimaterial legs are made of two different materials with different values of coefficient of thermal expansion (CTE). Due to CTE mismatch, these legs deflect under thermal fluctuations. It is guaranteed by design that the micro-stage deflects identically with the AFM cantilever. This provides constant tip-to-transducer distance at all times so that the force applied on the biomolecules stays the same. Originality of the proposed research is to utilize microsystems technology as an integral component of a novel AFM-based assay for biomolecular applications. As such, novel concepts and methods introduced with UTMOST will advance both engineering and life sciences. Positioned between microsystems technology and single-molecular studies, the proposed research will contribute to European technological and scientific excellence. This proposal describes the methodology for the development of UTMOST devices in depth. The details of the biomolecular experiments planned