RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Developing and validating a growth model for short rotation poplar that accounts for genetic variability' (1998-2002) under Fifth Framework.

assistant: **Objectives**

TRAINING CONTENT will include:(a) formal courses in appropriate computer programming languages;(b) collaborative research with an inter-disciplinary team carrying out research on aspects of growth and yield of fast-growing short rotation coppice species for renewable bio energy;(c) collaborative opportunities with scientists involved in joint projects lead by the host organisation. ANTICIPATED IMPACT. The absence of model sensitivity to growth variability resulting from the interactions between the genetic make-up of a plant, its environment and the age of the individual is a recognised limitation of the current generation of models. Through his research the applicant will have the potential to become a major player in the development of new tree growth models. Products of the research will benefit the host organisation, in its capacity as a leading provider of scientific products used by policy makers, industrial organisations and scientists in forestry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Non perturbative and formal aspects of quantum field theories' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objective of the project is an increase of the understanding of som non perturbative aspects of quantum field theories such as instanton effects, renormalons and the possibility of its reconstruction by use of resummation techniques.  The possibility of the observation of instanton mediated chirality changing processes is strongly suggested by the theoretical results obtained in the analog problem of electroweak instanton induced fermion number violation (to which I devoted some work), together with the largeness of the strong coupling at small scales.  The physical comprehension of the renormalons effects (in particular of IR renormalons) is an urgent problem that recently have been treated by many interesting pioneering works that we think should be pursued on.  The lack of Borel summability of Q.C.D. and of many others quantum fiel theories motivates the research of new resummation techniques. The Delta Expansion - Order Dependent Mapping is one such technique that gives convergent approximations and allow to treat some quantum cases otherwise non Borel summable: we retain that the possibility of its extension (in particular to four dimensional field theories) is worth studing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scouting for new scientific talents and growth of new research projects through public involvement in research and development and demonstration of common European scientific roots' under Sixth Framework.

assistant: **Concept**

This project builds on four years long experience with similar projects with strong national and regional and international impact. The goals of the proposal are: (a) to scout for new talents for research and promote their enthusiasm through direct involv ement in research projects on an research institution, (b) to improve public understanding of research by exhibition of results in newly built technology object combining renewable energy and biotechnology and (c) contribution to overall attrractiveness of European Research Area by involvement of students and researchers from outside European Union (USA, Eastern Europe). These goals will be addressed by two major activities, (a) summerschools and student clubs and (b) exhibition and multimedia show for gene ral public and several smaller activities such as media promotion in media, on-line internet data transfer, presentations to secondary school teachers etc. The project will utilise the infrastructure of the Academic and University Center in Nove Hrady, the research institution with excellent record in basic and applied research located on the border between Austria and Czech Republic.The project infrastructure enables combination of scientific work, technology transfer, education, free-time activities and accomodation in one place thus enabling high impact focused promotional activities for a given period of time. The actors are one university institute (faculty level), one institute of the Academy of Science of the Czech Republic and one civil association working in synergy and utilising the best possibilities within their infrastructure and legal status. Data for content of the project will be provided also by partners involved in European research arena. International impact will be achived through collab orating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The physiology and genetics of fruit formation: from genes to networks' to be submitted under Seventh Framework.

assistant: **Abstract**

The fruit is the result of the development of the ovary and it is a major evolutionary acquisition of flowering plants. Fruits likely evolved to protect the developing seeds and to ensure seed dispersal adopting an incredible array of morphologies and inventing many types of mechanisms for seed dispersal. Dry dehiscent fruits mechanically disperse the seeds, while fleshy fruits develop tasty tissues that induce fauna to eat them and therefore act as the dispersal agent. Dry dehiscent fruits (those that dry and open at maturity to release the seeds), correspond to the ancestral type of fruit (Knapp, 2002), however the fruit of the model specie Arabidopsis thaliana, the silique, with its specialized dehiscence zone, is a more recent evolutionary conquer.The overarching objective of this proposal ”The physiology and genetics of fruit formation: from genes to networks” (FRUIT-look), aims to strengthen research partnerships through short period staff exchanges and networking activities between European research organisations and American organisations. The research topic of this exchange programme concerns fruit formation.FRUIT LOOK aims to address the following key questions:Which are the genetic and molecular networks regulating fruit formation and morphology?Do plant hormones act as morphogens during fruit development?Can we elaborate a model able to explain fruit forms?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Feasibility study of a new tool for managing, processing, sharing and transferring huge amounts of scientific data  (DataNimbus)' under Horizon 2020.

assistant: **Concept**

We are currently living in the Big Data era in which different technologies produce thousands of terabytes of data every minute. Real value of this data remains on the information that can be extracted and understood from it, not only on its creation. As data is generated so fast, we need to be able to transfer, process and analyse it, so we can understand it as fast as it is generated. This is a key concept for Bioinformatics, which aims to make personalized medicine a real thing. In this field, Big Data from omics Sciences (Genomics, Transcriptomics, Proteomics and Metabolomics) is usually processed far from the place of generation and files are transferred using FTP or moved using hard disks. We will develop DataNimbus, a commercial solution to transfer, store, share and analyse this bioinformatic data from a single product. Existing solutions are not able to cover all of these needs. DataNimbus aims to bring closer usually expensive and unaffordable data movement and processing technologies to European SME and research facilities.This solution will be cloud based, offered on a pay-per-use basis. Cloud computing usage implies some economic and environmental advantages, and also provides some other strong benefits like resiliency and redundancy, go faster on the projects deployment, scale as needed and lower maintenance costs. Finally, cloud approach will allow us to build our infrastructure with its real needs. The proposed work, objectives, will be summarized on a detailed business plan and a feasibility study. To reach it, a market study will be done, allowing us to locate main potential customers, make agreements or contacts with partners and hardware providers and validate our commercialization strategy and market segmentation. It will be also supported with the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Doing Charges Right: Modelling Ion-Controlled Biological Processes with the Correct Toolbox', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Electrical stimuli are essential for a plethora of biological functions. Unlike in electronics, where electrons form currents, nature rather exploits ions as charge carriers. Lack of a consistent molecular picture of action of ions impairs progress in fundamental understanding of ion-controlled biological processes and in designing smart strategies for fixing ion-related pathological conditions. Molecular simulations represent a powerful tool for modelling such processes, however, they can only be as good as is the underlying interaction model (force field). A major drawback of commonly used force fields is the lack of description of electronic polarization, which results in severe artifacts such as a dramatic over-binding of ions, preventing, e.g., accurate modelling of calcium signalling processes. This now well-recognized deficiency hampers faithful modelling of complex ion-involving biological processes.We will employ machine learning techniques to build a de novo comprehensive force field for biological systems, that accounts for electronic polarization in a mean field way via charge scaling. This approach will qualitatively improve modelling of ions in biological contexts without additional computational costs. This will allow us to address accurately the following highly relevant ion-specific processes of increasing complexity from molecular over cellular to organ levels:1. Dissolution of radical anions of aromatic molecules as key intermediates in technologically and biologically important non-enzymatic and enzymatic Birch reduction processes.2. Direct membrane translocation of cationic cell penetrating peptides with a potential of drug delivery. 3. Circulation of calcium ions as signalling charge carriers through ion channels of hair cells in the cochlea.At the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolution of gene regulatory networks by means of natural selection and genetic drift', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Evolution is a process that largely occurs within populations.  Contrary to common belief, the evolution of complex genome architecture is not driven by natural selection alone. In small populations, genetic drift overwhelms weak selective forces, yielding populations that evolve “in principle” neutrally. Non-adaptive stochastic forces such as mutation, recombination, and genetic drift, also influence genetic material composition under neutrality. On the other hand, selection optimizes expression levels by operating on sequence polymorphisms at gene regulatory regions. Slightly deleterious mutations on the regulatory regions of genes, that affect the binding of transcription factors may increase in frequency by chance alone. Other non-adaptive processes such as gene duplications can change the distribution of the links on each node (gene) of the network.Here, I propose to study the evolution of gene regulatory networks in the population level, by means of genetic drift and natural selection. I will focus on the effects of mutation, recombination, genetic drift and various forms of natural selection (e.g. stabilizing and positive selection) on the polymorphism patterns of the promoter regions. The goal is to identify polymorphism patterns that are created exclusively by natural selection and not by non-adaptive processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Monitoring, Optimisation and Control of Liquid Composite Moulding Processes (COMPROME)' (COMPROME).

assistant: **Concept**

The main limitation of the currently existing Liquid Composite Moulding manufacturing technologies in the fabrication of high quality, affordable and integrated aerospace structures lies in their inability to combine the available information (accurate simulations, measurements, experience and knowledge) that deals with the integrated process (resin flow and cure) into a global controlsystem. To circumvent this limitation, the COMPRÓME project proposes not just the refinement and integration of existing control approaches, but the development of a revolutionary control system applicable to a wide range of LCM processes. It uses the dielectric signal for sensing resin flow and cure processes and consists of:>an integrated, durable and tool-mounted dielectric sensor; >modular monitoring system with embedded knowledge;>a process control strategy;>a global integrated process control (IPC) system;>the manufacturing aerospace components with cost-effectiveness and improved quality The proposed novel global IPC scheme brings full benefit from the use of monitoring devices and the utilisation of the existing process knowledge. The benefits to aerospace manufacturers include the manufacturing cost-effectiveness, while the global nature of the control scheme allows the fabrication of large and complex components (free of joints and bonds), thus contributing to increased safety and weight saving in the aircraft. The system promotes closed mould processing techniques, which possess significant environmental benefits due to reduced emissions in the production area.The main innovations reside in:(a) an integrated, durable and tool-mounted dielectric sensor clusters(b) the multi-sensor. Real-time monitoring system;(c) the interface between composites process simulation tools, process
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Social Inequalities in Bereavement: From Demographic Rates to Lived Experience'.

assistant: **Concept**

Due to the rise in human longevity, many individuals in low-mortality countries can now expect to grow old, to be survived by their children, and to know their grandchildren. Yet, these prospects are not equally shared. Social inequalities in mortality persist and may lead to inequalities in family bereavement. How exposure to bereavement is internalized by individuals and shapes their lives is a key sociological question, with the potential to establish a new research program at the intersection of social stratification, mortality, and kinship demography.Few studies have examined the impact of mortality inequalities from the perspective of the bereaved. Thus, little is known about (1) how demographic factors shape exposure to family bereavement across the life course; (2) how the burden of bereavement varies across social groups; (3) whether inequalities in bereavement give rise to different modes of feeling, thinking, and acting.This study aims to fill this gap by developing a demographic framework of bereavement. First, drawing on life course theory, it conceptualizes the burden of bereavement with respect to intensity (repeated exposure to kin deaths), timing during the life course, and anticipation of the loss. Second, drawing on kinship demography, it recognizes that family bereavement is shaped by variation in kin structure, in addition to differences in kin mortality. Third, motivated by theories of macro-micro relations, it links demographic rates to subjective expectations, wellbeing, and behaviors.The framework will be applied to and compared across Sweden and Israel. Using complete population microdata to trace multi-generational kin networks, the study will estimate the burden of bereavement by age, across cohorts. It will estimate socioeconomic and ethnic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Novel premium pre-filled syringe plunger made by micro- /injection moulding for innovative drug delivery systems and auto injectors'.

assistant: **Concept**

The global pre-filled syringes (PFS) market has currently a volume of more than 4 billion USD and is growing with a CAGR of 10% due to the increase of chronic diseases, growing demand of biologics and biosimilars and a high penetration rate of autoinjection devices. The segment of autoinjectors grows even faster with a CAGR of 24%. But there are challenges, that cannot be fully solved by the current generation of rubber syringe plungers. Biologics are very sensitive to any leachables, that can be extracted from the syringe components. Self-injection devices need an excellent gliding behaviour of the plunger to minimise patients pain-experience during the injection.The innovative miPLUNGER can solve these challenges by introducing a cost-efficient two component TPE/PFA plunger element, that is manufactured in a reliable two-step micro injection moulding process. The new material is inherently free of any harmful leachables and provides excellent gliding behaviour. The process allows a cost-efficient sterile production under cleanroom conditions in just two process steps and a high flexibility in the plunger design.MDX’ customers are the PFS manufacturers, the primary users of miPLUNGER will be producers of sensitive high-value drugs and those of advanced self-injection devices. MDX will cooperate with them early in their drug and device development to create a growing market for miPLUNGER. By making and selling its new plungers to the PFS producers, MDX anticipates a turnover of 9.6 million €, and an total staff headcount of 28 employees in 2024.In the feasibility study, a detailed analysis of the best-fitting market segments will be conducted, including the cooperation with pilot customers for the validation of the business idea, as well as the elaboration of a thorough
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Age-dependent Regulation of Dendritic Cell Development and Function' (2014-2020).

assistant: **Concept**

Early life immune balance is essential for survival and establishment of healthy immunity in later life. We aim to define how age-dependent regulation of dendritic cell (DC) development contributes to this crucial immune balance. DCs are versatile controllers of immunity that in neonates are qualitatively distinct from adults. Why such age-dependent differences exist is unclear but newborn DCs are considered underdeveloped and functionally immature. Using ontogenetic tracing of conventional DC precursors, I have found a previously unappreciated developmental heterogeneity of DCs that is particularly prominent in young mice. Preliminary data indicate that distinct waves of DC poiesis contribute to the functional differences between neonatal and adult DCs. I hypothesize that the neonatal DC compartment is not immature but rather that DC poiesis is developmentally regulated to create essential age-dependent immune balance. Further, I have identified a unique situation in early life to address a fundamental biological question, namely to what extent cellular function is pre-programmed by developmental origin (nature) versus environmental factors (nurture).In this proposal, we will first use novel models to fate map the origin of the DC compartment with age. We will then define to what extent cellular origin determines age-dependent functions of DCs in immunity. Using innovative comparative gene expression profiling and integrative epigenomic analysis the cell intrinsic mechanisms regulating the age-dependent functions of DCs will be characterized. Because environmental factors in utero and after birth critically influence immune balance, we will finally define the impact of maternal infection and metabolic disease, as well as early microbial encounter on DC poiesis. Charact