RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'QuantERA II ERA-NET Cofund in Quantum Technologies'.

assistant: **Concept**

Quantum Technologies (QT) is a highly interdisciplinary, paradigm-changing area of research. European researchers have been at the forefront of these developments, delivering many groundbreaking scientific results and advancing technological exploitation. For the past four years, the QuantERA network has been successfully providing the research community with a coordinated Europe-wide approach to support cutting-edge research in QT. Building on this experience, with EU support, the QuantERA consortium (currently present in 30 countries) will continue its activities and develop them even further. The central objective of this proposal is to launch a transnational co-funded call with a planned budget of over €26M of national contributions. €15M of EU contribution is expected to support the co-funded call budget and project tasks. In accordance with the FET Work Programme 2018-2020, the scientific scope of the QuantERA II co-funded call will complement the Quantum Technologies Flagship activities. QuantERA II will seek to effectively liaise with the QT Flagship and other stakeholders in the field of QT research to make the best use of the collective European experience in QT research funding, as well as address the gender imbalance in QT research and spread the research excellence across European Research Area (ERA). A range of additional activities will be integrated into the launch of the co-funded call: strengthening the multilateral dialogue with policy makers regarding the design of future funding instruments, stimulation of networking and exchange of best practices, continuation of mapping of public QT policies in Europe, use of the Guidelines on Responsible Research and Innovation in QT developed in the first QuantERA programme. The QuantERA II proposal conforms to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ensuring Assessment of Safety Innovations for SMR' (EASI-SMR).

assistant: **Concept**

The EASI-SMR project intends to address the safety issues related to the LW-SMR in order to provide advances that should support implementation of such technologies as soon as possible. The EASI SMR project activities are aimed at ensuring that these reactors will be designed, constructed, commissioned and operated in the safest possible way and in accordance with existing regulations. The consortium was carefully chosen so that the research entities can provide the necessary research teams and support facilities across the European Continent and beyond.EASI-SMR will address the safety issues associated with major LW-SMR innovations:•Passive systems•Soluble Boron-free cores•Co-generation and hybridation•Additive manufacturing to improve compactness of Nuclear Steam Supply System•Multi-units operationThe work aims to provide insights for European LW-SMR projects, in particular:•NUWARD SMR, a French design of a reactor generating 170 MW of electricity production.•LDR-50, a Finnish design of a district heating reactor of 50 MWEASI-SMR is closely linked with NUGENIA TA6 and the European SMR pre-Partnership’s WS5.


**Keywords:** SMR, Passive safety system, streamlined licensing, code-validation, reliability assessment, nuclear physics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Forensic Intelligence and Remote Sensing Technologies for nature conservation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Biodiversity is under severe pressure due to a myriad of problems, including but not limited to habitat fragmentation, overexploitation, climate change, pollution, invasive species and hunting. Changes in land and sea use can lead to conflict situations with production animals and/or human communities (human-wildlife conflict). The exploitation of natural resources brings with it illegal activities: poaching of species of flora and fauna that have a high value on the (black) market, trading of rare and exotic animals and plants and setting fire to forestry and nature areas to force land-use designation changes to agriculture or commercial uses. To ensure that ecosystems are healthy, resilient to climate change and rich in biodiversity to keep delivering the essential range of services, we need better understanding of why and where biodiversity is declining and what the key triggers are. We propose a model-driven and continuous form of ecosystem monitoring. By assessing not only numbers of species and state, but also the modelled ecological and anthropogenic processes within an ecosystem, we are able to find cause-effect relations and improve our monitoring models based on retrofits and simulations to understand changes even better. The models (Digital Twins), are thus a means for learning and the creation of context to translate environmental observations into facts and actionable information (intelligence) for site managers and policy makers. As almost all pressures on biodiversity are man-induced, we combine the domains of ecology and forensic science. This novel approach gives us access to robust scientific methods to detect and recognise (traces of) human (illegal) activities that negatively affect the environment. We will make use of remote sensing & data science (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Improvements in Tyre Casing Assessment and Consequent Retreadability'.

assistant: **Objectives**

The aim of the proposed research is better assessment of new tyre casing integrity in order to increase the number of tyres in Europe that are recycled by retreading. At present, it is difficult to determine the quality of a casing for retreading. A number of non-destructive test procedures are employed which detect casing faults such as ply separations and broken cords, but they do not yield information on the overall state of the casing. There is an urgent need by SME Retreaders for improved assessment methods for used tyres and also a better understanding of the quality" of new tyres as they become the basic 'raw material' of the retread industry. The main research tasks are: (i) casing evaluation studies to establish a best practice laboratory test methodology. (ii) development of a prototype novel retreadability test machine. (iii) establish and maintain a database on the retreadability of different tyre makes. A successful outcome will benefit manufacturers of retreaded tyres and other sectors concerned with transport, safety, recycling and the environment. It will help the EU objective of retreading more vehicle tyres. It will supply substantive information on the retreadability of new tyres which will allow retreaders to more readily foresee casing faults, save costs and improve safety. The estimated European market for retreaded tyres approaches 2BECU and involves retreading some 20% of all tyres. The EU goal is to increase retreading towards 30 % by the year 2000. This project will contribute towards achieving that goal."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of rationally designed enzyme kits' in the context of a Horizon Europe call.

assistant: **Objectives**

Enzymes exhibit high efficiency, specificity, selectivity, biodegradability, non-toxicity, and the ability to function effectively under gentle biological conditions. These qualities render enzymes a sustainable and eco-friendly substitute for traditional catalysts within industrial settings. However, harnessing enzymes for industrial applications often necessitates extensive and costly experimental engineering efforts. Computational methods hold promise as potential solutions, but these have not yet demonstrated the ability to rapidly design highly efficient enzymes that mimic those found in Nature. As opposed to other methods, our computational approach developed in the previous ERC-STG can introduce active site and distal mutations that modulate the enzyme conformational dynamics, achieving increases in catalytic efficiency of up to 1000-fold. This project aims to exploit the proprietary technology developed in ERC-STG and ERC-POC for generating a set of patentable rationally designed enzyme kits focused on stereoselective carbon-carbon bond formation. KITZYME aims to create a spin-off for the exploitation of the new set of rationally designed enzyme kits as well as the proprietary technology developed for enzyme optimization. Both the enzyme kits and our technology are the cornerstone of the project, and will provide industries with a cost-effective, scalable, and environmentally sustainable solution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Driving innovation from universities into scientific enterprises' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

DIFUSE aims to develop a model for close (integrated) trans-national cooperation between university knowledge transfer support functions set up to facilitate industrial and commercial exploitation of university research results. The specific goal of the project is to explore new ways for the joint exploitation of university knowledge in targeted domains using, best practice and individual experiences from members already engaged in an established pan-European university network, the European Consortium of Innovative Universities (ECIU), and to use this to develop models and pilot actions to show how a group of universities might share resources to make exploitation of research results and transfer to the private sector more effective at a European level.If organisational integration of technology transfer (TT) services by this consortium of universities can be achieved, it will be the first of its kind in Europe and possibly worldwide. In this way DIFUSE could help lay the foundations for actions to be supported at a European level to provide more effective technology transfer from universities as part of the Competitiveness and Innovation programme for Framework 7.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Analysis of Thyroid Hormone Receptor Action in Bone', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Thyroid hormone (T3) acts via thyroid hormone receptors alpha (TRa) and beta (TRb), and is essential for skeletal development and bone mineralisation. T3 excess is associated with an increased risk of osteoporotic fracture and is an important contributor to the morbid and financial burden of disease, although the role of T3 in bone formation and turnover is poorly characterised. The syndrome of resistance to thyroid hormone (RTH) is an autosomal dominant condition that results from dominant negative mutant TRb proteins. Short stature and abnormal skeletal development are prominent features in human RTH. In contrast, TRa mutations have not been described in man and are postulated to be lethal or cause no phenotype. To investigate the mechanisms of T3 action in bone, we will examine bone development in mice with an RTH mutation (PV) targeted to TRb or TRa1 by homologous recombination.Our initial work has shown that TRbPV mice recapitulate human RTH but display skeletal thyrotoxicosis, whilst TRa1PV mice exhibit miled thyroid failure, normal circulating hormone concentrations and skeletal hypothyroidism. Thus, TRa1 and TRb PV mutant mice afford a unique opportunity to characterise T3 action in skeletal cells. In this Outgoing International Fellowship, I will work in two world-leading laboratories in the USA and UK to i) identify skeletal T3-targel genes by RNA microarray analysis and subtraction hybridisation, ii) identify T3-reponse elements in the promoter regions of target genes, iii) characterise the molecular interactions of wild-type and PV mutant TRs at target gene promoters by chromatin immunoprecipitation and iv) analyse the expression of new skeletal T3-target genes in TRa1 and TRb wild-type and mutant mice during development and in response to alterations in thy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Efficient and low emitting propulsion technologies'.

assistant: **Objectives**

As the former thematic network, the aim of the new proposed network PREMTECH is the coordination of the activities of the RTD projects dealing with efficient and low emitting propulsion technologies for IC engines. While the first network was associated with the Auto-Oil I program, the new network takes into account the Auto-Oil II and the new program Clean Air For Europe" (CAFE). The main objective of PREMTECH II is to support the projects on critical technologies (3.1.1) and technology platform (3.3) to resolve the conflict between efficiency and emissions, as opposed to the traditional efficiency/emissions trade-off, in view of the very ambitious carbon dioxide and pollutants emissions targets of 2010- 2012."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'How is blood (re-)made? Regeneration of human hematopoietic stem cells after transplantation' (RESTART) under Horizon Europe.

assistant: **Objectives**

How hematopoietic stem and progenitor cells (HSPCs) regenerate blood is a major unsolved question, frustrating their effective use for therapy. Every year, >40.000 patients receive an HSPC transplantation (HSCT), as a last-resort therapy for various diseases, including leukemia. However, ~40% of HSCT recipients die, due to poor outgrowth of the donor HSPCs, inflammatory complications or relapse. There is an unmet need for strategies to predict and prevent these adverse outcomes. In mice, single-cell methods have revolutionized our understanding of how hematopoiesis is organized, allowing us to control the outcome of murine HSCT in detail. In contrast, our understanding of human hematopoietic regeneration, and our ability to control this process, is lagging behind. As a clinician in pediatric HSCT and stem cell biologist, my mission is to change this. RESTART aims to comprehensively characterize the cellular and molecular mechanisms guiding hematopoietic regeneration in humans. I have pioneered single-cell methods to study human HSPC biology. Here, we will apply state-of-the-art multiomics to dissect the identities and functional states of thousands of HSPCs and their surrounding niche cells in human bone marrow (BM). Embedded in Europe’s largest pediatric cancer center, we will apply these methods to a unique, longitudinal collection of BM samples of pediatric HSCT recipients and their donors, collected before and up to a year after HSCT. Our objectives are: (1) Dissect the cellular and molecular composition of the HSPC population during successful hematopoietic regeneration in human HSCT recipients; (2) Determine how HSCT-induced alterations in BM niche cells affect HSPC fate; (3) Leverage this information to identify and validate single-cell states or trajectories pre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Climate, hydrochemistry and economics of surface water systems'.

assistant: **Innovation**

The overall objective of CHESS is to investigate how expected changes in climate will affect the quality of freshwater resources in Europe. Specific objectives within the project framework are: - To develop and validate a model to represent catchment-based processes and diffuse sources of pollution to river systems. - To develop and validate an in-stream water quality model to represent physical, chemical and biological process in rivers, and point sources of pollution. - To determine techniques for defining the most appropriate scale at which to link catchment and in-stream models, based on available data, knowledge of pollution sources, the overall accuracy required from the model, and limitations imposed by computing resources. - To produce methods of specifying the quality of the freshwater resource in a river system based on existing national and EU use-related standards (e.g. for public water supply, irrigation, industry, and ecological sustainability) and on an economic assessment of the resource value. - To prepare scenarios representing future conditions based on direct effects of climate change (i.e. changes in rainfall, temperature and evaporation), changes in land use and land management that may result from changes in climate, changes in policy and legislation that may have an impact on sources of pollution (diffuse and point sources) and environmental standards. - To apply all of the methods to a set of five catchments representing a transect of European climates to obtain a consistent statement of the current status and value of the freshwater resource, and how this may alter as a result of climate change. These objectives contain significant scientific challenges, and also the development of methodologies that will be exploited throughout Europe. Involve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Communication between immune cells via release of RNA-carrying vesicles: Lessons from viruses' in the context of a Seventh Framework call.

assistant: **Objectives**

Communication between immune cells is crucial for regulating the magnitude and quality of immune responses. A newly uncovered means of intercellular communication involves transfer of small cell-derived vesicles. I recently discovered that vesicles released by immune cells are enriched for small noncoding RNAs, which may act as regulatory RNAs that can influence gene expression in vesicle-targeted cells. Furthermore, remarkable parallels emerged between RNAs abundantly present in cell-derived vesicles and a group of host RNAs specifically incorporated into retroviruses. These shared RNAs may underlie the formation or function of both cell-derived vesicles and retroviruses. Until now, mechanisms behind selective incorporation of small RNAs into cell-derived vesicles and their function in vesicle-targeted cells are poorly understood.Aim of INTERCOM: To resolve how the exchange of small RNAs via cell-derived vesicles contributes to intercellular communication between immune cells. Key objectives: 1. To determine the diversity and plasticity of the RNA content of vesicle subpopulations released by immune cells. 2. To explain functional differences between immune cell vesicle populations based on their RNA contents. 3. To determine the function of structural RNAs shared by immune cell-derived vesicles and retroviruses.Tools in virology research will be used in combination with several high-end technologies, which were uniquely adapted in my lab for vesicle-related research. These include a high-resolution flow cytometric method suited to analyze individual nano-sized vesicles, RNA deep sequencing with previously developed data analysis methods, and super-resolution microscopic imaging.The proposed work advances our understanding of communication processes in the immune syste