RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Virtual and Augmented Environments and Realistic User Interactions To achieve Embedded Accessibility DesignS' (VERITAS) under Seventh Framework.

assistant: **Objectives**

VERITAS aims to develop, validate and assess an open framework for built-in accessibility support at all stages of ICT and non-ICT product development, including specification, design, development and testing. The goal is to introduce simulation-based and VR testing at all stages of product design and development into the automotive, smart living spaces, workplace, infotainment and personal healthcare applications areas. The goal is to ensure that future products and services are being systematically designed for all people including those with disabilities and functional limitations. Specifically, VERITAS will develop:\tAn Open Simulation Platform (OSP) for testing at all development stages that will provide automatic simulation feedback and reporting for guideline/methodologies compliance and quality of service.\tdetailed virtual user physical, cognitive, behavioural and psychological models as well as the corresponding simulation models to support simulation and testing at all stages of product planning and development.\taccessibility support tools at all the stages of iterative planning and development (i.e. specification, design, development, testing, evaluation) and for the five new application areas.\tvirtual simulation environments for ICT and non-ICT products offering tools for testing and verification mainly at the design stage but also during the development stages when links to ICT technologies are implemented.\ta VR simulation environment for realistic and iterative testing providing simultaneous multimodal (visual, aural, etc.) feedback to the designer/developer as well as the potential for immersive realistic simulation and virtual persona testing (i.e. the developer taking the role of the end user).\ta simulation environment that will support multi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enabling Desktop Grids for e-Science' under Seventh Framework.

assistant: **Concept**

Grid systems are currently being used and adopted by a growing number of user groups and diverse application domains. However, there still exist many scientific communities whose applications require much more computing resources than existing Grids like EGEE can provide. The main objective of this project is to support these new communities:<br/>a) by providing the necessary extensions for existing Grid infrastructures to address the specific needs in these new scientific communities within a coherent pan-European model, regardless of the location of their research facilities<br/>b) with the adaptation of their applications to the enhanced Grid infrastructure<br/>c) through the provision of standard APIs and Grid application development tools that facilitate the adaptation of their application to the enhanced Grid infrastructure.<br/>In order to support the specific needs of these scientific communities EDGeS will interconnect the existing EGEE Grid infrastructure with existing Desktop Grid (DG) systems in a strong partnership with EGEE. Service Grids (SGs) like EGEE are more flexible than DGs and can accommodate a broader variety of applications, however, they are much more expensive to maintain. Desktop Grids are currently restricted solely to Master/Worker-style compute-intensive applications but can scale very easily and are able to collect 1-2 orders of magnitude more compute power than most SGs are able to, and at a fraction of the cost. The interconnection of these two types of Grid systems will enable more advanced applications and provide extended compute capabilities to more researchers.<br/>One other objective of EDGeS is to extend the potential user communities for both Grids and Desktop Grids beyond traditional scientists and current volunteer computing pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Self-Assembled Virus-Like Particles from Polyferrocenylsilane-Based Polymers and Viral Capsid Proteins: Fabrication, Surface Engineering and Applications', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The capsid proteins of viruses have been shown to organize around a variety of non-biological polyanions, in a similar way that proteins assemble around RNA genomes, to form virus-like particles (VLPs).  Metal-containing polymers such as polyferrocenylsilane possess additional interesting physical and chemical properties and may yield VLPs possessing very different morphologies and more diverse functionalities on co-assembly with capsid proteins. In a similar manner to almost all nanoscale objects, VLPs generally exist in the solid state but not in the liquid phase, because the scales of these systems are typically larger than the range of attractive interactions between such nanostructures.  This situation comes with limitations regarding both storage and product formulation.  Due to the recent development of liquid proteins via the surface engineering techniques, interest in the phase behavior of bionanomaterials has grown rapidly.  The proposed research focuses on the fabrication and surface engineering of responsive VLPs through the self-assembly of polyferrocenylsilane-based copolymers and viral capsid proteins.  This project is highly interdisciplinary and the project objectives will be accomplished by the proposed award of a Marie Curie Fellowship to a highly talented young scientist from China, Dr. Hongjing Dou. She has considerable expertise in the area of  bionanomaterials and in biomedical science. The proposal involves her working at the School of Chemistry at the University of Bristol in the UK together with Prof. Ian Manners, who has expertise in the field of synthetic metallopolymers such as polyferrocenylsilanes and also self-assembly, and cosupervisor Prof. Stephen Mann, an expert in bio-inspired chemically-derived routes to complex materials and a pion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanism of transmembrane signalling by EGFR', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

According to the latest estimates from the European Cancer Information System, the incidence and mortality from cancer is projected to increase in the next 20 years. Therefore, there is a strong urge to design safe and effective therapeutic approaches to manage cancer progression and ease the burden of the disease. Although the etiology of cancer is highly complex and multifactorial, disruption of the Epidermal Growth Factor Receptor (EGFR) function is commonly associated with the development of several types of cancers. Despite being in the spotlight since its discovery in the late 70’s, several important aspects of EGFR function (e.g oligomerization and receptor bias) still remain largely unexplored. Inspired by this gap of knowledge, the main aim of this proposal is to shed light into the molecular mechanisms governing EGFR oligomerization and signaling. EGFR in dimeric and oligomeric assemblies will be resolved by Cryo-Electron Tomography (Cryo-ET) in near-native conditions. As substantial differences in the transmission of response between dimer and oligomeric EGFR states can arise (receptor bias), these aspects will also be extensively validated/analyzed in vitro. Cryo-ET is revolutionizing the field of structural biology, as proteins can now be resolved without laborious purification protocols which potentially alter structure and function of target proteins. Although promising, this technique is still at early stages of development and only large proteins have been successfully resolved. By resolving the structure of a relatively small and flexible protein, the boundaries of this technique would be expanded and be more applicable for the structural characterization of transmembrane receptors. From the biological point of view, knowing the conditions in which EGF
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Allogeneic Macrophages for Cancer Therapy'.

assistant: **Objectives**

Macrophage cell therapy can become an attractive example of a cell therapy, with numerous potential applications, among them cancer therapy. While T-cell based therapies  so successful for the treatment of hematological malignancies!  have yet failed to demonstrate effectiveness in the treatment of solid tumors, macrophages are a key component of the tumor microenvironment (TME), and in principle they are capable of killing solid tumor cells. However, wildtype macrophages commonly respond to the TME by acquisition of a M2-like polarization state, in which state they rather support tumor growth and metastatic spread. This is a first problem for macrophage cell therapy against cancer. Besides, unlike T-cells, human macrophages cannot be expanded in cell culture, resulting in insufficient numbers of obtainable macrophages and thus limiting their utility for cell therapy.We have generated genetically engineered human macrophages, which have proliferative potential, are resistent to tumor-induced repolarization and thus demonstrate oncolytic activity. We want to translate these exciting findings into a cell-therapy against cancer. ONCOMAC relates to the preparation for and design of a preclinical proof-of-concept study for these genetically engineered human macrophages, so that we will have a sound basis for the translation of our genetically engineered macrophages into clinical trials. In particular, ONCOMAC will establish the numerous complex analytical procedures which are required by the European Medicine Agency's regulatory framework for First-in-human studies of an ATMP (Advanced Therapy Medicinal Product).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The effects of flow topology on dissipation and reaction rates' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content We intend to analyse the effects of flow topology on diffusion processes by performing two sets of numerical simulations. The first.set concerns the Kelvin-Helmholtz instability. We will investigate the space filling properties of the interface between two adjacent streams. The rolling-up of this interface leads to a structure with spiral topology and increases the area of mixed fluids, so that diffusion rates, dissipation rates, reaction rate and combustion rates are very sensitive to this dynamical process. The second set is about a turbulent flow dominated by a single eddy, where interactions between the eddy and the turbulent surrounding flow generates high vorticity zones with well-defined geometry. We will investigate the effect of these structures on dissipation, diffusion and reactive processes. The results of these analyses will be applied to the study and modelling of dissipation and diffusion processes in turbulent reactive flows, shear layers and vertical flows. Both problems will also be used to understand the properties of vortex sheets and vortex filaments in the small scales of turbulent flows. Training content (objective, benefit and expected impact) Our proposal is a collaboration between a theoretical Fluid Dynamics laboratory (DAMTP), and an applied research center involved in Numerical Fluid Dynamics (CERFACS). This exchange will be fruitful for both laboratories.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ocean Night: helping society understand the importance of the marine ecosystem' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Life started in the oceans. Oceans cover the majority of Earth's surface and are the single largest ecosystem on the planet. Billions of humans live in coastal areas and depend on the functioning of this ecosystem to live. Unfortunately, human activities are seriously endangering the health of the marine ecosystem. It is therefore critical to raise awareness of the richness of this ecosystem, its importance, the challenges it faces and what we, as citizens of the world, can do to improve and preserve it through our personal choices. With the MCSA Researchers Night proposal Ocean Night we aim to contribute to this challenge by raising marine science literacy across the general population and promoting the appreciation of the importance of the marine ecosystem.  Our proposal brings together all public Research Institutes across Spain working on marine science for a comprehensive 2-years outreach program. We will leverage the substantial outreach experience of the Institutes to deliver a diverse and coherent program of events aimed at engaging a geographically wide and socially diverse set of regions within Spain.


**Keywords:** marine science,  ecology,  science education,  conservation,  interdisciplinary science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Bacterial Computing with Engineered Populations'.

assistant: **Concept**

The main objective of BACTOCOM is to build a simple computer, using bacteria rather than silicon. Microbes may be thought of as biological micro-machines" that process information about their own state and the world around them. By sensing their environment, certain bacteria are able to move in response to chemical signals, allowing them to seek out food, for example. They can also communicate with other bacteria, by leaving chemical trails, or by directly exchanging genetic information. We focus on this latter mechanism.<br/>Parts of the internal "program" of a bacterial cell (encoded by its genes, and the connections between them) may be "reprogrammed" in order to persuade it to perform human-defined tasks. By introducing artificial "circuits" made up of genetic components, we may add new behaviours or modify existing functionality within the cell. Existing examples of this include a bacterial oscillator, which causes the cells to periodically flash, and cell-based pollution detectors that can spot arsenic in drinking water. The potential for bio-engineering is huge, but the process itself is made difficult by the noisy, "messy" nature of the underlying material. Bacteria are hard to engineer, as they rarely conform to the traditional model of a computer or device, with well-defined components laid out in a fixed design.<br/>We intend to use the inherent randomness of natural processes to our advantage, by harnessing it as a framework for biological engineering. By allowing our system to evolve, we use natural selection to build new functional biological devices. We begin with a large number of simple DNA-based components, taken from a well-understood toolbox, which may be pieced together inside the cell to form new genetic programs. A population of bacteria then abso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'LE coupon based technology' under Seventh Framework.

assistant: **Concept**

SMyle involves mathematical modell ing, design, fabrication and testing of a Shape Memory Alloy coupon undergoing actuated controllrd deformation. It is envisaged that two different SM actuating principles will be pursued. In the first approach the actuator will be embedded in the coupon in the form of an active layer whereas in the second approach the use of the so called compliant mechanisms will be investgated with the SMA wires as actuating elements. Work will be carried out as following: Determination of single-cycle/multi-cycle loading conditions which involve the thermal-mechanical and electrical aspects, with empasis on hysteresis, as well as determination of experimental conditions, i.e. surface uniform- & non-uniform actuation type of loading; prediction of specimen's surface response by means of simple analytic methods. Uniform as well non uniform surfaces of the same SMA specimen will be pursued. Testing will include the deformation to the desired shapes repeatedly and measure reproducibility and attainment of desired shape. The effect of temperature will also be evaluated by completing several actuation cycles at temperatures near the SMA transformation temperature. Commercially available SMA will be used and an initial characrerization phase is foreseen. The aim is to have the material behaviour under static and dynamic conditions up to failure. It is foreseen that for every actuating principle the most promising concepts will be bench-tested to evaluate characteristics and highlight challenges. Up to four concepts will be tested in this context. Eventual modification of numerical model and structural correction of the SMA specimen in case of unsatisfactory experimental outcome will be carried out. Finally, a functional SMA specimen and recommendations for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Assessment of ecocorona acquired by Graphene Family Nanomaterials during exposure to biofilms and fate following uptake'.

assistant: **Concept**

Mass production of graphene and its derivatives (Graphene Family nanomaterials, GFN) is driven by their integration in an increasing number of (consumer) products: by 2020 the global market for graphene is projected to reach US$125 million. Given the serious concerns raised over the potential impact of GFNs on the environment, and in order for graphene-related nanotechnology to develop in a sustainable and responsible manner possible, it is crucial to ensure that development ofGFN takes place alongside research focused on its consequences for public health and potential environmental impacts and unanticipated consequences due to the production, use, recycling, and disposal of GFN. Essential information related to the health and environmental impacts of GFN is either missing or remains incomplete. Specifically, to perform the appropriate nano-risk assessment, there is an urgent need to adapt the environmental risk as¬sessment principles and methodology related to the exposure as well as the hazard assessment. ToxEcoGraphene will address the pressing need to identify the environmental processes that will determine the fate of GFN in the environment, as well as their nanoecotoxicity impacts. The research objectives (RO) of ToxEcoGraphene are: (1) To develop, characterize and utilize well-defined GFN-oriented protocols and methods to facilitate investigation of GFN fate and transport in natural complex media, (2) To determine the effect and evaluate GFN toxicity to biofilms, by focusing on environmental fate processes, mainly on hetero-aggregation and growth of the “eco-corona” on graphene’s surface, and (3) To implement the main research conclusions in order to mitigate identified risks/environmental impact and design-out potential drawbacks/hazards related to GFN technolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'THERAPEUTIC AND PREVENTIVE IMPACT OF NUTRITIONAL LIPIDS ON NEURONAL AND COGNITIVE PERFORMANCE IN AGING, ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA' under Seventh Framework.

assistant: **Concept**

Major objective: It is our aim to develop a lipid based diet that is able to delay or prevent onset of Alzheimer’s disease and related diseases and has a stabilizing effect on cognitive performance in aging. Multiple lines of evidence suggest that there is a large overlap between risk factor of these three diseases. Importantly, there is equally strong evidence that prevention and treatment of these diseases can be efficiently addresses - especially in their first and their priclinical stages - by closely related or identical bio-molecules. Predominantly these molecules appear to belong to the class of lipids which are part of the human diet. However, very often they are consumed in far lesser than recommended amounts. Bearing in mind that all of these diseases have a long pre-clinical phase in which the disease remains undetected specifically designed nutrition may be requirred for effective prevention or for those who already progressed into the first clinical stage of the disease. Moreover, frequently the within the elderly population pathological changes by two or all of these diseases occur in combination thus targeting only one would be insufficient. Taking these aspects into consideration, dietary supplementation, composed to maximize benefit for all three of these in the elderly common diseases, appears to be the most suitable approach to provide a general health perspective improvement for this age group in the EU population.