RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Characterization and HARmonization for Industrial Standardisation of advanced MAterials'.

assistant: **Objectives**

In CHARISMA we propose new concepts to harmonise Raman characterisation of materials, developing hardware and reference master samples; algorithms and protocols for spectra acquisition and computational quantitative analysis; and correlations between Raman data and process or product descriptors. We will support data and models sharing under FAIR principles by defining ontologies for data curation, generating an interoperable Raman dataset valid for Raman systems of different configurations, and developing a web-based platform and API’s (Application Programming Interfaces) adapted to end-users with different levels of expertise and equipment resolution. CHARISMA will enable Raman data sharing across domains and across product life-cycle stages, from product design and manufacturing to performance and end-of-life, including recycling. This will foster the industrial implementation of Raman spectroscopy as real-time, in-line and distributed monitoring and control/decision tool,  improving the bussines of existing products/processes due to improved product quality and trust, waste minimization and time and energy saving. Raman harmonisation will also enable the fast development of new business based on Raman-active nanomaterials that face different societal challenges related to energy, security, or safety. We will demonstrate the feasibility of CHARISMA concept in three markets: chemical processes (production of catalysts), authentication and traceability of documents and goods, and food safety monitoring. In the long term, we aim to make Raman spectroscopy a widespread technology used within the Industry Commons concept, pave the way for harmonisation in optical spectroscopy, and contribute to joint NMBP-related characterisation efforts and projects.


**Keywords:** Rama
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Nit in the Lab-2' to be submitted under Seventh Framework.

assistant: **Abstract**

The main aim of the present proposal is to bring researchers involved in different researcher’s branches closer to the large public, without any distinction of age, gender, level of scientific training or social category. In general, the proposed action intends to oppose the stereotypes about researchers and their profession, giving the opportunity to perceive them as “ordinary people”. In Italy humanistic studies are still preferred to scientific ones. This is a hindering point for the development of research and technology and for the competitiveness of the country and of Europe as well. Therefore, showing researchers “from inside”, stressing his/her “ordinary” features could help in attracting people to scientific careers and rise the perception of the role of researchers in our society. Last year NITLAB was the EU researcher’s night event of Milan and it was successful. This year NITLAB-2 event is proposed. The University of Milan is the coordinator of the project, like as Researcher’s night 2008, with the partnership of the Planetarium of Milan and the Museum of Natural History of Milan. Multiple laboratories activities on paleontology, biology and astrophysics will be organised. Munari’s association, which has developed an international method to combine art and science suggesting activities to the children that can reproduce easily at home, will participate to NITLAB-2 event. Since 2009 is the International Year of Astrophysics special activities, proposed for the first time in Italy, will be organise on the last frontiers of Astrophysics. Drama, buffet, music will give an informal atmosphere. The event will be organised in the beautiful park located in the centre of the city accessible by the subway and close to the Planetarium of Milan, one of the oldest in Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Anosognosia and delusions in the diseased brain' (UnaWireD), addressing dissemination and exploitation.

assistant: **Impact**

Why is the diseased human brain able to produce false beliefs that persist despite evidence to the contrary? Unawareness of neurological disturbances (anosognosia) and Delusions are examples of such false beliefs. Both have productive, narrative features. Both have been independently linked to processes involved in self-reflection, metamemory, and error-monitoring. Despite their phenomenological similarities, the research investigating their mechanisms has progressed independently. UnaWireD will provide the first in-depth investigation of anosognosia and delusions in combination to test the hypothesis that they share common brain mechanisms. Although these symptoms impact significantly on a range of brain disorders, the proposal focuses on Alzheimer’s Disease (AD), in which the difference between patients who show the most severe form of these symptoms and patients who never present them is striking yet largely unexplained. In particular, it is not known whether these symptoms represent a response of the spared brain to the damage (depending on pre-existing vulnerability or resilience) or are a consequence of the damage itself (depending on type, localisation and severity of pathology). By combining advanced imaging with experimental paradigms and extended clinical and biomarker characterisation, UnaWireD will: 1. Establish whether anosognosia and delusions define a specific clinical subtype in AD; 2. Determine if they are associated with premorbid personality and cognitive abilities; 3. Identify the brain networks specifically altered in the anosognosia/delusion AD subtype;4.Test if anosognosia is associated with an imbalance in the brain neurotransmitter dopamine.UnaWireD will deliver a new framework to study the interplay between the spared and damaged brain in the o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Personalized medicine in ovarian cancer: Design and development of a tool for response prediction to targeted platinated nanocarrier-based treatments' under Horizon Europe.

assistant: **Concept**

Personalized treatments are considered major challenges in clinical practice. They become particularly critical for diseases with poor prognoses diagnosed at later stages, such as ovarian cancer. Here, the vague symptoms, the lack of reliable screening tools and the treatment resistances have made this cancer the most lethal gynaecological malignancy (40% 5-year survival rate; 50-90% recurrence rate). Thus, ovarian cancer patients would certainly benefit from improved therapies and appropriate treatment choices. In this regard, the present OvaCTool project aims at developing a highly sensitive mass cytometer-based tool for the prediction of treatment response against newly designed targeted nanocarriers for platinum (Pt)-based chemotherapy in ovarian cancer. Specifically, diverse iron-based nanocarriers for Pt (IV) prodrugs targeting ovarian cancer cells will be evaluated. Such assessment will also include the understanding of ovarian cancer proteome changes after therapy. All this information will then be integrated to define biomarkers of treatment response which will be combined in a mass cytometry panel (up to 50 markers) together with proteins to identify other cells from the tumour microenvironment aiming at the stratification of patients into responders vs non-responders to the newly designed drugs. Likewise, protein corona formation on the nanostructures will be investigated to recognize potential challenges after intravenous injection of the drug in the clinical setting. In summary, this project will provide potential enhanced anticancer drugs and a prediction tool for targeted treatment choices which will help towards better survival rates for this malignant disease.


**Keywords:** Ovarian cancer, platinum nanodelivery system, treatment response prediction to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineered Sequence-Specific RNases: New Reagents for RNA biotechnology' (ERNASES).

assistant: **Innovation**

The basic idea to be taken to the proof of concept is creation of novel molecular biology tools, ie. enzymes acting on DNA/RNA hybrids and dsRNA that are able to cut the RNA strand(s) in a site specific manner. We have already created prototypic proteins of those two classes of ‘RNA restriction enzymes’ and performed initial steps towards commercialization of the project. We are applying for funding to 1) ensure the best available patent protection, 2) finish the prototypes and validate the approach and 3) perform detailed market research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Complex mechanical response of silica-based amorphous materials: from the atomic to the mesoscopic scale'.

assistant: **Innovation**

This project focuses on the study of the mechanical behaviour of silica-based amorphous materials, which have attracted the interest of the scientific community both for their intrinsic physical properties and for the possibility to use them in technological applications, for example in micro- and nano-electronic devices, coatings and glasses. The mechanical response of amorphous materials, such as silica and silicate glasses, is still under investigation and it has not been fully understood yet because of the difficulty to visualize the microscopic rearrangements at the atomic scale. For example, the plastic response cannot be described in terms of dislocations as in crystals. Moreover, the small-scale response can be responsible for the macroscopic mechanical properties, like e.g. plastification, rupture and densification, but a clear link between the atomic-scale behaviour and the macroscopic phenomenology has not been established yet.Therefore, the aim of the project is to obtain an accurate and realistic theoretical description of the elastic and plastic response of silica-based amorphous materials by using complementary numerical techniques, trying to identify the relevant physical mechanisms of the response from the atomic to the mesoscopic length scale. We will propose a multi-scale modelling of the mechanical behaviour of these materials by performing Molecular Dynamics calculations at the nanoscale and finite-element calculations at the micrometer scale. The obtained results will be compared to experimental results found for different glasses and for several mechanical deformations. In this way we will provide a unifying description of these systems at different length scales and we will analyze the microscopic foundation of their phenomenological behaviour, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'HYbridization via Parallelization based on NOvel Topologies for Innovative Converters' to be submitted under Horizon 2020.

assistant: **Abstract**

The main objective of HYPNOTIC project is the development of a set of bidirectional converters (at least 5), acting together as only one equipment. Specifically the equipment, composed by several DC/DC bidirectional converters (i.e., the “modules”) plus a supervisor, must be able to reconfigure itself as a consequence of load/source variations, referring to their characteristics and priority, and as a reaction to a fault or to other undesirable events, hence contributing to the maturity of any HVDC distribution Network. This modular architecture will support the design of a scalable converter (30 to 60KW) which could be used to support the integration of new HVDC sources. The HYPNOTIC converter will be connected to HVDC network of the aircraft on one side and to a HVDC battery on the other side which will provide an energy storage source. The converter will implement relevant control techniques to ensure the stability of the network and the battery, and to allow a smooth energy transfer in both directions. Hence, the scope of the project can be summarized as the design and development of a modular bi-directional converter, composed by hardware and software acting together in order to solve the Power Transfer problem of additional DC sources in any HVDC network. Objectives of HYPNOTIC project include: - Development of DC/DC converter cells with enhanced performances, including power density and reconfiguration capabilities. - Development of accurate simulation models, at both “behavioural” and “functional” levels, potentially also integrated with external environments for the aims of the energy management functionalities verification. - Implementation of reliable control laws to allow the parallelization of several HVDC sources - Demonstration of the operation of such co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Synbio for cOmpartmentalized caRotenoids sToragE in Diatoms' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Carotenoids, prized for their antioxidant properties, are essential precursors for crucial human vitamins and, in plants and algae, they play roles in light absorption and photoprotection against excessive light-induced damage to photosynthesis. However, it is very challenging to achieve carotenoid market- required yields. Carotenoids complex chemical synthesis in fact, limits the possibility to obtain them artificially while in plants (i.e., the main natural producers) excessive carotenoids in chloroplasts can disrupt thylakoid membranes, making biotechnological manipulation aimed to increase carotenoid yield particularly hard.To address this problem, a sustainable approach is crucial, and microalgae offer a promising solution as natural, scalable carotenoid producers. A novel strategy involves repurposing cellular factories to overcome chloroplast limitations for carotenoid biosynthesis and accumulation. Diatoms, like Phaeodactylum tricornutum, are ideal candidates due to their multiple cellular compartments, including the periplastidial compartment (PPC), suitable for carotenoid storage, and access to precursors synthesized through various cellular pathways.Moreover, diatoms excel as synthetic biology platforms with efficient genetic tools, modular DNA assembly, and genome editing capabilities.The SORTED project aims to advance understanding through a multifaceted approach. Firstly, we will investigate prenyltransferases (PTSs) in P. tricornutum's cytosol to unveil their role in carotenoid precursor synthesis (Objective 1). Subsequently, rational redesign will enable the extraplastidial relocation of the carotenoid biosynthetic pathway (Objective 2). Furthermore, we will assess the physiological implications of genetic modifications on performance (Objective 3). Thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Crystallization and structure determination of adrenergic G protein-coupled receptor subtypes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Crystal structures of beta1 and beta2 adrenergic G protein-coupled receptors (GPCRs) have been determined recently. We propose to extend the structural information about this physiologically and medically important GPCR subfamily by obtaining the structures of the beta3 and the alpha adrenergic receptors. The ample experience in GPCR structural biology of the host laboratory, complemented by its multidisciplinary approach, provides an ideal environment for this challenging task. We will make use of high-throughput facilities and methods to optimize the receptor constructs for expression and protein stability. We will use various crystallization methods and available robotic nano-liter dispensers to determine suitable conditions for crystal growth. We will have access to state-of-the-art microcrystallography beamlines at the Swiss Light Source synchrotron at Paul Scherrer Institut (PSI) to test a large number of obtained crystals and collect the best possible diffraction datasets. Once diffraction data of sufficient quality has been obtained, the structure will be solved by molecular replacement. In collaboration with other PSI scientists and external academic and industrial partners we will use the structural results obtained for the adrenergic receptor subtypes to study the structural basis of ligand efficacy, i.e. how the process of ligand binding is translated into receptor function, and to find applications in therapeutic drug development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SCIENCzEch 2021: Time for Change' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

SCIENCzEch 2021: Time for Change is a proposal of The European Researchers? Night in the Czech Republic in 2021. The common main objective of the European Researchers' Night is to give public and local communities the opportunity to meet with researchers, learn about their passion for science, the motivation that inspires them, the methods they use, and the results they achieve. It opens doors to the places where scientists work and also brings research to unusual places. At this event children, young people and adults can get insights into research work, careers and what kind of cutting-edge technology is used in modern research. The specific objective of the event is to show research careers as interesting, enriching and useful job that might entail a career path for everyone and to motivate and inspire the youth to enjoy, understand and pursue science and technology. One of the political priorities of the European Commission is the European Green Deal for the European Union and its citizens, with an aim to tackle climate and environmental-related challenges. This strategy and series of initiatives that will protect the environment, boost the green economy and improve the well-being of people under the European Green Deal for the European Union and its citizens will be promoted by a wide range of activities during the ERN 2021. . ""The TIME"" with subtitle ?TIME for Change? is going to be the main topic for the Researchers' Night in 2021. The topic refers to the to time in many ways. We are in a time of change, the situation with COVID-19 has shown us how vulnerable a global society is. At the same time, we are facing problems linked to climate change and environmental crises. We question how much time is left for our planet and how to deal with this time responsibly.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Optimal Design and Operation of Microbial Ecosystems for Bioenergy Production and Waste Treatment'.

assistant: **Concept**

Many microbial ecosystems, as part of their normal activity, have the potential to provide services to society and improve environmental quality. Some can degrade contaminants that pollute water, air or soil. Others can transform waste materials into valuable renewable resources, including bioenergy, biomaterials and high-value products. This generic capability opens the possibility for combining several microbial ecosystems in integrated bioprocesses or biorefineries, where various types of bioenergy or biomaterials are produced and multiple sources of pollution are treated, all at the same time.The focus in the DOP-ECOS project is on bioprocesses that couple a photobioreactor, where microalgae capture sunlight to produce new biomass and lipids, and an anaerobic digester, where bacteria convert biomass into biogas and recover nutrients. The general objective is twofold: (i) optimize the design, operation and control of integrated microalgal/bacterial processes; and (ii) develop the supporting methods and tools for their reliable analysis and optimization.While experimental research and demonstration programs are carried out worldwide to identify suitable algae strains and expand algal biofuel production from a craft to a major industrial process, the DOP-ECOS project is the first of its kind to apply a systematic, model-based methodology in order to determine optimal design and operation strategies. The need to account for operational issues at an early design stage is particularly pressing for integrated microalgal/bacterial systems, where the operation is expected to have a profound influence on the process design, due to the intricacy of the biological and physical processes involved. Because of the large uncertainty and variability inherent to microbial ecosystems,