RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Intracellular Action of DNA-based Nano-materials' under Horizon 2020.

assistant: **Concept**

Self-organization of matter into structured architectures with emerging functionality is arguably the most important phenomenon to enable life. Unfortunately, human efforts to successfully engineer materials that control hierarchical order and achieve precise action in cells, have suffered from structural heterogeneity and limitations in functional precision. Immune pathways are prime examples of cascades where a finely balanced sequence of interactions decides between life-changing outcomes, varying from tolerance to active fight. Immune-modulating materials, therefore, would uniquely benefit from precision control over functionality. DNA-based nanomaterials have the potential to change our current bioengineering standards due to their inherent architectural uniformity and nanometer control of functionalization, allowing for a quantitative analysis of material parameters on cell activation.   The goal of this ERC proposal is to use structural geometry of DNA-based materials to provoke controlled intracellular manipulation of immune signaling via the hierarchical and spatial organization of constitutive DNA binding proteins. We create a circular paradox where DNA defines protein synthesis, yet protein function is controlled by self-organization following interaction with designer DNA. Our approach stands out in its controlled-by-nature strategy: 1) we exclusively use materials derived from cellular building blocks; that 2) respond to stimuli generated without artificial intervention, 3) that we quantify using pathway specific activation markers and 4) image via label-free microscopy to track inherent structural changes in physical material properties. We apply our approach on two important signaling pathways involved in immunology: TLR9 as Th1 trigger for vaccine adjuva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Diagnostics device for rapid testing of prostate cancer at Point-of-care'.

assistant: **Objectives**

Prostate cancer (PCa) is one of the most common types of cancers. As an age-related disease, it is very infrequent below the age of 40 but very common above 65. Currently in Europe, 1 in 7 men will develop PCa before reaching age of 85. With population growth and ageing, the numbers of PCa diagnoses and PCa deaths are likely to substantially increase. It is estimated that by 2030, with an increase in the proportion of people over 65, the number of PCa cases will quadruple. Most PCa’s are first found through a prostate-specific antigen (PSA) blood test. Under the current standard of care, men with an elevated PSA levels and/or abnormal digital rectal exam (DRE) are considered at high risk for cancer and will be referred to a urologist for a biopsy. But most men selected for biopsy could have avoided this painful procedure, with its associated complications and costs. More accurate non-invasive tests could help PCa-free men safely avoid unnecessary biopsies, while helping to identify men who may be harbouring aggressive PCa, who will benefit from earlier detection. In response to this challenge, we have developed Nevada, a non-invasive urine-based test assay that identify those men at increased risk of PCa who may benefit most from earlier detection. We plan to convert our test into a Point of Care assay, resulting in significant savings for the healthcare systems across Europe, by only referring those patients to the hospitals that are at risk for a clinically significant cancer. Upon completion of the project, Nevada will boost the growth of our company generating additional 85 FTEs, revenues of €309M and a ROI of 7.9 by the fifth year after Phase 2 execution. With the help of the SME instrument, MDxHealth aims to complete clinical validations and assay optimization so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Tail asymptotics for random walks and queues' under Sixth Framework.

assistant: **Concept**

We propose to investigate three important problems. Namely, we are interested in tail asymptotics for the busy period in the single-server queue, tail asymptotics for the stationary sojourn time in the processor sharing queues and tail asymptotics for the supremum of the random walk with dependent (asymptotically) stationary increments. We plan to study both heavy-tailed and light-tailed cases. In this research we will use theory of large deviations of random walks and we also intend to make a contribution to this theory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Invisible metal contacts for solar cells – boosting power output while cutting costs'.

assistant: **Innovation**

Solar cells use metal contacts to convert sunlight into electricity. Flat metal contacts typically cover 5% of the solar cell front surface, blocking some incoming sunlight from reaching the active area of the solar cell. This shading loss is the largest single contributor to performance loss in 95% of commercial solar cells. ExcellenceETC Solar has developed Effectively Transparent Contacts (ETCs) that eliminate shading losses. Unlike incumbent technologies, our patented ETCs efficiently redirect sunlight back to the active area of solar cells. ECTs achieve optical transparency of 99.9%, offer excellent conductivity and boost solar cell power output by 5%:  they are the world’s highest performing front contact technology. We developed and built a specialist printing tool to integrate ETCs directly onto solar cells. ImpactIn this project, we will commercially launch ETCs in our beachhead market, III-V solar cells – widely used in satellites, aerospace, cars and consumer products. We will sell the ETC printing tool directly to solar cell manufacturers. The total III-V solar cell market size is €9BN; the Serviceable Addressable Market is €235M, plus annual recurring revenues of €36M for consumables. Implementation The founding team includes experts in solar energy the US and Europé, and the founder of the world’s largest III-V solar cell manufacturer. This project will transition our working prototype into commercial production. Our global sales funnel already includes two conditional orders, four ongoing customer pilot tests and 19 potential customers who have expressed strong interest in adopting ETC technology.


**Keywords:** Screen printing, grid contacts, manufacturing tools, imprint lithography, alignment, solar cell efficiency, light management, shading losses, co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Theory and principles of luminescent organic radical materials for OLED and sensor applications' under Horizon Europe.

assistant: **Concept**

Organic luminescent radicals (OLRs) are quite rare emitters demonstrating doublet-doublet fluorescence and having a number of advantages towards practical applications in organic light emitting diodes (OLEDs), ratiometric fluorescence sensors and anti-counterfeiting labelling. The doublet-doublet fluorescence by OLRs is a spin-allowed process similarly to the common singlet-singlet fluorescence. But in contrast to closed-shell molecules for which “bright” excited singlet states are higher in energy than “dark” triplet states, the doublet excited states of OLRs are always lower in energy than the quartet states. That is why the theoretical limit for internal quantum efficiency of OLR-based OLEDs is expected to be 100% and why the quartet excited states in general have not been considered for OLRs. However, recent experimental studies indicate that quartet states of OLR emitters indeed can be populated in OLEDs so reducing their efficiency. Thus, in the current project I aim to develop general theory and principles of OLRs in order to involve quartet states into the emission process and to boost the efficiency of OLEDs beyond state-of-art results.Another challenge for this project is design of OLRs for sensor applications. Most of OLRs possess low-lying first excited doublet state that makes them perfect anti-Kasha emitters for which emission occurs from higher excited states, something that is rare for closed-shell systems but required for ratiometric fluorescence sensors. In this project I aim to extend the principles of anti-Kasha emission for OLRs to make a breakthrough in state-of-art ratiometric detection of radicals. Finally, the special kind of sensing called two-step anti-counterfeiting labelling will be developed in this project based on photoresponsive aromatic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Structure of Learner Language' in the context of a Fifth Framework call.

assistant: **Objectives**

The overall goals of these two conferences are to attain a better understanding of second language acquisition after childhood, and in so doing, to contribute original insights to our understanding of the human language capacity. Two EURESCO conferences (1996 & 98) organised on the topic have gone some way towards achieving these goals, and it is indented to consolidate this effort. The previous meetings analysed empirical findings for the acquisition of a number of European languages, and a consensus emerged as to what the relevant descriptive generalisations over second acquisition (SLA) are.A strong motivation for proposing two further meetings is that there is much less consensus on the relative importance to be given to different theoretical explanations for second language acquisition. Now is a very timely opportunity, after three decades of intensive and largely European empirical research, to test the explanatory power of different theoretical approaches on agreed, and crucial, sets of data and, furthermore, to test the generality of the SLA results by asking outside experts to critically discuss them. On a more concrete level, this involves building a platform where European second language acquisition research findings can also be discussed by theoretical linguists, experimental psycholinguists and first-language acquisition researchers. Such an interdisciplinary approach is essential to the enterprise, and provides, moreover, an ideal context for young researchers to appreciate the broader questions facing the linguistic sciences (see Training Content).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A NEXT-GENERATION, SECURE LINKED DATA MEDICAL INFORMATION SPACE FOR SEMANTICALLY-INTERCONNECTING ELECTRONIC HEALTH RECORDS AND CLINICAL TRIALS SYSTEMS ADVANCING PATIENTS SAFETY IN CLINICAL RESEARCH' to be submitted under Seventh Framework.

assistant: **Abstract**

The vision of the proposed Linked2Safety project is to advance clinical practice and accelerate medical research, to improve the quality of healthcare, benefiting public health, and to enhance patients' safety; by providing pharmaceutical companies, healthcare professionals and patients with an innovative semantic interoperability framework, a sustainable business model, and a scalable technical infrastructure & platform for the efficient, homogenized access to and the effective, viable utilization of the increasing wealth of medical information contained in the EHRs deployed and maintained at regional and/or national level across Europe, dynamically interconnecting distributed patients data to medical research efforts, respecting patients' anonymity, as well as European and national legislation.The 36-month Linked2Safety project with the developed reference architecture, data protection framework, common EHR schema, lightweight semantic model and integrated platform will facilitate the scalable and standardized semantic interlinking, sharing and reuse of heterogeneous EHR repositories, which will provide healthcare professionals, clinical researchers and pharmaceutical companies experts with a user-friendly, sophisticated, collaborative decision-making environment for:a.\tanalyzing all the available data including the genetic, environmental and medical history of subjects that exhibit adverse events occurring in the frame of clinical trials, based on the clinical care information existing in the specific patients' EHR, leading to the identification of the phenotype and genotype factors that are associated with specific adverse events and thus having direct impact on the patient safety through the early detection of potential patient safety issues.b.\twide identificatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative solution for maintenance and storage of Biospecimens at Room Temperature' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Historically focused on educational and research purposes, biospecimen preservation has evolved in terms of complexity and demand due to the most recent developments in biomedical research and therapy design which established a trend towards an era of personalized medicine. This is supported by emerging fields, such as genomics and proteomics, which are dependent on the availability of rep-resentative numbers of high quality biospecimens. This puts an extra pressure on the biobanks whose major pain-point is the maintenance cost associated with the increasing numbers of specimens stored.300K’s value proposition statement is “Unplug your sample storage” and we propose to offer all the products and knowledge needed to stabilize and store biological material at RT conditions. The primary benefits are the significant reduction in sample storage maintenance costs and the reduced risk of sample loss or degradation. The 300K’s proposal is unique since it is flexible in terms of sample formats, volumes and quantities that can be stored. The first market application for this solution is the storage of specimens for biological and biomedical research. This is usually performed by dedicated biobanks and this solution will make their work more efficient and cost effective. Nevertheless, this technology can also be used for other market applications being the industry of food production (agri-culture and livestock) the one that may benefit the most with this solution and will, most likely, be our main target as a secondary market application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Geant Network' (GN1).

assistant: **Concept**

Geant will provide pan-European interconnection between National Research and Education Networks (NRENs) in Europe at Gigabit speeds, based on direct access to optical connectivity where this is available in the market. Core connectivity procured will be 2.5 Gbps, enhanced to tens of Gbps, as soon as possible. The network will be extended from the current geography of TEN-155 to include connectivity to Cyprus, Israel and Poland and to extend it to Bulgaria, Estonia, Latvia, Lithuania, Romania and Slovakia. Services will include a standard IP service, a premium IP service, a Guaranteed Capacity Service and Virtual Private Networks. Multicast and, later, new value-added services arising from networking developments will also be offered. A European Distributed Access will provide connectivity between European researchers and their counterparts in other world regions.OBJECTIVESThe key objective of Geant is to provide a very high performance, advanced, pan-European network service interconnecting the services provided by Europe's National Research and Education Networks (NRENs). It will support the development activities of the European research and education community, including the development of new advanced applications and the exploitation of new networking capabilities. Geant will create a ubiquitous infrastructure interconnecting the participating NRENs based on shared core connectivity operating at 2.5 Gbit/s initially and in the range of tens of Gbit/s within four years. It will maintain and develop a stable and dependable set of services on which a large and diverse end user community can rely. Geant will initiate a set of service developments that are needed to provide predictable Quality of Service. Consistent operational procedures will be set up to manage QoS m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanism of Enzyme Rhodopsin Activation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Channelrhodopsin, which was discovered and described as a light-gated ion channel in my laboratory, has revolutionized the field of neuroscience over the past decade by enabling researchers to specifically activate selected neurons in a large ensemble of neuronal cells with short light flashes, a technology we now call ""Optogenetics."" However, though highly desirable, the inactivation of specific cells using moderate or low light intensities is not yet possible. The recently discovered rhodopsin-guanylyl-cyclase (RhGC) of the fungus Blastocladiella emersonii offers an elegant solution to this problem. Moreover, RhGC is a totally novel and uncharacterized sensory photoreceptor, and the first member of an enzyme rhodopsin family that urgently awaits in-depth characterization. Accordingly, the goal of the “mechanism of enzyme rhodopsin activation” (MERA) proposal is to obtain a comprehensive understanding of this novel photoreceptor, and to determine its functionality for broad application in optogenetics and other research fields. The MERA project is subdivided into four objectives. The first objective is the characterization and engineering of RhGC in cell lines and neurons as well as coexpression of RhGC with a cGMP-gated K+ channel to develop a ""Light-Hypopolarizer"" for cell inactivation. The second objective is to understand the dynamics of RhGC using a variety of biophysical technologies including time resolved UV-vis, FTIR, and Raman and EPR spectroscopy. A third objective is the generation of crystals for X-ray crystallography and the development of a three dimensional RhGC model. The fourth and final objective is the computer-aided conversion of RhGC into a rhodopsin-phosphodiesterase (RhPDE) for down-regulation of the second messenger cGMP and/or cAMP using l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Climate Resilient Orphan croPs for increased DIVersity in Agriculture'.

assistant: **Innovation**

Agrobiodiversity is a vital subset of biodiversity and is the result of the interaction between the environment, genetic resources and management systems used by culturally diverse people. It is a crucial prerequisite for ecologically and economically sustainable agricultural systems and is an important tool for ecological intensification. The aim of CROPDIVA is to reinforce agrobiodiversity on different levels and along distinct geographic and socio-economic areas. The activities of CROPDIVA are clustered around five connected research work packages and three pillars, each with a set of specific objectives: i) promotion of six key underutilised arable crops: oats, hull-less barley, triticale, buckwheat, faba bean and lupin; ii) creation of value chains for selected underutilised crops ; and iii) study of the socio-economic impact of project results. The concept of CROPDIVA is an innovative challenge driven approach based on the promotion of underutilised crops in sustainable cropping systems and new regional value chains. Project activities will focus on the following major challenges: improved resilience of cropping systems, alignment of the economic and social needs of farmers with ecological goals as well as marketing of new food/non-food products meeting consumer demands. The results gathered in CROPDIVA will not be descriptive, but will be used for innovative solutions along the entire food and non-food chain to enable biodiversity management on all levels, including diversifying the use of genetic resources, crop production systems, new food/non-food products, market opportunities while satisfying producers and investigated consumer requirements.


**Keywords:** food technology; feed technology; market analysis; novel value chains