RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Experiment to Unearth the Rheological Oceanic Lithosphere-Asthenosphere Boundary'.

assistant: **Innovation**

Plate tectonics has been a fundamental tenet of Earth Science for nearly 50 years, but fundamental questions remain, such as where is the base of the plate and what makes a plate, “plate-like?” A better understanding of the transition from the rigid lithospheric plate to the weaker mantle beneath – the rheological lithosphere-asthenosphere boundary (LAB) - has important implications for the driving forces of plate tectonics, natural hazard mitigation, mantle dynamics, the evolution of the planet, and climate change. There are many proxies used to estimate the depth and nature of the base of tectonic plates, but to date no consensus has been reached. For example, temperature is known to have a strong effect on the mechanical behaviour of rocks. However, it has also been suggested that the chemical composition of the plate provides additional strength or that melt weakens the mantle beneath the plate.We are at a critical juncture where large-scale efforts using geophysical, geochemical, and geological techniques are being launched to better understand the definition of the tectonic plate. The simple and short history of the ocean plate makes it the ideal location to advance our understanding. However, imaging the oceanic LAB has proved challenging given the remoteness of the oceans and associated difficulties in instrumentation. Most observations come from only one ocean, the Pacific, from indirect, remote observations, at different areas and scales.I propose a large-scale effort to systematically image an oceanic plate beneath the Atlantic from birth at ridge to 40 My old seafloor. I will deploy ocean bottom seismometers (OBS) and magnetotelluric (MT) instruments, and I will image the plate at a range of resolution scales (laterally and in depth) and sensitivities to phy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Cost effective modernisation of systems important to safety'.

assistant: **Innovation**

The specific technical objectives of CEMSIS are to:1. Develop a safety justification framework for the refurbishment of SIS that is acceptable to different stakeholders (licensing bodies, utilities) within the Members States;2. develop methods for establishing the safety requirements for control system refurbishment and develop an associated engineering process;3. Develop justification approaches for widely used modern technologies, i.e. -COTS products and graphical specification (logic diagram) languages;4. evaluate these developments on realistics examples taken from actual projects;5. disseminate the results of our work to plant operators and regulators within the EU.The main actual deliverables of the project are as follows, and these are discussed in more detail below:D1 Safety Justification Framework for Licensing Software in Nuclear Power Plants;D2 Requirements Engineering Best Practice Guide for Refurbishment;D3 Design guidelines for systems important to safety based on pre-existing products;D5.5 Summary report on case studies;D5.6 Public Domain Example Report;D6 Open Workshop in association with FISA2003 held in Luxembourg on 13 November 2003.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of Themis1, a new T cell signaling protein, in normal and pathological immune responses' (THEMIS) targeting Seventh Framework.

assistant: **Abstract**

A critical step of an immunological response is the activation of T lymphocytes through intracellular signaling pathways downstream of T cell receptors (TCR). THEMIS1 is a new actor of T cell signaling that belongs to a newly identified family of proteins. THEMIS proteins each contain a previously uncharacterized globular domain (called 'CABIT') whose structure and function are currently unknown. We generated THEMIS1 knockout mice and show that this protein is essential for developing T cells in the thymus. THEMIS1 is also express in CD4+ and CD8+ peripheral T cells. Since very few T cells egress to peripheral organs in THEMIS1 knockout mice, little is known about this protein during immune responses. THEMIS1 has recently been pointed out as a susceptibility factor in Celiac disease and Multiple sclerosis, and recent study in rats also revealed that THEMIS1 deficiency leads to the development of spontaneous inflammatory bowel disease. Whether this results directly from THEMIS1 deficiency in T cells or is a secondary effect due to the decrease numbers of T cells in lymphoid organs (lymphopenia) needs to be resolved. The objective of the present proposal is: 1) to perform a structural and functional analysis of THEMIS1 CABIT domains and to establish THEMIS1 interactome in T cells, 2) to determine the physiological and cellular role of Themis in peripheral T cells, 3) to study the contribution of Themis on the development of autoimmune and inflammatory diseases using experimental murine models. I discovered THEMIS proteins during my post-doctoral research at the National Institutes of Health (Bethesda, USA) and I have recently established a lab in France (sponsored by the French government) to pursue our researches on this new family of molecules. Additional supports are n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Flight Critical Wireless Slip Ring for Civil Tiltrotor' to be submitted under Horizon 2020.

assistant: **Abstract**

Slip rings for transferring power and data commonly form the interface between a rotating environment and a stationary domain. For aerospace applications, currently only conventional slip rings, with brushes, are on the market. The technique is proven, fairly reliable and robust, but there are clear drawbacks: wear, size and compromised signal integrity due to electrical noise.  A few commercial wireless slip rings are now available, however not designed and certified for aerospace applications. Flight-critical applications in harsh environments require a fault-tolerant design. The future need for qualification has to be taken into account from the start of the development.The call for proposal asks for the development of wireless slip rings for power and data transfer for a flight-critical application within the Next Generation Civil Tiltrotor (NGCTR). This CfP is a technical and industrial challenge, which provides an opportunity for improving competitiveness on this important improvement part of the NGCTR program of the CS2 work plan.For the development of Constance, NLR will combine their tiltrotor experience from the FP5 TILTAERO and FP7 NICETRIP programs with their patented wireless slip ring design and knowledge from the Contra-Rotating Open Rotor project of the CS2 Smart Fixed Wing Aircraft program. The distinguishing feature of the Constance slip ring is the specific orientation of the rotor and stator parts of the contactless slip ring which makes the design mechanically robust, safe and fault tolerant up to high rotational speeds. For the extension towards the flight-critical application on the tiltrotor the expertise of DDC Electronics Ltd. on power converters will be fully incorporated into the proven technology.   In Constance, three redundant slip ring as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Manipulation of a Single Spin in a Superconductor' (MASSS).

assistant: **Concept**

I propose to perform the coherent manipulation of the spin of a single superconducting quasiparticle.To achieve this challenging goal I will fabricate a Josephson weak-link coupling two superconducting electrodes through the two-dimensional electron gas of an AlSb/InAs/AlSb quantum well. The weak-link configuration allows to single out one superconducting quasiparticle, by trapping it in a low-energy discrete state (an Andreev bound state) completely disconnected from the continuum of excitations above the gap. The energy of this state depends on the superconducting phase difference across the link. It can be tuned by placing the weak-link in a superconducting loop threaded by a magnetic flux.The combination of a finite superconducting phase difference and the strong spin-orbit coupling energy in InAs lifts the degeneracy of the two spin states of the quasiparticle, which can therefore be addressed.In order to manipulate and probe the quantum state of the spin of the trapped quasiparticle I will couple this hybrid structure to the electromagnetic field of a microwave resonator in a circuit quantum electrodynamics (cQED) architecture.This project opens a new research path in the field of superconducting spintronics and leads to the exploration of new topological phases in multi-terminal devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flexible Control Systems Development and Integration Environment for Distributed Systems' (FLEXICON), addressing dissemination and exploitation.

assistant: **Impact**

The objective of this project is the development of a toolset for integration of Open, high performance, dependable, distributed fault tolerant control systems in reduced timescales and at lower cost. A major inhibiting factor to the adoption of Open distributed control systems is that tool support is proprietary to a manufacturer's products. This makes integration of systems using Commercial Off-The-Shelf (COTS) components from different manufacturers difficult. The FLEXICON toolset will address management of requirements, management of complexity, performance assessment via multidisciplinary co-simulation prior to implementation and management of component obsolescence for applications with a 10-30 year lifetime. Two distributed control systems demonstrations will be used to provide a focus for the work; a heat treatment line and marine gas turbine engine/waterjet propulsion.Work description:Rapid advances have been made in Commercial Off-The-Shelf Programmable Logic Controllers (PLCs), PC-based boards and embedded intelligence in localised smart controllers, smart sensors and smart actuators. Great opportunities exist to produce high performance, dependable distributed systems, however, the key element that is missing is software tool support for systems integration. Many proprietary tools exist for programming specific manufacturers products, however, code cannot be reused on another manufacturer's equipment. This is currently the major inhibiting factor to the uptake of Open Distributed Systems.The objective of FLEXICON is to provide an integrated suite of tools to support all the development life-cycle phases: simulation/modelling, development and implementation, addressing:- Management of requirements Management of complexity;- Performance assessment during desig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ENERGY use for Adaptation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

ENERGYA will improve our understanding of how energy and energy services can be used by households and industries to adapt to the risk posed by climate change. Specifically, the project will develop an interdisciplinary and scalable research framework integrating data and methods from economics with geography, climate science, and integrated assessment modelling to provide new knowledge concerning heterogeneity in energy use across countries, sectors, socioeconomic conditions and income groups, and assess the broad implications adaptation-driven energy use can have on the economy, the environment, and welfare.The key novelty of ENERGYA is to link energy statistics and energy survey data with high spatial resolution data from climate science and remote sensing, including high-resolution spatial data on meteorology, population and economic activity distribution, electrification, and the built environment.ENERGYA has three main objectives. First, it will produce novel statistical and econometric analyses for OECD and major emerging countries (Brazil, Mexico, India, and Indonesia) to shed light on the underlying mechanisms driving energy use. Second, it will infer future potential impacts from long-run climate and socioeconomic changes building on historical empirical evidence. Third, it will analyse the macro and distributional implications of adaptation-driven energy use with an economy-energy model characterising the distribution of energy use dynamics across and within countries.Given the central role of energy as multiplier for socioeconomic development and as enabling condition for climate resilience, the research proposed in ENERGYA will result in timely insights for the transition towards sustainability described by the Sustainable Development Goals adopted by the U
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Protein Binders for Characterisation of Human Proteome Function: Generation, Validation, Application', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The Affinomics programme aims to leverage existing efforts in Europe to generate large-scale resources of validated protein-binding molecules (‘binders’) as affinity reagents for characterisation of the human proteome and to apply them in comprehensive structural and functional analyses of protein expression, interactions and complexes. Proteome targets will be focused on five categories of inter-related human proteins involved in signal transduction, cell regulation and cancer, namely protein kinases, SH2 domain-containing proteins, protein tyrosine phosphatases, proteins somatically mutated in cancers and candidate cancer biomarkers. Binders to about 1000 protein targets will be made over the course of the programme. A high throughput, coordinated production pipeline for antigens and binders will be established. Target antigens will be expressed in three forms, as folded full-length proteins or domains, as large peptide fragments (PrESTs) based on low homology to other human proteins and as small peptides, in some cases phosphorylated. Binder types to be generated include affinity-purified polyclonal antibodies, monoclonal antibodies, recombinant antibody fragments and non-immunoglobulin scaffolds. An important aspect will be the development of highly efficient ‘next generation’ recombinant selection methods, based on phage, cell and ribosome display, capable of producing high quality binders at greater throughput and lower cost than hitherto. Systems and procedures for thorough binder validation and quality control will be established. The affinity reagents will be applied in advanced innovative and sensitive technologies for specific detection of target proteins and interacting protein complexes in cells, tissues and fluids, for improved understanding of protein fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modelling vegetation dynamics and degradation in Mediterranean ecosystems.' (1994-1998).

assistant: **Innovation**

The project is aimed to the better understanding of the dynamics and degradation processes of Mediterranean ecosystems, based on the premise that the prevention and reversal of desertification depends on the processes which determine vegetation structure as it is the plant cover which protects the soil from erosion and determines ecosystem function.The project will provide a completed version of a model of vegetation dynamics at a range of different spatial and temporal scales. A modular modelling approach has been used to scale up from a dynamic, time-dependent simulation of plant species behaviour to the level of the landscape thus bridging the gap between species-level and GIS-orientated models. To this aim, the ecophysiological behaviour of several dominant species of Mediterranean vegetation is under characterisation to parameterise an Individual Based Plant Community Level Model. Another version of the model will be based on a Transition Matrix approach with reference to major vegetation types. A simplified version of the simulation model will be associated with a multimedia hypertext for educational applications. This will provide information on a selected number of reference study cases of changing land use scenarios in different Mediterranean countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms of neurotransmitter uptake and storage by synaptic vesicles', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

SummaryIn presynaptic nerve endings, neurotransmitters are stored in synaptic vesicles (SVs) before they are released by exocytosis. SVs contain specific transporters that sequester and concentrate transmitters from cytoplasmic pools. All known vesicular transporters belong to the solute carrier (SLC) superfamily of proteins. They draw the energy for transport from an electrochemical proton gradient created by a V-ATPase across the vesicle membrane. However, despite recent progress it is still largely unclear how synaptic vesicles are filled with hundreds of mM transmitter within less than a minute. Open questions include (1) how exactly transport is linked to the proton gradient and which ions are coupled to solute transport, (2) how two different transmitters can be accommodated by the same SV, and (3) how much transmitter can be loaded into an SV and how the stored transmitter is kept inside and prevented from leaking out. Here we will focus on the vesicular transporters for glutamate (VGLUTs) and GABA/glycine (VGAT or VIAAT), the main excitatory and inhibitory transmitters in the CNS, and on the vesicular transporter for ATP (VNUT). Primarily we will use biochemical approaches employing purified SVs and artificial vesicles, recombinant proteins (either purified and reconstituted in liposomes or using vesicles isolated from transfected cells), in combination with quantitative in vitro assays, for characterizing the features of transport and storage. To achieve this, we plan to develop advanced methods involving adaptation of new fluorescent probes and microscopic analysis of loading and unloading using microfluidic devices. For these experiments, vesicles will be captured by affinity ligands such as antibodies printed on glass surfaces. This allows for analyzing smal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High Resolution Laser Spectroscopy of Atomic Hydrogen and Deuterium' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Discrepancies between theory and experiments have been fueling the development of physics. Today, Quantum Electrodynamics (QED) is the most accurate theory and served as a blueprint for all subsequent field theories. Physics beyond the Standard Model must exist as we know from observations of the cosmos. It is likely to be found where no one has looked before, i.e., at very large energies, high sensitivity, or high precision. To progress with the so-called precision frontier, high resolution spectroscopy of atomic hydrogen and hydrogen-like systems continues to play a decisive role because their simplicity. Testing QED means to verify the consistency of parameters that enter this theory as they are obtained from as many different measurements as possible. Spectroscopic data also provides the input for the determination of the best values for the fundamental constants. The largest leverage for the determination of the Rydberg constant is currently due to the 1S-3S transition frequency that we want to improve in the framework of this proposal. A second apparatus provides a cold metastable 2S beam of atomic hydrogen and deuterium. This will be used in a series of measurements between the 2S and nP states as well as two-photon transitions between 2S and nS/nD states (with n=3…10). The same apparatus can be used to remeasure the 1S-2S transition frequency as an improved result from anti-hydrogen is expected. The work with the spectrometers builds on proven technologies. To go further we are proposing a method to trap atomic hydrogen in an optical dipole trap that operates at the magic wavelength. The proposed scheme avoids a cooling laser and will not be more complex than existing optical lattice clocks. It could eliminate all leading systematics for the above-mentioned tran