RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Re-use of Thermoplastic Composite' under Horizon 2020.

assistant: **Concept**

Current European policies plead for new technologies capable to implement feasible processes for recycling of products in their end of life cycle. Within this framework the re-use of thermoplastic composites, is a recurrent topic within the aircraft manufacturing industry which needs a suitable solution for the high performance thermoplastic composites once the craft is dismantled. PEEK (Polyether ether ketone) and PPS (Polyphenylene sulphide) all together reinforced with CF (Carbon Fibre) and, are the most common high performance materials considered as leftovers when their lifecycle has come to an end .Taking this into account, the RESET project aims to bring a second life to those thermoplastic composites which have been condemned to landfills, to the carbon fibre recovery by means of polymer pyrolysis or to energetic recovery. This milestone will be achieved through a sorting and milling process of these materials, leading to short chopped fibre reinforced thermoplastic granulates. These conditioned leftovers will be subsequently used to obtain new reinforced thermoplastic composites, by melt compounding along with virgin polymer, considering both monocomponent as well as binary blends. Besides, an evaluation of the properties of recycled materials will be carried out in terms of repeatability, processability and final product properties in order to ensure the suitability of the products regarding the final application of the demonstrators (e.g, brackets, clips...). With that purpose, process parameters will be defined during the design and evaluation of the prototypes mould. Summing up, the RESET project will lead to a whole new family of rCFRP reducing, therefore, the environmental footprint by giving a second life to the waste, by means of recycled high value pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ruthenium Peptide Bioconjugates for Photoactivated Chemotherapy' in the context of a Horizon Europe call.

assistant: **Objectives**

One of the most severe limitations of current anticancer chemotherapy are the serious side effects caused by toxic drugs affecting not only tumors but also healthy organs. Local activation of drugs by light irradiation of the tumor is a promising approach to control where the toxicity is delivered. Metal complexes are well suited for photoactivated chemotherapy, but their activation wavelength is often too low to afford high tissue penetration of light; also, their ability to enter cancer cells is often controlled by lipophilicity tuning, which is unselective; finally, their phototoxicity often relies on oxygen-dependent mechanisms, while many tumor tissues show low dioxygen concentrations.  The aim of this proposal is to develop new metallodrugs that are activated by red or near-infrared light, enter cells by controlled mechanisms, and deliver strong phototoxicity to cancer cells also under low oxygen conditions. The design is based on connecting multiple Ru(II) metal complexes to a biologically active antitumoral peptide. The ruthenium complexes will have a tuned coordination environment to allow red/near-IR light activation; meanwhile, the peptides will rely on methionine residues to coordinate ruthenium, and allow controlled cellular uptake of the prodrug into cancer cells. Both components will cage each other in the dark, thus affording low toxicity; while light-induced cleavage of the ruthenium-thioether bonds will release two bioactive components, which will kill cancer cells.  The novelty of this proposal is to combine metal-based photoactivated chemotherapy with therapeutic peptides to enhance phototoxicity by creating synergies between both photoproducts. By combining light activation, resulting in timely- and spatially-resolved toxicity release, and bioactive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Plant evolutionary and ethnobotanical diversity changes along an altitudinal gradient'.

assistant: **Concept**

This proposal, BIODIVERSITYALTITUDE, is for a 24 months intra-European career development fellowship at the Natural History Museum of Denmark, University of Copenhagen in Denmark (host institution).In summary, this project investigates plant biodiversity and usage dynamics within plant communities using a cross-disciplinary framework spanning ecology (altitude), biodiversity (species numbers), evolution (phylogeny), and ethnobotany. Using a comprehensive generic phylogeny of the Nepalese Himalayan flora, extensive elevation distributional data of plants in the flora of Nepal, and ethnobotanical information from the literature, this study will explore changes in biodiversity, phylogenetic diversity, and plant usage along an altitudinal gradient. This project will aim to reveal patterns in biodiversity turnover along an altitudinal gradient using modern evolutionary methods. It will also investigate the dynamics of plant usage along this gradient. By shedding light on the processes that shape plant biodiversity and plant usage along ecological gradients, the results from this study will help us understand how to best protect and utilise biodiversity sustainably, which is particularly timely in the face of imminent climatic changes.Dr. Charilaos Haris Saslis-Lagoudakis has studied and worked in several institutions in Greece and the United Kingdom.  He has applied modern approaches to understand evolutionary patterns in biodiversity and ethnobotany and, at the age of 28, he has produced several publications in some of the best journals of different fields, as well as in general science journals. The additional scientific and technical skills and expertise gained during this IEF will be of great value to Dr Saslis-Lagoudakis in the next phase of his research career. He will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Decoding the molecular basis of lateral root stem cell specification in plants: C-fern as a model system.' (LAROSSE).

assistant: **Concept**

To conquer land, vascular plants evolved a sophisticated root system, which consists of primary and lateral roots (LRs). The de novo LR organogenesis represents a major evolutionary innovation, which has provided sessile organisms like plants with the capacity to forage for water and nutrients. The host lab is a pioneer in demonstrating that LR formation requires de novo specification of stem cells inside the primary root. They also discovered that the early stages of LR initiation are regulated by an oscillatory mechanism where the phytohormone auxin plays a major role. Despite these advances, the exact molecular mechanisms underlying lateral root stem cell (LRSC) specification remain largely elusive and it is not known how these mechanisms emerged during plant evolution. To address these fundamental questions, I will use an emerging model system Ceratopteris richardii (C-fern), which is an evolutionary pivotal, yet underexplored model plant. Based on fossil records, ferns and seed plants diverged during the middle Devonian period from a common ancestor suggesting that several key regulators might be conserved among them, despite some differences in their root ontogeny. In C-fern, the formation of LRSCs is clearly visible at the anatomic level. C-fern has ancestral and possibly simpler mechanisms underlying LRSC specification. In this project, I aim to identify key transcription factors controlling LRSC specification in C-fern. To achieve this goal, I will combine my expertise in molecular and developmental biology with multidisciplinary approaches including single cell RNA sequencing, CRISPR/Cas9-based genome editing and top-notch confocal imaging. This project has a strong potential to introduce novel concepts in the field of plant stem cells and their evolution. It
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'REM sleep behaviour disorder: a model to investigate motor control pathway(s) and memory consolidation during REM sleep' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

REM sleep behavior disorders (RBD) are violent dream-enactments caused by loss of normal muscle atonia during REM sleep. RBD are idiopathic or associated with neurological diseases (parkinsonism, narcolepsy) and represents an exceptional window on dream content and motor control during REM sleep. The characteristics of the movements during RBD have been poorly studied. In patients with Parkinson’s disease, we recently found that movements were faster, and speech was more intelligible during RBD than during wakefulness. The disappearance of parkinsonism during REM sleep suggests a transient ‘levodopa-like’ reestablishment of the basal ganglia loop. Alternatively, the jerky movements could be the expression of the primary motor cortex, relieved from the filtering, smoothing control of the basal ganglia. To support this hypothesis, using questionnaire and video-polysomnography, we will measure (i) if the head, mouth, arms and hands are more used than the legs during the RBD, as they have a larger cortical representation ii) examine the synchronization between the direction of eye movement (the major characteristics of REM sleep) with other movements during RBD in relation to dream imagery in REM sleep. To further understand the role of REM sleep-dependent procedural learning, we will also analyze in RBD patients if a specific procedural task is replayed during REM and the context of the replay. The first, precise description of movements during RBD and their synchronization with rapid eye movement real-time correlated with visual dream imagery would bring important information to recognize them in complex clinical cases, to infer their source, and to understand why parkinsonism disappears during RBD. Finally, the exploration « in live » of the potential replay of a procedu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European GNSS-R Environmental Monitoring' (E-GEM).

assistant: **Concept**

The E-GEM project proposes to evolve the current status of GNSS Reflectometry (GNSS-R) methods for the purpose of Earth monitoring, paving the way for operational applications in the domains of ocean altimetry and scaterometry (mainly wave height and surface winds, but also soil moisture, and biomass, monitoring of ice layers). The approach of the E-GEM project is to bring together lead experts in GNSS-R technologies and experienced teams in Earth Observation domains, in order to address the data needs and requirements of GMES services and other Earth monitoring initiatives, and how can GNSS-R methods best respond to the identified challenges in these domains. A strong connection with the users basis as well as with institutional, public and private stakeholders interested in the development and usage of the technology, will also steer the project’s efforts, and increase the awareness of this promising technology.  Within the E-GEM project, three experimental platforms will be developed for GNSS-R data acquisition: a space-borne, an airborne and a ground instrument will acquire large amounts of data to support the development of algorithms. This data, together with the large effort put on the development and validation of algorithms and processing chains, will aim at obtaining high-resolution products for altimetry, wave height and surface winds. The expected improvements should largely result from the usage of the GPS P code (with the space- and airborne acquired signal), and Galileo’s AltBOC signals. For these purposes, the E-GEM project will rely strongly on the achievements of the GNSS-R community so far - in which European teams have historically had a leading role so far - and will bring together the individual efforts and other on-going projects into a joint work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Inference in High Dimensions: Light-speed Algorithms and Information Limits' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Extracting information from data is the key challenge of our time, and in many applications (e.g., genome-wide association studies, data compression, and virtual assistants such as ChatGPT) both the data and the machine learning model used to extract information are increasingly high-dimensional. As traditional statistical theory is ill-equipped to face this explosion in the dimensionality of the problem, machine learning is now predominantly experimental. However, empirical approaches come with huge costs affordable only to large companies, and they lack interpretability, which is especially troublesome in medical applications.  To address these issues, the INF^2 project develops information-theoretically principled methods for high-dimensional inference in machine learning and data science. The key insight is that, via a “mean-field” approach, high-dimensional quantities are well approximated by low-dimensional ones and then characterized exactly. Leveraging this characterization, we will (i) establish the fundamental limits of inference, i.e., the minimal amount of data necessary to solve the problem, and (ii) design efficient algorithms requiring only the minimal amount of data. The challenge we tackle is to apply this paradigm to practical settings, in which data are structured and heterogeneous (as in genome-wide association studies), and models consist of complex architectures tailored to applications (auto-encoders for data compression, and transformers for ChatGPT).   Through a novel analysis of spectral methods, approximate message passing and gradient descent, INF^2 builds a theoretical framework having conceptual impact, as well as vast applicability, in machine learning and information theory. This framework is then brought to the real world via application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'OntoWiki – Semantic Collaboration for Enterprise Knowledge Management, E-Learning and E-Tourism' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of this project is to prepare and start-up the commercial exploitation of the semantic collaboration software OntoWiki in the three different target markets, namely Enterprise Knowledge Management, semantically enhanced content management for E-Learning and E-Tourism. OntoWiki is a comprehensive open-source platform for social semantic collaboration. It is developed at Universität Leipzig and has a large and active user base. Within the course of the project OntoWiki will be further developed and adopted to the needs of the SME for exploitation of OntoWiki in the prospective target markets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MAmmary chemoresistant Tumor deAth by Directed cell ORientation' to be submitted under Horizon 2020.

assistant: **Abstract**

Breast cancer is the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012. Fortunately, the availability of diagnosis tools to detect mammary neoplastic tissues, as well as transcriptomic biomarkers helping for prognosis, and the diversity of treatment options for primary tumors allows a 90% 5-year survival rate. However the metastatic grade of breast cancer is still not curable.Advances from basic research in the last decade outline the epithelial-to-mesenchymal transition (EMT) as a key program of molecular events triggering metastatic dissemination [Nieto MA, Cell, 2016]. Impairing the EMT process appears as a very seductive way to cure breast carcinoma cancer. Based on preliminary results obtained from “SPICY” ERC Frontier Research Starting Grant, in which we successfully develop an assay dedicated to characterize the EMT state of breast carcinoma cells [Thery M, EP 2180042 A1, 2008 ; Burute M, Dev. Cell, 2016], MATADOR is an ERC proof-of-concept project which proposes a genuine innovative strategy to develop marketable cell based assays allowing the discovery of new drugs efficiently curing mammary tumors, and create a CRO-type biotechnology company exploiting the pre-existing and newly created intellectual property: including marketable assays and therapeutics defined in MATADOR.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The I in Misinformation: Understanding the Role of Individual Behavior in Social Media Information Diffusion' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The diffusion of misinformation, propaganda, and conspiracy theories on social media are threating democratic values worldwide. Malevolent use of social media is not only eroding public trust in mainstream media but is also reducing citizens’ trust in democratic institutions. This decline in trust (and often in concert with unfounded claims) has led to protests and even violent rioting, illustrating a growing divide between citizens and their democratic institutions. Although several interdisciplinary solutions have been developed to gauge and control the cascade of misleading information, the threat persists and is only predicted to deteriorate. Previous research has pointed out that, thus far, little attention has been paid to the individuals’ behaviours when consuming news. In this interdisciplinary work, we set out to harness insights from emerging paradigms in cognitive science, social psychology, collective behaviour and computational social science to better understand the sociological, cultural, and psychological factors that influence individuals’ choices when consuming and sharing misinformation; and how these choices cascade throughout their social circles and communities. The project aims to gain insights into individuals’ online behaviour on three key dimensions, 1) visual attention, 2) conversational affordances, and 3) temporal information diffusion. By combining these insights with computational social science and statistical methods, and by applying them to large-scale digital trace data of EU citizens, we aim to provide new insights into the sociological and psychological factors that make individuals more susceptible to trusting misinformation. The project aims to contribute to the EU’s democracy plan of developing policies to defend EU citizens again
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design of a pan-European Infrastructure for Large Apparatus studying Grand Unification, Neutrino Astrophysics and Long Baseline Neutrino Oscillations' to be submitted under Seventh Framework.

assistant: **Abstract**

Key questions in physics can be answered only by constructing a giant underground observatory to search for rare events and study terrestrial and astrophysical neutrinos.  The Astroparticle Roadmap of ApPEC/ASPERA strongly supports this, recommending that: “a new large European infrastructure of 100'000-500'000 ton for proton decay and low-energy neutrinos be evaluated as a common design study together with the underground infrastructure and eventual detection of accelerator neutrino beams”.  The latest CERN roadmap also states: “a range of very important non-accelerator experiments takes place at the overlap of particle and astroparticle physics exploring otherwise inaccessible phenomena; Council will seek with ApPEC a coordinated strategy in these areas of mutual interest.”Reacting to this, uniting scientists across Europe with industrial support to produce a very strong collaboration, the LAGUNA FP7 design study has had a very positive effect.  It enabled, via study of seven pre-selected locations (Finland, France, Italy, Poland, Romania, Spain and UK), a detailed geo-technical assessment of the giant underground cavern needed, concluding finally that no geo-technical show-stoppers to cavern construction exist.  Building on this, the present design study will address two challenges vital to making a final detector and site choice: (i) to determine the full cost of construction underground, commissioning and long-term operation of the infrastructure, and (ii) to determine the full impact of including long baseline neutrino physics with beams from CERN.