RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Planning, Urban Management and Heritage' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project will develop a joint networking and advanced research programme on critical issues of planning, management and urban heritage that will strengthen research partnerships between European and Chinese partners. This aim will be achieved by short and longer-term periods of staff exchanges and networking activities between the participants, each a prestigious research institution. In total 79 researchers will undertake 215 months of exchange.The ultimate goal of this project is to achieve more rapid progress in advancing current knowledge, both conceptually and in terms of practical strategies of management, of the challenges of managing heritage as part of a wider process of spatial planning in the very different contexts provided by Europe and China. Its focus is the role of heritage in continuity and change in the city and region. Urban areas are the critical sphere of investigation as it is cities and urban regions that are subject to the greatest pressures for change and transformation and conflict and potential complementarity with heritage protection most acute. Europe and China are, broadly speaking, polar examples of the rate of urban change. In Europe the pace of urban change, in part due to heritage designation, is often very slow and we maybe building up a “heritage time-bomb”. In China, by contrast, urban change is an astonishingly rapid process, with the risk of heritage erasure. Each of the participating organisations has expertise in these areas and each is a geographical location that presents rich empirical case studies to explore.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Towards a European larch wood chain'.

assistant: **Objectives**

Larch (Larix sp.) Is a potentially important timber species throughout Europe increasing the environmental and amenity value of our forests. It is one of the fastest growing conifers with valuable wood properties, well suited for afforestation of surplus agricultural lands, diversification of conifer monocultures and enrichment of existing forests. Nevertheless its role in Europe is still too minor compared to booming exotics such as Douglas-fir or Sitka spruce. One of the major reasons seems to lie in the absence of a true commercial market for the new lowland timber resource, due to the mutual ignorance of industrials on one side (traditionally located in the native range) and forest owners (in lowlands) on the other. Questions about wood quality of this new resource is unavoidable and it seems even the key to create a better context for developing an active commercial market. A second reason, often invoked by foresters, lies in the scarcity of improved larch material for reforestation and the nearly absence of silvicultural guidelines for establishment and management of stands. Wood industrials, wood technologists, silviculturists, breeders and plant propagators are invited in this project to work together and develop a research larch wood chain. It is a challenge as competence is scattered across Europe but expertise exists both at the industrial, technical and scientific levels to answer to the 2 major concerns summarized above. Four research and development tasks have been considered: - The first one 'Wood technology', tackled both at the industrial and laboratory levels, will focus on the following questions: i) How does the quality of lowland larch wood compare to that of the famous alpine larch wood ? Ii) What is the impact of genetics and environment on natura
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Role of Lipolysis in the Pathogenesis of Cancer-associated Cachexia' under Seventh Framework.

assistant: **Concept**

Cachexia is a complex syndrome characterized by massive loss of body weight due to uncontrolled loss of adipose tissue and skeletal muscle. The wasting occurs during late stages of many unrelated chronic diseases and frequently leads to the death of affected individuals. Cachexia is most common in cancer, where an estimated 25% of patients die from cancer-associated cachexia (CAC) rather than from the cancer. Despite the tremendous impact of CAC on morbidity and mortality, the underlying molecular mechanisms are poorly understood.Recently, we demonstrated that lipase-catalyzed triacylglycerol (TG) catabolism is required for the pathogenesis of CAC. Mice lacking adipose triglyceride lipase, the rate-limiting enzyme for TG hydrolysis (lipolysis), were completely protected from loss of both adipose tissue and muscle in two forms of cancer. This implies an essential role of the lipolytic process in the pathogenesis of CAC. Here we propose to elucidate the causal role of lipases and their coregulators in CAC development. We will determine mechanisms involved and pursue novel treatment strategies.Our objectives are to:- Investigate how different cancers in mice regulate tissue-specific lipolysis;- Elucidate the functional role of lipases and their coregulators in the pathogenesis of CAC;- Assess whether pharmacological inhibition of specific lipases prevents or delays CAC;- Study the effects of cancer-induced lipolysis on energy dissipating pathways and epigenetic control.The project enters a largely unexplored field: the role of lipid metabolism in the pathogenesis of CAC. The work will heavily rely on the characterization of induced mutant mouse models with CAC and require extensive collaboration with experts in pathology and large-scale systems analytics. The results are e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stimulating, Encouraging and Facilitating the Participation of ACC Nanotechnology and Nanoscience Research Organisations To FP6' will create measurable scientific, societal and economic impact aligned with FP6.

assistant: **Impact**

The STEF-NANO-ACC project proposes a coherent action plan for increasing participation of Associated Candidate Countries in NMP priority of FP6. The activities planned will also contribute to the creation of ERA by facilitating ACC research potential wider cooperation within FP6 initiatives as well as other ways of cooperation between ACC themselves as well as Member States and third countries. The plan of STEF-NANO-ACC will also renew enthusiasm in science and research for NMP all over Europe. The core of the project is WP1 which relates to organisation of conferences, workshops and brokerage events in Poland and Hungary. Part of WP1 activities relating to conference in Poland will be combined with the INDUSTRYLINK project. The identification of young research potential in NMP aiming among other things to renew enthusiasm in Europe will be carried out in WP2. Identified outstanding young researchers (women will be more preferable) will take part in different activities of envisaged in the project. All activities will be coordinated according to WP3 being in charge for the high quality of deliverables of the whole project. The European R&D associations for NMP are associated to the project on the basis that they or their members will be invited to strategic activities of the project (like brokerage events) as well as will be informed about the deliverables of the project. The project will cooperate with the European network of NCPs mainly from MS to improve the capacities of researchers of ACC and to facilitate cooperation between ACC partners and MS partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative manufacturing processes and in-line monitoring techniques for the OLED and thin film and organic photovoltaic industries (CIGS and OPV)' under Horizon 2020.

assistant: **Concept**

Opto-electronic devices are opening exciting new applications everyday. With new display options using pliable substrates such as plastic and flexible glass, OLEDs manufacturers are bringing a wide range of new applications in lighting (e.g. energy efficient lighting) and different type of displays. Similarly, with the emergence of thin-film technologies in the solar cells market, new applications ranging from installations on curved surfaces to building-integrated PV has become possible. However, to meet the industry requirements for mass production, including low cost, manufacturing volumes and efficiency, many challenges still need to be addressed. These challenges for OPV, OLED and CIGs are scale-up from laboratory to mass production, selection of efficient manufacturing processes, employing inspection, control and measurement techniques to improve yield, quality and time-to-market. OLEDSOLAR aims to tackle these challenges by developinginnovative manufacturing processes for critical steps in the production of opto-electronic devices including OLEDs, OPVs and CIGs solar cells. The proposed activities include reconfigurable high yield (>10% improvement) processes to be scaled up, tested at pilot lines and implemented in production line for validation. A complete system of inspection, quality control, functional testing and measurements using advance system and sensors will be optimised in the project for efficient manufacturing of opto-electronics parts. Recycling and re-use strategies will be developed allowing resource efficiency and reduction of high value product wastes. Automation and advance processing software will be developed for overall control and monitoring of roll-to-roll (R2R) and sheet-to-sheet (S2S) manufacturing process.During 36 months, a multidisci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development and evaluation of Leydig cell lines as in-vitro models for toxicological testing' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The aims of this project are to develop and evaluate tests for toxicological insults to Leydig cells, in particular those leading to changes in steroid hormone formation, cytotoxicity and hyperplasia. This will be achieved by the development and use of (1) Leydig and Sertoli cell lines from transgenic mice carrying a temperature-sensitive T-antigen and (2) established tumour Leydig cell lines. Co-cultures and comparison of these cells with primary Leydig and Sertoli cells and macrophages will be studied in order to develop in-vitro Leydig cell models suitable for toxicity testing. Leydig cells are the main source of the male androgen, testosterone, which plays an essential role in controlling spermatogenesis. In view of the wide range of pharmaceutical compounds reported as Leydig cell toxicants (1) and the recent discovery of the deterioration in human male reproductive health (viz falling sperm count and associated reproductive disorders)(2), there is an urgent need for developing Leydig cell toxicity tests. Also, because in-vivo toxicity studies are over a 1-2. year period, it is desirable to have acute in-vitro methods which would detect early changes in Leydig cell function. Identification of targets and mechanisms of Leydig cell toxicity will allow the development of specific end points such as cytotoxicity, inhibition or overstimulation of steroidogenesis, specific proteins involved in the control of steroidogenesis, transcription factors, adhesion molecule expression as a marker of abnormal cellular interactions and tissue development, and hyperplasia. Transgenic mice will be developed and Leydig cell lines (with constitutively active luteinising hormone (LH) receptors) and Sertoli cell lines (lacking anti-mullerian hormone (AMH)) will be produced from such mice
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'FUture European League 4 Microalgal Energy' (FUEL4ME), addressing dissemination and exploitation.

assistant: **Impact**

Microalgae are very attractive for the purpose of producing energy-rich molecules as they are photosynthetic organisms that can live in various aqueous environments, such as saline water. This gives them a low water footprint and moreover they do not have to compete with cultivated farmland. Although they are not superior to higher plants concerning photosynthetic efficiency, microalgae do have high growth rates and they provide much higher oil yields than higher plants such as palm, soybean or rapeseed, and do not produce lignocelluloses. Microalgae do not only use sunlight as energy source, but they are also very efficient in using fertilizers and waste streams as nutrient source. They could be used to clean these streams by removal of nitrogen and phosphate and use flue gas as source for carbon dioxide.The potential of microalgae is clear but the technology for producing biofuels from microalgae is still immature. In order to make microalgae as a source for biofuels competitive with fossil fuels, it is important to reduce operational costs and to achieve a positive energy balance (fossil energy input is higher than energy output). The overall aim of FUEL4ME is to establish a sustainable chain for continuous biofuel production using microalgae as a production platform, thereby making 2nd generation biofuels competitive alternatives to fossil fuels. This will be achieved by:1) Transforming the current 2-step process for algal biomass production into a continuous 1-step process with high lipid content (production process);2) Development of a continuous downstream process using all components of the algal biomass (conversion process);3) Integration of production and conversion process.After setting up and proof of concept within controlled indoor conditions, the continuo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'BlueMissionBANOS – supporting the Mission Ocean Lighthouse in the Baltic and North Sea basins' under Horizon Europe.

assistant: **Concept**

The EU-Mission ‘Restore our Ocean, Seas and Waters by 2030’ is a new EU wide broad mobilization initiative, expected to bring concrete solutions to protect its ecosystems and biodiversity, prevent and eliminate pollution and turning the blue economy both carbon-neutral and circular. Substantial resources are made available to establish lighthouse projects, BlueParks and improved digital knowledge systems. These need to be matched with corresponding efforts by all stakeholders at national and regional scale. BlueMissionBANOS, BMB, has the ambition to act as an efficient facilitator and knowledge broker as to inspire, engage, and support stakeholders from politics, industry, science and the public across the BANOS area to channel resources effectively towards the Mission Ocean objectives. The BMB consortium gathers some of the most active research institutes, networks/clusters and funding agencies from the Baltic and North Sea sea-basin. Capitalizing on their past and ongoing activities, BMB partners will work with existing governance structures from regional up to transnational level within the BANOS area to design an effective, transparent, mutually-reinforcing interplay between them (WP2); support citizen engagement initiatives to align with the Mission’s objectives (WP3); accelerate the deployment of solutions through five innovation and demonstration cycles (WP4); develop a consistent monitoring framework to assess Mission performance including definition of baselines; key performance indicators and sources/methods to capture and analyse the relevant data (WP5); supported by a digital, interactive portal showcasing projects and services relevant to Mission deployment (WP6). To maximize effectiveness of available public and private funding opportunities and achieve cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Scattered radiation reduction tool to improve computer-aided diagnosis performance in digital breast tomosynthesis'.

assistant: **Concept**

Breast cancer is the most common cancer diagnosed in women worldwide. This has motivated the establishment of breast screening (BSPs). X-ray mammography is the current gold standard technique in BSPs for early breast cancer detection. However, this technique suffers from performance limitations due to tissue superposition which can either mimic or obscure malignant pathology. For this reason digital breast tomosynthesis (DBT) is currently being investigated.DBT consists of a series of projected images of the breast with potential to overcome the aforementioned limitations. However, DBT shows high levels of scattered radiation within the image receptor which can reduce significantly the visibility of breast lesions and the lesion detection performance of computer-aided diagnosis (CAD) systems. CAD systems are frequently used in BSPs to provide useful information to radiologist regarding breast lesion location and characterisation, thus CAD’s performance is critical to achieve acceptable breast cancer diagnosis rates. The aim of this fellowship is to develop a novel tool to reduce scattered radiation directly from clinically acquired DBT projections. These scatter-reduced images will be incorporated, for the first time, into a new DBT CAD system to significantly improve the detection of subtle lesions as microcalcification clusters (MCC). The scatter reduction will be achieved after adapting an existing convolution-based algorithm for synthetic DTB images to work with clinically acquired DBT images. The CAD experience of ViCOROB and the DBT experts’ support from UDIAT guarantee the success of this project as well as the correct transfer of knowledge from the lab to the clinical site. The proposed tool will enable radiologists to detect more accurately breast lesions and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural and functional characterization of different states of the arginine vasopressin V2 receptor' to be submitted under Horizon Europe.

assistant: **Abstract**

G protein-coupled receptors (GPCR) are the largest superfamily of cell surface signaling membrane proteins and the targets of 30% of marketed drugs for many human diseases. They respond to diverse extracellular stimuli by transmitting the signal across the membrane and activating a number of intracellular signaling pathways. To sense these stimuli and couple to signaling partners such as G proteins, these transmembrane domains have a high conformational flexibility, representing a challenge for structure determination. Both improvements of GPCR expression and purification, and the cryo-EM revolution have led to structurally characterized GPCR to better understand these signaling key players. However, defining active states of a given receptor is still a difficult challenge that led to success only for a dozen different GPCR. This project focus on the characterization of different states of the arginine vasopressin (AVP) V2 receptor (V2R). The V2R is considered as a receptor model for small peptides and hormones and is a crucial therapeutic target. The atomic resolution data will contribute to a better knowledge of the V2R transmembrane signaling. The comparison of the different active states of the V2R to the inactive state of V2R will provide key information for deciphering the molecular events leading to receptor activation. Then, blocking the V2R with antagonists is a validated therapeutic avenue for two unmet medical needs, hyponatremia and autosomal dominant polycystic kidney disease. V2R interacts not only with Gs protein but also with arrestins, the development of biased agonists that selectively activate or inhibit one signaling cascade among all triggered by the natural hormone is also a very promising therapeutic line. Keeping in mind the interest of antagonis