RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Brownian Motor Based Virus Detection' (MoViD) targeting Horizon 2020.

assistant: **Abstract**

The detection of dilute populations of nanoparticles in microfluidics is difficult due to diffusion as the time limiting step to reach the sensor. Using active transport, we propose to build a proof of concept microfluidic device that reaches sub-attomolar detection sensitivity within an hour and at a device footprint of 1 cm. The active transport enables size separation of the particles into multiple channels and up-concentration in detection reservoirs for label free detection. At the end of the process the size-separated particles can be easily extracted for further downstream processing.The applied use case is the detection and quantification of virus in drinking water, a global health-critical challenge. A viral concentration of 10-100 particles is infectious in 2l of water consumed by a person, corresponding to a concentration of 10^(-22) molar. Traditional methods rely on multiple concentration steps followed by detection using molecular and/or culture based methods. Most common are adsorption/elution assays which co-concentrate and add contaminations that interfere with the downstream detection analysis. The detection methods are also often specific for the viral type and require a priori identification of the target virus. Metagenomic sequencing allows for general identification but lacks sensitivity. The proposed method will simplify and improve the process significantly. The viruses will be concentrated without damage of the virus shell and with a high rejection of the contamination present in the sample. All virus particles will be separated and sorted according to predefined size ranges into detection compartments on the chip, allowing for a parallel and quantitative marker-less detection on a single particle level. Specific identification is possible for f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Green Aquaculture Intensification in Europe' (GAIN) under Horizon 2020.

assistant: **Objectives**

GAIN is designed to support the ecological intensification of aquaculture in the European Union (EU) and the European Economic Area (EEA), with the dual objectives of increasing production and competitiveness of the industry, while ensuring sustainability and compliance with EU regulations on food safety and environment. Eco-intensification of European aquaculture is a transdisciplinary challenge that requires the integration of scientific and technical innovations, new policies and economic instruments, as well as the mitigation of social constraints. Successful eco-intensification of aquaculture will provide more and better aquatic products, more jobs, and improve trade balance by reducing imports. GAIN, besides looking at innovative ways of integrating cultured species, will seek integration with other sectors, in order to promote the implementation of the principles of circular economy in Aquaculture. The GAIN Consortium includes a wide range of complementary expertise and a well blended mix of research institutes and industrial partners, which will ensure the achievement of the following specific objectives:(i) Develop and optimize sustainable feeds, without increasing the pressure on land and fish stocks;(ii) Add value to cultivation, by means of innovative processes, which turn both by-products and side-streams into valuable secondary materials, thus increasing profits and minimizing the environmental footprint;(ii) Improve the management of finfish and shellfish farms, in terms of FCR, fish welfare and reduction of wastes, through the use of sensors, biomarkers, Big Data, IoT (Internet of Things) and predictive mathematical models;(iv) Support integrated policies and address current barriers to the implementation of the principles of circular economy in aquatic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gamma delta cells and immunosurveillance' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Epithelia are potentially vulnerable to infection and environmentally induced mutation. Although there unwell-established ideas for how the immune system may protect epithelia, they fail to mention intraepithelialymphocytes (ells) that are one of the largest T cell compartments. Gamma delta cells contribute to a large part to these ells. The properties of gamma delta cells seem to place them midway the adaptive and innate immune response. The host laboratory has recently obtained evidence that gamma delta ells provide bothimmunoprotection and immunoregulation within epithelia: this proposal asks how. There are two aims: in the first, candidate genes will be identified by comparative Serial Analysis of Gene Expression (SAGE); in the second the contribution of particular genes to IEL activities in vitro and in vivo will be examined (e.g. by RNA interference).The results should provide a much-improved understanding of epithelial immunosurveillance.The experience profile of David Vermilion (e.g. NK cell background, experiences with ransoms, confocalmicroscopy and apoptosis assays) can clearly add value to the applied project. Equally clear are the benefits for David Vermilion to be gained from his participation in the proposed project Gamma delta cells andimmunosurveillance. He will be trained in advanced techniques like SAGE, he will learn to work with knockout animal models and he will acquire the RNA interference technique. Thus the experience of David Vermilion on the one hand and the training possibilities offered at the Laboratory of Adrian Heyday on the other hand, are complementary. This will result in a synergistic effect and therefore enhance the scientific excellence of the European Union.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Driving up Reliability and Efficiency of Additive Manufacturing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The aim of DREAM is to significantly improve the performances of laser Powder Bed Fusion (PBF) of titanium, aluminium and steel components in terms of speed, costs, material use and reliability, also using a LCA/LCC approach, whilst producing work pieces with controlled and significantly increased fatigue life, as well with higher strength-to-weight ratios.DREAM targets the development of a competitive supply chain to increase the productivity of laser-based AM and to bring it a significant step further towards larger scale industrial manufacturing.In order to upscale the results and to reach an industrial relevant level of productivity, the project is focused on the following four main challenges (i) Part modeling and topology optimization(ii) Raw material optimization to avoid powder contamination (iii) Process optimization, including innovations of the control software of the AM machine, to enable high throughput production(iv) Setup of laser-PBF of nanostructured Titanium alloys with unchanged granulometric dimension for an additional push to higher productivity, since nanostructured metal powders can be sintered with lower energy input and faster speed.The project, thanks to the three end-users involved, is focused on components for prosthetic, automotive and moulding applications to optimize the procedure for three different materials, respectively titanium, aluminium and steel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advancing Research and Cooperation Capacities of IHM NASU towards ERA' under Seventh Framework.

assistant: **Concept**

The ERAIHM project is designed to reinforce the cooperation capacities of one of the leading research centres of Ukraine - Institute of Hydromechanics of the National Academy of Sciences of Ukraine (IHM NASU) and enhancing its part participation in European Framework Programmes.IHM NASU was founded in 1926 and is currently the largest center for research of a wide range of problems in modern fluid mechanics. IHM has a developed infrastructure of experimental tools, which is recognized as Ukrainian national heritage. Based on results of basic research IHM performs vide range of applied investigations in the areas included in such thematic priorities of Fp7 as energy, environment, transport and biotechnology.The overall project objectives are:-To develop a strategy of IHM NASU aimed at ensuring coherence of its RTD activities with socio-economic needs of Ukraine, enhancing its cooperation with European Research Centres and participation in European Framework Programmes.-To develop and implement training modules at IHM NASU to build capacity in participation in Fp7 and to facilitate involvement of stakeholders in innovation process.-To develop a Communication and dissemination toolkit for improvement of IHM visibility for Ukrainian and European research centres and stakeholders, networking, dissemination and exchange of scientific information and design of joint RTD activities.The project consortium consists of IHM NASU, the Royal Institute of Technology (KTH, Sweden) and Delft University of Technology (TU Delft, The Netherlands). The EU partners will assist IHM in capacity building activities and application of tools and methods for assessment of its innovation potential and competitive advantage. They will also support networking with research centres in EU for scientifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structure determination of amyloid oligomers, the pathogenic species in Alzheimer ́s disease using fast MAS NMR and microfluidics' (Oligomers-MAS-NMR) under Horizon 2020.

assistant: **Objectives**

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder responsible for about 2 million deaths per year. Despite tremendous progress in basic research within the last years, its efficient treatment and diagnostic tools are still lacking. The previous studies have gathered sufficient evidence of a causative role of the aggregates of two proteins - amyloid beta and tau - in the AD pathogenesis. Both of these proteins can form highly toxic oligomeric species, which are the primary suspects of AD-related neurotoxicity. However, due to experimental difficulties the detailed structural and functional characterization of the oligomeric forms has been a big challenge. In the proposed project we aim to build on cutting-edge technologies and novel approaches to obtain atomic-level structures and investigate interactions of the amyloid beta and tau oligomers. Thus, this multidisciplinary project will apply (I) cell-free protein expression and purification protocols for incorporation of various selectively 13C, 15N and 19F labeled amino-acids; (II) microfluidics in order to generate size-controlled oligomers (III) solid-state NMR (ssNMR) at fast magic-angle spinning (MAS) regime tailored for 1H and 19F detection schemes. The anticipated outcome of this will be a unique combination of approaches to study amyloid aggregates, which can be further used and adapted for studying other protein assemblies. The project results will form the basis of innovation in the treatment of AD as well as other tauopathies.


**Keywords:** Solid-state NMR, fast magic-angle-spinning, amyloids, cell-free expression, microfluidics, protein structure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Neutron Electric Dipole Moment: pushing the precision to understand the matter-antimatter asymmetry' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The existence of a permanent electric dipole moment (EDM) of the neutron, or any subatomic particle, would have far reaching implications connecting particle physics with cosmology. Time reversal invariance and CP symmetry would be violated. A new fundamental interaction producing the EDM, that is, deforming the charge distribution inside the neutron, could also have generated the matter-antimatter asymmetry in the early Universe. After 60 years of evolution, techniques to measure the neutron EDM are now so evolved that experiments are sensitive to microphysics associated with an energy scale beyond that accessible at the LHC. This situation offers a high likelihood of discovery for the next generation of experiments. In the same time, any improvement in precision is technically challenging. The control of the magnetic field must surpass that of the state of the art of atomic magnetometers. The n2EDM project aims at improving the precision by an order of magnitude or more. Systematic effects need to be controlled at an unprecedented level. In particular, the use of a mercury co-magnetometer based on the precession of 199Hg spins induces a set of subtle false effects due to the relativistic motional field. I propose to initiate a comprehensive program to master these systematic effects beyond the current research program. In particular, the proposed project includes a precise determination of the 199Hg magnetic moment with a precision of 0.1 ppm. To this end, I will attempt a novel approach: combining mercury and 4He magnetometry in the same cell. As a by-product, this will also produce an improved determination of the neutron magnetic moment, a quantity of interest for metrology. The cross-check I propose will prove that all disturbances on the neutron or mercury spins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel Air Vehicles Configurations: From Fluttering Wings to Morphing Flight' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of the NOVEMOR (NOvel Air VEhicle Configurations: From Fluttering Wings to MORphing Flight) research project is to investigate novel air vehicle configurations with new lifting concepts and morphing wing solutions to enable cost-effective air transportation. A multidisciplinary analysis and design optimization environment developed in an earlier EU Project (SIMSAC) will be used and improved to include analysis of novel configurations such as the joined-wing concept for improved lift and morphing wing solutions as an integral part of the aircraft conceptual design, rather than just as an add-on later in the design cycle. Such concepts will enable improved aircraft efficiencies, aerodynamic performance, reduced structural loads and lighter weight.The NOVEMOR project will focus on the following primary objectives:1.Design and evaluation of a new aircraft concept, the joined-wing configuration, including structural, aerodynamic and aeroelastic simulations and analysis, flight testing of an aeroelastically scaled remotely piloted vehicle and multidisciplinary design optimization techniques. This configuration will be evaluated against a conventional reference aircraft.2.Morphing wing solutions (span and camber strategies and wing-tip devices) will be proposed to enhance lift capabilities and manoeuvering. These will be considered early in the design process, right from the beginning of aircraft design cycle, included in the conceptual design.3.Design, testing and evaluation of several adaptive/morphing concepts and mechanisms as part of a conceptual design environment, capable of augmenting performance characteristics in terms of drag reduction, loads reduction, weight and noise impact reduction;4.To evaluate the overall benefits of these new concepts in terms of imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Drug detection for personal protection' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Problem: Drug rape, and related crimes, performed after a victim has been intoxicated by a drug that has been added tothe victims drink, is a growing problem and threat to EU citizens. It is estimated that app. 103.000 incidents occur annually inEU. Also the number of cases is increasing every year as the use of “drink spiking” to facilitate crimes is increasing inpopularity.The Solution: D-management has developed a device, DrugStop, which is capable of detecting if drugs have been added toa drink. We have achieved this goal by combining advanced spectroscopic techniques with advanced data processing. Bycommercialization of this device we give people, and establishment owners, a reliable and efficient way they can defendthemselves against this increasing threat.The Market: Market surveys have indicated that both individuals and owners of establishments are interested in a device thatcan detect if drugs are present in drinks. It is estimated that the total cost, in EU alone is 2.83 bill. € annually. We haveidentified an urgent need for a device that can prevent these kinds of crimes. Our device is marketed towards two classes ofend-users, establishment (bars, pubs etc) owners and the individual user. For both markets there is currently no seriouscompetitors that can offer the same kind of reliable and fast detection system as is the case for our device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Life Style and Genetic Factors in Prevention of Type 2 Diabetes'.

assistant: **Objectives**

The incoming phase will be used for orientation about the experience gained in how to prevent type 2 Diabetes (T2D) by using life style changes (reduced weight gain, increased physical activity, less dietary fat, increased fibre intake) and also through genetic prediction. A long intervention program will be designed to start the implementation in Egypt during the re-integration phase with coordination with the implementing institutions. The curriculum of training the staff on different methodology from different specialities and Health Education material for Diabetic patients to change their life style will be prepared. Genetic prediction will be considered to identify individuals at risk of developing T2D. Some risk factors (elevated plasma glucose conc. in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle) are potentially reversible. Modifying these factors with a lifestyle-intervention program would prevent diabetes. In this program, middle-aged, overweight subjects are randomly assigned with impaired glucose tolerance to either the intervention group or the control group. Each subject in the intervention group receive individualized counselling aimed at reducing weight, total intake of fat, and intake of saturated fat and increasing intake of fibre and physical activity. The average age will be 50 years, and the mean body-mass index will be measured. An oral glucose-tolerance test will be performed annually; the diagnosis of diabetes is confirmed by a second test. The mean duration of follow-up is 2-3 years. The outcome of the incoming phase will be a Plan to implement Diabetes Prevention Program in Egypt with simplified curriculum and health education materials. In the re-integration period, there will be a start of implementa