RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of Coordination Mechanisms During Different Kinds of Emergencies' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The threat of mass casualty incidents or medical surges to healthcare systems has always been present. Preparing essential parts of the healthcare system such as hospitals and their partners to prevent, respond, and rapidly recover from these threats is critical for protecting and securing the entire health infrastructure. Large-scale disaster situations causing mass casualty incidents are characterised by large numbers of same-type injuries which require immediate and simultaneous medical intervention and means of support such as ambulances, surgeries, specialists, diagnostic equipment and others.These characteristics underline the need for enhanced communication between medical institutions and other organisations involved in disaster management. At the same time, the surge of demand for services to patients points to the need for better organisation within hospitals concerning the deployment of specialists and the availability of medical supplies, transportation, rooms and equipment.While a variety of incidents may necessitate an emergency response, different types of such incidents (natural disasters, explosions, humanitarian crises and others) mean a different framework for responders. While health responders are ubiquitous in their involvement with the response to an emergency situation, the parameters regarding how they are involved greatly differ with the type of threat represented.The COncORDE project will develop a Decision Support System (DSS) to improve preparedness and interoperability of medical services during an emergency which affects the health of the population at local, regional or cross-border level. The project will incorporate existing operational assets related to security, trust and infrastructure and leverage them within the DSS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Vaccine Against Schistosomiasis for Africa. A Phase I clinical study of the SchistoShield® anti-schistosomiasis vaccine in adults in endemic areas of sub-Saharan Africa'.

assistant: **Innovation**

Schistosomiasis is a poverty-related neglected tropical disease, impacting one billion people in 74 countries. Science ranked a schistosomiasis-vaccine as one of the top-10 vaccines urgently needed. Chemotherapy is the preferred method for schistosomiasis control; but the effectiveness of mass-treatment programs is compromised by reinfection requiring regular re-treatment. An efficacious vaccine, with long-lasting protection against all schistosomiasis forms, would impact disease control. We request funding for the clinical development of our SchistoShield®-vaccine (Sm- p80 antigen+GLA-SE adjuvant) in Burkina Faso and Madagascar, where Schistosoma mansoni (causing intestinal/ hepatic schistosomiasis) and S. haematobium (causing urinary schistosomiasis) are endemic. In baboon studies, SchistoShield® has been effective against all major schistosome species. It is the only vaccine candidate having consistently exhibited potent prophylactic, anti-fecundity, egg-induced pathology resolving, transmission-blocking and therapeutic efficacy. The objectives are to 1) assess the safety/immunogenicity of SchistoShield® in a Phase I clinical study in healthy adults from Africa; 2) refine and develop a female worm schistosome human challenge model; 3) identify correlates of protection, innate and adaptive immune signatures, gene expression and the role of antibodies in the prevention/control of Schistosoma infections; and 4) foster a global consortium to advance research on schistosomiasis disease burden, vaccines and address downstream access constraints in resource-poor settings. The funding requested will allow the clinical development of SchistoShield®. African site research capacity will be improved and epidemiological burden data using novel diagnostic techniques will be used t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Controlling Influenza A Virus Liquid Organelles' (LOFlu) targeting Horizon 2020.

assistant: **Abstract**

The world health organization monitors viral infections worldwide with the aim to coordinate strategies to control viral outbreaks. The on-demand development of vaccines or antibody treatment does not confer a first line of defense against unpredictable infections caused by new viruses in humans such as pandemic influenza, corona or Ebola viruses, and new approaches are needed. We propose to investigate the fundamental basis of novel host-pathogen interactions in influenza A virus (IAV) infection that may define new antiviral strategies. We discovered that the important pathogen IAV induces the intracellular assembly of viral inclusions that behave like liquid organelles. IAV inclusions serve as assembly sites for the IAV segmented genome, a key step in the viral lifecycle. We now find that the maintenance of the liquid character of IAV inclusions is essential for viral replication. As we identified some of the host and viral components of IAV inclusions, we now have the tools to interrogate how specific interactions and cellular processes result in phase-separated compartments. We aim to learn how the function of IAV inclusions is related to their material state and investigate the potential of imposing phase transitions in an organism to limit IAV infection. Phase separation provides a novel conceptual framework to tackle how viruses exploit cells to organize viral reactions in space and in time. It also provides alternative principles for exploring aspects of the IAV lifecycle not yet fully understood, including how influenza epidemic and pandemic genomes assemble. Taken together, we propose a new, integrated approach for studying phase separated phenomena, from the molecular to the organismal level, that will bring a deeper understanding and control to viral infecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced surgical simulation for tuition and procedure rehearsal' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Of the $20m being spent on Virtual Reality Technologies in the health care industry worldwide nearly 75% is spent in the USA an that 50% is government funded research for primarily military projects. However, the rational for the application of VR technology simulation is not confined to military procedures. UK and European regulatory and certification pressures mean that even a basic fidelity of virtual human simulator is seen as a to development of specific surgical skills. Market forces are driving the development of products to meet this need, however the enabling technology is often not present in the main surgical equipment suppliers. Virtual procedure training will be cheaper, safe faster than other forms of simulated surgery training. Further, virtual procedure training will provide more positive training than ct practices of training based on mock ups using crude substitute materials. VR allows surgeons to practice hundreds of procedures to patient contact, carrying no risk to the patient and improving the success rate of the procedure. The principle industrial objective of the proposed RTD is to provide the European health care sectors with superior training and visualization that has the following advantages over current technology. _ Safe, repeatable, control-lab tools Full and part tasks training Low cost training solution Incorporation of advanced medical imaging technology Provision of tissue deformation feedback whilst also offering a platform for the incorporation of the technology to the following further medical tool developments. _ Surgical Planning, Education,_ Telemedicine,_ VR facilitated rehabilitation keyed displays with real time data fusion, disability solutions and patient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Investigation into reasons for drinking among adolescents and young adults: a gender perspective.' (OH-GENDER), addressing dissemination and exploitation.

assistant: **Impact**

In Europe, 53.5% of adolescents consume alcohol in excess, but what has attracted attention is the increase in consumption among girls. These used to drink less than boys, but now their consumption is equal and on some contexts larger than boys. How this happens in Europe, where it can be considered a trendsetter, should be a global concern. Thus, understanding the reasons for this behavior change is essential to develop prevention program strategies that are effective in young people. Existing programs are not successful, they do not focus on specific gender situations and also on the mechanisms involved in this process. In addition, studies to date do not have a quantitative assessment, as there are no instruments to unravel the reasons for alcohol consumption from the perspective of gender difference. Current studies have only a qualitative assessment, it is impossible to compare groups of people and populations, making a global view of this field unfeasible.Thus, the proposal will unravel the determinants of alcohol consumption in adolescents and young adults from a gender perspective. This will be a paradigm shift in the knowledge of alcohol consumption.OH-GENDER is highly original and innovative as it provides a new instrument for quantitative assessment and will deliver a new model of consumption of alcohol determinants by an advanced technique of statistical analysis (Structural Equation Model) advancing the field of gender disparity. a tool to identify the different needs between girls and boys, disclosing the determinants of alcohol consumption from a gender perspective will be an advance in the state of the art, filling this unexplored knowledge gap. The proposal will advance in the field of alcohol consumption prevention and has the potential to be an ongoin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Gamification of EcoDriving Behaviours through Intelligent Management of dynamic car and driver information' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Driving style is seen not only to become a significant cause of greenhouse gas (GHG) and other air pollutant emissions but also a critical parameter regarding road safety, with huge social & financial adverse effects. GamECAR aims to develop a highly innovative and interactive Serious Games platform that will empower and guide users to adopt an eco-friendly driving style. This will be achieved, without distracting users from safe driving, through a multidisciplinary approach aiming at the development of a user friendly, unobtrusive multi-player gaming environment, where the users will not only play collaboratively/competitively using their mobile device but also using the car itself and their own bodies, thus turning eco-driving into an immersive and highly motivating experience. The sensing infrastructure of GamECAR will not only acquire data related to driving from an OBD sensor that will capture a complex set of parameters related to eco-driving, but will also sense environmental and physiological parameters of the driver, so as to better position the state of the system (car) in context (environment, user). The use of virtual user models and cognitive modeling of the users, will further boost personalization and adaptation of the game itself with respect to the needs of the individual driver.The GamECAR system will be quantified and evaluated in test campaigns with drivers in three different sites. Quantification campaigns serve system development and evaluation campaigns demonstrate usefulness and exploitation potential. Finally, the project has a clear exploitation plan through a balanced and highly complementary composition of SMEs that have specific roles in the development of the integrated GamECAR system.The impact of such a holistic and innovative approach is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Federated CPS Digital Innovation Hubs for the Smart Anything Everywhere Initiative' (FED4SAE).

assistant: **Concept**

The overall ambition of the FED4SAE innovation action (IA) is to boost and sustain the digitization of the European industry by strengthening competitiveness in Cyber Physical Systems (CPS) and embedded system markets. In alignment with the ""Smart Anything Everywhere"" initiative goals, FED4SAE will:- Create a pan-European network of Digital Innovation Hubs (DIH) by leveraging existing regional ecosystems across full value chains and a range of competencies. DIHs will enable both tech and non-tech innovative Third parties (Startups SMEs, Midcaps) from any sector to build new products and services with “digital inside”.- Act as a European added-value one-stop-shop to facilitate innovators-suppliers cross-border partnerships which will accelerate innovation in products and processes of European Third parties by providing technical, industrial and innovation management expertise. This will lead to quantifiable increases in market shares, productivity, industrial capacities of the Third parties, and a broader adoption of CPS and embedded systems solutions.- Link innovators to investors associated to DIHs to reach out to further funding opportunities and enable the next steps of the Third parties’ developments after completing their application experiments (AEs).- Ensure the self-sustainability of the DIHs pan-European network by developing cooperation with regional organizations and key stakeholders engaging public and or private investment to fund FED4SAE network activities.FED4SAE is built upon the key learnings obtained in the EuroCPS, Gateone-project, CPSE Labs IAs. FED4SAE will leverage the best practices related to Third party engagement, submission, evaluation and selection of AEs. FED4SAE will give birth to a competitive ecosystem where European Startups, SMEs and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CD40 goes innate: defining and targeting CD40 signaling intermediates in the macrophage to treat atherosclerosis' (CD40-INN) targeting Horizon 2020.

assistant: **Abstract**

Atherosclerosis, the underlying cause of the majority of cardiovascular diseases (CVD), is a lipid driven, inflammatory disease of the large arteries. Despite a 25% relative risk reduction achieved by lipid-lowering treatment, the vast majority of atherosclerosis-induced CVD risk remains unaddressed.  Therefore, characterizing mediators of the inflammatory aspect of atherosclerosis is a widely recognized scientific goal with great therapeutic implications.Co-stimulatory molecules are key players in modulating immune interactions. My laboratory has defined the co-stimulatory CD40-CD40L dyad as a major driver of atherosclerosis. Inhibition of CD40, and of its interaction with the adaptor molecule TRAF6 by genetic deficiency, antibody treatment or (nanoparticle based) small molecule inhibitor (SMI) treatment, is one of the most powerful therapies to reduce atherosclerosis in a laboratory setting. Although CD40-CD40L interactions are associated with adaptive immunity, I recently identified the macrophage as a driver of CD40-induced inflammation in atherosclerosis. We will use state-of-the-art in vitro experiments, live cell-, super resolution imaging, proteomics approaches and mutant mouse models to unravel the role of macrophage CD40 in atherosclerosis. Moreover, using structure based virtual ligand screening, I will develop lead SMIs targeting macrophage CD40-signaling, which I will deliver using macrophage-targeting nanoparticles. My goal is to define the role of macrophage CD40 in inflammation and immunity and disentangle how its activation affects atherosclerosis. I will finally test the feasibility of targeting macrophage CD40-signaling as a treatment for CVD.These studies will define the role of CD40-signaling in the innate immune system in health and (cardiovascular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterization of the role of Sac1 in the spatiotemporally controlled interplay between PI4P and cholesterol homeostasis' (PIP-AID).

assistant: **Innovation**

Lipids are essential components of cell membranes. Every organelle membrane is constituted of a unique composition of different lipid species. This distinctive lipid distribution along organelle membranes is important to maintain the identity and functions of the different organelles. In this research project, I aim to understand how the lipid species phosphatidylinositol-4-phosphate (PI4P) is regulated and how this affects lipid homeostasis and cellular functioning. The PI4P distribution is important for intracellular signalling, lipid and protein trafficking. Alterations in PI4P levels may contribute to the progression of other neurodegenerative disorders, e.g. Alzheimer's disease. In this project, I will study the PI4P phosphatase Sac1. Sac1 consumes PI4P in the endoplasmic reticulum or Golgi apparatus. This locally lowers PI4P levels, therefore maintaining the asymmetric distribution of PI4P in the cell. The PI4P gradient is important for the transport of lipids and proteins. In cell models, Sac1 knockdown or knockout severely compromises cell viability, whereas Sac1 knockout mouse or drosophila are embryonically lethal. This highlights the importance of Sac1, however, making it difficult to examine the physiological functions of Sac1. In this project, I will use an auxin-inducible degradation (AID) system to induce the degradation of Sac1 within one hour. This allows me to assess the acute effects of Sac1 depletion. Using this model, I will address the following key objectives: 1) Examine the role of Sac1 in lipid homeostasis. 2) Investigate the regulatory mechanism of Sac1 in Golgi morphology and kinetics, and 3) Characterize a inducible degradation system in zebrafish. By employing the AID system in a zebrafish model, I aim to provide a new means to study the rol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Elucidating the molecular mechanism of cohesin-loading', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The cohesin-complex mediates sister chromatid cohesion from S-phase until mitosis and is involved in the formation of higher-order chromatin structure. To fulfill these vital functions, cohesin is loaded and positioned in the genome by mechanisms that are only poorly understood. In vitro, loading of cohesin on DNA only requires ATP and a loading-complex formed by Scc2-Scc4, while loading in vivo on chromatin is regulated by additional factors. For example, in Xenopus laevis oocytes, cohesin loading strictly depends on pre-replication complexes (pre-RCs), which are formed in telophase/G1. Mechanistic studies are required to understand how cohesin-loading occurs at the molecular level. I will first determine the mechanism by which Scc2-Scc4 loads cohesin on DNA. Using single-molecule FRET and optical tweezers, I will monitor the effect of Scc2-Scc4 on conformational changes of cohesin as it is loaded on a DNA template. After characterizing this minimal loading reaction, I will reconstitute cohesin-loading during telophase/G1 using a purified system. With these experiments I will address why and how loading of cohesin is regulated by the formation of pre-RCs.


**Keywords:** cohesin, sister chromatid cohesion, chromatin, cohesin-loading