RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'INTEGRATION OF THE SYSTEM MODELS OF INSULIN SIGNALLING AND OF MITOCHONDRIAL FUNCTION AND ITS APPLICATION IN THE STUDY OF COMPLEX DISEASES' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal is to identify novel mitochondrial-dependent mechanisms responsible for the development of insulin resistance. This will be done by the use of technologies of Systems Biology and the generation of computer-based tools that will permit the study of complex biological systems that integrate different regulatory networks. For the global visualization and interpretation of the “insulin signalling/mitochondria” complex system we plan to develop a computational framework that will store and integrate all possible data for each of the subsystems, both currently available data and data generated within the project by transcriptomics and lipidomics analysis. This will allow the prediction of functional associations and interactions between both processes, which will be tested under specific hypothesis-driven studies in mammalian cells, mice and Drosophila.  By using a Systems Biology approach and investigating how different perturbations modulate cell transcriptomes, and lipidomes, we aim to identify integrated homeostatic responses involving the insulin signalling network and the mitochondria networks. Validation of some of the strongest associations detected by virtue of the integrated systems biology of insulin signalling/mitochondria will generate high value targets of use in therapy against Complex Diseases such as diabetes, obesity, or pathophysiological traits of the Metabolic Syndrome. Besides, computer-based tools generated in the project will be appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Plasma immersed ion implantation for enhancing high precision machining with tools of complex geometry' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Material shaping and forming requires tools which can withstand degradation induced by abrasive or tribochemical wear. Over the past decade a lot of efforts have been made to develop hard surface coatings like TiN, TiC, Al203 and diamond using the physical vapour deposition (PVD) and chemical vapour deposition (CVD) processes. The ever increasing demands for high precision machining and increased cutting performance, in terms of cutting speed and lifetime, require wear resistant tools of large dimensional accuracy that have very sharp cutting edges and/or that are easily re sharpened. All these requirements cannot be fulfilled presently by the classical PVD and CVD technologies since they result in overlay coatings. A possible alternative would be ion implantation but the conventional beam line ion implantation actually in use does not allow the treatment of complex shaped parts such as cutting and forming tools. Recently, a new development in the field of ion implantation has appeared, known as plasma immersed ion implantation (PIII). This process bypasses the aforementioned limitations since the workpieces are immersed into a plasma conformably surrounding it. The ions in the plasma are accelerated by voltage pulses and enter directly into the workpieces, resulting in chemical and microstructural changes of the target surface. The technical relevance of PIII is linked to the cost reduction in comparison to conventional ion implantation and the possibility to implant in a homogeneous and controlled way non metallic and metallic elements in three dimensional targets without any dimensional modification. The objective of this project is to evaluate the potentialities and limitations of the PIII technique for developing high precision machining tools which are not limited
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Metal oxide nanophase materials for environment catalysis'.

assistant: **Innovation**

Research objectives and content Nanophase materials is a new and rapidly expanding field with numerous potential applications in several areas. The suggested program offers good opportunities for training in the synthesis, characterization and the evaluation of the catalytic properties of nanophase doped cerium oxide materials. The ultimate goal is to develop anew catalyst for environmental applications. By proper doping of cerium oxide it may be possible to obtain a more efficient substitute for current car catalysts. Training content (objective, benefit and expected impact) Pr M. Muhammed's group has an excellent experience and knowledge in the synthesis of nanophases and in the study of these ones for catalytic properties. So, my stay will greatly improve my knowledge in this field. Moreover, during my thesis research in collaboration with Rhtne-Poulenc society, I worked on cerium sulfide which will be used as a new red inorganic pigment in plastics. The study of cerium oxide will allow me to show other application of rare-earth element on one hand and on other hand to learn new synthesis processes and physico-chemical characterizations, in particular to determine catalytic properties. Links with industry / industrial relevance (22) The project is of high industrial relevance. Cerium oxide is currently used in noble-metal-based car catalysts. The proper doping of cerium oxide makes possible to reduce or even totally eliminate the amount of noble metals used in such a catalyst. Another advantage of this material is the reduction of the catalyst light off temperature, which greatly decrease emissions due to cold start problem. In this project we have a cooperation with DEGUSSA AG, Germany, where the catalysts synthesized by KTH group are evaluated at DEGUSSA's labs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Selective receptor knock-out in gabaergic interneurones' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content GABAergic interneurones show a large variability in the repertoire of receptors present on their cell surface. Furthermore networks of GABAergic interneurons generate synchronized '40 Hz oscillation' modulating the populations of the principal excitatory cells, a phenomenon underlying the mechanism by which the cortex can associate different features of an object a unified perception. The aim of this research project is the generation of transgenic mice in which one of the GABAA receptors or metabotropic glutamate receptors is selectively knocked out in a specific neuronal population, the GABAergic interneurones, to evaluate if the synchronized 40 Hz oscillation" and the cognitive mechanisms are consequently altered. This result will be achieved using innovative techniques that implies the generation of multiple transgenic mice lines, that can be further used for generating different genetically modified mice lines. Training content (objective, benefit and expected impact) This training period will allow me to learn advanced molecular biology techniques, such as generation of transgenic and knock-out mice, and will complete my scientific experience on the cognitive mechanisms field adding a new focus on the role of the GABAergic neurons. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanoparticle Vaccines: At the interface of bionanotechnology and adaptive immunity' (NANOIMMUNE), addressing dissemination and exploitation.

assistant: **Impact**

We have recently developed a bionanotechnology approach to vaccination (Reddy et al., Nature Biotechnology, 25, 1159-1164, 2007): degradable polymeric nanoparticles are designed that: (i) are so small that they can enter the lymphatic circulation by biophysical means; (ii) are efficiently taken up by a large fraction of dendritic cells (DCs) that are resident in the lymph node that drains the injection site; (iii) activate the complement cascade and provide a potent, yet safe, activation signal to those DCs; and (iv) thereby induce a potent, Th1 adaptive immune response to antigen bound to the nanoparticles, with the generation of both antibodies and cytotoxic T lymphocytes. In the present project, we focus on next-generation bionanotechnology vaccine platforms for vaccination.  We propose three technological advances, and we propose to demonstrate those three advances in definitive models in the mouse.  Specifically, we propose to (Specific Aim 1) evaluate the current approach of complement-mediated DC activation in breaking tolerance to a chronic viral infection (hepatitis B virus, HBV, targeting hepatitis B virus surface antigen, HBsAg) and to combine complement as a danger signal with other nanoparticle-borne danger signals to develop an effective bionanotechnological platform for therapeutic antiviral vaccination; (Specific Aim 2) to develop a new, ultrasmall nanoparticle implementation suitable for delivery of DNA to lymph node-resident DCs, also activating them, to enable more efficient DNA vaccination; and (Specific Aim 3) to develop an ultrasmall nanoparticle implementation suitable for delivery of DNA to DCs resident within the sublingual mucosa, also activating them, to enable efficient DNA mucosal vaccination. The Specific Aim addressing the oral mucosa will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Positive City ExChange'.

assistant: **Concept**

Trondheim, Limerick, Alba Iulia, Pisek, Sestao, Smolyan and Voru and their industry and research partners are joining forces to co-create the future we want to live in. As aspiring Lighthouse and Follower Cities, respectively, they have detailed out their ambitions into the +CityxChange proposal, which describes a structured approach on how to develop and deploy Positive Energy Blocks and Districts and scale these out as part of the Clean Energy Transition.The approach combines: Prototyping the Future through Integrated Planning and Design; Enabling the Future through Creation of a Common Energy Market; and Accelerating the Future through CommunityxChange with all stakeholders of the city.New forms of integrated spatial, social, political, economic, regulatory, legal, and technological innovations will deliver citizen observatories, innovation playgrounds, regulatory sandboxes, and Bold City Visions to engage civil society, local authorities, industry, and RTOs to scale up from PEBs to PEBs to Positive Energy Cities, supported by a distributed and modular energy system architecture that goes beyond nZEB.On top of this, the consortium will create a new energy market design coupled to consumer-driven innovation, developed in close working cooperation with national regulators, DSOs/CSOs, property developers, and local energy communities. Flexibility will be put at the core of the distributed energy system by creating new micro-grid operation, prosumer-driven Community System Operators, and new markets for peak shaving/RES trading to reduce grid investment needs and curtailment.Their aim is to realize Europe-wide deployment of Positive Energy Districts by 2050 and prepare the way for fully Positive Energy Cities.


**Keywords:** Positive Energy Districts, Smart Cities, Ener
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative Model-based Plasma Algorithms for Control of spherical Tokamaks' to be submitted under Horizon Europe.

assistant: **Abstract**

The huge mass of a star and its associated gravitational forces make the nuclei of hydrogen atoms collide and fuse, releasing energy in the form of energetic neutrons. This process, called nuclear fusion, has a very high energy density, and does not produce CO2 or long-lived radioactive waste. For these reasons, nuclear fusion has attracted the attention of scientists since the 1950s, who have tried to reproduce the conditions of a star in their laboratories. So far, tokamaks are the most promising prototype for a nuclear-fusion power plant on Earth. In particular, spherical tokamaks provide an attractive configuration due to their compactness and lower cost than conventional tokamaks. This would provide a means to mitigate the actual climate and energy crisis, using nuclear fusion to complement other renewable energies in a greener future.Control of the tokamak plant and associated systems, whose final goal is to confine a plasma by means of magnetic fields, is critical to attain the necessary conditions for nuclear fusion to happen. However, plasma control in spherical tokamaks requires specific solutions due to their challenging plasma shapes and pressures, which often trigger plasma instabilities. Under the Marie Sklodowska-Curie actions, the IMPACT project (Innovative Model-based Plasma Algorithms for Control of spherical Tokamaks) will design a state-of-the-art plasma-control system for spherical tokamaks and will deploy it on the SMall Aspect Ratio Tokamak (SMART). Under this project, novel algorithms based on plasma dynamical models will be developed to tackle the newest control challenges in spherical tokamaks, including negative triangularity plasma shaping to enable higher plasma confinement and ensure safety of the tokamak reactor. This project will ensure t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Social Interaction Characteristics for Socially Accepted Robots' to be submitted under Seventh Framework.

assistant: **Abstract**

Why robotic research, despite its advances, has not yet lead to the widespread use of robots in operative contexts treatable through human-robot cooperation? The SICSAR project proposes that the main reason resides not in intrinsic technical difficulties, but in the limits of the diffused expectation that, to collaborate with humans, robots need to be almost ""perfect"" - faultless - in their actions. Humans are certainly not perfect agents, and, to achieve common goals during interactions, mutually correct their behaviors to increase their possibilities of success. Transferring this self-other corrective dynamics to human-robot cooperation could be the key to effectively renew the approach to implement this kind of collaboration: renouncing to build ""perfect"" robots, and focusing on creating ""social"" robots, that is, robots able to correct their behaviors on the basis of their capability to understand humans' signals.The proposed project aims at taking a fundamental step in this direction: developing robots able to coordinate their behaviors with those of their human partners. Today this represents a frontier issue also and specifically for HRI and social robotics, which see human-robot ""behavioral coordination"" as a sine qua non condition to integrate robots in our social context(s).The project tackles this issue through a highly interdisciplinary approach, integrating HRI with experimental psychology, robotics and robot design research. It intends to develop hardware and software solutions providing iCub - one of the most sophisticated European robots – with a new ability: competently correlating and synchronizing its interactive movements with those of its human partners during dyadic interactions.As argued in the proposal, the project is expected to have an i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Predicting clinical response to anticancer drugs using 3D-bioprinted tumor models for personalized therapy' (3DCanPredict), addressing dissemination and exploitation.

assistant: **Impact**

Predicting clinical response to novel and existing anticancer drugs remains a major hurdle for successful cancer treatment. Studies indicate that the tumor ecosystem, resembling an organ-like structure, can limit the predictive power of current therapies that were evaluated solely on tumor cells. The interactions of tumor cells with their adjacent microenvironment are required to promote tumor progression and metastasis, determining drug responsiveness. Such interactions do not form in standard research techniques, where cancer cells grow on 2D plastic dishes. Hence, there is a need to develop new cancer models that better mimic the physio-pathological conditions of tumors. Here, we create 3D-bioprinted tumor models based on a library of hydrogels we developed as scaffold for different tumor types, designed according to the mechanical properties of the tissue of origin. As PoC, we bioprinted a vascularized 3D brain tumor model from brain tumor cells co-cultured with stromal cells and mixed with our hydrogels, that resemble the biophysics of the tumor and its microenvironment. Our patient-derived models consist of cells from a biopsy, constructed according to CT/MRI scans, and include functional vessels allowing for patients' serum to flow when connected to a pump. These models will facilitate reproducible, reliable and rapid results, determining which treatment suits best the specific patient's tumor. Taken together, this 3D-printed model could be the basis for potentially replacing cell and animal models. We predict that this powerful platform will be used in translational research for preclinical evaluation of new therapies and for clinical drug screening, which will save critical time, reduce toxicity and significantly decrease costs generating a major societal benef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Icarus Software'.

assistant: **Innovation**

The underlying innovation idea of ICARUS-SW is a software for the identification and prediction of new nanocrystalline alloys with tailored properties. The software can be used as a predictive tool for the exploration, identification and design of new thermodynamically stable multi-component nc metal alloys with enhanced thermal, mechanical and irradiation damage self-healing properties. It allows the systematic exploration of the parameters space defined by chemical composition, microstructure, thermodynamic state functions and properties in search of new families of nc alloys. In preparation of this software, the exploitation, IPR and dissemination strategies will be defined and implemented in this project, based on in-depth market analysis, business planning and other exploitation-related activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High quality research network on nanosciences, material and energy research in Lithuania' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In this proposal, an outline for NENNET, a high quality research network bundling competences in materials sciences, nano-applications and self formation in Lithuania is given. Lithuanian research is strong in the fields addressed by the proposed network. This has been confirmed by an evaluation of the Research Council of Norway. However, links between research and industry continue to be rather weak and there are continue to be potentials for a further integration of the Lithuanian research sector into the European research community. The current integration process into the ED constitutes a strong incentive for Lithuanian research centres to engage in networking activities both inside the countries and with European partners. Lithuanian Centres of Excellen ce understand that they play a key role in making Lithuania an attractive research and development location having its place in the European Research Area. Through the bundling of competences, the integration of industry and society, and the exchange with European partners, the network contributes to the development of a critical mass able to mobilise the resources needed for outstanding research and development and innovation-based growth in Lithuania. This ensures that Lithuania will become an attractive and highly-performing partner in the European Research Area. Reaching the 3 % GDP goal is an ambitious task that, as one main precondition, requires high public awareness concerning the role of R&D for competitiveness, growth and development. The propo sed NENNET is aimed at increasing this awareness through the initiation and moderation of a societal dialogue, for example within the framework of foresight studies or through a web-based communication platform. Policy makers and public actors will be dire ctly addr