RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantum Optical Physics with Neutral-Atom Waveguide-QED' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The coupling of cold atoms to nanophotonic devices has recently opened a variety of novel opportunities for controlling light-matter interactions. Tailored dispersion relations offer unique features beyond conventional settings. In particular, photonic-crystal waveguides enable tight transverse confinement of the propagating light, strong atom-photon coupling in single pass and tunable long-range atom-atom interactions. While this research area is extensively studied theoretically, experimental progress has been much more modest. This project aims at turning the emerging neutral-atom waveguide-QED paradigm into a mature field.The primary challenge will be to develop a versatile apparatus where ensembles of cold atoms can be trapped in the proximity of slow-mode photonic-crystal waveguides, using a specific material, original structure designs and novel atom-delivery techniques. The main project objectives are then threefold:- The demonstration of deterministic photon-photon interaction in a lossless single-pass configuration and its application to efficient quantum state engineering- The realization of multiphoton-state engineering via atomic entangled states and subradiant and superradiant dynamics.- The exploration of  a novel bandgap physics uniquely accessible with the developed photonic-crystal platform for strong atom-atom and photon-photon interactions.The successful realization of the project based upon the interdisciplinary interface of cold atoms and nanoscale waveguides could elevate this approach to a new route for strongly interacting photons and atoms, with unique possibilities for integrated quantum technologies, quantum non-linear optics as well as for many-body quantum physics.


**Keywords:** waveguide-QED, quantum non-linear optics, cold atoms, atomic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ENHANCEMENT OF QUALITY OF FOOD AND RELATED SYSTEMS BY CONTROL OF MOLECULAR MOBILITY' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Most quality changes in food processing and storage, either desired or detrimental, may result from chemical and enzymatic changes, microbial growth, and structural transformations. The key factors controlling these changes, safety, and consumer appeal are composition, temperature, time and water content. Glassy foods are often stable due to restricted molecular mobility while changes occur in the supercooled liquid state above glass transition temperature, Tg. However, very little and controversial data exist on molecular mobility, reaction rates, and microbial growth in concentrated and frozen food systems. In the present work we are concerned with the effects of various types of molecular mobility, i.e., secondary relaxations such as rotation of side chains, glass transition allowing segmental motions, and rotational and translational diffusion on observed changes in food properties and quality. Our project challenge the benefits and applicability of the polymer science theories in improving food quality and safety. The general objectives of the proposed work are : to increase knowledge of various types of molecular mobility in food and related materials and to provide scientific basis for the improvement of food quality and consumer appeal by control of molecular mobility in food processing and storage. A subsidiary objective will be to facilitate the development of non-food products based on renewable biomaterials.The specific objectives of the proposed work are :- to determine various types of molecular mobility in amorphous food and related materials at low-water contents and in the frozen, freeze-concentrated state;- to relate observed molecular mobility to the physical state, composition, water content and temperature;- to establish relationships between molecu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Final 21-cm Cosmology Frontier' (CODEX), addressing dissemination and exploitation.

assistant: **Impact**

Radiation emitted by neutral hydrogen during the Universe's first billion years holds detailed information about its first stars, galaxies, black holes and fundamental physics. Achieving a detection of its faint ""21-cm signal"", currently redshifted to several meter wavelengths, has been extremely difficult due to the bright radio emission from other sources, human-made interference signals, the ionosphere, and telescope imperfections. It thus remains one of the hardest frontiers in present-day cosmology.In the past years, we made tremendous progress in mitigating these challenges, thanks to access to world-class low-frequency radio telescopes and research into innovative data analysis techniques. Using the Low-Frequency Array (LOFAR), we set the deepest limits on the 21-cm signal during the Epoch of Reionization, 500-1000 million years after the Big Bang, and the first limits during the early Cosmic Dawn. We started two innovative programs with AARTFAAC and NenuFAR, targeting the entire span of the Cosmic Dawn (100-500 million years), covering the recently-announced global 21-cm signal from EDGES. Last but not least, we launched the Netherlands-China Low-Frequency Explorer (NCLE) space-mission, currently in lunar L2 as part of the Chinese Chang-e' 4 mission, to set the first limits on the global 21-cm signal from the Dark Ages (20-100 million years). CoDEX draws together these state-of-the-art observational programs and their expertise into a single program, improving current 21-cm power spectrum limits by three to six orders of magnitude, advancing them into the domain of standard astrophysical models from z~8 to ~80. To achieve this, we will process petabytes of data, strengthen efforts in the signal- and data-processing domain and enhance processing capacity. ERC f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative pulse and cereal-based food fermentations for human health and sustainable diets' (HealthFerm) targeting Horizon Europe.

assistant: **Abstract**

Food fermentation has been used for millennia, but our knowledge on the impact of fermented foods on human health and the possible role of gut microbiota in it is limited. Microbial consortia and fermentation processes are, hence, not designed for optimal health outcomes. At the same time, fermentation technology represents a major opportunity to increase incorporation of plant-based proteins in diets. The multi-actor consortium HealthFerm brings together first-class researchers, food companies and dissemination partners to enable the transition from traditional to sustainable grain-based fermented foods and diets that deliver health benefits to consumers by design.This will be achieved by (1) disentangling the interaction between food fermentation microbiomes, grain-based foods and the human gut microbiome and health and (2) using microbial resources and fermentation technology to develop healthy pulse and cereal-based food and diets that cater to the desires and needs of EU citizens. Drawing from a community science approach, HealthFerm will identify micro-organisms and metabolic pathways that may result in desired nutritional and health effects. The impact of microbial fermentation on raw materials will be examined at the molecular level. Fermentation technology will be used in the production of grain-based liquid and (semi-)solid foods. The impact of these foods on human health and the gut microbiome will be assessed in a number of intervention trials. Consumer acceptance of fermented foods, their technologies and their role in the transition towards a more sustainable healthy diet will be studied in different social contexts. Finally, extensive ecosystem building and training activities will contribute to HealthFerm’s strong participatory approach.Outcomes will all
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Impact of Cosmic Rays on Galaxy and Cluster Formation' under Horizon 2020.

assistant: **Concept**

Understanding the physics of galaxy formation is arguably among the greatest problems in modern astrophysics. Recent cosmological simulations have demonstrated that ""feedback"" by star formation, supernovae and active galactic nuclei appears to be critical in obtaining realistic disk galaxies, to slow down star formation to the small observed rates, to move gas and metals out of galaxies into the intergalactic medium, and to balance radiative cooling of the low-entropy gas at the centers of galaxy clusters. This progress still has the caveat that ""feedback"" was modeled empirically and involved tuning to observed global relations, substantially weakening the predictive power of hydrodynamic simulations. More problematic, these simulations neglected cosmic rays and magnetic fields, which provide a comparable pressure support in comparison to turbulence in our Galaxy, and are known to couple dynamically and thermally to the gas. Building on our previous successes in investigating these high-energy processes, we propose a comprehensive research program for studying the impact of cosmic rays on the formation of galaxies and clusters. To this end, we will study cosmic-ray propagation in magneto-hydrodynamic turbulence and improve the modeling of the plasma physics. This will enable us to perform the first consistent magneto-hydrodynamical and cosmic-ray simulations in a cosmological framework, something that has just now become technically feasible. Through the use of an advanced numerical technique that employs a moving mesh for calculating hydrodynamics, we will achieve an unprecedented combination of accuracy, resolution and physical completeness. We complement our theoretical efforts with a focused observational program on the non-thermal emission of galaxies and clust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Business plan optimisation and preparation for scaling of a transcatheter heart valve replacement manufactured using automation'.

assistant: **Innovation**

Lifelet Medical is on a mission to deliver one valve for life for patients suffering from heart valve disease. Lifelet is developing a disruptive polymeric heart valve replacement to transcend the limitations of mechanical and animal tissue-based devices available to patients today. Combining the durability of mechanical valves with the blood compatibility and minimally invasive delivery of animal tissue valves, Lifelet’s fully synthetic device aims to enable improved patient outcomes and reduced complications with easier deliverability, enhanced durability, and cost savings for healthcare systems through automated manufacturing and processing.There are 1.2 million patients in the U.S. with severe aortic valve stenosis, and over half of these patients are symptomatic, requiring a heart valve replacement. The transcatheter aortic valve replacement (TAVR) market size is €4B, expected to growth to €7B+ by 2024, with a double-digit CAGR. Thanks to recent clinical trials, indications are being expanded for younger patients, asymptomatic patients, and those at low and intermediate risk for surgery, driving growth of the market. Cardiologists will Lifelet's device with existing reimbursement in place. As a platform technology, the Lifelet polymer may also offer clinical benefits in the treatment of obesity, gastrointestinal diseases, and incontinence. Elle Sander, female CEO and co-founder, is a biomedical engineer who has led the company to a proof-of-principle in chronic sheep studies and is a lead inventor of the material technology, with one patent granted in the EU already. Co-founder and CMO Dr. Faisal Sharif, consultant interventional cardiologist, has a track-record of implanting new devices and a extensive experience of clinical trial development and operations. The t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'DETERMINING THE FUNCTIONAL CONSEQUENCES OF TRANSCRIPTIONAL ENHANCER ACTIVATION ON ALTERNATIVE SPLICING DURING EMT'.

assistant: **Objectives**

Alternative splicing (AS) is a highly regulated process that is essential for creating the protein diversity required for correct cell-type specification. Misregulation of AS programs can lead to cellular dysfunction, developmental problems and disease, such as cancer. Understanding how alternative splicing is regulated during development and disease is therefore capital.Recent advances in the field have shown that, not only does AS regulation rely on the recruitment of various splicing factors to the pre-mRNA, but other phenomena such as RNA Polymerase II elongation rate, histone post-translational modifications or long non-coding RNAs have been shown to regulate this process.I hypothesize that transcriptional enhancers also play a critical role in the establishment and maintenance of cell-type-specific AS programs. I propose to study the effect of enhancer activation on AS regulation during the epithelial-to-mesenchymal transition (EMT), an important physiological process involved in tumour metastasis and cancer recurrence. Using genome-wide studies, I will map and physically link activated enhancers to intragenic regions of alternatively spliced genes over the course of the EMT in human mammary epithelial cells. I will then employ a candidate-based approach to tease apart the multiple processes through which enhancer activation can regulate splicing patterns, and to discover new enhancer-linked regulators implicated in the AS process.Long-term, this project aims to establish a direct functional link between enhancer activation and alternative splicing during development, with the ultimate ambition of being able to modify AS patterns through the regulation of enhancers. This study will yield results expected to have important implications for the understanding of how
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Metagenomic Analysis of Microbial Communities Involved in Wood Degradation in a Xylophagic Catfish' under Seventh Framework.

assistant: **Concept**

Microbes play an essential role in the global cycling of carbon and nitrogen, but, many of the microorganisms involved in these biogeochemical cycles are, as yet, unculturable using traditional microbiological methods.  Thus, essential microbial interactions and biochemical processes contributing to these cycles await discovery.  Application of molecular tools can overcome limitations of non-culturability, enabling the description of microbial communities.  Fishes of the genus Panaque are capable of long-term survival on a wood-only diet (xylophagy). The microbial communities in the gastrointestinal tract probably contain mechanisms for cellulose decomposition and nitrogen fixation, enabling this xylophagous lifestyle.  In this study, a polyphasic approach will be employed, to overcome limitations of each technique and better describe and understand the microbes present.  In this proposal traditional microbiological culture tools, microbial community profiling using 454-pyrosequencing techniques, fluorescent in situ hybridisations and functional genes analysis will be employed to provide a comprehensive view of the microbial communities present, in the different regions of the gastrointestinal tract.  The major goal of this proposal is examine microbial communities associated with xylophagy and to identify novel microbial metabolic genes, enhancing our understanding of the carbon and nitrogen cycles in the environment.  The study of novel microbes, enzymes and model systems can provide valuable insight into critical metabolic pathways and enable more efficient biotechnological exploitation.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural & dynamical characterization of the pro-metastatic enzyme heparanase for the designing of novel inhibitors' (2002-2006).

assistant: **Innovation**

The focus of the project is the understanding of the biological functions and the structural characterization of heparanase. Heparanase is an endo-b-D-glucosidase capable of specifically degrading heparan sulfate, one of the extracellular matrix (ECM) components. This activity is associated with the metastatic potential of tumor cells, because these cells require the ability to degrade the ECM. During the last decade, NMR spectroscopy has become a leading technique to study biomolecules. Nowadays, its versatility allows the three-dimensional structure determination of biological macromolecules, the characterization of protein dynamics, kinetic and thermodynamic information on protein folding, as well as on molecular interactions.This last issue has revealed NMR as an important tool for the Drug Discovery. The major limitation of NMR arises from the increase of transverse relaxation rates which prevents the investigation of molecules with large molecular weights. Heparanase is initially expressed as a 543 aminoacid polypeptide (65 kDa). The study of a protein of this size represents a challenge for NMR methodologies currently available.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'COLUMBUS - Monitoring, Managing and Transferring Marine and Maritime Knowledge for Sustainable Blue Growth'.

assistant: **Innovation**

We are standing at the dawn of a century that will be largely affected by how we as a society are able to manage our oceans and their resources. Marine and Maritime Research has a critical role to play in developing our understanding of the seas and advance technology so that we can develop their economic potential in a sustainable manner. The COLUMBUS project intends to capitalise on the EC’s significant research by ensuring accessibility and uptake of research Knowledge Outputs by end-users (policy, industry, science and wider society). COLUMBUS will ensure measurable value creation from research investments contributing to sustainable Blue Growth within the timeframe of the project. Adopting proven methodologies and building on significant past work, COLUMBUS will first identify end-user needs and priorities. It will then set about identifying and collecting “Knowledge Outputs” from past and current EC projects. Rigorous analysis will take place to identify specific applications and end-users. Transfer will be achieved and measured through tailor-made knowledge transfer. All knowledge collected will be made accessible the pre-existing Marine Knowledge Gate. To achieve the above, COLUMBUS has brought together a multi-disciplinary, multi-stakeholder team representing all aspects of the research value chain from funding agencies to end-users. Key strategic initiatives and networks further strengthen and provide a strong vehicle for project legacy. A network of 9 Competence Nodes, each with a “Knowledge Fellow” and support team across Europe will provide the necessary critical mass (470pm of effort) to ensure full thematic and spatial coverage. COLUMBUS will also carry out strategic actions to enhance the visibility and impact of research to stakeholders and European Cit