RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Machining with Fine-Beam Abrasive Waterjets' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Profiled parts in metals, ceramics, polymers and composite materials are used in the building of a wide range of machinery and in aircraft, vehicles, consumer products, etc. Abrasive waterjets are the only power beam technology that can accurately profile all of these materials, but profiling costs for some metals can be high in comparison with those of plasma arc and lasers. If abrasive waterjet profiling speeds were improved, in relation to those of plasma arc and lasers, they could become the cheapest method of meeting industrial needs for just in time production of small batches of profiled parts in a wide variety of materials. The objective for the project is to use direct injection of abrasive technology to produce finebeam abrasive jets that improve profiling performance by over 300 percent, compared to existing abrasive waterjets. At the same time, cut widths will be reduced by up to 400 percent, which will enable fine beam abrasive waterjets to compete with CO2 lasers for fine detail profiling. Prototype equipment will be developed to produce fine beam abrasive waterjets down to 0.2 mm in diameter, along with the conerol systems to integrate the fine beam equipment with CNC profiling systems. Low cutting head weights and jet reaction forces will allow X Y and Z manipulation systems to be assembled from widely available modular linear motion components. Within the project, techniques will be developed to use fine beam abrasive waterjets in profiling, cutting, drilling and slotting of metals, ceramics, polymers and composite materials. New production processes will be developed that exploit the precision of fine beam jets and their potential to drill small diameter holes ( < 0.5 mm) and produce narrow slots (< 0.2 mm) in materials up to 10 mm thick. The Consortiu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hydrous phases in the Earth’s lower mantle' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The origin and survival of life on Earth depend on the availability of water. Plate tectonics connects the Earth’s surface with its deep interior and promotes exchange of H2O between the surface and the Earth’s mantle. The resultant deep H2O cycle has affected the evolution of the oceans and atmosphere on Earth and supplies H2O to the mantle. Rocks of the upper mantle may store H2O as defects in the crystal structures of nominally anhydrous minerals (NAMs). The NAMs of the lower mantle, however, incorporate significantly less H2O. As a consequence, the contribution of the lower mantle to the deep H2O cycle has been discounted as minor. HYDROSPHEAR challenges this paradigm by investigating the storage of H2O in solid hydrous phases (SHPs) and hydrous melts of the lower mantle.Phase D and phase H are SHPs that form at pressures and temperatures of the lower mantle. The stability limits of phase D and phase H in complex chemical systems and in realistic phase assemblages remain largely unconstrained, in particular, at pressures of the deeper lower mantle. HYDROSPHEAR will determine the stability limits of these SHPs in rocks of the lower mantle by performing high-pressure melting experiments.Melting reactions will be sampled in laser-heated diamond anvil cells (DACs). We will detect the formation of a melt phase by Brillouin spectroscopy and, in the same experiment, measure the speed of sound in the hydrous melt. Brillouin spectroscopy will also be used to determine the elastic properties of single crystals of SHPs at high pressures and high temperatures. Complementary high-pressure experiments in DACs and multi-anvil presses will constrain the equations of state and phase relations of SHPs.The experimental results will be integrated into a systematic search for hydrous ro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Automatic Hydraulic Jack with improved capacity, safety and efficiency for agricultural implements' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Following comprehensive research and consultations with the actual users of jacks in the agricultural sector, the health and safety of the operators relating to physical, repetitive manual jack activities and the potential for lost time and injuries was a major concern. Statistics show that 49% of critical injuries in agriculture are a direct result of being crushed under a tractor or being crushed between a hydraulically mounted machine and vehicle. The removal of manual operations would be an obvious benefit to both employers and employees within the agricultural sector. Simol is an award winning European leading manufacturer of support feet with over 50 years’ experience in the production of supplies for the agricultural sector. We aim to respond to these concerns by producing a simpler, quicker and less labour intensive alternative to the current state of the art, Novel Jack. Novel Jack is a fully automatic hydraulic jack with increased capacity and minimum encumbrance unlike current state of the art. It is also ISOBUS compliant, ensuring that it will be compactable with implements from different brands thus making it a universal solution. Our innovation is 40% cheaper than current solutions and has 64% more lifting capacity with the same functionalities. Novel Jack will result in a 90% reduction in jack related accidents and 80% of jack related downtime of agricultural implements. Novel Jack currently stands at a TRL6, with a first real scale prototype having been developed by our internal team of experts and lab tested. The next steps are to optimise our initial designs, as well as test it in real world conditions before commercialisation. The commercialisation of Novel Jack will consolidate Simol’s position as a global leader in the manufacture and distribution o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Leukocyte immunoglobulin-like receptors (LILRs) on neutrophils' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Neutrophils provide the first-line of antimicrobial defence and orchestrate inflammation. They are tightly regulated by ligand-receptor interactions to ensure pathogen clearance and to prevent host damage. Targeting receptors, with natural or synthetic ligands, that control neutrophil functions is a promising strategy to control infections and inflammation. However, basic knowledge on the role of certain receptors in neutrophil biology, and their interactions with pathogens, has been neglected. This includes leukocyte immunoglobulin-like receptors (LILRs), a family of surface receptors that are potent regulators of immune cell activity and potential targets of immunotherapeutic strategies. The major aim of this project is to comprehensively understand how LILRs regulate neutrophil functions, to identify bacterial ligands of LILRs and to test whether each bacteria-derived LILR ligand has pro- or anti-inflammatory properties that could be exploited in future immunotherapeutic strategies. For the first time, we will extensively characterise the functional role of four representative LILRs in controlling neutrophil functions. We will screen our newly developed high-throughput bacteria secretome phage display libraries, representative of 20 pathogens and the entire human gut microbiome, for identifying bacterial molecules that bind to LILRs. Finally, we will determine whether each of the ligands acts as a LILR agonist or antagonist. These experiments build upon expertise and preliminary results of the applicant, and upon unique resources of the host. The proposed experiments will expand knowledge of the function of poorly studied LILRs on neutrophils. This will advance knowledge of neutrophils, immune responses and bacterial pathogenesis, paving the way for identifying new s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovation services for enhancing SME innovation management capacities in Madrid Region' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

“IInnovation services for enhancing SME innovation management capacities in Madrid Region- INNMADRIMASD 3” is a proposal addressing the topic ‘Enhancing SME innovation capacity by providing better innovation support “under Horizon 2020. INNMADRIMASD 3 will provide innovation services to SMEs in Madrid through the Enterprise Europe Network as a suitable structure to provide in depth support services to SMEs in the area of innovation management. Furthermore, beneficiaries of the SME Instrument under Horizon 2020 will be entitled to receive specific targeted support from the Enterprise Europe Network to support coaching assignments addressing specific innovation weaknesses for Madrid based SMEs.


**Keywords:** Innovation management, SME instrument, Innovation services
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Controlling epileptic brain networks with computationally optimized weak electric fields', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Epilepsy is a neurological disorder affecting 65 million people worldwide. Pharmacological treatments or surgery are ineffective in one third of the cases – 19 million people. Recent findings indicate that non-invasive brain transcranial current stimulation (tCS) is safe and of therapeutic promise in epilepsy. However, it is not yet indicated as a standard treatment due to major scientific limitations: unknown mechanisms of action, insufficient account for patient-specific factors, poor understanding of short- and long-term effects.Our ambition is to transform the care of a large fraction of patients living with drug-resistant epilepsies by solving a fundamental problem: to efficiently target and control large-scale epileptic brain networks with tCS-induced neuromodulatory weak electric fields.To proceed, GALVANI’s synergetic research strategy addresses four interdisciplinary challenges: (1) Unravel the intricate relationship between weak electric fields and their neurophysiological effects at the level of neurons, neuronal assemblies and networks; (2) Maximize their therapeutic effects by altering the neurodynamics of patient-specific epileptogenic networks; (3) Develop optimal personalized neuromodulation protocols for novel multichannel tCS technologies; (4) Test optimized protocols in a cohort of patients and objectively define potential responders.The required competences and resources are met in GALVANI, uniting the passion and background of three experts and their teams in biomathematics (computational neuroscience), biophysics (bioelectromagnetism) and medicine (epileptology).The project vision is that critical features of pathological networks can be effectively captured in a new generation of hybrid computational models developed for tailored therapy. The infl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The immunopathology of T cell-induced chronic inflammatory bowel disease' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

- To determine the phenotype, cytokine profile, antigen receptor repertoire and cell cycle kinetics of T cells infiltrating epithelial and lamina propria compartments of the lesion. - To investigate the antigen processing and presentation capacity of macrophages and dendritic cells in the lesion. - To study the involvement of cytokines in the induction and maintenance of the lesion. - To investigate the role of B cells (immunoglobulin isotype secretion and switch), antibodies and complement in initiating and sustaining the lesion. - To investigate intestinal epithelial cells (MHC class II expression, antigen uptake, antigen processing, macromolecular permeation). - New therapeutic approaches (cytokine substitution, antibodies, adoptive cell transfer) for control of this disease will be tested.Despite extensive research over several decades, the aetiologic agents and the events initiating and sustaining chronic inflammatory responses in the gut (chronic inflammatory bowel disease (IBD)), remain largely unknown. Recently a new murine model for inflammatory bowel disease (IBD) was developed in which disease development can be initiated by transplantation of limited numbers of purified CD4+ T lymphocytes into severe combined immuno deficient (scid) mice which lack immuno- competent T and B cells. Using this adoptive T cell transfer model it is now for the first time possible to analyze the individual cellular and humoral components of the immune system which initiate and sustain the pathological changes leading to the chronical inflammatory pathology of IBD. The present proposal aims to analyze these components: main research topics are mucosa infiltrating T cells (T cell receptor repertoire, lymphokine profiles, cell cycle status), B cells (immunoglobulin isotype secretion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Up to 70% of cardiovascular events are not prevented by current therapeutic regimens. In search for additional, innovative strategies, immune cells have been recognized as key players contributing to atherosclerotic plaque progression and destabilization. Particularly the role of innate immune cells is of major interest, following the recent paradigm shift that innate immunity, considered to be incapable of learning ability, does exhibit a memory feature transduced via epigenetic modulation. Compelling evidence shows that atherosclerotic factors promote immune cell migration by pre-activation of innate immune cells. In this project called REPROGRAM, we aim to prove that innate immune cell activation via epigenetic reprogramming perpetuates the upheld systemic inflammatory state in cardiovascular disease which is common in other chronic inflammatory diseases. This opens a new therapeutic area in which epigenetic modulation of innate immune cells effectively decreases systemic inflammation impacting on chronic inflammation as well as the development of co-morbidities. The integrated use of in vitro, ex vivo and in vivo studies, including cells, mice and patients, allows translation from in vitro mechanisms to diseases (molecule-to-man) and extrapolation to cohorts (man-to-mass), enabling us to demonstrate relevance and therapeutic potential of targeting trained immunity in cardiovascular and chronic inflammatory diseases. Enforced by the promising data in oncology, the future prospects for epigenetic interventions in cardiovascular and chronic inflammatory diseases are eminent, attested by the large residual cardiovascular disease burden and the huge societal impact of other chronic inflammatory diseases. The REPROGRAM consortium consisting of key opinion leaders in the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Wage Negotiations and Gender Pay Gaps: Exploring the Role of Fairness Attitudes in Europe' to be submitted under Horizon Europe.

assistant: **Abstract**

In the EU, addressing the gender pay gap, defined as the difference in earnings between men and women, is a significant policy challenge. Despite concerted efforts, this disparity persists, exhibiting noticeable differences across member states. Recent changes in the European labor market, such as the reduced role of unions and the shift towards individual pay negotiations, may amplify these disparities. Individual pay negotiations increase the responsibility of employees in determining their pay. Men typically achieve more favorable outcomes than women in these individual pay negotiations. Thus, the increasing prevalence of individual pay negotiations in Europe may lead to the widening of the gender pay gap. A vital aspect of this research is the focus on fairness norms in pay negotiations and their impact on the gender pay gap. Prior research reveals that perceptions of pay fairness are often subconsciously skewed against women. This project explores under what conditions pay fairness attitudes develop a gender bias and how they subsequently influence the outcomes of pay negotiations. To investigate this, I will conduct unique surveys across selected European countries, examining the origins of gender-biased fairness attitudes and their effect on negotiation behaviors and the gender pay gap. These surveys will incorporate experimental elements to assess causal relationships. By integrating these empirical studies within a unified theoretical framework, the project seeks to offer a comprehensive understanding of gender biases in pay negotiations and their broader implications for the labor market. In sum, this project tackles a vital gap in our knowledge regarding the gender pay gap, focusing on the influence of fairness norms in wage negotiations. It represents a crit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'RESILENS: Realising European ReSiliencE for CritIcaL INfraStructure', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Critical infrastructure (CI) provides the essential functions and services that support European societal, economic and environmental systems. As both natural and man-made disaster and crises situations become more common place, the need to ensure the resilience of CI so that it is capable of withstanding, adapting and recovering from adverse events is paramount. Moving resilience from a conceptual understanding to applied, operational measures that integrate best practice from the related realm of risk management and vulnerability assessment is the focus of the RESILENS project. RESILENS (Realising European ReSILiencE for CritIcaL INfraStructure) will develop a European Resilience Management Guideline (ERMG) to support the practical application of resilience to all CI sectors. Accompanying the ERMG will be a Resilience Management Matrix and Audit Toolkit which will enable a resilience score to be attached to an individual CI, organisation (e.g. CI provider) and at different spatial scales (urban, regional, national and transboundary) which can then be iteratively used to direct users to resilience measures that will increase their benchmarked future score. Other resilience methods including substitution processes and measures to tackle cascading effects will also be developed. The ERMG and resilience management methods will be tested and validated through stakeholder engagement, table-top exercises and three large-scale pilots (transport CI, electricity CI and water CI). The ERMG and accompanying resilience methods will be hosted on an interactive web based platform, the RESILENS Decision Support Platform (RES-DSP). The RES-DSP will also host an e-learning hub that will provide further guidance and training on CI resilience. Overall, RESILENS aims to increase and optim