RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Highly-efficient biomass CHP plants by handling ash-related problems' (Biofficiency).

assistant: **Concept**

Medium- to large-scale bioenergy utilisation for electricity and combined industrial or district heating is predicted to increase by 160% in 2020 compared to 2010, while carbon emission quotas are becoming stricter. Finding new ways to efficiently utilise cheap and currently unused feedstocks are necessary in order to meet these challenges.Within the project Biofficiency we will investigate how to handle ash-related problems in order to increase steam temperatures up to 600°C in biomass-based CHP plants, including pulverised fuel and fluidised bed systems. The major aspects are fly ash formation, the use of additives, and pre-treatment technologies for difficult fuels. This leads to highly reduced emissions, in particular CO2 and fine particulates, as well as a secure and sustainable energy production. Biofficiency gathers a unique consortium of excellent academic facilities and industrial partners, providing an exceptional platform for the development of new, highly-efficient CHP plants in order to significantly expand their potential in the fast-growing field of renewable energies. By sharing our collective experience, we will strengthen European bio-energy technologies and help solving global climate and energy challenges. The project approach addresses current bottlenecks in solid biomass combustion, namely enhanced deposit formation, corrosion and ash utilisation by a variety of new, promising technologies. Our goal is to deepen the understanding of fly ash formation, to improve current biomass pre-treatment technologies, as well as to contribute to the field of biomass ash utilisation. Through our strong collaboration with industry and academic partners, we want to pave the way for highly-efficient, low-emitting biomass CHP plants, capable of firing low-grade fuel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metric measure spaces and Ricci curvature — analytic, geometric, and probabilistic challenges' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project is devoted to innovative directions of research on metric measure spaces (‚mm-spaces’) and synthetic bounds for the Ricci curvature. It aims to bring together two - currently unrelated - areas of mathematics which both have seen an impressive development in the last decade: i) the study of ,static‘ mm-spaces with synthetic Ricci bounds and ii) the study of Ricci flows for ,smooth‘ Riemannian manifolds. A new ansatz - based on the concept of dynamical convexity - will enable to merge these two cutting-edge developments and will lead to the very first approach to Ricci flows on singular spaces. The project also aims to break up the limitations for the study of (generalized) Ricci curvature for mm-spaces, until nowbeing restricted exclusively to spaces with uniform lower bounds for this curvature. For the first time ever, mm-spaces with(signed) measure-valued lower bounds for the Ricci curvature will be studied - the absolutely continuous, non-constant case being highly innovative as well. Besides Ricci bounds also Ricci tensors will be defined and utilized for novel insights andsharp estimates. Furthermore, the project aims to initiate the development of stochastic calculus on mm-spaces and, in particular, to provide pathwise insights into the effect of (singular) Ricci curvature. The focus will be on pathwise optimal coupling, stochastic parallel transport, and derivative formulas. Both the static and the dynamic case are of interest. Methods from optimal transport and from stochastic calculus will be combined to push forward the analysis on path and loop spaces.Each of these aims is important and worth in its own. Only in combination, however, they produce the dynamics, synergy effects, and cross-fertilization requested for maximum success. The anticipated b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bioorthogonal Photocatalytic Activation of Metal-Based Prodrugs' (ORTHOCAT), addressing dissemination and exploitation.

assistant: **Impact**

New cancer care methodologies with fewer side effects and no need for major surgery are required to enhance patient wellbeing. Photodynamic Therapy (PDT) partially accomplishes such mission employing light and a photosensitizer. Nevertheless, the PDT mechanism of action intimately depends on oxygen, which limits its efficacy, particularly in hypoxic solid tumours. Promising strategies to improve the impact of PDT in the clinics currently involve the design of photoactivatable transition metal complexes, a class of compounds which combines the rich photochemistry of metal complexes with the vast background of metal-based drugs in cancer therapy.In this framework, ORTHOCAT proposes an original and multidisciplinary strategy to exploit the efficiency and selectivity of riboflavin as unconventional photocatalyst for the activation of Pt(IV) anticancer prodrugs (Chem. Sci. 2017, 8, 4619). The project aims at designing novel riboflavin-based catalytic systems capable of activating Pt(IV) anticancer prodrugs inside the mitochondria of tumour cells. In particular, I will use triphenylphosphonium targeting vectors to develop new photocatalytic prodrug systems and delivery nanoplatforms which selectively accumulate in the mitochondria. Once in the organelle, riboflavin will act as singlet oxygen photosensitizer for PDT and simultaneously as photocatalyst to generate Pt(II) species for targeting mitochondrial DNA (photochemotherapy). Imbalance of mitochondrial delicate redox homeostasis by ORTHOCAT dual agents can trigger cell death through convenient cellular pathways. Therefore, ORTHOCAT prodrug systems will synergistically kill cancer cells with increased effectiveness, while potentially reducing side effects of metal-based drugs. Successful outcome of the project has the poten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Easy to use, contactless Dual-Mode Ultrasound Technology for high accuracy treatment of Atrial Fibrillation, improving outcomes' (DMUT), addressing dissemination and exploitation.

assistant: **Impact**

Our mission is to radically change the landscape of cardiac ablation. Our products, based on proprietary ultrasound technology, allow contactless tissue ablation with real-time lesion monitoring, bringing Healium to the forefront of the cardiac ablation market. Our team, backed by scientific and business advisors, includes Dr. Eckhouse, Chairman, leading medical entrepreneur who has founded >20 companies, and cumulated >1B in exits (Ventor for $325M, Synron and Lumenis both IPO > $1B). Ran Sela, CEO and co-founder, >15 years of medical device development and project management. Dr. Megel, CTO, and co-founder, >25 years in ultrasound-based medical devices. Now, we are at the top-risk phase of our development journey: the transition from preclinical to clinical studies. Leveraging an EC investment of 12.75M we can demonstrate the efficacy and safety of our product, establish a manufacturing line and regulatory framework, and access the market as a self-sustained company.


**Keywords:** electrophysiology,microelectronics,ultrasound ,catheter ablation,cardiology,engineering and technology,atrial fibrilation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Towards a quantitative framework for understanding protein-protein interactions: from specific effects to protein ecology'.

assistant: **Concept**

Non-covalent protein-protein interactions underlie most of biological activity on the molecular level.  A binding event between two proteins typically consists of two stages: 1) a diffusional, non-specific search of the binding partners for each other, and 2) specific recognition of the compatible contact surfaces followed by complex-formation.  Despite significant progress in studying these processes, a number of open questions remain.  How do partners find each other in the crowded and interaction-rich cellular environment?  What are the exact mechanisms of the specific recognition of binding surfaces?  What is the role of induced fit as opposed to conformational selection in the process?  We propose to utilize atomistic-level and coarse-grained molecular dynamics simulations and advanced computational techniques in close collaboration with experiment to address these questions, with the ultimate goal of developing a unified picture combining both specific and non-specific contributions to protein-protein interactions.  We will focus on several test-cases of broad biological significance, such as the ubiquitin system, to test two central ideas: 1) that protein dynamics is the principal determinant of specific molecular recognition in many systems, and 2) that co-localization, which non-specifically affects the binding process, is a direct consequence of the general physico-chemical properties of the binding partners, irrespective of the features of their binding sites.  Methodologically, we will further develop and utilize distributed computing techniques on the world-wide-web and computation on streaming processors to meet the high demand for computational power, inherent in studying protein interactions in silico.  In our work, we will closely collaborate with exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Role of European National Health Services in the enhancement of sustainable food systems'.

assistant: **Innovation**

The European food systems are unsustainable, within a Europe confronting increased environmental degradation, diet related diseases and inequality. Healthcare systems have the capacity to influence the current status quo of food systems towards sustainable means. However, sustainable food system policies are recent and yet poorly implemented within the European health Services. A lack of assessment and target setting for decision making do not ease up the process. The objective of the present proposal is to explore the food system processes related with the economic and educative channels of the European health services from a sustainable dimension and to develop the first System of Indicators that will aid up in the decision making of those processes. The (co-)generation process of the System of Indicators will be via qualitative methodology. A transdisciplinary approach will be used when using the DELPHI methodology and the panel of expert for the theoretical validation of the System of Indicator. A practical phase will also be carried out to validate the System of Indicators against real cases. Additionally, during a secondment phase, we are going to lead the process of the development of a territorial strategy on food systems in health-care within the Basque region, bridging the research into policy making through participatory-action research. The knowledge obtained in this project will be used to develop strategies to target more efficiently the sustainable goals of the United Nations 2030 agenda in Europe. The Fellow will be up-skilled (in new research skills and techniques) to advance in the development of a career path towards sustainable science, to translate her background knowledge into a continuing research environment and to build and maintain links with o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PIVOTAL ASSESSMENT OF THE EFFECTS OF BIOACTIVES ON HEALTH AND WELLBEING. FROM HUMAN GENOMA TO FOOD INDUSTRY - PATHWAY' to be submitted under Seventh Framework.

assistant: **Abstract**

Scientific understanding of the role and mechanisms of bioactives is fragmented. Research often addresses the theoretical possibility of health improvement effects rather than their real, practical use for everyday diets. Bioactives cannot be considered as discrete chemical compounds and research must focus on bioactive-enriched foods (BEF), if consumer demands for foods delivering appropriate health and wellbeing benefits are to be fulfilled.PATHWAY, a pan-European interdisciplinary team of 16 life/social scientists and 10 high tech/ food processing SMEs, uniquely addresses the role and mechanisms of action of 3 bioactives (docosahexaenoic acid, β-glucan, anthocyanins, chosen for known/claimed effectiveness in reducing some risk factors of Metabolic Syndrome (MS), enriching 3 different widely-consumed food matrices (dairy-, bakery-, egg products). Critical evaluation of bioactive-food matrix interactions and determining the extent of synergies between the 3 bioactives are key elements of PATHWAY.PATHWAY will determine the impact of BEF on physiologically-relevant MS (a risk factor for many diseases) endpoints and deliver a better understanding of the role and mechanisms of action of the 3 bioactives and BEF. Parallel in vitro/in vivo studies will enable selection of robust biomarkers by advanced omics techniques.Deliverables will include BEF and generic protocols, best practices and guidelines for planning dietary interventions, and guidance to SMEs for producing health-promoting BEF and for submitting convincing health claim dossiers to EFSA; the latter will be greatly facilitated by one SME partner who has submitted 3 successful dossiers. PATHWAY guidelines will be generic and will apply to a wide range of bioactives and BEF.Impact will be optimised across Europe by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project '6G eXperimental Research infrastructure to enable next-generation XR services' (6G-XR).

assistant: **Concept**

6G eXperimental research infRastructure to enable next-generation XR services (6G-XR) will develop an evolvable experimental infrastructure for the duration of the SNS programme that covers demonstrating the performance of key B5G/6G candidate technologies, components, and architectures to keep the infrastuctures valid now, in mid-term and in long-term. It will demonstrate technological feasibility of “better than 5G” KPIs, innovative radio spectrum technologies and the use and sharing applicable to beyond 5G and 6G spectrum, validate a representative end-to-end beyond 5G architecture (and later 6G) including end-to-end service provisioning with slicing capabilities, and at cloud implementation level (Open RAN).Furthermore, 6G-XR shall validate multi access edge computing scenarios and their integration into a complete cloud continuum, support innovative use cases with vertical actors, beyond 5G capabilities, and support showcasing events. In addition, 6G-XR demonstrates and validates performance of innovative 6G applications with a focus  on demanding immersive applications such as holographics, digital twins and XR/VR. 6G-XR will support impactful contribution to standards and demonstrate the technological feasibility of key societal requirements and objectives such as energy reduction at both platform and network levels.


**Keywords:** B5G, 6G experimental platform, network enablers, RAN enablers, holography, XR, Digital Twin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structural and Biochemical Examination of the Yeast U4/U6 snRNP.' in the context of a Seventh Framework call.

assistant: **Objectives**

The spliceosome is a large RNA–protein assembly that catalyzes the removal of introns from mRNA precursors (pre-mRNA) and the splicing of coding exons to produce mature mRNAs.  Four small nuclear ribonucleoprotein particles (U1, U2, U5 and U4/U6 snRNPs) assemble onto pre-mRNA substrates together with non-snRNP proteins to form the spliceosome.  After binding of the U1 snRNP and the U2 snRNP to the 5’ splice site and the branch point sequence within the intron, a pre-assembled U4/U6.U5 tri-snRNP joins and the spliceosome undergoes extensive remodeling to yield the catalytically active spliceosome.  In the tri-snRNP, the U4 and U6 snRNAs are extensively base-paired but upon activation this duplex is unwound by an RNA helicase, Brr2p.  The ultimate aim of this project is to determine the structure of the U4/U6 snRNP by X-ray crystallography and reveal details of spliceosome activation/mechanism.  This work will initially employ electrophoretic gel mobility shift assays and gel filtration chromatography for characterization of assembly, isothermal titration calorimetry to identify/quantify protein-protein interactions, chemical/enzymatic RNA footprinting to identify protein-RNA contacts and protein-induced conformational changes in the RNA, and pulse-chase quantitative mass spectrometry to further substantiate and characterize the pathway of assembly of the U4/U6 snRNP and the U4/U6.U5 tri-snRNP biochemically and thermodynamically.  These experiments will also aid crystallization.  Unwinding directionality and helicase-induced protein displacement by the U5 snRNP protein Brr2p will be examined in the context of the fully assembled U4/U6 snRNP and tri-snRNP complexes.  This will reveal details of spliceosome activation/mechanism.  The proposed project will exploit my extensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Aircraft Loads Prediction for Enhanced Simulation' (ALPES).

assistant: **Concept**

A European Industrial Doctoral (EID) network is proposed to improve the prediction, and also the efficiency in calculation, of aircraft loads.  The loads experienced by an aircraft in-flight (due to manoeuvres and gusts) and on the ground (e.g. landing, turning, braking) are the key element in determining the structural sizing and hence its weight.  Although the structural design must ensure that structural failure cannot occur at any point of an aircraft’s operation due to excessive stresses or deflections, the aircraft weight must be as small as possible.  If it were possible to obtain more accurate loads predictions than at present at the edges of the flight envelope and other critical points, and also to consider uncertainties in the calculations, then it would be feasible to produce lighter aircraft designs which are more efficient and more environmentally friendly.  A further requirement is to be able to turn around all the many required loads calculations much faster, enabling a much more thorough search of the possible design space, particularly for the novel aircraft configurations that are likely to occur in the future. The ALPES (Aircraft Loads Prediction through Enhanced Simulation) EID will consist of five PhD researchers working on interrelated aircraft loads projects:  Modelling of Landing, Manoeuvre and Gust Loads for Flexible Aircraft Structures for investigating combined high load events,  Reduced Order Aeroelastic Modelling during Landing, Manoeuvres and Gusts,  Efficient and Accurate Gust Loads Modelling, Worst Case Prediction of Gust, Manoeuvre and Landing Loads, Uncertainty Quantification of Landing, Gust and Manoeuvre Loads.   Combined with a novel research programme, a highly industrially focused training schedule is planned, including placements