RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Real-time microscopic chemical imaging: The application of novel, laser-based, tunable mid-infrared sources to new techniques in spectrally-resolved microscopy.'.

assistant: **Concept**

Microscopic Chemical Imaging (MCI), microscopic imaging with chemical specificity, has clear importance in, for example, screening biopsy samples studies of cellular structure and interface chemistry. MCI in the 3-20?m region of the mid-infrared (MIR), whe re most molecules show characteristic absorption spectra, is a rapidly developing field due to improving MIR imaging detectors. Laser illumination has recently been shown to offer important advantages over thermal sources generally used in the field. Howev er, even state-of-the-art MIR lasers have limited tuning ranges requiring the use of many devices to cover the MIR region. The proposed programme will exploit recent advances in fibre lasers and non-linear optics to develop broadly-tuning MIR sources for u se in MCI. Tuneable MIR radiation will be generated from high-power near-infrared fibre lasers by the use of optical parametric oscillators (OPOs) and difference frequency generation (DFG). The use of such sources in MCI will be evaluated and novel techniq ues unavailable with conventional sources, such as frequency-agile, video-rate real-time MCI will be investigated. While advancing this active research area, the proposed programme will also provide valuable training for the applicant. Working within the h ost¿s existing collaborations, both national and international, will enable the acquisition of new skills in the fields of high-power fibre lasers and MIR non-linear optics. MIR imaging techniques specific to the proposal will also be learned. Furthermore, involvement in administering various research programmes, will provide experience in project and financial management, acquiring funding, participating in international collaborations and supervising junior researchers. The combination of inter-disciplina ry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Neural mechanisms for memory retrieval' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Memory is one of the most extraordinary phenomena in biology. The mammalian brain stores billions of bits of information but the most remarkable property of memory is perhaps not its capacity but the speed at which the correct information can be retrieved from a pool of thousands or millions of competing alternatives. Despite more than hundred years of systematic study of the phenomenon, scientists are still largely ignorant about the mechanisms that enable mammalian brains to outperform even the best search engines. One of the greatest challenges has been the dynamic nature of memory. Whereas memories can be retrieved over time periods as short as milliseconds, underlying coding principles are normally inferred from activity time-averaged across many minutes. In the present proposal, I shall introduce a new ¿teleportation procedure¿ developed in my lab to monitor the representation of past and present environments in large ensembles of rat hippocampal neurons at ethologically valid time scales. By monitoring the evolution of hippocampal ensemble representations at millisecond resolution during retrieval of a non-local experience, I shall ask(i)what is the minimum temporal unit of a hippocampal representation,(ii)how is one representational unit replaced by the next in a sequence,(iii)what external signals control switches between alternative representations,(iv)how are representations synchronized across anatomical space, and(v)when do adult-like retrieval mechanisms appear during ontogenesis of the nervous system and to what extent can their early absence be linked to infantile amnesia.The proposed research programme is expected to identify some of the key principles for dynamic representation and retrieval of episodic memory in the mammalian hippocampus.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sewage sludge reuse with Phosphate recovery and heavy metal absorption with an innovative HTC technology.' (HTCycle), addressing dissemination and exploitation.

assistant: **Impact**

Efficient municipal waste-water treatment, such as the systems currently in place in most European municipalities, produces vast amounts of sewage sludge. The latest data collected show a yearly production of 9.637 thousands of tons in the EU28 countries. Sludge treatment issues are often neglected in comparison with water-related parameters which results in serious technical difficulties and highly expensive disposal methods. As a result, an energy efficient, environmentally sound and economically viable process for sludge disposal and reuse of valuable resources e.g. phosphorus hardly exists.The most common disposal methods for sludge are spreading on agricultural soil, composting and incineration. Land-filling has been long banned, the use as fertilizer, although very moderate in costs, is being banned in many regions due to concerns about contamination of soils with heavy metals and endocrine disruptive compounds. Composting raises the same concerns, and it is a labour-intensive and unsafe process, which leaves incineration as the most used option, albeit an expensive and not effective one. Incineration entails the highest costs (80-110 € /ton), but is also considered the safest disposal method and is fast growing and widely adopted. It presents also technical difficulties, such as the low overall efficiency of the process, the huge logistic efforts required to transport the sludge to the incineration plants, or the disposal of the ashes after the sludge has been incinerated.In this situation, our company, AVA has the objective to demonstrate and commercialize our proprietary technology for hydrothermal carbonization (HTC) of sewage sludge, showing clearly technical and economic ad-vantages against the current sludge incineration method. We aim to increase the amoun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multifunctional permeable barriers carrying well-performing microbial biofilms for treatment of mixed pollutant plumes' to be submitted under Fifth Framework.

assistant: **Abstract**

Groundwater polluted with complex mixtures of pollutants form a major threat for European drinking water resources. The permeable barrier technology is a sustainable in situ system to reduce risks associated with polluted water flowing in the direction of groundwater resources but is not suitable for plumes containing mixtures of pollutants. This project aims at developing a Multifunctional Permeable Barrier, which combines different principles of barrier technology, i.e. the removal of pollutants based on both physico-chemical (chemical reductive dechlorination/sorption) and biological activities (biofilm on carrier material) to treat mixed polluted plumes. The project foresees the development from lab scale to pilot scale of the system, the selective enrichment of specifically designed biofilm communities, the characterisation of the microbial populations and of the pollutant removal/degradation pathways.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Brain Endothelium - TARgeted Gene therapy to improve Aβ clearance in Alzheimer’s Disease'.

assistant: **Objectives**

Alzheimer disease (AD) is the most common cause of dementia (60-80% of cases) with a prevalence near 50 million people. There is no cure available and there are only two classes of approved drugs that are effective in treat some of the cognitive symptoms and potentially delay the clinical decline. Despite the considerable progress achieved in the research of best performing disease-modifying agents, the main clinical challenge remains the accomplishment of an efficient and safe therapeutic option that can arrest the disease progression and prevent cognitive failure.  In this project, I am proposing an innovative approach to improve AD pathophysiology by targeting the brain endothelium to improve the Amyloid-β (Aβ) clearance using gene therapy. I will use super-selective nanocarriers to carry relevant genes for the enhancement of the Aβ clearance mechanism. These nanocarriers will be functionalised to allow the specific targeting of brain endothelial cells and to increase its potency to deliver the therapeutic gene into these cells. This project will combine for the first time, the use of super-selective binding strategies and gene therapy for brain endothelium targeting and modulation in the context of AD.  Overall, I will develop an innovative therapy for AD treatment, capable of reaching the BBB in a non-invasive way, being able to target the brain endothelium, overcome the defective Aβ transendothelial clearance, and potentially arrest the disease progression and prevent cognitive failure. Therefore, this project will reach a global impact by substantially contributing with a novel avenue to change the clinical course of AD pathogenesis.


**Keywords:** blood brain barrier, gene delivery, transcytosis, Amyloid-β transport, Alzheimer disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HUB OF CIRCULAR CITIES BOOSTING PLATFORM TO FOSTER INVESTMENTS FOR THE  VALORISATION OF URBAN BIOWASTE AND WASTEWATER' (HOOP).

assistant: **Innovation**

The HOOP Project will help to unlock bio-based investments and deploy local bio economies in Europe through a systemic and cross-cutting approach. It will offer Project Development Assistance (PDA) to a group of 8 lighthouse cities and city clusters - to build the technical, economic, financial and legal expertise needed to develop concrete investments to valorise OFMSW (Organic Fraction of Municipal Solid Waste) or UWWS (Urban Wastewater Sludge) with the aim of obtaining safe and sustainable bio-based products. Each PDA will contain detailed implementation assistance and a defined Circular Business Model tailored to each participating lighthouse city, as well as financing mechanisms to be used for mobilising investment. Moreover, HOOP will launch stakeholder engagement and citizen science initiatives to allow for the co-design of an improved collection of OFMSW for its later optimum valorisation. It will promote behavioural change and acceptability of biowaste-based products, as well as food waste prevention.The HOOP Project will also feature the HOOP Urban Circular Bioeconomy Hub (UCBH), an online platform that will provide opportunities to replicate the PDAs of the lighthouse cities in other follower cities (currently composed by 26 committed cities from all around Europe) – under the launch of the Network of Follower European Cities. HOOP continues the work of the projects VALUEWASTE, Scalibur and WaystUP!, funded under topic CE-SFS-25-2018 and coordinated by the three technical leaders of HOOP. The HOOP Consortium covers the whole value chain, from biowaste recovery to valorisation and characterization of the final products and unites complementary stakeholders with the deep multi-disciplinary knowledge crucial to PDA creation and the achievement of project objecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dramatically reducing spreading of invasive, non-native exotic species into new ecosystems through n efficient and high volume capacity Ballast Water Cleaning System (OCEANSAVER)', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Transport of micro-'organisms in ballast water represents a major contributor to spreading of invasive, non-native exotic species into new ecosystems which can result in serious effects on sensitive ecological communities around the world. Both regions in the North Sea and the Mediterranean have experienced uncontrolled growth of killer algae reaching pest proportions in many areas and causing huge economic impact by killing fish in fish farms' The degree of microbiological growth depend in several factors such as water temperature, sunlight and the amount of nutrients in the waterO,21, and microbiological growth in ballast tanks results in increased maintenance of these tanks including use of VQC containing tank coating products. Microbiological growth, and especially of sulphate reducing bacteria, is 'enhanced in ballast tanks where sediments have accumulated due to ballast water not being filtered by intake, as the situation is for most ships today. In 1997 the Commission proposed a European Parliament and Council Directive establishing a framework for Community action in the field of water policy (Water Framework Directive, WFD). This Directive will replace, the emission control policy established under Council Directive 76/464/EEC, and be the WFD will be the basic legislation for the protection of the European aquatic environment.Our project will directly contribute to the objectives of the Water Framework Directive by contributing to reduction in water pollution and maintaining the biodiversity in coastal areas and waterways across the EU by contributing to reduction in spreading of non-native exotic micro-organisms to vulnerable ecosystems, the IPPC Directive, i.e. the "Council Directive concerning integrated pollution prevention and control (96/61/EEC)" and also
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A reliable CXCL4 biomarker assay to improve diagnosis and treatment of Systemic Sclerosis' to be submitted under Horizon 2020.

assistant: **Abstract**

Systemic Sclerosis (SSc, scleroderma) is a complex autoimmune disorder of unclear aetiology, culminating in excessive extracellular matrix deposition (fibrosis/tissue scarring) in skin and internal organs (e.g. joints, heart, lung, gastrointestinal tract and kidneys). More than half of the patients will ultimately die as a result of organ complications. The medical need is exacerbated by the lack of curative treatments and the lack of specific and sensitive molecular markers to facilitate reliable diagnosis and prognosis.My team has recently demonstrated, through research funded by the ERC Starting Grant CIRCUMVENT, that the chemokine CXCL4 is a central player in the pathogenesis of SSc. Our results suggest that CXCL4 has great potential as 1) a biomarker to assist early diagnosis, 2) a biomarker to predict SSc disease course, and 3) a therapeutic target for the treatment or prevention of fibrosis in patients with SSc. Currently, a robust, accessible, reliable, cheap and fast assay to determine CXCL4 levels for clinical use is lacking. This prohibits the use of CXCL4 to predict clinical and treatment outcome and complicates the large-scale replication experiments across multiple labs and cohorts that are necessary to validate the diagnostic value of CXCL4. Therefore, we argue that a reliable in vitro assay measuring circulating CXCL4 levels is highly needed and can be deployed as a research support tool to accelerate the implementation of clinical strategies based on CXCL4 and a clinical decision support tool in SSc to complement current diagnostic protocols. ASSYSt will focus on 1) the development of a reliable assay to adequately determine circulating CXCL4 levels irrespective of sample collection and storage conditions, 2) assessing the market potential of each of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intergenerational Spillovers of Paternity Leave' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Recent evaluations show that paternity leave reforms have successfully increased fathers’ involvement in childcare and have contributed to a shift in gender norms. But whether this shift in gender norms can be passed on to the next generation and affect children’s real-life decisions remains to be seen. This study thus fills an important gap since preference formation and social norms have been found to be the main contributor to the persistence of gender inequality over time.The objectives of this research project are twofold. First, it will determine whether the introduction of paternity leave can promote counter-stereotypical attitudes that are transmitted from parents to children. A survey of young adults exposed (or not) to a father eligible for paternity leave will be conducted to measure attitudes toward gender roles. Second, the study will evaluate whether paternity leave has spillover effects on the next generation’s real-life decisions. As such, it will use register data to observe whether young adults’ human capital, labour supply, or fertility decisions are affected by their father’s use of paternity leave.To evaluate the intergenerational spillover effects of paternity leave, this research proposes to analyse the 2002 Belgian paternity leave reform, which offers an appealing setup. Indeed, Belgium was an early adopter of paternity leave policies, introducing a two-week leave in 2002. The children of Belgian fathers have therefore entered adulthood and will be 22 years old in 2024. To measure the causal effects of the paternity leave reform across generations, the study will use a natural experiment that relies on the fact that when paternity leave was introduced in Belgium in 2002, only fathers of children born after July 1 were eligible to take the paid le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Decoding neuropeptide function in inhibitory amygdala microcircuits' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Adaptive behaviour to ever-changing environments is crucial for an animal’s survival in conditions of immediate threat. Meanwhile, there is growing evidence that psychiatric conditions, including anxiety disorders, are at least partly based on maladaptive learning. Neuropeptide signalling plays a key role in regulating synaptic plasticity and hence learning in a state-dependent manner, and dysregulated peptide signalling has been observed in patients suffering from psychiatric disorders. Due to specific expression of peptides and their receptors in distinct cell types and microcircuits, they can contribute to the specificity of neural communication on both temporal and spatial scales. However, the signalling mechanisms and behavioural roles of neuropeptides in individual circuit elements are not well understood. In this proposal, we will use a multimodal approach to determine the role of neuropeptides in innate and learned fear and anxiety states. We will focus on microcircuits of the amygdala, more specifically on distinct interneuron types, which co-release different peptides with their common main transmitter GABA. Using state-of-the-art technology, we will analyse under which conditions neuropeptides are released from interneurons, and probe their causal contribution to fear learning and anxiety states with intersectional genetic interrogations. Large-scale, longitudinal in vivo calcium imaging combined with novel spatial transcriptomics will further reveal peptide impact on circuit computations. As both amygdala circuitry and function as well as neuropeptide expression are evolutionarily conserved, we expect that this proposal will unravel fundamental mechanisms of neural circuit functions for survival. This research will not only provide novel insights into the ne