RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring Complex Realities Around Gender Based Violence, Multiple Legal Orders and Role of Police in Addressing GBV Cases in Pakistan and Pakistani Immigrant Community in Norway' under Horizon Europe.

assistant: **Concept**

Violence occurs in all countries, rich or poor, developed or developing, irrespective of caste, creed, color, social status, wealth, urban or rural residence, or the ages of victim and aggressor. Keeping this in mind, this study is designed to understand gendered aspects of Gender based violence in Pakistan and Pakistani Families living in Norway.  Despite extensive legislation and steps taken by the federal and provincial government, the plague of GBV is at rise in Pakistan and rest of the world. Interestingly, to address the GBV issue at state level, community policing has emerged as an alternative approach to conventional, top-down approach to ensure Human security . Community policing also addresses gender inclusive policing which in response provides room to address serious issues like gender based violence. Such community based approaches to policing are instrumental in addressing the sensitive issues like GBV, however, the effectiveness of these approaches in complexed contexts are under-researched and debated in recent scholarship. Similarly, it is equally interesting to understand the choices people make in legally pluralistic societies because it will provide greater understanding to reflect on how people maneuver, negotiate and choose the legal system to address GBV .  At the Norwegian  level, it would be very valuable to review how police works with GBV victims from immigrant communities from Pakistan .Hence, there is need to understand the gaps and challenges within the designed mechanism to curb GBV with special focus on gendered social relations, legal pluralism and why it is important for police to understand contextual complexity . Qualitative data collection method will be used to   collect data both from Pakistan and Norway. Study is framed from grain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Imaging Fibrosis - Chemistry and Optical Confocal Laser Endomicroscopy' (ImagFib).

assistant: **Concept**

Fibrosis, or scarring, is a process which complicates many diseases of the lung and other organs and for which there is no current treatment. It is also associated with many cancers. Fibrotic diseases constitute a heavy burden of morbidity and untimely deaths. There are currently no ways to detect the activity of fibrosis in human tissues in life. The aims of the project are to generate and validate, in a biological setting, a series of probes for the detection and analysis of fibrosis in vitro and in vivo. This project aims to develop ‘smart’ probes to detect fibrosis in ‘real time’. This will be achieved by the combined application of organic synthesis and ‘cutting-edge’ technology to perform optical imaging microscopy deep in diseased organs to detect the activity of a ‘tiny’ dose of a coloured compound which has been designed to specifically detect key events in the fibrotic process. The biological targets chosen  are well recognised as key components of the fibrogenic pathway and are amenable for optical imaging using probe-based confocal laser endoscopy. The research pathway detailed herein will create novel active chemical “smartprobes” as markers of fibrogenesis in situ to rapidly establish early diagnosis and efficacy of much needed new therapies in scarring diseases of the lung and other organs. This technology will enable us not only to detect fibrosis, also to develop new drugs for human disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrated Implementation of Industrial Innovations  for Offshore Wind Cost Reduction' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Led by market leader Siemens Gamesa, drawing on best-in-class partners covering the full value chain of offshore wind energy, i4Offshore will demonstrate the break-down of cost-barriers of large-scale offshore developments. At a commercial, challenging, farshore, deepwater Vattenfall site, a highly innovative offshore system solution featuring a Siemens Gamesa next-generation direct drive wind turbine, a hybrid-material gravity jacket foundation that is optimised for low cost manufacturing, and new very-low-cost array cable-in-pipe solution will be installed and operated as a full size demonstrator during the project.  The project is much more than a technology demonstration. i4Offshore combines the technological advances with deep but targeted study of holistic concepts for leaner manufacturing, onshore and offshore transport of components for full scale operation, innovative strategies for operation and maintenance as well as for offshore logistics and installation. The mitigation of bottlenecks in the value chain will be given special attention. Reduction of cost is the paramount concern across all stages of the offshore wind manufacturing, construction, installation, operation, maintenance and decommissioning process, whilst safeguarding the highest standards of health, safety and ennvironment.  Enabled by the innovative concepts for manufacturing, logistics, installation, and O&M, validated data from the installed and operated wind turbine system will validate the commercial viability of implementing GW-sized offfshore wind farm consisting of the i4Offshore field-proven solution. The new offshore solution will consist of new, modularized components which allow leaner, faster, more reliable and much more cost-efficient logistics in the transportation, handling, inst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The evolution of the human hand: grasping trees and tools' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The unique manipulative abilities of the human hand have fascinated scientists since the time of Darwin. However, we know little about how these unique abilities evolved because we have lacked, (1) the necessary fossil human (hominin) evidence and (2) the appropriate methods to investigate if, when and how our early ancestors used their hands for locomotion (climbing) and manipulation (tool-use). The GRASP project will use novel morphological, experimental and biomechanical methods to investigate different locomotor and manipulative behaviours in humans and other apes, and will use this knowledge to reconstruct hand use in the most complete early hominin hand fossils, those of Australopithecus sediba. The goal of GRASP is to determine the evolutionary history of the human hand by addressing two fundamental, yet unresolved, questions: (1) Were our fossil hominin ancestors still using their hands for climbing? (2) When and in which fossil hominin species did stone tool-use and tool-making first evolve? These questions will be addressed via three objectives: First, microtomography and a novel, holistic method (MedTool®) will be used to analyse the internal bony structure of human, ape and fossil hominin hand bones. Second, collection of the necessary biomechanical data on (a) the loads experienced by the human hand during tool-use and tool-making, (b) hand use and hand postures used by African apes during locomotion in the wild and, (c) the loads experienced by the bonobo hand during arboreal locomotion. Third, data from the first two objectives will be used to adapt musculoskeletal models of the human and bonobo hand and, through the creation of 3D biomechanical (finite-element) models, simulate natural loading of individual hand bones in humans, bonobos and fossil homini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of antigens recognised by T lymphocytes on human tumours, and pilot vaccination studies with defined antigens', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

At the present time several antigens have been identified that are recognised on human tumours by autologous cytolytic T lymphocytes (CTL). Many of these antigens are encoded by genes that are very selectively expressed by tumour cells. Therefore, it is now reasonable to try to immunise cancer patients against such tumour antigens to stimulate or to induce tumour rejection responses. A first part of the project is the identification of new tumour rejection antigens recognised on human tumours by CTL. We intend to identify new antigens by applying to other types of tumours the methods that were successfully used with melanoma antigens. We will derive CTL clones against cell lines derived from renal, bladder, head and neck, and cervical carcinomas, from lung tumours, sarcomas, and leukaemias. After the identification of the HLA molecule which present the antigen recognised by a given CTL clone, the antigen will be identified by cloning the gene coding for the antigenic peptide, using transfection of cDNA libraries derived from the tumour cells. Another approach will involve the elution of the antigenic peptides bound to the HLA molecules expressed by the tumour cells. Using a combination of chromatography and mass spectrometry, it was possible to identify and to sequence individual peptides recognised by CTL clones. The third approach consists in identifying antigenic peptides that are derived from proteins encoded by genes which are known to be selectively expressed in tumours. Candidate peptides that are able to bind to defined HLA molecules will be identified. These peptides will be used in vitro to stimulate T lymphocytes from normal individuals and from cancer patients. The lytic activity of the responder CTL will be tested on tumour cell lines expressing the relevan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Modelling the impact of climate extremes'.

assistant: **Objectives**

It is widely recognized that the impacts of climate change will be manifest more through changes in extremes than as a result of changes in the mean climate. It is the aim of MICE to study changes in extreme event occurrence resulting from anthropogenic climate change, as predicted for Europe by global and regional climate models; and to evaluate the impacts of the predicted changes on selected categories of the human environment and activities. Spatial and temporal patterns of extreme event occurrence will be analysed for precipitation (flood, drought and snow lying), temperature (heat stress) and windstorm. MICE will estimate likely future changes in extremes and define the uncertainties. The impacts of interest are forestry, agriculture, energy use, tourism, and property and life insurance. Interpretation of the results for use by stakeholders and policy-makers is central to the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Accurate reconstruction of microbial genomes from the environment'.

assistant: **Concept**

Metagenome-assembled genomes (MAGs) obtained from metagenomics are of fundamental value to understanding diverse ecological niches of microbes such as the human gut, with applications in medicine, biotechnology, and climate science. However, the quality of MAGs constructed with state-of-the-art tools is often unsatisfactory and worse than the self-reported quality. The main source of error is binning, a computational step that groups sequences assembled from short sequencing reads (contigs) into species-wise bins. The two chief challenges are accurately binning (1) genomes with low abundance and (2) highly conserved regions. Due to cross-mapping of reads, the contigs from conserved regions appear to have abundances equal to the sum of the abundances of the related species or strains. As conventional binning tools all rely on clustering contigs according to their abundances across samples, conserved regions end up forming separate bins. Besides, most existing methods optimise quality measures (purity and completeness based on conserved marker genes) and assess the final quality on these very measures, leading to highly optimistic results. I aim to solve these problems by developing a binning algorithm that applies i) linear mixture models using non-negative matrix factorization to account for cross-mapping,ii) Poisson statistics to accurately model low abundance, and iii) Bayesian statistics-based multinomial clustering to calculate bin numbers. Importantly, it does not require marker gene-based quality measures for binning.By improving the binning of low-abundance and highly conserved contigs, this approach should yield more high-quality MAGs, thereby enhancing a multitude of downstream metagenomic analyses for all areas of microbiome research.


**Keywords:** Metagenom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Econometric analyses and indicators on the impact of Research and Innovation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The project aims: (a) to provide statistical support for the development and update of indicators used by DG RTD to monitor development on science, technology and innovation; (b) to carry out statistical and econometric analysis in order to better understand the nature, needs and determinants of high-growth enterprises, as well as the policy responses and the framework conditions needed to facilitate the growth of companies in innovative sectors; (c) to explore the relationship between inward and outward foreign direct investment flows in R&D and framework conditions such as the tax system/tax incentives (R&D tax incentives in particular); (d) to provide econometric and statistical support on ad-hoc requests by DG RTD on the topics analyzed in this proposal; and (e) to carry out a Counterfactual Impact Evaluation study in order to evaluate the impact of DG RTD research funding schemes on the knowledge basis, innovation activities and economic performance of private enterprises. The project builds on work carried out in the context of the INNOVA MEASURE I (FP7, 2013-14) and INNOVA MEASURE II (H2020, 2015-17) projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ophtalmic Device for eYe StructureS Examination with Ultrahigh reSolution' (ODYSSEUS).

assistant: **Concept**

Non-contact cell-resolution imaging of the whole eye is the Holy Grail of ophthalmic diagnosis. If achieved and wide-spread, it can allow detection of diseases at the very earliest stages, resulting in a prominent positive effect both on society through improving the ocular health in the population, and on economy through reducing the number of costly surgical interventions at the late disease stages and through keeping the population economically active. Several highresolution eye imaging instruments reached the market, however they failed to become wide-spread due to their great complexity, high price (Adaptive optics systems) and not patient-friendly imaging procedure, for example, requiring contact with the eye during examination (Confocal microscopy systems). In a course of ERC HELMHOLTZ project, we for the first time we applied Full-field Optical Coherence Tomography (FFOCT) technology to ophthalmology and built two instruments for corneal and retinal imaging. We demonstrated the unique abilities of FFOCT technology to visualize live retina and cornea of the eye with cell-resolution, in a non-contact way, using a simple optical design without complex adaptive optics. In ODYSSEUS we propose to develop a single combined FFOCT instrument for both corneal and retinal examination. The instrument will be compact, cost-effective, adapted for use in clinical environment and will demonstrate the improved imaging performance, meeting the desires of our partners in the hospital. The developed technology will be transferred to our partners in Vision Institute and the Hospital for clinical studies in patients. In addition, we have filled the first patent on ophthalmic FFOCT and, once the prototype is validated, we plan to create a start-up, specializing in manufacturing and sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sweet Origins of Life:  Peering into the Past with Today’s Biochemistry' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Approximately four billion years ago, chemical and geological processes on the ancient Earth caused a continuous increase in the complexity of organic molecules, ultimately leading to RNA, DNA, proteins, polysaccharides, membrane-forming amphipaths, to metabolism and the roots of biology. But how did it all begin? How did chemistry become biology? There are many indications to the starting point, i.e., the huge set of small molecules that existed on early Earth, as well as the end point of chemical evolution - which is the beginning of biology and the first living organisms. In order to unravel the gap of what happened in between, it is crucial to analyze plausible routes to the origin of life. While much effort to date in the context of formation of primordial polymers has focused on the generation of nucleic acids, and to a lesser extent the formation of peptides, the role of sugars in the chemical origins of life has never been investigated - outside the roles of sugars as structural elements of nucleic acids and in metabolism.Sugars are ubiquitous biomolecules, providing an energy source, taking part in biosynthesis, providing structural support, and even acting as catalysts. Sugars are often found in conjugation with other biomolecules (e.g., glycolipids). I hypothesize that the tightly intertwined biological dependencies of sugars and other biopolymers, and their mutualistic relationships, reflect a long co-evolutionary process. The main goal of this proposal is to bridge the gap from early prebiotic chemistry to today’s complex biochemistry by studying mutually catalytic networks involving sugars. Following our preliminary findings which successfully demonstrated the formation of oligomers composed of sugars and amino acids, my team will generate and characterize
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Prodrugs oF antiparasitic RedOx-active compoundS' (FeROS).

assistant: **Concept**

With 600,000 deaths per year, malaria remains the most devastating parasitic disease for humans. The efficiency of artemisinin-based combination therapy, the spearhead of malarial treatment, is now threatened by the development of drug resistant parasites displaying enhanced transmission potential to mosquitoes. Chagas disease, leishmaniasis and schistosomiasis are neglected tropical parasitic diseases that are considered as the greatest missed opportunities atop the priorities for WHO. The FeROS project is based on the discovery of promising non-quinonoid chemotypes as precursors of 3-benzylmenadiones, with specific antiparasitic profiles depending on the substitution pattern. FeROS will follow convergent and complementary objectives: (i) to develop innovative and specific antiparasitic prodrugs in specific series of optimized drug-candidates to reach total cures in infected animal models for four human parasitic diseases, (ii) to extend the concept to animal health, (iii) to draw structure-activity relationships in in vitro and in vivo parasite assays, (iv) to build innovative chemical tools to visualize the release of active principles under ROS fluxes, in living parasites upon drug treatment, (v) to decipher the molecular and cellular mechanisms that underlie prodrug antiparasitic activities and selectivity. FeROS is built on the multidisciplinary expertise of 7 laboratories from France, Belgium, Switzerland and USA. In an interdisciplinary approach, we will combine a large set of expertise, ranging from medicinal chemistry, physico(bio)chemistry, proteomics to parasite genetics and molecular and cellular parasitology to optimize the antiparasitic non-quinonoid prodrugs of 3-benzylmenadiones, to unravel their mode of action and take them to early clinical studies.