RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Boosting advanced doctoral training in innovative colon targeting drugs' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Colon Targeting Network (COLOTAN) is a European Training Network that will train 13 Early Stage Researchers (ESRs) in (bio)pharmaceutical sciences to improve targeting of oral drugs to the colon.Oral administration of drugs is the preferred delivery route due to its non-invasiveness and convenience for the patient. However, issues related to solubility, absorption, and metabolism often cause oral drug candidate attrition. Oral formulations that release the drug in a pH- or time-dependent manner in the colon have been developed for local treatment of colonic diseases. However, currently available colon-targeting formulations suffer from an inconsistent performance and lack of efficiency due to intra- and interindividual (patho)physiological variability. Moreover, the available tools to predict drug absorption mainly focus on the upper gastrointestinal tract and fail to recapitulate events occurring in the colon, resulting in a lack of validated models to predict drug and formulation behaviour in the colon. To meet these challenges, we must move beyond traditional, mainly monodisciplinary education and train a new generation of pharmaceutical scientists in diverse disciplines ranging from drug delivery to chemistry, cell biology, microbiology and gastroenterology.In an ambitious intersectoral environment, COLOTAN will deliver this new generation via an advanced research and training programme with a total value of 180 ECTS comprising challenging Individual Research Projects, workshops with joint training in scientific and transferable skills, online training, individual training, dissemination, outreach and career development activities. At the end of the project, all ESRs will obtain a doctoral degree. This new generation of ESRs will become future leaders in academi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Book Science in the Bolton Library', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Bolton Library, newly housed at the University of Limerick (UL), is one of Ireland’s most important private library collections. It is currently part of a major conservation effort aimed at saving the books from decades of damage. However, some of the earliest books are too fragile for conservators to handle easily. My project pilots a new application of micro computed x-ray tomography (µCT) that will facilitate the conservation of these important books while revealing new information about the history of the Irish book. I have four main aims: first, to examine the bindings of the medieval books in the library in order to learn more about the cultural and intellectual contexts of book production and collection during early English colonialism. Second, to position these books within a global network of trade in materials and craft techniques. Third, to pilot a novel use of µCT in special collections care, particularly as a means of understanding the status and structure of fragile items in order to plan treatment. Finally, to establish a network of scholars to support further studies in book science in Ireland and internationally. The research takes place in three overlapping phases detailed in my work packages. All of the medieval books in the library will be assessed and catalogued during the data collection phase. Suitable books will be selected for µCT imaging at UL’s Bernal Institute. Processing of the primary data takes place in a second phase, when any further lines of scientific enquiry will be pursued. In the second year I will translate this quantitative data into qualitative argument. Guided by new analytical approaches, my project will reveal the full significance of the materials and structures that medieval books in Ireland comprise: advancing a new hol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transforming SMEs in Creative Sectors through Business Model Innovation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Business model innovation has to do with inventing and implementing new models for doing business and creating value. As such, business model innovation can be viewed as a process of transformation and reinvention (hence, the acronym for this project).Because of the unique importance of small and medium-sized enterprises (SMEs) and the creative sectors for Europe, Reinvent will have SMEs in creative sectors as its empirical focus.Reinvent will develop knowledge about how SMEs in creative sectors – SMEs operating in both digital and non-digital markets - can implement business model innovation as a means to enhance competitive advantage, and put this knowledge into practice in three SMEs. Reinvent will create opportunities to evaluate and validate business model innovation as a competitive tool for European SMEs through empirical research among SMEs in the partner countries.The research to be conducted in Reinvent is particularly relevant right now as Europe faces the challenge of finding ways out of the current economic recession. Identifying the keys to creating successful business models with which recovery based on innovation and entrepreneurship in the creative sectors can be achieved is particularly urgent.Reinvent will have substantial impact for European SMEs, which need approaches, methods and tools to develop competitive strategies. Reinvent will develop, implement and evaluate tools for business model innovation. Developing the capability for business model innovation in SMEs across a range of creative sectors will contribute to European firms’ ability to create and maintain competitive advantage. A comprehensive impact and dissemination strategy has been devised, including dissemination and networking aimed at the general public, policy makers, academia and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Transforming brain surgery by advancing functional-guided neuronavigational imaging'.

assistant: **Objectives**

In recent years, through the advancement of imaging technologies (such as MRI, PET, CT, among others) clinical localisation of lesions of the central nervous system (CNS) pre-surgery has made possible for neurosurgeons to plan and navigate away from functional brain locations when removing tumours. However, neuronavigation in the surgical management of brain tumours remains a significant challenge, due to the inability to maintain accurate spatial information of lesioned and non-lesioned locations intraoperatively. To answer this challenge, we have put together a team of engineers, physicists, data scientists and neurosurgeons to develop an innovative, all-optical intraoperative imaging system based on (i) hyperspectral imaging (HSI) for rapid, multi wavelength spectral acquisition, and (ii) artificial intelligence (AI) for image reconstruction and molecular fingerprint recognition. Our intraoperative HSI system (HyperProbe) will (1) map, monitor and quantify biomolecules of interest; (2) be handheld and user-friendly; (3) apply AI-based methods for the reconstruction of spectral images, the analysis of spatio-spectral data and the development and quantification of novel biomarkers. We will validate the developed capacity in phantoms, in vivo against gold standard modalities in neuronavigational imaging, and finally provide proof-of principle during brain tumour surgery. HyperProbe aims at providing functional and structural information on biomarkers of interest that is currently missing during neuro-oncological interventions.


**Keywords:** Neuronavigation, Neurosurgery, Hyperspectral Imaging, Functional Imaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Purified natural and recombinant allergens with novel th1 adjuvants for use in allergen-specific immunotherapy' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Approximately 20% of the world's population displays allergy symptoms (rhinitis, conjunctivitis, asthma) in response to common substances such as pollen, mite, and pet dander. Specific immunotherapy (SIT) is the only treatment that attacks the root of allergic disease rather than merely alleviating its symptoms. Many researchers believe that this approach may one daybed used during the first years of life to block the progression of respiratory allergy. However, the allergen extracts currently used for immunotherapy are crude, ill-defined preparations. As result, the outcome of SIT can be unpredictable and carries with it the risk of side effects and serious adverse reactions. Obviously SIT can never be used for preventive vaccination purposes in children and will only be used to treat the most serious allergy cases until these risks are eliminated. This emphasizes the need to search for novel forms of safer immunotherapytreatments. This project proposes to develop new, well-defined and standardized immunotherapeutics with reduced anaphylactic potential for the treatment of four common allergies: grass pollen, tree pollen, and house dust mite and cat dander.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Radical Solutions for Hysteresis in Single-Molecule Magnets' in the context of a Horizon 2020 call.

assistant: **Objectives**

Single-molecule magnets (SMMs) display magnetic hysteresis that is molecular in origin, and these materials have huge potential to be developed as nano-scale devices. The big challenge is to create SMMs that function without the need for liquid-helium cooling.This project will develop new SMMs that combine the strong magnetic anisotropy of lanthanide ions with a series of novel radical ligands. Our innovative SMMs will have controllable molecular and electronic structures, which will ultimately enable hysteresis at unprecedented temperatures.Highly unusual di- and tri-metallic Ln-SMMs are proposed in which the metals are bridged by radicals with heavy Group 15 (phosphorus-bismuth) and Group 16 (sulphur-tellurium) donor atoms. Trimetallic SMMs will also be based on hexaazatriphenylene (HAT) radicals, and dimetallic SMMs will also be based on nindigo radicals, both of which are nitrogen-donor ligands.The SMM field is dominated by systems with diamagnetic ligands. Our radical ligands have never been used in SMM studies: their diffuse unpaired spin provides a way of switching off the quantum tunnelling mechanisms that otherwise prevent hysteresis. We will exploit the rich electrochemistry of the target ligands: heavy p-block radicals have huge spin densities on the donor atoms; HAT radicals can have up to three unpaired electrons; reduced or oxidized nindigo radicals allow access to redox-switchable SMMs. In the HAT-bridged SMMs, the use of ligands with more than one unpaired electron is unprecedented. The heavy p-block ligands are themselves are novel.The PI’s approach to SMMs has already established new directions in lanthanide chemistry and in molecular magnetism. He now proposes a new, radical approach to SMMs with potential to re-define the state of the art, and to ext
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Physical Activity & Nutrition: Advancing Measurement & Impact Assessment' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Poor diet, insufficient physical activity, and obesity are leading causes of premature mortality worldwide. Efforts to improve population diets, increase physical activity, and reduce obesity rates are hampered by: limitations in the measurement of dietary intake and physical activity levels; lack of quantification of the long-term impact of promising behaviour change interventions on population health; and lack of comparable estimates of cost-effectiveness for interventions. This multidisciplinary joint exchange programme will integrate research from well-established teams in the United Kingdom, Republic of Ireland, New Zealand and Australia, to consolidate complementary expertise, expand research boundaries, and develop joint capability. Our research exchange programme has three work packages, centred on the goal of improving knowledge about physical activity, diet and obesity and the impact of interventions aimed at improving population outcomes for these behaviours. Work Package 1 focuses on developing and validating new technologies to measure diet and physical activity behaviours. Work Package 2 focuses on modelling the impact of fiscal interventions on diet and nutrition and subsequent health outcomes in European, Australian and New Zealand (ANZ) populations. Work Package 3 focuses on developing a method for producing comparable estimates of the cost-effectiveness of policy and practice-relevant obesity interventions, including both individual treatment options and environmental change interventions. Above all, the programme will strengthen research links between European and ANZ partners to grow expertise and capacity in this important area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'STADY: Autonomous intelligent cleaning robot for stables' to be submitted under Horizon 2020.

assistant: **Abstract**

Founded in 2012 in Germany, Perpetual Mobile provides Mobile Application and consulting services in farm management and machinery control. Our 14 engineers, ICT and business managers have completed over 150 projects to date. Our familiarity with the market needs led us to develop new navigation technology called outside-in tracking (patented) that is the core of Zauberzeug™, a robot for the autonomous cleaning of stables. EU stables currently produce 1.38 million tonnes of manure annually that must be cleaned to avoid public health and pollution issues and comply with the Waste Framework Directive 2008/98/EC. Cleaning staff is difficult to source and expensive (around €27,500 per year). Current navigation technologies are based mainly on expensive GPS, LIDAR or Magnetic fields which allow navigation only outdoors or indoor and only over a limited variety of floor surfaces, preventing their use in livestock facilities or stables. However, the outside in tracking technology of Zauberzeug™ (combination of robot, a set of microprocessor cameras and a Mobile App) can automatically navigate both indoors and outdoors to detect, pick up and deposit objects (waste) with high precision. Our business model is also unique. Zauberzeug™ is offered for free, it has minimum installation and maintenance requirements (predictive maintenance). We will be the first movers offering advanced robotic Cleaning as a Service. Customers will acquire Zauberzeug™ free of charge and they will pay only for the cleaning service. This way we reduce the annual cleaning costs for stable owners (our customers) by up to 56%, while boosting our company growth. With a 250 units/year capacity by 2021, and a total potential market of stables having an area of 110Million square meters, our goal in the short ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Immune Cell Death Zonation Regulated by Protein Hubs in Plants' (ImmunoZoneHubs).

assistant: **Concept**

Agriculture, which underpins the livelihoods of over 2.5 billion people, is nowadays confronted with an array of new threats including plant pests. This project tackles the urgent need to develop new, technology-based sustainable strategies to combat the constant agricultural losses and economic drain derived from plant pests, which have been worsened because of climate change. The understanding of the molecular and cellular mechanisms underlaying plant pathogen interaction and defence responses is not only a fundamental scientific challenge, but it is also relevant to practical applications. Despite decades of research on host-pathogen interactions, knowledge on fundamental aspects of the plant immune system is still missing. This proposal provides an excellent opportunity to help filling this gap of knowledge as it targets the question of how cells translate molecular pathogen recognition into immune cell death, and how dying cells and their neighbours communicate to tightly control this process and ensure the proper balance in between defence responses and plant growth and fitness. To address this question, I have designed a multidisciplinary and international project using Arabidopsis thaliana plant as a model system to study the molecular determinants of plant immune cell death zonation and the involvement of plant metacaspases, distant relatives of animal caspases, in cell death. A plethora of techniques including molecular and biochemistry techniques, plant phenotyping and engineering, FACS and cell biology microscopy techniques will be used for the proper execution of this project. In addition to generate high-impact knowledge in plant immunity that will ultimately impact on society, this proposal will provide me with the expertise, resources, training, and netw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Responses of forest ecosystems and trees to global change.'.

assistant: **Objectives**

Forest ecosystem functions (tree growth and stand productivity biodiversity, soil fertility, carbon balance, water use) and tree physiology (symbiotic and pathogenic status, carbon and nitrogen budget, genetic diversity) in response to changing environmental conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Crashworthiness of joints in aluminium rail vehicles'.

assistant: **Innovation**

Aluminium alloys are now in widespread use in Europe and elsewhere for rail vehicle construction. However, in recent collisions involving seam welded aluminium rail coaches, observation showed that some of the longitudinal seam welds had fractured for some metres beyond the zone of severe damage, the panels themselves generally being intact without significant distortion. The designer needs the data to assess this fracture phenomenon and be able to take appropriate measures. In addition for this requirement, there is a need for innovation in the use of new joining techniques and joint design concepts to improve the performance of the vehicles under severe conditions. ALJOIN alms to prove innovative aluminium welding technologies in the construction of new rail vehicles such as friction stir welding (FSW). ALJOIN will study and evaluate the use of alternative grades of aluminium alloys to contribute to the crashworthiness of the rail vehicles.