RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards a neural field theory for spiking neuron networks with electrical synapses' (NeuralFieldTheoriES).

assistant: **Concept**

A major challenge in statistical physics, nonlinear dynamics and theoretical neuroscience over the last half century has been to understand the self-organizing principles governing the dynamics of large networks of neurons. Physicists and applied mathematicians have proposed simple mean-field descriptions of spatially-extended neural networks in terms of a relevant macroscopic observable, the firing rate. This approach has been particularly successful and so-called Neural Field Models (NFM) have become an extremely popular mathematical tool in neuroscience, physics and applied mathematics. Yet, to date, mean-field theories describe networks with chemical synapses, but it remains a major theoretical challenge to incorporate electrical synaptic interactions in such mathematical descriptions. Recently, a mean-field theory for large networks of spiking neurons has been proposed, which exactly links the dynamics of single neurons with that of two mean-field variables: The firing rate and the mean membrane potential. Remarkably, this theory permits to incorporate electrical interactions, but the mathematical derivation and the analysis of the dynamics of the first NFM is lagging. This project proposes the formal mathematical derivation of such NFM, as well as the thorough analysis of its dynamics and bifurcations. Towards this goal, at the host institution UPF in Barcelona, the ER will apply mean-field methods and nonlinear dynamical systems theory to derive the novel NFM (which we conjecture is of reaction-diffusion type). During a secondment at VU Amsterdam, the ER will be trained to become an expert in numerical analysis of partial differential equations, which will further allow him to perform extensive state-of-the-art computer simulations. The expected results will prov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'COnnected Media and Presence from European Institute of Technology' (COMPEIT) targeting Seventh Framework.

assistant: **Abstract**

COMPEIT creates a web-based system for highly interactive, personalised, shared media experiences. Research and development will link content-delivery networks with tools for enhancing mediated presence. COMPEIT takes the view that Internet-based distribution will transform traditional broadcasting towards higher levels of interactivity and integration with virtual, mixed and augmented reality, enabled by advanced web technologies and the proliferation of audio/video/tangible devices. The project addresses Quality of Experience in flexible, interactive media production and consumption systems designed for professional collaboration and shared leisure activities. It introduces the next step in interactive broadcasting systems by focusing technologies that enrich social connections, improve the feeling of being together in one shared space and enhance collaboration. Modular software will be developed based on low-cost, easily accessible web technologies (e.g HTML5, WebRTC, WebGL), leveraging on cloud based software access and distribution.<br/>Three key domains are identified for improving quality of experience:1) Spatial Connectedness2) Social Connectedness3) Information Connectedness<br/>COMPEIT develops and validates three key web services:a) Shared Experience with Tangible Interaction enables audiences to experience enhanced live media together,   complemented by tangible and interactive gamesb) A Broadcast Presence Studio to mix live media with various types of web-based contentc) Mixed-Reality Interaction, an advanced WebRTC-based service where content generated by the Broadcast Presence Studio service can be mixed into the viewer's physical environment using ambient devices.<br/>Prototypes will be validated in an Experience Lab and via an online media distribution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Adaptive decision support system for stormwater pollution control' to be submitted under Fifth Framework.

assistant: **Abstract**

The project aims at developing an adaptive decision support system (ADSS) for use by stakeholders involved in urban storm water management where decisions are made on many scales reflecting the spatial topology of urban catchments and the dynamic nature of urban development. The ADSS is a combination of simulation models, assessment tools, databases, guidance documents, road maps etc. Part of the research focuses on the functional behaviour of structural and non-structural best management practices (BMPs). Models will be developed for simulating pollution fluxes and assessing their possible source-elimination and fate in structural BMPs, and procedures for environmental risk assessment related to discharge of storm water priority pollutants to surface waters as well as urban soils and ground waters will be developed. The project is carried out by a multi-disciplinary research team and includes end-users and case studies in four European cities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transition of 2D-chemistry based supercapacitor electrode material from proof of concept to applications' (TRANS2DCHEM) targeting Horizon Europe.

assistant: **Abstract**

The world population is significantly increasing and its reliance on energy-based devices is higher than ever before. This leads to a continuous rise in global energy consumption. In addition, the ever-increasing demand for energy storage devices with improved performances and stability in securing safe operation of big data centers and networks for the ""internet of things"", transportation, grid storage, electronics in space applications and implanted medical devices is motivating the scientific community to develop new chemistries, compositions and morphologies of electrode materials in order to meet these challenges.Currently, rechargeable lithium-ion batteries, the most widely used electrochemical energy storage system of today, are still limited in terms of power densities and fire safety issues in many applications. Within the ERC-CoG 2D-CHEM and the subsequent ERC-PoC UP2DCHEM, the team of prof. Otyepka developed a nitrogen super-doped graphene electrode material (SC-GN3), with an unprecedented density. Supercapacitors (SC) made by SC-GN3 material can achieve up to 75 Wh/kg (200 Wh/L) energy density and show high-power density capability with potential up to 19 kW/kg (50 kW/L), twice higher than reference state of the art. Increasing the energy density of SC beyond 25Wh/kg will offer a paradigm shift in SC technologies allowing their wide application in electric vehicles and as support for batteries in power levelling and quick response devices for high power applications.The TRANS2DCHEM project intends to take this important field beyond its state-of-the-art, via the exploitation of the previously unexplored properties of the material, imparting top-rated performance in the respective energy storage devices. The proposal will bring the technology readiness of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Microbiology of Composting and other biodegradation processes' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

In Europe, composting is increasingly used as a recycling technology for organic wastes and considerable technological progress has been made in the past few years. However, despite the acknowledged importance of microbes in degradation processes, current new microbiological techniques have far too little been used for understanding biodegradation during composting. Knowledge on the composition and activities of compost microbial communities is largely based on traditional methods. The meeting will mainly focus on current research on microorganisms involved in the composting process, in possible improvements of process conditions, in the influence on end product qualities and on compost use in agriculture, forestry and horticuture.The scope of the meeting is to advance knowledge and understanding of microbial communities involved in the turnover of organic matter during biological waste treatment. Emphasis will be placed on new methods that allow a better resolution in time and space. The meeting aims at bringing together the best researchers in the field from all over the world, as well as producers, engineers and end users. Europe is, in composting technologies, leading in the world, and this meeting shall help to maintain the position, and probably enhance European competitively in this field of waste treatment.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00107-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The c-ret receptor tyrosine kinase as a target for drug discovery' (1998-2002).

assistant: **Concept**

The aim of this project is to generate a comprehensive platform of intellectual property to facilitate the discovery and development of a new generation of therapeutics with the ability to activate or inhibit the c-Ret receptor tyrosine kinase. Mutations in c-Ret are directly implicated in human cancers, and the c-Ret ligand, GDNF, is being developed as a therapeutic agent for neurodegenerative disorders such as Parkinson's disease and ALS. To develop c-Ret as a target for drug discovery we propose: i) to validate c-Ret as a drug target; ii) to develop scaleable assays for high throughput screening of c-Ret inhibitors and activators; iii) to isolate artificial c-Ret peptide ligands; iv) to determine the 3D structures of the extracellular and kinase domains of wild type and oncogenic c-Ret; v) to identify ligand binding sites in the c-Ret extracellular domain. Our long-term goal is to enter into license agreements with interested user groups for the exploitation of the generated knowledge and technology platform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Heterozygous expression of insulin in Nannochloropsis' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

As of 2024, more than 90% of the global insulin supply is controlled by just three conglomerates. Patents and license agreements restrict the use of optimised expression vehicles such as E. coli, S. cerevisiae, or P. pastoris, by the small/medium scale enterprises (SMEs) who can decentralise insulin production and cater to local demands. Project HERO (HEterozygous expRession of insulin in NannOchloropsis) aims to develop a novel microalgal platform technology for sustainable and accessible transgenic insulin production using Nannochloropsis oceanica as the model organism. The project builds upon the applicant’s recent discovery that N. oceanica (an ω-3 lipid rich, phototrophic microalgae) secretes the protease serine decarboxylase (SDC) during nitrogen scarcity. In this project, the transcriptome and secretome of N. oceanica under varying nitrogen concentrations will be comprehensively profiled after which, state-of-the-art plasmid designing techniques and CRISPR transformation pipelines will be used to insert the genes for insulin in the microalgal genome and express it as a fusion-protein with SDC. Controlled auto-proteolysis of the fusion-protein will greatly simplify and decrease steps in downstream insulin processing, thereby reducing overall water consumption and production costs. Moreover under nitrogen starvation, N. oceanica naturally over-produces high-value ω-3 lipids through biochemical pathways independent to SDC secretion. This offers the biorefinery benefits of multi-stream production (insulin and lipids) to further offset production costs. Finally, the engineered N. oceanica strain will be cultivated at pilot scale (100 L) to assess insulin yields, perform lifecycle analysis and establish its commercialisation potential.By empowering local SMEs to econom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Prototyping 'intime' - a NINAAT-based self testing platform to detect infectious diseases'.

assistant: **Innovation**

Presented here is the proposal for the project - Homecare test device ‚intime‘ – targeting to bring the first non-instrumented nucleic acid amplification test device onto the market. Market launch will start out with a device for the diagnosis and screening of the sexually transmitted infection Chlamydia trachomatis followed by a multifunctional device including additionally Neisseria gonorrhoeae and Trichomonas vaginalis. This project is the effort of an international consortium of highly professional partners to bring the modular ‚intime’ homecare diagnostic test from a functional model to the final prototype that is ready to be produced and brought to market. SelfD Technologie will lead this consortium and provide the technology for the device, which was already developed and proven to work in a laboratory setting. Now the homecare test will undergo final prototyping with the help of renowned design company wideblue and the experienced injection molding company Recon. This prototype will then be made in a small series production for a thorough analytical and clinical validation that will allow SelfD to apply for the CE mark and introduce the product shortly after the end of the project. The production will be achieved with Recon and the prepared chemical components necessary for the assay will be provided by Bioatlas, a company that SelfD is already engaged in a strategic partnership with. The clinical trial will be executed by the CRO proinnovera and their great experience and connections will ensure a smooth collection of all relevant data. In short, the ‚intime‘ project will propel the novel diagnostic tool for home use onto the market and thus improve healthcare and allow SelfD to launch their first product and position itself as a promising IVD developer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced nanophotonic point-of-care analysis device for fast and early diagnosis of cardiovascular diseases' under Horizon 2020.

assistant: **Concept**

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). The diagnosis will be carried out by means of the fast (<10 minutes), ultra-sensitive (<1 ng/L) and label-free detection of multiple cardiac biomarkers, using a small volume of whole blood (<100 μL). This POCT analysis device will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates.The PHOCNOSIS analysis device will be based on two state-of-the-art technological elements in order to obtain a compact and highly sensitive final device. First, an integrated micro-/nanofluidic system will be used for biomarkers separation, purification and concentration, targeting an effective concentration increase by a factor greater than 1000x for the targeted biomarkers. Then, the concentrated biomarkers will be detected using a novel nanophotonic-based sensing technique, envisaging a final combined detection limit below 1 ng/L. This novel sensing technique allows us to obtain systems which are low-cost, compact and with a lower complexity, thus making them suitable for the development of portable devices for POCT. The PHOCNOSIS project will target the deployment of disposable biochips with an envisaged cost below €3 to be used in a handheld analysis device with an envisaged cost below €3000.Special attention will be paid within the PHOCNOSIS project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Project for improving a competitive wine-process in accordance with the new economy's marketing tools' (1998-2002).

assistant: **Concept**

The proposed project is based on an integral strategy involving other EU&Ass.countries 'Sees, both to upgrade the C.O.D. (controlled origin denomination) quality white-wine and to market by means of new economy's tools, at the international level. This initiative regards a series of components: (I) health and nutrition linked with the phenol compounds, (ii) the historical images involving the wine to the EU landscapes and traditional dishes, (iii) E-commerce for wide-wide market. During the Exam the promoter intends to enlarge the Craft partnership at a collaborative group of 5 members. The project's most significant research concerns the quality of the white-wine strengthening the substances responsible of the recently discovered benefits on the human health (flavonoidpoliphenols). Furthermore the project intends to emphasize the wine as culture &tradition bound with each C.O.D vineyard. This historical aspect is the seal-of-quality that could be only shown by the EU vineyard, under the label: Culture&Wine in the western civilisation. The project will have support of thee-programme PRIMAVERA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combined Multi-marker Screening and Randomised Patient Treatment with Aspirin for Evidence-based Pre-eclampsia Prevention' (ASPRE), addressing dissemination and exploitation.

assistant: **Impact**

Project ASPRE is a commercially led development project that aims to boost translation of the results of PREGENESYS (FP6 EU #37244) into effective applications for prenatal care. PREGENESYS has identified several biomarkers for early (11-13 weeks’ gestation) and effective identification of pregnancies at high risk of developing pre-eclampsia (PE). This disorder affects 2-8% of pregnant women and is a major cause of short- and long-term maternal and perinatal morbidity and mortality. Studies under PREGENESYS using in-vitro research methods suggested that aspirin is the most promising agent for preventing PE. Evidence from small clinical studies has indicated that prophylactic use of low-dose aspirin starting before 16 weeks’ gestation can potentially halve the PE prevalence and its associated complications. Objectives: Widespread clinical implementation of a strategy of screening and prevention of PE: (1) Reduce the prevalence of PE requiring delivery before 37 weeks (preterm PE) by at least 50%, (2) Demonstrate through a large multicentre screening and prevention study the acceptability, uptake and efficacy of first trimester multi-parameter screening of preterm PE and its preventative treatment with aspirin, (3) Develop affordable, automated and reliable methods for high throughput measurement of biomarkers and commercial platforms for PE risk assessment software, (4) Develop management protocols for high risk and low risk pregnancies for PE, (5) Improve education and training of healthcare professionals involved in pregnancy care, (6) Conduct the dissemination and training required to drive clinical acceptance and adoption of multi-parameter PE screening and aspirin treatment. Expected results and impact: Generating a market demand for SME-based newly developed produc