RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Prevention of asbestos-related diseases in Hungary, Estonia and Kar elian Republic of the Russian Federation' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Foreseen ResultsThe impact of this project include the significant reduction of asbestos-related diseases in the future as well as the preservation of human resources and scientific knowledge that have been acquired over the years in the participating CCE/NIS countries.This project aims to improve the safety in the use of asbestos, to evaluate the extent of health risks and to establish diagnostic criteria for asbestos-related diseases in three CCE/NIS countries. The proposed joint research of the six leading national institutes supports directly several technical, medical and administrative actions of prevention. Monitoring and inspection activities are strengthened as well as general awareness of the health risks associated with asbestos at workplaces and in the environment.A total of 300 buildings are inspected for asbestos-containing materials in Budapest, Tallinn and Pedrozavodsk. The methods of sampling and analysis are introduced by training courses and practical exercises. As a result, the participating experts can draft national guidelines for appropriate safety measures according to EU regulations and practices.During two years, a series of 500 lung cancer cases will be interviewed for smoking habits, work history and asbestos exposure. Altogether 50 lung tissue samples will be collected from these three areas, analyzed by electron microscopy and compared with reference values in respect to mineral type and level of asbestos fibers. The lobar distribution of tumor origin will be used as another independent measure of probable exposure to asbestos. Expectedly, about 10 to 20 pleural or peritoneal mesotheliomas are found during the clinical examinations. The mesothelioma diagnoses will be verified and its annual incidence can serve as an indicator of asbestos ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'EXSOLUTION-BASED NANOPARTICLES FOR LOWEST COST GREEN HYDROGEN VIA ELECTROLYSIS'.

assistant: **Objectives**

Today’s alkaline electrolysers favour current densities over efficiency: to achieve commercially relevant current densities, these systems typically operate at voltages exceeding 2 V/cell, corresponding to electrolyser power consumption of >54 kWh/kg. There are four reasons for employing high voltages: 1) electrodes’ insufficient electrochemical activity, 2) the relatively high gas permeability of commonly employed diaphragms means that improved hydrogen purity can be achieved at high current operation points, 3) the stack designs are not optimised for low-current operation due to very simple flow fields, and 4) high currents are required to achieve attractive electrolyser CAPEX costs (EUR/kW). Yet, there is a growing consensus that the wider adoption of green H2 is not hindered by electrolyser CAPEX: the costs of green H2 are in most cases vastly dominated by OPEX, which in turn is a direct function of electrolyser efficiency. Thus, to achieve lowest possible levelised cost of H2, efficiency should be prioritised over current density.EXSOTHyC will optimise electrolyser operation towards lower voltages and higher efficiencies. The innovation is three-fold and addressing all four above-mentioned reasons:•Alternative pathways to the O2 and H2 evolution reactions by new anode and cathode approaches•Novel concepts of membrane electrode assemblies with integrated components •Novel cell design to enhance overall cell efficiency by integrating disruptive conceptsIn the project, we adopt an approach combining computer simulations, rapid prototyping, and thorough experimental validation on single cell, SRU and short stack level. In a nutshell, we will combine electrodes made using powder metallurgy with ceramic nanoparticles fabricated by exsolution, leveraging on the synergy th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Socs3 gene in oocyte maturation and fertilisation - a novel link between inflammation and infertility' under Horizon 2020.

assistant: **Concept**

Increasing maternal age, a prevalent trend in developed countries, negatively influences oocyte quality and consequently female fertility – 5% of all couples experience fertility problems arising from a physiological source in the women. To develop novel approaches to prevent or treat infertility, a more complete understanding of oogenesis is required. The host laboratory has recently identified the Socs3 gene, to date associated only with roles in the immune system, as a novel strong candidate regulating oogenesis. The project exploits a genetic approach to ablate the Socs3 gene from the female germ-line and addresses the role of Socs3 gene during mouse oocyte maturation and fertilisation, e.g. in correct chromosomal segregation, followed by further detailed and cutting-edge functional characterisation. The results could lead to the identification of novel therapeutic targets to treat female infertility. Dr. Veselovska, coming from a world-renown institute, is joining a well-established early mammalian development orientated host group, within the Department of Molecular Biology at the University of South Bohemia. Synergies arising from this multidisciplinary proposal will benefit both host and applicant. In particular, Dr. Veselovska is bringing a wealth of highly relevant mouse oocyte experience and bioinformatics skills for genome-scale analyses that are currently an underrepresented skills set in the host laboratory and host institution, as well as her network of UK based collaborators. She will receive training that is both complementary to her current knowledge and skills and novel and highly contemporary in relation to the experimental approaches used. Consequently, the fellowship award will substantially further the Dr. Veselovska’s career ambitions to become a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effective quantum cosmology and dark matter' (COSMODYN) targeting Sixth Framework.

assistant: **Abstract**

It is proposed to search for observable cosmological signatures of quantum field theoretic effects, which originated during the very early universe. In flat space, the energy-time uncertainty principle allows virtual particles to exist for only very brief periods.The expansion of space-time relaxes this constraint by diluting the kinetic energy of virtual particles. If such a particle has no mass energy, and if the expansion dilutes its kinetic energy sufficiently rapidly, then the particle can exist forever. Particles, which are mass less and also lack conformal invariance -- such as gravitons and minimally coupled scalars -- are produced copiously during inflation. This process is believed to be responsible for the anisotropies now observed in the cosmic microwave background radiation.Mass-less particles also mediate long-range interactions and this suggests a wide range of potentially observable effects arising from interactions between the particles produced during inflation. The essential tool in any study of these effects is the Schwinger-Keldysh formalism. The project will also focus on dark matter phenomenology and gravitational lensing, which will be useful in recognizing and quantifying observable signatures. In addition to its immediate and substantial scientific impact, the project can develop into a long-term collaboration in a region of great potential importance to Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Epigenetic regulation of Alzheimer's disease related genes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Alzheimer’s disease (AD) and other dementias affect over 7 million individuals in Europe. There is, as yet, no treatment to halt or reverse disease progression despite huge investments into research. The accumulation of the amyloid beta-peptide (Abeta), derived from the amyloid precursor protein (APP) in the brain, is a key factor in the development of AD but the roles of other APP metabolites are poorly understood. This project will focus on one of these metabolites, its intracellular domain, AICD, and the mechanism for its nuclear trafficking and gene transcriptional regulation, especially of the Abeta-degrading enzyme, neprilysin (NEP), which maintains Abeta homeostasis. These studies will focus on the differential contributions of the three APP isoforms to AICD production, nuclear trafficking and gene regulation, and will use a variety of neuronal and non-neuronal models to analyse epigenetic changes mediating NEP expression including chromatin composition of the NEP gene in active and downregulated states and whether APP isoform effects are direct or indirect. In parallel, other putative AICD-responsive genes will be compared (aquaporin, GSK-3beta). This will allow us to formulate strategies for up-regulation of key neuroprotective genes in disease leading to potential new therapeutic approaches. The project will provide the Research Fellow with broad experience in molecular neuroscience (from bioimaging and protein trafficking to chromatin analysis and gene regulation) in a well-founded, integrated and multi-disciplinary environment for AD research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Road Pavements & Bridge Deck Health Monitoring/Early Warning Using Advanced Inspection Technologies' in the context of a Seventh Framework call.

assistant: **Objectives**

The European Road Network is undoubtedly one of the most important land infrastructures in the EU. It is and will remain for the foreseeable future a crucial artery for Europe, both in economic terms, as it services the vast majority of goods traffic, and in social terms, as it does so for passenger travel as well.Maintenance is considered to be the most expensive function of a high-way operating agency, so there is a special need for the early detection of deterioration mechanisms and of potential presence of defects through a more advanced road pavements inspection technology.The proposed system will detect the presence of defects, determine the cause, extent and rate of deterioration, provide information for assessing stability and serviceability and for evaluating the cost-effectiveness of various remedial measures and provide this information in real time, not causing traffic disturbances.The system is aiming to upgrade and optimize the inspection & maintenance of the European roads, reducing costs and increasing traffic safety and will achieve this by developing a novel automated and integrated NDT (Non Destructive Techniques) system for high speed analysis and evaluation. It will demonstrate the value of combining 3 technologies: Ground Penetrating Radar, InfraRed Thermography and Air Coupled Ultrasonic testing with Near Real-Time data transfer and analysis as a reliable, fast and safe tool for pavement inspections, as well as a great business opportunity for SME participants in EU. The proposed system incorporates and drastically enhances the capacities of the traditional NDT techniques, to produce quantitative, reliable, precise, continuous and at-traffic-speed measurements for the assessment of structural pavement condition. Research & innovation outcomes will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Stochlneq' (1998-2002).

assistant: **Concept**

Stochastic inequalities constitute a fundamental building block of Probability Theory. On the other hand, they form a major thread within and between various sub-areas of Probability and Statistics. Examples of such inequalities that have experienced a recent development and have produced an impact on different areas are the following ones:- Concentration and deviation inequalities for various types of stochastic processes. The recent breakthrough of Talagrand showing that the supremum of an empirical process concentrates about its mean with very large probability has been applied in many areas of Statistics, like model selection, density estimation and survival analysis.- Estimation of the p norms of sums of independent random variables in terms of the individual distributions of the summands. - Inequalities in Malliavin calculus and its applications to density estimates and to estimates for anticipating integrals. - Geometric inequalities for log-concave probability measures. The recent progress in the correlation inequality for Gaussian measures has been applied to the computation of Onsager-Machlup functionals for solutions of stochastic partial differential equations and diffusion processes. - Further advances in martingale inequalities have been applied to the geometry of Banach spaces and decoupling inequalities have been successfully applied in the asymptotic theory of U-statistics and multilinear forms.This conference will provide a unique opportunity for collaboration and exchange of ideas between probabilists working in stochastic inequalities and other researchers that are using estimates based on stochastic inequalities in different fields of Probability Theory and Statistics. In particular space will be provided in the afternoon sessions for less establish
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding Hedgehog signalling in breast cancer and mammary gland stem cells using tissue specific expression of Gli1 the main effector of the Hedgehog pathway' (MAMMAHOGLGR), addressing dissemination and exploitation.

assistant: **Impact**

Only a subset of tumour cells is capable of giving rise to new tumours. These so called “tumour stem-cells” are functionally similar to adult stem cells and have been identified in tumours of several tissues. Whether transformation of adult stem cells into tumour stem cells is the event leading to the disease is not clear. Alternatively, tumours could arise from the population of committed progenitors, which have de novo acquired self-renewal properties. The aim of the proposed project is to investigate the role of Hedgehog (Hh) signalling in mammary gland stem/progenitor cell fate and cancer development. The following questions will be addressed: 1. Does induction of Gli1 expression expand the stem/progenitor cell population in the mammary gland and are the functional properties of these cells changed? 2. Does induction of Gli1 expression expand the population of Lgr5+ cells in Gli expressing mammary glands and Gli1 induced tumours? 3. Does induction of Gli1 expression result in additional genetic changes relevant for tumour formation? 4. Does induction of Hh-signalling in Lgr5+ mammary cells cause tumour formation? 5. Would prevention of Gli activation with small molecule inhibitors like GANT61 prevent mammary cancer formation? The activity of the Hh pathway is required for growth of a variety of tumours, including breast cancer. We propose to use tetracycline-controlled conditional expression of Gli1, the main effector of the Hh-signalling pathway, in mouse mammary gland as a model system. The dynamic changes in the stem/progenitor cell population will be monitored after induction of Gli1 expression. Stem cells will be sorted based on known markers, including the orphan G protein coupled receptor Lgr5. The role of Hh signalling in Lgr5+ cells and the tumorigenecity o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dynamics and Morphogenesis of Branching Structures, from Cells to River Networks' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

While the study of morphogenesis has a long and fascinating history, pattern formation of complex structures has received a deeper attention in the last twenty years. In many fields, including developmental biology, out-of-equilibrium physics and differential geometry, concepts and models have been put forward that pave the way to a description of the mechanisms of morphogenesis. Among the possible structures that arise spontaneously in nature, there exist different classes. The class of branching structures is ubiquitous, and one of the most general. It is found at all scales, from molecular dendromeres to river bassins, and it incorporates such important and diverse structures as glands, vascular networks or neurons in the biological realm, and dendrites, cracks or dielectric sparks in physics.While all these systems may seem to belong to different worlds, it appears from closer inspection that similar if not identical concepts have been elaborated independently by different communities in order to describe or model their growth. Recent important progress in the different fields evoked above makes it useful to gather scientists of the different communities, in order to give a synthetical and up-to-date knowledge of the present scientific state of these questions. The summer school of Les Houches, with its long outstanding tradition for supporting new emerging fields is an excellent place to give an impulse to the field of branching morphogenesis. Specialized courses, on Neurons, Vascular systems, Gland growth, Dendritic growth, Mathematical and Physical models and Geology will be given at a high scientific level but with a special attention towards different communities, which are not expert in these fields. Also, more general courses will give an overview of why and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Genetic Record of Atmospheric Carbon dioxidE (GRACE)'.

assistant: **Concept**

Two key variables, temperature and atmospheric carbon dioxide (pCO2), define the sensitivity of the Earth’s climate system. The geological record provides our only evidence of the past climate sensitivity of the Earth system, but there is no direct quantitative measure of pCO2 or temperature beyond the 650 kyr extent of the Antarctic ice cores. The reconstruction of past climate, on timescales of millions of years, relies on the analysis of chemical or isotopic proxies in preserved shells or organic matter. Such indirect approaches depend upon empirical calibration in modern species, without understanding the biological mechanisms that underpin the incorporation of the climate signal. The intention of this ERC grant proposal is to establish a research team to investigate the “living geological record” to address this major gap in climate research. I hypothesise that direct climate signals of the past are harboured within, and can ultimately be deciphered from, the genetic make up of extant organisms. Specifically, I propose an innovative approach to the constraint of the evolution of atmospheric pCO2 during the Cenozoic. The approach is based on the statistical signal of positive selection of adaptation within the genetic sequences of marine algal Rubisco, the notoriously inefficient enzyme responsible for photosynthetic carbon fixation, but supplemented by analysis of allied carbon concentrating mechanisms. As a calibration, I will characterise the biochemical properties of Rubisco in terms of specificity for pCO2, isotopic fractionation and kinetics, from a range of marine phytoplankton. The prime motivation is a history of pCO2, but the project will yield additional insight into the feedback between phytoplankton and climate, the carbon isotopic signatures of the geo