RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multi-Owner data Sharing for Analytics and Integration respecting Confidentiality and Owner control' (MOSAICrOWN).

assistant: **Innovation**

The application of data analysis techniques over large data collections provides great benefits, from the personal, to the business, research, and social domain. The availability of large data collections recording actions and choices of individuals and organisations can lead to great improvement in the understanding of how the world operates. The continuous evolution of ICT is enabling the realisation of such vision at a fast pace, supporting the realisation of architectures enabling collaborative data sharing and analytics. A clear obstacle towards the realisation of such potential and vision is represented by security and privacy concerns. Indeed, the (actual or perceived) loss of control over data and potential compromise of their confidentiality can have a strong detrimental impact on the realisation of an open framework for enabling the sharing of data from multiple independent data owners.  The goal of MOSAICrOWN is to enable data sharing and collaborative analytics in multi-owner scenarios in a privacy-preserving way, ensuring proper protection of private/sensitive/confidential information. MOSAICrOWN will provide effective and deployable solutions allowing data owners to maintain control on the data sharing process, enabling selective and sanitised disclosure providing for efficient and scalable privacy-aware collaborative computations. MOSAICrOWN Consortium sees the participation of major industry players, providing strategic use cases with strong exploitation and impact, and of an SME supporting deployment and standardisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Growth poles in the metropolitan periphery and sustainable development' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Issues of sustainability of urban structures and urban development are of great importance in applied urban research. The research group cities and urban regions" has a sound basis in the theoretic and empirical analysis of urban problems. In order to develop into a centre of competence for the urban periphery it seems necessary to include applied aspects into the research agenda. There is also a growing interest in issues of peripheral growth especially in cities in Central and Eastern Europe. The institute would be in an excellent position to co-operate with Eastern European partners. A combination of theoretical, empirical an applied research aspect would produce significant synergy Effects."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Imaging mass spectrometry for nanoscale mapping of biological cells and tissues'.

assistant: **Concept**

The objective of this project is to develop new techniques for sub-micrometer-resolved, chemical 3D- mapping of substances in single cells and organised tissues. The techniques will be based on time-of-flight secondary ion mass spectrometry (TOF-SIMS) and laser secondary neutral mass spectrometry (Laser-SNMS), providing simultaneous identification, localization and co-localization of a variety of substances (lipids, peptides, proteins, drugs and metabolites) without the need for pre-selected molecular labelling. The proposed technology constitutes a significant step beyond current methods for chemical analysis of cell and tissue samples, which can only provide either non-local information of the chemical composition or local information of a few pre-selected substances. To meet the minute quantities of sample substance present in the small volumes to be analysed, the detection sensitivities will be considerably improved relative to current conventional technology. By taking advantage of recent progress in(i) sample preparation techniques,(ii) instrumentation, and(iii) data interpretation methods, and by pushing this development further, the required sensitivities and lateral resolutions below 50 nm will be achieved. Methods for 2D mapping at different depth levels, providing 3D chemical analysis, will also be developed. The proposed techniques will lead to breakthrough discoveries and applications in several fields of research and technology, such as fundamental biology, clinical diagnostics, pharmaceutical R&D, nanobiotechnology, and food and environmental impact on health. The project will place Europe in a world leading position in the area of imaging mass spectrometry in biosciences. The present project does not fit into any of the thematic priority areas alone but,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Asymmetric Organocatalytic Fluorination with fluoride salts' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Fluorine is a key element in modern pharmaceutical, agrochemicals and anesthetics. It is well-known that fluorine substitution can strongly improve drug efficiency by modifying the properties of compounds such as lipophilicity, metabolic stability, bioavailability and protein binding affinity. The selective installation of fluorine into molecules, especially in a catalytic way, still represents a major challenge for organic synthesis. To date, chemists have developed a range of transformations for carbon-fluorine bond formation yet the vast majority employs fluorine sources derived from F2, a highly toxic and corrosive gas. Only few processes involve the use of cheaper fluoride salts but often require expensive transition metals and suffer from a limited scope. With this proposal, we envision the development of a novel asymmetric metal-free catalytic reaction for carbon-fluorine bond formation by employing cost effective fluoride salts. The organocatalytic process we have designed is mechanistically unprecedented and will be applied to the synthesis of enantiopure fluoroamines which have a direct application in medicinal chemistry. This novel methodology will therefore provide a novel toolbox of reactions for chemists both from academia and industry and has the potential to have a strong impact on society by improving diagnostics, patient care and health-related quality of life.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Resource-efficient sulphur-free production of cellulose pulp'.

assistant: **Innovation**

The Nova Cell process is a new resource and eco-efficient sulphur free concept for manufacturing of chemical pulp. The proposed European project will develop a solid techno-economical platform for an implementation of the Nova Cell process into the European chemical pulp industry. Recent discoveries in pulping catalysis and oxygen dezincification form the scientific and technological basis for the project. The elimination of sulphur creates a new odourless image for the industry; simplify effluent recycle and by-product valorisation. The Nova Cell process uses conventional machinery, which will greatly facilitate introduction of the process into existing pulp mills. A strong consortium will ensure that the project objectives will be met for the benefit of the European pulp and paper industry, fibre consumers and European citizens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Presidency Conference on the Future of Life Sciences' to be submitted under Horizon Europe.

assistant: **Abstract**

On the first of January 2023, Sweden took over the Presidency of the Council of the European Union. One prioritised area for Sweden and the EU that will be addressed is the future of life sciences, and more specifically the implementation of precision health. To this end, a presidency conference will be held in Stockholm on this topic on 26-27 June 2023. The conference is hosted by the Swedish Government and the objective is to provide a forum for knowledge exchange on how to utilize the opportunities that precision health brings in modernizing our healthcare. The purpose of the conference is  to inspire change and to identify needs for continued development of precision health through research and innovation.  The conference is also a means of creating conditions for fruitful collaborations within the European union. Four Government agencies with expertise in regulatory affairs, eHealth, ethical approval and innovation, respectively are engaged in preparing and hosting specific parts of the conference programme. The main theme of the conference is precision health  opportunities and challenges ahead. Specific areas that will be addressed are data-driven implementation, ethics, precision prevention and regulatory procedures. Patient participation as well as sustainability will be transversal perspectives throughout the programme.The conference will be held in Stockholm, Sweden, at Karolinska Institutet, one of EUs top ranked medical universities. Karolinska Institutet is situated in the heart of the new life sciences district which also includes one of EUs top ranked hospitals, an increasing number of headquarters and R&D facilities of big and small life science industries, major national research infrastructures and more.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Apoptotic foci: composition, structure and dynamics' under Horizon 2020.

assistant: **Concept**

Apoptotic cell death is essential for development, immune function or tissue homeostasis, and it is often deregulated in disease. Mitochondrial outer membrane permeabilization (MOMP) is central for apoptosis execution and plays a key role in its inflammatory outcome. Knowing the architecture of the macromolecular machineries mediating MOMP is crucial for understanding their function and for the clinical use of apoptosis.Our recent work reveals that Bax and Bak dimers form distinct line, arc and ring assemblies at specific apoptotic foci to mediate MOMP. However, the molecular structure and mechanisms controlling the spatiotemporal formation and range of action of the apoptotic foci are missing. To address this fundamental gap in our knowledge, we aim to unravel the composition, dynamics and structure of apoptotic foci and to understand how they are integrated to orchestrate function. We will reach this goal by building on our expertise in cell death and cutting-edge imaging and by developing a new analytical pipeline to:1) Identify the composition of apoptotic foci using in situ proximity-dependent labeling and extraction of near-native Bax/Bak membrane complexes coupled to mass spectrometry.2) Define their contribution to apoptosis and its immunogenicity and establish their assembly dynamics to correlate it with apoptosis progression by live cell imaging.3) Determine the stoichiometry and structural organization of the apoptotic foci by combining single molecule fluorescence and advanced electron microscopies.This multidisciplinary approach offers high chances to solve the long-standing question of how Bax and Bak mediate MOMP. APOSITE will provide textbook knowledge of the mitochondrial contribution to cell death and inflammation. The implementation of this new analyt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Enunciative Devices of the European Francophone Essay Film'.

assistant: **Objectives**

This challenging and ambitious research project aims to analyse the enunciative devices of the European francophone essay film in order to determine the audiovisual procedures that materialise the expression of subjectivity, the thinking process and self-reflexiveness, which define this stimulating filmic form. Starting from the concept of francophony, and through an innovative interdisciplinary and intermedial approach that relates cinema to philosophy, semiotics to aesthetics and cinema history to cultural and gender studies, the research will establish firstly a typology of the different enunciative devices: audiovisual materials, intermedial forms and filmic procedures. Secondly, the research will analyse the relationship between them and the themes addressed by the essay films and the artistic movements they belong to, since its birth in modern cinema to the very present, in which this essayistic practice has known a great proliferation due to the digital revolution, facilitating the experience of subjectivity and intimacy of this filmic form. Thirdly, the research will determine the functionality of the different enunciative devices, exploring how identity –individual, social, political, gender, artistic– thinks through cinema. The EDEF proposal, considering the essay film as a social, political and artistic developer that fosters society’s critical thinking, will also analyse the function of the spectator in this dialogic filmic form. The project includes a dissemination plan and a communication strategy that will ensure the spread of the research results to both the widest scientific community and the largest general public, following the guidelines of the fully open-access policy of Horizon 2020. The principal output will be a scholarly monograph with a prestig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Stress minimization on deep sub-micron CMOS processes, measured by a high spatial resolution technique, and its application to 0.15 micron non volatile memories' (STREAM), addressing dissemination and exploitation.

assistant: **Impact**

This project deals with one of the major issues of concern for the deep submicron CMOS technology, namely the mechanical stresses built up in the layers and substrate during processing. STREAM aims at the routine determination of stress in the 0.15m generation of non volatile memories by the convergent beam diffraction technique of transmission electron microscopy (TEM/CBED) with a spatial resolution down to 1 nm; this will be achieved by the development of a software package, which will digitally acquire the diffraction patterns and yield the strain tensor in the corresponding nanoregions of the structure. This stress information in silicon will help improving the existing stress simulation models. These upgraded models will be used to set up the feedback to modify the technological process flow of the 0.15m CMOS, in order to minimize the stress.* Implementation and integration of all the components that are part of the Hope reference architecture into the final prototype of the HOPE system* Production of the final prototype of the Course Content Material, which has been integrated in the System Prototype* Following the Trial specifications, which have provided the necessary infrastructure for the operation of the trials, we have proceeded with the evaluation and validation of the system. This also implied the definition of the specific evaluation criteria and the installation of the Hope system at each of the three pilot sites (located one in Spain and two in Greece)*Real users (young prisoners) in the pilot sites have tested the final prototype. Validation reports have been produced based on questionnaires and interviews made to the users of the system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Transcriptional Engineering of Hematopoietic Stem Cells using CRISPR'.

assistant: **Innovation**

Hematopoietic stem cells (HSCs) reside in the bone marrow where they throughout life sustain continuous blood production through a controlled balance of differentiation and self-renewal. Transplantation of HSCs from a healthy person can replace a defective hematopoietic system of a patient thereby curing the patient for life. HSCs have found increasing therapeutic application, e.g. in hematologic malignancies and hematopoietic genetic disorders. This applies not only to the allogeneic transplantation setting but also to the autologous setting where advances in genetic engineering technologies have enabled autologous gene therapies. However, major challenges remain in both settings pertaining to the scarcity of HSCs, as well as the cells being partially refractory to precise gene correction.In this research proposal, I will address these challenges by leveraging the unique power of repurposed CRISPR/Cas systems for precise transcriptional manipulation of HSCs. In these systems, the normal DNA-cleaving ability of the Cas9 enzyme is disabled (dCas9) while transcriptional activators or inhibitors are fused to dCas9. By targeting the dCas9-effector proteins to transcriptional start site regions by sgRNA programming, gene transcription can be activated (CRISPRa) or inhibited (CRISPRi). Complex transcriptional engineering is readily achieved using multiple sgRNAs and orthogonal CRISPR systems for simultaneous CRISPRa and CRISPRi.I will apply these technologies to investigate and enhance therapeutically relevant HSC pathways, namely homologous recombination for precise gene editing, self-renewal, and bone marrow homing. These biological phenomena have previously been studied with techniques that do not have the same elegant properties and therapeutic relevance as CRISPRa/i. Wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Life-long cross-generational priming of the hypothalamus for obesity' (FOODFORLIFE).

assistant: **Innovation**

Evolutionary success drives continuous human adaptation. A pervasive challenge is the substantial change in the composition and nutritional value of diets available. This is particularly relevant for child-bearing women because metabolic bias through diet composition can adversely affects pregnancy outcomes. Even though clinical and experimental studies correlate maternal obesity during pregnancy (affecting ~30% world-wide) with congenital metabolic illnesses, a causal relationship between maternal obesity, impairment in neuroendocrine development and ensuing deficits in metabolic control of affected offspring is as yet missing. The hypothalamus is the neuroendocrine interface linking the brain and periphery. Thus, we hypothesize that maternal obesity could evoke permanent molecular changes in hypothalamic neurons of the offspring to compromise their plasticity and adaptive repertoire. This notion is on the backdrop of our recent success in defining, by singe-cell RNA-seq and brain-wide imaging, the developmental trajectory of neurons that build the mammalian hypothalamus, and in discovering the function of novel neuronal subtypes. Here, we will determine molecular, cellular and network-level changes in the hypothalamus of offspring born to obese mothers. We will combine single-cell RNA-seq and ATAC-seq in the same neurons to precisely catalogue permanent modifications to gene expression at successive developmental stages in mice. We will particularly interrogate molecular determinants that can impair the neuronal circuitry controlling food intake, including leptin and endocannabinoid interplay as a candidate. We will complement these data by identifying novel cellular sites of hormone secretion that shape brain and bodily architecture and are sensitive to maternal obes