RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Transcription Factor-mediated Neuronal Cell Fate Programming in Human Stem Cells' in the context of a Horizon 2020 call.

assistant: **Objectives**

The discovery of pluripotent stem cells has expanded the working modes in biology towards the reverse engineering of specific cell types. Unlike studying developmental phenomena in vivo, we are now theoretically able to mimic some of these processes in a dish. The use of human induced pluripotent stem (iPS) cells facilitates studying the genesis of human cell types in an ethically approved setting. However, exploiting the full potency of stem cells is only possible with very few differentiated cell types. In particular, the generation of neurons is in its infancy: of the many neuronal types present in the brain, only a few types have been generated in vitro. So far, neuronal differentiation protocols are multifaceted and tailored to individual cell types. The molecular events that occur during reprogramming remain enigmatic. Hence, we cannot confer these protocols easily on producing different neurons of interest. Therefore, we plan to induce transcription factors as differentiation control buttons in human iPS cells in order to explore in vitro neurogenesis systematically. First, we will apply a human transcription factor library to conditional fluorescent iPS reporter lines, facilitating high-throughput isolation and analysis of induced neurons. Second, the underlying gene regulatory networks will be revealed using RNA-sequencing over the entire differentiation period to identify the biological rules of in vitro neuronal differentiation. We will combine these in-depth transcriptomic analyses with morphological, anatomical, and functional characterizations. Finally, based on our discoveries, we will engineer human photoreceptors that can be applied to cell transplantation experiments in retinal degeneration diseases. Conceptually, our approach paves the way for targete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Trust-by-Design – Strong Security Arguments for Symmetric Key Cryptography' (SymTrust) targeting Horizon Europe.

assistant: **Abstract**

Symmetric cryptographic primitives protect a large percentage of today's data, whether in transit or storage. This trend is going to increase even more in the future. Consequently, new domain-specific ciphers are needed with significant performance benefits for areas such as memory-encryption, multi-party computation, or crypto-currencies. Great progress has been made regarding their performance. Less progress has been made for security arguments that seek to proof their resilience against malignant attacks. Indeed, most of the security analysis we apply for symmetric ciphers is based on false assumptions and most attacks trying to break those ciphers are flawed. As a consequence, it takes several years to build the necessary trust in the security of any new symmetric cryptographic primitives to be deployed and used.  In times of fast innovation cycles where emerging applications are in constant need for new tailored symmetric cryptographic solutions those slow design cycles of symmetric cryptographic primitives are prohibitive and have to be shortened. Within the project, I plan to enable stronger security arguments and tool-based bounds on key-recovery approaches which will accelerate the design process. This will open the path to a new design strategy of trustworthy by design ciphers and contribute to ready-to-use and highly-secure symmetric cryptography suitable to satisfy the needs of future applications.To this end, I will •analyze fundamental properties of symmetric cryptographic primitives especially related to their representation,•derive modular security arguments, •develop a software-assisted approach to optimize and verify the key-recovery part of attacks,•design an efficient cache-encryption algorithm to exemplify the potential of the new design framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Solving Water Issues for CSP Plants'.

assistant: **Innovation**

SOLWARIS targets to significantly reduce the water used by CSP plants (by 35% for wet cooled & by 90% for dry cooled). The project proposes to demonstrate the efficiency of innovations on solar field cleaning, power-block cooling, water recycling system, and plant operation strategy. Among these are solutions to reduce solar field water cleaning needs, an operation and maintenance optimizer software including soiling forecaster, a MEE water recovery technology running on otherwise dumped heat from the solar field, and a cooling concept for the turbine condenser storing excess heat when ambient is too warm, then releasing it during cool night times.The solutions will be implemented at two CSP operational sites, “La Africana” parabolic trough plant in Spain and “Ashalim” central receiver plant in Israel, to demonstrate significant reduction in water use while making CSP more cost effective, and achieving near-to-market status. The solutions are best applied together, but each will also bring water and cost savings on its own, thanks to their ability to fit any kind of CSP plant; dry, wet, or hybrid cooled, existing or future ones, tailored to location and policy framework. Their application will save more than 0.5 M€/year of operational cost for a 50 MW CSP plant. Regarding competition on water resources and humanitarian issues, the social acceptance of CSP will be increased by detailed analysis of case studies and education of local population to the benefits of solar energy. The targeted savings of water and operation costs will increase CSP’s competitiveness compared to other renewable energy and the electricity market in general, as well as its acceptance within local communities, achieving a big step forward in the SET plan goals for CSP technology by 2020. The conso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Enable Ancillary Services bY Renewable Energy Sources'.

assistant: **Concept**

The stability and security of the traditional electrical power systems is largely based on the inherent properties of synchronous generators (SGs). Such properties are: the grid-forming capability, the inertia, the damping of transients, and the provision of large currents during faults. The growing penetration of converter-interfaced (thus inertia-less) Distributed Renewable Energy Sources (DRES) will eventually replace dispatchable SGs and increase power volatility, causing large frequency deviations and voltage regulation problems. The increase of SG spinning reserves, the grid reinforcement and the use of central electric energy storage systems are some solutions proposed to tackle this problem. However, due to their centralized approach and high cost, these actions can be undertaken only centrally by TSOs and DSOs. By adopting a unified bottom-up approach, EASY-RES will develop novel control algorithms for all converter-interfaced DRES, to enable them to operate similarly to conventional SGs, providing to the grid inertia, damping of transients, reactive power, fault ride through and fault-clearing capabilities, and adaptable response to primary and secondary frequency control. These new functionalities will be transparent to all grid voltage levels.The EASY-RES approach is based on the distribution network segmentation into small Individual Control Areas, where the DRES and properly sized storage systems will be optimally coordinated via suitably designed ICT infrastructure to provide Ancillary Services (AS) such as inertial response, reactive power support, power smoothing, and contribution to fault-clearing in a bottom-up approach: prosumers and independent RES producers to DSOs, and DSOs to TSOs.  By evaluating the costs and benefits of the developed functional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modelling the therapeutic potential of NUAK1 suppression in colorectal cancer' (NuSiCC).

assistant: **Concept**

Colorectal cancer (CRC) kills up to 170,000 Europeans annually. Although survival rates have improved gradually, new treatment strategies are certainly needed. Hyper-activation of WNT/Beta-catenin signalling occurs in up 93% of CRC cases and MYC appears to be an obligate effector of Beta-Catenin in the gut, making MYC an attractive target for therapeutic intervention. MYC, however, is difficult to target directly, owing to its lack of enzymatic activity or obviously druggable structural features. An alternative strategy is to target the biological consequences of MYC deregulation. The Murphy lab recently showed that MYC overexpressing tumour cells in culture exhibit an ectopic dependency on a little-known kinase called ARK5/NUAK1: whereas cells lacking MYC overexpression are able to withstand NUAK1 depletion or inhibition, cells with overexpressed MYC are unable to maintain energetic homeostasis in the absence of NUAK1, deplete their ATP levels, and consequently lose viability. We have therefor taken a genetic approach to examine the requirement for NUAK1 during tumour development in a genetically engineered mouse model of sporadic Beta-Catenin-driven CRC. Our preliminary results show that NUAK1 is required for CR tumour initiation and, more importantly, that NUAK1 depletion shrinks pre-existing tumours, suggesting that NUAK1 is an excellent candidate target for treatment of CRC.Based on these exciting preliminary data, I now propose to thoroughly evaluate NUAK1 as a target for therapy in CRC and to use a combination of proteomic, phosphor-proteomic and metabolomics analysis to determine the mechanism by which NUAK1 suppression erodes tumour cell viability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Universal, mobile-centric and opportunistic communications architecture' (UMOBILE).

assistant: **Innovation**

Cars, sensors, home appliances, every device in the daily life of citizens is becoming a constituent in Future Internet, adding to the need to reconsider requirements and assumptions in terms of network availability and affordability to support the ever increasing traffic demand. Still, the current Internet can only evolve adequately, if its infrastructure can be devised to accommodate the emerging services. The increased cost of adding new infrastructure and capacity has a drastic effect on rural and remote communities as well as nomadic users as they become marginalized by not gaining access to crucial Internet services. Our goal is to make the Future Internet universally pervasive supporting a diverse set of services. To achieve this, we develop a universal mobile-centric and opportunistic communications architecture, which integrates the principles of Delay Tolerant Networking (DTN) and Information Centric Networking (ICN) in a common framework. We utilize the benefits of both ICN and DTN to enable resource exploitation at minimal bandwidth, opportunistic access to information and more localized access to information through novel caching strategies. UMOBILE focuses on assisting users in getting access to the content they want or content that may be of shared interest to their trust circles. By relying on an instance of the UMOBILE architecture, users are able to share information directly with other peers without relying on infrastructure or expensive connectivity services. The proposed architecture targets the mobile part of the networks, extends Internet connectivity to regions that are not typically covered enhancing network resilience and is fully backward compatible with the current Internet architecture. We will validate our architecture in a real world trial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of assays for the detection and prediction of co- and anti-mutagenic constituents in food with cells of human origin' (HEPADNA), addressing dissemination and exploitation.

assistant: **Impact**

It is well documented that diet and the existing food containments play a crucial role in the aetiology of cancer in humans. In order to perform a reliable risk assessment for human in the present project we plan to develop and validate new assays using human hepatoma and hepatocyte cells systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Challenging the limits of mechanical quantum metrology'.

assistant: **Concept**

Nano- and micromechanical resonators, with their high coherence and low mass, serve as extremely good sensors of small forces and particles. They are especially powerful in combination with optical laser fields, which can measure mechanical motion down to the level where quantum mechanics is needed to describe it. The performance of mechanical quantum sensors, and in fact our ability to measure their displacement, is however limited by fundamental concepts: Heisenbergs uncertainty principle dictates the smallest vibration that can be resolved. And time-reversal symmetry bounds the measurement rate of a sensor. In this project, I challenge both limits  evading them by making nanomechanical resonators interact strongly with temporally controlled and nano-confined light fields. The experiments I propose will project a macroscopic mechanical object in a pure quantum state, through the mere act of performing a strong measurement. I aim to show that such measurements can entangle the objects internal degrees of freedom, and can be used to boost metrology performance. By breaking time-reversal symmetry through optical control, I seek to enhance the sensitivity of mechanical force sensors. I will investigate whether the measurement interaction can be employed to coherently convert optical to mechanical states, and to manipulate optical signals down to the single-photon level.The realization of these goals will radically advance mechanical quantum sensing, create coherent interfaces for quantum communication, and establish novel ways to control light and motion at the quantum level. Moreover, we will gain a new fundamental understanding of metrology and sensing performance in basic systems that transcend the mechanical domain. Finally, these foundational experiments will bring i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multisensory signal processing: From brain-wide neuronal circuits to behavior' (MultiSense) targeting Horizon 2020.

assistant: **Abstract**

Our brain needs to constantly fuse sensory information detected by our multiple senses in order to produce a seamless coherent representation of the world.  Rather than being the exception, this binding process is ubiquitous to sensory-motor integration and is implicated in most cognitive functions. Its impairment is a cause of various pathologies, such as schizophrenia or autism. Multisensory processing operates on all brain levels from primary cortices over subcortical structures up to higher associative centers, while the smallest operational units are single multisensory neurons. In an interdisciplinary effort, we combine optical developments, genetics and neuro-computation to obtain new insights into the activity of brain-wide neural circuits that process multisensory information. To reduce the complexity, we study the small transparent brain of zebrafish larvae as a model system. We focus on gaze stabilization as an inherently multisensory model task that is conserved among all vertebrates. This reflex uses both vestibular and visual information to drive eye movements in order to compensate for self-motion and maintain clear vision. We will build a novel experimental platform in which a restrained larva will be submitted to vestibular and visual stimuli, as a pilot in a flight simulator. We will optically record the activity of all 100,000 neurons of the animal brain as it performs multisensory integration tasks.  To extract basic principles of how behavior is coded in multisensory neuronal circuits we will interpret the brain-wide activity and the observed behavior with methods from statistical physics. No other system can today provide a similar brain-scale, yet cell-resolved view on the neuronal network dynamics subserving such a complex integration process. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Atrial Fibrillation, Fibrosis and Rotors: New Insights from Imaging and Computational Modeling' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Atrial fibrillation (AF) is the most common type of arrhythmia and causes substantial morbidity and mortality. AF is principally treated with catheter ablation. Unfortunately, the mechanisms that initiate and sustain the arrhythmia are still incompletely understood and, as such, ablation remains a highly operator-dependent procedure with low success rates. Two recent studies promise to lead to better ablation outcomes, showing that a) the amount of atrial fibrosis directly correlates with the non-responsiveness to ablation and that b) AF is maintained by electrical rotors and targeting their suppression improves the success rates. Nonetheless, the lack of a rigorous mechanistic framework of AF pathophysiology deprives those studies of solid fundaments so that their effective value is still debated.This project aims therefore to provide such a framework by exploiting advanced biomedical engineering concepts. The focus will be on explaining and connecting recent experimental findings about fibrosis and rotors. The relationship will be first analyzed in vivo from AF patient data acquired with state-of-the-art instrumentation in the field of interventional electrophysiology. Measured data will be then integrated within a multi-scale personalized computational model of the fibrillating atrium that will determine, on a patient-specific basis, the mechanistic connection between fibrosis and reentries. Furthermore, the tool will provide an in silico environment for personalized ablation planning. Key in the project will be the synergy between complementary state-of-the-art expertise in the fields of medical imaging and computational modeling provided by applicant and host institutions. All partners will strongly benefit from the implied two way knowledge transfer, in terms of c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Narrating Futures'.

assistant: **Objectives**

This project is unique as it identifies a totally new field within Narratology: multiple future narratives. Narratives are traditionally concerned with past events. Even if they claim to be about the future (e.g., utopian tales), narratives treat these events as if they had already happened. In contrast, future narratives in our sense are narratives that preserve the characteristic feature of future time, viz. that it is open, multiple, not yet crystallized into actuality. We do not yet have a grammar, a logic, or a poetics of future(s) narratives. This project promises to offer these. Firmly rooted in Narratology, the project has interesting interfaces with Philosophy, Linguistics, the theory of History, Game Theory, Decision Theory, and Futurology. It will analyze a corpus of future-related 'texts' and conceptualize them so that the narrative mediation of complex multiple futures' scenarios becomes feasible. The impact of the findings of this trailblazing Humanities project will be across the board   not only for the Humanities and Social Sciences, but also for Political, Environmental, and Business decision making, since future scenarios that retain the openness of forked-path or feedback or cross-impact models can only be communicated if they rely on multiple-narrative techniques and devices. 'Narrative' here refers not only to fictional, but also to non-fictional narratives; likewise, the narratives in question are by no means restricted to any one medium, such as language, or print. Movies, computer games etc. are equally in the focus of our research. Necessarily interdisciplinary, it is, however, an incontestably narratological project, because Narratology provides the central paradigm for this new field of enquiry, 'narrative'. To sum up: There is of now no divi