RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SKY WATCH: Introducing European Youth in the World of Scientific Research through Interactive Utilisation of a Global Network of Robotic Telescopes' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The SKY WATCH project aims to introduce the European youth in the truly wondrous world of science and technology by engaging school and university students and young science amateurs in escalating, challenging and innovative multidisciplinary Science Games combining creativity, intelligence and scientific quest. SKYWATCH introduces a pan-European Science Communication and Celebration Initiative, which will reach its peak during the European Science Week 2005, comprising of two main interrelated events:(1) A two-phase European Science Contest (concluding to a central European Exhibition and a Best Projects Award Ceremony) and(2) series of popular science distance learning courses (16 Science Days overall).To perform project activities young people will be given access to an existing global network of 5 remotely control robotic telescopes though the innovative web-based platform, Eudoxos that is currently in use across Europe. The young participants will organize teams (school classes, groups of students, etc.) and design, develop and implement their science projects, comprising astronomical observations with the use of the telescopes and under the guidance and the continuous support of experts. The SKYWATCH web-portal will be launched for this scope providing access to Eudoxos Platform, to advanced collaboration and communication tools and to educational material of high added value, acting as on-line campus for scientific quests. An Integrated Publicity Campaign covering 28 European and other Countries will be implemented. At least 10,000 secondary school students of 28 European Countries, 1,000 university students, 50,000 visitors of science centres, parks and museums and 5.000 visitors (mainly school students) of the central exhibition will participate in projects act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DNA replication during cell differentiation: signaling path and targets modulation' (CORD).

assistant: **Innovation**

Genome duplication is central to cell division. Conversely, terminal differentiation of mammalian cells is normally associated to non-proliferation and DMA replication quiescence. Although both DNA replication and cell differentiation have been widely in vestigated, still poorly understood are the signal mechanisms and regulatory targets that couple and mutually regulate the two processes. The aim of my project is to characterize the features that lead to replication blockage in cells induced to termina l differentiation. The experiments will be carried out in a model of neuroblastoma cells engineered to express the estrogen receptor (ERa). Previous studies have demonstrated that upon addition of 17p-estradiol (E2), these cells undergo growth arrest and differentiation. The timing and the number of cell cycles necessary to convert the neuroblastoma from proliferation to differentiation have been well described as well as several effects underlying the hormonal effects. Thus the model provides a unique opportunity to pursue the research interest above presented. My work will be organized as follows: 1.Analysis of the elements and the mechanisms leading to replicative quiescence in differentiated cells. This line will concern the regulatory path to d ifferentiation, focusing on specific transcription and replication factors. 2.Analysis of replication dynamics in differentiating cells. DNA replication seems to be developmental^ regulated. Shift from proliferation to terminal differentiatio n requires few rounds of DNA replication. This research line will shed light on dynamics of origin usage and replication fork progression during this process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A tool for monitoring and forecasting Available WAter REsource in mountain environment', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The aim of the AWARE project is to provide innovative tools for monitoring and predicting of water availability and distribution in those drainage basins where snowmelt is a major component of the annual water balance, a common condition in Alpine catchm ents. Recent droughts observed in these basins call for the need of an efficient technology to predict medium and long-term flows for sustainable water resources management. The project will develop appropriate mathematical models to represent snow-pack dynamics and snowmelt runoff. These models will be expressly designed to integrate Earth Observation data and in-situ hydrological and meteorological measurements, introducing therefore a novel approach to the representation of the involved physical pro cesses in time and space. Model innovation stems with the enhanced capability of Earth Observation data to provide continuous information on state variables, that can be poorly accounted for using the traditional approach based on input-output control. Model calibration, validation and demonstration will be performed for representative catchments of different geographic conditions (climate, geology, geomorphology, hydrography) in the European Alps. Models will be implemented in a geo-service for tailor ing data and models to different environments under an integrated, but modulated approach capable of effective addressing the specific problems raising from different stakeholders, these including water policy makers, economic (hydropower companies, irr igation schemes, municipal water supply), and social (regional, basin and municipal authorities, citizens) stakeholders. The geo-service, fully compliant with the architecture of the Inspire initiative, will be capable of coupling global and local data to compute, archive, u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pd - ii - catalyzed addition polymerization of polycyclic olefins with functional groups' to be submitted under Fourth Framework.

assistant: **Abstract**

The incorporation of functional groups in rigid cycloaliphatic polyolefins is envisioned to lead to macromolecular materials with very good mechanical strength and high heat distortion temperatures. In addition, they are expected to provide enhanced intra- and intermolecular interactions which may promote miscibility or compatibility of polymer blends. In the initial stages of the project, novel ionic Pd(ll)-complexes will be designed which will be used as the catalysts for the addition polymerization of strained cyclic olefins with functional groups including carboxylic acid, ester and anhydride substituents The catalysts will be tested in respect of their activity toward monomers with a different substitution pattern including endo- and exo-, and mono- and di-substitution of polycyclic olefins. Copolymerizations with bicyclo(2.2.1)hept-5-ene-2-carboxylic acid and subsequent neutralization with alkaline and alkaline earth metal hydroxides should provide access to rigid ionomers with 0.01 to 0.10 alkali metal carboxylate groups per repeating unit. The ionic aggregates represent electrostatic (reversible) crosslinks between the polymer chains of the matrix phase and thereby lead to good thermomechanical performance. Techniques for structural analysis will include transmission electron microscopy and xray analysis. The mechanical behaviour will be evaluated by tensile and impact testing. The influence of low molecular weight carboxylates as additives for plasticization will be assessed. Ion pair - cross aggregation might promote phase compatibility with an elastomeric ionomer component and could lead to polymer blends with increased toughness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Mechanisms Linking Early-Life Stress and Resilience to Climate Change in Amphibians'.

assistant: **Innovation**

Climate change imposes a myriad of environmental stressors to wildlife that are particularly challenging to early life-stages in animals with complex life histories such as amphibians. Poor developmental conditions have been shown to impact survival later in life. As amphibians are the most threatened vertebrate class, identifying mechanisms that shape their capacity to cope with environmental stress is vital for predicting population responses. In AMPHISTRESS, I aim to investigate how early-life stress can affect resilience to climate change in amphibians by exploring the underlying neuroendocrine and physiological mechanisms mediating the interplay between environmental change, behaviour, and stress physiology. Hereto, I will employ an interdisciplinary approach exposing amphibian larvae to sub-optimal developmental conditions (elevated temperature, pond drying, hypoxia) and first assess the resulting impact on glucocorticoid “stress” hormone levels, oxidative stress, animal personality/coping style, growth, and short-term stress responsiveness before and after metamorphosis. Then, I will assess the movement behaviour of juveniles toads under semi-natural conditions to understand if early-life stress-induced altered growth trajectories interact with dispersal capacity. Lastly, I will build heuristic models to identify how individual stress-responses to climate change can scale up to affect population dynamics. AMPHISTRESS will provide novel information on the effects of climate change-induced habitat alterations on amphibians, and the importance of habitat connectivity for amphibian dispersal, survival, and population persistence thereby generating knowledge with direct conservation value. Finally, this project will be the cornerstone of my long-term research goals to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Identification of new antigenic peptides on human tumor cells that are recognised by cytotoxic or helper t lymphocytes' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content A number of antigens have been identified on human tumors that are recognised by autologous cytotoxic T lymphocytes (CTL). Some of these antigens are encoded by MAGE genes, that are specifically expressed in a wide range of tumors. MAGE-encoded peptides are currently used for immunisation protocols of melanoma patients to induce specific anti-tumor immunity and subsequent tumor rejection. However, only patients that express the MAGE gene in combination with the relevant HLA type are eligible for the immunisation with the currently known peptides. Identification of new peptides that bind other HLA types will therefore allow more patients to benefit from immunisation with specific peptides. In addition, immunisation can be performed with multiple peptides, which may improve the immunisation efficacy. Specific helper T lymphocytes are important for the induction and maintenance of a cytotoxic T lymphocyte response in vivo. Immunisation with a combination of HLA class I and class II-restricted peptides may activate both CTL and helper T lymphocytes and, therefore, enhance the efficacy of an anti-tumor response. We intend to identify new antigenic peptides encoded by MAGE genes, that are recognised by cytotoxic T lymphocytes or by helper T lymphocytes. Since MAGE genes encode large proteins, new peptides may be identified in these proteins that bind other HLA class I or class II molecules. For this purpose, dendritic cells will be loaded with the recombinant MAGE protein, or MAGE genes will be expressed in dendritic cells by pox virus-mediated gene transfer. The dendritic cells will be used to prime T lymphocytes, that are subsequently tested for peptide recognition in cytotoxicity assays or cytokine production assays or cytokine production as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Technology Of Protein delivery in Extracellular Vesicle-induced Cardiac Repair' in the context of a Horizon Europe call.

assistant: **Objectives**

More than 3.5 million people are newly diagnosed with heart failure every year in Europe with a long-term prognosis of 50% mortality within 4 years. There is a major need for more innovative, regenerative therapies that have the potential to change the course of disease. In the ERC-Extracellular Vesicle-Inspired CArdiac REpair (EVICARE), I hypothesized that we can recondition heart failure by stimulating cardiac repair with extracellular vesicles that are derived from progenitor cells. From the EVICARE application results, however, we realized that enhancing the therapeutic load of EVs will enhance their functional effect size to treat chronic diseases. In TOP-EVICARE(Technology Of Protein delivery in Extracellular Vesicle-induced Cardiac Repair), I aim to explore active loading and release systems that will allow protein therapeutic loading in extracellular vesicles to stimulate myocardial repair.Within this project, I aim to:I.Validate our innovative EV-loading strategy by assessing biodistribution and functional delivery in vivo, and exploring the potential for upscaling GMP production to meet industry standards and requirements;II.Conduct a comprehensive intellectual property (IP) landscape analysis to establish freedom-to-operate (FTO) and ensure that our technology can be commercialized without infringing on existing patents;III.Execute an in-depth market, competitor, and stakeholder analysis to identify strategic opportunities and potential challenges in the EV-based therapeutic landscape; andIV.Develop a robust and detailed business plan to effectively guide the commercialization of our loading technology, thus bringing a transformative solution to the treatment of various diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dust in the wind — a new paradigm for inflow and outflow structures around supermassive black holes' to be submitted under Horizon 2020.

assistant: **Abstract**

Active galactic nuclei (AGN) represent the active growing phases of supermassive black holes. For the first time, we are able to resolve the dusty gas on parsec scales and directly test our standard picture of these objects. While this “unification scheme” relates the parsec-scale IR emission with a geometrically-thick disk, I have recently found that the bulk of the dust emission comes from the polar region of the alleged disk where gas is blown out from the vicinity of the black hole. Along with these polar features, the compactness of the dust distribution seems to depend on the accretion state of the black hole. Neither of these findings have been predicted by current models and lack a physical explanation. To explain the new observations, I proposed a revision to the AGN unification scheme that involves a dusty wind driven by radiation pressure. Depending on their masses, velocities, and frequency, such dusty winds might play a major role in self regulating AGN activity and, thus, impact the interplay between host and black hole evolution. However, as of now we do not know if these winds are ubiquitous in AGN and how they would work physically. Upon completion of the research program, I want to• characterise the pc-scale mass distribution, its kinematics, and the connection to the accretion state of the AGN,• have a physical explanation of the dusty wind features and constrain its impacts on the AGN environment, and• have established dust parallax distances to several nearby AGN, as a multi-disciplinary application of the constraints on the dust distribution.For that, I will combine the highest angular resolution observations in the IR and sub-mm to create the first pc-scale intensity, velocity, and density maps of a sample of 11 AGN. I will develop a new model tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Artificial intelligence-based Parkinson’s disease risk assessment and prognosis' (AI-PROGNOSIS) under Horizon Europe.

assistant: **Objectives**

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, with a multifactorial aetiology, heterogeneous manifestation of motor and non-motor symptoms, and no cure. PD is often missed or misdiagnosed, as early symptoms are subtle and common with other diseases, allowing for considerable damage to occur before treatment. Moreover, selecting the optimal medication regimen is usually a lengthy, “trial and error” process, leading to critical, costly non-adherence. Following a trustworthy and inclusive approach to AI development and based on multidisciplinary expertise and broad stakeholder engagement, AI-PROGNOSIS aims to advance PD diagnosis and care by: 1) developing novel, predictive AI models for personalised PD risk assessment and prognosis (in terms of time to higher disability transition and response to medication) based on multi-source patient records and databases, including in-depth health, phenotypic and genetic data, 2) implementing a system of biomarkers informing the AI models by tracking key risk/progression markers in daily living, and ultimately 3) translating the models and digital biomarkers into a validated, privacy-aware AI-driven toolkit, supporting healthcare professionals (HCPs) in disease screening, monitoring and treatment optimization via quantitative, explainable evidence, and empowering individuals with/without PD with tailored insights for informed health management.


**Keywords:** Parkinson's disease, Risk, Progression, Medication response, Trustworthy AI, Predictive models, Digital biomarkers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting RAS oncogene addiction' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Lung cancer is the most common type of malignant tumour worldwide and the leading cause of cancer-related death (335,000 deaths per year in Europe). The KRAS oncogene is frequently activated by point mutation in human lung cancer and mutations in the RAS family oncogenes are responsible for driving some 20% of all human malignancies. Most cell lines from RAS mutant tumours remain “oncogene addicted” to continued RAS function. There is therefore a pressing need to develop cancer therapies that target RAS.To date it has proven impossible to target the RAS proteins directly and it is unclear whether combined targeting of downstream pathways that RAS controls will prove effective. We have previously probed the unique vulnerabilities of RAS mutant cancer cells using synthetic lethal genome-wide screening approaches. This has led to the identification of a transcriptional programme controlled by GATA2 that is selectively essential for RAS mutant lung cancer cell survival. Deletion of GATA2 leads to dramatic regression of RAS induced in lung cancer in mouse models. Although GATA2 itself is likely to be undruggable, combined suppression of two GATA2 regulated pathways, ROCK and the proteasome, with clinically approved inhibitors causes marked tumour clearance.We propose to investigate the ability of these promising targeting strategies to impact on various RAS induced cancers and also to investigate mechanistic aspects of this dependency on GATA2 function. We will test the effect of GATA2 deletion or ROCK/proteasome combination therapy on RAS mutant tumour maintenance in the setting of p53 loss, both in lung and pancreatic cancer. In addition, we will determine the mechanisms involved in the dependency of RAS mutant cancers on these pathways in vivo, including investigating eff