RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Trondheim Marine Systems', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Principal characteristics of the facility and of the support offered to users: The LARGE SCALE FACILITY for Measuring, Monitoring and Modelling of Marine Systems (FourMS) offers a range of outstanding facilities for integrated research involving marine technology and marine sciences, focusing on improvement and utilizing the advanced tools needed in monitoring of the marine environment, its resources and their sustainable use, i.e. European Commission priority topics in MAST, Environment and FAIR programmes and the themes 'Unlocking the resources of the living world and the ecosystem' and 'Marine technologies' in the 5th framework programme. The LSF provides access to, experimental tanks: indoor ocean basin, large towing tanks, cavitation laboratory, wave mechanics tank, Coriolis tank and wave-generator tanks; some 65 biological tanks/basins; rooms for cultivation of marine organisms, supercomputing facilities, 'state of the art' telemetering buoys, special instruments and sampling gear. The LSF offers access to 3 unique natural environments (a natural mesocosm, the well-studied Trondheimsfjord and Haltenbanken), all characterized by clean coastal waters. The mesocosm and the fjord are easily accessible from seaside research/field stations and 2 research vessels. Research visitors to the LSF will be able to carry out research related to sensor platform development and testing, deployment, operation of platforms, data transfer systems platform-land, calibration and testing of physical, chemical and biological sensors, processing and treatment of data, experiments to determine model parameters and define boundary conditions, modelling of hydrodynamics, ecology and single processes; and validation, synthesis, interpretation, quality control and dissemination of data. Quant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SENSOrimotor structuring of perception and action for emerging cognition' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The SENSOPAC project will combine machine learning techniques and modeling of biological systems to develop a machine capable of abstracting cognitive notions from sensorimotor relationships during interactions with its environment, and of generalising this knowledge to novel situations. The machine through active sensing and exploratory actions will discover the sensorimotor relationships and consequently learn the intrinsic structure of its interactions with the world and unravel predictive and causal relationships.Together with action policy formulation and decision making, this will underlie the machine's abilities to create abstractions, to suggest and test hypotheses, and develop self-awareness. Detailed neural models of key brain areas will be embedded into functional models of perception, motivation, decision making, planning and control, effectively bridging and contributing to Neuroscience and Engineering. The project will demonstrate how a naive system can bootstrap its cognitive development by constructing generalization and discovering abstractions with which it can conceptualize its environment and its ownself.The continuous developmental approach will combine self-supervised and reinforcement learning with motivational drives to form a truly autonomous artificial system. A systematic and integrated approach to studying active sensing and motor control in animals in a hierarchy of defined tasks will offer insights into skilled behaviour that will lead to fruitful applications of bio-inspired mechanisms for perception, cognition and intelligent control. The project relies on the synergy between multiple scientific institutions including a SME, an industrial and RTD partners who are leaders in their fields. Throughout the project, continuous interactions bet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Helico-Selective Membrane Transport' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Membrane transport regulation is a sophisticated process only achieved by complex pore-forming membrane proteins. Controlling the transportation of bioactive molecules with high selectivity can pioneer a paradigm shift in the precision of membrane-related applications (e.g., drug and gene delivery, biosensing, signaling, metabolic activity manipulation, etc.).Despite the research effort in membrane transport and significant advances in membrane pore engineering, a critical knowledge gap still hinders the development of pore technologies for high-selective membrane translocation processes. Inspired by the recognition mechanisms of transport-specialized membrane proteins, ChiroPore aims to fill this gap by using helical topologies as recognition patterns in nanopore-mediated membrane translocation for the first time.Inspired by natural tagging recognition systems like nuclear nanopores, ChiroPore’s strategy consists of a two-component system in which matching helical topologies are used as recognition motifs, akin to bolt and nut complementarity. A variety of nuts (transmembrane peptide barrels) and bolts (helical peptides) designed with helical complementarities form the basis of a versatile multivalent key-lock system for tag-selective membrane trespassing of bioactive cargo.I will synergistically combine the advantages of existing membrane nanopore engineering strategies into a novel peptide assembly technology to construct membrane pores with precise internal topology. I propose introducing a helical peptide nucleic acid (α-PNA) origami to synthesize membrane-spanning barrels capable of displaying an array of helical topologies.Overall, ChiroPore technology proposes a tag-selective supramolecular membrane transport system that utilizes macromolecular chirality as a re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'LET´S CARE: BUILDING SAFE AND CARING SCHOOLS TO FOSTER EDUCATIONAL INCLUSION AND SCHOOL ACHIEVEMENT' (2021-2027).

assistant: **Innovation**

Secure attachment relationships play an important protective role against the intergenerational transmission of social exclusion, not only at early stages, but at all school levels. LET´S CARE aims to comprehensively understand and improve the caring dimension of educational inclusion and school success. The project main objective is to identify determinants affecting student security as a root cause of underachievement, disengagement and school dropout, at 4 different ecological levels: individual, relational, community and political. LET´S CARE will create a theoretical and practical framework to foster Safe Learning, Safe Teaching, Safe Schools and Safe Education in each level as an approach to break the chain of transgenerational transmission of educational and social exclusion. This approach will generate lower rates of school failure, poor learning outcomes and early school leaving. The main proposal breakthrough is based on considering a relational response to educational exclusion and inequality, resulting in a model for understanding the importance of security to address underachievement and early drop out, and a relational approach to inclusive practices at school that will be translated into tools, recommendations and guidelines for action, from ECEC to secondary and Second Chance schools. A multilevel, multistage and intersectional research, exploring different European educational contexts, will be implemented, including120 schools, 18,000 students, and 2,400 teachers from 6 European countries in 4 schools stages, with special attention to multi-disadvantaged learners. LET´S CARE, supported by a expert consortium, will implement a holistic methodological approach, including cocreation mechanisms, and will translate research findings into political approach,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular basis of the outer membrane permeability' in the context of a Seventh Framework call.

assistant: **Objectives**

Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallization of molecular resistance components and all-atom modeling to determine the kinetics of permeation. Our particular strength lies in the identification and quantification of transport proteins involved in membrane permeation at the cellular level combined with our expertise in quantifying the rate limiting steps of translocation at atomic level. Based on our experience we intend to:1.develop multiple assays to determine intracellular concentrations of small molecules2.increase the overall structural knowledge of outer membrane proteins3.extend knowledge on active-uptake transport systems, such as iron transport4.identify novel targets whose modulation can alter the penetration of other small molecules5.obtain as complete a picture as possible of small molecule penetration into and efflux out of bacterial cellsCombining the research question at different levels we expect to understand the complexity of membrane permeability. In particular, we are convinced that our molecular approach is able to provide a general template for a guided design of antibiotics to achieve high permeability. In addition, we will create a data base to allow the sharing of antibacterial R&D information on an unprecedented level.  Also, via careful analysis of this information we intend to provide learnings as best practices that will lead to an increase in the overall efficiency of antibacterial R&D.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Clonal analysis of the progenitors for the mouse anteroposterior axis and adult muscle' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Embryonic development occurs via successive lineage segregations leading to the progressive compartmentalisation of a pluripotent embryonic primordium into broad cellular domains and eventually into specific tissue types. Over the last decades, an abundance of information has been gained into the genetic and molecular regulation of theses processes, while little is still known concerning the cellular aspects of development. The purpose of the proposed work is to provide a better insight into cellular behaviour responsible for tissue diversification and patterning along the anteroposterior axis by addressing previously unresolved questions relating to the genealogical relationships of distinct cell populations, the unipotent or multi-potent nature of their pro genitors and the existence of clonal continuity between different axial domains.It also aims to examine the relationship between these early patterning events and the development of adult muscle during secondary myogenesis. Information derived on these is sues will have significant implications for future healthcare strategies and the development of cell therapies in particular for muscle degenerative diseases. The project will take advantage of a recently developed approach for retrospective lineage analysis which is clonal, non-invasive, non-biased in respect to the cell initially labelled, and allows visualisation of a clone at any time after its initiation. Thus, this approach is the only suitable for providing a definitive answer to the genealogical relationships of cells and for describing cellular behaviour throughout development. Implementation of the project will complement the researcher's previous experience and thus contribute to her training towards professional independence. The mobility will be benef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'AMOLF integrated training in nanophotonics, femtophysics and mesoscopic biophysics' (AMOCROSS).

assistant: **Innovation**

The aim of the AMOCROSS project is to provide high-level interdisciplinary training to early-stage researchers at the interface of three emerging fields: nanophotonics, femtophysics and mesoscopic biophysics. Europe has a strong, often leading, position in these strategic fields of science. Purely mono-disciplinary training will not provide the best preparation for young scientists who will form the core of the future knowledge-based economy. For this reason, an early-stage training program is offered that is, from the start, interdisciplinary. In practice, this means that the trainees will work on a research project that bridges at least two of the three topics listed above.The FOM Institute AMOLF in Amsterdam has structured its research in large research units. Individually, each unit aims to be at the forefront of its own core field yet the day-to-day research is strongly linked to that of the other units. AMOLF has an active interaction with industry; one AMOLF group is even located at Philips Research and AMOLF aims to extend industrial collaborations of this kind. The aim is to offer young scientists the experience of working in such a dynamic, competitive interdisciplinary environment. The three fields mentioned above are related by the techniques and methods employed.The research in the fields covered by the program offers exciting scientific challenges with clear technological implications. Comprehensive research lines are offered on three topics, each of which contains two projects that link two o f the three research fields. One aim of the cross-training experience at AMOLF is to show prospective students that these research fields and their future applications should never be seen in isolation. To emphasize the importance of consolidating" experimental obser
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'THE ORIGIN AND IMPACT OF COLOUR CATEGORIES IN THOUGHT AND LANGUAGE'.

assistant: **Innovation**

This proposal outlines a cutting-edge five year project which will push the frontiers of colour category research, and will resonate throughout the cognitive and social sciences.  Humans can discriminate millions of colours (Zeki, 1993), yet language refers to colour using a number of discrete categories (e.g., red, green, blue).  These colour categories are also present in ‘thought’ (e.g., in colour judgements / memory).  There has been considerable multidisciplinary research into the origin of colour categories and how colour categories in thought and language relate.  However, major theoretical challenges remain.  The ‘CATEGORIES’ project, led by Franklin, will tackle these crucial challenges with the aim of establishing a new theoretical framework for the field.  So far, Franklin has made a major contribution to the field by providing converging evidence that infants categorise colour.  The ‘CATEGORIES’ project will investigate new ground-breaking questions on the relationship of these ‘pre-linguistic’ colour categories to the world’s colour lexicons, using a diverse range of methods (e.g., infant testing, computational simulations, psychophysics). The project also aims to resolve the long standing debate about the impact of colour terms on perception (e.g., Whorf, 1956), pioneering a ‘Neuro-Whorfian’ approach to the debate.  This approach will use neuro-physiological methods to firmly establish the extent to which speakers of different languages ‘see’ colour differently.  The new questions, approaches, data and theory provided by the ‘CATEGORIES’ project, will lead to major advances in colour category research.  The project will also lead to major advances on issues that are fundamental to understanding the complexity of the human mind (e.g., the interaction of lan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Inorganic Polyphosphate: Synthesis and Functions, relationship with Inositol Polyphosphates' (POLYPHOSPHATE).

assistant: **Concept**

Cellular regulation by soluble inositol phosphate messengers has yielded surprising knowledge that reaches well beyond the rigorously characterized regulation of Ca2+ release by inositol 1,4,5-trisphosphate (IP3), the best-known inositol phosphate. Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that have a range of signaling functions. The best-characterized inositol pyrophosphates are diphosphoinositol pentakisphosphate (IP7) and the bis-diphosphoinositol tetrakisphosphate (IP8).  The activity of inositol pyrophosphates appears to be related to their rapid turnover in cells and also to their pyrophosphate groups, considered to contain high-energy bonds and unique signaling molecules implicated in regulation of processes, including apoptosis, telomere maintenance or vesicular trafficking. Inositol phosphate signaling molecules can directly mediate protein phosphorylation, a new way in which signals can be transduced in cells.  Another phosphate molecule, inorganic polyphosphate (poly P), found in every living-cell, is a chain of many tens or hundreds of phosphate residues linked by the same phosphoanhydride bonds as in ATP. Poly P likely was a phosphorylating agent and catalyst of peptide bond formation in prebiotic times. It has been shown that poly P is essential in stringent response, survival for bacterial responses to stresses, starvation and pathogenesis.  Yeast mutants, affected in enzymes of the inositol pyrophosphate synthesis have reduced intracellular poly P levels suggesting that inositol pyrophosphates are necessary for poly P synthesis and maintenance. The mechanism by which inositol pyrophosphates are able to transduce the cellular phosphate status into a cascade of signaling events is unknown.  The present proposal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Raman and AFM Integrated Stem Cell Exploration of Differentiation' under Horizon 2020.

assistant: **Concept**

The control of stem cell fate via external stimulation (ES) is a vital contribution to the advancement of tissue engineering (TE) for regenerative medicine (RM).  In this project we propose a highly sensitive real-time characterisation of stem cells during applied ES in order to fully understand and elucidate cellular mechanisms during differentiation. This will be achieved using three major vectors of research; new conductive polymer (CP) materials for the ES of stem cells, Atomic Force Microscopy (AFM), and Raman microspectroscopy (RMS) live cell phenotyping. Real-time characterisation using AFM can directly measure single cell elasticity changes from differentiation mechanics such as reorganisation of the cytoskeleton. RMS of living cells can determine the progression of differentiation through changes in biomolecular composition. The combination of these two techniques will provide significantly improved single stem cell characterisation over current techniques, and is fast, non-invasive, and non-destructive.The differentiation of the stem cells will be driven by external electrical and mechanical stimulation delivered by new CP materials. Control of the ES coupled with the real time characterisation of cells will bring about new understanding of how this ES influences the differentiation of stem cells into the desired phenotype. Improved stem cell differentiation will further refine our knowledge in the TE field, and producing specifically fated cell phenotypes will improve the clinical application of TE for generating new tissues for applications such as cardiac, wound, or bone repair.