RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Dissecting the context-specificity of genetic immune regulation in plasmacytoid dendritic cells'.

assistant: **Innovation**

Antiviral immunity and autoimmune diseases exhibit high interindividual variability. Despite intensive research, the genetic and molecular basis of this variability is incompletely understood. A key player of the immune system is the plasmacytoid dendritic cell(pDC). Recent single-cell work revealed functionally distinct pDC subsets. Considering that pDCs respond to many pathogens, this highlights a previously underappreciated functional diversity of pDCs.I hypothesize that the genetic regulation of pDCs plays a fundamental role in explaining antiviral response and autoimmune variability. Based on my previous work on immune cells, this genetic regulation is expected to be highly context-specific depending on cell type, cell response, ancestry populations and sex among other factors.The overarching goal of this proposal is to elucidate the context-specificity of immune response and its genetic regulation in pDCs to improve our understanding of human antiviral response variation and pinpoint undiscovered disease pathways of autoimmune diseases.To this end, I will generate population-scale, linked scATAC-, sc3’RNA- and scLong-read cDNA-seq data of baseline and TLR7-stimulated pDCs from healthy individuals across three ancestry populations. I will identify novel pDC subtypes and their immune-regulatory circuits by integrated multiome analyses. Molecular quantitative trait loci(QTLs) and their degree of context-specificity will be used to build prediction models of genetically determined immune responsiveness and decode autoimmune disease loci to develop mechanistically anchored interventions for precision medicine.ImmGenDC will gain fundamental insights into the variability of antiviral immune response that will enable the development of new treatments as exemplified by the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European molecular simulations training program' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The EuroSim Early Stage Training program is hosted by five different European partners from Germany, France, the Netherlands, and the United Kingdom. With this program we aim at setting the standard for a European PhD program in Molecular Simulations. The training is based on collaborative research projects in which different types of molecular simulation techniques are used to study an experimental problem in (bio) material science.In addition to the research training, we offer a comprehensive set of courses providing the scientific background of the various simulation methods and advanced tutorials that introduce the researchers to the state of the art in a particular field. During the entire training program special attention is given to those skills that are beyond the need for pure research, but are essential for a successful career in science. The link of the training to CECAM, the European centre for networking activities in this field, gives this program a truly European dimension.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'METAclustered, SME oriented European Open Innovation Test Bed for the BUILDING envelope materials industrial sector using a harmonised and upgraded technical framework and living LABS', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

To reach the COP21 goal of nearly-zero energy, zero emission buildings MBLabs Labs strives to unleash the innovation potential of the SMEs of the Construction sector by lowering the entry barriers to test innovative solutions in a network of testing facilities in RTOs and Living Labs in 13 countries, most EU member states (ES, FR, BE, IT, DE, TR, UK, LU, PL, SE, HU, AT, IE) allowing a direct feedback from the end-users during the final development stages. The MBLabs concept consists of 5 innovation pillars: 1) SME outreach by metaclustering & Open Innovation Digital Platform as cornerstones to engage and support SMEs in innovation and testing based on the networks of MBLabs’ 40 consortium partners, targeting over 180 clusters and building upon the sister H2020 METABUILDING project which reaches out to 9000 SME cluster members. 2) OITB Brokerage Business Model: the SEP will be a light brokerage structure in the form of an association - with the consortium partners as members - that serves as a business provider to entities running testing facilities and/or providing innovation services for building envelopes and finances itself through membership fees, adapted to the size and financial capacities of its members, market place revenues and a commission for the brokerage service. 3) Harmonised testing framework for building products development: consisting of guidelines for the characterization of smart/active systems, a detailed and validated energy model and LCAs to assure the application of EU regulatory practices. 4) O3 Building Envelope Testbench (standardized, replicable, affordable, Digital Twin enabled): first fully replicable, standardised, cost-effective Open Source/Open Data/Open Access Building Envelope Testbed enabling virtual testing and made available (co-fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bridging the Games Research-Practice Gap through Theory Translation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

How can theory inform design practice? This question is among the grand challenges in both Human-Computer Interaction (HCI) and games research. Despite numerous efforts to bridge the research-practice gap, the two poles seem irreconcilable. Instead of a robust and generalizable knowledge base to tackle foundational problems around technology use, cumulative knowledge building is impeded by weak empirical studies and rampant theoretical misconceptions. Instead of providing practitioners with useful theory-based insights, research results often remain too abstract and not sufficiently actionable to be adopted into design practice.THEORYCRAFT tackles this conundrum by means of theory translation, demonstrating how theory needs to be transformed and specified to bridge research and design practice. Building on the PI's excellent track record in theory-building games research, we approach theory translation from four angles: 1) We investigate how game design practitioners make use of theory to identify avenues for productive theory translation. 2) We translate theoretical propositions from psychology to build explanatory theories of ill-understood games phenomena. 3) We develop translational resources that convey theoretical propositions in a manner that is useful and actionable for game design. 4) We evaluate the translated theories in terms of their utility to bridge research and design practice. Individually, each angle will result in important advances in HCI and games research. Collectively, THEORYCRAFT will produce a breakthrough in transparent and systematic theory translation, which will radically transform how knowledge is built, represented and disseminated – steering HCI and games research towards greater scientific integrity, practical relevance, and impact.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A multimodal approach to tendon mechanobiology' in the context of a Horizon 2020 call.

assistant: **Objectives**

Achilles tendon ruptures are common and costly, and more than 50% heal unsuccessfully. Tendons respond to mechanical load over time and loading is fundamental for good mechanical performance. However, the regulatory mechanisms are still largely unknown. The main objective of this proposal is to clarify how intact and ruptured healing Achilles tendons are responding to mechanical load. The hypothesis is that the underlying mechanisms can be elucidated through an advanced multimodal approach that combines novel experimental and numerical models across several length scales to clarify the distinct adaptive response of elastic and viscoelastic mechanical behaviour. The proposal combines well-controlled in vivo animal experiments that are uniquely characterized (in situ) to develop and validate novel adaptive computational (in silico) models that can comprehensively predict the spatial and temporal tissue distributions and biomechanical behavior of healthy intact and ruptured healing tendons. On each length scale, experimental mechanical tests are carried out concurrently with 3D/2D high resolution imaging/scattering (in situ), to clarify how the inhomogeneous meso-, micro- and nanostructures behave under loading, in a setup planned to deliver optimal data for development and validation of computational models. The interdisciplinary project will deliver high-impact science where the multimodal approach on several length scales could establish new paradigms in tendon biomechanics and mechanobiology. Further, it will lift bioengineering to new levels by unravelling the link between load-controlled molecular mechanisms and viscoelastic mechanical response. It will deliver a novel validated computational framework that the research community may use to propose enhanced solutions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Productive Spatial Accelerator Programming'.

assistant: **Concept**

We propose a productive and efficient programming model to overcome the challenges posed by the end of Moores law. Our model bases on a fundamentally new spatial viewpoint that considers the computational structure of applications. The growth of the computing industry as well as the development of society at large has relied for 50 years on an exponential scaling law that is now coming to an end. The combination of multiple specialized components into a fundamentally heterogeneous system is one of the most promising approaches that drives the IT industry. Latest advances in computer architecture and silicon design enable cost-effective specialized accelerators. Those range from single-purpose designs, such as deep neural network chips, to general purpose graphics processing units and are combined into complex systems. However, programming these heterogeneous spatial systems that range from single systems on chip to million-core supercomputers is a fundamental challenge of our time. Prevalent parallel programming abstractions largely ignore the structure of the computation and guide programmers to design threads of execution that are scheduled to the machine. We depart from this temporal model to a spatial formulation where we express programs as parametric graphs that are mapped as first-class objects by a human-guided compilation system. We ensure productivity by designing a Python-based frontend and integrate the system with modern web technology. Our programming, compilation, and tuning system will substantially advance the state of the art in computing by supporting the graphical mapping of program graphs to spatial accelerators. We will demonstrate our methods on three challenging real-world applications in important domains. We strongly believe that, without holis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dynamics and adaptation in human cumulative culture' (CULTAPTATION), addressing dissemination and exploitation.

assistant: **Impact**

Human culture is cumulative, which means that beliefs, art, technology, society etc. are results of many generations of cultural change. In light of biological evolution, the rise of human culture is very rapid and so is the cultural adaptation to new environments. How this happened offers a scientific puzzle. The capacity for cumulative culture gives mankind a unique potential to change and improve life, but culture can also impoverish and even ruin human existence. Thus, understanding the dynamics of culture is of the utmost importance.Unfortunately, cultural research has been hampered by insularity of disciplines and lack of unifying well-defined key concepts and valid mathematical models. This proposal brings together scientists with different backgrounds in a joint research effort to gain scientific understanding of the origin and dynamics of human cumulative culture. Such understanding would allow us to obtain a more integrated view of human history but also to make informed decisions concerning the future. We will take a modern evolutionary approach, combining novel and innovative theoretical and empirical research.We ask a number of specific questions about the origins, dynamics, and outcomes of cumulative culture. Since mathematical theory of cumulative cultural evolution is lacking, we will use state-of-the-art mathematics to develop a series of methods for modeling cumulative cultural evolution. These models will be applied to our questions. Empirical research aims at exploring our questions and test specific theoretical predictions. Such studies include archaeological and historical investigations of the cultural evolution of food habits and the evolution of beliefs, moral codes and laws, as well as studies of animal cultural capacities, and laboratory exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Structure and role of biological communities involved in the transport and transformation of persistent pollutants at the marine air-water interface (AIRWIN)' under Fifth Framework.

assistant: **Concept**

The aim of the project is to investigate the structure of biological communities living and growing in the sea surface microlayer (SML), and their role in the transport and cycling of natural organic matter and xenobiotics. This research proposal will provide original data on the identification of organisms living in the SML. It will provide both scientific and biotechnological communities with a collection of organisms with information on:i) their role in the transformation of specific pollutants and;ii) their capacity to produce molecules such asantioxydants which may be used for pharmaceutical applications. The sensitivity of SML organisms to different categories and concentrations of toxic compounds will be assessed to determine if they are suitable bioindicators of atmospheric pollution.The AIRWIN Project provide significant information on the structure and functioning of the sea surface microlayer (SML) as well as a collection of environmental bacterial strains. The SML occurs at least 30-40% of the time at the open global ocean, but its occurrence can be higher in coastal regions were wind speeds are lower. In the Mediterranean Sea, the SML occurs mainly from late spring to early fall and, therefore, is a compartment to be taken into account from the standpoint of the inhabiting biological communities and their role in the transport and cycling of natural organic matter and xenobiotics. An original and interesting result was the comparison of microbial food webs operating at the surface microlayer with those operating in underlying waters. Recommendations were addressed for optimizing the sampling of the surface microlayer. We showed that both, bacterial and phytoplanktonic cells, accumulate in the surface microlayer by the passive and physical process of flotati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimization and clinical testing of Transcutaneous Implant Evacuation System.' under Horizon 2020.

assistant: **Concept**

Up to 700,000 citizens in Europe have undergone ostomy surgery; up to 60% of individuals with an ostomy will never undergo a reversal operation. Approximately 140,000 new stomas are performed every year in Europe and 120,000 in the USA. Patients with a conventional ileostomy have to continuously wear a stoma bag attached to the abdomen for collection of feces. Despite the availability of a large number of light weight, hygienic and discrete bags, many patients suffer from complications such as skin problems, leakage and odor, and for some the mere change of body image results in social isolation. At times, life for many stoma patients means difficult situations when the stoma controls their lives.The disruptive Transcutaneous Implant Evacuation System (TIES®) is a result of several years of research combined with the latest 3D manufacturing technology. It consists of a small tube made of pure titanium surrounded by a porous structure which allows smooth integration with the body tissues. The implant is built up layer by layer into one solid piece with 3D laser sinthering technology. This produces a unique structure with optimized surfaces and enables the use of a material that is clean and without impurities; together these factors promote reliable tissue ingrowth. A first of its kind, TIES will eliminate seepage, odor, noise, and the need for permanently wearing stoma appliance – offering a great improvement in quality of life in patients with ileostomy. The TIES emptying solution also provides a “non skin touch” way to drain the waste, eliminating the skin problems.


**Keywords:** Ileostomy, ostomy, stoma, novel device for ostomy care, drainage bag, stoma bag, life without stoma bag, overcoming social isolation, Transcutaneous Implant Evacuation System, TIES
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Graphene, MXene and ionic liquid-based sustainable supercapacitor'.

assistant: **Objectives**

A paradigm shift in energy storage technology is needed to support the transition towards the climate-neutrality set by the EU’s international commitments under the Paris Agreement, while ensuring the targets of EU’s Action Plan on Critical Raw Materials (CRMs). In this context, GREENCAP joins a multi-disciplinary consortium with 5 Universities, 1 R&D Institute, 6 companies, located in 7 European countries (including Italy, Germany, France, Ireland, United Kingdom, Estonia, and Netherlands) and 1 non-EU country (Ukraine), to unlock the full potential of supercapacitors (SCs) as electrochemical energy storage systems. We will develop a CRM-free technology exhibiting a battery-like energy density (>20 Wh/kg, >16 Wh/L), together with the distinctive superior power densities and high cycle life of traditional electrochemical double layer capacitors.  GREENCAP will exploit layered 2D materials, including graphene and MXenes as electrode materials, and ionic liquids (ILs) as high-voltage electrolyte. The main objectives of GREENCAP are: i) to syntheses/functionalize graphene and MXenes via facile, scalable and sustainable (CRM-free) methodologies, assuring both high surface area and ion accessibility, introducing Faradaic charge storage mechanisms, and improving their quantum capacitance; ii) to produce novel non-/low-toxic and non-/low-flammable IL-based electrolyte with high conductivities, and a high electrochemical/thermal stability, ensuring SC operation at voltage > 3.5 V within -50°C to +100 °C temperature range, thus eliminating the need for sophisticated cooling systems; iii) to validate the novel SC technology at industrial scale by fabricating cylindrical cells at a TRL 6 while ensuring the creation/existence of the complete value chain from material to cell produc