RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Restoring movement lost to stroke' (ReverseStroke), addressing dissemination and exploitation.

assistant: **Impact**

From violinists to metal welders, finely tuned hand and arm movements are the foundation of craft, while all of us rely on proficient use of hands for the activities of daily life. Yet, more than 25 million people worldwide lost functional movements to subcortical stroke. Subcortical stroke often interrupts the communication between the cortex and the cervical spinal cord circuits, which leads to permanent hand and arm paralysis. The result is a vastly reduced quality of life and enormous socioeconomic burden for the affected, their families, and the society. A treatment that can effectively restore functional movements after subcortical stroke does not yet exist. Still, the motor cortex, which orchestrates movements, and the spinal cord motor circuits that directly control muscles remain largely intact. We aim to reverse the hand and arm paralysis of people with subcortical stroke by developing a digital bridge that reconnects the motor cortex with the cervical spinal motor circuits. This brain-spine interface consists of fully-implantable recording and stimulation systems that link cortical signals to spatiotemporal sequences of epidural electrical stimulation targeting spinal cord regions involved in the production of hand and arm movements. Our preliminary results in people with spinal cord injury strongly indicate that the brain-spine interface can restore natural control of movement and promote neurological recovery. Therefore, we are confident that a cervical brain-spine interface can reverse hand and arm paralysis incurred by stroke and, therefore, become the first viable treatment option for subcortical stroke survivors. Beyond the development and validation of the cervical brain-spine interface for stroke survivors, this project will build the intellectual pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Industry-Academia Partnerships and Pathways on Stratified Combustion for Quiet Low Emissions Aero-Engines' in the context of a Seventh Framework call.

assistant: **Objectives**

The objective of this proposal is to create long-term collaboration between industry and academia within Europe in critical areas of science and technology to develop clean and efficient combustion in aeroengines. Specific goals of the partnership are: • To create a network of highly trained scientists and engineers in a key area of gas turbine combustion research, with both industrial experience and trained in state-of-the-art scientific methods and innovative technologies. • To spark future research initiatives via the interaction of researchers involved in the project with industry as well as other existing networks. • To advance the state of the art in understanding the effects of mixture stratification on emissions and combustion instabilities. The proposal involves two academic (Cambridge University, UK, and Technische Universitaet Darmstadt, Germany) and three industrial partners (Rolls-Royce, UK, Rolls-Royce,Germany, and Camcon, UK). The project will combine the experimental and numerical expertise of all partners to investigate new concepts in turbulent stratified combustion. The results will be immediately used in industry via incorporation into CFD codes and concept development. The project will also significantly benefit Cancom by employing its fast acting valve technology and further developing it for use in a new application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Supramolecules'.

assistant: **Concept**

This Euroconference belongs to the series of the EURESCO conferences on Supramolecular Chemistry. Among the most important topics in supramolecular chemistry: self-recognition and self-assembly, catalysis, and materials, have been already subjects of past conferences. In the continuing evolution of large, nanosized molecules one of the challenging goals is the development of smart" systems with built-in, pre-determined functionalities. In a "bottom-up" approach, such a development can take place through a sequence of steps of increasing complexity:i) Design of molecular building blocks,ii) Supramolecular assembly of molecular components in a specific geometry and energetic sequence. In this regard of particular interest are rod-type systems in which besides a structural built-in-directionality a function of transport (energy, electrons, ions), can be introduced, molecular wires.The possibility to control the properties of the systems and to use this knowledge to construct simple devices such as molecular switches is very appealing. Only with the interaction between synthetic chemists, spectroscopists, electrochemists, material scientists, and industrial researchers this aim will be reached."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Open PLC European research alliance for new generation PLC integrated network' (OPERA) under Sixth Framework.

assistant: **Objectives**

Power Line Communication (PLC) is a broadband telecommunication technology able to use the electricity networks for data transmission purposes, allowing any user connected to the power grid to benefit from a great number of services easily and avoiding expensive and pollutant new wiring. The strategic objective of this proposal is to offer low-cost broadband access service to ALL European citizens using the most ubiquitous infrastructure, Power Lines. Overcoming all barriers that prevent today PLC from being a mass commercial technology that competes effectively with existing technologies through the development of a new PLC generation integrated with existing backbone technologies and EMC full compliant.All efforts will be focused on obtaining: an improved performance in transmission speed, a ready- to-sell and low-cost products, a complete system specification, an unique international regulation, full inter-operability with existing back haul and in-home technologies and a higher market share.OPERA will contribute to develop the European Information Society in concordance with the proposed objectives in the plan eEurope 2005 by:- Increase of competition in access network: PLC networks can be quickly and easily deployed without large investments due to the re-utilisation of electricity networks. PLC is an alternative, competitive, ubiquitous solution for access and in-house distribution that will contribute to have a real alternative last-mile" access network.- Fostering Mass Services availability: PLC features such as transparent integration with different technologies and complete end-user coverage will contribute to the deployment of value-added-services over broadband such as: smart home, video streaming, e-health, telephony, tele-surveillance etc.- European Indust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Develop simple tissue regeneration technologies for the benefits of humanity by leveraging the biomimetic properties and the mechanical advantages of a new silk manufacturing nanotechnology.' (SilkByPass).

assistant: **Innovation**

Silk Biomaterials is a nanotechnology platform company. Its goal is to revolutionize the €85bn global tissue engineering market by leveraging the biomimetic properties and the mechanical advantages of silk. SilkByPass, a device designed for the regeneration of small blood vessels, will be the first product developed by Silk Biomaterials. About 560k/year coronary artery bypass graft surgeries (CABG) are performed in OECD countries. The current golden standard for CABG is autograft (mainly saphenous vein, umbilical vein and mammary artery) and very often more than one graft is required for each procedure. However, autografts are not always available and present several drawbacks: so, there is a global urgent need for man-made grafts. Very few synthetic grafts are on the market and, due to their very poor results, they are used only when autografts previously failed. There is also a need for man-made solutions for peripheral blood vessels, like saphenous veins and carotids. For those vessels there are no autografts available and small calibre synthetic grafts fail in restoring the bloodstream. Our innovative nanotechnology stimulates faster natural human tissue regeneration, with no rejection risks or use of drugs. In addition to that, it is cheaper than other synthetic grafts, allows for easy surgery and doesn’t produce any dangerous degradation product in the patient’s body. Key opinion leaders, clinicians, venture capitalists and medical device companies have already recognized its commercial potential, which is estimated to be around €3.9bn annually in OECD countries. The feasibility assessment to be undertaken in Phase 1 will help Silk Biomaterials further de-risk its technological/commercial viability and plan for a series of activities requiring Phase 2 funding (i.e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Anti-viral innate immunity in cultured aquatic species (AVINSI)' (AVINSI), addressing dissemination and exploitation.

assistant: **Impact**

Despite the impact that viruses have on aquatic organisms, relatively little is known about what farmers can do to prevent and treat viral diseases and how fish and invertebrates fight these infections. Thus, the project aims to characterise anti-viral innate immunity in fish, bivalves and crustaceans in order to provide new approach for the control of viral infections in aquaculture species. Some molecules and genes involved in anti-viral innate inhumanity will be defined and compared in different species. Selected anti-viral effectors will be monitored in vitro and in vivo assays potential anti-viral effects in different cellular and animal models. Furthermore, expression of selected molecules encoding genes will be analysed in healthy and virus-infected individuals. Candidate molecules and genes will be supplied for further exploitation in aquaculture and development of control tools against human and animal viral diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multiwavelength Studies of Galactic Black Holes' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Black holes are some of the most exotic astronomical objects in the universe, and are accordingly the focus of much speculation and study. By definition invisible, they are only detectable when interacting with their environment, either by bending surrounding light or gravitationally capturing enough matter to power other processes whose radiation we can detect.  Depending on the spin of the black hole (BH), its mass-to-energy conversion efficiency can be over 50 times higher than that of nuclear fusion.  The gravitational energy liberated via this accretion process powers many phenomena around BHs and significantly impacts the surrounding regions.  Because many of these phenomena involve complicated geometries, high-energy electromagnetic fields and strong gravity, they are still not well understood.  By observing and modeling the radiation originating from the more extreme regions of BHs and their associated structures in our Galaxy, the planned ITN network intends to reconstruct a more complete picture of the complex physics involved in the accretion process through observations from the radio band to the X-rays and through theoretical work. Training on these subjects will be provided through summer schools on multi-wavelength astronomical techniques and on black hole astrophysics and through dedicated PhD projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cortical circuits of visual perception' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Active perception relies on the concerted activity of populations of neurons in the cerebral cortex. These neuronal populations communicate via dense local and long-range connections, forming complex cortical circuits. While we are beginning to understand the elementary building blocks of such circuits during sensory processing, the circuit-level mechanisms by which top-down signals modulate sensory activity are largely unknown.The core of my proposal is to dissect the cortical circuits underlying top-down guided visual perception during active behaviour. The primary innovation of this proposal is to seek large-scale recordings from single neurons of identified type across all cortical layers in an actively behaving animal performing a well- controlled perceptual task.In Aim 1 we will develop novel paradigms to perform in the mouse visual perception experiments that achieve the ‘gold-standard’ in experimental control set by the behaving monkey. We will train mice in psychophysical tasks that offer exquisite control over the visual stimulus and the behavioural response, yield hundreds of trials per session, can be easily combined with recordings of neuronal activity and allow the manipulation of top-down factors.In Aim 2 we will conduct, for the first time, a detailed, circuit-level analysis of top-down modulations of sensory processing in visual cortex. Specifically, we will identify inhibitory interneurons in the neuronal population with optogenetic techniques and ask how behavioural relevance modulates activity for different cell types.This work will bring us closer to a functional explanation of active perception and will bridge the gap between two hitherto disconnected fields: it will open up questions of Cognitive Neuroscience for the field of Cellular Neuroscience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Ecological Entanglements and Biodiversity in Late Medieval Northern Europe, 1400-1600'.

assistant: **Objectives**

ECOLENT develops a new conceptual-methodological framework to study the impact of ecological entanglements, interconnections between different regions, on biodiversity in a historical context. It will do so by using the late medieval Hanseatic League as a case study. This merchant association bought food products and raw materials in Scandinavia and the Baltic, and exchanged them for manufactured goods in the urbanised Low Countries and England. In this way, they created both economic and ecological connections between different regions of Northern Europe. Humans' modification of ecosystems in one part of the trade network can only be understood by considering it in tandem with interventions in the network's other regions.The project studies the impact of the socio-economic pressures the Hanseatic trade network generated on animal and plant diversity in six regions (Flanders, Guelders, Schleswig, Brunswick-Lüneburg, East Prussia, and Kraków) from 1400 to 1600. It thus draws attention to the history of biodiversity, a subject that has been overlooked in both historical and archaeological studies so far, but whose study has become particularly urgent in the context of current ecological challenges. The methodology developed on the basis of the Hanseatic League's exceptionally rich source material — historical and archaeological — can later be adapted to examine biodiversity in other geographical and chronological contexts. Many scholars have analysed humans' relationship with nature, but none have placed relationships within animal and plant communities at the centre of attention. The main focus has always been on their use as trade commodities. The project proposes a new interpretation of non-human agency that acknowledges both animals' and plants' capacity to respond to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Galileo-assisted robot to tackle the weed Rumex obtusifolius and increase the profitability and sustainability of dairy farming' (GALIRUMI) targeting Horizon 2020.

assistant: **Abstract**

Agriculture provides humans with necessary food and raw materials, but its environmental impact is unacceptably high. Much effort is underway to make agriculture more sustainable, for example through precision agriculture or organic agriculture. In all of agriculture, controlling weeds is a major issue. Weed control with herbicides leads to a large environmental impact. Manual weed control leads to back-breaking labour, high labour costs, and difficulties of finding sufficient labour.The main objective of GALIRUMI is to deliver robot weeding for herbicide-free weed control in dairy farming. Robotic weeding will reduce the environmental impact of dairy farming by eliminating herbicide use and reducing exposure of farm workers to herbicides. It will also remove an important obstacle for dairy farmers to switch to organic production, thereby contributing to an increase in production of organically produced milk and higher incomes for farmers.GALIRUMI will develop and demonstrate a number of innovative technologies in weed detection, weed degradation, autonomous vehicles and robot-as-a-service for precision dairy farming based on precise navigation provided by EGNSS. Several areas of expertise are needed for successful development of practical robotic weeding:•EGNSS•Computer vision for weed detection•Construction of farm machinery•Providing services to farmers•Weed science•Dairy researchThe robotic weeding control system is the end product that GALIRUMI is aiming to put into practice and commercialise, proposed by dock weeding as a service either by:•Laser defoliation system using small robot that requires frequent application in the field. •Medium sized robot system with an electrocution tool that requires single season application in the field. GALIRUMI will significantly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dynamic interplay between phosphorylation and ubiquitination during plant receptor kinase-mediated immunity'.

assistant: **Concept**

The first layer of plant immunity is mediated by the recognition of conserved microbial features known as pathogen-associated molecular patterns (PAMPs) by plasma membrane-localized pattern recognition receptors (PRRs). An immediate downstream substrate of activated PRR complexes is the cytoplasmic kinase BIK1, which is a positive regulator of PAMP-triggered immunity (PTI). The objective of this proposal is to uncover how BIK1 regulates plant immune signalling via the characterization of its substrates in PTI. The host laboratory has recently identified a potential BIK1 phosphorylation motif, which is present in 22 Arabidopsis proteins that are rapidly phosphorylated upon PAMP treatment. Eight of these proteins have been confirmed as true BIK1 phosphorylation substrates and include several proteins involved in protein ubiquitination/deubiquitination, including an E3 ubiquitin ligase and two ubiquitin specific proteases (USPs), which will be the focus of this study. Preliminary data indicate that the E3 ubiquitin ligase is a positive regulator of PTI. Here, I will further characterize the role of this E3 ubiquitin ligase in PTI by characterising the role of its phosphorylation by BIK1, and identifying its substrates and their role in PTI using genetic and biochemical approaches. A similar approach will be used to decipher the role of the two USPs in PTI. The project will directly benefit from my previous experience in working with deubiquitinating enzymes during plant development, which will provide all the necessary technical and theoretical knowledge to ensure the project’s success. This exciting project will allow me resuming my career in science, thus corresponding to the objectives of the People Work Programme. At the end of the project, we will have a better unders