RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'High-Temperature Instruments for supercritical geothermal reservoir characterization and exploitation'.

assistant: **Objectives**

This project aims to provide geophysical and geochemical sensors and methods to evaluate deep geothermal wells up to supercritical conditions (T>380°C). Supercritical geothermal wells are presently non-conventional but may provide a very efficient way t o produce electricity from a clean, renewable source. A deep geothermal well is currently being drilled for this purpose into the Iceland volcanic zone, Iceland as part of the IDDP (Iceland Deep Drilling Project) and with joint funding from Icelandic industry and science. Aimed to explore supercritical wells and to enhance production from them, HITI is to develop, build and test in the field new surface and down-hole tools and approaches for deep high-temperature boreholes.The new set of tools and methods have been chosen to provide a basic set of data needed to describe either the supercritical reservoir structure and dynamics, or the evolution of the casing during production. The set of new instruments should tolerate high temperature & pressure in a highly corrosive environment. Slickline tools up to 500°C and wireline tools up to 300°C will be developed due to the present limitation in wireline cables (320°C).For reservoir characterisation, the measured quantities are temperature and pressure (for fluid characterization, thermodynamic modelling of the reservoir and thermomechanical modelling of borehole integrity), natural gamma radiation and electrical resistivity (for basement porosity and alteration), acoustic signal (with borehole wall images for reservoir fracturing and in-situ crustal stresses), reservoir storativity and equilibrium (from geothermometers and organic tracers) and fluid sampling. For casing and cement integrity, collar location, as well as thickness changes due to corrosion or plugging from miner
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Monsoon Asia as the Nexus for the Transfer of Tantra along the Maritime routes' (MANTRATANTRAM), addressing dissemination and exploitation.

assistant: **Impact**

Tantra dominated the Hindu and Buddhist socio-religious landscape across much of southeastern Asia from ca. the 7th to the 13th century. Once perceived ambivalently by scholars, and often still misrepresented in global pop culture as a form of sexual practice, the study of Tantra has now become a burgeoning academic subfield. However, the impact of Tantra on the religio-cultural history of Asia is still underappreciated, and disciplinary limitations as well as the Area Studies paradigm, fragmenting Asia into discrete areas, hamper our global understanding of this translocal phenomenon. Transcending these boundaries, the project will study Tantra from the perspective of cultural contact between different communities across the geo-environmental region referred to as Monsoon Asia, approaching the phenomenon in a global manner and in terms of connected histories rather than in isolation according to distinct regional contexts. Taking the medieval as its chronological framework, it will investigate textual corpora in Sanskrit, vernacular, and non-Indo-Aryan languages that have seldom been studied in a comparative manner, and complement the textual data with art historical evidence. In so doing, it will frame the emergence, transfer, and transformation of Tantra as a mobile and multi-centric network of people, languages, and objects that circulated across a vast interconnected region sharing common geo-environmental factors (e.g., the periodical monsoon winds). Besides uncovering the interactions between elite and nonelite socio-cultural milieus in the constitution of tantric traditions, it will also transcend the asymmetrical framing of premodern cultural relations between South Asia and the remainder of the wider Indic world, and highlight the shared religious heritage in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Thalamic circuit diversity for active visual processing' (ActiVisTha).

assistant: **Innovation**

Conscious image perception depends on the dorsolateral geniculate nucleus (dLGN) of the thalamus. The dLGN receives signals from the retina and sends its outputs to the primary visual cortex. Already at this first central stage, the brain actively modulates vision by attention and arousal. Yet, the circuit mechanisms for processing and actively modulating visual information in the dLGN are largely not known. Cells and circuits in the dLGN show diverse specializations, which can only partially be explained by known parallel streams of information. I here propose to explore the role of thalamic circuit diversity for visual processing and its active modulation, using cutting-edge technologies at multiple scales, from synapses to long-range connections, that will dissect and interrogate thalamic circuits at unprecedented resolution in the mouse model. I propose novel approaches that will advance beyond the current state of the art.First, we investigate how retinal input diversity functionally transforms into thalamocortical visual feature diversity. Second, we study how diverse modes of inhibition by local interneurons – powerful key players with supposedly multifaceted roles – contribute to the diversity of thalamocortical outputs. Third, we explore how diverse extraretinal inputs influence visual processing and interact during active behavior. Key outcomes will be: (1) the retino-thalamic transformation matrices, (2) a multi-mechanistic model of local inhibition, (3) a spatial map and causality model of different extraretinal inputs. These approaches will provide missing links between input and output diversity that can redefine the role of thalamus. Beyond approaching the question how cognition is implemented, ActiVisTha will have translational and technological impact:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From cells to systems: Pioneering multi-level thrombosis risk prediction models - “ThromboRisk”' (ThromboRisk).

assistant: **Concept**

Thrombosis, an occlusive blood clot, underlies ischemic stroke, myocardial infarction, and venous thrombosis, causing 1 in 4 deaths globally. Its incidence is rising due to an increasingly aging population and increased cardiovascular diseases, along with more cardiovascular implants. Unfortunately, limited understanding of thrombus formation, growth, and rupture hampers patient-specific prognosis. Current treatment strategies include antithrombotic therapy and thrombectomy, but improvements are needed for patient-specific treatments due to common recurrence and unknown impacts on clot fragmentation and thromboembolism.To effectively understand disease mechanisms and accurately predict treatment outcomes, it is crucial to integrate knowledge across multiple scales, harnessing a diverse range of cutting-edge in silico, in vitro, and in vivo technologies. This powerful fusion of emerging technologies holds the potential to revolutionize targeted and personalized medicine. However, there remains a significant shortage of trained professionals capable of co-creating such comprehensive and holistic disease models. ThromboRisk will therefore train 18 exceptional doctoral candidates (DCs) in diverse scientific fields, including mechanobiology, biochemistry, pathophysiology, and modeling. These researchers will collaborate within an international and interdisciplinary consortium to develop a platform advancing our understanding of thrombosis across scales, hereby bridging the gap between micro-level thrombus processes and macro-level impacts on disease prognosis, enabling clinical application. Unlike traditional engineering curricula, which address well-defined problems, ThromboRisk tackles complex, multifactorial ""wicked problems"" in fields of thrombosis by implementing a Ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel bifunctional HAT catalysts for site-divergent C-H functionalizations mediated by photoredox catalysis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The direct catalytic functionalization of C-H bonds, an ubiquitous motif in organic molecules, represents a paradigm shift in the standard logic of organic synthesis. One of the major challenges to render this approach synthetically useful is to control the site-selectivity because most organic molecules exhibit several similar aliphatic C-H bonds.The functionalization of aliphatic C-H bond mediated by photoredox catalysis is a highly active field of research. To date, state-of-the-art site-selective methods in this field rely on substrate control which are inherently restricted to the functionalization of a single C-H bond within the substrate backbone. The innovative aspect of this research program is to target catalyst control to allow the site-selective functionalization of several different C-H bonds of a single substrate. Through this approach, we wish to go beyond the challenging problem of site-selectivity to enable site-divergent functionalizations. Such a breakthrough would provide a new tool for a flexible and streamlined access to molecular complexity from chemical feedstocks.To achieve our objectives, we plan to develop novel bifunctional catalysts incorporating one moiety able to engage into dynamic non-covalent interactions with the substrate and another functional group able to perform Hydrogen Atom Transfer (HAT) processes. These two functional groups are connected by an inert spacer which will position the HAT unit in proximity to a particular C-H bond of the substrate, thus controlling site-selectivity for the C-H activation event. By varying the nature of the spacer, we expect to selectively functionalize several different positions of linear alkyl chains possessing almost undistinguishable methylene C-H bonds.Overall, BICACH aims at using simple bif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Targeting Myc ubiquitination for cancer therapy' under Sixth Framework.

assistant: **Concept**

c-myc is a protooncogene deregulated in a wide range of human cancers. Aberrant Myc expression due to amplifications or translocations is often associated with tumour aggressiveness and poor prognosis.Importantly, even transient inactivation of Myc is suff icient to inhibit growth of certain tumours making Myc a particularly interesting protein for therapeutic targeting. Involvement of the ubiquitin pathway in regulating Myc function provides a valuable opportunity to modulate activity of this protein.We propose to identify novel regulators of Myc stability through genome-wide siRNA library screens using fluorescence-based sorting. Based on previous studies, identified molecules will include enzymes that modify Myc directly, such as kinases or acetylases, and may include components of the degradation pathways, such as deubiquitinating enzymes (DUBs).Many of these enzymes are either known to be suited for pharmacological inhibition (e.g. kinases) or are expected to be so (DUBs are isopeptidases and such enzyme s can be inhibited with small molecules). We expect that this project will define a feasible strategy to target deregulated Myc function in human cancers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'North-south climatic connection and carbon cycle over the last 250 kyr.' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

To analyse the climate signals in Greenland and Antarctic ice cores, and to study North-South climatic connections and their dynamics. The project consists of three parts: Further studies of ice core data, in particular based on the GRIP core,  modelling the isotopic composition of precipitation to help in the interpretation of the ice core signals, and  climate and carbon cycle modelling to analyse the mechanisms of North-South climatic connections.  The ice core analyses will include study of possible chemical transformations altering the isotopic composition  of CO2 in the GRIP core, and further analysis of the isotopic composition, trace gases and dust contents. From  these data the climatic forcings and conditions (temperature changes) will be refined and compared with other  proxy data (in particular the oceanic records). Special attention will be placed on the correlation and phasing  of the signals between North and South, and on abrupt changes, and on estimates of climate sensitivity based  on the simultaneous records of forcing factors and temperature.  A detailed modelling study will be performed to better quantify the ice core palaeothermometer (Oxygen and  Deuterium isotopic contents). This study will be based on the direct simulation of the isotopes in GCMs, and  will include the use of finer grid GCMs (NASA/GISS, LMD and ECHAM model versions).  Mechanisms responsible for North-South long term climate connections will be analysed with the LLN two  dimensional (zonally averaged) climate model. Specific questions that will be addressed are the role of the  external forcings, greenhouse gases, land-ice and sea-level connection etc. A relatively simple biospheric carbon  cycle submodel will be used to study feedback to the physical climate system. Explicit inc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a commercial manufacturing process for embeddable RFID and NFC Tags for complete lifecycle tracking of tyres' (OnTrack).

assistant: **Concept**

Europe’s tyre manufacturing and re-treading industries are under increasing threat from imported tyres mainly from China. The EU re-treading industry is valued at €1.2bn (2015) but is declining due to the influx of Chinese tyres leading to the loss of highly-skilled jobs.The low-cost imported tyres cost on average €80 per tyre compared to €300-500 from a premium manufacturer. The temptation to buy these low-cost tyres is clear, however they are manufactured from poor quality materials with tread patterns that underperform. The ethos of cheap tyres is ‘use and replace’, whereas premium tyres are built to be re-treaded to increase lifetime. As a result, imported tyres are not cost effective over the lifetime of the tyres due to poor fuel economy and performance. Use of premium tyres and re-treading over the use and replace model needs to be encouraged to increase safety and fuel efficiency.Silent Sensors are an innovative IoT company that are working on a tyre traceability solution to remove the logistical burden of re-treading for FOs. We are manufacturing UHF/NFC RFID tags ‘OnTrack’ to embed directly into tyres which provides each tyre with a permanent, unique ID for life. Our tags can store data from the manufacturing process and key events during operational use such as repairs etc. This comprehensive history for each tyre makes it easier for FOs to plan their tyre re-treads. This data also makes the re-tread process simpler as the tyre history will speed-up integrity tests.OnTrack is the only tyre traceability solution that offers NFC – empowering employees to interrogate tyres with just a smartphone. We have a clear market opportunity with OnTrack to supply up to 40m tags/annum to a single tyre manufacturer. Based on our 7-year cumulative total gross profits of €44.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Design and opreation of hot water systems and application for on site electrochemically generated chlorine dioxide for control of legionella'.

assistant: **Innovation**

In resent years the outbreaks of Legionnaires' disease have been reported from most of the European countries (1442 cases in 1998). The objective of this project is to reduce the rate of infection in Europe by development of new innovative methods and equipment which can reduce the energy demand by combining temperature variations with other disinfections methods for controlling the growth of Legion Ella in hot water systems. Design and operation of hot water systems combined with innovative disinfections treatment processes such as electrochemically generated chlorine dioxide will eliminate the need for site storage of disinfectants. The effect of temperature schemes and disinfections treatments bio film will be investigated by field studies at critical end users such as hospitals, health institutions, hotels and bigger apartment buildings. The results will contribute to the existing knowledge and improve the practical use of disinfectants to prevent the growth of Legion Ella.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Colloidal suspensions in non-ergodic states'.

assistant: **Concept**

COSINES aims at transferring knowledge in the inter-disciplinary area of colloid science. This will be achieved through implementation of a specific research topic relating to the investigation of non-ergodic states in colloidal systems (glasses and gels), both in quiescent conditions and under stress.This represents one of the foremost challenges in soft matter science and is manifested in several practical applications such as production and time stability of consumer products, as well as the function of biological systems. In this context we seek an understanding of the rheology of such frustrated states and their relation to the microscopic dynamics and ageing. For this reason we propose to study model systems with varying interparticle interactions from hard sphere colloids to ultrasoft core-shell or microgel particles and explore their role in the non-ergodicity transition and the mechanics.To reach its goal, COSINES will use a combination of experimental techniques available at the Host Institution and develop novel ones. A crucial element of this methodology is the interpretation of the experimental findings that will involve a synergism with theory and computer simulations. The key to the successful completion of the proposed transfer of knowledge in COSINES is the collaboration with the identified leading experts from European groups in all-relevant aspects of research and training.Therefore, several exchange visits for joint research and tutorial lectures throughout this project are envisaged. COSINES aspires at establishing the Host Institution as a European Center of Excellence in Colloid and Soft Matter Research that will provide both academic and applied services in the entire region of southeast Europe. Thus, COSINES will promote integration and competit