RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of Mitochondria-Associated ER membranes on microglia activation: implications for Alzheimer's disease.' in the context of a Horizon Europe call.

assistant: **Objectives**

Alzheimer’s disease (AD) is an irreversible neurodegenerative condition affecting 50 million people worldwide. Despite intense research, the pathological mechanisms of AD are still unclear. Many genetic loci robustly associated with AD code for proteins that are preferentially or exclusively expressed in microglia, supporting a causal role of microglia as key players in disease initiation and progression. Microglia are brain-resident immune cells that, upon activation, reorganize their cellular membranes by coordinating a network of lipid pathways at unique subcellular regions localized in the endoplasmic reticulum, called MAMs (Mitochondria-associated ER membranes), the membrane contact site between ER and mitochondria. Hyperactivation of MAM is shown to be associated with AD pathogenesis, however, the impact of MAM alteration on microglia biology is unexplored. The main objective of INFLAMAM is to determine the mechanism by which MAM regulates microglia activation, and the impact of defects in MAM and lipid homeostasis in the context of AD. To that aim, we propose to combine cutting-edge lipidomics and proteomics approaches with pharmacological and genetic MAM intervention strategies to identify relevant molecular drivers that enable the crosstalk between lipid metabolism and immune signaling at MAM in microglia. By proving the role of MAM as an immunometabolic hub for inflammation and a driver of AD pathogenesis, we believe this innovative project has the potential to pinpoint relevant lipid pathways as new targets for pharmacological intervention to alleviate the symptomatology related to microglia in AD.


**Keywords:** mitochondria-associated ER membranes, lipid metabolism, microglia, inflammation, Alzheimer's disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Tactile Interactive Multimedia Computer games for visually imparied children'.

assistant: **Objectives**

TIM is intended to conceive computer games usable by young blind children in an autonomous way, without assistance of a sighted person. TIM games can be used by children of various levels of psychomotor development who cannot use the keyboard (young children or children with multiple disabilities). The software has a ludic and educational role. For children with additional disabilities, like cognitive troubles, it can have a therapeutic role. TIM allows to adapt existing commercial computer games (reusing rich audio resources, with coherent educational and ludic contents) and to develop specific contents (fitting special needs of young blind children). The European dimension allows to reach the critical mass necessary to consider a realistic commercialisation, allowing TIM games to access end users: children. In that way the software is made to develop the games simultaneously in several languages.DESCRIPTION OF WORKThe project will be achieved in 3 phases: During the first phase a Users Needs Report, based upon data collected during an inquiry and a workshop assembling researchers and professionals working with visually impaired children; a script language allowing to describe the scenario of games will be specified; and a software will be developed including several independent components dedicated to each kind of device (tactile boards, sound displays, speech synthesisers, Braille displays), an interpreter for the TIM language, multilingual features. The second phase will start by a semiotic analysis of existing games. Then several sets of games will be developed, corresponding to different kinds of children, according to the Users Needs Report. It will include the study of the different kinds of technologies usable to make the tactile adaptation sheets for TouchPads
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Era-Net Materials - a Preparatory Phase' (ENMATSSA) under Sixth Framework.

assistant: **Objectives**

The target of this specific support action (SSA) is to prepare an ERA-NET proposal on the area of materials science and technology called ERA-NET Materials". With this "ERA-NET Materials" project the bases for durable European partnerships in RTD planning and collaboration on materials science and technology will be strengthened. Also, systematic working methodologies from general science and technology policy to practical operations will be developed. As a result, regional and national programmes in member countries and regions will be gradually opened. This "ERA-NET Materials" activity will effect in the long run on the general impacts on the policy making behaviour of the participant countries and regions. The general knowledge on materials RTD based both on materials science and materials technology can be gathered more easily through common and generic RTD actions from the network. With the active networks the key players and the level of materials RTD activities in each country can be easily established. Also, the networking activities will help to identify those materials RTD areas in which each country should invest nationally. Based on that, the national materials RTD activities can concentrate on the most essential themes or actions which will be chosen according to the national needs. Closer collaboration of national and regional actors operating in materials science and materials technology will also increase the industrial utilisation of knowledge in Europe. This specific support action will be started by key policy making organisations from potential small European countries creating at the first stage a critical mass for the action. During this action the group will be enlarged to include also the main policy makers from some larger countries according to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Artemisinin-based combination therapy: an illustration of the global pharmaceutical drug market in Asia and Africa' (GLOBALMED).

assistant: **Concept**

Pharmaceutical drugs provide an ideal window into studying contemporary societies. With dimensions that are simultaneously scientific, therapeutic, popular and commercial, these drugs are central to various issues. ACTs, the new recommended treatment for malaria in Africa, crystallize these issues and provide a case study to investigate the global drug market. This project proposes to use ACTs as a lens to study the realities affecting this market, both in terms of supply and demand in two African countries where the pharmaceutical systems differ significantly. This will involve analyzing the globalizing processes affecting drugs in Benin and Ghana and to study their consequences on public health. To further compare the drug systems and to address the serious issue of the spread of resistances to ACTs from Asia to Africa, the project also proposes conducting a study on the drug system in Cambodia. The central discipline is anthropology, which is extremely relevant to the study of formal and informal pharmaceutical supply and to the analysis of drug use (WP1 and WP2). However, since a multidisciplinary approach is advised for drug studies, the PI will work with an epidemiologist who will study the scope of ACT consumption (WP3) and a sociologist specializing in pharmaceutical legislation who will analyze local production and ACT regulations (WP4). Opening into Asia will occur through WP5. A WP6 is devoted to project management, dissemination of results, organizing two symposiums and institutional twofold impacts: (1) to foster reflection so that more efficient pharmaceutical systems are established in Africa, and (2) to provide critical information to prevent the spread of resistances to ACTs from Asia to Africa. The project includes a substantial training component: 8 m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Re-fashioning the Renaissance: Popular Groups, Fashion and the Material and Cultural Significance of Clothing in Europe, 1550-1650' in the context of a Horizon 2020 call.

assistant: **Objectives**

This study of Renaissance dress offers a better understanding of how fashion developed at popular levels ofsociety in Europe, 1550-1650. Drawing on documentary, visual and material evidence, it investigatesfundamental questions relating to the transformation of fashion that will shed light on popular taste,dissemination, transformation and adaption of fashion, on imitation and meaning, and on changing culturalattitudes to dress among popular groups. The central goal of the project is to develop a new methodology thatcombines my previous experience of empirical research and theoretical models with the tradition of textileanalysis and costume conservation. This involves experimenting with a range of techniques, includingtechnical analysis of textiles, dye- and fibre analysis, and the reconstruction and visualization of historicalfashions using both 16th-century recipes as well as modern digital tools such as 3D printing and digitalreconstruction. This framework of dress and textile history at both scientific and experimental levels helps meto provide a more comprehensive interpretation of the value, variations, and material experiences that wereassociated with dress and dressing in the Renaissance, and to develop methodologies that allow us to explorenew ways in which narratives from historical documents, books, images, and material objects can be created.The new historical knowledge and methodologies built during the ERC will lead to the ultimate theoreticalobjective of the project –to rethink the scientific foundation and theory of dress studies within the ‘newmaterialist’ framework. By creating a material-based approach and methodologies to the study of fashion in thecontext of popular groups, my research will not only build new horizons for the study of popular dress
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Swift GRB Host Galaxy Legacy Survey: Understanding the Link between GRBs and Star Formation from the Nearby to the Early Universe' (SHOALS) targeting Horizon 2020.

assistant: **Abstract**

I propose to carry out the Swift Gamma-Ray Burst Host Galaxy Legacy Survey (SHOALS), a multi-national, multi-facility, multi-wavelength eﬀort to characterize the gamma-ray burst host galaxy population and how it connects to other star-forming galaxy populations at high redshift. Gamma-ray bursts represent invaluable tracers of the conditions in distant galaxies and provide a unique means of measuring the contribution of the faintest and highest-redshift galaxies to stellar mass assembly, yet we still do not understand what their progenitor system is or what environmental inﬂuences cause GRBs to explode more frequently in certain types of galaxies than others. By intensively charactering a large population of uniformly-selected GRB hosts across cosmic history, I will disentangle the various factors that may inﬂuence GRB production (chemical composition, starburst intensity, population age) and apply these results to better understanding how these violent explosions are produced and how we can use them to better understand the earliest phases of galaxy evolution.


**Keywords:** Star-formation,  gamma-ray bursts,  galaxies,  early universe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'The genetic basis of gyrodactylus salaris resistance in atlantic salmon (SALMO SALAR)'.

assistant: **Objectives**

Non-Baltic European Atlantic salmon stocks are faced with extinction from inadvertent introductions of the ectoparasite Gyrodactylus salaries. Many stocks in Norway are already extirpated. Current management options, based on rotenone, are only partially effective and environmentally destructive. The project will develop new management options through molecular studies of the genetics of host resistance and parasite pathogen city. The genetic-genetic basis of the host-parasite interaction will be investigated and molecular markers for resistance genes in a salmon and for pathogen city in G. salaries identified. Resistance markers will allow selective enhancement, or breeding in of heritable resistance into, salmon stocks providing a permanent solution to infestation. Pathogen city markers will help document the biogeography of pathogenic forms and allow development of more effective measures for parasite control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sequence-Enabled Single cEll Identification device' to be submitted under Horizon 2020.

assistant: **Abstract**

The dynamics of cell populations within tissues and organs is a hallmark of multi-cellular organisms. In many pathological states (e.g. cancer, diabetes etc) the functions and quantities of specific cell populations change. The ability to simultaneously and effectively monitor these functions and changes is essential for the study of these pathologies and the development of diagnostics and treatment. While single cell profiling is a multi billion dollar market, currently, unbiased and comprehensive classification of tissues into well-defined and functionally coherent cell subpopulations is impossible due to limitations in technology. Here we propose commercialize a technology we recently developed and published (Jaitin et al  Science 2014) - Sequence-Enabled Single cEll identification (SENSEI) - based on massively parallel sequencing of RNA from single cells. Using broad sampling of single cell functional states from multi-cellular tissues we reconstruct biological functions in a bottom-up fashion, starting from the most basic building block – the cell. The potential benefits of this invention are blatantly evident. Since cells are the basic building blocks of multi cellular organisms accurate and dynamic description of cell states and functions is essential for both basic biological research and personalized medicine clinical applications. Our technique is immediately applicable in molecular biology labs, clinics or industry, requires no specific equipment beyond our developed consumables and can provide data on RNAs from hundreds of single cells at the cost of one standard average gene expression profile. Massively parallel single cell RNA sequencing is therefore emerging as a super high-resolution, robust and affordable approach for unbiased functional characterizati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Engineering Solutions for the Process Industry', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Engineering Solutions for the Process Industry: The overarching research theme of the PROCESS Fellowship Programme is Advanced Manufacturing of high value products and engineering solutions for related industries, with particular emphasis on particulate product processing for new products within the dairy and pharmaceutical sectors. A broad range of research focus areas are envisaged, incorporating process modelling and integrated process control, with associated Process Analytical Technologies (PAT), heat, mass and momentum transfer, hybrid processing and subsequent smart data management, to promote processing agility and flexibility within an Industry 4.0 framework.PROCESS will run for 60 months, and will fund 26 experienced researchers of any nationality across two competitive Calls for Proposals for European Fellowships (two-year). The successful applicants will be awarded an employment contract in Ireland with the host beneficiary University of Limerick, and will have the option of selecting supervisors from any of the three participating Centres (Dairy Processing Technology Centre - DPTC, Synthesis and Solid State Pharmaceutical Centre - SSPC, and Pharmaceutical Manufacturing Technology Centre - PMTC) within the University. Fellowships will include mandatory secondments (between 3 to 6 months) to industry, with placements selected from, but not limited to, dairy and pharmaceutical companies who are partners of the three Centres.  It is expected that these placements will be beneficial to the candidate’s research and training project. To facilitate this, the participating Centres have already secured the commitment of leading companies, and other internationally recognised research centres, to host Fellows on secondment. Projects proposing fundamental or applied re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biogas robust processing with combined catalytic reformer and trap' (BIOROBUR).

assistant: **Innovation**

In the BioROBUR project a robust and efficient fuel processor for the direct reforming of biogas will be developed and tested at a scale equivalent to 50 Nm3/h production of PEM-grade hydrogen to demonstrate the achievement of all the call mandates. The system energy efficiency of biogas conversion into hydrogen will be 65%, for a reference biogas composition of 60%vol CH4 and 40%vol CO2.Key innovations of the BioROBUR approach are:- The choice of an autothermal reforming route, based on easily-recoverable noble-metal catalysts supported on high-heat-conductivity cellular materials, which shows intrinsic advantages compared to steam reforming: catalysts less prone to coking, easier adaptability to biogas changing composition, more compact design, efficient handling of heat, lower materials costs, fast start-up/shut-down, easier process control, etc.- The adoption of a multifunctional catalytic wall-flow trap based on transition metal catalysts, close coupled to the ATR reformer, which could entail effective filtration and conversion of soot particles eventually generated in the inlet part of the reformer during steady or transient operation, the decomposition of traces of incomplete reforming products (i.e. aldehydes, ethylene,…), the promotion of the WGS reaction to a significant extent so as to lower the size of the WGS unit, etc.- The adoption of a coke growth control strategy based on periodic pulses of air/steam or on momentary depletion of the biogas feed so as to create adequate conditions in the ATR reactor for an on-stream regeneration of the catalysts, thereby prolonging the operating lifetime of the catalysts with no need of reactor shut-down.Under the experienced coordination of Prof. Debora Fino, the project will integrate, in an industrially oriented explo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SIMBIO - A Generic Environment for Bio-numerical Simulation' (SIMBIO) under Fifth Framework.

assistant: **Objectives**

%Objectives:The SimBio project will produce a generic simulation environment for advanced clinical practice and health care. A key feature is the input of individual patient data to the modelling and simulation process. While future SimBio users will be able to develop application specific tools to improve practices in many areas, the project evaluation & validation will demonstrate improvements in: non-invasive diagnosis and pre-operative planning, design of prostheses and of the operative procedures for their implantation. The SimBio environment components are: discrete representation of the physical problem; numerical solution system; inverse problem and optimisation; visualisation. The SimBio environment will be designed for execution on parallel and distributed computing systems, component interaction aims to exploit CORBA. The compute-intensive environment components will be implemented on HPC platforms.Work description:The SimBio project will produce a generic simulation environment for advanced clinical practice and health care. This environment will be a highly innovative combination of: sophisticated medical imaging; high-level image processing; finite element techniques; parallel and distributed computing technologies. A key feature is the input of individual medical scan data to the modelling and simulation process.The SimBio environment will be comprised of the following components: Discrete Representation of the Physical Problem (Medical scan data is transformed into a finite element mesh and provides data for tissue modelling within the finite elements); Numerical Solution System (SimBio-internal parallel finite element solvers and numerical library routines will be provided, together with an interface to allow for external codes to interact with the SimB