RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Patented advanced low-cost multiwell cell-culture system for in-vitro physiologically relevant biomarker screening' under Horizon 2020.

assistant: **Concept**

Biomarkers in discovery are valuable tools to understand the pathobiology of a disease and the pharmacology of a target under investigation. In-vitro screen would be invaluable in identifying working hypothesis early in drug development process. Information provided by properly selected biomarkers can greatly influence a go/no go decision. The challenge is to identify relevant biomarkers early enough to implement them for such critical decisions.In developing in-vitro assays to identify biomarkers with potential clinical application and utility, a clear understanding and determination of what that biomarker will assess must be defined. More reliable biomarker screening protocols based on allometric scaling laws are needed to be implemented in order to gain results more respondent to human physiology. The predictive power of High Content Screening techniques can be enhanced by working with primary cells or differentiated stem cells and in 3-D culture. Nevertheless, in-vitro cell cultures are still far away from the complexity of human tissues or organs.IVTech intends to industrialize and test Multidyn, a patented advanced low-cost cell culture system made up by a 24-chambers plate complying with the multiwell standard, capable of any internal connection and flow within the cells, able to realize cheaper faster in-vitro physiologically relevant cellular systems. Multidyn will be tested for early diabetes biomarker discovery by using a developed model of liver, vascular endothelium and adipose tissues, and when equipped with the highly performing 3D scaffolds provided by the partner Scaffdex and with suitable High Content Imaging systems provided by the partner Celltool and selected scientific laboratories.IVTech’ Multidyn is at TRL 6. Phase 1 project will assess the activ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimized huMan iN vItro vascularized 3D Brain tissUe model for Studying neurodegeneration' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Neurodegeneration is a major health concern affecting millions of individuals in Europe, with this number constantly increasing as population ages. A cure for this spectrum of conditions is still missing, in part due to differences between available experimental models and human pathophysiology.My aim is to develop an in vitro 3D brain tissue model that combine the major brain cell types (obtained from human induced pluripotent stem cells - iPSCs) also including vascular cells, for better resembling the human brain. Currently, the available in vitro 3D brain tissue models lack a functional vasculature with brain-specific features, thus limiting the possibility to study (vascular-related) pathophysiology. Transplantation is still the only strategy leading to an extensive and functional vascularization of 3D brain models.I will combine -omics technologies for optimizing the vascularization of 3D brain tissue models. First, I will investigate whether factors released by iPSC-derived neurons and their precursor cells can promote vessel formation by the endothelium. Second, I will determine which changes occur in 3D brain tissue models upon transplantation compared with in vitro culture. I will then reproduce the identified drivers of this process for obtaining a fully in vitro vascularized 3D brain tissue model, without the need for transplantation. Finally, I will show that the manipulation of this vascularized 3D models allows for studying the vascular contribution to mechanisms of neurodegeneration and for evaluating possible intervention strategies.The optimization of in vitro vascularized 3D brain tissue models will facilitate reducing costs and number of experimental animals. Also, their ease of manipulation and high-throughput will facilitate mechanism investigation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Combinatorial Computational Chemistry   A new field to tackle environmental problems' (C3ENV) under Seventh Framework.

assistant: **Objectives**

Combinatorial Computational Chemistry is developed as a standard tool to tackle complex problems in chemistry and materials science. The method employs a series of state-of-the-art methods, ranging from empirical molecular mechanics to first principles calculations, as well as of mathematical (graph theoretical and combinatorial) methods. The process is similar as in experimental combinatorial chemistry: First, a large set of candidate structures is generated which is complete in the sense that the best possible structure for a particular purpose must be found among the set. This structure is then identified using computational chemistry. We will apply methodologies at different stages in hierarchical order and successively screen the set of candidate structures. Screening criteria are based on the computer simulations and include geometry, stability and properties of the candidate structures. Detailed characteristics of the final materials will be simulated, including the X-ray diffraction pattern, the electronic structure, and the target properties. We will apply C3 to two important problems of environmental science. (i) We will optimise nanoporous materials to act as molecular sieves to separate water from ethanol, an important task for the production of biofuels. Here, materials are optimised to transport ethanol, but not water (or vice versa). The tuning parameters are the channel size of the material and its polarity. (ii) We will optimise nanoporous materials to transport protons, an important task for the design of energy-efficient fuel cells, by distributing flexible functional groups, acting as hopping sites for the protons, in the framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Resilience-Increasing Strategies for Coasts - toolKIT' (RISC-KIT).

assistant: **Innovation**

Resilience-Increasing Strategies for Coasts – toolKIT (RISC-KIT) will deliver ready-to-use methods, tools and management approaches to reduce risk and increase resilience to low-frequency, high-impact hydro-meteorological events. The open-source and free-ware RISC-KIT tool kit will consist of ● a Coastal Risk Assessment Framework (CRAF) which - at the regional scale (100’s km) - can quickly assess present and future hot spot areas of coastal risk due to multi-hazards ● a quantitative, high-resolution Early Warning and Decision Support System (EWS/DSS) for use on these hot spots (with a scale of 10’s of km) and ● a web-based management guide offering innovative, cost-effective, ecosystem-based DRR measures; and ● a Coastal Risk Database of present and historic socio-economic and physical data. These tools will enable Europe’s coastal managers, decision-makers and stakeholders to ● identify hot spot areas; ● produce timely forecasts and early warnings; ● evaluate the effect of climate-related, socio-economic and cultural changes on coastal risk; and ● choose the best prevention, mitigation and preparedness measures for their coast. The toolkit will be tested using data collected on ten diverse case study sites along each of Europe’s regional seas and one international site. The toolkit’s performance will be evaluated with an End-User Board of coastal managers, civil protection agencies and local governments with a vested interest in each of these case study sites. The RISC-KIT products will help to achieve rapid attainment of UNISDR Disaster Reduction Goals and promote EU-consistent methods through innovative e-learning and open access publication. RISC-KIT will have an active synergy with Belmont Forum projects, related EU projects and an International Expert Board with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reclaiming professional identity: refugees’ challenges and supports with re-entering the teaching profession in Norway' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Despite Norway's role as a major refugee-hosting context, little is known about refugee-background teachers' experiences with professional reintegration in the country. This reflects a wider European gap in research and practice, despite EU goals of refugee inclusion. The RE-TEACH project addresses this gap by examining the challenges and supports which shape teachers' return to the classroom, with a focus on professional identity, agency and intersectionality. The project has three objectives: (1) to synthesise European knowledge on refugee teachers' reintegration through a systematic review of academic and grey literature; (2) to generate in-depth, multimodal data on refugee-background teachers' lived experiences in Norway via a participatory case study; and (3) to produce evidence-based recommendations for policymakers and practitioners at local, national and EU levels. These objectives will be pursued through interdisciplinary methods spanning sociology, education and migration studies, in close collaboration with a refugee-serving organisation.The project centres refugee-background teachers' voices through interviews, focus groups and digital diaries, applying constructivist grounded theory to analyse how reintegration pathways are shaped by both structural and personal factors. It advances theoretical work on professional agency and identity, while informing policy innovation in credential recognition, employment support and inclusive school practices. Led by a researcher with extensive expertise in refugee education, migration and inclusion, and hosted by the Centre for the Study of Professions (SPS) at OsloMet—an institution with strong competence in labour market inequalities and professional integration—RE-TEACH promotes more equitable and effective reintegrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Additive Manufacturing of Living Composite Materials'.

assistant: **Objectives**

I envision a world in which the responsive power of biological systems is harnessed through direct integration in materials and structures. Biological materials constantly adapt to their environment, display lower embodied energy, and possess remarkable mechanical properties granted by their hierarchical structures. Adapting these principles to human-made objects promises to disrupt the way we engineer our high-performance critical structures. However, todays engineering materials remain lifeless, and show only limited abilities to adapt and reinforce under load, or to heal and repair in response to damage. By addressing the lack of knowledge in (i) organism signalling, (ii) additive fabrication and (iii) responsive bio-inspired composites, I will be amongst the first to create living composites that will bridge the gap between biology and stiff, lightweight engineering structures.To achieve my vision of living structures, I will cross boundaries between three previously disconnected disciplines. I will (i) exploit the intrinsic electrical activity of fungal mycelium networks to couple electrical and mechanical response in mycelium composite materials, (ii) enable complex shaping using new additive manufacturing technologies to create bio-inspired living objects augmented with sensing and vasculature networks, and (iii) develop topology optimised geometries and large-scale living structures that adapt and remodel during use. The project combines these aspects to exploit organism growth and function in a way never done before to realise stiff, tough, and responsive materials, while paving the way for a future of living material structures.


**Keywords:** additive manufacturing, bio-inspired composites, living materials and structures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Artificial intelligence enabled electrospinning approach to fight pulmonary cancer' (RESPIRE) targeting Horizon Europe.

assistant: **Abstract**

Pulmonary cancer is the leading cause of cancer deaths worldwide. Surgery is associated with high morbidity and operative mortality. One of the main causes of the poor survival rate is cancer relapse at the surgical resection margins. Thus, developing a strategy to minimize the local recurrence rate of lung cancer efficiently is greatly needed. Nanotechnology-assisted approaches, such as nanoparticles (NPs) and nanofibers (NFs) obtained via electrospinning could enable novel strategies to fabricate better performing implantable devices, including localized drug delivery systems. Many working parameters affect the final outcomes in electrospinning and different fibrous architectures can be generated, much is still to be understood to precisely control, and ultimately predict the mechanical, physico-chemical, and bioactive properties of the resulting meshes, which are essential in pulmonary tissues. The Postdoctoral Fellowship Researcher (PFR) has studied biodegradable fibers as drug delivery systems in her Ph.D. and Post Doc and herein aims to develop a biodegradable nanofibrous patch based on elastin (i.e., the native component of the pulmonary tissues) containing chemotherapeutics via electrospinning/electrospray. To achieve this ambitious goal, the PFR needs to learn multiscale materials design and artificial intelligence to precisely match the mechanical properties of lung tissue, which will be addressed during the outgoing phase at MIT. PFR will also investigate the encapsulation of chemotherapy and immunotherapy inside electrosprayed NPs, will model release mechanisms at MIT and will analyze drug release effectiveness in an in vitro model at UTRGV (i.e., secondment) to be used for a biologic assessment in the returning phase at the UNIPI. The multidisciplinary appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Imaging the cosmic dawn and the first galaxies with 21cm and atomic line intensity mapping', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Modern astrophysics has pushed the observational frontier to a time a billion years after the Big Bang.  Lying beyond this frontier is the period when the first stars and galaxies formed, whose light heated and ionized the Universe in the process known as reionization.  Understanding this ""epoch of reionization"" would fill in a key missing period in our picture of the history of the Universe.  Existing observational techniques have scratched the surface, but new observational techniques are required to truly understand this early period of galaxy formation.  My work will lay the theoretical foundations for three novel probes of this period - 21 cm tomography, the 21 cm global signal,  and line intensity mapping - that would enable three dimensional maps of the epoch of reionization.  If realized through challenging radio-frequency observations, these techniques would transform our understanding of the first galaxies.Through this ERC starting grant, I will build the theoretical framework needed to predict and interpret observations of line emission from gas in and surrounding the first generation of galaxies.  My team will aim to develop models of the interplay between radiation from the first galaxies and the heating, ionization, and illumination of hydrogen gas that lies in the space between galaxies.  At the same time, we will build models of the formation and properties of the atomic and molecular gas that fills the space inside galaxies.  By combining probes of this ""inner"" and ""outer"" space a complete nature of galaxy formation during the first billion years might be achieved. Analysis of sky averaged 21 cm observations will complement this with a broad overview of galaxies back to a few hundred million years after the big bang. This work will provide a clear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Paris Natural History Museum's Systematics Collections (PARSYST)' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Principal characteristics of the facility and of the support offered to users: The Large Scale Facility for Systematics, Taxonomy and biodiversity studies in the Museum National d'Histoire Naturelle, Paris, includes the 15 laboratories holding the reference collections covering the whole spectrum of animal and plant realms, present and past. These collections, most of them unique, represent more than 80 Million specimens among which 700.000 taxonomic types. It is one of the three most comprehensive facilities of this type in the world and the oldest professional collection ever built up. A team of 143 curators and 110 research associates, all of them trained scientific experts is allowing a high quality scientific support. Together with access to reference specimens the visiting scientist will have at his disposal a series . of specialised libraries and the curation documentation attached to each collection. This information system is completed by a Museum Main Library (with extensive old and recent scientific litterature). Support staff will ensure technical assistance and a series of scientific equipments are available for various types of investigation in Natural History, even the more recent ones (cytology, molecular systematics, morphometrics, computerised phylogenetic analysis, statistical tools, optic and electronic microscopy).The visiting scientist will benefit of a direct access to the internal computerised communication system with e-mail, on-line databases (both internal and external) and internet services. This facility, integrating 15 components is considered as a single equipment. It is supervised and coordinated by a steering committee with one person-in-charge. Within this frame the elected visiting scientist will have a high degree of autonomy in his r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Factorization Theory in Matrix Rings' (FacT-in-MaRs) under Horizon 2020.

assistant: **Objectives**

The characterization of integral domains R such that every singular matrix over R is a product of idempotent matrices is a classical open problem in ring theory. Its importance lies in the inter-connections with other big unsolved issues: classify integral domains whose general linear groups are generated by the elementary matrices, and those fulfilling weak versions of the Euclidean algorithm. The study of idempotent factorizations in matrix rings has gained increasing attention over the years and all the results have highlighted how the decomposition into idempotent factors is far from being unique.The Factorization Theory (FT) is the branch of ring theory that studies nonuniqueness of the representation of non-invertible elements in rings or semigroups as products of generating (irreducible) elements. Originated in the late 1960s, FT got in the last decade new striking developments (especially in the non-commutative framework) that, however, just barely involved matrix rings.The goal of FacT-in-MaRs is to study the nonuniqueness phenomena of idempotent matrix factorization from the point of view of the FT, thus connecting in an original way two areas of ring theory remained unrelated so far.In the framework of the present action, we aim at advancing the state-of-the-art by:1) defining a new concept of factorization into idempotent (non-irreducible) factors in the non-commutative semigroup of singular matrices over a domain R; 2) studying the nonuniqueness of this factorization in terms of arithmetical invariants (i.e., sets of legths/distances, elasticity);3) exploiting the previous results to provide new approaches to the classical problems on factorizations in matrix rings.The above objectives will be achieved through an innovative combination of classical and rece