RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Human reaching and grasping - cognitive networks of visual action control' under Seventh Framework.

assistant: **Concept**

Cognitive Neuroscience throughout the last decade was dominated by a two stream model of visual processing. A ventral pathway was presumed to be dedicated to perception-related processing. A dorsal pathway was presumed to be dedicated to action-related processing. The proposed project challenges this view combining neuroimaging and neuropsychological methods. Neuroimaging in healthy humans allows for a view on correlated activity of the intact perception-action system, patients with visuomotor deficits reveal causalities between perception- and action-related information processing and the demonstration of neural reorganisation. However, neuroimaging studies including patients with brain lesions have rarely been conducted. Patients with optic ataxia after brain damage demonstrate specific visuomotor disorders: (i) deficient grip scaling to object size and (ii) spatial mismatch between perceived positions and goal-directed hand movements. These deficits vary with temporal parameters and knowledge about the object to be grasped and/or manipulated. Furthermore, the patients seem to adopt cognitive strategies to improve their performance. Therefore, they allow for the investigation of interactions between visual perception, spatial memory, and cognitive processing for the purpose of goal-directed action control. The proposed project comprises behavioural experiments to reveal the impact of object/action knowledge on movement control and of movement timing in optic ataxia patients. Investigations of reaching and grasping using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation in healthy subjects and patients complement the neuropsychological research approach. The analysis of specific activation patterns and behavioural changes upon TMS appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'ENVIRONMENT CONTROL SECONDARY SYSTEM'.

assistant: **Concept**

The Environment control system plays a significant role in guaranteeing air quality and thermal comfort in the aircraft cabin. Nevertheless, standard ECS remains one of the main power consumer function in the aircraft. Our EC2S solution proposes to reduce the need of fresh flow from 70% to a much lower percentage by recycling and treating cabin air, downsizing the ECS system weight, fuel consumption, pollution and costs. Our ambition is to design the first Air Recirculation System (named EC2S Environment Control Secondary System) by integrating the smartest Air treatment processes and Sensors and demonstrate its efficiency and certifiability on the CS2 regional aircraft ground demonstrator.  The Consortium - made of Hutchinson (coordinator, and world leader for ECS solutions in Aeronautic domain), Ecologicsense and Tera Environment (SMEs specialized in sensors and air quality monitoring), and a research center (CEA, working on indoor air treatment) - presents complementary skills to the success of the project. This solution is based on four main pillars: •A multi-technology approach for Air treatment, covering the largest Temperature / air flow conditions   •World class sensors transferred from the automotive industry, ensuring reliability and cost •A compact EC2S pack that can be easily connected to a “in service” aircraft ECS system  •A common monitoring system to split the ECS function between the primary ECS and the secondary based on the optimization of fuel consumption.      The innovation potential of the project goes beyond the call objectives by providing a more comprehensive on-line monitoring chain of the air quality of the cabin and by its capacity to trap CO/CO2.   The consortium will ensure demonstration of the system both in laboratory and cabin demonstra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Spatial organization of DNA repair within the nucleus' to be submitted under Horizon 2020.

assistant: **Abstract**

Faithful repair of double stranded DNA breaks (DSBs) is essential, as they are at the origin of genome instability, chromosomal translocations and cancer. Cells repair DSBs through different pathways, which can be faithful or mutagenic, and the balance between them at a given locus must be tightly regulated to preserve genome integrity. Although, much is known about DSB repair factors, how the choice between pathways is controlled within the nuclear environment is not understood. We have shown that nuclear architecture and non-random genome organization determine the frequency of chromosomal translocations and that pathway choice is dictated by the spatial organization of DNA in the nucleus. Nevertheless, what determines which pathway is activated in response to DSBs at specific genomic locations is not understood. Furthermore, the impact of 3D-genome folding on the kinetics and efficiency of DSB repair is completely unknown.Here we aim to understand how nuclear compartmentalization, chromatin structure and genome organization impact on the efficiency of detection, signaling and repair of DSBs. We will unravel what determines the DNA repair specificity within distinct nuclear compartments using protein tethering, promiscuous biotinylation and quantitative proteomics. We will determine how DNA repair is orchestrated at different heterochromatin structures using a CRISPR/Cas9-based system that allows, for the first time robust induction of DSBs at specific heterochromatin compartments. Finally, we will investigate the role of 3D-genome folding in the kinetics of DNA repair and pathway choice using single nucleotide resolution DSB-mapping coupled to 3D-topological maps.This proposal has significant implications for understanding the mechanisms controlling DNA repair within
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Marseille and the (Im-)Mobilities of Black Maritime Workers in the African Mediterranean' (Im-), addressing dissemination and exploitation.

assistant: **Impact**

“Marseille and the (Im-)Mobilities of Black Maritime Workers in the African Mediterranean” (MIBWAM) is an interdisciplinary and intersectoral project dedicated to illuminating Africa’s place in the global history of labour, port cities, colonialism and world oceans. The objective of the research, under the supervision of Prof Xavier Daumalin (AMU/TELLEMe), is to uncover the intersections of docks and decks in the life of African maritime workers within the French empire, which subverts common narratives of early globalization as an age of borderless circulation. The results will greatly impact the international debate on global social history. Furthermore, from the vantage point of the (im-)mobilities of Black maritime workers in Marseille, the project conceptualizes a modern history of the “African Mediterranean” as a way of obtaining a more integrated view of the Mediterranean world. This cutting-edge interdisciplinary endeavour can greatly advance the crucial transregional reconceptualization of areas studies. Finally, MIBWAM seeks to engage a wide range of publics in reflection on the entanglements of Africa and the Mediterranean, which will both influence non-academic audiences and diversify my skills. To achieve these objectives, MIBWAM adheres to a multi-methodological approach including archival research, and includes a research blog devoted to citizen science and involving a variety of participants. An additional non-academic placement at MuCEM, a museum devoted to the Euro-Mediterranean world, is intended to revisit its representation of Africa, enriching its collections and databases destined to inform exhibitions. MIBWAM will thus foreground the neglected topic of Africa’s relevance to the Mediterranean region in both the academic and museum sectors. In acco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart Aircraft in Emergency Situations' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Ditching analysis is requested for large transport aircraft by EASA. The respective requirements are specified under § ‘’CS 25.801 Ditching’’. They are primarily devoted to a minimisation of risks for immediate injuries and the provision of fair chances for an evacuation. A significant part of average air travel is over water and historically a planned or unplanned water-landing event occurs grossly speaking every 5 years.This proposal directly addresses areas ""7.1.3.3: Aircraft Safety"" and “7.1.4.1: Aircraft Development Cost”.  The primary outcome of the SMAES project will be advanced methodologies and simulation tools to support aircraft development from pre-project phase to certification.  These will enhance future innovation in aircraft design through ensuring that innovative designs are compliant with safety requirementsThe key developments addressed in the work programme are:1.Improved models for the calculation of ditching loads including both analytical and detailed fluid dynamics models.   Inclusion of the effects of the complex flow physics in ditching is critical to prediction of ditching loads.2.Reliable and predictive aircraft models for structural behaviour under dynamic fluid loads.3.Demonstration of the methods on representative future aircraft design concepts.The consortium brings together aircraft manufacturers, analysis software developers, research organisations and universities.  Together the partners form a strong team covering the required expertise in aircraft design, numerical methods and simulation, ditching analysis and supporting experimental methods to achieve the project objectives.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Prediction of pressure vessel integrity in creep hydrogen service' (1994-1998).

assistant: **Concept**

Steels and weldments mechanical properties- Materials and components feasibility in Europe.- The strength of the materials is mainly dependent on the Tempering Parameter (resulting of the cumulative softening effect of both tempering and PWHT). A maximum value of TP=T (20+logt) will be of 21 000 for V-modified 21/4 and 3Cr1Mo steels.- The creep properties fall in the scatter band of reference curves for all material tested.- The sensitivity to Temper Embrittlement (as evaluated by the Charpy V curve after step cooling) was found to be very low for all six materials tested, in relation with low values of J-factor.- Base materials of the new V-modified 21/4, 3 and 9Cr 1 Mo were successfully manufactured by European steel makers as very thick products.- Filler metals convenient for the welding of V-modified materials were made available in industrial conditions by the two European manufacturers involved in the research and welding and post weld heat treatment recommendations have been proposed.Hydrogen effect (with or without stress):- Autoclave exposure of specimens (without stress applied) performed in the temperature range of 575 to 650°C with time up to 4000 hours permitted to rank the steels in the following order with decreasing susceptibility:a) Standard 21/4 Cr 1 Mo steel (sensitive)b) V-modified 21/4 Cr 1 Mo steels (low sensitvity)c) V-modified 3 Cr 1 Mo steels and V-modified 9 Cr 1 Mo steel (not sensitive).In addition, it was clearly observed that the fine grain area of HAZ presents the highest hydrogen damage for all materials.- Creep tests performed in hydrogen environment showed that:1. creep rupture time and creep ductility of standard material and welds were drastically reduced, out of the code lower limit.2. the susceptibility to hydrogen is in accordance w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stochastic thermodynamics of biochemical replication' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The main goal of this project will be to construct a thermodynamically consistent comprehensive model for biochemical replication using stochastic thermodynamics and control theory.I will subjugate the process of kinetic proofreading (KPR) to several thermodynamic bounds that have recently been discovered, in order to study the thermodynamic performance of this process. This will be done by considering the process as a chemical reaction network where a sequence of irreversible steps consume energy to increase replication accuracy and are hence bounded by fundamental no-go theorems such as the thermodynamic uncertainty relation (TUR) or the thermodynamic speed limit (TSL). I then investigate how the topology and reaction rates of the KPR network can be optimized with respect to error rate and dissipation by means of machine learning, to deduce how close biological systems operate to these bounds. Subsequently, I will extend the results to the conformational proofreading (CPR) process, where an energy handicap is added to the free energy to increase binding specificity at the expense of binding affinity. The CPR is a proofreading scheme that does not consume energy by burning ATP/GTP, so the entropy production has its origin in the conformational change.Finally, I test the robustness of the aforementioned KPR and CPR networks. In realistic systems, the kinetic rates can fluctuate as a consequence of e.g., temperature or chemical density variations, which can possibly destabilize the network and lead to more errors in the replication process. This will be done by considering the networks as input-output systems that can be studied by control theory. This provides fundamental bounds such as Bode's sensitivity integral to complement the TUR and TSL. I expect that the researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DRone European AIM Study', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The DREAMS project aims at contributing to the definition of the European UTM  Aeronautical Information Management operational concept by exploring need for and feasibility of new processes, services and solutions for the drone aeronautical information management within the new UTM concept. The UTM is seen as the key enabling concept for safe integration of drones within VLL  airspace, tailored on the needs of UAS operations. The study put together the knowledge of mission needs and operational requirements of drones commercial operators that want to make their operations safer and cost effective (BVLOS) with the knowledge of operating modes and procedures currently adopted by airlines and aircrew, general aviation associations and pilots, leisure/sport aeronautical activity associations and pilots, accessed information services, required data quality, resolution, temporality and services costs. The study will be focused not only to the needs of drones operators but will addressed the aeronautical information sharing requirements coming from the several stakeholders involved for different purposes in the drones VLL operation concept. The DREAMS study and its methodology are based on a deep competence in systems and technologies, currently used in the management of all types of air traffics, for flight planning, static and dynamic aeronautical Information and for airspace design and management. Operational and technical aspects, environmental scenarios, technologies, safety and security impact will be analysed in order to identify possible UTM data service providers (e.g. airspace structure, terrain, obstacles and weather,..) and facilities and the way this data service need to be tailored for UTM management service provision in order to allow quality and resilient infor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'STREAMLINED TEXTILE WASTE STREAMS FOR RECYCLING OPTIMIZATION' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

STREP ambition is to empower the European textile (recycling) industry with a solution for sustainable processing of textile waste by developing and rolling out of a novel and systemic waste sorting solution based on cost-efficient sensor and automation technology, self-learning AI, as well as a novel solution for textile disintegration and mechanical recycling. Furthermore, STREP develops chemical recycling solutions, to facilitate the production of a 100% closed loop recycled yarn based exclusively on post-consumer textile waste, creating a perfect balance between sustainability, cost, and quality. The overall ambition is enhancing European industrial sustainability, competitiveness, and resource independence through producing more sustainable products, while increasing consumer benefits.STREP integrates value chain, product quality, and environmental impact perspectives in its different phases. Two of the innovations are placed in the pre-consumer phases. One of these relates to developing and testing guidelines and matrix that can support product design phase, and implementing recycling-friendly assembly of textile products. The other one innovates the traceability of the products and the related waste to enable allocating different product (waste) streams to the right flows and processing alternatives. The rest of the innovations are positioned after the textile waste collection and include: technology for recognition and removal of hardware and prints as well as characterizing the waste (fiber length, humidity, dirt, etc.), developing innovative recycling methods based on solvolysis, enzymatic processing, pyrolysis and hydrothermal conversion to treat the appropriate textile waste fractions depending on the composition and the length of the fibers. Targeted produc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Feasibility study for the validation and industrialization of two diagnostic kits in both ELISA and CLIA formats for the early detection of pancreatic cancer based on the novel biomarkers EZR and ENOA' (EDePDAC).

assistant: **Innovation**

In this study we propose to investigate the feasibility of the industrial development and validation up to the CE marking of two immunodiagnostic kits based on two novel biomarkers recently identified as specific markers of early stage pancreatic cancer, Ezrin (EZR), and its treatment follow up, phosphorilated alpha-Enolase isoforms 1,2 (ENOA). The assays will detect antibodies to these biomarkers in blood. Pancreatic Ductal AdenoCarcinoma (PDAC) early detection is an unmet medical need in the developed world. Presently this cancer is the fourth leading cause of cancer-related death. The EZR kit, used alone on people at risk for PDAC, is proposed as a tool for an early diagnosis of pancreatic cancer. Blood positivity to both antibodies against EZR and ENOA is of great importance for a correct diagnosis of PDAC and the assessment of its development stage. Finally, the combined use of blood test for Ab-EZR, Ab-ENOA and CA19.9 should provides a robust tool for the general diagnosis of PDAC (100.0% sensitivity and 93.7% specificity). Te study will be conducted together with an expert and well introduced company in the field of IVD having a consolidated distribution network, that will support NatiMab in the assessment of the industrialization process and the market entering, and two companies which have the technical capabilities for the production of the two key components: EZR (GeNeuro) and ENOA (Iris Biotech). The IVD segment for PDAC early diagnosis and therapeutic assessment, including screening of population at risk, is a 3 billion potential market. NatiMab has the ambition to become a key player and first mover in such huge market. The final technological target of Natimab project is the development of a three-marker panel, including EZR, ENOA and CA19.9, which is exp