RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Centre of Excellence for Precise Phenotyping and BioDataBanking' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The vision of personalized medicine quickly materializes with increasing computational power employed for delineating the contribution of genetic and lifestyle factors to disease and therapeutic outcomes. However, to help a patient, it is essential to capture a disease status through detailed insight into individuals’ biomedical profile, now enabled thanks to AI-based solutions for big data integration. The access to necessary emerging technologies is currently hampered in many Central-Eastern Europe countries due to an immature culture and insufficient networking of main actors of the R&I sector. The objective of this project is to establish P4Health: a Centre of Excellence for Precise Phenotyping and BioDataBanking, based on the solid foundations of Lukasiewicz-PORT in Wroclaw, Poland. The design of P4Health is rooted in a complementary expertise in preclinical and clinical studies contributed by advanced partners, CERBM (France) and King’s College London (UK). In P4Health, partners will unify existing resources into a coherent workflow combining participatory biobanking, advanced diagnostics, and comprehensive validation of therapeutic strategies in cancer and brain disorders. This synergy will create pillars for new teams to efficiently generate essential data and translate them into economic and societal values. On a scientific level, P4Health will cause structural changes leading to a modernized and more competitive R&I sector in Poland and other Widening countries. On an economic level, P4Health will bring together scientists, clinicians, pharma industry and health case users for creating a forum for knowledge exchange, increased volume of commercialized IP and new business relationships. On a societal level, P4Health will become an expert center for regulatory b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Musical Imitation in Medieval Europe (1110-1300)' to be submitted under Horizon Europe.

assistant: **Abstract**

The project will study the cultural interrelations between sacred music and lay vernacular lyric by uncovering and analysing the melodic imitations that occur between the two repertoires. The research will focus on lyric, music, and manuscript sources produced in France and Occitania from the beginning of the 11th to the end of the 13th century, with the aim of understanding to what extent troubadour and trouvère poetry (which was always accompanied by music) depended on the Latin ecclesiastical cultural humus, its forms and its techniques. Imitation and memory were constitutive aspects of artistic creation in the Middle Ages, which was more often driven by an attraction for an established tradition rather than the perceived need for innovation. The project will exploit digital technologies available and develop new computational perspectives to analyse large corpora of liturgical and vernacular music in order detect concordances between melodies, with the aim of assessing the intertextual, literary and ideological implications of musical reuse. With this goal, the researcher will create a sophisticated searching tool able to detect similarities in melodic sequences which will take into account musicological principals as well as the variability inherent to the process of manuscript copy. A secondment period at McGill will enable the fellow to use Optical Music Recognition to enlarge the dataset of encoded melodies at an unprecedented speed and accuracy. This is expected to substantially increase the discovery of musical correspondences. The research will enhance our understanding of the dialectic between imitation and creation in the Middle Ages, and contribute to define the osmotic, yet conflicting, relationship between lay and religious culture and their creative env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Networking, partnerships and tools to enhance in situ conservation of European plant genetic resources' to be submitted under Horizon 2020.

assistant: **Abstract**

The overarching objective of Farmer’s Pride is to establish a network of stakeholders and conservation sites that effectively coordinates conservation actions to safeguard the wealth of Europe’s in situ plant genetic resources (PGR) and integrates the user community to maximize their sustainable use. Specifically, to address the challenge and scope of the SFS-04-2017 work programme, Farmer’s Pride will: a) build relationships between existing diverse PGR stakeholder networks, and where necessary create new partnerships to establish a unified network of stakeholders involved in PGR conservation and sustainable use; b) enhance existing knowledge of European landrace and crop wild relative genetic diversity and showcase how it can be effectively secured and managed; c) use social science and economic tools to establish the value of in situ PGR populations and individual traits, as well as a cost effective means of conserving them; d) use predictive characterization methods to identify valuable traits in in situ PGR populations, targeting those most vital for satisfying future agricultural and market needs; e) establish a mechanism to facilitate the flow of plant genetic material from in situ populations to the user community, both directly and via ex situ collections; f) develop and establish a durable governance and resourcing structure for the European network of in situ PGR conservation sites and stakeholders; g) promote public awareness of the value of PGR for agriculture and consumers; and h) design and implement a network of European sites and stakeholders that conserves the breadth of PGR diversity found in situ. Through these activities, Farmer’s Pride will result in significant strengthening of European capacities for the conservation, management and sustainable u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantum Coherent Control: Self–Interference of Electron Beams with Nanostructures' (NanoBeam), addressing dissemination and exploitation.

assistant: **Impact**

NanoBeam will develop new directions in electron microscopy, materials, and optical sciences to control and characterize the ultrafast responses of polaritons and electronic states in materials. This will be achieved by (i) a ubiquitous control of slow and fast electron wave packets and (ii) realization of fully coherent light sources using shaped electron wave packets interacting with nanostructures. Quantum coherent control traditionally employs a sequence of optical pulses to direct the response of condensed matter systems towards a desired state, as a tool for novel quantum technologies. This control system has been only recently implemented in electron microscopes, by combining lasers and photoemission electron guns. However, this field is still it its infancy because it does not provide us with important aspects of the sample response such as spectral phase and time-energy evolution of electronic states in samples, which happens at the attosecond time scale. NanoBeam aims at quantum coherent control within electron microscopes by triggering both electron wave packets and their mechanisms of radiation, using carefully engineered nanostructures. This innovative and unconventional control system is to be achieved by an unprecedented combination of theory and experiment. On the theoretical side, I plan to develop a Maxwell-Schrödinger self-consistent numerical toolbox, to fully understand the interaction of electron wave packets with light and nanostructures beyond the routinely used adiabatic approximations, but also to utilize our expertise in theoretical modelling to propose novel methodologies for coherent control and shaping of the electron beams. On the experimental side, I intend to develop a novel spectral interferometry technique with the ability to retrieve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic  model of epilepsy – tuberous sclerosis complex' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Despite a great progress in the management of epilepsy, still one third of patients is refractory to available medications. The incidence of epilepsy is highest in infancy and 50% of children experience epilepsy-related comorbidities, such as developmental delay and autism. The development of epilepsy (epileptogenesis), extensively studied in animals, is barely studied in humans, as patients usually present AFTER the seizure onset.EPISTOP is the first prospective study of epileptogenesis in humans, beginning BEFORE seizures and continuing through age 2+ years, permitting detailed analysis of the onset, drug-resistance, and comorbidities of epilepsy. To maximize information derived from the study we have chosen homogenous group of patients with prenatal or early infantile diagnosis of Tuberous Sclerosis Complex (TSC). A clinical randomized study of pre-seizure treatment in TSC infants is a part of the project.The aim of EPISTOP is to examine the risk factors and biomarkers of epilepsy and to identify possible new therapeutic targets to block or otherwise modify epileptogenesis in humans. Biomarker analysis will be performed by a multidisciplinary, systematic approach in three clinical settings:1/ prospective study of epilepsy development in infants with TSC, including analysis of clinical, neuroimaging, and molecular, blood-derived biomarkers at predefined time points: before the onset of seizures, at the onset of epileptiform discharges on EEG, at seizure onset and at the age of 24 months2/ prospective study of blood-based biomarkers in infants with TSC treated with antiepileptic drugs prior to seizure onset in comparison to children treated only after clinical seizures appearance.3/ analysis of biomarkers of epileptogenesis and drug-resistant epilepsy in brain specimen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Development of an energy efficient bulk sterilisation technique for the production of mycelium (BULK SUBSTRATES)'.

assistant: **Objectives**

Abstract Europe experiences a rapidly growing demand for food-related mycelium products, such as mushrooms, fermented food products, mycelium for biocontrol and inoculum for composting. Mushrooms have the largest share in this sector, and particularly the  specialty" mushrooms rapidly gain importance.The EU production of the latter was 44 Mtons in 2002, worth 160 MEUR. Due to their novelty, figures are not yet available for other mycelium products. The raw materials used in such solid-state fermentations (SSF) are infection sensitive agricultural wastes. Unsafe hygienisation and inoculation lead to variable yield and quality.The regular supply of a standard isedmycelium product will lead to a stable market, and thus to a stable income for the producers. T his proposal is directed by 10 SME's from 6 EU- and 2 affiliated countries. They are mycelium producers with restricted research budgets and a clear common need: the development of a bulk production system for the safe, cost effective and energy friendly production of axenic mycelium.It will include sterilisation of raw materials, followed by aseptic cooling and inoculation, and portioning under strictly hygienic conditions. The proposal includes the co-ordination and 5 research WP's. Each WP highlights an aspect that is crucial in the process. Sterile handling has top priority. Furthermore, there will be a focus on energy saving and labour friendliness.In WP 2 all substrate components will be inventoried and checked for relevant properties. WP 3 will deliver an appropriate inoculating system, while in WP 4 we will choose a safe system to fill pre-sterilised bags with the cooled and inoculated substrate.WP 5 will result in a multifunctional prototype, provided with appendages for e.g. air removal, steam injection and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding gamma delta T cells in colon cancer metastasis' under Horizon 2020.

assistant: **Concept**

Cancer is the leading cause of death in the world. Immunotherapy is having a major impact in counteracting these cancer-related deaths, since the activity of anti-tumour immune cells can be enhanced to kill cancer. Unfortunately, immunotherapy does not work for every patient, so we must understand how other immune cells participate in cancer progression to design new immunotherapies that may benefit a greater number of patients. One particular type of immune cell, called gamma/delta T cells, was recently shown by my Host to promote breast cancer metastasis via IL-17, an important pro-tumour cytokine. However, the significance of gamma/delta T cells and IL-17 in other cancer metastasis settings remains unclear. In this proposal, I will address this point using a newly developed sophisticated colorectal cancer metastasis model. This novel mouse model shows 100 percent penetration of metastasis, of which 80 percent is to the liver, similar to human colorectal metastasis. Using this metastasis model, I will: 1. Clarify characteristics of gamma/delta T cells in colorectal cancer metastasis, 2. Assess if depletion of gamma/delta T cells by a neutralizing antibody as well as crossing the model with gamma/delta T cell-deficient mice would reduce the occurrence of metastasis, and 3. Examine the involvement of BTNL1, which is a specific activator for anti-tumorigenic IFN-producing gamma/delta T cells in the intestine. The role of BTNL1 in any cancer setting and the importance of IL-17-producing gamma/delta T cells in colon cancer metastasis is largely unexplored. Addressing our goal to understand the role of these gamma/delta T cells in colon cancer metastasis, I will newly acquire expertise and technical skills in both immunology and cancer biology as well as have experience in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel possibilities for manipulating subsets of lymphocytes in transplantation and autoimmunity' (1994-1998).

assistant: **Concept**

XENOTRANSPLANTATION-TOLERANCE. 1. Objectives. An organ transplantation outcomes have improved the demand for this treatment is steadily increasing. If we are to continue this progress, two crucial issues must be solved: how can the supply of donor organ be improved and how can we induce specific and long lasting tolerance to replace non specific suppression. Induction of specific tolerance in xenotransplantation can potentially solve these issues. The major axis of this project is to try to induce specific tolerance in xenotransplantation by exploiting the fact that B Lymphocytes can now be subdivided into subsets performing different functions. The major barrier to xenotransplantation is the presence of preformed antibodies, mostly of the IgM type, which recognise glycoproteins or glycolipids from the xenograft. These preformed antibodies in the rat-guinea-pig model seem to be synthesised by the B-l subset. Using treatments by monoclonal anti-mu or anti-delta antibodies, we can manipulate, eliminate or enhance B cell subsets. Therefore we shall attempt to delete the mature B cell subset. We shall then expose the reconstituting immune system to xenoantigens. Immature B Lymphocytes are specially sensitive to tolerance induction. The state of the immune system will then be checked by injecting xenoantigens mixed with adjuvant and xenografts will be performed. All these studies will need the measure of the life span and apoptotic mechanisms of the different B cell subsets. We shall also make use of the finding that thymic epithelium grafts in able to induce transplantation tolerance. We propose also to apply the concepts and the tools described above to analyze the autoimmune diabetes of NOD mice which are a model for human insulin dependent diabetes mellitus (IDDM). While
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Volcano dome growth, collapse and coupled processes'.

assistant: **Innovation**

The construction of volcanoes, i.e. the intrusive and eruptive growth, can be intermittently interrupted by destructive events. Dome building volcanoes, in specific, grow by magma extrusion and are partially destroyed again, posing a significant hazard in form of pyroclastic flows and other processes. The explosion at Merapi (Indonesia) in 2010, and at Colima volcano (Mexico) in 2013 are good examples of associated dramatic topographic changes. There is only limited understanding of the deformation style of the dome and the stress changes within and beneath, because sophisticated geodetic methods are hazardous to operate and are even destroyed during eruptions. In VolCapse, small scale displacements (<1 m/yr) at dome building volcanoes will be quantified by new generation satellite radar data. Larger scale displacements (>.1 m/yr) will be determined by time-lapse camera arrays that allow the visual recording of volcano summits from different viewing geometries, together with photogrammetric and image correlation approaches. This displacement data of the studied volcanoes shall allow to develop statistical and numerical models to investigate (i) how dome displacements affect the further magma extrusion position, (ii) how large morphology changes in the volcano summit affect dome growth by topographic loading or unloading, (iii) how dome growth is affected by extrinsic triggers such as tectonic quakes, and (iv) how simultaneous displacement processes such as cooling, extrusion and gravity driven deformation interfere.The P.I., with yearlong experience in modern geodetic methods, modelling and physical volcanology, herein describes the VolCapse project with the goal to enlighten our understanding of the coupled processes occurring during the different stages of volcano gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Port EnvironmentAl infoRmation colLector' (PEARL), addressing dissemination and exploitation.

assistant: **Impact**

Ports are highly affected by ocean conditions and pollution events near the Port. Moreover, European legislation is also requesting better information. A remote and continuous monitoring of a wider geographical area is a key aspect for improving the understanding port environment phenomena, as well as anticipating risk situations that will affect the port.There are a large number of systems in place to gather relevant geo-information data, mainly meteorological, water quality, oceanographic and pollution related. However, it is clear that the systems used presently are in-situ sensors and are mainly used to gather specific data within or near the port area. Improving information flow by increasing the number of in-situ sensors deployed is a costly investment strategy. Space data is seriously underused by Port Authorities due to different obstacles, although it space data is becoming more and more available appears that EO data is able to provide valuable information in areas near the coastline.At the same time, projects such as the FP6 IP MERSEA focus on the delivery of oceanographic products exploiting space data and model innovation. These data products are very relevant to Ports. PEARL will seek to address the above issues by developing a Port Environmental Management System enabling the optimal exploitation of space and in situ data products. Pearl aims at providing, for the first time, a platform focusing on Ports and their environmental problems for user friendly access of in situ and space data and models, and their efficient combination. Pearl aims at educating the user community on the information content available from space and in-situ instruments, as well as on current limitations.