RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'hERG related risk assessment of botanicals' (HERGSCREEN).

assistant: **Concept**

The main goal of this project is the establishment of a network between European, South American, North American and South African educational and research entities. This attempt will be based on an innovative scientific project aiming towards the identification of hERG (human Ether-à-go-go Related Gene) channel blockers in commonly consumed botanicals and supplements. Blocking these ion channels may result in ventricular tachyarrhythmia and an increased incidence of sudden death. Thus, the hERG channel is considered as an important antitarget. Several drugs have been removed from the market for this reason, and compounds have been blocked from proceeding further into phases of clinical development. As botanicals (comprising dietary supplements, spices, herbal medicinal products) continue to increase in popularity there is an urgent need for studies aimed to critically assess the potential cardiotoxic risks of these products.State-of-the-art methodologies and techniques will be incorporated for target-oriented identification and isolation of hERG channel blocking constituents. PK and PD studies will be performed and LC-MS based methods will be developed and applied towards the measurement of bioactive components in biofluids samples. Comparison of biofluids derived from administration of single chemical entities and corresponding botanicals will be achieved using MS- and NMR-based metabolomics. The obtained results will help to elaborate and evaluate hERG related safety aspects aiming towards the risk assessment of frequently consumed botanicals.Within this frame numerous short term and extended secondments of scientific staff will be accomplished, while the organization of several workshops will assure the proper dissemination of the produced knowledge throughout all t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural exploration of GD3 ganglioside-COVID spike Protein Interaction and siglec-7 Role in inhibition of virAL infection' (SPIRAL).

assistant: **Innovation**

The present project focuses on deeply comprehending the molecular basis of glycan recognition events by key protein receptors at atomic level, directly connected to processes related to immune response, infection and cancer. We will elucidate using Nuclear Magnetic Resonance (NMR) and other biophysical techniques the binding preferences of the recognition event between GD3 ganglioside and the Spike proteins of OC43 and HKU1 human coronavirus (HCoV) variants, along with Siglec-7. The role of Siglec-7 in inhibiting the HCoV viral infection will also be addressed. This research will make a significant and direct contribution by unveiling the roles of glycosylation patterns and cell receptors in HCoV infection mechanisms.Dr. Bermejo, the applicant, defended her PhD Thesis almost five years ago and was awarded a MSCA-IF fellowship for the past three years. During this time she has grown into an excellent researcher in chemical biology, possessing practical experience in organic and peptide synthesis, drug design, lipid nanoparticles formulation, cell culture and binding assays. Through the awarding of this fellowship she will join the lab of Prof. Jesus Jimnez-Barbero the Scientific Director of the host institution (CIC bioGUNE) and Leader of the Chemical Glycobiology lab. He is one of the best-known scientists in glycan research at the national and international levels.Thanks to this action, Dr. Bermejo will consolidate her multidisciplinary scientific proficiency, acquiring new competences in enzymatic synthesis and protein expression and purification and trend setting NMR concepts and techniques. She will contribute to the host with her expertise in glycan and glycoconjugates synthesis, and will bring her expertise in liposomal formulation, setting up a microfluidics devi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Linked Knowledge in Manufacturing, Engineering and Design for Next-Generation Production', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

What is clearly missing in the current ICT landscape for manufacturing is an integrated, holistic view on data across the full product lifecycle. Especially the design and engineering of products and manufacturing processes is decoupled from the actual process execution. As experiences of the past show, a tight integration of all tools used throughout a product lifetime is not feasible.LinkkME addresses these shortcomings by providing an integrated, holistic view on data, persons and processes across the  product lifecycle as a vital resource for the outstanding competitive design of novel products and manufacturing processes. To achieve this goal the project will develop the Linked Engineering and mAnufacturing Platform (LEAP) as an integrated information system for manufacturing design. LEAP federates all product lifecycle information relevant to drive engineering and manufacturing processes, independent of its format, location, originator, and time of creation. Besides the unified access to the integrated information, LEAP will provide specific knowledge exploitation solutions like sentiment analysis and design decision support systems to analyse the integrated information.Within LinkkME we aim for a user-centric lifecycle information management. LEAP will provide a context-driven access to federated information and knowledge and foster cross-discipline collaborations between users by novel approaches for collaborative engineering.Finally, LinkkME will provide tight feedback connections to existing engineering tools (e.g., CAx Systems) in order to push back formalised knowledge to enable the automated design of elementary product components.All concepts and components developed within the LinkkME project will be evaluated using three application prototypes deployed a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Laser Resonance Chromatography of Superheavy Metals' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project aims at developing a novel method of optical spectroscopy to study the wholly unexplored atomic structure of the superheavy transition metals, starting with element 103, lawrencium (Lr). My team will experimentally identify optical spectral lines that will serve as fingerprints in the search for superheavy elements in the universe. The spectral lines are strongly influenced by relativistic and quantum electrodynamic effects and thus will constitute powerful benchmarks for atomic modeling incorporated within this project. Furthermore, since the nuclear charge distribution influences the atomic structure, our experimental data will advance our understanding of the effects of nuclear shells and deformations on the stability of radionuclides at the top of the Segré chart.While I recently opened up the atomic structure of element 102, nobelium, the new challenges faced are the refractory nature of the elements, which lay ahead, coupled with shorter half-lives and decreasing production yields. I propose to overcome these by developing an ultra-sensitive and fast Laser Resonance Chromatography (LRC) to set the new standard in optical spectroscopy. The LRC method combines the element selectivity and spectral precision of laser spectroscopy with cutting-edge technology of ion-mobility mass spectrometry. Based on high-accuracy atomic calculations, my team will optically probe the 1S0-3P1 ground-state transition in singly-charged 255Lr ions and record the distinct arrival times of the ions after passing a drift tube to identify the laser resonance signal. We will perform the experiments at leading in-flight facilities such as the GSI velocity filter SHIP and the new GANIL separator S3. Crucially, the LRC method will be insensitive to physicochemical properties and tol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Complex dynamic interactions of nonlinear, multistage and localization phenomena in turbine engines: development and validation of efficient and accurate modeling techniques.""' in the context of a Seventh Framework call.

assistant: **Objectives**

Current and next-generation turbine engines will increasingly depend on onboard health monitoring and prognosis systems to help ensure the reliability, safety, and readiness of air vehicles.To effectively interpret the measurement data required for monitoring and prognosis of turbine engines, efficient reduced models that show to capture the essential complex dynamic interactions of nonlinear, multistage, and localization phenomena must be employed. In the research project, advanced structural dynamic models and experimental validations will be developed for turbine engine rotors.The main goals of the proposed research are:•To model and predict the nonlinear vibration response of a rotor with cracked blades or blades damaged by a foreign object, including accounting for random mistuning and multistage coupling.•To provide a fundamental physical understanding of localization phenomena in rotors due to individual and combined effects of mistuning and foreign object damage and/or cracks.•To identify localization phenomena and nonlinear vibration characteristics strongly associated with cracks to exploit them for structural health monitoring and damage detection.Although structural health monitoring tools will not be developed directly in this research, the work will help describe and understand the fundamental nonlinear structural dynamics so that the proposed modeling technologies can be used in health monitoring and prognosis applications.During the project, the fellow will acquire new competencies and skills in the field of non-linear modeling of cracked bladed disks and multi-stage modeling techniques of bladed disks, strengthening his academic profile in the field of modeling techniques and structural health monitoring of turbine engine.The fellowship will impact on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Properties of gamma homology of commutative rings and e infinity ring spectra' (1994-1998).

assistant: **Innovation**

The aim of the proposal is to explore several theoretical problems relating to the title, including: * The relationship of gamma homology to other theories such as topological Hochschild and cyclic homology and algebraic K-theory. * Calculations of gamma homology groups, for example for polynomial algebras. * The development of a cyclic version of gamma homology, including study of its properties, its relationship to ordinary gamma homology and calculations of cyclic gamma homology groups. * The properties of discrete commutative algebras captured by gamma homology. * Decompositions of the Eulerian representations of the symmetric group into irreducibles. I also aim to * Broaden my understanding of topological Hochschild and cyclic homology, MacLane homology and K-theory. * Develop contacts with the many active researchers in France working in this area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Pre-clinical improvement of combined immunotherapy and chemotherapy for a new variant Creutzfeldt-Jakob disease'.

assistant: **Innovation**

Tees are invariably fatal and are still incurable. Recent reports have shown that anti-Prepuce antibodies reduce Preps in infected-infected cells. Based on this data, we have infused anti-Prep antibody Fib fragments intracerebroventricularly in FVB mice with experimental scrape and demonstrated a delay in the clinical signs. The aims of this project are:(i) to confirm these encouraging results in mice with experimental scrape or BSE,(ii) to optimise immunotherapy protocols (intracerebroventricular and intraperitoneal),(iii) to combine this immunotherapy with emerging chemotherapeutic agents including the chlorpromazine/aquamarine regimen, and(iv) to rationally improve the anti-Prep antibodies, by creating chimerical constructs with targeted transcytosis through the blood/brain endothelium. These studies will culminate in phase I clinical trials in human niche and CJD patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Achieving sustainability in transport and land use' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This Accompanying Measure is designed to achieve the diffusion, exploitation, transfer and take-up of research results from a Cluster of five projects funded under Task 4.4.1 of the City of Tomorrow Key Action. To this end it aims to achieve synergy between the five projects; to encourage collaboration with related national and regional projects; to identify the best ways of achieving dissemination and take up of research; and to enable this through an interactive website and a final dissemination workshop. The actions involved will include a technical workshop, a survey of related projects, two dissemination workshops and the website, as well as closer collaboration between the Task 4.4.1 projects. The end result should be an enhanced ability among cities in the European Union and the Accession Countries to identify and implement sustainable land use and transport strategies, and greater coordination among related research projects throughout the European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations'.

assistant: **Innovation**

Recently, the European Medicines Agency (EMA) and the U.S. Food & Drug Administration (FDA) recommended suspension and warning labels for Gadolinium (Gd)-bearing CAs (GBCA) used in magnetic resonance imaging (MRI). This decision, although made in the absence of any clinical evidence, relates to potential major health concerns resulting from long-term accumulation of Gd containing species in patients’ bodies. This sends a clear message that we need to carefully consider the necessity of each contrast injection in individuals undergoing an MRI scan. However, for a number of diagnostic procedures, such as tumour characterisation, the use of a CA is often essential. The accumulation of Gd in different organs (including the brain) and GBCA-related diseases requires the scientific community to seek radically new alternatives. The AlternativesToGd vision is to identify and validate radically new compounds and technologies as alternatives to GBCAs. The new compounds and technologies developed in this proposal will be tested in animal models of disease and the most promising ones selected for further clinical development. The expected outcomes should radically impact the field, likely leading to a paradigm shift in MR-based diagnosis and thus being highly beneficial to society. The AlternativesToGd consortium will develop a new class of MRI CAs that will be metal-free, safe, and completely eliminated from the human body after the MRI exam. The agents will consist of small endogenous molecules, in which nuclear spins will be hyperpolarised to ensure high sensitivity to MR detection, even at very low doses. A major challenge and risk arises from the rapid decay of the hyperpolarised (HP) state. As enabling technologies, AlternativesToGd focuses on three leading and innovative hype
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular and supramolecular aspects of hairy rod polymers containing side ionic groups' under Fourth Framework.

assistant: **Concept**

Research objectives and contents The main purpose of my research work is the synthesis and the characterization of poly-p-pllenyletle derivatives and of cellulose derivatives, bearing ionic side groups, like sulfonic, carboxylic or phosplloric acids . These hairy rod type polyelectrolytes, show interesting association phenomena like the formation ol cylindrical micelles They give rise to Iyotropic liquid crystals at very small concentrations in aqueous media. Interesting points are what controls their aggregation to Ic-phases? Do they form monolayers and multilayers by the Longmuir-Blodgett technique as well as hairy rod polymers without ionic side groups? I will concentrate my research work on the following points - correlation between molecular weight and phase behaviour, - influence of charge density on the formation of the Iyotropic phase (the type of Iyotropic phase has to be investigated); - study of the phase diagram and its dependence on salt concentration - crosslinking reactions to stabilize chemically the supermolecules, which form spontaneously by aggregation. Training content (objectives, benefit and expected impact) This period of training will allow me to increase my expertise in the field of LC polymelrs, to learn the use of methods such as electron microscopy, surface force microscopy, Langmuir-Blodgett technique and to apply other methods in the synthesis, like tile Suzuki-coupling method.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SCAlable & ReconfigurabLe Electronics plaTforms and Tools' to be submitted under Seventh Framework.

assistant: **Abstract**

The first generation of Integrated Modular Avionics (IMA1G) has been researched via European funded research projects; PAMELA, NEVADA and VICTORIA. This technology supported a revolutionary step away from federated architectures and their classical bespoke electronics to a modular architecture with common resources. IMA1G was introduced to the market on the A380, A400M and B787 aircraft. IMA1G replaces multiple, dissimilar equipment with fewer common processing and I/O modules, sharing high speed communication links. IMA1G has demonstrated possible implementation and derived benefits when applied to a limited number of aircraft functions for example; the number of processing units in the new A380 is half that of previous generations and a reduction in airline operating costs of between 15 and 20% is expected through significant weight reduction and maintenance savings. However IMA1G is only a first step in the evolution toward a full IMA concept The concept of the SCARLETT project is based on a shared analysis made by the European Aerospace Community, which has identified the need to undertake research leading to a new generation of IMA, defining a scalable, adaptable, reconfigurable fault-tolerant driven and secure avionics platform, namely the DME: Distributed Modular Electronics.  By implementing the innovations in the DME concept, SCARLETT will progress the state-of-the-art beyond the current IMA1G in the following areas: - Scalability, portability and adaptability - Fault tolerance and reconfiguration capabilities - Minimize the number of types of standardised electronic modules - Support a full range of avionics function In addition innovations in the area of advanced processes, methods and tools to improve IMA implementation efficiency are proposed. SCARLETT will