RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High-Fidelity Photonic Quantum Gates' (HIFIG).

assistant: **Innovation**

An efficient nonlinear quantum gate between two single-photons is highly desirable, as it will enable processing quantum information stored in optical photons. This capability is essential for building next generation of quantum networks, and optical quantum computing. However, such a device is constrained by lack of interaction between optical photons in natural environments. Interestingly, cavity quantum electrodynamics provides several paths towards achieving nonlinear interaction between photons. This action aims at realizing a high fidelity and efficient nonlinear gate between two single-photons using a compact solid-state design. Our approach is based on using the spin-state of a hole in an InAs/GaAs quantum dot to mediate the interaction between the photons. It has recently been demonstrated that the quantum coherence of the hole state can be on the order of several hundreds of nanoseconds. Also, the hole-states have been shown to have very coherent optical transitions which makes them an ideal candidate to realize spin-photon interfaces. In order to boost the interaction between the photons and the quantum dot, a novel microcavity structure will be used. The microcavity structure has recently been developed in the host group and shows spectacular features such as a Q-factor of 1 million, and a cooperativity of 100, making the combination of the hole-state and the microcavity structure an ideal platform to realize photonic gates. The results of this action will be highly instrumental for building quantum repeaters, and may open new directions for quantum computers based on optical photons. For instance, such a nonlinear gate may be combined with a linear network of coupled waveguides to enhance the simulation capabilities of the linear network. Finally, this acti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid (CSF) and brain areas that control food intake. Little is known about their physiological roles. Recent studies indicate that tanycytes sense the extracellular glucose, release the intercellular messenger adenosine triphosphate (ATP) and the energy metabolite lactate, both of which can potentially modulate neuronal activity. Tanycytes also transport the blood-borne anorexigenic peptide leptin from the blood to the CSF and brain parenchyma. Understanding how this glia may be able to interact with neurons from the arcuate nucleus of the hypothalamus (ARH) that control food intake is critical to identify new cellular targets for the development of therapeutic strategies for treating metabolic disorders. Therefore, the series of experiments presented in the proposal are designed to determine how tanycytes may influence electrical activity of ARH neurons. More specifically, the project is based on answering the following questions: i) Does purinergic signaling in tanycytes modulate activity of ARH neurons? ii) Do tanycytes interact with ARH neurons through a metabolic network? iii) How do tanycytes redistribute captured leptin towards ARH neurons? Towards this end, I will use electrophysiological techniques in acute mouse brain slices and newly-developed genetic tools that allow selective manipulations of tanycyte signaling. Additionally, I propose to investigate how changes in metabolic status (e.g. obesity) may influence tanycyte-ARH neuron communication, providing new insights into functional mechanisms contributing to metabolic disorders. The TANYFEEDNEURONS project will provide direct evidence for tanycyte-neuron communication in the context of energy homeostas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Oxidative stress and platelet hyperactivity: the role of NADPH oxidases in haemostasis regulation in health and diabetes.'.

assistant: **Concept**

Platelets are circulating blood cells that help to arrest of bleeding (i.e. haemostasis) and promote the repair of blood vessels following injury. In type 2 diabetes mellitus (T2DM), platelets are hyperactive and their uncontrolled activation leads to the unwanted occlusion of blood vessels (i.e. thrombosis). Thrombosis is the main cause of mortality for T2DM patients, who display significantly higher risk of cardiovascular disease than the rest of the population. Currently, 70% of T2DM patients succumb to cardiovascular diseases.I have been working on pro-oxidant enzymes called NADPH oxidases (NOXs), which are responsible for oxidative stress and activation of platelets. I have shown that the enzymatic activity of NOXs generates oxidant molecules (i.e. free radicals), which in turn are responsible for platelet activation. In preparation to this application, I have generated data showing that platelets from T2DM patients contain higher levels of the NOX1 isoform. This enzyme is responsible for oxidative stress and hyperactivity of platelets from T2DM platelets compared to healthy controls. In this project, I aim to understand the molecular mechanisms underlying platelet regulation by NOXs and the contribution of NOX1 to platelet hyperactivity in T2DM. I will use human blood from T2DM patients and murine models of T2DM. In addition to clarifying the role of NOX1 in the vascular complications of T2DM, I will test whether NOX1 inhibitors synthesised in my laboratory can protect the health of the vascular system in this disease.Taken together, this project will markedly advance our understanding of how platelets are regulated and will generate novel information on the link between cardiovascular risk and T2DM, which may result in a substantial improvement of the clinical ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Type 1 Diabetes Simulator with Adjunctive therapies - GLP1'.

assistant: **Objectives**

People with type 1 diabetes (T1D) live with the burden of self-managing their glucose levels. Although automatic insulin delivery (AID) systems have alleviated this load, patients still need to count carbohydrates and administer insulin boluses at mealtimes, making the systems prone to human errors, which could have severe health consequences. Adjunctive therapies such as GLP-1 receptor agonists aim to mitigate these risks by reducing the impact of meals on the glucose rate of appearance in blood. These drugs are prescribed for type 2 diabetes, but they are currently being considered for their use in T1D. Simulators are one of the essential tools for developing AID systems and the foundation for digital twins, allowing testing and validating control algorithms while avoiding any risks for the patients. However, no T1D simulator includes descriptions of GLP-1 effects. The T1SIA project will develop a T1D simulator that includes a mathematical model of GLP-1 receptor agonists’ dynamics. This 2-year project will rely on the experience of the University of Bern and the Polytechnic University of Valencia. The first year at Bern will focus on developing a GLP-1 mathematical model, supervised by an expert in AID systems and a clinician expert in adjunctive therapies. In the second year at Valencia, the model will be integrated into a T1D simulator alongside a cohort of virtual patients under the supervision of an expert in diabetes technology. T1SIA will allow exploring the contributions of these novel therapy drugs for research and product-development purposes in the AID and pharmaceutical industry.  This project will push the candidate’s professional development, both for academic and industry positions, improving her knowledge of mathematical modeling, human physiology, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'An integrated POC solution for non-invasive diagnosis and therapy monitoring of Heart Failure patients'.

assistant: **Innovation**

The aim of the KardiaTool project is to translate a laboratory proven concept of a saliva biosensor to the clinical practice for addressing the priority needs in personalized HF diagnostics and therapy monitoring at the point of care. The KardiaTool platform includes: (i) An easy to use portable POC device (KardiaPOC) with a disposable Lab-on-a-Chip (LOC), for the non-invasive, rapid and accurate qualitative and quantitative assessment of HF biomarkers, from saliva samples. KardiaPOC device will integrate a variety of sensors, actuators, Microelectromechanical systems (MEMS), micro-electronics, bio-chemicals and functionalized magnetic nanoparticles (MNPs), onto a disposable, low cost LOC. (ii) A decision support software (KardiaSoft) based on predictive modelling techniques, that analyzes the POC data and other patient’s data, directly added by the healthcare professionals, and delivers information related to HF diagnosis and therapy monitoring. The innovation lays in the incorporation of four novel saliva biomarkers that have been proven in a laboratory setting and bring a new promising concept for addressing the priority needs of the clinical arena. KardiaPOC will provide the capability of simultaneously extracting key information from the saliva biomarkers: (i) NT-proBNP, (ii) TNF-a, (iii) Interleukin- 10, (iv) Cortisol. It is expected that identifying a comparable source to blood, for biomarker information, such as saliva, that is cost effective, less invasive, more convenient and acceptable for both patients and healthcare professionals would be beneficial for the healthcare community. The challenge of KardiaTool is: (i) to translate a laboratory proven concept of a saliva biosensor into an MNBS platform, for HF diagnostics and therapy monitoring, at the point of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TELEMATICS APPLICATIONS FOR NURSES', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

TELENURSE plans to promote an International Classification for Nursing Practice (ICNP) and a clinical nursing minimum data set (NMDS) in electronic patient care records to counter the lack of uniform comparative descriptive data on hospital nursing and its cost-effectiveness. Formally requested by the International Council of Nurses, the ICNP (and NMDS) will offer a framework for suitably structured nursing information systems and care records which will be used to validate the applicability of ICNP to European health establishments. The project will also demonstrate the role of NMDS in comparative summaries of nursing activity.Maintenance care and palliative care are major challenges to the European society. Care for the elderly, disabled and chronically ill relies mainly on nurses who account for close to 50% of salaries in hospital charges. But no systematized standardized data are available to describe and compare nursing care activity, quality and cost effectiveness in hospitals. Telenurse will as an accompanying measure of the Telematics Application Programme in the Healthcare sector start to fill-up this gap by promoting the use of the emerging International Classification for Nursing Practice (ICNP) and an associated clinical nursing minimum data set (NMDS) in electronic patient care records. Most of the group being active in this field in Europe are partners of the consortium. This will allow capitalizing on their experience by elaborating and initiating a strategy promoting the use of common nomenclature, minimum data set and data structure for nursing practice in Europe. ICNP (a mandate of the International Council of Nurses to the consortium coordinator) will serve as a base for structuring information. Available nursing information systems and nursing care
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Free-Space Optical Systems for Next Generation Communication Networks' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Free-space optical (FSO) communication is a license-free access technology with high-bandwidth capacity. It is a powerful alternative and/or complementary solution to commonly deployed fiber optic and wireless radio-frequency links. FSO is appealing for a number of applications including metropolitan area network extensions, enterprise/campus network connectivity, fiber back-up, back-haul for wireless cellular networks, disaster recovery, and quantum key distribution among others. Despite the major advantages of FSO technology and variety of its application areas, its widespread use has been hampered by its rather disappointing performance for long-range links. The major performance limiting factor for FSO links with ranges longer than one kilometer is the atmospheric turbulence-induced fading. Building upon the concept of cooperative diversity, the proposed research will devise efficient physical layer solutions tailored for the inherent characteristics of the FSO channel that remedy the shortcomings of existing systems. The proposed systems and techniques will provide a novel research framework on the design and analysis of relay-assisted (cooperative) FSO transmission. The results of this proposed research will be instrumental in the building of long-range, highly reliable, and ultra-fast FSO systems to meet the demanding requirements of next generation communication networks. This proposal is in fact a natural continuation of the applicant Dr. Uysal’s internationally renowned research program on FSO communication which he has carried out at the University of Waterloo in Canada. The Marie Curie International Reintegration Grant, if funded, will help Dr. Uysal transfer this internationally visible research program to Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Conflicting demands of land use, soil biodiversity and the sustainable delivery of ecosystem goods and services in Europe' in the context of a Seventh Framework call.

assistant: **Objectives**

European soil biodiversity is pivotal for delivering food, fiber and biofuels and carbon storage. However, the demand is greater than the amount of soil available, as production of biofuels competes with areas for food production and nature. Moreover, intensified land use reduces soil biodiversity and the resulting ecosystem services. SOILSERVICE will value soil biodiversity through the impact on ecosystem services and propose how these values can be granted through payments.   SOILSERVICE will combine interdisciplinary empirical studies and soil biodiversity surveys to construct soil food web models and determine effects of changing soil biodiversity on stability and resilience of carbon, nitrogen and phosphorus cycling, as well as assess consequences for outbreaks of pests or invasive species. SOILSERVICE will link ecological and economic models to develop a system for valuing soil biodiversity in relation to ecosystem services.   Objectives: • Develop methods to value soil ecosystem services during different pressure of land use and changes in soil biodiversity. • Field and modelling studies will determine to what spatial and temporal scales soil biodiversity and soil ecosystem services are vulnerable to disturbance. • Detecting processes that indicate when ecosystems are approaching the limits of their natural functioning or productive capacity.  • Establishing methods to determine and predict sustainability of ecosystem services at different types of land use • Building scenarios to identify economical and social drivers of how land use such as biofuel production and land abandonment can influence soil biodiversity and ecosystem services over European scale. • Interacting with EU policies and strategies with results on which services are at threat and mitigating ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cell therapy for patients with chronic heart failure with proprietary  cardiac-derived cells (CardAP cells)  –  “From the Heart to the Heart”' (CardAPcells).

assistant: **Concept**

Chronic heart failure is a life-threatening disease usually without cure and a leading cause of morbidity and mortality. In Germany 45 000 patients (projected to EU: about 140 000) die every year from progressive chronic cardiac insufficiency. There is no curative therapeutic solution, except very rare donor hearts and artificial hearts as bridge devices.Researchers at the Charité - University Medicine, have identified unique cardiac-specific stromal cells (CardAP cells) with strong efficacy in cardiac stress models. CardAP cells are specialized heart-derived cells with key advantages in safety and efficacy.CardAP cells fulfil all criteria for cardiac cell therapy and cell product manufacturing has been transferred to GMP facilities. CellServe, a Charité spin off, will develop the CardAP cells for therapy of patients suffering from severe life-threatening cardiomyopathy. CellServe has acquired an exclusive license of this technology and will perform a clinical phase I/II study for patients with chronic cardiomyopathy. The technology of CellServe is completely distinct from all competitors, using specialized stromal heart cells and not stem cells. CellServe has an experienced management in cell-based therapies area to develop and market ATMP products. It will apply for a so-called hospital exemption regulation, a limited preliminary approval, for early market introduction directly after the clinical study.Commercial potential: Worldwide 22 Mio people suffer from chronic cardiac insufficiency.  In Phase 1 a business plan for the CardAP cell product will be generated including financial calculations and the preparations for the clinical study will be finalised. Achievements Phase 2: • Phase I/II clinical trial • Approval for Hospital Exemption for ATMPs • Preparation of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular cross-talk of light perception and development for plant adaptation to the environment' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Plants perceive the presence of dense vegetation as a change in light quality, i.e., a reduced red to far-red (R:FR) ratio. The responses to shade are generally referred to as the shade avoidance syndrome (SAS), and involve various changes in growth and physiology intended to overgrow or survive neighboring plants. Molecularly, phytochrome photoreceptors rapidly modulate plant development modulating the expression of several dozens of genes likely instrumental for implementing SAS responses that are likely forming a transcriptional web in Arabidopsis. A few of these genes encode partially redundant positive and negative regulators. The high amount of putative regulators (e.g. PAR1 and HFR1) suggests that to understand the SAS it is crucial (i) to establish the functionality of these regulators and (ii) to understand how they are organized in this web of transcriptional interactions. Hence, a major objective of this project is to define the architecture of the SAS transcriptional network in which PAR1 and HFR1 participate and to find out whether they are working in the same or different regulatory modules. In addition, the molecular basis of the cross-talk between shade perception and endogenous age-dependent transcriptional networks, such as those controlling hormone signaling and/or other developmental responses has to be clarified. Specific objectives are: Identification of 1) PAR1 and 2) HFR1 interacting nuclear transcription factors and their respective networks, 3) direct target genes of PAR1 and HFR1 proteins, and 4) age- related differences in molecular control of the SAS. With respect to the IEF call, this project will provide advanced research training to the applicant C. Then, a plant ecophysiologist, willing to extend her previous expertise (plant ecophysiolo