RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Turning off the furnace: the intracellular brake systems for brown fat thermogenesis' (BATOFF) under Horizon Europe.

assistant: **Objectives**

Free-ranging animals are continuously exposed to fluctuating ambient temperature, therefore rapid fine-tuning of thermogenesis to maintain core temperature homeostasis is critical for survival. Brown adipose tissue (BAT) evolves as a thermogenic organ, the rapid switching on and off is essential for thermal regulation. Of note, thermogenesis inevitably comes at high energetic cost and BAT ultimately is an energy-wasting organ. A constrained strategy that minimizes BAT activity unless obligate will have been favored during natural selection to safeguard metabolic thriftiness. However, this tenet and the molecular basis that constrain BAT activity remain unappreciated, unexplored and unexploited. Filling this fundamental knowledge gap will unlock endogenous constraints and allow efficiently and fully harness the energy-consuming potential of BAT for therapeutic interventions. To this end, I identify that a phase separation-aided molecular event, a lipolysis-stimulated feedforward regulatory circuit with negative feedback loop, and a purinergic nucleotides flux-based inhibitory mechanism, are synergistically involved in rapidly terminating heat production. BATOFF aims to study: 1) how these previously unappreciated mechanisms allow mammals to effectively orchestrate dynamics of BAT activity; 2) whether these constraining brake systems are malfunction under pathophysiological conditions; and 3) the translational potential of targeting these brakes. I will address these questions using state-of-the-art gain and loss-of-function in vitro and in vivo studies, newly-generated mouse models, high-resolution cellular respirometry, live cell imaging, and cutting-edge 'omics'. Results of BATOFF will not only provide a transformative molecular understanding of the cellular processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

TRANSLINK is a project devoted to assessing the mid-to long-term risk factors and improve the outcome of animal (bovine/porcine)-derived Bioprosthetic Heart Valve (BHV) implants. 300,000 patients/year benefit from BHV, a major healthcare problem (second most frequent cardiac surgery). BHV clinical outcome suffers from late dysfunctions restricting their application to older recipients. Based on a retrospective (already computerised) and prospective cohort of approximately 3,000 BHV recipients and control patients from 3 large EU cardiac surgery groups, TRANSLINK aims primarily to establish the possible role of recipients' immune response (IR) against BHV as a major cause to mid- to-long term clinical dysfunction. Precise molecular analysis of preimplantation BVH sugar moieties will be performed.  Possible indirect side-effects on BHV endocarditis and host vessels inflammation are secondary end points. Serial and trans-sectional blood samples will be dispatched to a battery of highly specialised partner groups for testing anti-Gal, -Neu5Gc and -hyaluronic acid antibodies (Ig) using both validated and newly designed screening tools, glycan array patterns, and macrophages/NK responses. Data will be crossed with clinical outcome scores. Project design aims at delivering comprehensive recommendations in the time-frame of the grant. Fundamental basic science progress in the field of carbohydrate antigens is also expected. Furthermore, prevention (BHV from engineered animal source lacking major antigens) and treatment (bioabsorbants of deleterious Ig) oriented remedies as well as prospective biomarkers of longterm BHV deterioration will be set up by three first-class SMEs. TRANSLINK may strongly impact the treatment of heart valve diseases by improving morbid-mortality in pati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A review of the status of research and training in architectures for nanoelectronic and nanophotonic systems in the European Research Area.' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Much world-wide effort is being devoted to research into nanoelectronic and nanophotonics devices, but less effort is being applied to examining system architectures, which might use these devices to best advantage. Such research is needed, so that present-day increases in computing power can be extended into the future. To achieve such increases will be a major technological challenge, and proactive research and planning is needed now. Some unanswered technical questions are: Can devices be assembled into ultra-high density circuits? Are any of these devices fundamentally unsuitable? Will factors such as size variations affect performance? Can manufacturing faults and transient errors be overcome using fault tolerance? Will the circuits have better performance than CMOS-type circuits? Will nanoscale circuits be cheaper than CMOS? Besides these technical questions, two other questions must also be asked: What systems research is being carried out now, and what gaps are there? - and are there enough trained people in Europe who are capable of solving these problems? Some but not all of these questions are being looked at under existing EC initiatives.We therefore propose a survey which, starting from the existing EC Nanoelectronics Roadmap, would report on existing European expertise in the following areas:1. existing and proposed nanoelectronic/photonic devices;2. small circuits: theory and practice;3. ultralarge circuits: theory and practice;4. conventional architectural concepts;5. unconventional concepts;6. new concepts;7. known problems;8. 'system on a chip' and 3D systems;9. applications: performance requirements;10. availability and training of human resources.The report will suggest topics where further effort might be applied, ranging from basic theoretical rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'CHROMATIN-REPAIR-CODE: Hacking the chromatin code for DNA repair'.

assistant: **Concept**

Our cells receive tens of thousands of different DNA lesions per day. Failure to repair these lesions will lead to cell death, mutations and genome instability, which contribute to human diseases such as neurodegenerative disorders and cancer. Efficient recognition and repair of DNA damage, however, is complicated by the fact that genomic DNA is packaged, through histone and non-histone proteins, into a condensed structure called chromatin. The DNA repair machinery has to circumvent this barrier to gain access to the damaged DNA and repair the lesions. Our recent work suggests that chromatin-modifying enzymes (CME) help to overcome this barrier at sites of DNA damage. However, the identity of these CME, their mode of action and interconnections with DNA repair pathways remain largely enigmatic. The aim of this project is to systematically identify and characterize the CME that operate during DNA repair processes in both yeast and human cells. To reach this goal we will use a cross-disciplinary approach that combines novel and cutting-edge genomics approaches with bioinformatics, genetics, biochemistry and high-resolution microscopy. Epigenetics-IDentifier (Epi-ID) will be used as a tool to unveil novel CME, whereas RNAi-interference and genetic interaction mapping studies will pinpoint the CME that may potentially regulate repair of DNA damage. A series of functional assays will eventually characterize their role in distinct DNA repair pathways, focusing on those that counteract DNA strand breaks and replication stress. Together these studies will provide insight into how CME assist cells to repair DNA damage in chromatin and inform on the relevance of CME to maintain genome stability and counteract human diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New Mobility in Friuli Venezia Giulia' to be submitted under Horizon 2020.

assistant: **Abstract**

‘NOEMIX – New Mobility in Friuli Venezia Giulia’ supports the transition towards e-mobility in public fleets by building integrated technical, economic and legal expertise for the launch of concrete investments.NOEMIX combines public and private organizations with institutional competence (Regional Authority FVG is the leading public administration), technical/technological and economic/financial expertise and securing the involvement of private sector operators.NOEMIX implements a participated approach to involve the main public and private stakeholders, including mobility service providers, the lenders’ community, procurers and final users of the mobility service.The project aims to:-develop an innovative, standardized and easily replicable methodology based on the transition from a ‘fully public-owned fleet’ model to a ‘public-private mobility service partnership’ exploiting regional demand aggregation;-replace a significant share (around 30%) of vehicles owned by public institutions through a mix of rationalization in use and a mobility-as-a-service scheme based on long-term lease and car-sharing of e-vehicles;-trigger e-mobility and RES-plants investments for € 21,4m with a 1:23,7 leverage factor;-build technical economic, legal capacity within public authorities;-support the uptake of the methodology, tools and outcomes developed in NOEMIX by regional authorities in new areas and countries.The work-plan entails 4 main steps for the development of the scheme (participated context analysis, technical feasibility study, financial scheme and business plan, legal/administrative procedures to launch the tender), measures dedicated to dissemination and replication of the scheme (national/international Committee of Observers and replication laboratories). The above combin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Characterisation of lactic acid bacterial enzymes and their biotechnological potential in wines' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project is aimed at applying laccases enzymes from lactic acid bacteria (LAB) to eliminate undesirable substances in wines such as toxic compounds (biogenic amines-BA and ochratoxin A-OTA) and off-flavors (volatile phenols - VP) produced from yeasts, fungi and bacteria during the winemaking process.Wine has become a daily consuming-product and the EU is the world’s leading wine producer (60% of world production). To guarantee food quality and safety control for consumers, winemakers normally use physical and chemical methods to reduce toxins and off-flavours in wines, which will be replaced with LAB laccases to avoid environmental and health problems.The main objective of this project is to explore the structure, practical applications, and the activity of LAB laccases on BA, OTA and VP in wines and determine and quantify their degradation products in order to improve the wine quality. Specific objectives are to look for new LAB enzymes to eliminate aromatic defects and toxins in wine and determine their degrading products on BA, OTA and VP, to explore their structure and new applications, to discover chaperons that improve laccases expression and to evaluate the enzymatic activity on wine quality. In order to accomplish these objectives, four stages of the project have been established, which include the genome mining and laccases expression and purification, their activity evaluation in wine and the search of the protein structure.To achieve all these goals, it is required a large combination of technical and transversal skills that will greatly improve the potential of the candidate to become a leader in wine bacteria biotechnology given his background as Biochemical Engineer and his previous experience as researcher in the line of biochemical processes modellin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Solid state lithium ion polymer batteries', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives In spite of many advantages (high energy- and power density, safety, low cost, and environmental acceptability) lithium polymer battery technology is unable to meet EUCAR performance targets for traction batteries. Overall advances needed in producing a 24 V, 25 Ah EV battery module with energy content of 0.5 kWh include: Energy density in solid state lithium ion polymer battery cells: 150 Wh/kg Power density in solid state lithium ion polymer battery cells: 150 W/kg An industrially feasible production process Validation of the lithium ion polymer electrolyte technology for EV applications Success in fulfilling EUCAR performance demands will be assessed in the final stage of the project. Technical Approach Critical aspects of the technology will be improved in efforts to meet EUCAR demands. These include: Stability of solid polymer electrolytes Electrode materials with improved specific energies Manufacturing processes Electrical management Monopolar battery module design Materials and processes will be developed for fabricating first laboratory cells, later entire monopolar batteries, and ultimately a complete 0.5 kWh EV battery module. Expected Achievements and Exploitation The project passes through a sequence of materials, component, cell and battery-module analyses, prior to evaluation according to EUCAR procedures. The following advances are expected: Optimal specification of a carbon-based anode material (specific capacity: 375 Ah/kg). Optimised specification of a lithiated oxide cathode material (specific capacity: 140 Ah/kg). The specification of a lithium polymer electrolyte compatible with the selected electrode materials (ionic conductivity: 10-3S/cm; stability windows vs Li/Li+: 0-4.5V). Cost-effective processes for lithium polymer battery electr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'O Social Groups, Where Art Thou? A cross-national and longitudinal analysis of the place of social groups at the core of the party-voter representative linkage'.

assistant: **Innovation**

The party-voter representative linkage is central to modern democracies. Because political parties, once in office, steer fiscal and social policies, the social groups they claim to represent in their group appeals matter for distributing tangible public goods and specially the equitable treatment of minority groups by the government. While many party politics studies are devoted to parties’ policy appeals and their role in political representation, group appeals have received little attention thus far, leaving a theoretical and empirical gap. Recent studies begin to address this oversight but these works are still few and limited in scope, using either longitudinal, single-country data, or cross-national, time-limited data. Combining insights from political, communication, and computational linguistics, GAPREP will build a new software library (SL) for the computational analysis of political texts (R package). The SL will then be used to analyse group appeals in more than 950 election manifestos in Belgium, Denmark, France, Germany, Netherlands, Norway, Sweden, and the UK between 1949-2022, building a new and publicly available dataset. Together with cross-national historical survey data on voters’ demographics and party preferences from the 1980s onwards (given available data), advanced statistical modelling will reveal how representative of social groups parties have been over the past 40 years. Pushing scholarship on the party-voter linkage still further, the project will also use a unique vignette survey experiment to study the underlying mechanism of this linkage by examining voters’ reactions to parties’ group appeals. Combining these efforts, findings will illuminate social groups' access to power, and social and political equality. Offering a new perspective on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Quantum Teleportation of Remote Solid-state Spins' (QTORSS).

assistant: **Innovation**

Quantum information processing is a key future technology. Algorithms based on quantum information have been proven to offer superior communication security and the ability to solve classes of computational problems that are not accessible to current classical information technology. Quantum entanglement and quantum measurements are two fundamental resources in quantum information. When combined, they enable one of the most dramatic applications of quantum mechanics: the teleportation of a quantum state between two remote systems.Solid-state systems promise a scalable implementation of quantum information technologies, but experiments aiming at long-range coupling of solid-state quantum registers are still in their infancy. Here we propose a set of ambitious experiments to demonstrate the long-range teleportation of solid-state quantum bits. We will entangle the electron spins of two remote Nitrogen-Vacancy (NV) centers in diamond by combining spin-photon entanglement and two-photon interference, and will subsequently demonstrate the teleportation of a nuclear spin state between two NV centers through quantum measurement and local qubit operations.This proposed first demonstration of teleportation with solid-state quantum bits will constitute a significant advancement in quantum information processing, and makes an important step towards the realization of quantum repeaters and quantum networks.The proposed experiments use advanced techniques from electron and nuclear magnetic resonance, single-molecule spectroscopy and quantum optics. This multidisciplinary research provides an excellent opportunity for the applicant to further strengthen and diversify his research expertise. Together with the extensive training in complementary skills provided by the host group, this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modeling organizations as networks of processors' to be submitted under Fourth Framework.

assistant: **Abstract**

Summary of the project: Andrea Prat - Research Proposal: Modeling Organizations as Networks of Processors Abstract  Information processing is an increasingly important activity in all organizations but until recently it had not found a systematic formalization. Radner (1993) and Bolton and Dewatripont (1994) proposed to study information processing by modeling the organization as a network of processors. Each agent is represented as a processor with limited computing capacity. Prat (1997) has extended the approach to include processors with heterogenous and endogenous capacity. This research applies such approach to characterize several properties of efficient network of processors. Particular attention will be given to: (1) the existence of diminishing returns to scale; (2) the optimal mode of coordination; (3) the tradeoff between size and delay; (4) the endogenous differences in abilities and competencies among the agents who work in the organization: and (5) the effects of the adoption of information technology (IT). The research aims at relating the results on efficient networks of processors with the practices of real organizations.