RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Decoding the path to cellular variation within pathogen populations'.

assistant: **Innovation**

Heterogeneity amongst isogenic cells is pervasive throughout biology. Recently developed single-cell omics approaches are beginning to systematically reveal the repertoire of functionally distinct cell subpopulations within metazoan tissues. Pathogens frequently encounter changing and often hostile environments. To adapt to these challenges unicellular pathogen populations also exhibit a large degree of cell-to-cell heterogeneity, which often affects the outcome of infections. Yet, despite the importance of this cell-to-cell variation, very little is known about the mechanisms that control the level of heterogeneity in pathogen populations or why some isogenic populations are more heterogeneous than others. The goal of switchDecoding is to unveil the path to cellular variation. To this end I will go beyond identifying and describing new subpopulations of cells and elucidate the molecular pathways that establish them and modulate the level of cellular heterogeneity. As a model I will study the mechanism responsible for creating heterogeneity in surface antigen expression in the unicellular parasite Trypanosoma brucei. Antigenic variation is a widely employed strategy by evolutionarily divergent pathogens to evade the host immune response. Using a multidisciplinary approach, I will develop and combine single-cell multi-omics, lineage tracing and CRISPR-Cas-based genome manipulation strategies to characterize the processes, pathways and molecules regulating antigen switching in T. brucei. A better understanding of the mechanisms affecting the level of heterogeneity within a pathogen population will enable us to better predict how pathogens adapt to environmental challenges, including those that lead to the emergence of drug resistance. In the future this knowledge will ena
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TWISTING THE BOUNDARIES: ROLE OF TOPOISOMERASE 1 AT THE NUCLEAR LAMINA' under Horizon 2020.

assistant: **Concept**

When DNA is transcribed or replicated, torsional stress accumulates on the double helix. This tension must be dissipated by spreading it along the DNA fiber, or it must be removed altogether. One of the main factors responsible for the removal of such stress is DNA Topoisomerase I (Top1), an important target of cancer chemotherapy. When Top1 activity is lost, torsional stress accumulates on transcriptionally active genes and can lead to the formation of non-canonical DNA/RNA hybrid structures called R loops. These structures are emerging as important regulators of genome function and stability.  By genome-wide mapping of R loops in human cells, I recently found that depletion of Top1 leads to a marked R loop stabilization, specifically on genes that are anchored to the nuclear lamina. This strongly suggests that attachment of DNA to the nuclear lamina may prevent dissipation of torsional stress, but how this works is still largely unclear. I propose to investigate the causal relationships between torsonal stress, Top1, R-loops and nuclear lamina attachment, taking advantage of a suite of unique genomics techniques developed in the host lab. Specifically, I will: 1) Develop two novel reporter assays to probe the effects of chromatin context (in particular lamina associated chromatin) and Top1 on torsional stress and R loop formation, at thousands of locations in the human genome. 2) Investigate if and how Top1 regulates DNA/nuclear lamina contacts by by means of a novel version of the powerful genome-wide DamID mapping method with much-improved time resolution.  My expertise in Top1, R-loops and DNA topology combined with the unique genomics methodologies in the host lab, as well as their expertise in lamina-associated DNA,  will lead to a unique synergy that should resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Circular solutions for fishing gears' (SEARCULAR) under Horizon Europe.

assistant: **Objectives**

SEARCULAR aims at reducing the amount of marine litter and microplastic from the most relevant European fishery contributors (demersal trawlers, demersal seiners, tropical tuna purse seiners) and to introduce circular economy practices within the fishing sector value chain including ports, by fostering behavioural change. SEARCULAR will do this by developing/testing/validating 4 close-to-market sustainable and circular solutions (TRL7-9). Three of the solutions are related to the use of more sustainable materials as alternatives to the traditional non-circular plastic used in fishing gears: Solution#1 proposes a dolly rope made of recycled polyamide (rPA) from discarded fishing nets (thus it is focused on circularity and more durable materials), Solution#2 is based on certified marine-biodegradable materials for demersal seine ropes (the focus is on less impact gears), Solution#3 represents an eco-designed biodegradable drifting Fish Aggregating Devices (dFADs) used by tropical tuna purse seine fishery. And Solution#4 proposes an End-of-Life (EOL) fishing gears solution for ports by promoting a replicable management system that enables the pyrolysis of EOL fishing gears for a plastic2plastic application. The 4 solutions will be tested under real conditions: onboard commercial vessels (Solutions 1-3) and for the Basque country region (Solution 4), and they will be validated by stakeholders. Therefore, SEARCULAR solutions eliminate waste generated from fishing gears, circulate materials and regenerate nature.""


**Keywords:** Pirolisis, Logistics, Fish Aggregating Devices (FAD), Dolly ropes, Danish Seines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The European network of Women web Entrepreneurs Hubs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

It is generally acknowledged that the web entrepreneurship sector can contribute significantly to the competiveness and economic growth of countries and regions.  However, Europe is clearly lagging behind given that even though there are lots of European web start-ups, most of them rarely grow up to become global leaders. In this context, the position of women seems particularly weak given that only a very small percentage of them are web entrepreneurs.  Taking into account the limited development of web entrepreneurship in Europe as well as the limited participation of women in the web economy the WeHubs project seeks to create a favourable environment for women web entrepreneurs, by linking together local fragmented ecosystems nodes, and foster networking and exploitation of synergies, into the first European Network for Women Web Entrepreneurs Hubs.  In this respect the project is aimed at providing a strong support to women web entrepreneurs and existing web entrepreneur’s ecosystems enabling the latter to provide dedicated services to women.  As a result the project will foster the creation and scaling of web start-ups created by women (impact on women), strengthen the existing web entrepreneurs ecosystems through networking and complementary services (impact on ecosystems) and support the emergence of a dynamic European ecosystem for women web entrepreneurs contributing to the formulation of relevant policies, support the implementation of start-up Europe initiative and the wider enforcement of the European digital sector (policy impact).


**Keywords:** Web entrepreneurship, women web entrepreneurs, ecosystem nodes, motivation and encouragement, Startup Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Marketing server upon internet/intranet' under Fourth Framework.

assistant: **Concept**

The geomarketing business has been in full expansion these last years (+22% in '95). This expansion is a market answer to a wide range of needs- to enhance the management of networks- to arbitrate between delivery channels- to increase the level of motivation and responsibility at local level- to develop new micromarketing tools- to shift from a mass market strategy to a local market strategy.These needs are relevant for all economic sectors and critical for bank insurers and services distributors. Today, the geomarketing expansion suffers from various constraints:- diffusion of new technology (GIS), able to support a demand of non-geographic expert in a professional information service environment;- difficulty of linking specialised and complementary tools like GIS for spatial information management to statistical tools for extracting, analysing and enhancing the available information;- difficulty and cost of giving numerous local users access to sophisticated tools;- difficulty and cost of building specialised databases with a detailed market information.The strong development of Internet and the forecast of stronger development of Intranets bring a decisive element to build an efficient technological solution: MARKSERV. Captimark in collaboration with the University of Caen has already built a demonstration model of what MARKSERV can be. This model, although very basic, illustrates the capability of such a product when based on professional standards.MARKSERV has the following strengths:- It addresses directly the technological problems limiting the efficient use of spatial data in Europe.- It offers a complete solution built on an existing product..- It introduces significant innovation, such as the approach to distributed services around geographical information in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Plurals, Predicates, and Paradox: Towards a Type-Free Account'.

assistant: **Innovation**

This project aims to transform our understanding of the logical paradoxes, their solution and significance for mathematics, philosophy and semantics. It seeks to show that some of the key inferences in the paradoxes should not uncritically be blocked, as is customary, but rather be tamed and put to valuable mathematical, philosophical and semantic use. By adopting a richer logical framework than usual, the paradoxes can be transformed from threats to valuable sources of insight. When discovered at the turn of the previous century, the paradoxes caused a foundational crisis in mathematics. Many logicians and philosophers now believe the crisis has been resolved. This project denies that an acceptable resolution has been found and aims to do better. A strong push remains towards paradox. This push arises from the widespread use of (and need for) higher-order logics (HOL), which allow quantification into the positions of predicates or plural noun phrases. Phase I seeks to reveal greater similarities between HOL and set theory than generally appreciated. Phase II explores four arguments that HOL collapses to first-order logic, i.e. that every higher-order entity defines a corresponding first-order entity. These arguments are generally ignored as they threaten to reintroduce the paradoxes. But we show that a properly circumscribed form of collapse is a valuable source of mathematical and semantic insight. Phase III examines controlled forms of collapse using notions of modality and groundedness. This enables us to motivate ZF set theory and valuable semantic theories, explain the nature of cognition about sets and properties, and show that mathematics cannot be fully extensionalized. Phase IV applies these insights to solve the paradoxes and criticize influential uses of HOL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Further development of organic farming policy in europe, with particular emphasis on eu enlargerment' (EU-CEEOFP).

assistant: **Concept**

This project will examine the future development of Organic Farming Policy (OFP) in Europe. The primary concern of the project is to guide the further development of European OFP, including policy instruments and institutions that address the full range of conditions necessary for organic growth. Recommendations for the further development of OFP will be based on analysis ofa) the development of Organic Farming (OF) in selected EU countries under implementation of EU Agenda 2000 andb) the pattern of development of OF in CEE Accession nations.The relationship between results from the two analyses will assist determining the likely impacts of EU enlargement on OF development in EU and CEE nations. Recommendations will focus on outlining further developments to OFP that would promote OF in both existing EU nations and in Central and Eastern European (CEE) states in a complementary way.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Border Change and Local Development in Europe and Beyond' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Border changes through secession, unification, and territorial transfers have reshaped almost all states in Europe since 1815 and revisionism continues to threaten states worldwide until today. While the causes of border change are well-studied, its consequences for local development have been much less scrutinized. BORDERS therefore analyzes the mechanisms through which border change has affected local development in Europe and beyond over the past two centuries using new theory, data, and methods.BORDERS’ central contributions are delivered by four work packages (WP). WP1 develops a theory of the impact of border change on socio-economic development through changes in local ethnic demography, economic market exchange, state capacity, and ethnic politics. WP2 produces unparalleled longitudinal data on local development across Europe since the 18th century by using machine learning to measure village-level development from historical survey maps. Additional data from historical administrative and geographic sources will be collected to capture the relevant causal mechanisms. WP3 empirically examines the theory and mechanisms developed in WP1 across the more than 200 border changes in post-1815 Europe using methods for causal inference in geographically disaggregated panel data. WP4 tests the applicability of the theory across a global sample of border changes since 1945, examines contextual factors that explain variation over time and across cases, and investigates divergences with effects observed in historical Europe.In times of renewed border contestation, BORDERS contributes new theory and robust evidence on the local effects of border change in Europe and beyond. The project enriches debates on long-run development and provides data on historical development in Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel phases in quantum gases: from few-body to many-body physics' (NOMBQUANT).

assistant: **Innovation**

The project is aimed at developing new methods to create ultracold gases with unexplored many-body properties, and we construct the theory to realize the proposed opportunities. We intend to develop new ideas to induce resonant, long-range, and many-body interaction between particles. This includes novel near-zero-field Feshbach resonances in gases tightly confined to 1 or 2 dimensions that will enable the exploration of the physics of spinor gases in ultralow magnetic fields (<1mG). The idea is that the resonating state of the closed channel is a field-tunable confinement-induced weakly bound state. By the low field one avoids field-induced accumulation of particles in a given Zeeman state and encounters a variety of novel many-body states with interaction-broken spin rotation symmetry. The new resonances for polar molecules in 2 dimensions (layers) are provided by their coupling to the interlayer 2-molecule bound state. This allows one to reduce the short-range 2-body interaction making a 3-body repulsion important for bosons, so that the resulting many-body states can be various supersolids. It is further proposed to work on intriguing open problems. The creation of an itinerant ferromagnet of 2-component fermions is blocked in 3D by the formation of weakly bound dimers at the strong intercomponent repulsion required by the Stoner mechanism. In 1D this state is impossible for contact interactions. Our idea is to include an antisymmetric interaction (p-wave in 3D), which can practically make the ground state ferromagnetic. We then focus on non-conventional transport of rotational excitations of polar molecules randomly distributed in a deep optical lattice. The amplitude of hopping of an excitation from an excited to a ground state molecule decays as a cubic power of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Human Subject Research and Medical Ethics in Colonial Southeast Asia' (COMET), addressing dissemination and exploitation.

assistant: **Impact**

This project is a comparative study of human subject research in colonial Southeast Asia in the period 1890-1962. While the most (in)famous instances of medical scientists conducting unethical experiments on human beings took place in Nazi Germany and the United States, advances in medicine more broadly relied on research on non-consenting human subjects – often in colonial contexts. Doctors in the Dutch, British and American colonies in Southeast Asia too did medical experiments that discounted the well-being of their research subjects but the region also has some of the earliest examples of informed consent. This project will be the first to study these practices.The key objective of the project is to define and explain the different ethical practices in human subject research in colonial Southeast Asia. To achieve that objective the project aims (1) to understand the nature and reveal the scope of human subject research in Southeast Asia, and (2) to conceptualize the ethical regimes in the colonies in order to explain differences between ethical decisions of doctors in diverse socio-cultural settings. To bring these issues into the present, the project also (3) examines the afterlife of colonial medicine in the postcolonial world to explore how the legacy of medical research could be used ethically today. The project’s hypothesis is that the changing context of colonial politics, research infrastructure, religious beliefs, professional (tacit) codes – what I call the ethical regime – together with local circumstances, explain these changes.The project has a novel, anthropologically grounded approach and a three-way comparative method that includes comparisons between the Dutch East Indies, British Malaya and the (American) Philippines, and between colonies and their
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bypass the g2/m checkpoint in cancer therapy - inhibition of the interaction between cdc25 phosphatases and 14.3.3 proteins' (1994-1998).

assistant: **Concept**

Research objectives and content In order to increase the cytotoxic effect of drugs that are currently being used in cancer therapy we propose to bypass the G2/M checkpoint that is activated in response to DNA damages. Thus, the cells will enter a programmed cell death program, an effect that will increase the cytotoxicity. In this aim we propose to screen peptide library using the two hybrids and the phage display strategies, in order to identify peptides dissociator of the interaction between the cdc25 and 14.3.3 proteins, which is responsible of the cell cycle arrest in G2/M checkpoint after DNA damage. Training content (objective, benefit and expected impact) This training will be a good opportunity for me to acquire experimental experience in an international laboratory and to follow up my training about the regulatories mechanism of the cell cycle and of the cell proliferation. The identification of peptides with a dissociatory effect on the cdc25/ 14.3.3 complex formation could led, through a molecular modelling approach in association with 'drug design' strategies, to propose new peptidomimetics that could be use in future cancer therapy. Links with industry / industrial relevance (22)