RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Validating technical assumptions for a multi-tenant mobile multiplayer game backend platform.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Daogames enables independent game developers to transform their mobile games into sustainable businesses and valuable entertainment. To achieve this we aim to provide developers with a cloud platform which enables easy integration of cloud-connectivity and multiplayer features into mobile games.The mobile games market has become the main driver of the games industry, growing to USD 22 billion worldwide revenue in 2014 with 200.000 mobile games on the market. 66% of the revenue on mobile devices is generated by games. The top performing games leverage cloud-connected features and player interaction, are operated and managed through a cloud backend and have been developed by large game studios. Independent game developers can’t easily leverage these types of games because of missing technical know-how, high license and operating cost and longer time-to-market. We aim to provide independent game developers with a platform that removes these barriers, is easy to use and affordable. Indie game studios typically consist of 1-10 developers. This target group represents 99% of all mobile game developers worldwide, with a total of about 20.000 game developers (25% based in Europe). The daogames platform is unique and innovative, making previously expensive and complex technology available at low cost to the majority of this underserved market.We verified our MVP and started a beta program in 10/2014, with a growing number of indie game developers testing our platform. Our feasibility study aims to provide concrete numbers for important assumptions used in our business plan. We'll be designing a testable small-scale representation of our production system architecture. The final outcome of this study will be the re-assurance that our chosen production system architecture fulfil t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanofluidic Catalytic Reaction Imaging' under Horizon Europe.

assistant: **Concept**

How can we “see” a catalytic reaction on a single nanoparticle? While our eyes use visible light to create a vivid perception of our world, they are unable to resolve the nanoscale. Now imagine light yet allowing us to equally vividly see a chemical process and thereby enabling us to witness how structure or chemical composition of a single nanoparticle control the rate of a catalytic reaction on its surface. To date, the lack of a suitable technique prevents this ultimate level of insight at technically relevant conditions. At the same time, to gain such insight is the ultimate goal of catalysis science and a key enabler for the rational design of next-generation catalyst materials needed to address some of humanity’s grand challenges in the energy, environmental clean-up and health sectors. NACAREI therefore develops a  nanoimaging method that realizes this ultimate goal. As the key ingredients for achieving the necessary unprecedented resolution, it relies on the combined nano-confinement of reaction products in, and the ultrahigh optical sensitivity of, nanofluidic structures. Particular focus will also be put on the development of methods to fabricate or trap size-, shape- and composition-controlled single sub-10 nm metal nanoparticles inside nanofluidic channels by combining key traits of top-down nanofabrication and colloidal synthesis. The developed nanoimaging platform will be applied to scientific case studies related to catalyst function with respect to the roles of particle structure, surface state, chemical composition and interaction with the support, and thereby uncover the next generation of catalyst design rules. In the long term, I envision the developed nanoscale imaging platform to enable the study of other nanoscale processes, for example in biochem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Complex Cores for New Utilities'.

assistant: **Concept**

The current process using multi-part metal core tools to fabricate complex primary structural carbon fibre reinforced polymer (CFRP) components via resin transfer moulding (RTM) is costly and complicated. The proposed solution within the CoCoNut proposal involves the use of advanced water-soluble materials that will replace the use of metallic cores. The scope of the proposed project consists of the development of technologies using assets already tried and tested by the partners. It will include the production of a demonstrator part that will provide both a POC (proof of concept) demonstration of the feasibility of the technology, and production of a full-scale part based on the configuration of a composite landing gear part designed for the HECOLAG project, using RTM and incorporating cores designed for the current project. This is expected to drive the technology from TRL 3-4 to TRL 5-6. A comparison will be made between the new technology that will be designed, produced, and tested for the HECOLAG project and the existing Legacy technology based on metallic cores. The applicants have extensive experience both in advanced cores development and manufacturing, and in advanced aerospace composites production processes, in particular resin transfer moulding (RTM).


**Keywords:** cores complex injection RTM trapped tooling washable  mandrels
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An Innovative and Sustainable Spray Drying Technology' (SpeeDrying) under Horizon 2020.

assistant: **Objectives**

This proposal aims to widen the competences and skills of a young, excellent and ambitious researcher (Loredana Malafronte) by advanced training at one of the most innovative food engineering groups located at ETH - Swiss Federal Institute of Technology Zürich, Switzerland. The training will develop Malafronte's personal, technical and entrepreneurship skills, as well as widen her network of international contacts both in academy and industry. The research  project that will be carried out aims to develop a sustainable and innovative spray drying technology for production of highly functional powders from a liquid feed by combining electromagnetic (microwave and/or infrared) and convective heating. The advanced spray-drying technology is expected to improve drying efficiency in food, pharmaceutical and chemical industries, reduce energy consumption, and enable manufacture of flexible dryers and innovative dry products with high functionality. This work will build on knowledge developed by Malafronte during her PhD work and it will give to the candidate possibilities to learn a new scientific approach and how to develop more complex and innovative processes. A tailor processing approach, developed by Prof. Windhab, the main supervisor at ETH, will be used to extract Process-Structure Functions (PSF) and Structure-Property Functions (SPF) from the molecular- to macro-scale during electromagnetically assisted spray-drying. In addition to skills in conducting research, Malafronte will learn how to manage projects, communicate results effectively and commercialize research. This project will give Malafronte the possibilities to pursue a research career in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Statistical methods and software tools for the genetic analysis of monogenic and multifactorial diseases' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

- To develop parametric and non parametric methods of linkage analysis to handle more complex situations with the aim of elucidating the genetic mechanisms and gene-environment interactions in the etiology of multifactorial diseases. - To develop faster computing algorithms to facilitate the rapid fine location of genes causing monogenic disorders and to accelerate analyses with the complex methods developed for the genetic analysis of multifactorial diseases. - To validate the methods and algorithms through computer simulations.  - To implement these methods and algorithms in user-friendly computer programs to be ultimately merged into a unique modular package. - To make these techniques and computer programs easily available to the scientific community.Many disease genes have been identified via linkage analysis approaches which test for co-segregation within families of the disease trait with a random marker locus. At least 400 disease genes have been mapped by linkage approaches already, but the majority of these are genes for monogenic Mendelian diseases with simple patterns of inheritance. Now human geneticists are beginning to study the genetics of multifactorial diseases such as hypertension, diabetes, heart disease, multiple sclerosis, arthritis, and obesity. Multifactorial diseases are caused by multiple genes interacting with each other and with environmental factors. Identifying and characterising the genes involved in these disorders is a difficult task because it requires substantial resources including very large collections of family data, highly informative genetic markers which span the genome, and specifically developed statistical approaches which deal with multifactorial disease. As data sets on multifactorial disease have been generated, it has bec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ORogenic cycle revised: Post-subduction tectonics at A contineNtal marGin' in the context of a Horizon 2020 call.

assistant: **Objectives**

Subduction describes the process in which one tectonic plate descends into the mantle beneath an adjoining tectonic plate as a result of convergence. They play a fundamental role in the creation and evolution of the continents, the generation of new oceanic crust and the exchange of water between the Earth, oceans and atmosphere. Subduction zones are also the principal source of volcanic and seismic hazard around the globe. Despite having been the subject of intensive study by Earth Scientists from around the world, one aspect of the subduction cycle that has received little attention is the termination phase, where, for potentially a variety of reasons, the descent of the downgoing slab ceases. Given that all subduction zones have a finite lifetime, this process is likely to have profoundly influenced the way in which our continents have evolved, but to date no credible model has been developed for what might happen to the crust and upper mantle in such circumstances. This knowledge gap means that there is a unique and timely opportunity to provide new insight into this fundamental Earth process. I aim to make a step-change in our understanding of how post-subduction continental margins evolve and how the crust and upper mantle interact by combining seismic imaging, geodynamic modelling and geological observations in North Borneo (east Malaysia). The central objective of the proposal is to deploy a dense array of seismometers both onshore and offshore in North Borneo to record local and regional earthquakes, as well as ambient seismic noise, in order to image the underlying crust and mantle at high resolution. Our new multi-disciplinary study will allow us to build a model of how the continental lithosphere responds to subduction termination. As well as filling an impo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The biogenesis of tail-anchored membrane proteins: knowledge and exploitation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Even in the simplest cells, the integration of proteins into a biological membrane is a complex process that is frequently coupled to ribosomal protein synthesis, and requires the coordinated actions of several additional cellular machines. The de novo recapitulation of such a complex process is well beyond the scope of our current technical abilities. Indeed, the techniques that are used to create novel proteoliposomes, for drug delivery, and artificial membranes, for synthetic biology, are extremely crude. A common approach is to mix detergent solubilised proteins with lipids, and then remove the detergent to form proteoliposomes, a process that is inefficient and difficult to control. Another major limitation of this approach is our inability to alter the protein complement of the resulting phospholipid-bilayers once they are formed. It is precisely this issue that our consortium will address, by creating a flexible and ubiquitous platform that is ideally suited to incorporating proteins into preformed liposomes. To achieve this novel and innovative breakthrough in liposome technology, we will harness the unusual ability of tail-anchored proteins to be inserted into pre-existing membranes. This technique will enable the production of customised liposomes that can be tailored to optimise drug delivery, and allow the creation of multifunctional artificial membranes for the newly emerging field of synthetic biology. The overriding ethos of our network is to develop a robust platform for the application and exploitation of tail-anchored membrane proteins based on a framework that develops and enhances fundamental insight and training in this new field of research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photonic Metaconcrete with Infrared RAdiative Cooling capacity for Large Energy savings' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project envisions a new science and technology that turns low-tech concrete and cement-based materials into high-tech functional photonic metamaterials. In particular, the MIRACLE project will construct and test a revolutionary Photonic Meta-Concrete (PMC) whose response to light will be engineered for exhibiting radiative cooling ability; i.e. the PMC will be able to expel heat from buildings to the outer space without any extra energy consumption. Though this ambitious challenge can have a big impact in the Nearly-Zero-Energy-Buildings (NZEB) uptake,  the concept of PMC transcends this particular application, with multiple implications in avenues like solar cell-technology or communication technologies, for example. Radiative cooling technology utilizes the atmospheric transparency window to passively dissipate heat from the Earth to outer space. This technology has attracted wide interest from both fundamental and applied sciences, due to its a priori potential in multiple applications like building cooling, renewable energy harvesting, or even dew water production. However, currently the development of this technology is in a bottleneck, where the scientific ideas have negligible potential impact in any real-world energy solution. In this context, the MIRACLE consortium proposes a considerable advance in the state-of-the-art because it will address for the first time an effective and fully scalable solution based on steel microfibre reinforced concrete ! The idea of MIRACLE is to propose new designs where an ordered arrangement of the steel microfibres can work in combination with hierarchical porous structure of concrete as a PMC. For this challenging objective, advanced optimization methods based on deep learning technologies will be employed at the design le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The national implementation in the EU of the externe accounting framework' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives This study aims to disseminate and implement the ExternE Accounting Framework of the EC for the assessment of external costs of energy fuel cycles for power generation in the EU (15 member states) and Norway. A network of scientific institutes in all these countries has been established. Fuel cycle externalities are the costs imposed on society and the environment that are not accounted for by the producers and consumers of energy, i.e., that are not included in the market price. They include physical damage to the natural and built environment as well as impacts on recreation, amenity, aesthetics and other contributors to individual utility. The Joule programme launched in 1991 developed a bottom up methodology to quantify these externalities. It is the objective of this project to apply this methodology to different fuel cycles in EU countries. This will allow the constitution of a database, in which the externalities of different fuel cycles in the EU will be compiled. It will also allow for the aggregation of results at a national level. Technical Approach This methodology has been successfully developed and reviewed and has received a recognition by both the scientific community and the European Institutions. It was considered by the European and American experts in this field as currently the most advanced project worldwide for the evaluation of external costs of power generation. The review confirmed the importance to take the site and technology specificity of externalities within each fuel cycle fully into account. This requires a completion of the national implementation phase which has started under the Joule II program. The objectives of the study lead to the definition of work packages: - Development of adequate training tools, software for imple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Design and manufacture of minimum energy forms of lightweight tensionmembranes'.

assistant: **Objectives**

Lightweight Structures comprising pre-stressed cable nets and textile fabricsprovide efficient load carrying systems and scope for dramatic architecturalexpression. The most complex and critical factor in their design is their shapedefinition, derived from a 3-stage procedure: (i) form-finding, i.e. finding ashape consistent with pre-stress and boundaries (ii) patterning, i.e.production of a 2-dimensional cutting pattern (iii) static and dynamicanalyses. The aim of the project is to develop the most efficient computationalmethod encompassing all three stages of design. The outcome of the projectwill be a proposal for development of a computational design method for tensionstructures that minimises cost of analysis, produces optimal shapes ofmembranes and increases competitiveness of such products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Searching for TRans-eQTL affecting the risk to develop Inflammatory Bowel Disease' (TRIQ), addressing dissemination and exploitation.

assistant: **Impact**

Inflammatory Bowel Disease, including Crohn’s disease and ulcerative colitis, now afflict close to 1/250 individuals in industrialized societies.  There is a pressing need for effective preventive means as well as curative drugs.   Cis-eQTL analyses are uncovering a growing list of genes that are perturbed by IBD risk variants detected by GWAS, constituting a list of prime drug targets for the pharmaceutical industry.  Cis-eQTL effects trigger downstream effects – both within the same (intracellular)  and other cell types (intercellular) – that culminate in disease declaration.  Some of these downstream effects are accompanied by changes in transcript levels referred to as trans-eQTL effects.  The aim of the TRIQ project is to take advantage of the CEDAR-II dataset – transcriptome data for up to 400 individuals in > 75 IBD-relevant cell types – to identify trans-eQTL effects that mediate IBD predisposition.  The genes that are perturbed by these trans-effect will include druggable targets that constitute prime targets for the development of new IBD therapies.


**Keywords:** eQTL analysis, Inflammatory Bowel Diseases, post-GWAS analysis, GWAS