RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Product Acquisition from Waste Streams' (PAWS), addressing dissemination and exploitation.

assistant: **Impact**

Objectives and content A key issue in the long term for manufacturing companies is to include resource recovery in their logistics chain. This suggests the take back of product at the end of life to re-use or recycle. However, the basic principles of costing, logistics and quality assessment of discarded goods are not at all understood. Current industrial research focuses mainly on design for material reclamation and disassembly. This research is necessary to reduce the costs incurred with the environmental requirements. In the long term, a substantial contribution can be made by developing new industries and markets for the re-use and refurbishment of products, rather than parts reclamation and waste disposal. Concepts such as secondary sourcing, end-of-life-cycle maintenance of product, which are currently very expensive for manufacturers, will typically be taken over by new SMEs, in partnerships with the original manufacturers. Issues for these new industries will include reverse supply chains, forecasting, product and process costing, financing structures, stocking policies, customer service, tracking & tracing, and environment. Neither the business concepts nor the information systems for these industries are available at present. PAWS will therefore focus on these issues, rather than design for recycling, which is covered by other projects. The first industrial objective of this project is to provide industry with an understanding of resource recovery in terms of business models and objectives. Through case studies, PAWS will develop a typology for resource recovery and business models for each type in the typology. The second industrial objective of the project is to provide industry with the concepts needed to develop information systems that support resource re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quality control for household appliances by on-line evaluation of mechanical defects' (MEDEA) under Fourth Framework.

assistant: **Objectives**

Manufacturing companies of washing machines(WMs) and dishwashers(DWs) need an automatic on-line inspection system to accurately monitor the mechanical characteristic of all their products. Present on-line inspection methods are scarcely effective because human operator dependent and not sufficiently reliable. The main objective of this project is twofold: a) to have diagnostics of mechanical defects by means of vibrations analysis, thus allowing the percentage of faulty products to decrease b) to assure and improve the products quality as regards to the emitted noise/ vibrations level. This will happen because the knowledge of defects permits a continuous improvement of the production process. WMs/DWs manufacturers agree that at present there are no means to reach the 'zero defects' goal. This project aims to approach this goal providing a prototype test station for house-hold appliance on-line inspection, capable to give a global evaluation of the vibroacustic quality of the machine under test, classifying it into two classes, product complying or not to specifications, according to a pass or fail quality control strategy. The system is meant to provide a non-operator dependent evaluation of the machine vibroacoustic quality. It has to be reliable and effective in identifying faulty products and classifying the defects at the end of the production line, with a confidence level more than 99%. The maximum time required for every test should be less than 2 minutes in order to be acceptable by industry. The prototype test station will embody and rely on two main technological developments. - A non-invasive optical sensor network for multipoint vibration measurement, based on integrated optics and fiber optics; the sensor network will measure vibrations on 4 to 8 points in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Imprints of Magnetic fields in Exoplanets'.

assistant: **Innovation**

The fast-growing sample of thousands of extrasolar planets is unveiling an amazing variety of properties. It represents an opportunity to shed light on long-standing physics and astrobiology issues from a much wider sample than our Solar neighbours, especially for what concerns the still unclear internal structure, only grossly constrained by observable values of mass and/or radii. Planetary magnetism and its long-term evolution is currently understood only partially for the Earth, at a lesser extent for Jupiter and other Solar planets, and is still elusive in exoplanets. The project focuses on magnetic fields as a key factor in shaping habitability and as a messenger of the internal composition and dynamics.For terrestrial planets, long-lasting, strong enough magnetic fields are arguably a key factor to guarantee habitability, but we are not even sure about how the Earth’s magnetic field has survived for so long. Magnetism leaves other detectable imprints in giant planets. A quest for the first exoplanetary Jupiter-like magnetospheric emission in radio is on-going, but the search needs to be driven by a reliable prediction of the most likely emitters. Magnetic fields can delay the cooling via Ohmic dissipation and could explain the often observed inflated radii in hot Jupiters, but models are still incomplete. IMAGINE will simulate the long-term (Gyr) evolution of the exoplanetary magnetic fields, coupled with a cooling model, and will assess the relevant imprints on their observables for a broad range of distinctive features mass, composition, irradiation, rotation.Combining a novel formulation, emission models and advanced numerical techniques partially imported and adapted from the scenario of magnetized neutron stars, on which the PI is expert, IMAGINE will predict
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Study of neuroligins in mice as animal model for autism' (NEUROLIGIN).

assistant: **Concept**

Autism is one of the most frequent cognitive disorders diagnosed in childhood. It affects more than 1 child in 1000, without any pharmacological treatment available to prevent or reduce their pain. Previous work of the applicant has already characterised several predisposition genes to this syndrome. Using classical human genetics approaches, an association between a gene coding an ionotropic glutamate receptor (GRIK2) and autism was identified. Moreover, two mutations in genes encoding neuroligins, NL GN3 and NLGN4, segregating in two independent families with autistic disorders, have been detected.Neuroligins are cell adhesion molecules that may contribute to the induction of synapse formation between neurons. They are located at the postsynaptic membrane of glutamatergic synapses, where they interact with beta-neurexins to form a transsynaptic dimeric complex. Recent results strongly suggest that dysfunction of glutamatergic synapses may be linked to a predisposition to autism and that autism could be due to an abnormality of neural networks. The proposed project intends to modify the expression pattern of neuroligins in mice, in order to examine the physiological significance of such changes on neuronal network, focusing on the role of Nlgn3 and Nlgn4 in brain morphology, function and animal behaviour.This approach will shed light on the role of neuroligins during synaptogenesis and will point to molecular mechanisms involved in autistic disorders. The Max Planck Institute for Experimental Medicine (Goettingen) is a high-quality research institution to carry out such a project. Undertaking this project in a leading European laboratory allows the applicant to consolidate existing research skills, learn new techniques and qualify him for an independent research career
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The GRASSHOPPER network: Jumping forward from preclinical development of pediatric cancer drugs to clinical implementation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Every year 16.000 children in Europe are diagnosed with cancer, and 2000 children (approximately 70 school classes) die from this illness. New therapeutic solutions are advancing rapidly however the optimization and implementation into clinical trials accessible for these children is lacking behind. New therapeutic interventions often don’t make it through the valley of death between preclinical development and clinical implementation. In addition, the accessibility between countries of new treatments varies largely. Therefore, the GRASSHOPPER consortium aims to create a multidisciplinary network of stakeholders in pediatric cancer development to boost implementation of new therapeutic interventions for children with cancer across Europe and beyond. GRASSHOPPER consists of 10 beneficiaries and 7 associated partners located in 16 countries: 6 academic European Comprehensive Childhood Cancer Centers (CCCC’s) and 3 non-European CCCC’s, 5 non-academic national leading Childhood Cancer Centers, 2 leading pharmaceutical companies and 1 non-for-profit drug developer. The consortium has 4 objectives: identification and preclinical validation of new immune interventions (1) and new molecular interventions (2), stimulating repurposing of available therapeutic interventions (3) and improving clinical validation of high potential therapeutic interventions for pediatric cancer (4). These objectives will be achieved by intersectoral secondments between the various beneficiaries and partners. The consortium expects that these objectives will lead to a strong international and multidisciplinary network, exchange of knowledge and expertise between sectors and countries and lead to highly skilled researchers, trained in pediatric and transferable skills, and with a large network for futu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biotransformations using baeyer-villiger mono-oxygenases', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The objective of the present project is to lay the scientific foundations necessary to achieve eventual commercial exploitation of microbial Baeyer-Villiger mono-oxygenases (BVMOs). This particularly exciting class of enzymes is able to catalyse regio- and stereo-specific oxidations which are difficult to achieve by chemical methods. The enantiomerically pure products are intermediates for the potential manufacture of fine chemicals of high value in the pharmaceutical and food industries. We believe that it is crucial that these very promising biocatalysts are exploited for the benefit of European industry.  The aim of this proposal is to develop a multidisciplinary approach for the production, fundamental study and potential application of these enzymes. This project is timely not only because of the potential values of the products that could be made using BVMOs but also because within Europe we already have world class laboratories working on these enzymes. To capitalise on this expertise it is vital that these laboratories join together in this project, which will bring together skills in organic chemistry, enzymology, molecular biology and genetics, and Xray crystallography with biochemical engineering in an integrated way to demonstrate the feasibility of use of Baeyer-Villiger monooxygenases on a large-scale and the versatility of these biocatalysts for producing chemicals of industrial interest  This will involve (i) undertaking cloning and expression to increase enzyme synthesis and express the desired enzymes in suitable hosts, (ii) scale up production of microorganisms to pilot scale (25-300L), (iii) characterisation of reactions by evaluating the properties of substrates, products and catalysts and the reaction characteristics and kinetics, (iv) establishing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Colonization resistance: training and research towards microbiome derived solutions to foodborne disease' under Horizon 2020.

assistant: **Concept**

The COL_RES network comprises a world-leading group of investigators that will investigate the mechanisms by which the gut microbiota protects against serious foodborne pathogens (Salmonella, E. coli, Listeria, Citrobacter and Campylobacter) and lead to the identification of next generation probiotics that can protect against multiple infectious agents. Through intersectoral industry-academia secondments the network will provide state-of-the-art training for early stage researchers (ESR) preparing them for problem solving and entrepreneurial roles in industry and society and underpinning cutting-edge research in infectious disease in the EU. Food and water borne diseases cause 23 million illnesses in the European region with 5000 deaths per annum and represent an increasing challenge to the health of the EU and global population. Through studying different pathogens using shared approaches the COL_RES network will undertake a network-wide approach to identify overlapping mechanisms by which members of the gut microbiota provide a barrier to infection through the phenomenon of Colonization Resistance. The work will utilise a systems-based approach by exploiting existing research models at world-leading laboratories combined with phageomics, metabolomics and bioinformatics to generate multi-omics data that will uncover both pathogen-specific and shared mechanisms by which the gut microbiota protects against foodborne pathogens. The work will inform the selection and testing of specific next-generation probiotic candidates that can protect against foodborne infections, with potential for further development by our industry partners. Thus, the network will enhance training through world-leading research via cross-sectoral industry secondments in an actively entrepreneurial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A radically new approach to laser additively manufacture metals with periodic coarse-fine grain structures for breaking the strength-ductility trade-off'.

assistant: **Innovation**

Periodic lamellar metals (PLMs) with coarse-to-fine grained microstructures provides a new way to overcome the strength-ductility trade-off through the accumulation of geometrically necessary dislocations and hetero-deformation induced hardening, demonstrating great potential to future engineering applications. As an important component of Industry 4.0, selective laser melting (SLM) has become a powerful industrial tool in EU and worldwide. However, to date, few to no efforts have been devoted into the experimental investigation of PLMs made by SLM. Only one modeling work briefly discussed the strengthening and toughening mechanisms of the PLMs. Thus, the fundamental knowledge associated with the microstructures and properties of SLM PLM parts is still lacking. Such lack of critical knowledge is a hard barrier for the development of high-performance PLM engineering parts. To this end, this project proposes to adopt SLM for the fabrication of novel PLMs through adding alloying elements into starting powders. The key aspects of this proposal are as follows: 1) Design and fabrication of PLMs; 2) Microstructural tailoring and anisotropic tensile evaluation; 3) Characterization of the strengthening and toughening mechanisms; 4) Prediction of anisotropic tensile properties by machine learning. This project aims to evolve the current in-situ alloying strategy employed during SLM, enable the tailoring of heterogeneous microstructures, and provide an excellent strength-ductility balance over the homogeneous-grained counterparts. It is expected that the new knowledge generated from this project will facilitate the 3D printing of high-performance metals. This proposal involves both the transfer of knowledge to the host institution and the training of the candidate in new advanced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Foetal Intestinal Stem Cells in Biology and Health'.

assistant: **Innovation**

There is currently no medical cure for the millions of individuals affected by inflammatory bowel disease (IBD). These patients suffer from bleeding along the gastrointestinal tract due to epithelial ulceration, which causes severe abdominal pain, diarrhoea and malnutrition. This is due to the severely compromised integrity of the intestinal epithelium. I propose that patients with IBD will benefit from an intestinal epithelial transplant.The objectives of this research programme are two fold. Firstly, I propose to perform preclinical testing of human intestinal epithelium to pave the way for their inclusion in clinical trials for IBD patients. This will be based on a combination of state-of-the-art cell culture methods with novel transplantation methodology. By combining analysis of intestinal epithelial cells from various developmental stages, I will be able to identify the most suitable source for transplantation and define how adult stem cells are specified in the tissue. Secondly, I will utilise an in vitro culture system to identify the transcriptional networks responsible for the maturation of the foetal intestinal epithelium. Tissue maturation currently constitutes a major roadblock in regenerative medicine as cells derived from foetal and pluripotent stem cells have foetal properties. Understanding this process will therefore improve our ability to generate sustainable sources of cells for transplantation, which is pivotal for future therapies relying on regenerative medicine and in vitro modelling of diseaseThe proposed research programme will have significant clinical and biological impact. Clinically, it provides the framework for initiating clinical trials for patients with IBD and protocols to obtain mature adult epithelium for in vitro disease modelling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Vaccines as a remedy for antimicrobial resistant bacterial infections' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Antimicrobial Resistance (AMR) is perhaps the most emerging alarm in health. It already causes 700,000 deaths per year and the forecast for 2050 is 10 million deaths, more than cancer today. WHO, UN General Assembly, World Bank, G20,  EU, UK and USA governments call  for new antibiotics, but  the pipeline for new antibiotics is not very promising.  Here we propose to use new technologies to develop human monoclonal antibodies and vaccines against three AMR  bacteria such as gonococcus, pneumococcus and E.coli.  The technology defined as reverse vaccinology 2.0, already successful for viral infections, will be used for bacterial vaccines.  Taking advantage of the recent possibility of high throughput cloning of human B cells from convalescent or vaccinated people we aim to find targets difficult or impossible to be discovered using conventional technologies.  B cells will be cloned from people convalescent from target infections  and from people vaccinated with Men B vaccine which confers some protection against gonococcus. The antibodies produced by the clones will be screened for their ability to bind, intoxicate  or kill bacteria using a novel high-throughput microscopy platform that rapidly captures digital images  and also with conventional,  lower throughput technologies such as bactericidal, opsono-phagocytosis and FACS assays. The selected  antibodies, will be expressed as full length and used for passive immunization in animal models and tested for protection in vivo.  Finally, those antibodies that will provide the best protection in the above assays, will be used to identify the recognized antigens. Selected antigens will be expressed and tested in vaccine formulations. Fab fragments can be used to make co-crystals with the antigen and determine the crystal st