RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'A sequential high throughput ion channel screening system for drug discovery in neurological and psychiatric disorders'.

assistant: **Innovation**

ION is a co-operative research proposal for the development of an innovative system capable of an efficient screening of candidate drugs on a wide set of targets (ion channels) involved in important neurological and psychiatric disorders, e.g. depression, Parkinson, epilepsy, migraine and pain. The proposers are a group of SMEs which includes technological companies and end users in the pharmaceutical sector. The RTD partners are required to provide the knowledge and the research capabilities to address the selection and optimization of the cellular targets and to validate the outcomes of the system in relation to the results of in vivo models of the pathologies of interest. However, an important contribution of the RTD partners will be to design a suite of innovative software agents for data analysis and experimental planning. The role of these agents is essential to achieve real high screening throughputs. The ION project will optimize the performance of a sequence of screening experiments instead of focusing on the execution of a single experiment. With respect to the current state of the art, the proposed development will introduce two important innovations. First, easy access to a large set of targets and to an efficient drug discovery process, exploiting a well designed and implemented library of starting molecular structures. Second, it will develop innovatively the analysis of the output and enable future experiments to be planned more effectively by introducing intelligent software agents interpreting the outcome of an experiment and planning the next experiment of a drug discovery screening sequence. The proposers estimate a large market in the EU, USA and Japan for their future products due to the expanding pharmaceutical research in the considered disorders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A custom lock chip for compact NMR'.

assistant: **Objectives**

Nuclear magnetic resonance is an important chemical analysis method, because of its inherent chemical specificity, its versatility to extract molecular information, and its absolute accuracy. The market has been dominated by large superconducting NMR magnets with price tags of many 100k €. The emergence of less expensive low field compact (tabletop and portable) NMR spectrometers, based on the use of permanent magnets, with price tags around a factor of 10 lower than superconducting magnets, brings a drastically lower cost-of-ownership, and the significantly lower need for external support, maintenance, and lack of liquid Helium, which is opening up new applications and huge new markets for NMR.Compact NMR spectrometers, mainly used for teaching but targeting professional applications (e.g. real time process monitoring in chemical factories), have very cramped magnet bores (15 mm cube) mainly needed for the generation and detection of analyte signal. The magnetic field strength of their permanent magnets is strongly temperature dependent, so that the proportional NMR frequency drifts during measurements that are taken over extended time periods, which can lead to erroneous resonance results and is a major challenge, especially for forensic applications, or applications in factories. The remedy is to detect the temperature-dependent frequency shifts of a special lock substance, which is typically mixed into the sample, but cannot be done in the case of factory automation applications.This represents a big barrier for the introduction of compact NMR into many professional applications.Our miniaturized NMR detector, entitled LockChip, provides an ideal solution for all aspects. Its extremely compact size, easily fits side-by-side with the vendor NMR detector, with only two
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Advanced tools for developing highly realistic computer games'.

assistant: **Innovation**

Recent improvements in graphics hardware and CPU power have allowed computer games to implement more and more realistic computer graphics techniques. This encounter between a massive consumer market and the computer graphics technology is significantly boosting both fields.Computer graphics play a key role in providing computer games with the ever-increasing realism demanded by game players. Visibility, geometry, and lighting are some of the main areas involved in the development of a computer game. Hence, this project aims at developing new tools that will dramatically increase the realism and visual quality of computer games in these areas. New methods for computing visibility, both in a pre-processing step and on the fly, will be developed. They will be mainly used in highly dynamic and interactive outdoor scenes. In the domain of geometry, new specially fitted multiresolution models for complex geometries, such as plants and trees, will be created. To improve lighting simulation in digital games, real-time realistic global illumination effects will be provided.The tools will be developed around the software that sits at the core of a computer game, the 3D engine. To achieve its goals, the consortium brings together European computer graphics research groups and game companies. As computer games techniques are very close to the ones used in the fields of Virtual Reality and simulation, two companies from these sectors also take part in the project. The modules developed by the research groups will be validated and tested by the game companies, and integrated into their in-house rendering systems to provide demonstrators showing the viability of the developed methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Violence and Labour Discipline in Early Modern Britain' in the context of a Horizon Europe call.

assistant: **Objectives**

A 2010 report by the European Agency for Health and Safety at Work (EU-OSHA) notes that work-related violence is a ‘serious issue’ facing workers today. It also results in ‘substantial’ economic losses, through workers’ demoralized absenteeism and reduced productivity. Work-related violence, however, is not a new phenomenon; it has a history. VIOLLAB seeks to provide the first analysis of the causes and consequences of one type of work- related violence in Britain, c. 1550-1800: disciplinary violence. It defines ‘disciplinary violence’ as fatal and non-fatal physical violence (e.g., beatings) that employers or managers used to correct workers’ infractions and to instil a sense of discipline in them. Combining methods from social, economic, and labour history with analytical insights from the sociology of work, VIOLLAB uses a range of sources to shed new light on how disciplinary violence influenced contemporary practices and theories of labour management; (gendered and aged-based) experiences of work; and the legal system's mediation of worker-employer relations. By analyzing the causes and consequences of disciplinary violence across different sectors of the British economy as it was transitioning to agrarian and industrial capitalism and becoming increasingly reliant on unfree labour for the production of colonial commodities, VIOLLAB aims to make transformative contributions to scholarship on work, labour relations/discipline, and the law in a period before the existence of modern labour protection laws and workers’ organizations, and to raise public awareness about problems of work in the 21st century.


**Keywords:** Early modern history,  labour history,  labour relations,  legal institutions,  work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Promoting the penetration of agrobiomass heating in European rural areas' (AgroBioHeat), addressing dissemination and exploitation.

assistant: **Impact**

AgroBioHeat project aims to produce a mass deployment of improved and market ready agrobiomass heating solutions in Europe. Agrobiomass is a large, underexploited and indigenous resource, which can support the achievement of the European Energy and Climate targets, while promoting rural development and circular economy. AgroBioHeat actions will take place mostly in 6 EU countries (GR, ES, FR, RO, HR, UA; 5 EU28+Ukraine) where extensive engagement actions are foreseen. Engagement and matchmaking actions will lead to trigger more than 80 initiatives on agrobiomass for heat, 8 of which will be closely accompanied. To generate trust to market actors, the project will detect more than 100 cases running on agrobiomass and 12 will be approached, documented, visualized and visited by potential early adopters. Simultaneously, the project will perform more than 44 tests, covering different market heating technologies and agrobiomass in order to generate reliable data on its emissions and operational performance, and to show the market and community the existing improved technologies. On the EU level, these results will contribute to the anticipated review of the Ecodesign regulation for agrobiomass boilers, while providing suggestions for suitable emission limits in the 500 kW-1 MW range facilities; thus a harmonization of EU legislation will be achieved. Strategic plans for the deployment of agrobiomass for heating market will be drafted and discussed with more than 240 policy makers in the 6 countries. Promotion of the market includes agrobiomass corners at 15 fairs and a dedicated Observatory tool to visualize cases and technology. 60 technicians from ESCOs and installers in the 6 countries will be trained to be ready to adopt mature agrobiomass heating solutions. Social resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'BODIes of CONtact: Identity negotiations and biocultural effects in the Roman colonies of Macedonia, Greece' (BODICON) under Horizon 2020.

assistant: **Objectives**

BODICON examines processes of identity negotiations under colonial regimes by investigating the biocultural effects of conquest and colonisation of the Roman Empire. Representing a new generation of contact studies, the aim is to expand upon traditional elite/non-elite dichotomies or the focus on the health of conquered peoples toward how political transformations are incorporated by the human body of both the colonized and the colonizers. The research focuses on Roman Macedonia (Greece) and explores variable effects of colonisation by analyzing skeletal remains and burial patterns from the colony of Dion, the sacred city and pilgrimage site of ancient Macedonians. To achieve this aim, BODICON adopts for the first time a novel, multifaceted and holistic approach that combines bioarchaeology and current, sophisticated theoretical reflection on culture contact and admixture of populations with cutting-edge interdisciplinary techniques and methodological innovations from other scientific fields (paleodietary reconstruction, biodistance analysis, radiochronology). The Fellowship will offer to the Experienced Researcher (ER) the opportunity to acquire advanced intellectual and technical training and new skills in these fields and reach the research objectives. At the same time, the Fellowship is the timely opportunity for the ER to re-establish her career after a prolonged break and the ideal next step in order to re-enforce her research position. Finally, the creation of interdisciplinary networks as well as the dissemination and communication of the results to the scientific community and the broader public will first, contribute to the global understanding of the formation of modern national identities and second, explore the way historical data are used in contemporary p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'MR-based analysis, Indexing, and Retrieval of brain irON Deposition in Basal ganglia'.

assistant: **Objectives**

The aging in Europe necessitates more effective healthcare solutions especially in neurology, for it is one of the greatest risk factors for certain neurological diseases that impose significant financial and emotional costs to the society, est. 139 billion euros per year, not including the early stages of the disease, the emotional pain of the family, and the loss of experienced people from the workforce. Early detection is essential for alleviation or prevention, but it requires thorough understanding of the chemical changes in the brain. One of the most salient chemical changes regarding these diseases is a large amount of iron accumulation in the basal ganglia (BG) organ of the brain. Thus, it is often claimed that iron could be a potential biomarker for such diseases. This is very appealing because tissues with high iron concentration appear hypo-intense in the T2 contrast of MR images.To this effect, this project aims at developing:1) automatic brain MR image analysis methods to detect iron in the BG, and2) search and retrieval tools to be able to interpret brain MR images by the similarity of iron accumulation in a large population.These tasks involve multi-disciplinary research from the areas image processing, pattern recognition, databases, and clinical science. Compared with alternatives, MR-based brain iron detection and analysis is cost-effective, fast, and non-invasive. Moreover, we will develop search and retrieval tools to compare patients to correlate the iron-related features with neurological diseases and non-obvious pathologies.This does not exist today and is revolutionary. With Philips Research Video Processing Group, with its knowledge on image processing, and search and retrieval, and Sabanci University VBALAB, with pattern recognition, machine le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Environmental management of hazardous mining wastes and effluents' (ENVIMAN), addressing dissemination and exploitation.

assistant: **Impact**

Mining activities in Russia, associated with coal and mixed sulphide ores and concentrates generate every year, millions of tons of hazardous wastes, which are stockpiled in the vicinity of major cities (Moscow, Ekaterinenburg, etc). These wastes are oxidized, due to the action of precipitation, oxygen and bacteria and therefore, acidic waters and lactates with a very low pH and high concentrations of heavy and toxic elements are generated. These lactates migrate and contaminate severely major lakes, rivers and groundwater reservoirs, endangering thus the quality of the environment and the health of million of people. The present proposal, aims at the development and application of preventative and remedial technologies in ordera) to decontaminate the hazardous wastes,b) clean up the effluents andc) isolate hazardous waste dumps, in order to eliminate all these active pollution sources and protect the environment.The major deliverables of the ENVIMAN project are:- A detailed methodology for the characterization of hazardous solid wastes and effluents;- The development of an innovative risk assessment methodology;- The research on innovative techniques for the remediation of waste dumps and groundwater;- The in situ field application of a remediation technology in Russia;- The development of an integrated waste management scheme. The steps followed for the assessment of risk for each of the sites studied included:- Release assessment;- Exposure assessment;-Consequence assessment;- Risk estimation.In the risk estimation step, integration of the results derived from the waste characterisation step was carried out, in order to produce a quantitative estimate of the likelihood of risk for each of the sites studied. The model developed was programmed in a flexible computer la
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fluid, Ions and Radiation Ensemble in Integrated Plasma Modelling' (FIRE) targeting Seventh Framework.

assistant: **Abstract**

Fast particles and nanoclusters are produced directly in energetic plasmas, with desirable results as in nanopowder production and undesirable results as in debris and fast particle damage in EUV light sources. The phenomena cover diverse disciplines, from plasma physics to atomic physics, from radiation transport to quantum mechanics, from magnetohydrodynamics to non-equilibrium chemistry. Modelling tools and techniques that can describe the complete process, from plasma formation to formation of energetic particles and large nanoclusters, are lacking. The FIRE project aims to bridge this gap through the collective experience and transfer of knowledge between 3 partners, all actively engaged in different aspects of the overall issue. The knowledge and techniques to be transferred between the research institutions and industrial partner will enhance the capability of modelling of discharge and laser produced plasma to study the plasma dynamics, spectral emission and the creation of nanoparticles for the semiconductor industry and in nanotechnology. A state of the art 2-D RMHD code Z* will be upgraded to include recent advances in atomic physics and evolved into a hybrid 3-D code to address key issues in industrial plasmas. In depth research experience in laser produced plasmas and discharge plasmas will be exchanged. Complex radiation understanding in unresolved transition arrays and non-stationary ionization in mutlicharge ions will be combined. Within the FIRE project, the innovative code created will be used to design the EUV sources together with debris mitigation systems for the lithographic industry on one side, and to optimize the plasma-gas interaction for a cost effective, scalable technology for size-controlled nanopowder production on the other. The theoretic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Anticancer Chaotropic PVA Micelles with DNA-motif-mediated Targeting' to be submitted under Horizon Europe.

assistant: **Abstract**

In this project, I propose an innovative nanoscale therapeutic system for the optimized delivery of ellipticine (Elli), as a proof of concept, to cancer cells. Utilizing polyvinyl alcohol (PVA)—a biocompatible and biodegradable polymer—we will form micelles that encapsulate Elli within their hydrophobic core.To overcome challenges associated with cellular uptake and nanoparticle´s trafficking, we will functionalize the surface of the micelles with boron clusters to endow the nanocarrier with chaotropic activity, thereby facilitating enhanced membrane translocation. Further, we will integrate DNA motifs, specifically pyramid-shaped linkages (L-Py), into the boron cluster framework through coordination bonds. This modification is anticipated to permit selective targeting of cancer cells, thereby maximizing therapeutic efficacy while minimizing collateral damage to healthy tissues.The therapeutic efficacy of the resulting complex, formulated as Elli@APVA/n(L-Py)‒[B12Br12-n]2-, will be comprehensively evaluated using both in vitro 3D cell culture models and in vivo mimicking approaches, including 3D bioprinting.Overall, this project will allow me to carry out a 2-year project independently, growing towards a mature, professional, and independent researcher in the drug delivery field, reinforcing my expertise on advanced characterization of nanoparticle-cell interactions.


**Keywords:** Nanomedicine,  Hydrogel materials,  Therapeutic polymers,  Drug delivery,  Active targeting