RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'FUTURISTIC BEEHIVES FOR A SMART METROPOLIS' (HIVEOPOLIS).

assistant: **Innovation**

Honeybees are important pollinators and support various important ecosystems with their ecological services. Rapid anthropogenic changes cause disruptive disturbances of their habitats which are currently endangering honeybee colonies around the world and incurring an immense financial toll. We aim to help the bees in coping with these adverse environmental factors by establishing technologies in and around a futuristic honeybee colony that allow the colony to perform well in very challenging environments, for example within high-precision farming, including monocultural agriculture involving pesticide, within smart cities of the future and within highly industrialized areas. We aim to make technologies available to honeybees that are naturally inaccessible for them (internet, databases, satellite data, robots...) and to feed information collected by bees through these channels back to humans and other hives. This collection of hives, technologies and humans is called HIVEOPOLIS in our concept. HIVEOPOLIS technology will be integrated in a way that it provides a synergistic added value to the colony, to its owner and to society in general. It will be sustainable from the ecological point of view and also from the intellectual point of view (open software, open hardware, open data, citizen scientists). Our society will benefit from the pollination services and other bee-derived services and products, in a more stable and controllable way, even in harsher ecological conditions of the future. The emphasis on community-forming activities of the project will bring together makers, beekeepers, farmers, programmers, environmentalists, educators and many other stakeholders. Ultimately, HIVEOPOLIS will bring honeybee societies into a new future and will integrate them into the h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Supporting STakeholders for Adaptive, Resilient and Sustainable Water Management' under Horizon Europe.

assistant: **Concept**

Worldwide freshwater resources are under increasing pressures of rapidly intensifying climate change effects putting the availability and quality of water resources and socio-economic developments at risk. River basin organisations need to be prepared. STARS4Water aims at improving the understanding of climate change impacts on water resources availability and the vulnerabilities for ecosystems, society and economic sectors at river basin scale. STARS4Water will develop and deliver new data services and data-driven models for better supporting the decision making on planning on actions for adaptative, resilient and sustainable management of fresh water resources. The project team will work with seven river basin organisations through a co-creation, living lab approach. The new services and models will be co-designed with stakeholders to meet their needs on data and information, ensuring relevance and uptake for use beyond the lifetime of the project. The STARS4Water project includes two distinctive elements: first, the need for an international stakeholder community to address the stakeholders’ needs and requirements and second, the development and application of innovative data and model concepts. New datasets and models offer possibilities for improved projections on water resources availability, and the new insights on links between water, nature, society ask for a broader set of indicators to be considered in decision-making on water management. These novel datasets, models and indicators are not yet fully matured and integrated in current river basin management information tools and decision-making processes. We acknowledge that these elements are of a different nature, being a stakeholder-driven approach and rather science-(data-)driven in the application of novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Effects of Medication Use in Pregnancy on Infant Neurodevelopment' (DrugsInPregnancy).

assistant: **Concept**

Currently, thousands of pregnant women in the EU and worldwide are being increasingly prescribed medications for which we do not have sufficient information on fetal safety. I hypothesize that our current understanding of safety pharmacology is oversimplified and that medication prescribed during pregnancy may play an unrecognized role in the development of neurodevelopmental disorders.In this research proposal we have the unique opportunity to use a large population-based birth cohort including over 100 000 mother-child pairs and biological data to study how medications may act on the offspring. This offers novel and innovative pharmaceutical insight into the safety of medications.By linking several nationwide registries (National Prescription Data Base, Norwegian Patient Registry, Medical Birth Registry) to a population-based birth cohort (n=108 000) we specifically aim to 1) estimate the effect of prenatal exposure to psychotropics and analgesics on neurodevelopment in young children using a range of methodological approaches to strengthen causal inference.With these data made available, we will 2) determine whether fetal exposure to specific medications results in epigenetic events (i.e. changes in DNA methylation) in the child, and 3) determine whether such changes increase the risks of neurodevelopmental disorders in childhood.The recent availability of large scale human data, possibility of register linkages and genome-wide mapping of DNA methylation at affordable costs makes this research proposal now possible. The size and richness of data including over hundred thousand pregnancies and existence of biological material makes this project unique. The final outcome will be fundamentally new knowledge about how medications affect the developing unborn child and wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'AI-based wearable sensors for continuous monitoring of diabetes and cardiovascular diseases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Cardiovascular diseases (CVDs) are the leading cause of death in Europe, with a total of 3.9 million deaths yearly, accounting for 45% of all deaths. Diabetes is another widely spread disease affecting 60 million people in the EU (10% of the total population). Diabetes is the major cause of death in the age of 20-79. Also, Europe has the highest number of children with type-1 diabetes compared to other regions, with approximately 140,000 diagnosed children, and it has one of the highest prevalence rates of diabetes in children, with 21,600 new cases per year. Frequent glucose monitoring is critical for keeping blood glucose levels within a specific range to prevent potential cardiometabolic disease progression and pathophysiological changes. Current standard healthcare systems are passive and reactive, which deal with issues, incidents, and accidents after the opportunity to prevent damage to the patient has passed. With reactive healthcare, doctors provide treatment once patients contact them after developing noticeable symptoms. Actions are taken after things go wrong and sometimes after the opportunity to save the patient has passed. Besides, economically, reactive safety measures are costly in the long term. Moreover, this routine fails to prevent the onset of health conditions by prioritizing diagnostics and treatment. SensAI aims to tackle the limitations of centralized and reactive healthcare systems by taking a proactive approach using tailored, non-invasive, and personalized solutions (wearable monitoring devices) specifically developed for diabetes and CVDs without affecting peoples’ daily routines.


**Keywords:** Artificial intelligence,  Machine Learning,  Cardiovascular diseases monitoring,  Diabetes monitoring,  for cardiac and glucose monitoring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulatory mechanisms of wingless degradation' to be submitted under Fifth Framework.

assistant: **Abstract**

Wingless is a secreted glycoprotein that acts as a morphogen and plays fundamental roles in body patterning and cell differentiation. To prevent ectopic signaling, mechanisms have evolved that confine its range of action. One such mechanism has been discovered by the group that I am joining. In Drosophila embryos, the action of Wingless towards the posterior is limited by an EGFR -regulated pathway that targets this molecule for lysosomal degradation. My aim is to uncover the cell biological basis of this phenomenon. Using a genetic approach, I will identify the receptor(s) of Wingless that are responsible for its degradation. I will then study biochemically whether the receptor(s) undergo( es) post-translational modifications that might regulate the degradation process. The receptors will also be mutagenised in vitro and their ability to mediate degradation assayed. Together, these two approaches will allow me to map the sites, within the cytoplasmic tail of those receptors, that are required for regulated lysosomal targeting. In parallel I will identify additional proteins that regulate the degradation process. This will be done in two different ways:1 ) using RNA-i to test the role of candidate molecules and2) isolating biochemically proteins that interact with the receptor only at the stage when the degradation process is activated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NEOlithic MEDiterranean diet through stable ISotope analysis' (NEOMEDIS).

assistant: **Concept**

The introduction of farming (6th millennium BC) fundamentally transformed the Western Mediterranean but prehistorians have long argued about the causes, tempo and completeness for this change. Stable isotope analysis (SIA) of ancient human bones provides a novel approach for addressing this problem directly reconstructing diet and crudely assessing the transition from foraging and fishing to farming. However, there are some uncertainties with this approach precluding the accurate determination of the extent to which Neolithic ‘farmers’ still relied on marine foods. This is important as a prominent model for the so-called ‘Neolithisation’ is of population replacement and of a complete change to domesticated cereals and animal products. The existing state-of-the-art relies on analysing bone protein from skeletal remains and relate these measurements to data obtained from potential food sources. NEOMEDIS aims to advance this approach by breaking down the protein into their constituent amino acids and analysing the carbon, nitrogen and sulfur isotopes in these individual molecules tracing different dietary components to obtain an approach that will provide a more accurate dietary reconstruction. NEOMEDIS will provide detailed dietary reconstructions for 75 Neolithic individuals from the NW Mediterranean dating from the first arrival of farming to the Middle Neolithic to examine the change over this period. Skeletal remains from key sites are already in hand, benefit from excellent chronologies and contextual information provided by leading expert collaborators in Spain, France and Italy. The fellowship will furnish the applicant in next-generation methods skills in SIA that are beginning to be widely applied in ecology, archaeology and geochemistry using facilities that are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular and cellular bases of heart regeneration in the zebrafish' (REGENZEBRA).

assistant: **Innovation**

Regeneration is a complex biological process by which animals restore the shape, structure, and function of body parts lost to injury or experimentally amputated. Only a few vertebrate species retain a significant regenerative capacity during adulthood. With respect to the heart, the extraordinary ability of newts to regenerate significant sections of the heart has been known for over 30 years.However, the molecular and cellular mechanisms underlying this phenomenon remain largely unexplored, most probably owing to the intrinsic experimental difficulties and relative lack of genetic tools in this model system. Recently, it has been shown that adult zebrafish also display a remarkable ability to regenerate extensive portions of the heart after amputation.In this project, we propose to take advantage of the powerful tools of genetic manipulation, genomic analysis, in vivo imaging, and reverse-genetics mutagenesis screenings available in the zebrafish, to undertake the following specific aims:1) to identify and characterize the molecular mechanisms associated with the regenerative response of the zebrafish heart;2) to characterize the changes in cell behavior dynamics associated with zebrafish heart regeneration;3) to identify novel genes required for regeneration in the zebrafish.We feel confident that detailed analyses of zebrafish heart regeneration, such as the one proposed herein, in addition to bolstering our understanding of this fascinating biological phenomenon, will provide valuable clues for the implementation of strategies of regenerative medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Over-The-Counter Test Strip for Early-Stage Cancer Screening' (BiomStrip), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is the second leading cause of death globally, causing 1 in 6 deaths. If cancer is diagnosed at early stage, it is highly likely to be treated successfully. Once it has grown and spread, therapy is vastly more difficult and costly, and survival rate drops rapidly. Screening is a vital healthcare element for early detection but suffers from burdens of cost, capacity, compliance, and detection sensitivity problems.BiomStrip introduces a pioneering screening solution that can carry out cancer screening in the fashion of the common pregnancy tests. Building on our recent breakthrough results in biomarker validation granting TRL6 stage, we have designed a diagnostic device that is low-cost, non-invasive, accurate, can be handled by consumer, and bought over-the counter. The diagnostic method is based on detecting dysbiosis of gut microbial flora, a highly sensitive indicator of pathophysiological processes able to selectively show disease onset at super-early stage, even before histological changes are observable. The method is ultimately able to detect most cancer types and even other diseases, making it a future platform technology.For highest scalability, fastest time-to-market, explosive growth, low resource-intensity, and minimised risk and overheads, we will license production and commercialisation to established multinational companies, keeping our focus as high-tech SME. Breast cancer will be our market entry point and other diseases will be covered subsequently form own resources.To engineer this Workplan, a feasibility study will assess entry use cases and their markets, analyse business model and partnership options, and evaluate IPR strategies in a Strategic Business Plan.The disruptive approach offers to transform cancer screening from top-down to bottom-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Disfluencies and Eye MOvements during Speech: what can they reveal about language production?' under Horizon 2020.

assistant: **Concept**

Speech production is full of disfluencies, which are “phenomena that interrupt the flow of speech and do not add propositional content to an utterance”. However, it is not well understood why speakers are so often disfluent. To reveal the underlying causes of disfluency, most approaches attempt to relate the pattern of disfluencies to difficulties at specific levels of language production. The current project will also investigate disfluency by manipulating different levels of production. In addition, we will bring together different accounts of disfluency by 1) capturing monitoring or stalling strategy using eye-tracking and 2) identifying the role of non-linguistic cognitive functions and individual differences through neuropsychological tests. Findings will open new avenues for the investigation and understanding of discourse production, in normal and in clinical populations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Evolutionary Mechanisms in the Milky waY: the Gaia Data Release 3 revolution'.

assistant: **Concept**

The understanding of our home Galaxy stands at a crossroads. Thanks to the Gaia mission of the European Space Agency, combined with ground-based surveys, previously unexplored portions of the Milky Way have recently been mapped, opening a new era in Galactic Astronomy and Astrophysics. In 2022, Gaia Data Release 3 will publish the largest chemical and radial velocity stellar catalog ever created. For the first time, chemical abundances of stellar atmospheres will be linked to the positions and motions of stars over the entire sky. Taking advantage of the unprecedented wealth of chemo-dynamical data, the EMMY project aims to tackle outstanding questions about the mutual interplay of different evolutionary mechanisms in the Galactic disc, including the influence of the Milky Ways satellite galaxies, along with secular evolutionary processes. Specifically, the EMMY project aims to: 1) map chemo-dynamical inhomogeneities in the Galactic disc; 2) determine the extent to which the observed inhomogeneities can be attributed to internal processes, such as the actions of the spiral arms or the bar; 3) constrain the role of external influences, such as satellite interactions, on the disc evolution. The objectives will be assessed through an optimised Galactic cartography, which will link inhomogeneities in stellar density, velocity, chemistry; observational results will be then compared to cosmological simulations and chemical evolution models, to constrain spiral arms formation scenarios and disc heating processes. The multidisciplinary nature of the project is strong, combining interdisciplinary knowledge of astronomy, physics, statistics, data mining, and big data analysis. The results of the proposed project are expected to give a cohesive, statistically robust, accurate, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Professionals and Parenthood in the Twenty-first Century' (IDPSF) targeting Seventh Framework.

assistant: **Abstract**

This project aims to contribute to a better understanding of work-life conflict and the negotiation of parenthood in professional service firms (PSFs) from a cross-national comparative perspective (France, Romania and the UK). These countries provide very different cultural and institutional settings and as work and parenting norms are culturally and institutionally shaped, conducting cross-national research will allow a more nuanced understanding of the complex interactions between the two. PSFs provide particularly rich settings to study work-life conflict due to the long working hours and client availability requirements. As knowledge-intensive firms, the value of PSFs is based primarily on their professional workers. Developing and keeping their human resources is therefore fundamentally important to PSFs in terms of competitiveness, productivity, professional integrity and reputation.In-depth interviews will be used to examine how professional identities and parenthood are embedded within organizational policies and practices shaped by national contexts.This research is innovative as it takes a holistic view of parenting and work-life conflict by adopting a multilevel approach and by focusing on parenthood rather than motherhood. This project is very timely as it addresses directly two key issues currently on the agenda of the EU and its member states: (1) the matter of gender diversity in economic leadership positions; and (2) the impact of parental leave on professionals’ careers, as well as reinsertion upon return. In addition, my project is highly relevant to the ERA as: (1) it is interdisciplinary, (2) it provides me with excellent training and international collaborations which will significantly advance my future career. Against the backdrop of globalization