RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Numerical modelling of reinforced slender wooden window elements' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Oversized window systems with extreme heights are becoming increasingly popular at European and global market. Such sizes can cause problems of bending of slender wooden elements which results in the decrease of main windows properties, quality and functionality. Project XtremelY (Numerical modelling of reinforced slender wooden window elements) will lead to a development of parametric numerical model of reinforced slender wooden window elements, which will lead to future development and production of oversized openable window systems with extreme height (Y). Main goal of XtremelY project is to develop numerical models of reinforced wooden window profiles which will allow the production of window systems with height of over 4 m which means 60 % higher products compared to standard ones. Window profiles will have improved stiffness (compared to wooden beam) for 50 %, improved load bearing capacity for 50 % and thermal conductivity lower than 1.0 W/m2K. The development of numerical model/s of reinforced slender wooden window elements will represent an innovative approach at global scale in wooden window industry and a digitalisation of wooden window profiles. Such approach is a basis for future high-tech solutions in wooden window industry and smart homes. Numerical models will also be a basis for new development approach which will be much quicker, precise and cost effective.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Epilepsy Pharmacogenomics: delivering biomarkers for clinical use' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The purpose of the project is to identify genome-based biomarkers for use in clinical practice to individualise treatment of epilepsy, and stratify patients for clinical trials, aiming to avoid chronicity, prevent relapse and reduce adverse drug reactions (ADRs).The need for improved treatments in epilepsy is undoubted. Epilepsy is affects 50,000,000 people of all ages worldwide. Epilepsy is serious, increasing morbidity across all aspects of life, including a high risk of premature mortality. Over 20 antiepileptic drugs (AEDs) are licenced for its treatment. Seizures can be effectively controlled by AEDs in ~70% of people. Control of seizures leads to risk reduction for most of consequences of epilepsy, improves quality of life, permits social re-integration and leads to direct economic benefits. However, in 30% of patients, currently-available AEDs do not control seizures – recurrent seizures threaten life and impair its quality in these patients, and account for much of the €15.5 billion annual cost of epilepsy in the EU alone; there is currently no way to predict which patients will not respond to any or all AEDs; even in the 70% who do respond, only 47% respond to the first AED – whilst the correct drug is being sought, risks from seizures continue – we need to be able to predict the right drug for an individual from the outset; unrelated to responder status, AEDs can cause serious ADRs – a biomarker exists for only one ADR; there is a clear need for novel means of discovery of new AEDs – existing AEDs are anti-seizure drugs, not disease-modifying drugs.We will use genome-wide analyses, including next-generation sequencing, in large, well-phenotyped patient cohorts to identify genome-based biomarkers, to improve use of current AEDs and identify new therapy targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Source control of priority substances in Europe' in the context of a Sixth Framework call.

assistant: **Objectives**

With the new regulations included in the Water Framework Directive (WFD) (2000/60/EC), new strategies are needed for control of Priority pollutants (PP). For decision-making and implementation of the WFD, the industrial sector, local water authorities and EU policy makers need guidelines for the selection and introduction of feasible and cost-effective measures. The overall objective of this project is to support the implementation process for the WFD by providing guidelines and decision support tools f or the management of priority pollutants.To fulfil this overall objective the following activities are proposed:- To conduct a material flow analysis for selected priority pollutants.- To evaluate available and emerging measures and management options for PPs.- To develop a decision support tool for identification and selection of relevant measures on European, national and regional level.- To evaluate different potential measures by applying the decision support tools in case studies.- To facilitate the development of collective action plans (i.e. river basin management plans) involving all stakeholders (industries, authorities, citizens, NGOs).- To disseminate results to stakeholders and to strongly interact with industrial organisation s, research networks, authorities and NGOs.A Stakeholder Advisory Group (SAG) will be formed with representatives from industries, authorities and NGOs. The SAG will be consulted during all steps in the process of collecting information, developing the decision support tool and the suggested set of management measures. The cooperation with the industrial sector, the different authorities and other stakeholders (public, NGOs) will ensure the accuracy and relevance of basic data collection, as well as the applicability, acceptance and rel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Demonstrating the utility of sar differential interferometry for the assessment of seismic risk'.

assistant: **Concept**

The primary objective is to demonstrate the utility of ERS SAR differential interferometry for the assessment of earthquake risk in Greece. Secondary objectives are to integrate the infommation from interferometry with other new and existing infommation to demonstrate a) a Seismic Risk GIS for Greece and b) a Seismic Risk Web-Site for end-users. Earthquakes are a major hazard and world-wide there are on average 1,000 deaths per year. In Greece, the cost of damage exceeded 1.2 billion USD in 1995. Assessment of seismic hazard is complex and more accurate spatial and temporal prediction is needed. The proposed partnership has demonstrated the technical feasibility of interferometry to map displacements associated with earthquakes and seen how beneficial use might be made of results. It is therefore timely to fully assess the utility of difSAR to those responsible for earthquake risk assessment - this is the primary objective of the proposal. To meet the objective, the work proposed must a), apply the technique over regions at risk and b), demonstrate the benefits of the results. Test-sites in seismically-active regions of Greece have been selected for analysis using both archive and newly acquired ERS data. These areas experience secular tectonic displacement as measured by a variety of geodetic survey techniques and have ground cover suitable to the demands of interferometry. To aid the demonstration and test for the replacement of some ground-based monitoring networks by difSAR, radar comer reflectors will be used to validate movement and strain estimates. Transfommed and integrated with other infommation, results will be used to demonstrate the utility of a Seismic Risk GIS for use by the Customer in their day to day work of monitoring and remediation planning. Derivat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Diapause-mediated cattle embryo storage' under Horizon Europe.

assistant: **Concept**

Embryo transfer is a key enabling technology in the farming industry, playing an essential role in expanding genetic improvement and its associated economic and environmental benefits. The procedure requires estrous synchronized recipient animals, which are often not available at the same time and location than the embryos. The only solution available to circumvent this problem is to arrest embryo development by cryopreservation, a technique that allows embryo storage but reduces embryo viability and requires time, training and specialized equipment. Diapause is the natural way to temporarily arrest embryo development and it could provide an alternative means to store embryos before transfer. In this project we will employ an advanced embryo culture system developed by the project StG-757886-ELONGAN -able to sustain embryo development beyond blastocyst hatching- as a platform to test different media modifications to induce diapause in bovine embryos. The development of a diapause-inducing medium will constitute a better solution than cryopreservation, as it avoids the mechanical damage and exposure to cryoprotectants, circumvents the need of special equipment, and provides a faster and easier to learn protocol to store embryos.


**Keywords:** Embryo, diapause, ungulate, farm animal, embryo transfer, bovine, developmental biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Unique Virtual Environment where Healthcare Professionals Can Find the Support that They Need for an Adequate Use of Pharmaceutical Products' to be submitted under Horizon 2020.

assistant: **Abstract**

For pharmaceutical products to work effectively, they need to be used properly. In Europe, 50% of patients fail to adhere to the prescribed regime, incurring in € 125 billion costs. Poor patient adherence is often the result of poor management at the practice level. Indeed, the correct use of pharma products begins with the prescription by doctors and proper guidance from pharmacists. Therefore, it is important that pharma companies provide these professionals with the education they need, anywhere and anytime. Pharma companies have traditionally relied on sales representatives and agents that pay visits to healthcare professionals. However, this method is time consuming, costly, extremely inefficient and difficult to schedule with the busy healthcare professionals. Importantly, professionals lack the means to communicate back with the pharma company. Despite this acknowledged inefficiency, agents are still the best alternative available right now in the market. In response, we have created DOCTRINA, a unique and cost-effective ICT platform through which pharma companies will be able to maintain 24/7 communication with healthcare professionals to provide them customized educational materials. While learners experience barrier-free communication and support, pharma companies improve their businesses and product management. Since our preliminary version of the platform received high acceptance from end-users, we now aim to take the next step and scale up our model to hold a global community of users. Thus, the Feasibility Study planned in Phase 1 has the main objective of securing this project from all technical, commercial and financial perspectives. Altogether, our platform will bridge the existing gap between pharma providers and care givers, helping to relieve the hug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Aquatic chemistry and thermodynamics of actinides and fission products relevant to nuclear waste disposal' (ACTAF).

assistant: **Innovation**

The project aims to improve the scientific basis for the assessment of performance and safety in waste management. It will provide fundamental knowledge about the behaviour of actinides and fission products in natural aquatic systems.The project focuses on key areas where further research is essential, including:i) understanding of the mechanisms that govern the interaction of actinides and fission products in natural aquatic systems;ii) closing existing gaps in the available thermodynamic database; andiii) reducing uncertainities in currently used constants. Investigations focus on the thermodynamics of aquatic actinide ions, particularly in the tetravalent oxidation state, on the interaction of actinides and fission products at the solid/aqueous solution interface and on the thermodynamics of secondary solid phases. A link will established to theoretical methods for prediction of chemical behaviour in actinide systems.A notable breakthrough has been achieved filling serious gaps in the database for tetravalent actinides, necessary e.g. to predict the geochemical of plutonium. The understanding of actinide complexation with small organic ligands, which may serve as model compound for natural organic matter, has been substantially increased using various spectroscopic methods and theoretical approaches. Computational methods (molecular modelling) have been applied for the first time to chemical problems related to nuclear waste disposal.An improved understanding of actinides interaction at the mineral/groundwater interface and sound sorption data have been provided. Mechanistic insight into the sorption of U(VI) on iron oxides including surface enhanced redox reactions has been achieved as well as the elucidation of the speciation of trivalent actinides sorbed onto alum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mobility justice for all: framing safer, healthier and happier streets' (2021-2027).

assistant: **Concept**

JUST STREETS is the project proposal from a team of 30 partners from 17 countries, including 12 cities representing more than 4,5m citizens. It aims to transform cities’ car-centered mobility narratives that take for granted that streets are for motorized traffic only, promoting walking, cycling and other active modes of mobility. JUST STREETS will be re-shaping street infrastructure and changing individual mobility behavior in 12 cities, while proactively sharing the generated “how-to-do-it” knowledge with hundreds of cities for rapid replication across Europe. In close collaboration with citizens, policy makers, experts, and interest groups the project will not only develop a new vision of spatial justice where streets become public space for all, but equally important find ways to rapidly implement changes. A strong focus is on displaying how necessary transformations in the face of climate change can (and must) successfully improve social justice, accessibility, inclusivity, and security along the way. Putting marginalized social groups, the most vulnerable mobility users, as well as those citizens at the core of JUST STREETS that have been previously underrepresented in mobility infrastructure decision-making will allow the project to create highly valuable knowhow, critical in creating better, more just, and sustainable cities for all citizens.The unique composition of the JUST STREET consortium is critical in making sure this knowledge is not only created, but subsequently shared with as many urban decision makers as possible from cities across Europe who have the means to initiate transformation in their cities. Top-level research and organizations with vast experience in the fields of mobility, urban planning, climate change, and social transformation are colla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'VERY INNOVATIVE AIDS VACCINE' (VIAV) targeting Sixth Framework.

assistant: **Abstract**

The aim of VIAV is to develop a highly innovative Env-based vaccine capable of inducing cross-clade neutralizing antibodies to prevent HIV infection.This represents the most important problem of current Env-based vaccines.VIAV aim will be achieved through new antigen design stemming out from novel virological, immunological and modeling data of the VIAV Consortium indicating that Tat increases HIV cell adsorption, infectivity and tropisms via a molecular mimicry of the CCR5 co-receptor.In fact,Tat binds the V3 loop of the HIV Env at the same residues binding the CCR5,allowing the generation and stabilization of complexes presenting cryptic and/or transiently exposed Env epitopes.These are crucial for inducing cross-clade neutralizing antibodies. In addition , R5 viruses are the major virus phenotype transmitted to healthy individuals.The goal of VIAV will be fulfilled through the achievement of specific objectives which, in turn, are the focus of specific workpackages: 1.Characterization of the Tat/V3loop com plex through the combined application of bioinformatics tools, NMR studies and microcalorimetry measurements 2.Generation,chemical-physical,immunological and biological characterization of Tat/Env complexes and their formulation for in vitro and in vivo s tudies 3.Evaluation of the safety and immunogenicity of different Tat/Env complex-based vaccine formulations in small animal models 4.Characterization of the specificity of the antibody responses generated in immunized animals 5.Characterization of virus-s pecific and cross-clade neutralizing activity of antibodies generated in immunized animals. The achievement of VIAV objectives will be implemented through a rigorous management of the scientific, business and administrative activities by the Steering Commi ttee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigating the commercial feasibility of a novel biological enhancement technology for creating a sustainable, high value, insect-derived protein supplement for the EU aquaculture market' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The FAO estimates that to we need to produce 70% more food by 2050 to sustain the world’s growing population.Aquaculture is a promising source of nutrition and food security due to relatively low resource requirements, accessibility for operators in the developing world and an increasing global demand for quality protein. During the last three decades, world aquaculture production increased from 5 million to 63 million tons, and represents an increasingly large component of human protein consumption.However, intensive aquaculture of carnivorous fish species – like salmon and trout – requires large inputs of unsustainable feed ingredients like fishmeal from wild-caught forage fish as far away as Chile, due to its high protein and oil content. Thus, feed costs can comprise up to 75% of an aquaculture operation’s overall cost in the EU. In addition, intensive aquaculture continues to be plagued by the incidence of disease and lice infestation – exacerbated by stressful conditions such as overstocking and poor water quality, and requiring the industry to respond with harmful antibiotic and chemical interventions.Entomics’ innovative technology enables the production of novel insect-derived protein feed that is sustainably grown from waste substrates at low cost, and presents a viable substitute for fishmeal given similar protein and omega-3 oil profiles. More importantly, our patent-pending processing technology enhances this protein feed with key biological characteristics that promote enhanced growth and overall fish health. We currently produce this feed in a Pilot facility, and are conducting fish feeding trials to test efficacy in different species.The purpose of this study is to investigate the commercial feasibility and technical scalability of our novel processing t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mental health disability : a european assessment in the year 2000', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Data on disability burden of mental disorders in Europe are incomplete and lack comparability. The project will :a) estimate the prevalence and risk factors of mental disorders,b) assess their impact on disability and handicap andc) evaluate the utilisation of mental health services in 4 European countries. Representative samples (n=6000 per country) will be assessed with standardised, cross-culturally appropriate instruments. Co-ordinated analyses and rigorous quality control will ensure validity and comparability of results. Informative differences in prevalence rates and associated risk factors of mental disorders are expected. After adjustment, sizeable differences between countries in utilisation patterns of mental health services and level of unmet need for care are expected. After dissemination to relevant audiences in Europe, results will improve monitoring of mental health reforms and provide new research hypotheses.