RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The map of Redox Intracellular Signaling in skin physiology' to be submitted under Horizon Europe.

assistant: **Abstract**

The skin is the widest organ of the human body. Despite this, the mechanisms that underline its regulation are relatively poorly understood. Many skin diseases are characterized by defects in the control of lining renewal or reestablishing barrier integrity after the disruption. Thus, dissecting the signals that underpin the maintenance of skin homeostasis and regeneration are of pivotal interest for medicine. Recently, redox signaling as described to have a crucial role in these processes: indeed, H2O2 -the major signaling molecule of redox biology- is not only an essential second messenger, involved in skin proliferative and survival pathways but also it is reported that mild ER stress cursing with an increase in organelle redox potential is needed for efficient reepithelization. Recently, we have shown the presence of different ER-linked H2O2 fluxes that orchestrate cellular redox responses in normal conditions and after the induction of ER stress in HeLa cell lines. In this scenario, I propose to unveil the compartment-specific H2O2 fluxes that regulate the redoxstasis during keratinocytes differentiation with particular emphasis on those that arrive from the Endoplasmic Reticulum (ER). Indeed, the ER is one of the major contributors to cellular redoxstasis harboring sources, internal regulators, and distributors that vehicle redox signals back and forth to the ER. In particular, I divide this project into two main aims I) Characterize the role of intracellular redox fluxes during keratinocytes differentiation both in 2D and in 3D models II) Identify the interactors of ER-derived H2O2 flux in skin cell lines and characterize the downstream pathways. Importantly, a systematic analysis of the timing, thresholds, and targets of redox signals in skin pathways is a param
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New Technology for Cascade Combinatorial Chemistry' to be submitted under Fourth Framework.

assistant: **Abstract**

This project is aimed at establishing advanced generic technology for the University output of combinatorial chemists in essentially zero. The network will remedy this and provide researchers with a broad advanced synthesis of complex heterocycles based on cascade combinatorial chemistry. skill base in key technologies by ensuring multiskill acquisition in The targeted core heterocycles include a number of outstandingly valuable agrochemicals and drugs, so there are major opportunities for this generic multicomponent cascade combinatorial chemistry, catalysis, computational techniques (diversity, virtual libraries), analytical techniques, polymers technology to lead to new, more effective, agrochemicals and medicines synthesis/fabrication. There is no skill base in the agro/pharma industries thereby benefiting both European industry and quality of life. in cascade combinatorial chemistry and polymer synthesis/fabrication. All The project platform is the innovative skill base of the partners which places them at the leading edge in catalytic (Pd/Ni) cascade reactions and researchers will gain (i) experience at two academic laboratories and cascade cycloaddition reactions supported by a major agrochemical company Rhone-Poulenc (ii) high quality skills in cascade combinatorial chemistry (Rhone- Poulenc) and two interdisciplinary research centres, in Polymer and associated technologies (polymers/analytical) (iii) verbal and written presentational and problem solving skills via network seminars and work-Science and Molecular Innovation, Diversity and Automated Synthesis (MIDAS). shops. Using a clean technology multicomponent cascade reaction approach provides a major breakthough that enables a combination of complexity and diversity to be achieved that far outstrips that ava
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CircularPSP – Public Service Platforms for Circular, Innovative and Resilient Municipalities through PCP' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

CircularPSP brings together 7 procurers from 7 countries, representing 45 million citizens, to invest €5.64 million in R&D to tackle the common challenge of accelerating digital transition towards a Circular Economy (CE). The Buyers Group represents highly attractive national markets (DE, FI, TR, SE, IE, PT, SI) supported by a Preferred Partner in UK, including capitals with global influence (Berlin, Helsinki, London, Istanbul). The consortium represents European CE-transition and PCP leaders in science and practice.Suppliers are expected to deliver a new green digital public service and data platform enabling entire municipal operations (city) and the local economy (market) to choose, open up, and consume existing and new data. The solution is to support business processes and workflows to plan, procure and implement innovative CE-solutions across Europe more quickly and at larger volume. The unmet procurement needs are: tools to improve organisational and operational performance; data analytics using taxonomies to exploit and exchange CE information and data; removal of language barrier to unlock EU-wide knowledge and learnings. To enable the transition suppliers will answer with ICT innovation in the cross-cutting combination and leveraging of existing and new strategic digital technologies: 1) scalable platforms for city and SMEs users, 2) CE data analytics using EU taxonomy, open linked data, injected by AI, and 3) natural language processing (NLP) to break language barriers across the EU and beyond.The envisaged solution is relevant for all European authorities including cities, ministries, agencies, and housing. Activity triggered by the solution will increase the volume of circular procurement and widen commercialisation opportunities for green digital companies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Gene networks controlling embryonic polarity, regulation and twinning'.

assistant: **Innovation**

Much of what we know about how embryos determine their axes of symmetry comes from research in invertebrates (mainly Drosophila) and cold-blooded vertebrates (mainly Xenopus). In both cases, polarity is set up by the localisation of maternal determinants in the cytoplasm of the fertilised egg. These determinants are inherited differentially by daughter cells, leading them to acquire different fates, which effectively fixes the axes of the embryo by the 8 cell stage. In contrast, in amniotes (reptiles, birds and mammals) embryonic polarity remains plastic until much later, just before gastrulation, when the embryo may contain as many as 50,000 cells. If an embryo at this stage is cut into fragments, each fragment can generate a complete embryo. This property, called embryonic regulation", is thought to be responsible for the generation of monozygotic (identical) and conjoined ( Siamese ) twins in humans and other amniotes. We know almost nothing about how polarity is determined in higher vertebrates or about the mechanisms of embryonic regulation and twinning. This project uses a multi-disciplinary systems approach to reveal the gene interaction network controlling polarity, regulation and twinning. The project will also generate a mathematical model of early development or "virtual embryo", allowing prediction of experimental outcomes and clinical scenarios."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nuclear spectroscopy with radioactive beams' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content In this project the nuclear structure physics of the neutron deficient N = Z nuclei in the A 70-80 region will become subject of detailed gamma-ray spectroscopy, in some cases for the first time. The richness of different nuclear structure information which can be found in this mass region is important for the progress of experimental nuclear physics and a great challenge for their theoretical interpretation. Since the nuclei of interest can presently only be populated with extremely low cross-sections (or not at all) the use of radioactive beams is a necessary prerequisite for an increased production rate, which in some cases will lead to the first ever access to these nuclei. These studies will be realised with the gamma-ray spectroscopy group of the DAPNIA/SPhN at CEA Saclay. This group has a well known experience in gamma-ray spectroscopy and is presently preparing for nuclear structure studies using the radioactive beams from the 'Systeme de Production d' ions Radioactifs et d'Acceleration en Ligne (SPIRAL) facility at GANIL (Caen, France). Currently a new highly effcient and highly segmented gamma-e, spectrometer for nuclear spectroscopy (EXOGAM) is under development. Working with EXOGAM at SPIRAL wil give a unique possibility to work with the most recent detector technology and extend my earlier experience with (composite) germanium detectors of the first generation. Training content Nuclear Structure studies with the new generation of segmented germanium detectors. Experience with the new technology of radioactive beams Expertise in different experimental methods, such as Coulomb excitation and transfer reactions The basic knowledge of nuclear structure physics will be significantly extended Links with industry / industrial releva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Evaluation of computational fluid dynamic methods for reactor safety analysis' to be submitted under Fifth Framework.

assistant: **Abstract**

The capabilities of the current Computational Fluid Dynamic (CFD) codes in relation to safety analysis of existing installations and evolutionary reactors will be assessed in the present project. Through a comprehensive evaluation of previous applications for both primary loop and containment analysis, recommendations on their use will be made and perspective application areas will be identified.A consensus will be achieved on the code extensions that are needed for comprehensive simulations of a range of safety-relevant accident scenarios to prepare the technical basis for coordinated research projects in future. It includes a new validation exercise of basic capabilities of the codes in relation to containment analysis and severe AM. This is to improve understanding of merits and limitations of CFD and defining realistic goals of these methods in safety analysis and reinforcing network among CoC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Co-creating inclusive local climate adaptation practices to deal with experienced heat', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

European societies, especially in urban areas, are disproportionately affected by the impact of global warming. Global warming can be felt by how people experience heat at home - which is often a combination of the temperature and air humidity in their residence. Experienced heat and heat stress may vary across people’s houses, also depending on the adaptation strategies they apply and affect people’s health outcomes and experiences. Migrant populations, ranging from migrants to their descendants, are often excluded from current data collection and measures, creating environmental injustice, and in turn strengthening social and ethnic inequalities in societies. The HARARA project aims to contribute to the EU Mission on Adaptation to Climate Change by supporting regions such as Belgium and the Netherlands, and more specifically, their cities and local authorities, to become more resilient in the face of climate change impacts. HARARA will systematically integrate insights from multiple disciplines (sociology, ecology, biology, urban planning, etc.), as well as societal and educational institutions, to first empirically assess both subjective and objective climate impacts on migrant groups. Afterwards, a citizen science approach will be taken to empower local migrant communities to actively participate in and contribute to inclusive climate policies of the future through the development of inclusive climate adaptation practices. The inclusive climate adaptation practices will be included in the EC Mission Portal; triangulated with stakeholders, presented in policy briefs and a Toolkit for schools, two sustainable and inclusive fairs, and reports for non-academic audiences. Furthermore, HARARA sets up transdisciplinary knowledge hubs, supported by integration specialists o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'VASCULAR BONE' in the context of a Seventh Framework call.

assistant: **Objectives**

AbstractThe European population is ageing, forecasting a growing demand of health care solutions. The demand for biomaterials, either for orthopaedics, dental or maxilla-facial applications, will follow this trend. According to Biomet report, it is estimated that in Europe, 180,000 man and 610,000 women will suffer from hip fracture due to osteoporosis. These numbers will grow until 2050. Bearing in mind European population ageing as well as the status of social and financial indicators, it is urgent to develop more successful bone substitutes. A large number of bone substitutes made of calcium phosphate-based materials are commercially available. Despite the progresses that have been made with regard to their biocompatibility, one research area is being serious neglected: the study of the capability of acquiring blood vessels (angiogenic capability). The presence of blood vessels is the first critical step of bone regeneration and affects the implant success rate. The present proposal aims to tackle this problem through the development of a bone substitute with angiogenic potential, the VASCULAR BONE.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanism-guided in vitro evolution' to be submitted under Fifth Framework.

assistant: **Abstract**

Using a directed evolution approach, the activities of two structurally similar enzymes, alkaline phosphates and arylsulfatase, will be evolved into each other. The detailed mechanistic characterisation of the new enzymes will address questions about the initial stages of an evolutionary process and the nature of catalysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Liquid Biopsy blood test in lung cancer diagnosis and monitoring: a next generation noninvasive tumor tracker device' under Horizon 2020.

assistant: **Concept**

The ultimate objective of the Celletest project is to develop a next generation medical device for non-invasive diagnosis and prognosis of metastatic lung cancer, so we can validate the . To achieve this ambitious objective, we will exploit the potential of our proprietary technology for isolation of circulating tumor cells from the bloodstream, so we can validate the clinical utility of CTCs, which have been already identified as biomarkers for the liquid-biopsy of metastatic lung cancers. What is a Liquid Biopsy? Liquid biopsy is an emerging and disruptive technology in cancer diagnosis, prognosis and monitoring of evolution of cancer patients under anticancer therapies. This novel technology can be understood as the next generation non-invasive alternative to the current gold standard in cancer diagnosis, tissue biopsy. Tissue biopsy implies an interventional/surgical procedure to sample cells or tissue at the tumor site. The biopsied tissue is examined and analyzed (molecular characterization for the determination of the molecular biomarkers of cancer cells) in order to characterize the cancer cells according to their morphological and biochemical properties. This allows determining the tumor typology and prescribing the most optimal anticancer therapy. Liquid biopsy holds promise as a non-invasive method capable to obtain the same clinically relevant information with just a simple blood extraction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Open and scaleable intelligent metering system chipset'.

assistant: **Concept**

The project is aimed at the development of a chipset that will consist of three devices:The PLC ModemThis modem chip formats data sent or received via the power line. The modulation type is Spread-Frequency Shift Key in the 50 kHz to 100 kHz frequency band, with a baud rate of 1200 baud. The protocol will be handled via an external microprocessor. Frame synchronisation, deframing and error correction will be done internally by embedded logic. It will comply with the Cenelec standards EN 500651.The Metering Device InterfaceWill provide the electrical interface with the electricity, gas, water and heat meters within the cost constraints. It has to fulfil the major standards IEC 1107, IEC 1142 and DIN 43.864 or 50 interface. The circuit should also contain the necessary driver, signal conditioning circuitry and protection against disturbances.The Driver CircuitWill provide the high driving current (250 mA) and signal conditioning of the output and input signals such as amplitude limiting and AGC for the input signals.The chipset developed in the OSIM chipset project will provide a cost effective way of implementing communication between the electricity utilities and their customers. This project will run in close cooperation with the OSIM AHSII project that treats the development of equipment for the communication gateway. The project includes the development of three integrated circuits namely the Power Line Carrier Modem, the line driver and a generalised interface to a metering device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ENTANGLED FREEDOMS: Decolonial Modernisms as Transnational Relations of Resistance, 1940s-1980s' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ENTANGLEDFREEDOMS studies how practices and discourses of artistic modernism from the decolonizing worlds of Asia, Africa, and the Middle East entangled with plural and contesting notions of freedom during 20th-century decolonization and Cold War. Taking scopes of ‘freedom’ out of hegemonic Cold War binaries of western ‘First World’ vs. socialist ‘Second World’ values, I read it instead, in dialogue with its resonant global vocabularies of independence/liberation/emancipation, and via visual art. I argue that during Cold War decades of 1940s-1980s, decolonial modernisms from ‘Third World’ contexts of Asia, Africa, and the Middle East – with their visions of freedom as anti-colonial independence and liberation movements – both engaged with and resisted ‘First World’ notions of freedom as universalist individualism and socialist ‘Second World’ notions of freedoms as revolutionary struggle. Drawing from the Caribbean theorist Édouard Glissant, I call these ‘relations’ of resistance, whereby decolonial modernisms relate with First/Second World ideas of freedom via difference – not in unilinear assimilation or resistance, or in pure refusals via ‘non-alignment’. In ENTANGLEDFREEDOMS, I lead a Project Team to answer collectively a research question not yet asked in the expanding fields of global (art) histories, postcolonial studies or even 21st-century decolonial theories: How did 20th-century decolonial modernisms visualize, entangle, and transform plural visions of freedoms across and beyond geographies of Cold War and decolonization? With its empirically rooted historical and relational methods, and a theoretically generative research plan for comparative decolonial aesthetics from Asia, Africa, and the Middle East – in relation with Euro-American histories – ENTANGLEDFRE