RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Children and Adolescents with PaRental mental Illness: Understanding the ‘who’ and ‘how’ of targeting interventions'.

assistant: **Concept**

At least 10% of mothers and 5% of fathers have a mental illness. Family, educational and social lives of children and adolescents with parental mental illness (CAPRI) are disrupted by deprivation and repeated hospitalisation. This is an urgent political and public health concern. The Child and Adolescent Mental Health in Europe (CAMHEE) report urges us ‘to acknowledge and attend to the needs of children and families with parental mental health.. ’ recommending better information on CAPRI risks and resilience so interventions can target those at highest risk. This groundbreaking interdisciplinary programme exploits my unique combination of expertise in epidemiology and neuroscience to deliver on CAMHEE objectives for CAPRI. Previous work focuses on these ‘high risk’ children primarily to examine mental illness heritability. In a crucial departure from this, Work Packages (WP) 1 and 2 exploit my collaborations in Sweden and Australia to create unique linkage across 3 population datasets. This will detail CAPRI numbers and a broad range of life outcomes disentangling effects of social adversity over time. But population epidemiology alone cannot reveal how risk creates effects in individuals. To understand ‘how’ to identify ‘who’ we target for costly interventions, WP 3 links the epidemiology with powerful neuroimaging (near infrared spectroscopy NIRS) to discover which at-risk infants of mothers with severe mental illness show abnormal cognitive development at the level of individual brain.  This work capitalises on my role at the University of Manchester, one of the leading academic psychiatry and imaging centres in the UK, to create a new Centre in Bioepidemiology. My future aim is that epidemiological profiling combined with NIRS biomarkers of cognition in individuals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Personalized Wound Dressings Based on Nanofiber Mats' (WoundCure).

assistant: **Innovation**

Wound management is a major clinical and economic problem. In 2010, public spending on healthcare accounted for almost 15% of all government expenditure in Europe. Wound management alone is estimated to make up 2–4% with an average of €6,000 - €10,000 spent on each patient per year . The annual incidence of wounds is 8 cases per 1000, higher than cancer, diabetes and cardiovascular diseases . Current strategies of wound care offer limited relief to almost 8 million patients who suffer from burns or chronic skin ulcers. The mission: NICAST is a pioneer in the development of medical devices made of electrospun polymer nano-fabrics. NICAST developed and patented a unique concept for wound dressings. The first prototype was developed, patented and pre-clinically demonstrated. The technology involved was developed in numerous national and international projects (e.g. FP7 projects VISION and NPmimetic). Moreover, the dressing composition can be tailored according to the wound care required in each step of the wound healing. The new platform consists of the e-Spun fiber based dressings produced immediately in situ by electrospinning using the new Spinner device. The device is easy to operate. It dresses the wound area in a comfortable manner without human contact. As per the above it is expected that the new dressing will reduce hospitalization and nurse time (due to home/self-use, fast healing , ease and frequency of use).WoundCure main objectives are to reach commercialization of these products by: i) Completion of first product validations and initiating of future generation dressing; ii) a multi-center clinical trial performed on donor site wounds (DSW) and partial thickness burns iii) scale-up of the manufacturing processes; iv) CE mark accreditation for the first product
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The ecology and population dynamics of Wolbachia infections in Aedes aegypti and the development of new strategies for mosquito-borne disease control' under Seventh Framework.

assistant: **Concept**

An exciting new strategy for biocontrol of mosquito-borne diseases involves the endosymbiotic bacteria Wolbachia that infect several insect species.   In the mosquito Aedes aegypti, the major vector of the dengue virus, infection with Wolbachia has been shown to greatly reduce the transmission of human pathogens including the dengue, yellow fever and chikungunya viruses.  The Eliminate Dengue project, an international collaboration, is currently developing strategies for releasing Wolbachia into wild A. aegypti populations to render them incapable of transmitting these viruses.  The operational success of this strategy relies on the rapid spread of Wolbachia through the mosquito vector population following their initial release.  However, the spread of Wolbachia depends on two main factors.  Firstly, Wolbachia incur a fitness cost on A. aegypti, which can prevent the bacteria from spreading, particularly if there is a strong fitness cost.  In order to design release strategies that will achieve spread, we need to understand the fitness effects of Wolbachia on A. aegypti and how changing environmental conditions influences these effects.  Secondly, Wolbachia needs to achieve a threshold prevalence in the mosquito population before it can spread which depends on the fitness cost caused by the bacteria.  We need to understand the dynamics of Wolbachia infection in the mosquito population in order to predict release strategies that will allow a sufficiently high prevalence of Wolbachia to be maintained.  This fellowship aims to advance our understanding of these ‘individual-level’ and ‘population-level’ processes that determine Wolbachia spread in A. aegypti in order to assist the design of Wolbachia release strategies to successfully drive Wolbachia through wild mosquito p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cellular and Molecular Basis of Regeneration' (1998-2002).

assistant: **Innovation**

In many organisms like the salamander, the planaria, the hydra the developmental programs remains open into adulthood as evidenced by their regenerative abilities, i.e. regrowing of the missing part of the body after amputation. In contrast, in most vertebrate species, this regenerative potential becomes progressively lost during development but tissue regeneration remains possible like that of the skin, the bone, the liver, the lens while the mammalian central nervous system shows little functional repair despite the presence of multipotent stem cells in the adult. This seemingly random distribution of regenerative capacities among the Metazoa is puzzling, and little is known about the genes and genetic programs responsible for this biological trait. The question is how similar or dissimilar to each other are the various regeneration processes at the molecular level? Many laboratories are currently undertaking systematic genomic / proteomic strategies to characterise the genetic components of bone fide regeneration and of tissue repair.The concept of these two meetings is to integrate the work on regeneration and wound healing in the diverse model organisms. The comparison of regeneration-specific genetic networks at work in vertebrate and invertebrate model systems will lead to a better understanding of the core mechanisms that regulate regeneration. As a consequence, the steps that are altered in regeneration-deficient species could start to be identified, which could be of utmost interest in a medical context. Indeed, recent data show that invertebrates, including planarians and cnidarians use evolutionarily-conserved genes for development and regeneration, supporting the relevance of these simple models for comparison with vertebrate systems. The first conference w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Encouraging and stimulating future RTD cooperation in the field of information society technologies between Europe and Asia-Pacific region'.

assistant: **Innovation**

IST research becomes increasingly international following the general trends of ICT development. A call to make the European IST research more open to the world is strong in the running FP6 and will be even stronger in the forthcoming FP7. At the same time, the level of international cooperation in IST research between Europe and Asia-Pacific region is far away from the level of political and economic ties between the regions.As a matter of fact, there are no European IST projects with participation of partners from South-East Asia launched so far. This situation is not only affecting progress in research, but also hampering business opportunities of European ICT industry on the world's most promising ICT market. The project sees its mission and overall objective in stimulating and enhancing international cooperation in the field of IST between EU and Asia-Pacific region by linking research communities and creating new partnerships, mapping and promoting opportunities for joint research and ICT business partnerships, facilitating inclusion of research teams from Asia into European FP7 IST consortia. It will be achieved by: - Mapping regional IST landscape and matching regional IST research capabilities with current and future EU's IST StrategicObjectives;- Running a series of scientific workshops in the region addressing several application contexts of 'ambient intelligence' concept;- Developing on-line dynamic inventory of IST groups in the region (partner search engine);- Improving public awareness of European ICT industry (European Industrial Events) and cooperative opportunities of FP7 (FP7 Information Days) and promoting bi-regional cooperation via various channels.The project consortium composed of leading European IST research and industrial players and partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Computer aided investigation of aldolase reactivity and stereoselectivity; modelling of new mutated enzymes' (2002-2006).

assistant: **Concept**

The use of enzymes for asymmetric synthesis is a powerful tool that chemists incorporated in their portfolio during the 90's. The synthesis of natural and non-natural products via aldolases is a good example. However, the enzyme's performance can be different when provided with a substrate different from its natural one. A reasonable solution to this is to modify the enzyme with protein engineering tools to render it more selective towards the desired substrate. Such a goal, however, requires the understanding of the precise mechanism and the role of different aminoacids in the achievement of the stereoselectivity.The present proposal suggests a computational approach to the understanding of some aldolases mechanism in collaboration with an experimental group. The achievement of this goal requires the development of new theoretical techniques as well as the modification of already existing ones, and represents a continuation of the proposer's research career. Emphasis is put on methods that sample the ensemble of transition paths and account for the flexibility of the enzyme.Moreover, this project will shed light to the still controversial subject of how enzymes do their job; introducing novel techniques and computationally studying for the first time some aldolases enzymes. The collaboration with the experimental group will give immediate feedback and, in the end, will lead to a faster and cheaper development of improved enzymes specifically designed for its targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart multilevel Power conditioning for AeRonautical elecTricAl uNits' in the context of a Horizon 2020 call.

assistant: **Objectives**

This proposal aims to develop and demonstrate a highly robust and reliable Intelligent Power Modules (IPMs) for the power conditioning of multiple electrical sources, optimall integrated into the electrical power generation system of the aircraft. Specific objectives are listed as follows:•Development of high performance and efficiency IPMs with a minimum impact on the size and weigth of the systems. This objective includes a design based on the most adequate topology based on advanced multilevel and interleaved topologies allowing a minimization of the passive components in terms of size and weight.•Achieve a high performance based on the use of high-efficiency wide bandgap semiconductors and its integration in the most suitable multilevel topology, at the same time that minimum size and weight are pursued.•High reliability and robustness based on a modular multilevel approach which removes the affected module in case of failure avoiding an interruption of the operation and permiting the operation with a degraded performance.•Achievement a high modularity and scalability with a high percentage of common design of the AC/DC and DC/DC modules, optimizing thus the integration of both power stages, the manufacting process and the Mean Time Between Repair.•Providing a full controllability of both power stages to higher hierarchical controller based on an advanced hardware/software architecture scheme with a multi-core approach (FPGA + DSP+ARM) that fully control each power module with a high bandwidth capacity. The developed control electronics includes advanced features that includes protection and failure management functions for a primary and fast response and the possibility for implementing autonomous and/or emergency strategies•Development of a specific modulation to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Shaping intestine epithelium using viscoelastically dynamic matrices' (EPIMECH) targeting Horizon Europe.

assistant: **Abstract**

Intestine epithelium (IE) compartmentalization and morphogenesis are profoundly influenced by intrinsic biochemical signals and microenvironmental cues in the extracellular matrix (ECM), especially viscoelasticity. Recent studies have revealed substrate mechanical properties have clear influences on intestine stem cell (ISC) fate, IE polarity, self-organization and morphogenesis. However, most of these investigations were performed in constant and static conditions, neglecting the active and dynamic nature of in vivo ECM. Furthermore, whether and how dynamic matrix viscoelasticity contributes to the emergence of symmetry breaking and tissue regionalization in early intestinal morphogenesis remains elusive so far. In this project, we propose to use dynamic hydrogel-based matrices with light-triggerable changes in viscoelasticity to study the transduction of molecular mechanosensing into collective cell dynamics during symmetry breaking and tissue patterning in IE development. We hypothesize that anisotropic substrate viscoelasticity could heterogeneously activate mechanosensing pathways in ISCs and affect ISC proliferation and differentiation, leading to changes in cell activities, sorting and tissue segregation. In brief, with dynamic substrates, we will create viscoelastic patterns/gradients by in situ light patterning and elucidate IE dynamics related to the emergence of cell shape, migration, ISC fate and tissue compartmentalization as functions of the mechanical stimuli. We also aim to identify the molecular principles of IE mechanotransduction, which will improve our understanding of IE development, morphogenesis and homeostasis. The know-how from this project will also enable the fabrication of artificial intestine-on-a-chip devices for further developmental studi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Feedback Regulated Star Formation in Diverse Galactic Environments' (FEEDGAL).

assistant: **Concept**

Three major unresolved issues in modern Astrophysics are the origin of the initial mass function of stars and it potential universality, the nature and interplay of physical processes that regulate the star formation rates and efficiencies in star forming molecular clouds, and the origin of turbulent motions in the clouds and in the interstellar medium. Over the last two decades, the effects of physical processes such as turbulence, magnetic fields, and stellar feedback on the structure and dynamics of molecular clouds have been modeled. However, a global analysis that incorporates all of these processes in a single set of simulations is still missing. The aim of this project is to provide a complete picture of the entire life cycle of molecular clouds that form and evolve in different galactic environments. Using high resolution numerical simulations, I will model the formation of molecular clouds from converging flows in the atomic phase of the ISM, the fragmentation of the clouds and the formation of stars within them, and the ways feedback from the newly formed stars impacts the dynamics of the clouds and leads to their dispersal. In additiona to exploring a large variety of galactic environments characterized by different gas-phase metallicities and magnetic field strengths, the simulations will include novel aspects such as the coupling of a state-of-the art magnteohydrodynamical code (RAMSES AMR code) with a state-of-the-art stellar evolution code (MESA code). This will allow me to follow very accurately and self-consistently the effects of feedback from massive stars on their parental molecular clouds. The results from this large set of simulations will allow me to evaluate the dependence of the shape of the IMF and of the star formation rates and efficiencies o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Geoarchaeological Relations between Architectural Space and Social Practices' (GRASSP) under Horizon Europe.

assistant: **Objectives**

The understanding of architectural space is of fundamental importance in archaeology. However, to fully comprehend architectural space, both social practices and activities (as well as their temporality) should be taken into consideration as cultural groups not only create space but also define themselves through the activities that they perform within and around it. This reflexive relationship between space and society is challenging to study, especially in Mediterranean prehistory. While part of the problem lies with the way social theory is applied to archaeology and the understanding of space, the biggest challenge consist in the poorly preserved record regarding architecture and activities, and in the lack of methodology to implement the data resolution of archaeological deposits.The proposed project, “Geoarchaeological Relations between Architectural Space and Social Practices” (GRASSP) seeks to propose a new theoretical and methodological approach to the study of space in archaeology. GRASSP propose to study the relationship between architectural space and social practices at the Mycenaean site of Pylos (Greece) by using cultural sediments as primary dataset.  GRASSP has access to a unique dataset of samples and it uses an interdisciplinary methodological and theoretical toolkit consisting of archaeological and social theory, and diverse geoarchaeological techniques in order to reveal the architectural characteristics of the buildings, identify the type of activities performed in these structures, their temporality (transformation/abandonment), and their associated knowhow. GRASSP will bring attention on aspects of material culture that are other than material while rediscussing the role played by cultural sediments in the understanding of space and practices. It