RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'New system of packaging for fresh fish'.

assistant: **Objectives**

The project aim is the development of a packaqing based on compact board for transport of fresh fish and the development of an assembling machine tfor making this packaging at docks. The new packaging system will be environmentally friendly, extremely hygienic, highly competitive and meeting the established standards. The objectives of the research are the development of a packaging system with a closed-loop material cycle, by supporting technologies that have the potential to enable more than 90% re-cycling of the materials, achieving an environmental target with a minimum expenditure. This system is also a new approach for the disposal of other packaging system which generate problematic and hazardous waste and reduce harmful emissions and productions costs. This project is aimed to solve SME's adaptation to new EC regulations while giving a new tool to increase competitive through a quality implementation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multiparametric nanoelectronic biosensors for therapy response testing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Proteases recently emerged as a promising new class of biomarkers with a broad diagnostic, prognostic and therapeutic potential for different human diseases including neurological and psychiatric diseases, several types of cancer, and immune system disorders. However, there is a lack of tools for real-time activity analysis of disease-related protease biomarkers. To address this issue, we propose to develop a highly sensitive graphene-based biosensor platform for parallel detection of multiple proteases in serum. We will exploit a new label-free sensing mechanism based on charge removal due to cleavage of designer peptides by proteases. As a specific business case, we plan to address therapy response prediction along treatment of major depressive disorder (MDD). MDD is one of the most common and burdensome mental disorders worldwide. MDD is also among the most expensive brain diseases in Europe. While effective treatments exist, there is a high variability in treatment response. There are no serum-based tests to predict personalized therapy for MDD patients. The effective treatment is identified through trial and error, a great burden for patients and the health care system. A rapid, sensitive and easy-to-use test would allow faster and more precise treatment identification, improving therapy outcomes and reducing hospitalization times. Here, we plan to detect two protease biomarkers associated with MDD. The biosensors will be validated in clinical serum samples. Arrays of graphene biosensors will be integrated on silicon wafers with a multiplexed readout matrix to realize a miniaturized sensor system with multi-analyte detection capability, high dynamic range, high precision, low detection limit, and low material consumption. The resulting platform technology may enabl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'verv: advanced home electricity analytics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Founded in 2009, Green Running are a fast growth EU SME working with a range of key electricity sector partners (Centrica, UK Power Networks). Having already established a portfolio of commercial and industrial sector electricity analytics tools, in 2014 Green Running began development of a domestic solution -verv. Verv applies patented machine learning algorithms to detect and profile all sources of electrical activity (generation, storage and consumption) active on a household's electrical system. Generating real time, itemised (iappliance level), usage data across metrics such as energy (kWh), cost (€), environmental impact (tCO2) and power quality (Hz) - verv generates valuable outputs for electricity retailers to customise/extend their services. With continental Europe subject to many of the same drivers, and several of Green Running's target customers (electricity retailers) active in multiple EU markets, Green Running now seek a H2020 Phase 1 feasibility study to validate verv's pan-European commercial and technical potential. A 5 month project including  market study, proposition refinement, partner engagement, IP strategy management, technology road map updating for multi-market operation and risk management will provide Green Running with the comprehensive knowledge, and partners it requires to first undertake a follow on multi-market field trial, and then launch verv in non-UK markets by 2020. Current projections suggest doing so can boost verv's customer acquisitions by 200%, generate annual revenues of >€6m by 2022 and an operating EBIT of €1.7m supporting creation of 38 new jobs, 23 of which will be high skilled positions at Green Running. >30,000tCO2 are also forecast to be avoided, making a valuable contribution to EU decarbonisation.This Phase 1 study w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Clinical validation of GLIX1: a small molecule that targets epigenetic changes in cancer cells to treat glioblastoma multiforme (GBM), the highest global unmet need in oncology.' (GBM) targeting Horizon Europe.

assistant: **Abstract**

Glioblastoma Multiform (GBM) patients usually die 12-18 months after diagnosis, with a 5-year survival rate of 6.8%. There are only 5 therapies approved to treat GBM and all of them provide marginal improvements of <9 months to patients’ survival. With a clinical pipeline that is constantly failing (last approval in 2004) and the lack of effective therapies, GBM remains the highest unmet need in oncology.After years of research, we discovered the GLIX family, which targets a newly discovered mechanism that is deregulated in cancer cells. GLIX1 was more effective than the current standard of care at killing several GBM cell lines. In vivo studies showed tumour regression in 100% of mice, with a tumour growth inhibition of 94%. With such promising results and an experienced team, GLIX1 is now ready for clinical validation. The support from the EIC will help us to prove the clinical safety and efficacy of GLIX1 and make it globally available through licensing to a large pharma company.


**Keywords:** Brain cancer,Rare disease,Orphan drug,Clinical validation,Glioblastoma,Epigenetics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Observational Cosmology Using Large Imaging Surveys', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The current standard model of cosmology successfully describes a variety of measurements, but its main ingredients, dark matter and dark energy, are a great mystery. ESA’s Euclid satellite is the biggest step forward towards solving this fundamental problem in physics. It is designed to reveal the nature of the dark constituents and gravity by measuring the growth of structure over most of cosmic time with unprecedented precision, but the interpretation of the data is complex: incorrect modelling of the galaxy populations, astrophysical processes or instrumental effects can easily be mistaken as evidence for new physics. To fully exploit the statistical power of Euclid, the intricacies of the data need to be understood, but we also need an accurate model of structure formation that can describe the interplay between galaxy formation, astrophysics, dark matter and cosmology.OCULIS tackles both aspects by providing the best measurements of the lensing signal and using the Euclid data in novel ways to relate observed galaxy properties directly to the matter distribution. To do so, we will (i) use in-flight data to correct for instrumental biases; (ii) measure the intrinsic alignments of galaxies that contaminate the lensing signal; (iii) exploit Euclid’s unique ability to determine the lensing signal on small scales to directly determine the stellar masses of galaxies for the first time, and to study the tidal stripping of dark matter halos; (iv) use the results to inform models that describe the small-scale astrophysics in hydrodynamic simulations, yielding robust predictions of the cosmological signals. As cosmology coordinator of the Euclid mission, the PI is uniquely positioned to achieve these objectives. The synergetic approach of OCULIS exploits that Euclid is much
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Offspring coping abilities from stressed parents exposed to global warming in aquaculture and fisheries systems' (CAPWARM) under Horizon Europe.

assistant: **Objectives**

Climate change is affecting the ecosystem’s resilience, biodiversity, productivity, and health. One major societal issue is to secure food destined for human consumption. Fish are the primary resource for essential fatty acids and proteins for billions of people and they contribute significantly to species diversity and functioning of marine, estuarine, and freshwater ecosystems. Yet, we are still limited in our ability to accurately predict how climate-change stressors will affect fish populations. To date, we are crucially lacking studies evaluating the impacts of climate change linking subfields of fish ecology such as genetics, behaviour, physiology, community dynamics or spatial ecology. Other essential aspects of climate-change impacts, such as cross-generational effects and sex-specific responses of parents that could adaptively prepare the offspring, are also often ignored. The proposed project has three main objectives: (1) investigate the effects of parental thermal stress on offspring’s coping abilities to face multiple climate stressors, (2) evaluate the impact of thermal stress on sex-specific response and decipher the sex-specific parental effects on the next generation, and (3) identify, in collaboration with stakeholders from aquaculture and fishery sectors, mitigation strategies that can mediate these effects. CAPWARM includes laboratory and field work on two valuable salmonid species for human consumption: the Rainbow trout, Oncorhynchus mykiss, and the Atlantic Salmon, Salmo salar. The first accounts for 60% of EU freshwater fish farming, while the second is the first produced marine fish but is paradoxically declared at risk in most European waters. The results will be further discussed along with management practices available to mitigate parental t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Preventing Radicalisation Online through the Proliferation of Harmonised ToolkitS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

PROPHETS will look at redefining new methods to prevent, investigate and mitigate cybercriminal behaviours through the development of a coherent, EU-wide, adaptive SECURITY MODEL, built upon the interplay of the human factors within the new cyber ecosystem and capable of addressing the four fundamental dimensions at the core of the phenomenon: 1. early identification of security threats; 2. investigations within a new public-private governance; 3. Increased complexity of the response due to the expansion of the security perimeter towards new societal fields and the emergence of challenging jurisdictional problems; and, last but not least,  4. perception of security and freedoms among citizens, which requires a new communication strategy for LEAs and security policy makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Clothes Perception and Manipulation'.

assistant: **Innovation**

This project aims to advance the state of the art in the autonomous perception and manipulation of all kinds of fabrics, textiles and garments.The novelty and uniqueness of this project is due chiefly to its generality. Various garments will be presented in a random pile on an arbitrary  background and novel ways of manipulating them (sorting, folding, etc.) will be learned on demand in a real-life dynamic environment. The removal of previously indispensable deterministic assumptions about the modes of the textiles presentation and handling is expected to lead to greater robustness, reliability, and a wider field of applications.CloPeMa's main objective is closer integration of perception, action, learning, and reasoning. Perception means integrated haptic and visual sensing, recognition, and support for perception-action reactive cycle. Actions will be performed by a cooperating pair of robotic hands, part of the CloPeMa experimental testbed duplicated in three project partners. The hands will combine all state of the art solutions for manipulation of limp material: variable impedance actuation on a compliant hand mechanism architecture using smart materials and tactile sensorization with artificial skin on large areas.Goals and actions will be learned in a dynamic environment. All components will be subject to statistical learning, spatial reasoning, and high-level reasoning. Thus integrated, CloPeMa is aimed at functionalities that had hitherto proved elusive for systems using only some of these parts in isolation.Data and procedures to obtain them on the experimental testbed will be collected and made public. Results will be measured and analysed within three carefully defined demonstrator projects of increasing difficulty.The consortium includes expertise in all th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Voluntary Industrial Code of Practice for IST-enabled work across national borders' in the context of a Fifth Framework call.

assistant: **Objectives**

Voluntary Industrial Code of Practice (VIP) refers to a unilateral agreement among international companies to consider ethical aspects when establishing and carrying on IST-enabled work across national borders. By this, the project invites large international companies to take part in the shaping of a humane global Information Society and at the same time contribute to fair global competition. The objectives are: 1 to clarify the essence of business ethics and to review relevant existing codes of conduct applicable for work across national borders and to develop a tool that facilitates analysis of consensus building process; 2 to suggest an ethical code for IST-enabled cross-border work and to obtain endorsement of the VIP-Code by 100 international companies. The research activities consist of two sections. The first is to describe the nature of ethics in general, to identify value systems and clarify linkages to business ethics and strategies. The methodology is in the first place literary surveys, but also dialogues with VIP industrial participants. The work will result in a comprehensive discussion of the topic and provide a knowledge base, which will be used particularly in the VIP Code formulation process. The second includes systematic scanning of existing codes of conduct, ethical codes and multilateral agreements on human right, work conditions, environment protection, international business relations and information technology use and transfer. In addition, this section includes development of tools for analysis and consensus building - based on 'fuzzy logic', which is able to cope with multidimensional values and combinations of ethical codes. In parallel to the research, development work is carried out on VIP code formulation, expansion of the industrial part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of new materials and processes to enhance specialty gases separations' (SPECSEP).

assistant: **Innovation**

This project concerns the development of novel materials (nanoporous carbon membranes and liquid absorbents) and their implementation in innovative gas separation technologies. The work will be directed towards the optimisation of the materials' performance for specific end-applications, which are found to be of practical and economic interest. These are: removal of carbon dioxide and nitrogen from nitrous oxide and xenon-based closed anesthetic circuits (low-flow anesthesia), removal of carbon dioxide from life-supporting systems and production of high purity oxygen from air. The project involves therefore several levels of development, going from material synthesis and fundamental characterization, to process implementation and assembly of functional models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SME Led Malaria Vaccine Initiative', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This SME coordinated and dominated STREP will investigate new malaria vaccine candidates with the objective of taking at least one through to GLP pilot scale up. The most promising candidates will undergo in vitro and in vivo testing, lead optimisation, safety and toxicology testing according to GLP standards. The combination of efforts presented in this STREP will generate several recombinant measles viruses expressing a variety of malaria antigens based primarily upon MSP-1 and secondarily on AMA-1.In order to maximise on the capabilities of the SMEs and two of the leading European malaria research institutes, this STREP will concentrate on six workpackages: WP1 Project Management; WP2 Development of transgenic humanised mice, Delivery of malaria antigen coding sequences; WP3 Delivery of block 2 malaria antigens; WP4 Hybrid malaria antigen development, Primate challenge studies; WP5 Development of MeVs expressing multiple blood stage malaria antigens; WP6 Validation and Biosafety evaluation of candidate vaccines.The timeframe and budget allocated directly reflect the requirements for such a proposal, including contingency plans. In addition, this STREP application, coordinated by EtnaVax, will compliment the detailed work laid out in other larg er European research projects and proposals. As such it forms an essential stepping-stone in the trans-European malaria vaccine initiative.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of an accessible platform for  ex vivo site specific post-translational modifications of proteins'.

assistant: **Innovation**

The incorporation of unnatural amino acids (more than 50 to date) into proteins in vivo has resulted in the generation ofproteins with novel chemical, biological, and physical properties. However, some unnatural amino acids possess properties,such as an inability to cross the cell membrane or a level of toxicity dangerous to the organism, that restrict their incorporationinto proteins in vivo. In addition, even when an unnatural amino acid crosses the cell membrane, its transport efficiencywithin the cell is very low. We propose to overcome these limitations by exploiting translational components evolvedtRNA-synthetases and their cognate suppressor-tRNA from Archea for the incorporation of an array of unnatural amino acidsinto proteins in vitro in a cell-free protein translation system. The expressed recombinant proteins containing the unnaturalamino acids will be purified from the reaction mixture and used for further research. Using the cell free system, first we willdemonstrate our new approach by incorporating novel unnatural amino acids, i.e., thiolysine analogues, into proteins usingthe broad substrate specificity of evolved tRNA synthetases. We will then incorporate a thiolysine analogue into PCNA forthe site-specific ubiquitination and SUMOylation of these proteins for in vitro studies of the interactions between PCNA andinteracting proteins and to follow the progress of the replication fork. This unique approach will show for the first time the useof evolved synthetases in a cell free translation system, with the advantage being that previously un-incorporable unnaturalamino acids can be incorporated using this approach. Our overall aim is to enable the introduction of new functionalities intoproteins.