RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Regional Intellectual Captial - Development and application of a methodology for European regions'.

assistant: **Concept**

Although current regional RTD policy has focussed heavily on cluster policies, the methodological base for assessing and developing the heterogeneous outcome of these efforts is surprisingly meagre. There is a lack of approaches for capturing and developing intellectual capital - especially intangible structural and relational assets - that lie at the heart of these RTD policy interventions. At the same time, management sciences have seen the development of Intellectual Capital (ICR) as a tool to capture these innovation relevant intangibles on the level of the organisation. RICARDA aims to transfer ICR on the level of regional RTD networks or clusters. It will therefore help improve regional RTD policy by developing and applying an ICR methodology for collaborative research activities in European regions. ICRs will be jointly drafted by regional institutions, cluster managers and specialized research institutions for differing pilot-clusters in each of the participating regions, identifying opportunities f or improving private and public engagement in R&D activities. The potential for establishing an ICR-based policy learning framework within each region will be explored with regional RTD stakeholders. The findings in the four participating regions will be discussed in an international comparison and will finally lead to a refined methodology for the introduction of ICR within regional RTD policies which will be disseminated in various ways. The participating regional institutions in Stockholm (SE), Stuttgart (D), Styria (A) and West Transdanubia (HU) are all actively involved in cluster-development activities. These regions represent a wide spectrum in terms of regional institutional capacities, economic structures, R&D priorities etc. The four participating research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cellular BIOtechnology for prognosis and monitoring in renal TRANSplantation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Kidney transplantation is the treatment of choice for patients with end-stage kidney disease (ESKD). However, although surgical techniques and postoperative care have greatly advanced, renal transplantation is not empty of challenges.The most important challenge is to achieve the long-term survival of the transplanted organ. Graft survival depends on the ability of the recipe of not rejecting the “foreign organ”. Rejection is a naturally occurring process triggered by a biological response of the immune system, which main function in the body is to defend it against infectious organisms and other invaders. As such, the immune system is prepared to reject a “foreign organ”, something that is nowadays prevented by prescribing immunosuppressive therapies to the patients for their whole life. However, the use of immunosuppressive therapies entails important problems. On one side, suppressing the immune system implies severe side effects like opportunistic infections, cancer and other severe malignancies. On the other side, even under immunosuppressive therapies, about 50% of transplanted kidneys are lost during the first 10 years and this is because of an immune response usually described as chronic rejection. Therefore, the major challenges in ESKD deal with avoiding the side effects associated with immunosuppressant drugs and avoiding chronic rejection. In the TRANSBIO project we aim at bringing to the healthcare market a technology for efficient clinical management of patients undergoing a kidney transplant based on a simple and non-invasive blood test. Considering that worldwide, the number of people receiving renal transplantation annually is estimated at about 80,000 people, growing by approximately 6% annually and representing a prevalence of about 700 patients per m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification, Preparation and Dissemination of Hydrogen Safety Facts to Regulators and Public Safety Officials' (HYFACTS).

assistant: **Concept**

HyFacts aims to develop training material for Regulators and Public Safety Officials, which are responsible persons and work for entities, having to position themselves in the increasing number of upcoming installation of hydrogen-related technologies. The training material will focus on the fundamental aspects of hydrogen safety and on the safety approaches and criteria developed in standards and according to which hydrogen systems are engineered for the safe use of hydrogen under all circumstances.Hydrogen (H2) and its related technologies are relatively new to institutions which are dealing with issues like building regulations, local regulations, public safety and permission of technical installations. Most of the staff of these institutions does not have the necessary knowledge to judge on safety aspects based on real facts but tend to take decisions on the basis of either obsolete or incomplete knowledge or refuse to take any decision at all. This situation leads to heavy delay of decisions or to technically unreasonable, costly and sometimes also very ineffective safety measures to obtain the approval for a hydrogen installation or the allowance to install or operate hydrogen related technologies.Significant efforts will be devoted to identifying and prioritizing the audiences that would need to be trained to facilitate the commercialization of hydrogen and its related technologies. A vision and road-map for the establishment of permanent training activities for the targeted audiences by recognized institutions, along with the proposal specific initiatives will be an important outcome of the project.A large amount of new data on the behaviour of hydrogen has been developed during the last years (e.g. HySafe). These are now being applied for the design of new prod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Collaborative OWA robots for drilling and fasteners insertion in assembly lines' (CORDIAL) under Horizon 2020.

assistant: **Objectives**

The overall objective of the CORDIAL project is to develop a new compact drilling and fastening unit for One Way Assembly. The effector has to be used by operator or lightweight industrial robots. Six sub-objectives contribute to achieve such a goal:- To define how robots and operators can interact in an OWA cell. - To evaluate a typical assembly layout and endeavour new OWA opportunities and risks assessment.- To develop compact automated effector(s) for drilling, fastening and counteracting- To establish a test plan according to requirements for commercial aircraft structures.- To demonstrate the technology, realize specimens and test the proof of concept under real conditions.- To disseminate the results widely to maximise the impacts of the CORDIAL project.To complete the project, the capabilities of the partners include:-SONACA Engineering, industrialization, qualifying and manufacturing means for small subassemblies such as slats of landing gear doors, including composite manufacturing.-AEROSPLINE innovative engineering in robotics and drilling and fastening effectors. Including innovative fastener with sealant feeding, which permits to simplify and lighten any effector.-XLIM Advanced sensor vision technologies using small size vision sensors and capable of multiple information computation: coordinate positioning, centring, normality, hole and fastener quality.The CORDIAL project is perfectly in line with the Clean Sky 2 objectives since it will contribute to develop eco-friendly processes (reduction of the impacts on health, creation of sustainable capabilities), to demonstrate new technologies (human/robot close collaboration in the aeronautics, new structures design), improve the European competitiveness (lighten the assembly process, cost reduction and shorten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'EXPERIMENTS At ELETTRA, SOFT X-RAYS RADIATION FACILITY'.

assistant: **Objectives**

Elettra is a new third generation Synchrotron Radiation Facility located in Trieste which has just opened two beamlines to external users. Two more are going to be ready by July 1995. Elettra is a high brilliance storage ring with record photon flux and energy resolution beamlines in the soft X ray range. At the moment Elettra advanced specifications make it unique of its kind in Europe The characteristics of the available beamlines at the beginning of 1995 or in the following months are: i) SuperESCA:  This beamline works in the soft Xray range (100+1500 eV). It allows to take high photon flux and energy resolution spectra. It is of special interest in core levels photoemission spectroscopy of elements of technological importance. Due to its fast data colection time (an ESCA spectrum can be taken in less than one second) it allows tirne resolved experiments. ii) Pbotoemission Spectroscopy:  This beamline works in the VUV energy range ((2O+850 eV) and makes it possible to take photoemission spectra of the valence band of solids with unprecedented combined high energy, momentum resolution and photon flux. These features are specifically directed toward experimental studies on the electronic structure of new high Tc superconductors, semiconductors and semiconductor-metal heterojunctions. iii) X-ray Diffraction:  This beamline allows crystallographic measurements of very small biological crystals with unprecedented accuracy. iv) ESCAmicroscopy:  It allows to make scanning ESCA microscopy measurements with a lateral resolution of 1000 A. It is ideal for the study of composite materials. The research areas which can be covered with these beamlines an: solid state physics, surface science, material science, catalysis, corrosion, crystallography, biochemistry, applied surface
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach' (FREIA), addressing dissemination and exploitation.

assistant: **Impact**

The FREIA consortium aims to close gaps in scientific knowledge on the mechanisms by which EDCs can affect female reproduction during specific life stages and will provide test methods to address this. The FREIA consortium has human tissue models that span the entire life cycle from fetal ovarian and adrenal tissues to child and mature ovarian follicles, that will be used identify human relevant biomarkers of EDC exposure. We will measure chemical exposures in follicular fluids and molecular profiles in granulosa cells from two IVF cohorts, and link these to fertility outcomes and patient journal information, including life-style factors and workplace. We will perform in vivo rodent studies to capture susceptible windows of exposure and identify novel endpoints for female reproductive toxicity that may be implemented in OECD test guidelines. We will provide in vitro test methods, according to OECD guidelines, for molecular and cellular events that have been implicated in female reproductive toxicity. These include ER-beta activity, GPER activity, ovarian-specific steroidogenesis, oocyte maturation and competency and hypothalamic pulsatile GnRH secretion. We will also develop QSAR models to predict interaction with aromatase and PPAR-gamma. By integrating our data from in vitro studies with primary human tissues, human exposure data from fetal and follicular fluid samples and our in vitro and in vivo research findings, the outcomes of FREIA are directly applicable to the human situation. AOPs will be developed that will form the basis for a test strategy to assess female reproductive toxicity upon exposure to EDCs, in a regulatory context. Furthermore, by expanding our scientific knowledge, the FREIA project will provide better information on EDC-related female reproduct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Continuous Diaphragm Monitoring of mechanically ventilated patients' (DiaMon) under Horizon 2020.

assistant: **Objectives**

Respinor aims to seize a major market opportunity through the clinical validation, technology maturation and commercialization of a unique ultrasound technology for Diaphragm Monitoring – DiaMon. DiaMon is a non-invasive ultrasound device that is designed to provide precise, continuous and real-time information of diaphragm function. The diaphragm is the main muscle involved in breathing.Treatment with Mechanical Ventilation (MV) results in high costs for healthcare systems. The incremental cost of MV is estimated to be €1,500 per patient per day. With an estimated 1.35 million MV patients in the EU per year for an average of 4-5 days, this represents an expenditure of at least €8.1 billion annually. Therefore, it is highly important both clinically and economically to bring patients off MV and back to normal, spontaneous breathing as quickly as possible. There is currently a severe lack of accurate and cost-effective solutions to support the MV process. Respinor aims to fill this gap, by demonstrating and commercializing a cost-effective and user friendly ultrasound device, being the only effective non-invasive alternative to invasive catheter based solutions.Under Eurostars and Horizon 2020 SME Phase 1 grants, Respinor has developed a first version of DiaMon and initiated clinical studies. Preliminary results are very promising. The overall objective of H2020 Phase 2 is to: 1. Demonstrate in large clinical trials (700 patients) that DiaMon can reduce MV failure compared with standard of care and 2. Further develop DiaMon into a commercial product with high usability and acceptance in the ICU setting. The accomplishment of the proposed project objectives will bring major benefits to Respinor with a forecast significant cumulated turnover by 2025 in the ICU MV market se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Toward Innovative Methods for Combustion Prediction in Aero-Engines'.

assistant: **Objectives**

The aim of the TIMECOP-AE project is to provide the necessary combustion prediction methods that enable the development of practical advanced combustion systems for future engines that will reduce emission levels and fuel consumption. Predictive tools are required to be able to reduce NOx emissions, to decrease the development time and costs of new combustion systems and to improve the operability of lean-burn combustion systems.All promising approaches to satisfy future emission levels regulations are based on lean combustion technology. However, lean combustion compromises combustor operability, including ignition, altitude re-light, pull-away, weak extinction performance and thermo-acoustic instability behaviour. It is of prime importance to evaluate this transient behaviour in the design stage to ensure good operability. Without these tools the development of these advanced combustion systems will depend on many rig tests.These are costly and time consuming and will reduce our competitiveness. During the last five years big advances have been made in the field of reactive Large Eddy Simulation (LES) with gaseous fuels. This approach gives promising results with respect to turbulence modelling and can be used to model unsteady processes. Within this proposal the LES tools will gain the capability for modelling the combustion process within conventional and Low Emission combustors over a wide range of operating conditions on liquid fuels.The operating conditions include mentioned transient phenomena. To be able to model these phenomena improvements are required in the models of turbulence, chemistry, turbulence-chemistry interactions, and liquid spray models. The methods and models will be evaluated against high quality validation data, which will be obtained by sever
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Circular RNAs to reverse pathological remodelling of the injured heart'.

assistant: **Concept**

Heart failure (HF) is a most common cause of mortality with currently >60 million of affected patients. Numbers will increase due to socioeconomic factors and as a result of the current COVID-19 pandemic. A major underlying cause of HF are cardiac remodelling processes at the molecular, cellular and tissue level. We will here focus on noncoding circular RNAs (circRNA) involved in two distinct forms of cardiac injury, chemotherapy-induced cardiotoxicity and SARS-CoV-2-infection, where currently no specific treatment strategies are available to reverse disease pathology. First proof-of-concept studies targeting the cardiac remodelling process by noncoding RNA modulation have been pioneered by us and were recently tested in a world-wide first clinical phase 1b study in HF patients. Within the family of non-coding RNAs, circRNAs are stable and species-conserved and thus ideal drug targets. We discovered multiple molecular circRNA signatures during remodelling of cardiac cells and tissues from mice and patients. We now aim to lift our research to its next inflection point with the following steps and interconnected objectives: a) discover key functional circular RNAs involved in remodelling processes by functional CRISPR-Cas library screening; b) validate circRNAs by manipulating human living beating myocardial tissue, c) explore their mode of action; and d) perform targeted cardiac delivery approaches of selected candidates in both chemotherapy-induced cardiotoxicity and SARS-CoV-2-induced cardiac disease models. A combination of bioinformatic, molecular and physiology-based methods, unique established noncoding RNA drug discovery pipelines, availability of modern S3-safety labs, large clinical biobanks and (fresh) human cardiac tissue for slicing preparations form the basi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Centre of Advanced Materials Research and Technology Transfer CAMART²'.

assistant: **Innovation**

CAMART² (‘Excellence Centre of Advanced Material Research and Technology Transfer’) project is aimed to upgrade the existing Centre of Excellence at the Institute of Solid State Physics, University of Latvia (ISSP), which was established in 2001 by project CAMART realised within EC FP5.The current project CAMART² is based on a long-term partnership between ISSP, KTH Royal Institute of Technology – the largest technical university in Sweden and RISE Research Institutes of Sweden. ISSP is renowned for its scientific achievements in applied materials physics for micro- and nanotechnology, electronics, photonics, functional coatings etc. and related theoretical and characterization capability.The vision of CAMART² is to establish ISSP as the most important centre of excellence for education, science, innovation and technology transfer in the Baltic States. ISSP will also become the hub for a collaboration and technology transfer platform (called ""RIX-STO"") for materials physics based high technologies, including scientists, entrepreneurs, investors and policy makers on both sides of the Baltic Sea. The commitment from the Swedish partners assures successful modernization of ISSP, including an overall refinement of the educational programs, strengthening of the research and development activities towards higher technology readiness levels, establishment of an innovation system and Open Access Laboratory, as well as ISO 9001 certification. The partners will be active in an ambitious program for networking and outreach to make academia and high-tech industries in the region around Riga and Stockholm flourish with respect to scientific results, economic growth and increased competitiveness. The region will benefit from an injection of highly educated young people, closer coll