RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Industrial Academic Initial Training Network towards focused treatment of age-related motor symptoms' (2007-2013).

assistant: **Innovation**

Gait and postural control impairments, and falls are ubiquitous among the elderly, and lead to enormous personal, occupational and health care burden. Especially patients with PD are severely affected by the progressive deterioration of these gait and postural control mechanisms. Elucidating mechanisms of age- and disease-related motor control impairments and devising focussed treatment strategies to counteract these symptoms represent major challenges for future research. Moving beyond focuses on the role of supraspinal motor control mechanisms in ageing and PD. It will span the entire spectrum from basic understanding of these mechanisms, over diagnostics to therapeutic applications of supraspinal motor control deficits. In particular, we aim to pursue the following aspects: (i) pathways of the basal ganglia, (ii) balance and postural control, (ii) sensorimotor integration aspects, (iii) fractal properties of gait, (iv) freezing of gait, and (v) central adjustment strategies. We will employ promising diagnostic strategies and tools such as (i) electroencephalography during locomotion, (ii) virtual reality, (iii) body worn movement monitors, and (iv) instrumented movement assessments. Treatment strategies in Moving beyond include (i) therapeutic cues, and (ii) modelling of an individualized training proposal. The network consists of a rare combination of experts from basic and translational research as well as from the industry. They will cover the entire range of expertise necessary and utilize cutting edge technology to educate students and fellows in the complex problem of the impact of supraspinal motor control mechanisms in ageing and PD. The comprehensive inter-sectoral and multidisciplinary training program will comprise a unique set of state of the art scieniti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Definition of a genetic network involved in congenital heart disease'.

assistant: **Innovation**

This application focuses on transcriptional networks that govern the development of a heart region commonly affected by congenital heart disease (CHD).  The major goal is to provide the clinical and basic science research communities with a validated list of interconnected genes required for normal heart development. To achieve this goal, we have recruited 6 European groups of scientists strongly committed to CHD research.  The participants bring to the consortium significant resources and credible synergy. The entry point for the interrogation and perturbation of cardiogenic gene networks will be the transcription factor Tbx1, the major gene for 22q11.2 deletion syndrome, a common genetic cause of CHD. The project has three specific aims: 1) To define the roles and interactions of T-box transcription factors in cardiac outflow tract (OFT) development. Our hypothesis is that a critical balance of Tbx1, 2, and 3 is required to regulate homeostasis of a specific population of cardiac progenitors and their interactions with non-cardiogenic cells. 2) To define gene networks perturbed in OFT developmental defects. Innovative approaches will identify the transcriptional targets and protein interactors of Tbx1.  Candidate genes will be validated in vitro and in vivo using mouse and zebrafish models. In addition, we will perform extensive transcriptome analyses using biopsy material from CHD patients in order to integrate animal and patient data. 3) To integrate gene expression, cell lineage distribution and phenotype data. Normal heart morphology is achieved through a concerted gene expression program and the integration of molecular signals and tissue interactions.  Aided by 3-dimensional reconstruction of gene expression patterns and phenotypic information, we will integrate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tick-Virus Interactions Shape persistence and Transmission OF Flavivirus pathogen in tick vector' (TVISTOFF).

assistant: **Concept**

In Europe, tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis, the most important viral life-threatening disease transmitted by ticks. Interactions among the virus, tick and host are inseparable and paramount for a successful circulation of TBEV in an enzootic cycle. Nevertheless, research in this area has predominantly focused on TBEV pathogenesis in vertebrate hosts. Limited knowledge on virus-tick interactions points out to lack of systematic studies and warrants research implementing novel virus-tick models. Therefore, the goal of this fellowship is to investigate the roles of molecular factors of TBEV virulence and tick neurosecretory compounds in adaptation and transmission of TBEV. The innovative concept involves a development of fluorescently labelled TBEV mutants by reverse genetics, implementation of host-free artificial membrane tick feeding system, and characterising components of tick neuroendocrine systems. The interdisciplinary approach of interconnecting the applicant's unique skills in tick physiology and bacterial tick-borne pathogens, expertise of the host group in arbovirology and capacity of partner group in physiology of tick neuroendocrine systems will be instrumental in widening knowledge on virus-tick interactions. Developed tools and obtained results will provide invaluable foundation for research of other neglected tick-borne viruses. Taking together, this fellowship will enable the applicant to reintegrate into the host organisation in his home country, to carry out innovative research, and ultimately to reach professional maturity as an independent investigator.


**Keywords:** Tick-borne encephalitis virus, ticks, pathogen transmission, reverse genetics, reporter virus mutants, in vitro tick feeding, neuroendocrinology, neu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Switching Polytypes and Symmetries by Discrete vdW Sliding' (SlideTronics).

assistant: **Innovation**

While the artificial design of pristine crystalline structures and the construction of dedicated periodic playgrounds for atoms and electrons in a solid have transformed our world, much is yet to be explored. I posit that the marvels of van der Waals polytypes should go much beyond and suggest that they offer a remarkable opportunity to rapidly, efficiently, and distinctively swap between numerous different crystals, symmetries, and dispersions at will.We have recently reported several new crystals made from identical 2D layers that differ only by their stacking symmetry. These perfectly commensurate and periodic di-atomic polytypes result in distinct electric potential steps and exclusive ladder-like polarizations owing to their various combinations of broken inversion and mirror symmetries. Our current research focus is mono-atomic polytypes that break both symmetries and offer further fundamental insight into the purely geometric impact of the atomic positions in the unit cell. Our preliminary experiments on graphitic polytypes detect novel internal polarizations, placing us in a great position to explore its interplay with superconductivity and orbital magnetization.The key challenge is to break the polytypes out of their commensurate meta-stable stacking and force the layers to slide at particular interfaces, only along armchair lattice orientation and for discrete inter-atomic distances.     We have recently observed that such switching is possible using external electric fields, but only in the case of polar di-atomic bilayers. The swapping involves a thin incommensurate boundary wall encompassing a single stacking fault, which may slide rapidly in a super-lubric manner.Building on our ability to construct and distinguish adjacent polytypes, we aim to develop met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transmission system operation with large penetration of Wind and other renewable Electricity sources in Networks by means of innovative Tools and Integrated Energy Solutions' (TWENTIES), addressing dissemination and exploitation.

assistant: **Impact**

A group of 6 Transmission System Operators (Belgium, Denmark, France, Germany The Netherlands and Spain) with 2 generator companies, 5 manufacturers and research organisations, propose 6 demonstration projects to remove, in 3 years, several barriers which prevent the electric system from welcoming more wind electricity, and wind electricity from contributing more to the electric system. The full scale demonstrations aim at proving the benefits of novel technologies (most of them available from manufacturers) coupled with innovative system management approaches. The contribution of wind energy to the system will show how aggregated wind farms can provide system services (voltage and frequency control) in Spain. The aggregation of wind farms with flexible generation and loads will be demonstrated in Denmark using a scalable IT platform developed by a generator. Increasing the flexibility of transmission networks will be tested in Belgium (existing sensors and coordinated power flow control devices avoiding possible large scale instabilities induced by wind farms in the CWE region) and in Spain (dynamic wind power evacuation capacity using real-time computations based on short-term generation forecasts and use of a mobile Overload Line Controller). Off-shore wind farms are addressed from a security viewpoint. Secure HVDC meshed networks will be validated in France using simulations and full scale experiments of two different HVDC circuit breaker technologies. Off-shore wind farm shut downs under stormy conditions will be demonstrated in Denmark using the world largest off-shore wind farm with balancing power provided by the Norwegian hydro capacities through a HVDC link. The experimental results will be integrated into European impact analyses to show the scalability of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integration of III-V Nanowire Semiconductors for next Generation High Performance CMOS SOC Technologies' (INSIGHT).

assistant: **Concept**

Overall objective: to enhance advanced CMOS RF and logic capability through the use of III-V heterostructure nanowires monolithically integrated on a silicon platform.INSIGHT will focus on:-Development and evaluation of the performance of silicon based, 94 GHz III-V nanowire MOSFET low-noise amplifiers. The technology opens a path for cost reduction of key mm-wave components for high bandwidth wireless applications.-Development of III-V nanowire MOSFETs on Si with breakdown voltage of 6 V, and evaluation of their performance in millimeter wave (90 GHz) power amplifier circuits. These devices will increase output power available from Si CMOS compatible mm-wave technologies with benefits for transceiver range and sensitivity. -Realisation of basic building blocks for future RF-circuits including mixers, Voltage-Controlled Oscillators, and frequency dividers for prescalers using silicon based III-V nanowire MOSFETS. -Development of science and technology for all-III-V nanowire CMOS on silicon targeting future technology nodes for 10 nm and below.  This will be validated by the implementation and dynamic characterisation  of a flip-flop as demonstration of the co-integration of III-V n- and p-type nanowire MOSFETs.INSIGHT is a strong consortium consisting of 7 partners with complimentary and well-documented experience in III-V MOS technology and millimeter-wave circuit design and implementation. Our main outcomes include : a)Technology toolbox including, materials, processes and integration for III-V n- and p-channel MOSFETs on a silicon platform, b) III-V nanowire MOSFET RF-transistor technology, c) Circuit design library, d) Circuit demonstrators with a clear technology path towards higher TRLs and commercialization.  Our vision is to use III-V nanowire CMOS technology fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Atropenantioselective lactamizations using an intramolecular Staudinger ligation strategy', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The present proposal concerns the development of atropenantioselective localizations using an intermolecular Standing legation strategy. The study will be undertaken in the Homestead/Van Maureen group at the University of Amsterdam. This group has recently disclosed a novel strategy for the synthesis of medium-sized lactase, and is currently developing the use of the /nframolecular Standing legation in difficult localizations, towards an improved synthesis of several homo- and heterodetically closed cyclopeptides. Future work proposed herein will be dedicated to the particularly challenging stereo selective synthesis of cyclopeptides exhibiting atropisomerism. Striking examples of related bioactive products are RP 66453 (neurotensine receptor antagonist) and the glycol part of vancomycin (glycopeptides antibiotic)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced Technology to Optimize Maritime Operational Safety, Integration & Interface' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The strategy of ATOMOS II is to enhance maritime safety and efficiency by combining a serious evaluation of user needs with the solid technology development skills of European marine automation companies. The project will proceed smoothly from definition of user requirements through prototype implementation, ending with simulator-based validation and assessment of benefits.The project has two objectives: -Ship Control Centre Design and Assessment (Area 6,3,3/24)To develop a conceptual standard for a ship control centre working environment including the corresponding human machine interface which enhances safety and efficiency through improved operator comfort, workload and awareness, screen presentation and other relevant factors.The design of the ATOMOS II ship control centre shall take full account of human capabilities, limitations and performance limits as its constraints. Advanced information processing shall be developed to enhance the capabilities ot the user to achieve greater safety and efficiency.- Integrated Ship Control Design and Assessment (Area 6,3,3/25)To enhance maritime operational safety and efficiency through an improvement of ship-borne command, control, alarm and information systems as much as practically possible, taking cost-benefit issues into account. Objective to be achieved through design, implementation and subsequent validation of a conceptual standard for a safe, efficient and open ISC system which allows cost-effective interoperability and interconnection between system modules from different suppliers. In order to facilitate interoperability ATOMOS II shall define a harmonized user interface and provide a standardized process network.The ultimate objective of the proposed research relates to the widespread acceptance and subsequent adapt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Climate change and Geodetic deformation' (GEOCLIME) targeting Horizon 2020.

assistant: **Abstract**

Environmental fluid circulation (oceans, atmosphere, hydrology) induces detectable 3D deformation of the solid Earth (several mm), known as loading effects. These are mainly seasonal, with additional shorter and longer term signals. Since climate change modifies regional and global circulation, it will also impact on loading deformation. These effects are not considered in climate projections despite their non-negligible impact e.g. for sea level rise flooding prediction. This multidisciplinary fellowship will improve understanding of the water cycle and the impact of climate change on Earth’s shape via the study of loading effects using accurate space geodesy and modelling. Combining an innovative method and highly complementary data in terms of both spatial and temporal resolution - Global Navigation Satellite System (GNSS) and space-borne gravity data (GRACE) - this fellowship will allow precise determination of loading effects and to invert for associated mass variations. This will identify the different sources, long term (e.g. post glacial rebound) and short term signals (e.g. recent variations in hydrology, ice sheets, extreme climate events) using long, highly accurate time series. This fellowship will:  1) estimate the impact of anelasticity in loading deformation models and improve and validate these forward models especially for rapid effects (hours to weeks); 2) use inverse modelling of deformation linked to climate change to better observe the water cycle, and assess local implications for sea level change and natural hazards. It will provide high level training and international exposure from the world-leading geodesy group at Newcastle University (UK), taking advantage of the host’s and fellow’s complementary expertise. It provides an invaluable opportuni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dependence of Synaptic Plasticity Rules on Synaptic Location in Neocortical Layer-5 Neurons' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

A striking feature of a neuron is its dendrite tree. Among other things, dendrites convey information from synaptic contacts with other cells. Learning and memory rethought to be mediated by the activity-dependent modification of synaptic connective strengths, a notion termed synaptic plasticity. Rules for plasticity describe the activity that modifies the strength of a synaptic connection; properties such as diameter and length of the dendrite branch on which a synapse is located will influence this activity. Hence, synaptic plasticity rules depend on dendrite properties as well as on synapses location in the dendrite tree. I propose to examine the location dependence of plasticity rules in cortical layer 5pyramidal neurons, which have apical and basal dendrite regions with distinct synaptic inputs. I will address how the different biophysical properties of these regions underlie synaptic plasticity with the ultimate goal of deriving a detailed computer model of dendrite biophysics and its role in plasticity. I have previously studied plasticity rules in one location of layer 5 neurons using methods that have limited me to describing plasticity, without addressing underlying mechanisms in great detail. In Dr. Hausers lab, I will learn several advanced biophysical methods that I will use towards my goal of understanding synapticplasticity.The biophysical methods I will learn in Dr. Hausers lab will add to my scientific breadth by complementing my expertise in electro physiology and molecular biology. This will help me when I ultimately have my own lab. Finally, being Swedish, I believe Will benefit from learning more about science in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Selectivity Database-2'.

assistant: **Concept**

This proposal is a logical follow-up of concerted action FAIR-CT96-1531 Selectivity Database (SELDAT), in which the specifications and conditions for use and maintenance of a selectivity database were investigated.. Fishing gear technology and selectivity, stock assessment, information technology and database experts from fourteen organisations in The Netherlands, Scotland, Denmark, Belgium, Sweden, Norway, Portugal, Greece, Germany, and France will cooperate in three small teams to define a detailed requirements specification for the selectivity database and acceptance tests for the database.Through a tender a consultant will be contracted to carry out the physical design, the implementation and testing, as well as the development of a data entry program. Data will be typed in using this data-entry program by the participating institutes. The database will be demonstrated to users in a workshop at the end of the project. An international Steering Group will be established with leading fishing gear and stock assessment scientists to give guidance on the management of the project, to advice on the database development process to give approval to major decisions within the project and to ensure that the end product fulfils the defined specification. The project duration is twenty-eight months.