RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanocrystalline oxides for selective oxidative electrocatalysis' under Seventh Framework.

assistant: **Concept**

The proposed project aims at  understanding of the electrocatalytic activity and selectivity of the nanoctrystalline oxide electrodes in oxidation processes.  Nanocrystalline forms of electrocatalytically active oxides based on pure RuO2 and Co3O4  and on the oxides derived from those by hetero-static substitution will be synthesized by advanced solution based techniques to obtain single phase materials with defined particle size and shape. Prepared materials will be characterized by diffraction techniques, X-ray absorption spectroscopies (EXAFS/XANES) and electron microscopy (SEM/HRTEM) to obtain information about the structure and surface orientation. The electrocatalytic activity of the prepared materials with respect to industrially important electrocatalytic processes – chlorine and oxygen evolution will be characterized  using   and common electrocatalytic techniques (CV, DEMS, impedance spectroscopy). The active sites (or their model structural elements) for these processes will be identified by combination of ex-situ XPS and in-situ X-ray absorption spectroscopy (EXAFS/XANES). The obtained data will be used to formulate general relationships between the oxide surface structure and composition and its electrocatalytic activity and selectivity. These general rules may be in the long run used for rational design of novel electrocatalysts with tailored properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Infinite-dimensional quantum effects' (InDiQE) targeting Horizon 2020.

assistant: **Abstract**

The fundamental understanding of quantum correlations, as well as their characterization and quantification play a fundamental role for information processing and communication. The investigation of quantum correlations in high-dimensional, infinite dimensional or hybrid systems is of particular interest for the development of novel applications in quantum technologies. High-dimensional entangled states contain a large amount of entanglement, which represents a vital resource for applications in quantum information processing. The goal of this proposal is to find an optimal strategy to exploit this resource. Crucial open problems to be solved are the continuation of the development of mathematical methods and observable conditions for a convenient description of general qudit systems, and verifying as well as quantifying general quantum correlations in high-dimensional and multipartite systems. This project is placed at the border between quantum information theory and quantum optics, exploring the potential of high and infinite dimensional systems for quantum information tasks. Additionally, modern questions in quantum thermodynamics also relate to the control of infinite dimensional quantum systems and will benefit from the methods developed. Particularly, we adapt and further develop theoretical tools to harness and efficiently describe quantum correlations in complex systems. The specific objectives are to advance the understanding of practical systems and realistic scenarios for quantum information tasks and quantumthermodynamics applications. Furthermore, the role that different kinds of quantum correlations have when complex systems are constituted of multiple degrees of freedom will be addressed. We are going to accomplish these goals by quantifying and classify
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Neutron data for waste transmutation and innovative concepts' to be submitted under Sixth Framework.

assistant: **Abstract**

Specific Objectives:The objectives listed below comprise the main objectives for 2003. However, many tasks in this action concern experiments of more than one year duration, depending on the accelerator schedule for adequate beam parameters and on the complexity of the data analysis (R-matrix fits, theory, often additional cross- check experiments):1. To improve the database of microscopic cross-sections for structural materials (EXFOR library);2. To improve the evaluated databases by state-of-the-art modelling (JEFF library);3. To obtain measurements of cross-sections for the safe handling and transmutation of radioactive waste, for Accelerator Driven Systems, for the Th- U fuel cycle and for High Temperature Reactors;4. To contribute to competence-building in nuclear physics with particular emphasis on training of undergraduate, PhD and postdoc fellows at the large- scale facilities of IRMM;5. To broaden access to GELINA and the Van de Graaff accelerator via dedicated training courses for engineers and nuclear physicists;6. To collaborate actively with research organisations in Candidate Countries via dedicated training programmes and hosting of scientists;7. To strengthen the collaboration with Member States in core areas of nuclear research of the European Community Anticipated milestones and schedule Milestones for 2003 are primarily experimental data sent to the OECD-NEA Data Bank and publications in peer-reviewed journals as follows: Publications & data submitted of I-129 & Np-237 total & capture cross sections in agreement with CEA Completion of data analysis on C-14 production on Nitrogen, report on feasibility or publication if feasible. Cross sections for Zr isotopes cross sections, publication and data submitted - Dec 2003 Cr-52, inelastic scattering, public
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Ensuring the success of the next FET Conference and exhibition at a key period for FET'.

assistant: **Innovation**

The overall objective of the FET-Event project is to efficiently support the organisation of the next edition of the FET event, addressing in particular pre-conference communication, local organisation, participant assistance, and post-conference follow-up.The 3rd edition of the FET conference and exhibition is a long-awaited one since the previous one was held in 2011 and since FET has reached a new dimension: a new mandate going beyond ICT, newly launched large-scale initiatives, and a much larger budget.In this context, the 3rd edition of the FET event has to be highly successful (over 1200 registered participants and 30 exhibiting organisations), and reach the highest impact among targeted stakeholders (researchers, policy and decision makers, innovators and entrepreneurs, educators and schools, press and media, general public)To reach these objectives, the FET-Event partners have chosen the following approach:• Maintaining a close liaison with the FET Units and the FET Advisory Group all along the project• Developing synergies with the other CSAs selected at the Call• Ensuring the full engagement of FET past and ongoing projects in the conference• Shaping a highly creative event spreading over several days (“FET Week” concept), a multi-faceted one relying on several locations in order to succeed attracting all targeted stakeholdersMoreover, the FET-Event project will evaluate the possibility for the FET event to become self-sustainable, to be organised every year / two years, still under the aegis of the European Commission and in close liaison with the FET Units but without any further grants provided through successive CSAs.The FET-Event consortium is compact and complementary. It only counts two partners offering a good knowledge of the FET programme and a longs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Enzyme Immobilization for Enhanced Transdermal Penetration of Bioactive Compounds for Treating Skin Diseases'.

assistant: **Objectives**

The use of natural bioactive compounds (NBCs) in dermatological treatment is a promising healthcare frontier, however their effectiveness is hindered by limitations in skin penetration. Enhancing their delivery to target skin layers or specific disease sites remains a significant challenge. Encapsulation of NBCs within nanodispersions (NDs) and their embedding in a biopolymer hydrogel matrix has demonstrated promising outcomes in terms of improving the delivery of NBCs through the skin. However, there's still a need for more significant enhancement in penetration, while the reasons behind this effect remain uncertain. This project aims to overcome these challenges through the immobilization of enzymes, like hyaluronidase, that breaks down hyaluronic acid (major skin component) within the biopolymer hydrogel matrix. By prioritizing enzyme immobilization as a catalyst for enhanced penetration, this project pushes the boundaries beyond traditional encapsulation methods. This project plans to extract bioactive compounds from natural sources and investigate effective biocompatible encapsulation methods. Additionally, it will assess the biopolymer hydrogel matrix where the developed NDs and enzymes will be incorporated and immobilized. The equilibrium of the immobilized enzyme will be carefully studied to achieve optimal association and dissociation, aiming to enhance transdermal delivery while maintaining skin health. Moreover, comprehensive bioavailability and cytotoxicity studies, as well as in vitro and ex vivo analyses for in depth characterization of the transdermal delivery of NBCs are planned. By merging biocatalysis and nanomaterials, this project offers a more effective alternative to conventional treatments, including skin cancer, minimizing the ecological impact.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reverse engineering of vascular patterning through mosaic in vivo analysis of endothelial cell shape regulation' (REshape).

assistant: **Innovation**

Current angiogenesis research using genetic loss-of function approaches in mouse and zebrafish models provides for a growing number of genes implicated in blood vessel formation. Mechanistic insight often remains unsatisfactory as phenotypes fall into common categories. Our recent cell competition models combined with computational analysis have transformed the way we can study mechanisms in vascular patterning.I propose to systematically exploit mosaic analysis in vivo to deconstruct vascular pattern formation in development and disease. Single differentially labelled cells in mouse and zebrafish will be analysed to establish the first catalogue of endothelial cell shapes in reference to the position and developmental phase of the plexus. Dynamic imaging will describe functional shape transitions. Advanced computational analysis of 3D-segmented cell shapes using an optimized set of shape descriptors will be performed to find natural clusters via an unsupervised expectation maximization algorithm. Cross-correlation of shape clusters with gene expression, signalling, oxygen, polarity and cytoskeleton markers will be used to understand how cell shape relates to signalling and local environment. Pharmacological and clonal genetic gain and loss-of-function will be used to analyse dynamic regulation of cell shape leading to altered vascular patterning. Mosaic analysis in retinopathy and tumour models will enable unprecedented resolution to study vascular malformation. Sequential time-lapse imaging in combination with clinical imaging modalities will be used to bridge the gap between experimental and clinical tumour vasculature imaging, enabling us to ask how local environmental changes in the tumour affect blood vessel patterning.Successful completion of this work will estab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Predicting clinical performances of cementless-hip replacements in the early stages of the design process'.

assistant: **Concept**

The aim of this project is to develop a new mixed numerical/experimental methodology in order to predict the second stability (long-term) of the cementless hip implant prior to the clinical tests. The combination of computational models together with in vitro measurements will enable -to evaluate the device attributes (such as its endurance), -to evaluate the performance of the device in vivo when subject to various physiological or pathological conditions -to carry out a complete performance evaluation and risk analysis of any new design solution prior to undertaking lengthy and extensive clinical trials. This would be particularly useful in reducing poor initial designs, which often in the past have only been noticed after clinical treatment. The development of this pre-clinical tool to assess the design evolution of new implants systems will allow a significant increase of the success rate of cementless hip implants all the patient life. Furthermore, the improved design and simulation will result also into an increased acceptance of the hip replacement and improved articulation of movements.Objectives:A wide range of skeletal diseases affects the joints of the middle-aged & older population, osteoarthritis of the hip being the most common. When conservative methods of treatment fail, it is needed to replace the affected joint with an artificial replacement called joint prosthesis. Every year more than 500 000 citizens worldwide undergo hip replacement. Total hip replacements are therefore the most important implantable orthopaedic device. Cementless hip prosthesis, the most recent type of hip prosthesis, represents today 35% of the European market. The current trend is to significant increase of its market share due to its lower failure rate that cemented hip prosthe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enabling Techniques for the Development of a Novel Class of Protein Antibiotics' to be submitted under Sixth Framework.

assistant: **Abstract**

Antibiotics resistance of pathogens is a major threat to public health and safety. The rapid spread of resistant strains increases the risk of epidemics. This issue also includes preparedness to deal with bio-terrorism. The objectives of the ET-PA project are to develop an open, generic platform to enable the development of new classes of protein-antibiotics. The key technology (REPPs) is based on a principle that is proprietary to one of the participating SMEs, consisting of rationally modified class II restriction enzymes (RE) fused to cell penetration peptide sequences (PP) that selectively allow microbial cell penetration. Introduction of a REPP system into pathogens would lead to effective cell killing. The REPP will be designed to inactivate major microbial pathogens, i.e. S. aureus, P. aeruginosa and C. Albicans. Addressing these ambitious objectives will require a Co-operative Research setup with complementing expertise and resources, coming both from high-tech SMEs and expert academic RTD partners. The ET-PA project will be divided into four work packages:1.Discovery -The design of a technology platform for the discovery of PP sequences for proper function in antibiotic REPP constructs.2.Characterization -extensive characterization of the biological activity of antibiotic REPP constructs.3.Technological platform - configuration of a semi-automatic and embedding technology platform that enables a coherent and unified approach for a rapid translation of REPP components into protein antibiotics.4.Management - to assure, consolidation and coordination of the ET-PA project, support and protection of Intellectual Property, and contacts to subsequently license the outcomes to a third-party end-user.The commitment and collective efforts of all participants is the best
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multipurpose auditory display for 3-d hearing applications' (AUDIS).

assistant: **Innovation**

In modern man-machine interfaces, the amount of visual information presented to the user has increased to such a degree that the limits of the information-processing capacity of the visual channel have been reached: in case of advanced applications or critical situations, this has introduced the risk that the visual channel is often overloaded, which may have important consequences on efficiency and safety. Given the effort spent to optimise visual displays, it is remarkable that relatively little attention has been paid to the auditory channel. In fact, the ergonomics of auditory displays is relatively poor. However the quality of these displays can be substantially improved by using techniques developed within Virtual Acoustics, which is aimed at creating realistic virtual auditory environments using sounds presented through headphones. The most relevant aspect of Virtual Acoustics is 3-dimensional sound presentation, which means creation of virtual sound sources at well-defined positions in the space around the listener. Using 3-D sound within auditory displays allows (1) directional information to be conveyed in order to support situational awareness, (2) identification of signals and voices to be facilitated by assigning them to specific spatial positions, (3) speech intelligibility and signal detection to be improved by spatially separating the sound sources. The techniques for 3-D sound presentation, that are based on accurate simulation of the acoustic effects of the environment (reflections) and of the listener's body, head and ears, have, as yet, been mainly studied in the laboratory: it is in principle possible to simulate any acoustic environment and to create virtual sound sources that can be localised with the same accuracy as actual sources. However imple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Translating molecular knowledge into early breast cancer management: building on the BIG (Breast International Group) network for improved treatment tailoring - TRANS-BIG', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

A revolution in breast cancer care is likely as we move from empirical towards molecular oncology. For Europe to lead this revolution, the Breast International Group is planning a sister" network of excellence -TRANS-BIG- dedicated to multinational translational research linked to prospective clinical trials. At the heart of TRANS-BIG is a large, non drug-oriented, molecular-based adjuvant trial for node negative patients, preceded by a validation/standardisation phase linking the genomic analysis of frozen tumour specimens to patient outcome. These exploratory and clinical studies intend, through DNA microarray gene expression, to identify patient subgroups that could be spared toxic/expensive adjuvant treatment. Such treatment tailoring for the highest incidence cancer in women might significantly decrease its economic burden. This trial aims to prospectively validate the 70-gene poor prognosis signature identified by Dutch researchers as a potentially better discriminator of outcome than traditional clinical/pathological factors. Additionally, traditional pathology analysis and bioinformatics/statistics will be centralised, contributing to standardisation/integration within the network. In light of rapidly evolving technologies, TRANS-BIG will ensure appropriate collection and storage of patient tumour/blood samples, allowing for future analysis such as proteomics and the development of user-friendly and commercially available tools in collaboration with several European SMEs. With a dedicated Ethical-Legal Committee TRANS-BIG will comply with all national/international regulations governing such research. Spreading of excellence will be achieved in partnership with Europa Donna and FECS, the latter coordinating a traineeship programme to provide opportunities for Eu