RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Neighbourhood choice, neighbourhood sorting, and neighbourhood effects'.

assistant: **Concept**

There is a strong belief among academics and policy makers that living in deprived neighbourhoods has a negative effect on residents’ life chances over and above the effect of their individual characteristics: so-called neighbourhood effects. The concept of neighbourhood effects – as an independent residential and social environment effect on individual outcomes – is academically intriguing, but has also been embraced by policy makers, mainly in connection with unemployment and a lack of social mobility. The neighbourhood effects discourse has had a major impact on urban and neighbourhood policies and has influenced governments to spend large sums of money on area based policies. A small but growing critical literature, questions the evidence base of neighbourhood effects. Although it is likely that neighbourhood effects exist, we do not know enough about the causal mechanisms which produce them, their relative importance compared to individual characteristics such as education, and under which circumstances and where these effects are important. This interdisciplinary and international proposal argues that in order to further our understanding of neighbourhood effects, and to provide a solid and sophisticated evidence base for policies aimed at deconcentrating poverty, we should investigate the effects of selection mechanisms into and out of neighbourhoods. NBHCHOICE has three objectives 1) to further develop the theoretical framework linking neighbourhood choice and neighbourhood effects 2) to empirically investigate neighbourhood choice over the life course, and 3) to integrate models of neighbourhood choice with models of neighbourhood effects. The project will use large longitudinal datasets from The Netherlands, UK and Sweden and will bring together researchers fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel DNA adductomics methodological developments for research in colon cancer' (Adductomics).

assistant: **Concept**

Covalent modCovalent modification of DNA by exogenous genotoxic molecules can translate into gene alteration, possibly inducing carcinogenesis. The analysis of DNA modifications, referred to as DNA-adducts, is fundamental for assessing the mechanism of action of genotoxic molecules. Nowadays, high resolution mass spectrometry (HRMS) is one of the most promising technique for DNA-adduct identification. Despite DNA adductomics by HRMS is highly promising, it is a new born field, presenting several analytical challenges and requiring the development of sample preparation protocols, chromatographic and mass spectrometric methods, and identification approaches. So far the majority of DNA adductomics studies were done in vitro or in animals with few studies in humans. Colorectal cancer (CRC) is considered to be highly affected by exogenous genotoxicants. Smoking, consumption of alcohol, and meat intake only explain a minor part of sporadic CRC. The mechanism of DNA modification leading to CRC has not yet been elucidated but should provide new clues about causative factors. Therefore, a DNA adductomics approach will be used in this project. Hybrid ion mobility - quadrupole - time-of-flight HRMS instrumentation will be used to develop the analytical procedures using resected colon and colon biopsies as well as urine from subjects affected by CRC or familial adenomatous polyposis (FAP), the last showing high adduct levels and very high CRC risk. High levels of DNA-adducts in FAP will increase chances of adduct identification. Urine will be used to identify DNA-adduct excretion products. The developed methods will then be used in a case-control human study with the aim of finding a correlation between specific DNA-adduct formation or specific excretion products and CRC, possibly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Past-aware material networks towards tomorrow’s textile robots' (PAST-A-BOT).

assistant: **Concept**

Textile Past-a-Bots will materialize future’s interaction interfaces between humans, other species, machines, and their environment. The foundations for this will be done by crafting active yarns into functional textile motifs, for simple sensing, computing, change in dimensions or in mechanical properties. Past-a-Bots can be dynamically assembled using these motifs, integrating the ability to detect sounds, vibrations, and proximity. The multi-sensorial functionalities allow for an ecocentric approach by combining dominant sensing pathways of diverse species.In PAST-A-BOT, desired functionalities emerge from the intricate and interdependent optimization of chosen materials, yarn structures and textile motifs, elucidating the hierarchical construction of functional textiles. As a highlight, we aim to build a simple logic data processing unit by combining twist-coiled polymer actuators, synthesized from bio-sourced materials, with an interlaced structure. Moreover, this can be combined to motifs of new textile-based broad-band acoustic sensing or actuators allowing large dimensional change. Thus, Past-a-Bots will reframe textiles as modular networks with varying optimized functionalities responding to the local situations.PAST-A-BOT demonstrates an interdisciplinary research strategy by corresponding with (i) collective vast knowledge of past textile crafts and (ii) envisioned alternative futures enabled by new materials and functionalities. The scenarios based on the dialogue between past and future iteratively guide the optimization of these textile units as building blocks for tomorrow’s applications. They range from soft highly deformable rescue robots to sound-sensing point-of-care agrofabrics and voice-controllable assistive clothing. The developed open-source tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '10th meeting of directors of fisheries EU research organisations' in the context of a Fifth Framework call.

assistant: **Objectives**

Coinciding with the Portuguese Presidency, it was decided to hold the 10th meeting of Directors of Fishery Research Organisations. The main purpose of this meeting is to continue the co-ordination of the National research programmes with the EU Fifth Framework Programme for research in the field of fisheries and aquaculture. During the meeting, problems in fisheries research will be discussed among Directors of research Institutes, Commission and Industry, in order to contribute to the development and implementation of the EU-Common Fisheries Policy.Against this background the following topics will be discussed:I- Review of the state of fisheries research within the EU, taking into consideration:a- present and foreseeable situation with the biological, social and economic studies, and other related fields within DG XIV including support for data collection, mainly in terms of fisheries policy and new regulatory framework
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural biology of mammalian transcription regulation' (TRANSREGULON).

assistant: **Concept**

The regulation of gene transcription by RNA polymerase (Pol) II underlies cell differentiation and organism development, and its dysregulation causes many cancers. Transcription regulation occurs during initiation, when Pol II assembles with initiation factors on promoter DNA, but also during mRNA chain elongation, when Pol II pauses near the promoter before it restarts upon activation. Our previous ERC Advanced Grant ‘TRANSIT’ enabled us to provide molecular insights into yeast Pol II initiation and its regulation by the Mediator coactivator complex (Plaschka et al., Nature 2015; Sainsbury et al., Nature 2012, Lariviere et al, Nature 2012). Here, with our new proposal ‘TRANSREGULON’ we wish to open a new frontier and provide the structural basis for mammalian Pol II regulation during elongation. We will use an integrated structural biology approach combining X-ray crystallography, cryo-electron microscopy, and crosslinking, to obtain the first atomic structure of a mammalian Pol II enzyme (aim 1), the structure of the negative elongation factor NELF (aim 2), which is required for promoter-proximal pausing by mammalian Pol II, and the threedimensional architecture of the promoter-proximally paused Pol II complex (aim 3) containing the multiprotein pausing factors NELF and DSIF, and eventually also the pause release factor p-TEFb. This ground-breaking work will make the transition from yeast to human structural biology of transcription, will provide the molecular basis for a central mechanism of cellular regulation, and will advance structural biology methods for dissecting large and transient mammalian multicomponent complexes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Semiconductor Spintronics: Spin Polarisation and Nanodevices', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The proposed research programme addresses important issues in the field of ferromagnetic semiconductor spintronics which are of fundamental and potential technological importance. At the core of the project are the objectives of measuring the carrier spin polarisation in ferromagnetic semiconductors (a key quantity for spintronics) and of producing nanoscale ferromagnetic semiconductor single electron transistors which promise new spintronic functionalities. The applicant and the host Semiconductor Spintronics Group are uniquely matched to make this timely and important project possible. The applicant is an expert in the field of superconductivity and its interplay with magnetism who has extensive experience of focused ion beam nano-patterning and Point Contact Andreev Reflection spectroscopy, which makes possible the measurement of spin polarisation. The host Semiconductor Spintronics Group are internationally-leading in the field of ferromagnetic semiconductor materials and device development. This research project is very complementary to, but clearly differentiated from, existing research projects at Nottingham. In essence the intention is for the applicant to apply her particular expertise and techniques to materials fabricated at Nottingham for the realisation of important advances in semiconductor spintronics, thus greatly benefiting applicant and host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploring the microbiome-mediated resilience of intercropping to more persistent precipitation regimes' (MiBioCrop), addressing dissemination and exploitation.

assistant: **Impact**

Persistent precipitation regimes (PRs) characterized by frequent wet and dry spells can severely disrupt crop production by alternating patterns of drought and waterlogging stresses, posing a serious threat to future food security. In the MiBioCrop project, I aimed to explore the potential of a classical cereal/legume intercropping (IC) system (i.e., wheat/pea) as a PR-resilient cropping system and test if such resilience is mediated by IC-induced shift in wheat rhizosphere microbiome. To achieve its main objectives, MiBioCrop will be implemented through three work packages (WPs) comprising 28 specific tasks, covering both research activities and an extensive communication and dissemination strategy. In WP1, I will expose wheat monoculture and intercropped plants to different PRs under ambient or elevated atmospheric temperature in the Free Air Temperature Increase (FATI) facility. Besides measuring crop yield, soil nutritional profile, soil denitrification activity, and nitrous oxide accumulation, I will use next-generation sequencing to study the wheat rhizosphere microbiome comprehensively. To study plant stress responses to PR during IC, I will use metabolomics, transcriptomics and quantitative PCR in WP2. In WP3, I will validate the microbial role in wheat productivity by using wheat rhizosphere soil from WP1 as soil inoculum and studying wheat yield and plant responses using transcriptomics and quantitative PCR in another FATI experiment under PRs. These results will enhance our understanding of the dynamics of plant-interspecific interaction, the role of rhizosphere microbiome in plant health under PRs, and the effectiveness of legume-based intercropping as a PR-resilient cropping system. This knowledge may be used for the development of sustainable agroecosystem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Tuning the brain for music'.

assistant: **Concept**

BrainTuning project is devoted to resolve the neural determinants of music emotions and appreciation. This topic is approached in a synergetic, multidisciplinary fashion by taking into account the neurocognitive determinants and development of music emotion and appreciation in various subject groups, from infancy to mature adulthood. Both musically untrained as well as musically highly sophisticated people will be investigated. The project will utilize the following up-to-date methods of human cognitive and affective neuroscience: high-resolution electroencephalogram (EEG) and magnetoencephalogram (MEG) for adult and children recordings, functional and anatomical magnetic resonance imaging (fMRI; MRI), and transcranial magnetic stimulation (TMS). The project involves all leading experts of the field: University of Helsinki, Department of Psychology (Drs. Tervaniemi and Huotilainen) as the coordinator and Universities of Jyväskylä (Finland), Vita-Salute San Raffaele University, Milan (Italy), Leipzig (Germany), and Montreal (Canada), as well as Kungliga Tekniska Högskolan (Royal Academy of Technology, Stockholm; Sweden) as its partners. By these means and personnel, the project will explore:* the neural basis of music emotions and appreciation * the objective basis for music therapy. Jointly, the project achievements will lay solid basis for new field of science, affective neuroscience of music.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'One Network for Europe'.

assistant: **Innovation**

While the electrical grid is moving from being a fully centralized to a highly decentralized system, grid operators have to change their operative business to accommodate for faster reactions and adaptive exploitation of flexibility. The topic has been subject of several research projects in the past years and reached a maturity that allows now the consideration of a final level, proposing an integrated view on the grid operations beyond the traditional barriers. OneNet aims at performing this critical step creating the conditions for a new generation of grid services able to fully exploit demand response, storage and distributed generation while creating fair, transparent and open conditions for the consumer. As result, while creating one network of Europe, the project aims to build a customer centric approach to grid operation. This ambitious view is achieved by proposing new markets, products and services and by creating a unique IT architecture. While a single platform for Europe is not thinkable, OneNet proposes innovative mechanisms of platform federation which are the key technical enablers for the proposed vision. The project has also very ambitious exploitation goals aiming at creating consensus on the solution far beyond the limits of the consortium partners thanks to a variety of actions including a large-scale forum for discussion within the international energy community. The complete concept is also proven in 4 cluster demos creating an involvement of an unprecedented number of countries and their grid operators in a single project.  The consortium, in addition to a significant list of grid operators, includes also key IT players, leading research institutions and the two most relevant associations for grid operators, jointly providing a unique set of expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The world’s most efficient heat engine: Turning heat into zero-emission electricity for industrial and geothermal applications'.

assistant: **Objectives**

At Luminescent we specialise in proprietary liquid-based isothermal heat engine technology, a disruptive innovation in the renewable energy sector. Our Lava heat engine is designed to harness a wide range of thermal energy from various industrial processes and turn it into a valuable commodity: electricity. This innovative approach not only elevates  the efficiency of industrial operations  but also contributes significantly to sustainability by generating clean, green power from untapped heat sources.


**Keywords:** heat engine, renewable energy, geothermal energy, electricity, carnot efficiency
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Species Identity and SYmbiosis Formally and Experimentally explored' in the context of a Seventh Framework call.

assistant: **Objectives**

Symbiosis is described as a close relationship between different biological species. It is a pervasive phenomenon, often of a long term nature. It has been estimated that 50% of all known species are parasites, i.e. maintain a symbiotic relation with another species from which they benefit while the partner in the relation is harmed, and that close to a 100% of all plants and animals are parasitised as individuals. Indeed, there are thought to be 10 times more bacterial cells in a human body than human cells. There is growing recognition that symbiosis has a profound impact on the origin and maintenance of the biome and of its ecosystems, on the health of living organisms, and even on sex! Symbiosis thus appears essential to understand some of the most fundamental evolutionary and functional questions related to living organisms. Nevertheless, although symbiotic relationships have been studied by biologists since the early 19th century, they remain little explored by computational biologists. Yet, investigating the enormous variety of such relationships raises formidable mathematical and computational issues. By a highly pluri-disciplinary approach that blends mathematics, algorithmics and wet-lab experiments, we propose to do an intensive, large-scale exploration of the huge variety of genomic and biochemical landscapes observed in the symbiont world, at the interface between symbionts and hosts, and of both with their environment. Our objective is to arrive at a clear view of the importance of symbiosis. This could have far-fetched theoretical and practical implications, notably on our notions of health, our relation with our environment, and our idea of what is species identity, including our idea of what is an individual .