RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Roles of mitochondria in healthy and diseased myelin' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Demyelinating peripheral neuropathies form a diverse group of pathologies that include diabetic and aging peripheral neuropathies and inherited Charcot-Marie-Tooth diseases. Mitochondrial dysfunctions have recently emerged as one major cause for these diseases. The goal of this project is to investigate the role of mitochondria in healthy and diseased myelin and to test whether we can change mitochondrial status and functions to prevent or treat these diseases. Our working hypothesis is that glial mitochondria act as a homeostatic interface between axon and glia: they participate to the destabilization of Schwann cells during demyelination and they help to detoxify axons by scavenging reactive oxygen species produced by axonal mitochondria. We have developed a novel approach that uses viral vectors to express cDNAs and/or small inhibitory RNAs in myelinating Schwann cells and myelinated axons in mice in vivo. I propose to use this approach combined with state-of-the-art imaging technique to challenge this preliminary concept in a meaningful in vivo context. Viral tools will first be used to generate defects in mitochondrial functions in the myelinating Schwann cell. The impact on myelination and myelin maintenance will be assessed by light and electron microscopy. Second, viruses will be used to express genetically-encoded fluorescent probes designed to analyze mitochondrial status in living cells. This imaging approach will allow investigating mitochondrial status in healthy, demyelinating and diseased myelinating Schwann cells in vivo. Finally we will investigate the impact of glial mitochondria dysfunctions on the axon. Reversely we will also modify axonal mitochondria and check the impact of these changes on myelin and glial mitochondria. This concept will be highly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Science and policy integration for coastal System Assessment' (SPICOSA) under Sixth Framework.

assistant: **Objectives**

The overall objective of SPICOSA is to develop a self-evolving, holistic research approach for integrated assessment of Coastal Systems so that the best available scientific knowledge can be mobilized to support deliberative and decision-making processes aimed at improving the sustainability of Coastal Systems by implementing Integrated Coastal Zone Management (ICZM) policies.Based on a system approach, a multidisciplinary assessment framework will be developed with a balanced consideration of the Ecological, Social and Economic sectors (ESE) of Coastal Systems. This System Approach Framework (SAF) will be used to explore the dynamics of Coastal-Zone Systems and potential consequences of alternative policy scenarios. Achieving this objective will require a restructuring of the science needed to understand the interactions between complex natural and social systems at different spatial and temporal scales including the overall economic evaluation of alternative policies.Furthermore, SPICOSA will contribute to a more integrated science-policy interface, i.e. specifically by developing and testing deliberation support tools for the transfer scientific products to policy decision-makers, stakeholders, and end-users. The SAF and its tools will be implemented in eighteen coastal Study Site Applications, which range from Norway to Portugal to Turkey and to Romania, A SAF Portfolio consisting of generic assessment methodologies, specific tools, models, and new knowledge useful for ICZM, will be produced in a manner that is user-friendly and updateable for future CZ researchers and professionals.In addition, SPICOSA will generate new curricula, training modules, and training opportunities for academics and professionals involved in Sustainability Science and ICZM implementation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Centre of excellence in development of new therapeutics from sugars' in the context of a Fifth Framework call.

assistant: **Objectives**

Establishing the Centre of Excellence in Developments of New Therapeutics from Sugars (CEDNETS) at the Institute of Organic Chemistry, Polish Academy of Sciences is the most appealing task. Three research groups (headed by Prof. S. Jars, J. Jurczak, M. Chmielewski) will be engaged in CEDNETS. With Prof. Jars being the coordinator. The I.O.C., PAS already has good experience in preparation of the optically pure compounds from sugars CEDNETS, being a part of this top scientific Institute, will work on further development of methodologies leading to optically pure drugs. CEDNETS will cooperate with other scientific units in Poland and abroad (especially those from the EU) and will integrate Polish researchers (especially these from CEDNETS) with the scientific community in Europe. Execution by five work packages: 1 - Workshops, 2 - Ph.D. Studies, 3 - Building a capacity of the Centre, 4 - promotion, 5 - Coordination of the Centre.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'detailed 3D Building models Automatically Generated for very large areas' to be submitted under Horizon Europe.

assistant: **Abstract**

In the ERC project Urban Modelling in higher dimensions (UMnD) we developed a solution for detailed 3D Building models Automatically Generated for very large areas (3DBAG). This prototype was applied to generate detailed 3D models for all 10 million buildings in The Netherlands. Such a digital twin of built objects provides a valuable data source and simulation basis for professionals working in planning, design, construction, energy, real estate, as well as for environmental impact studies on noise, floodings, wind flows, air quality and urban heat islands. 3D models are already used in specific domains, but it takes a lot of effort to generate suitable 3D building models for a given application due to the required manual editing. Therefore, detailed 3D models are rarely available for large areas (regions or nations). The solution lies in the unique method we developed, which enables to generate high-quality, easy-to-use 3D building models fully automatically at national scale to be used without any technical or legal restriction. This will be a breakthrough for the use of 3D data in current and new applications. With the beta-release of the Dutch 3DBAG and the subsequent wide adoption and application of it by industry and government, the effectiveness of 3DBAG has been demonstrated. This PoC aims to further advance 3DBAG from the current TRL6 to TRL9. Firstly, we will make 3DBAG technically sustainable by addressing issues to achieve even higher adoption, supporting more height data sources as available in other countries and to prepare for the maintainability and performance of our method in an operational setting. Secondly, we will explore how to best ensure the economical sustainability of 3DBAG by clarifying the IPR and licencing strategy and assessing the market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Automated Anode Fork Repair System for the Aluminium Rodding Plant'.

assistant: **Objectives**

Worn out anode forks from aggressive alumina smelting conditions require efficient repair processes since they contribute around 16% of the heat lost during electrolysis. Currently, most of the repair is handled manually, giving room for human error, inconsistencies and high labour costs. There is also a high carbon footprint from the manual propane cutting and transportation of forks to a distant rodding plant. The concept of our project, Auto-Anode, hinges on integrating automated anode repair modules, and at least doubling the speed, accuracy, efficiency, safety and accountability of the process. It will eliminate propane use and the need to transport forks to a separate workshop, thereby reducing the carbon footprint by ca 48t CO2 pa. Automation for the various stages has largely been validated. The challenge lies now in ruggedising the machine vision and integrating the system. Undoubtedly, a properly integrated Auto-Anode system will be a game changer for the aluminium smelters, with yearly savings of up to €30 per ton of produced aluminium, and for our company, generating an accumulated net profit of €21.65 million by 2024. Besides compound savings by smelters, Europe could save up to €4.5million from potential imports of aluminium and give an edge in the lightweight automotive race, while cutting on greenhouse emissions.  Imminently, SMEs within the value chain can enjoy increased profitability since the price of locally produced aluminium will be lower. Global savings of up €13million pa are possible due to the use of Auto-Anode. To ensure a widespread uptake of this advanced process technology, beyond assuring technical, seamless excellence, we will carry out a detailed market study; conduct a technology watch and IPR strategy; consolidate supply chain partner
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Scalable Quantum Photonics with Ultra Bright Photon Sources' (SQuaPh).

assistant: **Innovation**

The development of quantum networks relies on true single-photon sources and deterministic quantum logic gates. Photons are the most promising flying qubits, capable to propagate long distances without decoherence. However, until now, quantum communications protocols and optical quantum computation have been implemented using defective single-photon sources and probabilistic quantum gates. For a long time, the best single-photon sources have been heralded non-linear crystals where photon-pairs are generated. Such sources can present high coherence properties although they are intrinsically limited to a very low photon flux.This project builds up on major steps obtained in the host team, Laboratoire de Photonique et de Nanostructures, in terms of true single-photon generation and control. By deterministically inserting a quantum dot (QD) in a semiconductor microcavity pillar, the host team fabricated photon sources with quantum properties as good as the currently used sources, but with an unprecedented brightness of 2 orders of magnitude larger. The cavity not only enhances the interaction of the incident photons with the QD state but also the subsequent photon extraction of the device. The Purcell effect diminishes the decoherence processes, constituting an ultrabright source of highly indistinguishable, single-photons.Based on the unique technological, experimental and conceptual knowledge developed by the host team, and on the background of the applicant, our successive objectives is to realize scalable quantum entanglement: to entangle two-photon states with our ultrabright QD-cavity systems at high rates, to use them to perform high fidelity teleportation with long coherence times between 2 different sources, and finally to controllably swap the entanglement between
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A biological network approach to the study of biochemical origins, early cellular evolution, and gene distributions across genomes' (NETWORKORIGINS).

assistant: **Innovation**

The further back we look in time, the less we know about the course of life's history. Genomics, through phylogenomics, will eventually resolve the evolution of macroscopic life, whose phylogeny can be properly modeled in the mathematical image of a bifurcating tree; where the evolutionary process is fundamentally tree-like in nature, we only have to collect enough data to bring the structure of the tree into focus. But when we look back into the evolution of microscopic life and early evolution   that is, prokaryotic evolution, the prokaryote-to-eukaryote transition, and the origin of life   genome sequences are only of limited help. That is because neither the evolutionary process linking the evolution of genes across prokaryotic genomes nor the process linking prokaryotes to eukaryotes is strictly tree-like in nature. In prokaryote genome evolution, lateral gene transfer (LGT) is an important mechanism of natural variation, while the prokaryote-to-eukaryote transition involved the wholesale merger of prokaryotic genomes via endosymbiosis. This proposal aims to deliver a quantum advance in our understanding of early evolution. Prokaryotic genome evolution and the prokaryote-to-eukaryote transition will be investigated with mathematical tools that better approximate the process as it occurs in nature, by using the graph theoretical tools of networks rather than that of trees. For understanding the origin of life, genome data is inapplicable, because genes cannot be compared to inorganic compounds from which life ultimately arose. When it comes to linking microbial life to geochemical processes, the comparison of chemical reaction sequences in living things to those geochemistry is all with which we have to work. Some forms of hydrothermal vents harbour newly discovered
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Numerical characterisation of fire growth in external facades and other vertical spaces' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Fire growth through spreading up the façade of high-rise buildings can lead to catastrophic loss of life and property. Façades at times are required to have a fire-resistance rating, for instance, if two buildings are very close together, to lower the likelihood of fire spreading from one building to another. The issue is becoming increasingly critical due to new development trends involving higher buildings and sometime in close proximity to each other and the increasing use of combustible material in façade to raise energy performance of buildings. The proposed Fellowship is aimed at investigating numerically the behaviour of flames ejected from enclosure fires in external facades and other vertical spaces such as atrium, void spaces and staircases. Full understanding of such external flame behaviour requires insight of the combustion processes within the enclosure. Hence the scope of the research includes enclosure fires to characterise the ejected flames as well as fire growth in façades. The research will take advantage of the abundant experimental data available for model validation.  The specific objectives include: 1. Fine tune and validate the open source CFD code FireFOAM , a dedicated LES based solver for fire simulation within the OpenFOAM® toolbox for enclosure fires; 2. Investigate the combustion and aerothermodynamics of enclosure fires, including travelling fires; 3. Characterise the spill flame extent, combustion efficiency and heat fluxes inside and outside different enclosures with different openings (office blocks, residential buildings, travelling fires in open plan compartments, etc.);4. Develop and validate a predictive approach based on FireFOAM for façade fires; 5. Conduct parametric studies for different façade panel materials, spread upwards/d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ultra-sensitive NMR in liquids' to be submitted under Horizon 2020.

assistant: **Abstract**

The nuclear magnetic resonance spectroscopy (NMR) is a versatile and powerful tool, especially in chemistry and in biology. However, its limited sensitivity and small amount of suitable probe nuclei pose severe constraints on the systems that may be explored.This project aims at overcoming the above limitations by giving NMR an ultra-high sensitivity and by enlarging the NMR ""toolbox"" to dozens of nuclei across the periodic table. This will be achieved by applying the β-NMR method to the soft matter samples. The method relies on anisotropic emission of β particles in the decay of highly spin-polarized nuclei. This feature results in 10 orders of magnitude more sensitivity compared to conventional NMR and makes it applicable to elements which are otherwise difficult to investigate spectroscopically. β-NMR has been successfully applied in nuclear physics and material science in solid samples and high-vacuum environments, but never before to liquid samples placed in atmospheric pressure. With this novel approach I want to create a new universal and extremely sensitive tool to study various problems in biochemistry.The first questions which I envisage addressing with this ground-breaking and versatile method concern the interaction of essential metal ions, which are spectroscopically silent in most techniques, Mg2+, Cu+, and Zn2+, with proteins and nucleic acids. The importance of these studies is well motivated by the fact that half of the proteins in our human body contain metal ions, but their interaction mechanism and factors influencing it are still not fully understood. In this respect NMR spectroscopy is of great help: it provides information on the structure, dynamics, and chemical properties of the metal complexes, by revealing the coordination number, oxidation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Logarithmic conformal field theory as a duality between Brauer-type algebras and quantum groups at roots of unity'.

assistant: **Concept**

This project concerns the little studied  class of  logarithmic two-dimensional conformal field theories (LCFTs) - with  unusual properties such as non-unitarity and non-semisimplicity. LCFTs  have applications in   statistical mechanics (sand-piles, percolation,  polymers, disordered electrons) and in  the AdS/CFT conjecture. They have come under increased interest in the mathematical physics community . Yet,  very few LCFTs have been understood at  the writing of this proposal, and the subject is still in its infancy.LCFTs involve difficult mathematical aspects, and  bear a resemblance to non semi-simple Lie algebras. Their study involves such problems as the  description of non-semisimple (modular) braided tensor categories of modules over vertex-operator algebras (VOAs), as well as  representation theory of affine Hecke algebras and quantum groups at `roots of unity'.We propose to bridge and further develop two recent  promising approaches. One - put forward by the  applicant - uses a new, mathematical, description of LCFTs based on VOAs, screening operators and ribbon Hopf algebras. The other, pioneered by the host, uses a  more physical approach based on explicit lattice regularizations, and  study of the corresponding lattice algebras. Both rely on similar mathematical structures, such as quantum groups, bimodules over mutual centralizers,  non-semisimple tensor categories, and Morita equivalence. It is hoped that, by bridging the two approaches, several goals will be reached. On the mathematical side, these include better understanding and  classification of  indecomposable modules  for chiral algebras in LCFTs, better understanding and definition of the  scaling limit, and  reconstruction of  non chiral LCFTs from their chiral counterparts. On the  physical sid