RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CIDNP study of photochemically generated short lived radical intermediates of biologically important molecules' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The project is aimed at the application and further development of a novel non-destructive NMR method of high sensitivity, chemical selectivity, and high spectral resolution. The method is based on chemically induced dynamic nuclear polarization (CIDNP) for studying the structure and dynamic processes of biological macromolecules at physiological conditions.We propose to utilize the nuclear spin polarization that is formed in the reversible light-induced radical reactions of dye markers with proteins and nucleic acids and their structural subunits (amino acids, peptides, nucleotides, oligonucleotides) in aqueous solution and to expand the application of the method to similar processes in the solid state.The research methodology includes application of three types of CIDNP experiments:- with time-resolution,- with magnetic field variation by field-cycling, and- with resonant pumping of electronic spin transitions for NMR detection of EPR spectra of spin correlated radicals pairs in combination with field-cycling.The project has an interdisciplinary character and includes biological, photochemical, and physical approaches.The research activities are associated with the following:- The study of photochemical reactions involving proteins and protein-related molecules will create a reliable basis for studying proteins using the CIDNP technique, and will contribute to the knowledge of photochemistry of biopolymers.- The investigation of native, partially folded and denatured states of proteins, as well as the study of the processes of denaturation and folding will be compared with the theoretical modeling of protein dynamics.- Development and application of MAS-NMR detection of time evolution and field dependence of nuclear polarization in proteins in solid state.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Novel biodegradable, REcyclable, BIO-based and safe plastic polymers with enhanced circuLar properties for food packaging and agricUltural applicaTIONs'.

assistant: **Objectives**

Plastic waste poses an important environmental problem in Europe and worldwide, especially from leakage to natural habitats. Of more than 29 Mt of plastic post-consumer waste collected in the EU in 2020, the average recycling rate of packaging waste was less than 40%. Packaging is the largest end-use market of plastic demand (40.5%). Multilayer packaging (e.g. paper/plastic composites), widely used in the food and beverage industry, applies mostly polyethylene (PE) film as plastic coating. In the agriculture sector, plastics are used to enhance crop yield, save water and agrochemicals but bear the risk of being lost during operation. Agricultural plastics market represents 3.2% of the plastic demand and the 50% increase in global food supplies expected by 2050 will lead to a substantially higher demand of plastics for mulch films (today mainly made of PE).REBIOLUTION aims to design and synthetize novel fully bio-based and biodegradable polyester blends based on 2,5-Furandicarboxylic acid (FDCA) and other bio-based monomers fit for specific product-market applications selected in this project for their widespread use and negative impact on the environment: (1) plastic coating for food packaging (e.g. for frozen/chilled food or ready meal trays) and (2) mulch films for agricultural applications.Well-defined properties will be established by carefully tuning the polymer blends for each application in order to boost the sustainability performance (non-toxic substances used, reduced non-renewable energy consumption, recyclable and at the same time home compostable and biodegradable in soil and aquatic environments) and improved functionality while ensuring product and processes safety. REBIOLUTION is committed to remove barriers to market penetration by providing a drop-in b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative catalysts to produce cleaner diesel fuels' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content Objectives and content Our objectives are the synthesis and development of new catalyst materials, which would contribute to the production of cleaner diesel fuel in two ways  by upgrading the polyaromatics components of light cycle oil to linear and branched paraffins of higher cetane number by hydrogenation and ring opening reactions  by the production of synthetic diesel components using low-value light olefin raw materials. The catalysts developed will incorporate acid sites of controllable strength (for ring opening and oligomerisation) and transition metal centres (for hydrogenation). Two families of materials will be developed:  pillared layered solids, in particular pillared phosphates, synthetic and natural clays; acid and transition metal sites may both be within the pillaring fragment, or the acid site only may be in the pillar and the transition metal at intrapore sites  mesoporous oxides and phosphates having a uniform, hexagonal arrangement of pores, prepared by surfactant templating routes. These types of material span a pore diameter from ca. 10 - 50 A, i.e. beyond that of conventional vaporous zeolites. Compounds prepared will be characterised using a range of structural, thermal, spectroscopic and surface analytical techniques. They will be screened for the nature and strength of their acid sites, for their ability to fully hydrogenate polyaromatics and to decyclise saturated polyaromatics. They will be tested on synthetic mixtures and on real feedstocks at the bench-scale by two of the industrial partners. The synthesis of the most successful materials will be scaled-up by the third industrial partner. No catalysts are commercially available for the targeted processes, and yet there are clear strategic reasons for satisfying the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Aberrant RNA degradation in T-cell leukemia' (ART) targeting Seventh Framework.

assistant: **Abstract**

The deregulation of transcription is an important driver of leukemia development. Typically, transcription in leukemia cells is altered by the ectopic expression of transcription factors, by modulation of signaling pathways or by epigenetic changes. In addition to these factors that affect the production of RNAs, also changes in the processing of RNA (its splicing, transport and decay) may contribute to determine steady-state RNA levels in leukemia cells. Indeed, acquired mutations in various genes encoding RNA splice factors have recently been identified in myeloid leukemias and in chronic lymphocytic leukemia. In our study of T-cell acute lymphoblastic leukemia (T-ALL), we have identified mutations in RNA decay factors, including mutations in CNOT3, a protein believed to function in deadenylation of mRNA. It remains, however, unclear how mutations in RNA processing can contribute to the development of leukemia.In this project, we aim to further characterize the mechanisms of RNA regulation in T-cell acute lymphoblastic leukemia (T-ALL) to obtain insight in the interplay between RNA generation and RNA decay and its role in leukemia development. We will study RNA decay in human T-ALL cells and mouse models of T-ALL, with the aim to identify the molecular consequences that contribute to leukemia development. We will use new technologies such as RNA-sequencing in combination with bromouridine labeling of RNA to measure RNA transcription and decay rates in a transcriptome wide manner allowing unbiased discoveries. These studies will be complemented with screens in Drosophila melanogaster using an established eye cancer model, previously also successfully used for the studies of T-ALL oncogenes.This study will contribute to our understanding of the pathogenesis of T-ALL and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Messina Case: Mafia-type Organised Crime in the Province of Messina' to be submitted under Horizon 2020.

assistant: **Abstract**

The 2013 Europol Threat Assessment concerning Italian organised crime outlines how the ongoing threat that mafias pose to the EU is ‘unparalleled by any other European Organised Crime Group’. Significant successes in judicial investigations have undoubtedly contributed to a better understanding of Italian mafias over time. However, the emergence and expansion of mafia groups in non-traditional areas of settlement leave aspects of the phenomenon still unexplored. This is the case of the Sicilian mafia in the province of Messina which, despite being the object of parliamentary inquiries, court cases, and increasing media attention, has largely been neglected by scholarly literature. The proposed research aims to fill this gap. Adopting an interdisciplinary approach, this project aims to trace the history and evolution of mafia groups in the province of Messina –what the judiciary refers to as ‘The Messina Case’– examining their structure, ethos and modus operandi. It will be conducted using a qualitative methodological framework within the interpretive tradition and will involve the analysis of legal documents and judicial papers, in-depth interviews with judicial and police authorities, and state witnesses. Such an interdisciplinary approach allows us to delineate the evolution and structure of mafia groups, their external and internal relations and flux of power, as well as the role that shared cultural values and social conventions play in the dynamics of identity formation. By identifying the components that the mafia in the province of Messina shares with traditional mafia groups in Sicily and Calabria whilst simultaneously exposing a unique reality, this project will advance current research into mafia expansion in non-traditional areas. Through a number of research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advancing mEasures to Reduce aviatiOn imPact on cLimate and enhAnce resilieNce to climate-changE' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The interconnection between Aviation and climate is very tight. On the one hand, air traffic contributes to greenhouse gas emissions that alter the composition of the atmosphere globally, hence driving Climate Change. On the other hand, atmospheric processes significantly impact the whole chain of Aviation: changes in temperature affect infrastructure and aircraft performance, variable wind and precipitation patterns increase delays and cancellations, etc. In recent years, researchers put a strong effort in investigating the impact of Aviation on climate and ways to mitigate it. Putting these knowledge advancements into practice requires further development of the climate impact assessment methodology towards the deployment and implementation phases. In addition to these efforts, new adaptation measures are necessary to make the aviation sector less vulnerable to the unavoidable changes in climate conditions which we are already experiencing, such as heatwaves and other highly-impactful weather phenomena.Objectives: The project aims at developing a toolset for reducing the aviation impact on climate and to enhance the sectors resilience to climate change. The idea is to advance the knowledge and operationalize the monitoring on the impact of aviation on climate, and, concurrently, to assess the resilience of the aviation sector to the exacerbation of extreme events due to climate change.


**Keywords:** Climate Change, Mitigation, Adaptation, Climate Metrics, CO2 and non-CO2 effects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FEED your mind: Investigating the nature, ontogeny and evolution of cognitive processes underlying food behaviors, to pave a way toward efficient interventions promoting healthy eating in early life' under Horizon Europe.

assistant: **Concept**

The rise of food-related health disorders calls for action. Food behaviors take shape early in life and track well into adulthood. Thus, efficient evidence-based interventions promoting healthy food practices in early life are key to tackling these challenges. The aim of the project is to shed light on the cognitive processes underlying food learning in infancy and provide empirical bases to design such interventions.The project adopts a novel perspective on food learning. Current research has overlooked that our modern food environment strongly differs from the environment in which our ancestors lived. In fact, in most cultures today, decisions about food are made during a trip to the grocery store, where we might ask ourselves: Are these canned tomatoes healthy? but certainly not: Are they edible or toxic?. As a result, scholars missed that a critical step in learning what to eat over the course of ontogeny, is determining which entities in the world are wholesome foods and which ones are harmful items to eschew. The project will fill this research gap using robust methods from neuroscience and psychology. First, WP1 will investigate the ontogeny and neuro-cognitive bases of the capacity to recognize food objects, testing whether this capacity emerges when infants transition to solid food, guiding their attention to food-relevant inputs, such as social information about edibility. Second, WP2 will examine the social component of food learning processes, once infants are able to recognize food objects, testing whether infants show a negativity bias when learning about food from others, giving more weight to negative than to positive information. Finally, building on WP1 and WP2 results, WP3 will investigate the longitudinal relationship between the processes underlying
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification and characterization of genes and promoter elements involved in the regulation of seed germination' to be submitted under Sixth Framework.

assistant: **Abstract**

Seed biology is crucial to improve the nutritional value of agronomically important seeds. While seed development has been extensively studied, very little is known about the process by which the embryo emerges from the seed to complete germination. This project is aimed to a better understanding of the molecular mechanisms that control germination by identifying and characterizing key regulatory genes and conserved promoter cis-elements. Data from global gene expression analysis (micro-arrays) in the model plant Arabidopsis thaliana will be analysed to identify genes induced specifically upon germination and putatively involved in different key aspects of germination. For selected genes we will isolate the promoters of their orthologous genes in other plant species from within and outside the Brasicaceae family.We will compare those promoters and perform in silico analysis to identify conserved motifs, which will be strong candidates to be functionally important cis-sequences. Identified sequences will be characterized in vivo and those being transcriptionally active will be used in a yeast one-hybrid screening with a normalized expression library containing approx. 75% of Arabidopsis transcription factors (TFs). The identified TFs will be subjected to functional analysis using reverse genetic approaches. The results from this research will abound in the complex mechanisms underlying seed germination and possibly in other intimately linked seed processes such as seed development and dormancy. The knowledge generated may benefit the crop industry by helping enhance plant fitness and by providing valuable molecular markers to use in marker- assisted breeding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The role of Von Willebrand Domain-containing Protein 8 in mitochondrial physiology'.

assistant: **Innovation**

Mitobetes project brings a new research on poorly characterized mitochondrial protein involved in important cellular andphysiological processes such diabetes, kidney failure and cancer. It also aims on the role of mitochondria in diabetes, thedisease which affects almost 10% of European population. The mitobetes project has a potential to help to find a newmitochondrial protein involved in diabetes, find a mechanism of diabetes development, increase the public knowledge aboutdiabetes and thus helps to decrease EU healthcare costs.Mitochondria are crucial organelles not only in energy conversion, but also in a plethora of other biological processes. Theirfunction is closely related to their dynamics, controlled by the pro-fusion proteins Mitofusin (Mfn) 1 and 2 and Optic atrophy 1(Opa1); and by the fission proteins mitochondrial fission factor (Mff) and dynamin related protein 1 (Drp1). Opa1 not onlycontrols mitochondrial fusion, but also shape of the mitochondrial cristae, a crucial parameter in determining mitochondrialfunction and participation in apoptosis. Opa1 exists in high molecular weight complexes of unknown composition that aredynamically modulated during cristae remodeling.Recently, the host laboratory completed a proteomic catalogue of proteins associating with Opa1 in intact cristae and leavingthe complex only when cristae shape was disrupted. Among the hits associating with Opa1, the host lab discovered VonWillebrand Domain-containing Protein 8 (Vwa8), a mitochondrial protein of unknown function whose higher levels correlatewith worse prognosis of Acute Myeloid Leukemia (AML). Here, I propose to understand the function of Vwa8 in mitochondrialnetwork and cristae shape, Opa1 function, apoptosis and bioenergetics. This project will not only characterize the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structured, not stirred: experimental evolution in programmable antibiotic landscapes' (EvoSpa).

assistant: **Innovation**

Given the looming antibiotic resistance crisis, it is imperative to understand the fundamental determinants of resistance evolution dynamics. When antibiotics are administered to a patient, imperfect drug penetration leads to a highly inhomogeneous concentration profile. In contrast, evolution experiments to study resistance are commonly performed in homogeneous liquid environments. Recently, there has been a surge of theoretical studies suggesting that spatial drug concentration gradients drastically accelerate resistance evolution as resistant mutants evade resource competition by invading drug-enriched territory. However, the effect of spatial structure on evolutionary dynamics remains unclear due to a lack of experimental assays with well-defined, inhomogeneous landscapes.Here, I propose to develop a novel experimental assay where bacteria migrate and evolve on a landscape consisting of hundreds of independently definable environments. This assay will be implemented using custom liquid handling and imaging robots to systematically program antibiotic landscapes and measure evolution on a wide range of drug environments. By combining this novel assay with theoretical modeling, I will investigate evolution in monotonous and rugged drug landscapes. Motivated by theoretical predictions that multi-drug strategies aimed at preventing resistance evolution become compromised in inhomogeneous environments, I will further investigate the effect of spatial inhomogeneity using defined multi-drug landscapes. This project will provide a unique, quantitative and systematic experimental investigation on how spatial structure affects evolutionary dynamics. Beyond bacteria evolving antibiotic resistance, the same concepts apply for tumor resistance evolution. Overall, this project wil