RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Metal-organic frameworks as concerted proton-electron transfer mediators for electrocatalysis' under Horizon Europe.

assistant: **Concept**

As the consequences of the anthropogenic contamination become more evident and irreversible, there is an increasingly urgent need to switch towards more sustainable paradigms in the chemical industry. In this context, the utilization of renewable energy sources via electrocatalysis has emerged as a highly active field of research during the past decades, although further efforts are required to provide economically viable technologies with practical applications. eCat-MOF project aims at developing efficient electrocatalysts for chemical reactions based on reductive protonation. These processes are ubiquitous to a large number of industrially relevant transformations such as reduction of olefins, carbon dioxide or dinitrogen. An electrocatalytic approach will offer a sustainable alternative to harness renewably sourced electricity to power such transformations, avoiding current harmful processes that pose important obstacles towards a circular economy. The strategy of eCat-MOF project is based on accessing concerted proton-electron transfer (CPET) reactions due to their energetic benefits allowing operation at milder potentials and thus outcompeting the otherwise dominant hydrogen evolution reaction. To this end, eCat-MOF will target the design of novel CPET mediators based on an interdisciplinary approach: incorporation of molecular redox and acid/base mediators in the structure of metal-organic frameworks (MOFs) and the immobilization of the resulting materials on carbon-based electrodes. This strategy merges the fields of molecular inorganic/organometallic chemistry, reticular materials and heterogeneous electrocatalysis to overcome challenges associated to undesired bimolecular reactivity, low current density, limited Faradaic efficiency, difficult product separatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Organic Mixed Ion and Electron Conductors for High-Energy Batteries'.

assistant: **Innovation**

Energy storage is undeniably amongst the greatest societal challenges. Batteries will be key enablers but require major progress. Battery materials that promise a step-change in energy density compared with current Li-ion batteries rely on fundamentally different reactions to store charge, e.g. Si alloying or O2 reduction instead of intercalation. They have in common high volume changes on cycling and poor conductivity. For the active component of a battery electrode to function it must be simultaneously in contact with ionic and electronic pathways to electrolyte and current collector. State-of-the-art conducting additives and binders in the composite electrodes cannot ensure ideal contact for such materials and fail to exploit their full potential.In this project I directly target these fundamental challenges of high-energy batteries by replacing now used conducting additives and binders with flexible organic mixed ion and electron conductors that follow volume changes to ensure at any stage intimate contact with ions and electrons. This requires progress with the fundamental science of such conductors, for which to achieve we develop and combine synthetic, electroanalytic and spectroscopic methods, aided by theory. Mixed conducting polymer gels, designed for the particular storage material, shall be elaborated for two ultra-high capacity electrodes, the O2 cathode and the Si anode.The significant advantage, next to intimate contact, is that the packing density of active material can be maximized. This boosts energy stored by total electrode mass and volume by rigorously cutting the amount of non-active materials compared with current approaches. The expected overriding scientific impact includes improved understanding of mixed conductors concerning synthesis, structu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced Postdoctoral Training Programme', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Breakthroughs in Biomedical Sciences cannot be planned but for the most creative researchers to excel and for innovative fields to emerge, it is vital to create the most favorable scientific environment. One of the major challenges in the Biomedical Sciences is to have internationally competitive leaders in academia, industry or technology, who are outstanding in research but also extremely efficient managers. For this, we need to bring together professionals with expertise in Biomedical Sciences and Engeneering, as well as Communication and Management, to provide advanced high-level education that promotes science and technological development that truly translates to industrial and clinical application. However, most research institutions lag to provide adequate training at the postdoctoral level.This project attempts to fill this gap with the creation of a novel Advanced Postdoctoral Training Programme at the Instituto de Medicina Molecular - a biomedical research institute in Lisbon. We will create a new programme featuring incoming transnational mobility and reintegration of fellows that combines the extensive range of biomedical research at the IMM and the excellent technological expertise of our partner the Institute for Biotechnology and Bioengennering in Lisbon. We will offer fellows the opportunity to join an internationally competitive research group to develop an individual research project in a stimulating and truly multidisciplinary scientific environment. Fellows will take part of hands-on complementary skills training activities and individual coaching for the preparation and submission of grants. They will also have a unique opportunity to test the potential for technological development of their scientific ideas by performing secondments at IBB and of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'bio-inspired full-speCtrum blOck-copoLymer phOtonic strUctuRal pigments' (COLOUR) targeting Horizon Europe.

assistant: **Abstract**

Photonic pigments are one of the most exciting topics in optics as they are expected to lead to a pure and brilliant colouration free from chemical- or photo-bleaching, which is a central goal in the future developments of paints, cosmetics, displays, and advanced photonic devices. Till now most efforts have been focused on amorphous packings of colloidal crystals, but limitations of synthesizing large quantities of photonic pigments based on these arrays are only beginning to emerge. Novel materials and approaches are thus necessary and, in this context, COLOUR aims to develop bio-inspired photonic pigments via the combination of structural colouration and light absorption. The key approach is to exploit the 3D self-assembly of block copolymers in concentric lamellar structures to generate full-spectrum photonic crystals with high reflectivity and angular independence, coupling these with broad-band absorbers to ensure colour purity and vividness. Specifically, high-visibility structural colour able to address the limitations of current photonic pigments will be achieved by altering four variables, namely size, blackness, refractive index, and arrangement of the nano-elements. COLOUR will rely on my competencies in polymer processing and characterization and the expertise of the host supervisors Prof. Ullrich Steiner and Prof. Christoph Weder in the domain of soft matter physics, polymer self-assembly, supramolecular polymers and materials science (outgoing phase, Adolphe Merkle Institute, University of Fribourg - Switzerland), and Prof. Davide Comoretto in photonics (incoming phase, Department of Chemistry and Industrial Chemistry, University of Genova – Italy). COLOUR offers me the unique opportunity to acquire technical skills and experiences in several scientific f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts' (Lifebrain) under Horizon 2020.

assistant: **Objectives**

Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 6.000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive/mental health measures for extensively broader cohorts, exceeding 40.000 examinations in total. By linking these data, also to additional databases and biobanks, including birth registries, national and regional archives, and by enriching them with new online data collection and novel measures, we will address risk and protective factors of brain, cognitive and mental health throughout the lifespan. We will identify the pathways through which risk and protective factors work and their moderators. Through exploitation of, and synergies with, existing European infrastructures and initiatives, this approach of integrating, harmonising and enriching brain imaging datasets will make major conceptual, methodological and analytical contributions towards large integrative cohorts and their efficient exploitation. We will thus provide novel information on brain, cognitive and mental health maintenance, onset and course of brain, cognitive and mental disorders, and lay a foundation for earlier diagnosis of brain disorders, aberrant development and decline of brain, cognitive and mental health, as well as future preventive and therapeutic strategies. Working with stakeholders and health authorities, the project will provide the evidence base for policy strategies for prevention and intervention, improving clinical practice
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Control of the Homeostasis of Actin through Time: actin homeostasis during embryonic development by means of single-molecule imaging and simulation in C. elegans' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In embryonic cells, actomyosin forms a cortical reticulated gel that turns over rapidly, is weakly organized, and is composed of a variety of structures, with distinct architectures and dynamics, which are nucleated and elongated by different factors, and bind to specific sets of actin-binding proteins that modulate their dynamics. Understanding how actin is distributed between these structures is critical to understand the biology and mechanics of the actin cytoskeleton and therefore its role in processes ranging from morphogenesis and cell division to endocytosis and polarization.In the proposed work, taking advantage of single-molecule techniques I developed during my previous post-doc, I will use the early C. elegans embryo as a model system to tease out the general rules and the critical regulatory elements that control actin homeostasis. I will follow three major directions: (1) analysis of actin dynamics in a steady-state system, the 1-cell stage embryo during maintenance phase, (2) analysis of the mechanisms underlying actin homeostasis in face of changes in the concentration landscape and biochemical properties of the players and (3) analysis of the modulation of actin dynamics and homeostasis during early embryonic development and between different cell types.I propose here a research program to expand our knowledge of how the structure of the actin meshwork is regulated and controls morphogenesis in embryonic cells, and in particular the mechanical properties of the cell. Importantly this program explores how modulations of the concentrations of actin-interacting proteins impinge on the dynamics of the actin cytoskeleton as a whole, and should improve our understanding of the general mechanisms that underlie the regulation of the actin cytoskeleton machinery,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Next Generation MS SPIDoc’s' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

SPIDoc’s DN stems from the need to prepare for emerging viruses enabling a fast response, as became evident lately. Basically, better knowledge of the dynamic nature of viral structures is required and fundamental to combat with appropriate treatments. In this perspective, several technologies were developed for structural biology, including a cutting-edge approach combining mass spectrometry (MS) and X-rays for single particle imaging (SPI) in MS SPIDOC. Despite these advances, a major bottleneck that the scientific community will face in coming years will be the lack of expertise with a broad knowledge from theory, instrument development and application relevant to structural biology with MS.SPIDoc’s therefore aims to train the next generation of scientists with such expertise by a dedicated intersectoral training programme. SPIDoc’s projects are highly interlinked and the proposed training programme aims to provide the doctoral candidates with the basic and advanced knowledge to build a common interdisciplinary language, to work in teams and to acquire deep knowledge by a combination of lectures and practical sessions. An important aspect will be given to data management and the establishment of currently lacking standards for native MS metadata.The research training is complemented by transferrable skills courses, setting the basis for progressing through the doctoral studies as well as for future career progression. Within these modules, training on equal opportunities and unconscious bias are included, shaping the future generation towards creating fair workplaces. Special attention will be paid to green-practice measures from the everyday practice in laboratories and offices up to the institutional level. By including developments from computational theory to ins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'BIOIMAGE-Neuromuscular Diseases' (BIOIMAGE-NMD).

assistant: **Concept**

BIOIMAGE-NMD will develop and apply imaging technology to monitor response to novel therapies in neuromuscular diseases (NMD) and will use Duchenne muscular dystrophy (DMD) as an exemplar disease. DMD is well characterised genetically and clinically but to date a disease modifying treatment is not available. One of the most promising developments for future treatment of NMD is RNA modulation through antisense oligonucleotides (AON). In DMD, AON are used for exon skipping and this is a genuine example of personalised medicine, where patients are treated according to their specific gene mutation.Quantitative Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) are used to assess structural and metabolic muscle pathology in NMD but their effectiveness in monitoring therapy is yet to be shown.  The project will apply a simultaneous MRI/MRSI protocol in multi-centre clinical trials of AON therapy in DMD with the aim of establishing a clinical proof of principle that these imaging measures are effective biomarkers of therapeutic response. To enhance the imaging protocol, novel Diffusion Tensor MRI (DTI) methods will be developed and optimised to assess muscle microstructure and applied in these trials. The project will also develop methods for radiolabelling of AON and demonstrate the use of pre-clinical Positron Emission Tomography (PET)/MRI to assess the tissue targeting, bio-distribution and pharmacokinetics of AON in vivo.BIOIMAGE-NMD will deliver PET/MRI and MRI/MRSI technologies for both drug development and clinical evaluation roles which will significantly contribute to bringing personalized therapeutic interventions in rare and common diseases to the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Environmentally Acceptable Pretreatment System for Painting Multi Metals' (ENABLE).

assistant: **Concept**

With increasing demands from customers and public authorities on using environmentally acceptable processes there is a great need for SMEs within the metal surface painting industry to change pre treatment process. Today’s pre treatment system, zinc phosphating, is a chemical process with high consumption of water and energy and with use of potentially toxic chemicals like nickel and zinc. The need to substitute zinc phosphating is also related to pretreatment of light weight material e.g. aluminum and magnesium. These substrates cause sludge formation and quality problems. New environmentally acceptable pre treatment processes based on non dangerous chemicals, free from heavy metals,  causing no sludge formation, and requiring less process control have been developed during the last 10 years. The project addresses the problem to replace the “standard” pre-treatment process for out-door use, zinc phosphating with a new process. This is the only way to meet the increasing demands from customers and authorities. The magnitude of the problem can be understood by the fact that the process in use has 40 years of experience and the new processes have a completely different way of protecting the product. The SMEP will considerably improve their competitive position by being in the lead with the new silane/zirconium based processes. That is if the “process for change” will be successful regarding selection, adaption and running the process and if the dissemination will succeed. The strategic objective of the project is hand-on- knowledge to the SMEs packaged in a “Tool box for successful implementation of new pretreatment systems”. The toolbox will contain procedures for how to evaluate, adapt and implement the new pretreatment systems and how to control the new pretreatment pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterization of the transporter responsible for the transport of free oligosaccharides from the endoplasmic reticulum into the cytosol' to be submitted under Fourth Framework.

assistant: **Abstract**

The biosynthesis of glycoproteins bearing N-linked oligosaccharides is accompanied by the release of free polymannose oligosaccharides into the lumen of the endoplasmic reticulum (ER). Recently I have shown that these oligosaccharides are transported out of this compartment into the cytosol. The aim of the project described herein is to characterize this ER-to-cytosol transport process for free oligosaccharides at the molecular level. Using permeabilised cells, microsomes, and inverted red blood cell/microsome chimeras I will obtain the first data concerning the molecular nature of this transport process including information relating to its specificity, saturability and kinetic properties. These important data will provide the basis for the purification strategy that will be undertaken in order to more fully characterize the transporter molecule. Understanding the mechanism of the ER-to-cytosol transport of free polymannose oligosaccharides will ultimately help identify the physiological purpose of this recently described process.