RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SECRETED FACTORS IN CARDIAC REMODELING PROVOKE TUMORIGENESIS AND END ORGAN DAMAGE IN HEART FAILURE' (SECRETE-HF) targeting Horizon 2020.

assistant: **Abstract**

The objective of SECRETE-HF is to demonstrate the effects of secreted factors from failing hearts to explain the etiology of multimorbidity in heart failure (HF). The project focuses on two co-morbid patterns: 1) the emerging susceptibility of HF patients for incident cancer, 2) the more established co-morbid conditions of renal, liver and pulmonary disease in HF. The rationale is: • HF treatment has improved, yet morbidity and mortality remain high, which can be attributed to co-morbid conditions rather than pump failure alone. • HF treatment  is heart-oriented, neglecting the systemic effects that come with HF, and the associated morbidity and mortality. • Using innovative experimental approaches such as organ transplant models, target finding, and deep phenotyping of clinical databases I will dissect HF-derived effects on tumor growth and organ damage. OBJECTIVES 1. To establish the effects of HF, due to different etiologies, using the state-of-the-art heart transplantation murine model with (spontaneous) formation of colon and renal tumors, and phenotype tumor growth, as well as the main HF-affected organs: kidney, liver and lungs. 2. Identification of the cardiac secretome using unbiased approaches. 3. Integrate the results and identify overlapping and diverse factors from different HF forms, and their consequences for tumor growth and kidney/liver/lung remodeling. 4. Validate discoveries in human cohorts with data on incident HF, cancer and organ function. 5. Create clinical algorithms to detect, monitor and act on extra-cardiac disease. WORKPACKAGES WP 1: Create HF, murine heart transplantation models; phenotype tumor growth and organ involvement. WP 2: Explore the proteomic, metabolomic and extracellular vesicle profiles from HF subforms. WP 3: Validate secreted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ReadyToSail', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The main objective of the idea behind ReadyToSail is the development and commercialization of a wireless real-time positioning, global communication and monitoring platform, mainly focused on marine environments. It includes some additional features like autopiloting and emergency calls. ReadyToSail will rely on the Galileo constellation and its most relevant service:  Search and Rescue. The ReadyToSail platform will be a device based on a modular architecture offering new user-oriented services in constant evolution, such as remote monitoring and alert management. Moreover, the proposed solution will be designed to be easily integrated with current SAT-AIS modules.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'TRANSITION -  Tool-Part-Interaction simulation process linked to laminate quality'.

assistant: **Objectives**

Highly integrated, complex composite structures require a thorough evaluation of processing tools and parameters in order to achieve a competitive time-to-market as well as a cost efficient solution.  The link between processing conditions and final laminate quality as to porosity and geometric deviations can be captured by processing simulation tools. Goal of this project is to adapt and implement two existing model approaches into an ABAQUS framework to be able to validate and adapt the tooling concept early in the design process. One of the models will be implemented as a subroutine in ABAQUS to capture the prepreg consolidation depending on the prevailing processing conditions, while the second model is subsequently capable of predicting the porosity within the part depending on the temperature and pressure history. The predicted part quality will be compared with physical experiments on parts with increasing complexity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Biological invasions: patterns and processes. An integrative approach with the Bullfrog Rana catesbeiana in Canada and Europe'.

assistant: **Concept**

The impact of biological invasions upon native ecosystems and human economies is now widely appreciated. The phenomenon is a major scientific challenge, the frequency of non-indigenous species introduction is inevitably increasing, and the societal concern on this topic is remarkably high. Our proposal aims to develop an integrative approach to understand the processes of invasion. Our model is the Bullfrog, which pose a particular risk to biodiversity in aquatic ecosystems of special biodiversity interest. It is now introduced in several countries in Europe and appears to expand its range.Our proposal is to assess the mechanisms of biological and human influences playing a role in the persistence of introduced Bullfrog populations. We will use an integrate framework of data from diverse sources to propose effective biological control strategies in Europe and abroad. This will allow a rapid and efficient response when new introductions inevitably occur. Our proposal covers: A-Invasive biogeography: We will analyse Bullfrog genetic variation in Canada and Europe by the use of mitochondrial markers which allow understanding the origin and patterns of introduction events. B-Population functioning: populations are often connected in larger meta-population and the matrix (structure, distance between patches) affects colonisation and extinction processes. With modern models of genetic structuring (landscape genetics), we will estimate genetic spatial structure (with nuclear markers) and connect it with landscape feature in both native (US) and introduced populations.C-We will compare demographic traits and build population dynamics models to assess invasiveness. Data on frog migration, human role in active/passive displacement will be collected. Our objective is to use a hier
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Melt Electrowriting of Multi-layered Scaffolds for osteochondral defect repair (MEMS)' (MEMS), addressing dissemination and exploitation.

assistant: **Impact**

An osteochondral (OC) defect is a focal area of joint damage that involves both the articular cartilage and the underlying subchondral bone. Such joint damage is strongly associated with the development of premature osteoarthritis, motivating the development of novel strategies to regenerate OC defects. 3D printing is enabling the manufacturing of geometrically complex biomaterial implants with user defined compositions and architectures, which can potentially be used as single stage, off-the-shelf scaffolds for treating complex injuries. Despite significant progress in this field, 3D printed scaffolds capable of regenerating OC defects remain elusive. This can potentially be linked to the spatial resolution possible using traditional additive manufacturing techniques. The melt electrowriting (MEW) technique has recently emerged as a novel additive manufacturing platform capable of producing polymeric scaffolds with fiber diameters in the submicron range in a highly controllable manner. We have recently developed MEW scaffolds that support superior bone regeneration compared to scaffolds produced using traditional additive manufacturing techniques. Furthermore, we have generated preliminary data demonstrating that multi-layered scaffolds generated by MEW are capable of enhancing the repair of critically sized OC defects in a pre-clinical large animal model. The MEMS project aims to further enhance the regenerative capacity of these MEW OC scaffolds by (i) optimising their architecture, and (ii) functionalizing their surface with extracellular matrix (ECM) components supportive of tissue-specific regeneration. The output of MEMS will be an off-the-shelf implant capable of directing endogenous OC defect regeneration without the need for delivering exogenous cells to the d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Origin and evolution of land plant reproductive system' (EVREP) targeting Horizon 2020.

assistant: **Abstract**

Land plants constitute a significant part of the world’s biomass and the human diet. The transition of plants to a land-based habitat led to profound developmental innovations. A major change was the formation of a sexual-based reproductive system. In basal land-plant linages, the haploid-gametophytic phase dominates the life cycle. In later linages the diploid-sporophytic phase took a more prominent role. This switch involved the elaboration of an embryo-based reproductive system. However, there is a significant gap in our understanding of the evolutionary, genetic and developmental mechanisms that enabled the formation of a sexual reproductive system. We hypothesize that embryo evolution entailed two key consecutive events: 1. Cell proliferation and growth following fertilization and prior to meiosis, which generates the sporophyte. 2. Specification of a subset of cells as sporogenous cells, which will generate the spores. Based on published work and recent data from the host lab, we propose that the first step involves class I KNOTTED1-like homeobox (KNOX1), and the second, class III Homeodomain-Leucine Zipper (C3HDZ). In the proposed research, we aim to use the basal land plants to 1. characterize the role of KNOX1 genes in sporophyte formation and 2. Identify regulators of sporogenous formation by identifying C3HDZ targets and determine their role in sporogenous specification. The proposed research is expected to elucidate the molecular network underlying reproductive development of land plants and its evolution. This may unravel basic principles of developmental innovations that enable the evolution of land plants and the conquest of novel habitat. This postdoctoral fellowship will provide me with an opportunity to be trained in the field of evolutionary-developme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Unified Sustainability Index Framework for Small and Medium Enterprises' (UNIFORM) targeting Horizon 2020.

assistant: **Abstract**

The goal of this Fellowship, entitled “A Unified Sustainability Index Framework for Small and Medium Enterprises” (UNIFORM) is to train a talented researcher through a multidisciplinary research project bringing together aspects from economic, social and environmental sciences while using advanced statistical techniques. The Fellow – Dr. Malesios – will be trained on enhancing sustainability of small and medium sized enterprises’ (SMEs) supply chains of the EU countries to become an expert in the field, receiving access to a unique training experience at the host – Aston Business School (ABS) and co-hosts. [UNIFORM] will identify the associations to implementing environmental agendas within SMEs’ core business strategies and the more general concept of sustainable practice and sustainable development. According to our knowledge, up to now there has not been presented a unified methodology in order to measure and incorporate sustainability in SMEs, especially targeted towards sustainable supply chain practices. We will provide significant assistance in synthesizing evidence to assist develop sustainable managerial policies in this sector and to make environmental management a core activity that SMEs will need to engage in, along with the already existing operational factors. Incorporating sustainable development practices into SMEs’ supply chains is regarded as an overarching long-term goal. At the same time, the transfer of knowledge from the Fellow to the host members of ABS related to statistical methodologies and their implementation to various fields of research, will be another goal of the project. The results and deliverables produced by the project will contribute to the enhancement of EU scientific excellence in various ways. For instance, the [UNIFORM] online t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of nuclear gene flow in the evolutionary history of Pleistocene mammals' (GENEFLOW).

assistant: **Concept**

How important are environmental barriers between species and populations now and in the future? Currently, environmental barriers to movement across habitats that have persisted since the last ice age are breaking down, resulting in gene flow among previously isolated populations and even hybridization between species. What are the consequences of this gene flow? Local genetic adaptations to the specific conditions of a habitat are though to be threatened when gene flow occurs, but we know little about the long-term evolutionary effects such events have on species. Recent ancient DNA work on polar and brown bears even suggests that gene flow may be beneficial, rather than detrimental for the adaptation and survival of species during times of rapid climate change.This project aims to investigate the extent of gene flow among and its effect upon the survival, adaptation and evolutionary history of temporarily isolated populations of animal species during periods of rapid climate change. This goal will be achieved by looking back into the late Pleistocene, when our world experienced repeated and rapid periods of massive climatic change to which species had to adapt.The project will target the evolutionary history of four species (mammoth, spotted hyena, cave bear, and grey wolf) by sequencing large parts of the nuclear genome of each species across both time and space. In each species conflicting evolutionary histories are provided by morphological and mitochondrial DNA analyses, suggesting that (so far undetected) gene flow of nuclear DNA must have occurred. Undetected gene flow may explain aspects of their evolutionary history, and also the way these species adapted to the rapidly changing environmental conditions of the late Pleistocene.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Women on Biotechnology Scientific and feminist approaches' in the context of a Sixth Framework call.

assistant: **Objectives**

The project Wonbit is aimed at organising a Conference on women in biotechnology, in order to produce specific recommendations for improving the situation of women working in the field, and for gaining more knowledge of biotechnology impact on life and environment that could facilitate women to suggest new rules and laws on these topics.A further aim is to promote a confrontation between women scientist and feminists in order to facilitate a dialogue between different cultures (humanistic and scientific), which often are on opposite positions. According to these goals a survey on the women presence in biotechnology (both in industry and in Academy) will be performed in order to provide figures on their positions.On the other side, the different feminist attitudes to biotech will be identified, in order to select appropriate speakers. Finally, the conference will be structured around four different areas, and in each of them women experts will be invited as lecturers. Space will be devoted also to short presentations by selected women according to the abstracts presented.A Scientific Committee (covering the biological, sociological and economical expertise) will be appointed from the beginning, to co-operate with the organizers on the theoretical aspects of the conference. After the conference, recommendations will be provided both for promoting women in biotech and to facilitate the dialogue with the feminist movement and society at large.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Industrialization and commercialization of a competitive, sustainable and consumer oriented alternative animal protein source' (Meat4All).

assistant: **Innovation**

Meat4All's goal is to scale up cultured meat production technology, work on market acceptance and perform safety assessment tests to allow the industrialization and commercialization of poultry cultured meat. This project will allow to supply the ever-increasing global demand for animal protein while addressing the main drawbacks of factory farming industry: Health issues, environmental sustainability and animal welfare. By scaling up this technology Meat4All will create a new area of development that makes possible for the European industry to harness this market high potential, fostering competitiveness and creating growth throughout the EU. BF, with the collaboration of OT (peptone-based supplements) and NOB (SIGMA group; meat processors) proposes this project in order to take Cultured Meat production a step closer to the market. This project will allow BF to become a worldwide leader in Cultured Meat with the necessary production capacity to supply the meat processing industry, starting with NOB’s final innovative products. The project objectives are: • Scale up production process from 135 Kg scale to 10 Tons scale per year by 2021• Maintain large nutritional value for large scale produced quantities • 100% animal free origin culture media • Maintain Health claims up to the final processed products• >80% bioreactor yields to keep prices within the acceptable level• 100% traceable Non-GMO animal cells• Meat4All will produce cultured meat in a raw format to be processed into consumer products as sausages or cold cuts. The average target selling price will be 6 €/kg in 2023• Create markets leaders• Perform consumer product trials (tasting) aimed at ascertaining and predicting market and consumer demand.


**Keywords:** cultured meat, novel food, processed meat products
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The education of the youth as an initial state on the labour market - calendar time effects and cousality directions on the observed following transitions'.

assistant: **Concept**

Research objectives and content The research is focused on the analysis of the relations existing between the durations in the schooling system and duration spent in other states of the labour market like, for instance, unemployment, work, stage. These relations will be studied for a particular category of people: the youth This will be done via duration and transition models. In this kind of models, applied mostly in the analysis of event histories, the dependent variable is the duration spent by an individual in a given spell and this duration is explained by various individual and sociological features. A key concept in this framework is represented by the hazard function whose economic meaning is the probability of leaving a given state. Among the explanatory variables we will consider calendar time that seems to be able to affect in a strong manner young people behaviour on the labor market We will then ask if the level of education attained affects in a sistematic way either the probability to find a job, or the probability to keep a job or moreover the probability to exit towards another state. Using this framework we wish to study causality (cf. Granger causality) between for instance durations in unemployment and durations in the schooling system. In the empirical analysis we will make use of the data collected by INSEE in the Enqujte Emploi 1990-1992 and in the Module Jeunes 1992. Training content (objective, benefit and expected impact) The evidence found in most of the literature exploring youth labour market problems indicates that the individuals' level of education is very important; in particular the more educated is people, the less their unemployment spells will last. According to this we may ask if the length of schooling cause the length of the durat