RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Heart and respiration in-car embedded nonintrusive sensors' to be submitted under Seventh Framework.

assistant: **Abstract**

Road accidents are a major safety problem in developed countries, and fatigue is one of the critical factors. In-vehicle fatigue detectors can reduce this problem, saving 4,000 lives and preventing tens of thousand injuries every year in the EU, which in economical terms would imply annual savings of €7 Billion. For this reason, automotive OEM and TIER 1 are striving to achieve good solutions for automatic fatigue detection, but current approaches have strong limitations, because they lack the direct information about drivers’ physiological variables, which are critical for a successful evaluation of their state.This project gathers a consortium of SMEs that produce vehicle components (seat cover textiles and safety belts), smart materials, and sensors for biomonitoring, who will create a product to address that need. They will join their experience to create a nonintrusive sensor system of heart and respiration with smart materials, embedded in the seat cover and the safety belt of a car. This device will detect the effect of heart and respiration activity, filter and cancel the noise and artefacts expected in a moving vehicle, and calculate the relevant parameters, which will be delivered in a readable format to integrate it in a fatigue detector. The achievement of this objective will require to perform a research to develop new sensing materials, and create a signal processing unit to filter and process the data.This project will provide the SMEs with new, high technology products to sell in their sectors, and will help them to enter or improve their position in the automotive market, with a new device that will enable the creation of reliable fatigue detectors.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Epigenetic regulation of cardiac regeneration after injury.'.

assistant: **Concept**

Cardiovascular disease is a leading cause of morbidity and mortality worldwide, and there is a constant and urgent need for novel, more effective therapies to treat it. Chronic tissue hypoxia, nutrient deprivation and myocardial cell death are some of the factors contributing to ischemic heart disease (IHD), the most common cause of death from all cardiovascular diseases. Current therapeutic approaches are limited in their capacity to enhance cardiac regeneration after injury. Toward novel selective therapies, it is important to gain a detailed understanding of pathways orchestrating cardiomyocyte proliferation during development and after injury.This proposal aims to map the epigenetic landscape of cardiomyocytes at key stages of postnatal cardiomyocyte maturation, using the assay for transposase accessible chromatin with high-throughput sequencing (ATAC-Seq). The application of this novel technique to cardiomyocyte biology will allow for the identification of epigenetic mechanisms that drive cell cycle withdrawal during cardiomyocyte maturation. My pilot experiments indicate that the SWI/SNF chromatin remodeling factor Arid1a may prevent efficient cardiac regeneration after injury. The role of Arid1a during cardiomyocyte maturation will be characterized. Furthermore, I will examine if suppression of Arid1a in adult mouse heart can improve cardiac function and enhance regeneration after injury.Mapping the epigenetic landscape of developing and mature cardiomyocytes represents an important step toward understanding the obstacles to efficient myocardial regeneration. Manipulation of Arid1a in diseased hearts may provide novel therapeutic approaches to enhance cardiac regeneration post ischemic injury.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Supporting innovation of SMEs in the mobile services and application supply business' in the context of a Sixth Framework call.

assistant: **Objectives**

The focus in this project is on SMEs that are developers/suppliers of innovative solutions to providers of mobile services and applications (MSA). They are well known for generating the creative user oriented MSA that business and society needs/wants. In common with many SMEs, they face significant challenges as they develop and mature.This project will stimulate the development and use of mechanisms to support their innovation activities including involvement in FP6 activities. It will conduct studies of the demands of such SMEs for innovation support, the supply of the information and other resources that they will need and the channels that connect the supply and SMEs. The full dissemination of the ideas behind, and the findings, of the studies is achieved. FP6 provides an environment in which a holistic approach to SME innovation support services can be studied and developed. FP6-IST will invest substantially in the RTD needed for success in the MSA market.Diffusion of the fruits of these investments to SMEs is required. We see this project boosting such diffusion in a number of ways, particularly by encouraging the MSA-SMEs and the firms that support their innovations to benefit from FP6 projects. Few would doubt the potential for MSA-SMEs to enhance their performance by accessing external expertise, services and sources of information but their precise priority needs have not been ascertained and are unlikely to be determined without initiative. This project aims to increase clarity about such requirements.Currently the MSA innovation information and knowledge supply market is underdeveloped and fragmented as is knowledge about the usage and channels. Finding channels and matching them to individual needs are a challenge in too many instances. This project will co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European Union Basin-scale Analysis, Synthesis and Integration (EURO-BASIN)' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

EURO-BASIN is designed to advance our understanding on the variability, potential impacts, and feedbacks of global change and anthropogenic forcing on the structure, function and dynamics of the North Atlantic and associated shelf sea ecosystems as well as the key species influencing carbon sequestering and ecosystem functioning. The ultimate goal of the program is to further our capacity to manage these systems in a sustainable manner following the ecosystem approach. Given the scope and the international significance, EURO-BASIN is part of a multidisciplinary international effort linked with similar activities in the US and Canada. EURO-BASIN focuses on a number of key groups characterizing food web types, e.g. diatoms versus microbial loop players; key species copepods of the genus Calanus; pelagic fish, herring (Clupea harengus), mackerel (Scomber scombrus), blue whiting (Micromesistius poutassou) which represent some of the largest fish stocks on the planet; piscivorous pelagic bluefin tuna (Thunnus thynnus) and albacore (Thunnus alalunga) all of which serve to structure the ecosystem and thereby influence the flux of carbon from the euphotic zone via the biological carbon pump. In order to establish relationships between these key players, the project identifies and accesses relevant international databases and develops methods to integrate long term observations. These data will be used to perform retrospective analyses on ecosystem and key species/group dynamics, which are augmented by new data from laboratory experiments, mesocosm studies and field programs.  These activities serve to advance modelling and predictive capacities based on an ensemble approach where modelling approaches such as size spectrum; mass balance; coupled NPZD; fisheries; and “end to end”
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reality Sensing, Mining and Augmentation\nfor Mobile Citizen–eGovernment Dialogue' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Bringing policy makers closer to real life of citizens is the objective of Live+Gov. We will develop a mobile government solution that allows citizens to accurately express their needs to government by using a variety of mobile sensing technologies available in their smartphones (GPS; image/audio recording; compass, orientation sensors, etc.) next to established means of mobile eParticipation such as textual input and output. Sensing and mining data from the real world, such as geo-located images of street damages or GPS track recordings during traffic disruption, government achieves accurate analyses of citizens' needs and opinions and can take advantage of a collective citizen intelligence. Live+Gov develops novel policy models and links data contributions by citizens to existing administration processes. The Live+Gov key feature is that it fully exploits the capabilities of widely proliferated smartphones for mobile eParticipation, rendering an augmented reality of governmental actions and plans, such that citizens obtain fast and comprehensive feedback on issues they encounter. Anonymization, data randomization and access control will safeguard against misuse and ensure privacy for all involved. Live+Gov will be delivered in a Software-as-a-Service model packaging its fully developed software components such that take-up is possible at dramatically lower cost of operations. Success will be measured through three live field trials (mobility, urban maintenance, urban planning) conducted by partners already operating end-user platforms  in these domains and reusing existing governmental data. The methodology, solution, and experiences made in field trials will be published through a combination of open source, public reports and open workshops. Field trials and exploit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transcriptional adaptation during vertebrate development at the single-cell level', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The development of a multicellular organism requires the precise control of gene expression in space and time so that cells adopt their correct identity.  However, genetic mutations can alter this complex process.  Recently, transcriptional adaptation (TA) has been uncovered as one of the mechanisms underlying genetic compensation in zebrafish, mouse cells in culture, and Caenorhabditis elegans.  TA refers to the phenomenon by which mutated genes (often with mRNA-destabilizing mutations) trigger the transcriptional modulation of related genes, called adapting genes.  However, little is known about the spatial and temporal characteristics of adapting gene regulation and particularly during the zygotic genome activation.  This project aims to decipher when and where TA occurs during early zebrafish development.  Using genome engineering followed by live imaging, high-resolution microscopy and quantitative analysis, I will test the hypothesis that TA is regulated in a temporal manner during zygotic genome activation and that there is a specific mode of transcription during the modulation of the adapting genes (i.e., linear/discontinuous).  Furthermore, I will investigate the subcellular localization of mutant mRNA degradation as well as the heterogeneity of the TA response between embryonic cells.  Finally, I will implement the live imaging of translation in zebrafish embryo to decipher whether the dynamics of translation is involved during the TA/genetic compensation process.Until now, TA has been mostly investigated on pooled populations of cells.  Therefore, we lack the understanding of this phenomenon at the single cell level.  This project aims to fill this gap and obtain a better understanding of the spatio-temporal characteristics of genetic compensation which aid i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Diamind- Drying Innovation and Milling Innovation Drive' (DIAMIND) under Fifth Framework.

assistant: **Objectives**

The proposed project aims to demonstrate the technical and financial fiability of a new, energy efficient process for drying, classifying and milling of blast furnace cement. The proposal aims to prove that the proposed technology, based on the VSK-separator - roller press combination, will boost the wider use of blast furnace cement (causing a reduction of the use of natural resources, energy savings) and has a wide application potential in the cement industry and other industrial sectors such as mineral processing, ore milling, coal processing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'TREESURE- Decision support Tool for Risk Evaluation, management and awarenEsS of tree FailURE Disasters' (TREESURE).

assistant: **Concept**

The role of urban forests in local ecosystems has been widely acknowledged with their benefits ranging from leisure to climate change mitigation. However, with the growing intensity of windstorms affecting Europe and the increasing risk of tree fall, afforestation might become a part of the problem it attempts to solve: damage caused by meteorological events. Parallel to this, tree cutting might elicit a mixed response from the public, further exacerbated by misinformation. Hence, the aim of the TREESURE project is to provide decision support system for tree health monitoring, co-created and co-designed by the array of local stakeholders (risk managers, practitioners, local authorities and associations) representing different pedoclimatic zones across Europe for improved coordination and more tailored responses at the local level increasing resilience to natural disasters. To tackle this challenge, the TREESURE project offers the decision-support system, which will combine the satellite data coming from ESA with the data collected by the IoT sensors. Nature based solutions as root-anchoring systems will be its key feature. Deployment of this system in 3 different geographies will be preceded by in-depth case study requirement analysis, involving social, environmental and technical aspects. Key stakeholders will be engaged from the very outset of the project, starting with tabletop games. Their ownership of the TREESURE solutions will be increased by them taking part in assessment of the dashboard and app prototype and co-creating the user guidelines and policy toolbox. Ultimately, the key stakeholders will take part in the scenario testing, highlighting the importance of early warning, damage control and misinformation. This is expected to increase their engagement on p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of inovative multi-target drugs for ALS'.

assistant: **Objectives**

Amyotrophic Lateral Sclerosis is a severe neurodegenerative disease characterized by the degeneration of the upper and lower motor neurons (MN), ultimately leading to patient death by respiratory failure. Despite being the most common adult-onset motor neuron disease, the drugs available till now are symptomatic and only extend patients life expectancy a few months without changing the onset of the disease. Recent studies revealed that NF-κB transcription factor is the major regulator of neuroinflammation in ALS. Therefore, inhibitors of NF-κB signalling pathway can be considered key tools for the development of novel therapies for ALS. Additionally, the use of iron chelators have also shown potential to increase ALS survival through the regulation of iron redox activity and by triggering MN cell survival mechanisms through the mild activation of HIF transcriptional factor. In this project we propose an innovative therapeutic solution for ALS based on the design and syntheses of multitarget small-molecules capable to modulate NF-κB activity through inhibition of IKKβ protein and prevent/minimize the iron induced oxidative damage and/or stabilize HIF. The project encompasses the rational design and synthesis of a library of small molecules that will be submitted to an initial cascade of biophysical and chemical assays to evaluate their binding affinity and iron chelation properties. Subsequently ALS cellular models will be used in order to validate target engagement inside cells, as well as, to identify the small-molecules that could protect MN from oxidative-stress and inflation driven apoptosis. At the end of the project it is expected to propose a novel lead compound that will be optimized and its performance evaluated in ALS animal models. This project combines the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structural determination and dynamics of the mitochondrial import protein (MIM) by cryo-EM and magic-angle-spinning (MAS) nuclear magnetic resonance (NMR)' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Mitochondria perform numerous key functions, from energy production to metabolic pathways, and are involved in ageing and cell death. All these functions rely on about 1000 different proteins, of which 99% are synthesized outside the organelle and have to be imported and inserted into the right compartment. These import and insertion are particularly demanding for the membrane proteins as they are inherently aggregation-prone. How α-helical membrane proteins (MPs) are inserted into the mitochondrial outer membrane (MOM) is currently poorly understood. In particular, the structure of the insertase responsible for inserting tens of these α-helical MPs into this membrane, called mitochondrial import protein (MIM) in yeast, is unknown. My MitoMemInsert project addresses this important knowledge gap, by determining the atomic-resolution structure of MIM, by using cryo-EM combined with magic-angle-spinning nuclear magnetic resonance spectroscopy to resolve MIM’s structure in a lipid-bilayer environment. This will open avenues to see how the MIM complex engages with polypeptides that shall be inserted into the membrane by MIM (so-called precursor proteins or ‘preproteins’). Such a “static” structure determination would already be a big leap for the field: it will be the first structure of a MOM insertase of α-helical MPs. As it is thought to have a novel architecture, this structure will provide new insights into MP insertion machinery in general. In addition, I will use NMR to study the dynamics of this machinery, which I believe, will add important mechanistic knowledge of how the MIM complex engages with MPs that are being inserted in the MOM. Overall, making use of my previous technical expertise, and adding new competences to my skill set, a combination of biophysical and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Surveillance network of Reoviruses, Bluetongue and African Horse Sickness, in the Mediterranean basin'.

assistant: **Concept**

Bluetongue virus (BTV) and African horse sickness virus (AHSV) are reoviruses transmitted by vectors species belonging to the Culicoides genus that affect respectively ruminants and Equidae. BT disease has occurred sporadically in the Mediterranean region in the past, involving relatively short lived epizootics. Since 1998, large BT outbreaks affected different countries around the Mediterranean. The virus has extended further north than ever. During summer 2006, BT outbreaks were recorded in Belgium, Germany, Netherlands and France. This episode highlighted the the potential of BT to further established in Europe and presents a major risk to the livestock industry. AHSV outbreaks have occurred in Southern Europe in the past, especially in Spain from 1987 t o 1991. It causes one of the most severe diseases in horses. It is closely related to BTV and is transmitted by the same Culicoides vectors, hence regions at risk of BTV can be regarded at risk of AHSV. Considerable advances and expertise already exist on these both Culicoides-borne diseases, the viral agents which cause them, the vector, their spread, etc, but in many cases it is not readily accessible or could be significantly enhanced by better communication between the research centres involved, and imp roved dissemination of data. The coordination action will gather and share information on BT and AHS, (i) promote regional studies on the risks of introduction of new strains and spread with inclusion of neighbouring areas (North Africa, Turkey) as an earl y warning, (ii) survey the expansion of C. imicola in new northern territories taking into account the potential novel vectors group in Europe and (iii) improve information technology for storage, communication and sharing of vector and sentinel surveillance and