RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Process management and design system for microsystem technologies'.

assistant: **Innovation**

Although the margin with regard to other parts of the world is getting smaller, European microsystem technology is still leading and is one of the future economic domains with great potential and impact on almost all areas of technological development. A major reason for this success is the large variety of different microsystem process technologies, as most of the target devices such as MEMS and MOEMS require an application specific fabrication process. To keep and to extend the margin of European microsystem technology the PROMENADE project adds to reproducibility, manageability and time to market issues related to the maintenance of microsystem processes.Today technology information derived from simulation, tests or measurements is usually kept informally and non-systematically on paper, in Excel sheets or merely in the heads of process engineers and is hence hardly accessible for use in future process development projects. The objectives of the PROMENADE project are to realise a computer-based environment supporting process engineers in creating, verifying, simulating, optimising and maintaining thin film Si processes with predictable characteristics as well as designers of micro devices by offering them a formal interface to constraints from the technological domain and facilitating design for manufacturing.Special attention will be paid to respect IPR protection issues of users / partners and company specific IPR protection. A major part of the effort will be related to the generation of the simulation environment, implementing the developed empirical and physical models generated by the detailed physical study. Single process step simulations and characterisations as well as simulations of complete process sequences will be available to derive rules forming the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development and clinical evaluation of a drinking system for patients suffering from temporary deglutition problems' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Drinking is a complicated action. The deglution of liquid is co-ordinated by the brains and involves closure of the lips, development of negative pressure in the mouth (suction) and movement os the tongue and larynx. Furthermore drinking is influenced by the condition of the hands(trembling), the amount of administered fluid (cup or spoon), gravity and as a consequence by the position of the person, as well as by temperature and viscosity of the fluid. Therefore drinking may cause problems to persons with disturbed brain and muscle functions such as stroke patients and elderly persons. Also patients who have to lay on their back (most hospitalised persons) often have drinking problems. The aim of this project is to assess a drinking system on improvement of daily activities and reduction of costs of care of patients mentioned above. The drinking system will be composed of a reservoir, a straw and a mouth-piece that contains a valve that prevents back flow of the fluid. With this system every suction results directly in fluid intake and prevents aspiration. The materials used must be non toxic, not influence the taste of a product, temperature isolating, and must be recyclable or biodegradable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metabonomic Analysis of the Sulfate-Reducing Bacteria Response to Oxidative Stress Conditions' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Sulfate-reducing bacteria (SRB) are anaerobic prokaryotes characterized by sulfate-reduction into hydrogen sulfide as the major component of their metabolic process. Recently the vision of sulfate-reduction as a strict anaerobic process has changed, since SRB have been isolated from environments where oxygen is present. These SRB possess an arsenal of protection systems against the toxic effect of oxygen such as detoxification systems and oxygen reducing enzymes. SRB are very intriguing for ecological point of view; moreover, their metabolic diversity has been used in industry for bioremediation processes. SRB are able to reduce oxidized highly toxic heavy metals, such as uranium or chromate, in less soluble and less toxic forms. Regarding the great interest that SRB represent for ecologist and industrial, we need to get more insights into adaptive mechanisms of SRB to oxidative stress conditions. A better understanding of these mechanisms would help in optimizing use of these bacteria in biotechnological applications. While most of the studies have been performed using cDNA microarrays and proteomics analysis, we propose to analyze SRB response to oxidative stress by metabonomic approach, using Desulfovibrio vulgaris Hildenborough as model organism. This new approach would lead to identify and quantify metabolites changes in response to cells exposure to oxidative conditions, generated either by oxygen or heavy metals. Metabolites identification and quantification will be performed by combining both NMR and LC-Mass spectrometry. Related with proteome modifications, it would first help understanding changes observed at the genomic level and provide novel insights into the effect of oxidative stress conditions on anaerobic metabolism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SPRITES Optimisation of Bio-inspired Gel Scaffolds for Hydrogen Production' in the context of a Seventh Framework call.

assistant: **Objectives**

Results arising from the ERC Starting Investigator Grant, Introducing SPRITES (202706, Aug’08-Jul‘12) reveal that encapsulating synthetic molecules based upon the hydrogenase enzyme in a bio-gel material cause dramatic changes in chemical behaviour as well as significant improvements in their stability when exposed to air. These systems therefore offer exciting prospects for use as a scaffold material for hydrogen production catalysts in fuel cell applications, addressing an urgent need in the next-generation energy production sector. In this proof of concept study we will perform technical testing and validation of a library of material formulations using SPRITES spectroscopy to determine the most technologically-promising material. The output will be threefold i) a gel material capable of hydrogen production ii) a library of bio-gel formulations for use as catalyst scaffolds iii) a SPRITES screening procedure for advanced materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Stomatin proteins and olfactory transduction' to be submitted under Seventh Framework.

assistant: **Abstract**

In vertebrate the initial steps of olfaction occur in olfactory sensory neurons (OSNs), located in the olfactory epithelium in the nasal cavity. OSNs are responsible for the detection of odorant molecules present in the environment and the generation of the neural signal that is transmitted to the brain. OSNs are bipolar neurons with a single dendrite that terminates with a knob, from which protrude several tiny cilia, where the transduction of the olfactory signal takes place.Data obtained from different approaches have shown that several stomatin-proteins (stomatin, STOML-2, STOML-3) are highly expressed by OSNs and are localized on the cilia of OSNs.Proteins of the stomatin family are membrane-associated proteins characterized by the presence of a structurally conserved core domain called stomatin-domain of about 120 residues. They can form oligomers and can modulate ion channel activity, although the precise mechanisms of this regulation are still unclear.Here we will clarify the physiological role of stomatin-proteins in the olfactory system by using different knock-out mouse line for stomatin-proteins genes. We will examine if the lack of stomatin-protein alters the development of the olfactory system and in particular the sensory transduction apparatus. We will evaluate the olfactory sensitivity by using electrophysiological recording of odorant-evoked response by OSNs in the absence of stomatin-proteins and we will test the odorant-driven behaviors in null mice. Moreover, we will analyze the electrophysiological properties of transduction ion channels in mutant mice to test a direct modulation by stomatin-proteins.We will not only contribute to increase the understanding of olfactory transduction at the molecular level, but we will also identify possible new mec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The Making of the Byzantine Ascetical Canon: Monastic Networks, Literacy and Religious Authority in Palestine and Sinai (7th-11th centuries)'.

assistant: **Concept**

This research project will investigate the role played by the multilingual Christian monastic communities of Early Islamic Palestine and Sinai (7th-11th centuries CE) in the formation of the Byzantine literary canon of ascetic works. Throughout the Medieval period, Byzantine monks and ascetics across the Mediterranean relied as their main source of authority on the writings of the ""early fathers"", i.e. a series of ascetic authors who were active between ca. the 4th-7th centuries CE. The increasing spiritual authority invested in ascetic books and texts (the ""classics"") during the Byzantine period stands in stark opposition to the living examples of charismatic holy men and women who dominated Late Antique Christian discourses on asceticism. Although this shift from a personal to a literary type of authority had far-reaching consequences for the history of Byzantine Christianity, key questions with regard to the complex processes behind it never received an adequate treatment in scholarship: Where and when did the change take place and what was its scope? How did a ""canon"" of ascetic literature emerge, who carried out the selection of authors and works, and how was it disseminated? Employing innovative research methods from the fields of social and intellectual history, philology, manuscript studies and Digital Humanities, MonasByz argues that the fundamental shift occurred in Palestine and Egypt (Sinai) during the early Islamic period and that the monasteries of Mar Saba and St Catherine's played a pivotal role in this development. Through a systematic survey of the Greek, Syriac, and Arabic ascetic manuscripts produced in these centers between the 7th and 11th centuries, the project will identify the actors and resources involved in the production of books and re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dissecting the molecular building principles of locally formed transcriptional hubs' (DisMoBoH).

assistant: **Innovation**

Numerous DNA variants have already been identified that modulate inter-individual molecular traits – most prominently gene expression. However, since finding mechanistic interpretations relating genotype to phenotype has proven challenging, the focus has shifted to higher-order regulatory features, i.e. chromatin accessibility, transcription factor (TF) binding and 3D chromatin interactions. This revealed at least two enhancer types: “lead” enhancers in which the presence of genetic variants modulates the activity of entire chromatin domains, and “dependent” ones in which variants induce subtle changes, affecting DNA accessibility, but not transcription. Although cell type-specific TFs are likely important, it remains unclear which sequence features are required to establish such enhancer hierarchies, and under which circumstances genetic variation results in altered enhancer-promoter contacts and differential gene expression.  Here, we propose to investigate the molecular mechanisms that link DNA variation to TF binding, chromatin topology, and gene expression response. We will leverage data on enhancer hierarchy and sequence-specific TF binding to identify the sequence signatures that define “lead” enhancers. The results will guide the design of a synthetic locus that serves as an in vivo platform to systematically vary the building blocks of local transcriptional units: i) DNA sequence – including variations in TF binding site affinity and syntax, ii) molecular interactions between TFs, and iii) chromatin conformation. To validate our findings, we will perform optical reconstruction of chromatin architecture for a select number of DNA variants.  By simultaneously perturbing co-dependent features, this proposal will provide novel mechanistic insights into the formatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Support Action for Standardisation in Additive Manufactruring' (SASAM).

assistant: **Concept**

SASAM's mission is to drive the growth of AM to efficient and sustainable industrial processes by integrating and coordinating Standardisation activities for Europe by creating and supporting a Standardisation organisation in the field of AM.The Additive Manufacturing (AM) concept is based on additive freeform fabrication technologies for the automated production of complex products. Additive Manufacturing is defined as the direct production of finished goods using additive processes from digital data. A key advantage is that AM eliminates the need for tooling, such as moulds and dies, that can make the introduction of new products prohibitively expensive, both in time and money. This enables the production of forms that have been long considered impossible by conventional series production—in fact, they can be created fast, flexibly, and with fewer machines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Evolution of plant volatiles manipulation by vectored pathogens' in the context of a Seventh Framework call.

assistant: **Objectives**

Many important plant diseases are vectored by insects, and the dependence of pathogens and insect herbivores on a common plant host creates the potential for antagonistic and mutualistic interactions that may have large implications for disease transmission. Pathogen-induced effects on plant traits affecting their suitability for herbivores or the cues presented to foraging insects are likely to be central to these interactions. Yet, the ecology and evolution of plant-pathogen-vector interactions is not well understood. A few recent studies have shown that virus-induced plant organic volatiles are attractive to aphid vectors, but broader implications for disease ecology and pathogen evolution have not been investigated. I propose here to explore the ecology of vector-borne viral and bacterial pathogens of the wild gourd Cucurbita pepo subsp. texana. Previous work in this system suggests that infection by an aphid-vectored virus, ZYMV, and a beetle-vectored bacterial pathogen, Erwinia trachephila, are dependent on the selective behaviour of their respective vectors. I will thus explore the effects of pathogen-induced changes in plant volatiles and insect behaviour, and their impact on pathogen transmission. I will examine variation within natural pathogen populations for these effects, to gain a better understanding of their adaptive nature and their consequences in pathogen epidemiology and evolution. I will also develop a second study system, involving the plant Arabidopsis thaliana and a whitefly-vectored virus (CaMV) to extend this valuable model to questions relating to plant-pathogen-vector interactions, which would greatly facilitate the elucidation of underlying mechanisms. The proposed work will be performed jointly at the department of entomology of the Pennsyl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A review of acceptable means by which towed gear discards may be reduced in ICES areas VII and VIII' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The main objective of this Concerted Actions was to find a framework within which discards could be reduced in the towed gear fisheries of any given fishing area. Specifically the work aimed to:- Review the fisheries being prosecuted in Areas V11h and j and VIIIa and b;- Rview the available information on seasonal catch profiles and discard rates;- Determine the main biological and commercial aspects of those fisheries;- Agree national priorities for change through industry liaison groups; and- Seek consensus on the discard reduction priorities from the fisheries in question through a liaison group of fishermen from all four countries involved.CONCLUSIONSAfter this phase of the discussion the group went on to consider the ways in which a research proposal could be framed that would be acceptable to all concerned. The group agreed a number of general points about such a which would cover three main areas over a three year period:- Development and demonstration of technical measures intended to increase selectivity and reduce discards in appropriate fisheries,- Economic and biological modelling of the consequences of introducing these measures to the fleet. This would examine the economic effects at boat and fleet level and consider medium and long term predictions,- Examining a range of other factors, which may affect the feasibility of introducing, improved selectivity. These might include market dynamics, the import of small fish and the potential to devise 'hybrid' packages - for example a combination of new technical measures and quota swap arrangements.Working up the proposal would require liaison groups to be set up which would bring together each country's fishing industries and researchers. These Groups would be responsible for reviewing the draft research propos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Connecting neural networks: Nervous-system-on-Chip Technology' (CONNECT) under Horizon 2020.

assistant: **Objectives**

Novel micro-engineered in vitro models have been developed to mimic key functions of human organs. These so-called organ-on-chips (OoC) recapitulate the structure and function of human organs, and are particularly important for scientific research that is underlying our knowledge base of diseases and for the pre-clinical development of novel therapeutics. However, the application of these models has its limitations as they do not mimic the complexity and functioning of complete organ systems. Connectivity between cells and the linkage between different components of organ systems is essential in studying complex conditions such as neurodegenerative diseases. These diseases form a major challenge for the scientific community and are associated with a heavy burden on society and the global healthcare systems. To effectively grasp the complexity of neurodegenerative disorders, the CONNECT consortium develops the next level in vitro model systems for the nervous system and puts it firmly on the map. The project acts at the convergence of a multitude of disciplines including nanofabrication, microfluidics, stem cell technology, tissue engineering and advanced imaging. The successful completion of this high risk-high gain project will enable for the first time to study a complete organ system and deliver a viable paradigm for future technology to study connectivity in the nervous system. The proposed work in this project offers a unique opportunity to culture individual nervous system components and connect them in a single “smart” microfluidic chip (CONNECT platform), forming an elementary three compartment model from the central nervous system (CNS) to the peripheral nervous system (PNS). As Proof-of-Principle, CONNECT will demonstrate the feasibility of this system model i