RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A discovery tool for accelerated adsorption-diffraction analysis of dynamic adsorbents in gas separation' (DYNADIFF).

assistant: **Concept**

Synchrotron instrumentation plays a key role in the discovery of novel high performance materials. However, their application is limited to beam time available at large synchrotron facilities. The transfer of synchrotron based methods to a wider market of laboratory instrumentation poses significant market potential for SMEs and promotes accelerated materials discovery in industry. Responsive porous materials such as metal-organic frameworks are already recognized as highly selective adsorbents suitable to revolutionize separation processes by replacing established cryogenic distillation equipment in terms of enhanced energy efficiency and lower CO2 footprint. To unlock the potential of responsive porous adsorbents, industrial research departments, research institutes and academic institutions require advanced tools for analyzing dynamic solids in situ in the presence of gas mixtures in parallel to measuring mixture adsorption isotherms and diffraction patterns. DYNADIFF focuses on the development of an advanced adsorption chamber for parallelized (in situ) adsorption-diffraction analytics suitable for laboratory diffractometer adaption. The successful project completion will enable the commercialization of an advanced in situ instrument at reduced cost for laboratory use to promote the accelerated discovery and analysis of novel porous materials for highly selective and energy efficient gas separation processes and improved energy storage.


**Keywords:** Gas separation,  Porous Materials,  Metal-Organic Frameworks,  Advanced Instrumentation,  Responsive Materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Knowledge Transfer for Widened EU Excellence in Advanced Green Technologies, Sustainability and Research Management'.

assistant: **Innovation**

Critical minerals and elements are highly significant for Europe's economy, particularly within strategic sectors. However, the demand for new, often essential materials conflicts with the decreasing activity in primary raw material mining. As a result, there is an impending need to fulfil these demands within European borders, reducing reliance on third countries. This was recently reflected in the European Raw Materials Act as a clear necessity from the EU, being a potential solution the use of green and non-invasive technologies to recover and refine CRMs. Besides this, it is known that the reserves and productions of mineral resources in Slovakia are mainly located in Kosice region (46% Slovak geological reserves), thereby, enhanced networking and positioning activities between TUKE and the top-class leading research institutions are needed in order to close the still apparent research and innovation gap within the EU. Furthermore, TUKE is a distinguished mining university and serves as the primary reference centre within Slovakia, which will be boosted and reinforced in three main strategy lines through several learning tools and materials. These will be focused on: 1) exploration, recovery and mining monitoring exploitation, 2) capacity to drive sustainability, circularity and social assessment 3) Strengthening TUKE’s research management & coordination capacities, and administrative skills. The WIDEX implementation will include the creation of a new cluster in Central Europe, an excellent Virtual Centre, as well as a Stakeholder platform around the green and non-invasive technologies ecosystem, and a WIDEX’s WHITEBOOK based on the lessons learned.


**Keywords:** Critical Raw Materials, Circular Economy, Sustainable Mining, Resource Efficiency
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'BRAIN-SPINE INTERFACES TO REVERSE  UPPER- AND LOWER-LIMB PARALYSIS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

A spinal cord injury (SCI) alters the communication between the brain and spinal cord. The consequences are dramatic impairments of upper-limb and lower-limb motor functions, which have a profound impact on the affected person, their family, and society. Currently, there are no approved therapies for SCI. The resulting costs of care amount to more than 2.5 M? over the lifetime of a person with SCI. Two ERCs combined with two ERC-PoCs enabled us to prototype two brain-spine interfaces (BSIs) that link the intended movements decoded from motor cortex activity to precise electrical stimulations of the spinal cord to promote these movements. These BSIs restored walking and arm/hand movements in nonhuman primate models of SCI, and as we report here, enabled one patient with chronic paralysis to walk again outdoors. These prototypes were partly based on repurposed devices that were not optimized for the intended applications, and thus presented shortcomings. Here, we propose to integrate two breakthrough technologies to develop two fully-implantable BSIs that will remedy these limitations. The first technology consists of the only existing fully-implantable neurosensor for wireless monitoring of cortical activity in humans based on high-density grids positioned over the dura mater. The second technology is the only implantable neurostimulation system dedicated to the recovery of movement after paralysis. This system combines an implantable pulse generator that enables highly reliable, real-time control of spinal cord stimulation, and a portfolio of electrode arrays that have been designed to leverage the mechanisms through which this stimulation restores movement. Two small scale clinical trials will demonstrate that these BSIs restore lower-limb and upper-limb movements in h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Revolutionary Accuracy in waVeguide- and photoacoustic-ENabled atmospheric sensors (RAVEN)'.

assistant: **Concept**

Anthropogenic greenhouse gas (GHG) emissions and deteriorating air quality are driving climate change and severely impacting human and ecosystem health, respectively. To combat these issues, new and more stringent green regulations are being implemented globally, which existing air monitoring systems are not well equipped to handle. Currently available commercial sensors are expensive, bulky, and frequently require shelter and power from the mains. Field performance also often falls lower than required due to high signal noise and drift. Consequently, there is a need for new air pollution and GHG monitoring systems that offer improved sensitivity, precision, and accuracy while also being inexpensive, compact, and energy efficient. RAVEN will develop the next generation of gas sensing systems, consisting of two miniaturised gas sensors implementing cutting-edge PIC technology, one in the VIS-SWIR range and one in the MIR range. These sensors will work in tandem across a broad wavelength range (600-3000 nm) to measure concentrations of multiple pollutants and GHGs, including CO2, CO, O3, CH4, N2O, CH3OH, NH3, NO2 in 1-25 ppb LOD range. The sensors will leverage cutting-edge science, including developing a high-power compact dual-supercontinuum source on a chip and on-chip data analysis using a quantum-inspired approach for improved LOD and selectivity of gases and to satisfy the performance, power consumption, size, and cost requirements of end users. RAVEN will offer an unparalleled, high-performance multi-sensing solution that can be packaged into a single near-universally applicable miniaturised system. The implementation of RAVEN technology will provide Europe with the necessary resources to ensure compliance with the EU Green Deal and enhance the photonic technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multiplex qPCR detection and chemical analysis towards multifunctional diagnosis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Kidney Disease in England costs more than breast, lung, colon and skin cancer combined. In particular, chronic kidney disease (CDK) affects 10% of the population worldwide. This is bound to increase as our population ages and, if CKD is not detected early enough, the patient may progress to kidney failure which requires therapies (dialysis or transplantation) that are extremely costly and weighs heavily on healthcare budgets. Even though several cheap traditional tests already exist based on a diagnosis of urinal or blood samples, there is no technology available to measure both key RNA biomarkers of kidney diseases and perform traditional chemical analysis. The development of fast multiplex quantitative PCR (qPCR) technologies offers a unique opportunity to propose a Point of Care Test (PoCT) able to perform new multifunctional cheap diagnostics.By hiring an Innovation Associate with an expertise in microbiology and chemistry, ELVESYS wants to develop the first multifunctional, fast and affordable PoCT device for kidney disease diagnostics. This system will enable any practitioner to propose a diagnosis based on the simultaneous analysis of urinal and blood samples in a single test during the time of a visit to the doctor’s office. The Innovation Associate will benefit from ELVESYS expertise in the world fastest multiplex qPCR system to develop this first prototype. The MULTIDET project is relevant to bring a PoCT system to the market within the next couple of years. This system will bring ELVESYS to a pioneering position for multifunctional PoCT systems to solve medical and social issues of kidney diseases that weigh severely on the EU healthcare systems. This project will also allow ELVESYS to train an Innovation Associate in entrepreneurship so that they can later b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The time-course of visual, orthographic, phonological and semantic information during written word processing in skilled deaf readers: evidence from eye movements and ERPs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Learning to read is a great challenge for deaf children due to their limited access to the sounds andlimited knowledge of thelanguage they learn to read. Deaf adults’illiteracy levels aremuch higher than that of their hearing peers, but some deafindividuals can and do become skilled readers, though in a qualitatively different way than typically observed in hearingreaders. New evidence shows that relative to skilled hearing readers (SKH), deaf readers do not activate phonologicalcodes, but activate orthographic codes and show greater use of semantic informationduring word reading. Eye movementdata shows that skilled deaf readers (SKD) skip words more often, and refixate words less often than SKHreaders do. Inother words, SKDreaders are more efficient at processing words accurately within a single fixation than SKHreaders are, andthis may be in part explained by 1) faster processing of visual information, 2) more direct connections between orthographyand semantics, or 3) a combination of these two factors. This has been termed the word processing efficiency (WPE)hypothesis and the hypothesis predicts that SKD readers will show earlier activation of orthographic codes, no phonologicalactivation, and thus faster access to semantic codes compared to SKH readers. I will test this hypothesis by investigatingand comparing the time-course of word processing in SKDand SKHreaders, by 1) observing participants’ eye movementsduring reading to determine the earliest point of activation of parafoveal visual, orthographic, phonological, and semanticcodes, and 2)assessing the neural underpinnings of the WPE hypothesis with respect to the timing and types of codes withERP measures. The results will lead to empirically tested solutions for the reading development of deaf children that ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Christians among Muslims in Medieval Egypt'.

assistant: **Concept**

The CaMMEgy project aims at studying the adaptation processes of the Coptic Christian population after the Arab conquest of Egypt (642 CE) under an innovative angle. It will focus on discourse strategies set up by members of this community in order to claim and reinforce a favourable position in a social and territorial context that was gradually reorganized by Muslim rulers.The analysis will be based on data extracted from two largely understudied textual corpuses that are rarely mobilized together. The first corpus is the Coptic-Arabic historiography and is constituted by historical texts written in Arabic in a Coptic ecclesiastical milieu after it had been arabicized, from the 11th century onwards. The second corpus – papyrological sources – consists mainly of fiscal, legal and epistolary documents, mainly written in Arabic (but also Greek and Coptic). As products of daily interactions between the various members of the Medieval Egyptian society, they will allow to assess the historical reliability of data coming from the first corpus and to consequently highlight the abovementioned strategies. The research will be interdisciplinary and will combine the historical approach, led by Prof. Mathieu Tillier (the supervisor), with the perspectives of textual criticism, (socio)linguistics and literary analysis, provided by Dr. Perrine Pilette (the experienced researcher), at the Université Paris-Sorbonne.Next to peer-reviewed articles that will be uploaded on an open-access repository at the date of publication, one of the main outputs of the CaMMEgy project will be intended for the use of both the academic and general public: new geo-historical maps of Egypt and the Coptic territory – real or purported – will be drawn and uploaded on an open-access web platform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Impact of IL-7 and IFNa on nTreg development' (3ITD) under Seventh Framework.

assistant: **Objectives**

In developed countries, most HIV-infected patients are under highly active antiretroviral therapy (HAART). However, despite controlled viral replication, the immune reconstitution often remains incomplete, probably due to a poor reconstitution of thymic production. Apart its role in educating a diverse repertoire of conventional T-cells, the thymus also produces natural regulatory T-cells (nTreg), which contributes to the regulation of immune responses. Various cytokines are presently proposed as immunotherapy susceptible to help reconstituting circulating T-cell pool. Among these, Interleukin-7 is certainly the more promising as it directly affects thymic function, allowing T-cell neo-production and thus the enlargement of circulating T-cell repertoire diversity. The 3ITD project aims to a) analyze the physiology of nTreg production by the thymus; b) precisely evaluate the impact of acute SIV infection on nTreg production and identify the cytokines involved in early thymic defects; c) realize a pre-clinical study using recombinant IL-7 as a potential therapeutic to reconstitute nTreg subset in chronically HIV-infected patients and in HIV/HCV co-infected patients presenting with IFNα therapy-induced lymphopenia. The 3ITD project will be developed in 3 stages: a) definition of the phenotype of nTregs recently emigrated from the thymus; b) estimation of the impact of acute SIV infection and IFNα therapy; c) evaluation of the relevance of IL-7 treatment. The 3ITD project will provide a better understanding of the physiology of nTregs maturation by the thymus and of the modifications induced by HIV infection. Moreover, the 3ITD project will provide pre-clinical rationale for the use of IL-7 as a therapeutic compound in the treatment of virally- or pharmaceutically-induced n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Weak interactions in self-organizations studied by NMR spectroscopy in the supramolecular solid-state'.

assistant: **Concept**

Self-assembly is a fundamental process by which individual subunits organize into ordered supramolecular entities, usually through weak interactions. A longstanding goal is to engineer synthetic self-organized structures, often inspired by protein assemblies found in the context of living cells, to design materials of high potentiality, e.g. drug delivery, scaffolding or electronic applications. There is a tremendous interest in physical chemistry to understand the role of weak interactions at the supramolecular interfaces. However, self-organizations usually form soft material, lacking crystalline order and at the same time exhibiting poor solubility. As a consequence, standard techniques for structural investigation such as X-ray crystallography or solution NMR usually fail or deliver only partial information, preventing an atomic-level understanding and therefore the design of new architectures. The Weakinteract project aims at developing NMR spectroscopy in the relevant supramolecular solid-state for those non-crystalline and insoluble self-organizations. Weakinteract will exploit strategic isotope labeling, state-of-the-art solid-state NMR methods and integration of hybrid approaches to elucidate the assembly mechanisms, revealing the weak interactions at the supramolecular interfaces. The project comprises three different aspects of growing complexity: (1) Elaboration of a proof-of-concept for atomic resolution structure determination of self-assembled nanotubes in hydrogel form. (2) Determination of the structural basis for bacterial filaments (3) Investigation of the phenomenon of heterogeneous supramolecular templating, in the context of amyloid fold initiation. One major aim of Weakinteract is to provide a robust approach dedicated to chemists, biophysicists a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SENSING CELL-CELL INTERACTION HETEROGENEITY IN 3D TUMOR MODELS: TOWARDS PRECISION MEDICINE' (INTERCELLMED).

assistant: **Concept**

This project aims to investigate the role of potassium (K+), protons (H+) and oxygen (O2) gradients in the extracellular space of tumour cells grown in 3D cultures by using a combination of imaging, cell biology and in silico analyses. By embedding ratiometric fluorescent particle-based sensors within 3D scaffolds, the changes in target analyte concentrations can be monitored and used to study the interactions between tumour cells and stromal cells in 3D tumoroids/scaffolds and to monitor response of the cells to drug treatments. I first demonstrated successful fabrication of barcoded capsules for multiplex sensing of H+, K+, and Na+ ions. Next, I demonstrated the use of pH-sensing capsules as valid real time optical reporter tools to sense and monitor intracellular acidification in living cells. Thus, I can fabricate capsule sensors for investigating the role of key analytes that are involved in regulation of crucial physiological mechanisms. In addition, I successfully integrated pH-sensing capsules within 3D nanofibrous matrices and demonstrated their operation under pH switches. INTERCELLMED will engineer 3D scaffolds that do not only sense extracellular pH but are also able to sense K+ and O2 changes. To this aim, a novel set of anisotropic analyte-sensitive ratiometric capsules will be developed and applied for generating robust and flexible capsules-embedded sensing scaffolds. To validate the functions of the 3D sensing platform, cocoltures of tumour cells and stromal cells will be grown and their interaction and response to drug treatments will be studied by mapping the K+/H+/O2 gradients in and around the cell aggregates. Finally, the 3D sensing platform will be adapted for growing tumour tissue-derived cells that will be tested ex-vivo with anticancer dugs. Sp