RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improved Millets for Phosphate ACquisition and Transport' (IMPACT), addressing dissemination and exploitation.

assistant: **Impact**

Phosphorus is an essential plant nutrient and is limiting for crop yield on up to 40% of arable land worldwide, including Europe. The major scope of current proposal is the exploitation of strategies to improve the phosphate use efficiency of a key crop, foxtail millet (Setaria italica). Several families of membrane transport proteins are involved in the uptake of Pi from soil and its distribution within the plant. These transport proteins are referred as Pht1. In this study we propose to characterise the Pht1 family of Seteria italica and determine whether manipulation of expression level or affinity for substrate is a useful approach for improving phosphate use efficiency. Molecular approached involved in this study include gene expression studies of the phosphate transporter (Pht1) family from foxtail millet (Seterica italica), construction of a homology models of all expressed SiPht1genes, down regulation of the major low P inducible root and shoot transporters by RNAi, cloning the most significant members of this family and confirm their function by expression in heterologous systems. Site directed mutagenesis guided by the homology model will also be performed to identify important residues. Finally, millet will be transformed with wild type and selected mutants and tested for the performance on different phosphorous regimes. This study underpins the efficient phosphate usage in foxtail millet and help to improve the yield in other crops by utilizing the technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Influence of rain microphysics on soil erosion processes' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Soil erosion has been recognized to be governed by rainfall characteristics (rainfall intensity, drop size distribution, drop velocity in various combinations), among other factors (soil structural composition, vegetation cover, soil surface slope). The aim of these proposal is to study the relationships between the rainfall characteristics measured with the improved OSP (Optical Spectro Pluviometer) on one hand and splash detachment rates, structural changes of the top soil and the related infiltration response on the other hand. Objectives are i) a better prediction of the erosion rates and the hydrological response of various soils and soil surface states when subjected to rains of various characteristics and ii) the development of a physically-based model predicting splash detachment rates and rates of physical soil degradation under rain. Using the OSP to study erosion processes under rain offers unprecedented possibilities and opens the perspective to extend the fields of application of the OSP from surface hydrology toward soil degradation studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Neuroprotective human antibodies to the flexible tail of the prion protein'.

assistant: **Objectives**

The misfolding of the cellular prion protein (PrPC) causes infectious neurodegenerative conditions called prion diseases. In the framework of the ERC-funded study “The Prion Protein in Health and Disease” the team of Adriano Aguzzi has discovered that antibodies against the flexible tail (FT) of PrPC are neuroprotective against prion pathologies. Here we propose to clone and express such antibodies from humans and to develop them as antiprion therapeutics. The principal investigator has founded a company (www.Mabylon.com) which has established a high-yield method for cloning paired heavy and light chains from human memory B cells. The proposed research program will identify rare anti-FT immunoreactive individuals among large populations by high-throughput screening. The clinical information of the selected individuals will help to identify antibodies from persons devoid of pathologies that may be related to anti-PrPC autoimmunity. Therefore, the human antibodies generated within this program will represent fast-track investigational new drug (IND) candidates with safety profiles superior to those of murine or humanized antibodies. Completion of the proposed activities will lead to the development of therapies against prion diseases, which are currently considered untreatable and invariably fatal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Samurai - Platform detecting and preventing cyber violence' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cyber violence is an increasingly growing concern among children and adolescents. Number of children admitted to hospitals for attempted suicide or expressing suicidal thoughts doubled between 2008 and 2015 - much of the rise is linked to an increase in cyberbullying. Problem conerns also adults - EU estimates that 1 in 10 women have experienced some form of cyber violence. Online violence causes a massive outflow of portal and game users - more than 20% of players left the game due to cyberbullying and 35.8% of women quit playing temporarily because of sexism. These kinds of actions results in a significant reduction of revenues for entities in the industry. Therefore, the health and economic implications of cyber violence provide a compelling multimillion business opportunity. Fido has developed a game-changing Samurai system, artificial intelligence solution dedicated to real-time, automated prevention of online violence in text communication, based on a novel patent. The recent studies show that that our technology detects the most violence and raises false alarms four times less often than the current solutions.Fido main customers are game industry players, communication/education platforms and social media. During the first 5 years of commercialisation of Samurai we expect to generate EUR12,7 m in turnover and hire additional 18 workers. Fido Voice is a high-tech Polish SME, supported by business angels, specialising in artificial intelligence and natural language understanding. Our technology was recognised as one of the 100 most promising artificial intelligence solutions  in the world (Top 100 AI CBInsights 2017). The founders of Fido were chosen one of Top 100 Innovators Group awarded by Google and Financial Times.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nonlinear Excitation of Ideal Anapoles' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Anapoles are nonradiating states of light, in which optical fields are trapped by destructive interference of outgoing radiation. They have recently attracted significant interest due to their potential in resonant nanoscale light confinement, which could be used in lasers, sensors, quantum computers and other areas of light-based research and technology. However, ideal anapoles have never been experimentally achieved, because making them perfectly decoupled from external radiation would prevent their excitation and observation. The proposed project will resolve the above issues. Advanced theoretical modeling tools will be used to design the ideal anapoles that can be excited through second-harmonic generation. In this process, the incident light would illuminate the anapolar nanoresonators and nonlinearly induce local optical fields matching the anapole's excitation at twice the incident light frequency. Second-harmonic optical fields may form configurations that can not be induced through linear interactions with external optical fields, hence allowing these local fields to be fully decoupled from external radiation. These local nonradiating fields will then induce photoluminescence at optical wavelengths detuned from the anapole's resonance. Detecting this photoluminescence will enable probing the anapole excitation. To demonstrate this concept in experiments, resonant photonic samples will be fabricated in the silicon nitride (Si3N4) material platform, integrated with molibdenium disulfide (MoS2) monolayers which can simultaneously support efficient second-harmonic generation and photoluminescence. The samples will be excited by time-controlled ultrashort laser pulses, enabling investigation of the temporal dynamics of the anapole's local optical fields and retrievi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Spatiotemporal organisation of bacterial outer membrane proteins' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The outer membrane (OM) of Gram-negative bacteria protects against environmental insult and is central to pathogenesis hence finding ways to disrupt its integrity is a route towards new antibiotics. However, our understanding of OM biology is limited. In particular, how the OM is organised is largely unknown. My laboratory recently discovered spatiotemporal Outer Membrane Protein organisation (OMPorg) in Escherichia coli, a new organising principle that explains how OMPs are turned over. We found that OMPs cluster into islands that can be mimicked in supported bilayers using purified proteins. As cells grow, OMP islands are displaced to the poles by new islands, leading to binary partitioning of old OMPs in repository cells following septation.Another poorly understood aspect of OM biology is how protein bridges that connect the OM to the inner membrane (IM) mediate functions across the periplasm. We have discovered that the characteristic immobility of OMPs in vivo, caused by OMP clustering, becomes imposed on IM proteins (IMPs) when OMPs and IMPs become connected by protein bridges.These exciting new findings underpin OMPorg. I will focus on two species, E. coli and P. aeruginosa, and exploit the tools I have developed to ask four interrelated questions:1. What is the molecular basis of OMP island formation?2. Do OMPs influence IMP functionality via protein bridges?3. Do repository cells endow bacterial populations with ‘OMP memory’?4. Do OMP islands coordinate OM processes?I will address these questions through an interdisciplinary research programme incorporating protein chemistry and proteomics, ensemble and single molecule microscopy on live cells and in supported bilayers and molecular dynamics simulations. OMPorg will answer major outstanding questions concernin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '5G Enablers for Network and System Security and Resilience' (5G-ENSURE) targeting Horizon 2020.

assistant: **Abstract**

5G-ENSURE will define and deliver a 5G Security Architecture, shared and agreed by the various 5G stakeholders. It will specify, develop and release an initial set of useful and usable security enablers for 5G. These enablers will be selected for their relevance in addressing some of the foremost security concerns in order to generate the trust and confidence necessary for 5G to be widely adopted and to deliver its promises through innovative business applications. The 5G-ENSURE project will also initiate a 5G Security testbed vision and initial set-up in which the security enablers will be made available. Moreover, the potential of the developed 5G Security enablers will be showcased and demonstrated in the context of carefully selected 5G security use cases (e.g. use cases related to cybersecurity and aerospace).Coupled with this, 5G-ENSURE will be closely linked to the overall 5G PPP programme through active participation in common activities and fora. Specifically, 5G-ENSURE will be the project that creates and animates a dedicated 5G PPP Security Working Group to coordinate the various security-related activities.5G-ENSURE is led by a strong consortium bringing together the appropriate and complementary skills, including standards involvement and deep telco understanding, along with an extensive network of interested parties, and have a proven track-record in coordination.  5G-ENSURE will avail itself of the support of a group of international opinion leaders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nuclear HuR-hnRNP interactions in post-transcriptional regulation of inflammatory gene expression' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Inflammation, essential component of the innate immune response, allows multicellular organisms to repair damaged tissue. Excessive inflammation however, can itself exacerbate tissue damage, leading to chronic inflammation-related disease. The expression of crucial mediators of the inflammatory response is tightly regulated at transcriptional and post-transcriptional levels. Recent studies have shed some light on how cytoplasmic RNA processing events regulate mRNAs encoding inflammation mediators. However, it is unknown how nuclear post-transcriptional events control the expression of such molecules and what the contribution of RNA binding proteins (RBPs) in this control is.An RBP that has emerged as a pleiotropic modulator of mRNA function is HuR (Human antigen R) protein. In the cytoplasm, HuR stabilises many mRNAs via interplay with other RBPs. Research from the host laboratory has shown that over-expressed HuR represses translation of specific inflammatory mRNAs and attenuates acute inflammatory reactions, an unexpected role for HuR given its previous characterisation as an mRNA stabiliser. However, the role of HuR in the nucleus, where is most abundant, is still not understood. What is known is that nuclear HuR interacts, in an RNA dependent manner, with certain hnRNPs known to play a role in post-transcriptional regulation of gene expression. However, the role of these nuclear HuR-hnRNP interactions is unclear.The proposed research aims to understand the role of the nuclear HuR-hnRNP complexes in post-transcriptional regulation of inflammatory response in mouse macrophages. The Researcher’s expertise in studying ribonucleoprotein interactions in RNA function and processing in vitro will be combined with the Supervisor’s in functional study of post-transcriptional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Constructing a geometric algorithms library' under Fourth Framework.

assistant: **Concept**

The ultimate goal of the CGAL project is to make the large body of geometric algorithms, developed within the field of computational geometry, available for industrial application. To this end the project will follow three paths.We will develop a C++ library named CGAL (pronounce seagull") that consists of a kernel of geometric data types and operations, a collection of geometric algorithms for both 2-dimensional and higher-dimensional problems, and a support library for visualisation and I/O. The library must be robust, efficient, general, and easily maintainable.The consortium will co-operate with ten industrial collaborators on the applicability of CGAL in their work on geographic information systems, visualisation and simulation, CAD/CAM, and shape analysis and reconstruction.The project consists of theoretical and experimental research on implementation aspects of geometric algorithms.The expected deliverables are first implementations of data structures and algorithms, and study the applicability of CGAL in the application domains.The CGAL project will be carried out by a consortium of seven sites: Utrecht University (The Netherlands, prime contractor), ETH Zürich (Switzerland), Free University of Berlin (Germany), INRIA Sophia-Antipolis (France), Max-Planck-Institute Saarbrucken (Germany), RISC Linz (Austria), and Tel-Aviv University (Israel). These are leading sites in the area of computational geometry, and also have ample experience with the implementation of geometric algorithms and with the application of these techniques to problems in the various application domains.The partners will closely collaborate with the following companies:NOESIS (France), Thomson Training and Simulation (France), Matra Marconi Space (France), Mental Images (Germany), Isys Softwar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of active, intelligent and sustainablefood PACKaging using PolybutyleneSUCCInate""'.

assistant: **Objectives**

SUCCIPACK aims to support European industry efforts to introduce biobased polybutylene succinate (PBS) as a new material on the food packaging market. Its main advantage is that it has complementary properties compared to other biobased polymers like polylactic acid. PBS is synthesized by polycondensation of succinic acid and butanediol, both identified as key “building blocks” from renewable resources which will be produced on a large scale in the coming years.The aim of SUCCIPACK is to develop sustainable, active, and intelligent food packaging materials based on green PBS that can be flexibly used by packaging and food industries. A first aspect is the optimization of the synthesis and compounding of polymer and copolymer grades for industrial plastic transformation processes to obtain films, trays and pouches. Tailored packaging functionalities will be obtained by flexible in-line surface treatments to control gas barrier properties and to introduce antimicrobial activity. The performance and safety of the novel packaging materials will be assessed for selected food products, representative of different food categories and preservation technologies. Special efforts will be put to explore PBS recycling routes, including chemical recycling by monomerization. An original intelligent labeling function will be added to monitor material degradation and recondensation, during shelf life and recycling. Life cycle assessment (LCA) and life cycle cost analysis (LCC) will be applied to guide the material development and to assess the sustainability of the whole packaging concept.SUCCIPACK will help European industry, especially SMEs, to strengthen their competitive advantage over the currently fast growing green PBS developments in the US and Asia. The cooperation between 7 re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification of the protein binders of the androgen receptor BF3 pocket, an allosteric modulator of AF2 coactivator recruitment' to be submitted under Seventh Framework.

assistant: **Abstract**

The androgen receptor (AR) is a nuclear receptor (NR) that plays a central role in prostate cancer. The transcriptional activity of AR can be modulated though a newly described regulatory surface on its ligand binding domain (LBD). We call this surface BF3 (binding function 3), and I discovered it during my postdoctoral research. So far the only coregulatory proteins described are able to regulate AR activity by binding to the coactivator binding pocket (AF2), which is also located on the LBD surface. Both pockets, AF2 and BF3, are physically connected. In my numerous molecular structures of the AR LBD solved by Xray crystallography, I have been able to see that BF3 is an allosteric modulator of AF2. BF3 is able to influence whether coactivator proteins are correctly recruited to AF2 to start the transcriptional cascade of AR-dependent genes. Thanks to my discovery of several BF3-interacting chemical compounds we have been able to determine which conformational changes are propagated from BF3 to AF2 impairing AR activity. Such small molecules are an important starting point for structure-based drug design to identify novel AR regulators that may be used as new treatments for prostate cancer. I have also investigated what effect mutations in BF3 have on AR transcriptional activity. The topology, localization, and physico-chemical properties of BF3 indicate that it is a bona fide pocket for protein-protein interactions and it may have a physiological regulatory action on AR function in vitro and in vivo. The identification, characterization and crystallization of BF3-interacting proteins and their crystal structure determination alone or in complex with AR are the main objective of my future research. Such proteins may be a novel class of AR coactivators in particular, or