RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Confident®, the digital simulation platform that revolutionizes cardiovascular interventions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Confident is a disruptive cloud-based platform for digital planning of cardiovascular interventions. Today, many patients do not have access to treatment as their case is considered at too high risk for surgery. Created in 2017, PrediSurge has developed a unique AI-based solution that enables physicians to select the best therapeutic strategy for a specific patient.Confident®builds 3D virtual models of patients’ anatomy and implants with real-life biomechanical behavior. For the 1st time, physicians can simulate procedures to predict and prevent post-operative complications. Our patented digital twin technology completely redefines planning potentialities of endovascular aneurysms repair and transcatheter mitral valve repair.With EIC, PrediSurge will accelerate its business development to become a world leader in predictive software solutions for cardiovascular precision medicine. We will digitalize cardiovascular healthcare to change the lives of millions of patients.


**Keywords:** biomechanics,medical imaging,machine learning,signal processing,modelling algorithms,scientific computing,Advanced computing,chronic disease,Cardiac and Cardiovascular systems,preventive medicine,predictive medicine,aortic repair,endovascular interventions,minimally-invasive procedures,stent-grafts,Medical devices,Digital services,numerical simulation,digital twins,digital health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'NEONATAL KIDNEY STEM PROGENITOR CELLS AS A NOVEL TYPE OF CELL THERAPY'.

assistant: **Objectives**

Global mortality from chronic kidney disease (CKD) is estimated at more than 1.2 million annually. CKD is caused by the irreversible loss of nephrons, the structural and functional units of the kidney. Lineage tracing revealed that all renal cells are derived from a SIX2+ embryonic progenitor population originating at the cap mesenchyme (CM). SIX2 is essential for cells’ self-renewal, and its cessation signals the initiation of nephron differentiation. However, SIX2+ progenitor cells are exhausted in the mature kidney.  My team has recently discovered a novel unique source of kidney stem/progenitor cells (nKSPCs) derived from the urine of neonates born before the completion of nephrogenesis. nKSPCs express SIX2 as well as  various other CM progenitor markers, and they show a high capacity to differentiate into functional kidney epithelial cells. Additionally, our data show that nKSPCs have an immunomodulatory capacity in vitro. Using normothermic machine perfusion (NMP) of human kidneys, we have discovered that nKSPCs are able to reduce inflammatory responses and activate regenerative processes. Building on these findings, I aim to establish nKSPCs as a potent novel cell type for the development of kidney-targeted cell therapy for preconditioning kidney allografts prior to transplantation. To this end, I will elucidate the immunomodulatory profile of nKSPCs and demonstrate their potential for engraftment and regeneration at single cell level using advanced methodologies for the first time in this field. Moreover, I will use the ground-breaking pre-clinical platform of whole organ culture system to trace single nKSPCs in kidney tissue over a longer period of time after injection. nKSPCs are an unexplored progenitor cell type, which might revolutionize the field of kidney
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart information, governance and business innovations for sustainable supply and payment mechanisms for forest ecosystem services' under Horizon 2020.

assistant: **Concept**

The objective of InnoForESt is to spark a transformation of the European forest sector by stimulating innovations for the sustainable supply and financing of forest ecosystem services. The project will support the governance of viable innovations and a multi-actor network by building on pioneer policy tools and business models, by establishing new alliances, and by involving key stakeholders from forest and forest-related policy, administration and business. InnoForESt will establish six real world pilots that represent a range of successful coordination approaches and business models. The project will facilitate the transfer and up-scaling of existing niche models identified and the development of new innovations, to demonstrate the feasibility of alternative income streams from a diverse set forest ecosystem services. The case study regions represent a variety of biophysical conditions and institutional settings across Europe. The core elements of InnoForESt are: (i) multi-actor networks, (ii) digital and physical innovation platforms, (iii) facilitated innovation processes for business and policy making, (iv) information generation and support for future national and EU forest policy making. Within the networks, stakeholders will exchange ideas, knowledge and practices. InnoForESt has already engaged a broad set of practice partners to establish the core of the networks. The innovation platforms will function as hubs and as spaces for exchange and learning. The project will scale up the results to the European level, making use of the thorough understanding of Europe’s social-ecological landscape as well as sustainability impacts of different governance mechanisms. The lessons will feed into a roadmap for the provision of forest ecosystem service bundles and a broad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Decarb City Pipes 2050 - Transition roadmaps to energy efficient, zero-carbon urban heating and cooling'.

assistant: **Concept**

Climate urgency calls on all political levels to act more stringent and faster. This proposal is the first to unite cities across Europe to work out actionable, spatially differentiated transition roadmaps to decarbonise heating and cooling for buildings in 2050, taking up the challenge to phase out natural gas in heating.Transitioning the sector to energy-efficient, renewable and zero-carbon solutions is key to meet the EU climate and energy targets. Given the long life-cycles of the grid infrastructures involved, there is an urgency to start the planning of this transition today. But how? What first? Which systems? How to govern this process? Increasing complexity of the energy system together with technological uncertainties require a high level of knowledge and skills to act wisely. Cities are ill-equipped for this. They lack capacity and skills as well as legal empowerment to act. Decarb City Pipes 2050 showcases how local authorities can succeed in this challenge. Bilbao, Bratislava, Dublin, Munich, Rotterdam, Vienna and Winterthur, seven cities from frontrunners to beginners join forces to learn from each other and elaborate innovative responses together. They explore pathways suitable for their local challenges and build up skills in the use of data, planning tools and instruments, techno-economic as well as process and transition management knowhow. In a participatory process with stakeholders, they develop tangible transition roadmaps, building up trust and commitment for its implementation along the way. In deep peer-to-peer exchanges, cities and utilities share knowledge to benefit from other perspectives, stages of advancement and planning traditions. Together, they will advocate for the needed changes to framework conditions.Enriched by a distinguished adv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a novel autonomous vehicle significantly reducing costs related to subsea sensors deployment and recovery' (AUTODROP) targeting Seventh Framework.

assistant: **Abstract**

There is a distinct need for an improved method for accurate and inexpensive deployment and retrieval of seabed sensors and equipment. The AutoDrop will be hydro dynamically designed in order to glide through the water experiencing a minimum of drag. The rudders will maintain stability and change the direction if desired. It is important that the time used by the AutoDrop to travel from the surface to the seabed is kept at a minimum to maximize accuracy. A short time descending requires a heavy weight load attached to the unit, while releasing the weight load should lead to high degree of buoyancy to enable rapid ascent. Manner of operation: Prior to deployment operation, the units are programmed with a destination on the seabed and a location on the surface. The unit uses the surface location as a reference in order to navigate to the target area. As the unit is dropped into the water, it gains momentum until terminal velocity is reached. The navigation system calculates the position of the unit relative to the target and, if necessary, adjusts the rudders to change direction. A gentle landing further increases the chances of a successful deployment. The sensors transported down to the seabed by the AutoDrop units perform their task over a defined time period. When it is time to ascend, either dictated by a programmed time limit or by a broadcasted signal from top side, the AutoDrop units release their weight load or in other ways change their buoyancy. The buoyancy causes the units to ascend towards the surface. The navigation system will be applied on the way up and may be programmed to form clusters on the surface, thus simplifying the retrieval process. Clusters are easy to form by sending a number of units to the same surface location. At surface the AutoDrop unit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'AFRICA BUILD (Building a Research and Education Infrastructure for Africa)', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Topic: AFRICA BUILD aims to improve capacity for health research and education in Africa, through Information Technologies (IT). It will provide innovative learning and research opportunities.Background: The EU has supported many IT and health initiatives, with significant results. In contrast, there has been no significant transfer of expertise, methods and tools to neighbour countries in Africa.Main objective: To promote health research, education and practice in Africa through the creation of centres of excellence, by using IT, “know-how”, e-learning and knowledge sharing through Web-enabled virtual communities. Initial EU-Africa transfer aims to create sustainable South-South communities of African researchers.Sub-objectives:(1) To analyse the state of the art in health research and education in Africa. A Roadmap for future European actions will be released.(2) To implement an IT-enabled, open and collaborative infrastructure for education, training and knowledge sharing for health researchers in English-, French- and Arabic-speaking African countries, developing virtual communities of practice.(3) To develop and offer a large number of e-learning courses, validated learning resources, methodologies and supporting evidence for improving the education capacities of health-focused centres of excellence in Africa.(4) To facilitate researchers’ mobility and participation in local and international meetings.(5) To validate the AFRICA BUILD impact in pilot research and education initiatives related to reproductive health and HIV/AIDS research.(6) To disseminate outcomes in scientific conferences and journals, media and workshops and conferences in Africa.Expected impact: Based on the experience of the partners —including WHO— we aim to improve know-how, research and techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Horizon 2020: H2020-SGA-INFRA-GEANT-2018 Topic [b] Increase of Long-Term Backbone Capacity' to be submitted under Horizon 2020.

assistant: **Abstract**

The GN4 Phase 3 Network (GN4-3N) proposal for part b of the third Specific Grant Agreement (SGA3(b) is made in response to the H2020-SGA-INFRA-GEANT-2018 (Topic [b] Research and Education Networking) call, received 17 October 2018, under the 68-month Framework Partnership Agreement (FPA) established between the GÉANT Consortium and the European Commission in April 2015.  It is  proposed to last 48 months to implement, as the call requests, a very ambitious restructuring of the backbone network operated by GÉANT in order to provide equal access to clouds and other e-infrastructure services in the European research area and beyond.  It will improve the overall resilience and reliability of the GÉANT network significantly and offer a base for future improvements in access, transmission speeds and capacity wherever needed.The outcome of GN4-3N project will offer uniform network access and choice of services to many more partners, eliminating the ""digital divide"" wherever technically and economically feasible. This project proposal is based on technical and economic studies carried out during 2017-2018 in the GN4-2 project which have given the Consortium clarity on the resourcing, financial and effort, needed to realise the huge ambition of this undertaking.  It exclusively covers the engineering, procurement, acquisition and installation of the new backbone network. The day-to-day network operations as the elements of it is commissioned is the responsibility of the teams described in accompanying the GN4-3 project.The GN4-3 and GN4-3N proposals are intimately connected through common teams and the technical, management and procurement expertise built-up over previous GN projects. This is what makes this ambitious proposal realistic. GN4-3N and GN4-3 have simply had to be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Overweight-induced Hypogonadism as major factor for the generation and/or perpetuation of Metabolic Co-morbidities of Obesity: Contribution of Epigenetic Regulatory Mechanisms' (ReprObesity).

assistant: **Concept**

Obesity is a global health problem whose prevalence is increasing substantially due to lifestyle changes. This complex medical condition is frequently linked to serious metabolic complications and deregulation of hormonal axes, which lead to perturbed homeostasis in conditions of overweight. Different studies have suggested that obesity is often associated to hypogonadism, a reproductive disorder that might also promote metabolic alterations, thus setting a vicious circle in the generation/perpetuation of obesity co-morbidities. While the targets and molecular mechanisms underlying this phenomenon are still unknown, emerging evidence from experimental models of metabolic stress linked to hypogonadism strongly suggests the potential role of perturbations of hypothalamic Kiss1/NKB neurons. Likewise, the recently identified involvement of epigenetics in the control of Kiss1 expression at puberty, a crucial stage in sexual development that is metabolically gated, suggests also the contribution of these regulatory mechanisms to this phenomenon. In this context, this project aims to elucidate the pathophysiological relevance of epigenetic regulatory mechanisms in obesity-induced hypogonadism and their influence in the generation/ maintenance of the metabolic complications of overweight. To this end, we will characterize the time-course of alterations of key hormonal and epigenetic factors in preclinical models of obesity and will evaluate the contribution of epigenetic modifications in deregulation of hypothalamic Kiss1/NKB neurons in conditions of overweight. In addition, we will analyse the potential role of gonadal steroids in this phenomenon. This project will help to identify the molecular targets and epigenetic mechanisms responsible for the metabolic perturbations link
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Responsible research and Innovation Policy Experimentations for Energy Transition' (RIPEET), addressing dissemination and exploitation.

assistant: **Impact**

The RIPEET project will support Responsible Research and Innovation (RRI) policy experimentations for energy transition in three European territories - in Extremadura (ES), Highlands and Islands of Scotland (UK) and Ostrobothnia (FI). The methodology builds on RRI, transformative innovation, transition management and the Multi-Level-Perspective. RIPEET brings together quintuple helix actors of the territorial socio-technical energy regime in Transition Labs in order to envisage and implement a place-based energy transition process. Building on this evolutionary model of socio-technical transitions, RIPEET will use existing landscape and regime-level pressures to facilitate the development of territorial socio-technical futures based on RRI actions. The governance and agency in this transformative process will be organised within the Transition Labs. These Labs will bring together stakeholders to co-create common visions based on the potentials and priorities of territorial eco-systems (mapping and visioning), generate transition pathways and innovation needs, launching a call for immediate bottom-up solutions to these (pathways and piloting) and anchor the process on organisational as well as policy level (sustainability and exploitation). The framework conditions, processes, and outcomes of these experiments will be mapped, monitored, and evaluated. This constitutes an evidence-base for the revision of sectoral policies, strategies and research and innovation (R&I) instruments as well as for establishing a European RIPEET community. Thereby, RIPEET will support territories in establishing experimental spaces to address the territorial dimensions of the European Green Deal. The consortium consists of 11 renowned and EU-FP-experienced universities, research organisations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'CBRNE related testing and certification facilities -  A networking strategy to strengthen cooperation and knowledge exchange within Europe'.

assistant: **Innovation**

In the 30-month project CREATIF a network of testing facilities for security related products and services focused to CBRNE detection will be established. This network is dedicated to provide a communication platform for technology users and decision makers, providers and testers to discuss the future development of testing and to support user decisions and industry product / service development. All these stakeholders are invited to become members of the network and exchange their views and knowledge: testing facilities can publish information about their expertise and testing capabilities / facilities in a database on testing facilities within EU-27, an advisory board of end-users and industrial experts will be established to integrate their point of view into project deliverables and topical workshops. In these workshops specific themes in the field of certification and testing of CBRNE detection equipment will be discussed. Proceedings will be compiled to distribute the outcome of discussions and present information to a wide audience. CREATIF will ensure a careful examination of existing testing protocols and relevant standards to suggest harmonization of testing in the field of CBRNE detection both on a geographic scale within EU-27 and on a technical level. This will allow quality assurance and comparability of testing results. Possibilities to amend testing protocols by covering human factors and operational / scenario based testing will be suggested. Additional deliverables of the network will be a roadmap for a European certification system for CBRNE detection products & services and a concept on the continuation of the CREATIF network as an autonomous body after the end of the funded project. Based upon the experience of network building within well-focused g