RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Consortium for Research into Nuclear Receptors in Development and Aging' (CRESCENDO).

assistant: **Innovation**

Nuclear receptors function throughout development and aging as molecular integrators of complex physiological regulations, such as growth, reproduction and metabolism. To translate genetic knowledge from the Human Genome into therapy requires intimate understanding of fundamental regulatory mechanisms. CRESCENDO will build on existing knowledge and infrastructures by drawing together European excellence to focus on signalling dynamics, integration of target gene responses during development and aging, and human genetics and pathophysiology, emphasising key nuclear receptors. State-of-the-art genomic and post-genomic techniques will lever advances on mechanisms and kinetics of nuclear receptor signalling in processes underlying development and aging. Information on spatial and temporal aspects of signalling dynamics will feed into a broader vision of how nuclear receptors integrate multiple inputs in whole organisms across the life span. Focus will be on developmental targets, on brain development and aging, and the complex interplay between metabolism, particularly glucose and lipid signalling, and brain function. The brain is emphasised, as its disorders often cause most distress in unhealthy aging. A strong investment in bioinformatics will facilitate data extraction from multi-level analyses (genes to cells to organisms) and accelerate determination of targets, regulatory networks and integration of physiological responses within individuals and populations. The consortium includes molecular and developmental biologists, physiologists and human geneticists, and has access to major national and transnational data banks and resources. Nuclear receptor research is being revolutionised by the combination of technological advances with novel insights into signalling proce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Heterogeneous activity underlying the control of animal behaviour by a fungus' (HeteroGENIUS) targeting Seventh Framework.

assistant: **Abstract**

One of the most dramatic examples of parasites controlling behaviour is the manipulation of ants infected by the fungus Ophiocordyceps unilateralis, causing them to bite into vegetation before dying.Most work so far has described the ant’s behaviour. I plan to study the process behind this behaviour from the fungal genome point of view. The environment experienced by the fungal parasite changes dramatically as it goes from infection to manipulation. Therefore, the transcriptome of this mind controlling fungus is expected to be highly heterogeneous. To test this hypothesis and elucidate the complex genetic mechanisms behind adaptive parasite manipulation of host behaviour I will use a single cell, whole transcriptome analysis protocol I pioneered and apply it to this emerging model. This will allow me to sample cells in different parts of the ant’s body during different phases of the lifecycle. I will combine this with LC/MS in fungal cells transferred between artificial ant environments to elucidate the fungal metabolites that are secreted in different parts within the host. Recently, it has been discovered that manipulated biting behaviour is synchronized at noon. This indicates that the fungal circadian clock might have a big influence on this parasitic behavioural control. Therefore, I will combine my findings with chronobiology to test the hypothesis if this heterogeneous activity is a function of circadian rhythm.An important additional objective of this proposal is advanced training facilitating  my transition to independence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Carbon-based nano-materials for theranostic application'.

assistant: **Concept**

Our proposal aims to carry out a systematic interdisciplinary study of carbon-based nanomaterials, such as: carbon fluoroxide nanoparticles, carbon nanotubes, graphene and nanodiamonds for advanced theranostic application. Their uptake efficiency and specific localization in biological cells depending on intentionally designed surface chemistry will be studied in details. Extremely rich physico-chemical properties of the carbon-based nanomaterials will allow their application as multi-modal bio-imaging agents. Indeed, in addition to their well-known remarkable luminescent properties, two original bio-imaging approaches based on photo-induced electrical and acoustic effects will be developed in frames of our project. Moreover, the photo-exciting sources used for the bio-imaging purpose will be simultaneously used for therapy of cancer cells and tissues containing the carbon nanomaterials. Strongly complementary research experiences of the international partners involved in this project as well as high degree of cooperative integration between them will allow a deep scientific study of the theranostic potential of the carbon nanomaterials. Finally, active participation of the Ray Technique Ltd industrial company in the project consortium will allow building of strategies for economic realizations of the innovative achievements succeeded by the partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development approach by rapid prototyping based on visual programming and software reuse techniques' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The objective of the DART Project is to achieve a substantial improvement in the software development process of Sud Sistemi Srl, especially in the phases of system specification and coding. The expected improvement should also lead to a better acceptance of the system functionality and performance by the clients and to a more extensive reuse of base software components with reduced maintenance costs. At the completion of the project, the following objectives should be met:a) reduction in the average effort necessary for the development of new applications, with standard software component reuse figures between 60% and 80%;b) reduction in the post delivery implementations of variants (50%-60% reduction of wasted effort)c) reduction in the residual errors and the post delivery maintenance interventions (a figure of about 5% is expected for corrective maintenance effort in relation to the overall implementation effort);d) reduction in the effort of administration and evolutive maintenance of the standard library (a 25% reduction is expected);e) introduction of a formal set of process and product quality metrics.With the same characteristics (number of users, product and client type) as Sud Sistemi, in Italy there are no less than another thousand companies. In Europe this number is 5 or 6 times greater. As Sud Sistemi is a qualified partner of IBM, a natural transfer environment for the experience developed through this PIE is made up of all the Software houses that are around IBM and like Sud Sistemi are oriented to converting their software production methods towards solutions that are similar to those under experimentation. Moreover, thinking of the ever increasing demand as regards personalised Client/Server products for solving niche problems, whatever the Database s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Breaking the curse of dimension in heavy-element chemistry' (PCCDX), addressing dissemination and exploitation.

assistant: **Impact**

The acute toxicity and radioactivity of actinide compounds complicate experimental studies of the “soup” of nuclear waste produced in nuclear reactors. This motivates research into computational approaches for determining molecular properties and reactivity of actinide compounds. Unfortunately, the computational resources required by standard quantum chemistry methods grow exponentially with system size, an effect known as the curse of dimension. Since the actinide-containing molecules of relevance to nuclear chemistry contain hundreds of electrons, innovative new approaches that break the curse of dimension must be developed. One such approach models many-electron molecules as collections of noninteracting electron pairs, called geminals. Standard geminal methods are inappropriate for actinide chemistry, however, and must be extended to include (i) computationally efficient ways to account for relativistic effects, (ii) correlations between electrons beyond electron-pairing effects (weak correlation), (iii) electronically excited states, and (iv) the description of unpaired electrons. Specifically, weak correlation will be captured using Coupled Cluster-type approaches, excited states are accessible through an Equation-of-Motion formalism, and open-shell extensions will use generalized quasi-particles as building blocks for the electronic wavefunction. The extended geminal models thus developed will provide the first direct, atomistic, and quantitative computational model for understanding nuclear waste reprocessing and will provide the essential insights that are needed to guide the synthesis of new actinide compounds that can be used to separate actinides from the other components in the “soup” of nuclear waste. The developed models will be robust, computationally ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A cost-  energy-efficient treatment technology to remove pharmaceutical pollutants from water'.

assistant: **Objectives**

Widely used pharmaceuticals (synthetic or natural chemicals found in prescription medicines, over-the-counter therapeutic drugs & veterinary drugs) are finding their way into the drinking water supply via wastewater treatment facilities, posing serious threats to public health globally. The problem is that modern wastewater treatment facilities are not designed for effective removal of pharmaceuticals or similar organic compounds. Upcoming EU legislation will make such removal mandatory.Pharem Biotech brings to market PFS—the first patented enzyme-carrying filtration system capable of removing a large range of organic pollutants (pharmaceuticals and other biological active compounds such as bisphenol A, antibiotics, hormone disruptors, etc.). PFS is a filtration solution that can be easily installed at most of wastewater treatment facilities. Its compact size makes it particularly useful for urban wastewater treatment plants.  PFS is based on modified enzymes which are 200 times more effective than native enzymes, resistant to low temperature, resistant to low pH and with high levels of stability and activity. Compared to alternative purification methods, PFS is very cost-efficient, and requires no energy to run.As the total EU yearly investments in its wastewater treatment facilities and related infrastructure are expected to reach €25bn per year in 2015-2020, Pharem Biotech is addressing the market of 70,000 facilities in EU processing 100bn litres of water per day in total. During a successful Phase 1 project, Pharem Biotech validated the market and commercial feasibility of PFS, and selected the trial cases to validate the technology as well as key target markets to approach. In this Phase 2 project Pharem Biotech will industrialize PFS, validate it in trial cases a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Low cost SIGE microstructures'.

assistant: **Objectives**

The proposed project attempts to investigate routes for reducing the overall production costs by introducing novel and comparatively cheap process methods, like laser induced rapid solidification techniques, magnetron sputtering, and modified chemical vapour deposition methods.The expected results of this project will be the development of alternative methods such as: Pulsed Laser Assisted Epitaxial Deposition (PLAED), Pulsed Laser Induced Epitaxy (PLIE), Magnetron Sputter Epitaxy (MSE), Low Energy Plasma Enhanced Chemical Vapour Deposition (LEPECVD) into techniques for state of the art SiGe heteroepitaxy for high speed devices, like modulation doped field effect transistors (MODFETs). Moreover the production of high quality graded SiGe buffer layers, by means of these techniques, is also expected to substantially lower the costs for the realisations not only of SiGe MODFET devices but also of Si/SiGe multiquantum wells for optical and optoelectronic applications.Despite the first promising results, the quality of the SiGe structures realised so far with the novel methods must be further improved before attesting the suitability for electronic devices. At the moment, it is impossible to discriminate if the encountered structural problems and a sufficient control of doping profiles can be solved or whether it may represent an intrinsic limitation of the proposed novel methods.At the end of the first phase the expected deliverables are high quality epitaxial SiGe microstructures suitable for electronic device applications with particular attention to the realisation of SiGe alloy buffer layers.The specified criteria which the SiGe microstructures should fulfil to become candidates for device fabrication are: a low density of threading dislocations (<106 cm-2) and rather s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Design of Hyper Tall Onshore Wind Turbine Towers' (2014-2020).

assistant: **Innovation**

HYPER TOWER is a very promising project that will lead to a radical increase in the wind turbine tower height and consequently to an increase in the energy potential harvested by wind structures. The project reaches its aims of constructing taller, more robust and economical towers by realizing 6 work packages that are formulated and developed in 2 years. In approaching the ""20-20-20"" targets, more and more energy has to come from sustainable energy sources and since ""The taller the wind tower is, the greener the energy is"", a constant trend of taller wind energy structures is observed. The civil engineers' challenge of constructing taller structures, with heavier machinery hanging at greater heights has led to the need of evolution of a new tower configuration that can reassure the structure's robustness along with a feasible construction schedule.Hyper Tower proposes the elaboration of a new-age tower cross-section and construction methodology, which are elaborated within the project's work packages. Assessment of existing tower configuration is performed, the proposal of a new-age tower section is elaborated, numerical and experimental results are assessed and compared to traditional tower configuration results and the final tower configuration is formulated.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European process effectiveness, efficacy and efficiency improvement tools dedicated to smes' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The proposed Accompanying Measure aims at preparing a large scale research and deployement project for FP6, which will address process improvement issues in three key sectors (car, aeroplane and agrofood). Based on a close involvement of large industrial groups and their SME technology providers, an expert panel made of industrial representatives will validate a European training cursus of process improvement managers, an accreditation system for the training organisations, a ERP-like software tool to Support improvement projects and a data base organisations for practice sharing by industrial enterprises. A field validation of the project will follow with a network of 150 industrial companies built in a previous work with the EC (contract G1MA-CT200l-00007). Road maps for training and technology deployment aiming at better process stability will be defined as well as the funding needs of the whole proqramme, possibly as an Integrated Project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Searching for the Approximation Method used to Perform rationaL inference by INdividuals and Groups' (SAMPLING).

assistant: **Innovation**

Over the past two decades, a wave of Bayesian explanations has swept through cognitive science, explaining behaviour in domains from intuitive physics and causal learning, to perception, motor control and language. Yet people produce stunningly incorrect answers in response to even the simplest questions about probabilities. How can a supposedly Bayesian brain paradoxically reason so poorly with probabilities? Perhaps Bayesian brains do not represent or calculate probabilities at all and are, indeed, poorly adapted to do so. Instead the brain could be approximating Bayesian inference through sampling: drawing samples from its distribution over likely hypotheses over time. This work aims to put meat on the bones of this hypothesis by identifying the kinds of algorithms used by the brain to draw samples. Previous proposals of simple sampling algorithms both do not match human data, nor scale well to more complex probability distributions and hypothesis spaces. In our first work programme, we will investigate advanced algorithms that have been developed in computer science and statistics, to see which one is employed by the brain to draw samples.A catalog of reasoning errors has been used to argue against a Bayesian brain, but only with infinite samples does a Bayesian sampler conform to the laws of probability. In our second work programme, we will show how with finite samples the sampling algorithm we identify systematically generates classic probabilistic reasoning errors in individuals, upending the longstanding consensus on these effects. In our third work programme, we will apply the algorithm to group decision making, investigating how the sampling algorithm provides a new perspective on group decision making biases and errors in financial decision making, and harne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dependency of future climate projections on South Atlantic heat and salt transport modulated by interocean exchanges' (CLIMSATE).

assistant: **Concept**

The Atlantic Meridional Overturning Circulation (AMOC) is a complex system of upper and deep ocean currents that redistributes heat between the Southern and Northern Hemisphere. Changes in the AMOC modulate European and global climate, and represent a key uncertainty for future climate projections. Over the last decades, climate scientists have related changes in the AMOC mainly to oceanic changes in the Northern Hemisphere, though there is increasing evidence for additional Southern Hemisphere origins. Conceptual studies with numerical ocean models and paleoclimate records suggest that changes in the South Atlantic heat and salt transport due to altered exchange processes with the Indian and Pacific Ocean can impact the strength and stability of the AMOC. However, it is unclear how these processes are represented in current climate models.The overall goal of CLIMSATE is to unravel how future climate projections depend on the simulated heat and salt transports in the South Atlantic, with a focus on the role of interocean exchange processes. To achieve this, I will develop an advanced framework for analyzing the simulated South Atlantic heat and salt transports based on virtual particle tracking methods, and then apply it to a representative ensemble of state-of-the-art climate models. I will elucidate the processes that determine the mean heat and salt transport in the South Atlantic and their changes under anthropogenic climate change, and how the heat and salt transport changes in the South Atlantic are linked to the strength of AMOC. The project results will improve future climate assessments and hence directly contribute to the ‘Adaptation to climate change’ mission of Horizon Europe. The training activities (e.g., in software development) and targeted career develo