RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A novel non-invasive and non-ionizing medical device for monitoring patients with implanted stents' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Susana Amorós is the CTO and co-founder of NIMBLE Diagnostics, a MedTech company developing a first in class microwave-based medical device for the continuos, non-invasive, non-ionizing monitoring of patients with implanted stents.Stents are one of the most implanted devices worldwide and are used to restore the correct flow of blood or other fluids. They are especially useful to prevent heart attacks or to treat their lasting symptoms, but once implanted can become blocked or damaged, which occur in 30% of the cases. The symptoms only appear after a stent is already 90% dysfunctional, which increases the incidenceof serious complications, including strokes, heart attacks or sudden death. The standard-of-care is still symptom-driven and is based on an invasive procedure called catheter angiography, involving anesthesia, X-ray exposure and 24h hospitalization recovery. This complex procedure is not standardized for recurrent monitoring, not allowing clinicians to act upon the problem until it has already manifested.The NIMBLE System can read the electromagnetic signature of the stent non-invasively, providing information on stent satus and malfunction that can be correlated with relevant clinical outcomes. Thus, NIMBLE enables early treatments to prevent negative outcomes and personalization of pharmacological therapy, shifting from reactive to proactive care. Our technology is currently at TRL5 with an MVP that has shown and excellent results in on-going validations. However, before we can offer our solution to cardiologists and primary care clinicians, we must complete key activities in our action plan.WomenTechEU will help us to better understand pricing and reimbursement strategies for the NIMBLE System in European markets, gain visibility with investors and collabor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Informational Frictions in Financial Markets', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

My research studies the impact of informational frictions on financial markets. In a frictionless market all economic agents have the same access to information. However, such homogeneity is often violated either because some agents have more information or they can better process it. A source of such informational advantage could be superior ability or financial skills. Naturally such skills are likely to be concentrated among institutional investors. But academic research shows that institutional investors do not generate better outcomes. My research argues that a subset of actively managed mutual fund managers can outperform passive benchmarks, and other investors, because they can choose better stocks or better time the changes in aggregate market conditions. These differences in investment skills have permanent effects on the ex-post performance of these investors. Identifying skilled investors undermines the postulates of efficient markets and provides useful tool for households to make efficient financial decisions. Another source of friction could be institutional differences fostering incentives to acquire and process information. For example I show that the degree of centralization or business concerns inside organizations affect incentives to acquire information and take excessive risk. Informational frictions can also result from the illegal acquisition of inside information. In my current work I want to understand the role of illegal insider trading for price formation and the overall quality of information in financial markets. On a broader level I study the implications of informational frictions for the growing income inequality between rich and poor. To explain why the inequality grows I show that some agents are endowed with more resources to access be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Algorithms and Lower Bounds: A Unified Approach' in the context of a Seventh Framework call.

assistant: **Objectives**

One of the fundamental goals of theoretical computer science is tounderstand the possibilities and limits of efficient computation. Thisquest has two dimensions. Thetheory of algorithms focuses on finding efficient solutions toproblems, while computational complexity theory aims to understand whenand why problems are hard to solve. These two areas have differentphilosophies and use different sets of techniques. However, in recentyears there have been indications of deep and mysterious connectionsbetween them.In this project, we propose to explore and develop the connections betweenalgorithmic analysis and complexity lower bounds in a systematic way.On the one hand, we plan to use complexity lower bound techniques as inspirationto design new and improved algorithms for Satisfiability and otherNP-complete problems, as well as to analyze existing algorithms better.On the other hand, we plan to strengthen implications yielding circuitlower bounds from non-trivial algorithms for Satisfiability, and to derivenew circuit lower bounds using these stronger implications.This project has potential for massive impact in both the areas of algorithmsand computational complexity. Improved algorithms for Satisfiability could leadto improved SAT solvers, and the new analytical tools would lead to a betterunderstanding of existing heuristics. Complexity lower bound questions arefundamentalbut notoriously difficult, and new lower bounds would open the way tounconditionally secure cryptographic protocols and derandomization ofprobabilistic algorithms. More broadly, this project aims to initiate greaterdialogue between the two areas, with an exchange of ideas and techniqueswhich leads to accelerated progress in both, as well as a deeper understandingof the nature of efficient computation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Population biology and molecular genetics of vectorial capacity in Anopheles gambiae: targeting reproductive behaviour and immunity for transmission-refractory interventions'.

assistant: **Objectives**

Malaria, one of the world’s most devastating diseases, is caused by protozoan parasites of the genus Plasmodium and is obligatory transmitted to humans by anopheline mosquitoes. The African mosquito species Anopheles gambiae s.s., is the major vector of this disease. Research groups from 3 European countries and 3 African teams will integrate their resources and scientific expertise in malaria research to expand knowledge of mosquito biology and of vector-parasite interactions, exploiting the opportunities provided by the recently available genome information and technological developments for mosquito vectors. The joint scientific program of the MALVECBLOK Consortium integrates for the first time three crucial aspects of biology of An. gambiae: reproduction, immunity and population biology, with the aim to ultimately provide novel concepts and targets for malaria control. The main objectives will address: (i) The molecular bases of reproductive biology of the mosquito vector, and its effects on immunity and Plasmodium transmission; (ii) The molecular mechanisms which determine the mosquito immune status and regulate Plasmodium sporogony and transmission, in both laboratory settings and natural populations; (iii) The role of genetic polymorphism in genes controlling reproduction and immunity on structure of mosquito populations and malaria transmission in Africa. In order to reach these objectives, MALVECBLOK will employ a number of concerted strategies in support of its 3-year agenda. Special attention will be given to cutting-edge training opportunities and sharing of resources, by implementing interactive programmes for the training and exchange of personnel at all levels, and by rationalising and coordinating investment. The innovative knowledge generated under this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Application of advanced modelling techniques to the numerical simulation of internal combustion engines' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the project is to develop a state of the art numerical simulation computer code to enable more accurate prediction of the processes found in an internal combustion engine. The work is aimed primarily at improving both the chemical modelling and fuel spray modelling as applied to diesel engines. Correct simulation of these processes is of great importance in the ability to predict the performance of an i.c. engine. Specifically a new auto-ignition model and advanced chemistry model will be developed using the reaction mechanism work being performed at Heidelberg. These sub-models will then be implemented in a current state of the art computational fluid dynamics code, under development at the Universitat Stuttgart. In parallel, a review and modification of the current fuel spray models will be made in order to introduce state of the art modelling techniques into this important facet of the simulation. Training content (objective, benefit and expected impact) The well renowned chemical modelling knowledge of Prof. Warnatz's group at the Universitat Heidelberg will enable me to learn about turbulent reactive flows which together with my knowledge of two-phase flow modelling will enable the development of techniques which can be applied to the large number of these flows which have multi-phase flows as an important part. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Teaming conductivity and chemical functionality in metal-organic frameworks for zinc‑ion batteries' in the context of a Horizon Europe call.

assistant: **Objectives**

Zinc-ion batteries (ZIBs) are among the most promising electrochemical energy storage (EES) technologies that could meet the future demand for green and safe storage of electric power, which is vital for a low carbon and fossil-fuel independent civilization. However, the low cost, Earth-abundance and superior safety/stability of zinc (Zn) in comparison to lithium-ion batteries, comes with formidable challenges, such as slow zinc ion migration and dendrite growth, limiting their charging/discharging time and life-span. Recent advances have expanded the design toolbox of metal organic frameworks (MOFs) and of tailored graphene derivatives – the core expertise of the applicant and of the host institution, respectively– which could drive the developments towards the next generation of ZIBs. The Z-ION project comes to meet the fundamental need for decarbonisation enabling safe, sustainable and low-cost batteries via the exploration of 3D and 2D conductive MOFs (CMOFs) and hybrids thereof with tailored graphene derivatives as hosts for Zn, which have so far remained largely unexplored in ZIBs. The conductivity and open framework of these materials, in comparison to the present insulating and low porosity cathodes, can boost Zn ion migration. Functionalization of both materials with chemical groups suitable for Zn coordination can streamline a homogeneous and dendrite-free deposition of metallic Zn at the anode through directed nucleation in their frameworks and at coordination sites. Importantly, tailored graphene derivatives with dense out-of-plane functionalities can facilitate the formation of covalent hybrids with CMOFs, ascribing hierarchical porosity and conductive bridges between the CMOF particles or sheets. The Z-ION project will thus offer indispensable knowledge fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Genes that control human DNA replication' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

We study the process of chromosome duplication, which ensures that a copy of the entire genome can be passed to each of the daughter cells during mitosis. The molecular mechanisms for the synthesis of new DNA chains are evolutionary conserved between prokaryotes and eukaryotes, but the regulation of chromosomal replication is more complex in the latter. A large group of genes have been identified that control DNA replication in yeast and metazoa. Most of them encode proteins known as initiators" that are responsible for selecting and activating the genomic regions that serve as "origins of replication". One of their presumed functions is the recruitment and assembly of DNA helicases and DNA polymerases to the chromatin.With this project we seek to characterize several human initiators, using a combination of genetic and biochemistry techniques. The function of genes such as ORC1 (encoding the large subunit of the origin recognition complex, ORC), CDC6 (encoding an ORC1-related gene), and MCM2-7 (six genes encoding the subunits of a potential DNA helicase) will be assessed in human cells by RNAi-mediated "loss of function" assays. The study will be extended to other initiators such as GINS, a protein complex identified in yeast that remains uncharacterised in mammalian cells. Besides the anticipated roles of these initiators in DNA replication, they may be involved in the cellular responses to different types of DNA damage. Interference with DNA replication increases the frequency of chromosome instability in model systems. Therefore, "replicational stress" in mammalian cells could be a driving force of tumorigenesis."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Neuromorphic Technology' to be submitted under Horizon 2020.

assistant: **Abstract**

Neuromorphic engineering is a ground-breaking approach to design of computing technology that draws inspiration from the powerful and efficient biological neural processing systems. Neuromorphic devices are able to carry out sensing, processing, and motor control strategies with ultra-low power performance. Today's neuromorphic community in Europe is leading the state of the art in this domain. The community counts an increasing number of labs that work on theory, modelling, and implementation of neuromorphic computing systems using both conventional VLSI technologies, emerging memristive devices,  photonics, spin-based, and other nano-technological solutions. To enable the uptake of this technology and to match the needs of real-world applications in future products that solve real-world tasks in industry, health-care, assistive systems, and consumer devices, a strong and sustainable communication channel between research labs and different stakeholders is needed. To achieve this goal, the NEUROTECH project aims to (1) create a comprehensive online platform that will integrate information about all involved parties, the state of the art,  and showcase latest technology advancement strengthening the NCT community and increasing its impact and visibility; (2) actively reach out to industry stakeholders to get them involved in shaping future research directions and to facilitate uptake of existing technology; (3)  promote public interest in NCT by show-casting key technologies; and (4) shape educational resources in this interdisciplinary field targeting students with different backgrounds. The CSA will be the connecting element that will allow us to consolidate and disseminate the state of the art of neuromorphic technology and to create a transforming roadmap for future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reconstruction Biology in Plant Sciences Doctoral Training Program', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The rePLANT (Reconstruction Biology in Plant Sciences) Doctoral Training Program is an ambitious research and training initiative coordinated by the Centre for Research in Agricultural Genomics (CRAG; Barcelona, Spain) together with the Max Planck Institute for Plant Breeding Research (MPIPZ; Cologne, Germany) and the John Innes Centre (JIC; Norwich, UK). rePLANT is designed to conduct, and train in, interdisciplinary and intersectoral collaborative research projects between the three participating institutions, with the additional collaboration and support of associated partner organisations (private companies, and research centres and academic institutions), both national and international.  The program will offer twenty (20) four-year doctoral fellowships and will be focused on: training in advanced research topics and technologies; training in non-research oriented transferable and transversal skills; collaborative research projects and secondments; and international networking in both the academic and the industrial sectors; all in order to enrich the training of the doctoral students and enhance their professional development while conducting projects of research excellence in the area of reconstruction biology in plant sciences. Reconstruction biology leverages current knowledge on plant traits and their underlying genes and molecules to understand trait diversification and innovation in a phylogenetic framework, i.e. within and between related species. rePLANT will conduct reconstruction biology at three levels of biological organisation: cell-free systems, whole organisms and ecosystems. With rePLANT, we expect to define quantitative trait models and uncover emergent properties, i.e. system features that the individual components do not have, as well as insight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Elucidating the crosstalk between the immune system and brown adipose tissue in humans', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Brown adipose tissue (BAT) is a promising therapeutic target to improve cardiometabolic health. However, BAT metabolism is dysfunctional in obesity. Hence, it is highly relevant to ascertain which mechanisms modulate BAT function and how it can be improved in this context.Mice studies indicate that the immune cells-brown adipocytes molecular interactions within BAT modulate its function. Indeed, mice knockout for the transcript Mecp2 in BAT macrophages show impaired BAT function and develop obesity. Further, cold acclimation activates specific subsets of infiltrated immune cells which improves BAT function. Altogether points to infiltrated immune cells as key players regulating BAT- but their identity and role, and if they can be targeted to activate BAT in humans, is unknown.The main questions we aim to tackle are: i) Which are the immune cell populations within human BAT? ii) Does local inflammation exist in BAT of obese subjects? Is it related to their disrupted BAT oxidative and metabolic capacity? iii) Is the BAT oxidative and metabolic capacity improvement, after a 3-month cold acclimation, driven by changes in BAT immune cell profile? To answer these questions, IMMUNOBAT will characterize the immune cell profile of BAT in lean and obese subjects, using novel single-cell omics in samples obtained by neck surgery. BAT oxidative and metabolic capacity will be assessed in vivo by state-of-art methods, combining the use of 15O-O2 and 15O-H2O - PET measures with in vitro mitochondrial respiration assays of brown adipocytes. These measures will be repeated in obese subjects after a 3-month cold acclimation (the most powerful stimulus to activate BAT).IMMUNOBAT will provide new mechanistic insights into obesity pathogenesis, at the same time that it expects to find new t