RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Snow Core Accumulation from Delta-15N Isotopes' (SCADI) targeting Horizon 2020.

assistant: **Abstract**

Future sea level rise threatens infrastructure worth trillions of euros and the livelihoods of millions of people. The magnitude and rapidity of this rise heavily relies on how the mass balance of the East Antarctic Ice Sheet (EAIS) responds to a warming climate, as a net loss of just 1% mass will increase sea level by ~0.7 m. However, any increased ice loss and resulting sea level rise may be partly offset if warming also increases snow accumulation on the EAIS. Currently, our understanding of exactly how EAIS accumulation rates respond to climate change is uncertain as modern records are sparse and the deuterium ratios used as an accumulation proxy in ice cores are affected by several other climate variables. This project aims to fully develop and apply an independent methodology to infer past snow accumulation rates using the fractionation of nitrogen isotopes in nitrate (NO3-). After NO3- is naturally deposited on the Antarctic snow surface, exposure to sunlight promotes photolytic loss of nitrate that favors 14NO3- over 15NO3-. As a result, the 15N/14N ratio (δ15N) of remaining NO3- steadily increases until enough snow accumulates to bury the NO3- below the photic zone and stop the process. Accumulation rate changes can thus extend or reduce the NO3-exposure time and degree of δ15N change. Through a suite of newly collected and archived snow/ice samples that cover a wide range of modern EAIS accumulation rates, the empirical relationship between δ15N and snow accumulation will be quantified and applied to 160 ka of data from the Vostok and EPICA Dome C ice cores. These new δ15N analyses will independently estimate how snow accumulation at the sites responded to the dramatic global climate changes of the past two glacial cycles, including two periods of rapid deglac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Defective Titanium Metal-Organic Frameworks' (DefTiMOFs), addressing dissemination and exploitation.

assistant: **Impact**

Metal-Organic Frameworks (MOFs) – porous materials with almost unlimited chemical and structural diversity - have incited an interesting alternative to the drawbacks that nanotechnology is currently facing. The defect engineering of MOFs has been used as a tool to modify their porosity, chemical reactivity and electronic conductivity among other properties, but research is still limited in the vast majority towards Zr-MOFs. Notably, defect chemistry of Ti-MOFs remains unexplored despite that the pristine materials photoactivity, chemical and structural stability and Titanium being an abundant biocompatible metal.This project, entitled `Defective Titanium Metal-Organic-Frameworks(DefTiMOFs)’ aims to develop novel high-throughput (HT)synthetic methodologies for the control of not only defect chemistry of Ti-MOFs,but also of their particle size and inner surface (porefunctionalisation) towards the controllable modification of their properties. HT synthesis will be convened with a set of novel characterisation techniques (mainly synchrotron-based) for atomic and molecular level of characterisation of defects, aiming to correlate synthetic conditions with defect formation (defect type, densityand spatial distribution within the framework)in order to provide thebase of knowledge to anticipate their properties based on the synthetic conditions. This will then allow for defect engineering of MOFs using a wide range of materials.In view of the above and inspired by the high demand for clean and renewable energy sources including efficient and affordablewater delivery systems in places with limited access to drinkablewater, the DefTiMOFs project aims to correlate defect chemistry of Ti-MOFs with their performance towards environmentally friendly applications. This will lead to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The European Polar Research Icebreaker Consortium AURORA BOREALIS' (ERICON-AB).

assistant: **Concept**

The ERICON-AB project will generate the strategic, legal, financial and organisational frameworks required from National Governments and the European Commission to commit financial resources to the construction and running of the European Polar Research Icebreaker AURORA BOREALIS. Scientific management frameworks will be assessed including mechanisms to handle dedicated large-scale multi-year or special mission specific research programmes. The strategic integration of the facility into the fabric of the European Research Area shall be achieved by connecting the national research priorities and the demand of ship time of the stakeholder countries with a European level facility. The relevance of the facility in promoting science and technology cooperation with EU strategic partner countries such as the Russian Federation will be specifically analysed. Deliverables will focus on moving the project from the preparatory phase to the construction phase by addressing key barriers especially in relation to engineering financial models that allow the mixed participation of EU member states and Non-EU partner countries. Consortium partners and legal experts will develop the legal/political frameworks for joint ownership and operation of a multi-country research facility. A dedicated legal implementation structure for managing and operating the AURORA BOREALIS will be proposed and its connection with other existing research assets such as Polar Stations, air support and supporting satellite assets will be analysed. The final deliverables of this project will be concerned with reaching a decision point and agreement with nations ready to move forward with the construction phase. It is anticipated that a series of natural decision points for agencies/governments to pass on their in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Search for Higgs boson pair production' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Within two years of the discovery of a Higgs boson with a mass near 125 GeV, a set of properties measurements have confirmed, within current experimental/theory uncertainties, its Standard Model (SM) nature. Nevertheless, beyond the SM theories offer a rich phenomenology and exciting prospects for the discovery of New Physics in the Higgs sector. This project aims to observe physics beyond the SM in   the Higgs boson sector through the search for Higgs boson, h pairs in the hh->γγb bbar channel, which benefits from the large h-> b bbar branching ratio, efficient diphoton trigger, low backgrounds and excellent diphoton invariant mass resolution.  Both the resonant and non-resonant production are considered. To this end, the proton-proton collision data collected by the ATLAS experiment at a centre-of-mass energy of 13 TeV at  the Large Hadron Collider over the next two years, will be used and are expected to amount to 70/fb. The proposal to search for anomalous Higgs boson production and for heavy resonant  states decaying to hh is original, and innovative methods in all aspects of the project will be employed. The results of the project, which will provide new information on the h self-couplings and the production of new resonances decaying to hh, will be interpreted within various theoretical frameworks, with emphasis in two Higgs-doublet models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dietary polyphenols, gut microbes and human health: A systems biology approach' in the context of a Sixth Framework call.

assistant: **Objectives**

The interactions between trillions of gut microbes (microbiota) and the human host represent a significant source of untapped knowledge that can be used to unravel the complexity of human health. This is also true for dietary compounds that could be used strategically by the food industry to prevent chronic disease. Polyphenols sit firmly in this domain and applying a systems biology approach offers a key opportunity to effectively use these compounds in consumer products. Polyphenol research has been hindered by a lack of knowledge of what occurs to them in the human gut, particularly how they are metabolised by the gut microbiota and their bioavailability.Three systems are involved in this: the consortium of polyphenols in the diet, the consortium of gut microbiota that metabolise them prior to absorption, and the human metabonome. A mechanistic understanding of the interaction between these complex systems will allow intervention by the food industry to generate novel functional foods with health benefits for the consumer. A systems biology approach will provide this and is precisely the objective of this proposal: To develop a systems biology approach to understand and predict the health effects of dietary xenobiotic compounds through host-microbiota interactions.A weight of evidence now supports the use of polyphenols for reducing the risk of developing cardiovascular disease and this is the initial target. Bio-availability remains the key issue that needs to be resolved prior to using these compounds as functional food ingredients. To achieve this objective requires the combined efforts of several scientific disciplines which are currently spread across independent organisations in the EU. Transferring this knowledge and working together to achieve this aim in a c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EURO-MILS:\nSecure European Virtualisation for Trustworthy Applications in Critical Domains' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cyber-physical networks based on embedded systems are part of our society and gain spread and importance. Next generations of aircrafts and cars will be tightly interconnected with each other, with the Internet and other infrastructures. The same holds for many industries and areas of our life. Ubiquitous, highly critical systems go online and create a domain of mixed criticalities, where security and safety requirements of different levels mix. Today, state of the art technology does not provide trustworthiness for such interconnection and mix.<br/>The project's cornerstone is MILS (Multiple Independent Levels of Security), a high-assurance security architecture that supports the coexistence of untrusted and trusted components, based on verifiable separation mechanisms and controlled information flow.For the first time in Europe, EURO-MILS does a complete Common Criteria" security evaluation of a MILS system to its highest levels of assurance, including formal verification engineering. Hardware dependencies are addressed from the beginning by prototype development on two hardware platforms in automotive and avionics.EURO-MILS is strongly market oriented, is carried out in pan-European context, and has an advisory board with government IT security authorities (BSI-Germany and ANSSI-France). In addition, the methodology gained from this high-assurance certification and investigating  MILS business, legal, and social acceptance benefit not only the MILS domain but all high-assurance security certifications in Europe.The project brings together eight leading industrial companies, a research company, two research oriented SMEs, and three universities from five European countries to form a complete chain stretching from basic research, via applied research, up to end-user or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rho GTPase cross-talk with syndecan-4 regulates pro-fibrotic mechanotransduction in the heart' (ROCKSOFT) targeting Horizon 2020.

assistant: **Abstract**

Cardiac fibrosis is a major cause of diastolic heart failure, a condition affecting millions of people worldwide. Treatment is currently lacking, reflecting a lack of understanding of cardiac fibroblast physiology, the main cell type responsible for extracellular matrix (ECM) production and development of fibrosis. Mechanical stress activates cardiac fibroblasts causing differentiation into myofibroblasts with excessive production of ECM. I previously showed that syndecan-4 (SDC4) is essential for myofibroblast differentiation in response to mechanical stress, although the exact mechanism was not fully elucidated. SDC4 regulates Rho GTPases and Ca2+ influx through TRPC7 channels, previously suggested to be stretch-activated. Thus, we hypothesize that SDC4-dependent Ca2+ signalling and Rho GTPase activation are crucial for translating mechanical stress into pro-fibrotic fibroblast activity. Despite having Ca2+ binding properties on the extracellular part, no studies have examined the role of SDC4 in regulating extracellular Ca2+ distribution and dynamics. Based on preliminary data, we here introduce the novel concept of extracellular Ca2+ microdomains that are created and maintained by SDC4. These microdomains are conceivably affected by changes in cell contraction and actin cytoskeleton organisation, thus promoting fibrotic remodelling of the heart in response to aberrant Rho GTPase signalling in the fibroblasts. To investigate these hypotheses in cardiac fibroblasts, I have developed a novel in vitro model that combines stiffness and stretch to induce myofibroblast differentiation, and study the process using state-of-the art CRISPR gene editing. The expertise of Prof. Cord Brakebusch in Rho GTPase function and CRISPR combined with my expertise in SDC4 mechanotransduct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Solutions for improving Agroecosystem and Crop Efficiency for water and nutrient use' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

SolACE's overarching goal is to help European agriculture facing the challenge to deal with more frequent combined limitations of water and nutrients in the coming decades, through the design of novel crop genotypes and agroecosystem management innovations to improve water and nutrient (i.e. N and P) use efficiency. To achieve this goal, SolACE will focus its activities on three major European crops - potato, bread and durum wheat - and will identify the (i) optimum combinations of above- and below-ground traits for improving resource use efficiency, (ii) best-performing genotypes under combined water and N or P stresses and (iii) novel practices that make better use of plant-plant and plant-microbe interactions to access water, N and P resources in conventional, organic and conservation agriculture. SolACE will implement a double interactive innovation loop, based on agroecosystem management and breeding strategies, and will imply the engagement of diverse end-users, across the production chain, from farmers and farm advisors to NGOs, SMEs and larger industries in the agri-business sector, through the SolACE consortium and a range of stakeholders' events. The tested innovations will include crop genotype mixtures, legume-based crop rotations and cover crops, microbial inoculants, as well as improved decision support systems and hybrids or products from genomic selection and participatory evolutionary breeding schemes. SolACE will implement complementary approaches, from data mining, modelling, phenotyping in high throughput platforms and field conditions, to experiments in research stations and farmers' networks in contrasted pedo-climatic zones. Through the co-design and co-assessment with the end-users of the selected novel breeding and management strategies to incre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dual Fuel Euro6 Engine Conversion Feasibility Study' (2014-2020) under Horizon 2020.

assistant: **Objectives**

G-Volution has been a pioneer of the use of dual fuel technology in heavy road haulage vehicles in the UK and Europe, with current operators using dual fuel on a daily basis reporting real world CO2 emissions reduction of at least 15%, with consequent reductions in NOx and particulate emissions.  The Company has invested heavily in development for more than 8 years, producing a range of patented technology.  The new Euro 6 solution has been developed from GV’s patented Euro 5 solution, itself installed on a significant number of vehicle fleets, and demonstrated as part of the  current  Innovate UK Low carbon truck and refuelling infrastructure trial.  Commercial developments over the last year or so have led to initial sales success through the acceptance of the technology as a solution that provides the qualities demanded for future transport WorldwideThe objective of the overall project is to develop the current prototype Euro 6 prototype vehicle to provide the first commercially available retrofit solution for Euro6 engines.  The strategic intent is to accelerate growth and increase penetration across Europe, USA and Asia by reducing the cost & increasing the reliability of the system while developing strategic partners in key European and World markets.This first part proposal intends to examine the feasibility and route to:Refine design for components and controls in line with OEM quality standards. Re-engineer ancilliary items to comply with  OEM acceptable safety and other standards.Set targets for cost reduction based on market sizes and expectations and operating cost savings.Investigate, and set up, a suitable professional supply chain to meet cost targets and quality.Investigate certification and homologation routes for various territories/continents.Produce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Innovative wet-sowing technology in the ecological agricultural and farming community'.

assistant: **Objectives**

The proposed project is focused on the farming & agricultural sector within which there are 135.000 farms concentrating on ecological agriculture and 20.700 SMEs in their supply chains. Ecological agriculture has today only reached 2,0% of the targeted 10% level of cultivated land during the next decade. They faces great challenges to increase competitiveness and meet customers demand, among those getting access to methods and equipment that increases efficiency, enables cost reduction and thus increases competitiveness.The global market for sowing and manuring/fertilizing machines is worth approximately 3.1 billion in 2002, and is growing at a constant 4,7% per year, but a substantial amount of all sowing and/or manuring/fertilizing machines is imported in to Europe from USA. In addition, the 135.000 EU ecological farmers faces increasing competition, demonstrated i.e. by the steady growth in import of seed and corn from low cost countries.Agriculture ranks among the most hazardous industries. Farmers are at high risk for fatal and nonfatal injuries, work-related lung diseases, noise-induced hearing loss, skin diseases, and certain cancers (brain, lip, and skin cancer). The total consumption of fertiliser in Central Europe is more than 5 Million ton and increasing and the total consumption of pesticides in UE-15 are more than 320 ton of active substance. Agriculture is the he main source for man made" Nitrogen Oxide (N2O) being a very potent greenhouse gas as well as having high ozone depletion potential.The farmers and the agricultural community and industry in Europe faces great challenges to meet the customers growing demand for ecological products and react to the increasing scepticism with regard to use of chemicals and genetic manipulated products in the agricult