RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PORE SPACE RECONSTRUCTION AND FLOW PROPERTY SIMULATION TOOL FOR CORE ANALYSIS' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The software to be validated in terms of economic and technical viability is an integrated computational tool for the simulation and characterisation of reservoir pore structure and the prediction of petrophysical and reservoir engineering properties. The project aims to offer a cost effective alternative to expensive laboratory testing by encompassing the following tasks :(i) BSE imaging and statistical analysis of the porous microstructure,(ii) 3-D stochastic simulation of the pore structure from its measured statistical properties,(iii) Geometrical and topological analysis of the 3-D simulated media (pore sizes, connectivity),(iv) Discrete modelling of single and two-phase flow properties (relative permeabilities, formation factor, resistivity index, capillary pressure curves),(v) Comparison of the predictions to measured data for European hydrocarbon bearing rocks.Existing chalk samples (provided by IFE) have been characterised (pore structure) and used for calibration, tuning, and benchmarking purposes. Thin sections were prepared and 2-D digitised images were produced for several samples. They have been used to obtain 3-D reconstructions of the pore space and subsequently predictions (based on numerical solution of local equations and on network approach) of macroscopic properties like permeability and formation factor. Work is continuing on real field samples (chalk and sandstone) to predict more properties (relative permeabilities, porosimetry curves, resistivity index) and compare with experimental measurements.The software package to be validated comprises an advanced computational tool for the simulation and characterisation of reservoir pore structure and the prediction of petrophysical and reservoir engineering properties. The software attempts to encompass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reseau thematique des centres europeens de recherche en sciences humaines sur l'ensemble euro-mediterraneen' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

There is an urgent need to gather , structure and strengthen our knowledge about the relations between Europe and the Mediterranean in its full complexity shaped by conflict and cooperation. In order to face that need we propose to create a thematic network linking different European social science research centres focusing on the Mediterranean area. Based on a survey of the state of the art " we propose to assess and improve existing research perspectives, to define a common knowledge base on topics of relevance to the Euro-Mediterranean area, and their implications for EU policies in this region. The programme addresses geopolitical dimensions and issues raised globalisation. In both respects the assumption is that the Mediterranean provides an adequate level of analysis for global developments."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Targeted Nanosystems for Improving Photodynamic Therapy and Diagnosis of Cancer' to be submitted under Seventh Framework.

assistant: **Abstract**

The overall objective of this proposal is the development of one or more nanosystems loaded with Foscan® and conjugated to cancer cell specific ligands for improving the efficacy and selectivity of photodynamic therapy (PDT) and optimise a fluorescence-based tumour imaging approach.  At present, PDT with Foscan® can be very effective but is not selective because Foscan® accumulates in the tumour tissue as well as in healthy ones. A great improvement of the therapy can only come from the availability of a carrier able to seek cancer cells and deliver Foscan® selectively to them. Three types of nanosystems, namely, liposomes, silica nanoparticles or poly(lactide-co-glycolide) copolymer nanoparticles, have been selected as potential nanocarriers for the selective delivery of Foscan®. The selection was mainly based on the different chemical nature of these systems, which can affect biocompatibility. During the first part of the project each type of nanosystem will be optimised through in vitro and in vivo tests and leader nanocarriers will be selected and conjugated to cancer cells specific ligands for increasing the selective delivery of Foscan®. The ligands we will use (folic acid, EGF, and antibodies) for targeting the nanosystems find their corresponding receptor over-expressed on the surface of cancer cells, therefore allowing a selective delivery of drugs in these cells. In vitro and in vivo investigations will be carried to demonstrate the validity of our approach and deliver, at project conclusion, a final product which can then be tested clinically. Because of the red fluorescence emitted by Foscan®, once it is selectively accumulated in cancer cells fluorescence based technique can be used for tumour imaging and diagnosis. Therefore we expect to develop a Foscan®
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Complex photon-phonon coupling' (COPPOLa), addressing dissemination and exploitation.

assistant: **Impact**

When humans design devices to perform a given functionality, we often prioritize ordered patterns and symmetry over anything else. Optomechanics is a clear example where precisely fabricated nanometer-scale devices are required to interface efficiently light with the mechanical vibrations of matter at the nanoscale. This coupling provides an extra degree of freedom to control the light-matter interaction. In state-of-the art optomechanical crystals, unavoidable fabrication imperfections impose severe performance limits increasing the energy dissipation and hampering their optical and mechanical performance.Disorder and randomness are ubiquitous in nature. Complex biological systems are clear examples where the functionality is not optimized through symmetry. In fact, disorder and complexity can also be exploited as a resource instead of being suffered as a nuisance. But, even when considered detrimental, understanding the role of fabrication imperfections is crucial to avoid its dramatic impact in state-of-the art structures.In this action, we propose to study the role of fabrication imperfections in state-of-the art optomechanical crystals by deliberately introducing disorder in one- and two-dimensional structures. Our aim is to analyze the role of disorder by quantifying the coupling strength between photons and phonons vs. the amount of disorder, something so far unexplored in optomechanics. Furthermore, we want to investigate if the mechanical action of light is enhanced deep in the Anderson localization regime, as it has been proposed theoretically very recently. Understanding and quantifying the effect of disorder is crucial to reduce its impact but we can also use it to our benefit. The cutting-edge research proposed here can offer innovative solutions to open is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Solar Hydrogen via Water Splitting in Advanced Monolithic Reactors for Future Solar Power plants.'.

assistant: **Objectives**

Building on the results of FP5 project HYDROSOL the present proposal concerns the technical realisation and evaluation of a directly solar heated process for two-step thermo-chemical water splitting using an innovative solar thermochemical reactor as the core of a volumetric receiver. The reactor is based on ceramic honeycombs incorporating active metal oxide redox pair systems. This method provides two major advantages: Hence no transportation/recycling of vast amounts of solid materials is needed and Hydrogen product separation is straightforward. As a central result of HYDROSOL, the feasibility of solar hydrogen production and the capability for multi-cycling of the thermo-chemical process developed was applied and proven. The results of the experimental and conceptual investigation show that a scale- up is possible and worthwhile and that the technology applied is a promising method for mass production of renewable hydrogen. Cost analyses indicate that technical improvements of the HYDROSOL process provide the potential to reduce by the production costs of hydrogen from 18 to 10-12 Eurocent/kWh (LHV) in the medium-term and by ongoing commercialisation to 6 Eurocent/kWh (LHV) in the long-term. In the present Proposal, a pilot reactor for solar thermo-chemical hydrogen production will be designed, constructed, installed and operated. The tasks of the Project include the enhancement of long-term stability of the thermochemical reactor, the development of operation/control strategy for continuous production of hydrogen, the design and development of a 100 kWth pilot reactor, the installation and test operation of the pilot reactor and all necessary peripheral components at a solar platform. Finally a detailed technical and economic evaluation of the entire process and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'PREcision MEDicine with induced pluripotent stem cells for Cardiac Arrhythmias Risk Evaluation'.

assistant: **Objectives**

Long QT Syndrome (LQTS) is a severe arrhythmogenic condition characterised by the prolongation of the QT interval on the electrocardiogram. It is caused by genetic factors (congenital) or drugs (acquired) and sudden cardiac death can be the first manifestations of the disease. Advancements in genetic screenings have revealed profound links between genotype and phenotype for LQTS, improving diagnosis, risk stratification and therapy; However, it is still poorly understood why patients with identical pathogenic mutations have different clinical phenotypes, which factors are involved in this unpredictable disease severity and how we can protect these subjects from drug treatments that are safe in the general population.We do need improved and more physiological in vitro models to simulate arrhythmias in vitro, effective for drug testing, to identify, evaluate and study factors that shape the arrhythmogenic risk in vulnerable subjects.Here I propose a precision medicine approach that uses human pluripotent stem cells-derived cardiomyocytes (hPSC-CMs) from LQTS families (rare resources that include male, female, symptomatic and asymptomatic patients) to: i) demonstrate that the hiPSC technology can reproduce in vitro the clinical disease severity observed in symptomatic vs asymptomatic LQTS mutation carriers; ii) create an in vitro interdisciplinary pharmacological approach with proarrhythmic drugs which combines matched electrophysiological, contractile, molecular and genetic assays; iii) identify and evaluate the factors affecting the arrhythmogenic risk in predisposed subjects.This pipeline to assess arrhythmia susceptibility from patient-specific hiPSC-CMs can be applicable to other arrhythmogenic syndromes. The results of this project will contribute to reduce the use o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Counting Atoms in nanomaterials' in the context of a Seventh Framework call.

assistant: **Objectives**

COUNTING ATOMS IN NANOMATERIALS Advanced electron microscopy for solid state materials has evolved from a qualitative imaging setup to a quantitative scientific technique. This will allow us not only to probe and better understand the fundamental behaviour of (nano) materials at an atomic level but also to guide technology towards new horizons. The installation in 2009 of a new and unique electron microscope with a real space resolution of 50 pm and an energy resolution of 100 meV will make it possible to perform unique experiments. We believe that the position of atoms at an interface or at a surface can be determined with a precision of 1 pm; this precision is essential as input for modelling the materials properties. It will be first applied to explain the fascinating behaviour of multilayer ceramic materials. The new experimental limits will also allow us to literally count the number of atoms within an atomic columns; particularly counting the number of foreign atoms. This will not only require experimental skills, but also theoretical support. A real challenge is probing the magnetic and electronic information of a single atom column. According to theory this would be possible using ultra high resolution. This new probing technique will be of extreme importance for e.g. spintronics. Modern (nano) technology more and more requires information in 3 dimensions (3D), rather than in 2D. This is possible through electron tomography; this technique will be optimised in order to obtain sub nanometer precision. A final challenge is the study of the interface between soft matter (bio- or organic materials) and hard matter. This was hitherto impossible because of the radiation damage of the electron beam. With the possibility to lower the voltage to 80 kV and possibly 50 kV,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'ASAMBA:AsteroSeismic Approach Towards Understanding Massive Blue SupergiAnts'.

assistant: **Innovation**

The recent space-born missions dedicated to studying stellar variabilityproviding unprecedented high-precision photometry of variable massiveAdditionally, we have also monitored a sample of oscillating blue supergiants in high-precision spectroscopy over 7 years.Such rich observational data call for carefully designed methods for astrophysical interpretation.This project aims to develop and provide such methodology.Our tools will be used to enhance the understanding of the physics of massive B-type dwarfs and BA-type supergiants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Extremely High-Speed Laser Processes For Sustainable And Flexible Manufacturing' (LaserWay) targeting Horizon Europe.

assistant: **Abstract**

Recent events such as the COVID pandemic and the Ukraine war have increased global uncertainty and prompted European companies to rethink their  global supply chain and production methods. Given the unpredictable nature of potential shocks, it is crucial for European industry to maintain a high degree of flexibility and adaptability in order to swiftly respond to sudden changes, whenever they may occur.The LaserWay project aims to revolutionize the manufacturing industry by replacing conventional, inefficient, and environmentally harmful methods with highly flexible production lines based on high-speed laser technology. Laser blanking, laser micro-drilling, and extreme high-speed laser material deposition (EHLA) are the three laser manufacturing technologies selected for their potential to create more sustainable manufacturing processes and products.The project focuses on developing WayFASTER machines to improve the performance of the laser technologies through lightweight designs, vibration control techniques, and program optimizations tailored for high-speed laser applications. WayFASTER Photonics aims to ensure precise delivery of the laser beam at extreme speeds, targeting three laser technologies with unique demands. The WaySTRONGER integration concept aims to enhance the sustainability, resilience, and flexibility of current manufacturing processes by integrating new technologies mechanically and digitally.The project's success will provide a competitive edge for industries, such as automotive and aerospace, by reducing processing times, improving material usage, and enhancing end-product quality. The advancements made through the LaserWay project will drive innovation in high-speed laser processing, solidifying Europe's position as a global leader in advanced man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Methodology, tools and architectures for electronic consistent knowledge management across projects and between enterprises in the construction domain' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This project aims at specifying and developing an open model-based infrastructure and a set of tools that promote consistent knowledge management within collaborative construction environments. The work will rely on a deep understanding of knowledge management activities of European construction companies. The analysis of the semantics within and across documents will lead onto the development of ontologies and adaptive mechanisms that can organise documents according to their contents and interdependencies. The web-based infrastructure will include services allowing the creation, capturing, indexing retrieval and dissemination of knowledge. It will also favour the integration of proprietary tools. The e-COGNOS approach will be tested and evaluated through a series of field trials. This will be followed by the delivery of business recommendations regarding the deployment of e-COGNOS in the construction sector.The project's outcome consists of 3 main e-COGNOS products:(1) the e-COGNOS Knowledge Management Infrastructure (e-CKMI),(2) the e-COGNOS Ontology Server (e-COSer), and(3) the e-COGNOS Ontology. Integrated pilots have been set-up, tested and evaluated in each of the four end-user organisations of the consortium.(1) The e-CKMI solution (full version) is available in one single package (including the e-COSer and ontology) as a GPL OpenSource Software. Essentially, the e-CKMI is a Web-based solution supported by a domain ontology. It operates as a middleware solution in which the concept of service plays the main role. Broadly speaking, the e-CKMI provides Web-services to support the major functionalities identified in the classical KM cycle, namely: acquisition, cleansing/transformation, indexing, updating, refreshing, searching/discovering, and sharing/dissemination
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Optimized esterase biocatalysts for cost-effective industrial production'.

assistant: **Innovation**

OPTIBIOCAT is a 48 months project aimed at developing biocatalysts based on feruloyl esterases (FAEs) and glucuronoyl esterases (GEs) for production of phenolic fatty- and sugar- esters with antioxidant activity for cosmetic industry, expanding the number/type of industrial biotransformations. Selected FAEs and GEs available within the consortium will be improved for their thermo- and solvent- resistance and substrate specificity by site-directed mutagenesis and directed evolution. Novel enzymes will be discovered by mining for new genes from available genomes. An inventory of novel FAEs and GEs will be developed including 50 fungal and 500 bacterial esterases, 25 site-directed and 20 directed evolved mutants. Enzymatic performances will be optimized to enhance the yield (up to the theoretical yield of 100%) and productivity (up to 0.5-1 g/l/h) of reactions giving the main targeted antioxidants: butyl ferulate, p-coumarate, caffeate, sinapate and 5-O-(trans-feruloyl)-arabinofuranose (using FAEs), glucuronate and benzyl glucuronate (using GEs). FAEs and GEs will be also tested for production of other compounds with improved biological activity and properties of hydrophilicity/hydrophobicity for cosmetic applications. Cost-effective methods will be developed for production of the new biocatalysts, in the g/L scale, and for their technical application to produce antioxidants for cosmetic industry, up to 20L. Enzyme immobilization will increase their recyclability up to ten cycles. The ability of the developed catalysts to work in conditions miming the industrial ones with reduced use of solvents and lower temperature than the chemical routes will be demonstrated. The techno-economic viability and environmental friendliness will be assessed considering a full industrial sca