RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Spin polarised electron spectroscopy of nanodevices and interface magnetism'.

assistant: **Concept**

Electron polarisation analysis of magnetic films in UHV allows the surface magnetisation, interface polarisation and spin transmission through over layers to be probed in site. The interface magnetism will be investigated in ultra thin films, and spin valve structures using a micro-Mott spin detector in an MBE growth chambers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Programmable Atomic Large-Scale Quantum Simulation'.

assistant: **Innovation**

PASQuanS will perform a decisive transformative step for quantum simulation towards programmable analogue simulators addressing questions in fundamental science, materials development, quantum chemistry and real-world problems of high importance in industry. PASQuanS builds on the impressive achievements of the most advanced quantum simulation platforms, based on atoms and ions. The neutral-atom simulators handle more than 50 cold atoms in optical lattices or arrays of optical tweezers, interacting via either collisional or Rydberg-state-mediated interactions. The ion-trap platform reaches unsurpassed control with up to 20 ions. By scaling up these platforms towards >1000 atoms/ions, by improving control methods and making these simulators fully programmable, PASQuanS will push these already well-advanced platforms far beyond both the state-of-the-art and the reach of classical computation. Full programmability will make it possible to address quantum annealing or optimization problems much sooner than digital quantum computation. PASQuanS will demonstrate a quantum advantage for non-trivial problems, paving the way towards practical and industrial applications. PASQuanS tightly unites five experimental groups with complementary methods to achieve the technological goals, connected with six theoretical teams focusing on certification, control techniques and applications of the programmable platforms, and five industrial partners in charge of the key developments of enabling technologies and possible commercial spin-offs of the project. PASQuanS will result in modular building blocks for a future generation of quantum simulators. Possible end-users of these simulators, major industrial actors, are tightly associated with the consortium. In a cross-fertilization process,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Energy-efficient membranes for carbon capture by crystal engineering of two-dimensional nanoporous materials' (UltimateMembranes) under Horizon 2020.

assistant: **Objectives**

The EU integrated strategic energy technology plan, SET-plan, in its 2016 progress report, has called for urgent measures on the carbon capture, however, the high energy-penalty and environmental issues related to the conventional capture process (amine-based scrubbing) has been a major bottleneck. High-performance membranes can reduce the energy penalty for the capture, are environment-friendly (no chemical is used, no waste is generated), can intensify chemical processes, and can be employed for the capture in a decentralized fashion. However, a technological breakthrough is needed to realize such chemically and thermally stable, high-performance membranes. This project seeks to develop the ultimate high-performance membranes for H2/CO2 (pre-combustion capture), CO2/N2 (post-combustion capture), and CO2/CH4 separations (natural gas sweetening). Based on calculations, these membranes will yield a gigantic gas permeance (1 and 0.1 million GPU for the H2 and the CO2 selective membranes, respectively), 1000 and 10-fold higher than that of the state-of-the-art polymeric and nanoporous membranes, respectively, reducing capital expenditure per unit performance and the needed membrane area. For this, we introduce three novel concepts, combining the top-down and the bottom-up crystal engineering approaches to develop size-selective, chemically and thermally stable, nanoporous two-dimensional membranes. First, exfoliated nanoporous 2d nanosheets will be stitched in-plane to synthesize the truly-2d membranes. Second, metal-organic frameworks will be confined across a nanoporous 2d matrix to prepare a composite 2d membrane. Third, atom-thick graphene films with tunable, uniform and size-selective nanopores will be crystallized using a novel thermodynamic equilibrium between the l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Controlling Biogenic Amines in Traditional Food Fermentations in Regional Europe' (BIAMFOOD).

assistant: **Innovation**

Food fermentations are among the traditional industries that have a long standing history worldwide. In spite of great technological advantages, much of the industry is still based on traditional, experienced-based techniques that are strongly rooted in specific geographic regions. In food fermentations, consortia of microorganisms are essential to the process, and determine the characteristics of the end products. They also are responsible for the production of biogenic amines (BA) that may cause serious human health problems following ingestion of fermented foods containing high concentrations of these compounds. This project focuses on the microorganisms in the food chain that produce biogenic amines with the main goal to improve the quality of traditional fermented food products by reducing/eliminating their biogenic amine content. Control of biogenic amines in the food products will significantly reduce the health risk for the consumer and, thereby, increase the competitiveness of the local industries. The challenge for the food industry is to produce food and beverages in which the levels of BA are minimized. The project focuses on three different fermentation processes in four different region of Europe. The project has both an analytical component aiming at identifying BA producers in the food chain and the conditions that result in BA production, as well as a controlling component aiming at a significant reduction or even elimination of BA in the food products. This will be achieved by formulating best practice guides, development of tools, and the utilization of new starter LAB. The whole food chain is considered. At the beginning of the food chain, the potential of microorganisms to form BA is analyzed; during the fermentation process the physiological condit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterization and control of thick composite structures' (1994-1998).

assistant: **Innovation**

The proposed areas of investigation for the network can be split into two principal areas of investigation, concerning thick glass fibre fabrics reinforced resin. First, mechanical characterization of both panels and tubes. Mechanical testing of thick samples cut from flat panels should enable measurement of both rigidities and strengths. For tubes, internal or external pressure testing is very expensive ; one way to avoid such heavy testing would be to perform simpler tests on rings cut from the tubes. However, technical difficulties, such as the high loads required to reach failure, together with theoretical problems linked to the use of more advanced plate theories taking transverse shear into account, hinder the development of reliable test methods. The total lack of standards in the area confirms that work is needed. Secondly, quality control of manufactured or in-situ components. Indeed, there is a need for damage assessment in existing structures that methods developed for the aeronautic industries cannot cope with. Ultrasonic scanning, for instance, will require much more energetic waves to investigate deeper in the material. Concurrently, simple quality control techniques are needed for both panels and tubes for small companies to check manufacturing processes. Modal analysis is a possible answer, but here again, important thicknesses or tubular shape are the key issues to be addressed. The first task to be performed by the network is to prepare concise reports to review the state of the art and the existing or potential needs of the lndustry.These reports will serve as work documents to establish the final network proposition. The second task also to be performed in this exploratory phase is to look for potential industrial or university partners to develop th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'HerQuLes: Chromatin Dynamics During Cellular Quiescence' under Horizon Europe.

assistant: **Concept**

Stem cell pools in our body regulate tissue differentiation in development and remain available during our lifetime for tissue regeneration. These cells exsit in a cell cycle arrested but metabolically active state known as quiescence. Understanding how these cells maintain quiescence and survive over years is fundamental, as its dysregulation impairs regenerative capacity and is linked to ageing, cancer, and degenerative diseases.The HerQuLes project aims to uncover the mechanisms by which key transcription factors establish and maintain cellular quiescence by studying a novel aspect: the chromatin organization during this state. Preliminary data strongly suggest that two transcription factors involved in the stress response play a pivotal role in modulating chromatin compaction during quiescence. However, the mechanisms by which the cell cycle is blocked remains an open question. To address this, I will use the nematode Caenorhabditis elegans, an excellent model for studying quiescence. Upon starvation, larvae enter in L1 arrest state that resembles mammalian stem cell quiescence. As in mammals, chromatin reorganization and stress-related transcriptional responses occur in arrested L1 larvae.Using cutting-edge in vivo tools, I will quantify the degree of chromatin compaction, determine which chromatin regions are bound by the transcription factors and study its physical interaction, all under L1 arrest. Quiescent cells accumulate damage over time, delaying re-entry into the cell cycle and contributing to age-related regenerative decline. European healthcare systems are challenged as the population over 65 is expected to double within the next 35 years, and so do the illnesses associated to ageing. HerQuLes provides mechanistic insights into how quiescence is preserved
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Emerging indUstries new value chains boosted by small Flying Objects' to be submitted under Horizon 2020.

assistant: **Abstract**

The UFO project is based on two main assumptions. First, business opportunities lie in the combination of space data with digital technologies and other sources of data. Embedded Key Enabling Technologies (KETs) into small flying objects (SFOs - drones, small satellites, high altitude platforms) represent a great opportunity to collect additional aerospace data, especially to drive the Artificial Intelligence revolution for various global applications. Second, the value added applications in Europe are mostly driven by SMEs. Thus, the UFO project aims at fostering the development of cross-sectoral industrial value chains between 6 emerging industries (Mobility technologies, Environmental, Blue Growth, Digital, Experience and Cultural and Creative industries), SFOs, embedded KETs and data analysis and exploitation solutions stimulating the development of new products and services by SMEs. To achieve this, the consortium provides a systemic and strategic vision. Clusters, which gather SMEs, large groups, R&D actors, and other innovation entities, are crucial to create links between different value chains, basically the data providers and the information product providers that turn raw data into valuable information. The UFO consortium and associate partner consisting of 8 emerging industry clusters including 5 SFOs, embedded KETs, ICT clusters, representing more than 1000 SMEs throughout 6 different EU countries and sectors. The partners have the capacity to carry such actions as they will foster partnerships between the different links (their members) of value chains and provide them incentives through the launch of call for proposals providing Financial Support to Third Parties (FSTP) and innovation services provided by clusters. They represent some of Europe’s most dyn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A PRivacy-prOTecting Environment for Child Transplants health-related and genomic data integration in the European Reference Network' (PROTECT-CHILD).

assistant: **Concept**

PROTECT-CHILD is a project that aims to improve the outcomes of rare pediatric transplant patients by integrating multiple sources of high-throughput data from registries, hospital-based and public repositories, complying with ongoing initiatives such as the European Open Science Cloud (EOSC) and the European Health Data Space (EHDS). The project focuses on the co-design of a secure and privacy-preserving infrastructure, harmonization of data standards, and creation of a public/private infrastructure for assembling large datasets to improve clinical outcomes. The project involves top-level expertise from a consortium of technology specialists, data standardization experts, and High-Performance Computing (HPC) centers, as well as clinical experts, legal experts, patients’ representatives, and policy makers. The project is aligned with EHDS and General Data Protection Regulation (GDPR) principles and aims to empower secure and compliant processing, analysis, and sharing of sensitive personal data, including genomics, while preserving data privacy and security.


**Keywords:** pediatric transplantation, data integration, data governance, data privacy, metadata, multi-platform, multi-scale, multi-source, machine learning, predictive modeling, clinical decision-making
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multimodal Regulation of Cullin-RING Ligases by CSN' in the context of a Seventh Framework call.

assistant: **Objectives**

The COP9 Signalosome (CSN) is an eight-subunit molecular machine conserved in eukaryotes. Defects in CSN function are reported in human disorders and a CSN-related pathway recently emerged as a promising cancer drug target. CSN regulates embryonic development, DNA repair, cell cycle checkpoint progression and autophagy. The remarkable pleiotropy of CSN is partially explained through its enzymatic activity towards Cullin-RING E3 ubiquitin ligases (CRLs), which are activated by neddylation and inactivated by CSN-mediated deneddylation. However, loss of CSN function results in loss of CRL activity in cells: an observation which has not been fully explained and is known as the 'CSN paradox'. Intriguingly, we recently observed stable CSN-CRL complexes, irrespective of CRL neddylation and our preliminary results suggest a novel model of multimodal regulation of CRL architecture and function by CSN.Our key research objectives are to structurally characterize CSN-CRL complexes, to determine their functional significance and to dissect the mechanisms, which regulate the interaction. Owing to our team’s complementary expertise and the already established molecular tools, we are in a unique position to achieve these experimentally challenging aims. Our hypotheses are guided by 3D structural data and will be validated in established in vitro assays. All required protein complexes can be purified in large amounts from recombinant systems. In parallel, testing specific predictions and activities in vivo will benefit from already available human cell lines. Our findings will be complemented by an unbiased, large-scale proteomic analysis to characterize distinct CRL-CSN complexes and identify relevant post-translational modifications that regulate complex formation.We expect our result
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Aligning pigmentation and repair: a holistic approach for UV protection dynamics' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The human body takes different measures in order to protect itself against the results of UV exposure and its accompanied hazards, such as skin cancer. Despite extensive studies regarding the molecular regulation of the two main UV protection mechanisms, namely, the DNA repair system and the pigmentation system, a comprehensive theory that simultaneously accounts for the two systems is still missing. Hence, the ground-breaking goal of this proposal is to elucidate, for the first time, the dynamic control used to schedule and synchronize the UV protection subsystems. Since these two systems serve the same physiological purpose, but on different time scales (DNA repair takes minutes, while pigmentation lasts hours to days), I propose to take the novel approach of focusing on their timing as an opportunity to uncover their regulation. As a first step, we exposed human and mouse skin to UV and found that UV exposure at 48hr intervals resulted in higher skin pigmentation than did exposure at 24hr intervals, even after controlling for total UV dosage. Furthermore, we found that the expression level of the melanocyte central regulator, MITF, exhibits damped oscillatory behaviour during this 48hr interval. I therefore hypothesize that the dynamic behaviour of the central regulator dictates the UV–response timing of the two protection systems. In the proposed research, I will take a holistic approach and address this issue from three complementary perspectives: (1) transcriptional dynamics, (2) temporal effects on cellular output, and (3) DNA repair after UV. This will be achieved by utilizing and developing new experimental and analytical tools that will allow us to correlate the temporal behaviours of a wide set of molecular markers. Reaching our goals will provide a breakthro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeted small-molecule Stabilisation of Protein-Protein Interactions' (TASPPI).

assistant: **Innovation**

The goal of the TASPPI European Training Network (ETN) is the establishment of a highly interdisciplinary research and educational training platform for early stage scientists in the Chemical Life Sciences to overcome the inherent boundaries between academia and industry and to increase their employability in both areas. To this end we have teamed up in a consortium comprising 5 partners from industry (AstraZeneca, GlaxoSmithKline, UCB, Lead Disocvery Center, Taros Chemicals) and 6 partners from academia (Universities of Dundee, Eindhoven, Leeds, Lille, Prague, and Siena). The scientific objective of the multi-sectorial Training Network is the development and implementation of a multidisciplinary technology platform bringing together structural molecular biology, chemical biology, cell biology, synthetic chemistry, and medicinal chemistry for the identification of Small-molecule Stabilizers of Protein-Protein Interactions (PPIs) as a novel class of therapeutic agents and basic research tool compounds. With this new technological approach we aim to address a number of unmet medical needs in the areas Cancer, Neurodegenerative Diseases (Alzheimer’s, Parkinson’s), Pulmonary Diseases, Inflammation and Metabolic Diseases (Diabetes).