RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Unravelling neuronal heterogeneity in energy homeostasis regulation'.

assistant: **Objectives**

This MSCA Reintegration proposal is aimed to study the heterogeneity of neuronal populations implicated in the maintenance of energy balance. Because of their location, neurons in the arcuate nucleus of the hypothalamus (ARC) integrate nutrient and hormonal signals carried in the blood. Then, they regulate downstream neuron’s activity in order to adapt food intake and energy expenditure. Deregulation of energy homeostasis can lead to obesity and diabetes, two of the major chronic diseases in the EU. AgRP neurons, an ARC population, have a prominent role in the regulation of food intake and systemic insulin sensitivity. They establish axonal projections with several brain areas and recent evidences show that each sub-circuit can have a specific function in the regulation of food intake and/or glucose homeostasis. For this fellowship I propose to use an innovative experimental approach to investigate a specific novel AgRP neuronal subpopulation, characterized by the expression of the UDP-receptor, P2Y6, as a first step to unravel the heterogeneity of the total population. Although P2Y6 activation increases short-term food intake, its effects on glucose homeostasis are still unknown. I plan to combine new recombinase technologies with state of the art techniques to genetically identify the AgRP, P2Y6 subpopulation and then: 1) characterize their in vivo dynamic response to physiological activators; 2) map specific AgRP+, P2Y6+ sub-circuits and dissect their role in each facet of energy homeostasis; and 3) investigate new molecular markers, as possible drugable targets. Results from this project will unveil new aspects of neuronal heterogeneity that participate in the regulation of energy homeostasis and will contribute to design new strategies to curb the actual obesity tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Scalable And Flexible optical Architecture for Reconfigurable Infrastructure' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Highly scalable & flexible optical transport networks are urgently required in order to meet the demands for unrelenting exponential data traffic growth (estimated at 40 - 50 % per annum). The number and diversity of bandwidth intensive applications and services is rapidly increasing, leading to new demands on transport networks. The present optical transport networks based on conventional fibres, however, are facing fundamental limits in capacity/throughput and are lacking in terms of network flexibility and control. The Scalable And Flexible optical Architecture for Reconfigurable Infrastructure (SAFARI) project aims at developing programmable optical hardware, and Space-Division Multiplexing (SDM)-based optical component technologies capable of realising highly scalable & flexible optical transport networks for the long term future. The high level objectives of the SAFARI project are to:- Develop programmable optical hardware allowing novel multi-flow transport functions which is scalable to at least 400 Gbps/channel transport, and implement the critical interworking capability required between the software-defined network (SDN) layer and the physical layer.- Develop SDM-based optical transport technology based on super-dense, high-count multicore fibres (MCFs) and multicore erbium-doped optical fibre amplifiers (MC-EDFAs). The technology should be capable of supporting more than 30 cores per-fibre.- Undertake system experiments on scalable & flexible optical transport networks based on the newly developed SDN-controlled interworking capability and capacity-scalable hardware, showcasing the unique functionality and capabilities made possible. Specific attention will be focussed on demonstrating that the SDN-controlled programmability developed is compatible with both
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Lactase persistence and the Cultural History of Europe'.

assistant: **Concept**

The ideal training for future researchers in Europe, draws together leading groups in the world, state-of-the-art methods and a clearly focused, important and emotive questions with widespread repercussions, and integrates them using sophisticated tools and training devices; welcome to LeCHE. This large (14 researcher, 24 participant) training network explores the origin and impact of dairying Europe. The ITN will draw on the latest genetic studies of modern humans and domestic animals to identify markers of specific traits, but will also travel back in time and search for these in ancient remains. The Lactase Persistence trait is under extreme selection in humans; ancient DNA analyses suggesting that it was absent in the first Neolithic farmers. Modern phylogeographic patterning indicates a high degree of co-evolution of humans and domesticates. We will test these hypotheses by using sophisticated chemical and isotopic geochemical analyses of artefacts and bones, combined with traditional archaeology to obtain direct evidence of milk consumption and explore husbandry practices.  All these data will be integrated into a large database.  Mathematical modelling of gene flow and selection in Neolithic populations, constrained by archaeological data, will be compared with modern distribution of genetic diversity and ancient remains.  Each student will have their own research project, but will be encouraged to think and work as a team, by network activities, including a sophisticated set of Web 2.0 tools for communication, summer schools and their co-authorship of a book, the latter to teach them writing, editing and team-working skills. The students will benefit from industrial involvement, both instrument/analytical, but also the involvement of the modern diary industry. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Beta amyloid oligomers in the early diagnosis of AD and as marker for treatment response' (EDAR) under Sixth Framework.

assistant: **Objectives**

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which currently affects 4 million subjects in the European Union. The prevalence of AD is expected to increase substantially the next decades due to the aging population. AD severely affects the quality of life of patients and their relatives. It also poses a major burden to the health care system. Abnormalities in beta amyloid processing are a key feature of the disease. Therapeutic strategies, which modify beta amyloid processing, are currently under development. The development of these drugs, however, is hampered by the lack of accurate diagnostic criteria for AD in the early stage and the lack of potential markers of treatment response. Recent studies indicated that beta amyloid oligomers play an important role in the early pathophysiology of AD. The aim of the present project is to investigate whether beta amyloid oligomers in cerebrospinal fluid, plasma, and serum can be used for the early diagnosis of AD and whether they can be used as a marker of treatment response. In it will be investigated whether genes known to be involved in beta amyloid processing influence levels of these markers.Oligomers will be measured using two techniques. The first is based on ultrasensitive immuno-polymerase chain reaction and will be developed during the project. The second is based on a combination of immunoprecipitation and ELISA and has already been developed by one of the partners. Measurements will be performed in cerebrospinal fluid, serum, and plasma samples of 100 subjects with AD, 250 subjects with mild cognitive impairment (a prodromal stage of AD), 100 subjects with other types of dementia, and 50 control subjects. In order to investigate the potential of beta amyloid oligomers to be used a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'REDD Fast Logging Assessment & Monitoring Environment' (REDD-FLAME).

assistant: **Innovation**

The REDD Fast Logging Assessment & Monitoring Environment (REDD-FLAME) project will design, prototype and demonstrate a system capable of monitoring tropical and sub-tropical forests using high-resolution radar (and optical) imagery acquired by Earth Observation satellites. By focussing on early detection of logging activities, the system will provide the means to quickly identify the first signs of deforestation and thus act as a tool to control resource use and sustainable development within these fragile and valuable environments. The system will form a high-resolution add-on for existing (semi-)operational low- to mid-resolution systems, providing hot-spot monitoring for areas at highest risk of deforestation. As such, it could be integrated into national or regional forest monitoring centres and provide inputs for large scale carbon emission assessments in the context of the UN-REDD (Reducing Emissions from Deforestation and Forest Degradation) Programme.The system will be developed in collaboration with investigators from developing countries on three continents in an effort to build lasting partnerships and transfer European expertise. Sites in Indonesia, Brazil and Mozambique have been chosen to represent a variety of forest types and deforestation issues, and thus to test the system’s versatility.The REDD-FLAME project will bring benefits to a wide range of parties concerned with deforestation in tropical and sub-tropical environments and build capacity in the host countries for managing forest resources and carbon balances. By implementing a dedicated version of REDD-FLAME for each participating ICP country, results targeted at their specific monitoring requirements, based on the strategies and policies for deforestation in place, will be provided to give time
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Silicate and baltic sea ecosystem response' to be submitted under Fifth Framework.

assistant: **Abstract**

Regulation of rivers and eutrophication in river basins has largely reduced dissolved silicate (DSi) loads to the Baltic Sea, which is partly responsible for decreasing DSi stocks reported. Reductions in DSi stocks can also be influenced by enhanced deposition in Baltic sediments due to marine eutrophicaton. There are indications that the proportion of diatoms has decreased while flagellates have increased in the Baltic. Similar species shift as a consequence of reduced DSi loads due to damming and marine europhication with far reaching effects for coastal ecosystems are reported worldwide. This project aims to quantify the relative importance of reduced loads vs. marine eutrophicaton for decreasing DSi stocks and its possible ecological effects on phytoplankton assemblages. The proposed project is focussed on the Baltic Sea, where the DSi problem is easier to discern, but the results have general relevance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MARA-BASED INDUSTRIAL LOW-COST IDENTIFICATION ASSAYS' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The fast and cost-efficient detection of pathogens is highly important in many sectors such as healthcare, agriculture, and food industry. However, current technologies are limited, and significant advances are required to develop low-cost (<10€) detection assays that can detect a few bacterial cells (<10 cells/ml) within less than one hour. In the FET-Open project MARA, which is the basis for MARILIA, we have developed novel technologies and tools that have a high exploitation potential. Thus, we have initiated the follow-up project MARILIA, which aims to exploit these results and realise a new detection concept for the fast, low-cost identification of human pathogens in water samples. In MARILIA, we will increase the technology readiness level (TRL) of our novel detection concept from TRL 2 to TRL 5. A well-balanced consortium has been established, comprising an applied research institute as coordinator (AIT, coordinated also the MARA project), a university (UZ), a basic research institute (RBI), an SME (D1, acting as business incubator) and a large company (IREN, representing a potential future customer). If the MARILIA detection assay meets the requirements defined by IREN, a start-up will be founded to commercially exploit the innovations in the post-project phase.


**Keywords:** Pathogen detection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transformation of neighbourhoods in a child-friendly way to increase the quality of life for all citizens.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Metamorphosis is on transforming neighbourhoods with a focus on children.Metamorphosis starts from the premise that when a neighbourhood has many children on its public spaces, this is a major indicator that it is well designed as a sustainable neighbourhood. The word sustainability itself is already inseparably combined with children as it implicates “designed for the next generations”. Thus Metamorphosis will address the challenges of the topic 4.5. from this perspective and will thus: 1. Transform car-oriented neighbourhoods into children-friendly neighbourhoods achieving behavioural change and increase in the quality of life2. Build the vision needed for such transformations3. Answer basic research questions related to neighbourhood transformation4. Achieve creative breakthrough innovations – in development, in design, in governance and in planning procedures – for  public spaces in neighbourhoods and urban districts5. Through the above described mechanisms, develop and implement children friendly mobility solutions 6. Evaluate take-up, involvement, process and impacts using innovative evaluation methodologies7. Develop and implement innovative transfer instruments to transfer Metamorphosis-innovations from city to city and country to country, also beyond the duration of the projectChildren can help to develop positive emotions for the neighbourhood (and this is a key issue, as behaviour and decisions are mostly determined by emotions, and only to a much lesser degree by rational arguments such as cost-benefit). Thus:- children can easily find a direct way to their parent’s hearts- to be against children’s needs and demands isn’t socially well acceptedMetamorphosis will include trial implementation cities with completely different neighbourhoods. Each city will part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rethinking Eastern European Cinema in a Post-Cold War Ideological Framework' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

EASTFILM aims to rethink the cinema of Eastern Europe in a revised theoretical framework and promote the values of this cinema locally and internationally. The project seeks to achieve its goal by focusing on three objectives: 1. The publication of a scholarly book on Eastern European cinema with a prestigious international press. 2. The incorporation of courses in Eastern European film into UVT’s curriculum. 3. The establishment of an Eastern European Film and Media Center within UVT. 1. Book Project: Orphans of the East Orphans of the East: Cinema and the Production of Eastern Europe’s Revolutionary Subject" is envisioned as an attempt to recuperate the values of Eastern European film and political culture for an English-language readership. It is a scholarly project in film and intellectual history, aiming to rethink the politics of this region’s cinema in a post-Cold War theoretical context. 2. I plan to introduce three classes in Eastern European cinema into three of UVT’s programs: the Masters Program in Regional Journalism, the Bachelor Program in Cultural Studies, and the Bachelor Program in International Relations. The classes will focus on various periods/regions/topics in Eastern European film. 3. The Eastern European Film and Media Center is envisioned as a collection of relevant fiction and documentary films, and film-studies literature from or about Eastern Europe. It will function as a local reference center for students and scholars interested in Eastern European cinema and culture. Relevance Besides contributing to the rethinking of Eastern European cinema on a regional and international level, the fulfillment of this project will help me establish myself as a film-studies scholar and enrich my host university’s curriculum. The Film and Media Center wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Genomic Targets and Function of Topoisomerase II isoforms during Stem Cell Differentiation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Topoisomerases are enzymes that solve topological problems arising from DNA templated processes such as replication, transcription, recombination and chromatin remodeling. The type II subfamily of Topoisomerases achieve this task by passing a region of duplex from the same or a different molecule through a double-stranded gap generated in DNA. Mammalian cells encode two isoforms of type II enzymes, Topoisomerase II alpha and beta, which have almost identical enzymatic properties in vitro. However, they show very different expression patterns and it is not known whether they differ in their distribution and action sites on the genome and in gene regulatory potential.We find that a switch in the expression from Topo II alpha to beta occurs during neuronal differentiation in vitro and in vivo. We propose to define the chromatin crosstalk of the two Topo II isoforms, alpha and beta, and its contribution to the transcriptome of embryonic stem cells and differentiated neurons respectively. We will combine our sophisticated in vitro mouse differentiation system with genome-wide identification of Topo II alpha binding sites in stem cells. These target sequences will be analyzed for any specific features using computational biology tools and related to the existing datasets of various epigenetic modifications and transcription (Tiwari et al. 2011, Nature Genetics). Using Topo II-specific inhibitors, we will identify Topo II alpha target genes that rely on its catalytic activity for their transcription state. We will next compare the Topo II alpha binding data from stem cells to our recently derived genomewide datasets of Topo II beta binding from neurons. Together, we aim to achieve an understanding of the target preference for the two Topo II isoforms, alpha and beta, with resp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'COMMONDEMO@IBC2003'.

assistant: **Concept**

This support activity concerns the organisation of a joint exhibition of IST funded projects at the IBC2003. The objective is to organise, design, build and operate an exhibition space in which 6 projects can demonstrate their achievements in the domain of networked AV services and home platforms. Several projects in the D2 1ST cluster Interfaces and Enhanced Services and Signal Processing and Mixed Reality, especially the projects ICE-CREAM, SHARE-it, SPATION, MOSES, MUFFINS and FUTURE HOME are working on the future platforms for interactive audio visual services. These projects contribute to the further development and evaluation of open standards in the broadcast and Internet domain. Delivery platforms based on open standards for the production, delivery and consumption of multimedia content are core to these projects. They all address a part of the end-to-end delivery chain.In addition, business models and evolving business roles are addressed for the different key actors of the end-to-end chain. These projects are planning to present their achievements on the IBC2003, which will be held at the AMSTERDAM RAI International Exhibition and Congress Centre, the Netherlands, from 11-16 September 2003. The IBC exhibition is one of the world's premier broadcast media events. The exhibition is expected to feature over 1000 companies, covering extensive state of the art technologies. The IBC is the leading event for the creation, management and delivery of content for the entertainment industry. It is the premier forum to show the newest developments in interactive television and convergent content development.