RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innate Lymphoid Cell Engagers (ILCEs): Targeting Innate Lymphoid Cells through a Bispecific Engager for the Resolution of Chronic Inflammation' (ILCEs).

assistant: **Concept**

Chronic inflammatory diseases, such as rheumatoid arthritis (RA) and spondyloarthropathies (SpA) represent a persistent healthcare challenge, requiring life-long management because of treatments with limited long-term efficacy. The key to a breakthrough may lie in the strategic engagement of Innate Lymphoid Cells (ILCs), whose potential in resolving inflammation and reprogramming tissue memory emerges from the recent ERC-funded research by Rauber et al. (2024). The study published in Nature Immunology elucidates the physiological function of ILCs to control inflammation. Building on this, we propose an innovative ILC engager (ILCE), aiming to harness natural pathways of resolution of inflammation and to offer a significant improvement over anti-cytokine therapies. Our approach bypasses generalized immunosuppression and thereby reduces the risk of infection by maintaining the body's acute inflammatory response. The development of an ILCE holds the promise to gain a new class of precise and efficacious therapeutics for chronic inflammatory diseases, revolutionizing patient outcomes by tailoring  treatments to the nuanced pathophysiology of inflammation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Implications of copy number variants of the genome in the etiology and progression of colorectal cancer' (COLONGEVA).

assistant: **Innovation**

Cancer susceptibility genes involved in Mendelian inherited forms of colorectal cancer (CRC) (e.g., Lynch Syndrome) may account for only 5% of all CRC cases. However, increased cancer risk because of a positive family history may vary from 25 up to 40%, and the genetic basis for this familial aggregation remains largely unknown. Recently, high-resolution genomic strategies have revealed an unprecedented form of structural variation of the genome in the normal population, including copy number variants (CNV) and insertion-deletion polymorphisms (indels), which could predispose and influence on the progression of the disease. Using an array of genomic approaches and next-generation sequencing-based techniques, this proposal aims to discern the role of structural variants of the genome in the susceptibility and tumorigenesis in families with high risk of CRC, and to provide insights into how genome-wide copy number analysis can be used as a strategy to identify novel cancer-predisposing genes and mechanisms. In addition, based on gene expression profiling, we will interrogate the function of genes involved in CNVs and their consequences on gene expression in CRC cells. Furthermore, it is possible that CNV profiles and other genetic variants are associated with clinical conditions. This study will infer the genetic causes and mechanisms that lead to drug resistance in CRC patients. Using whole exome-sequencing, we will determine whether patients with responding and non-responding colorectal tumors to chemoradiotherapy treatment (e.g., 5-fluorouracil) show a different distribution of mutations, in their germline and somatically, and as a consequence which cellular pathways result commonly afflicted. Thus, this project will generate a landscape of genetic alterations associat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative Dual mEmbrAne fueL Cell' in the context of a Seventh Framework call.

assistant: **Objectives**

IDEAL-Cell proposes to develop a new innovative and competitive concept of a high temperature Fuel Cell, operated in the range 600-700°C, based on the junction between a PCFC anode/electrolyte part and a SOFC electrolyte/cathode, through a mixed H2 and O2 conducting porous ceramic membrane. Protons created at the anode progress toward the central membrane to meet with Oxygen ions created at the cathode, to form water, which is evacuated through the interconnected porosity network. Therefore, in our concept, Hydrogen, Oxygen and water are located in 3 independent chambers, which allows avoiding all the detrimental consequences linked to the presence of water at electrodes (low fuel and electrical efficiency, interconnect corrosion, need for a gas counter-flow…). The IDEAL-Cell concept brings a considerable enhancement of the overall system efficiency (fine-tuning of the catalytic properties of the electrode, possibility of applying a pressure on both the electrode sides, more simpler and compact stack-design with less sophisticated interconnects, more efficient pre-heating of gas, simplified heat exchange system for co-generation, availability of high quality pure water for vaporeforming …). This 4-year project, divided in 2 parts, is organized so that the risk is minimized at each step. The first 2 years will focus on the proof of the concept with routine materials; the last 2 years will be dedicated to the development of an optimized short-stack with advanced materials and architecture. The project work programme is based on extensive theory and modelling, material development, testing techniques development, benchmarking and dissemination of the knowledge acquired during the duration of the project. The best European teams have been carefully selected according to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sinusway- a revolutionary single-use endoscope device for treatment of severe sinuses infection (Sinusitis)' (Sinusitis), addressing dissemination and exploitation.

assistant: **Impact**

Rhinosinusitis (RS) (better known as sinusitis) is a severe infection caused when the tiny air pockets around the bones of the nose are filled with germs or fluids. Sinusitis affects more than 80 million people in Europe and 803 million around the world, making it one of the most common health problems worldwide. Sinusitis sufferers carry a huge burden of symptoms, including challenging breathing, headaches, facial pain, nasal congestions, fever and disrupted sleep all of which drastically affects their quality of life. Since thin sinus walls share a border with the surrounding tissue, sinus infection can spread beyond the border of sinuses and cause major complications to eyes, brain and even cause asthma and bone infections. Hence, proper diagnosis and management of sinusitis is essential to prevent the risk of complications. However, current drawbacks of tools available to physicians make diagnosis and management of sinusitis very difficult. Sinusway is a novel lightweight single use endoscope for patients suffering from sinusitis. Sinusway is the first one that allows the tip of the endoscope to turn sharply into lumens in the sinus and then advance in the direction of the angulation which was set, beyond the point of angulation and independently from it.  This allows to reach more than 90% of the sinus area. Using an intuitive easy-to-use ergonomics, ENT physicians have full control over the direction of the advancement of the endoscope, without the need of the support from the anatomy to do so. As such, Sinusway represents a revolutionary solution to a global market expected to grow to €20.86 billion by 2022.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Women and Press in the Republican and Democratic Movements of Portugal, Mexico, and Spain (1900-1914).' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The general objective of this research project is to recover and analyze, both quantitatively and qualitatively, the female contribution to the debates and transmission of republican and democratic principles, values, and projects between 1900 and 1914 through their journalistic activity, adopting a plurinational geographical approach that includes three Atlantic countries: Portugal, Mexico, and Spain. The adoption of this Atlantic approach not only allows for the appreciation of the possible circulation of ideas and the mobility of some of their spokespersons within these territories but also overcomes the limitations sometimes imposed by national frameworks and provides insight into how women participated in the broader debate on republicanism and democracy taking place at the time.


**Keywords:** Republicanism, Democracy, atlantic history, circulation of ideas and proyects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Proactive Operational Intelligence  Cybersecurity Platform for the Financial Services Industry', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

REDSENTRY aims to provide a flexible, scalable and open solution to the ever-changing threat landscape faced by the financial services sector. The threats faced by the financial services industry are varied and constantly evolving and cybercrime is the 2nd most reported type of crime by financial institutions according to PWC.  The potential impact of cybersecurity incidents is tremendous as the sector accounts for €731 billion (5.9%) of the EU’s total GVA (Gross Value Added) and employs 6.4 million people.  The size, potential for monetary gain and overall societal disruption of make the financial services sector a prime target for cyber criminals using the latest techniques which are often undetectable with current solutions. A recent report by GreAT  found 140 enterprises, including banks, affected by “file-less attacks” which use the system’s RAM to execute malicious code and are currently undetectable through conventional means. This is only one example of the numerous ways in which cyber criminals are innovating and developing new means of bypassing cybersecurity measures. REDSENTRY will provide a real-time networking monitoring platform to provide the ability to detect and manage any type of threat. By focusing on network monitoring REDSENTRY will provide enable financial sector institutions to manage their infrastructure in real time, proactively and with automatic security response protocols.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Topological Crystalline Insulator Nanowires'.

assistant: **Objectives**

The key challenge in quantum computation is decoherence - the collapse of a quantum state due to local perturbations. In this proposal we address this challenge by developing a new nanomaterials system, which forms the core of a future topological quantum computer. In a topological quantum bit, information is encoded in Majorana modes, which are topologically protected by a local symmetry and therefore have long coherence times.In this project we develop a new state of matter -topological crystalline insulator nanowires- in which the topology is defined by the band inversion and the crystal symmetry of the material. Therefore, these topological states should be exceptionally robust. Further, we integrate strong superconductors on these nanowires. These two features together should increase the energy scales of the system compared to current state-of-the-art devices, and therefore lead to stable and electrically-isolated Majorana states.In this project we develop new crystal growth strategies, which enable to grow out-of-thermodynamic equilibrium structures. We will be the first to employ Molecular Beam Epitaxy (MBE) to precisely tune the SnTe nanowire growth conditions. We use the directionality offered by MBE to shadow-grow superconductors on one nanowire facet. The in-situ ultra-high-vacuum growth of hybrid semiconductor/superconductor devices will result in unprecedented device quality.Due to the increased energy scales, experiments, which have been unattainable so far, come within reach. We use this new materials platform to demonstrate entanglement of two Majorana modes at the ends of a nanowire. This quantum teleportation is a groundbreaking experiment and is the key of a topological quantum computer.


**Keywords:** Nanowire, Semiconductor, Superconductor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Renal Chloride Chanels and Blood Pressure Regulation' under Horizon 2020.

assistant: **Concept**

Hypertension, or elevated arterial blood pressure, is a significant global health concern.  A major cause of hypertension is the abnormality in salt (NaCl) handling in distal nephron segments within kidney.  Although there has been long a debate with regard to the relative importance of Na+ vs. Cl- in inducing salt-sensitive hypertension, previous research demonstrated that excess intake of Cl- could lead to severe salt-sensitive hypertension.  Thus, better understanding on molecular mechanisms of renal Cl- handling would provide useful insights in treatment of hypertension.  Previous studies largely focused on the identification and regulation of apically expressed Cl- transporters, including Na+-Cl- cotransporter, Na+-K+-2Cl- cotransporter (NKCC1/NKCC2) and pendrin, but mechanisms and regulation of Cl- transporters on basolateral membranes (i.e. an exit of Cl- into the interstitial space) remains poorly described.  Thus, the current proposal will investigate the physiological role of basolateral Cl- channel distributed in distal nephron, specifically ClC-kb.  Using a transgenic ClC-kb knockout line of mice, I propose to investigate the physiological role of this channel within isolated tubule and at the whole animal level.  In addition, ClC-kb channel is known to interact with a functional β-subunit, barttin, and this interaction could affect Cl- conductance.  I propose to investigate the molecular mechanisms by which barttin can affect ClC-kb-mediated chloride transport.  The proposed studies will shed new insights into the molecular mechanisms of Cl- reabsorption in distal nephron, and could provide a basis for novel approach in treatment of hypertension.


**Keywords:** Hypertension, Ion transport, Chloride Channels, Sodium transport, Kidney
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'iSMILE - integrated scalable microLED engines'.

assistant: **Innovation**

Today´s microelectronics is suffering from the fact that silicon cannot emit light. Otherwise, technological road blockers like the communication bottleneck of microprocessors or like bulky displays hindering the rocket start of augmented reality could easily be overcome.  The EIC accelerator project i`SMILE will bring light to microelectronics. Our goal is to be an enabler for a natural integration of microelectronics with microphotonics. I`SMILE will establish a GaN cleanroom in order to be completely independent from non-European manufacturers. Customized microLED modules for AR-glasses will be a first product. Beyond that, i`SMILE will be the basis for establishing the worldwide first GaN foundry, making GaN technology fully accessible to European innovators, leading to a “democratisation of microLED technology”. Much like TSMC from Taiwan who is now the world´s largest foundry for silicon CMOS technology, we dream of QubeDot developing into the “TSMC for GaN” in the future.After completion of the project, QubeDot will be able to produce microLED displays and customer-specific microLEDs with the highest precision within its own clean room environment using ISO9001 certified process flows. With single-shift utilization, the pilot line will be able to generate an output translating into potential annual sales of up to 25 M€, with an estimated margin of 30+%. While other very large companies do not adapt their production processes for medium-size batches, QubeDot has understood the interaction of essential parameters in the processing of GaN through intensive research and development work. This enables the production of a wide variety of microLED architectures in terms of quantity, size, shape, emission color and package.While other very large companies depend on semic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BIOchemical and genetic dissection of control of plant mineral NUTrition' to be submitted under Seventh Framework.

assistant: **Abstract**

The main objective of BIONUT-ITN is to provide state-of-the-art training for young researchers in the highly strategic field of plant nutrition and productivity through an international programme of research, training and transfer of knowledge. The interdisciplinary training will include biochemical and genetic technology in the laboratory with field agronomy and high throughput phenotyping technologies, combining inputs from academia and industry. The training will be based around a research project which will address important biological questions using model plants and the major crop species, wheat and rice, with the overall goal of increasing the understanding of genetic control of nutrient use efficiency of plants and thus addressing one of the major challenges of European society, global food security. The overarching and long term scientific questions of BIONUT-ITN are: what controls nutrient use efficiency of plants and how can we use this knowledge to generate crop plants with optimised yields without increasing inputs? BIONUT-ITN addresses this by bringing together a group of world class researchers to adopt a multidisciplinary approach and to provide the necessary breadth of academic as well as industrial expertise essential to training and transfer of knowledge. The scientific themes providing the backbone of our training activities are (1) Genetic control of nutrient use efficiency, (2) Function of new genes affecting plant mineral nutrition, and (3) From the laboratory to the field. By bringing complementary intersectoral providers of research training together into a cohesive network, BIONUT-ITN will move the biologists working in the field of plant nutrition closer to the end-users of the research achievements including agroindustry, breeders and farmers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Laying the Foundations for an Era-Net on Foresight the Society'.

assistant: **Innovation**

The objective of the intended Specific Support Action (SSA) project is to execute a consultation process which leads to the agreement upon on submitting in a latter step, a proposal for an ERA-Net Coordination Action in the area of Foresight and Society . The implementation of the proposed work is based on the Specific Support Action (SSA) instrument of FP6 and the project bears the acronym-coded title: ForSociety - Laying the foundations for an ERA-NET on Foresight and Society.More specifically the primary objectives of the SSA ForSociety are to: i.Gather intelligence about Foresight and Society participation among the project partners and the rest of Europe; ii.identify a set of strategic and joint activities suitable for the ERA-Net Coordination Actions implementation mode; iii.widen the group of participants for the ForSociety Co-ordination actions in order to reach widest possible participation in the ERA-Net scheme; iv.establish such knowledge and understanding about the competencies and interests of each partner in such a way that that the partners will be able to allocate the management of each task of the ERA-Net Co-operation Action to a suitable participant; The ERA-Net Co-ordination Action envisaged, will support and strengthen the interactions between Foresight, S&T policy making, Society and citizens for the promotion of proactive networking and priority setting for the future; this with the aim of providing effective support on the one hand to European scientific and technological integration - especially in view of the enlarged EU and operational implementation of Article 169- and on the other hand, the emergence or development of a European knowledge-based society. Key-instruments to be applied by the proposed SSA members in order to establish co-operati