RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Models in Space Systems: Integration, Operation, and Networking' to be submitted under Horizon 2020.

assistant: **Abstract**

Spacecraft must work robustly in the presence of uncertainties such as random hardware faults, operator mistakes, space debris, and radiation. Classic space missions address uncertainty via large safety margins and bult-in redundancy, leading to a spiral of increasing cost and complexity. A recent trend is the small-business commercialisation of space using commercial-off-the-shelf components for networked constellations of small satellites. This ""New Space"" approach reduces component weight, size, price, and lead time, and makes innovation increasingly driven by software. This pertains especially to resource management and data handling, while simpler components and new interactions increase uncertainty, and come with less reliable parts. Thus, overall mission connectivity, efficiency, dependability and safety in the New Space needs to be achieved on a system level - for which there is no systematic approach yet. This is partly rooted in the empirical focus of many teams, and partly in a lack of easy-to-use methods to model, analyse, and guarantee system-level dependability. This interdisciplinary project sets out to solve this space engineering problem by exploiting highly advanced techniques from the forefront of computing science research, especially model-based algorithmics. We strive for sound and efficient software tools for the development of dependable, networked, and resource-aware New Space missions. For this, the MISSION project will develop an integrated model-based technology to establish and maintain system-level properties of critical space mission parameters. A strong consortium of excellent academic and industrial partners in Europe, Argentina, and China has agreed on a joint research and knowledge sharing agenda that will foster a shared culture of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New Electronics Concept: Wafer-Scale Epitaxial Graphene' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The concept of this project is to unlock the potential of epitaxial graphene on silicon carbide (SiC) for development of scalable electronics with the view to develop graphene-based devices & circuits with a non-conventional functionality. Our strategy is to explore two promising directions of graphene-based technology: (i) the development of large-scale graphene wafers for manufacturing high-density of devices on a single SiC wafer, and (ii) the development of hybrid circuits for applications of graphene in spintronics and metrology by exploiting the flexibility for design offered by the large area of graphene on SiC. The consortium of bidders brings together groups with complementary expertise and substantial achievements in the relevant area of graphene research and nanotechnology in general.<br/>The objectives are to (1) reliably produce large-area graphene with a controlled carrier density and improved transport characteristics; (2) pattern graphene for applications using industrial nanostructuring and nanofabrication methods, aiming at high integration densities with a good yield of working devices; (3) produce a prototype for a graphene-based Quantum Hall Resistance standard with characteristics surpassing existing silicon- and GaAs-based devices; (4) develop a pilot version of spintronic devices of epitaxial graphene; (5) start exploiting the commercial potential of graphene by establishing a start-up company that will produce graphene wafers for users outside this consortium.<br/>These objectives relate directly to major parts of the call, namely, the need for new circuit architechtures, metrology and characterization techniques; new device structures for non-Si and Si based advanced integrated components to add functionality to circuits and (sub)systems; and n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Compounds and genes for enhanced protein assimilation and digestibility of forage legumes' (CAGED).

assistant: **Concept**

The objective of this project is to produce bloat-free forage legumes with improved assimllation of proteins. A preliminary investigation of the nutritive value of populations (varieties, landraces, spontaneous populations) of the most cultivated species (Medicago sativa, Trifolium repens, Lotus corniculatus) will be performed and the relevance of condensed tannins in affecting protein degradation and forage digestibility will be assessed for each species. Because an excess of condensed tannins could have a negative effect on palatability and digestibility their optimal concentration and structure will be established in various forage species through different approaches. Transformed genotypes of Lotus corniculatus altered for their content in condensed tannins will be exploited for determining the effect of these compounds on forage quality and for isolating, through cdna subtraction between tannin rich and tannin suppressed derived transgene, the genes involved in their synthesis. Condensed tannins are terminal compounds of the flavonoid biosynthetic pathway and the genes coding for the enzymes of this branch of the pathway from leucocyanidin to condensed tannins are not yet isolated and cloned in any species. The sequences obtained after subtraction will be tested for their real involvement in tannin synthesis through experiments of transformation of Lotus with the recovered genes in antisense orientation. This part of the investigation will be carried out utilising Agrobacterium rhizogenes as transformation vector. This strategy will allow an early evaluation of the effect of transformation on condensed tannin biosynthesis in hairy roots. Confirmed sequences will be utilised for the recovery of full length messenger by screening Lotus cdna libraries. The recovered g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetic patients with normoalbuminuria' (PRIORITY).

assistant: **Innovation**

Patients with diabetes are at risk of developing diabetic nephropathy, which will ultimately result in the requirement for renal replacement therapy and is also associated with high cardiovascular morbidity and mortality. Detection of low concentrations of albuminuria in urine (microalbuminuria) is the current clinical standard for detecting those at significant risk and targeting preventive treatment. However, albuminuria is of low specificity at early stages of disease, and of considerable biological variability, hence a poor predictor at early stages of disease. In two independent studies we have demonstrated that urinary proteomics offers the prospect of detecting nephropathy earlier in the preclinical phase, enabling targeted treatment at an earlier stage. We propose to assess the potential of this technology to identify normoalbuminuric patients at risk and to target therapy with an aldosterone receptor antagonist (spironolactone) as add-on to recommended therapy including angiotensin converting enzyme (ACE) inhibition or angiotensin II receptor blockers (ARBs) according to national guidelines. We will test the following hypotheses: (1) urinary proteomics predicts progression of albuminuria (as a surrogate marker for the development of overt nephropathy) in a cohort of 3280 type 2 diabetic patients with normal urinary albumin excretion, and (2) early initiation of intensive preventive therapy directed by urinary proteomics reduces progression of albuminuria in those 20 % at high risk and thereby delay progression to overt nephropathy and spare treatment for those with low risk, paving the way of personalised medicine. This will be the first biomarker-directed therapy trial for primary prevention of diabetic kidney disease. Additional clinical and circulating bioma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Every smell you take – Smell-induced conditioning of the immune system during infections' under Horizon Europe.

assistant: **Concept**

The nervous and immune systems are the body’s primary sensory interfaces, perceiving and responding to environmental stimuli. Both systems can recall past challenges, enabling them to mount responses that anticipate and adapt to ever-changing situation.Recent research indicates that the brain can recall past infections, forming a new axis between neurological memory and immune response. A notable example of such interaction is Pavlovian or classical conditioning, where organisms learn the timing and causal relationships between internal and external stimuli, enabling them to prepare responses before significant events even occur. Importantly, pioneering studies have shown that the immune system can also be conditioned. However, it is still unclear whether conditioning can be used to boostimmune response upon pathogen reencounter or during revaccinations. Furthermore, the fundamental neuroimmune mechanisms that promote conditioning remain largely unexplored.Although Pavlov initially used a bell to condition dogs, other stimuli, e.g. smells, can be even more effective due to their strong connection to memory and emotion. For example, the scent of freshly baked cookies can evoke vivid childhood memories. So, could the application of smell during a viral infection or vaccination trigger a stronger secondary immune response? Therefore, we hypothesize that an olfactory stimulus received during a primary infection or vaccination enhances the immune response after subsequent encounters.Thus, we propose combining advanced immunological and neuroscience techniques to understand how multiorgan, neuro-immune circuits regulate the immune response after conditioning with odor. Furthermore, we will investigate whether activating these circuits can inhibit pathogen replication, conside
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Second and third funding line in 2016-2017 for the establishment of a European SST service provision function' in the context of a Horizon 2020 call.

assistant: **Objectives**

2-3SST2016-17 is the ""Second and third funding line in 2016 and 2017 for the further development of a European SST Service provision function” project proposed under H2020 funding by the EUSST Consortium composed of five participating Member States in coordination with the EU SatCen. The project starts on 01/10/2017 and is composed of a Part I planned for a duration of 27 months until 31/12/2019 and Part II planned for a duration of 39 months until 31/12/2020, which indeed constitutes the end date of the project. The aim is twofold: (1) to continue to support the pooling of national resources on the SST objectives outlined in the Decision No 541/2014/EU in accordance with the Action Plan outlined in the EUSSTFPA and (2) continue to support the SST evolution needs in line with the objectives and challenges of Horizon 2020 related to protecting Europe´s investment made in space infrastructure.This will be performed by (1) consolidating the EUSST functions and SST capability at European level, supported by the implementation of an Integrated Management for all SST2016-17 project whose core elements are in 2-3SST2016-17 and (2) the improvement of the EUSST functions and capabilities, in accordance with the Action Plan outlined in the EUSSTFPA, consisting in both studies and upgrades of identified sensors controlled by the EUSST Member States with the aim to investigate and perform improvement of the EUSST functions and capabilities.  The project is organised in 9 Work Packages (Project Administration, Projects´ Management, Governance, Consolidation of the sensor function, Consolidation of the processing function, Consolidation of the service function and user coordination, Studies on Future Environment and Trade-off, Studies on sensor and processing capabilities, Developme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Purification. cloning and expression of a 65 kd mdrl-like protein from secretory granules of pancreatic acinar cells and beta-cells'.

assistant: **Concept**

In pancreatic canard cells and pancreatic Beta-cells, a 65 kid marl-like protein regulates ion conductances in secretary granules that contribute to exocytosis The aim of the research project is the purification, cloning and functional expression of the 65 kid marl -like protein.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Intercellular trading in nucleotide metabolism: an emerging target'.

assistant: **Concept**

Anticancer therapy is >70 years old, and nucleotides are the oldest target in cancer treatment. Despite its long history, this treatment suffers high rates of resistance and toxicity. What are the reasons? A cell can gain nucleotides via de novo synthesis (DNS) or from salvage pathways. DNS inhibition can be bypassed by nucleotides produced by surrounding cells or distant organs, causing resistance. Cancer cells were traditionally studied in isolation, with (bulk) techniques precluding identification of cell type-specific targets, causing toxicity. To date, the cellular sources of nucleotides in healthy and tumor tissues are poorly characterized. Can the complexity of metabolic crosstalk in tissues be captured by the traditional means? I hypothesize that cancer and stromal cells differ in how they utilize nucleic acid building blocks from external and internal sources. A single cell resolution is needed to disentangle their interactions, and inhibition of both DNS and cancer-specific salvage is required for a successful blockade. I aim to define the nucleotide sources in heathy tissues and tumors, characterize their adaptations to DNS blockade to uncover the network of metabolic interactions in tissues and find effective and specific combinations of targets. To reach this goal, I will use a unique combination of single cell multi-omics and tailored mouse models, an expertise and tools that I took the lead to set up. I will selectively disable DNS in the stroma (host mouse) and in cancer cells (syngeneic lung tumors) to generate tumors dependent on internally or externally produced nucleotides. In an integrative approach using spatial and single cell transcriptomics & metabolomics in situ, and functional genetic screen, I will search for targetable metabolic vulnerabilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Standard Interface for Robotic Manipulation of Payloads in Future Space Missions', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The main objective is to develop a standard interface that considers a set of connections that allow coupling of payload to manipulators and payload to other payload. The realization of a modular reconfigurable system depends, among other things, on interfaces, that includes mechanical interfaces connecting the blocks to one other, electrical interface for power transmission, thermal interfaces for heat regulation and interfaces to transmit data throughout the satellite.Multi--‐functional “Intelligent” interface will be considered to interconnect building blocks and also to connect to the satellite with a servicer.The standard interface will require standardization and modularization of the different components in an integrated form (where mechanical, thermal, electrical, data connections are combined) or a separated form. The standard interface shall allow building up large clusters of modules. APMs are considered for demonstration, validation and verification of all properties of the standard interface. An end-effector for a robotic manipulator will be designed according to the layout of the standard interface. The Modular Interface will take into account long duration missions, no logistics support and missions composed of multiple payloads and architectures. Main benefits:- Improve operational capacity- Reduced logistics with common and modular spares- Common maintenance standards- IF architecture flexibility: common infrastructure needed to support the modular design- Mission flexibility (configuration changes)- Standardizes mechanical, data, electrical, thermal Interfaces- Keep existing standards where applicable- Introduce in the design aspects related to interchangeability and interoperabilityThe standard interfaces will allow to develop the SRC end goals. The o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Enhanced Safety Coming from Appropriate Police Enforcement'.

assistant: **Objectives**

The aim of ESCAPE is identify important areas of traffic and driver non-compliant behaviour and to assess the potential of enforcement tools, both traditional and innovative, to improve compliance and thus contribute to safety on European roads. ESCAPE will prepare the groundwork for implementing European wide demonstration projects in enforcement within the 5th framework program. More specifically, ESCAPE will consolidate existing information as well as produce new data with respect to the following inter-related enforcement issues in Europe (the workpackages that deal with each objective are in brackets): 1. What are the levels of non-compliance with traffic laws (WP2, WP5);2. What is the contribution of non-compliance to accidents (WP2);3. What new areas of non-compliance or enforcement issues emerge in Europe of the 90's (WP1, WP2);4. How is enforcement carried out in practice in different countries (WP1, WP3, WP4);5. What are the constraints for efficient enforcement, in different countries (WP1, WP3, WP4, WP5);6. What role non-police institutions and functions have in enforcement (WP3); 7. How can conventional enforcement be improved (WP1, WP3, WP4); 8. What alternatives to police enforcement are there (WP3);9. What new tools and technologies for effective enforcement are there (WP1, WP4); 10. How will such tools be accepted by individuals, the public, and institutions in different countries (WP1, WP5);11. What areas of enforcement, and by which tools, appear to be cost effective (WP1); 12. How should non-compliance, and enforcement effectiveness, be monitored and assessed (WP6). %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Formation and high-resolution spectroscopic characterization of carbonic acid' (HRMSCA), addressing dissemination and exploitation.

assistant: **Impact**

The main greenhouse gases in our atmosphere are water and carbon dioxide. Much attention is given to the study of the physicochemical properties of these molecules. However, there are no studies aimed at studying the formation of carbonic acid from these molecules in the atmosphere. The objective of this project is to analyze the development of carbonic acid (H2CO3) and its possible formation from CO2 and H2O in the gas phase. It is anticipated that the aggregation and large vibrational excitation will favor the conversion of the CO2-H2O complex into H2CO3. To test this theoretical prediction, our project will employ a distinctive combination of supersonic expansion, mass spectrometry, intracavity infrared excitation, and microwave sensing.


**Keywords:** High-resolution molecular spectroscopy,  Cavity ring-down spectroscopy,  Chirp pulse microwave spectroscopy,  Supersonic expansion,  Van der Waals complexes,  Carbonic acid