RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms of stem cell proliferation and senescence in the aged and damaged mouse brain', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Stem cell self-renewal is a consequence of the ability to proliferate indefinitely while maintaining pluripotency. In the adult brain, neural stem cells continuously produce neurons, and its importance for memory and repair after neurodegeneration and brain damage has been extensively investigated. However, adult neurogenesis is limited and significantly decreases throughout life. With aging, increased senescence greatly restrains the neurogenic potential of aged stem cells. Senescence induction is critically controlled by the INK4a/Arf locus, but the mechanisms of senescence induction are largely unknown. It is essential to understand the mechanisms involved in the control of stem cell proliferation and senescence for the development of stem cell-based therapies. The host laboratory identified that embryonic and peripheral neural stem cell proliferation is regulated by a novel mechanism that involves S-phase cell cycle arrest, GABA signaling and the histone variant H2AX (Andäng et al Nature 2008). This proposal aims to investigate whether GABAAR and H2AX-mediated modulation of stem cell proliferation is a factor in age-related decline in neurogenesis, and if this pathway could be modulated towards boosting neurogenesis following neurodegeneration or damage. H2AX is also involved in senescence, being activated following telomere erosion.  We propose to investigate the mechanisms of senescence induction and the interaction between critical regulators of cell cycle. This will provide new information on the conserved and unique pathways involved in the control of stem cell proliferation and senescence. The investigation of the mechanisms involved in age-related neurogenic decline and how neurogenesis can be boosted may open the way for new clinically relevant strategies in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fundamental rights and private law in the european union' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This project will offer young researchers the opportunity to engage in both doctoral and post -doctoral research in the field of European and comparative law. They will be asked to investigate a specific topic with reference to the relationship between fundamental rights and private law. Most of the topics will concentrate on private law, but it will also be possible to conduct research into wider issues of constitutional or European law. Every researcher is asked to compare the law of at least two European countries (the home country and the employing country). S/he will be tutored by a professor from the university at which s/he will be based for the main part of the research, and, additionally, by associated tutors from the partner universities of the countries involved in her or his specific comparative research. Each unit of the network will offer the needed assistance for the researchers, so that they will have access to both an expert in private law and one in constitutional and/ or in European law. The researchers are required to attend seminars on the subject they are working on. Special seminars may be offered by the participating Law Faculties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chronic Stress Biomarkers for Early Detection and Prevention of Burnout', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In 2013, the costs of work-related depression in the EU-27 was estimated to be €617 billion annually , taking in account costs to employers resulting from absenteeism (€272 billion), loss of productivity (€242 billion), healthcare costs (€63 billion) and social welfare costs (€39 billion). The project focuses on the early detection of work-related psychological stress resulting in negative health outcomes, such as burnout or depression.  • In phase 1, the project will validate the technical and commercial feasibility of a non-obtrusive smartphone-based solution able to detect stress based on the analysis of speech, sleep and typing behaviour. The project will establish the market interest (competitive analysis, willingness to pay) and recruit corporate organizations willing to participate to clinical trials in phase 2. • In phase 2, the project will implement a clinical trial in order to demonstrate the validity of the existing solution prototype based on the stress biomarkers researched in phase 1. The solution will be tested with adult subjects against other known stress biomarker sensors.One of the key innovations of the project is the use of speech analysis to evaluate chronic stress by using a dual approach: first, recognize stressed speech using two nonlinear feature models and second, recognize emotion profiles in order to assess mental resilience. The analysis follows a machine learning approach by identifying relevant features to build classifiers which are then trained on a suitable data set. The platform built in this project will also be used to develop an ecosystem of partner companies (e.g. wearable suppliers, online coaching services) that can reuse SOMA Analytics algorithms inside their own product offerings, thus driving further European innovation in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards a decentred history of the Middle East: Transborder spaces, circulations, frontier effects and state formation, 1920-1946' under Horizon 2020.

assistant: **Concept**

While the crisis of the territorial nation-state in the Middle East has once again been brought to a head by the wars in Iraq and Syria, it cannot be simply understood as the logical consequence of an imported political construction. Based on two epistemological notions – borderlands as histoire-problème (history-as-problem) and the co-production of borders between state and society – this research project proposes to rethink the classical historical narrative about the emergence of the post-Ottoman Middle East. Taking its cue from trans-border phenomena and thus paying attention to the circulation of people, goods and ideas as well as to everyday encounters between local actors and state representatives, the project will be guided by four principle objectives to offer:•A socio-historical analysis of state violence in the borderlands of the Middle East;•An examination of the capacity of border populations to create the history of the borderlands, nation-states, and the region as a whole;•A study of the frontier effects based around the notions of subjectivity, space and time, and involving various levels of observation (macro, meso and micro) in order to identify the ruptures and continuities evoked by the delineation of new borderlines; and •A historical lens through which to make sense of current events in Syria and Iraq, and possibly orient conflict-resolution practitioners. Through the exploitation of a wide range of sources (diplomatic, administrative and military records, missionary documents, newspapers) and by looking at the social construction of international frontiers at the borderlands located between Turkey, Iraq and Syria in the interwar era, the research project will provide a much more holistic yet finely-grained understanding of the formation of the ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Progress in Clinical the Experimental Angiology Polish Angiological Conference 2002' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Advances in vascular medicine and technology make the organization of interdisciplinary conferences for exchange of knowledge and experience necessary. Vascular disease in the various clinical forms is a leading mortality cause in Europe. The international society tasks in prevention, early diagnosis and therapy should be overworked to improve the life quality and reduce the health-care costs. Integration of highly specialised healthcare in cardiology, neurology, vascular surgery etc. is a domain of angelology. It results in the holistic patient care with an interdisciplinary approach. Introducing the international guidelines in venous thromboembolic and peripheral vascular disease in candidate countries will improve the patient care and help to integrate the uniform European standards. Popularising them among physicians and general public will decrease overall mortality rate and uniform the pre-accession and EU countries healthcare level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Estimation of Neural Code from the Electroencephalogram (EEG)' (EEG), addressing dissemination and exploitation.

assistant: **Impact**

The electroencephalogram (EEG) is one of the most important non-invasive brain imaging tools in neuroscience and in the clinic, but surprisingly little is known about the features of neural circuit activity that give rise to the EEG. The challenge is to explain the functional and anatomical configurations, e.g., the neural interactions among different classes of cells, that produce the diverse spatial, spectral and temporal EEG features linked to cognition and neurological diseases. By means of an interdisciplinary approach, combing advanced theoretical modeling with state-of-the-art multiscale neurophysiology and interventional techniques, I will address the above challenge. I will develop rigorous mathematical tools to disambiguate the EEG and robustly interpret it in terms of specific neural features (e.g., firing rate). Such features are key elements in determining the microcircuit configuration and have been documented to contribute to brain disorders such as schizophrenia and Autism Spectrum Disorders (ASD). First, I will develop neural network models that include the key components of cortical microcircuits. I will then turn these models into accurate EEG analysis tools by fitting them to empirical data to “invert”, or translate back, the EEG into an estimate of the neural parameters. In particular, I am interested in studying the relationship of the EEG with spiking activity and synchrony of excitatory and inhibitory populations. The experiments will record simultaneously EEG and intracortical neural activity in mice, combined with optogenetic tools that can determine the contributions of specific classes of cells and specific patterns of activity in cells to different EEG features. The analysis tools developed in this project will be used to infer neural circui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Development of Prosocial behaviour: Evolutionary and Ontogenetic perspectives' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In this project, the psychological mechanisms underlying human prosocial behaviour are studied in a game-theoretical context. This framework has frequently been used to investigate cooperation between unrelated strangers. A lexicographical social heuristic is proposed, which models the human decision strategies likely to be used in such a context. This heuristic draws on different kinds of social information: knowledge about past behaviour of the interaction partner, probability of future interaction, and grow up membership of the partner, all of which have been identified to independently further prosocial behaviour by evolutionary, economic, and psychological research.In three studies it is investigated:(1) whether the decisions of adult players of a repeated prisoner's dilemma game can be modelled by the social heuristic, and(2) if the use of this social heuristic is subject to ontogenetic changes.Furthermore, group membership is modified by assigning participants either to trivial social categories or categories they encounter in real life. It is argued that understanding social information about group membership is itself subject to ontogenetic change and should therefore influence children's decision strategies. The work proposed here provides a novel collaboration between anthropology, experimental economics, evolutionary theory, and social and developmental psychology. The project will promote the integration of scientific concepts across fields and levels of analysis, thereby developing an infrastructure for future interdisciplinary work on human cooperation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovation management using appropriate tools and measurements for smes (IMPETUS)' (IMPETUS).

assistant: **Innovation**

The objective of the IMPETUS project is to provide pragmatic, low-cost and SME specific methods and tools to generate and assess ideas and innovations as well as to plan innovation activities for the formulation of an innovative and progressive future product respectively service, reflected on technological trends and market (consumer) demands. The IMPETUS methods and tools will provide instruments to support organisational structures and work practices for the innovation process from idea generation to the planning of innovation activities. This elaborated Innovation Management Scenario will integrate people (human factors), organisational (reference processes), methodological and technological aspects. The consortium contains 4 industrial partners, 3 solution providers and one ICT-solution provider. An industrial supporter group will support and be further expanded during the whole project. Main results will be: IM benchmarking study, IM reference models, IM methodology handbook, a SME-specific IM tool and a road map how to implement sustainable innovation in SMEs"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sensor for terrestrial and Airborne Radio-transmitter rescue search' (STARRS) under Sixth Framework.

assistant: **Objectives**

STARRS project focuses on the design and development of technology for the improvement of environmental risk/crisis management, especially in search and rescue operations (to detect and locate victims' position with a good accuracy as well as to allow alert broadcasting to people in emergency situations.)People in danger will be detected, located and rescued through their basic cellular radio handsets (GSM and UMTS mobile phones). Additionally, headquarters of rescue teams will be able to know the location of rescuers within the intervention area through their professional handsets (TETRA and TETRAPOL mobile handsets).The STARRS project will study and develop two test beds (one for helicopter and one for a pedestrian rescuer), which will be tested and evaluated through field trials, in order to get operational performances. The STARRS testbeds will be autonomous from network, and then can be used in real disasters situations.In order to define the multi path location algorithms of the test beds, a signal propagation study in some specific environments (as urban collapsed building) will be realized first. Then a system study will define detection and location protocols for GSM/UTMS and TETRA/TETRAPOL. In parallel, a signal processing study will aim to design appropriate tracking algorithms. Finally, the two tesbeds, with transmitters, antennas, receiver and processing unit will be developed and tested in selected scenarios.Typical rescue situations/scenarios will be specified by the end users of the project in order to establish the requirements of the STARRS testbeds, such as: search of lost people in mountains areas, fire forests and collapsed buildings.In addition, a new concept, called Over The Air Safety Reply", that will allow automatic reply from rescue team hands
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Next generation drug conjugates for cancer treatment'.

assistant: **Concept**

The optimal potential of chemotherapy, despite being the standard treatment, has not yet been achieved and instead it can lead to adverse toxicological effects as a result of off-target toxicity, as the drug cannot discriminate between healthy and cancerous cells. Small molecule prodrugs help solve this issue thanks to their high efficiency in targeting tumour cells. Syndivia have developed the next-generation Antibody Drug Conjugation platform for development of highly effective small molecule prodrugs for targeted cancer therapies. Two patented technologies are applied in the formulation of the prodrugs delivering higher plasma stability and controlled release at the tumour site resulting in a higher therapeutic efficiency and reduction of off-target toxicity of the chemotherapeutic. The pioneer product SDV1001 is specifically focused on treatment of pancreatic cancer, that accounts for the highest mortality rate among all cancers, over 74% of patients will not survive 1 year from time of diagnosis and 95% will die within 5 years. Preclinical trials have proven the efficacy of the product in which animals treated by SDV1001 displayed 92-100% tumour regression and no noticeable side effects. The Phase 1 project will be focused on establishing a complete and scalable supply chain, verifying the business model and commercialization strategy, planning new collaborations and partnerships, including the ones to implement the next clinical trials stage.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'RoHS compliant, high luminescence, heterostructure nanocrystals for near infrared LEDs and bioimaging.'.

assistant: **Concept**

Colloidal nanocrystals (NCs) that absorb and emit in the near-infrared (NIR) region are of paramount importance in the field of optoelectronics (LEDs, LASERs, solar cells, telecommunication) and biological imaging. However, most of the NIR emitting NCs are based on heavy metals (Pb, Cd, Hg) which are highly toxic and are restricted from widespread use by the European regularity concerns. Therefore, the development of NIR emitting environmentally friendly (Cd/Pb/Hg- free) NCs are of interest. NIRLUMIN proposes a strategy to develop high NIR (1-1.35um) luminescent, stable AInTe2/(Ga/In)2S3/Zn(S/Se) core/shell/shell (CSS) NC heterostructures with controlled bandgap and size in which the outer shells will protect the surface of the core and enhance the photoluminescence quantum yield by passivating the dangling bonds and surface traps while the intermediate layer will stop diffusion to prevent the undesirable bandgap enhancement. Further, the advantages of these NCs will be directly translated into device performance in the LED. For biological imaging, these nanostructures will be over-coated with a ceramic-type alumina shell and transferred to the aqueous phase. The whole work will be conducted in five major steps. (i) Synthesis of CSS NCs, characterization and study of their structural and photophysical properties (ii) Surface functionalization to investigate the surface ligand chemistry on their optical and electrical properties and to make the NCs compatible for devices and bio-application (iii) Cytotoxicity study and bio-imaging using the Alumina coated NCs. (iv) Optoelectronic characterization, to understand the optical and electronic characteristics of the NCs on film. Finally (v) fabrication of LED using these NCs as an active layer and optimization to achieve an ef