RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering the Molecular Mechanism of an Enzymatic Machinery for Glycogen Biosynthesis' (DeciphGYG).

assistant: **Concept**

The biosynthesis of glycogen - glycogenesis - represents a key glucose (and hence energy) storage process across a wide range of organisms. Human glycogenin 1 (hGYG1) is one of the two primary enzymes that initiates the biosynthesis of glycogen, our energy reservoir.  It polymerizes a maltosaccharide chain covalently attached to an enzyme residue, Y195, via a stepwise glycosylation reaction. In the reaction cycle, a dynamic conformational switch between ground and active states induced by one of the enzyme substrates, the sugar donor UDP-glucose, was predicted by structural studies, including a stretch of a critical loop containing Y195, the acceptor arm, and a major movement of a 32-residue lid covering the active site. The T83M mutation, which causes glycogen storage disease (GSD) type XV, makes the enzyme catalytically inactive. The scientific aim of DeciphGYG is to design a new protocol combining a series of both computational techniques (MD, QM/MM MetaD, HREX and BE-MetaD) and experimental results (NMR and crystallography) to unveil the mechanisms of glycogen biosynthesis, including both the glycosylation reaction as well as its coupling with the conformational changes induced by binding of the UDP-glucose donor and acceptor substrates. The experienced researcher (ER), Qinghua Liao will carry out the project in the University of Barcelona under the supervision of Prof. Carme Rovira, who has extensive experience in computational modeling of carbohydrate-active enzymes. Our goal will be shaping the understanding of hGYG1 action fully on glycogen biosynthesis, facilitating drug design against GSD type XV. Moreover, the new protocol will be transferable to other enzymes of interest in glycobiology. Altogether, the DeciphGYG project will allow the ER with a highly compe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advancing Sampling and screening of Extremophile Microorganisms for biodiscovery of Bioactive Compounds from Volcanic, Desert, and Polar Ecosystems', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

XTREMOLIFE will accelerate the bioprospection & biodiscovery of novel extremophile microorganisms. XTREMOLIFE uniqueness is advancing next-generation sampling technologies tailored for extreme conditions: [1] Enhanced Ferrybox for boats (self-operating), [2] novel XTREMOsensor for hand-held use, and [3] automated microscopic imagery identification. In addition, we explore (a large) biodiversity from 3 extremophilic ecosystems by bioprospecting across 5 regions (Route 1), and 5 untapped culture collections (Route 2). We will join those two routes by identifying promising extremophilic microorganisms, produced metabolites, elucidating their bioactivity and structure, optimizing their cultivation, and guaranteeing a baseline pathway towards full exploitation. We will focus on microalgae, cyanobacteria, and their associated microbiome, with a particular interest in bacteria and fungi. The culture collections NORCCA (Norway), ACUF (Italy), BEA (Spain), LEGE-CC (Portugal), TII (Abu Dhabi/UAE) will be prospected. In parallel, we will assess the microbiome and plan sampling from 5 locations: [1] Antarctic, [2] Volcanic aquatic environments in Canary Island, [3]Azores, [4]Mexico, and [5] Abu Dhabi: focusing on hypersaline and extremely hot springs. We will assess the complexity of extremophilic ecology resorting to physical, chemical and biological data gathered. The chemical prospection will cover bioassays in the human, fish and plant health fields. Bioactive compounds will be isolated, and their structure fully characterized. Together, the consortium will select up to 7 different microbial compounds of interest-producing strains to be cultivated at lab scale, followed by a scale up to TRL 5 (feeding an Exploitation Roadmap). Finally, XTREMOLIFE will cover the legal framework
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EU Differentiation, Dominance and Democracy' (EU3D) targeting Horizon 2020.

assistant: **Abstract**

The UK’s decision to leave the EU sent shock-waves through an EU that had gone through an unprecedented process of integration extending for seven decades. Brexit came at a propitious moment for a Union that was still reeling from the effects of the Euro-crisis, the refugee crisis and other challenges, which had exposed the EU’s vulnerabilities, and served as a reminder that member states may not continue on the same integrationist track. It is widely recognised that the EU that emerged from the crises is more differentiated, but it is not clear if differentiation is part of the problem or part of the solution. All political systems are differentiated, but the EU is distinct in the way it is structured, and in the way in which the process of integration is structured and conducted. The EU’s White Paper contains proposals that variously recommend more and less differentiation. EU3D’s main objective is to develop and apply to the EU and beyond a theory of differentiation that specifies the conditions under which differentiation is politically acceptable, institutionally sustainable and democratically legitimate, and the conditions under which it is not, i.e. when conditions of dominance prevail. EU3D does that through comprehensive analyses of the multilevel EU’s institutional and constitutional make-up across a range of policy areas. To properly address this critical issue, EU3D has devised an innovative analytical approach and a framework of research that provides the necessary benchmarks and that moves research well beyond the state-of-the-art, both theoretically and empirically. Further, EU3D will have an impact on the debate on the future of Europe by a) systematically analysing a broad range of proposals; b) mobilising knowledge and competence of a broad and multidi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Polygeneration of energy, fuels and fertilisers from biomass residues and sewage sludge' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The aim of this proposal is to demonstrate high-efficient polygeneration of electricity, heat, solid fuels and high-value compost/ fertilisers from sewage sludge and greenery waste mixed to biomass residues, thereby offering a new, safe, environmentally friendly and cost-effective path for the disposal of sewage sludge, maximising energy output, greenhouse gas reduction, cost-effectiveness and new chances for SME. Compared to the existing routes of sewage sludge treatment, the proposed concept allows achieving a very high overall energy efficiency by (1) use of low-temperature environmental heat and heat from the co-composting process for drying sewage sludge thereby replacing high temperature heat from a combustion process, (2) a highly efficient gasification process, (3) saving of transport energy due to a better overall material flow management. Thus, the concept brings down disposal costs of sewage sludge. The polygeneration demonstration plant will be set up on an existing compost production facility. The latter will be able to process larger amounts of sewage sludge than at present, to produce less but higher quality compost as well as pellets and/or briquettes as storable substitute fuel and to deliver electricity to the grid. Heat will be used on site for drying processes and for a district heating grid of a neighbouring industrial park. CO2 emissions are reduced by replacement of fossil fuels and directly in the composting process. Minerals and nutrients will be recovered from the ash and used to enhance the fertilising value of the compost after removal of heavy metals and other harmful fractions. 5 out of the 8 consortium partners are SME. The exploitation plan includes the creation of a two further SME for heat delivery and worldwide planning and marketing o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unlocking the Croatian Textile Research Potentials' to be submitted under Seventh Framework.

assistant: **Abstract**

T-Pot aims to reinforce research potentials of Faculty of Textile Technology (TTF) in order to strengthen university sector to become one of the components of national innovation. The goals are to develop the capacity for breakthrough research leading to innovative textile and textile related products contributing in this way to local industry. Top scientists will be attracted to the country for exchange of know-how and guidance of Croatian textile manufacturers. Prerequisite for these objectives is an active participation in research projects and successful competing for funds in the European Research Area. For that reason T-Pot will reinforce human and material potential, so as research infrastructure. Three strategic partnerships with well established research institutions will be developed and further communication with other textile centres with similar scientific interest will be facilitated. Employment of 3 new PhD students, their training at 3 prestigious research institutions, so as acquisition of selected equipment will be significant contributions to the project goals. Dissemination activities such as organization of workshops, trainings, forums, round table and 2 conferences will contribute to spreading excellence and exploiting of project results and knowledge in particular within the industry. All stated activities will sustain the progress of real integration and cohesion of Croatian textile/clothing (T/C) sector into European Union Framework Programmes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High Speed Society, Slow Motion Democracy, and the Dilemma for Democratic Problem Solving' (SLOMODEMO).

assistant: **Concept**

Social acceleration – the progressively faster rate of technological, social, and life-pace change – has created a challenge for democratic problem solving. The demand for rapid and effective policy solutions is ever-increasing, while democratic politics often fails to keep up with urgent calls for intervention. We live in a high-speed society that is governed by a slow-motion democracy. This poses a fundamental dilemma for democratic problem solving: speed up decision making by circumventing democratic procedures, or hold on to slow procedures at the cost of effective problem solving. Either option could further erode public trust in liberal democracy, whose legitimacy relies on its ability to solve problems democratically and effectively.To address this challenge, SLOMODEMO advances a new theoretical and empirical research agenda to understand how and under what conditions social acceleration is negatively affecting liberal democracy’s capacity to legitimately solve problems. The project reconceptualizes liberal democracy as a problem-solving system, advances the theory and empirics of social acceleration, and offers cross-national and over-time studies of eight liberal democracies. This innovative approach enables key contributions on:- the measurement of the extent of social acceleration- social acceleration’s disruptive effects on liberal-democratic institutions and lawmaking- when and why citizens and politicians prioritize fast problem solving over democratic processes and the trade-offs they make- the strategies governments employ to cope with the dilemma for democratic problem solving and to what effectSLOMODEMO provides new theoretical and empirical knowledge and offers valuable insights for policymakers, institutions, and citizens alike, offering a path forwa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unique and overlapping functions and CNS sites of action for NK2R and LepR signaling' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Metabolic diseases such as obesity and diabetes rank among the primary causes of mortality worldwide. While new incretin-based drugs have made major inroads into the treatment of these diseases, issues with tolerance (including nausea, vomiting, diarrhea; and gastroparesis leading to delayed gastric emptying) threaten to limit the potential long-term compliance and impact of these medications. Thus, it is highly relevant to identify therapeutic targets that reduce appetite without activating aversive circuits or promoting gastroparesis. Recently, we discovered Neurokinin 2 Receptor (NK2R) as a new pharmacological target for treating obesity. When activated, NK2R improves energy homeostasis by reducing feeding and increasing energy expenditure, resulting in a decrease in body weight via diminished adiposity. Importantly, NK2R agonism controls appetite without activating CNS circuits that induce aversive effects and, unlike incretin-based therapies, can compensate for leptin-controlled feeding in leptin-deficient hyperphagic mice. This suggests that NK2R agonism mimics leptin for the control of feeding and likely engages leptin-regulated neural circuits. During this fellowship, I will define unique and overlapping functions and CNS sites of action for NK2R and Leptin Receptor signaling using proprietary pharmacological NK2R agonists, molecular genetic neuroscience techniques, metabolic phenotyping, and transcriptomics. This will not only expand our understanding of the promising mode-of-action of NK2R agonists but also has the potential to reveal new mechanisms of central homeostatic control that can be exploited pharmacologically for the treatment of cardiometabolic diseases. The combination of the expertise of my host labs and my experience will ensure the successful co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The poor healing ability of tendons, which play a critical role in the musculoskeletal system, as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. However, the limited knowledge on tendon development and healing processes has hindered the design of TE procedures that more closely recapitulate tendon morphogenesis. Extending beyond the state-of-the-art, MagTendon will explore conventional and innovative tools such as multimaterial 3 dimensional (3D) bioprinting to design magnetic responsive systems mimicking specific aspects of tendon tissue architecture, composition and biomechanical properties, which, combined with adequate stem cells, will render appropriate behavioural instructions to stimulate the regeneration of tendon tissue. Stem cell bioengineering approaches based on superparamagnetic nanoparticles (SPMNs), namely cell sorting, mechanoreceptors targeting and cell programming, will be used to unveil the cellular signalling pathways that trigger the tenogenic differentiation of the widely and easily obtained human adipose derived stem cells. Simultaneously, the 3D cell-laden magnetic system shall enable sophisticated 3D tissue models to unravel mechanisms behind tendon homeostasis and repair that will support the base knowledge to establish rational design criteria for the biofabrication of living tendon substitutes with the adequate signaling and structural cues to recapitulate tendon tissue developmental patterns. Therefore, the ground-breaking nature of the research proposed relies on the development of disruptive technological concepts for obtaining unique cell-laden 3D magnetically responsive systems that recapitulate key features of the native tissue and that can be f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Optimised expert system for conducting environmental assessment of urban road traffic' (OSCAR), addressing dissemination and exploitation.

assistant: **Impact**

This 3 yr project addresses the major problem of traffic congestion and air pollution (NOx, PM10, PM2.5), which diminishes the quality of life of the citizen and the environment. As European cities grow, road journeys and traffic congestion increase and PM10 and N0x often exceed European limit values. Current methods provide general solutions as they address smooth traffic flows and simple terrains, neither of which are applicable to major cities. Nor do they provide an integrated capability for identifying impact reduction options. OSCAR will not only result In new data (emissions and PMl0, 2.5) but also in new generation integrated traffic, emission and air pollution models for complex street geometries with hourly resolution. The optimised Expert System is based on latest advances but targeted at End Users to identify the most appropriate sustainable transport strategies to reduce urban road traffic and related pollution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Screening for plant factors that modify the function of the mammalian immune system'.

assistant: **Concept**

This project aims to discover protein inhibitors of complex biological processes and the characterization of their molecular targets. We plan to screen plant cDNA libraries for the presence of encoded proteins that inhibit or activate signal transduction pathways in mammalian immune system cells. This approach will be similar to classical mutagenic genetic screening or the recently popular chemical genetic screening for effectors of signal transduction pathways.The completion of the genome sequencing efforts for multiple species has recently resulted in a wealth of information that can be used in screens for novel polypeptide drugs. Complex plant genomes contain information that can be mined for inhibitors and activators of mammalian signal transduction pathways. Discovery of plant factors that interact with and modify mammalian signal transduction pathways will not only enhance our knowledge of how these pathways work, but also will be valuable for drug discovery. The discovery of plant factors that interact with mammalian signal transduction pathways will also enhance our knowledge of the signal transduction pathways in plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Improving the buildability of low power consumption boat hulls up to 50 M long'.

assistant: **Innovation**

An increasing number of small boats for passenger and workboat use are being built using 'flat-pack' methods where the individual hull sheets are designed using CAD and the output N/C data used to control the sheet cutting machines. With the drive to increase hull efficiency, ever more complex shapes are required and buildability" of these is increasingly difficult. This project sets out to develop a system of interlocking structures which can be incorporated into sheet designs which will hold the sheets in place during fabrication operations. These will be user-friendly and will allow substantial savings in time and skill requirements. The project will combine both mechanical engineering and mathematics departments of a university and the outcome will significantly improve the competitiveness of small boat and eventually medium sized building in Europe. "