RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'iINGUT: immunotherapy on an INtegrated GUt microbiome and Tumor on-chip.' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

In 2020, cancer affected 2.7 million people in the European Union and claimed 1.3 million lives, including more than 2,000 young adults. If immediate action is not taken, cancer cases are expected to increase by 24% by 2035. This project aims to accelerate the development of new cancer therapies. Immunotherapy, particularly through immune checkpoint inhibitors (ICIs), stands out as a highly promising treatment, utilizing the body's own immune system to target and destroy cancer cells with greater precision and fewer side effects than other approaches. Yet, the effectiveness of ICIs varies significantly between patients and tumor types. In this regard, the hosting laboratory has been on the frontline in studies that revealed the influence of the individual gut microbiome on the heterogeneity in ICIs response, opening new avenues for improving treatment outcomes.iINGUT (immunotherapy on an INtegrated GUt microbiome and Tumor on-chip) is a novel platform designed to study the modulatory role of the gut microbiome on the response of solid tumors to therapy, and in particular to ICI. iINGUT consists on a mechanically active microfluidic system integrating the complexity of multicellular structures and functions of the human intestine with a module dedicated to patient-derived tumor models. The entire platform can be personalized with fecal, blood, and tumor samples from the patient, providing a time- and cost-effective tool for predicting treatment outcome and developing novel immunotherapy-based strategies tailored for specific groups of patients. iINGUT will enable me to apply my engineering background to complex biological questions, facilitating my growth as a researcher and advancing my interdisciplinary expertise.


**Keywords:** microfluidics, immunotherapy, organ-on-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards increased biosafety for non-target insects - Damage-activated proteolysis to selectively enhance toxicity of pesticides' (DETOXPEST).

assistant: **Concept**

Insects numbers and diversity have rapidly declined in the EU and worldwide. Pesticides, and particularly the toxicity of insecticides to non-target insects (e.g. bees), are one of the major drivers of insect declines. Apart from destabilizing natural ecosystems, pollinator disappearance directly threatens food security.To help combat insect decline, I propose an innovative approach for the damage-activation of pro-pesticides (DAPP) by plant proteases that are activated in the gut of feeding caterpillars. Non-target beneficial insects that cause no damage, including pollinators and natural enemies of pests, are spared. My team pioneers the study of proteolysis in the plant wound response, following our recent discovery that physical damage activates a class of proteases, called metacaspases. I hypothesize that i) damage-activated plant proteolysis is a largely unrecognized but potential key player in the plant wound response to insect herbivores and ii) this knowledge can be used to enhance pesticide biosafety. We will study the impact of fall armyworm (Spodoptera frugiperda), an invasive insect pest and potential major threat to EU agriculture, on the model plant Arabidopsis thaliana and the economically important crop maize. A combination of advanced (N-terminomics) and novel (Proteome Integral Solubility Alteration) proteomics technologies will allow us to uncover unknown plant metacaspase substrates and damage-activated proteases and to assess their impact on insect herbivory. These fundamental studies will feed information into a pipeline of first-in-class DAPP development, where we will modify biological insecticides with newly-discovered protease cleavage sites. Finally, we will test toxicity against target (Spodoptera) and non-target insects. My early-stage and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'IN VItro Cavitation Through UltraSound' (INVICTUS) under Horizon 2020.

assistant: **Objectives**

Disorders of the central nervous system (CNS) contribute almost 800 billion euros in annual European healthcare costs. New compounds, effective in animal models, hardly work in humans, mostly due to the inability to cross the Brain Blood Barrier (BBB). In these conditions cost-effective tools to alter BBB and, more generally, endothelial layer permeability is desirable before proceeding to expensive and time-consuming animal studies. INVICTUS (IN VItro Cavitation Through UltraSound) originates within the ERC-AdG project Bubbles from Inception to Collapse (BIC) and concerns the development of a biomimetic micro-fluidic platform to be made turnkey available to biologists, clinicians and pharmacologists. The integrated platform exploits endothelial layer permeability enhancement by cavitation bubbles and provides an integrated, low cost platform to develop cavitation enhanced drug delivery under well controlled and reproducible conditions. Its potential is significant, given the well known societal and economical impact of degenerative diseases and the enormous investment and the long times of pre-clinical trials, as confirmed by a leading company operating in the field. Limiting/avoiding animal experimentation has an evident ethical impact and is associated with substantial economic savings and organisational simplification. In few words, micro-bubbles injected into the bloodstream undergo volume oscillations under localised ultrasound irradiation, with local reversible permeability enhancement of the endothelium. Already pursed in in vivo animal models, this approach is extended here to a high-fidelity, in vitro biomimetic device that will bring to market new crucial features such as the three-dimensional geometry of realistic-size vascular channels featuring an actual e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Settlement and spatial dynamics along the Appian way, between the Suburbium and the city of Rome' (SaSDAppia) targeting Seventh Framework.

assistant: **Abstract**

This research investigates the construction, the evolution and the development of  settlement spaces from the Republican to the Late Antique times in the area of the city of Rome, which is characterized by the extra-mural passage of the Appian way. It seeks to expand our knowledge of the critical area that delineates the passage between the urban and the suburban spaces of the ancient city. Its principal object is the contextual analysis of the suburban territory of the via Appia with the aim to reconstruct, in a diachronic way, the settlement dynamics that could attest the active spatial relationships between the urban and the suburban area. An important secondary goal is to define the functional zoning of this area and the changes in the use of places, outlining how historical artefacts can relate to new spatial programs. More generally, this is an investigation into the ways in which structures and places and their internal components were spatially organised. Within the study of spaces, the project explores the nexus of social, political and economic flows with the result of assessing the interaction and integration of the city and its hinterland. To achieve these goals, the project focuses on all ambiguous connections between the places that are located in the critical area between the urban and the suburban spaces. Among these places, an archaeological site will be chosen as a case study of the phenomenon: the systematic analysis of its spatial and social connections with the whole area and in a diachronic way will enable us to reconstruct the settlement dynamics of the territory through time. The project is thus based on two principal spatial domains of data: geographic, territorial or macro-scale data and monumental or micro-scale data. A holistic approach has b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Research and Innovation Centre on Advanced Industrial Production' to be submitted under Horizon 2020.

assistant: **Abstract**

The project RICAIP develops the fundamental for establishing the Research and Innovation Centre on Advanced Industrial Production by leading research organizations from the Czech Republic: Czech Institute of Informatics, Robotics and Cybernetics at Czech Technical University, and Central European Institute of Technology at Brno University of Technology, in strong partnership with prominent German research organizations: German Research Center for Artificial Intelligence and Center for Mechatronics and Automation Technology.The partnership will result in transferring knowledge and expertise from the German to Czech partners, as well as strategic long-term collaboration at all the levels of research, education, and innovation. This will guarantee the unique position of the Center within the European Research Area as a leader in the research field of advanced industrial production.The RICAIP Center will accommodate new areas of research and innovation in the field of Industry 4.0, namely multi-site production and production system development. The Centre will provide a distributed, but virtually integrated experimental testbed. It will be physically based on research facilities of the Czech partners, complemented by a corresponding remote site jointly operated by the German partners.The project’s ambition is to establish an international hub for Industry 4.0 bringing new smart, safe and sophisticated solutions for industrial multi-site production of the future. This project, however, goes beyond the state-of-the-art reference models of Industry 4.0 as it introduces a brand new dimension of the initiative - multi-site industrial production and production development, both with strong impact on society. The long-term vision is to transform the RICAIP testbed into a European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The eurosida network 2000-2004. clinical and virological outcome of european patients infected with hiv.' (1998-2002).

assistant: **Concept**

Despite recent improvement in prognosis of HIV-infected patients from across Europe due to use of powerful combination antiretroviral therapies, challenges persist-in relation to durability of responses and new co-morbidities. The primary objective of the Euros IDA study is to collect demographic, clinical, therapeutic and laboratory data on patients with HIV infection to determine the long-terminological and clinical outcome for patients from Europe. 10.900 patients from 63clinics in 20 European countries will be followed on a long-term basis (since1994), providing 40.500 person-years of follow-up. A plasma repository of 27.000samples will allow laboratory analyses related to HIV resistance and HIV,subtyping. The EuroSIDA main database will serve as a tool to study the course and evolution of chronic HIV infection in patients from across Europe in future. The partners have a proven record of highly productive collaboration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cytoskeletal force generation and force transduction of migrating leukocytes' under Seventh Framework.

assistant: **Concept**

Cell migration is a universal feature of all metazoan life and crucially involved in most developmental, homeostatic and pathological processes. Most efforts to understand its molecular and mechanical aspects were focused on the “haptokinetic” paradigm. Here cells generate traction by coupling the protrusive and contractile forces of the actomyosin cytoskeleton via transmembrane receptors to the extracellular environment. Our recent work demonstrated that leukocytes, the class of animal cells that migrates with highest speed and efficiency, violate this paradigm. Once embedded in physiological three-dimensional matrices they instantaneously shift between adhesive and non-adhesive modes to transduce force. This proposal suggests a combined cell biological and biophysical approach to elucidate the molecular and mechanical principles underlying such plasticity. We will focus on the machinery most proximate to force generation and use genetics and pharmacology to characterize how nucleation, elongation, depolymerization and crosslinking of actin filaments act in leukocytes migrating through environments of varying geometry and adhesive properties (Postdoc 1). Mechanical manipulations in conjunction with high resolution monitoring of substrate deformations will reveal how cytoskeletal force is transduced to the extracellular environment (Postdoc 2). In a technical support project (Technician) we will develop a cell-system with optimized access to stable genetic manipulations. Technically, these questions will be addressed by employing advanced live cell fluorescence imaging in combination with artificial environments engineered using microfluidics and substrate micropatterning. Importantly, findings will ultimately be challenged in living tissues. This multidisciplinary appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Jewellery Technology Network' in the context of a Fourth Framework call.

assistant: **Objectives**

The Project's main objectives are to develop synergies among European organizations, industries, research centres, academic organizations active in scientific and technological projects and training activities, involved in the European Jewellery Industry; to improve the exchange of information and knowledge among the different participants; to facilitate technology transfer to the low-tech end-users and accelerate the dissemination and exploitation of results from research activities through a coordinating action. The European Jewellery Industry is considered to be of a relatively low technical level. There is a serious lack of knowledge on specific materials, low awareness of quality in process technologies, and most Countries suffer from a low level of technical training. The majority of the European Jewellery Industry is based on conventional] technologies and not easily open to advanced technologies. This is mostly due to the dimension of production structures in this industry, formed mainly by micro-SMEs, without in-house research facilities and sometimes with a low level of managerial culture. Some European Jewellery industries - the largest ones and the most advanced and innovative SMEs - carry on their in-house research and training; and some Research Centres and Universities are working on materials (precious metals) and technologies. The European Jewellery Industry needs to be updated on the research projects closed and in progress and to be brought to a better and higher-level of technology through technology transfer from other industries. Dissemination of results deriving from these activities and training on latest technologies must be promoted and improved as well. The technologies developed will be transferred to both the industry and SMEs by the Network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A forward genetic screen in the marine planktonic diatom Pseudo-nitzschia multistriata'.

assistant: **Innovation**

Diatoms carry out 1/5 of the photosynthesis on Earth and are essential to aquatic ecosystems. In addition to their fundamental role in carbon fixation, they play a key role in the biogeochemical cycle of nitrate and silica, have other complex metabolic abilities (urea cycle, fatty acid metabolism) and developed several strategies for the adaptation to different, sometimes extreme, environments. An improved knowledge of diatom biology is crucial for understanding the basis of their ecological success, for predicting their capability to adapt to a rapidly changing environment, including climatic changes due to greenhouse gasses, and for industrial exploitation of their biological properties.The scope of this project is to generate a collection of stable mutants for diatoms through random chemical mutagenesis. Specifically, we want to isolate mutants with altered production of fatty acids, oxylipins and domoic acid, both to characterise the molecular pathways involved and to obtain clones of potential interest to industry. So far genomics and functional data are available for less than 10 of the 200.000 known species, we want to generate a tool that will facilitate molecular studies in these organisms. We have selected the species Pseudo-nitzschia multistriata for our studies because of its ecological relevance in Mediterranean ecosystems and because of its controllable life cycle with known sexual stages. As a preliminary step to this study we plan to exploit new sequencing technologies to sequence the genome of the selected diatom, this will allow to undertake positional cloning once mutants have been isolated and will represent per se a valuable resource. We will contribute to establish a Pseudo-nitzschia multistriata as a model organism and to develop molecular biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Towards new diagnostic standards - Development of a Protein Based Diagnostic Assay and of a Novel Anti-Abortion Drug Target (PIBF)'.

assistant: **Concept**

The proposed project is based on a family of international patents and other intellectual property owned by one of the consortium partners (BioDevelops). The patents claim the use of a natural protein with immunomodulatory activity as a diagnostic marker and as a drug candidate. The natural protein has been named "Progesterone Induced Blocking Factor" or PIBF. It has been shown by one of the consortium partners (Pro-Gestatione) that PIBF blocks the autoimmune response which normally leads to the killing of rapidly growing tissue, such as foetuses. High levels of PIBF are absolutely essential for the maintenance of normal pregnancy, therefore PIBF resembles a promising drug target. During the characterization of PIBF as an important mediator for the maintenance of pregnancy, it has surprisingly been shown that tumour cells also express PIBF, whereas no or low PIBF reactivity is found in the adjacent normal tissues. This indicates that PIBF constitutes an essential marker for tumour cells.The proposal describes the required steps to develop a novel testing assay to diagnose malignant tumours, to monitor tumour therapy and to diagnose premature abortion risk. The development of this diagnostic method is based on Development of a validated Enzyme Linked Immuno Sorbent Assay (ELISA), Research concerning the expression of PIBF in malignant tumours, Research concerning the expression of PIBF during normal and risk pregnancy For future development of PIBF as a novel drug target to support in vitro fertilization therapy it is envisioned to capitalise on the experience of one of the consortium partners (Intercell), a vaccine specialist.To achieve this goal it is required to Fully characterise PIBF via analytical testing in order to obtain GMP material for safety testing. The stra