RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Lymphatic Vessels in Inflammation and Cancer Metastasis' (LYVICAM).

assistant: **Innovation**

Primary cancers can induce lymphatic vessel growth (lymphangiogenesis), enhancing metastasis to draining lymph nodes (LNs). We found that tumors also induce lymphangiogenesis in draining LNs, leading to increased cancer spread to distal LNs and beyond. Very recently, we found that lymphatic vessel activation in peripheral tissues and draining LNs also plays a previously unanticipated role in the control of chronic inflammatory diseases. This proposal aims at a comprehensive characterization of the function of lymphatic vessels in inflammation, using a variety of genetic mouse models for enhanced or reduced lymphatic function, novel quantitative techniques for the in vivo imaging of lymphatic function, and a miniaturized 3-dimensional in vitro platform for the high-throughput phenotypic screening of libraries of small, drug-like molecules for modulators of lymphatic function. A genome-wide analysis of the gene expression profile shall be made from lymphatic vessels isolated by high-speed cell sorting and by immuno-laser capture microdissection from tumors and their lymph node metastases, inflamed tissue and its draining lymph nodes, and normal tissues, followed by functional characterization of potential therapeutic targets and diagnostic markers. Finally, we will establish novel genetically fluorescent mouse models for the in vivo real-time imaging of lymphatic activation, and we will develop an innovative approach for the in vivo detection of early micrometastases, using antibody-based PET and near-infrared imaging of tumor-induced stromal changes. These studies will improve our understanding of lymphatic involvement in inflammation and cancer metastasis, and will provide the basis for completely novel approaches to treat and detect inflammation and cancer metastasis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Healthy Textile' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The World Health Organisation has identified  that there are many textiles items used in hospitals being the main cause for Nosocomial infections (Hospital Acquired Infections-HAI). Nosocomial infections are one of a major global health concern being related with hospitals’ used textiles to be one of its primary causes. Nosocomial infections can result in prolonged hospital stays, long-term disability, and increased resistance of microorganisms to antimicrobials, therefore it presents massive additional costs for health systems, high costs for patients and their family, and unnecessary deaths. In Europe alone  every year about 5 million patients suffer from a Nosocomial infection out of which about 50,000 people may die, causing an annual financial burden of €7 Billion in direct costs. Healthy-Textile is a breakthrough powerful and permanent Zinc-oxide Antibacterial coating for Textiles based on the physical phenomena “Cavitation” - a High velocity implosion of voids/bubbles inside of a liquid solution, resulting in powerful micro jet-streams of over 500 meters/second which are impregnating the required chemistry molecules onto Textile fibers (“Sono-Coating”). Nano Textile’s technology is considered to be a game changer in the sense that for the first time in the world (patented), there is an effective Antibacterial coating for all Medical Textiles which is durable for Industrial washings, cost effective, and applicable to all Textile types. Healthy-Textile will prevent the spread of infectious diseases by eliminating bacteria, viruses and fungus, and even antibiotics resistant bacteria, and can transform any fabric into a protective shield against HAI for the patient. The patented technology permanently prevents the growth of bacteria on both natural and synthetic fabr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A NOVEL AND INTEGRATED APPROACH TO INCREASE MULTIPLE AND COMBINED STRESS TOLERANCE IN PLANTS USING TOMATO AS A MODEL' (TomRes).

assistant: **Innovation**

Tomato is a main EU agricultural commodity, cultivated all over Europe in open and protected field and in glasshouses, representing a biological and agronomical model crop. Combined water and nutrient stress is a major problem for tomato farmers and solutions are needed to safeguard yields, while preserving the environment.TOMRES will select, among over 10,000 available accessions, rootstocks and scions tolerating combined stress, while retaining fruit quality and yield, taking advantage of innovative screening approaches. Novel traits, in particular belowground, to be exploited in breeding, will be identified. The role of selected hormones (strigolactones and brassinosteroids) will be studied to identify further resilience traits. TOMRES will test and optimize sustainable crop management strategies such as legume intercropping, precision fertilization and irrigation techniques, manipulation of symbiotic microorganisms, and the use of rootstocks more suited to water and nutrient uptake from the soil. Novel genotypes X management strategies will be developed with the goal of reducing N and P application by at least 20%, water input by 40%, while granting environmental sustainability and economic viability of the solutions proposed.Testing will be integrated with analysis of environmental (greenhouse emissions, water quality), and of socio-economic impact. Agronomical, environmental, and economical data will be processed to construction of models and of a Decision Support System. Demonstration and dissemination activities will follow the whole course of the project, and will transfer the results to different environments and other cropping systems, thus ensuring the widest impact of the gained knowledge on the EU economy. Trans-disciplinary knowledge transfer among farmer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Technological change at the South-western limits of the Mediterranean basin during Neolithic and early Chalcolithic times: pottery production and consumption' to be submitted under Horizon 2020.

assistant: **Abstract**

This project examines the radical social changes which took place in the South-western Mediterranean basin during the Neolithic and the beginning of the Chalcolithic period, and specifically the interactions between North Africa and the southern coast of the Iberian Peninsula across the Straits of Gibraltar. It takes an explicit technological approach informed by Material Culture Studies which uses the reconstruction of the craft of pottery manufacture to inform our understanding of social transformation.It comprises the first research programme focused in pottery analysis across a wide area of study, including North African and European production, the first of which remains mostly unknown until now.The methodology employed is an integrated approach based on instrumental analysis of pots (optical petrography and SEM), including morphological, ornamental and functional characterization of ceramic products; as well as the comparison of ceramic fabrics with potential raw materials in the study areas.A number of key archaeological questions are addressed in this way. The time period considered sees changes in food production, along with increased sedentism and specialization in craft production of ornaments. While Neolithic cultures have often been defined according to their pottery and their stylistic groups, it is the technological traditions associated to them will allow us to explore mechanisms of knowledge transmission and innovation, labour organization and the construction of exchange networks. These are all key aspects which allow us to explore the links between technological change and the social change in the human communities in the area in study, at a time when semi-nomadic groups adapt to sedentary ways of life with the emergence of social asymmetry and labour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Full-scale demonstration of a flexible inline production concept for breweries, drawing on water hydraulics' to be submitted under Horizon 2020.

assistant: **Abstract**

The brewing industry is a strong pillar of the European economy with more than 2.3 million jobs linked with this industry. Today it is facing unprecedented challenges as the competition increases and the consumers are more demanding than ever. To remain competitive, breweries need to invest in solutions that may increase their productivity, cut costs and adapt quickly to what the market desire. HYDRACTFLEX vision is to introduce a new production paradigm concept – Flex Supply – that will enable for the first time integrated: High Gravity brewing, Just-In-Time production and inline mixing of beers, directly from the bright beer tanks, increasing productivity and decreasing costs for the end-user. HYDRACTFLEX will leverage a technological synergy between complementary innovations of technology providers (water-based actuators/valves (KMR), control software (ProLeiT) and monitoring sensors (ACM)) to offer a full package capable of regulate/control the new process with unprecedented precision, which is indispensable to unlock the full potential of Flex Supply. The overall aim is to mature and prove full functionality and benefits of the integration of the three core technologies that together will enable the Flex Supply concept, in the context of a full-scale demonstration, at Carlsberg (Fredericia, DK). The full-scale demonstration will overcome the remaining market barriers, while prove: reductions in costs, materials usage, energy demand, CO2 footprint, product losses; increases in flexibility and productivity; and enhanced beverage safety. HYDRACTFLEX will have a significant impact on the partners competitiveness and visibility. The partnering with a leading player is already a tremendous validation of the potential of our solutions and will be the definitive leverage f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced Security Service cERTificate for SOA', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The term certification" has several different meanings in ICT. Software practitioners can earn a certificate for expertise in a certain hardware or software technology. The maturity of crucial IT processes, such as software development, can be and is often certified. Even individual software systems can be certified as having particular non-functional properties, including safety, security or privacy. However, the latter type of certification (e.g. Common Criteria) has had only a limited use to this day. Current trends in the IT industry suggest that software systems in the future will be very different from their counterparts today, due to greater adoption of Service-Oriented Architectures (SOAs) and the wider spread of the deployment of Software-as-a-Service (SaaS). These trends point to large-scale, heterogeneous ICT infrastructures hosting applications that are dynamically built from loosely-coupled, well-separated services, where key non-functional properties like security, privacy, and reliability will be of increased and critical importance. In such scenarios, certifying software properties will be crucial. Current certification schemes, however, are either insufficient in addressing the needs of such scenarios or not applicable at all and thus, they cannot be used to support and automate run-time security assessment. As a result, today's certification schemes simply do not provide, from an end-user perspective, a reliable way to assess the trustworthiness of a composite applications in the context where (and at the time when) it will be actually executed.ASSERT4SOA will fill this gap by producing novel techniques and tools –  fully integrated within the SOA lifecycle – for expressing, assessing and certifying security properties for complex service-oriented appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanotaxis in the guidance of cancer metastasis' (MGCM), addressing dissemination and exploitation.

assistant: **Impact**

Cell migration is a critical event in many physiological processes, such as embryogenesis, inflammation, and tissue regeneration, as well as malignant states, such as cancer metastasis. Cells migrate in response to gradients of chemical factors (chemotaxis ), gravitational forces (geotaxis), and electrostatic potentials (galvanotaxis). Recently, cells were found to directionally migrate also in response to gradients of substrate rigidity (mechanotaxis). Thus far, cell types that are exposed to or depend on constant fluctuations of the mechanical properties of their microenvironment, such as osteoclasts, smooth muscle cells, and endothelial cells, exhibit mechanotaxis. Increased rigidity is a strong characteristic of solid tumours. Invasive cancer cells are subject to alterations in the mechanical properties of the primary tumour microenvironment they originate from, as well as the tissue where they metastasize. Nonetheless, mechanotaxis and its controlling mechanisms have barely been studied for cancer cells.The goals of the proposed project are to:a) determine whether various human cancer cell lines, initially, and primary cancer cells, subsequently, of varying invasiveness exhibit mechanotaxis on two and three dimensional substrates of different rigidities;b) investigate the intracellular signalling pathways directing mechanotaxis in metastatic cancer cells; andc) study cancer cell migration in response to parallel or opposing gradients of both mechanical (mechanotaxis) and chemical (chemotaxis) stimuli.Collaboration with scientists from other disciplines (biomathematics and physics) will enable the compilation of the biological results into mathematical models that can be employed in the prediction of the course of metastasis. The gained knowledge from this project w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Ultra compact high flux gaas cell photovoltaic concentrator'.

assistant: **Innovation**

The objective of the project is to combine existing industrial technologies and optimise them in a PV concentrator device which has the economic potential to produce bulk electrical power at the low cost required to justify its integration in a utility grid in Southern Europe (Spain, Italy, Portugal, Greece, South of France). The existing industrial technologies to be assembled and optimised are the following: (a) A concentrator providing 1000 suns on the solar cell whilst still allowing an angular acceptance of + 1,5 degrees to produce more than 95% of the maximum power. This later feature has never been used before in a PV system. (b) Liquid Phase Epitaxy GaAs cells developed by a cheap technology similar to the one used in European optoelectronic industry. Also GaAs cells deriving from recent industrialisation in Europe of thin space solar cells by MOCVD epitaxy. Two substrate options will be evaluated: GaAs and germanium. (c) Bonding and packaging technology already developed for common optoelectronic commercial devices (LED's, photodiodes, etc.) which are of similar dimensions to the GaAs solar cells envisaged. The technological targets to be achieved by the concentrator device are the following: (a) Conversion efficiency range 20-22% (@ Tcell=25 C); (b) GaAs cell efficiency 24-26% (@ 1000 suns and Tcell=25 C) with a cell diameter in the range 0.5-2 mm, (c) optical efficiency greater than 85%, (d)concentrator aperture 18-70 mm, (e)total concentrator thickness from 0.3 to 0.4 times the concentrator aperture diameter, (f) an angular acceptance not smaller than + 1.5 degrees between incidence angl for which the output power is 95% of the maximum power, and + 2.5 degrees for 5 (of power), and (g) a heat sink producing a cell temperature not greater than 40ºC above the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Interactions between soluble factors and NCAM isoforms and role of the carbohydrate PolySialicAcid (PSA) in the control of axonal growth and guidance.' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The immunoglobulin super family adhesion molecule NCAM is implicated in cell migration, axonal outgrowth, and synaptic plasticity under normal or pathological situations. Recently, NCAM was demonstrated to physically interact with the growth factor GDNF a soluble factor also active in modulating axonal migration.   In my research project, I will examine: the mechanisms by which GDNF interacts with NCAM and how PSA, the polysialic posttranslational modification of NCAM, is able to regulate NCAM activity. For this purpose, I will develop two approaches:  1. I will observe the localization, trafficking and recycling of NCAM isoforms, NCAM140 and NCAM180, during neuronal development and cell migration and I will investigate the effect of GDNF on NCAM movements and relocalization. I will observe the two NCAM isoforms, NCAM140 and NCAM180 simultaneously and test whether their dynamic is specific, and if they respond differently to GDNF.  2. I will also observe whether PSA is capable of regulating the NCAM dynamics, and I will study the effects of this posttranslational modification on the binding of NCAM to several known interacting proteins. I will also focused on the lipid raft and determine whereas these microdomains enriched in potent effectors of signal transduction are essential for the physical interaction of NCAM to GFR and GDNF and therefore for the signalling initiated by this interaction.   For this work, I will use culture of dissociated neurons, from NCAM- or PSA-deficient or GFP-NCAM mice. Cell imaging technologies such as time-lapse and FRET system will be used to monitor the proteins in living neurons. In addition biochemical approaches will help to identify the PSA-dependent NCAM-interacting proteins. A long-term interest will be to understand how these molec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'HYdro-POwer-Suite' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Hydropower as the world’s largest source of renewable energy still has a high unused potential to be explored in times of a changing global energy policy. The economic and ecological evaluation of new hydropower developments rely on a number of environmental conditions, such as key hydrological parameters. For example, the major drivers of the reservoir storage capacity over time, reservoir life time, and also a major driver of the operations costs are directly related to the sediment regime and sediment trapping. HYPOS is catalyzing innovation with an operational service for appropriate environmental and economic investment planning and monitoring based on Earth Observation (EO) technologies and modelling for the Hydropower industry.The to developed online accessible Decision Support Tool will provide essential assets for hydro power managers, planners and decision makers in their work. The subscription portal brings together high-quality satellite based measurements for historic time periods, actual current monitoring, up-to-date modelled hydrological parameters, with nowcasting on various orderable levels of detail and available in-situ data for integrated baseline and environmental impact assessments.The service significantly contributes on a trans-national as well as a global scale, with the requirement of independent, standardized and consistent information over a wide range of different water bodies and spatial scales. Substantial Blue Footprint analysis are enabled based on sophisticated and state-of-the-art algorithms and methodology featuring sustainable long-term monitoring solutions.