RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Interdisciplinary Modelling of Climate Change in Coastal Western Antarctica - Network for Staff Exchange and Training'.

assistant: **Objectives**

The proposed European-US and South American network IMCONet will advance climate and (eco-) system change research at the Western Antarctic Peninsula (WAP), a region of recent rapid aerial warming. WAP glaciers contribute to global sea level rise, and functioning and services of coastal ecosystems are massively threatened by the fast regional warming. Data sets from recent interdisciplinary European-South American field work within ESF-IMCOAST (PolarCLIMATE April 2010-March 2013) and from the Jubany scientific core programme at King George Island (KGI) will be connected and cross-validated with southern stations on WAP: the US Palmer and the British Rothera station. Links with both stations and program leaders (Ducklow, CU, New York, US (formerly at MBL Woods Hole,US); and Meredith, NERC-BAS, Cambridge, UK) have been established in IMCOAST. IMCONet objectives are A) to develop predictive climate change and ecosystem models for the whole WAP coastal environment based on existing data sets and data exchange policies, B) transfer of knowledge between partner countries to enhance collaboration with high quality long-term measuring programs at all 3 stations, to fill present measuring gaps. This will solidify the basis for the prediction of climate change effects in the South. The proposed consortium consists of 16 institutional partners across 10 countries with 85 travelling scientists. Ten partners already collaborate successfully as EU and associated teams in ESF-IMCOAST, and IMCONet will be coordinated by the same PI (Abele, AWI). Whereas ESRs are seconded mostly for longer training and collaboration periods, exchange of ERs will also foster joint teaching in the partner countries and collaboration in future science projects. The concept of IMCONet is to strengthen Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of oral fixed-dose Artesumate-based combinations for the treatment of uncomplicated malaria' under Fifth Framework.

assistant: **Concept**

This proposal aims at the fast-track pharmaceutical development and clinical validation of two artesunate-based fixed-dose combinations for the treatment of malaria, including the preparation of relevant registration files. The goal is to make these new combination drugs available for use as quality, safe, viable, adapted and affordable drugs in the endemic countries. This project constitutes a missing link in promoting antimalarial policy changes towards combination therapy, and the successful implementation thereof. It builds upon the expertises of R& D centres in the EU and different regions in the South, which are being mobilised in an international effort to dramatically improve the available malaria treatment tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Intelligent Robotic Porter System' (IRPS).

assistant: **Innovation**

The purpose of the project is to provide mobile robotics platforms with advanced mapping and navigation systems based on a very accurate positioning and 3D measurement technology. This concept will be developed and implemented as a key component for robotic applications for quality and dimensional control, ambience monitoring inspection and advanced navigation. Applications will be deployed for operation in large areas and within congested human environments. Operation within a network of co-operative robots will be considered. The 3D measurement technology, named LIMS (LIDAR Imaging and Measurement System) is based on an innovative concept of real time measurement of position in presence of sparse regular objects. The measurement technology principles based on three eye-safe laser systems were originated in IAI-Lahav and are patent pending. The main objective of the project is to develop and integrate an accurate 3D sensing system as a modular component for robotics platforms, enabling fast dense mapping of large areas, populated with sparse objects. The project will demonstrate its application and integration as modular positioning and measurement component (LIMS). When integrated in mobile platforms this component will allow mapping large areas, in real time and reasonable speed (5m/s).During the project, and due the map accuracy, the LIMS will be used to recover the position of the robot related to the environment by using natural landmarks, through the comparison of the actual 3D map with previous 3D maps already stored. This operation will be complemented with reflectance and video data to increase information and robustness. Since the positioning and mapping will not rely on absolute positioning systems, the application can be used indoors as well as outdoors env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Neutral Quasi-Particles in Mesoscopic Physics'.

assistant: **Objectives**

I propose to study ‘neutral excitations’ in 2d and 1d electronic systems.  Such excitations, rarely studied, are unique since they are chargeless but may carry energy.  Being byproducts of electron interaction, they come in a few flavors:  (i) Downstream modes in composite edge channels of the integer quantum Hall effect (IQHE) regime; (ii) Upstream modes in the fractional quantum Hall effect (FQHE) regime; and (iii) Zero energy Majorana states (localized or propagating quasi-particles), in non-abelian FQHE states and in 1d topological P-wave superconductors.  My main interests in neutral modes in the QHE regime are: (a) Their direct association with the nature of the wavefunction of the quantum state; (b) Being excited when a charge mode is being partitioned (say, by a quantum point contact), they may play a prime role in dephasing interference of quasi-particles due to the energy they rob (in the partitioning process).  As for detecting Majorana quasi-particles, and aside from the exciting physics, their non-abelian nature makes them attractive as building blocks in ‘decoherence resistant’ systems.  Based on our acquired  abilities, such as material growth, processing techniques, and sensitive measurement techniques, I plan to perform experiments, which include: thorough studies of downstream and upstream neutral modes via shot noise and thermoelectric current measurements; proving (or disproving) their involvement in dephasing fractionally charged quasi-particles; growing and processing structures that harbor Majorana states (in 1d nano-wires and in 2d FQHE regime; and, possibly, eventually, manipulate Majorana states (by coupling and braiding).  Experiments will employ, e.g., ultra-low temperatures, sensitive shot noise measurements, cross-correlation of current flu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Modifying Enzyme with Solid-Binding Peptide for Site-specific and Reversible Enzyme Immobilization'.

assistant: **Innovation**

Redox enzymes catalyze numerous biological processes that are also relevant for a variety of applications, including energy conversion, biosensing, and electrosynthesis of complex molecules. The intrinsic lability of enzymes that gradually lose catalytic activity over time, however, restricts their operational half-life for practical large-scale application of this sustainable and incredibly energy-saving system. Moreover, enzymes are nanometer-sized macromolecules, that must be properly aligned with the electrode surface for efficient electron transfer and substrate access to the active site regardless of the electron transfer mechanism, direct or mediated, which typically necessitates laborious procedures. The goal of this Marie Skłodowska-Curie Postdoctoral Fellowship project is to develop a reversible immobilization approach that can attach enzymes on an electrode surface in a defined orientation and permit their controlled release on demand upon stimulation (ReversE). This will be accomplished by capitalizing on a gold (Au)-binding peptide fused to [FeFe]-hydrogenase as the model enzyme to have the dual functionality of orienting enzymes on the Au electrode surface in a precise manner to support efficient electron transfer and substrate access to the active site, as well as allowing the bound Au-binding peptide fused enzymes to be released by electrochemical or chemical stimuli and replaced with fresh enzymes when the catalytic activity is reduced to a predetermined value. This will open up the possibility for enzyme regeneration which will be groundbreaking in the context of sustainable deployment of enzyme‒electrode systems.


**Keywords:** Enzyme immobilization, Protein engineering, Bioelectrocatalysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimal annual routines of non-migratory birds: the effects of state' (2002-2006) under Sixth Framework.

assistant: **Objectives**

In a periodically changing environment it is important for animals to time the major events of their life (breeding and moult) in order to maximise their lifetime fitness i.e. they should optimise their annual routines. Our understanding of what ecological , evolutionary or life history factors are responsible for the evolution and maintenance of the considerable variability in annual schedules between populations and species is still unsatisfactory.The understanding of these factors is, however, important. First, it may provide the missing link between individual behaviour and population-level processes resulting in models that are more useful for nature conservation. Second, by clarifying the interactions between state variables (e.g. feather quality, health status) and annual routines it may serve as the basis to implement new methods in which measuring state variables can be a convenient way to estimate parameters of population processes. The proposed research focuses on how state variables influence future behaviour of birds and, vice versa, how variation in annual routines changes state variables. To do so, we first develop a new class of models based on the recent theoretical approach to optimal annual routines and we then test the predictions of these models using field observations and experiments to investigate the interactions between feather quality, health status, timing of breeding and moult.As the result we will understand how various factors influence the timing of breeding and moult and how individual behaviour might affect population processes. The project contributes to the objectives of the Specific Programme as follows. I can continue my work in my homeland allowing the transfer of the knowledge I gained during my Marie Curie Fellowship. It promotes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dynamic and evolution of cis-regulatory elements involved in fruit development in Arabidopsis and Brassica' (DEHICIS) targeting Seventh Framework.

assistant: **Abstract**

Despite the growing number of transcription factors that play a role in fruit patterning in Arabidopsis, little is known about the molecular interactions that control this fundamental process for plant reproduction. The proposed project focuses on genes and interactions that are relevant for fruit dehiscence. One of these key genes is REPLUMLESS (RPL) which is required for the development of a specialized structure, the replum, involved in the opening process of the fruit to release seeds. RPL functions in part by restricting the expression of SHATTERPROOF (SHP1 and 2), which specify valve margins (another specialized tissue type that surrounds the replum), and JAGGED (JAG), which promotes SHP gene expression. Although closely related, Brassica and Arabidopsis fruits show differences in replum development. Whereas the Arabidopsis replum is about 10 cell files wide, Brassica replum often only consists of 1-2 cell files. This phenotype mimics the phenotype of a weak rpl mutant in Arabidopsis , therefore a further reduction of the replum size in Brassica could give rise to shatter-resistant fruit that would benefit the oilseed rape industry. Our broad goals are to understand whether regulatory changes in RPL, JAG and SHP explain differences in fruit development between Arabidopsis and Brassica, and how further changes could be used to limit pod-shattering in Brassica. We will compare the regulatory sequences of these genes in different species, define cis-elements that mediate the interactions within this regulatory network, test the functional significance of these cis-elements in transgenic plants, then use TILLING to screen for regulatory changes in Brassica. Bridging our knowledge from Arabidopsis to Brassica would give us a great opportunity to study how variations in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced solar volumetric air receiver for commercial solar tower power plants ('SOLAIR')' (SOLAIR).

assistant: **Concept**

Objectives and problems to be solved: The EU policy is firmly supporting the development of renewable energies as one measure to reduce greenhouse gas emissions, with a target to double the share of renewable in the EU energy balance by the year 2010. Solar thermal power plants in Mediterranean countries present an excellent option to contribute to this goal at competitive CO2- avoidance costs. Europe's first solar thermal tower power plant to be operated on a commercial basis is being planned in southern Spain. This 10 MWe system based on a metallic volumetric air receiver, will take a conservative design approach to minimise technical and financial risks. It is the objective of this project to develop and demonstrate a new volumetric air receiver technology which is based on ceramic volumetric absorber modules, resulting in improved reliability and performance with reduced component costs for the next generation of solar tower power plants. Description of work: The project consists of two consecutive phases. During the first phase, the design, manufacturing, treatment and assembly of the ceramic absorber modules will be optimised according to specified cost and performance requirements. The absorber module will be qualified in small-scale pre-tests. Steel structure supporting the absorber, warm air return system and passive control elements to homogenise the outlet air temperature will be developed. The qualified components will be assembled and tested at the 200 kith receiver test bed at the Platform Solar de Algeria. Material investigations on absorber material degradation will be performed with the exposed elements in order to estimate lifetime expectations of these new elements. The second phase will provide the necessary intermediate step in the scale-up to a lar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Treatment of EGFR over-expressing cancers by targeted non-viral delivery of PolyIC' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

We have recently shown that application of EGFR targeted synthetic dsRNA: Poly Iosine/Poly Cytosine (pIC) is highly efficient and selective against deadly cancers overexpressing EGFR, like glioblastoma (U87MGwtEGFR), breast cancer (MDA-MB-468) and adenocarcinoma (A431). Double-stranded RNA, frequently expressed in cells infected with viruses, activates a number of pro-apoptotic processes simultaneously. These dsRNA-induced mechanisms efficiently kill infected cells and induce expression of anti-proliferative cytokines from the interferon (IFN) family, thereby preventing spread of the virus. pIC delivered with Melittin-polyethylenimine-polyethyleneglycol-EGF (MPPE) eliminated orthotropic and subcutaneous tumors of the above cancers. Heterogeneous glioblastoma models where only half of the cells overexpress wtEGFR are also eliminated by local application, most likely due to a bystander antiproliferative effects, at least partially mediated by interferons (Shir et al., 2006). Systemic application of EGFR targeted pIC is also highly effective against breast and adenocarcinoma disseminated cancer models resembling metastatic cancers (Shir et al., 2011).  During the last two years we have improved the vectors homing to EGFR to entities that can now be translated into clinical agents (Shaffert, 2011; Shir 2011, Abourbeh 2012). The impressive results with these more simplified vectors, make this project ready for clinical development, which requires fund raising from a Company/Venture capitalist. Commercialization of the therapy will be detailed in the proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Socio-Economic Research and Geographic Information Systems' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The proposed two conferences develop further the themes of the existing Euroconference series on Socio-Economic Research and GIS. This series included a successful conference at Il Ciocco, Italy, in May 1997 on the Socio-Economic Impacts of Geographic Information Handling Technologies, and one at Espinho, Portugal, in May 1999 on the Socio- Economic Analysis of Geographic Information. The theme of the first conference proposed in this application is the Digital City. It will focus on the developments in representation technologies (VR, spatial multimedia), and the creation of the spatial data infrastructures that are required to support the analysis and management of urban environments, as well as the requirements to support more effective urban management and greater public participation. The theme of the second conference proposed is Geographic Information for Health and the Environment.It focuses on the opportunities created by geographic information to link health events to the social and physical environment in which they take place, thus yielding deeper research insights and enabling more effective needs assessment and targeting of service provision. Both proposed conferences build upon activities and networks promoted by the European Science Foundation, such as the GISDATA scientific programme (1993-97), and the new programme on Social Variations in Health for the period 1999- 2001. They also link to key research priorities identified in the thematic programmes of the Fifth Framework Programme. The key objectives of the series is to promote greater awareness of the opportunities and limitations created by digital geographic information and related technologies for social science research, promote inter-disciplinary dialogue, and exchange of experience between sen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Rotorcraft handling, interactions and loads prediction (RHILP)'.

assistant: **Concept**

The RHILP project will investigate phenomena at low speed and provide aerodynamic models for Handling Qualities prediction and Flight Control System (FCS) design of Tilt-Rotors (T/R). The main objective is to limit risks related to T/R handling characteristics. Other objectives are to assess the risk of exceeding structural loads during manoeuvres and to define control features to prevent this risk. It is proposed to define relevant Handling Qualities criteria for T/Rs, to evidence control-critical and load-critical aspects of T/R flight, to define control solutions for load alleviation and stability augmentation. This will contribute to prepare the development of a future European T/R demonstrator by setting specifications for its FCS. The RHILP project will also bring a significant improvement in the European knowledge about rotor/airframe/ground interactions at low speed that could also profit to the safety of conventional helicopters.