RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Peptide ligands with restricted mobility through a Suzuki reaction: design, synthesis and evaluation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of this research proposal is the application of the Suzuki-Miyaura reaction to the synthesis of peptidic libraries with restricted mobility. Specifically, we envision the synthesis of a family of cyclic peptides that will contain a biaryl bond, to further restrain their conformation. This biaryl bond will be obtained through a Suzuki-Miyaura set of reactions between two aromatic amino acid derivatives in the sequence. Initially, the reaction conditions will be optimized on simple models: the order in which the bicyclic peptides should be assembled, solid vs. solution-phase, Suzuki-Miyaura reaction conditions…Once the synthesis has been optimized, several peptide libraries will be prepared, progressively increasing the synthetic challenge and including D- and non-proteinogenic amino acids. The ultimate goal of the project is to obtain new series of peptides which will act as ligands of certain protein surfaces (POP, DPP-IV and VEGF), for which they will have been designed. The sequences to be synthesized will be first decided on rational design basis assisted through evolutionary algorithms and, later, based on the results obtained for the interaction with the therapeutic target. Special attention will be placed on the conformational study of such constrained molecules. The interaction of the new peptides with the proteins surfaces, as well as their ADME properties will be evaluated through different methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Flexible Application of Uncertainty for Scanning and Tracking'.

assistant: **Objectives**

F.A.U.S.T. -- ""Flexible Application of Uncertainty for Scanning and Tracking"" proposes to integrate uncertainty information about medical image processing methods completely into the clinical work flow. This requires to solve computational problems that arise when different algorithms try to monopolize the available hardware. These problems becomes even more demanding for algorithms that are accelerated by Graphics Processing Units (GPUs). To overcome the current shortcomings of recent programming methods for GPUs, the fellow will use a novel GPU-accelerated framework, which he has developed during his previous career together with his colleagues form Graz University of Technology as a base. During the proposed project, the fellow will first adapt this framework to make scheduled and prioritized execution of GPU-accelerated medical segmentation and registration algorithms feasible, subsequently apply and evaluate this framework for existing algorithms and further develop a concurrent real-time visualization of uncertainties, which are currently neglected during medical standard procedures. To proof the flexibility and applicability of the proposed methods, the fellow will finally develop a novel Magnetic Resonance Imaging (MRI) scanner steering method, which is based on uncertainty information and which will allow to evaluate the organs of a moving foetus within the uterus. In contrast to Ultrasound-based imaging, the proposed new method will allow  an earlier and more accurate diagnosis of malformations and foetal diseases and will enable treatments in time. Thereby, the fellow will draw on his rich experience with GPU accelerated three-dimensional and four-dimensional medical volume processing and will provide unseen interactive results in the course of F.A.U.S.T.."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Patterned microfluidic sheets for studies of root exudation profiles', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Modern plant varieties have been bred to grow and increase production under non limiting soil conditions and have consequently lost their ability to capture resources efficiently. Designing an efficient fertiliser requires optimising bioavailability and mobility of nutrients. Unfortunately, bio-availability and mobility are often antagonistic. Traditional fertilisers, which package soluble mineral elements into granules, are easily acquired by plant roots but have been linked to excessive loss to the environment and pollution. Slow release fertilisation has been proposed to slow down the diffusion of nutrients to the soil, including the use of nanotechnology, but slowing down the diffusion of nutrients excessively affects root uptake. Biological fertilisation is inspired from known mechanisms observed in soil, but maintaining efficient colonisation of the root by beneficial microbes is challenging. New approaches must be developed to better control the associations taking place between plants and beneficial microbes, since fundamental knowledge to achieve this target is nowadays lacking. Roots exude a huge diversity of biomolecules, and their role in maintaining adequate beneficial microbes are mostly unknown and rarely studied. The aim of the RhizoSheet project is to apply cutting-edge microfluidic techniques based on hybrid paper-polymer technology for device fabrication. Optical sensors and novel functional materials will be applied as biochemical sensors to gain knowledge on the location of compounds secreted by roots and on the response of roots over time, when interacting with soil microbes.The acquired knowledge will be highly beneficial for the scientific and agricultural community and finds the interest of the EU in soil and food safety, the RhizoSheet project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Management of high risk opiate addicts in europe - risk opiate addicts study - europe (ROSE_EU)'.

assistant: **Objectives**

Background of this study is that in spite of the big range of therapeutic options for opiate addicts, there are major deficiencies in effective recruitment for treatment and treatment effectiveness. An important group of opiate addicts is not reached by therapeutic services and many of them are exposed to comparatively high risks. Furthermore many addicts in treatment drop out prematurely. Additionally many addicts in maintenance treatment continue to use illicit drugs. Treatment strategies for this group of patients are not uniform or systematically evaluated within Europe. The studies aim is to analyse these problems and to evaluate treatment programmes to meet the needs of high-risk addicts with the goal of developing recommendations as well as guidelines for standards in management of these high-risk addicts. For this, an extensive empirical stocktaking will be carried out in 5 European cities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Improving the safety of blood and organ supply by creating the research infrastructure to monitor emerging pathogens and develop new screening tests'.

assistant: **Objectives**

In Western Europe, blood and organ safety is not guaranteed for several reasons:- Emerging novel infectious agents and mutating known viruses remain a permanent threat;- Currently, it takes many years to assess the clinical relevance of new/mutated pathogens and to take appropriate measures;- Appropriate and cost-effective screening procedures (e.g. not all blood-borne viruses are screened for, viruses mutate and may escape detection) are not fully available;- 30-40% of recipients are immunodeficient and at considerably higher risk of infection and of pathogenic consequences than those immunocompetent.However, this higher level of risk has not been addressed adequately and specific safety measures to reduce it remain to be defined. BOTIA aims to improve safety of blood transfusion/ organ transplantation by:- The creation of an infrastructure consisting of an EU-wide sample repository of paired donor and recipient samples that will enable fast assessment of emerging blood borne agents such that appropriate measures can be taken without delay. This repository will also be a valuable tool for studying new safety aspects of already known viruses in relation to immunodeficiency and for carrying out retrospective studies once new viruses are identified after completing the BOTIA project;- The identification of novel/mutated blood and organ borne viruses by applying a PCR-based assay, enabling detection of viral DNA or RNA without a priori knowledge about the agent genome;- The improvement of donor screening in a number of ways:a) identifying limitations in current screening procedures;b) developing more cost-effective and safer screening procedures for EU countries (multiplex screening assays),c) developing inexpensive and simple test procedures for newly discovered viruses f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Gas Phase Structural Dynamics Imaging' (GPSDI) targeting Seventh Framework.

assistant: **Abstract**

Chemical reaction mechanisms are at the core of fundamental science questions (like the functionality of biological molecules), as well as important technological advances (like the development of new materials). Understanding reaction mechanisms with atomic detail promotes both basic understanding of natural phenomena and knowledge-based technological applications. Despite the giant steps in the last decades in understanding chemical reactivity and achieving more control over chemical reactions at the atomic level, current knowledge comes mainly from spectroscopic and dynamics techniques which probe only a small fraction of the potential energy surface.We propose a different approach: to use Ultrafast Electron Diffraction (UED) to study chemical, physical and biological phenomena by imaging the structure of the intermediates involved as a function of time, all the way from reactants to products. In UED, a short laser pulse triggers the dynamics and diffraction of a short burst of electrons probes the transient structures at ultrashort intervals at the atomic/molecular level. The novelty of the technique has been demonstrated in gas phase as well as surface and materials science problems but there is a lot of room for improvement.If successful, we will construct a novel, state of the art UED instrument and use it to : (1) Probe the structural change during relaxation of photoexcited DNA, seeking to identify the contribution of spectroscopically dark channels, detectable only with UED, and (2) Image transient structures in reaction dynamics problems involving cluster chemistry and conical intersections
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular study of the regulation of endothelin-1 synthesis by tumor necrosis factor alpha - characterisation of receptors and intracellular signaling' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Endothelial dysfunction in cardiovascular diseases such as atherosclerosis and hypertension is an important factor contributing to the high morbidity of these conditions. The role of cytokines, such as tumor necrosis factor (TNF), play in regulating endothelial cell function and increasing the severity of these diseases is poorly understood. Recent evidence indicate that cytokine-stimulated synthesis of the vasoconstrictor peptide endothelin-1 contributes to the pathological changes. The aim of this project is to identify the TNF receptor and signal transduction pathways responsible for TNFa-induced endothelin-l production in human endothelial cells. Specific TNF receptor neutralising antibodies and selective receptor depletion (by antisense technology) will be used to identify the receptor involved. TNF receptor signaling will be investigate using inhibitors of known signal transduction pathways, by studying TNFa-induced protein phosphorylation, and by identifying proteins which bind to the cytoplasmic domain of the TNF receptor. This work will yield new insights into regulating endothelial function in inflammation and cardiovascular diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Radically Electrified Cyclic Dividing Wall Column: Systems Integration, Optimization and Control' (RE-Cy-DWC).

assistant: **Innovation**

The RE-Cy-DWC project aims to develop a novel, energy-efficient, and sustainable distillation process by integrating cyclic distillation (Cy-Dist) and dividing wall column (DWC) technologies with process electrification. Distillation is a key process in the chemical industry, but it is highly energy-intensive and relies heavily on fossil fuels. This project addresses the challenge of reducing energy consumption and carbon emissions in distillation processes by combining process intensification (PI) and power-to-heat (PtH) solutions. The primary objectives of the project are to: (i) develop mathematical models for the RE-Cy-DWC process that optimize its energy use and carbon efficiency; (ii) design and implement advanced control systems to maintain operational stability and product quality, even under dynamic conditions; (iii) integrate electrification technologies, such as heat pumps, to further enhance energy savings and reduce CO2 emissions. The project’s approach will lead to a 20% improvement in energy efficiency and a 30% reduction in CO2 emissions compared to conventional distillation processes. The results of the project will directly contribute to the European Union’s goals for industrial decarbonization and net-zero carbon emissions by 2050, aligning with the EU’s Work Programme on climate action and sustainable industries. By advancing low-carbon distillation technologies, the project will provide tangible benefits to industries such as chemicals and energy, enabling a transition towards more sustainable production methods. The knowledge generated will be disseminated through open-access platforms, workshops, and publications, ensuring its broad impact across both academia and industry.


**Keywords:** Distillation; Decarbonization; Electrification; Process de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hybrid Energy Storage System' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The development of solutions with the capability of efficiently managing the energy produced by renewable sources and providing fast response as a back-up system or for frequency regulation is a major need in the energy market. While the former has been traditionally satisfied by using batteries, the latter is mainly covered by fossil fuel dependent technologies. Batteries allow for a significant increase of penetration of stochastic renewable energy sources but are unable to satisfy transient events requiring high power responses. In the case of fossil fuel technologies, a set of well-known drawbacks (high operation costs, fuel dependency, pollution and power supply instability, etc.) shows that these solutions are not the most suitable ones from economic and environmental perspectives.In order to overcome this situation, Wind Inertia proposes HESS, a hybrid storage solution that integrates in a single system, ultracapacitors’ (UC) high power density and robustness, Li-ion batteries’ energy storage density, advanced power electronics and control and management systems. The result is a solution capable of combining and optimizing the use of multiple types of energy resources (renewable, fossil fuel dependent and storage).The expected outcome of this proposal is the elaboration of a feasibility study and a business plan aiming at verifying the technological, practical and economic viability of the technology describing their most suitable business model, exploitation strategy, etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Urban Logistics as an on Demand Service' under Horizon 2020.

assistant: **Concept**

A consortium led by 3 municipalities (pilot cities) committed to zero emissions city logistics (Bremen, Mechelen, Groningen) has joined forces with logistics stakeholders, both established (e.g. UPS) and new comers (e.g. ViaVan) as well as leading academic institutions in EU to accelerate the deployment of novel, feasible, shared and ZE solutions addressing major upcoming challenges generated by the rising on-demand economy in future urban logistics.To do so, the ULaaDS project will work on 3 key focus pillars: i) co-creation process to model future on-demand scenarios for urban logistics and definition of relevant ULaaDS delivery solutions through novel toolkit; ii) deployment of 2 ULaaDS solutions co-created (combining new delivery vehicles and novel horizontal collaboration models) through a total of 6 multistakeholder research trials in the 3 pilot cities; iii) assessment of feasible value cases towards urban planning integration (SUMP/SULP).The ULaaDS solutions will be designed complying with a framework of requirements highly aligned with the call topic and ETP ALICE research priorities. The 3 pilot cities propose 2 preliminary ULaaDS solutions building upon their SotA activities solutions to be further concretised through first project pillar: 1) modular innovative cargobikes operated by crowdsourced couriers to enhance logistics efficiency and multimodality in city centres; 2) integration of urban dual transport services (high on-demand distribution requirements of small goods with on-demand shared personal transport - eVans offering pooling for cargo, semiAGVs, public transport)Finally, ULaaDS also involves 4 other satellite cities (Rome, Edinburgh, L’Hospitalet, Bergen) which will also apply the novel toolkit created in ULaaDS as well as the overall project me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Adapting plant growth and development to local time'.

assistant: **Concept**

The day/night cycle of light and darkness make a predictable event, which plants and other organisms have developed means to anticipate. To be able to synchronise life processes with the environment, an endogenous, biological clock drives the rhythmic regulation of many plant processes. The same clock controls crucial seasonal events, such as flowering, dormancy and tuber formation via the measurement of day length. By using the latest technology, we aim to deepen the knowledge of the light regulation of the clock by studies of the light receptor phytochrome B. We will also identify and characterise new genes coding for proteins that restrict the timing of the clock to keep a 24-hour cycle. This will be obtained by the identification and characterisation of mutants impaired in this function. The results from the proposed project will ultimately be applicable in agriculture and forestry by enabling means to extend the geographic range of crops. At present many crops are geographically restricted since their growth are adapted to their local environmental conditions. The means to genetically adapt crops to other environmental conditions by resetting their clock functions will bring a larger diversity of crops. This would profit farmers, since they would find new produce, and consumers would have a greater choice of locally grown varieties. Increased diversification would also give means for a more sustainable agricultural practise.