RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unravelling gamma delta T cell emergence and responses in the uterus' (UTERUS).

assistant: **Innovation**

Gamma delta (gd) T cells constitute a small proportion of blood lymphocytes, but are enriched at barrier sites, where they reside in close contact with epithelial cells. Their location at sites of pathogenic insult and cellular transformation, together with their ability to promptly respond to tissue alterations, places them in a central position in immune protection. We have shown that epithelial molecules direct the development of tissue-specific populations of gd T cells. Indeed, we have identified a role for epithelial-expressed butyrophilin-like (Btnl) proteins in driving the development of epidermal and intraepithelial gd T cells. Importantly, the requirement for Btnls is conserved in intestinal gd T cells in humans. In this project, we will focus on uterine gd T cells, which are arguably one of the least understood populations of gd T cells. These cells bear a specific, invariant T cell receptor, and are thought to become precommitted to an IL-17A-secreting programme during early ontogeny. In other tissues, these cells, termed gd17, can rapidly produce the pro-inflammatory cytokine IL-17A following infection, thereby contributing to limiting infection with bacterial and fungal pathogens. In addition, gd17 cells have been shown to play a role in tissue repair, including promotion of fracture repair. However, the inflammatory effects of IL-17A can also lead to exacerbation of tissue damage and to a pro-tumorigenic effect. In this project, we will determine the functional characteristics of uterine gd T cells, and identify novel factors guiding the development and homing of these cells. Understanding the cues driving gd T cell development and activation at specific body niches is not only essential from a basic research standpoint, but may reveal novel drug targets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multisensory integration in the cognitive representation of space' (MULTISENSORYSPACE), addressing dissemination and exploitation.

assistant: **Impact**

Remembering the position of objects is crucial for the navigation through daily-life environments like buildings and cities. In spite of the fact that environmental sensory information is inherently multimodal, the research on object location memory is still almost exclusively focused on the visual domain. In this Fellowship project, we propose an extensive analysis of the cognitive mechanisms and brain correlates of object location memory for non-visual and multisensory objects. In a series of innovative experiments that combines behavioural and neuroimaging techniques we will test memory for the location of auditory, tactile and multisensory objects in direct comparison to the memory for visual objects position. We will also test the influence of gender and blindness on multimodal object spatial mapping. This topic is original and have an important applicative resonance for the design of effective spatial navigation tools in blindness, for neuropsychological rehabilitation and diagnosis and for the exploration of real and virtual multisensory spatial environments. This study could also give an important contribution to the theoretical debate about cognitive representation of space.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthesis of novel ansa-bis - imido - chromium complexes and investigation of their catalytic activity in olefin polymerisation and romp' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The research project is directed towards the synthesis of novel, well-dcfined, ansabis(imido)chromium complexes, isolobal analogues of the technologically important group 4 ansametallocenes. Figure 1. The isolobal relationship between dr metals of group 4 metallocenes (Ti. Zr, Hf) and group 6 bis(imido) complexes (Cr, Slo,W). The bite angle" of the ligand is crucial for the catalytic activity of the complexes as demonstrated for ansa-zirconocene compounds. The bite angle will be tailored by adjusting the length and type of the linkage, between the two imido groups. The imido groups stabilises the metal in its highest oxidation state and it offers a number of options for different organosubsituents. These tools will be used to modify the ligand frame of the complexes. Ansa-bis(imido)chromium dichloro complexes will be the precursors for the synthesis of carbyl, alkylidene and cationic complexes. The catalytic activity of these complexes in olefin polymerisation and ROMP (ring opening metathesis polymerisation) will be investigated. Figure 2. Schematic representation of bis(imido, ansa-bis(imido) and cationic ansa-bis(imido) chromium complexes. The host research group has the expertise and facilities required for the successful development of the project. Professor Gibson's group has good contacts with industry which will provide an excellent opportunity to explore the potential applications of the complexes. This training will enable me to develop skills relevant to both the academic (ligand design and complexes characterisation) and industrial environments (catalyst testing and polymer studies). "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular and Cellular Mechanisms of Glioma Genesis' (GLIOMAGENESIS) targeting Seventh Framework.

assistant: **Abstract**

Glioblastoma (GBM) is the most aggressive form of glioma, the most common primary brain cancer in adults. GBM is highly resistant to standard radiotherapy and chemotherapy treatments and thus represents a leading cause of cancer-related death worldwide. Although many genetic alterations have been identified for GBM, its histogenesis is still poorly understood. The relative contribution of each genetic alteration and their downstream effects, as well as the sequence of molecular and cellular events required for tumor formation, are not well known. My group is interested in understanding the cellular and molecular mechanisms that underlie the formation of high-grade gliomas such as GBM. My previous work has identified the transcriptional regulator Id4 as a factor that inhibits tumor growth and antagonizes the tumorigenic effects of Olig2, a key regulator of GBM development. However, Id4 has also been shown to drive tumorigenesis. In my first objective (Aim 1), I propose to clarify the role of Id4 in gliomagenesis. Using genetically defined mouse models of glioma and primary GBM cultures, I will test whether Id4 function varies depending on the cellular and molecular context of the cell of origin. In my second objective (Aim 2), I propose to characterize the successive stages leading from the transformation of cells of origin to tumor development, and the individual and combined contributions of defined genetic alterations. I will use a mouse glioma model in which one can label, in a time- and cell type-specific manner, neural cells in which defined genetic alterations are introduced. The proposed project will better define how the genetic and cellular contexts can influence the function of a transcriptional regulator, such as Id4, in gliomagenesis. In addition, the projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Use of extremophile Helianthus species to mitigate climate change impact on feedstock and ecosystem services provided by sunflower' (HelEx) targeting Horizon Europe.

assistant: **Abstract**

Climate-resilient sunflower crops can help to reduce the EU dependency on imports of vegetable oils and proteins shifting towards sustainable alternatives, to mitigate the impact of agricultural production on water use and greenhouse gas emissions, to grow resources for pollinators, and to promote biodiversity.HelEx will generate the knowledge and use innovative tools to accelerate the breeding of sunflower varieties adapted to extreme drought and heat stresses, while improving their environmental impact and assessing their socio-economic value of the resulting innovations along the value chains. HelEx will thereby consider two related groups of traits increasingly impacted by climate change, i.e. the eco-systemic service to pollinators and seed quality. For this, HelEx brings together scientists, SMEs, and industries representing an international consortium of experts in sunflower ecology, physiology and genomics; plant biotechnology and breeding; pollinator biology and ecology; environmental impact assessment and feedstock processing; and socioeconomic assessment at different scales.This HelEx multi-disciplinary consortium will explore the genetic and molecular processes involved in tolerance to drought and heat in wild extremophile Helianthus species, and identify favorable wild alleles introgressed into cultivated sunflower, for seed quality and pollinator attractiveness resilience (WP1). These processes will be transfered using classical marker-assisted selection and innovative genome editing approaches (WP2), and the environmental and biodiversity impact of these new climate-smart sunflowers assessed (WP3). HelEx will investigate the socio-economic impact and benefits in relevant value chains for different feedstock (WP4). Our communication strategy (WP5) will eng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Experimental Aero- and Thermal investigation for a next generation Engine Exit Module' to be submitted under Horizon 2020.

assistant: **Abstract**

A unique facility for experimental testing of engine exit modules (EEM) at engine-realistic flow conditions is currently available at Chalmers University of Technology and will be used to address this JTP action. The unique design of the facility includes an open test section which permits investigation of the complete EEM assemblies consisting of a turbine rear structure (TRS) and a core exhaust nozzle. The facility is equipped with a 1.5 stage shrouded low-pressure turbine (LPT) providing realistic inflow to the tested EEM. The parameters of the facility completely fulfil the requirements specified in the topic description. Thus, the LPT blade height, the flow Reynolds number range, the LPT flow coefficient, the LPT load coefficient, the LPT exit swirl angle range, the LPT hub-to-tip ratio and the purge flow are as specified. The instrumentation of the facility also completely fulfils the topic requirements. Multi-hole pressure probes are available upstream and downstream of the tested EEM. Both traversing systems are covering an entire 360-degree sector of the test section from hub to shroud. Furthermore, in practically all modern techniques of the flow and heat transfer diagnostics are available in the facility. This includes a complete set of equipment and software for PIV (particle image velocimetry) including high-speed stereo-PIV, tomographic-PIV, long-distance micro-PIV and endoscopic micro-PIV. Furthermore, equipment and software for surface oil-flow visualisation and oil-film interferometry, hot-wire and hot-film interferometry, pressure- and temperature-sensitive paints, digital image correlation (DIC), naphthalene sublimation, liquid-crystal thermography and IR-thermography are available as well. Personnel in the workgroup is highly skilled in using all the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Social Jet Lag: Avian Solutions to Misalignment between Circadian Clocks and Social Cues'.

assistant: **Objectives**

Organisms and their cells exhibit alternating phases of activity and inactivity that are regulated by internal ~24h (circadian) clocks. These clocks synchronize to natural fluctuations in day-light, but also likely respond to other factors including the activity of the social group.Here, we propose to investigate how individuals cope with misalignment between their circadian clock and social time (“social jet lag”) – a phenomenon studied in only few species (mainly humans and other mammals) and rarely tested in groups of more than two individuals. Specifically, we will investigate how groups achieve collective synchrony when their members have circadian clocks with different periods or entrained to different environmental cues. Multidisciplinary investigations (physiological, behavioural, and ecological) will be conducted on groups of Red Knots (Calidris canutus islandica) - the hosts’ well established avian model. The project will combine the applicant’s expertise in collecting and analysing extensive circadian datasets, the hosts’ experimental set up in the world’s only tidal aviaries, and the partner’s expertise on an array of circadian clock measurement tools, including a novel molecular method never experimentally applied in birds before.This unique investigation of social jet lag in a non-human social animal will have three main implications. First, it will test the applicability of a new method to quantify circadian clocks for avian research in general. Second, it will reveal how individuals cope with social jet lag and synchronize to the timing of their group – an important topic in the field of ‘time research’ which, according to the recent “foresight” study, is one of six fields of key importance for scientific and technological development. Third, it will hel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tandem Electrocatalytic Reactor for energy/Resource efficiency And process intensification' to be submitted under Horizon 2020.

assistant: **Abstract**

TERRA project aims to develop, from TRL 3 to 5, a tandem electrocatalytic reactor (TER) coupling an oxidation reaction to a reduction reaction, with thus the great potential advantage of i) saving resources and energy (needed to produce the oxidant and reductants for the two separate reactions), and ii) intensify the process (reduce the nr. of steps, coupling two synthesis processes and especially eliminating those to prepare the oxidation and reduction agents). The proposal address one of SPIRE Roadmap Key Actions  “New ways of targeting energy input via electrochemical”. The TER unit may be used in a large field of applications, but will be developed for a specific relevant case:  the synthesis of PEF (PolyEthylene Furanoate), a next generation plastic. TERRA project aims to make a step forward in this process by coupling the FDCA and MEG synthesis in a single novel TER reactor, with relevant process intensification. Between the elements of innovation of the approach are: i) operation at higher T,P than ""conventional"" electrochemical devices for chemical manufacturing, ii) use of noble-metal-free electrocatalysts, iii) use of novel 3D-type electrodes to increase productivity, iv) use of electrode with modulation of activity, v) possibility to utilize external bias (from unused electrical renewable energy) to enhance flexibility of operations. In addition to scale-up reactor and test under environmental relevant conditions (TRL 5), the approach in TERRA project is to address the critical elements to pass from lab-scale experimentation to industrial prototype with intensified productivity. These developments are critical for a wider use of electrochemical manufacturing in chemical and process industries. ""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Assessment of Quality of Power Beam Weld Joints'.

assistant: **Innovation**

Despite significant improvements in power beam welding technology over recent years, it still remains impossible to characterise laser and EB welds in a unique fashion and to produce quantifiable mechanical properties.  Guidance on design aspects of power beam welded joints is currently lacking for potential users so that they are often reluctant to opt for such a welding process despite the availability of the technology.  The objective of this industrial project is to provide an improved understanding of the failure behaviour of similar and dissimilar laser and EB welds in order to be able to predict structural performance.  The project programme extended current non-destructive (NDT) and destructive testing standards to power beam welded joints and provided recommendations for best practise and the changes necessary to current techniques to achieve this.  In order to accomplish this, it is necessary to:i) Identify major weldability and joint quality problems for various materialsii) Develop techniques for the identification of defect types (NDT) and determination of mechanical and fracture behaviour of jointsiii) Develop and validate a methodology - European Quality Assessment Concept (EQAC) - for structural integrity assessment of power beam welded joints which takes into account the unique features of these jointsiv) Provide a first Weld-Defect-Catalogue for power beam weld joints using improved NDT methodologyThe European Quality Assessment Concept (EQAC) for power beam welds developed in this project considers the unique features of power beam welds and their defects on various materials.  Present mechanical and NDT standards do not take into account these features (strength mismatch, defect types, and weld shape etc) of power beam welds in a unified fashion.  Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Developing humour literacy: analysing production, content and reception of humour  to bring positive change in the public sphere'.

assistant: **Objectives**

The goal of the project is to find out how humour literacy can be used to reframe the conflicts and controversial issues in the public sphere and bring benefit to European society by promoting dialogue rather than conflict.  Humour literacy is understood to be an ability to decipher the signs, references and messages that humorous discourse evokes, and an awareness of the benefits and risks of presenting these messages in humorous form to different audiences, public and private, such as a risk of humour failure, humour scandal, or discriminatory humour. Humour literacy has not been systematically and cross-culturally studied before. We plan to fill this gap by employing a comprehensive analysis of humour on all levels of the communication process: production, content and reception, which corresponds to the three R&I work packages of the project. We want to reach our goal by conducting interviews with humour producers (artists, standup comedians, cartoonists), collecting and analysing humorous content, as well distributing questionnaires and conducting focus group discussions with humour recipients  (e.g. visitors of humour or cartoon museums). The staff exchange between 23 partner institutions (15 academic and 8 non-academic ones) from 11 EU and 3 non-EU countries over the period of 48 months. It will be organized in such a way as to create synergy by combining the professional and culture-specific expertise of the academic project participants, who represent diverse fields of study including linguistics, folkloristics, sociology, critical literacy, second language teaching, political communication and computational analysis, with that of practitioners. This will ensure the knowledge exchange between academic and non-academic partners as well between EU and non-EU partn