RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular Basis for Unwanted Side-Effects During Interferon Therapy' (MBFUSEDIT) under Seventh Framework.

assistant: **Objectives**

First-line immunomodulatory treatments such as beta-interferons (IFN-alpha/beta) for multiple sclerosis are available to reduce the rate of relapses and disease activity. However, in addition to its therapeutic effect, systemic IFN-beta treatment causes severe neuropsychiatric complications in humans, including depression and cognitive impairments. These side effects are common and can limit the treatment utility. Our long-term goal is to elucidate the molecular mechanisms of these unwanted side effects in order to improve IFN-beta therapy. The specific hypothesis is that systemically applied IFN-beta exerts adverse side effects by activation of the respective receptor of type I interferons (IFNAR) in the central nervous system (CNS). To identify the actual cell type targeted by IFN-beta in the brain, we have generated brain-specific and glia-specific IFNAR-deficient mice. With the help of these animals we will determine which interferon-stimulated genes will be activated in the brain upon systemic IFN-beta application. We will further assess the contribution of central IFNARs to IFN-beta mediated “sickness” behavior, which includes depressive-like behavior and cognitive impairment and we will correlate these behaviors to changes in hippocampal synaptic plasticity. Together, these experiments will be crucial to identify neurobiological mechanisms responsible for the unfavorable side effects accompanying IFN-beta therapy and to evaluate interventions to ameliorate them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'A micro-level analysis of violent conflict'.

assistant: **Innovation**

MICROCON proposes to significantly increase knowledge in the field of conflict analysis in Europe, through the construction of an innovative micro level, interdisciplinary approach. This approach will promote in-depth understanding of individual and group interactions leading to and resulting from violent mass conflicts. The project aims to uncover much-needed fundamentals for better informed domestic, regional and international conflict policy, which places individuals and groups at the centre of their interventions. In order to achieve these aims, MICROCON builds an integrated approach, which will lay the foundations for the development of a new European interdisciplinary research agenda in conflict analysis and policy.The project entails six specific goals: 1.To create and develop conceptual breakthroughs in the understanding of micro level processes that lead to and result from the full cycle of conflict 2.To compile and collect, and develop methods for the collection of, qualitative and quantitative data on violent conflict at the individual, household and group levels 3.To advance and develop appropriate theoretical and empirical methods for the analysis of violent mass conflict at the micro level 4.To build and disseminate a constructive narrative on micro level conflict processes for the use of European and international policymakers and practitioners, which will influence positively and constructively the design of effective and sustainable policy actions along the full conflict cycle 5.To train and facilitate the mobility of young researchers in Europe, as well as talented researchers in developing countries interested in pursuing advanced studies in Europe in cutting edge theoretical and applied interdisciplinary methods of conflict analysis 6.To manage and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spatial Quantification of Cellular Metabolism in the  Tumor Immune Microenvironment' (SpatialTMEMetabolism) targeting Horizon Europe.

assistant: **Abstract**

The success of cancer immunotherapy, especially immune checkpoint inhibition (ICI), demonstrates the ability of the immune system to fight tumors. However, only a fraction of patients benefit from currently available therapies, and we need to find novel approaches to improve clinical responses. Cellular metabolism has emerged as a key determinant of multiple aspects of immune cell function, especially T cell exhaustion and anti-inflammatory macrophage polarization. However, we currently do not have a good understanding of the metabolic states of human immune cells since no technology has been available to quantify them directly in clinical tumor tissues. I hypothesize that tumors create spatially defined metabolic environments, also called metabolic niches, to suppress immune cells and that this mechanism can be targeted to improve cancer immunotherapy. To test this, we will (1) quantify the metabolic states of immune cells in solid human cancers, (2) identify metabolic immune cell states that predict response to ICI, and (3) reveal the mechanism of metabolic niche formation in tumor organoids. We will quantify cellular metabolism and phenotype directly in human tumor tissues, using the innovative single-cell metabolic profiling (scMEP) approach I have recently developed. We will combine this with multiplexed ion beam imaging (MIBI), a technology that enables 40-dimensional proteomic imaging. MIBI imaging will be complemented by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and machine learning frameworks for the analysis of these multi-omic datasets.Taken together, this project will uncover generalizable concepts of how different tumor entities influence the cellular metabolism of immune cells to modulate their function. The potentia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced Technologies for future European Satellite Applications' in the context of a Horizon 2020 call.

assistant: **Objectives**

Space is key asset for Europe. Europe’s citizens enjoy the benefits, from jobs and economic growth, to public services, efficient communications and security. To respond to global challenges,  Europe must continue to have a prominent role in space at a time when other world powers are rapidly developing their space capabilities. Since satellite payload RF components and systems are essential for delivering mission objectives and supporting ground equipment and telecommunication systems, new technologies and techniques are required to respond to emerging satellite applications and technology challenges. To this end, TESLA ETN will create a vibrant, multidisciplinary training-through-research environment uniquely equipped to develop the Advanced Technologies for future European Satellite Applications. It  will recruit, train and supervise 15 ESRs, who will collaborate with senior staff in academic and industrial sectors to conduct top-notch research into new and enabling technologies for satellite flexible payloads, big constellation systems and Internet of Space,  satellite high-speed communications and remote sensing, as well as large satellite platforms. TESLA will also implement a unique  cross-disciplinary and cross-sectorial training program, underpinned by the recent vision for Europe on open innovation, open science and open to the world, with the objectives to train the next generation of creative, entrepreneurial and innovative satellite communication developers, to provide all network ESRs broad training in transferable skills to enhance career perspectives in both the academic and non-academic sectors, to ensure that all network ESRs have the opportunity to complete a full PhD degree program, to enhance the European space economy and business through the provi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Combined CO2 reduction and biomass valorization' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Using CO2 as a raw material for the production of fuels and chemicals plays a crucial role in achieving an environmentally friendly andcircular economy. The objective of this project is to create a (photo-)electrochemical process that converts CO2 into methanol at the(photo-)cathode while simultaneously utilizing biomass for the anode reaction. Methanol is one of the top five chemicals produced inlarge quantities, historically relying on fossil fuel-derived feedstocks. Its well-established supply chain makes storage andtransportation convenient. Traditionally, water oxidation has been the primary anode reaction, but its slow reaction kinetics and thelow-value product (oxygen) make it less economically attractive. As an alternative, we propose replacing water oxidation with theoxidation of hydroxymethylfurfural (HMF). HMF oxidation offers a range of valuable products and more favorable reaction kinetics.This project encompasses various aspects, including material development, catalytic testing, optimization of reactor parameters, andadvanced characterization techniques to establish the photophysics and reaction mechanisms involved. This comprehensiveapproach enables the rational design of photoelectrocatalytic systems and advances our understanding of how to harness light andelectricity for catalytic processes, ultimately contributing to a greener industry and sustainable development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of Relevant Approaches to Mathematically Model Increasingly Complex Microbially-driven Processes' (DRAMATIC).

assistant: **Concept**

Mathematical modelling has played a central role in understanding the fundamental characteristics and behaviour of ecological systems for over a century. In microbial systems, modelling has attempted to reveal the dynamics and interactions of simple co-cultures of organisms in chemostats through to more complex systems with highly diverse functionality. In real-world processes, such as engineered biological systems, EBS, (activated sludge, anaerobic digestion), the former models are incomplete for characterisation of the functional microbial diversity, whereas the latter models are intractable to mathematical analysis, rendering them as inadequate. The Fellowship will investigate the suitability of current mechanistic approaches to modelling for EBS using chemostat theory, but also exploring the analysis of higher dimensional models. The fellow will undertake their outgoing phase at McMaster University to develop their skills in dynamical system theory, applied to real-world systems and observed microbial ecological behaviour in various forms. This will include the use of both analytical and numerical methods to understand system stability and the detection of emergent properties. Recent advances in the understanding of the limits of classical Monod-type growth functions has given rise to new approaches including stochastic and diffusion-based models. However, mathematical investigation of these alternative concepts is not yet fully realised. The fellow will bridge the gap between microbial ecological theory, modelling and mathematical theory to understand the practical possibilities and predictive capabilities that can be exposed when rigorous analysis is achieved. As part of the return phase, he will spend a period at INRA, France, to investigate the validation and ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Smart Home security device based on infrasound detection technology'.

assistant: **Innovation**

With a home burglary taking place every 0.8 seconds in Europe, people’s increasing concerns for both personal and property security is propelling the Smart Home Security market. A host of hardwired, wireless, and compact self-contained Smart Security systems is commercially available, embedding motion detectors, door/window sensors, and video cameras. However, the latest market researches on consumers’ expectations emphasise a gap between what is currently available and the consumers’ quest for affordable, reliable, easy to use and stylish home devices. LYT SONIC’s mission is to change the way home security is delivered, by integrating an innovative infrasonic detection technology into a smart LED bulb, to be easily plugged into any lamp holder end/or socket. The core innovation is represented by the advancement of the infrasonic detection technology, the new frontier in the security industry, whose development is being pioneered by few companies with still limited success. Through a proprietary algorithm able to pinpoint the source of the infrasound signal LYT Sonic represents a simple, affordable, reliable and intuitive product for smart home security. LYT SONIC infrasonic waves’ sensor collects environmental sounds and, through a WiFi connection, transmit them to a software application with a machine learning algorithm able to analyse the event, discriminate false and true alarms, and control both the alarm system and home lighting. The benefits are highly valuable to the users:1) Immediate installation and easy portability. 2) Low price, in the range of 110-160 €, and no maintenance costs. 3) Total coverage of the house (up to 120 m2 with a single light bulb). 4) High reliability, thanks to the proprietary pattern recognition algorithm which profiles the sound waves
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Green cement of the future: CemShale + CemTower' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Cement is the most consumed resource after water. Currently more than 4 billion tons of cement is produced every year. Cement production currently contributes 8% of global CO2 emissions. Supplementary cementitious materials (SCMs) are used to supplement cement to reduce carbon footprint of it. Today, the main SCM is fly ash, by-product of coal driven power plants. As these power plants are phased out, fly ash availability is becoming scarce. Cement industry players are already eagerly looking for alternatives.CemGreen has developed CemShale, a process that calcines shale in granules instead of powder and delivers a high performing clay mineral based SCM. Shale is abundant and often lying unused in many cement plants. In addition, CemGreen developed a game-changing equipment for optimised heat treatment of shale granule material, vertically integrating three separate equipment in conventional cement production: the preheater, kiln and cooler, allowing for heat treatment within narrow limits and significantly reducing operational costs.Cemshale offers high cement substitution rates, while CemTower Capex is a fraction of cement production Capex. Cemshale will provide cement producers SCM supply chain flexibility, significant cost savings and possibility to meet CO2 emissions lowering targets.Full implementation of our solution has the potential to lower worldwide CO2 emissions by 4.81%. CemShale has global potential to become the state-of-the-art SCM and CemTower the state-of-the art product equipment thereof.CemGreen has filed patent applications on CemShale and CemTower. The project will place CemShale in the forefront of new SCMs, having an extremely high global potential of €63 Bn and creating ~650+ new jobs already within 5 years of commercialisation.


**Keywords:**
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'A European Approach to Conflict Resolution? Institutional Learning and the ESDP'.

assistant: **Objectives**

To what extent can international institutions learn? What factors determine whether such institutions develop capacities for self-awareness and endogenous institutional change? This project investigates these questions in the context of the European Union (EU). Specifically, it examines the dramatic expansion in security missions led by the EU since 2003, a capacity that many observers doubted was even possible for the EU. To explain this change in institutional behaviour, the project intends to develop a theory of institutional learning to analyze the EU’s instigation and implementation of 16 security operations in various regions under the auspices of the European Security and Defence Policy (ESDP). In addition, with these missions the EU has shown a growing capacity to innovate in security affairs, using a unique civilian crisis management (CCM) capacity linked to security sector reform and other EU policy tools, including the ESDP, the Common Foreign and Security Policy (CFSP), and the European Neighbourhood Policy (ENP). These changes demand further examination in light of not only the growing ambitions of the EU itself but also in terms of the increasing demands for security assistance placed on a variety of IOs, such as the UN, NATO, and the OSCE. The initial phase of the project will focus on four key ESDP operations as detailed case studies – Macedonia, the Palestinian Authority, the Democratic Republic of the Congo, and Bosnia-Hercegovina – to explain this innovation. Following the investigation of these representative cases, the later stages of the project will examine more recent EU security operations in hopes of developing a general theory of EU institutional learning in the area of foreign/security/defence policy. The project also hopes to generalize beyo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Improving the Effectiveness of the Capabilities (IEC) in EU conflict prevention'.

assistant: **Objectives**

The European Union (EU) is increasingly affected and challenged by geopolitical changes, increasing impact of conflict on civilians, globalized impact of local conflicts, technological developments and budgetary constraints challenges the Radicalization, the growing potential for individuals to create large security threats and transnational criminality further complicates the security landscape of EU missions. With global interconnectedness, the repercussions of outside conflict are also seen within the EU, and may lead to societal and security challenges within the EU. The key issue for the EU is how to improve its conflict response capabilities to create more lasting impact on the ground and to use limited resources more effectively. Comprehensive EU-security within the EU emphasizes the need for civil-military synergies, which correspond more closely to challenges on the ground and the incorporation of very different perspectives, priorities and operational cultures.  The IECEU–project analyses and assesses best practices and lessons learned with a view to enhance the civilian conflict prevention and peace building capabilities of EU with a catalogue of practices, new solutions and approaches. It will seek to find out how to increase the interoperability of resources in the crisis management and peace building and what the potential for pooling and sharing of EU capabilities and technologies is. The main goals of the IECEU -project are:1) Analysing and assessing the current situation of on-going and past missions and operations2) Learning from lessons provided by these missions and assessing the different options 3) Providing new solutions, approaches and recommendations for EU to guarantee long-term stability