RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Geosphere INfrastructures for QUestions into Integrated REsearch' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Geo-INQUIRE will provide and enhance access to selected key data, products, and services, enabling the dynamic processes within the geosphere to be monitored and modelled at new levels of spatial and temporal detail and precision. Geo-INQUIRE aims to overcome cross-domain barriers, especially the land-sea-atmosphere environments, and will exploit innovative data management techniques, modelling and simulations methods, developments in AI and big data, and extend existing data infrastructures to disseminate these resources to the wider scientific community, including the EOSC landscape. Geo-INQUIRE benefits from a unique partnership of 51 partners consisting of major national research institutes, universities, national geological surveys, and European consortia. Geo-INQUIRE will enhance and make interoperable the activities of the involved partners and conduct dedicated training programs for their optimal use. A portfolio of over 150 Virtual Access (VA) and Transnational Access (TA, both virtual and on-site) installations will be offered to the scientific community. While many such resources are already available at a high level of maturity, Geo-INQUIRE will ensure that they not only reach the highest level of scientific excellence through targeted actions on availability, quality, and spatial and temporal resolution, but also that they follow FAIR principles, adopt proper standards and open licenses, and aim at cross-disciplinary interoperability. Furthermore, the integration of different data, including new observables, products, and services will be optimized through TA activities via 6 test beds, which will also host workshops and summer schools dealing with the available resources. Ultimately, Geo-INQUIRE, with its enhanced data, product, and service portfolio, will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multiscale Charge-Transport Simulation of Organic-Based Materials and Devices' (TRANSSIM) under Seventh Framework.

assistant: **Objectives**

This project aims at developing innovative multiscale computational tools for tackling charge transport in organics materials (organic crystals, organic thin films, etc.). Based on some combination between first principles calculation and mesoscopic transport approaches, We will investigate charge transport in materials of strong technological interest, at an advanced realistic level. The method will take into account strong electron-phonon coupling and related polaronic states, as well as material imperfections (disorder) on the same footing. The exploration of temperature dependent charge mobility will be undertaken for bulk as well as for low dimensional organic compounds. A close interaction with local experimental groups will be conducted.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Crimean-Congo Haemorrhagic Fever Vaccine and Immunotherapy' (CCHFVACIM) under Horizon Europe.

assistant: **Objectives**

The CCHFVACIM project is an ambitious collaborative effort aimed at developing both prophylactic and therapeutic effective countermeasures against Crimean Congo Haemorrhagic Fever Virus (CCHFV), one of the most threatening vector-borne pathogens, widely distributed, including in the European continent. Deep structural biology studies on viral glycoproteins and investigation of the immunogenicity of the viral antigens will be combined with optimisation of an mRNA vaccine candidate against the virus and characterisation of the resulting protective immunity, as well as with the development of immunotherapeutic monoclonal antibodies (mAbs) based on CCHFVs antigenic targets.To achieve the overarching goals, the CCHFVACIM project will build on the success of previous projects such as CCHFever (FP7), CCHFVaccine (H2020) and go the extra mile by initiating a unique One-Health platform strategy to address different aspects of this severe public health threat. On one hand, the project will use several advanced animal models (mice, sheep, and non-human primate) to assess and compare the efficacy of mRNA vaccine candidates, mAbs and therapeutic mRNA; on the other hand, it will establish a biobank from CCHF patients to build up a pipeline for the production of mAbs against CCHFV from their B cells.Importantly, the project will also contribute to capacity building of European infrastructures, with the establishment of a platform on mRNA-based vaccine at one of the partner institutions. Ultimately, CCHFVACIM will permit to develop a road map to bring the most efficacious vaccine candidates and immunotherapy tools to clinical trial Phase I in humans. The project results will be widely disseminated among the scientific community, public health authorities, non-governmental organisations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structure, assembly and metal ion binding properties of the catalytic core of a group II intron ribozyme' (RNABIC).

assistant: **Innovation**

Group II introns are one class of naturally occurring catalytic RNAs, ranging between 600 and thousands of nucleotides in length. These ribozymes catalyze a variety of reactions, among which the self splicing activity is the most prominent one. These large molecular machines are found primarily in organellar genes of plants, fungi and lower eukaryotes, but also in many bacteria. Metal ions are crucial for folding and activity of catalytic RNA molecules, however their structural and mechanicistic roles are poorly understood. Many biochemical studies have been performed in the past, but few structural information is available on group II intron ribozymes. Here we plan to structurally characterize by NMR the kappa-zeta region of domain 1 of the group IIB intron Sc.ai5gamma, originating from the cox1 gene in yeast mitochondria, both in the absence and presence of metal ions, in addition to investigate its docking to domain 5. The kappa-zeta region is the most central part of these ribozymes as not only it represents the nucleation core of intron folding but its complex with domain 5 comprises the largest part of the catalytic core. This dual role underlines the significance of any new information on structure, metal ion binding and domain assembly gained of these fascinating molecules, which are considered ancestors not only of the spliceosome but also of large part of the eukaryotic genome. Belonging to action 2 of the FP7 “Work Program-PEOPLE” this project intends to train an experienced researcher in the (for her) novel fascinating field of “Coordination Chemistry of nucleic acids”, a field at the interface between Chemistry and Life Science, two different Marie Curie panels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Elucidating the role of SALMs in the regulation of synapses and NMDA receptors' (SALMANDNMDA) under Seventh Framework.

assistant: **Objectives**

Cell adhesion molecules (CAMs) mediate many critical processes in the mammalian brain, including formation and maturation of synapses. CAMs have been implicated in cognitive diseases, such as autism and schizophrenia, as candidate genes. These studies highlight the importance of understanding the mechanisms by which CAMs participate in normal and pathophysiological conditions. Synaptic adhesion-like molecules (SALMs) are a new family of CAMs that are expressed in the mammalian brain. The five SALM family members (SALM1-5) have conserved extracellular N-termini, but differ substantially in their intracellular C-termini. The distinct C-termini suggest the SALMs possess unique functions. In recent studies, over-expression of SALM2 increased the number of excitatory synapses and reduction of SALM5 expression decreased the number of inhibitory synapses. Furthermore, SALM1 directly interacted with the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor. NMDA receptors are key mediators of glutamatergic transmission in mammalian brains and thus a SALM/NMDA receptor interaction would have important functional consequences for excitatory synapses. The mechanisms underlying roles that SALMs play at the synapses and in the functioning of NMDA receptors remain unknown. In this proposal, we will identify regions within SALMs that regulate the formation and maturation of synapses. We will also identify regions critical for the SALM/NMDA receptor interaction, the cellular compartments where the interaction occurs and the role that SALMs play in NMDA receptor functioning. These studies will be carried out using immunocytochemistry, biochemistry and electrophysiology on heterologous cells, dissociated cultures of cerebellar granule cells and hippocampal neurons. Determination of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Foundation for Empirical Multimodality Research' (FOUNDATIONS).

assistant: **Concept**

This project lays a foundation for conducting data-driven empirical research on multimodality, that is, how human communication and interaction rely on combinations of 'modes' of expression. Theories of multimodality are rapidly gaining currency in diverse fields concerned with human communication, interaction and cultural production. However, most theories of multimodality are based on conjecture and remain without an empirical foundation due to the lack of large, richly-annotated multimodal corpora and methods for their analysis.FOUNDATIONS solves this problem by developing a novel methodology for conducting empirical research on multimodality in everyday cultural artefacts, such as newspapers, textbooks, magazines and social media videos. This methodology allows critically examining key theoretical concepts in the field  medium, semiotic mode and genre  and their joint contribution to meaning-making, which renews our understanding of key theoretical concepts in multimodality research and places their definitions on a solid empirical foundation.To do so, FOUNDATIONS creates large and reproducible multimodal corpora using microtask crowdsourcing, which breaks complex tasks into piecemeal work and distributes this effort to non-expert workers on online platforms. These crowdsourced descriptions are combined with computational representations into graphs that represent the structure of multimodal discourse. For analysing these corpora, the project develops novel methods based on neuro-symbolic artificial intelligence, which enables combining crowdsourced human insights with the pattern recognition capability of neural networks.The groundbreaking theoretical and methodological advances in FOUNDATIONS go far beyond state of the art by enabling large-scale empirical researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'ShowerPod'.

assistant: **Innovation**

This project contains of one work package with 10 tasks. The specific objectives for the SME-instrument phase 1 feasibility study are to:• Deeper knowledge of the technical, economic and practical viability of the innovation as a ground for a decision of continuing the innovation process in a phase 2 project or redirect the innovation process (all tasks)• Map where demonstrations actions can be made with varying conditions and geographical location which links to market potential and technological challenges (task 1)• Investigate potential knowledge partners for phase 2 (task 2)• Get deeper market intelligence and define the European dimension for the commercialisation of the innovation (task 3)• Investigate the willingness to pay and perceived benefits by users (task 4)• Develop a communication strategy to be used during phase 2 and 3 (task 5)• Elaborate an exploitation plan including a strategy for pricing, financing and organisational changes needed especially sales and distribution organisation (task 6)• Elaborate an IPR strategy and have full knowledge of the development path i.e. freedom to operate (task 7)• Prepare the innovation for demonstration (to be made in phase 2) including CE-marking of the innovation to enable demonstration in medical clinics (task 8)• Elaborate Business Innovation Plan 1 that takes into account the results of task 1-8 and will present predicted business- and market opportunities (Task 9)• Coordination of the feasibility study (Task 10)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Selective Membrane-Binding Peptides: Computational Design and Experimental Validation for Advanced Biotechnological Applications'.

assistant: **Objectives**

Membrane-binding peptides have significant potential applications, such as antimicrobials, biosensors and in the purification of extracellular vesicles. However, to ensure the effective implementation of these peptides in biotechnological applications, it is essential to prioritize their selectivity. The Opi1 peptide has previously been shown to exhibit a high affinity for phosphatidic acid (PA)-containing membranes. Given the analogous structure of cardiolipin (CL), this proposal posits that it may be possible to develop an Opi1 variant that interacts selectively with CL-containing membranes with diverse CL proportions. Cardiolipin (CL) is exclusively found in the inner membrane of mitochondria and bacteria, making this phospholipid an interesting candidate for the design of selective peptides. The project will entail the implementation of in silico mutations of the Opi1 sequence, in order to identify novel sequences with different affinity to model membranes. The optimization and analysis of peptide-membrane interactions will be conducted through the use of atomic-resolution molecular simulations, alchemical transformations, and experimental biophysical techniques, such as liposome flotation methods and quartz crystal microbalance assay. This interdisciplinary project integrates biology, physics, and chemistry, leveraging advanced computational and experimental techniques to achieve the objectives. The interdisciplinary integration ensures robust outcomes, with potential applications in targeted drug delivery, and diagnostics, ultimately advancing our understanding of peptide-membrane interactions.


**Keywords:** Membrane-binding peptides, antimicrobial peptide, molecular simulations, peptide design, membrane-specific activity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hybrid Battery energy stoRage system for advanced grid and beHInd-de-meter Segments' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

HYBRIS' basis is the optimisation of advanced hybrid systems as high-performant, cost-effective and environmentally-friendly solutions in microgrid applications. HYBRIS is an integrated industrially driven action, that will answer to this challenge in 4 key points:  - Viability and cost effectiveness: of the use and integration of novel HEES system coupled with innovative microgrid system local RREE generation and loads,  (in particular residential, tertiary buildings and EV charges stations). Achieved by the integration and validation of a suite of technologies, tools and methods enabling their easy application and massive deployment. - Technical: pursuing the technical optimization of  the HEES system in 3 use case applications covering respectively 1)  Energy services in island grids 2) Energy services in private grids 3) EV charging stations in e-mobility, - Optimization and integraton. - Validation: by using the 3 demonstration sites as open case studies representing the 3 differrent use case applications and situations found throughout Europe, to leverage knowledge, key exploitable results, adapted business models and market-oriented dissemination for maximizing impact and wide adoption of these novel heating and cooling technologies and approach. HYBRIS features a fully systematic, collaborative and integrated approach to the development and deployment of innovative battery based hybrid storage sytemm, coupling diverse and complementary breakthrough TRL 5-6 technology assets brought by leading industrials, universities and RTOs, plus ICT tools for viable and cost-effective optimization and further market introduction. All will reach TRL6 by the demonstration and validation of its concepts in 3 use cases applications in 3 pilot sites in 3 four countries


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Combinatorial Construction'.

assistant: **Concept**

Combinatorial Construction is a mathematical challenge with many applications. Examples include the construction of networks that are very sparse but highly connected, or codes that can correct many transmission errors with little overhead in communication costs. For a general class of combinatorial objects, and some desirable property, the fundamental question in Combinatorial Construction is to demonstrate the existence of an object with the property, preferably via an explicit algorithmic construction. Thus it is ubiquitous in Computer Science, including applications to expanders, sorting networks, distributed communication, data storage, codes, cryptography and derandomisation. In popular culture it appears as the unsolved `lottery problem' of determining the minimum number of tickets that guarantee a prize. In a recent preprint I prove the Existence Conjecture for combinatorial designs, via a new method of Randomised Algebraic Constructions; this result has already attracted considerable attention in the mathematical community. The significance is not only in the solution of a problem posed by Steiner in 1852, but also in the discovery of a powerful new method, that promises to have many further applications in Combinatorics, and more widely in Mathematics and Theoretical Computer Science. I am now poised to resolve many other problems of combinatorial construction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Future and Emerging Technologies for the Virtual Physiological Human' (VPH-FET).

assistant: **Concept**

The Virtual Physiological Human (VPH) is an initiative, supported by the European Commission, to create a computational framework to facilitate the understanding of the integrative function of molecules, cells, tissues, and organisms and, by this, to construct a multiscale in silico model of the human physiology.Specific Calls within Framework 7 have addressed the VPH, and the first set of VPH projects has just completed its first year. In general, the tasks associated with blending the disparate work of scientists who are used to working at a specific scale into a multiscale arena, of ensuring that the data and software to be shared amongst them has no incompatibilities, and other issues linked with implementing these ambitious large-scale plans have necessitated a focus mostly on what has to be accomplished immediately to achieve specific short-term objectives.This means that a number of issues that go beyond the needs of individual projects and underlie the whole of the VPH Programme are being disregarded for the present. A few of these have already been identified. Tackling them will involve a level of risk that normal Framework priorities would probably regard as too high. Nevertheless, devising suitable solutions to these problems would provide a huge impetus both to the VPH scientific programme and to VPH participants by extending their focus from the current rather narrow issues to areas in which success could provide VPH with progress on a broad front.To this end, VPH-FET will produce a Roadmap for VPH technologies that entail a certain level of risk but which, nevertheless, would provide significant benefits if suitable solutions could be found. These challenges are generally newly-emerging and will have received little concerted attention previously. By provi