RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Time  Task management solution for SMEs to Improve Focus and Maximize Work Efficiency' under Horizon 2020.

assistant: **Concept**

Controllability and the availability of relevant, real-time data (serve as basis on business decisions) are crucial factors in company’s life and daily operation. Taskfit PRO task management software which builds on the commercially available Taskfit software (http://basewalk.com/product-video/) gives a unique solution for such challenges. Taskfit PRO is a task management solution that helps to structure the company’s clients, projects, tasks and manage them in a unified system. It provides availability to the latest, up-to-date information in the system without manual data upload. Taskfit PRO runs as a background application that can be controlled through a small dashboard on the screen. New tasks/projects can be created and started by a simple double-click, after which the system automatically registers the working hours spent with the execution of the given task/project. Switching between tasks can be managed by a click, too. When switching to a task, all files (regardless of the format or extension) related to the given task/project become available immediately – without any extra searching and browsing through irrelevant folders and files. Separation of documents and files related to a single task is ensured by the fact that Taskfit PRO provides a single Windows desktop for each created task/project. BaseWalk, the creator of Taskfit was established in 2009 and piloted the first Taskfit prototype in 2010. Since then, they have executed pilot projects with large and small companies and presently have hundreds of users locally and internationally. To help maximise the commercialisation of Taskfit PRO, BaseWalk set up a list of new functions and improvements based on feedback from existing clients and decided to apply for SME Instrument funding together with Nuage who
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The transfer of knowledge to facilitate the identification of novel pre-clinical active compounds for use as candidates in pharmaceutical drug discovery research' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Tripos Discovery Research Ltd. (TDR) is a contract research company supplying the pharmaceutical industry and is based in Bude, Cornwall. It is one of the largest employers in this Less Favoured Region, and is undergoing significant expansion to meet current business requirements. TDR has developed a synthetic chemistry / computer software based approach to medicinal drug discovery.This uses proprietary chemical library design technology (ChemSpaceTM), high throughput synthetic chemistry and sophisticated informatics. Support through a ToK Development Host Scheme is sought to enable TDR to develop it's own pre-clinical lead discovery programs, implement in-vitro biological and pharmacokinetic screening in-house and increase the scope of the research services that it offers.TDR has already made important contributions to several recent drug discovery projects and the knowledge that TDR intends to introduce is very complimentary to its current operations. New medicinal drugs are important in improving the quality of life for many people within the EU and produce economic benefits for those companies manufacturing them and for the community through improved healthcare. The pre-clinical lead discovery programs for which TDR is seeking knowledge transfer cover a broad area i.e. biological targets and medicinal chemistry related to the kinase, GPCR and protease families.The combination of this knowledge with TDR's existing strengths of high throughput chemistry and library design will provide chemistry based opportunities across a range of targets with potential applications and new drug opportunities in a number of important therapeutic areas (e.g. Cancer, Asthma, Arthritis, Alzheimer's disease). Additionally, and again building on existing TDR strengths, software and in-vit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Chiroptera-Inspired Robotic Cephaloid: a Novel Tool for Experiments in Synthetic Biology' (CIRCE) under Fifth Framework.

assistant: **Objectives**

The goal of this project is to reproduce, at a functional level, the echolocation system of bats in a bionic bat head that can then be used to investigate how the world is not just perceived but actively explored by bats. This bionic bat head, of similar size to a real bat head, will consist of an emission/reception system capable of generating/processing bat vocalisations in real-time and a multi-degree of freedom mechanical system to allow pinnate movement and shape control. Construction of such a bionic head is one half of the work, the other half is to gain more insight into neural sensory-data encoding from use of the head in echolocation tasks routinely executed by bats. In particular, the capabilities of the bionic head for active sensing will allow us to investigate many of the active sensing strategies thought to be used by bats.OBJECTIVESTo construct a bionic head that reproduces at a functional level the echolocation system of bats it must be of similar size to a real bat head in order to reproduce the relevant physics. Hence, we plan to develop new, small, ultrasonic transducers with controllable beam width; neuromorphic cochlea models capable of extracting biologically plausible features from the complex echoes in real-time; new, small, actuators to control a multi-degree of freedom mechanical system that allows realistic pinnae movement and shape control. The bionic head will then be mounted on a robot arm/mobile robot to use its active sensing capabilities in exploring features present in the sensory data as well as their neural encoding.DESCRIPTION OF WORKTo attain the double objective --constructing a bionic bat head of size similar to a real bat head and to use that bionic bat head to gain more insight into neural sensory-data encoding in an active sen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A novel approach for the integration of biomass pyrolytic conversion processes in existing markets of liquid fuels and chemicals' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives The proposed integrated approach has the following objectives: - Pyrolysis of various feedstocks, e.g. straw, arundo donax, hardwood (eucalyptus species) and softwood (pine species). - Evaluation of characteristics of qualified feedstocks (ultimate and proximate analysis and calorific value). - Optimization of flash pyrolysis and combustion processes to increase liquid yields and improve liquids quality. - Close-coupling of existing biomass conversion (CFB reactor), post treatment (product stream dedusting and pyrolysis vapour quenching) and upgrading (plasma reactor) processes - Derivation of scale-up rules for flash pyrolysis plants. - Setting-up of requirements for risk analysis of integrated advanced pyrolysis systems including detailed study on technoeconomics for either heat or power applications. - Proposals for the removal of barriers to introduce pyrolysis liquids to niche markets, e.g. refinery infrastructure. Technical Approach In the framework of previous R&D programmes, a novel reactor configuration, suitable for the maximisation of the liquid products derived from biomass flash pyrolysis has been constructed and tested. It is a Circulating Fluidised Bed (CFB) reactor, which is fuelled by partial combustion of the byproducts of the pyrolytic process. This is achieved by recirculation of the byproduct char to the lower portion of the CFB reactor, where it is combusted, providing the energy requirements to carry out the biomass devolatilization process. Results have shown total liquid yields of 55-60% wt, based on maf feedstock. However essential process modifications (e.g. hot gas filtration and liquid recovery based on direct quench of pyrolysis vapours)are required to improve quality and further increase liquid yields. Moreover, the liquid produ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mass spectrometry for nucleic acid biophysics : dealing with diversity' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

There is now increasing evidence that specific nucleic acid structures modulate gene expression levels both at the transcriptional and at the translational level. In particular, G-quadruplex (G4) structures are attractive targets for anticancer strategies, since several studies showed that their stabilization by ligands caused proliferation arrest, telomere deprotection and changes in gene expression. Understanding the structure-function relationships in G4 DNA and RNA requires innovative biophysical tools to probe the general and specific features of the structures adopted by a wide variety of sequences, their macromolecular assemblies, and their interactions with small molecules. I propose here to develop native mass spectrometry and ion mobility spectrometry as biophysical tools to probe small molecule ligand interactions with G4 structures. My recent work on small (~20-30 bases) G4 models demonstrated that MS is uniquely well suited to detect and quantify G4-drug interactions in a direct binding assay. The objective of the present project is now to characterize not only the binding affinity and specificity but also the binding mode of ligands for a variety of DNA and RNA targets. Ion mobility spectrometry will be crucial for studying the conformational adaptability of the target, and ligand-induced conformational changes. The model targets will vary in sequence, but also in size. Indeed, one still widely unaddressed challenge is to account for the flanking sequences that can form secondary structures and tertiary structures interacting with the G4 and, in the case of genomic non-B-DNA targets, to include the adjacent and competing double-stranded DNA. The biophysical approaches developed here for a specific purpose (G4 ligands) will also be widely applicable to othe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'REMODELLING OF THE INFARCTED HEART: PIEZOELECTRIC MULTIFUNCTIONAL PATCH ENABLING THE SEQUENTIAL RELEASE OF THERAPEUTIC FACTORS' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Cardiac disease remains a major societal and healthcare burden that affect nearly two million European citizens every year.The REBORN project brings together a consortium of six scientific, four SME, and two large company partners who are committed to making a step-change to the development of medical devices for cardiac applications for the treatment of people who have suffered from a heart attack (myocardial infarction, MI). A MI causes fibrosis in the heart walls, which impedes cardiac function and means there is a high risk of subsequent heart failure post-MI. There are no current treatment options to address this major clinical problem. The REBORN project will use smart and multifunctional biomaterials to deliver a new medical device in the form of a cardiac patch, to be applied to the heart in order to stimulate and support local heart tissue remodelling. The piezoelectric patch will electromechanically couple with the heart and deliver anti-inflammatory, anti-fibrotic and cardiomyocyte proliferative factors on demand, with drug release triggered by ultrasonic (US) stimulation from outside the body. Development of the device will be based on new smart multifunctional materials: electrospun piezoelectric fibres combined with smart carriers designed to work in harmony with the US. To prepare the ground for exploitation, the patch will be extensively characterised in vitro and in vivo. Accelerating the development of the patch requires an effective in vitro model for experimentation, and novel 3D bioprinting techniques will be exploited to create a 3D in vitro model in the form of a tissue engineered tubular heart chamber, capable of pumping fluid using cell contractile forces. This will give a new in vitro model capable of both functional and structural testing. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Detecting epigenetic biomarkers in the blood for non-invasive precision oncology' (EpiDetect).

assistant: **Concept**

The detection of circulating tumor DNA allows to non-invasively retrieve tumor molecular profiles and follow disease evolution. These approaches promise optimal and individualized management of patients with cancer. However, despite remarkable progress, several technological obstacles still limit liquid biopsy widespread application. Indeed, detecting small fractions of tumor DNA released when the tumor burden is reduced remains a challenge. Samples collected at early stages or during treatment may contain less than one mutant copy per milliliter of plasma, which is below the detection limit of current technologies. Moreover, detectable recurrent mutations do not cover all patients. It is therefore necessary to develop new, more sensitive, but also more informative tools. My goal is to develop new methods detecting epigenetic markers from peripheral blood for establishing more efficient non-invasive diagnostic tests and disease monitoring. Targeting the cancer epigenome, which contains a myriad of somatic alterations that do not modify the DNA sequence and cover cases without detectable mutations, will achieve increased sensitivity. These markers could become decisive in detecting residual disease and early stages of multiple forms of cancer. I will develop approaches to: 1) Analyze circulating DNA methylation profiles at unique and repeated sequences; 2) Identify circulating DNA cells of origin using nucleosome footprint; 3) Analyze transcripts associated with circulating extracellular vesicles. Ultimately, a single test integrating DNA methylation profiles, fragmentation patterns and EV-associated transcripts, from the same plasma sample, will be developed.This project has both fundamental and biomedical implications: it will generate in-depth knowledge of the biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Public Space Navigation for All' (PAL), addressing dissemination and exploitation.

assistant: **Impact**

PAL aims to perform a feasibility study and elaborate a business plan testing out the innovative idea of making public spaces accessible for All. The PAL idea is simple: provide an indoor navigation service similar to what we are used to when driving. The project focuses on users with specific needs especially elderly and visually impaired persons who need to find their way through complex travel hubs and train stations. Although the idea is simple, its implementation is quite challenging. There are numerous technologies involved (indoor localisation, mapping, routing, information presentation) which have to be mastered. Fortunately, in PAL we base on technology the partners have developed in previous projects, notably MOBILITY funded by the German Ministry for Education and Research, and successfully tested at the Frankfurt airport.PAL will assess the technological viability, the application boundaries, the value added, the business model, and the economic viability of this MOBILITY solution with a single focused aim to work out a credible, realistic and achievable business plan.IN2 and SPRING, the partners in this endeavor, have successfully collaborated in the past in MOBILITY, own its project results and are fully committed to bring them to the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Photo-controlled two-dimensional soft materials from microgel particles at liquid interfaces'.

assistant: **Concept**

Microgels are valuable building blocks both for investigating colloidal phase transitions and for the fabrication of complex materials that react and adapt to external stimuli. In particular, liquid interfaces are perfect two-dimensional (2D) templates for microgel assembly because of the long-range ordered organization that can be achieved in a fast and reliable manner. The structure of microgel assemblies at liquid interfaces can be precisely controlled by changing external parameters (e.g, temperature, pH, surface pressure). The microgels volume and compressibility can be modulated, in turn affecting their mutual interactions and final organization. The goal of this multidisciplinary proposal is to develop novel systems where light actuation can be coupled in to control microgel properties at liquid interfaces. Up to now, the external stimuli used to control 2D microgel assemblies had several limitations: the lack of spatial resolution, a poor control over the response time, and the irreversibility of the transitions. With the proposed systems, an optical trigger will allow the external control of the inter-particle interactions as well as of the particle size and compressibility with exceptional spatial and temporal resolution. Two synthetic routes are considered: i) covalent modification of the microgel structure with the addition of light-responsive co-monomers; ii) mixing of microgels with photoresponsive surfactants. Different responses are offered by these two strategies. In the former case, unprecedented local control over microgel assemblies can be achieved, opening the way to novel studies over 2D phase transitions. In the latter case, a composite system is proposed, where microgel properties, as well as macroscopic surface flows, can be manipulated by light
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The green revolution for the Industry 4.0.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

AEinnova’s INDUEYE 2.0 sensing technology aims to help big industries to digitalize easily, costly-effectively being environmentally friendly. In this sense, the European Industry has an opportunity to increment their productivity being more sustainable. Focused on Energy Intensive Industries with big facilities in explosive environments (called ATEX) as oil&gas, chemical, petrochemical, food and wood industries they have significant limitations to achieve the Industry 4.0 transition. In detail: -Energy: Powering wired sensors requires high investment in wiring (50€/meter of wire) whereas wireless sensors require maintenance (batteries replacement cost about 300€ every 6-24 months).-Communications: Wired sensors need high investment in infrastructures whereas wireless in order to save battery use low-range protocols needing repeaters (i.e. Wifi or Bluetooth).-Data representation: Big industries use SCADA to represent data. It isn’t flexible, not accessible to historicals, nor web-based/mobile nor predictive maintenance.-ATEX. Wireless IoT holds lithium battery that is explosive and highly contaminant. They cannot be installed in explosive environments forcing all sensors to be wired.Moreover, these big industries are highly inefficient due to they lose 65% of their energy needs in the form of waste heat (1.4PWh yearly  or the 21% European energy needs). AEinnova creates the first wireless industrial IoT device that solves these limitations. It’s a batteryless, free-of-maintenance, wireless long-range, self-powered by heat and ATEX taking all the advantages of all the state of-the-art. Also, all the data is presented in a Software-as-a-Service IoT web-based dashboard with reports and analytics. The technology’s kernel is protected by patent in EU, USA and Canada patent.