RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Complement: to clear or not to clear'.

assistant: **Concept**

Mammalian complement recognizes a variety of cell-surface danger and damage signals to clear invading microbes and injured host cells, while protecting healthy host cells. Improper complement responses contribute to diverse pathologies, ranging from bacterial infections up to paralyzing Guillain-Barré syndrome and schizophrenia. What determines the balance between complement attack reactions and host-cell defense measures and, thus, what drives cell fate is unclear.My lab has a long-standing track record in elucidating molecular mechanisms underlying key complement reactions. We have revealed, for example, how the interplay between assembly and proteolysis of these large multi-domain protein complexes achieves elementary regulatory functions, such as localization, amplification and inhibition, in the central (so-called alternative) pathway of complement. Results from my lab underpin research programs for the development of novel therapeutic approaches in academia and industry.Here the goal is to understand how the molecular mechanisms of complement attack and defense on cell membranes determine clearance of a cell. Enabled by new mechanistic insights and preliminary data we can now address both long-standing and novel questions. In particular, we will address the role of membrane organization and dynamics in complement attack and defense. Facilitated by recent technological developments, we will combine crystallography, cryo-EM, cryo-ET and high-resolution microscopy to resolve complement complex formations and reactions on membranes. Thus, this project aims to provide an integrative understanding of the molecular complement mechanisms that determine cell fate. Results will likely be of immediate importance for novel therapeutic approaches for a range of complement-rela
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Activation tagging as a means of plant gene isolation' (1994-1998).

assistant: **Concept**

Though the majority of the worlds major crop plants can now be transformed, one of the most pressing problems we face is the relative lack of plant genes of agronomic worth currently available for transfer into novel host plants. This proposal centers on the use of activation tagging" to isolate plant genes controlling the expression of genes encoding proteins with a function in either developmental, or biochemical pathways relevant to biotechnology. Activation tagging involves the use of a gene tag engineered to contain transcriptional enhancer sequences. Following the insertion of such a tag into the plant genome, the expression of flanking sequences becomes deregulated, producing a dominant mutation. Notably, the dominant mutation produced allows a direct selection for a defined phenotype among the population of primary transformants. Hence, selection schemes can be devised for the expression of genes of agronomic potential. In addition to the transcriptional enhancers, the tag contains sequences derived from a bacterial plasmid, thus allowing rescue of tagged genes directly in bacteria with relative ease. To date, activation tagging has been used successfully to create plant mutants whose cells are able to proliferate in the absence of auxin, or cytokinin, in the culture media, as well as mutants resistant to chemical, or metal, selection. This project involves the further development of this tagging strategy to isolate genes playing a role in a) shoot/root formation, b) control of transcription of enzymes of lipid biosynthesis, c) the plant`s response to pathogens and d) DNA recombination. To carry this out novel selection schemes have been devised including the use of transgenic plant lines engineered to contain markers which normally remain inactive in plant cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SHOWCASing synergies between agriculture, biodiversity and Ecosystem services to help farmers capitalising on native biodiversity' (SHOWCASE) targeting Horizon 2020.

assistant: **Abstract**

The slow adoption by the agricultural sector of practices to promote biodiversity are thought to originate from three interrelated issues. First, we know little about which incentives effectively motivate farmers to integrate biodiversity into daily farm management. Second, few studies so far have produced evidence that biodiversity-based approaches produce benefits in terms of key variables for farmers (yield, profit). Third, there is a large communication gap between the scientists investigating biodiversity-based farming practices and the farmers that have to implement them. To overcome these barriers, SHOWCASE will review and test the effectiveness of a range of economic and societal incentives to implement biodiversity management in farming operations and examine farmer and public acceptance. Focus will be on three promising approaches: (i) result-based incentives, (ii) involvement in citizen science biodiversity monitoring and (iii) biodiversity-based business models. SHOWCASE will co-produce together with stakeholders a solid interdisciplinary evidence for the agro-ecological and socio-economic benefits of biodiversity management in 10 contrasting farming systems across Europe. SHOWCASE will also design communication strategies that are tailor-made to farmers and other key stakeholders operating in different socio-economic and environmental conditions. SHOWCASE will develop a multi-actor network of 10 Experimental Biodiversity Areas in contrasting European farming systems that will be used for in-situ research on biodiversity incentives and evidence for benefits as well as knowledge exchange. This network will be used to identify and test biodiversity indicators and targets relevant to all stakeholders and use them in a learning-by-doing approach to improve benef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cordless voice operated computers for manufacturing operations' (1994-1998).

assistant: **Innovation**

The specific industrial objective of this cooperative research project is to design, develop and demonstrate a cordless, voice-operated computer process control system that offers significant productivity and safety improvements over processes which normally require a considerable degree of direct human intervention in order to maintain output quality. There are many such processes throughout the various manufacturing sectors in the European Union. Indeed, nearly 85% of all European industrial manufacturing SME's have some degree of human process control in their key manufacturing operations. This will be achieved through the fulfilment of technical objectives relating to :- the t of a voice recognition system with 99% + accuracy and repeatability in a shop-floor manufacturing environment with high levels of operator physiological stress and acoustic ambient noise the developmne of a computer based voice synthesis system providing clear and positive acoustic feedback of operator requested control actions allowing true hands free" or "eyes busy" closed loop process control achievof "voice recognition and synthesis on the man" to minimise data transfer times, avoid communication channel brandwidth crowding for multi-operator processes, give fast and efficient process control action to maximise process throughput without compromising quality and increase productivity . achievement of demonstrably successful and stable control interaction and feedback with a variety of different types of process by voice command alone These objectives will be achieved by combining the current "state-of-the-art" in speech recognition, speech synthesis and process control sad developing it further to produce a new technology that (with further post-project development) will be industrially ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Disease and stress resistant common Carp: Combining quantitative, genomic, proteomic and immunological makers to identify high performance strains, families and individuals' (EUROCARP).

assistant: **Innovation**

The common carp is the most important farmed freshwater fish species in the world. Eastern European carp genebanks have been responsible for the selective improvement of carp for intensive and semi-intensive pond culture in Europe and their dissemination worldwide. Several serious disease problems such as Koi herpesvirus (KHV), and erythrodermatitis (Aeromonas salmonicida and A. hydrophila) threaten carp farming in many countries. Selection in carp has tended to develop high performing but inbred strains f or crossbreeding.The inclusion of disease and stress resistance as traits within breeding programmes will require the use of modern quantitative and molecular genetic tools. Disease resistance has proved to be a difficult trait to assess and improve in fish, direct challenges on potential broodstock run the risk of turning such fish into carriers. Functional genomics, proteomics and gene mapping will identify candidate genes and QTLs for resistant fish without a challenge.Heritability estimates for viral and bacterial resistance and genetic correlation to performance traits will be assessed. Differences in gene expression within high and low, viral and bacterial, resistance families with and without challenge will be assessed using a 20K gene carp micro-array. Differences in serum/plasma protein expression and immunological parameters will also be assessed. Congruence between expression levels and protein production will provide evidence for the importance of particular genes or Gene ontologys (GO) in these processes.Progress will also be made towards to development of a second- generation medium resolution gene map that will be an important tool for the future development of improved strains of carp. The results from the quantitative genetic and molecular data will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of the neural cell adhesion molecule L1 and its ligands in normal brain development and hereditary brain diseases' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

During development of the nervous system, axonal growth, neuronal migration and synapse formation are essential. As the embryonic nervous system differentiates, neurons produce axons that travel through diverse and changing environments of the developing animal to find their appropriate targets. When target cells are reached, synapses are formed. Synaptic plasticity is important, not only during establishment of the neural network, but also in the adult organism in which a continuous modulation of synaptic connections is essential for the dynamic functions of the brain such as learning and memory storage. An understanding of the molecular basis of axonal growth and guidance both during normal development and in relation to brain diseases is therefore an important issue in developmental neurobiology as well as in clinical neurology and neuropathology. The aims of the proposed collaboration are to provide an extensive characterization of a key molecule, the neural cell adhesion molecule L1, involved in axonal growth, neuronal migration and synaptic plasticity. The characterization includes localization of binding sites for the homophilic (L1) and heterophilic ligands the cell adhesion molecules Axonin- 1, F11, NCAM and laminin. Furthermore, L1 interaction with the fibroblast growth factor receptor, which probably mediates signal transduction, will be characterised in detail. The binding sites will be characterised in regard to their localization, structure and binding affinities, thus enabling the preparation of agonistic and antagonistic ligands, which may allow the development of compounds beneficial for the treatment of neuro-degenerative disorders. The proposed collaboration involves seven leading European laboratories, six academic and one industrial laboratory. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Photosynthetic electron focusing technology for direct efficient biohydrogen production from solar energy'.

assistant: **Innovation**

We propose a disruptive technology based on synthetic biology, we call photosynthetic electron focusing, for the efficient production of hydrogen using low-cost photosynthetic bacteria (cyanobacteria) genetically re-engineered to exclusively direct the solar energy to hydrogen. Through the development of new high-efficiency large-scale photobioreactors we will obtain an unprecedented increase in the energy efficiency up to ten-fold higher than current approaches. Our theoretical estimates for the production costs could be as low as 5€/Kg of H2, making our technology potentially comparable to current photovoltaic coupled to electrolysis. Our bacteria could be adapted and grown in sea water and wastewater. Moreover, it would not require using Critical Raw Materials or toxic processes. Our biological route involves using fermentation-like technologies, with expertise available in many sectors such as the food industry. It will also employ contained bioreactors, constructed with simple fabrication technologies, which are decreasing in cost (e.g., the cost of 3D printing materials is decreasing much faster than the cost of microfabrication). We will validate our engineered cyanobacterium in a custom 1,300 L photobioreactor, which will be able to produce validated innovative green H2 production technology. This proof-of-concept production will be located in a hydrogen industrial stakeholder to ensure the large-scale relevance of our production.


**Keywords:** Synthetic Biology, Cyanobacteria, Photobioreactors, Biohydrogen, Photosynthesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Experimental and numerical studies for evaluation of surface integrity in post-processing of additively manufactured nickel-based alloy by machining process' (AMacSurface).

assistant: **Concept**

As a new technology, Additive Manufacturing (AM) provides an excellent opportunity to produce parts with complex geometry that would not be possible with traditional manufacturing methods. Against several advantages of AM technology, surface quality of an AM-built part might not be suitable for many applications. To solve this issue, one must use post-processing by machining process to obtain a suitable surface quality and dimensional accuracy of parts produced by AM. Regarding the machining processes, the desirable surface integrity of the machined components is one of the dominant requirements of the industries because it significantly affects the performance and service life of the final products. Inconel 718 alloy, as a difficult-to-cut material, has excellent properties. Not only few experimental studies are found in literature on machining of AM Inconel 718 alloy, but also, they have mostly limited to Conventional Machining (CM) processes. In addition, very few studies are found in literature on machining simulation of this new material due to absence of reliable material model for modeling the chip formation. To address this gap and aiming to push the fundamental science behind this problem, the main goal of the present project is to comprehensively evaluate the surface integrity condition after machining of AM Inconel 718. Firstly, the correlation between main AM parameters and machining characteristics are investigated. Then, a comparative experimental study will be conducted on CM, Cryogenic Cooling Machining (CCM) and Laser-Assisted Machining (LAM) to obtain desirable surface integrity after machining of AM Inconel 718 alloy. After that, fundamental advances for machining simulation of AM Inconel 718 will be presented. Based on this, identification of the new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AUTOMATED PROTOTYPE OF CANCER DETECTION FROM CTDNA' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Floating Genes is a French deeptech startup incorporated in October 2021, developing early cancer detection tools from liquid biopsies. The company focuses on digestive cancers, and especially colorectal and pancreatic cancer, which is mostly detected in stage 4 and show 4.3 month of median survival. Floating Genes has developed and patented molecular biology tools to detect very rare circulating tumor DNA (ctDNA) in the blood. This will eventually allow earlier cancer diagnosis, precise monitoring and personalized treatment of patients with cancer. 200,000 lives could be saved every year in Europe with such an earlier diagnosis tool.


**Keywords:** Cancer detection, liquid biopsy, NGS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hyperbolic systems of conservation laws' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The training contents of this project are based on the committment to in the theory of Hyperbolic Systems of Conservation Laws, one of the most invest human and financial resources for a 9 postdocs program. We plan classical and important part in the theory of Nonlinear Partial to have a summer school dedicated to postdocs and to use existing and future relations with industrial research groups. Differential Equations. The proposed research area is of strategic interest because it has a preminant role in Applied Mathematics. Indeed it is between the most relevant tools used in Engineering and Applied Physics modelling. We intent to investigate the most relevant application of the theory to a large variety of models and in the meanwhile develop the hard core of the theory. Our research proposal will cover both theoretical and numerical aspects We believe that it is necessary for the Community to became stronger and competitive in this area. The non EEC teams, operating on the same subject, receive (particularly in USA) a strong financial support by their national research programs. Our proposed network has 8 teams in 6 countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European surveillance system on contact allergies-data centre' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Contact allergy is frequent and has a great socio-economic impact. With the aim of providing scientific information necessary for primary prevention, the European Surveillance System on Contact Allergies (ESSCA; 30 partners from 13 countries) was founded. All partners record data pertaining to patients tested for contact allergy, either on paper or in PCs. Since there would be considerable added value in sharing these data, both a computer program for local use and a co- coordinating data centre will be implemented. Collected data is quality checked, transformed (in view of heterogeneous EDP systems) and analysed in the centre. ESSCA-DC intends to co-operatively evaluate pooled European data to meet the following objectives yet unmet: early recognition of(I) sentinel events concerning emerging contact allergens, or(ii) novel exposure contexts for known allergens, with the ultimate aim of improved consumer and workplace safety.