RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Resolving the molecular mechanisms of intracellular coral-algal symbiosis'.

assistant: **Concept**

Many cells stably integrate microbes to gain ecological advantages for the organism. A remarkable example is the symbiosis between corals and algae, whose provision of photosynthetically fixed nutrients enables coral survival in nutrient-poor habitats. To establish symbiosis, coral cells acquire symbionts via phagocytosis, a process often used for pathogen clearance in other animals. Symbionts reside in phagosomes, and the prevailing view is that, similar to some pathogens, symbionts avoid destruction via phagolysosomal manipulation. Yet, unlike pathogens, symbionts provide nutrients to their host, and this may be key for intracellular persistence. Most research on nutrient translocation has focused on sugars, but surprisingly, sterols may be significant because cnidarians cannot synthesize cholesterol. However, little is known about the underlying molecular mechanisms of symbiosis establishment. Because corals are intractable cell biological models, I will leverage our unique resources and expertise to uncover fundamental aspects of symbiont acquisition and metabolic dependence using the emerging model anemone Aiptasia. To investigate symbiont acquisition (Objective 1), I will distinguish symbiont-phagocytosing cells, test candidate symbiont receptors by gain- and loss-of-function, record symbiont/cell interactions by live-imaging, and generate a symbiosis cell culture system. To understand the significance of symbiont-derived sterols (Objective 2), I will map cellular sterol utilization and identify the sterol transport machinery, test whether symbiont sterols can functionally substitute cholesterol, identify novel sterol-interacting proteins by pull-down assays, and explore symbiont persistence mechanisms using comparative phagosome proteomics. This proposal will for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reinforcing nanostructure laboratory' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Nanostructure Laboratory of Faculty of Physics, University of Belgrade (NanoLab) is well recognized in European nanotube physics community for its original, full symmetry based theoretical, as well as optical and discharge experimental methods for carbon and inorganic nanotubes. Reinforcing this leading Serbian nanoscience research centre is of national importance regarding new technologies development and transfer, as well as dissemination of knowledge substantial for the technological progress. The aim of this project is to strengthen human and material resources of NanoLab, which is necessary to continue and improve high standards theoretical and experimental research and widen its scope. Significant contribution to the brain-drain preventing will be realized through new job opportunities in the cutting edge scientific field (FP6 priority theme 3), and permanent personal development within networking with the leading European research laboratories.Optical characterization methods for thin film growth monitoring, based on luminescence and interference effects, have been developed and applied in NanoLab to control growth of porous aluminium-oxide films used as templates for nanostructures growth. These methods will be combined with plasma enhanced chemical vapour deposition, to produce nanotubes, nanoclusters and thin films. Special attention will be paid to clarify the growth mechanisms and role of plasma, and to develop new optical emission techniques for discharge parameters determination and discharge-surface interaction monitoring. For the optimal control of aluminium-oxide thin films, high resolution wide spectral range, fibber optic fluorimeter is necessary, sensitivity of discharge spectroscopic observations will be increased by low resolution, high light power
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of high-performance barrels with innovative gradient coatings' under Seventh Framework.

assistant: **Concept**

A large amount of plastic raw material is processed by screw extrusion and by screw injection moulding techniques. The degree of equipment wear for these techniques represents one of the issues of greater concern since it determines the economic feasibility of processing, especially in view of increasing filler content of plastics, processing temperatures and throughputs of plants.The main objective of the project is the development of a set of barrels with innovative internal thick coatings, featuring a compositional gradient along their length to optimise the coating behaviour and better face the different tribological and corrosive environments encountered during service in the specific sections of the extruder.DEBACOAT aims to face important challenges:- to overcome the current trial-error approach for applied research and development of new coating solutions- to understand the relationship existing between materials and process parameters for obtaining high-quality coatings and improving their properties- to guarantee reliability and repeatability on the productionThe expected improved performance of the barrels can be specifically achieved by investigating and optimizing the following scientific issues:- R&D feedstock powder formulation for each specific working condition experienced in each section of the extruder;- R&D the chemical composition of the coating both along thickness (radially - as governed by dilution with backing steel) and also along the length of barrel (as governed by differentiated powder composition and specific melting processes);- Processing the barrels by induction heating and spin casting to achieve controlled zone-melting and solidification of the thick coating with a compositional gradient along its length;- Alternative novel processing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transonic High Reynolds Number Testing of a Large Laminar Wing Half Model' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main objective of the present proposal is the performance of wind tunnel testing of a half model at transonic speed and near flight Reynolds number. The model wing featuring a natural laminar flow (NLF) design will be subject to artificially generated surface steps and imperfections allowing investigating the resulting effect on the flow behaviour on the wing. The proposed activities comprise the design and provision of a controlled high pressure air supply inside the model, the model preparation and the test performance. Basic investigations on NLF wings have already been performed in a recently completed EU research project ensuring the availability of test capabilities, tools and appropriate techniques for an achievement of the defined objectives. Forces and moments will be measured with a classical strain gauge balance inside the tunnel ceiling while the PSI system is going to record the large amount of tap based pressure data. Model deformation in wing twist and bending due to aero loads will be monitored by the highly qualified stereo pattern tracking system. The visualization of   laminar flow areas as well as the transition line will be achieved by applying the temperature sensitive paint (TSP) technique, which has been developed and enhanced by DLR and ETW to a mature state over the recent decade. A team of long experienced and highly skilled staff will take the responsibility for a successful performance of the described activities.To meet concerns of the given complexity of the work an extended risk assessment with corresponding contingency plans has been prepared. Exploitation and an enhanced dissemination address the uniqueness of the expected results.The proposed investigations on a Natural Laminar Flow model refer to a key technology stream within the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rebuilding interphase nuclei into mitotic chromosomes' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The remarkable morphological transformation that cells undergo during mitosis has been studied for >140 years, but how mitotic chromosomes are built from interphase nuclei remains unknown and challenging to study. We propose to uncover the mechanisms for this process at high-resolution in cells and in vitro, a task that requires coordinated implementation of innovative experimental designs in several disciplines. We will engineer mutant and hybrid cell lines that enter mitosis with minute-by-minute synchrony, allowing us to develop new “kinetic sectioning” methods to map the intracellular distribution of chromatin near the nuclear envelope, from nucleosomes to mitotic chromosomes at unprecedented resolution, trace the action of individual condensin complexes as they produce loops during mitotic chromosome formation and efficiently isolate mitotic chromosomes for biochemical (4D proteomics) and structural analysis. We will combine genome-wide chromatin mapping, super-resolution microscopy and cryo-ET with innovative image analysis and modelling. In addition to studies of conventional chromosomes, we will study tiny natural ""dot chromosomes"" from chicken cells. Only a few megabases in size, these natural models for their larger counterparts will be isolated for detailed 4D proteomic and structural analysis and used to map scaffold and loop organisation at high resolution. Our team will address mitotic chromosome formation from multiple complementary angles in a synergistic approach where insights from collaborative computational analysis, cross-linking and structural data will inspire and define questions, both predicted and unforeseen. We will discover new insights as condensed mitotic chromosomes are built from active interphase chromatin across a wide range of physic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TALOS Mobile Guides', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The publishing business is currently undergoing a fundamental change in that printed content is progressively replaced by electronic content. While in the case of books this translates to a “simple” switch to ebooks, for mobile guides and geo-enabled content, smartphones brought along an even bigger change as multimedia content can be shown in a context-sensitive way by using for example location.TMGuide proposes to further exploit the research results of the TALOS project (Task-aware location-based services) in the context of Mobile Travel Guides to utilize novel Mobile Guide technology in connection with various smartphone platforms. TMGuide will perform some technological development necessary to bring the respective Mobile Guides to market (automated content production, introduction of additional mobile platforms, addition of geospatial data, and integration with translation services) and will conduct specific demonstration and dissemination activities to showcase the Mobile Guides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Action research: Improving understanding and methodologies in early development'.

assistant: **Innovation**

The ACT Initial Training Network aims to establish a leading European training network devoted to investigating the interplay between action and cognition using a developmental approach. The ACT network represents a collective of scientific and industrial groups at the cutting edge of research in the fields of social development, developmental psychology, cognitive science, developmental neuropsychology, and computational science. The network will train PhD students and produce new technology to answer critical issues in our understanding of human development. A core assumption of the network is that development of perception, motivation, and cognition is grounded in, and develops through, our own actions (von Hofsten, 2004). We learn about our physical environment by actively engaging with the world. As we develop new action capabilities, new elements of the environment become salient to us. This process is especially prominent early in infancy when action capacities and an understanding of the world develop. The nature of developmental research demands a multi-method approach. As a result, we propose to rigorously train ESRs such that they obtain two or more techniques required to study the relationship between brain and behaviour in early social development.   We will conduct research and training within and between academic and industry partners on the role of attention in action, prospective control, social interactions, and semantics in action.  We will improve technologies so that movement analysis is possible with infants. We will also develop an eye tracking system that links to EEG and we will create tools that are designed specifically for infant EEG data. In addition to these major breakthroughs in our knowledge, we will provide a structured training program
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BENCHTOP NMR FOR LAB-ON-CHIP' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Organ-on-a-chip (OOC) devices offer new approaches to metabolic disease modelling and drug discovery by providing biologically relevant models of tissues and organs in vitro integrated with sensing technology. As such, OOC devices have the potential to revolutionise the pharmaceutical industry by enabling reliable and high predictive in vitro testing of drug candidates. The capability to miniaturise microfluidic systems and advanced tissue fabrication procedures have enabled researchers to create multiple tissues on a chip with a high degree of control over experimental variables for high-content screening applications. The objective of this project is to develop a new technology based on magnetic resonance spectroscopy and imaging using dynamic nuclear polarisation (DNP-MR) integrated with OOC devices to monitor disease and evaluate drug response in OOC models. As a proof-of-concept, this project will fabricate a biomimetic multi OOC integrated device composed of liver spheroids and pancreatic islets and develop the necessary DNP-MR hardware and software to study metabolic diseases and for future drug screening applications.


**Keywords:** hyperpolarisation, microfluidics, organs-on-a-chip, radiofrequency engineering, magnetic resonance spectroscopy (MRS)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrating spatial and genetic information via automated image analysis and interactive visualization of tissue data' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Digital imaging of tissue samples and genetic analysis by next generation sequencing are two rapidly emerging fields in pathology. The exponential growth in digital imaging in pathology is catalyzed by more advanced imaging hardware, comparable to the complete shift from analog to digital images that took place in radiology a couple of decades ago: Entire glass slides can be digitized at near the optical resolution limits in only a few minutes’ time, and fluorescence as well as bright field stains can be imaged in parallel. Genetic analysis, and particularly transcriptomics, is rapidly evolving thanks to the impressive development of next generation sequencing technologies, enabling genome-wide single-cell analysis of DNA and RNA in thousands of cells at constantly decreasing costs. However, most of today’s available technologies result in a genetic analysis that is decoupled from the morphological and spatial information of the original tissue sample, while many important questions in tumor- and developmental biology require single cell spatial resolution to understand tissue heterogeneity.The goal of the proposed project is to develop computational methods that bridge these two emerging fields. We want to combine spatially resolved high-throughput genomics analysis of tissue sections with digital image analysis of tissue morphology. Together with collaborators from the biomedical field, we propose two approaches for spatially resolved genomics; one based on sequencing mRNA transcripts directly in tissue samples, and one based on spatially resolved cellular barcoding followed by single cell sequencing. Both approaches require development of advanced digital image processing methods. Thus, we will couple genetic analysis with digital pathology. Going beyond visual asses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Origami electronics for three dimensional integration of computational devices', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Increasing the integrated circuits complexity by lateral scaling, known as Moore’s law, was the major driving force for the semiconductor industry. Now, after more than 4 decades down scaling is approaching fundamental and also economic limitations, and new solutions for further increasing the transistor count are explored. Utilizing the third dimension in chip architecture is one of the most promising directions. However, current solutions like wafer-to-wafer stacking will only deliver solutions for the short term with maximum some tens of layers on-top of each other’s. In the ORIGENAL project we propose a radically new approach to address the challenge of ultra-dense 3D integration of CMOS devices by using a thin-film-transistor (TFT) technology on thin foil substrate and the subsequent topological folding in order to achieve a dense 3D packaging with completely new integration architectures. This radically new approach will enable the stacking of thousands of layers on top of each other’s, each containing state-of-the-art CMOS circuits and thus will provide enough fuel to further increase the transistor count on a chip according to Moore’s law for more than 30 years. In addition, new computing concepts like neuromorphic computing will significantly benefit from the highly interconnected architecture developed in this project.The proposal focuses on the development of a suitable thin-film-transistor technology on ultrathin-foil, the 3D interconnect and architecture, and the required technology for high precision folding. Achieving the ambitious objectives requires an interdisciplinary approach including contributions from Material science, electrical engineering, mechanical engineering, biology, physics and chemistry.The proposed forefront research will not only lay t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Resolving the origins of supernovae: constraining progenitors with integral field spectroscopy' under Horizon 2020.

assistant: **Concept**

Supernovae are cornerstone to understand the chemical and dynamical evolution of the Universe, cosmology and fundamental physics. In spite of the great advances achieved during the last decades, key questions remain open. We propose to determine the binary fraction of progenitors of core-collapse supernovae (CC- SNe) and resolve the turn-on time of type Ia supernova (SN Ia) progenitor systems through exploiting unique trove of integral-field spectroscopy (IFS) data and by developing a new spectral synthesis model to resolve stellar age distributions from 10–200 Myr. The proposer team has access to the largest set of IFS available from the most current leading surveys: MaNGA, CALIFA, and AMUSING. We will develop a new Bayesian single stellar population fitting method which will include at the same time information of the ionized gas and UV, to help constrain the youngest stellar populations, and NIR to better disentangle the degeneracy between age and reddening by dust. We will use IFS data of around thousand galaxies and the new method to recover the star formation histories at every single observed position including the SN position, and use the method presented in Maoz et al. (2010) to recover the delay-time distribution (DTD) of both CC SN and SNe Ia and measure: (i) the shape of the late CC SN DTD tail, to check whether populations of 50–200 Myr are typically associated to CCSN locations which would prove the binary progenitor scenario; and (ii) the lower turn-on age of the SN Ia DTD, to determine the age of the youngest stars producing SNeIa. Finally, we will test the role of different star formation histories at SN Ia locations affect their precision as cosmological distance tools. This proposal is for an ambitious, competitive, and accomplishable project that wil