RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating gene function in development using the model system drosophila' (1998-2002).

assistant: **Concept**

Applications are invited from doctoral students registered in another EU country or associated state to work for between 3 and 12 months in the Developmental Genetics Training Site in the School of Biological Sciences, at the University of Sussex, in the United Kingdom. Opportunities exist for Fellows to experience training in functional genomics within developmental biology, using genetic technologies in the insect Drosophila melanogaster This programme will support Fellows with existing expertise in the developmental biology of this system, but also those having skills in other aspects of this system (for example in toxicology or ecology), or those working with homologous genes in vertebrate development including human medicine, as well as trainees within SMEs that have interests in formulating diagnostics for gene expression and dysfunction. Three alternative experimental systems are available: neural connectivity in developmental neuroscience, the Transduction mechanisms and integration of cell signaling systems active during development, and the molecular events underlying spatial patterning during appendage fonnation. Fellows will use contemporary molecular genetic technology or RNA profiling to investigate specific gene function, and will gain experience in advanced confocal microscopy and image analysis. Applicants should contact Dr J R S Whittle, Developmental Genetics Group, School of Biological Sciences, The University of Sussex, Brighton BN1 9QG, The United Kingdom. Email: j.r.s.whittle@sussex.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel protective coatings for industrial application (PROCOAT)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Recently, efforts of many researchers have been focused on the development of advanced materials with superior characteristics with regards to reliability, endurance and resistance to environmental impacts. Unfortunately, the majority of developed show only short-term advantages while in a long run require often replacements that lead to a great consumption of hazardous paints and volatile solvents. The proposed in this Project work is concentrated on the development of totally innovative technology that will lead to the synthesis of durable and much more reliable and wear resistant coatings. The idea is based an the fabrication of new immobilized functional coatings with an additional polymer inner nano-layer that will result in a forced diffusion of a block-polymer from the intermediate layer to the damaged area. This will constitute the so-called self-healing" effect due to low surface energy component, mechanical stresses and anchoring release."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantifying ecological effects of small hydropower in Alpine stream ecosystems' to be submitted under Horizon 2020.

assistant: **Abstract**

In Europe, hydropower is the largest renewable energy resource accounting for 16% of total production, most of which is concentrated in the Alpine region. However, this renewable energy comes at great environmental costs and development of large dams is now considered untenable in many Countries. While studies addressing the ecological implications of hydropower have mostly focused on large facilities, investigations on small hydropower (SHP) are scarcer. Yet, development of SHP is booming globally and in the Alps rising concerns about cumulative effects on riverine systems.This project proposes a multi-disciplinary investigation to better quantify hydrological alterations from SHP and its effects on Alpine stream ecosystems. Combining field-experiments, surveys and innovative modelling of existing flow data-series, the project will: i) quantify the spatio-temporal scales of hydrologic alterations associated with SHP using integrated analytical tools and modelling approaches applied to long-term, spatially distributed data; ii) experimentally mimic water abstractions from SHP using semi-natural flumes to assess the response of aquatic invertebrates and the link between community assembly and ecosystem function applying the Price Equation partition; iii) quantify flow-ecology relationships and the cumulative effects of multiple SHPs using novel functional regression models with streams hydrographs. The results will provide new insights into the short- and long-term effects of SHP on Alpine streams, with practical implication for the sustainable use of water resources.During the project, I will train intensively in methods and software to quantify and model alterations of river flow and habitat and in handling large datasets. I will exchange knowledge with modellers, engi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Precautionary risk methodology in fisheries' (PRONE), addressing dissemination and exploitation.

assistant: **Impact**

Improved quantitative and qualitative information on the biological, social and economic consequences of current and alternative actions and tools available to fisheries managers are required to better manage the various risks in European fisheries. The main objective of the project is to investigate how risk analysis theory can be adapted to European fisheries management, embracing the full process from stock assessment, projection and advice, via management decisions, to the practical implementation of the management measures, including control. Improved communication of such information to stakeholders and fisheries managements will make it easier to achieve the long term goals of fisheries management, which ultimately aim to impact human behaviour and through this to modulate human impacts on nature. The components to be incorporated include risk identification and probabilistic evaluations of the potential consequences of alternative management actions (risk assessment), the formulation of of tools to manage the risks (risk management), and the development of mechanisms to ensure that the outputs of risk assessment and the risk management options available are adequately understood by stakeholders (risk communication). A variety of potential formal approaches to risk management that have been applied in other relevant fields will be compiled and ones that may have considerable merits for European fisheries management will be identified.The current risk methods are tested and compared to alternative methods. Recruitment models are developed to improve the predictability of future productivity os the stocks. Game theory will be applied to study how international agreements should deal with risk management. The risks caused by dioxin for consumers are studied in Balti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A political economy of ova banking in Spain and Ukraine' under Horizon Europe.

assistant: **Concept**

With the growing international demand for donor ova, Spain and Ukraine have developed into leading suppliers of donor ova for the burgeoning ova donation industry in Europe. The banking of ova and their transnational shipping is the subject of fierce political and ethical debate among policymakers and medical professionals in Europe. While selling human ova is illegal, countries interpret the relevant legislation differently and find regulatory loopholes, which results in an emergence of market relations around the exchange of ova. This growing transnational ova market makes Europe a key nodal point for understanding the process of valuation of human reproductive materials. However, a comprehensive research project on the economic value of ova under different regulatory regimes is currently lacking. CryOVAlue addresses the field’s knowledge gap by asking how the model of ova banking in Spain and Ukraine influences the valuation of ova produced for market exchange. While most of the literature on ARTs focuses on the cultural understanding of reproductive technologies, their restrictions, and experiences resulting from them, CryOVAlue develops a political economic approach. By conducting comparative analysis of the ova banking in Spain and Ukraine, CryOVAlue explores how the value of ova is affected by the countries political and economic position in Europe, and how it shapes the well-being of ova donors. Moreover, CryOVAlue investigates how the Spanish and Ukrainian ova banking industries are impacted by the war, and how they generate value within rapidly shifting regulatory regimes, markets, and state borders. This project is based on multi-sited ethnographic fieldwork, employing participatory observations in the ova banks and interviews with medical professionals, coor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ACTION PLAN TO SHAPE CORRIDORS AMONG DIHS TO FOSTER INNOVATION ECOSYSTEMS AND ACCELERATE THE DEPLOYMENT OF THE P4 MEDICINE PARADIGM' to be submitted under Horizon Europe.

assistant: **Abstract**

DIHs are one-stop-shops that help companies to become more competitive with regard to their business and production processes, products or services using digital technologies. DIHs have the mission of helping companies to betteDIHs are one-stop-shops that help companies to become more competitive with regard to their business and production processes, products or services using digital technologies. DIHs have the mission of helping companies (mainly start-ups, SMEs and mid-caps) to better understand and experiment on how digital technologies can improve their efficiency, effectiveness and product quality – in other words, their competitiveness. DIHs should have strong linkages with service providers outside of their own region in order to support companies in those services and technologies where regional DIHs do not have the requested in-house resources to provide services based on specific technologies sought by users. In recent decades, health-related activities have evolved from a reactive approach (curing diseases) to an approach based on the P4 medicine paradigm: Predictive, Preventive, Personalised and Participatory. In this new paradigm, the use of digital technologies is key. Thanks to digital technologies such as AI or HPC and the massive generation of medical and other health-related data, traditional methods for early detection, diagnosis, treatment, patient management, precision medicine, drug development, genomics, or medical image analysis are being transformed.DIHsP4_MEDICINE project aims to unleash the potential that exists around the collaboration among DIHs focused in health-related activities. The lessons to be learned from the activities carried out within the framework of the project will make possible to take advantage this experience for the impl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Anatomy and dynamics of the human replisome' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Accurately copying its whole genome is perhaps the most important task of the cell. Mistakes in DNA replication can result in cell death or, potentially worse, in mutagenesis and genomic instability, which in turn can lead to uncontrolled proliferation, the basis of cancer.  Elucidating the factors involved in DNA replication and understanding the mechanisms by which human cells guarantee the precise duplication of billions of base pairs and thereby appropriate proliferation are of utmost importance when aiming at defeating several diseases, among which cancer stands out as one of the leading causes of death in the world. While the actual enzymatic activity of DNA synthesis is accomplished by DNA polymerases, a remarkable set of extra factors is required for replication within the cell. Though the core replication components seem to be conserved from yeast to humans, in mammals the putative homologues of several key factors likely act with different mechanisms or have additional functions, as suggested by the low homology level and presence of extra domains. Thus, the object of my proposal is to identify novel factors involved in normal DNA replication progression and the response to replicative stress at the replisome level, specifically in human cells. I will put additional emphasis on elucidating the function of known metazoan-specific factors, which likely play a key role in the complex regulatory mechanisms required in higher organisms. To this end, I will combine various cutting edge methods, like nanobody-based sequential purifications, SILAC mass spectrometry and 3D-SIM microscopy, to develop assays to isolate active replisomes from human cells and study the identified factors mechanistically. This strategy will allow me to exploit and significantly expand my te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-order geometric derivatives with multilevel coupled cluster theory' (HOOD).

assistant: **Concept**

Spectroscopy involving molecular vibrations is an important class of experimental techniques, and accurate simulation tools based on computational quantum chemistry can greatly enhance our understanding and interpretation of the observed phenomena in these experiments. The most accurate quantum chemical methods are, however, very computationally expensive when applied to a full molecular system. Multilevel methods represent a promising approach for applying such accurate quantum chemical theory to calculate molecular properties for larger systems at a significantly reduced cost by concentrating the high-accuracy description to a limited part of the molecule. The goal of HOOD is to develop an efficient computational tool with multilevel capability for properties associated with molecular vibrations with coupled cluster as the underlying quantum chemical method. A novel tool will be applied for the derivation of so-called geometric derivatives which are fundamental in the evaluation of these vibrational properties. State-of-the-art software will provide the performance-optimized basic multilevel coupled cluster functionality upon which the HOOD feature can be built. Thanks to these tools, the complexity of the derivation and implementation processes – which constitute the core of this proposal – is significantly reduced, putting the goal within reach. The successful completion of HOOD will provide the scientific community with a state-of-the-art tool, uniquely facilitating high-accuracy studies of advanced vibrational spectroscopies and significantly expanding the range of systems for which these kind of studies can be undertaken.


**Keywords:** Vibrational spectroscopy, response theory, coupled cluster, geometric derivatives, multilevel approaches
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Philosophical Foundations of the Edge of the Universe' (EDGE).

assistant: **Concept**

The EDGE project is a philosophical study of the concept of an edge or boundary as it relates to the universe on the largest scale. But what does an edge refer to when the region is the entire universe? Despite widespread use of this boundary, there is little agreement about how to interpret it: some have called it “heuristic”; others “incoherent’; and still others a “law of nature”. There is no unified perspective on the general nature of boundary conditions in physics, and no agreed-upon conceptual foundation for how they apply to the entire universe.We propose an ambitious but credible programme to overcome this challenging problem. We begin with a classification of the properties, uses, and epistemology of boundaries as they are generally used in physics, from the separation of mind and world to the interaction of two coupled systems, and over a wide range of theories. We then turn to cases in which the boundary of the entire universe plays a substantial role in the frontiers of physics. These threads will form the basis for a general framework for understanding boundaries in physics, establishing shared features as well as the dimensions along which they differ. This will finally allow us to produce the first general analysis of what the edge of the universe means in physics: its ontology, its uses, and how we know about it.The pay-off of this project is a path-breaking new analysis in philosophy, which establishes a major new account of our universe at its farthest fringes. In physics, it stands to help clarify the pathway for those physicists actively developing the frontiers of science by using boundaries of this kind. More generally, it will establish a novel, accessible account of our place in the universe in comparison to the farthest reaches of our imaginati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Game theory and cooperation from economics to evolutionary biology' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

I will use game theory to study how ideas initially developed in economics can be applied to the problem of the evolution of cooperation in biology. Cooperation is usually explained by evolutionary theory by invoking iterations, which allow reciprocation, punishment or reputation effects; the prisoner’s dilemma has become the standard model to analyse these problems. However, there are other possible explanations and different, more appropriate theoretical models that can shed light on the problem. First, in a bilateral relationship in which one individual contracts another to carry out an action, setting the right costs and rewards of the interaction may lead the possible partners to screen themselves according to their own interest. Moreover, by making the reward conditional on the outcome of the effort, an individual can give an incentive to the partner to cooperate even in the absence of iterations. These two ideas are known in microeconomics as adverse selection and moral hazard. In the first part of my research I will develop similar models for evolutionary biology, analyse the differences of the assumptions and extend the models to cases of biological interest. Second, social dilemmas arising in N-person games can often be more properly described as a volunteer’s dilemma, in which if volunteering is costly, but so is failure to produce the public good, cheaters can invade and form a stable mixed equilibrium with cooperators. The dilemma is that the benefit for the group decreases with group size because the larger the group is, the less likely it is that someone volunteers. I will analyse this problem for cases in which individuals are related, more than one volunteer is needed and other specific assumptions. This will provide predictions that will be tested with