RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A global multi-institutional Typhoid fever genomic surveillance network to improve global public health outcomes' under Horizon 2020.

assistant: **Concept**

Globally there are ~20 million typhoid fever cases per year, resulting in ~200,000 deaths from infection with the causative agent, Salmonella Typhi. Antimicrobial therapy is the mainstay of typhoid fever control, and genomic epidemiology studies have revealed that drug resistance emerging in one country can rapidly spread to other neighbouring countries and intercontinentally. Genomic and phenotypic surveillance for typhoid and antimicrobial resistance (AMR) is therefore very important for disease control. TyphiNET aims to develop innovative approaches to bring the benefits of typhoid genomic surveillance to LMICs where the disease is endemic through three main goals: (1) to unlock data from travel-associated typhoid cases in high income countries that are adopting genomics for routine Salmonella surveillance (2) to unlock data from project-based genomic surveillance in endemic areas (beginning with five key collaborative projects across Asia and Africa) and (3) develop an open access publicly available platform for synergising, visualising, and disseminating large scale genomic data sourced from sentinel and endemic area surveillance.  Research questions will include inferring genomic epidemiology parameters (prevalence of strain types, resistance to specific antimicrobials, and regional transmission patterns) for different countries/regions using data from sentinel surveillance and from endemic area surveillance; comparison of these to demonstrate the utility of sentinel traveller surveillance for predicting endemic area disease patterns; and comparison of disease dynamics between regions. Outcomes will inform management of both endemic disease in LMICs and travel-associated cases elsewhere, including providing region- and country-specific data to inform empirical ant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Energy-specific solar radiation data from meteosat second generation (msg): the heliosat-3 project'.

assistant: **Objectives**

Objectives and problems to be solved:HELIOSAT-3 is to support the solar energy community in its efforts to in-crease the efficiency and cost-effectiveness of solar energy systems and to improve the acceptance of renewable. HELIOSAT-3 will supply high-quality solar radiation data gained from the exploitation of advanced Earth observation technologies. A substantial improvement of data quality is expected and this should better match the needs of the companies and other customers of the resulting products. HELIOSAT-3 results will be integrated into the follow-ups of the projects Satel-Light, PVSAT, SolarGIS, European Solar Radiation Atlas, and Soda. Description of work: HELIOSAT-3 will establish a prototype service for retrieving surface solar irradiance and derived energy-specific quantities taking advantage of the enhanced capabilities of the new Meteosat Second Generation (MSG) satellites. The main components of HELIOSAT-3 are: · Retrieval algorithms for the MSG-based estimation of major atmospheric parameters modifying the radiative transfer: water vapour, aerosols, ozone, and clouds· Calculation schemes for(i) solar irradiance based on MSG data and the retrieved actual atmospheric parameters and(ii) additional parameters relevant for solar energy applications (direct normal and spectral irradiance, angular distribution of diffuse irradiance, spatial structure of irradiance)· Implementation of an operational processing chain from Meteosat data to end-use oriented solar radiation data· Comprehensive validation with data resulting from ground measurements and current satellite methods· Prototype applications assessing the economic benefit of the derived products for the solar energy sector. The implementation of HELIOSAT-3 on a routine basis at two partners' sites will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Satellite switching and end-to-end trial' to be submitted under Fourth Framework.

assistant: **Abstract**

Main ObjectiveASSET's main aim is to validate, both theoretically and experimentally, the EuroSkyWay (ESW) system design concepts, with primary focus on the (i) network end-to-end performance, (ii) broadband traffic and mobility management, and (iii) on board switching architecture. The validation approach is based on a comprehensive end-to-end system demonstrator which includes all cumulative effects on both fixed and mobile channels, and the complete set of communication layers. This should allow the evaluation of the offered GoS in a pre-operative environment and shorten the time to market for a European broadband satellite network together with its key elements.Technical ApproachThe project consists of two phases devoted to: (i) study the basic system consolidation; (ii) demonstrate the capabilities of the end-user terminal, on-board regenerator prototype (space qualified) and the overall end-to-end system. The study phase addresses the specification and design of the ESW network by providing the analysis and rationale for choosing the system parameter values, and conducting simulation modelling of the satellite and terrestrial sections to predict quantitatively the network GoS for different traffic scenarios. The requirements and design of a multi-Gigabit on-board intelligent switch, with capability to route single cells from the input carrier to the destination carrier under the control of the on board Traffic Resource Manager which assigns and releases band on demand, will be assessed. In addition, the critical procedures for the management and control of end-to-end connections over multi-satellite, multi-protocol systems supporting user and terminal mobility will be evaluated.The demonstration phase addresses the end-to-end system capabilities providing quantita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Harmonisation of standards and regulations for a sustainable hydrogen and fuel cell technology', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

HarmonHy aims first to make an assessment of the activities on hydrogen and fuel cell related regulations and standards on a worldwide level. On this basis gaps will be identified and propositions to solve fragmentation will be made. Potential conflicts b etween codes, standards and regulations will also be investigated and propositions to solve the conflicts will be made. Particular attention to identify the needs for standards as perceived by the industry will be paid as well as action to ensure concord ance between standards and regulations. The final goal of all the process is to render European collaboration in the field as effective as possible and to increase its contribution at the worldwide level, rendering it more effective and homogeneous as w ell as corresponding to its major interests. At a second stage, the result of the discussions could also serve as basis for further projects to be set up as response to the last call series of FP6. As a conclusion to the different discussion meetings and hearings the partners intend to organise as final point of the SSA a conference with the aim to present the results of the project and guidelines for the setting up of adequate bodies to solve the identified problems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Learner language' to be submitted under Fifth Framework.

assistant: **Abstract**

The overall goals of these two conferences are to attain a better understanding of second language acquisition after childhood, and in so doing, to contribute original insights to our understanding of the human language capacity. Two EURESCO conferences (1996 & 98) organised on the topic have gone some way towards achieving these goals, and it is intended to consolidate this effort. The previous meetings analysed empirical findings for the acquisition of a number of European languages, and a consensus emerged as to what the relevant descriptive generalisations over second acquisition (SLA) are. A strong motivation for proposing two further meetings is that there is much less consensus on the relative importance to be given to different theoretical explanations for second language acquisition. Now is a very timely opportunity, after three decades of intensive and largely European empirical research, to test the explanatory power of different theoretical approaches on agreed, and crucial, sets of data and, furthermore, to test the generality of the SLA results by asking outside experts to critically discuss them. On a more concrete level, this involves building a platform where European second language acquisition research findings can also be discussed by theoretical linguists, experimental psycholinguists and first-language acquisition researchers. Such an interdisciplinary approach is essential to the enterprise, and provides, moreover, an ideal context for young researchers to appreciate the broader questions facing the linguistic sciences (see Training Content).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Investigating Translation and Metabolism in mTORC2-driven Cancer'.

assistant: **Concept**

The aim of this project to investigate the role(s) of mTORC2 in mRNA translation and cellular metabolism, in the context of lung cancer development. This work will be carried out in the laboratory of Dr. Pierre Close, at the GIGA-Uliège, who made seminal discoveries in the field of translation regulation and cancer biology. This ambitious project will bring an opportunistic synergy between the expertise in cancer metabolism of the researcher, Dr. Blomme, and the knowhow in translation regulation of the host laboratory. In addition, the project relies on the combination of cutting-edge unbiased “omics” approaches and involves the characterisation of unique mouse models recently generated in the host lab. It is further supported by four high-profile international collaborations that will provide essential technical expertise in metabolomics and lipidomics, and support the clinical aspects of the proposal. As part of an interdisciplinary training, Dr. Blomme will carry out a secondment in the translational research group of Prof. Vooijs, at Maastricht University, in order to learn ex-vivo organoid models of lung cancer. The proposed project addresses fundamental questions of cell biology in a highly clinically relevant context. As such, it holds the potential to result in the design of future anticancer therapeutic strategies. Indeed, the mTORC2 pathway is very often dysregulated in lung cancer. Therefore, by deciphering the molecular mechanisms that sustain mTORC2-dependent metabolism, this work will provide innovative strategies to target mTORC2 signalling in lung cancer.


**Keywords:** Cancer metabolism, mRNA translation, mTORC2 signalling, lung cancer, mouse models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New hope for the PAH patient: A Novel Therapeutic for Pulmonary Arterial Hypertension (PAH)' (PAH) under Horizon 2020.

assistant: **Objectives**

ATXA Therapeutics Ltd is a company on a mission to offer new hope to patients with pulmonary arterial hypertension (PAH). PAH is a debilitating lung & heart disease with an urgent need for new medicines targeting different pathways than current drugs. These drugs do not effectively treat the disease, they carry serious side-effects, are poorly tolerated and only extend life-expectancy from 2.8 years (untreated) to 3.6 years (treated). ATXA has developed novel therapeutic drugs to treat PAH. ATXA’s drug target is the human Thromboxane Receptor, a pathway involved in all the clinical features of PAH. Based on evaluations in 2 independent animal models of PAH, ATXA’s lead NTP42 is predicted to be a truly disruptive disease-modifying drug, treating all aspects of PAH and greatly extending life expectancy. ATXA has completed the preclinical phase of its drug development program and has secured orphan designation from the EMA and FDA regulatory agencies for NTP42 for PAH treatment. The objective of PAH-HOPE is to advance ATXA’s drug NTP42 into clinical development, starting from scaled up drug manufacture through to securing regulatory clinical trial authorization (CTA).  Securement of CTA will position ATXA to advance NTP42 to Phase I-III clinical trials through to marketing authorization and product launch in 2025.  ATXA’s NTP42 fits with the current focus on value-based healthcare delivery, resulting in improved healthcare outcomes that matter to patients, physicians, payors but at lower cost of delivery. ATXA’s ambition is that NTP42 will capture 15% share of the lucrative PAH market resulting in $700m revenue within five years following global commercialization, growing to a mid-size SME with 155 employees. ATXA has 8 granted patents protecting NTP42 out to 2033 and beyo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'RADIOGENOMICS: Finding Genetic Functional Variants Through Fine Mapping'.

assistant: **Objectives**

“Radiogenomics” is the study of the genetics of toxicity following radiotherapy. Unintended damage to normal tissues can severely affect up to 5% of patients for years after completion of curative cancer radiotherapy. To date three Genome Wide Association Studies on radiation toxicity in prostate cancer patients have been performed. These studies have identified genetic loci associated with development of radiation-induced toxicity phenotypes in local tissues. To increase the very limited power of each independent study, the three groups are collaborating on a meta-analysis of harmonised toxicity phenotypes (nocturia, urinary frequency, decreased stream and proctitis) and have identified several promising new loci. The proposed activity at the Centre for Cancer Genetic Epidemiology will be fine-scale mapping of these loci identified with the aim of identifying the genetic variants directly responsible for these toxicity phenotypes. The objectives of the proposed research are: 1. For the Researcher to learn advanced genetic epidemiological and fine-mapping skills by participating in team-based analysis of incoming massive, “OncoArray” datasets – which will be analysed at the host institution; 2. Identify and validate additional novel genetic radiation toxicity loci through analysis of specific radiotoxicity SNP-sets on the “Oncoarray” and through additional GWAS meta-analysis; 3. Apply high-level skills, gained in objective 1, to the fine scale mapping of radiation toxicity loci with the aim of to identifying the top genetic causal candidate variants for radiation toxicity; 4. Carry out bioinformatic functional analysis of the top causal candidates to both narrow the candidate list further, and gain understanding of the molecular patho-physiology and genetic mechanisms t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Paradise Unexplored: Biodiversity of the Seven Sister States of North East India'.

assistant: **Objectives**

Biodiversity is unevenly distributed in space and time, and biologists seek to explain the generalities and exceptions. North East India (NEI) is very rich in biodiversity. Previously this was thought to be because it is a gateway between the Himalaya and IndoBurma regions. These two latter regions are considered biodiversity conservation hotspots, with the boundary between them running through NEI.It was a major surprise therefore when the applicant discovered and named a new family of amphibians (Chikilidae) that is endemic to NEI, has been evolving here for 10s of millions of years, and has its closest living relatives in Africa. This newly discovered major lineage has demanded i) that the new family is thoroughly characterized and understood in the broader context of amphibian evolution, ii) that the generality of the historical biogeography of Chikilidae is tested using independent but broadly similar lineages, and iii) that the environmental and biological history of NEI is reassessed, especially the implications for recognising biogeographic units and demarcating hotspots.The applicant will address these issues by a) analysing the internal anatomy, life-history, distribution and genetic variation of Chikilidae in a comparative context, b) inferring the phylogeny and biogeographic history of two other soil-dwelling vertebrates with overlapping distributions – ichthyophiid amphibians and swamp eels, and c) determining to what extent the two lineages resemble Chikilidae in having radiated in NEI for a long period.The applicant is a world expert on NEI and Indian amphibians. The hosts run the world’s leading caecilian biology research group. The host institution has state-of-the-art facilities (specimen collections, genetics, morphological imaging labs) and several e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-protein interaction kinetics by single molecule methods' under Horizon 2020.

assistant: **Concept**

Objective of this proposal is to obtain a real time picture of how components of a multi-protein complex interact to perform complex regulated tasks, in particular to see how a protein system might be more than the sum of its components. In living organisms many proteins work in complexes to form multicomponent protein machines and to regulate cellular processes. The function of such multicomponent machines is usually addressed by dividing them into a collection of two state systems at equilibrium. Many molecular machines work in large complexes with multiple states out of equilibrium by utilizing the energy of ATP hydrolysis. In this proposal the real time kinetics of multi-protein interactions in and out of equilibrium will be investigated using single molecule methods. The succession of association and dissociation steps as well as large conformational changes within the proteins will be monitored simultaneously with multicolour single molecule FRET in real time. In order to observe at the same time the folding state of proteins, a combination of optical tweezers and single molecule FRET will be developed. Finally, a combination of microfluidics for fast mixing and single pair FRET will be developed to investigate interactions of low affinity. A large part of the experiments will focus on the example of the heat shock protein Hsp90 system, which consists of co-chaperones, clients and nucleotides. Altogether, these interdisciplinary experiments will yield unprecedented information on multi-component interactions in equilibrium and out of equilibrium on timescales from sub milliseconds to hours. I am confident that these studies will have an impact on the understanding of the Hsp90 machinery as well as general principles of multi-component protein systems, which is the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Planning the european research area in metrology (MERA)'.

assistant: **Concept**

The aim of this Initiative is to increase significantly the impact of European research effort by strengthening the coherence of national and EU funded research activities and policies conducted in Europe. This proposal will lay the foundations for such an European Research Area in the field of Metrology. Innovation is often dependant on good measurement. A coherent European approach to metrology research will facilitate scientific and technological growth and competitiveness in Europe. This activity will include a review of current collaboration in Europe, identification of research trends, an examination of the scenarios for the structure of metrology research in Europe, the development of decisions making tools, a workshop to examine the issues and disseminate the tools , an analysis at national level and a second workshop delivering a plan for the implementation of an ERA in MetrCilogy in the sixth FP.