RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Seamless mixing of virtual & real-world objects in VR & AR' (LIGHTFIELD) targeting Horizon 2020.

assistant: **Abstract**

Despite recent major technological progress (e.g. with Oculus Quest), virtual or augmented reality headsets today have not yet entered mass adoption. One of the reasons for that is the discomfort, eyestrain and sometimes physical pain after prolonged use that they cause to some of the users. To perceive depth, the human eye needs to change focus between objects in different distances. This is impossible in today’s devices based on flat screen technology. The mismatch between binocular depth and focus (vergence-accommodation conflict) causes eyestrain, pain, and nausea for users. It is a serious problem in VR, but it is a true showstopper in the AR where our eyes see both real and virtual objects at the same time. Our patented light-field technology generates truly 3D hologram-like images. It solves the eyestrain and pain problems of current headsets, while increasing immersion of users and allowing conflictless mixing of virtual and real worlds. Our company’s mission is to resolve the key problem blocking widespread adoption of virtual and augmented reality by developing near-eye light-field technology. Our technology fully replicates human perception of 3D images with optical depth. Our ultimate goal is to provide the key technology for the next generation of wearable products– smart glasses, which could supplement or even eventually replace the current smartphone. We are currently offering VR and AR development kits (prototypes) of the light-field display and associated rendering software to our clients to initiate pilot and integration projects. So far, our company was financed by own funds, start-up competitions, and prize money of €240,000 in total, proof of concept project with Samsung Mobile of €50,000, and a seed round of €780,000. We plan to raise €4.6m in Seri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Archaeometric investigation of ancient glass – identification of the sources of Cu, Sb and Ti via isotopic analysis using (laser ablation) multi-collector  ICP – mass spectrometry""' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

As a first approximation, the isotopic compositions of the elements can be considered as constant in nature. However, small variations do occur and isotopic analysis of the elements showing such variations can provide very valuable information in several domains of science, e.g., archaeometry, forensics or environmental research.Whereas isotope ratio mass spectrometry (IRMS) is traditionally used to investigate the isotopic composition of light elements, for a long time, thermal ionization mass spectrometry (TIMS) was the only technique providing sufficient precision (RSD = 0.005%) to detect slight variations in the isotopic composition of the heavier elements. Nowadays, multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS) is an even more powerful tool for highly precise isotope ratio determination as it provides information on the small variations (often  1‰) shown by some elements that are not or hardly accessible by means of TIMS (e.g., elements with high ionization potential) and, therefore, the importance of MC-ICPMS is currently growing, also in the field of provenance determination.The main goals of this research project will be the development of analytical methods for measuring the isotopic composition of Cu (colorizer), Sb (decolorizer) and Ti (introduced via sand) in glass and subsequent use of the methods developed for provenance determination of ancient glass objects.  First, optimization studies will be performed using conventional solution nebulization as a means of sample introduction. The work will comprise the development of isolation methods for each of the target elements, as well as the validation of the methodology proposed in terms of analyte purity, recovery and absence of fractionation. In a second phase, it will be evaluated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Laughing in an Emergency: Humour, Cultural Resilience and Contemporary Art'.

assistant: **Objectives**

In the wake of the Charlie Hebdo attacks in 2015, humour has been regarded as serious, incendiary, and potentially fatal business. A curious phenomenon has simultaneously occurred in contemporary art, as artists located around the world have turned to humorous aesthetic strategies in order to document and re-assess global politics, experiences of crisis and collective trauma. In spite of this turn, and although the politics of humour has attracted recent attention, leading scholars across the social sciences and humanities continually lament the lack of scholarly analysis on the subject. In this context, the main objectives of LIAE are 1) to develop a conceptual framework and gather empirical information to account for the impetus behind the emergence of humour in art from contemporary sites of ‘crisis’; 2) to develop a novel framework of how humour advances the social function of art by operating as a vital agent of cultural resilience in three keys ways: re-enforcing connection to place, coalescing collective identity, and by subverting oppressive authority structures; 3) to develop a conceptual framework that accounts for how ‘high art’ settings radically differs to that of ‘viral’ or ‘demotic’ forms (cartoons, memes and street art). To achieve this, LIAE is informed by a comparative study of 3 key case studies, each legislatively recognized as sites of crisis, and each emblematic of particular forms of contemporary ‘emergency’: economic/refugee crisis (Greece), indigenous sovereignty/endemic disadvantage (Australia) and military conflict/occupation (Palestine). Employing an adaptive form of visual culture research (discourse analysis, fieldwork, in-situ visual analysis, archival and primary research) refined through a training program and expert supervision at UNIMA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DNA Damage Response-instructed Macrophage Differentiation in Granulomatous Diseases' in the context of a Horizon 2020 call.

assistant: **Objectives**

Macrophage differentiation programs are critical for the outcome of immunity against infection, chronic inflammatory diseases and cancer. How diverse inflammatory signals are translated to macrophage programs in the large range of human pathologies is largely unexplored. In the last years we focused on macrophage differentiation in granulomatous diseases. These affect millions worldwide, including young adults and children and tend to run a chronic course, with a high socioeconomic burden. Their common hallmark is the formation of granulomas, macrophage-driven structures of organized inflammation that replace healthy tissue. We revealed that macrophage precursors in granulomas experience a replication block and trigger the DNA Damage Response (DDR), a fundamental cellular process activated in response to genotoxic stress. This leads to the formation of multinucleated macrophages with tissue-remodelling signatures (Herrtwich, Cell 2016). Our work unravelled an intriguing link between genotoxic stress and granuloma-specific macrophage programs. The molecular pathways regulating DDR-driven macrophage differentiation and their role in chronic inflammatory pathologies remain however a black box. We hypothesize that the DDR promotes macrophage reprogramming to inflammation-maintaining modules. Such programs operate in granulomatous diseases and in chronic arthritis.  Using state-of-the art genetic models, human tissues and an array of techniques crossing the fields of immunology, cell biology and cancer biology, our goal is to unravel the macrophage-specific response to genotoxic stress as an essential regulator of chronic inflammation-induced pathologies. The anticipated results will provide the scientific community with new knowledge on the role of genotoxic stress in immun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safety Enables Cooperation in Uncertain Robotic Environments' (SECURE) under Horizon 2020.

assistant: **Objectives**

The majority of existing robots in industry are pre-programmed robots working in safety zones, with visual or auditory warning signals and little concept of intelligent safety awareness necessary for dynamic and unpredictable human or domestic environments. In the future, novel cognitive robotic companions will be developed, ranging from service robots to humanoid robots, which should be able to learn from users and adapt to open dynamic contexts. The development of such robot companions will lead to new challenges for human-robot cooperation and safety, going well beyond the current state of the art. Therefore, the SECURE project aims to train a new generation of researchers on safe cognitive robot concepts for human work and living spaces on the most advanced humanoid robot platforms available in Europe. The fellows will be trained through an innovative concept of project-based learning and constructivist learning in supervised peer networks where they will gain experience from an intersectoral programme involving universities, research institutes, large and SME companies from public and private sectors. The training domain will integrate multidisciplinary concepts from the fields of cognitive human-robot interaction, computer science and intelligent robotics where a new approach of integrating principles of embodiment, situation and interaction will be pursued to address future challenges for safe human-robot environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Uncovering the Role of X Chromsome Inactivation Escapees in T Cell Function' in the context of a Horizon Europe call.

assistant: **Objectives**

Sex differences play a significant role in immune function, with women generally mounting stronger immune responses than men. A key factor behind these differences is the X chromosome, which contains many genes that are important for immune function. In females, who have two X chromosomes, one of the X chromosomes is usually inactivated in each cell to prevent an overdose of X-linked gene expression. This process is known as X-chromosome inactivation (XCI). However, some genes can escape this inactivation and are expressed from both X chromosomes. These escapee genes are often expressed at higher levels in females than in males, who only have one X chromosome. The X-CITE (X-Chromosome Inactivation and T cell Escape) project aims to elucidate the molecular mechanisms by which these XCI escapee genes influence T cell responses. Understanding these mechanisms is crucial, as T cells are central to the success of cancer immunotherapy, where sex-based differences in T cell function may impact treatment outcomes. By exploring the sex-biased expression of XCI escapee genes, this project will advance our understanding of sex differences in immune responses and provide new insights into how T cells can be manipulated to improve the efficacy of cancer immunotherapy. The research will be conducted at the Landsteiner Laboratory Amsterdam UMC-Sanquin (The Netherlands), under the supervision of Dr. Monika Wolkers, whose lab specializes in T cell biology and the enhancement of T cell functions in immunotherapy settings.


**Keywords:** X-Chromosome Inactivation (XCI), T cells, Immunotherapy, Sex, Single-Cell Sequencing, Gene Regulatory Networks (GRN)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Arctic Health Risks: Impacts on health in the Arctic and Europe owing to climate-induced changes in contaminant cycling'.

assistant: **Innovation**

Long-range transport of contaminants to the Arctic, the resulting exposures observed in Arctic human populations, and impacts of such exposures on human health have been the subject of considerable work in recent years, providing a baseline against which to compare future developments. Global climate change has the potential to remobilize environmental contaminants and alter contaminant transport pathways, fate, and routes of exposure in human populations. The Arctic is particularly sensitive to climate change and already exhibits clear impacts. Research into contaminant exposure and its effects on human health in the Arctic, in comparison with other exposed populations in Europe, presents an opportunity to gain insight into changes that may later impact other areas. The influence of climate change on contaminant spreading and transfer and the resultant risk to human populations in the Arctic and other areas of Europe will be studied by: 1) Research on the ways in which climate change will affect the long-range transport and fate of selected groups of contaminants, and possible implications for the re-distribution of contaminants (geographically and between relevant environmental media). This will involve modelling, utilizing the information base that exists on the distribution of such contaminants in the Arctic and other areas of Europe; 2) Research on the impacts that changing pathways and climatic conditions will have on contaminant uptake and transfer within food webs, leading to foods consumed by humans. This will involve experimental work, process studies and targeted analytical studies, the latter focussed on supporting the modelling work and process studies related to human exposure to contaminants;  3) Research focussing on human health, aimed at determining ho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The role of microRNAs in the Retinal Bipolar Cell'.

assistant: **Innovation**

Studies conducted at the Friedrich Meischer Institute (FMI) in Basel have focused on the roles of miRNAs specific to the retina. They have recently shown that absence of functional miRNA expression has severe consequences on mature cone photoreceptors of the mouse retina; a selective and dramatic reduction of cone-specific gene expression arises with the cone-specific loss of regulation by miRNAs in adult mice. The bipolar cells act post-synaptically to the photoreceptors where they not only transmit but also process the light signal received from rods and cones. In this proposal I wish to examine whether absence of functional miRNAs have as severe implications for the bipolar cells as they do for cone photoreceptors. In addition by profiling the miRNA population of these highly specialised neurons I hope to uncover miRNA/mRNA interactions that can fine-tune synaptic transmission and thus contribute to visual processing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'integrated nano-photonic OMICs bio-SENSor for lung cancer' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

OMICSENS aims to develop a radically new omics measurement platform that would be initially applied to improve non-small cell lung cancer (NSCLC) prognosis by ensuring a timely and accurate detection of Tyrosine Kinase Inhibitor (TKI) resistance associated to Epidermal Growth Factor Receptor (EGFR) mutations. Subsequently, OMICSENS will be used to improve prognosis of patients suffering from other types of cancers. OMICSENS targets the creation of the first nano-photonic integrated omics bio-sensor to tackle TKI resistance and improve NSCLC treatment outcome and patient prognosis. Thanks to OMICSENS, we will build a six layers technology comprised of an on-chip embedded infra-red source arrays, an artificial intelligence optimized nano-structured surface for photonic signal enhancement, a functionalized surface of high absorbance to specific analytes, a microfluidics system to deliver the sample, a metamaterial-based photo detector array with optimized quantum efficiency and an AI algorithm enabling analyte quantification. Our miniaturized omics bio-sensor will enable real time and concurrent measurements of omics, compatible with organ-on-chip (OOC) in the future. OOC is one of the most promising bioengineering developments, paving the way to more efficient drug testing and personalized medicine trough digital twinning of a biological system. But OOC is lacking a real-time, integrated bio-sensing technology. OMICSENS proposes a disruptive bio-sensor to bridge this gap. OMICSENS will create a radically new device useful for telehealth, capable of improving medical diagnostics, while fostering a patient-centered approach. To achieve our novel and ambitious objective, we have brought together an interdisciplinary consortium of top-level academics (LMU, UNITN, IBEC, KTH) a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enhanced substrates and GaN pilot lines enabling compact power applications' in the context of a Horizon 2020 call.

assistant: **Objectives**

The key objective of PowerBase “Enhanced substrates and GaN pilot lines enabling compact power applications” is to ensure the availability of Electronic Components and Systems (ECS) for key markets and for addressing societal challenges, aiming at keeping Europe at the forefront of the technology development, bridging the gap between research and exploitation, creating economic and employment growth in the European Union. The project PowerBase aims to contribute to the industrial ambition of value creation in Europe and fully supports this vision by addressing key topics of ECSEL multi annual strategic plan 2014. By positioning PowerBase as innovation action a clear focus on exploitation of the expected result is primary goal.To expand the limits in current power semiconductor technologies the project focuses on setting up a qualified wide band gap GaN technology Pilot line, on expanding the limits of today’s silicon based substrate materials for power semiconductors, improving manufacturing efficiency by innovative automation, setting up of a GaN compatible chip embedding pilot line and demonstrating innovation potential in leading compact power application domains.PowerBase is a project proposal with a vertical supply chain involved with contributions from partners in 7 European countries. This spans expertise from raw material research, process innovation, pilot line, assembly innovation and pilot line up to various application domains representing enhanced smart systems. The supporting partners consist of market leaders in their domain, having excellent technological background, which are fully committed to achieve the very challenging project goals.The project PowerBase aims to have significant impact on mart regions. High tech jobs in the area of semiconductor tec