RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Strongly Polarized Carbon: Taming Fundamental  Intermediates and Their Applications' to be submitted under Horizon Europe.

assistant: **Abstract**

In CC-CHARGED, I propose a new concept to induce C–C bond polarization as well as predict fundamentally new stable carbon-based compound classes. The manipulation of functional groups builds the basis for the rational design of complex molecules in organic synthesis. While most compound classes have been studied for decades, few remain virtually unexplored, only suggested as reactive intermediates. I propose to tame these elusive intermediates into hitherto unknown room-temperature stable compound classes. Central motif to gain stability relies in the polarization of the C–C bond, which can either result in zwitterions (charged +/-) or diradicals. The dichotomic behavior will be analyzed and a general approach to C–C bond polarization will be developed based on a new concept of mesoionic frustration. Such mesoions are predicted to be exceptionally strong polarized carbon compounds, exceeding the polarization of traditional ylides, triggering applications from transition metal, main group chemistry to organic synthesis. The reactivity of such strong carbon donors will be analyzed, correlated and a scale generated. Applications of C–C bond polarization in the stabilization of unsaturated diazo and monosubstituted carbon compounds are presented. Their synthesis, electronic structure and reactivity will be evaluated and applications such as C-atom transfer reagents for molecular editing studied. While singlet vinylidenes are central intermediates in organic reactions, the generation and reactivity of triplet vinylidenes is virtually unknown. I propose them as new compounds in organic chemistry, as metal-vinylidene precursors and as new platforms for magnetic applications. Recent high-impact publications by the group build the basis for this project that goes far beyond the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Maskless Surface morphing by Holographic Hyper Lithography' (HyperMaSH), addressing dissemination and exploitation.

assistant: **Impact**

Photonics, the science of harnessing light, has the potential to revolutionize many sectors of the society. The envisioned transition from electronics to photonic technologies requires advanced and miniaturized optical devices. Planar optical components, realized as micro- and nanoscale structured surfaces, are at the forefront of this transition. However, their fabrication by traditional methods is still a barrier to their widespread use in applications. A photolithographic process that fully exploits the multiple degrees of freedom of the light is part of the solution. HyperMaSH will introduce a radically new concept for surface photopatterning of advanced planar optical components: the Vector-Time-Color Hyper Lithography. I will define a multi-dimensional space of lithographic parameters, where the intensity pattern, the polarization distribution, the time evolution, and the wavelength of a holographic light field are simultaneously and synergically engineered.For HyperMaSH’s approach, I will leverage the peculiar vectorial and reversible photoresponse of azobenzene-containing materials in combination with Jones matrix holography and digital holographic microscopy. The result will be the dynamical and reversible manipulation of the surface morphology on micro and nano spatial scale. Operating diffractive optical components and metasurfaces will be directly produced without any of the post-exposure processes of the standard photolithography.  I will realize a paradigm shift by developing an unprecedented direct and high-resolution patterning method with significantly reduced environmental impact and energy consumption. Results will have far-reaching implications beyond the fabrication of planar optical components to be used either directly or as reusable masters for s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Transfer of knowledge towards a world class combustion chemistry centre'.

assistant: **Objectives**

This project brings together scientists and engineers with the requisite expertise to enhance the capabilities of a combustion chemistry group so that this transfer of knowledge will allow the creation of a world-class centre dedicated to the reliable prediction of combustion events from a chemical perspective. This objective requires a fundamental understanding and a capacity for modelling both the underlying chemistry and combustion environments.In general the modelling/simulation of combustion can involve complex mixtures (a typical petrol may contain over 300 compounds), complex reactions (a reasonable description of the reaction between hydrogen and oxygen demands 19 individual elementary steps; that between n-decane and oxygen needs 7,920), complex reactors (an internal combustion engine is characterised by a complicated three-dimensional geometry, rapidly changing temperatures and pressures, turbulent flows, valves opening and closing, etc.) and complex data; in other words, the modelling of complexity.Much of the required input data, such as reaction rate constants, is simply unavailable or extremely time consuming to measure. Our research group has unique laboratory equipment for studying the chemistry of oxidation at both high and medium temperatures, and, key skills in detailed chemical kinetic modelling, but, it lacks three important ingredients required to translate this expertise into a coherent package.These key skills are:- the quantum mechanical computation of transition states and the thermochemistry of both stable and free-radical species to chemical accuracy, and, the calculation of reaction rates by canonical variational transitionstate theory,- the ability to generate mechanisms automatically via logical programming or computer-aided design, and,-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Stress, Prefrontal function and Cognition: Role of the Glucocorticoid Receptor'.

assistant: **Concept**

Cognitive deficits are hallmark features of a variety of psychiatric diseases. While body of evidences pointed to the prefrontal cortex (PFC) as a key structure for cognition, recent studies further suggested that abnormalities in the interaction between inhibitory interneurons and glutamatergic pyramidal cells within PFC microcircuit could be involved in the pathogenesis of cognitive deficits in psychiatric disorders. Thus, intensive effort has been made to understand the mechanisms underlying PFC microcircuit dysfunction and the ensuing cognitive impairment. Stress-induced release of glucocorticoids (GCs) has been associated with cognitive symptoms in multiple mental disorders. GCs modulate behavioral responses to stress via their binding to the glucocorticoid receptor (GR), a nuclear receptor expressed in heterogeneous cell populations throughout the brain. Although it has been suggested that GCs could alter cognition through their action within the PFC, it is still unknown whether and how the GCs via their action on distinct cell types within the PFC can alter cognition, prefrontal microcircuit function and larger brain circuits. Only a genetic approach offering spatial resolution and cell-type specificity can precisely address these issues. Given their key role in cognition and their potential involvement in the pathophysiology of psychiatric disorders, I propose to manipulate GR expression within PFC pyramidal neurons and Parvalbumin-expressing interneurons. Using a battery of PFC-dependant cognitive tasks, I will study the behavioral consequences of these manipulations. Finally, combining whole cell patch-clamp and in vivo multisite recordings in behaving mice, I will assess the functional impact of GR gene manipulation on PFC microcircuit and hippocampo-frontal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CHARLES University Programme for Sustainable Goals, Training, Openness and Novelty in Research' (CHARLESTON).

assistant: **Concept**

Charleston stands for CHARLES University Programme for Sustainable Goals, Training, Openness and Novelty in Research. It's a unique opportunity, inviting 20 exceptional postdoctoral researchers from any nationality, provided they meet the MSCA mobility condition and have a doctoral degree with up to eight years of research experience.Central to the programme are three key objectives: fostering progress towards the United Nations Sustainable Development Goals (SDGs), enhancing support for postdoctoral career advancement, and offering fellows enriching intersectoral experiences. Charleston stands out for its merit-based selection process, overseen by independent evaluators in line with Charles University's commitment to equal opportunities.As a mono-beneficiary project, Charles University not only administers but also directly benefits from this programme, hosting research across its 21 diverse faculties and departments. The heart of Charleston lies in its robust 24-month fellowship at Charles University, supplemented by a mandatory three to six months of practical experience in non-academic settings. This structure is deliberately designed to stimulate curiosity-driven research across various scientific fields, closely tied to the SDGs.More than just a funding mechanism, Charleston is a holistic journey in postdoctoral career, involving a network of partners for hosting, training, and broad dissemination of research findings. It also provides its fellows with competitive remuneration, including mobility and family allowances, underscoring its dedication to supporting researchers both professionally and personally.


**Keywords:** postdoctoral, postdoc, career development, charles university, sdgs, inter-sectoral,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SEcurity CRitical applications based in open source InternET protocolS', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective of the SECRETS project is to evaluate the use of open source security protocols in distinct industrial applications in terms of appropriateness, reliability, performance, portability and openness. The project will evaluate the Open SSL and IPSec freeware security protocols in the areas of e-commerce, mobile applications (WAP, GPRS) and telecommunications, thus covering a broad scope of industrial needs. The IPSec and the OpenSSL protocols provide the sufficient ground for technical viability and interoperability. The expected outcome of the project will be to further strengthen the use of open source security protocols, the promotion of the relative standards and the market position of the partners involved. The foremost advantage is that a European evaluation - solution covering different market areas will be accomplished to offer strong security means in a fully controllable manner to European companies.Objectives:To evaluate the suitability of the open source SSL and IPSec protocols in respect to the user authentication, data integrity and data encryption over different type of networks. To evaluate the appropriateness of the open source security protocols in terms of performance and reliability over different types of industrial applications. To evaluate the performance of the open source software security mechanisms over mobile network configurations and mobile terminals for WAP/GPRS applications. To propose potential enhancements on the selected freeware protocols in order to be safer, faster and provide security services customised to high-end applications. To conduct four distinct Best Practice experiments in the areas of e-commerce, mobile communications, VoIP applications and Intelligent Networks applications and to provide a roadmap for the util
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nanoscale Aromaticity and Supramolecular Electronic Materials' in the context of a Horizon 2020 call.

assistant: **Objectives**

ARO-MAT will target emergent cooperative electronic and magnetic phenomena in molecules with dimensions of 5–25 nm (i.e. as big as many proteins). The project will develop supramolecular architectures with large pi-systems and well-defined geometries, in which the frontier orbitals coherently delocalize charge over the whole nanostructure. Aromaticity is a key emergent phenomenon; it can be defined as the ability of a cyclic molecule to sustain a ring current when placed in a magnetic field. Until recently, it was thought that aromaticity is restricted to small molecules, with circuits of less than about 22 pi-electrons. Anderson has shown that circuits of more than 160 pi-electrons (circumference > 15 nm) can exhibit strong aromatic ring currents. Testing even larger rings will elucidate the link between aromaticity and the persistent currents found in non-molecular mesoscopic rings (diameter 50–500 nm). ARO-MAT will explore the effects of molecular size and topology on nanoscale aromaticity. Other emergent phenomena to be addressed include the formation of open-shell singlet polyradical ground states, magnetic bistability in systems with many paramagnetic metal centers, and the control of charge transport through single-molecule devices by quantum interference. This multidisciplinary project combines organic synthesis, supramolecular chemistry, theory, electronic structure calculations, NMR and EPR spectroscopy, magnetochemistry, molecular electronics and low-temperature charge transport experiments. The core objective is to create low band gap materials with unprecedented electronic and magnetic properties, and to understand the structure-property relationships governing the behavior of these new materials. Most of the target structures are based on metalloporphyrins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation' under Horizon 2020.

assistant: **Concept**

Enzymatic cascades open a path to the efficient implementation of complex biotransformations for producing from high-cost pharmaceuticals to low-cost biocommodities. However, for multi-step synthetic schemes catalyzed by incompatible or unpaired enzymatic cascades, efficient cell-free one-pot systems, where enzymes are perfectly orchestrated and regulated, have yet to be developed.  In HOTZYMES, we propose to develop a new ground-breaking concept to exert functional control over different enzymes using magnetic heating. We expect to control enzyme activity by conjugating enzymes and magnetic nanoparticles and tuning temperature gradients at the nanoscale to precisely and locally reach the optimal temperature of each immobilized enzyme. This will allow an unprecedented spatio-temporal control over the kinetics of multi-enzymatic cascades by remotely applying alternating magnetic fields. To ensure an easy separation, re-utilization and integration into bioreactors, these conjugates will be integrated within porous microparticles. To meet this technological break-through we will need to design and fabricate a new generation of magnetic bioreactors specific to the field of Biocatalysis. We will need to answer fundamental questions about the physical mechanisms that govern heat transfer/diffusion between magnetic materials and biomolecules at different spatial scales by bringing together different scientific and technological disciplines and expertise.  HOTZYMES will thus contribute to change current industrial biotransformations from an unsatisfactory current paradigm (uncoordinated enzyme function, sequential reactions, disposable bioprocesses) into a game-changing breakthrough (coordinated enzyme function, concurrent reactions, recyclable bioprocesses).


**Keywords:** Ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SInGle cells iN AuToimmUne inflammatoRy disEases' (SIGNATURE), addressing dissemination and exploitation.

assistant: **Impact**

Autoimmune disorders are highlyImmune-mediated disorders are highly heterogenenous entities for which the mechanisms of disease progression and  therapeutic responses are only recently beginning to be understood. The patterns of transcriptome are the reflection of  distinct cell types that are involved in the development of the disease process. Our plan is to approach the diseases  beginning from a global view that allows us to then come down to the most relevant cell types in tissues and blood. In  addition, by understanding disease heterogeneity and diseases similarities, we can also identify the best pathways to be  targeted with specific biological treatments. The diseases involved are systemic lupus erythematosus, rheumatoid arthritis,  multiple sclerosis, asthma, chronic obstructive pulmonary disease, Crohn´s disease and ulcerative colitis. Based on a unique  ongoing platform of clinical groups across Europe and specialists in cell and molecular profiling, imaging analyses, single cell  sequencing and analysis, we will identify the molecular basis of each of the diseases heterogeneity, the mechanisms of  treatment non responsiveness, and develop a specialized training program where students will be able to visualize the overall work from design to analysis of the data and become engaged in the unique multi-disciplinariry of this platform. The platform will have available existing clinical studies and clinical trials, but will be also producing new data from prospective studies where samples and tissues for each disease, based on the appropriate indications will be obtained with special protocols, for the study. The engaged students will be permeated by the latest advances in not one, but several new  approaches and systems biology modelling, and develop out-of-the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Radiotherapy for breast cancer and subsequent risk of cardiovascular events'.

assistant: **Objectives**

There are over a million survivors of breast cancer in Europe today and this number is increasing rapidly due to increased incidence, improvements in treatment, and screening programmes. A recent overview of radiotherapy for early breast cancer showed that mortality from breast cancer was reduced in women given radiotherapy. This benefit was largely offset by the finding that women given radiotherapy experienced an increased risk of mortality from other causes, particularly cardiovascular disease. For breast cancer, improvements in radiotherapy techniques in recent years have reduced radiation doses to the heart. Many radiotherapy regimens still involve cardiac doses that may range up to a few Gy, and it seems likely that some cardiovascular risk remains with these regimens. There is thus an urgent need to obtain additional quantitative information on the size of the risk, so that it can be taken into account in the decision as to whether or not to treat a woman with radiotherapy and, if treatment is to be given, which radiotherapy regimen to use. Results from this study will provide information about the size of the cardiovascular risk from both past and present breast cancer radiotherapy regimens. This will be achieved by: (i) conducting large follow-up studies of women with breast cancer in Sweden and Denmark; (ii) developing methods to assess the radiation dose to the heart from different breast cancer radiotherapy regimens; (iii) conducting nested-case control studies within the two cohorts to establish a dose-response relationship for cardiac dose and cardiovascular risk. The information obtained about the risk of cardiovascular disease following low doses of radiation will also be of considerable practical use in other areas of radiological protection, and may be