RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tissue Resident Memory (Trm) CD8+ T cells: Genome-wide dissection of cellular differentiation and heterogeneity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Tissue-resident memory (Trm) cells are non-circulating T lymphocytes of non-lymphoid tissues and organs that provide localized protection at barrier surfaces such as skin, gut and lungs. In human skin, Trm cells represent the predominant lymphocyte population, comprising subsets with different cytokine profiles and cytotoxic capacity. They represent an integral part of barrier immunity, mounting tailored responses to diverse pathogens, but potentially also eliciting immune pathology. Trm cell differentiation, effector mechanisms and cellular interactions remain poorly defined. I aim to decipher cytotoxic Trm cell biology in greater depth, unravelling the epigenetic framework of phenotypically and functionally distinct CD8+ Trm populations. I will rely on state-of-the-art methodologies at the host institution. Through unique collaborations and a multidisciplinary approach encompassing advanced flow cytometry, cell sorting and high-throughput sequencing, I propose to map genome-wide chromatin accessibility in skin and gut Trm cell subsets. Identification of regulatory elements critical for cell functions coupled with analyses of transcription factor binding promise to unravel the molecular mechanisms defining Trm cell ontogeny, function and tissue-specific imprinting. Moreover, with potential application to limited patient samples, single-cell RNA sequencing of cytokine-producing cells will provide a map of Trm cell heterogeneity with unprecedented resolution. This project will illuminate the role of the microenvironment in shaping tissue-resident memory, with ultimate goals to understand Trm cell-related diseases and determine common denominators required to establish tissue residency and provide basis for generating and shaping Trm cells in future cellular immunotherapi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European and developing countries clinical trials programme (EDCTP)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The objective of this Accompanying Measure is to create the European Clinical Trials Platform for Poverty Related Diseases (ECTP). This will be achieved by systematic analysis of the proposed functions and operational structure of theft, based on Article 169 of the Treaty of Rome. This analysis will be also based on information regarding EU National Programmes, other European and DCinitiatives, and extensive consultations with the stakeholders. The ultimate goal of the future ECTP will be that new vaccines, drugs and health interventions could be properly and efficiently tested for safety, efficacy and effectiveness, and finally delivered faster in an improved health system to the needy populations. The ECTP must be driven by the needs of Desist main operational goal will be accelerate the development and evaluation of effective interventions against diseases linked to poverty.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Understanding the global effect of corporate tax reforms' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Despite the wide-spread cross-border operations of firms, the lack of appropriate data has so far precluded a knowledge-based understanding of the international repercussions of corporate tax policies.  TAXGLOBAL provides novel insights into the cross-border effect of firm taxation on economic activity. Given the recent tax reform in the United States and a surge of corporate tax reforms to be expected in Europe in the near future (e.g. France, the United Kingdom), such insights are now needed more than ever. It is essential to fully understand and quantify the cross-border impact of corporate tax policy in order to enhance job creation, sustainable investment and productivity growth in a globalized economy. TAXGLOBAL will provide a new understanding of the issue by compiling detailed high-quality data from Norway and analysing it in a quasi-experimental research design. In particular, I will (i) merge several administrative data sets on the domestic and foreign operations of companies which are obtained directly from the administrative and statistical authorities to which they report. This new and unique database will provide an unprecedented opportunity to study in detail the cross-border links on the level of the individual firm. I will (ii) compile a comprehensive and complementary database of all corporate tax reforms in a broad selection of countries to which firms are exposed via foreign affiliates. The information will then (iii) be combined and analysed using state-of-the-art regression models. This integral study of cross-border tax effects using administrative data for multinational firms will advance the research field with new insights into the global effect of tax policy on real business activity, as well as providing policy makers with a novel understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of life changing drugs for patients suffering from severe and fatal neurological disorders' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

AtmosR is a start-up whose mission is to develop innovative therapeutic solutions for patients suffering from severe and often fatal disorders of the central nervous system.Our company has established a technology in order to develop treatments for aggregate pathologies (such as ALS, Kennedy disease, Multisystem Atrophy, Parkinson, Huntington...) which represent a major health problem considering the high number of patients worldwide and the high unmet medical need. The first disorder targeted by AtmosR is Congenital Central Hypoventilation Syndrome (CCHS), a rare genetic syndrome which presents as its main symptom severe periods of hypoventilation. Patients are kept alive thanks to mechanical ventilation administered through a tracheostomy. Our goal is to develop a drug that will be life changing for patients and their families, liberating them from the machine, lifting the vital risk and allowing them to live independently.Our team consists of multidisciplinary profiles with experience in both drug development, particularly in the field of rare diseases, and in business management. As a spin-off of the french CCHS patient organization, we work in close cooperation with the international academic experts in CCHS, especially in France, Italy and Israël. We have identified a Hit compound ATS-003 that is active in both in vitro and in vivo CCHS robust models and we have optimized the compound thanks to a chemistry program in order to improve its efficiency and lower its toxicity for a better long term use tolerance. We are starting regulatory preclinical work in 2023 with this new Lead compound and have planned the first clinical trials by mid 2025 and an early drug access for patients in 2027.In addition to CCHS, we have identified  several disorders with similar protein
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'INhibiting mechanoTRansduction as a novel approach for Oncology theraPY (INTROPY)' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Increased tissue stiffness is a hallmark of many solid tumours, driving tumour progression. This occurs through mechanotransduction, the process by which cells sense and respond to mechanical signals. Our lab has identified a key interaction between two proteins, essential for mechanotransduction. This interaction is triggered by force-induced unfolding of a target protein, which occurs only in stiff tissues. Hence, we propose a novel therapeutic approach that targets mechanotransduction by inhibiting the stiffness-induced unfolding of the target protein. This innovative approach has the potential to transform cancer therapy and provide new insights into the role of mechanical signals in disease progression. We developed a thermal shift assay to identify molecules that stabilize the target and inhibit its unfolding. High throughput Screening (HTS) of ~5,000 molecules resulted in 4 hits with confirmed specific binding by NMR analysis. Two additional hits were identified each through structure-based virtual screening and a peptide-based approach, with confirmed binding through NMR analysis. In this project, we aim to validate these 6 hits, and to provide proof-of-concept evidence of their potential for cancer therapy. First, we will validate hits in vitro and in cellular assays. Second, we will optimize them with medicinal chemists to obtain lead molecules. Third, we will evaluate resulting lead molecules in an in vivo mouse breast cancer model. By the end of the project, we expect our data to be sufficient to attract private investment and establish a spin-off company to pursue drug development into clinical phases. This will lead to a first-inclass mechanoinhibitor drug, with potential applications in cancer (with a focus on breast and pancreatic cancer) and other condi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Redefining and repositioning public service broadcasting in the digital and multiplatform media scenario: agents and strategies – An international comparison within the European Union' (PSB-DIGITAL) targeting Seventh Framework.

assistant: **Abstract**

The digital and multiplatform scenario implies important changes in the structure, the business models and the reception patterns of the media. It sets a clear inflection point concerning the position and the role of Public Service Broadcasting. Divergent opinions coexist: On the one hand, free market and competition are considered sufficient to guarantee those values and functions that once legitimized PSB. On the other hand, the new possibilities resulting from digitalisation and the convergence of distribution platforms are seen as ways to improve the performance of public operators. This research aims to investigate the impact of those facts on PSB and what strategies are implemented in order to redefine its remit and to reposition its operators in the new media context. First, the current transformations affecting the media are analysed. New tendencies and operational logics will be identified. As a result, a theoretical model concerning the opportunities and challenges for PSB in the digital scenario will be designed and contrasted with the selected national cases. Next, the research is focused on the PSB adaptation strategies. The articulation of their elements –network of agents, procedures and goals– varies depending on the particularities of each national media market, on the political tradition and on the perception of the new communication context. Considering this diversity within the EU, an international comparison of these strategies will be carried out. The analysed countries are Germany, Spain and Poland. The final objective of this project is double. First, it has a strong theoretical ambition, wanting to contribute to the development of the PSB studies. Secondly, it aims to produce valuable pragmatic knowledge by means of detecting best practices amon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Catalytic Enantioselective Allene Cycloisomerisation Reactions for Alkaloid Total Synthesis' in the context of a Horizon 2020 call.

assistant: **Objectives**

A new catalytic enantioselective cycloisomerisation reaction for the direct creation of the azabicyclic core of strychnos alkaloids is proposed. Strychnos alkaloids have been the subject of intensive investigation over the last decades.  Recently, leuconicines A and B, which are new members of the Strychnos alkaloid family, have been isolated from extracts of the Malaysian plant Leuconotis maingayi. Leuconicines possess significant bioactivity and they potently reverse multidrug resistance in vincristine-resistant leukemia cells. However, further studies into the biological profile of these natural products are hindered due to insufficient quantities being available from the natural source. In order to secure sufficient quantities and fully determine the therapeutic potential of the leuconicines, a new source of these target molecules is required. A new synthetic route which develops and incorporates ‘state-of-the-art’ methodologies to rapidly forge the extremely complex 6,5,5,6,6,6 hexacyclic ring system and 4 stereocenters, will provide the material. Nevertheless, the synthetic routes toward complex natural products are usually long, contain many individual steps and involve manipulations after each step. For these reasons, new, simple and synthetically efficient organic transformations which reduce the drain of resources are desired. This Fellowship project combines total synthesis, new catalytic enantioselective methodology development, computational calculations and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Identity and biogeochemical role of chemoautotrophic prokaryotes in aquatic ecosystems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

We aim to identify relevant aquatic chemoautotrophic prokaryotes, which can play a key biogeochemical role with the capacity to fix CO2 independently of light. Although severely underestimated, chemoautotrophy can be widespread in natural systems and it can importantly participate in carbon cycling. Chemoautotrophs are highly diverse at the phylogenetical and metabolical levels, but our knowledge about both aspects is still very limited and will be assessed in this project. Firstly, we will identify active chemoautotrophs through Stable Isotope Probing with 13CO2. By this approach, we will label and isolate the nucleic acids of aquatic chemoautotrophs with 13C, and identify them through appropriate molecular tools. Large inserts of the isolated genomes will be analysed in fosmid clone libraries, in order to find genes that can shed light to the metabolic fashion of these organisms. This is particularly relevant in order to establish links between chemoautotrophy and other biogeochemical processes. We will focus on a specific group, Crenarchaoeta, which grows chemoautotrophically and could play a key role in nitrogen cycle in marine waters, but has not yet been studied in freshwater/brackish systems such as the ones we will sample. Finally, a survey of distribution and activity of chemoautotrophs will be done by the combination of in situ hybridization with specific probes and microautoradiography with 14CO2. This will allow us to quantify the amount of active cells of different groups in CO2 uptake along environmental gradients (transcending the freshwater-coastal waters boundary), and evaluate their biogeochemical relevance in aquatic ecosystems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Social Interaction and Entrainment using Music PeRformance Experimentation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

SIEMPRE develops research theoretical and methodological frameworks, computational models, and algorithms for the analysis of creative communication within groups of people, important also for future ICT (e.g. social media, on-line and mobile communities, web 2.0). Focus is on ensemble musical performance and audience experience, ideal testbed for the development of models and techniques for measuring creative social interaction in ecological framework. We focus on entrainment, emotional contagion, co-creation, each studied at two levels – between performers, between performer and audience - both during explicit communication process (e.g., between orchestra conductor and musicians) and during implicit synchronisation in emotionally intense experiences (joint music performance; audience live experience). Methodological framework will enable novel approaches to research challenges, including the integration in research teams of outstanding artists (funded by external projects). Expressive Movement, Audio, Physiological (eMAP) multi-layer multimodal features will be extracted from participants using real-time, synchronized, multi-modal feature extraction techniques, and are inputs for theoretical and computational models. Challenges and objectives: key factors driving interpersonal synchronisation of participants; identify specific roles inside the group (e.g., leadership, hierarchy); general principles concerning influence of individuals over others; factors that determine feelings of group cohesion or a sense of shared meaning; how eMAPs confirm the validity of reports by participants; how social context affects individual intrapersonal synchronization of eMAP and vice-versa; how emotion of the individual affects the collaborative creative product; neurophysiological fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Neuromodulation of lymphatic function in intestinal Peyer's patches'.

assistant: **Innovation**

The intestine hosts a vast neuronal system, a large population of immune cells, diverse microbiota, and a complex blood and lymphatic network. The intestinal lymphatic network comprises vessels and lymphoid organs, called Peyer’s patches (PPs), that together play important roles in dietary fat absorption, mucosal immune responses and trafficking of immune cells to the rest of the body. This intestinal immune cell trafficking is key in gut-to-organ communication, and its disruption leads to immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD). PP lymphatics are major routes for B- and T-cell egress from the intestine. Yet, little is known about the specific signals that modulate lymphatic control of immune cell trafficking.This project aims to explore the novel hypothesis that a synergistic interaction between neuronal signals and PP lymphatics modulates immunity and inflammation. Building on insights from single-cell RNA sequencing of PPs, I will investigate the role of the adrenergic receptor ADRA1B in lymphatic endothelial cells. This research will focus on characterizing the molecular changes in PP lymphatic cells and elucidating patterns of immune cell egress from the gut. Also, I will examine how adrenergic signalling influences PP lymphatic function and immune cell trafficking under inflammation, mimicking IBD condition. Lastly, I will extend these findings from mouse models to humans by defining the architecture and molecular signatures of human PP endothelial cells.This multidisciplinary project will integrate high-resolution imaging, intravital microscopy, and deep molecular profiling of both mouse and human endothelial cells to uncover this previously unexplored neuronal-lymphatic-immune axis. Given the physiological relevance of PP l