RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sulfation pathways in Health and Disease: SUPA-HD' (SUPA-HD) under Seventh Framework.

assistant: **Objectives**

Sulfated biomolecules are omnipresent in biology. Highly diverse biomolecules are sulfated by an armada of sulfotransferases that depend on provision of active sulfate in the form of 3’-phospho-adenosine-5’-phosphosulfate (PAPS) for action. In humans, PAPS is exclusively provided by the two bifunctional PAPS synthases PAPSS1 and PAPSS2. A growing number of studies report patients with various mutations in the PAPSS2 gene with clinical phenotypes ranging from bone and cartilage mal-formations to severely disturbed androgen metabolism. PAPSS2 has been characterised as an unstable protein. The nucleotide APS (adenosine-5’-phosphosulfate) is a specific stabiliser of PAPSS2 in vitro. However, the cellular concentration of APS, and the related nucleotides PAPS and PAP are unknown. Within the cell, scaffold proteins or chaperones may be involved in stabilising the PAPSS2 protein. Furthermore, nuclear or cytoplasmic PAPSS variants were analysed within the context of DHEA sulfation. We observed that cytosolic PAPSS2 supported DHEA sulfation by cytoplasmic sulfotransferase SULT2A1 to a larger extent than cytosolic PAPSS1. PAPSS2 may hence be involved in various, yet unknown protein interactions. The present proposal combines the biochemical expertise of the Applicant with the profound endocrinology and translational knowledge of the Host as well as the excellent know-how for targeted metabolite quantification that exists in Birmingham. With these pillars we are in the unique position to correlate the cellular phenotypes with the different disease-causing PAPSS2 mutations, to find novel protein interaction partners of PAPS synthases by proteomics and to develop and apply innovative analytical methodology to quantify APS, PAPS and PAP within mammalian cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'REconciling sCience, Innovation and Precaution through the Engagement of Stakeholders'.

assistant: **Innovation**

RECIPES seeks to address the highly debated question as to how to protect health and safety of persons and the environment whilst promoting innovation. RECIPES is pioneering because of its a ground-breaking and interdisciplinary endeavour involving the integration of social and legal discipline and based on co-creation with policy-makers and other stakeholders. It aims to reconcile science, innovation and precaution to foster social awareness and responsibility in the EU in research and innovation by developing new empirically sound and theory informed institutional design and tools. It will build effective cooperation between science and society and link scientific excellence with social awareness and responsibility. In order to fully grasp the complexity and the controversies around the precautionary principle, RECIPES will examine the application of the precautionary principle in international treaties, EU level and five countries. It will also carry out eight case-studies, so as to understand and explain the potential differences in the application of the precautionary principle in the different cases, which reflects the particular context of the case and reasoning behind the decision to invoke the precautionary principle. RECIPES will develop new tools for the application of the precautionary principle taking into account the innovation principle. It will involve engagement of stakeholders in all stages of the research. It will moreover develop mechanisms for public involvement in research and innovation. It will develop scenarios for the future application of the precautionary principle and from there, it will co-create a new approach to the precautionary principle and new tolls to help policymakers and other stakeholders to assess risks and uncertainty and allow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Sailing into Modernity: Comparative Perspectives on the Sixteenth and Seventeenth Century European Economic Transition'.

assistant: **Concept**

This research project analyses the economic transition in Early Modern Europe through an innovative and interdisciplinary approach that will employ tools from legal, economic and social history for the comparative analysis of the legal position and the economic treatment of sailors active in the Mediterranean. Since Fernand Braudel coined the expression ‘invasion of the northerners’, the subject of how English and Dutch shipping overtook local Mediterranean powers has been a classic topic of economic history. But due to the poor survival of traditional economic documentation for this period, we still know little about the details of how this happened in practice, and existing debates are stalling because of a lack of detailed comparative research. This project offers the opportunity to move these debates forward by analysing alternative documentary evidence (from judicial and notarial archives), which allows considerable methodological advances through the detailed comparative analysis of the protagonists’ trading strategies. It is a central contention of this project that legal and financial differences in the treatment of crews were one of the crucial factors in the success of northern European economies in their commercial penetration of the Mediterranean, a necessary step in their struggle for global hegemony. A comparative approach to the study of wage controversies in four European economies which had a strong maritime sector – Italy, England, France, Netherlands – will bring new light on the everyday legal cases with which international commercial law was being formulated on the ground, and with an interesting new perspective of the effect of economic activities on the development of legal institutions. These topics have also a strong connection to contemporary i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Innovative Approaches for an Integrated Use of Algae in Sustainable Aquaculture Practices and High-Value Food applications'.

assistant: **Concept**

The Farm to Fork Strategy of the European Green Deal has acknowledged the potential of algae to become an important source of alternative low-carbon footprint protein and contribute to improve the sustainability and competitiveness of the aquaculture sector.  Nonetheless, the European algae industry is still at an early phase lagging behind the overall increase seen at a global level, mostly driven by Asia. Within this context, INNOAQUA aims to pave the path towards the upcoming sustainable and diversified EU in-land aquaculture industry by leaning on the demonstration and mainstreaming of innovative algae-based foods and solutions, and ecology, circularity and digitalization concepts. To this end, the project will address main barriers hindering the growth of the sector, starting with the demonstration at a pre-commercial level (TRL6-7) of the operational, technical, and socio-economic robustness of digitally enhanced integrated fish and algae RAS-IMTA cultivation systems, continued by the piloting of optimised processing techniques following biorefinery principles and the formulation of high added value seafood products. All this, accompanied by a dedicated waste minimisation and valorisation strategy to help optimizing and increasing its economic and sustainability performance. Moreover, INNOAQUA will also work on understanding how consumer perceptions and social norms influence the consumption of innovative seafood products by co-creating the products together with end-users and simulating their uptake in digital models of communities to identify effective market deployment and penetration strategies. Lastly, INNOAQUA will be enhanced by the adoption of a multi-level outreaching strategy which will the development of robust dissemination, communication and exploitat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unraveling the role of spinal GABApre neurons in presynaptic modulation during locomotion'.

assistant: **Innovation**

Presynaptic modulation is a cornerstone of neural function, shaping everything from basic motor control to sensory processing and motor learning. It is a powerful mechanism that allow the fine tuning of a  neuron selected target through an axonal modulation. In the spinal cord, this potent modulation is mediated by ""GABApre"" neurons. However, although widely studied ex-vivo, their function during naturalistic behaviors remains poorly understood due to technical challenges limiting in vivo access to spinal neurons. By leveraging advanced methodologies, such as in vivo electrophysiological recordings with Neuropixel probes during naturalistic locomotion, this project aims to uncover mechanisms that have so far remained elusive. Combining genetic manipulation, viral targeting, and high-resolution 3D kinematic analysis, this project will investigate the activity of GABApre neurons and their impact on motoneuron dynamics and locomotor performance across movement phases and muscle recruitment. Additionally, we will explore the recently observed dual effect of GABApre neurons and determine whether they consist of distinct subpopulations and whether they exhibit distinct context-dependent functions. By examining GABApre function during natural locomotion, this work will bridge the gap between previous non-physiological studies and the real-world relevance of presynaptic modulation, offering new insights into sensorimotor integration and adaptive motor behavior. While fundamental, this project’s discoveries will provide a crucial foundation for the design of innovative therapeutic approaches.""


**Keywords:** Sensorimotor Control, Spinal Cord, Circuit Dissection, Electrophysiology, Behavior
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Building pathways towards FOOD 2030-led urban food policies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Meeting the challenges of providing European citizens with affordable, safe and nutritious food and of creating healthier and more sustainable City Region Food Systems raises the need for the development of integrated urban food policies that are able to engage with the complexity of the food system. Today’s leading platform for this endeavour is the Milan Urban Food Policy Pact, a powerful global network of learning cities experimenting around, and advocating for, the implementation of a holistic approach to food system transformation. FOODTRAILS, a four-year project led by the City of Milan, brings together a Consortium of 19 partners (including 11 EU cities, 3 universities and 5 prominent food system stakeholders), which will be followed by another 21 worldwide cities, to translate the MUFPP’s shared vision and collective commitment to integrated urban food policies into measurable and long-term progress towards sustainable food systems.  Building on the momentum created by the recent emergence of cities as key sites to reimagine, enact and engage with food system transformation, FOOD TRAILS will provide city and regional governments and other agents of change with evidence-based policy narratives, co-designed and verified through the activities of 11 multi-objective and multi-actor Living Labs committed to addressing the 4 priority areas of the flagship FOOD 2030 framework. Using the existing knowledge on innovations for food system transformation, the Living Labs will co-design pilot projects that minimize the trade-offs between the 4 priorities of FOOD 2030 and that can function as an entry point for the development of integrated urban food policies. FOODTRAILS will also establish a pan-European Investors’ Living Lab to develop innovative financial instruments tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Power System Simulator based on Physics-Informed Neural Networks' (PINNSim) targeting Horizon Europe.

assistant: **Abstract**

This proposal puts forward a first-of-its-kind power system dynamics simulator based on neural networks: PINNSim. PINNSim aims to deliver a highly modular and scalable tool that can be up to 100x faster than any commercial power system simulator. This means that PINNSim can perform a power system stability assessment in 30 minutes instead of 2 days. We witness a dramatic shift from few large scale generators to millions of converter-based resources, such as solar, wind, batteries, and electric vehicles. Capturing the dynamic behavior of such a system is no longer possible with the conventional approximations. In case of fault, phenomena propagate much faster and an ElectroMagnetic Transient (EMT) simulation is necessary to accurately capture them. However, EMT is slow and computationally intensive. Uncertainty from solar and wind and the increased number of components requires the assessment of millions of critical scenarios so that power system operators eliminate blackout risk, and manufacturers design appropriate controllers for the safe operation of their equipment.PINNSim leverages physics-informed machine learning and GPU acceleration to model power system components. Its key novelty lies in the method it interconnects individual neural networks to form a “system of neural networks” that performs simulations at much higher speeds. Through this funding, we aim to scale PINNSim to handle larger, more complex power systems and incorporate a user interface, creating a user-friendly simulator capable of addressing a wide range of power system operation challenges.Our goal is to create a tool that will disrupt the power system simulation software landscape. We envision a library of component models based on neural networks, which can then be used in a plug’n’play fashio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BraiN20®: A paradigm shift in Acute Ischemic Stroke (AIS) patient management' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Acute Ischemic Stroke (AIS) represents 85% of strokes and is the 2nd leading cause of death and the leading cause of disability worldwide. Today, AIS patient management lies on imaging tools (multimodal CT/MRI) and scores to select patients for Endovascular treatment (EVT)  the gold standard. Still, its efficacy is limited to 46% due to the lack of tools to guide decision-making. BraiN20 is a non-invasive medical device class IIb that provides real-time monitoring of AIS patients brain viability, thereby predicting who will benefit from EVT. Time is Brain has the exclusive right to the IPR of a neurophysiological biomarker: N20, a SEP and surrogate of cerebral blood flow. TiB aims to implement the clinical trials to validate BraiN20, acquire CE-Mark and FDA clearance, and bring it to market. By providing real-time and continuous monitoring of brain viability, BraiN20 will accelerate stroke management and predict EVT outcome and offer tailored care for each patient.


**Keywords:** Neurophysiological biomarker (N20),Acute Ischemic Stroke,Mechanical Thrombectomy (MT),Endovascular Treatment (EVT),Ischemic penumbra,Intraoperative monitoring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hydrogen Storage and Fuel Cells for Optimised Renewable Energy Communities' (H2SCORE).

assistant: **Innovation**

H2SCORE aims to demonstrate how integrated Fuel Cell and Hydrogen (FCH) technologies can enable the next generation of Renewable Energy Communities (RECs), enhancing their decarbonisation, resilience, and energy autonomy. The project combines low-temperature (PEM electrolyser, metal hydride storage, PEM fuel cell) and high-temperature (reversible Solid Oxide Cell powered by syngas from local biomass) hydrogen systems in a modular, replicable setup.The concept will be demonstrated in the operational Valsesia REC (Quarona, Italy). The system will be fully integrated with the local electrical grid and District Heating Network, enabling sector coupling, and managed through an advanced Energy Management System aimed at multi-vector (electricity, heat, hydrogen, biomass) optimisation and oriented towards REC-specific objectives. A portable hydrogen-powered fuel cell genset will also be deployed for temporary or mobile use cases.This first-of-its-kind H2-REC will operate at TRL7 through a 12-month demonstration campaign, also including on-site detection of pollutant emissions and hydrogen leakages. A cloud-based monitoring tool will track REC KPIs in real time, support stakeholder engagement, and promote replicability.H2SCORE modelling framework integrates techno-economic, environmental, regulatory, safety, and social dimensions to guide both H2-REC impacts assessment and replication strategy. Four replication studies (Italy, Switzerland, Spain, Canada) will test the concept across different geographies, user needs, regulatory environments, and both on- and off-grid settings.The project builds on previous EU-funded FCH projects and leverages the complementary expertise of 15 partners, fostering synergies with relevant EU and national initiatives to scale up hydrogen-ready RECs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The dark side of the genome: systematically studying the biology of repressive elements—silencers—in the human genome' (Silencer) under Horizon 2020.

assistant: **Objectives**

Less than 1.5% of the human genome contains protein coding information of the estimated 25,000 genes. The rest of the non-coding genome includes many regulatory elements that control the spatial and temporal transcription of genes. With the help of the non-coding regulatory elements, the diverse cell types and tissues of a complex human body could be derived from the combinational expression of a limited number of genes from the same copy of the genome. Most regulatory elements (REs) have been characterized extensively, e.g. promoters, enhancers and insulators. These REs have been implicated to play very important roles in cell physiology, tissue development and disease onsets. Surprisingly, one class of REs—silencers—which repress the transcription of genes, have not been systematically characterized and studied. I have developed a lentiviral system to systematically identify functional silencer elements. In the small-scale proof-of-principle experiments, by focusing on the transcriptional factor (TF) accessible DNA sequences, I showed that this system is robust to identify novel and bona fide silencers, which could be validated using complementary functional assays such as luciferase and CRISPR knockout assays. In this proposed research plan, I aim to identify silencers in an unbiased way, rather than focusing on TF accessible regions, to have a more general understanding of the biology of silencers. Based on the unbiased identification of silencers, I aim to identify a general pattern of epigenetic modifications of silencers, unique combination of sequence motifs, responsible regulatory TFs, biological pathways that are regulated by silencers, diseases that might be related to mutations in silencers, and finally better manipulation strategies of silencers.


**Keywor