RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'In vivo genetic screen in xenotransplanted cord blood-derived macrophages to identify regulators of human border-associated macrophage identities'.

assistant: **Innovation**

Border-associated macrophages (BAMs) are macrophages that reside in specific anatomical interfaces between the brain and the blood circulation. Due to limited access to fresh human tissues from those anatomical sites, our understanding of human BAM development and function remains poor. It was previously observed that human hematopoietic stem cells from umbilical cord blood take up residence and differentiate into BAM-like macrophages when injected into the brains of neonatal mice expressing human colony-stimulating factor 1 (hCSF1). Single-cell RNA-sequencing confirmed strikingly similar transcriptomic signatures of those human macrophages to BAMs. The resulting chimeric mouse model represents an innovative platform in which the development and function of human BAMs could be investigated. In the current study, brain-xenotransplanted human cord blood-derived macrophages will be further characterized to assess whether they show location-specific molecular signatures, as do human BAMs. Then, an in vivo CRISPR knockout screen will be performed on those cells in order to decipher the genetic regulators of human BAM identities. I, the applicant, have extensive experience in brain immunology and in working with macrophages. I will work on developing and applying an in vivo CRISPR screen workflow in the chimeric mouse model developed by the laboratory of Dr. Movahedi (VUB, Belgium) who has established himself as a leader in brain macrophage research. This project will offer me the invaluable opportunity to learn genome editing techniques, design and execution of mouse experiments, as well as single-cell -omic experiments using state-of-the-art instrument. By bridging my existing knowledge with the cutting-edge techniques offered at the host laboratory, I aim to lay the founda
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Validation of a point-of-care H-FABP test for a rapid exclusion of Acute Myocardial Infarction in patients with cardiac complaints.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

There is a pressing need for improvement of the diagnosis of acute myocardial infarction (AMI) for healthcare professionals (HCP). 1–1,5% of the population consult a physician each year with chest pain complaints. While the majority (60–80%) of these patients are sent to a hospital for further inspection, eventually AMI is diagnosed in only 8–18% of these cases. Consequently, a rapid, objective test that helps to better select patients suspected of AMI by HCPs would reduce the number of unnecessary hospital referrals and admissions, thereby saving costs and contributing to a more sustainable healthcare.FABPulous (SME) is a medical device company spun out of Maastricht University in 2008. The core of the company is its innovative proprietary technology that allows a simple, robust and ultra-rapid diluted plasma preparation from a drop of blood. This offers great advantages over current technologies in point-of-care and home testing.The CE-marked H-FABP True Rapid Test (H-FABP TRT) developed by FABPulous aids the HCP in ruling out AMI with a very high level of confidence. It is based on the heart-type fatty acid binding protein (H-FABP), which can be used as biomarker for AMI. With H-FABP TRT a physician is able to rule out the occurrence of an AMI for a large proportion of patients suspected of AMI. It is intended for use in both primary and emergency care.In this project FABPulous seeks to medico-economically validate H-FABP TRT in primary (Netherlands+Belgium) and emergency care (UK) by performing two clinical trials. Outcomes of these studies lead to adoption of H-FABP TRT in medical guidelines and form the basis of a request for reimbursement towards health insurers. In this project FABPulous will improve the production process as well in order to decrease the cost p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Feasibility Analysis on the Extraction of Lycopene from Tomato Peel through Organic Synthesis' (LycoSOL).

assistant: **Innovation**

Artificial food colouring makes the foods more appealing and desirable, a tactic the food industry has been capitalising on for decades. One of the most used artificial food colouring is Carmine or E120 (Used in Nestle Nesquik, Rainbow Mentos, etc.)  a pigment of a bright-red colour obtained from the aluminium salt of carminic acid, which is produced by some scale insects, such as the cochineal scale and the Polish cochineal, and is used as a general term for a particularly deep-red colour of the same name. While the safety of these dyes has been called into question, consumer advocacy groups and recent scientific research  have linked these food dyes to a number of potential health problems, most notably, certain types of cancer in animals and attention-deficit disorder and hyperactivity in children. The link between artificial colours and behavioral problems is a concern, especially for parents of children diagnosed with ADHD.LycoSOL extracts and formulate natural ingredients (nutraceuticals and phytochemicals) from the waste products of food processing, by using (i) biological, (ii) sustainable and (iii) environmentally friendly, novel processes to stop the use of synthetic food colouring, known to adversely affect the public health and replacing them by ingredients with major health benefits. BioCapSOL aims to provide an improved process for extracting and encapsulating biological content from plants and vegetables using benign chemistries that can be applied at an industrial scale. The LycoSOL extracts the carotenoids from waste by-products of tomato paste production through a 100% natural and low-cost production method. LycoSOL is currently at TRL6 stage. The global market size for lycopene amounts to €113M in 2018 and the market is expected to grow annually by 3.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DEciphering mechanisms of presynaptic reFINEment' to be submitted under Horizon 2020.

assistant: **Abstract**

The postdoctoral project aims to investigate the mechanisms underlying sensory experience driven synaptic and circuit refinement that occurs during critical periods of brain development. Presynaptic and postsynaptic refinement involving loss and strengthening of synaptic contacts are known to occur but how these processes are coordinated and  remains obscure. Failure to appropriately regulate this refinement underlies some common neurological disorders including autism and schizophrenia. The non-canonical NMDA-receptor subunit GluN3A presents a likely key factor in the timely remodelling of these circuits. This project will interrogate the completely unknown roles GluN3A plays in presynaptic postnatal refinement processes. The cellular location and trans-synaptic coordination that may define these events mediated by GluN3A will be carefully dissected through analysis of interhemispheric callosal projection axons using targeted delivery of transgenic reagents by in utero electroporation in the mouse brain. Chemogenetic and sensory deprivation approaches will provide exquisite control over activity and experience dependent roles within this refinement over critical windows of development. Revealing of cellular and molecular mechanisms that GluN3A functions through in presynaptic and axonal development will be guided by unbiased RNAseq data and explored via the latest cellular and transgenic tools. Follow up experiments assessing functional connectivity, in collaboration with colleagues at the hosting institute, will help understand the impacts on circuit function and synaptic communication arising from morphological changes of GluN3A perturbation and thus understand how healthy circuits and behaviour develop. A clearer knowledge of the molecular regulation of this synapti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Research Training to Decipher The Ub Code : identification of potential biomarkers and drug targets' (UbiCODE) targeting Horizon 2020.

assistant: **Abstract**

Essential role of protein modification by members of the Ubiquitin family: Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate protein function at several levels: to change their localisation, activity, their interaction with partner proteins or their stability at the right time and cellular compartment, according to the cell requirements. Defects in this homeostatic equilibrium result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Ub family members hold a homeostatic equilibrium within the cell and are interconnected in various ways including the regulation of enzymes that control the modified status of target proteins. Interestingly, Ub and Ub-like (UbL) proteins can modify themselves, forming intricate and complex chains. This landscape has recently expanded with the discovery of the formation of heterologous chains among UbL molecules including SUMO or NEDD8 but also other PTMs such as phosphorylation or acetylation. This unsuspected complexity of what is now known as the «Ubiquitin Code», which is an unknown universal language that needs to be deciphered to understand protein homeostasis and its associated pathologies. To decrypt this complex code requires joint collaborative multidisciplinary efforts at all levels, including the use of distinct molecular systems and model organisms and the latest technological developments to explore chemical, biochemical, molecular, pharmacological and clinical aspects of protein modification by members of the Ub family. UbiCODE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Effects of wine polyphenols on human health-genomic and proteomic approaches'.

assistant: **Concept**

The influence of phenol compounds present in wine on gene expression is assessed with established in vitro cell cultures. Novel mechanisms identified in the in vitro work are translated to the in vivo situation using genomic and polemic technology. Red wine extract and five polyphenolic compounds usually present in wine will be assessed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fast, Unbiased & Accurate Human Identification: Artificial Intelligence at the service of Physical and Forensic Anthropology' in the context of a Horizon 2020 call.

assistant: **Objectives**

The increasing number of mass disasters, and the untraceable (and shameful) number of unidentified people worldwide, combined with new challenges due to mass migrations, pose human identification as a great challenge in the preservation and defense of human rights in today’s society. There is an urgent need to provide forensic practitioners with accurate, robust, unbiased and automate identification systems. The field of artificial intelligence (AI) has the potential to develop those tools, however there is an absence of industrial initiatives exploiting these emerging technologies that have so far curbed its application to practical identification scenarios.  SKELETON-ID fills this technological gap by bringing a novel computer-aided automatic paradigm for human identification based on forensic anthropology methods, thanks to our innovative own-developed methodologies and AI-based automation algorithms. We apply methods of AI to automate identification techniques such as Craniofacial Superimposition and Comparative Radiography, through unbiased and accurate analysis and comparison of ante-mortem data (pictures, X-ray) with post-mortem 3D bone models; and Biological Profile estimation, both dead and alive, from X-ray to 2D and 3D images. Our platform provides a fast and low-cost forensic tool that offers complementary methods to other solutions and is applicable when other techniques are not (e.g. decomposed bodies, lack of trustable records). With SKELETON-ID, Panacea C. Research (a Spanish SME) aspires to be a global reference in the area of physical and forensic anthropology. In the long term, we envision becoming a human group highly qualified and specialized, capable of generating and hosting new ideas and products with a transforming effect.This project will great
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Nidovirus Replication Complexes: How enzymes shape viral genomes'.

assistant: **Concept**

Nidoviruses are an intriguing group of +RNA viruses, whose diverse genome sizes (11-41 kb) reflect a long history of adaptation to suit specific niches. They remain mostly neglected, with the exception of the large-genome Coronaviridae (CoV) family (32 kb), which includes the notorious human pathogen SARS-CoV-2. At the other end of the size-spectrum is the small-genome Arteriviridae (ArV) family (11 kb), an understudied group of prevalent, animal-infecting pathogens. Viral replication is mediated by a suite of enzymes known as the replication transcription complex (RTC), at the core of which is the RNA-dependent RNA polymerase (RdRp) and its unique Nterminal domain, known as the NiRAN. NidoRep aims to bridge the prevalent knowledge-gap between small and large genome nidoviruses, by deciphering the specific structural and mechanistic features of the RTC that regulate genome replication across such vastly different viruses. It will be divided into three distinct objectives: Objective 1 will focus on small-genome nidoviruses, providing the first structural and functional characterization of an ArV RTC. Objective 2 will probe how RdRp speed and fidelity have been fine-tuned to accommodate the distinct and conflicting replication requirements of diverse nidoviruses. This will be achieved through the development of an innovative in vitro sequencing assay, also providing a new and robust tool for screening drugs that corrupt RNA synthesis. Objective 3 will investigate the role of the NiRAN in initiation of RNA synthesis though protein-priming, providing new insight into the functional evolution of this complex domain, while also identifying novel drug-targeting sites. NidoRep will determine how specific viral enzymes have structurally and functionally evolved to support remark
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Low Cost Onshore Power Supply (LoCOPS)' (LoCOPS).

assistant: **Innovation**

The main objective of this project is to supply and demonstrate a competitive shore power supply also called Onshore PowerSupply (OPS) related to providing electricity for cruise ships when docked in port. OPS installations saves consumption offuel and eliminates the air pollution associated with the use of fuel. Many European cities are planning urban growth in areasnear ports and are frequently discussing ways of encouraging ships to use OPS to meet clean air objectives.Electricity supply in Europe has a frequency of 50 Hz but most cruise ships and other large vessels are designed for 60Hz.Thus, in European ports electricity has to be converted to 60 Hz by a quayside electricity converter. The cost of frequencyconverter grows proportionally with power consumption and thus for cruise ships holds a considerable part of the OPSinvestment. So far, ports in Europe have been restraint from investing in OPS installations of this type and size due to veryhigh equipment cost.The high equipment cost is seen as a consequence of a new market with very limited capable suppliers causing a highbargaining power in the favor of the selling part. Comparable trends were seen within the Wind power segment in the pastbut the wind turbines everlasting competition towards fossil fuels has kept focus on lowering cost of all parts of the turbineswith great success.PowerCon has for the last 5-6 years been a part of this success by adding significant savings into the industry with beyondstate of the art converter solutions at low cost. These solutions are in many aspects identical with the required for OPS,making it obviously to offer the same savings into the maritime sector, ensuring a reasonable return of investment for theports and for the benefit of the environment.The ambition of this pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantifying Migration Scenarios for Better Policy' under Horizon 2020.

assistant: **Concept**

The aim of QuantMig is to produce comprehensive, multi-perspective and robust quantitative migration scenarios to support various areas of European migration policy. The project will advance the methodology of scenario generation whilst being firmly grounded in cutting-edge developments in conceptualising, explaining, estimating and forecasting migration. QuantMig will further the understanding of conceptual foundations of European migration flows and their key drivers in origin, destination and transit countries. Particular focus will be on mobility of third-country nationals and decision-making of migrants. The scenarios will be based on a bespoke set of statistical estimates derived from a distinctive and comprehensive set of harmonised data on migration and its drivers. Rigorous and innovative methods will be developed and applied to creating interactive simulation models, describing scenario uncertainty, and providing early warnings. The unique features of QuantMig include building a comprehensive knowledge base on migration and its drivers, far beyond the state of the art. The strong quantitative slant of the project will improve migration data and related analytical methods, offering an innovative assessment of their quality and uncertainty, in line with the current European policy priorities. The project remains fully relevant to the work programme, addressing all specific areas of the call. Put together by a unique consortium of leading European institutions with excellence in demography and migration, in continuous dialogue with key users and stakeholders, QuantMig will deliver a range of directly applicable tools for policy support. The dissemination and policy activities will integrate the stakeholder perspective throughout the project. The project outputs:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Paratexts of the Bible. Analysis and Edition of the Greek Textual Transmission' under Seventh Framework.

assistant: **Concept**

This project takes a new look at an old text. The Bible is a fundamental book for the history of religious beliefs, cultural history, art history as well as many other fields. For centuries it has been read and copied multiple times. Thousands of medieval manuscripts survive. The process of transmission is considered here from a totally new perspective. While biblical manuscripts have so far been largely analysed as witnesses to an original text (“Urtext”), this project approaches each manuscript as a single witness to an act of reading and re-interpreting the text. In recent literary theory, attention has been drawn to “paratexts”, i.e. all material accompanying a main text. Virtually all biblical manuscripts have some of these features. Examples include brief introductions, biographies, tables of contents, poems, cross-references, prayers, and indexes. However, these paratexts have been neglected by scholars for two reasons: firstly because biblical studies traditionally concentrate on the “inspired text” itself; secondly because of the sheer amount of available material, which far exceeds the capacities of a single scholar. Moreover, being very short, these paratexts have often remained below the detection threshold, and since we are dealing with a rich and “liquid” transmission, many of them also present a methodological challenge.The project will therefore adopt a new approach. Firstly, it will catalogue all available material in an e Clavis, taking into account recent developments in the fields of structural codicology and digital technology. Secondly, it will develop a set of categories according to which each paratext of the New Testament will be edited according to internal criteria. This will be done with a view to the intrinsic value of each manuscript witnes