RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Implications and risks of engineering solar radiation to limit climate change' under Seventh Framework.

assistant: **Concept**

The overall goal of this project is to significantly increase the level of knowledge about the feasibility and implications of novel options (or “geoengineering concepts”), proposed recently to limit climate change.  Among these possibilities, a deliberate manipulation of the radiative budget of the Earth may allow a counterbalancing of the effects of continued greenhouse gas emissions on global temperature, but may also result in undesirable side effects for crucial parts of the Earth system and humankind. Three complex climate models will be used to quantify the effectiveness and side effects of such geoengineering concepts aiming at a reduction of the incoming solar radiation. Simulations of a climate modified through geoengineering will be performed based on IPCC type future emission scenarios. Economic modelling will be used to link benefits and side effects of the studied geoengineering concepts. The results of the study will be discussed with the scientific community, policy- and law-related communities and interested non-governmental organizations (NGOs).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biocatalytic Deracemisation of Atropisomeric Drug Candidates' (RAMESES), addressing dissemination and exploitation.

assistant: **Impact**

Drugs that are chiral due to slow bond rotation (atropisomeric) are becoming more prevalent, and atropisomerism is increasingly recognised as an asset rather than a hindrance in medicinal chemistry programmes. However, although some asymmetric routes to atropisomers are established, very few methods are applicable to ‘drug-like’ atropisomers – namely those that are heavily functionalised, hydrophilic and often heterocyclic target molecules, meaning that enantiomerically pure atropisomeric drug candidates are typically obtained by wasteful and inefficient resolution methods.This proposal will address this problem by developing the concept of enzymatic deracemisation – discovered incidentally during an ERC AdG study of controlled molecular motion – to the atropisomer classes typically found in medicinal chemistry development programmes. In contrast to classical means of obtaining enantiopure atropisomers, this proposed biocatalytic method overcomes the yield and waste limitations of classical resolution and is uniquely applicable to the polar, water-soluble drug candidates for which existing asymmetric methods fail. The method stands out as sustainable, versatile and capable of making potential chiral drugs of enormous value and will be transformative for how the chemical and pharmaceutical sectors produce atropisomeric drug molecules. The originality of the project stems directly from a newly discovered chemical process unique to our laboratory. The Research Team is composed of diverse specialists in synthesis, biocatalysis, complex reaction networks and drug development. Development of the method will involve close partnership with industrial partners to identify enzyme classes, methods and target molecules for use as case-studies to quantify the benefits of the technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Single-Use unit and Process Analytical Infrared Spectroscopy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Biopharmaceuticals are medical drugs typically produced by mammalian cells in so-called bioreactors. It takes on average 10-15 years to bring a new drug to the market. Biomanufacturing costs can account for up to 30% of the overall costs needed to approve a new medicine. Currently, monitoring of bioproduction is mostly performed by using offline equipment that lacks robustness and has a reduced operational flexibility. Bioreactors are increasingly being monitored online and on real-time by means of Process Analytical Technologies (PAT). However, state-of-the-art techniques render both sub-optimal product quality and product efficiency. A few existing technologies based on Raman spectroscopy are highly expensive and probes are not robust enough, requiring consecutive sterilisation steps to be reused (raising water and energy consumption). At IRUBIS GmbH (spin-off of the Technical University of Munich), we have developed SUPAIR, a novel and robust ATR-MIR Sensor System aiming to make online and single-use monitoring of bioreactors by mid-infrared spectroscopy to become standard in the manufacturing of medical drugs. This approach will lead to increased operational flexibility, reduced costs of the manufacturing process, and will accelerate time-to-market of higher quality medicines to the patients. In the course of the Phase 1 project, we have validated our technical and commercial roadmaps through pilot testing with relevant biopharmaceutical players. Now we are getting closer to market, and we expect to conclude all technical developments and lay the ground for a successful market commercialisation by undertaking EIC Accelerator Pilot project.


**Keywords:** Process Analytical Technologies, Bioprocessing technologies, biomanufacturing, biopharmaceuticals, Mid-infrared
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multimedia for open and dynamic executives learning' under Fifth Framework.

assistant: **Concept**

The MODEL project aims to develop a knowledge management (KM) system (methodological framework, software tools etc.) which enhances the organisational ability to capture, structure and transfer knowledge across the different organisational groups (departments etc.) and over time (from project to project). The key idea behind MODEL is a conceptual and practical shift from the informational retrieval approach in business and academic institutions, to the development of an integrated methodology that enable the capture of both explicit and tacit knowledge within the organisation and increase the effectiveness of learning materials. The MODEL KM system will be validated as a mean for enhancing the knowledge dissemination within organisations.Objectives: The projects aims to fulfil the following objectives: to identify factors which enable and constrain the capture, structure and diffusion of knowledge across the organisation and over time, to develop an organisational methodology which facilitates the capture of both explicit and tacit knowledge, to develop software applications which can store and structure the captured knowledge, to develop a learning platform (including methodological guidelines and S/W applications) which nurtures at both individual and organisational levels the knowing Capability, i.e. the capability to enact the skills which are associated with putting knowledge into practice, to test the system in a real-life organisational environment through action research with private companies and academic operators specialised in executives training.Work description:Work in the MODEL project will unfold in three phases. The analysis phase in the project will strive to collect and synthesize four distinct types of material required to elaborate the MODEL concept
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development and testing of zeolite membranes for gas separations', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Membranes offer distinct advantages over existing separation technologies, i.e. the prospect of having lower capital and operating costs and using significantly less energy. In addition, their simple design enables straightforward expansion of capacity. In particular, micro or mesoporous ceramic membranes offer the potential to overcome the limitations of polymeric membrane systems in terms of thermal and mechanical stability, chemical/physical degradation, operation at high temperatures, etc. In this respect, the aim of the present project is to develop a novel method of zeolite membrane fabrication and exploit some of the inherent and unique advantages of this membrane. In brief, the following technical objectives are pursued: 1) Development of silicalite/ZSM5 zeolite membranes Separations of interest::  p xylenes /o and m xylenes  high temperature hydrogen removal  linear paraffins / branched paraffins 2) Development of A and X zeolite membranes Separations of interest:  N2/O2 (5A), O2/N2 (4A)  high temperature hydrogen removal (3A, 5A)  N2/CH4 (4A), H2S/natural gas (5A)  CO2/CH4 (4A),SO2 NOx/flue gas (5A) 3) Optimisation of above zeolite membranes to enhance gas permeability 4) Effective dispersion of Cu(I) and/or Ag(l) cations on zeolite membranes Separations of interest:  olefins (CxH2x)/ paraffins (CxH2x+2) x=2,3,etc.  CO removal The above synthetic developments will be complemented by an experimental programme of permeability testing and theoretical evaluation. Most importantly though, the rationalization of the industrial performance of the developed membranes will be established through flowsheeting and techno economic studies to be undertaken by the participating (and sponsoring) membrane manufacturers and process engineering company. In addition, the end use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering the transport mechanisms of small xenobiotic molecules in synthetic yeast cell factories' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Industrial biotechnology employs synthetic cell factories to create bulk and fine chemicals and fuels from renewable resources, laying the basis for the future bio-based economy. The major part of the wanted bio-based chemicals are not native to the host cell, such as yeast, i.e. they are xenobiotic. Some xenobiotic compounds are readily secreted by synthetic cells, some are poorly secreted and some are not secreted at all, but how does this transport occur? Or why does it not occur? These fundamental questions remain to be answered and this will have great implications on industrial biotechnology, because improved secretion would bring down the production costs and enable the emergence of novel bio-based products. YEAST-TRANS will fill in this knowledge gap by carrying out the first systematic genome-scale transporter study to uncover the transport mechanisms of small xenobiotic molecules by synthetic yeast cells and to apply this knowledge for engineering more efficient cell factories for bio-based production of fuels and chemicals.


**Keywords:** transport proteins, Xenopus oocytes expression, Saccharomyces cerevisiae transportome, bio-based chemicals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of cattle at Prehistoric lake-dwelling sites in Switzerland: an investigation of husbandry practices and the spread of cultural influence.' (LAKEBOS) under Horizon 2020.

assistant: **Objectives**

The development of farming in the Neolithic fundamentally changed human life. Livestock animals and farming innovations are thought to have spread across Europe during the Neolithic period via two distinct dispersal routes: 1. along the Danube corridor and through central Europe and 2. along the Mediterranean coast. This resulted in two distinctive cultural areas linked with particular modes of animal husbandry; a central European area with cultures based on cattle herding, and a Mediterranean area with cultures based on caprine husbandry. These husbandry patterns became embedded in these regions and remained the focus of agricultural practices into the Bronze Age and beyond. Switzerland is located between these two geographical and cultural regions and the Neolithic and Bronze Age cultures here represent a rare meeting and interaction point between them, yet very little work has explored the nature of this. Switzerland also has many large assemblages of perfectly preserved faunal remains from prehistoric lake dwelling sites where precise dating of different settlement phases can be achieved, representing a rare opportunity for the study of human-animal interactions with incredible temporal precision.The LAKEBOS project will use cattle, the most common domestic species at Swiss prehistoric sites, and a vital part of the new Neolithic farming ‘package’, as a proxy for investigating the way in which prehistoric agricultural practices from central European and Mediterranean cultures passed through this region and interacted with each other. It will use archaeozoological methods to investigate body size and shape change and demographic fluctuations on both a spatial and temporal scale. It will also use ancient DNA to investigate the potential for the introduction of new cat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Imaging of Neuroinflammation in Neurodegenerative Diseases' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i)to identify novel mechanisms of regulation and function of microglia under various conditions (inflammatory stimuli; neurodegenerative and -regenerative model systems);(ii)to identify and implement new targets for activated microglia, which may serve for diagnostic (imaging) and therapeutic purposes;(iii)to design new molecular probes (tracers) for these novel targets and to implement and validate them in in vivo model systems and patients;(iv)to image and quantify modulated microglia activity in patients undergoing immune therapy for cognitive impairment and relate findings to clinical outcome.Within INMiND we bring together a group of excellent scientists with a proven background in efficiently accomplishing common scientific goals (FP6 project DiMI, www.dimi.eu), who belong to highly complementary fields of research (from genome-oriented to imaging scientists and clinicians), and who are dedicated to formulate novel image-guided therapeutic strategies for neuroinflammation related neurodegenerative diseases. The strength of this proposal is that, across Europe, it will coordinate research and training activities related to neuroinflammation, neurodegeneration/-regeneration and imaging with special emphasis on translating basic mechanisms into clinical applications that will provide health benefits for our aging population. With its intellectual excellence and its crucial mass the INMiND consortium will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Low-temperature CHEMical approaches to novel materials based on earth ABundant ELements.  Towards advanced electronic and optoelectronic applications' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The renewable energy technologies already available are not yet capable of competing with fossil fuels mainly due to a poorratio cost/efficiency. A clear example is photovoltaic energy, for which high costs and moderate performances yield too longpayback times, despite the huge amount of solar energy constantly reaching the Earth. The key to cheap and more efficientrenewable energy sources lies in the materials at the heart of the different technologies. The synthesis of novel materialswith superior tailored properties for each particular energy application, and the development of cheap and scalablefabrication protocols is therefore crucial if renewable energy technologies are to take a main share of modern society energymix. Thus I plan to focus on the synthesis and study of novel materials based on earth abundant elements, with tailoredproperties for application in photovoltaic cells and other electronic devices, such as transparent electronics. On a complementary research line, the design of simpler and more efficient cell (nano)architectures is another key factor in maximizing the efficiency/cost ration of solar cells. In this sense I intend to develop novel nanoarchitectures in which the two main processes in solar cells, namely light abslorption and charge extraction, are decoupled and thus can be separately tackled and optimized. I want to address these goals by using and developing facile, low-cost and scalable approaches. Thehydrothermal method has proven to be a very effective synthetic approach yielding both known and new phases. Moreover,it is a low cost method and easily scalable. I have also shown the efficiency of hydrothermal reactions for the fabrication ofhybrid nanostructures. Additionally, other low-cost, solution-based methods will be explored (elec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'OLFACTORY CODING: TEMPORAL PATTERNS OF MITRAL CELL RESPONSES TO ODORANTS' (OLFCOD).

assistant: **Innovation**

How do we smell? The main aim of this proposal is to contribute to the understanding of how odor information from the environment is perceived. Recent experiments have focused on spatial aspects of olfactory coding in the olfactory bulb and have shown that all the olfactory sensory neurons expressing one odorant receptor gene, from a family of 1000, converge into a few glomeruli. However, temporal aspects of response to odorants may play a very important role in olfactory coding in mammals. Therefore, we propose to measure the temporal patterns of mitral cell responses to odorants. A major innovative aspect of this proposal is the use of a multidisciplinary approach, in wich electrophysiological measurements of mitral cell activity will be made in gene-targeted mice, in which all lofactory sensory neurons that express a chosen odorant receptor gene also produce the green fluorescent protein. The use of these gene-targeted mice will allow to visually identify the glomeruli by using green fluorescent protein. The use of these gene-targeted mice will allow to visually identify the glomeruli. Recordings will be made by using odorants known to activate the chosen receptor. Various odorant concentrations and exposure times will be used. The results will provide new information on temporal aspects of olfactory coding. Dr. Giulietta Pinato, recipient of a EU Marie Curie Individual Fellowship, has acquired expertise in electrophysiological recordings from granule and mitral cells in the olfactory bulb in the laboratory of Prof. Midtgaard, Denmark, and would like to return to her home country, Italy, and carry on the proposed project in the laboratory of Prof. Anna Menini, an intenational leader in the field of olfaction. A European Reintegration Grant will be of great help for t