RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exploiting homomers to reveal new principles of protein interaction, polymerization and aggregation' (Homomers).

assistant: **Innovation**

In the protein universe, 30 to 50% of proteins self-assemble to form symmetrical complexes consisting of multiple copies of themselves, called homomers. A peculiarity of homomers is that any mutation is necessarily repeated in all subunits. In a symmetric dimer for example, any mutation of one copy is also found in the second identical copy. Depending where the mutation occurs on the surface, the repetitions of the mutation may or may not be “synergistic”, i.e., participate together to the formation of a new self-interaction. We propose that the consequences of a mutation depend mainly on two factors: (i) its location on the homomer’s surface, which influences its synergy and (ii) the symmetry type of the homomer. We anticipate that these two factors are tightly coupled to the probability that a random mutation triggers the infinite polymerization and aggregation of a homomer. We thus propose a two-pronged approach to analyze this question. (i) In silico, using homomers of known three-dimensional structure, we will infer a “risk factor” for every surface residue, reflecting its probability to be associated with polymerization. We anticipate that high-risk residues are, together with their environment, under pressure to avoid un-wanted interactions. We also anticipate those sites to be under stronger evolutionary constraints. (ii) In vivo, we will artificially introduce amino acid substitutions in homomers at sites that are at high or low-risk, and quantify the potential of these mutations to trigger aggregation or polymerization of the homomer. This project, which combines both theoretical and experimental biology, will help us unveil new basic physico-chemical properties of proteins and of their potential to form unwanted aggregates in cells. This knowledge will contri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Profiling Responders In Antibody Therapies' in the context of a Seventh Framework call.

assistant: **Objectives**

Therapeutic antibodies are the largest and fastest growing class of pharmaceutical biotechnology products, with annual sales above 30 billion US$. In some cases, antibody products have revolutionized the management of patients, e.g. TNF-blocking antibodies in Arthritis or Rituxan in lymphoma. However, for most antibody therapies, only a subset of patients benefit from treatment. Thus, there is an urgent need to develop more potent therapeutic antibodies and to understand the molecular basis for the differential responses of patients to treatment.This consortium consists of European centres of excellence being pioneers in the field of therapeutic antibody development and (pre-) clinical studies and will tackle both of these challenges:Innovative immunocytokines L19-IL2 and F8-IL10 are developed by Philogen for the treatment of metastatic melanoma and rheumatoid arthritis respectively at multiple clinical centres including Graz and Tübingen.Building on the strong background in proteomics biomarker discovery of ETH Zurich and Philochem, an innovative methodology (“HLA-peptidome analysis”) will be utilized for gaining information on the immune response in animal models and patients which receive antibody treatments. This method is based on the observation that HLA molecules in complex with peptides can be detected in the patient blood and that hundreds of HLA-associated peptides can be sequenced by mass spectrometry. The technology will be used for the profiling of responses following antibody treatment for patients with cancer and rheumatoid arthritis, as well as animal models of transplant rejection. This systems biology approach has the potential to revolutionize patient stratification in very short time.Finally, patient selection strategies will be investigated using th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Investigation of aberrant DNA methylation in malignant haematopoiesis' to be submitted under Horizon 2020.

assistant: **Abstract**

Acute myeloid leukaemia (AML) is an aggressive type of blood cancer characterized by uncontrollable growth of immature myeloid cells. Somatic mutations in diverse transcriptional regulators result in aberrant epigenetic landscape in leukemic cells, including patterns of DNA methylation. Due to its reversible nature, this epigenetic mark has been a promising therapeutic target and DNA methyltransferase inhibitors are already being used with varying degrees of success in clinic. The targeted improvement of existing therapies requires a better understanding of mechanisms how altered DNA methylation promotes malignancies. TET2, an enzyme catalysing DNA demethylation, is one of the most frequently mutated epigenetic regulators in AML. Its loss leads to hypermethylation at distal regulatory regions (or enhancers) and increased stem cell self-renewal and leukaemogenesis in the haematopoietic system. In the proposed work I plan to investigate the link between aberrant hypermethylation at enhancers and its role in developing and maintaining AML. Firstly, I will take advantage of clinically relevant AML mouse models that combine TET2 deficiency with AML-specific alterations and annotate DNA methylation-sensitive enhancers using high-throughput sequencing methods (MethylC-seq, ATAC-seq and ChIP-seq). Secondly, I will perform a positive-selection CRISPR-based high-throughput enhancer screen to identify DNA methylation-sensitive enhancers that inhibit leukemic stem cell self-renewal (i.e. tumour suppressive regulatory regions). Finally, I will identify and study the function of transcription factors which binding is lost due to aberrant DNA hypermethylation at these sites. The proposed work will be both discovery-based (genome-wide level) as well as mechanistic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Knowledge, Skills and Attitudinal Competences for Quality Early childhood Education and Care' in the context of a Horizon 2020 call.

assistant: **Objectives**

The education and training of the Early Childhood Education and Care (ECEC) workforce is of prime importance as it equips practitioners with the knowledge, skills and attitudinal competences needed to work with children. Training supports them in creating quality environments for children to enhance the quality of provision and subsequent child outcomes. The research is timely with the increased interest in the benefits of quality ECEC for supporting the holistic development of children, but with a need to understand more about the role of the workforce in this. Whilst qualifications have been established as important for the quality of ECEC, little is known about the nature of the qualifications and the role that they play in developing the knowledge, skills and attitudinal competences needed to best enhance the quality of ECEC provision. The research will focus on ECEC qualification requirements, structure, content and characteristics across Europe. The project will analyse (via secondary data) the qualification requirements across Europe, the composition of the qualifications and their relationship to child outcomes. This macro level analysis will be supported by a detailed investigation (via empirical research) into the delivery of qualifications and the role they play in developing the knowledge, skills and attitudinal competences appropriate to the context. The detailed investigation of qualifications will consider the formulation, delivery, experiences and application of ECEC higher education training in the host’s institution, selected for its expertise in training kindergarten pedagogues in Hungary. ECEC in Hungary is under explored, whilst also offering an interesting case to study due to how its history, market composition and quantity of provision contrast w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Lower bounds for combinatorial algorithms and dynamic problems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project aims to establish the time complexity of algorithms for two classes of problems. The first class consists of problems related to Boolean matrix multiplication and matrix multiplication over various semirings. This class contains problems such as computing transitive closure of a graph and determining the minimum distance between all-pairs of nodes in a graph. Known combinatorial algorithms for these problems run in slightly sub-cubic time. By combinatorial algorithms we mean algorithms that do not rely on the fast matrix multiplication over rings. Our goal is to show that the known combinatorial algorithms for these problems are essentially optimal. This requires designing a model of combinatorial algorithms and proving almost cubic lower bounds in it.The other class of problems that we will focus on contains dynamic data structure problems such as dynamic graph reachability and related problems. Known algorithms for these problems exhibit trade-off between the query time and the update time, where at least one of them is always polynomial. Our goal is to show that indeed any algorithm for these problems must have update time or query time at least polynomial.The two classes of problems are closely associated with so called 3SUM problem which serves as a benchmark for uncomputability in sub-quadratic time. Our goal is to deepen and extend the known connections between 3SUM, the other two classes and problems like formula satisfiability (SAT).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Paleobiogeographie et paleoclimatologie en vallee d'Aoste depuis la derniere glaciation d'apres l'analyse pollinique'.

assistant: **Objectives**

The vegetation history, during Late-glacial and Holocene in the Aosta valley is discussed using palynological data. There are no recent palaeoecological studies of this region. Cores were taken from 9 site situated at different altitudes. The palynological analysis will be supported by the study of macroscopic plant remains.  The aims of this investigation are : 1) to study the vegetation dynamic on a local scale and to compare the data to those for the Swiss and French Alps; 2) to describe the spatial and temporal difference of plant colonization at different altitudes since the Late-glacial; 3) to understand the role played by this region in the migration of taxa (such as Larix, Picea and Abies) after the Late-glacial; 4) to estimate the effect of the anthropogenic impact on the vegetation during the Holocene; 5) to use the results to understand the palaeoclimatology of the alpine region and to assess the possible consequences of the greenhouse effect on the reforestation of the mountain ecosystems. The results will be used for : 1) palaeoenvironmental and palaeoclimatic reconstructions; 2) reassessment of the biostratigraphy of chronologic and the anthropogenic pressure on the biosphere (deforestation and erosion); 3) relate the modern ecosystems to the past; 4) possible management of the biological resources using the historical data obtained; 5) global valutation of the consequences of a possible warming up of the atmosphere on the mountain ecosystems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Bioelectrochemical systems for metal recovery'.

assistant: **Objectives**

Global primary metal resources are rapidly dwindling and the mining and metallurgical industries are increasingly turning to lower grade minerals for metal extraction, typically increasing costs. Innovative environmental metal extraction techniques are required to increase mining sustainability, increase revenues and lower its impact on the environment. In this project, bioelectrochemical technology is proposed as an entirely new method for metal processing with the aim to produce marketable metal-containing (intermediate) products with low environmental impact compared to state-of-the art technologies.In bioelectrochemical technology, microorganisms catalyse the reaction occurring on one or both electrodes of an electrolytic cell. Such cells are called Microbial Fuel Cells (MFCs) when power is produced and Microbial Electrolysis Cells (MECs) when power is required to drive the desired reaction. Recently, it has been shown that Cu2+ is reduced to metallic copper on the cathode of a MFC coupled to the biological oxidation of organic matter and with resulting electricity generation. The proof-of-principle MFC almost completely recovered the Cu2+ in its metallic form (decrease in concentration from 1 g/L to < 1 mg/L) and produced a maximum power density of 0.8 W/m2.Bioelectrochemical technology can be used for the base metals copper, nickel, iron, zinc, cobalt and lead, which are mined, processed and used in large quantities. These metals are ubiquitous in process- and waste streams from the mining and metallurgical industry and therefore application of bioelectrochemistry for these metals has a high impact.Compared to traditional techniques, the use of Bioelectrochemical technology allows high recovery efficiencies, increased metal selectivity and reduced use of energy wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photonics in Flatland: Band Structure Engineering of 2D Excitons in Fluorescent Colloidal Nanomaterials' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In PHOCONA we aim to develop a new class of highly fluorescent 2D and quasi-2D colloidal nanomaterials for solution-processed coherent light sources and ultrafast single-photon emitters. The 2D excitons are created in suspended semiconductor nanoplates with a thickness below 5 nm, and transition-metal dichalcogenide monolayers. Prepared by colloidal chemistry and liquid-phase exfoliation, respectively, they take advantage of both quantum confinement through their nanoscale dimensions, as well as dielectric confinement via the dielectric mismatch between nanomaterials and surrounding matrix. Via smart nanocrystal design, more specifically by exploiting novel synthesis methods that include asymmetric in-plane confinement potentials, anisotropic crystal structures, and lattice strain-induced band structure modifications in core/shell heterostructures,  the nanomaterials will be shaped toward efficient multiexciton and stimulated emission, as well as stable, blinking-free single-photon emission. The intrinsic 2D exciton properties will be further modified toward ultrafast exciton recombination by coupling the nanomaterials to small mode-volume plasmonic nanocavities, hereby placing them in a local photon density-of-states that will lead to a strong Purcell enhancement. The realization of cost-effective, energy-efficient and highly flexible light emitters, which can be synthesized and processed via methods that are scalable to large areas and volumes, forms an important milestone in the ongoing development of optical and quantum communications technology, as well as new lighting and display applications.


**Keywords:** nanoplates, colloidal synthesis, lasing, single photon emission, solution-processed nanocrystals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Atmospheric Characterisation of Exoplanets' (ACE).

assistant: **Concept**

This fellowship project aims at the development of Dr. David Ehrenreich's young career, focusing on the atmospheric characterisation of exoplanets. More than 500 planets have been detected around other stars during the past 15 years. It is now time to go beyond the exoplanet census and start determining the physical and chemical properties of these new worlds, understanding how they formed, assessing their ability to host and sustain life, and eventually, detecting signs of life elsewhere in the Universe. These fundamental questions can be addressed by observations of exoplanetary atmospheres, supported by theoretical modelling. The objectives of the project are milestones leading to the detection of life: (i) detecting new worlds suited for atmospheric characterisation and (ii) pushing atmospheric characterisation of exoplanets toward the lowest-mass exoplanets, including hot neptunes and super-earths. These objectives will also serve the preparation of the detection and atmospheric characterisation of habitable, Earth-like exoplanets. To achieve these objectives, the applicant will work at the University of Geneva Observatory (UniGE), the leading actor in exoplanet detection aiming at becoming a European centre of expertise in exoplanets with a strong involvement in atmospheric characterisation of exoplanets. The fellow will get involved in the on-going planet search projects within the Harps and SuperWasp consortia. He will use his expertise in the atmospheric characterization of exoplanets to study the properties of the exoplanets detected at UniGE with space, ground-based, and archival spectroscopic data. He will participate to the implementation of projects that will enable the detection of numerous characterisable Neptune- to Earth-mass exoplanets: the ground-bas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optimised Pest Integrated Management to precisely detect and control plant diseases in perennial crops and open-field vegetables' (OPTIMA).

assistant: **Innovation**

OPTIMA will develop an environmentally friendly IPM framework for vineyards, apple orchards and carrots by providing a holistic integrated approach which includes all critical aspects related to integrated disease management, such as i) novel bio-PPPs use, ii) disease prediction models, iii) spectral early disease detection systems and iv) precision spraying techniques. It will contribute significantly to the reduction of the European agriculture reliance on chemical PPPs resulting in reduced use of agrochemicals, lower residues and reduced impacts on human health. OPTIMA will optimize disease prediction models for downy mildew in vineyards, apple scab in apple orchards and alternaria leaf blight in carrots to envisage faster the possibility of disease outspread and developing advanced early detection methods based on spectral imaging and deep learning techniques to precisely localise and quantify the infection. It will evaluate and screen biological and synthetic PPPs for their combined ability to control the selected diseases and weigh the optimum dosage and application timing and identifying and characterize induced host resistance mechanisms to achieve higher and durable resistance. It will enhance and develop three innovative prototype sprayers (for carrots, apple orchards and vineyards) actuating different nozzle types and adopting variable rate control based on canopy characteristics, the pathogen dispersal and disease development. The holistic developed IPM system will be tested and assessed in field conditions with the three selected crops. The advanced sprayer prototypes and the monitoring system will be tested in real-time to record field efficacy and potential discrepancies from the expected effectiveness. OPTIMA will finally, assess health, environmental an