RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'INVESTIGATION OF THE GENETIC AND BIOCHEMICAL FEATURES UNDERLYING THE HIGHLY DIVERSE XENOBIOTIC HYDROCARBON CATABOLISM IN NOCARDIOFORM ACTINOMYCETES' under Fourth Framework.

assistant: **Concept**

The proposed research aims to study the structural, regulatory and metabolic features responsible for the extremely diverse xenobiotic catabolism of Rhodococcus. The genetics and biochemistry of naphthalene catabolism will be investigated by: ( 1 ) direct DNA cloning, sequencing and site-specific mutagenesis of genes, operon(s) and regulatory regions involved in naphthalene catabolism using innovative mobilizable cosmid vectors that Dr. Archer has developed for Nocardioform Actinomycetes which permit functional screening for entire catabolic pathways in the genetically compatible, but catabolically naive host Corynebacterium glutamicum; (2) biochemical studies of purified and/or overexpressed enzyme substrate ranges and kinetics coupled with crossfeeding experiments of mutants carrying specific gene knock-outs will be performed to investigate pathway specificity, carbon flux and cross talk between polyaromatic and monoaromatic catabolic reactions. Enzyme data will be integrated to produce a model for naphthalene catabolic flux. The protein structural data derived will be further analysed using computer aided homology mapping" techniques to locate functional important regions within key enzymes. Analysis of gene-regulatory elements will enhance our understanding of Gram-positive promoter structure and gene regulation under oligotrophy. Training content (objective, benefit and expected impact) The genetic and biochemical proposed research will augment my D.E.A./MSc training as a biochemical engineer. Additionally it will provide a thorough education in microbial genetics. On gaining a PhD, I intend to continue my research career, most probably in an applied research institute or company. Links with industry / industrial relevance (22) Dr. Archer has developed very strong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ab-initio adiabatic-connection curves for density-functional analysis and construction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Quantum chemistry provides two approaches to molecular electronic-structure calculations: the systematically refinable but expensive many-body wave-function methods and the inexpensive but not systematically refinable Kohn Sham method of density-functional theory (DFT). The accuracy of Kohn Sham calculations is determined by the quality of the exchange correlation functional, from which the effects of exchange and correlation among the electrons are extracted using the density rather than the wave function. However, the exact exchange correlation functional is unknown—instead, many approximate forms have been developed, by fitting to experimental data or by satisfying exact relations. Here, a new approach to density-functional analysis and construction is proposed: the Lieb variation principle, usually regarded as conceptually important but impracticable. By invoking the Lieb principle, it becomes possible to approach the development of approximate functionals in a novel manner, being directly guided by the behaviour of exact functional, accurately calculated for a wide variety of chemical systems. In particular, this principle will be used to calculate ab-initio adiabatic connection curves, studying the exchange correlation functional for a fixed density as the electronic interactions are turned on from zero to one. Pilot calculations have indicated the feasibility of this approach in simple cases—here, a comprehensive set of adiabatic-connection curves will be generated and utilized for calibration, construction, and analysis of density functionals, the objective being to produce improved functionals for Kohn Sham calculations by modelling or fitting such curves. The ABACUS approach will be particularly important in cases where little experimental information is avail
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reducing wind energy costs with a stronger, taller wind turbine towers made from wood modules' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In the next 10 years, European wind power capacity will double. To maximize energy output & turbine efficiency, one of the most promising innovations is high altitude wind power plants. By building taller towers, we can exploit up to 2x stronger winds, lowering the cost of energy.Modvion is a wood construction engineering company founded in 2016. Our mission is to develop & bring to market the next generation of cost-efficient tall towers for wind turbines in engineered wood – nature's carbon fibre. Modvion’s team grew constantly, with highly specialized people joining the team. This led to our first patent and, currently, another pending patent.We bring to market the first ever modular wind turbine tower made from laminated wood (LVL). Using Modvion technology, towers can be built, with a larger diameter base. This increases its strength, thus leading to taller & stronger towers. By using engineered wood such as LVL, we were able to develop a structure with 55% more strength than steel per weight.Modvion’s innovative tower comes in modules that are optimized for strength, ease of transportation & can be efficiently assembled at the installation site. This enables us to go well beyond 150 meters at costs by up to 40% lower resulting in a 6% lower cost of energy.Modvion is currently preparing the installation of a 30-meter prototype near Gothenburg, Sweden that will be used both as a demonstrator, as well as research basis for the development of other wind turbine components.In terms of environmental impact, our product shows a zero impact and, compared to alternatives, this impact goes well beyond other market alternatives. As a system made of wood, our turbine tower holds the CO2 captured by trees during their growth & trapped in the tower and can cut 2,000 tons of CO2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tropical rain forest diversification: a GLOBAL approach' (GLOBAL).

assistant: **Concept**

Tropical rain forests (TRF) are the most species rich yet highly threatened ecosystems on Earth. They play pivotal roles as global climate regulators and for human wellbeing. Their long term conservation is central for global climate mitigation and biodiversity conservation. Elucidating the evolutionary processes that underpin this immense diversity is critical for improved conservation actions. What evolutionary processes determine TRF diversity? How will human-induced species losses impact the evolutionary history of TRF? Time calibrated phylogenies retain the fingerprint of these patterns and are fundamental prerequisites to maximize the conservation of evolutionary history. However, global densely sampled robust phylogenies are lacking for TRF plants, significantly limiting our ability to properly address these questions. I will generate the largest most comprehensive datasets ever assembled for a major, ecologically important and species-rich pantropical model plant family: Annonaceae (~2500 species). First, I will test major hypotheses about TRF evolution at a global scale and what biotic and abiotic factors drove their diversification. Then, I will predict the impact of plant species extinction on the evolutionary history of TRF. Using the extensive network of European herbaria, I will reconstruct a robust time-calibrated complete species level phylogenomic tree of Annonaceae. I will compile massive morphological, chemical and geographical datasets for all species. Novel paleoclimatic data will be modelled through space at ten discrete periods over the last 100 million years. These data will then be integrated using innovative statistical macroevolutionary comparative approaches to answer the above questions at never achieved levels of precision. GLOBAL will prov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a novel production system for intensive and cost effective bivalve farming' (SHELLPLANT), addressing dissemination and exploitation.

assistant: **Impact**

The ShellPlant project proposes to develop a plant for closed production of bivalves (primarily high valued scallops and oysters). The plant will include a cultivating system for bivalves in an innovative rack system, an algae photo bioreactor and a feeding and water exchange system with intelligent controls. The coordinator company Bioframe has done several tests with a floating closed system for the nursery phase and grow-out of bivalves and the project will build on this promising early technology developments.  The proposed project will strengthen the 6,000 SMEs working in the European aquaculture sector and over 50,000 SMEs in our supply chain. The sector has a turnover of more than €2.5Bn pa providing occupation for more than 80,000 people mainly in rural and coastal areas with high levels of unemployment. The ShellPlant project will focus on improving the profit of European shellfish sector and initiate the process of enhancing the level of innovation and exploitation of technology, in order to dissolve the obstacles of today’s challenges of intensive shellfish production.  The shellfish farmers and the technology and service providers in the aquaculture industry are experiencing increasing non EU- competition, especially from Canada, New Zealand, Australia and Japan with regards to shellfish aquaculture technology. These high technological countries are focusing on innovation and product development to reduce shellfish production costs and increase the quality, and are increasingly focusing on the European market demand for seafood. In Europe, the fundamental issue is therefore the improvement and maintenance of competitiveness, productivity and durability of the aquaculture sector as a whole. Further development of the industry must take an approach where farmi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Application of in-vivo gene transfer to cardiovascular research'.

assistant: **Objectives**

- To maintain a European facility for the production of transgenic models of cardiovascular disease.- To provide access to the facility and its materials to participating laboratories for the investigation of gene regulation and function, with specific focus on those genes involved in cardiovascular homeostasis.The technology for introducing genes into the mammalian germline is widely used in many areas of modern biomedical research. The 'Transgeneur' programme has been running for 5 years and consists of a dual-centre central facility which provides optimal flexibility for collaborative projects and for overcoming technical difficulties. This programme supports a central facility to service the needs of European researchers actively engaged in, or wishing to engage in, the application of transgenic techniques to the understanding of cardiovascular disease, in particular hypertension. Through studies on the regulation of the genes involved in blood pressure homeostasis, it is expected that greater insights into the underlying mechanisms surrounding both normal and abnormal blood pressure control will be obtained. Whilst numerous laboratories routinely generate transgenic mice, the transgeneur programme provides one of the few facilities able to consistently generate transgenic rats. The flexibility to utilise both species enables researchers to more effectively design their studies. Due the expense and time involved in the production of transgenic animals, access to such facilities is severely limited for European research groups working on cardiovascular disease. Through the production and dissemination of transgenic strains the programme aims to enhance the efforts of individual laboratories both in the study of gene regulation and the development of disease models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards predictive computational platform for drug solubilization in the gastrointestinal tract' to be submitted under Horizon Europe.

assistant: **Abstract**

Improving the oral absorption of poorly water-soluble drug molecules remains one of the major challenges in the pharmaceutical industry.  A key bottleneck in this process is the solubilization of administered lipophilic compounds in the small intestines, where bile salts (BS) and lipids assemble into colloidal particles. Therefore, understanding the mechanisms and controlling factors of this process is critical for drug development.The advent of powerful supercomputers has enabled the integration of in silico techniques into the investigation of complex, realistic systems. However, no existing computational platform explicitly accounts for intermolecular interactions to predict drug solubilization in gastrointestinal fluids (GIF). In this project, I will employ coarse-grained (CG) molecular dynamics (MD) to characterize the particles in GIF, and develop a python based computational platform to predict drug solubilization. The time and size scales involved, and the complexity of multi-component systems, make CG MD the most appropriate modeling tool to my project. An important initial step will be the development of required molecular models within the widely used and state-of-the-art Martini 3 framework. This task will leverage mine and the supervisor’s expertise to fill an important gap in CG MD bile salts and drug parameterization, and will expand on its own the applicability of CG MD to entire new areas. I will simulate GIF containing all scales of micelles/vesicles/droplets that are experimentally detected but not yet computationally studied in the entire range. Finally, I will be able to follow the solubilization mechanisms of drug molecules in the created GI environments, also leveraging a non-academic placement with an important pharmaceutical partner. Ultimately,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'E-ferry – prototype and full-scale demonstration of next generation 100% electrically powered ferry for passengers and vehicles', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

E-ferry addresses the urgent need for reducing European CO2 emissions and air pollution from waterborne transportation by demonstrating the feasibility of a 100% electrically powered, emission free, medium sized ferry for passengers and cars, trucks and cargo relevant to island communities, coastal zones and inland waterways. The vessel will be based on a newly developed, energy efficient design concept and demonstrated in full-scale operation on longer distances than previously seen for electric drive train ferries (> 5 Nm), i.e. the medium range connections Soeby-Fynshav (10.7 Nm) and Soeby-Faaborg (9.6 Nm) in the Danish part of the Baltic Sea, connecting the island of Aeroe (Ærø) to the mainland.E-ferry builds on the Danish ERDF funded project Green Ferry Vision proving feasibility of the concept to be demonstrated and indicating significant potential impacts compared to conventionally fuelled ferries operating on the same medium range routes; energy savings of up to 50%, annual emission reductions of approx. 2,000 tonnes CO2, 41,500 kg NOx, 1,350 kg SO2 and 2,500 kg particulates.E-ferry is likely to be the one with the largest battery-pack ever installed in a ferry with a record breaking high charging power capacity of up to 4 MW allowing for short port stays. On top of being 100% powered by electricity, the innovative novelties of the E-ferry design concept and its expected impacts addresses flaws in current state-of-the-art by demonstrating a concept based on optimised hull-shape, lightweight equipment and carbon composite materials, ensuring reduced weight by up to 60% on parts replaced by composite elements. Approval of the use of carbon fibre-reinforced composite modules in E-ferry’s superstructure according regulation through material and fire testing also is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Deep Brain Neuromodulation using Temporal Interference Magnetic Stimulation' (TIMS) targeting Horizon Europe.

assistant: **Abstract**

Five out of ten diseases leading to long term-disability are related to the brain, including stroke, depression or dementia. Despite tremendous progress in neurotechnology, there is still no effective treatment option available for many brain-related disorders. A very promising approach to treat brain disorders uses transcranial electric or magnetic stimulation (TES/TMS) to directly influence brain activity related to specific symptoms. However, these methods are limited in their spatial resolution, specificity and ability to reach deep brain areas. The aim of the proposed project is to develop a technical and experimental proof-of-concept for a new non-invasive tool that allows for millimeter- and millisecond-precise modulation of neural activity in superficial and deep areas of the human brain. Capitalizing on temporal interference effects, the device will apply high carrier frequency magnetic fields through a pair of coils. By modulating their relative phase, the combined fields will induce a locally amplitude-modulated electric field in the brain. As neural tissue is insensitive to unmodulated high-frequency fields (>1kHz), but responds to low-frequency amplitude-modulated fields, only brain regions will be stimulated where the combined field is amplitude-modulated. Building on the resulting versatility of stimulation frequencies and waveforms, we aim at providing proof for cell-type specificity of such temporal interference magnetic stimulation (TIMS). Moreover, we aim at providing proof for the feasibility of targeting neural activity at millisecond-to-millisecond precision. Availability of such device offering high spatial resolution, depth selectivity, steerability, as well as closed-loop-compatibility and cell-type specificity would mark a major break-through f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Support IT solution for creative fashion designers by integrated software systems to collect, define and visualize  textile and clothing trends through innovative image analysis from open data' in the context of a Horizon 2020 call.

assistant: **Objectives**

The objective of the SOMATCH is to improve the competitiveness of EU SMEs in Textile and Clothing (T&C) and design focused sectors by the collection, definition and visualization by ad hoc interfaces of  fashion trends.  SOMATCH will provide creative designers with detailed and reliable trends estimations and forecasts of user acceptance. Its goal will be achieved by the creation of an innovative tool for the mining and visualization of large sets of unstructured data, related to the use and preferences of fashion products by consumers, supporting T&C companies quick reaction to the market dynamics and better adaptation of design to real consumers’ demand.SOMATCH faces this complex and challenging deal by the combined development and application of SoA advanced image analysis technology, unexploited and innovative in clothing and fashion, combined with social network analysis. Its results will be presented to interested end users by dedicated interfaces and instruments: mobile devices as well as ad hoc visualization tools will be explored for this purpose. The visualisation of the generated data will be performed from off-line statistics, generated after data processing, and by  new  real-time instruments for image collection and evaluation of designs.  They will be targeted also by the integration of the systems with new SoA mobile and wearable (for ex. Google Glass) devices to collect information and to visualise trend interpretation. This approach will open a vast field of new approaches for the fashion designers, supporting final users involvement into the whole trend evaluation and a close interaction with them.To reach this purpose Somatch consortium includes research centres expert in image and content analysis (TUM, UPC), software providers experts in data manag