RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Next-generation colorectal cancer microecosystems for the discovery of microbiome-driven immunotherapies in personalized settings'.

assistant: **Innovation**

Colorectal cancer (CRC) ranks among the most prevalent and lethal malignancies globally. However, efforts to translate CRC research findings into clinical advancements have been hampered by inadequate in vitro systems. Even the current gold standard organoid models remain severely limited as they lack the topobiological complexity required to fully capture CRC pathobiology ex vivo. Among other factors, their unsuitability to properly model the multifaceted interactions between CRC and its tumor microenvironment (TME) is particularly limiting, especially since the TME has emerged as an essential element to tumor biology. Crucially, while the TME is being successfully exploited for immunotherapy in many cancers, these therapies remain ineffective in more than 90% of CRC patients. Among the different components of the TME, the colon microbiota is particularly interesting for CRC tumor immunity as in vivo evidence indicates that it can regulate inflammation, modulate immune cell activity, and alter responses to immune checkpoint inhibitors. However, whether anti-tumor immunity can be enhanced through targeted microbiomal-based therapies in CRC patients not responsive to immunotherapy has not been approachable in vitro due to the lack of suitable models. Building upon our expertise in microfluidics, tissue engineering, cell biology, and multiomic technologies, we aim to develop a groundbreaking ex vivo platform capable of integrating complex lymphoid and microbiomal microenvironments in patient-specific tissue-engineered miniature colons. This TME-oriented cancer model will reconstruct functional interactions among diverse components of the TME with unparalleled pathophysiological intricacy. It will be primarily used to shed light on the cancer–microbiota–immune axis, aiming
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'GMO Risk Assessment and Communication of Evidence' (GRACE) under Seventh Framework.

assistant: **Objectives**

The project GRACE willa)elaborate and sustainably implement a transparent framework for the review of GMOs or GM food and feed effects on environment, socio-economics and health andb)reconsider the design, execution and interpretation of results of animal feeding trials as well as in vitro studies for assessing the safety of GM food and feed.The framework will create  high quality reviewing processes for different fields of GMO impact assessment and address the need for a well documented, transparent and sustainable representation of these reviewing processes. This will provide valuable and accessible information addressing  the main issues associated with GMOs and enabling risk assessors, managers, scientists and the general public to reiterate and update their evaluations and conclusions on GMOs.  It will adapt recently elaborated methodologies for (systematic) reviewing of the risk assessment information of GMOs and derived food and feed. The quality assessment for all reviewed papers and studies as well as the reviews conducted by the consortium, will be referenced by an open access database and “one-stop-shop” for data and information relevant to GMO risk assessment.Animal feeding trials and in vitro studies will clarify and compare the scientific added value of 90–day feeding trials with whole foods with advanced state-of-the-art analytical, in vitro and in-silico tools. Suitable animal GMO-feeding models will be investigated, that are based on European (EFSA) and international guidance, and the project will provide guidance for relevant, alternative in vitro cell-based approaches for specific topics within the overall food and feed safety assessment. Available standard or scientifically approved protocols form the basis of the investigations also in the case of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Catalytic Hairpin Assembly-based Point of Need Detection Device for Noroviruses'.

assistant: **Objectives**

CHAMPION aims to develop a rapid, point-of-need (PON) diagnostic kit for the detection of Noroviruses (NoV), one of the leading causes of foodborne infectious disease outbreaks. The main motivations to perform this work is to provide an easy-to-use, economically convenient and standardized NoV diagnostic kit with high specificity and sensitivity Currently, the most effective protocol is the real time PCR (RT-PCR) for  the detection of NoV from food matrices. However, RT-PCR assays are designed for use in well-equipped laboratories with sophisticated laboratory infrastructure and highly trained technicians, and are unsuitable for use in limited infrastructure of or in the field. The CHAMPION  aims to facilitates and development of, rapid and non-enzymatic nucleic acid amplification system employing catalytic hairpin assembly (CHA) reaction coupled with a paper strip that can detect NoV from food matrices. Thus, the CHAMPION incorporates the pre-concentration, CHA signal amplification, specific detection and signal visualization in a single miniaturized device. Thus, it can be anticipated that the long-term outcomes of the proposed work will deliver a novel, accurate, rapid and reliable diagnostic assay for the detection of NoV.


**Keywords:** point of care diagnostics, paper based diagnostic kit, DNA amplification, Noroviruses, Food pathogen detection,  Catalytic hairpin assembly, Nanoparticles based detection, Food-borne virus diagnostic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Promitil® - a new ‘smart’ nanomedicine for cancer chemo-radiotherapy.' (Promitil) targeting Horizon 2020.

assistant: **Abstract**

There were over 18M new cases of cancer worldwide in 2018, out of which about 3.7M were in Europe. To treat cancer, radiotherapy is increasingly used in combination with chemotherapy. Chemo-radiotherapy is a non-invasive approach for cancer local control, given within a reduced period time and with potential for complete cure of cancer. The key to enabling the full potential of chemo-radiotherapy depends on radio-sensitization, which means the degree of effectiveness of the anti-cancer agents used for chemotherapy that make tumour cell more sensitive to radiation therapy. However, radio-sensitizers, like Mitomycin-C (MMC), still need to be significantly improved to achieve a more effective and safe treatment of patients.LipoMedix has developed a novel nanomedicine (Promitil® ) for chemo-radiotherapy. It is a liposome formulation of a Mitomycin-C Lipid-based (MLP) prodrug of the anticancer agent MMC. Promitil® enables efficient delivery of MLP with rapid activation in tumour tissue, yet with improved safety profile because it becomes active only upon radiation. This results in a higher and safer radio-sensitization effect.LipoMedix is an Israeli pharma SME founded in 2011. Its team has been involved for more than 20 years in cancer drugs and therapies, and now its mission is deliver to a novel, efficient, and side-effect free liposome prodrug to improve patients’ quality of life, healthcare outcomes and reduce the economic healthcare stress of chemo-radiotherapy. The SME-I Phase 1 project perfectly suits the innovation’s current stage of development and overall business strategy allowing LipoMedix to check final specifications of Promitil®, establish sound business development and gain partners necessary for the Phase II study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Deciphering the Evolution of Galaxies and the Assembly of Structure: Probing the Growth of Non-Linear Structure in the Dark Universe with Statistical Analyses of Galaxy Surveys'.

assistant: **Innovation**

I propose to measure the growth of non-linear structure in the dark universe to answer two fundamental questions in cosmology: Is the Cold Dark Matter structure formation theory compatible with the galaxy distribution on group scales? Is the accelerating expansion of the Universe caused by Dark Energy? This frontier research probes two key components of our standard cosmological model. This study is fundamental for understanding structure formation and galaxy evolution, leading to possible ground-breaking changes in our comprehension of gravitational physics.I will tackle this ambitious research plan by exploiting my extensive knowledge of galaxy survey analyses and propose to critically test our standard model by measuring three key properties: the shape and evolution of the Cold Dark Matter halo mass function; the efficiency of galaxy formation in Local Group sized systems; the evolution of the growth of structure. To achieve those decisive goals, I will build the DEGAS Team, an inter-disciplinary unit dedicated to solve photometric and spectroscopic survey systematics, to develop optimal clustering statistics for imaging surveys and to create a large variety of state-of-the-art mock Universes to interpret the statistical analyses. The techniques developed will be applied to two world-leading galaxy surveys: GAMA, a multi-wavelength redshift survey of which I am a founder and co-PI, and Pan-STARRS PS1, a unique 3/4-sky imaging survey. Using innovative clustering statistics accounting for individual photometric redshift distributions and statistically robust methods for halo mass function estimates, my DEGAS Team will provide the ultimate test for structure formation models, gain key insights on galaxy evolution and present novel constraints on the nature of gravity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Back to the roots of data-driven dynamical system identification'.

assistant: **Objectives**

To obtain data-driven dynamic models for simulation, prediction, monitoring, classification or control tasks, in applications e.g. in Industry 4.0 and eHealth, most identification methods ‘solve’ an optimization problem, relying on some nonlinear iterative algorithm. Undeniably, too many heuristics prevail: What do we mean by ‘solved’?  Where did the algorithm converge to? Is the model globally optimal, unique and reproducible? To tackle these scientific deficiencies, we design a framework to deal with inexact data. We solve a longstanding open problem of least squares optimality in system identification: for polynomial dynamical models, the optimal model derives from an eigenvalue problem. Hereto, we generalize notions from Algebraic Geometry (multivariate polynomials), Operator Theory (model spaces), System Theory (multidimensional realization) and Numerical Linear Algebra (matrix computations). The first objective is to develop a mathematically rigorous realization approach that maps data onto new mathematical structures (multi-shift invariant projective subspaces). The second objective is to conceive a ‘misfit-latency’ framework to optimally map inexact data to these mathematical structures. We prove this to be a multiparameter eigenvalue problem. We expect breakthroughs in system theoretic characterizations of optimality (covering all existing methods), in the generalization to multiple input-output and multidimensional models and in finding the global optimum in the linear dynamic H2 model reduction problem.  The third objective is to implement matrix computation algorithms for the results of the first two objectives, to root sets of multivariate polynomials, to solve multiparameter eigenvalue problems and to isolate only the minimizing roots. We focus on matrix a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DNA traveling exhibition and science theatre' (DNA-TEST), addressing dissemination and exploitation.

assistant: **Impact**

We propose to develop a travelling exhibition on selected life science topics combined with a live science theatre performance. The exhibition takes the form of two family members travelling through Europe in a trailer. Inside the trailer, information on the life sciences and current research is presented on posters and various multimedia, integrated as much as possible into the trailer's standard furniture. More information is set up in a covered area outside the trailer. Leaflets on the variety of science topics addressed by the exhibition are available free of charge. Science on stage.The trailer stops at different locations where two actors perform a short live theatre linking everyday events to life sciences. The performances are to appeal to a 'broad audience' no prior knowledge of the biosciences is necessary. The actors will interact with the audience, creating a relaxing atmosphere, and holding the audience's attention with funny, real-life anecdotes. The audience will be entertained, while receiving information on the biosciences. The performances will stimulate people to look for more information and visit the exhibition, talk to the actors and take the brochures. The engaging nature of the performance offers an ideal opportunity to attract people who would otherwise never take the initiative to learn more about science.DNA-TEST will be present at events and summer festivals throughout Europe to reach out to members of the public who are totally unfamiliar with science and research. All age groups - including youngsters and senior citizens - are target audiences of the exhibition. Do-it-yourself travelling exhibition. To share and disseminate the results, DNA-TEST includes: the development of an 'exhibition kit' that is easy to integrate into a standard rente
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fast, Flexible, and Convenient: a simple insert system for the in situ NMR analysis of very fast reactions on a modern open-access FT NMR spectrometer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The project will involve further design and development of our methodology, developed under the ERC Advanced grant 'arylator', for variable ratio in situ stopped flow NMR. The methodology has recently been published and its power amply demonstrated in the deconvolution of the mechanism for CF3 transfer from Ruppert's reagent to electrophiles. The equipment that will developed and demonstrated under tenure of a proof of concept grant will reduce the dead time from 0.2 seconds to a matter of milliseconds whilst retaining the flexibility of our current system. Thus a standard walk-up NMR spectrometer can thus be used ad hoc for the analysis of very fast homogeneous reactions. This will be transformative for the mechanistic analysis of reactions, including catalysed and enzymatic processes, and will significantly enhance the commercial potential of the stopped flow NMR system.


**Keywords:** NMR, stopped-flow, synthesis, mechanism, catalysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Electromagnetic Brain Activity: A Novel Mathematical Approach' (BRAIN), addressing dissemination and exploitation.

assistant: **Impact**

The existing functional imaging techniques for the brain have excellent space resolution, but their time resolution is of the order of 1s, which is too slow for the study of the brain. The only non-invasive techniques with adequate time resolution are magnetoencephalography (MEG) and electroencephalography (EEG). The main reason that MEG is not yet established as an acceptable clinical technique is the lack of uniqueness, namely there exist many currents, which give rise to the same magnetic field.However, it has been recently shown that for the case that the brain can be approximated by a sphere, the current is uniquely determined from the measurements, provided that one assumes that it minimizes the integral of its square. Furthermore, the numerical implementation of the minimizing current has been tested successfully with real data. The basic limitation of the above result is that the brain is not a sphere. A realistic approximation of the brain is provided by a tri-axial ellipsoid and the main objective of the project is to extend the above result from the spherical to ellipsoidal geometry and to take into consideration the cerebrospinal fluid. Mathematical techniques to be used include expansion in terms of ellipsoidal harmonics and the technique of generalized transforms, which has been recently introduced in the literature. Graduate students and young researchers will be trained on these topics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MARine bioMass valorizAtion for fooD and fEed innovation' (MARMADE).

assistant: **Concept**

The MARMADE project aims to develop sustainable, high-value food and feed ingredients from marine biomass, focusing on crustacean residues (shrimp shells and blue crabs) and seaweed. The key objectives are to 1) establish efficient biorefinery processes for extracting ingredients (pre/postbiotics, vitamins, peptides, oligosaccharides, fats, emulsifiers, and digestibility enhancers); 2) develop innovative food and feed prototypes with improved nutritional and sensory properties; 3) ensure compliance with safety, sustainability, and regulatory standards, paving the way for future market uptake.To achieve these objectives, MARMADE will leverage advanced technologies, including Deep Eutectic Solvents (DESs), Supercritical CO2 extraction, dynamic high-pressure processing (e.g., microfluidization, high-pressure homogenization), wet milling, screw pressing, ultrasonication, and cavitation, to optimize extraction efficiency and maintain the purity of bio-based food and feed ingredients. Key ingredients will be validated through in vitro and in vivo testing, ensuring compliance with safety standards, while consumers’ and end-users’ insights will guide product design to ensure market acceptance, in a multiactor approach.MARMADE aligns with the RIA-05 topic addressing the need for sustainable, affordable bio-based food and feed ingredients. It supports the Circular Economy Action Plan and Zero Pollution Action Plan objectives by valorising marine resources and reducing reliance on petrochemical-based ingredients. The project contributes to the Farm to Fork Strategy by enhancing the nutritional profiles of food products and aligns with the EU Bioeconomy Strategy by fostering bio-based cascading extraction processes. Additionally, MARMADE promotes environmental sustainability by int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Advanced European lithium sulphur cells for automotive applications'.

assistant: **Innovation**

Li-ion batteries become a reality in the future vehicles, although they do not fulfil completely the demands of consumers. In this respect batteries with higher energy density are required. Lithium technology utilizing sulphur as a cathode is one of the optimal choices since it offers the possibility of achieving high-energy, long-life storage batteries with a potential low price. At present, the practical use is faced with two major problems: (i) a low intrinsic conductivity of sulphur and polysulphides and (ii) loss of active materials due to solubility of the intermediate products in the commonly used electrolytes. The low intrinsic conductivity can be overcome using improved electronic wiring. The occurrence of soluble polysulphides is reflected as a loss of the active material during the cycling and additionally soluble polysulphides are responsible for overcharging problem which lowers the energy efficiency. With an aim to have stable capacity retention with a good cycling efficiency it is important to find a suitable electrochemical environment for the lithium – sulphur batteries. Possible approaches are using polysulphide reservoirs with modified surfaces in the highly mesoporous conductive matrix. Proposed system with high surface area should enable weak adsorption of polysulphides intermediates allowing reversible desorption. This way a full utilization of the active material without significant losses can be obtained. In order to understand the influence of surface area and surface modification, including interactions between electrolyte and sulphur based cathode composite we need to have a reliable characterization techniques. In this respect different electrochemical, spectroscopic and physical characterization (in-situ or ex-situ) techniques can provide us