RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mitochondrial membrane reorganisation induced by tBid during apoptosis: cardiolipin and cytochrome c redistribution analysed by single molecule spectroscopy and microscopy', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

One of the main control points of programmed cell death affects the release of cytochrome c and other proapoptotic factors from the mitochondria. The detailed mechanism by which cytochrome c is completely and rapidly liberated to the cytosol is not yet well understood, but it appears to involve two steps: i) redistribution of the cytochrome c stored in the mitochondrial cristae and ii) selective permeabilization of the outer mitochondrial membrane. tBid, a proapoptotic protein of the Bcl-2 family, has been recently related to the lipidic reorganization that takes place at the mitochondria during apoptosis. Addition of tBid to mitochondria induces quick morphological changes, which interconnect cristae and make cytochromec available at the outer mitochondria l membrane.This activity seems to depend on interactions with the mitochondrial lipid cardiolipin, which, being an anchor to cytochrome c at the inner mitochondrial membrane, redistributes during apoptosis, and mediates the selective targeting of tBid to the outer mitochondrial membrane. Recently, it has been observed by epifluorescence microscopy that tBid induces the appearance of novel cardiolipin micro-domains in monolayers. Single molecule optical techniques have been applied to study raft-associated proteins and lipid mobility in vivo and in vitro.Fluorescence correlation spectroscopy uses the temporal dimension and constitutes a powerful tool to study lipid and protein dynamics in domain-forming membranes. It is the objective of this project to characterize the formation of cardiolipin enriched domains induced by the presence of tBid in connection with the process of mitochondrial cytochrome c redistribution that occurs during apoptosis, by means of fluorescence correlation spectroscopy and microscopy in membr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Redirecting glial progenitor fate to rebuild the injured Brain' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Over a million different cell types and billions of connections underlie brain function. While the embryonic brain glial progenitors generate this cellular diversity, in the adult brain progenitor competence becomes restricted to generation of few cell types. Thus, any attempt to repair the brain requires knowledge of the rules governing fate decisions within a damaged environment. We have shown that injury activates an inflammatory transcriptional signature in glial progenitors leading to exit from a dormant state. Excitingly, our recent data indicates that injury leads to demethylation of developmental enhancers in these glial progenitors too. In the regenerating zebrafish, activation of enhancers drives a transcriptional regenerative program. Yet, in rodents, despite enhancer demethylation by injury, transcription of a developmental program is missing. The overall goal of this project is to envisage ways to efficiently commission enhancers to re-direct lineage choices of glial progenitors towards re-establishing brain function following injury. Recent technological breakthroughs, including clonal lineage tracing, genome editing, and single cell “omics” combined with mouse genetics and injury models will allow (i) analysis of fate choices in the naïve and injured CNS (ii) study of how the chromatin landscape impacts transcriptional modulation of cell identity (iii) to finally design an integrated manipulation of the epigenome, transcriptome and environment for directed brain repair by endogenous progenitors.We follow a multidisciplinary approach combining cutting edge technology in functional genomics, developmental biology and translational research and leverage on a set of cutting-edge experimental platforms established in my lab and validated protocols that have le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Authoritative Implementation Guidance and International Cooperation to Support Training, Awareness Raising, and Capacity Building'.

assistant: **Objectives**

WAI-Guide, Authoritative Implementation Guidance and International Cooperation to Support Training, Awareness Raising, and Capacity Building, drives sustainable impact for more scalable and affordable digital accessibility solutions. WAI-Guide aims to:  • Provide authoritative implementation guidance and training, thereby growing capacities of available accessibility experts;  • Accelerate tooling support for accessible content authoring, thereby making it more cost efficient to create accessible content;  • Identify and address gaps in accessibility standardisation, thereby increasing the coverage of digital accessibility requirements.  WAI-Guide achieves these objectives by conducting its work as an integral part of the vendor-neutral environment of the World Wide Web Consortium (W3C). WAI-Guide draws together key expertise from industry, end-user representation, public bodies, research, and other fields, to develop core accessibility solutions that are internationally consensed and recognised as authoritative references.  WAI-Guide develops open, royalty-free resources for a variety of audiences, each having a role in digital accessibility. This includes accessibility trainers and educators, consultants and service providers; vendors, developers, and integrators of authoring tools and content management systems; and designers, developers, procurers, project managers, and others involved throughout accessibility implementation processes.  WAI-Guide is uniquely positioned and qualified to develop best practices for digital accessibility that are rigorously vetted through the open collaborative W3C Process, and that are harmonised with the authoritative interpretation of the internationally recognised W3C standards for accessibility.  WAI-Guide comes at an opportune tim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeted complete next-generation sequencing for companion diagnostics and personalized treatment of cancer' (SEQURE).

assistant: **Innovation**

Next-generation sequencing (NGS)-based genetic tests are at the forefront of the adoption of personalized medicine in cancer. However, current tests rely on the sequencing of short fragments covering only a fraction of the complete sequence of genes of interest. By missing clinically relevant genetic variants, including structural changes such as gene fusions, genetic diagnostics for personalized medicine is suboptimal and ineffective. There is therefore an unmet need for a cost-effective technology, providing the complete sequence information and enabling detection of all genetic variants relevant for therapeutic decisions. Dutch biotechnology company Cergentis has developed the proprietary TLA (Targeted Locus Amplification) sequencing technology platform, enabling targeted NGS sequencing of complete genes, across all gene regions (exons and introns) and all types of genetic variants (including structural changes) in a single rapid analytical procedure.Cergentis seeks to finalize the platform development for the analysis of tumor biopsies and validate customizable companion diagnostic kit, that will be offered to pharmaceutical companies to improve effectiveness of drug development in oncology clinical trials. Company will perform validation of a dedicated in-vitro companion diagnostic BRCA SEQURE kit, markedly improving diagnosis and personalized treatment of breast and ovarian cancer. The project will position Cergentis’ technology for a co-licensing agreement with a global diagnostic/pharmaceutical company to ensure effective large scale clinical implementation of the TLA-based in-vitro companion diagnostic kits.By closing the gap from lab to market, SEQURE project will accelerate the commercialization of a unique diagnostic technology answering an unmet need in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DIRECTORY BASED EDI CERTIFICATE ACCESS AND MANAGEMENT' (DEDICA) targeting Fourth Framework.

assistant: **Abstract**

DEDICA plans to offer EU electronic data interchange (EDI) operators in sectors like banking, data security arrangements for them to network with so-called open system and distributed services, like electronic mail, which at present rely on different security standards. The proposal will involve making the certification infrastructure now employed for authenticating electronic messages in open systems compatible with EDI certification. A shared infrastructure will result in economies of scale for service providers, satisfy the global service needs of EDI operators and give e-mail users secure access to EDI.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Memristive In-Memory Processing System'.

assistant: **Innovation**

Our project aims to develop a new computer architecture that enables true in-memory processing based on a unit that can both store and process data using the same cells. This unit, called a memristive memory processing unit (mMPU), will substantially reduce the necessity to move data in computing systems, solving the two main bottlenecks exist in current computing systems, i.e., speed ('memory wall') and energy efficiency ('power wall'). Emerging memory technologies, namely memristive devices, are the enablers of the mMPU. While memristors are naturally used as memory, these novel devices can also perform logical operations using a technique we have invented called Memristor Aided Logic (MAGIC). This combination is the basis of mMPU.The goal of this research is to design a fully functional mMPU, and by that, to demonstrate a real computing system with significantly improved performance and energy efficiency. We have identified four main research tasks which must be completed to demonstrate a full system utilizing mMPU: mMPU design, system architecture and software, modeling and evaluation, and fabrication.  Both memristive memory array and mMPU control will be designed and optimized for different technologies in the first objective. The second objective will deal with the different aspects of the system, including programming model, different mMPU modes of operation and their corresponding system implications, compiler and operating systems. For system evaluation, we will develop models and tools in the third objective in order to measure the performance, area and energy and to compare them to other state-of-the-art computing systems. Lastly, we will fabricate the different parts of the system to demonstrate the full system.Encouraged from our preliminary experimental r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A combined Cryo Electron Microscopy and mass Spectrometry approach for the structural and functional characterization of the URI-complex' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Here we propose a novel hybrid strategy for the structure determination of macromolecular complexes using a state of the art mass spectrometry (MS) and cryo-electron microscopy (EM) approach. This strategy allows for the accurate fitting of crystal structures into EM-maps, but also provides structural templates for the identification of macromolecular complexes within cryo-electron tomograms (CET) by pattern recognition. It promises to establish the critical link from structural analysis of isolated protein complexes to their observation in the cell. As a promising initial target for our investigations we chose the recently identified URI complex (unconventional prefoldin RBP5 interactor), a regulator in cell growth control that acts downstream of the target of rapamycin (TOR).The structure of the URI complex is unknown, although the crystal structures of the archaeal homologues of several of its components have been solved. Therefore, it is likely to form a striking jellyfish-shaped scaffold structure consisting of prefoldins (PDFs) with having RuvB-like helicases attached to it. To generate accurate fits of crystal structures into EM-maps, additional spatial information is advantageous. A novel cross-linking strategy using a bivalent isotope tagged chemical compound, in combination with MS can provide such information. It has been established in the host institution and allows for identification of the interface of interacting proteins at primary structure level.We plan to combine this technology with single particle cryo-EM and the fitting of crystal structures to resolve the structure of the URI complex to pseudo atomic level. In a second step, the structure of the URI complex will be used as a template to monitor interactions with the next neighbours in the signall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photoelectrochemical Solar Light Conversion into Fuels on Colloidal Quantum Dots Based Photoanodes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The efficient use of solar energy is vital for the future of our Planet and to ensure to the next generations our and evensuperior welfare standards. Photoelectrochemical water splitting is a promising way to convert solar light into storable fuels,such as H2. However, an ideal photoanodic material for the oxygen evolution half-reaction has not been identified yet.Technologies based on solution-processed colloidal quantum dots (CQDs) are promising for producing effectivephotoanodes because of their low manufacturing costs and the possibility of controlling the band gap of the material throughthe quantum size effect.The main scientific aim of the QuantumSolarFuels project is the preparation of photoanodes for water splitting based onCdSe, CdTe and CdSeTe CQDs and their protection against photocorrosion. The CQDs will be assembled in flat electrodeseffectively protected against photocorrosion and activated toward water oxidation through: a) the deposition of amorphousTiO2 and subsequent coating with metal based oxygen evolution catalysts or b) by direct coating them with the oxygenevolution catalysts.Further objectives are: 1) the identification of the optimal CdSeTe composition and CQDs size for the preparation of efficientphotoanodes; 2) the use of Cd-chalcogenide CQDs in solar cells and photo- and electro-catalysis for renewable fuelsproduction.Thanks to this action the researcher will become a World expert in these areas, in particular in the innovative use of CQDsfor photoelectrochemical water splitting applications.Taking full advantage of the complementary competences of the two involved research groups, the one at the beneficiaryinstitution expert in the fundamental chemical aspects of photocatalysis and the partner group more focused on theengineering and industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'RESearch Elevation on Integration of SOLar Technologies into MEDiterranean BUILDings' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The Mediterranean countries, including Jordan and Lebanon, face significant energy challenges which mainly emphasise their need to secure energy supply, to satisfy elevating electricity demand due to increasing demographics and economic development and protect the environment. These challenges weight more considering that Jordan and Lebanon have little indigenous energy resources. The exploitation of vast solar radiation of the Mediterranean countries could curb electricity demand and also provide a renewable source to generate power. In light of these facts, the proposed project aims at the enhancement of the capacities of two Mediterranean organisations, the National Energy Research Center (NERC) of Jordan and the Lebanese Association for Energy Saving & for Environment (ALMEE) in order to engage in high quality research, implement research projects and provide scientific services in the fields of a) technological integration of solar heating and cooling and PV technologies (grid-connected and stand-alone) in buildings, b) simulation models and optimization of solar heating and cooling systems and PV technologies into building operations and c) energy modeling and decision support regarding the energy planning in municipal and regional scale emphasizing the adoption of PV and solar thermal technologies in buildings and oriented to support energy policy formulation. The capacity build will be provided by the Centre for Renewable Energy Sources (CRES) and the Fraunhofer Institute for Solar Energy Systems (ISE) to the Mediterranean organisations. It will be targeted to improve scientific knowledge through secondments and training, recruit researchers, enhance equipment, create partnerships and disseminate at EU, Mediterranean, national and international level. The capaci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Exploring photoexcitation-induced dynamic evolution of the small molecule activation at point defects'.

assistant: **Objectives**

For the photocatalytic reduction of inert small molecules using nanomaterials, surface point defects (such as vacancies and heteroatoms) play an important regulatory role. In particular, promoting the activation of adsorbed molecules is directly related to the subsequent multi-step reaction. Traditional simulations mainly focus on the relationship between the ground state fixation model and activation, while ignoring the exploration of the influence of dynamic evolution of defects and molecules on the activation process in the photoexcitation environment. Through the combination of first-principles, many-body perturbation theory, ab initio nonadiabatic molecular dynamics, and experimental verification, we will explore the dynamic evolution and the mechanism of the adsorbed molecule activation process at point defects under photoexcitation. 1) We will study the relaxation process of photogenerated hot electrons at point defects, analyze the formation and evolution of transient and vibrationally excited states of adsorbed molecules, and expand the static activation based on the conventional ""acceptance-donation"" mechanism. Simultaneously, by exploring the spin state transition and exciton effect at the point defects, we will reveal their effects on the lifetime of molecular dynamic activation intermediates. 2) By studying the dynamic evolution of point defects under molecular adsorption and photoexcitation, we will clarify the regulatory effect of point defects in semi-stable states on the evolution of adsorbed molecular excited states. 3) We will explore the effect of liquid-solid interfaces on the dynamic activation process of small molecules under photoexcitation. The implementation of this project will help resolve many contradictions between the static mechanism an