RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing a molecular tool box for the detection and population genetics of Phytophthora species threatening European forests and other natural ecosystems' (PHYTOFOREST) targeting Sixth Framework.

assistant: **Abstract**

European forests and related ecosystems are under threat of destruction or serious damage from the plant pathogenic pseudofungus Phytophthora. Nine damaging species, 7 new to science, have been discovered in many parts of Europe, from the UK to Turkey, damaging native forests and riparian ecosystems. Usually, large trees, oak, beech and alder, are attacked but under storey plants are also affected. Changes wrought by Phytophthora threaten the integrity, health, biodiversity, flora and stability of forests and riverbanks. Monitoring disease, tracking its movement and determining biodiversity within Phytophthora will provide an improved understanding of the origins of the cluster and thus aid the development of sustainable prophylactic strategies. There is however a lack of suitable methodology for this task. The aim therefore is to develop a 'toolbox ' of molecular markers for some or all of these nine Phytophthora species in plants, soil and water. A.generic technique for detecting Phytophthora, currently under development, will be adapted to detect several/all of the species of interest simultaneously. In addition, a panel of co-dominant micro satellites and single nucleotide polymorphisms (SNP) and mitochondrial (tm) DNA markers, will be developed to study their population genetics and gene flow. An existing panel of markers, already developed for studies of P. infesting, the cause of the economically important disease late blight of potato and tomato, will be adapted for this study. Many of the present markers are located within conserved genes and should be transferable, with modification. The tactical goals are (1) To develop detection technology to detect all species of Phytophthora affecting native forests and other natural ecosystems in Europe, even when several
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Systems Biology, Artificial Intelligence and Advanced BiOtechnology Approaches to Improve Soil  BioREMediation'.

assistant: **Objectives**

The growing presence of hazardous compounds in the environment such as persistent organic pollutants compromises the health of ecosystems and humans worldwide. The spontaneous ecological recovery of contaminated sites is possible due to the action of biological agents, including plants and microorganisms. The exploitation of the capability of the latter to transform toxic contaminants into harmless end-products can lead to cheap and sustainable bioremediation alternatives. However, the significant knowledge gap on the molecular mechanisms and microbial species responsible for an efficient detoxification of specific pollutants in determined environmental conditions is a burden slowing down the development of efficient microbial assisted bioremediation technologies. BIOREM is an integrated action conformed by experts in microbial systems biology, artificial intelligence tools and environmental sciences that will work together to gain knowledge in the identification of responsible microbial metabolic routes within natural and synthetic consortia for the degradation of target contaminants. The project through inter-sectorial and multidisciplinary training and collaboration will investigate the synergetic effect of different and combined bioremediation strategies, such as bioaugmentation, bioestimulation and microbial-assisted phytoremediation, stablishing links between effective pollutants removal and the responsible microbial pathways. Predictive models for TPHs and PAH remediation will be developed using High-Perfomance Computing (HPC) and Artificial Intelligence to enhance the efficiency of bioremediation strategies by enabling the analysis of vast amounts of environmental data. The integration of the project information (key microbial players and environmental condition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intelligent Motion Control under Industry 4.E' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

IMOCO4.E targets to provide vertically distributed edge-to-cloud intelligence for machines, robots and other human-in-the-loop cyber-physical systems having actively controlled moving elements. They face ever-growing requirements on long-term energy efficiency, size, motion speed, precision, adaptability, self-diagnostic, secure connectivity or new human-cognitive features.IMOCO4.E strives to perceive and understand complex machines and robots. The two main pillars of the project are digital twins and AI principles (machine/deep learning). These pillars build on the I-MECH reference framework and methodology, by adding new tools to layer 3 that delivers an intelligible view on the system, from the initial design throughout its entire life cycle. For effective employment, completely new demands are created on the Edge layers (Layer 1) of the motion control systems (including variable speed drives and smart sensors) which cannot be routinely handled via available commercial products.Based on this, the subsequent mission is to bring adequate edge intelligence into the Instrumentation and Control Layers, to analyse and process machine data at the appropriate levels of the feedback control loops and to synchronise the digital twins with either simulated or real-time physical world. At all levels, AI techniques are employable.Summing up, IMOCO4.E strives to deliver a reference platform consisting of AI and digital twin toolchains and a set of mating building blocks for resilient manufacturing applications. The optimal energy efficient performance and easy (re)configurability, traceability and cyber-security are crucial.The IMOCO4.E reference platform benefits will be directly verified in applications for semicon, packaging, industrial robotics and healthcare. Additionally, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flight plan artificial intelligence assistant' under Horizon 2020.

assistant: **Concept**

Drones in Europe are a rapidly developing sector with enterprises increasingly using drones for their business and the EU Legislator giving EASA rulemaking responsibility for civil drones of any mass. The common rules have been developed and will be enforced from January 2021. The performance of flight operations requires the compilation of a safety risk assessment document, in particular, the SORA (Specific Operations Risk Assessment) established for drone operations and endorsed by EASA. Compiling this assessment is expertise intensive and time-consuming. Currently, EUSC supports this operation with a web service called SAMWISE that, however, still requires the manual gathering of a large amount of information and the satisfaction of several constraints. The project aims to integrate into the web-solution built by EUSC the Artificial Intelligence (AI) technology generated by the FET-OPEN GOAL-Robots project, allowing the search of solutions in highly-nonlinear search spaces. The new technology from GOAL-Robots will support the semi-autonomous search of a solution to formulate flight plans based on an interactive interface, that meets the user’s requirements (flight start/arrival points, drone available, pilot licences, etc.), the SORA requirements, and the GIS characteristics of the involved overflown territory/airspace. The project will accomplish a systematic validation of the integrated system by testing the acceptability and usability of the proposed technology by selected stakeholders through the wide stakeholder network of the consortium. Moreover,  business case refinement and focused dissemination activities will pave the way to the commercialisation of the produced service within the European drone market.


**Keywords:** Service for drone markets, drone flig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Interface-Control for Organic Devices' (ICONTROL).

assistant: **Concept**

The ICONTROL project relates to the field of organic (opto-) electronic devices. We address the key components that determine device functionality and efficiency, i.e., the inherently existing interfaces between dissimilar materials in devices.The objectives of the project are:- Development of universal modification schemes for interfaces involving conjugated organic materials to achieve an unprecedented level of interface control.- Demonstration of applicability of these schemes in devices.- Transfer of these schemes to industrially relevant processing.- Generation of new insight into interfaces comprising organic materials, to provide a solid foundation for the future development of molecular electronics.Specifically, our schemes will allow for systematic and continuous adjustment of energy levels at virtually all interfaces, in order to provide:- optimised charge injection/extraction barriers at organic/electrode interfaces.- optimised energy level offsets at organic/organic interfaces.The common principle of our interface modification scheme is the introduction of oriented dipoles resulting from charge transfer reactions between specifically designed organic molecules and electrode materials, or between covalently linked donor/acceptor systems. The applicability of the new molecular materials that will be developed within ICONTROL is not limited to one specific interface-type.On the contrary, one new molecule will be useful to control the energetics at a wide variety of interfaces, making them true multifunctional materials. ICONTROL brings together 5 leading experts from 4 European countries, in order to combine the full expertise and line of actions needed to achieve the objectives of this multidisciplinary research effort: organic synthesis, electronic and struct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modelling basis and kinetics of nanoparticle interaction with membranes, uptake into cells, and sub-cellular and inter-compartmental transport' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The prediction of biological (and in particular toxicological) impacts has, as its basic pre-requisite, the correct prediction of the sites of action and localization of the nanoparticle in living organisms. We have identified the need for a paradigm shift in modelling these properties for nanoscale objects. The interactions between bare particles and organisms (cells, biological barriers) is radically different in the presence of proteins and lipids derived from the biological environment (the ‘protein corona’). The bare particle characteristic is therefore insufficient to describe the system. Similarly, nanoparticles are trafficked and translocated between sites by active biological processes where traditional ‘equilibrium’ principles for small molecules no longer apply. NanoTransKinetics is firmly based on advanced high quality experimental data on the distribution of nanoparticles in cells, across barriers, and (more limited) in vivo.  We frame phenomenological models in a modular manner by abstracting the essential relevant principles of particle-protein (and matrix) interactions, cellular and barrier transport mechanisms of nanoparticles, fitting them to experimental data. More detailed models allow for explicit checking of mechanisms and movements of individual particles into cells and across barriers. Enormous amounts of experimental data are now available to validate the models. A predictive capacity requires only simple input data on particle, corona and similar characteristics. The basis of these claims has been checked in preliminary studies, and a limited number of interactions, particles fluxes (and control parameters) between prescribed sites are sufficient to specify the system at each level of description. Resources (reaching far beyond the program itse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'COntext-informed AUtomaTic cHemical prOcess geneRation'.

assistant: **Objectives**

Improving the efficiency and resilience of the chemical and pharmaceutical industry is pivotal for the EU; in this frame, process flow diagram (PFD) design and retrofitting play a crucial role. Currently, it is executed by engineers leveraging their knowledge and engineering context, using a time-consuming iterative approach. On the other hand, AI-driven PFD design has proven outstanding capabilities in generating new process configurations. Despite being a promising technology, current approaches rely on training a new model when designing a process without leveraging process engineering information. Inserting such information would give the agent the optimisation context, improving the efficiency of the generated PFD and removing the need for retraining on each new design. However, such an integration requires investigating the best approach to inform the agent in the engineering context. This action wants to fill this gap by using a multidisciplinary approach combining reinforcement learning (RL) with chemical process optimisation and chemical properties predictions. The main project outcome is an AI agent able to design PFDs and retrofit existing ones without retraining while informed of the design aim and engineering context. The project will investigate the most suitable techniques for integrating chemical components and reaction properties into RL training for PFD design and retrofitting. The results of CoAUTHOR will advance our understanding of context-aware RL for chemical applications and generate an extensive toolkit for AI-driven PFD generation, paving the way toward a more sustainable and resilient chemical industry. In this action, I will combine my background in AI application in the chemical industrial domain with the expertise of the host research group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regulation of DNA damage responses at the replication fork' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project aims at delineating the regulatory signaling processes that enable cells to overcome DNA damage during DNA replication, a major challenge to the integrity of the genome as the normal replication machinery is unable to replicate past DNA lesions. This may result in collapse of the replication fork, potentially giving rise to gross genomic alterations. To mitigate this threat, all cells have evolved DNA damage bypass strategies such as translesion DNA synthesis (TLS), involving low fidelity DNA polymerases that can replicate damaged DNA, albeit in an error-prone manner, offering a trade-off between limited mutagenesis and gross chromosomal instability. How DNA damage bypass pathways are regulated and integrated with DNA replication and repair remain poorly resolved questions fundamental to understanding genome stability maintenance and disease onset. Regulatory signaling mediated by the small modifier protein ubiquitin has a prominent role in orchestrating the reorganization of the replication fork necessary for overcoming DNA lesions, but this involvement has not been systematically explored. To remedy these gaps in our knowledge, I propose to implement a series of innovative complementary strategies to isolate and identify the regulatory factors and ubiquitin-dependent processes that promote DNA damage responses at the replication fork, allowing for subsequent in-depth characterization of their roles in protecting genome integrity by targeted functional studies. This project will enable an advanced level of mechanistic insight into key regulatory processes underlying replication-associated DNA damage responses that has not been feasible to achieve with exisiting methodologies, providing a realistic outlook for groundbreaking discoveries that will open up ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Long Intervening Noncoding RNAs (lincRNAs): Developmental Functions and Molecular Mechanisms of Action' (FLAME).

assistant: **Innovation**

Genome-wide studies have revealed that the majority of vertebrate genomes are transcribed and generate large numbers of long intervening noncoding RNAs (lincRNAs). While there is growing evidence that these molecules have functional importance for diverse cellular processes, such as dosage compensation, transcriptional regulation, and reprogramming, the role of lincRNAs in normal development remains elusive. To better understand the function and evolution of lincRNAs, we previously identified over 550 lincRNAs expressed during zebrafish embryonic development. We demonstrated that at least two of these novel lincRNAs, megamind and cyrano, are required for proper embryonic development, in particular for brain morphogenesis and neurogenesis. Remarkably, lincRNA functionality is retained in mammalian orthologs despite rapid evolution and little sequence conservation between human and zebrafish lincRNAs (Ulitsky*, Shkumatava* et al., Cell, 2011).This proposal aims to identify conserved developmental functions of novel lincRNAs and to determine the molecular mechanisms that drive these lincRNA functions (Aims 1 and 2). For mechanistic studies, the initial focus will be on cyrano and megamind. Preliminary evidence suggests that one of these novel molecular mechanisms is through a non-canonical interaction between cyrano and the miRNA pathway (Aim 3). Furthermore, we will investigate the relationship between conserved genomic positions of lincRNAs across vertebrate genomes and their conserved biological functions (Aim 4). The specific aims outlined in this proposal will identify novel regulatory RNAs with important and potentially conserved roles in vertebrate embryonic development, and provide mechanistic insights into how specific lincRNA contribute to normal development. Mor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Magnon propagation in two dimensional magnets' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Two-dimensional (2D) materials, are crystalline planar structures with weak out-of-plane van der Waals (vdW) forces. Such 2D materials are often associated with extraordinary electronic, optical, and thermoelectric properties, such as extremely high mobilities. Ever since the isolation of graphene, the first 2D material, by Novoselov and Geim in 2004, the family of 2D materials have expanded by hundreds. However, long-range ferromagnetic order is typically not sustainable in 2D due to enhanced fluctuations. Consequently, 2D vdW magnets was only realized as late as 2017. Hence, it was only recently feasible to conduct elusive experiments for exploration of ground states, fundamental excitations and propagation of spin waves. Magnons, which are a quanta of spin waves, are particularly interesting to investigate in these 2D vdW magnets. In 2D, they exhibit step-like function of density-of-states as opposed to a gradually increasing function in three dimensional magnets. Meanwhile, other remarkable discoveries in these 2D vdW magnets such as a giant tunneling magnetoresistance has also been reported to be in close relation with magnon physics. The proposal aims to pursue seminal work in magnon excitation and propagation in 2D vdW magnets and leverage the outcomes to preposition next-generation of electron devices. So far, no report exists in quantifying magnon propagation length in a true 2D material (one or a few monolayers). On the technological front, using magnons instead of electrons to carry information in electronic devices would provide a significant low-power alternative to the existing technologies. The other highlight of this proposed device is the use of electrical signal for both injection and detection, allowing easier integration with electronics components.