RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Piezoelectric nanohybrid scaffolds for bone regeneration' (PIEZOSCAFF).

assistant: **Innovation**

Bone tissue regeneration remains an important challenge in the field of orthopaedic and craniofacial surgery and sees a transplantation frequency second to that of blood. The total number of bone graft surgeries performed each year worldwide to repair bone defects in orthopaedics and dentistry is more than 2.2 million. Current clinical treatments for critical-size defects are challenging, and despite the natural capacity of bone for healing, if an injury is beyond a critical limit (critical size defect), it cannot heal by regeneration. Bone grafting is the current standard treatment; however, given the inherent limitations of this approach, bone tissue engineering and advanced biomaterials that mimic the structure and function of native tissues hold potential as a promising alternative strategy. Nanocomposites containing hydroxyapatite have attracted attention as they are structurally similar to natural bone and provide an osteoconductive matrix to which bone can react with ‘bone’. However, nanocomposites do very little to assist in the recruitment of host cells to assist in bone repair. To circumnavigate this issue, we propose the incorporation of piezoelectric nanofibres to promote guided cellular infiltration. At sites of bone fracture, naturally-occurring electric fields exist during healing which promote cell migration and may become perturbed at sites of critical bone defects. Our aim is to develop a novel hybrid material that consists of a biodegradable bioactive hydrogel network containing hydroxyapatite nanoparticles and PVDF(TrFE) nanofibres to produce a scaffold with mechanical and electrical properties akin to bone. In this study, the hybrid material will be fully characterised pertaining to its morphology, chemical composition, mechanical stability and piez
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Bidirectional neuromuscular interface based on associative plasticity for stroke therapy during activities of daily living'.

assistant: **Innovation**

Stroke is a leading cause of disability globally, with millions affected each year. A critical challenge in stroke recovery is the limited availability and intensity of rehabilitation therapies, which often fail to meet recommended guidelines. The neubond device, aims to address this by delivering autonomous, wearable therapy to stroke survivors during their daily activities. The device detects muscle activity through muscle signals and provides real-time stimulation to enhance motor recovery. By leveraging our novel volition induced paired associative stimulation (VIPAS) approach, the system stimulates neuroplasticity and facilitates muscle contractions, accelerating functional improvements without the need for complex setups or screen-based exercises. Initial trials have demonstrated significant improvements in motor function and usability, with a reduction in spasticity and increased range of motion. Our concept aligns with the unmet need for continuous, accessible rehabilitation, bridging the gap between clinical and home-based care. The device non-invasive, autonomous design enhances patient compliance, ensuring consistent therapy outside of scheduled sessions. The project leverages findings from the ERC Synergy grant Natural BionicS, focusing on bi-directional brain-muscle interfaces. The project aims to advance the prototype towards regulatory compliance, safety, and usability testing, ultimately driving commercialisation and spinout formation. Our device presents a high-gain potential, with significant cost savings for healthcare providers and enhanced quality of life for stroke survivors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Governance of Educational Trajectories in Europe. Access, coping and relevance of education for young people in European knowledge societies in comparative perspective' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The GOETE project will analyse the role of school in re-conceptualising education in terms of lifelong learning by combining a life course and a governance perspective. In European knowledge societies adequacy of education means a balance of individual, social and economic aspects. This is operationalised by exploring how educational institutions conceptualise and organise individual educational trajectories. The study covers the period from transition into lower secondary education to transition into upper secondary education/vocational education and training, i.e. the age group between 10 and 16 years. Comparative analysis will focus on the regulation of access to education, of support measures for coping with education and of securing the relevance of education for social integration and the labour market. In 8 EU countries the mixed-method study involves surveys with students, parents and school principals; comparison of teacher training; case studies of local school spaces; discourse analysis; expert interviews with policy makers and stakeholders. On a scientific level, the comparison of the regulation of educational trajectories involves re-conceptualising the social aspects of learning and education under conditions of late modern knowledge societies. It reflects the need for formal education to be embedded in social life worlds, enabled by social support, and complemented by informal and non-formal learning. On a practice and policy level, it will provide information about alternative means of providing children and young people with access to education; of supporting them in coping with education and ensuring the relevance of education by communication and cooperation between school, labour market, other educational actors, students and parents. The communicati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Discrete random geometries: from solid state physics to quantum gravity' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

A comprehensive training program for the young postdoctoral researchers hired by the network sites will be instituted, consisting of short courses and instructional seminars from various team members. This is in addition to the 300 person months of research by training that has been budgeted for and will be carried out in the various teams which all have acknowledge expertise in their fields. We are fortunate to have access via two of the teams to the facilities of the Albert Einstein Institute (AEI) in Germany and the International Centre for Mathematical Sciences (ICMS) in Edinburgh that are well suited to a regular program of such meetings. It is also intended that post-docs hired by the network will spend extended periods at various sites other than their base site to further their training and acquisition of useful research techniques. Dr Renate Loll of the AEI will have special responsibility for encouraging the participation of women postdoctoral researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Broadband Integrated and Green Photonic Interconnects for High-Performance Computing and Enterprise Systems' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Big Data requires Big Pipes. Driven by mobile devices, cloud computing and machine-to-machine Internet, the amount of data processed by data centres continues to grow with a steep progression. Ongoing trends in server virtualisation and green computing morph the data centre architecture and place increasing constraints on the interconnect technology. To meet the need for increased bandwidth, transceiver compactness, reduced power consumption and cost effectiveness for the next generation of data centre and campus-wide communications systems, we are going to develop Broadband Integrated and Green Photonic Interconnects for High-Performance Computing and Enterprise Systems (BIG PIPES). BIG PIPES will reach the industry target of 400 Gbps transceiver modules with a highly integrated technology aiming at aggressively extending the limits of compactness, power consumption (below 30mW/Gbps) and cost-effectiveness, with the objective of providing an optical engine for future 12x25 Gbps CXP and 16x25 Gbps CFP4 modules. To deconstrain the switch board architecture, we will package these optical engines in mid-board optical modules. High campus-wide data throughput is expected to be pivotal in supporting growing data-centre dimensions, as well as modularity in data centre architectures. To enable ultra-broadband transceivers optimally utilising a single integrated light source, we will develop spectrally efficient links reaching 1 Tbps and above. The developed communication system technologies will leverage integrated, mode-locked comb sources to allow both compactness and novel system architectures. The research project will comprise the development of tailored comb sources, the exploration of novel system architectures, as well as the development of photonic devices and assembl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nonlinear analysis for virtual design of composite deployable space booms and membranes' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

NOVITAS aims to generate novel advances in the mathematical modelling of deployable and ultra-thin structures. They consist of booms and membranes that are first flat and coiled around a cylinder, and then they passively deploy, releasing the elastic strain energy stored during the furling phase. During history, deployable structures were adopted for various space applications, for instance, for telescopes, photovoltaic surfaces and antennas. The adoption of deployable booms allows larger structures to be easily and efficiently packaged for launch and reliably deployed on orbit. Despite the reliability of this kind of structure, there are still some issues to be tackled, including the development of a mathematical model able to deal with the accurate definition of the multiscale three-dimensional stress state and failure identification, the material viscoelastic effects, the effects of new composite materials and the multibody simulation for the deployment phase. We will address these issues with an innovative and interdisciplinary approach that combines theoretical, numerical and experimental investigations. The mathematical models formulated by NOVITAS will be able to accurately describe the nonlinear (mainly geometrical) behaviour that this kind of structure typically show during their services, whereas current models fall short due to their time-consuming analyses. We will compare and validate the numerical results with those obtained by experiments, which consists of the creation of a prototype at the Space Structures Laboratory at Caltech, for the viscoelastic and thermal multiphysics testing and simulation of deployment phases to be simulated with a multibody approach. The developed modelling technique will provide engineers with an efficient way for the design o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'REGULATORY T CELLS AND TISSUE DAMAGE CONTROL' (REGDAM), addressing dissemination and exploitation.

assistant: **Impact**

Regulatory T cells (TREG) are critical players in the control of innate and adaptive immune responses while impacting as well on the functional output of parenchyma tissues. This later effect is exerted by tissue-resident TREG, via an ill-defined mechanism that modulates tissue damage control, that is, a protective response of parenchyma tissues that limits cellular dysfunction and/or damage imposed by inflammation and immunity. The central hypothesis to be tested under this proposal is that tissue-resident TREG modulate tissue damage control via a number of adaptive responses to cellular stress, which preserve the functional outputs of parenchyma tissues. Failure of tissue-resident TREG to modulate adaptive responses to oxidative and hypoxic stress should exacerbate the deleterious effects imposed by these forms of stress on parenchyma cells and as such promote the pathogenesis of immune mediated inflammatory diseases. Under this Marie-Curie fellowship we will address mechanistically how TREG receive signals from tissues exposed to oxidative and hypoxic stress and migrate to those tissues to modulate oxidative and hypoxic stress responses as to dampen tissue damage.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular interactions of oncogenic marek's disease herpesvirus with its natural host and other viral pathogens' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

In a model of virus-induced lymphomatosis and its prevention by novel strategies of vaccination, unclear biological processes during infection of chickens with Mark's disease virus, such as molecular mechanisms of virus persistence, ontogeny transformation, its prevention by vaccination and interactions with other pathogens will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a compact, user-friendly and cost effective source for the generation of powerful and broad ultrashort pulses in the deep-UV' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Here we present an original design of a compact and portable set-up able to generate very broadband (70-100 nm at 300 nm) and powerful (>1uJ/pulse) ultrashort deep-UV pulses. Compared with other schemes, it guarantees an aberration-free propagation, an easy installation and minimal dispersion. The present project aims to bring the current prototype to the level of a commercial device. The conceived design will allow to manufacture a compact, portable and cost effective device, which will be user-friendly and with almost no required maintenance. There is no such a source commercially available and the schemes proposed in scientific literature require an advanced level of competence in optics and laser physics, are not cost effective and unsuitable for industrial applications. There is thus a need of sources for ultrafast broadband radiation in the deep-UV to advance and enable new ultrafast science and extend into this spectral range the technological application of ultrafast laser sources. The implementation of the proposed device will definitively fill this gap.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Accelerated Development of Appropriate Patient Therapies: a Sustainable, Multi-stakeholder Approach from Research to Treatment-outcomes - Sofia ref.: 115890'.

assistant: **Innovation**

Progress in the life sciences and related technologies offer great potential for therapeutic benefits to patients in need. However, major adaptations to current paradigms of bringing medicines to patients are required in order to realize that potential and to address important challenges in the healthcare ecosystem.Against this background, several initiatives are exploring new pathways to market, collectively referred to as Medicines Adaptive Pathways to Patients (MAPPs).The ADAPT-SMART consortium is aligning a limited number of major stakeholders eager to progress towards MAPPs implementation. It will act as a neutral collaborative platform that will engage industry, SMEs, regulators, Health Technology Assessment bodies (HTAs), payers, governments, clinicians and patients.The ADAPT-SMART consortium will contribute to align understanding of the impact of MAPPs, to share learnings between all stakeholders, and to allow the field to actively work towards MAPPs implementation.The impact of the ADAPT-SMART CSA will be a result of the delivery of• actionable advice/recommendations to IMI on how to best leverage results from past/current projects;• concrete proposals for future (IMI) projects;• actionable advice/recommendations and information to other actors in the healthcare environment;• synthesis of learnings from pilot projects and case studies with relevance to MAPPs;• communication of CSA outcomes by way of publications and conference presentations.This CSA will increase the probability of successful implementation of MAPPs and accelerate access to crucial therapies, thus improving the position of both the patients in need of novel treatments and the research-based pharmaceutical industry.


**Keywords:** Adaptive design, regulatory, HTA, reimbursement, R and D models,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'NAnostructured Surface Activated ultra-thin Oxygen Transport Membrane' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main objective of the proposed project is the development and industry-driven evaluation of highly stable and highly oxygen-permeable nano-structured oxygen transport membrane (OTM) assemblies with infinite selectivity for oxygen separation from air. The new approach proposed to reach this objective is the development of ultra thin membrane layers by e.g. CVD, PVD or Sol-Gel techniques with catalytic activation of the surfaces. This approach is supposed to make available highly stable membrane materials, which are currently out of discussion as the oxygen permeation measured on thick membranes is too low. Sufficiently high oxygen fluxes shall be obtained by (i) ultra thin membrane layers on porous supports to minimize diffusion barriers; (ii) catalytic surface activation to overcome slow surface exchange/reaction kinetics; and (iii) thin-film nano-structuring, generating new diffusion paths through the grain boundaries in a nano-crystalline matrix. The membrane development is supported by thermo-mechanical modelling as well as atomistic modelling of transport properties. The produced oxygen is provided to Oxyfuel power plants or chemical processes such as oxidative coupling of methane (OCM) to higher hydrocarbons or HCN synthesis, which will contribute in a way to the mitigation of CO2 emissions. Oxyfuel power plants combust fuels using pure oxygen forming primarily CO2 and H2O making it much easier and cheaper to capture the CO2 than by using air. The major advantages of OTM are significantly lower efficiency losses than conventional technologies and the in principle infinite oxygen selectivity. OCM produces higher hydrocarbons directly without forming CO2 and HCN synthesis can be improved by process intensification resulting in energy and subsequent CO2 savings.