RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Secure Hardware with AdvaNced NONvolatile memories' (SHANNON) under Horizon Europe.

assistant: **Objectives**

Over the recent years, the explosive growth of digital technologies allowed to implement disruptive business models driven by data collection and processing. In particular, the internet of things (IoT) opens unprecedented opportunities for consumers (smart society), organisations/companies (industry 4.0/ smart factories) and governments (smart nations). However, as every adoption of new technologies involves some risks, security attacks are amongst the most severe challenges for IoT: only in 2021, the inflicted damages have been valued $6 trillion globally and 1,097 organizations were hit by ransomware attacks. Secure IoT is generally enabled by the physical unclonable function (PUF), namely a hardware function which is embedded in the chip and capable of generating a random, unique response to a given challenge. Improvements in attack methods over the years have recently moved the field of PUFs from the conventional, silicon-based CMOS technology, toward emerging non-volatile memories (NVMs). The latter allows for high density, low cost, highly scalable PUF with the capability of reconfiguration. Currently a truly tamper-resistant and reliable weak PUF leveraging stochastic switching of NVMs for secure IoT is still missing and highly requested by the market. Within the ERC-COG project RESCUE (2015-2020), a novel method for true random number generation (TRNG) based on NVMs was developed and patented. The TRNG scheme allows for iPUF (invisible PUF), namely a digital, highly reliable PUF, which is 100% robust to physical attacks. Within the SHANNON project, we will address the technical and commercial feasibility of iPUF, validating the concept with industry grade embedded NVMs and elevating its technology readiness level via experimental tests and simulations. New archi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Feasibility assessment of a cloud application platform for rational drug design using high throughput molecular dynamics' under Horizon 2020.

assistant: **Concept**

The pharmaceutical industry’s increasing spending on R&D is not translating into new and better drugs at the pace required to maintain competitiveness. In-silico computational methods are beginning to gain traction in the progress towards more rational drug discovery workflows. Among the methods available, molecular dynamics (MD) provides the most accurate and useful description of molecular interactions, but the current state of the art has both a high degree of unnecessary technical complexity, and is computationally expensive. Together, these two factors have produced a high barrier to entry that substantially limits research productivity.Acellera looks to address these issues by proposing a cloud application platform for high-throughput MD (HTMD) simulations.  This computational platform combines proprietary simulation technology - optimized for speed and simulation throughput – and user-friendly interfaces in a cloud environment to provide a novel resource for drug candidate identification.  HTMD, which allows understanding with an unprecedented degree of resolution and accuracy how drugs interact with their biological targets, can significantly reduce the cost of pre-clinical research (PCR) by virtualizing key steps.  It is currently estimated that pharmaceutical companies invest approximately 1000M Euro per approved drug.  As a global leader in the development of technology for high-throughput molecular dynamics, Acellera is uniquely positioned to bring this disruptive computational technology to the market. The HTMD platform is ready for prototyping in an operational environment (TRL 6).  Acellera proposes a Phase 1 SME Instrument to support the execution of a feasibility study into the market viability of the HTMD solution for pre-clinical research. Results of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Self-* Grid: Dynamic Virtual Organizations for schools, families, and all' (Grid4All), addressing dissemination and exploitation.

assistant: **Impact**

Grid4All aims to enable domestic users and non-profit organisations such as schools and small enterprises, to share their resources and to access massive grid resources when needed, envisioning a future in which access to resources is democratised and cooperative.  Examples include home users of image editing application, school projects like volcanic eruption simulations, or small businesses doing data mining. Cooperation examples include joint homework between pupils, or international collaboration.Grid4All goals entail a system pooling large amounts of cheap resources (connecting to commercial cluster providers when needed); a dynamic system satisfying spikes of demand; using self-management techniques to scale; supporting isolated, secure, dynamic, geographically distributed user groups and using secure peer-to-peer techniques to federate large numbers of small-scale resources into large-scale grids.We target small communities such as domestic users, schools and SMEs (for-profit or non-profit), harnessing their resources added to resources from operated IT centres, to form on-demand service oriented grids, avoiding preconfigured infrastructures. The technical issues addressed are security, support for multiple administrative and management authorities, p2p techniques for self-management/adaptivity/dynamicity, on-demand resource allocation, heterogeneity, and fault tolerance.The proof of concept applications include: e-learning tools for collaborative editing in schools and digital content processing service accessible by end residential users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Origins and Evolution of Artificial Cold in Europe, 1870-1970: Exploring Science/Technology/Industry Interfacing' to be submitted under Sixth Framework.

assistant: **Abstract**

The proposed research project focuses on the history of the science, technology, industry and cultural impacts of artificial cold, circa 1875-1970 in Europe. The field of artificial cold is of particular interest to historians and historical sociologists o f science, technology and medicine on two counts: it is a domain where science, technology and industry have often been closely linked, as well as a field in which European science, industry and technology have excelled. Moreover, it is a domain that invites studies of issues related to a number of social transformations brought about by the extensive use of artificial cold in the latter part of the 19th century, and especially during the first half of the 20th century.We aim to add to existing literature a new dimension through the examination of two fundamental historical and sociological themes: On the one hand, convergence between academic research, engineering, industry and their social repercussions; on the other, the pursuit for convergence between assertive national science and the internationalisation or Europeanization of science. The structure and dynamics of activities and evolution of artificial cold offer an exceptional window into these dual processes, with an abundance of to-data unexploited archival and published documents. In doing so, we will bring to the fore the elements that have ensured European hegemony in key industrial, engineering and academic activities in the field of artificial cold.Moreover, we will provide the means to examine how the tensions between national and European activities in the science, technology and industry of artificial cold have contributed in Europe's integration. The final outcome of the project will provide useful information and knowledge for policy makers and mana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deciphering the role of C2H2 zinc finger transcription factors during primate neocortex development and evolution' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The neocortex is a fascinating brain structure, as it is the seat of mammalian, and notably primate, higher cognitive abilities. In the primate lineage, different neocortex morphology, in form of size and folding differences, has evolved. The development of the neocortex, and particularly of the different neocortex morphology, depends primarily on the precise regulation of the activity and behavior of cortical neural stem and progenitor cells (cNPCs), a regulation that is primarily mediated by transcription factors. One of the largest transcription factor families is the C2H2 zinc finger transcription factors (C2H2-ZFTFs), which also significantly expanded during primate evolution. Previous studies suggest that these transcription factors could be important regulators of primate neocortex development and evolution. Here, I propose that differential expression of these C2H2-ZFTFs is one essential cause of the differences in neocortex morphology between different primate species. To address this hypothesis, I plan to first identify expression differences of C2H2-ZFTFs in cNPCs of different primate species by transcriptome analysis of fetal human, macaque, and marmoset neocortex. These differences will then be tested for a functional role in cNPCs using electroporation and stable genetic modification of brain organoids. Finally, for C2H2-ZFTFs with a functional role in cNPCs, the downstream gene regulatory network will be uncovered by identification of the indirect and direct targets using RNAseq and ChIP-exo of in vitro differentiated neural progenitor cells. This will lead to a better understanding of the role of C2H2-ZFTFs in the regulation of cNPCs, while also identifying their contribution to primate neocortex development and evolution that has led to different primat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Combined remote sensing and modelling approach to assess the past, present and future evolution of Alaska/Yukon glaciers (northwest North America)', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The arctic regions are expected to experience the most profound impacts of the ongoing global warming. Some alarming observations have recently been reported by the Arctic Climate Impact Assessment group, such as reduced sea ice cover or freshening of the Arctic Ocean. One of the most striking features is the rapid wastage of glaciers and ice caps. Improved knowledge of the evolution of these glaciers toward the end of this century is crucial as they significantly contribute to water resources, sea level r ise. We propose in this project to use a combined modelling and remote sensing approach to assess the past, present and future evolution of the glaciers and icefields of northwest North America with special emphasis of those in the Yukon (Canada) and Alask a (USA). This goal will be achieved through the development and validation of a new Regional land Ice Dynamics Model (RIDM). A two-step approach is planned:The first step of the project is the development and validation of the RIDM under the well known 20t h century climate forcing and glacier response. Remote sensing measurements will play a major role by providing:1. Boundary conditions for the model. In particular, we will develop a method to retrieve the subglacial topography in regions that are currentl y ice-covered using satellite-derived velocity fields.2. Tight constraints on model performance. We will test the capability of the model to reproduce the present day ice cover and ice flow dynamic.In a second step, we will run the RIDM under different cli mate condition. First, we will force our model with surface temperature and precipitation fields derived from paleoarchives, including ice-core climate records from Mt. Logan (5960 m asl) to study the evolution of the Yukon/Alaska glaciers during the Holo cene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fine Tuning the Final Common Pathway: Molecular Determinants of Motor Unit Development and Plasticity' (2007-2013).

assistant: **Innovation**

Motor neurons (MNs) constitute the final common pathway in the generation of behaviors by linking the CNS with the movement apparatus. Herein, MNs diversify into fast, intermediate and slow types whose properties are tuned to the speed, force and endurance of the muscle fiber contractions they elicit. The MN-muscle fiber units display marked plasticity towards chronically altered physical activity, and show strong differences in their vulnerability towards degenerative conditions affecting the neuromuscular system, including amyotrophic lateral sclerosis and aging. Despite their central importance for determining neuromuscular output, plasticity and vulnerability the molecular mechanisms determining the functional MN types remain unknown. My group will use a cross-disciplinary approach by employing molecular genetic, cell biological, electrophysiological and motor behavior assays in mouse and chick to dissect molecular pathways determining MN type status and their contribution to neuromuscular system function and plasticity. Based on our preliminary data, this will focus on the contribution of non-canonical Notch signaling to MN type-specification and neuromuscular function, in addition to four newly identified neural activity modulators as candidate effectors of motor unit output and plasticity. This will be complemented by screening additional pathway components for roles in determining MN type properties through newly developed rapid gene tagging and electrophysiological interrogation in chick, followed by addressing their requirement for motor unit specification and function in mouse. Through an iterative cycle of (i) investigating candidate determinants of motor unit type, (ii) defining their role and mode of action in motor unit specification and function in the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Topological, Algebraic, Differential Methods in Classification and Moduli Theory""' (TADMICAMT).

assistant: **Concept**

Moduli of curves with symmetries:determine the stable irreducible components of the moduli space of curves of  genus g with an action of a finite group G, using a new homological invariant. Stable means: for g sufficiently large, or for sufficiently large numerical branching function. Higher homological stabilization for these moduli spaces. Faithful actions of the absolute Galois group on moduli spaces of marked varieties, triangle curves, varieties isogenous to a product, Beauville surfaces. Change of fundamental group. Fields of definitions of triangle curves and the scheme representing triangle curves.Uniformization: characterization of proj. var. whose universal cover is a given bounded symmetric domain (Catanese-Di Scala did the case of tube domains). Orbifold Uniformization: where we have a quotient of a non free action, or a noncompact such  quotient. Classification of surfaces with genus 0 having the bidisk as universal cover. Symmetric differentials and fundamental groups of some ball quotients.Topological methods in Moduli Theory: strong, weak and pseudo rigidity for the Inoue type varieties of Bauer and Catanese (free quotients of ample divisors on projective varieties  which are K(\pi, 1)). With Lonne and Wajnryb, using methods by Auroux and Katzarkov: study canonical symplectic structures and  deformation types of some simply connected algebraic surfaces, determining  braid group factorizations associated to subcanonical projections. More general bicoloured braid factorizations associated to general projections. Teichmueller space of certain algebraic surfaces.Classification and Moduli of surfaces with low invariants. Surfaces of geometric genus 0: new construction techniques, structure of fundamental groups, moduli spaces, existence questions for surfaces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Drug Design for Cardiovascular Diseases: Integration of in Silico and in Vitro Analysis' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Recent technological advances have greatly increased the capability to investigate complex molecular interactions that occur in the onset of disease in order to identify genetic alterations and to screen new drugs.The first critical step of the drug deve lopment process is the identification and the validation of drug targets for the therapeutic application. At present about 500 molecular targets have been identified and validated.This is the basis of putative drug molecules that are able to interact wit h such targets.Recent advances have greatly speeded up the screening of the new drugs, however the number of resulting molecules which are not pharmacologically active is still extremely large. The optimisation of screening depends on the integration of in silico and in vitro analyses. The screening of targets is extreme difficult for multifactorial diseases, which are characterized by complex synergies between genetic and environmental factors.Cardiovascular diseases (CAD) are one of the major group of multifactorial diseases and are one the main causes of mortality and morbidity in most developed countries. The aim of this project is to discover new factors involved in atherogenesis and their related CAD and set up systems to select and test molecules that are pharmacologically active for the treatment of CAD.The project combines the computational (bioinformatics,cheminformatics and bioengineering) and the experimental (clinical medicine and biology) expertise.Clinical information drives bioinformati cs analysis.The results are the basic knowledge for cheminformatic analysis. Subsequently putative targets will be synthetised by industrial partner and tested on specific experimental models. These information,combined with physiological parameters, are used for the deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unlocking mushroom protein functionality and improving circularity by valorising the fibre side stream.' (MUSH4FUN).

assistant: **Innovation**

There is a current need to explore diverse alternative protein sources with improved technological functionality and digestibility. Mushrooms are a relatively low-cost and environmentally sustainable horticultural product, which are valued for their taste, fibre and protein content and several other health benefits. Surprisingly, few mushroom derived ingredients are commercially available e.g., mushroom powders. Their relatively high protein and fibre content have largely been overlooked, leaving an opportunity to explore these nutrients to generate mushroom based value-added ingredients. MUSH4FUN aims to go beyond the state-of-the-art by extracting mushroom protein and optimising the protein's  technological and digestive functionality while creating circularity through valorisation of the side-stream generated during protein extraction.This research work is comprised of four parts and will adopt multidisciplinary approaches. (1) Protein concentrates/isolates will be extracted from three mushroom varieties, i.e., white button, oyster and shiitake. Fibre will be isolated and purified from the residue. The technological functionality of the obtained proteins will be determined (WP1). (2) The in vitro protein digestibility of the protein concentrates in model emulsions and gel systems will be evaluated (WP2). (3) Innovative food products will be developed using protein and fibre obtained, as proof-of-concept (WP3). (4) The textural properties of the developed products will be evaluated instrumentally and through sensory evaluation by a consumer panel (WP5). This project addresses European Union's FOOD 2030 policy pathway 4 aimed at increasing the diversification of alternative protein sources and encouraging a dietary shift towards plant-based diets. Knowledge and concept