RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Engineering B cells against HIV using Switch targeting' under Horizon 2020.

assistant: **Concept**

Chronic antiretroviral therapy (ART) does not eradicate HIV infection. As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) were shown capable of secreting high and neutralizing antibody titers. In particular, we previously demonstrated that, upon immunization of mice, adoptively transferred B cells, that were engineered at the immunoglobulin heavy (IgH) locus by CRISPR/Cas9, differentiate into memory and plasma cells while undergoing class switch recombination (CSR) and somatic hyper mutation (SHM) followed by selection. B cells may thus be engineered as a living and evolving drug. In the current application we plan to greatly enhance the safety, efficacy and the scalability of our approach by engineering the B cells without CRISPR/Cas9.  CRISPR/Cas9 cleavage is associated with both on-target and off-target mutagenesis as well as with gross chromosomal aberrations.  Importantly, the activation of B cells is associated also with double strand breaks initiated by activation-induced-cytidine-deaminase (AID). Therefore, applying CRISPR/Cas9 to activated B cells may bear a combined risk for potentially oncogenic translocations. To avoid these risks, we reasoned that bNAb genes could be targeted to AID induced breaks at the IgH locus using adeno associated viral vectors (AAV) without CRISPR/Cas9. Here, we present preliminary supporting results and outline the research plan for establishing AID-induced B cell engineering (“Switch targeting”) as a single-shot functional cure of HIV. Switch Targeting includes unique safety features. It addresses viral variability between patients and counteracts viral escape. We have a previous track record in spinning out gene therapy start-up companies to build
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'The role of viruses on bacterial production in polar habitats'.

assistant: **Concept**

The main objective of the present research project is to determine the effects of increasing amounts of DOC and nutrients, as a result of increase in the glacial melts and consequent expansion in catchments area in high latitude lakes, on the interactions between viruses and bacteria.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unravelling the Astrocytic Code: Investigating the Role of Astrocytes in Information Processing' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

A major challenge in neuroscience is uncovering the mechanisms that give rise to the brain's cognitive abilities. Cognitive functions create internal representations (meaningful signals about their external environment or internal state) and perform computations on them to drive behaviours and physiological changes. Research on cognitive functions has primarily focused on neurons. Astrocytes, once seen as passive support cells, now are known to respond to and influence neuronal activity and behaviour. They have been shown to regulate circuits responsible for cognitive functions, however, it remains unclear whether they are integral elements of, or external modulators to, cognitive circuits responsible for information storage and processing. I will leverage my multidisciplinary training and recent advances to unravel the role of astrocytes in cognitive functions and determine whether astrocytes generate distinct representations carrying specific information used in circuit computations to guide behaviour.In AstroCode, I will image astrocytic activity using state-of-the-art two-photon mini-microscopes in freely moving mice performing a behavioural task involving stimuli of opposite valence to determine the specificity of the information encoded in astrocyte activity. Then, I will explore the functional specificity of astrocytic control over neuronal activity, studying the astrocytic involvement in the generation of distinct neuronal representations and in the selection of different adaptive behaviours. Moreover, I will use an innovative strategy to determine the functional role of naturally occurring astrocyte calcium signals in cognitive functions: a closed-loop stimulus-state strategy, in which sensory stimuli are delivered based on the presence of specific patterns of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Monitoring and control system for wastewater irrigated energy plantations' in the context of a Sixth Framework call.

assistant: **Objectives**

A main objective of the European Commissions energy policy is to raise the amount of renewable energies from currently about 6% up to 12% from total energy generation until 2010. Therefore a huge potential is seen in the application of biomass, which is competitive, storable, CO2-neutral and in connection with wastewater an extreme low-cost fuel for heat and power generation.The current main biomass sources like forest-wood, recycle-wood and biogas can not meet the future demand for heat and power generation in Europe. Therefore, it is necessary to develop high efficient and low-cost biomass production systems. Wastewater irrigated Short Rotation Plantations (SRP) can contribute to meet these requirements because they use the advantages of communal wastewater as a source for cheap fertilisation and irrigation for the cultivation of fast growing combustible energy crops(e.g. willows, poplars).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Impacts of PermaFROST degradation on peatLAND biogeochemistry' (FROSTLAND).

assistant: **Concept**

The degradation of permafrost has accelerated in subarctic and arctic regions. The southern boundary of permafrost distributionhas receded northwards over the last decades, and the degradation has also increased in the arctic zone ofcontinuous permafrost. This process is expected to persist in the future due to climate warming, which is amplified in circumpolar regions. Almost half of the world’s soil organic C is stored in permafrost, largely in permanently frozen peat. The degradation of permafrost in peatlands is particularly threatening because it may turn peatlands from C sinks to C sources and accelerate climate change. However, the coupling between C and nutrient cycles is still poorly understood, and needs to be addressed to properly understand the impacts of permafrost thawing on the functioning of peatland ecosystems and their feedback on global climate. FROSTLAND addresses some of these uncertainties. The overall aims are to elucidate the fine-scale biogeochemical changes occurring in the active layer and in deep permafrost across gradients of permafrost thaw in subarctic and arctic peatlands and to improve fine- and broader-scale estimates of nutrient availability and of C and nutrient stocks in different global warming scenarios. FROSTLAND is based on a detailed research plan that has been accurately designed to address these knowledge gaps. The achievement of these objectives will require the acquisition of new knowledge and skills by the researcher, who will be trained at PLECO (UAntwerp) under the supervision of Prof. Janssens, an expert in soil biogeochemistry. A secondment to the Dept. Physical Geography (Stockholm Univ.) will be supervised by Prof. Hugelius, an expert in modelling and upscaling of C and nutrients in permafrost and peatlands. The work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Wind Energy Generator Onshore and Offshore Inspector' (WEGOOI), addressing dissemination and exploitation.

assistant: **Impact**

Alerion Technologies commercialises turnkey data solutions for extreme environments through proprietary RPAS that are autonomous and intelligent. After a Feasibility Study, Alerion has decided to focus on windmill inspection market, due to its high barrier of entry, and geographical proximity to important customers that can accelerate international growth. According to the EWEA windmill operations and maintenance represents 30% of the cost of windpark project, and NREL (U.S. Department of Energy) estimates cost of windmill inspections €22K/ MW for onshore and €67K/ MW offshore. Nowadays, most windmill inspection tasks are performed using high-rise equipment and specially trained altitude workers. These solutions are expensive, time consuming, and inefficient for most cases, while effective autonomous and automatic damage identification tool such as an RPAS is a highly desirable solution across the industry. Alerion has estimated that the potential market for autonomous windmill inspection with RPAS is currently €830M annually, with expected growth to €2.6B by 2025. The WEGOOI systems developed by Alerion Technologies will allow customers to drastically reduce windmill infrastructure inspection costs, increase damage assessment effectiveness, and eliminate health risks. This platform is especially suited for structures of difficult access such as windmills, and the company will adapt its technology to fit the exact needs of this market.Alerion has been testing its technological developments in windparks maintained by a multinational company and service provider, and it has already validated Alerion’s prototype RPAS, for its windmill inspections. The prototype version of WEGOOI is at TRL6, capable of inspecting one blade at a time and analysing images in a ground computer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Delivery of elicitors and pathogenicity factors from bacterial pathogens and their interaction with plant cells: application of basic studies' (1994-1998).

assistant: **Concept**

This project brings together the most active groups working on bacterial pathogenesis within the EU. The common interest of the partners in this project is to examine the delivery of elicitors and pathogenicity factors and their interaction with plant cells. The bacterial pathogens to be studied, Xanthomonas campestris pv. vesicatoria (Xcv), Pseudomonas syringae pv. phaseolicola (Psph) and Ralstonia (pseudomonas) solanacearum (Rsol), cause economically important diseases. Rsol is a vascular pathogen with a remarkably wide host range and provides an important comparison with Xcv and Psph which primarily invade the intercellular spaces in leaf parenchyma. The proposal is based on seven interactive work packages on the following topics: 1. Molecular dissection of hrp gene structure and function. 2. Determination of the function of avirulence (avr) genes from Xcv and Psph. 3. Analysis of the bacterial surface structures involved in signal delivery to plant cells. 4. Identification of proteins (pathogenicity factors)secreted by the hrp dependent type III pathway. 5. Characterization of plant receptors for bacterial pathogenicity factors and elicitors of the hypersensitive reaction. Industrial partners will integrate with the basic studies to examine: 6. The effect of hrp genes on xanthan production. 7. Rational selection of chemicals for crop protection and antimicrobial activity. The objectives implicit in these work packages exactly match the research tasks specified in the work programme for Plant Molecular and Cellular Biology 3.1.3. Resistance to stress and pathogens namely: - Isolation of bacterial genes coding for pathogenesis factors and elicitor synthesizing enzymes. - Studies to reveal the nature of transduction pathways leading to disease resistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Underneath the attack: cortical network function in migraine' (2007-2013).

assistant: **Concept**

Migraine is a disabling brain disorder with major consequences to patients and society. Diverse genetic and physiological factors predispose for attacks, stressing the need for a multidisciplinary approach. In the host team at the LUMC, the Netherlands, migraine research led to identification of the first migraine genes and generation of transgenic mice harboring mutations that cause hemiplegic migraine in patients. An important focus of research at the host is on cortical spreading depression (CSD), the correlate of a migraine aura capable of triggering pain. The migraine mouse models of the host revealed increased neurotransmission resulting in enhanced susceptibility to CSD and other migraine-relevant phenotypes. Underlying mechanisms are not well understood, in regarding neuronal network function in migraine. A Marie Curie CIG will provide excellent support to use my expertise with monitoring neuronal network function and brain pH in these migraine mice in the multidisciplinary research setting of the host. The central question to my research is how sudden changes in brain physiology culminate in a migraine attack. My specific objectives are to (i) gain insight in changes in cortical network activity underlying CSD in freely moving migraine mice and study the role of external influences such as stress and sleep (ii) identify changes in sensory processing that make migraine mice susceptible to CSD, and (iii) investigate whether increased susceptibility to CSD in migraine mouse mutants relates to metabolic disturbances at the network and cellular level. My research will provide insight on changes in cortical function and sensory processing preceding and following CSD events in migraine mice which will help understand how pain mechanisms are activated in migraine. Such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Organizational Consequences Of E-mail Introduction, Adoption And Diffusion' (COMMORG), addressing dissemination and exploitation.

assistant: **Impact**

This project is aimed to investigate the socio-economic challenges, implications and opportunities associated with the introduction and diffusion of e-mail communication within the European Union. It will explain the new ways to communicate and co-operate overcoming geographical constraints. It will highlight the impact of new tools to support decision-making, to improve work conditions (teleworking, groupware), to sustain international co-operation through networking technologies and to reinforce cultural integration by adopting distance learning technologies in training and education. Moving from a theoretical framework, this project will focus on empirical research based on close interaction with business world and field studies. The project will develop a cross-national analysis among four European countries.Objectives:1. the way in which some explaining variables constraint the introduction, adoption and diffusion of e-mail communication within and between organisations, and the degree to which Computer Mediated Communication replace Face-to-Face communication;2. how e-mail adoption/diffusion influences the formation of trust and identity within and between organisations;3. how e-mail adoption/diffusion influences the structure and evolution of power, decision-making and participation within organisations;4. which types of adoption and practical use are generated by any single organization;5. what patterns of adoption/diffusion emerge when considering e-mail communication as a type of technology.Work description:The research project is aimed to analyse the impact of the introduction, adoption and diffusion of E-mail communication on the evolution and change of organisations' structure and processes. The explaining variables identified are:1) task complexity;2) self
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chemical bonding and aromaticity in novel inorganic and organometallic clusters' (CANIOC) targeting Seventh Framework.

assistant: **Abstract**

Clusters behave as a link between the atom and the bulk material. They exhibit characteristics of both forms of matter, depending on their size and their molecular and electronic structures. Such molecules can be potentially useful for technical applications as specific and very efficient catalysts, drugs, and other novel materials with as yet unimagined properties. As an example, the continued miniaturization of electronic devices is pushing towards the nano- and molecular scales. In this sense, silicon clusters can be very important in the future development of the electronic industry. Other clusters are expected to have relevant catalytic or magnetic properties. All-metal and semi-metal clusters have been recently discovered. The unusual stability of all these clusters comes from their aromatic character. Indeed, the aromaticity is a key property of these compounds since it explains their stability and reactivity. As compared to the classical aromatic organic molecules, that possess only π-electron delocalization, the aromaticity in inorganic clusters is more complex. These compounds have σ- and π- (or even δ-) electron delocalization, thus giving rise to the so-called multifold aromaticity. All-metal and semimetal aromatic clusters represent one of the “new frontiers” of chemistry (the first of such clusters was discovered in 2001). It is expected that understanding the origin of aromaticity in these systems will help us to comprehend the factors that govern structural patterns and stability in solids. In addition, these novel materials are expected to have as-yet unimagined properties such as, for instance, nanodevices, intense non linear optical properties, high catalytic power and efficiency, and utility as possible drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Who Needs Virtue? The Early Academy and the Way to Happiness'.

assistant: **Objectives**

‘Who Needs Virtue? The Early Academy and the way to happiness’ (WNV) aims to show that the theories developed in the Early Academy - the phase of the Academy immediately following the death of Plato - are crucial for understanding the dynamics and interplay of the origin of the debate on virtue and happiness in the 4th century BCE.How do we human beings attain happiness? And to what extent, if any, does virtue contribute to happiness? These questions lie at the heart of Western ethics from as early as the 5th century BCE. In antiquity, there were two major, competing answers to the question of how happiness and virtue are related. The first model, advanced by Plato, suggests that virtue (arete) is a sufficient condition for human beings to secure happiness (eudaimonia). Differently, Aristotle holds that virtue is not sufficient for someone to live a happy life, for other (non-moral) goods (e.g., health, wealth and friends) are also required. These two models are usually examined in terms of their similarities and differences. Yet, what is missing from the picture is an account of the framework in which this debate originally emerged and the discussions that contributed to shaping these responses. WNV seeks to fill this gap by advancing the hypothesis that coeval developments in ancient virtue ethics can be more effectively understood as the result of a dialectic with and in the backdrop of the discussions of virtue and happiness conducted by the first generation of Plato’s students.


**Keywords:** History of Platonism,  Classical philosophy,  Early Academy,  ancient ethics