RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Mechanistic basis of isoniazid activation in tuberculosis treatment : A molecular model for developing lead compounds to combat drug resistance'.

assistant: **Innovation**

To characterise the enzymatic activities of the catalase-peroxidase from Mycobacterium tuberculosis and related variants . To characterise the molecular mechanism and putative intermediates associated with isoniazid activation . To determine the structure of the active site of catalase-peroxidase using NMR and/or x-ray crystallographic methods . To prepare synthetic lead compounds targeted for drug-resistant strainsTo develop a new line of therapeutics aimed at providing an alternative treatment regime for multi-drug resistant strains of Mycobacterium tuberculosis, we take advantage of the participants' expertise in biochemistry, organic synthesis, NMR and crystallography. A functional description of the active site or sites of the recombinant katG gene product, catalase-peroxidase, will be established using a variety of techniques including visible spectrophotometry, electron paramagnetic resonance and nuclear magnetic resonance spectroscopy. Hypothetical mechanisms for the activation of the anti-tuberculosis drug by this enzyme will be tested using synthesised intermediates," in both biological and model chemical (enzyme-free) systems. Classical analytical chemistry methods including NMR, HPLC, mass spectrometry and stopped-flow kinetics will be integrated with genetic engineering and other biologically based-studies to observe and characterise critical intermediates in the reaction pathway. Parallel efforts to obtain additional information about active site structure and ligand interactions will be carried out using paramagnetic NMR and x-ray crystallographic methods. Comparison of the functional and structural data will contribute insight into the metabolic activation mechanism of isoniazid, suggesting new lead compounds for alternative treatment regimes."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Standardization of Ice Forces on Offshore Structures Design' (STANDICE) under Sixth Framework.

assistant: **Objectives**

During the past six years two RTD-projects have been performed by a consortium of seven European partners to investigate ice forces on marine structures. The aim of this work has been to establish new methods for ice load predictions. The work has been supported by the EC under the projects LOLEIF and STRICE. The data compiled by these projects are of great importance for the future development of offshore wind energy converters, OWECS, in the ice-covered seas of Europe. Because the ice forces on marine structures are internationally heavily disputed the present design codes for OWECS as well as for all marine structures in ice-infested waters are not been considered reliable. Therefore, the main objective of this project is to contribute to the development of an international standard for the design of marine structures such as OWECS against ice loads with special emphasis on European sub-arctic ice conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Control mechanisms and robustness of multicellular symmetry breaking' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Understanding the establishment of an animal body plan is an important challenge of modern biology. Progress has been mainly limited by (1) a separation of research fields studying genetic and biophysical mechanisms, and (2) a lack of approaches to mimic multicellular tissue organization from first principles. In a cross- disciplinary effort, we will focus on the earliest stages of animal development, when first steps of cell differentiation define the primary body axis through spatial symmetry breaking, laying the foundation for the future body plan. Our goal is to identify the fundamental mechanisms controlling this symmetry breaking process. To this end, we will study in detail the interplay between global tissue geometry (shape, size, and dimension), physical boundary conditions, and mechano-chemical cell interactions. Therefore, we address the following questions: (i) How do global shape and size control local cellular states and interactions? (ii) How do local cellular states and interactions induce robust symmetry breaking at the tissue level? (iii) To which extent can geometry control cell fate specification in a species-independent manner? To overcome previous limitations, we will establish a comprehensive methodological toolbox of synthetic bottom-up approaches and functional ex-vivo assays. We use as model systems mouse, zebrafish, and later also human embryonic stem cells. This will be combined with advanced biophysical techniques and theoretical modeling in order to systematically dissect the mutual couplings between genetic patterning mechanisms and morphogenetic processes, thereby revealing the multicellular dance underlying tissue symmetry breaking. Our results will shed new light on the long-standing question of how complex biological forms are robustly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multiplex detection of quarantine plant pathogens from soil by microarrays combined with amplification technology' (1998-2002) under Fifth Framework.

assistant: **Objectives**

We aim to develop a prototype multiplex assay, by combining target-specific legation (padlock probes), nucleic acid amplification and micro arrays, for the detection of several soil- borne pathogens. Further, we plan to advance the technology by developing a software tool for aiding assay design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Collaborative Engagement on Societal Issues' (COESO), addressing dissemination and exploitation.

assistant: **Impact**

The COESO (Collaborative Engagement on Societal Issues) project facilitates and supports participatory research in SSH, through a service-first approach. COESO supports ten Citizen Science pilots presenting a variety of disciplines, societal challenges and types of engagement with citizens in different European countries. COESO project will specifically support collaborative practices in Citizen Science by developing a Virtual Ecosystem for Research Activation (VERA), a platform envisioned as a ""collaboratory” providing a set of tools to discover potential partners, to define and co-design the activities, to co-create new knowledge and solutions, and to deliver them to society.COESO will furthermore collaborate with research funding organizations to enhance financial support to Citizen Science projects in the SSH and explore the frontiers of innovation in SSH public engagement by achieving a complete mutual learning with the teams involved in the Pilots. Finally, “Cooperation analytics” will be designed to measure the quality of collaboration between researchers and citizens in VERA. Those analytics will be useful to the project teams themselves but they will also be a major contribution to funders, policy makers, research organizations and other stakeholders supporting Citizen Science policies.COESO’s overall objective is to overcome the obstacles that hinder the development of Citizen Science in the SSH. COESO will enable a dramatic growth of Citizen Science projects in these disciplines and will intensify the collaborations between SSH researchers and citizens to tackle together the many societal challenges European societies face today. VERA will be one of the core services offered by OPERAS Research Infrastructure to the scientific community.""


**Keywords:** Cit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Model enhanced solution methods for integer programming software' (MEMIPS) under Fourth Framework.

assistant: **Objectives**

Many industrial decision processes, production planning problems, distribution problems, and problems occurring in logistics can be described as mixed-integer linear optimisation problems. However, the ability to solve these industrial problems depends on the sophistication of the tools and techniques available. This project will remedy the inadequacies of the tools currently available by developing a flexible, general-purpose commercial software tool for this class of problems. This will provide industrial modellers with access to new, more powerful methods capable of solving problems currently considered intractable. High-performance parallel computers offer the means to obtain solutions to difficult problems within an industrially relevant timeframe. These tools will be developed on parallel high-performance hardware available at all the partners and will be used to solve critical industrial problems at BASF, Unilever, PowerGen and Tractebel. The primary output of the project will be a set of tools which embody expert knowledge and adhere to best practice. The primary results will be much faster solution times for difficult and wider-ranging problems. This in turn will bring greater operating efficiency, reduced costs, better knowledge and understanding of industrial processes, and improved competitiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Building a Protein Sequence Library using Nanopores' in the context of a Horizon Europe call.

assistant: **Objectives**

Nanopore is a breakthrough genomic sequencing tool with long read length, high accuracy, and high throughput in reading DNA. However, it is the proteome that ultimately determines the cells phenotype, and tremendous efforts have been made to develop sequencing techniques for reading proteins in the past decade. First breakthroughs have been appearing for sequencing short peptides at the single-molecule level. Current strategies are however still far from sequencing full-length native proteins due to the low synthesis efficiencies in protein handling and the limited scanning length (can only read short peptides with ~25 amino acids). Here, I will first develop a novel method to synthesize a large variety of proteins that are connected to DNA with their own codon sequences, using just a few reactions with a puromycin linker labeled to a mRNA, and followed by in vitro translation, reverse transcription, and RNase cleavage. Furthermore, I propose a single-molecule protein nanopore engineering strategy that significantly extends the MspA nanopore lumen length to push the limit for protein reading length. With the proven abilities of a Hel308 DNA helicase, the engineered nanopore can read the entire DNA codons first, followed by the read of >100 amino acids of the protein. Upon recording large data sets, I will build a protein signal library with the related codon information for the training of a machine learning model, which serves as a tool for de novo protein sequencing. This work has great potential to push the limits of sequencing technology to reading the whole proteome.


**Keywords:** Nanopore, Protein sequencing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Combined Scene and Object Recognition' under Sixth Framework.

assistant: **Concept**

Humans have the impressive ability to recognize even noisy or blurred objects in scenes by using global context information. For instance, we expect the grayish blob in the image to be a car rather than a wild animal when the image has been taken in the streets of a metropolitan area. The importance of context information for humans has also been proven through psychophysical experiments. Due to its applicability for content-based image or video retrieval, research in computational image understanding, i.e. the automatic description of scene class, objects in the scene, and object and scene interrelations, has recently gained increased attention. Up to now, these different recognition tasks have mainly been treated separately.However, the findings from psychophysics suggest that the combination of scene and object recognition will be also beneficial for computational scene description. The goal of this research project is to develop a computer vision system for combined scene classification and object categorization. The idea is to combine bottom-up knowledge, e.g. from low-level features, with top-down knowledge, e.g. information about the scene class, in an iterative manner. The hypothesis is that object classification accuracies will improve due to the use of scene context, even if the information from low-level features is of low quality.The combination can be achieved best using statistical methods. Statistical models have been shown to be well suited for both scene and object recognition approaches. The project aims for improving upon state of the art by a statistical approach for combined scene and object recognition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Doctoral training network TAu imMunE: strategies for innovative diagnosis and therapies in dementia' (TAME), addressing dissemination and exploitation.

assistant: **Impact**

There is an urgent medical need for efficient diagnostics for Alzheimer’s disease and related tauopathies, as well as disease modifying treatments, due to the heavy burden of the disease on patients, families and society. To address this public health issue, TAME R&I training network gathers leading academic and industrial experts in tau research with the ambition to keep older people active and independent for longer. TAME aims to provide better understanding of tau-related diseases and supports the development of new, safer, personalised and more effective diagnosis and interventions for AD and the less common tauopathies. The beneficiaries and partners bring together resources and knowledge across different fields and technologies to provide a multidisciplinary approach necessary to take on the challenge. They have teamed-up to combine molecular and cellular neuroscience with computing, chemical and bio-engineering and their technology expertise. The first tau network of Europe, TAME, will focus on novel approaches using nanobodies, which have emerged as very promising antibody formats in tau research. The primary objective of the TAME is to train 9 fellows to deliver the next generation of talented life scientists. The program will be a combination of training in research, in personal and professional development and in open science, achieved by conducting research projects, attending courses and benefiting from internal mobility within TAME. The research training is based on cutting-edge technologies and advanced models for medical research, emphasizing the need for more human-based research, gender-personalised models and reduction in the use of animals. Consequently, through intense collaboration with all partners and the relevant industrial experience, these 9 f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Biorefinery combining HTL and FT to convert wet and solid organic, industrial wastes into 2nd generation biofuels with highest efficiency'.

assistant: **Innovation**

Heat-to-Fuel will deliver the next generation of biofuel production technologies towards the de-carbonisation of the transportation sector. Heat-to-fuel will achieve competitive prices for biofuel technologies (<1€/l) while delivering higher fuel qualities and significantly reduced life-cycle GHG reductions. Heat-to-fuel will result in increased Energy production savings (>20%) and enhanced EU’s energy security by the use of local feedstocks which in turn ensured local jobs are preserved and increased. The benefit of combining technologies like in Heat-to-Fuel is, that the drawbacks of the single technologies are balanced. FT and APR are promising technologies for the efficient production of 2nd generation fuels. But currently the economic border conditions don't allow the implementation, similar to many other biofuel technologies. The radical innovation of combining an APR with a FT reactor is the basis to overcome this barrier. The large organic wastes (from HTL or other streams) can be conveniently treated with APR to produce H2. Both dry and wet organic wastes can be integrated, with mutual advantages, i.e. steam production for gasification, HTL and APR preheating; FT heat cooling without external utilities. Using the synergies between these technologies maximizes the total process efficiency. Heat-to-fuel aims will be met thanks to the diversification of the feedstock for biofuels production, reducing the supply costs and upgrading the efficiencies of promising and flexible conversion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Predisposed mechanisms for social orienting: A comparative neuro-cognitive approach'.

assistant: **Concept**

Predispositions for newly hatched/born vertebrates, including humans, to attend to and preferentially learn about conspecifics, are pervasive and can be of vital biological importance. Such predispositions are, however, very poorly understood. Studying them, and their physiological, genetic, molecular and neural bases, is crucial for an understanding of typical and atypical human development. Indeed, some have suggested that lack of such predispositions may contribute to autism. We will develop a detailed animal model of vertebrate social predispositions using the domestic chick, relating this work closely to equivalent behavioural and neural measures in human newborns including those at risk of autism, for which there is no widely accepted animal model. We aim to:(1) identify in chicks neural systems underlying known social predispositions; (2) study their physiological, genetic and molecular bases; (3) pursue behavioural parallels between chick and human predispositions; (4) study brain structures activated in human newborns as they view social stimuli; (5) by studying social attachment in chicks not expressing specific predispositions, develop a secure animal model of autism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transforming Our World: Collections at the Heart of life-long learning and Education' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

TOWCHED will demonstrate transformative potential of inclusive, arts-based and heritage collections-mediated educational interventions for children and youth, using SDGs as the results framework. These interventions, piloted in collaboration between Creative and Cultural Industries (CCIs), Collections-based Organizations (CBOs) and educational institutions across Europe, will be critically assessed,providing a field-tested and well-supported roadmap to enriching our learning ecology with creative use of heritage, thus making Europe, and our world, a better place for all. Our innovative approach relies on the application of the Human Rights-based Approach (HRBA) as a project planning tool, which is foundational in Agenda2030 and the SDGs. TOWCHED will actively engage with children, young people, educators, creatives, heritage professionals, policymakers and professional development providers to ensure our goals and impacts are not only achieved, but that stakeholders can shape these goals in line with the principles of Leave No-one Behind, and the Right to Development. Furthermore, we will focus on lifelong perspectives, from early childhood education and care to young adult education in formal and non-formal learning environments. We will seek to empower CBOs to be more effective in supporting sustainable development through educational activities that foster people’s active, free, and meaningful participation. Our transdisciplinary approach will lead to creation of community of practice for competence-based sustainable development education and life-long learning rooted in our rich European heritage. The project will provide practical tools, and develop capacities to use these tools. In pursuit of these objectives, we will work closely with the transdisciplinary New Eu