RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Single-molecule analysis of RNA conformational dynamics in Human Immunodeficiency Virus 1(HIV-1)' (HIV-1) under Sixth Framework.

assistant: **Objectives**

Conformational changes in bio-molecules are closely linked to their function and thus of major interest for an understanding of many biological processes. For a number of biologically active RNA molecules there are indications from biochemical assays that they are able to regulate their function by switching between different conformations of similar energetic stability. An important example is the RNA genome of the Human Immunodeficiency Virus (HIV), which is responsible for the AIDS disease, one of the mo st serious pandemics ever caused by a virus. Despite an intensive research effort the ultimate vaccine or drug against this disease has not yet been successfully developed. The difficulty related to this can be explained by the extraordinary high rate of g enetic evolution of the RNA genome, which is related to a high mutation rate and a tendency of the RNA molecules to form dimers. The mechanism by which dimerization is initiated and regulated in the viral life cycle is not very well understood but is belie ved to be mediated by conformational changes in the RNA. The objective of the present project is to address in detail this issue with a new experimental technique, single-molecule fluorescence-resonance-energy-transfer (FRET) microscopy, which promises im portant new knowledge that cannot be obtained with traditional, ensemble-averaging methods. The activity proposed here is very much in line with the objectives of the Marie Curie Actions, implying the transfer of knowledge and promotion of European scienti fic excellence, and depending on interdisciplinary collaborations at the national and European levels. Furthermore, it can be classified as nanoscience as well as life science and biotechnology, all of which are declared priority levels of the European Com mis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Trophic role of benthic cnidarians in energy transfer processes in marine polar subliminal ecosystems 6'.

assistant: **Objectives**

Research objectives and content In recent years the paramount role of benthic suspension feeders in energy transfer processes in littoral ecosystems has become evident. A previous study pointed out the importance of several cnidarian species in the transfer of energy from the planktonic to the benthic system. In addition, there is some evidence that besides the zooplankton the finer fraction of suspended organic matter (bacteria, organic particles, phytoplankton) may represent a more important contribution to diets than previously assumed. The project will focus on adaptations of polar benthic cnidaria to the seasonal cycle of food availability. The availability of food resources, including potential alternatives like resuspended benthic material, which was not yet taken into account, will be investigated. Particular interest lie in the question, whether polar benthic cnidaria adapted to another type of diet than that reported for these organisms in temperate regions, thus enabling them to exploit such alternative food resources available in polar waters. Training content (objective, benefit and expected impact) The applicant already accumulated data from earlier work in the Mediterranean, the North Atlantic and the Antarctic, to which the expected Arctic data would provide an important complement. The biochemical, especially enzymatic, as well as electron microscope methods included in this project are new to the applicant and will be useful for application to preserved material from the other areas of interest (in fact, training on the electron microscope is already begun). Moreover, the applicant's interest lie in a field of ecology, which need complex and well organized studies. The necessary know-how to perform this type of study can be acquired working under the g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'StoreHero: An AI (Artificial Intelligence) Virtual Business Coach for Physical Retailers' under Horizon 2020.

assistant: **Concept**

90% of total retail sales are still generated by offline retailers, yet but most physical retailers find it hard to make sense of all the data that is available to them and use that intelligence to drive their decision making and compete with online. They are sinking in data from POS systems, intranets, and internal processes, and aren’t equipped to absorb complex analytics. In order to solve these problems, Measurence has developed and will launch StoreHero.StoreHero is an AI-based virtual business coach for physical retailers. It helps store owners and operators grow their business. Thanks to data collected through a variety of sources, it sends text-messages and notifications with insights and recommendations on how to improve the retail business, based on the intelligence generated by our proprietary platform of interconnected and remotely-managed plug-and-play sensors. It helps shop owners, for example, to run more effective promotions by informing ahead of time when and how it's the best time to advertise to capture most customers. It can help to optimize store opening hours by monitoring events outside of a store. StoreHero serves as a business guru for our clients, allowing simple interaction and providing insights after analysing hundreds of gigabyte of raw data very quickly, simply and effectively. From store managers to executives, everyone will have access to information in an immediate format, with the ability to easily share it and make cross-store comparisons. During this project, we will enhance our IoT platform as well as our machine learning software. We will estimate the growth potential of clients for next 5 years. We will also analyse the customer requirement, IPR protection strategy, competing technology and promotional activity in this study. All
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'INTEGRATING SUSTAINABLE MOBILITY AND LOGISTICS WITH CITIZEN-CENTRIC INTELLIGENT SOLUTIONS FOR SAFE, SMART, GREEN, RESILIENT, AND INCLUSIVE CITIES'.

assistant: **Objectives**

BIO-INTEL-MOB aims to revolutionize peri-urban mobility, logistics, and governance through AI-driven, citizen-centric, and climate-neutral solutions. Addressing fragmented mobility networks, inefficient logistics, and governance gaps, the project integrates Advanced Mobility Data Space (aMDS), Peri-Urban Mobility Hubs (PUMHs), Green-Safe Routing Algorithm (GSRA), bio-packaging logistics units (bioPLU), and Digital Twin ecosystems. By leveraging AI-powered risk detection, emission monitoring, real-time analytics, multimodal transport optimization, and VR/AR-enabled participatory governance, BIO-INTEL-MOB enhances urban-peri-urban accessibility and connectivity, reduces private car dependency by 35%, and optimizes multimodal transport efficiency by 35%. The project’s interventions will lead to a 30% reduction in urban-peri-urban congestion, a 25% decrease in logistics-related emissions and packaging waste. Further, BIO-INTEL-MOB will cut VRU-related accident risks by 35%, improve air quality and noise pollution by 20%, and reduce the human health impact of transport-related pollution by 30%.The project conducts large-scale pilot demonstrations in Rome, Cascais, Riga & Vilnius, alongside satellite pilots in Melsungen, Ciampino, Urla, and Rhodes, ensuring scalability and transferability. Through policy-aligned smart city governance (SCGo) with policy engine, citizen-voice-app and knowledge-hub, and AI-driven multimodal transport innovations, BIO-INTEL-MOB strengthens citizen participation in city planning by 40%, creating data-driven and participatory ecosystems. The project’s AI-driven models will ensure a 40% increase in participatory governance efficiency, 25% faster policy compliance processes, and a 35% improvement in co-designing of city policies and infrastructure. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Use of Graphics Rendering and Artificial Intelligence for Improved Mobile Search Capabilities' under Seventh Framework.

assistant: **Concept**

The principal aim of this project is to develop and apply revolutionary graphics rendering and artificial intelligence (AI) methods to an existing social media search engine platform (known as Tapastreet) thereby creating ground breaking mobile search capabilities with significant online commercial potential.Specifically these goals will be achieved by meeting the following Scientific & Technological Objectives – (a) the creation of dynamic graphics rendering algorithms (b) the development of powerful location based AI machine learning algorithms and (c) integration of both these technologies into a live geo-located social media search engine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Driver's desk advanced concept implementation - Contribution to Foster Interoperability' (EUDDPLUS).

assistant: **Concept**

EUDDplus aims at the development, in-field testing and validation of the interoperable, harmonised and modularised train driver's desk. It represents the logical and necessary link between the successful FP 5 project European Driver's Desk (EUDD) and the large-scale exploitation of that driver's desk concept, advanced in ergonomics, safety and LCC, being the important crystallisation point" for the MODTRAIN IP. Simultaneously, EUDDplus shall use the intermediate findings of this ongoing IP in which the EUCAB working area elaborates the harmonised driver's cab system requirements specs (SyRS) of the future. EUDDplus is designed as a multi system stepwise approach involving modular and integral phases. Due to its more ambitious complexity, the locomotive application has been chosen for first field testing under real operational conditions with a pre-competitive R&D approach. Using the EUCAB intermediate results, the locomotive version EUDDplus shall differ from the EUCAB multiple unit case is some details due to operational and vehicle platform constraints. It is the aim of the EUDDplus team to minimise the configuration and layout differences for different kinds of rolling stock. A modern multi system locomotive will be the platform for EUDDplus integration. Constraints given by the vehicle are to be respected, opportunities for efficient future desk upgrading will be considered as far as requirements have been identified and specified in detail. The project EUDDplus consists of the major steps: specification compliant to ORS/FRS/SyRS/FIS, development and vehicle integration of the new desk including software development, in-field tests in least two networks (including the necessary certification), involving drivers from several other operators to justify expected advant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Celiac disease: from lincRNAs to disease mechanism' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Celiac disease affects at least 1% of the world population. Its onset is triggered by gluten, a common dietary protein, however, its etiology is poorly understood. More than 80% of patients are not properly diagnosed and they therefore do not follow a gluten-free diet, thereby increasing their risk for disease-associated complications and early death. A better understanding of the disease biology would improve the diagnosis, prevention, and treatment of celiac disease.This project investigates the disease mechanisms in celiac disease by using predisposing genes and genetic variants as disease initiating factors. Specifically, it will investigate if long, intergenic non-coding RNAs (lincRNAs) are causally involved in celiac disease pathogenesis by regulating protein-coding genes and pathways associated with the disease.This project is based on two important observations by my group: (1) Our genetic studies, which led to identifying 39 celiac disease risk loci, suggest that the mechanism underlying the disease is largely governed by dysregulation of gene expression. (2) We uncovered a previously unrecognized role for lincRNAs that provides clues as to exactly how genetic variation causes disease, as this class of biologically important RNA molecules regulate gene expression.The research will be performed in CD4+ T cells, a severely affected cell type in disease pathology. I will first use celiac disease-associated protein-coding genes to delineate their regulatory pathways and then study the transcriptional programs of lincRNAs present in celiac disease loci. Next I will combine the information and investigate if the expressed lincRNAs modulate the pathways and affect T cell function, thereby discovering if lincRNAs are a missing link between non-coding genetic variation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Photochemistry at the Ocean's Surface: Effects and Interactions of Dissolved Organic Matter with Microplastics' under Horizon 2020.

assistant: **Concept**

Microplastics represent an increasing threat to aquatic ecosystems, with potential impacts on the cycling of fundamental elements and ecological consequences at all trophic levels. Low-density polyolefins, like polyethylene and polypropylene, are the most common plastics produced and are ubiquitous in marine environments. Floating on the sea-surface, they can have direct and indirect impacts on the sea-surface microlayer (SML), a key interface for biochemical and photochemical processes controlling gas exchange between the ocean and the atmosphere. The SML is an enriched biofilm of organic biological material aggregating and favouring high microbial activity. The effects of an increasing presence of microplastics on the cycling of organic matter in the surface ocean are not well understood, and yet they may have a major impact on this key interface. POSEIDOMM will investigate the influence of microplastics on the photochemical and biological processes in the SML. We will verify the effect of microplastic pollutants on the formation of a surface-active biofilm, the implications for microbial cycles and for the photochemical generation of reactive chemical species and labile organic compounds. The goals of POSEIDOMM are to provide a chemical and biological characterization of the microplastic-biofilm aggregates in the SML, to quantify the photochemical cycling of such aggregates and to identify the implications of this cycling on gas exchange and on the microbial carbon cycle.This will be achieved through a trans-disciplinary approach combining innovative spectroscopic and biological analyses to study the SML in controlled microcosms and in-situ mesocosm studies. Through a close cooperation with leading European partners, POSEIDOMM will close major gaps in our understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The brain erythropoietin cycle as driver of adaptive neuroplasticity via functional hypoxia'.

assistant: **Concept**

Cognitive disability and decline play key roles in neuropsychiatric conditions but lack effective therapies. Erythropoietin (EPO) is a hypoxia-inducible growth factor, named after its original description in erythropoiesis. We discovered - by 'reverse approach' (human trials first) - that recombinant human (rh) EPO has potent procognitive effects, hematopoiesis-independent. Searching for mechanistic insight in mice, we saw that rhEPO markedly drives differentiation/maturation of pyramidal neurons and oligodendrocytes from non-dividing precursors in cornu ammonis, outside known neurogenesis areas. In parallel, rhEPO dampens microglia. This suggests that endogenous, brain-expressed EPO (bEPO), acting in auto/paracrine fashion, has fundamental, hitherto overlooked physiological significance.BREPOCI will pursue the groundbreaking hypotheses that (I) 'functional hypoxia' is a physiological consequence of increased neuronal activity, inciting an integrated response of many brain cell types and (II) this activity-induced hypoxia stimulates bEPO expression to optimize multicellular brain plasticity, providing substantial 'hardware upgrade'. (III) Also, BREPOCI postulates diverse EPOR in brain and will study their nature and contribution to these pivotal processes upon normoxia, 'functional', and inspiratory hypoxia. (IV) rhEPO treatment of intellectual disability/autism caused by Tbr1 or Zbtb20 loss-of-function mutations will constitute a first mechanistic approach to specific brain pathologies, translatable to humans.This ERC project can build on acquired novel genetic mouse tools (cell-type specific EPO/EPOR mutants, inducible hypoxia reporters, multiomic mice), sophisticated behavior tests, MRI/MRS, multiphoton imaging, NanoSIMS, sc/snRNA-seq, confocal/Lightsheet/electron mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Thermally OPerated Mobile Air Conditioning Systems' (TOPMACS) under Sixth Framework.

assistant: **Objectives**

The goal of this project is to develop mobile air conditioning systems with a reduced impact on the environment, both direct and indirect.Two new technologies will be explored:Metal Hydride, either powered by waste heat or by electric energySorption Cooling, powered by waste heatNeither of these technologies uses HCFCs, and so they do not have a direct impact on GWP. The key point is to develop systems that will have also lower indirect impact with respect to state of the art of mobile air conditioning systems. Both technologies has the potential for pre-cooling and pre-warming of the vehicle cabin. In addition to that, the advantages arising from the integration of a near zero Auxiliary Power Unit (APU) based on a Rankine cycle and able to provide electric power and heat (that can be modulated independently) will be evaluated so to study innovative architecture for the energy management of the overall vehicle.Two applications will be considered: Passenger carsLight and heavy trucksThe objective is to set up at least two prototypes: a truck and a car. Benefits for the environment will be quantified by means of calculations and tests in a climatic chamber and on the road. A methodology to evaluate at the same time thermal comfort and the associated energy performance will be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Redox Materials-based Structured Reactors/Heat Exchangers for Thermo-Chemical Heat Storage Systems in Concentrated Solar Power Plants' under Seventh Framework.

assistant: **Concept**

ThermoChemical Storage (TCS) involves the exploitation of the heat effects of reversible chemical reactions for the “storage” of solar heat. Among gas-solid reactions proposed for such an approach the utilization of a pair of redox reactions involving multivalent solid oxides has several inherent advantages that make it attractive for large-scale deployment.The new concept introduced in the current proposal is instead of using packed or fluidized beds of the redox material as the heat storage medium, to employ monolithic structures like honeycombs or foams, made entirely or partially from the redox oxide materials. The proposal stems from and capitalizes on a number of ideas, concepts and achievements materialized in previous co-operations among the current consortium members:-The successful development, qualification and demonstration of honeycombs made of advanced ceramics to operate as effective volumetric solar thermal collectors/heat exchangers in Solar Thermal Power Plants.-The successful demonstration and scale-up to the 100-kW of “structured” honeycomb reactors involving coating of mixed-iron-oxides-based redox materials on advanced ceramic supports for cyclic solar hydrogen production.-The capability of several multivalent oxide-based redox systems to be used in thermochemical storage cycles in order to store and release heat in Concentrated Solar Power (CSP) plants.The proposed concept combines the demonstrated technologies of ceramic volumetric receivers and structured solar reactors and promotes them one step further to the development of an integrated receiver/reactor/heat exchanger configuration with enhanced heat storage characteristics, through a series of innovations to be implemented concerning new reactor/heat exchanger designs, enhanced incorporation