RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Home Energy RenOvation Service' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The 3 years long I-HEROS projects aims at developing a fully integrated home renovation service in Toulouse Métropole, the 4th French city with an urban area of 1.3 M inhabitants. The project aims at enhancing cooperation and coordination between existing programs and initiatives while adding innovative elements such as a technical diagnostic tool developed specifically for the Toulouse Métropole housing stock. This will be achieved through a strong consortium relying on partners with in-field experience in the technical, digital, social, legal and administrative aspects of renovation, as well as through a strong support and implication of the local actors. The consortium will capitalize on a widespread regional and national coverage to ensure efficient dissemination of the results and upscaling. The partnership with a German partner ZEBAU, with extensive experience in EU dissemination, will initiate cooperation and replication on an intricate level with the city of Hamburg and Germany. Long term sustainability of the service will be ensured through the development of an attractive financial offer and a robust business plan developed by the consortium under the lead of the Caisse des dépôts et Consignations. To reach the ambitious objective of renovating 2000 homes per year after the project, a 2-year trial period will initiate 500 renovations per year. During this trial, KPIs tracking and an external evaluation will enable the monitoring of the service performances and its optimization to ensure both the quality and sustainability of the service, ultimately improving homeowners trust. It is expected that, 3 years after the end of the project, 70 M€ of investments in renovation will have been triggered with more than 500 homes saved from energy poverty situations while
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Operational Radar For Every drill string Under the Street' (ORFEUS).

assistant: **Innovation**

Horizontal directional drilling (HDD) offers significant benefits for urban environments by minimising the disruption caused by street works. Use of the technique demands an accurate knowledge of underground utility assets and other obstructions in the drill path.This proposal is to progress the prototype HDD bore-head radar technology developed under the project ORFEUS  to a commercial stage.ORFEUS (“Optimised Radar to Find Every Utility in the Street”) was a 6th Framework collaborative research project. One of its aims was to design a prototype innovative ground probing radar (GPR) based real-time obstacle detection system to increase the safety margins of HDD to allow its use in the widest possible range of conditions. A successful outcome was a working, rigorously tested, prototype “bore-head GPR”.  Most of the objectives of ORFEUS were fulfilled, with results in crucial areas giving confidence to carry out further development to produce a commercial system.Unresolved technical issues requiring further work are associated with the optimum antenna configuration and electrical/mechanical interface to the disposable drill head; identification and validation of the most effective bore-head GPR data processing algorithms; validation of performance, and ruggedisation of the data communication link; validation of performance, and ruggedisation of the connector systems.Extensive testing and validation, as well as supporting the demonstration and exploitation of the final product, is proposed. The crucial testing and evaluation phase will assess the risks, confirm environmental benefits and increase end users’ (public authorities and industry) confidence, awareness and uptake of this new technology.Technology transfer, training and standardisation, in cooperation with Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ICone: a novel device to scale up robotic rehabilitation and unlock the potential of motor recovery for stroke survivors.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

ICone - The best therapy, everywhere.THE NEED FOR REHABILITATION IS INCREASING. Increasing the effectiveness of rehabilitation and lowering its cost is a global challenge, according to WHO. Due to the ageing population and higher survival rate after brain injuries (strokes), the number of stroke patients is increasing. Even years after the cerebrovascular accident, chronic patients hold potential for motor recovery; yet, intensive, interactive, challenging and personalized therapy is needed – this requires huge cost, long time, and resources.ROBOTIC REHABILITATION STILL FACES TECHNICAL LIMITS. Robots for rehabilitation, science confirms, could represent an adequate solution to deliver cost-effective therapy that is intensive, interactive, challenging and personalized. The main drawback is that robots for rehabilitation cannot be used outside of the hospital, and so they are precluded to chronic stroke patients.As a result, chronic patients hold potential for motor recovery, but they don’t have access to adequate treatment (robots).ICone: SCALE-UP OF ROBOTIC THERAPY. Heaxel produced ICone, the first portable robot for the neurorehabilitation of the upper limb, cleared for use outside of the hospital. All the ICone robots will be connected all together into a cloud network, so to facilitate the access of chronic patients to robotic therapy.FEASIBILITY STUDY. A Phase I project will allow to carefully organize customer development activities and go-to-market strategy. The business feasibility of different revenue models must be tested, to quickly and effectively start the commercialization of the robot, in order to deliver the best possible care to chronic patients. This Phase I study will be crucial, then, for an EIC acceleration project, where pilot clinical trials will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CELLulose nanocomposite separators for the nEXt generation of smart batteries' in the context of a Horizon Europe call.

assistant: **Objectives**

As the popularity of electric vehicles continues to increase, so does the number of batteries reaching the end-of-life that are used to power them being expected that by 2030 it will reach 2 million tons worldwide. On top of this the complexity of battery production results in very high scrap rates (about 10%-30%), especially during production ramp-up, while the scarcity of raw materials in Europe are intensifying EU regulations to localize supply chains and safeguard critical raw materials. It is evident that there is strong need to increase sustainability in the batteries value chain and contributions may come from improving both their lifetime and recyclability of the cell components. In EXCELL it is proposed to prove a new concept for batteries separators based on a 100% natural cellulose nanocomposite with tuneable mesopores obtained by a mixture of nanofibers and cellulose nanocrystals.  Additionally, these new separators will be suitable for the incorporation of sensing elements that will enable the new generation of smart battery cells. EXCELL will follow the outputs of NEWFUN-StG where it was demonstrated that cellulose based ionic conductive materials are possible to be recycled and reused while maintaining the electrochemical performance. The PI’s team has also demonstrated that cellulose nanocrystals are able to create mesoporous ionic conductive channels that can be tunned to specific alkali ions but proper functionalization of the crystals’ surface. EXCELL will now demonstrate the synergic effect of combining both to form hierarchical mesoporous membranes exhibiting a unique set of characteristics that can meet those ones expected for an “ideal” separator. EXCELL will follow an approach of validating the new separator concept and then implement a IPR conso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Thresholds and tipping points in ecosystem responses to global warming' in the context of a Horizon 2020 call.

assistant: **Objectives**

Terrestrial ecosystems are important in providing key services to humankind, but under global warming the provisioning of such ecosystem services is at risk. However, there is little consensus on how the functioning of terrestrial ecosystems will change under projected scenarios of global warming, or when we will reach or surpass thresholds and tipping points. This is largely because most studies have failed to unravel ecosystem responses to increasing temperatures in terms of the underlying non-linear responses of plants, soil organisms, and their communities. Since plants and their associated soil organisms (i.e., pathogens, mutualists, and decomposers) can vary in their responses to temperature change, global warming may disrupt or decouple interactions among coexisting and co-evolved species. This may have unforeseen consequences for key ecosystem functions, such as carbon and nutrient cycling.THRESHOLD will use a novel cross-disciplinary approach to advance our fundamental knowledge of how non-linear temperature responses transcend different levels of ecological organization. Specifically, this project aims to:1) Establish a global network of forest-tundra and forest-alpine ecotone sites, to assess how responses of ecosystem carbon and nutrient cycling to global warming will be pushed across thresholds and tipping points.2) Perform mesocosm experiments under different temperatures, to estimate how ecosystem process responses to global warming can be predicted from the reordering of plant and soil communities, as well as from the functional traits that they possess and express.3) Reveal how community responses to warming and extreme temperatures can be predicted from the physiological responses of their component species.To achieve these aims, this work will utilize
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Research Network on Excellence in Processing Open Cultural Heritage' to be submitted under Sixth Framework.

assistant: **Abstract**

EPOCH will combine expertise and resources of technologists, heritage administrators, heritage professionals and communication experts concerned with the effective and sustainable application of digital technology to archaeological research and cultural heritage presentation at museums, monuments, and historic sites.The network will promote the integration of research efforts in five vital subfields:- Field Recording and Data Capture- Data Organisation, Provenance and Standards- Reconstruction and Visualisation- Heritage Education and Communication- Planning for sustainability of heritage projects.EPOCH involves a large consortium of leading European institutions and will promote interdisciplinary integration by initiating and supporting a wide range of activities to the benefit of network members and the wider community, including:1) Undertaking integrating activities to create an integrated information base on the current and potential use of ICT in cultural heritage, the obstacles to progress in terms of both the technical research terms and the understanding of the socio-economic and business issues and to enhance use of existing resources.2) Performing research to complete the toolkit for creating cultural heritage applications and create an integrated infrastructure3) Spreading Excellence through on-line services and resources, dissemination activities, education, training and staff mobility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Galaxies entering a cluster' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content In a galaxy cluster there are two different kinds of interaction: Galaxy-cluster interactions and galaxy-galaxy interactions. Both lead to changes in the global properties of the galaxies. Observationally, it turns out that the apparent galaxy structures are functions of their respective location within the cluster. Outer galaxies are less disturbed than inner ones. Thus galaxies entering the cluster suffer from severe interactions with the cluster environment. This fact will be used to distinguish and model the influences of these interactions on the galaxy's gas content. Furthermore, we plan to study the influence on the other components of the galaxy, as well as influences on the ensemble of galaxies as a whole. We will model galaxies-by means of a 3 component N-body code including self-gravitation and inelastic coIlisions. Thus we will be able to study the interactions described above in detail in order to draw new conclusions about the formation and development of galaxies in clusters and maybe of galaxies in general. Training content (objective, benefit and expected impact) At the same time, this project will deal with the modelling of galaxies and the reduction and evaluation of observational data. These results will be published in scientific journals. They will be also made available in colloquia to other scientists and students. Furthermore, the so developed code can be used in a modified form to solve related problems. For this purpose the code will be put into the public domain. Links with industry / industrial relevance (22) There is no direct relevance due to the nature of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enzymatic and genomic targets of histone modifying enzymes and their role in liver metabolism and hepatocarcinogenesis' (SET-NET).

assistant: **Innovation**

In this proposal we will study the role of histone methytransferases Set9, PR-SET7, Smyd2, Smyd3 and the demethylase LSD1 in hepatocarcinogenesis and in the regulation of hepatic metabolic pathways.The hypothesis raised here suggests that the function of histone modifying enzymes is realized through 4 overlapping regulatory layers: i. via modifications of chromatin, ii. via modifications of recently identified transcription factor substrates, iii. via influencing the hepatic transcription factor crossregulatory circuitry, and iv. via modification of each other.To dissect the role of these regulatory layers and determine their contribution in the control of hepatic metabolic pathways, and in the development of hepatocellular carcinoma, our activities will involve: i. Generation of relevant KO and transgenic mouse models, ii. Functional characterization of novel non-histone and histone substrates, iii. Analysis of novel cross-regulatory protein modifications affecting the activity of the enzymes and iv. the identification of their genomic targets and associated chromatin modifications using global approaches.The work is expected to provide important insights into a previously unanticipated network of protein methylation-directed regulatory modules, potentially operating in multiple biological pathways such as liver development, metabolism, apoptosis and carcinogenesis. The functioning of such network would be of high biological importance, with far-reaching implications in drug development, rivaling those of phosphorylation or acetylation regulated processes.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Regional Action for Logistical Integration of Shipping across Europe'.

assistant: **Concept**

The principal objective of REALISE is to develop European strategies and initiatives to promote the use of short sea shipping, sea-river shipping and inland navigation in the context of the overall logistics market, particularly for the carriage of unitised cargoes, ensuring a shift in freight transport from land to water in a multi-modal context. The intention of REALISE is also to demonstrate that the expansion of waterborne transport will include benefits from reductions in fuel use; reduced environmental damage and road congestion; an improvement in the overall safety of the European transport system; the promotion of sustainable technologies in the waterborne transport sector, and intra-European economic and social cohesion. REALISE will aim to identify and bridge the gap between RTD and industrial needs to ensure the effective integration of waterborne transport in multi-modal transport chains and the identification of technological gaps where further RTD is required.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Uncertainty principles versus localization properties, function systems for efficient coding schemes' (UNLocX) under Seventh Framework.

assistant: **Objectives**

Algorithms in signal and image processing have reached an impressive level of sophistication and computing power still increases at an exponential rate. However, high-tech applications have an ever-increasing demand for even more efficient algorithms, even more powerful computers and new concepts for advancing applications.Starting from a recently discovered gap in the theory of uncertainty principles, this project aims at developing a framework for constructing problem adapted, ultra-efficient algorithms concerning (de-)coding and analyzing/synthesizing signals/images. We expect, that this will allow us to tackle complex applications in life sciences and ultra precise audio signal processing which presently cannot be solved appropriately with existing algorithms on existing computers.The key for developing these algorithms is a representation of signals and images by function systems, which satisfy the following requirements:1.\tOptimal localization,2.\tEfficient discretization.The theoretical foundation of this approach is based on the definition of suitable localization measures in generalized phase spaces and the construction of minimizing waveforms. These waveforms are then the basic building blocks in discretization schemes.We expect that this approach allows us to shift the limits of the efficiency vs. precision paradigm considerably. The efficiency of an abstract algorithm has to be evaluated in connection with the computer hardware (parallelization, data exchange, storage) used. Accordingly, our proof of principle includes implementations of baseline algorithms as well as of advanced GPU implementations.As final proof of principle we apply these methods for two challenging applications in audio signal design and life sciences (proteomics). The evaluation will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EXPANDING THE KNOWLEDGE ON MAMMALIAN ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION (ERAD)' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The misfolded, unfolded or unassembled proteins in the Endoplasmic Reticulum (ER) are degraded by the “Protein Quality Control Mechanism” named as ER-associated degradation (ERAD). In addition to its safeguard role, ERAD can regulate physiological processes that occur in the ER, for example degradation of HMG–CoA reductase, the key enzyme of cholesterol synthesis. ERAD is a multistep process, which starts with substrate (unwanted protein) selection followed by ubiquitination, retrotranslocation, deglycosylation and proteasomal degradation. Aberrant ERAD has implications on several diseases, such as cystic fibrosis, a1-antitrypsin (AAT) deficiency, diabetes, neurodegenerative diseases and cancer.The details of ERAD mechanism are very well known through the studies in S.cerevisiae. Although the general scheme of the pathway is similar, ERAD is more complicated and highly regulated in mammals than in yeast. Studies in yeast suggested existence specialized ERAD pathways depending on the feature of the protein. These pathways are: ERAD-C ( for cytoplasmic misfolded domains), ERAD-L (for luminal misfolded regions), ERAD-M (for membrane misfolded regions). So far, this issue has not been studied in mammalian cells. Here, we intend to identify substrate specific differences present in retrotranslocation machineries in mammalian ERAD using four substrates with different structural features. Additionally, the effect of SVIP (the first identified endogenous ERAD inhibitor) on these substrates, the role of Npl4 in gp78-mediated ERAD and possible functional interaction of gp78 and hHrd1 enzymes will be examined.  This research will provide the first information on the substrate specific differences of mammalian ERAD, and also the functional interaction between two important ER-resid