RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Characterization of the role of morphogens during growth of the Zebrafish pectoral fin using advanced biophysical tools'.

assistant: **Objectives**

During development an organ grows to a final size and shape and its cells acquire information about their position and differentiate according to their location. Morphogens play an important role in this process by coordinating growth and patterning of developing tissues. In this project the fellow will fully characterize the growth of the pectoral fin of the Zebrafish, a vertebrate, and study the role morphogens play herein, using a multidisciplinary, quantitative, biophysical approach. First, the kinetic parameters of growth during embryonic pectoral fin development will be quantified. For this purpose the fellow will establish a Digital Scanned Light-Sheet Fluorescence Microscope and transgenic Zebrafish expressing GFP-based mitotic phase biosensors. Next, the morphogen gradient parameters during the fin growth phase will be quantified using two-photon, spinning disc and DSLM microscopy. The fellow will establish transgenic Zebrafish lines expressing functional GFP fusions of the morphogens. The transport parameters of the morphogens will be quantified by performing FRAP and Photoactivation of the morphogens fused to suitable fluorescent proteins. Finally, he will quantify the signal transduction response to the morphogen, by using or establishing signaling biosensors for the different morphogens. By these four different approaches a comprehensive, quantitative picture of fin growth and the progression of morphogen gradients will be obtained. It will ultimately allow us to understand the underlying cell biology of gradient formation and how morphogens control patterning and growth in a relatively simple model system. The field of quantitative developmental biology is a new and emerging field. It therefore needs young researchers who are trained in this field. With th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cortical Disorganization in Psychosis. Neurophysiological, clinical and genetic factors""' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Background: Schizophrenia and bipolar disorder are severe mental illnesses which cause high rates of disability, social and economic costs. Although there is compelling evidence of a genetic contribution to psychosis and we know deficits in neuronal connectivity are a key factor, the pathophysiology and aetiology of the disease remain poorly understood. Aims: (i) To identify biomarkers of neural dys-connectivity characterising psychosis through neurophysiological and neuropsychological techniques. (ii) To apply such biomarkers in genetic association studies in order to understand the mechanisms by which variation at certain loci leads to the onset of the disease. Methods: Neurophysiology is a non-invasive and inexpensive technique with a superb temporal resolution that allows the study of perceptual and cognitive processes in vivo. My UCL supervisor and I have collected a large sample of families with psychosis cases including 300 patients, 220 unaffected relatives and 300 controls. Participants completed a battery of experiments including resting EEG, P300 wave, P50 gating, Mismatch Negativity and cognitive assessments. I will train in advanced analytics using Dynamic Causal Modeling (DCM), which tests models of neural activity and its synchronisation deficits and is a new tool in psychiatry. Through DCM I will identify novel measures of brain dys-connectivity to use as phenotypes for genetic association. I will examine candidate genes, identified through association studies using Plink and Unphased software. I will train in gene ontology tools to perform pathway analyses using the extensive genome-wide genotyping that is already available on my sample. UCL, a centre of excellence in neuroscience, will host my research. Implications: Biomarkers of brain connectivity co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Testing macroecological theory using simplified systems' (CAWEB).

assistant: **Innovation**

Community assembly, how they change in space and time, and how they will be affected by global threats, is one of the most pressing issues in ecology and conservation biology. To fully understand assembly rules and community change, one has to delve into multiple interrelated factors, such as the history of environmental and habitat changes in the past, current biotic and abiotic factors, spatial constraints and future scenarios for all these. Yet, two factors have prevented us from obtaining a complete picture for any organism. First, communities are extremely complex, typically encompassing thousands of species and millions of interspecific interactions. Second, future scenarios are overwhelming to model without the challenge of dealing with chaotic systems, where even small changes can lead to large, unpredictable, consequences. Here, I propose to use cave communities as the simplest and easiest setting to model assembly rules and future change across space and time. Caves offer unique opportunities for eco-evolutionary studies because they are characterized by a low abundance and diversity of organisms and interactions, they receive limited external inputs and are easily modelled. By combining a range of state-of-art algorithms and computer simulations, I will investigate the eco-evolutionary processes that shape functional and taxonomic diversity in subterranean spider communities at a continental scale, as well as the sensitivity of specialised species to climate alterations. I will rely on extensive datasets already collected and try to answer the question: what drives community assembly across space and time, and how can we predict the consequences of climate change on current biomes?. The project will be implemented at the Finnish Natural History Museum, and wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Home based Augmented Reality Platform for Efficient Rehabilitation of stroke patients' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Brain Stimulation AB is a Swedish SME started in 2011 with the aim of exploiting brain plasticity results from research withina new concept of rehabilitation and diagnosis of cognitive impairments of attention in stroke patients (the NeglectSyndrome). We address the global challenge of rehabilitating patients with cognitive and upper limb problems from Stroke,Dementia, Traumatic Brain Injuries, Parkinson and other degenerative brain diseases. Cognitive impairments as in theNeglect Syndrome is not discovered nor treated in suitable time and the normal hospital stay is too short to rehabilitate thepatients properly. Our innovation meets the need of early detection and diagnosis as well as efficient rehabilitation ofpatients in clinics and that can continue in patients’ home environment. If the Neglect Syndrome is discovered and treatedfaster and better than today, the wellbeing of patients will increase. The burden and the costs for their care will besignificantly reduced. Around 30% of the 16 Million new stroke patients worldwide per year suffer from the NeglectSyndrome i.e. there are 5-6 million new patients per year. Our addressable market exceeds 6 Million patients per year as ourambition is to reach not just the stroke patients with Neglect Syndrome but also Dementia, Traumatic Brain Injuries,Parkinson and other degenerative brain diseases. The innovation project will lead to a generation of €10,3 Million in turnoverand creating 40 new job positions in a five-year perspective after market-launch as well as creating IP rights from theoutcome of the Project. The goal is to develop, verify and bring our innovation towards global market launch. We will gofrom TRL 6 towards TRL 9 during the full innovation project life cycle. There will be sustainable effects in economic,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Graded constraints in semantic cognition: How do we retrieve knowledge in a flexible way?' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

For any concept, we have knowledge about diverse features – for example, a dog is furry, can chase rabbits, and is “man’s best friend”. How, at a specific moment, do we flexibly retrieve relevant conceptual knowledge that suits our current goals and context? We can promote coherence between weakly-related aspects of knowledge as required, and also achieve the timely release from patterns of retrieval when the situation changes. These effects are likely to play a central role in our mental lives – yet they are poorly understood because past research has largely focused on how the conceptual store captures what is generally true across experiences (i.e. semantic representation). This project alternatively examines the cognitive and brain mechanisms that promote currently-relevant semantic information. We consider whether flexible semantic retrieval involves the recruitment of additional brain regions, organised within large-scale distributed networks, that place constraints on patterns of retrieval in the semantic store. In this way, semantic flexibility might relate to the evolving interaction between distinct brain networks. We examine whether specific brain regions support distinct cognitive processes (e.g., “automatic retrieval”; “selection”) or, alternatively, whether the functional organisation of these networks is non-arbitrary, with brain regions further away from the semantic store supporting retrieval when there is a greater mismatch between ongoing retrieval and the pattern required by the context. We test this “graded constraints” hypothesis by combining parametric manipulations of the need for constraint with convergent neuroscientific methods that characterise functional recruitment in space (magnetic resonance imaging) and time (magnetoencephalography). We
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Parallel photogrammetry system for object panoramas', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The preservation of cultural heritage by using digitization techniques is a very common method used by many European countries nowadays. The digital 3D modeling offers users the most realistic and trustworthy way of preserving precious artifacts from the various areas such as: history, art, biology, etc. The digital 3D models have wide application in science, education and industry. The most accurate method of creating realistic 3D models is panorama photography, which offers users a precise way of capturing reality. The only method of creating the digital 3D model from panorama photography is photogrammetry, however currently available methods of processing and computing might be considered as very time consuming and not reliable.Parallel photogrammetry system (PAPHOS) serves the need for processing high-resolution object panoramas into digital 3D models. The whole system continuously processes object panoramas from EDICO´s digitization system WITIKON with high resolution and special boundary conditions. This novel approach rapidly increases visual quality and decreases the time of 3D model computation due to using parallel photogrammetry algorithms.Whole computing is performed in the cloud or local CPU/GPU cluster. Project reacts to customer needs, such as less time consuming operations in the computing process and possibility of photogrammetry parameters change, better control of final 3D model, and possibility of using cloud computing. Problems outlined and solutions proposed are based on our previous research projects in the field of cultural heritage digitization.With PAPHOS system EDICO SK plans to grow up in the terms of its team (+ 15 employees by 2021) and sales (+ 3,6 M € of revenue in 2021) by targeting markets in the field of cultural heritage on EU-scale a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multi-particle scattering amplitudes for precision collider physics' (MPAmplitudes), addressing dissemination and exploitation.

assistant: **Impact**

Scattering amplitudes determine the probability of interactions between fundamental particles.  They are essential ingredients for phenomenological predictions in high-energy physics.  Experiments at modern colliders, such as the Large Hadron Collider (LHC) at CERN, are probing fundamental interactions at previously unexplored scales of energy.  The high energy involved in these interactions is responsible for the production of many particles in the final state, which needs to be theoretically understood with high accuracy in order to make the most out of experimental data.  The goal of this research project is the analytic calculation of multi-particle scattering amplitudes at higher orders in perturbation theory, and in particular the two-loop five-point amplitudes in quantum chromodynamics, needed for theoretical predictions at next-to-next-to-leading order in perturbation theory.  These are of great relevance for LHC phenomenology, since our success in finding new physics can depend on our capability of distinguishing its effects from the large QCD background of multi-particle processes, which needs to be known with high precision.  The method used for the calculation builds upon state-of-the-art techniques, such as multi-loop integrand reduction and generalized unitarity.  These techniques exploit the knowledge of the universal analytic and algebraic structure of amplitudes, and are suited for handling the complexity of multi-particle calculations.  The technologies and tools which will be developed for this project are very general and will thus provide a framework useful for future precision calculations, opening up a new frontier for high-precision multi-particle theoretical predictions for collider experiments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Resilience of coworking spaces'.

assistant: **Objectives**

RECOS proposes a comprehensive and innovative way of understanding key factors contributing to urban resilience of coworking spaces (CWS) under the impact of external shocks. However, dynamic perspective and supply-related aspects of CWS aspects are not fully understood. Therefore, RECOS aims at addressing knowledge gaps regarding the lack of longitudinal, spatial perspective on the resilience of CWSs on the intra-urban level and the dynamics of the coworking location and shifting location factors as well as knowledge gap regarding the underrepresentation of the demand perspective, namely hybrid-workers, with regard to urban location strategies.RESOS foresees to address these objectives and gaps by a) creating CWS resilience assessment framework; b) mapping location patterns and location factors of CWS; c) designing a prototype online platform that exploits spatial syntax for optimising individual work location strategies. Training programme implemented at TUDelft and supervised by prof. dr. Hilde Remy, associate professor with 15 years of experience in research on adaptive reuse of real estate, will allow me to diversify my individual competences. RECOS will enhance my career and leadership capabilities in project management through interdisciplinary research, improve implementation of experimental design techniques, and improve academic writing for publication purposes.A two-way transfer of knowledge is guaranteed since RECOS combines my expertise in policy and demand factors of CWSs resilience with the hosts expertise in urban design and supply factors of CWSs resilience. Impacts include empowering individuals in informed life-work choices, knowledge on remote work, commuting, improved CWS profitability and occupancy. Therefore, RECOS will contribute to Europes knowl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fundamental Building Blocks –  Understanding plasticity in complex crystals  based on their simplest, intergrown units' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

New structural materials with higher strength and temperature capabilities are the key enablers of sustain-able energy conversion and transport technology of the future. The question is: How do we find those central high-performers combining high strength and the essential deformability giving safety in application? It is the aim of FUNBLOCKS to provide the first systematic studies of plasticity mechanisms in the most fundamental building blocks of complex crystals. These will allow us to deduce the missing basic mechanisms and signatures of plasticity. FUNBLOCKS will take a new approach by studying the much simpler sub-units that form the multitude of more complex crystals with large unit cells amongst the intermetallics. This has three major implications: i) the reduction to fundamental units allows suffi-cient time to unravel the major deformation mechanisms to the atomic level, ii) the recurrent nature of the few fundamental building blocks will allow a transfer of this knowledge to a large number of complex phases and iii) together, this will enable data mining from the vast and largely unexplored phase space of intermetallics.The key aspect of FUNBLOCKS is therefore to close the existing gap in knowledge and allow us to find promising new phases by elucidating the fundamental relationships between crystal structure and plasticity beyond what we know in simple metals. To identify and quantify the intrinsic mechanical properties of each sub-unit, state-of-the-art micromechanical testing techniques will be used. Transfer of data and verification of the central hypothesis, that fundamental units govern plasticity in complex crystals, will be achieved via additional alloyed crystals forming ternary variants of the binary structures.Ultimately, FUNBLOCKS will answer fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ultrastructural analysis of phosphoinositides in nerve terminals: distribution, dynamics and physiological roles in synaptic transmission' (ALPINE).

assistant: **Innovation**

Phosphoinositides (PIs) are minor components of cell membranes, and play important roles in cellular functions. In chemical synapses in mammalian brain, each PI distributes different subcellular areas in nerve terminals, and cooperate with many proteins to regulate synaptic transmission machinery. To understand how PIs regulate synaptic transmission, the ultrastructural distribution pattern and dynamics of PIs at nerve terminals are crucial because PIs may functionally interact with proteins at domains of nano-meter ranges called active zones (AZs) or peri-AZs. However, their ultrastructural distribution and dynamics in nerve terminals are poorly investigated because of some technical difficulties. This research project aims to investigate (1) the ultrastructural distribution of PIs at AZs and peri-AZs in nerve terminals, (2) co-localization of PIs with presynaptic proteins related to synaptic transmission, (3) the ultrastructural dynamics of PIs and PI-protein coupling during synaptic transmission, and (4) the physiological roles of PI-protein couplings in synaptic transmission, using electron microscopic and electrophysiological techniques combined with optogenetics and biochemical tools. These highly-interdisciplinary approaches will unveil the physiological roles of PIs and PI-protein couplings in synaptic transmission, and is expected to give a fundamental breakthrough in understanding mechanisms of synaptic transmission.