RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular investigation on the origin and genetic stability of human t-lymphotropic virus type ii - htlv-ii e' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Human T-lymphotropic virus type I and II (HTLV-I and -II) are retroviruses associated with neurologic degeneration and leukemia in a small part of infected individuals. HTLV-II is now spreading among intravenous drug users in Southern Europe, threatening the blood banks. The origin of these human retroviruses and the reasons for their observed genomic stability are not known. We have access to a unique African reservoir of endemic HTLV-II among Bambuti pygmies from Zaire. Sequencing this viral genome will allow us to investigate the origin of HTLV-II. The reverse transcriptase of this virus will be cloned and expressed to be able to investigate its fidelity as a possible reason for the extreme genetic stability of this retrovirus. Possibly, a reverse transcriptase with a high fidelity could result from this research, which could become a useful tool in molecular biology research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transnational family networks: an analysis of care-giving arrangements within migrant families' (Transfam) targeting Seventh Framework.

assistant: **Abstract**

This project aims to further develop theoretical and empirical knowledge on the interrelationship between geographic distance, care practices and family relations. The specific question this study addresses is the extent to which transnational adult migrants are able to exchange care and support with their geographically distant parents, and the specific role that intrafamilial dynamics play in the exchange of care between adult migrants, their siblings and their parents. This will be done by analyzing the experiences of Dominican migrants in Belgium and their geographically distant kin. The study will focus on three types of care-giving arrangements: long distance care-giving (provision of support from a distance) ; aged migration (permanent or temporary migration of dependent elderly parents in order to be cared for by their child(ren) in the host country) ; and migrants repatriation (migrants moving back home to care for their parents). Particular attention will be paid to gendered dynamics and power relations within the families, as well as other structural factors that influence decisions regarding each type of care-giving arrangement. Fieldwork will include semi-structured interviews and participant observation with Dominican migrants residing in Belgium, their parents (father and/or mother) and up to 2 key siblings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ring laser gyroscopes for ground motion sensing' (GyroRevolutionPlus).

assistant: **Concept**

Sensors for rotation are ubiquitous in our daily life, ranging from consumer electronics to navigation systems. Applications that require highest sensitivity for very small rotation rates rely on active ring laser gyroscopes (RLGs) or fiber-optic gyroscopes (FOGs). These devices, however, suffer from intrinsic bias drift and do not reach the sensitivity requirements of applications such as seismology and monitoring of ground motion.Out of the parent ERC project on optical precision measurements grew the innovative concept of a three-dimensional array of so-called passive RLGs which would be entirely fiber-coupled and digitally controlled. This concept circumnavigates the shortcomings of previous designs and has the potential to reach the low drift rates at high sensitivity required in the field of environmental sensing. Such a scalable device would have a revolutionary impact on natural disaster early warning systems, in particular earthquakes and landslides, and structural health monitoring, each with a market size in excess of 2 bn USD.In preliminary work, we demonstrated the feasibility of our approach and tested individual technology packages outside the lab. A market analysis has been issued, and the IPR situation has been clarified. With no patents close to our innovation, we filed patent applications for a total of six individual inventions and methods of our approach.Within this project, we will prepare the ground for a successful market entry. Objectives of GyroRevolutionPlus include the removal of remaining uncertainties related to FPGA selection and performance, operation of the RLG outside the lab (TRL 5-6), drafting a go-to-market strategy, and selecting business partners for a reliable supply chain. We will assemble a powerful team to drive the founding of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tropical Peatlands and the Carbon Cycle' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Tropical peatlands are the most carbon-dense ecosystems in the world and they store the equivalent of ~10 years of global anthropogenic CO2 emissions. Despite their importance, crucial questions remain about carbon cycling in tropical peatlands and improving understanding is critical as they are at high risk from climate change and drainage for oil palm cultivation.TroPeaCC will provide a step-change gain in our understanding of tropical peatland functioning and in projecting their response to climate change. PI Gallego-Sala will use her unique background that bridges peatland modelling and observations to deliver a novel interdisciplinary approach to tackle four outstanding questions about tropical peatlands:Q1: What controls the geographical distribution of peatlands in the tropics? TASK1: To assess the tropical peatland extent using a combination of models Q2: How large is the tropical peatland CO2 sink and what are its main climatic drivers? TASK2: To characterize the drivers of carbon accumulation rates in tropical peatlands using the palaeo-archive. Q3: How large is the methane flux in tropical peatlands? What are the main controls at the intercontinental scale? TASK3: To determine the main controls on methane fluxes in tropical peatlands, using eddy covariance, chamber-based gas flux measurements, and ground penetrating radar.Q4: What is the overall carbon balance of tropical peatlands and how will this change in the future? TASK4: To forecast future changes of the extent of tropical peatlands, of the carbon sink and of  methane emissions, using the results of Tasks 1-3 to parameterise and evaluate a global dynamic vegetation model that includes tropical peatlands for the first time.The interdisciplinary approach will lead to a comprehensive understanding of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Harnessing snap-through transition waves in multistable metamaterials for fluid-transport applications' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In the last decade, flexible mechanical metamaterials have demonstrated their great scientific potential. By exploiting mechanical instabilities in such structures, researchers have observed the propagation of transition waves yielding both fundamental implications (analog material to understand ferroelectric phase transitions, dislocation motion in crystals) and engineering applications (elective signal transmission, acoustic insulators). Most studies focus on the properties of the waves at the metamaterial level, without analyzing the details of the transition at the building block level. As a result, the mechanisms that govern the propagation of these waves remain poorly understood, which greatly limits their range of application. In this research project I propose a bottom-up approach to investigate this class of phenomena. Specifically, I will experimentally and numerically study the overlooked mechanisms of the snap-through instability of a single bistable arch. This will allow me to design a 1D array of such arches connected via rotating hinges in which an elastic snap-through wave can propagate. I will then put to test this new knowledge in the rarely explored domain of fluid-structure interaction with mechanical metamaterials. Specifically, I propose to exploit these elastic waves for fluid transport applications via peristaltic pumping. This project will yield general rules to design structures that propagate controlled transition waves, and will open new avenues for their use in interaction with fluids.


**Keywords:** elastic instability, fluid-structure interactions, non-linear waves
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Systems Biology of the Heterobasidion-Spruce Interaction: Application of Metabolomics and Genomics to Understanding Host Resistance' (SYBHES) under Seventh Framework.

assistant: **Objectives**

Root and butt rot of conifers caused by Heterobasidion is one of the most important tree diseases in the northern hemisphere. Despite the high impact of Heterobasidion, ability to control the disease in forests with a long history of management is very limited. Traits associated with resistance to pathogen growth appear to be highly heritable, and could be exploited in selection and breeding programmes. However, neither the molecular control nor the biochemical basis for this resistance is known in Picea species. This project will utilise state-of-the art metabolomics and genomics methods to elucidate biochemistry and gene regulation in Sitka spruce (Picea sitchensis) challenged with Heterobasidion annosum, in relation to lesion development and extension growth of the pathogen in bark tissues. Responses of six mature Sitka spruce clones differing in susceptibility/resistance will be assessed after wounding and artificial inoculation with three isolates of H. annosum differing in virulence at 0, 3, 7, 21 and 35 days after treatment. Bark tissues surrounding the wounding and inoculation points will be analyzed for phenolic and terpenoid components using LC-MS-based metabolomic techniques to identify changes in the metabolome of spruce bark and pinpoint key constitutive and induced differences between resistant and susceptible host genotypes. Key genes in metabolic pathways identified as upregulated in metabolomics will be examined in detail using gene expression analyses based on quantitative PCR. This project will increase our knowledge of the physiological processes involved in resistance of spruce to infection by Heterobasidion, enabling accurate and rapid identification of host genotypes showing greater resistance to the pathogen. Such resistant clones will be of very
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Zinc Oxide For TeraHertz Cascade Devices' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The terahertz (THz) spectral region, located between the infrared and the microwave regions, is known as “the THz gap” because of the lack of compact semiconductor devices. This spectral domain is currently intensively explored in view of its potential for medical diagnostics, security screening, trace molecule sensing, astronomical detection, space-borne imaging, non-invasive quality control or wireless communications. A prerequisite for public-domain applications to emerge in the strategic THz frequency range is the availability of compact size semiconductor sources operating at room temperature, which is out of range of the current technology based on GaAs quantum cascade lasers.ZOTERAC proposes a disruptive approach based on ZnO-based nano-engineered semiconductors in order to realize THz emitters operating at room-temperature with milliWatt output power capability as well as THz quantum detectors with unprecedented large operating temperatures. These devices are based on the quantum cascade concept and take benefit of the large optical phonon energy of ZnO (twice that of GaAs) for achieving high temperature operation. Establishing a new state-of-the-art for the design, growth and processing of ZnO/ZnMgO heterostructures, and developing an advanced know-how on oxide-based devices are major challenges of the project. The consortium regroups world–class academic experts on ZnO technologies, quantum cascade lasers and detectors as well as THz optoelectronics. The strategies have been chosen based on a careful assessment of the risk attached to all tasks and achievement of targeted objectives at each stage of the project. This project which implies a strong expertize in basic physics, chemistry and engineering, is expected to generate high impacts in terms of scientific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biochemistry of leukotrienes, inflammatory and allergic mediators in the arachidonic acid cascade', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The objectives of the present project are to study cellular and molecular mechanisms of leukotriene biosynthesis. The work is divided into two major sections, i.e., 1. Structure and function of enzymes in leukotriene biosynthesis, and 2. Cellular regulation of enzyme activities and gene expression. Consequently, it will address the issues of activation, maintenance and regulation of the cascade with the ultimate goal to understand and gain control of the biosynthetic machinery.Leukotrienes, a family of paracrine hormones within the arachidonic acid cascade, are regarded as powerful chemical mediators of allergic and inflammatory reactions. Several lines of evidence point to a crucial role of leukotrienes in the pathophysiology of respiratory problems and asthma. Hence, to control the biosynthesis and actions of leukotrienes is one important therapeutic strategy in the treatment of asthma and related inflammatory and allergic diseases. An important effort will be made to characterize, at a molecular level, central enzymes and other cellular factors involved in leukotriene biosynthesis. This work includes enzyme purification and characterization, molecular cloning of both cDNAs and genomic sequences, gene promoter characterization, expression of recombinant enzymes, and site-directed mutagenesis. Detailed information on functional elements and catalytic mechanisms of individual enzymes is expected to be instrumental for the design of more potent and specific enzyme inhibitors, which can be developed into novel anti-asthmatic drugs. Using cellular models of leukotriene biosynthesis, expression of enzyme activity, protein and mRNA will be studied and the potential effects of post-translational modification of enzymes, cytokines, degree of cellular differentiation/maturation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular analysis of drosophila cell division' (MADCD) under Fifth Framework.

assistant: **Objectives**

Mitotic errors and genome instability are major contributing factors to malignant transformation. Loss or gain of entire chromosomes, or stable chromosome fragments generated by all sorts of rearrangements, play an essential role in the unbalance of gene products that contributes to malignancy. The importance of aneuploidy in the progression of a cell to the cancerous state is well established. Aneuploidy can be generated by defects in either the kinetochore, the mitotic apparatus or the spindle checkpoint. Another mitotic structure that has been implicated in cancer etiology is the centrosome. Centrosome abnormalities have now been reported in many tumors and many oncogenes and tumor suppressor genes have been found to be associated with the centrosome at different stages of the cell cycle. Finally , it has been proposed that multinucleated cells produced by failure of cytokinesis would give rise to aneuploid mitotic products that would promote carcinogenesis The research to be undertaken is aimed at a further understanding of the molecular mechanisms that underlie genomic stability in higher eukaryotes.The aim of this proposal is the study of the above topics using Drosophila melanogaster as a model organism. Using a variety of integrated genetic and biochemical approaches we plan to analyze(1) the spindle checkpoint machinery,(2) the regulation of centrosome activity,(3) the centrosome and its interacting proteins and(4) the mechanisms of cytokinesis. Given the high degree of evolutionary conservation of genes involved in cell division, our findings should provide the basis for identifying genes that govern the mitotic process in human cells. The discovery of such genes should extend our knowledge of cancer etiology and provide a potential basis for therapeutic inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bismuth Redox Catalysis for Sustainable Organic Synthesis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Homogeneous catalysis based on transition metals has become an indispensable strategy in the development of efficient methodologies for organic synthesis, finding application in a wide variety of processes across the chemical sciences. Inspired by the wealth of reactivity in this area, we present a proposal that departs from transition metal catalysis and aims at unlocking the potential of bismuth (Bi) as a sustainable catalyst, unravelling novel and unknown catalytic redox processes for organic chemistry. The main goal of this project is to translate the unique properties traditionally associated to transition metals to a main group element. Let-it-Bi is a quest to disclose the remarkable potential of a commonly overlooked element of the periodic table such as bismuth, in the field of catalysis and organic synthesis. Being an earth abundant, non-toxic and inexpensive element, bismuth represents an excellent candidate to be explored in catalysis and to study its fundamental reactivity. In the first part of this proposal, we describe the design of a novel Bi(III)⇄Bi(V) redox cycle towards the formation of synthetically relevant and challenging C‒C, C‒Halogen, C‒N and C‒O bonds. The last part proposes the expansion of this concept to an unprecedented Bi(I)⇄Bi(III) redox cycle. Such a unique redox system will find application in the activation of small molecules (H2, NH3, B‒H and Si‒H bonds) for the functionalization of simple and largely available olefins. In addition to provide a solution to the price, toxicity and environmental issues associated to transition metal-based transformations, this proposal aims at the exploration of uncharted territories in the area of homogeneous catalysis; thus discovering and providing novel reactivities for organic synthesis which remain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Cuts and decompositions: algorithms and combinatorial properties'.

assistant: **Concept**

In this proposal we plan to extend mathematical foundations of algorithms for various variants of the minimum cut problem within theoretical computer science.Recent advances in understanding the structure of small cuts and tractability of cut problems resulted in a mature algorithmic toolbox for undirected graphs under the paradigm of parameterized complexity. In this position, we now aim at a full understanding of the tractability of cut problems in the more challenging case of directed graphs, and see opportunities to apply the aforementioned successful structural approach to advance on major open problems in other paradigms in theoretical computer science.The specific goals of the project are grouped in the following three themes.Directed graphs. Chart the parameterized complexity of graph separation problems in directed graphs and provide a fixed-parameter tractability toolbox, equally deep as the one in undirected graphs. Provide tractability foundations for routing problems in directed graphs, such as the disjoint paths problem with symmetric demands.Planar graphs. Resolve main open problems with respect to network design and graph separation problems in planar graphs under the following three paradigms: parameterized complexity, approximation schemes, and cut/flow/distance sparsifiers. Recently discovered connections uncover significant potential in synergy between these three algorithmic approaches.Tree decompositions. Show improved tractability of graph isomorphism testing in sparse graph classes. Combine the algorithmic toolbox of parameterized complexity with the theory of minimal triangulations to advance our knowledge in structural graph theory, both pure (focused on the Erdos-Hajnal conjecture) and algorithmic (focused on the tractability of Maximum Indepe