RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Origins, proliferation and pathogenesis of L-form (cell wall deficient) bacteria' (OPAL).

assistant: **Innovation**

Jeff Errington is a bacterial molecular cell biologist with nearly 30 years of research experience. He spent much of the first 15 years or so working on spore formation in B. subtilis as a simple model for development and differentiation. His lab developed a method with which to clone the complete set of sporulation genes and then contributed in a major way to working out how sporulation is controlled spatially and temporally. Work on the spatial control of gene expression and protein localization led him to pioneer some of the methods of digital imaging of bacteria on which the modern field of bacterial cell biology was founded. He has contributed in a major way to understanding the division machinery of bacterial cells and particularly how division is restricted to the correct mid cell position. Errington made the seminal discovery that bacteria have true homologues of actin (MreB proteins) and showed that MreB filaments govern cell shape by directly organising the cell wall synthetic machinery. Recent work has opened up the neglected field of L-form bacteria to molecular and cellular analysis by developing methods to study the L-form state in a controlled way in B. subtilis. Errington has promoted the commercialization of the basic science emerging from his lab through foundation of a spin-out company Prolysis Ltd, which has developed the first cell division inhibitors with proven efficacy. Errington has founded the new Centre for Bacterial Cell Biology in Newcastle, to promote the recovery of basic science on model bacterial cells and has recruited several world leading experts to the Centre. Over his career he has helped train nearly 50 graduate students and post-docs, many of whom have gone on to become independent group leaders. He is an elected Fellow of several
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Computational methods for biological sequence analysis with application to evolution of yeast mitochondrial genomes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Modern molecular biology relies on high-throughput technologies to generate large quantities of data about components of living cells and on sophisticated mathematical and computational techniques for analyzing this data. We will develop new algorithms and probabilistic models in areas of comparative genomics, gene finding, and homology search. In particular, we propose a new class of evolutionary models for modeling changes in exon structure of protein coding genes. These models have applications in gene finding and ancestral sequence reconstruction. We will also develop more efficient methods for homology search in large databases containing families of related sequences. Finally, we will apply both existing and new methods to comparative analysis of mitochondrial genomes in Candida genus. Some of these genomes have linear chromosomes terminated with telomere-like structures similar to eukaryotic nuclear chromosomes, yet of independent evolutionary origin. By studying these sequences, we aim to address fundamental questions of evolution of linear genomes and telomeric regions, and evolution of binding specificity in DNA binding proteins. This interdisciplinary project will be carried out in cooperation with researchers from both computer science and biology at Comenius University in Bratislava.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CoolFarm – The intelligent and flexible system that provides to plants what they need, when they need it!' under Horizon 2020.

assistant: **Concept**

The objective of this project is to demonstrate the breakthrough system - SaaS based B2B Greenhouse Artificial IntelligenceControl System – which is a high-tech product to solve real world problems!CoolFarm represents the future of agriculture by bringing it into the cloud. CoolFarm is a disruptive solution based onArtificial Intelligence (AI) and Machine Learning, connected to the cloud and with an intuitive interface, adaptable to web,mobile and tablet supports, supported on an unique concept of controlling, in a precise way, the environmental variables thatcontribute to plants growth, which allows them to develop in the most healthy, efficient and effective way.Designed to nurture plants by controlling several environmental variables that have a direct impact on plant growth, Coolfarmprovides them what they need, when they need it! This state-of-the–art Plug&Play solution, has established a newbenchmark for cultivation farms making control easier and more intuitive, optimised in terms of plant growth and resourcemanagement, and as a result, more profitable, LOWER CAPEX and OPEX=HIGHER ROI (Return On Investment)!CoolFarm technology can be directly applied to two distinct markets, (i) hydroponic greenhouses which encompasseshydroponic and aquaponic urban greenhouses; and (ii) micro-algae reactors which are used to manufacture biofuels, and inthe food and cosmetics industries.The solution proposed addresses European and global challenges, as it is very attractive for SMEs and large enterprises,contributing to increasing European competitiveness, namely, (i) Increasing urban agriculture market across Europe; (ii)Enhance the increase of the biofuel market that still lacks the means to be efficient; (iii) Increase the production in industrialgreenhouses; (iv) Precision agr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cholinergic control of macrophage activation and functions' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Brain activity can modulate immune responses, but mechanisms involved have remained an enigma. Here, we will substantiate modulation of the innate immune response by the parasympathetic nervous system and evaluate the receptors and signal transduction mechanisms involved.Excessive inflammation is devastating to tissue and counter-regulatory systems are needed to keep immune responses under control. In a mouse model of intestinal inflammation, we have recently demonstrated that such a mechanism is provided by the cholinergic nervous system. Our data, and that of others, suggest that particularly the vagal nerve, the largest nerve of the body, can reflexively monitor and regulate activation of enteric macrophages (the main class of innate immune cells) via peripheral release of its neurotransmitter acetylcholine. Compared to the classically known regulation of macrophage activation via humoral pathways (i.e. cytokines), neuronal signalling can be rapid, targeted, and directly integrated. This concept is supported by in vivo as well as in vitro data, as acetylcholine negatively regulates macrophage activation via acetylcholine receptors present on these cells.In the current project we will study which receptors for acetylcholine are involved in the cholinergic nervous systems control of macrophage activation. Cellular responses of macrophages to acetylcholine, and the receptor involved will be determined. We will study which macrophage populations express the acetylcholine receptor, and how these cells respond to agonists of this receptor.Several acetylcholine receptor agonists are now used to treat neurological disorders. The efficacy of these compounds to regulate inflammatory signalling will be addressed. Also, their efficacy to ameliorate inflammatory disease will be s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Novel photocatalysts based on ferroelectric high entropy oxide-metal nanoparticle composites'.

assistant: **Innovation**

Ferroelectric high entropy oxides (FHEOs) are a novel type of ferroelectric material with the simultaneous existence of configurational entropy and internal ferroelectric polarisation. These effects combined with intrinsic lattice distortion and uneven electron-cloud distribution of high entropy oxides can lead to the generation of multiple active sites with improved separation of charge carriers, significantly impacting different photocatalytic reactions, such as pollutants degradation and water splitting. Furthermore, the visible-light-driven photocatalytic activity of FHEOs can be secured by the decoration with plasmonic metal nanoparticles (MNPs), efficiently harvesting visible light due to their localised surface plasmon resonance (LSPR). Thus, our strategy is to synthesize an entirely new FHEO and decorate it with plasmonic MNPs to produce a novel material with improved charge separation and visible light absorption, which will contribute to a major step forward in the catalysis field. The produced materials will be fully characterised and the photocatalytic efficiency will be evaluated over the degradation of pollutants present in wastewater and in the water splitting process.


**Keywords:** High Entropy Materials, Nanostructures, Photocatalysts, Ferroelectric Materials, Plasmonic Metal Nanoparticles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'International Network for Knowledge and Comparative Socioeconomic Analysis of Informality and the Policías to be Implemented for their Formalization in the Europea Unión and Latn America' to be submitted under Horizon Europe.

assistant: **Abstract**

The INSEAI project aims to create an international network for knowledge and comparative socioeconomic analysis of informality and policies to be implemented for its formalisation in the EU and Latin America. The interdisciplinary and intersectoral approach involves academic (nine from UE and seven from LA), non-academic (three from UE and four from LA), and four non-eligible funding entities. Training activities and debate events will be organised throughout secondments, and specific tools (to detect, prevent and avoid informality) will be developed with the network members and people from their environment's societal collaboration.INSEAI Network faces at least seven critical challenges currently claimed by stakeholders at HEI in Europe and LA:1)Raising the level of research organisation in the region in the informal issues covering the current state-of-the-art knowledge and formalisation governance lacks.2)Multiplying the effect of research results opens the possibility of catching public policy interest.3)Driving the PhD students' attention to informality as an endemic issue deeply rooted in the globalised dynamics changing people's lives and stratifying world peripheral capitalist positions.4)Developing Open Science,  promoting gender equality, and consolidating the network continuity.5)  Developing training tasks, exchanging knowledge and methodologies, and trying to innovate in analysis and quantification tools with the support of research and dissemination technologies.6) Managing external databases and those generated by the network to offer tools (using big data, algorithms, apps) for public use in favour of informality knowledge and estimation and the formalisation processes governance.7)Bringing together research and innovation interests from academic and civ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High performance Anaerobic digesters for the treatment of medium size wineries’ effluents' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of the AD-WINE project is to offer the opportunity for researchers from academic and industrial backgrounds to exchange knowledge and work together, in order to develop a common project in the field of anaerobic digestion and environmental solutions applied to the wine sector.This industry, which processes millions of tons of grapes every year, has consequences on the environment. The nature of the pollution generated by wineries is mainly organic, but mineral residues, earth, grease, detergents and disinfectants, toxic exogenous contaminants located in the grapes are also generated. This project aims to develop an anaerobic treatment system, using high performance digesters adapted to the treatment of medium size wineries’ effluents. The development of such digesters would help to lower the energy and operation costs of the plant, as well as significantly reducing the production of sludge and residues, and allowing a better valorisation of by-products and biogas.Thanks to the participation and exchange of personnel, the AD-WINE project partners will create an effective network of research and will collaborate in order to study this treatment system and develop a prototype. This will offer wineries an alternative to other current ways of treating water, offering countless environmental and economical advantages, and would allow the wine sector to comply with the legislation and the European objectives in terms of production of renewable energies. By participating in this project, the non-commercial research participants will have the opportunity to give a practical and commercial value to their research, whilst for the participating SME, it is the chance to gain knowledge on cutting edge technology and to develop innovative products, enhancing its growth and exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ERTMS on SATELLITE – Enabling Application  Validation' (2014-2020).

assistant: **Innovation**

The main ERSAT EAV objective  is to verify the suitability of EGNSS  (including EGNOS and Galileo early services) for safety railway application, in particular in regional lines scenario, for which a safe localization of the trains, based on satellite technologies, will be defined and developed, leading the way for the harmonization with the European ERTMS standard, by implementing the solution on a pilot line as reference.The objectives will be achieved, in a first phase by measuring and evaluating the gaps to be filled, in terms of technological criticalities and in relation to railway requirements, performing measurements under real operating conditions, building models and analysis with the help of the simulation, and finally defining and developing a system solution, implementing, testing and validating it on a  pilot line, as reference for the future standardisation and certification processes.The ERSAT EAV proposal is relevant to the work programme for the exploitation of the space infrastructure, in particular prioritising the EGNSS uptake for the rail sector, fostering the competition and the innovation of the European space and rail industry and research community, and  enhancing in parallel the strong coordination and synergy with the specific sector of European Railways and the main actors involved, building-up a system centered to the ERTMS platform and able to bring to the ERTMS the “competitivity-dividend” of the satellite promises,  linked with the enormous opportunity of the local and regional lines in Europe that represent about 50% of the total railways length. The EGNSS-ERTMS based train control/protection system is especially beneficial in terms of operating costs  compared to other solutions for upgrading the local/regional infrastructure, consider
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'New therapeutic targets for DM1: miRNAs analysis in DM1 disease models'.

assistant: **Objectives**

Expansion of a non-coding CTG tract in the DMPK gene leads to myotonic dystrophy type 1 (DM1), a dominant autosomal condition clinically characterized by myotonia, muscle waste and heart conduction defects among other symptoms. Transcripts containing long CUG stretches are toxic to the cell by their ability to interfere with gene expression regulation at several levels. Chief molecular alterations are sequestration of MBNL1 and upregulation of CUG-BP1, both alternative splicing regulators, leading to the expression of improper mature proteins. Additional molecular alterations have been suggested to contribute to the elaboration of the disease.We propose that changes in the normal levels of specific miRNAs entail a novel mechanism for DM1. This is supported by recent reports that found miR-206 misregulated in DM1 muscle tissue. Our long term objective is to identify additional miRNA expression alterations and to evaluate their potential as therapeutic targets. To this end, we will make use of two animal models, Drosophila and mice, both transcribing long CTG tracts. First, using complementary approaches of next generation sequencing and commercial real time PCR arrays we will obtain the miRNA expression profile in control and toxic RNA conditions. Second, we will characterize the origin of specific miRNA expression alterations, being suggested misregulated biogenesis, stability loss or direct sequestration by CUG RNA, and will validate the clinical relevance of our findings in DM1 muscle samples. Third, miRNAs relevant to DM1 will be functionally analyzed following loss and gain of function approaches in cell culture and in model animals. Finally, we will evaluate the suppression of toxic CUG RNA phenotypes in DM1 model flies in which expression of altered miRNAs has bee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Does hybridization facilitate explosive speciation of Lake Baikal amphipods?' in the context of a Horizon Europe call.

assistant: **Objectives**

The adaptive radiation of amphipods in Lake Baikal has brought forward more than 340 species (20% of the world’s freshwater amphipods), making it one of the largest species flocks after the famous African cichlid radiations, and one of the only large radiations in temperate climates. Despite this iconic status the radiation has not yet been subject to detailed genomic investigation. During my PhD I was able to demonstrate excessive amounts of parallel adaptation among the transcriptomes of species of this adaptive radiation. In this project, I will use genomic approaches to test whether the previous results could be explained by hybridisation and adaptive introgression. These processes have been shown to occur in other adaptive radiations, but their functional role in rapid diversification is still debated. My preliminary results indicate that hybridization between two independent lineages of Baikalian amphipods emerged in the period when fast speciation started. Furthermore, I found intriguing signals of positive selection on introgressed loci.Additional data and specific methodology developed in this project will enable me to disentangle the processes governing speciation in this group. Profiting from strong relevant experience of the host laboratory I will re-analyze available transcriptomic datasets together with newly sequenced genomes. I will map precise directions of hybridization at the phylogenetic tree, describe functional associations of introgressed loci, test selection signatures associated with introgression, and estimate the extent to which repeatable ecomorphological traits are underpinned by ""reusable"" elements of ancestral genomes. This research has groundbreaking potential in providing a direct test of a potential catalysing role of hybridization in