RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dissecting innate immunity to airborne opportunistic fungi through a genome-wide screen in Drosophila' (2007-2013).

assistant: **Innovation**

In recent years, airborne filamentous fungi have become major causes of life-threatening infections in an expanding population of severely immunocompromised individuals. Aspergillus remains the most common fungal pathogen in these patients, whereas Zygomycetes are emerging causes of fatal invasive fungal infections in many cancer institutions. Overall, the increasing frequency and spectrum of invasive fungal infections and the alarming rates of resistance to antifungal agents in fungi underscores the need to expand our knowledge on the immunopathogenesis of opportunistic fungal infections and develop novel therapeutic strategies. Importantly, the versatility of virulence mechanisms of fungi and the complexity of host defense mechanisms against fungi highlights the importance of understanding the molecular aspects of host-fungal interplay in robust experimental systems.Over the past decade, invertebrate mini-host models with well-characterized genetics and less complex immunity have been effectively used to explore several aspects of both fungal pathogenicity and antifungal host defense. These properties coupled with the robust genetics in Drosophila, make flies an ideal model to study the molecular aspects of host-fungal interaction.We have recently implemented Drosophila melanogaster as a model to study virulence mechanisms and the molecular aspects of host immune response to Zygomycetes. Surprisingly, we found that key aspects of the pathophysiology of zygomycosis in humans were appropriately modeled in fruit flies.In this proposal we expand on our previous work to:(a) Identify novel genes involved in Drosophila immunity against the most important airborne opportunistic fungi, Aspergillus and  Zygomycetes, by performing a genome-wide screening strategy in Drosophila R
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AcTafactors: Tumor Necrosis Factor-based immuno-cytokines with superior therapeutic indexes' (AcTafactors) targeting Horizon 2020.

assistant: **Abstract**

Tumor Necrosis Factor (TNF) is a homotrimeric pro-inflammatory cytokine that was originally discovered based on its extraordinary antitumor activity. However, its shock-inducing properties, causing hypotension, leukopenia and multiple organ failure, prevented its systemic use in cancer treatment. With this proof-of-concept study we want to evaluate a novel class of cell-targeted TNFs with strongly reduced systemic toxicities (AcTafactors). In these engineered immuno-cytokines, single-chain TNFs that harbor mutations to reduce the affinity for its receptor(s) are fused to a cell- specific targeting domain. Whilst almost no biological activity is observed on non-targeted cells, thus preventing systemic toxicity, avidity effects at the targeted cell membrane lead to recovery of over 90% of the TNF signaling activity. In this project we propose a lead optimization program to further improve the lead AcTafactors identified in the context of the ERC Advanced Grant project and to evaluate the resulting molecules for their ability to target the tumor (neo)vasculature in clinically relevant murine tumor models. The pre-clinical proof-of-concept we aim for represents a first step towards clinical development and ultimately potential market approval of an effective AcTafactor anti-cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PhD EuroConference Foundations of the Formal Sciences""', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Foundations of the Formal Sciences" is a series of interdisciplinary conferences in mathematics, philosophy, computer science and linguistics. The main goal is to re-establish the traditionally strong links between these areas of research that have been lost in the past decades. The talks of the conference will be addressed at a general audience, but their objective is to teach techniques and methods from the different parts of the Formal Sciences to researchers from other parts. The conference series began with FotFS I in Berlin (May 1999), which was a complete success. This conference managed to incite interdisciplinary joint work of the participants. We will publish refereed proceedings volumes for all conferences in the FotFS series. These volumes will not only serve as a reference for the conferences but are supposed to be reference works for future PhD students and people from other areas who want to learn the techniques from other parts of the Formal Sciences. The proceedings volume for FotFS I, edited by the coordinator of the present proposal and Florian Rudolph shows that this can be done with success.Its successor conferences FotFS II and FotFS III will be addressing applications of Mathematical Logic in other subfields of the Formal Sciences: FotFS II will be called "Applications of Mathematical Logic in Philosophy and Linguistics". We invited speakers from all parts of the Formal Sciences to give a holistic view of how mathematical methods can improve our philosophical and technical understanding of language and scientific discourse, ranging from the theoretical level up to applications in language recognition software. The topic of FotFS III will be "Complexity in Mathematics and Computer Science". Here the main focus is the understanding of the fact that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Breakthrough a glycyl radical enzyme long range activation mechanism' (GREAM), addressing dissemination and exploitation.

assistant: **Impact**

Glycyl radical enzymes (GREs) are one of the most prominent biological catalysts in both strict and facultative anaerobes. They are responsible for a broad range of radical-based chemistry and catalyse reactions involved in diverse metabolic pathways such as acid fermentation, DNA synthesis and the anaerobic metabolism of pollutants. GREs are activated by members of the S-adenosylmethionine (SAM) radical family. Activation of GREs requires the formation of a protein-protein activation complex with the small GRE-AE. All known structures of GREs show that a major conformational change very likely occurs during the glycyl radical generation upon interaction with the GRE-AE. Only a structure of a GRE:AE holocomplex would shed light on the unprecedented conformational changes involved in GRE activation. Glycyl radicals and iron-sulfur clusters are extremely oxygen sensitive, rendering the proteins challenging to work with.GREAM will narrow a significant knowledge gap by studying the anaerobic class III RNR natural fusion (NrdD:NrdG). In order to study the mechanism of activation, GREAM will use an integrative research approach combining biochemical, biophysical and cryo-EM – assisted by X-ray crystallography.With my experience in anaerobic protein characterisation and crystallisation, I will join the Fontecave lab to build up on their experience in spectroscopic characterisation of oxygen-sensitive protein complexes and achieve the first aim or GREAM. During a secondment in the Logan lab, who are expert in structural characterisation of aRNRs and have a long lasting collaboration with the host, I will solve the anaerobic cryo-EM structure of the NrdD:NrdG holocomplex and achieve the final goal of GREAM.  This newly established international collaboration will permit combinin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'BIODIVERSITY IN ALPINE FOREST ECOSYSTEMS : ANALYSIS, PROTECTION AND MANAGEMENT' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The project adresses biodiversity in terms of genetic diversity within and between carrier species of Alpine forest ecosystems. It will create a novel data pool in order to better understand the function and dynamics of ecosystems and to tansfer results into practice. By this, our project will also help to implement the Strasbourg/Rio/Helsinki process in conservation of biodiversity in forest ecosystems.Alpine forest ecosystems are increasingly threatened by environmental changes and are modified by forest management and land-use. Genetic diversity plays a major role in the sensitivity, stability and dynamics of ecosystems, because it determines the adaptive potential of species to changing environments. Until now there is a lack of genetic inventories in Alpine ecosystems. Our project focuses on significant tree species in high elevated regions, i. a. habitats with high priority in preservation. Species are Abies alba, Larix decidua, Picea abies, Pinus cembra, Pinus mugo. Species will be studied simultaneously along altitudinal transects up to the timberline at 15 locations throughout the Alps. Working packages:A: Sampling and monitoring: Assessment of diversity within species (inter- and interpopoulational) and among species by means of isoenzymes, DNA-markers and metric traits. Populations are adult stands, natural/artificial regeneration, provenance and other field trials, commercial reproductive material.B: Analysis and modelling: Quantification of biodiversity incl. metric traits and genetic resources; prediction of dynamics with respect to reproduction, response to stress, adapation and high risk situations followin enetic erosion and inbreeding.interdisciplinary characterization Of high elevated ec base forC: Validation and exploitation of results: Novel data os
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Efficient Synthetic Cell FDCA Production via an Integrated One-Pot Catalytic Process'.

assistant: **Concept**

SynCell aims to develop multicatalytic systems capable of performing multiple synthetic steps in sequence and under controlled conditions within a single process, reducing the need for external intervention and lowering environmental impact. Its primary objective is to emulate nature's ability to regulate macroscopic functions, by creating a ""one-pot"" method for synthesizing 2,5-furandicarboxylic acid (FDCA) from inexpensive and widely available sugars and polysaccharides.To achieve this, SynCell integrates various design principles into a unified system, utilizing Metal-Organic Frameworks (MOFs) as key components. MOFs provide distinct advantages, including high structural regularity, adjustable pore sizes, and uniform metal distribution. These features allow MOFs to act as multifunctional scaffolds, creating spatially distinct catalytic zones that enable complex, sequential reactions through compartmentalized catalytic sites. Additionally, Ionic Liquids (ILs) or Deep Eutectic Solvents (DES) can be employed as alternative media for effectively dissolving glucose (Glc) and polysaccharides. These solvents not only improve dissolution but also boost catalyst performance, creating a more efficient reaction environment.The combined use of multicatalytic MOFs with ILs or DES will result in a novel, environmentally friendly process for producing FDCA. This process, inspired by biological systems, enables the transformation of cheap, readily available sugars or polysaccharides without the need for intermediate purification or isolation.""


**Keywords:** Biorefinery,  2,5-Furandicarboxylic acid,  Metal-Organic Frameworks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Analysis of developmental expression pattern of xenopus laevis genes', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Two basic steps in the investigation of normal development are the identification of regulatory genes and the characterisation c their expression patterns, the latter being are a prerequisite for functional studies. Expression pattern of related genes in different vertebrate species have proven predictable power for other vertebrate species, including man, where gene expression analyses are not easily feasible. We propose to use Xenopus embryo as a vertebrate model system to systematically study gene expression. Our objectives are ? to carry out a molecular screen by in situ hybridisation in Xenopus embryos. documenting and characterizing the expression c 10 000 embryonal expressed mRNAs ? to tag sequence the corresponding cDNAs to match expression patterns to genes and identify genes wlth a potential function i growth control and differentiation ? to establish a Xenopus embryonic gene expression database and install it on the Internet Training content (objective, benefit and expected impact) The completion of this research project will train me in various fields. I will gain a general knowledge about development biology problematics and methods: anatomy, concepts on developmental processes... I count on having a more specific knowledge of the Xenopus model and of gene patterning in embryos. I expect that the analysis of the gene patterns will give new and important clues to understand some processes of normal development, in particular mesoderm regionalisation. The us of a vertebrate model of development is of particular interest due to its validity for human development, normal or pathologic The construction and management of the database will give me the opportunity to interact with bioinformatics scientists, and with researchers engaged in similar projects in other
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ELUCIDATION OF CRYSTALLISATION PROCESS USING FFF 3D PRINTER ASSISTED IR THERMAL IMAGING  TECHNIQUE ON  PLASTIC WASTE', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Nowadays, the issue of plastic recycling has become one of the major issues of environmental protection and waste management. Since 1950, humans have produced more than 8 billion tons of plastic, of which more than half was discarded into landfills and only 9% was recycled. The majority of plastic waste stemmed from semi-crystalline polymers such PE, PP and PET. When recycled, the properties of these polymers deteriorated due to shrinkage and warpage issues related to the crystallisation process that occurred during the cooling process. The temperature gradient during cooling is able to control the crystallisation growth. However, determining the crystallization process of plastic waste during processing is difficult as generally plastic waste contains additives. Therefore, CPW uses IR thermal imaging technique as it can capture the temperature profile of plastic waste during 3D printing to study the temperature-crystallisation relationship. The existing techniques, such as hot-stage microscopy, X-ray synchrotron and in-situ light scattering, have several restrictions. Among them are non-simultaneous processes, expensive, and requiring high energy radiation sources. Furthermore, these techniques can only be applied to virgin plastic and are limited to transparent polymers that are free from additives and contamination. The captured temperature profile will be analysed using MATLAB to examine the crystallite structure at precise temperature, thus could control their properties through the processing temperature of the 3D printer. An innovative approach through experimental setup and technique used to investigate the crystallisation process will be the novelty of CPW. This research will contribute to at least four research papers with two ISI journals and two conference p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigation of a fast acting boron injection system' (FABIS).

assistant: **Concept**

In the case of common cause failure of control rods, nuclear fission process in existing BWRs can't be stopped fast enough. This could cause a core melt accident. To avoid this, a fast acting boron injection system is proposed which stops the nuclear fission process during less than 30 seconds. This new system is passive like the scram system. The investigation of this system by different computer codes and by experimental test rigs shall confirm that this system can be cost-effectively added either to existing or to future BWRs and that a shutdown duration of less than 30 seconds can be realized.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Disruptive Treatment Control Software for Particle Therapy Centers' (C-TCS) under Horizon 2020.

assistant: **Objectives**

Cancer is one of the leading causes of death nowadays; 1 in every 2 men and 1 in every 3 women will be diagnosed with cancer at some point of their lives. The number of cancer incidences is growing by 2.4% annually, which puts a financial burden on healthcare systems globally. Particle therapy – PT (proton/neutron/positive ion therapy) has been proven to be effective and a safer alternative to other types of external beam radiotherapy as the charged particle dose is delivered in a narrow range and there is minimal damage to surrounding tissue. In 2015, among all patients that were treated for cancer worldwide, 25% were treated using some sort of radiation. However, building PT centres is very costly (>100M €) which has been a crucial factor in the slow adoption of PT facilities. This is likely to change due to introduction to lower cost/compact systems, and, more importantly, growing clinical evidence regarding its efficacy. A critical part of a PT centre is its treatment control system (TCS), the software that synchronizes the operation of all the devices. Currently, PT centre equipment vendors each custom develop their own TCS, which works only with their own equipment, is of limited configurability, closed to adjustments and expensive. Cosylab is a Slovenian company specializing in the field of control systems for particle accelerators with 17 years of experience in the field. We are developing our TCS (C-TCS) as an off-the-shelf product, that is universally usable on all vendors´ (integrators or manufacturers´) equipment. Our solution is easily configurable, available without lead times, and costing 3-5x-less than custom development. Overall, the C-TCS provides better cancer treatment efficacy, lower production and maintenance cost of PT facility, higher throughput
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mapping the population, careers, mobilities and impacts of advanced research degree graduates in the social sciences and humanities' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This proposal is focused on increasing our understanding of the career paths and employment patterns and contribution of doctoral graduates in the social sciences and humanities. The study focuses on three Objectives:Objective 1: Identification of the dimensions of the population and its core characteristics and assess trends in their employmentObjective 2: Identify the diversity of post-doctoral career paths in the SSH field.Objective 3: Assessment of the contribution that this diverse group of research-trained graduates make to Europe’s knowledge based economy and society (their ‘impact’).In order to respond effectively to these objectives a team of national experts has been put together. All the team have extensive experience of work in this area from a variety of disciplinary backgrounds and specific research skills. The team represents 13 European countries.  The national ‘reach’ of the team is however much broader with all participants having engaged in cross-country research spanning the EU and beyond.The work is distributed across 8 work packages combining a range of research review, policy analysis, statistical analysis with fresh survey research and qualitative interviews.The study incorporates an integrated impact strategy commencing at project start-up through close engagement with the stake holder and user communities and SSH researchers themselves. An active dissemination programme comprising text and web-based dissemination with 5 Regional Workshops and international quality level academic publication commitments.The results of this work will provide an important and entirely new evidence base enabling us to respond to the three objectives outlined above and shape the future of social sciences and humanities at European and National level.