RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'First Fully Integrated Drone System for Maritime Operations'.

assistant: **Concept**

With Upteko we want to revolutionize the maritime industry, by offering the first fully integrated drone system for ship operations.Unmanned Aerial Vehicles (UAVs), also known as drones, are increasingly impacting our everyday lives in several commercial sectors. Their potential in the maritime industry is huge, especially regarding security, environmental surveillance, reduce operational costs and monitoring. Drones can easily go where the humans cannot. However, their use in the sector is still at a very early stage. Drone technologies have emerged, but they are usually limited to single tasks and they face specific challenges as restricted fly duration and difficulty in operating in extreme weather conditions. These challenges prevent the maritime industry to fully benefit from UAV technology.Our company was founded in 2018 (origin in Creative Sight, founded in 2010) with the goal to take the lead in developing the next generation of drones for maritime operations. To achieve that, our highly skilled team (most experience drone team in Denmark) developed Upteko, an autonomous, multi-rotor UAV solution to meet the industry needs. Upteko is a holistic and fully autonomous combination of features, including high quality thermographic sensors and air pollution detector, for advanced ship inspection and data mining. The enhanced monitoring services our technology provides can result in 90% less damages for vessels. Able to prevent fire incidents through hot spot identification, our innovation can also reduce the human risk factor on a ships. Moreover, Upteko allows a 17% faster and safer harbor docking, early detection of pirate attacks (via visual data) and it constitutes a solid construction able to fly at winds of up to 70km/h.Upteko has attracted the attention of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Moduli of curves, sheaves, and K3 surfaces' (MCSK) under Seventh Framework.

assistant: **Objectives**

Algebraic geometry is the study of varieties -- the zero sets of polynomial equations in several variables. The subject has a central role in mathematics with connections to number theory, representation theory, and topology. Moduli questions in algebraic geometry concern the behavior of varieties as the coefficients of the defining polynomials vary. At the end of the 20th century several fundamental links between the algebraic geometry of moduli spaces and path integrals in quantum field theory were made. I propose to study the moduli spaces of curves, sheaves, and K3 surfaces. While these moduli problems have independent roots, striking new relationships between them have been found in the past decade. I will exploit the new perspectives to attack central questions concerning the algebra of tautological classes on the moduli spaces of curves, the structure of Gromov-Witten and Donaldson-Thomas invariants of 3-folds including correspondences and Virasoro constraints, the modular properties of the invariants of K3 surfaces, and the Noether-Lefschetz loci of the moduli of K3 surfaces.  The proposed approach to these questions uses a mix of new geometries and new techniques. The new geometries include the moduli spaces of stable quotients and stable pairs  introduced in the past few years. The new techniques involve a combination of virtual localization, degeneration, and descendent  methods together with new ideas from log geometry. The directions discussed here  are fundamental to the understanding of moduli spaces in mathematics and their interplay with topology,string theory, and classical algebraic geometry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Arithmetic of algebraic surfaces' in the context of a Seventh Framework call.

assistant: **Objectives**

This research proposal concerns a fundamental problem in the theory of al-gebraic surfaces which poses one of the most important challenges in order tounderstand the inner structure of algebraic surfaces beyond the current state ofthe art. Our research team will investigate in detail the structure of curves onalgebraic surfaces which is captured in the Neron-Severi group. In general, itis a widely open problem to decide which shapes this group can take. By de-signing innovative and unconventional approaches at the borderline of arithmeticand geometry, we aim at groundbreaking results that will spark deep insightsinto the inner structures of algebraic surfaces and lay cornerstones for futureinvestigations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Predicting individual response and resistance to VEGFR/mTOR pathway therapeutic intervention using biomarkers discovered through tumour functional genomics'.

assistant: **Innovation**

The strategic development of accurate biomarkers to predict response to therapy in cancer medicine will enhance clinical outcome and reduce the health economic impact of drug resistant disease. The PREDICT consortium will identify and validate predictive biomarkers for two drugs which have direct anti-tumour cell and anti-angiogenic activity and for which no established predictive biomarkers of tumour response exist: sunitinib, a multi-targeted tyrosine kinase inhibitor, and everolimus, an mTOR pathway inhibitor. Renal cell carcinoma (RCC), a disease sensitive to these agents, will serve as the model tumour type to identify predictive response biomarkers suitable for widespread application across diverse tumour types. PREDICT’s biomarker discovery approach is based on the integration of genomics data from pre-operative RCC therapeutic clinical trials with novel personalised functional genomic screen datasets. We will systematically collect tumour tissue from monotherapy pre-operative window RCC clinical trials of 240 patients treated with everolimus or sunitinib and determine expression profiles, copy number aberrations, and genome-wide exon sequences of tumours before and after drug treatment. We will perform two types of RNA interference drug- and hypoxia-resistance screens: one using reverse transfection of commercial siRNA libraries into previously established RCC cell lines, and one using a novel approach through personalised tumour cDNA derived-shRNA library transduction of ex-vivo cultured autologous tumour cell lines. Bioinformatics integration of these complementary individualised clinical and experimental datasets will enable the rapid and cost efficient identification of predictive biomarkers and simultaneously define molecular mechanisms contributing to intr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'THERAPEUTIC EPIGENETIC ENHANCEMENT OF THE INNATE IMMUNITY TO EFFECTIVELY  COMBAT ANTIMICROBIAL RESISTANCE [IN-ARMOR]' in the context of a Horizon Europe call.

assistant: **Objectives**

Antimicrobial resistance (AMR) & multi-drug resistance, whereby pathogens evolve to resist antibiotic drugs, is designated by WHO one of the top 10 health threats of our time and is a top 3 priority health threat requiring EU level coordination. AMR was estimated to be linked to 4.95 million deaths in 2019. The next global pandemic could be a multi-drug resistant bacterium, or emergence of ‘pan-drug’ resistant strains (resistant to all existing drugs). Alternative therapeutic approaches are proving to be expensive and slow to develop, whilst also facing the risk of evolving strains. The innate immunity presents the strongest potential to tackle AMR as it can generate antimicrobial molecules and proteins that directly inhibit microbial survival. Inducing such proteins has shown effective antimicrobial activity against bacteria, viruses, fungi & protozoa. Building on this approach, leading professors and researchers from 9 Universities and research institutes are collaborating with 7 medical and industry partners representing 9 EU countries to introduce a novel class of immune system inducers able to enhance the body’s own innate microbial defence mechanisms to combat AMR and reduce incidence of the 13 listed most dangerous infections (including 2 of the top 3 priority-1 infections).IN-ARMOR will optimise an already developed drug platform using Computer Aided Drug Design, and in-silico approaches, in tandem with a nanotech-based drug delivery system for the first target indication. The developed therapy will be pre-clinically validated for safety and efficacy in-vitro and in vivo to complete all investigational Medicinal Product requirements.Upon completion, IN-ARMOR will be prepared for clinical validation. Upon commercialisation, IN-AMOR could potentially save more 4Mn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EuroNanoForum 2013 Nanotechnology Innovation: From research to commercialisation – the bridge to Horizon2020' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The EuroNanoForum 2013 Nanotechnology Innovation: From research to commercialisation – the bridge to Horizon2020 conference is proposed to be held in Dublin during the Irish presidency of the European Union. It will be organised by Enterprise Ireland, the Government organisation responsible for the development and growth of Irish enterprises in world markets. The conference will be held from June 18th to June 20th 2013. The first 2 days of the conference will feature plenary sessions, presentations, workshops and several accompanying activities which will be used to explore the scientific, industrial and societal issues targeted by the conference. A third day will be used to foster networking at the various levels using industrial and research centre visits, a brokerage event and an investor’s forum.The main focus of the conference will be the commercialisation of nanotechnology, exploiting its potential for new applications, pushing it from an enabling technology through to development and on to end product use.With Horizon2020 and its new structure beginning in 2014 the conference will be used to look at how nanotechnologies will fit into the targeted key priority areas of Excellent Science, Industrial Leadership and Societal Challenges.ENF2013 will be part of the official Irish EU presidential calendar hosted by the Office of Science and Technology of the Department of Jobs Enterprise and Innovation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Theory of Memory Causation' (MEMOCAUSE).

assistant: **Innovation**

On the causal theory of memory, remembering an event requires a causal connection to a past experience. I can remember my last birthday because I have experienced it before. On the simulation theory, in contrast, remembering a past event is very much like imagining a future one: in both cases, a causal connection to a first-hand experience of the event is not necessary. The debate between causalists and simulationists has been at center stage in the thriving new field of philosophy of memory. Despite this, there has been no systematic analysis of the notion of causation relevant to memory. As a result, the nature of memory causation has remained largely unexplored.This project aims to fill this significant lacuna. It will develop the first comprehensive theory of memory causation, bringing together results from the philosophy of causation and the interdisciplinary study of memory. It will aim to clarify what it means to say that memories are caused by past experiences and to establish whether such causation is necessary. The project's core thesis is that claims about memory causation should be relativized to causal models — mathematical models that represent the functional relationships between variables in a system. A memory is caused by a past experience iff, relative to an appropriate model of the memory system, it is counterfactually dependent on it, but only in precisely defined contexts. If all memories are so dependent, then causation is necessary for remembering. With a proper formulation, the causal necessity thesis can be assessed. The working hypothesis is that the thesis faces substantial difficulties and is likely false. Hence, causal theories fail and the simulationist rejection of the necessity of appropriate causation is warranted. The project will make
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Designing Human-centered Sustainable Cyber-physical Systems of the Future' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This proposal presents the research idea of an experienced researcher (ER), Didem Gürdür Broo, which is called “Designing Human-centered Sustainable Cyber-physical Systems of the Future” (Sustainable-CPS). The project is designed as a research training fellowship between KTH, Royal Institute of Technology (beneficiary for m1-m12), Uppsala University (beneficiary for m13-m24) located in Sweden and Stanford University (partner organization) located in the United States of America. Didem Gürdür Broo invited to work in Professor Leifer’s designX research lab at Stanford University. ER wants to initially work with the research group at Stanford for a year to develop a framework through small case studies and observations and then come back to Sweden to introduce and evaluate the framework through workshops. Today, CPS exist everywhere in different sizes, with different functionalities and capabilities. Some examples can be listed as smart cities, industry 4.0 applications, internet of things, autonomous systems, intelligent transport systems and so on. Several characteristics of these systems are new and these new properties push the limits of traditional engineering practices. Some examples of these new characteristics are intelligence, autonomy, connectivity, and collaboration. Moreover, today’s engineering education and practices are preliminarily concentrating to solve technical problems related to these systems and, unfortunately, do not include sustainability and social implications perspective as default.  Sustainable-CPS project aims to use interactive, collaborative, and innovative tools from design thinking, systems thinking and future studies to develop a framework and a toolkit to support the design of future CPS by primarily focusing on human needs, social impli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Onboard treatment of Ballast water (technologies development and applications) and application of low-sulphur marine fuel' (MARTOB), addressing dissemination and exploitation.

assistant: **Impact**

The objectives of the proposed research are:(1) to investigate methodologies for preventing the introduction of non indigenous species through ships' ballast water;(2) to develop design tools and treatment equipment to be used in the further development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Support for a European Workshop on Individual Monitoring of External Radiation'.

assistant: **Innovation**

The Workshop assesses the present status of individual monitoring procedures and requirements for external radiation within the EU Member States and within Europe.The Workshop will review current research programmes and recent developments in individual monitoring. General objective is to contribute to the implementation of the Council Directive 96/29/Euratom. The aim of the present accompanying measures proposal is to obtain support for the travel and subsistence costs of the invited speakers and for arranging the meetings of the scientific and programme committees, to support to the local administration and to cover the expenditures of publication of the proceedings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Revolutionising Downstream Processing of Monoclonal Antibodies by Continuous Template-Assisted Membrane Crystallization' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Separation and purification of biopharmaceuticals is today one of the most time and cost intense Downstream Processing (DSP) operations in the manufacture of commercial products. Separation and purification of proteins is usually achieved chromatographically, with all of its disadvantages including high buffer requirements, large footprint, reuse and storage of resin studies as well as costs. Traditional DSP based on batch chromatography contribute ca. 66% of the total production cost of anti-cancer monoclonal antibodies (mAbs). Largely contributing to this is the cost of chromatography media; for instance, the cost of 1 L of protein A resin with binding capacity of 20-70 g mAb is about 25000 Eur. By a visionary and ambitious combination of the emerging Continuous Manufacturing Paradigm with innovative Membrane Crystallization Technology and the selective nanotemplate-recognitions directly from the fermentation broth, the AMECRYS Network aims to develop a new Continuous Template-Assisted Membrane Crystallizer in order to revolutionize the DSP platform for mAbs production, thus achieving unprecedented purification and manufacturing efficiencies. Major research challenges will include: i) the synthesis of 3D-nanotemplates with specific molecular recognition ability towards mAbs from complex solutions; ii) the development of tailored macroporous fluoropolymer membranes for advanced control of selective heterogeneous nucleation; iii) the design of multilevel microfluidic devices for high-throughput mAb crystallization screening in a wide range of conditions under continuous flow (“pharma-on-a-chip” concept); iv) technology scale-up to a L-scale continuous prototype designed with recognition of QS/GMP compliance for biopharmaceuticals. The replacement of chromatography with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Industry 4.0 for SMEs - Smart Manufacturing and Logistics for SMEs in an X-to-order and Mass Customization Environment' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Industry 4.0 refers to the fourth industrial revolution and technological evolution from embedded systems to cyber-physical systems (CPS) in production. The main objectives of Industry 4.0 can be summarized as the introduction of intelligent systems in production and logistics, the development of highly adaptable and modular manufacturing and logistics systems, the integration of sustainable and advanced manufacturing technologies as well as the promotion of automation technology and human-machine interaction. In the context of Industry 4.0 new ICT and web technologies act as booster or enabler of smart, autonomous and self-learning factories facing the challenges of even more individualized and customized product portfolio.A great challenge for the future lies in the transfer of Industry 4.0 expertise and technologies in small and medium sized enterprises (SME). SMEs represent the backbone of the economy and have an enormous importance in the development programs of the European Union for strengthening the competitiveness of European enterprises. Although the high potential of Industry 4.0 in SMEs, the main limit lies in a lack of concrete models for its implementation and application in small and medium enterprises. Thus, this research project titled “Industry 4.0 for SMEs - Smart Manufacturing and Logistics for SMEs in an X-to-order and Mass Customization Environment” aims to close and overcome this gap through the creation of an international and interdisciplinary research network. Identifying the needs and enablers for a smart and intelligent SME-Factory, creating adapted concepts and design solutions for production and logistics systems in SMEs and developing suitable organisation and business models will be the three main objectives of this research network. The