RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PERtussIS COrrelates of Protection Europe - Sofia ref.: 115910' in the context of a Horizon 2020 call.

assistant: **Objectives**

Pertussis vaccines have been very successful in reducing the global burden of pertussis-related disease. However, in the last decade there has been a rise in pertussis incidence, particularly in vaccinated adolescents and adults in industrialized countries. The increased circulation of B. pertussis (Bp) constitutes a risk for transmission to vulnerable infants and older adults. Additionally, immunity in humans has been shown to wane rapidly after immunization with pertussis vaccines, especially with acellular pertussis (aP) vaccines, suggesting that the improved reactogenicity profile of aP compared to whole cell pertussis vaccines, may be accompanied by differences in duration of immunity. The key objectives of PERISCOPE are to 1. identify biomarkers of protection against Bp colonization and disease 2. foster scientific innovation and rebuild the ecosystem and technical infrastructure needed in Europe to allow the future evaluation of novel pertussis vaccine candidates and 3. improve understanding of the pathogenesis of Bp infection and its potential impact on the recently observed changes in pertussis epidemiology. To reach these objectives, PERISCOPE brings together a selected group of internationally recognized public and EFPIA partners with strong expertise in clinical trials, immunology, molecular microbiology, human and animal challenge models and bioinformatics. We will initiate a series of (pre)clinical studies and develop harmonized human and animal challenge models, standardized assays and cutting-edge techniques to unravel the innate and adaptive responses to Bp. This will allow us to identify biomarkers of protection and durable immunity. PERISCOPE will thus facilitate the accelerated development and registration of novel pertussis vaccines and/or guide opt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plasmasphere Ionosphere Thermosphere Integrated Research Environment and Access services: a Network of Research Facilities' (PITHIA-NRF) under Horizon 2020.

assistant: **Objectives**

PITHIA-NRF aims at building a European distributed network that integrates observing facilities, data processing tools and prediction models dedicated to ionosphere, thermosphere and plasmasphere research. For the first time, PITHIA-NRF integrates on a European scale, and opens up, to all European researchers, key national and regional research infrastructures such as EISCAT, LOFAR, Ionosondes and Digisondes, GNSS receivers, Doppler sounding systems, riometers, and VLF receivers, ensuring optimal use and joint development. PITHIA-NRF is designed to provide organized access to experimental facilities, FAIR data, standardized data products, training and innovation services. Furthermore, PITHIA-NRF facilitates drastically research advances in the field of upper atmosphere and near-Earth space, through the integration of data collections from satellite missions (such as Cluster, DEMETER, Swarm and CHAMP) and results from key prediction models (such as IPIM-IRAP, MCM-SWAMI, SWIF and EUHFORIA) that can be accessed by scientific users for join exploitation with the data collected from the research infrastructures of the network. PITHIA-NRF paves the way for new observing technologies, and to standard-making processes for software and high-level data products that are tuned to meet the requirements of technologies concerned, linking best-in-class R&D facilities to provide seamless multi-technology services.


**Keywords:** Ionosphere; Thermosphere; Plasmasphere; Incoherent Scatter Radar; Ionosonde; Digisonde; GNSS receivers; upper atmosphere climatology, space weather variability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'GALATEO (Good Attitudes for Life in Assyrian Times: Etiquette and Observance of Norms in Male and Female Groups)' (GALATEO).

assistant: **Concept**

The GALATEO (Good Attitudes for Life in Assyrian Times: Etiquette and Observance of Norms in Male and Female Groups) project aims to understand anew the importance of etiquette in late Assyrian society (10th–7th century BCE) and to investigate through a multidisciplinary approach the extent to which etiquette influenced the subsequent cultures of the Middle East. As a showcase of the project, the creation of an open source Atlas will be delivered, which is conceived as an open repository, in which the addition of new references to delineate the manners of a given culture can contribute to the understanding of etiquette, from the ancient to the modern Middle East. GALATEO develops and works through an adaptable sociological and anthropological theoretical model for the study of etiquette in the ancient Middle East. To this end, the sociological perspective will explore the way that correct behaviour in Assyrian society was codified and imposed during meetings, both religious and lay, in variously political, economic, and convivial settings. In this way it will be investigated how etiquette becomes a means for both men and women to display their social status and gender balance. The anthropological perspective will examine the etiquette of hygiene, especially concerning the practices of proper handwashing, body washing, facial cleanliness, and bodily purification from a religious point of view, the intention of which was to avoid the transmission of disease, such as sex and bodily pollutions, as well as the admission of evil spirits. This analysis will show how the extent to which hygiene plays a role in assigning order and integrity to a culture or group. Being adaptable, this model will pave the way for emerging new perspectives on understanding the social history of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nanostructural surface development for dental implant manufacturing', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The project NanoSurf is targeted to strengthen international and intersectoral collaboration in dental implant research, sharing new ideas and knowledge transfer from research to market and vice versa. We will investigate nanostructured metal oxide coatings, 3D scaffolds, obtained by electrospinning deposition of organic nanofibers and lazer patterning of the implant surface using biotechnology, cell engineering and nanotechnology. Interdisciplinary project research and innovation goals are targeted to develop a new class of dental implants with advanced mechanical properties and improved surfaces, treated with nanotechnological methods which will demonstrate high biocompatibility, antibacterial properties and integration with a patient’s bone. The developed devices will simplify dental surgery and avoid bacterial inflammatory complications after the implant surgery. This can provide better dental services and improve health of EU society.  The project partners will provide research and training activities in the fields of fabrication and characterization of Zirconium-Titanium (ZrTi) alloy-based dental implants, sol-gel deposition of metal oxides, biopolymers and organic/inorganic nanolaminates, laser patterning, electrospinning, structural characterization, cell engineering, modeling analysis and commercialisation of scientific achievements from research results to final product.Research and management training will be provided to experienced and early stage researchers to strengthen their personal skills, improve their track record and expertise via new scientific papers and conference presentations and strengthen a development of EU research human resources. Long lasting collaboration between partners, based on co-supervising students and preparation of novel collabo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'iABC Programme' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cystic Fibrosis (CF) is a common fatal inherited disease with a frequency of 1 in 2500 live births, affecting approximately 36,000 (0.737/10,000) people in the EU. Chronic bacterial pulmonary infection leading to an irreversible decline in lung structure and function is the main cause of mortality and morbidity in patients with CF, with more than 95% of deaths due to respiratory failure. Pseudomonas aeruginosa (Pa) is the most frequently isolated pathogen, chronically infecting up to 80% of adult patients. When this occurs patients require lifelong inhaled antibiotic therapy, which although onerous to take, has been fundamental in increasing life expectancy by suppressing infection, reducing exacerbations and preserving lung function in CF patients chronically infected with Pa. Studies employing enhanced culture techniques and culture-independent molecular approaches have recently shown that the lungs of CF patients harbour diverse polymicrobial communities, the “microbiome”. Other Gram-negative non-fermenting bacteria (GNnF), including Stenotrophomonas maltophilia and bacteria from the genera Burkholderia, Achromobacter, Acinetobacter, Ralstonia and Pandoraea may be present and contribute to disease. Moreover, Burkholderia cenocepacia is associated with rapid deterioration of lung function and poor clinical outcome.  Estimates for the prevalence of non-CF bronchiectasis (BE) range from 4 per 100 000 in young adults to nearly 300 per 100,000 in persons 75 years and older in developed countries. The number of adults is increasing significantly and the forecast is that the number of adults with CF will increase by 100% between 2010 and 2025. These individuals will mostly have chronic infection with Pa. Individuals with BE have chronic cough and sputum production and frequ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Biotechnological conversion of carbon containing wastes for eco-efficient production of high added value products' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The applicants propose the development of a sound industrial process that unites the urgently needed solution of industrial waste problems with the creation of essential alternative strategies for polymer industry. This will be done by the biotechnological conversion of waste streams from slaughterhouses, rendering and biodiesel industry towards biodegradable polymeric materials. Slaughterhouse waste is converted towards fatty acid esters (FAMEs, biodiesel). Subsequently those FAME fractions that negatively influence the biodiesel properties as a fuel are biotechnologically converted towards high-value polyhydroxyalkanoate (PHA) biopolymers. This brings together representatives of the envisaged lead users: waste producers from animal processing industry and bio-fuel industry with the polymer industry looking for alternatives technologies. Providing long-term strategies for long-term problems, the project will result in value creation for all players and provide innovative biotechnological approaches for absolutely needed eco-efficient alternatives to contemporary industrial polymer production. The development of this integrated process will be accomplished by beyond the state-of–the-art inputs of microbiology, genetics, biotechnology, chemical engineering, polymer chemistry- and processing and life cycle analysis, combined with feasibility studies for marketing of the final products. The compiled Consortium absolutely conforms to the requirements to fulfill the envisaged project aims. Research will be done in close cooperation between academic and industrial partners. The project activities aim at solving local waste problems affecting the entire EU; the solutions will be developed on local scales, but are meant to be applied to the entire EU and will provide cost-effic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural Analysis of Mathematical Proofs' (STRUCTPROOFS), addressing dissemination and exploitation.

assistant: **Impact**

Proof Theory is the branch of mathematical logic that investigates formal proof systems modelling mathematical reasoning. There are different types of proof systems, each having its own advantages and disadvantages. A certain class of proof systems (Gentzen-type systems) has the interesting property of exhibiting a geometric structure in proofs. Logical and proof-theoretic problems that are formulated in the context of these systems are thus susceptible to analysis by geometric and combinatorial methods. The recent years have seen a development of a great variety of such methods by different communities. The aim of the proposed project is the application of these geometric and combinatorial techniques to logical problems in proof theory. The proof-theoretic problems have been carefully selected in order to lend themselves well to the analysis by these methods. The scientific impact of this project will be twofold: On the one hand, the solutions of the problems will be of importance for proof theory and the foundations of mathematics in their own right. On the other hand, the combined application of combinatorial methods from different traditions will have a unifying effect on them, leading towards a general theory of proofs as combinatorial structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Certification and human error considerations - knowledge propogation into new safety critical technologies' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

In Transport and other Safety Critical Technologies 60-80% of accidents have Human Error as a major factor. However, there are no agreed minimum standards for considering the vulnerabilities to human error in these systems. In the Aerospace domain, Regulatory Authorities and Industry have joined forces to evaluate the certification process. An FAA/JAA Harmonization Working Group (HWG) will propose new ways of addressing the vulnerabilities of a design to human error in this process. CHECKPOINT will participate in the HWG to promulgate the results of European research projects and involve stakeholders in the process. CHECKPOINT will influence the rulemaking process, prepare industry for compliance and disseminate lessons learned to other safety critical domains. It will ideally position the EC for the preparation of future R&D and policymaking activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'INternational Smart Collaborative Open-access hybrid Printed Electronics pilot line' (InSCOPE), addressing dissemination and exploitation.

assistant: **Impact**

The InSCOPE project will set-up an open access pilot line service for Hybrid TOLAE (H-TOLAE) technologies capable of sampling products at TRL6-7. It positions itself in between R&D and industry and deploys a service for validating potential H-TOLAE products. Manufacturing progresses beyond R&D level (TRL5 towards 6) by improving processes, functionality and reliability allowing sampling at high quality and in relevant numbers needed for industrial qualification (TRL 6-7). The applications addressed cover automotive, healthcare, smart packaging and buildings. After InSCOPE, the Pilot line service will remain accessible to interested parties. The pilot line is serviced by top European RTD’s with leading technological positions and state of the art equipment in the domain of H-TOLAE.InSCOPE will set up an open access pilot line infrastructure for H-TOLAE technology, which is modular ensuring a comprehensive toolbox of printing, assembly, production integration and process validation distributed over the partners. InSCOPE will ensure interoperability between the differing modules at the partners enabling end-users to combine different processes step from different partners in their process flow. It will accelerate the uptake of H-TOLAE technology by delivering a public handbook describing functionalities, production guidelines and design rules of H-TOLAE, including new opportunities for “traditional” electronics. Validation of the pilot line service by 4 Showcases and 15 development cases are included within the project. The Showcases consist of H-TOLAE product prototypes at TRL 5 to be matured on functionality and on manufacturability. The showcases will steer the pilot line improvement. They are selected based on their economic impact as well as the technological status o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improvement of enzyme operational stability in low-water systems' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content Mechanisms affecting the operational stability of enzymes in low-water environment will be analysed, with specific reference to enzymatic systems of potential, industrial interest. New experimental procedures will be developed to study the influence of each mechanisms. In particular, dehydration phenomena will be studied on immobilised samples of enzyme in a continuous, low-water reactor. A new experimental procedure will be followed, based on a modified 0-18 labelling technique. Moreover, covalent changes in the enzyme molecules will be detected by electrospray mass spectrometry. The influence of intermolecular reactions between proteins, as well as the effect of covalent oxidative processes, will be studied through specific tests. An original approach will be developed to analyse conformational changes on low-water enzymes: proteins will be immobilised on the outside surface of an optical fibre. Fluorescence and adsorption properties could be studied from the inside. Packed beds will be used as experimental reactors. They will be run in differential mode, in order to expose the biocatalyst to constant operating conditions. Different reactor configurations (single reactor, reactors in series or in parallel) will be tested in order to monitor accurately catalyst activity, as well as to prevent experimental problems. Experimental approaches will be developed to obtain biocatalytic nonaqueous systems offering good performance in terms of catalytic activity, long-term stability and product yield. To this respect, several immobilisation methods and molecular imprinting techniques will be tested. Training content (objective, benefit and expected impact) The researcher will acquire a wider competence in a scientific area of high industrial inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Animals models for breast tumor formation'.

assistant: **Innovation**

Breast cancer is the most common malignancy in women and a high level of mortality, associated with this cancer, still remains. To eradicate tumour progression and/or metastatic development, cancer cells need to be targeted directly by treatments, which may not be the case with current therapeutical drugs.By high-throughput screening of breast tumour from treatment resistant patients, the laboratory has identified several discriminator genes encoding transcription factors and proteins associated with cell division. The objectives of the project is first to generate animal models to determine in vivo how over-expression of these genes can induce tumour growth and/or are responsible for generating cells resistant to treatment.These animal models will allow in a second part, to determine and test therapeutic tools. The use of animal models, associated with new technologies of microarrays and imaging will allow to identify the genetic or cellular regulations responsible for tumour generation and spreading and will permit to establish adapted treatments or new therapeutic tools.