RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Characterizing the fitness landscape on population and global scales'.

assistant: **Objectives**

The fitness landscape, the representation of how the genotype manifests at the phenotypic (fitness) levels, may be among the most useful concepts in biology with impact on diverse fields, including quantitative genetics, emergence of pathogen resistance, synthetic biology and protein engineering. While progress in characterizing fitness landscapes has been made, three directions of research in the field remain virtually unexplored: the nature of the genotype to phenotype of standing variation (variation found in a natural population), the shape of the fitness landscape encompassing many genotypes and the modelling of complex genetic interactions in protein sequences. The current proposal is designed to advance the study of fitness landscapes in these three directions using large-scale genomic experiments and experimental data from a model protein and theoretical work. The study of the fitness landscape of standing variation is aimed at the resolution of an outstanding question in quantitative genetics: the extent to which epistasis, non-additive genetic interactions, is shaping the phenotype. The second aim of characterizing the global fitness landscape will give us an understanding of how evolution proceeds along long evolutionary timescales, which can be directly applied to protein engineering and synthetic biology for the design of novel phenotypes. Finally, the third aim of modelling complex interactions will improve our ability to predict phenotypes from genotypes, such as the prediction of human disease mutations. In summary, the proposed study presents an opportunity to provide a unifying understanding of how phenotypes are shaped through genetic interactions. The consolidation of our empirical and theoretical work on different scales of the genotype to phenotype
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Photoactivatable platinum - iv - anticancer complexes - advanced nmr studies of dna-binding and redox reactions' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content The aim of this project is the further development of photoactivatable Pt(IV)-prodrugs for the treatment of cancer. To achieve this, it is critical that the pathways and reactive intermediates of the photoreactions and the structures of the final photolysis products be known in detail. For these investigations, (1H, 15N) NMR HSQC methods will be employed to study the photochemistry of photosensitive Pt(IV)-complexes. By using 5N-labeled Pt(IV)-complexes, the identity of the primary photolysis products in the presence and absence of single-and double-stranded GG oligonucleotides will be investigated. This will clarify the role of the nucleotide bases in the photochemical reactions. An important goal of this project will be to determine whether the DNA-platinum adducts resulting from the photolysis products are structurally similar to those caused by the clinical-used platinum-based chemotherapeutic agent, cisplatin. Another objective of this project will be to investigate by means of NMR the mechanism of reaction of selected Pt(IV)-complexes with other biomolecules such as glutathione and proteins (e.g. albumin), and to determine the effects of light on these reactions. Whether photoactivated Pt-species induce protein-DNA cross-linking reactions will also be investigated. A knowledge of the details concerning the photochemistry of Pt(IV)-complexes will allow us to improve the design of light-activatable Pt(IV)-prodrugs, which could lead to more effective, less toxic therapies of cancer. Training content (objective, benefit and expected impact) This postdoctoral fellowship will allow me to learn and practice state-of-the-art NMR techniques in one of the world's most renowned NMR groups. I will also benefit from the expert knowledge of Pro?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'L'ingenieur, un médiateur entre le monde de la recherche et la société: un modèle européen?' (ENQHEEI), addressing dissemination and exploitation.

assistant: **Impact**

Ce projet vise a fournir un éclairage sur la formation en Europe des futurs ingénieurs et scientifiques, acteurs de l' innovation. Cette première analyse porte sur les profils d'ingénieurs et scientifiques, les modes de formation, les centres de recherche et d'innovation couples, et sur la thématique particulière du Développement durable ; elle a pour but : de faire émerger des pratiques de formation a l'innovation renforçant les objectifs et les réalisations de l'EER ;de les diffuser, via un réseau expérimental européen de la Qualité de la Formation des Ingénieurs, sur 6 pays (D,E,FIN,F,I,S); de comparer ces pratiques et leurs résultats entre elles et avec celles d'autres pays (USA) ; de préparer la mise en oeuvre du 6ème PCRD en pointant les domaines et actions pouvant être privilégiés au regard de la formation, ainsi que les outils et méthodes d' observation et de diffusion des bonnes pratiques pouvant être durablement installés.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sub-Nanoscale Observation of Magnetic Monopole Noise' under Horizon Europe.

assistant: **Concept**

The magnetic version of the electron, the Dirac magnetic monopole, although predicted to exist, has yet to be discovered. Recently, the search for emergent magnetic monopoles in quantum materials has focused on spin-ice compounds, which host magnetic monopoles as emergent quasiparticles. Even though emergent monopoles have been studied using the toolbox of quantum matter research, the long awaited monopole detection is still lacking because of the limited low spatial resolution probes and temperature range of the experiments. In this proposal, I present a plan to develop a novel concept called Scanned Spin-Noise Microscope (SSNM) and provide a cutting-edge instrument for realising a Sub-Nanoscale Observation of MAgnetic monopole Noise (SNOMAN). The SSNM will be designed to operate in a cryogen-free dilution refrigerator to slow down the monopole dynamics and realise the long-awaited single monopole detection. I aim to undertake this project under the supervision of Prof. Seamus Davis at University College Cork, where all the necessary facilities and expertise are available to achieve the objectives described in this proposal.


**Keywords:** Magnetic Monopole, Magnetic noise, Scanning experiment, SQUID, Low temperature, permalloy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Real-world emission Experiments and comprehensive Assessment of Low-carbon fuels: towards Clean Hard-to-Electrify traffic Modes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The REALCHEM project aims to promote a clean and climate-friendly transport system by studying emissions from low carbon fuels in hard-to-electrify (HtE) transport sectors, including aviation, shipping, and heavy-duty on-road and non-road mobile machinery. The project will observe emissions from various fuels and engines under real-life conditions, model their effects on air quality and human health, and focus on the most important new technologies. REALCHEM will use a large amount of pre-existing data on both low-carbon and fossil fuels, and conduct novel experimental work in all three HtE transport modes. The aim is to produce guidance and technology packages for cleaner transport in terms of health effects and climate impacts. The data will be organized into a low-carbon fuel emission database, which will help REALCHEM generate new knowledge and identify the most efficient new fuels and technologies. The project has three main objectives: 1) Produce robust, comprehensive, and actionable scientific data on the characteristics of emissions from low-carbon fuels in the Hard-to-Electrify transport modes. 2) Understand the effect of introducing low-carbon fuels to the developing technology matrix on human health, climate, and the environment: 3) Help technology developers and users to understand the emission formation and reduce the harmful pollution from engines using low-carbon fuels.These efforts are in line with Europe's ambitious climate targets, the Green Deal, and the vision of zero pollution by 2050. The need for combustion-based technologies in heavy-duty transport, non-road machinery, shipping, and aviation sectors remains, and the decarbonisation of these sectors is expected to be driven by a shift from fossil fuels to low-carbon alternatives. This will lead to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'LIGHTWIND: A DISRUPTIVE DRIVE-TRAIN FOR ULTRALIGHT AND LOWER COST WIND TURBINES' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The current drive-train solutions for bottom-fixed offshore wind turbines do not necessarily work well for floating wind turbines, especially when it comes to increasing the size of the turbines beyond the current state of the art. The increasing nacelle weight makes it difficult to develop floating platforms that are both technically and economically viable beyond 15 MW. Also, high repair costs of current drive-train solutions are making sites far off coast (which would be technically viable for floating wind turbines) economically unacceptable. Innovation is needed to develop new solutions for floating wind turbines that can reduce the weight of nacelle and rotor and subsequently also of the supporting structures, while maintaining or increasing energy production and decreasing repair costs.This project proposes to develop a disruptive, compact and lightweight drive-train solution, that offers significant advantages in terms of mass, turbine and repair costs, scalability, critical materials usage, and social and environmental impacts.The LIGHTWIND project aims at demonstrating the technical feasibility of the concept and at evaluating the economic, social, and environmental benefits by comparing it to existing 15 MW turbine reference models. Additionally, the project will demonstrate that these benefits allow the scaling of floating offshore wind turbines to 22 and 30 MW.


**Keywords:** wind energy, floating offshore wind, drive-train, rotor, LCOE, weight reduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Large Discrete Structures' in the context of a Horizon 2020 call.

assistant: **Objectives**

The proposed project seeks to introduce novel methods to analyze and approximate large graphs and other discrete structures and to apply the developed methods to solve specific open problems. A need for such methods comes from computer science where the sizes of input structures are often enormous. Specifically, the project will advance the recently emerged theory of combinatorial limits by developing new insights in the structure of limit objects and by proposing a robust theory bridging the sparse and dense cases. The analytic methods from the theory of combinatorial limits will be used to analyze possible asymptotic behavior of large graphs and they will be applied in conjunction with structural arguments to provide solutions to specific problems in extremal combinatorics. The obtained insights will also be combined with methods from discrete optimization and logic to provide new algorithmic frameworks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Search for the Lepton Flavour Violating Decay Tau to Lepton + Gamma at the Belle II Experiment' in the context of a Horizon 2020 call.

assistant: **Objectives**

I propose a measurement of the lepton flavour violating (LFV) tau -> lepton + gamma decay, where the lepton is a muon or an electron. This will be carried out at the University of Pisa (Italy) under the supervision of Prof. Francesco Forti. Although highly successful, the Standard Model (SM) of particle physics does not completely describe all the phenomena we observe, such as the recent discovery of neutrino oscillations which violate lepton flavour conservation in the neutral sector. Many scenarios have been advanced to extend the SM into a bigger picture; several of these models predict LFV to occur in the charged sector as well at measurable rates.I will exploit the unprecedented data sample provided by the Belle II experiment at SuperKEKB to measure the tau -> lepton + gamma decay rate with a sensitivity of at least a factor of four greater than any previous measurement. In order to achieve this result I will develop an advanced physics analysis, making full use of the characteristics of the state-of-the-art Belle II detector and incorporating modern techniques such as machine learning. I will use my experience in physics analysis, preparatory studies and detector performance measurements to make this possible.The impact of a measurement of such sensitivity would be tremendous. A discovery of charged LFV would constitute an enormous breakthrough which would spark a new era of particle physics; a non-observation would instead place strong constraints on possible extensions of the SM and inform physics studies for the coming decade.


**Keywords:** Tau physics, Lepton flavour violation, Physics beyond the Standard Model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Live Cell Spectroscopy Analysis for Personalised Particle Radiation Therapy of Metastatic Bone Cancer' (BoneOscopy).

assistant: **Innovation**

Metastatic bone cancer is an incurable disease and one of the most complex cancers to treat. Due to the high dose, tumour imaging is currently performed at the beginning and end of standard particle radio-therapy (PRT), making personalised treatment difficult. The main goal of BoneOscopy is to develop a radically new technology to enable informed medical decisions by monitoring bone cancer on a daily basis during PRT. At the heart of BoneOscopy is the ability to detect prompt gamma (PGs) emitted by cancer during PRT and separate them from healthy tissue, unlocking the full potential of spectroscopic analysis without the need for additional dose. The development of a highly specialised detection and collimation system will enable accurate spectroscopic analysis of a very small volume or region within the cancer. As the number of PRT centres grows, we anticipate that within 10 years BoneOscopy will benefit all patients treated with proton and carbon ions. The objectives of BoneOscopy will be achieved by its interdisciplinary consortium, which brings together six partners from five European countries with key expertise in bioengineering and PRT (DKFZ), medical physics and engineering (CSIC), fast electronics for PRT (LIP), Monte Carlo simulations and clinical PRT experience (THM), turnkey software for high performance medical devices (Cosylab) and EU project management, communication and dissemination (accelCH). If achieved, the proposed science-to-technology breakthrough will have a transformative impact on current cancer treatment by providing a safe, personalised and quantitative measure of daily treatment efficacy, thereby contributing to the global fight against cancer. In summary, BoneOscopy will lead to a significant reduction in the health burden in Europe and worl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Laboratory Nazionali di Legnaro' to be submitted under Fourth Framework.

assistant: **Abstract**

Principal characteristics of the facility and of the support offered to users: The INL of INFN are a reference point for Nuclear Structure research in Europe due to the presence of a reliable acce1erator system, XTU-Tandem+ALPI superconducting linac delivering more than 5000 hoursiyear of heavy ion beams, and the two biggest gamma-ray spectrometers in Europe. The EUROBALLIII spectrometer, result of an EC Network involving 6 countnes (IT, DE, FR, GB, DK, SE), with 239 GeHp detectors is the most efficient apparatus in the world for studies on the Nuclear Structure of high, super and hyper deformed nuclei. The complex GASP, 40 GeHp gamma array, coupled with RMS, high resolution recoil mass spectrometer, is an unique instrument for the study of nuclei far from stability. Two Van de Graaf accelerators (2 and 7.0 MV), each delivering about 2500 hours/year of light ion beams, are devoted to Applied Nuclear research (radiation damage, radio biology, microdosimetry), Solid State, Medical and Environmental Physics. Avail;able facilities include setups for: calibrated neutron beam, cells and material irradiation, hydrogen profiling, micro-beam, high resolution RBS. A molecular biology laboratory supports radiobiology activities. A Positron-Electron Tomograph PET is also available for cancer diagnostics. The Material Laboratory is equipped for deposition of thin films, ion implantation, electron microscopy, mechanical and electrical characterization. Research is mainly focused on the development of advanced nuclear detectors. Fundamental Interactions research is also developed in the LNL. The ultra-cryogemc gravitational wave detector AURIGA is operative and part of the international network of similar detectors. The LNL Accelerator Technology division, after the completion of ALPI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CREB-dependent mechanisms regulating neural stem/progenitor cell proliferation and neurogenesis' in the context of a Seventh Framework call.

assistant: **Objectives**

Amongst the many factors regulating neural stem and progenitor cell (NSPC) proliferation, survival and differentiation, transcription factors are important factors governing gene expression in NSPCs. Several recent reports indicate that the prototypical transcription factor, cyclic-AMP Element Binding protein (CREB) displays restricted constitutively activated expression in mouse brain neurogenic zones. Germline and conditional panneuronal-specific inactivation of the Creb1 gene has shown the critical role CREB plays in neuronal survival. Closer examination of these mutant mouse brains also indicates significantly reduced cerebral size, implying CREB has a role in neurogenesis, independent of neuronal loss. Our most recent studies have made some progress toward deciphering the role of CREB in NSPCs using zebrafish as a model, where we found that we could modulate neurogenesis by modulating CREB activity. However, knowledge of the role of CREB in mammalian NSPC function is still at an early stage. Using state-of-the-art molecular genetic techniques and bioinformatics approaches, this proposal aims to thoroughly investigate the role of CREB in mammalian NSPCs in vitro and in vivo, during both mouse development and in the adult mouse brain. The study will also investigate whether CREB also has a role in the development and growth of brain tumors. Since CREB is widely expressed and many of the molecular networks between NSPCs and other stem cell types are shared, I anticipate the data obtained from this project will be applicable, not only to neural stem cells but to many other tissue-specific stem cells.