RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ultrastrong Composites through Polymers Interlocked with carbon NanoTubes' (PINT), addressing dissemination and exploitation.

assistant: **Impact**

The reinforcement of polymers with carbon nanotube fillers has been one of the most active areas of research in CNT science. Several materials where the mechanical and/or electrical properties of polymers have been significantly improved using nanotube fillers have been demonstrated. However, the improvement in mechanical properties of the CNT-polymer composites remains far behind the idealized theoretical predictions. These disappointing experimental results are due to a combination of imperfect individualization of the CNTs and poor load transfer from the polymer to the CNTs. To address these problems, several approaches have been investigated, including covalent and supramolecular modification of the CNTs, and different fabrication methods for the CNT-polymer composites, but none has been completely successful.We will explore the direct connection of the polymer matrix to the macrocycles to form Polymers Interlocked with carbon NanoTubes (PINTs). In PINTs, the polymer and SWNTs are linked through mechanical bonds, and therefore form a single molecular entity, a true conceptual leap from previous approximations. The PINT strategy addresses all the critical issues for SWNT-polymer composites at the same time: effective control of SWNT-polymer interface through non-covalent but very strong mechanical bonds, SWNT-polymer alignment, and individualization of the SWNTs.The IP and business parts of this proposal will be carried out in collaboration with Nanocore (http://www.nanocore.com/), a company based in Denmark specialized in the reinforcement of polymers with carbon nanomaterials. In direct cooperation with Nanocore, we will explore the first steps towards commercialization of the technologies developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling the secretion machinery for virulence factors in apicomplexan parasites' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Apicomplexan are obligatory intracellular parasites. The ability of these parasites (Plasmodium, Toxoplasma) to cause disease depends on the coordinated secretion of specialized secretory organelles. The rhoptries are particularly important, because they act as the apicomplexan equivalent of bacterial secretion systems. They inject parasite proteins directly in the cytoplasm of host cells not only for invasion but also to hijack host functions crucial to establish and maintain infection. However, in contrast to bacteria where the secretion machinery has been resolved to atomic detail, how eukaryotic parasites secrete and inject rhoptry effectors into cells is an enigma. This proposal aims to dissect the mechanistic steps and the molecular components that assemble the rhoptry secretion machine. Our aims are:1- To explore the mechanisms that trigger rhoptry exocytosis upon binding of the parasite to the host cell. 2- To provide insights into fusion machinery of rhoptry with the parasite plasma membrane. Our model is based on the discovery that free-living Ciliates and intracellular Apicomplexa share an evolutionarily conserved blueprint for their fusion mechanism.3- To test and expand our hypothesis that rhoptries deliver their content through a transient pore formed into the host cell membrane. We will employ powerful experimental systems in Toxoplasma, Plasmodium and the Ciliate Tetrahymena, taking full advantage of the relative strength of each model. This comprehensive project will bring together comparative genomics, targeted and global genetics, biochemistry, high resolution imaging and electrophysiology.This project answers a question of fundamental biological importance. How can a parasite sense the host cell and inject virulence factors to attain control? Underst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering the molecular mechanisms governing PARP14 ADP-ribosylation activity and its interplay with ubiquitylation signalling' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Intricate networks of post-translational modifications (PTMs) shape how cells respond to environmental threats. Adenosine diphosphate (ADP)-ribosylation (ADPr) has emerged as a pivotal PTM elicited by DNA damage or host immune responses to combat viruses, including SARS-CoV-2. This protective ADPr signature can be regulated by PARP14, a versatile enzyme that can both install and remove ADPr. While the connection between ADPr signalling and these damaging events is clear, the physiological targets and functions of PARP14-mediated ADPr remain ill-defined. Recently, a cryptic link between PARP14 ADPr and ubiquitylation signalling has arisen, adding complexity to PARP14-regulated processes. This ambitious research program ‘UbADPrLINK’ aims to dissect the mechanistic underpinnings of PARP14 ADPr and its link with ubiquitylation using an integrative approach, merging proteomics, structural, biochemical methods.UbADPrLINK will focus on four areas. First, we will precisely map and characterise cellular PARP14-catalysed ADPr sites on important targets by reconstituting ADPr in vitro. Concurrently, we will study the structure-function relationships of PARP14 and explore the roles of uncharacterised PARP14 domains and auto-modification in regulating its activity. Next, we will attempt to decipher the interplay between PARP14 and the PARP9-DTX3L complex that is known to regulate PARP14 activity using unclear mechanisms. We will structurally characterise the PARP14-PARP9-DTX3L complex and assess its potential to simultaneously modify targets with ADPr and ubiquitin. Finally, we will launch a drug discovery campaign to discover cyclic peptides capable of modulating SARS-CoV-2 by targeting PARP14 and SARS-CoV-2 domains involved in ADPr during infection.By seeking to unravel the molecu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Patient-specific stem cell-derived models for Alzheimer’s disease and related neurodegenerative disorders' (STEMMAD).

assistant: **Concept**

Future treatment of incurable neurodegenerative disorders, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), spinocerebellar ataxia (SCA), and Huntington’s disease (HD), has to be tailored to individual patients or cohorts of patients to obtain an optimal effect. The STEMMAD project is aimed to create a highly innovative international collaboration between 2 R&D intensive SME and 3 distinguished academic partners, including one ICPC Third Country partner. The program will enhance the competitiveness of the SME partners and will have a great impetus in an area of immense societal importance: Neurodegenerative diseases and their potential cure. It is our overall aim, by advanced molecular tools, to derive patient-specific in vitro neural cell models that will allow for such customized treatment. Skin biopsies and blood samples will be collected from genetically and clinically well-characterized patients. Fibroblasts and mononuclear blood cells will be isolated and reprogrammed into induced pluripotent stem cells (iPSCs), which, in turn, will be differentiated into neural progenitor cells (NPCs) and specific neurons. We expect that these neurons will express molecular characteristics of the patient’s “disease phenotype” and thereby be representative as patient-specific neural cell models. The models will be characterized for functional disease parameters, used for studies of molecular pathogenesis. The iPSC reprogramming and neural differentiation will be controlled by advanced molecular technologies including manipulation of microRNA (miRNA) expression as well as the use of plasmid minicircles with reprogramming factor genes, thus leaving the genome free of transgenes. To ensure the success of the project, direct transdifferentiation of fibroblasts into n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Standards and test methods for laser beam parameters'.

assistant: **Concept**

Laser materials processing technology will only realise its full potential within Europe when processing results can be reliably measured, documented and reproduced elsewhere. This demands the development and adoption of adequate and standardised means of measuring the important laser parameters. The proposed thematic network in this area will inform and update laser users/suppliers, and provide a means for their comments and concerns to be fed back into the standards under development. The important objectives of the network will be: - To support the introduction of ISO standards on laser beam measurements within the European Community. - To establish a platform for awareness raising relating to laser beam measurements within the laser industry. - To bring together research carried out within the EU relating to laser beam measurements, in particular with respect to inter-comparison experiments. - To provide a mechanism for the coordination of national activities and the development of measurement standards relating to laser beam characterisation. Due to the need to harmonise the standards for laser beam measurements in Europe, the establishment of a network in this field appears very feasible. In particular, due to the difficulty of establishing traceability in some laser beam measurement areas back to national standards, the network will provide an important platform for intercomparison experiments. Partners will be sought from the areas of ISO committees and working groups, research organisations working on equipment design, development and accreditation, commercial manufacturers of test and measuring equipment, builders and suppliers of laser systems, and industrial users of such equipment. The latter are seen as the most important players in this network. Mechanism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High solar fraction heating and cooling systems with combination of innovative components and methods' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The HIGH-COMBI project aims at developing high solar fraction systems by an innovative combination of optimized solar heating, cooling and storage technologies. In the research phase, different configurations will be examined and optimized by detailed simulations. Demonstration plants will be constructed, using different combination of technologies, components and control strategies.All demo plants will achieve high solar fractions values with a sound economy; for some of the plants more than 70% of coverage for the space heating, domestic hot water and cooling loads is expected to be reached. Innovative techniques, components and/or configurations will be examined (e.g. new storages, use of rejected heat during cooling, combined heating and cooling control etc.) Demonstration plants monitoring data of about 15 months will be analysed, the simulation and design tools validated and the plants" performance evaluated."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The momentum polytopes of nonholonomic systems' (ROBOTTOPES) under Horizon 2020.

assistant: **Objectives**

The plan of the project is to extend momentum polytope theory for the standard momentum mapping three different scenarios: (1) the case of contact hamiltonian systems; (2) the mathematical description of nonholonomic (robotic) systems and (3) multisymplectic field theories. The state of the art of research on momentum polytopes has been primarily focussed on the theoretical aspects rather than interdisciplinary research and applications, so this work will open up new grounds of research. The study of general multisymplectic manifolds is not only crucial to understand dynamics but is also of great independent interest e.g. for the quantisation of mechanics or field theories.


**Keywords:** Symplectic Geometry, Motion, Robotics, Wheel movement, Mathematical modelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Wideband satellite demonstrator of multimedia services' (WISDOM).

assistant: **Innovation**

Main ObjectiveOver the last two years or so there has been a growing interest in the use of advanced satellite technology to provide multimedia services. Many systems have been proposed and filings for spectrum have been made by a number of sponsoring organisations. As was the case with the mobile telephony satellite systems (e.g. Iridium, ICO, Globalstar), a wide range of orbit classes and technical approaches have been proposed. The work to be performed in the WISDOM project has the principal objects of refining a baseline design, demonstrating the design with a sophisticated end-to-end test bed and seeking to contribute to possible standards for satellite multimedia services.The system baseline has adopted ATM switching onboard the satellites so that the User Network Interface (UNI) with the ATM network is extended out to the user terminal rather than being at the gateway station. The air interface requires additional coding to achieve the target bit error rate over a satellite link. Onboard the satellite ATM cells are switched between ports connected to particular antenna spot beams or to inter-satellite links. Services supported by the system range from low data rate telephony like services to high rate services up to 2 Mbit/s for standard terminals and up to 6 MBit/s for larger terminals. The system is designed to deliver bandwidth-on-demand services at competitive prices. Low user charges will be realised by employing advanced digital processing technology in the satellite thereby allowing very high traffic capacities of over 10 GBit/s per satellite. An objective of the WISDOM project is to demonstrate the technology.Technical ApproachThe approach to be taken in the WISDOM project is to firstly elaborate the system design including the space segment, the ground s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'AN IN VIVO BIOENGINEERED CHIP AS A SMART INTRAVITAL MULTIPHOTON IMAGING WINDOW FOR NEW VALIDATION PROTOCOLS OF BIOMATERIALS' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Routine clinical use of biomaterials requires the reduction of the economical and ethical costs of biocompatibility tests (ISO10993 EU norm) which are unsustainable for small-medium industries and for the society. In this project we foster an unprecedented breakthrough in in-vivo optical imaging that will radically renew the biocompatibility tests of biomaterials.A micro-structured chip, built by two-photon laser polymerization (2PP), will be implanted in lab animals, host a biomaterial and contain micro-features that guide the spontaneous regeneration of vascularized tissue within a thin gap (0.15mm) in contact with the biomaterial and act as beacons to correct the optical aberrations. The same chip carries a micro-lenses array for in-situ multi-spot imaging, with no need of external high numerical aperture objectives, dramatically improving light penetration in tissue. This chip will recast our thinking of deep tissue in-vivo imaging: the mice carry their own imaging optics, thus reducing substantially image aberration issues allowing unprecedented quantitative and longitudinal analyses of the host inflammatory response to the implant, without sacrificing the mice at each time step. The project will allow unique quantification of the immune reaction to biomaterials at the cellular level (scientific impact), reduce (at least threefold) the number of used animals (societal impact) and the costs of biomaterial discovery (economical impact), and will Refine and Reduce protocols for biocompatibility on a single revolutionary device (regulatory impact). We open here a new visionary path for in-vivo imaging with high Replacement potential in oncological pharmaceutics and immune-therapies. 4 academic units, 1 public research institute and 2 SMEs ensure a highly inter-sectoria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Getting Small and Medium-sized Enterprises from Candidate countries To INcrease participation on IST projects'.

assistant: **Objectives**

The aim of Get-IN is to address the problem of the low participation rate of Associated Candidate Countries' SMEs in the IST thematic priority with an approach based in four main axis: - Develop and deploy of a participation toolset, capable of guiding ACC SMEs through the different stages of IST-related proposal submission; - Design an SME-focused support service package to help them building-up their ideas into projects; - Conceive a set of training sessions, focused in both the toolset manipulation and in the familiarisation with the 6FP instruments; - Set up a dissemination plan, designed to create awareness in ACC countries towards the current opportunities of the IST thematic priority. These four axis interact, converging to the following objectives in terms of SME participation: - provide specific training to 240 SMEs from the participating countries; - select a target group of SMEs from the training sessions and assist them in the expansion of identified ideas into projects - a target of 20 projects (among CRAFTs, STREPs and IPs) is foreseen; - brief a minimum of 1000 SMEs from the 6 involved countries in the opportunities and related instruments of the IST thematic priority of the 6FP.In order to achieve these goals, an ACC representative consortium has been set up.The project consortium is composed of a coordinator organisation - INOVA+ S.A. - with a large experience of promoting SME participation on IST projects and of training services at European level, and six innovation agencies in six candidate countries - Centre for Advanced Technologies (Romania), Applied Research and Communications Fund (Bulgaria), Lithuanian Innovation Centre, Latvian Technological Centre, BIC Bratislava (Slovakia) and Centre for Technology Transfer (Wroclaw, Poland).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'LAW, STATE, REPUBLIC:  An Interpretation and Defense of a Kantian Critical Reflective Constructivism' to be submitted under Horizon Europe.

assistant: **Abstract**

LSR will defend a novel interpretation of Kant’s Doctrine of Right which will allow a reevaluation of LSR will defend a novel interpretation of Kant’s Doctrine of Right which will allow a reevaluation of central issues of his political and juridical philosophy from both the historical and systematic points of view. It will also elaborate new Kantian perspectives for dealing with contemporary normative challenges in the fields of political philosophy, philosophy of law, and political and legal theory. It will investigate two groundbreaking hypotheses. First, that Kant's philosophy of law and right is permeated with the use of reflecting teleological judgment which influence the meaning and normative content of the rational principles of right. Teleology sets up a complex relationship between the a priori and the empirical levels, between practical reason and the pragmatical anthropology as well as between the procedural and dynamical aspects embodied in a specific conception of history. Second, that on a deep methodological level, Kant's philosophy can be understood as grounded in a reflective constructivism that can be developed and updated as a powerful philosophical method for dealing with complex problems about the relation of different forms of normativity, the issue of interdisciplinarity, and the relationship between theory and practice. From the development of those hypotheses, it will be investigated how Kant’s philosophy of right may present innovative solutions for issues such as the following: the relation between external coercion and normativity in the context of the theories of juridical positivism; the requirements concerning the ideal of the rule of law; the relation among the principles of right and history and anthropology; and issues regarding the leg