RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain'.

assistant: **Objectives**

The overall aim is to further the understanding of the BBB in health and disease states towards the development of innovative brain delivery systems, especially for biopharmaceuticals (e.g., peptides, antibodies, etc.) and the identification of novel disease drug targets (Alzheimer’s Disease, MS, metabolic disease).  The related key deliverables will be as follows:1.Identification and validation of specific genes and/or mechanisms  which are altered in brain endothelial cells in disease.2. Generation, validation and characterisation of robust and predictive iPSC-derived BBB models: The developed models should be more reflective of the in vivo situation than existing models, in the healthy and disease states. 3. New, efficacious and safe mechanisms and technologies of brain delivery:   The output of this topic should also result in an expanded and deepened understanding of the fundamental processes that underpin drug-trafficking across the BBB, which in turn can further support endeavours to elucidate novel and more efficacious brain delivery mechanisms.4. Characterised new genetic models for the diseases of interest in this topic which are better amenable to evaluate disease-modifying agents. 5. Characterised mechanisms of neurotropic virus-mediated BBB and CNS penetration for development of selective brain delivery systems.6. Established in silico/mathematical models in predicting BBB penetration of therapeutics (such as receptor-or carrier-mediated transcytosis for delivery across the BBB) and pharmacokinetics of biopharmaceutics in different compartments of CNS.7. Identification of relevant translational readouts which are better amenable to elucidate the role of the BBB in the pathogenesis of neurodegeneration and could eventually lead to new targets for the treatme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Growing Up in the Digital Age of Disinformation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Disinformation is a growing and pervasive problem in modern society. Adolescents spend over 6.5 hours per day on their smartphones and many use social media as a primary information source. There is ample indication in the developmental science literature that adolescents might be particularly susceptible to disinformation. Yet surprisingly little is known about how susceptibility to disinformation changes throughout adolescence and how we might foster youths resilience against disinformation. Here I propose an innovative research program to develop the first comprehensive account of susceptibility to disinformation during adolescence. With this fundamental knowledge, I will develop new instruments to promote truth discernment in youths, which are urgently needed in todays digital era. While many prior developmental studies rely on self-reported online activities, the proposed research will innovate this field by gaining deep and objective insights by applying natural language models to adolescents social media data, computational models of reinforcement learning and decision-making in novel experimental paradigms, and network analyses to capture the interplay between risk factors. This approach will gain novel and necessary insights into: 1. the types of (dis)information that adolescents encounter on social media. 2. How persuasion techniques affect adolescents' veracity judgements and information sharing decisions. 3. The learning processes that underlie social influence and impact adolescents veracity judgements and information sharing decisions. 4. The individual differences which make adolescents more susceptible to disinformation and extreme views. The findings will result in a comprehensive, fundamental understanding of adolescents susceptibility to disinformatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Demographic Uncertainty' (DU).

assistant: **Innovation**

The aim of my research project is to build a mathematical model for the quantitative assessment of the effects of demographic changes on economic activity. It is an ambitious project as it involves the integration of the latest developments in demographic and economic models. It is also highly innovative as it proposes an original treatment of demographic uncertainty. Most existing models consider demographics as a deterministic variable and foresee a set of scenarios. At best, the models incorporate demographics as a risk variable and assume that agents know the stochastic process underlying the demographic dynamics. In the present research project, I wish to build a demographic-economic model in which the future demographics are uncertain. This will have three consequences. First, individual decisions are different and depend on the individuals' attitudes towards uncertainty. Second, the aggregation of individual decisions is more complex, especially because of the fact that the latter are not necessarily temporally consistent. Third, the approach to economic policy is renewed. The government is not necessarily perceived as an omniscient being who corrects market dysfunctions, but rather, it is itself under uncertainty and must compromise with the choices made by agents.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Superconducting Parametric Amplifier Receiver Technology for Astronomy and Fundamental Physics Experiments' to be submitted under Horizon Europe.

assistant: **Abstract**

The emerging technology of superconducting parametric amplifiers (SPAs) can achieve quantum-limited sensitivity over a broad bandwidth by utilizing the wave-mixing mechanism in a nonlinear transmission medium. They are compact, easy to fabricate with planar circuit technology, have ultra-low heat dissipation, and can be integrated directly with other detector circuits. Their performance surpasses that of the state-of-the-art high electron mobility transistor (HEMT) amplifiers, and they can operate from radio to THz frequencies. Therefore, they have the potential to revolutionize almost every kind of microwave, millimetre (mm), and sub-mm instrumentation, from observational astronomy to fundamental physics experiments such as dark matter searches, quantum information platforms, and neutrino mass determination.In this proposal, I will:1. Develop practical ultra-broadband quantum amplifiers for deployment to mm/sub-mm/THz astronomical receivers and fundamental physics experiments.2. Develop novel ultra-compact parametric frequency converters to replace traditional superconductor-insulator-superconductor (SIS) mixers and Schottky local oscillator (LO) technologies, enabling the construction of large pixel-count systems for mm-wave heterodyne receivers such as the Atacama Large Millimetre/sub-mm Array (ALMA) and Event Horizon Telescopes (EHT).3. Explore high critical temperature superconductors to extend the operation of these parametric devices into higher bath temperatures and frequencies in the supra-THz regime, potentially replacing hot electron bolometer (HEB) mixers and quantum cascade lasers (QCLs).The successful delivery of these outcomes marks a paradigm shift in mm/sub-mm/THz instrumentation, replacing all the core technologies used in this regime with a single int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel Approach to Systematically Characterize Exercise- and Nutrient- responsive genes in Type 2 diabetes and cardiovascular disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Proposal summaryType 2 diabetes and cardiovascular disease are devastating and costly morbidities whose prevalences are increasing rapidly around the world. As such, there is an urgent need to develop innovative and effective prevention and treatment strategies. As numerous clinical trials have shown, lifestyle modification is by far the best way to prevent these diseases, with lifestyle being twice as effective as the best drugs, less costly and free from side effects. Yet, human biology is complex, causing some people to respond well and others poorly to the same lifestyle interventions. Thus, a huge, as yet unrealised opportunity exists to optimize the prevention and treatment of cardiometabolic diseases by tailoring lifestyle interventions to the patient’s unique biology. NASCENT is an integrated programme of research through which I will functionally annotate and later translate discoveries of gene-lifestyle interactions made through the interrogation of large epidemiological (N>100,000) datasets at my disposal. The functional annotation of these discoveries will be done using state-of-the-art epigenomic and targeted gene editing tools, whereas the translation of those findings will be achieved using a innovative and powerful clinical trial design that focuses on treatments that are tailored to the participant’s genotype (genotype-based recall). NASCENT capitalizes on a solid foundation of cohorts, methods, and expertise that I have built-up over the past fifteen years, but also exploits state-of-the-art epigenomic and gene-editing technologies that have not previously been used in studies of gene-lifestyle interactions. I expect the integration of these established and new approaches in NASCENT to propel major advances in understanding gene-lifestyle interactions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Longitudinal Educational Achievements: Reducing iNequalities'.

assistant: **Objectives**

Europe is home to some of the most highly educated societies in the world. However, deep inequalities in education remain both within and between countries in Europe. Inequalities in learning outcomes, access to education and final educational attainment in Europe have been worsening and it is important to understand how socio-economic status, gender, ethnic and migrant status are associated with inequalities over the life-course. For this a longitudinal approach is needed and project LEARN (Longitudinal Educational Achievements: Reducing iNequalities) will highlight short-, medium- and long-term patterns of inequalities with a view to supporting educational policymaking in being able to robustly address these inequalities with interventions which are evidence based. Using a case study approach in nine carefully selected countries which capture the diversity of Europe’s education systems, LEARN will map and collect existing data providing original analysis of a range of high-quality education focused longitudinal educational data sets across Europe. LEARN will identify interventions that compensate educational inequalities by providing a synthesis of existing work across Europe examining specific trends in educational inequalities and interventions intended to reduce them. LEARN will then go on to develop tools for policymakers related to the findings of longitudinal analysis which support them in the policy making process.  Through improving the evidence base for education policy making, the positive impact of LEARN is likely to be felt for decades to come.


**Keywords:** Longitudinal, Inequality, transitions, wellbeing, comparative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of an immune-armed therapeutic adenoviral platform for pediatric brain tumors' to be submitted under Horizon Europe.

assistant: **Abstract**

Diffuse Midline Gliomas (DMGs) are the most aggressive pediatric brain tumors in desperate need of curative treatment. The median life expectancy of these children remains below 14 months after diagnosis, and nearly none survive beyond the second year. Similarly, for other high-risk pediatric brain tumors, there is hardly any option after recurrence, and long-term survivors are faced with life-long sequelae that impact their quality of life. In this scenario, there is an urgent need for innovative, efficacious, and safe therapies for these patients. Oncolytic viruses are promising anticancer biotherapeutic agents that offer a unique combination of safety profile, direct antineoplastic activity, and the induction of anti-tumor immune responses. Recently, a Phase I clinical trial showed that combining the oncolytic adenovirus Delta-24-RGD and radiotherapy is non-toxic and results in anti-tumor responses and prolonged median overall survival (17.8 months) in patients.  However, results are still insufficient to be curative due to counteracting mechanisms intrinsic to the tumor microenvironment and also triggered by the virus that eventually exceeds its immunostimulatory properties. The proposed technology, termed “POPCORN”', is an oncolytic-based platform capable of expressing immunomodulatory single-domain antibodies directed to intrinsic targets in these tumors. We will develop the POPCORN Proof of Concept using a state-of-the-art experimental approach and validate its safety and efficacy in vitro and relevant in vivo DMG models. We will also perform IND-enabling studies and apply for PUMA/PRIME designation.  Additionally, we will work on the IPR strategy, and a value proposition to develop and commercialize the POPCORN platform will be generated. We envision the POPCORN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '(Co)homology and computation' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The project aims at: Investigating the homological properties (Hoschild and cyclic (co)homology of algebres defined by monominal relations. This will be done with the help of minimal resolutions fine grading and symbolic computation. Taking part in the development of GL, a programming language suitable for demanding mathematical applications. Training content (objective, benefit and expected impact) Broadening of competence in relevant areas (algebraic topology, category theory, K-theory). Acquiring new competence in computer science. This will make it possible to do more relevant mathematical research, as well as doing valuable contributions to the GL project. Links with industry / industrial relevance (22) The GL project involves both academic and industrial partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scalable real-time monitoring of 3D cell cultures with electrical impedance microtomography' under Horizon Europe.

assistant: **Concept**

High-throughput functional drug testing on patient-derived 3D cell cultures offers unprecedented opportunities for personalized cancer medicine. Optical microscopy constitutes a bottleneck in this approach as it cannot provide rapid information on cell and tissue viability and is not compatible with upscaling. To address this issue, I focus my research project on local electrical impedance spectroscopy to enable the real-time and label-free monitoring of large arrays of 3D cell cultures. The vision is to combine integrated arrays of microstructured organic mixed ionic-electronic conductor devices with multifunctional 3D micropatterned polymeric layers to achieve two specific objectives: i) focus the ionic currents onto the 3D space where cell aggregates are formed, ii) provide the biological cues for cell assembly and development into 3D functional structures. The rapid acquisition of the electrical impedance matrix resolved in frequency space combined with impedance modelling will provide real-time tomographic information about 3D cell organization, inter-cellular junctions and cellular functionality. As a test case demonstrating high-throughput 3D cell culture experiments, final prototypes will implement 3D tumour models to test cellular therapies suppressing cancer growth. The envisioned technology will constitute a novel platform for the accelerated development of personalized medicines without relying on animal testing. The strong interdisciplinary approach adopted by MITO leverages the high-level expertise of the University of Bologna (12-months return phase, supervisor Prof. Tobias Cramer, expert in materials for bioelectronics) and ETH Zurich (24-months outgoing phase, supervisor Prof. Andreas Hierlemann, expert in electrical engineering and cell cultures). Thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel enzymes from extreme marine environments as a source for value-added targets' in the context of a Horizon Europe call.

assistant: **Objectives**

In Europe, physicochemically extreme environments, such as the volcanic arc in the Mediterranean Aegean Sea, as well as anoxic zones and ammunition dump sites in the Baltic Sea, serve as extreme ecosystems that selectively favors various extremophilic microorganisms. The central tenet of the proposed research is that the extremophiles play important roles in the cycling of nutrients and chemical elements in these environments, representing a vast genetic source of enzymes with high industrial application potential, which needs to be explored. The proposed research involves applying innovative sampling method that use novel remotely operated underwater vehicles at these extreme environments, and conducting investigative exploration of the sites through underwater hyperspectral cameras, imaging measurements, and robotic sensing technologies. These activities will advance both the fundamental understanding of the extreme ecosystems and will supply a wide range of unique samples for exploration and discovery of novel enzymes. The enzymes will be identified and characterized using cutting-edge gene sequencing technologies, bioinformatics, artificial-intelligence tools for structural and functional comparisons, and high-throughput methods. Furthermore, new enzyme production intensification and up-scaling methods will be employed to provide both a range of novel, unique halogenases for manufacture of new pharmaceutical compounds, and an array of carbohydrate processing enzymes for seaweed and chitin biorefining to provide new value-added compounds (alginates, fucoidans, chitin-derivatives) for pharmaceutical, biomaterial and food applications. The program includes a targeted dissemination plan to share of high-impact research results, along with extensive communication efforts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of proteasome in human ageing: implications for anti-ageing strategies' (PROTAGE) under Fifth Framework.

assistant: **Objectives**

Accumulation of damaged proteins is a hallmark of ageing. Protease is the main proteolysis system in charge of damaged protein degradation within the cell. Recent data on human keratinocytes and dermal fibroblasts have shown that protease alterations may be responsible for the age-related drop of quality in cellular proteins. Our project is a concerted attempt to understand this phenomenon, and to find appropriate handles to keep it under control. We will analyse the expression of genes coding for protease subunits and proteolysis activity. We will use phage-display and antibodies to identify age-associated modifications in cellular proteins. We will construct human cellular model systems to investigate the role of protease in senescence and apoptosis. Finally, we will develop a test to screen substances for their potential effects on age-related protease alterations