RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fast and comprehensive structure identification in cryo-ET using deep learning and tomogram optimisation' under Horizon Europe.

assistant: **Concept**

Cryo-electron tomography (cryo-ET) revolutionises cellular structure visualisation, but extracting biological insights is often hindered by limitations of subtomogram averaging (STA). With AlphaFold2's recent breakthroughs in structure prediction, identifying known structures in their 3D cellular context is often more important than structure determination by STA. The TomoFind project aims to significantly improve our ability to identify biomolecular structures within tomographic reconstructions.This goal will be pursued through three interconnected approaches: 1) Developing deep learning tools for rapid and comprehensive identification of known structures in tomograms; 2) Refining data acquisition parameters via mathematical modelling and computational optimisation; and 3) Enhancing reconstruction algorithms to fully leverage advancements from 1) and 2). This highly interdisciplinary project combines applied mathematics, machine learning, and structural biology, and close collaboration between computational and experimental groups ensures practical applicability and maximises chances of success.TomoFind will advance cryo-ET analysis capabilities, enabling investigation of cellular structures and processes at unprecedented resolution and scale. The resulting open-source software will lead to high impact across structural and cell biology research communities.The host institution's world-class technical expertise and state-of-the-art facilities provide an ideal environment for this project. This, combined with the applicant's interdisciplinary background spanning applied mathematics, data science, and computational imaging, forms a strong foundation, crucial for the success of TomoFind. The project will enhance the applicant's skills and network, boosting future prospect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification of the novel regulators for asymmetric cell division using genome wide RNAi screen' in the context of a Sixth Framework call.

assistant: **Objectives**

Asymmetric cell division, in which a cell divides into two cells of different developmental fate, is a fundamental mechanism for generating cell diversity. Although the significance of asymmetric cell division for development of multicellular organisms is widely recognized, asymmetric nature of stem cell division particularly attracts a great deal of attention because stem cells are sources of diverse cells in multicellular organisms and are valuable in regenerative medicine. Therefore, elucidation of the molecular mechanism governing asymmetric cell division will lead to not only comprehension of mechanism by which multicellular organisms are constructed but also improvement of therapy with stem cells.   To divide asymmetrically, cells must establish an axis of polarity to localize cell fate determinants to one side of the cells. During cytokinesis, these determinants are then segregated into one of the two daughter cells to give specific characteristics to only one cell. In the peripheral nervous system, sensory organ precursor (SOP) cells give rise to the four cells, two outer cells (hairs and sockets) and two inner cells (neurons and sheaths), to make up the external sensory (ES) organs through a series of asymmetric cell division. Several such cell fate determinants have been identified from Drosophila mutants with morphological defects of ES organs and the molecular machinery responsible for their asymmetric segregation is beginning to be unraveled in SOP cell lineage.   This project will take a novel systematic approach, genome wide RNA interference (RNAi) screen, to identify many other participants in the process of asymmetric cell division using Drosophila SOP cells. After the identification of the novel molecules responsible for asymmetric cell division throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Unravelling extracellular vesicle heterogeneity to inspire improved therapeutic RNA delivery systems'.

assistant: **Objectives**

The growing number of classes of RNA therapeutics, including siRNA, mRNA and RNA components of the CRISPR/Cas9 machinery, hold the promise of providing new treatment possibilities for almost any disease. However, these interventions require delivery of therapeutic RNA to their final intracellular targets in diseased cells, and delivery efficiency by current RNA nanocarriers is unsatisfactory. Endogenous nanoparticles called extracellular vesicles (EVs) have emerged as promising novel RNA delivery systems, due to their intrinsic ability to transfer biological cargo between cells in a selective manner. In fact, with my ERC StG, I have shown that EVs outperform synthetic carriers in terms of RNA delivery efficiency. However, EVs are a heterogeneous population of vesicles that differ in their targeting and cargo delivery properties, which forms a hurdle for the design of EV-based delivery systems. As methods to separate EV subpopulations and study their characteristics individually are lacking, a fundamentally different approach to address this hurdle is necessary.The aim of UNRAVEL is to reveal how variations in EV composition lead to specialized subpopulations with unique delivery features. Using this knowledge, I will develop the first biomimetic class of EV-inspired synthetic RNA delivery systems. I will pursue three objectives:1) Identify EV subpopulations with unique targeting and RNA delivery properties using a novel EV barcoding strategy2) Define these EV subpopulations in terms of unique surface properties, intracellular trafficking and cargo release3) Apply this knowledge to improve synthetic RNA delivery systems by incorporating molecular features from EV subpopulationsThis work will significantly advance our understanding of the natural targeting and RNA deliver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design by simulation and rendering on parallel architectures ii' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The project is an extension of the ESPRIT project 6173 DESIRE. The DESIRE II project aims to complete the development of the DESIRE rendering software and its interface, for distributed and remote networked communication, the implementation of parallel geometric algorithms for interactive styling, and at the first implementation of a fully functional prototype system for interactive design and engineering of car bodies based on visual feedback through photorealistic rendering and through visualisation of simulated external air flow. This will provide a solid foundation for large scale industrial realisations of the digital mock-up concept.The DESIRE rendering software will be suitable for a wide range of application areas. In addition to the application originally chosen to drive the development in the DESIRE project, i.e., interactive design and engineering of car bodies, these areas will include interactive architectural design and lighting simulation, scientific visualisation, commercial digital film production for entertainment and education, digital media games production and high image quality virtual reality applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Breakthroughs in Quantitative Magnetic resonance ImagiNg for improved DEtection of brain Diseases' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Magnetic resonance imaging (MRI) is one of the most useful and rapidly growing neuroimaging tools. Unfortunately, signal intensities in conventional MRI images are expressed in relative units that depend on scanner hardware and acquisition protocols. While this does not hinder visual inspection of anatomy, it hampers quantitative comparison of tissue properties within a scan, between successive scans, and between subjects. In contrast, advanced quantitative MRI (Q-MRI) methods like MR relaxometry or diffusion MRI do enable absolute quantification of biophysical tissue characteristics. Evidence is growing that Q-MRI techniques detect subtle microscopic damage, enabling more accurate and early diagnosis of neurodegenerative diseases. However, due to the long scan time required for Q-MRI, causing discomfort for patients and limiting the throughput, Q-MRI methods have not entered clinical practice yet. B-Q MINDED aims to overcome the current barriers by developing widely-applicable post-processing breakthroughs for accelerating Q-MRI. The originality of B-Q MINDED lies in its ambition to replace the conventional rigid multi-step processing pipeline with an integrated single-step parameter estimation framework. This approach will unlock a wealth of options for optimization of Q-MRI. To accomplish this goal, B-Q MINDED proposes a collaborative cross-disciplinary approach (from basic MR physics to clinical applications) with strong involvement of industry (2 MRI vendors and 3 MRI-software SMEs). B-Q MINDED proposes a unique training platform that enables young European researchers to develop a holistic view on Q-MRI research and development. The fellows enrolled in B-Q MINDED will have access to a variety of network-wide training events and will gain essential transferable ski
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Painting the landscape of translational control of gene expression through meta-analysis of genome wide data sets' (TRANSLATOMICS).

assistant: **Innovation**

Translational control determines the rate at which mRNAs are synthesized into proteins; regulates biological processes ranging from apoptosis to memory; and shows deregulation in diseases such as fibrosis and cancer. In cancer, dysregulated translational control is associated with worse prognosis in most sold cancer. Despite this, integrated genome wide knowledge of translational control and its regulatory mechanisms is lacking. My new methods for data analysis and mechanistic discoveries allow, for the first time, efficient genome wide studies of translational control. By using all publicly available genome-wide data sets and these methods we will characterize the landscape of translational control by identifying genes and pathways that are regulated translationally; groups of genes that constitute functional translational modules and show co-regulation across many biological conditions; key genes that are highly connected (nodes) and under translational control; network structures that are regulated at the translational level; and mechanisms that mediate such regulation. This information will be used to compare many biological processes to generate an integrated perspective of translational control. Through functional experiments employing both gene specific and regulatory mechanism focused approaches we will link translational control, genes, mechanisms for regulation and biological processes to unravel a new level of understanding of translational control. Such knowledge will be applicable in future studies of how dysregulation of translational control contributes to human disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Pathogen derived Immunomodulatory components as potential mediators of transplant tolerance' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Pathogenic organisms such as bacteria, viruses and parasitic worms have evolved strategies to actively subvert the host immune system, facilitating their persistence. As a consequence, the identification of specific pathogen derived immunomodulatory molecules has become an intense area of research with a number of such molecules having been found to offer potential as immunotherapeutics in animal models of autoimmune disease and allergy. As there is considerable overlap between the cellular immune responses mounted against 'self' antigens in the case of autoimmunity, and alloantigens in the context of transplantation, we will examine whether immunomodulatory components identified from the excretory secretory (ES) products of the helminth parasite, Fasciola hepatica can alter the generation of an alloimmune response. We will examine the influence of specific immunomodulatory ES components on the generation of alloresponses by examining their specific effects on both antigen presenting cells and T cells. Furthermore we will examine the efficacy of specific ES products in promoting transplant tolerance in models of graft versus host disease and organ transplantation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Implanted liver assist system' (ILIAS) targeting Fourth Framework.

assistant: **Abstract**

The prime objective of this proposal is the completion of a process of research and development into the feasibility of an implantable pump, a liver assist device (ILIAS). ILIAS is designed to be positioned in the human hepatic portal system and to be capable of improving liver function and reducing portal hypertension arising subsequent to cirrhosis of the liver.The prime objective of this proposal is the completion of a process of research and development into the feasibility of an implantable pump, a liver assist device (ILIAS). ILIAS is designed to be positioned in the human hepatic portal system and to be capable of improving liver function and reducting portal hypertension arising subsequent to cirrhosis of the liver. To carry out the project a European clinical consortium has been evolved with partners 1, 2 and 3, each of whom is a leading practitioner in the field of liver surgery and treatment. The clinical consortium will work closely with a powerful technological group, with partners 4, 5 and 6. In the UK, part of an ongoing ESPRlT project (IMALP), will determine the behaviour of the pump in liver preparations in vitro. These studies will give way to work in the present proposal, initially on normal pigs and, towards the end of the first year, on pigs with cirrhotic livers. During the first year of the present project, in addition to the animal studies, protocols will be developed preparatory to the implantations of ILIAS pumps into at least ten human recipients during the second and third years. The implantations are planned to take place with at least two in each of the UK centres and three in the other participating clinical centres.The work on pigs and then in man, will be the clinical arm of the project which will be enacted in parallel and in constant i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantum Control for Advanced Quantum Metrology' to be submitted under Horizon 2020.

assistant: **Abstract**

In the last years the novel, potentially revolutionary, possibilities offered by quantum mechanical systems have been deeply explored giving rise to a whole spectrum of Quantum Technologies, which are expected to have a big impact on the everyday life of future generations. Quantum metrology represents one of the most promising of these second generation quantum technologies: its aim is to exploit quantum mechanics to perform ultra-precise measurement not achievable by means of classical approaches. Yet, a major obstacle still stands in the way of their full exploitation: preserving quantum coherence, the necessary ingredient for quantum protocols to outperform their classical counterparts, is a very difficult task. As it happens in ``classical technologies'', where the effect of noise is neutralized by monitoring and controlling the signal and its environment, quantum control is going to play a fundamental role for the development of noise-resilient protocols based on quantum mechanics.The main goal of this fellowship is to develop a more general framework for noisy quantum metrology, encompassing quantum control techniques based on time-continuous measurements and real-time feedback, and considering more general non-Markovian noisy evolutions. Beside answering fundamental questions, we will also design protocols for specific physical systems, with a particular attention for quantum opto-mechanical setups.


**Keywords:** Quantum Information, Quantum Metrology, Quantum Optics, Quantum Control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Training in Quantum Photonics Design Fabrication and Characterisation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The efficient generation of Quantum states of light is a vital task in Quantum Photonics technologies. Current approaches are generally bulky and expensive with low generation rates. The state of art solutions do not scale.In this project, the Fellow l will develop a new integrated photonic platform based on the Lithium Niobate on Insulator platform, which will provide compact and highly efficient sources of the , heralded single photons and entangled photon pairs at the telecommunication that are now vital to the secure transmission of information.The Fellow will be able to use the training provided by the project to restart her career after a break to rear children. Her skills in nanofabrication will be refreshed and brought up to date. She will learn  skills in the discipline of Quantum photonics, which is new to her, including the design design and simulation and the characterisation of the generated quantum states of light. In the final stages of the project, the devices will be validated in an industrial environment and the Fellow will be trained in the requirements of industrial qualification.


**Keywords:** Lithium Niobate, nanophotonics, photonic crystal, heralded single photons, entangled single photonics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The functional interaction of EGFR and beta-catenin signalling in colorectal cancer: Genetics, mechanisms, and therapeutic potential.'.

assistant: **Concept**

Monoclonal antibodies against the EGF receptor (EGFR) provide substantive benefit to colorectal cancer (CRC) patients. However, no genetic lesions that robustly predict ‘addiction’ to the EGFR pathway have been yet identified. Further, even in tumours that regress after EGFR blockade, subsets of drug-tolerant cells often linger and foster ‘minimal residual disease’ (MRD), which portends tumour relapse. Our preliminary evidence suggests that reliance on EGFR activity, as opposed to MRD persistence, could be assisted by genetically-based variations in transcription factor partnerships and activities, gene expression outputs, and biological fates controlled by the WNT/beta-catenin pathway. On such premises, BEAT (Beta-catenin and EGFR Abrogation Therapy) will elucidate the mechanisms of EGFR dependency, and escape from it, with the goal to identify biomarkers for more efficient clinical management of CRC and develop new therapies for MRD eradication. A multidisciplinary approach will be pursued spanning from integrative gene regulation analyses to functional genomics in vitro, pharmacological experiments in vivo, and clinical investigation, to address whether: (i) specific genetic alterations of the WNT pathway affect anti-EGFR sensitivity; (ii) combined neutralisation of EGFR and WNT signals fuels MRD deterioration; (iii) data from analysis of this synergy can lead to the discovery of clinically meaningful biomarkers with predictive and prognostic significance.This proposal capitalises on a unique proprietary platform for high-content studies based on a large biobank of viable CRC samples, which ensures strong analytical power and unprecedented biological flexibility. By providing fresh insight into the mechanisms whereby WNT/beta-catenin signalling differentially sustain