RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Imaginable Impossibilities and Thought Experiments. The Tradition of the Oxford Calculators and its Influence on Early-Modern Logic and Natural Philosophy'.

assistant: **Concept**

The project aims to investigate the tradition of the Oxford Calculators and the influence their works had on early-modern logic and natural philosophy. The Calculators were a group of scholars active in 1325-1350, connected to the tradition of sophismata. An element of novelty in their works is that logical techniques were usually applied to the discussion of mathematical and physical issues. Moreover, their sophismata often involved the use of thought experiments, aimed at challenging and revising parts of the Aristotelian physics, in which many sorts of intricate non-naturalistic cases and impossible scenarios were posited as imaginable. The project firstly aims at reviewing our knowledge of the Calculators’ tradition, along with their academic and cultural context. This will be done mainly through a historical methodology, combining paleographical techniques and archival research. The second objective is to assess whether the Calculators developed a consistent theory of modalities, and how this would be connected to other theories available in the 13th and 14th century. This will require cataloguing and analysing the use of imaginable cases, and individuating the various senses of possibility that are at play in them. A third aim is to evaluate the impact that the Calculators’ works had on early-modern philosophy, and to determine to what extent the Calculators’ achievements in the areas of mathematics and physics (together with their thought-experiment methodology) contributed to the shift from medieval scientific paradigms to a modern view of science. The project combines many disciplines into investigating authors that have played an important - albeit overlooked - role in the history of philosophy and science. Besides its historical interest, the project is relat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterisation of the essential role of the Smc5/6 complex in chromosome metabolism during the eukaryotic cell cycle' under Sixth Framework.

assistant: **Concept**

The process of cell division requires special mechanisms for the accurate transmission of the genetic information. In all eukaryotes, the genome is packaged into linear chromosomes. These are entities that have to be manipulated, replicated, and eventually segregated with high fidelity to opposite poles of the dividing cells. Our understanding of chromosome architecture and dynamics has been recently boosted by the characterisation of two protein complexes, cohesin and condensin, and their regulation by the cell cycle.In concert or shortly before replication, cohesion must be established between replicated sister chromatids and maintained until anaphase to ensure chromosome biorientation and equal partitioning of the genetic material. Besides, chromosomes must be condensed to avoid severing by cytokinesis. These two complexes have in common the presence of an SMC heterodimer at its core. All eukaryotes have a third essential SMC complex, called Smc5/6. As cohesin and condensin, the Smc5/6 is also involved in chromosome regulation and organisation. Despite the fact that it has been linked to DNA repair, the essential role of the Smc5/6 complex remains largely unknown.This project is based on the hypothesis that the Smc5/6 complex has an essential role in chromosome dynamics and structure that ultimately affects chromosome segregation in mitosis. The aim of the proposed research is to further characterise the ill-defined role of the Smc5/6 complex in chromosome metabolism during cell cycle progression and cell division. This study will result in the detailed understanding of the Smc5/6 function at the cellular and molecular level, and will uncover the mechanisms by which this SMC complex keeps the integrity of the genome.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'MAGIC (MAnufacturing of Gene delivery tools for Industrial and Clinical applications)'.

assistant: **Concept**

Founded in 2005, Vectalys is a biotech company that develops world leading gene delivery technologies for industrial and therapeutic applications. Vectalys has built a state-of-the-art proprietary lentiviral vectors (LV) production platform to provide its customers and partners with the highest quality of LV. Based on 10 years of collaborative research, the resulting LV purity is now recognized as a key success factor for cutting-edge stable cell engineering on primary and stem cells. In parallel, thanks to its deep understanding of market needs, Vectalys has developed and patented a game-changing class of RNA carriers called LentiFlash (LF), a new generation of non-integrating LV dedicated to gene-editing applications requiring a transient expression.Bioprocessing know-how, stable and transient delivery tools and intellectual property combine into a unique and powerful integrated platform capable of accelerating both gene-editing and immunotherapy applications. Based on recent results of early CAR-T cells clinical trials, mainly in the US, the market will now need an extensive scale-up capacity to produce GMP-grade LV and LF. The application potential is significant and includes both clinical approaches (gene therapy, gene-editing, and immunotherapy) and industrial systems (synthetic biology, modelling development).Compared to the US, there is in Europe a clear lack of clinical manufacturing infrastructure and of integrated platforms that include both research and GMP production, thereby offering a broad expertise from vector design to therapeutic strategies. From a non-regulatory pre-clinical stage market, Vectalys has the capacity to move forward into the clinical stage market as a GMP grade value provider. The company has taken the technological lead in this field i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimized Structural components and add-ons to improve passive safety in new Electric Light Trucks and Vans (ELTVs)' under Seventh Framework.

assistant: **Concept**

OPTIBODY, is a new concept of modular structural architecture for electric light trucks or vans (ELTVs) that will focus on the improvement of passive safety in order to help to reduce the number of fatalities and severe injuries.This new structural concept is composed of a chassis; a cabin improving current levels of EVs’ comfort, occupant protection and ergonomics; and a number of add-ons bringing specific self protection in case of impacts or rollover, and providing partner protection (crash compatibility) while interacting with other vehicles or vulnerable users. Each module can be individually optimized.OPTIBODY, together with the less restrictive distribution of internal components of EVs (with less architectural constraints than conventional ones) will represent a unique opportunity to implement innovative solutions for passive safety in ELTVs.OPTIBODY, as a module-based design, has also important results in terms of repairability. An optimum choice for the different modules’ features will make repairability and maintenance procedures easier and more cost efficient.Currently, the EVs figures are still reduced, but the 21st century will most likely see the replacement of vehicles relying on the internal combustion engine by EVs (as stated in “A Sustainable Future for Transport”- Communication adopted by the EC -17/06/2009). In accordance with this idea, the”National Development Plan on Electric-Drive Vehicles” (German Federal Cabinet -19/08/2009), plans to get 1 million EVs on Germany by 2020; the Spanish Ministry of Industry intends to reach the 1 million EVs in Spain by 2014; manufacturers like RENAULT have forecasted 6 million EVs in Europe by 2010; besides, encouraging the EV is one of the main objectives of the Spanish presidency of the UE.OPTIBODY will imply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Initiating and interfering with silencing of transposons' (I2ST).

assistant: **Innovation**

There is no living organism that does not contain transposons, and they make up a significant fraction, and in some instances, the vast majority of the genome in a given species. Owing to their proliferation propensity, these mobile genetic elements can create genetic variability providing selective benefits, but they also have a mutagenic potential. Therefore, host genomes have evolved epigenetic surveillance mechanisms to recognize and silence transposons. If maintenance of silencing is rather well understood, little is know about how the host recognize transposons as non-self elements and initiate silencing as they invade the genome. Also, although several examples indicate that a variety of environmental factors can reverse transposon silencing, how such factors interfere with the silencing machinery is largely unknown. The proposed research project will make use of our recent discovery of active endogenous retrotransposons in Arabidopsis to decipher genetically the mechanisms involved in initiating silencing of a transposon. In parallel, we will characterize how DNA-methylation associated silencing can be efficiently re-established once it has been lost, and use a genome-wide approach to determine the extent of this phenomenon. Finally, we intend to determine the genome-wide impact of a stress on transposon silencing and to genetically identify and characterize the molecular bases of stress-induced release of silencing at  transposons. Our studies have the potential to bring general insights into how transposons have been so successful in colonizing host genomes, how they are kept under tight control and can be unleashed thereby contributing to genome plasticity and environmental adaptation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '5G integrated Fiber-Wireless networks exploiting existing photonic technologies for high-density SDN-programmable network architectures' in the context of a Horizon 2020 call.

assistant: **Objectives**

5G-PHOS aims to architect and evaluate 5G broadband wireless networks for dense, ultra-dense and Hot-Spot area use cases drawing from recent results in the area of optical technologies towards producing and exploiting a powerfulphotonic integrated circuit technology toolkit. It aims to streamline advances in multi-format and multi-bitrate optical communications, in InP transceiver, in Triplex optical beamformers and in integrated optical add/drop multiplexers inorder to migrate from CPRI-based towards integrated Fiber-Wireless (FiWi) packetized C-RAN fronthaul supporting massive mmWave MIMO communications.It will deliver: a) a set of SDN-programmable units, called FlexBox andFlexBox-Pro, that will be compatible with the emerging 25Gb/s PON access networks and can deliver FiWi traffic ranging between 25-400Gb/s, b) a set of three different 64x64 MIMO Remote Radio Head configurations exploitinganalog optical beamforming and producing 25Gb/s,100Gb/s and 400Gb/s wireless data-rates, c) an integrated FiWi packetized fronthaul for supporting Medium-Transparent Dynamic Bandwidth Allocation mechanisms andcooperative radio-optical beamforming, d) a converged FiWi SDN control plane for optimally orchestrating both the optical and the wireless resources. These blocks will be integrated towards architecting 5G networks for 3 use cases,evaluating their performance in lab-scale and field-trial experiments: a. 25Gb/s peak data rate PON-overlaid 5G FiWi network for dense areas, capable to offer densities up to 1.7 Tb/s/km2 , to be demonstrated also in field-trial experiments at the deployed network of Greek operator COSMOTE.b. 400Gb/s peak data-rate SDM-enabled 5G FiWi network targeted for ultra-dense environments and being capable of offering densities up to 28 Tb/s/km2 with <1msec la
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Aircraft Modular Power Converter Solutions'.

assistant: **Objectives**

The aim of this project is to demonstrate the use of integrated hybrid power modules in the design of aircraft power converters. The project aims to show that using a standardized power module for various converter topologies will give numerous benefits, including higher power denisty, lower cost and higher reliability.This first part of the project entails the design and manufacture of a Power Module which will form the building block for two different power converter types which can be used in commercial aircraft power distribution applications.The second part of the project entails the demonstration of the use of the power module, which will be developed in the first part of the project, in power converter applications by designing and building a matrix contactor demonstrator, which will demonstrate the benifits of the modular approach, including small size, high effiency and modularity.The project will also look at the trade-offs of different design choices for the power module, in this particular application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SPIKING PHOTONIC-ELECTRONIC IC FOR QUICK AND EFFICIENT PROCESSING' (SPIKEPro).

assistant: **Concept**

Rapid advances in artificial intelligence technologies have led to powerful models and algorithms that have revolutionized many applications across all fields of science and technology. Deep learning performed within artificial neural networks has yielded new ways to process data, leading to sophisticated systems with impressive functionality and benefits. However, conventional computing hardware is reaching its limits in terms of energy efficiency and speed. A new approach to computing hardware is needed. Novel brain-inspired or neuromorphic chips working with biologically-inspired spiking neural networks have gained attention as they promise highly efficient ways to process data. Important research effort has been dedicated to develop such neuromorphic systems in electronic or photonic hardware separately, each with its drawbacks and limitations. SPIKEPro proposes a science-towards-technology breakthrough by combining low-energy electrical and photonic neurons into a joint spiking neural network on an integrated circuit. SPIKEPro’s chip integration approach is based on a common technology platform, connecting ultrafast laser optical neurons with efficient electrical spiking diodes through non-volatile synaptic weights. This enables to simultaneously capitalise on the advantages of both electronics and photonics to deliver efficient and high-speed SNNs going beyond existing implementations. In addition to reducing the energy consumption per spike in the network, SPIKEPro will also develop novel learning strategies and algorithms able to work with reduced number of synaptic connections. These will be possible by exploiting the hardware parameters of the electrical and photonic spiking devices. The outcome of SPIKEPro will have lasting economic, societal and scientific i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metformin Impact on Maternal and Infant Cardiometabolic Health', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Increasing numbers of older, obese women with poor cardiometabolic health (dyslipidaemia, hyperglycaemia, hypertension) are embarking on pregnancy. One in six of these high-risk pregnancies are complicated by an indicated preterm birth due to fetal growth restriction (FGR) or fetal overgrowth and/or maternal complications including gestational diabetes and pre-eclampsia. The cumulative cost of neonatal care, childhood and adult disease in individuals born preterm has been estimated at £1-3 billion pa in the UK.  Older age, obesity, dyslipidaemia and hypertension are major risk factors for placental disease leading to FGR and pre-eclampsia. Conversely, hyperglycaemia is associated with fetal overgrowth and is therefore treated with hypoglycaemic agents such as metformin during pregnancy. In women with hyperglycaemia and concurrent risk factors for placental disease, the impact of metformin on placental function, fetal growth, and postnatal outcomes is not known.  To address this evidence gap, I will perform an RCT which will incorporate a novel method of tracking fetal growth and investigate the impact of metformin on maternal and infant metabolic health at 12 months. The impact of metformin on gene expression and placental function will be assessed in placentas from women exposed (or not) to metformin. In the wider group of women with poor cardiometabolic health, I will map maternal disease biomarkers and fetal growth to molecular placental disease subtypes who have developed a range of pregnancy complications.  The goals of this work are to improve pregnancy outcomes in women with poor cardiometabolic health by, (1) producing evidence to personalise the prescription of metformin (2) refining current diagnostic criteria to better reflect placental disease molecular subt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deployment of Societally Beneficial Nano- and Material Technologies in European Partnership Countries' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

NANOMAT-EPC aims to support the deployment of societally beneficial nano- and materials technologies in European Partnership countries (EPC), in order to increase exploitation of their scientific results and contribute to the United Nations Millennium Development Goals. Consequently, NANOMAT-EPC aims to develop knowledge and technology transfer in nano- and materials technologies for healthcare, clean energy and environment applications. The project will be implemented by a well-balanced consortium of nine partners – four EPC partners and five EU partners.In order to stimulate the knowledge and technology transfer, NANOMAT-EPC’s mission is the following:i. Map and promote organisations involved with nano- and materials technologies in EPC;ii. Organise brokerage events in the EPC to facilitate knowledge and technology transfer in nano- and materials technologies;iii. Organise workshops in the EPC to identify nano- and materials knowledge and technology transfer opportunities;iv. Implement pilot nano- and materials technologies deployment projects. The pilot projects will be bilateral between the EPC and European partners and based on education, training and exchange of scientists as follows:a. Deployment of high conductivity zirconia anodes in solid oxide fuel cells (IPMS and UB)b. Deployment of hybrid CNT/graphene electrodes for supercapacitors (BSUIR and Cleancarb)c. Deployment of nanosensory devices for environmental monitoring using picosecond laser technology (GTU and PSUD)d. Deployment of magnetic nanoparticles for medical applications (IPR-NAS and LZH)v. Produce report with recommendations on how to exploit to nano- and materials knowledge and technology transfer opportunities in EPC.