RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An in vivo imaging approach to understand pancreatic beta-cell signal-transduction', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The challenge in cell physiology/pathology today is to translate in vitro findings to the living organism. We have developed a unique approach where signal-transduction can be investigated in vivo non-invasively, longitudinally at single cell resolution, using the anterior chamber of the eye as a natural body window for imaging. We will use this approach to understand how the universally important and highly complex signal Ca2+ is regulated in the pancreatic beta-cell, while localized in the vascularized and innervated islet of Langerhans, and how that affects the insulin secretory machinery in vivo. Engrafted islets in the eye take on identical innervation- and vascularization patterns as those in the pancreas and are proficient in regulating glucose homeostasis in the animal. Since the pancreatic islet constitutes a micro-organ, this imaging approach offers a seminal model system to understand Ca2+ signaling in individual cells at the organ level in real life. We will test the hypothesis that the Ca2+-signal has a key role in pancreatic beta-cell function and survival in vivo and that perturbation in the Ca2+-signal serves as a common denominator for beta-cell pathology associated with impaired glucose homeostasis and diabetes. Of special interest is how innervation impacts on Ca2+-dynamics and the integration of autocrine, paracrine and endocrine signals in fine-tuning the Ca2+-signal with regard to beta-cell function and survival. We aim to define key defects in the machinery regulating Ca2+-dynamics in association with the autoimmune reaction, inflammation and obesity eventually resulting in diabetes. Our imaging platform will be applied to clarify in vivo regulation of Ca2+-dynamics in both healthy and diabetic human beta-cells. To define novel drugable targets fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Matrix for Chemical IT', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

MATCHIT (MATrix for CHemical IT) will develop programmable information chemistry by introducing an addressable chemical container (chemtainer) production system and interfacing it with electronic computers via MEMS technology with regulatory feedback loops. As in the biological subcellular matrix, the chemical containers at the micro- and nanoscales will be self-assembling, replicable and self-repairing. At the nanoscale, DNA containers will provide a programmable and replicable chemistry in which positional information can be harnessed for a range of nanoscale utilities. At the microscale, containers based on DNA-labeled heterophase droplets and vesicles, will form microscopic labeled reaction vessels that can themselves determine their next processing steps. Their DNA-based addresses will be computable, enabling parallel chemical programming in a new multilevel architecture through autonomous address modification and resolution at the container-container, container-surface, and container-molecule levels, providing a concrete embedded application for DNA computing. This generic programmable information chemistry will not only be an enabling technology for immersed systems" IT applications in the life sciences, chemistry, and nanotechnology, but also promote a deeper understanding of the computational power of coupled production and information processes, as in biology, and provide a platform for building the more organic computers of the future.<br/>MATCHIT will investigate the general use of self-assembling chemtainers for information-intensive Chem-IT. The project will develop and apply multiscale physical simulation tools and novel embedded IT architectures to process and integrate modular chemical and digital information. It will integrate and disseminate multidisc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'eXtreme BENDing strain induced novel interfaces in single crystal cantilevers of strongly correlated metals' (XBEND), addressing dissemination and exploitation.

assistant: **Impact**

The ground state of correlated materials is controlled by tuning parameters such as pressure or strain, which are usually applied homogeneously to crystals. Here we aim for strong yet controlled strain gradient fields in microstructured correlated crystals that selectively transform parts of the structure into different electronic ground states. XBENDs ambition is to open a new field of research into gradient quantum matter, defined as a highly non-linear regime in which gradients lead to qualitatively new behavior as compared to simple spatial distributions of bulk phases.The concrete goal is a rational design of new electronic properties at interfaces between different correlated ground states within a single crystal – akin to the interface states between different materials in heterostructures. Specifically, we aim to frustrate interactions and/or competing orders in unconventional superconductors at this interface, with the goal to enhance the transition temperature Tc. We will create interfaces between (1) ferro-polar and paraelectric phases in crystals of doped SrTiO3; (2) oppositely detwinned domains in underdoped Ba(Fe,Co)2As2 crystals; (3) hidden-order and magnetic phases in URu2Si2. Contrasting their nature and physical responses to those expected from trivial phase mixtures will signal that XBEND has entered a non-linear gradient-driven regime. Technically, we will fabricate free-standing single crystal cantilevers from as-grown crystals using Focused Ion Beam (FIB) machining. The cantilevers will be functionalized to allow cryogenic measurements of magnetoresistance while applying bending strain by pushing them with a piezoelectric motor. XBEND aims for extreme strain gradients in the 10%/micron range, yet our proof-of-concept already demonstrated 2%/micron.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'A consumer oriented prototype – forming the nucleus of a novel Ecological Accounting System'.

assistant: **Concept**

myEcoCost is a foundational methodology that defines a global collaborative network of resource accounting nodes. It provides a means of accounting for and expressing usage of natural resources for products, services and technologies, to inform all economic actors including SMEs (Small and Medium size Enterprise) and consumers, on environmentally relevant information. It is a novel, bottom up approach to measure resource efficiency, the results of which are applicable in corporate, industry and society wide contexts. It is an asynchronous, recursive, non-centralised data gathering and dissemination technique for a large scale stakeholder network.myEcoCost aims to support various environmental accounting and assessment practices applicable to various national and international environment policy objectives. It links business added value to a measurement of aggregated resource usage as accepted environmental pressure indicator which goes beyond single issue indicators such as carbon footprint. Using an Internet-based service-oriented architecture (SOA) relevant and timely data is passed from supplier to customer recursively through the whole value chain to produce “ecoCosts” for each product or service. The project will demonstrate how it is technically possible to provide timely and accurate resource efficiency statements.For this to happen a series of ICT (Information and Communication Technology) infrastructure components will be arranged: A resource accounting framework to determine “ecoCosts”, an ICT delivery mechanism to transfer the measurement from supplier to customer, benchmark figures for companies and consumers linking to macro level policy objectives, and interfaces for industry and consumers to interpret the measurement to assist decision making.The project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Smoothness of the invariant Hilbert scheme of affine spherical varieties for the existence of wonderful varieties'.

assistant: **Innovation**

Let G be a reductive linear algebraic group over the complex numbers. A G-variety, an algebraic variety with an algebraic action of the group G, is said to be spherical if it is normal and has an open orbit for a maximal connected solvable subgroup of G. We aim to complete the classification of spherical varieties by proving Luna's conjecture on a special class of spherical varieties, called wonderful. To a wonderful variety one can naturally associate an invariant combinatorial object in terms of roots and weights, called spherical system. Luna's conjecture states that there exists a one-to-one correspondence between isomorphism classes of wonderful varieties and spherical systems. Given a spherical system, here we want to provide the corresponding wonderful variety by studying the geometric properties of a certain algebraic scheme, called invariant Hilbert scheme, recently introduced by Alexeev and Brion. The given reductive group G acts linearly on the ring of regular functions of any affine spherical G-variety, the corresponding linear representation is multiplicity-free. The invariant Hilbert scheme of Alexeev and Brion parameterises the affine spherical G-varieties with a fixed multiplicity-free representation in their ring of regular functions. It is endowed with an action of a maximal torus of the group G.  Given a spherical system, the strategy is to define a suitable multiplicity-free representation and study the corresponding invariant Hilbert scheme. Via deformation theory arguments we want to prove that under certain conditions the considered invariant Hilbert scheme has an open orbit for the toric action. By a standard procedure, called spherical closure, one can associate to any spherical variety a wonderful variety. Here we want to prove that to an affin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Trial Ready Small Vessel MRI Markers: Proof of Concept'.

assistant: **Innovation**

Problem: Cerebral small vessel disease (SVD) is a hallmark of serious brain diseases such as acute stroke and dementia. It has a major impact on society, since it affects quality of life of many ageing individuals, and increasingly challenges the healthcare resources. Current image-based biomarkers do not reflect SVD itself, but rather macroscopic, irreversible brain damage, secondary to the abnormalities of the small vessels. This greatly hampers development of new drugs as clinical trials lack effective biomarkers directly reflecting SVD. Solution: The SmallVesselMRI  ERC project (337333), yielded 7T MRI methods with the potential to offer a paradigm shift in SVD research. We have developed new MRI measures that, for the first time, allow non-invasive assessment of the condition of the small vessels themselves, including blood flow velocity pulsation in small perforating vessels, which informs on vessel stiffness. The current proof-of-concept project ‘trial-ready Small vEsseL MRI MArkers (SELMA) aims to make these novel promising vascular parameters ready for use in phase II/III clinical trials. Our ambition is to bridge the gap between high end imaging research platforms and widespread clinical MRI, in order to enable drug-target engagement studies in clinical trials for newly developed drugs.SELMA will: 1) Port the small-vessel 7T MRI pulse sequences to clinically ubiquitous 3T MRI scanners. 2) Develop a software tool that can provide robust, automated data analysis. 3) Determine the reproducibility of the SELMA biomarkers in a group of 35 healthy individuals with scan-rescan experiments. 4) Provide clinical proof of concept by a pilot study in 15 patients with SVD, measuring the vascular parameters before and after administration of a pharmaceutical agent.  Using r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Foundational Aspects of Global Computing Systems' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

New global computing and communication environments are emerging that integrate:(a) autonomous, interacting, selfish entities,(b) highly dynamic multi-agent environments and(c) ad-hoc mobile networks.For the efficient and robust implementation of global computing scenarios in such systems, we aim to provide a unifying foundational framework and a coherent set of design rules, focusing on the issues of:(i) co-operation and antagonism of autonomous entities;(ii) stability and fault-tolerance in multi-agent environments and(iii) communication and motion in ad-hoc mobile networks.New global computing and communication environments are emerging that integrate:(a) autonomous, interacting, selfish entities,(b) highly dynamic multi-agent environments and(c) ad-hoc mobile networks.For the efficient and robust implementation of global computing scenarios in such systems, we aim to provide a unifying foundational framework and a coherent set of design rules, focusing on the issues of:(i) co-operation and antagonism of autonomous entities;(ii) stability and fault-tolerance in multi-agent environments and(iii) communication and motion in ad-hoc mobile networks.OBJECTIVESThe project aims to provide a unifying scientific framework and a coherent set of design rules for global systems resulting from the integration of autonomous interacting entities, dynamic multi-agent environments and ad-hoc mobile networks. The focus will be on the issues of co-operation and antagonism, stability and fault-tolerance, as well as communication and motion in such global systems.DESCRIPTION OF WORKTo provide at a foundational algorithmic level a unifying framework and a coherent set of design rules for the robust and efficient implementation of complex and dynamic global systems, the following critical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Provenance And tranSport PathwayS of mArine proxy-bearinG particlEs', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Understanding the nature and pace of climate change in the future requires robust and accurate information on past Earth's climate changes. Much of what we know about past short-term climate variability stems from marine sediment sequences, whose sedimentary components provide an ever-expanding array of paleoclimatic proxies. The fundamental assumption underlying most paleoceanographic investigations is that the environmental signal encapsulated in marine sedimentary components reflects that of the overlying water column at the time of formation. However, evidence indicates asynchronous synthesis and transport from distal locations for co-deposited sediment constituents. Consequently, fundamental questions arise regarding the fidelity of paleoclimate records. Moreover, the magnitude of such temporal and spatial offsets likely varies in concert with hydrographic ? and associated hydrodynamic - changes. Here, I outline a research program to directly assess the impact of hydrodynamic processes on marine particles and explore implications for paleoceanographic studies. Specifically, this research will: (i) estimate the contribution of allochthonous/asynchronous material; (ii) constrain the extent and nature of the specific modes of particle transport; (iii) quantify their potential to bias derived climate signals; (iv) correct for aliased proxy records and reconstruct past hydrodynamic changes. This work would provide a crucial advance in our ability to reliably interpret sub-millennial scale climatic signals. We will develop cutting-edge methodologies for particle isolation and will apply state-of-the art analytical techniques for compound-specific radiocarbon (14C) determination. The timeliness of this project is fostered by the recent advances in 14C detection for measur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Coordinated Use of miniaturized Robotic equipment and advanced Sensors for search and rescue OpeRations' (CURSOR) targeting Horizon 2020.

assistant: **Abstract**

The CURSOR proposal aims at developing new and innovative ways of detecting victims under debris. This includes the coordinated use of miniaturized robotic equipment and advanced sensors for achieving significant improvements in search and rescue operations with respect to (a) the time used to detect trapped victims after a building structure has collapsed, and (b) an informed and accelerated decision making by first responders during rescue operations allowing for the deployment of expert personnel and, in particular for operations in hazardous environments, suitable equipment at prioritized locations.CURSOR is proposing a system consisting of several integrated technological components. It includes Unmanned Aerial Vehicles (UAVs) for command & control, 3D modelling and transportation of disposable miniaturized robots, that are equipped with advanced sensors for the sensitive detection of volatile chemical signatures of human beings. Information and data collected are transferred in real time to a handheld device operated by first responders at the disaster site.


**Keywords:** USAR, search and rescue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Neural-based solution to boost drug preclinical research success' (MolPredict) targeting Horizon 2020.

assistant: **Abstract**

The competitiveness of the R&D process in this industry has been steadily declining during the past two decades. Whereas in 2000 the average cost for developing a new drug was close to €1 billion, in 2015 the estimated cost was €2.58 billion, a 150% increase. Consequently, the different actors of the pharmaceutical R&D industry have an urgent need to improve their effectiveness to develop new drugs. In this sense, the early stage of the R&D process shows the greatest potential to increase the success rate of new drug candidates, as it is in this phase where candidate molecules are selected for further testing in humans. Computer Aided Drug Design (CADD) is the most cost-effective tool for drug discovery. These technologies allow researchers to screen large databases of molecules and simulate its interaction in vivo. However, they are extremely intensive in computational resources. As a result, existing solutions have to implement simplifications in the simulations in order to incur acceptable computational times. These simplifications come at the cost of accuracy, finding a low rate of bioactive molecules that, in addition, usually fail during clinical trials. Pharmacelera aims at creating a new computing standard for Computer-Aided Drug Design (CADD) through an open machine learning platform that enables accurate prediction of molecular properties of candidate molecules based on quantum-mechanics (QM) calculations during drug development. By providing early stage ADME-Tox analysis, thus dramatically reducing the failure rate of the drug design process. In addition, by combining HPC, new disruptive molecular modelling techniques (computational chemistry) and machine learning, PharmAgile will be 20x faster and 10x more precise than any existing solution.   Consequently,