RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Diamond Quantum Devices and Biology' (BIOQ).

assistant: **Concept**

Many of the most remarkable contributions of modern science to society have arisen from interdisciplinary work of scientists enabling novel imaging and sensing technologies (NMR, X-ray diffraction, electron microscopy). BioQ will revolutionize the state of the art to create novel sensing technologies for the broad field of life sciences research that provide unprecedented access and insight into structure and function of individual bio-molecules under physiological conditions and apply these to the observation of biological processes down to the quantum level and with atomic resolution. At this level quantum properties are predicted to play an important role for the function of biological systems subject to environmental noise. BioQ will unravel the interplay of quantum coherent dynamics, molecular vibrations and environmental noise due to molecular vibrations in biological processes and design and carry out experimental tests of its predictions. BioQ will achieve new levels of understanding and control of biological systems, culminating in new ways to interface biological systems with quantum devices. To this end BioQ will exploit the ability of biological systems to arrange themselves into highly ordered structures to form novel hybrid materials of functionalized nano-diamonds that are capable of harnessing complex quantum dynamics at room temperature.A deeper understanding of biological processes will open new roads towards drug design and bio-imaging. The elucidation of energy transport processes and dynamics may pave the way towards the design of more efficient light harvesting systems. Self-assembled hybrid bio-quantum devices provide a novel perspective towards quantum nanotechnology. The broad challenges that this ambitious programme present will be solved by an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Integrated Services to Boost Energy Renovation in Hungarian Homes'.

assistant: **Objectives**

RenoHUb aims to trigger a significant upscale of the energy retrofits of the Hungarian homes through the development of an integrated business model that is sustainable and cost-covering after the end of the project. RenoHUb intends to enable households to take the first step towards becoming prosumers, and map and remove all the non-financial barriers which cause setbacks in the process.The project addresses the entire value chain of home retrofit: from social, behavioral, communication and capacity building aspects through supporting the decision-making and the technical implementation, up to ex-post assessment of energy and cost saving. The key project focus includes the promotion of trilateral cooperation between the home owners, the existing local “Sparkasse” (building saving society) institutions as well as commercial and development banks.The total of 4.4 million of Hungarian households accounts for some 33-35 percent of the country's energy consumption. Two-thirds of residential building stock is energetically outdated. Hungary’s final energy saving commitment by the end of 2020 assumes 167,5 PJ. With the current pace of the energy refurbishment in the residential sector, this target is unlikely to be achieved. The goals for 2030 have already been drafted in the National Energy and Climate Plan (NECP) and will be decided by the end of 2019. The residential sector will be the primary sector targeted for energy efficiency developments since after demonstrating a slight decline within the period of 2005-2015 the overall energy consumption of the residential sector has increased since 2015.RenoHUb encompasses extensive consultations with stakeholders, including financing institutions, as well as capacity building, pilot renovation activities and targeted communicati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ultrafast Picoscopy of Solids' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Material science, quantum chemistry, electrical and quantum engineering in the 21st century focus on manipulating and harnessing the properties of matter at the level of atoms and electrons. Advancing these technological capabilities to their ultimate limit calls for novel imaging techniques that can allow us to peer into matter at the level of valence electrons and follow their dynamics in space (tens of picometers) and time (femtosecond to attoseconds).  Here we propose the development and use of ultrafast picoscopy to attain this grand goal of ultrafast and microscopy sciences. Intense laser fields can drive the coherent motion of electrons inside crystals to emit high harmonics of the fundamental whose spectral characteristics embody critical information about the spatial arrangement of electrons and atoms in the sub-angstrom scale. By combining this capability with state-of-the-art laser pulses whose field waveform is confined to a fraction of a femtosecond (optical attosecond pulses), it should be possible to record movies of electrons in solids in picometer space and attosecond time scales. Ultrafast picoscopy aims at enabling the three-dimensional visualization of the chemical bond in condensed matter, the detailed visualization of structural changes in crystalline materials and the real-time tracking of atomic and electron motion in ordinary and correlated materials.  We anticipate the technique and the results of this endeavour to yield benefits to a broad range of scientific disciplines ranging from physics and quantum chemistry to material science and information technology.


**Keywords:** Attosecond physics, nonlinear optics, high harmonic generation in solids, strong field physics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'BUILDING THE GREEN WAY: WIDE TAKE-UP OF A VERSATILE, PROVEN, ENERGY AND COST EFFICIENT INSULATION TECHNOLOGY' (INSUPanel).

assistant: **Concept**

INSUPanel  offers non-structural lightweight wall panels of precast concrete adjoined to each other creating a perfect seal of great durability, forming a zero-energy inspired building envelope when insulation materials are faced with the panels. INSUPanel building solution is a 100% thermal bridge free technology (ca. 32% and 94% more energy efficient than current insulated walls and typical brick walls, respectively)  capable of eliminating thermal bridges (reaching a very low U-value of 0.121W/m2K vs. 0.18W/m2K of current insulated walls or 2.0W/m2K of typical brick walls), thus, improving energy efficiency, increasing comfort in dwellings, and reducing drastically building construction times and costs. Panels are prefabricated and lightweight so they can be placed directly withouth the use of scaffolding.  Our company, Construcciones Zorzano is a renowned construction firm with 25+ year experience in differing areas of construction as a promoter, construction, and real state company (more than 1,000 dwellings built in Spain). Zorzano has developed INSUPanel in response to market feedback to reduce energy consumption in buildings (in EU heating & cooling account for 36% of CO2 emissions and 12% of total energy consumption) and due to stringent EU regulations pushing towards the delivery of nearly zero energy buildings (nZEBs) by 2019 and 2021 for public and private buildings, respectively. We plan to penetrate the energy efficiency building sector for residential and non-residential constructions in EU countries leaders in construction growth output: 1) in early 2020, Spain and France, 2) followed in 2021 by Germany, UK, and Italy, and 3) by 2022 and beyond, expand sales to Belgium, the Netherlands, Eastern Europe, Russia, and the US, beginning with new builds and af
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'IMPLEMENTATION OF AN INNOVATIVE COGENERATION SCHEME INTEGRATING A NOVEL PARTIAL OXIDATION GAS TURBINE : OXI-COGEN' to be submitted under Fourth Framework.

assistant: **Abstract**

The aim of the project is to achieve the first industrial realisation of a new solution for high temperature cogeneration by implementing a partial oxidation gas turbine scheme, called here Oxipar turbine in the cogeneration scheme.The partial oxidation gas turbine is to be installed parallel with an adapted 'base' gas turbine. This innovative alternative can be used to upgrade the efficiency of an existing natural gas fired boiler, or of an existing gas turbine based cogen installation.The aim is to improve the fuel efficiency through the addition of the Oxipar cycle power output to the base gas turbine power, and calibrating the cogeneration system to the base steam load of the industrial site.In this new high temperature cogeneration scheme the electrical efficiency is increased from 18.4% (conventional gas turbine + post combustion) to 20.7% for the same 80% global thermal efficiency.1.Innovative technologyThe innovative plant comprises three main elements :- The base gas turbine, ranked to 6 MW, provides electrical output, hot exhaust oxidizing gases to the burner of the boiler and about 1 kg/s of compressed air bleed to the Oxipar gas turbine.- The Oxipar gas turbine, ranked to 1 MW, is fed with compressed air from the base gas turbine, steam from the boiler and natural gas.It exhausts a combustible gas into a power turbine driving an electrical generator and then into the burner of the boiler. The fired medium temperature boiler, that uses the hot exhaust gases from both gas turbines in a specially designed burner. 2. Context :High temperature (HT) cogeneration (where heat has to be delivered at HT, say above 600°C) is a field where according to a recent study financed by the CEE there is need for new technologies.3. Economic aspects : Expected costs per KW insta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Presynaptic Regulatory Principles in Synaptic Plasticity, Neuronal Network Function, and Behaviour' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Neuronal signalling via synaptic vesicle (SV) fusion is the fastest membrane fusion event in mammalian cells. Its speed and the ability of presynapses to sustain SV fusion at high stimulation rates are key requirements for brain function. Plastic changes of SV fusion rates have long been thought to control complex brain processes such as working memory, but the link between presynaptic plasticity and complex brain functions remains hypothetical. A key determinant of presynaptic efficacy is that synapses maintain a release-ready or primed SV pool that can be refilled rapidly. SV priming is mediated by a set of dedicated priming proteins (Munc13s, CAPSs, and accessory proteins), which are of pervasive and essential functional importance for synaptic efficacy, and - based on in vitro studies - of capacious potential to regulate exactly the type of synaptic plasticity that is associated with brain circuit characteristics involved in complex behaviours. However, this 'catholic' role of the SV priming machinery in brain function has never been tested, mainly because essential genetic models for studies in vivo have been lacking. Using (i) 4 newly generated conditional KO and KI mouse lines, (ii) 17 additional KOs/KIs (12 ours), (iii) high-end EM approaches (iv) KO-replacement strategies, (v) electrophysiological and optophysiological analyses, and (vi) behavioural studies, we will examine the SV priming machinery in intact circuits in order to (a) define the mechanisms and cell biological basis of SV priming, of its dynamics, and of defined priming-dependent synaptic plasticity states, and to (b) define the causal links between SV priming, synapse function, synaptic plasticity, circuit characteristics, and behaviour. These studies will generate a comprehensive delineation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Methodology, Analysis and eXperiments for the ""Safety In MYRRHA Assessment""""' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The Strategic Research Agenda of the EU Sustainable Nuclear Energy Technical platform requires new large infrastructures for its successful deployment. MYRRHA has been identified as a long term supporting research facility for all ESNII systems and as such put in the high-priority list of ESFRI. The goal of MAXSIMA is to contribute to the ""safety in MYRRHA"" assessment.MAXSIMA has five technical work-packages. The first contains safety analyses to support licensing of MYRRHA. Design-based, design extended and severe accident events will be studied with a focus on transients potentially leading to fuel pin failures. Fuel assembly blockage and control system failure are the least unlikely events leading to core damage. For code validation a thermal-hydraulic study of different blockage scenarios of the fuel bundle and tests of the hydrodynamic behaviour of a new buoyancy driven control/safety system are planned. Both are supported by numerical simulations. Safety of the Steam Generator is treated by looking at consequences and damage propagation of a SG Tube Rupture event (SGTR) and by characterising leak rates and bubble sizes from typical cracks in a SGTR. Additionally a leak detection system and the drag on bubbles travelling through liquid LBE are studied. MOX fuel segment qualification with transient irradiations is a big step in licensing. MAXIMA include validation experiments for safety computer codes involving core damage scenarios with high temperature MOX-LBE interactions. Fuel-coolant-clad chemistry is studied up to 1700°C and a core melt experiment in a reactor is prepared to assess the interaction of LBE with molten fuel. Following the Fukushima accident, effort is put on development of enhanced passive safety systems for decay heat removal and on confinemen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Automatic Procedure to Manufacture Individual Implants-Custom Made Prosthesis-Operation Stencils Based on Computed Tomography Data' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The objective of the programme is the development of an automatic low-cost processing to manufacture individual implants as well as custom made prostheses and operation stencils based on computed tomography data. A geometrically precise model can be designed on the basis of computed tomography scans. The model is manufactured with CAD/CAM systems. Due to these developments, industrial enterprises will be able to cover the medical demands for low-cost individual implants and thus serve an important and growing market in the medical field. Principally, the medically required precision of individual implants cannot be met with conventional technologies. These cannot convert the computed tomography data to a geometrically precise model. The processing-chain: DATA ACQUISITION - IMAGE PROCESSING - GEOMETRY PROCESSING - MANUFACTURING - SURGICAL PLANNING AIDS must be defined and co-ordinated with medical results. For an efficient processing, the single steps need to be mechanized. This development will be distributed together with a flow chart and guidelines concerning the processing-chain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Deacetylase inhibitors for autism spectrum disorders: an integrated preclinical validation pipeline in brain organoids and in vivo models' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

ASD is a very prevalent neurodevelopmental condition affecting more than 1% individuals, and represents a major unmet medical need since no effective treatment is available. Despite the phenotypic convergence of its core symptoms (impaired language, restriction in sociability and stereotypies, invariably coupled to anxiety and often associated to varying degrees of intellectual disability), ASD is genetically highly heterogeneous, with hundreds of bona fide causative genetic lesions. This genetic architecture breaks down ASD into a collection of rare and highly penetrant genetic syndromes, presenting key challenges but also decisive applicative opportunities: i) the accelerated regulatory path for drug approval/repurposing; and ii) the possibility that few paradigmatic syndromes may yield generalizable therapeutic inroads for ASD treatment. Duplication at 7q11.23 (7Dup), encompassing 26-28 genes, is one of best characterized ASD-causing copy number variations and offers unique translational opportunities, also because hemydeletion of the same interval causes Williams-Beuren syndrome, a condition characterized by hypersociability and language strengths, thereby providing a unique reference standard to validate treatments for the core ASD symptoms. Within my ERC-Consolidator project we successfully completed a high-throughput screening on 7q11.23 CNV patient-derived neurons and discovered that deacetylase inhibition lowers the abnormal levels of a key gene underlying the cognitive/behavioral traits of 7Dup. Having defined robust 7Dup neurodevelopmental and electrophysiological phenotypes, both in patients’ neuronal lineages and in mouse models, we now aim to generate proof of concept for the preclinical validation of selected deacetylase inhibitors in rescuing ASD phenoty
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Genomic HIV-1 vaccine trial' to be submitted under Fourth Framework.

assistant: **Abstract**

We intend to carry out a demonstration project with three genetic vaccines that will induce a cellular immune response towards HIV-l regulatory proteins. The prototype vaccines, tested earlier for safety and immunogenicity in small animals and in non-human primates, will be given firstly to HIV-l infected individuals known to lack pre-immunization responses to HIV-l Nef, Tat and Rev and secondly to noninfected individuals at risk for HIV infection. The objective of this project is to show, that the prototype vaccines can be economically produced under GMP conditions and that the vaccines are safe, immunogenic and have a beneficial therapeutic effect in the HIV infected individuals. Preparation of the prototype vaccines. Three eukaryotic DNA vectors, a non-replicating (pHCMV), another one with limited self-replicative capacity (pBamNeo) and a non-replicating vaccinia virus (MVA) have been developed to express single HIV genes (nef. tat or rev). The capacity of these delivery systems has been evaluated for protein expression in-vitro and for immunogenicity and safety in-vivo in experimental animals and for one of the vectors, in human volunteers. The plasmid DNAs will be prepared under GMP conditions by one of the SME partners, SBL vaccine and tested for CQ. Human studies: The demonstration study (a pilot type investigation) will be performed in voluntary HIV-infected asymptomatic individuals. For each of the three immunogenic gene constructs (HIV nef, tat or rev), 20 patients/center will be immunized in Munich, Stockholm and Tampere, using one of the three expression systems. Furthermore, 29 high-risk but non-infected sexual partners to HIV-1 infected patients will be vaccinated with a combination of vectors expressing all three proteins. Thus, altogether 60 immunized HI