RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular and evolutionary characterization of core and linker histone variants: mechanisms involved in altered chromatin conformations arising from pathological states', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

In eukaryotes the avaliability of the genetic information stored in the DNA is modulated by the interactions of this molecule with a broad spectrum of nuclear proteins such as histones and non-histone proteins. Histones are the main protein components of t he chromatin, where core histones organize DNA into nucleosome core particles and the linker histones bind to the regions contacting adjacent nucleosomes in the chromatin fiber. Although there has recently been a renewed interest in the functional and stru ctural characterization of histone variants, their role in the modulation of chromatin folding and dynamics is poorly understood. Histones H2A and H1 are characteristic for presenting the widest variability of variants among histones, including roles relat ed to DNA double-strand breaks repair, cell cycle checkpoints, and tumor supression. The present project represents a very innovative, high quality and multidisciplinary scientific work whose aim is to develop a molecular and evolutionary analysis of diffe rent core and linker histone proteins. The objetives proposed are: 1) the isolation and characterization of core and linker histone variants in vertebrate and protozoan lineages, 2) the molecular evolutionary analysis of core and linker histone variants to wards their functional diversification related to different chromatin structures, 3) the structural and functional characterization of chromatin complexes reconstituted from core histone variants including H2A.X and H2A.Z and further characterization of th e interactions of linker histones with chromatin. The analysis of such protein structures and the functional consequences of their modes of interaction with DNA will allow us to establish links with mechanisms involved in the altered chromatin conformation s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CARe in an INterGenerational context How do changes in family formation trajectories reflect in later intergenerational relations? A three-generations perspective' (CARING).

assistant: **Innovation**

How do changes in early family formation trajectories reflect on later intergenerational relations and care support across generations? Early life choices in the process of family formation reflect in the availability of later potential for care giving, or demands for it. CARING investigates the contribution of early family formation trajectories on explaining differences in intergenerational relations and support patterns later in life. Country differences in the demography of family-linked life stages, and how these reflect on caring responsibilities, have remained largely unexplored. But the timing of family formation and dissolution, childbirth and grand-parenting are key transitions with bearing on entitlements and obligations to inter-household (reciprocal) solidarity and support. To address these issues CARING will explore the effects of family diversification (childlessness, union dissolution and fertility postponement) on intergenerational relations and support in 5 selected countries: Italy, Germany, France, Denmark and Czech Republic. Sequence analysis on data from SHARE surveys will compare family trajectories (partnerships and fertility over 34 years, at ages 16-49) for individuals from the birth cohorts 1927-56. Family formation trajectories will contribute to the study of: current patterns of relations, upward support and downward support through hierarchical multinomial logit models. Results will be validated on fertility trajectories for larger sample sizes and younger birth cohorts (1957-64). The project will adopt a comparative multi-generational perspective with a focus on three generations, helping shed light on the ‘caring potential’ for the new generations, experiencing longer and thinner (beanpole) families and increasing rates of childlessness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design of an innovative system for the drive and control of port cranes for safe remote operation' (SECURCRANE) targeting Sixth Framework.

assistant: **Abstract**

SECURCRANE project is addressed to the toll lifting equipments of the ports for a great increaseof their performances, safety and operator comfort. Crane drivers & port managers are key actors deeply involved since the very beginning to set out the right terms for future implementation. The goal is to practically eliminate the gap between the theoretical and the real productivity (lifts per hour) of the crane. In this field, because of the highly detailed bids from the buyers and the severe price competition, manufacturers neglect the risks for research & innovation. The core problem of the crane productivity is related to the loss of efficiencyof the crane operator due to his very stress while working in the crane cabin. The stress comes from the cabin rough vibrations and from the frustrating continuous attention to the cargo sway during the load cycle. SECURCRANE project aims at realising the ambitious goal of a remote crane control giving the operator, by means of a very innovative approach and the most advanced knowledge in the field of artificial intelligence and artificial vision, the information sensed" and seen by the operator in his position onboard. The functions of the remote control are completed by a further objective i.e. the container monitoring for integrity and safety. The project cares even the social aspects of the innovation, involving the crane drivers from the early beginning of activities. SECURCRANE Consortium, formed under port operators' solicitation,is formed by Research bodies and specialised Company for robotics coordinated by an Engineering company with keypersons having huge experience in the port technologies field. The Consortium is completed by a Port Authority for onboard tests and a SECURCRANE INTEREST OPERATORS CLUB (SIOC) of potent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cell signaling during differentiation in drosophila' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

In the last few years a large amount of work has focused on the role of cell signalling in the assignation of cell fates. However, the switches and events that lead cells to differentiate have remained relatively unexplored.The present proposal deals with the role that a central signalling pathway, the ras pathway, plays in cell differentiation. I plan to study this in the fruit fly Drosophila melanogaster by focusing on one decision: the commitment of particular cells to differentiate as sensory organs of the peripheral nervous system, and the role of one particular class of enzymes: the MAPkinases, in this event. This will allow me to use the powerful Genetics characteristic of the fruit fly and combine this with my more biochemical background, to make up a multidisciplinary approach to this problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Electrochemically-enabled high-throughput peptidomics for next-generation precision medicine'.

assistant: **Objectives**

The uptake of proteomics for precision or personalised medicine applications requires the development of an effective screening instrument capable of detecting proteins at the low concentrations they are found in biological conditions while addressing their large chemical variability. The ElectroMed project's objective is to build and validate a proof-of-concept prototype of a programmable high-throughput peptide microarray technology. It is based on the radical vision of integrating electrochemical synthesis of peptide bioreceptors to enable programmable in situ protein detection with nano-functionalised FinFET sensors for high-performance data acquisition within a microfluidic-driven multiplexed platform for parallel screening. The project will undertake the research and innovation work required to 1) demonstrate multiplexed electrochemical peptide synthesis (EPS), 2) develop new FinFET sensors and 3) integrate EPS and the FinFET sensors in a single cost-effective prototype that we will validate in laboratory-relevant conditions.The ElectroMed project will achieve a technology breakthrough of the first fully-programmable in situ protein screening instrument. This prototype small-size single instrument will come as a faster, cheaper, and more efficient technology than current protein screening instruments. The potential impact is to significantly ease and reduce the price of protein screening to trigger an uptake of protein detection in healthcare (our primary focus) as well as in the food sector (food authenticity and traceability, allergens, GMOs or toxins detection all along food the value chain), environmental remediation or defense (detection of biological warfare agents).Electromed has also engaged to investigate COVID19 related peptide biomarkers and technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A novel reliable diagnostic device to avoid unnecessary thyroid surgery' (ThyroTrust).

assistant: **Concept**

Fine needle aspiration cytology (FNAC) is the best procedure for a timely and reliable diagnosis of either a benign or malignant thyroid lesion. However, the management of patients with indeterminate cytology (10-26%) is a frequent clinical and social problem, as this cytological category is associated with a 15 to 30% prevalence of malignancy, forcing most of these patients to diagnostic surgery. However, for the 80% of these patients the surgery is unnecessary as the postoperative histology reveal a benign lesion. The negative social and financial consequences of this approach are relevant in Europe (44000/year thyroidectomy only in Italy) as well as the adverse influences on the quality of life of the patients due to surgical complications and hormone replacement. We will introduce in the market the first clinically validated CE-IVD targeted Next Generation Sequencing diagnostic kit ThyroTrust for the correct diagnosis of thyroid nodules with indeterminate cytology.   Our kit is the first to include a considerable number of variations in 47 genes, 66 types of rearrangements and 8 gene expression level measured at the same time and associated with malignant outcome. This will avoid diagnostic surgery if a risk of malignancy <5%. In the scope of the feasibility study we will assess: - Technology innovation opportunity and business idea - Development planning and partner search - IPR, quality, organization and manufacturing route - GO-TO-MARKET strategy and business plan  740,000 FNA are performed in Europe, so the addressable market, with an end-user price/kit of 300€, is over €50 Million/year. Prudentially, market estimation considers only FNA results classified as “indeterminate cytology”. The same approach could be evaluated and adopted for other cancer diagnostics,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Performance management of commercial parallel database systems' under Fourth Framework.

assistant: **Concept**

The objective of the project is to promote the wider use of parallel database systems by helping the user to visualise and understand the way workloads are handled by particular parallel systems and configurations.The project will develop tools to analyse performance and thereby aid the sizing and configuration of commercial systems. These tools will predict the performance of a particular configuration under a specific workload, analyse and display information to highlight bottlenecks and assist the tuning of a particular configuration for a specific workload. The tools to be developed encapsulate knowledge about the database management system and parallel platform to be analysed. These tools will initially support models of the GoldRush, SP2 and nCUBE parallel machines and of the ORACLE and INFORMIX database management systems. A common and easily-used graphical will be developed which will help determine the most efficient overall configuration. This will also provide support for the calibration and validation of the tools which will be done by reference to real commercial workloads giving the project feedback on the applicability of its developments. Results from the project will be used initially by the partners in their daily business.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Hybrid ultra-precision manufacturing process based on positional- and self-assembly for complex micro-products'.

assistant: **Concept**

Today, emerging highly complex micro-devices with applications in mechanics, electronics, biological engineering, microfluidics and IT request ultra precision manufacturing processes. HYDROMEL's first objective is to develop the tomorrow's high precision flexible and cost-effective manufacturing process for complex micro-products including emerging products that cannot be synthesised through one-shot processes. HYDROMEL will aim at developing a new versatile 3D automated production system with a positioning accuracy of 100 nm for complex micro-devices. Based on ultra precision robots improved by the innovative knowledge-based self-assembly technology, this groundbreaking combination will participate in the massive production of high-added value strategic and emerging micro-products.The combination of positional assembly - where objects are mechanically manipulated and positioned one by one - and self-assembly -where objects arrange themselves into ordered structures by physical or chemical interactions- has never been achieved at the industrial scale and, as a consequence, will be a new and flexible production concept permitting the development of a fully innovating hybrid automated tool for assembly of micro-products. Relying on the latest scientific developments in robotics and self-assembly, HYDROMEL's academic and R&D partners will make possible the availability of a hybrid/self-assembly technology in Europe at an industrial scale, which will be radically new and will push Europe as leader in the field of high added value micro-products manufacturing. Thanks to the flexibility of the process, HYDROMEL will be capable of meeting requirements in wide range of applications and, as a consequence, dynamize existing markets and open new ones to generate employment. Increa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'SMART BIOHYBRID PHYTO-ORGANISMS FOR ENVIRONMENTAL IN SITU MONITORING'.

assistant: **Concept**

WatchPlant will develop a new biohybrid system technology, a wireless wearable self-powered sensor for in-situ monitoring of urban environments. This system equips urban biological organisms -plants- with Artificial Intelligence (AI) to create a smart sensor for measuring both, environmental parameters and the responding physiological state of plants, in a very early stage by the use of a barely explored fluid, phloem sap, in combination with chemical, and physical sensors. It will be integrated into complex network that allows performing distributed information processing, decision making, modeling and data fitting, paving the way for the self-awareness or self-adaptation. Additionally, it will constitute a clean energy self-powered device due to the novel use of sap, not only for transforming plants into living sensors, but also for clean energy generation.A consortium of EU research, technology centers and ambitious high-tech SMEs will stretch and combine the limits of plant physiology and bioelectronics with microtechnology, multiphysics modelling, sensor engineering, AI and environmental modelling, to transform plant into living autonomous and self-powered sensors. The project has the ambition to solve how to extract sufficient sap volume in a healthy plant, how to make long-lasting bioelectronics, and how create a smart self-powered wearable phytosensor in a single device. It also has the challenge of modelling urban environments using novel combinations of exiting parameters and explores the future role of sap in this sense. Thus, it is a promising tool to carry out weather/pollution/pandemics development forecasting systems up to social networks for proving an ecological/environmental feedback to citizens. Thus it will be possible to perform specific actions and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Next-generation vaccines and diagnostics to prevent livestock reproductive diseases of worldwide impact' (REPRODIVAC).

assistant: **Concept**

Endemic and zoonotic infectious reproductive diseases of livestock cause major economic losses globally and threaten both food security and public health. REPRODIVAC will develop new and improved vaccines and diagnostic tools required to better control four priority abortifacient diseases: porcine reproductive and respiratory syndrome (PRRS), Q fever, ovine enzootic abortion (OEA), and porcine brucellosis. The consortium spans academia and industry with complementary expertise including structural biology, microbiology, immunology, plant and veterinary sciences. This enables us to address reproductive disorders with an interdisciplinary approach: (1) applying reverse and structural vaccinology to select and design vaccine and diagnostic candidate antigens; (2) exploiting relevant protein expression systems for the production of these antigens; (3) producing rationally attenuated and viral vectored vaccines; and (4) developing a suite of molecular and immunological diagnostic tests, including  point-of-care tests (PoC) to discriminate vaccinated from infected animals (DIVA). We will develop a broadly protective PRRSV vaccine, and a serological ELISA that will reliably correlate with PRRSV neutralising antibody titres. We will identify protective subunit vaccine candidates for Q fever and validate a companion serological DIVA test. We will further refine an OEA vaccine for commercialisation and pursue a complementary approach towards a DIVA-compatible next-generation subunit vaccine and serological and molecular DIVA/PoC tests. We will develop live attenuated Brucella suis vaccines and brucellosis diagnostic tests with improved specificity. These new vaccines and diagnostics will be further developed by our industrial partners and made accessible to users. Thereby by usin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative eco-friendly crosslinker for leather and textile finishing' under Horizon 2020.

assistant: **Concept**

Green-Linker is a crosslinker, a type of chemical product used by tanneries in the leather sector and dyers in the textile sector as a finishing agent. The ranges of chemicals used today are often toxic and potentially harmful to the environment. Tanneries and textile dyers are looking for cost-effective and eco-friendly solutions that would allow them to comply with stringent regulations on harmful chemicals, and with the strong request by consumers of environmentally sustainable leather garments and accessories. The market for leather and textile chemicals is projected to grow steadily (4% CAGR) until 2024 following these market trends.Current crosslinkers in the market cover only partially client’s needs since they have limitations in terms of quality, toxicity and environmental sustainability. Italkem has developed, in a single product, an innovative crosslinker with superior characteristics. Green-Linker offers technical, environmental, and economic advantages over its competitors. Green-Linker results as the best performing in terms of highest temperature tolerance, fastest reaction time and longest pot-life, and colour fastness while its eco-friendliness level equals the best option in the market. Green-Linker meets the severe constraints imposed on the environment and toxicity of chemicals, being the ideal candidate to be recognized with Eco-Label as a sustainable and green product. In addition, its competitive price (37% saving respect the highest technical performance) is strongly supported by an improved storability, transport and logistic capacity.From Italkem we have been trading since 2002 serving global markets from Italy. We plan to introduce this novel product in the market after final validation with industrial end users and up-scaling production. This