RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Social Science Genetics Network' (ESSGN).

assistant: **Concept**

The European Social Science Genetics Network (ESSGN) brings together seven academic beneficiaries with a shared interest in social science genetics, i.e., in incorporating genetic information to improve our understanding of age-old questions in the social sciences, such as the origins of inequality, the ‘nature versus nurture’ debate, and the extent to which the interplay between environments and genes is important in shaping individuals’ lives. The consortium consists of an interdisciplinary group of academics, as well as seven non-academic partners committed to using data science to address inequalities in life chances. There is an urgent need for training in social science genetics due to recent technological advances in genetics, the intricacies of using genetic data, and the growing availability of such data in surveys traditionally studied by social scientists. Our aim is to train the next generation of social scientists in the responsible and technically correct use of genetic data and in objective communication about what can and cannot be learned from working with genetic data in the social sciences. The project will go beyond the state-of-the-art (i) by using Europe’s most comprehensive multigenerational databases to separate direct genetic effects from parental genetic and socio-economic factors that shape the rearing environment; and (ii) by exploiting the large toolbox of causal inference methods used in econometrics and statistics to estimate the extent to which environments causally protect individuals with genetic disadvantages. We will (1) analyse to what extent genetic (‘nature’) and environmental (‘nurture’) factors contribute to equality of opportunity and intergenerational mobility, and (2) establish how nature and nurture jointly shape inequalities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enlarging the Glycosynthase Methodology' (EGLYM).

assistant: **Concept**

Since the initial development of the glycosynthase methodology, progress has been mainly focused on beta-glycosidic bond formation with neutral hexosyl units to produce simple oligo- and polysaccharides. We propose to give a step further by i) enriching the range of catalysts available towards specific psychrophilic activities, and ii) extending the methodology towards in vitro synthesis of anionic polysaccharides for the development of novel biomaterials.Glycosynthases are mutant glycosidases with a non-nucleophilic amino acid replacing the catalytic nucleophile. They are hydrolytically inactive, but, when presented with an activated donor sugar, condense the donor and an acceptor sugar in high yield. The usual Â-glycosyl fluoride donor is labile at high temperature and is readily hydrolysed above 50ºC. Therefore, the temperature used for the glycosynthase reaction is a compromise between donor stability and enzyme activity that renders conditions far from optimal. Thus, being able to perform the glycosynthase reaction at low temperature will clearly enhance product yields. Screening for cold glycosidase activities in psychrophilic bacteria and cloning of the corresponding genes will provide the necessary enzymatic toolbox.Another challenge is to extend the possibilities for the synthesis of original oligosaccharides. In the frame of this project, we plan to address the synthesis of glycosaminoglycans (GAGs), current targets in biomedical applications. GAGs are a large family of anionic polysaccharides with disaccharide repeating units of uronic acid and hexosamine. Engineering and directed evolution will be performed on existing beta-glucanases or beta-glucosidases to accept charged donors. The proposed project will combine an existing repertoire of characterized glyc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Total Synthesis of (2R)-Hydroxy-Norneomajucin and Biological Evaluation of Neurite Outgrowth' under Seventh Framework.

assistant: **Concept**

Over the past century, there has been a worldwide escalation in the prevalence of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and Huntington’s disease. There are still no cures for these disorders and current therapeutics are only palliative. More recently, emerging therapeutic approaches have focused on maintaining neuronal function in these disease models with small molecules that possess neurotrophic properties. In this multidisciplinary proposal, we plan to complete the first total synthesis of (2R)-hydroxy-norneomajucin, confirm the neurotrophic activity of this natural product and evaluate advanced intermediates, and also initiate investigations into the biological target of this compound. The key transformation of our synthetic approach involves a Transannular Diels–Alder (TADA) reaction to establish the ABC ring system of the molecule in a single step. Assembly of the Diels-Alder precursor will be achieved through the combination of four basic fragments utilizing a Yamaguchi macrolactonization, Pd-mediated coupling, Horner-Wadsworth-Emmons olefination and an alkylation. All synthetic work will be performed at the host institution (Gademann Lab, University of Basel, Switzerland). With (2R)-hydroxy-norneomajucin and analogs in hand, we then plan to perform a NGF-mediated neurite outgrowth PC-12 cellular assay on the natural product and advanced intermediates at the host institution (Gademann Lab, University of Basel, Switzerland). In addition, we plan to perform HIP-HOP assays to elucidate the biological target of this molecule in collaboration with Dominic Hoepfner (NIBR Novartis Basel). The latter collaborative project will help to establish a working partnership between academia and industry in Europe. In general, this multidisciplinary proposa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Impact of emotions on learning and memory-related brain processes across development: an application to climate-related educational issues' (Emotiv4climate).

assistant: **Concept**

Providing large-scale sustainability education programs, in particular regarding climate issues, is critical to quickly implement the profound socio-ecological transformations expected by the mid-21st century. Although climate awareness is growing, current education policies -which mainly warn the risks of climate change, therefore focusing on negative contents- struggle to reach their objectives, as misinformation and poor knowledge assimilation persist. Yet, recent advances in neurosciences suggest that while negative emotion strengthen the memory of the emotional element, it disrupts associative memory, which is essential for the development of complex multivariate representations. Leveraging cutting-edge neurophysiological techniques (magnetoencephalography, electroencephalography), Emotiv4climate hypothesizes that positive emotions will enhance associative memory due to the selective integration of the newly learned information within hippocampus-dependent networks that promote their binding. And that positive memories will benefit more from sleep-dependent consolidation processes than negative ones, favouring their integration within pre-existing knowledge. Using ecology-themed material and questionnaires, Emotiv4climate will elucidate the differential impact of emotions (positive vs negative) on the behavioural and functional brain connectivity processes associated with learning and memory processes with an applied dimension to climate-related educational issues. Our understanding will benefit from a developmental approach comparing young adults and school-aged children with different maturational levels in terms of sleep-dependent memory consolidation processes. Emotiv4climate will hence not only uncover the cognitive and neurophysiological mechanisms through wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Trust Frame For Electronic Documents Exchange Between European Judicial Operators'.

assistant: **Objectives**

Civil procedural system for the resolution of conflicts, is by definition, a complex system, where several organizations interrelationed to each other take part, developing its activity following procedures very varied. Owing to the fact the judicial system has great secure and confidential requirements and procedures very established, always it has been very reluctant to the introduction of the new IST. The official communications between the Courts and the Attorneys and these with the Registrars, continuous being through certificated mail, and mainly, personally.This fact entails the following problems:- Slowness in the processes;- Possibility of mistakes and loss;- Lack of security;- responsibility identification and trust, as well as- historic registers maintenance and Task duplicity.These problems will increase when the constitution of the global market is real. At this moment, very near, the market between European countries will increase substantially. That will create a rise in the communication between European Mercantile and Land Registrars. Additionally, if a dynamic communication, between the European Judicial operators is the target, the adaptation of the regulation of each country to a European regulation and to the standards is a new problem that is necessary to resolve.The general objective is to speed up the procedures and to increase the effectiveness of the quality service that the judicial operators, specifically Registrars and Attorneys, render to the society, through the use of secure and confidential Internet communications. To achieve this general objective during this project there are going: to develop a Internet communication, secure, confidential, scalable and interoperable, between the Registrars and Attorneys into the methodology that is go
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Radio pulsars with LOFAR: a study of extreme physics laboratories' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

A radio pulsar is formed when the iron core of a massive star collapses in a supernova explosion. Due to their extreme compactness and supernuclear density radio pulsars are extremely stable rotators. Our goal is 1) to use radio pulsars to improve our limited understanding of some of the most energetic events known in the universe and the source of the elements that make up planets and all forms of life: supernovae 2) to find individual radio-pulsar systems that are such stable rotators that they can be used for the first-ever direct detection of gravitational waves or in the first ever strong-field test of gravity. We can do this with LOFAR, a revolutionary new radio telescope that host institute ASTRON is currently completing. LOFAR has more collecting by itself than all other radio telescopes in the world combined. In the course of his research in the US, van Leeuwen has acquired the radio-telescope survey experience, the instrument-development skills and the pulsar-population knowledge that will be needed for this project to push the boundary of our understanding of the universe. As the host institute is close to completing the most sensitive radio telescope in the world, the researcher will have unsurpassed means to accomplish the objectives laid out above. The host institute offers the researcher a tenure position in its scientific staff where he can be at the global forefront of telescope possibilities for the next decade. We expect to foster several intense decade-long EU-US co-operations between the host and the researcher's current US collaborators and Berkeley group to 1) adapt algorithms, monitor new discoveries and improve supernova modelling; and 2) design and build several leading-edge signal processing machines. For the next decade this project can defin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Solution attosecond chemistry' in the context of a Horizon Europe call.

assistant: **Objectives**

X-ray photons carry sufficient energy to interact with molecular core-shells electrons. Accessible for decades in the energy domain, the resulting core-excited states (CES) can now be observed in the time domain using attosecond (10-18 s) spectroscopy. These states are important as they govern the lineshapes in all x-ray spectroscopies. Here, we propose to first investigate and then manipulate the CES time evolution in solvated biomolecules in order to reveal key chemical information  i.e. solute-solvent interactions, local symmetries andchiral fields.CES lifetimes dictate the emission of secondary electrons active in radiotherapy. By observing the effect of solute-solvent interactions on CES we will be able to achieve a better understanding of the first molecular mechanisms of radiotherapy.CES are also a subtle probe of the absorbing atoms bonding environment. CES line splittings are lost in conventional x-ray spectroscopy due to homogenous broadening. We developed a technique based on the laser manipulation of CES capable of producing lineshapes up to an order of magnitude below the spectroscopys lifetime broadening and revealing core-level splitting. We will employ this approach to observe core-level splitting in solvated amino acids and metalloproteins and will use this new information to reveal the binding geometry of ligands with unprecedented accuracy.Finally, we will show how one can use nonlinear optics with attosecond pulses to reveal the chirality of the field surrounding sulphur and phosphorus atoms in biological samples. X-ray excitation localizes the point of view on the chiral field to a single atom. This perspective will allow us to examine the chiral landscape near the target atom. Here, chirality due to a single chiral centre will be probed in L-cystei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Home Care Activity Desk' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The objectives of the present proposal are the definition of a set of exercises to be used as a standard for home rehabilitation to be applied in the fields of occupational therapy and neurological rehabilitation (Stroke, TBI, Multiple Sclerosis and SCI patients). The definition of the above standards will generate information for the development of a low cost, user friendly activity desk that can be used by patients at home.The system will allow:- the execution of monitored exercises at home;- data recording during execution;- development of the patient database in order to evaluate patient recovery;- the development of an interactive database continuously updated that can be consulted by clinicians via Internet services.OBJECTIVESThe objectives of the present proposal are the definition of a set of exercises to be used as a standard for home rehabilitation in the fields of occupational therapy and neurological rehabilitation. The definition of the standards willable to develop a low cost-user friendly activity desk that can be used by patients at home. The system will allow: the execution of monitored exercises at home; data recording during execution; development of a database in order to evaluate patient recovery; the development of an interactive database that can be consulted by clinicians via Internet services. The Home Care Activity Desk, H-CAD, represents a bridge toward the patient of a data communication system that will allow: data monitoring (by wire or wireless); data archive management at the level of a central server; data display and analysis.DESCRIPTION OF WORKThe specific and technical objectives of the H-CAD project are planned to be achieved by employing the following workplan, which is broken down into 7Workpackages (WPs).WP1: State of the Art and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Cluster Observations and Theory Intersection: Providing selection functions and scaling relations to set constraints on the physics of the accelerating universe.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Astronomy is grappling with a profound issue: the origin of the accelerated expansion of the universe.  Is it caused by a mysterious dark energy, or a new aspect of the gravitational interaction? Galaxy clusters, the largest structures in the Universe, will help answer this question.  Cluster formation and evolution are driven by the evolution of the universe itself and cluster abundance is therefore a powerful observational tool that tightly constrains the cosmological model, such as dark energy, and key quantities of fundamental Physics, such as modifications to gravitational theory.  These constraints complement and strengthen those from other observational probes, such as type Ia supernova (SNIa), gravitational lensing and baryon acoustic oscillations (BAO). Critical aspects in the scientific analysis of cluster surveys are the survey selection function, relating the survey catalogue to the general cluster population, and the relation between the observable richness and cluster mass, the basic theoretical quantity. The establishment of these two elements is critically needed for the exploitation of optical/near-infrared imaging cluster surveys planned by the European scientific community. We propose to fill this need by 1) quantifying imaging survey cluster selection functions and 2) determining the form of the cluster richness-mass relation using a synergy between observations and well-behaved realistic mock catalogues; we will then 3) introduce this information into the Fisher Matrix formalism to predict possible constraints on theoretical models, e.g, the dark energy equation-of-state or modified gravity scenarios. The precision targeted by planned imaging surveys (e.g., Euclid, J-PAS, LSST, WFIRST) surpasses all previous analyses. Detailed evaluation of expected
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Promoting Positive Mental and Physical Health at Work in a Changing Environment: A Multi-level Approach' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Recent years have seen rapid changes in the workplace arising from the digital and green transitions (‘twin transition’), as well as the COVID-19 pandemic. New forms of work and work management have arisen, which can affect the physical and mental health of workers in new ways (both positive and negative) that are not yet well understood. Yet, workplaces can be health-promoting environments. Robust, comprehensive data must be generated, made available to key stakeholders, translated into evidence-based guidance to support the design of policies and used to develop evidence-based interventions and guidelines to promote mental and physical well-being and health in the workplace. PROSPERH will gather timely data and robust evidence on factors influencing mental and physical health in the workplace from the literature and analysis of existing high-quality datasets. Based on this evidence and building on existing EU-funded and national interventions, the project will develop and validate the multi-level PROSPERH intervention, delivered via the PROSPERH Portal. The intervention will target both organisational (work), peer and individual (worker) aspects, with three components focusing on health promotion, online self-monitoring & self-management and clinical care or coaching referral pathways. Development will focus on tailoring content for three sectors experiencing significant change (telework and ICT-based mobile work, health and construction), with validation carried out in 10 representative European countries and Australia through a cluster-randomised controlled trial to determine effectiveness and cost-effectiveness. To ensure that the expected impacts of PROSPERH are achieved during and beyond the project lifetime, key outputs of the project will include open access pu