RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Characterization of 7q11.23 reciprocal aneusomy syndromes: from patients to functional pathways (and back)'.

assistant: **Concept**

Technological advances have allowed the identification of multiple rare rearrangements caused by structural and copy number variants (CNVs). The 7q11.23 microduplication syndrome (7dup) and Williams-Beuren (WBS) syndromes are originated by genomic reciprocal rearrangements that result in opposite phenotypic features in the area of communication and sociability. Although WBS has been extensively studied, there is lack of exhaustive studies of 7dup at the clinical and molecular levels. In this project, we aim to compile and characterize a large group of 7dup patients. Moreover, we will actively collaborate with a recently created 7dup support group.Little is known about the functional mechanisms disrupted by these aneusomy syndromes and the specific alterations caused during brain development. Limitations in the available animal models, lack of quantitative data and limited computational capabilities have precluded the identification of relevant molecular pathways involved in these disorders. This proposal aims to overcome these limitations by applying an integrative multidisciplinary approach involving experimental and computational methods. To generate human neuronal in vitro models, somatic cells from a defined subset of individuals with 7dup and WBS will be reprogrammed to obtain induced pluripotent stem cells and differentiated to neurons. To define neuron-specific alteration patterns in gene expression caused by these CNVs we will perform transcriptome analyses at multiple differentiation stages. Finally, the expression data will be integrated with protein interaction and other systematic gene annotations datasets to perform omic analyses to identify dysregulated pathways.Our results will help to better characterize at clinical and molecular level the unexplored 7du
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'How is Populism and Health Associated in Europe (PHASE)? A multilevel analysis of the bi-directional interrelationship between populism and ill health' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The recent surge in populism marks a new phase of European politics posing fundamental challenges to scholars and the policy community. Some argue that existing nationalist and authoritarian attitudes are driving populism. Others posit that it is rooted in liberal institutions’ failure to deliver equal life chances. Once in power, populists tend to discriminate against precarious communities and question the role of expertise in governance. However, there is no systematic cross-country research on the bi-directional association between ill health and populism. The project contributes to the existing knowledge in two ways. Firstly, it crosscuts scholarly polarisations on the causes of populism by posing the original question of whether individuals’ health might be an early warning sign for the health of democracies in Europe. Secondly, it extends the literature on the impact of populist governance by asking who the winners and losers of populists in power in terms of health in Europe are. In answer to the first question, the project creates a longitudinal, hierarchical cross-country panel dataset, nesting individuals in EU regions, and measures the impact of ill health on populist support after 2000. In answer to the second question, the project adopts a coding scheme for populist governments in Europe and assesses the variegated impact of populism on peoples’ health using dynamic multilevel modelling. Finally, through a small-N case study, the project analyses the populism – ill health mechanism in detail. The project offers theoretically innovative and methodologically rigorous, cutting-edge contributions to sociology, political science, and public health, as well as to the public debate on populism through a set of outreach activities. The project will significantly e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Communications at the Synapse - a Near Atomic Resolution View into Cell-Cell Communication in the CNS' (CellCellEM) under Horizon 2020.

assistant: **Objectives**

Synapses are intercellular junctions specialized for coordinated cell-cell communication throughout the nervous system. They are organized by cell-adhesion molecules (CAMs) that bi-directionally orchestrate neuronal communication. Latrophilins (LPHNs) are a unique sub-family of CAMs that play critical roles in structuring the synaptic architecture through multifaceted interactions with a large variety of synaptic partners. Mutations in LPHN have been associated with neurodevelopmental and neuropsychiatric disorders. Despite their gravity, the mechanism governing LPHN synaptic activities remain elusive.To further our understanding of LPHN-mediated cell-cell communication, we suggest to characterize these receptors interactions with their intracellular and extracellular partners. For this purpose, we propose to adopt a hybrid approach driven primarily by cryo-EM, a state-of-the-art technique capable of dissecting the molecular mechanisms of super-molecular assemblies at extremely high spatial resolutions, which is our groups main field of expertise. The cryo-EM studies will be complemented by cryo electron tomography (cryo-ET), fluorescence microscopy and biochemical approaches. Our specific aims are:Aim 1: Dissect the molecular mechanisms of LPHN activation by combining cryo-EM with biochemical methodologies. Aim 2: Characterize the LPHN interactome through cryo-EM and fluorescence microscopy. Aim 3: Resolve the architecture of the LPHN interactome at a close-to-native environment through cryo-ET. Our experimental strategy will generate a quantitative, near-atomic resolution view of LPHNs and the mechanism by which they interact with their synaptic partners and instigate trans-synaptic signal transduction. These data will be vital for understanding LPHN-mediated cell-cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A general method for developing high-efficiency organic light-emitting diodes based on AIE-active room-temperature phosphorescent polymers' (AIE-RTP-PLED).

assistant: **Innovation**

Organic light-emitting diodes (OLEDs) as displays and luminaires have generated enormous attention because of their unique advantages compared to other lighting and display technologies. These include the capacity to fabricate ultra-thin, flexible and transparent devices that additionally have a much lower power consumption. Limited by the electron spin statistics, the maximum internal quantum efficiency (IQE) of conventional fluorescent OLEDs is only 25%. In contrast, thermally activated delayed fluorescence (TADF) can theoretically realize 100% IQE by recruiting triplet excitons and converting them into singlet excitons via reverse intersystem crossing. Most TADF materials must be doped into a rigid host matrix in order to suppress aggregation-caused quenching (ACQ) and other nonradiative processes. An alternative mechanism where 100% IQE can be realized is room temperature phosphorescence (RTP). This proposal targets the development of polymers that are both RTP and show aggregation induced emission (AIE). This permits these materials to be used as high-efficiency emitters in low-cost solution-processed OLEDs. Due to the synergistic effect of AIE, RTP, and polymer, high-efficiency RTP materials can be developed in the amorphous state, a previously undocumented advance in materials development. Through this research proposal, a general road map for simple and high-efficiency PLEDs will be constructed based on AIE-RTP polymers.


**Keywords:** Aggregation-induced emission, room-temperature phosphorescence, luminescent polymers, light-emitting diodes, organic semiconductors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The roles of selection and husbandry in the development of locomotory dysfunction in turkeys', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Consumers increasingly demand meat, which is both affordable and obtained from welfare friendly production systems. Currently, there is an unacceptably high level of locomotor dysfunction in growing turkeys with unprecedented levels of tibia dyschondroplasia. It has been suggested that turkey locomotor problems are a result of selection for production traits. It is also know that locomotor problems can be influenced by husbandry practices. The welfare implications of locomotor dysfunction have not been fully appraised. This project aims to address these issues and has 4 main objectives: A. To define normal gait, skeletal and related behavioural parameters in growing turkeys with unprecedented levels of tibia dyschondroplasia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterisation of south american genotypes of bean for optimal use of light under abiotic stress.' under Fifth Framework.

assistant: **Concept**

This project is to contribute to the sustainable improvement in Hazel's bean production in poor and marginal areas of South America. Genotypes able to reach optimum productivity under biotic stress will be selected. The main factor to be studied will be solar radiation. The project will be focused on the identification of genotypes with different capacities to use solar radiation in photosynthesis and in photomorphogenesis. Both, beneficial and detrimental responses to intensities and spectral ranges of radiation (including UV-B) will be studied in combination with water, temperature and nutritional stress. Cultivars will be selected and characterised from germless collections of the University of Chilean the gene bank of the International Center for Tropical Agriculture (CIAT) at Colombia. New genotypes will also be collected from areas of different latitude and altitude where there is widely differing exposure to these stress factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Building the product pipeline for commercial demonstration of Plant Molecular Factories' to be submitted under Horizon 2020.

assistant: **Abstract**

Plant Molecular Farming is the manufacture of high-value products using plant biotechnology. Pharma-Factory was conceived and designed by SMEs active in the field to produce medical, veterinary and diagnostic products. Product-driven work packages and a collective approach to public involvement and regulatory consultation will accelerate commercialisation of new bio-products, and increase the competitiveness of European bio-industry by resolving technical, social and economic bottlenecks in this field. All parts of the work programme are addressed by refining technologies using new synthetic biology tools, demonstrating manufacturing advantages for individual products, identifying a clear regulatory path for each platform technology, developing clear business cases with supporting techno-economic evaluations and life cycle analyses and improving public engagement and acceptance. Five SMEs will develop products that include arylsulfatase B (for human enzyme replacement therapy), a vaccine for infectious spleen and kidney necrosis virus in fish, two highly potent HIV neutralising antibody-based fusion proteins and plant chimaeric virus-like-particles for a diagnostic kit. In collaboration with academic partners they will advance six plant molecular farming platforms for this purpose, including whole plants, algae, hairy roots and plant cell culture, by designing and developing new tools to increase the competitiveness, utility and versatility of each platform. All companies will reach Technology Readiness Level 5 within the lifetime of the project, with two products to be commercialized. The project provides a unique opportunity to improve public involvement with plant biotechnology at a European-wide level. A work package has been dedicated to gain maximal impact by enga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DIGITAL TWINS AND ONTOLOGY FOR ROBOT ASSISTED DECOMMISSIONING OPERATIONS DORADO' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The overall aim of the DORADO project is to improve safety and efficiency in nuclear decommissioning by applying digital technologies such as Artificial Intelligence (AI) and Building Information Models (BIM) with a dedicated decommissioning ontology. In DORADO, a holistic digital platform based on a data-driven approach will be created, integrating digital tools into a coherent suite customized for decommissioning applications. Once completed, the platform can be utilized especially for in situ waste characterization, planning segregation and packing remotely, robotics and remote handling systems, sampling and clearance of surfaces and structures, cost estimation, risk identification and knowledge management, including on-site voice assistance to the fieldworkers. DORADO will focus on eight technologies that will be developed and integrated to be used with a common data server combining the data flow into a BIM model. These include, e.g., point-cloud 3D models and change detection, digital twins based ALARA dose estimation, robot mission optimization and smart voice assistant interface. After the development phase, all the results will be demonstrated with data sets collected from real nuclear facilities. An end-user group is involved throughout the project, to ensure matching a market need. Main impacts are achieved by minimizing radiation exposure and risk of occupational incidents to workers and increasing the efficiency of decommissioning planning by enabling remote operations and planning. This can result in significant cost reduction and optimized waste management strategies as well as increase the public confidence towards nuclear energy. Benchmarking digital tools with demonstrations from nuclear facilities also assists the regulators to understand the technica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Active matter information machines'.

assistant: **Objectives**

The relation between information and thermodynamics remains a fundamental thought-provoking issue since the days of Maxwell. The most effective platforms used to explore this relation are information machines: processes that convert measured information about a system to extractable work.  A crucial question that goes beyond the currently explored regime in the field is how information machines perform out of equilibrium, namely when not in equilibrium with a thermal bath. This is the general scenario of relevance to biological systems and stands at the focus of this proposal.  Our recent result, showing how temporal correlations affect the efficiency of information engines (PRL 2018), demonstrates our ability to manipulate, track, and analyze particle motion in order to address such outstanding questions experimentally. We propose to realize and study three new information engines with increasing complexity: (1) a microscopic engine that converts information to osmotic pressure, (2) a macroscopic engine that converts information to pressure, and (3) a mobile engine converting local information to directed motion. The proposed engines are unique in that they harvest work from active systems, not necessarily coupled to a heat bath, and include many particles. By measuring work and information directly, we will be able to test the validity of the generalized second law of thermodynamics and the Jarzynski fluctuation theorem in active matter systems with feedback and control loops. Providing essential, precise and detailed experimental observations in a field in which they are lacking will pave the way toward the extension of stochastic thermodynamics to active systems. Unraveling the mechanisms that govern conversion of information to useful work will benefit far-reaching
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Provision of a quality control programme for diagnostic virology'.

assistant: **Objectives**

Objectives:The objective of the CA is to establish a Pan European Quality Control programme to allow the assessment and evaluation of existing and evolving nucleic acid amplification procedures used in diagnostic virology. The purpose of the Concerted Action will be to establish a Quality Control (QC) programme for nucleic acid amplification procedures used in diagnostic virology to parallel established schemes for QC of virus serology, virus isolation, and virus antigen detection. Pan-European Quality Control programmes relating to a range of viruses of clinical importance will be sequentially introduced via the preparation and distribution of proficiency panels to evaluate test specificity and sensitivity. These will test laboratory performance, validate nucleic amplification methods, study genotype detection efficiency and via a Dual Track programme the preparation criteria of these panels will be utilised to develop certified 'standard' reagents for use as internal 'within-run' controls. During the period of the CA, six QC panels (each consisting of two panels to evaluate test specificity and sensitivity) will be prepared and distributed. Each QC programme will be linked to a workshop which will be structured to allow for the presentation of programme data, assessment of performance by individual laboratories, and information exchange concerning technical aspects of the test procedure evaluated.Keywords:Quality control, Diagnostic virology, Molecular diagnosis, PCR, Nucleic acid amplification.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Eco-innovative housing solution for efficient production of slaughterpigs with limited environmental impact.'.

assistant: **Objectives**

Pig meat is the preferred meat in Europe but its production has a dramatic environmental burden both in the local neighbour populations and in overall air pollution impact. Pig farming is at the center of clear conflict of interests, as there is a constant market drive to increase production efficiency, while society demands for an environmentally cleaner and more animal-friendly pig farming industry.  Agrifarm has developed a novel structural design for an eco-innovative barn for slaughterpigs – the Intellifarm housing solution – which makes use of its patented, prize-winning hybrid ventilation system and air cleaning technology to simultaneously reduce the need of mechanical ventilation and improve the capture of air polluting agents within the barn. The obtained results show massive energy savings compared with traditional ventilation systems, as well as a significant reduction of pollution emissions. Furthermore, it strongly contributes to an improved indoor quality, which translates into a healthier, quieter and more comfortable environment for the animals and staff inside the barn.The remaining step towards commercial exploitation of the Intellifarm is its full scale demonstration and certification. This is directly addressed in the HybridFarm project, where the most important outcome is the construction of two Intellifarms at two different end-user sites in geographical key points to enter the market. Intellifarm has the potential to decrease pig farming energy costs by 60%, while contributing to up to 50% gains in production profitability. At the same time, overall society burden of pig farming will be significantly reduced, thanks to the 71% global reduction on the emissions of ammonia and 37% reduction of odour, compared with a traditional barn. Moreover, this