RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamic Constitutional Chemistry for the Preparation of Receptors for Anions of Biological Interest' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

From chloride to DNA, over 75% of the cofactors and bio-molecules have negative charge at physiological pH. However, efficient syntheticreceptors for anionic entities in aqueous solution have attracted lesser attention than ligands for cationic or neutral species. The intrinsicphysicochemical problems of anion binding and the molecular diversity of anionic species have often hampered this research field. In this project,the identification and synthesis of new molecular receptors for anions with biological relevance is proposed. To this aim, we will use aconstitutional dynamic chemistry approach, a conceptually new methodology based on the molecular evolution idea. Thus, we will prepare adynamic library of components interconnected through exchange by chemical equilibriums. These building blocks will bear a molecular recognitionmoiety able to bind anions, and the required functional group(s) for the establishment of a covalent bond under reversible conditions. In thepresence of the target entity (an anionic template), the dynamic system will evolve to efficiently interact with the template and the best binder willbe amplified and identified. As the building blocks, we will use peptide-like molecular architectures, since they can bear different potential anionbinding functions (amide, ammonium, etc…), show large molecular and structural diversity and, in general, display good biological tolerance.Additionally, their synthetic, isolation and characterization procedures are quite straightforward. Using this rationale with anionic templates ofbiological importance, this methodology will allow us to synthesize new receptors of biologically interesting molecules with increased bindingabilities, which will be finally tested for the corresponding biological functions. Therefore,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Knowledge repository for  best agricultural practices' to be submitted under Horizon 2020.

assistant: **Abstract**

EUREKA has brought together 21 multi-actors (MA) from 16 member states and 48 supporting organizations, to co-create a stronger and reinforced EU wide agricultural knowledge base by developing an open source e-platform, called the FarmBook. This two-sided market platform, like Facebook, will address the needs and improve the connections between two distinct user groups: MA project partners and MA end users (farmers, foresters, advisors, scientists, policy makers,…). To realize this, EUREKA will first analyze the MA project knowledge supply (outputs, activities, dissemination,…) to get a comprehensive data overview and distinguish do’s and don’ts on how to co-create and transfer knowledge in these projects. From this analysis best practices and recommendations will be formulated into a MA bible for the current MA community and for EIP-AGRI (+ SWG SCAR AKIS) to improve the design of future MA projects. Participatory activities with many MA projects during EUREKA will lay the foundation to build a more engaged MA project community. All available resources that can be used to share amongst the community and to shape and promote the EUREKA outputs will also be mapped. Second, EUREKA will analyze the knowledge demand from potential end users by profiling them and determining their needs, barriers and preferences across four macro-regions in Europe and across the different agricultural sectors. Third, EUREKA will integrate the results of the analysis on the knowledge supply & demand by consulting various expert working groups to co-create a ranking of MA projects and to select the most relevant and high impact agricultural MA project knowledge for the rural and scientific community. Fourth, the FarmBook will be built to present this knowledge in an accessible, standards-based,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering rhinovirus-mediated macrophages impairment through the establishment of human induced pluripotent stem cells-derived macrophages' (MacroRhino).

assistant: **Concept**

A growing body of evidence suggest that viruses can modulate myeloid cells responses leading to long term impairment of monocytes/macrophages phenotypes. Whereas for virus directly infecting macrophages, the long-term effects on these cells function and phenotype have been extensively studied, for virus infecting other cell types, the effects on macrophages have been overlooked. Yet, recent data suggest that virus-mediated modulation of macrophages can even occurred when the virus do not replicate in these cells. Indeed, viruses have broader ways to modulate the innate immune responses than the one identified in permissive cells. Understanding the mechanisms of action employed by viruses to modulate macrophages responses could not only provide possible targets to eliminate the infection, but also offer therapeutic options to prevent/avoid virus-associated pathogenesis.Human rhinovirus (HRV) impairs macrophages’ responses upon secondary challenge with bacteria. The host laboratory identified arpin as a critical factor targeted by HRV to alter the phagocytic activity of macrophages and showed that HRV16-treated macrophages present a “paralysed” phenotype in terms of cytokine secretion. The precise mechanisms governing the reprogramming of the macrophages are however not fully elucidated. Furthermore, it is still unclear whether HRV needs to replicate within macrophages to reprogram their phenotype and functions. Therefore, my objectives are to decipher (i) if HRV can replicate in alveolar macrophages and (ii) what are the HRV-mediated mechanisms leading to impaired macrophages’ functions.Moreover, the models employed to study macrophages present advantages but do not recapitulate organ physiology, which plays a key role on the resident macrophage phenotype. Therefore, I w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Epigenetic transgenerational Effects of Parental Age on Fitness' in the context of a Seventh Framework call.

assistant: **Objectives**

Why do organisms age? This is one of the big, unsolved questions in biology, because it is unclear how a process that decreases fitness can persist evolutionarily, and why species do not evolve to live longer. Many evolutionary theories have been suggested to explain, but it is likely that multiple factors contribute to the phenomenon. One potentially very important factor has been largely ignored: transgenerational epigenetic effects of senescence. Epigenetic effects can strongly affect the predictions of evolutionary models. One such epigenetic, trans-generational factor that affects fitness is parental age. It has been known for nearly a century that a mother's age can affect her offspring's, and even her grand- offspring's fitness. However, all studies have been done in the laboratory. Therefore, it is unknown whether the effect of parental age operates in wild populations, and how it contributes to our understanding of the evolution of longevity.We propose to study the effects of parental and grand-parental age on their offspring's lifespan, reproductive success, physiology and genetics in a wild population of house sparrows. We have data available from a long-term study of sparrows in which we will examine these topics in detail. Only a closed population such as the one that we is uniquely suited for this study, as we can accurately estimate lifespan, fitness and parentage, which are all prerequisites for the longitudinal study of longevity on individual fitness. Also, we will use focused experiments with captive birds to cement our hypotheses, and individual-based simulation models to explore the implications of parental age effects on the evolution of longevity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regeneration and Optimisation of Cultural heritage in creative and Knowledge cities' to be submitted under Horizon 2020.

assistant: **Abstract**

ROCK aims to develop an innovative, collaborative and circular systemic approach for regeneration and adaptive reuse of historic city centres. Implementing a repertoire of successful heritage-led regeneration initiatives, it will test the replicability of the spatial approach and of successful models addressing the specific needs of historic city centres.ROCK will transfer the Role Models blueprint to the Replicators, adopting a cross-disciplinary mentoring process and defining common protocols and implementation guidelines. ROCK will deliver new ways to access and experience Cultural Heritage [CH] ensuring environmental sound solutions, city branding, bottom-up participation via living labs, while increasing liveability and safety in the involved areas. ICT sensors and tools will support the concrete application of the ROCK principles and the interoperable platform will enable new ways to collect and exchange data to facilitate networking and synergies. The added value is the combination of sustainable models, integrated management plans and associated funding mechanisms based on successful financial schemes and promoting the creation of industry-driven stakeholders’ ecosystems. A monitoring tool is set up from the beginning, running during two additional years after the project lifetime. Main expected impacts deal with the achievement of effective and shared policies able to: accelerate heritage led regeneration, improve accessibility and social cohesion, increase awareness and participation in local decision making process and wider civic engagement, foster businesses and new employment opportunities. Involving 10 cities, 7 Universities, 3 networks of enterprises, 2 networks of cities and several companies and development agencies, a foundation and a charity, ROCK is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Southern Ocean Silicon Cycling: combining views of the past and present using silicon isotopes' (SOSiC).

assistant: **Innovation**

The Southern Ocean (SO) is the main connection between the sunlit surface and the nutrient- and carbon-rich deep ocean. Deep waters are brought to the surface here, resulting in outgassing of carbon dioxide (CO2) and providing nutrients to the global surface ocean. The SO thus has great importance for the carbon cycle and marine cycles of nutrients, most markedly that of silicon (Si). Si is vitally required by diatoms, siliceous phytoplankton that are important in exporting carbon from the surface ocean and maintaining the ocean’s biological pump, linking the Si and carbon cycles.The SO is the main window via which the ocean exchanges carbon with the atmosphere, and has been implicated in altering atmospheric pCO2 over glacial/interglacial (G/IG) cycles. SO Si cycling has also varied over G/IG timescales, reflected by changes in the accumulation rate and silicon stable isotope composition (d30Si) of diatom opal recovered from sediment cores. These proxies suggest that changes to SO nutrient dynamics allowed it to export Si to the upper ocean in glacial times, with widespread consequences for plankton biogeography, carbon cycling and climate. The d30Si proxy is a vital constraint in these reconstructions, but while extant records demonstrate its potential, they are too sparse and poorly-resolved to allow robust conclusions.Our goal is a step change in our understanding of SO cycling of Si and its isotopes, both in the present and over G/IG cycles. We aim to:- Study the seawater d30Si distribution across the fronts of the SO, in order to better understand modern Si transport between the regions of upwelling (Antarctic zone) and thermocline supply (Subantarctic zone);- Produce high-resolution diatom opal d30Si records from sediment cores in the Antarctic and Subantarctic z
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Topological Quantum Devices' (QTOPDEV).

assistant: **Innovation**

Topological behavior has emerged as a new paradigm in contemporary condensed matter physics. To date, only a relatively small subset of the myriad of possible topological phenomena has been accessed experimentally or utilized for technological applications. In this research program, we will consider devices synthesized of several accessible components, which can potentially allow access to new topological phases, as well as promote several important technological applications. The program consists of three main research directions. The first will focus on defects in topological phases as platforms for performing topological quantum computation. We will study the general mathematical theory describing the defects, as well as a more microscopic analysis of zero modes bound to defects.  We will study the quantum information processing capabilities that can be achieved by controlling the coupling between the defects, as well as by coupling defects to external systems.  We will also construct lattice models of interacting defects, and study the possible quantum phases of matter which they give rise to.  A second research direction will deal with the photo-current response of hetero-structures containing topological insulators. We will study the possibility of inducing magnetic or electrostatic superlattices on topological insulator surfaces in order to enhance their photo-current harvesting capabilities. These structures may serve as a route for constructing new photo-voltaic devices. A third direction will deal with systems in which the topological phenomenon is induced dynamically by an external periodic drive. We will study theoretically the feasibility of realizing and detecting topological phenomena in a non-equilibrium setting. Such a setting will require us to conside
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DAL: Defying Amdahl's Law', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Multicore processors have now become mainstream for both general-purpose and embedded computing. Instead of working on improving  the architecture of the  next generation multicore, with the DAL project, we deliberately anticipate the  next few generations of  multicores.While multicores featuring 1000's of cores might become  feasible around 2020, there are strong indications that sequential programming style will continue to be dominant. Even future mainstream parallel applications will exhibit large sequential sections.  Amdahl's law  indicates that high performance on these sequential sections is needed to enable overall high performance on the whole application. On many (most) applications, the effective performance of future computer systems using a  1000-core processor chip  will significantly depend on their performance on both sequential code sections and single thread.We envision that,  around 2020, the processor chips will feature a few complex cores  and many (may be 1000's) simpler, more silicon and power effective cores.In the DAL  research project, we will explore the microarchitecture techniques that will be needed to enable high performance on such heterogeneous processor chips. Very high performance will be required on both sequential sections -legacy sequential codes, sequential sections of parallel applications- and critical threads on parallel applications -e.g. the main thread controlling the application.  Our research will  focus on enhancing single process performance. On the microarchitecture side, we will explore both a radically  new approach, the sequential accelerator,  and more conventional processor architectures. We will also study how to exploit heterogeneous multicore architectures to enhance  sequential thread performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stimulating Policy Debate on Women and Science Issues in Central Europe' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Major overall objective of the WS DEBATE project is the stimulation of policy and public debate on the situation and perspectives of women in science, in order to bridge the gap between policy developments and public understanding of the related issues, and to raise gender awareness among policy makers, scientists, as well as among the lay public interested in scientific developments.This objective will be realized by encouraging a broad public debate based on the dissemination of the knowledge gathered by the Enwise report (Waste of talents: turning private struggles into a public issue - Women and Science in the Enwise countries; European Commission, EUR 20955 EN) in the countries of Central Europe (Czech Republic, Hungary, Poland, Slovakia, Slovenia).The distribution, dissemination and media presentation of the Enwise report (in the local languages) is the logical first step after the delivery of the report and its valorisation conference in Tallinn (Enlarging Europe with/for Women Scientists?, September 10-11, 2004). As the Enwise report itself is reflecting continuity of a number of efforts already made in the same direction by the European Commission, this project is aiming to make the continuity visible for the respective audiences of policy makers and scientists, as well as of target groups still unaware of the issue in Central Europe by involving also mass media.The project will also support the process of implementation of Enwise recommendations, which should enable long run sustainability of those efforts in the CE countries, as well as contribute to the promotion of a dialogue on best gender equality practice. The partners in the project are the Enwise experts or closely related organisations of the respective countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evolution of Highly Ionized Gas Over Cosmic Time' (EHIG) targeting Sixth Framework.

assistant: **Abstract**

I propose to study the properties of the highly ionized gas in the intergalactic medium using ground-based spectroscopy of high-redshift quasars. Observations of absorption lines of the highly ionized species O VI, N V, and C IV provide a way to measure th e properties of this highly ionized gas, which is thought to harbour a significant fraction of all baryons. Using data from the UVES spectrograph on the Very Large Telescope Chile (a European facility), I aim to look for evolution in the properties of O VI absorption systems with redshift. Specifically, I will: (a) determine whether highly ionized intergalactic absorbers contain multiple gaseous phases; (b) seek an understanding of the differences between highly ionized gas at low redshift and high redshift ; c) test the predictions of cosmological simulations; and (d) investigate the origin of hot gas in Damped Lyman alpha systems (DLAs), that may represent the high-redshift precursors of galaxies like the Milky Way. This project will make use of new spectr al analysis techniques pioneered at the Institut d'Astrophysique de Paris (the host institution), which correlate the absorption in spectra separated by small angular scales on the sky. This technique will enable the spatial distribution of highly ionized gas in the high-redshift Universe to be studied for the first time.