RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative biodiagnosis meets chemical structure elucidation – Novel tools in effect directed analysis to support the identification and monitoring of emerging toxicants on a European scale' under Seventh Framework.

assistant: **Concept**

EDA-EMERGE aims to train a new generation of young scientists in the interdisciplinary techniques required to meet the major challenges in the monitoring, assessment and management of toxic pollution in European river basins considering the enormous complexity of contamination, effects and cause-effect relationships. By integrating innovative mode-of-action based biodiagnostic tools including in vitro tests, transgenic organisms and “omics” techniques with powerful fractionation and cutting edge analytical and computational structure elucidation tools, a new generation of effect directed analysis (EDA) approaches will be developed for the identification of toxicants in European surface and drinking waters. Innovative method development by young researchers at major universities, research centres and private companies will be closely interlinked with a joint European demonstration program and higher tier EDA and extensive training courses. EDA-EMERGE ESRs will learn to organise and run international and interdisciplinary sampling and monitoring campaigns and benefit from the expertise of one of the most experienced private companies in this field. Strong networking between academia, the private sector and leading regulators in the field of river basin management and pollution management ensures the relevance of the research for practice and excellent employment opportunities for EDA-EMERGE ESRs. The combination of cutting edge science with training in multiple complementary (soft) skills offered with a strong emphasis on commercial exploitation and media competence will further enhance employability of well-trained ESRs not only in research and academia but far beyond. An internationally composed advisory board will introduce new perspectives of monitoring, assessment an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The proteins of sorghum and millets: enhancing nutritional and functional properties for africa' (AFRIPRO) targeting Fifth Framework.

assistant: **Abstract**

1. To hold a workshop with participants of EC-funded research projects on sorghum and millets and scientists and technologists from eastern, central and southern Africa.2. To use the workshop to share information, results and ideas.3. To identify gaps in knowledge and needs and opportunities for new research.4. To develop proposals for the formation of networks and cooperative research programmes between and within scientists in Europe and Africa.5. To produce an edited proceedings of the workshop, which will document the presentations, discussions, identification of gaps in knowledge and recommendations for new research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transformative Pediatric Brain Cancer Imaging using Integrated Biophysics-AI Molecular MRI' to be submitted under Horizon Europe.

assistant: **Abstract**

Despite vast drug development efforts, brain tumors remain the leading cause of pediatric cancer deaths. Noninvasive monitoring of treatment response is crucial to reveal the mechanisms behind tumor-drug interactions and optimize patient care. However, standard magnetic resonance imaging (MRI) methods involve injecting metals, have severe difficulties in differentiating treatment response from tumor progression, are qualitative, and mandate prolonged anesthesia due to the lengthy acquisition. I propose to develop a transformative molecular MRI technology, based on the chemical exchange saturation transfer (CEST) contrast mechanism that will enable specific, quantitative, rapid, contrast-material free, treatment monitoring of pediatric brain cancer. Recently I revealed that a combination of mathematical CEST models and AI can generate quantitative biomarker maps of pH and protein concentration changes across the brain, two known hallmarks of cancer. Inspired by these results, I now propose to adopt a previously unconsidered perspective and to represent the underlying physics of CEST MRI as a computational graph, enabling an automatic AI-based optimization of molecular imaging. I hypothesize that the combination of biophysical models with a new AI framework, and their synergetic integration throughout the entire imaging pipeline will provide accurate noninvasive treatment monitoring. First, I will establish a method for automated optimization of MRI protocols for early determination of the tumor response to mainstream chemotherapy. Next, I will shorten the 3D scan time by an order of magnitude and quantify the response to next generation immunotherapy. Third, I will translate the method to clinical scanners and validate it in a human pediatric pilot study. This research w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Understanding the dynamics of the immune system to cure graft-versus-host disease (GvHD).' (GvHD) targeting Horizon 2020.

assistant: **Abstract**

Acute graft-versus-host disease (GvHD) is the leading cause of the high mortality of patients having undergone allogeneic hematopoietic cell transplantation. A key event in the pathogenesis of GvHD is the injury and loss of epithelial cells in the intestinal tract. The overall goal of GvHDCure is to identify the pathophysiological mechanisms that initiate (1), propagate (2) and maintain (3) GvHD. (1) We found that one of the earliest events during GvHD initiation is infiltration of the intestines by neutrophils. By using transgenic neutrophil cell lines carrying selective gene defects, we will systematically evaluate molecules in neutrophils that are critical for their sensing and effector function during GvHD in combination with novel imaging methods to track bacterial translocation. (2) The molecular programs propagating inflammation-induced epithelial apoptosis, endoplasmic reticulum stress and the sensing of DAMPs in GvHD are not understood. We will isolate enterocytes from GvHD mice to develop a precise quantitative genomic and micro RNA (miR) fingerprint of their death. The connection between ER stress and enterocyte death will be validated in intestinal organoid culture systems and in vivo in an XBP-1 mRNA splicing reporter mouse. In addition, we will make use of our human tissue bank, allowing the efficient genetic screening and verification of regulatory molecular networks in the cells from GvHD patients. (3) Maintenance of GvHD relies on continuous immune cell activation. Based on our miR array and phospho-proteomics data set, we will selectively analyze the role of several miRs and kinases in neutrophils, dendritic cells, T cells and enterocytes for GvHD maintenance by using multiple Cre-lox mice and kinase inhibitors to manipulate GvHD. Via a combination of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'THE UNCHARTED BRAIN TERRITORY - The (pre)Supplementary Motor Area and its role in language cognitive control in health and neurodegeneration' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The function of white matter networks of the human brain is a key inquiry of contemporary neuroscience. Initial observations suggest that damage to the white matter system connecting the pre-supplementary and supplementary motor areas ((pre)SMA) with frontal cortices and caudate nuclei may impair both language and cognition. However, it is unclear which exact cognitive mechanisms are compromised and if specific projections of this network obey to a division of labor. Providing this knowledge is of the utmost importance for a variety of neurological populations, but especially for Huntington´s Disease (HD) - a rare genetic disease that represents a neurodegeneration model, with alterations in both (pre)SMA system and language/cognitive difficulties. PreSMAcog proposes a multidisciplinary, precise description of the (pre)SMA system. To achieve this, I will (1) provide a neuroanatomical characterization of the system using structural neuroimaging techniques (diffusion tensor imaging) and laboratory dissections in both HD and healthy individuals, (2) explore the links between structural properties of the (pre)SMA system and cognition and (3) design a sensitive tele-assessment of language and cognition in HD. I will conduct this research in Barcelona joining a team of ultimate experts in neuroimaging and language/cognitive neuroscience with long-standing experience in HD research. Furthermore, I will implement, for the first time in HD, an innovative brain connectivity mapping technique supervised by its pioneer (secondment in Oxford). PreSMAcog will enhance my current expertise leading me towards independence in multidisciplinary neuroscience research and academic leadership. The synergy between four major disciplines of neuroscience (neuroanatomy, language/cognitive neuros
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'CHARACTERIZATION, COMPATIBILIZATION, PROCESSING AND PROPERTIES OF RECYCLED POLYOLEFINS'.

assistant: **Objectives**

CHARACTERIZATION, COMPATIBILIZATION, PROCESSING AND PROPERTIES OF RECYCLED POLYOLEFINS (REPOL) is a European Industrial Doctorate established by a consortium of leading European scientists in the academic and private industrial sector of polymer science and engineering. The University of the Basque Country (SP) and the University of Genova (IT) are the academic beneficiaries while Borealis is the industrial beneficiary (AT). They will collaborate in research-related and transferable training activities, through the execution of individual projects of three early stage researchers (ESRs) with a highly synergic, intersectoral and multidisciplinary approach in the field of polyolefins recycling. Currently, effective and innovative upgrade polyolefins recycling technologies are urgently needed to address global environmental concerns. European industries require skilled researchers to exploit academic knowledge on polymer chemistry, physics, and engineering, and switch innovation and investment from an economic system to an ecological one, driven by circular economy. In this sense, the REPOL project will address these challenges through a combination of fundamental and applied research training programme to enhance the scientific excellence and competitiveness of polymer recycling in Europe. The project aims to develop characterization tools for recycled polyolefins, find novel compatibilization routes, design upgraded recycled postconsumer based blends and nanocomposite blends, and study the scalability of the developed recycled materials. REPOL will become a reference at the International Level, improve R&D capacity between participating organisations and boost synergies and better knowledge transfer between sectors in the area of polymer recycling, by promoting the mobil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Lobbying (A)symmetry: The Dynamics Behind Informed Policy' (LOBBYMETRY) under Horizon Europe.

assistant: **Objectives**

The LOBBYMETRY project addresses two types of imbalances in lobbying: 1) mobilisation asymmetries, which exclude some actors from the policy debate, and 2) information asymmetries, which empower specific groups in their exchanges with policymakers. The LOBBYMETRY project analyses these asymmetries and their relationship to each other, as well as their effects on the ways in which sectional and public interests feed into policymaking.The project studies these asymmetries across populations of interest organisations in twelve European countries and at European Union level, as well as within the climate and digital policy fields, that vary strongly in mobilisation asymmetries and constitute areas where well- or ill-informed policies have vast consequences for humanity at large. LOBBYMETRY strives to open the black-box of policymaker-lobbyist information exchange within these areas, develop measures of informational quality and accuracy in lobbying, and evaluate how and when lobbying pulls outcomes away from the public interest.Methodologically, the project combines cross-country surveys including an AI-aided survey experiment, cross-venue data on 100 issues in climate and digital policy, and different forms of participant observation of the information exchanges between policymakers and interest organisations in i) natural and ii) researcher-controlled settings. This innovative combination of methods will generate unprecedented quantitative and qualitative evidence on lobbyist-policymaker information exchange in varying contexts.If successful, the project will shed light on a serious blind spot in the state-of-the-art literature: the mechanisms through which lobbying actually informs policies. Its findings will speak to pressing democratic challenges, such as the underrepr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'advanced Audience measurement Research Extended to New convergent media Applications and services' (ARENA), addressing dissemination and exploitation.

assistant: **Impact**

Audience research is a vital part of TV and radio broadcasting, and of the more recent forms of media content delivery, such as the Internet, mobile phones, PVRs and portable media viewers. These newer devices are examples of the convergence of broadcasting, IT and telecoms, and are at the centre of the information-led economy the EC is promoting. The uses for audience research range from self-promotion to refining service offerings and negotiating advertising rates. Without reliable audience data, many businesses will be reluctant to participate in the new platforms.<br/><br/>This rapid proliferation of platforms and service has brought new challenges for audience research. When there was only analogue TV, there were very few channels to choose from, and each channel had its own frequency detectable from the TV set. Technically it is no longer that simple, and there are no commonly accepted metrics for new media audiences", if that is still the right word. The technologies and the form of the results diverge as they follow the properties of individual platforms. When the same content is available from different sources, it becomes difficult to aggregate and compare audience figures.<br/><br/>ARENA intends to devise a basic methodology and an application of open standards that can be applied across platforms and services, and to demonstrate implementations derived from this common base for specific instances. <br/><br/>It will do this by analysing requirements, and creating a reference model that it will simulate on general-purpose hardware before moving to specific implementations. Existing open standards will be used for modelling, implementations, and for representing media content and audience classification. The work will be publicised, and contributions made back
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integration of traffic control with other measures' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

1- Develop and integrate strategies for optimization of Urban Traffic Control (UTC), Driver Information Systems (DIS) and Public Transport Systems (PTS) within Urban Traffic Management Systems (UTMS). %2- Establish EU, national and local policies/user requirements for integrated Urban Traffic Management Systems (UTMS) and strategies 3- Review integrated UTMS in EU and strategies/softwares for their optimization 4- Evaluate integrated strategies though field trials supported by simulation in London, Turin, Gthenburg and Piraeus. 5- Produce guidelines on effectiveness of different integrated strategiesLondon (UK), Torino (IT), Gothenburg (SE), Piraeus (GR) %Transport RTD programme : projects MUSIC, CAPTURE, OPIUM and SESAME Telematics programme : project COSMO"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fashioning Heads: Valorising Novelty in Eighteenth-Century France' (AXIONOVI), addressing dissemination and exploitation.

assistant: **Impact**

This research investigates innovatory practices and the importance of novelty in eighteenth-century France by considering the specific case of fashion in women’s coiffures. At the crossroads of cultural and material history, it will examine how the search for novelty governed the coiffures trade and how these practices contributed to shape the concept of novelty, at a crucial moment when it became a core attribute of modernity. By focussing on the innovatory strategies of the different actors involved in the creation and the commercialisation of fashionable coiffures, the research will attempt for the first time to map a field, which is still uncharted despite its importance during the Ancien Régime. Drawing on a wide range of primary sources, from merchants’ account books to fashion plates and advertisements, and combining different historiographical approaches, this project will shed light on the relations between merchants in different trades, fashion journal editors, customers and government agencies. The investigation will also address the importance of novelty in global trade and foreign imaginaries, by analysing the relationship between economic and symbolic conceptions of value. This undertaking will reassess the role of fashion in the culture and economy of eighteenth-century France: through new archival research it aims to re-connect fashion with the wider philosophical and economic reflexion on the notion of novelty in the Ancien Régime The project also includes a practical component through the recreation of historical coiffures in a fashion museum. This hands-on research methodology, documented in a blog, will not only offer a better understanding of how these hairstyles were made, but it will also reflect on the utility of re-creation both in historical re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploiting genome replication to design improved plant growth strategies' under Horizon 2020.

assistant: **Concept**

This project will identify the principles governing genome replication in relation to the chromatin landscape and how they impact on plant organ growth. The results will provide the basis to design novel strategies to improve plant growth performance. The large plant genomes, as in all eukaryotes, must be faithfully duplicated every cell cycle, a process regulated at the level of DNA replication origins (ORIs). Our understanding of how ORIs are determined is still very limited. Most of our knowledge comes from cultured cells, precluding the identification of regulatory layers operating at the organism level. Importantly, genome replication can offer unexplored possibilities to modulate plant architecture and growth and, consequently, plant performance.Results generated so far unable us to address a fundamental question: what are the regulatory mechanisms of DNA and genome replication and how they can be exploited to design improved plant growth strategies. This innovative perspective will reveal how genome replication is regulated by DNA sequence context, replication factors and chromatin landscape.  Integration of molecular, cellular, genomic and genetic approaches in a whole organism will serve to evaluate the phenotypic effects of modulating genome replication on organ growth. We will also learn how DNA replication control is exerted during endoreplication and in coordination with transcriptional programs, both crucial for plant organogenesis, growth and response to environmental stresses.This program goes beyond incremental research, is timely, innovative, ambitious but realistic, and high risk/high gain, combining different approaches to address a fundamental process. Given the conservation of proteins and pathways, and the availability of well-annotated genomic in