RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cell-Cell fusion in fertilization and developmental biology: a structural biology approach' in the context of a Seventh Framework call.

assistant: **Objectives**

My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a cell. This aim of this ERC grant proposal is to achieve similar breakthroughs in understanding fusion between cells, both during fertilization and organogenesis. This proposal is based in recent important results not yet published.We have determined the crystal structure of the C. elegans protein EFF-1, a member of the “fusion family” (FF). EFF-1 is responsible for a cell-cell fusion event during skin formation in the nematode. Strikingly, the crystal structure shows that EFF-1 is homologous to the “Class II” viral protein fusogens, thus indicating that they have diverged from a common ancestor. The observed homology could not be identified by other means because the proteins have diverged to the point where no remnants of sequence similarity are left, yet the tertiary and quaternary organization is the same. However, the homotypic fusion mechanism of EFF-1 is clearly different to that of viral fusion proteins.This proposal intends to build on the momentum generated by this exciting discovery, in an attempt to cast light into the fusion mechanism of FF proteins. We will reconstitute them in artificial liposomes and will also follow them within cells with the use of light microscopy. We will also focus in determining the crystal structure of the monomeric pre-fusion form of EFF-1,and of the intact trans-membrane post fusion trimer. In parallel, we want to make use the experience accumulated over the years in crystallizing viral glycoproteins, to apply it to the conserved family of HAP2/GSC1 proteins involved in fusion of gametes during fertilization. These proteins exhibit a similar pattern of secondary structure elements in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gaseous detectors for neutrino physics at the European Spallation Source' under Horizon Europe.

assistant: **Concept**

The recent detection of the coherent elastic neutrino-nucleus scattering (CEnNS) opens the possi- bility of using neutrinos to explore physics beyond the Standard Model deploying small detectors. However, the CEnNS process generates signals at the few keV level, requiring very sensitive detection technologies. The European Spallation Source (ESS) has been identified as an optimal source of low energy neutrinos offering an opportunity to explore at depth the physics of CEnNS, with large discovery potential. In this project, I propose to apply the high-pressure noble gas TPC technology to the detection of the CEnNS process at the ESS. This will require the detection techniques sensitive to very low-energy depositions as well as improving the current knowledge of the quenching factor for nuclear recoils in xenon, argon and neon gas at keV energies. This project proposes the development of a novel detector able to hold 20 kg of xenon gas at high pressure. The device will operate at the ESS, providing more than 7,000 CEnNS events per year, potentially overtaking the sensitivities of much larger detectors in current spallation sources. Operation with xenon will explore most of the possible new physics associated with the CEnNS process. Furthermore, the high pressure technology offers the possibility to operate the same detector with different gases at minimal extra costs, thus providing a unique tool to further explore any signatures of new physics at the ESS.


**Keywords:** neutrino, gas-detectors, coherent-scattering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tobacco cessation within TB programmes: A ‘real world’ solution for countries with dual burden of disease', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

We aim to reduce the burden of tobacco-related lung diseases. Our approach is to integrate inexpensive tobacco cessation strategies of proven efficacy into TB control programmes. This has three advantages: a) Preventing non-communicable diseases as well as reducing TB-related deaths; b) TB patients are more likely to quit tobacco than healthy smokers – ‘teachable moments’; and c) in the absence of specialist infrastructure, an approach to ‘piggyback’ cessation on existing programmes is a desirable policy imperative. We will first assess the effectiveness and cost-effectiveness of tobacco cessation strategies in helping TB patients to quit and improving their TB outcomes - the effectiveness goal; and then explore how best these strategies can be delivered, sustained and scaled-up – the implementation goal. We propose six work packages for Bangladesh, Nepal and Pakistan - high TB and tobacco burden countries.WP1 Development & Feasibility: To optimise the delivery of tobacco cessation strategies within TB programmes (focus group discussions [FGD], interviews, surveys, expert panel workshops)WP2 & 3 Effect and economic evaluation: To assess the effectiveness and cost effectiveness of cytisine with behavioural support vs. behavioural support alone on tobacco cessation and TB outcomes (randomised controlled trial [RCT])WP4 Process evaluation: To study the design and delivery of the tobacco cessation strategies (FGD, observations, exit interviews)WP5 Context evaluation:  To study the influence of contextual factors on the RCT outcomes (lit. review, interviews, surveys, analysis)WP6 Scale up & Sustainability: To assess sustainability of the cessation strategies and identify the likely costs, obstacles and opportunities for scaling these up (FGD, interviews, cost and outcomes an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'BUILDING UP MODERN BIOTECHNOLOGIES FOR AGRICULTURE' (MOBITAG).

assistant: **Innovation**

The Region of South Bohemia, which occupies Eastern half of the convergence region CZ-NUTS 2 Southwest, lacks large industries and relies to great extent on the country-side. The Biology Centre of the Academy of Sciences (BCAS) located in the District plays important role in assessing environmental impact of various activities but contributes little to the implementation of novel technologies that would enhance and diversify productivity. MOBITAG project is the first and crucial step to rectifying the situation through the development of modern research capacities with the aid of colleagues from advanced parts of EU. This goal is directly related to the intended construction of the Biotechnological Institute of Applied Ecology. The project aims at enhancing BCAS research potential to a level allowing development and deployment of novel biotechnologies for a highly productive, environment-friendly, and sustainable agriculture. Research enhancement will target areas: (1) Genome analysis; (2) Exploitation of natural compounds; (3) Transgenosis; (4) Safety aspects of GMO. Another goal of MOBITAG is the support of managerial skills, especially in respect to FP7. Dissemination activities will be focused on the education of farmers as well as general public about contemporary agrobiotechnologies. Project results will be provided to regional authorities and higher level politicians to be used in the preparation of R&D&I plans and agricultural policy.      Project goals will be achieved through (1) Recruitment of experts who are working in BCAS on temporary basis, (2) Return of experienced researchers working in USA), (3) Training of BCAS staff in EU laboratories, (4) Participation of EU scientists in BCAS research, (5) Mobility of researchers, (6) Training of research managers,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Excelling LABUST in marine robotics' under Horizon 2020.

assistant: **Concept**

Laboratory for Underwater Systems and Technologies (LABUST) at the University of Zagreb Faculty of Electrical and Engineering (UNIZG-FER) in Croatia positioned itself in the last years as the regional leader in marine robotics: LABUST has the required technologies, people, infrastructure, and experience in field experiments. What LABUST is missing is research excellence that will allow it to fully exploit and bring available resources to a level compatible with internationally leading institutions in the area of marine robotics.  The main goal of EXCELLABUST project is to address networking gaps and deficiencies between UNIZG-FER and internationally leading counterparts at EU level, by significantly strengthening marine robotics research within LABUST through twinning with expert partners. The first objective is to increase UNIZG-FER marine robotics scientific excellence and innovation capacity, and raise staff's research profile within three strategic research domains (SRDs) that are aligned with the Strategic Research Agenda for Robotics in Europe 2014 - 2020: 1) mapping and perception, 2) advanced navigation, guidance, and control, and 3) autonomy and cognition. The second objective is to increase UNIZG-FER scientific involvement and visibility.These objectives will be reached through a set of strategic measures: staff exchanges and expert visits for providing S&T knowledge transfer; on-site trainings for providing hands-on S&T experience; innovation management trainings; organization of research-industry workshops for strengthening links to marine robotics industry; and joint organization of summer schools with strong emphasis on application of marine robotics for strengthening links to marine robotics end-users from marine biology, marine archaeology, oceanography,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advancing sustainable AGRIculture through off-grid energy and COOLing solutions in Africa' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Large parts of sub-Saharan Africa have no or only limited access to the electricity grid. Therefore, many farmers cannot adequately cool their product. This results in an enormous loss and waste of food, which is responsible for more than 10% of total anthropogenic greenhouse gas emissions worldwide. Cooling the food by inefficiently using generators on fossil fuels  the most common alternative  is not climate friendly either.AGRI-COOL will address both problems with a containerized solution in which food can be stored and cooled. It combines the use of photovoltaic technology, thermal energy storage by phase change materials, chillers, and smart control strategies to offer an affordable, scalable and  climate friendly solution.The AGRI-COOL system will be demonstrated in rural communities in South Africa, Cape Verde, Somalia, and Zimbabwe to showcase its adaptability to different climatic conditions. A life cycle assessment following the cradle-to-grave approach will be conducted to show the systems impact on environment and Paris targets compared with competing approaches. A comprehensive market and business strategy will be developed for adoption of the system after the project. Training programs for farmers, technicians, and engineers that are tailored to local conditions will ensure that the system can be installed, operated, and maintained locally. Lastly, an advanced course for third party engineers from various African countries will be organized on the design, customization, and broader economic and social aspects of the system.AGRI-COOL is going to empower rural African communities and industries by enhancing food security, reducing waste and fostering economic growth while contributing to achieve the African countries targets of the Paris Agreement. A balance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dynamically Reconfigurable Optical-Wireless Backhaul/Fronthaul with Cognitive Control Plane for Small Cells and Cloud-RANs' under Horizon 2020.

assistant: **Concept**

Small Cells, Cloud-Radio Access Networks (C-RAN), Software Defined Networks (SDN) and Network Function Virtualization (NVF) are key enablers to address the demand for broadband connectivity with low cost and flexible implementations. Small Cells, in conjunction with C-RAN, SDN, NVF pose very stringent requirements on the transport network. Here flexible wireless solutions are required for dynamic backhaul and fronthaul architectures alongside very high capacity optical interconnects. However, there is no consensus on how both technologies can be most efficiently combined.5G-XHaul proposes a converged optical and wireless network solution able to flexibly connect Small Cells to the core network. Exploiting user mobility, our solution allows the dynamic allocation of network resources to predicted and actual hotspots. To support these novel concepts, we will develop:1) Dynamically programmable, high capacity, low latency, point-to-multipoint mm-Wave transceivers, cooperating with sub-6-GHz systems;2) A Time Shared Optical Network offering elastic and fine granular bandwidth allocation, cooperating with advanced passive optical networks;3) A software-defined cognitive control plane, able to forecast traffic demand in time and space, and the ability to reconfigure network components.The well balanced 5G-XHaul consortium of industrial and research partners with unique expertise and skills across the constituent domains of communication systems and networks will create impact through:a) Developing novel converged optical/wireless architectures and network management algorithms for mobile scenarios;b) Introduce advanced mm-Wave and optical transceivers and control functions;c) Support the development of international standards through technical and techno-economic contribution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '5G-enabled Growth in Vertical Industries' under Horizon 2020.

assistant: **Concept**

The vision of the 5Growth project is to empower verticals industries such as Industry 4.0, Transportation, and Energy with an AI-driven Automated and Sharable 5G End-to-End Solution that will allow these industries to achieve simultaneously their respective key performance targets. Towards this vision, 5Growth will automate the process for supporting diverse industry verticals through (i) a vertical portal in charge of interfacing verticals with the 5G End-to-End platforms, receiving their service requests and building the respective network slices on top, (ii) closed-loop automation and SLA control for vertical services lifecycle management and (iii) AI-driven end-to-end network solutions to jointly optimize Access, Transport, Core and Cloud, Edge and Fog resources, across multiple technologies and domains. The main objective of 5Growth is the technical and business validation of 5G technologies from the verticals’ points of view, following a field-trial-based approach on vertical sites (TRL 6-7). Multiple use cases of vertical industries (Comau, Efacec_S, Efacec_E, Innovalia) will be field-trialed on four vertical-owned sites in close collaboration with the vendors (Ericsson, Interdigital, NEC, Nokia) and the operators (Altice, Telecom Italia, Telefonica) in the project. 5Growth will leverage on the results of 5G-PPP Phase 2 projects where slicing, virtualization and multi-domain solutions for the creation and provisioning of vertical services are being developed and validated, e.g. 5G-TRANSFORMER and 5G-MONARCH. Two ICT-17-2018 5G End-to-End platforms, 5G EVE and 5G-VINNI, have been selected for the Trials to demonstrate the 5Growth specific vertical use cases. In addition to the impact on vertical-oriented standards (e.g., EN50126 (IEC62278) for railway signaling),
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular Visualization of High Performance Computing Simulations with VTX' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Molecular Dynamics Simulations (MD) are widely used in molecular and structural biology and drug discovery to study the structure, properties and dynamics of small and macromolecules. The size of the simulated systems (up to a billion atoms) and the length of the simulations (from microseconds in 2010 to milliseconds in 2021 in million atom scenes) have dramatically increased following the recent advances in computing hardware (GPU clusters) and storage. Additionally, with the recent advances in Cryo Electron Microscopy and the arising of AlphaFold many new models of macromolecular structures and complexes are now available for molecular simulation. Due to their more and more extreme size, the storage, analysis and visualization of the resulting data is becoming problematic: 1. Technically for a usable and efficient processing of the data and 2. Environmentally in terms of storage, bandwith and power comsumption.  Within the ERC ViDOCK project, we created a highly usable, free and open-source high-performance molecular visualization software called VTX. VTX is optimized to handle the biggest molecular structures and trajectories notably by including cutting-edge molecular graphics with a high performance graphics engine coupled with a video game based minimalistic task-oriented GUI to maximize its usability.The goal of the VTX-HPC project is to improve the performance, usability and sustainability of VTX for the visualization of the High Performance Computing Molecular Dynamics Simulations big data by developing and implementing 1. a highly compact molecular structure and trajectories file format optimized for streaming for increased performances and reduced environmental load. 2. a meshless version of the widely used Solvent Excluded Surface representation for scalabil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'STRENGTHENING COOPERATION IN MOLECULAR BIOMEDICINE BETWEEN EU AND UKRAINE' (COMBIOM) under Seventh Framework.

assistant: **Objectives**

True European leadership at the emerging frontiers of biomedical sciences could be achieved more effectively with participation of the most prominent scientists from the ENP countries. Ukraine is a country of high potential for scientific and technological development. Institute of Molecular Biology and Genetics is one of the leading scientific centres in molecular biomedicine area in Ukraine, which has rather good results in the fundamental research and development of effective diagnostics and therapy of oncological and neurodegenerative diseases. Widening and deepening  the existing bilateral collaboration with two EU partners: Gustave Roussy Institute of Oncology, France, and International Institute of Molecular and Cell Biology, Poland, will provide creation of a new research consortium for enhanced involvement of the Ukrainian research center into the ERA (first objective). Supported by the EU partners the building of international cooperation capacities of the Institute for its successful participation in European collaborative research will elucidate its potential for European community and will result in widening the ERA and engagement of new participants in increased number of successful projects (second objective). Development of the Institute’s Research Strategy as a result of SWOT analysis of its research possibilities in molecular biomedicine under supervision of international Advisory Board with participation of the EU partners  is our third objective. Having improved opportunities, the Institute will provide broader activities on popularization of science and raising social awareness of the modern biotechnology and biomedicine benefits (fourth objective). We will leverage the activities of the existing informational unit and use the available electronic m