RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EUROPEAN DEVELOPMENT OF A FIRST COMMERCIAL BIONIC VESTIBULAR IMPLANT FOR VESTIBULAR DYSFUNCTION - 2' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In this project we present a solution to restore balance and prevent falls through vestibular implantation and electrical stimulation of the otolith organ. Worldwide, about 684.000 individuals die from falls each year and 37.3 million falls require medical attention.  The medical cost for treating falls in the EU is approximately 25 billion euros each year.  This number can be expected to go up since the elderly population is growing. One of the most important causes of falling is vestibular dysfunction. Therefore, restoration of the vestibular function may revolutionize this field because it offers a whole new treatment paradigm. The foundation of vestibular dysfunction treatment was laid during the Bionic\VEST H2020 FET-OPEN project funded by the EU. This FET-OPEN project obtained spectacular results and showed that the successful restoration of vestibular function through electrical stimulation of the otolith organ is possible. Where there was no suitable treatment before, balance improvement and even restoration is feasible. The result of this first Bionic\VEST FET-OPEN project was a proof-of-principle on humans with a prototype otolith vestibular implant. To unlock the full commercial potential of this vestibular restorative therapy, the new Bionic\VEST-2 project will focus on the path to commercialization of the Bionic\VEST implant. This requires improvements in the implant technology to achieve its full potential on the market. A pivotal clinical trial will have to be run with the new device to provide evidence for the safety and efficacy of the final implant, as well as gather data for health economics. Further, novel diagnostic clinical tools will be developed to identify the patients that can benefit from this technology promptly. In-depth market research and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Twice as Hard, Half as Good? Women Candidates’ Experience of Sexism on the Campaign Trail' under Horizon 2020.

assistant: **Concept**

How does sexism affect women’s pathway to political office? Scholars have claimed that voter sexism is over because women candidates win elections at the same rate as men. However, the emergence of a gender equality backlash, misogynistic social media campaigns and the continued under-representation of women in political office globally, indicate a need to re-examine whether sexism acts as a barrier to women’s representation. To better understand political representation, therefore, it is important to understand how and under which conditions sexism by voters, media and political parties, actual and anticipated, can lead women candidates to alter campaign behavior and strategies. For the proposed programme of research in TWICEASGOOD, we reconceptualize the “gender penalty” faced by women candidates to take into account the sexism, threats of violence that they face online, through social media, in the traditional media and in face-to-face encounters. We aim to understand the extent of these types of sexism as well as the ways in which women candidates anticipate and counter them, by being “twice as good”, in order to achieve electoral success. To better understand how encounters of “everyday sexism” on the campaign trail, both online and offline and in the media, shape women’s campaign efforts and chances at electoral success, we propose an ambitious five-year programme of research that captures candidate experiences of sexism and assesses their impact on electoral outcomes. To capture how sexism is experienced “everyday” on the campaign trail, we used a mixed-methods approach, bringing together participant-observation of candidates on the campaign trail in four countries with quantitative media analysis, candidate surveys and a battery of items administered in Round 11
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Measuring U-Space Social and Environmental Impact', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The goal of MUSE is to develop a set of key performance indicators, methods and tools for the comprehensive and rigorous assessment of the impact of UAM operations on the liveability and quality of life in European cities, with particular focus on drone-generated noise and visual pollution. This general goal translates into the following specific objectives:1. To define a set of U-Space social and environmental KPIs able to capture the full range of UAM's impacts on citizens’ quality of life with the highest possible level of geographical, temporal, demographic, socioeconomic and behavioural resolution2. To develop new methods and tools for the measurement and forecasting of the proposed KPIs. The new toolset will provide accurate drone 4D trajectory generation in urban areas, modelling of UAM’s noise and visual footprints, high-resolution dynamic population mapping and calculation of population exposure indicators segmented by type of day and time of the day, citizens’ sociodemographic profile, type of activity being performed and other relevant variables.3. To showcase and evaluate the capabilities of the new methods and tools developed by MUSE through their application to a set of case studies in one or more European cities.4. To create the conditions for the transfer of the project results to the subsequent stages of the R&I cycle by outlining a new SESAR Solution, the MUSE U-Space Environmental and Social Impact Assessment Framework, that serves as an enabler of a future U-Space service aimed at optimising the social and environmental performance of UAM operations.


**Keywords:** U-Space, Urban Air Mobility, social acceptance, environmental impact, performance framework, noise, visual pollution, safety, privacy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanism of anti-inflammatory activity of a phospholipid-like drug' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Tumor necrosis factor alfa (TNF alfa) is a key pro-inflammatory cytokine that is produced and released mainly by monocytes and macrophages in response to an infectious organism. Unregulated release of TNF alfa may lead to chronic inflammation in the form o f an auto-immune disease, such as rheumatoid arthritis and Crohn's disease. TNF alfa was also shown to be involved in the development of several other disease states such as sepsis, multiple sclerosis, atherosclerosis, ischemic stroke, inflammation-linked cancer, and diabetes. Several inflammatory diseases are successfully treated by TNF alfa blockers, which are protein drugs and thus suffer from several major disadvantages. Attention in inflammation research has therefore focused on the development of smal l molecular weight inhibitors of TNF alfa production. A phospholipid-like synthetic molecule, ONO 2, was recently found to suppress lipopolysaccharide (LPS)-induced TNF alfa blood level. The mechanism of its activity is currently unknown. Since no endogeno us phospholipids are yet known to inhibit TNF alfa? production, we hypothesize that ONO 2 suppresses TNF alfa? via a novel pathway. The objective of the proposed research is to elucidate that TNF alfa modulating pathway. Specific aims are identification of the signaling components involved in ONO 2-mediated TNF alfa suppression, including: 1) A putative phospholipid-binding receptor and its endogenous ligand.2) Second messengers and early signaling events at the cell membrane. 3) Intracellular ONO 2-regulat ed signaling proteins.We expect that the information obtained by the proposed study will deepen our understanding of the molecular mechanisms which regulate TNF alfa production and will provide us with insights into how to interfere with this process, in order
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Impact of Proteasome Subpopulations on Cardiac Remodeling', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Heart disease is the number one cause of death in Europe and the world. Cardiac remodeling involving cardiac hypertrophy is associated with higher morbidity as well as mortality due to heart disease. Cardiac muscle mass is potentially influenced by the ubiquitin proteasome system (UPS). At the heart of the UPS is the proteasome, which specifically degrades targeted proteins into peptides. The candidate has identified that the cardiac proteasomal core, the 20S proteasome, is a heterogenic group of highly similar multiprotein complexes with different functionality. During the development of cardiac hypertrophy, the assembly and thus the composition of 20S proteasome complexes is distinctly regulated. In consequence, proteasomal activities change non-uniformly. The objective of the proposed study is to analyze the impact of this regulatory mechanism on cardiac remodeling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Deciphering the regulatory T cell repertoire: towards biomarkers and biotherapies for autoimmune diseases'.

assistant: **Innovation**

The discovery of regulatory T cells (Tregs) is a breakthrough in immunology: it revolutionises our understanding of autoimmune disease (AID) pathophysiology and treatment opportunities. Treg numbers or function is defective in most mouse and human AIDs and their restoration induces clinical improvement, as we recently showed using low-dose IL-2 to induce Tregs in patients with AID.The TRiPoD project is based on 3 well supported assertions:- Tregs have huge therapeutic potential- Deep understanding of the Treg T cell receptor (TCR) repertoire is key to exploiting this potential- Deep sequencing technologies required for this purpose have come of ageTRiPoD aims (i) to decipher the Treg repertoire against insulin and myelin at high resolution, (ii) to discover biomarkers for AIDs, and (iii) to develop therapies based on engineered Tregs.Deep sequencing of TCRs from insulin- and myelin-specific Tregs generated in vitro will identify dominant TCRs and antigen-specific Treg signatures. These will be analysed during thymocyte differentiation, at steady state and during disease progression, in mice and humans. Their potential as biomarkers (e.g. a Treg TCR specific for insulin for monitoring type 1 diabetes [T1D]) will be tested in experimental models and in clinical trials of IL-2 in T1D and multiple sclerosis (MS).We will also generate antigen-specific Tregs expressing the dominant TCRs and investigate their therapeutic properties.Ultimately, TRiPoD will contribute to a better understanding of the pathophysiology of T1D and MS, identify novel biomarkers for the follow-up of patients at high risk of, or with T1D or MS, and generate novel therapeutics for clinical development.More generally, our results and new approaches developed in TRiPoD should pioneer biomarker discovery a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The impact of diet abrasiveness on tooth wear' (W-TOOTH) under Seventh Framework.

assistant: **Objectives**

This project combines different analyses of dental morphology with experimental animal husbandry to improve both the ability of palaeontologists to reconstruct past environments and to improve the welfare of ungulates in captivity.  Specifically, this project will test the effect of different diets on tooth morphology and wear (both in terms of changes in tooth shape, and in terms of absolute dental tissue loss) using experimental data that are rarely available for dental research. Tooth data will be obtained from feeding trial experiments of a model animal, the goat (Capra hircus), and from wild and captive individuals of giraffe and black rhino. These will be used to quantify tooth wear at different time scales and resolutions. We will employ geometric morphometrics and the mesowear method to CT scan of the goat teeth. On the same specimens, microtexture analysis will be used to quantify tooth wear at small spatial resolution (tooth facets). We will increase degrees of abrasiveness in the food, a key difference in mammalian diets in moist and arid climates, to help unravel the mechanism of tooth wear in relation to diet on herbivorous mammals. Faecal silica will also be analysed to provide a quantitative proxy for diet abrasiveness in experimental goats as well as other captive ungulates. This project also aims to link experimental results on tooth wear with the care of domestic and captive animals. We will focus on the giraffe and the black rhino to determine whether excessive or unusual wear in captive specimens is the result of improper dietary rations.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Qubit applications' (QAP).

assistant: **Concept**

We will focus our work on qubit applications that are based on physically realized photonic, atomic and solid-state systems. We will design, build and operate quantum memories that allow us to store and deterministically retrieve information encoded in quantum systems.We will develop scalable quantum networks and operational prototypes of quantum repeaters that would allow us to transmit quantum entanglement over large distances (even in a free space the ultimate goal is to design prototypes for satellite communications based on quantum entanglement). Utilizing quantum entanglement between polarization states of photons we will develop feasible quantum measurement techniques in biophysics, life sciences and optoelectronics.We will develop operational demonstrations of efficient control of dynamics of few-qubit quantum systems. These systems will be employed for performing quantum simulations. We will develop a commercial product, a toolkit for the demonstration of entanglement, for use in laboratory courses at Universities. On one side theoretical studies will stimulate experimental investigations and will serve for a detailed description of a given experimental situation. We will also develop new quantum algorithms and protocols for quantum commerce. We will develop benchmarks for testing quantum systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Simple sequence repeats - ssrs - in relation to adaptation in wild barley' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content This is an exciting and innovative project in which I have the opportunity to extend my training and knowledge in the application of molecular markers to the genetics of plant adaptation. The ability of simple sequence repeats to open up genomes has revolutionised research in human and mammalian genetics and will have considerable impact in the plant sciences. This project aims to exploit the recent development of SSRs in barley, to select a set of SSRs which show even genome coverage, and to apply these in genetic characterisation of a set of wild barley populations, for which between and within ecogeographic data are available. The aim being to find markers for genes associated with adaptation, and to examine whether SSRs are biologically neutral. A comparison of synteny between wild and cultivated barley responses to stress will be carried out by experimental testing of barley doubled haploid populations derived from cultivated/cultivated, cultivated/wild and wild/tild crotses. Training content (objective, benefit and expected impact) I will receive training in the development, mapping and hands-on analyses of SSRs. Experimental data will be analysed using various statistical programmes for which formal training is given this will involve analysis of variance and regression, principal co-ordinates and principal components. Appropriate programmes will be used for genetic mapping of SSRs and mapping phenotypic/quantitative trait loci data. I will receive training in hydroponics and cold chamber experiments in examining various physiological responses to imposed stresses. I will produce a doubled haploid population from a wild barley/wild barley cross using the recent published isolated barley microspore protocol. I will be working in a m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Conques in the Global World. Transferring Knowledge: from Material to Immaterial Heritage' (CONQUES) targeting Horizon 2020.

assistant: **Abstract**

Conques is visited annually by thousands of tourists and walking pilgrims. It is a unique site of cultural heritage preserving outstanding visual, material, and ritual cultures from the 9th to the 21st c. Regretfully, its cultural significance contrasts with the lack of comprehensive scholarly attention. Its date, level of reconstruction, and place in the story of the history of art have all been disputed. This is alarming, since a complex understanding of this unique site is indispensable for both the effective research of scientific communities and the expansion of interest among public audiences. The CONQUES project emerges from an ongoing story of exchanges and interactions between scholars, institutions, and fields of research. The overall goal of CONQUES is to promote the first interdisciplinary integrative research on the site, combining the expertise from five different fields, and thus to increase its currently marginal role in public discourse. Our aim is to reconstruct crucial elements in the development of European culture through investigating major stages in the medieval construction of Conques, but also to reimagine and tell the story of the 19th and 20th century “re-invention” of the European Middle Ages.We will break new ground in different disciplines by employing both classic and experimental methods. The key outcomes of this integrative analysis will include: a) a long overdue scientific monograph; b) the creation of a sustainable collaborative research platform working at the crossroads of different disciplines; c) an integrative protocol of research, which will be transferable and exploitable on other sites of the shared medieval European culture; d) the creation of a sustainable public outreach program sharing the results of this multidisciplinary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of new and cost effective methods for non-invasive diagnosis of human pathogens' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Infectious diseases continue to be a serious burden around the world, in both developing and industrialised countries.The present reality is that public health and medical communities are inadequately prepared. We must do more to improve our ability to prevent, detect, and control emerging, as well as resurging, microbial threats to health. The main objective of DIAGNOSIS is to contribute to the above need by developing a novel easy to use, low cost mostly non invasive biotechnological platform for infectious diseases detection. The challenging aim is to reach a short and efficient sample treatment implemented into existing and newly developed portable PCR laboratory for multiplex fluorescent pathogen detection. The concept will be proven on human critical pathogens but will be applicable also for animals, and plants pathogens. The concept will be applicable for samples taken from affected organisms as well as from food/feed and environments (water, air, soil etc.) and has an articulate impact for the biodefense research.The S&T objectives include : i) new principles of nucleic acids sorption/desorption, ii) innovative concentrating methods and materials for the enrichment of viruses, micro-organisms and nucleic acids, iii) adaptation of the phosphoramidite chemistry to alternative fluorescence dyes in order to broaden the labelling assortment for multiplex PCR analyses, a portable non-dependent on external power supply PCR laboratory, and iv) the exemplary demonstration of the whole technological chain on three groups of human pathogens: the Mycobacterium complex, the periodontitis pathogens, and the causal agents of uro-genital diseases, completed by the diagnosis of main representatives of food- and air-born pathogens.