RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Attosecond Coherent Control' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

During the last decade, the advent of reliable lasers capable of producing  pulses of light with duration of merely a few femtoseconds brought on a revolution not only in laser physics but in many other fields of science as well. The next step is to controllably produce pulses with duration in the attosecond regime. Attosecond technology is expected to lead to numerous applications in atomic and molecular physics and in material and surface science.   The goal of this project is to improve the control of attosecond pulse generation, and to use this improved control to study coherent control of ionization dynamics in gases. In order to do this, an upgrade to the existing laser setup at Lund University is needed. Therefore, the first objective is to install a new state-of-the-art laser system for the production of attosecond pulses.  The second objective is to use the new system to produce stable attosecond pulse trains where the number of pulses in the trains can be varied from about ten down to a single isolated pulse. Such control is beyond that what is currently available anywhere and is unique to this work.   Very recently, using attosecond pulse trains centred below the ionization threshold of helium atoms, the Lund group observed a strong modulation of the ionization signal on an attosecond time scale. The depth of modulation depended on the separation between the attosecond pulses as well as on the number of the pulses in the pulse train. In the third objective of this proposal, the newly added control of the pulse trains will be used to study this very recent development further. The vision is to enable control of a broad range of ionization, excitation and dissociation processes in atoms, molecules and more complex systems by directly affecting the electronic mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeting the circadian clock in personalized disease prevention' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Virtually every cell of our body follows the 24-hr ‘circadian’ rhythm of a hypothalamic master pacemaker that evolved in the natural light-dark cycle. Decoding this circadian clock culminated in the Nobel Prize in Physiology or Medicine 2017 for the discovery of molecular mechanisms controlling the circadian rhythm. It is now recognized that a strong, unperturbed circadian clock is a hallmark of healthy aging. The introduction of electric light, however, presents unique challenges: today, 20% of the global work force engages in alternate working hours associated with light in unnatural times. Increases in the risk of major chronic disease and mortality have been associated with night work. Further, night-activity is widespread also outside of work, implicating potential risk for many. This project targets the urgency of alleviating adverse health consequences of a perturbed clock. It does so by aiming to decipher individual risk and related mechanisms 1) using a cutting-edge multi-polygenic score approach; 2) employing transgenerational, deeply phenotyped cohort approaches; and 3) carrying out interventions using genetic risk stratification. This epidemiological project builds on pioneering work of the applicant who conducted the first prospective study to demonstrate significant health effects of chronic clock dysregulation, leading WHO to classify night work as a probable carcinogen. Using transdisciplinary approaches, she implemented field and genetic studies and developed circadian biomarkers, establishing the field circadian epidemiology. Tying the transformative body of her work together, she proposes to take the next ground-breaking leap: To 1) identify the night-active individual who develops disease, 2) profile mechanisms involved, and 3) optimize effectiveness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated Multi-disciplinary Approach to Gain INsight into Endothelial Diversity' under Seventh Framework.

assistant: **Concept**

Endothelial cells (EC) lining the inside of blood/lymphatic vessels in different organs show significant heterogeneity caused by cell-intrinsic and -extrinsic factors. While intrinsic properties are preserved in vitro, EC-extrinsic characteristics are lost upon isolation from the in vivo context. Thus, getting a grasp on EC diversity requires an approach that integrates EC-intrinsic and -extrinsic cues. EC heterogeneity likely forms the basis of vessel-type restricted disorders and may explain the side effects and limited success of ‘broad-spectrum’ (anti-)angiogenic therapies. Also, EC progenitor-based revascularization studies have not asked whether cells acquire the desired EC phenotype once engrafted in diseased tissue where appropriate environmental cues are lacking. Unraveling mechanisms of EC heterogeneity should allow designing tailor-made therapies, which remains the main challenge in curing vessel-related disease. This research program proposes to use an unprecedented integrated in vitro/in vivo multi-disciplinary approach based on stem/progenitor cells and small animal models to: (i) expand our knowledge of EC diversity; (ii) exploit that knowledge to design specialized vascular therapies for (lymph)vascular disorders. In phase 1, gene-profiles (‘blueprints’) will be obtained by micro-array on EC isolated from various organs and macrovessels of different species with (intrinsic blueprint) or without (extrinsic blueprint) further culture. In phase 2, (co-)culture techniques that simulate the in vivo context will be applied to generate EC with the desired blueprint and appropriate function/morphology, by EC differentiation from adult stem cells. In phase 3, information obtained from phase 1/2 will be validated in vivo by (i) testing the expression profile of se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Finance Association Meeting 2001' in the context of a Fifth Framework call.

assistant: **Objectives**

This conference is organised every year by the European Finance Association. It is the main conference in Finance in Europe and it takes place in August in order to foster the participation of U.S. academics.The European Finance Association promotes the development of Finance in Europe. Its annual conference is a meeting point for European academics that benefit from each other different institutional background and thus are able to co-operate.The meeting covers issues on Portfolio Choice, Capital Budgeting, Corporate Govemance, Market Microstructure, Option Pricing, Mutual Funds Performance. Market Segmentation, Venture Capital, Emerging Markets, Bond Pricing and Financial Regulation, among others.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00362-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'IMPACT OF AROMA AND AROMA INTERACTIONS ON SWEET FLAVOR PERCEPTION IN JUICES AND SOFT BEVERAGES' in the context of a Horizon 2020 call.

assistant: **Objectives**

In efforts to help consumers improve their health by reducing their consumption of sugar, salt and fat (Europea 2006/1924/EU), the European Commission recently set new standards for the formulation, production, labeling and advertising of fruit juices (Europea 2012/12/EU). Similar regulations are expected soon for soft drinks. Soft drinks have begun to suffer a poor public image because of their high content of sugar or sugar substitutes, which the beverage industry uses to counteract or mask undesirable flavors. It may be possible to avoid the need to add sugar to fruit juices and soft drinks if we can identify aroma compounds that help the consumer perceive a drink as sweet. Understanding the interaction between aromas allow act on sweetness perceived by the consumer and get drinks with less sugar added.The purpose of the work is to identify aroma compounds responsible for the sensory properties of fruit beverages and analyze how they may affect taste perception (sweet, acid and bitter). Fruit juices and soft drinks will be analyzed in order to characterize the main compounds involved in the perception of aroma as fruity, floral, green and sweet. Close attention will be paid to the chirality of identified compounds in order to study structure-aroma relationships (chemosensory approach). The ability of aroma compounds to interact in influencing taste will also be studied in order to identify synergistic or suppression effects. Moreover, perceptual interactions between aroma and taste will be studied using specific taste compounds. The innovation of the proposed study lies in applying sensory-guided multidimensional chromatographic techniques to beverages, which are complex mixtures of aroma and taste compounds. Aroma compounds will be identified using multidimensional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Organising Fisa and Euradwaste 2022 conference under the French Presidency of the EU Council' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The FISA-EURADWASTE event is a high-level, research policy joint conference on the outcomes and perspectives for the Euratom Research and Training Programme. This 10th edition of the conference will be held in Lyon, France, from May 30 to June 3, 2022, under the auspices of the French Presidency of the Council of the EU, first semester of 2022.The organisers of this conference are:- the Commissariat à l’énergie atomique et aux énergies alternatives (CEA) the most important European research centre in nuclear energy field, and the European Commission (DG-RTD);- with a significant contribution of ANDRA (National agency for the management of radioactive waste), SNETP (Sustainable nuclear energy technological platform), SFEN (French nuclear energy society), and Nuclear Valley.under the control of the Ministry of Ecology, Sustainable Development and Energy (MTES) and in cooperation with the ‘Ministry of Higher Education, Research & Innovation’ (MESRI) and the ‘Ministry for Europe and Foreign Affairs (MEAE).FISA 2022 and EURADWASTE ‘22 conference objectives are:- to present progress and key achievements of the latest projects carried out since 2018 as part of the Euratom Programmes;- to stimulate discussions on the state of play of R&D, key challenges addressed at national, European and international levels on Research and Innovation policies, synergies and partnerships benefitting research and innovation programmes and future perspectives.Expected impacts, thanks to an ambitious communication and dessimination action plan, are:- increasing visibility of the Euratom research and training programme- increasing awareness on nuclear research achievements- networking EU stakeholders- bringing new research project ideas and collaboration between different stakeholders- orienting r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The effect of β-catenin condensation on the Wnt-pathway'.

assistant: **Objectives**

The Wnt-signaling pathway is a key determinant of cell identity and proliferation. However, when aberrantly activated it drives malignant cell proliferation in gastrointestinal cancer, breast cancer, melanoma and leukemia. The key effector protein of the Wnt pathway is β-catenin, which is continuously degraded in unstimulated cells, but in stimulated cells it accumulates and translocates to the nucleus where it activates transcription. A growing body of literature indicates that transcription factors and co-activators interact through the formation of biomolecular condensates. These are membraneless organelles that concentrate and compartmentalise components through weak, but multivalent interactions. Recently, I have shown that β-catenin forms condensates with Mediator co-activator to specifically activate transcription. However, how this new mode of β-catenin interactions influences the rest of the Wnt-pathway is currently unknown. The overarching goal of this proposal is to uncover how β-catenin condensation impacts the Wnt-signaling pathway. I will investigate the consequences of β-catenin condensation for its cytoplasmic regulation by the destruction complex, study how it affects β-catenin co-factor interactions in the nucleus and determine the effect of oncogenic Wnt-signaling on β-catenin condensates. The proposed work will uncover if β-catenin condensation has a function in the Wnt-signaling pathway outside the nucleus, its effect on co-factor interactions and elucidate how it might contribute to cancer etiology. Deeper understanding of the fundamental Wnt-signaling pathway will have a profound impact on our comprehension of embryonic development, adult regeneration and cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structured Analysis of the SMEs Innovation needs based on the Market requirements', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

INASMET had a 50% success rate in identifying SMEs with the potential to work with the CRAFT Programme during FP4. INASMET used an innovative and practical approach, focus in highlighting the real SME business needs and studying how the CRAFT Programme could resolve them. The main objective of this project is to improve and design the new methodology and implement it in three European countries (Spain, France and UK). European project partners will approach SMEs with the new methodology showing them how CRAFT can assist in their business problems and developments. Very good results are expected if the project implementation confirms the success of the new approach. Research Institutions, National CRAFT points and SMEs will have access to the new tool to maximise the European benefits.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Substrate specificity analysis as a key to disclose physiological roles of rhomboid intramembrane proteases.' under Sixth Framework.

assistant: **Concept**

The rhomboids are intramembrane proteases recently discovered in Drosophila where they cleave several growth factors within their transmembrane domains (TMDs) enabling thus their secretion. Rhomboids are conserved across evolution, but their physiological functions remain largely unknown. An efficient method for revealing rhomboid functions is the identification of their substrates. To achieve this goal, I propose two complementary approaches and describe their application to prokaryotic and eukaryotic rhom boids. The first approach relies on a library of chimeric substrates derived from predicted single-TMD proteins from Bacillus subtilis. The library will be screened against B. subtilis rhomboids and mouse rhomboid RHBDL2 in a heterologous cell-based assay. This approach should identify B. subtilis rhomboid substrates and provide insight into the TMD determinants of a rhomboid substrate. The second approach consists in identification of proteins released into the medium by the expression of rhomboid. Extrace llular protein profiles of cell lines expressing either active rhomboid or an inactive rhomboid mutant will be compared and relative protein abundances will be quantified by proteomic methods based on two-dimensional liquid chromatography and mass spectrom etry. This approach has the potential to provide a generic technology for identification of rhomboid substrates, which would have a major impact on the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Compact bio-based thermal energy storage for buildings' in the context of a Horizon 2020 call.

assistant: **Objectives**

Thermal end-uses (space heating, hot tap water, cooling) represent a major part of electricity consumption in Europe and cause consumption peaks, often when electricity is expensive.Hot tap water is the only thermal end-use provided as a base load over a year and that is stored. Space heating and air conditioning are seasonal thermal end-uses with a high residential electricity consumption. They are not stored at the buildings scale to allow peak shaving of the residential electricity consumption. These statements show the interest to develop appropriate thermal energy storages, suitable for buildings, to reduce the electricity bill of end-users. ComBioTES will thus develop a modular compact thermal energy storage (TES) solution for heating, hot tap water and cooling fully adapted for electricity load shifting.A first modular TES will be able to store hot tap water to be converted into ice storage during summer (cooling needs). A second compact latent TES, using high performances (ΔH≈260kJ/kg) bio-based non-aggressive PCM, will store high heating energy amount, for space heating or hot tap water demands. As thermal end-uses in buildings are different regarding seasonal needs, this concept combines the advantage of a modular TES (high utilization rate) with the high volumetric energy density of a latent TES using a bio-based PCM (high compactness: ≥ 100kWh/m3 ΔT=50°C).The ComBioTES consortium and associated External Advisory Board (Idex, Danfoss and Passive House) involve all relevant key players in energy storage and management: RTOs for development and testing infrastructure and SMEs for manufacturing & commercialization of the technology, and representative of potential customers and end users (building owners &operators). In line with IC7, two partners from CHINA (Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PET Imaging of Alpha-Synuclein Fibril Formation' (PET-AlphaSy) under Horizon 2020.

assistant: **Objectives**

Too often, physicians have to rely on a trial and error strategy until the most effective treatment for an individual patient is identified. This leads to a critical loss of time, making the healthcare system ineffective and expensive. In respect to drug development, a high failure rate is apparent at all stages of development and ways to reduce this have high priority for the pharmaceutical industry. To this end, drug development and medicinal treatment need to be more personalized and molecular imaging techniques, in particular Positron Emission Tomography (PET) imaging, can be used to achieve this by 1) evaluating the effectiveness of new treatments emerging from the pharmaceutical industry, 2) improving the ability to diagnose diseases, and 3) aid tailoring the treatment based on individual patient pathology. A limiting factor to develop new effective PET imaging probes is the insufficient number of radiopharmaceutical scientists presently available. Our consortium has assembled 6 radiopharmaceutical frontline academic and 10 non-academic partners to address this problem and train the next generation of radiopharmaceutical scientists. Our training will be focused on an unmet scientific need for Parkinson’s Disease (PD). Fibril formation of protein α-synuclein is thought to be the hallmark for PD, but presently, there are no validated PET tracers available for visualization of pathogenic aggregates of this protein. Our scientific goal is to develop such tracer. A successful tracer will have a strong impact on PD-diagnosis and facilitate the development of effective disease modifying treatments. To reach our goals, it is necessary to train our early stage researchers in a highly interdisciplinary fashion spanning from chemistry, over biology, GMP and pharmacy to nucle