RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Stem cell niche and asymmetric division in aging' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Adult stem cells maintain tissues for the life of an organism by balancing regeneration with tissue damage and turnover. Accordingly, the functional decline associated with aging is hypothesized to result from the reduced net stem cell function. Mechanisms that increase stem cell number, maintenance, or function could therefore be used to counter age related tissue damage. Surprisingly, the very properties that set stem cells apart from all other cells have not been studied extensively in the context of aging. I will study whether the stem cell niche, or asymmetric cell division have roles in aging.Stem cells are surrounded by the niche cells that provide stem cells with factors regulating proliferation and differentiation. I have discovered that the intestinal stem cell niche couples stem cell function to the organismal nurient status during Calorie Restriction (CR) and increases stem cell number via a paracrine mechanism. As CR extends the lifespan and inhibits aging related phenotypes in multiple organisms, I will investigate whether niche mediated mechanisms can oppose the functional decline of the aging intestine.Stem cells generate two daughter cells with distinct fates in asymmetric cell division. It is conceivable that stem cells may asymmetrically apportion old and damaged cellular material to the differentiating progeny to secure the stem cell lineage. I have developed a method to address the age dependent apportioning of organelles in cell division, and discovered that the mammary progenitor cells dispose certain organelles age-dependently to the differentiating daughter. I will determine the role of this new mechanism in stem cell biology and aging.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Investigation and development of organic fibre and mineral sludge for horticultural, forestry and reclaimation purposes' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The re-cycling of newspapers produces large quantities of a by-product made up of plant fibre and clay. This project will develop a material from this for improving soil and as an ingredient in composts. At present many composts use peat, which is a non-sustainable practice. This project aims to produce an alternative product that performs as well as peat but uses a free source of basic material. The project will investigate; the use of biocatalysts and microorganisms to degrade the basic material making it suitable for composts. Ways of producing even mixes of balanced composts. Methods of improving soil structure and moisture retention properties on difficult reclamation sites to allow plant establishment in with minimum topsoil. Production of weed suppressants and soil improvers to aid tree establishment in forestry when first planting and after clear felling, especially when whole tree harvesting The market for composts throughout Europe is huge and the proposes would be able to produce and market products for applications including mulches, soil improvers, potting and seeding medium and specialist lightweight composts for hanging baskets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Economy of Pre-Roman Adriatic Communities: amphora production and trade patterns in a changing world'.

assistant: **Objectives**

The proposed EPRAC project focuses on the economy of the Adriatic region during the Pre-Roman periods from time of establishment of Greek settlements in 4th c. BC to consolidation of Roman power toward the end of the last millennium BC. The proposed project focuses on the under-studied eastern Adriatic region and seeks to characterise the nature of trade and interaction between indigenous communities as well as with the Aegean and nearby Italy from 4th till the end of the 2nd c. BC. The objectives of the proposed research project are fourfold. Firstly, to characterize in detail the nature of amphorae production at the sites of Issa and Pharos on the Dalmatian Islands, in southern Croatia, for the first time. This will be compared to amphorae from consumption sites in order to understand the trade patterns and circulation of liquid commodities transported via amphorae. By mapping the scale and direction of movement of amphorae and their goods from these and other more distant sites, the project with shed light on important economic and social developments taking place in this region from the 4th till the 1st c. BC. Key questions in this area include the influence of Issa and Pharos, the extent of participation of Adriatic communities within regional networks and finally, the its degree of contact with the wider Mediterranean. Proposed project will be carried out in seven research activities within four working packages, that will include archaeological and analytical methods in studying amphorae. The project will involve a detailed programme of research and training, theoretical during the attendance of the courses at Institute of Archaeology at UCL and practical hands-on-training in the laboratory within UCL’s Ceramic Technology Research Network. Together with data mana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Buddhism’s Early Spread to Tibet: Dunhuang and the Influence of Sinitic Scriptures'.

assistant: **Innovation**

Modern scholarship follows emic accounts in situating the origins of Tibetan Buddhism squarely in India, tacitly accepting Tibets claim to be heir to the orthodox tradi-tion. This oversimplifies the complex history of Buddhisms two transmissions to Tibet, in the 7th and 11th centuries, elid-ing the formative early contributions of Sinitic sources, principally imparted from the Silk Road oasis of Dunhuang, a crucial locus of interaction between Tibetan and Chinese cultures in the 8th-11th centuries. Manuscripts preserved in the Dunhuang caves evidence this Sino-Tibetan nexus in native compositions and translations from Chinese into Tibetan. Efforts to trace Chinese and Sino-Tibetan influences on the formation of Tibetan Buddhism have been largely impressionistic, but state-of-the-art tools such as Handwritten Text Recognition to digitize manuscripts allow their systematic analysis, and others permit us to identify fingerprints of Tibetan translations from Chinese. BEST will locate scriptures and other materials of Sinitic origin, and trace their impact on Tibetan Buddhism. Starting with an examination of the reasons for the prominence of Dunhuang, we will uncover the conditions permitting the site to become such a multicultural center, cradle to a high level of Buddhist scholarship. Identifying Sinitic sources introduced into Tibet in the early period, we will probe their later importance, challenging the tradition's polemical historiography which represses such recognition. We will produce a historical study addressing the background of Dunhuang's scholastic Buddhist culture, studies of individual Tibetan translations from Chinese, linguistic studies of the Chinese-Tibetan lexical interface, studies on the most prominent Dunhuang monk-translator, Chos grub, investigatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Promoting a JUST transition to GREEN hydrogen in AFRICA' to be submitted under Horizon Europe.

assistant: **Abstract**

Starting from the R&D/Roadmapping experiences (CEA, HySA, STRATH, IRESEN) and tools (JULICH, ARTELYS, IME, UNIGE) of consortium partners as well as the wide network of stakeholders at AU-EU level (thanks to AHP-HYDROGEN EUROPE  relevant support), JUST-GREEN AFRH2ICA aims to develop a GREEN HYDROGEN JUST TRANSITION ROADMAP (based on the analysis of different AU green H2 scenarios analysed at socio-economic-technical level as well as inspired by EU Hydrogen and Just Transition Programmes) also to drive the deployment of future investment and policies in a synergic way between EU-AU. To do so, JUST-GREEN AFRH2ICA will fully involve AU-EU stakeholders also engaging them in a training/capacity building programme (promoted by an UNESCO Chair initiative lead by UNIGE) and stimulating innovation/market opportunities thanks to an open-innovation matchmaking platform (STAM).  JUST GREEN AFRH2ICA aims to develop a GREEN HYDROGEN JUST TRANSITION ROADMAP that would make AU-EU transition pathways to H2 synergic, sustainable (from environmental and social point of view) and avoiding any new EU hydrogen colonization of Africa, but promoting a mutual benefit collaboration of the two continents towards the development of independent and collaborative H2 economies, R&D ecosystem and value chains. JUST GREN AFRH2ICA aims indeed to be the stepping stone of a collaborative H2 roadmap that, based on the analysis of different AU green H2 scenarios analysed at socio-economic-technical level via partners tools (also assessing local resources  RES and water mainly as key for green H2 production) , will also drive future investment and policies as well as the setup of local manufacturing lines. Project final outcome will be a set of 2030-2040-2050 AU roadmaps that, duly aligned with EU ones, will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced Imaging DEtector for targeted Radionuclide therapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Targeted radionuclide therapy (TRT) uses radiopharmaceuticals to selectively deliver radiation to cancerous cells at specific target organs. A precise quantification of the radiation dose delivered to lesions and organs at risk is crucial for improving patient treatment safety and reducing related side effects. Imaging systems play a key role in this task although, in many cases, with sub-optimal performance.Alpha-emitting radionuclides are gaining prominence due to their exceptional cytotoxicity. For them, image-based dosimetry is an unmet need as currently used gamma cameras are not effective in the case of these high energy and low activity emitters.The AIDER project aims at developing a specialized imaging tool based on Compton Camera (CC) technology to improve imaging in TRT and to enable image-based dosimetry in targeted alpha therapy. AIDER will optimize existing CC technology by pushing the limits in the system performance through the integration of cutting-edge detectors and electronics. Monte Carlo simulations will guide the system optimization and the development of advanced image reconstruction codes aimed at paving the way for quantitative imaging and thus extending the use of CCs to dosimetry applications. The system developed will be tested in hospitals at three levels to evaluate its performance: from simple tests with 3D printed phantoms to anthropomorphic phantoms specifically designed to reproduce the distribution of radionuclides in the body, and finally with patients undergoing TRT.The consortium integrates most of the main European experts in CCs from different disciplines, including four academic groups, a research-intensive SME, two hospitals, and a patient association. They will collaborate with a focus on significantly improving image quality a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Biotechnological Process for Manufacturing Cellulosic Products with Added Value'.

assistant: **Objectives**

The effort focuses on developing a novel biotechnology-based process for converting cellulose into a variety of shaped items with high value. The method is based on the scientific innovation of using safe and biodegradable enzymes instead of toxic and hazardous carbon disulphide, CS2; in order to produce cellulose regenerated products. The success is achieved by gathering the understanding of the enzymatic action on cellulose and by exploiting this knowledge for the development work. The technology to be developed has a real potential to entirely eliminate CS2 needed in the current production method, and as a consequence, is regarded as an environmental technology, which helps to improve economic growth by reducing environmental protection costs. The life cycle environmental impact of the end-products (cellulose fibres, films, casings, sponges, and coatings) is also substantially lower as compared to that of the viscose-based products. Furthermore, the new products are able to replace some of the oil-based products, which reduce emission of CO2 and other greenhouse gases. This approach provides a sustainable solution for the European cellulose converting industry to continue and increase the production of cellulose shaped items such as fibres, films, casings, sponges, and coatings in the future in spite of tightening legislation in environmental protection. The process will also be an easy, cheap and safe process to be addressed to SMEs. Small companies could start production and create new jobs. The Biocelsol consortium consists of eight research organisations and universities and nine industrial participants, from which five represent small or medium size enterprises (SMEs). The industrial partners cover whole production chain from raw material to end products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainability impact assessment of eu's economic policies' (SIAP).

assistant: **Concept**

The purpose of the proposal is to organise a workshop on the Sustainability Impact Assessment (SIA) of EU's economic policies, applied to trade liberalisation as a case study. The objective is to establish contacts between the scientific community members working on SIA-related topics, policy-makers and negotiators. It will provide information to the policy-makers on the state of the art; identify the main European research groups working on the subject, and help academics to understand the policy needs. The workshop will focus on the methodological and analytical aspects of SIA. The use of CGEM linked to sectorial models will be thoroughly explored. The three dimensions of sustainable development - economic, social and environmental - will be covered.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Decomposition of pain into celltypes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Almost 20% of the population has an ongoing pain problem. Pain is caused by a complex recruitment of different types of sensory neurons with different response-profiles and hence, the integrated response of an assembly of different neuronal types results in pain. Due to technical limitations, a system-wide approach to resolve the complexity of cell types and their involvement in the development of pain has yet not been tried.PainCells will first identify and classify sensory neuron types by single-cell RNA seq in rodent and non-human primate. Based on the new classification we will determine the cellular basis for transduction of somatic sensation by developing enabling technologies allowing an activity-based Cre-dependent permanent labeling and identification by RNA-seq the exact cell types and hence, also neuronal assemblies active during particular types of pain. These assemblies will thereafter be silenced, ablated or artificially activated to functionally determine the role of these circuits in pain disorders. This work will for the first time reveal the full complexity of different cell types engaged in particular types of pain and unravel by activity-based  mouse genetics the role of that these play in pain disorders. Thus, PainCells will reveal system-wide principles of coding pain in the nervous system.PainCells will also address the role of terminal glial cells in the skin. This ignored cell type has in preliminary results been shown to respond to and transmit painful stimuli to primary sensory neurons. We will ascertain the role of terminal glial cells in the skin as pain initiating cells and in pain disorders. The discovery that glial cells in addition to sensory neurons represent pain receptive cells should fundamentally change the pain field.Overall, this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Developmental aspects of the neural correlates of episodic encoding'.

assistant: **Innovation**

A central challenge of developmental cognitive neuroscience is to understand how neuroanatomical changes that occur during childhood and adolescence give rise to the development of cognitive abilities during this period. The studies proposed here are the first to investigate explicit episodic memory in a developmental context. Using fMRI, the so-called `subsequent memory¿ paradigm will be employed, in which, while scanned, participants will incidentally encode a series of stimuli, whose classification into remembered" and "forgotten" trials will be made on the basis of a post-scanning recognition test.A comparison of the brain activation pattern associated with these trial types will be conducted in order to identify brain regions that support successful encoding. In adults, levels of neural activation in prefrontal cortical areas (PFC) as well as areas in the medial temporal lobe (MTL) have been observed to correlate with successful encoding. Anatomically, these two brain areas follow a different developmental trajectory, with MTL regions maturing relatively early and PFC regions reaching full maturation only in adolescence.Given children's ability to encode as well as adults (under certain circumstances), this raises the question of which neural systems support this ability in the absence of a mature PFC. The proposed studies attempt to create conditions under which, behaviourally, adults and children perform equally well, and then test whether the hypothesized differential engagement of PFC and MTL in memory encoding in adults and children is (a) observed, and (b) emerges as a function of specific episodic encoding task and components.This project is a natural continuation of the PhD and postdoctoral training I got at Harvard, and will be fundamental in my integratio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Controlled Organoids transplantation as enabler for regenerative medicine translation' in the context of a Horizon 2020 call.

assistant: **Objectives**

End-stage liver failure is a major healthcare challenge. Liver diseases account for approximately 2 million deaths per year worldwide. Liver transplantation is the most effective way to re-establish a liver with normal functions for various diseases including acute liver failure or liver malignancies. Currently, less than 10% of global transplantation needs are met and the gap between patients on transplant waiting lists and available donor organs is steadily increasing. ORGANTRANS proposes a disruptive alternative to donor organs for patients with chronic or end-stage liver diseases who have still to isolate autologous liver stem cells. Driven by a need of leading European transplant centers, ORGANTRANS will tackle current obstacles for liver regenerative medicine by combining advanced know-how in cell biology, biomaterials, bioengineering, automation, standardization and clinical translation.ORGANTRANS will develop a liver tissue printing platform that will be shortly deployed under the “compassionate use exemption” by three leading European transplant centers belonging to the consortium or the External Advisory Board. ORGANTRANS will not only deliver an ATMP, but also platform technologies that can be scaled to other organ systems, as organoid technology is one of the largest parts of regenerative medicine.  The project covers the entire value chain (from cell source, tissue engineering, bioprinting, post-processing to testing) allowing for early adoption of its results (product & process) in clinical practice. The platform will first be scaled to Europe and then to the rest of the world.


**Keywords:** Tissue engineering, liver, 3D bioprinting, ATMP