RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Exploring new genetic causes and pathological mechanisms of epileptic focal cortical dysplasia' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Focal cortical dysplasia (FCD) is a rare, genetic, non-syndromic developmental malformation of the cerebral cortex that accounts for 5-10% of patients with focal epilepsy. FCD represents the main cause of pharmacologically intractable epilepsy, the only treatment available consisting of invasive surgical resection of the epileptogenic zone, which results effective in only 62% of patients. Thus, a better understanding of this disorder is necessary to develop more effective and less invasive treatments. FCD type 2 (FCD2) is an mTORopathy caused by genetic mutations that cause hyperactivation of the mTOR pathway, leading to abnormal cell size (cytomegalic dysmorphic neurons and balloon cells) and disruption of the structure of the cortex. Recently, the supervisor S. Baulac and others have partially explained the focal nature of the disorder by identifying post-zygotic somatic (mosaic) mutations in a percentage of cells that correlates with the size of the lesion. Despite this, the underling genetics remains unknown for ~40% of FCD2 patients. My first objective is to perform deep whole-exome sequencing of a cohort of 60 unsolved FCD2 cases to explore alternative pathways and find possibly pathogenic variants, focusing on those with an established link with mTOR pathway and/or neurodevelopment. Abnormal cells found in FCD2 lesions have been hypothesized as the source of the epileptogenic activity. However, the developmental origins of these cells are still unclear, and there is a need to find clear biomarkers that can clarify the link between mTOR hyperactivation and neuronal hyperexcitability. This project aims to clarify these aspects by applying my expertise in single cell genomics and S. Baulac’s expertise in functional studies and disease modelling in human brain organo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Genetic analysis of olfactory processing and function' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

I am interested in the neural basis of stimulus-driven behaviors. I propose a combination of molecular genetic, in vivo imaging and behavioral approaches to understand the neural processing of olfactory information in the mouse brain.Smell is an essential sense that allows animals to detect food, predators and mates. Olfactory stimuli are recognized by odorant receptors expressed in sensory neurons in the nose. Individual sensory neurons express one of 1300 receptor genes and neurons expressing a given receptor project to a single synaptic structure, called glomerulus, in the olfactory bulb. The patterns of axonal projections are spatially invariant and provide a topographic map of odorant receptor activation in the brain. Information encoded by glomerular activity is transmitted by olfactory bulb projection neurons to several higher olfactory centers in the cortex. Sensory processing at these higher olfactory centers is thought to link odor representations to appropriate behaviors.Central to understanding olfactory processing is the elucidation of the functional properties of the underlying neural circuits. In an effort to address this fundamental problem in sensory biology, I have altered the patterns of neural activity evoked by odors, by generating transgenic mice in which 95% of all sensory neurons express the same receptor. In vivo imaging and behavioral analyses of these mice suggest a model of olfactory processing in which the recognition of patterns of neural activity, or contrast, is critical for odor detection. To test this model, I will exploit a set of defined genetic perturbations I have created in transgenic mice which alter the expression of odorant receptor genes. I will employ state-of-the-art imaging approaches to reveal how genetically defined patter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MyPal: Fostering Palliative Care of Adults and Children with Cancer through Advanced Patient Reported Outcome Systems' in the context of a Horizon 2020 call.

assistant: **Objectives**

MyPal aims to foster early palliative care for cancer patients by leveraging patient reported outcome (PRO) systems through their adaptation to the personal needs of the cancer patient and his/her caregiver(s). Through this intervention, MyPal aspires to empower cancer patients (and their family members) in capturing more accurately their conditions, communicate them with a seamless and effective way to their healthcare providers and, ultimately, foster the time for action through the rapid identification of important deviations in the patient’s state and QoL. Providing this information in a timely and comprehensive manner throughout the disease course will reinforce the potential for applying a patient-centred and integrated palliative care approach for cancer with the participation of all relevant healthcare providers (i.e. oncologists, specialized physicians, psychologists, nurses), which is necessary to cope with the specific disease. In order to accomplish its mission, MyPal will exploit technological advances on digital health to support patients, family members and healthcare providers in gaining value through this systematic and comprehensive PRO-based intervention. Overall, the foreseen advancement through MyPal reflects a paradigm shift from passive patient reporting based on conventional PRO approaches to active patient engagement and a closed-loop approach (bridging the gap between patient reporting and effective actions by healthcare providers to meet the varying patient needs) for coping with palliative care challenges in cancer. MyPal will demonstrate and validate the proposed intervention in two clinical studies, an RCT for adults with hematologic cancers and an observational study for children suffering from solid tumors and hematologic malignancies, he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Low cost energy efficient Pv-ventilation in retrofit housing'.

assistant: **Objectives**

The objective of the proposed project is to research, develop and test low cost high efficiency PV-powered ventilation systems for apartment blocks where PV-modules are integrated in an architectural acceptable way in facades gables and roofs. It is proposed to focus on potentially cost effective building integrated amorphous PV-modules and combine this with an improved version of a shared energy efficient ventilation system with a counterflow heat recovery unit which has reached a further reduction of the electricity use from using fans with DC-motors. Initial research and development activities will focus on the following subjects: Optimised link between PV-modules and fans with DC-motors. Low cost PV-modules for building integration including high reliability and optimised cabling. Modification of standard a-Si modules with proper framimg for retrofit cladding, inclusive cost effective mounting system and combined with non-PV cladding. Improved heat recovery ventilation systems with reduced pressure loss and electricity use based on advanced computer calculations and improved air to air counter flow heat exchanger. Improved control system for DC-ventilation with printcard which has combined transformer!inverter and control function and is placed in air stream. Focus on optimisation in general on DC-motor ventilation fans. Basic development work concerning building integration of PV. After the initial R&D work and tests in the laboratory it is proposed to develop and test the following proto-types of innovative economically optimised PV-Powered energy efficient ventilation systems: 1. An energy efficient shared ventilation system with heat recovery and direct PV-supply to fans with DC-motors (3 m2 amorphous PV-modules per apartment). 2. 3 types of multifunctional sola
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of new systems for a cost effective application of adi in sme foundries' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

It is now completely assumed that strong reliable variations are observed between the ADI heat treatment parameters and the answer to NDE, especially Eddy Currents and Barkhausen Noise measurements. On the other hand, conventional techniques (ultra-sonic propagation velocity and Young's modulus measurements) are too much sensible to graphite structure to provide any reliable information about the matrix structure.Pulsed eddy current measurements give a global response, which depends on the variations of conductivity and permeability with the microstructure.Magnetic Barkhausen noise measurements, can be used to characterise microstructure. Each type of micro-structural constituent exhibit typical signature. So, unexpected constituents can be detected (ferrite, pearlite, martensite...) and ADI microstructure can be characterised.The peak position is especially sensitive to the type of ausferrite which mainly depends on austempering temperature, the peak amplitude is linked to austempering time and is also influenced by the other parameters (Austenitisation temperature and composition).The prediction of microstructure (upper or lower bainite) and (knowing the composition) of the heat treatment parameters has been done on the industrial test bars. Micrographic study and information obtained from heat-treatment performers confirm these predictions.Multi-frequency eddy current measurements (with up to ten test frequencies and harmonic analysis) allow optimum sorting of complex ADI structures. The technique enables Austempered Ductile Irons to be ranked in order of hardness. For a given chemical composition, the eddy current response is sensitive to changes in the heat treatment variables. However similar eddy current responses can be given by different combinations of heat tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Gravitational Waves from Strings with Adaptive Mesh Refinement'.

assistant: **Objectives**

Cosmic strings are motivated by simple extensions to the Standard Model of particle physics (BSM), including dark matter axion models (axion cosmology), superstring theory and grand unified theories. If present, cosmic strings will radiate gravitational waves (GWs) which could be detected by current and future GW experiments, such as LIGO-Virgo-KAGRA (LVK), LISA and the Einstein Telescope. Detection or bounds placed on cosmic strings provide deep insight into BSM particle physics models, and are a potential discovery channel for new fundamental fields.Searches for cosmic strings in LVK data have to date used analytic waveforms predicted using the Nambu-Goto (NG) approximation. This is problematic, as the NG model is known to be inaccurate in precisely the high-curvature regions from which the strongest GW signals are emitted. These waveforms have never been verified by numerical simulation, so current matched template searches may not provide useful information or constraints. GWStrings will address this by producing the first waveforms for cosmic string cusp configurations in full numerical relativity (NR) and using them to perform a matched template search in the LVK data. GWStrings will also match these waveforms to current analytic models to determine their validity. Simulations will be implemented using the adaptive mesh refinement (AMR) NR code, GRChombo.GWStrings will require crucial input from researchers in two key areas: theoretical understanding of fundamental fields in the strong gravity regime, and GW source modelling and data analysis. The first will be provided through a secondment at Sapienza University of Rome in the world-leading gravity theory group of Prof Paulo Pani. The second will be provided by the HECAP group at ICTP, the host institute, whose f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'PROCESSING TECHNOLOGY FOR RECOVERY OF RECOMBINANT ANTIBODY PRODUCED IN CROP PLANTS' (1994-1998).

assistant: **Innovation**

The project is concerned with the discovery and design of stable peptides as biding ligands for antibodies and to produce stable affinity media for the efficient purificationof recombinant antibody produced in plants.The intention is not to use whole or even fragmented antigen on the affinity surface but rather to use small stable peptides which mimic the natural epitope recognised by the antibody. The idealligand will allow controlled capture and release during processing thereby yielding purified active antibody.The project focuses on this extraction process because the effectiveness of downstream activities are crucial to the vision of low cost production of antibody fragments as fine chemicals produced by agricultural technology.The objectives of the project are :- to develop and scale-up antibody purification processes that exploit the antibody's inherent ability to bind its epitope, for maximum recovery of active material from plant tissues;- to devise specific affinity purification media, based on peptide antigen analogues designed to capture and release antibodies, in a stable and multiple re-useable  system;- to transfect genes of appropriately designed antibodies into tobacco and potato (production organisms), to provide material on a practical scale for process development;- to develop process control and product QC techniques to quantify, monitor and  validate the production and purification processes;- to integrate plant culture and harvesting with tissue extraction and affinity processing to develop and define a scale-up pilot process;- to evaluate the performance characteristics of the working pilot system in terms  of active product yield, reusability/stability of immobilised peptide, cost efficiency  and ease of further scale-up.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Model-based Generation of Tests for Dependable Embedded Systems'.

assistant: **Innovation**

MOGENTES aims at significantly enhancing testing and verification of dependable embedded systems by means of automated generation of test-cases relying on development of new approaches as well as innovative integration of state-of-the-art techniques. Driven by the needs of its industrial partners, it will address both testing of non-functional issues like reliability, by e.g. system stress and overload tests, and functional safety tests, meeting the requirements of standards such as IEC 61508, ISO WD 26262, or AUTOSAR. MOGENTES will demonstrate that different domains with a wide variety of requirements can significantly benefit from a common model-based approach for achieving automated generation of efficient test-cases and for verifying system safety correctness using formal methods and fault injection, as this approach increases system development productivity while achieving predictable system dependability properties. For that purpose, proof-of-concept demonstrations will show the applicability of the developed technologies in two application domains: railway and automotive.In particular, MOGENTES aims at the application of these technologies in large industrial systems, simultaneously enabling application domain experts (with rather little knowledge and experience in usage of formal methods) to use them with minimal learning effort. All in all, MOGENTES will increase knowledge and develop new techniques and tools in the area of verification and validation of dependable embedded systems which can be applied in model-based development processes also by non-experts in formal methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Metallic phase change material-composites for Thermal Energy management' (M-TES).

assistant: **Innovation**

Thermal Energy Storage (TES) systems can give strategic contribution to efficiency and flexibility of intermittent power sources of various nature, but their temporal modulation up to long charge-discharge cycles passes through proper tuning of thermal properties of the materials exchanging heat with fluids in TES systems. M-TES project proposes an innovative approach to manufacture by a low-cost one step process, granules of composite metallic Phase Change Materials, m-PCMs. They can be tailored in term of enthalpy-temperature relationships and heat transfer properties to meet the material requirement for flexible TES systems. The 3-year M-TES project will be focused on immiscible alloy systems based on recycled Al-Si casting alloys and Sn, with no need of Critical Raw Material, adding a new option for re-use and recycle them. M-TES project will: (I) identify thermophysical requirements for m-PCMs service, (II) study alloys surface and wetting properties to support the (III) study of suitable process conditions, (iv) obtain thermal/mechanical granule properties. A grained system will be tested as proof-of-concept, and (VI) its mechanical and heat transfer potential will be modeled to support further development, toward higher TRL and other alloys. The multidisciplinary project objectives will be accomplished thanks to the knowledge/equipment complementarity of partners: POLIMI, CNR, KIT, OVGU. They will work in strict interaction within and between WPs. The young researchers hired for the project will be forged to curious multidisciplinary and deep understanding. M-TES dissemination plan will spread results preferring open activities, starting from scientific papers/conferences, widening to open science events for technicians/PhD students, up to the general public.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'General Conference of the European Physical Society, Budapest, 26-30 August 2002'.

assistant: **Innovation**

EPS-2002 is Europe's only broad based multibranch physics conference. It brings together about 600 physicists from all over Europe. Leading scientists in their own fields take the time to explain to their colleagues from other branches the state of the art in physics research. Fields covered reflect some of physics' hottest topics. Plenary sessions are devoted to topics of general interest. Each of the fifteen Divisions and Groups of the European Physical Society (EPS) will organise parallel sessions. The fact that EPS unifies physical societies of 36 European Nations wich, along with Divisions, Groups and Sections make suggestions for Keynote Lecturers ensures a proper representation of the most significant scientific results in the Conference Programme.Presentations will probably include the following topics:Double Heterostructures; Preferential growth and scaling in network systems; Nanostructures, Information technologies in physics; Electrically conducting polymers; Photonic crystals; Inorganic/biological interfaces; The nature of space and time; The Higgs-boson; Localisation of light; Chaos synchronisation; Magnet technology in the age of superconductivity; Percolation and social models; Fundamental forces; Modelling social behaviour on computers; Simulation of earthquakes; The origin of cosmic rays; Nuclear waste transmutation and accelerator driven systems for energy production.