RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The impact of germline metabolic reprogramming on reproduction and physiology', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Animals are composed of multiple tissues with different metabolic needs. During differentiation, the establishment of specific metabolic programs allows cells to acquire specialized functions. The nutrients that fuel these cell-specific metabolic pathways are obtained via the diet. In order to secure proper nutrient supply to these tissues, the central nervous system accesses their metabolic states, allowing the animal to mount behavioral strategies to adapt nutrient appetite. Our understanding of how cell-specific metabolic programs regulate animal physiology and behavior has been hindered by the lack of tractable experimental systems. Using Drosophila melanogaster I uncovered that the germline undergoes metabolic reprogramming, upregulating a specific carbohydrate metabolism branch, the pentose phosphate pathway (PPP) and that oogenesis progression requires the supply of dietary sugars, fueling this pathway. I further showed that the germline communicates its metabolic status to the fat body (FB), regulating the transcription of a satiety factor that acts on the brain to regulate sugar appetite. These findings represent a unique experimental platform, which I will use to study how cell-specific metabolic programs and nutrition regulate whole-animal animal physiology and fertility. I will: 1) identify the transcriptional factors regulating metabolic reprogramming in the germline; 2) test the requirement of specific PPP metabolites in germline cell functions and fertility; and 3) identify the molecules mediating the ovary-FB signaling axis and characterize their impact on FB transcriptional regulation, nutrient appetite, and fertility. Metabolic dysfunctions are known to result in many human conditions. This proposal will not only contribute to our understanding of how
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Effect of ultraviolet radiation on programmed cell death in phytoplankton: impact on biomass cycling and biodiversity' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

As a result of the Individual Marie Curie category-30 awarded to Or. Segovia, we have demonstrated that a genetic cell death programme pathway exists in phytoplankton, triggered when the cells are subject to different stress, but that in normal condition s is silenced. Considering the alarming ozone depletion that our planet is suffering, we propose to simulate the increase in UVB irradiation and examine its effects in cultures of several phytoplankton species, under laboratory and natural solar conditi ons. We will asses the ability of UVB to cause irreversible damage at the cellular level, affecting programmed cell death. The material aim of study will be cultured and short-term (h) exposed to different doses of UVB and simulating natural solar radiat ion with an ORIEL solar simulator which is one of the most important innovations in the study of photo biology. The ORIEL solar simulator simulates the solar spectrum with great accuracy, both for the upper part of the atmosphere and for the different oz one levels. Induction of cell death by UVB will be studied by means of: a) reduction in the number of cells, formation of pyrimidine dimmers, cellular viability, DNA condensation and fragmentation (hallmarks of the cell death process); b) detection of ca spases (proteases involved in the cell death process); c) study nutrient accessibility of the media under UVB radiation; and d) study of changes in CO2 fixation, c) and d) will help us to discriminate whether the effect of UVB on cell death is directly e xerted on the cell death genes or through stress provoked in the nutrient metabolism. This will be of great importance in the prediction of the ecological impact in terms of changes in the structure and functioning of marine ecosystems and processes in th e future, due t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Welfare, redistribution and financial stability in housing and mortgage markets' in the context of a Horizon Europe call.

assistant: **Objectives**

Worldwide, housing wealth represents the most important asset in households' balance sheet, and mortgage debt is the most important liability. In the past two decades, several countries have experienced house price bubbles, excessive households' leverage, and increasing risk-taking behavior of banks. To limit these phenomena, and in response to the 2008 financial crisis, new regulations have been introduced in housing and mortgage markets. The lack of disaggregate and extensive micro level data on housing and mortgages has so far prevented researchers from carefully investigating these events and the effectiveness of regulation. This project will bridge this gap. I will assemble a unique and extensive platform of datasets on housing and mortgage markets, combining disaggregate information on housing transactions, buyers and sellers, and loan level data on mortgages for two European countries, the Netherlands and Norway. These data will be used to develop and estimate novel structural econometric models of demand and supply in housing and mortgage markets. These models will serve to investigate three main questions of concern to policymakers, and to evaluate the welfare effects of existing and alternative regulations via counterfactual simulations. First, I will investigate a novel demand channel of housing and mortgages driven by the rise of accommodation sharing platforms such as Airbnb. While these platforms provide extra income to households renting their property, they also fuel housing bubbles and affect mortgage markets. Second, I will evaluate the role of mortgage securitization in reducing lenders' funding costs, quantify its effect on lenders' risk taking behavior, and propose regulations to balance this trade off. Last, I will document the distributional effec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deformation and fracture instabilities in novel materials and processes' (DEFINO).

assistant: **Innovation**

The proposed RTN on Deformation and Fracture Instabilities in Novel Materials and Processes, is an outgrowth of a previous interdisciplinary TMR network on spatio-temporal instabilities occurring in a variety of materials ranging from soils and rocks to metals and polymers. The goal of the present RTN is to focus only on novel materials and processes with immediate applications to automotive and aerospace industries, manufacturing, microelectronics and surface modification technologies, as well as potential impact to nanotechnology and biotechnology. To this end, the previous TMR partnership is modified to include expertise on interdisciplinary novel materials research and engineering. The research objectives of the proposed RTN are as follows:(i) Develop continuum, stochastic and discrete theoretical and numerical models for describing deformation and fracture instabilities occurring at nano, micro, meso, and macro scales. Fractal and wavelet analyses will be employed for bridging length scales and relating micro to macro response. Novel experiments pertaining to new predictions on pattern formation and size effects in a broad scale spectrum will be conducted. This way a true multiscale modeling approach will be available with all necessary ingredients from theoretical and applied mechanics, materials science and engineering, as well as solid state and nonlinear/statistical physics.(ii) Revisit the PLC and PSB case-studies of deformation instabilities examined in the previous TMR and consider, in addition, multiple shear banding and crack fingering in nanomaterials for settling unresolved issues and calibrating the models developed in (i).(iii) Apply these models to metallic foams, GLARE composites, and nanophase materials. Their implications to forming limit diagrams,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Digital technologies for plant health, early detection, territory surveillance and phytosanitary measures' to be submitted under Horizon Europe.

assistant: **Abstract**

STELLA will develop a real time pest surveillance system. The system will consist of 3 subsystems: 1) an early warning system using novel forecasting models and IoT sensors, 2) a pest detection system using drones, satellites, and a smartphone application, and 3) a pest response system providing data-driven recommendations for containment and counteractive measures. The system will be tested in 6 Use Case Pilots across 5 countries, covering 8 various diseases of importance to the EU. Capacity building activities will be developed with a focus on providing training, education, and resources to farmers, agronomists, and other stakeholders involved in crop protection. These activities will aim to equip stakeholders with the skills and knowledge necessary to effectively use the STELLA system and implement environmentally friendly crop protection alternatives. Policy recommendations generated by the project will aim to support the European Commission's goals of reducing pesticide use and managing priority plant pest outbreaks. The recommendations will be based on the data and insights gathered through the early warning, detection, and response system. A networking strategy will be developed to leverage existing knowledge and enable links with relevant organisations, networks, projects, and initiatives. Collaborating with stakeholders as well as other projects will provide opportunities to exchange ideas and learn from others' experiences.


**Keywords:** pest detection, disease modelling, remote sensing, pest surveillance, artificial intelligence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multimodal Verification for Teleservices and Security Applications' (M2VTS) under Fourth Framework.

assistant: **Objectives**

The primary goal of the M2VTS project is to address the issue of secured access to local and centralised services in a multi-media environment. The main objective is to extend the scope of application of network-based services by adding novel and intelligent functionalities, enabled by automatic verification systems combining multimodal strategies (secured access based on speech, image and other information). The objectives are also to show that limitations of individual technologies (speech recognition, speaker verification...) can be overcome by relying on multi-modal decisions (combination or fusion of these technologies) and can find practical and important applications in the new emerging fields of advanced interfaces for tele-services.The main goals of the project are therefore :- to implement and validate secured access schemes welded in existing voice-based services.- to develop new security services exploiting emerging speech and image-based recognition technologies.- to provide secured services on non secured networks (such as PSTN, ISDN, LAN).- to develop new services for security applications (for alarm verification and access control).A flexible software and hardware platform has been realised. From this platform, four demonstrators have been developed, evaluated and installed at end-user sites:Level 1 : A network-based voice mail system with access control using robust speech recognition technology and rejection (one speech modality is used: speaker dependent password recognition)Level 2 : The same application reinforced by two additional modalities (text-dependent and text-independent verification of the voice)1 st Level 3 : An access control to buildings realised using the level 1 system complemented with a profile recognizer2 nd Level 3 : An access cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ExeVir's XVR011, a best in class nanobody-based biology that broadly neutralizes SARS-COV-1 and SARS-COV-2' in the context of a Horizon Europe call.

assistant: **Objectives**

XVR011, ExeVir's clinical lead candidate has emerged from scientific research from labs of highly regarded virologist Xavier Saelens and biochemist Nico Callewaert. Nonclinical data has recently been published in Cell and a preprint on BiorxIV. XVR011 is a nanobody-Fc fusion, has best-in-class potential, neutralizes SARS-CoV-2 and minimizes the development of lung damage in hamsters. The lama-derived single-domain antibodies are smaller than human antibodies and can attach to parts of a virus that are difficult to access for the human immune system. XVR011 inactivates spike proteins and sterically blocks spike binding to ACE2, preventing virus from entering a human cell, stopping viral replication; this supplements the patient's own immune response in a critical time window during which many COVID-19 patient's immune system reacts too slowly, giving it more time to do its job and eliminate the virus. It binds to a unique highly conserved epitope in the viral receptor-binding domain. Its epitope is much less susceptible to human antibody immunity pressure that can lead to viral escape, resulting in retained potency against such escape variants. It thus neutralises the rapidly spreading SARS-CoV-2 variants, and exhibits a unique, wide scope binding across the Sarbecovirus clades. Furthermore, XVR011 has been optimized for stability, safety and manufacturability. XVR011 received approval from the Belgium regulators to move into its Phase 1b. Seven IP patents were filed early on during the pandemic. ExeVir has surrounded itself with both a team of experienced entrepreneurs and is backed by a mix of private and public experienced partners and has a strong board of directors bringing with expertise across the whole value chain. The objectives of this proposal is to demonstrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Flash lamp supported deposition of 3c-sic films'.

assistant: **Innovation**

The growing SiC market requires low cost, high quality and large area SiC wafers due to its outstanding potential for microelectronical and biomedical applications at high temperatures and in harsh environments. Currently, the market is dominated by one US company CREE producing 4/6H-SiC wafers with high cost and low mobility. The FLASiC-project will develop a new process to produce epitaxial and bulk 3C-SiC on Si or SOI substrates. To take advantage of a higher mobility, larger size and lower costs of this new material the defect density has to be reduced by several orders of magnitude. This will be reached by high energy absorption at the heteroepitaxial interface using Flash Lamp Annealing in ms range. The development of basic features of a new SiC-wafer technology is expected as well as contributions to the physical properties of 3C-SiC and the theoretical understanding of the formation process. The success of this project will bring Europe to a leading position on the SiC market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Application of GPS and remote control techniques to improving farm efficiency using wide span' (1994-1998).

assistant: **Innovation**

THE PROJECT INVOLVES THE APPLICATION OF SATELLITE NAVIGATION TECHNIQUES TO THE CONTROL OF WIDE SPAN GANTRY TRACTORS USED IN AGRICULTURE. PRECISION GUIDANCE WILL ENABLE THE FULL BENEFITS OF GANTRY TRACTOR SYSTEMS TO BE REALISED. THESE BENEFITS INCLUDE GREATLY IMPROVED PRODUCTIVITY AND REDUCED FUEL, FERTILISER AND OTHER INPUTS. THE EXPLORATORY STAGE WILL INVOLVE THE SEARCH FOR PARTNERS, RTD PERFORMERS, AND THE DEFINITION OF THE WORK PROGRAMME.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Memory of Motion'.

assistant: **Concept**

What if we could generate complex movements for a robot with any combination of arms and legs interacting with a dynamic environment in real-time? MEMMO has the ambition to create such a motion-generation technology that will revolutionize the motion capabilities of robots and unlock a large range of industrial and service applications. Based on optimal-control theory, we develop a unified yet tractable approach to motion generation for complex robots with arms and legs. The approach relies on three innovative components. 1) a massive amount of pre-computed optimal motions are generated offline and compressed into a ``memory of motion''. 2) these trajectories are recovered during execution and adapted to new situations with real-time model predictive control. This allows generalization to dynamically changing environments. 3) available sensor modalities (vision, inertial, haptic) are exploited for feedback control which goes beyond the basic robot state with a focus on robust and adaptive behavior. To demonstrate the generality of the approach, MEMMO is organized around 3 relevant industrial applications, where MEMMO technologies have a huge innovation potential. For each application, we will demonstrate the proposed technology in relevant industrial or medical environments, following specifications designed by the end-users partners of the project. 1) A high-performance humanoid robot will perform advanced locomotion and industrial tooling tasks in a 1:1 scale demonstrator of a real aircraft assembly. 2) An advanced exoskeleton paired with a paraplegic patient will demonstrate dynamic walking on flat floor, slopes and stairs, in a rehabilitation center under medical surveillance. 3) A challenging inspection task in a real construction site will be performed with a quad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Programming cellular networks and community behaviour with synthetic RNA-based devices' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

RiboNets aims at programming cellular networks and community behaviour using newly engineered logical gates that transmit and process information within cells in an innovative way, namely via RNA-based devices.RiboNets wants to develop a newly designed RNA-based toolbox for cellular computing. RNA has three major advantages: (a) RNA turnover is fast thus efficient computing is possible with RNA networks, (b) RNA folding and RNA-RNA interactions can be well predicted, thus, a large number of novel devices can be build, (c) RNA production is energetically cheap, therefore the host cell is not affected by computing. The RiboNet toolbox will be created following a three-step process: (i) rational design and analysis of RNA-based devices on a computer, (ii) selecting best performers in vitro within highly parallel microfluidic reactors and, finally, (iii) integrating and testing them in living cells. The combination of all three layers of analysis, in silico, in vitro and in vivo, is a major point of this proposal. It will allow us to deal with complex regulatory networks and to examine the underlying mechanisms of information transmission and processing within cells.The toolbox developed by RiboNets will provide an outstanding prerequisite for novel designs in synthetic biology and life sciences. The usage of the RiboNet toolbox will result in the creation of RNA-based sensors and RNA-based devices with efficient regulation of engineered metabolic and signalling pathways that will have potential applications in white biotechnology and medicine. For example, RNA-based antibiotics would improve human condition in technological applications, as well as in health, in the future. With RiboNets, a new territory will be explored, shedding light on how RNA networks contribute to ce