RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of natural injectable biodegradable systems based on chitin and its derivatives' (RENEWINJ) targeting Sixth Framework.

assistant: **Abstract**

In this project, we will develop innovative injectable biodegradable systems (IBS) based on chitin for tissue engineering and drug delivery applications. This is a natural-based, renewable and widely available organic polymer. The IBS will consist of the pristine polymer, or one derivative obtained by simple chemical/ enzymatic methods (oligomers, water soluble chitin). These polymers, or a mixture of them, will be subsequently modified by acrylation, thiolation or reductive alkylation in order to make the m capable of in situ hardening in the physiological environment. Innovative approaches will be also tested, in which two systems will be integrated into one single device, by forming a simultaneously gelling-cross-linking system, which uses Michel-type additions to cross-link previously gelled systems.The developed IBS will be further evaluated for controlled release and tissue-engineering (mainly of cartilage) applications, two of the most currently required applications in the biomedical field. An environ mentally friendly approach will be applied in all steps of the research: what means we will try to minimize the amount of synthetic components, energy usage and chemical modification steps needed to accomplish the proposed objectives. Besides the research part, this project also foresees a range of other activities: teaching experience, advising of less-experienced researchers, complementary courses (on ethics, property protection, etc.), improvement of the presentation skills and attendance to conferences, among others.The fellow is expected to get expertise in all topics relevant to research (and not only on the research itself). The final goal will be to prepare him to define his own strategies of action and his personal view of the science, in order to pursue a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Incorporating the extrinsic drivers into fisheries management' to be submitted under Sixth Framework.

assistant: **Abstract**

Traditional single species fisheries management has failed. In part because the single species are part of a wider ecosystem and must be managed in that context. The IN EX FISH project aims to improve the responsiveness of European fisheries management to the anthropogenic and non-anthropogenic factors which affect exploited fish populations. A holistic, ecosystem approach will be used to assess the effects of a range of factors on the main functions of the biological cycle of exploited fish species and the ecosystem that supports them. A comprehensive synthesis of the effects of anthropogenic and non-anthropogenic factors on exploited fish populations will be produced and used for metadata analysis. The relative impact of each factor will be assessed and a ranking produced. The project will use four case studies to integrate this knowledge and develop management schemes. Metrics to measure the status of the environment and several exploited fish species in the North East Atlantic (comprising the North Sea regional advisory council (RAC) area, ICES area VIa and Icelandic Seas), the Baltic Sea RAC area, the West Iberian Sea (within the south-western waters RAC area), and the Mediterranean Sea RAC area will be produced. These will be used to develop a management regime for use in European fisheries management but is sensitive to the fluctuations in environmental quality and state. The IN EX FISH project recognises that humans are part of the marine ecosystem, and that some are dependent upon it for their livelihoods. The project will validate its management recommendations through consultation with stakeholder groups and incorporate their feedback into the project recommendations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Advanced platform for profiling of therapeutic targets and functional analysis of circulating tumour cells in cancer patients'.

assistant: **Concept**

As an alternative to invasive needle biopsies, the analysis of CTCs released by metastatic lesions into the blood has been recently introduced by the PI as “liquid biopsy”.  The molecular analysis of CTCs before and during treatment could supply a real-time status of the landscape of metastatic tumor cell clones in an individual cancer patient. CTCs might reveal representative information on metastatic cells located at different sites because the blood represents a pool of tumor cells potentially released by all lesions in the cancer patients. Moreover, blood samples can be taken sequentially during the course of the disease and therefore allow a real-time assessment of the molecular evolution of the disease with important implications for decision making on cancer therapies. However, despite the obvious potential of CTCs as biomarker, current CTC capture assays require sophisticated, expensive and complex assay systems, which is the most important bottleneck for a more widespread use of CTCs as liquid biopsy. The assay development in the ERC PoC Grant CAPTURE-CTC (end: 11/2016) and the successful research on improved methods for molecular characterization of CTCs in the Advanced Investigator Grant DISSECT (end: 07/2016) of the PI has allowed to develop a novel improved platform for CTC detection. To implement our chip into future clinical decision making, we will now focus on the clinical validation of the chip platform including the development of SOPs as basis for kits for expression of therapeutic targets and resistance mechanisms in CTCs. Moreover, the establishment of transient CTC cultures from chip-isolated tumor cells will foster drug testing in individual cancer patients. In conclusion, the CTCapture_2.0 project will be an important prerequisite for successful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dynamic Origins of MHC class I Selector function', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

DynOMIS aims to elucidate the antigen selection mechanisms of the adaptive immune system at the molecular level in the highly complex cellular environment. Major histocompatibility complex class I molecules (MHC-I) is a key mediator of adaptive immunity, the cell’s arsenal against infectious pathogens and malignant transformations. MHC-I present antigenic peptides to cytotoxic T lymphocytes at the cell surface, which in turn unleash their cytotoxic apparatus only when peptides from non-healthy proteins are recognized.  This process is the result of an equally important peptide selecting function in the early secretory pathway, a mechanism that has not been clearly understood in spite of its fundamental role in vaccination. Deep understanding of the exact mechanisms that drive peptide selection by MHC-I will help to predict immunoprotective epitopes in infections and cancer, which will in turn pave the way for the development of more effective T cell-targeting vaccines and biomarkers to stratify patients’ suitability for immunotherapy.DynOMIS will employ a sophisticated, interdisciplinary approach that integrates quantitative computational systems modelling to identify molecular mechanism from cellular biochemical information, experimental investigation of the structure and dynamics of peptide-bound MHC-I over a large range of timescales, and state-of-the-art molecular dynamics simulations and free energy calculations to elucidate the thermodynamic basis of the peptide selection mechanism in the context of their interactions with cellular cofactors. To this end, DynOMIS will be carried out by an experienced researcher at a world-leading interdisciplinary group comprising molecular immunologists, structural biologists, computational chemists, and industrial partners with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Glycomics for Cancer Precision Medicine' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Breast Cancer is the most commonly diagnosed cancer in Europe and remains the first cause of cancer death in women (nearly 92,000 deaths in 2020). Precision medicine uses data-driven insights to reflect the heterogeneity of patients and improve cancer care by offering actionable oncology treatment options. Tumour tissue heterogeneity is the leading cause for inter-patient variation in treatment response. One of the largest sources of tissue heterogeneity arises from post-translational glycosylation of proteins and aberrant glycosylation is a hallmark of breast and other cancers. Yet, substantial gaps remain in our knowledge of cancer glycans. Glycomics (the comprehensive study of the glycome) offers the potential to provide the global glycosylation status (GlycoMap) of a patient and shed new light on tumour heterogeneity to guide precision medicine. This project aims to address the substantial knowledge gap in breast cancer tumour glycosylation data by developing an integrated glycomics workflow to produce patient-specific 'GlycoMaps'. By including glycosaminoglycan (GAG) 'omics from intact GAGs for the first time, combined with other glycan analyses will enable the generation of Breast Cancer GlycoMaps from resistant and drug-sensitive patient-derived organoids (mini avatars of tumour tissue), defining residual tumour tissue following treatment that causes relapse and metastasis. The mission and design of the GlycoMap project is to train the researcher, who has a background in GAGomics, proteoglycan biology and bioinformatics, with expanded skills and expertise in N-/O-glycomics, organoid culture, hi-resolution 3D imaging and advanced bioinformatics in the context of breast cancer, augmenting her future career opportunities, as well as establishing unbiased top-down in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Industrial and regional valorization of FoF Additive Manufacturing Projects'.

assistant: **Concept**

Additive manufacturing (AM) has been highlighted as a key technology with potential for creating sustainable high value European based employment, addressing societal issues and supporting environmental sustainability. The processes based on Additive Manufacturing spans many industries, including automotive, medical, aeronautics, defense, capital and consumer goods and do-it-yourself concept, energy, etc. AM has demonstrated to possess the capability to generate future revenues, to develop novel disruptive business models, not seen up to date, that could help to keep manufacturing in Europe competing with emergent countries. All those are heavyweight reasons for Europe to make specific efforts to define a plan of action in the field. This strategy should include detail implementation plan defining innovation sectorial chains from design phase to target commercial products. It should define TRL aspect in each link of the chains, type of stakeholders to carry out the tasks, timeline and priorities. Moreover, in order to have a complete success should also involve not only technology stakeholders but also policy makers.On this basis, FoFAM project takes up the challenge of clustering technology developments on AM and place them into defined value chains in lead markets for Europe. The project intends to identify gaps for business development and to attack them with specific actions and timeline. It also includes high involvement of European regions to ensure an efficient use of structural funds associated to them. FoFAM also address not only technological aspects but also aims at identifying other horizontal economical and societal issues that will be taken into consideration to ensure AM industrial deployment. To involve high number of key stakeholders , the project has a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microtubule Dynamics and Protein Trafficking in Axon Regeneration' (MDPTAR).

assistant: **Innovation**

The overall aim of the proposal is to support the scientific career development of an experienced researcher, by completing an interdisciplinary research project on microtubule dynamics in axon regeneration, and enabling the fellow to acquire new knowledge and academic skills in order to attain a position of maturity and independence. The scientific objectives of the research are to analyse how the mechanisms regulating microtubule network dynamics and protein trafficking underlie the intrinsic ability of axons to regenerate after injury with the aim of improving treatment in neurological diseases such as spinal cord injury. The project will enhance the fellow’s scientific curriculum by providing advanced training in innovative and sophisticated techniques. The research training objectives are to contribute to the fellow's writing and publication skills, public presentation of her scientific results, establishment of collaborations and to learn to manage her own scientific project in a multidisciplinary environment. This will enable the fellow to compete for available funds thus, facilitating the possibility of establishing her own independent research line in Europe. The fellow’s mobility from the UK to a leading laboratory at the Erasmus Medical Center in Rotterdam, The Netherlands, will provide new points of view to perform research, scientific exchange and social interaction. This proposal is highly relevant to the 2010 Work Programme because: a) it entails genuine mobility strengthening scientific exchange between European members, b) it will increase the overall competitiveness and excellence of European science in the key field of axon regeneration and c) its innovative nature will further enhance the European Research Area making Europe more attractive to the mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Differentiation of adipose-derived stem cells info cardiomyocytes: Understanding and application' (ADSC-CARDIAC) targeting Sixth Framework.

assistant: **Abstract**

The main objective of the project described in this proposal is to provide a stable framework for the re-integration of a European researcher, who has been conducting academic research in the US for over 5 years, into a European SME. The project will allow the host institution to benefit from the knowledge and experience acquired by the applicant in his previous training and work in Europe and the US. The applicant's strong backgrounds in molecular and cellular biology, as well as developmental biology are as of significant interest to the company.As a result of this action, the applicant will continue his professional activity in his field of expertise in the European Union by conducting the company's stem cell differentiation project. Regarding the scientific content of this proposal, the applicant plans to utilize human adipose derived stroma (stem) cells to search for factors that initiate the differentiation into cardiomyocytes. The in vitro-differentiation of stem cells recapitulates, to our current under standing, the processes that take place during embryogenesis. Cardiac differentiation has been studied in great detail in vertebrates, and the expression of several genes during cardiogenesis delineates distinct developmental phases.We will use the promoters of these genes and couple them to fluorescent markers (GFP) and Luciferase, in order to achieve a qualitative and quantitative read out, respectively. One of the main objectives is to develop with the host SME a cell-based differentiation platform for high throughput screenings. Secondly, we will use a selection marker (puromycin) to obtain pure cardiac and pre-cardiac cell populations, which will be used for DNA-microchip analysis to search for new genes involved in cardiogenesis. The long-term goal i s to t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Seismogenic COmpression in southern Italy? – High-resolution topography (Lidar) and mOrphotectonic analySis to test the active nature of the Southern ApenninE Outer Thrust Front' under Horizon 2020.

assistant: **Concept**

Over the past decade (1999-2009), earthquakes proved to be the deadliest of all European disasters. Italy is one of the most seismically active countries in Europe and, Southern Italy, is recognized as the most seismically active sector of the peninsula. The sector is traversed by the Apennine fold-and-thrust belt which is seismogenic, along the Outer Front, in northern-central Italy and in Sicily. On the contrary, it is considered often inactive in southern Italy. Nevertheless, historical seismicity reports several destructive earthquakes and geological-geomorphological indications of recent deformation have been recently pointed out. The geological setting contrasts the recognition of the seismogenic sources since the Apennine Outer Front is buried under Plio-Quaternary foredeep successions. It is urgent to develop new approaches to investigate the active deformation in this sector. This research aims to detect evidence of Late Quaternary active compressional faulting along the Southern Apennine Outer Front. The peculiar geological setting of the sector necessarily requires a multidisciplinary approach. The research plan envisages the integration of HRT (high resolution topography) data analysis, morphotectonic analysis in GIS/Matlab environments, geochronologic dating and classical methodologies of analysis belonging the seismotectonics. Airborne lidar topographic data are able to capture fault offsets and landscape properties recording the complexity and sensitivity of deformation. The drainage pattern analysis and morphometric indices computed using GIS (Geographic Information System) and Matlab programming language are suitable for evaluating the effects of active tectonics on the topography or morphological features. These novel approaches are exploding worldwide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Geomicrobiology of Parys mine, Wales: Influence of mineralogy on the development, composition and functioning of microbial communities' (PARMIN), addressing dissemination and exploitation.

assistant: **Impact**

The presence and activities of microbes on and within minerals have profound worldwide environmental and economical consequences; from the consumption of atmospheric carbon dioxide during biotically-enhanced weathering of basalt, to the degradation of manmade structures and microbial mineral formation. In metal mineral mines, microbial activities have both positive and negative consequences. Microorganisms reside on minerals, including sulfide ores such as pyrite and chalcopyrite, abundant mine ores in the UK and worldwide. Through microbial metabolism of the iron contained within these ores, sulphuric acid is produced, resulting in an acidic mine environment. Drainage from such mines enter watercourses and wetlands, producing acid mine drainage (AMD). In addition, toxic heavy metals such as lead, are more soluble at a lower pH and are thus usually present in AMD, adding to the environmental concern. While some of the common microbial species found in such mines have been well characterised, there remains significant questions regarding microbial communities as a unit, and their functioning, such as: i) are communities established quickly and do the species within those communities change over time, ii) which species are active and what are they doing, and iii) what effect does mineral chemistry (mineralogy), have on the structure and functioning of the communities. In answering these questions we take a step closer to reducing environmental impacts, through increased awareness of how human activities impact on the microbial activities and the resulting AMD produced. This research will answer the questions outlined above, using Parys mine in Wales, as the study site; a prime example of abandoned metal mines and once the world’s largest producer of copper. Two of the mos