RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New strategies for chemical synthesis: Enantio-selective Organocatalytic Sigmatropic rearrangements' (ORGANOCATALYSIS), addressing dissemination and exploitation.

assistant: **Impact**

The development of synthetic methodology using enantioselective organocatalysis promises the efficient generation of structurally diverse and functionally versatile molecules. The applications of the methodology are wide-ranging and this proposal aims to use enantioselective organocatalysis to address problems in both synthesis and chemical biology. This will offer a multi-disciplinary aspect to the proposed research and in particular we will use the molecular functionality to design cascade reactions for the innovative and rapid synthesis of bioactive natural products. Furthermore enantioselective catalysis can provide ideal building blocks the synthesis of structurally unbiased libraries that can be used to probe biological function or mode of action.Alternatively, a more focussed approach using chemical genetics can be used to investigate biological function through the synthesis of natural product like libraries. We propose to develop an organocatalytic and enantioselective variant of this transformation that precludes the use of strong bases and avoids the competing 1,2-rearrangement and is mediated through the generation of a transient enamine motif via secondary amine catalysis. The use of homochiral substituted secondary amines should lead to the first catalytic enantioselctive sigmatropic rearrangement reaction. The potential applications of this reaction are widespread as the ability to install 2-vicinal stereo-centres embedded amongst up to 3-orthogonally reactive functional groups represents a powerful transformation. Applications to the synthesis of architecturally complex natural products will be investigated that exploit efficacy of the proposed new transformation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Two-point microrheology of heterogeneous langmuir films'.

assistant: **Concept**

On the one hand, microrheology has been a powerful tool since the mid-80's for characterizing 3D viscoelastic materials. On the other hand, the study of soft interfaces has identified several poorly characterized complex systems including low-surface-viscosity Langmuir films and spatially heterogeneous Langmuir films. This proposal represents a merger between these two ideas: we propose to characterize the rheological properties of interfaces, taking into account their full complexity, including adjacent 3D materials, microscopic spatial heterogeneities and nonlinear effects. We will develop and enhance a two-particle surface microrheology, and provide this way new characterizations of these soft interfaces.Using this method, our research objectives include: [1] measuring very low surface viscosities achieved by spreading surfactants (DpPC) at an air/water interface and which are so low that they have not been measured by other techniques. Then, turning to monolayers of proteins (beta-lactoglobulin), we will further extend this technique to viscoelastic membranes and measure surface elasticities. [2] Focusing on heterogeneous monolayers with complex properties. Under surface pressure, surfactants form heterogeneous structures such as liquid expanded and liquid condensed phases to which we will apply our technique to measure length-scale dependent surface viscosities. We will finally measure the flow field and extend a 3D model by Levine and Lubensky to capture the most important features of the rheology of this spatially heterogeneous films. If successful, the model will be able to account for differences between the 1-particle and 2-particle measurements, in other words, reconciling the local and global rheological behavior of the interface.This project provides benchm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Photonic Integrated Circuits using Scattered Waveguide elements in an Adaptive, Reconfigurable Mesh.' (PhotonICSWARM), addressing dissemination and exploitation.

assistant: **Impact**

In PhotonICSWARM, I will use silicon photonics technology to build general-purpose, programmable optical chips that rely on topologies of distributed waveguide circuits governed by distributed control algorithms.In silicon photonics, optical signals are transported along waveguides on photonic integrated circuits and processed by elements that filter specific wavelengths or modulate signals. Silicon photonics is the choice technology for high-speed communication links, but also for different types of sensors. However, photonic circuits are still very simple compared to today's electronics, because they use connectivity topologies where light follows a single path. The optical chip concepts I propose in PhotonICSWARM start from radically different topologies, which will allow 1-2 orders of magnitude scaling in complexity. They are based on tightly interconnected, distributed optical signal paths. This high connectivity will enable much more complex optical functions, and to realise these I will apply adaptive, distributed control algorithms. I will explore different optical waveguide concepts: waveguide meshes, phased arrays, lattices of resonators, lateral leakage and 2-D holographic gratings. These will be fabricated on existing state-of-the-art technology platforms, so PhotonICSWARM will rather revolve around the theory, simulation, design and characterisation methodologies.With these distributed photonic circuits I will create programmable photonics that can be applied for many applications, as the optical equivalent of electronic field-programmable gate arrays (FPGA). They can enable on-chip parallel optical signal processing for pattern recognition or real-time encryption of high-bitrate optical data streams. Programmable circuits can speed up the research cycle, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'COASTAL CLIMATE CORE SERVICES'.

assistant: **Objectives**

Even if climate change mitigation objectives agreed in Paris are met, sea level will rise at least by 0.3 to 0.6m in 2100 and then continue rising for centuries. The potential impacts for coastal flooding are a major source of concern for Europe because many infrastructures are located close to shorelines or in low-lying areas. Broad scale coastal climate services and platforms available today have successfully addressed the need to raise awareness on mitigation. However, an authoritative, consistent and decision oriented platform is still missing to meet the needs of adaptation practitioners concerned with (1) the routine identification of coastal territories at risk from innundation, (2) coastal land use planning or (3) maintaining coastal infastructure services. The Coastal Climate Core Service (CoCliCo) project aims at informing decision-making on coastal risk and adaptation, by delivering an open web-platform exploring dominant risk drivers, adjusting visualisation and analysis techniques to local decision contexts, and combining relevant and high-quality geospatial information layers. Through the platform, users will be able to visualize, download and analyse multiple decision-oriented coastal risk scenarios relevant to the rich user narratives  of our Demonstration Case Studies addressing the three needs raised above. To meet this challenge, CoCliCo brings together European organizations and scholars that have proven track records of delivering broad-scale coastal risk and adaptation assessment, as well as leading research and technologies in interoperable geospatial data management, decision sciences and risk communication.


**Keywords:** sea-level rise, climate change, coastal hazards, coastal vulnerability, coastal infrastructure and buildings, flood, erosion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Initial Training Network on Developmental and Computational Biology' (DEVCOM).

assistant: **Innovation**

The ability to manipulate cellular pluripotency and differentiation holds the as yet unrealized promise of regenerative medicine to produce replacement cells and tissues. To this end a deep understanding of the regulation of differentiation potential in the context of normal embryonic development is crucial. The recent revolution in sequencing technology has enabled high throughput and genome-wide analysis of cellular behaviour. The challenge with the new opportunities in genome-scale quantitative data gathering is to reach a more fundamental, systems level understanding of complex biological phenomena such as development and differentiation.The mission of the DevCom network is to train a new generation of promising scientists to bridge the gap between developmental and computational biology, and to prepare this generation for the emerging field of “New Biology” in which systems-level, quantitative and computational approaches are fully integrated in the analysis of profound scientific problems related to pluripotency and differentiation.  The DevCom research plan revolves around early embryonic regulatory networks and disease networks in vertebrate embryos of the Xenopus and zebrafish model systems. The training plan involves interdisciplinary training with exposure to both academic and business settings. The trainees will acquire technical expertise in embryonic anatomy and development, genomic profiling, sequence conservation and evolutionary relationships of regulatory elements, genetic and chemical screens, mass spectrometry, informatics, statistics and computational modelling, and will be trained in a range of soft and complementary skills.Therefore the DevCom Training and Research Programmes are designed to foster readiness for leading roles in academia and indus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Flood risk reduction by space borne recognition of indicators of ex cess runoff generating areas' (FLOODGEN) targeting Fourth Framework.

assistant: **Abstract**

Floods are among the major natural hazards affecting landscapes, agriculture and human activity. They cause recurrent losses of yields, of revenue and sometimes of human life. They also contribute to the erosion and destruction of soils, to loss of fertilisers and to the spreading of pollutants. Although hydrological models can help to forecast runoff and flood behaviour, generation of floods, especially the strong ones, is highly dependent on the physical characteristics of the upstream drainage basin. These characteristics are usually govemed by physiography, permeability, crusting and saturation of soils and surface materials, as well as by vegetation cover and human intervention on the landscape such as agricultural practices and urbanisation. Several regional authorities as the Regional Council of the Upper Normandy Region or ERSAL, the regional board for agricultural development in Lombardia have adopted similar strategy for the regional management of excess surface-water runoff, with the aim of reducing its consequences. This strategy involves the regional actors and, among them, those representing the Ministry of Agriculture, whose mission is to bring into play agricultural policies on the regional level and to see that there is a greater consideration of agro-environmental components in policy making. The main objectives of this strategy is to restrict or control the risks associated with surface runoff, erosion and deterioration of the quality of agricultural waters that supply aquifers and to work towards the joint management of catchment basins. A regional approach is one of the prerequisites for concerted actions at various scale of investigation, from individual plots, through catchment basins, to an entire agricultural unit and an administrative region. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Computational Complexity of Highly Nonlinear Approximations'.

assistant: **Concept**

The efficient numerical treatment of partial differential equations on high-dimensional spaces often requires approximation methods involving a high degree of nonlinearity, such as low-rank tensor representations or neural networks. By exploiting structural features of solutions, such approaches in many cases promise extremely efficient approximations. However, due to the corresponding greater difficulty of computing highly compressed representations, such results need to be considered in conjunction with the costs of numerical methods for constructing these approximations. A main objective of the project is to address the gap between theoretical complexity bounds and the performance of practical implementations of solvers, with particular focus on low-rank tensor representations, linear combinations of arbitrary Gaussian functions, as well as neural networks and more general compositions of functions. We also aim to understand the relative suitability of particular nonlinear approximation methods for different problem classes, such as problems with many parameters, evolution problems for probability distributions and wave functions, and eigenvalue problems in quantum chemistry. In each case, it is crucial to avoid numerical instabilities in the interaction of nonlinear approximations and differential operators and to ensure reliability of results in high dimensions by suitable computable error bounds.


**Keywords:** Numerical methods for partial differential equations, high-dimensional problems, parameter-dependent problems, evolution problems, eigenvalue problems, nonlinear approximation, adaptive methods, complexity estimates, sparse expansions, low-rank tensor representations, linear combinations of Gaussian functions, neural networks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Satisfiability and group rings' in the context of a Horizon Europe call.

assistant: **Objectives**

Group rings are key objects in many fields of mathematics including algebra, topology, operator algebras and representation theory. Fundamental questions about them remain unanswered, in particular several conjectures attributed to Kaplansky. For torsion-free groups and field coefficients, the zero divisor conjecture predicts the absence of zero divisors and the idempotent conjecture predicts that 0 and 1 are the only idempotents in the group ring. The direct finiteness conjecture says that left-invertible elements are invertible in group rings of arbitrary groups over fields. These conjectures have a history spanning more than 80 years. Although special cases are known, resolving any of the conjectures in full generality seemed intractable until the recent disproof of the closely related unit conjecture.The goal of this project is to construct counterexamples to the zero divisor and direct finiteness conjectures. The latter will give the first example of a non-sofic group. We also seek to resolve the unit conjecture in characteristic zero. Key to our approach is the application of modern solvers for Boolean satisfiability. This paradigm shift, which was successful against the unit conjecture, shows that these problems are substantially more vulnerable to computational techniques than previously thought. Constructing our counterexamples will require both developing our understanding of candidate groups and their properties and building a toolkit for the effective application of existing computational machinery. The unique product property obstructs the existence of counterexamples to these conjectures and is thus of great interest. We will answer fundamental questions about this property.Although we focus on the positive characteristic case, this project will lay seriou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Adaptive Laser Beam for additive manufacturing'.

assistant: **Objectives**

The ALABAMA project aims to develop and mature adaptive laser technologies for AM. The objective is to lower decrease the porosity and to tailor the microstructure of the deposited material by shaping the laser beam, both temporally and spatially, during the AM process. The key innovations in the project are to develop multiscale physics-based models to enable optimization of the AM process. These process parameters will be tested and matured for multi-beam control, laser beam shaping optics and high-speed scanning. To ensure the quality of the process, advanced online process monitoring and closed loop control will be performed using multi spectral imaging and thermography to control the melt pool behavior coupled with wire-current and high-speed imaging to control the process. To verify that the built material fulfills the requirements, advanced characterization will be conducted on coupons and on use-cases. The matured technology will be tested on three use-cases; aviation, maritime and automotive. These three industrial sectors span a broad part of the manufacturing volumes: from low numbers with high added value, to high numbers with relatively low cost. However, all these sectors struggle with distortions, stresses and material quality. The ALABAMA use-case demonstrators will improve the compensation for distortions during the AM process, reduce the build failures due to residual stresses, reduce porosity and improve tailoring of the microstructure. Overall, this will contribute to up to 100% increase in process productivity, 50% less defects, 33% cost reduction due to increased productivity and energy savings, a reduction of 15% in greenhouse gases and enable first time-right manufacturing thanks to simulation, process monitoring and adaptive control. The end use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BILIVERDIN REDUCTASE-A IN BRAIN INSULIN SIGNALING AND OXIDATIVE STRESS- MEDIATED NEURODEGENERATION' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Alzheimer disease (AD) is the most common form of dementia among the elderly, whose care in Europe demands an amount of financial resources which is rising dramatically making AD a financial problem. Delaying AD onset by 5 years would decrease its prevalence by 50% with an enormous impact on the financial resources involved in AD care. Hence, it is necessary to understand the mechanisms related to the earlier phases before the symptoms onset. Insulin resistance is associated with a higher risk to develop AD. Post-mortem analysis of brains from AD subjects revealed a markedly downregulated expression of the insulin receptor (IR) and its downstream targets, which progresses with severity of neurodegeneration. Biliverdin reductase-A (BVR-A) is a pleiotropic enzyme that not only catalyzes the synthesis of the powerful antioxidant bilirubin but through its Ser/Thr/Tyr kinase activity modulates cell signaling networks including the two main arms of insulin signaling: MAPK and PI3K. Further, BVR-A is directly activated, via Tyr phosphorylation, by IR. Thus, being BVR-A an up-stream effector in the IR-mediated signaling cascade I hypothesize that the impairment of BVR-A activity contribute substantially to the progression of insulin resistance observed in AD, likely due to the oxidative damage as reported in the brain of aMCI and AD subjects. The aim of this project is to provide evidence about age-associated BVR-A-dependent changes of (i) oxidative/nitrosative stress levels; and (ii) the insulin-induced signaling pathways in 3xTg-AD mice model of AD. Finally, the effect of intranasal insulin (INI) administration, will be evaluated to describe age-dependent insulin effects on IR/BVR-A-dependent signaling pathways and cognition, to rule out if defects in insulin singling are ass