RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targeting RAS driven tumour immune evasion' (RASImmune).

assistant: **Concept**

Mutations in RAS oncogenes are responsible for driving some 20% of all human malignancies, occurring in many major killers, such as lung, pancreatic, and colon cancers, but attempts to develop therapeutic interventions for RAS mutant cancers have yet to provide clinical benefit. By inhibiting pathways downstream of RAS along with other key signaling nodes, we have developed combination therapies that cause major regression of KRAS mutant lung cancer in mouse models. However, a major limitation is that the tumours are not eradicated and rapidly recur once treatment is withdrawn.Lung cancer is partly responsive to immunotherapies in the clinic, suggesting dependence on immune evasive signaling. We would like to understand whether RAS driven oncogenic signaling pathways act to protect tumours from the immune system. If so, what mechanisms does RAS use to evade tumour immune destruction and can these be specifically targeted to unleash the immune system on the tumour? Could we develop effective therapies rationally combining these with our existing RAS pathway therapies to achieve complete tumour eradication?We will use clinical samples to establish whether activation of RAS signaling pathways correlates with the ability of lung tumours to evade the immune system and by what mechanisms. We will develop appropriate preclinical models to test the impact of targeting immune evasion in RAS driven lung cancer, recognising the major limitations of existing mouse models for this purpose. We will also utilize these immunogenic preclinical models to seek novel mechanisms of tumour immune evasion, including through the use of in vivo functional genomic screens. Finally, we will establish how our existing optimal strategies for achieving RAS signaling pathway inhibition in lung cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ultra-trace element fingerprinting of geological and environmental archives', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Natural and anthropogenic processes leave behind tell-tale chemical signatures - fingerprints - that inform researchers about a wide variety of interesting and topical issues. The research proposed here aims at refining our ability to read the chemical fingerprints both in geological and environmental archives. The research will have a strong technological component and a number of applied projects in which chemical fingerprinting will be used and with which students will be trained.In a first stage, an ultra trace element facility will be established at Trinity College Dublin, Ireland. This will consist of ultra-clean space, ultra-clean sample preparation facilities and a mass spectrometer. It will also include fabrication of customised sample introduction systems to lower the limits of detection. Once established, after a period of 1.5 years, phase 2 of the programme will use chemical fingerprinting to i) detect ancient volcanic ash deposition events in British and Alpine peat bogs; ii) attempt to shed light on the evolution of the first multi-cellular life forms preserved in c. 700 million year old sedimentary rocks, and iii) help to reconstruct climate change signals from dust deposited in polar ice cores.In the late 1990s and early 2000s, Australian researchers started the science of chemical fingerprinting. The applicant was part of this development and has since further refined the techniques in Canada. This proposal aims to help establishing a world-leading research group in the E.U. by means of supplementing investment into equipment, consumables, support of graduate students and field work. The research is in an area of designated growth and strength at the host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'SWIPT- MED: Simultaneous Wireless Information and Power Transfer for Medical Implants'.

assistant: **Objectives**

The growth and extensible research in active implantable medical devices (AIMDs) have provided the opportunity for continuous and remote monitoring of patients with chronic illness. But the major technological challenge is that most of the implants operate on batteries with limited durability. It is difficult to replace these implants as human tissues grow around them and requires surgeries for their removal, which are costly and stressful for the patients. Moreover, battery replacement surgeries require hospital stays which is an additional risk in this era of pandemics like COVID-19. So, the sustainability and eventual fate of implantable medical devices depends on its capability for long-term use.Most of the AIMDs are equipped with wireless communication systems for data transfer, device monitoring and reprogramming. In this regard, I propose that energy harvesting from radio frequency (RF) signals for a wireless communication system provides a new paradigm called Simultaneous Wireless Information and Power Transmission (SWIPT) that can allow the wireless implant nodes to recharge their batteries from the RF data signals.In the literature, SWIPT has been studied for in-door and outdoor environment and has investigated transmission of high energy levels with large antenna dimensions for harvesting energy. There have been no studies in the literature for investigating SWIPT within the human body. My research project will explore and untap the potential of SWIPT for the human body environment. The major outcomes of the project include: 1) optimum energy-capacity function and the end-to-end analytical model of SWIPT for deep implants; 2) hardware design of SWIPT for implant communication systems; and 3) feasibility of the novel SWIPT architecture for medical implant tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chiral Flame Retardant Materials: Design, Synthesis and Study of Chirality-Flame Retardancy Relationship between the (R)-Enantiomer and (S)-Enantiomer' (REMES).

assistant: **Concept**

The development of new strategy to study flame retardant polymers is an exceptionally important area of current research in Material Science and Engineering field since the fire safety of materials is extremely important to the whole society. So far, very seldom study focuses on the chiral flame retardant materials, especially almost no systematic study on exploring the different flame retardancy between (R)-enantiomer and (S)-enantiomer of chiral flame retardant materials. The main objective of this innovative work is to use optically pure chiral compounds to develop new generation flame retardant polymer nanocomposites by combining (R)- or (S)-enantiomer of chiral flame retardant materials into polymeric matrices. In this work, optically pure chiral compounds are employed to develop flame retardant polymer nanocomposites for the first time. The eco-friendly, economical, easily prepared and functionalized chiral BINOL phosphates are chosen as the chiral flame retardant. By introducing functional groups into the BINOL phosphates, it can be combined with polymeric matrices via chemical interaction to construct polymer nanocomposites. Moreover, incorporating ferrocene unit as synergistic agent into the BINOL phosphates, the resulting multifunctional flame retardants to polymer nanocomposites will have advantages including mechanical reinforcement, enhanced thermal stability and excellent flame retardancy and smoke suppression properties, simultaneously. More significantly, chirality-flame retardancy relationship between the (R)-enantiomer and (S)-enantiomer of chiral BINOL phosphates would be systematically investigated to understand the flame retardant mechanisms in a new aspect. The new knowledge and new materials developed in this proposal has the promise to be applied
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Collaborative Software Development Framework based on Trusted, Secure Cloud-based Pool of Users'.

assistant: **Innovation**

CloudTeams will be a cloud-based platform transforming software development for cloud services into a much easier, faster and targeted process, by engaging communities of users who will participate in the product life cycle to help software teams develop better solutions for customers’ problems.Main challenges addressed by CloudTeams are first, the fragmented European market that makes adaptation of innovations difficult and expenses for market research extremely high and second, the lack of tools and incentives for users to collaborate with talented software teams around Europe towards developing better solutions. CloudTeams will solve these problems, by bringing end-users into its platform, use existing data to find the proper match with a project, and facilitate the communication between the software team and the users throughout the whole development process. CloudTeams will use endpoints to existing services and tools that are popular in software development, by mashing them up with common practices. It will support developers with a collaborative platform where interaction with customers will feel natural and will validate the final outcome. CloudTeams is the intersection of three important fields: crowdsourcing platforms, collaborative software development tools and trusted cloud services delivery. This innovative combination of different tools and practices under a unique concept will be enhanced with a rewarding system to enable end-users to jump into the platform and support solutions they are interested in. In addition a testing and trust framework will validate the whole process based on proper analytics and qualitative feedback by the prospective customers. The final cloud-based solutions will be validated based on the CloudTeams methodology and thus truste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LEDiR: A Ground-breaking Manufacturing Process to Yield a Unique Prosthesis for Lumbar Endoscopic Disc Replacement', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Today our society faces a major challenge coming from the progressive ageing of the population & the rising incidence of chronic diseases. Indeed, the healthcare system is desperately seeking for new ways to address the many conditions arising due to the natural ageing process. One of these conditions is the group of degenerative disc diseases, which entails a deterioration of the vertebral discs responsible for the flexibility & cushioning of our spine. This condition affects around 40% of the population aged 40, increasing up to 80% when aged 60. Although there is some room for management if diagnosed early, most patients need to undergo surgery for replacement by either fixing the vertebrae or introducing a prosthesis. However, both the materials used for the replacements and the surgical procedures have important shortcomings in terms of safety, risks, costs, biocompatibility and spine recovery. Thus, there is a clear need to find an alternative that is less invasive and more cost-effective to the healthcare system. In response, the consortium made by Additiva & Tsunami aims to bring to market LEDiR, an innovative prosthesis for lumbar disc replacement whose fully articulated structure enables implantation through a non-invasive endoscopic approach. While a ground-breaking process of laser sinterization confers LEDiR a unique form that mimics the shape of the spine, a core of biocompatible silicon brings its flexibility. After proving the safety & reliability of the production process and the prosthesis, we now want to finalise its development and prepare LEDiR for the market stage. The Feasibility Study planned for Phase 1 aims to warrant our project from all technical, financial & commercial points of view. Upon completion of this project, we will be able to bring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Monitoring care and treatment of cancer patients in clinical practice by the use of QoL assessments' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Many Quality of Life (QoL) instruments have questionable validity since they capture health status rather than QoL as perceived by the individual. For most QoL instruments experts have generated items and equal weightings of different QoL domains are assum ed. This is contradicted by research showing QoL as highly individual. An alternative approach is to use Individualised Quality of Life (IQoL) instruments that capture QoL as defined by the individual.This proposal focuses on IQoL in cancer and on the use of IQoL to optimise clinical care. An acknowledgement of the unique nature of QoL for the individual is arguably nowhere more important than in life-challenging situations such as serious illness. Monitoring cancer patients with IQoL instruments in clinica l practice might be a way to individualise care, enhance patient-physician communication with regard to psychosocial concerns and improve patient outcomes, primarily QoL. The overall aims are to:-evaluate the efficacy of IQoL instruments as a means of indi vidualising cancer care-identify the most appropriate instrument for this purpose. A cancer-specific instrument (EORTC-QLQ-C30) and an individualised instrument (Schedule for Evaluation of Individual Quality of Life ¿ Direct Weighting (SEIQoL-DW)) will be compared-explore the experiences of, and attitudes to, QoL assessments in clinical practice among patients and health care personnel -identify the minimal clinically important differences (MIDs) for EORTC-QLQ-C30 and SEIQoL-DWThis project will inform decis ion makers and health care personnel about the use of QoL instruments for care planning and individualisation of treatment. Many interventions fail to be implemented in clinical practice, even when proven effective. Results from this study will be used to opti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Expanding the Research and Innovation Capacity in Cultural Heritage Virtual Reality Applications'.

assistant: **Innovation**

Cultural heritage has always been an effervescent subject among historians, sociologists, naturalists, scientists and researchers alike. The physical and intangible legacy of previous generations is passed via this channel to future members of the society. It is a deliberate act, as conserving the results of past work, culture and even biodiversity is in the very nature of the human beings. With the recent advancements in the field of virtual reality, intelligent systems and based on the emergence of the information society, we can now ascend to modern cultural heritage preservation techniques. eHERITAGE has as main objective the development of a center of excellence in virtual heritage.The coordinator of this project is not new to the research field which he wishes to expand. The Virtual Reality and Robotics Department (VRRD) of the UTBv has an affinity for designing and developing applications of virtual reality for cultural heritage, as it has had involvements in past national research projects on this theme. The partners of eHERITAGE are internationally leading entities in the focused research field. SSSA is a public university located in Pisa, Italy. Its mission is not only didactic, as SSSA excels in several research areas, including robotics, virtual reality and user interfaces. The historic background of SSSA’s location eased the development of the virtual reality applications in cultural heritage. Several international research projects and well as a wide publication profile come to sustain this statement. On the other hand, JSI is the most important research institute in Slovenia, ranked among the first 50 research centers in Europe. In particular, JSI has strong competences in building models for ambient intelligence applications, data farming and detailing h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mainstreaming gender dimensions into water resources development and management in the Mediterranean region' (GEWAMED) under Sixth Framework.

assistant: **Objectives**

The project plans to build an extensive knowledge base for mainstreaming gender dimensions into IWRM. To achieve this objective the project will build a regional network and establish 6 national ones using Internet technology in, at least 6, countries of t he South East Mediterranean Region(SEMR). The regional network will be essentially a mean for exchanging experiences, disseminate results and allow for enhanced coordination among national projects' activities and participants.The project will improve the cooperation and dialogue among partners and external organizations interested in this subject through the participation in 3 regional workshops and an International Conference that will be held at the end of project life. The project will interact with ot her MPC projects, like MELIA, INECO and WADI, that also focus on information, knowledge management to promote coordination and exchange of experiences. It is also expected that the project will contribute to improve the coordination of gender activities in an IWRM context and to disseminate information, particularly in the rural areas. For this purpose GEWAMED will establish a National Central Focal Points in each SEMR country that will interact with the other collaborating institutions involved in the wat er sector. This will be not only a coordination mechanism but also an important mean to collect and disseminate gender information spread among many institutions. One of the most distinctive feature of GEWAMED is precisely the establishment of a knowledge base for acquiring and disseminating gender information at national level. The project may also contribute to the adoption of national policies and other related instruments (strategies,approaches, guidelines, incentives and legislation) by involving decis ion ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structure-Property Relations in Aqueous Foam and Their Control on a Molecular Level' (SUPERFOAM).

assistant: **Innovation**

Foams are of enormous importance as we find them in many technological relevant applications and food products. Foams as hierarchical materials are dominated by the arrangement and distri-bution of gas bubbles on a macroscopic scale, as well as by thickness and composition of lamella on a mesoscopic scale. Liquid-gas interfaces are, however, the building block of foam with over-whelming importance as their molecular properties easily dominate hierarchical elements on larger length scales. In order to formulate foam with specific properties, its structure must be controlled at the molecular level of a liquid-gas interface. Here, the molecular composition, molecular order and interactions such as electrostatics dominate, and thus must be addressed with molecular level probes that can provide access to both interfacial solvent and solute molecules. Specifically, mo-lecular structures of aqueous interfaces can be modified by adding different mixtures of surface active molecules such as proteins, surfactants and polyelectrolytes, and by adjusting electrolyte properties. This is achieved by varying pH, introducing ions at different ionic strengths as well as by changing viscosities. Such model systems will be characterized with nonlinear optical spectroscopy amongst other surface sensitive probes. The gained information will be used to deduce properties of structures on larger length scales such as lamella, bubbles in a bulk liquid - as a precursor of foam - and finally macroscopic foam. For each length scale, experiments will be performed to gain access to molecular buildings blocks at liquid-gas interfaces and their effects on other hierarchical elements. These experiments thus provide essential information on foam stability and bubble coalescence, they can be used to verif