RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Support action: pilot initiative for european regional repositories' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Some small nuclear power programmes in the expanded EU may not have the resources or the full range of expertise to build their own geological repositories. Even for countries that could potentially implement national projects, there are environmental and economic advantages in co-operation. The prospect that countries could work together to explore regional solutions is raised in the EC radioactive waste Directive. Such solutions raise new trans-national issues of safety and governance, nuclear security, n ational & European public acceptability, trans-boundary transport and national & European economics and law. SAPIERR is a pilot initiative to help the EC to begin to establish the boundaries of the issue, collating and integrating information in su fficient depth to allow potential regional options to be identified and the new RTD needs to be scoped. Possible future programme components and structures will be suggested. The work will: - develop a collaboration framework and a comprehensive database f or regional waste management in the EU - identify amounts, types & times of arising of relevant wastes, including spent sealed sources - identify possible concepts for European regional storage & disposal - identify the main safety & governance implications raised by these concepts - examine whether there are new, trans-national RTD requirements - develop strategy options to explore the concept/options further - propose mechanisms for developing strategy options & RTD needs in future EU prog rammes. The work will involve a working group of interested countries and will be reported also at an international seminar and to the EC. A commitment to participate in the working group has already been signalled by organisations from some EU Member Stat es and from numerous Candid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Support in order to strengthen the capacities of the water analysis laboratory, Beirut water board (OEB)'.

assistant: **Innovation**

Water quality monitoring is disorganised within the Beirut Water Board (OEB). Public health is threatened, particularly in Beirut. The aim is to allow the Water Analysis Laboratory of the OEB to monitor resources and carry out surveillance of the quality of water that is distributed.In the short term, the Greater Lyon Water Department in France and the Moroccan National Drinking Water Office (ONEP) will coordinate their efforts to define the procedures, management and training required for the operation of this laboratory, to strengthen its capacities and support its renovation. Within an international professional network, and with this support, the OEB laboratory should be able, in the mid-term, to recover the efficiency which is essential to public health and the sustainability of resources in Beirut.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The physics of antibiotic resistance evolution in spatially-structured multicellular assemblies' (EvoStruc) under Horizon 2020.

assistant: **Objectives**

The rise in bacterial infections that are resistant to antibiotic treatment poses a major global health challenge. Addressing this challenge is not just a clinical issue: understanding bacterial resistance evolution calls for an interdisciplinary approach, in which the development of new physics, in coordination with biology, chemistry and engineering, has a central role to play. In particular, statistical physics, to predict the stochastic emergence of drug-resistant mutants, must be integrated with soft matter and chemical physics, to understand the spatial organization of the bacterial populations within which this happens.Bacterial infections are very often spatially heterogeneous. This is known to influence the outcome of antibiotic treatment – for example bacterial biofilms, which form on the surfaces of medical implants, are notoriously hard to remove. However, much less attention has been paid to the role of spatial structure in the evolution of drug resistance, i.e. the emergence and spread of genetically drug-resistant bacterial strains. I will lead a research programme which will for the first time uncover the two-way link between the emergence of spatial structure in bacterial multicellular assemblies and the evolution of drug resistance. The programme builds on my current theoretical, simulation and experimental work. I will first determine the basic principles of evolution in drug gradients using theoretical models, combined with experiments in a controlled, 1D geometry. I will then explore how these principles translate to the more realistic scenario of bacterial biofilms, where spatial structure and drug gradients are emergent properties, using advanced computer simulation methods and both confocal microscopy and evolution experiments. In the final part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'RELIABILITY AND SAFETY ENHANCED ELECTRICAL ACTUATION SYSTEM ARCHITECTURES' (RESEARCH), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of RESEARCH project is the definition of an electrical architecture for Flight Control System capable of controlling a flight control surface on an Aircraft with the help of electrically operated actuators, thus replacing the hydraulic actuators commonly used in current Aircraft designs.This architecture will be designed with the main objective of being electrical, as this is the main purpose of this call, and certifiable, since the intention is to be able to use it in a possible future Aircraft.The objective of the RESEARCH project is to find a robust architecture to meet the constraints imposed by safety regulations while keeping other system performances (as weight, Reliability) as optimal as possible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'artificial Intelligence threat Reporting and Incident response System'.

assistant: **Concept**

Uptake of IoT and AI driven ICT systems in Europe is crucial for our common future, but it is dependent on our strategic ability to protect these systems from cyber threats and attacks on their privacy. IRIS addresses this challenge with a collaborative-first approach centered around CERTs/CSIRTs. From a technological perspective, it deploys (i) autonomous detection of IoT and AI threats, enriched with (ii) privacy-aware intelligence sharing and collaboration, and (iii) advanced data protection and accountability. Crucially, IRIS introduces (iv) the first dedicated online training and cyber exercises to prepare CERTs/CSIRTs to collaboratively protect critical infrastructures and systems against cross-border AI and IoT threats. IRIS will be validated in three pilot demonstrators, focussing in the IoT, AI and cross-border dimensions, across three existing smart city environments (in Helsinki, Tallinn and Barcelona), involving the associated national/governmental CERTs/CSIRTs, cybersecurity authorities and municipalities. The scenarios will contain real-life inspired cyber incidents that will build up into pilots at all levels (from local to national and to cross-border) to showcase the versatility of the IRIS solution. With 19 key partners from around Europe and 5 CERTs/CSIRTs as Associated Partners, IRIS’s solid consortium composition and work plan prioritises the effectiveness needed for quick real-world adoption and impact. Moreover, integration will be carried out on the EU’s existing MeliCERTes platform, with the support of NETCOMPANY-INTRASOFT, while training will build upon THALES’s existing cyber range, and ECSO will ensure the contribution to standards and policymaking. With the formal support of the four H2020 Cybersecurity Competence Network Pilot Projects, IRI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Theoretical and Algorithmic Foundations for Future Proof Information and Inference Systems'.

assistant: **Objectives**

A critical technological challenge for emerging information systems is to acquire, analyze and learn from the ever-increasing high-dimensional data produced by natural and man-made phenomena. Sampling, streaming, and recoding of even the most basic applications now produce a data deluge that severely stresses the available analog-to-digital converter, digital communication and storage resources, and easily swamps the back-end processing and learning systems.Surprisingly, while the ambient data dimension is large in many problems, the relevant information therein typically resides in a much lower dimensional space. Viewed combinatorially and geometrically, natural constraints often cause data to cluster along low-dimensional structures, such as unions-of-subspaces or manifolds, having a few degrees of freedom relative to their size. This powerful notion suggests the potential for developing highly efficient methods for processing and learning by capturing and exploiting the inherent model, or data’s “information level.”To this end, we seek to revolutionize scientific and practical modi operandi of data acquisition and learning by developing a new optimization and analysis framework based on the nascent low-dimensional models with broad applications—from inverse problems to analog-to-information conversion, and from automated representation learning to statistical regression. We attack the curse of dimensionality in specific ways, not only by relying on the blessing of dimensionality via concentration-of-measures, but also by exploiting geometric topologies and the diminishing returns (i.e.,  submodularity) within learning objectives. We believe only an approach such as ours can provide the theoretical scaffold for a future proof processing and learning framework that sca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling of the impact on ozone and other chemical compounds in the atmosphere from airplane emissions', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The lower stratosphere/upper troposphere are areas of importance for ozone depletion, climate and interaction between chemistry and climate through ozone. Our knowledge of how chemical processes in general, and aircraft emissions in particular, affect the distribution of ozone and other key compounds in these regions is limited. However, with the projected large increase in future aircraft operations and thus emissions, studies of future impact on lower stratospheric/upper tropospheric chemical composition is needed. In order to address these scientific issues the overall objective for the AEROCHEM proposal is the impact of past, present and future emissions from both subsonic and supersonic aircrafts on upper tropospheric and lower stratospheric ozone. The project will contribute to a better scientific knowledge of the processes controlling ozone in height regions where ozone change could contribute significantly to climate change.The basic tool in this study will be 3-D CTMs (Chemical Transport Models) which have been developed by the  participating groups, and where the emphasis is on processes affecting transport and chemistry in the lower  stratosphere and upper troposphere. The models will have different formulation of chemistry and transport, and  represent state of the art 3-D modelling. As a supplement to the 3-D studies 2-D CTMs with detailed gas phase  chemistry will be used to investigate long term effects of aircraft emissions.  In order to improve our understanding of the key processes identified above in the ozone chemistry, and to  perform realistic 3-D estimates of the past, present and future impact on ozone from airplane emissions, a set  of tasks is selected as necessary parts of the work plan. The tasks of the work plan are outlined below.  Task 1.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Conversion of integral membrane receptors into soluble forms' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

G-protein coupled receptors (GPCRs) are cell surface receptors that mediate the cellular responses to an enormous diversity of endogenous signaling molecules as well as environmental signals. GPCRs are a major target for the pharmaceutical industry as is reflected by the fact that more than 50% of all medicines available today act on a GPCR and represent about a quarter of the top-selling drugs worldwide. However, effective drug design and functional characterization of these receptors is strongly limited by the absence of high-resolution structural information because of the many practical problems of working with membrane proteins. Here, we propose to replace the lipid-exposed hydrophobic residues within the transmembrane domains of GPCRs with more hydrophilic residues to engineer water-soluble variants of GPCRs capable of folding in aqueous solutions. Moreover, detailed comparison of membrane proteins and soluble proteins by protein engineering will also lead to a deeper insight into membrane protein folding and stability with important consequences for the handling of drug targets. Redesigning a GPCR by substituting the hydrophobic amino acids of the protein/lipid interface with suitable polar or charged residues to produce a molecule that is able to fold and function in aqueous solution represents an ambitious protein-engineering problem of high combinatorial complexity. It is improbable that we will reach the desired result in a single step by rational design. Instead, we have chosen a highly interdisciplinary approach that combines the strengths of computational and experimental tools, of design, selection and in vitro evolution. The strategy, we propose to use, relies on the proven expertise of the Plückthun group in the rational design of protein libraries. Fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel and more robust fungal peroxidases as industrial biocatalysts' to be submitted under Seventh Framework.

assistant: **Abstract**

Enzymes catalyzing redox reactions (oxidoreductases) represent an environmentally-friendly alternative to harsh chemical reagents in industrial processes that include oxidative transformations for the production of chemicals and other value-added products with large markets in developed and emerging economies. Fungi and other micro-organisms provide the wider and more easily exploitable source for this type of enzymes. However, the penetration of microbial oxidoreductases in the above markets is still low despite the recent discovery of some of the most promising enzymes. Moreover, the use of enzymes as biocatalysts requires tuning their catalytic and operational properties, a type of genetic manipulation that is possible nowadays by the use of protein engineering tools. In the above scenario, the PEROXICATS project focuses first on the search for new peroxidases, one of the most interesting types of oxidoreductases due to their high redox-potential and unique peroxygenase activity recently described in some of them. The huge amount of genomic resources available nowadays, and to be generated during the course of the project, will be exploited in the search for new fungal peroxidase/peroxygenase genes. This will provide a collection of new enzymes to be evaluated in different oxidation reactions that could result in interesting products. On the other hand, some of the main issues presently limiting the industrial application of these enzymes will be addressed, namely their suicide inactivation by peroxide, low functional expression, and limited oxygen transfer potential. Moreover, the catalytic properties of the most interesting enzyme candidates will be modulated to adapt them to the industrial processes. In both cases, a combination of rational and non-rational design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Artificial Molecular Machines'.

assistant: **Innovation**

Artificial molecular machines have the potential to revolutionise medical treatment, material design, and energy conversion for the benefit of the European and global community. Key fundamental aspects have been studied and the findings were awarded with the 2016 Nobel Prize for Chemistry. Now it is time to guide the research further towards game-changing implementations that utilise artificial movement of molecules and orchestrate them in large systems. Therefore, we propose the ITN project ArtMoMa, which aims a) to push the current scientific boundaries further and to explore entirely new directions of fundamental research towards technologically relevant implementations; and b) to educate and mentor 15 curious and highly capable ESRs to form a critical mass of fully skilled young professionals acting as multipliers to develop technologies across Europe. The network is built on synergies and complementarities between leading scientists (with for instance the involvement of 4 Nobel Prize Laureates), world-class institutions, different disciplines, and the incorporation of several industries as drivers – ranging from start-ups to SMEs to global players – from all over Europe. In the medium- to long-term, we have the joint vision to create new and sustainable education structures with strong involvement from key stakeholders and including industry. This will build a continuous stream of leading European scientists who will create further knowledge and innovations in the future, ranging from processes to products to services and resulting in economic growth and leadership in this field.


**Keywords:** Molecular motors, Nanomachines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Action for advanced Drivers assistance and Vehicule control system implementation, Standardisation, Optimum use of the Road network and Safety'.

assistant: **Concept**

Research and development have created a range of advanced driver assistance systems (ADAS) that may facilitate the tasks of drivers in the growing complexity of traffic conditions. Appropriate ADAS will be selected from a problem focussed angle and analysed in a multidisciplinary approach, in order to gain new policy insights. All the stages for a potential breakthrough of ADAS will be investigated: the market conditions, the impacts on driving behaviour, road safety and environment, role of the public regulator, public acceptance, implementation strategies etc. Assessment methodologies will be developed and applied in order to deliver empirical evidence. This evidence together with questionnaire surveys will fit into a developed division scheme. This approach leads to an integrated framework suited for designing road safety policies to help realise suitable ADAS. Policy recommendations and guidelines are put forward in the last stage.