RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The price of success: what is the impact of improving patients’ survival on utilisation of care?' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Unplanned emergency admissions absorb a large share of the resources allocated to the Health System and are growing at a fast rate in many European countries. The drivers of this growth go beyond demographic factors and have not been properly investigated until recently due to the lack of rich longitudinal datasets following a large population of patients for many years and a gap in the transfer of knowledge between Economics and Public Health disciplines. My ambition is to fill this gap in the knowledge by applying state-of-the-art econometric models to an exceptionally comprehensive and longitudinal dataset on the population of Danish patients, thus offering a unique opportunity to inform new policies on the appropriate tools to manage the growing demand for emergency care and the financial sustainability of the Health System, and policies aiming at reducing hospital readmissions. Access to new data, knowledge and training at the Danish Centre for Health Economics in SDU will allow me to greatly advance and expand my stream of research and will have a remarkable impact on my career development. The proposed research will address the following questions:1. What is the long-term impact of improving patients' survival on subsequent use and costs of care?2. To what extent can primary care reduce the use of secondary care following “the survival effect”?3. To what extent can higher integration of care between acute and post-acute services reduce the use of secondary care following the survival effect?4. Is the impact of the survival effect different according to patient’s socioeconomic characteristics? I will identify the profile of patients who are more likely to use care after surviving an acute event, and those who are more likely to benefit from primary care and integr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Direct methanol fuel cell : system development and a stack construction' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives The Direct Methanol Fuel Cell (DMFC) is an electrochemical power source based on a simple principle but which is difficult to realise as a commercial power generator. The objectives of the project are the evaluation of a multi-celled direct methanol fuel cell system and a subsequent development of a fuel cell in the kW power range. Further, the aim is to develop a process which would render a uniform and reproducible manufacturing process of large membrane/electrode units possible. Cost reduction and economical performance of the stack will also be a key point. Technical Approach In pursuing the goal, the combined effort on the development of catalysts, membrane/electrode units and system/stacks will concentrate on seeking new constructional and functional materials, especially catalysts for the anode and cathode with low loadings of noble metals and optimised membrane/electrode assemblies. This will be achieved by the development of specifically tailored types of carbon supported Pt/Ru base anode catalysts for increased activity for the methanol electro-oxidation, and cathode catalysts for oxygen reduction which are more tolerant to the presence of methanol arising from permeation through the membrane electrolyte. These aspects in turn will serve to optimise the membrane/electrode units by taking into account the electrode structure and the catalyst utilisation, and ultimately to scale-up of assembly fabrication. The process management would depend on the nature of operation and the resulting cell reactions. So a multi-celled battery will be constructed and put on trial under different operational conditions to verify the performance, process control and regulation. The trial will also lead to the choice of suitable constructional materials. Based on the exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The geometry of temporal cognitive maps  CHRONOLOGY' under Horizon Europe.

assistant: **Concept**

Experiencing the world and inferring its causal structure rely on the flexible temporal organization of information in the brain, enabling future planning in thoughts and actions. Understanding how the brain maps events in time is essential, yet surprisingly little is known about the neural mechanisms by which the brain represents time and uses it for computations. Based on the observation that complex neural activity accompanies the mental evaluation of time across species, our project aims at testing the hypothesis that the collective dynamics of brain circuits involved in memory generate and organize representation of temporality. To identify the key structures of time representations in the brain, we will record neural activity at different neuroanatomical scales (from neuron to whole-brain) in three species (rodents, non-human primates, and humans) while individuals are behaving in timing tasks of varying cognitive complexity. A geometrical analysis of neural activity will determine the existence of temporal cognitive maps that provide individuals with a mental chronology of experienced events. We will test if the navigation of temporal cognitive maps is involved in tasks where individuals mentally travel in time. Exploiting state-of-the-art artificial intelligence methods to build interpretable recurrent neural network models, we will identify generic processes supporting the emergence of time representations by comparing signatures of theoretical mechanisms with brain activity. Targeted causal manipulation at the single cell resolution will help select precise mechanisms among model-based hypotheses, including the role of local and long-range neuronal connectivity in the establishment of circuit dynamics that develop across time scales. Our synergistic cross-disc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterizing gene regulation in single cells through integration of scRNA-seq and scATAC-seq data with generic multi-modal prior information' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The advent of single cell technologies has enabled the characterization of cell types and developmental processes. Observations from different cells allow one to identify underlying patterns at higher resolution than convoluted bulk data, and integration of different omics data can yield a more differentiated picture of mechanistic connections. In this proposal, Gene REgulatory Cell States (GReCS) from multi-modal data, I plan to develop a computational method that combines these aspects to generate insights into gene regulation at the level of single cells.Measurements of chromatin accessibility in single cells are becoming increasingly common. The method I propose to develop combines sc/sn-ATAC- and scRNA-sequencing data to characterize gene regulation. My approach will integrate and use transcriptomics and open chromatin data to filter comprehensive prior information about candidate interactions and predict cell-specific gene regulatory network versions using machine learning, while sparse single cell measurements are imputed using local cell similarities. In this way, rare measurements across cell types and a larger condition space for network inference can be exploited, using the natural potential of chromatin accessibility data as a filter to map interactions into a cell-specific context.A distinguishing feature of the proposed method is the characterization of local gene regulatory states, which allows the observation of continuous changes throughout a cell-cell similarity embedding. This will be useful to examine changes during cell differentiation and along gradients in spatial reconstructions, for example of embryonic development. The developed methods will be made available to the community as a computational toolkit to improve the characterization of gene re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Establishing a thematic network for priority themes a-c and e in russia for gmes strand 2 assessment activities' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

GMES-RUSSIA establishes a first network of key data providers and users between the European component of the GMES Action Plan and Russia. GMES-RUSSIA serves the initial period of the EC's ESD Work Programme C(2001)4307 for Global Monitoring for Environment and Security. The project's activities are adapted to the Thematic Network approach and the proposed assessment structures: technical-scientific assessment, socio-economic aspects and institutional/organisational/policy issues. GMES-RUSSIA integrates the important Russian data capacities to GMES and strengthens cooperation with Europe. Special emphasis is on the GMES thematic requirements: A-Land Cover Change, B-Environmental Stress, C-Global Vegetation Monitoring and E-Global Atmosphere Monitoring.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Role of Angiogenic Factors in Neurodevelopment' (2007-2013).

assistant: **Innovation**

Despite their distinct functions, the nervous and vascular systems share many more similarities and common principles than previously anticipated2. For example, factors involved in the development of the nervous system are also known to regulate blood vessel formation3. Conversely, the key angiogenic factor, vascular endothelial growth factor (VEGF-A, termed from hereon VEGF), as well as other members of its family such as VEGF-C and VEGF-D, and their receptors, are expressed in neuronal cells and participate in processes such as neurogenesis, neuronal migration, axon guidance, dendritogenesis and dendrite maintenance4-10. All these new findings bring up the new concept of an existing Neurovascular link controlling vascular and neurodevelopmental processes.Despite these initial findings, still little is known about the biology of VEGF or of any other angiogenic factors in neurons, the signaling pathways that they activate and their functional role in neurodevelopment. Thus, this proposal aims to further investigate the role of angiogenic factors and their molecular signaling in neurodevelopment.Determining how angiogenic molecules influence neuronal wiring, will shed new light in the understanding of the molecular control of neuronal development and the possible causes of neurodevelopmental disorders. Research in this field may suggest new strategies to treat those disorders and to promote axon regeneration after injury or disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Durable goods and non-convexities' under Fourth Framework.

assistant: **Concept**

Research objectives and content:Interaction between non durable and durable goods dynamics, with non-constant prices and aggregation when the representative agent's model fails. Estimation of a discrete Markov decision process that is viewed to be suitable for describing the durable goods purchasing behaviour.Training content (objective, benefit and expected impact) I expect to reach a deeper knowledge in the micro-econometrics.Links with industry / industrial relevance (22)Cars are the durable goods that I intend to concentrate on.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cooperation between the aquaculture and agriculture sectors with the intent to use animal manure and fish faeces for sustainable production and utilization of renewable energy and recovered nutrients' (BIFFIO) under Seventh Framework.

assistant: **Objectives**

The BiFFiO project addresses the challenge which both the aquaculture and agriculture industries faces in respects to regulatory requirements and societal requirements for the waste produced, an issue which is in need of sustainable solutions. The concept of the BiFFiO project is to mix the waste readily available from fish farms and manure waste from the agriculture industry in a reactor for production of biogas, which in turn can be used to fill the need for renewable energy in the aquaculture industry and supply fertilizer products to the agriculture industry. The BiFFiO project partners see great opportunities for business development in production of renewable energy from mixed agriculture and aquaculture waste. The main BiFFiO project objectives are 1) Development of a new best practice and novel technology for handling mixed waste from aquaculture and agriculture for production of energy, and further use of the digested waste, 2) Development from current large scale state-of-the art technologies for treating animal waste, to an economical, efficient and scalable three-stage system of pre-treatment, biogas reactor and fertilizer recuperation, which can be located at or in the vicinity of most near shore and on-shore fish farm operations, 3) Application of new technology in the agriculture industry alone or together with fish farming industry, on both remote and central locations to save costs for waste transport and deposition, 4) Impact on socio-economic conditions through the benefits of improved hygienic and environmental standards of closed fish farming and by reduced greenhouse gas emissions and other pollution burdens from the agriculture sector. Five SME AGs and seven Other SME and end user partners from the agriculture, aquaculture and bio-energy sector wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Targeted Brain Delivery of Nrf-2 Gene and α-Synuclein Binding Peptide using Functionalised Gold Nanoparticles for Disease-modifying Therapy of Parkinson’s Disease' under Seventh Framework.

assistant: **Concept**

Parkinson’s disease (PD) is a chronic and debilitating neurodegenerative movement disorder that is set to rise in incidence with a rapidly ageing global population. As current clinical treatments offer only symptomatic control with no curative options, there is an urgent need for novel therapeutic approaches that can delay further neurodegeneration and enhance the overall quality of life in PD patients. Recent emerging evidence on the prion-like spreading neuronal accumulation of misfolded α-synuclein proteins as well as the oxidative stress induced demise of dopaminergic neurons have revealed promising molecular targets for potential disease modifying therapies. Capitalising on the facile synthesis, low cytotoxicities and unique optical properties of gold nanoparticles (AuNPs), we propose the development of two types of novel AuNPs bearing leptin-receptor targeting peptides, namely (a) leptin-poly(ethylene glycol)(PEG)-poly(ethyleneimine)(PEI)-AuNP and (b) α-synuclein inhibitor-/leptin-PEG-AuNP for the respective delivery of the Nrf-2 antioxidant gene (pNrf-2) and α-synuclein peptide inhibitor across the blood brain barrier (BBB). In this study, detailed physicochemical characterisation as well as the evaluation of the cytotoxic and inflammatory properties of the functionalised AuNPs will be studied in a panel of brain-relevant cell types. The BBB permeability of the functionalised AuNPs and pNrf-2 complexes will be evaluated in a well-characterised in vitro transwell co-culture model; with cellular localisation examined using advanced microscopic techniques. The neuroprotective effects of inhibiting α-synuclein aggregation and upregulation of Nrf-2 antioxidant proteins using the functionalised AuNPs will be examined in a dopaminergic cell line. It is envisioned that u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accelerate the commercialization of RARX technology process in the global markets of ECOLOGICALLY FRIENDLY SILENT RUBBER PAVEMENTS' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Paving industry sector faces nowadays different challenges as the need for less maintenance, more silent and more environmental friendly pavements.  The use of crumb rubber (CR) derived from end‐of‐life tires (ELTs) in bituminous mixtures replies to all these needs however its wide implementation has not been extended due mainly of the following  barriers that prevent its wide  implementation are: i.A crumb rubber alone cannot be placed directly into the mixes (dry method) because it will swell and absorb the bitumen causing raveling in the roadsii.The wet method works well but requires that every contractor buys expensive equipmentiii.If crumb rubber is used in terminal blends it is essentially a waste of product because over time it becomes all digestedThe solution proposed in this initiative to overcome these barriers is the use of use of reacted and activated rubber that it can be used directly into the plugmill of a contractor’s plant.  The SILENT RUBBER PAVEMENTS project main goal is to market uptake and achieve a wider deployment of the RARX technology, based in a patent of CONSULALPV, that has the best of both methods:•Easy to apply and use as in the “dry method”•Performance and cost effectiveness beyond that of the “wet method”  To enter in the global market, two large companies (Valoriza SM- Composan) have made an agreement with a specialized SME (Consulpav, a first industrial applicant) who has developed  and patented the RARX technology to exploit at European level.  SACYR, a multinational pavement construction company present in more than 20 countries, will be the responsible for the pilot construction in different climate and evaluation. Our distributor in Italy, FHL group will assist the consortia in internationalizing our commercialization strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Composite tool for winglet manufacturing' in the context of a Horizon 2020 call.

assistant: **Objectives**

An all composite tool for the manufacturing of winglet pairs will be designed and manufactured. The tool will be self heated. Separate cavities will be fed by a single injection system, ensuring identical quality and dimensional tolerances for both winglets.


**Keywords:** Composite tool, winglet, process monitoring, process optimisation, life cycle analysis, tool design