RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced Thermal Analysis System in Poland' (ATHAS-POLAND).

assistant: **Innovation**

The project will enable reintegration into the European Research Area of a Polish-born scientist Dr Marek Pyda who has worked in the USA for the last 13 years. Dr Pyda is a widely recognised researcher in the field of physical chemistry of polymers. He was an important contributor and currently is the Director of a unique laboratory of advanced thermal analysis of polymers (ATHAS) located at the University of Tennessee in Knoxville (USA).The project involves:(i) Dr Pyda's return to his native Poland to undertake a scientific position in academia(ii) transfer of the ATHAS laboratory from the USA to Rzeszow, Poland (all the equipment at Dr Pyda's disposal, together with a large and unique data base of thermal properties of polymers and related materials),(iii) advanced and complex research on thermal properties of polymers and polymer-related materials, including molecular and full physical and chemical interpretation of material properties.Dr Pyda will conduct his research at the Faculty of Chemistry, Rzeszow University of Technology (RzUniTech). The Faculty has a strong polymer research group with well-established scientific position, who co-operate with regional, national and international scientific and industrial centres. Dr Pyda's knowledge and experience will significantly add to the scientific quality of the group and the research it will conduct.The project will enable:(i) transfer of scientific knowledge and know-how from the USA to Europe,(ii) establishing a laboratory of a scientific potential unique in Europe,(iii) development of new lines of research at RzUniTech.The nature of the research proposed in this project will make it of use for basic and applied science, as well as for the industry. The continuity of the research will be assured by the University a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Roles for Abelson-interactor (Abi) proteins in cell polarity and cancer progression' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Primary tumour cells that detach and become migratory are the basis for metastatic cancer. Metastatic cells removed from tumours show dramatic increases in their rates of motility, indicating that changes in cell motility may be a requisite step in the progression of tumours towards malignancy. I have been studying factors that regulate lamellipodial protrusion and cell migration in vitro. I propose to study the regulation of mammalian cell migration and the consequences of misregulating cytoskeletal dynamics on oncogenesis.The central hypothesis is that an emerging family of cytoskeletal-regulatory proteins (Abi/NESH proteins) acts on the cytoskeleton to control cell polarity and cell proliferation. I have initiated a molecular and genetic analysis of A bi/NESH function in cells and in vivo. Abi/NESH activity will be modulated by complementary over-expression and RNAi-mediated loss-of-function studies measuring the cellular effects on cytoskeletal dynamics, anchorage-independent growth, and the incidence of tumour metastasis. This research will be conducted at the Instituto Gulbenkian de Ciencia (Oeiras, Portugal) where I will establish a state of the art cell biology program dedicated to quantitative live cell dynamics analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploration of strains in synthetic nanocrystals' in the context of a Seventh Framework call.

assistant: **Objectives**

I plan to grow nanometre-sized crystals in confined geometries to examine the strain distributions that result.  The crystal growth will employ lithographic processing techniques, made possible by the local expertise in the central clean room facilities of the London Centre for Nanotechnology.  My group is world-leading in developing a method called Coherent X-ray Diffraction (CXD).  Our CXD strain images of a Pb nanocrystal were published in Nature in 2006.  CXD is sensitive to strain because the X-ray diffraction pattern surrounding a Bragg peak can be decomposed into symmetric and antisymmetric parts.  To a good approximation, the symmetric part can be considered to come from the real part of the electron density, while the antisymmetric part is a projection of the strain field.  The phasing of the data is a critical step that uses a computer algorithm, developed by us, which acts like the lens of a 3D X-ray microscope.  CXD works best for nanocrystal sizes between 40nm and 5µm, for crystals strongly attached to substrates and for isolated, fiducialised arrays of crystals that can be cross-referenced with other techniques.  To create nanocrystals in this size range, we will use both a bottom-up self-assembly of materials deposited onto  templated substrates, designed to introduce strain, and a top-down  nanosculpture  approach will use lithography techniques to create strain patterns in crystalline materials associated with shapes that are carved into them.   The interpretation of the images is the main intellectual output of the project.  This will be compared with finite element analysis, and the deviations interpreted as unique properties attributable to the nanoscale.  All project participants will work in a design, creation, analysis, interpretation, update cycl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Effect of the local isoform of IGF on epidermal stem cells, aging and skin diseases' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The skin is the first line of defence to protect the body from dehydratation, injury and infection. The epidermis, the outer covering of the skin, is maintained throughout life by stem cells. The Rosenthal group has recently reported that a local isoform o f IGF-1 (mIGF-1) is able to enhance both skeletal muscle and heart regeneration, inducing the proliferation of a specific cell population in the bone marrow and enhancing their recruitment to the site of injury and their fusion with existing myocytes. In t his context, we will study the effect of specific expression of mIGF-1 in the epidermis by generating transgenic mice expressing mIGF-1 in a tissue specific and inducible manner.We will compare the gene expression profiles of the mIGF-1 expressing skin with the data on m-IGF-expressing muscle already available, to see how much of the muscle regenerative response is recapitulated in the epidermis. After analysing the action of mIGF-1 on the regeneration and proliferative capacity of the skin, we will identify the molecules mediating such an effect, mainly focusing on the capacity of mIGF-1 to modify the secretion of growth factors and cytokines that may regulate the behaviour of surrounding cells. We will determine whether mIGF-1 expression results in increased stem cell proliferation in vivo, whether mIGF-1 enhances the recruitment of epidermal stem cells to the site of injury and will determine the capacity of these stem cells to differentiate and engraft different tissues. We will analyse the ability of epidermal mIGF-1 to interfere with scar formation or to enhance extra cellular matrix destruction and will study the effect of mIGF-1 expression on skin aging.Finally, we will study whether mIGF-1 expression in the epidermis protects mice from developing immune-ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Neuroprosthesis user interface based on residual motor skills and muscle activity in persons with upper limb disabilities'.

assistant: **Concept**

In this project, I will develop a user interface that will allow persons with upper limb disabilities to control neuroprosthesis using their residual motor skills. This interface will consist of inertial sensors (IMU) and electromyography (EMG) that are capable of capturing movements and muscle contraction that even persons with high tetraplegia still can control. The interface will also be able to learn different inputs, customizing the system for each user. This requires techniques of machine learning, making it flexible and indicated for users with different upper limb disabilities, such as spinal cord injury, stroke and multiple sclerosis. The machine learning techniques will classify the user inputs into desired commands, working as an intention decoder. The interface will be used to control a hybrid upper limb neuroprosthesis based on surface functional electrical stimulation (FES) and a semi passive mechanical orthosis. The system will allow users to perform activities of daily life independently. To my knowledge, such a hybrid system with FES, and controlled by an interface based on IMUs, EMG and machine learning techniques is novel. I will be working with Christine Coste, an expert in neuroprosthesis for disabled persons, and her interdisciplinary team, which consist of engineers and health professionals with vast experience in neurorehabilitation. This fellowship will enable the transfer of knowledge between her team and me through experiments with real patients and mutual training. I can contribute to the team with my expertise in machine learning and control, whereas they have vast access to patients, medical doctors, mechanical designers, electrical stimulators and sensors. This project is going to be an important step in my career as expand my network in E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Shaping EUROpean policies to promote HEALTH equitY' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Health inequities have been increasing in Europe, particularly in a context of an ageing society and economic crisis. In countries with different levels of infrastructures and health system preparedness, inequities create significant policy challenges.The main goal of this project is to advance knowledge of policies that have the highest potential to enhance health and health equity across European regions with particular focus on metropolitan areas. To achieve this goal, the project will develop tools – based on a population health index – to evaluate the health and wellbeing of European population. This index will be informed by evidence on the relationship between multiple determinants (e.g. demographic, social, economic, environmental, lifestyle, and health care) and health outcomes in the past 15 years. It will be constructed using a multicriteria model structure, following a socio-technical approach: integrating the technical elements of a multicriteria value model and the social elements of interdisciplinary and participatory processes. The index will be applied to evaluate the population’s health in 273 NUTS 2 European regions and 9 selected pilot metropolitan areas (covering populations of 28 EU countries). The space-time analysis and comparison of the population health index will be enabled by a user-friendly web-based Geographic Information System.The population health index will be used to foresee and discuss the impact of multilevel policies and combinations of policies in population health and health equity across European regions, thus providing a basis for policy dialogue. Multicriteria resource allocation models, conflict analyses, analysis of policies’ feasibility, and scenario analyses will then assist in providing evidence on which policies have the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Developing Data-Intensive Cloud Applications with Iterative Quality Enhancements' (DICE).

assistant: **Innovation**

The rapid increase in demand for data-intensive applications capable of exploiting Big Data technologies such as Hadoop/MapReduce, NoSQL, cloud-based storage, and stream processing is creating massive growth opportunities for European independent software vendors (ISVs). However, developing software that meets the high-quality standards expected for business-critical cloud applications remains a barrier to this market for many small and medium ISVs, which often lack resources and expertise for advanced quality engineering.DICE will tackle this challenge by defining a quality-driven development methodology and related tools that will markedly accelerate the development of business-critical data-intensive applications running on public or private clouds. Building on the principles of model-driven development (MDD) and on popular standards such as UML, MARTE and TOSCA, the project will first define a novel MDD methodology that can describe data and data-intensive technologies in cloud applications. A quality engineering toolchain offering simulation, verification, and numerical optimisation will leverage these extensions to drive the early design stages of the application development and guide software quality evolution.DevOps-inspired methods for deployment, testing, continuous integration and monitoring feedback analysis will be used to accelerate the incorporation of quality in data-intensive cloud application both in public and private deployments, enhancing the capability of small and medium European ISVs to enter the Big Data market.


**Keywords:** Quality, reliability, efficiency, safety, Big data, Cloud computing, UML, MARTE, TOSCA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of an Innovative Industrial Bioreacting and Fermentation Process producing an Organic Insect Repellent-Fertilizer for Ecological farming' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Our idea is to develop an “all-in-one” organic smell-free fertilizer and insecticide to increase yield of eco-crops, reduce costs, and reduce emissions to air & water that are common while using inorganic pesticides and fertilizers or fresh manure. The production of smell free fertilizer will be based on anaerobic fermenting of manure in a bioreactor. The insecticide production will be based on growing specific cyanobacteria proven to be insect repellent to cabbage root fly in a fermentation reactor for subsequent drying to a flake state. The final stage will consist of mixing the solid fertilizer with the small amounts of cyanobacterial flakes (1-10 kg flakes/100 ton fertilizer) to produce granules by protrusion technology with the moisture content of 5-10%. No industrial process can currently manufacture this combined insect repellent-fertilizer product due to lack of carrier substance for the insect repellent that also will add fertilizing value and delayed release. There exist currently no efficient organic product to control adult cabbage root fly. The following novel and innovative features will be developed: • Development of a drying technology for the cyanobacteria biomass to flakes with humidity 15-20% • Production of smell-free solid organic fertilizer from manure in <2 weeks/batch, humidity 20-30% • Development of an innovative and novel extruder chamber with an in-line humidity sensor feedback controlled heating and with vacuum drying of mixed fertilizer/insecticide to ensure rapid drying from ~20% down to 8 ± 2% before entering the compression zone of the extruder allowing a controlled co-extrusion with starch obtaining a fixed coating thickness with <10% variance • Development of a co-extrusion process to produce starch-coated pellets with a moisture conte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Decoding the host-pathogen interspecies crosstalk at a multiparametric single-cell level' (DecodingInfection).

assistant: **Concept**

Bacterial pathogens remain a significant threat to global health, necessitating a better understanding of host-pathogen biology. While various evidence point to early infection as a key event in the eventual progression to disease, our recent preliminary data show that during this stage, highly adaptable and dynamic host cells and bacteria engage in complex, diverse interactions that contribute to well-documented heterogeneous outcomes of infection. However, current methodologies rely on measurements of bulk populations, thereby overlooking this diversity that can trigger different outcomes. This application focuses on understanding heterogeneity during the first stages of infection in order to reduce the complexity of these interactions into informative readouts of population physiology and predictors of infection outcome. We will apply multiparametric single-cell analysis to obtain an accurate and complete description of infection with the enteric intracellular pathogen Salmonella of macrophages in vitro, and in early stages of mice colonization. We will characterize the molecular details that underlie distinct infection outcomes of individual encounters, to reconstruct the repertoire of host and pathogen strategies that prevail at critical stages of early infection.We propose the following three objectives: (1) Develop methodologies to simultaneously profile host and pathogen transcriptional changes on a single cell level; 2) Characterizing the molecular details that underlie the formation of subpopulations during macrophage infection; and (3) Determine how host and pathogen encounters in vivo result in emergence of specialized subpopulations, recruitment of immune cells and pathogen dissemination.We anticipate that this work will fundamentally shift our paradigms of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Concept Visualization for Enhanced Explainability in Tabular Deep Learning' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The EU's GDPR and the new EU AI Act impose strict requirements on AI systems, especially in high-risk domains like healthcare. These regulations demand transparency and meaningful explanations for automated decisions to ensure adequate human oversight. State-of-the-art eXplainable AI (XAI) methods, such as LIME and SHAP, attempt to meet these demands with low-level explanations. However, these methods often yield inconsistent and decoupled results from high-level concepts that domain experts like physicians use in decision making. In contrast, Deep Learning (DL) models that generate concept-based explanations during training offer more robust and consistent outcomes. Despite their promise, concept-oriented DL models for tabular data remain underdeveloped, with the recent Tabular Concept Bottleneck Models (TabCBMs)—a family of interpretable, self-explaining DL models designed to learn and articulate high-level concept explanations for tabular data as an emerging yet unexplored solution. CONVEYTab will advance TabCBMs by creating the first Visual Analytics (VA) framework that enhances interactivity and tests their real-world applicability. This framework will be realized through several VA systems tailored for medical professionals, enabling them to create, refine, explain, and compare DL model concepts in real time. This will ensure AI predictions are transparent, aligned with domain expertise, and compliant with EU regulations. CONVEYTab adopts a strong interdisciplinary approach, integrating expertise from life sciences, computer science, and cognitive science to meet the needs of the public sector and broader society. The research will be conducted at Utrecht University's Information and Computing Sciences Department under the supervision of Prof. Dr. Alexandru C. Tel