RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CustOms exteNded iNteroperablE Common informaTiOn shaRing environment' (CONNECTOR).

assistant: **Concept**

CONNECTOR’s vision is to contribute to the European Integrated Border Management (EIBM) and to the EU Customs Action Plan by addressing the need of close cooperation between Customs, Border and Coast Guard Authorities within the current and upcoming challenging and demanding environment of borders’ control by further involving Customs to the Common Information Sharing Environment (CISE) network and Enhanced Common Information Sharing Environment (e-CISE) through the proposed Customs Extended Common Information Sharing Environment (CE-CISE). CONNECTOR aims for the first time to suggest an integrated, common and shared risk assessment approach for all Border Management Authorities, considering the pan-EU common risk indicators per end user group (Customs, Border and Coast Guards Authorities including FRONTEX), to ensure external EU border and secure EU citizens from cross-border crime and/or secure the seamless flow of travellers, as recommended in the multiannual strategic policy document . Thus, in this sense, CONNECTOR proposal, will design and develop the CONNECTOR system as an interoperable technical environment, ensuring close and practical cooperation and information exchange at all levels. The design and the development of the CONNECTOR system will be based on the analysis of current policy initiatives in EU level (directives, policy and staff documents, guidelines etc.) along with needs, gaps and future views of the end-user groups going beyond previous initiatives (ANDROMEDA, MARISA, EFFECTOR, etc.), complying with the Societal, Ethical and Legal (SoEL) requirements and regulations, following the SoEL-by-design principle. The CONNECTOR system will be validated in real operational environment, based on well-defined National, Cross-border and Transnational use cas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The combinatorics of KPZ at positive temperature', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Kardar-Parisi-Zhang equation (KPZ) was introduced in 1986 as a universal model to capture statistics of a wide range of physical phenomena such as growth of interfaces or turbulent fluids. Remarkably fluctuations of this class of systems fall out of the scope of the classical central limit theorem. Understanding these phenomena has driven a tremendous activity in rigorous mathematics leading to groundbreaking theories or even to whole new fields such as that of Integrable Probability, where this proposal belongs. Since the seminal work of Johansson (1999), it is understood that systems in the KPZ class are governed by distributions coming from random matrix theory. So far, a framework with clear ""determinantal structure"" has been created to tackle models at ""zero temperature"". Progress in positive temperature setting, including the KPZ equation, only came during the last decade. Insights from many different fields (combinatorics, symmetric functions, etc) into probability, allowed to treat one-point statistics of certain systems at positive temperature. In all instances a mysterious determinantal structure, whose origins elude understanding, appears to govern (so far only) one-point statistics. This project aims to reveal the deep foundations of integrability of KPZ models at positive temperature and extend its scope. This will allow to settle the solvability in situations that are currently out of reach such as restricted spatial geometries and multi-point correlations. To achieve this we will follow a new route producing combinatorial mappings of positive temperature systems to purely determinantal ones. Our approach will make novel uses of methods from combinatorics and integrable systems (via the Yang-Baxter toolbox) and will create new dynamics linking inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'West Nile Integrated Shield Project: Epidemiology, Diagnosis and Prevention of West Nile Virus in Europe' (WINGS), addressing dissemination and exploitation.

assistant: **Impact**

The world is facing a variety of viral infections of high pathogenic potential. These are either novel or formerly only endemic in specific areas of the world. It is intrinsic to such emerging diseases that actions to prevent and fight them must be taken while the number of infections is still relatively low and geographically restricted. Therefore, research efforts are required well before large outbreaks occur. In addition, effective surveillance networks for a given emerging disease must be established in time. Only with tools for treatment and control (such as vaccines) it will be possible to avoid major uncontrolled outbreaks. This proposal aims at the development of these tools for the control and prevention of one of the most threatening vector-borne emerging diseases, West Nile Fever, caused by West Nile Virus (WNV), which has recently spread through North America. Although the viral strains are similar in America and Europe, different conditions for a WNV epidemic have to be taken into account, like insect vectors, reservoir hosts (birds) and their endemic virus populations plus specialities of European climate and geography. To achieve the goals of the call and to make a significant impact in the enhancement of Europe´s preparedness to WNV, the consortium has defined three major scientific and technical objectives. Firstly, to develop a diagnostic system for WNV-infections, which has no cross-reaction with other common flavivirus infections. Secondly, to develop a vaccine for humans and last but not least to establish a scientific network to collect, investigate and standardize biological data associated with WNV records using standardized methods. Several European Institutes supported by US scientist experienced with the North American outbreak will be collab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A density functional theory study of the early steps in radiation damage' (QS4RADAM), addressing dissemination and exploitation.

assistant: **Impact**

Radiation damage on molecular scale commonly occurs due to exposure to UV light or ionizing radiation as applied e.g. for food preservation, waste water treatment, medical treatments, or originating from the sun. Initially, radiation creates highly reactive electronic defects such as electron holes and excess electrons.These defects can attack organic molecules directly or are converted to intermediate free radicals that react rapidly with most molecules and are responsible for e.g. DNA damage. Free radical scavengers provide protection by capturing these highly reactive species. We propose to study the chemistry of electronic defects in aqueous solution such as formed by irradiation using parameter free, atomistic and electronic modelling based on density functional theory.The insight gained from this modelling should complement the vast body of experimental research. A computational approach may in particular help rationalizing the transient electronic states playing a role during the early steps of radiation damage, which are less accessible to experiment. We will study the formation of solvated electrons, hydroxyl radicals and other small radicals in water, and investigate the process in presence of free radical scavengers.The ultimate aim is the simulation of radiation damage to DNA in aqueous solution. Given the extended nature of the electronic defects and high transient mobilities following photoionization or radiolysis, the simulated systems will have to be large, requiring highly accurate and fast electronic structure calculations for up to several thousand atoms.Moreover, the strong coupling to molecular motion in finite temperature liquid solutions leading to relaxation and solvation can only be treated by molecular dynamics techniques, and requires simulati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of an artificial information system' (XNA) targeting Seventh Framework.

assistant: **Abstract**

Artificial genetic sequences have become an important tool for the development of new therapeutics but may also define a trait of technological innovation. The possibility to synthesize genes, plasmids and chromosomes combined with the possibilities of directed mutagenesis and genetically reprogramming organisms and directing their evolution will become a crucial issue in synthetic biology. The uniformity of genetic alphabets, the universality of the genetic code, the ubiquity of genetic interchanges and the risks of genetic pollution cannot be overlooked.  On the other hand, synthetic nucleic acids will become more and more important as potential new drugs.It is proposed to develop an additional type of nucleic acids for the use as information system for the propagation of specific information of non-natural origin. It is the aim of the project to contribute to the development of an artificial genetic system orthogonal to the natural system that can be used as well in synthetic biology as in medicine.Therefore we have to select & develop the appropriate chemical and enzymatic tools. This means (chemically) the selection of unnatural nucleic acids, their precursors and their modification for uptake in bacteria. Specialized polymerases as well as ligases will need to be developed for this purpose. The goal of the project is to design and synthesize a first orthogonal plasmid and new series of aptamers. A first application is the production of new therapeutics. This is a multidisciplinary project involving mainly chemistry and biotechnology. The general project architecture is to explore experimental progress in vivo and in vitro to reach the final assembly of an XNA episome.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Time-Delay PhotoIonization of Core-Orbitals in the Molecular Frame' to be submitted under Horizon Europe.

assistant: **Abstract**

The recent development of broadband coherent extreme ultraviolet sources makes it possible to measure dynamics with attosecond resolution (1 attosecond = 10-18 s). This time scale is associated with the electron dynamics and more particularly to the electronic correlation in various systems, from atoms and molecules to solids. Generating and controlling processes on this time scale then gives the opportunity to develop new promising applications in chemistry and biology that can have high impact in society.TD-PICO-MF aims at studying electronic correlation through the measurement of the photoemission delay of core-orbital electrons in a laser-controlled molecular system. For this purpose, TD-PICO-MF brings together advanced technologies from the attosecond interferometry field and laser-induced alignment field, in order to resolve both spatially and temporally the photoemission process.In particular, the research project proposes to study, as a prototype, the photoemission from the 4d core-orbitals of the iodine atom in iodine monochloride (ICl) molecules in gas phase. The measurements will be realized during different laser controlled configurations of the molecular system e.g., during its alignment, orientation and dissociation. The expected impact is to gain a global picture of the influence of the molecular cationic potential during a chemical reaction and to evidence the role of electronic correlation through the measurement of 3D-scattering phase maps in the molecular frame.TD-PICO-MF will utilize existing, and forge new, international collaborations between experiment, theory and academia in order to tackle this complex problematic. The results of our work will be made globally available and presented to the general public. The post doctoral fellow will bring to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PRocess-based climate sIMulation: AdVances in high resolution modelling and European climate Risk Assessment' (PRIMAVERA), addressing dissemination and exploitation.

assistant: **Impact**

The goal of PRIMAVERA is to deliver novel, advanced and well-evaluated high-resolution global climate models (GCMs), capable of simulating and predicting regional climate with unprecedented fidelity, out to 2050. This capability will deliver innovative climate science and a new generation of advanced Earth System Models. Sector-specific end-users in policy and business will be identified and engaged individually, with iterative feedback, to ensure that new climate information is tailored, actionable and strengthening societal risk management decisions.These goals will be achieved through the development of coupled GCMs from seven groups across Europe, with sufficient resolution to reproduce realistic weather and climate features (~25km mesh size), in addition to enhanced process parameterisation. Thorough assessment will use innovative process-based metrics and the latest observational and reanalysis datasets. Targeted experimental design will reduce inter-model spread and produce robust projections, forming the European contribution to the CMIP6 High-Resolution Model Intercomparison Project, led by PRIMAVERA. It is the first time that high-resolution coupled GCMs will be used under a single experimental protocol. Coordination, and the underlying process-understanding, will significantly increase the robustness of our findings. Our new capabilities will be used to improve understanding of the drivers of variability and change in European climate, including extremes, since such regional changes continue to be characterised by high uncertainty. We will also explore the frontiers of climate modelling and of high performance computing to produce simulations with a reduced reliance on physical parameterisations. These will explicitly resolve key processes such as ocean eddie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SESAME - Software Defined Wireless Backhaul for Small Cells' to be submitted under Seventh Framework.

assistant: **Abstract**

The forecasted traffic growth in mobile networks is one of the biggest challenges faced by the mobile industry. In addition, declining average revenues per user (ARPUs) and rising costs of ownership increase the difficulties for service providers to fulfill this upcoming demand. Densifying mobile networks by means of adding small cells, which have a limited footprint but high data rates, is seen as the most promising way to cope with this increasing demand. However, one of the biggest challenges to be solved for a successful deployment of such small cells is the question of backhauling, especially when in many cases the backhaul network is expected to be wireless.In SESAME, we plan to study how such a small cell wireless backhaul should be designed. In particular, we propose to apply software defined networking (SDN) techniques to the design of the wireless backhaul, which should allow service providers to: i) have a common management framework for a potentially heterogeneous backhaul network, ii) allow a flexible and dynamic deployment of network services running on top of the backhaul network, and iii) enable new business models such as those involving the sharing of the backhaul network among different service providers, hence reducing capital and operational expenditures. The work methodology followed in SESAME will be an experimental research approach, where the designed concepts and protocols will be evaluated by means of simulations and prototyping.SESAME will potentially impact relevant European and international stakeholders in the software defined networking and in the wireless backhaul arenas. Dissemination and exploitation of the results by means of publications, standard contributions and further collaborations with interested industrial partners is one of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Antibiotic resistance-free meat and dairy products' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Antibiotic resistance is an increasingly serious European and global health issue both for humans and animals, limiting the treatment options — or making them less effective — while decreasing the quality of life. It also entails serious economic consequences in terms of rising health care costs and productivity losses. The presence of antibiotic-resistant micro-organisms in the food chain is a current problem since certain bacterial species traditionally considered “not dangerous” for human health may become “dangerous” because they act as a genetic reservoir, transferring information regarding resistance to antibiotic molecules to other bacteria which, instead, could be dangerous for human health. Through our specialization, our company can make an important contribution to combating antibiotic resistance. In fact, Sacco srl is an Italian SME that produces and markets food-grade ""starter"" cultures. The goal of this project is to help fight the spread of antibiotic resistance through the food chain. Instead of using chemicals (biocides) whose long-term impact is not known, we intend to achieve this aim through biotechnology.We would in this way stay ahead of regulations, which we know are currently under preparation, and gain a competitive advantage that will translate into significant company growth in terms of personnel and turnover.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Evolutionary divergences of cadherin-mediated cell contacts and their impacts on morphogenesis'.

assistant: **Innovation**

As a zygote develops into a multicellular organism, cell contacts are crucial to shape the embryo. Metazoans utilize Cadherin proteins for adhesion in which the extracellular domains establish cell contacts and intracellular domains mechanically couple the cytoskeleton. The nature of the cell contact is critical for defining cell shapes and the physical properties of the tissue. While the intracellular domain is highly conserved, the architecture of their extracellular domains varies widely across species. How these differences influence cell contacts at the microscale and morphogenesis at the macroscale remains largely unexplored.In this study, I will conduct a comparative analysis of cell contacts using widely diverse Cadherin extracellular domains from vertebrates, cephalochordates, arthropods, and cnidarians. I will express these exogenous Cadherins in zebrafish embryos and test their impacts on cell contacts at three levels. First, I will characterize Cadherin-mediated contacts at the single-cell level using biomimetic supported lipid bilayers. Second, I will quantify adhesion strength and cell contact dynamics in cell doublets. Finally, I will assess how different Cadherins influence morphogenetic movements at the tissue level in zebrafish development.Together, this work will uncover fundamental principles of Cadherin extracellular domain evolution and its impact on cell adhesion. In this work, I will develop tools to carry out comparative analyses of cell adhesion which can potentially be transferred to other organisms. This work will help bridge the gap between molecular evolution, cell mechanics, and large-scale morphogenetic processes, revealing how evolution may utilize adhesion mechanisms to drive the diversity of life forms.


**Keywords:** evo-devo-cell bi