RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart Core/shell nanorod arrays for artificial skin' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The replication of the circle of information coming from the environment, to the skin, to an action mediated by the brain, requires a lot of advances in smart technology and materials development. Embedding sensors in smart architectures that record the stimulus from the environment and transform it into action is the objective of artificial skins. At the moment, different sensors have to be implemented in the artificial skin matrix for each stimulus. The goal of this project is to develop a single multi-stimuli responsive material, which would allow a simplification of the artificial skin and enable unprecedented spatial resolution. The material will be comprised of a smart core, responsive to temperature and humidity, and a piezoelectric shell for pressure sensing. The swelling of the smart core upon stimuli will be sensed by the piezoelectric shell and produce a measurable potential. This architecture will be achieved thanks to the use of novel vapor-based technologies for material processing that allow fabrication at the nanoscale. The advantage of using a dry, vapor-based, polymerization for the smart core is that it will be possible to cumulate different functionalities and engineered composition gradients, which are difficult to obtain by conventional synthesis. Nano-structuration of such materials in core-shell site-specific arrays will allow to create a sensing network with spatial resolution down to 1mm and lower. The network will respond to the stimuli coming from the environment and recognize them in terms of location and type of stimuli. The successful execution of the SmartCore project will have a strong impact in the design and production of future structures, with consequences in sensoring, biotechnology and tissue engineering.


**Keywords:** Chemical V
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Knowledge-driven fine-tuning of perovskite-based electrode materials for reversible Chemicals-to-Power devices'.

assistant: **Innovation**

We target a knowledge-based methodological entry to the finding of new generation electrode materials based on perovskites for reversible SOFC/SOEC technologies. The latter are archetypal complex systems: the physico-chemical processes at play involve surface electrochemical reactions, ionic diffusion, charge collection and conduction, which all occur timely within a very limited region. Hence, true in-depth understanding of the key parameters requires characterisation at the right place, at the right time frame and under the proper operating conditions. The price to pay for achieving this multiply-relevant characterisation is the involvement of non-trivial, advanced characterisation techniques. Multi-scale modelling will contribute to turn experimental datasets into a genuine scientific description and make time-saving predictions. In KNOWSKITE-X, the coupling between theoretical and experimental activities is made real by the choice of partners, who are all active in genuinely articulate theory and practice to understand active systems. To provide unifying concepts and to widen the project’s outcomes, intensive collaboration with knowledge discovery using machine-learning and deep learning methods is planned and AI-enabled tools will be used to compensate the smallness of relevant datasets. Such efforts are intended in view of building strong correlations capable of establishing robust composition-structure-activity-performance relations and hence, lead the way to knowledge-based predictions. By doing this, we also target the implementation of simplified testing protocols and tools operable by industrial stakeholders, which results can be augmented thanks to the knowledge-based pivotal correlations implemented during the project. To this end, dedicated efforts will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Research and Development in support of the GEMINI Initiative' under Horizon 2020.

assistant: **Concept**

GEMINI+ project proposal will be submitted to the European Commission addressing the 2016 Euratom call for proposals (deadline October 5th, 2016).GEMINI+ project will provide a conceptual design for a high temperature nuclear cogeneration system for supply of process steam to industry, a framework for the licensing of such system and a business plan for a full scale demonstration .It will rely on modular High Temperature Gas cooled Reactor (HTGR) technology, which is a mature technology with several industrial prototypes that have been constructed and operated in the world. Therefore the time scale for the industrial deployment of such nuclear cogeneration systems is the decade. With available materials and technology, such a system can provide steam to industrial steam distribution networks presently operating on industrial sites up to 550˚C, simply substituting to fossil fuel fired cogeneration plants, without any need for adaptation of the steam distribution infrastructure or of the industrial applications. In the longer term, HTGR technology can be further developed to provide higher temperature process heat.Based on its huge thermal inertia, its refractory fuel and core structural materials, on the use of helium, which is chemically inert, as coolant, and of a specific design limited to a few hundred Megawatts, modular HTGRs have a unique intrinsic safety concept preventing in any circumstances significant degradation of the nuclear fuel and consecutive radioactive releases, with no need of any human intervention. Beyond industrial cogeneration, the flexibility, robustness and simple design of modular HTGR will allow extending application of the system developed by GEMINI+ to small isolated electric grids, to electric grids with increasing proportion of intermitten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Photoactivatable Sensors and Blinking Dyes for Live-Cell, Single-Molecule Localization Microscopy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In this proposal, we introduce two new families of probes for live-cell super-resolution microscopy. The first class comprises small-molecule fluorescent sensors for detecting short-lived, small signaling molecules and active enzymes with single-molecule resolution. The spatiotemporal confinement of biological reactive molecules has been hypothesized to regulate various pathological and physiological processes, but the lack of tools to observe directly these microdomains of biochemical activity has precluded the investigation of these mechanisms. The ability to detect small signaling agents and active enzymes with nanometric resolution in intact live specimens will allow us to study the role of compartmentalization in intracellular signaling at an unprecedented resolution. Our studies will focus on detecting elusive reactive oxygen and nitrogen species directly at their sites of endogenous production. We will also investigate the subcellular distribution of protease activity, focusing on its role in non-apoptotic signaling.The second class of probes encompasses a palette of fluorescent dyes that switch continuously between dark and emissive forms. This dynamic equilibrium will enable the localization of single molecules in a densely labeled field without the need to apply toxic light for photoactivation. Based on a novel switching mechanism, we will prepare dyes of various emission wavelengths that blink in a controlled way. These dyes will allow us to perform, for the first time, super-resolution, multicolor, time-lapse imaging of live specimens over long time. Initial studies will focus on tracking a transcription factor that migrates from the endoplasmic reticulum to the nucleus to initiate a cellular stress response upon protein misfolding. These studies will provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'In cellulo cryo electron tomography study on the structural regulation of nuclear pore complexes by the Nup210 luminal ring' (ProtectNPC) targeting Horizon Europe.

assistant: **Abstract**

The nuclear envelope (NE) is a double-membrane structure that encloses and protects the genetic material in eukaryotes. It is intermitted by nuclear pore complexes (NPCs), which form channels across the NE and mediate nucleocytoplasmic exchange. High tension in the NE is known to invoke NPC dilation, involving structural changes of the NPC scaffold. It is unknown to date, which NPC constituents limit maximum dilation to prevent NPC disintegration under high NE tension, and if disintegration of NPCs can result in NE rupture and nucleocytoplasmic mixing. A putative candidate for protecting NPC structure under mechanical strain is the nucleoporin 210 (Nup210). It is upregulated in several cancers, emerging as a biomarker for breast cancer metastasis and important for cellular adhesion and migration. Nup210 mainly resides in the lumen of the NPC-associated NE und forms a luminal ring (LR), which surrounds the entire residual NPC. In the proposed project, I will assess the role of the Nup210 LR in maintaining NPC structure to prevent disintegration and potential NE rupture under mechanical strain. For this, I will apply focused ion beam milling, cryo electron tomography and advanced image processing techniques to control and Nup210 depleted human cells under differing conditions of NE tension. The comparison of NPC structures will reveal how the Nup210 LR contributes to NPC structural integrity on a molecular level. I will further resolve the conformational landscape of the Nup210 LR to determine whether it elastically accommodates NPC dilation and re-constriction. These structural studies will be complemented and functionally validated by analysing nucleocytoplasmic exchange and NE rupture in the presence and absence of Nup210 in cells. The insights into NPC scaffold integr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New materials from miscellaneous plastic products' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The project aims at developing new recycling methods and equipment able torecycle, by means of a mechanical treatment, mixed plastic products in bothdomestic and industrial waste, without prior separation, in order to develop a compound material under the form of a granulate suitable to substitute mouldingand extruding plastics currently used in industry; the product obtainedrepresents the raw material for moulding and extrusion processes through which different types of products are obtained (e.g. tanks, tiles, chairs, curbs...).The project starts from the very promising experimental results achieved by theprime proposer MSG in small scale lab. Conditions, which now need to be jointlyanalysed and tested together with a qualified board of European R&D performers (during the technical exploratory phase) in order to adequately plan thepossible industrial exploitation of results. The final results may lead to ahigh reduction of costs, due to the elimination of the separation phasenecessary to obtain mono-material plastic products and the consequent reductionof production time.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Coupled Nanocrystal Molecules: Quantum coupling effects via chemical coupling of colloidal nanocrystals' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Coupling of atoms is the basis of chemistry, yielding the beauty and richness of molecules and materials. Herein I introduce nanocrystal chemistry: the use of semiconductor nanocrystals (NCs) as artificial atoms to form NC molecules that are chemically, structurally and physically coupled. The unique emergent quantum mechanical consequences of the NCs coupling will be studied and tailored to yield a chemical-quantum palette: coherent coupling of NC exciton states; dual color single photon emitters functional also as photo-switchable chromophores in super-resolution fluorescence microscopy; electrically switchable single NC photon emitters for utilization as taggants for neuronal activity and as chromophores in displays; new NC structures for lasing; and coupled quasi-1D NC chains manifesting mini-band formation, and tailored for a quantum-cascade effect for IR photon emission.  A novel methodology of controlled oriented attachment of NC building blocks (in particular of core/shell NCs) will be presented to realize the coupled NCs molecules.  For this a new type of Janus NC building block will be developed, and used as an element in a Lego-type construction of double quantum dots (dimers), heterodimers coupling two different types of NCs, and more complex NC coupled quantum structures. To realize this NC chemistry approach, surface control is essential, which will be achieved via investigation of the chemical and dynamical properties of the NCs surface ligands layer. As outcome I can expect to decipher NCs surface chemistry and dynamics, including its size dependence, and to introduce Janus NCs with chemically distinct and selectively modified surface faces. From this I will develop a new step-wise approach for synthesis of coupled NCs molecules and reveal the consequenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'New bioactive agents based on natural products'.

assistant: **Concept**

More than 1 in 3 people in the EU will develop cancer during their lifetime. Despite huge investment, insufficient new bioactive molecules are emerging, and there is urgent need for a different approach to research in this area. Drawing inspiration from Nature, the Fellow will investigate natural products with anticancer potential. The objective of the IEF is to support the career development of a talented researcher, to improve and develop her skills in preparation for an independent scientific career. The research objectives are to exploit the medicinal activity in naturally occurring quinones in an interdisciplinary programme involving chemical synthesis of the natural compounds and analogues, and their biological evaluation, maximizing the synergy between the Fellow and the Host Laboratory. The objectives will be measured against: • development of innovative chemical routes to bioactive quinones, including natural products and analogues; • biological evaluation of novel compounds as potential therapeutic agents; • publication of high quality papers; • establishment of research collaborations between UK and Italian groups. The project brings together complementary scientific communities in research aimed at developing novel therapeutic agents, particularly for cancer. The substantial training element will be of huge benefit to the Fellow in establishing her independent academic career by complementing and reinforcing her medicinal chemistry background with synthetic organic chemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An intelligent exercise machine for measurable and motivational neuro-muscular rehabilitation therapy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Annually 8.45 million of European citizens (~13% EU population) require some form of rehabilitation, and the number is expected to increase due to the aging, the proliferation of diseases and accidents. Current rehabilitation devices fail to guarantee an effective therapy because of the lack of tailored training according to the patient needs, a therapist is required for each patient leading to long waiting lists, low self-training compliance, and the lack of precise data about patient’s evolution.At Robofit ApS (2013, Denmark) we have been working on the new therapy generation: Enjoint. It is a novel intelligent exercise machine for neuro-muscular therapy, that using Big Data and Cloud Connection, provides precise data about patient progress while adjusting the rehabilitation training according to the patient injury and progress. Furthermore, it increases the compliance of the rehabilitation program though self-motivation of the patients thanks its constant feedback.  Enjoint current prototype is a fully functional device (hardware, software running on iOS, and cloud connection) optimized for neuro-muscular rehabilitation of shoulder joint and surrounding muscles. It has proved to reduce €132/patient per session, save €25,781/patient by reducing sickness period benefit, and to improve an 87.5% patient’s compliance to the rehabilitation. We expect to internationalise our customer base entering by 2021 onwards across Norway, Sweden, Finland, Germany, the UK and France. Expected gross profits after 3 years of commercial exploitation are estimated at €8.35 Million, serving more than 1,100 clinics across Europe. Successful implementation of this expansion project will result in growth of our company by up to 10 employees.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Excision and outer boundary conditions for the Einstein equations' to be submitted under Sixth Framework.

assistant: **Abstract**

Gravitational waves are expected to open up a new window for Astronomy in the near future. Numerical simulations are essential for this effort. By combining the results of simulations of systems containing compact stars or black holes with observational data we can hope to probe the dynamics of strong gravitational fields. The results will have significant impact on our understanding of the Universe. With the exponential growth of computer power, the numerical simulations of astrophysical interesting situations are becoming feasible. However, fully 3D numerical relativity simulations of gravitational-wave sources such as binary black holes or neutron stars are plagued by numerical instabilities whose origin is elusive. Well-posed ness of the continuum problem has been identified as a key ingredient for numerical stability. In this research project we shall formulate boundary conditions (both at the outer boundary of the numerical domain, and at interior boundaries where black holes are excised), which are both consistent with the constraints And mathematically well posed. Well-posed ness proofs for problems with boundaries are limited to smooth surfaces. However, a global spherical grid has coordinate singularities on which are hard to overcome, and is not well adapted for simulating binary merger containing excised regions. We shall explore a Cartesian main grid with overlapping grids adapted to the outer boundary and excision boundaries. Our aim is to construct stable and consistent numerical schemes, including boundary conditions, for binary black hole or neutron star simulations. As we proceed, we shall develop the mathematical theory of well-posed constraint-preserving boundary conditions, and in parallel develop the overlapping grids method by studying a variety o