RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pathogenesis of Vibrio cholerae infection and persistence dynamics in the Horn of Africa.' (1994-1998) under Fourth Framework.

assistant: **Objectives**

* To yield new, crucial information on the pathogenesis of Vibrio cholerae infection as a necessary basis for creating effective vaccines: role and dual function of the zonula occludens toxin (ZOT) encoded by the V. cholerae filamentous phage CTX(.* To design dynamic models for persistence of primary infection events and secondary transmission of the infection in critical geographic areas for the recurrent spreading of the disease.Expected Outcome* The role of ZOT toxin in modulating biochemical modifications of tight junctions up to their disassembly in intestinal epithelium will be characterized;* ZOT diarrhoegenicity in comparison with cholera toxin will be established;* Environmental factors and genetic components regulating expression of zot gene will be identified;* The analysis of the microbiological and epidemiological data integrated into a geographic and demographic information system will identify determinants for maintenance of endemicity and for infection propagation. By combining these results with the pattern of genetic relatedness between the prevalent V. cholerae strains, dynamic models for persistence and transmission will be proposed as practical contributions for designing realistic cholera control strategies.The studies of pathogeneis of V. cholerae infection will focus on: 1) identifying the mechanisms of action of ZOT by intracellular signalling and cytoskeleton rearrangement; 2) establishing the effect of ZOT on water and electrolyte transport via the paracellular pathway; 3) analysing the regulatory system and functions of the zot gene by TnPhoA fusions and site-directed mutagenesis.The studies of cholera transmission will concern the screening of aquatic environments as possible V. cholerae reservoirs and epidemiological and microbiological inv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Upscaling of fluorographene chemistry for supercapacitor electrode material' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The world population is significantly increasing and its reliance on energy-based devices is higher than ever before. This leads to a continuous rise in global energy consumption. Considering that fossil fuel resources are strictly limited and have a detrimental effect on our environment, it is understandable that research focused on sustainable energy resources, coupled with suitable energy storage technologies, attracts an intense interest. In addition, the ever-growing number of electric bikes and cars, portable devices and sensors requires quickly rechargeable, long-life cycle and safe power supply. Supercapacitors belong to the group of energy storage devices that display significant advantages over batteries or fuel cells, such as high-power density, extralong cycle life, and a small size. They can store more energy than conventional capacitors; however, the energy they can store is approximately one order of magnitude lower than that of batteries.The preliminary data show that chemistry of fluorographene, which has been developed in the framework of ERC project 2DCHEM, can lead to efficient synthesis of graphene derivatives having properties suitable for supercapacitor electrode materials. This project aims to deliver the upscaling of an industrially-relevant one-chemical-step novel manufacturing process, based on chemistry of fluorographene, resulting in a supercapacitor electrode material. The as prepared novel covalent graphene derivative enables a significant boost in the gravimetric/volumetric energy density, without sacrificing the rate performance, i.e. power. A significant business opportunity will arise through implementing novel and cost-effective materials and processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The weyburn co2 monitoring project (weyburn).' (WEYBURN) under Fifth Framework.

assistant: **Objectives**

This project will enhance the knowledge and understanding of the underground sequestration of CO2, especially where associated with enhanced oil recovery (EOR), and develop and enhance monitoring techniques to ensure safe and stable underground storage. The proposed project will study and monitor the injection and sequestration of the CO2 at the Weyburn oil field (Saskatchewan, Canada) as an integral part of a long-term IEA-facilitated project. Injection of anthropogenic CO2, generated during coal gasification, will start late in 2000. If not used for EOR the CO2 would be vented to the atmosphere. It is anticipated that approximately 20 million tonnes of anthropogenic CO2 will be permanently sequestered underground during EOR.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SPACE-DATA ROUTERSFor Exploiting Space DATA' (2007-2013) under Seventh Framework.

assistant: **Objectives**

"Space-Data Routers"" is a project that has the potential to allow Space Agencies, Academic Institutes and Research Centers to share space-data generated by a single or multiple missions, in a natural, flexible, secure and automated manner. We develop a communication overlay modeled according to thematic context of missions, Ground Segment topological distribution, Agency policies and Application restrictions and requirements. We realize our model through the development of Space-Data Routers: a (Delay-Tolerant Networking) DTN-enabled device that: (i) incorporates the Space Agency administrative instructions and policies for data dissemination and resource utilization and (ii) integrates the DTN protocol stack with application, network and link layer protocols. We pay particular attention to ESA roadmap for Interplanetary Communications and implement a communication scheme that scales natively with future deployments in Space.  In essence, we promote the ultimate objective of most missions, which is to return space data, which, in turn, will be disseminated and exploited for the benefit of human scientific knowledge. Space-Data Routers form an overlay suitable for exploiting space data efficiently, which is, by definition, a major objective of all space missions and probably the most significant failure today.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Rise of Judicial Self-Government: Changing the Architecture of Separation of Powers without an Architect' in the context of a Horizon 2020 call.

assistant: **Objectives**

Many European states have transferred decision-making powers regarding court administration and the career of a judge from political bodies to special organs in which judges have a major say. Judicial councils and other bodies of judicial self-government (JSG) spread particularly quickly during the European Union (EU) Accession Process. However, the effects of these bodies are not fully understood, as the traditional descriptive and normative scholarship is not able to capture them. JUDI-ARCH will fill this gap and address the implications of this phenomenon for the “new” as well as “old” EU member states. The central research question of JUDI-ARCH is: how the rise of JSG has changed the concept of separation of powers? More specifically, the JUDI-ARCH proposal consists of three interrelated research aims. The first is to assess the impact of JSG on public confidence in and the independence, accountability, transparency and legitimacy of the domestic judiciaries of 14 European states and the two European supranational courts, both the actual and the perceived. The second aim is to examine what impact the rulings of the European Court of Human Rights (ECtHR) and the Court of Justice of the European Union (CJEU) have had on domestic judicial design and, vice versa, how has domestic judicial design affected the selection of judges of the ECtHR and the CJEU. The third overarching aim is to analyse the impact of JSG on the concept of separation of powers. A major innovation in our approach will be the integration of comparative legal perspective with sociological and political science approaches. We will conduct in-depth conceptual, qualitative and quantitative case studies on the impact of different models of JSG in both “new” and “old” EU Member States, including longitudi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New enzymatic oxidation/oxyfunctionalization technologies for added value bio-based products' (EnzOx2).

assistant: **Concept**

Sustainable production of chemical building blocks and other added value products from plant biomass is required for a bio-based economy. However, the biomass biorefineries should benefit not only from the use of renewable feedstocks but also from greener and more efficient bio-chemical technologies. Previous projects have shown the potential of oxidative enzymes in the production of some added value compounds from biomass components. Of special interest are still unexplored oxidation/oxyfunctionalization reactions (of sugar and lipid compounds) by microbial oxidoreductases, including new (self-sufficient) heme-thiolate peroxygenases. In this context, EnzOx2 plans to develop a 100% biochemical conversion of bio-based 5-hydroxymethylfurfural (HMF) into diformylfuran, a platform chemical, and 2,5-furandicarboxylic acid (FDCA), a plastic building-block. Oxidases (flavo and copper/radical) and peroxygenases will be used to perform the three-step oxidation of HMF to FDCA in a co-substrate and side-product free, one-pot conversion. On the other hand, highly (regio/stereo) selective hydroxylation of plant lipids (such as fatty acids, terpenes and steroids) by peroxygenases will be optimized for cost-effective production of flavours and fragrances (F&F), active pharmaceutical ingredients (APIs) and others. ENZOX2 aims to solve some main bottlenecks in these industrial processes by the use of bio-chemical tools (new/engineered enzymes and optimized biotransformations), to be later validated at the pilot/flagship scale. To attain this objective the consortium includes: i) two world leaders in industrial enzymes (Novozymes) and F&F (Firmenich); ii) two chemical SMEs producing HMF and chiral APIs (AVA-Biochem and Chiracon); iii) two specialized biotechnology SMEs (JenaBios and CLEA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FORest management strategies to enhance the MITigation potential of European forests' under Seventh Framework.

assistant: **Concept**

Forest management can lead to continuous carbon sequestration, while timber as a renewable energy source can used as a substitute for fossil fuel, thus multiplying this mitigation effect. FORMIT aims to develop forest management scenarios for carbon sequestration in Europe, including mitigation measures and management strategies for different regions, and accounting for trade-offs with other forest functions. FORMIT will bring new insights into options for carbon storage in forests accounting for historical management practices, regional differences, and management scenarios and modes of operation. This includes options for biofuel use, links between biodiversity conservation and management strategies, and economics of timber production. Mitigation encompasses carbon storage in forests, carbon in forest products, and substitution of fossil fuel. Stand and forest type estimates will be scaled up to a European-wide assessment using available forest inventory data. Forest management options aimed at mitigation will be proposed, accounting for trade-offs between forest functions, and including selection of tree species and mixtures, rotation and silviculture techniques. Based on current knowledge, the expected impact of climate change on tree growth and forest functioning will be assessed, accounting for site differences and regional climate change. In quantifying and analysing the trade-offs between carbon mitigation strategies and other forest functions, we will involve a user panel with representatives of major forest management agencies and associations in Europe. The panel will also provide input for a multicriteria analysis to identify consistent and flexible scenarios for forest management. The project will deliver management options and implementation strategies for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Role of Ozone in the Climate System' (1994-1998).

assistant: **Innovation**

Objectives : To determine the role of past and possible future changes in ozone in the climate system Brief Description of the Research Project : The project brings together observations, chemical modelling, radiative transfer studies, and climate modelling in a unified effort to understand the role of ozone in the climate system. An analysis of the ozone anomalies and their evolution will be produced and the analysis of ozone trends using re-evaluated ground-based ozone-sonde and satellite data will be updated. Using statistical models various quasi periodic or aperiodic natural phenomena will be isolated and filtered out. Two 3-d chemical transport models will be used to study the change in ozone in response to variations of ozone precursors. The study includes present and pre-industrial simulations as well as time-slice simulations for the 1960, 1970 and 1980 periods. The two models will be intercompared and the time-slice simulations will be compared to observations. A number of numerical experiments intended to study the sensitivity of stratospheric ozone to chemical and dynamical processes will be performed with a low-resolution spectral circulation model and a chemical transport model including a microphysics code for aerosol formation and growth. Radiative transfer codes will be used to compute the radiative forcing due to both observed and modelled ozone changes and the results will be intercompared. The models include a standard Malkmus narrow band model and two broad band models. A simplified and a comprehensive general circulation model will be used to calculate the climatic response to the ozone changes and to test the concept of radiative forcing as an indicator of climatic response. The vertical sensitivity of radiative forcing and climate response will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regional Ecosystems FOR Multiple-Energy Resilient Systems' under Horizon Europe.

assistant: **Concept**

The EU energy system strongly relies on centralised electricity generation and on fuel imports, with 95% of its oil and 84% of its gas consumption sourced from outside the EU. The REPowerEU Plan proposes a set of actions to reduce the EU’s dependence on fossil fuels and diversify its energy supply ‘well before 2030’. The three pillars of the plan are to ramp up the production of green energy, diversify our energy supplies, and reduce our demand for fossil gas, coal and oil. Renewable energy valleys are understood as decentralised renewable energy systems that offer a viable and efficient solution to these challenges mentioned above. By implementing a high degree of renewable energy sources as well as storage technologies and intelligent management algorithms for synergetic use of a wide variety of technologies, they can be 100% self-sufficient on a yearly basis. For the next 5 years, the REFORMERS project aims to develop, implement an exploit such an energy valley in the Boekelermeer next to the city of Alkmaar in the Netherlands, that serves as a living lab for testing and validating technologies, business models, stakeholder ecosystems, including industrial partners, DSO, the municipality, and residents, and user acceptance in real-life circumstances, in a peri-urban and industrial environment. Furthermore, the project aims to support the deployment of multiple self-sufficient energy valleys throughout Europe beyond the flagship in the Netherlands. Therefore, it will deliver a roll-out blue print and replication toolbox that encompass: (i) Energy System Design, (ii) Environmental Impact Assessment, (iii), Stakeholder Engagement and Social impact assessment, (iv) Governance and policy assessment, and (v) Business modelling, and allow other sites and regions to develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Delivery and On-Demand Activation of Chemically Synthesized and Uniquely Modified Proteins in Living Cells' (SynProAtCell).

assistant: **Concept**

While advanced molecular biology approaches provide insight on the role of proteins in cellular processes, their ability to freely modify proteins and control their functions when desired is limited, hindering the achievement of a detailed understanding of the cellular functions of numerous proteins. At the same time, chemical synthesis of proteins allows for unlimited protein design, enabling the preparation of unique protein analogues that are otherwise difficult or impossible to obtain. However, effective methods to introduce these designed proteins into cells are for the most part limited to simple systems. To monitor proteins cellular functions and fates in real time, and in order to answer currently unanswerable fundamental questions about the cellular roles of proteins, the fields of protein synthesis and cellular protein manipulation must be bridged by significant advances in methods for protein delivery and real-time activation. Here, we propose to develop a general approach for enabling considerably more detailed in-cell study of uniquely modified proteins by preparing proteins having the following features: 1) traceless cell delivery unit(s), 2) an activation unit for on-demand activation of protein function in the cell, and 3) a fluorescence probe for monitoring the state and the fate of the protein. We will adopt this approach to shed light on the processes of ubiquitination and deubiquitination, which are critical cellular signals for many biological processes. We will employ our approach to study 1) the effect of inhibition of deubiquitinases in cancer. 2) Examining effect of phosphorylation on proteasomal degradation and on ubiquitin chain elongation. 3) Examining effect of covalent attachment of a known ligase ligand to a target protein on its degradati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters'.

assistant: **Concept**

This project will develop an innovative therapeutic approach for the treatment of Cystic Fibrosis (CF). This condition originates from the defective function of the CFTR protein, a chloride and bicarbonate permeable transmembrane channel. This project will evaluate small molecules capable of facilitating the transmembrane transport of anions such as chloride and bicarbonate and will thus enable CF treatment by replacing the missing CFTR anion permeation activity. This represents an unexplored path in the treatment of CF and a paradigm shift with respect to current strategies searching for a cure for CF. Instead of focusing on the development of mutation-specific treatments, we plan to develop a therapy applicable to CF patients, regardless of the type of mutation they harbor. Thus, this therapeutic approach overcomes the limitation of current mutation-specific treatments and is applicable to CF patients in general.To achieve this goal we have set up a comprehensive program to validate a research concept and complete the preclinical development of a new lead compound, making it ready for early clinical development. A  rmultidisciplinary team of qualified researchers have been assembled to bring to conclusion a truly translational project from the synthesis of new compounds to validation on animal models.Cystic Fibrosis affects more people than any other rare disease. Therefore, it could be said, at least in quantitative terms, that CF qualifies as the main target of the topic. This project aims to complete the preclinical development of novel, innovative drugs based on a radically new concept in Cystic Fibrosis therapies. This result fully addresses the expected impact set out in the work programme of advancing the development of new therapeutic options for patients livi