RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Long-Term Advanced Propulsion Concepts and Technologies II' (LAPCAT-II), addressing dissemination and exploitation.

assistant: **Impact**

Lacpat II is a logical follow-up of the previous EC-project which has as objective to  reduce antipodal flights to less than 2 to 4 hours. Among the several studied vehicles, only two novel aircraft for a Mach 5 and 8 flight are retained in the present proposal.   Starting from the available Mach 5 vehicle and its related precooled turboramjet, assumed performance figures of different components will now be assessed in more detail, i.e.: ­ Intake design and performance ­ Environment friendly design of combustor ­ Nozzle design and performance ­ Structural analysis Once available, the vehicle performance will be re-assessed. The outcome will allow the definition of a detailed development roadmap.  Though the cruise flight of the Mach 8 vehicle based on a scramjet seemed feasible, the acceleration based on an ejector rocket was not. Integrated design of airframe and engine throughout the whole trajectory is the prime focus now to guarantee a successful design. A turbo-based engine will replace the former ejector rocket to assure better performance and fuel consumption during acceleration. Important points to be addressed to realize these goals are: - proper development and validation of engine-airframe integration tools and methodology - high-speed airbreathing cycle analysis - off- and on-design behaviour of engine and airframe - dedicated experiments to evaluate the design in various operation points Validated tool development should give solid confidence to propose a fully integrated vehicle to comply with the mission goals. Once defined, a roadmap will be defined with a step-wise approach to future development.  Finally, for vehicles flying at high speeds and high altitudes, limited know-how is available on the environmental impact. The influence of NOx and H2O onto t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Pioneering Heterogeneous Organometallic-Mediated Electrocatalytic Reactions'.

assistant: **Innovation**

This project pioneers the use of Heterogeneous Organometallic Mediated Electrocatalytic Reactions (HOMER) and our understanding thereof. Examples of electron transfer activation of C-H, C-Halide bonds and cycloaddition reactions of unactivated olefins are sought that are catalysed by appropriate combinations of electrochemically generated odd-electron (17-electron) organometallic “radical” complexes and 7-electron perhalogenated arylborane Lewis acidic radical species. The electrochemistry of a series of Group VI-IX transition metal half-sandwich complexes, empirically “Cp’M(CO)n” (where n=2 or 3 in order to satisfy the metal centre’s demand for an 18-electron configuration; Cp’ = η5-C5H4CO2R, where R = Me) will be explored both in the solution phase and covalently attached to an electrode surface. These chemically modified “HOMER platforms” will be exposed to a wide variety of hydrocarbon feedstocks during electrolysis, and evidence of  C-H/C-halide bond activation sought. Optimization of the HOMER catalysts will be attempted by systematically varying the ligands within the complex.This includes a study of the electrochemistry of Group IV to VIII transition metal complexes bearing at least 1 borylcyclopentadienyl ligand that incorporates a Lewis acid group into the HOMER catalyst.Novel perchlorinated arylboranes, (C6F5)3-nB(C6Cl5)n n=1-3 “BArCl” recently reported by the PI and co-workers will be examined for their activity in Frustrated Lewis Pair (FLP) activation of small molecules. An “electrochemical-FLP” (e-FLP) system will be pioneered by electrochemically oxidising the [BArClH]- products of FLP activation of H2 to produce [BArClH]• intermediates -  a source of “H•”. The activation of small molecules via the e-FLP concept will be explored, and combined with suitab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'COMPARATIVE GENOMICS 2001-2002' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Comparative genomics, once the poor relation of the human genome project, is seen as providing the key to unlock the DNA. According to this strategy model organisms like mouse, rat, Drosophila, zebrafish, yeast and C. elegans) will likely prove to be highly instrumental in identifying human disease genes. Europe has a leading position in the world for research in comparative genomics. In particular the study of some model organisms such as Zebrafish and C elegans was initiated by European Investigators. In more recent years the mouse ENU mutagenesis project way of originate and developed needs at GSF, Neuherberg, Germany and at MRC, Harwell, England. Such a level of excellence needs to be distributed as much as possible between senior and young researchers, thus motivating the need for training courses.The dissemination of this knowledge is quite interesting from a scientific point of view and quite timely for European research in genetics and for the European biotechnology industry. Comparative genomics provides the key to functional analyse genes and their interaction which leads towards a better understanding of data from the Human Genome project. It requires an interdisciplinary and collaborative effort to cope with the needs of the present and future genome based research. Training young researchers in this field makes it necessary to present a broad spectrum of topics. This spectrum covers introduction of model organisms, phenotype, sequence and structure data analysis and includes such diverse areas as expression analysis and proteomics, metabolic and functional networks. A European effort to develop training programmes in the field of genetics requires a strong support for comparative genomics and the availability of training structures where both students and F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular machines based on coiled-coil protein origami' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Proteins are the most versatile and complex smart nanomaterials, forming molecular machines and performing numerous functions from structure building, recognition, catalysis to locomotion. Nature however explored only a tiny fraction of possible protein sequences and structures. Design of proteins with new, in nature unseen shapes and features, offers high rewards for medicine, technology and science. In 2013 my group pioneered the design of a new type of modular coiled-coil protein origami (CCPO) folds. This type of de novo designed proteins are defined by the sequence of coiled-coil (CC) dimer-forming modules that are concatenated by flexible linkers into a single polypeptide chain that self-assembles into a polyhedral cage based on pairwise CC interactions. This is in contrast to naturally evolved proteins where their fold is defined by a compact hydrophobic core. We recently demonstrated the robustness of this strategy by the largest de novo designed single chain protein, construction of tetrahedral, pyramid, trigonal prism and bipyramid cages that self-assemble in vivo.This proposal builds on unique advantages of CCPOs and represents a new frontier of this branch of protein design science. I propose to introduce functional domains into selected positions of CCPO cages, implement new types of building modules that will enable regulated CCPO assembly and disassembly, test new strategies of caging and release of cargo molecules for targeted delivery, design knotted and crosslinked protein cages and introduce toehold displacement for the regulated structural rearrangement of CCPOs required for designed molecular machines, which will be demonstrated on protein nanotweezers. Technology for the positional combinatorial library-based single pot assembly of CCPO genes will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A molecular investigation of Photocatalysis in Zeolites' (ZEO-SIMULATION).

assistant: **Concept**

Photocatalysis using zeolite is a relatively new process for the degradation of pollutants. Zeolites are crystalline structures with a network of interconnected tunnels and cages. The cavities in zeolites confine reactants to a particularly shaped space. Therefore, they act as a selective medium, directing the photochemical reactions to specific products. During photocatalysis zeolites serve either as inert supports for the photocatalitically active semiconductors or as porous adsorbents. In most cases the semiconductor is loaded in the zeolite and the resulting powder is illuminated to become an active catalyst. Photocatalysts adsorbed in zeolites have a higher efficiency than the photocatalyst on its own. This effect has been found for a variety of organic s such as benzene, azo dyes, propizamide, substituted toluenes, phenols, and pyridine that are photooxidised by TiO2. Despite the great interest and the applicability of this type of systems, little is known on the mechanism of catalysis. In this proposa l I put forward a research project aimed at reaching a sound grasp of the molecular aspects of photocatalysis in zeolites by means of a combination of computational methods.The final goal is to develop a molecular mechanism that can explain selective phot ocatalysis with zeolites as shape selective heterogeneous photocatalysts. Only a few of the more than 100 zeolites synthesized are currently used in photocatalysis. A deeper understanding of the underlying mechanisms can be used to evaluate the efficiency of many other zeolites and can lead to cheaper and more efficient photooxidation of pollutants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Activation of Src kinases through dimerization suggests novel therapeutic opportunities' under Horizon 2020.

assistant: **Concept**

c-Src, the first proto-oncogene to be identified, controls many aspects of tumor biology including the capacity of the cancer cells to multiply, survive, and metastasize. We recently discovered that c-Src forms dimers and that dimerization is essential for the activity of the enzyme. This represents a significant paradigm shift in our understanding of the biology of Src family kinases, which until recently were assumed to function as monomeric proteins. The discovery that c-Src functions as a dimer creates the basis for development of a novel class therapeutics in principle based on disruption of Src dimerization. Our preliminary data indicate that such dimerization inhibitors have dramatic anti-tumor activity, suggesting that the proposed research may lead to development of an effective anti-cancer therapy. The project goal is to accomplish the following specific objectives: 1. To determine the efficacy of inhibition of Src myristoylation and dimerization for treatment of cancer; 2. To develop competitive inhibitors of Src dimerization and activity. The project will also create opportunities of boosting the research and innovation capacity of Europe, for obtaining IPRs, commercialization, and setting new collaborations with top US research institutions and companies. The proposal is intended as a career development fellowship that is designed to facilitate my reintegration into the EU science and to further my career towards a leading independent research position. I am confident that the quality and excellence of science produced and the new research and complementary skills obtained during the fellowship will serve as a cornerstone for my future career advancement and mark the beginning of my new laboratory and research program.


**Keywords:** cancer, Src, SFK, tyro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New eco-efficient and healthy professional espresso coffee machine' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This project is the continuation of the funded phase-1 ECOBREW feasibility study that has finished successfully. A previous version of this proposal for phase 2 was submitted in Sept.'15. It was evaluated with a score of 12.81 and awarded with the Seal of Excellence, but not funded due to budgetary restrictions.ECOBREW proposes an innovative healthy and energy-efficient professional espresso coffee machine.Coffee is the second most traded commodity in the world, after crude oil.  40% of the global coffee consumption is out of home, and specialty coffee has become a major worldwide trend.IBERITAL is a 40-year old SME, with 56 employees, an annual turnover of 12 MEUR and 60% in exports, that is targeting the growing market of the Professional Espresso Coffee Machines, a market that is estimated to surpass a volume of 1 billion Euros by 2016.The technology used in coffee machines has not evolved significantly in 100 years. IBERITAL has identified a great opportunity in this growing market for a coffee machine with a completely new design based in the introduction of lead-free materials, energy efficiency and internet connectivity. The proposed innovation aims at new market opportunities addressing 3 global challenges and trends (healthy food, sustainability, connected world) This project and new product fit in IBERITAL's strategic plan, and will result in company growth into a medium sized European Company with a brand that will be globally recognized; with sales doubling by 2019 and tripling by 2022, and creation of employment by tripling staff up to 150 direct and 350 indirect jobs in 6 years.During  phase-2, IBERITAL will perform the final product design and development, and industrial up scaling; certify the machin in EU and seven other countries; demonstrate its perfo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Re-linking suburban youths in Madrid and Paris. The “new localism” and the rol of social and ethnic networks in the integration of youth from immigrant origin' (LOCALYOUTH) under Seventh Framework.

assistant: **Objectives**

In global European cities, youth from immigrant origin who live in disadvantaged areas are disconnected from the networks likely to offer them educational and work opportunities. However, in these poor areas, the negative structural conditions contrast with the capacity of action led by the social networks. We are witnessing the rebirth of localism as a way of condemning the weakening of the Welfare State.There are no comparative studies among North-western and Southern European countries that focus on the principal role played by the civil society in the socialization of youngsters in peripheral neighborhoods. LOCALYOUTH therefore fills a need for comparing the situation of youths between 16 and 29 years in two banlieues of Paris and two barrios of Madrid by taking into account the collective action taken in these environments at a grassroots level. Through an in-depth study of four integration projects of urban and social development a critical evaluation shall be performed on the role played by community networks. An analysis of the importance of the ethnic and gender dimension in the composition of those networks will also be done.The methodology combined case studies, comparative-historical perspective and sociological intervention. Participation observation in associations will be carried out and combined with interviews to people with a long life history in local areas and focus groups with social educators, leaders of associations and policy makers involved in the projects selected for the analysis. In addition, two Sociological Interventions in Madrid and Paris will provide an in-depth knowledge about the situation of the young people and the news dynamics of local participation in two European countries. In summary, LOCALYOUTH offers news keys of analysis to u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Networks in Time and Space' to be submitted under Horizon 2020.

assistant: **Abstract**

This research programme aims to develop a new theoretical framework for modelling and analysing spatio-temporalnetworks. The theory developed in this programme will underpin our ability to exactly specify thestructured form of network behaviour in time and space. This will advance statistical methodology and theory,unifying results from stochastic processes with network theory to do so. New technical approaches to modellingwill be proposed, as well as new asymptotic large sample scenarios. As a consequence of the methodologicaldevelopment, new analysis techniques for applications in real-world problems will be proposed that will improveour ability to make defensible conclusions from real data sets.Modelling network data and estimating such models is challenging, especially in a modern setting, becausemost observed networks are very large. This leads to computational and inferential challenges. However,handling sparse and large networks is not enough to be able to describe highly structured network data. Mostnetworks are coupled with secondary structure, and possess patterned behaviour in time and space. Linkagesbetween nodes are frequently added and removed over time, and implicit structure is generated from latentspatial patterns.The understanding of networks must be extended to encompass spatio-temporal patterns, to quantify suchstructural aspects of network data. This will require combining theory and methods from different parts ofmathematics, and developing new statistical theory. This project therefore aims to a) model temporally evolvingnetworks, b) understand the characteristics of growing and decaying networks, c) model and estimate spatialand temporal characteristics in networks and d) propose new models of spatial structure. These developmentswill combine to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering immune evasion of Acute Myeloid Leukemia' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Acute Myeloid Leukemia (AML) is the most common adult leukemia, with a high frequency of relapse and mortality. After therapy, the persistence of rare leukemia stem cells (LSCs) with disease initiating and therefore stem cell-like properties is a likely cause for relapse. Therefore, novel therapeutic strategies to specifically eradicate LSCs are urgently needed. Natural Killer-cells (NK-cells) are innate immune cells capable of detecting cell surface ligands to trigger a cytotoxic response against diverse tumor cell types. NK-cells are activated either by missing inhibitory or activating ligands, such as known natural killer group 2D receptor ligands (NKG2DL), which become expressed on target cells upon cellular stress or malignant transformation. The groups of Drs. Trumpp, Lengerke and Salih recently described that LSCs evade the recognition from NK-Cells by repressing NKG2DL expression. Importantly, inhibition of Poly [ADP-ribose] polymerase 1 (PARP1) in a subclass of CD34+ AML patient samples reactivated NKG2DL expression and, when combined with allogeneic NK-Cell therapy, eradicated AML in xenotransplantation models. The goal of this proposal is to systematically discover novel NKG2DL regulators in AML to improve immunotherapeutic therapy options for a broad group of AML patients. I have identified monocytic differentiation and DNA hypermethylation as potentially opposing mechanisms of NKG2DL expression. I will combine single-cell transcriptomic and epigenomic interrogation of AML patient samples to discover how NKG2DL are activated during malignant differentiation and how these processes are impeded by DNA hypermethylation. These approaches, together with genome-wide CRISPR-dCas9 gain of function screens, will help identify master regulators of NKG2DL expression. L