RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Antibiotics of the future: are they prone to bacterial resistance?' (FutureAntibiotics).

assistant: **Innovation**

Although several new antibiotic candidates are in the clinical pipeline, the future evolution of resistance in bacteria may render them ineffective. This project aims to develop a framework for forecasting the long-term effectiveness of new antibiotic candidates. For this purpose, we will decipher the general principles shaping bacterial resistance to a wide range of antibiotic candidates currently in development. Using recently developed methods in our laboratory, we will study resistance evolution in bacterial ESKAPE pathogens at unprecedented resolution and address four specific aims. First, we explore the shared features of antibiotics with limited susceptibility to resistance. Second, we systematically map species-specific differences in resistance evolution with implications on narrow-spectrum antibacterial therapies that could remain effective. Third, we assess the clinical risks associated with resistance by studying the global biogeography and habitat-specificity of resistant bacteria. Finally, we systematically explore the potential links between resistance evolution and increased bacterial virulence. The outcomes will provide guidelines for future antibiotic use, aid in genomic surveillance of resistance genes, and facilitate the design of antibiotics with reduced susceptibility to resistance.


**Keywords:** antibiotic resistance, functional metagenomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fighting Crime and TerroRism with an IoT-enabled Autonomous Platform based on an Ecosystem of Advanced IntelligEnce, Operations, and InveStigation Technologies' under Horizon 2020.

assistant: **Concept**

CREST aims to equip LEAs with an advanced prediction, prevention, operation, and investigation platform by leveraging the IoT ecosystem, autonomous systems, and targeted technologies and building upon the concept of multidimensional integration and correlation of heterogeneous multimodal data streams (ranging from online content to IoT-enabled sensors) for a) threat detection and assessment, b) dynamic mission planning and adaptive navigation for improved surveillance based on autonomous systems, c) distributed command and control of law enforcement missions, d) sharing of information and exchange of digital evidence based on blockchain, and e) delivery of pertinent information to different stakeholders in an interactive manner tailored to their needs. CREST will also provide chain-of-custody, and path-to-court for digital evidence. Human factors and societal aspects will also be comprehensively addressed, while information packages for educating the wider public on identifying threats and protecting themselves will be prepared and distributed.The platform development will adopt ethics and privacy by-design principles and will be customisable to the legislation of each member state. CREST will be validated in field tests and demonstrations in three operational uses cases: 1) protection of public figures in motorcades and public spaces, 2) counter terrorism security in crowded areas, and  3) Cross-border fight against organised crime (e.g. firearms trafficking). Extensive training of LEAs' personnel, hands-on experience, joint exercises, and training material, will boost the uptake of CREST tools and technologies. With a Consortium of 8 LEAs from 8 European countries, 7 research/academic institutions, 1 civil organisation, and 7 industry partners, CREST delivers a strong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Overcoming barriers to conversion to organic farming in the european union through markets for conversion products.'.

assistant: **Concept**

The EU currently imports a substantial proportion of organic produce. Converting to organic agriculture is a risky decision for farmers, despite the support payments available. This project seeks to increase the conversion rate through the identification of existing constraints. Furthermore, in keeping with EU policy to encourage market mechanisms for the support of agriculture, the project investigates the potential for growth and development of a niche market for horticulture, dairy and meat products from the second year of conversion. The project takes a food chain approach to the facilitation of conversion by including producer, retailer and consumer surveys. EU policies will be appraised in light of the findings of these surveys. The research findings and policy recommendations will be presented to representatives from the food industry and policy-making bodies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The diversity of Mycobacterium tuberculosis strains in China: tracing the origins of the worldwide dispersion of the multidrug-resistant Beijing genotype' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

In china a large fraction of the population is infected by Mycobacterium tuberculosis with 500.000 new cases every year. The attenuated Mycobacterium bovis Bacillus Calmette Guerin (BCG) is the only available vaccine against TB. However this vaccine does not provide consistent protection against TB. Knowledge of the diversity of the M tuberculosis strains is of major importance to identify M. tuberculosis antigens and epitopes for new protective vaccines and specific diagnostic reagents. Previous work as well as our unpublished study on 70 Chinese M. tuberculosis strains showed that the Beijing genotype is prevalent in China. Strains of a similar genotype are found worldwide (particularly in Eastern Europe and in the countries of the former Soviet Union) and are often associated with multidrug-resistance. The very rapid and efficient dispersion of the Beijing strains suggest that they may have developed selective advantages. We are proposing to organize the analysis of a large collection of strains (3000) from the 31 Provinces of China. The data will be compared to the characteristics of strains collected in other countries. This will produce knowledge on the diversity of Chinese TB strains and show whether the dispersion of the Beijing type is of clonal origin. The present SSA aims at preparing the project in collaboration with Chinese scientists, transfer the technical knowledge, follow the progress of the experiments, collect the data in a shared-database and produce population analyses. The different partners of the consortium will first define the characteristics of the population to be included in the protocol and choose the appropriate methods for genotyping and multidrug-resistance (MDR) assessment. Data on the BCG status, age and gender of the patients as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Immune Monitoring for RIsk STratification in Solid Organ Transplant Recipients' to be submitted under Horizon 2020.

assistant: **Abstract**

Every year ~ 40.000 patients throughout the EU are transplanted a new kidney, lung, liver, heart or another organ. The frequency of clinical complications is relatively high because at present there are no diagnostic tests that help physicians to determine the right dosage of immunosuppressive drugs necessary to avoid both organ rejection and clinical complications caused by infections. Lophius Biosciences GmbH has developed I-Scan, a functional immune monitoring test that within 24 h provides important information on the strength of the immune system in solid organ transplant recipients. I-Scan uses a proprietary cocktail of stimulants that selectively stimulate the clinically relevant immune cells in a patient’s blood sample. The detection of the triggered interferon γ (IFN-γ) release provides a qualitative and quantitative measurement of cell-mediated immune function.The feasibility study performed during Phase 1 will explore issues related to both, the clinical biomarker validation study and the best market entry strategy. Several objectives are pursued in parallel and encompass: • Setting up the business plan which includes a competitor as well as a freedom-to-operate analysis and a market entry strategy.• Selection of clinical study partners  and defining the design of the clinical study, best suited to yield highest clinical evidence• Obtaining regulatory approval for the planned clinical study and setting a strategy to obtain regulatory approval / CE-Marking for final I-Scan products.Lophius will apply for Phase 2 funding of a clinical study to validate that I-Scan improves the outcome of SOT patients. This study is likely to take place in Germany, Switzerland and Austria where Lophius has already established firm links to transplantation centers. The study is t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Light-controlled microenvironment for Advanced organoids with Neural tube and somite Tissues Engineered with Responsive Nanoparticles', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Neural tube (NT) defects, such as spina bifida and encephalocele, affect over 300000 births worldwide each year and originate from alterations in the earliest stages of embryogenesis. Understanding their causes remains challenging because human NT development is inaccessible to direct investigation. To overcome this limitation, LANTERN aims to create a dynamic and shape-controlled reproducible in vitro model of human NT development using hiPSC-derived Neural tube and Somites Advanced Organoids (NSAO). The main objective is to reproduce, with unprecedented precision, the spatial and temporal signals that drive NT patterning, thereby providing a reliable platform to study NT defects.The project integrates complementary innovations: (i) a biomimetic hydrogel niche, engineered from extracellular matrix-like biopolymers and dynamically reshaped through multiphoton microscopy; (ii) nanoparticle-mediated morphogen delivery, exploiting photosensitive gold nanorods to establish adaptive gradients of morphogens; (iii) advanced organoid culture, where NSAO grow under controlled mechanical constraints and are exposed to tunable morphogen sources. Together, these technologies will yield reproducible tissue architecture and accurate dorsal-ventral axis regionalization, validated through advanced imaging and RNA sequencing.By integrating bioengineering, nanotechnology, and stem cell biology, LANTERN goes beyond the state of the art in organoid systems, scaffolds, and morphogen delivery strategies. The outcomes will provide a robust model to identify the molecular and mechanical causes of NT defects, reduce reliance on animal studies, and establish a platform with translational potential for drug screening. Aligned with the MSCA work programme, the fellowship will foster interdisciplin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genetic diversity of cyanobacterial symbionts of lichens and of free-living populations of Nostoc in biological soil crust communities of threatened alvar grasslands' in the context of a Horizon 2020 call.

assistant: **Objectives**

Contemporary nature conservation policy in Europe has identified the protection of alvars and other semi-natural grasslands to be important for halting biodiversity loss. Loss of biodiversity implies not only species and communities but also loss of genetic diversity. To design effective conservation strategies for threatened biodiversity, the basic biology of the target organisms needs to be understood. Lichens are symbiotic entities consisting of at least two components, a fungus (mycobiont) and algae and/or cyanobacteria (photobionts), living in intimate symbiotic association. The genetic diversity of cyanobacteria will be studied in cyanobacterial lichens (cyanolichens) and in free-living cyanobacteria that form biological soil crusts (BSC) in North European alvars. The main DNA markers used will be tRNALeu (UAA) intron and 16S sequences for cyanobacteria and ITS sequences for lichen mycobionts. Cyanobiont specificity of lichen mycobionts and possible overlap in the cyanobiont spectra of different lichens will be determined. Also free-living Nostoc genotypes from the same habitats will be screened in order to establish their potential role in the symbiont pool. The diversity of lichen cyanobionts and free-living cyanobacteria in alvars, restored alvars and alvar-like substitution habitats will be compared to determine the effects of disturbance history on genotype diversity patterns. This study targets the very poorly known relationships between lichen-symbiotic cyanobacteria and their free-living relatives and will be the first of its kind in any grassland environment. The results will significantly improve our understanding of lichen biology and community ecology, and especially of the role of symbiont specificity in generating and maintaining lichen diversity. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Preservations and unification of new and existing Braille Music digital sources for a new access methodology'.

assistant: **Concept**

ObjectivesThe development of an interactive music system for non-sighted people, using the rich and varied digital music heritage existing in Braille, in order to:offer them a wider accessibility and ensure availability for the future;provide interactivity and new creative possibilities; produce instruments able to recognize such digital ASCII formats, to interpret, contextualize and conceptualize them in the structured format. preserve and make homogeneous the Braille music heritage existing in different digital formats . Description of workStart a research that aims at designing an accessible and interactive music storage system, to offer non-sighted user the chance to read an interpreted music structure at different levels thanks to different information such sound and  tactile.Develop a ¿compiler¿ that permits  to contextualize and organize, into defined structures, music Braille existing in different formats in national libraries. Producing tools that enable non-sighted people to explore the score structure at various levels; interact with the music by receiving selected informations thanks to defined commands such as knowing parts, voices, phrasing, etc.Achieving a common format for music data storage in Braille format based on new XML technologies taking advantage of  institutes and standardization bodies (e.g., Mpeg7, CEN, IEEE.)milestoneThe final objectives of this project are:- encouraging the renewal of traditional Braille music libraries to convert their collections, from a simple Braille digital text into an interactive code able to save the original version and to allow a much more articulate representation;- promoting new interactive experiences for non-sighted users useful for study, learning, creative experiences. The results of the project  will be the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Total Energy System: innovative in-farm cogeneration plant for manure valorisation viable even for small farms' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Manure treatment deriving from poultry farms is a continuously increasing problem. Poultry farms are characterized by a lack of proportion between bred animals and farmed area. This imbalance is intensified in farms where there is no agricultural land as in such cases large amounts of manure are generated respect to farmland intended to receive it resulting in intolerable soil and aquifer pollution levels. Manure collection is costly for farmers and it does not solve the problem definitively. On the other side, farms are energy-intensive and main expenses relate to the consumption of electricity and heat. Using poultry manure to reduce or eliminate such cost, could represent an interesting solution that would become vital in order to maintain farms competitive.Today existing manure valorisation systems based on biomass combustion are not a viable solution for farms with low number of animals - for economical reasons.La Coro through the last years developed an innovative solution for this problem. The main objective of the project is the realisation of a pilot plant and market introduction of a highly efficient and flexible  biomass cogeneration system that is able to transform poultry manure (but also other manure and biomass types) in thermal and electric energy (“total energy system”), with the particularity of being usable also  in small farms.The innovative solution will recover and valorise manure through gasification and electricity production, avoid disposal and soil contamination problems, substitute today used fossil fuels thus achieving important benefits for farmers not only in terms of economic savings but also in environmental terms of CO2 reduction. The economic saving on the long run will increase their competitiveness.In short: waste reuse plus cost redu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'BIOFILMS IN BIOREACTORS FOR ADVANCED NITROGEN REMOVAL FROM WASTEWATER' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

For both economic and environmental reasons, maximal use of resources present in wastewater is becoming a very important issue. From this perspective, wastewater is not seen as waste that must be disposed off, but as resource that should be utilized. For energy recovery, anaerobic wastewater treatment is an ideal option, but further research and further developments on the application of combined systems for organics and nitrogen removal under low to moderate temperature conditions are deemed necessary to overcome challenges on extensive applications. The temperature aspect is most important, because even in moderate regions such as Central Europe, the average temperature of wastewater is not higher than 15 °C and e.g. in Scandinavia can be even much lower. Under such conditions, heating of the entire wastewater stream to temperatures favorable for anaerobic digestions and/or e.g. Anaerobic Ammonia Oxidation (ANAMMOX) process (around 30°C) is economically impossible.Within the proposed project, the researcher will investigate the feasibility of combined anaerobic-aerobic treatment of municipal wastewater, specifically 1) at the temperature of municipal wastewater (<15 °C) and 2) using biofilm bioreactors for nitrogen removal to obtain robust and stabile biotechnology. The research fellow will apply number of novel and advanced techniques (MRI, NMR, FISH, microelectrodes) to elucidate mass transport phenomena in biofilms carrying out nitrogen removal from wastewater. As shown in literature, transport of nitrogen species and oxygen in the biofilm is the key phenomenon for control of the nitritation/denitritation process.The output of this project is expected to improve ecological and economical aspects of municipal wastewater treatment in Europe, leading to less energy de