RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Colloids with complex interactions: from model atoms to colloidal recognition and bio-inspired self assembly' to be submitted under Seventh Framework.

assistant: **Abstract**

Self-assembly is the key construction principle that nature uses so successfully to fabricate its molecular machinery and highly elaborate structures. In this project we will follow nature’s strategies and make a concerted experimental and theoretical effort to study, understand and control self-assembly for a new generation of colloidal building blocks. Starting point will be recent advances in colloid synthesis strategies that have led to a spectacular array of colloids of different shapes, compositions, patterns and functionalities. These allow us to investigate the influence of anisotropy in shape and interactions on aggregation and self-assembly in colloidal suspensions and mixtures. Using responsive particles we will implement colloidal lock-and-key mechanisms and then assemble a library of “colloidal molecules” with well-defined and externally tunable binding sites using microfluidics-based and externally controlled fabrication and sorting principles. We will use them to explore the equilibrium phase behavior of particle systems interacting through a finite number of binding sites. In parallel, we will exploit them and investigate colloid self-assembly into well-defined nanostructures. Here we aim at achieving much more refined control than currently possible by implementing a protein-inspired approach to controlled self-assembly. We combine molecule-like colloidal building blocks that possess directional interactions and externally triggerable specific recognition sites with directed self-assembly where external fields not only facilitate assembly, but also allow fabricating novel structures. We will use the tunable combination of different contributions to the interaction potential between the colloidal building blocks and the ability to create chirality in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of Viral Cofactors in AIDS', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The main objectives of this project are the elucidation of the role played by specific viral cofactors in AIDS and the identification of cofactor-targeted therapeutic approaches that could delay or prevent the progression of the immunodeficiency which is characteristic of AIDS.Despite the intensive research efforts made during the last decade, our understanding of the pathogenetic mechanisms of the immune defects associated with full-blown AIDS is still limited. This limitation has significantly hindered the development of effective measures for the prevention and control of this disease. Although it has been hypothesized that viral cofactors may play an essential role in the disease progression toward AIDS, no definitive proof has been hitherto provided. Several lines of clinical and experimental evidence suggest that three recently discovered human herpesviruses, namely, human herpesvirus HHV-6, HHV-7 and HHV-8, may significantly influence the natural history of AIDS and/or some AIDS-related disorders. Understanding the role played by viral cofactors in AIDS may have critical implications both for the prophylaxis and for the therapy of AIDS.The specific objectives of the project are the following:a) To define the role played by HHV-6, a T-lymphotropic and cytopathic virus which synergizes with HIV in vitro, in the pathogenesis of the immunological defects leading to AIDS.b) To define the role played by HHV-7, a natural antagonist of HIV in vitro, in the course of HIV infection.c) To assess the prevalence and replication of a novel herpesvirus (KSHV or HHV-8) in the course of HIV infection. To develop systems for the isolation  of KSHV in vitro (the virus has never been selectively isolated in cell culture) and the study of its biological, immunological and genetic cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Island TIME-LINES to quantify biodiversity change' (TIME-LINES) under Horizon Europe.

assistant: **Objectives**

One of the most exciting and important research questions in ecology and palaeoecology is how fast, where, and why biodiversity is changing; heated debate on the topic within the scientific community reflects observations of apparently heterogeneous rates of change across the world. Biodiversity responses to different types of drivers of change remain underexplored, because to study these phenomena over the necessary span of years (often centuries to millennia) patterns and processes must be inferred from fossil records. There is also evidence that geographical attributes may mediate biodiversity responses to drivers of change, creating further complexity. That biodiversity change is spatially structured is the main hypothesis of TIME-LINES, which will examine ~5000 years of plant biodiversity change and the drivers of that change using a range of high-quality palaeoecological records derived from sedimentary sequences from islands worldwide. Islands are often described as hotspots of biodiversity and natural laboratories with legacies of relatively recent human impacts. For the first time, it is feasible to build palaeoecological networks at biogeographical scales. TIME-LINES will first establish the historical ranges of variability for both drivers of change and biodiversity. Aligning information on the magnitude of biodiversity change with the geographic properties of islands can then address whether change both at taxonomic and functional levels, is mediated by geographical context. The results will open new research horizons, bringing palaeoecology and biogeography together, and developing methods to quantify the effects of drivers of change—not only for islands but elsewhere, and in much greater depth than has been possible to date. From these findings, we can add
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The determination of hydrocarbons in water' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The principal objective of this project was to develop a new on-line measurement system based on infrared attenuated total reflection (ATR) using a polymer-coated sapphire rod for direct quantification of the total hydrocarbon index in water employing the C-H stretching vibration. The sensor was evaluated via laboratory and industrial trials and was developed to a pre-competitive technical prototype stage.An on-line hydrocarbons in water measurement prototype system was developed. The LOD at present for the laboratory prototype, is 5ppb for Undecane with a PDMS sensing layer. The detection limit for the smaller hydrocarbons is in the region of 10ppm. The prototype system has achieved similar sensitivities. This is sufficient for an alarm level indicator for river water intake.The ability to measure a wide range of hydrocarbons was shown for the range of aliphatic hydrocarbons from C5 to C20. A prototype system was developed and tested on site at a water treatment works by an industrial partner. The performance to date has shown good reliability with no erroneous readings and compares favourably with existing commercial monitors.BackgroundHydrocarbons can enter surface water by anthropogenic means from industrial discharges and by spillages. In the case of heavier accidents hydrocarbons may even enter groundwater and as a result pose a threat to human health. In recent years the standard procedure for the determination of hydrocarbons in water included extraction using perhalogenated solvents and subsequent IR spectrometry. However, these solvents have been shown to be hazardous to the environment and must be removed from future use due to EU legislation. Also laboratory analysis by its nature is time consuming, expensive and the inherent time delay means that environmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Regulation of RNA polymerase III transcription by Id proteins and E47'.

assistant: **Innovation**

The Id (Inhibitor of differentiation) family consists of four related transcription factors that are expressed at high levels in rapidly proliferating cells, including those found tumour cells. Overexpression of Id proteins in transgenic mice causes cancers. Ids have been shown to inhibit differentiation and promote cell proliferation in a variety of systems. This is achieved through interactions with other transcription factors such as MyoD, E47 and Ets. To date, all of the published targets of Id regulation are genes encoding protein. However we have discovered that Ids can also stimulate expression of short non-coding RNAs that are transcribed by RNA polymerase (pol) III, such as tRNA and 5S rRNA. This regulation appears to be direct, as endogenous Id proteins can be crosslinked in vivo to pol III transcribed genes. We also detect E47, a protein that promotes differentiation of several cell types, at these genes and find that it represses pol III transcription. This is consistent with the established antagonism between Id proteins and E47. It is well documented that pol III transcripts are overexpressed in many tumours. Our data suggests that, direct activation by Id proteins may contribute to this. It may be important, because elevated tRNA expression was recently shown to have proliferative and oncogenic effects in cell culture and in mice.This proposal aims to dissect molecular mechanisms responsible for Id mediated activation of tRNA and other pol III transcribed genes. We will also investigate the functional significance of pol III-Id interaction. RNAi will be used to test the hypothesis that Id proteins stimulate and E47 antagonises the proliferative and transforming effects of tRNA synthesis by pol III. Furthermore we will test if raising pol III transcription
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The analysis of mitochondrial dynamics in ageing and neurodegeneration' (DYNAMITO), addressing dissemination and exploitation.

assistant: **Impact**

The survival of our most active tissues, such as the brain and heart, throughout decades of a human lifespan presents an extraordinary biological challenge. Mitochondria are central to the life and death of these tissues. They provide the cellular energy required by these cells and protect them by buffering potentially lethal levels of cytoplasmic calcium, while at the same time mitochondria produce much of the molecules that cause cellular damage and contain a lethal arsenal of apoptotic cell death machinery. These organelles require exquisite maintenance processes to keep them intact and prevent potentially catastrophic disruption. Failure in mitochondrial homeostasis is strongly linked to age-related conditions such as neurodegeneration.This subject has garnered intense interest recently with emergence that two genes linked to Parkinson's disease, PINK1 and parkin, regulate the autophagic degradation of mitochondria (mitophagy). Mitophagy is coordinated with mitochondrial dynamics, processes vital to neuronal health. While recent work has uncovered the basic mechanisms of PINK1/parkin-induced mitophagy, many questions and caveats surround the current knowledge. Most notably, all studies to date have used in vitro approaches and non-physiological manipulations. Thus, we still have a poor understanding of this process in a physiological context.I will principally use the powerful genetic techniques of Drosophila to investigate the influence of mitochondrial dynamics on maintaining normal neuronal function and survival, and its impact on neurodegeneration, in the context of an intact animal system. I will also use molecular, cell biology and biochemical approaches in mammalian cells to complement our in vivo findings and verify their relevance to human biology. These in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flexible Optical Injection Moulding  of optoelectronic devices' (FLOIM), addressing dissemination and exploitation.

assistant: **Impact**

FLOIM will develop an automated process for optical assembly of optoelectronic devices, based on optical quality injection overmoulding. Freeform and microstructured optical surfaces are generated directly on the components through thermoplastic microreplication, using microstructured inserts.   The technology aims to simplify the assembly routes for heterogeneously integrated optoelectronics, with drastic cost reduction, high productivity and improved device performance. Such advantages are demonstrated by three case studies (Datacom transceiver, Optical encoder and OLCD display), showing the flexibility of the processing route and the superior quality of the produced parts.   Two control strategies will be tested for improving the yield: process monitoring/actuation, and functional quality assessment of the produced optoelectronic assembly. The mould cavity will be instrumented to verify the quality of the injected material and monitor the components alignment with respect to the optical features of the mould. On the other hand, the manufacturing path will incorporate an in-line optical and functional quality inspection system, with complete traceability of each produced part. The project will incorporate data-based quality awareness computing, supported by process abstraction, for predictive quality assurance and process adjustment based on cognitive control.   A pilot optical assembly line will incorporate all the advances in the project. Extended pilot test runs will allow to evaluate the robustness, quality and differential advantages of process and products, and quantify the productivity and effectiveness of the control strategies. Economic and eco-efficiency indicators will be evaluated, in terms of operational costs, recycling, material and energy efficiency, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Geographical Islands FlexibiliTy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

GIFT is an innovative project that aims to decarbonise the energy mix of European islands. European islands have to abide by the law of their countries that push toward a greener energy mix to comply with the European and international agreements. GIFT is willing to develop innovative systems to allow islands to integrate vast amount of renewables. In order to reach that goal, the coordinator INEA has built a well-balanced consortium gathering a total of 17 partners of 7 countries, including 1 industrial partner, 9 SMEs, two municipalities, 3 research centres and 2 universities. Through the development of multiple innovative solutions, such as a virtual power system, energy management systems for harbours, factories, homes, better prediction of supply and demand and visualisation of those date through a GIS platform, and innovative storage systems allowing synergy between electrical, heating and transportation networks, GIFT will increase the penetration rate of renewable energy sources into the islands’ grid, reducing their needs for diesel generation and thus decreasing the greenhouse gases emissions directly related to it. During 4 years, the partners will develop and demonstrate the solutions in two lighthouse islands, in Hinnøya, Norway’s largest island and the small island of Procida in Italy and study the replicability of the solution in a Greek and Italian islands at the minimum, respectively Evia and Favignana. The complementarity of these islands in terms of climate, energy mix, population and activities is meant to have solutions adaptable to different situations. To even increase this, the GIFT project has started to build a replication board with associations that already gather 1640 European islands that will be able to study replication for their territor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DYNAMICAL SYSTEMS AND THEIR APPLICATIONS' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main objective of this project is to create fundamental understanding in dynamical systems theory and to apply this theory in formulating and analyzing real world models met especially in Neuroscience, Plasma Physics and Medicine. The specific objectives, tasks and methodology of this proposal are contained in the 5 WPs of the project. In WP1 we want to develop new methods for the center and isochronicity problems for analytic and non-analytic systems, study bifurcations of limit cycles and critical periods, including time-reversible systems with perturbations, and investigate reaction-diffusion and fractional differential equations. In WP2 we deal with the problem of integrability for some differential systems with invariant algebraic curves, classification of cubic systems with a given number of invariant lines,  study global attractors of almost periodic dynamical systems and their topological structure, respectively, Levitan/Bohr almost periodic motions of differential/difference equations. The main objective of WP3 is to study dynamics of some classes of continuous and discontinuous vector fields, preserving, respectively, breaking some symmetries, study of their singularities and closed orbits for classes of piecewise linear vector fields. WP4 deals with Hamiltonian systems in Plasma Physics, twist and non-twist area preserving maps, further studies of a recent model proposed to study some phenomena occurring in the process of plasma’s fusion in Tokamaks, numerical methods, and the study of symmetries of certain kinds of k-cosymplectic Hamiltonians. The last WP tackles mathematical models in Neuroscience and Medicine. Firstly, we study several ODE-based and map-based neuronal models, survey in vivo results with respect to Autism Spectrum Disorder (ASD) and pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthesis of several generations of dendrimers with amidometallocene/ amidometallocenium termini with various topologies and study as spectroscopyand electrochemical sensors' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content We propose to synthesize dendrimers which will be able to specifically recognize anions usign redox sensors located at the termini of the dendrimer branches. This recognition should strongly depend on the core, on the length of the dendritic segment added at each generation and on the number of dendritic generations. In order to investigate this point, several generations of dendrimers will be synthe size, functionnalized with redox centers, and tested for the recognition of the a nions. We should be able to investigate the best dendrimer for each anion in or der to recognize and optimize this process. The recognition of the anion with the dendrimer will be effected using an amido metallocene/amidometallocenium termini using the electrostatic interaction betwe en its cationic oxidized form and the anion in synergy with the supramolecular interaction between the acidic hydrogenation of the amide function and the anion The interaction should be an order of magnitude larger with the cationic metallocenium termini than with neutral metallocene form. This should be probed by monitoring the shift of the NH chemical shift in lH NMR when switching from an 18-electron cationic cobalticenium to the isoelectronic (18 electron) neutral ferrocene. Thus both lH NMR and electrochemical methods will be used in complementarity for anionic recognition, which will enrich the set of possibilities of sensors. The topology, surface, shape and cavities of dendrimers provide the potential for the function of drug transport and delivery to biological targets. To reach this ambitious goal, it is fires importance achieve SPECIFIC MOLECULAR RECOGNITION of molecular fragments and ions by dendrimers Molecular rectifiers, transistors and photodiodes have envisaged, the