RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'GEographically relevant information for moBile users in Protected AReas' (WEBPARK), addressing dissemination and exploitation.

assistant: **Impact**

Imagine you are hiking in the Swiss National Park and wonder if you are entering an area where a delicate habitat should not be disturbed. Or walking through the tidal floor on the northern coast of France, and want to check when the tidal wave will be approaching. Or boating along the maze of canals and small lakes in the Netherlands, and looking for a harbour for the evening. The European project Web Park focuses on providing visitors of protected and recreation areas with location-aware services. These services can enhance the quality of the user experience and facilitate the protection of habitats and natural resources by better informing users on their surroundings.Visitors of protected and recreation areas, such as coastal, rural and mountainous areas, need to have access to the correct and most up-to-date information regarding their location and points of interest around them in order to enhance their experience. At present, these geographic information needs of walkers, sailors, mountaineers, cyclists, and tourists are met through many informal and asynchronous channels of communication. However, the widespread availability of mobile internet devices in the next few years with location capabilities will create an opportunity to meet the information needs of this user group through the provision of location-based services.Objectives:Several personalized value-added Location Based Services (LBS) will be developed within the Web Park framework. They build upon existing information currently delivered to tourists and professional users of recreation and protected areas via CD, kiosk and web. These services will enable users to request information from several databases from their mobile phone or PDA and filtering the information based on location, time and user prof
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multi-potent adult progenitor cells to treat stroke' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Successful therapy for stroke will be achieved using cells that can limit ischemic injury and differentiate into the multiple cell types needed for restoring blood flow and neural circuits, and would be available for therapy 'off the shelf'. As Multipotent Adult Progenitor Cells (MAPCs) differentiate into vascular and neural cells, and reconstitute damaged tissues in vivo, we hypothesize that MAPCs is an ideal allogeneic cell product to treat stroke.  In WP1, WP2 and WP3, we will develop approaches to generate committed vascular cells and neuroprogenitors, and identify key molecular events that guide differentiation. WPs 4-7 will rigorously evaluate the pre-clinical efficacy of allogeneic MAPCs or their progeny in stroke. This will include development of noninvasive imaging techniques to follow the fate of grafted cells and evaluate their impact on CNS function (WP4).  We will compare the efficacy of MAPCs with that of till now 'gold-standard' stem cell populations in stroke, and determine mechanisms underlying observed effects (WP5).  We will examine the immunogenicity of MAPCs and their differentiated progeny in vitro (WP6) and in vivo using mice with a 'human immune system' (WP7).  Studies in WP9 will develop clinical grade culture systems to generate human MAPCs and, if needed, lineage committed progeny. Studies in WP8 will develop a framework in which to develop clinical grade stem cell products in an ethically responsible manner. Specific attention to the management of the project.  The management, exploitation and dissemination of the project will be ensured through WP10. These studies will lay the foundation for clinical trials of MAPCs in stroke in Europe in subsequent years. The highly innovative methods, tools and technologies that will be developed will not
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ENHANCing Human Performance in Complex Socio-Technical SystEms' (ENHANCE), addressing dissemination and exploitation.

assistant: **Impact**

Rapid technological development within the maritime industry has improved efficiency, productivity and safety. However, this advancement is creating increasingly complex socio-technical systems, for which training has left human operators ill-prepared. Over 75% of all maritime accidents are attributed to human error, and smaller crew are handling more complex tasks. If safety is to be maintained or improved, it is vital to equip crew with the skills needed to manage them effectively.ENHANCE specifically investigates these issues for maritime applications by utilizing knowledge sharing between process and maritime industries. We will bring together the expertise of engineers, psychologists, human factors specialists and operators to generate solutions to cope with technological development. The project has two main objectives: a) to better understand the human role in complex socio-technical systems through close collaborations between the academic and non-academic sectors; and b) to develop new training and performance assessment methodologies designed to enhance the human performance.To ensure knowledge transfer, ENHANCE will connect academics and industry through an extensive secondment programme. This will bring together expert academic knowledge of advanced training techniques with the needs of the maritime industry and the best practice of the process industry. We will share knowledge across academia and industry, across sectors and across continents. Ultimately, this research will enable the maritime sector to improve the performance of humans within their complex socio-technical systems. This, in turn, will reduce the frequency and severity of incidents, reducing the negative social, economic and environmental impact of the sector. In addressing the needs of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Crimean Congo Hemorrhagic Fever; Modern Approaches to  Diagnostics, Surveillance, Prevention, Therapy and Preparedness' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Over the last years, large outbreaks of Crimean Congo Hemorrhagic fever virus (CCHFV) in several European countries and neighbouring areas are on the rise. This disease poses a great threat to public health due to its high mortality rate, modes of transmission and geographical distribution. Climate changes and observation of the CCHFV vector in central Europe alarm the European community as we cannot exclude that future outbreaks will take place in non-endemic area of Europe. To date, there is no vaccine available and no selective antiviral drug for the management of the disease. The general knowledge of migration, epidemiology, re-assortment and recombination of the virus is very limited. To fill these gaps, the CCH Fever project proposes to create a multidisciplinary collaborative research environment by bringing together selected competitive advantages such as: operative capacity with appropriate high security research facilities, reference centers and clinical samples from endemic areas and an international network of experienced researchers. This multidisciplinary research consortium will facilitate the progress in several key research areas of the field. This program will mainly focus on (i) developing sensitive and biosafe state-of-art diagnostic tools for CCHFV, (ii) gathering the forces and resources in Europe to build a Biobank of clinical samples, (iii) building a comprehensive database consisting in clinical, laboratory and surveillance data, (iv) taking advantage of unique and state-of art tools to progress towards vaccine candidates and specific antivirals against this bio-threat and (v) disseminating the appropriate knowledge to the health care workers in endemic regions and contributing to capacity building. These achievements will provide tools for loca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Stability of Non-Newtonian jets and implications for the onset of turbulence' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The manner by which fluid flows go from a laminar to a chaotic turbulent state is striking, and has significant biological, environmental and technological implications. As a result, a great deal of research effort has focused not only on studying transition to turbulence, but also on predicting and controlling its onset. To date, most of the advanced techniques for transition research have focused primarily on the ``pathways to turbulence"" in Newtonian, or simple, fluids. These efforts, however, exclude a major class of flows, namely complex and non-Newtonian fluids, which are at the core of the pharmaceutical industry, oil and gas, and plastic and paper-making processes. The proposed research addresses this gap: a framework for the simulations of the linear and non-linear stages of instability in two-fluid, non-Newtonian flows will be established, and will be used to characterise and control transition in two-phase non-Newtonian jets, a flow configuration ubiquitous in the above technologies. The subject of the fellowship is innovative as the dynamics of non-Newtonian jets are less explored relative to their Newtonian counterpart. The latter have been the subject of recent advances in stability and direct simulation techniques, some of which were developed by the applicant. These recently developed methods are key to the design, optimisation and control of non-Newtonian flows which have numerous industrial and commercial applications. Furthermore, predictive capabilities and design tools for other transitional flows will improve, since the study of stability of non-Newtonian jets can be translated to a host of other shear flows. The fellowship will translate the candidate's expertise in advanced instability methods from Newtonian to non-Newtonian flows, will further
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MOLECULAR REGULATION OF OSTEOBLAST MOTILITY AND THE BONE-VASCULAR NICHE' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Bone is a dynamic tissue that is constantly remodelled by the coupled activities of matrix-producing osteoblasts (OBs) and matrix-resorbing osteoclasts (OCs). Uncoupled bone remodelling may lead to low bone mass, causing osteoporosis and ultimately fractures, which constitute an increasing medical- and socio-economic problem. During fracture repair, a functional relationship exists between migrating OBs and the invading vasculature. To better understand physiological and disturbed bone remodelling, bone repair, and the communication between bone and vessels, it is crucially important to investigate molecular mechanisms regulating OB function, OB motility, and the bone-vascular niche. Resulting insights can then be used to improve the current cure of osteoporosis and fracture repair. Preliminary data revealed that the homeodomain protein Tg-interacting factor (Tgif) is an important regulator of OB function. Tgif-deletion in mice causes a low bone mass with spontaneous fractures, a disturbed bone marrow vascular network, and a compromised fracture healing with a reduced OB migration. Furthermore, Tgif-deficiency reduces the expression of the angiogenic factor Vegf-A by OBs and Tgif physically interacts with the cell motility regulator focal adhesion kinase (FAK), suggesting molecular mechanisms for the role of Tgif in vivo. Thus, the objectives of this proposal are to analyze the function of Tgif (i) in OB motility and FAK signalling, and (ii) in the regulation of Vegf-A expression and the bone-vascular niche. Both objectives will be accomplished using a state-of-the-art genetic approach in mice for the targeted deletion of Tgif in OBs and a complete set of complementary in vitro assays. Taken together, this project will establish Tgif as a novel physiological regulator o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unravelling early chelicerate evolution and the origin of the sea spiders combining high quality paleontological and genomic data' in the context of a Horizon 2020 call.

assistant: **Objectives**

Arthropoda (e.g. insects, crustaceans, spiders and centipedes) comprises the majority of animal biodiversity and includes model organisms like the fruitfly Drosophila melanogaster.  A rich fossil record, abundant genomic information, high morphological disparity, and unparallelled diversity, have  made arthropods a key model system for macroevolution. Yet, our understanding of arthropod evolution remains incomplete. In part, this is because alternative interpretations of their morphology support different evolutionary hypotheses. For example, the phylogeny of total-group Chelicerata (i.e. the living chelicerates – e.g. sea spiders, horseshoe crabs, spiders and scorpions – and all fossils more closely related to these than to any other arthropod) depends on alternative interpretations for the origin of the chelicerae. These pincer-like first head appendages are found in all living chelicerates, but it is unclear whether they are primitive, derived, or converging characters. Central to this debate are the sea spiders (Pycnogonida), a poorly-understood, marine, chelicerae-bearing lineage, dissimilar in many respects to other chelicerates. It has been suggested that pycnogonids might not be chelicerates and that chelicerae might be convergent or a primitive trait for Arthropoda, which would necessitate a reassessment of early arthropod evolution. Here, I will use a cutting edge computed tomography approach to provide the first detailed study of fossil pycnogonid morphology, and to generate a new morphological dataset spanning all key arthropod taxa. Bayesian and Maximum Likelihood-based total evidence approaches will then be used to combine the new morphological dataset with genomic data and test hypotheses of (1) chelicerate and arthropod relationships, (2) the evolution o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Ce based instrument using microsystem and biosensor technologies for bioremediation monitoring applications'.

assistant: **Concept**

Problems to be solvedThroughout Europe bioremediation is being utilised to remediate sites that have been contaminated with hazardous waste. The toxic pollutants at these sites may consist of metallic elements, organic chemicals, petrochemicals, pesticides, biologically hazardous waste and other hazardous materials associated with the disposal of industrial by-products and domestic waste. These areas pose health risks by resultant contamination of the land and ultimately water reserves.Sampling and analysis of soil, groundwater and leach ate is an essential part of the risk assessment process, in the evaluation of polluted sites as well as in the ongoing tracking of a remediation programme at a landfill site.Scientific objectives and approachThe aim of this work is the development of a cost effective, rapid, portable analysis system for the measurement of bio available toxic metal or organic contaminants, which may be present at natural attenuation landfill sites requiring remediation. The proposed system is intended to be used as a tool in the monitoring or characterisation of a site by discrete measurement. A portable system will be developed, comprising a miniaturised extraction and separation device employing capillary electrophoresis, detectors for specific analyses (metals or organics) by biosensors or immuno sensors and dedicated instrumentation to process the signals generated. Development of extraction procedures for the analysis of plant material will also be part of the project, to be used when phytoremediation is employed as part of the site remediation process. Biosensors to detect toxic metal will use bio-engineered proteins to interact with bio available metals on an electrode surface. The conformational change in the engineered protein will allow a speci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Animated 3D digital reconstructions of early European birds: a new window on the origin of avian flight using “state-of-the-art” techniques on exceptional fossils' to be submitted under Seventh Framework.

assistant: **Abstract**

The origin of avian flight is possibly the most spectacular example of an evolutionary transition and, consequently, has aroused passionate scientific debate and fired public attention. The fossil record indicates that birds emerged within theropods (a group of carnivorous dinosaurs that includes species such as Tyrannosaurus rex) in the Late Jurassic. Mesozoic birds are extremely rare. Their fossil remains are mostly known from exceptional sites such as that of Las Hoyas, in Spain. Four beautifully preserved bird specimens (one of them unpublished), representing at least three species, have been found at Las Hoyas. They are intermediate forms between the primeval bird Archaeopteryx and modern birds both in age and evolutionary stage. The recent advances in X-ray imaging technologies and computer modelling, together with the discoveries of these key specimens, make it possible to use digital reconstructions to study the origin and evolution of flight from a biomechanical perspective. This project aims at using various ""state-of-the-art"" techniques to re-create digitally these early birds so as to study their preservation, chemistry, locomotion, and flight abilities. The fossil birds from Las Hoyas will be digitally brought back to life thanks to the prodigious possibilities offered by synchrotron imaging (both tomographic and chemical). The 3D musculoskeletal models will be animated according to the limitations dictated by their reconstructed anatomy, so that their flying performance can then be evaluated. The synchrotron-based imaging will also provide data to aid in the reconstruction of plumage patterns of the Las Hoyas birds. This ambitious project will bring together ""state-of-the-art"", interdisciplinary science to elucidate and resurrect the biology and locomo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Statistical physics of dense particle systems in the absence of thermal fluctuations' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Frontier research in statistical mechanics and soft condensed matter focuses on systems of ever-increasing complexity. Among these are systems where microscopic dynamics are not controlled by thermal fluctuations, either because the sources of the fluctuations have not a thermal origin, or because “microscopic” sources of fluctuations are altogether absent. Practical applications comprise everyday products such as paints or foodstuff which are soft solids composed of dense suspensions of particles that are too large for thermal fluctuations to play any role. Non-Brownian “active” matter, obtained when particles internally produce motion, represents another growing field with applications in biophysics and soft matter. Because these systems all evolve far from equilibrium, there exists no general framework to tackle these problems theoretically from a fundamental perspective. I will develop a radically new approach to lay the foundations of a detailed theoretical understanding of the physics of a broad but coherent class of materials evolving far from equilibrium. To go beyond phenomenology, I will carry theoretical research to elucidate the physics of particle systems that are simultaneously Dense, Disordered, Driven and Dissipative—D4PARTICLES. By combining numerical analysis of model systems to fully microscopic statistical mechanics analysis, my overall aim is to discover the general principles governing the physics of athermal particle systems far from equilibrium and to reach a complete theoretical understanding and obtain predictive tools regarding the phase behavior, structure and dynamics of D4PARTICLES. Reaching a new level of theoretical understanding of a broad range of materials will impact fundamental research by opening up statistical physics to a whole ne