RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Polyphenols and Gut Microbiota interaction in Cardiovascular Health' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cardiovascular disease (CVD) is the main cause of mortality in Europe with an annual estimated cost of €210 billion. Different European Public Health strategies have targeted diet to prevent/treat CVDs. This multidisciplinary and multi-institutional project aims to provide new insights into the role of the gut microbiota as a key player in the beneficial effects against CVDs associated with the consumption of Polyphenols (PPs)-rich foods. PolyBiota will be developed through innovative research at one of the epicenters of PPs research (CEBAS-CSIC) and secondment at FISABIO (Valencia, Spain). Epidemiological, clinical, and preclinical studies suggest that the consumption of PPs-containing food protects against CVDs (i.e, modulating angiogenesis in atherosclerotic plaques) . However, these benefits are not always observed due to the high inter-individual variability. The gut microbiota has emerged as an essential player that regulates the bioactivity of PPs. Recent clinical trials indicate that the gut microbiota composition play a critical role in the activity of PPs improving CV biomarkers. These studies open a new door to investigate how the interaction PPs-gut microbiota can modulate mechanisms associated with the improvement of CVDs. PolyBiota will investigate: i) role of the gut microbiota as mediator of the effects of the consumption of Ellagitannins (ETs)-/urolithin (Uro)-A- and Isoflavones (IsoFlv)-/equol-enriched diets on angiogenesis/mechanisms related in untreated and antibiotic-treated animals, ii) the “prebiotic-like effect” of the ETs, Uro-A, IsoFlv and equol consumption on the gut microbiota population, iii) the effects of the gut microbiota-biosynthesized messenguers or the ETs- and IsoFlv-derived metabolites on in vitro tubulogenesis. PolyBiota shows an i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Berliner elektronenspeicherring-gesellschaft fur synchrotron mbh (BESSY GMBH)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Description:BESSY II is Europe's most modern research facility to produce synchrotron radiation (sr) in the vacuum ultraviolet to soft X-ray region (XUV region, photon energies ca. 10 eV to 20 keV) for research and development (R&D). Intensities and source brilliance are several orders of magnitude higher than from any conventional source. The 1.7 GeV electron storage ring facility is the European XUV radiation standard. Currently, over 30 beam lines are available for external research. More than 15 are unique insertion device (ID) beam lines with outstanding performances. World record resolving powers have been achieved (e.g. E/-E = 112,000 at 64 eV on UE56/2-PGM2). On selected beam lines the polarization of radiation can be changed from circular to linear with some free choice of angular orientation of the electromagnetic field vector.More beam lines are under construction, which will extend the spectral range more into the x-ray region and will allow an arbitrary selection of polarization. R&D projects range from fundamental physics and chemistry, surface sciences to magnetism, structural biology, x-ray microscopy, new technologies and applications of synchrotron radiation, such as x-ray lithography and micro-engineering. With this contract BESSY encourages and trains EU scientists from research institutions and small and medium-size enterprises (SMEs), -in particular, new users and those from countries without national sr facilities,- to carry out research with synchrotron radiation. To this end BESSY offers full on-site technical and scientific support and can also provide complete experimental stations, e.g. for (angular-resolved) photoelectron spectroscopies, spectro-microscopy, microscopic imaging, x-ray fluorescence spectroscopies and hybrid techniques. If poss
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Capillary Lock Actuator: A novel bistable microfluidic actuator for cost-effective high-density actuator arrays suitable for large-scale graphical tactile displays' (CaLA), addressing dissemination and exploitation.

assistant: **Impact**

According to the World Health Organization more than 285 million people worldwide are visually impaired. In a world where graphics and online content (images, webpages) become increasingly important the inability to perceive information visually is the primary inhibitor for inclusion. In contrast to display technology for sighted people, tactile displays which translate text and graphics to touchable pixels (taxels) have seen little progress in recent decades. So-called Braille lines which display only a single line of text are still the norm. The reason why graphical tactile displays do not exist is the lack of a suitable actuator technology which allows generating massively parallelized individually addressable cost-effective taxel arrays.This ERC Consolidator project aims at a revolution in microactuator array technology with a fundamentally new concept termed the Capillary Lock Actuator (CaLA). CaLA is a novel bistable massively parallelizable microfluidic microactuator which overcomes many of the limitations currently associated with microactuators. It can be operated with low-voltage control signals and requires virtually no power for actuation. CaLA harnesses three concepts inherent to microfluidics: positive capillary pressure, segmented flow and controllable locally confined changes in wetting. The project will use CaLA actuator arrays for setting up the very first portable tactile graphic display with 30.000 individually addressable taxels thereby significantly outperforming the state-of-the-art. It will be based on manufacturing techniques for highly complex microstructures in glass invented by my group. CaLA will be a significant breakthrough in actuator technology and enabling for many applications in microsystem technology. Most importantly, it will be a s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Cherenkov light for total-body Positron Emission Tomography'.

assistant: **Innovation**

The paradigm shift in medicine from the treatment of acute or advanced disease to very early diagnosis and even prevention in cancer, as well as in personalized treatment, puts more stringent requirements on positron-emission (PET) imaging both in terms of sensitivity as well as specificity. Novel long axial PET scanners with an axial field of view that can be greater than 1m offer a very attractive solution to many of these challenges, in particular if they are combined with the Time-of-flight (TOF) PET technology. The time-of-flight resolution of PET scanners is limited by the timing spread due to delayed scintillation emission. By using prompt Cherenkov photons instead, the coincidence timing resolution can be improved. We propose to prove the feasibility of the above idea by combining a set of our break-through innovation steps, latest advances in photon detection with large area fast photon detectors and in the low-noise fast timing electronics. The PET detector that we would develop in the proposed project would allow for a construction of a PET scanner at a lower cost, better performance and ease of handling, if compared with the state-of-the-art clinical devices. If successful, our technology will represent a major leap in the use of PET for cancer diagnosis, staging, restaging, prodromal detection of neurodegenerative and cardiac diseases as well as treatment guidance and monitoring.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Charting the sea of brain waves: Investigation of cortical traveling waves during speech processing'.

assistant: **Innovation**

Since the beginning of the 20th century, oscillatory patterns have been identified in recordings of human brain activity. Neural oscillation research is a highly active area of investigation, with several competing hypotheses about the role oscillations might play in human cognition. Here we focus on the spatial dimension and look at the emergent topic of oscillations in the form of ‘traveling waves’. These have been detected in different cortical areas, but there is no clear computational role. In the proposed project, I will first develop the waveSCOPE toolbox for the spatiotemporal characterization of propagating events. This open source toolbox (WP1) uses a novel-to-the-research-field algorithm. The algorithm leverages the fact that we can record cortical activity with many sensors (e.g. using MEG or EEG) and arrive at multivariate estimation of phases across recording channels. This allows tracking traveling waves across many frequencies, without the selection of a prior frequency-of-interest. The procedure will be validated in resting state data and compared systematically to other state-of-the-art wave detection algorithms. I then will apply the novel methodology to speech processing data acquired via magnetoencephalography (WP2). During the processing of speech, one typically observes a complex coordinated hierarchy of rhythmic activity. We will investigate whether wave propagation direction is congruent to directions expected by functional anatomic organization and known auditory processing stages. The knowledge and skills gained from this interdisciplinary project, using a new recording modality as well as a new domain of study, will allow me to further develop a competitive scientific career as an independent researcher. In terms of scientific impact, the cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Telehealth-ready AI-powered multi-parametric system for surveillance of COVID-19 and cardio-pulmonary chronic patients' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The COVID-19 outbreak causes world health care systems to crumble under the load. This consortium proposes a Home-use/Point-of-Care device, incorporating improved clinical parameters, providing early detection, and monitoring of COVID-19 patients.This consortium presents a computerized auscultation device – the PyXy – which provides expert-level lung and heart check-up. The PyXy brings breakthrough capabilities in terms of sound and infrasound analysis, body temperature, blood oxygen levels, heart rate and respiratory cycle, all analyzed by artificial intelligence (AI) for accurate diagnostic data. The device recently showed very promising results in relation to managing COVID-19 disease. Using H2020 funds, the consortium plans to introduce the PyXy to the market within 22 months: allowing anyone to perform diagnostic at an accuracy not normally accessible to the medical staff.In this project the consortium will collect COVID-19 patient data and take the PyXy to high volume manufacturing level. The consortium gathers two technology provider SMEs – Sanolla, the developer of the PyXy device, and Medsensio, experts in AI for classification – together with an established player in the medical devices and e-health solutions – Riester. The work will be done in collaboration with four healthcare service providers (Natali, BeneVit, Helgeland and PhilonMed) to ensure the PyXy will be accepted by the market from all possible aspects.We believe that PyXy is capable to substantially reduce the health-economic impact on healthcare and elderly care services by preventing hospitalization in emergent-care situations. In addition, as PyXy can be used by lesser skilled individuals, we believe it will potentially bridge the gap in care settings that face extreme shortage of skilled worker
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ENable LIGHT- and synthetic biology-driven volumetric bioprinting of functional human tissues', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

With its ability to print living cells into shapes that resemble human organs, 3D bioprinting has risen exceptional hopes in the quest to produce lab-made human tissues for biomedical applications. However, today’s bioprinting has no means to actively steer cell behaviour and morphogenesis, leaving yet unfulfilled the potential to fully capture organ functions. Challenging this current perspective, ENLIGHT merges synthetic biology, 3D printing, and photonics to develop a radically new technological concept termed optogenetic volumetric bioprinting. This ultra-fast technique uses visible light tomography to sculpt cells and biomaterials into multi-material, high-resolution, centimetre-scale living tissues within less than a minute. Through synthetic biology-inspired strategies, stem cells gain the ability to sense and respond to light patterns provided by the printer and differentiate into selected cell types, essentially permitting for the first time to 3D print cell functions. ENLIGHT targets two breakthroughs: the development of a volumetric bioprinter capable of optogenetic stimulation to instruct cell fate, and its application to build physiological-scale tissues and organoids that replicate human organ-level functionality. As proof-of-concept ENLIGHT will print vascularized endocrine pancreas models that exhibit native-like function. ENLIGHT will introduce a technology for bioprinting a new generation of reliable user-customizable in vitro models to study human biology and pathology. This is urgently needed to advance drug discovery, personalized medicine and to aid the transition to animal-free biomedical research. These results and the actions of industrial, academic and social science consortium partners, will lay the foundation to build market opportunities, le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spins in two-dimensional materials for tunable magnetic and optoelectronic devices' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In order for modern information technology to continue progressing at a rapid pace we require smaller devices consuming less energy.Magnetic materials provide a promising route for nonvolatile memory devices. However, downscaling them is challenging, and information transfer between devices is hindered by short spin relaxation lengths, making it necessary to convert spin information into charge currents, leading to an increase in power dissipation.The aim of this ERC project is to exploit the properties of two-dimensional (2D) materials to combine highly-efficient magnetic devices with optical communication. Specifically, I propose to seamlessly integrate the unique and highly efficient spin-orbit torques (SOTs) of 2D semimetals with the excellent optical properties of 2D semiconductors.Low-symmetry 2D semimetals present SOT symmetries not seen in conventional devices. These are ideal for the control of perpendicular magnetic anisotropy ferromagnets as used in modern high-density memory devices, with the added advantage of their small size. Due to their reduced dimensionality, 2D semiconductors show strong light-matter interaction, efficient electric control over their optical properties, and low lasing thresholds. When combined, energy-efficient devices can be realized in which nonvolatile magnetic information is optically transported over very large distances.To achieve this goal, I will (1) create externally controlled all-2D SOT devices, (2) realize electric tunability of spins and excitons in 2D semiconductors, (3) demonstrate electrical spin injection in a 2D semiconductor with spin direction controlled using SOTs, and (4) develop externally controlled 2D spin LEDs and spin lasers.This project will pave the way for new generations of information technologies, addr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Building up a brain: understanding how neural stem cell fate and regulation controls nervous tissue architecture'.

assistant: **Innovation**

The brain is an extraordinary complex assembly of neuronal and glial cells that underpins cognitive functions. How adequate numbers of these cells are generated by neural stem cells in embryonic and early postnatal development and how they distribute and interconnect within brain tissue is still debated. In particular, the potentialities of individual neural stem cells, their potential heterogeneity and the mechanisms regulating their function are still poorly characterized in situ; likewise, the clonal architecture of mature brain tissue and its influence on neural circuitry are only partially explored. Deciphering these aspects is essential to link neural circuit development, structure and function, and to understand the aetiology of neurodevelopmental disorders.We have recently established transgenic strategies to simultaneously track the lineage of multiple individual neural stem cells in the intact developing brain and experimentally perturb their development. We will use these approaches in combination with recent large-volume imaging methods for high-throughput analysis of individual neural and glial clones in the mouse cortex. This will allow us to assay neural progenitor potentialities and equivalence, characterize developmental changes occurring in the neurogenic niche, describe the clonal organization of the mature cortex and study its link with neural connectivity. To decipher intrinsic and extrinsic mechanisms regulating neural progenitor activity and understand how they produce appropriate numbers of cells, we will assay the outcome of functional perturbations targeting key steps of neural development, introduced in precursors or in their local environment. These experiments will reveal how neural stem cell output might be regulated by cell interactions an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Speech Prosody in Interaction: The form and function of intonation in human communication' to be submitted under Horizon 2020.

assistant: **Abstract**

Intonation, the modulation of voice pitch, is essential for communication as it conveys information that helps listeners make inferences about the pragmatic intent of the speaker. Despite increased understanding of intonations importance, there is little agreement even about essential aspects of its structure and meaning. This is in large part because research has focused either on the form of intonation, often taking a reductive approach to meaning, or has concentrated on meaning but without full scrutiny of form. Crucially, most research has eschewed the study of intonational variability, seeing it as a problem, rather than a natural facet of speech production that needs to be understood and accounted for. Examining all three aspects in tandem is critical for understanding how intonation is structured and functions in communication: considering meaning in the study of intonational form (i.e. phonetics and phonology) can help delimit intonational categories and uncover the limits of within-category variability; in turn, a robust understanding of form will lead to insights into intonational pragmatics. The present proposal will take exactly this integrative approach, based on the PIs recent research, to examine intonational phenomena attested in English and Greek that have vexed researchers for some time (uptalk, high accents, question tunes). Two varieties per language will be studied, Standard Southern British, Bristol English, Standard Athenian, and Corfiot Greek. Their systematic differences with respect to the phenomena under investigation will allow me to examine cross-linguistic differences, and dialectal variation and its role in communication. The investigation will involve phonetic and pragmatic analysis and modelling, followed by series of behavioural and neu