RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Simulation Enhanced Integrated Systems for Model-based Intelligent Control(s)'.

assistant: **Objectives**

EINSTEIN addresses the scientific and technical challenges related to the optimization of energy efficiency in existing buildings.  This is achieved through the development of a new innovative modular simulation-based building control system. This has the ability to: (i) exploit real-time holistic building simulation (integrated with diverse building systems), (ii) directly enable automated control actions of a building and its surroundings (adaptively) and (iii) provide considerable energy savings to the building (by an optimized algorithm). EINSTEIN will formulate and integrate a number of new control strategies to be used with the simulation-based building control system to provide the building manager with the optimum energy efficiency solutions for their building and its use by its occupants. It will not only eradicate errors between ‘as-built’ and ‘as-designed’ conditions but also include predictive analysis with respect to how the building will perform, taking into account future weather predictions and occupant use. The control strategies will be tested and validated on a number of existing buildings
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Global Platform on EMERGING RISK in the Food and Feed chain'.

assistant: **Innovation**

Strategic objectives 1.To create a sustainable global platform for sharing results, stimulating dissemination and setting the research agenda on emerging food safety risks. 2.To develop a global implementation and harmonisation strategy for evaluation of research and related activities. 3.To identify shortcomings in current food safety systems regarding the identification of emerging risks. 4.To develop a strategic research agenda, and initiate joint research activities. 5.To stimulate global exchange of information and dissemination of emerging food safety issues. Abstract Emerging food safety risks are internationally recognised by governments as a major concern in all food production systems. Substantial resources have been invested in national and regional initiatives (e.g. research, regulation) to improve food safety standards, with the aim of identifying emerging food safety risks and facilitate pro-active intervention (e.g. RASFF, INFOSAN-WHO). However, there is no system in place to support the global coordinated exchange of information. Information about relevant research findings and risk management activities is fragmented, and not internationally disseminated. The novelty and value of GO-GLOBAL is that a global network of researchers and research and programming bodies will be established. Tried and tested methods will be used to identify problems and gaps in knowledge, resulting in generation of outputs invaluable to research managers and interested stakeholders globally. The establishment of a permanent structure will contribute to the development of trust between key players and institutions, needed to create an international forum for exchange of information and opinions on matters pertaining to emerging risk in the food and feed chain. The outputs will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Added Value of Seasonal Climate Forecasts for Integrated Risk Management Decisions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The central objective of SECLI-FIRM is to demonstrate how the use of improved climate forecasts, out to several months ahead, can add practical and economic value to decision-making processes and outcomes, primarily in the energy sector, but also in the water sector. Specifically for the energy sector, SECLI-CLIM will assess the impact on operational planning and portfolio management, such as hedging and asset optimization, thus enabling quantification of the value-add provided by seasonal forecasts which have been calibrated, evaluated and tailored for each specific application. Improvements in management decisions will ultimately lead to an improved supply-demand balance and therefore to a more efficient energy system, particularly with respect to renewable energy, with corresponding benefits for climate change mitigation. A simple, but effective, methodology will be used to assess value added. A control case will only utilise climatological conditions based on historical averaged values – currently the most common approach – while a test case will also consider individually optimised and tailored state-of-the-art probabilistic seasonal forecasts. This will be done for nine case studies for Europe and South America: recent seasons with anomalous/extreme climate conditions leading to problematic and quantifiable impacts for the energy and/or water industry. Crucially for success, the case studies will be co-designed by industrial and research partners.These case studies will provide the basis for developing pilot climate services for a number of specific applications, allowing evaluation of the added value of near real-time information for decision making. Thus SECLI-FIRM will promote research advances in the optimization of seasonal forecasts for specific applications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of Sandwich Materials Fatigue Testing Demonstrator' (SMAFAT).

assistant: **Innovation**

In new industrial products, designers use more and more composite materials in particular sandwich materials. These materials are used in structural applications. However there is a real lack of know-how and equipment to fully evaluate the fatigue behaviour of these materials. The scope of SMAFAT programme is to develop a new methodology and system to characterise fatigue behaviour of composite materials. The future system, issued from this programme, will be aimed at the composite SMEs, Transformers and should offer an attractive set of charcteristics (cost, performance, friendliness in use, etc...)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Lignin-derived carbon fiber flexible supercapacitors' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The current energy-storage devices, containing lithium-ion batteries and supercapacitors (SCs), are typically bulky, too heavy, and rigid, to compete the particular requirements of flexible electronics. Therefore, the development of next generation efficient energy storage devices which is light, flexible, aesthetic diversity, and small units with shape-conformability, and excellent mechanical properties, with high energy and power characteristics becomes highly important. However, compared to conventional SCs, research on flexible fiber supercapacitors FSCs are still in its infancy due to their high cost, low energy density, low capacitance, poor flexibility, safety problems, toxicity and scarcity of some nanomaterials, and poor cycling stability, which continuously force us to search for alternative sustainable and high-performance electrode materials. In this respect, clearer coalitions between the lignin-derived carbon fiber composite (CFC) electrode material properties such as fiber thickness and modulated structure, porosity, functionality, effect of dopant, and electrochemical performance during capacitive studies such as capacitance, solid electrolyte interface, columbic efficiency, energy density, cyclability are needed. Notably, we sought to introduce new biodegradable gel electrolytes with high ionic conductivity, pore structures, modulated thickness, will prepare by a facile, green, nontoxic, and cost effective. Throughout the project, we will correlate the physical properties of carbon fiber composite, with their electrochemical properties by using a combination of synthetic approaches and in depth characterisation techniques including physical, chemical and electrochemical characterisation during capacitive studies. These fundamental insights will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Systematic, palaeoflood and historical data for the improvement of flood risk estimation' in the context of a Fifth Framework call.

assistant: **Objectives**

Problems to be solvedDuring the last few years, Europe has been the scene of several severe floods of immense social impact. A statistical approach to the flood risk problem using gauge record data may lead to considerable losses of property and life. If the reliability of flood risk assessment is to be improved, there is a critical need to specifically extend the record of the instrumental period (systematic period) of extreme floods. This record is usually limited to only a few dozens of years and the largest floods are therefore under-rated in the data. Information on hydrological variability and extreme floods can be completed using either or both palaeo flood hydrology (new and developing branch of hydrology and geomorphology based on geologic indicators) and/or historical information (based on documents and chronicles). Long records of extreme floods are then applied successfully in the risk analysis, together with the more traditional empirical, statistical and deterministic methods to estimate the largest floods. These extreme floods are of most interest to the planners and engineers but rarely feature in the systematic period. This information is especially useful for floodplain management, design of hydraulic structures, flood hazard reduction, management of riparian ecosystems and flood emergency plans (i.e. sustainable floodplain development). The recent catastrophic floods in Europe warn of the critical need for Paleo-hydrologic data on floods over long-time scales. SPHERE aims at developing new scientific frameworks and technical tools integrating multidisciplinary approaches (geologic, historical, hydraulic, statistical and GIS) on extreme flood risk assessment. In particular, a complete catalogue of major past floods will be constructed for an area in Fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Genetic analysis of t lymphocyte activation/apoptosis in autoimmune lymphoproliferative syndrome.' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This study aims to increase our understanding of signals and molecules controlling T cell homeostasis by obtaining a dynamic view of activation and apoptosis in T cells and to use these approaches/results in obtaining and interpreting data from a disease of genetic origin (ALPS patients).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Breathing chlorinated compounds: unravelling the biochemistry underpinning (de)halorespiration, an exciting bacterial metabolism with significant bioremediation potential'.

assistant: **Concept**

Bacterial dehalorespiration is a microbial respiratory process in which halogenated hydrocarbons, from natural or anthropogenic origin, act as terminal electron acceptors. This leads to effective dehalogenation of these compounds, and as such their degradation and detoxification. The bacterial species, their enzymes and other components responsible for this unusual metabolism have only recently been identified. Unlocking the full potential of this process for bioremediation of persistent organohalides, such as polychlorinated biphenyls (PCBs) and tetrachloroethene, requires detailed understanding of the underpinning biochemistry. However, the regulation, mechanism and structure of the reductive dehalogenase (the enzyme responsible for delivering electrons to the halogenated substrates) are poorly understood. This ambitious proposal seeks to study representatives of the distinct reductive dehalogenase classes as well as key elements of the associated regulatory systems. Our group has been at the forefront of studying the biochemistry underpinning transcriptional regulation of dehalorespiration, providing detailed insights in the protein CprK at the atomic level. However, it is now apparent that only a subset of dehalogenases are regulated by CprK homologues with little known about the other regulators. In addition, studies on the reductive dehalogenases have been hampered by the inability to purify sufficient quantities. Using an interdisciplinary, biophysical approach focused around X-ray crystallography, enzymology and molecular biology, combined with novel reductive dehalogenase production methods, we aim to provide a detailed understanding and identification of the structural elements crucial to reductive dehalogenase mechanism and regulation. At the same time, we ai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Mitochondrial Unfolded Protein Response' (UPRmt), addressing dissemination and exploitation.

assistant: **Impact**

Mitochondria—organelles specialized in energy harvesting through oxidative phosphorylation (Oxphos)—critically influence metabolism, health and lifespan. Evolved from endosymbiotic proteobacteria, mitochondria retained the vestige of the bacterial genome, the mitochondrial DNA, which encodes 13 subunits of the Oxphos complexes, while the remaining ~80 Oxphos components and the rest of the mitochondrial proteome are encoded on nuclear DNA, translated in the cytoplasm and imported in the mitochondria. The control of the mitochondrial proteome by two genomes exposes these organelles to proteotoxic stress in case of an imbalance between the nuclear- and mitochondrial-encoded proteins. Upon such stress, several mitochondrial protein quality control (mtPQC) pathways, including the mitochondrial unfolded protein response (UPRmt), will sense, transmit and re-establish mitochondrial proteostasis through mitonuclear regulatory circuits. Although a robust UPRmt circuit improves health and lifespan in C. elegans, much less is known about mtPQC in vertebrates. We propose here to characterize UPRmt pathways across 3 species by: (1) mapping mammalian UPRmt genes and networks in vivo after the induction of the UPRmt in a large murine genetic reference population at 3 different times throughout life with 2 different inducers; (2) integrating these UPRmt networks with a wide set of clinical, mitochondrial, and molecular phenotypes collected throughout life to establish links between UPRmt mechanisms and health- and lifespan; (3) mechanistically validating the most important UPRmt pathways, using loss-of-function studies in cells, worms and mice; and (4) clinically translating promising UPRmt hits, using genetic association studies in human cohorts. The insight gained will mechanistically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'From country level to a pan-European perspective: A co-ordinated approach to controlling cystic echinococcosis'.

assistant: **Objectives**

Cystic echinococcosis (CE) is a major regionally relevant communicable disease in the whole Mediterraneanregion and among migrants to the EU. Its public health importance is growing while surveillance, prevention, and clinical management are still far from satisfactory. In EU member states, CE is an orphan disease, and there is comparatively little experience with treatment. However, health services in EU partner countries are increasingly confronted with the clinical management of CE patients due to migration. This proposal aims at (I) devising an standard methodology for transformer data collection and uniform data presentation in the fields of surveillance, prevention and clinical management of cystic echinococcosis, (ii) identifying effective and feasible prevention measures, (iii) collecting systematically data from endemic (MPC) and non-endemic (EU) countries with respect to clinical management procedures of cystic echinococcosis for the four treatment categories surgery, PAIR, drug treatment, watch & wait, (iv) assessing the clinical management procedures with respect to cure rate, complication rate, recurrence rate, and cost, and (v) making recommendations for improved surveillance, prevention, and case management and quality of care.Forseable benefits of the projects)High-quality, transformer information on transmission and treatment of cystic echinococcosis available in endemic and non-endemic regions)Best practice" prevention recommendations for the MPC region available)"Best practice" treatment guidelines available in all participating countries)Improved quality of clinical management of CE in all participating countries)Transfer of ultrasound-based management techniques from EU to MPC countries)Management experience from endemic MPC countries available in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'POTENTIAL- FIELD RELATIONS AND THEIR EXISTENCE WAVE EQUATIONS,THEIR EIGENVALUES,DETERMINANTS AND QUANTISATION'.

assistant: **Innovation**

Research objectives and content The objective of this project is the study of wave equations and the integrability conditions for Field - Potential relations. Particular issues we intend to address are: (1) The study of eigenvalues, determinants and the resulting spectra of Laplacians, in flat and curved spacetimes, with examples such as the Weyl and Lanczos tensors. We also aim to write various computer programs (SHEEP and Mathematica) to help with the computing of the eigenvalues as well as supplementing the theory. (2) The study of Potential - Field relations and the integrability conditions that accompany them together with possible restrictions of existence when we try to extend the systems to higher dimensions. Particular reference will be made to the existence of instantons and monopoles arising from the potentials and computer simulations of them. (3) The study of the already existing framework for Quantum Gravity using Ashtekar variables and the possible similarities between this and a fully quantised version of the Lanczos and Weyl tensors. Training content (objective, benefit and expected impact) The training content will include the learning of various approaches to quantising arbitrary Potential - Field relations, with particular reference to the Ashtekar formalism. Also a greater knowledge of eigenvalues and spectra of Laplacians with particular reference to the Atiyah-Singer index theorem will be achieved. Links with industry / industrial relevance (22)