RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Computerized Molecular Evaluation of Toxicity', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

We are more and more aware of the need to understand and predict the consequences of the chemicals on the health of human beings and the wild life. Using conventional methods, the assessing of toxic and ecotoxic risks should need funds, time and resources that are not available to solve in detail all the problems related with the increasing number of chemicals. On the other side many data and experiments are available, on thousands of chemicals. Further important information can be obtained from molecular descriptors. Molecular parameters and descriptors have been often used to describe, understand, model and predict the behaviour of chemicals in certain phenomena The explosion of information requires a radical change in the way to deal with the data of information. Artificial intelligence (AI) has been used in a few cases for toxicity prediction and expert systems (ES) in this field have been produced. Today, techniques such as inductive learning algorithms, fuzzy logic, artificial neural networks (ANN) and evolutionary algorithms (EA) can be used to model processes and phenomena with a non-linear behaviour. No studies have been done to compare all the techniques so far introduced using the same set of compounds. This research will focus on the relationship between chemicals and their toxic and ecotoxic effects investigated through updated computerized approaches. The major objective of the COMET is to extract as much as possible information from the already available knowledge, from toxicity and ecotoxicity databases and suitable molecular descriptors, using advanced computer approaches such as fuzzy logic, ANN, EA, inductive leaming lgorithms and AI. This implies two separate objectives. A) Previous studies to predict toxicity used or another toxic activity (correlat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of an effective and safe systemic Myc inhibitor for the treatment of multiple cancer types.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Current cancer therapies target redundant cellular functions often compensated for by cancer cells, resulting in resistance to treatment. Here we propose an innovative approach to inhibit Myc, a non-redundant and “most-wanted” therapeutic target for human cancer. Targeting Myc has long been considered unfeasible because of the potentially catastrophic side effects in normal tissues. Against this dogma, we showed that Myc inhibition by Omomyc, a Myc mutant designed by Dr. Soucek, has a dramatic therapeutic impact in multiple mouse models of cancer, while causing only limited and reversible side effects. Critically, there is no emergence of resistance.  Thanks to the ERC-2013-CoG n° 617473, we discovered the unexpected cell-penetrating properties of the purified Omomyc polypeptide. Moreover, we found that it is anti-tumorigenic after local (intranasal) delivery to mouse models of lung and brain tumors, and could therefore become the first clinically-viable direct Myc inhibitor. With this ERC PoC, we propose to develop a new drug based on an Omomyc variant that enables systemic treatment of several cancer types including lymphoma, breast, and melanoma. In all these cancers Myc contributes to multiple aspects of tumorigenesis including immune suppression. At the end of this project we will have a patent protected therapeutic polypeptide active in vitro and in vivo and ready to enter clinical trials Phase I/II in patients and to continue its commercialization. The forecasted peak revenue for such first-in-class drug in those indications reaches 2.612 M€ annually.  With this ERC PoC project we will achieve essential milestones to develop this innovative therapeutic polypeptide by establishing the feasibility, including a commercial data package  and cost estimations for the i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Foundation Model for Lattice QCD: Learning to Understand the Standard Model and Beyond' (FoundLatt).

assistant: **Innovation**

Despite describing fundamental physics with spectacular accuracy, the Standard Model of particle physics is known to be incomplete. As experimental programmes probe its boundaries at higher energies and with better precision, it is critical that measurements are faced with fully controlled theory predictions. Lattice simulations of Quantum Chromodynamics (QCD) form a major pillar of this effort. However, even with increasing computing capacity, many lattice QCD calculations will not be possible without new techniques.FoundLatt aims to solve this challenge by developing the first machine learning (ML) foundation model for lattice QCD. As exemplified by the highly successful ChatGPT, these large, general-purpose models have recently shown great promise in other contexts. Combining methods from these contexts with specialised ML methods that already accelerate specific lattice QCD tasks, I will create a lattice QCD foundation model that performs multiple challenging tasks over a range of physical parameters. The main innovation of this programme is a ""train once, use forever"" methodology, which will involve a centralised investment of effort that supersedes impractical training of non-reusable models.This objective will be achieved via three complementary work packages (WPs). My team and I will develop and train a foundation model capable of two critical tasks, importance sampling and precise estimation of observables, first for a reduced model of QCD (WP1) and then the full theory of QCD (WP2). We will also develop a method to learn a ""quantum perfect"" action for QCD, then fine-tune the foundation model to accomplish this (WP3). Such an action has zero lattice discretisation artefacts, thereby removing one of the largest sources of systematic uncertainty. The main out
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ADAS for Fusion in Europe', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

ADAS-EU will be a support activity for implementation of atomic data in plasma diagnostics and modelling at fusion laboratories throughout Europe, for management of databases of relevant fundamental and applied data and for promotion of key fundamental atomic data calculation and measurement.  It will enable improved effectiveness of analysis of existing fusion experiments and prepare for ITER. The primary scientific objectives are provision of analysis tools and necessary atomic/molecular data for spectroscopy and broadband radiation detection at all wavelengths in all plasma regions.  Provision of derived atomic/molecular data for plasma models, including passive emission, near surface emitters, beams, beam penetrated plasma, field disturbed atoms and ions, electron distribution functions, fast particles, slowing down particle distributions and beam calibration. All will be in the context of European-wide shared methodologies, databases and maintenance. ADAS-EU will be an extension of the international ADAS (Atomic Data and Analysis Structure) Project, acting for fusion in Europe, but with developments and deliverables benefiting fusion research world-wide. ADAS-EU will be tied to Euratom Associated Laboratories of the European fusion programme.  Also, ITER relevant studies and important issues arising in these laboratories will be identified, developed and validated in partnership. ADAS will continue as a unified system with common code and data assembled, organised, verified and archived centrally.  Modification and advance in atomic physics modelling and data stemming from ADAS-EU will be consolidated centrally in ADAS, reissued to all Euratom Associated Laboratories and released into the public domain.    There will be four lead Euratom Associated Laboratories lin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A software tool for the Bayesian estimation of Heterogeneous Agent macroeconomic policy models' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

My ERC-CoG project has advanced the methodological frontier in solving and estimating macroeconomic equilibrium models, enabling analysis of the interplay between business cycles and inequality. To transform this innovation into a benefit for society, policymakers must be able to work with models with ease. This will allow them to comprehend how the policies they propose impact both the macroeconomy and income/wealth distribution. For this purpose, policymakers require a software tool that allows for swift development and analysis of models. The ERC-CoG-funded research has produced a pilot software that can theoretically achieve this, alongside fundamental methodological research. However, it lacks the versatility and user-friendliness required by policymakers who must develop answers to policy questions under time pressure. The aims of the BASEforHANK project include the further development of the pilot software into a more user-friendly and versatile tool. If successful, this development will enable policymakers worldwide to understand the impacts of their policies better, resulting in more socially cohesive and stable growth. The development follows the model of the Dynare software package, which made it possible to use macroeconomic equilibrium models with representative agents that are now pervasive in policy institutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Embedding and singularity structure of string solitons' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The present research project centres around p-brane solutions of supergravity theories. The first part of the project aims to develop a geometrical description of extended object configurations embedded in an ambient spacetime. This will be achieved by performing a covariant decomposition of the background spacetime into p-brane worldvolume and transverse space. In the second stage of the project, this formalism will be exploiled to address the question of how the dynamics of a supergravity theory determine the possible p-brane configurations. Furthermore, the coupling of p-brane sources to supergravity theories, and the related issue of the singularity structure of p-brane spacetimes, will be clarified by mimicking an ADM construction for p-brane delta-function sources. In a separate study, in collaboration with Profs. Stelle and Sezgin. an algebraic approach to obtain the equations of motion of the p-brane sources themselves will be developed. Training content (objective, benefit and expected impact) The relatively small size of the Theoretical Physics Group will give me ample opportunity to discuss my work with the established researchers of the group and to develop close personal contacts with them. In addition, a series of weekly seminars is dedicated to recent topics in string and supergravity theories and provides an informal way of getting to know the other researchers in the field from nearby universities in London, Oxford and Cambridge. The long-standing involvement of the group in EC science networks reflects its international orientation. Links with industry / industrial relevance (22) The only point of possible industrial relevance in this pan of theoretical physics is to the development of symbolic manipulation software. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Principles of retinal neuronal lamination from zebrafish to humans'.

assistant: **Innovation**

Neuronal lamination is a hallmark of many diverse brain areas where it is important for efficient circuit formation and neuronal wiring. Despite this significance, the cellular and tissue scale principles that ensure successful and robust lamination are not fully understood. In particular, how cell-tissue interactions and biomechanics influence neuronal lamination is only scarcely explored. To fill this gap, we will use the vertebrate retina with its five neuronal cell types arranged in a highly ordered pattern to investigate the emergence of neuronal lamination. We will initially use the zebrafish system and employ long term light sheet imaging to reveal the migration behaviour of the different retinal neurons. Based on this, transcriptomics approaches will enable the dissection of cellular pathways and extracellular cues involved in neuronal migration and overall lamination. To dissect how biomechanics influence lamination, we will use Brillouin microscopy to explore the influence of changing tissue stiffness on lamination and test the role of differential adhesion. These combined results will be the basis to expand studies to the human system and ex vivo human organoids to generate insights into human retinal development.To date, systematic studies investigating molecular pathways in combination with biophysical parameters to understand brain formation across model systems are rare. Due to our previous expertise, we are in an excellent position to perform such interdisciplinary, integrative and interspecies approach. This will unveil common denominators of retinal neuronal lamination in zebrafish, humans and human organoids and thereby reveal the similarities of retinal development in different species and how developmental programs compare in vivo versus ex vivo.In
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MONETARY POLICY, HETEROGENEITY, AND THE HOUSING CHANNEL' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Great Recession has brought to light the importance of housing and household debt for the propagation of shocks in the macroeconomy. For a majority of households, owner-occupied housing represents the single most important asset in the household portfolio and is tied to the single largest liability—the mortgage. The broad objective of this project is to investigate the rich role that housing and nominal mortgage borrowing jointly play in the transmission of monetary policy.  First, monetary policy induced-movements in house prices translate into consumption changes because of wealth effects. Second, a contractionary monetary shock raises the cost of borrowing which reduces the demand and as a result the liquidity of the housing market, further depressing house prices and further increases the cost of borrowing. Furthermore, nominal long-term mortgage debt implies that changes in monetary policy result in redistribution between lenders and borrowers and generate cash-flow effects that are larger for borrowing constrained households. In order to quantify these various mechanisms, we build a heterogenous agent New Keynesian (HANK) model with a frictional housing market and nominal mortgage debt.  The model will be able to match the rich empirical heterogeneity in home ownership, leverage and marginal propensity to consume (MPC) across households. In particular, we aim to match the significant difference in MPC between highly leveraged households and less-leveraged ones that we document in the data.  We will then use the model to answer the following questions:  Is there any asymmetry between contractionary and expansionary monetary policy responses? Does effectiveness of the policy depend on the distribution of mortgage debt? How to manage a liquidity trap induced by a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Lignocellulosic Ethanol Demonstration' (LED) targeting Seventh Framework.

assistant: **Abstract**

The global object of the Lignocellulosic Ethanol Demonstration (LED) project is to design, construct and operate the first biofuel commercial facility in Europe using second generation technology, consisting on a lignocellulosic biomass to ethanol plant. The total lignocellulosic biomass input to the process is 522 dry tonne/day, resulting in an ethanol production of 50 MML/yr. In addition it will produce lignin and distiller biomass. The global strategy of the work plan in order to meet the targets consists of the following items:• Biomass supply plan development. Design of the procurement plan and business model for a non conventional harvesting/transportation concept will be carried out.• Basic design. Based on Abengoa Bioenergy’s know-how and experience after the design and construction of pilot and demo plant of York (Nebraska, US) and Babilafuente (Salamanca, Spain) respectively, and the operational experience in the York pilot facility, the specific basic engineering design for the facility will be developed.• Detailed engineering. Results on basic engineering will be further employed for the detailed engineering of equipment, piping, auxiliary systems, control & instrumentation, structures, supports, electrics and civil works.• Construction. Outputs from the previous phase will be materialized during the construction phase.• Commissioning and start-up. Once the facility construction is over, first proofs will be carried out for checking the smooth operation of each piece of equipment.• Fleet assays. The final ethanol will be tested in vehicles engines for demonstrating both the affinity of bioethanol and its effects in mixtures with petrol.• Research and Development for engineering validation. R&D activities associated with the lignocellulosic biomass to ethanol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ultra-bright nanoscale SEM-on-a-chip' (MONARCH), addressing dissemination and exploitation.

assistant: **Impact**

The technological objective of MONARCH is to produce the world's first scanning electron microscope (SEM) on-a-chip. Such an instrument would represent a step-change in electron beam (e-beam) technology comparable with the introduction of the silicon chip to electronics. This device will be orders of magnitude smaller than existing technology, would operate at lower voltages and have an order of magnitude higher resolution for a fraction of the cost of a current state-of-the-art SEM. It would provide the first instrument capable of rapidly scanning a surface layer and producing an image with elemental identification at atomic resolution.This disruptive technology has dramatic implications for many sectors other than electron microscopy, including e-beam lithography, genetic sequencing, ultra-high density data storage and focussed ion beam milling. In particular it is expected to be a key enabling tool for the booming sectors of nanotechnology and MNEMS (micro-nano-electromechanical systems).