RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Systems biology of nuclear receptors: A nutrigenomics approach to aging-related diseases' in the context of a Sixth Framework call.

assistant: **Objectives**

The aim of this network is to meet two major challenges within the EC. Firstly, to dissect and exploit mechanisms, which relate dietary input to health, and secondly to train scientists in an interdisciplinary and intersectorial fusion of post-genomic arenas. Nutrigenomics aims to dissect mechanisms conjoining dietary factors to physiological function and pathological syndromes, such as cancer and osteoporosis. These and other aging-related syndromes remain poorly understood, but it is agreed that diet impacts both their incidence and prevention.Central to the bodies ability to perceive and respond to dietary signals is the nuclear receptor (NR) super-family of ligand-activated transcription factors, which respond to a range of macro- and micronutrients. Thu s NRs act as nutrient sensors and play a central role in the dietary effects on the genome during aging and disease development. To unite the actions of multiple signalling pathways, NucSys will combine inter-sectorial perspectives of NR biology and apply inter-disciplinary expertise. Critical amongst these will be the application of systems biology (SB) skills to comprehensively model actions. SB has emerged as a key mathematical approach to generate a unified paradigm for predicting the multitude of processes i n a living cell.Key to realizing the originality and pertinence of the research objectives is the flow through" between partners of activities, personnel, reagents and expertise, which in turn is ensured by the delivery of the training objectives. The collected technical expertise in the network ranges from modelling and bio-informatics to creation of inducible gene knockouts in mice and covers the most important areas of modern biosciences. The divergent partner institutions, ranging from universities an d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Theory of nonradiative decay with two or more electrons at play' (2021-2027).

assistant: **Innovation**

UNBOUND TWO aims to develop the quantum chemistry methods that are needed to interpret next-generation spectroscopy involving two or more unbound electrons and to understand chemical reactions involving unbound doubly-excited states. Emerging spectroscopies can probe correlations between two electrons, which is fundamentally impossible with techniques that probe only one electron. To gain information about electronic and molecular structure from such spectra, theoretical modeling is key. However, existing methods are able to deal with only one emitted electron or they are geared toward atoms. As a result, the full potential of spectroscopy is not yet realized for molecules.Electron attachment accompanied by electronic excitation can mediate unique chemical reactions that attachment to the ground state does not support, for example the cleavage of OH bonds. Theoretical modeling is essential to harness such reactions, but existing methods struggle with the pivotal unbound doubly-excited states so that electron-induced chemistry is still at an early stage.Building on recent breakthroughs for nonradiative decay in which only one electron becomes unbound, we will investigate processes in which two or more electrons are at play, for example in Auger and Coster-Kronig cascades and in dissociative electron attachment and dissociative recombination. To achieve these goals, we will advance the quantum chemistry of unbound electrons substantially. We will develop methods that treat singly-excited and doubly-excited states evenhandedly and describe the correlated motion of two emitted electrons. In computational applications, we will study the interaction of organic molecules and transition-metal compounds in gas phase and solution with ionizing radiation and free electrons over an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Actin cytoskeleton and cell signalling'.

assistant: **Objectives**

The actin cytoskeleton plays a central role in many fundamental cell functions such as cell motility (Pollard and Borisy 2003)*, endocytosis (Jeng and Welch 2001), phagocytosis (Castellano and others 2001) and cytokinesis (Pollard and others 1990). The rem odelling of the actin cytoskeleton is controlled by multiple signalling pathways. The in vivo signalling activity of GTP-binding proteins ol the Rho subfamily requires numerous effectors, many of which are involved in regulating the reorganisation of the a ctin cytoskeleton (Bishop and Hall 2000). Recent results provided insights into the structure of one of these effectors, the Arp2/3 complex (Robinson and others 2001; Volkmann and others 2001). Formons, downstream effectors of Rho proteins, have multi-doma in structure involving FH1, FH2, FH3, auto-regulatory and Rho protein binding domains. For the S. cerevisiae formin, Bnilp, it has been shown that a construct of the FH1-FH2 region nucleates unbranched actin filaments in vitro independently of the Arp2/3 c omplex (Pring and others 2003; Pruyne and others 2002; Sagot and others 2002). However, much less is known about the corresponding domains from mammalian formins. To elucidate the molecular mechanisms underlying the function of mDia proteins we will stud} different mammalian formin domains. We have the expression systems (E. Coli) for three mDia FH2 domains. Our first experiments showed that the FH2 domain of mDia3 actually blocked the polymerisation by buiding to the barbed end of actin filaments. This FH2 domain could bind to actin filaments in a 1:1 molar ratio and decreased the critical concentration of actin. To gain further insights we will characterise /'. the effect of formin domains on the actin polymerisation, ii. the interaction of formin domains with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optimising a High Efficacy Plasmodium vivax Malaria Vaccine' in the context of a Horizon Europe call.

assistant: **Objectives**

Plasmodium vivax is the most widespread human malaria with 2.5 billion people living at risk in South America, Oceania and Asia. The revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria, calling for a vaccine intervention to achieve 75% efficacy over two years, now equally weighted with P. falciparum. However, if this ambition is to be realised, new and innovative approaches are urgently required to accelerate next-generation vaccine research and development, whilst the few known candidate antigens need to undergo early-phase clinical assessment.Here, we build on exciting breakthroughs in P. vivax vaccine research, recently pioneered in Europe, including new transgenic parasite technologies for functional assay development and production of a parasite clone that is safe for use in controlled human malaria infection (CHMI) clinical models. The Objectives of OptiViVax will now integrate ambitious multi-disciplinary scientific and clinical approaches around the parasite’s lifecycle and will use our increased knowledge of P. vivax immuno-biology to further develop next-generation vaccines with improved efficacy. We will diversify the portfolio of new antigens ready for clinical testing by reverse vaccinology and diversify their delivery with new platforms and adjuvants developed using sustainable and improved GMP bio-manufacturing know-how. In parallel, the efficacy of known leading antigens will be benchmarked for the first time using innovative design of clinical studies and CHMI models making these lead candidate vaccines ready for future field trials. Improved preclinical functional assays, using state-of-the-art transgenic parasite lines, will also allow for mechanisms of antibody-mediated protection to be deciphered. The avail
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Assessment of the regional impact of droughts in Europe' (ARIDE) targeting Fourth Framework.

assistant: **Abstract**

The demand for European Water Resources has increased from 100 km3 per annum in 1950 to 550 km3 per annum in 1990, with forecasts that this will increase to 660 km3 by the end of this Century (EEA, 1995). Such increase will, undoubtedly, result in future conflict between human demands (commercial, social & political) and ecological needs, most critically in periods of severe and extensive droughts. It is essential that techniques are developed to assess the frequency of droughts in European rivers and how these may change in the 21st Century. The Fight against Water Deficits" has been identified by the Task Force: Environment Water and this will be addressed by ARIDE by carrying out a pan European Study focusing on three key objectives. The first, is to understand the processes which control droughts with special emphasise on rainfall regimes, weather pattern and groundwater regimes. The second, is to develop methods for estimating the spatial distribution of drought statistics on an European scale. The third, is to develop techniques to predict the relative impact of future environmental change including climate variability and land use change. ARIDE will be supported by the UNESCO/FRIEND (Flow Regimes from International Experimental and Network Data) project which includes representatives of UNESCO, WMO, the European Environment Agency and the National IHP committees of European countries. ARIDE will have full access to the European Water Archive - a database of daily flow series and thematic data from 4,000 European rivers which has been established by the FRIEND project. The objectives will be achieved by developing a consistent method for defining and analysing the temporal and spatial characteristics of European droughts. The analysis of regional drought character
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'INNOVATIVE TOOLS FOR SUSTAINABLE EXPLORATION OF MARINE MICROBIOMINNOVATIVE TOOLS FOR SUSTAINABLE EXPLORATION OF MARINE MICROBIOMES: TOWARDS A CIRCULAR BLUE BIOECONOMY AND HEALTHIER MARINE ENVIRONMENTS' (BLUETOOLS) targeting Horizon Europe.

assistant: **Abstract**

Marine microbiomes represent 90% of the total living marine biomass but only a small fraction of them can be cultivated. For this reason, they are an underexplored source of bioactive compounds, carbohydrate polymers and proteins, among others. Sampling the marine biodiversity, screening, identifying and isolating the relevant microbes is cumbersome, expensive and results in a heavy environmental burden, low yields, high costs and long times to market. Therefore, new approaches are necessary to overcome the limitations for the study of marine microbial communities and their “econological use”. BLUETOOLS will unravel the potential of marine microbiomes for healthier oceans and the Blue Bioeconomy through integration of different fields to develop cutting-edge tools that support fast, efficient AND sustainable exploration and exploitation of microbiomes, avoiding the drawbacks of conventional biodiscovery practices. The expected results of BLUETOOLS include discovering several hundreds of enzymes, rhodopsins, resistance genes, antimicrobials and anti-microfouling agents, thanks to a hybrid workflow of in silico and microfluidics-based functional discovery, resulting in the commercialization ≥400 enzymes for biocatalysis and ≥2 new solutions for plastic/polymer degradation, increasing the revenue of our industrial partners by 10-15%.BLUETOOLS assembles 5 leading European companies, 8 academic teams and 1 private RTO that have pioneered approaches in functional metagenomics, microfluidics, microbial ecology and synthetic biology. The presence of diverse, complementary industrial stakeholders in the consortium (from pharma to materials science to sustainability) at different stages in the research-to-market process (from RTOs to SMEs to large end-users) provides a unique opp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Human monoclonal antibody therapy to prevent hepatitis C virus reinfection of liver transplants: advancing lead monoclonal antibodies into clinical trial' (HepaMAb), addressing dissemination and exploitation.

assistant: **Impact**

Worldwide, 200 million people are infected with the hepatitis C virus (HCV). An estimated 15 million individuals are living with HCV infection within the EU. The economic, health and societal costs of chronic HCV infection are significant. HCV is the principal cause of death from liver disease and the leading indication for liver transplantation. The only treatment for end-stage liver disease is a liver transplant, yet the transplanted liver becomes rapidly re-infected and is frequently destroyed within 5 years after transplantation.  In this cohort of patients current antiviral treatments are too toxic - there is an urgent need to develop safe and effective treatments for use in this setting. Human monoclonal antibodies (MAbs) that target virus entry, are as yet an underutilised and potentially highly effective and safe weapon in the armoury against HCV infection. The consortium has identified MAb leads which, in pre-clinical analyses, potently block HCV infection.  HCV exhibits a high degree of genetic and antigenic variability, which enables the virus to escape protective immune responses. Crucially, the lead antibodies identified by the consortium are capable of preventing infection by a wide range of genetically distinct isolates because they target highly conserved epitopes on the virus or host receptor molecules. This limits the chances of virus resistance. Also, each lead antibody targets a unique component of the viral entry pathway, thereby paving the way for powerful combinatorial approaches which maximises clinical potency. HepaMAb harnesses leading expertise in MAb technology, preclinical efficacy and safety testing, biomanufacture and clinical trial to progress at least one anti-viral and one anti-receptor human MAb to phase I/IIa proof of concept clinical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Talk and Look, Tools for Ambient Linguistic Knowledge' (TALK).

assistant: **Concept**

General aim: This project will generalise the TRINDI and SIRIDUS Information State Update"(ISU) approach to dialogue management to develop adaptive multimodal dialogue systems. It will also extend the use of abstract representation, in particular the use of domain ontologies, to increase robustness and reconfigurability of dialogue systems. While the project will build showcases for in-car and in-home information and control, the main aim is to advance our understanding of generic technologies that will extend the ISU approach to adaptive multimodal and multi-lingual interaction. The project will have scientific and technological impact as a foundation for adaptive, recon-figurable, multimodal dialogue systems. The delivery of information in an intuitive, conversational, user-adaptivemanner will result in more efficient and robust interaction with information technology applications, for many different individuals in society.Multi-disciplinary research areas: There are four main research themes, each corresponding to a core work package:- Unifying multimodality and multilinguality,-Automatic generation and reconfiguration of multi-modal interfaces,-Multi-modal presentation in the Information State Update approach,-Adaptivity and learning.Laboratory showcases: To enhance collaboration, technology development and transfer, and scientific impact, TALK will develop laboratory showcases in a variety of scenarios, including in-car dialogue systems and the automated home environment.Building expertise in the European Research Area (ERA): TALK will build on current European expertise in multi-modal dialogue systems and will consolidate advances made in former European research projects including TRINDI and SIRIDUS.The Consortium: TALK brings together internationally recognised,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New kinds of families, new kinds of social care: shaping multi-dimensional european policies for informal and formal care' (SOCCARE).

assistant: **Innovation**

This proposal addresses the implications of demographic, economic and labour market change in European society for social care provision for young children, and for disabled and older people. Securing sustainable provision of social care for their citizens is a major challenge to European welfare states. Three family types most at risk from change will be studied in the context of five different national environments. Social and structural adaptation will be analysed at the household level and the levels of policy provision and policy design. Findings will be disseminated and exploited in workshops with local service providers and managers and with an international expert group representing user groups from all current EU member states. The ultimate aim of the project is to provide a major input into the further development of viable social care policies in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cartography of biomedical engineering in europe (CHART)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The impact that medical ad biological engineering (MBE) , especially in relation with the ageing population, handicapped persons, infectious degenerative and chronic diseases, genome research and neurosciences, has on the health and well being of citizens and on healthcare makes it a relevant area for the ERA initiative. The ERA. initiative provides the MBE community with an opportunity to foster an increase in competitiveness of European industry. CHART uses this opportunity by structuring the MBE research area in Europe. This involves: - identification of actors engaged in MBE research, societies, industries, healthcare, -making a comprehensive interactive mapping of the MBE resources implemented as WWW site, -structuring the MBE research sector by identifying relevant sub-domains. An Expert Group comprising leading European MBE experts guides the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cavity-Integrated Electro-Optics: Measuring, Converting and Manipulating Microwaves with Light' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Electro-optic technologies have emerged as one of the leading platforms in both classical and quantum communication landscapes. The advent of circuit quantum electrodynamics (cQED) based on low-loss Josephson junction circuits has led to spectacular scientific breakthroughs in quantum science and technology. In recent years, these breakthroughs have been translated into commercial quantum computing efforts worldwide, targeting a market with an estimated value of 1 billion Euro. Despite these achievements, there are fundamental limitations to quantum technologies based solely on microwaves. Operating in a millikelvin environment, the space required for wiring and electronics as well as the associated heat loads are barriers for scaling up the quantum processors to the size needed to address societal challenges. Electro-optic interconnects capable of coherently distributing and transferring quantum information from superconducting processors to a room temperature environment would address this challenge.  Such devices would enable quantum processors to be scaled up in a modular fashion, which will be key to realizing complex and capable quantum machines that remain controllable and error-correctable. Moreover, these microwave-optical interfaces would also form the basis for efficient laser-driven microwave technologies relevant to sensing applications, such as microwave astronomy or robust and low-noise microwave amplification. In CIELO, we aim to lay the foundation for laser-based manipulation of microwave fields using cavity electro-optics, enabling amplification, quantum-limited optical detection, interconversion, qubit readout, laser cooling and masing, in stark contrast to the commonly used electrical techniques. We will leverage a combination of unique expertise in