RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'International reference laboratory based surveillance of multiple drug resistance (MDR) Salmonella and Vero cytotoxin producing Escherichiacoli (VTEC)'.

assistant: **Concept**

To collect standardised data on the anti-microbial resistance patterns of salmonellas isolated from humans. To facilitate the study of resistance mechanisms and their genetic control by arranging the collection of representative strains of MDR-salmonellas and co-ordinating the required research work between specialised centres, and where available compare the resistances' of animal isolates. To extend the typing of VTEC O157 for surveillance purposes.To pilot an international quality assessment scheme for laboratory methods used in the identification/typing of VTEC. To establish a core set of data items to accompany, where possible, each laboratory typed human VTEC isolate. To create an international database of human VTEC isolates which is updated regularly and is readily available to each participating team. To detect clusters of human VTEC isolate types in time, place and person and to bring such clusters to the attention of collaborators rapidly.The general increase in the incidence of multiple drug resistant (MDR) salmonella brings with it the threat of greater morbidity especially in those vulnerable to the effects of salmonella septicaemia. Because of the international trade in human food and food animals, the problems associated with MDR-salmonellas in one country may influence the situation in others. Europe wide surveillance of salmonella resistance will allow the formulation and implementation of appropriate control measures on an international scale.The incidence of Vero cytotoxin-producing Escherichia coli (VTEC) O157 in individual countries of the EU is small when compared to salmonella, however it is an important public health problem because of the associated high mortality and the serious complications of haemorrhagic colitis and HUS. During the past te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a chemical biology toolbox for deciphering the ubiquitin code' to be submitted under Horizon 2020.

assistant: **Abstract**

Cells respond to external and internal stimuli by dynamically altering the functional status of existing proteins via post-translational modifications (PTMs). One of the most common and versatile PTMs in eukaryotic cells is represented by the covalent attachment of the 76-amino acid protein ubiquitin (Ub) to substrate proteins (ubiquitylation). Substrate modifications range from a single Ub moiety being attached to a protein of interest to complex polymeric Ub chains that can also contain Ub-like proteins (Ubls). Ubiquitylation plays pivotal roles in nearly all aspects of eukaryotic biology and cells dedicate an orchestrated arsenal of enzymes to install (writer proteins), translate (reader proteins) and reverse (eraser proteins) these modifications. The entirety of this complex regulatory system has been coined the Ub code. As many different human diseases, including different types of cancer and neurodegenerative diseases are being linked to dysfunctions in Ubl-related pathways, it is of utmost importance to decipher the Ub code.Within Ubl-tool we devise a modular and interdisciplinary chemical and synthetic biology platform for studying aspects of ubiquitylation that are challenging or impossible to be addressed by more traditional technologies. We will develop innovative toolkits for generating defined Ubl architectures, including mixed, branched and hybrid Ubl chains and we will apply these tools for identifying novel reader proteins as well as for studying the functional impact of these complex types of modifications on critical cellular processes. Given its fundamental importance in eukaryotic biology, the Ub system has attracted considerable interest and promise as therapeutic target. We aim at identifying new drug targets within the Ub system by developing in c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Topologically Active Polymers' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Synthetic and biological polymers are everywhere, they make up a wide range of materials, from every-day plastics to living cell. The study of how polymers behave in solution is a well-established research field that allows the informed design of commercial products, from plastics to rocket propellant. Most of the polymers used in everyday applications have a fixed structure that cannot be changed in time and this assumption lies at the heart of classic polymer physics. In this project, I propose to shift this paradigm by considering polymers whose architecture can be modified in time via topological operations that cut and glue the polymers' backbone at the expense of energy. Polymers undergoing these operations can dynamically and selectively alter their architecture or topology and I thus name them ""topologically active polymers"" (TAPs).   This project is inspired by the facts that the DNA in every living entity is constantly topologically altered in time to fulfil a range of basic functions (e.g. cell division) and that DNA is increasingly employed as a building block for responsive and multifunctional materials. I propose to computationally design and explore generic systems of TAPs and then experimentally realise them as solutions of DNA functionalised by special classes of ATP-consuming proteins. These active complex fluids are expected to display unconventional behaviours intimately linked to the accessible space of topologies, their dynamic morphology and non-equilibrium kinetics. For instance, they are expected to selectively respond to the concentration of certain proteins, e.g. Topoisomerase, that are enriched in cancer cells.   Given the fundamental importance of polymer science and the ubiquity of topology-altering proteins in vivo, this exciting bottom-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Training programme on international research project development and management for young scientists from the academy of sciences of Albania (ASA)' to be submitted under Sixth Framework.

assistant: **Abstract**

The TRAINASA International Research Training Programme will focus on strengthening the research potential of young scientists from the Academy of Sciences of Albania (ASA) active in the field of natural sciences.The project will take the initiative to overcome major research barriers identified both inside the Academy - e.g. relatively high average age of scientific staff due to the low number of interesting scientific opportunities for Ph.D./post-doctoral researchers - and on policy/national level such as the depressingly low participation of Albania in specific thematic priorities under Community Programmes.Selected young scientists from ASA will take part in an intensive Research Training Programme carried out in Albania. The programme will comprise of lectures about theoretical and practical issues of managing international research projects, traineeship for selected candidates and final Brokerage Events for linking with research projects under formulation.The result of the programme will be a group of young ASA scientists, who will have a good understanding of developing and managing research projects in an international context from all different aspects (project cycle assessment, financial management, ethical issues) with the main focus on running and upcoming EC programmes (such as FP7).The result of the proposed integrated capacity-building programme will be a group of highly-qualified and motivated young ASA researchers, who fully understand the theoretical and practical aspects of managing international research projects and who will act as a motor for future international ASA initiatives.With the help of such competent researcher group we expect that this would help us integrate into European research instead of playing a second-rate role in international re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cohesin-mediated chromosomal looping: From linear paths to 3D effects', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The 3D organization of chromosomes within the nucleus is of great importance to control gene expression. The cohesin complex plays a key role in such higher-order chromosome organization by looping together regulatory elements in cis. How these often megabase-sized looped structures are formed is one of the main open questions in chromosome biology. Cohesin is a ring-shaped complex that can entrap DNA inside its lumen. However, cohesin’s default behaviour is that it only transiently entraps and then releases DNA. Our recent findings indicate that chromosomes are structured through the processive enlargement of chromatin loops, and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged. The goal of this proposal is two-fold. First, we plan to investigate the mechanism by which chromatin loops are formed, and secondly we wish to dissect how looped structures are maintained. We will use a multi-disciplinary approach that includes refined genetic screens in haploid human cells, chromosome conformation capture techniques, the tracing in vivo of cohesin on individual DNA molecules, and visualization of chromosome organization by super-resolution imaging. With unbiased genetic screens, we have identified chromatin regulators involved in the formation of chromosomal loops. We will investigate how they drive loop formation, and also whether cohesin’s own enzymatic activity plays a role in the enlargement of loops. We will study whether and how these factors control the movement of cohesin along individual DNA molecules, and whether chromatin loops pass through cohesin rings during their formation. Ultimately, we plan to couple cohesin’s linear trajectory along chromatin to the 3D consequences for chromosomal architecture. Together our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Problem Driven Innovation Support Initiatives for SMEs'.

assistant: **Innovation**

Public innovation agencies strive at keeping the pace of SME innovation support demand, and seek opportunities to implement programmes pivoted on new approaches.The INNOCHALLENGE project will engage a consortium of partnering innovation agencies in exploring operating principles underpinning “innovation challenges” and “inducement prizes”, which proved to effectively nurture open innovation at all societal levels.Once operating principles of challenges and prizes are understood, the project will deliver a fully actionable guide (Design Option Paper) to be utilized by EU innovation agencies willing to adopt a challenge-driven approach in activating innovation support initiatives for SMEs at a regional basis.INNOCHALLENGE objectives will be achieved by making use of the Twinning Advance methodology. Good practices of existing inducement prizes and innovation challenges from partnering regions will be collected and afterwards discussed and analysed during three regional workshops. Particular attention will be given to sharing practical know-how over the planning and execution of such initiatives, as well as distilling lessons learned.On the basis of such corpus of knowledge, a novel and standardized format of Innovation Challenge for regional SMEs will be designed by partners. The Design Option Paper (DoP) will include full implementation guidelines and practical suggestions on how to activate such initiative. Collected best practices will be attached to the DoP, which will be disseminated throughout partners’ EU-wide networks, such as three EIT KICs, the EEN, and TAFTIE. Local stakeholders will be involved in the INNOCHALLENGE peer learning and design process: this will allow for the designed initiative to fit with regional specificities such as Industry Clusters, align w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Harnessing Halogen Bond in Perovskite Solar Cells' (HaloCell).

assistant: **Innovation**

It is established that fossil fuels enabled a huge global economic growth although resulted to a fragile equilibrium between fuel prices and economic development, an unsustainable exploitation of the natural resources and prompted the ongoing environmental and societal crisis. Solar-driven energy production is pivotal for glass-architecture buildings, public transportation, domestic/corporate roof-tops/windows and rural areas (i.e. greenhouses); oriented to EU policies for Decarbonization of the EU building stock and European Green Deal for efficient, clean and cheap energy. In the last decade, solution-processable metal halide perovskite solar cells (PSCs), a technology originated from dye-sensitized solar cells (DSSCs), the most prominent alternative to the dominant (95% market stake) 1st gen. PVs, has emerged. Major drawbacks towards the commercialization of PSCs are the: i) instability in prolonged environmental exposure (moisture, oxygen, irradiation), ii) toxicity of employed lead and its derivatives (i.e. PbI2) and iii) crystal defects resulting in energy losses due to non-radiative charge recombination. HaloCell aims to hamper losses due to non-radiative recombination, embody protection towards environmentally driven-hydrolysis/oxidation and manage toxicity of PSCs and luminescent solar concentrators (LSCs), harnessing a holistic halogen bonding strategy. Multifunctional tailored organic compounds will be utilized to enable selective interplay with perovskite crystal lattice via halogen bonding interactions towards PSCs with power conversion efficiencies and long-term stability under stress conditions (illumination, high temperature, ambient air) exceeding current state-of-the-art. The newly-developed PSCs will be exploited as solar cells coupled to luminescent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MULTISCALE MODELLING OF THE RHEOLOGY OF MANTLE MINERALS', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Understanding mantle convection is essential to understand the thermal and chemical evolution of the Earth and to constrain the forces driving plate tectonics. The rheological properties of the mantle are traditionally inverted from surface geophysical data. Radial profiles of the viscosity are thus available but a lot of uncertainties remain.A more detailed model of mantle rheology could be obtained from the knowledge of the constitutive flow laws of mantle phases. A lot of progresses have been achieved to extend the P, T range accessible to rheological studies. However, constitutive flow laws are only available so far for minerals from the upper mantle. More severe is the timescale issue since phenomenological flow laws must be extrapolated over several orders of magnitude to be applied to mantle convection.Recently, a new field has emerged in materials science called multiscale modelling. It allows to link our understanding of a few elementary mechanisms (usually at the microscopic scale) with a behaviour observed at the macroscopic scale. I consider that this offers a ground-breaking opportunity to set a microphysics-based model of the rheology of mantle phases. Much progress has recently been obtained by my group in this direction. A multiscale model of plastic flow consist in modeling:a)the defects responsible for plastic shear at the atomic scale (dislocations);b)their mobility under the influence of stress and temperature;c)their collective behaviour resulting in plastic flow.I propose to build upon those accomplishments and to model the plastic flow of some key phases of the Earth’s mantle: wadsleyite, ringwoodite, MgSiO3 perovskite and post-perovskite to constrain:i)the viscosity contrast between the transition zone and the lower mantle;ii)the viscosity profil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'GAAS high index substrates for optoelectronics'.

assistant: **Innovation**

The objective of this project is to demonstrate that high efficiency, low threshold current, tunable, medium power lasers can be obtained on (111)B GaAs substrates, and that these lasers can also cover the 1.0-1.3 microns range. The material system GaInAs/AlGaAs/GaAs (100) reaches its limits around 1.06-1.1 microns, due to limitations associated to the appearance of dislocations in the strained InGaAs Quantum Well (QW) (Critical Layer Thickness, CLT, limit).The use of (111)B GaAs substrates allows to increase the critical thickness for PseudoMorphic InGaAs QW's. We plan to investigate the maximum reachable wavelength from strained InGaAs QW's grown on (111) GaAs substrates. Besides, this orientation offers a different valence band structure, that will allow to lower the lasing threshold current. High quantum efficiency is also expected because of the lower non-radiative recombination rates in this orientation. As another novelty, we plan to develop Bragg reflectors on (111)B GaAs substrates, to reduce the spontaneous radiative recombination, and thus to further lower the threshold current of such a laser diode. Another novel concept offered by (111) lasers is tunability, due to the presence of the piezoelectric field in strained quantum wells grown on polar orientations, this field being maximum for (111) orientations. The screening of the piezoelectric field can be used to adjust the wavelength by controlling the losses. We plan a practical approach to realise tunable lasers based on this principle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Micro-physiological circadian platform for safety and efficacy assessment of drugs and cosmetics' (2014-2020).

assistant: **Concept**

Tissue Dynamics Ltd. is a groundbreaking biotechnology company focused on developing smart microphysiological platform technologies for drug, food, and cosmetic development. Pharmaceutical and cosmetic companies face huge costs of developing and testing new products (an average of €2.5B to develop a single drug), which is increasing over the years. Traditionally, these tests have been carried out in animal models whose limitations in predicting human responses are significant (70% of drugs toxic to humans are not toxic to animals). These limitations lead to the withdrawal of many drugs in the market, making drug development a costly risky process. Organ-on-chip platforms, developed in recent years, have proven to be a better alternative to current laboratory models, offering more physiological and similar characteristics to the human body. Tissue Dynamics goal is to provide a functionally scaled Multi Organ-on-Chip (MOC) platform that uses real-time sensing of tissue function to detect the effect of drug-induced physiological stress in multiple 3D vascular organs (liver, heart, brain, kidney). Our latest innovation has been the incorporation of factors that mimic circadian rhythms in the organs, which is essential to test the physiological impact of the compounds tested. On the other hand, the incorporation of the circadian rhythm in our chips enhances the development of treatment schemes, adjusting in a more precise way the dose and the time of administration of the medications, seeking the maximum efficacy of them. The global Organ-on-Chip market is a rapidly-growing, estimated to reach $6.13 Billion by 2025, with an expected growth rate of CAGR 69.4%. Our platform will reduce the cost of new drugs development ultimately, helping patients by making more safe and effec