RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated resonant accelerometer microsystems for automotive applications' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

- Development of a 50g accelerometer sensor based on a bulk micromachined silicon resonator.- Development of a 500g accelerometer sensor based on a bulk micromachined silicon resonator.- Development of accompanying ASICs for integration with 50g accelerometer in a hybrid integrated microsystem for frontal impact airbag applications.- Development of accompanying ASICs for integration with 500g accelerometer in a hybrid integrated microsystem for side impact airbag applications.- Test and demonstration of the microsystems in the airbag application by Autoliv.- Development and installation of the mass fabrication of silicon microsystems, glass-silicon-glass bonding, assembly and test.A family of accelerometer microsystems will be developed for automotive applications based upon the following two types accelerometers.- Crash sensors for frontal impacts and airbag applications range around 50g- Crash sensors for side impacts and airbag applications range around 500g.The project will focus on the development of key process technologies including assembly and testing, product designs and manufacture and test of functional prototypes in coordination with the establishment of high volume production capabilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Population Medicine and Sustainable Development: European Opportunities in collaborating with China to improving global health.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The overarching objective of this Staff Exchanges (SE) program is to form an international network of organizations from Spain, Germany, Slovenia, and China, working on a joint research program in the fields of health, development economics, and anthropology. Population medicine is a new medical paradigm that aims to improve the aggregate and long-term population health by mobilizing available resources through various care responsibilities. The principles of population medicine are aimed at forcing doctors and physicians to shift from a reactive model that treats ill individuals to a proactive model that focuses on the population's health. This SE Program focuses on how economics, as a collection of theories, models, techniques, and values, might enable practitioners in providing better and more efficient treatment to the population they serve. The People’s Republic of China has become a global leader in large-scale preventive screening and the digitalization of healthcare, making essential strides towards a population medicine paradigm.23 researchers will conduct 144 PMs of secondments in Training, Data Collection, and Research Work in the four countries to Develop an economic framework for population medicine, estimate the causal impact of renewable energy and digital telecommunications infrastructure on sustainable development outcomes, and conduct a social and cultural analysis of the effects of health and sustainable development policies on European immigrants in China.The results will enable European and international medical training institutions to develop better programs and solutions to target and improve the aggregate health of their respective societies. It will bring together these existing collaborating partnerships into an interdisciplinary consortium th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coordinating Air transport Time Efficiency Research' (CATER).

assistant: **Concept**

Europe, through the High Level Group on Aviation Research, ACARE and the Commission, has a vision for air transport in meeting societal & market needs over the coming 30 years.  Central to this is time efficiency, meaning reduced door-to-door journey  times, seamless inter-modal connections and reliability.  For this Europe will engage in large scale, intensive and coordinated research &  innovation.  Stakeholders need a full picture of what research is being conducted, of gaps present and how EU funded R&I meets ACARE goals.  CATER will be an R&I observatory and policy centre run by an expert group with deep industry knowledge, access to a network of all relevant organisations and excellent information gathering and knowledge management processes and tools.  CATER will deliver valuable and insightful reports and recommendations, packaged and disseminated effectively.  CATER will conduct an annual review of the state of the art of R&I, identify gaps in the landscape and bottlenecks to innovation and formulate strategic recommendations to address these.  It shall review the landscape in the context of the six Activities of the Specific Programme and the Strategic Research & Innovation Agenda of ACARE. It shall provide a dashboard of relevant funding programmes.    It shall complement SESAR and other EU research coordination initiatives. CATER will develop a web-site, tool-set and knowledge base that centralises and updates information by way of advanced automated web search tools.  The centre shall act as network hub for time efficiency stakeholders enabling them supply and harvest relevant knowledge.   Dissemination of the reports and findings shall be through consultation with stakeholder leaders and through the online platform, workshops, outbound communications and p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Signaling initiation and specificity in BAK1-dependent receptor kinase-mediated innate immunity in Arabidopsis'.

assistant: **Concept**

Surface-localized pattern-recognition receptors (PRRs) detect microbes by recognizing conserved pathogen-associated molecular patterns (PAMPs). The Arabidopsis leucine-rich repeat receptor kinases (LRR-RKs) EFR and FLS2 recognize the bacterial PAMPs EF-Tu and flagellin, respectively. Although the overall importance of PAMP-triggered immunity (PTI) for plant defense is established, the mechanisms linking PRR activation at the plasma membrane to intracellular signaling remain largely unknown. Our long-term objective is to understand how plants perceive and signal in response to microbes to mount efficient disease resistance. The overall aim of this proposal is to decipher signaling initiation and specificity during RK-mediated innate immunity in plants. The central hypotheses of the research are that (i) the ligand-binding LRR-RKs FLS2 and EFR form dynamic complexes with multiple regulatory proteins upon PAMP binding, which are essential to signaling initiation, (ii) phosphorylation events between the ligand-binding PRRs and the regulatory LRR-RK BAK1 are key for signaling initiation and specificity, and (iii) new sensitized forward genetic screens can identify novel important immune regulators. The rationale behind this research is based on exciting new data showing that (i) the properties of the non-RD kinases FLS2 and EFR are distinct from the paradigmatic RD kinase BRI1, (ii) the function of BAK1 in immunity, growth and cell death control can be uncoupled mechanistically in a phosphorylation-dependent manner, and (iii) a suppressor screen identified several modifiers of bak1-5 (mob) mutants.To achieve our goal, we will pursue the following specific objectives:1. Decipher the composition, stoichiometry, cellular localization and dynamics of the FLS2/EFR-BAK1 complexes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bio-physico-chemical Insights by Fluorescence-free Flow-induced Taylor Analysis using Neuronal Networks for Ensembles of Nanoparticles' under Horizon Europe.

assistant: **Concept**

Characterizing polydisperse suspensions made of complex microscopic entities is a key task for most control and purification processes in the water-treatment, pharmaceutical, agri-food and cosmetics industries. Existing methods and products to perform such a task are often costly, low-throughput, large-volume, mono-modal, label-based, with moderate resolution, and typically only provide partial information such as an average particle size. By substantially benefitting from the fundamental knowledge produced, as well as the practical methods and equipment developed and assembled within the context of the mother ERC-CoG project on transport of microscopic entities in confinement, the current application ambitions to overcome the above limitations. The main goal is to develop and valorise a novel and versatile bio-physico-chemical characterization platform. It aims at combining in a unique fashion state-of-the-art microfluidic, imaging and deep-learning methods, through absorption-based Taylor-dispersion analysis, spectrometry, and advanced statistical inference. Importantly, the platform is expected to be low-cost, high-throughput, low-volume,label-free, high-resolution, and to provide access for the first time to the full distribution of sizes and formulation of complex suspensions of any microscopic agents of interest. The program is divided into four work packages, respectively dealing with: the mounting of the ultra-stable microfluidic platform with automated robotic arms for product selection and injection; the imaging and characterization tests on suspensions, with increasing degrees of complexity; the implementation of AI methods for high-dimensionality statistical inference; and the valorisation and refined market identification. Preliminary results already obtain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Sorting and export of mucins.'.

assistant: **Innovation**

Inflammatory Bowel Diseases (IBD) affected more than 6.8 million people worldwide in 2017, and Chronic Obstructive Pulmonary Disease(COPD) caused 3.23 million deaths in 2019. Both illnesses present a disturbance in the quantity and quality of mucus due to an abnormal expression and secretion of mucins. The mucins are the main component of mucus and are specifically expressed in cells and tissues. Mucin secretion is crucial for the normal physiology of wet mucosal epithelium. Growing data shows that alterations in mucins expression and their localization are related to pathological processes, such as inflammation, infection, autoimmunity, and cancer. All mucins are synthesized in the endoplasmic reticulum and exported to the Golgi complex, and after extensive glycosylation, are transported to the plasma membrane. However, how these mucins are sorted and packed into granules that can reach micrometers in size remains largely unknown. I hypothesize that transmembrane and secreted mucins are sorted and packed in separate containers by regulatory partners, different from those involved in other bulky-cargo pathways – as collagen –. The Malhotra lab is a world-leader in the study of protein secretion. Recently, I have tagged mucins with fluorescent proteins by CRISPR/Cas9 gene-editing technology, which will allow me to understand these glycoproteins from synthesis to functional target. Unveiling this fundamental knowledge could stimulate the development of therapies aimed to modulate the expression and precise release of mucins, both in pathologies due to mucin hyposecretion – such as IBD – and hypersecretion – observed in COPD –.


**Keywords:** Mucins, Protein-sorting, Protein-trafficking, Bulky-cargoes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'LEAF: heaL thE plAnet's Future'.

assistant: **Concept**

The main objective of the LEAF (heaL thE plAnet's Future) project is to increase the awareness on the importance of research and innovation and improve trust in the researcher's work by effectively involving the society in experimenting science through 400 hands on events focused on a set of EU Green Deal selected topics (Farm to Fork, Biodiversity, Circular economy, Zero-pollution, toxic-free environments, Health & Wellbeing). The main goal is to make science accessible and fun to everyone, thus generating a practical understanding of how to cope with climate change issues. The LEAF project will be developed in 11 cities in Italy, thus involving 31 partners with a series of events happening between 20 to 25 of September 2020. The final result will be a relevant increase in the awareness of why and how the researcher's work is relevant for the benefit of our current and future planet, as well as effectively encouraging young people in embarking in scientific careers by generating a real impact on science.


**Keywords:** Climate change, resilience, circular economy, science communication, science, research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimizing access to long-term care? Impact of long-term care policies on use, health and equity among the elderly' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

OECD countries face the aging of their population, a demographic trend that will amplify in the next decades. This causes a substantial increase in the number of the disabled elderly, who require assistance with activities of daily living. Reconciling the societal concern for ensuring appropriate long-term care (LTC) to the disabled elderly and the pressure on public spending is a major challenge that all OECD countries struggle with. Governments aim at containing rising LTC costs by setting eligibility criteria and cost-sharing rules; such measures may however impact the efficiency and equity of LTC policies. How does the design of LTC policies affect LTC use at both the individual level and across population groups? And what are the downstream effects LTC use may have on health and health care use? This proposal aims at providing robust empirical evidence on these questions by making use of conceptual and measurement tools from applied economics. Identification of causal relationships will be achieved by exploiting quasi-experimental variation in LTC use and innovative individual-level data, which combine survey and administrative sources.My research will yield three main contributions to the economic literature and to our understanding of LTC policies. First, I will provide unprecedented insight on the impact of co-payments on nursing home entry in a European country, namely the Netherlands. Second, I will assess whether the under-use of LTC may deteriorate health and increase health care services. Finally, I will provide a comprehensive assessment of socio-economic inequalities in the use of LTC and its financing in France.This proposal tackles research questions that the international literature has left pending, in the context of two countries whose ongoing policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Training Network to Understand and Exploit Mechanisms of Sensory Perception in Bacteria' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The PATHSENSE (Pathogen Sensing) ETN will bring together an interdisciplinary team of world-leading researchers from Europe to tackle a highly ambitious scientific project, focusing on the molecular mechanisms of sensory perception in bacterial pathogens. PATHSENSE will establish an innovative doctoral training programme that will deliver 13 PhD graduates and high-impact scientific outputs. The relationship between molecular structures and biological function is central to understanding any living system; however the research methodologies required to unravel these relationships are often complex and fast-changing. The team participating in this Network has the infrastructure and track-record to train ESRs in these state-of-the art methodologies, including structural biology, proteomics & protein biochemistry, molecular biology, bacterial genetics, food microbiology, mathematical modelling, cell biology, microscopy and comparative genomics. PATHSENSE will investigate the poorly understood structure-function relationships that exist within a large multi-protein complex called a “stressosome”, which acts as a sensory organelle in bacteria. The project will involve extensive inter-sectoral mobility of the ESRs across 7 EU countries to make full use of the complementary skills available at each of the hosting institutions. The inter-sectoral Network comprises 8 leading Universities, 1 public research institution, 4 companies (from spin-off to large multi-national) and 1 governmental agency. A major objective of this Network will be to exploit the fundamental research to develop novel antimicrobial treatments that have applications in the food and public health sectors. This project will deliver high-impact science, 13 highly-trained innovative researchers and will produce a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Scalable inference algorithms for Bayesian evolutionary epidemiology' (SCARABEE) under Horizon 2020.

assistant: **Objectives**

Advances in sequencing technologies are currently providing an unprecedented opportunity to a detailed discovery of the mechanisms involved in the evolution and spread of microbes causing human infectious disease. Simultaneously the developers of statistical methods face an enormous challenge to cope with the wealth of data brought by this opportunity. We have very recently demonstrated the ability of our advanced computational approaches to deliver breakthroughs in understanding pathogen evolution and transmission in numerous highlight results published in Science, PNAS and top-ranking Nature journals. The rise of microbial Big Data gives a promise of a giant leap in making causal discoveries, however, the existing statistical methods are neither able to cope with the size and complexity of the emerging data sets nor designed to answer the novel biological questions they enable. To fulfil the promise of giant leaps SCARABEE will leverage scalable inference methods by a unique combination of machine learning algorithms and Bayesian statistical models for evolutionary epidemiology. We focus on central biological questions about adaptation, epistasis, genome evolution and transmission of microbes causing infectious disease. The Big Data combined with the novel inference methods will make it possible to answer a multitude of important questions that remain currently intractable. Through our close collaboration with the leading research centres in infectious disease epidemiology and genomics we expect the SCARABEE project to considerably advance understanding of the evolution and transmission of numerous pathogens that pose a major threat to human health, which will be important for reducing their disease burden in the future. Large-scale biological data will be used to ben
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Evaluation of selected natural topoisomerase poisons in human cancer cells.' in the context of a Fifth Framework call.

assistant: **Objectives**

Evaluation in human cancer cells of non-toxic natural compounds that have show interest as topoisomerase poisons. The active ones will be evaluated in combination with some currently used anticancer drugs to detect a synergism that might be used to decrease their toxicity limiting their usefulness.