RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Active regulation of growth and division controls the spatio-temporal organization of living organisms' (GrowDiv) under Horizon Europe.

assistant: **Objectives**

Biological systems such as developing organisms, growing tissues, or expanding bacterial biofilms depend on two key processes—cell division and growth. While division increases cell numbers, growth enlarges individual cells. These active processes shape large-scale properties such as division waves, mechanical state transitions, ordered spatial arrangements, and cell size regulation. Though division and growth are often coupled, they can also operate independently, complicating their influence on tissue mechanics and organization. For example, spatially coordinated division and its role in pattern formation have been underexplored, especially in particle-based models that account for individual cell dynamics. This project, GrowDiv, focuses on understanding how biological systems with uncoupled division and growth achieve robust spatial and temporal organization.Working closely with experimentalists studying the self-organization of Xenopus laevis embryo cytoplasm, I will use a numerical particle-based model to investigate the impact of growth and division timescales on three major transitions: (i) from steady division waves to chaotic dynamics, (ii) from fluid to solid-like states, and (iii) from ordered spatial arrangements to disordered configurations. In particular, I will simulate how independent growth and division lead to stable organization, comparing theoretical predictions to experimental results on cytoplasmic dynamics and microtubule asters. The project will reveal how large-scale biological self-organization emerges from the intricate interplay between division and growth, providing deeper insights into early embryogenesis and the mechanical properties of living systems.


**Keywords:** Oscillating active matter, synchronization, tissue mechanics, pattern fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Unravel the role of extracellular NNMT (eNNMT) in the modulation of prostate cancer (PC) tumor immune microenvironment (TIME)'.

assistant: **Objectives**

Prostate cancer (PC) is the most common male cancer in the United Kingdom and more effective treatments are needed to control the lethal late-stage disease, termed castration-resistant PC (CRPC). CRPC is largely refractory to immunotherapeutic interventions mainly due to its tumour-immune microenvironment (TIME) with low infiltration of activated anti-tumour immune cells.Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme which catalyses the transfer of methyl groups from S-adenosylmethionine to nicotinamide. Independent studies have implicated NNMT upregulation in sustaining aggressiveness of a specific subset of CRPC with stem cell-like features (CRPC-SCL), in several cellular and organoid models. We’ve recently described a “moonlighting” function of this enzyme, which can be secreted by cancer cells (extracellular NNMT – eNNMT) and activate TLR4-dependent NF-kB signalling in macrophages. Preliminary data demonstrate that PC secrete eNNMT, but how eNNMT may modulate the TIME, remains unknown.This project aims to elucidate the role of eNNMT in shaping the TIME of CRPC-SCL. eNNMT release by CRPC-SCL murine cells and organoids, overexpressing NNMT will be quantified by ELISA. Using the state-of-the-art micro-mapping technology, we will identify eNNMT interactors in immune cells, to gain insight into the signalling pathways primed by eNNMT. Functional assays will be performed in co-cultures of CRPC-SCL models and immune cells, in the presence or absence of eNNMT blockage. Defining eNNMT as a mediator of immune modulation in CRPC-SCL will provide mechanistic insights into tumour–immune crosstalk and establish the basis for novel immunotherapeutic strategies using eNNMT-neutralizing antibodies. Importantly, this project will also establish a pipeline to identify i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Growing Climate Resilience in Remote rural Areas through Community Empowerment' (GRACE).

assistant: **Innovation**

Europe is warming faster than any other continent, with 2023 being the hottest year on record. This rapid Climate Change (CC) increases the frequency of extreme weather events, such as floods, wildfires, and droughts, endangering people, infrastructure, ecosystems, and the economy. From 1980 to 2020, climate disasters cost the €12 billion annually, and future hazards could raise this figure to €170 billion per year. In response, the European Commission (EC) has enacted policies like the European Green Deal (EGD), the European Adaptation Strategy, and the European Mission on Adaptation to Climate Change (MACC), all aiming to boost resilience, particularly in rural areas that are disproportionately vulnerable due to their dependence on natural resources and exposure to diverse climate risks. Rural areas, especially Remote Rural Areas (RRAs), face even greater obstacles like lower institutional capacity, underinvestment, and depopulation, limiting their ability to adopt climate adaptation measures. Covering 50 % of the European Union (EU)'s rural territories, RRAs urgently need empowerment to tackle CC effectively. GRACE project focuses on addressing the needs of rural and small and medium communities localised in EU RRAs to adapt and build resilience against CC, by strengthening their capacities and empowering them to become actors of change and take transformative action. A consortium of 27 organizations from 16 countries implements the project, with 5 Demonstrator Regions (DRs) in Austria, Denmark, Italy, Portugal and Sweden co-developing innovative solutions centered on nature-based approaches. These solutions are designed to deliver multifunctional, place-based social, environmental and economic benefits. In addition, circular economy principles will be embedded withi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Elimination of end-of-life cost through a standardised simultaneous design methodology for SME supply chains' to be submitted under Fourth Framework.

assistant: **Abstract**

EU, a trend-setter in environmental legislation and the environmental awareness of the customers, will force manufacturers to be responsible for their products and to take back out-of-use products at end-of-life (EOL). The corresponding take-back legislation in member countries is enacted or anticipated. This additional responsibility for their products at EOL is causing concern for the whole manufacturing industry as it is unsure how it will finance such a responsibility, particularly with regard to the disposal and recycling cost. Only economical recycling can be the ultimate incentive for companies to support Circular Economies. However, product design intended to eliminate recycling cost and generate end-of-life value requires simultaneous and standardised optimisation of the entire product, including the numerous components and modules from suppliers, which are mainly SMEs. ElectSME will deliver an integrated 2nd generation DFR- methodology to European industry, based on and going clearly beyond the 1 st generation tools developed in the frame of Brite-EuRam like DEMROP and TOPROCO, combining and expanding the core consortia of both projects. The methodology will be generic and adaptable to other technical products, even though it uses Electrical and Electronic Equipment (EEE) as a test bed.ElectSME will provide innovations on:- how to co-operatively and simultaneously eliminate EOL cost over entire supply chains;- how to bridge the gap between designers and recycling companies' know-how by providing multiple recycling databases for reliable EOL optimisation;- how to include all available recycling technologies from material down- cycling all the way to product or component refurbishment, re-utilisation and reuse;- how to reflect future recycling technologies by me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hazardous Pesticide Bans and Early-Life Health Outcomes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Farm to Fork strategy aims to reduce hazardous pesticide use by fifty percent by 2030 to help achieve a climate neutral Europe but it is still an open question whether potential benefits of the proposed strategy can outweigh its costs. Therefore, it is crucial to examine if eliminating harmful pesticides can provide significant health improvements and to weigh these health benefits against the potential economic costs of adopting safer but less effective plant protection practices. The project's main objective is to examine the impact of hazardous pesticide bans on early-life health and economic outcomes in Türkiye.PESTBAN will expand the state-of-the-art knowledge on economics of pesticides in several aspects. First, it will contribute to previous studies on pesticides and health by comparing early-life health outcomes within agricultural areas as they switch from hazardous pesticides to safer alternatives. Second, the project will contribute to existing literature on economics of pesticide bans by monetizing the health gains from harmful pesticide bans and comparing these benefits to economic impact of bans on agricultural production areas. The project has the potential to encourage adoption of stricter regulations on hazardous pesticides by highlighting the health benefits of pesticide bans.Specific aims of the project include (1) data collection on hazardous pesticide use and established bans in Türkiye, agricultural production and crop prices; acquisition of individual health data from national birth registry and national health surveys; (2) empirical analyses to investigate economic and health effects of pesticide cancellations established between 2005 and 2015; (3) implementation of models from soil and water sciences to evaluate the pollution potential of ground
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mutual European and Japanese Initiative for Interoperability' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Smart MEIJI is a joint project to exchange information and contribute to smart card interoperability between EU and Japan by:- launching a strong co-operation platform between Japan and Europe to promote the use of the smart card;- maximising interoperability of smart card systems on specific issues such as contactless and security;- organising joint workshops bridging European researchers (Eurosmart Association and eEurope Trailblazers groups) and Japanese experts (NMDA Association and other professional representative structures);- enabling a validation of the work by competent technical committees and certification bodies (e.g. DCSSI, BSI, CESG, MITI);- disseminating information and knowledge through high level conferences, regular Newsletters and mutual web sites.Objectives:The Smart MEIJI proposal will cover interoperability and harmonisation of smart card systems, essential elements for the acceptance of smart cards.The specific objectives of Smart MEIJI are to:- pool the know-how of European and Japanese industry;- strengthen links between the European Smart card Industry and the Japanese Smart card Industry;- promote wider deployment of the outcome of the eEurope Smart Card Charter action plan;- exchange information in order to encourage technical and other co-operation outside Europe.Benefits will be major interoperability of smart card based systems and effective co-operation and dissemination between European and Japanese technology.Work description:The actions provided by Smart MEIJI are structured into three work-packages:- Work-Package 1 (WP1): Pooling of know-how;- Work-Package 2 (WP2): Information Dissemination and Exploitation;- Work-Package 3 (WP3): Project Management WP1 provides the essential framework of this initiative by gathering the Japanese kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Distributed crisis management using remote collaboration technologies' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

In a world where the threat of terrorism and environmental disasters are on the increase it is imperative that our ability to instantly collaborate, decide on a course of action and respond, improve dramatically. This proposal addresses this need by combining the remote collaboration technology capability developed by the researcher with the human supervisory control expertise at the Massachusetts Institute of Technology (MIT). Traditional command structures in this domain follow a rigid hierarchy but wit h the widespread adoption of ubiquitous computing facilities by emergency personnel the communication structure can be re-evaluated.This project will therefore address the support of lateral relationships between operators in a crisis management setting b y using the novel desk-based remote collaboration systems called the Escritoire to support distributed decision making and human supervisory control (HSC). The researcher in this proposal developed the Escritoire during his PhD which was funded by Thales Research and Technology (TRT) and inspired TRT to set up a team of industrial researchers in this field, the Virtual Collaboration Solutions (VCS) group, located in the UK on the campus of the University of Surrey.In this project the researcher will spend two years in the USA at MIT's Humans and Automation Lab (HAL) learning about, and applying his technology to, HAL's core research field: decision making and HSC. During his time at HAL the researcher will maintain close liaison with the VCS group and after 2 years move to the UK to incorporate his new knowledge in Thales' crisis management test bed, share knowledge in the VCS team and present his results throughout Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Millimeter Wave Massive Arrays enabling RFID/Radar Applications on 5G Smartphones' (MAPS) under Horizon 2020.

assistant: **Objectives**

Nowadays, a rising interest is moving towards the fifth generation (5G) of wireless mobile communication, as numerous devices and different heterogeneous networks will be interconnected, guaranteeing zero-distance connectivity between people, devices and objects. To deal with the ever increasing data traffic demand and the low power consumption requirements in the perspective of a sustainable growth, smart solutions have to provide energy- and cost-efficient services. In this context, the massive antenna arrays deployment in base stations, access points or smartphones, appears like a viable solution to meet these new challenges. Besides communication, the availability of such a technology can also allow other interesting applications such as accurate simultaneous localization and mapping (SLAM) performed by a personal radar integrated in smartphones, enabling new services in the device-to-device communication. In addition, the interrogation of tagged objects placed in the environment through radiofrequency identification (RFID) technology will allow a mapping of the real world into the internet space, enabling environment-related applications and constitute the so called smart space within the Internet of Things concept. Moreover, the reduced wavelength at millimeter-waves (mmW) paves the way for packing a large number of antenna elements into a small area, overcoming the difficult integration of laser-based or mechanical steering devices into mobiles.   In this context, the project addresses in a unified framework the problem of achieving environment 3D mapping and objects identification by means of massive antenna arrays embedded on smartphones, which have the capability to learn from the environment and consequently continuously improving their performance. An offlin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Flexible Access Cluster for Integrated microsystems with Low cost of Entry'.

assistant: **Innovation**

The aim of this Europractice Project is to establish a flexible manufacturing cluster to provide commercial access to integrated microsystems incorporating sensors and microelectronics. The dual-centre cluster incorporating a dedicated MST facility and a standard CMOS foundry will reduce barriers to entry and risks by providing low-cost prototyping and low-volume manufacture before committing to volume production on the same processes. The cluster will offer a combination of technologies and potential products and solutions which is not generally available elsewhere, focused on integration of components with associated control and data processing electronics. Processes include CMOS-compatible low temperature metal/nitride based surface micromachining and high aspect ratio deep reactive ion etching of thick SOI, with monolithic integration. The consortium consists of QinetiQ (co-ordinator and low-cost prototyping), Coventor (design software/consultancy) and European Semiconductor Manaufacturing (foundry).Objectives:- Provide access with reduced costs/risks to MEMS products for SMEs and medium/large companies by establishing a seamless one-stop service, including design, product development, prototyping, packaging and low/medium/high volume production in integrated microsystems for rf/sensor/transducer applications;-Offer a flexible dual-centre microsystems technology (MST) prototyping/ production capability with the same processes, with low-cost prototyping and flexible low-volume manufacture at a dedicated MST facility and potential volume manufacture via a pure play standard CMOS foundry;- Offer a range of Si-based processes not generally available including:- Fine geometry poly-Si sacrificial surface micromachining (SSM) (0.2-2 micron)- CMOS-compatible low temperature
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Total optimisation process based on field data transfer for european machine builders'.

assistant: **Concept**

Machine life cycle cost and reliability are important decision criteria and have strategic impact on the European machine tool building industry. Service is often provided by the customer or service providers. Thus, machine tool builders do not get sufficient information to estimate life cycle cost and reliability. They also lack adequate methods/techniques to improve current and future products systematically.It is the objective to develop a field data based optimisation process for the machine tool building industry with field data collection and methods/ techniques support, comprising design, production, service and use. A software tool will be developed to support the optimisation methods and techniques for field data feedback and exploitation. To ensure the acceptance of the approach win/win situations for information suppliers and users will be developed.