RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unravelling the nano-landscape of receptors controlling molecular processes of the immune system' (IMMUNANOMAP) under Sixth Framework.

assistant: **Objectives**

The major objective of IMMUNANOMAP is to rain the next generation of multidisciplinary researchers to operate at the intersections of nano-technology, nano-chemistry, molecular cell biology and immunology. Interdisciplinary researchers are needed to develop tools and insights into our molecular understanding of the cell as a central entity of all living organisms and unravel the mechanisms underlying the defence against pathogens. Novel microscopic techniques now provide the tools to cell biologists and immunologists to study cellular processes at the nanometre and single molecule scale.Particularly in the immune system, which defends our body against pathogens, the recognition and elimination of nanometre-sized pathogens is regulated through complex cell signalling to ensure a swift and effective protective response. How these cell surface processes are orchestrated is poorly understood. For the first time, the technology is within reach to unravel the nano-landscape of surface receptors of cells of the immune system and get dynamic information of their organization and subsequent signalling pathways at the nano-metre level.We hope to reach out goal by:1) Thorough multidisciplinary training both at the theoretical and practical level to a truly interdisciplinary field of young and experienced researchers consisting of physicists, surface chemists, cell biologists and immunologists, and2) exploiting state-of-the-art imaging techniques to understand the molecular organization of cell surface and signalling pro cesses pertinent to the functioning of the immune system.Thus we anticipate eliminating a major limitation in multidisciplinary work that restricts scientific and economic progress due to fundamental differences in the background of scientists in these diverse disc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Polymer-Nanoparticle co-assembly for drug targeting and release kinetics: Investigation on Structure, Morphology, Responsiveness, and Nanoparticle distribution'.

assistant: **Innovation**

In recent years, co-assembly of nanoparticles (NPs) into block copolymer (BCP) aggregates is emerging as an active field of research, which considers the formation of mixed aggregates that combine synergistically the NP/BCP components to generate novel properties for advanced functional materials and applications. When NPs have been incorporated into the BCP micellar aggregates, various physical parameters e.g. distribution, the content, orientation, and localization of NPs in the polymeric matrix are extremely important, which play decisive roles in determining the characteristics and applications of the NP/BCP nanohybrid.In this proposal, we aim to investigate the morphological transformations of selected model BCP micelles in the presence of magnetic NPs of different size, shape, concentration and surface functionalization. Simultaneous encapsulation of the drug molecules controlled by the NP distribution and loading will provide critical information on the correlation of drug release with the physical parameters characterizing the polymer nanohybrids. We will also examine how the distribution of NPs within co-assembled structures is correlated with the parameters characterising the polymers and NPs. The drug release kinetics for selected nanohybrid systems will be investigated to rationalize the correlation between precise control of NPs localization/drugs loading with the drug release profile. Doxorubicin (Anti-cancer drug) containing BCP-NP nanohybrid will be formulated by solvent assisted dispersion technique. The drug release kinetics will be investigated by dialysis against tris buffer (pH 7.4/5.0) at 37oC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Green-health-safety Nexus for new Urban Spaces' (GreeNexUS), addressing dissemination and exploitation.

assistant: **Impact**

In our increasingly anthropised planet, many cities are facing multiple societal and environmental challenges and the link between the characteristics of the urban green contexts and people’s health and safety represents an emerging topic and of urgent importance. Air pollution and urban climate, reduced contact with nature, limited access to quality green spaces, and urban fabrics and infrastructure that discourage sustainable&safe mobility and active lifestyles, are threatening the mental and physical well-being of an aging society and increasing its social disparities. The GreeNexUS project proposes a novel and multidisciplinary approach to promote urban greening, territorial regeneration and safety/accessibility/walkability of urban infrastructures, as key strategies to face those challenges, while addressing climate change and preventing pandemics from exacerbating inequalities in disadvantaged/vulnerable groups. The GreeNexUS participants (20 institutions from 9 European countries) are joining forces to offer a collaborative Training-through-Research programme involving universities, research centres, companies, NGOs, and local authorities that share this new vision of fostering greener, healthier and safer urban realms of Europe’s cities and towns. This will drive the GreeNexUS process to train specialists, whose cutting-edge and intersectoral expertise will be developed and managed through a challenging general programme of training that combines and integrates the various fields of innovative knowledge of the GreeNexUS’ participants, and also includes career planning, entrepreneurship and soft skills training. In terms of research, 10 specific and multidisciplinary topics will be addressed by 10 Doctoral Candidates, who are envisaged to spread the GreeNexUS app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Studying ultrafast opto-magnetism in space and time with femtosecond temporal resolution and nanometer spatial resolution' (2007-2013).

assistant: **Innovation**

Ultrafast magnetization is of great interest, because new developments in this field could lead to faster, more compact magnetic recording technology where the ultimate technological goal is “smaller and faster” . Central to addressing this challenge is the development of novel experimental tools to directly look at the interplay between magnetism and individual nanostructures resulting from the quantum mechanical exchange interaction . Here we propose working towards an instrument that has unique capabilities for measuring the temporal spin dynamics of magnetic nanostructures with subwavelength spatial resolution as a first step towards understanding and controlling spindynamics on both nanometer spatial and femtosecond temporal scales. To achieve measurements on these unprecedented scales, we will combine two powerful techniques: Near Field Scanning Optical Microscopy (NSOM), which allows for nanometer-scale spatial resolution and a variant of Spectral Interferometery which allows for complete measurement of the light’s electric field (i.e. the intensity and the phase) on a femtosecond time scale. This will be implemented in a pump-probe configuration using NSOM in excitation mode to probe the sample with a subwavelength spot of light having a well defined spectral phase and polarization state. By scanning the probe pulse across the sample we can measure E(t,x,y) of the probe with femtosecond temporal and nanometer spatial resolutions which should reveal how the ultrashort pulse evolves in space and time as it interacts with the magnetic nanostructure. This will in turn reveal the temporal evolution of the material properties at each spatial location on the sample. By pushing the temporal and spatial resolutions of time-resolved magnetic imaging to its limit , we hope
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Targeting Real chemical accuracy at the EXascale' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

TREX is a highly integrated initiative that gathers most European leading scientists in quantum mechanical simulations of extreme accuracy in the framework of stochastic quantum Monte Carlo methods. This methodology represents one of the highest steps in precision in the ladder of electronic structure approaches and is uniquely positioned to fully exploit the massive parallelism of the upcoming exascale architectures. The marriage of this sophisticated approaches with exascale computing is bound to enable molecular simulations of unprecedented accuracy for complex scientific and industrial applications, meeting the growing demands for robust and predictive calculations in materials design. Thanks to co-design activities with leading high-performance computing (HPC) stakeholders, TREX will deliver a sophisticated product consisting of a user-friendly, high-performance software platform in the domain of stochastic quantum chemical simulations, which will enable the convergence of HPC and high throughput computing (HTC), and which will be made fully available to the computational community in academia and industry. Finally, TREX will work on show-cases to leverage quantum Monte Carlo methods for commercial applications as well as develop and implement software components and services that make it easier for commercial operators and user communities to use HPC resources for these applications.


**Keywords:** Quantum chemistry, materials science, quantum Monte Carlo methods, exascale, performance optimization, high-performance library
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chrome plating without toxic Cr(VI). An ecofriendly electroplating for automotive plastic parts.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Electroplating is one of the most advanced techniques to create plated plastics with wide industrial applications. However, current electroplating techniques use hexavalent chromium (Cr [VI]) as etching agent. Hexavalent chromium has been proved to have toxic, mutagenic and cancerogenic effects for human health. As a result, the European Union has included this compound within the list of restricted substances under the Directive 76/769/EEC (REACH Directive) and banned its use from 2017 onwards, while strengthening environmental, health and safety legislations on hazardous waste. This has left the plating industry in a very delicate position with dark future prospects unless new solutions that are both effective and environmentally friendly are discovered. freeCr6plat is an advanced and demonstrated technology that applies a patented Molecular Self Assembly (SAM) technique for ‘direct metallization’ of a wide variety of plastic surfaces, eliminating the use of Cr (VI) and simplifying the number of steps in the plating process. This allows to reduce the use of chemicals (-30%), rinsing water inputs and wastewater generation and associated treatment (-35%), and energy consumption (-50%), resulting in environmental performance and time (-20%) optimization, while reducing overall plating and wastewater treatment costs by 20% compared to the conventional system. Besides, this technique maintains adhesion promotion within the process, resulting in high quality finishing results comparable to the conventional process. freeCr6plat project aims to reach short term market uptake for automotive applications by adapting the process to automotive plating lines, obtaining specific certifications required by the sector and strengthening our environmental awareness, commercial and netw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Assessing Concepts, systems and tools for a Safer, more Efficient And Lower Operational Cost of the maritime transport of dangerous goods'.

assistant: **Innovation**

The SEALOC project will provide recommendations for the improvement of safety in maritime transport of dangerous goods in Europe, with cost effectiveness analysis. To achieve this result, SEALOC will rely on three case studies using the FSA methodology.The main objectives are : 1) analyse and quantify consequences of one of the best known accidents, the Amoco Cadizaccident, as far as economical and legislative views are concerned2) evaluate the safety issues in the Mediterranean Sea in the case of LPG transport3) evaluate the safety issues in the North Sea in the case of container transport4) assess safety gaps in current operations , rules and procedures5) propose recommendations such as information and communication conceptsLinks with other projects, tasks, areas, programmes, policy actions:potential links with : IMO policies ; MARIS initiative ; POSEIDON, EIES, GEONET 4D projectsCase studies- the historical case of the Amoco Cadiz accident- transport of LPG in the Mediterranean Sea- transport of containers in the North Sea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bioengineering of human ossicles as advanced in vivo hematopoietic model' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

hOssicle aims at developing miniaturized human bone organs in mice to be used as advanced model of healthy and malignant human hematopoiesis. In Europe, 80 million people are estimated to suffer from blood disorders. When at all existing, treatments are poorly effective: 92 % of new drugs successful in preclinical testing (animals and in vitro culture systems) fail in clinical trials. This urgently calls for the development of superior models, to refine our understanding of human hematopoiesis and better predict patient´ therapy efficacy.My laboratory has developed unique human mesenchymal lines capable of forming “human ossicles” by recapitulation of endochondral ossification -the developmental process of bone formation. These ossicles form subcutaneously in mice and display a similar structure and function to native mouse bones, but rely on human mesenchymal cells reconstituting a complex bone marrow environment specifically supporting the development of human hematopoiesis. hOssicle will offer the unprecedented custom engineering of human bones to understand the functional organization of its hematopoietic compartment. By genetic reprogramming of mesenchymal lines, I aim at controlling the molecular and cellular composition of the ossicles and study the corresponding impact on hematopoietic development. Finally, I envision the engineering of patient-specific ossicles with mesenchymal and leukemic blood cells from the same individual towards recapitulation of the disease setting. This will be a significant breakthrough, by offering the study of malignancy progression and drug-testing in a personalized in vivo context for cancer remission.By combining principles of bone development & tissue engineering, hOssicle proposes an “organ engineering” approach applied to hemat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Qualitative Theory of finite-time and random dynamical systems'.

assistant: **Innovation**

This research project aims at developing the qualitative theory of nonautonomous (i.e. time-dependent, random or control) systems in new directions beyond the traditional setting which are highly relevant in the applied science, but surprisingly almost unexplored.The theory of nonautonomous dynamical systems has experienced a renewed and steadily growing interest in the last twenty years, stimulated also by synergetic effects of disciplines which have developed relatively independent for some time such as topological skew product flows, random dynamical systems, finite-time dynamics, and control systems. The importance of nonautonomous dynamical systems is illustrated by the fact that the technological and economical development of our society has generated the need to deal with very complex systems that require an accurate level of understanding. The crisis of the financial markets and weather phenomena associated to climate change such as El Nino, are examples of dynamical processes with a deep economic impact that require sophisticated models to take nonautonomous influences into account.The main challenge in the study of nonautonomous phenomena is to understand the often very complicated dynamical behaviour both as a scientific and mathematical problem. The central aim of this research project is to develop insights and tools in finite-time and random qualitative theory from a mathematical viewpoint which are relevant and have a potentially high impact on the applied sciences. Building upon my success I had during the graduate years from 2006 to 2009 and postdoc since 2009, the proposal contains the following research directions:(i) Invariant manifold theory of finite-time dynamical systems,(ii) Bifurcation theory of finite-time dynamical systems,(iii) Bifurcation t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Microbial lipids: The three domain ‘lipid divide’ revisited' (MICROLIPIDS) under Horizon 2020.

assistant: **Objectives**

Tremendous progress has been made in the last decade in the genetic characterization of microorganisms, both in culture and in the environment. However, our knowledge of microbial membrane lipids, essential building blocks of the cell, has only marginally improved. This is remarkable since there exists a dichotomy in the distribution of lipids between the three Domains of Life. Diacyl glycerols based on straight-chain fatty acids are produced by bacteria and eukaryotes, whereas archaea synthesize isoprenoidal glycerol ether lipids. From a microbial evolutionary perspectives, this ‘lipid divide’ is enigmatic since it has recently become clear that eukaryotes evolved from the archaea. Preliminary results of my research group show that when novel analytical methodology is used, there is a large hidden diversity in microbial lipid composition that may resolve this fundamental question. Here I propose to systematically characterize prokaryotic intact polar lipids (IPLs) with state-of-the-art analytical techniques based on liquid chromatography and high-resolution mass spectrometry to bring our knowledge of microbial lipids to the next level. To this end, we will characterize (i) 250+ bacterial and archaeal cultures and (ii) 200+ environmental samples for IPLs by HPLC-MS, complemented by full identification of fatty acids and other lipids released after acid hydrolysis of total cells. This approach will be complemented by the characterisation of functional genes for lipid biosynthesis. This will involve both mapping of known genes, based on the analysis of published whole (meta)genome data, as well as the identification of as yet unknown genes in selected groups of prokaryotes. The results are expected to make a fundamental contribution to (i) our understanding of the evoluti