RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multi-layered Security technologies to ensure hyper connected smart cities with Blockchain, BigData, Cloud and IoT' in the context of a Horizon 2020 call.

assistant: **Objectives**

IoT systems today tend to be built around the concept of IoT/cloud convergence, integrating heterogeneous data streams within cloud infrastructures, and thus benefiting from the scalability, performance and capacity of the cloud. This approach is very efficient for some IoT applications such as big data processing problems. However, these architectures promote a centralized data collection and processing approach, which introduces several limitations in terms of supported applications and business models that they enable.The main goal of M-Sec project is to empower IoT stakeholders to develop, deploy and operate novel IoT applications based on a scalable highly decentralized paradigm, which facilitates incentivized peer-to-peer interactions between objects and people. The project will explore semantically interoperable interactions between people/objects according to a given social context, beyond their simple peer-to-peer information exchange and internetworking. Overall, the M-Sec paradigm will enable the introduction and implementation of specific classes of applications and services that are not efficiently supported by state-of-the-art architectures.The M-Sec project will deliver a set of concrete and added value main results:1. M-Sec distributed, self-organized, robust and trusted IoT infrastructure that empowers IoT stakeholders to develop, deploy and operate novel multipurpose IoT applications for smart cities on top of smart objects.2. An open IoT market of applications, data and services that provides the framework upon which objects and people can exchange value and defines the motivation incentives for humans and smart objects to interact.3. A sustainable ecosystem of stakeholders, roles, tools and infrastructures upon which new entrants and other players ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards the clinical implementation of TREM2 Microglia Engineering for treating DementiaS' (TREM2MEDS).

assistant: **Innovation**

TREM2MEDS emerges from the ERC PoC 2022 project TREM2μENGINES (Grant agreement ID: 101069395), which validated the efficacy of a novel treatment for Alzheimer’s Disease (AD) and Nasu-Hakola Disease (NHD) in murine models. A relevant proportion of AD cases and all forms of NHD are caused by pathogenic mutations in the TREM2 gene, which lead to microglia dysfunction contributing to and/or causing the onset and manifestations of AD and NHD. TREM2MEDS approach involves the transplantation of hematopoietic stem/progenitor cells (HSPCs) engineered by lentiviral vectors (LVs) to express robust levels of the Triggering receptor expressed on myeloid cells 2 (TREM2) in their central nervous system (CNS) myeloid/microglial progeny. The engineered cells have shown the ability to reduce and prevent Aβ accumulation, mitigate neuroinflammation and restore physiological scavenging functions in the diseased CNS, benefiting AD and NHD in robust animal models. In TREM2MEDS, we will exploit these findings for transition of the approach from TRL 4 to TRL 5/6 by generating IMPD-enabling data and packages that will allow launching, at project completion, a first-in-human Phase I clinical trial of TREM2-HSPC gene therapy in AD & NHD patients carrying TREM2 hypofunctional variants. The restoration of TREM2 function in microglia, by intervening on key mechanisms contributing to neurodegeneration, has the potential to overcome the limited efficacy of current treatments for AD, which only exert symptomatic but not curative effects. Through this work we will thus bring to clinical testing an approach intended to become the benchmark in the treatment of AD and NHD, and possibly other dementias.


**Keywords:** Neurodegenerative Diseases, Gene Therapy, Neuroinflammation, Hematopoietic Stem Cells, TRE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Portable Optical Spectrum Analyzer for Dense Wavelength Division Multiplexing (DWDM) Systems' under Fifth Framework.

assistant: **Concept**

The purpose of the POSA DWDM project is to develop a new, portable optical spectrum analyzer (POSA), suitable for both field and laboratory conditions for the task of maintaining and trouble-shooting DWDM system's components and networks. The instrument will have specifically designed inputs in order to match the dynamic range of the best optical spectrum analyzers available in the world today. The instrument will also have a higher spectral resolution than any existing portable optical spectrum analyzer and the device will be extremely rugged and compact due to its new and unique optical design. Specially designed software will considerably reduce the number of sampling points required and overall measurement time in addition to improvements concerning data transmission and storage. In addition the instrument will be designed to use low cost high bit-rate fast analogue-to-digital converters.Work description:The work required to achieve the project objectives is divided into 9 technical workpackages and two other workpackages concerning dissemination, implementation and the overall management of the project:- The heart of the POSA is a unique double-beam high-resolution interferometer. To meet the state of the art requirements concerning spectral resolution of DWDM channels 9 25 GHz) and less the optical path difference of the interferometer is to be 11 cm, enabling POSA to achieve a spectral resolution of just 2 GHz. The inter-ferometer is to be very compact to allow complete portability;- The high-resolution interferometer also requires a high dynamic range. In the case of classical Michelson interferometers the dynamic range is somewhat limited, due mainly to the intensity of the maximum centre burst of the interferogram. A new, double-beam interferometer will be dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Promotional Platform for Short Sea Shipping and Intermodality' in the context of a Seventh Framework call.

assistant: **Objectives**

The PROPS project builds on previous EU and national activities undertaken to promote and develop short sea shipping. In particular, PROPS aims to work closely with the Short Sea Promotion Centres (SPCs) to develop a workable and replicable methodology that will enhance their practical promotion activities – in the fields of legislative, technical, and operational actions – and to extend their operations to encompass inter-modal and co-modal transport.   The first step will be to identify, from the SPCs, the best practices aimed at improving the integration of short sea shipping with relevant inland logistics chains. Particular attention will be paid to the linkages of key supply chain stakeholders and the removal of bottlenecks.  This initial activity will be followed by a comprehensive analysis of the core processes that are, or need to be, carried out by SPCs, both individually and via the SPC European Network, to develop and utilise a business networking approach to enhance the current. practical work of the SPCs. One outcome of this activity will be a set of performance indicators and benchmarks, linked to self-assessment tools and training programmes for the SPCs.  Tools will be developed to assist the SPCs improve their performance and their overall integration into European logistics business networks. For instance, an ‘e-booking system integrator’, to improve access to commercial freight booking systems, will be established. Both strategic and tactical support mechanisms will be developed, and learning from past failures will be formalised as a mechanism for improving the work of the SPCs to promote short sea shipping and intermodal transport.   A media campaign, run by a large, professional media company will establish and test the campaign in enhancing role o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'RFID Temperature Logger Label' (TSH2020) under Horizon 2020.

assistant: **Objectives**

Today there are no holistic temperature logger solutions capable of following individual temperature sensitive products from production to consumption. The reasons are mainly costs and lack of efficiency. We are therefore developing a low cost RFID Temperature Logger Label. The lowest price on temperature loggers among competitors today is approximately €20 per unit. We intend to offer our label to the marked for €1.5 per unit at rollout, and €0.75 per unit within two years. This label will become part of our total solution consisting of an online database, mobile apps, and handheld or portal readers with read distance up to several meters. Today temperature data from temperature loggers are mainly manually collected. With wireless read distance up to several meters, it is possible to read logger labels on an entire pallet by passing through a portal with RFID readers installed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Performance Control in Wireless Sensor Networks' (GINSENG).

assistant: **Innovation**

Research on wireless sensor networks (WSNs) is at an early stage and, to date, practical experience with deployment has been very limited. The focus of past research has been on fundamental design issues, especially on optimizing the use of scarce energy resources in battery-powered devices. Published studies show relative comparisons between alternative approaches, but there has been a dearth of research on absolute performance in WSNs. In particular, very little attention has been paid to situations where performance assurances are desirable, especially in regard to timeliness and dependability. However, many future WSN applications such as plant automation, vehicle control or health monitoring will demand a degree of certainty in their ability to respond to external stimuli. This proposal will conduct strategic research that will enable the use of WSNs in industrial environments where performance assurances are critical. Key innovations will be produced to enhance the performance and management of WSNs beyond the current state-of-the-art. Working with industry partners, the viability of the research will be demonstrated and evaluated in a large-scale industrial setting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Music that produces racial inequality? The impact of racist ideas on the conditions of existence of Afro-diasporic musicians in Peru' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Racism permeates the everyday musical practices of Afro-Peruvian musicians, impacting their living conditions across class, gender, and phenotype. Informed by a colonial racist framework, Peruvian musicians, scholars, and aficionados have historically conceptualized Afro-Peruvian musical practices in terms of essentialist connections with Africa and black bodies; racial prejudices; and colonial social hierarchies. Such racialization of Afro-Peruvian musical practices entails that its practitioners must routinely address racist expectations and stereotypes, and the way they do so has material and emotional consequences for them.RACISMUS analyzes how racist ideas about Afro-Peruvian musical practices affect the living conditions of its practitioners, as well as the strategies they employ to resist or mitigate such impacts. Drawing on scholarship in ethnomusicology, historical musicology, and critical race theory, RACISMUS objectives are to produce empirical knowledge about: (a) the historical foundations of racist ideas that currently shape the artistic practice of Afro-Peruvian music; (b) how, in shaping their practice, those racist ideas impact the conditions of existence Afro-Peruvian music practitioners across class, gender, and color in a context of racial inequality and mestizaje; and (c) the agency of Afro-Peruvian music practitioners in addressing those racist ideas and their impact in their practice, including their decision-making processes, strategies, and resources.


**Keywords:** Racism, Race, Peru, Blackness, African diaspora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Non-invasive dynamic neural control by laser-based technology' under Horizon 2020.

assistant: **Concept**

Europe faces an enormous human toll of brain disorders, with an estimated 83 million people affected, and economic costs amounting to approximately €800 billion. Drug treatments for brain disorders prove often less than effective with a lack of selective cell targeting. A failure to develop new drugs has led major Pharmaceutical companies to withdraw from CNS drug development in recent years. Methods such as Transcranial Magnetic Stimulation or Deep Brain Stimulation have displayed some therapeutic efficacy, however they are non-selective and/or invasive. It is therefore clear that with a failure of conventional therapy, a new approach is necessary, and development of new technology.NEUROPA will directly tackle this issue. An ideal treatment would be one where activity in specific implicated neuronal networks could be selectively modulated. To be relevant to human disorders the therapy should enable the long-term modulation of dysfunctional networks. For potential widespread use in patients the intervention and monitoring of effects on network activity should also be non-invasive. NEUROPA will develop a new Phytoptogenetics technology: novel Phytochromes that will enable modulation of expression of specific genes, selectively and non-invasively delivered and targeted to cortical neurons in specific cortico-subcortical loops. Novel compact laser sources and a Diffusing Wave Spectroscopy monitoring system will be developed to enable non-invasive bidirectional control of the phytochromes by two-photon excitation. NEUROPA will achieve in-lab technology validation of long-term network activity modulation and behavioural symptom alleviation in Huntington’s and Alzheimer’s disease mouse models. To achieve this, we have assembled a consortium of phytochrome engineering, gene de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dynamic Complexes and Allosteric Regulation of  Small Molecule Transporters' (EXCHANGE).

assistant: **Innovation**

Solute Carrier (SLC) transporters mediate the translocation of substrates across membranes and after GPCRs represent the second-largest fraction of the human membrane proteome. SLC transporters are critical to cell homeostasis, which is reflected in the fact that more than a quarter is associated with Mendelian disease. Despite a few exceptions, however, they have been under-utilized as drug targets and most of the mechanistic understanding has been derived from bacterial homologues of these medically important proteins. In addition to subtle differences, bacterial homologues will not enable us to establish how the activities of many SLC transporters are allosterically regulated through the binding of accessory factors, e.g., hormones, to their non-membranous globular domains. Understanding the mechanisms by which their activities can be allosterically regulated through these complex and dynamic assembles is critical to human physiology and important for future drug design.Our model system is a family of transporters known as sodium/proton exchangers (NHEs), which exchange sodium for protons across membranes to aid many fundamental processes in the cell. NHEs are important to the cell cycle, cell proliferation, cell migration and vesicle trafficking and are associated with a wide-spectrum of diseases. Their diverse portfolio is connected to the importance of pH homeostasis, and the binding of many different factors to a large, globular cytosolic domain exquisitely regulates them. To date, we have no structural information for any of the NHE’s, functional assays in liposomes are lacking, and many interaction partners are yet to be validated by in vitro studies. Determining the structure, dynamics, and allosteric regulation of NHEs will be an enormous challenge. However,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Bringing Machine Translation for European Languages to the User'.

assistant: **Innovation**

Europe faces a growing economic and societal challenge due to its vast diversity of languages, and machine translation (MT) technology holds promise as a means to address this challenge.  EuroMatrix Plus will<br/>- continue the rapid advance of MT technology, creating example systems for every official EU language, and providing other MT developers with our infrastructure for building statistical translation models,<br/>- continue and broaden the controlled systematic investigation of different approaches and techniques to accellerate the scientific evolution of novel methods, including both selection and crossfertilization.  The aim is to to arrive at scientifically well understood novel combinations of methods that are provenly superior to the state of the art,<br/>- contribute to the growth and competitiveness of the European MT research scene and infrastructure through open evaluations and living community supported surveys of resources, tools, systems and their respective capabilities,<br/>- focus on bringing MT to the users, in addition to focusing on scientific advances.  Because our statistical models are derived from example translations, we can build and exploit a synergistic relationship in which users suggest improvements to the system by post-editing its output, and the system improves itself by learning from user feedback.<br/>EuroMatrix Plus focuses on two types of users: professional translators and translation agencies working for private corporations, administrations, and other organisations, and lay users who create content on a volunteer basis by translating foreign materials into their own languages.  We will investigate how these users can benefit from state of the art in MT, and conversely, how MT can benefit from user corrections, and create an o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Competitiveness increase through automated testing' (CITRATE).

assistant: **Innovation**

Software products require constant improvements, due to a rapid change of needs by the users. Successive releases of the products are delivered to the clients, requiring a great amount of time and effort for testing. The costs associated with this activity move forward the break even point of each individual product. This is a common business concern and the main driver of this experiment, whose objective is to reduce total production effort, to reduce errors and to reduce maintenance resources.THE EXPERIMENTThe CITRATE PIE will introduce methods and tools for automated testing, in the software development process of NOVABASE, in a stepwise and continuous way. The total duration of the experiment will be 18 months, starting in March, 1997.The baseline project associated with the CITRATE PIE will be the development and upgrade of the CSI software product line, in the areas of materials management and act management, which constitutes an integrated offer for health care providers.The testing effort, the number of errors and the maintenance costs will be compared along the experiment, against current metrics of the company.NOVABASE employs 80 people, 10 of them involved in the baseline project.EXPECTED IMPACT AND EXPERIENCEAchieving the above objectives represents direct cost savings and an increase on the quality of the products. Higher margins will be obtained and increased competitiveness will be acquired.NOVABASE expects the following impact:To limit the effort needed to test a software product to 10% of the global effort in software production.To reduce by 50% the total number of errors found after product release, leading to a higher quality level and a considerable reduction of risk in the implementation phase.To reduce by 50% the effort needed for client support, t