RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Blood regeneration: de novo development of human hematopoietic stem cells'.

assistant: **Innovation**

Hematopoietic stem cells (HSC) are used in clinical therapies for leukemia and blood-related genetic disorders. Whereasthe number of patients requiring treatment continues to increase, HSC transplantations are limited due to insufficientpatient-matched donor HSCs. The current challenge is to create more matched HSCs. As evidenced by the Nobel Prizeaward this year, reprogramming of somatic cells to pluripotent stem cells (iPS) is one of the most important breakthroughsof recent times. This innovative advance contributes to our ability to reprogram patient-specific cells not only to pluripotency, but also to directly program them to other desired cell lineages. The study of healthy and diseased patient cells in this context will have huge impact on the development of new drug and cell-based treatments. My research is uniquely positioned at the interface of fundamental and translational research at the University of Edinburgh Centre for Inflammation Research and Centre for Regenerative Medicine. Through more than a decade of HSC developmental research, my group has shown that HSCs arise from endothelial cells in a natural reprogramming event. We are one of the few groups worldwide that can isolate these special endothelial cells and show that they yield robust transplantable HSCs (the gold-standard for clinically relevant HSCs). Using our unique expertise I aim to foster new translational strategies to de novo generate human HSCs from patient somatic cells. My aims are to 1) mark and manipulate the program for HSC generation during the endothelial to HSC transition (EHT); 2) define extrinsic molecules affecting EHT and engineer novel niches; 3) reprogram human somatic cells or endothelial derived iPS cells directly to HSCs. These aims will be realized through novel multi-c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Horizon 2020 to Innovation Fund: up-scaling H2020 projects in the Energy Storage and Hydrogen sectors to the Innovation Fund'.

assistant: **Objectives**

The  aim  of  this  proposal  is  to  promote  and  facilitate  technologically, financially,  and operationally  mature  projects  from  Horizon  2020  to  reach  deployment  phase  by  means  of developing synergies with the ETS Innovation Fund.The overall objective of H2IF is to validate such connection could be effective between promising Horizon funded R&I results and Innovation Fund for hydrogen and energy storage projects. This proof of concept will be made thanks to the scaling-up and submission of 3 projects to the Innovation Fund instrument, all of them having been selected due to their high ‘climate neutrality’ potential, their innovation degree, while already being supported by Horizon 2020.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strategic Use of Competitiveness towards Consolidating the Economic Sustainability of the european Seafood sector' (SUCCESS).

assistant: **Concept**

SUCCESS is bringing together an integrated team of scientists from all fields of fisheries and aquaculture science with industry partners and key stakeholders to work on solutions which shall improve the competitiveness of the European fisheries and aquaculture sector. The supply-side of seafood markets is limited from both sea fisheries and aquaculture. At the same time demand for seafood products is increasing. In a globalised economy, the conjunction of these two trends should generate high opportunities for any seafood production activity. However, both fisheries and aquaculture companies are facing key challenges, which currently hinder them reaping the full benefits of seafood markets expansion, and even question their sustainability. As a whole, the EU fisheries sector remains at low levels of profitability and sustainability. The SUCCESS project will examine two strategies to improve the competitiveness of the sector: (i) increasing demand for EU seafood products, especially improving the awareness of the advantages of European production (including sustainability requirements and adjustment to market evolution); and (ii) cost reduction in certain production segments. For both strategies development on world markets as well as consumer preferences and awareness will be analysed. Additionally, SUCCESS will explore the different sectors along the value chain (from fisheries and aquaculture producers via processing companies, wholesalers, retailers to direct marketing to mobile fishmongers and restaurants) and their potential for improvements in competitiveness. These analyses also include long term predictions about the viability of certain production systems and will be considered in specific case studies on for example mussel production, shrimp fisheries, whitef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Democracies in the Climate Crisis: Redefining Citizenship and Statehood in Sinking States' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

RESIST will be the first research to redefine our current legal categories of citizenship and statehood in the extreme case of sea level rise submerging the whole territory of a state. The international community has no experience in managing the disappearance of whole territorial states as a result of environmental disruptions, nor has it designed international legal norms to account for such an eventuality. In this view, RESIST first examines a real-world case, namely the unique case study of Tuvalu, where recent constitutional amendments (2023) have innovated the notion of statehood in light of the impacts of climate change or other causes resulting in loss to its physical territory. More specifically, Tuvalu is the first State to introduce a novel definition of statehood in its Constitution that does not require physical territory as a necessary condition for being recognized as an independent state. Second, it shows the shortcomings of these current legal categories in tackling present and future challenges deriving from the climate crisis and climate-induced migration in particular.Third, it develops alternative and/or broader understandings of citizenship and statehood to better cope with these challenges.Finally,it formulates policy recommendations for how to address the challenge of climate-induced migration of whole states and states that lose a significant part of their territory in a fair manner. The main goal of RESIST is to equip democracies with new conceptual and legal instruments to prevent climate emergencies from being tackled in a way that violates basic human rights. Such a goal is achieved through the following methodology: literature review and legal mapping exercise conducted through the research desk over open-access documents, collection of fur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A multi-stakeholder co-creation platform for better access to long-term care services'.

assistant: **Innovation**

SoCaTel will cater to the needs of the growing ageing populations in Europe by overall improving the accessibility, responsiveness, efficiency and transparency of social and care services, focusing on long-term care. SoCaTel will create, implement and pilot a multi-module/multi-stakeholder platform, which fosters ageing-in- place in a friendly environment and community. This platform, based on past project results such as OASIS and its open government platform Ozwillo, will facilitate end-users’ free choice of government and non-government long-term care services according to their needs, and will empower citizens’ voices and their representatives to champion their causes. Users, public services and innovators will collaborate throughout the process, from design through to development and testing, and onto implementation – facilitating the co-creation of novel services to address emerging needs and opportunities, while encouraging bottom-up innovation. SoCaTel will use governmental and private data sources, via links to platforms such as UniversAAL and PERLIS elderly supervision system, thus also creating additional business opportunities.The SoCaTel approach and platform will be piloted in 4 countries, involving service users, government authorities, universities and the private sector: Spain, Finland, Hungary and Ireland, thus covering different welfare state models and addressing different challenges and cultural settings. SoCaTel puts forward solid frameworks for co-creation, impact assessment, ethics and change management, promoting a smooth introduction of co-creation approaches into public administration. The outputs of the project will be a range of services co-created during the pilots and ready to be deployed. The SoCaTel technological platform will be release
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Role of arbuscular mycorrhizal fungi on the accumulation of radiocaesium by plants'.

assistant: **Concept**

Soils contaminated with Cs pose a long-term radiation hazard to human health. Indeed, the chemical similarity of Cs and K constitutes the major threat to the contamination of the above-ground vegetation and incorporation in the food-chain as root uptake mechanisms appear closely related for these elements. Rhizospheric processes involving soil micro-organisms are known to influence radiocaesium root uptake. Among these, the obligate arbuscular mycorrhizal (AM) fungal symbionts are expected to play a key role due to their intimate position at soil/root interface.Recently, the role of AM fungi in Cs transport to the roots has been evidenced. Furthermore, it has been demonstrated that AM fungi can influence Cs root to shoot translocation by affecting Cs root transport. A recent hypothesis attributed to abscisic acid a primary role in restricting this transport. With this in view, the objective of the present proposal is to elucidate the mechanisms involved in the transport of Cs by AM fungi to the root and translocation from roots to shoot, leading to the evaluation of the radioecological significance of AM fungi on the accumulation of Cs in plants and to propose implementations of present bioremediation strategies. To achieve this goal five major fields of training, i.e. microbiology, molecular biology, biophysics, plant physiology and radioecology, will be considered.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Training Alliance for Computational Systems chemistry' to be submitted under Horizon Europe.

assistant: **Abstract**

Many important questions and grand challenges in research, industry, and society involve large and complex networks of chemical reactions. Some examples are: studying metabolic networks in humans; planning and optimizing chemical synthesis in industry and research labs; modeling the  fragmentation process in mass spectrometry; developing personalized medicine; probing hypotheses of the origins of life; monitoring environmental pollution in air, water, and soil.In project TACsy, we will develop ground-breaking new computational methods for analyzing such networks of chemical reactions and we will train a new generation of excellent and innovative early stage researchers (ESRs) capable of evolving and applying these methods in research and industry. Combined, these efforts carry very strong potential for impact on the grand challenges mentioned above, on the EU commission priority on jobs, growth, investment, and competitiveness, and on the  well-being of EU citizens.The research methodology of TACsy arises from the novel application of formalisms, algorithms, and computational methods from computer science to questions in systems chemistry. The first steps demonstrating the strong capabilities of this approach have recently been made. In TACsy, the ESRs will vastly expand these methods and their formal foundations, they will create efficient  algorithms and implementations of them, and they will use these implementations for research in  complex chemical systems in three flagship application areas. TACsy is a consortium of world-class, experienced scientists which will ensure excellent research training conditions for the ESRs in this highly interdisciplinary field. Through a carefully  designed training programme and secondments at leading industry partners, the ESR wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'TRANSLATION OF DOMESTICATION OF THUNNUS THYNNUS INTO AN INNOVATIVE COMMERCIAL APPLICATION' to be submitted under Seventh Framework.

assistant: **Abstract**

Due to declining stocks and increased fishing pressure there are serious concerns that the present fisheries and fattening industry for Bluefin Tuna (Thunnus thynnus) is not sustainable and that every effort should be made to develop BFT aquaculture. TRANSDOTT represents a “top-down” approach from one Enterprise, four SME´s and three non SME´s to build on the scientific results obtained from two previous projects REPRODOTT in (FP5)  and SELFDOTT (FP7) and to translate them  into a commercially viable innovative marketable application for tuna aquaculture. Starting in April 2012, based on an already established broodstock in a  central Mediterranean major SME in Malta, fertilized tuna eggs will be provided in June 2012 and 2013  for larval rearing in three industrial scale hatchery SME´s  for rearing scenarios in Spain, Israel and Italy together with two experimental hatcheries in Malta and Israel.  RTD will involve the validation of existing protocols with the generation of fingerlings in late summer to be transferred from the industrial hatcheries to grow- out sea cages. Previously tried and tested, successful weaning and grow-out diets from SELFDOTT will be supplied by the Enterprise partner. The economic viability of these methodologies will be studied and used for the development of commercialization and capitalization of this process to provide sustainable Tuna Aquaculture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Information Processing in PULSEd P Environments: Comparison of adaptive phosphorous uptake and the competitive abilities between bloom forming diatoms and the coccolithophore Emiliania huxleyi' in the context of a Sixth Framework call.

assistant: **Objectives**

To date, research on adaptation of photosynthetic microorganisms to external stimuli such as nutrients and light has mainly focussed on full adaptation. The aim of this study is to understand the largely unknown constrains that determine the transition fro m one adaptive state to another. This is not a time invariant phenomenon, but proceeds in a historical context in that every adaptation is determined by previous adaptation of an organism. In this respect the cellular memory will be studied as response to a sequence pattern of phosphorus pulses varying in amplitude and frequency. The 32P-uptake experiments focus on the ecophysiological relevance of information processing in a P-pulsed environment. From this view, the P-uptake will be described phenomenologically as in thermodynamics.P is favoured because it can limit both marine and freshwater algal growth and plays a central role in metabolic pathways. In the past, nutrients as P have often been treated as slowly varying in ecological studies. However, we know that P is often supplied in pulses when microscopic animals or fish excrete, or when storms mix P-rich deeper waters into P-poor surface waters. A key issue here is, to gain a better understanding how the adaptive uptake of P-pulses interact with the utilisation of light and other nutrients. The P-light-interactions will be analysed by photosynthetic properties of contrasting states, the `adapted state and the `non-adapted (adaptive) mode.The study of cellular P-compounds as DNA, RNA and lipids will b e linked to ecological stoichiometry. We will prove the hypothesis that distinct P-uptake strategists confirm a recently discussed concept of ecological strategists. Practical issues are to develop field bioassays determining the P-availability in marine systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Identifying spatial determinants of immune cell fate commitment'.

assistant: **Objectives**

The complex architecture of the mammalian hematopoietic system has been studied for decades, yet the molecular mechanisms underlying cell fate commitment remain poorly understood. Although cytokine signals are major determinants of hematopoietic cell fate, only few niches of stem and progenitor cells have been characterized. Here, we propose to resolve the cell type composition of mouse bone marrow by integrating single-cell RNA-seq with high-resolution spatial analysis of gene expression in tissue sections, visualizing ~250 cell type specific markers by multiplexed single-molecule RNA fluorescent in situ hybridization. This approach will reveal preferential co-localization of hematopoietic cells with other bone marrow-resident cell types, and globally predict niches of hematopoietic progenitor sub-types to pinpoint microenvrionmental determinants of hematopoietic cell fate. Based on this reference we will investigate the role of the microenvironment in the pathogenesis of myelodysplastic syndromes (MDS), representing one of the most frequent blood cell malignancies, commonly giving rise to leukaemia with poor prognosis. To investigate conservation of microenvironmental determinants of normal and malignant hematopoietic differentiation in human, we will apply the same strategy to healthy donors and human MDS patients and compare predicted cell types, differentiation trajectories, and niche interactions to those derived from healthy mice and murine MDS models. This approach will reveal conserved niche regulators of cell fate commitment involved in disease pathogenesis, which we will functionally analyse in murine models to identify novel therapeutic targets for prevention and treatment of MDS. Our approach represents a blueprint for investigating human malignancies of un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cognitive Analysis and Statistical Methods for Advanced Computer Aided Translation' (CASMACAT).

assistant: **Concept**

The CASMACAT project will build the next generation translator's workbench to improve productivity, quality, and work practices in the translation industry.<br/>We will carry out cognitive studies of actual unaltered translator behaviour based on key logging and eye tracking. The acquired data will be examined for how interfaces with enriched information are used, to determine translator types and styles, and to build a cognitive model of the translation process.<br/>Based on insights gained in the cognitive studies, we will developnovel types of assistance to human translators and integrate them intoa new workbench, consisting of an editor, a server, and analysis andvisualisation tools. The workbench will be designed in a modular fashion and can be combined with existing computer aided translation tools.<br/>We will develop new types of assistance along the following lines:(1) Interactive translation prediction, where the workbench makes suggestions to the human translator how to complete the translation. We will adapt the existing interactive machine translation paradigm by adding input modalities, especially electronic pens and basing the suggestions on better exploitation of novel statistical machine translation models.(2) Interactive editing, where the workbench provides additional information about the confidence of its assistance, integrates translation memories, and assists authoring and reviewing.(3) Adaptive translation models, where the workbench learns from the interaction with the human translator by updating and adapting its models instantly based on the translation choices of the user.<br/>We will demonstrate the workbench's effectiveness in extensive field tests at a translation agency. In addition, we will also reach out to the wider language service in