RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reconstructing 200 years of genetic history in European wolves' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Wolves are an important apex predator species, and their conservation in Europe has been a key concern since their population collapse at the beginning of the 20th century. Increases of wolf population numbers in recent decades provides a positive sign for the viability of this species moving forward, but has also led to the re-emergence of wolf-human conflicts. Thus, maintaining the genetic health and biodiversity of this important natural predator species, whilst minimizing such conflicts remains critical across Europe.  In this project, I will investigate the population dynamics and changing genetic makeup of European wolves over the past 200 years. By utilizing a comprehensive next-generation-sequence database of modern (n=927) and historical (n=586) genomes, I aim to implement complex, state-of-the-art analyses to model the fine-scale demographic history, genetic health and dog introgression of European wolves in recent times. By working at the cross section of population genomics, ancient DNA and conservation, this project will provide critical insights into the effects of recent population history events on the genetic makeup of this important predator species.  Broad dissemination of the findings of this project to the scientific community, conservation groups and the general public will directly assist in designing targeted management strategies to preserve the biodiversity of European wolves moving into the future. By utilizing one of the largest genomic datasets for a wild animal species to date, the novel methodologies applied in this project will provide a blueprint for future conservation genetics studies in other species.


**Keywords:** Computational biology, imputation, European wolves, ancient DNA, demographic history reconstruction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'High power tunable semiconductor laser diode research'.

assistant: **Innovation**

Researeh objectives and content The research objectives are to train a post-doctoral fellow in high brightness, high power laser technology by developing new high brightness, high power tunable laser diode sources for application in teleeommunieations and industnal process monitoring areras, The research project will entail both laser diode design and characterisation, and novel external cavity research and development for enhanced wavelength tunabilitylmla emission power and brightness. The utility of the developed i, laser will be assessed by demonstrating enviromnental monitoring and blue light generation by frequency doubling. | Training content (objective, benefit and expected impact) This proposed objective is to train the candidate in the technology of high power laser diode system development. It will benefit from the growing communications and industrial process control business sectors. The project will impact the sectors by the prevision both of a highly trained technologist and new technology in tunable laser systems. Links with industry / industrial relevance (22) This project is strategic to European industrial competitiveness in optical communications and industrial process control. The training laboratory has strong ongoing links with industries in these technology access which will lead to rapid deployment of the developed technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Rescuing Cognitive Deficits in Neurodevelopmental Disorders by Gene Editing in Brain Development: the Case of Down Syndrome' in the context of a Horizon 2020 call.

assistant: **Objectives**

Neurodevelopmental disorders (ND) are chronic psychiatric conditions with different etiologies, but most share a strong genetic component, defective brain development, and cognitive impairment. Currently, treatment options are very limited, and early educational intervention is the cornerstone for the management of cognitive impairment in most ND, indicating the positive effect of early actions during brain development. Among ND, Down syndrome (DS) is caused by the presence of an extra chromosome 21, and it represents the leading cause of genetically-defined intellectual disability. Different pharmacological treatments targeting one of the many pathways downstream of the triplicated genes have been shown to rescue cognitive impairment in DS animal models. Nevertheless, most of these preclinical studies have been performed postnatally and often in adults, possibly because of concerns of unwanted drug side effects that may have long-lasting noxious sequelae on a developing brain at embryonic stages. On the other hand, viral (but also non-viral) gene therapy approaches in animal models of ND have been mostly neglected because of technical and ethical issues, when considered in the light of future translational applications. Yet, DS is mostly diagnosed prenatally, when many of its brain developmental abnormalities originate. Here, we will investigate whether in utero manipulation of specific and possibly converging gene networks in neuronal progenitors of DS mice by CRISPR-Cas9 gene-editing technology, may recover brain development and cognitive deficits later in life. Specifically targeting neuronal progenitors will allow us to act at early stages of brain development, while avoiding the involvement of genetic editing of germline cells and all related ethical issues. In pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Data-based analysis for SAFETY and security protection FOR detection, prevention, mitigation and response in trans-modal metro and RAILway networkS' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Railways and Metros are safe, efficient, reliable and environmentally friendly mass carriers, and they are becoming even more important means of transportation given the need to address climate change. However, being such critical infrastructures turns metro and railway operators as well as related intermodal transport operators into attractive targets for cyber and/or physical attacks. The SAFETY4RAILS project delivers methods and systems to increase the safety and recovery of track-based inter-city railway and intra-city metro transportation. It addresses both cyber-only attacks (such as impact from WannaCry infections), physical-only attacks (such as the Madrid commuter trains bombing in 2014) and combined cyber-physical attacks, which are important emerging scenarios given increasing IoT infrastructure integration. SAFETY4RAILS concentrates on rush hour rail transport scenarios where many passengers are using metros and railways to commute to work or attend mass events (e.g. large multi-venue sporting events such as the Olympics). When an incident occurs during heavy usage, metro and railway operators must consider many aspects to ensure passenger safety and security, e.g. carry out a threat analysis, maintain situation awareness, establish crisis communication and response, and they have to ensure that mitigation steps are taken and communicated to travellers and other users. SAFETY4RAILS will improve the handling of such events through a holistic approach.  It will analyse the cyber-physical resilience of metro and railway systems and deliver mitigation strategies for an efficient response, and, in order to remain secure given ever-changing novel emerging risks, it will facilitate continuous adaptation of the SAFETY4RAILS solution; this will be validated by two ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Electroweak Phase Transition Beyond the Standard Model'.

assistant: **Innovation**

The observed asymmetry between matter and antimatter in the Universe is direct evidence that the Standard Model of particle physics, recently completed through the discovery of the Higgs boson, does not account for all (non-gravitational) physical phenomena. Although all the ingredients required to explain the asymmetry from fundamental interactions are present within the Standard Model, a comprehensive effort to reproduce the observed magnitude has sofar failed.In particular, the process by which the asymmetry is created must be strongly out of thermal equilibrium, and this cannot be provided by the electroweak phase transition, as was originally expected. This follows directly from the value of the Higgs boson mass, observed to be 125-126 GeV at the LHC at CERN, and was established in a seminal paper by Kajantie et al. (1996).The natural next step is to investigate what minimal extensions of the Standard Model can lead to a strong electroweak transition; what is the transition temperature and dynamics of the transition; and how do the resulting constraints on these theoretical extensions compare with the steadily improving experimental constraints from collider experiments.I propose to use state-of-the-art numerical lattice simulations to answer these questions. Because the computation involves non-perturbative and/or out-of-equilibrium phenomena, analytic methods can only take us so far. Complementing known results with numerics will allow me to establish whether a number of extension of the Standard Model may account for the observed asymmetry, and what predictions this infers for collider experiments; and I will simulate the dynamics of a strongly first order phase transition, the nucleation of vacuum bubbles and interaction with a thermal plasma.The fellowship wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'ETVAX – the first oral vaccine for protection against traveller’s diarrhoea caused by ETEC'.

assistant: **Concept**

This project will perform a Phase II study of ETVAX – an oral vaccine against traveller’s diarrhoea (TD) caused by enterotoxigenic E. coli bacteria (ETEC). ETVAX has a strong potential to be the first vaccine with a full ETEC indication. TD caused by enterotoxigenic E. coli bacteria is the most common illness that affects travellers traveling in the developingregions. Currently, there is no approved method for preventing TD.Travellers are recommended to use off-label antibiotics such as Rifaximin or the cholera vaccine Dukoral to prevent TD. In business terms, there exists a strong business opportunity in developing and commercializing an effective and safe ETEC vaccine. Scandinavian Biopharma is the first SME positioned to capture this opportunity. The envisaged Phase II study willallow Scandinavian Biopharma take the key step towards the commercialization of ETVAX.The targeted users of are travellers visiting tropical and subtropical countries. Their number is forecasted to reach 190 million by 2020. Their key need is to prevent TD which can ruin a significant part of a vacation or a business trip. ETVAX will meet this needs by being safe, efficient and easy to use.The project delivers an ultimate EU added value by offering the first ETEC vaccine with proven immunogenicity, safety and efficacy. From the scientific perspective, this means that the project fills the gap in the vaccine research on the EU and global level as no other efficient methods for prevention of TD have been proposed on the market to date. The introduction of ETVAX will ultimately decrease number of TD cases among travellers, decrease number of patients with irritable bowel syndrome or other chronic diseases connected to TD, as well as decrease healthcare costs and productivity losses on the EU lev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multipurpose Aircraft Simulation Laboratory' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The tendency of the past to build and test in aeronautics has clearly been overridden by a very extensive simulation activity for many reasons, one of these being the risk associated to safety-critical or safety-related systems. Simulation in hence strategic to develop and test all the key aircraft elements, such as flight control systems, and is now being used effectively also beyond the design purposes, to conceive and evaluate mission strategies, for example, Humane-Machine-Interfaces or operational procedures. During the last decade, many commercial simulation environments and advanced software codes have been released and made available to research centers and industrial entities, which now share very powerful and versatile simulation tools. It is now possible to simulate very complex multi-variable multi-dynamic non linear aircraft systems in real time on a single personal computer. There are tools for testing, verification and validation of the related flight control systems and for automatic generation of executable codes, which comply with the main avionic standards (such as the DO-178B). The proposer research group has been using effectively all these tools extensively to develop flight simulators for rotary and fixed wing manned aircrafts as well as for lighter-than-air unmanned platforms. The group has developed a strong competence in all the activities related to interpretative dynamic simulation, advance control system design, software stress analysis, I/O interface setting and testing, as well as real-time validation. Moreover the group is now sustaining an extensive effort in developing a Matlab/Simulink framework for multi-purpose activities such as system and subsystem design, but also model-base reliability and safety analysis. All these technical com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unravelling mechanisms controlling asperities synchronization and triggering mega-earthquakes: insights from analog experiments and subduction zone earthquake statistics' in the context of a Horizon 2020 call.

assistant: **Objectives**

Subduction mega-earthquakes are among the most destructive events on Earth. When affecting very densely populated areas these earthquakes may cause extensive human losses and severe damages, as for the 2011 M9.0 Tohoku-Oki event (Japan). According to the ‘asperity model’, a mega-earthquake may occur when regions of the fault that are potentially seismic (i.e., asperities) interact and synchronize failing together. But understanding the physical conditions that are responsible for such synchronization still remains enigmatic. AspSync proposes to tackle this problem using a multidisciplinary approach that combines analog modelling with geodynamics and statistics.AspSync proposes to develop a 3D mechanical prototype that reproduces the convergent margin features, including interplate earthquakes. This model will  feature laterally (i.e., in trench parallel direction) heterogeneous frictional behavior mimicking the asperities that characterize the plate interface. Tuning the physical and frictional properties of asperities, AspSync will systematically test the role of their dimensions, distance, geometry and strength in the synchronization process, unlocking the possibility to infer the physical conditions that lead to the triggering of mega-earthquakes.AspSync will then link the experimental results with ‘real Earth conditions’, studying the feedbacks between geodynamical properties of convergent margins and interplate seismicity aiming to identify the physical conditions that promote mega-earthquakes triggering. AspSync will update and analyze the existing database of global physical properties of subduction zones and interplate seismicity developed at UM2 applying robust statistics (e.g., multi-parametric pattern recognition analysis; analysis of temporal series) to quan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cardiac Connective Tissue: Beat-by-Beat Relevance for Heart Function in Health and Disease' (CARDIONECT).

assistant: **Innovation**

Cardiac connective tissue is regarded as passive in terms of cardiac electro-mechanics. However, recent evidence confirms that fibroblasts interact directly with cardiac muscle cells in a way that is likely to affect their beat-by-beat activity.To overcome limitations of traditional approaches to exploring these interactions in native tissue, we will build and explore murine models that express functional reporters (membrane potential, Vm; calcium concentration, [Ca2+]i) in fibroblasts, to identify how they are functionally integrated in native heart (myocyte => fibroblast effects). Next, we will express light-gated ion channels in murine fibroblast, to selectively interfere with their Vm (fibroblast => myocyte effects). Fibroblast-specific observation and interference will be conducted in normal and pathologically remodelled tissue, to characterise fibroblast relevance for heart function in health & disease.Based on these studies, we will generate 2 transgenic rabbits (fibroblast Vm reporting / interfering). Rabbit cardiac structure-function is more amenable to translational work, e.g. to study fibroblast involvement in normal origin & spread of excitation across the heart, in pathological settings such as arrhythmogenicity of post-infarct scars (a leading causes of sudden death), or as a determinant of therapeutic outcomes such as in healing of atrial ablation lines (interfering with a key interventions to treat atrial fibrillation).The final ‘blue-skies’ study will assess whether modulation of cardiac activity, from ‘tuning’ of biological pacemaker rates to ‘unpinning’ / termination of re-entrant excitation waves, can be achieved by targeting not myocytes, but fibroblasts.The study integrates basic-science-driven discovery research into mechanisms and dynamics of bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Attracting and Encouraging Triple I Talent Mobility' under Horizon 2020.

assistant: **Concept**

Athenea3I is an innovative regional wake-up call focused on attracting highly talented researchers to Granada (Andalusia region, Spain) in order to benefit their research career with International, Interdisciplinary and Intersectorial opportunities. This innovative fellowship programme offers the experienced researchers an outstanding opportunity to develop new skills and competences, enriched with a personalized and pioneering career mentoring plan. It also includes research periods at some of the most distinguished outstanding institutions around the world, and optional secondments in regional, national and international companies.The high-talented human capital hired by the University of Granada, as beneficiary institution, will perform as active “magnets” in relation not only to academy, but to industry and business, establishing bridges for transfer of knowledge, exploitation of the results, and future research collaborations. Athenea3I commitment pivots on the applicability of the research outputs by making Science for Society: reinforcing not only the innovation aspect but also the open data access and the public engagement. It has on target the social challenges of Andalucia2020, shooting up their results to palliate some socio-economic problems of the region and, consequently, to get towards the Europe2020 targets.


**Keywords:** Triple I, Talent Mobility, Networking, ER Mentoring, Research Carreer Development, Innovation, Regional weak-up call