RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Removing hazardous substances to increase recycling rates of WEEE, ELV and CDW plastics'.

assistant: **Objectives**

The overall objective of NONTOX is to increase the recycling rates of plastics waste containing hazardous substances by developing and optimising recycling processes to produce safe and high quality secondary plastic materials and by optimising the overall process economics by integration. Increasing recycling rates is crucial for the implementation of a circular economy as clearly stated in the EU Plastic Strategy. NONTOX focuses on the removal of hazardous and undesired substances from plastic waste taking into account the whole value chain: sorting and pre-treatment techniques, recycling technologies but also post-treatment techniques. Valorisation of by-products and removed substances is also considered to enhance potential applications. NONTOX will target material recovery of plastics originating from WEEE, ELV and C&DW streams containing hazardous additives or undesired compounds such as flame-retardants, stabilizers, fillers,  etc. Main secondary plastic outputs will include for example, ABS, EPS, PS, HIPS, PE, PP. The market for these polymers is massive as together they represent about half of the EU demand for plastics and yet a significant portion of these valuable plastics is landfilled or incinerated. NONTOX will further develop two different technologies (Extruclean and CreaSolv®) to remove hazardous substances from aforementioned plastic waste streams, allowing for increased recycling rates. NONTOX will also improve knowledge and state of the art concerning pre-treatment and sorting of plastic waste containing hazardous substances. Thermochemical conversion of non-target plastics and side streams from the main recycling processes will be investigated to increase system efficiency by integration and widen the range of final products and applications. NONTO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Holistic solution to improve animal food production through deconstructing the biomolecular interactions between feed, gut microorganisms and animals in relation to performance parameters' (HoloFood) targeting Horizon 2020.

assistant: **Abstract**

Optimising food production is not only of commercial interest for companies, but with the planet’s population approaching the nine billion mark, also of critical importance for humanity. Animal food production can be optimised by modulating animal-associated microbiomes through the use of feed additives such as prebiotics and probiotics. Previously developed feed additives have not acknowledged the specific means of action of the additives on the microbiome and host organisms, and consequently i) their performance is inconsistent across animals with different genetic background and when grown under different environments, ii) improvement of feed additives is inefficient and costly, and iii) optimal solutions are unlikely to be found without taking a more holistic approach. HoloFood showcases a holistic approach that will improve the efficiency of food production systems by deciphering the molecular and physiological processes triggered by feed additives across animals with different genetic background and grown under different environments. We will use two critically important farmed animal systems as our models -salmon and chicken- and characterise not only their associated microorganisms’ genomes, transcriptomes and metabolomes but also how the microbiome interacts with animals' genomes and transcriptomes within the new holo-omic framework in relation to key performance indices and animal welfare issues. The knowledge generated will be used to optimise feed additive administration strategies of already implemented products by tailoring them to the genetic background and developmental stage of the animals as well as production environment, to improve the quantity, quality and safety of the produced food, as well as sustainability of food production and animal welfare.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Canadian European Research Initiative On Nanostructures - 2' (CERION-2) under Fifth Framework.

assistant: **Objectives**

Nano-technology is one of the most promising and enabling technologies. The rapid increase in cost for performing state-of-the-art research in nano-technology and multidisciplinary dimension necessitates that international resources, facilities and expertise are pooled. This Working Group (WG) aims to develop and strengthen collaborations between Europe and Canada in the area of nano-technology. Cerion-2 builds on the successful Cerion WG. The collaborations are designed to benefit from the complementary facilities, techniques and expertise of the partners. A new dimension of CERION-2 is its emphasis on the multidisciplinary nature of nano-technology expected to promote cross fertilisation of ideas and concepts. Topics such as semiconductor spintronics and quantum information are accompanied by approaches involving biological and polymer nano-structures. Nano-technology is one of the most promising and enabling technologies. The rapid increase in cost for performing state-of-the-art research in nano-technology and multidisciplinary dimension necessitates that international resources, facilities and expertise are pooled. This Working Group (WG) aims to develop and strengthen collaborations between Europe and Canada in the area of nano-technology. Cerion-2 builds on the successful Cerion WG. The collaborations are designed to benefit from the complementary facilities, techniques and expertise of the partners. A new dimension of CERION-2 is its emphasis on the multidisciplinary nature of nano-technology expected to promote cross fertilisation of ideas and concepts. Topics such as semiconductor spintronics and quantum information are accompanied by approaches involving biological and polymer nano-structures.OBJECTIVESThe CERION-2 Working Group will consist of a European-Can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of MRI contrast agents based on long-lived singlet states' (SingMet) targeting Horizon 2020.

assistant: **Abstract**

The goal of the project is the development of new contrast agents for magnetic resonance imaging (MRI) based on the concepts of hyperpolarization and singlet state nuclear magnetic resonance (NMR). Hyperpolarization boosts the detectable NMR signal of the contrast agents by up to 4 orders magnitude and the generation of singlet states conserves the enhanced polarization for a long time, while not giving a directly detectable signal. The NMR signal can subsequently be obtained by chemically breaking the molecular symmetry or by applying radiofrequency pulses. This technique therefore allows for the detection of a NMR signal after minutes instead of seconds compared to state-of-the-art metabolic tracers. A combination of these techniques leads to a nanomolar detection limit of the tracers, which is a remarkable sensitivity for MRI. The chemical transformation which triggers the generation of a hyperpolarized NMR signal may be due to enzymes which are diagnostic of cancer cells. The project leads towards new agents for the in vivo detection and imaging of cancer without the use of ionizing radiation or contrast agents containing dangerous heavy metals. Overall it is planned to develop molecules with nanomolar detection limits upon hyperpolarization, that maintain their traceability for minutes and undergo chemical transformation induced by enzymes, which can be tracked utilizing MRI.


**Keywords:** dynamic nuclear polarization, singlet states, hyperpolarization, metabolites, NMR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced Thin-Film Technologies for Cost Effective Photovoltaics' to be submitted under Sixth Framework.

assistant: **Abstract**

Long term scenarios for a sustainable global development suggest that it should be feasible by the middle of this century to provide over 80% of the electric power by a mix of energy from renewable sources. Photovoltaics (PV) is one important option which can provide a significant share of over 30% to such a mix. According to the learning curve for cost reduction of photovoltaics, thin film solar cells will play a major role. The APAS study, assigned by the European Commission, has shown that for large-capa city facilities (> 60 MW/year per plant) the manufacturing costs for thin film modules will become substantially lower, compared to crystalline silicon wafer modules. This project focuses on the most promising material and device options for thin film t echnologies, namely cadmium-free cells and modules, based on amorphous, micro- and polycrystalline silicon as well as on I-III-VI2-chalcopyrite compound semiconductors. The overall goal is to provide the scientific and technological basis for an industrial mass production of cost effective and highly efficient, environmentally sound, large-area thin film solar cells and modules. By drawing on a broad basis of expertise, the entire range of module fabrication and supporting R&D will be covered: Substrate s, semiconductor and contact deposition, monolithic series interconnection, encapsulation, performance evaluation and applications. The main objectives are: - significantly reducing the cost/efficiency ratio: towards 0.5 Euro/Wp on the long run - providing the know-how and the scientific basis for large-area PV modules by identifying and testing new materials and technologies with maximum cost reduction - developing the process know-how and the production technology as well as the design and fabrication of specialised
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of minerals in the oceanic carbon cycle' in the context of a Horizon 2020 call.

assistant: **Objectives**

The oceanic carbon cycle is key for regulating the Earth system because, in sediments and seawater, the balance between the degradation and preservation of organic carbon (OC) exerts a first order control on atmospheric CO2 and O2. In sediments, OC is preserved over millions of years, while in seawater, a dissolved form of recalcitrant OC has been recently recognised as critical to OC storage over anthropogenic timescales. Both sedimentary and seawater OC are derived from living organisms, and should therefore be easily degraded. Their persistence is therefore profoundly puzzling. Quite simply we do not know how or why OC is preserved. A long-standing hypothesis suggests that protection of OC inside minerals might account for the vast OC stores preserved in sediments. In a NEW hypothesis, based on recent work by the PI and proposed here for the first time, the interaction of OC with minerals might ALSO account for the even larger stores of dissolved OC preserved in seawater. Together these concepts could revolutionise our understanding of OC degradation and preservation, but the extent to which minerals preserve OC in sediments and seawater is (still) unknown, largely because the mechanisms that control how OC interacts with minerals are almost entirely unconstrained. MINORG will quantify the role of minerals in the preservation of OC for the first time, by combining cutting-edge molecular-level techniques with the first ever comprehensive and fully integrated experimental and modelling campaign, to determine in unprecedented detail the exact mechanisms responsible for the interaction of OC with minerals, and its subsequent degradation and preservation behaviour. MINORG hypothesises that minerals play a MAJOR role in the preservation of OC, in both its sedimentary and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Technology transfer node Thuringia' (TTN-T), addressing dissemination and exploitation.

assistant: **Impact**

TTN-T is built on three non-profit organisations with complementary tasks and skills in: Image processing and acquisition, production engineering for user support/demonstration, and transfer/project management for broker function. The consort is located in Thuringia and will co-ordinate the European PST action for HPCN application projects with the specific objective to integrate HPCN technologies for fast vision and 'cognitive automation' into manufacturing and processing lines. The activities are focused on real time recognition for complex structures in (ultra)fast processes, so in quality inspection by HPCN embedded systems. TTN-T will also promote R&D projects in HPCN embedded systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Single Molecule Enzymology with ClyA Nanopores' (SMEN).

assistant: **Concept**

Single molecules based techniques provide the ultimate toolkit to study complex biological systems. In single-molecule approaches, molecules do not need to be synchronised as in ensemble studies, and rare and/or transient species along a reaction pathway as well as heterogeneity and disorder in a sample can be revealed.Observing and manipulating single molecules, however, is generally complicated, time consuming and withstand several technical limitations that hamper the study of single enzymes to a few selected examples.Here I am proposing to develop a new technology to study single native enzymes that is sensitive, simple and inexpensive, and has a temporal resolution ranging from few ¼seconds to hours.Nanopores have been used to detect single molecules and to investigate mechanisms of chemical reactions at the single molecule level. The basic concept of nanopore analysis is to observe, under an applied potential, the disruption of the flow of ions through the pore caused by the interaction of the molecules of interest with a binding site within the pore.Similarly, small enzymes or functional nucleic acids will be attached to the vestibule of a biological nanopore via disulfide bridge or click chemistry. The conformational changes associated with catalysis will then be observed by the altered ionic flow through the pore. In addition, when a charged chaotropic agent is placed on the trans side of the bilayer, the applied potential will allow the directional control of the flow of the chaotropic agent through the pore that, ultimately, also will control the unfolding and refolding of the protein attached to the pore. This will allow investigations of reversible unfolding processes far from equilibrium at the single molecule level for the first time.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification and manipulation of factors that control Shigella flexneri entrapment in septin cages.' to be submitted under Horizon 2020.

assistant: **Abstract**

Shigella is a Gram-negative bacterial pathogen and causative agent of bacillary dysentery (also called shigellosis). Shigella kills ∼164 thousand people per year and is recognised by the WHO as a priority pathogen due to the emergence of antibiotic resistant strains. In the laboratory, Shigella is an important model organism used to study cellular microbiology and host response to infection.This proposal will innovate approaches to discover factors underlying the entrapment of Shigella in “septin cages”, a host defence mechanism discovered by Prof. Mostowy. Septins are highly conserved GTP-binding proteins that polymerize into cage-like structures to entrap actively dividing intracellular Shigella, preventing their division and actin-based motility. Here, I will identify and study new host and bacterial factors underlying the formation of septin cages in HeLa cells. For this, I will use a proximity biotinylation assay (split APEX2) specifically localized at sites of Shigella-septin association, followed by mass spectrometry. I will then investigate the identified candidates by siRNA and CRISPR/Cas9 depletion in the case of the host, and by homologous recombination in the case of the bacteria, to monitor the number, morphology and dynamics of septin cages using high-content microscopy. In addition, I will do GFP-fusions to analyse the subcellular localisation of the candidates by high-resolution microscopy. Finally, to control the fate of intracellular Shigella, I will manipulate septin cage formation using nanobodies to artificially deliver septins (and other septin caging factors identified by mass spectrometry) to the surface of Shigella during infection.It is expected that my research will discover fundamental mechanisms underlying the entrapment of Shigella in septi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mip2000' (MIP2000) under Fifth Framework.

assistant: **Objectives**

The transport of water and small osmolytes across biological membranes is of fundamental importance for cellular and organism osmoregulation. MIP channels, i.e aquaporin water channels and glyceroaquaporins, play central roles in water and solute transport in organisms ranging from bacteria to man and constitute a major potential in steering of osmoregulation in medicine, pharmacology and agrobiotechnology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Platforms for biomedical discovery with human ES cells' (ESTOOLS), addressing dissemination and exploitation.

assistant: **Impact**

The pluripotent nature of human embryonic stem (hES) cells presents unprecedented opportunities for studying human cellular differentiation and pathogenesis. Furthermore, hES cells offer a new resource for cellular transplantation in human degenerative disease and a powerful platform for pharmaceutical and toxicology screening. The promise of hES cells rests largely on achieving two things: (i) unlimited expansion in stem cell numbers without genetic or epigenetic compromise; (ii) directing differentiation with absolute phenotypic fidelity. Delivery of these twin objectives entails full understanding of the mechanisms that control the choices between proliferation and self renewal on the one hand, and apoptosis and commitment to differentiation on the other. Genetic intervention will be a central tool in delineating the molecular circuitry of hES cells.The goal of ESTOOLS is to develop and implement the necessary tools to elucidate the genetic and molecular networks that control the self renewal, commitment and terminal differentiation of hES cells. Neural commitment provides a paradigm for understanding the mechanisms by which ES cells choose between self renewal and lineage commitment. Furthermore, neuronal and glial differentiation of hES cells offer major new experimental avenues for cellular neurobiology and pathogenesis, with the potential for application in pharmaceutical and toxicological screening and cell replacement therapies. ESTOOLS draws together a team of high quality researchers with complementary expertise in mouse ES cell systems, human ES cell culture, epigenetics, neurodevelopment, and a range of genetic modification technologies. ESTOOLS will create a range of training opportunities and dissemination vehicles to transfer knowledge and experience wit