RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Automotive Mechatronic Baseline for  Electric Resilient Ultra Light Vehicle' under Seventh Framework.

assistant: **Concept**

Ultra Light Vehicles (ULV) intrinsically have a better efficiency due to their improved transport capability per vehicle mass. Additionally improved driving dynamics performance can more easily be achieved because of the reduced mass.However, the design of ULV sharing the same road with heavier cars represents a complex technical challenge for achieving acceptable safety levels. Furthermore, at present the additional purchase costs of a pure battery electric vehicle one as compared with a gasoline is more than 15000 Euros. Consumers buy a new vehicle because many and diverse reasons, including purchase price (one of the main concerns of the majority of buyers when approaching to purchase a new vehicle), depreciation rate, styling, performance and handling, brand preference and social image. However, car owners tend to underestimate the costs of running a vehicle. Although they are very well aware of fuel costs, road tax and insurance, they do not always account for servicing, repair and cost of depreciation. Therefore, if one is interested in comparing the cost of EV with other competing vehicle technologies the parameter of interest should be the Total Cost of Ownership (TCO).The project proposal AMBER-ULV aims to develop and integrate several innovative concepts, resulting from successfully completed R&D projects, giving a socially acceptable answer to safety concerns but not penalising the driving experience.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Portable Particulate Detection Device' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Asbestos fibres are a major cause of disability and death in the construction, decommissioning and related industries. The ‘Porpardet’ project will address this through developing two innovative complementary portable automatic detection systems, based on novel concentrating and analysis methods for asbestos particles and certain other harmful materials of widespread concern, eg mineral quartz/silica. One system will be a wearable device with an immediate alarm, the second will provide rapid on-site quantitative analysis - both will have the ability to record exposure over time with a novel filter cassette. This equipment will directly improve the health protection of the individual, and reduce the potential cost of their healthcare provision and possible costs of litigation. It will be of great value to the manufacturing, construction, waste disposal sectors, and emergency services. It will allow application of relatively inexpensive resources in a rapid manner, but with proper risk management. The automation and simplicity foreseen will allow an ease of use and therefore an uptake in use which will not only lead to wider control, but will also allow moderate production costs for the equipment - which uses many elements now emerging from other industries such as low cost lasers.   The project will deliver two new products with related consumable sales. The products will be designed, manufactured, distributed and serviced by the SME partners within the project. It is estimated that the new products could generate a new market in excess of 12 million Euro per annum for the SME partners. The SME partners will be responsible for the manufacture, supply of the optics, filter system, detector system, image capture software and final assembly of the full system. A number of p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Innovative Software for Advanced PET Imaging'.

assistant: **Objectives**

The need for detecting smaller lesions, earlier stage cancer, and test new radiopharmaceuticals ask for new PET imaging devices, especially in terms of improved spatial resolution and sensitivity. AX-PET is a novel PET concept, with an unprecedented design and unique features. Several layers of axially-oriented crystals are read out by WLS strips located underneath each crystal plane, providing a 3D parallax-free reconstruction of the gamma interaction point in the crystal matrix. The layered structure and the high spatial and energy resolution of AX-PET allows a high identification and reconstruction of inter crystal scattering events, resulting in a higher achievable sensitivity. However, the potential homogeneous spatial resolution and the higher sensitivity need to be supported by dedicated and advanced software. The aim of the presented project is the development of a complete system model, and of dedicated algorithms for image reconstruction and inter-crystal scatter identification, to support and to boost the development of the AX-PET demonstrator as well as to fully exploit its characteristics. Many innovative approaches are required and foreseen, all based on a strong multidisciplinary platform: High Energy Physics, Instrumentation, Applied Physics, and Computer Sciences. The outcomes of the project, in spite of being conceived for AX-PET, will be able to be applied to other high resolution systems. Therefore, the project will have a direct impact on the accuracy of medical diagnosis and in biomedical research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CLOUD Initial Training Network' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of the proposed Marie Curie Initial Training Network is to establish a multi-site network of early stage researchers (ESRs, here predominantly PhD students) at 9 partner institiutions across Europe to investigate various aspects of  the interactions of cosmic rays with aerosols and clouds, which bears on the possibility of a ""solar indirect"" contribution to climate change. Besides the individual research of the ESRs at their hosting institutions, the major focus of the network will be two sets of common experiments on ion-induced nucleation and ion-aerosol interaction carried out at CERN to which all ESRs contribute. These experiments are conducted at an aerosol chamber that is exposed to a CERN elementary particle beam where the effects of cosmic rays on aerosol and cloud formation can be efficiently simulated.  A comprehensive training programme is set up for the network participants. Additional to the experiments at CERN, the trainees are brought together by several network training events such as annual summer schools and workshops. Here, courses and lectures by world leading experts are taught spanning from ""aerosol chemistry and physics"" in general to specialized sessions on subjects such as ""ion-induced aerosol nucleation"" or ""influences of galactic cosmic rays on paleo-climate"". The summer schools and workshops are scheduled in addition to the national PhD programmes of their hosting institutions where a variety of courses is available to the ESRs . The summer schools will include training on complementary skills such as ""writing scientific publications"", ""preparing and presenting talks and seminars"", ""interaction with media"", ""commercializing scientific results"". A multitude of secondments are proposed in which individual ESRs visit othe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Unfoldings and Bifurcations of Polynomial Differential Systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

We investigate  the versal unfolding and bifurcations of planar polynomial differential systems having some topological structure. Specially,  we classify the systems of high degree which have centers  or degenerate equilibria. Then we study the  degeneracy of the system and prove the existence of versal unfoldings. All possible bifurcations of  unfolding  systems will be discussed and  topological phase portraits of the systems are presented.  Finally, we give a rigourous mathematical explanation for our results in some bio-mathematical models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modalities to delay, suppress and attenuate HIV-1 resistance for chemotherapeutics directed against reverse transcriptase' in the context of a Fourth Framework call.

assistant: **Objectives**

The objectives are (i) to obtain profound insights into the molecular resistance mechanisms of HIV against reverse transcriptase inhibitors; (ii) to define the HIV-1-specific NNRTI pocket on RT by crystallography and computer-assisted drug modelling techniques; (iii) to characterize a putative HIV-2-specific lipophylic binding pocket on HIV-2 RT; (iv) to formulate novel concepts and modalities to suppress, delay or control resistance development of HIV-1 against NNRTIs; (v) to investigate new tools to select for attenuated mutant virus strains.To achieve our goals, a multidisciplinary approach will be followed, including novel drug design and synthesis, modelling of drugs in the HIV-1 RT pocket, X-ray crystallography, virology, molecular biology, cell biology and enzymology. Resistance development of HIV-1 will be performed under a variety of experimental conditions, and the emerging mutant viruses will be geno- and phenotypically characterized, starting from a wild-type, NNRTI- and NRTI-resistance HIV-1 RT background. A search will also be performed for a putative NNRTI-specific binding pocket on HIV-2 RT that may be analogous to the NNRTI-specific HIV-1 RT pocket by the use of NNRTIs that also show activity against HIV-2.A comparative research will be performed on resistance development of HIV-1 against NNRTIs and NRTIs in lymphocytes and monocyte/macrophages. In this respect the effect of transient changes of cytosolic purine and pyrimidine (deoxy)nucleotide pool ratios during HIV-1 replication on the drug resistance development will be investigated in the presence of NRTIs and NNRTIs. Antimetabolites such as deoxycoformycine, methotrexate, hydroxyurea, hadacidine, mycophenolic acid and others will be included in this study. Co-crystallisation and modelling studies o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Phenotypic differentiation of mesenchymal progenitor cells within differential inflammatory environments'.

assistant: **Objectives**

Quality of life is very important in the context of European policy objectives. The anticipation of life expectancy and improved quality of life amongst younger Europeans, combined with an ageing population and associated increasing healthcare cost burden on society, means that new, cost-effective and efficacious medical treatments are required. In this context, Tissue Engineering (TE) has the potential to save lives, relieve suffering and meet the improved quality of life expectations.TE is a rapidly emerging collection of technologies aimed at the regeneration of tissues and organs for the treatment of disease and injury. Advances in basic biology as well as in material science provide us with great progress in the biomedical field. TE strategies together with the advances in mesenchymal stem cells knowledge represent a very promising combination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MAGNETOELECTRIC CHEMONANOROBOTICS FOR CHEMICAL AND BIOMEDICAL APPLICATIONS' to be submitted under Seventh Framework.

assistant: **Abstract**

The ability to generate electric fields at small scales is becoming increasingly important in many fields of research including plasmonics-based sensing, micro- and nanofabrication, microfluidics and spintronics.  The localized generation of electrical fields at extremely small scales has the potential to revolutionize conventional methods of electrically stimulating cells.  The objective of this proposal is the development of miniaturized untethered devices capable of delivering electric currents to cells for the stimulation of their vital functions. To this end, we propose the construction of micro- and nanoscale magnetoelectric structures that can be triggered using external magnetic fields.  These small devices will consist of composite hybrid structures containing piezoelectric and magnetostrictive layers. By applying an oscillating magnetic field in the presence of a DC bias field, the magnetostrictive element will deform, thereby generating stress in a piezoelectric shell, which in turn will become electrically polarized. Small devices capable of wirelessly generating electric fields offer an innovative way of studying the electrical and electrochemical stimulation of cells.  For example, by concentrating electric fields at specific locations in a cell, the behavior of protein membrane components such as cell adhesion molecules or transport proteins can be altered to modulate the stiction of proliferating cells or ion channel gating kinetics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'The EU Working Group on (Q)SARs'.

assistant: **Innovation**

Specific Objectives:To draft a JRC position document on the validation of QSARs, including the definition of acceptability criteria for QSARs and establishment of a formal validation procedure To prepare dossiers containing proposed QSAR models for use in the regulatory assessment of chemicals To perform/coordinate the independent assessment (validation) of proposed QSAR models To assess the scientific validity of QSAR models, based on the independent peer-review of the reports referred to in point 3. Anticipated milestones and schedule 1st quarter, 2003: Organisation of a meeting to reach agreement on the acceptability criteria for the development and validation of QSARs, taking into account ECVAM's validation criteria and the conclusions of the CEFIC workshop on QSARs.The meeting will involve the following participants: a) IHCP staff involved in the Action; b) the editors of 3-5 major journals that report QSAR studies; and c) representatives from EU regulatory agencies. Initiation of discussions regarding development of publicly-available database for deliverables of this Action. One possibility would be to upload the information onto a newly-developed part of the ECB website. 1st and 2nd quarters, 2003: Establishment of a QSAR development network" of experts from industry and academia in the EU and Candidate Countries.Solicitation of dossiers containing the case for the validation of QSAR models. The proposers of QSAR models will not be paid for their work, since it is assumed that they will being developing the models anyway. Establishment of a "QSAR assessment network" of experts from regulatory agencies (e.g. Danish EPA, UK HSE) and recognised validation authorities in the EU. For each dossier, or set of related dossiers, IHCP staff involved in the Action will ide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Higher Order Parton Showers and Resummation to meet the High Luminosity LHC's accuracy goal' (HOPSRES) under Horizon Europe.

assistant: **Objectives**

With the upcoming high-luminosity phase of the Large Hadron Collider (LHC), the high energy physics community is gearing up to explore the fundamental building blocks of our universe with unprecedented precision. Consequently, the demand for precise and widely available theoretical predictions is at its highest level. Resummation of logarithmically enhanced terms plays a crucial role in achieving accurate phenomenological predictions, in addition to higher-order fixed-order predictions.During my fellowship, I will to work on the design, implementation, and application of tools dedicated to Next-to-Next-to-Leading Logarithmic (NNLL) resummation, including novel applications, as well as the first complete dipole parton shower with validated NNLL accuracy. Both represent critical tasks to meet the accuracy needs of the next phase of the LHC and of future collider experiments.As a first step, I intend to extend the established CAESAR formalism for NLL resummation to NNLL, inside a comprehensive framework within the Sherpa event generator, one of the major simulation tools used by the LHC experiments. The Sherpa-CAESAR framework will then be extended to accommodate hadron collider environments like the LHC. The integration of this baseline for NNLL resummation serves as a foundation for the following efforts. Subsequently, I plan to enhance the recently introduced Alaric parton shower with inclusion of established Next-To-Next-To-Leading Order (NLO) splitting functions. Ultimately, I will utilise the tools and methods developed in the initial phase to validate the NNLL accuracy of the enhanced Alaric parton shower.By the projects conclusion, not only will a significant enhancement in NNLL resummation have been realised, but novel novel strategies for NLO subtraction and part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Factors contributing to variation and robustness in transcription'.

assistant: **Concept**

Development of multi-cellular organisms is an ideal model to study the sources contributing to phenotypic variation, such as disease susceptibility, agriculturally or evolutionarily important features. The corollary question, regarding factors that contribute to the robustness of development and phenotypic stability, is however under-appreciated.The project aims to identify factors that influence the variation and stability of transcription of genes regulating the early development in Drosophila (an unparalleled model species). To this end, several steps will and have been taken. Firstly, population samples show that there is considerable variation in regulatory sequences within D. melanogaster, with several mutations affecting DNA known to be important for expression. The plan is to extend this survey to more genes and survey additional species. Secondly, the focus is on the intrinsic noise in expression, and testing explicitly the novel hypothesis that somatic mutations in the DNA binding domains of Transcription factor proteins contribute. The third component relates to the second, and centres on testing the utility of fruitflies as a model species to study somatic mutations at the DNA level.A combination of cutting edge population and experimental genetics will be applied to study the stability of development in this unique system. This can identify the factors affecting stability and variation in phenotypes, and by testing the effects of somatic mutations, the study is designed to improve our understanding of the material basis of cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European cooperation network to collect & disperse ethical, safety & regulatory data in order to facilitate clinical implementation of gene transfer technology (gene therapy)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

In the rapidly moving area of gene therapy, fast adaptation to evolving knowledge is essential in order to better define ethical & safety provisions. The Euregenethy 2 will continue to focus on the ethical, safety and regulatory issues related to clinical implementation of gene transfer technology in order to facilitate and help harmonise it. Our current objectives are threefold:(I) Fostering interaction between regulators, scientists and industry;(ii) Offering a potential for a referral organisation following-up on evolving technologies;(iii) increase public accountability. Means to achieve these goals are:(1) organisation of focused meetings and maintaining sessions at ESGT;(2) publication of an annual newsletter;(3) Interactive web-page;(4) Initiate safety & technology data-bases; GT-products & cell biology (including stem cells);(5) Clinical trials data-base including a survey of successful trials.