RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity'.

assistant: **Objectives**

Clear evidence supports associations between endocrine disrupting chemical (EDC) exposure and impaired neurodevelopment. Yet, current hazard assessment of EDCs does not address developmental neurotoxicity. This is due to lack of scientific knowledge on how endocrine disruption is linked to developmental neurotoxicity (DNT). Thus there is an urgent need for novel testing and screening tools to address ED-induced DNT, based on new scientific knowledge. This calls for rapid advances in basic research as well as in the development of screening and testing tools close to the end-users. ENDpoiNTs will address this need by i) integrating advanced expertise in the EDC and DNT fields, two so far rather independent toxicology communities, and ii) continuous interaction with European and international key stakeholders. By combining state-of-the-art in silico and in vitro tools, innovative experimental designs and technologies, and advanced biostatistics on human epidemiological and biomonitoring data, ENDpoiNTs will 1) Generate the necessary scientific insights on the correlative and causal links between endocrine disruption and DNT; 2) Develop predictive in silico tools for chemical screening using machine learning and combination of evidence; 3) Develop and validate in vitro tools for chemical screening and testing that address sex- and species differences; 4) Develop novel molecular endpoints for existing animal-based test guidelines by integrating in vitro, in vivo, and human omics data with behavioural outcomes; 5) Ensure human relevance by linking experimental and epidemiological evidence; 6) Develop an integrated testing approach based on the developed in silico, in vitro, and in vivo assays and molecular markers; 7) Ensure regulatory relevance by developing strategies for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Validation of a personalised medicine tool for Multiple Myeloma that predicts treatment effectiveness in patients' (MMpredict).

assistant: **Innovation**

The consortium aims to commercialise the MMpredictor as a personalised medicine tool that predicts the most effective treatment strategy for individual Multiple Myeloma (MM) patients. MM is the second most common form of blood cancer contributing to 15% of all blood cancers and ~1,5% and 2% of all cancer deaths annually in the EU and US, respectively. Patients show a large variability in treatment response and side effects due to tumour heterogeneity and the patient’s intrinsic characteristics. Therefore, not every treatment will be suitable for each patient, and treatment strategies are often based on trial-and-error. The availability of multiple (>20) treatment options complicates treatment decision-making even more. With the current development of many more promising treatments, there is an urgent unmet clinical need for a diagnostic assay that supports personalised cancer treatment in order to improve patient health outcomes, prevent side effects and reduce healthcare costs.SkylineDx has previously developed the MMprofiler, a microarray-based diagnostic test that can subtype MM patients and reliably predict MM patient survival (prognosis). In this project, the test’s clinical value will be expanded to include the prediction of treatment effectiveness in individual patients based on Gene Expression Profiling. An addendum for new intended use will be filed to the current in vitro diagnostic (IVD) registration, while renaming the test to MMpredictor. The project will also focus on positioning the test as a cost-effective IVD test for personalised medicine, that will increase health outcome and quality of life of patients and reduce healthcare costs.The consortium consists of a life science SME specialised in molecular diagnostics, clinical centres with world renowned K
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Circular RNA Therapeutics for Duchenne Muscular Dystrophy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

RNA therapeutics is an emerging field explored in various types of diseases such as genetic disorders, cancer, inflammation and viral infections. Currently, most of the research focuses on the delivery of mRNA molecules that will transiently express a desired protein that can replace a defective protein or manipulate gene expression in the cells. My lab was the first to show systemic, cell-specific delivery of mRNA molecules in animals. Our approach and our novel amino lipids were translated to several clinical trials in the field of infectious and monogenic diseases. In protein replacement therapy, the main hurdle of using mRNA is the relative short half life of the mRNA. To address this, I suggest an approach for long-term expression: Circular RNA (circRNA), a covalently closed loop single stranded RNA that has a significant prolonged stability compared to linear mRNA. Thus, presents an immense advantage in protein replacement therapy. Duchenne muscular dystrophy (DMD) is caused by X-linked recessive mutation in dystrophin gene, leading to lack of functional dystrophin protein. This disease affects 1:5,000 males, causes a progressive loss of muscle tissues, ultimately leading to disability and premature death. Because DMD pathology is caused by the lack of functional dystrophin, restoring the function of dystrophin is a potential therapeutic strategy. As Lipid nanoparticles (LNPs) are the most clinically advanced candidate for RNA delivery, able to entrap large RNA payloads, herein I propose an innovative multidisciplinary approach for the specific delivery of circRNA-LNPs to muscle cells that will express the dystrophin protein and replace the defective one in a DMD mouse model. The long-term expression of the circRNA will offer new hope for the treatment of monogene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Systems Networks Norms' (SYSNORM).

assistant: **Concept**

Genomic sciences are driving progress in biology at an unprecedented pace, most recently through third-generation sequencing and synthetic biology. These achievements challenge commonly accepted biological concepts and assumptions in the humanities. In this Fellowship I will investigate the impact of genomic sciences on theory development in the social and human sciences, with focus on philosophy and ethics, and develop innovative normative models that align with this new knowledge. Harvard University will provide a unique setting for this investigation through its juxtaposition of front line genomics and medical research with rich humanities resources.My hypothesis is that systems approaches in biology are replacing traditional ontologies of health and disease - based on compendia of symptoms and test reference ranges - with emergent states and activity levels of nonlinear genetic networks. These concepts will induce substantial changes in objectives of basic research, translation of this research into practice, and, ultimately, the delivery and prioritization of health services. This shift must be assimilated into the philosophy and ethics that appraise these activities.Research and training at the Church lab at Harvard Medical School, a Center of Excellence in Genomic Science, will propel my academic career and bring innovative knowledge to Europe. The plan will be to work hands-on with genomic scientists to identify and develop specific examples of pathway characterizations that are in the process of replacing current health and disease categories, extrapolate how these foundational changes will translate into basic research and health care practices, and use the network examples to develop a blueprint for a systems biology-relevant normative model. Specific trainin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Smart Electric Vehicle Value Chains' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objectives of sustainable road mobility, i.e. energy efficiency, climate protection, and zero emissions, imply a paradigm shift in the concept of the automobile regarding its architecture, design, materials, and propulsion technology. The fully electric vehicle (FEV) is widely considered the most suitable option for the 'green' car of the future, even though it is still facing a multitude of major challenges in terms of product maturityIn order to maintain its role as the world's largest producer of cars, Europe has to anticipate the challenges of a move towards the FEV and adapt its automotive value chain to them in due time. The proposed Coordination Action Smart EV-VC will develop, recommend and initiate a multitude of tangible measures for this purpose, including the definition of common goals in terms of unique selling points of the FEV made in Europe, the compilation of a European roadmap, the promotion of novel links in the European FEV value chain by e.g. developing harmonized curricula for education and training, initiating standards, and drafting concepts for shared facilities as well as giving advice for the inclusion of small and medium sized enterprises (SME).Based on initial FEV related technology roadmap activities by members of the European Technology Platforms EPoSS, ERTRAC, and SmartGrids in the Public-Private Partnership European Green Cars Initiative, and sustaining the work carried out previously within projects funded under the umbrella of this initiative, the Smart EV-VC project will compile a dedicated implementation agenda in preparation of Horizon 2020, also aiming at coherences and complementarities of EU and members states programmes. It will cover strategic research, development and innovation for the FEV made in Europe" with a particula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'U-space Air and Ground Risk modEls Enhancement' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

U-AGREE aims to develop an integrated risk model linking the operations of unmanned aircraft (UAS) with some negative effects they may have with regard safety, security, privacy and environment. This risk model is intended to support the airspace risk assessments required by U-space European regulation as well as an amendment to SORA methodology so that risk can be quantitatively estimated, enabling digital implementations leading to swifter operational approval processes. Moreover, the U-AGREE risk model will account for U-space services to mitigate the risk, thus reducing the burden of meeting the SORA operational safety objectives and unleashing operations and business models which are currently economically unviable. To achieve these goals, U-AGREE will start by identifying realistic scenarios where UAS operations will take place and will assess them to identify all the hazards that these operations can pose to safety, security, privacy and environment. Next, the project will agree metrics and thresholds to measure the risk due to these hazards with relevant stakeholders (especially civil aviation authorities and common information services providers). Afterwards, the team will develop mathematical models linking the hazards with their effects (either on the ground or in the air) and will define mitigation barriers using U-space services, as well as algorithms to quantify their effectiveness in terms of risk ratios. These models will be integrated into state-of-the-art U-space simulators to evaluate the applicability and relevance of the proposed integrated risk model in the representative scenarios previously identified by the project. To synchronise the project outcomes with the U-space deployment, a first version of the risk model addressing short term needs will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SEVENPRO - Semantic Virtual Engineering Environment for Product Design' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The objective of SEVENPRO is to develop technologies and tools supporting deep mining of product engineering knowledge from multimedia repositories and semantically enhanced 3D interaction with that knowledge in integrated engineering environments. CAD designs, documental repositories and ERP/corporate DataBases will be the main data and knowledge sources supported. SEVENPRO will bring together the so far distinct worlds of 3D design data and other representation formats of engineering knowledge.The project will thus improve the process of product engineering and development in manufacturing and engineering companies, by means of semantically (ontology-based) supported acquisition, formalisation and management of product knowledge. Process improvements will be measured by criteria such as the time required for a product innovation, the level of company reuse of existing knowledge, and the reduction of engineering costs.Specially targeted to engineering companies and manufacturers with own RTD and complex products, the project aims to develop technology and software components to be integrated in product engineering environments. SEVENPRO will cope with the most important problems this kind of companies have to face, such as: disperse and heterogeneous knowledge repositories (technical documentation, CAD designs, etc.); knowledge sharing among team members; increasing product complexity and customisation; long product cycles; and transfer of new product knowledge from RTD to other departments and to the market.Scientific and Technological objectives of the resulting SEVENPRO are oriented towards solving concrete industrial challenges for product engineering teams and focus mainly on the following: semi-automatic semantic annotation of Multimedia design resources (CAD, ER
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Beyond Restitution: Heritage, (Dis)Possession and the Politics of Knowledge', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

On the backdrop of ongoing debates to decolonialize museums, BEYONDREST asks if the return of looted art can be regarded as a closure of historical wounds. The project probes the focus on restitution that inadvertently casts dispossessed art in terms of contested property. Instead, BEYONDREST explores what kind of loss dispossessed art engenders, and how this loss has shaped the knowledge production on heritage. It focuses on the interlocution between Western Europe, the Near and Middle East, and North Africa, mapping relationships between people and “things” that have largely been left out of current debates. The project starts in the mid-19th century, which witnessed the rise of the museum in its modern form as well as violence unleashed by imperial and colonial projects and dispossession. Innumerable objects made their way into international collections, categorized mostly as “Islamic art,” or as the “universal heritage of humankind” that nonetheless symbolically and proprietarily belongs to the “West.” BEYONDREST tackles dispossession not as a loss to be mended but a means to transform knowledge through inquiries into absence. The interdisciplinary research group will employ a wide methodologically matrix, including ethnographic interviews, visual analysis of exhibitions, archival research, and textual analysis of the laws governing cultural assets to capture the proprietary stakes in the interplay of epistemic remembering and forgetting. BEYONDREST takes risks by centering on what is absent, rather than present, on what is lost, rather than found. It argues that the dispossession of art is not merely a problematic of colonialism or empire, that is of the past, but an ongoing process that is constitutive for the governance of heritage in its national and transnation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Optimising the impact and cost-effectiveness of child health intervention programmes of vaccines and micronutrients in low-income countries'.

assistant: **Concept**

International child health programmes in low-income countries are justified in term of their impact on child survival. However, the effect estimates are usually calculated from performance indicators and assumptions about efficacy based on small-scale target-specific studies. There is little follow-up of how the programmes are implemented in real life.This approach is clearly not sufficient. Recent studies have consistently shown that vaccines and micronutrients have non-specific effects, i.e. effects which are not explained by prevention of the targeted infections or deficiencies. These effects are often sex-differential. Furthermore, interventions may interact. Hence, the overall impact of child health programs can not be extrapolated from small-scale target-specific studies. There is a need to assess the real life impact and cost-effectiveness of child health intervention programmes in the context where they are being used.We propose to use health and demographic surveillance system (HDSS) sites in Africa to register information routinely on all interventions in childhood, such as all vaccinations, micronutrient supplementation, and de-worming, given at health centres or in campaigns. Using this information we will measure the overall health impact of the child health programs.The HDSS platform can also be used for testing modifications of the current health programmes. We will test a recent finding from a randomised trial in Guinea-Bissau: providing early measles vaccine at 4.5 and 9 months of age compared with the recommended measles vaccine at age 9 months reduced overall mortality from 4.5 to 36 months of age by astonishing 49%.The HDSS sites already collect data on mortality, and mortality would be the main outcome, but we also aim to identify other relevant com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DEVELOPMENT OF ADVANCED ACTUATION CONCEPTS TO PROVIDE A STEP CHANGE IN TECHNOLOGY USED IN FUTURE AERO-ENGINE CONTROL SYSTEMS (ADVACT)' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Major strides have been made in monitoring and control for gas turbines engines. Very little has changed in what is physically controlled or the actuator mechanisms themselves. Variables on civil aircraft remain largely restricted to fuel input, guide vanes and bleed valves. All other components redesigned as a compromise between efficiency at different operating conditions and the need to maintains table operation over the entire operating range. Recent developments in available actuation mechanisms have been identified as providing many opportunities for new control functions that could provide a major step change in the capabilities of the machines. Internal company reviews and internationally reported programmes have identified many control functions and mechanisms that could be used. Just one application of these technologies has already been identified as saving 0.3M Euro per aircraft year on transatlantic flights and a fleet CO2reduction of 8M Tonnes per year by 2020There is a continual push to improve system performance for a number of commercial and legislative objectives. These can be largely grouped as cost, competitive position and environmental impact. Advanced Actuation will help to address these issues with improved engine performance. To achieve this there is a need for imaginative research into the basic technologies that have already been identified and extensive studies to consider the manufacturing, operational and environmental issues.The programme has three main elements;Quantify the performance and operational benefits of extended actuation capabilities.Research into selected technologies for the gas turbine environment (MEMS, SMA, Advanced Electromagnetics, Boundary Layer Manipulation and Active Vibration Control).Evaluate the selected technologi