RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanisms at the interface of DNA damage repair and transcription' (STOP-FIX-GO) targeting Horizon Europe.

assistant: **Abstract**

Bulky DNA lesions are a major obstacle during gene transcription by RNA polymerase II enzymes (RNAPII). The stalling of RNAPII at DNA lesions triggers a genome-wide transcriptional arrest. Transcription-coupled repair (TCR) is a specialized DNA repair pathway that selectively removes DNA lesions from actively transcribed genes to restore transcription. Stalled RNAPII at DNA lesions forms a roadblock for advancing DNA replication forks resulting in toxic collisions. The mechanisms that enable the repair of transcription-blocking DNA lesions, the restoration of transcription after repair and the resolution of transcription-replication conflicts are poorly understood. To address these knowledge gaps, I propose to establish a series of innovative approaches aimed at identifying the mechanisms involved in the cellular responses to transcription-blocking DNA damage. We will focus on the functional characterization of known and several promising new TCR factors that we recently identified in combined genome-wide CRISPR and targeted proteomics screens. I propose to dissect the role of known and new TCR proteins by (1) applying a genome-wide approach for directly measuring TCR activity in combination with proximity-labelling proteomics and genetic-interaction mapping to define how TCR complexes assemble and operate, (2) identifying the mechanisms in transcription restoration by combining advanced genomics methods to map nascent transcripts, monitor RNAPII occupancy, and correlate these with specific chromatin modifications in a genome-wide manner, and (3) dissecting the mechanisms involved in resolving transcription-replication conflicts by combining functional DNA replication assays with genome-wide approaches to map transcription, R-loops and DNA replication directionality. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development and validation of an integrated numerical tool for scaling control and squeeze treatment optimization (ARISSTON)' to be submitted under Fifth Framework.

assistant: **Abstract**

Objectives and problems to be solved :An old but persistent problem facing the oil industry is the formation of mineral scales from produced water/brines in oil/gas wells and pipelines. Lost production, formation damage and operational expenses caused by scale deposits cost hundreds of million US$ every year. The main objective of this project is the development and validation of an integrated numerical tool that can assist in the design and optimisation of a squeeze treatment for the prevention of scaling. The tool should predict the timing of scale deposition, the consequent formation damage distribution and the placement and flow of inhibitors in the near well formation. The validation of the tool involves both laboratory and field scales. Its application should reduce greatly the lost production and operational costs since it provides the chance for optimal design of the squeeze treatment (selection of inhibitor, inhibitor concentration, size of the pill, etc.) and for in-time placement of inhibitors at the zones where scaling is expected. Description of the work :The integrated numerical tool is to be built on a modular basis, with each module having an autonomous function, to facilitate testing, validation and upgrade. The tool consists of the following:1. The main module, which is a single well, three-phase model simulating the fluid and heat flow in the well and the near-well formation.2. The geochemical module for the simulation of chemical reactions.3. The deposition/dissolution model for the computation of permeability and porosity alterations. The inhibitor flow model. Most of these numerical algorithms and their respective codes already exist, but they have to be tailored and integrated to the needs of the project. For the development and validation of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AuTonomous intraLuminAl Surgery' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In modern surgery body lumens increasingly serve as access route to deeply located anatomic regions. Navigation through narrow and mostly fragile and deformable lumens requires considerable skill, dexterity and consequently imposes a large mental load. Visualization is notoriously poor. Due to phenomena such as slack, backlash and compliance the controllability of the instruments is bad. Surgeons undergo steep learning curves and even experienced surgeons often lack confidence about their gestures. Surgical risks including internal bleeding, tissue damage, puncture or rupture are imminent. ATLAS will produce a generation of European researchers that will develop robotic skills and techniques to automate complex surgical intraluminal therapies. Due to physiological phenomena or the surgical action the anatomy changes considerably, reducing the value of pre-operative data and imaging. Compliant instruments must be employed to navigate through lumens. As they proceed they deform and undergo complex and distributed contacts with the fragile environment. Step changes in intra-operative and distributed sensing, real-time modeling and 3D reconstruction, decision-making, intra-operative planning and autonomous control will be made to deal with the extreme variability that is encountered. Whereas assistive technology for steering flexible endoscopes, ureteroscopes, colonoscopes, guidewires and vascular catheters has been notoriously disparate and incoherent, ATLAS will develop and train researchers in identifying and exploiting the commonalities amongst these cases. This generalization will lead to a rigorous unified framework and guidelines to deploy assistive techniques tailored to each specific therapy. The ATLAS consortium consists of Europe’s leading institutes in the field
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Small-scale processes in complex terrain' (ROTOR) targeting Seventh Framework.

assistant: **Abstract**

This is a proposal for a reintegration activity at the Department of Meteorology and Geophysics at the University of Vienna. Proposed is an atmospheric study of small-scale processes in complex terrain that cover a range of atmospheric conditions and terrain configurations. The small-scale orographic phenomena to be examined include the following: 1) Gap flow and flow channelling in the Hinlopenstretet between the Spitzbergen and Nordaustlandet islands in the Svalbard Archipelago, 2) Atmospheric rotors in the lee of the Sierra Nevada in California and the Snowy Range in Wyoming, 3) Mountain waves and rotors in the airflow past Villarrica volcano in the Andes. These phenomena and the dynamical processes governing their generation and evolution will be examined using high-resolution airborne observations, including in situ and remote sensing data, that has been collected during several recent observational field campaigns (e.g., THORPEX-IPY, T-REX). The observational data analysis will be done in conjunction with high-resolution real-data and idealized numerical simulations using a mesoscale atmospheric numerical model (WRF) for dynamical process studies. The objective of this research is to advance our understanding of small-scale severe phenomena in complex terrain. The results of this research are expected to lead to improved accuracy of numerical weather prediction in mountainous regions. The reintegration strategy rests on building a center of excellence in mesoscale dynamics and modeling research within the Theoretical Meteorology group at the Department of Meteorology and Geophysics at the University of Vienna.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bioinspired composite architectures for responsive 4 dimensional photonics' (BIO4D) under Horizon Europe.

assistant: **Objectives**

BIO4D aims to achieve a fundamental understanding and develop a true biomimetic model of natural responsive photonic systems. From air (Paradise bird) to land (Panther chameleon), and soil (Hoplia Argentea beetle) to water (Neon Tetra fish), nature has enabled organisms to morph their colour, visibility, and reflectivity, to camouflage, signal, mimic, distract, and regulate biological processes. Due to the complexities of these systems, true synthetic analogues have not been achievable to date. BIO4D will develop novel responsive 3D photonic structures by combining self-ordering photonic nanomaterials with state-of-the-art 3D fabrication at the nano and micro-scale. This will enable dynamic photonic behaviour including controllable refractive index, adaptable reflectivity and transmission, angle independency, and stimuli response. This highly ambitious goal will be achieved by:-Developing self-ordered photonic nanomaterials in stimuli responsive hydrogel networks.-Understanding the effect of combining photonic substructures and superstructures (fabricated via 2-photon polymerisation) using Finite-difference time-domain analysis.-Fabricating biomimetic 3D photonic structures from composite hydrogels, using 2-photon polymerisation.-Demonstrating 4D photonic structures that show on-demand dynamic optical response.This will enable truly biomimetic models through self-ordering nanomaterials (modelling keratin and chitin), stimuli-responsive materials (modelling motor proteins and actin filaments) and 3D direct laser writing (yielding ordered and disordered superstructures). These stimuli-responsive photonic structures will offer a direct pathway to applications in active display technologies, biometric recognition, polarisation encryption, and extremely low-cost sensing in l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Computing On Demand for Electromagnetic Software and applications' under Sixth Framework.

assistant: **Concept**

Electromagnetic software plays a key role in the design and manufacturing of innovative electronic sub-systems: wireless components, micro sensors, smart antennas, high-frequency active and passive devices, MEMS, etc. These new emerging devices have a major impact on a large number of strategic applications, such as mobile communication, broadband networks, security systems, earth remote sensing, transport monitoring, de-mining, tele-medicine etc. by determining their technical feasibility. During the last years, the SMEs involved in this proposal developed and maintained state-of-the-art electromagnetic software offering services to Industries worldwide and achieved a solid international market success thanks to the result accuracy and the reliability of their software tools. New products coming from USA and Far-East are now reducing the competitive edge and the proposer SMEs believe that, in the next future, the marketing success of their products will be strongly dependent from the computational speed of their software. Higher and higher performances will be, in fact, required to face increasing sub-system complexity and reduce design time. In the past, parallel mainframes were used to improve performance, but the high costs due to new hardware and software modifications limited its usage to very narrow applications. Today, GRID computational technology offers a robust and seamless environment to achieve high speed performance and, in this frame, the involved RTD Providers are committed to develop a GRID solution, able to exploit at best the latest Information Technology developments applied to the electromagnetic design. The outcome of this research project will enable the proposer SMEs to commercialise a software add-on product able to boost the performance of thei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Microbicide Optimization Through Innovative Formulation for Vaginal and Rectal Delivery' (MOTIF) targeting Seventh Framework.

assistant: **Abstract**

The 40% protection against HIV-1 infection with vaginally-applied tenofovir gel demonstrated in the CAPRISA004 trial, has emphasized development of anti-retroviral (ARV)-based microbicides. Combining ARVs in a single product may provide increased protection. Development of a generally applicable formulation platform for combining ARVs (even if chemically incompatible) and understanding of the processes (drug uptake, efflux and metabolism) that determine tissue levels of microbicide are two important gaps in knowledge necessary for microbicide development. We propose to identify drug uptake and efflux transporters in cervicovaginal tissue  and to use this information together with data on drug transporters from colorectal tissue to develop improved in vitro cell-based systems for biopharmaceutical screening. We also propose to develop a standardized drug encapsulation and formulation system that will allow insertion of any drug combinations. Informed by data on drug uptake, efflux and metabolism, these formulations will be further modified either by beneficial drug-drug interactions or by including selective inhibitors or inducers of drug  transporters to optimize drug concentrations at target tissue sites. Comparative studies of drug transporters will also be performed in two important animal models, namely non-human primates (virus challenge ) and rabbit (regulatory toxicology). Optimised drug formulations will be tested in vitro and will undergo pharmacokinetic and pharmacodynamics studies in the animal models. Project outcomes will include a detailed description of drug transport in colorectal and cervicovaginal tissue to provide a rational basis for microbicide formulation, platform technology for formulating microbicide combinations optimized for vaginal or rectal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Local buckling of structures in case of fire' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content . The objectives of this research are:- To develop new tools to determine the stability of steel, concrete and composite structures in case of fire. To get these tools, it will be necessary to develop a new shell element in the SAFIR code (it has been developed at the University of Liege). - To increase the safety of buildings in case of fire, through calculations that will simulate the effect of local buckling in case of ISO or natural fire and to reduce the cost of construction. - To get better knowledge of the behaviour of steel, concrete and composite structures. From a scientific point of view, the most interesting is the local buckling of steel structures an the interface between steel and concrete in the case of composite structures - To carry out calculations using the results from real fire tests such as in Cardington, to validate the new shell element. - To carry out theoretical calculations to check different points of Eurocode 3 part 1.2. such as the classification of steel profile in case of fire. The same study was carried out during the BCCF (Buckling Curves in Case of Fire) research. This research was sponsored by the CECA. It will result in a better adequation between theoretical calculations with Eurocode 3 part 1.2. and the real stability of the structure. Training content (objective, benefit and expected impact) The main objectives are to get better knowledge of the local buckling of steel beams and of the behaviour of the interface between steel and concrete in the case of composite structures, when these structures are subjected to fire. By understanding these phenomena, it will be possible to increase the safety of buildings. From an economical point of view, it should reduce construction costs by decreasing the num
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Combined database on microbial responses to the food environment'.

assistant: **Objectives**

This proposal is about the European extension of a database on microbial responses to food environments ( Combos), currently run buy a UK and a US research institute. An Internet-based, international database is proposed, for a repository for food microbiology data serving quantitative microbial risk assessment purposes. The database would pool publicly available data that fits into the Food environment => Microbial response " scheme. The compatible database protocol proposed here would help to standardise microbial data collection thus allowing direct comparison of the emerging data with that available globally. The large amount of microbial data of the final product (e-Combos) will be accessible fast and in user-friendly format via the Internet and would provide a reference database for food scientists and different international risk assessors."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Social Vulnerability and its Intersections: The role of gender in a comparative perspective' in the context of a Horizon 2020 call.

assistant: **Objectives**

VINE seeks to disentangle the multidimensionality of the risk of social exclusion, focusing on vulnerable populations; specifically, those individuals who are in a fragile condition with regard to integration into the domains of well-being (family, labour market, welfare state). Using EU-SILC microdata, the project analyses the interactions between social vulnerability and different individual characteristics that might magnify it. Secondly, the project intends to study how, and in what ways, these individual characteristics combine to determine economic insecurity at household level. The main contribution of this project is proposing an analysis of how the institutional context as well as individual characteristics affects individual risk of living in vulnerable households, from a comparative and multidimensional perspective. By comparing six European countries, as representatives of different institutional environments, the VINE project aims to deliver a better understanding of the causes and mechanisms that determine both men and women’s exposure to social vulnerability. The innovation herein is the assumption that gender is the main analytical dimension in interactions, when theorised according to the intersectional perspective. With a multi-dimensional explorative analysis, and multinomial logistic regression, the analysis will lead to the development of a synthetic indicator of economic insecurity at the household level, permitting assessment of its interactions with specific individual vulnerability profiles. The final aim is to disentangle factors informing individual’s exposure to different degrees of social vulnerability, analysing their consequences and household’s economic insecurity, and possible influences from the institutional context. Thanks to this pro