RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Aquabuoy demonstration offshore wave energy plant'.

assistant: **Concept**

This STREP project will demonstrate operational performance of a grid-connected 2 MW wave energy power plant to be located 10km off the Portuguese coast in a 60m water depth near Figuera da Foz. The AquaBuOY is a wave energy conversion device that makes significant advances in performance from ocean tested predecessor technologies. It is now ready for a full scale demonstration. A grid connection licence has been received from EDP in Portugal.The municipality expressed full support for the project. The project will achieve the following performance objectives: - # of devices | nameplate capacity (MW) up to 10 devices | 2 MW - Offshore site (distance | depth) ~ 10 km | 60 m - Technical availability > 80% - Energy production (MWh/yr) ~ 5000 - Capital cost (_/kW) < 1500 - Cost of energy (_/kWh) < 20 - Capacity factor (%) > 25 - Conversion efficiency (%) > 40 The project promotes introduction of an innovative, cost competitive renewable energy system from ocean waves.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'STructural stABiLity risk assEssment'.

assistant: **Innovation**

Europe’s Cultural Heritage (CH) is at risk, endangered by environmental processes enhanced by climate changes and anthropogenic pressure. Specifically the slow (landslides, subsidence) and seismic (earthquake) movements of the ground have a strong impact on the structural stability of the CH. To have an idea of the dimension of the phenomena, the damage on the CH asset declared by the Italian Ministry of CH, caused by the recent earthquakes in Centre Italy, has been assessed in 2 Billion Eur. In this scenario, authorities in charge to CH preservation have a strong requirement for systematic, effective, usable and affordable tools and services to forecast and monitor the degradation process to enable preventive maintenance and to reduce the cost of the restoration.STABLE addresses the design and development of a Thematic Platform, combining structural stability models, damage assessment simulation tools, advanced remote sensing, in-situ monitoring technologies, geotechnics and cadastral data sets with WebGIS application for mapping and long term monitoring of CH. This will enable effective monitoring and management of the CH to prevent, or at least reduce, catastrophic damages.STABLE will coordinate the existing expertise and research efforts of the participant beneficiaries into a synergetic plan of collaborations and exchanges of personnel to offer a comprehensive transfer of knowledge and training environment for the researchers in the specific area. The development of Platform will constitute for scientist the way to share and improve CH safeguard methods, and to professionals to apply the most advanced technologies in the related fields.


**Keywords:** Structural Stability, Earthquake, Remote sensing, Cultural Heritage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CRISPR Point-of-Care Diagnostics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Monitoring of human health and the prevention/treatment of (infectious) diseases strongly depend on accurate and efficient detection, identification and tracking of pathogens or biomarkers. Key features of such a diagnostic tool that enable this are speed, accuracy and availability at the point-of-care. Current molecular diagnostic solutions do not meet these requirements due to the fact that they often need to be performed in a centralized fashion. However, the incredible advances in CRISPR-Cas technology in recent years provide an opportunity to change this. By taking advantage of the innate specificity of CRISPR-Cas we have previously developed a highly sensitive and accurate proof-of-concept diagnostic tool with promising results. The potential for implementation is unfortunately impaired by the fact that the workflow comprises of multiple steps that increases hands-on time, room for human error and the undesirable implications this has. To mitigate this, we propose a solution that entails developing a novel approach based on a thermostable RNA polymerase that allows for the condensation of the current workflow into a shorter 1-step protocol. Once such a protocol has been developed, an assay will be developed for one of the causative pathogens of chronic obstructive pulmonary disease (COPD). Technical feasibility of the assay will be demonstrated, in collaboration with an academic hospital, by characterizing the developed assay on relevant clinical samples. This will provide insight into the real-life performance when compared to the current gold standard (PCR) as well as ease-of-use in a relevant context. Furthermore, the feasibility of the value proposition and potential for commercialization will be thoroughly assessed. Not only will this ERC-PoC project shed lig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fast Tracker for Hadron Collider Experiments' (FTK).

assistant: **Concept**

This project aims to develop an extremely fast but compact processor, with supercomputer performances, for pattern recognition, data reduction, and information extraction in high quality image processing.The proposed hardware prototype features flexibility for potential applications in a wide range of fields, from triggering in high energy physics to simulating human brain functions in experimental psychology or to automating diagnosis by imaging in medical physics. In general, any artificial intelligence process based on massive pattern recognition could largely profit from our device, provided data are suitably prepared and formatted.The first goal consists in demonstrating the system can perform online track reconstruction of full events at the highest luminosities of the LHC and SLHC) at CERN, beyond the limits of any existent or planned device and despite the overwhelming confusion due to the very high track multiplicity and the exceedingly large event pile-up.With this goal we participate to the construction and the test for an high precision real-time tracker built for the ATLAS experiment: the Fast Track (FTK) processor. FTK can improve the capability of the ATLAS detector to select interesting events reach of heavy leptons or quarks within the enormous LHC background. It uses FPGA and ASIC chips to implement, real-time, complex track reconstruction algorithms. The track's trajectories are reconstructed in 3D, in few dozens of microseconds and the quality of the parameters is almost offline. FTK will increase the ATLAS discovery capability.In parallel we will pursue challenging R&D & new real time computing ideas for more complex applications. A new industry-academia cooperation will reinforce the FTK team making it suited for such applications. The knowledge tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Biobanking and Biomolecular Resources Research Infrastructure' (BBMRI) under Seventh Framework.

assistant: **Objectives**

The Preparatory Phase for a pan-European Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) will focus on technical, legal, governance, and financial issues to • prepare to construct BBMRI, building on existing biobanks, resources and technologies, specifically complemented with innovative components and properly embedded into European scientific, ethical, legal and societal frameworks, • provide the concept for a key resource to increase excellence and efficacy in biomedical sciences, drug development and public health, • expand and secure competitiveness of European research and industry in a global context, • develop a sustainable financial framework. Biomedical quality-assessed samples and data as well as biomolecular resources and molecular analysis tools are essential for academic and industry-driven research to treat and prevent human diseases. Although currently established national biobanks and biomolecular resources are a unique European strength, valuable collections typically suffer from fragmentation of the European biobanking-related research community. This hampers the collation of biological samples and data from different biobanks required to achieve sufficient statistical power. Moreover, it results in duplication of effort and jeopardises sustainability due to the lack of long-term funding. BBMRI will comprise: • biobanks of different formats (collections of blood, DNA, tissue, etc., together with medical, environmental, life-style and follow-up data), • biomolecular resources (antibody and affinity binder collections, ORF clone collections, siRNA libraries, proteins, cellular resources etc.), • enabling technologies and high-throughput analysis platforms and molecular tools to decipher gene, protein and metabolite functions and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Observational Prolonged Trial In Myotonic dystrophy type 1 to Improve QoL-Standards, a Target Identification Collaboration' (OPTIMISTIC), addressing dissemination and exploitation.

assistant: **Impact**

OPTIMISTIC is a proposal for a European collaborative project of doctors, scientists, relevant stakeholders (TREAT-NMD, patient organizations) and SMEs with the aim to improve clinical practice for patients suffering from a rare, inherited, and neglected disease, myotonic dystrophy type 1 (DM1). It is one of the most variable human diseases with complex, multi-systemic and progressively worsening clinical manifestations. Despite the huge impact of DM1 on the daily life of both patients and their family members, DM1 patients fail to receive the quality of healthcare that is available as they are not assertive users of the health care system.There is no cure for DM1. The aim of treatment is to relieve impairments, reduce limitations and support participation in everyday activities. Based on our DM1-specific model which shows that physical activity and experienced fatigue are main determinants of DM1 health status (Kalkman 2007), OPTIMISTIC investigates the effect of cognitive behavioural therapy (CBT) in combination with exercise training  to improve functional capacity and to stimulate an active lifestyle.OPTIMISTIC compares the outcome of a treatment regimen with regular management in a multi-centre, assessor-blinded, randomized controlled trial, designed to 1) result in evidence-based clinical guidelines on exercise and cognitive behavioural therapy in DM1, 2) capture clinically meaningful changes in existing and novel outcome measures, and 3) identify both individual and composite biomarkers as surrogate treatment outcome measures that are reflective of the disease state.There is an urgent need for an European clinical trial infrastructure for DM1. High prioritization of this is required to enhance the speed of clinical development of new putative DM1 therapeutics app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Human Rights – MUtually Raising excellence' (HURMUR), addressing dissemination and exploitation.

assistant: **Impact**

The project “HURMUR: Human rights – mutually raising excellence” will decisively expand the world-class research area of human rights in Europe. Tallinn University Law School will develop research excellence of human rights and become involved in global research and regional dissemination networks through specific activities of an outstanding consortium, where two other partners are premier global academic institutions in the field of human rights – the Danish Institute for Human Rights and Walther Schücking Institute of International Law (Kiel University, Germany). Their rennomee which is a guarantee that Tallinn University Law School will develop capacity to i) become a leader in the Baltic region of participating in state-of-the art research of human and fundamental rights, ii) initiate new research and development project of European magnitude exploring the changing nature of human rights in the contemporary society; iii) build bridges between Estonian/Baltic/Russian human rights research and activist communities.This goal is achievable via: i) organizational reform of Tallinn University’s International Research Centre of Fundamental Rights; ii) establishment and publication of a new regional peer-reviewed academic journal, the East European Yearbook on Human Rights; iii) strengthened research capacities of TLU on universality of human rights (including in particular freedom of speech, freedom of religion, and identity rights), and human rights narratives and discourses, and on new human rights (including rights related to well-being; rights related to the exercise of public authority; rights related to new technologies and rights related to identity and personality), as well as increased publication activity in this area; iv) increased dissemination and communicati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Philosophy of the Young Schiller (1773-1789). Education, Sources, and Issues' in the context of a Seventh Framework call.

assistant: **Objectives**

The proposed project is an interdisciplinary research on the philosophical development of Friedrich Schiller (1759–1805), one of the most prominent European intellectual figures between late Enlightenment and Idealism. The research considers the period from Schiller’s first attendance of philosophy classes in 1773 to his very first adoption of Kantian ideas in 1789, and will provide the first multi-faceted and comprehensive monograph on the young Schiller’s thought, as well as papers and presentations in Europe and the US. The main aim is to demolish the enduring myth of Schiller’s philosophical dilettantism and re-evaluate his philosophical stature independently of Kant.The method will be multi- and interdisciplinary, thus avoiding misinterpretations common to one-sided approaches, connecting the histories of philosophy, literature, ideas and universities. In particular, the research will focus on three aspects of the young Schiller’s commitment to philosophy: a) the curricula, dissertations, theses, speeches and lecture catalogues at the Stuttgart Karlsschule, where Schiller studied from 1773 until 1780; b) the impact of British moral/common sense theory, French Enlightenment and German philosophy on the making of Schiller’s thought; c) key  issues in Schiller’s early philosophy such as, for instance, God, knowledge, virtue, beauty, and love.An important shortfall in current scholarship that requires urgent attention and has been repeatedly highlighted in recent times, will thus be addressed.Lastly, the proposal fits closely with the Work Programme and its training objectives in terms of strengthened individual maturity, deepened interdisciplinary consciousness, new (transferable) skill acquisition, and wide dissemination. As a result, the appeal of the European Resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Diversification of the Eukaryotic Plankton  in the Sunlit Ocean' (PlankDiv) under Horizon Europe.

assistant: **Objectives**

Oceanic plankton constitute a diverse array of organisms crucial to Earth’s carbon cycle, climate regulation, and the functioning of the ecosystems. A key biological challenge lies in understanding the build-up of planktonic diversity in the global oceans. Two primary limitations are the scarcity of robust (phylo)genetic data for most plankton groups, and the lack of computational tools designed to explore diversification in the ocean, continually shaped by currents. Here, I propose to characterize the patterns and drivers of diversification across present-day eukaryote plankton groups by harnessing three main resources: i) recent global-scale surveys of oceanic samples, ii) emerging long-read metabarcoding technologies, and iii) my team’s expertise in developing innovative modeling tools.First, we will generate long-read metabarcoding data for over 800 plankton samples worldwide. We will characterize the diversity and distribution of major eukaryotic plankton groups above and below the species level. Second, we will develop an evolutionary model in the global open ocean, providing predictions on the mode and tempo of diversification. We will evaluate the role of current-mediated dispersal constraints and environmental selection in driving genetic differentiation and speciation.  Third, we will construct taxonomically rich phylogenetic trees for the major eukaryotic plankton groups and analyze variations in diversification rates through time and across oceans.  Fourth, we will reconstruct paleo-oceans throughout the Cenozoic era and elucidate how past environmental changes have influenced diversification dynamics. This proposal represents the first endeavor to conduct a comparative analysis of diversification across eukaryote plankton groups, from microevolutionary to m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Elucidating the mechanism of mechanotransduction through YAP and TAZ' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The mechanical properties of the cellular environment deeply influence cell fate and behavior. Cells respond to outer forces not only through the rapid remodeling of their cytoskeleton, but also by implementing gene expression changes. The Piccolo laboratory pioneered the notion that the transcriptional coactivators YAP and TAZ act independently of the Hippo pathway to activate gene expression in response to cytoskeletal tension. Crucially, YAP/TAZ are the main effectors of the cellular response to mechanical cues instructing proliferation, cell death or cell fate choice. Despite the importance of mechanosensing in development, tissue homeostasis and cancer, the mechanistic link between the actin network and YAP/ TAZ regulation has remained elusive.This project aims to close this gap in our knowledge by uncovering the molecular events that lead to the activation and nuclear translocation of YAP/TAZ in cells experiencing mechanical strain. Using live imaging, I plan to derive a model of the nuclear YAP shuttling dynamics. Optogenetic tools and targeted genetic approaches will be used to delineate which components of the actomyosin network are sufficient to regulate YAP/TAZ and to probe a potential link to nuclear mechanics. Mass spectrometry will provide a comprehensive view of YAP/TAZ interaction partners in cells subjected to different mechanical inputs and biochemical validation experiments will systematically delineate the molecular pathway of mechanotransduction from cytoskeletal tension to YAP/TAZ activation. Finally, loss- and gain-of-function experiments in a range of model systems will establish the functional importance and generality of these newly identified mechanotransduction pathway players. Uncovering the mechanotransduction pathway will not only greatly