RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular and biochemical pathogenesis of friedreich's ataxia: search for treatments.' in the context of a Fifth Framework call.

assistant: **Objectives**

The final goal of this proposal is to identify treatments and outcome measures for multicenter treatment trials for Friedreich's ataxia (FRDA), the most frequent cause of inherited ataxia and which is of exclusive European/Caucasian origin. We will develop mouse and cell culture models of FRDA, which will be used to identify mechanisms by which reduced expression of frataxin, the defective mitochondrial protein, or expression of mutated frataxin causes cell death. Possible treatments interfering with the proposed pathogenesis will be tested in the in vitro and in vivo models. Giving its slow progression and the phenotypic variability, FRDA may be a difficult disease to study for therapeutic intervention. Therefore, we will try to identify biochemical markers of oxidative stress and mitochondrial dysfunction, which in later therapeutic trials may be followed as primary outcome measures for the effectiveness of a treatment.D 1.2 and D 1.3 Biochemistry of DYFH1 yeast mutants and genes interacting with YFH1. This work has identified the metabolic pathway of yeast frataxin : the mitochondrial iron-sulfur (Fe-S) cluster biosynthesis machinery (Duby et al. 2002). It has identified the functional and physical partner of yeast frataxin: Isu1p, the protein that serves as a scaffold for 2Fe-2S cluster assembly, and it has provided biological support to the in vitro view that frataxin may be an iron donor to Isup (Ramazzotti et al. submitted). D 2.2 and D 2.3 Conditional and inducible frataxin knock-out mice. Four transgenic mouse lines that recapitulate several aspects of FRDA pathology were constructed and characterized : a model with cardiomyopathy (Puccio et al. 2001), two models with progressive dorsal root ganglia, posterior columns and cerebellar degeneration (Simon et al.,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Computer optimised rotors for internal mixers : an innovative way of enhancing the quality of rubber parts and tyres' in the context of a Fifth Framework call.

assistant: **Objectives**

The present proposal addresses the need for a new generation of machinery in the field of rubber mixing. It is proposed to combine advanced scientific knowledge on rubber mixing and numerical techniques in order to simulate the flow in the mixing machinery and to numerically optimise the geometries of the rotors used therein. The objective is to develop rotors allowing to obtain rubber mixes containing less agglomerates (i.e; incompletely dispersed filler) . It is expected that industrial products made from these advanced mixes will show improved performances: the wear of tyres will decrease by 5 to 10 % and the resistance of technical rubber parts used under extreme conditions (aerospace and off-shore applications) will be improved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Electronic structure and chemical processes in molecules'.

assistant: **Innovation**

Research objectives and content The main goal of the research project is the application of spin-coupled valence bond (SCVB) theory to: (i) The description and understanding of the electronic structure of radicals, and (ii) The study of mechanistical aspects in I ,3-dipolar cycloadditions. (i) There are certain radicals which due to their open-shell electronic structure, are subjected to Jahn-Teller distortions. The detection of conjugated cyclic radicals is difficult, and only the cyclopentadienyl radical (C5H5)- has been detected and spectroscopicaly characterised. It is our goal to perform a thorough study of the electronic properties of the cyclic radicals (C2n+1H2n+1), with n=1,2,3, and assess their Jahn-Teller distortions, using modern valence bond theory. (ii) The electronic structure of the chemical species known as 1,3-dipoles and the characterisation of their cycloadditions are subjects which are still hotly debated within the scientific community. Molecular orbital theory treatments do not give a clear rationalisation of the bonding involved in these molecules. It is nowadays accepted that 1,3-dipolar cycloadditions may occur by either concerted or stepwise mechanisms, but there is no answer on why either mechanism is preferred. Modern valence bond theory with its ready visual interpretation has great promise for solving this and related problems. Training content (objective, benefit and expected impact) The work plan and methods to be used in Bristol comprise using the codes developed by Dr. Gerratt's group, which are able to perform modern valence bond electronic structure calculations on small and medium-sized systems. Visits to collaborators in the group ( Dr. Cooper in Liverpool -UK-, Prof. Raimondi in Milano -Italy-, and Dr. Karadakov in Surrey -UK-) wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Socio economic effects of management measures of the future CFP' in the context of a Seventh Framework call.

assistant: **Objectives**

SOCIOEC is an interdisciplinary, European wide project bringing together scientists from several fisheries sciences with industry partners and other key stakeholders to work in an integrated manner on solutions for future fisheries management, that can be implemented at a regional level. The central concept is to provide a mechanism for developing measures that are consistent with the overarching sustainability objectives of the EU, and that can provide consensus across all stakeholders. The first step will be to develop a coherent and consistent set of management objectives, which will address ecological; economic and social sustainability targets. The objectives should be consistent with the aims of the CFP, MSFD and other EU directives, but they should also be understandable by the wider stakeholder community and engage their support. This will then lead to the proposal of a number of potential management measures, based on existing or new approaches. The second step will be to analyze the incentives for compliance provided by these measures. In particular, we will examine fisher’s responses and perceptions of these measures, based on historical analysis as well as direct consultation and interviews. This project part will also examine how the governance can be changed to facilitate self- and co-management to ensure fisher buy-in to promising management measures. In particular, the project will focus on the interpretation of overarching (i.e. EU) objectives in local and regional contexts. Finally, the project will examine the impacts of the management measures that emerge from this process, particularly in terms of their economic and social impacts. The IA analysis will be integrated by evaluating the proposed measures against the criteria of effectiveness, efficienc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multi-media training on managing user requirements' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The target audience and their needs are: Small Development and Information Systems groups; People who don't have 3 days to spare away from the office; People whose projects are not synchronised with the two events a year when training is available; People whose organisations are too small to justify purchasing in-house training; All organisations who want to train staff exactly when the need arises; Individuals who want to train at their own pace wherever they prefer.The Objectives are to: take a proven, existing set of Managing User Requirements training material and transform it into a prototype multi-media CBT package; do detailed evaluation of the product and its delivery system with 100 people at a mixture of organisations including SME's, non IT sector organisations and larger software development companies; deliver two language versions of this CBT package and demonstrate techniques for further localisation; produce a product that is more cost effective than the current conventional 3-day training event; deliver a product with multiple entry and exit points for use as training material and on-line help; prototype an innovative Internet based delivery and technical support system which will include free demonstration and evaluation copies, on-line discussion groups and technical support.ACTIONSThe Project brings together: Q SET (SPI trainers and software developers); 3Soft (SPI consultants and software developers; Electric Paper (multi-media experts) and Pat Fehin (subject expert in User Requirements). Aside from project management and reporting, the project will have 4 phases; requirements from the market-place; product design; product development; product evaluation. During the project, 100 people will be trained while evaluating the prototype software. In addit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'XCORE: Enabling breakthrough weight reduction for the next generation of cars' (XCORE).

assistant: **Concept**

The main objective of the overall innovation project is to provide a technical solution, XCORE, for cost-efficient production of Carbon Fibre Reinforced Plastics (CFRP) structural components for the automotive industry. This breakthrough innovation enables Europe to create the next generation, low emission and high safety car. European climate policy sets mandatory emission reduction targets for new cars. Car weight reduction with a CFRP chassis is an effective measure to reduce fuel consumption, increase passenger safety and extend electric and hybrid vehicles range. The mainstream automotive industry has not adopted CFRP for chassis production due to the high costs of CFRP production.XCORE has an overall cost reduction of 40% with respect to conventional CFRP manufacturing. XCORE uses an expanding foam with gas filled thermoplastic microspheres in a closed mould to create the high pressure necessary for curing, while conventional production is based on expensive autoclave technology. The key market consists of the car manufacturing companies in Europe, which produce yearly 17.3 million vehicles. The ambition of Donkervoort is a 10% market share of chassis production with XCORE in 2023. The XCORE chassis reduces the car weight with 10 to 12%, resulting in a yearly European fuel consumption reduction of 1.21 billion litres, a cost reduction of EUR 1.17 billion and reduction of 3 billion kilogramme of CO2.In this feasibility assessment the final hurdles will be taken towards an Europe wide market introduction supported by a convincing demonstration with two large car manufacturing companies. The technical feasibility of reducing cycle time and fully automate the production process of XCORE on a commercial scale is assessed. The economic viability depends on substantiatin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Heterogeneous InP on Silicon Technology for Optical Routing and LogIC'.

assistant: **Concept**

HISTORIC proposes to design, develop and test digital photonic integrated circuits containing a relatively large number of active photonic elements combined with passive elements, for use in e.g. all-optical packet switching for both datacom and telecom. The building blocks for the digital photonic circuits are ultra-compact gates based on micro-ring or micro-disk lasers, photonic crystal lasers or metallic nanocavity (or plasmonic) lasers. These lasers are fabricated making use of the heterogeneous integration of InP membranes on top of silicon on insulator passive optical circuits. Different approaches for the ultra compact lasers will be investigated, allowing to make use of the high precision growth and processing techniques available to the InP platform, as well as to take advantage of the extreme accuracy of state-of-the-art CMOS processing.Several all-optical flip-flops and gates will be integrated on a single chip, and will be interconnected by short wire waveguides in the SOI structure. The extremely small dimensions of both the flip-flops, gates and their interconnections will result in a competitive footprint of optical packet switches as compared with electronic switches.The targetted ultra small dimensions of the laser-based all-optical flip-flops are expected to result in record low switching times and switching energies. Together with the low propagation losses in the SOI waveguides, this is expected to result in a competitive speed and power consumption of optical packet switches.The possibility of integrating a large number of photonic digital units together, as well as integrating them with compact passive optical routers such as AWGs, opens new perspectives for the design of integrated optical processors or optical buffers. The project will therefore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated numerical modelling of laser additive processes' under Seventh Framework.

assistant: **Concept**

The processes of laser cladding, deposition and surface alloying are increasingly used in modern manufacturing as surface enhancement, rapid manufacturing, tooling and repair processes. In the simplest terms, they are based on blowing a powder stream into a moving, laser-induced melt pool. Modelling of them is difficult as they are characterised by multiple phase changes and mass and heat flow patterns.  This project will link the Laser Processing Research Centre at The University of Manchester, which is one of the largest laser groups in the UK with expertise in experimental investigation and analytical modelling of these processes, with ESI GmbH based in Germany, a commercial engineering simulation and software development group with headquarters in Paris, France and with expertise in many areas of numerical engineering and thermodynamic simulation. Its aim is to develop integrated software packages to simulate all stages of the processes, including powder conveyance, powder dispersion in the melt pool, melt pool dynamics and track formation and heat flow and stress formation in the substrate. The project is 4-years in length and involves close cooperation for selection of submodels (modelling methodology), coding, sub-models testing, selection of additional process investigations where necessary etc. Additional personnel to aid dialogue and exchange of ideas will be used at stages of the project. The developed models and software packages will aid the increasing number of users of these processes, especially the aerospace industries who demand tight control of them. The models proposed also represent academic advances in this field and can be further developed for microstructure simulation beyond this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Source and efficacy of human olfactory ensheathing cells in the repair of brachial plexus avulsion' (HORAB) targeting Seventh Framework.

assistant: **Abstract**

Olfactory ensheathing cells (OECs) are a unique group of cells which were originally discovered in the olfactory bulb, the part of the brain that receives the sense of smell. These cells have now been found in the nose, and have the potential to encourage damaged nerve fibres to regenerate. When these cells are transplanted into the damaged spinal cords of rats they facilitate repair of the nerve fibres, and this results in an improved ability to climb and breath. It is now possible to obtain these cells from the noses of patients with brachial plexus avulsion (a longitudinal spinal cord injury) and to purify and multiply them for transplantation back into the same patient s damaged brachial plexus, to possibly cure injuries which were previously untreatable. However it is first necessary to find a safe and reliable way to obtain these cells from patients, develop a protocol for cleanroom manufacturing these cells under UK Good Manufacturing Practice (GMP) guidelines, and check whether human cells have the same reparative effects in the laboratory and animal studies, compared to what we already know about rat cells. The research programme consists of the following projects: 1. To develop a protocol for obtaining these cells in optimum quantities, by taking samples from volunteer patients who are undergoing nasal endoscopy for other reasons, and develop an effective culture method to maximise the yield of OECs. 2. To culture these cells under GMP conditions, using standardised reagents, and develop a protocol that ensures the maximum yield in a new culture facility. 3. To transplant autologous OECs into the site of injury in patients with complete brachial plexus avulsion, and assess the safety and efficacy of the technique. This will also allow us to obtain pilot data t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Swarm Intelligence Simulations as Tools for Molecular Design of Better Medicines' to be submitted under Seventh Framework.

assistant: **Abstract**

A new generation of medicines, diagnostics and materials are needed to fuel new advances in healthcare and technology. Critical to this are predictive quality software tools to guide molecular design. In the School of Pharmacy at the University of Manchester, our constant aim is to improve the accuracy of the software tools we use in drug design. The aim of this proposal is to develop a more efficient and accurate software tool for prediction of protein-ligand binding affinities. This tool will use a simple but powerful new evolutionary computing method based on the cooperative behaviour of swarming insects. We have recently shown that this swarm-based approach dramatically improves the conformational optimisation of biomolecules. Now we propose to develop a tool based on a swarm of protein-ligand molecular dynamics (MD) trajectories which provides greater coverage of the high energy conformations, in turn leading to improved estimates of binding free energy. After validation, the tool will be used for predictive lead optimisation to impact our live oncology projects within the Manchester Cancer Research Centre (MCRC) and also in the industrial setting of AstraZeneca. The opportunity to confirm predicted protein inhibitors via synthesis and assay will also be provided.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Reuse of SOLar PV Panels and EV Batteries for low cost decentralized energy solutions and effective Recycling of critical raw MATErials from their EoL products'.

assistant: **Innovation**

Europe is on the need of Critical Raw Materials (CRMs) to secure its green energy transition and achieve climate neutrality by 2050. PV panels for clean energy generation, and batteries for energy storage are key components for the green energy transition but heavily depending on CRMs. However, as the PV and EV markets were developing fast in the last decade in Europe, significant amount of secondary EV batteries, and PV panels will be available for recycling. Traditional approaches that have been used so far for their recycling are focused on materials recovery, and less on the enormous potential for reuse in second life before recycling. Additionally, proposed recycling processes so far are still suffering from several issues related to purity and efficiency of the processes as well as high cost and environmental aspects.  The overarching aim of the SOLMATE project is to set up solid foundations of a new industrial value chain for the sustainable reuse and recycling of PV solar panels and EV batteries in interesting emerging markets and high added value applications. The main objectives of SOLMATE are on one hand i) to develop and demonstrate viable and guaranteed low-cost decentralised energy systems for different emerging markets and business cases based on the reuse of batteries from EoL EV and used PV solar panels (i.e., repowering from PV farms), and on the other hand, ii) to demonstrate low cost and environmentally friendly technologies for improving the purity and increasing the recovery of raw materials (especially critical raw materials) from EoL EV batteries and PV that cannot be reused.SOLMATE is designed to be fully aligned with the “waste hierarchy” principles as indicated in the Waste Framework Directive (Prevention, Reuse, Recycling, Recovery, Disposal)