RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural studies of the catalytic core of the spliceosome' (SNRNP) targeting Sixth Framework.

assistant: **Abstract**

The excision of introns from eukaryotic pre-mRNA and splicing together of exons is performed by a macromolecular machine called the spliceosome. Splicing is a highly dynamic process that involves many spliceosomal intermediates. Each intermediate contains specific RNA-protein complexes called small nuclear ribonucleoprotein particles (snRNPs) and a number of additional non-snRNP proteins. It has been established that the spliceosome intermediates that are involved in the actual splicing reactions contain U2 , U5 and U6 snRNPs and that their snRNA plays a very important role in catalysing the reactions. To date, the crystal structures of a number of components of snRNPs have been reported. Detailed insight into the mechanism of splicing at the molecular level is, however, hampered by lack of structural information of the larger complexes present at the catalytic site of the spliceosome. Therefore I propose to work on those protein-RNA complexes and subsets of intermediates of the spliceosome that are involved i n the catalytic steps during splicing in crystallographic and biochemical studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Next-generation, modular computer mouse device for disabled people' to be submitted under Horizon 2020.

assistant: **Abstract**

About 2.6 million people in Europe have mobility problems affecting their upper limbs, and around 1.3 million of them require Assistive Technologies or the help of human care providers, to be able to perform everyday tasks. Their challenges involve instant access to the physical and digital world. In 2003, we, LIFEtool from Austria, launched IntegraMouse®, a mouth-based computer mouse device in which the buttons are activated by sipping and puffing. In 2011, we upgraded it to our current IntegraMouse®Plus, which serves users with high-level paraplegia, with (partial) arm amputations or progressive diseases such as muscular dystrophy (MD), amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). Our users have helped us to further promote our product thanks to its unique features: a wireless plug&play device that can be set in mouse, joystick and cursor mode. Hygienic utilisation is ensured by a replaceable mouthpiece.Based on our discussions with IntegraMouse users, stakeholders in the market and marketing specialists, we now intend to launch IntegraMouse3 by creating a versatile modular mouse that better serves the variety of our users' needs (professional, gaming, social), while being economic in its production and personalisation: IntegraMouse3. Moreover, novel technical features will be added. Currently, we operate via a network of distributors that have access to potential users and stakeholders. Today with social media in place, we intend to convert our distribution model into a mouth-to-mouth model using social media channels. This will allow us to directly serve our clients, while reducing costs. Combining this new distribution model with the new technical features and the modular system, we expect to create sales of over 6.000 modules, resulting in €5 Mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Functional Lipid−Protein Interactions in Integral Membrane Proteins' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Membrane proteins constitute a third of the human proteome and their relevance to disease has led these proteins to make up more than half of all current drug targets. However, despite this push to identify agents for membrane proteins, the number of established disease-associated targets are limited. The 'open' and solvent-accessible nature of most membrane protein orthosteric sites often results in limited specificity of potential drugs. The Trans-Membrane domains (TMD) while displaying greater variability among membrane proteins were however long considered lacking in specific interactions. But significant developments in experimental techniques are now identifying this domain to interact and be actively regulated by the diverse lipid components of the membrane. This Lipopeutics project attempts to determine if the analysis of the protein's Lipid interactions can be a pathway to the development of allosteric drugs targeted at these bilayer-exposed pockets. Unfolding in three major steps, the project first aims to identify specific lipid binding sites with the TMD through the use of long-timescale coarse-grain Molecular Dynamics simulations. Subsequently, the role of this lipid binding event in the protein's functional modulation is validated through atomistic simulations using the Markov State Modelling approach. Finally, cheminformatic screening is used to design lipid-mimicking compounds that are capable of binding within the hydrophobic pocket and stabilizing specific protein functional states.


**Keywords:** Membrane Protein, Lipid, Ion Channel, Molecular Dynamics, Allosteric, Drug Development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An Integrated Approach for Sustainable Management of irrigated lands suceptible to degradation/desertification' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Soil salinization represents a precondition for desertification, defined as degradation of land in arid, semi-arid and dry sub-humid areas resulting mainly from adverse human impact" (UNEP, 1991). Recent investigations proved that soil salinization and subsequent desertification may be influenced by bypass flow, i.e. the rapid transport of water and solutes via macropores and/or shrinkage-cracks to subsoil and to groundwater. Bypass flow may increase hazard of salinization of subsoil and groundwater, significantly decreasing efficiency of salt-leaching and crop yield. For a proper prediction of hazard of soil degradation and for a sustainable management of irrigated lands susceptible to degradation/desertification, it is therefore necessary to develop and validate management-oriented models accounting for bypass flow. Analysis of the existing physically-based models that can be used for management of irrigated areas susceptible to land degradation/desertification evidences the lack of models accounting for bypass flow. Development of an approach accounting for bypass flow could be achieved by extending the salinity version of the Leaching estimation and Chemistry model LEACHM with modules describing bypass flow of water and solutes. Validation of the extended LEACHM and of the original LEACHM performed through comparisons between predicted and measured values of salinity and sodicity collected in a Sicilian and in a Spanish pilot-areas, will make it possible to check the performance of the original and of the improved version and to assess the relevance of bypass flow on salt-accumulation and salt-leaching under field conditions. A sensitivity analysis will make it possible to select the parameters (climatic, physical, chemical, hydrological) more relevant to the proces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integration of Farm Management Information Systems to support real-time management decisions and compliance of management standards' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In the future European farmers will have to effectively manage information on and off their farms to improve economic viability and to reduce environmental impact. All three levels, in which agricultural activities need to be harmonized with economical and environmental constraints, require integrated ICT adoption: (i) improvement of farm efficiency; (ii) integration of public goods provided by farming into management strategies; (iii) relating to the environmental and cultural diversity of Europe’s agriculture by addressing the region-farm interaction. In addition, the communication between agriculture and other sectors needs improvement. Crop products for the value added chains must show their provenance through a transparent and certified management strategy and farmers receiving subsidies are requested to respect the environment through compliance of standards.  To this end, an integration of information systems is needed to advise managers of formal instructions, recommended guidelines and implications resulting from different scenarios at the point of decision making during the crop cycle. This will help directly with making better decisions as the manager will be helped to be compliant at the point and time of decision making.  In FUTUREFARM the appropriate tools and technologies will be conceptually designed, prototypes developed and evaluated under practical conditions. Precision Farming as well as robotics are very data intensive and provide a wealth of information that helps to improve crop management and documentation. Based on these technologies a new Farm Information Management Systems (FMIS) will be developed. As most relevant farm data will be readily available in the proposed information system, or may be automatically integrated using standardised serv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'New inter-scale techniques for damage analysis of novel composite architectures'.

assistant: **Objectives**

The aim of the proposed research is to develop novel methods of multi-scale analysis for complex architectures obtained with various manufacturing techniques, such as 3D braiding/ weaving, tufting, automatic tow placement, and embroidery. The common feature of these structures is the absence of representative building block at the yarn level. Hence, these composites are not materials in the traditional sense of homogeneous or homogenizable medium. There is no established strategy for accessing the internal stress-strain state and damage in such composites. This challenge will be handled by developing an entirely new multi-scale framework, which constructs the boundary conditions imitating interaction of the meso-volume of interest with the surrounding media. The proposed concept is based on previous studies of textile composites, which succeeded to find a way of handling volumes smaller than representative ones with a fine accuracy.The local meso-scale architecture determines all the aspects of damage accumulation. The methodology aims at defragmenting the medium in accordance to the potential planes of inter-yarn crack propagation. Such a concept can substantially simplify the damage accumulation simulation. The primary focus of the damage modelling is the effect of barely visible damage on component performance. The theoretical developments of the modelling approach will be supported by an extensive multi-scale experimental program. It will be realised through testing of an aircraft component, which is produced by the 3D rotary braiding. The experiments will provide a strong basis for the model validation against surface strains, damage onset, stiffness degradation, damage modes, and crack patterns.Although fundamental in the core, the research has a direct practical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Urban B/ordering: An Ethnographic Study of the Ghetto Package in Denmark' (UrBorder), addressing dissemination and exploitation.

assistant: **Impact**

At a time when migration is increasing, many EU countries still struggle with fully accepting migrants and other minorities. In this context, increasingly, member states introduce laws and regulations that police borders and reinforce social boundaries, and as a result, undermine the idea of liberal democracy. These practices, often labelled b/ordering, constitute attempts to control and order the unknown or undesired subjects. While much literature has dealt with this, it remains understudied how b/ordering works in and through urban planning and housing. The proposed project addresses this lacuna through an interdisciplinary analysis of such a practice of urban b/ordering: the Ghetto Package in Denmark, i.e. a set of laws implemented to break up migrant parallel societies and enforce social mix.The proposed project further develops existing studies dealing with b/ordering by linking three scientific strands of literature: anthropological criminology, urban studies and migration. Methodologically, it will rely on participant observation, focus groups, life-histories, and semi-structured interviews in two different housing areas affected by the Ghetto Package in Denmark. This way, it will complement the existing analyses on the normative and discursive elements of b/ordering with an ethnographic account of its implementation and social and political consequences. Likewise, focusing on an iconic liberal democracy like Denmark will elicit knowledge on potential societal effects regarding citizenship and belonging in the EU. Academically, the project will benefit from the placement at the University of Copenhagen, the prominent research centre, the Centre for Global Criminology, and a Secondment at the inspiring research environment at the Amsterdam Institute for Social Sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi Fuel Operated Integrated Clean Energy Process: Thermal Desorption Recycle-reduce-reuse Technology' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Develop efficient energy conversion process with overall design efficiency improvement >3% as compared with the unit as operated before retrofit-Improve environmental performance by preventive pre-treatment and removal of HAP. Removal of organic S, Cl>95%, Hg>99% and by use of clean fuel decrease GHG emission with >20% compared to best available technique. Decrease total production cost by >10 % below the cost of technologies that are in operation. Recycle/reuse the removed S, whereas production of by products will be capable of obtaining economic values greater than by products produced with any known technical solutions. Increase feed flexibility for different types of high S content coal and renewable biomass, providing net thermal efficiency on any co-used multi fuel of >65 %. Improve expanded use, EU dimension acceptability of renewable biomass and use waste vegetable oils for CC impregnation for safe/near zero emission clean energy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bioengineered hippocampal organoids for epilepsy treatment' (NEUROTILES) under Horizon 2020.

assistant: **Objectives**

Epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure); it carries among the highest burden of disease and significant social stigma. Temporal lobe epilepsy (TLE) is the most frequent syndrome, the least responsive to medications and the most linked to severe psychiatric and cognitive co-morbidities. When drug resistance ensues, neurosurgery and deep-brain stimulation are invasive options to carefully consider. Thus, TLE treatment demands urgent innovative interventions. Is it possible to generate ‘replacement parts’ to heal the diseased brain? The idea of repairing the brain using engineered transplants is nowadays more appealing than ever thanks to the ground-breaking advent of ‘mini-brains in a dish’ (brain organoids). Remarkably, brain organoids can be derived from human stem cells, thus carrying unique potential for targeted studies. However, their application in regenerative medicine has yet to thrive. Therefore, the interaction of brain organoids with mammalian brain tissue remains unexplored.In this project, I engage in the challenge of generating surrogate brain areas as transplants for epilepsy treatment. Specifically, I will focus on the hippocampus, a central structure in learning and memory which is crucially involved in TLE. I will push an unprecedented biohybrid design based on the synergetic exploitation of organoid technology and innovative neural engineering tools to pursue, for the first time ever, the establishment of a dialogue between engineered and mammalian brain tissue. The foundation of NEUROTILES stems in the emerging concept that brain repair strategies from regenerative medicine and neural engineering are distinct yet complementary. In the era of artificial intelligence and nanotechnology, NE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanomechanical spin-to-photon transduction in silicon' under Horizon 2020.

assistant: **Concept**

The spin of an electron trapped in the binding potential of a phosphorous donor has recently shown some of the longest quantum coherence times in solid state and is now regarded as one of the most promising materials for quantum computing. However, current readout techniques rely on single-electron transistors for which millikelvin temperatures and nanoelectronic connections are needed. We propose to establish a new transduction mechanism that coherently couples silicon spin qubits to optical photons at the quantum level and hence provides optical addressing at 4K temperatures. Central to our proposed quantum transducer is a nanomechanical resonator, that acts as a conduit of quantum information. We will realize sufficiently strong interactions between the resonator and both spins and photons by exploiting nanophotonic systems, which can confine light fields and mechanical motion at the nanoscale. Our objectives are to show: (i) coupling between the spin and the mechanics by inducing spin-dependent mechanical frequency shift and read this out optically, and (ii) pulsed backaction-evading measurements of nanomechanical motion, establishing a fast single-shot qubit readout method, and allowing the creation of non-classical mechanical states through projective measurement. Doing this we create a unique three-way hybrid quantum system: spin qubit–mechanical resonator–optical cavity. The study of this new “spin-optomechanics” system is expected to both contribute to the exploration of the size-frontiers of quantum mechanics and lead to advancements in the field of quantum computation as well as ultra-sensitive magnetometry. The project allows the applicant to gain crucial expertise in nano-optomechanics and nanophotonics. Combined with his previous experience on spin qubits,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Spin current induced ultrafast switching'.

assistant: **Innovation**

The SPINSWITCH MCRTN project integrates the efforts of 15 leading European Groups including some from the New Member States and Associated Countries to explore the scientific foundation and the potential of the spin transfer effect, in particular for high frequency and ultra-fast switching applications, and to train ESRs and ERs for the future scientific work force. SPINSWITCH will focus on a limited number of well-defined, specific, scientific tasks concerning fundamental understanding and to advance technical applications. A strong team-working approach will be used linking fundamental studies, modelling/theory, advanced characterisation and work on model structures for applications. Several fundamental device geometries will be explored using supply chains a cross the network including film deposition, patterning, advanced characterisation as well as theory and modelling. Strong links to SIEMENS and THALES, industrial research laboratories, and to INESC-MN and IMEC, major applied research centres, will promote the work on devices and provide industrial guidance. Several partners have unique analytical techniques and capabilities of fundamental importance to the measurements of the new structures to be developed. SPINSWITCH will provide comprehensive, state-of-t he-art scientific and complementary training for at least 17 network researchers. Transfer of Knowledge will be given special emphasis: between the research centres, to researchers especially from the NMS and AC and to industry. A summer school held in Romania, a ToK workshop in Poland, a special course on entrepreneurship (supported by network 'linked' SMEs) and special training for members from the NMS are features of the SPINSWITCH RTN. The SPINSWITCH RTN will integrate 15 partners from 8 Member States and