RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Proton versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The aim of PROTECT-trial is to compare the clinical outcome of proton therapy (PT) and conventional radiotherapy in a randomized study and to use the data and experience to advance the field of evidence-based medicine in PT. A randomized trial with 396 patients is planned involving 13 recruiting units and 34 institutions from nine European countries in an accrual period of three years. All involved PT centers have state-of-the-art equipment, including pencil beam scanning and volumetric image guidance. The endpoints will include side effects, tumor control, survival, and health economics aspects. PROTECT-trial will use experience from the trial, combined with parallel experience from other trial methodologies, to create a consensus model for the selection of patients both for referral for standard PT and for enrollment in clinical trials. This model will be based on esophageal cancer but will have wider implications, which can be used in all European countries and for other cancer types. PROTECT-trial will result in new evidence for the role of PT in cancer management. PROTECT-trial will advance the quality of care for trimodality management of esophageal cancer. The large trial will provide statistically robust results at a high level of clinical evidence and will allow a successful trial to trigger an international change in clinical practice. If the PROTECT trial is positive, PT will become a standard option for a large patient population. The patients will recover faster from their treatment and live a better life with fewer side effects and more years at work. The results will have high relevance for other cancer types where protons also lower the dose to sensitive normal tissues. Notably, PROTECT-trial will actively engage with patients, providers, payers, and oth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Building an Intelligent System of Insights and Action for 5G Network Management' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

5G will realise a true Internet of Things, a network capable of supporting potentially trillions of wireless connected devices and with overall bandwidth one thousand times higher that today’s wireless networks. Current 4G technology is approaching the limits of what is possible with this generation of radio technology and to address this, one of the key requirements of 5G will be to create a network that is highly optimised to make maximum use of available radio spectrum and bandwidth for QoS, and because of the network size and number of devices connected, it will be necessary for it to largely manage itself and deal with organisation, configuration, security, and optimisation issues. Virtualisation will also play an important role as the network will need to provision itself dynamically to meet changing demands for resources and Network Function Virtualisation (NFV), the virtualising of network nodes functions and links, will be the key technology for this.We believe that Autonomic Network Management based on Machine Learning will be a key technology enabling an (almost) self administering and self managing network. Network software will be capable of forecasting resource demand requirements through usage prediction, recognising error conditions, security conditions, outlier events such as fraud, and responding and taking corrective actions. Energy efficiency will also be a key requirement with the possibility to reconfigure the NFV to for example avail of cheaper or greener energy when it is available and suitable. Again this is directly related to usage prediction both at a macro level, across an entire network, and at a micro level within specific cells.The Cognet proposal will focus on applying Machine Learning research to these domains to enable  the level of Ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Generic regularity of area minimising hypersurfaces and mean curvature flows' (GENREG), addressing dissemination and exploitation.

assistant: **Impact**

Major advances in geometry and topology have been achieved by studying critical points and gradient flows for natural energies, but these analytic methods are hindered when singularities occur. In fact, singularities are the main obstacle in the use of area minimisation in the proof of the positive mass theorem up to dimension 7 and the use of Ricci flow with surgery in the proof of the 3-dimensional Poincaré conjecture. A key observation in geometry and physics is that generic solutions, obtained by small perturbations, can exhibit simpler singularities or even none at all. This phenomenon, called generic regularity, can yield outstanding results. The recent generic regularity breakthroughs by the PI-led group will allow to address fundamental open problems in three areas: For area-minimising hypersurfaces, we aim to extend generic regularity to all dimensions, building on the PI's work in up to 10 dimensions. This would establish the positive mass theorem in all dimensions, bypassing technical analysis of the singular set of minimisers. It would also allow the resolution of other well-known problems related to scalar curvature. For mean curvature flow singularities, which are unavoidable, generic flows are expected to encounter only the simplest types. Work of the PI has proven this in 3 and 4 dimensions up to the problem of “multiplicity”. Bamler–Kleiner recently excluded multiplicity in 3 dimensions. Our goal is to prove that multiplicity generically cannot occur in higher dimensions. This would mark major progress towards the Schoenflies conjecture, a main open problem in 4-dimensional topology. For special Lagrangian submanifolds, fundamental objects in symplectic geometry, we would geometrise Lagrangians in Calabi-Yau manifolds by establishing generic Lagrangian
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel approaches towards the diagnosis and therapy of tumours with microsatellite instability.' under Fifth Framework.

assistant: **Concept**

A large percentage of tumours from hereditary non-polyposis colon cancer (HNPCC) patients, as well as more than 15% of sporadic colon tumours, display micro satellite instability (MSI) , which has been linked to a defect in mismatch correction (MMR) . Tumour cells with high MSI (MSI-H) differ from other cancer cells: they are largely diploid and the oncogenes and tumour suppressor genes mutated in them are frequently different from those altered in sporadic disease without MSI. We shall compare the response of normal and MSI-H cells to a series of chemotherapeutic and radiomimetic agents, as well as to ionising and non-ionising radiation. The principal aim of this program is to exploit the identified differences in cancer therapy, by devising ways of selectively killing cells with MSI. The second goal of the study is to use our findings to develop new, facile, diagnostic strategies for the identification of at-risk individuals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genetic vaccination with allergen-derived constructs human and animal models' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content climate change and climatic variability on agriculture in Europe. Research will follow two main themes: i) the advancement of fundamental research on mechanistic crop-climate modelli and (ii) the development of methodologies for scaling up site-based crop models to investigate climate change impacts on regional cropping systems. A number of aspects of this work distinguish it from previous or current efforts. Firstly, current crop-climate research will be extended by developing new mechanistic crop models, improving the performance of existing crop models in extreme elimatie conditions, considering elimate change impacts on yield quality as well as general erop physiology and identifying the strehgths and weaknesses of crop models based on inter-model comparisons. Secondly, the development of methods for applying mechanistic crop models at a hierarchy of scales will ensure a full evaluation of the effects of elimate change on regional, national and continental agricultural production. Effects on regional cropping systems will be modelled to identify sensitive areas and assess the sustainability of agricultural systems across Europe. Thirdly, a wide array of downscaled regional scenarios of combined changes in mean climate and climatic variability will be constructed using the latest transient general circulation models and high resolution limited area model experiments for Europe. A stochastic weather generator will be used to translate the GCM output into a form suitable for application with regional scale mechanistic crop models. Finally, a spatially integrated framework will be developed to aid scenario construction, model development and analysis/comparison of results. This will enable cross-sector and trans-European evaluations of cl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Organizational responses in the presence of corruption' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objective of this proposed project is to analyze certain aspects of corruption, when such contractual relationships have to be self-enforcing. The sustainability of a self-enforcing corrupt relationship depends on the amount of information the involved parties have about each other. Hence, when evaluating the effectiveness of anti-corruption policies one should consider how they affect the flow of information between the involved parties, i.e. they might facilitate or garble informational flows. Such considerations might be important especially when the informational flows generated by the interactions among corrupt parties are localized, while the implemented policies affect uniformly the entire population. Moreover, corruption may create inertia that hinder the adoption of beneficial organizational innovations, especially when the agents of an organization can not be forced to implement them. To the extent that such innovations reduce corruption opportunities, their adoption might meet opposition which is too costly to buy-out". "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Organizational self-renewal - process design' under Fourth Framework.

assistant: **Concept**

The research explores how organisational renewal is affected in organisations. Particular emphasis is hereby placed on processes. A series of in-depth studies in British and German companies are developed and relevant processes mapped using an knowledge-based diagramming tool providing the empirical data base. The data of the individual companies is compared to test the theoretical models and related hypothesis. Organisations in different phases of growth and in different business sectors are deliberately chosen, assuming that organisational processes are similar regardless of these factors. It is assumed that the similarity of processes is determined by the necessity and nature of organising information and work flows. However it is assumed that differences in the processes as well as in the number of interconnections and of feedback loops exist when comparing high and average performing organisations. The individual models are compared to identify possible patterns that can be linked to the level of organisational performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'THERAPEUTIC ARCHITECTURE FOR CANCER: MIXED METHODS ANALYSIS OF BUILT ENVIRONMENT INFLUENCES ON OLDER PATIENTS’ WELLBEING IN CANCER OUTPATIENT INFUSION CLINICS' (THERARC) targeting Horizon 2020.

assistant: **Abstract**

The proportion of the number of people aged 65 years and over compared to the younger population is steadily increasing in Europe. To accommodate growing healthcare needs, at least three European countries recently allocated a budget of €477 toward the building of new healthcare facilities. With age, the incidence of cancer greatly increases. Cancer is one of the primary causes of morbidity in Europe, with more than 3 million new cases yearly. Moreover, cancer patients’ experience of mental and physical fatigue, and anxiety is more pronounced due to the ageing process. Costly cancer medicine and research address the treatment of illness, yet the socio-spatial therapeutic qualities of cancer clinics, a fundamental aspect of health, remain an overlooked element of healthcare provision. Medical and architectural researchers recognize the therapeutic role of the built environment, yet primarily focus on patients’ needs in inpatient wards. Research in outpatient clinics has been scarce, even though the transient nature of outpatient clinics often fails to support fundamental socio-spatial needs such as privacy, territoriality and accessibility. Articulation of how the built environment of care, particularly outpatient cancer clinics, can support older patients’ wellbeing lacks interdisciplinary perspective. The scientific objectives of this project are a) exploration of the spatial elements that influence multifaceted needs of older cancer patients through ethnographic, quantitative research and gender analysis; b) the establishment of an interdisciplinary theoretical foundation based on medical sociology, environmental psychology and built environment studies. Articulating the spatial determinants of healthcare provision for the older population increases their survival rat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identifying the Needs of Medical First Responder in Disasters' under Seventh Framework.

assistant: **Concept**

Identifying the Needs of Medical First Responder in Disasters (NMFRDisaster) is a project coordinating medical first responders with research institutes in order to identify need for further research in the following areas:  1) Training methodology and technology used to train medical first responders for disasters. 2) Understanding the human impact of disaster on first responders. 3) Ethical and legal issues influencing the medical response to disasters. 4) Personal Protective equipment used in Chemical and Biological incidents. 5) Use of blood and blood products in disasters. This will be achieved through a preliminary research on existing know how followed by a work shop where the needs of the first responders will be identified, matched with existing knowledge and products, then setting the roadmap for future needed R&D.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unravelling the role of the immune receptor CD300f in spinal cord injury and metabolic reprogramming' to be submitted under Horizon 2020.

assistant: **Abstract**

Inflammation after spinal cord injury (SCI) exerts a key effect on the progress of both degeneration and regeneration after a traumatic injury. In addition, it has become increasingly clear that understanding the interaction between metabolism and immune function can provide an insight into cellular responses to different challenges. Recent reports from our group and others, suggest that metabolic reprogramming and immune receptors play an orchestrated role in modulating microglia and macrophage phenotype. An interesting example is CD300f, a very unique immune receptor that: i) displays a dual activating/inhibitory capacity; ii) is important for the phagocytosis of apoptotic cells and putatively of synapses; and iii) regulates microglia immunometabolic phenotype. Our hypothesis postulates that, by modulating immunometabolism, CD300f plays an important role in neuroprotection under neuroinflammatory conditions. In the current project, we propose to addresses the interplay between inflammation and metabolic reprogramming by evaluating the role of microglia/macrophage CD300f and their metabolic reprogramming after SCI. We will also test the efficacy of a mitochondrial modulator as a novel neuroprotective strategy for the stimulation of microglial mitochondrial oxidative metabolism.This proposal is based on a set of unpublished data produced by both the ER at the Institut Pasteur Montevideo and the host institution. We will use novel tools generated by our group as the CD300floxP mice, that crossed with CX3CR1-Creert mice will enable to the conditional CD300f KO in microglia and barrier macrophages, and compare these results with global KO mice. The results generated will provide novel insights related to the mechanisms underlying SCI, and for the understanding of how the i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developing the Next Generation Framework for Testing Nonlinear Dynamic Structures.' (TNS), addressing dissemination and exploitation.

assistant: **Impact**

When designing new structures and devices, engineers are completely dependent on mathematical models to ensure that their designs function as intended. As technological boundaries are pushed to the limits, systems become nonlinear – the response of the system is no longer proportional to the input. These nonlinear systems can exhibit a wide range of complicated behaviour that is very difficult to predict and potentially disastrous. Take for example the F-117A Night Hawk stealth jet. Despite extensive modelling and design work, at an airshow in 1997 in Maryland, Essex, USA, it encountered a disastrous instability known as flutter. The aircraft was lost. Until now there has been no general-purpose systematic method that can directly measure and characterise nonlinear dynamic behaviour during laboratory tests; hence it is extremely challenging to incorporate nonlinear features into the model development and validation process.Control-based continuation (CBC) is a systematic method designed to fill this void in the nonlinear test and measurement field. Thought the method has already been demonstrated on several simple mechanical systems, it is still in its infancy and lacks robustness. The specific objectives of the research proposed here are to develop and incorporate in CBC effective and noise-robust algorithms and control strategies, hence leading to a solid and more general framework for testing nonlinear dynamic systems. The method will be demonstrated experimentally including on an aeroelastic rig that exhibits potentially dangerous flutter-induced limit cycle oscillations in a wind-tunnel.


**Keywords:** Nonlinear Dynamics,  Vibration,  Testing,  Continuation Techniques
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'IcoCell− Chassis for Enhanced Mammalian Cell Line Development and Engineering' (IcoCell) targeting Horizon 2020.

assistant: **Abstract**

The opportunity to focus on the production of biopharmaceuticals is often taken from SMEs since huge amount of resources is required for the development of high-producer cell lines. We envision that our parental cell factories will increase the efficiency of cell line engineering and will effectively reduce the time-to-market for mammalian cell-based products. It allows SMEs to leverage their traditional strengths of adaptability and creativity, and to develop novel products for biotechnology industries.