RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated evolutionary analyses of genetic and drug interaction networks in yeast' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The ability of cellular systems to adapt to genetic and environmental perturbations is a fundamental but poorly understood process both at the molecular and evolutionary level. There are both physiological and evolutionary reasonings why mutations often have limited impact on cellular growth. First, perturbations that hit one target often have no effect on the overall performance of a complex system (such as metabolic networks), as perturbations can be adjusted by reorganizing fluxes in metabolic networks, or changing regulation and expression of genes. Second, due to the fast evolvability of microbes, the effect of a perturbation can readily be alleviated by the evolution of compensatory mutations at other sites of the network. Understanding the extent of intrinsic and evolved robustness in cellular systems demands integrated analyses that combine functional genomics and computational systems biology with microbial evolutionary experiments. In collaboration with several leading research teams in the field, we plan to investigate the following issues. First, we will ask how accurately genome-scale metabolic network models can predict the impact of genetic deletions and other non-heritable perturbations. Second, to understand how the impact of genetic and drug perturbations can be mitigated during evolution, we will pursue a large-scale lab evolutionary protocol, and compare the results with predictions of computational models. Our work may suggest avenues of research on the general rules of acquired drug resistance in microbes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mitigation of climate induced natural hazards (MITCH)' (MITCH).

assistant: **Concept**

MITCH will bring together the various research institution and user representatives, including insurers, with a leading involvement in the mitigation of natural hazards with a meteorological cause. The aim will be to assist planning and management for these events, by evaluating the state of research, and to match that with both users perceptions and needs as to what the research community can provide. A primary focus of the CA will be on flood forecasting and warning, but it will also include other flood related hazards, such as landslips and debris flow. It will also look at longer-term climate hazards, such as drought, and the possible impact of climate change on the frequency and magnitude hazards. The CA will be conducted through a series of 5 workshops and an active website for exchange of views and evaluation of best practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Contributions of muscle mechanics and sensorimotor control to agile locomotion' to be submitted under Horizon Europe.

assistant: **Abstract**

Humans and animals navigate complex terrain seemingly effortless. This is in stark contrast with even the most performant robots, illustrating that walking over complex terrains is by no means trivial. Our neuromusculoskeletal system is equipped with mechanisms that allow us to recover from unexpected perturbations. Two key mechanisms are muscle intrinsic mechanics and sensory-driven feedback control. Immediate changes in muscle force upon a perturbation allow the body to respond fast to sudden perturbations through quick-acting muscle mechanical responses. Feedback responses, slower due to transmission delays, are also critical to stability as they are more flexible whereas muscle mechanical responses are determined by feedforward control and muscle properties. We do not yet know how these pathways interact to help us maintain agility and robustness, in the presence of external perturbations, or in the case of sensory loss. I aim to gain novel insights into how muscle mechanics and sensory feedback allow agile locomotion across conditions. I will unravel fundamental principles governing relative contributions of these mechanisms, using a blended experimental- and computational approach. I already collected a unique experimental dataset that I will combine with physics-based simulations. I will use novel approaches to predict locomotion patterns and feedforward and feedback control by optimizing performance criteria in presence of sensorimotor noise without relying on experimental data. Validation of simulation to experimental data allows us to evaluate which performance criteria and muscle properties drive observed interactions between muscle mechanics tuned by feedforward and feedback control. As many neurological disorders impair stable locomotion, fundamental insigh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Construction with unbound road aggregates in Europe' (COURAGE), addressing dissemination and exploitation.

assistant: **Impact**

In summary the objectives of the project are:- To extend and deepen the understanding of the fundamental mechanical behaviour of unbound granular materials.- To provide a means of characterising this behaviour in a manner suitable for application in pavement design and performance prediction, partly by developing appropriate models.- To attempt to validate this description with real pavement performance data.- To apply the knowledge gained to develop better materials and better methods of use.- To draft the consequent findings in a manner appropriate for European pavement design and maintenance personnel. %The demonstration sites are expected to be: - Finland-VT 4 in Northern Finland - Finland-2 no. TPPT National test roads - Iceland-to be determined - Ireland-to be determined - Portugal-Experimental test road IC1 - Slovenia-National test road - France-Full scale accelerated experiment at LCPC Nantes %There is a very close linkage with the work of the COST 337 Action Collaboration with the 3rd Call Transport RTD project called ALT-MAT" as well as national research efforts."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Linkage between genome stability and checkpoint control' under Fifth Framework.

assistant: **Concept**

The preservation of genome stability is an essential process in every living organism. DNA can be damaged by a variety of agents and in a number of ways, often with deleterious consequences to cell survival. To prevent such consequences, DNA damage triggers a multitude of responses in eukaryotic cells, including DNA damage signaling and repair, and delay of cell cycle progression until repair is complete. This latter response is referred to as the DNA damage checkpoint". If this checkpoint fails for any reason, genome instability can result. In higher eukaryotes, this can lead to cancer, accelerated ageing and/or certain neurodegenerative disease states. In this application, a set of complementary genetic and biochemical approaches are proposed for the study of the linkage between genome stability maintenance and checkpoint control. The nine laboratories in the proposed network will use biological systems that will allow the efficient integration of these complementary approaches. The main objectives to be addressed are briefly summarized as follows: - To understand the molecular function of DNA helicases involved in the preservation of genomic stability in yeast and humans. These helicases include S. cerevisiae Sgs 1 p, Srs2p, Dna2p, Mph1p, and the human XPB, XPD, BLM and WRN proteins - To establish how the activity of DNA repair and recombination proteins is controlled by checkpoint proteins The achievement of these objectives will allow the network to define the functions and interactions of the different components of the DNA replication, repair and recombination machineries and to understand the regulatory circuits connecting these processes with checkpoint control. This information is a prerequisite to obtaining a complete insight into cellular growth control and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CHEESE TEXTURE IMPROVEMENT THROUGH RATIONALISATION & OPTIMISATION OF STRUCTURE' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the TIROS project is to provide the cheese manufacturers with the way and means to control the texture of soft cheeses, specifically through cheesemilk preparation.To reach this goal, a three step approach is considered.- First, it is necessary to understand the effects of the major milk preparation techniques (e.g. standardisation, prematuration, heat shocked starters, ...)  on the coagulation and draining processes.  This requires : - to quantify the impact of milk modification at the level of molecular interactions and of microstructures; - to understand the formation of the continuous texture by elucidating the mechanisms of curd grains fusion; - to describe through a mathematical model the migration of water and solutes at the different stages of the cheese process.- Texture sensory analysis of ripened soft cheeses will be related to the physical properties and the microstructural characteristics of the finished products.- The information acquired through the two first steps and pilot scale cheese production will allow to build up a predictive model of soft cheese texture as a  function of milk and technological treatments. The TIROS project is multidisciplinary and involves both specialists in technology (IE, FR) and in cognitive sciences (BE, FR & SE). The coordination will be assumed by an industrial company with a strong experience in research project management. The outcomes of the TIROS project will cover domains ranging from basic sciences to economical developments. The most significant advances in fundamental dairy sciences will be a curd grain fusion theory, a mathematical model of water migration during the soft cheese process, and a predictive model of soft cheese texture.Moreover, the knowledge acquired through the TIROS project with bovine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Learning and PREdiction based on the PREnatal CONnectome FInGerprint'.

assistant: **Innovation**

Endeavours towards a more profound understanding of the neural architecture enabling the staggering cognitive abilities of the human brain hold high promises regarding diagnosis and treatment of various diseases affecting the neural system. The novel paradigm of brain connectomics has opened a wealth of insights into the individual differences, emergence, development, plasticity and disease specific re-organization of macro-scale brain networks composed by interconnected and synchronously operating neural units.Fetal neuroimaging, and in particular fetal magnetic resonance imaging (MRI) provides increasingly rich insights into the rapid prenatal neurodevelopment shaping the human connectome and establishing its capability to enable cognition or adapt and re-organize during disease. However, the exploration and study of this complex, highly multi-dimensional connectivity architecture, and its rapid change during gestation is still hampered by several limitations. PRECONFIG aims to overcome these limitations by developing novel techniques for the reliable and accurate capturing of structural and functional MRI brain connectivity in utero and integrating them into a quantitative model providing a complex feature-set that characterizes the developing fetal connectome (""fetal connectome fingerprint""). Ultimately, the project will deliver a canonical reference model, and algorithm implementation for artefact removal, brain network development modelling and detailed characterization of developmental disorders based on fetal MRI. Additionally it will provide a standard basis for reproducible and comparable research targeting the fetal connectome. Based on this, it will provide a proof-of-concept on the expediency of computational statistics and machine learning based stratifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Future of manufacturing in europe 2015-2020 - the challenge for sustainable development' in the context of a Fifth Framework call.

assistant: **Objectives**

The European Commission wishes to ensure that European manufacturing industry in 2015-2020 will be highly competitive. Therefore, regardless of its profile and structure, there are particular factors that can be influenced and analysed, in order to bring such desirable situation about. The project will develop a major prospective mapping of three critical general capabilities and competencies - Technology, Knowledge and Skills, Organisation and Business capabilities, necessary to underpin a sustainable and competitive European manufacturing industry in the future. This will result in critical contributions to policy strategies including; dematerialisation of products through miniaturization, new materials, localized networks of production based on principles of industry ecology, product stewardship, closed loop production recycling and remanufacture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Simplifying the SNAP-ADAR Tool for Broad Usage in Life Science Research and Drug Discovery' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

RNA base editing is a promising approach to manipulate genetic information in a transient and dosable way, which breaks new ground in basic Life Science research and drug discovery. In a preceding ERC CoG action, we have engineered the SNAP-ADAR tool, which allows for the particularly precise, efficient and programmable adenosine-to-inosine RNA base editing. However, the broad usage of this tool is somewhat hampered by the need for designing the chemically modified guideRNAs, which currently includes some peptide bond-forming chemistry and nucleic acid gel purification. In this PoC action, we aim to simplify the tool to make it available for a larger section of the Life Science community. Specifically, we aim to simplify the chemistry and the compounds to such an extent that a SNAP-ADAR kit is obtained, which enables the Life Scientist to perform the required chemistry without special equipment or chemistry skills. Furthermore, the kit would include a reliable and simple protocol to perform efficient and precise editing reactions in mammalian primary cells. Profit could particularly be generated from the selling of the chemically stabilized guideRNAs. We envision that the product would find application in the modulation of protein function like signaling cues and metabolic pathways and may foster the target screening and target validation in drug discovery efforts, which are currently ongoing in the field of RNA base editing. The action also contains an analysis of the IP landscape and - at the later stage of the action - we aim to involve industrial partners for commercialization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Traces of contact: Language contact studies and historical linguistics'.

assistant: **Objectives**

This project aims to establish criteria by which results from language contact studies can be used to strengthen the field of historical linguistics. It does so by applying the scenario model for language contact studies to a number of concrete settings, which differ widely in their level of aggregation and dime depth: the languages of the Amazonian fringe in South America, the complex multilingual setting of the Republic of Suriname, the multilingual interaction of immigrant groups in the Netherlands, and two groups of multilingual individuals. New methods from structural phylogenetics are employed, and the same linguistic variables (TMA and evidentiality marking, argument realization) will be studied in the various projects. In the various projects, use will be made from a shared questionnaire, so that comparable data can be gathered. By applying the scenaio model at various levels of aggregation, a more principled link between language contact studies and historical linguistics can be established.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A reliable, effective ballast water management system through unique in situ biocide production', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The transfer of invasive species via ballast water in shipping is a continuing threat to biodiversity and human health.  The International Maritime Organization (IMO) state untreated ballast water is the second biggest environmental issue after global warming, causing damage of ~$100 billion p.a globally. To address this, recent IMO legislation requires all vessels to fit an approved Ballast Water Management System (BWMS) by 2024. Ship builders and operators are thus seeking compliant BWMS which also meet operational needs such as high efficacy, reliability and low operating costs. Unfortunately, current products, mostly based on Ultraviolet and Electrochlorination, suffer from poor disinfection and low reliability. In fact, almost half of all installed systems are not operational or not performing to standard at any given time, according to The American Bureau of Shipping and major ship owners. Emerging technologies such as Boron Doped Diamond (BDD) electrochlorination can dramatically increase efficacy but suffer from delamination and clogging caused by the byproducts of electrolyzing seawater. Innovative wastewater treatment specialist Atana has developed XCell, a unique patent-protected electrochlorination cell to resolve issues in current state of the art systems. It uses novel, structured BDD electrodes which deliver a 40% more efficacious, non-corrosive product, Hydrus75, which is used and trusted globally.Our objective is to transfer this technology to exploit the market opportunity in the BWMS sector. Production is currently shore-based and we need to demonstrate on board production to the marine market. This Phase 1 project will validate the market opportunity for XCell in the ballast water sector and confirm our potential to generate cumulative revenues of €9
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European financial systems in post-crisis recovery' to be submitted under Horizon 2020.

assistant: **Abstract**

FINSYS RECOVERY i) provides a detailed view of how European financial systems (FS) evolved in the period 2005-2020;  and ii) quantitatively investigates how shocks in the shape of crisis events (e.g. the global financial crisis, the EURO crisis and the COVID-19 pandemic) and related policy responses influenced FS trajectories across European countries in this period. The project seeks to generate new ways of understanding FS and their transformations by drawing on an interdisciplinary framework based on financial economics, political economy and corporate governance. By regressing panel data on macroeconomic outcomes and policy responses of different crises on an innovative country-based FS metric, it applies methods that are uncommon in research on FS. The FS metric enables the construction of a spectrum of FS across countries that can be tracked over time. This, in turn, allows for looking beyond the extant literature’s dichotomous conceptualization of FS as either bank- or market-based. In addition, it sheds light on issues that are often neglected in FS research, such as the role of cross-border listings or borrowing and the role of non-bank financial intermediaries. By using a large European panel dataset, the project seeks to generate new insights on the direction, speed and lag by which shocks influence FS. FINSYS RECOV thereby complements earlier research that typically focuses on how outcomes of shocks vary between different FS, or case-based research on how select small numbers of FS have responded to particular shocks.Generating insights on how FS respond to shocks, and if EU FS are converging or diverging, could hardly be timelier. There are ongoing political initiatives to promote deeper integration of EU FS, while at the same time counterfactors such as Br