RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Identification of early disease markers, novel pharmacologically tractable targets and small molecule phenotypic modulators in Huntington's Disease''.

assistant: **Objectives**

Huntington's is a devastating neurodegenerative disease with many unmet patient needs. There are no known ways of slowing or preventing the neuro-degeneration, and clinical trials in man are hampered by the slow disease progression and the absence of suitable biomarkers of short-term progression. The genetics of HD is characterized, and involves the expansion of a polyglutamine tract at the amino-terminus of the Huntington gene (HTT). However, the translation of this knowledge into therapeutic and diagnostic approaches is hampered by the scarce knowledge of HTT biology, the paucity of information on how cellular signalling pathways interact with the HD mutation, and the lack of systematic and modern approaches aimed at identifying useful bio-predictors of disease progression in individuals diagnosed with HD. The proposal addresses key areas of HD patient need, namely the discovery and development of therapeutically meaningful novel targets and biomarkers. To achieve these aims, this consortium representing complementary and specific know-how and expertise which will be integrated and further developed in the course of the project. High throughput-RNAi, focusing on genes encoding pharmacologically tractable proteins rather than on a whole-genome approach, will be employed on a novel and robust HD cellular disease model to identify proteins whose inhibition of expression is protective against the HD mutation. Following a stringent target validation approach, two such validated targets will be selected for assay development and primary screening activities, to identify druggable compounds active on the target and efficacious against the HD mutation in cellular disease models. In parallel, the biomaterial repository made available to the consortium from a disease-specialist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Future Connectivity and Digital Infrastructure'.

assistant: **Innovation**

The WA3.1 FCDI project aims to specify and develop the future Technologies coming from the CNS in order to support and manage the Operational Services, like the 4D Trajectory Management, in the future ATM System. Performance requirements for CNS systems are becoming increasingly complex and demanding and need to be considered as part of an integrated and holistic System of Systems, which includes air and ground CNS solutions considering convergence towards a common infrastructure, and a unified concept of operations, where possible. In parallel, CNS systems and infrastructure for both airborne and ground must take a more business- and performance oriented approach with efficient use of resources delivering the required capability in a cost-effective and spectrum efficient manner. The R&I results will enable the full implementation of concepts such as infrastructure as a service to facilitate the complete decoupling of service provision (infrastructure services, information services and all other ANSs) from the physical location of the infrastructure, as outlined in the target architecture specified in the European ATM Master Plan (R&I need: enabling the deployment of a performance-based CNS service offer).


**Keywords:** Datalink, LDACS, IPS, Interoperabilty, HyperConnected ATM, Multilink, FCI, Cyber Security, Space Based CNS, VOICE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reinforcement of the Adult stem cell research are through Mobility and Scientific networking between Egypt, Romania and a German consortium for Strengthening the international scientific competency' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

INTRODUCTION. RAMSES comprises partner institutions from Germany (FMC), Romania (ICBP) and Egypt (CU) in order to promote closer S&T cooperation opportunities between Europe and Egypt. The concept of RAMSES is to build capacities by improving scientific relationships, networking and development of the S&T Human Potential, exchanging of know-how and experience between the participating partners, as well as by upgrading the S&T research capacities of CU. RAMSES partners will channel their expertise to complete the proposed objectives by 6 highly interlinked work packages.OBJECTIVES. Exchange of scientific know-how and experience will be implemented primarily via trans-national secondments of research staff.Reinforcement of human resources and infrastructures will focus on the increase of research quality, visibility and competitiveness of CU.Workshops, conferences and training events for knowledge sharing network building will facilitate knowledge transfer at national & international level. Hands-on, Advanced, and “Multiplier” workshops will allow a robust transfer and sharing of acquired skills & experience.Dissemination and promotional activities will provide maximum support for management, dissemination, promotion, and exploitation of project outcomes.Evaluation will monitor RAMSES’ progress to ensure its structured implementation.Consortium management & assessment of progress and results will aim at implementing strong management structures in order to coordinate the different activities.RELEVANCE. Through these objectives, RAMSES will establish networking conditions that will allow the promising CU the opportunity to develop a partnership through twinning actions with EU Centers of Excellence and to realize its full research potential. These shall contribute to regio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Anticipating the Network of the Future - From Theory to Design' in the context of a Seventh Framework call.

assistant: **Objectives**

Future networks became a central topic with a large debate whether moving towards the new networked society will be evolutionary or disruptive. In the future networked society the physical and the digital worlds will merge based on the massive usage of wireless sensor networks. Objects will be able to identify and locate themselves and to communicate through radio interfaces. Self-organized edge networks will become more and more common. Virtualization and programmability will allow for providing different networking environments over the same infrastructure.  Autonomic networking will deal with the increasing complexity of IandC systems. End-users empowerment will increase with his capacity of providing services and content, as well as connectivity support.This new environment forces the scientific community to develop new principles and methods to design/dimension/control/manage future multi-technology architectures. The new paradigms raise new challenging scientific and technological problems embedded in complex policy, governance, and worldwide standards issues. Dealing with the diversity of these scientific and socio-economic challenges requires the integration of a wide range of research capacities; a role that Euro-NF will fulfil.Indeed, Euro-NF extends, in scope and duration, the successful Euro-NGI/FGI NoE that has integrated the required critical mass on the networks of the future and is now a major worldwide player in this area. The consortium has evolved in order to have an optimal coverage of the new scope. Euro-NF will therefore cover the integration of a wide range of European research capacities, including researchers and research and dissemination activities.  As such Euro-NF will continue to develop a prominent European center of excellence  in Future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Morphology dynamics and propagation of extragalactic relativistic jets' (1994-1998).

assistant: **Concept**

Numerical simulations have become an important tool in understanding th morphology and dynamics of extragalactic jets. However, despite the evidence of relativistic bulk motions in these jets, simulations have traditionally been performed in the frame of classical fluid dynamics.  The project aims the study of several aspects of the morphological and dynamical properties of jets using relativistic hydrodynamical simulations. It is the natural sequel of my previous two-year training grant.  The study includes the last part of the analysis of a large sample of relativistic jet models with the objective of determining the dependence of the jet properties on the relevant initial parameters (particularly the internal beam Mach number and beam flow speed). The project also considers the performance of more realistic simulations in which the propagation of the jet through a decreasing atmosphere is followed along several decades of the beam radius.  Finally, and in combination with an accurate procedure for the integration of the transfer equations of the synchrotron radiation, I will continue the study of the emission from parsec-scale jets. The main goal is now to model the superluminal components observed in VLBI jets as the result of perturbations evolving along the jets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European School of DNA Nanotechnology' (ESCODNA) targeting Seventh Framework.

assistant: **Abstract**

DNA Nanotechnology is an emerging interdisciplinary area that will underpin the development of future nanoscience-based technologies for areas such as medicine, diagnostic tools, optics and electronics. DNA nanotechnology is based on the unique self-assembly properties of DNA which allow the rational design and synthesis of complex nanoscale structures with predictable form and function. Many other materials can be integrated in such DNA structures to create highly functional nanodevices. The Marie Curie ITN EScoDNA will establish a sustainable European School of DNA Nanotechnology. By providing high quality training to young scientists, EScoDNA will improve their career prospects in both public and private sectors; it will also strengthen the competitive position of European research and industry in this promising strategic field. A network of leading European researchers, two SMEs and a major commercial research institute will work together to foster the development of a new generation of scientists with the skills required to meet future challenges in DNA nanotechnology, from fundamental science to novel applications. The training program will involve collaborative research projects, including international secondments and exchange of data through a web-based Lab-Wiki Journal, and through summer schools and workshops. The industrial partners will be integrated in the training programme, and the two SMEs will coordinate training related to the commercial exploitation of new technologies, management and entrepreneurial skills. They will also take a lead in managing the protection and commercialization of new technologies arising from research with the ITN. The programme is designed to create a pool of highly qualified researchers prepared for a wide range of careers in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Investigation of adaptive design and rewiring of Survival-Apoptosis-Mitogenic (SAM) signalling transduction network' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cell life is not the property of any single protein or gene; rather it emerges from concerted actions of multiple molecules in cellular networks. Current proposal is focused on Signal Transduction Networks (STN) connecting the environment to cell responses. A major challenge is to understand how STN integrate and process environmental signals in a robust and reliable way and how they “compute” cell fate decisions depending on genetic background. To answer this question, the study will be focused on three interconnecting STNs: the Survival (PI3K/PTEN/AKT), Apoptotic (RASSF1/MST/LATS) and Mitogenic (EGFR/RAS/RAF/MEK/ERK) pathways, the SAM network. In the scope of current proposal the methods of signalling network reconstruction will be improved and the SAM network topology will be reconstructed in the panel of cell lines. Based on available data and reconstructed network topology the mechanistic site-specific dynamic model of SAM network will be developed and validated. Model predictions of dependence of signalling outputs behaviour on different perturbations (like small molecule inhibitors and their combinations) and background (mutations and protein expression levels) will be validated. The signalling outputs will be experimentally correlated to the cell fate decisions.The developed models will relate mutational information to treatment responses in the context of different expression landscapes and they will explain and predict mechanisms of intrinsic and acquired drug resistances, which often cannot be picked up by only intuitive reasoning. During the project the applicant will get training in a range of modern computational modelling, biochemical and molecular biology techniques used to study intracellular signalling networks. As a result, he will acquire skills of e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Power in international trade negotiations' (TRADEPOWER) targeting Horizon 2020.

assistant: **Abstract**

For the last twenty years, countries across the globe have negotiated a large number of preferential trade agreements. In parallel, trade negotiations have taken place in the framework of the World Trade Organization. These negotiations not only deal with tariffs, but also cover investments, competition policy, labour standards and much more. With much at stake, the extent to which different countries are able to achieve their preferred outcomes in these negotiations is of broad interest. In this project, I address this topic by asking: what makes some countries have more bargaining power than others in these negotiations? In other words, what explains variation in bargaining power in trade negotiations? My approach to these questions is ground-breaking in terms of theory, empirical research and methodology: 1.) I develop an original theoretical argument that links the globalization of production to bargaining power in trade negotiations. Concretely, I argue that the offshoring of production reduces the importance of market size in trade negotiations. The argument leads to the expectation of systematic variation in bargaining power over time, and across pairs of countries and sectors.2.) I will collect novel and systematic data to test this argument, going far beyond the empirical evidence currently used to assess bargaining power in trade negotiations. The empirical research will bring together qualitative evidence from case studies with quantitative evidence on both the perception of power and the actual outcomes of trade negotiations. 3.) I will innovate methodologically by combining and comparing three approaches to measuring bargaining power, namely process tracing, attributed influence and preference attainment.The project will make a key contribution not only to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional analysis of a new class of mads box genes in arabidopsis' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The project deals with a new class of MADS box proteins that were identified in Arabidopsis using the data of the genome sequencing project. The phylogenetic analysis shows that these proteins belong to the SRF-like type of the eucharistic MADS box regulatory factors, which are characterised by different conserved a residues in the MADS box and different structural features in the C-terminal part of the protein when compared to known plant MADS box proteins. The project aims to functionally analyse these new type of MADS box genes, concretely the representatives of the ALG29 and AGL30 clad. Arabidopsis plants will be transformed with over expression, RNA interference (for repression of a transcript) and VP16-GR fusion constructs. Transform ants showing interesting phenotype will be further molecularly and morphologically characterised. An Arabidopsis transposing population, available to the group of Dr. L. Colombo, will be screened for insert ional mutants in the genes of interest. For the selected candidates an experiment will be performed, using the VP16-GR Arabidopsis transform ants and the micro array, to identify target genes. The yeast two-hybrid system will be applied to identify a part of the protein responsible for dimidiation (by a deletion study), and the three-hybrid system to analyse a possible ternary complex formation amongst the new MADS box proteins. If one of these genes shows to have an interesting agronomical trait, it will be used to transform rice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Implementation of a metric based quality management for software development process'.

assistant: **Concept**

The motivation for performing the experiment was to improve the status of the engineering practice. With respect to process engineering, measurement and control of the software development process is not sufficient. Errors in the software development process are often found too late within the product development or its life cycle. This significantly affects the time and costs for product development itself. The objective of the experiment is to develop and establish a metric system to be implemented in the software development process in order to improve the quality (i.e. reliability, performance, maintainability and safety) of our products. Additionally, the transfer of the results within the wider European Community will be achieved by appropriate publications.THE EXPERIMENTTo achieve the objective above, the following methods and tools will be applied in the experiment:Data collection plan. This will be used for comparison, evaluation and verification of metrics.Metric tools. Tools which are suitable to collect metrics for evaluation process quality and software product characteristics.Quality management. Quantitative measurement of the quality of the software development process. The metric system will be designed module scaleable for projects of different size and complexity.The experiment will be performed around a baseline project, in this case a measurement equipment for general purpose measurement of components for advanced digital communications systems. The baseline project team consists of 12-15 engineers involved with the development of hardware and 15-20 engineers developing the associated software.EXPECTED IMPACT AND EXPERIENCEThe definition and analysis of the software development process by the introduction of metrics, including the creation of a compr