RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Swift COronavirus therapeutics REsponse' (SCORE) under Horizon 2020.

assistant: **Objectives**

Coronavirus 2019-nCoV has become a worldwide public health emergency, and the lack of vaccines and drugs to immediately address this outbreak is painfully clear. Even if the epidemic can be stopped, the virus may return in the same or a modified form. More than vaccines and therapeutic antibodies, antiviral drugs can target highly conserved viral functions and have the broad-spectrum activity that is critical to combat current and future outbreaks. Since the 2003 SARS outbreak, as leading academic coronavirus researchers, we have collaborated to understand and inhibit coronavirus replication. We defined viral key functions, developed tools for inhibitor screening, and identified/engineered drug candidates. Until 2015, our collaborative efforts were supported by the FP7 SILVER project, but they have been continued until this very day. As European coronavirus experts, we now propose the SCORE project, supported by a leading pharmaceutical company. Virologists, biochemists, structural biologists, and medicinal chemists will collaborate in a state-of-the-art drug discovery/design program that targets 2019-nCoV. Our vast SARS-CoV-derived expertise and unique toolbox will be a major asset to achieve immediate impact.We will target the virus using 5 independent approaches: (i) using of (combinations of) FDA-approved drugs, (ii) targeting viral RNA synthesis, (iii) inhibiting coronavirus proteases, (iv) blocking virus entry, (v) discovery and development of new antivirals. This program will be supplemented with 2019-nCoV toolbox and animal model development. We aim to deliver proof-of-concept for selected compounds within 6-9 months, after which they will be offered for further use/development. This will contribute to short-term solutions for the on-going crisis and also pave t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Europe’s Rail Flagship Project 2 - Rail to Digital automated up to autonomous train operation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

To meet the increasing demand for transportation of both passengers and freight, FP2-R2DATO will take the advantages of digitalisation and automation to develop the Next Generation ATC and deliver scalable Digital and Automatic (up to Autonomous) Train Operation (DATO) capabilities in order to enhance the capacity of the existing rail networks. Tangible results of FP2-R2DATO are expected to be delivered by 2025 on key topics: ATO, ETCS Hybrid level 3 and Level 3 Moving Block, digital technologies (5G-connectivity and a standardized onboard ICT-platform), and guidelines and methods for fast and cost-effective deployment and migration of DATO throughout Europe. Through these technical improvements FP2-R2DATO will meet the objectives and impacts defined in the ERJU Master Plan and Annual Work Program: contribute to increased punctuality, reliability and productivity of staff, rolling stock and infrastructure. FP2-R2DATO will pay attention to potential risks, such as acceptance by the public, synchronising with ETCS-deployment and potential legal issues, The overall methodology FP2-R2DATO uses to achieve the desired results is set-up along three stages: from the development of technical enablers, via prototypes that lead to dedicated demonstrators at TRL 6/7. The collaborative approach of industry suppliers, railway operators, infrastructure managers, together with research centres and academia FP2-R2DATO will ensure that each of the technical enablers will be developed at a reasonable cost and will match operational requirements as well as integration innovative technologies. Feedback loops are organised to align research centers, suppliers and railway operators throughout the project, to ensure the technology developed creates the impacts aspired towards a future digitise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'AbRASIVE PARTICLE ORIENTATION BY ELECTROSTATIC MEANS'.

assistant: **Innovation**

In making tooling involved in the production of very high accuracy engineering components, abrasive particles have to be positioned into pre-formed moulds which themselves are of extremely high accuracy. Currently the particles are hand placed into films of adhesive applied to the mould, but its inconsistent thickness leads to inaccuracies of the finished product between 2 and 5 Microns. By avoiding the use of a preapplied adhesive film and positioning the abrasive particles directly on the mould surface the accuracy can be improved by an order of magnitude. The research required will investigate the electrostatic properties of various particles and surfaces and develop the technology for achieving optimum deposition. Selected combinations of electrostatic and mechanical forces will be assessed. Mathematical modelling of the system performance will be derived and this model will then be tested by experimental assessment. In making tooling involved in the production of very high accuracy engineering components, abrasive particles have to be positioned into pre-formed moulds which themselves are of extremely high accuracy. Currently the particles are hand placed into films of adhesive applied to the mould, but its inconsistent thickness leads to inaccuracies of the finished product between 2 and 5 Microns. By avoiding the use of a preapplied adhesive film and positioning the abrasive particles directly on the mould surface the accuracy can be improved by an order of magnitude. The research required will investigate the electrostatic properties of various particles and surfaces and develop the technology for achieving optimum deposition. Selected combinations of electrostatic and mechanical forces will be assessed. Mathematical modelling of the system performance will be d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Raman Endoscopic Proteo-lipidomics of Bladder Cancer'.

assistant: **Concept**

The goal of ENDOMICS is to drive forward a new paradigm of Raman endoscopic technology that enables proteomic and lipidomic analysis for diagnosis of bladder cancers in vivo. Raman endoscopy is a label-free optical technique that can provide a point-wise vibrational molecular fingerprint of tissue “optical biopsy” for cancer diagnosis in vivo. State-of-the-art Raman endoscopy, however, does not offer specific compositional analysis or insights into molecular biology of tissue. This is because the vibrational Raman bands are overlapping and cannot be deciphered into the myriad of biomolecules in complex tissue.      We will introduce a ground-breaking new methodology to enable Raman proteomic and lipidomic analysis in vivo. To this end, heterospectral co-registered Raman and mass spectrometry imaging will be used to develop a multivariate regression model “Rosetta Stone” for translating vibrational structural information (Raman spectroscopy) into compositional information. To meet the unmet clinical needs in urology we will tailor the first fibre-optic Raman endoscopic technology that can measure depth-dependent molecular profiles to simultaneously enable detection, grading and staging of bladder cancers. We will finally conduct a clinical trial by applying the technique to measure a comprehensive molecular database of bladder pathologies in vivo. The latter will allow for the identification of proteomic and lipidomic biomarkers to develop novel algorithms for real-time diagnosis of bladder cancers.     The synergy between scientific and technological advances in ENDOMICS will break ground for shedding new light on the molecular biology of bladder cancer in vivo including new insights into clinical diversity and identification of biomarkers for diagnostics, prognostics a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Infrared Imaging Components for Use in Automotive Safety Applications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective of ICU is to develop the core photonic components for a Far Infrared (FIR) camera module aimed at high volume automotive Night Vision Enhancement Systems (NVE) of the future. FIR imaging provides a high-contrast signal for warm (living) objects. This makes FIR systems very attractive for the detection of living objects and thereby helping to reduce fatalities and injuries. However, the cost of FIR NVE for automotive use must come down significantly to enable high volume fitment rates. At the same time they need to be capable of detecting a person from a distance of up to 120 m.The photonic components developed in ICU include an infrared lens system, an infrared bolometer array, a wafer-level vacuum package and the component assembly. The infrared components are matched to achieve optimum cost and performance. The functionality of the individual photonic components can be evaluated in a combined system or alternatively independent of each other.The essential novelty in ICU are infrared bolometer arrays made of a new, mono-crystalline SiGe/Si quantum well material, providing increased temperature coefficient of resistance (TCR) and improved 1/f noise properties as compared to state-of-the-art infrared bolometers. The bolometers will be manufactured using heterogeneous 3D MEMS integration that is compatible with standard MEMS foundry services. A low-cost wafer-level vacuum packaging process will be developed that can consistently achieve vacuum levels in the sealed cavities on the order of 0.001 mbar. Infrared optics will be developed that can be mass manufactured using low-cost processes and lens material. The system will be the first application of multilevel diffractive optics in FIR, with the added feature that the optics can be integrated in the package
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nanoscale-enhanced Spectroscopies in Electrochemically-Gated Single-Molecule Devices' (TECh-MoDE).

assistant: **Concept**

To push forward Molecular Electronics, a complete understanding of the nanoscale molecule/electrode interface is a must, since the interactions, structure and electronic characteristics of such interfaces define their physicochemical properties, thus their functionalities. This knowhow will enable exploiting these interfaces as the building blocks for the next generation of high performance and sustainable electronic devices. With the aim to decipher the abovementioned big unknowns, TECh-MoDE will develop the first hybrid platform with spectro-electrochemical detection capabilities of individual molecules under ambient conditions: the EC-TERS/Blinking, which will be based in the communion of two platforms: first, the Scanning Tunneling Microscope Break-Junction will allow to capture the tunnelling current through an individual bridged molecule between two electrodes of Tunneling nanoscale gap, enabling the electrical signatures of a single-molecule electrical contact. Second, the TERS, a high ultrasensitive non-destructive spectroscopic method, will provide spectroscopic features of the trapped molecule under strict electrochemical control. The single-molecule nature of this new platform provides a detailed insight into the molecular junction structure by simultaneously capturing current flow and vibrational spectra during the spontaneous formation of a molecular junction. This state-of-the-art dual-platform will allow to study, for the first time, the evolution of spectro-electrochemical characteristics in a molecular junction. This novel platform will be then exploited to explore several key structural aspects that remain unknown during the formation of single-molecule electrical contacts: (1) the observed multiple contact configurations in most common covalent anchor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Establishment of P-element silencing in Drosophila simulans dysgenic males' to be submitted under Horizon 2020.

assistant: **Abstract**

Transposable elements (TEs) are mobile genetic parasites infecting the genomes of most organisms, so abundantly as to be a major determinant of genome size in eukaryotes. They can be harmful, as their ability to mobilise makes them highly mutagenic and a threat to host genome integrity. Hence, organisms have evolved several TE repression mechanisms, especially in the germline, where new mutations can be transmitted to progeny. TEs challenge these silencing strategies by invading new genomes through horizontal transfer, but hosts appear to rapidly adapt to these new TEs. The classic example is the invasion of the Drosophila melanogaster genome by the P-element: TE repression in this system evolved so quickly that the P-element and its repressors (recently discovered to be due to a small RNA pathway) appeared almost simultaneously. The selective pressure may have been intense: crosses between D. melanogaster males containing P-elements and females devoid of it lead to frequent F1 sterility and other aberrant traits. This phenomenon, associated with uncontrolled P-element mobilization, is named “hybrid dysgenesis”. Due in part to its rapidity, little is known about the early stages of TE repression evolution. In this work, we propose to take advantage of a rare opportunity to study the adaptation to a TE invasion in real time. Less than a decade ago, the P-element invaded the genome of D. simulans, a sister species of the genetic model. We aim to disentangle the molecular mechanisms involved in the establishment of P-element silencing in D. simulans. In particular, we will study the effects of dysgenesis and repression in males, which have been largely neglected to date. As a result, their role in the rapid spread of the P-element remains elusive. This work will contribute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Real time monitoring of SEA contaminants by an autonomous Lab-on-a-chip biosensor' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Early warning systems that can provide extreme sensitivity with exquisite selectivity are required to assess chemical contamination of estuarine and coastal areas. SEA-on-a-CHIP aims to develop a miniaturized, autonomous, remote and flexible immuno-sensor platform based on a fully integrated array of micro/nano-electrodes and a microfluidic system in a lab-on-a-chip configuration combined with electrochemical detection for real time analysis of marine waters in multi-stressor conditions. This system will be developed for a concrete application in aquaculture facilities, including the rapid assessment of 8 selected contaminants from 5 groups of compounds that affect aquaculture production (compounds which are toxic, bioaccumulative, endocrine disruptors) and also those produced by this industry that affect environment and human health (antibiotics and pesticides), but it is easy adaptable to other target compounds or other situations like coastal waters contamination analysis. Each device will be able to perform 8 simultaneous measures in duplicates and it will be build in order to work with one-month autonomy and measuring in real time at least once per hour. As many devices as needed could be connected simultaneously to the same platform resulting in a very flexible and inexpensive system. Sensitivity for Sea-Water analysis is guaranteed thanks to the use of gold microelectrodes arrays with metalocarborane doped functional polypyrrol. Thank to the use of MEMS and microlectrodes in flexible polymeric substrates the costs of production will be reduced. The units will be tested throughout the lifetime of the project and calibrated to state-of-the-art of chemical analytics: first in laboratory studies, second under artificial ecosystems and finally during 3 field experimen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Colloidal control of multi-phase flow in geological porous media' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The COCONUT project aims at developing predictive capabilities to understand how colloids (nanometals, fine particles, bacteria, viruses, asphaltenes..) control immiscible two-phase flow in complex geological formations. Colloids (including nanoparticles) have an incredible potential to remobilize non-aqueous phases trapped by capillary forces in soils and the subsurface, and then to remediate contaminated groundwater or to enhance oil recovery. Their use in daily engineering, however, is still underexploited because the lack of knowledge regarding their transport mechanisms is an obstacle to precise control of two-phase flow. Importantly, the presence of colloidal particles flowing in the subsurface challenges the standard modeling viewpoint of flow and transport based on Darcy's law. We posit that the precise control of colloids on the motion of two-phase flow can only be achieved by developing a deep knowledge of the coupled hydro-electro-chemical processes at the pore-scale. The COCONUT project uses a combined modelling-experimental strategy focusing on the pore-scale mechanisms and on the upscaling to the continuum-scale. The project is multi-disciplinary and uses computational and experimental sciences, fluid dynamics, electrochemistry, and mathematics. The project will require the development of hydro-electro-chemical computational models at different scales of interest (WP1). We will use high-resolution simulations to interrogate emergent physico-chemical processes and characterize the surface attractive and repulsive forces at the nanoscale (WP2). Then, we will decipher the mechanisms leading to the displacement of fluids trapped in an unsaturated porous medium in the presence of colloids using pore-scale modelling and microfluidic experiments (WP3). Finally, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Future High-Altitude Flight - an Attractive Commercial Niche?', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The objective is to identify and assess the long-term potential of commercial high-altitude flight in Europe for selected mission requirements, in view of the activities in the USA following the successful SpaceShipOne demonstration. Furthermore, it is proposed to identify for Europe missing developments in technology and address safety measures as well as needed steps to satisfy legislation.A corresponding research and development strategy to enable commercial high-altitude flights will be worked out in order to secure the international competitiveness of European industries. While the common understanding of the European community is that the sub-orbital high-altitude flight is technically feasible within a few years, building on the available knowledge in aviation, it has never been proven experimentally.The USA has achieved with SpaceShipOne an air-launched X-vehicle, which, however, will require significant effort before becoming a commercial, routinely used transport vehicle. Such sub-orbital flight is also understood to be on the borderline to space, since the transport of people is approaching the orbital environment without really entering it fully in the sense of having to master the harsh environment of hypersonic re-entry into the atmosphere.According to reports the interest in the USA in high-altitude flying is very large in spite of the high price, suggesting a profitable niche for commercial flight and triggering innovation in small industries to satisfy such demand.Key objectives are hence1. assess worldwide activities and define reasonable mission requirements2. identify potential show stoppers, technical but in particular non-technical ones, and missing elements for carrying out commercial high-altitude flight3. propose a way forward to achieve commerc