RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Glycolytic contribution to cancer growth and metastasis' in the context of a Seventh Framework call.

assistant: **Objectives**

Cancer lethality is most often associated to occurrence of distant metastases. To grow and become aggressive, cancers may undergo 2 critical adaptations: the glycolytic switch, corresponding to uncoupling glycolysis from the tricarboxylic acid (TCA) cycle, and the angiogenic switch, promoting neovascularization. In this high risk/high gain research program, we propose that the glycolytic switch precedes and promotes angiogenesis and metastatic dissemination in most types of cancer. We further envision that lactate, the end product of glycolysis, interfaces glycolysis and the latter processes through activation of hypoxia-inducible factor HIF-1. A thorough characterization of the molecular pathway(s) initiated by lactate (using transcriptomic, gene silencing, enzymatic and pharmacological interventions) has the potential to unravel new therapeutic targets that would simultaneously inhibit the consequences of the glycolytic switch on cancer aggressiveness. We anticipate the plasma membrane lactate transporters of the (sodium) monocarboxylate transporter (S)MCT family to be key determinants of autocrine and paracrine lactate signaling in cancer. Modulation of their activity or expression (notably by the generation of (S)MCT knock out mice) could thus profoundly affect tumor angiogenesis and metastasis. Since hypoxia is a hallmark of cancer and glycolysis its direct consequence in cancer cells surviving to hypoxia, the findings could have important consequences for the treatment of virtually all types of cancers. It could also impact our understanding of other pathologies, such as wound healing and heart infarction, in which the interplay between glycolysis, HIF-1 activation and angiogenesis could play a critical role.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Vascular Endothelial interactionS and SpEciaLization' (Vessel), addressing dissemination and exploitation.

assistant: **Impact**

The vascular network plays essential roles in animal biology. Local disruption or impaired function of the vascular network is known to cause various pathological conditions, such as ischemic heart disease and stroke. The angiogenic growth of blood vessels is critically required during development, growth and regeneration, but it can also promote the growth of cancer cells and contribute to diabetic retinopathy and other diseases.  Various blood vessels possess different biological characteristics in order to fulfil their tissue- and organ-specific roles. The VESSEL network brings together 12 academic and industrial partners with a common interest in morphogenesis of blood and lymphatic vessels and their role in tissue homeostasis. This training program covers major research areas from embryonic development of blood and lymphatic vessels, to the analysis of their structural integrity and function in various adult tissues in normal and pathological conditions, and aims to address critical demand to provide state-of the-art training for future specialists in vascular biology working in academia, industry and health care systems. By employing cutting edge innovative technologies, this project establishes strong bonds between academic and industrial partners and has a strong potential to generate new IP in this area. This project has a strong clinical relevance based on gaining insight into critical vascular biology processes and on developing novel cutting edge imaging and drug delivery technologies. Through cooperation of the different Centres, the VESSEL consortium will develop integrated, highly specialized, curricula for young scientists, which will open new career perspectives in academia and industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Science without Empire: Science, Medicine, Scientific networks and the Danish Halle Mission in the Danish East Indies, 1770-1845' (SCINET).

assistant: **Concept**

The project investigates the construction of science, medicine and scientific networks in colonial India in the period ca. 1770-1845 from a new perspective: the Danish Halle Mission and the Danish East Indies. Resent research has recognised that science and medicine were not neutral elements in the colonization but were used by the colonial powers to gain control of both the inhabitants and the environment of the colonies. However, the diffusion of science and medicine was not unidirectional from the European metropoles to the colonial peripheries. The production and spread of the so-called “colonial sciences”, which had a profound impact on the development of western society, was a much more complex process in which European and indigenous actors in the periphery had great significance. The colonised inhabitants often succeeded in reinterpreting and utilizing western science and medicine for their own purposes. The project will investigate these issues through four main objectives: - To establish all scientific and medical activities in and networks via the Danish East Indies in the period. On this basis to determine which groups participated in science, how they participated and what the intentions were behind their participation. - To investigate the networks connecting the scientific agents in the Danish East Indies to similar individuals and organisations in other parts of India and the rest of the world. On this basis to determine (using the method of Social Network Analysis) how these networks were structured and functioned. - To compare the characteristics of the scientific activities and network in the Danish East Indies with similar activities and networks based in other European colonies in India. On this basis to reveal the characteristics and results of ‘Sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Using mathematical methods as tools for evaluation of dynamic process in regions' under Fifth Framework.

assistant: **Concept**

The main objective of the proposed project is to develop new mathematical tools based on the mathematical statistic, theory of information and fuzzy logic for the evaluation of developing of the regions. The aim. of this evaluation will be multi criterial analysis of changes in the period of last ten years. The concept of sustainable development" will be focused inside of analysis. The methods will be practically evaluated on selected regions The focus of this evaluation will be on combination of geographic, demographic, environmental and social - social economical aspect. The evaluation will be provided in the period of last ten years."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Single-cell sequencing analysis of striatal gene regulatory networks in Parkinson's disease' (PARKSEQ), addressing dissemination and exploitation.

assistant: **Impact**

Parkinson’s disease (PD) is the fastest growing Neurodegenerative disorder, currently affecting an estimate of 7 to 10 million people worldwide. The disease is characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of protein aggregates in the remaining ones. The loss of these cells leads to a dopamine deficit in the striatum which causes the motor symptoms characteristic of PD and the general malfunction of the neuronal circuitry in the basal ganglia. The existing treatment for PD is dopamine replacement therapy with levodopa. This drug alleviates the motor symptoms but has a number of side effects, loses efficacy with time and does not address the cognitive decline caused by PD. In order to gain a better understanding of the disease and open new paths towards an effective treatment, the PARKSEQ project will use the latest advanced in single-cell RNA sequencing and in situ hybridization to determine which cell-type specific gene regulatory networks (GRNs) are affected by PD in the striatum. To this end, I will use single-cell RNA sequencing (scRNA-seq) to study post-mortem human striatum samples from PD and control subjects, under the supervision and guidance of Ana Muñoz, a leading expert in PD and scRNA-seq studies. I will draw from my experience in Bioinformatics and in single cell data analysis to determine the cell types and subtypes existing in the human striatum. On each subtype, I will establish which genes are differentially expressed and, considering their co-expression, I will formulate putative altered GRNs. Then, during a secondment period, I will join Mats Nilsson laboratory to validate the scRNA-seq findings using in situ hybridization. Dr. Nilsson has advanced this technique making it possible to use verify the pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Iron homeostasis in c. reinhardtii : impacts of the up and down regulation of ferritin on gene expression and chloroplast proteome levels' (1998-2002).

assistant: **Concept**

We aim to investigate iron homeostasis in the model organism C. reinhardtii. Ferritin, a 24-multimeric complex involved in iron storage and located in the chloroplast, is a key component to regulate iron intracellular concentration. We first will construct strains that over or under express ferritin. For this we will take advantage of the existence of a ferritin cDNA, that will be inserted in both orientations under the control of an HSP70 promoter. Nuclear transformation will allow the insertion of the constructs into the genome of a recipient strain. We will compare the phenotype of the resulting strains with wild-type strains grown under different iron concentrations I mainly at two levels. The expression of certain genes that are known to respond to iron concentration will be investigated by Northern Blot. The chloroplast protein content will be monitored by two-dimensional gel electrophoresis, and proteins that display a differential expression will be analyzed by mass spectrometry. Protein network involved in chloroplast iron homeostasis or ferritin regulation will then be identified. Our goal is to dissect ferritin function in chloroplast relevant and in general aspects of iron homeostasis. The proposed research project will allow me to develop new competencies on the Biochemistry of the model organism C. reinhardtii (chloroplast proteome analysis by 2D electrophoresis and mass spectrometry, protein complex purification using FPLC). I will also learn nuclear transformations which complete my experience in chloroplast transformation. I think that having a broad and integrated knowledge on many aspects of C. reinhardtii Biology will be a great advantage in my carrier. The host group will take benefit of my strong background in Molecular Biology and my knowledge in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Improving Models for Marine EnviRonment SErvices' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The overarching goal of IMMERSE project is to ensure that the Copernicus Marine Environment Monitoring Service (CMEMS) will have continuing access to world-class marine modelling tools for its next generation systems while leveraging advances in space and information technologies, therefore allowing it to address the ever-increasing and evolving demands for marine monitoring and prediction in the 2020s and beyond.In response to the future priorities for CMEMS, IMMERSE will develop new capabilities to: - enable the production of ocean forecasts and analyses that exploit upcoming high resolution satellite datasets,  - deliver ocean analyses and forecasts with the higher spatial resolution and additional process complexity demanded by users,  - exploit the opportunities of new high performance computing (HPC) technology - allow easy interfacing of CMEMS products with detailed local coastal models. These developments will be delivered in the NEMO ocean model, an established, world-class ocean modelling system that already forms the basis of the majority of CMEMS analysis and forecast products. Hence the pathway from the research in IMMERSE to implementation in CMEMS will be simple and seamless, as the model code developed will be directly applicable in CMEMS models. NEMO has a long track record of producing and maintaining a stable, robustly engineered code base of the type that is needed for operational applications, including CMEMS. The IMMERSE consortium combines world-class expertise in ocean modelling, applied mathematics and HPC, established software engineering processes and infrastructure, and in-depth knowledge of the CMEMS systems and downstream CMEMS systems. Thus IMMERSE is exceptionally well placed to deliver the operational-quality model code required to meet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Cocombustion of biomass and fossil fuels (FB-COMBUSTION)'.

assistant: **Objectives**

One of the possibilities to cut down environmental effects of energy production with fossil fuels is to partly replace coal with biomass. Combining biomass with coal full-scale boilers for electricity eneration (cocombustion) could lead to a high energy-efficiency utilisation at comparatively low investment costs. One of the main problems in cocombustion of coal and biomass is the increased deposit formation and corrosion due to increased concentration of chlorine and alkalis in the fuel mixture. The alkalis originating from the fuel ash contribute to deposit formation during the cocombustion. The increased reactivity due to increased content of volatiles in the fuel blends may promote alkali release from coal in the flame thus strengthening the deposit formation even if the contents of alkalis, chlorine and sulphur were not high in the biomass. The increased mineral content in the fuel blends 'originated from biomass) may also promote fouling. At the moment FB boilers are the most advantageous burner systems due to their ability to burn wide assortment of fuels and still provide reduced emissions. The temperature in a fluidised bed is lower that in pulverized fuel combustion and efficient combustion is achieved by a relatively long residence time in the bed. Because of the relatively low temperature, the thermal NOx formation is not a problem in FB. The fellows will in their work concentrate on - cocombustion of biomass and fossil fuels - deposit formation and - corrosion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multi-modal Context Modelling for Machine Translation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Automatically translating human language has been a long sought-after goal in the field of Natural Language Processing (NLP). Machine Translation (MT) can significantly lower communication barriers, with enormous potential for positive social and economic impact. The dominant paradigm is Statistical Machine Translation (SMT), which learns to translate from human-translated examples.Human translators have access to a number of contextual cues beyond the actual segment to translate when performing translation, for example images associated with the text and related documents. SMT systems, however, completely disregard any form of non-textual context and make little or no reference to wider surrounding textual content. This results in translations that miss relevant information or convey incorrect meaning. Such issues drastically affect reading comprehension and may make translations useless. This is especially critical for user-generated content such as social media posts -- which are often short and contain non-standard language -- but applies to a wide range of text types. The novel and ambitious idea in this proposal is to devise methods and algorithms to exploit global multi-modal information for context modelling in SMT. This will require a significantly disruptive approach with new ways to acquire multilingual multi-modal representations, and new machine learning and inference algorithms that can process rich context models. The focus will be on three context types: global textual content from the document and related texts, visual cues from images and metadata including topic, date, author, source. As test beds, two challenging user-generated datasets will be used: Twitter posts and product reviews.This highly interdisciplinary research proposal draws expertise fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural studies of Na,K-ATPase isoforms and mutants' (NaKStruc) targeting Horizon 2020.

assistant: **Abstract**

Isoform complexes of Na,K-ATPase , an αβ-heterooligomer, have recently been identified as crucial regulators of muscle and neural physiology and were furthermore identified as the primary cause of neurological diseases. Of particular interest are α2β2 & α2β3, which are expressed in muscle and astrocytes (α2β2) and the ciliary body (α2β3). Both exhibit a significantly lower affinity for K-ions and a steeper voltage dependence than the housekeeping α1β1 complex. These features keep α2-isoforms inactive at resting conditions but allow to respond to transient elevations of extracellular K after muscle and neuronal activity. Moreover, both complexes can be selectively inhibited by cardiac steroids, making them promising drug targets for the treatment of heart failure (α2β2) and glaucoma (α2β3). Differences in affinity for K and cardiac steroids were attributed to the β-subunit recently, yet the root cause and molecular details remained elusive. Hence, I propose to investigate the structure of α2-isoforms purified from the yeast Pichia pastoris by x-ray crystallography and cryo electron microscopy. In addition to its physiological and pharmacological role mutations of Na,K-ATPase cause severe neurological diseases, e.g. Alternating Hemiplegia of Childhhod. Disease mutations typically inactivate the Na-pump causing severe motor and cognitive disorder. However, the effects of mutations on the ATPase’s reaction cycle have not been investigated in detail, leaving the cause of inactivation in the dark. Part two of the proposal addresses this gap of knowledge. The two most common mutations E815K and D801N will be expressed in P. pastoris and the effect of mutations on partial reactions of the Na,K-ATPase’s reaction cycle will be investigated and subsequently, structural studies wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Tunisian EURAXESS Network'.

assistant: **Concept**

Tunisian EURAXESS Network or the TEN project is the initiative led by the Ministry of Higher Education and Scientific Research to boost and encourage the mobility between Tunisia and the European Research Area (ERA).The objectives consist of enhancing the researchers mobilities between both zones. The EURAXESS portal, including the Tunisian national portal which will be developed during the project, will be the concentration point of all the news and useful information about the researcher's mobility and career support that may be needed. More specifically;-The outgoing researchers will be provided with all the information necessary in order to facilitate their mobility and their integration.-The incoming researchers will also find information to help in their integration and will be supported by the EURAXESS Service Centres and EURAXESS Contact Points that will offer help and services all along with their stay in Tunisia.-The non-mobile researchers will be able to find career development resources and will be able to exploit the partnering possibilities that the portal offers.Thanks to the implementation of the project throughout three years in the shape of 5 work packages, all of the actors mentioned above will benefit from the TEN experience. They will be supported and accompanied by specialized skilled staff (WP3, WP4) in order to enhance their experience. They will also be constantly contacted during their mobilities to receive their feedback and provide a follow-up.The mobile and non-mobile researchers may benefit from the TEN portal where they can have access to different types of information (WP2). This information will also be available through dissemination and communication (WP5).These collaborations and projects are encouraged with the goal of reinforcing re