RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Computational Lithography for Directed Self-Assembly: Materials, Models and Processes' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Directed self-assembly (DSA) of block copolymers is one of the most promising techniques to enable the continued miniaturization of ICs and to boost the performance in More Moore. It combines top-down photolithography for creation of guiding patterns with engineered new materials and processes to facilitate cost effective bottom-up techniques for pattern density multiplication and defect rectification. An industry scale application of DSA still faces two challenges: i) The host substrate heavily impacts DSA. The resulting pattern formation must be well understood and modeled in order to optimize its efficiency and avoid defects. ii) The specific properties of DSA must be considered early in the design process.CoLiSA.MMP will develop new material and process models and a computational lithography framework for DSA. Existing and new, specially designed atomistic and coarse-grained models will be combined with experimental data to develop and calibrate efficient predictive reduced models, seamlessly integrated in lithographic process simulation. The new modeling capabilities will be used to establish new design flows which include the lithographic generation of guiding patterns and the resulting patterns after DSA. Inversion of the problem will predict lithographically manufacturable guiding patterns and process conditions for given target structures. The extended capabilities of computational lithography will be also used to improve materials and processes which are still under development, to study the root causes of DSA specific defects and to propose strategies to avoid or reduce them.CoLiSA.MMP combines European expertise in soft matter physics, block copolymer chemistry, lithographic process and computational lithography. This will help to bridge the gap between the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'REsistive-Switch CompUting bEyond CMOS', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Digital computers rely today on CMOS (complementary metal-oxide-semiconductor) technology, which improves its performance every generation thanks to the Moore’s law of downscaling. As CMOS transistor size approaches few nm, alternative logic switches with better scaling capability must be identified to prolong Moore’s law beyond CMOS. Among the emerging switching concepts, resistive switching (RS) devices can change their resistance by electrically-induced redox reactions. RS provides the basis for the resistive memory (ReRAM) technology which is currently investigated as future computer memory and storage technology. The objective of this project is to design, develop and demonstrate a novel computing paradigm based on RS devices. The project will pursue this objective at 3 levels of increasing complexity, namely the device fabrication, the design of new logic gates and the demonstration of computing circuits. RS logic will be finally compared to CMOS and other approaches to identify the strength and the potential applications of RS logic in the computing scenario.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Centre de recherches du cyclotron'.

assistant: **Innovation**

Description:The Cyclotron Research Centre (CRC) of the Catholic University of Louvain at Louvain-la-Neuve operates three different cyclotrons for use by national and foreign experimental groups. Its unique character, in Europe and in the world, resides in the acceleration of very intense and pure radioactive beams in the low-energy region (0.2 to 10MeV per nucleon). These beams are most suitable for direct nuclear reaction cross-section measurements in the field of Nuclear Astrophysics and for Nuclear Physics experiments in the vicinity of the Coulomb barrier. Beams of 6He, 11C, 13N, 18F, 18Ne, 19Ne, 35Ar are routinely available and new beams of 7Be, 14O, and 15O are under development. Other beams available include light and heavy ions (from gaseous and solid elements), monokinetic fast neutron beams in the 20 to 80MeV range and very intense neutron beams for radiobiology and component testing. Experimental facilities include among others, a large reaction chamber, solid state detector arrays, a 4p neutron detector DEMON, the isotope separator on-line LISOL, and the Heavy ion Irradiation Facility (HIF) for SEE studies.Application:Experiment proposals should be submitted to the Cyclotron coordinator, Dr. Carmen Angulo (e-mail: angulo@cyc.ucl.ac.be).Each proposal should cover the following topics:i) general context and motivation;ii) description of the experiment;iii) equipment;iv) timing and beam time required;v) possible by-products of interest.A completed beam time request form should accompany it. These forms can be obtained from the web site of the laboratory (http://www.cyc.ucl.ac.be). To get access, the Program Advisory Committee (PAC) should approve the proposal. The PAC meets twice a year (beginning of January and middle of June). Proposals must be sent about one
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metapopulation models of the intra-host dynamics of persistent infectious pathogens and the immune response.' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This interdisciplinary research aims to combine pathogen and immune dynamics with met population theory. It will form an important link between the research on spatial population dynamics and the intra-host dynamics of infectious diseases such as human immunodeficiency virus (HIV); polyomavirus type BK (BKV), hepatitis B (HBV) and hepatitis C (HCV). The goal of this research project is to address the following questions:(A) Can different immune mechanisms contribute to level-level persistence of a viral disease by changing complex local dynamics and thereby decreasing synchrony in the dynamics of different local virus populations?(B) Does subdivision of a large population of viruses into a large number of small subpopulations by different immune mechanisms increase or decrease eradication time in vivo?(C) What are the implications for the evolution of immunology memory (B-cells and T-cells)? (D) How do qualitatively different sub-compartments of infected cells contribute to long-term stability and persistence of a viral infection? A natural conceptual framework to answer the above questions comes from ecology, where it is known as \level dynamics\". The proposed research project has the potential to lead to important insights in the pathogenesis of HIV and the design of therapeutics and vaccines. It further may help to preserve the function of transplanted organs in kidney recipients suffering from BKV infection, which not only increases the quality y of life of those patients, but also reduces the demand of donor organs. The research project is interjectorily and has the potential to lead an exchange of knowledge between ecology and the life sciences. With respect to the transfer of knowledge within the European Community the project will allow me to learn how to apply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative Product for train door condition monitoring based on vibration analysis algorithms' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

It is crucial to reduce rail operational costs as well as increasing the reliability of service especially in terms of punctuality. Train doors prove to be a critical element with respect to both maintenance cost and cause of train delays. Door actuator defects are the most common found; especially in older trains where door malfunctions amount to 25%-50% of the rolling stock defects. To overcome this, a consortium led by German SME Hitex, have come together with the aim to rapidly seize the business opportunity presented by commercializing the VA-RCM system.VA-RCM is a highly innovative condition monitoring system based on cutting-edge technology involving advanced vibration analysis techniques. Its unique features will enable accurate assessment of train door actuators as well as targeted feedback on subsystem malfunctions well in advance of their potential occurrence.Train operators and passenger train car manufacturers will benefit from the VA-RCM system by improving the efficiency of train doors and reducing the failure rate or downtime of trains, thus reducing maintenance cost.The consortiums vision is to achieve gross sales of 140 million by 2025; a ROI of 60.68 within the first 4 years of commercialisation; and business growth which will create 1298 new jobs. It is our strong belief that the Fast Track to Innovation Pilot is the ideal financial instrument for us to accelerate the commercialization of VA-RCM.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Myelin at the crossroads of Development and Disease' (Myel-IN-Crisis) under Horizon 2020.

assistant: **Objectives**

The oligodendrocyte, the largest cell in mammalian biology, greatly enables central nervous system (CNS) function through production of a single substance: myelin. Oligodendrocytes undergo a dramatic 1-2 day metamorphosis during myelination, increasing their cell surface area ~6500-fold with proteolipid extensions to nerve axons in the CNS white matter.  How is this synthetic feat accomplished? We lack a comprehensive understanding of machinery that precisely coordinates transcription, translation, lipid synthesis and energy production. Moreover, how do these mechanisms become so intensively upregulated during myelination? Does this extraordinary transient state put the myelinating oligodendrocyte at risk of death in diseases of white matter? These questions underlie the Aims of the proposal “Myel-IN-crisis.”  I propose (Aim 1) testing whether an “Integrated Synthetic Programme (ISP)” controls oligodendrocyte differentiation, metabolic and synthetic requirements of developmental myelination. In Aim 2, I will investigate roles for “smart sensor” oxygen (HIF) and nutrient (mTOR) pathways in regulating initiation and termination of the ISP. During development, extrinsic white matter injury in preterm infants leads to cerebral palsy, while intrinsic defects in myelin protein PLP1 cause the fatal human leukodystrophy, Pelizaeus-Merzbacher disease (PMD). Preliminary studies indicate transcriptional and translational dysregulation in human PLP1-mutant oligodendrocytes, which become iron overloaded leading to apoptotic cell death. In Aim 3, I propose that either extrinsic (e.g., hypoxia) or intrinsic (e.g., PLP1 mutation) factors promote a “Universal Stress Response (USR)” in the pre-myelinating oligodendrocyte that leads to toxic dysregulation of the ISP.  Finally, in Aim 4 we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Desing of novel in2o3- and sno2-based sensors for carbon monoxide combustion emission monitoring using innovating sensor technologies and methods of theoretical modeling' (UNDERSTANDING) under Fifth Framework.

assistant: **Objectives**

Design of novel low cost SnO2- and ln2O3-based sensors for monitoring of CO in combustion emissions is the purpose of this project. The main specific objectives are: -experimental and theoretical investigations of Sn02 and In203 surface parameters, important for high effective sensor creation: -design of innovating sensor technologies, to improve the operating characteristics of CO gas sensors (GS) and reduce their costs. Theoretical model of metal oxides (Sn02 and In203) real surfaces phenomenological model of GS will be developed. The engineering solutions and modes of a deposition permitting to form nano-crystallites (8-25 nm) of gas sensitive Sn02- and In203-based thin (10-200 nm) films with controlled structure and chemical composition will be found using spray pyrolysis technology. A novel designs of the gas sensors able to monitor in site combustion products with temperature of detected gas 300 C and reduced concentration of the oxygen (5-10%) will be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mode of action of Bacillus thuringiensis VIP proteins in Helicoverpa armigera and Spodoptera exigua' (VIPHASE), addressing dissemination and exploitation.

assistant: **Impact**

VIP (Vegetative Insecticidal Protein) proteins are a recently discovered family of Bacillus thuringiensis (Bt) insecticidal proteins, which are secreted by the bacteria during the vegetative growth, with no structural relationship to the best known family of Bt toxins, the Cry proteins, although it has been shown that, similarly to them, the target of VIP proteins is the insect midgut. Despite the interest in this new family of insecticidal proteins, there is very little information on their mode of action and especially on the events that take place once the VIP proteins are ingested. In order to use in the near future VIP proteins as part of the relatively scarce arsenal of environmentally-friendly insecticidal products, a deeper understanding of their mode of action is pivotal. The proposed project aims to study in detail the mode of action of different Vip3 toxins, active against larvae of two lepidopteran species, Helicoverpa armigera and Spodoptera exigua, which are world-wide pests. H. armigera is relatively tolerant to Vip3 proteins while S. exigua is very sensitive.  The first part of the working program will consist on searching for differences in the activation of the Vip3 proteins by midgut juice from the two species. The activity of the resulting products will be tested in bioassays with larvae from the two species. In a second phase of the project we will determine the binding properties of labelled activated Vip3 proteins with brush border membrane vesicles (BBMV) prepared from larval midguts. In a third phase, the permeabilisation capacity of different Vip3 proteins on BBMV will be studied by means of a spectrofluorimetric technique using a membrane-voltage-sensitive dye. Finally, primary cultures of isolated midgut cells will be established and tested f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Guard-driven immunity against pathogens'.

assistant: **Concept**

Successful pathogens use virulence factors to inhibit immune defenses. To counteract this, host guard proteins monitor the integrity of pathways (guardees) that are attacked by virulence factors, such that inhibition of the guardee activates guard-driven immunity. Instead of directly detecting microbial components like canonical innate immune (pattern recognition) receptors, guards are activated by sensing the activity of virulent microbes. While guard-immunity is common in plants, only a few mammalian guard-pathways are known and mammals are thought to heavily rely on pattern recognition to detect pathogens. We have recently described the MORC3-MRE pathway, the first mammalian guard-sensing pathway that recognizes the virulence- associated activity of viruses to induce a protective interferon (IFN) response. I hypothesize that mammalian guard-sensors are highly relevant for both immune homeostasis and immunity and propose to test this hypothesis by focusing on the MORC3-MRE pathway. Utilizing genetic approaches in human monocytes and mice, we will reveal novel components and molecular mechanisms of the MORC3-MRE pathway and investigate its role in homeostasis and immunity in vivo. The main hypothesis of this proposal is that guard- sensing allows mammalian immune cells to broadly recognize the activities of virulence factors. We aim to conduct forward genetic screens in human monocytes to identify virulence-associated activities of pathogens that are sensed by the immune system. Functional genomics and biochemical approaches will identify the attacked guardee, the guard-sensor and molecular mechanism of guard-sensing. In summary, we will experimentally test the novel concept of guard-immunity in mammalian immune defenses. These experiments will generate fundamentally n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Feasibility study of internationalisation of dust control products using innovative cleantech technology'.

assistant: **Concept**

JMV Urakointi Ltd (JMV), specialising in deconstruction and renovation jobs, has been developing novel dust control products to improve deconstruction and renovation process. According to preliminary studies by patent office, there are no similar products and methods on the EU market. The aim is to be the first company on the EU market providing reusable and affordable dust protection solution, which meet the legislative requirements also in the future. For the purpose of internationalisation of the dust control products, the principal owner of JMV and three other key persons established Dust Shelter Finland Ltd (DSF) in August 2013. The existing dust protection markets in the EU are estimated at 4% of the renovation, i.e. approx. EUR 24 billion per year, which can be expected to increase as the regulations tighten. DSF's turnover target for 2020 is EUR 120 million, representing approx.1% of the European market for dust protection. Today, the dust protection methods used at the construction sites are designed for a single use and they are built at the location. This takes a lot of time and materials, and when dust protections are dismantled after use, they generate waste. In addition, they will not meet tightening requirements in the future. The competitive advantages of the novel dust control products are, among other things that they meet the EU legislation and are reusable offering energy and material efficiency both to construction and deconstruction. In addition, they are easy to dismantle and reinstall, hence the construction work will also proceed faster. Using past customer feedback JMV has identified the key problems in the current dust protection process. The objective of this feasibility study is to systematically survey, by means of the market studies and cu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Researchers Night in Sweden: ForskarFredag' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Researchers' night in Sweden, ForskarFredag, FF (Research Friday in English) is a chain of nine Activities spread geographically over Sweden that will be organised on Friday 22 September 2006. FF, which aims at bringing the broad public face to face with researchers, is coordinated by Public & Science (Vetenskap & Allmanhet, VA). Partners of the project are several universities, a science discovery centre, a regional council, a competence development agency, an industrial innovation foundation and the Swedish Research Council. Each partner is responsible for a FF Activity that is part of the European Researchers' night initiative. The project is facilitated by the partners' extensive and varied links in industry and academia. The objective of the innovative and original actions at each FF Activity is to allow for direct involvement of the public together with researchers by hands-on visualisation of research in an informal and festive environment.Aiming at fun, relaxed actions will help attract the broad public, especially those who are not normally interested in research. The impact on the public at large is significant since Activities are carried out at nine different venues. Estimated visitors in total are 8 000. Those not able to attend the venues are invited to engage in discussions with researchers through an interactive web-activity. Local schemes vary, but the Activities will have a common message: research is fun and exciting and it influences everyone's day-to-day life. To ensure maximum visibility an awareness strategy, showing that local Activities all are parts of the European initiative Researchers' night, will be implemented at an early stage. Unanimous objectives, similarity of contents as well as a website providing all the necessary information and an