RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers'.

assistant: **Innovation**

Nucleosomes, ~147 base pairs of DNA wrapped around an histone protein octamer, package and protect nuclear DNA but also carry important biological information. The position and composition of nucleosomes along chromosomal DNA is a key element of defining the state and identity of a cell. Chromatin remodellers are ATP dependent molecular machines that position, move or edit nucleosomes in a genome wide manner. Collectively, they shape the nucleosome landscape and play central roles in the maintenance and differentiation of cells, but also in pathological transformations. INO80, a megadalton large remodeller consisting of 15 or more subunits, is involved in replication, gene expression and DNA repair. It models chromatin by positioning barrier nucleosomes around nucleosome free regions, editing nucleosomes and generating nucleosome arrays. However, structural mechanisms for INO80 and other remodelling machines are poorly understood due to their complexity. To provide a comprehensive mechanistic framework, to understand how INO80 senses nucleosome free regions to position barrier nucleosomes and how it generates arrays or senses DNA breaks, I propose a challenging but ground-breaking endeavour using a combination of cryo-EM and functional approaches. We address structures of fungal and human INO80 complexes at promoter regions, on di-nucleosomes and at DNA ends and develop quantitative positioning assays to reveal common and distinct features of shaping chromatin in different species. We also explore cryo-EM as tool towards revealing distinct steps the chemo-mechanical remodelling reactions. The proposed research will help derive fundamental molecular principles underlying the modelling of the nucleosome landscape.


**Keywords:** Chromatin remodelling, nucleosomes, INO80,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MDO and REgulations for Low-boom and Environmentally Sustainable Supersonic aviation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

MORE&LESS addresses the challenge of contributing to help Europe shape, together with the international community, high environmental standards in line with ICAO Assembly Resolution A39-1, by a thorough and holistic analysis of the environmental impact of supersonic aviation. MORE&LESS aims at maintaining a high level of citizens' and environmental protection at local, regional and global levels, and supports the consequent establishment of regulations and procedures for the future supersonic aviation through solid technical bases. The scientific findings in the fields of aerodynamics, jet-noise, sonic-boom, propulsion, pollutant emissions and environmental impact are in fact transposed into guidelines for the Regulatory Community. Through low and high-fidelity modelling activities and test campaigns, already accepted and validated software tools are enhanced and extended to cover supersonic aviation, to be eventually integrated into the multidisciplinary holistic framework. The application of this framework to the case-studies is the proving ground to verify that the enabling technologies of supersonic aircraft, trajectories and operations comply with the environmental requirements. The case-studies cover the entire spectrum of supersonic speed regime and include the most promising aircraft configurations, propulsive technologies and alternative fuels, such as bio-fuels and liquid hydrogen. MORE&LESS fosters international cooperation, thus paving the way towards the definition of global and internationally agreed regulations, while contributing to maintain world-class knowledge and skills in Europe in the field of supersonic aviation. MORE&LESS targets the engagement of new generations of students, scientists and engineers to inspire and challenge them to build and man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Photovoltaic module life time forecast and evaluation' (SOLAR-TRAIN).

assistant: **Concept**

The quality assurance in the photovoltaic industry is yet in its infancy, requiring both underpinning science and trained personnel to reduce costs of energy. An unmet industrial requirement is an accelerated, and operating environment specific, service life time and energy yield assessment. SOLAR-TRAIN will qualify ESRs in the field of PV durability as part of a highly innovative, multi-disciplinary project meeting industry requirements. The objective is to develop novel, validated models for the service life time and energy prediction of PV modules and systems. The elements to this puzzle are researched in the frame of 14 PhD projects with individual areas of focus, such as (a) climatic degradation factors, (b) system analytics, (c) material (polymer) parameters, (d) service life & energy models, (e) linking production to performance and (f) performance enhancement by improved O&M. Commercial and test samples will be produced and tested in the distributed measurement campaign during this project. They will be exposed to state-of-the-art and to-be-developed stress cycles to allow a validated link of degradation to stresses, production methods, materials and methods of deployment. Accelerated and lower cost test cycles for the assessment of innovative materials and module developments will be delivered. The project is integrated both in terms of research as well as training. This inter-sectoral approach provides excellent theoretical and technical background as well as immersion in different business sectors and career mentoring, allowing ESRs to build up a sustainable professional network across Europe. For a most effective cross-sectoral training, the project’s beneficiaries and partners represent the entire value chain, from materials developers / manufacturers throu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Organisation and Delivery of the Luxembourgish Presidency Conference on the European Strategic Energy Technology Plan (SET-Plan)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The European Strategic Energy Technology plan (SET Plan) aims at creating a new European policy for Energy technology, by delivering a joint strategic planning, effective implementation, optimised resources and a new approach to cooperation. This includes a complex coordination of member states, PPPs and research networks.Therefore, “checking points” are necessary to assess the activities developed so far, review the action plan and put together key players from the industry, research entities, SMEs, public authorities, associations, etc. in a collaborative effort.To this aim, every year a major conference is organised in a member state to network, review the achievements, discuss strategies and define a new action plan that helps achieve the ambitious targets in energy technologies.In order to organise the 8th SET Plan Conference, the Luxembourg presidence, as major authority of the selected venue, has chosen MYENERGY GIE, a Luxembourgish Energy agency with expertise in events based on promoting energy efficiency and the use of renewable energy sources.MYENERGY GIE will make sure that relevant debates are facilitated (i.e. R&I to achieve key energy policy targets, Energy Union concept) while presenting the SET action plan to all the stakeholders. To this aim, management, dissemination and communication strategies will be produced and deployed in order to create maximum awareness of such an event at the regional, National an EU level.


**Keywords:** SET Plan, Conference organisation, energy efficiency, energy management, low-carbon technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Forest resources for Iberian Empires: Ecology and Globalization in the Age of Discovery' (FORSEADISCOVERY).

assistant: **Innovation**

In the Early Modern Age (16th-17th centuries) the construction of ocean-going ships was paramount to the development of cultural encounters in what became the Age of Discovery and European expansion.  In the case of the Iberian Empires, the establishment of new trade routes brought up the need for armed merchantmen, galleons and smaller vessels, placing unprecedented demands on Iberian forests for the supply of construction timber. Forestry and sea power became inextricably linked, creating new geopolitical tensions, alliances and forest regulations. Key questions in this context are: could Iberian forest resources sustain the increasing demand of sound timber, or was the wood imported from elsewhere? If so, how were the trade networks organized? And did the lack of raw material force the technological changes occurred in shipbuilding in the 16th century, or were they a result of exchange between Mediterranean and Atlantic shipbuilding traditions? This project will address these questions through a multidisciplinary and innovative training research program to improve the understanding of our historical past, our cultural heritage, and our knowledge of the use of resources for shipbuilding. The prerequisite for such approach is combining knowledge derived from Humanities and Life Sciences. The aims of the project are: i) to consolidate a research line combining historical research, underwater archaeology, GIS and wood provenancing methods (dendrochronology, wood anatomy and geo/dendrochemistry);  ii) to increase the background and experience of trainees in the different research areas, by engaging the fellows in training courses and workshops aimed at developing their scientific, communication, and management skills; and iii) to develop their transferable skills for futu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mapping the Connectome Dynamics of Trauma Psychopathology' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Exposure to a traumatic event can induce psycho-physiological reactions and symptoms that in most people recede over time. A minority of trauma-exposed individuals develop posttraumatic stress disorder (PTSD), characterized by severe functional and emotional impairment. The global burden of PTSD is estimated in the hundreds of billions of Euros and millions of years lived with disability. Individual differences in neurobiological vulnerability to traumatic stress have been studied extensively, yet the impact of neuroscience on clinical application is minimal. The proposed work aims to address this gap using three work packages (WPs). WP1 will establish a detailed open-access database to study the impact of traumatic stress on brain structure/function connectome: 1000 participants with PTSD, 1000 trauma-exposed healthy, 1000 non-exposed. WP2 is a longitudinal study of the effects of trauma exposure. It will delineate long-term trajectories of stress-related symptoms and corresponding connectome dynamics. Building on already collected data from 579 veterans who were followed over four years, starting with a pre-exposure baseline, we will add two new data points, at 7- and 9-year post-exposure, to reveal long-term adaptation patterns. WP3 is a 3-armed randomized controlled trial to test the impact of MRI-guided neurostimulation of cortico-hippocampal networks on brain connectivity patterns and severity of memory symptoms. We target cortico-hippocampal connections with broad impact on cortical circuitry, consistent with our focus on whole-brain connectome correlates. Moving beyond separate analyses of brain structure and function in relation to a heterogeneous definition of PTSD, we will use combined structure/function modeling in relation to specific symptoms. Together the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Up-scaling, demonstration and first market application of Hydrokemos’ patented technology as the most eco-efficient and cost-effective solution for nitrate polluted water treatment'.

assistant: **Concept**

Hydrokemos, a high tech Spanish SME, aims to demonstrate and commercialise the first fully clean equipment to purify nitrate polluted water.In the EU +20% of groundwater is contaminated by nitrates due to the use of fertilizers that have been and still are extensively applied in agriculture. On the other hand, demand for freshwater is increasing by 64 billion cubic meters every year. Groundwater is essential for meeting this increasing demand and existing solutions to purify it are highly inefficient and/or produce dangerous residues.Electrodenitrification (technology developed and patented by Hydrokemos) is the first fully clean technology that destroys nitrates dissolved in water transforming them into air (no waste is produced) and generates energy that is re-inserted into the system making it extremely energy-efficient.The objective of this project is to demonstrate – at full scale and in real market applications – the technical and commercial excellence of Hydrokemos’ unique technology. During the project, Hydrokemos will up-scale the existing prototypes building 4 full-scale prototypes to demonstrate its economic and technological performance across a range of typical industrial applications. These applications are:- Freshwater supply to food or metal industries;- Water purification for re-injection to public network;- Remediation of high nitrate waste-waters (metal industry and similar);- Prevent eutrophication;Hydrokemos will then operate these full-scale prototypes in real operational conditions demonstrating that electrodenitrification achieves much better performance than any other available solution (at least -50% reduction in investment and +20% in performance). Finally, business success means €38m incomes in year 5 with IRR 93% and NPV 7.523.711 € for Hydr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Rise of scientific excellence and collaboration for implementing personalised medicine in Estonia' in the context of a Horizon 2020 call.

assistant: **Objectives**

Emerging personalised medicine initiatives have the perspective to cut healthcare costs and improve the overall health of the population. Taking into account the individual’s molecular characteristics complemented by environmental and lifestyle factors, will allow to develop more precise and improved disease prevention and treatment programs compared to conventional methods.  As an example of potential for personalised medicine, an estimated 90% of drugs are effective in only 30-50% of the population, which means that more than a third of all money spent on drugs has been ineffective. Research opportunities provided by the unique sources of EGC-UT Biobank, nation-wide Electronic Medical Records systems and the Estonian National Personal Medicine Pilot project can be effectively translated into improved understanding of disease etiopathologies and clinical benefit through early diagnosis, risk stratification, treatment and management. The ePerMed project is aimed at increasing the scientific excellence of EGC-UT in the fields of functional and statistical genomics of common and rare diseases by capitalizing on knowledge transfer from two internationally renowned partners in the field of human and medical genomics – UNIL-CIG in Switzerland and UH-FIMM in Finland.As a foreseen result of the ePerMed project, EGC-UT will have the capacity to move from the current research on the genome-wide association studies to advanced research of disease mechanisms and to clinical benefits through early diagnosis, reliable risk stratification and improved treatment strategies. Ultimately, this will enable EGC-UT to deliver effective personalised medicine across several clinically relevant phenotypic traits and diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Direct Experimental probe of the Lorenz invariance violation in the Top-quark physics at the ATLAS experiment.'.

assistant: **Concept**

The Standard Model (SM) is a theory which accurately describes the elementary constituents of matter and interactions between them at the energy scales we have been able to probe in experiments up to the present day. However, since in the Nature we observe physics phenomena beyond the SM, it is expected that the SM is a low-energy effective approximation of a theory that describes the physics of particles and their interactions in a broader way. Lorentz Invariance is a fundamental symmetry of the SM, but it is not expected to be conserved necessarily at the high energy scale of quantum gravity where space-time could undergo violent fluctuations. The violation of the Lorenz invariance (LIV), which is predicted by some extensions of the SM theory, would manifests itself at energies accessible by the experiments nowadays.I propose to preform the first search for the possible LIV in the top quark interactions at the ATLAS experiment at CERN’s Large Hadron Collider (LHC) that will pioneer the use of innovative approaches to analyse collision data taking into account detector orientation in the space-time continuum. The project will comprise phenomenological study to identify observables most sensitive to LIV, development of the novel framework for analysing data as a function of the sidereal time, study of the time-dependence of the ATLAS detector performance and state-of-the-art collision data analysis. My long-standing experience with measurements targeting the final states with top quarks and Higgs boson decays, provide me with unique expertise to perform this search and unlock the hidden potential of the LHC collision data. In addition, I plan to use my expertise in the jet flavour tagging and further improve the performance of the b-jet tagging algorithms for the upcomi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Affordable zero energy buildings' (A-ZEB) under Horizon 2020.

assistant: **Objectives**

Project Proposal: Affordable Zero Energy Buildings (A-ZEB) This project aims to achieve significant construction and lifecycle cost reductions of new NZEB’s through integral process optimization in all construction phases. The main objectives are:a) To develop a methodology for cost reduction in synergy with better energy/ grid-interaction/comfort/environmental performances of new NZEB’s for the European climate zones with a framework of tested strategies and technologies from which designers, builders and urban planners may combine the best for their context. b) To disseminate the gained and consolidated knowledge and experience as market-ready solutions to the widest possible EU audience and this way inspire stakeholders to take up new NZEB’s with RES concepts and implement the cost-effective solutions.c) To facilitate frontrunners and innovators, from policy-makers to progressive contractors, to help transform the building sector into a sustainable industry, with ready-to-use material and strategies to influence their target groups.Optimizing construction processes to fully integrate available solutions (in the areas of process, technology, contracting) is seen as the largest potential in lifecycle cost reduction and is at the core of the project. A-ZEB proposes to create a common methodology on this. The main steps are: - Evaluate available experience and solutions- Create a common methodology for cost reduction - Apply the methodology to demonstration projects- Finalise the methodology including lessons learned - Disseminate the results The project will pave the way for the process and organizational innovation in construction, to enable significant cost-reduction and solid market acceptance of NZEB’s.