RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'M80 - an hybrid-electric regional commercial aviation Aircraft' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Sustainable aviation is important for the EU. Denmark and Sweden have set a target to achieve 100% fossil-free domestic flights by 2030. Given that developing a new aircraft typically takes 8-10 years, it is imperative to commence work immediately if the EU intends to meet its environmental and sustainability objectives, including zero-emission aviation. Funded by the European Investment Council, the Maeve M80 project is dedicated to the creation and commercialization of the world’s first hybrid-electric aircraft for the commercial aviation market, capable of decarbonizing existing flight routes in the regional aviation segment. It’s Maeve’s mission to reduce more than 50 MT of CO2 from commercial routes before 2040. M80 can accommodate 80 passengers and cover distances of up to 1.482 km, and is aimed for entry-into-service in 2031.


**Keywords:** ELICA,Commuter aircraft,Electric aircraft,Green aviation,Passenger aircraft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Best Practices for IPR and Technology Transfer in Nanotechnology Developments' (NANO2MARKET).

assistant: **Concept**

The lack of models for technology transfer at nanotechnology developments is of increasing concern for the sector. This CSA will fulfil this gap providing guidelines for technology transfer and rules for IPR and license agreements in nanotechnology developments. To achieve these objectives, a consortium is formed by: 1) Key European research centres in different areas of nano and converging technologies, 2) Outstanding agencies for IPR advice, 3) Market analyst experts,industry associations and venture capitals, as end clients of IP. Constructing value chains of the transfer of each technology the consortium will analyse specific applications of the different areas of the nanotechnology R&D European strategy: medical applications, information technologies, energy, materials, manufacturing, instrumentation, food, environment and security. Our objective is to classify the technology application areas of nanotechnology into different clusters according to: development costs, market time, complexity of licensing, etc. In parallel, a mapping of the technology and actual and forthcoming market will be analysed according to: competitiveness, geographical area, development potential, risks etc. Specific data mining tools will help to conclude the key worldwide actors of development and commercialisation of the different technologies. Also, actual IPR cultures and technology transfer rules will be listed according to the features of their market and technology. Matching these IPR technology transfer models with the concluded value chains and market and technology mapping, will allow concluding business models and setting efficient rules for technology transfer. All models will be discussed at consortium seminars, where general algorithms are expected to be excerpted. Specific gu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Single-Cell Epigenetics in Cell Fate Determination' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The demonstration of induced pluripotency and direct lineage conversion of cells has led to remarkable insights regarding the roles of epigenetic modifications in mediating cell state transitions. However, approaches to elucidate the molecular mechanisms behind induced reprogramming are hindered by the inefficiency of induction and the interplay of reprogramming mechanisms with other cellular processes such as the cell cycle, which leads to variability in induced cell populations and limits the conclusiveness of bulk analyses. Here I propose to develop mass cytometry-based methods to monitor mRNA levels and gene locus-specific epigenetic modifications in single-cells. Thereby, the multi-dimensionality of mass cytometry will enable simultaneous measurements of up to 40 additional single-cell parameters, such as surface markers and intracellular phosphorylation sites. This platform will be used to profile cell populations at specific time-points during reprogramming of human somatic cells into induced pluripotent stem cells. The obtained data will be organized into clusters of similar cell phenotypes resulting in continuous single-cell maps that chart epigenetic changes and accompanying marker expressions during induced reprogramming. These maps will then serve as references to monitor the effects of chromatin-modifying small molecules that affect the efficiency of reprogramming. In combination, these analyses will lead to a more detailed understanding of the hierarchical and dynamic organization of reprogramming and will ideally define gene locus-specific epigenetic events that are rate-limiting for the process. This fine-grained view of reprogramming will then be used to define minimal combinations of early cellular markers that are likely to predict cell fate. In the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Predicting rewilding impacts on ecosystems through ecological interaction networks' in the context of a Horizon Europe call.

assistant: **Objectives**

Scaling up ecosystem restoration is critical during the UN Decade of Ecosystem Restoration (2021-2030) to combat the climate crisis, enhance biodiversity and restore essential ecosystem services. Trophic rewilding, which often involves the reintroduction of species to reinstate natural processes, is promising but remains controversial due to uncertainties about its broader, long-term impacts on ecosystems. To address these concerns, further research is needed to guide effective, science-based restoration efforts.In this context, NetRewild addresses key challenges in restoration ecology by focusing on the complexity of species interaction networks that drive ecosystem processes. Interaction networks serve as a key link between individual species and overall ecosystem properties such as structure, stability, and function. This innovative approach moves beyond traditional restoration methods, which typically emphasize individual species or habitats, offering a more holistic perspective on ecosystem dynamics. NetRewild will use trait-based models to predict animal-plant interactions and associated ecological functions, such as seed dispersal and plant regeneration, based on species traits and assemblages across Natura 2000 sites. The research will focus on two main areas: first, how functional traits explain the mechanisms driving interaction patterns and ecological processes, addressing a critical knowledge gap essential for predicting future ecosystem impacts; second, how historical changes in herbivore communities and future rewilding scenarios shape ecosystem function and stability. The expected results will provide a science-based foundation for actionable strategies to support successful rewilding initiatives, while integrating insights from real-world applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Synthesizing Meiotic Crossover Hotspots in Arabidopsis'.

assistant: **Concept**

The majority of eukaryotes reproduce sexually via meiosis. During meiosis homologous chromosomes pair and undergo reciprocal genetic exchange termed crossover. Meiotic recombination is a major evolutionary force and has a profound effect on patterns of genetic diversity in sexual species. Crossovers distributions are highly non-random and are typically focused in narrow hotspots. Study of hotspots throughout eukaryotes has revealed combinations of genetic and epigenetic factors that contribute to their distributions. In this proposal we will use the extensive genetics and genomics tools available in Arabidopsis to comprehensively dissect hotspot patterning. The strategic aim of the proposal is to use this knowledge to direct de novo hotspots to loci of choice. In the first aim we will use functional genomics to profile the chromosomal distributions of key recombination proteins and test the role of chromatin and higher-order structures in driving these patterns. In the second aim we will study individual hotspots at the fine-scale, to the resolution of individual polymorphisms, using amplification and sequencing of recombinant molecules from gamete DNA. To test genetic versus epigenetic control of hotspots we will use genome-editing to delete hotspot-associated CTT-repeat DNA sequence motifs, in addition to directing DNA methylation in order to epigenetically silence recombination. In the final aim we will use our combined knowledge of hotspot control to implement genome-editing technologies (TALENs & CRISPR-Cas9) during meiosis. This will allow us to rationally control hotspot locations, which will be definitive proof that our models for recombination control are correct. This technology will also accelerate breeding and genome-engineering of our most important crops,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SCAVENGING ON SEPSIS. DEVELOPMENT OF SEPSIS SPECIFIC DRUGS FROM HUMAN SCAVENGER RECEPTORS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Sepsis is a major a life-threatening condition caused by bacterial or fungal infections leading to cardiovascular collapse (septic shock), multi-organ dysfunction syndrome (MODS) and death, and claims more lives that bowel and breast cancer combined. The human Scavenger-receptors are naturally occurring proteins on some blood cells that interact and neutralize core structural components of microbes, providing a novel therapeutic strategy for wide-spectrum sepsis treatment and an alternative to current antibiotic and adjunctive therapeutic approaches of limited success. Sepsia Therapeutics is a R&D start up company developing SIXTIDE, a peptide-drug based on human scavenger lymphocyte receptor CD6, with dual bactericidal and anti-inflammatory action, which protects mice from death in experimental sepsis, in a time- and dose-dependent manner. SIXTIDE mode of action inhibits bacterial growth and blocks the pro-inflammatory properties of bacterial toxins. Sepsia Therapeutics holds IPR on the use of CD6 and CD6 derivatives in the treatment of infection and inflammation disorders and aims for market entry through injectable SIXTIDE.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploring Chemical Reactivity with Organocatalysis' to be submitted under Seventh Framework.

assistant: **Abstract**

The proposed research seeks to redefine the synthetic potential of a fundamental organic transformation: the functionalisation of carbonyl compounds. Today, synthetic chemists can address even the most daunting of challenges connected with the asymmetric catalytic functionalisation of carbonyl compounds at their alpha and beta positions. In contrast, there are no known general strategies for the corresponding direct, catalytic and enantioselective transformation to a carbonyl group at the gamma position.By developing innovative methodologies to effectively address this issue, I will provide a novel reactivity framework for exploring unprecedented transformations. This would strengthen the chemistry toolbox to better face the challenges of modern organic chemistry.I will proceed by combining asymmetric aminocatalysis (a versatile chemical strategy whose potential has not yet been fully explored) with photoredox catalysis driven by visible light. This will provide access to open-shell radical species, which participate in bond constructions that are unavailable using amine organocatalysis alone. Since electron-deficient radicals are known to rapidly react with pi-rich olefins to forge even the most elusive C-C bonds, mild and catalytic approaches to accessing these reaction manifolds offer desirable opportunities for designing new gamma-functionalisations of carbonyl compounds. Developing an innovative system based on a chiral organic catalyst that efficiently harnesses the energy of solar radiation is in line with the European approach to attaining Sustainable Chemistry, one of the central scientific goals of the 21st Century.This proposal challenges the current paradigms for stereoselective functionalisation by providing a template for directly functionalising unmodifie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hydrogel Coatings for Improving the Efficiency of Implanted Electrode Arrays' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Implanted electrode arrays are a key component of neuroprosthetic systems designed to restore functions lost through injury or degeneration of the nervous system. Electrode arrays currently used in clinical practice are made from metals (e.g., Platinum, PtIr alloys) encapsulated in silicone. These materials strike a compromise between electrical properties on one side and good tissue integration on the other. For example, the limited charge injection capacity and high mechanical stiffens of metal electrodes is implicated in challenges with long-term stability, mechanical failure, formation of a glial scar and electrode miniaturization.In the COATARRAY project we will develop a specialized coating designed to radically improve the electrical and mechanical performance of electrode arrays. The coating is based on a bioinspired hydrogel material further endowed with electrical conductivity via incorporation of conductive polymers. The coating can be assembled on a variety of ready-made electrode arrays designed for different applications. In this project we will conduct a thorough electrical characterization of the coating as well as mechanical, insertion, sterilisation, cytocompatibility and accelerated ageing tests. In combination with analysis of the regulatory and commercial landscape, this project will establish an essential milestone towards clinical translation of the COATARRAY technology.If successful, our approach to improving the performance of implanted electrode arrays can lead to better clinical outcomes for established neuroprosthetic systems (cochlear implants, deep brain and spinal cord stimulation) but also to the development of promising new treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Competitive pressure and its social consequences in eu member states and in associated countries' (COMPPRESS).

assistant: **Innovation**

Competition in corporate sector is necessary for efficient resource allocation and economic growth. The project will investigate the evolution of competitive pressure in catching-up and integrating economies, how it affects labour markets, income distribution, social norms and attitudes, how different economic and social policies are responding to its challenges. The project will pursue empirical research on the behaviour of firms, employers, employees and households for some accession countries by also relying on the experience of catching-up EU countries. Our deeper knowledge will facilitate a thorough assessment of policy-making in accession countries and it will draw attention to critical policy issues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Modular cell factories for the production of 100 compounds from the shikimate pathway'.

assistant: **Objectives**

Chemical synthesis is often difficult and may be subject to unclear mechanisms, frequently producing undesired by-products, while the complexity of some compounds may rendered them virtually unattainable. Nature can provide a wealth of products, however typically at very low concentrations, which makes their extraction process expensive. Conversely, microbial production is a well-established process for compounds naturally produced by the hosts or for which there are fully characterised biosynthetic pathways. However, relying on nature’s diversity as a provider for industrial applications typically requires major screenings for pathways, genes and optimisation of cell factories for the efficient production of the target compounds.SHIKIFACTORY100 project aims towards the production of a universe of more than 100 high-added value compounds from the shikimate pathway, a hub in cell metabolism, through the development of an optimised shikimate chassis) and the proposal and implementation of novel biosynthetic routes exploring enzyme promiscuity to propose new pathways for the production of known and newly designed compounds. To champion SHIKIFACTORY100 project a consortium with some of the most relevant players in Europe has been assembled, covering research leading institutions in computational design, rapid prototyping and in vivo implementation of pathways and cell factories. As such, six world-leading research partners, four biotechnology SMEs with complementary focus areas and one large industrial company have been integrated. The research partners will be responsible for novel methods for pathway discovery and compound design, collaborating with the SMEs in the implementation and optimisation of the chassis, while SMEs and industrial partners will lead the assessment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quartzene - Market uptake of the world's first low cost aerogel-type nano-material' (Quartzene) targeting Horizon 2020.

assistant: **Abstract**

Aerogels are nano-materials that are considered the best insulation materials in the world; 10 cm2 of aerogel offer twice the insulation effect, compared to 10 cm2 of a common insulation material such as mineral wool! The problem is that it has not been possible to produce aerogels at a cost low enough for them to be anything other than a niche product, until now. Svenska Aerogel has developed an aerogel-type nano-material “Quartzene®” which can be produced at a 70-90% reduction in cost. This will allow for a market uptake of this aerogel across a number of industry segments, in the EU and globally.Quartzene® can be used as insulation in many applications, from buildings and household appliances to food packaging. This is important since effective insulation is vital in order to solve the problem with climate change. Especially considering that buildings are responsible for 40% of energy consumption and 36% of CO2 emissions in the EU. Using Quartzene as thermal insulation in existing buildings in the EU could potentially lower CO2-emissions from heating and cooling by 42% (353 million tons per year). In the proposed project Svenska Aerogel will allow three European companies and one company from the Republic of Korea to perform the final verification of Quartzene® as insulation material on a tonne scale, in an operational environment. The project will also verify the final design of the first future full scale plants that Svenska Aerogel or its customers (through licensing agreements) aim to operate in the EU.By the end of the project, Quartzene® will be ready for commercial use as an insulation material (i.e TRL 9) and by Q2 2018 made available for a number of customers, some who have already signed agreements with Svenska Aerogel. The SME instrument will therefore be