RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Migration case study: transport of radionuclides in a reducing clay sediment'.

assistant: **Objectives**

For deep geological disposal of radioactive waste in clay, it is essential to consider the mobility of radionuclides. This proposal addresses the migration behaviour of radionuclides (U, Pu, Se and Am), identified as critical by Performance Assessment, in a reducing clay environment, with special emphasis on the role of the organic matter. Considerable attention is devoted to developing and demonstrating concepts describing radionuclide migration and the acquisition of the model parameters. An equal amount of effort is devoted to batch experiments, aimed at understanding the mechanisms behind the migration.Batch experiments revealed that the solubility of amorphous UO2 is ~10-8 mol dm-3 with no effect of NOM complexation. However, it was evidenced that the presence of NOM facilitated the formation of uranium colloids upon dissolution of UO2. The formation of colloids, with molecular size between 2 nm and 0.45 µm, accounts for a total uranium concentration, three orders of magnitude higher than the solubility of the amorphous UO2. These colloids, only evidenced in batch experiments, are unlikely to be mobile in the compact natural Boom Clay. Electromigration experiments showed that U(VI) reduces to U(IV) and precipitates. This U(IV) precipated phase constantly releases positive or neutral charged U-species. Furthermore, classical migration experiments with U(IV) mixed with 14C-labelled NOM showed that U(IV) migrates independently of the NOM through the Boom Clay. The migration of uranium in the Boom Clay is governed by strong retention due to precipitation (solubility limit) and sorption and is not enhanced by the mobile organic matter. Oxidised selenium species, as might be present in the waste forms, undergo a slow reduction in the Boom Clay. SeO42-, although thermodyn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ribosome Heterogeneity as a Determinant of Cellular Identity in Hematopoiesis and Leukemia', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Differentiation and acquisition of cell identity are fundamental processes in multi-cellular organisms. It is well established that chromatin and RNA mechanisms regulate cell fate determination. Mounting evidence from our lab and others, however, suggests that translation is an additional, until now underappreciated, determinant of cell fate. The importance of translation to differentiation can be gleaned from the hematopoietic system, where a prominent feature of human congenital syndromes, due to mutated ribosomes, is aberrant blood production. Crucially, these mutations lead to distinct cell-type-specific differentiation defects, rather than systemic failure. It remains unclear how congenital (total-body) ribosomal mutations only affect particular differentiation paths and manifest in a cell-type-specific fashion. We hypothesize that cell-type-specific ribosomal compositioni.e., ribosome  heterogeneityresults in cell-type-specific translation profiles, and therefore represents a crucial layer of gene regulation in cell-fate and differentiation. We will explore this hypothesis by pursuing three complementary objectives: (1) Systematically map ribosome heterogeneity and reveal its function in normal hematopoiesis and leukemia; (2) Determine how ribosome heterogeneity controls cell-type-specific translatomes and contributes to cellular transformation; and (3) Explore ribosome heterogeneity at single-cell resolution, using novel methodologies we will develop for simultaneous transcription and translatome interrogation. By combining cutting-edge sequencing techniques with extensive genetic manipulations in physiological settings, we will reveal cell-type-specific translation, controlled by cell-type-specific ribosomes, as major regulators of cell fate in health and diseas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Bio-inspired laser functionalization of complex 3D industrial surfaces'.

assistant: **Objectives**

Surface functionalisation is present in a wide range of sectors, improving the performance of multiple components and systems in many applications. However, when considering the application of such functionalisation in complex industrial parts, several challenges must be faced. The difficulty of reaching all surfaces of complex 3D parts is significative, especially in those with considerable size and weight. At the same time, uncertainty about the regulatory compliance of functionalised parts in some sectors makes a straightforward integration of this process more difficult. As a result, this limits the potential of some companies in terms of opening up new markets or attaining a competitive edge. Additionally, the creation of functional surfaces has traditionally relied on processes such as chemical reactions and/or the complete coating of the native surfaces (e.g. aerofoils). Due to their very nature, these processes generate unwanted by-products thereby leaving a significant environmental footprint, which go against the “do no significant harm” principle of The European Green Deal. In order to avoid these setbacks, a new functionalising process for complex 3D shaped parts in which the environmental footprint is reduced and where new guidelines are generated to complement the manufacturing standards of target sectors, could be a game changer. BILASURF aims at developing and integrating a process for high-rate laser functionalization of complex 3D surfaces using tailored designed bio inspired riblets to reduce friction and improve the environmental footprint of industrial parts, assuring a high throughput with the help of inline monitoring capabilities. This solution can provide European industry with a key tool to use a more efficient and environmentally friendly manu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Development of an anti-disease" vaccine and diagnostic tests for African trypanosomosis"'.

assistant: **Innovation**

The aim is to contribute to improvement of livestock productivity in DC through limitation of trypanosome-associated pathology and accurate diagnostics of trypanosome infections. It is proposed to develop immunisation strategies against pathogenic factors of trypanosomes (anti-disease vaccine). In a previous INCO project we focused on congopain, an immunosuppressive cysteine protease (CP) of Trypanosoma congolense. As the effects of immunisation with congopain are limited, association with other antigens is required. The current proposals expand the initial work to screening and characterisation of other pathogenic molecules, especially those responsible for anaemia. A number of other trypanosome proteases - CPs, serine and metallo- proteases - require characterisation as to their biological roles in the parasite and the host. Trypanosomes also contain protease inhibitors, some of which have immunomodulatory effects. They may thus be manipulated, directly or in association with their partner enzymes, to modulate the disease. Other, non-proteolytic, factors have been identified. The GPI (glycosyl phosphatidyl inositol) anchor of the T. brucei Variant Surface Glycoprotein is a major inducer of TNF, a cytokine that mediates anaemia. Finally, recent development in the field of proteomics and progress in the genome mapping of trypanosomes provide tools to study new pathogenic pathways. In order to improve diagnosis of the disease, procedures for antibody detection will be developed and/or validated. They are based on recombinant technology, which circumvent problems associated with the current use of parasite extracts. Recombinant and synthetic peptides from CPs and heat shock proteins, both previously identified as major antigens, as well as newly described molecules, will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Interoperable opeN-source Tools to Enable hybRidisation, utiliSation, and moneTisation of stORage flExibility' (INTERSTORE) under Horizon Europe.

assistant: **Objectives**

Storage is becoming one of the most critical assets for modern energy systems. At the same time storage is a very diverse universe of solutions and technologies with very different characteristics. InterSTORE plans to address this complexity by developing an innovative middleware that, while virtualising the storage technology, will simplify its use from the point of view of integration platform thanks to a technology agnostic approach.The middleware will facilitate the integration of storage creating an independence from hardware solutions which are critical from customer perspectives to avoid vendor lock-in solutions. It will also facilitate its use from a monetisation perspective making sure that more investments in storage are enabled.  InterSTORE middleware will be released as a full open-source product integrating a set of already available standards and protocols in a coherent and advanced architecture.The new InterSTORE solution will be tested and validated in a laboratory environment with the goal to develop testing software to be adopted in the future for interoperability certification.  The middleware solution will also be integrated both in open source and commercial platforms that will be integrated in 4 real life demos to enhance the flexibility platforms and analyze the user acceptance and economic value of the new solution. Moreover, new and legacy systems will be taken into account. InterSTORE also has a strong focus towards impact. The solution will become part of existing commercial platforms ensuring that a real adoption will be deployed beyond the end of the project. The consortium will ensure that software maintenance will continue beyond the end of the project with the support of Linux Foundation Energy and that the work done will be considered by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Modelling the neuromusculoskeletal system across spatiotemporal scales for a new paradigm of human-machine motor interaction'.

assistant: **Innovation**

Neurological injuries such as stroke leave millions of people disabled worldwide every year. For these individuals motor recovery is often suboptimal. The impact of current neurorehabilitation machines is hampered by limited knowledge of their physical interaction with the human. As we move, our body adapts positively to optimal stimuli; motor improvement after stoke is promoted via physical training with an appropriate afferent input to the nervous system and mechanical loads to muscles. Loss of appropriate stimuli leads to motor dysfunction.Motor recovery requires positive neuromuscular adaptations to be steered over time. If neuro-modulative and orthotic machines could be controlled to generate optimal stimuli to the neuromuscular system, a new era in neurorehabilitation would begin.This project creates multi-scale models of human-machine interaction for radically new closed-loop control paradigms. We will combine biosignal recording and numerical modeling to decode the cellular activity of motor neurons in the spinal cord with resulting musculoskeletal forces at a resolution not considered before. This will enable breakthroughs for tracking the spinal-musculoskeletal system across spatiotemporal scales: short-to-long term adaptation from cellular to organ scales. We will use these concepts to design new machine control schemes. With a focus on spinal cord electrical stimulation and mechatronic exosuits, we will demonstrate how motor dysfunction is repaired by inducing optimal changes in neuromuscular targets. The innovative aspect is that of gaining control of the stimuli that govern neuromuscular function over time. This will enable machines to co-adapt with the body; an achievement that will disrupt the development of man-machine interfaces from neuroprostheses, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'TRAINING NETWORK IN INNOVATIVE POLYELECTROLYTES FOR ENERGY AND ENVIRONMENT' (RENAISSANCE).

assistant: **Innovation**

The introduction of new ionic moieties (cations and anions) into polymers is giving rise to a new family of functional polymers with particular properties and new applications which is provoking a RENAISSANCE of the chemistry and applications of classic polyelectrolytes.   However, further developments and a better understanding of the properties and applications of innovative polyelectrolytes are still necessary to develop their actual and emerging applications. RENAISANCE will aim at excellence in developing high quality training opportunities through a synergistic collaborative research programme between industry and academia in the field of polymer science as applied to needs in Energy&Environment areas.RENAISSANCE  ITN allows the assembly of a truly world class multidisciplinary and intersectoral research and training network, capable to locate Europe at the forefront of emerging polyelectrolyte research. The six academic partners of the network (POLYMAT, LCPO, MPI CI, BIORGEL, ULg and IMDEA) and the four industrial participants (KITOZYME, PG B, PG I and REPSOL) are internationally renowned for their research and training activities in the fields of competence that they represent. RENAISSANCE training program includes local training activities such as individual research projects, PhDs, master courses, supervision and mentoring, specific local courses, as well as network-wide activities such as secondments, local courses open to the network participants, four workshops,one summer schools and one conference. Both scientific training and complementary skills training will be taken into account. The network will offer training to 11 Early Stage Researchers a 1 Experienced Researchers.  The ultimate goal will be to train ESRs as quality researchers, prepare them for po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bridging the gap between science, stakeholders and policy makers Phase 2:Integration of evidence-based knowledge and its application to science and management of fisheries and the marine environment' (GAP2) under Seventh Framework.

assistant: **Objectives**

GAP2 is about making a difference to an issue of significance to the whole of society; the wellbeing of the marine environment and the sustainability of fisheries upon which society depends for food. It builds on the relationships, processes and plans arising from GAP1 by enabling Mobilisation and Mutual Learning (MML) actions that promote stakeholder participation in the debate on and development of research knowledge and structures relevant to emerging policy on fisheries and the marine environment.A broad range of stakeholders will participate, including actors from civil society organisations, research institutions, universities, national and regional ministries and media organisations. Their work will involve: participatory research actions that integrate the knowledge of stakeholders and scientists and render it useful for management and policy development, critical evaluation of the participatory processes and incorporation of the lessons learned into systems of research and decision making. Global networks will be developed to enable trans- and international cooperation on comparing and establishing good practice.The actions of the participants and the outcomes from GAP2 will provide a concrete realisation of specific Science in Society objectives for engaging the public in research, enabling effective two-way communication between scientists and other stakeholders, and helping to make policy based on scientific evidence and research knowledge. It will contribute to the aim of the Science in Society programme to enhance democratic debate with a more engaged and informed public, by providing better conditions for collective choices on scientific issues relating to sustainable management, conservation of ecosystem integrity and biodiversity of the marine environme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Social Innovation Matched Crowdfunding (SIM Crowd)' under Horizon 2020.

assistant: **Concept**

The main objective of the proposed project is to conduct an experiment and test the effects of a “seal” (“funded by FFG”) and information about matched funding provided by a public funding organisation (FFG) on the funding decision of the audience on crowdfunding platforms. A randomised controlled trial (RCT) will be conducted within the existing funding scheme “Impact Innovation” of the Austrian Research Promotion Agency/FFG.FFG first launched a pilot scheme for a new programme called “Impact Innovation” in 2017. A second call with improvements in communication and evaluation criteria was carried out until autumn 2018. About 30% of proposals in these two pilot schemes addressed problems or solutions that were classified as “social innovation”. A recurring pattern in these proposals was lack of or failure to provide sufficient funding to cover the total cost of the project (FFG funds up to 50% of total project cost). In addition to this FFG received feedback from the community of social innovators that a significant number of ideas was not even submitted because the potential applicants could not generate or demonstrate the necessary funds to completely fund the project (100%).FFG therefore wants to test whether and how providing information on available public funding for social innovation projects will increase (or decrease) the chances to attract funding for the remaining 50% of project cost. This test will be run on a crowdfunding plattform for selected projects and – if the results are positive - increase the total amount of funding for successful social innovation projects and provide evidence for leverage effects of matched crowdfunding.


**Keywords:** Crowdfunding,  social innovation,  experimentation,  randomised controlled trial (RCT)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SEMEiotic Oriented Technology for Individual's CardiOmetabolic risk self-assessmeNt and Self-monitoring' under Seventh Framework.

assistant: **Concept**

According to medical semeiotics, human face is a precious revealer of key information about the healthy or unhealthy status of individuals, as a combination of physical signs and expressive features. The central idea in SEMEOTICONS is to exploit the face as a major indicator of individual's well-being for the prevention of cardio-metabolic risk and cardiovascular diseases (CVD), for which healthcare systems are registering an exponential growth of social costs.In accordance to a semeiotics viewpoint, face signs will be mapped to measures and computational descriptors, automatically assessed. To this end, SEMEOTICONS will design and construct an innovative multisensory system integrated into a hardware platform having the exterior aspect of a mirror: the so-called Wize Mirror". This will easily fit into users' home or other sites of their daily life (e.g. fitness and nutritional centres, pharmacies, schools and so on).The Wize Mirror will collect data mainly in the form of videos, images and gas concentration signals. These will be processed by advanced dedicated methods to extract biometric, morphometric, colorimetric, and compositional descriptors measuring individual's facial signs. The integration of such descriptors will provide a Virtual Individual's Model, which will be used to compute and trace the daily evolution of an individual's "wellness index".A well-being diary based on this index will enable users to evaluate and personally correlate the lifestyle to their wellness and health status. Suggestions and coaching messages will be also provided to foster the maintenance of a correct lifestyle or reduce noxious habits. Moreover, users will be enabled to share data in their diary with health professionals so as to receive, when needed, direct expert guidance and