RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Apatite-mediated electroporation for efficient delivery of siRNA in umbilical cord mesenchymal stem cells for safer allogeneic cell therapy'.

assistant: **Objectives**

Mesenchymal stem cells (MSC) isolated from the Wharton jelly of the umbilical cord (UC-MSC) show great potential for the use in allogeneic stem cell therapies for various human diseases. However,  the major limitation for the clinical use of allogeneic UC-MSC is their procoagulation activity, which is a consequence of expression of the tissue factor (TF), that can cause thromboembolism after transplantation, thus limiting their clinical usefulness. Preparation of UC-MSC without the TF (UCMSC-TF-) would enable safe clinical use of UC-MSC and bring their full therapeutic potential for treatment of patients. For this reason, preparation of UCMSC-TF- is the central goal of the “APApore4RNA” project. In the project, UCMSC-TF- will be prepared by utilizing the small interfering RNA (siRNA) directed against TF to silence the expression of TF. The project will develop a novel nanotechnology for ex vivo intracellular delivery of siRNA that will combine the use of biodegradable calcium hydroxyapatite (APA) nanoparticles (NPs) (fellow’s experience) and electroporation (EP) (experience of the company EDUCELL) to enable efficient, safe and reproducible transfection of UC-MSC. The use of APA NPs will be based on the fellow’s recent study published in Biomaterials that revealed their unique membrane-disruptive property that enables rapid permeation of payloads across plasma membrane. Moreover, as APA has low dielectric constant, it is expected that APA NPs will strongly improve the EP process by reducing the applied electric field required for reversible membrane permeabilization and consequently improve the safety and efficacy of EP. In addition, important goal of the “APApore4RNA” project is to gain fundamental knowledge about underlying mechanisms of APA-mediated electropermeabiliz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Uncovering the Origins of Mass: Discovery of the di-Higgs Process and Constraints on the Higgs Self-Coupling' (HiggsSelfCoupling).

assistant: **Innovation**

The Standard Model of particle physics describes the elementary constituents of matter and their interactions. In 2012, its last ingredient, the Higgs boson, was discovered at the Large Hadron Collider (LHC). The exploration of the Higgs boson is now one of the most exciting avenues to explore for New Physics beyond the Standard Model and allows some of the most pressing problems in theoretical physics to be addressed, such as the origins of the electroweak symmetry breaking mechanism. This important mechanism gives elementary particles their masses but the nature of this mechanism remains a mystery. A particularly crucial measurement is the production cross-section of Higgs boson pairs, which provides unique information on the Higgs self-coupling and on the underlying nature of the electroweak symmetry breaking mechanism. Most feasibility studies of the Higgs self-coupling conclude that there will be insufficient data for this measurement in the coming decade. However, my recent feasibility studies indicate that by using the Higgs pair production process with four bottom quarks in the final state, the discovery of the di-Higgs process and its cross section measurement can be made much earlier. This project aims to develop and complete the first measurement of the di-Higgs cross section and most stringent bounds on the Higgs self-coupling before 2023.To achieve this goal I will develop new experimental techniques to improve the background reduction rates and enhance the signal. The objectives are the development of novel bottom quark energy reconstruction algorithms, new bottom quark and Higgs identification techniques, and neural network analysis tools. Analysis of ATLAS data will then enable searches for New Physics and ultimately the di-Higgs cross section measuremen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CIRCular bio-based products for the BUILT environment' (CIRCBUILT) under Horizon Europe.

assistant: **Objectives**

The building and construction sector accounts for 37% of global emissions (2023). To mitigate the environmental impact of this sector, bio-based products are a promising solution especially when they are sourced from secondary bio-based materials. The CIRCBUILT project will gather 7 academic partners and 5 industries (SMEs mainly) for 36 months to propose a novel high value-added pathway for bio-based waste/residue sources of lignocellulose from the agricultural, agrofood and forestry industries, while being aligned with the cascading principles. Three novel intermediate components will act as main building blocks: foam-formed materials manufactured using two novel resource-efficient processes; first-of-a-kind thermochromic nanocellulose-based films and coatings; isocyanate- and formaldehyde-free bio-based binders as unique selling point on the adhesive market. This will serve as basis to the development and validation at TRL5 of four different types of products 100% made from secondary bio-based materials for the construction sector: 1) thermal insulation panels, 2) construction panels, 3) adapting cooling windows, and 4) indoor acoustic panels. Their technical performances will be comparable to their respective fossil-based benchmark, while unlocking the potential of circular value chains. A mock-up integrating the four products will be created for dissemination purposes, even to young generations of end-users. CIRCBUILT will engage with key stakeholders from the construction sector, as well as the broader cultural and artistic sector for going way beyond alignment with stakeholders’ requirements and NEB values; key stakeholders will be gathered in a Stakeholder Forum from the project’s beginning and actively participate in the products’ development and design creativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CLOUD Initial Training Network (CLOUD TRAIN)' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The aim of “CLOUD-TRAIN” is to establish a multi-site network of Early Stage Researchers (here predominantly PhD students) and Experienced Researchers at 10 partner institutions across Europe. The role of aerosol nucleation for atmospheric CCN levels, clouds and climate is investigated. The influence of various vapours and ions for aerosol nucleation, growth and cloud processes is studied to significantly improve our understanding of natural and anthropogenic climate forcing as well as feedback mechanisms.The major focus of the network will be three sets of common experiments on ternary nucleation (ion-induced and neutral) and ion-aerosol-cloud interaction carried out at CERN to which all trainees contribute. These experiments are conducted at the newly established unique aerosol chamber “CLOUD” that is exposed to a CERN ionizing particle beam where the effects of cosmic rays on aerosol and clouds can be efficiently simulated. At the CLOUD chamber nucleation experiments are performed at an unprecedented level of precision and completeness using highly innovative instrumentation.A comprehensive high quality training programme is set up for the fellows. Additional to the experiments at CERN, they are brought together for network training events such as annual summer schools and workshops for integral data analysis. Courses by world leading experts are taught spanning from general aerosol chemistry and physics to specialized sessions. The summer schools and workshops are specifically tailored to the needs of the trainees and are scheduled in addition to the national PhD programmes of their hosting institutions. Comprehensive transferable skills training is included (e.g. scientific writing, presenting talks, interaction with the media, entrepreneurship, IPR, management). F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'REgenerative therapy of intervertebral disc: a double blind phase 2b trial of intradiscal injection of mesenchymal stromal cells in degenerative disc disease of the lomber SPINE unresponsive to conventional therapy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The World Health Organisation (WHO) has included low back pain in its list of twelve priority diseases. Notably, Degenerative disc disease (DDD) presents a large, unmet medical need which results in a disabling loss of mechanical function. Today, no efficient therapy is available. Chronic cases often receive surgery, which may lead to biomechanical problems and accelerated degeneration of adjacent segments. Our consortium partners have developed and studied stem cell-based, regenerative therapies with encouraging results in phase 1 and 2a trials. Patients exhibited rapid and progressive improvement of functional and pain indexes by 50% within 6 months and by 65% to 78% after 1 year with no side effects. In addition, MRI T2 relaxation measurements demonstrated a significant improvement. To develop the world’s first rigorously proven, effective treatment of DDD, RESPINE aims to assess, via a multicentre, randomized, controlled, phase 2b clinical trial including 112 patients with DDD, the efficacy of an allogenic intervertebral mesenchymal stem cell (MSC)-based therapy. This innovative therapy aims to rapidly (within 3 months) and sustainably (at least 24 months) reduce pain and disability. In addition, the consortium aims to provide new knowledge on immune response & safety associated with allogeneic BM-MSC intradiscal injection. This simple procedure would be cost-effective, minimally invasive, and standardised.  The transfer to the clinic will be prepared at a cost below 10k€ thanks to the strategy of production of allogenic cells, automation & EU standardisation. At the end of the RESPINE trial, we aim to propose a broadly available and clinically applicable treatment for DDD, marketed by European SMEs.


**Keywords:** Degenerative disc disease, allogeneic MSC therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Secure information processing in quantum networks'.

assistant: **Innovation**

The promise of future quantum computers to substantially speed up computations has been advertised widely since the early days of the field. But there is a novel and fundamental aspect of devices based on quantum-mechanical principles that has just started to be explored: Quantum computers can preserve the privacy of computations. This aspect is a distinct new advantage of quantum computers over their classical counterparts. An entire class of unprecedented computations becomes feasible, in which the user data and the whole computation remain perfectly private – a feature impossible to achieve with classical computers. The main focus of this project is to exploit this feature and to implement secure photonic quantum information processing in distributed quantum networks. These networks consist of clients and small-scale quantum computers connected by communication channels. Photons are chosen as they are the ideal carriers for sending information over long distances. The clients can securely delegate computations to the quantum computers, such that neither the data nor the computation is revealed to the computers or any potential eavesdropper. The project will, first, elucidate how quantum resources boost the security of classical computations; second, demonstrate secure quantum computations over long distances and study their verification; and third, examine practical security aspects of implementations. The research will leverage the experimental state-of-the-art by adapting new photonic quantum technologies such as integrated photon sources and waveguide quantum circuits. Moreover, highly-efficient superconducting detectors will be applied to achieve excellent quantum control of the photons. This research is highly innovative and will be pivotal in the researcher’s c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enhancing sustainable chemical technologies through the synergy of computer simulation and experiment' under Horizon 2020.

assistant: **Concept**

The main aim of the ENACT project is to combine computer simulation with materials synthesis and experimental characterization to optimize the design of liquid-phase systems for chemical technologies. By optimization, we understand an improvement in efficiency, sustainability and environmental impact. The quest for such processes is rapidly becoming a necessity in a global scale. Air pollution, energy shortages, and global warming are very serious matters, whose remediation we embrace here as an integral part of the research agenda.This goal will be achieved by first gaining an understanding of the structural, dynamical, and thermodynamic properties of a variety of systems by means of computer simulation. This will allow us to tune their properties by modifying at will, in silico, the choice of materials and external conditions. This knowledge will be then transferred to the experimental partners who will synthesize and characterize the selected systems. If they do not perform as expected, or prove difficult or expensive to produce, a new computational cycle will be required. If they do work, simulation will be used again to fine-tune them. A particularly innovative aspect is that six independent themes will be tackled in parallel under a single umbrella, thus enabling the exchange of ideas and methods between them and paving the way to unexpected technologies arising from cross-fertilization between the various themes.This programme will be accomplished with the participation of four institutions: QUB (UK), UCD (Ireland), ISIS (UK) and UNCUYO (Argentina) with complementary expertise in various aspects of materials modelling, synthesis and characterization. To exploit in an optimal way this distributed expertise, a generous scheme of training (School and Workshops) and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Multi-agent Integration of Shared Statistical Information over the (inter)Net'.

assistant: **Objectives**

The Web has had a profound impact on the way National Statistical Institutes publish data. Europe is moving towards a global market and providers of official statistics will have to work in this context. MISSION aims to provide a software solution that will address the issues raised by this context. It will utilise the advances in statistical techniques for data harmonisation, the emergence of agent technology, the availability of standards for exchanging metadata and the power of Internet information retrieval tools. The result will be a modular software suite aimed at enabling providers of official statistics to publish data in a unified framework, and allowing users to share methodologies for comparative analysis and harmonisation. The modules are distributed over the web and communicate via agents. Several scenarios are possible including that of a third party Independent Metadata Provider.Objectives:A software suite allowing statistical data providers to publish data on the Web, satisfying the following criteria:(1) suppliers of official statistics can subscribe to an integrated network of datastores via an interface to their existing data;(2) suppliers retain control over all aspects of access to their existing data;(3) users can make requests in a declarative manner, with a minimum of understanding of statistics, or the domain area, and still retrieve meaningful results;(4) users can tailor their working environment, from simple requests to detailed in-depth analysis;(5) methods of data manipulation and analysis can be retained, re-used and published;(6) libraries of metadata can be constructed and made available to other users;(7) a flexible architecture allows third parties to act as Independent Metadata Providers, thus encouraging free exchange of knowledge;(8
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fish oil and meal replacement' (FORM).

assistant: **Innovation**

A Thematic Network on Fish Oil and Meal Replacement based on five existing EU-funded programmes, will be formed. Four network meetings will be organised, and new research results will continuously be added together with new information and informed comments to an Internet Site.While all projects represent important activities, there is a marked imbalance between effort on fish oil and -meal replacement. None of the projects considers food safety, or consumer health as a consequence of changed fillet composition stemming from changes in feed resources. There are no considerations of genetically modified feed resources, which may soon dominate the alternative feed resource market.The five projects are keen to widen the knowledge pool, by informed discussions with other authorities and stakeholders in the field of farmed fish, fish feed producers and bodies concerned with health and safety.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Lockdown Cohort-Effect: Does the unequal impact of the COVID-19 pandemic on fertility lead to long-term consequences for health and public services provision?' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The COVID-19 pandemic placed a heavy social and health burden on populations. Yet, because of social inequalities in the pandemic’s impact on fertility behaviour, babies conceived during the pandemic may be the most socially advantaged and healthiest birth cohort of the last decades. Research on this counterintuitive but realistic consequence of the pandemic – the Lockdown Cohort (LoCo)-Effect – is critical for public policy and the understanding of pandemic consequences.As individual-level register data for babies conceived and born in 2021 and later is only just becoming available, we still know little about how the pandemic changed the composition of parents and to what extent this explains changes in birth outcomes for those born during the pandemic. To address this knowledge gap, I will use individual-level register data (2010-2022) from Finland, Scotland, Austria, Spain, the United States, and Brazil and natural experimental methods to study the LoCo-effect comparatively. This strengthens the generalisability of results across different welfare regimes and pandemic experiences. First, I will study the magnitude of compositional changes in parental characteristics due to the unequal impact of the pandemic on fertility. Second, I will analyse the extent to which differences in prematurity and birth weight between the LoCo and earlier cohorts are caused by this change in parental characteristics. Third, I will estimate how the pandemic has affected intersectional social inequalities in birthweight and preterm birth.This project is innovative because it bridges disconnected debates in demography, epidemiology, and sociology to explain why, against expectations, pregnancy and birth outcomes have improved during the pandemic. As parental characteristics and birth outcom