RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Empirical Intrinsic Modeling for Nonlinear Signal Processing' (EMP-INT-MODEL-NL-SP) under Seventh Framework.

assistant: **Objectives**

A fundamental problem in signal processing is designing models, which are theoretically sound, practical to implement, and describe well the variability of real-world signals. Finding accurate models of signals sets the foundation to state of the art signal analysis, filtering, prediction, and noise suppression. In recent years there has been a considerable effort to derive data-driven modeling schemes based on low dimensional geometric analysis, however, several aspects have not yet been thoroughly addressed. For example, measuring the same phenomena several times usually yields different signal realizations. In addition, the same phenomena can be measured using multiple types of instruments. As a result, each set of related signal measurements of the same phenomenon will have a different geometric structure; this poses a limitation to geometric analysis methods. The goal of this project is to delve into these aspects and to devise empirical intrinsic models for nonlinear signal processing, which are noise resilience and invariant to the observation modality. Intrinsic models may bring significant benefits to numerous applications without existing definitive representations by enabling the fusion of similar phenomena partially observed through different modalities. The availability of intrinsic models will allow for the design of new processing methodologies that take advantage of the intrinsic properties, e.g. noise robustness and low dimensionality. I will examine both theoretical and practical aspects as well as develop tools designed to push forward the applicability of geometric analysis. Combining my experience with the expertise in related fields provided by the host institution will allow to advance the current state of the art in geometric signal analysis and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of RGD-therapeutics for cardio-metabolic disease' (RGD-Diabetes), addressing dissemination and exploitation.

assistant: **Impact**

In Europe, 58 million people are living with type 2 diabetes and 36 million people are at risk of developing the condition. Macrovascular disease is the commonest cause of morbidity and mortality in type 2 diabetes, yet current diabetes therapies have failed to consistently reduce cardiovascular events. In my Starting Grant, I discovered that a circulating protein, IGF binding protein-1, possesses several favourable characteristics– including insulin sensitisation, amelioration of glucose intolerance, blood pressure lowering, reduced atherosclerosis and increased vascular repair. These effects are mediated by interaction of the protein’s RGD-domain with cell-surface α5β1 integrin receptors, which increases insulin-stimulated glucose uptake in skeletal muscle cells and glucose-stimulated insulin secretion in pancreatic islets. Hence the ‘idea’ from my Starting Grant is that RGD-integrin interaction could be exploited therapeutically in diabetes.  In this Proof-of-Concept grant, we will take the first step towards commercialisation of the idea by designing and testing small molecule mimics of the RGD domain of IGFBP1 as diabetes therapeutics. Using in silico modelling based on the known structures of IGFBP1 and the α5β1 integrin ectodomain, we will design a small molecule library of commercially available potential agonists. We will carry out virtual high throughput screening of the library for molecules matching the shape and electrostatic potential of the RGD domain of IGFBP1 as predicted to bind to α5β1 integrin. As contingency, we will also identify in silico ‘me-too’ analogues of known integrin ligands. We will test the best quality hits through ADME profiling and validate therapeutic activity in vitro and in vivo. At the end of the project, we anticipate we will hav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Emitter-mediated Photon-Phonon InteraCtion' (EPPIC), addressing dissemination and exploitation.

assistant: **Impact**

This action, “Emitter-mediated Photon-Phonon InteraCtion” (EPPIC), will contribute to the research areas of quantum computing and quantum sensors. These are key areas of the quantum technologies flagship initiative, which has the goal of establishing Europe as a leader in the second quantum revolution and its future industrial exploitation.The focus of EPPIC is on III-V semiconductors due to their compatibility with industrial nanofabrication. Implementing quantum bits in such semiconductors typically relies on the optical control of single spins in local potential traps (expertise of the host). These traps are called quantum dots (QDs). In order to carry out computations using QDs their behavior needs to be well controlled. Continuous interactions with an uncontrolled environment have a “distracting” influence on the QD and lead to a phenomenon known as decoherence. Overcoming decoherence is a major challenge in developing quantum technologies. In this action novel optomechanical and purely mechanical nanostructures will be designed and realized in order to shield QDs from some of the light (optics) and sound (mechanics) in their environment (expertise of the applicant). Once achieved, resonators can be designed that make the QDs interact strongly with specific frequencies of light and sound. The aim of EPPIC is to demonstrate that these nanostructures can manipulate the optical and spin-dynamics of a QD and that optical control of the QD can be used to manipulate the state of an isolated mechanical resonator. These accomplishments will lay the ground work for future projects: to create nonlinear elements for optomechanics; mediated QD-QD interaction by a common mechanical mode; achieve ground-state cooling of a mechanical resonator via optical control of a single QD;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Probing DC-SIGN-glycan multivalent interaction and dendritic cell immune regulation using polyvalent multifunctional glycan-gold nanoparticles' (Glycan-PMN).

assistant: **Concept**

Multivalent lectin-glycan interactions is central to pathogen infection and immune response regulation. Dendritic cell (DC) surface tetrameric lectin, DC-SIGN, is particularly important in discriminating self- and foreign (pathogen) glycan patterns and regulates DC immune response. The underlying structural and immune regulation mechanisms remain poorly understood. As various lectins have overlapping glycan specificity, this greatly limits our ability to design glycoconjugates that can specifically target DC-SIGN to block infection or exploit its powerful immune regulation to develop effective immunotherapies.Here we will address this challenge by developing polyvalent glycan-gold nanoparticles (GNPs) & multiple GNP assemblies to enhance binding affinity and specificity by exploiting multivalency. By tuning GNP surface glycan structure, valency, inter-glycan spacing, size and shape and study their binding with DC-SIGN/R, we will reveal the optimal glycan structure for DC-SIGN binding. By exploiting GNP’s fluorescence quenching, we will develop a new lectin-glycan affinity quantifying method. We will use glycan-GNPs to block pseudo-Ebola virus infection of DC-SIGN expressing cells and correlate the affinity and inhibition potency. We will study how glycan-GNP binding controls DC surface DC-SIGN clustering, binding to intracellular proteins & regulating cytokine production to reveal the . This research is extremely timely & important because it will, 1) establish a design rule for potent, highly specific DC-SIGN targeting; 2) develop a new lectin-glycan affinity quantification method; 3) reveal correlation between DC-SIGN/R binding affinity & viral inhibition potency; 4) elucidate how DC-SIGN-glycan binding signal is transduced to regulate DC immune function, paving way t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Genetics of mosquito resistance to pathogens' (AnoPath), addressing dissemination and exploitation.

assistant: **Impact**

Malaria parasite infection in humans has been called “the strongest known force for evolutionary selection in the recent history of the human genome”, and I hypothesize that a similar statement may apply to the mosquito vector, which is the definitive host of the malaria parasite.  We previously discovered efficient malaria-resistance mechanisms in natural populations of the African malaria vector, Anopheles gambiae.  Aim 1 of the proposed project will implement a novel genetic mapping design to systematically survey the mosquito population for common and rare genetic variants of strong effect against the human malaria parasite, Plasmodium falciparum.  A product of the mapping design will be living mosquito families carrying the resistance loci.  Aim 2 will use the segregating families to functionally dissect the underlying molecular mechanisms controlled by the loci, including determination of the pathogen specificity spectra of the host-defense traits.  Aim 3 targets arbovirus transmission, where Anopheles mosquitoes transmit human malaria but not arboviruses such as Dengue and Chikungunya, even though the two mosquitoes bite the same people and are exposed to the same pathogens, often in malaria-arbovirus co-infections.  We will use deep-sequencing to detect processing of the arbovirus dsRNA intermediates of replication produced by the RNAi pathway of the mosquitoes. The results will reveal important new information about differences in the efficiency and quality of the RNAi response between mosquitoes, which is likely to underlie at least part of the host specificity of arbovirus transmission.  The 3 Aims will make significant contributions to understanding malaria and arbovirus transmission, major global public health problems, will aid the development of a next ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From associations to rules in the development of concepts' (FAR).

assistant: **Concept**

Human adults appear different from other animals by their ability to use language to communicate, their use of logic and mathematics to reason, and their ability to abstract relations that go beyond perceptual similarity. These aspects of human cognition have one important thing in common: they are all thought to be based on rules. This apparent uniqueness of human adult cognition leads to an immediate puzzle: WHEN and HOW does this rule-based system come into being? Perhaps there is, in fact, continuit y between the cognitive processes of non-linguistic species and pre-linguistic children on the one hand, and human adults on the other hand. Perhaps, this transition is simply a mirage that arises from the fact that Language and Formal Reasoning are usua lly described by reference to systems based on rules (e.g., grammar or syllogisms). To overcome this problem, we propose to study the transition from associative to rule-based cognition within the domain of concept learning. Concepts are the primary cog nitive means by which we organise things in the world. Any species that lacked this ability would quickly become extinct (Ashby & Lee, 1993). Conversely, differences in the way that concepts are formed may go a long way in explaining the greater evolu tionary success that some species have had over others. To address these issues, this project brings together 5 teams of leading international researchers from 4 different countries, and with combined and convergent experience in Animal Cognition and Evo lutionary Theory, Infant and Child Development, Adult Concept Learning, Neuroimaging, Social Psychology, Neural Network Modelling, and Statistical Modelling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Multi-perspective Ultrasound Strain Imaging & Elastography'.

assistant: **Concept**

Ultrasound (US) is the modality of choice for imaging and functional measurements of the cardiovascular system due to its high spatial and temporal resolution. In recent years, the use of US has been on the rise owing to huge advancements in acquisition speed and resolution. Nevertheless, because of physical constraints, several issues —limited field-of-view, refraction, resolution and, contrast anisotropy— cannot be resolved using a single probe. This proposal will aim at tackling these issues introducing Multi-perspective Ultrasound Strain Imaging & Elastography (MUSE). MUSE will push the frontiers of 3-D US imaging by introducing a novel, multi-perspective 3-D US system. The revolutionary system will consist of two synchronously controlled 3-D matrix arrays and advanced signal and image processing to improve geometric and functional measurements (strain, elasticity). Validation will be performed for two applications: cardiac strain imaging in patients with aortic valve stenosis (AoS) and elastography of abdominal aortic aneurysms (AAA).Fusion of dual-probe data will be challenged and achieved by new algorithms, preserving important features and improving both contrast and field-of-view. Advanced 3-D processing of the raw US data will be developed for motion and strain imaging. A novel compounding technique, fusion strain imaging, will combine multi-perspective strain data to improve accuracy and precision. A comprehensive framework for system verification and validation will be built, comprising US simulations, ex vivo experiments, and in vivo pilot studies on healthy volunteers. The proposed technique will be validated in AoS and AAA patients. Ultimately, MUSE will introduce a non-invasive, ground-breaking US platform for functional screening and follow-up, and a br
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Commercialising High Performance Insect Breeds via a Platform for Typing of Insect Strains' (CHiPInB) under Horizon 2020.

assistant: **Objectives**

Beta Bugs is the first insect breeding company focussed on creating high performance Black Soldier Fly (BSF) genetics for the rapidly emerging ""insects as feed"" market. This global market has received more than €480M in investment from private and public sector funders, and will be worth €2.15Bn by 2030. It also enables valorization of low-value food and agricultural waste streams into localized protein sources suitable for animal feed, making it of strategic importance to the EU's future food security since it will strengthen regional agri-food supply chains.The company proposes a solution which combines proprietary trait generation methods, quantitative genetics and selective breeding, and high throughput phenotyping (trait measurement) using proprietary technologies. The company has developed a proprietary PLATform for TYPing of Insect Strains (PLATYPIS), which combines modular rearing technologies that enable parallel maintenance of diverse strains, and high-throughput phenotyping of the insects. This provides an opportunity for targeted genetic improvement efforts in BSF that can significantly improve BSF producer productivity (e.g. faster growth rate) and BSF protein quality (e.g. nutritional profiles tailored to different livestock). As the first company focusing solely on genetics and catering to the whole market rather than in-house applications for one producer, this solution is uniquely placed to benefit from EIC Accelerator Funding. This will enable the skilled, specialized and committed Beta Bugs team to commercialize this solution, transforming the company into a highly impactful and profitable venture, capture significant market share and accelerate the development of the entire ""insects as feed"" industry. ""


**Keywords:** Insect breeding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrating and decentralising diabetes and hypertension services in Africa' (INTE-AFRICA) under Horizon 2020.

assistant: **Objectives**

We will integrate and scale up services for diabetes and hypertension in clinics in Tanzania and Uganda, either as standalone or  integrated with HIV-infection. This builds on pilot studies that the partners are conducting, funded by UK NIHR, on the prevention and management of HIV, diabetes and hypertension in Africa. The aim of INTE-AFRICA is to assess the effectiveness and feasibility of large-scale scale up. Research evidence needed by African health services to scale-up and sustain the screening and management of diabetes and hypertension in different settings will be generated.  The objectives include: to re-organise primary health care services so that diabetes and hypertension can be diagnosed and treated in dedicated chronic care clinics in two large regions, one in Tanzania and in Uganda; to decentralise care from health facilities to the community in order to reduce patient load at clinics and reduce reliance on (scarce) clinical staff; to evaluate these approaches in terms of acceptability (by patients and the community), numbers of patients treated and retained in care, patient clinical outcomes (blood pressure control, blood glucose control), costs of delivering integrated care for the health service and cost-effectiveness (compared to current standard care); to use the data generated to contribute evidence to the development of clinical guidelines; to develop the sustainable partnerships needed between researchers, government policy makers, public-private partnerships on an ethos of openness and equality so as to facilitate the expansion of the scale-up nationally. The majority of individuals with either hypertension or diabetes  are identified after they develop complications, which leads to their poor outcomes, and to catastrophic costs to both the heal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Linking biological and artificial neuronal assemblies to restore lost brain functions: towards the design of innovative bi-directional neuroprostheses'.

assistant: **Concept**

The possibility to control actions from thoughts is becoming reality thanks to Brain Machine Interfaces (BMIs). However modern BMIs are mostly unidirectional and aimed at restoring lost motor functions. In a wider perspective, neural interfaces must be bi-directional devices that substitute motor, sensory or cognitive circuits within the brain, that might have been damaged as a result of an injury or a disease. The project goes towards this direction: it will provide the knowledge to realize a new class of neuroprostheses aimed at treating those diseases where a portion of brain tissue is damaged (e.g. lesion). The ultimate goal of the project is to connect in vitro neuronal assemblies to an artificial system (a neuromorphic chip) which aims at restoring the lost neuronal functionality, with the long-term perspective to be implanted in humans affected by invalidating brain diseases. This will allow us to reach three main scientific objectives: (i-DECODING) improve the performance of BMIs by investigating optimal decoding schemes to extract useful information by multisite acquisitions from neuronal assemblies; (ii-PROCESSING) provide an artificial link between two previously connected assemblies by designing computational models (sw and hw) which mimic the behavior of the injured part of the network; (iii-CODING) design new strategies by developing stimulation protocols aimed at effectively sending appropriate information to cell assemblies. These goals will be reached by using an engineering approach to neuroscience: a fully controlled and measurable experimental system where the 'biological' neural element will be investigated at different levels of anatomical complexity: from random, unstructured circuits up to the intact brain. Thanks to this approach we will be able