RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'First line randomized study platform to optimize treatment in patients with metastatic renal cell carcinoma' (CARE1) under Horizon Europe.

assistant: **Objectives**

In 2020, there were an estimated 431 288 new cases of kidney cancer (Renal Cell Carcinoma, RCC) globally with 138 611 cases in Europe, leading to 179 368 deaths worldwide, including 54 054 deaths in Europe (source: IARC/Globocan). To define high priority topics in academic research and launch dedicated trials, European RCC academic physicians have gathered into a European initiative – the CARE group.  Systemic therapy for RCC relies on two classes of agents: anti-angiogenic targeted therapy (Vascular endothelial growth factor Tyrosine Kinase Inhibitor- VEGFR TKI) and immune checkpoint inhibitor (ICI), targeting either PD-1/PD-L1 axis or CTLA-4. Combination therapy is standard of care (SOC) for clear cell RCC in all guidelines with either ICI-ICI or ICI-VEGFR TKI.  However, no head-to-head comparison have been performed between the two approaches and patients are treated based on physician decision without clinical or biomarker factors to guide treatment selection. PD-L1 staining is, to date, the biomarker that has demonstrated its ability to enrich for overall survival benefit favoring ICI-ICI strategy in PDL1(+) and ICI-VEGFR TKI in PDL1(-) patients.CARE1 PCT is a prospective randomize phase III study, in first line setting for patients with metastatic clear cell RCC comparing ICI-ICI vs ICI-VEGFR TKI approaches stratified on PD-L1 by local determination.  Primary endpoint is overall survival (OS). The trial will enroll 1250 patients over 3 years across eight European countries that are part of the CARE consortium. Study Sponsor is Gustave Roussy institute within the GETUG network for France, co-sponsor is developed through main academic networks (eg. SOGUG in Spain) and main institutions across Europe (eg. Cancer Core Europe – CCE).  Study design has been develop to d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New technologies for predicting the occurrence of high-grade gold ore shoots' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The proposal identifies a very important problem common to all SME mining companies exploring for low- to- medium tonnage vein- type mesothermal gold deposits; namely the difficulty in locating and evaluating high grade gold shoots, which critically determine the economic viability of these deposits. gold grades tend to be erratic and highly variable. though potential areas of gold mineralization at a regional scale can be identified using conventional exploration techniques, current metallogenic models do not provide the necessary vectors for locating discrete high grade zones. This increases investment risk and discourages exploration. The aim of the project is to develop a predictive capability for detecting and evaluating high- grade gold ore shoots using new, cost effective analytical and software technologies. Substantial evidence has been assembled which suggests that high- grade gold ores (or zones) are the result of remobilization and enrichment by later, lower temperature fluids. The technical goals of the project are to develop novel methods for identifying the presence of diagnostic 'fluid inclusion- mineral- microstructural' markers in diamond drill core that relate to this fluid overprinting. to provide practical exploration vectors, these markers will be integrated advanced geostatistical models which incorporate process information enabling 3D visualization of the deposit and better procedures for resource estimation and mine planning. Post- project exploitation of the RTD results by the SME mining company will commence immediately with respect to their EU deposits; progressively extending the exploration potential to other EU and eastern European countries. intended commercialization of the RDT products includes automation of the detection methodologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Facilitating Collaboration in ReseArch and Development to Foster Further Innovation in European AeroNautics' (RADIAN) targeting Horizon 2020.

assistant: **Abstract**

Aviation is a vital industrial sector of Europe’s society and economy. For several historical reasons the economic activities in this field are unevenly distributed across Europe. Statistics show that also the R&D effort, which always comes along with the aviation, mirrors this allocation. On one hand, there are countries and regions featuring low involvement in aviation research and also low participation in the EU Framework Programmes; on the other – some regions are heavily involved in aviation R&D and are origin of wealth and prosperity.RADIAN is a multi-step project which intends to overcome this misbalance by identification of barriers for international collaboration in aviation research at EU level and by subsequent development and verification of solutions and measures on level of the European regions.The initial step is to assess the impact of regional, national and international environment on aviation actors. An impact is considered to become a “barrier” in case it has a detrimental nature or significantly differs from the pan-European average. By systematically comparing single impact scenarios for various actors located in different  European regions, barriers for cooperation will be identified.Having this verified knowledge, 12 target regions are identified to derive, verify and execute tailored activity plans aiming at the enhancement of the actor’s ability to cooperate by reducing the disadvantageous impact or by the advancement of actor’s own assets, knowledge and abilities. Another field of work of RADIAN is a self-sustaining collaboration platform which acts as a host for transnational exchange. The platform aims at becoming a live portal, for providing personalised information related to the users’ interests such as open calls, available funding sche
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Demonstrating a cost competitive, sustainable, scalable intensified micro-algae bioprocess for the production of food-grade medium value, carbon negative Ingredients exceeding Market Standards' (CleanAlgae2Value) under Horizon Europe.

assistant: **Objectives**

Micro-Algae offer a solution to many of the European bioeconomy needs. Nevertheless, significant challenges still exist to their acceptance on the market, including organoleptic and functionality challenges. CleanAlgae2Value seeks to unlock such potential via a cascading approach to white-microalgae-derived medium-price ingredients, including protein isolates, oils, natural pigments and starch. The project will build and operate a replicable “upgrading-module” to drastically enhance relevant biorefineries performance via a cost-competitive, sustainable, and scalable microalgae fractionation and valorisation process for producing food-grade, medium-value, carbon-negative ingredients that exceed market standards. More specifically, the project will prove the effectiveness and efficiency of a “Micro-Algae Biorefinery Upgrade Module” (MABUM), able to unlock productions of protein isolates, protein concentrates, starch-rich fraction and oils (respectively 2, 1.3, 3.98 and 1.8 tons) to be validated into 15 prototypes, 13 for food and 2 for bio-packaging markets. The project will do so while increasing operative margins, by decreasing “value-normalised” CAPEX and OPEX, also thanks to modelling optimisation, contributing to market penetration. Importantly, CleanAlgae2Value would also benefit from synergies with a recently granted EIC Accelerator project, which focuses on upstream algae production from CO2 via SOL two-step fermentation, using solely CO2 as carbon source. The project brings together 16 organizations from 9 European countries, collaborating with end-users to produce added value ingredients. Holistic evaluations, including both empirical (surveys, workshops) and horizontal considerations (LCA, TEA, SSbD), will allow for the assessment of market acceptance and envir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Gut microbiota-Microglia Interactions in NeuroDevelopment'.

assistant: **Innovation**

Childhood psychiatric disorders are alarmingly common, yet current gold-standard treatments fall short in creating lasting, meaningful improvements for many individuals. To improve outcomes, it is imperative to enhance our understanding of pathways to disordered development. Recent advances in the study of microglia-neuron interactions and critical period signals suggest that disruption in the developmental timing of these neural events may contribute to early-onset psychopathology. However, the factors that modulate these signals have not been well-defined. The GutMIND project will test the hypothesis that complementary maturation of the microbiota and the brain during critical windows of development may be one contributing factor. For the first time, the (sex-specific) trajectory of the microbiota’s influence on behavioural and neural outcomes during early host development will be characterised in detail. This will generate testable hypotheses regarding potential mechanisms and thus potential treatments to ameliorate the effects of microbiota depletion during critical periods. Specifically, this will be achieved by experimentally testing 1) metabolite pathways that may contribute to the microbiota’s influence on microglia-neuron communication and 2) the mediating role of the microglia in microbial influences on behaviour. In line with the objectives of the MSCA fellowships, the research project has been designed to facilitate the applicant’s career development by providing advanced training in supportive host environments that will diversify her research competencies, foster her managerial and teaching skills, and strengthen her research profile and professional network. In the process, public, industry, and scientific audiences will be engaged in the outcomes of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Foot-and-mouth disease virus: the molecular basis of tissue tropism and persistence'.

assistant: **Innovation**

Foot -and-mouth disease virus (FMDV) causes a highly infectious, vesicular disease in cloven hoofec animals. In ruminants the acute phase is often followed by an asymptomatic, persistent infection. This elusive infection also arises in vaccinated animals exposed to FMDV. The risk posed by such carrier animals is the crucial barrier to the use of vaccines in Europe for emergency disease control. In recent years we have learnt much about where the virus persists in carriers, and about mechanisms of host cell recognition in vitro. By linking and extending these two areas of research, this project aims to elucidate the molecular mechanisms underlying viral tropism and persistence in the natural host. This project, which combines molecular virology, immunology, and state-of -the-art histopathology, will provide vital intelligence in the war against FMD by revealing targets for therapeutic or immune intervention aimed at preventing, or curing, the carrier state.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'THEORETICAL ANALYSIS, DESIGN AND VIRTUAL TESTING OF BIOCOMPATIBILITY AND MECHANICAL PROPERTIES OF TITANIUM-BASED NANOMATERIALS' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The goal of this project is to develop multiscale theoretical models of biocompatible metallic nanomaterials and apply them for the analysis, design and optimization of the materials.  Two groups of titanium based nanomaterials are considered (while the methods developed should be applicable to other metallic materials as well): nanostructured commercially pure titanium and shape memory NiTi alloy. The multiscale model of nanostructured titanium (nTi) includes atomistic molecular dynamics (MD) discrete dislocation dynamic model (DDD) of the nucleation, interaction and movement of dislocations, crystal plasticity models mechanical behavior of Ti nano-grains, coupled texture and substructure evolution model for severe plastic deformation of polycrystalline Ti, micromechanical analysis of the grain sizes and microstructures on the mechanical properties. The atomistic and micromechechanical modeling of martensitic transformation (or reorientation) lattice strain of NiTi alloys is carried out.  The biocompatibility of these two groups of materials (MD modeling of the interactions between metallic nanoparticles and biological molecules) is studied theoretically. The theoretical studies and recommendations are validated experimentally and in practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Direct Statistical Simulation of the Sun and Stars' under Horizon 2020.

assistant: **Concept**

This proposal (D5S) addresses a key problem of astrophysics – the origin of magnetic activity in the sun and solar-typestars. This is a problem not only of outstanding theoretical importance but also significant practical impact – solar activity hasmajor terrestrial consequences. An increase in activity can lead to an increase in the number and violence of solar flares andcoronal mass ejections, with profound consequences for our terrestrial environment, causing disruption to satellites andpower. Predictions of magnetic activity are highly desired by government and industry groups alike. A deep understanding ofthe mechanisms leading to solar magnetic activity is required. The variable magnetic field is generated by a dynamo in thesolar interior. Though this mechanism is known to involve the interaction of magnetohydrodynamic (MHD) turbulence withrotation, no realistic model for dynamo action currently exists. D5S utilises two recent significant breakthroughs to constructnew models for magnetic field generation in the sun and other solar-type stars. The first of these involves an entirely newapproach termed Direct Statistical Simulation (DSS) (developed by the PI), where the statistics of the astrophysical flows aresolved directly (enabling the construction of more realistic models). This approach is coupled to a breakthrough (recentlypublished by the PI in Nature) in our understanding of the physics of MHD turbulence at the extreme parameters relevant tosolar interiors. D5S also uses the methodology of DSS to provide statistical subgrid models for Direct Numerical Simulation(DNS). This will increase the utility, fidelity and predictability of such models for solar magnetic activity. Either of these newapproaches, taken in isolation, would lead to significant progress in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enough to feed an army. Carthaginian rural exploitation during the late third century BC' (ETFA), addressing dissemination and exploitation.

assistant: **Impact**

Between 237 and 202 BC, the Carthaginian Empire due to both its territorial ambitions and, above all, its conflicts with Rome and several indigenous peoples of the Iberian Peninsula and North Africa, was forced to keep large numbers of troops permanently mobilized. This military-political circumstance led to a series of major changes in many areas of the Carthaginian economic, political and social system. Through this project we will analyze in detail the extent to which the military mobilization affected agriculture, the very basis of the ancient economy, and the related politics adopted by the ruling elites of the Carthaginian Empire. This project, therefore, includes a quantitative study of the productive capacity of the Carthaginian empire in the late third century BC; an analysis of the logistics during the Second Punic War (218-201 BC); an appreciation of the relationship of war veterans with agricultural production at this chronological context; and a comparison of these results with those obtained in a specific casus: a survey of part of the territory under the rule of the Phoenician city of Utica, a North-African city under the Carthaginian rule.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Unrivalled AI powered document handling and data extraction system'.

assistant: **Innovation**

For any SME, document management becomes a nightmare once it starts to grow and generates vast amount of legal and financial documents. The implications of improper document management range from missing/lost documents to unfavourable business decisions to non-compliance. To solve this problem, other companies have launched (intelligent) document management solutions (DMS), but these products often come with several drawbacks, e.g., product being project based and for large corporations, not plug-n-play (requires extensive pre-training), and still requires manual input from employees (not fully automatic). These drawbacks cause the existing solutions to become expensive, inefficient and time consuming, in turn, forcing SMEs to opt out.ARCHII, a Danish SME, was founded solely to fulfil this unmet need of a highly accurate, efficient, fully automatic and cheap DMS for SMEs worldwide. The resulting solution - “Archii” - relies on artificial intelligence to identify and organize legal and financial documents. Archii has been trained with 50 thousand real company documents making it the only fully plug-n-play DMS for legal and financial documents available in the market. Archii finds and organizes documents by analysing its content (irrespective of location and filename) with 95% accuracy. Also, Archii converts information from inside each document into actionable intelligence (e.g. contracts’ expiry, GDRP risks etc.).To commercialize Archii in 2021 and to penetrate a market worth 7$B, ARCHII needs to (1) improve product-market fit; (2) develop a generic, scalable business model; and (3) demonstrate and document the benefits of Archii to increase market awareness. These comprise the innovation project objectives (Phase-1 and -2). By successfully achieving these objectives, A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Researcher's night in Slovakia 2009:' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project is based on warmly welcomed previous Researcher’s Night 2007 and 2008 experience. This activity of the EC is from year to year more and more popular in Slovakia among variety stakeholders – going from policymakers, top-level representatives from academic institution to individual research and general public. We still see the room for improvement and therefore we decided to change overall strategy of the project in the following way: - researchers as ordinary people - as level of awareness of activities during the night is already on very good level, we are able finally to put desired focus on researchers as ordinary people (previous years were different, as we needed to put in front of the project science shows in order to attract for the first time ever in Slovakia more people on such event); - regionalization of the events in 2009 project; - breakthrough in awareness campaign in 2009 – based on the previous experience, we are going to diversify the awareness campaign activities in order to reach even better impact and more people than in the previous years. The change of the strategy fully reflects previous years’ evaluation reports of RN project proposals for Slovakia. Our main reason behind the change of the strategy is to make the impact of the project maximum possible. The project will be integral part of several days lasting science festival in Slovakia and will be the most important part of it. Reaching of the objectives will be carefully evaluated in the impact assessment activities. Activities during the night will fully reflect the above mentioned strategy and will be as follows: - Poster Competition: Imagine the Researchers´ Night 2010 - Photo Exhibition for Researchers - Drawing Competition - Main event – Researchers´ Night in Slovakia 2009: Sci