RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reconstructing Scribal Vernacular Practices. Coptic Correspondence and Vernacular Scribal Practices in Late Antique and Early Islamic Egypt.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

RSVP aims at reassembling the rich world of scribal practices in Coptic letter writing between the 4th and 11th centuries CE. It offers an ambitious reconstruction of epistolographers’ habits, networks, and cultural identities when Coptic was the vernacular Egyptian language employed alongside official idioms (Greek and Arabic).Using a multidisciplinary approach combining paleography, digital humanities, and sociolinguistic analysis, RSVP will analyze for the first time a corpus of over 5000 Coptic letters along four axes: 1) Challenge established views on vernacular practices through expanded Coptic letter analysis. 2) Investigate literacy, paleography, and writing practices in relation to cultural and linguistic shifts. 3) Identify dialectal variation and code switching through linguistic analysis, illuminating the period’s complex linguistic landscape. 4) Assess published Coptic letters’ impact on social cohesion and power dynamics on a diachronic and countrywide scale.RSVP will contribute to papyrology, Coptology, and digital humanities, by reassessing writing culture, multilingualism, and epistolary étiquette, while applying digital approaches for large-scale analysis of ancient documents and open-linked data (e.g. OCR for semi-automatic text encoding and digital paleography for handwriting identification). Social historians of Antiquity and early medieval times will also have access to a nuanced understanding of cultural continuity and change during a crucial period of political and cultural transition between Byzantium and Islam, enhancing understanding of provincial life, local elites, villagers, and women’s roles.By reconstructing letter-writing practices in Coptic, RSVP will refocus scholarship on overlooked historical sources, shedding new light on epistologr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Metabolic actions of brain leptin receptors signaling in type 1 diabetes' under Seventh Framework.

assistant: **Concept**

An established dogma is that insulin is absolutely required for survival. This notion has been supported by the fact that the sole life-saving intervention available to the millions affected by type 1 diabetes mellitus (T1DM; an illness caused by pancreatic β-cell loss and hence insulin deficiency) is insulin therapy. This treatment however does not restore normal metabolic homeostasis. In fact, the life-expectancy and -quality of T1DM people is worse compared to normal subjects. In part, this is due to challenging morbidities of T1DM, as for example heart disease and hypoglycemia, both of which are thought to be caused by insulin therapy itself. Indeed, owing to insulin’s lipogenic actions, this treatment likely contributes to the ectopic lipid deposition (i.e.: in non-adipose tissues) and extremely high incidence of coronary artery disease seen in T1DM subjects. Also, due to insulin’s potent, fast-acting, glycemia-lowering action, this therapy significantly increases the risk of hypoglycemia; a disabling and life threatening event. Because insulin therapy does not restore metabolic homeostasis in T1DM subjects, better intervention is urgently needed. To these ends, we and others have shown that the hyperglycemic and lethal consequences of insulin deficiency can be rescued by administration of the adipocyte-secreted hormone leptin. Not only these results challenge an established view, they also raise a fundamental biological and medical question: what are the mechanisms by which leptin improves hyperglycemia and permits survival in the context of insulin deficiency? This proposal aims at identifying the critical cellular and molecular components underlying the beneficial effects of leptin in the context of insulin deficiency. Once identified, manipulation of these comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Breathing Life into the New European Research Area and the ERA Policy Agenda Through Engaging Awareness-Raising Initiatives' (2021-2027).

assistant: **Innovation**

The goal of INSPIRING ERA is to leverage and accelerate the valorisation of results from the ERA Policy Agenda 2022-2024 through a service-oriented hub that connects and supports Member State, Associated Countries and Stakeholders with regard to their joint implementation of the ERA actions in close collaboration with the European Commission. The project aims to create and support a culture of mutual learning, to build and strengthen a viable community of practice for ERA that thrives through from insights, and to maximize the broad uptake of valorisation of results stemming from the ERA Policy Agenda actions through the elaboration of recommendation and guidance for policy-makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The safety and feasibility of retroviral mediated gene transfer in autologous stem cell transplantation for haematological malignancies' to be submitted under Fourth Framework.

assistant: **Abstract**

The haematological malignancies comprise the acute and chronic leukaemias, Hodgkin's disease and non-Hodgkin's lymphomas, and multiple myeloma. Many patients are curable with combination chemotherapy, but for those whose disease proves resistant to conventional approaches, the options are few and the outcome is poor. Novel treatment strategies such as gene therapy may improve disease free survival in the long-term but have yet to be proved both safe and effective. In the meantime, autologous stem cell transplantation [ASCT] has been widely used in an attempt to improve outcome. This approach permits the administration of high doses of therapy, as the patient can be rescued from the inevitable bone marrow failure by the reinfusion of cryopreserved autologous stem cells. However the use of ASCT has yet to be optimised. First, stem cells can be derived from the blood or bone marrow but there are qualitative differences between the two sources and the cells may therefore differ in their kinetics of recovery and their durability. Second, despite high dose therapy and stem cell rescue, many patients experience disease recurrence. The relapse may originate from contaminating tumour cells within the cryopreserved stem cells, or from tumour cells within the patients which survived the high dose therapy, or from both sources. This issue is of more than theoretical importance. If tumour cells persist in the transplant products then strenuous efforts should be made to remove them prior to infusion. If the relapse originates from residual tumour cells within the patient, then the emphasis must be on improved methods of tumour eradication. Studies in which unique genetic sequences are introduced into the tumour cells, so as to facilitate their detection later, are currently the only
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification of viral nuclear-homing proteins and their use for improved delivery of therapeutic genes using semi-synthetic vectors' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content. This project will develop efficient systems for targeted delivery of genes to cells,. It is an interdisciplinary project, combining my own expertise in cloning with expertise of my supervisors in viral infectivity and development of synthetic systems for gene delivery. The primary objective of the research project is to identify viral proteins capable of mediating nuclear delivery of DNA-containing nanoparticles for gene therapy. Individual objectives include: ? Identifying methods for efficient attachment of viral proteins onto DNA nanoparticles. ? Determine intracellular distributions of nanoparticles in cells by confocal microscopy ? Identification of viral proteins capable of promoting nuclear accumulation ? Evaluation of usefulness of these proteins in mediating transfection of cells in vitro. Training content (objective, benefit and expected impact) The Institute for Cancer Studies has a very good international reputation for gene therapy, and also in the study of viruses in oncology. There are few places in the world which combine these expertises. I expect to learn techniques of tissue culture, handling of DNA, reporter gene assays, microinjection and confocal analysis of intracellular distribution,. This should enable me afterwards to find good employment in this field, probably in Germany. Links with industry: The MRC Gene Therapy Programme has strong links with Glaxo/Wellcome, and Dr Seymour has increasingly strong links with Zeneca. (200 words not counting titles)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A two-photon compound fiberscope to study the brain at all spatial and temporal scales.' (2P-BRAINSCOPY), addressing dissemination and exploitation.

assistant: **Impact**

Understanding how neuronal circuits process information is a major scientific challenge, which demands new tools to address the complexity of the brain in animals during natural functioning. Two-photon (2P) microscopy, combined with optogenetics, has revolutionized neuroscience thanks to the possibility to image and photostimulate neuronal activity with light, but suffers from important limitations. To determine how perception and behaviour arise, we need to record and manipulate at will the activity of every neuron in a circuit in freely behaving animals. 2P microscopy is on the contrary mainly performed in head-fixed animals, which poses a clear limitation to the study of natural behaviour. At the same time, understanding how different brain areas exchange information requires to maintain single cell spatial resolution (~ 15 m) and temporal resolutions compatible with the propagation of neuronal signals (~ 1 ms) over ultra large spatial scales (5 mm), which is today completely out of reach for 2P microscopy. In this project I will overcome these limitations and develop the 2P compound fiberscope, a new optical technique based on the unique combination of multiple optical fibers and optimal spatial and temporal beam shaping approaches, which will completely change the way we study neuronal circuits thanks to two main technologies. 1) A flexible 2P micro-endoscope to image and photostimulate neurons in freely moving animals, which will give access to entire brain regions with the highest imaging and manipulation efficiency and the fastest acquisition speed. 2) The first 2P mesoscope specifically conceived to image and manipulate neuronal activity with single cell resolution across the majority of the mouse cortex on temporal scales compatible with the propagation of neu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A general theory of 'well-behaved' operational semantics', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The aim of this project is to formulate a mathematical theory of 'well behaved' operational semantics, complementing the established theory of domains and denotational semantics to form a coherent whole. The project is based on the categorical approach to operational semantics introduced in my thesis, which builds on G. Plotkin's (Edinburgh University) structural operational semantics - today's predominant approach to operational semantics and a fundamental tool for language design and verification. Training content (objective, benefit and expected impact) I will continue my extremely fruitful collaboration with Prof Gordon Plotkin , - one of the world's leading researchers in semantics - and his group, profiting from their exceptional experience m the field. I will also profit from / contacts with Prof Samson Abramsky's group. Links with industry / industrial relevance (22) This is a theoretical project, but, just like structural operational semantics is a fundamental tool for language design and verification, we expect this project will have a direct practical impact, eg, in modular compiler development technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A recombinant oral vaccine : an innovative solution for a total immunisation of fishes against furunculosis or goldfish ulcer disease' (1998-2002).

assistant: **Innovation**

Aquaculture has known since 25 years the fastest growth in the world food production. Aquaculture has to face a large variety of pathogens which needs to be understood and treated. A major disease affects trout (Furunculous) and ornamental fish (Goldfish ulcer). This disease can lead to death of the fish. This ulcerative disease is also known to affect many fish species of wild and farmed fish worldwide. The aim of this project is to examine the potential for utilising recombinant proteins as an antigen source for the total immunisation of fish by using an oral vaccine against furunculous or goldfish ulcer disease. Oral vaccination is very attractive since it is suitable for mass administration to fish of all sizes and in any culture system with no stress on the fish. It will overcome the many practical problems which currently restrict the use of vaccines in farmed fish. It will really improve the productivity. It will avoid the release of dangerous chemicals or antibiotics in the water. The suggested final product, in addition to being directed at a specific disease, is also the development of a technique for oral application of an antigen and could be evolved further for all forms of immunisation. Such a product is asset fish farms as wells for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Healthscaping Urban Europe: Bio-Power, Space and Society, 1200-1500' in the context of a Horizon 2020 call.

assistant: **Objectives**

Medieval public health is mired in modern myth: without centralized governments, democratic values and advanced medicine, promoting health at the population level was purportedly either unthinkable or simply impractical. Offering a radically different view, HealthScaping will document, analyze and disseminate knowledge about preventative public healthcare between 1200-1500, an era of accelerated urbanization followed by massive demographic decline, with the onset of Black Death (1347-51). This long-term and comparative perspective will fundamentally revise the narrative of European public health by tracing the development and impact of pertinent government policies, medical discourses and social and religious action in the continent’s two most urbanized and richly documented regions, Italy and the Low Countries. The project taps numerous written, material and visual sources and archaeological data from several sites, and examines them also by critically engaging the insights of governmentality studies, cultural-spatial analysis and actor-network theory. A multidisciplinary team, working in a Geographical Information Systems environment and generating innovative urban health maps, will recover earlier societies’ struggles with domestic and industrial waste, travel and labor hazards, food quality, and social and religious behaviors considered harmful or dangerous. As such, the project’s implications will be broad and profound, for it will 1) dislodge bio-power from its accustomed place in modernity; 2) historicize the concept of the public sphere from a health perspective; and 3) challenge the privileged role given to epidemic disease as a catalyst for environmental interventions in premodernity. It will also 4) generate new insights for public health scholars and practit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Bombs, Banks and Sanctions: A Sociology of the Transnational Legal Field of Nuclear Nonproliferation'.

assistant: **Concept**

As the critical sanctions against Iran’s nuclear program demonstrate, the implementation of sanctions (SANCT) against nuclear proliferators (PRO) has lead to the creation of a global system of surveillance of the financial dealings of all states, banks and individuals, fostered by the United Nations Security Council (UNSC) resolutions. This is a new and unprecedented development in transnational governance. This research will apply a sociological perspective to the study of this new “transnational legal order” by analyzing how new actors, institutions and legal technologies shape the processes of norm-creation and rules-implementation in the field of nuclear nonproliferation. PROSANCT asks: How have the social characteristics of the actors in charge of designing and implementing sanctions influenced the creation of new norms in the field of nonproliferation? Which legal technologies and which discursive practices have these new actors developed to impose their authority and their legitimacy on the regulation of global financial transactions? Answering these questions will generate a better understanding of key processes in global governance: 1) the increasing role of the UNSC as a global legislator through top-down processes of norms diffusion; 2) the “financialization” of global regulation, with the increasing role played by international financial institutions, which were historically foreign to the field of nuclear nonproliferation; and 3) the “judicialization” of the enforcement of sanctions, and the associated reconfiguration of relations between executive and judicial authorities in charge of punishing nuclear proliferators and sanctions-evaders at the domestic level. To study these legal processes in various contexts (the United States and Europe), PROSANCT appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'KOALALIFTER: WIND CRANELESS SYSTEMS', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

LEUNAMME has developed the KoalaLifter System, a disruptive lifting device that uses the Wind Turbine Generator (WTG) tower as a support, having an autonomous self-climbing capability. Therefore, there is no need for auxiliary cranes, making the system virtually independent of the tower height, weight to be lifted or wind speed limits. We have four international patents protecting KoalaLifter technology.Every year more than 18,000 new turbines are installed, and around 20,000 maintenance operations are carried out, which represents considering a small penetration of 6.9% (WTG maintenance) and 11.9% (WTG erecting) on 2025 a potential revenue for KoalaLifter of €86 million.KoalaLifter EIC Accelerator project aims to cover the gap between the current TRL6 level up to TRL9 stage. Main objectives are (i) to extent product range; (ii) to validate and certify products and processes; (iii) to prepare for commercialization; and (iv) to protect, exploit and communicate our solution. After raising funding from capital funds and bank loans, we are at the limit of our possibilities to raise quickly the additional €5.7 m to accelerate the finalization of our solution and be ready to commercialize it internationally in only two years; an EIC Accelerator blended funding will allow to achieve those goals.


**Keywords:** wind, turbine, green, energy, tower, erecting, maintenance, LCOE, efficiency, versatility, renewable, robot, mechatronics