RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modular devices for ultrahigh-throughput and small-volume nucleofection' (MODEST).

assistant: **Concept**

Modification of cells is a central topic in pharmaceutical and medical sciences as well as in basic research. Innumerable opportunities, e.g., in discovery of new regulatory pathways, novel targets, and potential drug candidates as well as clarification of signal transduction are addressed by cell transfection technology. The dominant consideration for cell manipulation is the type of cells used. Until now, most often conventional, immortal cell lines, being cultured for years or even decades in flasks, have been assigned to this specified use, although they are mainly irrelevant in physiological and medical respects. The optimal choice would be primary cells, since they are distinctly closer to the physiological situation than cell lines. Researchers would made rapid strides in the analysis of the biology of cells among others for the development of therapeutics, and new types of treatments as well as possible cures for a variety of diseases and injuries would be possible by using primary cells instead of cell lines. However, primary cells until recently were hard or often even impossible to transfect by non-viral methods, and consequently, many researchers still hesitate to adopt these cells despite their unquestionable advantages. With the advent of the nucleofection technology, a unique method for the highly efficient transfection of primary cells was recently made available to the life science community.With MODEST the main objectives are i) the development of devices for ultrahigh-throughput nucleofection of primary cells in modular multi-well plates, and ii) the application of this technology to the highly relevant area of immunological as well as neuronal disorders to facilitate investigations of possible mechanisms of intervention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a bioreactor-based connective tissue production line (TISSUE REACTOR)' (1998-2002).

assistant: **Concept**

It is the aim of this project to engineer connective tissue in vitro and to demonstrate its applicability as a tissue substitute in vivo. To achieve this goal a continuous cultivation process based on a perfused fixed-bed bioreactor system and its components will be developed which allows the production of large quantities of three-dimensional (3-d) tissue cultures in combination with capillary-like prevascular precursors to form in vitro tissue constructs. The primary focus will be bone tissue, and bone tissue constructs will then subsequently be implanted in vivo to demonstrate their potential to improve current limitations in bone substitution surgery.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optimizing Policies for Transport: accounting for Industrial Organisation in Network markets', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Traditional models of transport networks ignore the existence and strategic behaviour of large actors who are often active in transport markets. Examples of such large actors are private infrastructure or service operators, insurance companies, or vehicle manufacturers. Both for positive and normative analyses, this omission can lead to substantial errors, and therefore to seriously biased policy evaluations and recommendations. The reason is that such actors will have their own objectives to pursue, while their market power gives them ample opportunity to influence market outcomes through strategic behaviour. Ignoring their behavioural responses to policy changes therefore leads to a wrong prediction of the policy s optimal design as well as its impacts. An important reason why they are nevertheless usually ignored is the analytical and numerical complexity of transport network models in which large actors, with strategic behaviour, are active. This project seeks to develop such models. Specific applications will include models of road transport networks allowing for private road operators, vehicle manufacturers, and insurance companies; models of urban taxi markets; and networks models for public transport and aviation. Although applying to different cases, these models will have important methodological characteristics in common, particularly in that they apply multilevel optimization techniques for (transport) network models that account for strategic behaviour of and interactions between large actors. We will investigate how this behaviour affects the formation of network equilibria in transport markets, as well as the impacts and (second-best) optimal design of transport policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fiscal Rules and Strategies under Externalities and Uncertainties' in the context of a Horizon 2020 call.

assistant: **Objectives**

The FIRSTRUN project advances the theoretical and practical debates on the effective mechanisms of fiscal policy coordination. It analyzes the very reason why fiscal policy coordination may be needed in the first place, namely cross-country externalities (spillovers) related to national fiscal policies. Specifically, it identifies different types of spillover effects, investigates how they work in the EU and in the EMU, and analyses whether they work in the same fashion under different states of the economy and over the short and the long run. The project describes different forms that fiscal policy coordination can take in practice, e.g. ex-ante coordination and risk-sharing, and provides a critical assessment of the mechanisms already put in place. The FIRSTRUN project provides new tools for fiscal policy design by incorporating the new EU fiscal rules regarding e.g. government debt and deficit into applied models for fiscal policy evaluation. The tools can be used to support the decision makers in the implementation of the enhanced EU economic governance. FIRSTRUN also investigates the political economy of fiscal cooperation, for instance, the difficult inter-play between domestic political pressures and EU level priorities as well concerns about legitimation. By shedding light on the character of the governance framework for fiscal coordination, FIRSTRUN will highlight the features that work well or badly and provide insights that the EU level can exploit in its surveillance and advisory roles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced Solution for Smart Telemetry Machine-To-Machine applications' under Horizon 2020.

assistant: **Concept**

NEW ARYEL will launch in the market an advanced and cost-effective Machine-To-Machine (M2M) solution in the smart telemetry applications market.NEW ARYEL is innovative compared to the current state of the art because, unlike any other M2M solution, it integrates several advanced M2M functionalities into the same device with clear economic and technical advantages for clients.Telemetry is a flourishing market estimated to reach global $103 Billion by 2019 with M2M connections expected to reach 33.2 Million worldwide in 2017.NEW ARYEL is a smart telemetry device, built by Alosys and based on technology already patented by the company, conforming to international ISO standards and EU regulations. It is adaptable to communicate and connect with many different apparatuses, with the capability of real-time, multichannel transmission and unique technical characteristics such as multiple I/O ports, communication channels and open source software currently not available in the market.NEW ARYEL will provide clients with economic and environmental benefits saving energy, cutting maintenance and downtime. It has already been tested with Alosys clients such as Telecom Italia and Poste Italiane who are also interested to be early adopters.Target users will be large industries and public/private organisations which need reduce costs and generate revenue through new services. These needs are still unmet by existing solutions. Thanks to the SME Instrumet Phase 1 Alosys will conduct a feasibility study to deliver a business plan to support Alosys in successful market introduction of NEW ARYEL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Local Government and the Changing Urban-Rural Interplay' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

LoGov aims to form an international and intersectoral training and research network in order to provide best-fit practices for local governments to address the changing urban-rural interplay and manage its impacts. As a global Consortium composed of eight European and nine non-European partners, we seek to (1) to identify, evaluate, compare and share practices in five major local government areas (local responsibilities, local finances, local government structure, intergovernmental relations and peoples participation); (2) to encourage the effective application of the best-fit practices by local governments; (3) to strengthen international and intersectoral collaborative research; (4) to enhance the career perspectives of the staff involved by increasing their mobility both within the academic and the non-academic sectors and between these sectors.LoGovs methodological approach relies on a comprehensive comparative analysis that draws on findings from 15 countries or wider regions on six continents, the extensive involvement of local policy-makers through local government associations and a multi- and interdisciplinary approach that is facilitated by the Consortiums expertise in four disciplines (public law, political science, public administration and economics).The training strategy of LoGov is based on both secondment-related and network-wide activities. The strategy combines well-established events with newly developed transferable and research skills training, including open science, communication and research transfer training.To achieve the maximum impact, LoGovs dissemination strategy targets both the wider scientific community and local policy-makers. It does so when sharing the key training result of widening career perspectives and the main research result of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High-throughput production platform for the manufacture of light emitting components' (LIGHT-ROLLS).

assistant: **Innovation**

Light-Rolls focus on research and development of modular based production units for the seamless, high throughput manufacture of micro-structured, polymer based components and Microsystems. The scientific objective aims to realize structures in the micron range and integrate also Dies, smaller then 0,5mmx0,5mm and thickness down to 50 um to be assembled in high-speed. Nanopar-ticulate dispersions used in fast conductive track printing technologies will allow the parallel gen-eration of conductive lines down to 30µm track width.   Light-Rolls is based on highly innovative manufacturing and assembly technologies: 1. RMPD®-rotation, a patented process technology, which uses a UV curable liquid to generate polymer structures (generative manufacturing approach). 2. New chip assembly methods, originating from self assembly methods 3. High resolution – high speed conductive track and interconnection generation by ink-jet printing methodologies.   These processes comprise the founding elements of the Light-Rolls technology platform with a roll-to-roll philosophy. The manufacturing modules will be integrable, exchangeable, with mechanical, fluidic and IT interfaces, to make it easy and cost efficient to adjust the sequence of process steps to the product to be produced. Besides the translation of processes for high-throughput manufacturing, high yield will be achieved by the application of advanced process control and production IT meth-ods. Lines run without dangerous chemicals and use integrated recycling. For future products a Light-Rolls knowledge base for design for manufacturing will be elaborated. A pilot line will be set-up, tested for fabrication of flexible LED-display systems. Manufacture of other components like Lab-on-Chip or integration of new micro-energy storage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Advance Marine Research Infrastructures Together'.

assistant: **Concept**

The European Ocean Observing System (EOOS) is the foundation of European ocean knowledge. The core Marine Research Infrastructures (MRIs) focused on ocean observing (EMSO, EURO-ARGO and ICOS ERICs; EuroFleets+, EuroGoShip, GROOM RI, JERICO RI and MINKE as INFRA projects) are the main providers of in situ ocean data for the EOOS and Copernicus, and the primary managers of instrumental capacity supporting fundamental research.These MRIs are aware that the lack of effective cross coordination prevents them from fully supporting frontier research, while the lack of integration makes it difficult to reach a critical mass for EOOS and results in significant cost duplication. Accordingly, AMRIT gathers these MRIs together with OceanOPS/WMO international coordination experience with the objective to:- ensure seamless operation of marine observation platforms ;- ensure the full nominal use of sensors and accelerate their evolution ;- exploit the complementarity of the various observation platforms ;- ensure the overall coherence of the ocean data value chain.To achieve these objectives, AMRIT will design and implement an EOOS Technical Support Center (EOOS TSC) for- a fully integrated information service across the data value chain from early planning stages to final delivery to users;- a cross-platform fully standardised data acquisition methodology for Essential Ocean Variables;- a collaborative federal structure to operate these services, relying on the ERIs and their members.The EOOS TSC will be the cornerstone in establishing and maintaining the EOOS, upon which European ocean observing can be strengthened in the coming decades. AMRIT will provide a catalyst for the development and consolidation of MRIs throughout Europe, providing a benchmark for operational coordination a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mediteranean development of innovative technologies for intergated water management' (MEDITATE) targeting Sixth Framework.

assistant: **Abstract**

MEDITATE aims at the development of a water management support system at the Mediterranean catchment level, integrating the use of alternative water resources such as karst submarine springs, seawater or brackish water desalination and water reuse, for wa ter scarcity management. Innovative technologies for submarine springs, from survey using an autonomous underwater vehicle, monitoring at the spring level till capture prototype, will be developed mainly in this project. Economical and environmental study of submarine springs will be conducted and taken into consideration.Submarine springs study will also be used to determine the real water resource potential at the coastal karst aquifers in three Mediterranean catchments. The submarine springs could repres ent important alternative water resource as it has been reported during the last 30 years, but without serious scientific arguments. New technology for characterising the submarine springs will help to infirm or confirm this hypothesis. Low cost and low energy desalination plants for temporary use and salinity variability of submarine springs water will not be developed within MEDITATE, but designed based on feasibility analysis. A general analysis of desalination cost for various conditions will be taken into account in the socio-economic analysis for the management system. In the same manner, a review of water reuse will be carried out, taking into consideration environmental and health problems, technical and cost problems in order to have serious data to be considered in water management scenarios. The water management support system will bring stakeholders in a decision making process considering water visions for 2025. The WMSS will provide set of scenarios, giving safe water yield, based on the cha racterisat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Magnetic sensing by molecules, birds, and devices' (ChemNav) targeting Seventh Framework.

assistant: **Abstract**

The sensory mechanisms that allow birds to perceive the direction of the Earth’s magnetic field for the purpose of navigation are only now beginning to be understood. One of the two leading hypotheses is founded on magnetically sensitive photochemical reactions in the retina. It is thought that transient photo-induced radical pairs in cryptochrome, a blue-light photoreceptor protein, act as the primary magnetic sensor. Experimental and theoretical support for this mechanism has been accumulating over the last few years, qualifying chemical magnetoreception for a place in the emerging field of Quantum Biology.In this proposal, we aim to determine the detailed principles of efficient chemical sensing of weak magnetic fields, to elucidate the biophysics of animal compass magnetoreception, and to explore the possibilities of magnetic sensing technologies inspired by the coherent dynamics of entangled electron spins in cryptochrome-based radical pairs.We will:(a)  Establish the fundamental structural, kinetic, dynamic and magnetic properties that allow efficient chemical sensing of Earth-strength magnetic fields in cryptochromes.(b)  Devise new, sensitive forms of optical spectroscopy for this purpose.(c)  Design, construct and iteratively refine non-natural proteins (maquettes) as versatile model systems for testing and optimising molecular magnetoreceptors.(d)  Characterise the spin dynamics and magnetic sensitivity of maquette magnetoreceptors using specialised magnetic resonance and optical spectroscopic techniques.(e)  Develop efficient and accurate methods for simulating the coherent spin dynamics of realistic radical pairs in order to interpret experimental data, guide the implementation of new experiments, test concepts of magnetoreceptor function, and guide the desi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cellular composition of the pancreas: elucidating the role of mesenchymal signaling pathways', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The pancreas constitutes of various cell types with distinctive function.  Exocrine cells produce and secrete digestive enzymes while endocrine cells, including insulin-producing beta-cells, secrete hormones that regulate glucose homeostasis.  The proportional quantity of the different pancreatic cell populations is well defined, when exocrine cells encompass majority of the tissue mass.  However, while the establishment of pancreas cellular composition during embryogenesis has been well acknowledged, its regulation is far from being elucidated.  While cell intrinsic cues were shown to influent this process in the developing pancreas, the role of extrinsic signals is less understood.  I hypothesize that extrinsic cues define the rate of cell proliferation and therefore govern the sizes of various pancreatic cell populations in vivo.  Here I will use a novel transgenic mouse model I have recently developed, the Nkx3.2-Cre mouse line, as a tool to evaluate extrinsic roles in the regulation of pancreas cellular composition.  I will further use this tool to elucidate the extrinsic cues playing a role in this process.  To this end, I will deregulate signaling pathways in the pancreatic mesenchyme, a key component of the embryonic pancreas microenvironment.  I will focus on two such pathways, the Hedgehog and the Wnt pathways, which are required for normal mesenchymal gene expression.  I expect their deregulation will hamper mesenchymal ability to promote appropriate pancreatic cellular composition, and will enable the identification of extrinsic cues required for this process.  The findings of this study will allow better understanding of the extrinsic requirements during pancreas development, and the cues governing its cellular composition.  Furthermore, this study will aid