RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The EU, China and South East Asia Dialog for the development of research areas in animal health of mutual interest' in the context of a Sixth Framework call.

assistant: **Objectives**

Trans-boundary diseases have the potential for very rapid spread irrespective of national borders, causing serious socio-economic and possibly public health consequences.  The past decade has been characterized by several outbreaks of animal diseases (such a s FMD, Rinderpest, CSV) with a huge challenge to food security, food safety and animal welfare. In addition, a number of zoonosis occurred and occur around the world, such as Avian influenza, SARS, Ebola and mad cow disease.  All of them share the main feature of being diseases common to human and other animal species, domesticated or wild.  The objective of the project is to identify areas of mutual interest for future collaborations between the EU, China and South-East Asia regarding animal health and food chain safety, by  a) organizing a bi-regional dialogue between Europe and Asia to determine areas of mutual interest in animal health, food safety and traceability;  b) building expert working groups to identify research and action priority to be addressed within the FP7.  The workshops will be organised by an international committee consisting of two European partners and three scientists from the Asian partner countries.  The workshops will create an enabling environment for a frank and open debate on prevailing animal health issues of relevance to both the EU and Asia and will have this structure:  - Plenary sections addressing key cross-cutting issues such as the interrelations between economic development, trade and culture in food production, processing and consumption.  - Oral presentations by key speakers from Asia and the EU, focused on specific target diseases and their implications for public health.  Working groups on scientific and technological requirements to provide innovative solutions to zoonot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Novel Drug research to Address Microbial infections and drug Resistance' under Horizon Europe.

assistant: **Concept**

Antimicrobial-resistant and persistent bacterial infections represent major global healthcare challenges, imposing substantial costs and highlighting the urgent need for new and more effective treatment options. The World Health Organization and other international bodies have identified critical gaps in the current antibacterial drug discovery pipeline, which relies heavily on similar mechanisms of action and fails to address the needs of low- and middle-income countries. The rapid emergence of bacterial resistance, coupled with a lack of globally applicable therapeutics, continues to exacerbate the antimicrobial resistance (AMR) crisis.The European Novel Drug Research to Address Microbial Infections and Drug Resistance (END2AMR) consortium aims to tackle these challenges by developing innovative therapeutic modalities and delivery technologies that can overcome current treatment limitations. END2AMR brings together a multidisciplinary public–private partnership comprising pharmaceutical, biotechnology, and academic expertise to advance a diverse portfolio of novel antibacterial modalities and delivery technologies. These will be applied independently or in combination to improve patient outcomes, using specific bacterial pathogen case studies as a basis for broader translational impact. The case studies targeting specific bacterial pathogens will serve as exemplars to extend these approaches to other infectious diseases.Main Objectives:• Advance and validate innovative strategies to treat chronic and drug-resistant bacterial infections, with particular emphasis on Gram-negative bacteria and mycobacteria.• Develop a versatile toolkit to enable the creation, optimization, and translation of next-generation antibacterial treatments.Key Deliverables:• Demonstrate proof of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nutrition and reproductive strategies: the influence of dietary antioxidants on telomere dynamics and life history plasticity in birds' (EVOTELOX) under Seventh Framework.

assistant: **Objectives**

EVOTELOX seeks to examine the extent to which environmentally driven variations in early life nutrition influences oxidative status and telomere loss in vivo, and thereby the costs and benefits of different life history trajectories. Despite the promising role of telomere biology in understanding the biology of life spam, currently little is known about factor that affect telomere dynamics in natural systems and whether telomere dynamics during early life may constraint life history traits. The main objectives of this project are to (1) examine the effect of dietary antioxidants on oxidative status and telomere loss of Zebra finches during their early development and (2) investigate the effect of early life nutrition and telomere dynamics on sexual maturation and reproduction during adulthood. We will use a multidisciplinary approach, combining ‘state of the art’ techniques in evolutionary biology, gerontology and ecophysiology to quantify telomere length and the level of oxidative stress in addition to manipulative experiments. The ultimate aim of this study is establishing sustainable collaboration between the host institute and fellow for the future researches in the fellow’s country of origin. We will continue cooperation to obtain advanced expertise on model systems and physiology of life history trade-offs.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Origin and determination of the peripheral nervous system in the ascidian, Ciona intestinalis: role of the Notch signalling pathway and the cell cycle control mechanisms'.

assistant: **Concept**

A tight co-ordination between cell proliferation and differentiation is essential to the correct development of all multi-cellular organisms. The intercellular signalling pathway triggered by the receptor Notch is central in maintaining the co-ordination between cell cycle control and neuronal cell fate acquisition during vertebrate development. However, the mechanistic details of its action are still ill understood. This is largely due to the great anatomical and genetic complexity of the available vertebrate model systems. The ascidian, Ciona intestinalis is a basal chordate.It is phylogenetically close to vertebrates, but morphologically and genetically very simple and well characterized. We propose to exploit the simple peripheral nervous system of Ciona intestinalis to study the interactions between Notch signalling and the cell cycle control mechanisms in chordates. Our project aims first at understanding the respective contributions of the Notch pathway and the cell cycle control machinery in defining the number of peripheral nervous system neurons in Ciona larvae.In a second time, we will explore the connections between the two mechanisms. To this end, we will take advantage of the amenability of Ciona embryos to a large spectrum of developmental and molecular biology manipulations. The project will result in a better comprehension of the mechanisms, which regulate cell proliferation and differentiation in chordates. This may in turn lead to the identification of new genes involved in human proliferative disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Functional life prediction of elastomeric components'.

assistant: **Objectives**

To maintain the competitiveness of supplier and end-user industries of components made from rubber, greater knowledge of processing, design and service environment factors on functional life is needed. To solve this problem the objectives are:(a) identify and quantify key factors in processing, design and service environment that control the functional life of rubber components, and(b) develop computer simulation models that can be used to rapidly predict the performance of improved processes or designs.The objectives will be achieved by:(1) investigation of mixing and moulding factors on functional life,(2) modelling components behaviour in service, (3) development of materials tests and performances models, (4) validation of computer simulation models with component test and end-user trials.The expected results are:(i) validated predictive models that simulate component performance in automotive break systems,(ii) know-how and predictive models to optimise processing and design, assess alternative materials, define accelerated test conditions, reduce prototype testing, reduce development time, and improve reliability.Laboratory test methods and procedures:For materials evaluation, test methods and procedures were developed for hyperelastic, viscoelastic and fatigue properties for elastomers accounting for thermal and other service related effects. Rheological test procedures were developed for uncured material. A test to quantify the strength of weak rubber-rubber interfaces and assess factors affecting weak interfaces was developed. A gas decompression test was developed to diagnose the presence of weak interfaces in manufactured components. For component evaluation an accelerated durability test was developed for brake booster diaphragms.Material models:Material mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Constraint solving and language processing for bioinformatics'.

assistant: **Innovation**

The objective of the proposal is to bring the host institution together with the Chair and various collaborating European research teams in France, Denmark, Lisbon, and with Canada, to build on the success of their recent results in hypothetical reasoning, language processing and constraint based reasoning. The goal will be to obtain enhanced solutions of interdisciplinary tasks in the intersection of computational linguistics, logic programming, molecular biology and other bioinformatics applications. These objectives will be achieved by integrating and enhancing our proven results in collaboration with the host institution, further applying them to the proposed themes, and training high quality postgraduate students in this promising emerging field, as well as disseminating the results widely in publications, a book and through specialized and general talks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Climate-resilient management for safe disinfected and non-disinfected water supply systems'.

assistant: **Objectives**

Safe and affordable supply of drinking water (DW) in the EU under the pressure of climate change is a key priority. Despite long-term experience with the reliable operation of disinfected and non-disinfected drinking water supply systems (DWSS), a number of challenges around microbial stability, the (future) need for disinfection and the consequences of disinfection by-products (DBPs) formation for human health remain open, directly deriving from climate change impacts such as increasing water temperature and higher levels of natural organic matter (NOM).SafeCREW aims to support the novel EU DW Directive by generating advanced knowledge and developing tools and guidelines for disinfected and non-disinfected DWSS and addresses improved comprehensive water quality characterization, novel treatment solutions to actively respond to identified threats, and the management of distribution networks to avoid water quality deterioration up to consumers.Novel data sets on the occurrence and concentration of so far unknown DBPs will be created, and commercial actors stimulated to further develop tools for DBP quantification and mitigation.Transferable tools will be provided to end-users (water utilities, national/EU regulators, researchers, SMEs), including: (I) reliable methods to evaluate microbial stability, characterise NOM, detect DBPs and account for DBP human health toxicity, (II) protocols to select proper materials in contact with disinfected water, (III) monitoring and modelling tools, also exploiting machine learning, for real-time optimisation of DWSS management, and (IV) an integrated risk assessment framework to guide future interventions which ensure that both disinfected and non-disinfected DWSS can continue providing safe DW in the face of climate change.SafeCREW w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification and analysis of candidate genes involved in key steps of gametophytic apomixis' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Apomixis is a fascinating developmental process with a tremendous potential for plant breeding. Sexual reproduction and apomixis are closely interrelated and often occur within the same plant species. At least three key developmental steps are altered in a pomictic plants: (i) meiotic reduction is omitted or altered (apomeiosis), (ii) embryogenesis is initiated autonomously (parthenogenesis), and (iii) functional endosperm is formed through developmental adaptations. The molecular basis of (a) sexual reproduction is largely unknown.The goal of this project is to identify genes expressed in key steps of apomictic development in Boechera gunnisoniana, a close relative of Arabidopsis. I will establish methods for heterologous transcriptome analysis (Boechera RNA on Arabidopsis GeneCHIPs), determine the transcriptome of the cell giving rise to an embryo sac and of the egg cell in apomictic reproduction of Boechera, and identify genes of putative importance for apomixis by comparing Boechera and Arabidopsis transcr iptomes (the latter obtained in projects ongoing in the Grossniklaus lab). I will further investigate the in planta roles of candidate genes for reproduction.This project will significantly contribute to our understanding of the molecular basis underlying (a) sexual reproduction. The results are expected to cover one scientific paper on the comparative transcriptome analysis and one on the analysis of candidate genes. The proposed research on the cutting-edge topic of plant reproduction will be performed in an internationally acclaimed laboratory. My training objectives are to enhance my scientific knowledge on the topic, to gain experience in new state-of-art technologies, like laser capture micro-dissection and transcriptomics, and to enhance my research experie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Environmental Histories of Resource Extraction in Africa: Understanding Cultural and Political Responses to Environmental Transformation' (AFREXTRACT) under Horizon Europe.

assistant: **Objectives**

Resource extraction industries have propelled environmental transformation across Africa, most notably between 1950 and 2020. The undeniably dramatic effects of mining and oil drilling on landscapes and lifeworlds have elicited radically divergent cultural and political responses, from apparent acquiescence to violent protest and accusations of ecocide. Yet the nature of the relationship between environmental change and human response in African localities remains extremely poorly conceptualised. AFREXTRACT addresses this gap by analysing how various actors in three emblematic sites - the Witwatersrand, the Copperbelt and the Niger Delta - have experienced and responded to environmental change. The first study to investigate this comprehensively and comparatively, AFREXTRACT demonstrates that insights from environmental history, political ecology and environmental humanities are crucial to topical debates about coloniality/decoloniality and the Anthropocene. Our main objectives are: 1) to identify the causal factors informing human response to environmental transformation through three in-depth case studies (gold mining in South Africa; copper mining in Zambia; oil drilling in Nigeria); 2) to analyse how cultural expression (specifically literature and music) has made sense of environmental change; 3) to conceptualise varieties of environmentalism beyond a binary of resistance and resignation. AFREXTRACT will combine archival research with oral history, literary analysis and ethnomusicology to document changing values regarding the environment. A new analytical framework will facilitate engagement with global discussions about extractivism, colonialism/postcolonialism, environmental inequality and climate change. As resource extraction and its toxic legacies are set to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'On the development of novel molecular and microscopy methodologies for the interrogation of host-pathogen interactions at the single-cell level' to be submitted under Horizon 2020.

assistant: **Abstract**

Over the course of host-pathogen evolution, both the players in this game have set out strategies to overcome each other, by adapting to challenging environments and camouflaging on the one side, and by detecting and eradicating the enemy on the other. In this context, the identification of the pathogenic potential, that is, the genetic elements conferring virulence and how they subvert the host’s defences, is fundamental. With a multiplexed approach, I aim at developing a pooled genetic screen using CRISPR interference to produce pathogen knocked-down libraries impaired in a curated subset of virulence factors of Salmonella Typhi. This pathogen is of particular interest because of the severity of its systemic infection combined with its human host-restriction, which left research lagging behind. Several cellular systems (macrophages, PBMCs, organoids) will be probed upon infection of S. typhi mutants, and the host transcriptome retrieved by single-cell RNA-seq. This analysis will provide a systematic and thorough map of the cause and effect network of the pathogen virulence factors and host responses.Interestingly, in this pathogen-host “war”, each battle can end with a different winner, even when the teams are comprised of the same players, meaning that the heterogeneity in the cellular state of both the pathogen and the host previous to the infection, can lead to the occurrence of diverse outcomes within a single population. The pathogen can either replicate, persist or be cleared by the host. This intrinsic cell-to-cell variability posits the importance of profiling simultaneously the host and the pathogen at the level of single cells. To achieve this goal, I will profile the transcriptomes of the host and the pathogen at the same time, by using multiplexed smFISH.