RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A comparative clinical study of a stool-based versus a blood-based screening test for early detection of CRC' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer deaths in Europe and USA. Its incidence and difficult early-diagnosis make CRC a primary focus in the oncology community. Although colonoscopy is currently the most reliable clinical tool for precise detection of CRC, the invasive nature and the incurred cost have hampered the wide application of this procedure. On the other hand, the fecal occult blood test (FOBT) and the fecal immunoistochemical test (FIT) are non-invasive screening tests that can be used prior to colonoscopy. However, they both lack the sensitivity or specificity required for an effective screening tool and they require meticulous dietary restriction, overall not reaching the full compliance of the general population. Thus, there is a pressing need to identify specific non-invasive biomarkers for early diagnosis of CRC. Within the frame of the ERC starting grant OxyMO, we investigated the diagnostic potential of blood derived circulating monocytes for colorectal cancer (CRC). Our transcriptome characterization revealed a CRC-specific gene signature that was further developed as the ‘Monomark‘ diagnostic test (patent WO2013/110817), which showed a strong diagnostic power for CRC detection. This signature was triggered by signals specifically released by CRC cells regardless of their stromal niche (primary tumor vs. metastatic site) or oxygen tension. In this prospective study, we will compare the strength of the Monomark signature towards the FIT test in patients with a positive stool test. Therefore, in parallel to the routine FIT screening, blood samples will be harvested and the monocyte genetic profile will be determined. This fundamental study, will disclose the diagnostic power of our biomark
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enlargement Network for Agripolicy Analysis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

AgriPolicy builds on the results of the previous FP6 project “CEEC AGRI POLICY” (www.agripolicy.net) which was awarded financial support by DG Research in 2004 following the call FP6-2003-SSP-3. The overall objective of the proposal is to support the formulation of Community agricultural policies.   AgriPolicy has 4 specific objectives:  1. Networking and information sharing The objective is to stimulate the networking and the sharing of information between organisations involved in agri-economics analysis. The networking will be stimulated through the organisation of 3 symposia and 6 workshops and the development of a dynamic web site including an up-dated directories of experts and organisations.  2. Provide scientific input for policy making The objective is to provide analyses on a number of specific topics (8-monthly as well as “report on demand”).   3. Prepare future analysis  The objective is to prepare for future policy and sectoral analyses and research by collecting quantitative and qualitative information. In the NMS, 3 monitoring reports of agricultural and rural will be prepared. In the WBC, a study on the existing availability of  key agricultural and rural statistics will be prepared.  4. Develop analytical capacities  The objective is to strengthen the analytical capabilities of the research organisations involved in the project in the field of policy evaluation and foresight analysis. This will be achieved by implementing training sessions as well as conducting pilot studies.   AgriPolicy will be implemented by a team of experts from 24 organisations from 24 countries. The team is composed of the partners of the former project, augmented with new competencies from the “old Member States » (IAMO in Germany and LEI in the Netherlands), from Malta and from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SunOyster cooling' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Increasing demand for air conditioning with worldwide more than 100 million units of compression air conditioners sold alonein 2014 has led to dramatic growth in electricity demand in many countries, to increasing electricity costs and brownouts. Anobvious possibility to counter this trend is to us the same energy for cooling that contributes to the cooling demand – solarenergy.The objective of the SOcool Project is to use a concentrating photovoltaic/thermal (CPVT) system combined with chillers toprovide the most cost-efficient solar energy on the market in form of electricity, heat and cold. This shall help achieving the2K target while enhancing the living standard in rather hot climates.The SunOyster is a concentrating solar technology which can generate at the same time electricity and heat with a very highefficiency. From serial production, this will result in very low electricity and heat costs. While the electricity can easily beconverted into other forms of energy and can be fed into the grid, the heat is more difficult to convert and has to be usedlocally. A technically, micro-economically and macro-economically very good form of using the heat in hot climates isconverting it into cold for the cooling of buildings.The biggest markets will be Southern Europe (Spain, Southern France, Italy, Greece, Turkey), Northern and Southern Africa,the Gulf region, India, South-East Asia, parts of China, Southern USA, parts of Middle and South America.After entering the market in 2017 with big quantities, we expect growth rates of factor 3 respectively 2 and 1.5 in thefollowing years until 2020 then settle down on growth rates of 10% to 20% in the next decade.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ovarian Cancer Therapy – Innovative Models Prolong Survival' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

About 75% of advanced epithelial ovarian cancer (EOC) patients respond to first-line surgery and chemotherapy but most relapse and ultimately acquire platinum resistance which soon leads to death. Relapsed high grade serous ovarian cancer (HGSOC) is the single main cause of EOC-related morbidity and mortality (despite the fact that HGSOC is highly chemosensitive). We hypothesize that the primary tumour includes a small population of resistant cells that are ultimately responsible for relapse and that by targeting this population front-line we may prolong disease-free survival or even achieve cure. OCTIPS will use unique retrospective and novel prospective paired tumour samples collected at the time of diagnosis and relapse to identify and validate molecules and pathways responsible for relapse. This identification will employ cutting edge high throughput multiplatform analyses such as next generation sequencing, mRNA and miRNA  expression arrays and SNP array. Known and newly defined molecules or pathways will be evaluated in innovative integrated cancer model systems, utilising cell lines and avian egg and murine xenografts. New therapies to target these molecules and pathways will be developed and validated in these model systems. In order to translate these findings into patient benefit, agents that target the relapsing cell population will be tested for tolerability, efficacy, ability to combine with first line chemotherapy and then in randomised first line trials by the OCTIPS consortium.By translating the clinical observation of treatment failures into innovative cancer models that mimic relapsed ovarian cancer, we will validate improved front-line therapeutic strategies to help prolong patient survival. The impact of this application is that it defines a highly r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated biomolecular methods to control mosquito-borne diseases' (MOSQUITOBLOCK).

assistant: **Innovation**

Mosquitoes transmit some of the world's most serious diseases. The most important disease vectors are members of the subfamilies Anophelinae and Culicinae. Anopheles mosquitoes transmit malaria, filarial parasites , and a few arboviruses. There are 30 genera in the Culicidae subfamily, but the medically important mosquitoes are Culex, Aedes, Mansonia, and Annigeres (Culex would be important in Europe for West Nile Disease and Avian malaria), while (Aedes would be more important in Tropical countries). Over the last 45 years, the use of chemical pesticides such as dichlorodiphe-nyltrichloroethane (DDT), gammaxane, malathion, and chlordane has been the method of choice for mosquito control, and the antimalarial drugs chloroquine and the affordable pyrimethamine-sulfadoxine combination have proved successful in lowering morbidity and mortality. In addition, the emergence of pesticide and drug resistant mosquitoes, coupled with a clearer appreciation of the long-term detrimental effects of powerful chemicals to non pest insects and concern about accumulation of pesticides in the food chain and environment, has high lighted the need to quickly develop an alternative. A promising alternative is biological control. So, this project would focus on non-chemical methods of control mosquitoes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Early pregnancy ultrasound and biochemical markers of pre-eclampsia and growth restriction' (2002-2006).

assistant: **Innovation**

Pre-eclampsia (PE) complicates 8-10% of pregnancies and represents one of the leading causes of maternal mortality and morbidity. PE is also a major cause of fetal mortality and morbidity, particularly as a result of placental abruption, intra-uterine growth restriction (IUGR) and premature delivery. At present, no early and reliable screening test for PE or IUGR is available. The main objective of this project is to investigate the possibility of combining multiple early pregnancy ultrasound and biochemical markers in order to identify pregnancies at high risk of subsequently developing PE or IUGR. This will involve the assessment of uterine artery flow by Doppler ultrasound, and the determination of multiple maternal serum and urinary markers, in order to identify the best combination of markers to include in a multivariate screening model. The investigations will be repeated at two different gestational intervals in the same unselected pregnant population: 10-14 weeks and 15-18 weeks of gestation. The inno vative approach of the present project is mainly represented by: a) combining uterine artery assessment and a panel of maternal serum and urine markers. This approach has proved to be extremely successful in screening for other conditions in pregnancy.  b) assessing the screening value of these markers at two gestational intervals in early pregnancy (10-14 weeks and 15-18 weeks), at which stage preventive measures to modify the natural history of the condition are likely to be effective, as opposed to screening tests performed later in pregnancy (from 20 weeks onwards). If successful, the project would therefore be able to provide a reliable early screening tool, and open the way to a series of interventional trials to evaluate the efficacy of the preventive strate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Low Degree Points on Modular Curves' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The study of Galois representations of elliptic curves is at the heart of modern arithmetic geometry, and intimately related to modularity theorems and the proof of Fermat's Last Theorem. Galois representations of elliptic curves are classified by their images. Associated to a possible image is a modular curve which is a moduli space of elliptic curves with representation having that image. The study of rational and low degree points on modular curves underlies the celebrated theorems of Mazur, Kamienny, Merel, Bilu, Parent and Rebolledo. A common theme in all these works is the existence of a rank zero quotient of the modular Jacobian, and the validity of a formal immersion criterion. In this project, motivated by Serre's uniformity conjecture, we study rational and low degree points on interesting modular curves where these conditions fail, developing and extending powerful methods including an overdetermined version of Chabauty in the symmetric power setting, and quadratic Chabauty for the non-split Cartan modular curves.The University of Warwick has a strong and active number theory group, making it a natural host for the project. The Supervisor, Professor Siksek, is a leading expert on curves, Galois representations and modularity, with considerable experience in supervising research including 11 postdocs and 12 completed PhD students. The Researcher, Dr Le Fourn, did his PhD at Bordeaux (completed November 2015) with Professor Pierre Parent, including a 3 months internship at McGill with Professor Henri Darmon. Since September 2014 he has held the position of Agrégé préparateur at the École Normale Supérieure de Lyon. He has made excellent breakthroughs both in the theory of Q-curves, and in the arithmetic of Siegel modular varieties. The envisioned research will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Leaf-inspired nanocellulose frameworks for next generation photosynthetic cell factories' (FuturoLEAF).

assistant: **Concept**

FuturoLEAF envisions to exploit know-how in nanocellulose materials and cell biology to revolutionize the field of industrial algal biotechnology by conceptually renewing tailored solid-state cell factories. FuturoLEAF introduces algal-based biocatalysts with functional architecture formulated from nanocellulose building blocks and designed on the principles of plant leaf anatomy and function. Knowledge of bio-based materials science and photosynthesis will be integrated with achievements of synthetic biology and biomolecular engineering to conceive the new technology efficient in capturing CO2 and producing solar-driven biofuels and chemicals. The FuturoLEAF biocatalysts will gain high production efficiency by tailoring nanocellulose matrix performance with utilisation of its highly specific water interactions, resulting in tunable porosity and transport properties. Directed self-assembly as a tool to locate and attach photosynthetic cells in the matrix by their native interaction potential will further improve the performance. The system will maximise light utilization and CO2 capturing by providing controllable influx/efflux of moisture, gases, nutrients, products and substrates, leading to next generation photosynthetic cell factories with high catalytic turn-over time. In addition, the solid-state nature of the system will enable effortless logistical transportation of cell factories without having to move large amounts of water in contrast to current suspension cultures. The FuturoLEAF architecture will be tested under changing environment in a fixedbed high-cell density photobioreactor, which is designed for simulating behaviour of the plant with gas-to-liquid interphase production environment. The proof of the concept will involve evaluation of the approach at T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cw and pulsed epr study of the structure and dynamics of photosystem ii' (1994-1998).

assistant: **Concept**

The structure and function of the reaction center of Photosystem II (PSII) will be studied by cw and pulsed EPR spectroscopy. (I) Electron Spin Echo Envelope Modulation (ESEEM) experiments will be performed on the triplet state of the primary electron donor of PSII (3P680) and the acceptor-side non-heme iron in its low-spin Fe3(S=1/2) form. The binding of NO, an inhibitor of the photosynthetic electron transfer of PSII, will be studied by ESEEM. The effect of the NO on the properties of the 3P680 will be monitored. (II) The spin-lattice relaxation of 3P680 with the non-heme iron in the high-(S=2) and low- (S=o) spin state will be studied; the detection of a dipolar coupling will allow the estimation of the Fe3-P680 distance. We will study the relaxation enhancement effect of Dy2+ on the acceptor-side radicals of PSII, the plastoquinone QA and the pheophytin Pheo. This will allow an estimate of the location of the radicals relative to the surface of the thylakoid membrane. The proposed research will result in original information about (a) the identity and the environment of certain paramagnetic centers in PSII i.e. 1H, 14N hyperfine interactions, hydrogend bonds, (b) the structural organisations of PSII i.e. distances between paramagnetic centers, ligand identification, (c) functional aspects of Photosystem II i.e. properties of the 3P680, the inhibotory effect of NO on the electron transport.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Distributed revision management in plant design'.

assistant: **Innovation**

This project focuses on an improved plant design process for saving costs and time and increasing quality, leading to better results in general.In most cases a plant is designed and built by a consortium of companies at different locations, frequently also of diverse nationalities. Each company is specialised in certain engineering areas, with a main contractor holding responsibility for the composition of the consortium and the execution of the project. During the design process, technical drawings and documents must be modified and adopted among the partners. In an ongoing project this becomes increasingly time-consuming and binds significant resources. The organisation of these processes, termed revision management, constitutes the main focus of this proposal.The intention is to provide a distributed revision management system for plant design based on distributed databases and allowing distributed teams to work on their individual tasks with the ability to access all relevant data concerning their project. Revisions can be made at any time and are visible to all partners immediately, thus enabling concurrent engineering on a level not available in plant design at present and therefore making significant cost and time savings possible. The revision management system requires an open and extensible kernel model in order to allow for the development of new, dedicated applications directly based on the kernel, as well as the connectivity of existing applications to the system. For the latter, an interface must be provided that is based on a STEP application protocol adopted for plant design purposes. Furthermore, the system kernel constitutes the link to the distributed database and must include revisioning and versioning capabilities. Due to the heterogeneous compositi