RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The biological clock and cancer' (CANCERTIME).

assistant: **Innovation**

The circadian clock generates and regulates many daily physiological and behavioural rhythms and thereby also influences the health of the organism. This knowledge has been useful for treating various diseases including cancer. In cancer therapy, survival rate and secondary effects can be improved by applying the treatment at the right time of day. However, the mechanisms by which the clock influences cancer development and treatment effects are not well understood. In the outgoing phase of the grant I will study how the functionality of circadian clocks in tumor and healthy tissue influences tumor development and response to treatment in Dr. Antoch’s research group at the Roswell Cancer Institute in Buffalo, USA. I will use a unique mouse model which allows visualization of the clock in real time by using bioluminescence imaging technology. I will study in vivo how changes in the clock relate to tumor development. I will further experimentally regulate the expression of clock genes to investigate how disrupting the clock affects tumor development both in vitro, using cell lines, and in vivo, by inoculating healthy mice with manipulated tumors. In a final step, in the return phase of the grant I will work together with Dr. Selivanova at the Karolinska Institutet in Stockholm, Sweden where I will test how potential anticancer drugs interact with the circadian clock and the apoptosis pathway.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Real-time Earthquake Risk Reduction for a Resilient Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The key concept and vision of RISE is to promote a paradigm shift in how earthquake risk is perceived and managed. We believe that by taking advantage of advances in scientific understanding, and dramatically changing technological capabilities, earthquake hazard and risk will soon be appreciated not as a constant in time, but as an evolving, integrated and dynamic risk. In our concept, dynamic risk depends on location, changing with soil conditions, topography, structural type, occupancy and use and even location within a structure. However, dynamic risk also includes changes with time, for example increasing when a seismic sequence is active nearby and due to an improved dynamic geophysical understanding of faulting and earthquake processes. RISE proposes a series of coordinated activities in the domains of Operational Earthquake Forecasting, Earthquake Early Warning, Rapid Loss Assessment and Recovery and Rebuilding Efforts. Our approach is multi-disciplinary, involving earth-scientists, engineering-scientists, computer scientists, and social scientists. It is multi-scale in space and time, and addresses these scales in a highly systemic and consistent way. RISE joins with EPOS Integrated Core Service and several of the Thematic Core Services (TCS), with ARISTOTLE and the Copernicus Emergency Management Service. Integration will also include responsible national agencies in Italy, Turkey, Iceland, Israel and Switzerland and with selected industry partners. To maximise the impact of RISE, we have assembled an interdisciplinary team of truly outstanding researchers and practitioners, 37 PIs from 24 institutions (including 5 contributing partners from outside of Europe), in 13 countries, with documented experience on the topics of the project developed in previous FP6,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced Lattice Structures for Composite Airframes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The ALaSCA project focuses on maximum weight and cost reduction significant in airframes by developing manufacture-optimized lattice fuselage structures fulfilling fundamental aspects of airworthiness.The idea behind the ALaSCA project is to perform a comprehensive investigation starting with the beneficial geodesic design well-proven in space technology and transferring it to composite aircraft fuselage designs. The main objectives of this research programme are: a) Maximum weight and cost reduction by using lattice designs for fuselage structures. b) Development of manufacture-optimized lattice designs satisfying airworthiness requirements. c) Verification of airworthiness by manufacture and testing of representative lattice components.Since structural requirements and boundary conditions in rocket technology are quite different from those in aircraft fuselage design, the scope of this project covers the specific aspects of design, sizing, manufacture and testing of lattice structures that follow from aircraft requirements. The objectives will only be achieved when solutions to the following issues in terms of lay-out, design, sizing, manufacture, and testing are found: a) Pro-lattice aircraft configurations for maximum weight and cost savings b) Aircraft specific components treated in the lattice fuselage design. c) Lattice elements, i.e. examination in the aircraft-specific detailed design of loads from impact and internal pressure.Applying the above-mentioned methodology, the objectives will be achieved by main innovations in the following areas: a) Structural concepts for long service-life periods b) Design and dimensioning of cut-out surround structures c) Optimized floor-barrel interface. d) Barrel-barrel interface. e) Aircraft configurations reducing the demand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DISCOVERING NEW DISEASE PATHWAYS AFFECTING mtDNA METABOLISM', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Defects of mitochondrial DNA (mtDNA) metabolism (maintenance, integrity and expression) are the most common cause of multiple mitochondrial respiratory chain (MRC) defects in children. Several new disease genes have been identified in these complex pathways but the functional link between mutant protein and mtDNA metabolism is unknown or poorly understood. Example of the latter is FBXL4 (F-box and leucine-rich repeat protein 4) gene, mutations of which have been recently found in 28 patients with a multisystem complex syndrome, hallmarked by combined MRC defect and reduction of mtDNA copy number in muscle and fibroblasts. Approximately 60% of patients still lack genetic definition of their disease. Objective of MITOBIOPATH proposal is the discovery and characterization of novel mitochondrial biogenetic and maintenance pathways by implementing three specific aims. 1) Gene discovering by whole exome sequencing (WES): unbiased WES screening will be applied to a large cohort of paediatric patients presenting early onset hypotonia, developmental delay, failure to thrive, severe encephalomyopathy and/or liver failure associated with combined MRC defects. 2) Pathogenic pathways revealed by new gene defects: functional studies using cellular and animal models (knock-out zebrafish or mouse models) will be performed to establish the pathogenic mechanism of the mutation(s) and the function of unknown disease-associated protein(s); 3) FBXL4 function in cellular and in vivo models: immortalized cell lines expressing six different FBXL4 mutations will be generated by using CRISP/Cas9 technology and characterized with a combined molecular, biochemical and proteomic approaches. In addition, proteins in the Parkin-proteasome complex were recently identified as potential partners of FBXl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New industrial process for footwear manufacturing using 3D Bonding' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The 3D BONDING project addresses a disruptive process, based on a family of patents (Simplicity Works- PCT/ES2012/07001369) for highly automated and robotised manufacturing of high-end footwear. Through a polymer injection process, we bond materials in 3D (instead of stitching), that creates a stable skeleton without overlapping seams, in a few seconds. This technology eliminates the need of complex stitching operations, improving the mechanical properties foot the footwear (adaptation, comfort, and permeability). 3D Bonding simplifies footwear manufacturing reducing the total number of operations to 20 (70 for traditional manufacturing), reducing labour costs associated to stitching and assembly by 72%, and using 50% less material. Moreover, the carbon footprint is 13% less than a traditionally made product. Our 3D BONDING project can bring back to EU the manufacturing process, resulting in reduced delivery times, multiple job positions and a stronger economy for the EU.


**Keywords:** Automation and control systems,Manufacturing and processing,Engineering and technology,3D bonding,footwear,Reaction injection molding,automation,Circular economy,robots
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Coordination Action for Aircraft Wake Turbulence' to be submitted under Seventh Framework.

assistant: **Abstract**

The Coordination Action WakeNet3-Europe will promote multidisciplinary exchange between research and operational specialists in the field of wake vortex turbulence. It will enable to develop a shared view on how to address capacity-related issues caused by wake turbulence. It continues the Thematic Networks WakeNet and WakeNet2-Europe. Safe separations prescribed to avoid potential hazards by encounters with a preceding aircraft’s wake are a main limiting factor for airport capacity. Increasing airport congestion and the introduction of very large aircraft initiated extensive investigations, involving researchers, aircraft and equipment manufacturers and operational users (airports, pilots, ATC). Two main questions are still open: · if the separations by MTOW can be replaced by a more physically based rulemaking, · if separations can be dynamically reduced with on-ground or on-board advisory and detection systems to increase airport capacity, both with constant or even increasing safety level. In the last decade activities have progressed from physical understanding to development of operational concepts and rulemaking. Several EU-funded and other projects are ongoing or starting in this field. For successful concept implementation, acceptance by operational users is mandatory. This requires continuous dialogue between scientists and users. Like previous Networks, WakeNet3-Europe will be the forum for this dialogue, building a bridge between wake vortex research and operations, in order to get scientifically funded agreement among stakeholders to support implementation, and to help making new technologies (e. g. advisory systems) usable for wake vortex purposes. WakeNet3-Europe will provide annual workshops open to the whole Wake Vortex community, establish focused Task
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders' to be submitted under Seventh Framework.

assistant: **Abstract**

The theme of this collaborative project is development and application of neuroimaging and bioinformatics tools to study lipid metabolism as a common pathogenic link between psychotic disorders and its metabolic co-morbidities. The overall objective is to identify, prioritize and evaluate multi-modal blood and neuroimaging markers with diagnostic potential for prediction and monitoring of psychotic disorders and associated metabolic co-morbidities. We aim to (1) optimise a multidisciplinary approach for combining positron emission tomography (PET) and magnetic resonance imaging (MRI) with metabolomics approaches, (2) develop a PET-method for exploring endocannabinoid pathways in early psychosis in longitudinal study setting, and (3) develop combined PET-MRI biomarker methodology for psychiatric disorders by studying neurotransmitter interactions with multiple PET scan and MRI sequences. The balance of two or more neurotransmitter systems may function as a novel biomarker in these disorders. The expected impacts are (1) etiopathogenic understanding, (2) new validated multi-modal markers for early disease detection and monitoring, (3) new tools for the identification of subjects who may benefit from specific treatment (4) discovery of new avenues for disease prevention and therapy, and (5) new tools and processes for applying brain imaging in personalised medicine. The consortium brings together clinicians, researchers and industry partners in the domains of psychiatry, neuroimaging, metabolic research, systems biology and bioinformatics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Exploring pathways for transformation to sustainability using the safe and just operating space concept at the regional level'.

assistant: **Objectives**

SUccESS aims at identifying transformation pathways towards sustainability that are both safe, in terms of being within the ecological boundaries of a place, and just, in terms of being socially just. To achieve this at regional level, ecological boundaries and social foundations will be assessed, and these variables will be related to: 1) social foundations that need to be secured to avoid human deprivation; and 2) stakeholder's mental models of change, for chosen cases from Kenya. Based on these relationships, the initiative will explore pathways using a systems dynamic approach to ensure a safe and just operating space (SJOS) for transformation to sustainability. This integrative approach provides an innovative way to address the sustainability of social-ecological systems (SES) and their transformation options in a globalized context. This will also help to develop methodology aimed at defining boundaries for sustainable development that can be applied to identify tipping points, limits to growth and limits to adaptation across the world.


**Keywords:** Sustainable development, safe and Just operating space,  social-ecological system, system dynamic modelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Two Dimensional Materials for Bolometers of the Future'.

assistant: **Concept**

Remote thermal sensing and imaging is currently one of the most prominent technological fields. Its market value is expected to grow beyond $10 billion/year by 2020. The simplicity and low price of uncooled radiation heat sensors, bolometers, have made them subjected for extensive research. The route for improved performance is enhanced absorption of thermal radiation, improved thermal isolation, reduced thermal mass, increased sensitivity of thermal transduction and reduced noise.Atomically thin crystalline materials, 2D materials, are an attractive alternative to traditional bolometer materials. Their extreme aspect ratio allows for excellent thermal isolation, low thermal mass, and electrostatically tunable electrical and optical properties allows for temperature sensing and strong light-matter interaction.FUTBOL aims to take the advantage of 2D materials, as new bolometer material, to create a novel sensor with unseen resolution and bandwidth. A strip of 2D material is suspended to thermally isolate it from its surroundings and form a Fabry-Pérot cavity. Thermal radiation is partly absorbed and partly transmitted into the cavity where it resonates. As the 2D material is not a perfect mirror it will eventually absorb a large fraction of the radiation. The conductivity of the 2D material is electrostatically tuned, using the gate voltage, to maximize absorption.  It is utilized that an ultrathin metallic layer reaches 100% absorption when its resistance equals the product of the layer thickness times the vacuum impedance. Absorption of radiation leads to heating of the thermally self-sensing 2D material which is transduced either via changes in its electrical resistance or mechanical resonance frequency. Advantages of the bolometer design are minimal thermal mass, exc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'BIOCOPY: the new biomolecule copying and screening solution for diagnostics and therapeutics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

BioCopy is a spin-off company borned in the University of Freiburg. We have developed an innovative, patented technique to copy biomolecules analogous to a photocopier. A DNA-coated surface is used as copy template. By supplying different biochemical ""copy mixes"", either a DNA, a RNA or a protein copy is generated. After the copy process, the copied biomolecules can be analyzed label-free for their specific binding to target molecules and recovered as potential candidates for a future use as therapeutics or diagnostics. The BioCopy technology completely opens up new dimensions for drug development, vaccines, antibodies, enzymes, catalysts, bioactive coatings, and biosensors and it has are more than 40 future applications. We plan to offer 3 products and services to pharma and biotech companies, related with high- output and cheaper molecular biology screenings. The most promising line is the tailor-made discovery of vaccine candidates within two days. This will have a disruptive character, because the first generation of a vaccine is a billion-dollar market, projected to rise $60 billion on 2019, with 11% growth per annum, and to $100 billion by 2025. BioCopy will provide vaccine candidates to pharmaceuticals, obtaining revenues through upfront, milestone and royalty payments, and they will be responsible for the vaccine´s clinical development, approval and distribution. The multi-awarded BioCopy team covers business know-how and expertise in biology, physics, manufacturing systems engineering, assay development and microsystems technology. BioCopy aims to contribute to the European challenges related with advanced biotechnology applications in pharma sector, and to increase the technological transfer from the academic world into the manufacturing sector. During phase
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enhanced Networking on Antimicrobial Resistance Surveillance with Next Generation Sequencing' (AmReSu).

assistant: **Innovation**

Our project “Enhanced networking on antimicrobial resistance surveillance with NGS” brings together Semmelweis University (SU) and Klinika Za Infektivne Bolesti „Dr. Fran Mihaljevic (BFM) with two internationally leading research institutions, Laboratory of Medical Microbiology (LMM), University of Antwerp (UAntwerp) and the Health Research Institute of the Balearic Islands (IdISBa) , on the topic of Antimicrobial resistance surveillance with whole genome sequencing (WGS) in correlation next-generation sequencing techniques. Our aim in AmReSu is to strengthen, to the highest European level, Semmelweis University (SU)’s and Klinika Za Infektivne Bolesti „Dr. Fran Mihaljevic” (BFM)’s scientific excellence and innovation capacity in Antimicrobial resistance surveillance and to set-up an ‘Antimicrobial resistance surveillance vision’ in Hungary and Croatia.Strenghtening antimicrobial resistance (AMR) surveillance is also in line with the Hungarian National Smart Specialisation Strategy  and the Croatian National Programe for Antibiotic Resistance Control. AMR bacterial infections are a global threat, they are responsible for increased morbidity and mortality rates in Hungary and Croatia, especially in cases of nosocomial infection. Many previously manageable bacterial infections are becoming increasingly hard to treat. Rising rates of resistance amplify the morbidity and economic burden associated with infections.An estimated 700,000 deaths attributable to AMR every year in the world, and a projected 10 million deaths per year by 2050 in the absence of additional control measures. The core activities of our project are knowledge transfer, exchanges of best practices via a number of institutional networkingand training activities, including workshops, conferences, summer sch