RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cold atoms and ultra-precise atomic clocks' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The objectives of the training programme are threefold:* to provide the young researchers with the skills required for the successful completion of the research project;* to provide the young researchers with skills and competencies which will enable them to serve as researchers in the most technologically advanced branches of European industry;* to provide the young researchers with an understanding of the importance of basic science not only for the continued advancement of technology, but also for the cultural state of the European Community. Pre-doctoral researchers will receive training from the doctoral programmes of the universities involved in the network. The pooling of resources from 5 universities in 4 countries will allow for a substantial added value over and above what could be realized in the individual countries. Both pre- and post-doctoral researchers will receive additional training through workshops organized by the network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovating Industrial Production Technology for Custom-Made Casted Gear Boxes' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research and Technical Development into custom-made casted gear boxes and the flexible industrial production technology to manufacture casted instead of welded gear boxes. 3D CAD/CAM tools will be integrated in the design and manufacturing system and links to design and production equipment will be made in order to speed-up and optimize the design, set-up, production and control of these casted gear boxes. The manufacturing objective of this research project is to obtain product and production technology knowledge to produce high quality custom-made casted gear boxes with shorter delivery times, lower product costs and allowing less similar units per order.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A study of TGF-beta effects on breast cancer stem cells' (2007-2013) under Seventh Framework.

assistant: **Objectives**

A highly tumourigenic subpopulation of cancer cells has recently been identified in primary and metastastatic breast cancer. This minority of cells termed tumour-initiating cells or “cancer stem cells“ (CSC) has been shown in several solid tumours to bear stem cell features such as the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumour. Correlating with this, several pathways and genes required for normal stem-cell function are activated in cancer cells and play essential roles in tumourigenesis. However, the specific molecular mechanisms through which CSCs exert their tumourigenic effects remain unknown. The TGF-beta pathway is a key player in mammalian biology, and its misregulation can result in tumour development. Increasing evidences are starting to elucidate the mechanistic basis and clinical relevance of TGF-beta’s role in cancer, yet its complex and pleiotropic nature requires still a much profound understanding of the pathway. The proposed project aims to study a yet unidentified role of TGF-beta in breast cancer stem cell regulation by analyzing human breast cancer cell lines as well as fresh breast tissue samples derived from primary tumours and malignant pleural effusions from patients with breast cancer of diverse grade and stage. TGF-beta regulation of the different subtypes of breast progenitor cells will be assess by colony forming cell and mammosphere-initiating cells assays as well as by an innovative xenotransplantation assay in vitro and in vivo respectively. Moreover, a transcriptomic approach will be designed to discern the mechanisms and molecular determinants of TGF-beta's role in breast stem cell regulation. By developing this project, we will decipher how TGF-beta regulates breast stem/progen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Echoes of Rome: Deciphering Hispania’s Coinage Origins with Lead Isotope Analysis'.

assistant: **Concept**

The analysis of lead isotopes in Roman coins has gained significant popularity in recent years. Several ERC-funded projects provide clear evidence of the scientific interest in ancient coins and their isotopic results. Today, lead isotope analysis is the most effective method for establishing the geographical origin of lead present in ancient metals or coins. The project “Echoes of Rome: Deciphering Hispania’s Coinage Origins with Lead Isotope Analysis” is based on this multidisciplinary approach. Despite these advancements, the supply of metals to Roman provincial cities for minting bronze coins remains a mystery, and a holistic view has yet to be addressed. Through the ECO project, I will analyze the provincial bronze coinage of Hispania. Additionally, the lead isotopic results obtained by MC-ICP-MS will be compared. This comparison will provide a solid foundation for future research. The progress achieved in terms of origin, supply, and distribution will be highly regarded by scholars. Furthermore, the combined use of epigraphic and archaeological sources, along with new data provided by isotopic analysis, will enhance our understanding of the economic history of the Roman Empire, particularly Hispania, one of the most prosperous and significant regions of the Mediterranean. Finally, the archaeological and mining context of Hispania and its development are of paramount importance to the Roman Empire. The mining areas of Cartagena-La Unión and Linares-La Carolina were, for decades, Rome’s main source of silver.


**Keywords:** Numismatics, Ancient coins, Roman coinage, bronze coins, Roman mining, metal supply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Ars Nova: Multilingual Poetry and Polyphonic Song in the Late Middle Ages' (ArsNova) under Horizon 2020.

assistant: **Objectives**

Dante Alighieri at the dawn of the 1300s, as well as Eustache Deschamps almost a century later, conceived poetry as music in itself. But what happens with poetry when it is involved in the complex architecture of polyphony? The aim of this project is to study for the first time the corpus of 14th- and early 15th-century poetry set to music by Ars Nova polyphonists (more than 1200 texts). This repertoire gathers different poetic and musical traditions, as shown by the multilingual anthologies copied during the last years of the Schism. The choice of this corpus is motivated by two primary goals: a) to offer a new interpretation of its meaning and function in the cultural and historical context, one that may be then applied to the rest of coeval European lyric poetry; b) to overcome current disciplinary divisions in order to generate a new methodological balance between the project’s two main fields of interest (Comparative Literature / Musicology). Most Ars Nova polyphonists were directly associated with religious institutions. In many texts, the language of courtly love expresses the values of caritas, the theological virtue that guides wise rulers and leads them to desire the common good. Thus, the poetic figure of the lover becomes a metaphor for the political man, and love poetry can be used as a device for diplomacy, as well as for personal and institutional propaganda. From this unprecedented point of view, the project will develop three research lines in response to the following questions: 1) How is the relationship between poetry and music, and how is the dialogue between the different poetic and musical traditions viewed in relation to each context of production? 2) To what extent does Ars Nova poetry take part in the ‘soft power’ strategies exercised by the en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'First principle molecular dynamics simulations for complex chemical transformations in nanoporous materials'.

assistant: **Innovation**

Chemical transformations in nanoporous materials are vital in many application domains, such as catalysis, molecular separations, sustainable chemistry,….  Model-guided design is indispensable to tailoring materials at the nanometer scale level.    At real operating conditions, chemical transformations taking place at the nanometer scale have a very complex nature, due to the interplay of several factors such as the number of particles present in the pores of the material, framework flexibility, competitive pathways, entropy effects,…  The textbook concept of a single transition state is far too simplistic in such cases.  A restricted number of configurations of the potential energy surface is not sufficient to capture the complexity of the transformation.    My objective is to simulate complex chemical transformations in nanoporous materials using first principle molecular dynamics methods at real operating conditions, capturing the full complexity of the free energy surface.  To achieve these goals advanced sampling methods will be used to explore the interesting regions of the free energy surface. The number of guest molecules at real operating conditions will be derived and the diffusion of small molecules through pores with blocking molecules will be studied.  New theoretical models will be developed to keep track of both the framework flexibility and entropy of the lattice.  The selected applications are timely and rely on an extensive network with prominent experimental partners.  The applications will encompass contemporary catalytic conversions in zeolites, active site engineering in metal organic frameworks and structural transitions in nanoporous materials, and the expected outcomes will have the potential to yield groundbreaking new insights.  The results  a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Anal Fistula Treatment' (BioHealx).

assistant: **Concept**

Signum Surgical Ltd. is a medical device company developing a solution to anal fistula disease. Anal fistulas are a common rectal disease affecting 2 out of every 10,000 people globally. An anal fistula is an artificial tunnel that, in the majority of cases, develops from an infection that begins within a blocked anal gland.  If the infection cannot be cleared from the anal gland an abscess forms and the infection burrows though muscles in the rectum and exits externally at the buttocks.  Patients endure a poor quality of life, experiencing pain associated with the tract and related abscesses and suffering faecal, pus and blood discharge from the fistula tract. Many patients must wear pads to control leakage, and those who seek treatment face poor surgical outcomes.There is currently no gold standard treatment for anal fistula treatment, which has not changed significantly in over 2,500 years when Hippocrates described using horse hair and silk to drain the fistula tracts. Surgeons are frustrated with the commercially available treatment options which either result in inadequate healing of the initial condition, introduce incontinence as a consequence of surgical treatment, or result in repeat procedures and additional cost to health care system.Through close collaboration with expert colorectal surgeons, Signum Surgical has developed the BioHealx device - an intuitive novel single use technology which improves upon current state of the art devices and surgical procedures to meet all identified critical clinical requirements to reliably heal anal fistulas. During this H2020 project, the company seek to demonstrate the technology in man to enable product launch and growth of sales in the U.S. and Europe.


**Keywords:** Anal Fistula disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Innovations in Fluvial Environmental Research:Core Scanning of Flood and Contaminant Histories'.

assistant: **Innovation**

River floodplain sediments can provide valuable information on climate, land-use and pollution histories that can support sustainable river management objectives. In this project, the applicant will use a unique collection of state-of-the-art analytical technologies at University College Dublin, Ireland, to develop and test approaches for unlocking these floodplain sediment archives in an holistic and novel manner. At the centre of the project is the application of micro-XRF core scanning which permits rapid, non-destructive chemical analysis of sediments at sub-mm resolutions. These new technologies, that have the potential to revolutionise geochemical research and applications in floodplain environments, will be tested against complementary geochemical and high resolution imaging techniques for the purpose of reconstructing (i) contaminant heavy metal concentrations and (ii) flooding histories in Irish and UK catchments. The candidate will gain technical skills in the preparation and analysis of samples, together with training in environmental geochemistry, cutting edge high resolution image analysis and statistics that will complement her understanding of fluvial geomorphology and sedimentology. Furthermore, through an established Performance Management Development System at the host institution, a programme of training will provide the applicant with opportunities to enhance her teaching and project management skills and gain instruction and experience in research writing, presentation and supervision that will leave her exceptionally well-placed to pursue an academic career. The innovative research required to fulfil the project’s objectives will enhance excellence and knowledge transfer within the European Research Area by providing guidance for future research in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'IDEA-Foot: Innovative DEsign and mAnufacturing systems for small series production for European FOOTwear companies' (IDEA-FOOT) targeting Seventh Framework.

assistant: **Abstract**

The reference scenario for the IDEA-foot project is theEuropean SMEs working in the footwear industry and in particular in the market segment of classical and casual shoes. The global competition is asking for the reduction of Time to Market, increase of products diversification also with a small batch production while keeping a high fashion and quality content of the product. The actual design and production processes result to be not suitable for this small batch and variegated production. In particular the actual design and industrialization processes follow a serial model, in which the semifinished shoe model is necessary for the sequential development of the other shoe components to be assembled. Moreover the production process has an handicraft connotation: the operators program and feed manually the semiautomatic machineries for each batch of shoes.  The aim of the project IDEA-foot are: • the introduction of a new method for the integrated design and production of the shoe, in which the key elements are the standardization of the shoe components and the transfer of the geometrical information from the design to the production process in a digital standard data format; • the development of a CAD software module to ease the design of components according to the standards; • the development of a CAM software which transfers the production parameters from the CAD models to the production machineries using a standard data format, which is another enabling technology just developed, and is able to integrate the machineries with the manipulation system; • the development of an automated production cell by enhancing the interfaces of existing machineries which are going to be modified in order to work in an integrated/synchronised way. An automatic manipulation system i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'NAture Insurance value: Assessment and Demonstration' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

NAIAD aims to operationalise the insurance value of ecosystems to reduce the human and economic cost of risks associated with water (floods and drought) by developing and testing - with key insurers and municipalities - the concepts, tools, applications and instruments (business models) necessary for its mainstreaming. We will do this in detail for 8 demonstration sites (DEMOs) throughout Europe and develop tools and methods applicable and transferable across all of Europe. The assumption is that Natural Assurance Schemes can reduce risk, especially to drought and flooding, and this risk reduction can be assessed and incorporated within insurance schemes. NAIAD´s conceptual frame is based on three pillars:(i) to help build a resilience approach to risk management through nature based solutions, (ii) the operationalisation and testing of scientific methods using a source-to-sea in DEMOs,(iii) the uptake of nature based solutions that are cost-effective and provide environmental, social and economic benefits.Trans-disciplinarity and stakeholder engagement are at the core of NAIAD for two reasons: first, because the conceptual and assessment methodologies combine physical, social and cultural and economic aspects, integrated into tools and methods but second, and most importantly “road tested” and validated with the stakeholders and end users themselves at the DEMOs. NAIAD will contribute to providing a robust framework for assessing insurance value for ecosystem services by (i) enabling full operationalisation through improved understanding of ecosystem functionality and its insurance value at a broad range of scales in both urban and rural context; (ii) making explicit the links between ecosystem values and social risk perception; and (iii) the application of developed m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'FAMILY MATTERS: POST-NATAL SOCIALITY AND THE OUTCOMES OF MATERNAL STRESS IN A SOCIAL LIZARD'.

assistant: **Objectives**

Mothers can alter the characteristics of their offspring through non-genetic maternal effects. For example, stress experienced by mothers during gestation can have organizational effects on offspring behaviour and physiology – such effects may substantially influence the subsequent success of these offspring. Theory suggests that, depending on the environment in which they occur, maternal effects have the potential to accelerate or constrain the rate, and alter the direction, of evolutionary change. It is therefore critical to know how ecological variation influences the outcomes of maternal effects, such as maternal stress effects, in order to understand the evolutionary importance of maternal effects in different species. A source of environmental variation likely to be important in determining the outcome of maternal effects, and maternal stress specifically, is the post-natal social environment – in other words, whether offspring remain with their mother/parents, or not. I propose an integrative research project to test how the outcomes of maternal stress are influenced by the post-natal social environment. To achieve this, I will combine a large-scale field experiment using a social lizard species (Liopholis whitii) in which the degree of post-natal mother-offspring association varies naturally, with physiological laboratory analysis and meta-analytical methods to: experimentally address how the post-natal social environment alters the effects of maternal stress on key phenotypic traits (such as growth, and dispersal and competitive behaviours), identify potential endocrinological and neurological mechanisms underlying these effects, and test the generality of these patterns across taxa in a meta-analytical framework. This work will provide novel insights into the