RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biomechanics in health and disease: advanced physical tools for innovative early diagnosis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Phys2BioMed will offer excellent interdisciplinary and cross-sectoral training to a team of motivated early stage researchers (ESRs) on the application of cutting-edge physical tools for the mechanical phenotyping of cells and tissues of clinical relevance, aiming at developing novel early-diagnostic tools. The Phys2BioMed network will merge diverse competences at European level, from different fields like nanoscience and nanotechnology, physics, biology, and medicine, and will expose ESRs to the non academic and private sector. A key element of the project is the peer-to-peer collaboration of research academic institutions with industries and world-leading medical and clinical centers; these are the main actors of the global challenge against diseases, and within Phys2BioMed they will highlight unmet clinical needs, and actively cooperate with academic colleagues for developing novel diagnostic strategies. ESRs will be trained-through-research by world-leading junior and senior PIs, and will benefit of lecture courses, dedicated international schools and workshops, and topical conferences. Secondments to other nodes of the network will represent the main and more effective channel of dissemination and cross-fertilization of competences, ideas, and knowledge within the network. Besides training talented young scientists, ready to work at the boundary of diverse disciplines in the field of nanomedicine, Phys2BioMed will provide scientific and technological outcomes on biomechanics, and the mechanical determinants of diseases. Technology-wise, it will define standardized procedures for nanomechanical measurements, and the definition of the main features of new-generation instrumentation optimized for the mechanical phenotyping of clinical specimens. In the longer-term, Ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Silicon-Integrated Graphene Photodetectors for Future Photonic Integrated Circuits – Graph-IC' to be submitted under Horizon 2020.

assistant: **Abstract**

The goal of the Graph-IC proof of concept proposal is to verify the innovation potential of silicon-technology-integrated graphene photodetectors for high-speed and broadband light conversion. The idea of this PoC is to use such graphene photodetectors as an enabling technology for integrated optoelectronic systems with extremely high data rates. The new technology will be fully integrated and allow the utilization of the entire transmission window of optical fibers. Such systems have the potential to decisively outperform existing systems in terms of data-rate, cost and energy consumption, which are becoming major challenges in large data systems. Within this PoC, we plan to establish the viability and identify technical issues of integrated graphene photodetectors with high electrical bandwidth for optical wavelengths. Graph-IC prepares the PI and his team to embark on a very high-risk, very high-gain endeavor, where the goal is to compete in a multi-billion Euro global market. This proposal is based on the scientific results of the ERC starting grant “InteGraDe – Integrating Graphene Devices (307311)”, where the PI has demonstrated the integration of graphene with silicon technology up to the wafer scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Elucidating novel roles and mechanisms of the GAD system in stress resistance and virulence of Listeria monocytogenes' to be submitted under Seventh Framework.

assistant: **Abstract**

In previous work performed by Dr. Karatzas it has been demonstrated that the presence of glutamate does not confer any acid resistance to L. monocytogenes grown in DM. This is due to the absence of any GABA export in this medium even if glutamate is present.  Furthermore, L. monocytogenes accumulates high levels of intracellular GABA when challenged with HCl in both rich media like BHI and DM. This accumulation of GABA intracellularly suggests that this response might protect cells under acidic conditions. We propose that the accumulation of intracellular but also of extracellular GABA buffers the acidic envinronment and therefore protects the cells. This hypothesis will be tested and the role of intracellular GABA will be assessed with experiments performed in a mutant missing all the decarboxylases. Furthermore, it is proposed to identify the source of intracellular GABA which is probably intracellular glutamate. In addition it will be investigated if any of the three decarboxylases is responsible specifically for the production of intracellular GABA. In previous work performed by Dr. Karatzas it has been demonstrated that previously unknown components in BHI activate the expression and the function of the GAD system in terms of GABA export. We propose to specifically identify these components and investigate if the regulation is at transcription level or if they are required for the activity of the antiporter-based GAD system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Realistic simulation of light for general environments' in the context of a Fourth Framework call.

assistant: **Objectives**

In this project we will study and present solutions to these problems by developing new state- of-the-art algorithms allowing the treatment of general materials and participating media. A second major objective is the construction or working prototype demonstrators for real applications in collaboration with industrial and other end user partners.Approach to Achieve the ObjectivesThe problems we address are unsolved research issues. In Phase 1 we will develop and attempt to validate new algorithmic solutions, with a strong emphasis on integration into existing software platforms. Prototype plug-in software components will be developed that will be integrated into the partners software bases, exploiting their expertise and the capacity to provide extensible and reusable software incorporating significant technological advances. Phase 2 will include further development and extension of the new algorithms and collaboration with industrial partners for the creation of working prototype demonstrators of the new technology in real applications.Results:By permitting the treatment of a much wider range of materials (glossy and shiny surfaces) and environment types (fog, smoke) the use of realistic lighting simulation techniques will become more widely applicable. As a result, designers and simulation experts in application domains such as architecture and interior design, luminaire design, road safety or driving simulation will become potential users of realistically lit digital mock-ups. This will permit higher quality pre-fabrication design and a large reduction in (re-)design costs.Interest expressed by potential users show that the goals of the project could be applied indomains such as luminaire design, road safety, CAD/CAM etc..Prototype plug in software components (avail
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Precedents for Algal Adaptation to Atmospheric CO2: New indicators for eukaryotic algal response to the last 60 million years of CO2 variation' in the context of a Seventh Framework call.

assistant: **Objectives**

Evolution of marine algae over the last 60 million years has resulted in a fundamental change in the efficiency of biological carbon pump and shift from communities dominated by calcifying algae (like coccolithophorids) to siliceous diatoms and major size class changes among these groups. The inferred shift in atmospheric CO2 over this time period has been suggested as an important selective pressure on some of these responses, including diatom adaptation to lower atmospheric CO2 concentrations via use of the C4 photosynthetic pathway, and trends towards smaller coccolithophorid cell sizes in response to greater C limitation. If current trends continue, future changes in atmospheric CO2 from anthropogenic activities are likely to reach levels last seen in the Eocene by the end of the next century; such changes will also be accompanied by ocean acidification and changes in stratification. Evidence suggests that modern calcifying algae and diatoms may employ a range of carbon acquisition strategies (such as active carbon concentrating mechanisms) according to the pH and carbon speciation of the seawater in which they live. However calcifying populations from 60 million years ago apparently had a single or less diverse array of carbon acquisition strategies. In this project we thus seek to 1) to identify and calibrate novel fossil indicators for adaptation and evolution in carbon acquisition strategies in eukaryotic algae in response to past changes in the carbon cycle and atmospheric CO2, and 2) apply these indicators to establish the nature and timing of changes in carbon acquisition strategies by algae over the past 60 million years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting atherosclerosis: Raman-spectroscopy validated, triggered release of drugs from de novo phospholipid-incorporating liposomes by sphingomyelinase enzymatic degradation of the membrane bilayer' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Cardiovascular diseases are the world’s number one killer, causing  43% of all deaths and costing the EU 192 billion Euros annually. Delaying their progression using e.g. targeted drug delivery to atherosclerotic plaques is a number one priority in modern healthcare.The enzyme sphingomyelinase (SMase) is upregulated in atherosclerotic plaques. In vivo, dysregulation of enzymatic conversion of the cell membrane phospholipid sphingomyelin (SM) to ceramide by SMase leads to a change in ceramide concentration. This causes endothelial dysfunction, atherosclerosis, ischemic heart disease, emphysema, cancers, cystic fibrosis and depression. SMase-targeting drugs are an emerging research topic but no localised delivery vectors to alleviate negative systemic side effects are yet reported. This project marks two world-firsts: SMase as a target for drug delivery, and a liposome formulation from which release is not only targeted but ENDOGENOUSLY TRIGGERED by the target enzyme.SM analogues will be synthesised and incorporated into the membrane bilayer of drug-loaded liposomes.  The ceramide analogue products they form on enzymatic reaction with SMase create drug-eluting pores in regions of high SMase activity (i.e. atherosclerosis) and release an encapsulated drug, but unlike natural ceramides do not interact with cells to trigger responses such as apoptosis. For the first time, toxicity of SM analogues and efficacy of the optimised liposome delivery vectors will be measured on human vascular endothelial cells using state-of-the-art live cell Raman microspectroscopy, which can highlight subtle differences in lipid and cholesterol production and distribution and cell cycle.This never before reported drug delivery platform can be translated to treat many SMase dysregulating pathologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'The role of atrial dilatation in development of chronic atrial fibrillation'.

assistant: **Objectives**

The project investigates whether chronic a trial dilatation plays a causal role in a trial fibrillation. It uses a new method in a well-established goat model and will help to develop effective therapeutic strategies against this important arrhythmia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evaluation and user assessment of lighting systems performance', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives Carefully planned use of natural light for indoor lighting has positive effects on the overall building energy demand. Because of the variable nature of daylight and in order to avoid visually unacceptable conditions, this must be done in a controlled way, which is possible using advanced daylighting systems. It requires also an electronic control of the supplementary artificial lighting. The performance of such combined systems is not yet understood in a quantitative way. Two issues are crucial for the success of any integrated daylighting/controls system: the energy savings and the user acceptance. A minimum of 2 and a maximum of 4 systems will be evaluated both in practice and under laboratory conditions. The evaluation includes both energy saving potential and user acceptance. This way it is anticipated to develop a method for the performance prediction of real systems on the basis of simple laboratory tests. Technical Approach The overall system performance must be evaluated in direct comparison to conventional systems, i.e. windows without any electronic controls. The performance evaluation must include the artificial lighting system and the appropriate controls. It is not sufficient to measure workplane illumination levels. Luminance distributions are probably more important and shall be evaluated as well. The comparison will be performed in defined, unused full-scale test rooms. In order to provide methods for future comparative evaluation studies, parallel investigations using scaled models under an artificial sky and computer simulations will be carried out, compared to the test room results, modified, if necessary, and validated. The user reaction is determined in three different ways: One of these methods is based on computer simulation by creatin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Obsidian Trade at the Onset of the Neolithic in the Near East. Assessing Obsidian Tool Use and Modelling Exchange Networks.' in the context of a Horizon 2020 call.

assistant: **Objectives**

ObsTrade is designed to understand obsidian trade at the onset of the Neolithic in the Near East. Long distance exchange is considered the marker of emergent social networks allowing interactions between distant villages. ObsTrade assumes that these networks improved modes of cultural accumulation of prehistoric societies. This was fundamental for the emergence and transmission of innovations during the transition to farming. For understanding obsidian trade, ObsTrade will investigate what traded obsidian tools were used for and how they were exchanged. The project proposes an original, innovative and interdisciplinary approach, by analysing Neolithic obsidian tool function and geographical distribution. Two cutting-edge methodologies will be applied: 1) the high-precision surface texture analysis through Confocal Scanning Microscopy (CSM) and metrology software for the identification of tool use; 2) the Complex Systems theory and modelling for characterising the obsidian exchange networks and their involvement in the emergence and spread of innovations. An Open Access database (ObsTrade database) containing all data about obsidian presence, geological origins, distribution and use in Near Eastern Neolithic sites will be created. Project results will be made available to the general public through the creation of a graphic novel, and through several outreach activities. The ObsTrade project will allow gaining a better understanding of the mechanisms underlying the formation of the first complex farming societies, using innovative methodologies that will contribute notably to European excellence and competitiveness.


**Keywords:** Use-wear analysis,  Confocal Scanning Microscopy,  Obsidian Trade,  Complexe Network Analysis,  Diffusion of innovations,  Prehistoric Techno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multi-National External Quality Assay (EQA) programmes in Clinical Molecular Diagnostics based on Performance and Interpretation of PCR assay methods including dissemination and training' (EQA) under Sixth Framework.

assistant: **Objectives**

Molecular Diagnostics are available for Clinical Chemistry and Medical Genetic laboratories and international regulatory organisms have already developed guidelines, recommendations and External quality assurance (EQA) programmes to safeguard their quality. But up today EQA programs for specific DNA targets remain limited to a few tests. Moreover these regulatory organisms are concerned about the possibility to keep up with new EQA programmes addressed to the expected growth rate of new diagnostic tests. EQA programmes directed to the evaluation of the analytical aspects common to the majority of the molecular diagnostics can be proposed and these methodological EQA programmes may be valuable with the existing EQA programmes or in absence of them. The Partners of the Project, Coordinators of EQA programmes of molecular diagnostics already implemented at national or international level, propose a panel of'EQA programmes on Performance and Interpretation of PCR based assay methods. These methodological EQA programmes will be available to laboratories performing Molecular Diagnostics on a voluntary basis for monitoring performances of technical procedures common to most of these methods. Specifically developed questionnaires and procedures of data analysis will be implemented for monitoring efficacy and appreciation of these EQA programmes. Diffusion of these EQA programmes to other countries will be supported through international organisms of the area of Laboratory Medicine, such as EC4. Finally specific training courses will be organised by the partners for the participants of this survey in order to improve both technical and interpretation skills required for the correct use of these molecular diagnostic tests. It is expected that integration between EQA programmes ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'From inspiral to kilonova'.

assistant: **Concept**

Recent years have seen the blossoming of multi-messenger astrophysics where gravitational waves, photons and neutrinos provide complementary views on cosmic explosions involving some of the Universe’s most enigmatic objects, namely neutron stars and black holes. The first observation of a neutron star merger via both gravitational waves and, days later, an electromagnetic flash called ""kilonova"" enabled huge scientific leaps forward and was therefore celebrated as ""2017 Breakthrough of the Year"". Multi-messenger astrophysics has an enormous potential to solve many longstanding puzzles such as the origin of the heaviest elements or the nature of the densest matter in the Universe, provided that we understand how the different messengers are physically connected. The gravitational wave and electromagnetic emission stages, however, involve vastly different length and time scales and completely different physical processes. Therefore, currently strong assumptions need to be made how both stages are actually physically connected.    On the verge of this transformational era of physics, I propose to calculate for the first time the evolution from the inspiral (milliseconds before the merger) to the time after the kilonova (months later) within a common simulation framework. This will become possible via the novel computational methodology that I have recently developed: the world-wide first Lagrangian hydrodynamics code that also consistently solves Einstein's equations. Compared to conventional Numerical Relativity codes, my new development has major advantages in evolving the merger ejecta which finally cause the kilonova. This project will provide for the first time detailed physical structures of neutron star merger remnants and the first one-to-one mapping between th