RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functions of Integrins in Mammary Stem Cell Activity and Tumorigenesis' (INTEGRISTEM).

assistant: **Innovation**

Understanding the functional interactions between mammary epithelium and its microenvironment, with a particular focus on the stem cell niche, represents a challenge for developmental and cancer biologists. Mammary epithelium is a bilayer, with a layer of luminal cells, producing milk, and a layer of basal myoepithelial cells. Both layers contain clonogenic stem/progenitor cells, which ensure the drastic epithelial expansion in puberty and pregnancy. Whilst basal stem cells are thought to be bipotent, luminal progenitors appear to be lineage-restricted in normal gland. Recent studies indicated that basal-like breast tumors, notably those with BRCA1 mutations, might originate from luminal progenitors. Our project aims to elucidate the role of integrin receptors for Laminin, major component of the mammary basement membrane, in the regulation of the luminal progenitor function during normal mammary development and tumorigenesis. To this end, α3 and α6 integrin chains were deleted from mammary luminal cells in vivo using CreLoxP system. Cre expression was driven to luminal progenitors by the Blg promoter, activated in this cell population in adult virgin mice and further on, during lobulo-alveolar development in pregnancy. The stem cell activity and the maintenance of the stem cell populations in mutant mammary glands will be analyzed at different developmental stages. Morphogenesis, proliferation, survival, differentiation as well as the regenerative and clonogenic potential of the mutant epithelium will be examined. We will study the cytoskeleton organization and the capacity of mutant cells for baso-apical polarization. To analyze the responses of integrin-depleted cells to hormones and growth factors at the molecular level, organotypic ex vivo cultures will be employed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Ethical aspects of deinstitutionalization in mental health care'.

assistant: **Concept**

OBJECTIVESEthical aspects of deinstitutionalization in mental health care and deinstitutionalization issues.This study focuses on the ethical dilemmas posed by deinstitutionalization in mental health care. Deinstitutionalization is a process involving three elements: a) the move of institutional patients to the community b) the concurrent expansion of community-based services for the treatment of these individuals c) the avoidance of traditional institutional settings for the care of the mentally ill.This study focuses on the ethical dilemmas posed by deinstitutionalization in mental health care. Deinstitutionalization is a process involving three elements:a) the move of institutional patients to the community;b) the concurrent expansion of community-based services for the treatment of these individualsc) the avoidance of traditional institutional settings for the care of the mentally ill. Increasingly, people with severe mental health problems live in the community -whether in their own homes or in (semi-) residential care - rather than in psychiatric hospitals. Deinstitutionalization takes place all over Europe, although the way this transformation of mental health care is realized differs considerably between countries. The five countries who participate in this study (The Netherlands, Greece, Belgium, Italy, England) vary in the pace of deinstitutionalization, in their regulations of this process, in the organization and the intensity of the community based services and in the way the (unintended) consequences of deinstitutionalization are viewed and discussed.The project has the following three objectives:1. To gain insight in the state of the art of deinstitutionalization in the participating countries and in professional and community attitudes regarding the soci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Joint training and research on Hedhehog-Gli signalling and its pharmacological modulation for regenerative medicine' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Debilitating degenerative diseases such as non-healing wounds and neurodegeneration do not yet have a cure. They represent a huge unmet medical need worldwide, especially in the aging European population. To reduce the incidence and improve recovery from such ephitelial diseases there is an major need to understand molecular signaling in order to promote stem cell behavior and enhance regeneration and healing. The key objectives of the HEALING network are 1) to train researchers in the fields of molecular signaling, developmental genetics, stem cell biology and small molecule chemistry; 2) to elucidate the mechanisms regulating one of the most promising pathways, Hedgehog-Gli (Hh-Gli) signaling; 3) to manipulate it by the development of specific small molecule agonists for future therapeutic use. Specifically, our research will (a) analyze the basic molecular mechanisms of Hh-Gli signaling in two model organisms and in human cells using leading technologies. In particular, (b) address the mechanisms that ensure controlled Hh-Gli function during skin wound healing and brain repair. (c) develop new small molecule Hh-Gli agonists for use as tools to be used as future therapeutics to enhance wound healing, regeneration and repair in a controlled manner. This network consists of 7 leading academic and research institutions, and 2 biotech companies from 8 European countries. It strengthens existing scientific collaboration, provides complementary expertise and brings together a critical mass for training and research. Additionally, it includes experts from Europe, Canada and Singapore, notably a pioneer in Hh-Gli signaling. HEALING will greatly enhance the training of the next generation of leading scientists in Hh-Gli signaling, stem cells and regenerative medicine. Thus, it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Raising Open and User-friendly Transparency-Enabling Technologies for Public Administrations'.

assistant: **Innovation**

ROUTE-TO-PA is a multidisciplinary innovation project, that, by combining expertise and research in the fields of e-government, computer science, learning science and economy, is aiming at improving the impact, towards citizens and within society, of ICT-based technology platforms for transparency. ROUTE-TO-PA envisions that Information and Communication Technologies for Transparency must improve the engagement of citizens by making them able to socially interact over open data, by forming or joining existing online communities that share common interest and discuss common issues of relevance to local policy, service delivery, and regulation; moreover, ROUTE-TO-PA aims at engaging citizens to a higher degree by providing a robust and more holistic understanding of transparency, by underpinning the next generation open-data based transparency initiatives, ensuring that published data are those of value to citizens, with a personalized view in different forms to different segments of the citizens and public based on their profiles for facilitate better understanding. ROUTE-TO-PA will deliver the experimented innovative and engaging ICT platforms to ensure citizen-friendly, conscious, and effective access to open-data, by offering easy understanding of, and social collaboration on, open data offered by PAs. The objectives of Route-To-PA are: (1) develop a Social Platform for Open Data (SPOD) enabling social interactions among open data users and between open data users and government data ; (2) build Transparency-Enhancing Toolset (TET) as extensions for existing major Open Data Platforms; and (3) develop a set of recommendations (GUIDE) as good practice guide for open data publishers for achieving higher quality transparency through open data. The objectives are deployed,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Environmentally COherent measures and interventions to debottleneck HUBS of the multimodal network favoured by seamless flow of goods' in the context of a Seventh Framework call.

assistant: **Objectives**

ECOHUBSprovides models and capabilities for cooperation and communication between green hubs’ stakeholders, plus establishing value added services making co-modal networks attractive to use and, at the same time, contributors to reduction in greenhouse gas emissions and other pollutants.The main outputs will be:1.Cooperative Model for Green Hubs enabling low-carbon, resource-efficient and secure transportation services2.Ecosystem for electronically connecting multimodal terminal network stakeholders and amplifying their joint capabilities when using the Cooperative Model. The result will be faster communications, shared resources and synchronised actions. An important focus will be integrating information obtained from on-going transport execution (visibility  of supply  chains) into planning processes (facilitated by hub operators) to ensure the best possible environmental and economic performance.3.Common Value Added Services to be combined with existing services, facilitating end-to-end co-modal, low-CO2 transport solutions that maximise utilisation of terminal and logistics resources. Common services will include: a. Intermodal terminal eco-efficiency calculator; b. Integrated competitive services for managing improvements in eco-efficiency; c. Measuring and Benchmarking System to provide the means of long term monitoring of greening activities and disseminating best practices at all supply chain levels and EU regions.4.Four ECOHUBSDemonstrators to be used across several representative operating scenarios characteristic of modern intermodal terminals.Special attention will be given to building improved understanding of prevailing complexities and business interests and ensuring long term sustainability of project outputs and market take-up based on an inclusive Stak
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Self-assembly of Carbon Nanotube junctions in Liquid Environments for Nanoelectronic Devices' in the context of a Fifth Framework call.

assistant: **Objectives**

Carbon Nanotubes will be functionalised by appropriate chemical groups in order to form binding sites, which can couple individual tubes in a liquid environment. The resulting tube networks will be attached to patterned substrates in order to fabricate demonstrator devices, which will be investigated by electrical transport measurements and scanning probe microscopy. Carbon Nanotubes will be functionalised by appropriate chemical groups in order to form binding sites, which can couple individual tubes in a liquid environment. The resulting tube networks will be attached to patterned substrates in order to fabricate demonstrator devices, which will be investigated by electrical transport measurements and scanning probe microscopy.OBJECTIVESUtilization of Carbon Nanotubes as active elements in electronic devices needs the ability to form well-defined electrical contacts between tubes and metallic leads as well as between individual tubes. Procedures for fabrication of single-walled nanotube networks connected by appropriate chemical linker molecules and electrical characterization will be the key goal. Binding organic linker molecules to the tube ends will modify tubes. By choosing appropriate complementary molecules we will form electronically active junctions, bridging individual nanotubes. Networks of tubes formed in this way will be attached to substrates in order to allow characterization of the transport properties across the junctions. Supported by theoretical studies, demonstrator devices will be fabricated which can be used as candidates for further optimisation.DESCRIPTION OF WORKSingle-walled Carbon Nanotubes will be synthesized by arc-discharge methods with a high yield and low defect concentration. Purification of the nanotubes will be done by established met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CAPITA: Child Abuse Prevention International Training and Access' (CAPITA) under Horizon 2020.

assistant: **Objectives**

This Proof of Concept proposal is a rare opportunity to translate social program innovation into international impact. Every year, a billion children worldwide are victims of child abuse. The highest rates are in  low-and-middle-income countries, affecting children of all ages (WHO, 2012). A small number of child abuse prevention programs for young children have been tested in high-income countries and commercialized. This makes them inaccessible to the vast majority of families at risk of abuse in the developing world.Since 2013, our ERC starter grant has aimed directly at innovation. Working with UNICEF and the WHO, we have developed and tested a 14-session, family-based child abuse prevention program specifically for low-income contexts, and for worldwide free availability: the ‘Sinovuyo Caring Families Program’New and robust scientific results have shown substantive reductions in child abuse for families participating in the program. There is already extensive demand for scale-up from policy partners, in over 16 countries in multiple regions. This proposal also presents extraordinary value-for-money, with co-funding for training and implementation already identified by agencies including USAID, Catholic Relief Services and governments in low-income countries.This grant would allow forming a strong and focused innovation team to provide the support needed by these partners for proof-of-concept scale-up in 16 initial countries. It will develop training, supervision and cultural adaptation guidelines. It will also support sustainable impacts through capacity-building a new non-profit entity being established by UNICEF and WHO to provide long-term management of the program scale-up.This proposal has potential for massive social impact: to reduce an acute social problem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Beasts to Craft: BioCodicology as a new approach to the study of parchment manuscripts'.

assistant: **Objectives**

The intention of Beasts to Craft (B2C) is to document the biological and craft records in parchment in order to reveal the entangled histories of animal improvement and parchment production in Europe from 500-1900 AD. B2C will lay the foundations for a new approach to the the study of parchment manuscripts —biocodicology— which draws evidence from the overlooked first stages in production, the raising of livestock and the preparation of the skins. 1. Parchment is an extraordinary but overlooked high resolution zooarchaeological record and a molecular archive. Livestock genetics is revealing breed diversity and markers of character traits such as fleece quality. B2C will exploit this new-found knowledge, using progressively older dated archival (sheep) parchments to study the history of improvement 1300 - 1900. Visual examination of the skins will search for direct evidence of disease and fleece quality. 2. Craft skills can be read from parchment and, when combined with chemical data and comparison with modern analogues, will produce the first European wide record of the craft from 500-1900. The size and scope of this the parchment archive means it is one of the largest and most highly resolved records of a specialist medieval craft. We will explore how these skills develop and when and where regional patterns appear and decline. These two remarkable records requires a large interdisciplinary team. However biocodicology draws from and informs upon a wide and diverse spectrum of existing scholarship in conservation, the arts and sciences. A third strand of the project will (i) furnish manuscript scholars with some of the information available to the scribe at time of production (ii) inform and shape attitudes to parchment conservation (iii) provide high resolution biologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A solar based, internally-illuminated bioreactor for microalgae cultivation' to be submitted under Horizon 2020.

assistant: **Abstract**

Microalgae can be of great benefit as a food source, as a natural source for a wide range of products and as biomass for production of biofuels as they can replace synthetic and/or fossil biomass, but they are far from reaching their commercial potential, because their cultivation is expensive and inefficient, limiting their use to high-value markets. An important product derived from microalgae is naturally produced Astaxanthin that can replace the current synthetically produced Astaxanthin used in salmon feed. For health reasons, consumers and regulators have started demanding replacing synthetic sources of Astaxanthin by natural sources.Brevel has created a novel microalgae cultivation system based on an internally illuminated photo bioreactor. Our system allows for microalgae production to become affordable and enables the stable cultivation of microalgae at a high capacity and resource efficient method. The unique approach lies in the internal volumetric illumination by concentrating and transporting sunlight by optical fibers. Brevel Ltd. was founded by three brothers in 2016 whose background is in microalgae production, physics and healthcare. The company is owned by the founders who invested €350,000 of their own savings as seed funding.Whilst the total market size for microalgae is almost €3 billion, we will first target the Astaxanthin market that had a €600 million size in 2016. Over 90% of this is manufactured synthetically due to the lower production cost. We would be the first to be able to compete with the synthetic alternative with natural Astaxanthin, which would greatly profit EU consumers who have access to eat healthier salmon. With the Phase 1 project, we want to study the feasibility of creating a small-scale and then large-scale production plant (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Agents of Logistics and Infrastructure in Eighteenth Century Alpine Transit Traffic' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

ALPINNKONNECT centres on operating trans-European commercial traffic as engine and manifestation of eighteenth-century prosperity. The project focuses on the interplay of agents, material prerequisites and natural impacts along main Alpine transit routes, applying an approach of socio-material-natural interconnectedness. It advances the hypothesis that transportation required a broad participation to cope with the enormous efforts and provided an important source of income. Hence, seen through the lens of transit traffic, new light will be shed on local social fabrics. Among the key figures, ALPine INNKeepers acted as cONNECTing agents and inns operated as multipurpose hubs of transit traffic. Considering the fundamental importance of transit traffic, the fragmented and dated state of research is striking. ALPINNKONNECT breaks new ground by adopting approaches of New Materialism and a relational concept of logistics and infrastructure, focusing on innkeepers, hauliers, carters, raftsmen, muleteers and rod cooperatives as protagonists and integrating households, marriage, kinship, property and gender as factors in this economic key sector. The main goal is to arrive at a comprehensive and empirically verified understanding of the preconditions, processes, implications and dynamics of transit traffic and its changes. ALPINKONNECT argues that transit routes remained vital during the eighteenth century, not despite, but complementary to, the economic rise of north-western Europe and its maritime traffic. The principal research question is: how did the interplay between the different agents, the built materiality and Alpine nature work? How did the flows of goods, which accounted for a significant share of the early modern European economy, cross the continent on Alpine rout