RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Pathways Regulating Intramyocellular Insulin Sensitivity and Metabolism in Health and Disease'.

assistant: **Innovation**

Currently, there is an urgent need to understand the pathogenesis underpinning insulin resistance (IR) and type 2 diabetes (T2DM), due to their dramatically increasing prevalence. Glucocorticoids (GCs) are potent modulators of skeletal (Sk) muscle insulin sensitivity, as exemplified in patients with GC excess, Cushing’s syndrome, who develop IR and T2DM. Importantly, increased GC generation locally in muscle may contribute to the phenotype in T2DM patients. Although the precise molecular mechanisms driving IR in both T2DM and Cushing’s syndrome are unclear, dysregulated lipid metabolism is a common feature of insulin resistant muscle. This proposal aims to identify how GCs regulate intramyocellular lipid metabolism, and how this impacts on muscle insulin sensitivity. In addition, we will test a novel therapeutic target involved in mediating the metabolic actions of GCs, recently described by Dr Carolyn Cummins, the supervisor of the outgoing phase of this proposal. The complementary expertise in integrative molecular physiology of Dr Cummins, and of the Experienced Researcher, Dr Stuart Morgan, dovetail nicely within an established multi-disciplinary collaborative network of pharmacologists, molecular biologists and analytical chemists at the University of Toronto that have a unifying goal to uncover novel mechanisms regulating IR. Specifically, this proposal employs a systems approach by integrating both in vivo and in vitro pharmacological and genetic manipulation, with lipidomic/proteomic profiling and in-depth molecular characterisations. This novel strategy will significantly advance our understanding of key processes regulating insulin sensitivity in Sk muscle, a process essential for normal glucose homeostasis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The role of a nuclear expression site in the regulation of virulence genes in malaria parasites'.

assistant: **Concept**

The deadliest form of human malaria is caused by the protozoan parasite, Plasmodium falciparum, which annually infects millions worldwide. The virulence of P. falciparum is attributed to its ability to evade the human immune system, by modifying the host red blood cell surface to adhere to the vascular endothelium and to undergo antigenic variation. The main cell surface ligands responsible for both cytoadherence and antigenic variation are members of the P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1) family. These polymorphic proteins are encoded by a multi-copy gene family called var. Each individual parasite expresses a single var gene at a time, whereas the remaining ~60 var genes found in its genome are maintained in a transcriptionally silent state. Switches in PfEMP1 expression allow the parasite to avoid the human immune response and maintain a long-term infection. The regulation of var gene expression is therefore responsible for both immune evasion and the pathogenicity of the disease. Mutually exclusive expression and antigenic switching of var genes is epigenetically regulated at the level of transcription. This was recently demonstrated to involve chromatin modification, subnuclear localization, promoter/promoter interactions, and sterile RNAs. However, our understanding of the molecular mechanisms by which var genes are regulated is still elusive, particularly the aspects of var gene activation. I hypothesize that there exists a specific subnuclear var expression site that is involved in var gene activation. To this end the goals of the proposed research are: 1) to determine the capacity of the postulated var expression site and its role in var gene expression; 2) to determine the specificity of the expression site as a limiting factor for var gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Industrial Doctorate Training Network on Future Wireless Connected and Automated Industry enabled by 5G'.

assistant: **Objectives**

The transition into the 4th industrial revolution promises to integrate IoT and cyber-physical systems into the industrial domain and to boost the productivity of industrial verticals thanks to a radical automation of all the phases of production. Communications are key to enable i4.0, but are subject to the stringent requirements of automated applications in terms of availability, reliability, low latency, integrity, scalability, safety and positioning accuracy. A wirelessly connected factory enables novel mobile robots, easy reconfiguration of assembly lines and migration of embedded control functions to the virtually infinite computational/cache resources and flexibility of edge clouds. From a managerial perspective, integrated billing and tracking capabilities of 5G facilitate novel models such as that can drive a business disruption. As a result, the i4.0 ecosystem is an opportunity for the wireless community and has become one of the key targets of 5G. From a technical side, the development of wireless i4.0 entails a paradigm shift from reactive and centralized networks towards massive, ultra-reliable and proactive networks that may operate in wide remote scenarios, with thousands of devices, uncertainty, high dynamics, rare events, unpredictable interference and harsh conditions. Merging 5G networks and i4.0 comes with its own difficulties, because these two domains have been disjoint so far. Here is the key opening identified by 5GSmartFact: the need of a surge of skilled researchers and engineers in the upcoming years to work at the crossroads of factory automation and 5G evolutions. Having this in mind, the objective of the research programme is to train young researches to be able to analyse, design, develop and assess the deployment of 5G networks that targe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'UWB wearable apparatus for bone fracture imaging and recovering monitoring' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Global changes in healthcare funding, an increasingly ageing demographic, explosions of new technologies are converging to transform our relationship with healthcare. Breakthrough innovations formed outside traditional healthcare industries are needed to change business models, reshape the future for better health outcomes and value for consumer. Thus, research on novel diagnostic and monitoring imaging modalities is essential. UWB imaging has recently emerged as one of the most promising non-invasive imaging modalities of the last two decades. Its low cost, non-ionising characteristics justify the considerable interest of the scientific community.  Extension of microwave imaging to bone fracture assessment is one goal of WEBOING proposal. In this contest, the design of UWB wearable apparatus for bone fracture imaging and recovering monitoring will allow to perform imaging without exposing patients to dangerous X-rays. The portable nature of the apparatus, will allows its use in site of accidents. In fact, simple microwave antennas coupled with a laptop-integrated Vector Network Analyser (VNA) are required, giving the methodology simplicity in manufacturing and a very a low cost; this aspect is even more significant if related to conventional techniques. Imaging of the bone fracture will be performed for the first time by appropriately reconstructing the electromagnetic field at UWB frequencies. Electromagnetic field reconstruction will be performed combining Modes concept and Huygens principle, which represents a new and unconventional procedure. Moreover, the same UWB antennas will also allow fracture recovering monitoring; in fact, by embedding the antennas in the plaster cast, it will be possible to perform bone imaging on periodic base without having to remove the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'User-oriented, secure, trustful & decentralised social media' (EUNOMIA).

assistant: **Innovation**

EUNOMIA is a fully decentralised, intermediary-free and open-source solution for addressing three key challenges: which social media user is the original source of a piece of information; how this information has spread and been modified in an information cascade; and how likely it is to be trustworthy. Although its innovations are applicable across any social network, its design philosophy makes it ideal for evaluation on similarly open, decentralised and federated new social media networks, thus contributing against accumulation of power in the large social media intermediaries located outside Europe. EUNOMIA actively encourages democratic citizen participation in content verification by allowing voting on content trustworthiness and influencing the reputation of content generators and sharers. It combines information cascade verification with information trustworthiness scoring, benefitting from blockchain technology to ensure transparency of the scoring process and that information has not been modified in a cascade. It also places emphasis on ensuring that trustworthiness information is communicated transparently and accessibly. A General Data Protection Regulation (GDPR) compliant and ethically responsible digital companion running as a local app on the user’s device encourages the involvement of each user, while also carrying out the background processing for scoring and verifying content, and crucially for visualizing to the user. EUNOMIA uses social-science based co-design methodologies acknowledging and integrating users’ experiences of social media, specifically in how they use and trust the information they interact with. EUNOMIA’s versatility will be evaluated with large communities in social journalism and traditional media, as well as the largest user com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mechanistic Studies of Catalytic Activity in Electrochemical CO2 Reduction Reaction by Operando Surface Enhanced Raman Spectroscopy Coupled with Electrochemical Mass Spectrometry' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Wide-spread application of fossil fuels by humankind during a few past decades has resulted in increased concentration of carbon dioxide (CO2) in atmosphere from approximately 270 to more than 400 ppm during the past 200 years. The increased CO2 level in atmosphere causes unprecedented raise of the earth’s temperature and acidification of the oceans. Therefore, there is an urge to reduce the devastating consequences of global warming, as highlighted in the global summit on climate change (Paris Agreement) as well as the European Commission. Replacing the conventional fossil fuels with renewable sources of energy has been recognized as one of the crucial actions in this regard. Accordingly, conversion of CO2 into other carbonaceous fuels may decrease the CO2 concentration in atmosphere, while producing a renewable source of energy. Electrochemical reduction of CO2 provides high environmental compatibility and adaptability with renewable forms of energies like wind and solar. Electrochemical reduction of CO2 to fuels reverses the combustion, facilitating the storage of electricity by CO2 reduction reaction (CO2RR) to form valued hydrocarbons and oxygenates. Despite the recent progresses in catalysts design, the complex mechanism leading to formation of a mixture of 16 different products on various surfaces is not thoroughly understood. New operando spectroscopic techniques are required to illustrate the underneath reaction mechanism through tracing the intermediates species. Accordingly, the objective of this project is to develop an operando technique by coupling surface enhanced Raman spectroscopy (ESRS) with electrochemical mass spectrometry (EMS) for CO2RR mechanistic studies. The obtained insights from this study will determine the mechanism of catalytic activity in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Towards positional cloning of the autosomal dominant sacral agenesis and darier's disease genes' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The research objectives are two-fold: 1. To conduct genetic and physical mapping in the 7q36 region in DNA samples from patients and families with autosomal dominant sacral agenesis. This disorder was first localised to the 7q36 region last year by Professor Strachan's group, and the critical region containing the gene is still several Mb long I plan to conduct further mapping in these families in order to help narrow the location of the gene, and thereby facilitate future positional cloning/positional candidate gene approaches to identify the gene. 2. To isolate and characterise novel genes in the Darier's disease region at 12q24.1. This disorder was simultaneously mapped by Professor Strachan's group and a group from Cardiff in 1993. Since then Professor Strachan has been able to narrow the location of the gene to an interval of about 2Mb which appears to be gene-rich and which contains unidentified genes for some other disorders, notably spino- cerebellar ataxia type 2. I plan to identify novel genes in this region by comparative mapping between human and pufferfish, to characterise selected genes and in promising cases, test for patient-specific mutations. Training content (objective, benefit and expected impact) The project is intended to provide a comprehensive training in human gene mapping and gene identification. The autosomal dominant sacral agenesis project is designed to provide experience of basic genetic and physical mapping whereas the Darier's disease component will provide expertise in more advanced technologies based on identifying and characterising genes in cosmids and PAC clones. In addition to providing a wealth of valuable expertise in human molecular genetics, the host institution offers excellent research faciliti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Smart Digital Library of Edutainment by Smile and Learn'.

assistant: **Objectives**

Children spend many hours using technology. Parents are concerned about having their children using new technologies without adequate educational resources. To resolve this need, Smile and Learn places technology at the service of education with the mission of helping children 2 to 12 years old learn while having fun using technology. We use games, interactive stories and technology to help educate children in universal values, learn curriculum contents and reinforce their multiple intelligences.We are developing one single Smart Digital Library of Edutainment that gives access to +100 individual proprietary apps, offering clients a smart recommendation model based on children’s performance and that is already a reality with 18 apps on the market with great acceptance (+200,000 downloads). It is based on:• 100% proprietary customized content based on S&L’s educational framework.• Smart recommendation model based on children’s interaction, leveraging big data analysis, machine learning and collaborative filtering. • Mobile, multi-device, multi-platform and child-safe.Global mobile market for education and entertainment for children will grow from €12B to €26B from 2014 to 2020. The market is currently highly fragmented and has no global winners. The opportunity for an approach that truly combines entertainment and education is clear. Our goal is to lead this white space worldwide. Our goals for the coming months through the H2020 program are to finish the Smart Library’s integration and testing, run on site market studies focusing on Spain as our pilot market and adapt the business model’s development to the pilot’s results.Our project is framed within the global education challenge. We will finish phase I before June 2016. Once all tasks are finished, we will update the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Safe, ClimAte Resilient Infrastructure' (SAFARI).

assistant: **Innovation**

SAFARIs project aims to develop a generic digital platform for resilient port infrastructure, connected to large port communities, facing extreme weather events, with emergency management modules fed by operational, maintenance and analytical modules. The implementation of the SAFARI project will allow to: Maintain the port operation at 80% of capacity during the disruption periods; Optimize the allocation of multi-modal transport assets before and after the disrupting event to reach 20% of modal cargo shift with less environmental footprint and to minimize the downtime during extreme weather events; Develop resilience measures to strengthen existing port infrastructure against extreme weather events. Ensure the safety of personnel, vessels and protect the biodiversity; Build a governance model and guidelines to address climate risks and hazards for port infrastructure.The SAFARI consortium aims to deploy new measures reaching a TRL 7 by the end of the project in different maritime and inland infrastructures of port partners, from North Sea, Atlantic Ocean and Mediterranean Sea, that can minimize the impacts of the disturbances issued from the extreme weather events. Three pilot demonstrators are selected from the littorals of Europe, namely Port of Dunkirk (FR), Port of Seville (ES) and Port of Lisbon (PT).


**Keywords:** Port capacity, model shift, bio-diversity, extreme weather events, large scale digital platform, maintenance, safety
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'VALIDATION OF LASER WELDING TECHNOLOGY FOR HEAVY SECTION COMPONENTS', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Industry requests for quality improvement, costs reduction and more strict scheduling results in an increasing demand for automation. This project, based on the combination of an innovative Laser Beam welding process, with the capabilities of Heavy Robotics, was structured to satisfy these needs, taking into account several requirements, from the configuration/design of welded components to friendly system management, with the opportunity of efficient interface with operators, as well as fully automated processing and monitoring. The proposed welding technique has a very large field of applications in welding heavy section components (10-25 mm in thickness) in the energy, electromechanical, petrochemical, construction, transportation and shipbuilding industries.The main goal of the project was dissemination of the technology by means of an effective demonstration of system integrability in a production environment, based on the following:- feasibility of the laser welding process, remotely carried out, on heavy section components- exploitation of advantages related to the laser welding technique, applying new design criteria- development of procedures for the integration of subsystems at HW and SW level- demonstration of system industrial functionality and user friendly automation standards.The expected advantages were linked to positive effects on costs and design including- optimisation of subcomponents thickness, with adequate design criteria and simplified standards- reduction of component distortions as well as of post-welding operations- higher process reliability due to the use of sensor based robotics tools.- increased diffusion of laser welded solutions.