RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flexible Superheated Steam Torrefaction and Grinding of Indigenous Biomass from Remote Rural Sources to Produce Stable Densified Feedstocks for Chemical and Energy Applications' under Horizon 2020.

assistant: **Concept**

The objective of SteamBio is to demonstrate a mobile processing concept that will enable efficient pre-treatment of agro-forestry residues for use as flexible feedstocks in chemical and process industries. These ligno-cellulosic materials originated from rural locations will be upgraded and densified into uniform sizes at source, allowing cost-effective transportation to existing industrial sites. The core enabling technology is superheated steam processing (SHS). SHS has been implemented in diverse drying applications at industrial scales, due to its superior heat transfer properties. At pilot scales, SHS has been proven to torrefy biomass at temperatures up to 300°C with minimal ligno-cellulose breakdown. Unlike conventional torrefaction techniques, which use flue gases as heating medium, it does not contaminate the torrefied biomass and volatile fractions, allowing economic recovery of chemicals. Moreover, it is also readily scalable for continuous operation. In SteamBio, a transportable demonstrator unit will be operated at five different rural locations where it will be used to torrefy tonnage quantities of six different agro-forestry residues at a throughput of 500 kg/h. The demonstrator unit will be operated at these rural locations throughout the last twelve months of the project to allow for seasonal fluctuations in the composition of the materials being valorised. The torrefied biomass fractions (solid and liberated volatiles) will then be validated as green building blocks in commercially relevant chemical production and in bioenergy use. Life cycle experts will validate that SteamBio will have positive environmental impacts. A robust business strategy will be developed to enable the results to cross the ""valley of death"" post-project and to ensure widespre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ARGONAUT: from the synthesis of gAnglioside tumouR antiGens to a platfOrm for caNcer Active immUnoTherapy' (ARGONAUT).

assistant: **Concept**

Immunotherapy is currently revolutionizing cancer therapy by harnessing the power of the innate and adaptive immune system against cancer cells, thus providing a more tumour-selective approach in assistance to traditional treatments. The identification of tumour-associated carbohydrate antigens (TACAs), aberrant types of glycans decorating the surface of tumour cells, has paved the way for the development of new types of cancer vaccines. However, while significant progress has been made in this area of research, TACA-based cancer vaccines have not yet reached the clinic. In this context, ARGONAUT will address some limitations that characterize classical approaches in carbohydrate cancer vaccine development, with the overall aim of establishing a strategy to access novel, more effective, and fully synthetic vaccine candidates. ARGONAUT’s journey aims at the preparation of vaccine candidates based on ganglioside-type TACAs (expressed in melanoma, neuroblastoma, and small cell lung cancer) that are easy to formulate, able to elicit a immune response independent from individual polymorphisms, and with better chances to reach the clinical environment. Employing a synthetic carbohydrate chemistry approach, ARGONAUT explores its application as a tool to contribute to H2020 European efforts in cancer research, while providing excellent training in a multidisciplinary and intersectoral environment through a well-implemented work-plan. From another perspective, ARGONAUT’s impact will also benefit from the transfer of knowledge to the host institution with the establishment of a new research line in active cancer immunotherapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The post-copulatory interplay between females and ejaculates in social insects'.

assistant: **Objectives**

The hymenopteran eusocial insects (ants, bees, wasps) not only have impressive colony lives, but also spectacular adaptations for the years-long storage of live sperm. Where human medicine requires cryotechnology to do this, the queens of honeybees and ants produce glandular secretions to maintain sperm at ambient temperatures inside a specialized storage organ (spermatheca). During my PhD, I pioneered the study of male accessory glands and their effects on sperm viability during insemination, using mostly leafcutter ants. I discovered that ejaculate competition has evolved in ants and bees with multiply mated queens, but is terminated by ant queens after sperm storage. This made it clear that female secretions play key roles and that proteomic approaches are needed to understand their function. I plan to use the honeybee Apis mellifera to study the effects of female glandular secretions in situations of potential sexual conflict. These arise when queens are inseminated by multiple males and have an interest in selecting the most viable sperm fraction for permanent storage and later use when fertilizing eggs. I will combine evolutionary biology with proteomics technology to characterize and identify the proteome of secretions that newly mated queens add to ejaculates while sperm is transferred, maintained in the reproductive tract for up to several days, and finally stored for years. I will also study the specific effects of oviduct- and spermatheca secretions on ejaculate physiology and sperm viability. Finally, I will combine biochemical and experimental approaches to clarify the function of specific protein components within these female secretions. My research will provide novel answers to general evolutionary questions about the expression and regulation of sexual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification of chemicals in edible fish containing microplastics as potential source for human exposure' under Horizon Europe.

assistant: **Concept**

Microplastics (MPs) are extremely persistent, ubiquitous and have the ability to adsorb/absorb chemicals from the surrounding environment. Marine organisms ingest microplastics and the chemicals are transferred through the food chain, and may potentially reach humans through the consumption of fish and shellfish.  Therefore, the identification of chemicals arising from this potential  human exposure source is of great interest for ensuring food safety and establishing the appropriate legislative framework. FishConPlastic proposes a simple and robust methodology, based on the combination of supramolecular solvents (SUPRASs) with liquid chromatography-high resolution mass spectrometry (LC-HRMS), that will allow to detect and identify chemicals associated with the intake of microplastics in edible marine species through suspect and non-target analysis. FishConPlastic will provide the first overview on chemical-microplastic contamination in edible marine species from the Mediterranean Sea. In a second stage, the relationship between the chemical present in marine organisms and the microplastics will be investigated. For this, the quantity, size, integrity and polymer-type of the microplastics found in the marine species analysed will be determined. Finally, all the identified chemicals will be prioritised in a list according to the level of confidence of the identification, frequency of detection, human risk exposure to chemicals and toxicity. FishConPlastic will offer to public authorities a comprehensive list of chemicals to be monitored for ensuring food safety, which is expected to have a positive impact on  net fishery exports in the European Community. FishConPlastic is in line with the European Mission on healthy oceans, seas, coastal and inland waters, deepening the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Forging Ahead: Faking Sagas and Developing Concepts of Cultural Authenticity and National Identity in 17th- and 18th-Century Scandinavia', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The high-stakes game of forgery, from priceless art to counterfeit banknotes, has stimulated public and professional interest for centuries. This project adds to the body of relevant examples, and feeds back into the broader theoretical frameworks, by looking at a number of texts which appeared for the first time in 17th- and 18th-century Scandinavia and were revealed to be forgeries. The most famous (although still relatively unknown) are ‘Hjalmars och Hramers saga', ‘Krembre saga' and ‘Hafgeirs saga Flateyings'. Since their appearance very little research has been done on these works: as literary forgeries they are deemed to have little value in the intellectual and literary history of Scandinavia. This project will prove, on the contrary, that these texts play a central role in the development of literary and philological studies in the region. Moreover, their very existence problematises many of the basic concepts employed by researchers of Scandinavian texts: fiction, history, philology, textual unity, authorial intention and not least national identity. While the overall aim of the project is to bring the importance of these forgeries to light, this will be carried out through three subsidiary aims: 1) Studying the interconnectedness of philological developments with developments in forgery. As forgers develop new techniques, philologists do so too in order to expose fakes, but these dialectical movements are not just opposites, but may also involve a blurring of techniques and aims. 2) Looking into the ways in which international trends have fed into Scandinavian forgery, taking classical and renaissance cases of forgery and forgery exposure as well as enlightenment and romantic causes celebres. 3) Analysing forgery as national fantasy, by using the ideosyncrasie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bugs as Drugs: Understanding Microbial Interaction Networks to Prevent and Treat Infections' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Our body is inhabited by an enormous number of microbes which are crucial for our health. The bacteria in our gut for example help us to digest food but can also make us sick in case of an infection. The overall composition and function of those communities are strongly shaped by the interactions of the microbes within them e.g. how the microbes influence each others growth. These interactions are especially important in the case of microbial infections. Since pathogens have to interact with the microbial communities that already inhabit the host, the native microbes can repel or support the pathogens and thus protect the host from diseases or even facilitate them. Although microbial assemblages are pivotal for our health we have currently no satisfying way to get a mechanistic understanding of them which would be crucial to specifically manipulate these communities e.g. for therapeutic interventions. The aim of this proposal is to develop a microscopy method that allows to obtain interaction networks within complex communities. Since bacteria can only share the same space if they tolerate each other but avoid each other in case of competition, interaction networks of complex communities can be derived from the spatial co-occurence of the bacteria that form them. With this technology I especially want to investigate how pathogens embed into the native gut microbial community of the model organism Caenorhabditis elegans. I want to understand how interactions between pathogens and native gut microbiota can protect a host from infections. Finally, I want to use this technology to identify bacteria in the native gut community that can outcompete pathogens and work as specific probiotic against microbial infections. This approach could revolutionize the usage of probiotics a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Water quality biomonitoring combining AI and environmental genomics'.

assistant: **Objectives**

The impact of human activities on the environment is regularly monitored by environmental agencies and by the industry. This trend is growing due to public recognition of environmental threats and pressure for transparency as well as more stringent regulations tackling water pollution. ID-gene goal is to provide environmental agencies and industry that cannot respond to the growing demand for environmental impact assessments with fast, sensitive and reliable eDNA tests/assays for species detection and bio-indication. Founded with the idea of applying environmental genetics to environmental impact assessments and developing new technological solutions, ID-Gene is implementing customer-focused approach. Time is spent on listening to customers making sure that their needs are thoroughly understood and brainstorming possible solutions.A spin-off of the University of Geneva, ID-Gene services are certified by the Aquaculture Stewardship Council (ASC) for the environmental impact assessment of salmon farms. The company developed & led the €1.3 million SYNAQUA project for the development of eco-genomic tools & is involved in international projects enforcing environmental genomics for biodiversity monitoring. ID-Gene is also involved in the DNAqua.net COST action, being considered an expert in the field of eDNA for water quality monitoring. ID-Gene technology on water quality monitoring has been field tested since 2015 onward, with field trials in over 400 sites, with continuous testing taking place as the technology development.ID-Gene possesses a state-of-the-art laboratory, controlling all steps of the analysis, from eDNA sampling to high-throughput sequencing & sequencing data analysis with well-established and customs tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The genomic basis of convergent evolution in modern sloths (Xenarthra, Mammalia)' (CONVGENOMS) under Horizon 2020.

assistant: **Objectives**

At the end of the Pleistocene mass extinctions of the mega-fauna occurred worldwide, in particular in the Americas. Following the last glacial period, mammoths, mastodonts, giant sloths and other large mammals succumbed until extinction (about 10,000 years ago). While some Orders within Mammalia lost a couple of species, the sloths (Folivora, Xenarthra) clade has virtually lost all its diversity, gaining a status of a nearly-extinct suborder. Only two out of the close to 100 genera estimated to have existed survived to the mass extinctions to this date, named Bradypus and Choloepus. In contrast to their giant relatives, the modern sloths are medium-sized animals that developed a very specialized feature: obligatory arboreal suspensory behaviour. Their surprisingly high number of superficial similarities were acquired in parallel – since both genera are completely unrelated, and probably diverged ~30 Mya – and represent an amazing example of convergent evolution. In the current Genomics era, we are finally at a point in which full genomes can be assembled for non-model organisms at reasonable costs, bringing unprecedented opportunities for new studies on elementary questions on evolution. Here we propose to study the genomic signs of convergent evolution leading to obligatory suspensory locomotion and low metabolic rate on a comparative genomic analysis including 4 whole genome sloth sequences, three of which will be sequenced and assembled within this study. The Experienced Researcher masters all the bioinformatics expertise to complete the genomes. The host institution offers all the infrastructure and hypothesis thinking to successfully finalize the project. Jointly this team can push the boundaries of biological knowledge beyond, which will help the applicant to matu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Polymer Microarrays – Identification of Substrates for Cellular Control and Enrichment' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Summary: Over the past decade the Bradley group has developed a variety of sophisticated high-throughput approaches for the preparation/fabrication of polymer microarray platforms (with arrays of several thousand individual polymers printed onto standard microscope glass slides and their subsequent biological screening and evaluation. Thus slides can be interrogated with a variety of cells (mammalian, bacterial or even parasites) with subsequent high-content screening, allowing the identification of a specific polymer or polymer blend that binds or otherwise modulates cellular function. This platform allows polymers to be rapidly identified, as novel substrates, which can bind cells in a selective manner, allows proliferation of defined cell populations and control cell fate, while offering the possibility of identifying defined synthetic matrices that might replace animal derived substrates like gelatine or collagen or discovering materials that can be coated onto mesh and used in filtration devices. Using this approach the Bradley group have discovered a variety of new materials, three of which are now undergoing in vivo evaluation and two are undergoing commercialization (as well as delineating their modes of action). They are currently collaborating with over twenty research groups using this technology and have published extensively. This forms the ethos of this proposal and opens a door on broad numbers of EU priority areas. No other group in the EU is working on such a far reaching polymer discovery strategy or has discovered such a plethora of novel polymers for such a range of practical applications. It is in this area that I wish to immerse myself, while bringing my own skills associated with polymer chemistry and application in the area of drug release.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Active nonlinear mirror for all-optical time division multiplexing'.

assistant: **Objectives**

The aim of the present project is the study, design and realisation of an all-optical active nonlinear mirror (ANLM), to be used for all-optical time division demultiplexing and possibly in other all-optical processes. This device will be based on the nonlinear interaction between two optical beams, one of them with a frequency twice that of the other beam, at the surface and/or at the bulk of a second-order nonlinear material structure. These two beams will correspond to the control and signal waves, respectively, that are involved in a demultiplexing operation. In our case, the second harmonic beam will be used to control the reflectivity of the device for the signal beam, allowing in this way appropriate routing of that later beam. The instantaneous character of the second-order nonlinear optical interaction should allow to eliminate the considerable slow-down driving signal manipulation inherent to presently operative methods requiring transformation of the optical signal into an electric signal.The approach to achieve this goal is the following. In a first phase, of duration nine months, we plan to theoretically and experimentally demonstrate the phenomenon of controllable (active) nonlinear reflection in two simple material structures, in which the phenomenon occurs either at the surface of the nonlinear material (objective1) or in the bulk of the material when it is placed inside an optical cavity (objective 2). Next, and taking into account the results obtained in the objectives 1 and 2, we plan to identify the most appropriate type of material configuration to achieve (in the second phase of the project) the ANLM, giving sufficient evidence that the efficiency and characteristics expected for the final device will be appropriate for application in all-optical i