RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Calcium release and calcium influx during cell-cycle' (1994-1998).

assistant: **Innovation**

Research objectives and content Progression through the cell-cycle is regulated at key checkpoints by a rise in cytosolic calcium. Abnormalities in calcium signalling can give rise to uncontrolled cell growth, resulting in cancer. In non-excitable cells, calcium can be elevated either by release from IP3-sensitive intracellular pools or through the store-operated calcium entry pathway (ICRAC)- However, the properties of both calcium release and ICRAC during different stages of the cell-cycle have not been investigated. Using electrophysiological (patch-clamp) and optical techniques (calcium imaging) experiments therefore will be designed to address how calcium release and entry change during the cell-cycle. ICRAC is extensively regulated by cytosolic processes, and the cell-cycle dependence of this regulation will be investigated. Finally, experiments will be carried out to examine the cell-cycle-dependent expression of potassium channels, since these channels maintain a large electrical driving force for calcium influx. Elucidation of these processes is important not only for a more complete understanding of cell-cycle events, but also opens up new areas for pharmacological treatment of human diseases like certain cancers. Training content (objective, benefit and expected impact) During my stay in Oxford I will learn the powerful method of high resolution digital calcium imaging which will be of fundamental benefit in my future research. I will also focus extensively on ICRAC, and will gain invaluable experience in measuring this important, but small, calcium current. Dr. Parekh's lab. is one of the few in europe that is technically able to reliably measure this current, and he has much experience in the ICRAC field, having worked on it for several years. I also will l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Improving the quality of cultivated scallops to ensure a viable aquaculture production'.

assistant: **Innovation**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe main objective of the project is to increase the European production of the great scallop, Pecten maximus. The scallop is a highly valued seafood product on the European seafood market. There are about 20 species of commercially exploited or cultivated species world wide, and of these the great scallop is one of the most sought after. The EC market for scallops is strongly dependent on import from overseas areas. In 1997 the EC imported more than 20.000 tons (meat weight) of fresh, frozen and chilled scallops to a value in excess of 180 million ECU.The supply from EC countries is dominated by fishery (30.000 tons raw weight), while on a world scale the production of scallops is dominated by aquaculture (> 70%). Increased EC production from aquaculture will greatly enhance the supply of high quality live and fresh scallops to the market. Currently most of the European scallop production is dredged or diver harvested, but aquaculture production is increasing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Kick-starting global cLimate Investments: uncovering hidden liNks in climate finance and exploring dynamic evolution of investment networKs for policy deSign' (LINKS) under Horizon 2020.

assistant: **Objectives**

LINKS aims to contribute to a transformation of the climate finance system to deliver the scale and quality of investment needed to meet the Paris climate goals and ensure effective capital allocation. By understanding the architecture of the financial system, exploring macro patterns in low-carbon investment emerging from observed investors’ behaviour and interactions, and designing cross-cutting policies aligned with long-term climate targets, LINKS will promote essential guidance for a re-orientation of financial flows towards low-carbon and energy efficiency investments. LINKS aims to advance the understanding of the role of climate finance to foster the low-carbon transition by using network theory, advanced computational techniques and extensive empirical data to model the financial system as a complex adaptive system. LINKS will thus lay the foundations of, and pioneer a new field, namely climate finance networks, where dynamics of interconnected investors represented as a network, results in the complex behavior of the whole system. LINKS will bring together interdisciplinary theories and developments in finance, environmental economics, sociology, computer science, network analysis and complexity in an integrated approach to study and model climate finance. Taking this approach will allow advancements in at least three directions: i) a new theoretical approach to account for complexity thinking and systemic perspective in climate finance, ii) more empirical analyses on networks structures of low-carbon investments and their dynamics to shape the development of the climate finance system, iii) policy modelling analyses to explore whether specific architectures of the climate finance system have significant impact on the effectiveness of climate public policies a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Global social work and human mobility: comparative studies on local government and good social work practices in the euro-mediterranean region' to be submitted under Horizon 2020.

assistant: **Abstract**

This project main objective is to consolidate an international and inter-sectorial network of comparative and collaborative research and training on the identification, analysis and dissemination of good practices in the field of social work and human mobility in the European countries involved in the project, including universities, local town halls and third sector organizations. The reception and socioeconomic inclusion of migrants and refugees are key issues for contemporary Europe, particularly in the Euro-Mediterranean region, where the magnitude of new arrivals arouse great human rights concern. Social work professionals are in the front line of this challenge, playing a key role in local government responses and professional practices for the reception and inclusion of newcomers. Experienced qualitative methodological approach used in migration studies and related to social work will be utilized mainly. The participants of this project will exchange skills and knowledge which will allow them to progress towards key advances in the identification, transfer and promotion of good practices on local government and social work interventions with migrants, refugees, asylum seekers and other groups in conditions of vulnerability as a result of human mobility (non-accompanied children and youth, the elderly, victims of human trafficking, the disabled, transnational families, victims of ethnic, religious and sexual orientation discrimination, etc). The methodological approach will combine secondments of senior and junior researchers and social work professionals, the implementation of comparative research, training workshops and activities to disseminate knowledge and promote good social work practice, such as international conferences, the elaboration of guidelines and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Surrogate modelling for 3D-printed, achromatic, high numerical aperture metafibres'.

assistant: **Objectives**

With the proposed research project, I aim to revolutionize optical metasurface design leveraging surrogate modelling techniques (OBJ1) towards the development of 3D-printed, achromatic, high numerical aperture (NA) metalens-enhanced fibres, called metafibres (OBJ2). The proposed methodology consists of three interconnected phases: firstly (WP1), constructing a supercell meta-atom library consisting of three-dimensional metaatoms through iterative optimization. The simulated designs will be 3D-printed and the simulation model updated based on the results of the experimental characterization, ensuring precise and realistic control of meta-atom responses. Secondly (WP2), a Gaussian Process Regression (GPR) will be implemented as a versatile surrogate model using the established supercell library. This machine learning technique enables the efficient prediction of complex optical meta supercell responses, facilitating rapid prototyping and customization with reduced computational overhead. Notably, GPR models allow to consider fabrication tolerances straight-forward in combination with data augmentation techniques. Lastly (WP3), I will exploit the GPR model for the design of high-performing achromatic metafibres, utilizing 3D-printing technology to directly print the metalenses on the tip of optical fibres.I have chosen a top research centre, Leibniz Institute of Photonic Technology/ Jena, Germany, to develop my MSCA project under supervision of a world-leading expert in optical fiber photonics. Using my knowledge in engineering, photonics and numerical simulation tools, this MSCA project will pave the way for metafibres promising  versatile and broadband optical solutions with the potential to transform fields like microscopy, telecommunications and medical imaging. This r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European training for young scientists and museum explainers' (DOTIK) targeting Sixth Framework.

assistant: **Abstract**

Ad- hoc participatory events are held by science museums and other institutions to stimulate the involvement of citizens in scientific debates and decisions. We believe that it is also crucial to create a more widespread fabric of participation, disseminating the culture of science/society dialogue in all informal learning contexts and activities of popularisation of science. Animators (explainers, educators, demonstrators or pilots) represent a very large group of players in the science/society dialogue. They are essential in museums, temporary exhibitions, science festivals and institutional activities such as open days, because they are the main interface between the container-institution (museums, research centres, universities) and its public, and thus often the only reliable source of feedback. They are in most cases undergraduate or PhD students in scientific disciplines, and thus will-be scientists. Through a two-years activity leading to a School of science communication, this project develops and tests methodologies for training Animators for a most effective science/society dialogue.The project is not intended to replace normal training, but to devise theoretical knowledge, evaluation techniques and new tools to enable Animators:1. to increase the dialogue between science and society in a day after day action2. to be involved in the evaluation practices of their institutions3. to act as ambassadors of public needs and concerns in the scientific institution where in many cases they will continue their career4. to be aware of sprit and practice of new participatory procedures.The first year is dedicated to planning and testing the scheme, involving a small group of Animators and exchanges of best practices among institutions; in the second year a School will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Microscale investigation of key bacterial phenotypes enhancing collection by rising bubbles and aerial dispersal' (BactoBubble), addressing dissemination and exploitation.

assistant: **Impact**

Aerial transport of microbes has fundamental consequences for microbial dispersal, disease spreading, and atmospheric phenomena. In the ocean, aerosolisation largely originates from collection of bacteria by rising bubbles, which burst at the surface and eject cells in microdroplets. This process underlies the enrichment of bacteria in aerosols. While we know that collection rates vary among bacterial species, we know little about the bacterial properties promoting collection, and even less about which factors drive enhanced collection of certain species.Combining state-of-the-art microfluidics and microscopy, I will provide the first microscopic observation of bubble-bacteria interaction, to investigate two hypotheses:H1: Cell motility increases microbial collection by rising bubbles.Motility sets bacteria starkly apart from inert particles, likely promoting collection by increasing encounter rates and changing surface properties. H2: Starvation increases microbial collection by rising bubbles.Starving bacteria modify their surface and size, which may enhance collection by bubbles, thereby promoting dispersal from nutrient poor areas.To investigate H1 and H2, I will develop a novel microfluidic flow channel containing a pinned bubble, and use advanced optical microscopy to quantify collection rates for a range of bacteria. Experiments using mutants to alter motility (H1) and varying starvation levels (H2) will be complemented by characterization of bacterial surface properties. I will also develop the first mathematical model predictive for microbial aerosolisation.This project builds on my experience in modeling and interfaces, enhanced by training in microfluidics and marine microbial ecology within an internationally recognised multidisciplinary group, in order to o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Toward an integrated network for pain management programmes in Europe' to be submitted under Sixth Framework.

assistant: **Abstract**

Improving pain management and providing equal access to pain relief for all European citizens is a major health concern in E U. Two national research programmes address this problem: French and Portuguese programmes,financed by the respective Ministries of health. Pain management is considered as a priority research domain in these countries and the national programmes aim at providing high quality health care services in the pain field in order to diminish the individual and socio-economic burden associated with pain, chronic pain is one of major costs of the health domain, comparable to that of cerebrovascular or cancer. In parallel, pain management is part of research programmes in other member states. The great imbalance between what is known on pain management and programmes setup across E.U. explains why such a big proportion of European citizens stillsuffers from acute pain during procedures or from chronic pam. Underestimation of pain is widespread acrossE.U. Well conducted national research programmes on pain management could solve most of these issues. All E.U. member stales face these common challenges to relief pain and there is no forum for reflection to implement common actions at European level. The objective of PAIN-ERA project is to overcome the current fragmentation, and in the frame of the strategic objectives of the ERA-NET scheme, to build the basis for a coordination action in the field of pain, in order to improve its overall managemenl and create a sustainable long-term cooperation between national/regional research programme makers. By regrouping specialised healthprofessionals, programme managers and policy makers working in pain management area, the PAIN-ERA project would help to prepare the ground for activities in an ERA-NET Coordination Act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular Dissection of Melanoma Progression: An integrated Pan-European Approach' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Transformed melanocytes use several strategies to enable their progression to advanced melanoma and metastasis, including genetic and epigenetic alterations, along with disruptions to gene and protein expression. This consortium aims to identify novel biomarkers for predicting the progression and prognosis of melanoma. To achieve this, a concerted collaborative effort is proposed here between key academic and industrial partners, centred on intersectorial training of experienced researchers. Our first goal is to identify novel methylated genes via several complementary screening methods, followed by validation extensive melanoma cohorts available to the consortium. We will use the following strategies to identify methylated genes: (1) an array-based technique called MeDIP-ON-CHIP, (2) a high-throughput bisulphite-based technique developed by Illumina (to simultaneously analyse up to 800 genes over 96 samples) and (3) in silico analysis of DNA microarray data. To validate these methylation targets, we will use both qualitative and quantitative methylation-specific PCR (MSP) and determine if these methylation events correlate with melanoma progression, i.e. from benign and atypical nevi to primary and metastatic tumours. Our second goal is to validate genes that associate with melanoma progression and prognosis. For this aspect of the project, we will concentrate on the application of tissue microarray technology and associated image analysis approaches to validate molecular determinants of melanoma progression. Prioritised targets will then be functionally validated by a unique in vitro assay that models extravasation, or exit of cancer cells out of the blood stream, a key step in the metastatic process. Overall, these studies will give clues to melanoma progression, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Trans-Atlantic coral ecosystem studies'.

assistant: **Objectives**

The TRACES proposal seeks funding for a two-year fellowship. The applicant has over ten years research experience and has worked on cold-water coral ecosystems since 1997.It is now clear that these ecosystems are widespread in the Atlantic Ocean where the y support high biodiversity and are significant archives of palaeo-climatic information. It is also clear that they have been damaged by bottom trawling and may be threatened by ocean acidification.However, the lack of unified ocean basin-scale studies of these deep-water ecosystems limits their use as palaeo-climatic archives, impedes our understanding of their significance as speciation centres and the paucity of information on their ecological connectivity limits the scientific basis for the design of marine protected areas.This proposal will address these deficiencies through two complementary aims:- Coral occurrence: 'to examine the physical forcing factors underlying cold-water coral occurrence in the US South Atlantic Bight',- Trans-Atlantic Study: 'to produce a clear conceptual framework for the first ocean basin-scale assessment of cold-water coral ecosystems'.The fellowship will enhance the career of the applicant by giving a period of sabbatical (University of North Carolina at Wilmington, USA, 16 months) during which he can focus solely on the fellowship objectives and benefit from access to new data, expertise and advanced infrastructure available in the USA.Following this, a re-integration period at the applicant's employer (Scottish Association for Marine Science, UK, 8 months) ensures that the benefits of the mobility period are transferred back to the European Union.As well as enhancing the applicant's international collaborations, this proposal is designed to strengthen deep ocean research links betwe