RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Grossflaechige beschichtung komplex geformter substrate mit Diamantschichten' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

p - BEST, the new diamond coating technology, has previously unachievableapplications in important industrial fields. A special emphasis is placed onone of the most important parameters, which in the current state of technology,cannot be changed, namely the enlargement of the coating surface. With p - BESTtechnology, any threedimensional surfaces, whatever the shape, can be coated,without having to take account of the problems inherent in the former process. Preliminary uses in the field of protection against wear are planned - in thesecases selective tools and medical implants will be coated. It is hoped that newtechnology can also be applied in other areas where a diamonds qualities, such as hardness, low friction, resistance to aggressive substances, high thermal:conductivity and electronic properties, are important.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Design of foods with improved functionality and superior health effects using cereal beta-glucans'.

assistant: **Objectives**

For the first time beta-glean of high purity will be prepared from cereals on a large scale. The processing conditions will be optimised to provide different preparations with tailor-made functional properties for different uses. Several partners will characterize the preparations in detail using a modern combination of advanced chemical and physic-chemical methods in a joint effort. These new beta-glean preparations physiological effects (lipid and glucose metabolism) will be studied in an animal model and also in humans. The beta-gleans is thereafter added into food prototypes and the developed products properties with respect to health effects, taste and theology will be evaluated. Consumer attitudes to the food prototypes and the concept behind them will also be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Generation of stable transgenic embryonic stem cell lines'.

assistant: **Objectives**

Human embryonic stem cells (hESC) are pluripotent cells derived from blastocyst stage early embryos. Since the original publication a vast number of studies have described the differentiation of hESC and their potential in regenerative medicine. It is now well known that hESC might be used in cell replacement therapies in a number of severe degenrative diseases like Type I diabetes or Parkinson’s disease. In addition, hESCs and their derivatives could be used as tools in discovering new drugs and in understanding mechanisms of genetic diseases. HESC applications could also be used in toxicological studies reducing the need of animal experiments. Genetic manipulation of hESC will be a crucial issue in a variety of future studies. To elucidate the role of any given gene for example in directed differentiation or pathogenesis the loss- and gain-of gene function approaches are of major importance. Also, considering the potential therapeutic applications of the hESC their genetic modifications may be necessary. The first part of this proposal is designed to improve and test novel efficient and safe transposon-based gene transfer method in generating conditional transgenic hESC lines. Of special interest is the use of insulator elements around transgene to assure nonbiased expression of the integrated sequences. Several reports have indicated that in long term hESC cultures the cells aquire chromosomal aberrations. The observed karyotypic changes probably reflect the progressive adaptation of self-renewing cells to their culture conditions. This process has parallels with malignant transformation. Changes observed in hESC in culture reflect tumorigenic events that occur in vivo, particularly in testicular germ cell tumors (TGCT). A recent report indicated the formation of a c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Stay home or go beyond: deciphering the mechanisms underlying ARGONAUTE1 loading and sRNA movement in plants' (LoAGOding), addressing dissemination and exploitation.

assistant: **Impact**

Small RNAs (sRNA) are essential regulators of gene expression, controlling development and preserving genome integrity, all across eukaryotic organisms. To execute their final functions, sRNA are loaded into an ARGONAUTE (AGO) protein to guide through sequence complementarity the regulation of target genes. In plants, sRNAs are divided into small interfering RNA (siRNA) and microRNA (miRNA), and both can be loaded into AGO1 for cell-autonomous action, or move out of the cell to act non-cell autonomously. This proposal outlines a series of complementary experiments to mechanistically study the loading of sRNA into AGO1 and to understand how it contributes to the intra- and inter-cellular movement of sRNA in plants. By combining cell biology, RNA biochemistry, deep-sequencing analysis, nuclear fractionation methods, micrografting and super-resolution microscopy, this project aims at: i) characterize the nuclear and cytoplasmic sRNA loading complexes (LCs), ii) decipher the connection between sRNA biogenesis and LCs and, iii) determine how sRNA loading could affect the sRNA movement. The results obtained will advance the state of the art in plants in our understanding of AGO1 loading mechanism, the execution of the AGO1 function and sRNA movement. Studying these pathways goes beyond mere mechanistic knowledge, as sRNA movement is being exploited to modulate plant and pathogen gene expression towards improving crop productivity and enhancing stress/pathogen tolerance, a booming strategy known as Spray-induced gene silencing. Altogether, this project is expected to create a wealth of original information, providing a meaningful contribution to European excellence and competitiveness in the field.


**Keywords:** RNA silencing, sRNA loading, sRNA movement, ARGONAUTE proteins,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'User-friendly ICT tools to enhance self-management and effective treatment of depression in the EU' (ICT4DEPRESSION), addressing dissemination and exploitation.

assistant: **Impact**

Major depression is currently the fourth disorder worldwide in terms of disease burden, and is expected to be the disorder with the highest disease burden in high-income countries by 2030. Estimated costs of depression are annually 177 and 147 million euro per 1 million inhabitants for major and minor depression respectively. Current treatment methods for depressive disorders can reduce the burden of this disease with about one third. The ICT4Depression consortium will develop an ICT-based system for use in primary care that will further improve patient outcomes and increase access to treatment. All technologies to be developed will be beyond state of the art and include 1) devices for monitoring activities and biosignals in a non-intrusive and continuous way, 2) treatments for depression and automatic assessment of the patient using mobile phone and web based communication, 3) computational methods for reasoning about the state of patients, progress of therapies, and the risk of relapse and 4) a flexible system architecture for monitoring and supporting people using continuous observations and feedback via mobile phone and the web. The ICT4Depression system is flexible and can easily be adapted for treatment of other mental diseases. The project will be carried out by an interdisciplinary consortium with 5 (research) organisations and 2 SME companies at the forefront of  Artificial and Ambient Intelligence, wireless biosignal sensors, activity monitoring using cell phones, monitoring patient compliance with drug prescriptions, service oriented application for the health care domain, psychology, psychiatry, and internet-based psychological treatment. The project will boost European leadership in ICT-based treatment of mental illness and will provide ample opportunities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regenerative Medicine' in the context of a Sixth Framework call.

assistant: **Objectives**

Regenerative medicine is critical to the future success of modern medicine and involves using the body's own stem cells and growth factors to repair organs, tissues, and cells. This new discipline is essential if we are to be able to repair tissues damaged in common chronic diseases such as diabetes, arthritis or Alzheimer's disease. Regenerative medicine involves new and ground breaking technologies such as stimulating tissue regeneration in situ, grafting of stem cells to bring about repair, transdifferentiation of one tissue type into another, and creating functional tissues and organs by tissue engineering.The Bath Centre for Regenerative Medicine (BCRM), founded at the University of Bath, UK in 2003, is an interdisciplinary and collaborative research network within the University. The BCRM is unique in Europe in the range of expertise and technology that it brings together in an interdisciplinary and cross-faculty collaboration. The BCRM will comprise eleven group leaders by October 2006 including a clinical interface. Fellows will be exposed to the full range of modern intellectual concepts and technical approaches that underpin this growing research area.The Centre will provide for each Fellow a high-level research training environment with state-of-the-art facilities, international quality researchers, visiting speakers from throughout the world, opportunities to go to national and international meetings, and training in both specific skills related to their research project and complementary skills that have already been adopted across the University as essential components of research postgraduate training. In terms of the relation between science and society, regenerative medicine highlights many of the key issues: e.g. stem cell research, transplantation sur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Recycling and recovery of polyamide in automotion and others applications' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The scientific and thecnical objectives of this research proposal concern the characterization of the different types of residuals from polyamide and other technical plastics that are produced in several phases of the life cycle of the material,as well as the recycling and recovery,and which new formulations and applications are allowed to increase their value. Research is required to identify which sectors (automobile , textile, electric...)are prioritaire for such applications. Develop the adequate technology and procedures for applications to industrial scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Thematic network on the development of European strategies to promote short sea shipping, sea-river and inland navigation'.

assistant: **Innovation**

The objective of the SPIN network is to develop a European Strategy to promote Inland Navigation and to encourage the acceptance and exploitation of the strategy. The proposal reflects option a) in the description of Task 2.3.2/14, the Key Action Sustainable Mobility and Intermodality" of the 5th Framework programme "Competitive and Sustainable Growth", which foresees separated Thematic Networks for Inland Navigation and Short Sea Shipping. Nevertheless, co-ordination with a parallel Short Sea Shipping network is planned. Although one third of the intra-community freight is carried on the European Inland Waterway Transport (IWT), it has not increased proportionally with the high growth in road transport. This demands further action from, policy-makers to obtain a more environmentally sustainable transport system. The need for the environmental friendliness of Inland Navigation will grow with the enlargement of the European Union towards Eastern Europe."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Chemical reactor modelling for fast exothermic and mixing sensitive reactions' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content Many of today's chemical products can only be made because of fundamental advances in the understanding of mixing processes. The new novel products and their manufacturing technology are to be developed based on fundamental know how of factors affecting in mixing sensitive reactions when the process is scaled up from laboratory to full scale production. The objectives of this project comprises advanced chemical reactor modelling exploiting computational fluid dynamics (CFD) and advanced flow patterns measuring technique development for model validation. CFD appears the ideal solution to this problem, but owing its origins outside the process industries it is not currently capable of realistic modelling of chemically complex systems. Additional modules are required for many common processes, of which fast chemical reactions probably have the highest immediate value to industry. These required modules will be developed in this project as well as the validation of the model using commercially important chemical reactors. The generated model will also be exploited in reactor development for two mixing sensitive commercially important reactions. This project proposal include also a substantial interdisciplinary- scientific contribution connecting chemical and fluid flow phenomena. The numerical part of this project will rely heavily on previous successfully conducted EC RTD programmes in CDF-area. The main deliverables of the proposed work are the provision of a validated chemical engineering tool, which represent a significant step forward beyond the existing state-of-the-art. Chemical industry will exploit the results in accelerated scale up research and the safe and optimal design of reactors. The main industrial benefits will be the following : - L
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Application of state-of-the-art approaches from statistical physics to understand the spatio-temporal behaviour of earthquakes and to assess time-dependent hazard'.

assistant: **Innovation**

We aim to better understand the physics of earthquake dynamics from the point of view of statistical physics where regional seismicity patterns are studied, regarding for example growing spatial correlation prior to large events. The theoretical framework is criticality and complexity. The approach shows promise for forecasting the location of large events while much work remains with respect to time and magnitude.We also address the prevalent problems of bias in data selection and decomposition of seismicity patterns by applying parameter-free methods such as Principal Components Analysis (PCA) which robustly quantify changes in the entire space for the first time. Enhancement of these methods, comparison, interpretation and systematic testing with real and synthetic earthquake catalogues will be the main activity. To efficiently carry out this work, receive most competent supervision and collaborate in a truly ideal setting we propose for the researcher, Dr. Goltz, to visit the Dept. of Geology at University of California Davis, USA.The researcher would be supervised by Profs. Donald L. Turcotte and John B. Rundle. Prof. Turcotte recently established a program on earthquake physics with Prof. Rundle who also heads the newly established Centre for Computational Sciences and Engineering (CCSE). Dr. Goltz has developed PCA for earthquakes simultaneously with but independently from similar work by the group of Prof. Rundle. Both developments led to the same conclusions. Joining the program at U.C. Davis thus constitutes a rare and ideal opportunity.The proposed activity blends perfectly with Dr. Goltz's career plan and those of the Dept. of Geophysics at Kiel University. He currently heads a small group on statistical earthquake physics and geoinformatics which is planned
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Miniaturised gasoline fuel processor for fuel cell vehicle applications (MINIREF)' in the context of a Fifth Framework call.

assistant: **Objectives**

The final objective of this project is to reform gasoline in order to power a fuel cell in a car. The goal of the MINIREF project is to demonstrate the feasibility of the use of miniaturised fuel processors, using micro channels technology, to make syngas from gasoline, by sPOX reforming and/or auto thermal reforming. The program should allow realising a 5 kW system, made of a reforming art, a WGS part and a PrOx part, a feeding system, and a heating/cooling system using micro channels. The reforming, WGS and PrOx catalysts will be optimised, and in-channels catalysts deposition techniques will be developed and optimised, as well as micro channels geometries, The same catalysts for monoliths will be tested too, in Order to make a real comparison of micro channels performances. Costs and industrialisability will be evaluated too.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Geomaterials: from Waste to Resource' (GeoRes), addressing dissemination and exploitation.

assistant: **Impact**

GeoRes aims to expand the scope of the involved teams’ research in addressing some of the outstanding challenges in geotechnical and geoenvironmental engineering: developing innovative solutions for the reuse of waste geomaterials generated by construction and mining industries across Europe. Geomaterial waste represents half of the waste volume generated in EU-27. These waste geomaterials generally exhibit poor engineering characteristics that prevent their direct reuse on construction/mining sites. However, if adequately treated, they could represent an excellent resource for construction purposes with significant money saving and reduction in the environmental footprint, thus contributing to the establishment of a circular economy. To achieve this, GeoRes will develop protocols, software and tools to improve the engineering characteristics of waste geomaterials, and to guarantee the level of performance over the service life of geostructures built from waste geomaterials considering site-specific conditions. The fundamental concern of the research in the GeoRes network is thus to develop strategies and tools for sustainable reuse of waste geomaterials generated by geoengineering activities, and to determine how to turn a waste geomaterial into a valued durable material, with a positive revenue stream. The proposed network is at the interface of two domains of engineering; geotechnical and geoenvironmental. Even today, it is not easy to find researchers with expertise in both geotechnical and geoenvironmental engineering. We intend to form a multidisciplinary and intersectoral consortium composed of 8 academic and 6 industrial beneficiaries and 6 Third Country partners which aim to address this problem. GeoRes will create a multidisciplinary and intersectoral network