RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Key features of cysteine proteinase mechanism defined by kinetic, spectroscopic and protein engineering techniques' under Fourth Framework.

assistant: **Concept**

Research objectives and content The cysteine proteinase superfamily which includes enzymes of biological and medical importance is a source of natural structural variants of value in the investigation of mechanism. Recent work in the QMW Laboratory has produced definitive evidence that the ion-pair state (Cys25)_S-/(HislS9)-/Im+ (C-H+) is formed across pKa valueS 2.5-3.3 and is fully developed at low pH where the enzymes are inactive. Catalytic competence requires an additional protonic dissociation at higher pH values with a pKa value close to 4. Experiments on Asp158Asn mutants have ruled out Asp158, the nearest carboxylate to the ion-pair, as the electrostatic switch. Electrostatics potential calculations suggest that two electrostatic clusters, centred on Glu50 and Glu 135 respectively, are prime candidates to contribute the carboxylate switch. The research objective is to generate a range of mutants of papain and caricain and to characterize the active centre chemistry and catalytic characteristics by stopped-flow kinetics using specially designed and synthesized time-dependent inhibitors as reactivity probes. Crystal structures of the key mutants will be determined in collaboration with IFR, Reading, UK. The ionization characteristics of the catalytic site histidine sidechains will be determined by NMR spectroscopy. The project will produce a detailed description of cysteine proteinase mechanism and will contribute substantially to our understanding of the roles of electrostatic effects and key binding interactions in catalytic site chemistry. Training content (objective, benefit and expected impact) Studies on the natural cysteine proteinase variants and the key mutants will properly define for the first time the catalytic mechanism of this class of enzymes. Trai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterization of the molecular mechanism behind CTL - the major choline uptake system in eukaryotes' (CTL).

assistant: **Innovation**

Choline is an essential nutrient necessary for the synthesis of the membrane lipids phosphatidylcholine and sphingomyelin that constitute over 50 % of the total lipid content in cellular membranes. It is the precursor for key metabolites such as the neurotransmitter acetylcholine and the osmolyte and methyl donor betaine. Transmembrane uptake of choline is the essential, but still enigmatic, first step in choline metabolism in the cell. Three groups of solute carriers have been identified in the transport of choline; CHT1, OCT and CTL (SLC5A7, SLC22, SLC44 in humans). While CHT1 and OCT perform specialized functions, the choline transporter-like (CTL) family facilitates the majority of choline uptake in all eukaryotes. Despite their clear physiological relevance, our knowledge of CTL family members is very limited, and there are no structures of choline transporters available. For this reason, knowledge on the molecular mechanism of cellular choline uptake is almost non-existent.With this proposal, I will address this lack of data, and provide new and ground-breaking insights into the function of the CTL family members. I will elucidate the molecular mechanisms of substrate recognition and transport in the major eukaryotic choline uptake system through a combination of structural biology (X-ray crystallography and cryo-EM) and biochemical characterization. The project will focus on human CTL family members but will also include other eukaryotic CTL proteins. A structural framework on the CTL family will provide insight into a key metabolic uptake pathway present in all eukaryotes and will be a fundamental resource for further research. Furthermore, CTLs are implicated in several diseases, including cancer, and the proposed work on CTL proteins will allow for future phar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Full Aero-thermal Combustor-Turbine interactiOn Research' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

To achieve lower Specific Fuel Consumption (SFC) and CO2/NOx emissions, modern turbomachineries operate at high velocities and high temperature conditions. The lack of confidence in the prediction of combustor-turbine interactions leads to apply extra safety margins on components design. Therefore, the understanding of combustor-turbine flow field interactions is mandatory to preserve High Pressure Turbine (HPT) life and performance when optimising the design of new HPT. The FACTOR objective is to optimise the combustor turbine interactions design to develop low-cost turbines and reduce SFC by 2%, HPT weight by 1.5% and accordingly engine cost by 3% compared to the results from the TATEF2 and AITEB2 projects.To achieve this objective, FACTOR will develop and exploit an innovative test infrastructure coupling a combustor simulator with a HPT for aerodynamic and aerothermal measurements. The infrastructure will improve the knowledge of aerothermal external flows since the inlet profile of the turbine and the secondary flows will be modelled and optimised together in the same facility, under engine representative conditions. Collected data will be fed into the design techniques and simulation software used to optimise HPT components. In parallel, the use of advanced CFD (e.g. LES or DES) will provide new knowledge on wall temperature and heat transfer predictions. This will be particularly important to design future combustor-turbine systems in an integrated manner, especially for the next generation of lean burn combustion systems having complex and severe flow constraints.By optimising the combustor-HPT interaction, FACTOR project will contribute to achieving the 50% CO2 and 80% NOx reductions ACARE 2020 environmental objectives. FACTOR will also strengthen the competiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Exciton Transport in Molecular Crystals: The Role of Dynamic Disorder', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The need to develop renewable energy sources has stimulated a rapid growth of photovoltaic technology which uses solar energy to directly convert the daylight into electricity. Photovoltaic cells based on π-conjugated organic materials, also known as organic solar cells, potentially offer a significant reduction cost compared to inorganic solar cells and allow for large-scale production since organic materials can be solution-processed. However, the fundamental processes that determine the efficiency of these organic photovoltaic cells are still not understood. In particular, a deeper molecular-level comprehension of the exciton transport and charge generation mechanisms that take place in these photovoltaic devices is crucial to rationally design novel and enhance organic semiconducting materials for highly-efficient photovoltaic devices.The aim of this project is to develop a theoretical model able to give an appropriate description of the exciton transport mechanism in molecular crystals and to explore the connections between this mechanism and the free charge generation in photovoltaic junctions. Emphasis will be made on the role of the dynamic disorder but the other elements highlighted in the recent literature (vibronic effects, charge transfer excitons) will be included as well. The formalism will be complemented by atomistic study of the nuclear dynamics and electronic structure calculations so that accurate parameters can be feed into the model. Finally, the improved understanding of the exciton wavefunction will be used to provide a microscopic picture of the exciton dynamics in bulk and near the interface with an electron acceptor.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Boom and Bust Cycles in Asset Prices: Real Implications and Monetary Policy Options' to be submitted under Seventh Framework.

assistant: **Abstract**

I seek increasing our understanding of the origin of asset price booms and bust cycles and propose constructing structural dynamic equilibrium models that allow formalizing their interaction with the dynamics of consumption, hours worked, the current account, stock market trading activity, and monetary policy. For this purpose I propose developing macroeconomic models that relax the assumption of common knowledge of beliefs and preferences, incorporating instead subjective beliefs and learning about market behavior. These features allow for sustained deviations of asset prices from fundamentals in a setting where all agents behave individually rational.The first research project derives the derivative price implications of asset price models with learning agents and determines the limits to arbitrage required so that learning models are consistent with the existence of only weak incentives for improving forecasts and beliefs. The second project introduces housing, collateral constraints and open economy features into existing asset pricing models under learning to explain a range of cross-sectional facts about the behavior of the current account that have been observed in the recent housing boom and bust cycle. The third project constructs quantitatively plausible macro asset pricing models that can explain the dynamics of consumption and hours worked jointly with the occurrence of asset price boom and busts cycles. The forth project develops a set of monetary policy models allowing to study the interaction between monetary policies, the real economy and asset prices, and determines how monetary policy should optimally react to asset price movements. The last project explains the aggregate trading patterns on stock exchanges over boom and bust cycles and improves our un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Impact of poplar bioenergy cultivation on ozone and volatile organic compound emissions' (SRF-OZO) targeting Seventh Framework.

assistant: **Abstract**

The need for renewable energy sources to meet EU Directive 2009/28/EC is expected to lead to a considerable expansion in the planting of dedicated fast-growing biomass crops managed as Short Rotation Forestry (SRF). Among them Poplar (Populus spp) is currently the most widely planted SRF species and thus an increase in large-scale SRF poplar plantations might be expected. Poplars are characterized by a considerably high isoprene emission coefficient, and are susceptible to ozone pollution. In this project we will – for the first time – simultaneously measure the fluxes of Biogenic Volatile Organic Compounds (BVOCs), ozone (O3), and NOx emission in combination with the  greenhouse gases (CO2, CH4 and N2O). All these flux measurements will be made in an SRF poplar plantation located in Lochristi (Belgium) using the eddy covariance technique. The primary objectives of the project are: (i) to quantify the NOx, BVOC and O3 emissions at leaf and ecosystem levels, and (ii) to identify the environmental variables that drive these fluxes. The data obtained will be used to parameterize the CTM LOTOS-EUROS and the CTMs Chemical Transport models. Model simulations will reveal the potential impact of large-scale biomass plantations on isoprene emissions, and consequently on ozone air pollution at the European level. The study will also quantify the Global Warming Potential of poplar SRF and the carbon offset that could be achieved with the bioenergy produced. This project will establish a scientific collaboration with the Great Lakes Bioenergy Research Center (GLBRC) of the US Department of Energy to share data and write joint publications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Constraining Stellar Mass and Supermassive Black Hole Growth through Cosmic Times: Paving the way for the next generation sky surveys'.

assistant: **Objectives**

Understanding how galaxies form in the early universe and how they evolve through cosmic time is a major goal of modern astrophysics. Panchromatic look-back sky surveys significantly advanced the field in the past decade, and we are now entering a 'golden age' of radio astronomy given an order of magnitude improved facilities like JVLA, ATCA and ALMA. I am leading two unique, state-of-the-art (JVLA/ATCA) radio surveys that will push to the next frontiers. The proposed ERC project will focus on the growth of stellar and black-hole mass in galaxies across cosmic time by: 1-probing various types of extremely faint radio sources over cosmic time, revealing the debated abundance of faint radio sources, 2-exploring star formation conditions at early cosmic times, allowing to access for the first time the dust-unbiased cosmic star formation history since the epoch of reionization, 3-performing the first census of high-redshift starbursting galaxies (SMGs), and their role in galaxy formation and evolution, and 4-performing a full census of galaxies hosting supermassive black holes (AGN), with different black-hole accretion modes, and their roles in galaxy evolution.The exploitation of these radio sky surveys is essential for the preparation and success of the future large facilities like ASKAP, and SKA as they will 1-provide best predictions of the to-date uncertain cosmic radio background seen with the SKA, and 2-optimize photometric redshift estimates, essential for the success of the first ASKAP sky survey (EMU, >2016).My radio surveys, expected to yield >100 refereed publications, carry an immense legacy value. The proposed ERC funding is essential for the success of these timely surveys, which I will conduct from Croatia. The ERC grant will allow me to lead my own research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Public Cults in Private Hands: the Appropriation of cult sites from the 2nd century BC to the 2nd century AD' under Horizon 2020.

assistant: **Concept**

.Drawing on exciting new discoveries in the Colli Albani area, the CULTUS project offers an unprecedented opportunity to explore the role of religion in Roman élite competition, identity creation, and state ideology, from the perspective of actual practice, agency, and integration into daily activities and more mundane physical surroundings. The identification of the famous sacrarium of Bona Dea at the ʽVilla of Clodiusʼ, Castel Gandolfo, and a re-assessment of the villas of Secciano and La Torretta, have closed important gaps in our knowledge of the Colli Albani’s sacred landscape, and have paved the way for the successful application of an innovative approach that moves away from still-prevailing paradigms of normative and static concepts of religion, and binary oppositions such as public/private or official/popular. Focussing on the much-neglected semi-public cult sites situated in private properties, the study aims to identify the patrons of these initiatives (male and female private individuals; emperors), and the reasons for their actions (self-promotion and socio-political ‘cultural capital’) over four centuries of extensive change in Roman political and social history (2nd c. BC to 2nd c. AD). The project comprises five work packages: Comprehensive data collection (WP1) and analysis (WP2) of three main case study sites and several comparative sites; the interpretation and contextualisation of these findings in a wider set of historical questions (WP3); training and outreach activities (WP4 and 5). Key concepts to be developed further are: (a) the ‘mapping of social history’ that proposes to study human action and interaction from the perspective of their spacial interconnectedness; (b) ‘lived ancient religion’ that emphasises individuals as religious agents inst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SOURCE AND TOXICOLOGICAL PROFILE OF AIRBORNE PARTICLES IN AFRICAN MEGACITY' (SO-TOX).

assistant: **Innovation**

African countries are home to some of the worlds most polluted cities, where bad air quality is the most potent risk factor for mortality. However, they are nearly unrepresented in the research on air pollution levels and health impacts. Without adequate knowledge of air quality and mitigating the sources of pollution, the problem will only get worse given Africas expected population boom. This project through a holistic framework involves a strong exposure-health linked dual-component in the profile of PM to understand the current status of air pollution in Luanda (Angola). It aims to answer the following 3 main questions as; What causes air pollution? What are the effects? What are the possible solutions to tackle it?The project will focus on two different levels, source identification through receptor model techniques, and in-vitro assessment of cytotoxic and genotoxic properties of the PM to link physicochemical characteristics of air pollution to health risks. The first source profiling and toxicological screening of air pollution in Africa (Luanda) will contribute to understanding the causes of poor health and defining regional and national policies aiming at improving wellbeing in Luanda and other African cities with similar problems, making them more resilient and sustainable. This will represent a chance to review/adopt legislation, propose source-oriented cost-effective control strategies, and lay the foundations for a future measurement network. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. The project will have a strong connection with the recent World Health Assembly resolution, which has set actions to address air pollution and its health risks in Africa as a prio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The world's first edge computing solution for SMEs enabling energy efficiency, Industry 4.0 and new business models for the energy sector' in the context of a Horizon 2020 call.

assistant: **Objectives**

ENIT Energy IT Systems is a leader in smart grid technology, founded in 2014 as a Fraunhofer spin-off. The pilot product, ENIT Agent 1.0, is an innovative energy management system based on edge computing, combining the advantages of cloud and decentral optimization for the target market of industrial, energy-intensive SMEs. Since 2016, over 100 pilot customers confirmed its feasibility and valuated three USPs: fast and simple installation (<10 minutes), flexibility by integrating existing infrastructure and higher data accuracy for improved efficiency analytics. A local food manufacturer reduced its yearly energy consumption by 230tkWh, saving €40t.While the ENIT Agent 1.0 focuses on monitoring energy efficiency, the project‘s objective is the full exploitation of edge technology‘s potential, offering solutions for three crucial European challenges: 1) increasing energy efficiency by data driven analysis; 2) offering interoperable industry 4.0 interfaces to integrate energy data, industrial process data and business intelligence; 3) enabling new business models in the energy sector by integrating SMEs for direct participation. These objectives are achieved by adding an open API for third party applications and building a central/decentral IT infrastructure for upscaling the European rollout. For commercialisation, additional partners (industrial manufacturers, utilities, etc.) are acquired, supporting sales and using the API. Together with existing partners, ENIT develops new analytic applications reducing investment risks for PV, batteries etc. by data driven ROI calculation. The funding significantly increases the strategic value for ENIT and its partners, the SMEs as customers and the European Union. ENIT was initiated by bootstrapping and award-funding, further fund