RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chromatin Remodeling in DNA Repair: the role of the INO80 complex' (INOHR) targeting Seventh Framework.

assistant: **Abstract**

The proposal aims at the study of the molecular mechanisms involved in the starting steps of the repair of the most severe type of DNA lesions, the double-stranded DNA breaks (DSBs). DSBs are caused by either environmental stress or by endogenous DNA metabolic processes. Inaccurate repair of DSBs leads to genomic instability, and thus, to cell death or cancerous malformations. Enzymes acting in DNA repair processes are required to access to DNA. This is, however, hampered by the compact and stable chromatin (DNA bound to histone proteins) structure. The project outlined in this proposal focuses on the investigation of the chromatin remodeling activity of human INO80 complex proposed to play role in the homologous recombination (HR) based repair of DSBs. The INO80 subfamily is the most recent addition to the SWI/SNF family of chromatin remodelers found in yeast, flies, plants and mammals. However, INO80 seems to be the most evolutionary conserved subfamily of chromatin remodeling enzymes, which has been found to play important roles in gene expression regulation, DNA replication and repair. INO80 exerts remodeling activities (e.g. nucleosome eviction, histone exchange) in a large enzyme complex. The human INO80 complex consists of a total of almost 20 essential and regulatory subunits. Precise mechanisms by which the human INO80 complex performs chromatin remodeling activities are still unrevealed, yet. We are addressing the key questions regarding the fate of the nucleosomes upon remodeling by the INO80 complex: Are they moved? If yes, how far? Are they replaced? If yes, when? By using a fluorescently labeled subunit of the INO80 complex and/or histone components of the nucleosome, an array of single molecule and ensemble approaches will provide insights into the functi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improved removal of particulate contaminants from surfaces to increase functionality and appearance of products (REPART)' in the context of a Fifth Framework call.

assistant: **Objectives**

This project will focus on the problem of removing particulate contaminants from surfaces by development of improved cleaning chemicals and procedures. This will also include particle analysis and design of eco-efficient processes. Chemical and mechanical methods will be combined to improve the cleaning efficiency. A new method of applying mechanical forces at the point of the attachment of the particle, using electroosmosis is proposed. The project will result in less cassation, higher quality, longer lifetime and a higher functionality of products as well as a lower production cost and a higher customer value. The improvement of the cleaning efficiency in combination with the increased recycling of water and process chemicals will also lead to reduced waste and lower consumption of resources.After finalising the project work with this issue we achieved the following deliverables:General delivarable:1. -Improved technology level on particle removal.Specifc deliverables:2. - Optimised surfactants for use in formulations for the particle cleaning case at Sandvik, Volvo and Philips;- Chemical formulations optimised for the selected case study;- Evaluation of chemical systems-pilot plant:3. - Optimisation of cleaning chemicals and process for interior of seemless stainless steel tubes, post-pilgering operations;- Improved removal of lapping paste residues from aluminium surfaces, using an aqueous cleaning medium;- Optimisation of the cleaning process for air bearing;4. - Dev of new method - electroosmosis and interesting preliminary results with the method combined with other methods;- Evaluation of electro-osmosis for removal of particulate contaminants from polyimide-coated glass plates;5. - Results on optimal use of ultrasound cleaning;6. - CO2 cleaning has been demonst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'lambda -- full colour, energy efficient, ultra-thin and bendable reflective display.' in the context of a Horizon 2020 call.

assistant: **Objectives**

More than 50% of a computer’s energy is used to fuel the screen. Many screens feature traditional LCD (Liquid Crystal Display) technology, which, while versatile, is backlit, requiring a continuous power source. The most energy efficient screens on the market are instead reflective, such as EPDs (Electrophoretic Displays). An EPD device does not consume energy when displaying an image or text – it only requires power when changing images. Unlike LCDs, EPDs can be read in direct sunlight. However, currently available EPDs are limited to black and white, or very poor colour. EPD producers have been trying to commercialise full-colour reflective displays for more than 10 years, without success. The best attempts have led to expensive products with only one or two lacklustre colours, or products that are not commercially viable as they do not meet consumer demand, in terms of e.g. the refresh rate. For rdot, this is not good enough. Beyond books, the modern consumer wants to read comics, manga, PDF files, textbooks, newspapers and magazines. Wearables and digital signs also need to be colourful and readable in sunlight. Furthermore, the solution must be thin and flexible, so the display can be wrapped around any object or device. This provides a huge untapped global market opportunity: to date, the technology to offer a bendable, thin, colourful and true-life display with a dramatically reduced energy consumption has not been developed. rdot will fill this gap in the market. Our innovative display, lambda, offers 98% energy savings compared to LCD and 80% energy savings in comparison to leading EPDs, and is revolutionary in its provision of full colour rendering. It is also bendable, and the thinnest display on the market – thinner than a strand of hair – making it suitable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Supramolecular photocatalytic late-stage C-H functionalization'.

assistant: **Concept**

Organic synthesis is still one of the main limiting factors in drug-discovery projects. Traditionally, the generation of compounds libraries requires tedious synthetic routes to introduce modifications into the lead compound, thus the implementation of new methodologies to modify drugs in a selective way in the late stages of their synthesis is highly attractive.In SupraPhoCat project, several supramolecular receptors will be provided with catalytic activity and combined with photoredox catalysis to achieve unprecedent asymmetric C-H funtionalization reactions with exquisite selectivity, using CO2 as non-toxic abundant C1 building block. This ambitious project will establish new methodologies for C-H Late-Stage Functionalization of drugs, which is a key point towards the development of libraries of compounds according to EU green chemistry insights.This Marie Sklodowska Curie action will merge the expertise of the host group (Prof. Luca Dell’Amico, NanoMolCat group from University of Padova) in CO2 valorisation methods and photoredox catalysis with the expertise of the fellow on supramolecular chemistry, molecular recognition and organocatalysis. Also, this project has been designed to augment and complement the research and transferable skills sets of the fellow and will greatly enhance his career prospects to become a mature and independent scientist. Through the training and the research results arising, the fellowship will be beneficial to the candidate, the host institution and European scientific and social environment.This research will allow a great improvement of the state-of-the-art in the construction of active organic molecules through a new, powerful, and impacting synthetic methodology, raising the standing of EU chemistry within this field at a global lev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'RECYCLE, REPURPOSE AND REUSE END-OF-LIFE WIND BLADE COMPOSITES – A COUPLED PRE- AND CO-PROCESSING DEMONSTRATION PLANT', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

By 2030, renewable Energy Sources (RES), and its infrastructures, are expected to increase 40% in Europe. Parts of RES strategies are onshore and offshore wind energy. The investment into new RES infrastructure implies an update of the current wind turbines, resulting in waste of the composite materials that constitute blades. To turn RES into the most promising and economically viable sources of renewable energy, we need to provide clean renewable energy without any emissions during operation. The blades, among the most important components in the wind turbines, made with composite, are currently regarded as unrecyclable. It is estimated that by 2050 the end-of-life (EOL) blades waste will generate more than 2 Mt annually, and cumulative blade waste in 2050 will lie between 21.4 Mt and 69.4 Mt, worldwide. EOL options for decommissioning wind turbine blades should be explored with the aim of providing environmentally favorable guidelines for managing wind turbine blade waste, and the possibility for material recovery and recycling is crucial if circular economy is the goal in the wind power sector. One possibility to avoid the accumulation of EOL blades in the environment is to convert the composite blades into new environmentally friendly building materials such as green cement. This option would demand some processing of the composite waste. Another option could be the reuse of the blades directly without much processing, e.g. . as new blades or as other products. Furthermore, the composite waste from blades could be combined with similar waste from other industrial sectors to enlarge the potential of a composite wind blade recycling process.Therefore, the general scope of the proposed project is to evaluate and demonstrate in large scale the possibility of recycling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of Group B Streptococcal vaccine to alleviate emerging antibiotic resistance through elimination of current prophylactic antibiotic strategies in GBS prevention.'.

assistant: **Innovation**

The NeoStrep project will develop a novel vaccine against Group B Streptococcal (GBS) infections, responsible for 50% of life-threatening infections in newborns. The aim is to provide a safe and effective alternative to current generally implemented antibiotic prophylaxis. Emergence of clinical isolates of GBS with reduced susceptibility to penicillin (the preferred prophylactic antibiotic) and pattern of genetic mutations in penicillin binding proteins of GBS is identical to that observed in Streptococcus pneumoniae prior to the breakthrough of true widespread penicillin resistance in that pathogen. Combined with already existing resistance to a wide range of other antibiotics, this indicates current GBS antibiotic prophylaxis is highly vulnerable to antibiotic resistance. Emergence of widespread antibiotic resistance threatens to return the incidence of GBS disease to pre-prophylaxis levels with the associated significant increases in health cost and morbidity/mortality caused by infections with resistant GBS.The NeoStrep project aims to eliminate the use of prophylactic antibiotics in GBS prevention and hence the problem of emerging antibiotic resistance in GBS through the development of a GBS vaccine.No approved vaccine currently exists, and one currently in development only covers a subset of clinical serotypes. The NeoStrep vaccine, which is based on a novel fusion protein approach, has a wider serotype coverage (95%) and is much cheaper to manufacture than the other GBS vaccine candidate in development. The vaccine is extensively validated in animal models, and a simple production method has been developed.The objective of the project is therefore to advance the vaccine through cGMP production, tox studies and into clinical trials, with the aim of generating proo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Metallurgical control of filiform corrosion of aluminium rolled products' (1994-1998).

assistant: **Concept**

BE95-1142 Metallurgical Control of Filiform Corrosion of Aluminium Rolled Products The future of the aluminium rolling industry in Europe depends on large volume production and sale of coil treated painted products. The present market is mainly for architectural applications which is under serious threat in coastal areas of Belgium and Holland due to filiform corrosion experienced in service. The future market is in automotive sheet that has enormous market potential both for body panels and for automotive structures. Prevention of corrosion of painted sheet in automotive applications is therefore of paramount importance particularly as this market is in its infancy and confidence in the usage of aluminium must be maintained. In particular, filiform and other forms of underfilm corrosion, must be prevented irrespective of the metal source (primary, remelt or recycled), the casting technique (direct chill, electromagnetic or continuous), the fabrication practice, the surface treatment technology and the alloy system. In addition, all processes used, especially in surface treatment, must be environmentally friendly and economically attractive. The use of recycled metal is an important issue as the automotive industry will soon be faced with an EC law which will demand that car manufacturers take back used cars and ensure subsequent recycling and similar legislative measures are under consideration for the building industry. The key need is to understand how the metallurgy of the aluminium substrate as determined by metal source alloy composition, casting, processing and surface treatment controls filiform corrosion resistance. Once this understanding is achieved composition control and modified production practices will be developed and instigated to ensure that irrespect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanoscale magnetic and thermal imaging of strongly correlated electronic materials' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Strongly correlated electronic materials have phase diagrams that are intrinsically complex. Multiple, distinct, broken symmetry phases can occur simultaneously and the presence of these intertwined orders gives rise to spontaneously inhomogeneous electronic structures. Observing and characterizing these patterns is crucial to understanding the mechanisms that govern these electronic states. I propose to study these phases using a novel scanning SQUID microscope with single electron spin sensitivity and thermal sensitivity better than one millionth of a degree. The SQUID is mounted on a nanometric tip and has ~50 nm resolution. I will expand the experimental capabilities of this technique by improving the resolution to a few nm, and by enabling near field microwave microscopy.Local magnetic probes are ideal for spatially resolving magnetic order and can also be used to probe local superconducting phase fluctuation since they generate local currents and thus local magnetic fields. However, the required resolution is of the order of a few nm, which is far beyond the capabilities of most local magnetic probes. While thermal microscopy provides information about dissipation mechanisms, which is relevant in high Tc superconductors (HTSC) above Tc where superconducting correlations are locally present, there is no technique that can perform thermal microscopy at low temperatures. The SQUID-on-tip will allow us to look at all the above-mentioned aspects. We propose to look at three types of systems (1) Observe local signatures of pair-density waves and other manifestations of broken time reversal symmetry in HTSC (2) Characterize the unconventional superconducting phase at the LaAlO3/SrTiO3 interface (3) Study the inhomogeneous magnetic phases at the LaMnO3/SrTiO3 interface. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'DEVELOPMENT AND MARKET UPTAKE OF A GHZ-RATE FIBRE LASER FREQUENCY COMB FOR ELASTIC OPTICAL NETWORKS'.

assistant: **Objectives**

FYLA, which is a company highly specialised in the design, production and manufacturing of ultrafast fibre lasers, is requesting the SME instrument for their innovative product LASERCOMB.  It is an outstanding fibre laser frequency comb that will enable the new communication paradigm based on Elastic Optical Networks (EONs) and Super-Channels.One of the major challenges of photonics is to provide cost-effective technology to boost the broadband internet and allow current demands in terms of traffic growth, fast network changes and varying traffic.  For that purpose, network architecture innovations are needed to get faster, more transparent, dynamic and greener broadband networks, providing super-channels to offer connectivity with a wide range of bandwidths, dynamic over both time and direction. In this context, optical fibre laser combs feeding EONs will fulfil requirements of future core networks.LASERCOMB solution is a fibre laser frequency comb that will enable the new communication paradigm based on EONs and super-channels. It is an ultrafast GHz-rate pulsed optical fibre laser with better performance, flexible design and lower costs than the current state of the art solutions. Regarding flexibility, it is capable of generating a comb of multiple carriers (>1000) to feed multiple channels, offering wide flexibility in the fundamental frequency (1-25GHz) and bandwidth (1.5-20nm) of the carriers. Main advantages of LASERCOMB are:- High quality signals.- Multiple carriers generated from unique source (laser comb), providing coherence between carriers.- Long-term stable emission (hours and days of operation).- Robustness (increase life-time up to 5 times).- Reduce size and weight (at least 80%)- Reduce cost (50% compared to other comb lasers and 75% compared to curren
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ant navigation: how complex behaviours emerge from mini-brains in interaction with their natural habitats', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Navigation is one of the most crucial and most challenging problems animals face. Behavioural analyses have shown that animals make use of a number of different mechanisms to navigate, but very little is known of how spatial information is processed and integrated by the brain. This project will exploit the stunning ability of ants in learning long visual routes to investigate the mechanisms of navigation in a brain numerically much simpler than vertebrate. We will combine an ecological approach with state-of-the-art technologies to enable a thorough control of sensory-motor cues while the ant is navigating in virtual-reality reconstructions of its natural environments. This new and powerful method will enable us to dissect the mechanisms underlying the emergence of navigational behaviours by performing straightforward manipulations. The results will be modelled in the light of insect neurobiology and integrated into an increasingly complete neural architecture. This neural architecture will be embedded into an agent navigating in the same virtual-reality environment as the real ants for testing. The advantage of such an inter-disciplinary approach is that failures of our agent will help us identify gaps in our knowledge and thus fuel new experimentation. Reciprocally, our agent will become increasingly refined in the light of incoming experimental results. This will create a positive feedback towards a complete, multi-level understanding of navigation in the wild. The findings will inspire new robust solutions for navigational problems that can be applied to bio-robotics.