RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pinging the brain to reveal hidden neural states underpinning flexible human cognition' in the context of a Horizon Europe call.

assistant: **Objectives**

Human cognition is uniquely flexible. We can attend to different aspects of the world and make arbitrary connections between things we see and do, enabling us to perceive, think, and act adaptively. These foundational processes are thought to depend on frontoparietal brain networks, which prioritise relevant sensory information and organise it into temporary, task-specific structures. A key proposal is that flexibility arises from the rapid and transient linking of stimulus and response representations via versatile domain-general cells in these regions. Intriguingly, in this framework, a person’s knowledge of the current task is encoded in the temporary pattern of connections between neurons, rather than in explicit activity. However, studying these essential knowledge states in working brains is difficult, because the corresponding momentary patterns of synaptic potentiation are typically invisible to neuroimaging. PINGSIGHT will develop and use new methods to reveal these hidden neural states. We will inject non-specific ‘pings’ of energy into the system, through visual, auditory, and non-invasive transcranial magnetic stimulation, in the moments before and after active task performance. Then, we will use multimodal neuroimaging and multivariate decoding analyses to read out how the ping activity propagates in the brain, exposing the underlying patterns of synaptic potentiation. We will use this method to study whether and how these previously hidden brain states support two foundational features of flexible cognition: our ability to (1) attend selectively and (2) respond flexibly to the world around us. As well as revealing latent neural mechanisms underpinning these key core processes, there will be important cross-field impacts: exposing the importance of hidden n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on '3D Structure of Nanomaterials under Realistic Conditions'.

assistant: **Innovation**

The properties of nanomaterials are essentially determined by their 3D structure. Electron tomography enables one to measure the morphology and composition of nanostructures in 3D, even at atomic resolution. Unfortunately, all these measurements are performed at room temperature and in ultra-high vacuum, which are conditions that are completely irrelevant for the use of nanoparticles in real applications! Moreover, nanoparticles often have ligands at their surface, which form the interface to the environment. These ligands are mostly neglected in imaging, although they strongly influence the growth, thermal stability and drive self-assembly.I will develop innovative and quantitative 3D characterisation tools, compatible with the fast changes of nanomaterials that occur in a realistic thermal and gaseous environment. To visualise surface ligands, I will combine direct electron detection with novel exit wave reconstruction techniques. Tracking the 3D structure of nanomaterials in a relevant environment is extremely challenging and ambitious. However, our preliminary experiments demonstrate the enormous impact. We will be able to perform a dynamic characterisation of shape changes of nanoparticles. This is important to improve thermal stability during drug delivery, sensing, data storage or hyperthermic cancer treatment. We will provide quantitative 3D measurements of the coordination numbers of the surface atoms of catalytic nanoparticles and follow the motion of individual atoms live during catalysis. By visualising surface ligands, we will understand their fundamental influence on particle shape and during self-assembly.This program will be the start of a completely new research line in the field of 3D imaging at the atomic scale. The outcome will certainly boost the de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Ion ChaNnel SENSors'.

assistant: **Innovation**

Super-sensitive detection mechanisms offer numerous opportunities for fundamental science in fields such as biophysics and chemistry and are a highly needed advancement for applied fields such as medicine, environmental pollution monitoring and defence. Developing sensors that are even capable of detecting single molecules has therefore become an important field of research. At this moment there is a growing demand for a stable and sensitive molecular sensing method because the available sensing methods are insufficient.Dr. Kocer and her group have developed a sensory device based on biological ion channels. Ion channels are extremely sensitive transmembrane protein pores that open and close in response to chemical, electrical or mechanical stimuli. Dr. Kocer has built unique knowledge and expertise on the channel functioning that allows her to modify the sensory characteristics of these channels towards the detection of a certain analyte. Via a unique fabrication method a sensory chip has been constructed where ion channels can be reconstituted into an artificial bilayer lipid membrane. This has led to the development of a molecular sensing platform able to detect a large variety of analytes at the single molecule level.To maximise the full potential of the ion channels, we will explore in which fields a molecular platform can fulfil major unmet needs and develop a reliable molecular sensing platform. To achieve these goals, we will conduct market research, develop a sound commercialisation strategy, IPR strategy and a product development plan within the ERC PoC project. The project outcomes will be consolidated in a business plan and presented to investors including venture capitalists and other strategic partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Minimal Model for Pox-Virus Infection'.

assistant: **Objectives**

Viral diseases represent one of the world’s highest socio-economic burdens. Increased global trade and travel, climate change resulting in shifting viral vectors, and the emergence of new and often deadly viruses is inevitable. Therefore, detailed understanding of the complexity of virus particles and the development of new model systems to study them, will be essential to develop new research, diagnostic, and therapeutic tools. The structural changes that occur during the initial contact between a virus and its host remains one of the major challenges in infection biology. Until recently, the investigation of viral nano-architecture and dynamic changes that occur in virus particles during the infectious lifecycle was limited to methods, such as EM, with no capacity to capture dynamic events or define molecular specificity. The goal of the proposed project is to create a new minimal model of virus infection based on cell-derived membrane blebs. The model will be amenable to novel super-resolution microscopy (SRM) methods that allow the visualization of viral structures at resolutions of tens of nanometers. Recently developed analytical tools like single-virion averaging allows the generation of precise models from hundreds of events. This affords unprecedented insights into the biological and biophysical requirements of virus infection. Furthermore, we aim to investigate the dynamics of virus architectural changes during the first stages of infection, particularly at the membrane level, by combining single-molecule techniques with our new model-system. While initially aimed at investigating protein structure-function relationships within the prototypic poxvirus, vaccinia, the model system and imaging developments outlined will be broadly applicable to a wide range of bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'High-level training on complex systems and materials for young researchers'.

assistant: **Objectives**

In the past few years, complex systems and materials has become a major interdisciplinary scientific field involving physics, biology, chemistry, mathematics, medicine and social sciences like economy. The role of statistical physics in this new field of science and technology has been accelerating; in particular many different phenomena and processes (considered in the past as belonging to separate research fields) have now a common description. Methods developed for studying order phenomena in simple systems have been generalized to more complex forms of matter (polymers, biological macromolecules, glasses, etc.) and complex processes (e.g., chaos, turbulence, economy, jamming, biological functionalities). Pillars of such a description are scaling and universality. The aims of the proposed School are to provide an actual overview of the field and a more detailed examination of those topics within the field that are currently of interest in science and technology.The main objective of the School are: to educate the students in the concepts and specifics of this new interdisciplinary field of complex systems, to promote the formation and qualification of young researchers and their international collaborations, and foster the development of the actual knowledge in science and technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Novel gene drug strategy based on hybridisation of functional entities to plasmids.'.

assistant: **Objectives**

Gene therapy is an emerging technology with the potential of having an important impact on future treatments of human diseases. Efficient gene transfer relies on optimal receptor binding, intracellular vesicular transport and nuclear uptake. According to these requirements, a novel GENE DRUG therapeutic strategy will be developed. This strategy is asked on a patented plastid delivery system in which functional entities, improving delivery efficiency, are attached to the plastid by means of hybridisation. The proposal is focused on the delivery of therapeutic genes for cardiovascular diseases and haemophilia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GENETIC AND ENVIRONMENTAL BASIS OF NATURAL TRANSPOSITION AND ITS POTENTIAL TO CREATE ADAPTIVE VARIATION' (2014-2020).

assistant: **Innovation**

Transposable elements (TEs) are powerful engines of genome evolution, as illustrated by their implication in the rewiring of regulatory networks and the creation of new cellular functions. Short-term consequences of TE mobilization can also be particularly dramatic given that TE insertions are a unique source of large effect mutations. However, there is a lack of knowledge about the contribution of ongoing transposition to within-species variation. This situation stems in large part from the repetitive nature of TEs, which complicates their analysis. Moreover, TE mobilization is typically rare and therefore new TE insertions tend to be missed in small-scale population studies. Hence, a major challenge in genomics is to determine the conditions leading to transposition in nature and the range of effects it generates. While most TE insertions are likely to be deleterious or neutral, it is widely proposed that because TE activity can be sensitive to the environment, transposition may in fact act as a major adaptive response of the genome to environmental changes. Here, using large experimental and wild populations of the plant A. thaliana, I propose to leverage innovative genomic, molecular genetics and eco-evolutionary approaches to determine the Genetic x Environmental (GxE) map of heritable transposition and its contribution to the creation of adaptive variation.Aim 1 is to identify the genetic and environmental factors that underpin TE mobilization by quantifying newly generated heritable insertions in thousands of genetically diverse individuals subjected to a range of environmental stressors. Aim 2 is to determine the fitness effects of these heritable TE insertions using multigenerational competition experiments and highly complex environments.This project will grea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '5G MiEdge: Millimeter-wave Edge cloud as an enabler for 5G ecosystem' under Horizon 2020.

assistant: **Concept**

Current research efforts on 5G Radio Access Networks (RAN) strongly focus on mmWave access to realize enhanced mobile broadband (eMBB) services. However, there are many unsolved issues to deploy mmW ave 5G RAN. The most critical issue is backhauling since it is infeasible to provide 10 Gigabit Ethernet backhaul everywhere. Meanwhile, Mobile Edge Computing (MEC) have obtained much attention in 5G networks as a key technology to enable mission-critical (low latency) applications by allocating storage and computation resources at the edge of the network and circumvent the backhaul networks’ limited capacity. However, in the case of mobile networks, it is not easy to reallocate computational resources on demand, while meeting the strict latency constraints foreseen in 5G networks. In this project, mmWave access and MEC are firstly combined as a perfect couple of technologies compensating each other’s weakness. The new system is called mmWave edge cloud (MiEdge) henceforth. To facilitate MiEdge, the second main goal of the project is to develop a new cellular network control plane in which context information (location,  traffic, classes of applications, etc.) of users are collected and processed to forecast traffic and users’ requests, in order to enable a proactive resource allocation. This novel control plane is called liquid RAN C-plane, since the services and connections can follow users like a liquid. Lastly, the users or application providers orchestrate MiEdge to create a user/application centric 5G network that supports both eMBB and mission-critical applications. In summary, MiEdge project will develop a feasible 5G ecosystem by combining MiEdge, liquid RAN C-plane, and user/application centric orchestration. The project will contribute to the standardization of mm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Artificial Life-like Processive Systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Toroidal processive enzymes (e.g. enzymes/proteins that are able to thread onto biopolymers and to perform stepwise reactions along the polymer chain) are among the most fascinating tools involved in the clockwork machinery of life. Processive catalysis is ubiquitous in Nature, viz. DNA polymerases, endo- and exo-nucleases and; it plays a crucial role in numerous events of the cell’s life, including most of the replication, transmission, and expression and repair processes of the genetic information. In the case of DNA polymerases the protein catalyst encircles the DNA and whilst moving along it, make copies of high fidelity. Although numerous works have been reported in relation with the synthesis of natural enzymes' analogues, very few efforts have been paid in comparison to mimic these processive properties. It is the goal of this proposal to rectify this oversight and unravel the essential components of Nature’s polymer catalysts. The individual projects are designed to specifically target the essential aspects of processive catalysis, i.e. rate of motion, rate of catalysis, and transfer of information. One project is aimed at extending the research into a processive catalytic system that is more suitable for industrial application. Two projects involve more farsighted studies and are designed to push the research way beyond the current boundaries into the area of Turing machines and bio-rotaxane catalysts which can modify DNA in a non-natural process. The vision of this proposal is to open up the field of ‘processive catalysis’ and invigorate the next generation of chemists to develop information transfer and toroidal processive catalysts. The construction of synthetic analogues of processive enzymes could open a gate toward a large range of applications, ranging f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New phytogenic product line for pig production' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

In EU, the use of antibiotic growth promoters (AGP) in animal nutrition came under discussion due to cross-resistances. One of the most prospective alternatives forage's is a photogenic feed additive like herbs, spices and essential oils. With this CRAFT-project, the goal is to establish an innovative photogenic product line for pig production for a complete replacement of Gap's without any economical loss. The objective is to define, analyse and test herbal combinations to develop new product line for sows, piglets and fattening pigs. This innovative approach will provide several benefits in relation with health and nutrition: Achieving the same results as Gap's in production Para; No cross-resistances and resistances of animals against therapeutic antibiotics Better digestibility, reduced environment ional burden of animal production Reduction of soil pollution with antibiotics and not digested minerals (phosphorous); less ammonia in stall and slurry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Diplomacy Practices post-Lisbon: Adding Value through Cooperation' to be submitted under Horizon 2020.

assistant: **Abstract**

“European Diplomacy Practices post-Lisbon: Adding Value through Cooperation” (EuroDipl) aims to assess the impact and significance of new European diplomatic practices in third countries between the EU and its member states after the ratification of the Lisbon Treaty (2009). It asks how, if at all, increased European cooperation in third countries has impacted European foreign policy-making. In doing so, the project seeks to suggest ways in which the the effectiveness and legitimacy of the emergent European diplomatic system might be strengthened, especially in times when changing strategic and geopolitical contexts challenge Europe’s role in the world. The EuroDipl objectives are to 1. contribute to the conceptual, theoretical and methodological innovation in studies of European diplomatic practice, 2. explain the impact of post-Lisbon European diplomatic practice on European foreign policy, and 3. improve the cross-fertilization between policy practice and academic research. Those objectives will be achieved through a mixed-methods approach that combines a mapping of diplomatic practices via a quantitative social network analysis (WP1) with a qualitative comparative case study design to investigate the impact of European diplomatic practices (WP2). These research activities will be enriched by regular policy influence and public engagement activities (WP3) and training (WP4). EuroDipl offers an innovation to the study of European diplomatic cooperation and best practices in bringing research and practice together. It advances the career of the researcher through professionalisation (data management, communication strategy, project management) and methodological training. The University of Bristol and its School of Sociology, Politics and International Studies (SPAIS),