RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Politics, Economics and Global Governance: The European Dimensions' under Seventh Framework.

assistant: **Concept**

The long-standing US-EU partnership and dominance of a range of international institutions (IMF, World Bank, Security Council, etc.) is rapidly breaking down under the impact of shifting interdependencies and power relationships.  In this sense, global economic governance is at a crucial crossroads.  If a more complex and multi-polar world is now emerging, interwoven with bilateral agreements and a proliferation of regional efforts of uncertain outcome and dimensions, it is unclear how co-operation will be organised in the future and by whom. Global economic governance is riddled with worrisome uncertainties, yet this offers clear opportunities for an alliance between scholars pushing the bounds in terms of analysis, and EU policy entrepreneurs in terms of action. Europe must play a major part in the reform and reinforcement of global governance mechanisms, but in order to do so the EU requires a clear definition of its self-interest, a correspondingly clear sense of purpose and objectives, and the internal coherence and institutional capacity to exercise leadership. Now is the time for Europe to project a vision of how the global system should evolve, and to act. The project begins with five research domains: i) macroeconomic adjustment and governance; ii) the integration of markets for finance and investment; iii) the integration of markets for trade in goods and services; iv) migration and the mobility of labour; v) environmental governance.  hese are questions where a combined analysis by political scientists and economists is necessary if workable and real-world policy solutions are to be developed and prevail. Ultimately, the legitimacy of global governance depends on input and representation in the decision-making process of global governance, and on the output o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unraveling huntingtin function in cortical and striatal human development' (2014-2020).

assistant: **Innovation**

Huntington's disease (HD) is a rare neurodegenerative autosomic dominant disorder that causes severe motor dysfunction and cognitive deficits. Although HD main symptoms are manifested at mid-life, increasing evidence suggest that early neurodevelopmental defects may contribute to the late pathology. HD is a monogenetic disorder caused by a CAG repeat expansion inside the huntingtin gene (Htt). The functional role of Htt has been widely studied as a pro-survival anti-apoptotic factor, a regulator of vesicular trafficking along microtubules, a transporter of proteins between nucleus and cytoplasm, and a transcriptional role, however it’s main role in the brain during development and later adulthood is still poorly understood.Recently, genetic mouse models have shown that the loss of huntingtin from the brain at an early stage of development results in mitotic neural progenitor defects that disrupt cell fate in the cortex. In addition, the same study showed that loss-of-function of huntingtin specifically in early born neurons showed neuronal migration and neuronal dendritic arborization defects. However, to date, no studies have addressed and dissected the different roles of the human huntingtin protein in human cortical and striatal development specifically in different cell populations, or the effects of early phenotypes caused by loss-of-function of huntingtin in the late neuronal function.             Here, I will study and dissect the function of human huntingtin during human development using human pluripotent stem cells (PSC) differentiated towards cortical and striatal neurons. Through this project I will generate several conditional knock out and full knock out human PSC lines to remove Htt expression specifically from different neuronal cell populations. Overall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Comparative embryonic stem cell research in mammalians' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The PartnErS project is aimed at creating a mutually beneficial training and transfer of knowledge program between a Hungarian SME and a Danish and a Thai academic institution. The scientific and industrial aim is to generate new comparative information on the generation and maintenance of embryonic stem cells (ESCs) in mouse, pig and human and on their differentiation towards the neural lineage. The PartnErS project links research activities in different mammalian systems, including murine, porcine and human, and in SME and Academia. Training and transfer of knowledge activities are structured to assure the maximum efficiency in developing and exchanging the new standards between industry and academia and to expose the participating researchers to different environments and schools of thoughts. This is expected to be highly beneficial for their individual career development. The project is aimed to have an impact on the European Health sector. The main impact of the project is expected as integrating efforts in stem cell biology and cell therapy between industry and academia for long term collaboration. Furthermore, direct outcome of the project is expected from better stem cell differentiation protocols in mouse, pig, and human, with potential applications in human regenerative medicine and tissue engineering fields and, beyond it, in pharmaceutical industry and agriculture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Simulation of elastic die forming process for 3 dimensional parts' (1998-2002).

assistant: **Concept**

Most of the components of a plane are manufactured by stamping on flexible die press:- Fluid cell machine- Rubber pad machine compared to the classic deep-drawing, this process is more economic in term of material, operational time and personnel. However, the phase of preparation of the tools represents a complex task increasing the time of setting to the production. Moreover, the manual corrections necessary on the often complex parts increase the cost of these parts. The SEDF 3D envisaged research represents a new step forward in the methodology to modelize and simulate the process of elastoforming parts.The general goal is to create a simulation method allowing:- To improve general elastoforming process.- To facilitate the introduction of the technique of simulation into the fields of production by offering much faster method and tool (using analytical algorithms) and easier to implement (functioning on a PC).- To reduce the production costs of the tools design.- To reduce the manual corrections on the parts.- To improve the modeling of the rubber pads.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Renewables for clean energy buildings in a future power system'.

assistant: **Objectives**

RES4BUILD will develop renewable-eneRRES4BUILD develops renewable energy-based solutions for decarbonising the energy used in buildings. The approach of the project is flexible, so that the solutions are applicable to a wide variety of buildings, new or renovated, tailored to their size, their type and the climatic zones of their location. In the heart of the solution lies an innovative multi-source heat pump with a cascading configuration, including a magnetocaloric (bottom cycle) and a vapour compression heat pump (top cycle). The heat pump will be combined with other technologies in tailored made solutions that suit the specific needs of each building. These technologies will be selected on a case by case basis from a mix of standard equipment available in the market and from innovative components that will be specifically explored within the project. The innovative technologies include innovative collectors that integrate in one panel photovoltaic cells and solar thermal energy collectors (PV/T) and borehole thermal energy storage (BTES). For all solutions, advanced modelling and control approaches will be developed and will be integrated in a Building Energy Management System, allowing the users to select their objectives and to optimise the use of the system accordingly, allowing the activation of demand response and the exploitation of the full value of smart appliances and smart charging of electric vehicles. The project adopts a co-development methodology, where the end-users and other relevant stakeholders are engaged in an interactive process, where a RES$BUILD system is designed for their buildings with their active participation. In parallel, a full life cycle assessment and life cycle costing analysis will be carried out, showing from an early stage the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Trafficking in Women, Citizenship and Governance in Enlarged Europe', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This research proposal addresses the topic of trafficking in women from Eastern to Western Europe for the sex sector. The hypothesis advanced is that in contemporary Europe the issue of trafficking in women is inseparably linked to the process of the const ruction of European citizenship. This hypothesis is tested through two overlapping and complementary perspectives. On the one hand, the project points to the gendered and racialized coding of the European citizenship in the making and thus to the mechanism of hierarchization it installs. On the other, it examines the claims to mobility and inclusion of and apos; trafficked and apos; women and interprets them as demands of citizenship that challenge the boundaries of institutional coding of European citizens hip. Trafficking in women is a site, I suggest, where it is possible to examine the struggle over belonging and citizenship in the enlarged European community.This struggle is commonly concealed by current conceptualization of trafficking as a criminal activity and of women as victims. In order to broaden the analytic framework within which trafficking is commonly researched, this project develops an interdisciplinary study located at the intersection of Gender Studies, Cultural Studies and Political Sciences. Moreover, as to investigate the complexity of trafficking across discursive and material terrains, in develops a methodology that rests on three main discursive categories: women and apos;s narratives, representation and policy analysis.The research engages Priority 7 of the Work Programme and contributes to the knowledge- based society in Europe by broadening the state-of-art of research areas on gender, citizenship and governance (i.e. Research Areas 4, 6 and 7). By paying particular attention to the hierar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DESIGN OF COMPRESSOR AIR INLET PROTECTION FOR ELECTRICAL ECS' to be submitted under Seventh Framework.

assistant: **Abstract**

This proposal responds to the call JTI-CS-2012-1-SGO-02-040, in the Clean Sky Joint Undertaking included in the frame of the European FP7. This call is made for the design of a filtration system for electrical ECS (Environmental Control System) packs.Traditional ECS packs take the air from the engine through the bleed system. Therefore, some previous filtration is performed, since the air has gone through several stages of the engine compressor. Contrary, electrical ECS packs capture directly the air from the atmosphere via the scoop air inlet located on the belly fairing of the aircraft. Consequently, pollutants can be ingested by the scoop and therefore be introduced in the compressor of the electrical ECS if the air inlet is not properly cleaned.Most of aircrafts are equipped with traditional bleed ECS packs. Nevertheless, Boeing has incorporated such electrical no-bleed systems on the Boeing 787. Furthermore, applicability of actual filtration technology used on aircrafts and rotorcrafts highly exposed to harsh environment has to be further investigated and analyzed. Such systems are basically barrier filtration or inertial particle separation filters.Thus an air filtration system has to be developed during the project to accomplish the required removal of debris and pollutants at the compressor inlet. The aim of the filtration system is at the end to guarantee that the probability of loss of fresh air supply to the cabin stays in a non-relevant range, according to ECS safety.The methodology proposed combines theoretical (computational) and experimental techniques, and the knowledge in fluid dynamics by UPVLC with the industrial experience of LBFS in this particular area. Furthermore, applicants have wide experience managing performing EU funded projects and private
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering mechanisms of ciliary disease' in the context of a Seventh Framework call.

assistant: **Objectives**

Ciliopathies are pleiotropic diseases with a wide spectrum of human phenotypes. These include cyst formation in the liver and pancreas, respiratory disorders and a predisposition to diabetes and cancer. The pleiotropic nature of these disorders may reflect the many roles cilia play in physiology and signalling, highlighting the clinical importance of understanding their function in organ development and homeostasis. Despite the biological importance of cilia and decades of research, many aspects of cilia assembly and disassembly remain elusive. The earliest steps of cilia assembly involve conversion of the centrosome into a basal body, which anchors the cilia to the plasma membrane. Odf2 is one of the only proteins known to be important for this process, thus Ofd2 mutant cells lack cilia. During cell cycle re-entry primary cilia disassemble, the basal body dislodges from the plasma membrane and duplicates to serve as the mitotic centrosome. We recently identified Pitchfork, which functions in basal body-to-centrosome conversion and regulates embryonic patterning. The overall aim of this proposal is to better understand the cellular and bio-molecular mechanisms underlying ciliary disease. We will conditionally delete Odf2 and Pitchfork during embryogenesis and organogenesis. This will reveal the different requirements for the process of cilia assembly and disassembly in embryonic development, organ formation and homeostasis. The phenotypes will be analyzed at all levels of complexity. Subcellular imaging and identification of protein interaction partners will uncover the molecular basis of cilia assembly and disassembly. In summary, this project will decipher mechanisms underlying a wide spectrum of human ciliary disease and will open new avenues of clinical research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'TRAINING IN TRANSLATIONAL PROTOCOLS FOR MINIMAL INVASIVE DIAGNOSIS AND THERAPY IN PANCREATICO-BILIARY CANCERS'.

assistant: **Objectives**

The overall aim of the project is to strengthen the strategic partnership of the University of Medicine and Pharmacy Carol Davila Bucharest (UMFCD), Romania, one of the Widening countries, with two internationally-leading counterparts at the EU level (Region H - Copenhagen University Hospital Herlev, Denmark and University College London, UK), to enhance networking activities among these institutions and to combine their skills and competences in the field of minimal invasive endoscopic interventions in pancreatico-biliary diseases. Translated expertise, in the form of training and educating early-stage researchers (ESR) in the field of minimally invasive endoscopic interventions is needed to increase the number and quality of innovative services at UMFCD and its clinical affiliated hospitals. The proposal is the result of a long-standing collaboration and joint multicentric research projects performed by the partners of the consortium. Thus, in the past 20 years, there was a sustained clinical research activity in the field of minimally invasive endoscopic procedures, supported by various national and international grants of the key persons involved in the TRIP proposal. One of the key WPs of the TRIP proposal is represented by a multicentre protocol for a research project on pancreatic organoid cultures derived from endoscopic ultrasound guided fine needle biopsy (EUS-FNB) specimens with consequent pharmacotyping, used for personalized therapy of pancreatic cancer patients. The project partners will thus transfer their expertise to UMFCD with an emphasis on PhD students and ESRs. This knowledge transfer and capacity building will be achieved through joint research activities and academic collaboration, enhanced staff mobility, education and training activities, worksh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Medical Digital Twin for Aneurysm Prevention and Treatment' (MeDiTATe).

assistant: **Concept**

MeDiTATe aims to develop state-of-the-art image based medical Digital Twins of cardiovascular districts for a patient specific prevention and treatment of aneurysms. The Individual Research Projects of the 14 ESRs are defined across five research tracks:(1) High fidelity CAE multi-physics simulation with RBF mesh morphing (FEM, CFD, FSI, inverse FEM)(2) Real time interaction with the digital twin by Augmented Reality, Haptic Devices and Reduced Order Models(3) HPC tools, including GPUs, and cloud-based paradigms for fast and automated CAE processing of clinical database(4) Big Data management for population of patients imaging data and high fidelity CAE twins(5) Additive Manufacturing of physical mock-up for surgical planning and training to gain a comprehensive Industry 4.0 approach in a clinical scenario (Medicine 4.0)The work of ESRs, each one hired for two 18 months periods (industry + research) and enrolled in PhD programmes, will be driven by the multi disciplinary and multi-sectoral needs of the research consortium (clinical, academic and industrial) which will offer the expertise of Participants to provide scientific support, secondments and training. Recruited researchers will become active players of a strategic sector of the European medical and simulation industry and will face the industrial and research challenges daily faced by clinical experts, engineering analysts and simulation software technology developers. During their postgraduate studies they will be trained by the whole consortium receiving a flexible and competitive skill-set designed to address a career at the cutting edge of technological innovation in healthcare. The main objective of MeDiTATe is the production of high-level scientists with a strong experience of integration across academic,