RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'In-Touch: Implementation of a person-centered palliative care iNtervention To imprOve comfort, QUality of Life and social engagement of people with advanced dementia in Care Homes' (In-Touch), addressing dissemination and exploitation.

assistant: **Impact**

Challenge. Caring for the increasing numbers of people across Europe with advanced dementia and palliative care needs who live in care homes is difficult and demanding. People with advanced dementia can be immobile, non-verbal and unable to take part in day-to-day activities. They can be unsettled or agitated, with low quality-of-life and elevated levels of discomfort. Family members can find it difficult to connect meaningfully with their relative and are anxious about the future. Care staff can struggle to provide care other than for basic needs such as feeding, toileting and skin care. Solution. An ethically sound solution which advances beyond the science, providing both care ‘in-the moment’ (using Namaste Care) and planning for future care needs (using the Family Carer Decision Support ‘Comfort Care’ approach). We call this the In-Touch intervention. Plan. To deliver a cross-country cluster randomised controlled trial of the In-Touch intervention in 56 nursing care homes across 7 countries to determine its effect on comfort, social engagement and quality of life. This is supported by 9 work packages ensuring that: the intervention is robustly planned and contextualised for different country settings; there is understanding of how it is delivered, and what people experience and ethically value about the intervention; the cost-effectiveness is understood; we have effective plans to transfer knowledge about this intervention if it is successful.  Impact. This intervention could herald a major change in the way that care for people with advanced dementia, in the palliative phase of their illness, is provided across Europe. People with advanced dementia should have better quality of life as they approach death, improved engagement and reduced social isolation. Care staf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'From Legacy Systems to Services in the Net'.

assistant: **Objectives**

The evolution of the Internet and wireless communication, the pillars of the so-called e-Economy", keeps inducing more challenges to the way companies and organisations operate and need their processes supported through software systems.  More and more, the day-to-day functioning of our society, as a whole, has to rely on a network of infrastructures controlled by software systems.  However, in order to compete in this "new-Economy", most organisations have to rely on what are called "legacy systems": systems that have been constructed without having the ability to change as a first-class design-goal.Leg2Net focuses on the methodologies and technologies that address the challenges that companies and organisations are facing for evolving their systems to operate and compete in the e-Economy:  How to create the new generation of applications that will operate in Net-based environments?  How to evolve legacy systems and promote business processes in an economy dominated by the need to offer and integrate, on demand, new services?  How to operate systems that are becoming progressively heterogeneous (multi-platform, multi-vendor) and complex (relying on intricate interactions over often unreliable communication networks)?"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Bioremediation of toxic redox-active food residues by antioxidative food components'.

assistant: **Concept**

Foreseen ResultsThe results of the research will define the antioxidants that should be preferably conserved or added when handling and storing fruits and vegetables or other foods, or when converting them to industrial products such as juices, dried, precooked or deep-frozen products. This insight provides improved possibilities for the production of so-called functional foods; foods with beneficial health effects.Toxic redox-active food residues such as nitroaromatic and quinone-type of food components can originate from pesticide use and/or can be present in food because they are natural food constituents and food conservants. An intrinsic property of quinones and aromatic nitrocompounds is the possibility of their biochemical reduction in organisms, often resulting in formation of cytotoxic products that give rise to oxidative stress through redox-cycling. Redoxcycling is a toxic process in which, catalyzed by flavin-dependent enzymes, quinones and nitroaromatics may undergo one or two electron reduction steps, leading to the formation of intermediates that react with molecular oxygen to give reactive oxygen species. The production of reactive oxygen species causes toxic phenomena known as oxidative stress, resulting in lipid peroxidation, oxidation of important thiol groups in enzymes and proteins, enzyme inactivation, DNA modification and cell death. The bioreduction of nitroaromatics gives also rise to the formation of hydroxylamines and nitroso derivatives which may react directly with DNA or with hemoglobin causing methemoglobinemia. In addition, the semiquinones formed can give rise to DNA intercallation.Bioremediation against the toxic adverse health effects exerted by the products resulting from bioreduction of the redox-active food components can be exerted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sulfite export mechanisms as a therapeutic vulnerability in KEAP1-deficient lung cancer' (SulFex).

assistant: **Concept**

Non-small cell lung cancer (NSCLC) harboring KEAP1 mutations is associated with a poor prognosis and resistance to conventional therapies. However, KEAP1/NRF2 dysregulation induces metabolic reprogramming, which can be exploited for therapeutic benefit. Our research has uncovered that these cells produce and accumulate high levels of sulfur-containing compounds, a metabolic vulnerability in these cancer cells. To maintain cellular homeostasis and survival, these cells rely on the active export of the toxic metabolite sulfite, presenting a unique therapeutic opportunity.During our ERC Consolidator project, we identified the solute carrier protein SLC26A6 as a transporter of selenite and related anions, including sulfite. We then developed SulfExstatin1, a first-in-class small molecule inhibitor that effectively inhibits human SLC26A6 and blocks sulfite export. By targeting this essential detoxification mechanism, SulfExstatin1 selectively impairs the growth and survival of KEAP1-mutant NSCLC cells while sparing normal cells, thereby minimizing off-target toxicity. Our preliminary studies demonstrate strong efficacy in cell culture, underscoring the potential of this approach as a novel treatment strategy for this aggressive cancer type.Building on these findings, we propose to establish an innovative approach targeting sulfite metabolism in KEAP1-mutant NSCLC and other cancer subtypes with similar metabolic dependencies. This project will involve optimizing SulfExstatin1 and related inhibitors, characterizing their mechanisms of action, and evaluating their efficacy in biochemical assays and in vivo models. Furthermore, we plan to establish a patent framework to protect the intellectual property arising from this project. Ultimately, our goal is to translate this metabol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chemistry of Platinum Group Metals' (CHemPGM).

assistant: **Innovation**

The CHemPGM project is a joint initiative of 7 expert organizations from the fields of chemistry, engineering, mining, metallurgy and materials science, designed to conduct fundamental research regarding the chemistry of platinum group metals (PGMs) and utilize the obtained knowledge to improve and secure the PGMs value chain. Specifically, the project aims i) to establish fundamental knowledge regarding the chemistry of the PGMs, their reactions and complexation with other metals and chemical compounds, and the corresponding reactivities during leaching, separation and recovery processes; ii) to gain a complete understanding of the mechanisms associated with the above-mentioned processes, during the utilization of secondary materials to extract PGMs and incorporate them into new materials and processes such as nanomaterials, catalysis and CO2 capture; iii) to create knowledge, provide expertise and educate the public. This will lead to the upgrading of existing processes and the development of new ones, aligned with sustainable principles, to ensure a circular operation model of the relevant industries. Through the involvement of universities, RTOs and SMEs, CHemPGM is backed by a well-rounded team, with multiyear expertise in the relevant fields, capable to deliver high-quality results regarding the project objectives. The consortium approaches the challenge from a multidiscipline aspect and proposes a balanced number of secondments alongside trainings, workshops, seminars and events that guarantee a cross-sectorial synergy among them. As a result, CHemPGM will broaden the expertise of the organizations, contribute to the advancement of the secondees and enhance the potential for innovation to its stakeholders and those inter-related with it. Overall, the methodology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering the structure and functions of the soil microbiome of exotic plantation of a changing world (EXOFUN)' under Horizon Europe.

assistant: **Concept**

Over the centuries, exotic trees have been planted worldwide for the rehabilitation of degraded lands and to obtain financial benefits from wood, paper production, tannins, ornamental assets. However, despite being evolutionary naïve to the new environment outcompete the locally adapted native plants in resource acquisition, displace the native vegetation and may become invasive species. While the influence of exotic plantations on native vegetation structure and community composition is well documented, surprisingly, much less is known about how exotic tree plantations have altered the structure and function of the soil microbiome. Although soil conservation is integral for the achievement of socio-ecological sustainability, a comprehensive study focused on the biogeographical comparisons of cyclic linkages between exotic plants and soil microbes and its influence on the multiple ecosystem functions is lacking. This is urgently needed to better understand the impacts of exotic plantations on biodiversity and function along with interaction with other global change drivers such as climate change. Using Eucalyptus globulis and Pinus pinea as our model exotic tree species, the main aim of EXOFUN is  to understand the influence of exotic plantations on the structure and function of the soil microbiome at a cross-continental scale by combining observational studies and greenhouse experiments. How do exotic tree plantations influence carbon sequestration, soil biodiversity maintenance, and the capacity of ecosystems to response to climate change compared with native forests? In the current UN-decade of ecosystem restoration, the outcomes of this project will help to understand that to what extent the plantation of the exotic species be allowed, or should we completely replac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Low energy cure laminates for high energy absorption applications in sports goods and other safety critical areas' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Conventional polyester and phenolic laminates provide affordable composites products but have low impact resistance. Advanced aerospace epoxy based composites show dramatic impact resistance under high profile crashes such as occur in F1 racing but are too costly to purchase and process for general use. The proposed project will develop toughened laminate materials and low cost construction technology to enable specialist SME designers and molders to produce the next generation products with improved crashworthiness at a competitive price. Innovation in solvent free matrices and novel reinforcements will eliminate the need for slow, high capital cost autoclave processing and costly tooling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Probability distribution of fatigue strength of rotor blades'.

assistant: **Innovation**

OBJECTIVES OF THE PROJECT The fatigue strength of rotor blades show some variation, among others due to the inherent scatter of the material properties. To take into account this uncertainty a safety factor for fatigue strength is prescribed in design codes. Likewise an additional test load factor has to be applied in full scale blade testing. To determine these factors in a rational manner the fatigue strength distribution of rotor blades is a prerequisite. As this distribution is not available at the moment the corresponding factors are determined empirically and a lot of uncertainty concerning the values used nowadays is present. For this reason the main objectives of this project are: - acquisition of a deeper understanding of the blade to blade variation and determination of the statistical distribution functions of the fatigue strength of rotor blades; - determination of the correlation between the measured fatigue strength of rotor blades and coupon data. Besides, the following additional objectives are defined: - formulation of a more generic methodology to determine the fatigue strength distribution of rotor blades based on the above mentioned correlation; - definition of the test load factors to be applied in a full scale blade fatigue test as function of the number of tests to be performed; - transfer of specific knowledge on the application of statistical techniques to characterize the fatigue strength of blades to certification bodies. TECHNICAL APPROACH To achieve the project objectives the blade to blade variation in fatigue strength will be quantified by testing a large number of test specimens with a realistic structural design. This will either be commercial available small scale blades eventual modified for this project or test specimens special devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Researchers' Night in Sweden - ForskarFredag 2011'.

assistant: **Innovation**

Researchers’ Night in Sweden, ForskarFredag (Researchers´ Friday), FF, will consist of 15 events in 25 cities, geographically dispersed across Sweden. The project aims to bring the general public face-to-face with researchers. FF will take place on 23rd September 2011 and will be coordinated by VA (Public & Science), as in 2006-2010. Local event organisers will be universities, science centres, municipalities and a regional council. Both the coordinator and the event organisers have extensive links with researchers in industry and academia across a wide range of disciplines.Innovative and exciting activities will be offered at all events, creating a relaxed and festive environment for the public and researchers to meet and talk. Fun, hands-on and interactive activities as well as informal dialogues on topical issues will attract the broadest public possible. Communication and European cooperation in research will be highlighted.Events will be planned locally and brought together under the national FF umbrella, including a nationwide mass experiment for school classes in connection with the events and a joint website. This will ensure a unanimous FF message: “Researchers are ordinary people with extraordinary jobs”, as well as common objectives and a common identity through the FF logo and other marketing materials.The estimated total number of visitors is at least 22,350. Live media reports and news items about the events are expected to reach approximately 2.5 million Swedes (over a quarter of the population). A coordinated awareness campaign will be implemented from early on. Impact will be assessed through measuring visitor numbers and the extent of media coverage, and through questionnaires for both researchers and the visiting public.Findings from the impact assess
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Characterising the role of microbial behaviour and nutrient exchanges in coral symbioses'.

assistant: **Objectives**

Coral reefs are the most diverse marine ecosystems, but are currently threatened by anthropogenic stressors that disrupt the relationship between the coral host and its microbial symbionts (i.e., endosymbiotic microalgae and bacteria). While these symbionts are fundamental to coral health, corals do not generally transmit them to their offspring, who have to acquire them from the environment. Despite the critical roles of microbial symbionts for coral health, we still do not know how they find and colonise their coral hosts, which key compounds are exchanged between the various partners once in symbiosis, and to what extent bacterial symbionts contribute to coral growth.My previous research has revealed the importance of chemotaxis in other marine symbioses, a behaviour allowing microbes to find their host by homing in on the chemical cues it produces. Building on my previous research and preliminary data, I hypothesise that coral symbionts also use chemotaxis to find and colonise corals. Using a unique combination of cutting-edge approaches, this project aims to characterise the onset and functional consequences of coral-microbe symbioses. More specifically, it will:(1) identify the chemical cues underpinning the recruitment of coral symbionts, using analytical chemistry approaches and in situ chemotaxis assays that I previously developed;(2) determine how key bacterial symbionts colonise their coral host, through genetic engineering of the bacterial symbionts with live imaging and microscopy;(3) characterise the chemical exchanges between bacteria, microalgae, and their coral host, by combining co-culture assays, omics, and high-resolution secondary ion mass spectrometry.By deciphering the chemical language of coral symbiosis, this project will reveal biological proce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Satellite-based Observation of Land  Infrastructure Deformations' (SOLID) targeting Horizon 2020.

assistant: **Abstract**

The overall objective of our project is therefore to design, build and run an innovative end-to-end service for continuous and automatic GNSS deformation monitoring based on a new generation of low-cost GNSS receivers (Global Navigation Satellite System, including GPS and Galileo), prototypes of which are currently being developed by GReD and selected partners.The objective of the feasibility study is the development of a business plan to confirm the potential market and benefits, identify application fields and to estimate the investments needed for designing, building and running an operative end-to-end monitoring service. The business plan will also consider intellectual property management, sales channels to reach the market and economic metrics for the service pricing and delivering.The overall activities of the project are foreseen to be completed within 6 months.