RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A cost-effective production process to open worldwide the cultured meat market'.

assistant: **Concept**

Livestock farming is putting a significant pressure over the environment. Globally, the livestock sector uses 70% of the arable land and emits 15% of all human-induced greenhouse gas (GHG) emissions. If an alternative to the current meat production systems is not found, the situation would only worsen given the fact that meat demand is expected to increase globally by 73% by 2050.Livestock environmental impact, together with animal welfare issues and meat content on saturated fats, is pushing the EU population to cut-down meat consumption and shift to meat substitutes (tofu, tempeh…). For example, 38% of the French, 35% of the Dutch or 17% of the Spanish, are actively choosing to eat less meat. The main reason to take that decision is animal welfare (30%) followed by environmental concerns (22%). However, this choice reduces their meal options and makes it harder to follow a well-balanced diet since meat is an excellent source of high quality proteins and the only dietary source of vitamin B12 (an essential nutrient). Encouraged by this issue, our SME Greenfoods Network started the project CULTUREDBEEF, aimed at obtaining and at marketing beef meat from the culture of dairy cattle muscle cells. To do so, we have developed an innovative and cost-effective production process that will allow us to be the first company worldwide to place in the market cultured beef burgers at a competitive price.Thanks to our solution, the EU population will be able to eat high-quality and environmentally-friendly beef meat, since our product (i) doesn’t imply animal slaughtering, (ii) needs 99% less land, 82-96% less water and emits 78-96% less GHG emissions than conventional meat and (iii) contains 60% less saturated fats than conventional beef meat. We will launch it to the Spanish marke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Solar Energy Enabled for the World by High-resolution Imaging'.

assistant: **Concept**

THE GOALWe will derive new and fundamental insight in the relation between nano-scale structure and the performance of 3rd generation solar cells, and determine how to apply this in large-scale processing.THE CHALLENGESWe currently have a superficial understanding of the correlations between structure and performance of photovoltaic heterojunctions, based on studies of small-scale devices and model systems with characterization techniques that indirectly probe their internal structure. The real structures of optimized devices have never been “seen”, and in devices manufactured by large-scale processing, almost nothing is known about the formation of structures and interfaces.THE SCIENCEWe will take a ground-breaking new approach by combining imaging techniques where state of the art is moving in time spans on the order of months, with ultrafast scattering experiments and modelling. The techniques include high resolution X-ray phase contrast and X-ray dark-field tomography, in situ small and wide angle X-ray scattering, resonant scattering and imaging and time resolved studies of charge transport and transfer. To relate our findings to device performance, we will establish full 3D models of charge generation and transport in nano-structured solar cells.THE FOCUSSolution cast solar cells is the only technology that promises fast and cheap industrial scaling, and it is consequently the focus of our efforts. They require a tight control of processing conditions to ensure that the proper nano-structure is formed in the photoactive layers, with optimal contacts to charge transport layers and interfaces. The prime contenders are non-toxic polymer and kesterite solar cells.THE IMPACTOur results may advance 3rd generation, solution-cast solar cells to meet the “unification chall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Concerted action for coordination of TERI-Terrestrial ecosystems research initiative' in the context of a Fourth Framework call.

assistant: **Objectives**

To ensure synergy between the European ecosystems research projects - to organize thematic meetings and workshops for the participants of ecosystems to improve interaction between projects - to provide a forum for discussing ecological theory and experimental research in order to provide the scientific framework for future research and environmental monitoring activities - to stimulate the development of environmental models - and in particular models suited to assist in the difficult question of generalising from limited experiments (scaling-up).The research on global change in terrestrial ecosystems is organized as a special part of the Environment and Climate programme and is described in the TERI document. It is proposed to establish a concerted action creating a framework for promoting cooperation between the projects on terrestrial ecosystems funded by the programme. It is the aim of the TERI coordination to ensure the optimal synergy between the terrestrial ecosystem research projects. This is organized by bringing the groups working on each theme together to discuss different approaches, to plan joint experiments and for utilising the transects in the most efficient way. Promoting the integration of results into models and scenarios of future changes is also part of the concerted action. The TERI coordination contains an organizational structure at three levels that will keep the project coordinators informed about other proJects and show how far the TERI objectives are fulfilled. The activities of the concerted action include contact and progress meetings on the projects level for each theme. Some council meetings are planned at selected sites for the development of methodology and joint experiments. TERI coordination is also planned to organize, towards the en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a solar distillation wastewater treatment plant for olive oil mills' (SOLARDIST).

assistant: **Concept**

Scientific objectives and approach:The main objective of the SOLARDIST project is the treatment of the liquid waste generated in small olive oil mills, many of them with no economically adequate treatment system, by means of a combination of a solar distillation process and constructed wetlands. In addition to this, the organic solid waste generated during the process of the olive oil, is proposed to be composted in order to provide an environmental friendly solution to this residue.Problems to be solved:Europe is the most important producer of olives in the world. A significant part of the olives harvested are processed to produce olive oil in several thousand of mills. These producers are mainly placed in the basin of the Mediterranean Sea (Greece, Italy, Spain, and other countries), and all of them with the common trouble of the wastewater generated in the process. Many of them are small and medium sized enterprises, without enough economical resources to afford expensive solutions for the problem of this wastewater. It is necessary to join forces and resources from all of them in order to find an economical and easy solution.Besides, a solid residue is produced within the olive oil production, which usually is burned or deposited in olive farms.Expected Impacts:The project SOLARDIST will have several positive impacts once it is conclude. On the one hand, the establishment of a solar distillation wastewater treatment system for SMEs olive mills in combination with a biological treatment like constructed wetlands would allow to eliminate the 98 % of its organic matter content, including phenols and polyphenolic compounds. As well as this, the reduction of the air pollution and odour generated from uncontrolled evaporation pools, due to the installation of the solar di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Effects of precipitation change on terrestrial ecosystems - a workshop and networking activity.' (EPRECOT), addressing dissemination and exploitation.

assistant: **Impact**

EPRECOT will organise a workshop on the effects of precipitation change on terrestrial ecosystems in order to bring together international research groups and experiences from precipitation related research.The ultimate goal of the workshop will be to faci litate future international research collaboration within the field between European researchers and researchers from the US and developing countries.The workshop will do this by evaluating our present knowledge on (i) the direct and indirect responses of terrestrial ecosystems to changes in the quantity and timing of precipitation, and (ii) how changes in water mediate ecosystem response to warming and elevated CO2. The workshop will include 4 main activities:1) present day state of the art" and knowledge will be summarised and synthesised based on past and present ecosystem scale research projects.2) future key research areas will be pinpointed by the use of ecosystem-models to generate hypotheses about the expected consequences of precipitation changes.3 ) gaps in knowledge and new research activities will be proposed through plenary discussions and a series of working group discussions.4) the results will be disseminated and distributed in a synthesis report, 2 scientific papers and a web-page summary."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms of Sirtuin-dependent regulation of immunity and leukemogenesis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Acute lymphoblastic leukemia, the most common pediatric cancer, originates in many cases from the malignant transformation of a developing Blymphocyte in the bone marrow. Understanding the mechanisms of B cell maturation and how their perturbation contributes to the onset of this pathology is essential for evolving improved strategies for those patients not responding to current therapies. Importantly, this project aims to discover novel mechanisms of B lymphopoiesis by studying the interplay between SIRT7, a Sirtuin family member critical for genome homeostasis, and PAX5, a transcription factor required for B cell development and to sustain B cell identity. Sirtuins play key roles in the maintenance of genome integrity under stress and their deficiency has been linked to the pathogenesis of cancer. Importantly, SIRT7 is highly expressed in developing lymphocytes yet their role in immune cells and its relationship with leukemia awaits further investigation. With this project, we will define SIRT7-dependent regulatory mechanisms of PAX5 protein turnover, its relationship with PAX5-associated transcriptional programs and how their functional interplay is abnormal in leukemic cells. Because PAX5 is found in haploinsufficiency in most of the cases of acute lymphoblastic leukemia of B-cell progenitors, the development of this project is highly significant to the society as it has the potential to generate novel approaches to restore PAX5 protein levels, with important implications for clinical interventions and the cure of this disease.


**Keywords:** B cell development, leukemia, chromatin regulation, protein turnover, transcriptomics, Sirtuin, PAX5
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Zero-carbon Industrial heat production by aMmonia water aBsorption heAt transformer' (ZIMBA).

assistant: **Concept**

Decarbonizing industry is the key challenge for 2050 to achieve the Net Zero ambitions. For this, one of the current pathways is the massive electrification of industrial processes in demand for low-temperature heat (up to 150°C) thanks to heat pumps. However, the electricity distribution companies have recently issued an alert: the grid development is insufficient to match the enormous future needs for electricity. In the coming decades, this will thus trigger tensions on the power grid and lead to priorization in the supply of electricity. Therefore, to alleviate electricity demand while meeting industrial needs, it is crucial to provide alternative technology, such as Absorption Heat Transformer (AHT), which has the potential to meet the demand for low temperature heat, from non critical and abundant energy sources such as industrial waste heat, with hardly any electrical use.With this objective of offering another option than vapor compression heat pumps, the ZIMBA project aims to develop and validate at TRL4, an innovative AHT system at 15 kWth and 110°C. It will be based on a novel water ammonia AHT technology improved by a two-phase ejector specifically designed in order to stabilize its performance and widen the range of its operating conditions, in particular under hot conditions.From the physical evaluation results obtained, scaling studies up to 500 kWth will be carried out by the consortium, composed of researchers and industrial manufacturers, in order to push for a design with practically no critical raw materials, easily maintainable and recyclable, and with only commercially available components for fast time to market. The integration of the system in the potential future energy market and the associated business models will be studied in order to ensur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dynamic adaptive microscopy for label-free multi-parametric imaging in biology and medicine'.

assistant: **Concept**

Optical microscopy constitutes one of the most fundamental paradigms in biological and medical imaging. However, significant challenges remain in regard to the application of optical microscopy to in vivo interrogations. First, the diffusing nature of light propagation in tissue due to random variations of the refractive index, limits in vivo microscopy to superficial depths; within only a few mean free paths (<1mm). Second the invasive nature of fluorescent proteins and probes, allows monitoring of only 1-5 events by spectrally multiplexing different fluorochromes; i.e. performance that is highly incompatible with the targets of functional genomics and proteomics.This proposal aims to develop the next step in optical visualization by addressing these two fundamental limitations of optical imaging, i.e. Depth and Contrast. To achieve this, DynAMic proposes a radically new concept for optical imaging of tissue based on ❶ developing real-time wavefront-shaping adaptive optics for making the performance of any optical system ideal and for the first time in Raman microscopy ❷ reaching tenfold deeper in tissue than conventional optical microscopy by compensating for the refractive index variations using  phase and polarization retrieval for inversing light diffusion and ❸ utilize advance image formation to improve the sensitivity and utilization of stimulated Raman scattering for multi-parametric label-free contrast that radically expands at least tenfold the number of labels concurrently retrieved from living systems, linking optical observation to functional proteomic requirements. The new optical imaging ability delivered in DynAMic will be applied to a first target application of ophthalmic imaging, also used as a window to the brain and devastating nervous disease detec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of striatum in selection of behaviour and motor learning - neuronal code, microcircuits and modelling' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The input layer of the basal ganglia, the striatum, plays a critical role in the control of motor behaviour and cognitive function. It serves as a filter for cortical and thalamic signals and takes part in determining which actions should be performed at a given instant. Our goal is to define the cellular and network organisation underlying decision-making by analysing the microcircuitry of subpopulations of neurons in striatum (interneurons and projection neurons) concerned with the control of different patterns of behaviour, and their input from cortex (pallium), thalamus and the modulatory inputs from dopaminergic, histaminergic and 5-HT neurons. The microcircuitry will be studied in slices of striatum with patch electrode recordings from three or more identified subtypes of neurons at the same time, while synaptic and membrane properties are investigated and also the synaptic response to the different input systems. Specific synaptic connections of the recorded neurons will be identified by electron microscopy and quantitative aspects of the connections of the different classes of neurons will be defined. Striatal neuronal activity will also be studied in behaving animals with multiunit neuronal recording in relation to defined motor behaviours utilizing several vertebrate model systems (lamprey, rodent and primate). The primary focus will be on striato-pallidal projections indirectly controlling motor programs at the brainstem/spinal cord level, rather than via the thalamo-cortical forebrain projections since these projections cannot as easily be interpreted. Neuronal function and synaptic interaction at the microcircuit level will be subjected to a detailed computer modelling based directly on the outcome of the experimental analyses. Plasticity underlying motor l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Adult articular cartilage has a limited capacity for repair and when damaged or injured, experiences a loss of function which leads to joint degeneration and ultimately osteoarthritis.  Biomaterials-based treatments have had very limited success due to the complex zonal structure of the articular joint,  problems with biomaterial retention at the joint surface and achieving integration with the host tissue while also maintaining load bearing capacity.  Stem cell therapies have also failed to live up to significant hype for a number of reasons including the challenges with achieving formation of stable hyaline cartilage which does not undergo hypertrophy.   Building on a wealth of experience in the area, we propose a solution. ReCaP will initially overcome the problems with traditional biomaterials approaches by utilising recent advances in the area of advanced manufacturing and 3D printing to develop a 3D printed multi-layered scaffold with pore architecture, mechanical properties and bioactive composition tailored to regenerate articular cartilage, intermediate calcified cartilage and subchondral bone.  Following this, and building on internationally recognised pioneering research in the applicant’s lab on scaffold-mediated nanomedicine delivery, this system will be functionalised for the controlled non-viral delivery of nucleic acids (including plasmid DNA and microRNAs) to direct host stem cells to produce stable hyaline cartilage at the joint surface and encourage the rapid formation of vascularised bone in the subchondral region. A new paradigm-shifting surgical procedure will then be applied to allow this system to be anchored to the joint surface while directing host cell infiltration and tissue repair, thus promoting restoration of even large regions of the dama