RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart INks as a standard TEsting tool for self Cleaning surfaces' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This action will explore the utilisation of photocatalyst indicator inks in a CEN standard for the rapid testing of the activities of various different self-cleaning surfaces, including: glass, tiles, paints, fabrics and concrete.  The formulations of all the inks will be given in the standard and so freely available. To date, no rapid screening method for assessing photocatalyst activity exists outside the use of such inks and ISO and CEN have no plans at present to introduce a standard based on these inks, although many members of the photocatalyst community and relevant ISO and CEN communities use them. The key project objectives are: i) prepare appropriate, different photocatalyst inks and typical photocatalyst samples based on glass, tiles, paint, concrete and fabrics for round robin tests, ii) conduct a series of round robin tests that identify the best inks and protocol for each very different coating substrate, iii) present the results and conclusions of the round robin tests to the relevant CEN committee (TC386) and use the feedback to improve the prepared draft standard and finally iv) have accepted by TC386 a final CEN standard on photocatalyst activity-measuring inks for subsequent processing and adoption by CEN via TC386. The proposal is fully supported by the chairman of CEN/TC 386 ""Photocatalysis"" and will address an important need, not yet covered by the current CEN/TC 386 group, namely the rapid assessment of activity using smart inks which can be also used in field tests. The proposal compliments the portfolio of CEN standards currently under development and the project consortium consists of 4 academic and 3 industrial partners, two of which are already active in the CEN/TC 386. The proposed standard ink test for self cleaning surfaces will deliver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synthesis of peptide imprinted nanoparticles and their integration to ELISA-like assay for the quantification of hepcidin' (PINP).

assistant: **Innovation**

The development of assays based on molecular recognition for measuring biomarkers is a critical task for the diagnosis and prognosis of pathologies. The present project aims at developing synthetic nanoparticles (NP) for the quantification of the peptide biomarker hepcidin (hep) which regulates iron homeostasis. A modern strategies for mimicking receptors consists of NPs produced by molecularly imprinted polymer (MIP) technology. MIPs are prepared by a template-assisted emulsion polymerization. After removal of the template, complementary cavities are exposed in the polymer. The target biomarker, hep, is a 25-residue peptide (hep25) present in urine and plasma, other N-terminus truncated isoforms such as hep20 and hep22 were also found in humans. It is known that the first 5 amino acids of the N-terminus of hep25 are essential for iron homeostasis while the role of other isoforms is still unclear. Given that the imprinting is more successful for short peptides only 2 crucial portions of the full length peptide are synthesized as templates which are also functionalized to impose a direction of imprinting. The precision of the template synthesis ensures a higher fidelity of imprinting during the NPs synthesis improving the molecular recognition. The goal of the project consist in designing an assay for the determination of serum and/or urinary hep, based on MIPs selective for hep isoforms and arranged in a pseudo-immuno assay format, further extended in sensitivity by the addition of fluorescent tags. At last, an evaluation of the assay with clinical sample is planned to be performed. The possibility of using nano-sized MIPs as plastic antibodies in ELISA-like assays has the obvious advantage of a potential widespread diffusion. The proposed ELISA-like assay with fluoresc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Options for Delivering Ecosystem-Based Marine Management' to be submitted under Seventh Framework.

assistant: **Abstract**

The overall aim of the ODEMM project is to develop a set of fully-costed ecosystem management options that would deliver the objectives of the Marine Strategy Framework Directive, the Habitats Directive, the European Commission Blue Book and the Guidelines for the Integrated Approach to Maritime Policy. This will be achieved by: (i) providing a comprehensive knowledge base to support policy for the development of sustainable and integrated management of European marine ecosystems; (ii) developing Operational Objectives to achieve the High-Level Policy Objectives set by the MSFD and the HD, and with reference to the proposed Maritime Policy; (iii) identifying Management Options (individual management tools and combinations of tools) to meet the Operational Objectives; (iv) providing a risk assessment framework for the evaluation of Management Options and to assess the risk associated with the different options; (v) conducting a cost-benefit analysis of a range of Management Options using appropriate techniques; (vi) identifying stakeholder opinions on the creation of governance structures directed towards implementation of the ecosystem approach, and to elaborate different scenarios for changing governance structures and legislation to facilitate a gradual transition from the current fragmented management approach towards fully integrated ecosystem management; (vii) documenting the steps necessary for the transition from the current fragmented management scheme to a mature and integrated approach, and providing a toolkit that could be used to evaluate options for delivering ecosystem-based management; and (viii) communicating and consulting on the outcomes of the project effectively with policy makers and other relevant user groups.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Supply Chain in Aeronautics, Needs for Research and Technological Development' in the context of a Fifth Framework call.

assistant: **Objectives**

To remain competitive, SMEs of the Aeronautic, Space and Defence industry need increasingly to innovate and internationalise. The community Framework Programme is an ideal mechanism for realising those goals. Nevertheless, SMEs face difficulties to participate, especially when they are mere subcontractors, deeply integrated in a supply chain.They need a special accompanying measure, with the support of their main contractors/large companies and a transnational network of consulting companies already involved in their development:- to identify main technological and market issues that can be addressed through the participation in the Community RTD programmes- to be assisted through coaching, workshops and thematic clusters to make emerge and present European RTD projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulatory genomics during Drosophila embryogenesis: dissecting enhancer-promoter interactions' to be submitted under Horizon 2020.

assistant: **Abstract**

In eukaryotes, the complex regulation of temporal- and tissue-specific gene expression is controlled by the binding of transcription factors to enhancers, which in turn interact with the promoter of their target gene(s) via the formation of a chromatin loop. Despite their importance, the properties governing enhancer function and enhancer-promoter loops in the context of the three-dimensional organisation of the genome are still poorly understood.My recent work suggests that (i) developmental genes are often regulated by multiple enhancers, sometimes located at great linear distances, (ii) the spatio-temporal activity of a large fraction of those enhancers remains unknown, (iii) enhancer-promoter interactions are usually established before the target gene is expressed and are largely stable during embryogenesis, and (iv) stable interactions seem to be associated with the presence of paused RNA Polymerase II at the promoter before gene activation.Building upon these results, we propose to advance to the next level in the dissection of enhancer-promoter interaction functionality in the context of Drosophila embryogenesis. Specifically, we will address three important questions: (i) What determines the specificity of promoter-enhancer interactions in a complex genome? (ii) Are enhancer-promoter interactions tissue-specific, and what are the drivers of this specificity?  (iii) Are all enhancer-promoter interactions functional, and how does the activity of an enhancer relate to the expression of the gene it interacts with?To this end, my group will apply an interdisciplinary approach, combining state-of-the-art methods in genetics and genomics, including novel single-cell techniques, using Drosophila embryogenesis as a model system. Our results will provide a unique view of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Disability, Discrimination and Linguistic Justice: A Human Variation Perspective' (HUMVAR) under Horizon Europe.

assistant: **Objectives**

HUMVAR is a project in applied ethics, and it adopts the framework of a particular disability model, the human variation model (HVM). The goal of HUMVAR is to advance research on the HVM, and it has three objectives: first, to provide a philosophical defense of the HVM. HUMVAR’s interpretation of the HVM shows that an important aspect of disability disadvantage is caused by exclusive environments. This causation story grounds societal responsibility and justifies the provision of more accommodating environments —the favored policy response of social models of disability. The first objective defends this interpretation against the challenge that social models of disability cannot justify the policy of environmental reconstruction. HUMVAR’s second objective is to redefine the problem of disability that the model articulates as a special case of discrimination (discrimination-as-human-variation). Discrimination-as-human-variation is a revisionary account of the HVM, as the original version of the model aims to be an alternative to discrimination-based approaches to disability. This revisionary interpretation explores that disability-as-human-variation is a form of ableism. The third objective is to expand the idea of human variation to the case of linguistic diversity and justice, showing that the logic of the HVM is present in other spheres of social life beyond disability. HUMVAR makes the case that minority languages are also disadvantaged by their social environment and vulnerable to discrimination-as-human-variation. It also examines the case of sign language through the lens of linguistic justice to find a novel answer to why changing individual impairments is problematic from a moral point of view. HUMVAR's answer is that society’s insistence on changing individual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development of decontaminator / bed pan washer'.

assistant: **Concept**

When a person is confined to one's bed there is a need to have a bed pan. After use it must be washed and disinfected. At hospitals, nursing homes and other institutions in many of the EC countries this is done mechanically through some kind of a washing and disinfecting machine. ln the US and some other countries the normal way is to use a non recurrent bed pan. Globally, the most common way is that this is done manually by some of the staff at the hospital drain the urine/evacuation, wash and disinfect the bed pan. At hospital, nursing homes and similar institutions there are a great need to cut costs decrease hazards of transferring bacteria from the urine/evacuation and improve the working conditions for the staff` who must do this job. There is also a need to try to have a competitive replacer for the non recurrent bed pan that is frequently used in the US. and thereby reduce negative environmental impact. The overall objective is to develop a fast low cost bed pan washer which has a programme cycle time of 3,5 minutes a reduction with 50 70 %. There will also be substantial reductions in energy consumption The core group is developing the fast, low cost bed pan washer but is impeded by technical problems from accomplishing this developing project. These main problems to solve in this RTD project are: - a method to fill in steam from a steam generator fast without creating overpressure - a device that reduces the rotation velocity of the nozzles without changing the water pressure. - a method for balancing/optimising the parameters in a bed pan washer an electronic steering system The approach to meet the objectives is to commission the performer group to solve the problems through RTD in steam techniques, microbiology, chemistry, stress/strain, simulations, engine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Novel Framework for Contactless diagnosis and forecasting of Cardiovascular Diseases' (ContactlessFramework).

assistant: **Concept**

In ancient times, doctors have followed unorganized practices to diagnose cardiac arrest conditions of healthcare patients.  The followed medical procedures were not very organized and accurate even though cardiac patients were diagnosed using devices, such as a stethoscope. However, the latest advancements in the technologies such as contactless remote patient monitoring, AIoMT (Artificial Intelligence of Medical Things), advanced big data and cloud-based analytics and alerts have created a paradigm shift in healthcare and provided 24 x 7 connectivity. The study proposed a VCardiac (Contactless Cardiac Classification and Risk Prediction) Framework to diagnose and identify early stages of heart diseases and forecast their cardiac conditions in advance using the human voice. In this study, a customized dataset termed ""Cardiac-2000"" with 2000 human voice samples will be designed to classify acoustic heartbeat events such as normal, murmur, extra systole, artifact, and other unlabeled heartbeat acoustic events. The average duration of the recorded heartbeat acoustic events would be 10 to 12 seconds. The primary reason for designing a customized dataset ""cardiac-2000"" is to balance the total number of samples into categories such as normal and abnormal heartbeat acoustic events. For performance evaluations of the proposed VCardiac Framework, the collected heartbeat acoustic samples will be classified using LSTM-CNN, RNN, LSTM, Bi-LSTM, CNN, K-means Clustering, and SVM methodologies. Furthermore, the proposed VCardiac Framework will also assist in classifying Age and Gender-wise risks using methodologies such as Kaplan-Meier and Cox-regression survival analysis. These methodologies will also assist in identifying the probability risk and the 10-year risk score prediction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Microbiology of Dehalococcoides-like Chloroflexi' (MICROFLEX), addressing dissemination and exploitation.

assistant: **Impact**

I propose to initiate research on a specific group of bacteria, here denominated as the “Dehalococcoides-like Chloroflexi”. This group of bacteria is formed by several cultivated strains of the genus Dehalococcoides and many sequences of uncultivated organisms mostly from marine sediment or subsurface locations. All together form one subphylum of the Chloroflexi. Bacteria of the Dehalococcoides-like Chloroflexi are of particular importance for two independent reasons: first, the subphylum contains all bacteria known to transform under anaerobic conditions toxic and persistent halogenated compounds such as chlorinated dioxins, benzenes, biphenyls, vinyl chloride or brominated biphenylethers; secondly, massive amounts of Dehalococcoides-like Chloroflexi have recently been detected in marine organic-rich deep sediments dominating the populations with up to 80% of the total cell counts. However, many aspects of the physiology of Dehalococcoides species are unclear and almost nothing is known about Chloroflexi in deep sediments. I have worked for many years on the microbiology, biochemistry and genomics of Dehalococcoides species. With the proposed group I plan to focus on the physiological links between Chloroflexi in contaminated aquifers and those in marine sediments. Initially, cultures of marine sediment-Chloroflexi will be established in our lab and compared with pure Dehalococcoides strains. Objectives of our research towards marine Chloroflexi will be the description of the physiology, of the biochemistry of energy conservation and of key genes encoded in the genomes. It is anticipated that the research leads to a substantiated hypothesis on the mode of energy fixation in marine deep-sediments and an initial description of the role of Dehalococcoides-like Chloroflexi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Regulation of Articular Cartilage Zonal Emergence:  Harnessing Developmental Pathways to Enhance Regeneration' (ReZone), addressing dissemination and exploitation.

assistant: **Impact**

Articular cartilage (AC) has a complex zonal structure and composition, providing it with its essential functional properties. However, when cartilage is damaged, the zonal complexity does not regenerate, leaving an inferior tissue which is prone to degeneration. As a result, cartilage injury commonly leads to pain and the eventual need for joint replacement. Progress towards true regeneration of AC requires an advance in understanding of how zonal complexity (and corresponding function) emerge over development. The most promising clue to understanding zonal emergence is that mechanical forces are known to be important for normal AC development.ReZone will reveal the mechanisms underlying zonal emergence through a novel goat model in which a common veterinary procedure is repurposed to create a radically altered mechanical environment in the developing joint. By comparing gene activity between normal and altered states of zonal emergence, I will identify pathways likely to be involved in zonal emergence. I will leverage my expertise in cartilage explant culture and mechanostimulation bioreactors to develop a novel in vitro explant model, and use this model to validate candidate pathways. Finally, I will demonstrate the therapeutic potential of molecular regulators of zonal emergence using gene-activated biomaterials to regenerate zonal emergence in an in vivo, large-animal model of cartilage repair.ReZone will provide a step-change in our understanding of how zonal AC develops postnatally, including the role of mechanical loading. The project’s ambitious aim is to bring about enhanced regeneration of AC through activation of the developmental processes which form functional cartilage in early life. Revealing key mechanisms underlying zonal emergence in immature AC will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mucins in the pathophysiology of inflammatory diseases of the bronchial and gastrointestinal epithelia' under Fourth Framework.

assistant: **Concept**

Objectives:The overall and long term scientific aims of this project are to understand the. The objective of this concerted action is to facilitate communication between g.Brief description:Although it has been known for a long time that the glycoproteins (mucins) attaL Much of the recent progress in understanding the biochemistry of mucins and theL This coordination of efforts will accelerate the progress in understanding the L Keywords:Inflammation, mucosa, mucin, chronic bronchitis, asthma, colitis, glycosylation.