RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mapping and Manipulating Interfacial Charge Transfer in Polymer Nanostructures for Photovoltaic Applications' (POLYMAP), addressing dissemination and exploitation.

assistant: **Impact**

The goal of the proposal is to develop unique capability and understanding of electroactive materials and their composites, for photovoltaic applications, through the use of emerging nanoscale electrochemical imaging techniques. By combining the strong background and experience of the Fellow (Josh Byers) in materials science, with the impressive facilities, equipment, infrastructure and expertise at the Host Institution, exciting new directions in hybrid photovoltaic materials will developed and explored. Nanostructured organic and inorganic materials are attractive for potential low cost photoelectrochemical energy generation for large scale exploitation. However, these materials are characterized by nanoscale features (typically tens of nm’s), and it has only now become possible to study their electrochemical response on a similar length scale using scanning electrochemical cell microscopy (SECCM), recently invented  by the Host Institution. The Fellow will join the Host group to expand the current capabilities to include high resolution photoelectrochemical imaging to study in detail the local (photo)electrochemical processes that occur at the interfaces of electrode materials for next generation photovoltaic devices (eg. dye sensitized solar cells), elucidating the impact of nanoscale morphology and structure on activity. Exploiting the nanoscale dimensions of the SECCM system, new methods for fabricating conjugated polymer nanostructures and composites will also be investigated to develop novel electrode materials. Through a combinatorial approach made possible by SECCM, these materials will be studied in-situ following their fabrication. The results of the project will provide a new view of photovoltaic devices at the nanoscale, ultimately allowing the rational de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Proof of Concept for a Platform for the Fast and General Elucidation of the Interaction Between Proteins and RNA', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to establish proof-of-concept of the utility of a new platform for fast and general elucidation of the interaction between proteins and RNA. The development of analytical methods for identification of RNA-binding proteins (RPBs) and their corresponding RNA motifs, will permit and accelerate: i) a deeper understanding of the roles of gene regulation and protein expression; ii) development of personalised medicines via regulation of protein expression; and iii) rapid identification of proteomes involved in specific diseases. In doing so, this project will have outputs which have significant market opportunities and societal benefits, including, but not limited to, stimulating job creation in the pharmabiotech and diagnostics sectors and reducing costs for national and EU healthcare budgets.


**Keywords:** RNA, proteomics, mass spectrometry, Fluorine chemistry, RNA-binding proteins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced affinity tools and technologies for high throughput studies of the human proteome' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

High specificity affinity reagents (‘binders’) are essential probes for proteome research, enabling the detection and localisation of multiple proteins in tissues and fluids in health and disease, through the application of binder-based technologies (affinity proteomics). This proposal links the high throughput production of quality-controlled, recombinant binding molecules of different types (antibody fragments, engineered scaffolds, aptamers) with advanced applications (capture microarrays, multidimensional fluorescence imaging, single molecule detection, intracellular knockdown) in the analysis of human proteome targets. The partners are five established SMEs and five leading academic groups, each with a reputation for innovation, engaged in binder production and characterisation or protein detection technologies. The project will aim to resolve bottlenecks in high throughput binder production and application technologies, including cost, throughput, automation and quality. The linkage of production, quality control and applications will be exemplified by targeting kinases and other proteins involved in the TGF-beta and MAP kinase signal transduction pathways, implicated in many diseases and where the availability of high quality binding reagents is particularly needed and drug development is actively evolving. As well as potential products, it will provide the SMEs with opportunities to exemplify and improve their technologies for future exploitation in proteomics, diagnostics and therapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Autonomous Vehicles to Evolve to a New Urban Experience' in the context of a Horizon 2020 call.

assistant: **Objectives**

AVENUE aims to design and carry out full scale demonstrations of urban transport automation by deploying, for the first time worldwide, fleets of autonomous mini-buses in low to medium demand areas of 4 European demonstrator cities: Geneva, Lyon, Copenhagen and Luxembourg, and 3 replicator cities. AVENUE revisits the offered public transportation services, starting from the original problem, which is to allow passengers to move from one place to another. It takes into account their special needs and time constrains, instead of trying to accommodate autonomous vehicles to the existing solutions of pre-scheduled bus itineraries. In this context, AVENUE introduces disruptive public transportation paradigms led by SMEs on the basis of door2door services and the nascent concept of the ‘Mobility Cloud’ aiming in setting up a new model of public transportation. This model enables safe, efficient, on-demand and emission free personalised public transportation, available anytime and anywhere, blending conventional public transport with novel service models such these of the sharing economy. The project partners will apply cutting edge technologies and I2V, V2I & V2V communications that will allow a twofold increase of the average vehicle speed and a tenfold increase in the range served by autonomous vehicles. A set of corresponding in- and out-of-vehicle services that substantially enhance road safety, the overall quality of the service and the value added to the passenger will be introduced, targeting also elderly people, people with disabilities and vulnerable users. AVENUE draws and builds upon the accumulated experience from its consortium of 16 partners from 7 European countries, and the operation of Navya’s 65 mini-buses in 22 cities from 13 countries in 4 continents that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a window system for the optimization of the energy gain in solar architecture' in the context of a Fourth Framework call.

assistant: **Objectives**

The progressive spread of solar architecture is increasing the demand for suitable windows. The aim of the research-project is the development of an adaptable window-system for various situations (orientation of the facade, climate zone, wind exposure), which makes possible an optimisation of the energy gain through the window as part of a solar facade. Heat insulation, protection against the sun and ventilation control should be specifically alterable by the integration of variable elements (like special roller blinds, daylighting elements, ventilation elements) into the window to meet the seasonally changing requirements. The new window-system contributes to the development of higher standards for windows moreover the cooperation of companies from several countries would lead to a faster market penetration of these standards.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Analytics for Biologics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Qualitative and quantitative analysis and purification of therapeutic protein species (TP-S) – coded by the same gene, thus chemically often very similar – is one of the most challenging problems in analytical chemistry today. This problem is of huge impact in the area of therapeutic proteins (TPs) – a rapidly growing market – causing a high demand in specialists in the field of TP manufacturing. This demand can currently not be met by single European universities. In an Europe-wide joint research and training network the graduate school A4B will offer a specific training program yielding the required specialists. A4B-PhD students will develop solutions for the most urgent problems in TP production and analysis. Production of TPs is associated with the generation of poorly effective or even harmful species. For an effective removal of these species, A4B-students will develop improved purification methods based on advanced affinity and displacement chromatography. For controlling effectiveness and design of experiments, fast and reliable qualitative and quantitative detection methods are required. The development of these analytical methods will focus on the chemical composition of TP-S including their glycans and other posttranslational modifications (PTMs). We will use high-end electrophoretic, liquid chromatographic, and mass spectrometry approaches in combination with bioinformatics. The developed methods will be tested and used for improving protein production processes and therapy control. All A4B students will receive a basic education in manufacturing and marketing of TPS. Through their research projects the students will develop in depth expertise in one of the areas covered by the consortium. This project will thus generate urgently needed new methods for an im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel senolytic drugs for the treatment of lung and kidney fibrosis' (SENFIB), addressing dissemination and exploitation.

assistant: **Impact**

SENFIB aims to deliver new drugs for the treatment of fibrotic diseases. Nearly one quarter of the global population will be over the age of 65 by 2050. Populations over 65 suffer from multiple degenerative diseases including tissue fibrosis, estimated to account for upwards of 45% of all-cause mortality. Animal models have demonstrated that senescent cells are causative in many fibrotic diseases including lung (i.e. idiopathic pulmonary fibrosis, IPF), and chronic kidney disease (CKD). Senescent cells have experienced damage or stress and have permanently exited the cell cycle, yet remain viable and long-lived, generating a persistent, sterile inflammation. Selective elimination of senescent cells in animal models of IPF, CKD, and aging demonstrated improved organ function and viability. Senolytics, molecules that induce preferential killing of senescent cells while leaving healthy cells intact, have emerged as a promising approach for tackling age-associated diseases; this was named one of the “10 Breakthrough Technologies” of 2020 by the MIT Technology Review. Thus far, few senolytics have been identified; their mode of action is often unknown, some present serious toxicities, and none has yet been demonstrated to have therapeutic activity in clinical trials.We propose to launch a drug discovery program based on a prioritized novel genetic target for senolysis, which we have already validated as senolytic using a tool compound in an in vivo model of IPF. We will deliver a lead series of molecules with IPR that meet all typical drug requirements plus in vivo Proof-of-Concept data in different mouse models of IPF and CKD. The ultimate goal of this project is to develop candidates for translation into clinical use to ameliorate fibrotic diseases via the selective elimin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Wake vortex characterization and control (C-WAKE)' to be submitted under Fifth Framework.

assistant: **Abstract**

The wake Vortex issue has aroused widespread interest, not only in the aviation community buy also in the general public. The main reason was a growing safety concern over potential hazards created by a Very Large Transport Aircraft" (VLTA), a novel airplane now on the drawing boards in Europe and the US and likely to enter airline service within the next decade. While the origin of wake turbulence is generally recognized, its physical characteristics in space and time continues to be insufficiently understood. As a result of the insufficient knowledge in wake characterization, its logical follow-on step is also lacking, that of wake control. Industry and authorities alike are pressing hard for progress to accelerate in this field, the industry to maintain competitiveness and growth, the authorities to assure high standards of safety. This C-Wake project is designed to address one of the most urgent topics in the field of Wake Vortices, that of Wake Vortex Characterization and Control."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Circuit and synaptic plasticity mechanisms of approach and avoidance social behavior.'.

assistant: **Concept**

Social behavior is defined as any modality of communication and interaction between two or more conspecifics. These behaviors, which include affiliative and antagonistic interactions, are exhibited by all sexually reproducing species, they are characterized by high-level complexity of communication through multiple sensory modalities and they are essential for survival. Humans and other animals living in groups continuously experience situations in which they need to select appropriate behavioral responses upon exposure to conspecifics. At the very basis of this social behavior, an individual needs to decide for example whether to approach (positive or appetitive) or avoid (negative or aversive) other individuals. Here, using mice, we will investigate the brain circuits and synaptic mechanisms involved in conspecific approach and avoidance behavior. The Nucleus Accumbens (NAc) is a key region of the mesocorticolimbic circuits for evaluating appetitive and aversive information. Recent studies have revealed the importance of NAc in social behavior, but which neurons within this structure are relevant and how they contribute to conspecific interaction is largely unknown. We hypothesize that different populations of neurons within the NAc orchestrate and integrate different types of socially relevant information to initiate the appropriate behavioral response. Using in vivo and ex vivo recordings and circuit-specific optogenetic manipulations in specific social interaction conditions, we will investigate how the NAc integrates information about conspecifics and how it incorporates learned associations to initiate conspecific approach or avoidance.  This study will thus identify and functionally characterize the circuit and synaptic mechanisms controlling socially appetitive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Gases in Water'.

assistant: **Innovation**

Is there “hidden” structure in normal liquid water? Do nanoscopic structural heterogeneities in ambient water exist and affect solution chemistry? In this project we will focus on structural fluctuations in simulations of liquid water as observed through the enhancement of the isothermal compressibility. From both experiment and theory a two-state picture of water is emerging with fluctuations between high- (HDL) and low-density (LDL) local structures. The structure of these is unknown. Moreover, present simulation models require a pressure shift of one thousand atmospheres to reproduce the experimental compressibility maximum at ambient pressure. We propose to develop a unique description of the liquid that extends to take into account that the water molecule exists in two forms, ortho and para, with different rotational properties. We will use Argon dissolved in water as discrete probe of the LDL local environments in high-resolution EXAFS measurements to discern their structure in combination. Finally, in a two-state picture with LDL structures providing “pockets of stability” for dissolved oxygen, the question arises how fish entice the oxygen to leave the water and enter the gills. We will carry out a combined experimental X-ray spectroscopic and theoretical modeling study of water in polyelectrolyte and polysaccharide models of the mucous layer found outside lamella of fish gills and specifically determine how water structure there differs from the bulk. Has Nature through evolution found a way to restructure the water to enhance exchange of gases?


**Keywords:** Liquid water, fluctuations, ortho and para water, X-ray spectroscopy, clathrates, fish gills, oxygen dissolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The Role of Non-coding RNA in Protein Networks and Neurodegenerative Diseases'.

assistant: **Concept**

A major portion of the eukaryotic genome is occupied by DNA sequences whose transcripts do not code for proteins. This part of the genome is transcribed in a developmentally regulated manner and in response to external stimuli to produce large numbers of long non-coding RNAs (lncRNAs). From the beginning of transcription through splicing and translation, RNA molecules are associated with numerous RNA binding proteins that regulate their processing, stability, transport and translation. Both coding and non-coding RNAs and their associated binding proteins are involved in numerous cellular pathways. These pathways, which include RNA processing and the regulation of transcription and translation, are critical determinants of neuronal differentiation and plasticity. Alterations in these pathways have been identified to contribute to a wide variety of neurodegenerative diseases. Mutations in two RNA binding proteins involved in RNA splicing, the Tar DNA binding protein of 43kd (TDP-43) and Fused in Sarcoma (FUS), cause amyloid aggregation and are associated with Amyotrophic Lateral Sclerosis (ALS). My main interest is to understand the role played by RNA molecules in protein networks. Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes. In this project, I propose to study associations of lncRNAs with proteins involved in i) transcriptional regulation and epigenetics (such as polymerases, transcription factors and chromatin-modifiers) and ii) neurodegenerative diseases (such as Parkinson’s -synuclein, Alzheimer’s disease amyloid protein APP, TDP-43 and FUS).  In particular, I will investigate if RNA molecules are involved in regulatory mechanisms that control protein production and prevent formation of toxic aggrega