RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Microbes in Allergy and Autoimmunity Related to the Skin' (MAARS) targeting Seventh Framework.

assistant: **Abstract**

Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know very little how microbe-host interaction triggers and regulate inflammatory cascade leading to allergic or autoimmune reaction. We propose that environmental and genetic factors, characteristic to particular disease, initiate a cascade of inflammatory events through the modulation of anti-microbial defence. The dysregulation of innate as well as adaptive immune responses leads to inappropriate responses to physical, microbial or allergen challenge, finally manifesting in the clinical symptoms of AD or PSO. We propose to use high-throughput whole microbiome and transcriptomics analysis with bioinformatics and systems biology to unravel the pathways during the host-pathogen interactions which may trigger an allergic or autoimmune reaction. We will identify key microbes and molecular targets to develop novel intervention strategies to decrease and prevent the burden of allergy and autoimmunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Crisis-Resilient Price Discovery in Decarbonized Power Systems' (CRISP) targeting Horizon Europe.

assistant: **Abstract**

Can we turn the Energy Crisis into an opportunity that advances the clean energy transition? Yes, we can, and we pave the path leading to just and equitable decarbonization. Debates that followed extreme events in Europe and the US pointed to a “wind of change” for the power market design and the price discovery process. Operators are put in the corner, inheriting market schedules that they more and more amend using their judgement, whereas they are also accountable for their out-of-market decisions. The process is inherently sub-optimal and costly! Extreme events may turn annual market revenues into daily energy costs!I will explore innovative ideas in Generalized Linear Programming and adaptive robust optimization with data-driven uncertainty sets, to support network and reliability related operator decisions, and novel machine learning developments to remove computational barriers while maintaining interpretability. Tackling major obstacles that derive from non-convexities, externalities, and uncertainty (to date open problems), leveraging demand adaptability, and combining optimization with economic theory, I will break new ground by (i) defining efficient, adaptive, and robust prices that minimize the gap between market outcomes and operator decisions, and (ii) designing innovative protection mechanisms that dynamically delineate the (blurred) boundaries between systems and markets encoding crisis resilience and shielding from catastrophic financial impacts.CRISP will break the barriers that have restricted power markets to “half-markets” for more than 30 years tapping adaptable demand and set the foundations for efficient scheduling and correct investment signals in innovation, infrastructure, resource adequacy, and sustainability. The theoretical and computationa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Isolation and characterization of genes specifically involved in somatic hypermutation process by rna differential display' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The somatic hypermutation process is responsible for the evolution of high affinity antibodies. This phenomenon takes place in the germinal centers, specific structures that develop in the B cell follicles of secondary lymphoid tissues during T-dependent immune response. Germinal centres are formed by two compartments: the dark zone containing the centroblasts and the light zone containing the centrocytes. It appears that somatic hypermutation process takes places place in the dark zone but the molecular mechanisms at the basis of this phenomenon are still poorly understood and are subject of intense investigation. The aim of this project is to separate centroblast and centrocytes subpopulations, extract their RNA and by using m-RNA Differential Display technique isolate the genes involved in the somatic hypermutation process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'DISTRIBUTED CODING FOR VIDEO SERVICES'.

assistant: **Concept**

Over the past decade several video coding technologies have emerged to achieve great commercial success and it is widely expected that digital video systems will completely replace all existing traditional analogue based video systems during the next decade. DISCOVER will address the development of several advanced digital video coding technologies which are very likely to represent a breakthrough in new video coding application scenarios. Until now video coding research and standardization have been adopting a video coding paradigm where it is the task of the encoder to explore the source statistics, leading to a complexity balance where complex encoders interact with simpler decoders. This paradigm is strongly dominated and determined by applications such as broadcasting, video on demand, and video streaming. Distributed Video Coding adopts a completely different coding paradigm by giving the decoder the task to exploit 'partly or wholly' the source statistics to achieve efficient compression. This change of paradigm also moves the encoder-decoder complexity balance, allowing the provision of efficient compression solutions with simple encoders and complex decoders. This new coding paradigm, never considered by any video coding standard, is particularly adequate to emerging applications such as wireless video cameras and wireless low-power surveillance networks, disposable video cameras, certain medical applications, sensor networks, multi-view image acquisition, networked camcorders, etc., where low complexity encoders are a must because memory, computational power, and energy are scarce. The objective of DISCOVER is to explore and to propose new video coding schemes and tools in the area of Distributed Video Coding with a strong potential for new applications, targe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Infrared imaging and sensing: the single-photon frontier'.

assistant: **Objectives**

Infrared sensing technology has a central role to play in addressing 21st century global challenges in healthcare, security and environmental sensing.  Promising new applications hinge on the ability to detect individual quanta of light: single photons.  At infrared wavelengths this is a formidable task due to the low photon energy, and commercial-off-the-shelf technologies fall far short of the required performance.  IRIS will engineer revolutionary photon counting infrared imaging and sensing solutions, with unprecedented spectral range, efficiency, timing resolution and low noise.  Using state-of-the-art materials and nanofabrication techniques, novel superconducting detector technology will be scaled up from single pixels to large area photon counting arrays.  Efficient readout and optical coupling solutions will be developed and implemented.  IRIS will exploit space age cryogenic technology to create compact and mobile detector systems.   IRIS will deploy these systems for the first time in revolutionary infrared imaging and sensing applications: dosimetry for laser based cancer treatment, atmospheric remote sensing of greenhouse gases and real-time distributed fibre sensing for geothermal energy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New drugs for persistent tuberculosis: Exploitation of 3-D structure of novel targets, lead optimisation and functional in-vivo evaluation' (NEWTBDRUGS) targeting Sixth Framework.

assistant: **Abstract**

TB is one of the most deadly infectious disease in the world. The high rates of patient non-compliance lead to more than three million deaths per year, as well as, to the creation of chronic, infectious, drug-resistant TB strains, against which almost all existing antibiotics are ineffective or prohibitively toxic. A short course of chemotherapy (two months or less) would significantly increase patient compliance, substantially reduce the rate of emergence of antibiotic resistance, decrease side-effects of treatment, and materially decrease the costs of treatment.We have made four scientific breakthroughs which indicate that it is feasible to develop such a drug:1. As part of a research project supported by the EC, we have recently solved the 3-D structure of several persistence related drug targets of M. tuberculosis. We have obtained information on ligands which shall be directly submitted to lead optimization pipeline.2. Our work has shown that persistent M. tuberculosis is metabolically active, and thus should be susceptible to specific chemotherapy, albeit different from current antibiotics.3. New assays have been developed for screening drugs which kill persistent M.tuberculosis. These assays can distinguish between drugs such as isoniazid which have little action against persisters, and compounds which are known to have some anti-persister activity such as pyrazinamide.4. We have identified unique compounds which kill M.tuberculosis including Rifampicin resistant strains. In the current project, we plan to apply our integrated strategy to the drug development pipeline by structural analysis of novel targets, virtual and real screening based identification of leads, new organic synthetic chemistry and functional evaluation in mice.The outcome of this project is ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sky Like Coating Materials for Hypogeal and SkyScrapers Architectures' under Seventh Framework.

assistant: **Concept**

Building skyscrapers, Real Estate has to constantly deal with social, economical and political issues. Nowadays market calls for a less conflictual and more profitable development niche, until now especially limited by livability and psychological constrains coming from the absence of natural light: underground architecture, including earth-sheltered and earth-covered buildings.Hypogeal spaces can tackle congestion, lack of open public space and aging infrastructures, exponentially increasing urban design opportunities to populate the “volume” contained by an over exploited earth surface. Underground can limit visual impact (zeroing main concerns about skyscrapers)and promote efficient land use in a noise and vibration-free environment, reducing energy costs by heat loss and daily temperature fluctuations control.Until now the discomfort caused by sky and sun deprivation consents hypogeal architecture only where protection from harsh climate conditions and natural disasters count more than above mentioned discomfort.SkyCoat, with a great leap underground, recreates the experience of natural light, obtained by complementary presence of both direct sun and diffused sky lights.Disadvantages of hypogeal architecture, like limited or no natural light and negative psychological reactions, are blown away by the possibility of reproducing the sun and the sky many meters under the earth surface, therefore opening a new and unexplored territory for real estate investors, architecture designers and buildings end-users.SkyCoat technology will also be verified in light design, testing how housing, offices, retail, industry and transport, can benefit from indoor natural light reproduction. At the same time, SkyCoat will be tested as coating material for skyscrapers: a thin layer of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'AI:Liner - Data-driven sewer asset management: a path toward the resilient transformation of Europe's sewer infrastructure' under Horizon Europe.

assistant: **Concept**

AI:Liner will enhance the asset management life cycle of sewer networks by designing, developing and validating a suite of cutting-edge technological and digital solutions. The project delivers a modular and interoperable end-to-end asset management tool chain that optimizes planning, operations, maintenance, investment, and reduces costs and risks of unexpected failures. It leverages the momentum of European utilities' digitalization efforts, building on the increasing availability of CCTV inspection data, AI-based fault detection, and recent advances in in-situ monitoring techniques to support the climate-neutral and resilient transformation of Europe's sewer infrastructure. AI:Liner empowers utilities and municipalities to identify intervention needs, enabling strategic decisions on when and where to inspect and rehabilitate sewers with the most appropriate technology, ultimately promoting the adoption of repair and rehabilitation techniques over the traditional excavation required for renewal. AI:Liner promotes the acceptance, trustworthiness and accountability of data-driven solutions, fostering a culture of trust, transparency and responsible use of data among European utilities and municipalities. By bringing together an interdisciplinary consortium that leverages expertise in infrastructure management, digitalization, and social sciences and humanities, AI:Liner enhances the digital skills of the utility workforce and integrates AI ethical principles at the core of technology development, ensuring the sustainable, responsible, and unbiased use of AI. AI:Liner strives to accelerate the digital and green transitions of the water and infrastructure sector, aiding European utilities in delivering high-quality services, maintaining affordable costs, and preserving in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Decorated Paper in the Early-Modern Islamicate World: Aesthetics, Techniques and Meaning in Global Contexts' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Moving away from Eurocentric art historical to truly global and interdisciplinary approaches, this project aims at re-evaluating the early-modern history of the Islamicate arts of the book from a so-far not considered perspective: the border and background decoration of manuscripts. The manifold forms of paper decoration and their techniques have hitherto not been systematically analysed by historians of Islamic Art, who instead have focussed on manuscripts figurative illustrations. Labelling decorative devices as subordinate to text and images has proven limiting to a full comprehension of art and to the exploration of global artistic contacts between different cultures within the Islamicate world and between East Asia and the Middle East. Drawing upon previous research initiatives by the PI, this project will bring together scholars from humanities and natural sciences in an interdisciplinary approach to aesthetics, materials, techniques and meaning of decorated paper produced and used in early-modern China, Central Asia, Iran, India and the Ottoman Empire. Favouring objects in the historical centres over well-known materials from collections in the West, this research is designed to further collections in the Middle East and Asia and to bring their understudied artworks under broader scholarly attention through publications and an interactive database.   The project has the potential to significantly re-shape the existing construct of Art History by shifting the attention to high-standard yet systematically ignored artistic production of decorated papers; meticulously investigating local traditions through innovative combinations of material analyses, the study of written sources and hardly applied comparisons with contemporary paper-decoration practices; and focussi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Higgs boson physics in the Standard Model and Beyond the Standard Model' (HBPBSM-SPR) under Sixth Framework.

assistant: **Objectives**

Our research project deals with the application of Quantum Field Theory to the phenomenology of High Energy particle Physics; more concretely, of the Higgs boson physics. The Higgs boson is the last building block of the Standard Model that is still waiting for experimental confirmation, and one has reasons to believe that there may be physics Beyond the Standard Model. Even if a neutral Higgs boson is discovered, a crucial question will remain still open: It is the Higgs particle of the Standard Model or, contrary, there is an extended Higgs structure Beyond the Standard Model. It is our aim to investigate quantum corrections to process that will be relevant for the intensive phenomenological studies needed to investigate Higgs boson physics in the next generation of planned colliders, such as the Large Hadron Collider at CERN. We will address the understanding of the physical mechanism cause of the symmetry breaking, mechanism responsible to generate the masses of the fundamental particles and we shall investigate whether some physics beyond the Standard Model exist, and the means of disentangle it. One of our main interests is to study process involving neutral and charged Higgs bosons that could modify the conclusions about the existence of these particles. To develop this research project we plan to use both the radiative corrections method and the effective Lagrangians techniques. The applicant and the host institution's scientists will benefit each other from the experience of the other part. This collaboration should allow to participate actively integrated in working groups for studies of future high energy colliders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identification of TRAIL sensitivity/resistance mechanisms and searching for novel TRAIL-sensitizing agents in Glioblastoma Multiforme' (TRIGBM).

assistant: **Innovation**

The overall goal of this proposal is to explore the molecular basis of TRAIL-response in an aggressive brain cancer, Glioblastoma Multiforme (GBM), and identify new reagents that will augment the TRAIL response of GBMs. Tumor necrosis factor related apoptosis-inducing ligand (TRAIL), emerged as a prime candidate for cancer treatment due to its tumor-specificity, however its clinical success is likely limited by the innate or acquired resistance of some tumors to TRAIL.  Dr. Bagci-Onder will address whether aberrant expression or activity of apoptotic program components is associated with TRAIL-resistance in GBMs. Specifically, she will address the role of a pro-apoptotic factor, harakiri (HRK), that she found to be significantly repressed in the TRAIL-resistant subpopulation of a primary GBM cell line. The potential role of this hitherto unstudied protein in GBM cell TRAIL response will be uncovered using expression analysis and functional assays in a large panel of GBM lines with varying TRAIL responses. Since multiple components of TRAIL signaling might be misregulated in TRAIL-resistant cells, Dr. Bagci-Onder will generate dual bioluminescent reporter systems of HRK and other TRAIL-associated factors, such as TRAIL receptors DR4/DR5; TRAIL signaling inhibitor proteins Flip, XIAP and Bcl-2 to assess gene expression changes. It is becoming evident that TRAIL-based combinatorial therapies with additional agents that can augment the TRAIL-response of tumors are more efficacious than using TRAIL alone. Using the novel reporter systems, Dr. Bagci-Onder will screen for novel TRAIL-sensitizing agents to identify potential TRAIL-sensitizers among FDA-approved chemicals.  The function of these agents will be validated in mouse xenograft GBM models using neural stem cells as ve