RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An innovative web-service to securely issue, store and verify online academic credentials' (CORE), addressing dissemination and exploitation.

assistant: **Impact**

From banking to travel, almost everything today is done via digital information and the Internet. One notable exception isacademic diplomas, most of which are still paper based. Academic records generation, issue and exchange by educationproviders involves slow, costly and forgery-susceptible processes with very low control over the protection of the informationreleased. Digitary CORE is a web service that allows education providers to securely issue, certify and share digitalacademic records online eliminating the hassle associated with having to produce and manage original paper documents.This streamlined system enables higher education institutions (HEIs) to reduce administrative costs, protect academicbrands, increase administrative efficiency, eliminate credential fraud and improve service levels for students and graduates.CORE represents the implementation of the original Digitary workflow, that is already on the market and whosedemonstration has been proved in several education systems. Ten years after Digitary’s world-first implementation ofdigitally signed Degree Certificates at the University of Limerick, almost a million online records have been issued byinternational institutions via Digitary branded platform. After having released the cloud-implemented platform (end of 2015)and integrated their software with foreign service providers, Digitary now aim at promoting CORE to verify credentials fromany University in the world. Accomplished Phase 2 objectives - demonstration of the implemented technology and marketreplication – will pave the way to increase Digitary visibility and then attract customers’ attention. This, in turn, will be crucialfor further strategic activities fostering the industrial-scale commercialization of CORE and developing new services t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Fluid-Rock InteraCTION at hydrothermal conditions during the seismic cycle'.

assistant: **Concept**

With ca. 50.000 casualties per year and 330 billion USD of damage in this century, earthquakes are among the biggest geohazards on Earth. Earthquakes are natural, often human-induced, phenomena in which a vast amount of elastic strain energy stored in rocks is suddenly released. A large amount of research has been performed to investigate fault mechanisms during earthquakes whereas much less has been done to constrain the chemical-physical processes of fluid-rock interaction during the seismic cycle and how these processes enhance the healing of fault zones, the storage of elastic strain energy in the crust and the nucleation of new earthquakes.The project FRICTION, building on the exciting results from a previous ERC project aimed to understand earthquakes mechanics from rupture nucleation and propagation to arrest, aims at investigating the feedback between seismic faulting, fluid-rock interaction, and tectonic loading in the processes of healing of fault zones and nucleation of earthquakes in the continental crust. FRICTION is innovative since it tackles a scientific topic which was so far overlooked with a multiscale interdisciplinary approach combining: high-detailed field structural characterization of exhumed ancient seismogenic fault zones, unprecedented rock deformation and fluid-rock interaction experiments under realistic hydrothermal and seismic conditions, both coupled with microstructural-petrophysical and chemical characterization of natural and experimental fault rocks.This integrated approach will lead to building a wealth of novel datasets to quantify the strength, friction constitutive properties, and sliding behavior of faults at hydrothermal conditions in the continental crust. The research will be conducted at Università degli Studi di Padova, wher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Hatha Yoga Project: Mapping Indian and Transnational Traditions of Physical Yoga through Philology and Ethnography' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Hatha was the name given in medieval India to a method of yoga in which physical practices predominate. Its origins are unclear, but some of its techniques can be traced to the first millennium BCE and it gradually became central to several Indian religious traditions, including, by the second half of the second millennium CE, orthodox Hinduism. Hatha yoga is also the source of much of the modern yoga practised around the world today.The history of hatha yoga is thus crucial for an understanding of both Indian religion and modern yoga, but is yet to be the object of serious study. As a result key questions about yoga — such as who were hatha yoga’s first practitioners and why did they practise it, and which modern yoga practices predate colonialism and which are innovations — are yet to be answered satisfactorily. The Hatha Yoga Project seeks to redress this by identifying the origins of both hatha and modern yoga. Its methodology will be predominantly philological and ethnographic, and it will draw on resources that are fast disappearing: crumbling manuscripts of Sanskrit texts on yoga and traditional Indian ascetic yogis whose practices are starting to change under the influence of modern globalised yoga.The primary output of the project will be three monographs. The first will analyse hatha yoga and its practitioners in the period in which it was formalised, the 11th to 15th centuries CE. The second will document its subsequent proliferation and development, and identify what constituted yoga practice in India on the eve of colonialism. The third will focus on hatha yoga’s physical techniques in order to chart their history and identify continuities with and differences from the practices of modern globalised yoga. A secondary output will be critical editions and ann
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Role of the stroma-derived ‘alarmin’ IL-33 in anti-viral immunity' (STRAVIR), addressing dissemination and exploitation.

assistant: **Impact**

There is increasing awareness that the recently identified cytokine IL-33 is playing a key role in multiple types of infections and pathologies. It has been recently demonstrated that IL-33 is crucial for mounting an efficient immune response against viral infections as it strongly enhances T cell responses with lack of IL-33 leading to failure in virus control. IL-33 production by stromal cells in lymph nodes (LN) and spleen is crucial for efficient viral clearance, however, the precise cellular source and signals involved in secretion of this nuclear alarmin during viral infection are unknown. In addition, it is poorly understood how this cytokine controls antiviral CD8 T cell function. To determine the cellular source of IL-33 during viral infections, we will assess IL-33 production by the different types of stromal cells present in lymph nodes and spleen during acute viral infection. The Luther lab has the expertise and state-of-the-art facilities to perform in situ characterization and in vivo analysis of stromal cell subsets present in these organs, allowing for the identification of the IL-33 producing population. Using IL-33GFP/+ mice will facilitate the identification of the cellular source of IL-33 during viral infections. Moreover, using in vitro cultures we will study the signals regulating IL-33 release as well as its role in T cells function. All together, the work described aims to increase our understanding of the mechanisms underlying stromal IL-33 secretion and its effects on antiviral T cell responses and wishes to broaden our knowledge on the role of stroma cells regulating immune responses. Importantly, this work could have future implications for antiviral treatments, including the development of better strategies for antiviral treatments including
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Efficient NMR crystallography of nucleic acid systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The goal of this proposal is to develop efficient strategies for the nuclear magnetic resonance (NMR) crystallography of organic molecular solids, focussing on nucleic acids and their derivatives. These systems are natural targets for the developing field of crystallography via NMR since H-bonding and tautomerism are central to their biological activity. The structure and function of RNA and DNA depends strongly on associated metal ions and with water molecules, but the non-covalent and dynamic nature of these interactions creates severe problems for their characterisation in the solution state, while characterising the role of water and hydrogen bonding in the solid state via X-ray diffraction techniques is also difficult. As well as providing a variety of challenges for NMR, such as paramagnetic metal ions, these studies will provide direct information on local structure and dynamics in these key biological materials that is inaccessible to conventional crystallography.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ignite the Immersive Media Sector by Enabling New Narrative Visions' (TransMIXR), addressing dissemination and exploitation.

assistant: **Impact**

The future of media experiences is still to be written, and the maturity of eXtended Reality (XR) and Artificial Intelligence (AI) technologies provides a unique window of opportunity for the European Creative and Cultural Sector (CCS) to reimagine digital co-creation, interaction and engagement possibilities. TransMIXR, a consortium of eight representatives from the CCS and twelve leading industrial and academic partners, combines the necessary interdisciplinary skillsets and domain expertise to create a range of human-centric tools for remote content production and consumption via social virtual reality. The project’s TransMIXR platform will provide (i) a distributed XR Creation Environment that supports remote collaboration practices, and (ii) XR Media Experience Environment for the delivery and consumption of highly evocative and highly-social immersive media experiences. The ground-breaking AI techniques for the understanding and processing of complex media content will enable the reuse of heterogeneous assets across immersive content delivery platforms.Using the Living Labs methodology, TransMIXR will develop and evaluate four pilots that bring the vision of future media experiences to life in four CCS domains: (i) news media & broadcasting, (ii) performing arts, and (iii) cultural heritage. Additionally, the project will harness the creativity of the CCS and will forge interdisciplinary collaborations to demonstrate how immersive social experiences could be transferred to new application areas beyond the CCS. The results of the project will contribute to the Media and Audiovisual Action Plan from the European Commission, in particular boosting the adoption of XR technologies, opening new business models opportunities in new application areas and markets, and gain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Developing novel inhaled bioengineered Extracellular Vesicle RNA based advanced therapeutics, delivered by tailored aerosol delivery technology for the treatment of lung cancer' under Horizon Europe.

assistant: **Concept**

Lung cancer (LC) treatments have advanced in recent years with the advent of genetic profiling and immunotherapy. However, LC is a complex heterogeneous disease and survival rates remain poor. RNA (mRNA, microRNA, other non-coding RNAs and nucleic acid based modulators of same) and gene therapies (DNA or gene editing) for delivering nucleic acid-based therapeutics have curative potential for a host of indications previously untreatable. They have yet to enter the mainstream, due to safety concerns and difficulties delivering them efficiently to areas other than the liver, kidney and circulatory system. Aerosol delivery allows direct targeting of lung tissues but viscous mucus in the lung is a significant barrier to gene transfer to the target cells of the lungs. Even if the mucus layer can be penetrated, inefficient penetration through the cell membrane further impedes access of these vectors to the underlying target cells, thus preventing successful gene transfer. Delivery is a major barrier to successful pulmonary gene therapy for competing viral and non-viral gene transfer vectors and the vast promise of gene therapy has many challenges to overcome. OMNI's novel solution is pioneering the use of genetically modified MSC EVs with a proprietary surface engineering technology to further enhance delivery through the mucus barrier and into the targeted lung cells. This platform technology also combines efficient aerosol delivery of the EVs via AERO's proprietary state of the art vibrating mesh nebulizer technology. This unique solution solves the problems associated with lung targeted delivery of RNA based advanced therapies.


**Keywords:** gene therapy, ATMP, Lung Cancer,  inhaled bioengineered Extracellular Vesicle aerosol delivery GMP manufacturing for in vivo screeni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular Mechanisms of Cerebral Cortex Development' in the context of a Seventh Framework call.

assistant: **Objectives**

The cerebral cortex, the seat of our cognitive abilities, is composed of an intricate network of interconnected neurons. The cortical cytoarchitecture consists of distinct layers with different cellular composition and function. Due to an immense heterogeneity in the cortical neuron types it is currently not known how many classes and which subtypes of cortical neurons make up the distinct cortical microcircuits in different functional cortical areas. The precise mechanisms of how these neurons coalesce into defined laminae and form specific connections with their synaptic partners during development are not well understood either. In a pursuit to obtain in-depth insights into these fundamental questions, we assess corticogenesis at unprecedented single cell resolution using the unique genetic strategy called MADM (Mosaic Analysis with Double Markers). MADM technology offers an unparalleled approach to visualize and concomitantly manipulate sparse clones and small subsets of genetically defined neurons in mice. Within the scope of this project we will use multidisciplinary experimental approaches including but not restricted to mouse genetic techniques and MADM, high resolution 4D live-imaging, and gene expression profiling. It is our objective to establish a research program with the following major aims: 1) Determination of cortical neuron lineages by clonal analysis; 2) Dissection of the molecular mechanisms of cortical neuron migration and 3) Probing of genomic imprinting, an epigenetic phenomenon, in cortex development. Together, these research directions shall precipitate into significant conceptual progress regarding the fundamental cellular, molecular and epigenetic principles of cerebral cortex development. Ultimately, such advances may result in a deeper under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of new approach for supporting the application of the Open Innovation in SMEs through the Peer-to-Peer leering' under Horizon 2020.

assistant: **Concept**

Despite the fact that SMEs can strongly benefit from implementation of the Open Innovation (OI) in many dimensions, the opportunities for the application of the OI model in SMEs still remain unexploited due to the different factors (e.g. insufficient support of the policies/incentives, difficulties in accessing the existing funding schemes supporting innovations, lack of capacities/awareness/know-how etc.). With limited resources and by acting only in limed environments, the potentials for innovation-related information flows and collaboration opportunities for SMEs are commonly restricted in all terms. Recognising the importance of establishing the new cross-sector value chains and infrastructures as new business ecosystems, InnTense aims at first line to explore current tendencies and to develop a methodology which will offer comprehensive support to SMEs in overcoming the barriers for successful application of the OI and its implementation on the broader levels. InnTense Project is a Peer learning of innovation agencies action, bringing together three Project partner from three EU Member States (Germany, Italy and Croatia) with an aim of setting up the standardised methodology for the innovation support for SMEs. Based on the pervious experiences and faced challenges, InnTense Project partners will analyse, assess and document the current state, factors, drivers, hindrances and benefits for the application of the OI model in SMEs, aiming at reinforcement of the SMEs innovation capacities. In order to achieve the main project outcome – InnTense Design Option Paper, the Partnership will apply a sequence of tasks which will be constituting parts of the Twinning Advanced methodology, underpinning the InnTense Project. In this way InnTense aims to deliver SMEs support for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A Programming Platform for Reactive Data-intensive Applications' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Ubiquitous connectivity of digital and physical worlds enabled by the convergence of edge (IoT, mobile), in-network and cloud computing plus algorithmic advances in artificial intelligence (AI) promise breakthroughs in next-generation Distributed Data-driven Reactive Applications (DRAs), which promise to radically innovate the economy and induce society-scale impact on production, mobility, energy, health, etc. But, such next-generation DRAs are not only expensive and difficult to develop, deploy, and maintain; it is also extremely hard to reason about and to ensure their quality. The goal of this Proof of Concept proposal is to build a business strategy for the implementation and provisioning of enterprise-level programming and methodological support for DRAs. The comprehensive REScala package provides necessary programming tools to support the cost-effective and quality-ensuring implementation of next-generation DRAs across application domains (mobility, energy, health, environment, etc.), involving and combining intelligent user interfaces and computations running on distributed computing platforms with decentralised state. Summarizing, REScala holds great promise to be an important enabler of next-generation DRAs. We expect the innovation potential of this PoC project to be comparable to that unleashed by the invention of smartphone platforms, which unified a myriad of separated silo technologies that emerged on top of mobile communication technology. With REScala’s distributed and decentralised computing model, developers can plug-in their DRAs similar to installing new apps.