RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Financial services reflecting the underlying decision making process'.

assistant: **Innovation**

In the finance discipline a lot of work has been conducted on the pricing of securities and derivatives. These pricing studies have been very important for the financial industry and economy in general. Recently, finance scholars turned to the psychology discipline to better understand how market participants behave in financial markets.The project will analyze market participants' behaviour in financial markets by truly understanding the underlying decision-making process of market participants. Since this process is latent (not directly observable), it is hard to study. However, the recent developments in the marketing and psychological disciplines provide tools that enable to model these latent processes.The project will run experiments with private investors to model the underlying decision-making process, and combine this experimental data with 'hard' trading data of the same private investors. In addition, it is recognized that the underlying decision-making process of market participants may be different for different segments of market participants.That is, while previous research modelled the 'average' market participant (by running a model across the whole population), here it allows for heterogeneity in the underlying decision-making process and hence it will be able to explain and understand heterogeneous behaviour that will be observed in financial markets. This project takes a marketing-finance interface approach, in that it will use the model that describes the underlying decision-making process as an input for the marketing product development model.That is, the project will not only yield understanding in how market participants behave, based on the true driver of behaviour, the decision-making process of market participants, but also will yield a metho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Computational and experimental studies of zeolitic catalysis' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The overall aim of the work is to elucidate the molecular processes accompanying the activation and operation of the nickel zeolite Y catalyst in the cyclotrimerisation of acetylene. The project will employ a unique combination of experimental and computational methods. The synchrotron radiation techniques (both diffraction and EXAFS) will be complemented by neutron scattering studies in order to determine structures and structural changes in the catalyst. Studies at the atomic and molecular level will also be modelled by computational techniques (principally energy minimisation and molecular dynamics). Dynamical simulations will also be employed to model the diffusion of acetylene towards the Ni2+ cation in the supercage of the activated catalyst. In the final stage of the work, electronic structure methods based on density functional theory will be used to model the detailed mechanism of the cyclotrimerisation reaction. The outcome of the project will be a detailed understanding at the molecular level of the catalysis in this key system. Training content (objective, benefit and expected impact) The project will give an excellent training in the techniques of high resolution powder diffraction (both X-ray and neutron). EXAFS and both forcefield and electronic structure based computer modelling methodologies. The project will exploit these important contemporary techniques in the context of current catalytic research. Links with industry / industrial relevance (22) The Royal Institution catalysis research has close links with industry in the UK, Europe and worldwide. Catalysis is central to the modern chemical industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Measuring Eta_Earth: Characterization of Terrestrial Planetary Systems with Kepler, HARPS-N, and Gaia' (ETAEARTH) targeting Seventh Framework.

assistant: **Abstract**

We propose to carry out an FP7 collaborative project to provide the first ever quantitative answer to one fundamental age-old question of mankind: ‘How common are Earth analogs in our Galaxy?’. We will achieve our goal by combining the unprecedented photometric precision of NASA’s Kepler mission, the unrivalled precision of ground-based radial-velocities from the HARPS-N spectrograph, and ESA’s Gaia mission exquisitely accurate parallaxes.  Ours is a transnational collaboration between European countries and the US setup to optimize the synergy between space- and ground-based data whose scientific potential can only be fully exploited when analyzed together. We ask for manpower and resources to carry out a GTO program with HARPS-N@TNG (80 nights/yr for 5 years) to measure dynamical masses of terrestrial planet candidates identified by the Kepler mission. With the unique combination of Kepler and HARPS-N data we will learn for the first time about the physics of their interiors. Some of these planets will have characteristics (masses, radii) similar to Earth, and they might be orbiting within the habitable zone of stars much like our Sun. We will search for planets similar to Earth orbiting a carefully selected sample of nearby bright solar-type stars and red M dwarfs, providing suitable candidates for spectroscopic characterization of their atmospheres with next-generation space observatories. We will combine Kepler, HARPS-N, and Gaia data products of  stars in the Kepler field to underpin the occurrence rates of terrestrial planets (η) as a function of stellar properties with unprecedented accuracy. Our unique team expertise in observations and modelling of exoplanetary systems will allow us to fully exploit the potential for breakthrough science intrinsic to this cut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Standardisation and improvement of generic pre-analytical tools and procedures for in vitro diagnostics' (SPIDIA).

assistant: **Concept**

In vitro diagnostics have allowed a great deal of progress in medicine but are limited by two factors: (a) the lack of guidelines in collection, handling, stabilisation and storage of biosamples which limits the reproducibility of subsequent diagnoses, and (b) its scale is restrained to the cellular level. To address this first point, this IP, SPIDIA, built of clinicians, academics, tool and assay developers, aims to develop quality guidelines for molecular in vitro diagnostics and to standardize the pre-analytical workflow in related procedures. Regarding the second point, SPIDIA aims to develop modern pre-analytical tools for diagnostics improving the stabilisation, handling and study of free biomolecules within blood, plasma, serum, tissues and tumours. Recent discoveries have revealed that RNA, DNA or proteins, released from pathological sites, like tumour cells or Alzheimer’s disease (AD) brain lesions, into the blood or as a secondary blood based response to the disease can serve as biomarkers for early and reliable molecular diagnosis of such debilitating diseases. Further discoveries have shown that the cellular profiles of these molecules and structures in clinical samples can change during transport and storage thus making clinical assay results and pharmaceutical research unreliable or even impossible. It will therefore be a decisive prerequisite for future and current diagnostic assays to develop standards and new technologies, tools and devices that eliminate the human error in the pre-analytical steps of in vitro diagnostics. At this crucial moment in the development of molecular diagnostics, SPIDIA proposes an IP that reunites 7 private research companies (including 4 SMEs), 1 private research institute, 6 public research organisms, including universities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Secondment for the development of Research  Innovation  in Biomaterial Rapid Prototyping' to be submitted under Horizon 2020.

assistant: **Abstract**

Secondment for the development of Research & Innovation in Biomaterial Rapid Prototyping (SECOND.R.I.) exchange programme aims to establish and support inter-sectorial and international sharing of knowledge and enable new professional skills for researchers and managerial staff enhancing potential innovation of the S&T research in rapid prototyping and biomaterials for bone tissue engineering. In order to achieve these objectives SECOND.R.I exploits the complementary competences of an inter-sectorial Sino-European consortium. The project undertakes collaborative research and innovation activities on new biomaterials for rapid prototyping for application in bone tissue engineering. Using rapid prototyping (RP) technologies a tailor-made and functional scaffold based on natural polymer and calcium phosphate will be developed and tested in an industrial environment. Running parallel with this research programme, an innovation management work-package explores the best solutions to exploit the research results (e.g. through the analysis of different innovation systems) thanks to the involvement of two technology transfer centres and one SME. In particular international technology transfer and intellectual property protection, absorptive capacity and technology innovation networks, human resource management, and how the interplay of these factors influences technological innovation in Chinese and European enterprises, as well as the associated impacts on EU policies and enterprises in the biomaterials sector will be investigated. This unique initiative has its strength in the composition of its consortium which is global and multidisciplinary hence is expected to accelerate scientific and business progress in the strategic field of bone tissue engineering and to foster strong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Lab-on-a-chip microfluidic device based on plasmonic driven thermal  nanobiosensing for rapid detection of Salmonella in chicken meat.'.

assistant: **Concept**

NANOIMMUNOTECH (NIT) is a nanobiotechnology Company which is the sole exploiter of an exclusive ultrasensitive biosensor nanotechnology, called HEATSENS. Thanks to the innovation of using gold nanoprisms, it is able to detect analytes with a low level of detection (attomolar detection limit, one million times more sensitive than competitors), in a faster, cheaper and simpler way than current methodologies do. The aim of this Project is to implement HEATSENS technology in a specific biosensor product: HEATSENS_S, a biosensor able to detect Salmonella in chicken meat on the same working day both for positive and negative results, at an affordable price for customers (where current methodologies take not less than 19hrs). It means a huge impact for the poultry industry, in terms of time and money saved, and food safety.HEATSENS_S is already implemented on a lab prototype (TRL6), and its commercial, technical and financial viability was proved and reported on the SMEI-1 Feasibility study. Relevant final customers (who acknowledge to be willing to pay for the product and collaborated on the product specifications) and key stakeholders, are also involved in the Project. These contacts will be expand during SMEI-2 in order to set a solid commercialisation channel. HEATSENS_S will be market ready in 18 months’ time, right after the end of the Project. It will be the inflection point in NIT profit, turnover and human resources trends, leading its medium and long term business strategy and increasing NIT Company value up to 30 times, multiplying by 4 their sales from 2019. All in all, once that this first launch is on the market, NIT will easily enter different biosensor market niches by extending HEATSENS_S. The business model consists on a device in which consumables for the de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation and Metabolic Engineering of Saponins for use as bio-pesticides.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Insect pests and pathogens cause major losses in agriculture, and there is a critical need to develop novel and sustainable methods to reduce these losses. Plants produce a vast diversity of specialized chemicals that deter antagonist, but in spite of their potential for pest management they are still largely unexplored. We need to understand better how such defence compounds are synthesized by plants and what biotic and abiotic conditions trigger and regulate their production, in order to develop and use them sustainably. The objective of my REMES project is to uncover the genetic and molecular regulation of triterpenoid saponin biosynthesis, using the insect-resistant wild crucifer Barbarea vulgaris as a model system, and explore their use as bio-pesticides. I will 1) characterize transcriptional regulators of the saponin biosynthetic pathway; 2) explore how saponin biosynthesis responds to different functional types of insects and pathogens in B. vulgaris; and 3) manipulate the regulatory responses and production of saponins to assess their potential as sustainable bio-pesticides. In the project, I will take advantage of the experience and state-of-the-art facilities at the host in systems biology, molecular biology, biochemistry, bioinformatics, metabolomics and plant-insect interactions; in turn, I will contribute my own expertise in characterization of transcriptional regulation of specialized metabolism in plants. With the project I will consolidate my career in research whilst also developing important academic and transferrable skills for pursuing a future career in academia. Altogether, the project will improve our understanding of saponin biosynthesis and regulation, which will improve the industrial interest and means to develop crops with modified content o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structural characterization of the type III secretion translocon of Pseudomonas aeruginosa' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Bacterial pathogens have developed highly specialized processes to target hosts and establish infection. A recently described weapon, the type III secretion system, transfers toxins from the bacterial cytoplasm into the host cell through a pore formed on the host cell membrane upon cell-to-cell contact. In this project, we will use X-ray crystallography to study PopB and PopD, the two membrane proteins required for pore formation by the nosocomial pathogen Pseudomonas aeruginosa, both in their intrabacterial form and as the finalized ring-like pore.The structural study of membrane proteins has proven to be a challenging endeavor, mainly due to the difficulties presented by the production and purification of membrane proteins in high amounts. PopB and PopD, however, are expressed in the bacterial cytosol in soluble form, complexed to a chaperone, PcrH; in the host laboratory, such complexes can be expressed and purified in milligram quantities, an absolute requirement for successful crystallization experiments. In addition, the host laboratory has already produced preliminary crystals of the PopB:PcrH complex and has expertise at reconstitution of the PopB/PopD pore. Crystallization trials will be performed with TECAN robotics, available at the IBS, and all data will be collected at the ESRF synchrotron in Grenoble.Highly related type III secretion systems are employed by a variety of other pathogens, such as Yersinia pestis, the causative agent of bubonic plague, and Salmonella typhi, the agent of typhoid fever.Thus, the structural study of the type III secretion pore from P. aeruginosa will provide crucial information regarding the infectivity processes of other pathogens. Targeting a specific host:pathogen interaction which is crucial for bacterial infectivity, such a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Open Distributed Digital Content Verification for Hyper-connected Sociality' (SocialTruth) targeting Horizon 2020.

assistant: **Abstract**

The extreme growth and adoption of Social Media, in combination with their poor governance and the lack of quality control over the digital content being published and shared, has led information veracity to a continuous deterioration. Current approaches entrust content verification to a single centralised authority, lack resilience towards attempts to successfully “game” verification checks, and make content verification difficult to access and use.    In response, SocialTruth’s ambition is to create an open, democratic, pluralistic and distributed ecosystem that allows easy access to various verification services (both internal and third-party), ensuring scalability and establishing trust in a completely decentralized environment. The distinctive advantages are:  a) avoidance of vendor lock-in through access to configurable combinations of various content analytics and verification services (with support for text, image and video content) via standard Application Programming Interfaces;  b) distributed trust and reputation establishment powered by blockchain technology, ensuring immutability and auditability, revealing information cascades and empowering an information veracity observatory;  c) integration of lifelong learning approach for detection of new paradigms of fake news;  d) easy interaction through a Digital Companion that allows convenient everyday access of individual users to verification services from within their browsers.   SocialTruth will benefit:  a) Individual users to verify the validity of Social Media content and prevent misinformation spread;  b) Media organisations, content authors and journalists to boost their investigative capabilities by enabling improved cross-checking of various multimedia information sources;  c) Search engines, Social
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Probing the role of mechanosensory pathways in regulating intestinal stem cell activity and gut homeostasis'.

assistant: **Innovation**

In adult organisms, gut barrier function is maintained by adapting the proliferation and turnover of resident intestinal stem cells (ISCs) to environmental cues. In recent years, an immense effort in the field has successfully identified many short and long-range signals involved in ISC-driven adaptive growth responses. However, it is becoming increasingly evident that biomechanical cues, such as shear stress, compressions, swellings, and tissue-scale tension, also play a key role in regulating SC activity in adult tissues. Hence, the adult gut is constantly exposed to mechanical stress and must adapt accordingly to the stretch and strain. Despite the undisputed impact that mechanical forces have on adult organ physiology, very little is known about the molecular signals involved. Using Drosophila as a model, we performed a genetic screen for ISC niche receptors coupling environmental cues with ISC-dependent adaptive growth and identified several receptors belonging to mechanotransduction pathways as indispensable for preserving gut barrier function. Mechanical forces can be either of tissue intrinsic origin, such as forces emanating from cell division and cell death, or of external origins, such as those originating from extracellular matrix remodeling, mechanical coupling to neighboring tissues, and food and fluid flow. Recent studies in developing embryos and during tissue morphogenesis show that cells can sense mechanical forces through mechanotransducer proteins, and are used as cues to regulate gene expression patterns, cell fate specifications, cell packing, and proliferation. An insight into mechanosensation in regulating ISC niche homeostasis in mature organs is still lacking and given my scientific background in biophysics and mechanobiology, this study aims t