RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Reversing T cell dysfunction in cancer by multimodal genetic screening' under Horizon Europe.

assistant: **Concept**

T cell dysfunction is a key problem in cancer, enabling not only tumorigenesis but also causing resistance to immunotherapy. Induction of immune checkpoints is a hallmark of T cell dysfunction, but clinical blockade by PD-1 and CTLA-4 antibodies solves this problem for few patients only. Dysfunction is driven also by additional mechanisms, including chronic stimulation and metabolic insufficiency. A better mechanistic understanding will be imperative for improving immunotherapy.  My laboratory recently launched ReverT, a genome-wide CRISPR-Cas9 screening program to identify genes, ablation of which reverses dysfunction in primary T cells. To de-risk this application, we have already successfully completed three such screens in vitro, for chronic antigen stimulation, metabolic stress and PD-1 induction, validating and characterizing several dysfunction genes not previously reported. Furthermore, an independent follow-up re-screen with a Dysfunction Reversion Candidate (DRC) mini-library containing the top 100 hits of each of these screens validated >100 genes that reversed T cell dysfunction in vitro.  Here, we will carry out the most challenging and important step: to systematically validate and mechanistically characterize this collection of T cell dysfunction genes in vivo. This will be done in a pooled and multimodal fashion, analyzing multiple dysfunction phenotypes in parallel, specifically immune checkpoints, exhaustion, metabolism, recruitment and proliferation. Our proof-of-concept results indicate that the DRC library contains nodal factors, operating in several seemingly different dysfunction settings, which may thus in fact be linked. We will use a collection of adoptive cell transfer mouse and human tumor models for validation and mechanistic characterizatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Laser Filamentation for Probing and Controlling Atmospheric Processes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The prevention of damaging weather phenomena like floods, hail and lightning strikes has been a dream for centuries. We propose a highly innovative approach relying on laser filaments for both triggering and guiding lightning and produce water condensation in the atmosphere. Filaments are self-sustained light strings of typ. 100 um diameter and hundreds of meters length in air, bear very high intensities and are electrically conductive through molecular ionization.The filamentation process in air was considered until recently as resulting from the dynamic balance between the optical Kerr effect and defocusing by the self-generated plasma. Our unexpected discovery, last year, that filaments are governed by negative higher-order Kerr effect (HOKE), opened both basic physical questions about the stabilization mechanism and new opportunities to optimize the envisioned applications to lightning triggering and cloud condensation.We propose first to study in the laboratory the physical origin of the alternated signs of HOKE in gases, which are suspected to stem from populated bound states. Coherently controlling these bound states in rare gases and air will allow us to tailor the HOKE inversion, and consequently to control the filament process itself. Optimal pulse shapes will then be sought by adaptive (closed loop) techniques to maximize the plasma density and lifetime in filaments for lightning control applications. Similar coherent control approaches will be performed for optimizing the complex photochemistry that leads to water vapor condensation in the atmosphere.We will then apply the optimal pulse shapes to real scale field experiments. To this end we intend to use the mobile TW laser from the Teramobile consortium, which we are part of, in order to perform two extensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Survival of Damaged Medieval Polychromed Heritage in the Nordics' (POLYCHROME).

assistant: **Concept**

POLYCHROME will study the shifting fortunes of richly painted and gilded (polychromed) Christian images that have survived in the Nordic countries since the Reformation. How have wooden sculptures, panel paintings, shrines, and winged altarpieces transformed from potent objects of devotion to cultural heritage? To what extent is this category of cultural heritage at risk? Values attached to Catholic devotional objects have fluctuated dramatically since Gustav I of Sweden and Christian III of Denmark-Norway declared a break with the church in Rome (1527 and 1537, respectively). However, documentary sources shed little light on changes in status, volatility, and repairs.POLYCHROME will take an ambitious leap that scholars concerned with polychromy in Denmark, Norway and Sweden have been reluctant to make: to determine the extent to which losses of noses, eyes and limbs are tied to iconoclastic acts. To date, historians and most conservators have attributed damage to accidents or unspecific vandalism, but not to targeted violence. This is due in part to a lack of archival evidence, but also because secondary paints often mask critical information on surfaces and in internal structures. POLYCHROME will harness technologies from the natural sciences to create, from the ground up, the first analytical overview of c. 150 polychromed objects that are (or potentially were) partially mutilated. The material data will offer essential foundations for determining whether damages and losses can be linked to violence, accidents or inherent weakness. The data will guide the mapping of restorations and repairs, and will establish foundations for multidisciplinary studies and cross-cultural debates about heritage values and the future care of religious heritage in the Nordics. The outcom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Angiotensin II converting enzyme inhibitors (ACE-I) in young patients with IgA nephropathy: effects against deterioration of renal function' under Fourth Framework.

assistant: **Concept**

- To determine the therapeutic potential on the progression to renal failure of Angiotensin Converting Enzyme Inhibitors (ACE-I) in children and young adults with primary IgA Nephropathy.  - To detect the effect of this treatment on proteinuria and circulating IgA containing macromolecules- To identify genetic, immunologic or histologic factors able to forecast responders and non responders .IgA Nephropathy (IgAN) is one of the most common glomerulonephritis, accounting in Europe for 10-30% of all glomerular diseases that underwent renal biopsy. According to the 1994 EDTA Registry, 25% of patients with evolutive IgAN start renal replacement therapy by their twenties and other 35% by the age of 44 years. Considering the general progression rate of IgAN (25% of the cases need dialysis in 20 years),a successful treatment during the first two decades of life will provide the greatest potential benefits. Clinical indicators of poor prognosis are proteinuria and hypertension. Angiotensin II (Ang II) plays an important role in systemic and glomerular hypertension, glomerular permselectivity and proteinuria as well as in modulating mesangial and tubular cell function. Many in vitro and clinical data indicate that ACE-I are the most promising agents for treatment of IgAN.Based on these observations, this European multicenter study will investigate the potential benefits of ACE-I in young patients with IgAN presenting significant proteinuria. Section 1: will deal with the clinical trial enrolling patients from 29 major European Centers of Pediatric Nephrology. Patients aged 20 years at time of renal biopsy (done<5 years before) showing prevalent IgA mesangial deposits, at high risk of progression (proteinuria 21 g/1.73m2/day) will be enrolled in a cohort large enough to achieve r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Design and construction of programmed protocells for intercellular networks and biomimetic communications' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Artificial cellular counterparts (protocells) can be fabricated to produce explicit biomimetic outcomes such as RNA-mediated replication, gene expression, metabolism, etc. These synthetic mimics with cell-like traits, aim to answer fundamental questions regarding origin of cellularity from non-living components. However, minimal levels of structural/organisational complexity exhibited in current protocell designs, limits their application potential. The aim of this proposal is to use bottom-up approaches to precisely design and construct complex protocells through membrane coupled appendages and produce interactive protocellular communities which will recognize, sort and processes chemical signals through collective behaviour.  The self-assembled protocellular colonies will be sequestered with complex enzymatic reaction networks which operate spontaneously and synergistically reminiscent to living cells. Several important functions such as selective formation of protocellular consortia, mimicking important biological functions such as IDH-kinase/phosphatase (AceK) circuitry from the Krebs cycle, redox-homeostasis, self-protection from chemical degradation will increase the complexity of the protocellular constructs producing the first example of functional proto-colonies. The expertise of the applicant in the field of organic synthesis, supramolecular chemistry and out-of-equilibrium self-assembly will be employed by the multidisciplinary and evolving field of protocells pioneered by the hosting group of Professor Stephen Mann FRS at the University of Bristol. The combined research efforts of the applicant and the Mann group will result in the successful realization of programmable protocells resulting in active self-assembling protocellular constructs and build their a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'New European Schemes for Signature, Integrity, and Encryption'.

assistant: **Objectives**

The project will put forward a portfolio of strong cryptographic primitives that has been obtained after an open call and been evaluated using a transparent and open process. The project intends to contribute to the final phase of the AES (Advanced Encryption Standard) block cipher standardisation process (organised by NIST, US), but will also launch an independent open call for a broad set of primitives providing confidentiality, data integrity, and authentication. These primitives include block ciphers, stream ciphers, hash functions, MAC algorithms, digital signature schemes, and public-key encryption schemes. The project will develop an evaluation methodology (both for security and performance evaluation) and a software toolbox to support the evaluation. The project goal is to widely disseminate the project results and to build consensus based on these results by using the appropriate fora. A final objective is to maintain the strong position of European research while strengthening the position of European industry in cryptography.DESCRIPTION OF WORKIn a first phase, an open call for the submission of cryptographic primitives as well as for evaluation methodologies for these primitives will be published. This call will include a request for the submission of block ciphers (as for the AES call), and other cryptographic primitives including hash functions, additive stream ciphers, and digital signature algorithms. In addition, it will ask for evaluation methodologies for these primitives. In parallel, a software toolbox will be developed for generic and later on specific evaluations of primitives, taking into account the submitted testing methodologies. A first part of the security evaluation will consist of an analysis of the AES finalists, resulting in joint commen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced quantum information research' in the context of a Fourth Framework call.

assistant: **Objectives**

The primary aim of this project is to realise noiseless and ultra-low threshold optical components for improved optical information processing, transmission, display and storage, by exploiting the principles of quantum optics and electronics. The objectives can be broken down into two main categories:1) Compact and integrated/fibre noise-free optical amplifiers and optical taps, with performances beyond the usual shot noise limit.2) Light generators where the efficiency and noise will be optimised as far as allowed by the basic quantum limits. Special emphasis will be put on light emitting microcavity The concept underlying noise-free amplification, coupling and taping is optical parametric interaction, that allows to circumvent the classical 3 dB limit for the added noise. It will be implemented in miniature crystal resonators, wave guides and fibres, with a special emphasis on soliton pulses for the latter system. These devices can be utilised as light generators as well as amplifiers. Under such conditions they constitute sub-shot noise sources.Other controlled-noise sources will be obtained by cavity engineering of classical commercially available semiconductor lasers. Stripe and vertical cavity type lasers will be considered. Microcavities with various types of emissive materials, such as semiconductor quantum wells and dyes in polymers will be assessed. Thresholdless behaviour and high efficiency will be sought.The integrated/fibre devices for noiseless amplification and duplication aimed by this project constitute the building blocks of a noise-free optical bus. They will ultimately lead to the demonstration of a compact information-carrying channel that can be read out by several users without contamination by noise.The development of light emitters with an opti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulation of hpv 18 gene expression - a identification of tissue-specific transcription factors interacting with ap-1' to be submitted under Fourth Framework.

assistant: **Abstract**

HPV gene expression relies tightly on its enhancer which in turn restri its activity to keratinocytes. In these permissive cells, viral expression is modulated by their differentiation status. The mechanisms that direct this selective transcriptional control have not been elucidated. We propose thus to characterise the structure, function, and regulation of the HPV 18 enhancer, and to identify the cellular transcription factors participating to its cell-type specificity. As AP-1 plays a central role in the enhancer activity, we will first look at the relative distribution of its different Jun/Fos members in a normal differentiating epithelium and compare it to a virally infected tissue. We will also examine the binding of these Jun/Fos heterodimers to the HPV 18 AP-1 site. We will next identify the unknown transcription factors that synergistically interact with the Jun/Fos complex, and study their expression in the epithelium and other tissues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Maximising tidal energy generation through Blade Scaling &  Advanced Digital Engineering'.

assistant: **Innovation**

The MAXBlade project will specifically focus on delivering a 70% increase in rotor swept area of the technology by addressing design, reliability, condition monitoring, maintenance and control issues relating to tidal turbine blades.  All of these issues have to date been insufficiently addressed for tidal turbine blades and need to be holistically tackled to reach a site-averaged €30/MWh cost reduction in tidal stream energy, while maturing the technology to address barriers around investment attractiveness.  The project also anticipates significant challenges and expected legislative requirements around applying circular economy principles to tidal stream turbine blades in pursuit of a net zero generation sector. With a close interface between blade design and testing activities, the project addresses a comprehensive circular economy roadmap for tidal turbine blades, including advancing the potential of recyclable thermoplastic resins for use in the composite blades.The project also progresses initiatives to ensure that the European composite sectors become the international leader in tidal blade manufacture through knowledge transfer, practical engagement in the blade production design and identifying and addressing barriers to increasing European supplier capacity. The project will consist of a 2-year design and development phase, an 18-month build, followed by a 2-year performance verification through the build of a tidal array of at least two units (c. 5MW), ensuring that 8 blades (4 rotors) are tested providing cumulatively 120,000  hours of rotor performance data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Computational modeling and physiological studies of neural form and function in the aging brain' (ANAMNISIS).

assistant: **Innovation**

Aging-induced memory deficiencies are caused by dysfunctions of various brain regions, including the hippocampus and the prefrontal cortex. Currently not much is known about the anatomical and biophysical properties or the underlying molecular mechanisms that enable these regions to contribute to memory formation or the effects of aging on neural learning and storage capacity. In this project, we propose to combine electrophysiological and modeling approaches to address issues pertaining to aging induced changes in cellular properties and how these influence the information processing capacity of hippocampal and neocortical cells. Towards this target, we will first perform electrophysiological experiments to characterize the intrinsic properties of young and aged pyramidal neurons and then use the accumulated as well as existing data to build realistic compartmental models of these cells. Models will incorporate both anatomical and biophysical information and will be used in simulation experiments to study the effects of aging on the excitability and integrative properties of hippocampal and neocortical neurons.  We are especially interested in (a) investigating the ability of aged neurons to support nonlinear dendritic integration and process incoming signals like multi-layer neural networks and (b) identifying key mechanisms that influence dendritic integration properties as they may serve as a basis for new medical interventions that can alleviate memory loss in the elderly.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Economics of the Intelligent Transportation Services' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Technological advancements have enabled new flexible and demand-responsive transportation services, whose significance on both urban and rural transportation systems have been increased rapidly due to the successful transport network companies such as Uber and Lyft and due to innovative public transportation operators developing automated demand-responsive services with public-private-partnerships. At the same time, there has been also increasing interest in these services in several academic disciplines like operations research, transportation economics and computer science. Recently, research has focused on modelling these services and related pricing policies, and on developing algorithms for optimal vehicle routing and demand management.During the fellowship period, the object is to achieve deeper understanding on the economics of the intelligent transportation services by extending the economic models of the automated demand responsive transportation   and by adopting recently developed simulation models of the Max-Planck Institute, which utilize trip origin-destination data collected in Germany, South-Africa and elsewhere.