RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pricing Policies and Control of Tobacco in Europe' in the context of a Seventh Framework call.

assistant: **Objectives**

Price is the single most important intervention in tobacco control (TC). To protect the health of its citizens the EU now has a major role in regulating tobacco fiscal policy (FP) through a number of EU directives. The aims of these directives initially were to ensure the proper functioning of the internal market. The directives aided harmonization in EU Member States (MS) but now with EU enlargement price differentials have increased problems for the market and health protection. Price elasticity of tobacco is estimated using econometric analysis of demand but is limited in MS by availability of relevant data. The interaction of FP with other TC policies is poorly defined. The effects of price on smuggling and the tobacco industry response to price changes are complex. Gradually tools are evolving to look at some of these problems. The World Bank has produced a toolkit for economic analysis of tobacco demand with clear guidance on methodology. SimSmoke has allowed the analysis of various TC components to be investigated. This project allows us to perform an econometric analysis at EU level with routinely collected aggregated time series data examining differences in EU MS and the influence of EU border countries. A new cross sectional survey will provide standardised data for EU MS   We will examine the effect of the rate of price changes using historical data comparing steep rapid changes e.g. in France with gradual changes in e.g. UK and Ireland. Using SimSmoke we will examine the effects of the interaction of price with: Smoking Cessation Services, Smuggling in high, (Finland, Ireland, UK) and low, (Baltic, Romania) price countries, Smoke free laws (Ireland, Scotland and Italy), Advertising and warnings (Belgium, UK) and predict the effects on other MS. Outputs: Rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biomarkers in age-related macular degeneration' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Age-related macular degeneration (AMD) is the leading cause of blindness in all populations of European origin with a large socio-economic impact on health systems. Better understanding of the disease should allow to improve diagnosis and disease monitoring and to develop new therapies. Aging and genetic predisposition are the most important risk factors for AMD. Many of the risk genes code for proteins of the innate immune system. Consistently, altered blood concentrations of immune-proteins have been detected in AMD strongly suggesting that such proteins can be used as biomarkers for AMD. Other proteins have also been found to be altered in AMD. We hypothesise that a combination of biomarkers, such as complement activation products, cytokines and elastin degradation products, are highly discriminative for AMD and allow an estimation of disease progression. This would enable clinicians to better allocate personal and financial resources for early identification and therapeutic monitoring of AMD patients at risk. Protein microarray will be used to quantify a large number of biomarkers. Logistic models will define the most relevant proteins and correlation with genetic markers will define biologically meaningful genetic polymorphisms. The relevant proteins will be analysed in blood samples of a large population based cohort. In 2008, all of these patients are being re-examined 6 years after baseline. The six year gap allows a significant number of patients with early AMD at baseline to have developed end-stage AMD, allowing the correlation of baseline systemic biomarkers with disease progression. The relevant biomarkers will furthermore be studied in animal models for AMD in order to better characterize and compare these models regarding systemic alterations observed in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sustainability And Resilience for Infrastructure and Logistics networks' (SARIL).

assistant: **Innovation**

Due to globalized supply chains and the prevalence of just-in-time production, all economies of the industrialized world are reliant on the flawless operation of the logistical network. During the Cov19 pandemic it became apparent that this network can be massively shattered and that a better understanding of its robustness, risks and vulnerabilities is of vital importance. Additionally, it is obvious that the accelerating climate change demands a much greener fright transport.SARIL aims to complement the classic definition of resilience, which focuses on threat prevention, robustness and system recovery, by green aspects. Key performance indicators will be defined which quantify both, the system resistance against disruptions as well as the environmental burden of freight transport. Adopting three different scenarios on different geographical scales (regional, national and international/EU), models will be developed which are able to capture the unperturbed system operation as well as the behavior in case of a disruptions. While the regional (Italy) and national (Spain/Portugal) scenarios focus on natural hazards which become more threatening due to climate change, the international scenario (Northern/Central Europe) considers the disruptions due to pandemics (like Cov19) or wars (like the Russian war against Ukraine). Although the three scenarios will be modelled with varying levels of detail, SARIL aims at a universal understanding of green resilience by using a common framework.The results for the three scenarios will be used to assess similarities and differences between the three geographical scales. By exploiting the findings, recommendations to improve the classic resilience, like e.g., synchro-modal approaches, will be derived. Additionally, SARIL aims for reco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Enabling comprehensive effective and efficient protection and restoration measures for a resilient Baltic Sea ecosystem'.

assistant: **Objectives**

The EU Biodiversity Strategy (BDS) requires expanding the spatial coverage of marine protected areas to 30%, with 10% strict protection. Achieving the current 14-17% coverage has taken the Baltic Sea region 30 years, and strict protection remains almost non-existent. To meet the BDS target the countries will have to double the coverage in just 8 years. To fully capitalize on the added value of increased coverage, designation, management and measures, including restoration, need to be done in a strategic, ecologically relevant way focusing on areas and measures which enhance the existing network and optimise the possibility to secure positive biodiversity outcomes.  There are however substantial challenges facing the region when it comes to leveraging the full potential of upcoming protection and restoration efforts and ultimately, positive biodiversity outcomes, especially in such a tight timeframe.To ensure that the upcoming efforts are both effective and efficient, this transboundary, network level, biogeographical region scale project will:- develop infrastructure for, and ensure long term access to, an unparalleled data driven, ecoregion scale, evidence base to support strategic planning, measures and management;- develop a blue print for, and establish, a data driven, regionally agreed protection framework to improve governance and transboundary cooperation, including politically agreed shared conservation and restoration objectives, targets etc to reach the desired state;- identify the current baseline of protection efforts across the entire sea basin.- cross-reference the desired state with the current baseline to identify gaps in protection and restoration efforts;- provide concrete and replicable support to ensure capacity for the Baltic Sea MS to strategically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Euco-cc3' (EUCO-CC3) under Fifth Framework.

assistant: **Objectives**

The European Conference on Computational Chemistry is the official conference of the Working Party of Computational Chemistry (WPCC) of the federation of European Chemical societies. The first meeting (ECCC-1) was held in Nancy, France (1994), the second one (EUCO-CC2) in Lisbon, Portugal (1997). On the basis of the big success of these conferences (each time about 200-300 participants from all over Europe) WPCC decided to organise the next meeting (EUCO-CC3) in Budapest.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'User friendly face access control system for physical access and healthcare applications' (U-FACE), addressing dissemination and exploitation.

assistant: **Impact**

UFACE will apply emerging facial biometric methods to access control for physical access and healthcare (patient records). Recognition by the face has advantages over fingerprints, iris, etc. It is natural, culturally acceptable and easy to use unlike passwords or tokens, which are forgotten, lost or shared. An existing biometrics, which meets low security needs, will be enhanced to work on a wider range of facial variation (age, physiological state, etc.). A full prototype physical access control systems will be developed and assessed and two healthcare mock-ups will be developed for assessment by captive end users using an existing medical network. Full demonstrator based on the most promising mock-up will be built around a standards-based API. The partners are a research lab, a technology transfer company with expertise in the method, a smartcard supplier, a medical network company with experience in systems for the elderly and disabled, an organisation using the network and an end-user hosting the physical access control site. Objectives:To develop and demonstrate user friendly secure access control in financial services and healthcare. A facial biometric will be combined with a smart-card to create a personalised token. This will be integrated into the emerging biometric interface standards. Application demonstrators will show the advantages over current systems: more secure, less risk of unauthorised access and abuse, increased user acceptance, reduced cost and inconvenience.The precise objectives are:1) to develop new methods for the modelling of variation in facial appearance. These will be provided as a set of software routines,2) to improve reliability and ease of use,3) understand implementation and administration issues, by workshops and feedback from users
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Discover the physiological and developmental functions of X chromosome dosage using new genetic and system models' in the context of a Horizon Europe call.

assistant: **Objectives**

Sex chromosomes are critical for controlling the phenotypic differences between males and females. However, they also create an imbalance in the gene products of sex-linked genes, with males having only one copy and females having two copies. To counteract this imbalance, many species evolved a chromosome-wide mechanism known as dosage compensation, which helps equalise gene expression between the sexes. This process is vital, as failed dosage compensation can lead to sex-specific disorders and lethality in several species including humans. Although researchers have made significant progress in understanding the mechanistic basis of dosage compensation, the core questions remain unanswered: why is the lack of X-chromosome compensation lethal and what are the physiological consequences of its absence? The proposed research aims to identify the mechanisms underlying X monosomy-associated lethality by studying the genes, cells, and developmental processes sensitive to X chromosome doses. This question has been poorly investigated partly due to the difficulties of studying sex chromosome effects. To overcome this barrier, we will investigate flies as these permit the remarkable possibility of generating mosaic animals where sex chromosomes can be genetically manipulated in defined organs, and consequently, functional and molecular analysis.Here, I will combine classical fly genetics, two novel model systems and cutting-edge genomic techniques to:1. Identify the functions of X chromosome dosage in fly development.2. Characterise the ancestral X chromosome compensatory system of all insects.3. Discover the general shared functions of sex chromosome dosage in development using new insect model species. Thus, results from this research should have a major impact on our understa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'An astronomical perspective on Earth's geological record and evolution of life'.

assistant: **Objectives**

This project will develop the use of relict, extraterrestrial minerals in Archean to Cenozoic slowly formed sediments as tracers of events in the solar system and cosmos, and to decipher the possible relation between such events and evolution of life and environmental change on Earth. There has been consensus that it would not be possible to reconstruct variations in the flux of different types of meteorites to Earth through the ages. Meteorite falls are rare and meteorites weather and decay rapidly on the Earth surface. However, the last years we have developed the first realistic approach to circumvent these problems. Almost all meteorite types contain a small fraction of spinel minerals that survives weathering and can be recovered from large samples of condensed sediments of any age. Inside the spinels we can locate by synchrotron-light X-ray tomography 1-30 micron sized inclusions of most of the other minerals that made up the original meteorite.  With cutting-edge frontier microanalyses such as Ne-21 (solar wind, galactic rays), oxygen isotopes (meteorite group and type) and cosmic ray tracks (supernova densities) we will be able to unravel from the geological record fundamental new information about the solar system at specific times through the past 3.8 Gyr. Variations in flux and types of meteorites may reflect solar-system and galaxy gravity disturbances as well as the sequence of disruptions of the parent bodies for meteorite types known and not yet known. Cosmic-ray tracks in spinels may identify the galactic year (230 Myr) in the geological record. For the first time it will be possible to systematically relate major global biotic and tectonic events, changes in sea-level, climate and asteroid and comet impacts to what happened in the larger astronomical re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'ZEolite synthesis in Unusual Reactors for Enhanced CAtalysts'.

assistant: **Objectives**

Approximately 9 out of 10 chemical processes use a solid catalyst, as they increase the efficiency of chemical reactions while being recyclable. Zeolites are one of the most iconic types. These porous crystalline oxides are built from networks of aluminum and silicon nodes and are characterized by regular pores with dimensions similar to most of the molecules that sustain modern society.Although zeolite synthesis is essentially an assembly of silica and alumina around positively charged template molecules, the outcome heavily depends on kinetics. Yet, classic reactors and strategies barely allow any fine-control over the kinetic interplay, and thus the zeolite made, due the complex and not well understood role of Coulomb and other interactions among the assembling species, and their concentration profiles. Even for established catalysts, synthetic control over their key properties is often lacking. However, such fine-control is essential to develop better catalytic processes in the light of global challenges.Z-EURECA wants to revolutionize zeolite synthesis, not by the usual search for ingredients, but by introducing new reactor-based handles, specifically external electric fields and fed-batch modes, to exert control over kinetic pathways. Based on new reactor designs, active manipulation of the various Coulomb and interspecies interactions and local concentration gradients during synthesis will be possible.This bottom-up revolution will i) provide missing insights into the fundamentals of relevant zeolite synthesis, ii) develop active tools that engineer access to synthetic fine-control over zeolites and iii) validate this fine-control in relevant catalytic reactions for superior acid and redox zeolites in prominent sustainable catalysis challenges of our resource-hun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Structure of Herpesviral cell access' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Membrane-bound proteins play several important roles in biological processes and viral infections make no exception. Especially for enveloped viruses, where the virion-mediated fusion with the target membrane starts the infection cycle and insights about the viral membrane proteins acting as fusion machineries provide targets for drug design. Human cytomegalovirus (HCMV, a member of the enveloped Herpesvirus family) is a widespread highly adapted human pathogen, representing the leading infectious cause of congenital brain defects and a major source of life-threatening complications in transplant recipients and immunodeficient individuals. HCMV is also associated to cancer progression and to the immunosenescence. Licensed drugs for anti-HCMV treatment are characterized by weak activity and high toxicity, and alternative viral targets must be found to develop novel therapeutic strategies. The herpesviral fusion machinery presents an unusal complexity with four up to seven viral proteins involved. A dynamic molecular model of the fusion mechanics is still lacking for HCMV, and a structural description of fusion players is completely absent, thus preventing the rational design of HCMV fusion inhibitors. The present project aims to the structural investigation of HCMV fusion machinery by its in vitro reconstitution with the purified viral players and their crystallisation for structure determination by X-ray diffraction. Molecular biology of the HCMV entry is the current subject of the researcher proponent. The hosting scientist, with a well established espertise in structural studies of membrane proteins and as part of international collaborating networks devoted to foster knowledge and dissemination in the field, will provide the appropriate training environment to develo