RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Advancing a GMMA-based vaccine against invasive non-typhoidal salmonellosis through Phase 1 trial in Europe and sub-Saharan Africa'.

assistant: **Objectives**

Invasive non-typhoidal Salmonellosis (iNTS) is an important emerging Neglected Infectious Disease in resource-poor settings of sub-Saharan Africa (sSA). No vaccine is currently available. Estimated 263,000 iNTS deaths per year in <5 year olds, a 20% case fatality rate, difficult diagnosis and increasing antibiotic resistance strongly advocate for rapid development of an effective vaccine. Vacc-iNTS bridges the gap between preclinical and early clinical development of a novel vaccine against iNTS, based on GMMA (Generalized Modules for Membrane Antigens) from the most common African iNTS serotypes (Typhimurium and Enteritidis). The highly cost-effective GMMA-technology, developed by partner 2, is based on outer membrane blebs released by genetically modified bacteria. Clinical proof-of-concept for the GMMA-technology was achieved with a Shigella sonnei vaccine in European and African adults. In animals, iNTS-GMMA were highly immunogenic and induced antibodies with bactericidal activity against African iNTS strains. Simple, robust and scalable manufacturing processes for iNTS-GMMA, suited for sSA, have been developed. Vacc-iNTS proposes GMP manufacturing of clinical lots followed by a two-stage Phase 1 trial in healthy European and African adults to investigate safety and immunogenicity of the iNTS-GMMA vaccine. Analysis include serum antibody levels and functionality, cellular responses, transcriptomics and data integration through a systems biology approach. Sero-epidemiological analysis will be conducted to provide essential data for future Phase 2 and 3 trials.  Vacc-iNTS will also strengthen a collaborative network of iNTS experts from academia, industry and non-profit including partners from disease-endemic countries of sSA. The network will generate data to acceler
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Role of Adipose DPP4 Deletion in Diet-Induced Obesity'.

assistant: **Concept**

Dipeptidyl peptidase-4 (DPP-4) is an exoprotease that cleaves N-terminal dipeptides from several substrates such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GLP), impairing the function of the incretin system, which is of key importance for glucose homeostasis. Indeed, DPP4 inhibitors are currently in clinical use for type 2 diabetes. The host group has described for the first time that DPP4 is secreted by adipose and strongly correlates with adipocyte volume and parameters of the metabolic syndrome and is decreased to the lean level after weight reduction in humans. Moreover, novel data obtained in the host group suggest that DPP4 may impair insulin sensitivity in an auto- and paracrine manner. Thus, DPP4 arises as a novel adipokine potentially linking obesity to the metabolic syndrome. Since there is a growing interest in anti-diabetic therapies based on DPP4 inhibition, a deeper understanding of the role of adipose DPP4 on the onset and progression of insulin resistance is needed. This project aims to explore the impact of adipose DPP4 deletion in diet- induced obesity (ADDIO). For this purpose the host group is generating an adipose-specific DPP4 knockout mouse to prove a causal roleof this protein in the development of the metabolic syndrome. Our global aim will be pursued following a 3 step strategy: Firstly, we will assess the impact of adipose DPP4 genetic deletion by characterizing the metabolic phenotype of adipose-specific DPP4 knockout mice.We will next determine the impact of genetic deletion of adipose DPP4 on the development of diet-induced impaired glucose tolerance and insulin resistance. Finally, we will explore the mechanism responsible for the potential protective/delaying effect of adipose DPP4 genetic deletion on impaired
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'SCALING UP CAPACITY TO SUPPORT CONDUCT OF CLINICAL TRIALS IN THE EAST AFRICAN COMMUNITY'.

assistant: **Concept**

The East African Community (EAC) has experienced significant increase in volume and complexity of clinical research driven by epidemics of emerging and remerging infectious diseases such as HIV, Ebola and COVID-19, requiring expertise in scientific and ethical review and conduct of research and a robust and pragmatic research regulatory framework. The overall goal is to strengthen scientific and ethics capacity in EAC for high quality research review, conduct and oversight, at international standards. The specific objectives are: 1. To train NRRA personnel, REC members, researchers and clinicians on scientific and ethics review and conduct of research with emerging and complex study designs including adaptive platform trials 2. To train NRRA personnel and REC members on oversight, monitoring and pharmacovigilance of clinical trials and 3. To train NRRA personnel, REC and research administrators on personal effectiveness and leadership skills (PELS) to manage the increasingly complex research processes. Methods: We will implement this project within a consortium of research scientists from the six partner states collaborating with the EU partner, with the East African Health Research Commission as the strong nucleus for coordination and dissemination of results. The project will be hosted at the Infectious Diseases Institute (IDI), where within a previous NIH funded program (5G11 TW011309-01) we built capacity for REC members, researchers and REC administrators for 7 RECs in Uganda, with significant improvement in knowledge, PELS, quality and turnaround time of research review and researcher satisfaction. This proposal fits within the scope of GH-EDCTP3-2022-01-05 call, whose aim is to strengthen clinical research capacity and improve efficiency of the regulatory environ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'New approaches to low-temperature curable coatings for powder and decorative applications'.

assistant: **Objectives**

In LOTEC new concepts for high-performance, low-temperature curable coatings will be developed. In a first approach, new radiation-curable materials will be developed that can serve as binder systems for powder coatings. The saroe material concepts will then also be used to develop new binders for radiation-curable water-based decorative coatings. Other, more innovative approaches to water-based decorative coatings will also be investigated, based on 2-component technology. LOTEC will lead to high-quality coatings that combine positive energy aspects (low temperature curable), environmental aspects (0% solvent) and working conditions aspects (no neurotoxic vapours).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Revealing the RNA-LNP ultrastructure and subcellular trafficking using advanced Cryo-electron microscopy and proteomics' (CryoLipNano) under Horizon Europe.

assistant: **Objectives**

RNA therapeutics are revolutionizing medicine, offering new treatment possibilities for diseases once considered undruggable. Central to the delivery of nucleic acids, especially mRNA, is the use of Lipid Nanoparticles (LNPs) – the most advanced and the only clinically approved gene delivery platform. LNPs protect mRNA from degradation, facilitate its transfer, and ensure delivery into the cell. Despite their potential, the therapeutic potency of RNA-LNPs remains limited due to suboptimal RNA delivery, with <10% of the administered RNA-LNP system reaching the cytoplasm. To this end, crucial gaps persist in our understanding of LNP structure, integrity and their impact on trafficking and RNA delivery.  CryoLipNano aims to advance our knowledge on LNP ultrastructure and intracellular dynamics, by linking – for the first time – lipid composition, morphology, LNP integrity, mRNA localization and trafficking after endocytosis. By integrating physical chemistry with cutting-edge cryo-electron microscopy (cryoEM), advanced imaging techniques, and proteomic analysis, this study will address critical knowledge gaps, ultimately leading to the rational design of second-generation LNP platforms with enhanced efficiency and potency. Moreover, CryoLipNano will establish the first RNA-LNP research hub at the host institute and, alongside with the ERA Chair's launch of the country's first cryoEM facility, will create a new line of expertise in RNA-LNP characterization by cryoEM. This expertise will be valuable not only in Greece, but also for entities across Europe and globally. CryoLipNano will also focus on disseminating the lab’s presence, educating the scientific community and the public about RNA therapeutics and their structural analysis, and inspiring young scientists. Finally,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Innovative 3D electro-printing method to improve power, capacity and safety of lithium ion-batteries' (Addionics), addressing dissemination and exploitation.

assistant: **Impact**

We are currently experiencing one of the most dynamic shifts in the history of modern transportation. With a continuousdecrease of oil resources, increase in number of cars and the growth of tail gas pollution, more and more countries began tothe importance of Electric Vehicles (EVs) by setting ambitious sales targets. EU transportation sector has committed to a60% reduction in green-house gas emission by 2050. However, despite the growth of the EV market, the development in thebattery has been only incremental, without massive breakthroughs, since 1991 when Sony launched first commercialLithium-Ion batteries.Addionics innovative technology and materials can create Li-ion batteries with higher capacity, power and energy density.Using unique 3D electro-printing method, and easy manufacturing process, Addionics will enable longer EV battery life,shorter charging time and higher safety.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Low temperature catalytic methane decomposition for COx-free hydrogen production' (112CO2) targeting Horizon 2020.

assistant: **Abstract**

The world needs a disruptive technology to very quickly decarbonize the energy; the success of this technology depends heavily on its social acceptance, sustainability and fast and easy implementation. The proponents of 112CO2 believe to have this technology. Imagine that a new chemical reactor would make possible to use methane, an easy to transport and to store fuel, either fossil, renewable or synthetic, for producing COx-free hydrogen in a cost-effective way. Imagine that this approach could be implemented swiftly, taking advantage of the present infrastructure. 112CO2 project is about producing hydrogen from low temperature methane decomposition (MD), a 100 % selective reaction – CH4 → C (s) + 2 H2. The use of methane from biogas allows actively to remove CO2 from the atmosphere (negative carbon balance) but, if using fossil methane, there will be no COx emissions. 112CO2 project aims at developing a low temperature MD catalyst, easy to regenerate and very active, > 0.45 gH2/gCat/h and stable for at least 10 000 h. 112CO2 proposes an innovative regeneration step based on the selective hydrogenation of the carbon attaching interface with the catalyst, allowing to release the coke particles and the recovery of the catalytic activity. Proponents succeed very recently to demonstrate, in a 500-h experiment, that this approach is possible and easily accomplishable. A membrane reactor, made of a stack of individual cells for producing hydrogen and a stack for pumping out this fuel cell grade hydrogen, will be developed for running at ca. 600 °C and to display > 0.05 gH2/cm3/h, an energy density comparable to the PEMFC. The proposed MD reactor is suitable for mobile as well as for stationary applications.112CO2 project proposes also an ambitious communication strategy, aim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Quantitative Approach for Smart Parking' (QPARK).

assistant: **Concept**

Ubiwhere has been commercialising a low-cost, seamless and straightforward-to-install system entitled Smart Parking, composed of vehicle-detection electromagnetic sensors and an intelligent software platform to collect and process all the data. Through this system, parking operators can enhance their ongoing operations by knowing in every instance what is happening and by analysing reports on the behavioural patterns detected by the platform, improving their operational and enforcement efficiency.The potential market of Parking has increased the number of competing solutions in this sector (despite the lack of a market leader), composed of both ICT startups and well-established companies. With so many competitors, and taking into account that several cities have started to dismantle the spaces reserved for parking in their urban areas, Ubiwhere intends to enrich its Smart Parking platform with urban planning capabilities, unlocking a new business opportunity and consequently standing out from its competitors.QPARK aims at up-scaling the current Smart Parking solution, enriching it with a new service (feature) that enables the generation of reports via a thorough analysis of which areas of the city are more affected by certain events and how that sudden increase in people affects the city traffic and the parking occupancy. The FET Open project QUANTICOL will support this what-if analysis by providing the necessary tools and mechanisms to advance in the problem space and provide useful knowledge quickly.QPARK will allow Ubiwhere, a software company focused on Smart Cities and Communities, to disrupt the global market by enriching its solutions with urban planning capabilities, powered by complex adaptative systems developed in QUANTICOL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hidden role of the meiotic chromosomal bouquet' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Organisms diversify and propagate their genomes throughout successive generations through the process of meiosis. Understanding the process of meiosis is important, as defects in meiosis are a major cause of miscarriages in humans. In meiotic prophase, telomeres gather near the microtubule organizing-center (MTOC) to form the so-called ‘bouquet’ structure. The extraordinary conservation of the bouquet has suggested that it plays an important role in promoting successful meiosis. My recent work revealed that bouquet formation plays crucial role in regulating the meiotic MTOC and spindle. This discovery raises a number of questions that bear on the relationship between chromosomes and the spindle apparatus.I propose that the chromosomal bouquet is a novel sensor system to monitor progression of meiotic prophase including meiotic recombination, which are required for meiosis I. Completion of these chromosomal events may be signalled from chromosomes to the MTOC to finish bouquet formation.  Such chromosome dynamics may be involved in proper formation of the spindle at the later phase, meiosis. I will therefore elucidate how the end of the bouquet is regulated and how such a event affects function of the MOTC using fission yeast as a model organism. Chromosomal components, structure and dynamics in fission yeast are highly conserved among higher eukaryotes.  In particular, telomere functions are often reproduced in higher organisms. I will investigate molecular mechanisms using molecular biology and a live cell imaging technique along with yeast genetics. Revealing this communication mechanism will be crucial to our understanding of the meaning of the chromosomal bouquet, and will also provide a fundamental insight into meiosis regulation and chromosome function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Flexible and on-demand manufacturing of customised spectacles by close-to-optician production clusters' to be submitted under Seventh Framework.

assistant: **Abstract**

Optician2020 will develop distributed manufacturing assets in mini-factories clustered in urban areas combining short series manufacturing technologies and ICT tools for design, process automation and on-line real time delivery management of personalised spectacles, a fashionable product combining health prescription, functional performance and aesthetical requirements. The key enabling technologies to be deployed are:- additive manufacturing, for polymeric and metallic frames- advanced coating technologies, for short series lens coating- automated procedures, for personalisable frames catalogue design- scanning devices, for end-user anthropometric data captureICT tools will be used to improve the efficiency, adaptability and sustainability of the production systems and their integration within the proximity mini-factory business model. It requires continuous change of processes related to the management of distributed manufacturing assets and to the personalised manufacturing of spectacles in which the consumer can select frame materials and also finishings both in frame and lenses.Optician2020 will demonstrate the feasibility of this business model based on close-to-optician mini-factories by showing:- The spectacles personalisation flexibility, developing a catalogue of at least 12 models in spectacles for 450 users.- The mini-factories flexibility and re-configurability with an agile procedure for adding new local manufacturing facilities to the open virtual network.- The time-to-market reduction up to 65% and production cost reduction of 40% with respect to conventional methods.The exploitation will start one year after the completion of Optician2020. A maximum initial impact of 25.000 spectacles can be obtained with two initial clusters of networked minifactories
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Ground-breAking collaboratioN framework realizing the next era of cybercrime Detection And muLti-stakeholder investigation For LEAs, judicial ecosystems, and citizens.' under Horizon Europe.

assistant: **Concept**

In order to address the fast-evolving challenges with respect to advanced forms of cybercrimes enabled by fully available state-of-the-art technologies (Crime-as-a-Service), there is a need for LEAs to form and apply cutting-edge collaboration frameworks that will break communication silos within the wider judicial ecosystem. These frameworks may span in numerous pillars, such as (i) regulated, privacy-preserving and easy sharing of information related to criminal activities enabling cross-border agency-to-agency collaboration in a transparent and explainable manner; (ii) joint criminal investigation further facilitated by beyond state-of-the-art tools enabling real-time collaboration and the full exploitation of distributed digital infrastructures to enhance cybercrime intelligence; (iii) exchanging different types of expertise (cybersecurity experts, forensics experts, lawyers and stakeholders from the judicial ecosystem, psychologists, social scientists) to realise cutting edge investigative approaches; and (iv) knowledge and best practices sharing with respect to trainings and cybercrime awareness. GANNDALF will set new grounds for the fight against advanced forms of cyber threats and cyber-dependent crimes; it will (i) realise cutting-edge agency-to-agency data sharing mechanisms, optimising the balance between transparency and privacy based on the needs of each LEA; (ii) deploy a modular, decision-support toolbox that will comprise not only ground-breaking technologies for collaborative investigation, prediction and identification of advanced forms of cyber threats, but also optimisation mechanisms enabling the full exploitation of these technologies; (iii) build on the above 2 offerings and deliver a customizable, collaborative crime investigation sandbox for sce