RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'An aptamer-based multiplex assay to recording molecular signatures of cancer cell fingerprints'.

assistant: **Objectives**

The ability to detect pathogenic cells is essential for many applications in clinical diagnostics. Great attention has been focused on the field during the last decade, stressing the importance of an early and unequivocal detection of certain diseases for a successful diagnosis and thus, a favourable treatment and prognosis. To achieve this, molecular tools are required that unambiguously recognise appropriate cell surface molecules that come along with disease onset and progression. Aptamers are short single-chained oligo(deoxy)nucleotides that interact with cognate target molecules with high affinity and specificity. Within the last years they gained much attention to be employed as cell–recognition tools. In this research proposal, DNA aptamers that reveal broad-spectrum interaction patterns with cancer cells derived from solid tumours will be employed for developing a robust, multiplex assay format likely to determine molecular fingerprints of the most prevalent and lethal cancers worldwide. Furthermore, the multiplex aptamer-based assay will allow gaining information of the relative expression levels of yet unknown marker proteins present on different cancer cells. This will enable profiling of cancer cells, which is highly convenient for diagnostic monitoring. A second goal is the identification of the molecular targets of the employed aptamers. This will be achieved by using siRNA libraries, essentially covering the entire human genome and the knockdown of putative target molecules. Loss of aptamer binding in relation to employed siRNA molecules will lead to information on cognate aptamer target molecules, and they will be studied as possible new biomarkers candidates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Technologies for Supporting Online Music Education' (TECSOME) targeting Horizon 2020.

assistant: **Abstract**

Online learning has impacted and changed music education significantly all over the world in the last decade. Music schools and teachers have now access to a much wider audience, increasing their business opportunities specially by overcoming the geographical constraints. However, online music performance education cannot scale to MOOC level given that the student assessments rely on individual instructor review, as is the case in the well known online courses from Berklee Online. The need of a personal assessment procedure limits the growth and expansion of these courses.Our project, TECSOME, will solve this limitation by facilitating the learner’s assessment, making it more automatic and less human-dependent. We will build an automatic assessment system, named Music Critic, around a set of technologies developed within the CompMusic project, targeted at supporting music performance courses and helping them scale up to MOOC level. Music Critic will act as an external assessment tool able to communicate with existing Learning Management Systems (LMS) via the Learning Tool Interoperability standard (LTI). The basic workflow will be: (1) teacher prepares an exercise using the LMS and Music Critic; (2) learner uploads an audio recording of the exercise to the LMS; (3) LMS sends the audio recording to Music Critic, where is analyzed and evaluated; and (4) Music Critic sends the assessment outcome, which includes the evaluation grade and detail feedbacks, to the LMS, where it can be corrected and validated by the teacher before becoming available to the learner. In the CompMusic project we have developed technologies with which to analyze music recordings in various music styles. Some of the technologies are already being exploited in a PoC project, CAMUT, which takes advant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Research & Innovation Days: High-level conference: Institutional Philanthropy Supporting Science, Research and Innovation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

As a leading platform for philanthropy in Europe, the EFC works to strengthen the sector and make the case for institutional philanthropy as a formidable means of effecting change.We believe institutional philanthropy has a unique, crucial and timely role to play in meeting the critical challenges societies face. More people and causes benefit from institutional philanthropy than ever before, from eradicating deadly diseases and making the world’s populations healthier to combating climate change and fighting for global human rights and equality.Working closely with our members, a dynamic network of strategically-minded philanthropic organisations from more than 30 countries, we:Foster peer-learning by surfacing the expertise and experience embedded in the sectorEnhance collaboration by connecting people for inspiration and joint actionAdvocate for favourable policy and regulatory environments for philanthropyBuild a solid evidence base through knowledge and intelligenceRaise the visibility of philanthropy’s value and impact


**Keywords:** Horizon Europe – research and innovation – partnership – conference – co-creation – philanthropy – foundations – funding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '99mtc labelling and preliminary evaluation of rc 160' (1994-1998).

assistant: **Innovation**

Research objectives and content Summary: The use of radiolabelled neuropeptides is a new and exciting development in nuclear medicine for oncological applications but radiolabelling of highly specific small biomolecules like peptides with the metal Technetium-99m, the isotope of choice for nuclear imaging without changing their biological properties is a great challenge to the radiopharmaceutical scientist. RC-160, a somatostatin analogue, seems to be an important alternative to the recently developed 111 In labelled Octreotide for the targeting of certain cancer types (in particular for pancreatic adenocarcinomas and brain tumors). The aim of the project is to label RC-160 with 99m Tc using conjugation with bifunctional chelating agents and to evaluate its biochemical and biological behaviour. The radiolabelled peptides will be tested for labelling efficiency, purity and stability. Their affinity for the somatostatin receptor sub-types will be determined using binding assays on different tumor cell lines and cell homogenates. Animal biodistribution of promising candidates in mouse and rat will be investigated. This work will add substantial data to 99m Tc-labelling of peptides as well as the action, relevance and expression of somatostatin receptors in tumors in vivo. Training content (objective, benefit and expected impact) The applicant will learn new techniques necessary for the development of new radiopharmaceuticals; peptide chemistry, radiolabelling methods for biomolecules, methods for radiochemical analysis, radioligand binding assays and biodistribution studies in animals. This training effect will be of great value for this future career and the home institute, where this kind of research can be continued. Links with industry / industrial relevance (22) This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Stereoselective total synthesis of hydroxycornexistin using  domino" metathesis reactions"'.

assistant: **Innovation**

Mr. Bastien Nay defended his PhD's work at the end of 2000 and the research program he had to execute was quite a difficult one since it was dealing with the total synthesis of 13C-labelled flavanols. I can confirm that he never disappointed me. To give you frankly my opinion, I would tell that Mr. BastienNay is a very clever student and most probably the most skill full among the 16 PhD students I ever had working at the bench under my direction. Long before the end of his thesis work, he was able to have an overview" of his chemical results and to compare them with the main results appeared in the literature in the field as well as in related other ones. The main results he obtained in chemistry of polyphenols (large scale enantioselective total synthesis of isotopically labeled polyphenols) appear unambiguously in the papers he already published to Tetrahedron Letters and to Eur. JOC. To my opinion, the approach he developed, is the first one that makes these molecules available at a sufficient enantiomeric purity and in sufficient large amounts to allow experiments in human. One of the published work in Eur. J.O.C., even though in a racemic form of labeled catechin was attractive enough to other important laboratories from various countries to make them getting in touch with us in order to start fundamental collaborative work in human nutrition field. These molecules are very interesting tools for the scientific area concerned by physiological peroxidations. The better understanding of pathological states generated by free oxygenated radicals in human (cancers, cardiovascular diseases, Alzheimer,) deeply depends on such tools. Bastien NAY is able of so many efforts to adapt himself to a new topic and he is so skilful in organic chemistry, that I am sure he will take
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Designing a Novel Protein Inspired Therapeutic Against Xylella' under Horizon Europe.

assistant: **Concept**

This project aims to develop an innovative protein therapy to combat Xylella fastidiosa (Xf), a plant pathogen causing significant economic losses in high-value crops such as olive, grapevine, almond, and blueberries.Xf has particularly impacted agriculture in the Mediterranean Basin, with the widespread decline of ancient olive groves in southern Italy serving as a prominent example. Current management strategies are ineffective, underscoring the need for novel disease control solutions - an issue central to the MultiX grant on Xf virulence and plant immunity.Our key inventive step is based on the hypothesis that the phytomicrobiome of a non-host plant contains factors that inhibit Xf. Through experiments and proteomics, we have identified a protein that demonstrates inhibitory activity against Xf. This protein shows significant promise and, with further refinement and optimization, could be developed into an effective therapy.Building on this discovery, PROTaX will design an effective therapeutic and demonstrated its potential to manage Xf infections. Furthermore, we will have gained a deeper understanding of market interests.


**Keywords:** Xylella fastidiosa, microbiome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Uncovering neurobiology of transdiagnostic oral language development' under Horizon Europe.

assistant: **Concept**

Understanding and producing language are uniquely human abilities that rely on distributed neural networks and develop over many years. Language disorders including developmental dyslexia and Developmental Language Disorder (DLD) disrupt these processes in distinct ways: dyslexia primarily affects phonological processing and decoding, while DLD impairs broader oral language skills, including grammar across comprehension and production. Both disorders are multifactorial and overlapping, sharing deficits in reading/writing and vocabulary, yet their neural bases remain poorly understood. Most neuroimaging studies investigate only one disorder, overlooking comorbidities and the influence of bilingualism. Bilingual children display individual language profiles, currently leading to being over- and under-identified for DLD or dyslexia services.In this project, we will recruit 120 Basque-Spanish bilingual children aged 8 to 10 years, spanning DLD (N=40), dyslexia (N=40), comorbid DLD+dyslexia (N=20), and controls (N=20). Exclusion criteria include other neurodevelopmental disorders and low nonverbal IQ. Multimodal MRI will capture structural and functional neural profiles, which we will analyze to: (1) test hypothesis-driven predictions based on diagnostic categories while controlling for bilingual experience; (2) apply machine learning to identify multivariate brain-behavior relationships; and (3) adopt a transdiagnostic approach to examine variability in neural and behavioral profiles independent of diagnostic labels.The Uncovering Neurobiology of Transdiagnostic Oral Language Development (UNTOLD) project enables direct comparison across disorders, disentangling shared and disorder-specific neural mechanisms while explicitly incorporating bilingualism as a core factor. Findi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'La relacion entre los sistemes de marcas comunitario' under Fourth Framework.

assistant: **Concept**

The individual harmonised trade mark law of each Member State and the Community Trade Mark (CTM) system are designed to co-exist and work together. The Harmonising Directive contains provisions that recognise CTM rights. Likewise, trade mark rights created by individual Member States are recognised in the CTM Regulation. Hence, the proposed project aims to define the relationship between the CTM and the national trademarks, as well as to investigate the mechanisms provided to reduce the conflicts which may arise between them, as much as the instruments which tend to promote the access to the CTM system. These are also problems concerning the interrelationship between the CTM system and the existing Madrid Arrangement. Threatened by the CTM system, the World Intellectual Property Organization, administrator of the Madrid Arrangement, promulgated a protocol (the Madrid Protocol) to create a deposit-type system that would eliminate the Madrid Arrangement's problematic features. The Madrid Protocol provides a link between the Madrid Arrangement and the CTM system. In spite of these link, there is still discussion concerning the viability of a CTM and the need for the CTM system in addition to the Madrid Protocol. The investigation that I mean to accomplish aims to demonstrate that a perfect co-ordination between the refereed systems may be attained. This result should, then, have a notable influence upon the planification of the entire strategy of international protection of trademarks, both inside and outside the European Community There is still discussion concerning the future viability of the CTM system. Yet, in our opinion, a righteous understanding of the co-ordination between the community system and the Madrid Protocol will show how the co-existing systems can be us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Spin electronics with manganite-based heterostructures', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The recent discovery of colossal magnetoresistance (CMR) in manganese perovskites has boosted research on these compounds. Presently, a too high magnetic field is necessary in these materials to produce CMR, this feature being inadequate for magnetoresistive applications (read heads, sensors,...). The main objective of this project is to introduce manganese oxides into heterostructures in order to obtain giant magnetoresistive (GMR) ratios at very low magnetic fields by using the property of spin-polarized conduction that the manganese perovskites exhibit in the ferromagnetic metallic state. The heterostructures that will be studied include: i) (Manganite/Metal) multilayers for perpendicular GMR effects: the complete spin polarization of the conduction in manganites should lead to much higher effects than in conventional magnetic multilayers (purely metalic). ii) Tunnel junctions of the type (Manganite/Insulator/Manganite): spin-dependent tunnelling between ferromagnetic electrodes is a present 'hot topic' in magnetism. Large tunnel magnetoresistance is expected due to the spin-polarized nature of conduction in manganites. iii) Devices of the spin switch type including manganites: the Spin switch (or Spin transistor) is based on the same spin accumulation effects as the CPP-GMR effects, making that spin switch or other spin injection structures including manganites should be very promising devices. The central idea to apply for a TMR grant is to take advantage of the expertise on bulk manganites at Zaragoza and that at Orsay on magnetic heterostructures (multilayers and other nanostructures). Moreover, it is also of great interest to develop a more general collaboration between two European teams having complementary expertise. Training c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Laser patterning of 3d shaped structures' to be submitted under Fourth Framework.

assistant: **Abstract**

- 5 and 6 - axis excimer laser processing prototype machine built and demonstrated.- prototype system for 3-Dlaser drilling of aerofoils.- Multi-layer conformal pcb laser-based process route demonstrated, including software, on developable substrates.- 4-layer conformal antenna PCB demonstrator fabricated on 6-axis tool.- Novel 3-D Cu etching machine for 3D shaped Printed Circuit Board PCB developed by a third party from specifications (investment not funded by the project).- printer head prototypes and antenna demonstrator produced on 5-axis tool.- New laser processing know-how for the materials used in the project.- Application study to replace UV lamp, light-house exposure in the lithographic steps of CRT production with multi-axis excimer laser exposure, avoiding long lead times associated with the complex lens assembly in the light house.There is a strong industrial need of high precision patterning on 3D preformed structures such as:  printed circuit structures, including multilayer interconnections, molded circuits, sensors and antennae,  machined metal foils such as porous surfaces (aerofoils) or photoimaging tools,  TV display CRT tubes. Present imaging or structuring techniques have a limited potential to be adapted to 3D surfaces and currently limit pattern precision. Laser beams offer higher flexibility and versatility for the patterning of complex shapes. The objective of this project is to develop: (i) a real 3D laser patterning system having the following characteristics: high power lasers (Excimer, CO2 and Nd:YAG) computer controlled workpiece and/or beam handling beam forming and image plane/focal point position control across a 3D shaped substrate process viewing and monitoring and end point detection. CAD machine interface (ii) a 3D electronic CAD too
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Shedding light on the key molecular determinants regulating 3D diffusion and activity of antimicrobials in bacterial biofilms.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Bacterial biofilms are associated with approximately 1.7 million hospital-acquired infections annually in the United States, incurring an annual economic burden of about 11 billion dollars. The role of biofilms in antimicrobial resistance (AMR) is highly complex and may significantly drive resistance. Biofilms can act as a diffusion-limiting barrier against various antimicrobials resulting in limited drug access into the bacterial cells. The evaluation and quantification of biofilm diffusion is essential since it is a poorly researched topic, and the matrix properties are necessary to define the bacterial populations within the biofilm. In this project, an antimicrobial peptide (AMP) will be used as a model molecule because AMPs are known for their activity against biofilms and have been considered promising antibiofilm agents. The vCPP2319, a peptide developed by the Instituto de Medicina Molecular team (iMM), was chosen for the project as a diffusion model reporter. The research plan is organized into three scientific Work Packages (WP). WP1 aims at studying the fundamental properties of biofilms, whereas WP2 and WP3 aim at studies using vCPP2319 and the library of its variants, respectively, as molecular models to elucidate their diffusion-related properties in biofilms and correlate antibiofilm activity with the metabolic status of biofilm-embedded bacterial cells. The project will use two reference and two clinical strains of Staphylococcus aureus and Klebsiella pneumoniae as models. These bacterial species will be selected because they are clinically relevant pathogens frequently associated with biofilm infections. Overall, the project's relevance is overcoming the gap of knowledge associated with molecular diffusion in biofilms and relating the diffusion of antim