RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Aggregated Quality Assurance for Systems' (AQUAS).

assistant: **Concept**

There is an ever increasing complexity of the systems we engineer in modern society, which includes facing theconvergence of the embedded world and the open world. This complexity creates increasing difficulty with providingassurance for factors including safety, security and performance - particularly for safety critical systems such as thetransportation, aerospace and the industrial control domains.In this project we will focus on the following:• Safety/Security/Performance to be considered together, during the overall life cycle of our products.• Flexibility across domains.• Consolidate the industrial market by reducing costs and increasing system quality and maintaining compliance with moreand more exacting standards.• Improved tool features and capabilities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Electro-thermal modelling of lithium-ion battery packs from the safety perspective' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Lithium-ion batteries (LIB) are found in many applications such as consumer electronics, electric vehicles and airplanes. However, LIBs can be dangerous under some conditions and can pose a safety hazard since they contain a flammable electrolyte and are also kept pressurized. Despite the high safety standards being imposed and the embedded safety features, there have been many reported accidents as well as recalls done by some companies. Most accidents can be sourced to run away reactions, which could happen if the LIBs are overheated or overcharged. This is often accompanied by cell rupture and in extreme cases can lead to fire and explosions. The Fellow has conducted her PhD on LIB run away reactions and investigated the effect different anode and cathode materials to enhance LIB safety through modelling, experiments and theoretical study of LIB cell. She will transfer such knowledge to the European host and combine with their extensive expertise in fire and explosion modelling to develop a thermal model to simulate the heat generation and dissipation within the battery pack. The research intends to bridge some important knowledge gaps concerning LIB safety and deliver a predictive tool, which can be used to enhance LIB thermal management from the safety perspective. Such a tool can aid the development of safer LIB cells and the optimisation of LIB packs balancing performance and safety requirement. The specific objectives include:- Develop and validate a thermal model that will predict the onset of runaway reactions (WP1);- Extend the above model to predict potential ignition (WP2);- Further extend the model to predict possible escalation from a single cell ignition to potential fire and explosion hazards (WP3);- Validate the predictions with full scale test data gi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'T6SS MIX-effectors: secretion, activities and use as antibacterial treatment', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Bacteria use various mechanisms to combat competitors and colonize new niches. The Type VI Secretion System (T6SS), a contact-dependent protein delivery apparatus, is a widespread, recently discovered machine used by Gram-negative bacteria to target competitors. Its toxicity is mediated by secreted proteins called effectors, yet the identity of many effectors, the mechanism of secretion of different effector classes, and their toxic activities remain largely unknown. I recently uncovered a widespread class of T6SS effectors that share a domain called MIX. MIX-effectors are polymorphic proteins carrying various toxin domains, many of which with unknown activities.Many bacterial pathogens have acquired resistance to contemporary antibiotic treatments, becoming a public health threat and necessitating the development of novel antibacterial strategies. Thus, as a relatively untapped antibacterial system, studying the T6SS and its MIX-effectors presents a double incentive: 1) previously uncharacterized antibacterial activities of MIX-effectors can illuminate novel cellular targets for antibacterial drug development; 2) the T6SS machinery can be used as a novel toxin delivery platform to combat multi-drug resistant bacterial infections, using polymorphic MIX-effectors.In this proposal, I will focus on T6SS MIX-effectors and elucidate their activities, mechanism of secretion, and utilization as antibacterial agents, by combining microbiology, molecular biology, genetic, biochemical, and proteomic approaches. Specifically, the goal of this proposal is to utilize T6SSs and MIX-effectors to develop a novel T6SS-based, antibacterial therapeutic platform in which a nonpathogenic bacterium will be engineered to carry a T6SS that can secrete a diverse repertoire of polymorphic antiba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Graph Theory: Colourings, flows, and decompositions' (GRACOL), addressing dissemination and exploitation.

assistant: **Impact**

Graph theory is a relatively new branch of mathematics. Early sources of inspiration are Kirchhoff’s theory of electrical networks and the 4-color problem, both from the 19th century. In the 20th century graph theory was one of the most rapidly growing branches of mathematics with applications to theoretical computer science (design and analysis of algorithms), operations research (combinatorial optimization) and models in engineering and economics. The internet may be thought as a graph. There are also strong ties to geometry, topology, probability theory and logic.The main subjects in the project are graphs in the plane and on higher surfaces, graph decomposition, the Tutte polynomial and the graph flow conjectures, and also combinatorial problems arising from differential geometry. The project is centered around applying new approaches to some classical problems in graph theory, in particular problems in chromatic graph theory and flow theory. In some sense these problems have an algebraic unification in the Tutte polynomial of two variables. The Tutte polynomial has as special valuations (fixing one of the variables) the chromatic polynomial (introduced in 1912 by Birkhoff) and the flow polynomial. More recently, the Tutte polynomial has also become of interest in statistical mechanics.Among the specific problems to be investigated is Tutte’s 3-flow conjecture from the early 1970es, the problem if the flow polynomial can have arbitrarily large roots (motivated by Tutte’s 5-flow conjecture), the Merino-Welsh conjecture on the numbers of spanning trees, acyclic orientations and totally cyclic orientations, and Wegner’s conjecture from 1977 about squares of planar cubic graphs. We expect to get significant new insight (but not complete solutions) to the two notoriously
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Light-Induced Spin Switch using Dynamic Organic Species'.

assistant: **Concept**

The LIDOS project uses in-silico approaches to design nanometer sized photomagnetic (PM) switches. Switches of this kind find use in myriad technological devices, primarily because of their ability to alter their magnetic response upon light irradiation. This project follows an underexplored, yet promising, strategy to obtain new PM switches with enhanced properties. Specifically, dyads (i.e. two-component molecules) will be designed that combine a photoswitch and a magnetic moiety hosting unpaired electrons. Despite attempts to design PM switches employing both transition metals and purely-organic radicals as magnetic units, significant advances in magnetic response remain elusive.This project aims to rationally develop efficient PM switches featuring pronounced changes in magnetic response at room temperature, using purely-organic components. Azobenzene and Diarylethene derivatives will serve as photoswitches, whose primary mission is undergoing a reversible structural change that modulates the magnetic interaction between the radical moieties of adjacent dyads. Thus, the design principles are based on supramolecular choreography. DTA- and Verdazyl- molecules will be targeted as radicals, and will be affixed to photoswitches via linker groups. In the first step, computational screening will be used to explore the best component combinations leading to a set of potential PM switches. In the second step, candidates will be further tuned to optimize their optical properties. The overarching goal is the identification of a reversible PM switch triggered by visible light. LIDOS lies at the intersection of photochemistry, molecular magnetism, computational chemistry, and physical organic chemistry. It combines well-established DFT-based approaches, computational methods to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Climate adaptation in Arabidopsis thaliana through evolution of transcription regulation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Differences in gene expression play a key role in generating the phenotypic variability needed for adaptation. During evolution, the coding sequence of genes evolves on average much slower than their expression patterns, thus transcriptional regulation can be especially important for rapid adaptation to new environments. Climate is a major factor for plant adaptation, and both the dispersal of a plant from its native origin as well as climate change will often lower its fitness. Thus, understanding how gene expression patterns are modified to facilitate life in adverse climates would shed light on the trade-offs limiting adaptation. Studying how evolution has shaped plant transcriptomes so that these plants can grow in different ecological niches and their potential to adapt to a changing climate requires a large base of natural variability information. This has recently been accumulated for Arabidopsis thaliana, a model for genetic and evolutionary studies. In the proposed project I will use genomic and transcriptomic data from the A. thaliana 1001 Genomes Project, new measurements of gene expression under water deprivation, as well as newly available data on gene-regulation and field fitness, to define how gene expression is shaped by climate and the genetic potential to adapt to new environments. I will address the following: (1) In natural populations, how do gene expression patterns of individuals correspond to the particular adapted climates? (2) What is the genetic basis for the transcript differences and how is it reflected in modifications to the transcriptional network? (3) Can knowledge of climate-transcript variation relationships be predictive of individual strains more likely to survive in a new climate? As climate is changing due to global warming, the un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Visual genetics: establishment of a new discipline to visualize neuronal nuclear functions in real-time in intact nervous system by 4D Raman spectroscopy'.

assistant: **Concept**

Due to technical constraints the observation and analysis of endogenous transcriptional processes in living and functioning organisms is not feasible today. Therefore our understanding of the nuclear processes and the options to diagnose or intervene at genetic level is seriously constrained. Our proposal offers a cutting-edge technique to overcome this limitation. The aim is to visualize nuclear processes in intact brain in real-time leading to a new high-tech product development, prototype scientific equipment at the research institutes and in the long run new tools to study and cure human diseases. The main objectives are to: 1) develop Stimulated Raman Spectroscopy (SRS)-based technologies to visualize endogenous transcription at single cell and single locus gene level; 2) develop tools for loading alkyne-tagged nucleosides and nucleotide analogues into cells; 3) distinguish various cells including neuron types without labelling by SRS; 4) track transcription processes in intact cells with high temporal and spatial resolution; 5) develop and commercialise a 4D-SRS microscope for broad range of applications. The combination of label-free neuron mapping and visualization of nuclear activity at single locus gene level provides a new level of information of the structural and functional organization of the organism.The genetic basis of most of the diseases is still unknown. Widening genetic knowledge of diseases will offer as yet unknown therapeutic possibilities. Understanding the neural processes at the genetic level offer the possibility to intervene at that deep level, targeting not only the symptoms but the cause. The proposed novel technology provides new insight to understand for example neural networks and is a key to understand and treat for example nervous sys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Improvement of crash compatibility between cars'.

assistant: **Concept**

The project will provide the start of a scientific approach to the question of crash compatibility between cars. Effort will be concentrated on the most important impact types: car to car frontal and side impacts. Consideration will also be given to the implications for pedestrian and other types of impact.The work will cover three main activities:1. Data from in-depth accident studies will be used to identify the most important problems related to compatibility.2. Typical accident configurations will be replicated by carrying out experimental car to car impacts. These crash tests should help to identify the major problems occurring when two cars impact.3. Computer simulation modelling will be used to study the effects of changing the effective stiffness and mass of two cars impacting. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing the research potential of Institute of Chemistry at Tallinn University of Technology, Estonia' (IC-UP2) targeting Seventh Framework.

assistant: **Abstract**

The objective of the current proposal is to develop the research potential of Institute of Chemistry at Tallinn University of Technology, Estonia.  To achive the general objectives of the proposal, the following activities are foreseen: - stengthening partnerships and establishing new networks with the leading competence centres on the edge of bio-, materials and ICT sciences in Europe; - mobilizing human resources to reinforce competence base in interdisciplinary biochemical and material research; - drawing industry´s and other public attention and recognition to a researcher´s role and contribution to the society through an international conference; - upgrading of research infrastructure; - initation of pan-European joint research projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Interplay Between the Upward Trend in Home-Ownership and Income Inequality in Advanced Welfare Democracies'.

assistant: **Innovation**

This research project is the first comprehensive interdisciplinary study into the so far unrecognised interplay between two major social trends of the post-war period: the upward trend in income inequality, and the increase of owner-occupation. Using a comparative perspective, the project aims at constructing a unified account by means of a systematic analysis of: 1) the ‘driving’ forces of both social trends; 2) the ways in which the upswing in income inequality and the expansion of home-ownership might reinforce or counteract each other and hence lead to a redistribution of social and economic risks; 3) how the statistical relationships between variables at the macro-level play out in diverse institutional settings, looking through a more in-depth historical-comparative lens; 4) how the macro-level relationships between both social trends are negotiated by households and individuals as their housing, labour market and family trajectories unfold; 5) how households and individuals negotiate between their perceptions of the economic benefits and risks associated with home-ownership and the ‘real-life’-opportunities and constraints; and 6) how these norms have changed over time as a result of increased income inequality and/or increasing home-ownership rates.Answers will be provided by means of an innovative multi-method and cross-nationally comparative research design. In four subprojects, I will look at these issues through various lenses, using diverse methods of analysis. I take a longitudinal-historical approach, focussing on the post-war era. My scope ranges from large-scale quantitative analysis of country-level data and of individual retrospective and prospective housing, labour and family trajectories to a comparative in-depth case study of institutional developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Uncovering metabolic cycles in mammals and dissecting their interplay with circadian clocks' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The physiology and behavior of mammals are subject to daily oscillations that are driven by an endogenous circadian clock. The mammalian circadian timing system is composed of a central pacemaker in the brain that is entrained by daily light-dark cycles and in turn synchronizes subsidiary oscillators in virtually all cells of the body. The core clock molecular circuitry is based on interlocked negative transcription-translation feedback loops that generate daily oscillations of gene expression in cultured cells and living animals.Circadian clocks play a major role in orchestrating daily metabolism and their disruption can lead to metabolic diseases such as diabetes and obesity. Concomitantly, circadian clocks are tightly coupled to cellular metabolism and respond to feeding cycles. The molecular mechanisms through which metabolism regulates clocks’ function are just starting to emerge. Recent work of ours and others revealed that NAD+/NADH are implicated in the function of circadian clocks, yet the molecular mechanisms involved are largely unknown. We propose to intensively study the role of NAD+/NADH in the function of circadian clocks and to reveal the underlying mechanisms.The functional interplay between circadian clocks and metabolism raises the question whether there are daily cycles in cellular metabolism and intracellular metabolites. Hitherto, direct measurements of daily changes in cellular metabolism and intracellular metabolite levels are still in their infancy. Our overarching goal is to identify metabolic cycles in mammals and mechanistically address their interplay with circadian clocks. We will monitor metabolic outputs in intact cells and living animals and systemically measure daily changes in intracellular metabolites. Our findings are expected to pus