RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Reconciling Biodiversity and Development through Direct Payments for Conservation'.

assistant: **Innovation**

This project will help to meet the vital need for empirical research into the theory and practice of Payments for Environmental Services (PES). PES approaches to conservation have become rapidly more popular in the last few years, driven by compelling evidence of their effectiveness compared with indirect approaches to financing conservation. This research will exploit a current opportunity to build robust research protocols into the initial design of a PES scheme, thus allowing credible research into its outcomes. This will be undertaken through work with selected communities around the Nyungwe National Park in Rwanda. Communities will be offered cash transfers, contingent on their performance in relation to a set of conservation indicators. One of the great advantages of this project location is the availability of high quality ranger monitoring that, for example, provides regular geo-referenced data on the location of snares, tree-felling and other illicit activities. The outcomes of this experiment will be investigated through interdisciplinary research based on four main types of data. Firstly, data on forest user behaviour, based on the ranger data and additional transect studies; secondly, livelihood surveys that build an understanding of relationships between communities and park resources; thirdly, qualitative data, based on interviews and focus groups, to build an understanding of the social dynamics arising from introduction of the PES scheme; fourthly, public goods games to elicit data on attitudes towards the Park. The research findings will be of use to a wide range of African and international agencies with an interest in better understanding ways of reconciling biodiversity conservation and poverty alleviation. The results will provide a timely input to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The interplay between the appetitive dopaminergic and the aversive serotonergic system in motivational control of behavior' (PHARMACO-FMRI) targeting Seventh Framework.

assistant: **Abstract**

The impact of reward and punishment on behavior is modulated by the neurotransmitters (chemicals that influence signal transfer between neurons) dopamine (DA) and serotonin (5-HT). This project tests a new model of the interplay between DA and 5-HT in motivational control of behavior, by studying the effects of DA and 5-HT increasing drugs on motivational learning and brain activation. Blood oxygen level dependent functional Magnetic Resonance Imaging (BOLD fMRI), a method often used to measure brain activity, is not adequate to assess drug-induced changes in brain activity. In this project new and promising fMRI techniques are used: arterial spin labeling (ASL) and calibrated BOLD fMRI. The results of this project are important for improving methodology in pharmacological fMRI research and may lead to improved treatment for psychiatric patients. The applicant will work for two years (outgoing phase) at the Center for Functional MRI, University of California, San Diego (UCSD), USA. Dr. T. Liu and his colleagues are world leading in the use and development of the abovementioned advanced fMRI techniques. Prof. M. Paulus of the Department of Psychiatry, UCSD, will collaborate on this project. During the return phase, the applicant will work at the Department of Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands, which houses experts in the field of psychopharmacology and toxicology of behavior. This collaboration results in a multidisciplinary research team of experts with excellent training records. The applicant has shown the potential to become a senior researcher. This fellowship will provide the applicant with goal-oriented training, the opportunity to develop complementary skills and to build an international network. The fellowship will m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'INDIVIDUAL MOTIVATIONS AND COLLECTIVE RESPONSES TO GIG WORK AMONG MEDICAL DOCTORS' under Horizon Europe.

assistant: **Concept**

MD GIG examines the transition to digital service provision in the public services by exploring the rise of the ""online doctor"" that provide consultations between doctor-patient via app-based mobile phone technology. The aim is to explore digitalization of healthcare from a worker perspective to highlight the preconditions that give rise to gig work in the healthcare sector and explore the potential consequences at different scales. Whereas before all patients had go to a primary care center on appointment during office hours, today patients can have a consult with a doctor on-demand at any time and from anywhere. Medical work's entry into the platform economy, where work is reshaped into ""gigs"" that workers perform where and when they want, is developing parallel to organizational and economic restructuring of the healthcare system towards more marketization and private-public partnerships. The project sets out to understand the individual motivations for doctors to take up work in digital doctor platforms through in-depth interviews to produce narratives based in the MDs own experiences, to explore the approach of the trade unions and medical associations to digital doctor platforms through expert-interviews with high level union employees to document their hopes, fears and strategies regarding changing labour markets and working conditions, and to analyse the role of digital doctor platforms in public healthcare restructuring to produce a political economy of digital healthcare in Europe.""


**Keywords:** Digital service provision,  digital health work,  platform economy,  work organization,  labour and, globalization,  feminist geography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Genome editing of noncoding regions to map sequence-function relationships at scale'.

assistant: **Concept**

Deciphering how genetic variants lead to disease can advance precision diagnostics and mechanistically informed therapies. Yet, our ability to link variants in the human genome’s vast noncoding regions to phenotypic consequences is highly limited. This stems largely from a lack of experimental evidence on individual variants’ functional effects. Here, we propose to develop and deploy a suite of new genome editing methods to generate functional data for noncoding variants at unprecedented scale.First, we will leverage a prime editing screening platform we have recently established to systematically ask how intronic variants and 5’-untranslated region (5’UTR) variants lead to loss of function (LoF) across dozens of human disease genes. Second, we will interrogate relationships between regulatory sequence variants, transcription factor binding sites (TFBSs), and genomic contexts across diverse cell types using novel methods to link variants to effects on messenger RNA (mRNA) levels. Third, we will uncover new noncoding variants underlying disease by combining variant effect prediction with large-scale functional assessment.Collectively, this work will establish new technologies to experimentally characterize noncoding variants, delineate sequence-function relationships from 100,000s of variant effect measurements, and substantially advance our ability to predict, identify, and engineer noncoding variants of functional importance.


**Keywords:** functional genomics, human genetics, multiplexed assays of variant effect (MAVEs), rare disease, cancer genetics, noncoding variants, splicing, gene regulation, sequence-function models, prime editing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TRAVEL HEALTH INFORMATION NETWORK' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

This project is concerned with travel medicine, and targets travellers from Europe. It aims to contribute to the protection of people's health both in Europe and abroad, in view of the increasing threat of newly emerging diseases arriving into Europe. It intends to create a database of reliable information on travel health, matched to the needs of the traveller and the travel industry, which can be transmitted electronically. The project will ensure that the information is appropriately formatted and managed through a well-defined infrastructure; that it is brief, simple and automatically included on materials routinely provided by travel agents to their clients. Information will include major health risks for any chosen travel destination, and will be multilingual, for use across Europe and other continent. Where necessary, it will advise clients to visit their general practitioner or local travel clinic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhancing the innovation management capacity of SMEs through the Enterprise Europe Network in Macedonia (INNO EEN-M)' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The general objective of the INNO EEN-M project is to increase the economic returns from innovation and enhanced innovation management capacities of the Macedonian SMEs through offering a standardised set of coaching and innovation management services. The project aims to deliver 26 (twenty-six) 7-day service packages: 20 package services will be provided to SMEs with significant innovation activities and high potential for internationalization and 6 packages for the SME instrument beneficiaries. As the national consortium is responsible for providing services at whole territory of the country, this project will also cover the same area. The services will be delivered by three innovation experts/Key Account Managers (KAM) from UKIM, member of EEN Macedonia. The INNO EEN-M project is highly related to the call for Enterprise Europe Network – Horizon 2020 (2017-2018) and will provide necessary tools, knowledge and experience to the EEN-M for implementation of the specific activities in the context of innovation support. The activities within the project are organized in two work packages: key account management (KAM) for the beneficiaries of the SME instrument and enhancing SME innovation management capacities for innovating SME independently from a specific project. The selection of SMEs will be done based on identified criteria whereas services will be delivered in line with the specific common format with the packages. The team will use the IMP³rove tool as an assessment tool. The KAM will undertake needs analysis/coachcom tool to support SMEs in selection of lead coach. The planned duration of both work packages is 24 months (2017-2018). The services, benefits and experiences from these activities will be part of internal evaluation. The beneficiaries of these activit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Holistic digital-to-physical prototyping and production pilot for microfluidic MEMS' (HoliFAB), addressing dissemination and exploitation.

assistant: **Impact**

The project aims at a holistic new design strategy, coordinated pilot lines and business model for the prototyping, fabrication and commercialization of polymer-based microfluidic systems.  It stems from the recognition that a microfluidic chip is a key part of a microfluidic MEMS, but only a part. Many limitations to fast prototyping, industrialization and ultimate performances lie not in the chip itself, but in the world-to-chip connections and integration of multiple external components. We shall address in a single strategy the streamlined construction of whole microfluidic systems, starting from existing pilot lines in injection moulding, 3D printing and instrument construction. This will specific innovations. First, the resolution of 3D printing will be increased by a factor at least 10, down to  1~3µm, with a throughput 10 to 100x higher than that of current high resolution 3D printing machines, to support the flexible production of chips with complex 3D architectures. New soft, bio, environment-friendly and/or active materials will be integrated in the production chain using a technology patented by the partners. Large-scale markets requiring mass production at the lowest cost  will be addressed by a fully integrated pilot line, streamlining injection moulding of raw chips, reagents and components integration, sealing  and quality control.  Inter-compatibility between 3D printing and injection moulding, regarding architectures  and materials, will be developed to accelerate the prototype to product value chain.  After development and upscaling, the technology will be demonstrated and qualified in operational environment  by end-users with lab-on-chip  applications in health (cancer diagnosis, organ-on chip) and environment (water control). Partners jointly have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Efficacy of Leveraging Endocrine Therapies for Renoprotection during Intensive Care' to be submitted under Horizon 2020.

assistant: **Abstract**

On the intensive care unit, more than 50% of patients have acute kidney injury, and these patients suffer higher mortality and long-term morbidity. To date, no specific therapies exist to prevent or treat acute kidney injury on the intensive care unit. We now have two new endocrinologic agents, glucagon-like peptide-1 receptor agonists and sodium-glucose transport protein 2 inhibitors, able to protect patients with diabetes from chronic kidney disease. The objective of this action is to investigate whether the renoprotective mechanisms of these agents can reduce markers of acute kidney injury in patients on the intensive care unit. This action incorporates a highly sophisticated animal model for the essential invasive measurement of renal physiology. To translate these findings to the clinical situation, I will employ new and innovative measurement techniques such as urinary oxygenation, new kidney biomarkers and advanced renal imaging techniques to elucidate these renoprotective mechanisms in humans. The involved universities of Amsterdam and the University of Melbourne bring together world leading experts on acute kidney injury, endocrinologic therapies, and intensive care medicine. By connecting their expertise, this action will not only provide insight into the renoprotective properties of the studied interventions and so improve the outcome of patients, but also train me as a researcher able to improve renal outcomes beyond the scope of this action.


**Keywords:** Intensive Care Medicine, Nephrology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An Ecosystem of Citizen Observatories for Environmental Monitoring' to be submitted under Horizon 2020.

assistant: **Abstract**

The rising trend in citizen science has led to the development of Citizen Observatories (COs) for environmental monitoring, which have been supported in FP7 and H2020. To improve the coordination between existing COs and related regional, European and international activities, the WeObserve Coordination and Support Action will tackle three key challenges that face COs: awareness, acceptability and sustainability. The WeObserve mission is to create a sustainable ecosystem of COs that can systematically address these identified challenges and help move citizen science into the mainstream. The WeObserve approach will apply several key instruments to target, connect and coordinate relevant stakeholders. The first is to develop and foster five communities of practice to strengthen the current knowledge base surrounding COs. Topics will include citizen engagement, the value of COs for governance and CO data interoperability. In co-creating this knowledge base, CO practitioners will have a platform to effectively share best practices and avoid duplication. The second will expand the geographical reach of the knowledge base to different target groups via toolkits, a Massive Open Online Course, capacity development roadshows and an Open Data Exploitation Challenge, to strengthen the uptake of CO-powered science by public authorities and SMEs. A third mechanism will forge links with GEOSS and Copernicus to demonstrate how COs can complement the EU’s Earth Observation monitoring framework. The WeObserve consortium brings together the current H2020 COs (Ground Truth 2.0, GROW, LandSense, Scent) who will actively open up the CO landscape through wide ranging networks, users and stakeholders, including ECSA, GEOSS and Copernicus to foster social innovation opportunities. The WeObserv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of shared micromobility modes in the resilience of urban transportation systems: New challenges and opportunities' (ROMSUR), addressing dissemination and exploitation.

assistant: **Impact**

Increasing urban traffic and environmental challenges have driven the investigation, development, and diversification of sustainable transportation alternatives globally. The resilience of these alternatives has also been considered equally important in recent research in order to ensure a more safe, accessible, and equitable transportation system during severe disruptions. However, there is a lack of comprehensive evaluation system through which urban and transportation planners can assess and plan for transport resilience in their own geographical contexts. In this regard, this research proposes a model to evaluate an overall resilience of shared micromobillity systems through their commonly available usage patterns in light of current challenges and future opportunities. Specifically, it takes major shared micromobillity programs (e.g., station-based bike-sharing (SBBS), free-floating bike-sharing (FFBS), free-floating e-bike sharing (FFEBS), and free-floating e-scooter sharing (FFESS)) operating in Europe as examples to empirically analyze the mobility patterns of their users across three timescales: before, during, and after the pandemic. As a methodology, this study will utilize a combination of quantitative and qualitative techniques. The expected outcomes will help in improving governance and an appropriate appraisal of sustainable urban transport alternatives, which are still in its infancy. The resilience assessment tool will further help develop long-term systems for measuring and executing mobility plans on both sides of the mobility equation: supply and demand.


**Keywords:** Shared micromobility,  Transport resilience,  Mobility as a Service,  Urban Sustainable,  Active mobility,  COVID-19,  Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'miR-483-3p and drug resistance in Hepatocarcinoma' (VEROMIRNA) under Seventh Framework.

assistant: **Objectives**

Hsa-mir-483 is located within intron 2 of the INS-IGF2 gene. We have previously shown oncogenic features of miR-483-3p targeting the pro-apoptotic gene BBC3/PUMA (P53 up-regulated modulator of apoptosis gene) giving drug resistance to cells. Generally the IGF2 and miR-483 expression are strictly correlated although we have demonstrated that expression of miR-483 can be induced independently of IGF2 by the oncoprotein b-catenin. In Hepatocarcinoma (HCC) IGF2/483 locus is often over-expressed probably by Loss of Imprinting (LOI) at the IGF2/H19 imprinted control region (ICR) and HepG2 and Hep3B HCC cell lines shown the entire IGF2/483 locus up-regulated. As a matter of fact we found that the treatment with the de-methylating agent 5-azacytidine, induces an important down-regulation of IGF2 and miR-483-3p genes.Moreover, during the course of our study we found that the chemotherapeutic drug 5-fluoruracyl (5-FU) induces increased expression of miR-483-3p in HepG2 and Hep3B cells. 5-FU treatment does not affect all the HCC cell lines that we tested suggesting a possible heterogeneity in cellular drug resistance dependently from miR-483-3p induced expression. Aim of this project is to investigate the mechanism involved in the 5-FU/miR-483 regulation, identify its importance in chemotherapeutic resistance in HCC primary tissues and explore if a concomitant treatment with the de-methylating agent 5-azacytidine and chemotherapeutic 5-FU, could improve the susceptibility to apoptosis of cancer cells.