RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Linking Synchronic and Diachronic Analysis of Paradigms' (LSDAP).

assistant: **Innovation**

Speakers of even highly irregular inflecting languages can usually produce all forms of all lexemes (e.g. do, does, did). How they can do so on the evidence of skewed and partial input is known as the Paradigm Cell Filling Problem. The increased availability of large inflected lexicons, and computing power and tools to assess cell-to-cell predictive uncertainty have enabled us in recent years to automatically measure multiple aspects of paradigm complexity and structural similarity. Unfortunately, this quantitative turn in morphology has been almost entirely limited to synchronic analyses. This project seeks to harness the power of novel quantitative methods (e.g. Information and Set Theory, Bayesian models) for the study of paradigmatic change as well. The focus will be on Romance verbs, as the most historically documented and best-understood inflectional system worldwide.Regarding synchronic variability, I will integrate the best and largest extant inflected lexicons in the family (5000+ complete verbs for the 5 largest Romance languages and Latin). All forms will be annotated for lemma-level and cell-level cognacy to produce a reusable and expandable pan-Romance etymological inflected lexicon. Turning to diachrony, one of the greatest obstacles to analyzing morphological change is distinguishing it from regular sound change. Given the large number of words and changes it is impossible to derive an optimal chronology of sound changes by hand. I will therefore write software that applies sets of ordered sound changes automatically to large inflected lexicons (e.g. of Latin) to derive expected forms. Comparing these to actual forms will reveal where morphological changes have occurred historically and enable us to explore what the best predictors are of analogical chang
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From bond breaking to material failure in soft polymer networks' (SOFTBREAK), addressing dissemination and exploitation.

assistant: **Impact**

The microscopic mechanisms that lead to mechanical failure of soft polymer materials are still poorly understood. The main reason for this is a lack of experimental tools to prepare well-controlled model systems and to observe the failure process in real time at the microscopic scale. Here, I propose to fill this gap by taking a multidisciplinary approach that combines innovative chemical tools with state-of-the art physical experiments and modelling. Previous work in my group has led to the development of polymer networks with extremely well-controlled architecture and bond strength, and of various tools to study their structure and mechanics. Here, I will take advantage of this expertise to systematically unravel the microscopic physics of failure of polymer networks. To visualize how the failure process proceeds, we will make use of recently developed mechanosensors, molecules that change colour in response to a force or that emit light when they break. These chemical tools will allow us to map in real time the spatial distribution of both strains and bond rupture events. Together with computer simulations carried out in parallel, this will give us unprecedented insight in the microscopic processes that occur during failure of the material, from the very first bonds that rupture, to the gradual accumulation of damage, all the way to macroscopic failure. We will use this to address the following unresolved questions about failure of polymer networks:1. What is the microscopic mechanism that leads to delayed failure of polymer networks at subcritical loads? 2. How does the initiation of failure depend on the material's heterogeneity? 3. How does failure occur in a network with transient (viscoelastic) bonds?The project will not only provide detailed insight in the phys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stochastic Laplacian Growth' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Recent breakthrough in the theory of 2D growth, due to application of analytic theory of stochastic conformal mappings, opened new prospectives for solution of fundamental long-standing problems in the studies of interface dynamics and pattern formation. The research field has been enriched by new effective approaches, emerged from theory of integrable systems and analytic function theory, to deal with dynamics of a moving front between two distinct phases driven by a harmonic scalar field as well as for description of static cluster patterns in models of statistical mechanics and random matrices. The aim of the present project is to address the basic questions of theory of unstable and stochastic interfaces, integrating recent achievements in stochastic conformal mappings and complex dynamics into the field of research. Connecting three subjects: Laplacian growth, stochastic Loewner chains and theory of integrable systems, we expect to advance interface dynamics and account for its basic physical features.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Light weight, impact resistant, canopy for fast compound rotorcraft'.

assistant: **Innovation**

Design and manufacturing of an economical lightweight, safe and flight worthy canopy structure optimised for low aerodynamic drag, best field of view and in accordance with CS 29 requirements regarding bird strike capabilities for the high speed LifeRCraft.Low weight design is intrinsically assured through the application of the innovative one-shot design of the canopy as a hollow single piece CFRP structure. The chosen tooling concept allows the manufacturing of the prototype as well as a low series production. Know how transfer from the automotive sector, mainly motorsport, is assured. The applicants have an excellent record in maintaining even the tightest schedules and delivering highest quality products on time and on budget.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Eliminating onchocerciasis with Moxidectin in endemic hotspots of Central Africa', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Onchocerciasis is a neglected tropical disease leading to blindness and associated with epilepsy. Most cases are in sub-Saharan Africa. The WHO has proposed that its transmission be interrupted in a third of endemic countries by 2030. The main strategy is annual Community-Directed Treatment with Ivermectin (CDTI). Despite nearly 3 decades of CDTI, transmission persists in several foci. In Phase II & III clinical trials, moxidectin has shown superior efficacy compared to ivermectin, clearing Onchocerca volvulus microfilariae for nearly a year. No large-scale community trials have yet been undertaken to document its effectiveness and safety for mass treatment. A barrier to onchocerciasis elimination is its co-endemicity with loiasis in Central Africa. Individuals with high Loa loa microfilaraemia may develop serious adverse events if treated with ivermectin. EMINENCE will address these challenges through: 1) a Phase IIIb community trial of annual or biannual moxidectin compared to annual ivermectin in Bafia and Monatele, Cameroon, renowned for their high transmission intensity, 2) a Phase II adaptive trial of ascending moxidectin doses on increasing L. loa microfilarial densities, and 3) a social sciences study to assess the acceptability of and adherence to moxidectin. We will evaluate and model the epidemiological impact of annual or biannual moxidectin compared to annual ivermectin through parasitological, serological and entomological surveys, and will attempt to elucidate potential differences between the two drugs regarding their effects on adult worms. We will evaluate the safety, tolerability and efficacy of moxidectin compared to ivermectin in L. loa-infected individuals in the Republic of Congo and Cameroon. Our project will contribute to the evidence-base that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Audio Bracelet for Blind Interaction: a new technology based on sensory-motor rehabilitation for visually impaired children' to be submitted under Seventh Framework.

assistant: **Abstract**

The problemThe development of technologies to support the inclusion of adults and children with visual disabilities is a big societal challenges for ICT Research. Vision is essential to build up important cognitive representations and early onset of blindness affects adversely psychomotor, spatial and social development. Moreover, early intervention is fundamental.ObjectivesThe ABBI project aims at: Developing a new set of devices to rehabilitate spatial cognition, mobility and social interaction of children and adults with visual deficits through natural audio-motor and tactile-motor associations, demonstrating and validating the technology through user, experimental and clinical studies.The core idea of the project, based on a new understanding of the role of vision in the development of blind and normal children, is that audio feedback about body movements might help the blind child to build a sense of space. The main device to achieve this objective is the Audio Bracelet for Blind Interactions (ABBI) which will be positioned on the wrist of the child and/or of the people around. The generated sound (for which the position will be perceived aurally) will be triggered by the body movement and will give spatial information on where and how the movement is occurring. The use of ABBI will provide important information for posture control, motor coordination and spatial orientation reducing the risk of exclusion for disabled individuals.Why it is innovativeUnlike most existing sensory substitution devices that are introduced in late childhood or adulthood, the approach proposed in ABBI does not require to learn new languages" and it can be applied in the first years of life. Further development of the ABBI in this project will endow the device with the capacity to inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Characterization of conditioned nuclear waste for its safe disposal in Europe'.

assistant: **Objectives**

Successful interim storage and final disposal of radioactive waste (RW) requires effective characterization and quality control of the waste. CHANCE aims to address the as yet unsolved and specific issue of the characterization of conditioned radioactive waste (CRW).CHANCE will establish a comprehensive understanding of current characterization methods and quality control schemes for conditioned radioactive waste in Europe. Furthermore, CHANCE will develop, test and validate already-identified and novel new techniques that will undoubtedly improve the characterization of CRW.Input from “end users” (mainly WMOs and waste producers) on methods of CRW characterization is critical to the success of CHANCE. Therefore, a dedicated End-Users Group will be established within CHANCE in order to represent and promote the interests and requirements of end-users.One of the project’s key tasks will be dedicated to the identification of links and overlaps between waste acceptance criteria and actual waste characterization technologies available, in order to identify specific, as yet unsolved, methodology issues and technology gaps. CHANCE’s R&D programme consists of the testing and evaluation of the performance of 3 innovative characterization techniques that are complementary and supplementary to current techniques for the non-destructive assay of RW, specifically:• Calorimetry as an innovative non-destructive technique to reduce uncertainties on the inventory of radionuclides (RN), namely from hidden RN-compounds with a weak gamma signal.• Muon Tomography to address the specific issue of the non-destructive interrogation of the content of large volume RW.• Cavity Ring-Down Spectroscopy as an innovative technique to characterize outgassing of RW at a very low detection level.The act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'How MHC-I editing complexes shape the hierarchical immune response' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Our body constantly encounters pathogens or malignant transformation. Consequently, the adaptive immune system is in place to eliminate infected or cancerous cells. Specific immune reactions are triggered by selected peptide epitopes presented on major histocompatibility complex class I (MHC-I) molecules, which are scanned by cytotoxic T lymphocytes.Intracellular transport, loading, and editing of antigenic peptides onto MHC-I are coordinated by a highly dynamic multisubunit peptide-loading complex (PLC) in the ER membrane. This multitasking machinery orchestrates the translocation of proteasomal degradation products into the ER as well as the loading and proofreading of MHC-I molecules.Sampling of myriads of different peptide/MHC-I allomorphs requires a precisely coordinated quality control network in a single macromolecular assembly, including the transporter associated with antigen processing TAP1/2, the MHC-I heterodimer, the oxidoreductase ERp57, and the ER chaperones tapasin and calreticulin. Proofreading by MHC-I editing complexes guarantees that only very stable peptide/MHC-I complexes are released to the cell surface.This proposal aims to gain a holistic understanding of the PLC and MHC-I proofreading complexes, which are essential for cellular immunity. We strive to elucidate the mechanistic basis of the antigen translocation complex TAP as well as the MHC-I chaperone complexes within the PLC. This high-risk/high-gain project will define the inner working of the PLC, which constitutes the central machinery of immune surveillance in health and diseases. The results will provide detailed insights into the architecture and dynamics of the PLC and will ultimately pave the way for unraveling general principles of intracellular membrane-embedded multiprotein assembl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ceramic cutting tools for woodworking applications' to be submitted under Fourth Framework.

assistant: **Abstract**

The cutting of wood and wooden materials is challenging technologically, and isalso important because of the size of the market. The woodworking industry isan important factor in Europe. For example, a turnover of more than DM 75billion was earned in 1994 with 328,159 employees in this area in Germanyalone. 95% of these woodworking operations employ fewer than 500 persons. Thestructures are comparable in other EC states. In the first phase, cutting data should be collected and processed for the different wooden materials. They willbe used for the definition of the concept and to dimension the first testtools. Promising ceramic cutting materials will be tested under realisticconditions. In parallel, various models will be tested for their practicabilitywith FEM support. The calculational models to be developed will describe loads for the specific material in the operation as well as the bonding stressesresulting through the combination of materials. Material connections as well asstrength connections will be evaluated thereby. The objective here is todevelop the principles of solutions for the integration of high quality ceramiccomponents. The combination tools will be tested for their long-term stability and resistance to wear. In addition, the adaption work necessary for apractical test will be performed. In the planned field tests, the modules must,for example, produce evidence that they will permit longer service lives and animprovement in the quality of the goods to be produced. In parallel,specially-designed model tests should test the suitability of different ceramiccutting materials for a wide range of workpiece materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Martí i Franquès Doctoral Programme Plus' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The Rovira i Virgili University (URV) is well positioned nationally and internationally due to the Excellence of its research and the commitment and internationally recognised staff. URV welcomes annually 11.200 undergraduate, 1.300 masters and 1.200 PhD students. In 2018, it was named World’s 78th Best Young University aged less than 50 years (by THE World University Rankings). At Spanish level, in 2017, URV was the 4th in publications by permanent teaching staff and 7th with Highly Cited Papers per each 100 permanent teaching staff. The URV endorsed the Charter and Code in 2008, obtaining, in April 2014, the HR Exellence in Research award by the EC, renewed in 2017. URV offers doctoral studies distributed in 24 programs in all areas of knowledge, and state of the art facilities in which the fellows can develop their research projects.The URV was granted (and running with great success) a first MSCA-COFUND-DP in 2015 for the implementation of a programme of 50 doctoral positions, with a total value of 8 M€ (4 M€ funded by the EC). With this new COFUND project (MFP Plus), we will offer 50 PhD Positions in two calls (in 2020 and 2021), and we will expand on some critical aspects, the backbone of the doctoral education: diversity to foster innovation (thanks to the explicit support of 59 partner organisations, 21 of which are non-academic); better pportunities for candidates in difficulties; integration with the intelligent specialisation of the region, and improved training and support for the doctoral candidates.Our MFP Plus meets all the necessary conditions to be the catalyst of a larger change in our university and region, starting the process of improving employment and working conditions for all the researchers and creating a real impact of our research and on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A deep learning-derived, shear wave elastography biomarker for cancer therapy prediction' (DL-ElastoMark) under Horizon Europe.

assistant: **Objectives**

The efficacy of standard cancer therapies varies, and while some patients respond to a particular treatment, other patients do not gain any benefit. In response, an era of individualized cancer treatments is emerging which are based on the identification of biomarkers that characterize the state of a tumor. Many solid tumors (e.g., breast cancers and sarcomas) stiffen as they grow within a normal tissue. Tumor stiffening is a known factor leading to compromised efficacy of therapeutics. Repurposing drugs in order to alleviate tumor stiffness before the initiation of therapy has been tested in preclinical studies and has recently made it to the clinic. Despite recent success of these strategies, optimization of their application is understudied. Here, we aim to harness the power of deep learning (DL) methods in order to construct a robust biomarker based on ultrasound shear wave elastography (SWE). The biomarker will aim to: (i) predict the tumors response to treatment with chemo- and immuno-therapy and (ii) monitor treatment outcomes, in the case of strategies that target tumor stiffness. The project will capitalize on the existing strengths of the applicant in medical image processing and DL and the expertise of the host in tumor mechanopathology and in vivo experiments. In past experiments, the host acquired a large number of SWE tumor data, which will enable the development of the DL biomarker. Through the experimental part of the project, additional data on murine cancer models will be acquired enabling the validation of the biomarker. Formulation of the developed DL-derived biomarker in a user-friendly software will allow for potential clinical translation and further exploitation through IPR. The applicant will acquire new knowledge in the fields of cancer therapy