RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European drag reduction network' (1994-1998).

assistant: **Concept**

The development of aerodynamic drag reduction technologies is driven by predictions of remarkable fuel savings, promising substantial improvements not only of aircraft efficiency but also of environmental compatibility. The European Community has supported research and technology development in the field of laminar flow and drag reduction RTD from 1989 onwards. In order to generate an added value of this investment, the establishment of an European Drag Reduction Network (DragNet) is proposed.Six contracted EC projects (with 42 partners from 13 countries):- HYLDA - Hybrid Laminar Flow Demonstration on Aircraft;- HYLTEC - Hybrid Laminar Flow Technology;- EUROTRANS - European Program on Transition Prediction;- EUROSHOCK II - Drag Reduction by Shock and Boundary Layer Control;- AEROMEMS - Investigation of the Viability of MEMS Technology for Boundary Layer Control on Aircraft;- EUROSUP - Reduction of Wave and Lift-dependent Drag for Supersonic Transport Aircraft have expressed their willingness to cooperate in the frame of DragNet.This type 1.5 network, proposed for a period of 3 years, will be open not only to further EC projects to be launched later but also to complementary non-EC European and national activities in this field.The primary aim of this network is to maximise the industrial return of European RTD investment in the development of aerodynamic drag reduction technologies, to be achieved by implementation of a flexible network structure in order - to extend the communication between the European experts involved in drag reduction RTD - to focus the RTD resources spent in Europe for drag reduction technology development - to intensify the information and data exchange between the incorporated RTD teams - to enhance technology and know-how transfer between indus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Plasma epigenomics: A new liquid biopsy paradigm' under Horizon 2020.

assistant: **Concept**

Genomic DNA is packaged by histone proteins that carry a multitude of post-translational modifications, which reflect cellular transcriptional states. When cells die, fragmented chromatin retaining histone modifications is released to the circulation. Recently, we pioneered chromatin immunoprecipitation of cell-free nucleosomes carrying active chromatin marks followed by sequencing (cfChIP-seq). Our results show that cfChIP-seq provides multidimensional epigenetic information and that the plasma epigenome contains rich information about the identity and the transcriptional state of the originating cells. Liquid biopsies already entered the clinical practice, yet current methodologies use them to assess genetic information. Our breakthrough methodology opens an unprecedented opportunity to delineate the transcriptional state of specific cell types and different pathologic states. Here we aim to translate plasma epigenomic information into medically relevant findings. The challenge is recovering the states of the cells represented in the circulation and relate these to pathological processes. Our working hypothesis is that this task is attainable by probabilistic modeling exploiting knowledge about epigenomics and transcription programs in health and disease. In this project we will assay plasma samples from multiple patient and donor cohorts to characterize the relation between tissue gene expression and circulating chromatin profiles, to recover the immune system status and chart how it changes with disease progression and response to treatment, and to monitor transplant patients for early detection of rejection. Our extensive preliminary data, our expertise in probabilistic modeling and genomics and our collaborators’ access to relevant patient cohorts support the proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next-Gen Targeted Protein Degradation: Directing Disease Proteins to the Proteasome' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The ubiquitin-proteasome system (UPS) is crucial for maintaining diverse cellular functions through the selective degradation of proteins. Targeted Protein Degradation (TPD) has emerged as an innovative therapeutic strategy that harnesses the UPS to selectively degrade disease-causing proteins. A major advancement in TPD is the use of proteolysis-targeting chimeras (PROTACs), small molecules that bind both an E3 ligase (E3) and the target protein, to induce ubiquitination and subsequent degradation of the target. While PROTACs have shown promise, their reliance on E3s poses challenges, including tissue-specific expression of E3s, the requirement for accessible ubiquitination sites on target proteins, and potential resistance mechanisms due to E3 mutations. Furthermore, only a small subset of E3s has been successfully utilized for TPD.To address these challenges, this ERC PoC project explores an alternative approach: direct targeting of proteins to the proteasome for degradation, bypassing the need for ubiquitination. This strategy eliminates reliance on specific E3s and provides a broader, universal approach for proteolysis. During our ERC StG project, using cutting-edge proteomics technology, we identified short peptide motifs that when fused to target proteins, can promote their ubiquitin-independent proteasomal degradation (UbInPD). These findings present a novel opportunity to design PROTACs that directly recruit targets to the proteasome, bypassing the traditional limitations of E3-based systems.Here, we aim to develop PROTACs incorporating UbInPD short peptide motifs to enhance TPD of model disease-associated proteins, such as the androgen receptor and BRD proteins, for cancer treatment. This approach could significantly broaden the scope of targetable proteins, o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Graph theory and general topology: foundations, infinite graphs and beyond' (TOPGRAPHS).

assistant: **Innovation**

In spite of the traditional gap between graph theory and topology, it is possible to view a graph as a (possibly finite) non-trivial topological object.With respect to this novel topology, the ground set consists of the vertices and edges of the graph, so that an edge is as much of a 'point' in the space as a vertex is, in contrast with the traditional way of modelling a graph as a one-dimensional cell-complex.This topological construction reduces graph-theoretic connectedness directly to connectedness in the sense of abstract topology, and is the basis for the recent work of Richter and Vella. This work generalizes standard results from graph theory to a certain class of topological spaces, and simplifies and generalizes the related recent work of Dieste l and Kuhn.Since the new perspective translates the notions of graph theory into topological concepts, it brings together the fields of graph theory and point-set topology in a fundamental way, and opens up an array of questions much wider in scope than the issues addressed so far.The objectives of this project are inspired by the potential to bring this new approach to bear on the central tenets of finite and infinite graph theory, including Menger's Theorem and graph minors, and the related field of matroid theory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Global as Artefact:  Understanding the Patterns of Global Political History Through an Anthropology of Knowledge -- The Case of Agriculture in Four Global Systems from the Neolithic to the Present'.

assistant: **Objectives**

Knowledge is an anthropological constant that is indissociable from the birth and interactions of human societies, but is at best a secondary concern for scholars of international relations and globalization. Contemporary global studies are thus unable to account for the co-constitution of knowledge and politics at a macro-scale, and remain especially blind to the historical patterns of epistemic development that operate at the level of the species as a whole and have shaped its global political history in specific, path-dependent ways up to now.ARTEFACT is the first project to pursue a knowledge-centered investigation of global politics. It is uniquely grounded in an anthropological approach that treats globalization and human knowledges beyond their modern manifestations, from the longue-durée perspective of our species’ social history. 'The global as artefact' is more than a metaphor. It reflects the premise that human collectives 'make' the political world not merely through ideas, language, or norms, but primordially through the material infrastructures, solutions, objects, practices, and skills they develop in response to evolving structural challenges. ARTEFACT takes agriculture as an exemplary and especially timely case-study to illuminate the entangled global histories of knowledge and politics, analyzing and comparing four increasingly inclusive 'global political systems' of the Ancient, Medieval, Modern, and Contemporary eras and their associated agrarian socio-epistemic revolutions. ARTEFACT ultimately aims to 1) develop an original theory of the global, 2) launch Global Knowledge Studies as a new cross-disciplinary domain of systematic empirical and theoretical study, and 3) push the respective boundaries of the anthropology of knowledge, global history, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'GaTHeR, Gender and Transfer of Knowledge in Hunter Gatherer Research'.

assistant: **Innovation**

This project analyses feminist knowledge transfer in mainstream Science. Following the European Research Area key priority of strengthening the Gender dimension in research programs, the goal of this research is building a methodology to better understand the relations between Knowledge Production, Gendered Organisations and Methodological Challenges through a multidisciplinary case-study; hunter-gatherer (HG) research. The knowledge acquired on HG is deeply committed to erasing the frontiers between social and natural sciences and shedding light on the history of Humankind. HG studies are essential for understanding Human nature and how androcentrism has shaped specific disciplines and are also a promising field of research for exploring new methodologies (e.g., experimental games or social simulation). The research project examines the nature of knowledge transfer and the barriers preventing feminist knowledge from being integrated into distinct disciplines.The research adopts a mixed method approach. The first part consists of a retrospective discourse analysis offering a cartography of feminists’ contributions based on major scientific publications within HG studies from 1960 to present. The second part is a case study combining both quantitative and qualitative techniques. The quantitative online survey will test the first assumptions and enable to identify a group of participants. Also, 40 semi-structured interviews will be conducted with specialists on HG societies. Key questions concern the structural obstacles related to organisational changes, methodologies, and the frontiers between the disciplines that prevent gender from becoming a transversal issue. This research will address how gendered power relations within Academia normalize epistemology today. Finall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'International Support of a Common Awareness and Knowledge Platform for Studying and Enabling Independent Living'.

assistant: **Innovation**

The aging of society is the single most important aspect of health care in the 21st century. Many intriguing ICT solutions are being developed within the EU, USA, and Japan for helping older people remain independent longer. However, these solutions tend to be fragmented and heterogeneous. The CAPSIL CSA team is a coalition of University and Industrial partners that already have extensive teams developing hardware/software/knowledge solutions to independent living based on established clinical requirements.  All partners of CAPSIL are already members of regional and national centres on aging engaged in the process of helping to establish public policy and international standards. This support action is to launch initiatives, coordinated and disseminated by a series of workshops in the US, EU, and Japan (two per year for two years), with two fundamental goals: <br/>1.\tto develop a detailed CAPSIL Roadmap for EU research to achieve effective and sustainable solutions to independent living based on an in-depth analysis of clinical requirements and the ICT scenarios developed or under development in the EU, as well as the US and Japan (societies where the aging of the population are currently on par or exceeding the challenges that will be found within the EU).<br/>2.\tto support aging research by proposing procedures to incorporate all of these diverse solutions into WiKi entries (CAPSIL WiKi) which describe interoperable ICT solutions to clinical requirements for independent living that can then be deployed throughout the EU, US, and Japan for verification and testing. These CAPSILs will enable clinicians and other care-givers to get the information they need to quickly and easily test solutions for prolonging independent living within the many and various heterogeneous
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'TRPV1-targeted ligand-drug conjugates to treat prostate cancer' (TRPLigDrugConj) targeting Horizon 2020.

assistant: **Abstract**

Cancer remains a leading cause of death and morbidity worldwide. Prostate cancer (PC) is among the most frequently diagnosed non-skin cancers. Despite major advances in the understanding of cancer biology and development of candidate therapeutic agents, there is still an urgent need of exploiting innovative chemotypes and disrupting novel signalling pathways. Evidence suggests that targeted therapies may provide an original means of selectively modulating diseased prostate cells. Herein we propose the validation and devlopment of an unprecedented approach to tackle PC, addressing the overexpressed transient receptor potential vanilloid channel V1 (TRPV1) with ligand-drug conjugates. This strategy provides a pioneering technological advance by aiming at the disruption of calcium signalling, while selectively targeting cancer cells for the delivery of cytotoxic payloads. The approach will additionally yield chemical probes for studying TRPV1 biology and for whole-animal optical imaging of TRPV1-overexpressed cancer cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Catastrophic Interactions of Binary Stars and the Associated Transients' under Horizon 2020.

assistant: **Concept**

One of the crucial formation channels of compact object binaries, including sources of gravitational waves, critically depends on catastrophic binary interactions accompanied by the loss of mass, angular momentum, and energy (""common envelope"" evolution - CEE). Despite its importance, CEE is perhaps the least understood major phase of binary star evolution and progress in this area is urgently needed to interpret observations from the new facilities (gravitational wave detectors, time-domain surveys).Recently, the dynamical phase of the CEE has been associated with a class of transient brightenings exhibiting slow expansion velocities and copious formation of dust and molecules  (red transients - RT). A number of RT features, especially the long timescale of mass loss, challenge the existing CEE paradigm.Motivated by RT, I will use a new variant of magnetohydrodynamics to comprehensively examine the 3D evolution of CEE from the moment when the mass loss commences to the remnant phase. I expect to resolve the long timescales observed in RT, characterize binary stability in 3D with detailed microphysics, illuminate the fundamental problem of how is orbital energy used to unbind the common envelope in a regime that was inaccessible before, and break new ground on the amplification of magnetic fields during CEE.I will establish RT as an entirely new probe of the CEE physics by comparing my detailed theoretical predictions of light curves from different viewing angles, spectra, line profiles, and polarimetric signatures with observations of RT.  I will accomplish this  by coupling multi-dimensional moving mesh hydrodynamics with radiation, dust formation, and chemical reactions. Finally, I will examine the physical processes in RT remnants on timescales of years to centuri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-Dimensional Resource Management for 6G IoT Networks with Generative Artificial Intelligence' under Horizon Europe.

assistant: **Concept**

The Internet of Things (IoT) has fundamentally changed our interaction with the physical world, bringing a paradigm shift that has transitioned physical objects into digital and interconnected devices. This digitalization revolution largely hinges on to take a significant leap forward with the deployment of emerging 6G networks. While 6G holds great promise, it also poses severe challenges, especially in dynamically managing its vast multi-dimension resources amid heightened demands for latency, rates, reliability etc. Traditional approaches, particularly those relying on Deep Reinforcement Learning (DRL), have obvious limitations in various and complex 6G IoT networks. In this context, we will explore Generative Artificial Intelligence (GAI) to solve these challenges. First, we will establish a hypergraph-based framework for multi-dimensional resource representation and modeling, targeting the optimization of service capabilities. Subsequently, we will use the Generative Diffusion Model (GDM) to streamline communication intent extraction, facilitating swift decision-making and improving the adaptability of the network. Finally, we will leverage GDM in crafting resilient incentive structures, aiming to ensure the fairness of resource distribution and enhance user experience in the 6G IoT environment. The project has three work packages (WPs): WP1 aims at designing measurements for multi-dimensional resources, WP2 investigates the utilization of GDM for adaptive resource management, and in WP3, we seek to use GDM to ensure fairness in resource sharing. By integrating GAI as a solution to the multifaceted challenges of 6G IoT, we seek to expand and redefine the capabilities and applications of 6G IoT in real-world contexts.


**Keywords:** 6G IoT, Multi-dimensional Resour