RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Warsaw Quantum-Nano-Bio-Technology Pole Fellowship Program' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The proposal aims to set up a pole of excellence in the three topics of Quantum Technology, Nanotechnology, and Biotechnology at the three closely collaborating Polish Academy of Sciences institutions of the Institute of Physics, the Center For Theoretical Physics, and the Institute of High Pressure Physics in Warsaw, Poland. The pole of excellence will be based on fully impartial recruitment of 16 top quality postdoctoral fellows for 3 year durations, using an innovative and flexible recruitment formula. They will be provided with excellent mentors on-site, top tier mentor-collaborators in overseas institutions and industrial partners to be visited during secondments, as well as top quality innovative career training during their fellowships. A mechanism for retention of well performing and willing participants into tenure-track positions in the host institutions after the fellowship will be provided. The recruitment will be made and other key decisions overseen by an International Steering Committee. The project will be co-financed by funding from the Polish Ministry of Science and Higher Education.


**Keywords:** Quantum Technology, Nanotechnology, Biotechnology, Physics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Amygdala CRF in reduced anxiety and alcohol consumption in PKCepsilon null mice'.

assistant: **Concept**

Alcoholism, a major health issue worldwide, is characterized by high rates of relapse. Stress/anxiety probably contribute to relapse vulnerability and are the topic of this proposal.To determine the role in addiction of novel genes such as PKCe, which is regulated by alcohol, behavioural analysis of knockout mice is required. During her PhD project, H.Lesscher studied cocaine reinforcement in µ-opioid receptor mutant mice. With this, she was the first in the Rudolf Magnus Institute of Neuroscience to set up addiction-related research in mice. However, she and the laboratory would benefit from refinement of the behavioural paradigms, which is the rationale behind this application.The host institute, Dr. Messing's laboratory at the Ernest Gallo Clinic and Research Centre, is well experienced with mouse behaviour, particularly anxiety and alcoholism.This proposal will investigate amygdala CRF regulation in the context of alcohol withdrawal-induced anxiety and alcohol consumption in PKCe null mice. Recent studies in Dr. Messing's laboratory have shown that PKCe null mice are less anxious, consume less alcohol and display a reduced 'alcohol deprivation effect' as compared to wild-type mice.Further, amygdala CRF, GABAA activity and plasma corticosterone deviate from wild-type. This proposal will therefore investigate, in PKCe null mice, the relation between alcohol withdrawal-induced anxiety and alcohol consumption and the underlying mechanisms.Upon returning to the Netherlands, H. Lesscher will implement t he skills and experience gained to investigate opioid gene x environment interactions in drug reinforcement, thereby improving the competitiveness of European addiction researchers.This international training at the Gallo Centre will further increase the probability of H.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Rapid, portable and reliable cargo screener - New concept of vapour screening technology - Ion Mobility Chemical Fingerprint Detector' (METEOR), addressing dissemination and exploitation.

assistant: **Impact**

Safe and legal global transport is essential to human welfare, but it demands that customs authorities implement security regulations with a special focus on illicit goods. To enable enforcement of regulations tackling illicit goods trafficking, customs authorities have expressed their need for portable, affordable, non-intrusive, reliable screening technologies aiming to facilitate on-site and rapid inspections. The current technologies are mainly based on X-ray screening, but have its limitations in detecting illicit goods, are very expensive and the process is time consuming. This makes that currently less than 5% of the containers may be inspected, which is undesirable for customs authorities and society. In the METEOR project, the consortium will develop a prototype of a portable and versatile air sampling-based screening system. This will enable customs administrations worldwide to rapidly and reliably inspect for the presence of illicit goods. The METEOR technology will provide a new concept of cargo screening detector with a highly efficient air sampling technique and the ion mobility multidetector sensing technology. The METEOR analyser relies on a very innovative concept of a multi-detector differential mobility analyser (DMA), that classifies molecular ions based upon their electrical mobility. This generates a chemical fingerprint of the samples, and after the processing with non-targeted screening techniques, it is possible to accurately classify and detect the threats. The focus will be on the detection of illicit drugs, but also explosives and other substances. The goal is to develop the METEOR technology up to TRL7, and validate it in the operational environment. This is done by the four customs administrations (The Netherlands, Belgium, Spain and Irelan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Neuroscience serving regional integration, higher education and welfare of the society', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Supplementing our research strategy with relevant fields of genetics and molecular biology- Gaining more expertise in applied genetics and molecular neurobiology via international networking- Offering our expertise in neuroscience and neuro endocrinology for other centres- Integrating neuroscience with clinical and pharmaceutical research- Disseminating information about the achievements of neurobiology to the society- Improving the socio-economic environment via qualified research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Accelerated Early staGe drug diScovery' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, European innovation in new drug registrations is dramatically falling behind compared to the US and Asia.The principal aim of the AEGIS ITN is to implement the first comprehensive, intersectoral cross-disciplinary and structured curriculum for doctoral students in the European Research Area by establishing a unique training platform for the next generation of European researchers in early drug discovery. A significant added value is provided through networking with key European pharmaceutical companies. A key research aim of AEGIS is improving the efficiency and success of early stage drug development by combining innovative methods and techniques to tackle difficult but promising targets (i.e. protein-protein interactions), as potentially valuable drug targets are often neglected due to the high risk associated with their validation.The consortium joins leading academic and industry researchers in an open innovation environment for innovative drug development in Europe. It is supported by several additional partners and stakeholders in the field. Integrated training of the fellows takes place at the host institute and by secondments, research schools and individual training within the AEGIS network. The scientific training includes complementary skills, management, intellectual property rights, fund raising, communication and career planning. AEGIS will improve the availability of a highly skilled workforce for European industries and research, greatly enhance the employability and the career perspectives of young researchers for academia as well as for industry, and will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Blood as energy source to power smart cardiac devices' under Horizon Europe.

assistant: **Concept**

Cardiovascular diseases (CVD) are the leading cause of death globally, taking 18.6M lives/yr. Most CVD are associated with blockage ofblood vessels.   grafts play a vital role, replacing/bypassing these vessels, but have failure rates up to 50% due to thrombosis or infection. Vascular grafts of the future would ideally sense and monitor its performance, and telemetrically emit data/alerts to healthcare system so that medical actions can be performed to avoid graft failure. IoMTs has taken its first steps, but is still far from full potential/development, especially in implantable systems which are limited by the use of batteries to power them.The BLOOD2POWER project AIMS to contribute to this paradigm shift by proposing the development of a NEW WAY TO HARVEST ENERGY FROM THE BODY, and using it to create the next generation vascular grafts: the iGraft.To achieve this PIONEER technology, new triboelectric nanogenerators (TENG) will be developed, converting mechanical energy from the body into electrical energy. A miniaturized ultra-low energy consumption power management unit will be developed and coupled to the vascular graft together with a wireless system, allowing to store generated energy, and collect and wirelessly transmit TENG outputs to an external electronic device (e.g. smartphone/watch). These systems will be validated in vitro and in vivo.Driven by these challenges, this international team led by a young researcher gathers renown institutions and researchers with unique and complementary backgrounds in biomaterials, energy harvesting, electronics and medicine.


**Keywords:** Energy harvesting; Triboelectric nanogenerators; Blood; Cardiovascular electronic devices; Vascular Grafts; Biocompatible materials; Internet of Medical Things; Low-Power consumption ele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Trusted Architecture for Securely  Shared  Services' in the context of a Seventh Framework call.

assistant: **Objectives**

The TAS3 (Trusted Architecture for Securely Shared Services) proposes an Integrated Project that will develop and implement an architecture with trusted services to manage and process distributed personal information. <br/>This architecture will be dependable, robust but at the same time also cost-effective and reliable. The personal information that will be processed and managed can consist of any type of information that is owned by or refers to people. <br/>The proposed architecture therefore has to be generic and cross-domain applicable. TAS3 will focus an instantiation of this architecture in the employability and e-health sector allowing users and service providers in these two sectors to manage the lifelong generated personal employability and e-health information of the individuals involved. <br/>The personal information includes in this case to the interests, current and previous activities, and future objectives, where the service providers will then be able to use these preferences to propose career paths that are compatible with the worker's objectives. This process-view on lifelong employability of people perfectly fits in the decision number 1672/2006/EC of the European Parliament and of the Council of 24 October 2006 establishing a Community Programme for Employment and Social Solidarity <br/>The healthcare sector is another context in which the TAS3 architecture can be instantiated. In this case, the patient could be offered advanced services based on the health parameters (weight, body temperature, glucose level for diabetes patients, etc.) that are input by the patient himself. Processing the medical record of a patient is not included in the scope of this project because this would introduce too many privacy and data protection issues that are typical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Asian Revolutions in European Public Discourse 1644-1800' (2002-2006).

assistant: **Innovation**

The project focuses on early modern European concepts and perceptions of Asia. In the seventeenth and eighteenth centuries the political landscape of Asia changed dramatically. From the Ottoman Empire to Persia, from North India and Southeast Asia to China and Japan, Asian monarchies underwent processes of dynastic decline, experiencing radical and pervasive changes in society and culture. These events attracted the attention of a wide array of European commentators.The central question of this project is why Europeans devoted such care and attention to Asian political events and upheavals, the ideological purposes and orientations of their reports and discussions, and the narrative of revolution as implied allegory. During this period, the imagination of the reading public and more especially of historians was captivated by political events in China, Persia, Southeast Asia and India. Beforehand, these countries had often existed in a nebulous realm of fantasy. Narratives of political revolution transformed t hem into dynamic societies experiencing rapid change. What is more, the timeless 'despotism' later associated with the East in nineteenth-century European political thought was contradicted by coups and uprisings which had a fascination in their own right but which were also read implicitly as allegory by a European audience.The project focuses on three important cases in the seventeenth and eighteenth centuries: the Manchurian conquest of China (1644); the exchange of diplomatic missions between Siam and France and the execution of Siam's minister of trade, Constantine Phaulcon (a Greek national) after the death of King Narai (1680-88); and the rise and fall of Nadir Shah in Persia (r. 1736-47).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular-genetic approaches to study the role of FT in photoperiodic flowering of Arabidopsis' in the context of a Seventh Framework call.

assistant: **Objectives**

Proteins related to FLOWERING LOCUS T (FT) strongly induce flowering of many plant species. In Arabidopsis thaliana FT is a component of the photoperiodic pathway and its transcription is activated under long days characteristic of summer. Recent studies showed that FT protein is expressed in the leaf vascular tissue and then moves through the phloem to the shoot apex, where it causes changes in gene expression that reprogram the shoot apical meristem to form flowers instead of leaves. Although transgenic experiments suggest FT protein is sufficient to induce flowering, it may nevertheless act together with other mobile components and genes induced by FT in the leaf might facilitate FT movement or function. In addition, molecular analysis of the pathways that regulate flowering-time in response to environmental signals suggests that many components of these pathways remain to be identified. This project proposes the use of molecular genetics and genomics approaches to reach three major objectives: (1) to identify genes involved in FT function or transport (2) to study the effect of the identified genes on flowering time and position them within the flowering pathway network (3) to study the effect of identified genes on FT transport by confocal microscopy. Preliminary results support the feasibility of the proposal, such as the identification of interesting genes whose expression is affected by FT in leaves and isolation of early-flowering mutants in genetic backgrounds null for FT activity. Training will take place at the MPI for Plant Breeding, Cologne and will complement the researcher`s existing skills in molecular biology by adding expertise in bioinformatic approaches, next generation sequencing and confocal microscopy. The technical expertise gained, the material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Global antibiotic resistance by bacteria is becoming an incrasing public health concern, and the race is on to dicover new antibacterials (bax et al., 2000).' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The Background The Problem: Global antibiotic resistance by bacteria is becoming an increasing public health concern, and the race is on to discover new antibacterial (Bax et al., 2000). The importance of carrying out this type of research and surveillance of antibiotic resistance is critical (reviewed by Aubry-Damon and Courvalin, 1999). In addition to the use of antibiotics, non-steroidal anti- inflammatory drugs (NSAIDs) are also used routinely to treat numerous gram-negative infections. However, there are increasing concerns over complications caused by NSAIDS in infections an in this field, nez therapeutics are also in demand. Therefore, the aim of this investigation was to;- Determination and comparison of the anti-microbial actins of Aloe vera Barbadensis Miller with ampicilllin and nalidixic acid (routine antibiotics for the treatment of shigellosis). This was achieved by investigating the minimum inhibitory concentrations of Aloe Vera needed to kill Shigella Flexneri.- Determination and comparison of the anti-inflammatory actions of Aloe vera Barbadensis Miller with a known NSAID (Ibuprofen).This was achieved by investigating TNF-alfa and IL-1Beta release by blood cells incubated with Shigella flexneri. These results were similar to those obtained by Shelton (1991) who showed that Aloe Vera had anti-microbial properties in vitro and inhibited Mycobacterium tuberculosis and Bacillus subtilis. S.flexneri has been shown to be completely resistant to ampicillin at concentrations greater than 256 µg/ml (Navia et al., 1999). It is thought that antibiotic resistance in shigellosis is due to the over use of antibiotics (Travis, 1994). As with many antibiotics, nalidixic acid has many side-effects when given at this dose, including nausea, vomiting, dyspepsia, abdominal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring the nucleation of large earthquakes: cascading and unpredictable or slowly driven and forecastable' under Horizon 2020.

assistant: **Concept**

How do earthquakes begin? Answering this question is essential to understand fault mechanics but also todetermine our ability to forecast large earthquakes. Although it is well established that some events are preceded by foreshocks, contrasting views have been proposed on the nucleation of earthquakes. Do these foreshocks belong to a cascade of random failures leading to the mainshock? Are they triggered by an aseismic nucleation phase in which the fault slips slowly before accelerating to a dynamic, catastrophic rupture? Will we ever be able to monitor and predict the slow onset of earthquakes or are we doomed to observe random, unpredictable cascades of events? We are currently missing a robust tool for quantitative estimation of the proportion of seismic versus aseismic slip during the rupture initiation, cluttering our attempts at understanding what physical mechanisms control the relationship between foreshocks and the onset of large earthquakes.The current explosion of available near-fault ground-motion observations is an unprecedented opportunity to capture the genesis of earthquakes along active faults. I will develop an entirely new method based a novel data assimilation procedure that will produce probabilistic time-dependent slip models assimilating geodetic, seismic and tsunami datasets. While slow and rapid fault processes are usually studied independently, this unified approach will address the relative contribution of seismic and aseismic deformation.The first step is the development of a novel probabilistic data assimilation method providing reliable uncertainty estimates and combining multiple data types. The second step is a validation of the method and an application to investigate the onset of recent megathrust earthquakes in Chile and Japan. The th